format-version: 1.2
data-version: releases/2024-11-29
subsetdef: chebi_ph7_3 "Rhea list of ChEBI terms representing the major species at pH 7.3."
subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation"
subsetdef: gocheck_obsoletion_candidate "Terms planned for obsoletion"
subsetdef: goslim_agr "AGR slim"
subsetdef: goslim_aspergillus "Aspergillus GO slim"
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_chembl "ChEMBL protein targets summary"
subsetdef: goslim_drosophila "Drosophila GO slim"
subsetdef: goslim_euk_cellular_processes_ribbon "GO ribbon for eukaroytic cellular processes"
subsetdef: goslim_flybase_ribbon "Insecta GO ribbon slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_metagenomics "Metagenomics GO slim"
subsetdef: goslim_mouse "Mouse GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_plant_ribbon "Plant GO ribbon"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_prokaryote "GO subset for prokaryotes"
subsetdef: goslim_prokaryote_ribbon "Prokaryote GO ribbon slim"
subsetdef: goslim_synapse "synapse GO slim"
subsetdef: goslim_virus "GO subset for viruses"
subsetdef: goslim_yeast "Yeast GO slim"
synonymtypedef: syngo_official_label "label approved by the SynGO project"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: gene_ontology
ontology: go

[Term]
id: GO:0000001
name: mitochondrion inheritance
namespace: biological_process
def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764]
synonym: "mitochondrial inheritance" EXACT []
is_a: GO:0048308 ! organelle inheritance
is_a: GO:0048311 ! mitochondrion distribution

[Term]
id: GO:0000002
name: mitochondrial genome maintenance
namespace: biological_process
def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0000003
name: obsolete reproduction
namespace: biological_process
alt_id: GO:0019952
alt_id: GO:0050876
def: "OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is that this term is equivalent to reproductive process.
synonym: "reproductive physiological process" EXACT []
is_obsolete: true
replaced_by: GO:0022414

[Term]
id: GO:0000005
name: obsolete ribosomal chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913]
comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function.
synonym: "ribosomal chaperone activity" EXACT []
is_obsolete: true
consider: GO:0042254
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0000006
name: high-affinity zinc transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1]
synonym: "high affinity zinc uptake transmembrane transporter activity" EXACT []
synonym: "high-affinity zinc uptake transmembrane transporter activity" RELATED []
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000007
name: low-affinity zinc ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000008
name: obsolete thioredoxin
namespace: molecular_function
alt_id: GO:0000013
def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd]
comment: This term was made obsolete because it represents gene products.
synonym: "thioredoxin" EXACT []
is_obsolete: true
consider: GO:0003756
consider: GO:0015036

[Term]
id: GO:0000009
name: alpha-1,6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248]
synonym: "1,6-alpha-mannosyltransferase activity" EXACT []
xref: Reactome:R-HSA-449718 "Addition of a third mannose to the N-glycan precursor by ALG2"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000010
name: heptaprenyl diphosphate synthase activity
namespace: molecular_function
alt_id: GO:0036422
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate." [PMID:9708911, RHEA:27794]
synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "HepPP synthase activity" RELATED [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthase activity" RELATED [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.30]
synonym: "trans-hexaprenyltranstransferase activity" EXACT []
xref: EC:2.5.1.30
xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN
xref: RHEA:27794
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0000011
name: vacuole inheritance
namespace: biological_process
def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0000012
name: single strand break repair
namespace: biological_process
def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [PMID:18626472]
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0000014
name: single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah]
synonym: "single-stranded DNA specific endodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific endodeoxyribonuclease activity" RELATED [GOC:mah]
is_a: GO:0004520 ! DNA endonuclease activity

[Term]
id: GO:0000015
name: phosphopyruvate hydratase complex
namespace: cellular_component
def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]
subset: goslim_metagenomics
synonym: "enolase complex" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0000016
name: lactase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [PMID:12023280]
synonym: "lactose galactohydrolase activity" EXACT []
xref: EC:3.2.1.108
xref: MetaCyc:BETAGALACTOSID-RXN
xref: Reactome:R-HSA-189062 "lactose + H2O => D-glucose + D-galactose"
xref: Reactome:R-HSA-5658001 "Defective LCT does not hydrolyze Lac"
xref: RHEA:10076
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0000017
name: alpha-glucoside transport
namespace: biological_process
def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, ISBN:0198506732, PMID:9919658]
is_a: GO:0042946 ! glucoside transport

[Term]
id: GO:0000018
name: regulation of DNA recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0000019
name: regulation of mitotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]
synonym: "regulation of recombination within rDNA repeats" NARROW []
is_a: GO:0000018 ! regulation of DNA recombination
relationship: regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0000020
name: obsolete negative regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it describes a substrate-specific process.
synonym: "negative regulation of recombination within rDNA repeats" EXACT []
is_obsolete: true
consider: GO:0045950

[Term]
id: GO:0000022
name: mitotic spindle elongation
namespace: biological_process
alt_id: GO:1905121
def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B." [GOC:mtg_cell_cycle, GOC:vw, PMID:19686686]
synonym: "microtubule sliding involved in mitotic spindle elongation" RELATED []
synonym: "spindle elongation during mitosis" EXACT []
is_a: GO:0051231 ! spindle elongation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0000023
name: maltose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732]
synonym: "malt sugar metabolic process" EXACT []
synonym: "malt sugar metabolism" EXACT []
synonym: "maltose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0000024
name: maltose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732]
synonym: "malt sugar biosynthesis" EXACT []
synonym: "malt sugar biosynthetic process" EXACT []
synonym: "maltose anabolism" EXACT []
synonym: "maltose biosynthesis" EXACT []
synonym: "maltose formation" EXACT []
synonym: "maltose synthesis" EXACT []
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0000025
name: maltose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732]
synonym: "malt sugar catabolic process" EXACT []
synonym: "malt sugar catabolism" EXACT []
synonym: "maltose breakdown" EXACT []
synonym: "maltose degradation" EXACT []
synonym: "maltose hydrolysis" NARROW []
xref: MetaCyc:MALTOSECAT-PWY
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0000026
name: alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541]
xref: Reactome:R-HSA-446187 "ALG11 transfers the fourth and fifth Man to the N-glycan precursor"
xref: Reactome:R-HSA-446215 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1"
xref: Reactome:R-HSA-446216 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1"
xref: Reactome:R-HSA-4551297 "Defective ALG11 does not transfer Man to the N-glycan precursor"
xref: Reactome:R-HSA-4720478 "Defective ALG9 does not add the seventh mannose to the N-glycan precursor"
xref: Reactome:R-HSA-9035514 "Defective ALG9 does not add the last mannose to the N-glycan precursor"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000027
name: ribosomal large subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]
synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah]
synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah]
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0042255 ! ribosome assembly
relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis

[Term]
id: GO:0000028
name: ribosomal small subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428]
synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah]
synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah]
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0042255 ! ribosome assembly
relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis

[Term]
id: GO:0000030
name: mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]
xref: Reactome:R-HSA-162797 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI"
xref: Reactome:R-HSA-162830 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate"
xref: Reactome:R-HSA-446198 "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1"
xref: Reactome:R-HSA-4720497 "Defective ALG12 does not add mannose to the N-glycan precursor"
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0000031
name: mannosylphosphate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + n {[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]-alpha-D-Man-(1->6)}60-(Man9GlcNAc2-[protein] = phosphorylated {[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]-alpha-D-Man-(1->6)}60-(Man9GlcNAc2-[protein] + n GMP + n H+ or GDP-alpha-D-mannose + alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] = alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-[alpha-D-Man-6P-]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-3-O-(Ser/Thr)-[protein] + GMP + H+." [MetaCyc:RXN-22693, MetaCyc:RXN-22694]
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0000032
name: cell wall mannoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai]
synonym: "cell wall mannoprotein anabolism" EXACT []
synonym: "cell wall mannoprotein biosynthesis" EXACT []
synonym: "cell wall mannoprotein formation" EXACT []
synonym: "cell wall mannoprotein synthesis" EXACT []
is_a: GO:0006057 ! mannoprotein biosynthetic process
is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process

[Term]
id: GO:0000033
name: alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:mcc, PMID:10521541]
xref: Reactome:R-HSA-446188 "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1"
xref: Reactome:R-HSA-446208 "Addition of a second mannose to the N-glycan precursor by ALG2"
xref: Reactome:R-HSA-4549368 "Defective ALG2 does not transfer a second Man to N-glycan precursor"
xref: Reactome:R-HSA-4720473 "Defective ALG3 does not add mannose to the N-glycan precursor"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000034
name: adenine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenine + H+ + H2O = hypoxanthine + NH4+." [RHEA:23688]
synonym: "ADase activity" RELATED [EC:3.5.4.2]
synonym: "adenase activity" RELATED [EC:3.5.4.2]
synonym: "adenine aminase activity" RELATED [EC:3.5.4.2]
synonym: "adenine aminohydrolase activity" RELATED [EC:3.5.4.2]
xref: EC:3.5.4.2
xref: MetaCyc:ADENINE-DEAMINASE-RXN
xref: RHEA:23688
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0000035
name: acyl binding
namespace: molecular_function
def: "Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732]
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0000036
name: acyl carrier activity
namespace: molecular_function
def: "Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis." [GOC:jl, GOC:vw]
synonym: "ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process" EXACT []
is_a: GO:0044620 ! ACP phosphopantetheine attachment site binding
is_a: GO:0140414 ! phosphopantetheine-dependent carrier activity

[Term]
id: GO:0000038
name: very long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:hjd]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very long chain fatty acid metabolic process" EXACT [GOC:bf]
synonym: "very-long-chain fatty acid metabolic process" EXACT []
synonym: "very-long-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0000039
name: obsolete plasma membrane long-chain fatty acid transporter
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and it contains component information.
synonym: "plasma membrane long-chain fatty acid transporter" EXACT []
is_obsolete: true
consider: GO:0005324
consider: GO:0005886

[Term]
id: GO:0000041
name: transition metal ion transport
namespace: biological_process
def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
synonym: "transition metal transport" EXACT []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0000044
name: obsolete ascorbate stabilization
namespace: biological_process
def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport]
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
synonym: "ascorbate stabilization" EXACT []
synonym: "vitamin C stabilization" EXACT []
is_obsolete: true

[Term]
id: GO:0000045
name: autophagosome assembly
namespace: biological_process
def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]
synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "autophagic vacuole formation" RELATED [GOC:mah]
synonym: "autophagosome biosynthesis" EXACT []
synonym: "autophagosome formation" EXACT []
synonym: "PAS formation" NARROW []
is_a: GO:0070925 ! organelle assembly
is_a: GO:1905037 ! autophagosome organization

[Term]
id: GO:0000047
name: obsolete Rieske iron-sulfur protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "Rieske iron-sulfur protein" EXACT []
synonym: "Rieske iron-sulphur protein" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0000048
name: peptidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme." [PMID:11433365, PMID:9242921]
xref: EC:2.3.2.12
xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN
xref: Reactome:R-HSA-156912 "Peptide transfer from P-site tRNA to the A-site tRNA"
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0000049
name: tRNA binding
namespace: molecular_function
alt_id: GO:0000946
def: "Binding to a transfer RNA." [GOC:ai]
synonym: "base pairing with tRNA" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000050
name: urea cycle
namespace: biological_process
alt_id: GO:0006594
alt_id: GO:0006871
def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732]
synonym: "ornithine cycle" EXACT []
synonym: "urea biosynthesis" EXACT []
synonym: "urea biosynthetic process" EXACT []
xref: Wikipedia:Urea_cycle
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0000051
name: obsolete urea cycle intermediate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
synonym: "urea cycle intermediate metabolic process" EXACT []
synonym: "urea cycle intermediate metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0000052
name: citrulline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]
synonym: "citrulline metabolism" EXACT []
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0000053
name: argininosuccinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732]
synonym: "argininosuccinate metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0000054
name: ribosomal subunit export from nucleus
namespace: biological_process
def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai]
subset: goslim_yeast
synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah]
synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0033750 ! ribosome localization
is_a: GO:0051168 ! nuclear export
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0000055
name: ribosomal large subunit export from nucleus
namespace: biological_process
alt_id: GO:0000057
def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "ribosomal large subunit export from cell nucleus" EXACT []
synonym: "ribosomal large subunit export out of nucleus" EXACT []
synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal large subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000056
name: ribosomal small subunit export from nucleus
namespace: biological_process
alt_id: GO:0000058
def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "ribosomal small subunit export from cell nucleus" EXACT []
synonym: "ribosomal small subunit export out of nucleus" EXACT []
synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal small subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000059
name: obsolete protein import into nucleus, docking
namespace: biological_process
def: "OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736]
comment: This term was made obsolete because the transient assembly is better captured as a protein-protein association, if at all.
synonym: "protein docking during protein import into nucleus" EXACT []
synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein docking during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, docking" EXACT []
synonym: "protein-nucleus import, docking" EXACT []
is_obsolete: true

[Term]
id: GO:0000060
name: obsolete protein import into nucleus, translocation
namespace: biological_process
def: "OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736]
comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used.
synonym: "protein import into cell nucleus, translocation" EXACT []
synonym: "protein translocation during protein import into nucleus" EXACT []
synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein translocation during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT []
synonym: "protein-nucleus import, translocation" EXACT []
is_obsolete: true

[Term]
id: GO:0000061
name: obsolete protein import into nucleus, substrate release
namespace: biological_process
def: "OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515]
comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used.
synonym: "protein import into cell nucleus, substrate release" EXACT []
synonym: "protein substrate release during protein import into nucleus" EXACT []
synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein substrate release during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT []
synonym: "protein-nucleus import, substrate release" EXACT []
is_obsolete: true

[Term]
id: GO:0000062
name: fatty-acyl-CoA binding
namespace: molecular_function
def: "Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]
synonym: "fatty-acyl binding" BROAD []
synonym: "fatty-acyl-coenzyme A binding" EXACT []
xref: Reactome:R-HSA-8848247 "ACBD4,5 bind MCFA-CoA and LCFA-CoA"
is_a: GO:0120227 ! acyl-CoA binding
is_a: GO:1901567 ! fatty acid derivative binding

[Term]
id: GO:0000064
name: L-ornithine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED []
synonym: "L-ornithine transporter activity" BROAD []
xref: Reactome:R-HSA-70634 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0000067
name: obsolete DNA replication and chromosome cycle
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
synonym: "DNA replication and chromosome cycle" EXACT []
is_obsolete: true
consider: GO:0006260
consider: GO:0007059
consider: GO:0051276

[Term]
id: GO:0000070
name: mitotic sister chromatid segregation
namespace: biological_process
alt_id: GO:0016359
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
subset: goslim_pombe
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0000072
name: obsolete M phase specific microtubule process
namespace: biological_process
def: "OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah]
comment: This term was made obsolete because terms already exist for centrosome/spindle organization which would be more suitable for the existing annotations, and the phase could be captured as an annotation extension if necessary.
synonym: "M phase specific microtubule process" EXACT []
synonym: "M-phase specific microtubule process" EXACT []
is_obsolete: true
consider: GO:0007017

[Term]
id: GO:0000073
name: initial mitotic spindle pole body separation
namespace: biological_process
alt_id: GO:0030475
def: "The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB." [GOC:sgd_curators, GOC:vw]
is_a: GO:0110100 ! spindle pole body separation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0061804 ! mitotic spindle formation (spindle phase one)
relationship: part_of GO:1905047 ! mitotic spindle pole body organization

[Term]
id: GO:0000075
name: cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0031576
alt_id: GO:0071779
alt_id: GO:0072395
alt_id: GO:0072404
alt_id: GO:0072407
def: "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle]
comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.
subset: gocheck_do_not_annotate
synonym: "cell cycle checkpoint" EXACT []
synonym: "G1/S checkpoint" NARROW []
synonym: "G1/S transition checkpoint" NARROW []
synonym: "G2/M checkpoint" NARROW []
synonym: "G2/M transition checkpoint" NARROW []
synonym: "signal transduction involved in cell cycle checkpoint" EXACT []
synonym: "signal transduction involved in G2/M transition checkpoint" EXACT []
xref: Wikipedia:Cell_cycle_checkpoint
is_a: GO:0035556 ! intracellular signal transduction
is_a: GO:1901988 ! negative regulation of cell cycle phase transition

[Term]
id: GO:0000076
name: DNA replication checkpoint signaling
namespace: biological_process
alt_id: GO:0072437
def: "A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]
synonym: "DNA replication checkpoint" EXACT []
synonym: "signal transduction involved in DNA replication checkpoint" EXACT []
is_a: GO:0031570 ! DNA integrity checkpoint signaling

[Term]
id: GO:0000077
name: DNA damage checkpoint signaling
namespace: biological_process
alt_id: GO:0072422
def: "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]
synonym: "DNA damage checkpoint" EXACT []
synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW []
synonym: "signal transduction involved in DNA damage checkpoint" EXACT []
xref: Wikipedia:DNA_damage_checkpoint
xref: Wikipedia:Postreplication_checkpoint
is_a: GO:0031570 ! DNA integrity checkpoint signaling
is_a: GO:0042770 ! signal transduction in response to DNA damage

[Term]
id: GO:0000078
name: obsolete cytokinesis after mitosis checkpoint
namespace: biological_process
def: "OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis." [GOC:mtg_cell_cycle]
comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning.
synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw]
synonym: "cell shape checkpoint" EXACT []
is_obsolete: true
consider: GO:0044878
consider: GO:0044879

[Term]
id: GO:0000079
name: regulation of cyclin-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
subset: gocheck_obsoletion_candidate
synonym: "regulation of CDK activity" EXACT []
synonym: "regulation of cyclin-dependent protein kinase activity" BROAD []
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0000080
name: mitotic G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G1 phase of mitotic cell cycle" EXACT []
is_a: GO:0051318 ! G1 phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000082
name: G1/S transition of mitotic cell cycle
namespace: biological_process
def: "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]
is_a: GO:0044772 ! mitotic cell cycle phase transition
is_a: GO:0044843 ! cell cycle G1/S phase transition

[Term]
id: GO:0000083
name: obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000082
consider: GO:0006357

[Term]
id: GO:0000084
name: mitotic S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "S phase of mitotic cell cycle" EXACT []
synonym: "S-phase of mitotic cell cycle" EXACT []
is_a: GO:0051320 ! S phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000085
name: mitotic G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G2 phase of mitotic cell cycle" EXACT []
is_a: GO:0051319 ! G2 phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000086
name: G2/M transition of mitotic cell cycle
namespace: biological_process
def: "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]
synonym: "mitotic G2/M transition" EXACT []
is_a: GO:0044772 ! mitotic cell cycle phase transition
is_a: GO:0044839 ! cell cycle G2/M phase transition

[Term]
id: GO:0000087
name: mitotic M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M phase of mitotic cell cycle" EXACT []
synonym: "M-phase of mitotic cell cycle" EXACT []
is_a: GO:0000279 ! M phase
is_a: GO:0098763 ! mitotic cell cycle phase

[Term]
id: GO:0000088
name: mitotic prophase
namespace: biological_process
def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000089
name: mitotic metaphase
namespace: biological_process
def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051323 ! metaphase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000090
name: mitotic anaphase
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051322 ! anaphase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000091
name: mitotic anaphase A
namespace: biological_process
def: "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000092
name: mitotic anaphase B
namespace: biological_process
def: "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000093
name: mitotic telophase
namespace: biological_process
def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000094
name: obsolete septin assembly and septum formation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was not defined and the string name implied two separate processes.
synonym: "septin assembly and septum formation" EXACT []
is_obsolete: true
consider: GO:0000917
consider: GO:0000918
consider: GO:0000921

[Term]
id: GO:0000095
name: S-adenosyl-L-methionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015177
def: "Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]
synonym: "S-adenosyl methionine permease activity" EXACT []
synonym: "S-adenosyl methionine transporter activity" EXACT []
synonym: "S-adenosylmethionine permease activity" EXACT []
synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT []
synonym: "S-adenosylmethionine transporter activity" BROAD []
synonym: "SAM transmembrane transporter activity" EXACT []
xref: Reactome:R-HSA-8855062 "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0000096
name: sulfur amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]
synonym: "sulfur amino acid metabolism" EXACT []
synonym: "sulphur amino acid metabolic process" EXACT []
synonym: "sulphur amino acid metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0000097
name: sulfur amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
synonym: "sulfur amino acid anabolism" EXACT []
synonym: "sulfur amino acid biosynthesis" EXACT []
synonym: "sulfur amino acid formation" EXACT []
synonym: "sulfur amino acid synthesis" EXACT []
synonym: "sulphur amino acid biosynthesis" EXACT []
synonym: "sulphur amino acid biosynthetic process" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0000098
name: sulfur amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
synonym: "sulfur amino acid breakdown" EXACT []
synonym: "sulfur amino acid catabolism" EXACT []
synonym: "sulfur amino acid degradation" EXACT []
synonym: "sulphur amino acid catabolic process" EXACT []
synonym: "sulphur amino acid catabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0000099
name: sulfur amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "sulfur amino acid transporter activity" BROAD []
synonym: "sulphur amino acid transmembrane transporter activity" EXACT []
synonym: "sulphur amino acid transporter activity" BROAD []
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0000100
name: S-methylmethionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015178
def: "Enables the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai]
synonym: "S-methylmethionine permease activity" EXACT []
synonym: "S-methylmethionine transporter activity" BROAD []
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0000101
name: sulfur amino acid transport
namespace: biological_process
def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "sulphur amino acid transport" EXACT []
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0000102
name: L-methionine secondary active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
synonym: "L-methionine porter activity" RELATED []
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015191 ! L-methionine transmembrane transporter activity

[Term]
id: GO:0000103
name: sulfate assimilation
namespace: biological_process
alt_id: GO:0019378
def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]
synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW []
synonym: "sulphate assimilation" EXACT []
synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW []
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0000104
name: succinate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0019739
def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [RHEA:16357]
synonym: "fumarate dehydrogenase activity" EXACT []
synonym: "fumarate reductase activity" EXACT []
synonym: "fumaric hydrogenase activity" RELATED []
synonym: "succinate oxidoreductase activity" EXACT []
synonym: "succinic acid dehydrogenase activity" EXACT []
synonym: "succinic dehydrogenase activity" BROAD []
synonym: "succinodehydrogenase activity" EXACT []
synonym: "succinyl dehydrogenase activity" EXACT []
xref: KEGG_REACTION:R00412
xref: RHEA:16357
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0000105
name: L-histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
synonym: "histidine anabolism" EXACT []
synonym: "histidine biosynthesis" EXACT []
synonym: "histidine biosynthetic process" BROAD []
synonym: "histidine formation" EXACT []
synonym: "histidine synthesis" EXACT []
xref: MetaCyc:HISTSYN-PWY
is_a: GO:0006547 ! L-histidine metabolic process
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process

[Term]
id: GO:0000107
name: imidazoleglycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+." [RHEA:24793]
synonym: "glutamine amidotransferase:cyclase activity" BROAD []
synonym: "imidazole glycerol phosphate synthase activity" EXACT []
synonym: "imidazole-glycerol-phosphate synthase activity" RELATED []
synonym: "imidazoleglycerol phosphate synthase activity" EXACT []
xref: MetaCyc:GLUTAMIDOTRANS-RXN
xref: RHEA:24793
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0000108
name: obsolete repairosome
namespace: cellular_component
def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079]
comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators.
synonym: "repairosome" EXACT []
is_obsolete: true
replaced_by: GO:0000109

[Term]
id: GO:0000109
name: nucleotide-excision repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862]
comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
subset: goslim_pir
synonym: "UvrB-UvrC complex" NARROW [PMID:12145219]
synonym: "UvrBC complex" NARROW [GOC:bhm, PMID:12145219]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0000110
name: nucleotide-excision repair factor 1 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF1 complex" EXACT []
synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000111
name: nucleotide-excision repair factor 2 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF2 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000112
name: nucleotide-excision repair factor 3 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF3 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000113
name: nucleotide-excision repair factor 4 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF4 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000114
name: obsolete regulation of transcription involved in G1 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "G1-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT []
synonym: "regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0000115
name: obsolete regulation of transcription involved in S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED []
synonym: "regulation of transcription involved in S phase of mitotic cell cycle" EXACT []
synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT []
synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED []
synonym: "S-specific transcription in mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0000116
name: obsolete regulation of transcription involved in G2-phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "G2-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED []
synonym: "regulation of transcription involved in G2-phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0000117
name: obsolete regulation of transcription involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle" RELATED []
is_obsolete: true
consider: GO:0000086
consider: GO:0006357

[Term]
id: GO:0000118
name: histone deacetylase complex
namespace: cellular_component
def: "A protein complex that possesses histone deacetylase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.
synonym: "HDAC complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0000120
name: RNA polymerase I transcription regulator complex
namespace: cellular_component
def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I." [GOC:mah]
synonym: "RNA polymerase I transcription factor complex" NARROW []
is_a: GO:0005667 ! transcription regulator complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0000121
name: glycerol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sn-glycerol 1-phosphate = glycerol + phosphate." [RHEA:46084]
synonym: "alpha-glycerol phosphatase activity" RELATED [EC:3.1.3.21]
synonym: "alpha-glycerophosphatase activity" RELATED [EC:3.1.3.21]
synonym: "glycerol 3-phosphatase activity" RELATED [EC:3.1.3.21]
synonym: "glycerol 3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.21]
synonym: "glycerol-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.21]
synonym: "glycerol-3-phosphate phosphatase activity" RELATED [EC:3.1.3.21]
xref: RHEA:46084
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0000122
name: negative regulation of transcription by RNA polymerase II
namespace: biological_process
alt_id: GO:0010553
alt_id: GO:0045816
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]
synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED []
synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT []
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "negative regulation of global transcription from Pol II promoter" RELATED []
synonym: "negative regulation of transcription from Pol II promoter" EXACT []
synonym: "negative regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED []
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
relationship: negatively_regulates GO:0006366 ! transcription by RNA polymerase II

[Term]
id: GO:0000123
name: histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
comment: Note that this term represents a protein complex, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "histone acetylase complex" EXACT []
is_a: GO:0031248 ! protein acetyltransferase complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0000124
name: SAGA complex
namespace: cellular_component
alt_id: GO:0000125
alt_id: GO:0030914
def: "A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]
synonym: "PCAF complex" NARROW []
synonym: "PCAF histone acetylase-associated complex" NARROW []
synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT []
synonym: "SPT3-TAF9-GCN5 acetylase complex" RELATED [GOC:rl, PMID:18838386]
synonym: "SPT3-TAF9-PCAF acetylase complex" NARROW [PMID:18838386]
synonym: "STAGA coactivator complex" RELATED []
synonym: "STAGA complex" RELATED [PMID:32616828, PMID:33004486, PMID:34112237]
is_a: GO:0070461 ! SAGA-type complex
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:0000126
name: transcription factor TFIIIB complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012]
is_a: GO:0090576 ! RNA polymerase III transcription regulator complex

[Term]
id: GO:0000127
name: transcription factor TFIIIC complex
namespace: cellular_component
def: "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions." [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097]
is_a: GO:0090576 ! RNA polymerase III transcription regulator complex

[Term]
id: GO:0000128
name: flocculation
namespace: biological_process
alt_id: GO:0000501
alt_id: GO:0032128
alt_id: GO:0036281
alt_id: GO:0036282
alt_id: GO:0043689
alt_id: GO:0043690
def: "The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs." [GOC:jl, GOC:vw, PMID:11472912, PMID:21114594, PMID:8740415]
comment: The word floc derives from the Latin word floccus, which means a tuft of wool.
subset: goslim_pir
synonym: "cell-cell adhesion involved in flocculation" EXACT []
synonym: "cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction" NARROW []
synonym: "co-flocculation" NARROW [PMID:10689163]
synonym: "coflocculation" NARROW []
synonym: "coflocculation via lectin-mannose interaction" NARROW [PMID:11693916]
synonym: "coflocculation via protein-carbohydrate interaction" NARROW []
synonym: "flocculation via cell wall protein-carbohydrate interaction" RELATED []
synonym: "flocculation via extracellular polymer" RELATED []
xref: Wikipedia:Flocculation
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms
is_a: GO:0098610 ! adhesion between unicellular organisms

[Term]
id: GO:0000131
name: incipient cellular bud site
namespace: cellular_component
def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt]
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0000132
name: establishment of mitotic spindle orientation
namespace: biological_process
alt_id: GO:0030607
alt_id: GO:0030609
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "mitotic spindle orientation" EXACT []
synonym: "orienting of mitotic spindle" EXACT []
is_a: GO:0040001 ! establishment of mitotic spindle localization
is_a: GO:0051294 ! establishment of spindle orientation

[Term]
id: GO:0000133
name: polarisome
namespace: cellular_component
def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0030427 ! site of polarized growth

[Term]
id: GO:0000136
name: mannan polymerase complex
namespace: cellular_component
def: "A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825]
synonym: "alpha-1,6-mannosyltransferase complex" EXACT []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0000137 ! Golgi cis cisterna
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0000137
name: Golgi cis cisterna
namespace: cellular_component
def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
synonym: "Golgi apparatus cis cisterna" EXACT []
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000138
name: Golgi trans cisterna
namespace: cellular_component
def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
synonym: "late Golgi" RELATED [GOC:mah]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000139
name: Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
synonym: "Golgi apparatus membrane" EXACT []
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0000140
name: acylglycerone-phosphate reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hexadecanoyl-sn-glycero-3-phosphate + NADP+ = 1-hexadecanoylglycerone 3-phosphate + H+ + NADPH." [RHEA:17341]
synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT []
synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.101]
synonym: "acyldihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.101]
synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.101]
synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" RELATED [EC:1.1.1.101]
synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" RELATED [EC:1.1.1.101]
xref: EC:1.1.1.101
xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN
xref: Reactome:R-HSA-75883 "DHRS7B reduces GO3P to HXDG3P"
xref: RHEA:17341
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000142
name: cellular bud neck contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555]
synonym: "neck ring" EXACT []
is_a: GO:0110085 ! mitotic actomyosin contractile ring
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000144
name: cellular bud neck septin ring
namespace: cellular_component
def: "A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure

[Term]
id: GO:0000145
name: exocyst
namespace: cellular_component
def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]
synonym: "exocyst complex" EXACT []
synonym: "Sec6/8 complex" EXACT []
xref: Wikipedia:Exocyst
is_a: GO:0099023 ! vesicle tethering complex
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0000146
name: microfilament motor activity
namespace: molecular_function
alt_id: GO:0030898
def: "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]
synonym: "actin filament motor activity" EXACT [GOC:dph]
synonym: "actin-activated ATPase activity" EXACT []
synonym: "actin-dependent ATPase activity" EXACT []
synonym: "actin-filament motor activity" EXACT []
synonym: "muscle motor activity" NARROW []
synonym: "myosin ATPase activity" RELATED []
xref: EC:5.6.1.8
xref: Reactome:R-HSA-2316352 "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane"
xref: Reactome:R-HSA-432237 "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane"
xref: Reactome:R-HSA-9023171 "Insulin secretory granule translocates across the cortical actin network"
is_a: GO:0003774 ! cytoskeletal motor activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0000147
name: actin cortical patch assembly
namespace: biological_process
def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0044396 ! actin cortical patch organization

[Term]
id: GO:0000148
name: 1,3-beta-D-glucan synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain." [PMID:7983071]
synonym: "(1->3)-beta-glucan synthase complex" EXACT [GOC:tb]
synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb]
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0000149
name: SNARE binding
namespace: molecular_function
def: "Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
subset: goslim_chembl
synonym: "SNAP receptor binding" EXACT []
xref: Reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming"
xref: Reactome:R-HSA-210430 "Release of L-Glutamate at the synapse"
xref: Reactome:R-HSA-265166 "Exocytosis of Insulin"
xref: Reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming"
xref: Reactome:R-HSA-372529 "Release of acetylcholine at the synapse"
xref: Reactome:R-HSA-374899 "Release of noradrenaline  at the synapse"
xref: Reactome:R-HSA-374922 "Noradrenalin synaptic vesicle docking and priming"
xref: Reactome:R-HSA-376357 "Vamp7 associated Lysosome to Plasma membrane transport"
xref: Reactome:R-HSA-376364 "Vamp8 associated secretory vesicle to plasma membrane transport"
xref: Reactome:R-HSA-376369 "Vamp2 associated secretory vesicle to plasma membrane transport"
xref: Reactome:R-HSA-380574 "Dopamine synaptic vesicle docking and priming"
xref: Reactome:R-HSA-380869 "Release of docked dopamine loaded synaptic vesicle"
xref: Reactome:R-HSA-380901 "Release of docked serotonin loaded synaptic vesicle"
xref: Reactome:R-HSA-380905 "Serotonin loaded synaptic vesicle docking and priming"
xref: Reactome:R-HSA-888589 "Release of GABA at the synapse"
xref: Reactome:R-HSA-9023173 "Insulin secretory granule docks at the plasma membrane"
xref: Reactome:R-HSA-917744 "GABA loaded synaptic vesicle Docking and Priming"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0000150
name: DNA strand exchange activity
namespace: molecular_function
def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]
comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'.
subset: goslim_metagenomics
synonym: "RecA-family recombinase activity" RELATED []
synonym: "recombinase activity" EXACT []
synonym: "strand exchange activity" RELATED []
synonym: "strand transferase" NARROW []
xref: Reactome:R-HSA-912458 "Formation of meiotic heteroduplex"
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0000151
name: ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
subset: goslim_pir
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0000152
name: nuclear ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0000153
name: cytoplasmic ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000154
name: rRNA modification
namespace: biological_process
alt_id: GO:0016548
def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
synonym: "rRNA editing" NARROW [GOC:hjd]
is_a: GO:0006364 ! rRNA processing
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0000155
name: phosphorelay sensor kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:31386843, PMID:9191038]
synonym: "two-component sensor activity" NARROW []
synonym: "two-component sensor molecule" NARROW []
synonym: "two-component system sensor activity" NARROW []
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0000156
name: phosphorelay response regulator activity
namespace: molecular_function
def: "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
synonym: "two-component response regulator activity" NARROW []
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0000159
name: protein phosphatase type 2A complex
namespace: cellular_component
def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
synonym: "PP2A complex" EXACT []
synonym: "PP2A-pi" NARROW []
synonym: "PP2a-protector" NARROW []
synonym: "protein phosphatase 2 complex" RELATED [GOC:dph, GOC:rl]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex

[Term]
id: GO:0000160
name: phosphorelay signal transduction system
namespace: biological_process
def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]
subset: goslim_metagenomics
synonym: "histidyl-aspartyl phosphorelay" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0000161
name: obsolete osmosensory signaling MAPK cascade
namespace: biological_process
alt_id: GO:0000167
alt_id: GO:0000168
alt_id: GO:0000169
alt_id: GO:0000173
alt_id: GO:0007233
def: "OBSOLETE. A MAPK cascade that starts with the activation of a Ssk2/Win1 family MAP3K, which activates a Pbs2/Wis1 family MAP2K, resulting in the activation of a Hog1/Sty1 family MAPK. Hog1 then translocates from the cytosol into the nucleus where it affects the expression of a large number of genes. This cascade is activated by hyperosmolarity or other abiotic stresses and results in cellular responses such as cell cycle arrest." [PMID:17604854, PMID:32794416, PMID:9561267]
comment: This term was obsoleted because it represents the same process as p38MAPK cascade ; GO:0038066.
synonym: "activation of MAPK activity involved in osmosensory signaling pathway" NARROW []
synonym: "activation of MAPKK activity during osmolarity sensing" NARROW []
synonym: "activation of MAPKK activity involved in osmosensory signaling pathway" NARROW []
synonym: "activation of MAPKKK activity during osmolarity sensing" NARROW []
synonym: "activation of MAPKKK activity involved in osmosensory signaling pathway" NARROW []
synonym: "activation of Pbs2 kinase" NARROW []
synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736]
synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736]
synonym: "Hog1/Sty1 stress-activated MAPK cascade" NARROW []
synonym: "inactivation of MAPK activity involved in osmosensory signaling pathway" NARROW []
synonym: "MAPK cascade involved in osmosensory signaling pathway" EXACT []
synonym: "MAPKKK cascade during osmolarity sensing" EXACT []
synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling]
synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, activation of MAP kinase kinase activity" NARROW []
synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" NARROW []
synonym: "osmolarity sensing, activation of MAPK activity" NARROW []
synonym: "osmolarity sensing, activation of MAPKK activity" NARROW []
synonym: "osmolarity sensing, activation of MAPKKK activity" NARROW []
synonym: "osmolarity sensing, MAPKKK cascade" EXACT []
synonym: "termination of MAPK activity during osmolarity sensing" NARROW []
is_obsolete: true
replaced_by: GO:0038066

[Term]
id: GO:0000162
name: tryptophan biosynthetic process
namespace: biological_process
alt_id: GO:0009096
def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY]
synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT []
synonym: "tryptophan anabolism" EXACT []
synonym: "tryptophan biosynthesis" EXACT []
synonym: "tryptophan formation" EXACT []
synonym: "tryptophan synthesis" EXACT []
xref: MetaCyc:TRPSYN-PWY
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0046219 ! indolalkylamine biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0000164
name: protein phosphatase type 1 complex
namespace: cellular_component
def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000165
name: MAPK cascade
namespace: biological_process
alt_id: GO:0007255
def: "An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]
comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
synonym: "ERK/MAPK cascade" NARROW []
synonym: "MAP kinase cascade" EXACT []
synonym: "MAP kinase kinase kinase cascade" EXACT []
synonym: "MAPK signal transduction" EXACT [GOC:signaling]
synonym: "MAPK signaling" RELATED []
synonym: "MAPK signalling" RELATED []
synonym: "MAPKKK cascade" EXACT []
synonym: "MAPKKK cascade during sporulation" NARROW []
synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf]
xref: Wikipedia:MAPK_cascade
xref: Wikipedia:Mitogen-activated_protein_kinase
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0000166
name: nucleotide binding
namespace: molecular_function
def: "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
is_a: GO:1901265 ! nucleoside phosphate binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0000170
name: sphingosine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590]
xref: Reactome:R-HSA-428260 "DEGS2 oxygenates dihydroceramide"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0000171
name: ribonuclease MRP activity
namespace: molecular_function
def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380]
synonym: "RNase MRP" EXACT []
xref: Wikipedia:RNase_MRP
is_a: GO:0004521 ! RNA endonuclease activity

[Term]
id: GO:0000172
name: ribonuclease MRP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714]
synonym: "ribonuclease mitochondrial RNA processing complex" EXACT []
synonym: "RNase MRP complex" EXACT []
is_a: GO:0005732 ! sno(s)RNA-containing ribonucleoprotein complex
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0000174
name: obsolete inactivation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0000175
name: 3'-5'-RNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
synonym: "3'-5' exoribonuclease activity" EXACT []
synonym: "3'-5'-exoribonuclease activity" EXACT []
xref: Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion"
xref: Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA"
xref: Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA"
xref: Reactome:R-HSA-9682603 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA"
xref: Reactome:R-HSA-9694632 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA"
xref: Reactome:R-HSA-9822437 "DIS3L2 hydrolyzes uridylated mRNA"
xref: Reactome:R-HSA-9836585 "SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides"
xref: Reactome:R-HSA-9836822 "REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides"
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016896 ! RNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0000176
name: nuclear exosome (RNase complex)
namespace: cellular_component
def: "A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]
synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT []
synonym: "nuclear exosome (ribonuclease complex)" EXACT []
synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0000177
name: cytoplasmic exosome (RNase complex)
namespace: cellular_component
def: "A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]
synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT []
synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT []
synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000178
name: exosome (RNase complex)
namespace: cellular_component
def: "A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]
comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
subset: goslim_pir
synonym: "exosome (ribonucleasease complex)" EXACT []
synonym: "exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:1905354 ! exoribonuclease complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0000179
name: rRNA (adenine-N6,N6-)-dimethyltransferase activity
namespace: molecular_function
alt_id: GO:0043790
def: "Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]
synonym: "18S rRNA dimethylase activity" EXACT []
synonym: "dimethyladenosine transferase activity" EXACT []
synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT []
xref: Reactome:R-HSA-6790994 "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851"
xref: Reactome:R-HSA-6793066 "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0000180
name: obsolete cytosolic large ribosomal subunit
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
synonym: "cytosolic large ribosomal subunit" EXACT []
is_obsolete: true
consider: GO:0022625

[Term]
id: GO:0000181
name: obsolete cytosolic small ribosomal subunit
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
synonym: "cytosolic small ribosomal subunit" EXACT []
is_obsolete: true
consider: GO:0022627

[Term]
id: GO:0000182
name: rDNA binding
namespace: molecular_function
def: "Binding to a DNA sequence encoding a ribosomal RNA." [GOC:mah]
synonym: "ribosomal DNA binding" EXACT []
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0000183
name: rDNA heterochromatin formation
namespace: biological_process
def: "The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3." [PMID:10219245]
synonym: "chromatin silencing at rDNA" RELATED []
synonym: "chromatin silencing at ribosomal DNA" BROAD []
synonym: "heterochromatic silencing at rDNA" BROAD []
synonym: "rDNA chromatin silencing" BROAD [GOC:mah]
synonym: "rDNA heterochromatin assembly" EXACT []
is_a: GO:0140718 ! facultative heterochromatin formation
relationship: part_of GO:1990700 ! nucleolar chromatin organization

[Term]
id: GO:0000184
name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
synonym: "mRNA breakdown, nonsense-mediated decay" EXACT []
synonym: "mRNA catabolic process, nonsense-mediated" EXACT []
synonym: "mRNA catabolism, nonsense-mediated" EXACT []
synonym: "mRNA degradation, nonsense-mediated decay" EXACT []
synonym: "nonsense-mediated mRNA decay" EXACT []
synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT []
xref: Wikipedia:Nonsense-mediated_decay
xref: Wikipedia:Nonsense-mediated_mRNA_decay
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000185
name: obsolete activation of MAPKKK activity
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK)." [PMID:9561267]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of MAP kinase kinase kinase" EXACT []
synonym: "activation of MAP3K activity" EXACT [GOC:bf]
synonym: "activation of MAPKKK activity during sporulation" NARROW []
synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD []
synonym: "positive regulation of MAPKKK activity" BROAD []
is_obsolete: true
consider: GO:0000165
consider: GO:0043539

[Term]
id: GO:0000186
name: obsolete activation of MAPKK activity
namespace: biological_process
def: "OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK)." [PMID:9561267]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of MAP kinase kinase activity" EXACT []
synonym: "activation of MAP/ERK kinase kinase" EXACT []
synonym: "activation of MAP2K activity" EXACT [GOC:bf]
synonym: "activation of MAPKK activity during sporulation" NARROW []
synonym: "positive regulation of MAPKK activity" BROAD []
is_obsolete: true
consider: GO:0000165
consider: GO:0043539

[Term]
id: GO:0000187
name: obsolete activation of MAPK activity
namespace: biological_process
def: "OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of MAP kinase" EXACT []
synonym: "activation of MAPK activity during sporulation" NARROW []
synonym: "MAPK activation" EXACT []
is_obsolete: true
consider: GO:0000165
consider: GO:0043539

[Term]
id: GO:0000188
name: obsolete inactivation of MAPK activity
namespace: biological_process
def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267]
comment: This term was obsoleted because it represents a molecular function.
synonym: "inactivation of MAPK during sporulation" NARROW []
synonym: "termination of MAPK activity" EXACT []
is_obsolete: true
consider: GO:0000165
consider: GO:0043539

[Term]
id: GO:0000189
name: obsolete MAPK import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "nuclear translocation of MAPK" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0000190
name: obsolete MAPKKK cascade (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000191
name: obsolete activation of MAPKKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000192
name: obsolete activation of MAPKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000193
name: obsolete activation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000194
name: obsolete inactivation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000195
name: obsolete nuclear translocation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000196
name: cell integrity MAPK cascade
namespace: biological_process
def: "A MAPK cascade that specifically ensures the maintenance and regulation of cellular structure in response to external signals, including plasma membrane stretching or cell wall alteration, to coordinate cellular responses such as growth, differentiation, and stress adaptation, thereby preserving cell integrity. Contains the  SLT2 (S.cerevisiae)/Pmk1 (S.pombe) MAP kinase or orthologs." [GOC:vw]
synonym: "cell integrity MAPK pathway" EXACT [GOC:vw, PMID:23934882]
synonym: "cell wall integrity MAPK cascade" NARROW []
synonym: "CWI pathway" RELATED []
synonym: "Mpk1 cascade" NARROW [PMID:10523653]
synonym: "Pmk1 MAPK cell integrity signaling" NARROW [PMID:20032302]
synonym: "Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [PMID:23934882]
synonym: "PMK1-MAPK signal transduction pathway" NARROW [PMID:23454094]
synonym: "Slt2 cascade" NARROW [PMID:10523653]
is_a: GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0000197
name: obsolete activation of MAPKKK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "activation of MAPKKK activity involved in cell wall biogenesis" RELATED []
synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT []
is_obsolete: true
consider: GO:0000165
consider: GO:0043539

[Term]
id: GO:0000198
name: obsolete activation of MAPKK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "activation of MAPKK activity involved in cell wall biogenesis" RELATED []
synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT []
is_obsolete: true

[Term]
id: GO:0000199
name: obsolete activation of MAPK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of MAPK activity involved in cell wall biogenesis" NARROW []
synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAPK activity" EXACT []
is_obsolete: true

[Term]
id: GO:0000200
name: obsolete inactivation of MAPK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis." [PMID:9561267]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT []
synonym: "cell wall biogenesis, termination of MAPK activity" EXACT []
synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "inactivation of MAPK activity involved in cell wall organization or biogenesis" RELATED []
synonym: "termination of MAPK activity during cell wall biogenesis" EXACT []
is_obsolete: true

[Term]
id: GO:0000201
name: obsolete MAPK import into nucleus involved in cell wall organization or biogenesis
namespace: biological_process
def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis." [PMID:9561267]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah]
synonym: "MAPK import into nucleus involved in cell wall biogenesis" NARROW [GOC:vw]
synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah]
synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah]
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0000202
name: obsolete MAPKKK cascade during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000203
name: obsolete activation of MAPKKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000204
name: obsolete activation of MAPKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000205
name: obsolete activation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000206
name: obsolete inactivation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000207
name: obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000208
name: obsolete MAPK import into nucleus involved in osmosensory signaling pathway
namespace: biological_process
def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah]
synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT []
synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah]
synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0000209
name: protein polyubiquitination
namespace: biological_process
def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [PMID:26906419]
synonym: "polyubiquitin" RELATED []
synonym: "protein polyubiquitinylation" EXACT []
synonym: "protein polyubiquitylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0000210
name: NAD+ diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [RHEA:11800]
synonym: "NAD diphosphatase activity" BROAD []
synonym: "NAD pyrophosphatase activity" BROAD []
synonym: "NAD(+) pyrophosphatase activity" EXACT []
synonym: "NAD+ phosphohydrolase activity" EXACT []
synonym: "NAD+ pyrophosphatase activity" EXACT []
synonym: "NADP pyrophosphatase activity" RELATED [EC:3.6.1.22]
synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.22]
xref: MetaCyc:NADPYROPHOSPHAT-RXN
xref: RHEA:11800
is_a: GO:0004551 ! dinucleotide phosphatase activity

[Term]
id: GO:0000211
name: obsolete protein degradation tagging activity
namespace: molecular_function
def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194]
comment: This term was made obsolete because it represents a biological process and a molecular function.
synonym: "protein degradation tagging activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0019941

[Term]
id: GO:0000212
name: meiotic spindle organization
namespace: biological_process
alt_id: GO:0043147
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah]
synonym: "meiotic spindle organisation" EXACT []
synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "meiotic spindle stabilization" RELATED []
synonym: "spindle organization during meiosis" EXACT [GOC:mah]
is_a: GO:0007051 ! spindle organization
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0000213
name: tRNA-intron endonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:4.6.1.16]
synonym: "tRNA splicing endonuclease activity" RELATED [EC:4.6.1.16]
synonym: "tRNA-intron endoribonuclease activity" EXACT []
xref: EC:4.6.1.16
xref: MetaCyc:3.1.27.9-RXN
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016892 ! RNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0000214
name: tRNA-intron endonuclease complex
namespace: cellular_component
def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [PMID:22391451]
synonym: "SEN complex" EXACT [GOC:se, PMID:22391451]
synonym: "tRNA splicing endonuclease complex" EXACT [GOC:se, PMID:22391451]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0000215
name: tRNA 2'-phosphotransferase activity
namespace: molecular_function
alt_id: GO:0008665
def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937]
subset: goslim_chembl
synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" RELATED [EC:2.7.1.160]
synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" RELATED [EC:2.7.1.160]
synonym: "2'-phosphotransferase activity" BROAD []
synonym: "Tpt1" RELATED [EC:2.7.1.160]
synonym: "Tpt1p" RELATED [EC:2.7.1.160]
synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160]
xref: EC:2.7.1.160
xref: MetaCyc:2.7.1.160-RXN
xref: RHEA:23324
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0000216
name: obsolete M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "M/G1 transition of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0000217
name: DNA secondary structure binding
namespace: molecular_function
def: "Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction." [GOC:krc]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0000219
name: obsolete vacuolar hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "V-ATPase" EXACT []
synonym: "vacuolar hydrogen-transporting ATPase" EXACT []
is_obsolete: true
consider: GO:0016469

[Term]
id: GO:0000220
name: vacuolar proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit.
synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000221
name: vacuolar proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain generally consists of eight subunits.
synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000222
name: plasma membrane proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000223
name: plasma membrane proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000224
name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52]
synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52]
synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52]
synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52]
synonym: "N-glycanase activity" RELATED [EC:3.5.1.52]
synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.52]
synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52]
synonym: "peptide:N-glycanase" RELATED []
synonym: "PNGase" EXACT []
synonym: "PNGase A" RELATED [EC:3.5.1.52]
synonym: "PNGase F" RELATED [EC:3.5.1.52]
xref: EC:3.5.1.52
xref: MetaCyc:3.5.1.52-RXN
xref: Reactome:R-HSA-8850594 "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0000225
name: N-acetylglucosaminylphosphatidylinositol deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89]
synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" RELATED [EC:3.5.1.89]
synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" RELATED [EC:3.5.1.89]
synonym: "GlcNAc-PI de-N-acetylase activity" RELATED [EC:3.5.1.89]
synonym: "GlcNAc-PI deacetylase activity" RELATED [EC:3.5.1.89]
synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" RELATED [EC:3.5.1.89]
synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" RELATED [EC:3.5.1.89]
xref: EC:3.5.1.89
xref: MetaCyc:3.1.1.69-RXN
xref: Reactome:R-HSA-162857 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate"
xref: RHEA:11660
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_pombe
synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0000227
name: obsolete oxaloacetate secondary active transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "oxaloacetate carrier activity" RELATED []
is_obsolete: true
consider: GO:0015131

[Term]
id: GO:0000228
name: nuclear chromosome
namespace: cellular_component
def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "nuclear interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0000229
name: obsolete cytoplasmic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "cytoplasmic interphase chromosome" NARROW []
is_obsolete: true
replaced_by: GO:0005694

[Term]
id: GO:0000230
name: obsolete nuclear mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "nuclear mitotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000794

[Term]
id: GO:0000231
name: obsolete cytoplasmic mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "cytoplasmic mitotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000793

[Term]
id: GO:0000232
name: obsolete nuclear interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "nuclear interphase chromosome" EXACT []
is_obsolete: true
consider: GO:0000228

[Term]
id: GO:0000233
name: obsolete cytoplasmic interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "cytoplasmic interphase chromosome" EXACT []
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0000234
name: phosphoethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103]
synonym: "phosphoethanolamine methyltransferase activity" RELATED [EC:2.1.1.103]
synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" RELATED [EC:2.1.1.103]
xref: EC:2.1.1.103
xref: KEGG_REACTION:R02037
xref: KEGG_REACTION:R06868
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000235
name: astral microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
is_a: GO:0005876 ! spindle microtubule
is_a: GO:0005881 ! cytoplasmic microtubule
relationship: part_of GO:0005818 ! aster

[Term]
id: GO:0000236
name: mitotic prometaphase
namespace: biological_process
def: "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000087 ! mitotic M phase

[Term]
id: GO:0000237
name: leptotene
namespace: biological_process
def: "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Leptotene
xref: Wikipedia:Meiosis#Leptotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000238
name: zygotene
namespace: biological_process
def: "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Meiosis#Zygotene
xref: Wikipedia:Zygotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000239
name: pachytene
namespace: biological_process
def: "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Meiosis#Pachytene
xref: Wikipedia:Pachytene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000240
name: diplotene
namespace: biological_process
def: "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Diplotene
xref: Wikipedia:Meiosis#Diplotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000241
name: diakinesis
namespace: biological_process
def: "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Diakinesis
xref: Wikipedia:Meiosis#Diakinesis
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000242
name: pericentriolar material
namespace: cellular_component
def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0000243
name: commitment complex
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140]
synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah]
synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex

[Term]
id: GO:0000244
name: spliceosomal tri-snRNP complex assembly
namespace: biological_process
alt_id: GO:0000351
alt_id: GO:0000355
def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384]
synonym: "assembly of spliceosomal tri-snRNP" EXACT []
synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW []
synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW []
synonym: "snRNP recycling" BROAD []
synonym: "spliceosomal tri-snRNP assembly" EXACT []
synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW []
synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW []
is_a: GO:0000387 ! spliceosomal snRNP assembly

[Term]
id: GO:0000245
name: spliceosomal complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]
synonym: "spliceosome assembly" BROAD []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000246
name: Delta24(24-1) sterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H+ + NADPH." [EC:1.3.1.71, RHEA:18501]
synonym: "C-24(28) sterol reductase activity" RELATED [EC:1.3.1.71]
synonym: "D24(24-1)-sterol reductase activity" EXACT []
synonym: "delta24(241)-sterol reductase activity" RELATED [EC:1.3.1.71]
synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" RELATED [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-methylene reductase activity" RELATED [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-reductase activity" RELATED [EC:1.3.1.71]
synonym: "sterol delta-24(28) methylene reductase activity" EXACT []
synonym: "sterol delta-24(28) reductase activity" EXACT []
synonym: "sterol delta24(28)-methylene reductase activity" RELATED [EC:1.3.1.71]
synonym: "sterol delta24(28)-reductase activity" RELATED [EC:1.3.1.71]
xref: EC:1.3.1.71
xref: KEGG_REACTION:R05641
xref: MetaCyc:1.3.1.71-RXN
xref: RHEA:18501
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000247
name: C-8 sterol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: fecosterol = episterol." [PMID:8988026, RHEA:33435]
synonym: "delta-8-delta-7 sterol isomerase activity" EXACT []
xref: MetaCyc:RXN3O-203
xref: RHEA:33435
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0000248
name: C-5 sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [GOC:curators]
synonym: "sterol-C5-desaturase activity" EXACT []
xref: Reactome:R-HSA-195664 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol"
xref: Reactome:R-HSA-6807053 "SC5D desaturates LTHSOL to 7-dehydroCHOL"
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000249
name: C-22 sterol desaturase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydroepisterol + H+ + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP+. This reaction is the introduction of a double bond between the C-22 and C-23 carbons of certain sterols. Also converts sitosterol and 24-epi-campesterol to stigmasterol and brassicasterol, respectively." [EC:1.14.19.41]
xref: EC:1.14.19.41
xref: MetaCyc:RXN3O-227
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000250
name: lanosterol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14621]
synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" RELATED [EC:5.4.99.7]
synonym: "2,3-epoxysqualene lanosterol cyclase activity" RELATED [EC:5.4.99.7]
synonym: "2,3-epoxysqualene--lanosterol cyclase activity" RELATED [EC:5.4.99.7]
synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT []
synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7]
synonym: "2,3-oxidosqualene-lanosterol cyclase activity" RELATED [EC:5.4.99.7]
synonym: "lanosterol 2,3-oxidosqualene cyclase activity" RELATED [EC:5.4.99.7]
synonym: "OSC" EXACT []
synonym: "oxidosqualene--lanosterol cyclase activity" RELATED [EC:5.4.99.7]
synonym: "oxidosqualene-lanosterol cyclase activity" EXACT []
synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581]
synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" RELATED [EC:5.4.99.7]
synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7]
synonym: "squalene-2,3-oxide-lanosterol cyclase activity" RELATED [EC:5.4.99.7]
xref: EC:5.4.99.7
xref: KEGG_REACTION:R03199
xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN
xref: Reactome:R-HSA-191366 "Squalene 2,3-epoxide cyclizes, forming lanosterol"
xref: RHEA:14621
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0000252
name: 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxysteroid-4-alpha-carboxylate + NADP+ = a 3-oxosteroid + CO2 + NADPH." [EC:1.1.1.170, PMID:9811880]
synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170]
synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT []
synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED []
synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED []
synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED []
synonym: "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" EXACT []
synonym: "C-3 sterol dehydrogenase activity" RELATED []
synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED []
synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED []
synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED []
xref: EC:1.1.1.170
xref: Reactome:R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one"
xref: Reactome:R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000253
name: 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity
namespace: molecular_function
alt_id: GO:0050576
def: "Catalysis of the reaction: a 3-beta-hydroxysteroid + NADP+ = a 3-oxosterol + NADPH + H+." [EC:1.1.1.270, GOC:mah, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3-keto sterol reductase activity" EXACT []
synonym: "3-keto-steroid reductase activity" EXACT []
synonym: "3-KSR activity" RELATED [EC:1.1.1.270]
synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270]
xref: EC:1.1.1.270
xref: MetaCyc:RXN-13686
xref: Reactome:R-HSA-194632 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)"
xref: Reactome:R-HSA-194689 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol"
xref: RHEA:34787
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000254
name: C-4 methylsterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O." [PMID:9811880, RHEA:55220]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "4-methylsterol oxidase activity" EXACT [EC:1.14.18.9]
synonym: "methylsterol hydroxylase activity" RELATED [EC:1.14.18.9]
synonym: "methylsterol monooxygenase activity" RELATED [EC:1.14.18.9]
xref: EC:1.14.18.9
xref: MetaCyc:RXN-13188
xref: Reactome:R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol"
xref: Reactome:R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol"
xref: RHEA:55220
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0000255
name: allantoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684]
synonym: "allantoin metabolism" EXACT []
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0000256
name: allantoin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684]
synonym: "allantoin breakdown" EXACT []
synonym: "allantoin catabolism" EXACT []
synonym: "allantoin degradation" EXACT []
is_a: GO:0000255 ! allantoin metabolic process
is_a: GO:0043605 ! amide catabolic process

[Term]
id: GO:0000257
name: nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd]
synonym: "acetonitrilase activity" RELATED [EC:3.5.5.1]
synonym: "benzonitrilase activity" RELATED [EC:3.5.5.1]
synonym: "nitrile aminohydrolase activity" RELATED [EC:3.5.5.1]
xref: EC:3.5.5.1
xref: KEGG_REACTION:R00540
xref: MetaCyc:3.5.5.1-RXN
xref: RHEA:21724
xref: UM-BBD_reactionID:r0377
xref: UM-BBD_reactionID:r0701
is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

[Term]
id: GO:0000258
name: obsolete isoleucine/valine:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "isoleucine/valine:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005283
consider: GO:0005304
consider: GO:0015188

[Term]
id: GO:0000259
name: obsolete intracellular nucleoside transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai]
comment: This term was made obsolete because it contains component and function information.
synonym: "intracellular nucleoside transmembrane transporter activity" EXACT []
is_obsolete: true
consider: GO:0005337
consider: GO:0005622

[Term]
id: GO:0000260
name: obsolete hydrogen-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "hydrogen-translocating V-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046961

[Term]
id: GO:0000261
name: obsolete sodium-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "sodium-translocating V-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046962

[Term]
id: GO:0000262
name: mitochondrial chromosome
namespace: cellular_component
def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah]
synonym: "mitochondrial DNA" NARROW []
synonym: "mitochondrial genome" RELATED []
synonym: "mtDNA" NARROW []
xref: NIF_Subcellular:sao1186327184
is_a: GO:0005694 ! chromosome
relationship: part_of GO:0042645 ! mitochondrial nucleoid

[Term]
id: GO:0000263
name: obsolete heterotrimeric G-protein GTPase, alpha-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000264
name: obsolete heterotrimeric G-protein GTPase, beta-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "heterotrimeric G-protein GTPase, beta-subunit" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000265
name: obsolete heterotrimeric G-protein GTPase, gamma-subunit
namespace: molecular_function
def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000266
name: mitochondrial fission
namespace: biological_process
def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
synonym: "mitochondrial division" EXACT []
synonym: "mitochondrial proliferation" RELATED []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000267
name: obsolete cell fraction
namespace: cellular_component
def: "OBSOLETE. A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "cell fraction" EXACT []
is_obsolete: true
consider: GO:0005575

[Term]
id: GO:0000268
name: peroxisome targeting sequence binding
namespace: molecular_function
alt_id: GO:0005051
def: "Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome." [GOC:mah, ISBN:0879693568]
synonym: "peroxisome targeting signal receptor" NARROW []
synonym: "PTS binding" EXACT []
synonym: "PTS receptor" NARROW []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0000269
name: toxin export channel activity
namespace: molecular_function
def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0015288 ! porin activity
is_a: GO:0019534 ! toxin transmembrane transporter activity

[Term]
id: GO:0000270
name: peptidoglycan metabolic process
namespace: biological_process
alt_id: GO:0009284
def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [ISBN:0198506732, PMID:33139480]
synonym: "murein metabolic process" EXACT []
synonym: "murein metabolism" EXACT []
synonym: "peptidoglycan metabolism" EXACT []
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0000271
name: polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators]
synonym: "glycan biosynthesis" EXACT []
synonym: "glycan biosynthetic process" EXACT []
synonym: "polysaccharide anabolism" EXACT []
synonym: "polysaccharide biosynthesis" EXACT []
synonym: "polysaccharide formation" EXACT []
synonym: "polysaccharide synthesis" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0000272
name: polysaccharide catabolic process
namespace: biological_process
alt_id: GO:0044244
def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]
synonym: "multicellular organismal polysaccharide catabolic process" NARROW []
synonym: "polysaccharide breakdown" EXACT []
synonym: "polysaccharide catabolism" EXACT []
synonym: "polysaccharide degradation" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0000274
name: obsolete mitochondrial proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "OBSOLETE. One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "mitochondrial proton-transporting ATP synthase, peripheral stalk" EXACT []
is_obsolete: true
replaced_by: GO:0045265

[Term]
id: GO:0000275
name: obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
namespace: cellular_component
def: "OBSOLETE. The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.\nThe reason for obsoletion is that this term unnecssarily specified a cellular compartment
synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD []
is_obsolete: true
replaced_by: GO:0045261

[Term]
id: GO:0000276
name: obsolete mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "OBSOLETE. All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045263

[Term]
id: GO:0000277
name: [cytochrome c]-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59]
synonym: "cytochrome c (lysine) methyltransferase activity" RELATED [EC:2.1.1.59]
synonym: "cytochrome c methyltransferase activity" RELATED [EC:2.1.1.59]
synonym: "cytochrome c-lysine N-methyltransferase activity" RELATED [EC:2.1.1.59]
synonym: "cytochrome c-specific protein methylase III activity" RELATED [EC:2.1.1.59]
synonym: "cytochrome c-specific protein-lysine methyltransferase activity" RELATED [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" RELATED [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" RELATED [EC:2.1.1.59]
xref: EC:2.1.1.59
xref: MetaCyc:2.1.1.59-RXN
xref: RHEA:24312
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity

[Term]
id: GO:0000278
name: mitotic cell cycle
namespace: biological_process
alt_id: GO:0007067
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_yeast
synonym: "mitosis" RELATED []
xref: Wikipedia:Mitosis
is_a: GO:0007049 ! cell cycle

[Term]
id: GO:0000279
name: M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M-phase" EXACT []
xref: Wikipedia:M_phase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0000280
name: nuclear division
namespace: biological_process
def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000281
name: mitotic cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
subset: goslim_pombe
synonym: "cytokinesis after mitosis" EXACT []
is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:0000282
name: cellular bud site selection
namespace: biological_process
def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah]
comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010).
synonym: "bud site selection/establishment of cell polarity" BROAD []
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:0000284
name: obsolete shmoo orientation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable.
synonym: "shmoo orientation" EXACT []
is_obsolete: true
replaced_by: GO:0000753

[Term]
id: GO:0000285
name: 1-phosphatidylinositol-3-phosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+." [EC:2.7.1.150, RHEA:13609]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.150]
synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" RELATED [EC:2.7.1.150]
synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT []
synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150]
xref: EC:2.7.1.150
xref: KEGG_REACTION:R05802
xref: MetaCyc:2.7.1.150-RXN
xref: Reactome:R-HSA-1675910 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane"
xref: Reactome:R-HSA-1675921 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane"
xref: Reactome:R-HSA-1676134 "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane"
xref: Reactome:R-HSA-1676168 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane"
xref: RHEA:13609
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0000286
name: alanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1]
synonym: "AlaDH" RELATED [EC:1.4.1.1]
synonym: "alanine oxidoreductase activity" RELATED [EC:1.4.1.1]
synonym: "alpha-alanine dehydrogenase activity" RELATED [EC:1.4.1.1]
synonym: "L-alanine dehydrogenase activity" RELATED [EC:1.4.1.1]
synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.1]
synonym: "NAD-dependent alanine dehydrogenase activity" RELATED [EC:1.4.1.1]
synonym: "NAD-linked alanine dehydrogenase activity" RELATED [EC:1.4.1.1]
synonym: "NADH-dependent alanine dehydrogenase activity" RELATED [EC:1.4.1.1]
xref: EC:1.4.1.1
xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN
xref: RHEA:18405
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0000287
name: magnesium ion binding
namespace: molecular_function
def: "Binding to a magnesium (Mg) ion." [GOC:ai]
synonym: "magnesium binding" EXACT []
synonym: "Mg binding" EXACT []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0000288
name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]
synonym: "deadenylation-dependent mRNA decay" EXACT []
synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT []
synonym: "mRNA catabolic process, deadenylation-dependent" EXACT []
synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylylation-dependent" EXACT []
synonym: "mRNA degradation, deadenylation-dependent decay" EXACT []
synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0061157 ! mRNA destabilization

[Term]
id: GO:0000289
name: nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
synonym: "3' to 5' mRNA deadenylation" RELATED []
synonym: "mRNA deadenylation" RELATED []
synonym: "nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000290
name: deadenylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]
synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT []
synonym: "deadenylylation-dependent decapping" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0110156 ! mRNA methylguanosine-cap decapping
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000291
name: obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]
comment: The reason for obsoletion is that this represents an unnecessary grouping term
synonym: "exonucleolytic degradation of mRNA" EXACT []
synonym: "mRNA breakdown, exonucleolytic" EXACT []
synonym: "mRNA degradation, exonucleolytic" EXACT []
synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT []
is_obsolete: true
replaced_by: GO:0000956

[Term]
id: GO:0000292
name: RNA fragment catabolic process
namespace: biological_process
alt_id: GO:0030452
def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah]
synonym: "group I intron catabolic process" NARROW []
synonym: "RNA fragment breakdown" EXACT []
synonym: "RNA fragment catabolism" EXACT [GOC:mah]
synonym: "RNA fragment degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0000293
name: ferric-chelate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe2+-siderophore + electron acceptor." [PMID:33559753]
synonym: "ferric chelate reductase activity" EXACT []
synonym: "iron chelate reductase activity" EXACT []
is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions

[Term]
id: GO:0000294
name: nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
namespace: biological_process
def: "A minor MRP-dependent nuclear-transcribed mRNA degradation pathway that begins with an endonucleolytic cleavage to generate unprotected ends." [PMID:14729943]
synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT []
synonym: "nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay" RELATED []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000295
name: adenine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870]
xref: Reactome:R-HSA-389652 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP"
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity

[Term]
id: GO:0000296
name: spermine transport
namespace: biological_process
def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0000297
name: spermine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai]
is_a: GO:0015203 ! polyamine transmembrane transporter activity

[Term]
id: GO:0000298
name: endopolyphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10]
synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polymetaphosphatase activity" RELATED [EC:3.6.1.10]
synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate polyphosphohydrolase activity" RELATED [EC:3.6.1.10]
xref: EC:3.6.1.10
xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN
xref: RHEA:22452
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000299
name: obsolete integral to membrane of membrane fraction
namespace: cellular_component
def: "OBSOLETE. Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "integral to membrane of membrane fraction" EXACT []
is_obsolete: true

[Term]
id: GO:0000300
name: obsolete peripheral to membrane of membrane fraction
namespace: cellular_component
def: "OBSOLETE. Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "peripheral to membrane of membrane fraction" EXACT []
is_obsolete: true
consider: GO:0019898

[Term]
id: GO:0000301
name: retrograde transport, vesicle recycling within Golgi
namespace: biological_process
def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]
synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0000302
name: response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
synonym: "response to active oxygen species" EXACT []
synonym: "response to AOS" EXACT []
synonym: "response to reactive oxidative species" EXACT []
synonym: "response to reactive oxygen intermediate" EXACT []
synonym: "response to ROI" EXACT []
synonym: "response to ROS" EXACT []
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0000303
name: response to superoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732]
is_a: GO:0000305 ! response to oxygen radical

[Term]
id: GO:0000304
name: response to singlet oxygen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732]
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0000305
name: response to oxygen radical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653]
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0000306
name: obsolete extrinsic component of vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "extrinsic to vacuolar membrane" EXACT []
is_obsolete: true
consider: GO:0005774

[Term]
id: GO:0000307
name: cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]
subset: goslim_pir
synonym: "CDK holoenzyme" EXACT []
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0000308
name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc]
synonym: "CDK holoenzyme" BROAD []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000309
name: nicotinamide-nucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1]
synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" RELATED [EC:2.7.7.1]
synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT []
synonym: "ATP:NMN adenylyltransferase activity" RELATED [EC:2.7.7.1]
synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1]
synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD+ diphosphorylase activity" RELATED [EC:2.7.7.1]
synonym: "NAD+ pyrophosphorylase activity" RELATED [EC:2.7.7.1]
synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMNAT activity" NARROW [EC:2.7.7.1]
xref: EC:2.7.7.1
xref: MetaCyc:2.7.7.1-RXN
xref: Reactome:R-HSA-8939959 "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+"
xref: RHEA:21360
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0000310
name: xanthine phosphoribosyltransferase activity
namespace: molecular_function
alt_id: GO:0009043
def: "Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine." [RHEA:10800]
synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.22]
synonym: "Xan phosphoribosyltransferase activity" RELATED [EC:2.4.2.22]
synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT []
synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.22]
synonym: "xanthylate pyrophosphorylase activity" RELATED [EC:2.4.2.22]
synonym: "xanthylic pyrophosphorylase activity" RELATED [EC:2.4.2.22]
synonym: "XMP pyrophosphorylase activity" RELATED [EC:2.4.2.22]
synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.22]
xref: EC:2.4.2.22
xref: MetaCyc:XANPRIBOSYLTRAN-RXN
xref: RHEA:10800
is_a: GO:0106130 ! purine phosphoribosyltransferase activity

[Term]
id: GO:0000311
name: plastid large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0000315 ! organellar large ribosomal subunit
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000312
name: plastid small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc]
is_a: GO:0000314 ! organellar small ribosomal subunit
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000313
name: organellar ribosome
namespace: cellular_component
def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc]
is_a: GO:0005840 ! ribosome
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0000314
name: organellar small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc]
is_a: GO:0015935 ! small ribosomal subunit
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000315
name: organellar large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0015934 ! large ribosomal subunit
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000316
name: sulfite transmembrane transport
namespace: biological_process
def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "sulphite transport" EXACT []
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:0000319
name: sulfite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfite ions from one side of a membrane to the other." [GOC:as]
synonym: "sulphite transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0000320
name: re-entry into mitotic cell cycle
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0000321
name: re-entry into mitotic cell cycle after pheromone arrest
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449]
is_a: GO:0000320 ! re-entry into mitotic cell cycle
is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000322
name: storage vacuole
namespace: cellular_component
def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000323
name: lytic vacuole
namespace: cellular_component
def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000324
name: fungal-type vacuole
namespace: cellular_component
def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649]
synonym: "vacuole, cell cycle-correlated morphology" EXACT []
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0000325
name: plant-type vacuole
namespace: cellular_component
def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208]
synonym: "vacuole, cell cycle-independent morphology" EXACT []
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000326
name: protein storage vacuole
namespace: cellular_component
def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409]
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000327
name: lytic vacuole within protein storage vacuole
namespace: cellular_component
def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490]
is_a: GO:0000323 ! lytic vacuole
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0000328
name: fungal-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000329
name: fungal-type vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "fungal-type vacuolar membrane" RELATED []
synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0098852 ! lytic vacuole membrane
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000330
name: plant-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000331
name: contractile vacuole
namespace: cellular_component
def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory." [GOC:jl, PMID:10503189, PMID:23890380]
synonym: "central bladder" RELATED [PMID:23890380]
synonym: "central vacuole" RELATED [PMID:23890380]
xref: Wikipedia:Contractile_vacuole
is_a: GO:0005773 ! vacuole
is_a: GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0062159 ! contractile vacuole complex

[Term]
id: GO:0000332
name: template for synthesis of G-rich strand of telomere DNA activity
namespace: molecular_function
def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242, PMID:7958872]
comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins.
synonym: "telomerase RNA" EXACT []
synonym: "telomerase, template" EXACT []
is_a: GO:0000497 ! DNA template activity
relationship: part_of GO:0003720 ! telomerase activity

[Term]
id: GO:0000333
name: telomerase catalytic core complex
namespace: cellular_component
def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [GOC:BHF-UCL, PMID:11884619, PMID:1808260]
synonym: "TERT-TERC complex" RELATED [GOC:nc, PMID:19701182]
is_a: GO:0005697 ! telomerase holoenzyme complex
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0000334
name: 3-hydroxyanthranilate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+." [EC:1.13.11.6, RHEA:17953]
synonym: "3-hydroxyanthranilate oxygenase activity" RELATED [EC:1.13.11.6]
synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid dioxygenase activity" RELATED [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid oxygenase activity" RELATED [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic oxygenase activity" RELATED [EC:1.13.11.6]
synonym: "3HAO" RELATED [EC:1.13.11.6]
xref: EC:1.13.11.6
xref: KEGG_REACTION:R02665
xref: MetaCyc:1.13.11.6-RXN
xref: Reactome:R-HSA-71218 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde"
xref: RHEA:17953
xref: UM-BBD_reactionID:r1027
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0000335
name: obsolete negative regulation of transposition, DNA-mediated
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "down regulation of DNA transposition" EXACT []
synonym: "down-regulation of DNA transposition" EXACT []
synonym: "downregulation of DNA transposition" EXACT []
synonym: "inhibition of DNA transposition" NARROW []
synonym: "negative regulation of DNA transposition" EXACT [GOC:dph]
is_obsolete: true
consider: GO:0006313

[Term]
id: GO:0000336
name: obsolete positive regulation of transposition, DNA-mediated
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation of DNA transposition" NARROW []
synonym: "positive regulation of DNA transposition" EXACT [GOC:dph]
synonym: "stimulation of DNA transposition" NARROW []
synonym: "up regulation of DNA transposition" EXACT []
synonym: "up-regulation of DNA transposition" EXACT []
synonym: "upregulation of DNA transposition" EXACT []
is_obsolete: true
consider: GO:0006313

[Term]
id: GO:0000337
name: obsolete regulation of transposition, DNA-mediated
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of DNA transposition" EXACT [GOC:dph]
is_obsolete: true
consider: GO:0006313

[Term]
id: GO:0000338
name: protein deneddylation
namespace: biological_process
alt_id: GO:0010388
def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
synonym: "cullin deneddylation" NARROW []
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0000339
name: RNA cap binding
namespace: molecular_function
def: "Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc]
synonym: "binding to mRNA cap" NARROW []
synonym: "mRNA cap binding" NARROW []
synonym: "snRNA cap binding" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000340
name: RNA 7-methylguanosine cap binding
namespace: molecular_function
def: "Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]
synonym: "RNA m7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000341
name: RNA trimethylguanosine cap binding
namespace: molecular_function
def: "Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc]
synonym: "RNA m2,2,7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000342
name: RNA cap 4 binding
namespace: molecular_function
def: "Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975]
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000343
name: plastid-encoded plastid RNA polymerase complex A
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105]
synonym: "PEP-A" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000344
name: plastid-encoded plastid RNA polymerase complex B
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105]
synonym: "PEP-B" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000345
name: cytosolic DNA-directed RNA polymerase complex
namespace: cellular_component
def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0000346
name: transcription export complex
namespace: cellular_component
def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277]
subset: goslim_pir
synonym: "TREX complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0000347
name: THO complex
namespace: cellular_component
def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
subset: goslim_pir
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0000348
name: mRNA branch site recognition
namespace: biological_process
alt_id: GO:0000370
alt_id: GO:0000371
def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian).
synonym: "nuclear mRNA branch site recognition" EXACT [GOC:vw]
synonym: "spliceosomal A complex biosynthesis" NARROW []
synonym: "spliceosomal A complex formation" NARROW []
synonym: "spliceosomal B complex biosynthesis" NARROW []
synonym: "spliceosomal B complex formation" NARROW []
synonym: "U12-type nuclear mRNA branch site recognition" NARROW []
synonym: "U2-type nuclear mRNA branch site recognition" NARROW []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly

[Term]
id: GO:0000349
name: generation of catalytic spliceosome for first transesterification step
namespace: biological_process
alt_id: GO:0000356
alt_id: GO:0000357
def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian).
synonym: "catalytic spliceosome assembly for first transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for first transesterification step" EXACT []
synonym: "spliceosomal A2-2 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-2 complex formation" NARROW []
synonym: "spliceosomal C1 complex biosynthesis" NARROW []
synonym: "spliceosomal C1 complex formation" NARROW []
synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW []
synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000350
name: generation of catalytic spliceosome for second transesterification step
namespace: biological_process
alt_id: GO:0000358
alt_id: GO:0000359
def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian).
synonym: "catalytic spliceosome assembly for second transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for second transesterification step" EXACT []
synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW []
synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW []
synonym: "formation of spliceosomal A2-2 complex" NARROW []
synonym: "formation of spliceosomal C1 complex" NARROW []
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
synonym: "spliceosomal A2-3 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-3 complex formation" NARROW []
synonym: "spliceosomal C2 complex biosynthesis" NARROW []
synonym: "spliceosomal C2 complex formation" NARROW []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000352
name: trans assembly of SL-containing precatalytic spliceosome
namespace: biological_process
def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly
relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition

[Term]
id: GO:0000353
name: formation of quadruple SL/U4/U5/U6 snRNP
namespace: biological_process
def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897]
comment: Note that this step is analogous to 5' splice site selection in cis-splicing.
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition

[Term]
id: GO:0000354
name: cis assembly of pre-catalytic spliceosome
namespace: biological_process
alt_id: GO:0000360
alt_id: GO:0000361
def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals).
synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW []
synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW []
synonym: "formation of spliceosomal A2-1 complex" NARROW []
synonym: "formation of spliceosomal B1 complex" NARROW []
synonym: "spliceosomal A2-1 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-1 complex formation" NARROW []
synonym: "spliceosomal B1 complex biosynthesis" NARROW []
synonym: "spliceosomal B1 complex formation" NARROW []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly
relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome

[Term]
id: GO:0000362
name: obsolete first U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "first U2-type spliceosomal transesterification activity" EXACT []
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000363
name: obsolete first U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "first U12-type spliceosomal transesterification activity" EXACT []
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000364
name: obsolete second U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "second U2-type spliceosomal transesterification activity" EXACT []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000365
name: mRNA trans splicing, via spliceosome
namespace: biological_process
def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897, PMID:18458335]
synonym: "nuclear mRNA trans splicing, via spliceosome" EXACT [GOC:vw]
synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW []
is_a: GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000366
name: mRNA alternative trans-splicing
namespace: biological_process
def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900]
synonym: "intergenic mRNA trans splicing" EXACT []
synonym: "intergenic nuclear mRNA trans splicing" EXACT [GOC:vw]
is_a: GO:0000365 ! mRNA trans splicing, via spliceosome
is_a: GO:0000380 ! alternative mRNA splicing, via spliceosome

[Term]
id: GO:0000367
name: obsolete second U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "second U12-type spliceosomal transesterification activity" EXACT []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000372
name: Group I intron splicing
namespace: biological_process
def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794]
comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone).
synonym: "mRNA splicing" RELATED []
is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile

[Term]
id: GO:0000373
name: Group II intron splicing
namespace: biological_process
def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794]
comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria.
synonym: "mRNA splicing" RELATED []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000374
name: Group III intron splicing
namespace: biological_process
def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794]
comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists.
synonym: "mRNA splicing" RELATED []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000375
name: RNA splicing, via transesterification reactions
namespace: biological_process
alt_id: GO:0000385
alt_id: GO:0031202
def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc]
comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.
subset: goslim_pir
synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah]
synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah]
synonym: "spliceosomal catalysis" RELATED []
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000376
name: RNA splicing, via transesterification reactions with guanosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794]
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000377
name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794]
synonym: "lariat RNA biosynthesis" RELATED []
synonym: "lariat RNA formation" RELATED []
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000378
name: RNA exon ligation
namespace: biological_process
def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897]
comment: Note that this is not a part of spliceosomal RNA splicing.
is_a: GO:0016070 ! RNA metabolic process
relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000379
name: tRNA-type intron splice site recognition and cleavage
namespace: biological_process
def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000380
name: alternative mRNA splicing, via spliceosome
namespace: biological_process
def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]
comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
synonym: "alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "splice site selection" BROAD []
is_a: GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000381
name: regulation of alternative mRNA splicing, via spliceosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
synonym: "regulation of alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "splice site selection" BROAD []
is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome
relationship: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome

[Term]
id: GO:0000384
name: first spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897, PMID:19239890]
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0000386
name: second spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897, PMID:19239890]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
xref: Reactome:R-HSA-9770236 "Formation of the Spliceosomal P complex and exon ligation"
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0000387
name: spliceosomal snRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah]
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000388
name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
namespace: biological_process
alt_id: GO:0000396
alt_id: GO:0000397
def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian).
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "spliceosomal A1 complex biosynthesis" NARROW []
synonym: "spliceosomal A1 complex formation" NARROW []
synonym: "spliceosomal B2 complex biosynthesis" NARROW []
synonym: "spliceosomal B2 complex formation" NARROW []
synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW []
synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000389
name: mRNA 3'-splice site recognition
namespace: biological_process
alt_id: GO:0000382
alt_id: GO:0000383
def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897]
synonym: "nuclear mRNA 3'-splice site recognition" EXACT [GOC:vw]
synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site recognition

[Term]
id: GO:0000390
name: spliceosomal complex disassembly
namespace: biological_process
alt_id: GO:0000391
alt_id: GO:0000392
def: "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897]
synonym: "spliceosome complex disassembly" EXACT []
synonym: "spliceosome disassembly" BROAD []
synonym: "U12-type spliceosome disassembly" NARROW []
synonym: "U2-type spliceosome disassembly" NARROW []
is_a: GO:0032988 ! protein-RNA complex disassembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000393
name: spliceosomal conformational changes to generate catalytic conformation
namespace: biological_process
def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000394
name: RNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897]
comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
synonym: "mRNA splicing" BROAD []
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000395
name: mRNA 5'-splice site recognition
namespace: biological_process
alt_id: GO:0000368
alt_id: GO:0000369
def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian).
synonym: "nuclear mRNA 5' splice site recognition" EXACT []
synonym: "nuclear mRNA 5'-splice site recognition" EXACT [GOC:vw]
synonym: "spliceosomal CC complex biosynthesis" NARROW []
synonym: "spliceosomal CC complex formation" NARROW []
synonym: "spliceosomal commitment complex biosynthesis" NARROW []
synonym: "spliceosomal commitment complex formation" NARROW []
synonym: "spliceosomal E complex biosynthesis" NARROW []
synonym: "spliceosomal E complex formation" NARROW []
synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site recognition
relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome

[Term]
id: GO:0000398
name: mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0006374
alt_id: GO:0006375
def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
synonym: "mRNA splicing" BROAD []
synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW []
synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "nuclear mRNA splicing, via spliceosome" EXACT [GOC:krc, GOC:vw]
synonym: "pre-mRNA splicing" BROAD []
synonym: "splicing AT-AC intron" RELATED []
synonym: "splicing GT-AG intron" RELATED []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0000399
name: cellular bud neck septin structure
namespace: cellular_component
def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005935 ! cellular bud neck
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0000400
name: four-way junction DNA binding
namespace: molecular_function
def: "Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "forked DNA binding" BROAD []
synonym: "Holliday junction binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000401
name: open form four-way junction DNA binding
namespace: molecular_function
def: "Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "open form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000402
name: crossed form four-way junction DNA binding
namespace: molecular_function
def: "Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "crossed form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000403
name: Y-form DNA binding
namespace: molecular_function
def: "Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730]
synonym: "forked DNA binding" BROAD []
synonym: "splayed Y-form DNA binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000404
name: heteroduplex DNA loop binding
namespace: molecular_function
def: "Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730]
synonym: "loop DNA binding" RELATED [GOC:jh]
is_a: GO:0000217 ! DNA secondary structure binding
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0000405
name: bubble DNA binding
namespace: molecular_function
def: "Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, GOC:vw, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000406
name: double-strand/single-strand DNA junction binding
namespace: molecular_function
def: "Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000407
name: phagophore assembly site
namespace: cellular_component
def: "Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
synonym: "PAS" EXACT []
synonym: "perivacuolar space" NARROW []
synonym: "pre-autophagosomal structure" NARROW []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000408
name: EKC/KEOPS complex
namespace: cellular_component
def: "A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, GOC:vw, PMID:16564010, PMID:16874308, PMID:21183954, PMID:23945934]
comment: Originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation.
synonym: "endopeptidase-like kinase chromatin-associated protein complex" EXACT []
synonym: "KEOPS/EKC complex" EXACT [PMID:21183954, PMID:23945934]
synonym: "kinase, putative endopeptidase and other proteins of small size protein complex" EXACT []
synonym: "TCTC" RELATED [PMID:25629598]
synonym: "threonyl-carbamoly transferase complex" RELATED [PMID:25629598]
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0000409
name: regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]
is_a: GO:0006355 ! regulation of DNA-templated transcription

[Term]
id: GO:0000410
name: carbon catabolite repression of transcription by galactose
namespace: biological_process
def: "A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah]
synonym: "down regulation of transcription by galactose" EXACT []
synonym: "down-regulation of transcription by galactose" EXACT []
synonym: "downregulation of transcription by galactose" EXACT []
synonym: "inhibition of transcription by galactose" NARROW []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045013 ! carbon catabolite repression of transcription

[Term]
id: GO:0000411
name: positive regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators]
synonym: "activation of transcription by galactose" NARROW []
synonym: "stimulation of transcription by galactose" NARROW []
synonym: "up regulation of transcription by galactose" EXACT []
synonym: "up-regulation of transcription by galactose" EXACT []
synonym: "upregulation of transcription by galactose" EXACT []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045991 ! carbon catabolite activation of transcription

[Term]
id: GO:0000412
name: obsolete histone peptidyl-prolyl isomerization
namespace: biological_process
def: "OBSOLETE. The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone proline isomerization" EXACT []
is_obsolete: true

[Term]
id: GO:0000413
name: protein peptidyl-prolyl isomerization
namespace: biological_process
def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
subset: gocheck_obsoletion_candidate
synonym: "protein proline isomerization" EXACT []
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0000414
name: obsolete regulation of histone H3-K36 methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0140673

[Term]
id: GO:0000415
name: obsolete negative regulation of histone H3-K36 methylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3-K36 methylation" EXACT []
synonym: "down-regulation of histone H3-K36 methylation" EXACT []
synonym: "downregulation of histone H3-K36 methylation" EXACT []
synonym: "inhibition of histone H3-K36 methylation" NARROW []
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:0000416
name: obsolete positive regulation of histone H3-K36 methylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3-K36 methylation" NARROW []
synonym: "stimulation of histone H3-K36 methylation" NARROW []
synonym: "up regulation of histone H3-K36 methylation" EXACT []
synonym: "up-regulation of histone H3-K36 methylation" EXACT []
synonym: "upregulation of histone H3-K36 methylation" EXACT []
is_obsolete: true
consider: GO:0046975

[Term]
id: GO:0000417
name: HIR complex
namespace: cellular_component
def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700]
synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0000418
name: RNA polymerase IV complex
namespace: cellular_component
alt_id: GO:0000420
def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459]
synonym: "DNA-directed RNA polymerase IV complex" EXACT []
synonym: "DNA-directed RNA polymerase IVa complex" EXACT []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0000419
name: RNA polymerase V complex
namespace: cellular_component
alt_id: GO:0080137
def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459]
synonym: "DNA-directed RNA polymerase IVb complex" EXACT []
synonym: "DNA-directed RNA polymerase V complex" EXACT []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0000421
name: autophagosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]
synonym: "autophagic vacuole membrane" EXACT [GOC:autophagy]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005776 ! autophagosome

[Term]
id: GO:0000422
name: autophagy of mitochondrion
namespace: biological_process
def: "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]
synonym: "mitochondrion degradation" BROAD []
synonym: "mitochondrion disassembly" BROAD []
synonym: "mitophagy" NARROW []
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0000423
name: mitophagy
namespace: biological_process
def: "The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367]
comment: Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes.
synonym: "macromitophagy" EXACT []
xref: Wikipedia:Mitophagy
is_a: GO:0000422 ! autophagy of mitochondrion
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0000424
name: micromitophagy
namespace: biological_process
def: "Degradation of a mitochondrion by microautophagy." [PMID:15798367, PMID:27003723]
comment: Note that this term is not a child of mitophagy because the community generally uses the latter to refer to the macroautophagy of mitochondria.
is_a: GO:0000422 ! autophagy of mitochondrion
is_a: GO:0016237 ! microautophagy

[Term]
id: GO:0000425
name: pexophagy
namespace: biological_process
def: "The selective autophagy process in which a peroxisome is degraded by macroautophagy." [GOC:autophagy, PMID:12914914, PMID:16973210]
synonym: "macropexophagy" EXACT []
is_a: GO:0016236 ! macroautophagy
is_a: GO:0030242 ! autophagy of peroxisome

[Term]
id: GO:0000426
name: micropexophagy
namespace: biological_process
def: "Degradation of a peroxisome by microautophagy." [GOC:autophagy, GOC:pad, PMID:12914914, PMID:15350980, PMID:16973210]
comment: Note that this term is not a child of pexophagy because the community usually uses the latter to refer to the macroautohagy process.
is_a: GO:0016237 ! microautophagy
is_a: GO:0030242 ! autophagy of peroxisome

[Term]
id: GO:0000427
name: plastid-encoded plastid RNA polymerase complex
namespace: cellular_component
def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0000428
name: DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0000429
name: carbon catabolite regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II
is_a: GO:0045990 ! carbon catabolite regulation of transcription

[Term]
id: GO:0000430
name: regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0000431
name: regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0000432
name: positive regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter
is_a: GO:0046016 ! positive regulation of transcription by glucose

[Term]
id: GO:0000433
name: carbon catabolite repression of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW []
is_a: GO:0045014 ! carbon catabolite repression of transcription by glucose
is_a: GO:0061987 ! negative regulation of transcription from RNA polymerase II promoter by glucose

[Term]
id: GO:0000434
name: carbon catabolite repression of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW []
is_a: GO:0000410 ! carbon catabolite repression of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter

[Term]
id: GO:0000435
name: positive regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
is_a: GO:0000411 ! positive regulation of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter

[Term]
id: GO:0000436
name: carbon catabolite activation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II
is_a: GO:0045991 ! carbon catabolite activation of transcription

[Term]
id: GO:0000437
name: carbon catabolite repression of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc]
synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0045013 ! carbon catabolite repression of transcription

[Term]
id: GO:0000438
name: core TFIIH complex portion of holo TFIIH complex
namespace: cellular_component
alt_id: GO:0000443
def: "The core TFIIH complex when it is part of the general transcription factor TFIIH." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
synonym: "SSL2-core TFIIH complex portion of holo TFIIH complex" EXACT []
is_a: GO:0000439 ! transcription factor TFIIH core complex
relationship: part_of GO:0005675 ! transcription factor TFIIH holo complex

[Term]
id: GO:0000439
name: transcription factor TFIIH core complex
namespace: cellular_component
alt_id: GO:0000441
def: "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
subset: goslim_pir
synonym: "core TFIIH complex" EXACT []
synonym: "SSL2-core TFIIH complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0000440
name: core TFIIH complex portion of NEF3 complex
namespace: cellular_component
alt_id: GO:0000442
def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3)." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
synonym: "SSL2-core TFIIH complex portion of NEF3 complex" EXACT []
is_a: GO:0000439 ! transcription factor TFIIH core complex
relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex

[Term]
id: GO:0000444
name: MIS12/MIND type complex
namespace: cellular_component
alt_id: GO:0000818
def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270]
synonym: "MIND complex" EXACT []
synonym: "Mis12 complex" NARROW []
synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" RELATED []
synonym: "nuclear MIS12/MIND complex" RELATED []
is_a: GO:0000940 ! outer kinetochore

[Term]
id: GO:0000445
name: THO complex part of transcription export complex
namespace: cellular_component
def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
synonym: "THO complex part of TREX complex" EXACT []
is_a: GO:0000347 ! THO complex
relationship: part_of GO:0000346 ! transcription export complex

[Term]
id: GO:0000446
name: nucleoplasmic THO complex
namespace: cellular_component
def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, GOC:se, PMID:11060033, PMID:11979277, PMID:16983072]
is_a: GO:0000347 ! THO complex
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0000447
name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A2" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000448
name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
alt_id: GO:0000490
def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "cleavage at C2" RELATED []
synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000449
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000450
name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000451
name: rRNA 2'-O-methylation
namespace: biological_process
def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0000452
name: snoRNA guided rRNA 2'-O-methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337]
synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000451 ! rRNA 2'-O-methylation

[Term]
id: GO:0000453
name: obsolete enzyme-directed rRNA 2'-O-methylation
namespace: biological_process
def: "OBSOLETE. The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006364

[Term]
id: GO:0000454
name: snoRNA guided rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337]
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000455
name: enzyme-directed rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337]
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000456
name: obsolete dimethylation involved in SSU-rRNA maturation
namespace: biological_process
def: "OBSOLETE. Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337]
comment: The reason for obsoletion is that this term can be captured as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0000457
name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000458
name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000459
name: obsolete exonucleolytic trimming involved in rRNA processing
namespace: biological_process
def: "OBSOLETE. Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0006364

[Term]
id: GO:0000460
name: maturation of 5.8S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000461
name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at site D" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000462
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
alt_id: GO:1990041
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
synonym: "maturation of 18S rRNA" NARROW []
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000463
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000464
name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at A3" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000465
name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000466
name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000467
name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000468
name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
synonym: "processing at B2" NARROW []
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000469
name: obsolete cleavage involved in rRNA processing
namespace: biological_process
def: "OBSOLETE. Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0006364

[Term]
id: GO:0000470
name: maturation of LSU-rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing
relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis

[Term]
id: GO:0000471
name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410]
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000472
name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A1" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000473
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000474
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000475
name: maturation of 2S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000476
name: maturation of 4.5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000477
name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "processing at C1" NARROW []
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000478
name: obsolete endonucleolytic cleavage involved in rRNA processing
namespace: biological_process
def: "OBSOLETE. Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0000479
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000480
name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326]
synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326]
synonym: "endonucleolytic cleavage at A0" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000481
name: maturation of 5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000482
name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000481 ! maturation of 5S rRNA

[Term]
id: GO:0000483
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000484
name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000485
name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA

[Term]
id: GO:0000486
name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000487
name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000488
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000489
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000491
name: small nucleolar ribonucleoprotein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "snoRNP assembly" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly

[Term]
id: GO:0000492
name: box C/D snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000493
name: box H/ACA snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383]
synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000494
name: box C/D sno(s)RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box C/D RNA molecule." [GOC:krc]
synonym: "box C/D RNA 3' end processing" EXACT []
synonym: "box C/D snoRNA 3'-end processing" NARROW []
synonym: "box C/D sRNA 3'-end processing" NARROW []
is_a: GO:0031126 ! sno(s)RNA 3'-end processing
is_a: GO:0034963 ! box C/D sno(s)RNA processing

[Term]
id: GO:0000495
name: box H/ACA sno(s)RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box H/ACA RNA molecule." [GOC:krc]
synonym: "box H/ACA RNA 3' end processing" EXACT []
synonym: "box H/ACA snoRNA 3'-end processing" NARROW []
synonym: "box H/ACA sRNA 3'-end processing" NARROW []
is_a: GO:0031126 ! sno(s)RNA 3'-end processing
is_a: GO:0034964 ! box H/ACA sno(s)RNA processing

[Term]
id: GO:0000497
name: DNA template activity
namespace: molecular_function
def: "Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
synonym: "base pairing with DNA" RELATED []
is_a: GO:0003677 ! DNA binding
is_a: GO:0140489 ! molecular template activity

[Term]
id: GO:0000500
name: RNA polymerase I upstream activating factor complex
namespace: cellular_component
def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378]
synonym: "RNA polymerase I upstream activation factor complex" EXACT []
synonym: "UAF" EXACT []
is_a: GO:0000120 ! RNA polymerase I transcription regulator complex

[Term]
id: GO:0000502
name: proteasome complex
namespace: cellular_component
def: "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome]
subset: goslim_pir
synonym: "26S proteasome" NARROW []
synonym: "proteasome" EXACT [GOC:cjm]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1905369 ! endopeptidase complex

[Term]
id: GO:0000504
name: obsolete proteasome regulatory particle (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb]
comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase.
synonym: "26S proteasome" NARROW []
synonym: "proteasome regulatory particle (sensu Bacteria)" EXACT []
is_obsolete: true

[Term]
id: GO:0000506
name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411]
comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity.
synonym: "GPI-GlcNAc transferase complex" EXACT []
synonym: "GPI-GnT complex" EXACT []
synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0000510
name: H3-H4 histone complex chaperone activity
namespace: molecular_function
def: "A histone chaperone that carries a H3-H4 histone complex." [PMID:28053344]
comment: Mammalian cells have seven known sequence variants of histone H3. These are denoted as Histone H3.1, Histone H3.2, Histone H3.3, Histone H3.4 (H3T), Histone H3.5, Histone H3.X and Histone H3.Y (https://en.wikipedia.org/wiki/Histone_H3).
synonym: "H3-H4 histone carrier activity" EXACT []
synonym: "H3.1-H4 histone complex chaperone activity" NARROW []
synonym: "H3.2-H4 histone complex chaperone activity" NARROW []
synonym: "H3.3-H4 histone complex chaperone activity" NARROW []
is_a: GO:0140713 ! histone chaperone activity

[Term]
id: GO:0000511
name: H2A-H2B histone complex chaperone activity
namespace: molecular_function
def: "A histone chaperone that carries a H2A-H2B histone complex." [PMID:28053344]
synonym: "H2A-H2B histone carrier activity" EXACT []
is_a: GO:0140713 ! histone chaperone activity

[Term]
id: GO:0000512
name: lncRNA-mediated post-transcriptional gene silencing
namespace: biological_process
def: "A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs or mRNAs." [PMID:34454184, PMID:35055152]
comment: This term should be applied to lncRNAs and proteins associated with this process and not to the target (miRNAs or mRNAs) of the process.
synonym: "lncRNA-mediated gene silencing" BROAD []
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0000513
name: actin severing activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a actin severing protein." [PMID:25451933]
is_a: GO:0140677 ! molecular function activator activity

[Term]
id: GO:0000514
name: 3-sulfino-L-alanine: proton, glutamate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out)." [PMID:11566871, RHEA:70967]
xref: RHEA:70967
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0000515
name: aspartate:glutamate, proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in)." [PMID:11566871, RHEA:70783]
xref: RHEA:70783
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0000578
name: embryonic axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
synonym: "embryonic axis determination" RELATED []
is_a: GO:0009798 ! axis specification
is_a: GO:0009880 ! embryonic pattern specification

[Term]
id: GO:0000700
name: mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000701
name: purine-specific mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623]
synonym: "A/G-specific adenine DNA glycosylase activity" NARROW []
xref: EC:3.2.2.31
is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0000702
name: oxidized base lesion DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000703
name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0019004
def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
synonym: "bifunctional DNA glycosylase" BROAD []
synonym: "DNA glycosylase/AP-lyase" BROAD []
synonym: "DNA glycosylase/beta-lyase" BROAD []
synonym: "endodeoxyribonuclease III" RELATED []
synonym: "endonuclease III" RELATED []
synonym: "endonuclease VIII activity" RELATED []
synonym: "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT [GOC:go_curators]
synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: Reactome:R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase"
xref: Reactome:R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase"
xref: Reactome:R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity

[Term]
id: GO:0000704
name: pyrimidine dimer DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000705
name: achiasmate meiosis I
namespace: biological_process
def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419]
synonym: "achiasmate meiosis I nuclear division" EXACT []
is_a: GO:0007127 ! meiosis I

[Term]
id: GO:0000706
name: meiotic DNA double-strand break processing
namespace: biological_process
def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]
is_a: GO:0000729 ! DNA double-strand break processing
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0000707
name: meiotic DNA recombinase assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983]
is_a: GO:0000730 ! DNA recombinase assembly
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0000708
name: meiotic strand invasion
namespace: biological_process
def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877]
synonym: "meiotic D-loop biosynthesis" RELATED []
synonym: "meiotic D-loop formation" RELATED []
synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw]
is_a: GO:0042148 ! DNA strand invasion
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0000709
name: meiotic joint molecule formation
namespace: biological_process
def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495]
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0000710
name: meiotic mismatch repair
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855]
is_a: GO:0006298 ! mismatch repair
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0000711
name: meiotic DNA repair synthesis
namespace: biological_process
def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0000712
name: resolution of meiotic recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah]
is_a: GO:0061982 ! meiosis I cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0000713
name: meiotic heteroduplex formation
namespace: biological_process
def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324]
is_a: GO:0061982 ! meiosis I cell cycle process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0000714
name: meiotic strand displacement
namespace: biological_process
def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855]
synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw]
is_a: GO:0000732 ! DNA strand displacement
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0000715
name: nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977]
synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED []
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000716
name: transcription-coupled nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977]
synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED []
is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition
relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair

[Term]
id: GO:0000717
name: nucleotide-excision repair, DNA duplex unwinding
namespace: biological_process
def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977]
is_a: GO:0032508 ! DNA duplex unwinding
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000718
name: nucleotide-excision repair, DNA damage removal
namespace: biological_process
def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977]
is_a: GO:0044349 ! DNA excision
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000719
name: photoreactive repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863]
synonym: "pyrimidine-dimer repair by photolyase" NARROW []
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000720
name: pyrimidine dimer repair by nucleotide-excision repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh]
comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'.
is_a: GO:0006289 ! nucleotide-excision repair
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000721
name: (R,R)-butanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+." [EC:1.1.1.4]
synonym: "(R)-2,3-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "(R)-diacetyl reductase activity" RELATED [EC:1.1.1.4]
synonym: "1-amino-2-propanol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "1-amino-2-propanol oxidoreductase activity" RELATED [EC:1.1.1.4]
synonym: "2,3-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "aminopropanol oxidoreductase activity" RELATED [EC:1.1.1.4]
synonym: "butylene glycol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "butyleneglycol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "D-(-)-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" RELATED [EC:1.1.1.4]
synonym: "D-aminopropanol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "D-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4]
synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4]
xref: EC:1.1.1.4
xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN
xref: RHEA:24340
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000722
name: telomere maintenance via recombination
namespace: biological_process
def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777]
synonym: "telomerase-independent telomere maintenance" RELATED []
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0006312 ! mitotic recombination

[Term]
id: GO:0000723
name: telomere maintenance
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]
synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0032200 ! telomere organization

[Term]
id: GO:0000724
name: double-strand break repair via homologous recombination
namespace: biological_process
alt_id: GO:0016924
def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
synonym: "HDR" EXACT [GOC:vk]
synonym: "homologous recombinational repair" EXACT []
synonym: "homology-directed repair" EXACT [GOC:vk]
synonym: "HRR" EXACT []
synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah]
synonym: "Rhp51-dependent recombinational repair" EXACT []
is_a: GO:0000725 ! recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0000725
name: recombinational repair
namespace: biological_process
def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]
xref: Wikipedia:Recombinational_repair
is_a: GO:0006281 ! DNA repair
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0000726
name: obsolete non-recombinational repair
namespace: biological_process
def: "OBSOLETE. A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]
comment: This term was obsoleted because it was defined negatively, and it represents an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0000727
name: double-strand break repair via break-induced replication
namespace: biological_process
def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0000729
name: DNA double-strand break processing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006302 ! double-strand break repair

[Term]
id: GO:0000730
name: DNA recombinase assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855]
synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw]
is_a: GO:0065004 ! protein-DNA complex assembly
is_a: GO:0090735 ! DNA repair complex assembly
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0000731
name: DNA synthesis involved in DNA repair
namespace: biological_process
def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855]
synonym: "DNA repair synthesis" BROAD []
synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb]
synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah]
is_a: GO:0071897 ! DNA biosynthetic process
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0000732
name: DNA strand displacement
namespace: biological_process
def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855]
synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw]
synonym: "strand displacement" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0000733
name: obsolete DNA strand renaturation
namespace: biological_process
def: "OBSOLETE. The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0036310

[Term]
id: GO:0000735
name: removal of nonhomologous ends
namespace: biological_process
def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0000736
name: double-strand break repair via single-strand annealing, removal of nonhomologous ends
namespace: biological_process
def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
is_a: GO:0000735 ! removal of nonhomologous ends
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0000737
name: obsolete DNA catabolic process, endonucleolytic
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
comment: The reason is that these terms represent Molecular functions in the Biological Process ontology.
synonym: "DNA breakdown, endonucleolytic" EXACT []
synonym: "DNA degradation, endonucleolytic" EXACT []
synonym: "endonucleolytic degradation of DNA" EXACT []
synonym: "endonucleolytic DNA catabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006308

[Term]
id: GO:0000738
name: obsolete DNA catabolic process, exonucleolytic
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
comment: The reason is that these terms represent Molecular functions in the Biological Process ontology.
synonym: "DNA breakdown, exonucleolytic" EXACT []
synonym: "DNA degradation, exonucleolytic" EXACT []
synonym: "exonucleolytic degradation of DNA" EXACT []
is_obsolete: true
replaced_by: GO:0006308

[Term]
id: GO:0000739
name: obsolete DNA strand annealing activity
namespace: molecular_function
def: "OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh]
comment: This term was made obsolete because it describes a process and not an activity.
synonym: "DNA strand annealing activity" EXACT []
is_obsolete: true
consider: GO:0036292
consider: GO:0036310

[Term]
id: GO:0000740
name: nuclear membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh]
is_a: GO:0071763 ! nuclear membrane organization
is_a: GO:0090174 ! organelle membrane fusion

[Term]
id: GO:0000741
name: karyogamy
namespace: biological_process
alt_id: GO:0007335
def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh]
synonym: "nuclear fusion" EXACT []
synonym: "nuclear fusion during karyogamy" EXACT []
xref: Wikipedia:Karyogamy
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048284 ! organelle fusion

[Term]
id: GO:0000742
name: karyogamy involved in conjugation with cellular fusion
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh]
synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000741 ! karyogamy
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000743
name: nuclear migration involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0006946
def: "The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt, GOC:vw, PMID:16380440]
synonym: "nuclear congression" EXACT [GOC:vw]
synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030473 ! nuclear migration along microtubule
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000744
name: karyogamy involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena." [GOC:mah, GOC:pg]
synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000741 ! karyogamy
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000745
name: nuclear migration involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah]
synonym: "nuclear exchange during conjugation without cellular fusion" RELATED []
synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000746
name: obsolete conjugation
namespace: biological_process
def: "OBSOLETE. The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh]
comment: This term was obsoleted because it is an unnecessary grouping class.
xref: Wikipedia:Conjugation
is_obsolete: true

[Term]
id: GO:0000747
name: conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007322
alt_id: GO:0007333
alt_id: GO:0030461
alt_id: GO:0030477
def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "cell fusion" RELATED []
synonym: "mating" RELATED []
xref: Wikipedia:Conjugation
is_a: GO:0019953 ! sexual reproduction

[Term]
id: GO:0000748
name: conjugation with mutual genetic exchange
namespace: biological_process
def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh, PMID:22444146]
synonym: "conjugation without cellular fusion" EXACT []
is_a: GO:0019953 ! sexual reproduction

[Term]
id: GO:0000749
name: response to pheromone triggering conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007328
alt_id: GO:0030434
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph]
is_a: GO:0071444 ! cellular response to pheromone
relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000750
name: pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007330
alt_id: GO:0030454
def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
synonym: "transduction of mating signal" BROAD []
is_a: GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion

[Term]
id: GO:0000751
name: mitotic cell cycle G1 arrest in response to pheromone
namespace: biological_process
alt_id: GO:0030571
def: "The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
synonym: "cell cycle arrest in response to pheromone" BROAD []
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion

[Term]
id: GO:0000752
name: agglutination involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007334
def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh]
synonym: "agglutination" BROAD []
synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT []
synonym: "cell-cell adhesion during mating" EXACT []
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms
is_a: GO:0140039 ! cell-cell adhesion in response to extracellular stimulus
relationship: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion

[Term]
id: GO:0000753
name: cell morphogenesis involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007332
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt]
synonym: "shmoo orientation" NARROW []
synonym: "shmooing" NARROW []
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000754
name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007331
alt_id: GO:0030453
def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt]
synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT []
is_a: GO:0023058 ! adaptation of signaling pathway
relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion

[Term]
id: GO:0000755
name: cytogamy
namespace: biological_process
alt_id: GO:0000218
alt_id: GO:0030462
def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
synonym: "zygote formation" RELATED []
is_a: GO:0022413 ! reproductive process in single-celled organism
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000756
name: response to pheromone regulating conjugation with mutual genetic exchange
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion." [GOC:clt]
synonym: "response to pheromone triggering conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007154 ! cell communication
is_a: GO:0071444 ! cellular response to pheromone
relationship: regulates GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000757
name: obsolete signal transduction involved in regulation of conjugation with mutual genetic exchange
namespace: biological_process
def: "OBSOLETE. A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt]
comment: This term was obsoleted because its label and definitions were not clear. It had never been used for annotation.
synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0000758
name: agglutination involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism." [GOC:elh]
synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
synonym: "sexual flocculation" EXACT []
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms
is_a: GO:0140039 ! cell-cell adhesion in response to extracellular stimulus
relationship: part_of GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange

[Term]
id: GO:0000759
name: obsolete cell morphogenesis involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0000760
name: adaptation to pheromone regulating conjugation with mutual genetic exchange
namespace: biological_process
def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT []
is_a: GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange
is_a: GO:0022401 ! negative adaptation of signaling pathway
is_a: GO:2000241 ! regulation of reproductive process

[Term]
id: GO:0000761
name: conjugant formation
namespace: biological_process
def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh]
is_a: GO:0098610 ! adhesion between unicellular organisms
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000762
name: pheromone-induced unidirectional conjugation
namespace: biological_process
def: "Unidirectional transfer of genetic information triggered by to a pheromone signal." [GOC:elh, PMID:17360276, PMID:27021562, PMID:31191478]
is_a: GO:0009291 ! unidirectional conjugation

[Term]
id: GO:0000763
name: obsolete cell morphogenesis involved in unidirectional conjugation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt]
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
synonym: "cell morphogenesis involved in unidirectional conjugation" EXACT []
is_obsolete: true

[Term]
id: GO:0000764
name: obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt]
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb]
synonym: "cellular morphogenesis involved in pheromone-induced unidirectional conjugation" EXACT []
is_obsolete: true

[Term]
id: GO:0000765
name: response to pheromone regulating pheromone-induced unidirectional conjugation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation." [GOC:clt]
synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb]
is_a: GO:0019236 ! response to pheromone
relationship: regulates GO:0000762 ! pheromone-induced unidirectional conjugation

[Term]
id: GO:0000766
name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT []
synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
is_a: GO:0022401 ! negative adaptation of signaling pathway
relationship: part_of GO:0000765 ! response to pheromone regulating pheromone-induced unidirectional conjugation

[Term]
id: GO:0000767
name: obsolete cell morphogenesis involved in conjugation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0000768
name: syncytium formation by plasma membrane fusion
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb]
synonym: "cell fusion" BROAD []
is_a: GO:0006949 ! syncytium formation
is_a: GO:0140253 ! cell-cell fusion

[Term]
id: GO:0000769
name: syncytium formation by mitosis without cytokinesis
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb]
synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah]
is_a: GO:0006949 ! syncytium formation

[Term]
id: GO:0000770
name: peptide pheromone export
namespace: biological_process
alt_id: GO:0007325
def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh]
synonym: "a-factor export" NARROW []
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0000771
name: obsolete agglutination involved in conjugation
namespace: biological_process
def: "OBSOLETE. The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0000772
name: mating pheromone activity
namespace: molecular_function
def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh]
is_a: GO:0005186 ! pheromone activity

[Term]
id: GO:0000773
name: phosphatidyl-N-methylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine. Also catalyzes the transfer of a further methylgroup, producing phosphatidylcholine." [EC:2.1.1.71, PMID:19366698]
synonym: "methyltransferase II" RELATED [EC:2.1.1.71]
synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" RELATED [EC:2.1.1.71]
synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" RELATED [EC:2.1.1.71]
synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71]
synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" RELATED [EC:2.1.1.71]
synonym: "phospholipid methyltransferase activity" RELATED [EC:2.1.1.71]
synonym: "PLMT" EXACT []
synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.71]
xref: EC:2.1.1.71
xref: MetaCyc:2.1.1.71-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000774
name: adenyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd]
xref: Reactome:R-HSA-5252079 "HSP110s exchange ATP for ADP on HSP70s:ADP"
is_a: GO:0060590 ! ATPase regulator activity

[Term]
id: GO:0000775
name: chromosome, centromeric region
namespace: cellular_component
alt_id: GO:0097521
def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'.
synonym: "centromere" RELATED []
synonym: "centromere complex" EXACT []
synonym: "chromosome, centric region" EXACT []
synonym: "chromosome, pericentric region" RELATED []
xref: SO:0000577
is_a: GO:0098687 ! chromosomal region

[Term]
id: GO:0000776
name: kinetochore
namespace: cellular_component
alt_id: GO:0000777
alt_id: GO:0000778
alt_id: GO:0005699
alt_id: GO:0031617
def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore.
subset: goslim_pir
synonym: "condensed chromosome kinetochore" EXACT []
synonym: "condensed nuclear chromosome kinetochore" EXACT []
synonym: "NMS complex" NARROW []
xref: Wikipedia:Kinetochore
is_a: GO:0043232 ! intracellular membraneless organelle
is_a: GO:0099080 ! supramolecular complex
relationship: part_of GO:0000779 ! condensed chromosome, centromeric region

[Term]
id: GO:0000779
name: condensed chromosome, centromeric region
namespace: cellular_component
alt_id: GO:0000780
def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "condensed chromosome, centric region" EXACT []
synonym: "condensed chromosome, centromere" RELATED []
synonym: "condensed chromosome, pericentric region" RELATED []
synonym: "condensed nuclear chromosome, centromeric region" NARROW []
is_a: GO:0000775 ! chromosome, centromeric region
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000781
name: chromosome, telomeric region
namespace: cellular_component
alt_id: GO:0000784
def: "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "nuclear chromosome, telomere" NARROW []
synonym: "nuclear chromosome, telomeric region" NARROW []
synonym: "telomere" RELATED []
xref: SO:0000624
is_a: GO:0098687 ! chromosomal region

[Term]
id: GO:0000782
name: telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
is_a: GO:0032993 ! protein-DNA complex
relationship: part_of GO:0140445 ! chromosome, telomeric repeat region

[Term]
id: GO:0000783
name: nuclear telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
is_a: GO:0000782 ! telomere cap complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0000785
name: chromatin
namespace: cellular_component
alt_id: GO:0000789
alt_id: GO:0000790
alt_id: GO:0005717
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
synonym: "chromosome scaffold" RELATED []
synonym: "cytoplasmic chromatin" NARROW []
synonym: "nuclear chromatin" NARROW []
xref: NIF_Subcellular:sao1615953555
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000786
name: nucleosome
namespace: cellular_component
alt_id: GO:0000787
alt_id: GO:0000788
alt_id: GO:0005718
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
subset: goslim_pir
synonym: "cytoplasmic nucleosome" NARROW []
synonym: "nuclear nucleosome" NARROW []
xref: Wikipedia:Nucleosome
is_a: GO:0032993 ! protein-DNA complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0000791
name: euchromatin
namespace: cellular_component
alt_id: GO:0005719
alt_id: GO:0035327
def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]
synonym: "nuclear euchromatin" RELATED []
synonym: "transcriptionally active chromatin" EXACT []
xref: NIF_Subcellular:sao445485807
xref: Wikipedia:Euchromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000792
name: heterochromatin
namespace: cellular_component
alt_id: GO:0005720
alt_id: GO:0035328
def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]
synonym: "nuclear heterochromatin" NARROW []
synonym: "transcriptionally inactive chromatin" EXACT []
synonym: "transcriptionally silent chromatin" EXACT []
xref: NIF_Subcellular:sao581845896
xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000793
name: condensed chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis.
synonym: "cytoplasmic mitotic chromosome" RELATED []
synonym: "metaphase chromosome" RELATED []
synonym: "mitotic chromosome" RELATED []
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000794
name: condensed nuclear chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]
comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome.
synonym: "meiotic chromosome" RELATED []
synonym: "nuclear mitotic chromosome" RELATED []
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000793 ! condensed chromosome

[Term]
id: GO:0000795
name: synaptonemal complex
namespace: cellular_component
alt_id: GO:0005716
def: "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh]
xref: Wikipedia:Synaptonemal_complex
is_a: GO:0099086 ! synaptonemal structure

[Term]
id: GO:0000796
name: condensin complex
namespace: cellular_component
alt_id: GO:0000797
alt_id: GO:0000799
alt_id: GO:0005676
alt_id: GO:0008620
alt_id: GO:0008621
alt_id: GO:0061814
def: "A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis." [GOC:elh, PMID:17268547, PMID:21795393]
subset: goslim_pir
synonym: "13S condensin complex" NARROW []
synonym: "8S condensin complex" NARROW []
synonym: "condensin core heterodimer" NARROW []
synonym: "condensin I complex" NARROW []
synonym: "nuclear condensin complex" NARROW []
synonym: "SMC complex" RELATED []
synonym: "Smc2-Smc4 complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000800
name: lateral element
namespace: cellular_component
def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh]
comment: In species that have a synaptonemal complex, the lateral elements are part of this complex. S.pombe is an example of a species that lacks a (canonical) synaptonemal complex, but still has lateral elements.
synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000801
name: central element
namespace: cellular_component
def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000802
name: transverse filament
namespace: cellular_component
def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000803
name: sex chromosome
namespace: cellular_component
def: "A chromosome involved in sex determination." [GOC:elh]
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000804
name: W chromosome
namespace: cellular_component
def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000805
name: X chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system]
xref: Wikipedia:X_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000806
name: Y chromosome
namespace: cellular_component
def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system]
xref: Wikipedia:Y_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000807
name: Z chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000808
name: origin recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
subset: goslim_pir
synonym: "ORC" EXACT []
synonym: "origin of replication recognition complex" EXACT []
xref: Wikipedia:Origin_recognition_complex
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000809
name: cytoplasmic origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh]
synonym: "cytoplasmic ORC" EXACT []
synonym: "prokaryotic ORC" RELATED []
is_a: GO:0000808 ! origin recognition complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000810
name: diacylglycerol diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate." [GOC:kad, PMID:8567632, PMID:9452443, RHEA:27449]
synonym: "DGPP phosphatase activity" EXACT []
synonym: "DGPP phosphohydrolase activity" EXACT []
synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT []
xref: EC:3.6.1.75
xref: MetaCyc:RXN-11277
xref: RHEA:27449
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000811
name: GINS complex
namespace: cellular_component
def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]
synonym: "Go, Ichi, Ni and San complex" EXACT []
is_a: GO:0031261 ! DNA replication preinitiation complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0000812
name: Swr1 complex
namespace: cellular_component
def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820]
synonym: "SWR-C" EXACT []
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0097346 ! INO80-type complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0000813
name: ESCRT I complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "endosomal sorting complex required for transport" BROAD []
is_a: GO:0036452 ! ESCRT complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000814
name: ESCRT II complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "endosomal sorting complex required for transport" BROAD []
is_a: GO:0036452 ! ESCRT complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000815
name: ESCRT III complex
namespace: cellular_component
def: "A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission)." [PMID:17556548, PMID:22361144, PMID:28242692, PMID:31132588, PMID:32243490, PMID:34449766]
synonym: "endosomal sorting complex required for transport" BROAD []
is_a: GO:0036452 ! ESCRT complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000817
name: COMA complex
namespace: cellular_component
def: "A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p." [GOC:se, PMID:14633972]
synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0000819
name: sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0000820
name: regulation of glutamine family amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators]
synonym: "regulation of glutamine family amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0000821
name: regulation of arginine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]
synonym: "regulation of arginine metabolism" EXACT []
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006525 ! arginine metabolic process

[Term]
id: GO:0000822
name: inositol hexakisphosphate binding
namespace: molecular_function
def: "Binding to inositol hexakisphosphate." [GOC:go_curators]
synonym: "InsP6 binding" EXACT []
synonym: "IP6 binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0000823
name: inositol-1,4,5-trisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H+." [RHEA:17717]
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "inositol trisphosphate 6-kinase activity" BROAD []
synonym: "IpmK" BROAD []
xref: KEGG_REACTION:R05800
xref: MetaCyc:2.7.1.151-RXN
xref: RHEA:17717
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0000824
name: inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H+." [RHEA:11856]
synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" BROAD []
synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "inositol tetrakisphosphate 3-kinase activity" BROAD []
synonym: "IpmK" BROAD []
xref: KEGG_REACTION:R05801
xref: MetaCyc:RXN-7162
xref: Reactome:R-HSA-1855185 "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus"
xref: RHEA:11856
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000825
name: inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H+." [MetaCyc:RXN-7184]
synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" BROAD []
synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT []
synonym: "inositol tetrakisphosphate 6-kinase activity" BROAD []
xref: KEGG_REACTION:R10953
xref: MetaCyc:RXN-7184
xref: Reactome:R-HSA-1855206 "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus"
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000826
name: obsolete inositol pyrophosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326]
comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them.
synonym: "inositol diphosphate synthase activity" EXACT []
synonym: "inositol pyrophosphate synthase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0000827
name: inositol-1,3,4,5,6-pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242]
xref: Reactome:R-HSA-1855181 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus"
xref: Reactome:R-HSA-1855223 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol"
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0000828
name: inositol hexakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown." [GOC:elh, GOC:vw, PMID:16429326]
synonym: "IP6 kinase" EXACT []
xref: Reactome:R-HSA-1855207 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus"
xref: Reactome:R-HSA-1855216 "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol"
xref: Reactome:R-HSA-1855227 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol"
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0000829
name: diphosphoinositol pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326]
synonym: "inositol heptakisphosphate kinase activity" EXACT []
synonym: "PP-IP5 kinase activity" EXACT []
xref: Reactome:R-HSA-1855157 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus"
xref: Reactome:R-HSA-1855182 "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol"
xref: Reactome:R-HSA-1855194 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol"
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0000830
name: inositol hexakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000831
name: inositol hexakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000832
name: inositol hexakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP." [RHEA:12793]
synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT []
xref: KEGG_REACTION:R09087
xref: MetaCyc:2.7.1.152-RXN
xref: RHEA:12793
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000833
name: 5-diphosphoinositol pentakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = ADP + 4,5-bis(diphospho)-1D-myo-inositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326]
synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" BROAD []
synonym: "inositol heptakisphosphate 4-kinase activity" BROAD []
synonym: "IP7 4-kinase activity" EXACT []
is_a: GO:0000829 ! diphosphoinositol pentakisphosphate kinase activity

[Term]
id: GO:0000834
name: 5-diphosphoinositol pentakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = ADP + 5,6-bisdiphosphoinositol-1D-myo-inositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326]
synonym: "inositol heptakisphosphate 6-kinase activity" BROAD []
is_a: GO:0000829 ! diphosphoinositol pentakisphosphate kinase activity

[Term]
id: GO:0000835
name: ER ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the ER." [GOC:elh]
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0000836
name: Hrd1p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78)." [GOC:bf, GOC:elh, PMID:16619026, PMID:16873066, PMID:21454652]
synonym: "HRD1 ubiquitin ligase complex" RELATED [GOC:bf]
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000837
name: Doa10p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066]
synonym: "Ssm4p ubiquitin ligase complex" EXACT []
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000838
name: Hrd1p ubiquitin ligase ERAD-M complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000839
name: Hrd1p ubiquitin ligase ERAD-L complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000900
name: mRNA regulatory element binding translation repressor activity
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370]
synonym: "translation repressor activity, mRNA regulatory element binding" EXACT []
synonym: "translation repressor activity, nucleic acid binding" BROAD []
xref: Reactome:R-HSA-5690886 "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding

[Term]
id: GO:0000901
name: translation repressor activity, non-nucleic acid binding
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt]
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding

[Term]
id: GO:0000902
name: cell morphogenesis
namespace: biological_process
alt_id: GO:0007148
alt_id: GO:0045790
alt_id: GO:0045791
def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "cellular morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0000903
name: obsolete regulation of cell shape during vegetative growth phase
namespace: biological_process
alt_id: GO:0090061
def: "OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw]
comment: The reason for obsoletion is that biological phases should be captured as extensions.
synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw]
synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED []
is_obsolete: true

[Term]
id: GO:0000904
name: obsolete cell morphogenesis involved in differentiation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators]
comment: This term is equivalent to cell morphogenesis.
is_obsolete: true
replaced_by: GO:0000902

[Term]
id: GO:0000905
name: sporocarp development involved in asexual reproduction
namespace: biological_process
def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu]
synonym: "conidium development" NARROW []
synonym: "fruiting body formation involved in asexual reproduction" BROAD []
synonym: "haploid fruiting" RELATED []
synonym: "homokaryotic fruiting" RELATED []
synonym: "imperfect stage fruiting body development" NARROW []
synonym: "monokaryotic fruiting" RELATED []
is_a: GO:0030584 ! sporocarp development
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0000906
name: 6,7-dimethyl-8-ribityllumazine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [PMID:7559556]
synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX]
xref: EC:2.5.1.78
xref: MetaCyc:LUMAZINESYN-RXN
xref: RHEA:26152
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0000907
name: sulfonate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [GOC:clt, PMID:10482536]
synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT []
synonym: "sulphonate dioxygenase activity" EXACT []
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0000908
name: taurine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite." [EC:1.14.11.17, RHEA:15909]
synonym: "2-aminoethanesulfonate dioxygenase activity" RELATED [EC:1.14.11.17]
synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" RELATED [EC:1.14.11.17]
synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" RELATED [EC:1.14.11.17]
xref: EC:1.14.11.17
xref: KEGG_REACTION:R05320
xref: MetaCyc:RXN0-299
xref: RHEA:15909
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0000909
name: sporocarp development involved in sexual reproduction
namespace: biological_process
def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu]
synonym: "ascus development" NARROW []
synonym: "fruiting body development involved in sexual reproduction" BROAD []
synonym: "fruiting body formation involved in sexual reproduction" BROAD []
synonym: "perfect stage fruiting body development" NARROW []
is_a: GO:0030584 ! sporocarp development
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0000910
name: cytokinesis
namespace: biological_process
alt_id: GO:0007104
alt_id: GO:0016288
alt_id: GO:0033205
def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "cell cycle cytokinesis" EXACT []
synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Cytokinesis
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051301 ! cell division

[Term]
id: GO:0000911
name: cytokinesis by cell plate formation
namespace: biological_process
def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt]
is_a: GO:0000910 ! cytokinesis

[Term]
id: GO:0000912
name: assembly of actomyosin apparatus involved in cytokinesis
namespace: biological_process
def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:mtg_cell_cycle]
synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah]
synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb]
synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0000913
name: preprophase band assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah]
synonym: "preprophase band formation" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000914
name: phragmoplast assembly
namespace: biological_process
def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt]
synonym: "phragmoplast formation" RELATED [GOC:dph]
is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000915
name: actomyosin contractile ring assembly
namespace: biological_process
alt_id: GO:0045573
alt_id: GO:2000708
def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
synonym: "constriction ring assembly" NARROW []
synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin contractile ring assembly" EXACT []
synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED []
synonym: "cytokinesis, actomyosin ring formation" RELATED []
synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah]
synonym: "myosin filament organisation involved in cytokinetic actomyosin contractile ring assembly" RELATED [GOC:mah]
synonym: "myosin filament organization involved in cytokinetic actomyosin contractile ring assembly" RELATED []
synonym: "myosin filament organization of constriction ring assembly" RELATED [GOC:obol]
synonym: "myosin filament organization of contractile ring assembly" RELATED [GOC:obol]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis
is_a: GO:0044837 ! actomyosin contractile ring organization

[Term]
id: GO:0000916
name: actomyosin contractile ring contraction
namespace: biological_process
def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
synonym: "actomyosin contractile ring constriction" EXACT [GOC:vw]
synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "cytokinesis, actomyosin ring contraction" EXACT []
synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb]
is_a: GO:0036213 ! contractile ring contraction
relationship: part_of GO:0044837 ! actomyosin contractile ring organization

[Term]
id: GO:0000917
name: division septum assembly
namespace: biological_process
alt_id: GO:0071937
alt_id: GO:1902411
def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material." [GOC:mtg_cell_cycle]
synonym: "division septum assembly involved in cell cycle cytokinesis" NARROW []
synonym: "division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "division septum formation" EXACT [GOC:mah]
synonym: "division septum formation involved in cell cycle cytokinesis" NARROW []
synonym: "division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "division septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "formation of division septum" EXACT []
synonym: "formation of division septum involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "mitotic division septum assembly" NARROW []
synonym: "septation" BROAD []
synonym: "septin assembly and septum biosynthesis" RELATED []
synonym: "septin assembly and septum biosynthesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "septin assembly and septum formation" RELATED []
synonym: "septin assembly and septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie]
is_a: GO:0090529 ! cell septum assembly

[Term]
id: GO:0000918
name: division septum site selection
namespace: biological_process
def: "The process of marking the site where a division septum will form." [GOC:clt]
synonym: "selection of site for barrier cell septum biosynthesis" EXACT []
synonym: "selection of site for barrier cell septum formation" EXACT []
synonym: "selection of site for division septum formation" EXACT []
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
synonym: "septum positioning" EXACT []
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000917 ! division septum assembly

[Term]
id: GO:0000919
name: cell plate assembly
namespace: biological_process
def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt]
synonym: "cell plate formation" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000920
name: septum digestion after cytokinesis
namespace: biological_process
alt_id: GO:1902409
alt_id: GO:2000695
def: "The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:vw]
comment: This term should not be used to describe the last step of cytokinesis in organisms without a cell wall, ie, the cell resealing of the plasma membrane via abscission. Consider annotating to 'GO:0061952 midbody abscission' to capture this process.
synonym: "cell separation after cytokinesis" RELATED []
synonym: "cell separation following cytokinesis" EXACT [GOC:dph, GOC:tb]
synonym: "cytokinetic cell separation" RELATED []
synonym: "daughter cell separation" RELATED []
synonym: "mitotic cytokinetic cell separation" BROAD []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0051301 ! cell division

[Term]
id: GO:0000921
name: septin ring assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt]
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
is_a: GO:0031106 ! septin ring organization
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:0000922
name: spindle pole
namespace: cellular_component
alt_id: GO:0030615
def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0000923
name: equatorial microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817]
synonym: "EMTOC" EXACT []
synonym: "equatorial microtubule organising centre" EXACT []
is_a: GO:0005815 ! microtubule organizing center
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0000930
name: gamma-tubulin complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005815 ! microtubule organizing center

[Term]
id: GO:0000931
name: gamma-tubulin ring complex
namespace: cellular_component
alt_id: GO:0000924
alt_id: GO:0000925
alt_id: GO:0000926
alt_id: GO:0000929
alt_id: GO:0008274
alt_id: GO:0055031
alt_id: GO:0055032
alt_id: GO:0055033
alt_id: GO:0061494
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075, PMID:17021256]
synonym: "gamma-tubulin large complex" RELATED []
synonym: "gamma-tubulin large complex, centrosomal" NARROW []
synonym: "gamma-tubulin large complex, eMTOC" NARROW []
synonym: "gamma-tubulin large complex, equatorial microtubule organizing center" NARROW []
synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" NARROW []
synonym: "gamma-tubulin large complex, iMTOC" NARROW []
synonym: "gamma-tubulin large complex, interphase microtubule organizing center" NARROW []
synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" NARROW []
synonym: "gamma-tubulin large complex, mitotic spindle pole body" NARROW []
synonym: "gamma-tubulin large complex, spindle pole body" NARROW []
synonym: "gamma-tubulin ring complex, centrosomal" NARROW []
synonym: "gamma-TuRC" EXACT []
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0000932
name: P-body
namespace: cellular_component
def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]
synonym: "cytoplasmic foci" RELATED []
synonym: "cytoplasmic mRNA processing body" EXACT []
synonym: "P body" EXACT []
xref: Wikipedia:P_body
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0000933
name: adventitious septum
namespace: cellular_component
def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526]
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000934
name: porous cell septum
namespace: cellular_component
def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt]
synonym: "porous septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000935
name: division septum
namespace: cellular_component
alt_id: GO:0043187
def: "A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt, GOC:vw]
synonym: "cell septum surface" RELATED []
synonym: "complete septum" EXACT []
synonym: "septum surface" BROAD []
is_a: GO:0030428 ! cell septum
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0000936
name: primary cell septum
namespace: cellular_component
def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526]
synonym: "primary septum" BROAD []
is_a: GO:0000935 ! division septum

[Term]
id: GO:0000937
name: dolipore septum
namespace: cellular_component
def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt]
is_a: GO:0000934 ! porous cell septum

[Term]
id: GO:0000938
name: GARP complex
namespace: cellular_component
def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]
synonym: "Golgi associated retrograde protein complex" EXACT []
synonym: "VFT tethering complex" EXACT []
synonym: "Vps fifty three tethering complex" EXACT []
is_a: GO:0099023 ! vesicle tethering complex
relationship: part_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0000939
name: inner kinetochore
namespace: cellular_component
alt_id: GO:0000941
def: "The region of a kinetochore closest to centromeric DNA which contains many CENP proteins organized in various subcomplexes including CENP-C, CENP-LN, CENP-HIKM, CENP-OPQUR and CENP-TWSX, but excluding the CENP-A containing heterochromatin." [GOC:clt, PMID:10619130, PMID:11483983, PMID:32516549]
synonym: "condensed chromosome inner kinetochore" EXACT []
synonym: "condensed nuclear chromosome inner kinetochore" EXACT []
synonym: "inner centromere core complex" RELATED []
synonym: "inner kinetochore of condensed chromosome" EXACT []
synonym: "inner kinetochore of condensed nuclear chromosome" EXACT []
synonym: "inner kinetochore plate" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0000940
name: outer kinetochore
namespace: cellular_component
alt_id: GO:0000942
def: "The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
synonym: "condensed chromosome outer kinetochore" EXACT []
synonym: "condensed nuclear chromosome outer kinetochore" EXACT []
synonym: "outer kinetochore of condensed chromosome" EXACT []
synonym: "outer kinetochore of condensed nuclear chromosome" EXACT []
synonym: "outer kinetochore plate" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0000943
name: retrotransposon nucleocapsid
namespace: cellular_component
def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903]
synonym: "Virus-like particle" EXACT []
synonym: "VLP" EXACT []
xref: Wikipedia:Virus-like_particle
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000947
name: amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0000948
name: amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0000949
name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000950
name: branched-chain amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
synonym: "branched chain family amino acid catabolic process to alcohol via Ehrlich pathway" EXACT [GOC:krc]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009083 ! branched-chain amino acid catabolic process

[Term]
id: GO:0000951
name: methionine catabolic process to 3-methylthiopropanol
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009087 ! methionine catabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0000952
name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000953
name: branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
synonym: "branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway" EXACT [GOC:krc]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009083 ! branched-chain amino acid catabolic process

[Term]
id: GO:0000954
name: methionine catabolic process to 3-methylthiopropanoate
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0009087 ! methionine catabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0000955
name: amino acid catabolic process via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0009063 ! amino acid catabolic process

[Term]
id: GO:0000956
name: nuclear-transcribed mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]
synonym: "nuclear mRNA breakdown" EXACT []
synonym: "nuclear mRNA catabolism" EXACT []
synonym: "nuclear mRNA degradation" EXACT []
is_a: GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0000957
name: mitochondrial RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0000958
name: mitochondrial mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000957 ! mitochondrial RNA catabolic process
is_a: GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0000959
name: mitochondrial RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0000960
name: regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000961
name: negative regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:1902369 ! negative regulation of RNA catabolic process
relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000962
name: positive regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000963
name: mitochondrial RNA processing
namespace: biological_process
def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0006396 ! RNA processing
is_a: GO:0140053 ! mitochondrial gene expression

[Term]
id: GO:0000964
name: mitochondrial RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 5' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0000966 ! RNA 5'-end processing

[Term]
id: GO:0000965
name: mitochondrial RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 3' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0000966
name: RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc]
synonym: "RNA 5' end processing" EXACT []
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0000967
name: rRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc]
synonym: "rRNA 5' end processing" EXACT []
is_a: GO:0000966 ! RNA 5'-end processing
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000968
name: tRNA exon ligation
namespace: biological_process
def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc]
is_a: GO:0000378 ! RNA exon ligation
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000969
name: obsolete tRNA exon ligation utilizing ATP as source of linkage phosphate
namespace: biological_process
def: "OBSOLETE. A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051]
comment: The reason for obsoletion is that this term is a molecular functions.
is_obsolete: true

[Term]
id: GO:0000970
name: obsolete tRNA exon ligation utilizing GTP as source of linkage phosphate
namespace: biological_process
def: "OBSOLETE. A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409]
comment: The reason for obsoletion is that this term is a molecular function
is_obsolete: true
consider: GO:0000968

[Term]
id: GO:0000971
name: obsolete tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
namespace: biological_process
def: "OBSOLETE. A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409]
comment: The reason for obsoletion is that this term is a molecular function.
is_obsolete: true
consider: GO:0000968

[Term]
id: GO:0000972
name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0000973
name: post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049]
synonym: "posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery" EXACT []
is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

[Term]
id: GO:0000974
name: Prp19 complex
namespace: cellular_component
def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]
synonym: "MOS4-Associated Complex" NARROW [PMID:28947490]
synonym: "nineteen complex" NARROW []
synonym: "NTC" RELATED []
synonym: "Prp19/CDC5 complex" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0000976
name: transcription cis-regulatory region binding
namespace: molecular_function
alt_id: GO:0000975
alt_id: GO:0000984
alt_id: GO:0001017
alt_id: GO:0044212
def: "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
comment: Note that this term is meant to also capture non-specific binding to regulatory regions. Also, to minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription.
synonym: "bacterial-type RNA polymerase regulatory region DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding" NARROW []
synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" NARROW []
synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" NARROW []
synonym: "regulatory region DNA binding" BROAD []
synonym: "transcription regulatory region DNA binding" RELATED []
synonym: "transcription regulatory region sequence-specific DNA binding" EXACT []
is_a: GO:0001067 ! transcription regulatory region nucleic acid binding
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0000977
name: RNA polymerase II transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001012
def: "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription.
synonym: "RNA polymerase II regulatory region DNA binding" RELATED []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0000978
name: RNA polymerase II cis-regulatory region sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0000980
def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]
comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to cis-regulatory sequences. In bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is usually a synonym for "enhancer".
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding" RELATED []
synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding" RELATED []
synonym: "RNA polymerase II promoter proximal region sequence-specific DNA binding" RELATED []
synonym: "RNA polymerase II proximal promoter sequence-specific DNA binding" RELATED []
synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED []
is_a: GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
is_a: GO:0000987 ! cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0000979
name: RNA polymerase II core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene." [GOC:pg, GOC:txnOH, PMID:12381658]
is_a: GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
is_a: GO:0001046 ! core promoter sequence-specific DNA binding

[Term]
id: GO:0000981
name: DNA-binding transcription factor activity, RNA polymerase II-specific
namespace: molecular_function
alt_id: GO:0000982
alt_id: GO:0001133
alt_id: GO:0001200
alt_id: GO:0001201
alt_id: GO:0001202
alt_id: GO:0001203
alt_id: GO:0003705
def: "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]
comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW []
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW []
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW []
synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity" NARROW []
synonym: "RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, sequence-specific DNA binding" EXACT []
synonym: "RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding" EXACT []
synonym: "RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW []
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity" NARROW []
synonym: "sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
synonym: "sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity" RELATED []
synonym: "transcription factor" BROAD [GOC:vw]
synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW []
synonym: "transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW []
synonym: "transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW []
synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW []
is_a: GO:0003700 ! DNA-binding transcription factor activity

[Term]
id: GO:0000987
name: cis-regulatory region sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0000986
alt_id: GO:0001150
alt_id: GO:0001158
alt_id: GO:0001159
alt_id: GO:0035326
def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]
synonym: "bacterial-type cis-regulatory region sequence-specific DNA binding" NARROW []
synonym: "bacterial-type proximal promoter sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase enhancer sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding" NARROW []
synonym: "cis-regulatory region binding" RELATED []
synonym: "core promoter proximal region DNA binding" NARROW []
synonym: "core promoter proximal region sequence-specific DNA binding" NARROW []
synonym: "enhancer binding" RELATED []
synonym: "enhancer sequence-specific DNA binding" RELATED []
synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" NARROW []
synonym: "promoter proximal region sequence-specific DNA binding" NARROW []
synonym: "proximal promoter sequence-specific DNA binding" NARROW []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0000988
name: obsolete transcription factor activity, protein binding
namespace: molecular_function
def: "OBSOLETE. Binding to a protein or protein complex, to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "protein binding transcription factor activity" EXACT []
synonym: "transcription factor activity" BROAD []
is_obsolete: true
consider: GO:0005515
consider: GO:0140110

[Term]
id: GO:0000989
name: obsolete transcription factor activity, transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "transcription factor binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0008134
consider: GO:0140110

[Term]
id: GO:0000990
name: obsolete transcription factor activity, core RNA polymerase binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "core RNA polymerase binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0043175
consider: GO:0140110

[Term]
id: GO:0000991
name: obsolete transcription factor activity, core RNA polymerase II binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "core RNA polymerase II binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000993
consider: GO:0140110

[Term]
id: GO:0000992
name: RNA polymerase III cis-regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659]
is_a: GO:0000987 ! cis-regulatory region sequence-specific DNA binding
is_a: GO:0001016 ! RNA polymerase III transcription regulatory region sequence-specific DNA binding

[Term]
id: GO:0000993
name: RNA polymerase II complex binding
namespace: molecular_function
def: "Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH]
synonym: "RNA polymerase II core binding" EXACT []
synonym: "RNAP II core binding" EXACT []
is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding
is_a: GO:0043175 ! RNA polymerase core enzyme binding

[Term]
id: GO:0000994
name: RNA polymerase III core binding
namespace: molecular_function
def: "Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH]
is_a: GO:0043175 ! RNA polymerase core enzyme binding

[Term]
id: GO:0000995
name: RNA polymerase III general transcription initiation factor activity
namespace: molecular_function
alt_id: GO:0001034
def: "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III." [GOC:txnOH-2018, PMID:12381659, PMID:17977614, PMID:20413673, PMID:27068803, Wikipedia:RNA_polymerase_III]
synonym: "core RNA polymerase III binding transcription factor activity" NARROW []
synonym: "RNA polymerase III general initiation factor activity" EXACT []
synonym: "RNA polymerase III transcription factor activity, sequence-specific DNA binding" NARROW []
synonym: "sequence-specific DNA binding RNA polymerase III transcription factor activity" NARROW []
synonym: "transcription factor activity, core RNA polymerase III binding" NARROW []
is_a: GO:0140223 ! general transcription initiation factor activity

[Term]
id: GO:0001000
name: bacterial-type RNA polymerase core enzyme binding
namespace: molecular_function
def: "Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH]
comment: Should omega be included here?
synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT []
is_a: GO:0043175 ! RNA polymerase core enzyme binding

[Term]
id: GO:0001001
name: mitochondrial single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182]
is_a: GO:0001050 ! single-subunit type RNA polymerase binding

[Term]
id: GO:0001002
name: RNA polymerase III type 1 promoter sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001030
def: "Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 1 promoter DNA binding" RELATED []
is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding
is_a: GO:0080084 ! 5S rDNA binding

[Term]
id: GO:0001003
name: RNA polymerase III type 2 promoter sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001031
def: "Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 2 promoter DNA binding" RELATED []
is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0001004
name: obsolete RNA polymerase III transcription regulator recruiting activity
namespace: molecular_function
alt_id: GO:0001005
alt_id: GO:0001008
alt_id: GO:0001033
alt_id: GO:0001038
alt_id: GO:0001157
def: "OBSOLETE. Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB." [GOC:txnOH-2018, PMID:12381659, PMID:23063749, PMID:27911719, Wikipedia:RNA_polymerase_III]
comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'.
synonym: "RNA polymerase III assembly factor activity" RELATED []
synonym: "RNA polymerase III assembly factor activity, TFIIIB recruiting" RELATED []
synonym: "RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity" NARROW []
synonym: "RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW []
synonym: "RNA polymerase III transcription factor recruiting activity" EXACT []
synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW []
synonym: "RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW []
synonym: "RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity" NARROW []
synonym: "SNAPc-type activity" RELATED []
synonym: "TFIIIA activity" RELATED []
synonym: "TFIIIC-type activity" RELATED []
synonym: "transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting" EXACT []
synonym: "transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting" NARROW []
synonym: "transcription factor activity, RNA polymerase III type 1 promoter TFIIIB" RELATED []
synonym: "transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting" NARROW []
synonym: "transcription factor activity, RNA polymerase III type 3 promoter TFIIIB recruiting" NARROW []
synonym: "type 2 RNA polymerase III promoter recognition" NARROW []
synonym: "type 3 RNA polymerase III promoter recognition" NARROW []
is_obsolete: true

[Term]
id: GO:0001006
name: RNA polymerase III type 3 promoter sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001032
def: "Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 3 promoter DNA binding" RELATED []
is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0001007
name: obsolete transcription factor activity, RNA polymerase III transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "RNA polymerase III transcription factor binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001010
name: RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
namespace: molecular_function
def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH]
synonym: "sequence-specific DNA binding transcription factor recruiting transcription factor activity" EXACT []
synonym: "transcription factor activity, sequence-specific DNA binding transcription factor recruiting" EXACT []
synonym: "transcription factor activity, sequence-specific DNA-binding transcription factor recruiting" RELATED []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0001011
name: obsolete transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
namespace: molecular_function
def: "OBSOLETE. Binding to a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH]
comment: This term was obsoleted because it was not clearly defined and usage has been inconsistent.
synonym: "sequence-specific DNA binding RNA polymerase recruiting transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0140223

[Term]
id: GO:0001014
name: snoRNA transcription by RNA polymerase III
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH]
synonym: "snoRNA transcription from a type 2 RNA polymerase III promoter" NARROW []
is_a: GO:0006383 ! transcription by RNA polymerase III
is_a: GO:0009302 ! sno(s)RNA transcription

[Term]
id: GO:0001015
name: snoRNA transcription by RNA polymerase II
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH]
synonym: "snoRNA transcription from an RNA polymerase II promoter" EXACT []
is_a: GO:0006366 ! transcription by RNA polymerase II
is_a: GO:0009302 ! sno(s)RNA transcription

[Term]
id: GO:0001016
name: RNA polymerase III transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:12381659]
synonym: "RNA polymerase III regulatory region DNA binding" RELATED []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0001018
name: mitochondrial promoter sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0000997
alt_id: GO:0001044
alt_id: GO:0001045
alt_id: GO:0070361
alt_id: GO:0070362
alt_id: GO:0070363
alt_id: GO:0070364
def: "Binding to a DNA region that controls the transcription of the mitochondrial DNA." [GOC:txnOH, GOC:vw, PMID:20056105]
synonym: "HSP coding strand binding" NARROW [PMID:9485316]
synonym: "HSP non-coding strand binding" NARROW [PMID:9485316]
synonym: "HSPas binding" NARROW [PMID:9485316]
synonym: "HSPs binding" NARROW [PMID:9485316]
synonym: "LSP coding strand binding" NARROW [PMID:9485316]
synonym: "LSP non-coding strand binding" NARROW [PMID:9485316]
synonym: "LSPas binding" NARROW [PMID:9485316]
synonym: "LSPs binding" NARROW [PMID:9485316]
synonym: "mitochondrial heavy strand promoter anti-sense binding" NARROW []
synonym: "mitochondrial heavy strand promoter sense binding" NARROW []
synonym: "mitochondrial light strand promoter anti-sense binding" NARROW []
synonym: "mitochondrial light strand promoter sense binding" NARROW []
synonym: "mitochondrial proximal promoter sequence-specific DNA binding" RELATED []
synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding" RELATED []
synonym: "mitochondrial RNA polymerase core promoter sequence-specific DNA binding" RELATED []
synonym: "mitochondrial RNA polymerase regulatory region DNA binding" RELATED []
synonym: "mitochondrial RNA polymerase regulatory region sequence-specific DNA binding" RELATED []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0001019
name: plastid promoter transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw]
comment: plastid promoter regulatory region sequence-specific DNA binding
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0001025
name: RNA polymerase III general transcription initiation factor binding
namespace: molecular_function
def: "Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH]
synonym: "RNA polymerase III transcription factor binding" BROAD []
is_a: GO:0140296 ! general transcription initiation factor binding

[Term]
id: GO:0001026
name: obsolete TFIIIB-type transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH]
comment: This term was obsoleted because it represents a gene product.
synonym: "RNA polymerase III recruiting transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001027
name: obsolete RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659]
comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter.
synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED []
is_obsolete: true

[Term]
id: GO:0001028
name: obsolete RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659]
comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter.
synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED []
is_obsolete: true

[Term]
id: GO:0001029
name: obsolete RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659]
synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED []
is_obsolete: true

[Term]
id: GO:0001039
name: RNA polymerase III hybrid type promoter sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001037
def: "Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III hybrid type promoter DNA binding" RELATED []
is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0001040
name: obsolete RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659]
comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter.
is_obsolete: true

[Term]
id: GO:0001042
name: RNA polymerase I core binding
namespace: molecular_function
def: "Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH]
is_a: GO:0043175 ! RNA polymerase core enzyme binding

[Term]
id: GO:0001046
name: core promoter sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0000985
alt_id: GO:0001047
def: "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH]
synonym: "bacterial-type RNA polymerase core promoter sequence-specific DNA binding" NARROW []
synonym: "core promoter binding" RELATED []
synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" NARROW []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0001048
name: RNA polymerase IV core binding
namespace: molecular_function
def: "Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459]
is_a: GO:0043175 ! RNA polymerase core enzyme binding

[Term]
id: GO:0001049
name: RNA polymerase V core binding
namespace: molecular_function
def: "Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459]
is_a: GO:0043175 ! RNA polymerase core enzyme binding

[Term]
id: GO:0001050
name: single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995]
synonym: "SP6-type RNA polymerase binding" EXACT []
synonym: "T3-type RNA polymerase binding" EXACT []
synonym: "T3/T7 type RNA polymerase binding" EXACT []
synonym: "T7-type RNA polymerase binding" EXACT []
is_a: GO:0070063 ! RNA polymerase binding

[Term]
id: GO:0001051
name: plastid single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995]
is_a: GO:0001050 ! single-subunit type RNA polymerase binding

[Term]
id: GO:0001052
name: plastid PEP RNA polymerase core enzyme binding
namespace: molecular_function
def: "Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995]
is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding

[Term]
id: GO:0001054
name: RNA polymerase I activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity

[Term]
id: GO:0001055
name: RNA polymerase II activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT []
xref: Reactome:R-HSA-6814549 "Pre-snRNA transcript initiation, Integrator binding, LEC binding"
xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine"
is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity

[Term]
id: GO:0001056
name: RNA polymerase III activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT []
xref: Reactome:R-HSA-1964482 "RNA polymerase III transcribes microbial dsDNA to dsRNA"
is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity

[Term]
id: GO:0001057
name: RNA polymerase IV activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT []
is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity

[Term]
id: GO:0001058
name: RNA polymerase V activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT []
is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity

[Term]
id: GO:0001059
name: transcription by RNA polymerase IV
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459]
synonym: "transcription from RNA pol IV promoter" EXACT []
synonym: "transcription from RNA polymerase IV promoter" EXACT []
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0001060
name: transcription by RNA polymerase V
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459]
synonym: "transcription from RNA pol V promoter" EXACT []
synonym: "transcription from RNA polymerase V promoter" EXACT []
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0001061
name: obsolete bacterial-type RNA polymerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
comment: This term was obsoleted because the activity is the same as its parent.
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0001062
name: obsolete plastid PEP-A RNA polymerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
comment: This term was obsoleted because the activity is the same as its parent.
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0001063
name: obsolete plastid PEP-B RNA polymerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
comment: This term was obsoleted because the activity is the same as its parent.
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0001064
name: single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "T3/T7 type RNA polymerase activity" EXACT []
is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity

[Term]
id: GO:0001065
name: mitochondrial single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
is_a: GO:0001064 ! single subunit type RNA polymerase activity

[Term]
id: GO:0001066
name: plastid single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
is_a: GO:0001064 ! single subunit type RNA polymerase activity

[Term]
id: GO:0001067
name: transcription regulatory region nucleic acid binding
namespace: molecular_function
def: "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
synonym: "regulatory region nucleic acid binding" RELATED []
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0001068
name: transcription regulatory region RNA binding
namespace: molecular_function
def: "Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon." [GOC:txnOH]
is_a: GO:0001069 ! regulatory region RNA binding

[Term]
id: GO:0001069
name: regulatory region RNA binding
namespace: molecular_function
def: "Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
is_a: GO:0001067 ! transcription regulatory region nucleic acid binding
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0001070
name: RNA-binding transcription regulator activity
namespace: molecular_function
def: "A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences." [GOC:txnOH-2018, PMID:1756726]
synonym: "RNA binding transcription factor activity" RELATED []
synonym: "RNA binding transcription regulator activity" EXACT []
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0001072
name: transcription antitermination factor activity, RNA binding
namespace: molecular_function
def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211]
synonym: "RNA binding transcription antitermination factor activity" EXACT []
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0001073
name: transcription antitermination factor activity, DNA binding
namespace: molecular_function
def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211]
synonym: "DNA binding transcription antitermination factor activity" EXACT []
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0001074
name: obsolete transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly
namespace: molecular_function
def: "OBSOLETE. Binding to a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" EXACT []
synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding involved in preinitiation complex assembly" EXACT []
is_obsolete: true

[Term]
id: GO:0001076
name: obsolete transcription factor activity, RNA polymerase II transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "RNA polymerase II transcription factor binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0061629
consider: GO:0140110

[Term]
id: GO:0001079
name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II
is_a: GO:0090293 ! nitrogen catabolite regulation of transcription

[Term]
id: GO:0001080
name: nitrogen catabolite activation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0090294 ! nitrogen catabolite activation of transcription

[Term]
id: GO:0001081
name: nitrogen catabolite repression of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0090295 ! nitrogen catabolite repression of transcription

[Term]
id: GO:0001082
name: obsolete transcription factor activity, RNA polymerase I transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "RNA polymerase I transcription factor binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001083
name: obsolete transcription factor activity, RNA polymerase II basal transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "RNA polymerase II basal transcription factor binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001084
name: obsolete transcription factor activity, TFIID-class binding
namespace: molecular_function
def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "TFIID-class binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0001094

[Term]
id: GO:0001086
name: obsolete transcription factor activity, TFIIA-class binding
namespace: molecular_function
def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "TFIIA-class binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0001092

[Term]
id: GO:0001087
name: obsolete transcription factor activity, TFIIB-class binding
namespace: molecular_function
def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "TFIIB-class binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0001093

[Term]
id: GO:0001088
name: obsolete transcription factor activity, TFIIE-class binding
namespace: molecular_function
def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "TFIIE-class binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0001095

[Term]
id: GO:0001089
name: obsolete transcription factor activity, TFIIF-class transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "TFIIF-class binding transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0001096

[Term]
id: GO:0001090
name: obsolete transcription factor activity, TFIIH-class binding
namespace: molecular_function
def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "TFIIH-class binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001091
name: RNA polymerase II general transcription initiation factor binding
namespace: molecular_function
def: "Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867]
synonym: "RNA polymerase II basal transcription factor binding" EXACT []
is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding
is_a: GO:0140296 ! general transcription initiation factor binding

[Term]
id: GO:0001092
name: TFIIA-class transcription factor complex binding
namespace: molecular_function
def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
synonym: "TFIIA-class transcription factor binding" EXACT []
is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0001093
name: TFIIB-class transcription factor binding
namespace: molecular_function
def: "Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding

[Term]
id: GO:0001094
name: TFIID-class transcription factor complex binding
namespace: molecular_function
def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867]
synonym: "TFIID-class transcription factor binding" EXACT []
is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0001095
name: TFIIE-class transcription factor complex binding
namespace: molecular_function
def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867]
synonym: "TFIIE-class transcription factor binding" EXACT []
is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0001096
name: TFIIF-class transcription factor complex binding
namespace: molecular_function
def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867]
synonym: "TFIIF-class transcription factor binding" EXACT []
is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0001097
name: TFIIH-class transcription factor complex binding
namespace: molecular_function
def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867]
synonym: "TFIIH-class transcription factor binding" EXACT []
is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0001098
name: basal transcription machinery binding
namespace: molecular_function
def: "Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH]
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001099
name: basal RNA polymerase II transcription machinery binding
namespace: molecular_function
def: "Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH]
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
synonym: "basal RNAP II transcription machinery binding" EXACT []
is_a: GO:0001098 ! basal transcription machinery binding

[Term]
id: GO:0001100
name: negative regulation of exit from mitosis
namespace: biological_process
def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn]
synonym: "down regulation of exit from mitosis" EXACT []
synonym: "down-regulation of exit from mitosis" EXACT []
synonym: "downregulation of exit from mitosis" EXACT []
synonym: "inhibition of exit from mitosis" NARROW []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
relationship: negatively_regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0001101
name: response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
subset: gocheck_do_not_annotate
synonym: "response to acid" BROAD []
synonym: "response to acid anion" RELATED []
synonym: "response to oxoanion" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0001108
name: bacterial-type RNA polymerase holo enzyme binding
namespace: molecular_function
def: "Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH]
synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT []
is_a: GO:0001098 ! basal transcription machinery binding

[Term]
id: GO:0001109
name: promoter clearance during DNA-templated transcription
namespace: biological_process
alt_id: GO:0001122
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "promoter clearance during DNA-dependent transcription" EXACT [GOC:txnOH]
synonym: "promoter clearance from bacterial-type RNA polymerase promoter" NARROW []
synonym: "promoter escape" BROAD []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0001110
name: RNA polymerase III promoter clearance
namespace: biological_process
def: "A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH]
synonym: "promoter clearance from RNA polymerase III promoter" EXACT []
is_a: GO:0001109 ! promoter clearance during DNA-templated transcription
relationship: part_of GO:0006383 ! transcription by RNA polymerase III

[Term]
id: GO:0001111
name: RNA polymerase II promoter clearance
namespace: biological_process
def: "A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:22982364, PMID:31628251]
synonym: "promoter clearance from RNA polymerase II promoter" EXACT []
synonym: "promoter escape from RNA polymerase II promoter" EXACT []
synonym: "promoter-paused RNA polymerase II release" EXACT []
is_a: GO:0001109 ! promoter clearance during DNA-templated transcription
relationship: part_of GO:0006366 ! transcription by RNA polymerase II

[Term]
id: GO:0001112
name: DNA-templated transcription open complex formation
namespace: biological_process
alt_id: GO:0001127
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "DNA-dependent transcriptional open complex formation" EXACT [GOC:txnOH]
synonym: "DNA-templated transcriptional open complex formation" EXACT []
synonym: "promoter melting" BROAD []
synonym: "transcription open complex formation at bacterial-type RNA polymerase promoter" NARROW []
synonym: "transcriptional open complex formation at bacterial-type RNA polymerase promoter" NARROW []
is_a: GO:0001120 ! protein-DNA complex remodeling
relationship: part_of GO:0006352 ! DNA-templated transcription initiation

[Term]
id: GO:0001113
name: transcription open complex formation at RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "RNA polymerase II promoter melting" EXACT []
synonym: "transcriptional open complex formation at RNA polymerase II promoter" EXACT []
is_a: GO:0001112 ! DNA-templated transcription open complex formation
relationship: part_of GO:0006367 ! transcription initiation at RNA polymerase II promoter

[Term]
id: GO:0001114
name: protein-DNA-RNA complex
namespace: cellular_component
def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0001115
name: protein-DNA-RNA complex organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH]
synonym: "protein-DNA-RNA complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0001116
name: protein-DNA-RNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex organization
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0001117
name: protein-DNA-RNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex organization
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0001118
name: transcription ternary complex disassembly
namespace: biological_process
def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH]
synonym: "transcription protein-DNA-RNA complex disassembly" EXACT []
is_a: GO:0001117 ! protein-DNA-RNA complex disassembly
relationship: part_of GO:0006353 ! DNA-templated transcription termination

[Term]
id: GO:0001119
name: protein-DNA-RNA complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex organization
is_a: GO:0034367 ! protein-containing complex remodeling

[Term]
id: GO:0001120
name: protein-DNA complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex." [GOC:txnOH]
synonym: "protein-DNA complex remodelling" EXACT []
is_a: GO:0034367 ! protein-containing complex remodeling
is_a: GO:0071824 ! protein-DNA complex organization

[Term]
id: GO:0001128
name: obsolete RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867]
comment: This term was obsoleted because it represented a mix of function and process and is not annotated consistently
synonym: "RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly" EXACT []
is_obsolete: true

[Term]
id: GO:0001129
name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
namespace: molecular_function
def: "OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW []
synonym: "TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT []
is_obsolete: true

[Term]
id: GO:0001132
name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding
namespace: molecular_function
def: "OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW []
synonym: "TBP-class protein binding RNA polymerase II transcription factor activity" EXACT []
synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW []
is_obsolete: true

[Term]
id: GO:0001134
name: obsolete transcription regulator recruiting activity
namespace: molecular_function
def: "OBSOLETE. The function of binding to an RNA polymerase (RNAP) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867]
comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'.
synonym: "transcription factor activity, transcription factor recruiting" RELATED []
synonym: "transcription factor recruiting activity" EXACT []
synonym: "transcription factor recruiting transcription factor activity" EXACT []
is_obsolete: true
replaced_by: GO:0003712

[Term]
id: GO:0001135
name: obsolete RNA polymerase II transcription regulator recruiting activity
namespace: molecular_function
alt_id: GO:0001136
alt_id: GO:0001137
alt_id: GO:0001138
def: "OBSOLETE. The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867]
comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'.
synonym: "RNA polymerase II transcription factor recruiting activity" EXACT []
synonym: "RNA polymerase II transcription factor recruiting transcription factor activity" EXACT []
synonym: "TFIIE-class transcription factor recruiting transcription factor activity" NARROW []
synonym: "TFIIF-class transcription factor recruiting transcription factor activity" NARROW []
synonym: "TFIIH-class transcription factor recruiting transcription factor activity" NARROW []
synonym: "transcription factor activity, RNA polymerase II transcription factor recruiting" RELATED []
synonym: "transcription factor activity, TFIIE-class transcription factor recruiting" NARROW []
synonym: "transcription factor activity, TFIIF-class transcription factor recruiting" NARROW []
synonym: "transcription factor activity, TFIIH-class transcription factor recruiting" NARROW []
is_obsolete: true
replaced_by: GO:0003712

[Term]
id: GO:0001139
name: RNA polymerase II complex recruiting activity
namespace: molecular_function
def: "Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867]
synonym: "core RNA polymerase II recruiting transcription factor activity" EXACT []
synonym: "transcription factor activity, core RNA polymerase II recruiting" RELATED []
is_a: GO:0000993 ! RNA polymerase II complex binding
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0001147
name: transcription termination site sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001145
alt_id: GO:0001146
alt_id: GO:0001148
alt_id: GO:0001160
def: "Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175]
comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a DNA specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation.
synonym: "bacterial-type RNA polymerase termination site sequence-specific DNA binding" NARROW []
synonym: "mitochondrial RNA polymerase termination site sequence-specific DNA binding" NARROW []
synonym: "mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity" NARROW []
synonym: "transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding" NARROW []
synonym: "transcription termination site DNA binding" RELATED []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0001149
name: obsolete transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding
namespace: molecular_function
def: "OBSOLETE. Binding to a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161]
synonym: "bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001152
name: obsolete transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting
namespace: molecular_function
def: "OBSOLETE. The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659]
comment: This term was made obsolete in the 2018 Transcription branch revision. This represents the activity of TFIIIA only.
synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity" EXACT []
synonym: "TFIIIA activity" RELATED []
synonym: "type 1 RNA polymerase III promoter recognition" EXACT []
is_obsolete: true

[Term]
id: GO:0001153
name: obsolete transcription factor activity, RNA polymerase III transcription factor recruiting
namespace: molecular_function
def: "OBSOLETE. The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH]
comment: This term was made obsolete in the 2018 Transcription branch revision. This term was redundant with other terms.
synonym: "RNA polymerase III transcription factor recruiting transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001154
name: TFIIIB-class transcription factor complex binding
namespace: molecular_function
def: "Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
synonym: "TFIIIB-class transcription factor binding" EXACT []
is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding

[Term]
id: GO:0001155
name: TFIIIA-class transcription factor binding
namespace: molecular_function
def: "Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters." [GOC:txnOH, PMID:12381659]
is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding

[Term]
id: GO:0001156
name: TFIIIC-class transcription factor complex binding
namespace: molecular_function
def: "Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
synonym: "TFIIIC-class transcription factor binding" EXACT []
is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding

[Term]
id: GO:0001161
name: intronic transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0044213
def: "Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH]
comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription.
synonym: "intronic transcription regulatory region DNA binding" RELATED []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0001162
name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH]
comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription.
is_a: GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding

[Term]
id: GO:0001163
name: RNA polymerase I transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001013
def: "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH]
synonym: "RNA polymerase I regulatory region DNA binding" RELATED []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0001164
name: RNA polymerase I core promoter sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001187
def: "Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I CORE element sequence-specific DNA binding" EXACT []
synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity" RELATED []
synonym: "transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting" RELATED []
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
is_a: GO:0001163 ! RNA polymerase I transcription regulatory region sequence-specific DNA binding

[Term]
id: GO:0001165
name: RNA polymerase I cis-regulatory region sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0001166
def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I enhancer sequence-specific DNA binding" RELATED []
synonym: "RNA polymerase I upstream control element sequence-specific DNA binding" RELATED []
synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED []
is_a: GO:0001163 ! RNA polymerase I transcription regulatory region sequence-specific DNA binding

[Term]
id: GO:0001167
name: obsolete RNA polymerase I transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
def: "OBSOLETE. Binding to a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "sequence-specific DNA binding RNA polymerase I transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001168
name: obsolete transcription factor activity, RNA polymerase I upstream control element sequence-specific binding
namespace: molecular_function
def: "OBSOLETE. Binding to a upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001169
name: obsolete transcription factor activity, RNA polymerase I CORE element sequence-specific binding
namespace: molecular_function
def: "OBSOLETE. Binding to CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "RNA polymerase I core promoter sequence-specific DNA binding transcription factor" EXACT []
is_obsolete: true

[Term]
id: GO:0001170
name: obsolete transcription factor activity, RNA polymerase I enhancer sequence-specific binding
namespace: molecular_function
def: "OBSOLETE. Binding to a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child.
synonym: "RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001171
name: reverse transcription
namespace: biological_process
def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252]
xref: Wikipedia:Reverse_transcription
is_a: GO:0006278 ! RNA-templated DNA biosynthetic process

[Term]
id: GO:0001172
name: RNA-templated transcription
namespace: biological_process
def: "The synthesis of an RNA transcript from an RNA template." [GOC:txnOH]
synonym: "transcription, RNA-dependent" EXACT [GOC:txnOH]
synonym: "transcription, RNA-templated" EXACT []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0001173
name: DNA-templated transcriptional start site selection
namespace: biological_process
alt_id: GO:0001176
def: "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
synonym: "DNA-dependent transcriptional start site selection" EXACT [GOC:txnOH]
synonym: "transcriptional start site selection at bacterial-type RNA polymerase promoter" NARROW []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006352 ! DNA-templated transcription initiation

[Term]
id: GO:0001174
name: transcriptional start site selection at RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
is_a: GO:0001173 ! DNA-templated transcriptional start site selection
relationship: part_of GO:0006367 ! transcription initiation at RNA polymerase II promoter

[Term]
id: GO:0001175
name: transcriptional start site selection at RNA polymerase III promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
is_a: GO:0001173 ! DNA-templated transcriptional start site selection
relationship: part_of GO:0006384 ! transcription initiation at RNA polymerase III promoter

[Term]
id: GO:0001177
name: regulation of transcription open complex formation at RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH]
synonym: "regulation of transcriptional open complex formation at RNA polymerase II promoter" EXACT []
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0001113 ! transcription open complex formation at RNA polymerase II promoter

[Term]
id: GO:0001178
name: regulation of transcriptional start site selection at RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
synonym: "regulation of transcription start site selection at RNA polymerase II promoter" EXACT []
is_a: GO:0010630 ! regulation of transcription, start site selection
is_a: GO:0060260 ! regulation of transcription initiation by RNA polymerase II
relationship: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter

[Term]
id: GO:0001179
name: RNA polymerase I general transcription initiation factor binding
namespace: molecular_function
def: "Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I." [GOC:txnOH]
synonym: "RNA polymerase I transcription factor binding" BROAD []
is_a: GO:0140296 ! general transcription initiation factor binding

[Term]
id: GO:0001181
name: RNA polymerase I general transcription initiation factor activity
namespace: molecular_function
def: "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs." [GOC:txnOH-2018, PMID:11500378, PMID:17972917, PMID:25346433, PMID:28340337, PMID:28842442, PMID:31358304]
synonym: "core RNA polymerase I binding transcription factor activity" BROAD []
synonym: "general RNA polymerase I transcription factor activity" EXACT []
synonym: "RNA polymerase I transcription general initiation factor activity" EXACT []
synonym: "transcription factor activity, core RNA polymerase I binding" BROAD []
is_a: GO:0140223 ! general transcription initiation factor activity

[Term]
id: GO:0001182
name: RNA polymerase I promoter clearance
namespace: biological_process
alt_id: GO:0001184
def: "A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:18559419]
synonym: "promoter clearance from RNA polymerase I promoter" EXACT []
synonym: "promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript" RELATED []
synonym: "RNA polymerase I promoter escape" EXACT []
is_a: GO:0001109 ! promoter clearance during DNA-templated transcription
relationship: part_of GO:0006360 ! transcription by RNA polymerase I

[Term]
id: GO:0001186
name: obsolete RNA polymerase I transcription regulator recruiting activity
namespace: molecular_function
def: "OBSOLETE. The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:12381659, PMID:14969726, PMID:8057832]
comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'.
synonym: "RNA polymerase I transcription factor recruiting activity" EXACT []
synonym: "RNA polymerase I transcription factor recruiting transcription factor activity" EXACT []
synonym: "transcription factor activity, RNA polymerase I transcription factor recruiting" RELATED []
is_obsolete: true
replaced_by: GO:0003712

[Term]
id: GO:0001188
name: RNA polymerase I preinitiation complex assembly
namespace: biological_process
alt_id: GO:0001189
def: "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which includes including UBF, SL1, RRN3 and TBP in human). The PIC engages RNA polymerase I on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH, PMID:14969726]
synonym: "RNA polymerase I transcriptional preinitiation complex assembly" EXACT []
synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript" NARROW []
synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript" NARROW []
is_a: GO:0070897 ! transcription preinitiation complex assembly
relationship: part_of GO:0006361 ! transcription initiation at RNA polymerase I promoter

[Term]
id: GO:0001190
name: obsolete transcriptional activator activity, RNA polymerase II transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "RNA polymerase II transcription factor binding transcription activator activity" EXACT []
synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription" EXACT []
is_obsolete: true
consider: GO:0001228
consider: GO:0061629

[Term]
id: GO:0001191
name: obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "RNA polymerase II transcription factor binding transcription repressor activity" EXACT []
synonym: "RNA polymerase II transcription repressor activity" BROAD []
is_obsolete: true
consider: GO:0001227
consider: GO:0061629

[Term]
id: GO:0001192
name: maintenance of transcriptional fidelity during transcription elongation
namespace: biological_process
alt_id: GO:0001194
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template." [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation" EXACT [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter" EXACT [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-templated transcription elongation" EXACT []
synonym: "maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter" NARROW []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006354 ! DNA-templated transcription elongation

[Term]
id: GO:0001193
name: maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter." [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter" EXACT [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0001192 ! maintenance of transcriptional fidelity during transcription elongation
relationship: part_of GO:0006368 ! transcription elongation by RNA polymerase II

[Term]
id: GO:0001195
name: maintenance of transcriptional fidelity during transcription elongation by RNA polymerase III
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter." [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter" EXACT [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter" EXACT []
is_a: GO:0001192 ! maintenance of transcriptional fidelity during transcription elongation
relationship: part_of GO:0006385 ! transcription elongation by RNA polymerase III

[Term]
id: GO:0001196
name: obsolete regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0001197
name: obsolete positive regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW []
synonym: "stimulation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW []
synonym: "up regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
synonym: "up-regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
synonym: "upregulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
is_obsolete: true

[Term]
id: GO:0001198
name: obsolete negative regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "down-regulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "downregulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "inhibition of RNA polymerase II transcription, mating-type specific" NARROW []
is_obsolete: true

[Term]
id: GO:0001207
name: obsolete histone displacement
namespace: biological_process
def: "OBSOLETE. The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0140713

[Term]
id: GO:0001208
name: obsolete histone H2A-H2B dimer displacement
namespace: biological_process
def: "OBSOLETE. The removal of a H2A-H2B histone dimer from a nucleosome within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0140713

[Term]
id: GO:0001216
name: DNA-binding transcription activator activity
namespace: molecular_function
alt_id: GO:0001140
alt_id: GO:0001215
def: "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018]
comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" RELATED []
synonym: "bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW []
synonym: "transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" RELATED []
is_a: GO:0003700 ! DNA-binding transcription factor activity

[Term]
id: GO:0001217
name: DNA-binding transcription repressor activity
namespace: molecular_function
alt_id: GO:0001141
alt_id: GO:0001218
alt_id: GO:0001219
alt_id: GO:0001220
def: "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets." [GOC:txnOH-2018]
comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
synonym: "bacterial-type DNA binding transcription repressor activity" NARROW []
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding" NARROW []
synonym: "cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW []
synonym: "transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW []
is_a: GO:0003700 ! DNA-binding transcription factor activity

[Term]
id: GO:0001221
name: transcription coregulator binding
namespace: molecular_function
alt_id: GO:0001224
def: "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]
synonym: "RNA polymerase II transcription cofactor binding" RELATED []
synonym: "RNA polymerase II transcription coregulator binding" RELATED []
synonym: "transcription cofactor binding" RELATED []
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0001222
name: transcription corepressor binding
namespace: molecular_function
alt_id: GO:0001226
def: "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc]
synonym: "RNA polymerase II transcription corepressor binding" RELATED []
is_a: GO:0001221 ! transcription coregulator binding

[Term]
id: GO:0001223
name: transcription coactivator binding
namespace: molecular_function
alt_id: GO:0001225
def: "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc]
synonym: "RNA polymerase II transcription coactivator binding" RELATED []
is_a: GO:0001221 ! transcription coregulator binding

[Term]
id: GO:0001227
name: DNA-binding transcription repressor activity, RNA polymerase II-specific
namespace: molecular_function
alt_id: GO:0001078
alt_id: GO:0001206
alt_id: GO:0001210
alt_id: GO:0001214
def: "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]
comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
synonym: "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW []
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW []
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW []
synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW []
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW []
synonym: "transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW []
synonym: "transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW []
synonym: "transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT []
is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
is_a: GO:0001217 ! DNA-binding transcription repressor activity

[Term]
id: GO:0001228
name: DNA-binding transcription activator activity, RNA polymerase II-specific
namespace: molecular_function
alt_id: GO:0001077
alt_id: GO:0001205
alt_id: GO:0001209
alt_id: GO:0001211
alt_id: GO:0001212
alt_id: GO:0001213
def: "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW []
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW []
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT []
synonym: "RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW []
synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding" NARROW []
synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW []
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW []
synonym: "transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW []
synonym: "transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding" NARROW []
synonym: "transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW []
synonym: "transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT []
synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW []
xref: Reactome:R-HSA-9856539 "MLXIPL:MLX binds PKLR gene promoter"
xref: Reactome:R-HSA-9856546 "MLXIPL:MLX binds FASN gene promoter"
xref: Reactome:R-HSA-9856548 "MLXIPL:MLX binds ACACB gene promoter"
xref: Reactome:R-HSA-9856549 "MLXIPL:MLX binds ACLY gene promoter"
xref: Reactome:R-HSA-9856550 "MLXIPL:MLX binds ACACA gene promoter"
xref: Reactome:R-HSA-9856604 "MLXIPL:MLX binds AGPAT1 gene promoter"
is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
is_a: GO:0001216 ! DNA-binding transcription activator activity

[Term]
id: GO:0001300
name: obsolete chronological cell aging
namespace: biological_process
def: "OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934]
comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process.
synonym: "chronological cell ageing" EXACT []
is_obsolete: true
consider: GO:0044838
consider: GO:0090398

[Term]
id: GO:0001301
name: obsolete progressive alteration of chromatin involved in cell aging
namespace: biological_process
def: "OBSOLETE. Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, GOC:vw, PMID:12044938]
comment: This term was obsoleted because it represents a phenotype.
synonym: "age-dependent accumulation of genetic damage" RELATED []
synonym: "progressive alteration of chromatin during cell ageing" EXACT []
synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001302
name: obsolete replicative cell aging
namespace: biological_process
def: "OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "replicative cell ageing" EXACT []
is_obsolete: true
consider: GO:0090399

[Term]
id: GO:0001303
name: obsolete nucleolar fragmentation involved in replicative aging
namespace: biological_process
def: "OBSOLETE. A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "nucleolar fragmentation during replicative ageing" RELATED []
synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001304
name: obsolete progressive alteration of chromatin involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT []
synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001305
name: obsolete progressive alteration of chromatin involved in chronological cell aging
namespace: biological_process
def: "OBSOLETE. A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb]
comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process.
synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED []
synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0044838
consider: GO:0090398

[Term]
id: GO:0001306
name: obsolete age-dependent response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true
consider: GO:0034599

[Term]
id: GO:0001307
name: obsolete extrachromosomal circular DNA accumulation involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED []
synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001308
name: obsolete negative regulation of chromatin silencing involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "loss of chromatin silencing during replicative cell ageing" RELATED []
synonym: "loss of chromatin silencing involved in replicative cell aging" EXACT []
is_obsolete: true

[Term]
id: GO:0001309
name: obsolete age-dependent telomere shortening
namespace: biological_process
def: "OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807]
comment: This term was made obsolete because it represents a phenotype.
synonym: "age-dependent telomere shortening" EXACT []
is_obsolete: true
consider: GO:1903824

[Term]
id: GO:0001310
name: obsolete extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED []
synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED []
is_obsolete: true

[Term]
id: GO:0001311
name: obsolete formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging" RELATED []
synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED []
synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED []
is_obsolete: true

[Term]
id: GO:0001312
name: obsolete replication of extrachromosomal rDNA circles involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED []
synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED []
is_obsolete: true

[Term]
id: GO:0001313
name: obsolete formation of extrachromosomal circular DNA involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "assembly of extrachromosomal circular DNA involved in replicative cell aging" EXACT []
synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED []
synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001314
name: obsolete replication of extrachromosomal circular DNA involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT []
synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001315
name: obsolete age-dependent response to reactive oxygen species
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
comment: This term was obsoleted because it represents a phenotype.
synonym: "age-dependent response to active oxygen species" EXACT []
synonym: "age-dependent response to AOS" EXACT []
synonym: "age-dependent response to reactive oxidative species" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate" EXACT []
synonym: "age-dependent response to ROI" EXACT []
synonym: "age-dependent response to ROS" EXACT []
is_obsolete: true
consider: GO:0034599

[Term]
id: GO:0001316
name: obsolete age-dependent response to reactive oxygen species involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED []
synonym: "age-dependent response to AOS during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT []
synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "age-dependent response to ROI during replicative cell aging" RELATED []
synonym: "age-dependent response to ROS during replicative cell aging" RELATED []
is_obsolete: true

[Term]
id: GO:0001317
name: obsolete accumulation of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001318
name: obsolete formation of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001319
name: obsolete inheritance of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001320
name: obsolete age-dependent response to reactive oxygen species involved in chronological cell aging
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process.
synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED []
synonym: "age-dependent response to AOS during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxidative species during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED []
synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "age-dependent response to ROI during chronological cell aging" RELATED []
synonym: "age-dependent response to ROS during chronological cell aging" RELATED []
is_obsolete: true
consider: GO:0044838
consider: GO:0090398

[Term]
id: GO:0001321
name: obsolete age-dependent general metabolic decline involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED []
synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001322
name: obsolete age-dependent response to oxidative stress involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED []
synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001323
name: obsolete age-dependent general metabolic decline involved in chronological cell aging
namespace: biological_process
def: "OBSOLETE. A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah]
comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process.
synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED []
synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0044838
consider: GO:0090398

[Term]
id: GO:0001324
name: obsolete age-dependent response to oxidative stress involved in chronological cell aging
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process.
synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED []
synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0044838
consider: GO:0090398

[Term]
id: GO:0001325
name: formation of extrachromosomal circular DNA
namespace: biological_process
def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938]
synonym: "assembly of extrachromosomal circular DNA" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0001326
name: replication of extrachromosomal circular DNA
namespace: biological_process
def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh, PMID:33867825]
is_a: GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0001400
name: mating projection base
namespace: cellular_component
def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc]
synonym: "base of shmoo tip" NARROW []
synonym: "conjugation tube base" NARROW []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0001401
name: SAM complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]
comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'.
synonym: "mitochondrial sorting and assembly machinery complex" EXACT []
synonym: "TOB complex" EXACT []
is_a: GO:0005742 ! mitochondrial outer membrane translocase complex

[Term]
id: GO:0001402
name: signal transduction involved in filamentous growth
namespace: biological_process
def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395]
synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED []
synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0030447 ! filamentous growth

[Term]
id: GO:0001403
name: invasive growth in response to glucose limitation
namespace: biological_process
def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395]
comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO.
subset: goslim_yeast
synonym: "colony morphology" RELATED []
is_a: GO:0036267 ! invasive filamentous growth

[Term]
id: GO:0001404
name: obsolete invasive growth
namespace: biological_process
def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "invasive growth" EXACT []
synonym: "tissue invasion" EXACT []
is_obsolete: true
consider: GO:0044409

[Term]
id: GO:0001405
name: PAM complex, Tim23 associated import motor
namespace: cellular_component
def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix." [GOC:mcc, GOC:vw, PMID:14517234, PMID:14638855]
synonym: "mitochondrial import motor" EXACT []
synonym: "PAM complex" EXACT []
synonym: "pre-sequence translocase-associated import motor" EXACT []
synonym: "presequence translocase-associated import motor" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005744 ! TIM23 mitochondrial import inner membrane translocase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0001406
name: glycerophosphodiester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity

[Term]
id: GO:0001407
name: glycerophosphodiester transmembrane transport
namespace: biological_process
def: "The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0001408
name: guanine nucleotide transport
namespace: biological_process
def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc]
is_a: GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0001409
name: guanine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other." [GOC:mcc]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity

[Term]
id: GO:0001410
name: chlamydospore formation
namespace: biological_process
alt_id: GO:0055027
def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094]
synonym: "chlamydospore development" EXACT []
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
is_a: GO:0048468 ! cell development

[Term]
id: GO:0001411
name: hyphal tip
namespace: cellular_component
def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc]
subset: goslim_candida
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0051286 ! cell tip

[Term]
id: GO:0001501
name: skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb]
synonym: "skeletal development" EXACT []
is_a: GO:0048731 ! system development

[Term]
id: GO:0001502
name: cartilage condensation
namespace: biological_process
def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437]
is_a: GO:0098743 ! cell aggregation
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0001503
name: ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]
comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
synonym: "bone biosynthesis" EXACT []
synonym: "bone formation" EXACT []
synonym: "osteogenesis" EXACT []
xref: Wikipedia:Ossification
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001504
name: neurotransmitter uptake
namespace: biological_process
def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
subset: goslim_synapse
synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "neurotransmitter import into glial cell" NARROW []
synonym: "neurotransmitter import into neuron" NARROW []
synonym: "neurotransmitter recycling" BROAD []
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0098657 ! import into cell

[Term]
id: GO:0001505
name: obsolete regulation of neurotransmitter levels
namespace: biological_process
def: "OBSOLETE. Any process that modulates levels of neurotransmitter." [GOC:jl]
comment: The reason for obsoletion is that 'neurotransmitter' is unnecessary grouping in the metabolism branch of the ontology, and it creates true path violations.
is_obsolete: true

[Term]
id: GO:0001506
name: obsolete neurotransmitter biosynthetic process and storage
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387]
comment: This term was made obsolete because it is an amalgamation of its two children.
synonym: "neurotransmitter anabolism and storage" EXACT []
synonym: "neurotransmitter biosynthetic process and storage" EXACT []
synonym: "neurotransmitter formation and storage" EXACT []
synonym: "neurotransmitter synthesis and storage" EXACT []
is_obsolete: true

[Term]
id: GO:0001507
name: acetylcholine catabolic process in synaptic cleft
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai]
synonym: "acetylcholine breakdown in synaptic cleft" EXACT []
synonym: "acetylcholine degradation in synaptic cleft" EXACT []
is_a: GO:0006581 ! acetylcholine catabolic process
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0001508
name: action potential
namespace: biological_process
def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0001509
name: obsolete legumain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "citvac" RELATED [EC:3.4.22.34]
synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34]
synonym: "legumain activity" EXACT []
synonym: "phaseolin activity" RELATED [EC:3.4.22.34]
synonym: "proteinase B" RELATED [EC:3.4.22.34]
synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34]
synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34]
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0001510
name: RNA methylation
namespace: biological_process
def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd, PMID:21823225]
is_a: GO:0009451 ! RNA modification
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0001511
name: obsolete fibrillin
namespace: molecular_function
def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "fibrillin" EXACT []
is_obsolete: true
consider: GO:0001527
consider: GO:0005509

[Term]
id: GO:0001512
name: dihydronicotinamide riboside quinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [RHEA:12364]
synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" RELATED [EC:1.10.5.1]
synonym: "NQO2" RELATED [EC:1.10.5.1]
synonym: "NQO2 activity" RELATED [EC:1.10.5.1]
synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.5.1]
synonym: "QR2 activity" RELATED [EC:1.10.5.1]
synonym: "quinone reductase 2 activity" RELATED [EC:1.10.5.1]
synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT []
xref: EC:1.10.5.1
xref: MetaCyc:1.10.99.2-RXN
xref: Reactome:R-HSA-8936519 "NQO2:FAD dimer reduces quinones to hydroquinones"
xref: RHEA:12364
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0001514
name: selenocysteine incorporation
namespace: biological_process
def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022]
xref: RESID:AA0022
is_a: GO:0006451 ! translational readthrough

[Term]
id: GO:0001515
name: opioid peptide activity
namespace: molecular_function
def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732]
subset: goslim_chembl
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0001516
name: prostaglandin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai]
synonym: "prostaglandin anabolism" EXACT []
synonym: "prostaglandin biosynthesis" EXACT []
synonym: "prostaglandin formation" EXACT []
synonym: "prostaglandin synthesis" EXACT []
is_a: GO:0006693 ! prostaglandin metabolic process
is_a: GO:0046457 ! prostanoid biosynthetic process

[Term]
id: GO:0001517
name: N-acetylglucosamine 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd]
subset: goslim_chembl
synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT []
xref: Reactome:R-HSA-2046222 "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG"
xref: Reactome:R-HSA-3656269 "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG"
xref: Reactome:R-HSA-6786012 "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0001518
name: voltage-gated sodium channel complex
namespace: cellular_component
def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732]
synonym: "voltage gated sodium channel complex" EXACT []
synonym: "voltage-dependent sodium channel complex" EXACT []
synonym: "voltage-sensitive sodium channel complex" EXACT []
xref: NIF_Subcellular:sao785001660
is_a: GO:0034706 ! sodium channel complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0001519
name: peptide amidation
namespace: biological_process
def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916]
is_a: GO:0031179 ! peptide modification

[Term]
id: GO:0001520
name: outer dense fiber
namespace: cellular_component
def: "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins." [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759]
synonym: "outer dense fibre" EXACT []
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0036126 ! sperm flagellum

[Term]
id: GO:0001522
name: pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]
synonym: "pseudouridylation" EXACT []
xref: Wikipedia:Pseudouridine
xref: Wikipedia:Pseudouridylation
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0001523
name: retinoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732]
synonym: "retinoid metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process

[Term]
id: GO:0001524
name: obsolete globin
namespace: molecular_function
def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "globin" EXACT []
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0001525
name: angiogenesis
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym []
xref: Wikipedia:Angiogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001526
name: obsolete proteoglycan sulfate transfer
namespace: biological_process
def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd]
comment: This term was made obsolete because it represents a group of molecular functions.
synonym: "proteoglycan sulfate transfer" EXACT []
synonym: "proteoglycan sulphate transfer" EXACT []
is_obsolete: true
consider: GO:0006029
consider: GO:0006790
consider: GO:0050698

[Term]
id: GO:0001527
name: microfibril
namespace: cellular_component
def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [PMID:27026396]
synonym: "extended fibrils" EXACT []
synonym: "fibrillin" RELATED []
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0001528
name: obsolete elastin
namespace: molecular_function
def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "elastin" EXACT []
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001529
name: obsolete elastin
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "elastin" EXACT []
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001530
name: lipopolysaccharide binding
namespace: molecular_function
def: "Binding to a lipopolysaccharide." [PMID:11079463]
synonym: "endotoxin binding" BROAD []
synonym: "LPS binding" EXACT []
is_a: GO:0008289 ! lipid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0001531
name: interleukin-21 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-21 receptor." [GOC:ai]
synonym: "IL-21" NARROW []
synonym: "interleukin-21 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0001532
name: interleukin-21 receptor activity
namespace: molecular_function
def: "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-21 receptor activity" EXACT [GOC:mah]
synonym: "IL-21R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0001533
name: cornified envelope
namespace: cellular_component
def: "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139]
is_a: GO:0005886 ! plasma membrane

[Term]
id: GO:0001534
name: radial spoke
namespace: cellular_component
def: "Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [GOC:krc, ISBN:0124325653, PMID:22118931, PMID:25694453, PMID:34871179, PMID:9450971]
comment: Radial spokes are involved in some types of beating motions of the cilium. The radial spoke is usually a T-shaped structure comprised of a short base that attaches to the A-microtubule of an axonemal outer microtubule doublet (MTD) of a cilium, an elongated stalk, a neck complex, and an orthogonal head structure that extends perpendicularly towards the inner sheath and the central pair (CP) microtubules. Groups of radial spokes (RSs) repeat along the MTD with regular spacing. In most organisms, each group of radial spokes is comprised of a triplet of spokes: RS1, RS2, and RS3. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), each group contains a doublet of radial spokes: RS1 and RS2, while RS3 is represented only as a stump (referred to as RS3S) attached to the A-microtubule but lacking the rest of the stalk structure and entirely lacking the head structure. {xref="PMID:9450971", xref="GOC:krc", xref="PMID:34871179", xref="PMID:25694453"}
subset: goslim_pir
xref: Wikipedia:Radial_spoke
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0001535
name: radial spoke head
namespace: cellular_component
def: "Protein complex forming portion of the radial spoke that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary or flagellum axoneme." [GOC:cilia, GOC:hjd, GOC:krc, PMID:22754630, PMID:34871179]
synonym: "radial spokehead" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001536
name: radial spoke stalk
namespace: cellular_component
def: "Protein complex forming the elongated portion of the radial spoke between the base which binds to the A-tubule of each microtubule outer doublet and the neck which connects to the spoke head within the ciliary or flagellum axoneme." [GOC:hjd, GOC:krc, PMID:22754630, PMID:34871179]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001537
name: dermatan 4-sulfotransferase
namespace: molecular_function
def: "Catalysis of the reaction: n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H+." [RHEA:48052]
synonym: "N-acetylgalactosamine 4-O-sulfotransferase activity" RELATED []
synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" RELATED []
xref: EC:2.8.2.35
xref: Reactome:R-HSA-2022063 "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS"
xref: Reactome:R-HSA-3636919 "Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS"
xref: Reactome:R-HSA-6786034 "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin"
xref: RHEA:48052
is_a: GO:0050698 ! proteoglycan sulfotransferase activity

[Term]
id: GO:0001539
name: cilium or flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "ciliary or bacterial-type flagellar motility" RELATED []
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0001540
name: amyloid-beta binding
namespace: molecular_function
def: "Binding to an amyloid-beta peptide/protein." [GOC:hjd]
subset: goslim_chembl
synonym: "beta-amyloid binding" EXACT []
is_a: GO:0033218 ! amide binding
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0001541
name: ovarian follicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
synonym: "follicular phase" RELATED []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001542
name: ovulation from ovarian follicle
namespace: biological_process
def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0030728 ! ovulation
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001543
name: ovarian follicle rupture
namespace: biological_process
def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001542 ! ovulation from ovarian follicle

[Term]
id: GO:0001544
name: initiation of primordial ovarian follicle growth
namespace: biological_process
def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001545
name: primary ovarian follicle growth
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001546
name: preantral ovarian follicle growth
namespace: biological_process
def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001541 ! ovarian follicle development
relationship: part_of GO:0048162 ! multi-layer follicle stage

[Term]
id: GO:0001547
name: antral ovarian follicle growth
namespace: biological_process
def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001548
name: follicular fluid formation in ovarian follicle antrum
namespace: biological_process
def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT []
synonym: "ovarian follicle antrum/follicular fluid formation" EXACT []
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001547 ! antral ovarian follicle growth

[Term]
id: GO:0001549
name: cumulus cell differentiation
namespace: biological_process
def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [PMID:30010832]
synonym: "ovarian cumulus cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0001550
name: ovarian cumulus expansion
namespace: biological_process
def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [PMID:30010832]
synonym: "ovarian cumulus growth" RELATED []
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0001551
name: ovarian follicle endowment
namespace: biological_process
def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [PMID:30010832]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001552
name: ovarian follicle atresia
namespace: biological_process
def: "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed." [GOC:mtg_apoptosis, PMID:18638134]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001553
name: luteinization
namespace: biological_process
def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
synonym: "luteal phase" RELATED []
xref: Wikipedia:Luteal_phase
xref: Wikipedia:Luteinization
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001554
name: luteolysis
namespace: biological_process
def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [PMID:10617764]
xref: Wikipedia:Luteolysis
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001555
name: oocyte growth
namespace: biological_process
def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0001556
name: oocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
xref: Wikipedia:Oocyte_maturation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0001557
name: obsolete metabolic process resulting in cell growth
namespace: biological_process
def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph]
comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms.
synonym: "metabolic process resulting in cell growth" EXACT []
is_obsolete: true
consider: GO:0008152
consider: GO:0016049

[Term]
id: GO:0001558
name: regulation of cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0016049 ! cell growth

[Term]
id: GO:0001559
name: obsolete regulation of cell growth by detection of nuclear:cytoplasmic ratio
namespace: biological_process
def: "OBSOLETE. Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT []
synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT []
is_obsolete: true

[Term]
id: GO:0001560
name: regulation of cell growth by extracellular stimulus
namespace: biological_process
def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "interpretation of external signals that regulate cell growth" EXACT []
synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT []
synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT []
synonym: "regulation of growth by exogenous signal" EXACT []
synonym: "regulation of growth by exogenous stimuli" EXACT []
synonym: "regulation of growth by exogenous stimulus" EXACT []
synonym: "regulation of growth by external signal" EXACT []
synonym: "regulation of growth by external stimuli" EXACT []
synonym: "regulation of growth by external stimulus" EXACT []
is_a: GO:0001558 ! regulation of cell growth
relationship: part_of GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0001561
name: fatty acid alpha-oxidation
namespace: biological_process
def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [PMID:10198260]
xref: MetaCyc:PWY-2501
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0001562
name: response to protozoan
namespace: biological_process
alt_id: GO:0042833
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai]
synonym: "resistance to pathogenic protozoa" RELATED []
synonym: "response to protozoa" EXACT []
synonym: "response to protozoon" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0001563
name: detection of protozoan
namespace: biological_process
def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai]
synonym: "detection of protozoa" EXACT []
synonym: "detection of protozoon" EXACT []
synonym: "perception of protozoa" RELATED []
is_a: GO:0001562 ! response to protozoan
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0001564
name: obsolete resistance to pathogenic protozoa
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "resistance to pathogenic protozoa" EXACT []
is_obsolete: true
replaced_by: GO:0001562

[Term]
id: GO:0001565
name: phorbol ester receptor activity
namespace: molecular_function
def: "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:10506570]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0001566
name: non-kinase phorbol ester receptor activity
namespace: molecular_function
def: "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity." [PMID:10506570]
is_a: GO:0001565 ! phorbol ester receptor activity

[Term]
id: GO:0001567
name: cholesterol 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O." [RHEA:21104]
synonym: "cholesterol 25-monooxygenase activity" RELATED [EC:1.14.99.38]
synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" RELATED [EC:1.14.99.38]
xref: EC:1.14.99.38
xref: KEGG_REACTION:R07218
xref: MetaCyc:1.14.99.38-RXN
xref: RHEA:21104
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0001568
name: blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001569
name: branching involved in blood vessel morphogenesis
namespace: biological_process
def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph]
synonym: "patterning of blood vessels" BROAD [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
relationship: part_of GO:0001525 ! angiogenesis

[Term]
id: GO:0001570
name: vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798]
synonym: "vascular morphogenesis" EXACT []
xref: Wikipedia:Vasculogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001571
name: non-tyrosine kinase fibroblast growth factor receptor activity
namespace: molecular_function
def: "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity." [GOC:signaling, PMID:11418238]
synonym: "non-tyrosine kinase FGF receptor activity" EXACT []
synonym: "non-tyrosine kinase FGFR activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0001572
name: lactosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732, ISBN:0471586501]
synonym: "lactosylceramide anabolism" EXACT []
synonym: "lactosylceramide biosynthesis" EXACT []
synonym: "lactosylceramide formation" EXACT []
synonym: "lactosylceramide synthesis" EXACT []
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046478 ! lactosylceramide metabolic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0001573
name: ganglioside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732]
synonym: "ganglioside metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001574
name: ganglioside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732]
synonym: "ganglioside anabolism" EXACT []
synonym: "ganglioside biosynthesis" EXACT []
synonym: "ganglioside formation" EXACT []
synonym: "ganglioside synthesis" EXACT []
is_a: GO:0001573 ! ganglioside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0001575
name: globoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732]
synonym: "globoside metabolism" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001576
name: globoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I)." [ISBN:0198506732]
synonym: "globoside anabolism" EXACT []
synonym: "globoside biosynthesis" EXACT []
synonym: "globoside formation" EXACT []
synonym: "globoside synthesis" EXACT []
is_a: GO:0001575 ! globoside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process

[Term]
id: GO:0001577
name: obsolete galectin
namespace: molecular_function
def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "galectin" EXACT []
synonym: "S-type lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0016936

[Term]
id: GO:0001578
name: microtubule bundle formation
namespace: biological_process
def: "A process that results in a parallel arrangement of microtubules." [GOC:dph]
synonym: "microtubule bundling" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0001579
name: medium-chain fatty acid transport
namespace: biological_process
def: "The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [GOC:ai]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0001580
name: detection of chemical stimulus involved in sensory perception of bitter taste
namespace: biological_process
def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "bitter taste detection" EXACT []
synonym: "perception of bitter taste, detection of chemical stimulus" EXACT []
synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of bitter taste" EXACT []
synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT []
synonym: "sensory transduction of bitter taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050913 ! sensory perception of bitter taste

[Term]
id: GO:0001581
name: detection of chemical stimulus involved in sensory perception of sour taste
namespace: biological_process
def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sour taste, detection of chemical stimulus" EXACT []
synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory detection of sour taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory transduction of sour taste" EXACT []
synonym: "sour taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050915 ! sensory perception of sour taste

[Term]
id: GO:0001582
name: detection of chemical stimulus involved in sensory perception of sweet taste
namespace: biological_process
def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sweet taste, detection of chemical stimulus" EXACT []
synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory detection of sweet taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory transduction of sweet taste" EXACT []
synonym: "sweet taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050916 ! sensory perception of sweet taste

[Term]
id: GO:0001583
name: detection of chemical stimulus involved in sensory perception of salty taste
namespace: biological_process
def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of salty taste, detection of chemical stimulus" EXACT []
synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT []
synonym: "salty taste detection" EXACT []
synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory detection of salty taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory transduction of salty taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050914 ! sensory perception of salty taste

[Term]
id: GO:0001584
name: obsolete rhodopsin-like receptor activity
namespace: molecular_function
alt_id: GO:0001620
def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "Class A G protein coupled receptor" EXACT []
synonym: "Class A G-protein coupled receptor" EXACT []
synonym: "Class A GPCR" EXACT []
synonym: "class A orphan receptor activity" EXACT []
synonym: "rhodopsin-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001586
name: Gi/o-coupled serotonin receptor activity
namespace: molecular_function
def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247]
synonym: "5-HT1 receptor activity" EXACT [GOC:bf]
synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf]
is_a: GO:0004993 ! G protein-coupled serotonin receptor activity

[Term]
id: GO:0001587
name: Gq/11-coupled serotonin receptor activity
namespace: molecular_function
def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]
synonym: "5-HT2 receptor activity" BROAD [GOC:bf]
synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf]
is_a: GO:0004993 ! G protein-coupled serotonin receptor activity

[Term]
id: GO:0001588
name: dopamine neurotransmitter receptor activity, coupled via Gs
namespace: molecular_function
alt_id: GO:0001589
alt_id: GO:0001590
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260]
synonym: "dopamine D1 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D5 receptor activity" NARROW [GOC:bf]
is_a: GO:0004952 ! dopamine neurotransmitter receptor activity

[Term]
id: GO:0001591
name: dopamine neurotransmitter receptor activity, coupled via Gi/Go
namespace: molecular_function
alt_id: GO:0001592
alt_id: GO:0001593
alt_id: GO:0001670
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258]
synonym: "dopamine D2 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D3 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D4 receptor activity" NARROW [GOC:bf]
is_a: GO:0004952 ! dopamine neurotransmitter receptor activity

[Term]
id: GO:0001594
name: trace-amine receptor activity
namespace: molecular_function
def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074]
is_a: GO:0008227 ! G protein-coupled amine receptor activity

[Term]
id: GO:0001595
name: angiotensin receptor activity
namespace: molecular_function
def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0001596
name: angiotensin type I receptor activity
namespace: molecular_function
def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869]
synonym: "PLC-activating angiotensin receptor activity" EXACT [GOC:bf]
is_a: GO:0001595 ! angiotensin receptor activity

[Term]
id: GO:0001597
name: obsolete apelin-like receptor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because the function it represents does not exist.
synonym: "apelin-like receptor" EXACT []
synonym: "APJ-like receptor" EXACT []
is_obsolete: true
consider: GO:0031704

[Term]
id: GO:0001598
name: obsolete chemokine receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "chemokine receptor-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001601
name: peptide YY receptor activity
namespace: molecular_function
def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001602
name: pancreatic polypeptide receptor activity
namespace: molecular_function
def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001603
name: obsolete vasopressin-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators]
synonym: "vasopressin-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001604
name: urotensin II receptor activity
namespace: molecular_function
def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0001605
name: adrenomedullin receptor activity
namespace: molecular_function
def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai]
synonym: "G10D receptor" NARROW []
is_a: GO:0097642 ! calcitonin family receptor activity

[Term]
id: GO:0001606
name: obsolete GPR37/endothelin B-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "GPR37/endothelin B-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001607
name: neuromedin U receptor activity
namespace: molecular_function
def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
synonym: "NMUR activity" EXACT []
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0001608
name: G protein-coupled nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, IUPHAR_GPCR:1294]
synonym: "G protein coupled nucleotide receptor activity" EXACT []
synonym: "G-protein coupled nucleotide receptor activity" EXACT []
synonym: "nucleotide receptor activity, G protein coupled" EXACT []
synonym: "nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0001609
name: G protein-coupled adenosine receptor activity
namespace: molecular_function
alt_id: GO:0001610
alt_id: GO:0001611
alt_id: GO:0001612
alt_id: GO:0001613
alt_id: GO:0008501
def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]
synonym: "A1 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "adenosine nucleotide receptor" BROAD []
synonym: "adenosine receptor activity, G protein coupled" EXACT []
synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled A1 adenosine receptor activity" NARROW []
synonym: "G protein coupled A2A adenosine receptor activity" NARROW []
synonym: "G protein coupled A2B adenosine receptor activity" NARROW []
synonym: "G protein coupled A3 adenosine receptor activity" NARROW []
synonym: "G protein coupled adenosine receptor activity" EXACT []
synonym: "G-protein coupled adenosine receptor activity" EXACT []
synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW []
synonym: "P1 receptor" EXACT [PMID:9755289]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0001614
name: purinergic nucleotide receptor activity
namespace: molecular_function
alt_id: GO:0035586
def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "P2 receptor" RELATED [PMID:9755289]
synonym: "purinergic receptor activity" RELATED []
synonym: "purinoceptor" EXACT [PMID:9755289]
synonym: "purinoreceptor" EXACT [PMID:9755289]
is_a: GO:0016502 ! nucleotide receptor activity

[Term]
id: GO:0001615
name: obsolete thyrotropin releasing hormone and secretagogue-like receptors activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "thyrotropin releasing hormone and secretagogue-like receptors activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001616
name: growth hormone secretagogue receptor activity
namespace: molecular_function
def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853]
synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0001617
name: obsolete growth hormone secretagogue-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "growth hormone secretagogue-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001618
name: virus receptor activity
namespace: molecular_function
def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]
subset: goslim_chembl
subset: goslim_generic
synonym: "viral receptor activity" EXACT []
is_a: GO:0140272 ! exogenous protein binding

[Term]
id: GO:0001619
name: obsolete lysosphingolipid and lysophosphatidic acid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph]
synonym: "lysosphingolipid and lysophosphatidic acid receptor activity" EXACT []
is_obsolete: true
consider: GO:0038036
consider: GO:0070915

[Term]
id: GO:0001621
name: G protein-coupled ADP receptor activity
namespace: molecular_function
alt_id: GO:0045032
def: "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:11196645]
synonym: "ADP receptor activity" BROAD []
synonym: "ADP-activated adenosine receptor activity" RELATED []
synonym: "ADP-activated nucleotide receptor activity" BROAD []
synonym: "K101 receptor" NARROW []
synonym: "platelet ADP receptor activity" NARROW [GOC:mah]
is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity

[Term]
id: GO:0001626
name: nociceptin receptor activity
namespace: molecular_function
def: "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:18670432]
synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf]
synonym: "OFQ receptor activity" EXACT [PR:000012940]
synonym: "ORPH receptor" EXACT []
synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf]
synonym: "X-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! G protein-coupled opioid receptor activity
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0001627
name: obsolete leucine-rich G-protein receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "leucine-rich G protein receptor-like receptor activity" EXACT []
synonym: "leucine-rich G-protein receptor-like receptor activity" EXACT []
synonym: "LGR-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001628
name: obsolete gastropyloric receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the gastropyloric receptor is a type of neuron.
synonym: "gastropyloric receptor activity" EXACT []
synonym: "GPR receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001629
name: obsolete G-protein receptor 45-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "G protein receptor 45-like receptor activity" EXACT []
synonym: "G-protein receptor 45-like receptor activity" EXACT []
synonym: "GPR45-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001630
name: obsolete GP40-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "GP40-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001631
name: cysteinyl leukotriene receptor activity
namespace: molecular_function
def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732]
synonym: "CysLT receptor" EXACT []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001632
name: leukotriene B4 receptor activity
namespace: molecular_function
def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732]
synonym: "BLT receptor" NARROW []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001633
name: obsolete secretin-like receptor activity
namespace: molecular_function
alt_id: GO:0001638
def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "class B G protein coupled receptor" EXACT []
synonym: "class B G-protein coupled receptor" EXACT []
synonym: "class B GPCR" EXACT []
synonym: "class B orphan receptor activity" EXACT []
synonym: "secretin-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001634
name: pituitary adenylate cyclase-activating polypeptide receptor activity
namespace: molecular_function
alt_id: GO:0016522
def: "A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb]
synonym: "PACAP receptor" EXACT []
synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT []
synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb]
synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED []
synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0001635
name: calcitonin gene-related peptide receptor activity
namespace: molecular_function
def: "Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity." [GOC:mah, PMID:12037140]
synonym: "calcitonin gene-related polypeptide receptor activity" EXACT []
synonym: "CGRP receptor" EXACT []
xref: Wikipedia:CALCRL
is_a: GO:0097642 ! calcitonin family receptor activity

[Term]
id: GO:0001636
name: obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001637
name: G protein-coupled chemoattractant receptor activity
namespace: molecular_function
def: "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah]
synonym: "G protein chemoattractant receptor activity" EXACT []
synonym: "G-protein chemoattractant receptor activity" EXACT [GOC:bf]
synonym: "G-protein coupled chemoattractant receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0001639
name: PLC activating G protein-coupled glutamate receptor activity
namespace: molecular_function
def: "A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303]
synonym: "Group I metabotropic glutamate receptor" RELATED []
synonym: "group I metabotropic glutamate receptor activity" RELATED []
synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT []
synonym: "PLC activating G-protein coupled glutamate receptor activity" EXACT []
synonym: "PLC activating metabotropic glutamate receptor activity" EXACT [GOC:bf]
is_a: GO:0098988 ! G protein-coupled glutamate receptor activity

[Term]
id: GO:0001640
name: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph]
synonym: "adenylate cyclase inhibiting metabotropic glutamate receptor activity" RELATED [GOC:bf]
synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT []
is_a: GO:0098988 ! G protein-coupled glutamate receptor activity

[Term]
id: GO:0001641
name: group II metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph]
is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

[Term]
id: GO:0001642
name: group III metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303]
is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

[Term]
id: GO:0001646
name: cAMP receptor activity
namespace: molecular_function
alt_id: GO:0001644
def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:pg]
synonym: "3',5' cAMP receptor activity" EXACT []
synonym: "3',5'-cAMP receptor activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT []
synonym: "class E G protein coupled receptor" BROAD []
synonym: "class E G-protein coupled receptor" BROAD []
synonym: "class E GPCR" BROAD []
synonym: "cyclic AMP receptor activity" EXACT []
is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity

[Term]
id: GO:0001647
name: G protein-coupled cytokinin receptor activity
namespace: molecular_function
def: "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
synonym: "cytokinin receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled cytokinin receptor activity" EXACT []
synonym: "G-protein coupled cytokinin receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0009884 ! cytokinin receptor activity

[Term]
id: GO:0001648
name: proteinase-activated receptor activity
namespace: molecular_function
def: "A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it." [GOC:mah, PMID:11356985, PMID:33742547]
synonym: "protease-activated receptor activity" EXACT []
synonym: "proteinase activated receptor activity" EXACT []
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0001649
name: osteoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid]
synonym: "osteoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001503 ! ossification

[Term]
id: GO:0001650
name: fibrillar center
namespace: cellular_component
def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561]
synonym: "fibrillar centre" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0001651
name: dense fibrillar component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561]
synonym: "pars fibrosa" BROAD [NIF_Subcellular:sao1841764412]
xref: NIF_Subcellular:sao1841764412
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0001652
name: granular component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561]
synonym: "pars granulosa" BROAD [NIF_Subcellular:sao1217793903]
xref: NIF_Subcellular:sao1217793903
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0001653
name: peptide receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
synonym: "endogenous peptide receptor activity" NARROW []
synonym: "exogenous peptide receptor activity" NARROW []
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0001654
name: eye development
namespace: biological_process
alt_id: GO:0042460
def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
xref: Wikipedia:Eye_development
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0150063 ! visual system development

[Term]
id: GO:0001655
name: urogenital system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048731 ! system development

[Term]
id: GO:0001656
name: metanephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001657
name: ureteric bud development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0001658
name: branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378]
synonym: "ureteric bud branching" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0001659
name: temperature homeostasis
namespace: biological_process
def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl]
synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Thermoregulation
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0001660
name: fever generation
namespace: biological_process
def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl]
synonym: "pyrexia" BROAD []
xref: Wikipedia:Fever
is_a: GO:0006953 ! acute-phase response
is_a: GO:0031649 ! heat generation

[Term]
id: GO:0001661
name: conditioned taste aversion
namespace: biological_process
def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
xref: Wikipedia:Conditioned_taste_aversion
xref: Wikipedia:Taste_aversion
is_a: GO:0007631 ! feeding behavior
is_a: GO:0008306 ! associative learning

[Term]
id: GO:0001662
name: behavioral fear response
namespace: biological_process
def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659]
synonym: "behavioural fear response" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0042596 ! fear response

[Term]
id: GO:0001664
name: G protein-coupled receptor binding
namespace: molecular_function
def: "Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]
synonym: "G protein coupled receptor binding" EXACT []
synonym: "G protein coupled receptor ligand" NARROW []
synonym: "G-protein coupled receptor binding" EXACT [GOC:bf]
synonym: "G-protein-coupled receptor ligand" NARROW []
xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer"
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0001665
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.3.3]
synonym: "GalNAc alpha-2,6-sialyltransferase I activity" RELATED [EC:2.4.3.3]
xref: EC:2.4.3.3
xref: MetaCyc:2.4.99.3-RXN
xref: Reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)"
xref: Reactome:R-HSA-9603991 "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG"
xref: Reactome:R-HSA-9846305 "ST6GALNAC5,6 transfer Neu5Ac to GM1b"
xref: RHEA:11136
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0001666
name: response to hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "response to hypoxic stress" EXACT []
synonym: "response to intermittent hypoxia" NARROW []
synonym: "response to lowered oxygen tension" EXACT []
synonym: "response to sustained hypoxia" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0036293 ! response to decreased oxygen levels

[Term]
id: GO:0001667
name: ameboidal-type cell migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]
comment: Note that this term refers to a mode of migration rather than to any particular cell type.
synonym: "ameboid cell migration" EXACT []
synonym: "amoeboid cell migration" EXACT []
synonym: "amoeboidal cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0001669
name: acrosomal vesicle
namespace: cellular_component
def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]
synonym: "acrosomal granule" EXACT [GOC:sart]
synonym: "acrosome" EXACT [GOC:dph]
xref: Wikipedia:Acrosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0001671
name: ATPase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]
synonym: "ATPase stimulator activity" EXACT []
xref: Reactome:R-HSA-5251955 "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm"
xref: Reactome:R-HSA-5251959 "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol"
is_a: GO:0060590 ! ATPase regulator activity
is_a: GO:0140677 ! molecular function activator activity

[Term]
id: GO:0001673
name: male germ cell nucleus
namespace: cellular_component
alt_id: GO:0043081
def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
synonym: "male germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001674
name: female germ cell nucleus
namespace: cellular_component
alt_id: GO:0043080
def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd]
synonym: "female germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001675
name: acrosome assembly
namespace: biological_process
def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0001676
name: long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ajp]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0001677
name: formation of translation initiation ternary complex
namespace: biological_process
def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd]
synonym: "translation initiation ternary complex assembly" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001678
name: intracellular glucose homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "cellular glucose homeostasis" EXACT []
is_a: GO:0042593 ! glucose homeostasis
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0001680
name: tRNA 3'-terminal CCA addition
namespace: biological_process
def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." [GOC:go_curators, PMID:2247609]
is_a: GO:0042780 ! tRNA 3'-end processing

[Term]
id: GO:0001681
name: sialate O-acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039]
synonym: "N-acetylneuraminate acetyltransferase activity" RELATED []
xref: EC:3.1.1.53
is_a: GO:0008126 ! acetylesterase activity

[Term]
id: GO:0001682
name: tRNA 5'-leader removal
namespace: biological_process
def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395]
synonym: "tRNA 5' leader removal" EXACT []
is_a: GO:0099116 ! tRNA 5'-end processing

[Term]
id: GO:0001683
name: obsolete axonemal dynein heavy chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein heavy chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001684
name: obsolete axonemal dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein intermediate chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001685
name: obsolete axonemal dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein intermediate light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001686
name: obsolete axonemal dynein light chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001687
name: obsolete cytoplasmic dynein heavy chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein heavy chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001688
name: obsolete cytoplasmic dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein intermediate chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001689
name: obsolete cytoplasmic dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein intermediate light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001690
name: obsolete cytoplasmic dynein light chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001691
name: pseudophosphatase activity
namespace: molecular_function
def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp]
is_a: GO:0019212 ! phosphatase inhibitor activity

[Term]
id: GO:0001692
name: histamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine metabolism" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0001694
name: histamine biosynthetic process
namespace: biological_process
alt_id: GO:0001693
def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine anabolism" EXACT []
synonym: "histamine biosynthesis" EXACT []
synonym: "histamine formation" EXACT []
synonym: "histamine synthesis" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0042401 ! biogenic amine biosynthetic process

[Term]
id: GO:0001695
name: histamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine breakdown" EXACT []
synonym: "histamine catabolism" EXACT []
synonym: "histamine degradation" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0042402 ! biogenic amine catabolic process
is_a: GO:0052805 ! imidazole-containing compound catabolic process

[Term]
id: GO:0001696
name: gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd]
synonym: "hydrochloric acid secretion" NARROW []
is_a: GO:0022600 ! digestive system process
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0001697
name: histamine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001698
name: gastrin-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001699
name: acetylcholine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion
relationship: part_of GO:1905145 ! cellular response to acetylcholine

[Term]
id: GO:0001700
name: embryonic development via the syncytial blastoderm
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0001701
name: in utero embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001702
name: gastrulation with mouth forming second
namespace: biological_process
alt_id: GO:0010003
alt_id: GO:0048276
def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "deuterostomic gastrulation" EXACT [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001703
name: gastrulation with mouth forming first
namespace: biological_process
def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "protostomic gastrulation" NARROW [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001704
name: formation of primary germ layer
namespace: biological_process
def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0001705
name: ectoderm formation
namespace: biological_process
def: "The formation of ectoderm during gastrulation." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0001706
name: endoderm formation
namespace: biological_process
def: "The formation of the endoderm during gastrulation." [GOC:go_curators]
synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007492 ! endoderm development

[Term]
id: GO:0001707
name: mesoderm formation
namespace: biological_process
def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0048332 ! mesoderm morphogenesis

[Term]
id: GO:0001708
name: cell fate specification
namespace: biological_process
def: "The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate." [GOC:go_curators]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001709
name: cell fate determination
namespace: biological_process
def: "The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division." [ISBN:0878932437]
xref: Wikipedia:Cell_fate_determination
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001710
name: mesodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "mesoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0048333 ! mesodermal cell differentiation

[Term]
id: GO:0001711
name: endodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "endoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0035987 ! endodermal cell differentiation

[Term]
id: GO:0001712
name: ectodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0001705 ! ectoderm formation
relationship: part_of GO:0010668 ! ectodermal cell differentiation

[Term]
id: GO:0001713
name: ectodermal cell fate determination
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001714
name: endodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "endoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001711 ! endodermal cell fate commitment

[Term]
id: GO:0001715
name: ectodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "ectoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001716
name: L-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4+." [RHEA:13781]
synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.2]
synonym: "ophio-amino-acid oxidase activity" RELATED [EC:1.4.3.2]
xref: EC:1.4.3.2
xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN
xref: Reactome:R-HSA-2160492 "IL4I1:FAD oxidises L-Phe to kPPV"
xref: RHEA:13781
is_a: GO:0008131 ! primary methylamine oxidase activity

[Term]
id: GO:0001717
name: conversion of seryl-tRNAsec to selenocys-tRNAsec
namespace: biological_process
def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X]
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001720
name: conversion of lysyl-tRNA to pyrrolysyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639]
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001721
name: obsolete intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "IFAP" EXACT []
synonym: "intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001722
name: obsolete type I intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "type I intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001723
name: obsolete type II intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "type II intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001724
name: obsolete type III intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "type III intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0045098

[Term]
id: GO:0001725
name: stress fiber
namespace: cellular_component
def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]
synonym: "actin cable" RELATED [GOC:mah]
synonym: "stress fibre" EXACT []
is_a: GO:0042641 ! actomyosin
is_a: GO:0097517 ! contractile actin filament bundle

[Term]
id: GO:0001726
name: ruffle
namespace: cellular_component
def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
synonym: "membrane ruffle" RELATED []
is_a: GO:0120025 ! plasma membrane bounded cell projection
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0001727
name: lipid kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd]
xref: Reactome:R-HSA-428273 "SPHK1 phosphorylates sphingoid"
xref: Reactome:R-HSA-9695949 "SPHK2 phosphorylates sphingoid"
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0001729
name: ceramide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H+." [EC:2.7.1.138]
synonym: "acylsphingosine kinase activity" RELATED [EC:2.7.1.138]
synonym: "ATP:ceramide 1-phosphotransferase activity" RELATED [EC:2.7.1.138]
xref: EC:2.7.1.138
xref: MetaCyc:CERAMIDE-KINASE-RXN
xref: Reactome:R-HSA-1638845 "CERK phosphorylates CERA to form C1P"
xref: RHEA:17929
is_a: GO:0001727 ! lipid kinase activity

[Term]
id: GO:0001730
name: 2'-5'-oligoadenylate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732]
synonym: "(2-5')oligo(A) synthetase activity" EXACT []
synonym: "2'-5' oligoadenylate synthetase activity" EXACT []
synonym: "2-5A synthetase activity" EXACT []
synonym: "oligo-2',5'-adenylate synthetase activity" EXACT []
xref: EC:2.7.7.84
xref: MetaCyc:RXN-13648
xref: Reactome:R-HSA-8983680 "OAS1 produces oligoadenylates"
xref: Reactome:R-HSA-8985091 "OAS3 produces oligoadenylates"
xref: Reactome:R-HSA-8985104 "OAS2 produces oligoadenylates"
xref: RHEA:34407
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0001731
name: formation of translation preinitiation complex
namespace: biological_process
def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children.
synonym: "formation of translation pre-initiation complex" EXACT []
synonym: "translation preinitiation complex assembly" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:0001732
name: formation of cytoplasmic translation initiation complex
namespace: biological_process
def: "Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, PMID:29735639]
synonym: "cytoplasmic translation initiation complex assembly" EXACT []
synonym: "formation of translation initiation complex" BROAD []
synonym: "translation initiation complex assembly" BROAD []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:0001733
name: galactosylceramide sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929, RHEA:20613]
synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" RELATED [EC:2.8.2.11]
synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" RELATED [EC:2.8.2.11]
synonym: "cerebroside sulfotransferase activity" EXACT []
synonym: "galactocerebroside sulfotransferase activity" RELATED [EC:2.8.2.11]
synonym: "galactolipid sulfotransferase activity" RELATED [EC:2.8.2.11]
synonym: "galactosylceramide sulphotransferase activity" EXACT []
synonym: "glycolipid sulfotransferase activity" RELATED [EC:2.8.2.11]
synonym: "glycosphingolipid sulfotransferase activity" RELATED [EC:2.8.2.11]
synonym: "GSase" RELATED [EC:2.8.2.11]
xref: EC:2.8.2.11
xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-9844587 "GAL3ST1 transfers sulfate to GalCer,LacCer"
xref: RHEA:20613
is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity

[Term]
id: GO:0001734
name: mRNA m(6)A methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U." [EC:2.1.1.348, GOC:hjd]
synonym: "mRNA (N6-adenosine)-methyltransferase activity" EXACT []
xref: EC:2.1.1.348
xref: MetaCyc:RXN-19346
xref: Reactome:R-HSA-72095 "Internal Methylation of mRNA"
xref: RHEA:55584
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0001735
name: prenylcysteine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd, RHEA:53892]
synonym: "prenylcysteine lyase activity" RELATED [EC:1.8.3.5]
synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" RELATED [EC:1.8.3.5]
xref: EC:1.8.3.5
xref: MetaCyc:RXN-18932
xref: RHEA:53892
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0001736
name: establishment of planar polarity
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
synonym: "establishment of planar cell polarity" NARROW []
is_a: GO:0007164 ! establishment of tissue polarity
relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium

[Term]
id: GO:0001737
name: establishment of imaginal disc-derived wing hair orientation
namespace: biological_process
def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
synonym: "establishment of wing hair orientation" EXACT []
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0001738
name: morphogenesis of a polarized epithelium
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
synonym: "epithelial polarization" EXACT [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0001739
name: sex chromatin
namespace: cellular_component
def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732]
is_a: GO:0000792 ! heterochromatin
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0001740
name: Barr body
namespace: cellular_component
def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, NIF_Subcellular:sao1571698684]
xref: NIF_Subcellular:sao1571698684
xref: Wikipedia:Barr_body
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000805 ! X chromosome

[Term]
id: GO:0001741
name: XY body
namespace: cellular_component
def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, PMID:20622855, Wikipedia:XY_sex-determination_system]
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0001742
name: oenocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators]
synonym: "oenocyte cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0001743
name: lens placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph]
synonym: "optic placode formation" RELATED []
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0001744
name: insect visual primordium formation
namespace: biological_process
alt_id: GO:0007457
def: "Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor formation" EXACT []
synonym: "optic lobe placode formation" EXACT []
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0001748 ! insect visual primordium development

[Term]
id: GO:0001745
name: compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0001746
name: Bolwig's organ morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [PMID:6185380]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0055034 ! Bolwig's organ development

[Term]
id: GO:0001748
name: insect visual primordium development
namespace: biological_process
alt_id: GO:0048049
def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor development" EXACT []
synonym: "optic lobe placode development" EXACT []
synonym: "optic placode development" BROAD []
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0001750
name: photoreceptor outer segment
namespace: cellular_component
def: "The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins." [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097733 ! photoreceptor cell cilium

[Term]
id: GO:0001751
name: compound eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0001752
name: compound eye photoreceptor fate commitment
namespace: biological_process
alt_id: GO:0007459
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0042706 ! eye photoreceptor cell fate commitment
relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0001753
name: obsolete adult eye photoreceptor development (sensu Drosophila)
namespace: biological_process
def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators]
comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins.
synonym: "adult eye photoreceptor development (sensu Drosophila)" EXACT []
is_obsolete: true
consider: GO:0042051

[Term]
id: GO:0001754
name: eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0001755
name: neural crest cell migration
namespace: biological_process
def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
is_a: GO:0090497 ! mesenchymal cell migration
relationship: part_of GO:0014032 ! neural crest cell development

[Term]
id: GO:0001756
name: somitogenesis
namespace: biological_process
def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]
synonym: "formation of mesodermal clusters" EXACT systematic_synonym []
xref: Wikipedia:Somitogenesis
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0035282 ! segmentation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: part_of GO:0061053 ! somite development

[Term]
id: GO:0001757
name: somite specification
namespace: biological_process
def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph]
is_a: GO:0007379 ! segment specification
is_a: GO:0009880 ! embryonic pattern specification
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0001758
name: retinal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36]
synonym: "cytosolic retinal dehydrogenase activity" RELATED [EC:1.2.1.36]
synonym: "retinal:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.36]
xref: EC:1.2.1.36
xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-5362522 "ALDHs oxidise atRAL to atRA"
xref: Reactome:R-HSA-5696101 "ALDH8A1 oxidises 9cRAL to 9cRA"
xref: RHEA:16177
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0001759
name: organ induction
namespace: biological_process
def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437]
synonym: "induction of an organ" EXACT []
is_a: GO:0003156 ! regulation of animal organ formation
is_a: GO:0031128 ! developmental induction
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
relationship: positively_regulates GO:0010092 ! specification of animal organ identity

[Term]
id: GO:0001760
name: aminocarboxymuconate-semialdehyde decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2." [EC:4.1.1.45, RHEA:16557]
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" RELATED [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" RELATED [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" RELATED [EC:4.1.1.45]
synonym: "ACMSD activity" EXACT [PMID:17288562]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" RELATED [EC:4.1.1.45]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" RELATED [EC:4.1.1.45]
synonym: "picolinic acid carboxylase activity" RELATED [EC:4.1.1.45]
synonym: "picolinic acid decarboxylase activity" RELATED [EC:4.1.1.45]
xref: EC:4.1.1.45
xref: KEGG_REACTION:R04323
xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN
xref: RHEA:16557
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0001761
name: beta-alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd]
synonym: "beta-alanine transporter activity" BROAD []
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0001762
name: beta-alanine transport
namespace: biological_process
def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0001763
name: morphogenesis of a branching structure
namespace: biological_process
def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
synonym: "branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001764
name: neuron migration
namespace: biological_process
def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
synonym: "neuron chemotaxis" EXACT []
synonym: "neuron guidance" RELATED []
synonym: "neuronal migration" EXACT []
xref: Wikipedia:Neural_development#Neuron_migration
xref: Wikipedia:Neuron_migration
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0001765
name: membrane raft assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198]
synonym: "lipid raft assembly" EXACT [GOC:mah]
synonym: "lipid raft formation" RELATED []
synonym: "membrane raft formation" RELATED [GOC:mah]
is_a: GO:0031579 ! membrane raft organization
is_a: GO:0071709 ! membrane assembly

[Term]
id: GO:0001766
name: membrane raft polarization
namespace: biological_process
def: "The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [PMID:12615889]
synonym: "lipid raft polarization" EXACT []
synonym: "membrane polarization" EXACT []
is_a: GO:0031580 ! membrane raft distribution

[Term]
id: GO:0001767
name: establishment of lymphocyte polarity
namespace: biological_process
def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "lymphocyte polarization" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001768
name: establishment of T cell polarity
namespace: biological_process
def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "establishment of T lymphocyte polarity" EXACT []
synonym: "establishment of T-cell polarity" EXACT []
synonym: "establishment of T-lymphocyte polarity" EXACT []
synonym: "T cell polarization" EXACT []
synonym: "T lymphocyte polarization" EXACT []
synonym: "T-cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042110 ! T cell activation

[Term]
id: GO:0001769
name: establishment of B cell polarity
namespace: biological_process
def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889]
comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells.
synonym: "B cell polarization" EXACT []
synonym: "B lymphocyte polarization" EXACT []
synonym: "B-cell polarization" EXACT []
synonym: "establishment of B lymphocyte polarity" EXACT []
synonym: "establishment of B-cell polarity" EXACT []
synonym: "establishment of B-lymphocyte polarity" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042113 ! B cell activation

[Term]
id: GO:0001770
name: establishment of natural killer cell polarity
namespace: biological_process
def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849]
synonym: "establishment of NK cell polarity" EXACT []
synonym: "natural killer cell polarization" EXACT []
synonym: "NK cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001771
name: immunological synapse formation
namespace: biological_process
def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330]
synonym: "formation of immunological synapse" EXACT []
is_a: GO:0009988 ! cell-cell recognition
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001772
name: immunological synapse
namespace: cellular_component
def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300]
synonym: "c-SMAC" NARROW [PMID:14724296]
synonym: "supramolecular activation cluster" EXACT [PMID:14724296]
xref: Wikipedia:Immunological_synapse
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0001773
name: myeloid dendritic cell activation
namespace: biological_process
def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0001774
name: microglial cell activation
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
is_a: GO:0002269 ! leukocyte activation involved in inflammatory response
is_a: GO:0042116 ! macrophage activation
is_a: GO:0061900 ! glial cell activation

[Term]
id: GO:0001775
name: cell activation
namespace: biological_process
def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001776
name: leukocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
synonym: "immune cell homeostasis" EXACT []
synonym: "leucocyte homeostasis" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0001777
name: T cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149]
synonym: "resting T cell proliferation" EXACT []
synonym: "resting T-cell proliferation" EXACT []
synonym: "T lymphocyte homeostatic proliferation" EXACT []
synonym: "T-cell homeostatic proliferation" EXACT []
synonym: "T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0001778
name: plasma membrane repair
namespace: biological_process
def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0001779
name: natural killer cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development" RELATED [GOC:add]
synonym: "NK cell differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001780
name: neutrophil homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266]
comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0001781
name: neutrophil apoptotic process
namespace: biological_process
def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266]
synonym: "apoptosis of neutrophils" EXACT []
synonym: "neutrophil apoptosis" NARROW []
synonym: "neutrophil programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neutrophils by apoptosis" EXACT []
synonym: "programmed cell death, neutrophils" EXACT []
is_a: GO:0006925 ! inflammatory cell apoptotic process
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process
relationship: part_of GO:0001780 ! neutrophil homeostasis

[Term]
id: GO:0001782
name: B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429]
comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B lymphocyte homeostasis" EXACT []
synonym: "B-cell homeostasis" EXACT []
synonym: "B-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0001783
name: B cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of B cells" EXACT []
synonym: "apoptosis of B lymphocytes" EXACT []
synonym: "apoptosis of B-cells" EXACT []
synonym: "apoptosis of B-lymphocytes" EXACT []
synonym: "B cell apoptosis" NARROW []
synonym: "B cell programmed cell death by apoptosis" EXACT []
synonym: "B lymphocyte apoptosis" EXACT []
synonym: "B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "B-cell apoptosis" EXACT []
synonym: "B-cell programmed cell death by apoptosis" EXACT []
synonym: "B-lymphocyte apoptosis" EXACT []
synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of B cells by apoptosis" EXACT []
synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of B-cells by apoptosis" EXACT []
synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, B cells" EXACT []
synonym: "programmed cell death, B lymphocytes" EXACT []
synonym: "programmed cell death, B-cells" EXACT []
synonym: "programmed cell death, B-lymphocytes" EXACT []
is_a: GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0001784
name: phosphotyrosine residue binding
namespace: molecular_function
def: "Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584]
synonym: "phosphotyrosine binding" RELATED []
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0001785
name: prostaglandin J receptor activity
namespace: molecular_function
def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180]
synonym: "PGJ receptor activity" RELATED []
synonym: "PGJ(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0001786
name: phosphatidylserine binding
namespace: molecular_function
def: "Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0072341 ! modified amino acid binding

[Term]
id: GO:0001787
name: natural killer cell proliferation
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149]
synonym: "NK cell proliferation" EXACT []
is_a: GO:0030101 ! natural killer cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0001788
name: antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [GOC:pr, ISBN:0781735149, PMID:11677095, PMID:9581795]
synonym: "ADCC" EXACT []
synonym: "antibody dependent cell death" EXACT []
synonym: "antibody dependent cell killing" EXACT []
synonym: "antibody-dependent cell death" EXACT []
synonym: "antibody-dependent cell killing" EXACT []
synonym: "type VI hypersensitivity" EXACT []
xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity
xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity
is_a: GO:0001794 ! type IIa hypersensitivity
is_a: GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001790
name: polymeric immunoglobulin binding
namespace: molecular_function
def: "Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001791
name: IgM binding
namespace: molecular_function
def: "Binding to an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001792
name: polymeric immunoglobulin receptor activity
namespace: molecular_function
def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity

[Term]
id: GO:0001793
name: IgM receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity

[Term]
id: GO:0001794
name: type IIa hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149]
comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity.
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001795
name: type IIb hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149]
comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity.
synonym: "type V hypersensitivity" EXACT []
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001796
name: regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001797
name: negative regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IIa hypersensitivity" EXACT []
synonym: "down-regulation of type IIa hypersensitivity" EXACT []
synonym: "downregulation of type IIa hypersensitivity" EXACT []
synonym: "inhibition of type IIa hypersensitivity" NARROW []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001798
name: positive regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IIa hypersensitivity" NARROW []
synonym: "stimulation of type IIa hypersensitivity" NARROW []
synonym: "up regulation of type IIa hypersensitivity" EXACT []
synonym: "up-regulation of type IIa hypersensitivity" EXACT []
synonym: "upregulation of type IIa hypersensitivity" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001799
name: regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001800
name: negative regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IIb hypersensitivity" EXACT []
synonym: "down-regulation of type IIb hypersensitivity" EXACT []
synonym: "downregulation of type IIb hypersensitivity" EXACT []
synonym: "inhibition of type IIb hypersensitivity" NARROW []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001801
name: positive regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IIb hypersensitivity" NARROW []
synonym: "stimulation of type IIb hypersensitivity" NARROW []
synonym: "up regulation of type IIb hypersensitivity" EXACT []
synonym: "up-regulation of type IIb hypersensitivity" EXACT []
synonym: "upregulation of type IIb hypersensitivity" EXACT []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001802
name: type III hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149]
comment: Note that the Arthus reaction is an example of type III hypersensitivity.
xref: Wikipedia:Type_III_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0001803
name: regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001804
name: negative regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type III hypersensitivity" EXACT []
synonym: "down-regulation of type III hypersensitivity" EXACT []
synonym: "downregulation of type III hypersensitivity" EXACT []
synonym: "inhibition of type III hypersensitivity" NARROW []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
relationship: negatively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001805
name: positive regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type III hypersensitivity" NARROW []
synonym: "stimulation of type III hypersensitivity" NARROW []
synonym: "up regulation of type III hypersensitivity" EXACT []
synonym: "up-regulation of type III hypersensitivity" EXACT []
synonym: "upregulation of type III hypersensitivity" EXACT []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
relationship: positively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001806
name: type IV hypersensitivity
namespace: biological_process
alt_id: GO:0016069
def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149]
synonym: "delayed hypersensitivity response" EXACT []
synonym: "delayed-type hypersensitivity" EXACT []
xref: Wikipedia:Type_IV_hypersensitivity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002524 ! hypersensitivity

[Term]
id: GO:0001807
name: regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002883 ! regulation of hypersensitivity
relationship: regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001808
name: negative regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IV hypersensitivity" EXACT []
synonym: "down-regulation of type IV hypersensitivity" EXACT []
synonym: "downregulation of type IV hypersensitivity" EXACT []
synonym: "inhibition of type IV hypersensitivity" NARROW []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002884 ! negative regulation of hypersensitivity
relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001809
name: positive regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IV hypersensitivity" NARROW []
synonym: "stimulation of type IV hypersensitivity" NARROW []
synonym: "up regulation of type IV hypersensitivity" EXACT []
synonym: "up-regulation of type IV hypersensitivity" EXACT []
synonym: "upregulation of type IV hypersensitivity" EXACT []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002885 ! positive regulation of hypersensitivity
relationship: positively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001810
name: regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001811
name: negative regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type I hypersensitivity" EXACT []
synonym: "down-regulation of type I hypersensitivity" EXACT []
synonym: "downregulation of type I hypersensitivity" EXACT []
synonym: "inhibition of type I hypersensitivity" NARROW []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
relationship: negatively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001812
name: positive regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type I hypersensitivity" NARROW []
synonym: "stimulation of type I hypersensitivity" NARROW []
synonym: "up regulation of type I hypersensitivity" EXACT []
synonym: "up-regulation of type I hypersensitivity" EXACT []
synonym: "upregulation of type I hypersensitivity" EXACT []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
relationship: positively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001813
name: regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of antibody dependent cell death" EXACT []
synonym: "regulation of antibody dependent cell killing" EXACT []
synonym: "regulation of antibody-dependent cell death" EXACT []
synonym: "regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001814
name: negative regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "negative regulation of antibody dependent cell death" EXACT []
synonym: "negative regulation of antibody dependent cell killing" EXACT []
synonym: "negative regulation of antibody-dependent cell death" EXACT []
synonym: "negative regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001815
name: positive regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "positive regulation of antibody dependent cell death" EXACT []
synonym: "positive regulation of antibody dependent cell killing" EXACT []
synonym: "positive regulation of antibody-dependent cell death" EXACT []
synonym: "positive regulation of antibody-dependent cell killing" EXACT []
synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT []
is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
alt_id: GO:0042032
alt_id: GO:0042089
alt_id: GO:0042107
alt_id: GO:0050663
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cytokine biosynthetic process" NARROW []
synonym: "cytokine metabolic process" NARROW []
synonym: "cytokine secretion" NARROW []
synonym: "interferon production" NARROW [GOC:add, GOC:mah]
synonym: "interferon secretion" NARROW [GOC:add, GOC:mah]
synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
is_a: GO:0010467 ! gene expression
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001817
name: regulation of cytokine production
namespace: biological_process
alt_id: GO:0042035
alt_id: GO:0050707
def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "regulation of cytokine anabolism" EXACT []
synonym: "regulation of cytokine biosynthesis" EXACT []
synonym: "regulation of cytokine biosynthetic process" NARROW []
synonym: "regulation of cytokine formation" EXACT []
synonym: "regulation of cytokine secretion" NARROW []
synonym: "regulation of cytokine synthesis" EXACT []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001818
name: negative regulation of cytokine production
namespace: biological_process
alt_id: GO:0042036
alt_id: GO:0050710
def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "down regulation of cytokine biosynthetic process" EXACT []
synonym: "down regulation of cytokine production" EXACT []
synonym: "down-regulation of cytokine biosynthetic process" EXACT []
synonym: "down-regulation of cytokine production" EXACT []
synonym: "downregulation of cytokine biosynthetic process" EXACT []
synonym: "downregulation of cytokine production" EXACT []
synonym: "inhibition of cytokine biosynthetic process" NARROW []
synonym: "inhibition of cytokine production" NARROW []
synonym: "negative regulation of cytokine anabolism" EXACT []
synonym: "negative regulation of cytokine biosynthesis" EXACT []
synonym: "negative regulation of cytokine biosynthetic process" NARROW []
synonym: "negative regulation of cytokine formation" EXACT []
synonym: "negative regulation of cytokine secretion" NARROW []
synonym: "negative regulation of cytokine synthesis" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001819
name: positive regulation of cytokine production
namespace: biological_process
alt_id: GO:0042108
alt_id: GO:0050715
def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "activation of cytokine production" NARROW []
synonym: "positive regulation of cytokine biosynthetic process" NARROW []
synonym: "positive regulation of cytokine secretion" NARROW []
synonym: "stimulation of cytokine production" NARROW []
synonym: "up regulation of cytokine production" EXACT []
synonym: "up-regulation of cytokine production" EXACT []
synonym: "upregulation of cytokine production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001820
name: serotonin secretion
namespace: biological_process
def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149]
synonym: "5-HT secretion" EXACT []
synonym: "5-hydroxytryptamine secretion" EXACT []
synonym: "serotonin release" RELATED [GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0001821
name: histamine secretion
namespace: biological_process
def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149]
is_a: GO:0046903 ! secretion
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0001822
name: kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
synonym: "nephrogenesis" RELATED [GOC:rph]
xref: Wikipedia:Kidney_development
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0001823
name: mesonephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]
synonym: "Wolffian body development" EXACT [GOC:dph]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001824
name: blastocyst development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
synonym: "blastula development" RELATED []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001701 ! in utero embryonic development

[Term]
id: GO:0001825
name: blastocyst formation
namespace: biological_process
def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
synonym: "blastula formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001826
name: inner cell mass cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001827
name: inner cell mass cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001828
name: inner cell mass cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001829
name: trophectodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001830
name: trophectodermal cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell fate commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001831
name: trophectodermal cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cellular morphogenesis" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001832
name: blastocyst growth
namespace: biological_process
def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
synonym: "blastula growth" RELATED []
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001833
name: inner cell mass cell proliferation
namespace: biological_process
def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001834
name: trophectodermal cell proliferation
namespace: biological_process
def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cell proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001835
name: blastocyst hatching
namespace: biological_process
def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'.
synonym: "blastula hatching" RELATED []
is_a: GO:0035188 ! hatching
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001836
name: release of cytochrome c from mitochondria
namespace: biological_process
def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.
is_a: GO:0008637 ! apoptotic mitochondrial changes
relationship: part_of GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0001837
name: epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]
synonym: "EMT" EXACT []
synonym: "epithelial-mesenchymal transition" EXACT []
synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl]
is_a: GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0001838
name: embryonic epithelial tube formation
namespace: biological_process
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium

[Term]
id: GO:0001839
name: neural plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001840 ! neural plate development

[Term]
id: GO:0001840
name: neural plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001841
name: neural tube formation
namespace: biological_process
alt_id: GO:0001679
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]
synonym: "neural tube morphogenesis" EXACT [GOC:dph]
synonym: "neurulation" EXACT []
xref: Wikipedia:Neurulation
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0001842
name: neural fold formation
namespace: biological_process
def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]
synonym: "neural groove formation" RELATED [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001843
name: neural tube closure
namespace: biological_process
def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001844
name: obsolete protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
namespace: biological_process
def: "OBSOLETE. The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway." [GOC:add, GOC:mtg_apoptosis, PMID:12952892]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW []
synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:dph, GOC:tb]
synonym: "protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW []
synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" NARROW []
is_obsolete: true
consider: GO:0051204

[Term]
id: GO:0001845
name: phagolysosome assembly
namespace: biological_process
def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149]
synonym: "late phagosome biosynthesis" RELATED []
synonym: "late phagosome formation" RELATED []
synonym: "phagolysosome formation" RELATED [GOC:mah]
is_a: GO:0007040 ! lysosome organization
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0090382 ! phagosome maturation

[Term]
id: GO:0001846
name: opsonin binding
namespace: molecular_function
def: "Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149]
comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001847
name: opsonin receptor activity
namespace: molecular_function
def: "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0001848
name: complement binding
namespace: molecular_function
def: "Binding to a component or product of the complement cascade." [GOC:add, ISBN:0781735149]
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001849
name: complement component C1q complex binding
namespace: molecular_function
def: "Binding to a C1q complex, a component of the classical complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0001850
name: complement component C3a binding
namespace: molecular_function
def: "Binding to a C3a product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001851
name: complement component C3b binding
namespace: molecular_function
def: "Binding to a C3b product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001852
name: complement component iC3b binding
namespace: molecular_function
def: "Binding to a iC3b product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001853
name: complement component C3dg binding
namespace: molecular_function
def: "Binding to a C3dg product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001854
name: complement component C3d binding
namespace: molecular_function
def: "Binding to a C3d product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001855
name: complement component C4b binding
namespace: molecular_function
def: "Binding to a C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001856
name: complement component C5a binding
namespace: molecular_function
def: "Binding to a C5a product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001857
name: complement component C1q receptor activity
namespace: molecular_function
def: "Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001858
name: complement component iC3b receptor activity
namespace: molecular_function
def: "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001859
name: complement component C3dg receptor activity
namespace: molecular_function
def: "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001860
name: complement component C3d receptor activity
namespace: molecular_function
def: "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001861
name: complement component C4b receptor activity
namespace: molecular_function
def: "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001862
name: collectin binding
namespace: molecular_function
def: "Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149]
comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001863
name: collectin receptor activity
namespace: molecular_function
def: "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001847 ! opsonin receptor activity

[Term]
id: GO:0001864
name: pentraxin binding
namespace: molecular_function
def: "Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149]
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001865
name: NK T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer T cell differentiation" EXACT []
synonym: "natural T cell differentiation" EXACT []
synonym: "NK T cell development" RELATED [GOC:add]
synonym: "NK T lymphocyte differentiation" EXACT []
synonym: "NK T-cell differentiation" EXACT []
synonym: "NK T-lymphocyte differentiation" EXACT []
synonym: "NKT cell differentiation" EXACT []
synonym: "NT cell differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0001866
name: NK T cell proliferation
namespace: biological_process
def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
synonym: "natural killer T cell proliferation" EXACT []
synonym: "natural T cell proliferation" EXACT []
synonym: "NK T lymphocyte proliferation" EXACT []
synonym: "NK T-cell proliferation" EXACT []
synonym: "NK T-lymphocyte proliferation" EXACT []
synonym: "NKT cell proliferation" EXACT []
synonym: "NT cell proliferation" EXACT []
is_a: GO:0046633 ! alpha-beta T cell proliferation
is_a: GO:0051132 ! NK T cell activation

[Term]
id: GO:0001867
name: complement activation, lectin pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149]
comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
synonym: "complement cascade, lectin pathway" EXACT [GOC:add]
is_a: GO:0006956 ! complement activation
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0001868
name: regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149]
synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add]
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001869
name: negative regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]
synonym: "down regulation of complement activation, lectin pathway" EXACT []
synonym: "down-regulation of complement activation, lectin pathway" EXACT []
synonym: "downregulation of complement activation, lectin pathway" EXACT []
synonym: "inhibition of complement activation, lectin pathway" NARROW []
synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add]
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001870
name: positive regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]
synonym: "activation of complement activation, lectin pathway" NARROW []
synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add]
synonym: "stimulation of complement activation, lectin pathway" NARROW []
synonym: "up regulation of complement activation, lectin pathway" EXACT []
synonym: "up-regulation of complement activation, lectin pathway" EXACT []
synonym: "upregulation of complement activation, lectin pathway" EXACT []
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001871
name: obsolete pattern binding
namespace: molecular_function
def: "OBSOLETE. Binding to a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544]
comment: This term was obsoleted because it was an unnecessary grouping term.
synonym: "pattern recognition activity" BROAD []
is_obsolete: true

[Term]
id: GO:0001872
name: (1->3)-beta-D-glucan binding
namespace: molecular_function
alt_id: GO:0080087
def: "Binding to a (1->3)-beta-D-glucan." [PMID:14707091]
synonym: "1,3-beta-D-glucan binding" EXACT []
synonym: "callose binding" NARROW []
synonym: "zymosan binding" NARROW [GOC:tb]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0001873
name: polysaccharide immune receptor activity
namespace: molecular_function
def: "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:14707091]
synonym: "polysaccharide receptor activity" BROAD []
is_a: GO:0038187 ! pattern recognition receptor activity

[Term]
id: GO:0001874
name: (1->3)-beta-D-glucan immune receptor activity
namespace: molecular_function
def: "Combining with (1->3)-beta-D-glucans to initiate an innate immune response." [PMID:14707091]
synonym: "(1,3)-beta-D-glucan receptor activity" EXACT []
synonym: "(1->3)-beta-D-glucan receptor activity" BROAD []
synonym: "1,3-beta-D-glucan receptor activity" EXACT []
synonym: "beta-1,3-D-glucan receptor activity" EXACT []
synonym: "zymosan receptor activity" NARROW [GOC:tb]
is_a: GO:0001873 ! polysaccharide immune receptor activity

[Term]
id: GO:0001875
name: lipopolysaccharide immune receptor activity
namespace: molecular_function
def: "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975]
synonym: "endotoxin receptor activity" BROAD []
synonym: "lipopolysaccharide receptor activity" BROAD []
synonym: "LPS receptor activity" EXACT []
is_a: GO:0038187 ! pattern recognition receptor activity

[Term]
id: GO:0001876
name: lipoarabinomannan binding
namespace: molecular_function
def: "Binding to lipoarabinomannan." [PMID:10586073]
synonym: "LAM binding" EXACT []
is_a: GO:0034235 ! GPI anchor binding

[Term]
id: GO:0001877
name: lipoarabinomannan immune receptor activity
namespace: molecular_function
def: "Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response." [PMID:10586073]
synonym: "LAM receptor activity" EXACT []
synonym: "lipoarabinomannan receptor activity" BROAD []
is_a: GO:0038187 ! pattern recognition receptor activity

[Term]
id: GO:0001878
name: response to yeast
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091]
comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast.
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0001879
name: detection of yeast
namespace: biological_process
def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091]
is_a: GO:0001878 ! response to yeast
is_a: GO:0016046 ! detection of fungus

[Term]
id: GO:0001880
name: Mullerian duct regression
namespace: biological_process
def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0001881
name: receptor recycling
namespace: biological_process
def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0001882
name: nucleoside binding
namespace: molecular_function
def: "Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]
subset: goslim_pir
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097367 ! carbohydrate derivative binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0001883
name: purine nucleoside binding
namespace: molecular_function
def: "Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001884
name: pyrimidine nucleoside binding
namespace: molecular_function
def: "Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001885
name: endothelial cell development
namespace: biological_process
def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0001886
name: endothelial cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
relationship: part_of GO:0001885 ! endothelial cell development

[Term]
id: GO:0001887
name: selenium compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456]
synonym: "selenium compound metabolism" EXACT []
synonym: "selenium metabolic process" EXACT []
synonym: "selenium metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0001888
name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H+ + UDP." [EC:2.4.1.223, RHEA:16221]
synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.223]
synonym: "alpha-N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.223]
synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.223]
synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.223]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.223]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.223]
xref: EC:2.4.1.223
xref: MetaCyc:2.4.1.223-RXN
xref: RHEA:16221
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0001889
name: liver development
namespace: biological_process
def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0001890
name: placenta development
namespace: biological_process
def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "placental development" EXACT []
synonym: "placentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0001891
name: phagocytic cup
namespace: cellular_component
def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0001892
name: embryonic placenta development
namespace: biological_process
def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "fetal placenta development" EXACT [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001893
name: maternal placenta development
namespace: biological_process
def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "decidua development" RELATED [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0060135 ! maternal process involved in female pregnancy
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001894
name: tissue homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]
synonym: "tissue maintenance" NARROW [GOC:add]
is_a: GO:0060249 ! anatomical structure homeostasis
relationship: part_of GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0001895
name: retina homeostasis
namespace: biological_process
def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0001896
name: autolysis
namespace: biological_process
def: "A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation." [GOC:add, GOC:jh2, GOC:mtg_apoptosis, PMID:10974124, PMID:19286987, PMID:26811896]
xref: Wikipedia:Autolysis
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0001897
name: symbiont-mediated cytolysis of host cell
namespace: biological_process
def: "A process mediated by a symbiont that results in the death of a host cell by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11423190, PMID:23748204, PMID:24204713, PMID:27405240]
synonym: "cytolysis by organism of host cells" EXACT []
synonym: "cytolysis by symbiont of host cells" EXACT []
synonym: "pathogenesis" RELATED []
is_a: GO:0001907 ! symbiont-mediated killing of host cell
is_a: GO:0051715 ! cytolysis in another organism

[Term]
id: GO:0001898
name: obsolete regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0031640

[Term]
id: GO:0001899
name: obsolete negative regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "down regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "downregulation by symbiont of cytolysis of host cells" EXACT []
synonym: "inhibition by symbiont of cytolysis of host cells" NARROW []
synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0001900
name: obsolete positive regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "activation by symbiont of cytolysis of host cells" NARROW []
synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation by symbiont of cytolysis of host cells" NARROW []
synonym: "up regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "upregulation by symbiont of cytolysis of host cells" EXACT []
is_obsolete: true
consider: GO:0001907

[Term]
id: GO:0001905
name: activation of membrane attack complex
namespace: biological_process
def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149]
synonym: "activation of MAC" EXACT []
synonym: "activation of TCC" NARROW []
synonym: "activation of terminal complement complex" NARROW [GOC:add]
synonym: "activation of the terminal complement cascade" NARROW []
synonym: "MAC assembly" EXACT [GOC:rl]
synonym: "MAC formation" EXACT [GOC:rl]
synonym: "membrane attack complex assembly" EXACT [GOC:rl]
synonym: "membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0006956 ! complement activation

[Term]
id: GO:0001906
name: cell killing
namespace: biological_process
def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
synonym: "necrosis" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0001907
name: symbiont-mediated killing of host cell
namespace: biological_process
def: "A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, PMID:11123917, PMID:22992735, PMID:23230295, PMID:26633512]
subset: goslim_virus
synonym: "killing by symbiont of host cells" EXACT []
synonym: "pathogenesis" RELATED []
is_a: GO:0031640 ! killing of cells of another organism
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0001909
name: leukocyte mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:11911826]
comment: Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
synonym: "immune cell mediated cell death" EXACT []
synonym: "immune cell mediated cell killing" EXACT []
synonym: "immune cell mediated cytotoxicity" EXACT []
synonym: "leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001906 ! cell killing
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0001910
name: regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "regulation of immune cell mediated cell death" EXACT []
synonym: "regulation of immune cell mediated cell killing" EXACT []
synonym: "regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0031341 ! regulation of cell killing
relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001911
name: negative regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW []
synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0031342 ! negative regulation of cell killing
relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001912
name: positive regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "activation of leukocyte mediated cytotoxicity" NARROW []
synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW []
synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0031343 ! positive regulation of cell killing
relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001913
name: T cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
synonym: "T cell mediated apoptosis" EXACT []
synonym: "T cell mediated cell death" EXACT []
synonym: "T cell mediated cell killing" EXACT []
synonym: "T cell mediated cytolysis" RELATED []
synonym: "T lymphocyte mediated cytotoxicity" EXACT []
synonym: "T-cell mediated apoptosis" EXACT []
synonym: "T-cell mediated cell death" EXACT []
synonym: "T-cell mediated cell killing" EXACT []
synonym: "T-cell mediated cytotoxicity" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0001914
name: regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of T cell mediated apoptosis" EXACT []
synonym: "regulation of T cell mediated cell death" EXACT []
synonym: "regulation of T cell mediated cell killing" EXACT []
synonym: "regulation of T cell mediated cytolysis" RELATED []
synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "regulation of T-cell mediated apoptosis" EXACT []
synonym: "regulation of T-cell mediated cell death" EXACT []
synonym: "regulation of T-cell mediated cell killing" EXACT []
synonym: "regulation of T-cell mediated cytolysis" RELATED []
synonym: "regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002709 ! regulation of T cell mediated immunity
relationship: regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001915
name: negative regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of T cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of T cell mediated apoptosis" EXACT []
synonym: "negative regulation of T cell mediated cell death" EXACT []
synonym: "negative regulation of T cell mediated cell killing" EXACT []
synonym: "negative regulation of T cell mediated cytolysis" RELATED []
synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-cell mediated apoptosis" EXACT []
synonym: "negative regulation of T-cell mediated cell death" EXACT []
synonym: "negative regulation of T-cell mediated cell killing" EXACT []
synonym: "negative regulation of T-cell mediated cytolysis" RELATED []
synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001916
name: positive regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of T cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of T cell mediated apoptosis" EXACT []
synonym: "positive regulation of T cell mediated cell death" EXACT []
synonym: "positive regulation of T cell mediated cell killing" EXACT []
synonym: "positive regulation of T cell mediated cytolysis" RELATED []
synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-cell mediated apoptosis" EXACT []
synonym: "positive regulation of T-cell mediated cell death" EXACT []
synonym: "positive regulation of T-cell mediated cell killing" EXACT []
synonym: "positive regulation of T-cell mediated cytolysis" RELATED []
synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of T cell mediated cytotoxicity" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001917
name: photoreceptor inner segment
namespace: cellular_component
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]
subset: goslim_pir
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0001918
name: farnesylated protein binding
namespace: molecular_function
def: "Binding to a farnesylated protein." [GOC:add, PMID:14555765]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001919
name: regulation of receptor recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001920
name: negative regulation of receptor recycling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add]
synonym: "down regulation of receptor recycling" EXACT []
synonym: "down-regulation of receptor recycling" EXACT []
synonym: "downregulation of receptor recycling" EXACT []
synonym: "inhibition of receptor recycling" NARROW []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0023057 ! negative regulation of signaling
relationship: negatively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001921
name: positive regulation of receptor recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add]
synonym: "activation of receptor recycling" NARROW []
synonym: "stimulation of receptor recycling" NARROW []
synonym: "up regulation of receptor recycling" EXACT []
synonym: "up-regulation of receptor recycling" EXACT []
synonym: "upregulation of receptor recycling" EXACT []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0023056 ! positive regulation of signaling
relationship: positively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001922
name: B-1 B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B-1 B lymphocyte homeostasis" EXACT []
synonym: "B-1 B-cell homeostasis" EXACT []
synonym: "B-1 B-lymphocyte homeostasis" EXACT []
is_a: GO:0001782 ! B cell homeostasis

[Term]
id: GO:0001923
name: B-1 B cell differentiation
namespace: biological_process
def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
synonym: "B-1 B cell development" RELATED [GOC:add]
synonym: "B-1 B lymphocyte differentiation" EXACT []
synonym: "B-1 B-cell differentiation" EXACT []
synonym: "B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0002335 ! mature B cell differentiation

[Term]
id: GO:0001924
name: regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "regulation of B-1 B-cell differentiation" EXACT []
synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
relationship: regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001925
name: negative regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of B-1 B cell differentiation" EXACT []
synonym: "down-regulation of B-1 B cell differentiation" EXACT []
synonym: "downregulation of B-1 B cell differentiation" EXACT []
synonym: "inhibition of B-1 B cell differentiation" NARROW []
synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-1 B-cell differentiation" EXACT []
synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045578 ! negative regulation of B cell differentiation
relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001926
name: positive regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of B-1 B cell differentiation" NARROW []
synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-1 B-cell differentiation" EXACT []
synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B-1 B cell differentiation" NARROW []
synonym: "up regulation of B-1 B cell differentiation" EXACT []
synonym: "up-regulation of B-1 B cell differentiation" EXACT []
synonym: "upregulation of B-1 B cell differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045579 ! positive regulation of B cell differentiation
relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001927
name: exocyst assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst]
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis

[Term]
id: GO:0001928
name: regulation of exocyst assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd]
comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0106020 ! regulation of vesicle docking
relationship: regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001929
name: negative regulation of exocyst assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "down regulation of exocyst assembly" EXACT []
synonym: "down-regulation of exocyst assembly" EXACT []
synonym: "downregulation of exocyst assembly" EXACT []
synonym: "inhibition of exocyst assembly" NARROW []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0045920 ! negative regulation of exocytosis
relationship: negatively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001930
name: positive regulation of exocyst assembly
namespace: biological_process
def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "activation of exocyst assembly" NARROW []
synonym: "stimulation of exocyst assembly" NARROW []
synonym: "up regulation of exocyst assembly" EXACT []
synonym: "up-regulation of exocyst assembly" EXACT []
synonym: "upregulation of exocyst assembly" EXACT []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
relationship: positively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001931
name: uropod
namespace: cellular_component
def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]
synonym: "distal pole complex" RELATED []
synonym: "retractile pole" RELATED []
synonym: "uropodium" EXACT []
is_a: GO:0120025 ! plasma membrane bounded cell projection
relationship: part_of GO:0031254 ! cell trailing edge

[Term]
id: GO:0001932
name: regulation of protein phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0042325 ! regulation of phosphorylation
relationship: regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001933
name: negative regulation of protein phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein amino acid phosphorylation" EXACT []
synonym: "down-regulation of protein amino acid phosphorylation" EXACT []
synonym: "downregulation of protein amino acid phosphorylation" EXACT []
synonym: "inhibition of protein amino acid phosphorylation" NARROW []
synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0042326 ! negative regulation of phosphorylation
relationship: negatively_regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001934
name: positive regulation of protein phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein amino acid phosphorylation" NARROW []
synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid phosphorylation" NARROW []
synonym: "up regulation of protein amino acid phosphorylation" EXACT []
synonym: "up-regulation of protein amino acid phosphorylation" EXACT []
synonym: "upregulation of protein amino acid phosphorylation" EXACT []
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0042327 ! positive regulation of phosphorylation
relationship: positively_regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001935
name: endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0001936
name: regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001937
name: negative regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "down regulation of endothelial cell proliferation" EXACT []
synonym: "down-regulation of endothelial cell proliferation" EXACT []
synonym: "downregulation of endothelial cell proliferation" EXACT []
synonym: "inhibition of endothelial cell proliferation" NARROW []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001938
name: positive regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "activation of endothelial cell proliferation" NARROW []
synonym: "stimulation of endothelial cell proliferation" NARROW []
synonym: "up regulation of endothelial cell proliferation" EXACT []
synonym: "up-regulation of endothelial cell proliferation" EXACT []
synonym: "upregulation of endothelial cell proliferation" EXACT []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
relationship: positively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001939
name: female pronucleus
namespace: cellular_component
def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001940
name: male pronucleus
namespace: cellular_component
def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001941
name: postsynaptic membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]
synonym: "post-synaptic membrane organization" EXACT []
synonym: "postsynaptic membrane organisation" EXACT []
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0099173 ! postsynapse organization

[Term]
id: GO:0001942
name: hair follicle development
namespace: biological_process
alt_id: GO:0001943
def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073]
is_a: GO:0022405 ! hair cycle process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0098773 ! skin epidermis development

[Term]
id: GO:0001944
name: vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]
synonym: "vascular system development" RELATED []
is_a: GO:0048731 ! system development
relationship: part_of GO:0072359 ! circulatory system development

[Term]
id: GO:0001945
name: lymph vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001946
name: lymphangiogenesis
namespace: biological_process
def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157]
synonym: "lymph vessel formation" EXACT systematic_synonym []
xref: Wikipedia:Lymphangiogenesis
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0036303 ! lymph vessel morphogenesis

[Term]
id: GO:0001947
name: heart looping
namespace: biological_process
def: "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation." [GOC:dph, PMID:12094232]
synonym: "cardiac looping" EXACT []
is_a: GO:0003143 ! embryonic heart tube morphogenesis
relationship: part_of GO:0061371 ! determination of heart left/right asymmetry

[Term]
id: GO:0001949
name: sebaceous gland cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203]
synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators]
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0048733 ! sebaceous gland development

[Term]
id: GO:0001950
name: obsolete plasma membrane enriched fraction
namespace: cellular_component
def: "OBSOLETE. The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "plasma membrane enriched fraction" EXACT []
synonym: "PME fraction" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0005886

[Term]
id: GO:0001951
name: intestinal D-glucose absorption
namespace: biological_process
def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832]
is_a: GO:0106001 ! intestinal hexose absorption

[Term]
id: GO:0001952
name: regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
relationship: regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001953
name: negative regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd]
synonym: "down regulation of cell-matrix adhesion" EXACT []
synonym: "down-regulation of cell-matrix adhesion" EXACT []
synonym: "downregulation of cell-matrix adhesion" EXACT []
synonym: "inhibition of cell-matrix adhesion" NARROW []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001954
name: positive regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd]
synonym: "activation of cell-matrix adhesion" NARROW []
synonym: "stimulation of cell-matrix adhesion" NARROW []
synonym: "up regulation of cell-matrix adhesion" EXACT []
synonym: "up-regulation of cell-matrix adhesion" EXACT []
synonym: "upregulation of cell-matrix adhesion" EXACT []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
relationship: positively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001955
name: blood vessel maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0001956
name: positive regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
synonym: "activation of neurotransmitter secretion" NARROW []
synonym: "stimulation of neurotransmitter secretion" NARROW []
synonym: "up regulation of neurotransmitter secretion" EXACT []
synonym: "up-regulation of neurotransmitter secretion" EXACT []
synonym: "upregulation of neurotransmitter secretion" EXACT []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0001957
name: intramembranous ossification
namespace: biological_process
def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437]
comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "dermal ossification" NARROW [GO_REF:0000034]
synonym: "intramembranous bone ossification" RELATED [GOC:cjm]
xref: Wikipedia:Intramembranous_ossification
is_a: GO:0036072 ! direct ossification

[Term]
id: GO:0001958
name: endochondral ossification
namespace: biological_process
def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437]
xref: Wikipedia:Endochondral_ossification
is_a: GO:0036075 ! replacement ossification
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0001959
name: regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001960
name: negative regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "down regulation of cytokine mediated signaling pathway" EXACT []
synonym: "down-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "downregulation of cytokine mediated signaling pathway" EXACT []
synonym: "inhibition of cytokine mediated signaling pathway" NARROW []
synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001961
name: positive regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]
synonym: "activation of cytokine mediated signaling pathway" NARROW []
synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of cytokine mediated signalling pathway" EXACT []
synonym: "stimulation of cytokine mediated signaling pathway" NARROW []
synonym: "up regulation of cytokine mediated signaling pathway" EXACT []
synonym: "up-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "upregulation of cytokine mediated signaling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001962
name: alpha-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427]
synonym: "isoglobotriaosylceramide synthase" NARROW []
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0001963
name: synaptic transmission, dopaminergic
namespace: biological_process
def: "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph]
synonym: "dopaminergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0001964
name: startle response
namespace: biological_process
def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
xref: Wikipedia:Startle_reaction
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0001965
name: G-protein alpha-subunit binding
namespace: molecular_function
def: "Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]
synonym: "G-alpha protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001966
name: thigmotaxis
namespace: biological_process
def: "The directed movement of an animal in response to touch." [GOC:dph]
synonym: "stereotaxis" EXACT []
synonym: "taxis in response to mechanical stimulus" BROAD []
synonym: "taxis in response to touch stimulus" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0001967
name: suckling behavior
namespace: biological_process
def: "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast." [GOC:dph, GOC:pr]
synonym: "nursing behavior" EXACT []
is_a: GO:0007631 ! feeding behavior

[Term]
id: GO:0001968
name: fibronectin binding
namespace: molecular_function
def: "Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001969
name: regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "regulation of activation of MAC" EXACT [GOC:mah]
synonym: "regulation of activation of TCC" NARROW [GOC:mah]
synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "regulation of MAC assembly" EXACT [GOC:rl]
synonym: "regulation of MAC formation" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0030449 ! regulation of complement activation
relationship: regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001970
name: positive regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "activation of activation of membrane attack complex" NARROW []
synonym: "positive regulation of activation of MAC" EXACT [GOC:mah]
synonym: "positive regulation of activation of TCC" NARROW [GOC:mah]
synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "positive regulation of MAC assembly" EXACT [GOC:rl]
synonym: "positive regulation of MAC formation" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl]
synonym: "stimulation of activation of membrane attack complex" NARROW []
synonym: "up regulation of activation of membrane attack complex" EXACT []
synonym: "up-regulation of activation of membrane attack complex" EXACT []
synonym: "upregulation of activation of membrane attack complex" EXACT []
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001971
name: negative regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "down regulation of activation of membrane attack complex" EXACT []
synonym: "down-regulation of activation of membrane attack complex" EXACT []
synonym: "downregulation of activation of membrane attack complex" EXACT []
synonym: "inhibition of activation of membrane attack complex" NARROW []
synonym: "negative regulation of activation of MAC" EXACT [GOC:mah]
synonym: "negative regulation of activation of TCC" NARROW [GOC:mah]
synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "negative regulation of MAC assembly" EXACT [GOC:rl]
synonym: "negative regulation of MAC formation" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001972
name: retinoic acid binding
namespace: molecular_function
def: "Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd]
is_a: GO:0005501 ! retinoid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0001973
name: G protein-coupled adenosine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph]
synonym: "adenosine receptor signaling pathway" RELATED []
synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289]
synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah]
synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289]
is_a: GO:0035588 ! G protein-coupled purinergic receptor signaling pathway

[Term]
id: GO:0001974
name: blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing blood vessels." [GOC:hjd]
synonym: "blood vessel remodelling" EXACT []
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0001975
name: response to amphetamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:dph, GOC:ef]
is_a: GO:0014075 ! response to amine

[Term]
id: GO:0001976
name: nervous system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by neurological process" EXACT []
synonym: "fast control of arterial pressure" RELATED []
synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "neurological system process involved in regulation of systemic arterial blood pressure" EXACT []
is_a: GO:0050877 ! nervous system process
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0001977
name: renal system process involved in regulation of blood volume
namespace: biological_process
def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]
subset: gocheck_obsoletion_candidate
synonym: "renal blood volume control of blood pressure" RELATED []
synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0001978
name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "baroreceptor feedback control of blood pressure" RELATED []
synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X]
synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0001979
name: regulation of systemic arterial blood pressure by chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "chemoreceptor control of blood pressure" RELATED []
synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001980
name: regulation of systemic arterial blood pressure by ischemic conditions
namespace: biological_process
def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "CNS ischemic response" RELATED [ISBN:0721643949]
synonym: "ischemic control of blood pressure" RELATED []
synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001981
name: baroreceptor detection of arterial stretch
namespace: biological_process
def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0001982
name: baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0001983
name: baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0001984
name: artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949]
synonym: "vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure" EXACT []
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001985
name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949]
synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW []
synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED []
synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001986
name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT []
synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0045822 ! negative regulation of heart contraction
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001987
name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001988
name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED []
synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001989
name: obsolete positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "OBSOLETE. Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED []
synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED []
synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0001990
name: regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by hormone" EXACT []
synonym: "hormonal control of blood pressure" RELATED []
synonym: "hormonal regulation of blood pressure" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
is_a: GO:0050886 ! endocrine process

[Term]
id: GO:0001991
name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin
namespace: biological_process
def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949]
synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT []
synonym: "circulatory renin-angiotensin control of blood pressure" RELATED []
synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT []
synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED []
synonym: "renin-angiotensin blood pressure control" RELATED []
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0001992
name: regulation of systemic arterial blood pressure by vasopressin
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by vasopressin" EXACT []
synonym: "vasopressin control of blood pressure" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0001993
name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949]
synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED []
synonym: "norepinephrine-epinephrine blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0001994
name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED []
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001995
name: norepinephrine-epinephrine catabolic process in blood stream
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd]
synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT []
is_a: GO:0042419 ! epinephrine catabolic process
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0001996
name: positive regulation of heart rate by epinephrine-norepinephrine
namespace: biological_process
def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph]
synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED []
synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001997
name: positive regulation of the force of heart contraction by epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio]
synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT []
synonym: "increased inotropy by epinephrine-norepinephrine" RELATED []
synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001998
name: angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, GOC:pr, ISBN:0721643949]
synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED []
synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT []
synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED []
synonym: "angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure" EXACT []
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0002034 ! maintenance of blood vessel diameter homeostasis by renin-angiotensin

[Term]
id: GO:0001999
name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
namespace: biological_process
def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph]
synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002000
name: detection of renal blood flow
namespace: biological_process
def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949]
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002001
name: renin secretion into blood stream
namespace: biological_process
def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949]
synonym: "renin release into blood stream" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0023061 ! signal release
relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002002
name: regulation of angiotensin levels in blood
namespace: biological_process
def: "The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation." [GOC:rl, PMID:21951628, Wikipedia:Angiotensin]
synonym: "control of angiotensin levels in blood" RELATED []
synonym: "control of blood angiotensin level" RELATED []
synonym: "regulation of blood angiotensin level" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002003
name: angiotensin maturation
namespace: biological_process
alt_id: GO:0002005
def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood." [ISBN:0721643949]
synonym: "angiotensin catabolic process in blood" NARROW []
is_a: GO:0016486 ! peptide hormone processing
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0002004
name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949]
synonym: "secretion of vasopressin during fast control of blood pressure" RELATED []
synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0030103 ! vasopressin secretion
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002006
name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002007
name: detection of hypoxic conditions in blood by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph]
synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: part_of GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0002008
name: excitation of vasomotor center by chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT []
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002009
name: morphogenesis of an epithelium
namespace: biological_process
def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
synonym: "epithelium morphogenesis" EXACT []
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0060429 ! epithelium development

[Term]
id: GO:0002010
name: excitation of vasomotor center by baroreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT []
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0002011
name: morphogenesis of an epithelial sheet
namespace: biological_process
def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0002012
name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0002013
name: detection of carbon dioxide by vasomotor center
namespace: biological_process
def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002014
name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002015
name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback
namespace: biological_process
def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb]
synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "atrial control of blood pressure" RELATED []
synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio]
synonym: "atrial reflex" RELATED [GOC:dph]
is_a: GO:0003015 ! heart process
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0002016
name: regulation of blood volume by renin-angiotensin
namespace: biological_process
def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "renin-angiotensin control of body fluid levels" RELATED []
synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0002017
name: regulation of blood volume by renal aldosterone
namespace: biological_process
def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "aldosterone mediated control of body fluids" RELATED []
synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002018
name: renin-angiotensin regulation of aldosterone production
namespace: biological_process
def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949]
synonym: "renin-angiotensin control of aldosterone production" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
is_a: GO:2000858 ! regulation of aldosterone secretion
relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002019
name: regulation of renal output by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "angiotensin mediated control of renal output" RELATED []
synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002020
name: protease binding
namespace: molecular_function
def: "Binding to a protease or a peptidase." [GOC:hjd]
xref: Reactome:R-HSA-1297354 "Acrosin Cleavage"
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0002021
name: response to dietary excess
namespace: biological_process
def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [GOC:pg, GOC:pr, PMID:12161655]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0097009 ! energy homeostasis

[Term]
id: GO:0002022
name: detection of dietary excess
namespace: biological_process
def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655]
is_a: GO:0050877 ! nervous system process
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002023
name: reduction of food intake in response to dietary excess
namespace: biological_process
def: "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients." [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200]
is_a: GO:0042755 ! eating behavior
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002024
name: diet induced thermogenesis
namespace: biological_process
def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system." [PMID:12161655]
is_a: GO:1990845 ! adaptive thermogenesis
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002025
name: norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008]
synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT []
synonym: "vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure" EXACT []
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0002026
name: regulation of the force of heart contraction
namespace: biological_process
def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb]
synonym: "heart inotropy" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002027
name: regulation of heart rate
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of heart contraction rate" EXACT []
synonym: "regulation of rate of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002028
name: regulation of sodium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
synonym: "regulation of Na+ transport" EXACT []
synonym: "regulation of sodium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0002029
name: desensitization of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway." [PMID:8396717]
synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "desensitization of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0022401 ! negative adaptation of signaling pathway
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway

[Term]
id: GO:0002030
name: inhibitory G protein-coupled receptor phosphorylation
namespace: biological_process
def: "The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717]
subset: gocheck_obsoletion_candidate
synonym: "inhibitory G-protein coupled receptor phosphorylation" EXACT []
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway

[Term]
id: GO:0002031
name: G protein-coupled receptor internalization
namespace: biological_process
def: "The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle." [PMID:8396717]
synonym: "G-protein coupled receptor internalization" EXACT []
is_a: GO:0031623 ! receptor internalization
relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway

[Term]
id: GO:0002032
name: obsolete desensitization of G protein-coupled receptor signaling pathway by arrestin
namespace: biological_process
def: "OBSOLETE. The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717]
comment: The reason for obsoletion is that this term represents a gene product arrestin.
synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "desensitization of G-protein coupled receptor protein signaling pathway by arrestin" EXACT []
is_obsolete: true
replaced_by: GO:0002029

[Term]
id: GO:0002033
name: angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the diameter of a blood vessel via the renin-angiotensin system." [GOC:pr, ISBN:0323031951, PMID:10425188]
synonym: "vasodilation by angiotensin involved in regulation of systemic arterial blood pressure" EXACT []
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0002034 ! maintenance of blood vessel diameter homeostasis by renin-angiotensin

[Term]
id: GO:0002034
name: maintenance of blood vessel diameter homeostasis by renin-angiotensin
namespace: biological_process
def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:pr, GOC:tb]
synonym: "regulation of blood vessel diameter by renin-angiotensin" EXACT []
synonym: "regulation of blood vessel size by renin-angiotensin" BROAD []
synonym: "renin-angiotensin regulation of blood vessel size" BROAD [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin
is_a: GO:0097746 ! blood vessel diameter maintenance

[Term]
id: GO:0002035
name: brain renin-angiotensin system
namespace: biological_process
def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002036
name: regulation of L-glutamate import across plasma membrane
namespace: biological_process
alt_id: GO:1900920
def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "regulation of L-glutamate import" BROAD []
synonym: "regulation of L-glutamate transport" BROAD []
synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:0098712 ! L-glutamate import across plasma membrane

[Term]
id: GO:0002037
name: negative regulation of L-glutamate import across plasma membrane
namespace: biological_process
alt_id: GO:1900921
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamate transport" BROAD []
synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamate transport" BROAD []
synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamate transport" BROAD []
synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamate transport" NARROW []
synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-glutamate import" BROAD []
synonym: "negative regulation of L-glutamate transport" BROAD []
synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "regulation of L-glutamate import" BROAD []
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
relationship: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane

[Term]
id: GO:0002038
name: positive regulation of L-glutamate import across plasma membrane
namespace: biological_process
alt_id: GO:1900922
def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamate transport" NARROW []
synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-glutamate import" BROAD []
synonym: "positive regulation of L-glutamate transport" BROAD []
synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "stimulation of L-glutamate transport" NARROW []
synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamate transport" BROAD []
synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamate transport" EXACT []
synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamate transport" BROAD []
synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
relationship: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane

[Term]
id: GO:0002039
name: p53 binding
namespace: molecular_function
def: "Binding to one of the p53 family of proteins." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002040
name: sprouting angiogenesis
namespace: biological_process
def: "The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation." [PMID:16391003, PMID:23031691]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002041
name: intussusceptive angiogenesis
namespace: biological_process
def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002042
name: cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002043
name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003]
synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001935 ! endothelial cell proliferation
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002044
name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002045
name: regulation of cell adhesion involved in intussusceptive angiogenesis
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002046
name: opsin binding
namespace: molecular_function
alt_id: GO:0016030
def: "Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd]
synonym: "metarhodopsin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002047
name: phenazine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph]
synonym: "acridizine biosynthesis" RELATED []
synonym: "acridizine biosynthetic process" RELATED []
synonym: "azophenylene biosynthesis" RELATED []
synonym: "azophenylene biosynthetic process" RELATED []
synonym: "dibenzo-p-diazine biosynthesis" RELATED []
synonym: "dibenzo-p-diazine biosynthetic process" RELATED []
synonym: "dibenzopyrazine biosynthesis" RELATED []
synonym: "dibenzopyrazine biosynthetic process" RELATED []
is_a: GO:0017000 ! antibiotic biosynthetic process

[Term]
id: GO:0002048
name: pyoverdine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763]
synonym: "pyoverdine metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0002049
name: pyoverdine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0002050
name: pyoverdine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0002051
name: osteoblast fate commitment
namespace: biological_process
def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002052
name: positive regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
synonym: "activation of neuroblast proliferation" NARROW []
synonym: "stimulation of neuroblast proliferation" NARROW []
synonym: "up regulation of neuroblast proliferation" EXACT []
synonym: "up-regulation of neuroblast proliferation" EXACT []
synonym: "upregulation of neuroblast proliferation" EXACT []
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
relationship: positively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
namespace: biological_process
def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]
synonym: "activation of mesenchymal cell proliferation" NARROW []
synonym: "stimulation of mesenchymal cell proliferation" NARROW []
synonym: "up regulation of mesenchymal cell proliferation" EXACT []
synonym: "up-regulation of mesenchymal cell proliferation" EXACT []
synonym: "upregulation of mesenchymal cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0002054
name: nucleobase binding
namespace: molecular_function
def: "Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd]
subset: goslim_pir
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0002055
name: adenine binding
namespace: molecular_function
def: "Binding to adenine, a purine base." [GOC:hjd]
synonym: "6-aminopurine binding" EXACT []
is_a: GO:0002060 ! purine nucleobase binding

[Term]
id: GO:0002056
name: cytosine binding
namespace: molecular_function
def: "Binding to cytosine." [GOC:hjd, GOC:vw]
is_a: GO:0002061 ! pyrimidine nucleobase binding

[Term]
id: GO:0002057
name: guanine binding
namespace: molecular_function
def: "Binding to guanine." [GOC:hjd]
is_a: GO:0002060 ! purine nucleobase binding

[Term]
id: GO:0002058
name: uracil binding
namespace: molecular_function
def: "Binding to uracil." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine nucleobase binding

[Term]
id: GO:0002059
name: thymine binding
namespace: molecular_function
def: "Binding to thymine." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine nucleobase binding

[Term]
id: GO:0002060
name: purine nucleobase binding
namespace: molecular_function
def: "Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton." [GOC:hjd]
synonym: "purine base binding" EXACT [GOC:go_curators]
synonym: "purine binding" RELATED []
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002061
name: pyrimidine nucleobase binding
namespace: molecular_function
def: "Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton." [GOC:hjd]
synonym: "1,3-diazine binding" NARROW []
synonym: "pyrimidine base binding" EXACT [GOC:go_curators]
synonym: "pyrimidine binding" RELATED []
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002062
name: chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0002063
name: chondrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0002064
name: epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002066
name: columnar/cuboidal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002067
name: glandular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002068
name: glandular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: part_of GO:0002067 ! glandular epithelial cell differentiation

[Term]
id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development

[Term]
id: GO:0002070
name: epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0002064 ! epithelial cell development

[Term]
id: GO:0002071
name: glandular epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
relationship: part_of GO:0002068 ! glandular epithelial cell development

[Term]
id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
namespace: biological_process
def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT []
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0002074
name: extraocular skeletal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development
is_a: GO:0060538 ! skeletal muscle organ development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002075
name: somitomeric trunk muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982]
is_a: GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0002076
name: osteoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002077
name: acrosome matrix dispersal
namespace: biological_process
def: "The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane." [GOC:dph, PMID:3886029]
is_a: GO:0051603 ! proteolysis involved in protein catabolic process
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002078
name: membrane fusion involved in acrosome reaction
namespace: biological_process
def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029]
synonym: "membrane fusion involved in the acrosomal reaction" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0061025 ! membrane fusion
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002079
name: inner acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002080
name: acrosomal membrane
namespace: cellular_component
def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0002081
name: outer acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002082
name: regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]
synonym: "OXPHOS" EXACT []
is_a: GO:1903715 ! regulation of aerobic respiration
relationship: regulates GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0002083
name: obsolete 4-hydroxybenzoate decaprenyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of 4-hydroxybenzoate polyprenyltransferase activity ; GO:0008412.
xref: Reactome:R-HSA-2162192 "COQ2 ligates all-E-10PrP2 to PHB"
is_obsolete: true
replaced_by: GO:0008412

[Term]
id: GO:0002084
name: protein depalmitoylation
namespace: biological_process
def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
is_a: GO:0035601 ! protein deacylation
is_a: GO:0042159 ! lipoprotein catabolic process
is_a: GO:0098734 ! macromolecule depalmitoylation

[Term]
id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]
synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb]
synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048505 ! regulation of timing of cell differentiation
relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0002086
name: diaphragm contraction
namespace: biological_process
def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206]
is_a: GO:0003011 ! involuntary skeletal muscle contraction
is_a: GO:0003016 ! respiratory system process

[Term]
id: GO:0002087
name: regulation of respiratory gaseous exchange by nervous system process
namespace: biological_process
def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]
synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT []
is_a: GO:0044065 ! regulation of respiratory system process
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0002088
name: lens development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]
synonym: "lens development" EXACT []
synonym: "lens development in camera-style eye" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002089
name: lens morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]
synonym: "lens morphogenesis" EXACT []
synonym: "lens morphogenesis in camera-style eye" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0002088 ! lens development in camera-type eye
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0002090
name: regulation of receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
relationship: regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002091
name: negative regulation of receptor internalization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "down regulation of receptor internalization" EXACT []
synonym: "down-regulation of receptor internalization" EXACT []
synonym: "downregulation of receptor internalization" EXACT []
synonym: "inhibition of receptor internalization" NARROW []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
relationship: negatively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002092
name: positive regulation of receptor internalization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "activation of receptor internalization" NARROW []
synonym: "stimulation of receptor internalization" NARROW []
synonym: "up regulation of receptor internalization" EXACT []
synonym: "up-regulation of receptor internalization" EXACT []
synonym: "upregulation of receptor internalization" EXACT []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
relationship: positively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002093
name: auditory receptor cell morphogenesis
namespace: biological_process
def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb]
synonym: "hair cell morphogenesis" BROAD [GO:dph]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060117 ! auditory receptor cell development

[Term]
id: GO:0002094
name: polyprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0002095
name: caveolar macromolecular signaling complex
namespace: cellular_component
def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270]
synonym: "caveolar macromolecular signalling complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0002096
name: polkadots
namespace: cellular_component
def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340]
comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots.
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0002097
name: tRNA wobble base modification
namespace: biological_process
def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0002098
name: tRNA wobble uridine modification
namespace: biological_process
def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002099
name: tRNA wobble guanine modification
namespace: biological_process
def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002100
name: tRNA wobble adenosine to inosine editing
namespace: biological_process
def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification
is_a: GO:0006382 ! adenosine to inosine editing

[Term]
id: GO:0002101
name: tRNA wobble cytosine modification
namespace: biological_process
def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002102
name: podosome
namespace: cellular_component
def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]
comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
xref: Wikipedia:Podosome
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0002103
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0002104
name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002105
name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002106
name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002107
name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
namespace: biological_process
def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357]
is_a: GO:0000481 ! maturation of 5S rRNA
is_a: GO:0031125 ! rRNA 3'-end processing

[Term]
id: GO:0002108
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0002109
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0002110
name: cotranscriptional mitochondrial rRNA nucleotide insertion
namespace: biological_process
def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0002111
name: BRCA2-BRAF35 complex
namespace: cellular_component
def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0002112
name: interleukin-33 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-33 receptor." [GOC:hjd]
synonym: "IL-33" NARROW [GOC:mah]
synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah]
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0002113
name: interleukin-33 binding
namespace: molecular_function
def: "Binding to interleukin-33." [GOC:hjd]
synonym: "IL-33 binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0002114
name: interleukin-33 receptor activity
namespace: molecular_function
def: "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "IL-33 receptor activity" EXACT [GOC:mah]
synonym: "IL-33R" EXACT [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0002115
name: store-operated calcium entry
namespace: biological_process
def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum.
synonym: "calcium ion import" BROAD []
synonym: "capacitative calcium entry" EXACT []
synonym: "SOCE" EXACT []
synonym: "store-operated calcium import" EXACT []
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0002116
name: semaphorin receptor complex
namespace: cellular_component
def: "A stable binary complex of a semaphorin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544]
synonym: "plexin-neurophilin complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0002117
name: amphibian larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, PMID:27143402]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002118
name: aggressive behavior
namespace: biological_process
def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
synonym: "aggression" EXACT []
xref: Wikipedia:Aggression
is_a: GO:0007610 ! behavior

[Term]
id: GO:0002119
name: nematode larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002120
name: obsolete predatory behavior
namespace: biological_process
def: "OBSOLETE. Aggressive behavior involving attack on prey by a predator." [GOC:hjd]
comment: This term was obsoleted because it is outside the scope of GO.
synonym: "predatory aggression" EXACT []
synonym: "predatory aggressive behavior" EXACT []
is_obsolete: true

[Term]
id: GO:0002121
name: inter-male aggressive behavior
namespace: biological_process
def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
synonym: "inter-male aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002122
name: fear-induced aggressive behavior
namespace: biological_process
def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd]
synonym: "fear-induced aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002123
name: irritable aggressive behavior
namespace: biological_process
def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd]
synonym: "irritable aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002124
name: territorial aggressive behavior
namespace: biological_process
def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd]
synonym: "territorial aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002125
name: maternal aggressive behavior
namespace: biological_process
def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd]
comment: Paternal aggression also exists. Serves to protect the offspring from intruders.
synonym: "maternal aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002126
name: instrumental aggressive behavior
namespace: biological_process
def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd]
synonym: "instrumental aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002127
name: tRNA wobble base cytosine methylation
namespace: biological_process
def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X]
synonym: "wobble position m5C biosynthesis" EXACT []
is_a: GO:0002101 ! tRNA wobble cytosine modification
is_a: GO:0002946 ! tRNA C5-cytosine methylation

[Term]
id: GO:0002128
name: tRNA nucleoside ribose methylation
namespace: biological_process
def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002129
name: wobble position guanine ribose methylation
namespace: biological_process
def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation
is_a: GO:0002938 ! tRNA guanine ribose methylation

[Term]
id: GO:0002130
name: wobble position ribose methylation
namespace: biological_process
def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002128 ! tRNA nucleoside ribose methylation

[Term]
id: GO:0002131
name: wobble position cytosine ribose methylation
namespace: biological_process
def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002132
name: wobble position uridine ribose methylation
namespace: biological_process
def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002133
name: polycystin complex
namespace: cellular_component
def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144]
comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant).
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0002134
name: UTP binding
namespace: molecular_function
def: "Binding to UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732]
is_a: GO:0032557 ! pyrimidine ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0002135
name: CTP binding
namespace: molecular_function
def: "Binding to CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607]
is_a: GO:0032557 ! pyrimidine ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0002136
name: tRNA wobble base lysidine biosynthesis
namespace: biological_process
def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617]
comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP.
is_a: GO:0002101 ! tRNA wobble cytosine modification

[Term]
id: GO:0002138
name: retinoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd]
synonym: "retinoic acid anabolic process" EXACT []
synonym: "retinoic acid biosynthesis" EXACT []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0042573 ! retinoic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0002139
name: stereocilia coupling link
namespace: cellular_component
def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032421 ! stereocilium bundle

[Term]
id: GO:0002140
name: stereocilia tip link
namespace: cellular_component
def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787]
is_a: GO:0002139 ! stereocilia coupling link

[Term]
id: GO:0002141
name: stereocilia ankle link
namespace: cellular_component
def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809]
is_a: GO:0002139 ! stereocilia coupling link

[Term]
id: GO:0002142
name: stereocilia ankle link complex
namespace: cellular_component
def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0002141 ! stereocilia ankle link

[Term]
id: GO:0002143
name: tRNA wobble position uridine thiolation
namespace: biological_process
def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210]
comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah]
synonym: "wobble position s2U biosynthesis" EXACT []
is_a: GO:0002098 ! tRNA wobble uridine modification
is_a: GO:0034227 ! tRNA thio-modification

[Term]
id: GO:0002144
name: cytosolic tRNA wobble base thiouridylase complex
namespace: cellular_component
def: "A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets." [PMID:17062623, PMID:18391219]
synonym: "Ctu1-Ctu2 complex" NARROW []
synonym: "tRNA thiouridylase" BROAD []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990228 ! sulfurtransferase complex

[Term]
id: GO:0002145
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+." [MetaCyc:RXN0-3543]
synonym: "HMP-PP diphosphatase" EXACT []
synonym: "HMP-PP pyrophosphatase" EXACT []
xref: MetaCyc:RXN0-3543
xref: RHEA:27914
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0002146
name: obsolete steroid hormone receptor import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0006606
consider: GO:0042306

[Term]
id: GO:0002147
name: obsolete glucocorticoid receptor import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0042306

[Term]
id: GO:0002148
name: hypochlorous acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150]
synonym: "HClO metabolic process" EXACT []
synonym: "HOCl metabolic process" EXACT []
synonym: "hypochlorite metabolic process" RELATED []
synonym: "hypochlorous acid metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:0002149
name: hypochlorous acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150]
comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils.
synonym: "HClO biosynthetic process" EXACT []
synonym: "HOCl biosynthetic process" EXACT []
synonym: "hypochlorite biosynthetic process" RELATED []
synonym: "hypochlorous acid biosynthesis" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1903409 ! reactive oxygen species biosynthetic process

[Term]
id: GO:0002150
name: hypochlorous acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add]
synonym: "HClO catabolic process" EXACT []
synonym: "HOCl catabolic process" EXACT []
synonym: "hypochlorite catabolic process" RELATED []
synonym: "hypochlorous acid catabolism" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0002151
name: G-quadruplex RNA binding
namespace: molecular_function
def: "Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]
comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure.
synonym: "G quadruplex binding" EXACT [GOC:mah]
synonym: "G quartet binding" BROAD [GOC:hjd]
synonym: "G quartet RNA binding" EXACT [GOC:hjd]
synonym: "G-quartet binding" BROAD [GOC:mah]
xref: Reactome:R-HSA-9836998 "GRSF1 unwinds quadruplex G regions in RNA"
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0002152
name: bile acid conjugation
namespace: biological_process
def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413]
comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine).
is_a: GO:0008206 ! bile acid metabolic process

[Term]
id: GO:0002153
name: steroid receptor RNA activator RNA binding
namespace: molecular_function
def: "Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [GOC:vw, PMID:10199399, PMID:15180993]
comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken).
synonym: "SRA binding" EXACT []
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0002154
name: thyroid hormone receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a thyroid hormone  binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:hjd]
synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0141193 ! nuclear receptor-mediated signaling pathway

[Term]
id: GO:0002155
name: regulation of thyroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "regulation of thyroid hormone mediated signaling pathway" EXACT []
synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0002154 ! thyroid hormone receptor signaling pathway

[Term]
id: GO:0002156
name: negative regulation of thyroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "negative regulation of thyroid hormone mediated signaling pathway" EXACT []
synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0002155 ! regulation of thyroid hormone receptor signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0002154 ! thyroid hormone receptor signaling pathway

[Term]
id: GO:0002157
name: positive regulation of thyroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "positive regulation of thyroid hormone mediated signaling pathway" EXACT []
synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0002155 ! regulation of thyroid hormone receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0002154 ! thyroid hormone receptor signaling pathway

[Term]
id: GO:0002158
name: osteoclast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd]
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0002159
name: desmosome assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0002934 ! desmosome organization
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0002160
name: desmosome maintenance
namespace: biological_process
def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0002934 ! desmosome organization
is_a: GO:0045217 ! cell-cell junction maintenance

[Term]
id: GO:0002161
name: aminoacyl-tRNA editing activity
namespace: molecular_function
def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]
synonym: "amino acid proofreading activity" RELATED []
synonym: "aminoacyl-tRNA hydrolysis activity" RELATED []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0002162
name: dystroglycan binding
namespace: molecular_function
alt_id: GO:0002163
alt_id: GO:0002166
def: "Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd]
synonym: "alpha-dystroglycan binding" NARROW []
synonym: "beta-dystroglycan binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002164
name: larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002165
name: instar larval or pupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002167
name: VRK3/VHR/ERK complex
namespace: cellular_component
def: "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0002168
name: instar larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002164 ! larval development
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0002169
name: obsolete 3-methylcrotonyl-CoA carboxylase complex, mitochondrial
namespace: cellular_component
def: "OBSOLETE. A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, PMID:15868465, PMID:17360195, PMID:22869039]
comment: The reason for obsoletion is that this term is equivalent to GO:1905202 methylcrotonoyl-CoA carboxylase complex.
synonym: "mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme" EXACT [PMID:22869039]
synonym: "mitochondrial MCCC complex" EXACT [GOC:bf]
synonym: "mitochondrial methylcrotonoyl-CoA carboxylase complex" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:1905202

[Term]
id: GO:0002170
name: high-affinity IgA receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "high affinity IgA receptor activity" EXACT []
is_a: GO:0019766 ! IgA receptor activity

[Term]
id: GO:0002171
name: low-affinity IgA receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "low affinity IgA receptor activity" EXACT []
is_a: GO:0019766 ! IgA receptor activity

[Term]
id: GO:0002172
name: high-affinity IgM receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "high affinity IgM receptor activity" EXACT []
is_a: GO:0001793 ! IgM receptor activity

[Term]
id: GO:0002173
name: low-affinity IgM receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "low affinity IgM receptor activity" EXACT []
is_a: GO:0001793 ! IgM receptor activity

[Term]
id: GO:0002174
name: mammary stem cell proliferation
namespace: biological_process
def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0002175
name: protein localization to paranode region of axon
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321]
synonym: "protein localisation to paranode region of axon" EXACT [GOC:mah]
is_a: GO:0099612 ! protein localization to axon

[Term]
id: GO:0002176
name: male germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd]
is_a: GO:0036093 ! germ cell proliferation

[Term]
id: GO:0002177
name: manchette
namespace: cellular_component
def: "A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments." [GOC:krc, PMID:15018141, PMID:22319670, PMID:24440897, PMID:26792866]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0002178
name: palmitoyltransferase complex
namespace: cellular_component
def: "A protein complex with palmitoyltransferase activity." [GOC:hjd]
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0002179
name: homodimeric serine palmitoyltransferase complex
namespace: cellular_component
def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd]
comment: This complex occurs primarily in bacteria.
is_a: GO:0002178 ! palmitoyltransferase complex

[Term]
id: GO:0002180
name: 5-lipoxygenase complex
namespace: cellular_component
def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0031965 ! nuclear membrane

[Term]
id: GO:0002181
name: cytoplasmic translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]
comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
is_a: GO:0006412 ! translation

[Term]
id: GO:0002182
name: cytoplasmic translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd]
is_a: GO:0006414 ! translational elongation
relationship: part_of GO:0002181 ! cytoplasmic translation

[Term]
id: GO:0002183
name: cytoplasmic translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]
is_a: GO:0006413 ! translational initiation
relationship: part_of GO:0002181 ! cytoplasmic translation

[Term]
id: GO:0002184
name: cytoplasmic translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd]
is_a: GO:0006415 ! translational termination
relationship: part_of GO:0002181 ! cytoplasmic translation

[Term]
id: GO:0002185
name: creatine kinase complex
namespace: cellular_component
def: "A protein complex having creatine kinase activity." [GOC:hjd]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0002186
name: cytosolic creatine kinase complex
namespace: cellular_component
def: "A dimeric protein complex having creatine kinase activity." [PMID:173175]
is_a: GO:0002185 ! creatine kinase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0002187
name: mitochondrial creatine kinase complex
namespace: cellular_component
def: "An octomeric protein complex having creatine kinase activity." [PMID:16236486]
is_a: GO:0002185 ! creatine kinase complex
is_a: GO:0098798 ! mitochondrial protein-containing complex

[Term]
id: GO:0002188
name: translation reinitiation
namespace: biological_process
def: "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792]
is_a: GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:0002189
name: ribose phosphate diphosphokinase complex
namespace: cellular_component
def: "A protein complex having ribose phosphate diphosphokinase activity." [GO:hjd, PMID:9348095]
comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits.
synonym: "phosphoribosylpyrophosphate synthetase complex" EXACT [PMID:9348095]
synonym: "PRPP synthetase complex" EXACT [PMID:9348095]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0002190
name: cap-independent translational initiation
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation." [PMID:17284590]
is_a: GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:0002191
name: cap-dependent translational initiation
namespace: biological_process
def: "The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130]
is_a: GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:0002192
name: IRES-dependent translational initiation of linear mRNA
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [PMID:17284590]
is_a: GO:0110017 ! cap-independent translational initiation of linear mRNA

[Term]
id: GO:0002193
name: MAML1-RBP-Jkappa- ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869]
synonym: "MAML1-CSL-ICN1" EXACT []
synonym: "MAML1-CSL-Notch1 complex" EXACT []
synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0002194
name: hepatocyte cell migration
namespace: biological_process
def: "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0002195
name: obsolete 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729]
comment: This term was obsoleted because this is a molecular function.
is_obsolete: true
consider: GO:0006400
consider: GO:0035597

[Term]
id: GO:0002196
name: Ser-tRNA(Ala) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)." [GOC:hjd, PMID:21285375]
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0002197
name: xanthine dehydrogenase complex
namespace: cellular_component
def: "A homodimeric protein complex having xanthine dehydrogenase activity." [GOC:hjd, PMID:8224915]
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0002198
name: obsolete S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. The transition from a cell in the S phase to the G2 phase." [GOC:hjd, GOC:mtg_cell_cycle, PMID:15161931]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0002199
name: zona pellucida receptor complex
namespace: cellular_component
def: "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732]
synonym: "sperm protein complex I" RELATED []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0002200
name: somatic diversification of immune receptors
namespace: biological_process
def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002201
name: somatic diversification of DSCAM-based immune receptors
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174]
comment: Note that this type of immune receptor may not be limited to insects.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002202
name: somatic diversification of variable lymphocyte receptors of jawless fish
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579]
comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762).
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002203
name: proteolysis by cytosolic proteases associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497).
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002204
name: somatic recombination of immunoglobulin genes involved in immune response
namespace: biological_process
def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of antibody genes during immune response" RELATED []
synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002205
name: somatic hypermutation of immunoglobulin genes involved in immune response
namespace: biological_process
def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701]
synonym: "somatic hypermutation of antibody genes during immune response" RELATED []
synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: part_of GO:0002344 ! B cell affinity maturation

[Term]
id: GO:0002206
name: gene conversion of immunoglobulin genes
namespace: biological_process
def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes" EXACT []
is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion
is_a: GO:0016445 ! somatic diversification of immunoglobulins
is_a: GO:0035822 ! gene conversion

[Term]
id: GO:0002207
name: gene conversion of immunoglobulin genes involved in immune response
namespace: biological_process
def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes during immune response" RELATED []
synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002206 ! gene conversion of immunoglobulin genes
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response

[Term]
id: GO:0002208
name: somatic diversification of immunoglobulins involved in immune response
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701]
synonym: "somatic diversification of antibodies during immune response" RELATED []
synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph]
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response

[Term]
id: GO:0002209
name: behavioral defense response
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an perceived external threat to that organism." [GO_REF:0000022, GOC:add]
synonym: "behavioural defense response" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0007610 ! behavior

[Term]
id: GO:0002210
name: behavioral response to wounding
namespace: biological_process
def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add]
synonym: "behavioural response to wounding" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0002211
name: behavioral defense response to insect
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "behavioural defense response to insect" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002213 ! defense response to insect

[Term]
id: GO:0002212
name: behavioral defense response to nematode
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883]
synonym: "behavioural defense response to nematode" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002215 ! defense response to nematode

[Term]
id: GO:0002213
name: defense response to insect
namespace: biological_process
alt_id: GO:0002214
def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "physiological defense response to insect" EXACT []
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002215
name: defense response to nematode
namespace: biological_process
alt_id: GO:0002216
def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883]
synonym: "physiological defense response to nematode" EXACT []
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002218
name: activation of innate immune response
namespace: biological_process
alt_id: GO:0002219
def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]
is_a: GO:0002253 ! activation of immune response
is_a: GO:0045089 ! positive regulation of innate immune response

[Term]
id: GO:0002220
name: innate immune response activating cell surface receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a cell surface receptor that leads to the activation of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15199967]
synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT []
synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway
is_a: GO:0002758 ! innate immune response-activating signaling pathway

[Term]
id: GO:0002221
name: pattern recognition receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "PRR signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
is_a: GO:0002758 ! innate immune response-activating signaling pathway

[Term]
id: GO:0002222
name: stimulatory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway

[Term]
id: GO:0002223
name: stimulatory C-type lectin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of C-type lectin to its receptor on the surface of a target cell, and resulting in cellular activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT []
synonym: "stimulatory Ly49 family receptor signaling pathway" NARROW [ISBN:0781735149]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway
is_a: GO:1990858 ! cellular response to lectin

[Term]
id: GO:0002224
name: toll-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
comment: Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
synonym: "TLR signaling pathway" EXACT [ISBN:0781735149]
synonym: "toll-like receptor signalling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002225
name: positive regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545]
synonym: "activation of antimicrobial peptide production" NARROW []
synonym: "antimicrobial peptide induction" EXACT []
synonym: "stimulation of antimicrobial peptide production" NARROW []
synonym: "up regulation of antimicrobial peptide production" EXACT []
synonym: "up-regulation of antimicrobial peptide production" EXACT []
synonym: "upregulation of antimicrobial peptide production" EXACT []
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002760 ! positive regulation of antimicrobial humoral response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
relationship: positively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002227
name: innate immune response in mucosa
namespace: biological_process
def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002228
name: natural killer cell mediated immunity
namespace: biological_process
def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "NK cell mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002229
name: defense response to oomycetes
namespace: biological_process
def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002230
name: positive regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "activation of antiviral response by host" NARROW []
synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of antiviral response by host" NARROW []
synonym: "up regulation of antiviral response by host" EXACT []
synonym: "up-regulation of antiviral response by host" EXACT []
synonym: "upregulation of antiviral response by host" EXACT []
is_a: GO:0050691 ! regulation of defense response to virus by host

[Term]
id: GO:0002231
name: detection of oomycetes
namespace: biological_process
def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0002232
name: leukocyte chemotaxis involved in inflammatory response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during inflammatory response" RELATED []
synonym: "leucocyte chemotaxis during inflammatory response" RELATED []
synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph]
is_a: GO:0002523 ! leukocyte migration involved in inflammatory response
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002233
name: leukocyte chemotaxis involved in immune response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during immune response" EXACT []
synonym: "leucocyte chemotaxis during immune response" EXACT []
is_a: GO:0002522 ! leukocyte migration involved in immune response
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002234
name: detection of endoplasmic reticulum overloading
namespace: biological_process
def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516]
synonym: "detection of ER overloading" EXACT []
is_a: GO:0006983 ! ER overload response
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002235
name: detection of unfolded protein
namespace: biological_process
def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470]
is_a: GO:0006986 ! response to unfolded protein
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0002236
name: detection of misfolded protein
namespace: biological_process
def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051788 ! response to misfolded protein

[Term]
id: GO:0002237
name: response to molecule of bacterial origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm]
synonym: "response to bacteria associated molecule" EXACT []
synonym: "response to bacterial associated molecule" EXACT []
synonym: "response to bacterium associated molecule" EXACT []
is_a: GO:0043207 ! response to external biotic stimulus
relationship: part_of GO:0009617 ! response to bacterium

[Term]
id: GO:0002238
name: response to molecule of fungal origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm]
synonym: "response to fungus associated molecule" EXACT []
is_a: GO:0043207 ! response to external biotic stimulus
relationship: part_of GO:0009620 ! response to fungus

[Term]
id: GO:0002239
name: response to oomycetes
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589]
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0002240
name: response to molecule of oomycetes origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm]
synonym: "response to oomycetes associated molecule" EXACT []
is_a: GO:0043207 ! response to external biotic stimulus
relationship: part_of GO:0002239 ! response to oomycetes

[Term]
id: GO:0002241
name: response to parasitic plant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862]
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0002242
name: defense response to parasitic plant
namespace: biological_process
def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002243
name: detection of parasitic plant
namespace: biological_process
def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0009602 ! detection of symbiont

[Term]
id: GO:0002244
name: hematopoietic progenitor cell differentiation
namespace: biological_process
def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]
synonym: "haematopoietic progenitor cell differentiation" EXACT []
synonym: "haemopoietic progenitor cell differentiation" EXACT []
synonym: "hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002246
name: wound healing involved in inflammatory response
namespace: biological_process
def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "healing during inflammatory response" RELATED [GOC:dph]
synonym: "inflammatory response wound healing" RELATED [GOC:dph]
is_a: GO:0042060 ! wound healing
relationship: part_of GO:0090594 ! inflammatory response to wounding

[Term]
id: GO:0002247
name: clearance of damaged tissue involved in inflammatory response wound healing
namespace: biological_process
def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0002246 ! wound healing involved in inflammatory response

[Term]
id: GO:0002248
name: connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared, as part of an inflammatory response." [GOC:jal, PMID:9639571]
synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph]
synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871]
synonym: "tissue fibrosis development" NARROW []
is_a: GO:0097709 ! connective tissue replacement
relationship: part_of GO:0002246 ! wound healing involved in inflammatory response

[Term]
id: GO:0002249
name: lymphocyte anergy
namespace: biological_process
def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002250
name: adaptive immune response
namespace: biological_process
def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "acquired immune response" EXACT [ISBN:068340007X]
synonym: "immune memory response" EXACT [GOC:add]
xref: Wikipedia:Adaptive_immune_system
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002251
name: organ or tissue specific immune response
namespace: biological_process
def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal]
synonym: "immune response in organ or tissue" EXACT []
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002252
name: immune effector process
namespace: biological_process
def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002253
name: activation of immune response
namespace: biological_process
def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002376 ! immune system process
is_a: GO:0050778 ! positive regulation of immune response

[Term]
id: GO:0002254
name: kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002526 ! acute inflammatory response
is_a: GO:0072376 ! protein activation cascade

[Term]
id: GO:0002255
name: tissue kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145]
synonym: "glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002256
name: regulation of kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:2000257 ! regulation of protein activation cascade
relationship: regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002257
name: negative regulation of kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "down regulation of kinin cascade" EXACT []
synonym: "down-regulation of kinin cascade" EXACT []
synonym: "downregulation of kinin cascade" EXACT []
synonym: "inhibition of kinin cascade" NARROW []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:2000258 ! negative regulation of protein activation cascade
relationship: negatively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002258
name: positive regulation of kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "activation of kinin cascade" NARROW []
synonym: "stimulation of kinin cascade" NARROW []
synonym: "up regulation of kinin cascade" EXACT []
synonym: "up-regulation of kinin cascade" EXACT []
synonym: "upregulation of kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:2000259 ! positive regulation of protein activation cascade
relationship: positively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002259
name: endothelial cell activation within high endothelial venule involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb]
is_a: GO:0002264 ! endothelial cell activation involved in immune response

[Term]
id: GO:0002260
name: lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
is_a: GO:0001776 ! leukocyte homeostasis

[Term]
id: GO:0002261
name: mucosal lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020]
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0002262
name: myeloid cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add]
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0002263
name: cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001775 ! cell activation
is_a: GO:0002252 ! immune effector process
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002264
name: endothelial cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0042118 ! endothelial cell activation

[Term]
id: GO:0002265
name: astrocyte activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785]
synonym: "astrocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0048143 ! astrocyte activation

[Term]
id: GO:0002266
name: follicular dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0002267
name: follicular dendritic cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789]
synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0002266 ! follicular dendritic cell activation

[Term]
id: GO:0002268
name: follicular dendritic cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002266 ! follicular dendritic cell activation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0002269
name: leukocyte activation involved in inflammatory response
namespace: biological_process
def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during inflammatory response" RELATED []
synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb]
is_a: GO:0045321 ! leukocyte activation
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002270
name: plasmacytoid dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109]
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002271
name: plasmacytoid dendritic cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109]
synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0002366 ! leukocyte activation involved in immune response

[Term]
id: GO:0002272
name: plasmacytoid dendritic cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333]
synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph]
is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response
is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation

[Term]
id: GO:0002273
name: plasmacytoid dendritic cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:0002274
name: myeloid leukocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte activation" EXACT []
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002275
name: myeloid cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002274 ! myeloid leukocyte activation
is_a: GO:0002366 ! leukocyte activation involved in immune response

[Term]
id: GO:0002276
name: basophil activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "basophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0045575 ! basophil activation
relationship: part_of GO:0002275 ! myeloid cell activation involved in immune response

[Term]
id: GO:0002277
name: myeloid dendritic cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002275 ! myeloid cell activation involved in immune response

[Term]
id: GO:0002278
name: eosinophil activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "eosinophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0043307 ! eosinophil activation

[Term]
id: GO:0002279
name: mast cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0045576 ! mast cell activation

[Term]
id: GO:0002280
name: monocyte activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245]
synonym: "monocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042117 ! monocyte activation

[Term]
id: GO:0002281
name: macrophage activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "macrophage activation during immune response" RELATED [GOC:tb]
synonym: "macrophage polarization involved in immune response" EXACT []
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0042116 ! macrophage activation
relationship: part_of GO:0002275 ! myeloid cell activation involved in immune response

[Term]
id: GO:0002282
name: microglial cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "microglial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001774 ! microglial cell activation
is_a: GO:0002281 ! macrophage activation involved in immune response

[Term]
id: GO:0002283
name: neutrophil activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "neutrophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042119 ! neutrophil activation

[Term]
id: GO:0002284
name: myeloid dendritic cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb]
is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response
is_a: GO:0043011 ! myeloid dendritic cell differentiation

[Term]
id: GO:0002285
name: lymphocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "lymphocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0002286
name: T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell activation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte activation during immune response" RELATED []
synonym: "T-cell activation during immune response" RELATED []
synonym: "T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0002287
name: alpha-beta T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte activation during immune response" RELATED []
synonym: "alpha-beta T-cell activation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0002288
name: NK T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte activation during immune response" RELATED []
synonym: "natural killer T-cell activation during immune response" RELATED []
synonym: "natural killer T-lymphocyte activation during immune response" RELATED []
synonym: "NK T cell activation during immune response" RELATED [GOC:tb]
synonym: "NK T lymphocyte activation during immune response" RELATED []
synonym: "NK T-cell activation during immune response" RELATED []
synonym: "NK T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0051132 ! NK T cell activation

[Term]
id: GO:0002289
name: NK T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte proliferation during immune response" RELATED []
synonym: "natural killer T-cell proliferation during immune response" RELATED []
synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED []
synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "NK T lymphocyte proliferation during immune response" RELATED []
synonym: "NK T-cell proliferation during immune response" RELATED []
synonym: "NK T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0001866 ! NK T cell proliferation
is_a: GO:0002288 ! NK T cell activation involved in immune response
is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response

[Term]
id: GO:0002290
name: gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523]
synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb]
synonym: "gamma-delta T lymphocyte activation during immune response" RELATED []
synonym: "gamma-delta T-cell activation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0002291
name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
is_a: GO:0002286 ! T cell activation involved in immune response

[Term]
id: GO:0002292
name: T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development involved in immune response" RELATED [GOC:add]
synonym: "T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte differentiation during immune response" RELATED []
synonym: "T-cell differentiation during immune response" RELATED []
synonym: "T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0002293
name: alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add]
synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0002292 ! T cell differentiation involved in immune response
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002294
name: CD4-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add]
synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002295
name: T-helper cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149]
synonym: "T-helper cell fate commitment" EXACT []
synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149]
synonym: "Thp lineage commitment" RELATED [ISBN:0781735149]
is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0002296
name: T-helper 1 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149]
synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149]
synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149]
synonym: "Th1 fate commitment" EXACT [ISBN:0781735149]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0002297
name: T-helper 2 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149]
synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149]
synonym: "Th2 fate commitment" EXACT [ISBN:0781735149]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0002298
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add]
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response
is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0002299
name: alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002300
name: CD8-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002301
name: CD4-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002302
name: CD8-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002303
name: gamma-delta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add]
synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph]
synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED []
synonym: "gamma-delta T-cell differentiation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response
is_a: GO:0002292 ! T cell differentiation involved in immune response
is_a: GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002304
name: gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002305
name: CD8-positive, gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002306
name: CD4-positive gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002307
name: CD8-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002308
name: CD8-positive, alpha-beta cytotoxic T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0002309
name: T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte proliferation during immune response" RELATED []
synonym: "T-cell proliferation during immune response" RELATED []
synonym: "T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0002310
name: alpha-beta T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED []
synonym: "alpha-beta T-cell proliferation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0002309 ! T cell proliferation involved in immune response
is_a: GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0002311
name: gamma-delta T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add]
synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED []
synonym: "gamma-delta T-cell proliferation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response
is_a: GO:0002309 ! T cell proliferation involved in immune response
is_a: GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0002312
name: B cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal]
synonym: "B cell activation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte activation during immune response" RELATED []
synonym: "B-cell activation during immune response" RELATED []
synonym: "B-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0002313
name: mature B cell differentiation involved in immune response
namespace: biological_process
def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B cell development involved in immune response" RELATED [GOC:add]
synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb]
synonym: "mature B lymphocyte differentiation during immune response" RELATED []
synonym: "mature B-cell differentiation during immune response" RELATED []
synonym: "mature B-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0002335 ! mature B cell differentiation

[Term]
id: GO:0002314
name: germinal center B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "germinal center B cell development" RELATED [GOC:add]
synonym: "germinal center B lymphocyte differentiation" EXACT []
synonym: "germinal center B-cell differentiation" EXACT []
synonym: "germinal center B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002315
name: marginal zone B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "marginal zone B cell development" RELATED [GOC:add]
synonym: "marginal zone B lymphocyte differentiation" EXACT []
synonym: "marginal zone B-cell differentiation" EXACT []
synonym: "marginal zone B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002316
name: follicular B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "follicular B cell development" RELATED [GOC:add]
synonym: "follicular B lymphocyte differentiation" EXACT []
synonym: "follicular B-cell differentiation" EXACT []
synonym: "follicular B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002317
name: plasma cell differentiation
namespace: biological_process
def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "plasma cell development" RELATED [GOC:add]
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002318
name: myeloid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation

[Term]
id: GO:0002319
name: memory B cell differentiation
namespace: biological_process
def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "memory B cell development" RELATED [GOC:add]
synonym: "memory B lymphocyte differentiation" EXACT []
synonym: "memory B-cell differentiation" EXACT []
synonym: "memory B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response
is_a: GO:0090715 ! immunological memory formation process

[Term]
id: GO:0002320
name: lymphoid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation

[Term]
id: GO:0002321
name: natural killer cell progenitor differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002322
name: B cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal]
synonym: "B cell proliferation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte proliferation during immune response" RELATED []
synonym: "B-cell proliferation during immune response" RELATED []
synonym: "B-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002323
name: natural killer cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell activation during immune response" RELATED [GOC:tb]
synonym: "NK cell activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0030101 ! natural killer cell activation
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0002324
name: natural killer cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "NK cell proliferation during immune response" RELATED []
is_a: GO:0001787 ! natural killer cell proliferation
is_a: GO:0002285 ! lymphocyte activation involved in immune response

[Term]
id: GO:0002325
name: natural killer cell differentiation involved in immune response
namespace: biological_process
def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "NK cell differentiation during immune response" RELATED []
is_a: GO:0001779 ! natural killer cell differentiation
is_a: GO:0002285 ! lymphocyte activation involved in immune response

[Term]
id: GO:0002326
name: B cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149]
synonym: "B lymphocyte lineage commitment" EXACT []
synonym: "B-cell lineage commitment" EXACT []
synonym: "B-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002327
name: immature B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "immature B cell development" RELATED [GOC:add]
synonym: "immature B lymphocyte differentiation" EXACT []
synonym: "immature B-cell differentiation" EXACT []
synonym: "immature B-lymphocyte differentiation" EXACT []
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002328
name: pro-B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149]
synonym: "pro-B cell development" RELATED [GOC:add]
synonym: "pro-B lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002329
name: pre-B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "pre-B cell development" RELATED [GOC:add]
synonym: "pre-B lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002330
name: pre-B cell receptor expression
namespace: biological_process
def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell." [GOC:add, GOC:jal, PMID:15263090, PMID:22949502, PMID:9834086]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002331
name: pre-B cell allelic exclusion
namespace: biological_process
def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:add, GOC:jal, ISBN:0781735149]
synonym: "pre-B lymphocyte allelic exclusion" EXACT []
is_a: GO:0010468 ! regulation of gene expression
relationship: part_of GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002332
name: transitional stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "transitional stage B cell development" RELATED [GOC:add]
synonym: "transitional stage B lymphocyte differentiation" EXACT []
synonym: "transitional stage B-cell differentiation" EXACT []
synonym: "transitional stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002333
name: transitional one stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T1 stage B cell differentiation" EXACT []
synonym: "transitional one stage B cell development" RELATED [GOC:add]
synonym: "transitional one stage B lymphocyte differentiation" EXACT []
synonym: "transitional one stage B-cell differentiation" EXACT []
synonym: "transitional one stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002334
name: transitional two stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T2 stage B cell differentiation" EXACT []
synonym: "transitional two stage B cell development" RELATED [GOC:add]
synonym: "transitional two stage B lymphocyte differentiation" EXACT []
synonym: "transitional two stage B-cell differentiation" EXACT []
synonym: "transitional two stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002335
name: mature B cell differentiation
namespace: biological_process
def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B lymphocyte differentiation" EXACT []
synonym: "mature B-cell differentiation" EXACT []
synonym: "mature B-lymphocyte differentiation" EXACT []
synonym: "mature cell development" RELATED [GOC:add]
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002336
name: B-1 B cell lineage commitment
namespace: biological_process
def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149]
synonym: "B-1 B lymphocyte lineage commitment" EXACT []
synonym: "B-1 B-cell lineage commitment" EXACT []
synonym: "B-1 B-lymphocyte lineage commitment" EXACT []
is_a: GO:0002326 ! B cell lineage commitment
relationship: part_of GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002337
name: B-1a B cell differentiation
namespace: biological_process
def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1a B cell development" RELATED [GOC:add]
synonym: "B-1a B lymphocyte differentiation" EXACT []
synonym: "B-1a B-cell differentiation" EXACT []
synonym: "B-1a B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002338
name: B-1b B cell differentiation
namespace: biological_process
def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1b B cell development" RELATED [GOC:add]
synonym: "B-1b B lymphocyte differentiation" EXACT []
synonym: "B-1b B-cell differentiation" EXACT []
synonym: "B-1b B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002339
name: B cell selection
namespace: biological_process
def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal]
synonym: "B lymphocyte selection" EXACT []
synonym: "B-cell selection" EXACT []
synonym: "B-lymphocyte selection" EXACT []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002340
name: central B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte selection" EXACT []
synonym: "central B-cell selection" EXACT []
synonym: "central B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002341
name: central B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte anergy" EXACT []
synonym: "central B-cell anergy" EXACT []
synonym: "central B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002342
name: central B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis]
synonym: "central B lymphocyte deletion" EXACT []
synonym: "central B-cell deletion" EXACT []
synonym: "central B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
is_a: GO:0010623 ! programmed cell death involved in cell development
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002343
name: peripheral B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte selection" EXACT []
synonym: "peripheral B-cell selection" EXACT []
synonym: "peripheral B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002344
name: B cell affinity maturation
namespace: biological_process
def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte affinity maturation" EXACT []
synonym: "B-cell affinity maturation" EXACT []
synonym: "B-lymphocyte affinity maturation" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response

[Term]
id: GO:0002345
name: peripheral B cell receptor editing
namespace: biological_process
def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal]
synonym: "peripheral B lymphocyte receptor editing" EXACT []
synonym: "peripheral B-cell receptor editing" EXACT []
synonym: "peripheral B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002346
name: B cell positive selection
namespace: biological_process
def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal]
synonym: "B lymphocyte positive selection" EXACT []
synonym: "B-cell positive selection" EXACT []
synonym: "B-lymphocyte positive selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002347
name: response to tumor cell
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002348
name: central B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "central B lymphocyte positive selection" EXACT []
synonym: "central B-cell positive selection" EXACT []
synonym: "central B-lymphocyte positive selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002349
name: histamine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "histamine production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002350
name: peripheral B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "peripheral B lymphocyte positive selection" EXACT []
synonym: "peripheral B-cell positive selection" EXACT []
synonym: "peripheral B-lymphocyte positive selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002351
name: serotonin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "serotonin production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002352
name: B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal]
synonym: "B lymphocyte negative selection" EXACT []
synonym: "B-cell negative selection" EXACT []
synonym: "B-lymphocyte negative selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002353
name: plasma kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002354
name: central B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte negative selection" EXACT []
synonym: "central B-cell negative selection" EXACT []
synonym: "central B-lymphocyte negative selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002355
name: detection of tumor cell
namespace: biological_process
def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002356
name: peripheral B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte negative selection" EXACT []
synonym: "peripheral B-cell negative selection" EXACT []
synonym: "peripheral B-lymphocyte negative selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002357
name: defense response to tumor cell
namespace: biological_process
def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002358
name: B cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal]
synonym: "B lymphocyte homeostatic proliferation" EXACT []
synonym: "B-cell homeostatic proliferation" EXACT []
synonym: "B-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation
relationship: part_of GO:0042592 ! homeostatic process

[Term]
id: GO:0002359
name: B-1 B cell proliferation
namespace: biological_process
def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal]
synonym: "B-1 B lymphocyte proliferation" EXACT []
synonym: "B-1 B-cell proliferation" EXACT []
synonym: "B-1 B-lymphocyte proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002360
name: T cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte lineage commitment" EXACT []
synonym: "T-cell lineage commitment" EXACT []
synonym: "T-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002361
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002362
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT []
is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0002363
name: alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "alpha-beta T-cell lineage commitment" EXACT []
synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002364
name: NK T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149]
synonym: "natural killer T lymphocyte lineage commitment" EXACT []
synonym: "natural killer T-cell lineage commitment" EXACT []
synonym: "natural killer T-lymphocyte lineage commitment" EXACT []
synonym: "NK T lymphocyte lineage commitment" EXACT []
synonym: "NK T-cell lineage commitment" EXACT []
synonym: "NK T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002363 ! alpha-beta T cell lineage commitment
relationship: part_of GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0002365
name: gamma-delta T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149]
synonym: "gamma-delta T lymphocyte lineage commitment" EXACT []
synonym: "gamma-delta T-cell lineage commitment" EXACT []
synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002366
name: leukocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during immune response" RELATED []
synonym: "leucocyte activation during immune response" RELATED []
synonym: "leukocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002367
name: cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002374
alt_id: GO:0002375
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cytokine biosynthetic process involved in immune response" NARROW []
synonym: "cytokine production during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion involved in immune response" RELATED []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002368
name: B cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "B lymphocyte cytokine production" EXACT []
synonym: "B-cell cytokine production" EXACT []
synonym: "B-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002369
name: T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002370
name: natural killer cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "NK cell cytokine production" EXACT []
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002372
name: myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002371 ! dendritic cell cytokine production
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0002373
name: plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0002377
name: immunoglobulin production
namespace: biological_process
alt_id: GO:0002378
alt_id: GO:0048305
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production" EXACT []
synonym: "immunoglobulin biosynthetic process" NARROW []
synonym: "immunoglobulin secretion" NARROW []
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002381
name: immunoglobulin production involved in immunoglobulin-mediated immune response
namespace: biological_process
alt_id: GO:0002379
alt_id: GO:0002380
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:9185563]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production during immune response" RELATED []
synonym: "antibody secretion during immune response" RELATED []
synonym: "immunoglobulin biosynthetic process involved in immune response" NARROW []
synonym: "immunoglobulin production during immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immunoglobulin mediated immune response" EXACT []
synonym: "immunoglobulin secretion involved in immune response" NARROW []
is_a: GO:0002377 ! immunoglobulin production
relationship: part_of GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002382
name: regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002383
name: immune response in brain or nervous system
namespace: biological_process
def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002384
name: hepatic immune response
namespace: biological_process
def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002385
name: mucosal immune response
namespace: biological_process
alt_id: GO:0002386
alt_id: GO:0002422
def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
synonym: "immune response in MALT" NARROW []
synonym: "immune response in mucosal-associated lymphoid tissue" NARROW []
synonym: "immune response in urogenital tract" NARROW []
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002387
name: immune response in gut-associated lymphoid tissue
namespace: biological_process
def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149]
synonym: "immune response in GALT" EXACT []
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002388
name: immune response in Peyer's patch
namespace: biological_process
def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149]
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue

[Term]
id: GO:0002389
name: tolerance induction in Peyer's patch
namespace: biological_process
def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149]
is_a: GO:0002388 ! immune response in Peyer's patch
is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue

[Term]
id: GO:0002391
name: platelet activating factor production involved in inflammatory response
namespace: biological_process
alt_id: GO:0002390
alt_id: GO:0002392
alt_id: GO:0002535
def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "platelet activating factor production" RELATED []
synonym: "platelet activating factor production involved in acute inflammatory response" NARROW []
synonym: "platelet activating factor secretion" NARROW []
synonym: "platelet activating factor secretion involved in acute inflammatory response" NARROW []
synonym: "platelet activating factor secretion involved in inflammatory response" NARROW []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002393
name: lysosomal enzyme production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add]
synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD []
synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002394
name: tolerance induction in gut-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149]
synonym: "oral tolerance" RELATED []
synonym: "tolerance induction in GALT" EXACT []
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue

[Term]
id: GO:0002395
name: immune response in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149]
synonym: "immune response in NALT" EXACT []
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue

[Term]
id: GO:0002396
name: MHC protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0002397
name: MHC class I protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002398
name: MHC class Ib protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002399
name: MHC class II protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002400
name: tolerance induction in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149]
synonym: "nasal tolerance" RELATED []
synonym: "tolerance induction in NALT" EXACT []
is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue
is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue

[Term]
id: GO:0002401
name: tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149]
synonym: "tolerance induction in MALT" EXACT []
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002402
name: B cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149]
synonym: "B cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002403
name: T cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]
synonym: "T cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002404
name: antigen sampling in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746]
synonym: "antigen sampling in MALT" EXACT []
synonym: "antigen transport in MALT" RELATED []
synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002385 ! mucosal immune response

[Term]
id: GO:0002405
name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746]
synonym: "antigen sampling by dendritic cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue
relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002406
name: antigen sampling by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763]
synonym: "antigen sampling by M cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue

[Term]
id: GO:0002407
name: dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0036336 ! dendritic cell migration

[Term]
id: GO:0002408
name: myeloid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0002407 ! dendritic cell chemotaxis
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0002409
name: Langerhans cell chemotaxis
namespace: biological_process
def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601]
is_a: GO:0002408 ! myeloid dendritic cell chemotaxis

[Term]
id: GO:0002410
name: plasmacytoid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331]
is_a: GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:0002411
name: T cell tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002413 ! tolerance induction to tumor cell
is_a: GO:0002424 ! T cell mediated immune response to tumor cell
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002412
name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411]
synonym: "antigen transcytosis by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT []
is_a: GO:0045056 ! transcytosis
relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue

[Term]
id: GO:0002413
name: tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add]
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002414
name: immunoglobulin transcytosis in epithelial cells
namespace: biological_process
def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]
is_a: GO:0045056 ! transcytosis

[Term]
id: GO:0002415
name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
namespace: biological_process
def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]
synonym: "antibody transcytosis mediated by pIgR" EXACT []
synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells
relationship: part_of GO:0002385 ! mucosal immune response

[Term]
id: GO:0002416
name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
namespace: biological_process
def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X]
synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT []
synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells

[Term]
id: GO:0002417
name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis

[Term]
id: GO:0002418
name: immune response to tumor cell
namespace: biological_process
def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002419
name: T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001913 ! T cell mediated cytotoxicity
is_a: GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002420
name: natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell
is_a: GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0002421
name: B cell antigen processing and presentation following pinocytosis
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530]
synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002423
name: natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002424
name: T cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells.
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002425
name: tolerance induction in urogenital tract
namespace: biological_process
def: "Tolerance induction taking place in the urogenital tract." [GOC:jal]
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002426
name: immunoglobulin production in mucosal tissue
namespace: biological_process
def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production in mucosal tissue" EXACT []
is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response
relationship: part_of GO:0002385 ! mucosal immune response

[Term]
id: GO:0002427
name: mucosal tolerance induction
namespace: biological_process
def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002428
name: antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678]
synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002429
name: immune response-activating cell surface receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell, leading to the activation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT []
synonym: "immune response-activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002757 ! immune response-activating signaling pathway
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002430
name: complement receptor mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "complement receptor mediated signalling pathway" EXACT []
synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002431
name: Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT []
synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002432
name: granuloma formation
namespace: biological_process
def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X]
is_a: GO:0002252 ! immune effector process
relationship: part_of GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002433
name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, ISBN:0781735149]
synonym: "immune response-regulating cell surface receptor signalling pathway involved in phagocytosis" EXACT [GOC:mah]
synonym: "phagocytosis triggered by activation of immune response cell surface activating receptor" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0002434
name: immune complex clearance
namespace: biological_process
def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, ISBN:068340007X]
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002435
name: immune complex clearance by erythrocytes
namespace: biological_process
def: "The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation." [GOC:add, PMID:11414352, PMID:24022490]
synonym: "immune complex clearance by RBCs" EXACT [CL:0000232]
synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232]
xref: Wikipedia:Immune_complex
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002436
name: immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149]
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002437
name: inflammatory response to antigenic stimulus
namespace: biological_process
def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149]
is_a: GO:0006954 ! inflammatory response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002438
name: acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002439
name: chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149]
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0002376 ! immune system process
is_a: GO:0010467 ! gene expression

[Term]
id: GO:0002441
name: histamine secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "histamine secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001821 ! histamine secretion
is_a: GO:0046879 ! hormone secretion
relationship: part_of GO:0002349 ! histamine production involved in inflammatory response

[Term]
id: GO:0002442
name: serotonin secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb]
synonym: "serotonin secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001820 ! serotonin secretion
relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response

[Term]
id: GO:0002443
name: leukocyte mediated immunity
namespace: biological_process
alt_id: GO:0019723
alt_id: GO:0042087
def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immune response" RELATED []
synonym: "cellular immune response" RELATED []
synonym: "immune cell effector process" EXACT []
synonym: "immune cell mediated immunity" EXACT []
synonym: "leucocyte immune effector process" EXACT []
synonym: "leucocyte mediated immunity" EXACT []
synonym: "leukocyte immune effector process" EXACT []
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002444
name: myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte immune effector process" EXACT []
synonym: "myeloid leucocyte mediated immunity" EXACT []
synonym: "myeloid leukocyte immune effector process" EXACT []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002445
name: type II hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149]
xref: Wikipedia:Type_II_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002446
name: neutrophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002447
name: eosinophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002448
name: mast cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002449
name: lymphocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002450
name: B cell antigen processing and presentation
namespace: biological_process
def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation" EXACT []
synonym: "B-cell antigen processing and presentation" EXACT []
synonym: "B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002451
name: peripheral B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149]
synonym: "peripheral B lymphocyte tolerance induction" EXACT []
synonym: "peripheral B-cell tolerance induction" EXACT []
synonym: "peripheral B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002514 ! B cell tolerance induction
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002452
name: B cell receptor editing
namespace: biological_process
def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte receptor editing" EXACT []
synonym: "B-cell receptor editing" EXACT []
synonym: "B-lymphocyte receptor editing" EXACT []
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002453
name: peripheral B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149]
synonym: "peripheral B lymphocyte anergy" EXACT []
synonym: "peripheral B-cell anergy" EXACT []
synonym: "peripheral B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002454
name: peripheral B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "peripheral B lymphocyte deletion" EXACT []
synonym: "peripheral B-cell deletion" EXACT []
synonym: "peripheral B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002455
name: humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "circulating antibody mediated immune response" EXACT []
synonym: "circulating immunoglobulin mediated immune response" EXACT []
synonym: "humoral defence mechanism" RELATED []
synonym: "humoral immune response mediated by circulating antibody" EXACT []
is_a: GO:0006959 ! humoral immune response
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002456
name: T cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
synonym: "T lymphocyte mediated immunity" EXACT []
synonym: "T-cell mediated immunity" EXACT []
synonym: "T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002457
name: T cell antigen processing and presentation
namespace: biological_process
def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]
synonym: "T lymphocyte antigen processing and presentation" EXACT []
synonym: "T-cell antigen processing and presentation" EXACT []
synonym: "T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002458
name: peripheral T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149]
synonym: "peripheral T lymphocyte tolerance induction" EXACT []
synonym: "peripheral T-cell tolerance induction" EXACT []
synonym: "peripheral T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002459
name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
namespace: biological_process
def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579]
synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT []
synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT []
synonym: "adaptive immune response in jawless fish" EXACT []
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002461
name: tolerance induction dependent upon immune response
namespace: biological_process
def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
synonym: "immune response-dependent tolerance induction" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002462
name: tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002463
name: central tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002508 ! central tolerance induction

[Term]
id: GO:0002464
name: peripheral tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002465
name: peripheral tolerance induction
namespace: biological_process
def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002466
name: peripheral tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149]
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002467
name: germinal center formation
namespace: biological_process
def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, ISBN:081533642X]
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0002468
name: dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002469
name: myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002470
name: plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002471
name: monocyte antigen processing and presentation
namespace: biological_process
def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002472
name: macrophage antigen processing and presentation
namespace: biological_process
def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002473
name: non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002474
name: antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002475
name: antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002476
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen

[Term]
id: GO:0002477
name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen

[Term]
id: GO:0002478
name: antigen processing and presentation of exogenous peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]
synonym: "exogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002479
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002480
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002481
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002482
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002483
name: antigen processing and presentation of endogenous peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]
synonym: "endogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002484
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002485
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002486
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002487
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002488
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002489
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002490
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002491
name: antigen processing and presentation of endogenous peptide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338]
synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002492
name: peptide antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002493
name: lipid antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0065005 ! protein-lipid complex assembly
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002494
name: lipid antigen transport
namespace: biological_process
def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0006869 ! lipid transport
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002495
name: antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002496
name: proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
is_a: GO:0051603 ! proteolysis involved in protein catabolic process
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002497
name: proteasomal proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002498
name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT []
synonym: "ER proteolysis associated with antigen processing and presentation" EXACT []
synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002499
name: proteolysis within endosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002500
name: proteolysis within lysosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002501
name: peptide antigen assembly with MHC protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0002396 ! MHC protein complex assembly
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002502
name: peptide antigen assembly with MHC class I protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002397 ! MHC class I protein complex assembly
relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002503
name: peptide antigen assembly with MHC class II protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002399 ! MHC class II protein complex assembly
relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]
synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002505
name: antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240]
synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002507
name: tolerance induction
namespace: biological_process
def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002508
name: central tolerance induction
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002509
name: central tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922]
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002510
name: central B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte tolerance induction" EXACT []
synonym: "central B-cell tolerance induction" EXACT []
synonym: "central B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002511
name: central B cell receptor editing
namespace: biological_process
def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte receptor editing" EXACT []
synonym: "central B-cell receptor editing" EXACT []
synonym: "central B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002512
name: central T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149]
synonym: "central T lymphocyte tolerance induction" EXACT []
synonym: "central T-cell tolerance induction" EXACT []
synonym: "central T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002513
name: tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002514
name: B cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922]
synonym: "B lymphocyte tolerance induction" EXACT []
synonym: "B-cell tolerance induction" EXACT []
synonym: "B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002515
name: B cell anergy
namespace: biological_process
def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte anergy" EXACT []
synonym: "B-cell anergy" EXACT []
synonym: "B-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002516
name: B cell deletion
namespace: biological_process
def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte deletion" EXACT []
synonym: "B-cell deletion" EXACT []
synonym: "B-lymphocyte deletion" EXACT []
is_a: GO:0001783 ! B cell apoptotic process
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002517
name: T cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]
synonym: "T lymphocyte tolerance induction" EXACT []
synonym: "T-cell tolerance induction" EXACT []
synonym: "T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002518
name: lymphocyte chemotaxis across high endothelial venule
namespace: biological_process
def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201]
is_a: GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0002519
name: natural killer cell tolerance induction
namespace: biological_process
def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094]
synonym: "NK cell tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002520
name: immune system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]
subset: goslim_drosophila
is_a: GO:0002376 ! immune system process
is_a: GO:0048731 ! system development

[Term]
id: GO:0002521
name: leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]
synonym: "immune cell differentiation" EXACT []
synonym: "leucocyte differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002522
name: leukocyte migration involved in immune response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during immune response" EXACT []
synonym: "immune cell trafficking during immune response" EXACT []
synonym: "leucocyte migration during immune response" EXACT []
synonym: "leucocyte trafficking during immune response" EXACT []
synonym: "leukocyte trafficking during immune response" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0050900 ! leukocyte migration
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002523
name: leukocyte migration involved in inflammatory response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during inflammatory response" RELATED []
synonym: "immune cell trafficking during inflammatory response" RELATED []
synonym: "leucocyte migration during inflammatory response" RELATED []
synonym: "leucocyte trafficking during inflammatory response" RELATED []
synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph]
synonym: "leukocyte trafficking during inflammatory response" RELATED []
is_a: GO:0050900 ! leukocyte migration
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002524
name: hypersensitivity
namespace: biological_process
def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149]
synonym: "hypersensitivity response" RELATED [ISBN:0781735149]
xref: Wikipedia:Hypersensitivity
is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002525
name: acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002526
name: acute inflammatory response
namespace: biological_process
def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002527
name: vasodilation involved in acute inflammatory response
namespace: biological_process
def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal]
synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph]
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002528
name: regulation of vascular permeability involved in acute inflammatory response
namespace: biological_process
def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal]
synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph]
is_a: GO:0043114 ! regulation of vascular permeability
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002529
name: regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
is_a: GO:0002256 ! regulation of kinin cascade
relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002530
name: regulation of systemic arterial blood pressure involved in acute-phase response
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X]
synonym: "blood pressure regulation during acute phase response" RELATED []
synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002531
name: regulation of heart contraction involved in acute-phase response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430]
synonym: "regulation of cardiac contraction during acute phase response" RELATED []
synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb]
is_a: GO:0008016 ! regulation of heart contraction
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002532
name: production of molecular mediator involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "production of cellular mediator of acute inflammation" RELATED []
synonym: "production of molecular mediator involved in acute inflammatory response" BROAD []
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002533
name: lysosomal enzyme secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response." [GOC:jal, PMID:11836514]
synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah]
synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD []
synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT []
is_a: GO:0033299 ! secretion of lysosomal enzymes
relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response

[Term]
id: GO:0002534
name: cytokine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
subset: gocheck_do_not_annotate
synonym: "cytokine production involved in acute inflammatory response" BROAD []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002536
name: respiratory burst involved in inflammatory response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "oxidative burst during acute inflammatory response" BROAD []
synonym: "production of reactive oxygen species during acute inflammatory response" BROAD []
synonym: "respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
is_a: GO:0002679 ! respiratory burst involved in defense response

[Term]
id: GO:0002537
name: nitric oxide production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of nitric oxide involved in acute inflammatory response" BROAD []
synonym: "production of nitric oxide involved in inflammatory response" EXACT []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002538
name: arachidonate metabolite production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "arachidonic acid metabolite production involved in inflammatory response" EXACT []
synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD []
synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002539
name: prostaglandin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "prostaglandin production involved in acute inflammatory response" BROAD []
is_a: GO:0002538 ! arachidonate metabolite production involved in inflammatory response

[Term]
id: GO:0002540
name: leukotriene production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "leukotriene production involved in acute inflammatory response" BROAD []
is_a: GO:0002538 ! arachidonate metabolite production involved in inflammatory response

[Term]
id: GO:0002541
name: activation of plasma proteins involved in acute inflammatory response
namespace: biological_process
def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149]
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002542
name: Factor XII activation
namespace: biological_process
def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871]
synonym: "Hageman factor activation" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0010954 ! positive regulation of protein processing
relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response

[Term]
id: GO:0002543
name: activation of blood coagulation via clotting cascade
namespace: biological_process
def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149]
synonym: "activation of clotting cascade" EXACT []
is_a: GO:0030194 ! positive regulation of blood coagulation
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002544
name: chronic inflammatory response
namespace: biological_process
def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002545
name: chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal]
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002546
name: negative regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW []
synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002547
name: positive regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "activation of tissue kallikrein-kinin cascade" NARROW []
synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT []
synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW []
synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002548
name: monocyte chemotaxis
namespace: biological_process
def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0071674 ! mononuclear cell migration
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0002549
name: negative regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002550
name: positive regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "activation of plasma kallikrein-kinin cascade" NARROW []
synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW []
synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002551
name: mast cell chemotaxis
namespace: biological_process
def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097531 ! mast cell migration

[Term]
id: GO:0002552
name: serotonin secretion by mast cell
namespace: biological_process
def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by mast cell" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002553
name: histamine secretion by mast cell
namespace: biological_process
def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002554
name: serotonin secretion by platelet
namespace: biological_process
def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by platelet" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002555
name: histamine secretion by platelet
namespace: biological_process
def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002556
name: serotonin secretion by basophil
namespace: biological_process
def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by basophil" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002557
name: histamine secretion by basophil
namespace: biological_process
def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002558
name: type I hypersensitivity mediated by mast cells
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
is_a: GO:0002448 ! mast cell mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002559
name: type I hypersensitivity mediated by basophils
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
is_a: GO:0002560 ! basophil mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002560
name: basophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002561
name: basophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149]
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002276 ! basophil activation involved in immune response
relationship: part_of GO:0002560 ! basophil mediated immunity

[Term]
id: GO:0002562
name: somatic diversification of immune receptors via germline recombination within a single locus
namespace: biological_process
def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002563
name: somatic diversification of immune receptors via alternate splicing
namespace: biological_process
def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002564
name: alternate splicing of immunoglobulin genes
namespace: biological_process
def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563]
synonym: "alternate splicing of antibody genes" EXACT []
is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0002565
name: somatic diversification of immune receptors via gene conversion
namespace: biological_process
def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002566
name: somatic diversification of immune receptors via somatic mutation
namespace: biological_process
def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002567
name: somatic diversification of FREP-based immune receptors
namespace: biological_process
def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575]
comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002568
name: somatic diversification of T cell receptor genes
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of TCR genes" EXACT []
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002569
name: somatic diversification of immune receptors by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002570
name: somatic diversification of immunoglobulin genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of antibody genes by N region addition" EXACT []
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002571
name: somatic diversification of T cell receptor genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of TCR genes by N region addition" EXACT []
is_a: GO:0002568 ! somatic diversification of T cell receptor genes
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments

[Term]
id: GO:0002572
name: pro-T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149]
synonym: "pro-T lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]
synonym: "myeloid leucocyte differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002574
name: thrombocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add]
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002575
name: basophil chemotaxis
namespace: biological_process
def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027]
is_a: GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0002576
name: platelet degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add]
synonym: "platelet exocytosis" EXACT []
is_a: GO:0045055 ! regulated exocytosis
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0002577
name: regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
relationship: regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002578
name: negative regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "down regulation of antigen processing and presentation" EXACT []
synonym: "down-regulation of antigen processing and presentation" EXACT []
synonym: "downregulation of antigen processing and presentation" EXACT []
synonym: "inhibition of antigen processing and presentation" NARROW []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002683 ! negative regulation of immune system process
relationship: negatively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002579
name: positive regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "activation of antigen processing and presentation" NARROW []
synonym: "stimulation of antigen processing and presentation" NARROW []
synonym: "up regulation of antigen processing and presentation" EXACT []
synonym: "up-regulation of antigen processing and presentation" EXACT []
synonym: "upregulation of antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002684 ! positive regulation of immune system process
relationship: positively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002580
name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002581
name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002582
name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002583
name: regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002584
name: negative regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002585
name: positive regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002586
name: regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002587
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002588
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002589
name: regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002590
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002591
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002592
name: regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002593
name: negative regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002594
name: positive regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002595
name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002596
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002597
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002598
name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002599
name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002600
name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002601
name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002602
name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002603
name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002607
name: regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002608
name: negative regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002609
name: positive regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002610
name: regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002611
name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002612
name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002613
name: regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002614
name: negative regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "down regulation of monocyte antigen processing and presentation" EXACT []
synonym: "down-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "downregulation of monocyte antigen processing and presentation" EXACT []
synonym: "inhibition of monocyte antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002615
name: positive regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "activation of monocyte antigen processing and presentation" NARROW []
synonym: "stimulation of monocyte antigen processing and presentation" NARROW []
synonym: "up regulation of monocyte antigen processing and presentation" EXACT []
synonym: "up-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "upregulation of monocyte antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002616
name: regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002617
name: negative regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "down regulation of macrophage antigen processing and presentation" EXACT []
synonym: "down-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "downregulation of macrophage antigen processing and presentation" EXACT []
synonym: "inhibition of macrophage antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002618
name: positive regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "activation of macrophage antigen processing and presentation" NARROW []
synonym: "stimulation of macrophage antigen processing and presentation" NARROW []
synonym: "up regulation of macrophage antigen processing and presentation" EXACT []
synonym: "up-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "upregulation of macrophage antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002619
name: regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002620
name: negative regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002621
name: positive regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002622
name: regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of B-cell antigen processing and presentation" EXACT []
synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002712 ! regulation of B cell mediated immunity
relationship: regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002623
name: negative regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of B cell antigen processing and presentation" EXACT []
synonym: "down-regulation of B cell antigen processing and presentation" EXACT []
synonym: "downregulation of B cell antigen processing and presentation" EXACT []
synonym: "inhibition of B cell antigen processing and presentation" NARROW []
synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of B-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002624
name: positive regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "activation of B cell antigen processing and presentation" NARROW []
synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of B-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of B cell antigen processing and presentation" NARROW []
synonym: "up regulation of B cell antigen processing and presentation" EXACT []
synonym: "up-regulation of B cell antigen processing and presentation" EXACT []
synonym: "upregulation of B cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002625
name: regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of T-cell antigen processing and presentation" EXACT []
synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002709 ! regulation of T cell mediated immunity
relationship: regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of T cell antigen processing and presentation" EXACT []
synonym: "down-regulation of T cell antigen processing and presentation" EXACT []
synonym: "downregulation of T cell antigen processing and presentation" EXACT []
synonym: "inhibition of T cell antigen processing and presentation" NARROW []
synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of T-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "activation of T cell antigen processing and presentation" NARROW []
synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of T-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of T cell antigen processing and presentation" NARROW []
synonym: "up regulation of T cell antigen processing and presentation" EXACT []
synonym: "up-regulation of T cell antigen processing and presentation" EXACT []
synonym: "upregulation of T cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002628
name: regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process
relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002629
name: negative regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1903051 ! negative regulation of proteolysis involved in protein catabolic process
relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002630
name: positive regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:1903052 ! positive regulation of proteolysis involved in protein catabolic process
relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002631
name: regulation of granuloma formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002697 ! regulation of immune effector process
relationship: regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002632
name: negative regulation of granuloma formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "down regulation of granuloma formation" EXACT []
synonym: "down-regulation of granuloma formation" EXACT []
synonym: "downregulation of granuloma formation" EXACT []
synonym: "inhibition of granuloma formation" NARROW []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002698 ! negative regulation of immune effector process
relationship: negatively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002633
name: positive regulation of granuloma formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "activation of granuloma formation" NARROW []
synonym: "stimulation of granuloma formation" NARROW []
synonym: "up regulation of granuloma formation" EXACT []
synonym: "up-regulation of granuloma formation" EXACT []
synonym: "upregulation of granuloma formation" EXACT []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002699 ! positive regulation of immune effector process
relationship: positively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002634
name: regulation of germinal center formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002635
name: negative regulation of germinal center formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "down regulation of germinal center formation" EXACT []
synonym: "down-regulation of germinal center formation" EXACT []
synonym: "downregulation of germinal center formation" EXACT []
synonym: "inhibition of germinal center formation" NARROW []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002636
name: positive regulation of germinal center formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "activation of germinal center formation" NARROW []
synonym: "stimulation of germinal center formation" NARROW []
synonym: "up regulation of germinal center formation" EXACT []
synonym: "up-regulation of germinal center formation" EXACT []
synonym: "upregulation of germinal center formation" EXACT []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002637
name: regulation of immunoglobulin production
namespace: biological_process
alt_id: GO:0002640
alt_id: GO:0051023
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "regulation of antibody production" EXACT []
synonym: "regulation of immunoglobulin biosynthetic process" NARROW []
synonym: "regulation of immunoglobulin secretion" NARROW []
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002638
name: negative regulation of immunoglobulin production
namespace: biological_process
alt_id: GO:0002641
alt_id: GO:0051025
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "down regulation of immunoglobulin production" EXACT []
synonym: "down-regulation of immunoglobulin production" EXACT []
synonym: "downregulation of immunoglobulin production" EXACT []
synonym: "inhibition of immunoglobulin production" NARROW []
synonym: "negative regulation of immunoglobulin biosynthetic process" NARROW []
synonym: "negative regulation of immunoglobulin secretion" NARROW []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
relationship: negatively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002639
name: positive regulation of immunoglobulin production
namespace: biological_process
alt_id: GO:0002642
alt_id: GO:0051024
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "activation of immunoglobulin production" NARROW []
synonym: "positive regulation of immunoglobulin biosynthetic process" NARROW []
synonym: "positive regulation of immunoglobulin secretion" NARROW []
synonym: "stimulation of immunoglobulin production" NARROW []
synonym: "up regulation of immunoglobulin production" EXACT []
synonym: "up-regulation of immunoglobulin production" EXACT []
synonym: "upregulation of immunoglobulin production" EXACT []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
relationship: positively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002643
name: regulation of tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
relationship: regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002644
name: negative regulation of tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "down regulation of tolerance induction" EXACT []
synonym: "down-regulation of tolerance induction" EXACT []
synonym: "downregulation of tolerance induction" EXACT []
synonym: "inhibition of tolerance induction" NARROW []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002645
name: positive regulation of tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "activation of tolerance induction" NARROW []
synonym: "stimulation of tolerance induction" NARROW []
synonym: "up regulation of tolerance induction" EXACT []
synonym: "up-regulation of tolerance induction" EXACT []
synonym: "upregulation of tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002646
name: regulation of central tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002647
name: negative regulation of central tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "down regulation of central tolerance induction" EXACT []
synonym: "down-regulation of central tolerance induction" EXACT []
synonym: "downregulation of central tolerance induction" EXACT []
synonym: "inhibition of central tolerance induction" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
relationship: negatively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002648
name: positive regulation of central tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "activation of central tolerance induction" NARROW []
synonym: "stimulation of central tolerance induction" NARROW []
synonym: "up regulation of central tolerance induction" EXACT []
synonym: "up-regulation of central tolerance induction" EXACT []
synonym: "upregulation of central tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
relationship: positively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002649
name: regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002650
name: negative regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "down regulation of tolerance induction to self antigen" EXACT []
synonym: "down-regulation of tolerance induction to self antigen" EXACT []
synonym: "downregulation of tolerance induction to self antigen" EXACT []
synonym: "inhibition of tolerance induction to self antigen" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002651
name: positive regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "activation of tolerance induction to self antigen" NARROW []
synonym: "stimulation of tolerance induction to self antigen" NARROW []
synonym: "up regulation of tolerance induction to self antigen" EXACT []
synonym: "up-regulation of tolerance induction to self antigen" EXACT []
synonym: "upregulation of tolerance induction to self antigen" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002652
name: regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002653
name: negative regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "down regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "downregulation of tolerance induction dependent upon immune response" EXACT []
synonym: "inhibition of tolerance induction dependent upon immune response" NARROW []
synonym: "negative regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002654
name: positive regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "activation of tolerance induction dependent upon immune response" NARROW []
synonym: "positive regulation of immune response-dependent tolerance induction" EXACT []
synonym: "stimulation of tolerance induction dependent upon immune response" NARROW []
synonym: "up regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "upregulation of tolerance induction dependent upon immune response" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002655
name: regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
relationship: regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002656
name: negative regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "down regulation of tolerance induction to nonself antigen" EXACT []
synonym: "down-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "downregulation of tolerance induction to nonself antigen" EXACT []
synonym: "inhibition of tolerance induction to nonself antigen" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002657
name: positive regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "activation of tolerance induction to nonself antigen" NARROW []
synonym: "stimulation of tolerance induction to nonself antigen" NARROW []
synonym: "up regulation of tolerance induction to nonself antigen" EXACT []
synonym: "up-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "upregulation of tolerance induction to nonself antigen" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002658
name: regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
relationship: regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002659
name: negative regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "down regulation of peripheral tolerance induction" EXACT []
synonym: "down-regulation of peripheral tolerance induction" EXACT []
synonym: "downregulation of peripheral tolerance induction" EXACT []
synonym: "inhibition of peripheral tolerance induction" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002660
name: positive regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "activation of peripheral tolerance induction" NARROW []
synonym: "stimulation of peripheral tolerance induction" NARROW []
synonym: "up regulation of peripheral tolerance induction" EXACT []
synonym: "up-regulation of peripheral tolerance induction" EXACT []
synonym: "upregulation of peripheral tolerance induction" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
relationship: positively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002661
name: regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "regulation of B lymphocyte tolerance induction" EXACT []
synonym: "regulation of B-cell tolerance induction" EXACT []
synonym: "regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002662
name: negative regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "down regulation of B cell tolerance induction" EXACT []
synonym: "down-regulation of B cell tolerance induction" EXACT []
synonym: "downregulation of B cell tolerance induction" EXACT []
synonym: "inhibition of B cell tolerance induction" NARROW []
synonym: "negative regulation of B lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of B-cell tolerance induction" EXACT []
synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
relationship: negatively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002663
name: positive regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "activation of B cell tolerance induction" NARROW []
synonym: "positive regulation of B lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of B-cell tolerance induction" EXACT []
synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of B cell tolerance induction" NARROW []
synonym: "up regulation of B cell tolerance induction" EXACT []
synonym: "up-regulation of B cell tolerance induction" EXACT []
synonym: "upregulation of B cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
relationship: positively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002664
name: regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "regulation of T lymphocyte tolerance induction" EXACT []
synonym: "regulation of T-cell tolerance induction" EXACT []
synonym: "regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002665
name: negative regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "down regulation of T cell tolerance induction" EXACT []
synonym: "down-regulation of T cell tolerance induction" EXACT []
synonym: "downregulation of T cell tolerance induction" EXACT []
synonym: "inhibition of T cell tolerance induction" NARROW []
synonym: "negative regulation of T lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of T-cell tolerance induction" EXACT []
synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
relationship: negatively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002666
name: positive regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "activation of T cell tolerance induction" NARROW []
synonym: "positive regulation of T lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of T-cell tolerance induction" EXACT []
synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of T cell tolerance induction" NARROW []
synonym: "up regulation of T cell tolerance induction" EXACT []
synonym: "up-regulation of T cell tolerance induction" EXACT []
synonym: "upregulation of T cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
relationship: positively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002667
name: regulation of T cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "regulation of T lymphocyte anergy" EXACT []
synonym: "regulation of T-cell anergy" EXACT []
synonym: "regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002668
name: negative regulation of T cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "down regulation of T cell anergy" EXACT []
synonym: "down-regulation of T cell anergy" EXACT []
synonym: "downregulation of T cell anergy" EXACT []
synonym: "inhibition of T cell anergy" NARROW []
synonym: "negative regulation of T lymphocyte anergy" EXACT []
synonym: "negative regulation of T-cell anergy" EXACT []
synonym: "negative regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
relationship: negatively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002669
name: positive regulation of T cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "activation of T cell anergy" NARROW []
synonym: "positive regulation of T lymphocyte anergy" EXACT []
synonym: "positive regulation of T-cell anergy" EXACT []
synonym: "positive regulation of T-lymphocyte anergy" EXACT []
synonym: "stimulation of T cell anergy" NARROW []
synonym: "up regulation of T cell anergy" EXACT []
synonym: "up-regulation of T cell anergy" EXACT []
synonym: "upregulation of T cell anergy" EXACT []
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
relationship: positively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002670
name: regulation of B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "regulation of B lymphocyte anergy" EXACT []
synonym: "regulation of B-cell anergy" EXACT []
synonym: "regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002671
name: negative regulation of B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "down regulation of B cell anergy" EXACT []
synonym: "down-regulation of B cell anergy" EXACT []
synonym: "downregulation of B cell anergy" EXACT []
synonym: "inhibition of B cell anergy" NARROW []
synonym: "negative regulation of B lymphocyte anergy" EXACT []
synonym: "negative regulation of B-cell anergy" EXACT []
synonym: "negative regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
relationship: negatively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002672
name: positive regulation of B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "activation of B cell anergy" NARROW []
synonym: "positive regulation of B lymphocyte anergy" EXACT []
synonym: "positive regulation of B-cell anergy" EXACT []
synonym: "positive regulation of B-lymphocyte anergy" EXACT []
synonym: "stimulation of B cell anergy" NARROW []
synonym: "up regulation of B cell anergy" EXACT []
synonym: "up-regulation of B cell anergy" EXACT []
synonym: "upregulation of B cell anergy" EXACT []
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
relationship: positively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002673
name: regulation of acute inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
relationship: regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002674
name: negative regulation of acute inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "down regulation of acute inflammatory response" EXACT []
synonym: "down-regulation of acute inflammatory response" EXACT []
synonym: "downregulation of acute inflammatory response" EXACT []
synonym: "inhibition of acute inflammatory response" NARROW []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
relationship: negatively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002675
name: positive regulation of acute inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "activation of acute inflammatory response" NARROW []
synonym: "stimulation of acute inflammatory response" NARROW []
synonym: "up regulation of acute inflammatory response" EXACT []
synonym: "up-regulation of acute inflammatory response" EXACT []
synonym: "upregulation of acute inflammatory response" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
relationship: positively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002676
name: regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
relationship: regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002677
name: negative regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "down regulation of chronic inflammatory response" EXACT []
synonym: "down-regulation of chronic inflammatory response" EXACT []
synonym: "downregulation of chronic inflammatory response" EXACT []
synonym: "inhibition of chronic inflammatory response" NARROW []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
relationship: negatively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002678
name: positive regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "activation of chronic inflammatory response" NARROW []
synonym: "stimulation of chronic inflammatory response" NARROW []
synonym: "up regulation of chronic inflammatory response" EXACT []
synonym: "up-regulation of chronic inflammatory response" EXACT []
synonym: "upregulation of chronic inflammatory response" EXACT []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
relationship: positively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002679
name: respiratory burst involved in defense response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499]
is_a: GO:0002252 ! immune effector process
is_a: GO:0045730 ! respiratory burst
relationship: part_of GO:0006952 ! defense response

[Term]
id: GO:0002680
name: pro-T cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149]
synonym: "pro-T cell fate commitment" EXACT []
synonym: "pro-T lymphocyte fate commitment" EXACT []
synonym: "pro-T lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0002572 ! pro-T cell differentiation

[Term]
id: GO:0002681
name: somatic recombination of T cell receptor gene segments
namespace: biological_process
def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of TCR gene segments" EXACT []
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0002568 ! somatic diversification of T cell receptor genes

[Term]
id: GO:0002682
name: regulation of immune system process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0002376 ! immune system process

[Term]
id: GO:0002683
name: negative regulation of immune system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "down regulation of immune system process" EXACT []
synonym: "down-regulation of immune system process" EXACT []
synonym: "downregulation of immune system process" EXACT []
synonym: "inhibition of immune system process" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002684
name: positive regulation of immune system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "activation of immune system process" NARROW []
synonym: "stimulation of immune system process" NARROW []
synonym: "up regulation of immune system process" EXACT []
synonym: "up-regulation of immune system process" EXACT []
synonym: "upregulation of immune system process" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002685
name: regulation of leukocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "regulation of immune cell migration" EXACT []
synonym: "regulation of leucocyte migration" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002686
name: negative regulation of leukocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "down regulation of leukocyte migration" EXACT []
synonym: "down-regulation of leukocyte migration" EXACT []
synonym: "downregulation of leukocyte migration" EXACT []
synonym: "inhibition of leukocyte migration" NARROW []
synonym: "negative regulation of immune cell migration" EXACT []
synonym: "negative regulation of leucocyte migration" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "activation of leukocyte migration" NARROW []
synonym: "positive regulation of immune cell migration" EXACT []
synonym: "positive regulation of leucocyte migration" EXACT []
synonym: "stimulation of leukocyte migration" NARROW []
synonym: "up regulation of leukocyte migration" EXACT []
synonym: "up-regulation of leukocyte migration" EXACT []
synonym: "upregulation of leukocyte migration" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002688
name: regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "regulation of immune cell chemotaxis" EXACT []
synonym: "regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002689
name: negative regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "down regulation of leukocyte chemotaxis" EXACT []
synonym: "down-regulation of leukocyte chemotaxis" EXACT []
synonym: "downregulation of leukocyte chemotaxis" EXACT []
synonym: "inhibition of leukocyte chemotaxis" NARROW []
synonym: "negative regulation of immune cell chemotaxis" EXACT []
synonym: "negative regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050922 ! negative regulation of chemotaxis
relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002690
name: positive regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "activation of leukocyte chemotaxis" NARROW []
synonym: "positive regulation of immune cell chemotaxis" EXACT []
synonym: "positive regulation of leucocyte chemotaxis" EXACT []
synonym: "stimulation of leukocyte chemotaxis" NARROW []
synonym: "up regulation of leukocyte chemotaxis" EXACT []
synonym: "up-regulation of leukocyte chemotaxis" EXACT []
synonym: "upregulation of leukocyte chemotaxis" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050921 ! positive regulation of chemotaxis
relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002691
name: regulation of cellular extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add]
is_a: GO:0002685 ! regulation of leukocyte migration
relationship: regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002692
name: negative regulation of cellular extravasation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "down regulation of cellular extravasation" EXACT []
synonym: "down-regulation of cellular extravasation" EXACT []
synonym: "downregulation of cellular extravasation" EXACT []
synonym: "inhibition of cellular extravasation" NARROW []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
relationship: negatively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002693
name: positive regulation of cellular extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "activation of cellular extravasation" NARROW []
synonym: "stimulation of cellular extravasation" NARROW []
synonym: "up regulation of cellular extravasation" EXACT []
synonym: "up-regulation of cellular extravasation" EXACT []
synonym: "upregulation of cellular extravasation" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
relationship: positively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002694
name: regulation of leukocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "regulation of immune cell activation" EXACT []
synonym: "regulation of leucocyte activation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "down regulation of leukocyte activation" EXACT []
synonym: "down-regulation of leukocyte activation" EXACT []
synonym: "downregulation of leukocyte activation" EXACT []
synonym: "inhibition of leukocyte activation" NARROW []
synonym: "negative regulation of immune cell activation" EXACT []
synonym: "negative regulation of leucocyte activation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation
relationship: negatively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "activation of leukocyte activation" NARROW []
synonym: "positive regulation of immune cell activation" EXACT []
synonym: "positive regulation of leucocyte activation" EXACT []
synonym: "stimulation of leukocyte activation" NARROW []
synonym: "up regulation of leukocyte activation" EXACT []
synonym: "up-regulation of leukocyte activation" EXACT []
synonym: "upregulation of leukocyte activation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation
relationship: positively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002697
name: regulation of immune effector process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
relationship: regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002698
name: negative regulation of immune effector process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "down regulation of immune effector process" EXACT []
synonym: "down-regulation of immune effector process" EXACT []
synonym: "downregulation of immune effector process" EXACT []
synonym: "inhibition of immune effector process" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
relationship: negatively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002699
name: positive regulation of immune effector process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "activation of immune effector process" NARROW []
synonym: "stimulation of immune effector process" NARROW []
synonym: "up regulation of immune effector process" EXACT []
synonym: "up-regulation of immune effector process" EXACT []
synonym: "upregulation of immune effector process" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
relationship: positively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0010468 ! regulation of gene expression
relationship: regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "down regulation of production of molecular mediator of immune response" EXACT []
synonym: "down-regulation of production of molecular mediator of immune response" EXACT []
synonym: "downregulation of production of molecular mediator of immune response" EXACT []
synonym: "inhibition of production of molecular mediator of immune response" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010629 ! negative regulation of gene expression
relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "activation of production of molecular mediator of immune response" NARROW []
synonym: "stimulation of production of molecular mediator of immune response" NARROW []
synonym: "up regulation of production of molecular mediator of immune response" EXACT []
synonym: "up-regulation of production of molecular mediator of immune response" EXACT []
synonym: "upregulation of production of molecular mediator of immune response" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010628 ! positive regulation of gene expression
relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "regulation of immune cell mediated immunity" EXACT []
synonym: "regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
relationship: regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002704
name: negative regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of leukocyte mediated immunity" EXACT []
synonym: "down-regulation of leukocyte mediated immunity" EXACT []
synonym: "downregulation of leukocyte mediated immunity" EXACT []
synonym: "inhibition of leukocyte mediated immunity" NARROW []
synonym: "negative regulation of immune cell mediated immunity" EXACT []
synonym: "negative regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "activation of leukocyte mediated immunity" NARROW []
synonym: "positive regulation of immune cell mediated immunity" EXACT []
synonym: "positive regulation of leucocyte mediated immunity" EXACT []
synonym: "stimulation of leukocyte mediated immunity" NARROW []
synonym: "up regulation of leukocyte mediated immunity" EXACT []
synonym: "up-regulation of leukocyte mediated immunity" EXACT []
synonym: "upregulation of leukocyte mediated immunity" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "down regulation of lymphocyte mediated immunity" EXACT []
synonym: "down-regulation of lymphocyte mediated immunity" EXACT []
synonym: "downregulation of lymphocyte mediated immunity" EXACT []
synonym: "inhibition of lymphocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "activation of lymphocyte mediated immunity" NARROW []
synonym: "stimulation of lymphocyte mediated immunity" NARROW []
synonym: "up regulation of lymphocyte mediated immunity" EXACT []
synonym: "up-regulation of lymphocyte mediated immunity" EXACT []
synonym: "upregulation of lymphocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002709
name: regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "regulation of T lymphocyte mediated immunity" EXACT []
synonym: "regulation of T-cell mediated immunity" EXACT []
synonym: "regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002710
name: negative regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "down regulation of T cell mediated immunity" EXACT []
synonym: "down-regulation of T cell mediated immunity" EXACT []
synonym: "downregulation of T cell mediated immunity" EXACT []
synonym: "inhibition of T cell mediated immunity" NARROW []
synonym: "negative regulation of T lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of T-cell mediated immunity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002711
name: positive regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "activation of T cell mediated immunity" NARROW []
synonym: "positive regulation of T lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of T-cell mediated immunity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of T cell mediated immunity" NARROW []
synonym: "up regulation of T cell mediated immunity" EXACT []
synonym: "up-regulation of T cell mediated immunity" EXACT []
synonym: "upregulation of T cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002712
name: regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "regulation of B lymphocyte mediated immunity" EXACT []
synonym: "regulation of B-cell mediated immunity" EXACT []
synonym: "regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002713
name: negative regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "down regulation of B cell mediated immunity" EXACT []
synonym: "down-regulation of B cell mediated immunity" EXACT []
synonym: "downregulation of B cell mediated immunity" EXACT []
synonym: "inhibition of B cell mediated immunity" NARROW []
synonym: "negative regulation of B lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of B-cell mediated immunity" EXACT []
synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002714
name: positive regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "activation of B cell mediated immunity" NARROW []
synonym: "positive regulation of B lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of B-cell mediated immunity" EXACT []
synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of B cell mediated immunity" NARROW []
synonym: "up regulation of B cell mediated immunity" EXACT []
synonym: "up-regulation of B cell mediated immunity" EXACT []
synonym: "upregulation of B cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002715
name: regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045845
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "regulation of natural killer cell activity" RELATED []
synonym: "regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002716
name: negative regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0030102
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "down regulation of natural killer cell mediated immunity" EXACT []
synonym: "down-regulation of natural killer cell mediated immunity" EXACT []
synonym: "downregulation of natural killer cell mediated immunity" EXACT []
synonym: "inhibition of natural killer cell mediated immunity" NARROW []
synonym: "negative regulation of natural killer cell activity" RELATED []
synonym: "negative regulation of NK cell activity" RELATED []
synonym: "negative regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045824 ! negative regulation of innate immune response
relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002717
name: positive regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045846
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "activation of natural killer cell mediated immunity" NARROW []
synonym: "positive regulation of natural killer cell activity" RELATED []
synonym: "positive regulation of NK cell activity" RELATED []
synonym: "positive regulation of NK cell mediated immunity" EXACT []
synonym: "stimulation of natural killer cell mediated immunity" NARROW []
synonym: "up regulation of natural killer cell mediated immunity" EXACT []
synonym: "up-regulation of natural killer cell mediated immunity" EXACT []
synonym: "upregulation of natural killer cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045089 ! positive regulation of innate immune response
relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002718
name: regulation of cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002739
alt_id: GO:0002742
def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002719
name: negative regulation of cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002740
alt_id: GO:0002743
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" RELATED []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" RELATED []
synonym: "inhibition of cytokine production during immune response" RELATED []
synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "negative regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002720
name: positive regulation of cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002741
alt_id: GO:0002744
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "positive regulation of cytokine secretion involved in immune response" NARROW []
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" RELATED []
synonym: "up-regulation of cytokine production during immune response" RELATED []
synonym: "upregulation of cytokine production during immune response" RELATED []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002721
name: regulation of B cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "regulation of B lymphocyte cytokine production" EXACT []
synonym: "regulation of B-cell cytokine production" EXACT []
synonym: "regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002722
name: negative regulation of B cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "down regulation of B cell cytokine production" EXACT []
synonym: "down-regulation of B cell cytokine production" EXACT []
synonym: "downregulation of B cell cytokine production" EXACT []
synonym: "inhibition of B cell cytokine production" NARROW []
synonym: "negative regulation of B lymphocyte cytokine production" EXACT []
synonym: "negative regulation of B-cell cytokine production" EXACT []
synonym: "negative regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
relationship: negatively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002723
name: positive regulation of B cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "activation of B cell cytokine production" NARROW []
synonym: "positive regulation of B lymphocyte cytokine production" EXACT []
synonym: "positive regulation of B-cell cytokine production" EXACT []
synonym: "positive regulation of B-lymphocyte cytokine production" EXACT []
synonym: "stimulation of B cell cytokine production" NARROW []
synonym: "up regulation of B cell cytokine production" EXACT []
synonym: "up-regulation of B cell cytokine production" EXACT []
synonym: "upregulation of B cell cytokine production" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
relationship: positively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002724
name: regulation of T cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "regulation of T lymphocyte cytokine production" EXACT []
synonym: "regulation of T-cell cytokine production" EXACT []
synonym: "regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002725
name: negative regulation of T cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "down regulation of T cell cytokine production" EXACT []
synonym: "down-regulation of T cell cytokine production" EXACT []
synonym: "downregulation of T cell cytokine production" EXACT []
synonym: "inhibition of T cell cytokine production" NARROW []
synonym: "negative regulation of T lymphocyte cytokine production" EXACT []
synonym: "negative regulation of T-cell cytokine production" EXACT []
synonym: "negative regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
relationship: negatively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002726
name: positive regulation of T cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "activation of T cell cytokine production" NARROW []
synonym: "positive regulation of T lymphocyte cytokine production" EXACT []
synonym: "positive regulation of T-cell cytokine production" EXACT []
synonym: "positive regulation of T-lymphocyte cytokine production" EXACT []
synonym: "stimulation of T cell cytokine production" NARROW []
synonym: "up regulation of T cell cytokine production" EXACT []
synonym: "up-regulation of T cell cytokine production" EXACT []
synonym: "upregulation of T cell cytokine production" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
relationship: positively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002727
name: regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "regulation of NK cell cytokine production" EXACT []
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002728
name: negative regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "down regulation of natural killer cell cytokine production" EXACT []
synonym: "down-regulation of natural killer cell cytokine production" EXACT []
synonym: "downregulation of natural killer cell cytokine production" EXACT []
synonym: "inhibition of natural killer cell cytokine production" NARROW []
synonym: "negative regulation of NK cell cytokine production" EXACT []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002729
name: positive regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "activation of natural killer cell cytokine production" NARROW []
synonym: "positive regulation of NK cell cytokine production" EXACT []
synonym: "stimulation of natural killer cell cytokine production" NARROW []
synonym: "up regulation of natural killer cell cytokine production" EXACT []
synonym: "up-regulation of natural killer cell cytokine production" EXACT []
synonym: "upregulation of natural killer cell cytokine production" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002730
name: regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002731
name: negative regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of dendritic cell cytokine production" EXACT []
synonym: "down-regulation of dendritic cell cytokine production" EXACT []
synonym: "downregulation of dendritic cell cytokine production" EXACT []
synonym: "inhibition of dendritic cell cytokine production" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002732
name: positive regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "activation of dendritic cell cytokine production" NARROW []
synonym: "stimulation of dendritic cell cytokine production" NARROW []
synonym: "up regulation of dendritic cell cytokine production" EXACT []
synonym: "up-regulation of dendritic cell cytokine production" EXACT []
synonym: "upregulation of dendritic cell cytokine production" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002733
name: regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002734
name: negative regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002735
name: positive regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "activation of myeloid dendritic cell cytokine production" NARROW []
synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW []
synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002736
name: regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002737
name: negative regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002738
name: positive regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002745
name: antigen processing and presentation initiated by receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002746
name: antigen processing and presentation following pinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002747
name: antigen processing and presentation following phagocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002748
name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149]
synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT []
synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT []
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002749
name: obsolete antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen
namespace: biological_process
def: "OBSOLETE. Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0002750
name: antigen processing and presentation following macropinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257]
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002751
name: antigen processing and presentation following receptor mediated endocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002752
name: cell surface pattern recognition receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "cell surface PAMP receptor signaling pathway" EXACT []
synonym: "cell surface pathogen receptor signaling pathway" EXACT []
synonym: "cell surface pattern recognition receptor signalling pathway" EXACT []
synonym: "cell surface PRR signaling pathway" EXACT []
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002753
name: cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
alt_id: GO:0039528
def: "The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438]
comment: This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has been activated. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.
synonym: "cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway" NARROW [PMID:17328678]
synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT []
synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT []
synonym: "cytoplasmic PRR signaling pathway" EXACT []
synonym: "cytosolic PAMP receptor signaling pathway" EXACT []
synonym: "cytosolic pattern recognition receptor signaling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway
is_a: GO:0030522 ! intracellular receptor signaling pathway

[Term]
id: GO:0002754
name: endosomal pattern recognition receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a ligand to an intracellular vesicle pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "intracellular endosomal pattern recognition receptor signaling pathway" EXACT []
synonym: "intracellular vesicle PAMP receptor signaling pathway" RELATED []
synonym: "intracellular vesicle pathogen receptor signaling pathway" RELATED []
synonym: "intracellular vesicle pattern recognition receptor signaling pathway" RELATED []
synonym: "intracellular vesicle pattern recognition receptor signalling pathway" RELATED []
synonym: "intracellular vesicle PRR signaling pathway" RELATED []
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0002755
name: MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-dependent TLR signaling pathway" EXACT []
synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002756
name: MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "A toll-like receptor signaling pathway not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate an immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-independent TLR signaling pathway" EXACT []
synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002757
name: immune response-activating signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add]
synonym: "immune response-activating signal transduction" EXACT []
is_a: GO:0002253 ! activation of immune response
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002758
name: innate immune response-activating signaling pathway
namespace: biological_process
alt_id: GO:0009870
alt_id: GO:0010204
def: "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response." [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028]
synonym: "defence response signaling pathway, resistance gene-dependent" RELATED []
synonym: "defence response signaling pathway, resistance gene-independent" RELATED []
synonym: "defence response signalling pathway, resistance gene-dependent" RELATED []
synonym: "defence response signalling pathway, resistance gene-independent" RELATED []
synonym: "defense response signaling pathway, resistance gene-dependent" RELATED []
synonym: "defense response signaling pathway, resistance gene-independent" RELATED []
synonym: "defense response signalling pathway, resistance gene-dependent" RELATED []
synonym: "effector triggered immunity" BROAD []
synonym: "effector-triggered immune signaling" RELATED []
synonym: "effector-triggered immunity" BROAD []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002757 ! immune response-activating signaling pathway

[Term]
id: GO:0002759
name: regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002760
name: positive regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
synonym: "activation of antimicrobial humoral response" NARROW []
synonym: "stimulation of antimicrobial humoral response" NARROW []
synonym: "up regulation of antimicrobial humoral response" EXACT []
synonym: "up-regulation of antimicrobial humoral response" EXACT []
synonym: "upregulation of antimicrobial humoral response" EXACT []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
relationship: positively_regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002761
name: regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
relationship: regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "down regulation of myeloid leukocyte differentiation" EXACT []
synonym: "down-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "downregulation of myeloid leukocyte differentiation" EXACT []
synonym: "inhibition of myeloid leukocyte differentiation" NARROW []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "activation of myeloid leukocyte differentiation" NARROW []
synonym: "stimulation of myeloid leukocyte differentiation" NARROW []
synonym: "up regulation of myeloid leukocyte differentiation" EXACT []
synonym: "up-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "upregulation of myeloid leukocyte differentiation" EXACT []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002764
name: immune response-regulating signaling pathway
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0002765
name: immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149]
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002766
name: innate immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
is_a: GO:0002765 ! immune response-inhibiting signal transduction

[Term]
id: GO:0002767
name: immune response-inhibiting cell surface receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT []
is_a: GO:0002765 ! immune response-inhibiting signal transduction
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002768
name: immune response-regulating cell surface receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002764 ! immune response-regulating signaling pathway
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0002769
name: natural killer cell inhibitory signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory KIR signaling pathway" NARROW []
synonym: "killer cell inhibitory receptor signaling pathway" NARROW []
synonym: "Ly49 inhibitory receptor signaling pathway" RELATED []
synonym: "natural killer cell inhibitory signalling pathway" EXACT []
synonym: "NK cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002770
name: T cell inhibitory signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309]
synonym: "T cell inhibitory signalling pathway" EXACT []
synonym: "T lymphocyte inhibitory signaling pathway" EXACT []
synonym: "T-cell inhibitory signaling pathway" EXACT []
synonym: "T-lymphocyte inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002771
name: inhibitory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "killer cell inhibitory receptor signaling pathway" EXACT []
synonym: "KIR signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002772
name: inhibitory C-type lectin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT []
synonym: "Ly49 inhibitory receptor signaling pathway" RELATED []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002773
name: B cell inhibitory signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920]
synonym: "B cell inhibitory signalling pathway" EXACT []
synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT []
synonym: "B-cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002774
name: Fc receptor mediated inhibitory signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149]
synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT []
synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002775
name: antimicrobial peptide production
namespace: biological_process
def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: part_of GO:0061844 ! antimicrobial humoral immune response mediated by antimicrobial peptide

[Term]
id: GO:0002776
name: antimicrobial peptide secretion
namespace: biological_process
def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002790 ! peptide secretion
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002777
name: antimicrobial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0043043 ! peptide biosynthetic process
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002778
name: antibacterial peptide production
namespace: biological_process
def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019731 ! antibacterial humoral response

[Term]
id: GO:0002779
name: antibacterial peptide secretion
namespace: biological_process
def: "The regulated release of an antibacterial peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002780
name: antibacterial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002781
name: antifungal peptide production
namespace: biological_process
def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019732 ! antifungal humoral response

[Term]
id: GO:0002782
name: antifungal peptide secretion
namespace: biological_process
def: "The regulated release of an antifungal peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002783
name: antifungal peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002784
name: regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0002759 ! regulation of antimicrobial humoral response
relationship: regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002785
name: negative regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
synonym: "down regulation of antimicrobial peptide production" EXACT []
synonym: "down-regulation of antimicrobial peptide production" EXACT []
synonym: "downregulation of antimicrobial peptide production" EXACT []
synonym: "inhibition of antimicrobial peptide production" NARROW []
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0008348 ! negative regulation of antimicrobial humoral response
relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002786
name: regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
relationship: regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002787
name: negative regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "down regulation of antibacterial peptide production" EXACT []
synonym: "down-regulation of antibacterial peptide production" EXACT []
synonym: "downregulation of antibacterial peptide production" EXACT []
synonym: "inhibition of antibacterial peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:1900425 ! negative regulation of defense response to bacterium
relationship: negatively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002788
name: regulation of antifungal peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:1900150 ! regulation of defense response to fungus
relationship: regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002789
name: negative regulation of antifungal peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "down regulation of antifungal peptide production" EXACT []
synonym: "down-regulation of antifungal peptide production" EXACT []
synonym: "downregulation of antifungal peptide production" EXACT []
synonym: "inhibition of antifungal peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
relationship: negatively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002790
name: peptide secretion
namespace: biological_process
def: "The controlled release of a peptide from a cell or a tissue." [GOC:add]
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0002791
name: regulation of peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090087 ! regulation of peptide transport
relationship: regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002792
name: negative regulation of peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "down regulation of peptide secretion" EXACT []
synonym: "down-regulation of peptide secretion" EXACT []
synonym: "downregulation of peptide secretion" EXACT []
synonym: "inhibition of peptide secretion" NARROW []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051048 ! negative regulation of secretion
relationship: negatively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002793
name: positive regulation of peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "activation of peptide secretion" NARROW []
synonym: "stimulation of peptide secretion" NARROW []
synonym: "up regulation of peptide secretion" EXACT []
synonym: "up-regulation of peptide secretion" EXACT []
synonym: "upregulation of peptide secretion" EXACT []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051047 ! positive regulation of secretion
relationship: positively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002794
name: regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0002791 ! regulation of peptide secretion
relationship: regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002795
name: negative regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "down regulation of antimicrobial peptide secretion" EXACT []
synonym: "down-regulation of antimicrobial peptide secretion" EXACT []
synonym: "downregulation of antimicrobial peptide secretion" EXACT []
synonym: "inhibition of antimicrobial peptide secretion" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002796
name: positive regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "activation of antimicrobial peptide secretion" NARROW []
synonym: "stimulation of antimicrobial peptide secretion" NARROW []
synonym: "up regulation of antimicrobial peptide secretion" EXACT []
synonym: "up-regulation of antimicrobial peptide secretion" EXACT []
synonym: "upregulation of antimicrobial peptide secretion" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002797
name: regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002798
name: negative regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "down regulation of antibacterial peptide secretion" EXACT []
synonym: "down-regulation of antibacterial peptide secretion" EXACT []
synonym: "downregulation of antibacterial peptide secretion" EXACT []
synonym: "inhibition of antibacterial peptide secretion" NARROW []
is_a: GO:0002787 ! negative regulation of antibacterial peptide production
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002799
name: positive regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "activation of antibacterial peptide secretion" NARROW []
synonym: "stimulation of antibacterial peptide secretion" NARROW []
synonym: "up regulation of antibacterial peptide secretion" EXACT []
synonym: "up-regulation of antibacterial peptide secretion" EXACT []
synonym: "upregulation of antibacterial peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
is_a: GO:0002803 ! positive regulation of antibacterial peptide production
relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002800
name: regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002801
name: negative regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "down regulation of antifungal peptide secretion" EXACT []
synonym: "down-regulation of antifungal peptide secretion" EXACT []
synonym: "downregulation of antifungal peptide secretion" EXACT []
synonym: "inhibition of antifungal peptide secretion" NARROW []
is_a: GO:0002789 ! negative regulation of antifungal peptide production
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002802
name: positive regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "activation of antifungal peptide secretion" NARROW []
synonym: "stimulation of antifungal peptide secretion" NARROW []
synonym: "up regulation of antifungal peptide secretion" EXACT []
synonym: "up-regulation of antifungal peptide secretion" EXACT []
synonym: "upregulation of antifungal peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
is_a: GO:0002804 ! positive regulation of antifungal peptide production
relationship: positively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002803
name: positive regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "activation of antibacterial peptide production" NARROW []
synonym: "stimulation of antibacterial peptide production" NARROW []
synonym: "up regulation of antibacterial peptide production" EXACT []
synonym: "up-regulation of antibacterial peptide production" EXACT []
synonym: "upregulation of antibacterial peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:1900426 ! positive regulation of defense response to bacterium
relationship: positively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002804
name: positive regulation of antifungal peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "activation of antifungal peptide production" NARROW []
synonym: "stimulation of antifungal peptide production" NARROW []
synonym: "up regulation of antifungal peptide production" EXACT []
synonym: "up-regulation of antifungal peptide production" EXACT []
synonym: "upregulation of antifungal peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
relationship: positively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002805
name: regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002806
name: negative regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002807
name: positive regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "activation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002808
name: regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002809
name: negative regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW []
is_a: GO:0002787 ! negative regulation of antibacterial peptide production
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002810
name: regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002811
name: negative regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
synonym: "down regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "downregulation of antifungal peptide biosynthetic process" EXACT []
synonym: "inhibition of antifungal peptide biosynthetic process" NARROW []
is_a: GO:0002789 ! negative regulation of antifungal peptide production
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process
relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002812
name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium

[Term]
id: GO:0002813
name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002814
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002815
name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium

[Term]
id: GO:0002816
name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002817
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002819
name: regulation of adaptive immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002820
name: negative regulation of adaptive immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "down regulation of adaptive immune response" EXACT []
synonym: "down-regulation of adaptive immune response" EXACT []
synonym: "downregulation of adaptive immune response" EXACT []
synonym: "inhibition of adaptive immune response" NARROW []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "activation of adaptive immune response" NARROW []
synonym: "stimulation of adaptive immune response" NARROW []
synonym: "up regulation of adaptive immune response" EXACT []
synonym: "up-regulation of adaptive immune response" EXACT []
synonym: "upregulation of adaptive immune response" EXACT []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002819 ! regulation of adaptive immune response
relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002823
name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002825
name: regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002826
name: negative regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "down regulation of T-helper 1 type immune response" EXACT []
synonym: "down-regulation of T-helper 1 type immune response" EXACT []
synonym: "downregulation of T-helper 1 type immune response" EXACT []
synonym: "inhibition of T-helper 1 type immune response" NARROW []
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002827
name: positive regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "activation of T-helper 1 type immune response" NARROW []
synonym: "stimulation of T-helper 1 type immune response" NARROW []
synonym: "up regulation of T-helper 1 type immune response" EXACT []
synonym: "up-regulation of T-helper 1 type immune response" EXACT []
synonym: "upregulation of T-helper 1 type immune response" EXACT []
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002828
name: regulation of type 2 immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002829
name: negative regulation of type 2 immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "down regulation of type 2 immune response" EXACT []
synonym: "down-regulation of type 2 immune response" EXACT []
synonym: "downregulation of type 2 immune response" EXACT []
synonym: "inhibition of type 2 immune response" NARROW []
synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "negative regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002830
name: positive regulation of type 2 immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "activation of type 2 immune response" NARROW []
synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "positive regulation of Th2 immune response" NARROW [GOC:add]
synonym: "stimulation of type 2 immune response" NARROW []
synonym: "up regulation of type 2 immune response" EXACT []
synonym: "up-regulation of type 2 immune response" EXACT []
synonym: "upregulation of type 2 immune response" EXACT []
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002834
name: regulation of response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "regulation of response to tumour cell" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
relationship: regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002835
name: negative regulation of response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "down regulation of response to tumor cell" EXACT []
synonym: "down-regulation of response to tumor cell" EXACT []
synonym: "downregulation of response to tumor cell" EXACT []
synonym: "inhibition of response to tumor cell" NARROW []
synonym: "negative regulation of response to tumour cell" EXACT []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
relationship: negatively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002836
name: positive regulation of response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "activation of response to tumor cell" NARROW []
synonym: "positive regulation of response to tumour cell" EXACT []
synonym: "stimulation of response to tumor cell" NARROW []
synonym: "up regulation of response to tumor cell" EXACT []
synonym: "up-regulation of response to tumor cell" EXACT []
synonym: "upregulation of response to tumor cell" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
relationship: positively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002837
name: regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "regulation of immune response to tumour cell" EXACT []
is_a: GO:0002834 ! regulation of response to tumor cell
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002838
name: negative regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "down regulation of immune response to tumor cell" EXACT []
synonym: "down-regulation of immune response to tumor cell" EXACT []
synonym: "downregulation of immune response to tumor cell" EXACT []
synonym: "inhibition of immune response to tumor cell" NARROW []
synonym: "negative regulation of immune response to tumour cell" EXACT []
is_a: GO:0002835 ! negative regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002839
name: positive regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "activation of immune response to tumor cell" NARROW []
synonym: "positive regulation of immune response to tumour cell" EXACT []
synonym: "stimulation of immune response to tumor cell" NARROW []
synonym: "up regulation of immune response to tumor cell" EXACT []
synonym: "up-regulation of immune response to tumor cell" EXACT []
synonym: "upregulation of immune response to tumor cell" EXACT []
is_a: GO:0002836 ! positive regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002840
name: regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002841
name: negative regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW []
synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002842
name: positive regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "activation of T cell mediated immune response to tumor cell" NARROW []
synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002843
name: regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002837 ! regulation of immune response to tumor cell
relationship: regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002844
name: negative regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of tolerance induction to tumor cell" EXACT []
synonym: "downregulation of tolerance induction to tumor cell" EXACT []
synonym: "inhibition of tolerance induction to tumor cell" NARROW []
synonym: "negative regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002845
name: positive regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "activation of tolerance induction to tumor cell" NARROW []
synonym: "positive regulation of tolerance induction to tumour cell" EXACT []
synonym: "stimulation of tolerance induction to tumor cell" NARROW []
synonym: "up regulation of tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of tolerance induction to tumor cell" EXACT []
synonym: "upregulation of tolerance induction to tumor cell" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002846
name: regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002847
name: negative regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW []
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction
relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002848
name: positive regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "activation of T cell tolerance induction to tumor cell" NARROW []
synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW []
synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT []
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction
relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002849
name: regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002709 ! regulation of T cell mediated immunity
relationship: regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002850
name: negative regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "down regulation of peripheral T cell tolerance induction" EXACT []
synonym: "down-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "downregulation of peripheral T cell tolerance induction" EXACT []
synonym: "inhibition of peripheral T cell tolerance induction" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002851
name: positive regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "activation of peripheral T cell tolerance induction" NARROW []
synonym: "stimulation of peripheral T cell tolerance induction" NARROW []
synonym: "up regulation of peripheral T cell tolerance induction" EXACT []
synonym: "up-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "upregulation of peripheral T cell tolerance induction" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002852
name: regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002853
name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002854
name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002855
name: regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002856
name: negative regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002857
name: positive regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002858
name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002859
name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity
relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002860
name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002861
name: regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002862
name: negative regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002863
name: positive regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002864
name: regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002865
name: negative regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002866
name: positive regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002867
name: regulation of B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "regulation of B lymphocyte deletion" EXACT []
synonym: "regulation of B-cell deletion" EXACT []
synonym: "regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
relationship: regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002868
name: negative regulation of B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "down regulation of B cell deletion" EXACT []
synonym: "down-regulation of B cell deletion" EXACT []
synonym: "downregulation of B cell deletion" EXACT []
synonym: "inhibition of B cell deletion" NARROW []
synonym: "negative regulation of B lymphocyte deletion" EXACT []
synonym: "negative regulation of B-cell deletion" EXACT []
synonym: "negative regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002903 ! negative regulation of B cell apoptotic process
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
relationship: negatively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002869
name: positive regulation of B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "activation of B cell deletion" NARROW []
synonym: "positive regulation of B lymphocyte deletion" EXACT []
synonym: "positive regulation of B-cell deletion" EXACT []
synonym: "positive regulation of B-lymphocyte deletion" EXACT []
synonym: "stimulation of B cell deletion" NARROW []
synonym: "up regulation of B cell deletion" EXACT []
synonym: "up-regulation of B cell deletion" EXACT []
synonym: "upregulation of B cell deletion" EXACT []
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002904 ! positive regulation of B cell apoptotic process
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
relationship: positively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002870
name: T cell anergy
namespace: biological_process
def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte anergy" EXACT []
synonym: "T-cell anergy" EXACT []
synonym: "T-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002871
name: regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002872
name: negative regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "down regulation of natural killer cell tolerance induction" EXACT []
synonym: "down-regulation of natural killer cell tolerance induction" EXACT []
synonym: "downregulation of natural killer cell tolerance induction" EXACT []
synonym: "inhibition of natural killer cell tolerance induction" NARROW []
synonym: "negative regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002873
name: positive regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "activation of natural killer cell tolerance induction" NARROW []
synonym: "positive regulation of NK cell tolerance induction" EXACT []
synonym: "stimulation of natural killer cell tolerance induction" NARROW []
synonym: "up regulation of natural killer cell tolerance induction" EXACT []
synonym: "up-regulation of natural killer cell tolerance induction" EXACT []
synonym: "upregulation of natural killer cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002874
name: regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002875
name: negative regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002876
name: positive regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002877
name: regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002878
name: negative regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002879
name: positive regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002880
name: regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002881
name: negative regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002882
name: positive regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002883
name: regulation of hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add]
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
relationship: regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002884
name: negative regulation of hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "down regulation of hypersensitivity" EXACT []
synonym: "down-regulation of hypersensitivity" EXACT []
synonym: "downregulation of hypersensitivity" EXACT []
synonym: "inhibition of hypersensitivity" NARROW []
is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
relationship: negatively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002885
name: positive regulation of hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "activation of hypersensitivity" NARROW []
synonym: "stimulation of hypersensitivity" NARROW []
synonym: "up regulation of hypersensitivity" EXACT []
synonym: "up-regulation of hypersensitivity" EXACT []
synonym: "upregulation of hypersensitivity" EXACT []
is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
relationship: positively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "activation of myeloid leukocyte mediated immunity" NARROW []
synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW []
synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002889
name: regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
is_a: GO:0002712 ! regulation of B cell mediated immunity
relationship: regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002890
name: negative regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "down regulation of immunoglobulin mediated immune response" EXACT []
synonym: "down-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "downregulation of immunoglobulin mediated immune response" EXACT []
synonym: "inhibition of immunoglobulin mediated immune response" NARROW []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002891
name: positive regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "activation of immunoglobulin mediated immune response" NARROW []
synonym: "stimulation of immunoglobulin mediated immune response" NARROW []
synonym: "up regulation of immunoglobulin mediated immune response" EXACT []
synonym: "up-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "upregulation of immunoglobulin mediated immune response" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002892
name: regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002893
name: negative regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "down regulation of type II hypersensitivity" EXACT []
synonym: "down-regulation of type II hypersensitivity" EXACT []
synonym: "downregulation of type II hypersensitivity" EXACT []
synonym: "inhibition of type II hypersensitivity" NARROW []
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: negatively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002894
name: positive regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "activation of type II hypersensitivity" NARROW []
synonym: "stimulation of type II hypersensitivity" NARROW []
synonym: "up regulation of type II hypersensitivity" EXACT []
synonym: "up-regulation of type II hypersensitivity" EXACT []
synonym: "upregulation of type II hypersensitivity" EXACT []
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: positively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002895
name: regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
is_a: GO:0002646 ! regulation of central tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
relationship: regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002896
name: negative regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "down regulation of central B cell tolerance induction" EXACT []
synonym: "down-regulation of central B cell tolerance induction" EXACT []
synonym: "downregulation of central B cell tolerance induction" EXACT []
synonym: "inhibition of central B cell tolerance induction" NARROW []
is_a: GO:0002647 ! negative regulation of central tolerance induction
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002897
name: positive regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "activation of central B cell tolerance induction" NARROW []
synonym: "stimulation of central B cell tolerance induction" NARROW []
synonym: "up regulation of central B cell tolerance induction" EXACT []
synonym: "up-regulation of central B cell tolerance induction" EXACT []
synonym: "upregulation of central B cell tolerance induction" EXACT []
is_a: GO:0002648 ! positive regulation of central tolerance induction
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
relationship: positively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002898
name: regulation of central B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add]
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
relationship: regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002899
name: negative regulation of central B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "down regulation of central B cell deletion" EXACT []
synonym: "down-regulation of central B cell deletion" EXACT []
synonym: "downregulation of central B cell deletion" EXACT []
synonym: "inhibition of central B cell deletion" NARROW []
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002896 ! negative regulation of central B cell tolerance induction
is_a: GO:0002898 ! regulation of central B cell deletion
is_a: GO:0045578 ! negative regulation of B cell differentiation
relationship: negatively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002900
name: positive regulation of central B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "activation of central B cell deletion" NARROW []
synonym: "stimulation of central B cell deletion" NARROW []
synonym: "up regulation of central B cell deletion" EXACT []
synonym: "up-regulation of central B cell deletion" EXACT []
synonym: "upregulation of central B cell deletion" EXACT []
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002897 ! positive regulation of central B cell tolerance induction
is_a: GO:0002898 ! regulation of central B cell deletion
is_a: GO:0045579 ! positive regulation of B cell differentiation
relationship: positively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002901
name: mature B cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of mature B cells" EXACT []
synonym: "apoptosis of mature B lymphocytes" EXACT []
synonym: "apoptosis of mature B-cells" EXACT []
synonym: "apoptosis of mature B-lymphocytes" EXACT []
synonym: "mature B cell apoptosis" NARROW []
synonym: "mature B cell programmed cell death by apoptosis" EXACT []
synonym: "mature B lymphocyte apoptosis" EXACT []
synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "mature B-cell apoptosis" EXACT []
synonym: "mature B-cell programmed cell death by apoptosis" EXACT []
synonym: "mature B-lymphocyte apoptosis" EXACT []
synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of mature B cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of mature B-cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, mature B cells" EXACT []
synonym: "programmed cell death, mature B lymphocytes" EXACT []
synonym: "programmed cell death, mature B-cells" EXACT []
synonym: "programmed cell death, mature B-lymphocytes" EXACT []
is_a: GO:0001783 ! B cell apoptotic process
relationship: part_of GO:0001782 ! B cell homeostasis

[Term]
id: GO:0002902
name: regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of B cell apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
relationship: regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002903
name: negative regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of B cell apoptosis" EXACT []
synonym: "down-regulation of B cell apoptosis" EXACT []
synonym: "downregulation of B cell apoptosis" EXACT []
synonym: "inhibition of B cell apoptosis" NARROW []
synonym: "negative regulation of B cell apoptosis" NARROW []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
relationship: negatively_regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002904
name: positive regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of B cell apoptosis" NARROW []
synonym: "positive regulation of B cell apoptosis" NARROW []
synonym: "stimulation of B cell apoptosis" NARROW []
synonym: "up regulation of B cell apoptosis" EXACT []
synonym: "up-regulation of B cell apoptosis" EXACT []
synonym: "upregulation of B cell apoptosis" EXACT []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
relationship: positively_regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002905
name: regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0002902 ! regulation of B cell apoptotic process
relationship: regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002906
name: negative regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of mature B cell apoptosis" EXACT []
synonym: "down-regulation of mature B cell apoptosis" EXACT []
synonym: "downregulation of mature B cell apoptosis" EXACT []
synonym: "inhibition of mature B cell apoptosis" NARROW []
synonym: "negative regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002903 ! negative regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
relationship: negatively_regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002907
name: positive regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of mature B cell apoptosis" NARROW []
synonym: "positive regulation of mature B cell apoptosis" NARROW []
synonym: "stimulation of mature B cell apoptosis" NARROW []
synonym: "up regulation of mature B cell apoptosis" EXACT []
synonym: "up-regulation of mature B cell apoptosis" EXACT []
synonym: "upregulation of mature B cell apoptosis" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002904 ! positive regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
relationship: positively_regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002908
name: regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002867 ! regulation of B cell deletion
relationship: regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002909
name: negative regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "down regulation of peripheral B cell deletion" EXACT []
synonym: "down-regulation of peripheral B cell deletion" EXACT []
synonym: "downregulation of peripheral B cell deletion" EXACT []
synonym: "inhibition of peripheral B cell deletion" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002910
name: positive regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "activation of peripheral B cell deletion" NARROW []
synonym: "stimulation of peripheral B cell deletion" NARROW []
synonym: "up regulation of peripheral B cell deletion" EXACT []
synonym: "up-regulation of peripheral B cell deletion" EXACT []
synonym: "upregulation of peripheral B cell deletion" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
relationship: positively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002911
name: regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002912
name: negative regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "down regulation of lymphocyte anergy" EXACT []
synonym: "down-regulation of lymphocyte anergy" EXACT []
synonym: "downregulation of lymphocyte anergy" EXACT []
synonym: "inhibition of lymphocyte anergy" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: negatively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002913
name: positive regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "activation of lymphocyte anergy" NARROW []
synonym: "stimulation of lymphocyte anergy" NARROW []
synonym: "up regulation of lymphocyte anergy" EXACT []
synonym: "up-regulation of lymphocyte anergy" EXACT []
synonym: "upregulation of lymphocyte anergy" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: positively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002914
name: regulation of central B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add]
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
relationship: regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002915
name: negative regulation of central B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "down regulation of central B cell anergy" EXACT []
synonym: "down-regulation of central B cell anergy" EXACT []
synonym: "downregulation of central B cell anergy" EXACT []
synonym: "inhibition of central B cell anergy" NARROW []
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002896 ! negative regulation of central B cell tolerance induction
is_a: GO:0002914 ! regulation of central B cell anergy
is_a: GO:0045578 ! negative regulation of B cell differentiation
relationship: negatively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002916
name: positive regulation of central B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "activation of central B cell anergy" NARROW []
synonym: "stimulation of central B cell anergy" NARROW []
synonym: "up regulation of central B cell anergy" EXACT []
synonym: "up-regulation of central B cell anergy" EXACT []
synonym: "upregulation of central B cell anergy" EXACT []
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002897 ! positive regulation of central B cell tolerance induction
is_a: GO:0002914 ! regulation of central B cell anergy
is_a: GO:0045579 ! positive regulation of B cell differentiation
relationship: positively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002917
name: regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002712 ! regulation of B cell mediated immunity
relationship: regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002918
name: negative regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "down regulation of peripheral B cell anergy" EXACT []
synonym: "down-regulation of peripheral B cell anergy" EXACT []
synonym: "downregulation of peripheral B cell anergy" EXACT []
synonym: "inhibition of peripheral B cell anergy" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002917 ! regulation of peripheral B cell anergy
relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002919
name: positive regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "activation of peripheral B cell anergy" NARROW []
synonym: "stimulation of peripheral B cell anergy" NARROW []
synonym: "up regulation of peripheral B cell anergy" EXACT []
synonym: "up-regulation of peripheral B cell anergy" EXACT []
synonym: "upregulation of peripheral B cell anergy" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002917 ! regulation of peripheral B cell anergy
relationship: positively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002920
name: regulation of humoral immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002921
name: negative regulation of humoral immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "down regulation of humoral immune response" EXACT []
synonym: "down-regulation of humoral immune response" EXACT []
synonym: "downregulation of humoral immune response" EXACT []
synonym: "inhibition of humoral immune response" NARROW []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002922
name: positive regulation of humoral immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "activation of humoral immune response" NARROW []
synonym: "stimulation of humoral immune response" NARROW []
synonym: "up regulation of humoral immune response" EXACT []
synonym: "up-regulation of humoral immune response" EXACT []
synonym: "upregulation of humoral immune response" EXACT []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002923
name: regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0002920 ! regulation of humoral immune response
relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002924
name: negative regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW []
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002925
name: positive regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002926
name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
namespace: biological_process
def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, PMID:22768388]
synonym: "mcm5 modification" EXACT []
synonym: "mcm5s2U34 biosynthesis" EXACT []
synonym: "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis" EXACT []
is_a: GO:0002098 ! tRNA wobble uridine modification

[Term]
id: GO:0002927
name: archaeosine-tRNA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs." [GOC:hjd, PMID:20129918]
comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine.
is_a: GO:0006400 ! tRNA modification
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0002929
name: MECO complex
namespace: cellular_component
def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642]
synonym: "meta-coactivator complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0002930
name: trabecular meshwork development
namespace: biological_process
def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002931
name: response to ischemia
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd]
comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia.
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0002932
name: tendon sheath development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0035989 ! tendon development

[Term]
id: GO:0002933
name: lipid hydroxylation
namespace: biological_process
def: "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937]
synonym: "fatty acid hydroxylation" RELATED []
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0002934
name: desmosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd]
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0002935
name: tRNA (adenine(37)-C2)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine37 in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine37 in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine." [PMID:22891362, RHEA:43332]
synonym: "tRNA (adenine(37)-C(2))-methyltransferase activity" EXACT []
synonym: "tRNA (adenosine(37)-C2-)-methyltransferase activity" EXACT []
xref: MetaCyc:RXN0-7007
xref: RHEA:43332
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0002936
name: bradykinin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291]
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0002937
name: tRNA 4-thiouridine biosynthesis
namespace: biological_process
def: "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs." [ISBN:155581073X]
comment: In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to an unidentified intermediate. NuvC also participates in thiamine synthesis.
is_a: GO:0034227 ! tRNA thio-modification

[Term]
id: GO:0002938
name: tRNA guanine ribose methylation
namespace: biological_process
def: "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety." [ISBN:1555811337]
is_a: GO:0002128 ! tRNA nucleoside ribose methylation

[Term]
id: GO:0002939
name: tRNA N1-guanine methylation
namespace: biological_process
def: "The process whereby a guanine in tRNA is methylated at position N1 of the guanine." [ISBN:155581073X, ISBN:1555811337]
synonym: "tRNA m1-guanine biosynthesis" RELATED []
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002940
name: tRNA N2-guanine methylation
namespace: biological_process
def: "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337]
synonym: "tRNA m2-guanine biosynthesis" RELATED []
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002941
name: synoviocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues." [PMID:10770586, PMID:9546370]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0002942
name: tRNA m2,2-guanine biosynthesis
namespace: biological_process
def: "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002943
name: tRNA dihydrouridine synthesis
namespace: biological_process
def: "The process whereby a uridine in a transfer RNA is converted to dihydrouridine." [GOC:hjd, ISBN:155581073X]
comment: Dihydrouridine is found in numerous positions within loop I, the so-called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b.
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0002944
name: cyclin K-CDK12 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]
synonym: "CycK/Cdk12 complex" RELATED []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0002945
name: cyclin K-CDK13 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]
synonym: "CycK/Cdk13 complex" RELATED []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0002946
name: tRNA C5-cytosine methylation
namespace: biological_process
def: "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:155581073X]
synonym: "tRNA 5-methylcytosine biosynthesis" RELATED []
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002947
name: tumor necrosis factor receptor superfamily complex
namespace: cellular_component
def: "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily." [GOC:krc]
synonym: "TNF receptor superfamily complex" RELATED []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0002948
name: archaeosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA." [PMID:20129918, RHEA:54084]
synonym: "ArcS" RELATED []
synonym: "glutamine:preQ0-tRNA amidinotransferase" RELATED []
xref: EC:2.6.1.97
xref: RHEA:54084
xref: Wikipedia:Archaeosine_synthase
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0002949
name: tRNA threonylcarbamoyladenosine modification
namespace: biological_process
alt_id: GO:0070526
def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]
synonym: "t6A biosynthesis" EXACT [PMID:19287007]
synonym: "t6A biosynthetic process" EXACT [PMID:19287007]
synonym: "t6A tRNA modification" EXACT []
synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine biosynthetic process" EXACT []
synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah]
is_a: GO:0006400 ! tRNA modification
is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process

[Term]
id: GO:0002950
name: ceramide phosphoethanolamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H+." [EC:2.7.8.48, PMID:25667419]
xref: EC:2.7.8.48
xref: Reactome:R-HSA-8959462 "SAMD8 transfers phosphatidyl from PE onto C16DH CER"
xref: RHEA:45896
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0002951
name: leukotriene-C(4) hydrolase
namespace: molecular_function
def: "Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate." [PMID:9774450, RHEA:31563]
comment: The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC:3.4.19.13). PMID:9774450 cites that the mouse form of this enzyme failed to measure activity towards glutathione.
xref: EC:3.4.19.14
xref: RHEA:31563
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0002952
name: (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate." [RHEA:44360]
synonym: "phospho-AI-2 isomerase activity" RELATED []
xref: EC:5.3.1.32
xref: MetaCyc:RXN-15216
xref: RHEA:44360
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0002953
name: 5'-deoxynucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate." [RHEA:36167]
xref: EC:3.1.3.89
xref: RHEA:36167
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0003001
name: obsolete generation of a signal involved in cell-cell signaling
namespace: biological_process
def: "OBSOLETE. The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph]
comment: This term was made obsolete because biosynthesis of a signal occurs before the start of cell-cell signaling.
synonym: "formation of a signal" BROAD []
synonym: "generation of a signal involved in cell-cell signaling" EXACT []
synonym: "generation of a signal involved in cell-cell signalling" EXACT []
synonym: "signal generation" BROAD []
is_obsolete: true
consider: GO:0007267
consider: GO:0010496
consider: GO:0023061

[Term]
id: GO:0003002
name: regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0003003
name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage
namespace: biological_process
def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0003004
name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage
namespace: biological_process
def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
relationship: part_of GO:0048164 ! distinct antral spaces stage

[Term]
id: GO:0003005
name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage
namespace: biological_process
def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
relationship: part_of GO:0048163 ! scattered antral spaces stage

[Term]
id: GO:0003006
name: developmental process involved in reproduction
namespace: biological_process
def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]
synonym: "puberty" NARROW [GOC:dph]
synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0003007
name: heart morphogenesis
namespace: biological_process
def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
synonym: "cardiac morphogenesis" RELATED []
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003008
name: system process
namespace: biological_process
def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
synonym: "organ system process" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003009
name: skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0003010
name: voluntary skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003011
name: involuntary skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003012
name: muscle system process
namespace: biological_process
def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
subset: goslim_drosophila
subset: goslim_generic
synonym: "muscle physiological process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003013
name: circulatory system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]
subset: goslim_chembl
subset: goslim_generic
xref: Wikipedia:Circulatory_system
is_a: GO:0003008 ! system process

[Term]
id: GO:0003014
name: renal system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]
subset: goslim_generic
synonym: "excretory system process" EXACT []
synonym: "kidney system process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003015
name: heart process
namespace: biological_process
def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
synonym: "cardiac process" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003016
name: respiratory system process
namespace: biological_process
alt_id: GO:0010802
def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]
subset: goslim_generic
synonym: "respiratory gaseous exchange" EXACT []
is_a: GO:0003008 ! system process
relationship: part_of GO:0007585 ! respiratory gaseous exchange by respiratory system

[Term]
id: GO:0003017
name: lymph circulation
namespace: biological_process
def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio]
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003018
name: vascular process in circulatory system
namespace: biological_process
def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio]
synonym: "vasculature process" EXACT []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003019
name: central nervous system control of baroreceptor feedback
namespace: biological_process
def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0003020
name: detection of reduced oxygen by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0070483 ! detection of hypoxia
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003021
name: detection of increased carbon dioxide by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003022
name: detection of pH by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003030 ! detection of hydrogen ion

[Term]
id: GO:0003023
name: baroreceptor detection of increased arterial stretch
namespace: biological_process
def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0003024
name: baroreceptor detection of decreased arterial stretch
namespace: biological_process
def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0003025
name: regulation of systemic arterial blood pressure by baroreceptor feedback
namespace: biological_process
def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003026
name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0003027
name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph]
synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah]
synonym: "vagal reflex" BROAD []
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003028
name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph]
synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003029
name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003030
name: detection of hydrogen ion
namespace: biological_process
def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003031
name: detection of carbon dioxide
namespace: biological_process
def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003032
name: detection of oxygen
namespace: biological_process
def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0003033
name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003034
name: detection of increased carbon dioxide by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003035
name: detection of increased carbon dioxide by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003036
name: detection of pH by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003037
name: detection of pH by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003038
name: detection of reduced oxygen by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003039
name: detection of reduced oxygen by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003040
name: excitation of vasomotor center by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003041
name: excitation of vasomotor center by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003042
name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951]
synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003043
name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio]
synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003044
name: regulation of systemic arterial blood pressure mediated by a chemical signal
namespace: biological_process
def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation mediated by a chemical signal" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003045
name: regulation of systemic arterial blood pressure by physical factors
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by physical factors" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003046
name: regulation of systemic arterial blood pressure by stress relaxation
namespace: biological_process
def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by stress relaxation" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0003047
name: regulation of systemic arterial blood pressure by epinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by epinephrine" RELATED []
synonym: "regulation of blood pressure by adrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003048
name: regulation of systemic arterial blood pressure by norepinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by norepinephrine" RELATED []
synonym: "regulation of blood pressure by noradrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003049
name: regulation of systemic arterial blood pressure by capillary fluid shift
namespace: biological_process
def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by capillary fluid shift" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors

[Term]
id: GO:0003050
name: regulation of systemic arterial blood pressure by atrial natriuretic peptide
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio]
synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio]
synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003051
name: angiotensin-mediated drinking behavior
namespace: biological_process
def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio]
synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042756 ! drinking behavior
relationship: part_of GO:0002035 ! brain renin-angiotensin system

[Term]
id: GO:0003052
name: circadian regulation of systemic arterial blood pressure
namespace: biological_process
def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0003053
name: circadian regulation of heart rate
namespace: biological_process
def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate" RELATED []
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003054
name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
namespace: biological_process
def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "master pacemaker clock regulation of blood pressure" EXACT []
synonym: "SCN regulation of blood pressure" EXACT []
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003055
name: circadian regulation of heart rate by the suprachiasmatic nucleus
namespace: biological_process
def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED []
synonym: "master pacemaker clock regulation of heart rate" EXACT []
synonym: "SCN regulation of heart rate" EXACT []
is_a: GO:0003053 ! circadian regulation of heart rate

[Term]
id: GO:0003056
name: regulation of vascular associated smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]
synonym: "regulation of vascular smooth muscle contraction" EXACT []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0019229 ! regulation of vasoconstriction
relationship: regulates GO:0014829 ! vascular associated smooth muscle contraction

[Term]
id: GO:0003057
name: regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl]
synonym: "chemical cardiac inotropy" EXACT []
synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0003058
name: hormonal regulation of the force of heart contraction
namespace: biological_process
def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac inotropy" EXACT []
synonym: "hormonal regulation of the force of heart muscle contraction" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal

[Term]
id: GO:0003059
name: positive regulation of the force of heart contraction by epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac inotropy" EXACT []
synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac inotropy" EXACT []
synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003060
name: negative regulation of the force of heart contraction by acetylcholine
namespace: biological_process
def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "decreased force of heart contraction by acetylcholine" EXACT []
is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003061
name: positive regulation of the force of heart contraction by norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl]
synonym: "increased force of heart contraction by adrenaline" RELATED []
synonym: "increased force of heart contraction by norepinephrine" EXACT []
synonym: "noradrenaline cardiac inotropy" EXACT []
synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac inotropy" EXACT []
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003062
name: regulation of heart rate by chemical signal
namespace: biological_process
def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb]
synonym: "chemical cardiac chronotropy" EXACT []
synonym: "chemical signal regulation of heart contraction rate" RELATED []
synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate

[Term]
id: GO:0003063
name: negative regulation of heart rate by acetylcholine
namespace: biological_process
def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003064
name: regulation of heart rate by hormone
namespace: biological_process
def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac chronotropy" EXACT []
synonym: "regulation of the rate of heart contraction by hormone" EXACT []
is_a: GO:0003062 ! regulation of heart rate by chemical signal

[Term]
id: GO:0003065
name: positive regulation of heart rate by epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac chronotropy" EXACT []
synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003066
name: positive regulation of heart rate by norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "noradrenaline cardiac chronotropy" EXACT []
synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" EXACT []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003067
name: circadian regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003068
name: regulation of systemic arterial blood pressure by acetylcholine
namespace: biological_process
def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl]
synonym: "blood pressure regulation by acetylcholine" EXACT []
is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter

[Term]
id: GO:0003069
name: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl]
synonym: "vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure" EXACT []
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003070
name: regulation of systemic arterial blood pressure by neurotransmitter
namespace: biological_process
def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0003071
name: renal system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "renal control of blood pressure" EXACT []
synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003014 ! renal system process
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003072
name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio]
synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistance" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003073
name: regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0003074
name: obsolete regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "regulation of diuresis" EXACT []
is_obsolete: true
consider: GO:0035809

[Term]
id: GO:0003075
name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio]
synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003077
name: obsolete negative regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "negative regulation of diuresis" EXACT []
is_obsolete: true
consider: GO:0035811

[Term]
id: GO:0003078
name: obsolete regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "regulation of natriuresis" EXACT []
is_obsolete: true
consider: GO:0035813

[Term]
id: GO:0003079
name: obsolete positive regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of natriuresis" EXACT []
is_obsolete: true
consider: GO:0035815

[Term]
id: GO:0003080
name: obsolete negative regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "negative regulation of natriuresis" EXACT []
is_obsolete: true
consider: GO:0035814

[Term]
id: GO:0003081
name: regulation of systemic arterial blood pressure by renin-angiotensin
namespace: biological_process
def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by renin-angiotensin" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003082
name: obsolete positive regulation of renal output by angiotensin
namespace: biological_process
def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of renal output by angiotensin" EXACT []
is_obsolete: true

[Term]
id: GO:0003083
name: negative regulation of renal output by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002019 ! regulation of renal output by angiotensin
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0003084
name: positive regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045777 ! positive regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003085
name: negative regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045776 ! negative regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003086
name: regulation of systemic arterial blood pressure by local renal renin-angiotensin
namespace: biological_process
def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0003087
name: positive regulation of the force of heart contraction by neuronal epinephrine
namespace: biological_process
def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine

[Term]
id: GO:0003088
name: positive regulation of the force of heart contraction by circulating epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline" RELATED []
synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine

[Term]
id: GO:0003089
name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003090
name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003091
name: renal water homeostasis
namespace: biological_process
def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio]
synonym: "water homeostasis by the renal system" EXACT []
is_a: GO:0003014 ! renal system process
is_a: GO:0050891 ! multicellular organismal-level water homeostasis

[Term]
id: GO:0003092
name: renal water retention
namespace: biological_process
def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio]
synonym: "negative regulation of renal water excretion" EXACT []
is_a: GO:0035811 ! negative regulation of urine volume

[Term]
id: GO:0003093
name: regulation of glomerular filtration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003094
name: glomerular filtration
namespace: biological_process
def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949]
is_a: GO:0097205 ! renal filtration

[Term]
id: GO:0003095
name: pressure natriuresis
namespace: biological_process
def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume

[Term]
id: GO:0003096
name: renal sodium ion transport
namespace: biological_process
def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006814 ! sodium ion transport

[Term]
id: GO:0003097
name: renal water transport
namespace: biological_process
def: "The directed movement of water (H2O) by the renal system." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006833 ! water transport
relationship: part_of GO:0003091 ! renal water homeostasis

[Term]
id: GO:0003098
name: tubuloglomerular feedback
namespace: biological_process
def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio]
xref: Wikipedia:Tubuloglomerular_feedback
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
relationship: part_of GO:0003093 ! regulation of glomerular filtration

[Term]
id: GO:0003099
name: positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045823 ! positive regulation of heart contraction

[Term]
id: GO:0003100
name: regulation of systemic arterial blood pressure by endothelin
namespace: biological_process
def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003101
name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
namespace: biological_process
def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003102
name: obsolete positive regulation of diuresis by angiotensin
namespace: biological_process
def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of diuresis by angiotensin" EXACT []
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0003103
name: obsolete positive regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of diuresis" EXACT []
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0003104
name: positive regulation of glomerular filtration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003105
name: negative regulation of glomerular filtration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003106
name: negative regulation of glomerular filtration by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb]
synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb]
synonym: "regulation of glomerular filtration by angiotensin" BROAD []
is_a: GO:0003083 ! negative regulation of renal output by angiotensin
relationship: part_of GO:0003105 ! negative regulation of glomerular filtration

[Term]
id: GO:0003107
name: obsolete positive regulation of natriuresis by angiotensin
namespace: biological_process
def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of natriuresis by angiotensin" EXACT []
is_obsolete: true

[Term]
id: GO:0003108
name: negative regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045822 ! negative regulation of heart contraction

[Term]
id: GO:0003109
name: positive regulation of the force of heart contraction by circulating norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating noradrenaline" RELATED []
synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003110
name: positive regulation of the force of heart contraction by neuronal norepinephrine
namespace: biological_process
def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003111
name: positive regulation of heart rate by circulating epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003112
name: positive regulation of heart rate by neuronal epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003113
name: positive regulation of heart rate by neuronal norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003114
name: positive regulation of heart rate by circulating norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003115
name: regulation of vasoconstriction by epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003116
name: regulation of vasoconstriction by norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003117
name: regulation of vasoconstriction by circulating norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003118
name: regulation of vasoconstriction by neuronal norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003119
name: regulation of vasoconstriction by neuronal epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003120
name: regulation of vasoconstriction by circulating epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003121
name: epinephrine-mediated vasodilation
namespace: biological_process
alt_id: GO:0003123
alt_id: GO:0003124
def: "A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by adrenaline" RELATED []
synonym: "regulation of vasodilation by circulating adrenaline" RELATED []
synonym: "regulation of vasodilation by circulating epinephrine" RELATED []
synonym: "regulation of vasodilation by epinephrine" RELATED []
synonym: "regulation of vasodilation by neuronal adrenaline" RELATED []
synonym: "regulation of vasodilation by neuronal epinephrine" RELATED []
is_a: GO:0042311 ! vasodilation

[Term]
id: GO:0003122
name: norepinephrine-mediated vasodilation
namespace: biological_process
alt_id: GO:0003125
alt_id: GO:0003126
def: "A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by circulating noradrenaline" RELATED []
synonym: "regulation of vasodilation by circulating norepinephrine" RELATED []
synonym: "regulation of vasodilation by neuronal noradrenaline" RELATED []
synonym: "regulation of vasodilation by neuronal norepinephrine" RELATED []
synonym: "regulation of vasodilation by noradrenaline" RELATED []
synonym: "regulation of vasodilation by norepinephrine" RELATED []
is_a: GO:0042311 ! vasodilation

[Term]
id: GO:0003127
name: detection of nodal flow
namespace: biological_process
def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart]
is_a: GO:0071495 ! cellular response to endogenous stimulus
relationship: part_of GO:0007368 ! determination of left/right symmetry

[Term]
id: GO:0003128
name: heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart]
is_a: GO:0010092 ! specification of animal organ identity
relationship: part_of GO:0060914 ! heart formation

[Term]
id: GO:0003129
name: heart induction
namespace: biological_process
def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart]
is_a: GO:0001759 ! organ induction
is_a: GO:2000826 ! regulation of heart morphogenesis
relationship: positively_regulates GO:0003128 ! heart field specification

[Term]
id: GO:0003130
name: obsolete BMP signaling pathway involved in heart induction
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003129
consider: GO:0030509

[Term]
id: GO:0003131
name: mesodermal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0003132
name: mesodermal-endodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah]
is_a: GO:0003131 ! mesodermal-endodermal cell signaling
relationship: part_of GO:0003129 ! heart induction

[Term]
id: GO:0003133
name: endodermal-mesodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0003134
name: endodermal-mesodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah]
is_a: GO:0003133 ! endodermal-mesodermal cell signaling
relationship: part_of GO:0003129 ! heart induction

[Term]
id: GO:0003135
name: obsolete fibroblast growth factor receptor signaling pathway involved in heart induction
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003129
consider: GO:0008543

[Term]
id: GO:0003136
name: obsolete negative regulation of heart induction by canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph]
synonym: "negative regulation of heart induction by canonical Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of heart induction by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060070
consider: GO:1901320

[Term]
id: GO:0003137
name: obsolete Notch signaling pathway involved in heart induction
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003129
consider: GO:0007219

[Term]
id: GO:0003138
name: primary heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl]
synonym: "FHS specification" EXACT [GOC:rl]
synonym: "first heart field specification" EXACT [GOC:rl]
is_a: GO:0003128 ! heart field specification

[Term]
id: GO:0003139
name: secondary heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708]
synonym: "anterior heart field specification" NARROW [GOC:mtg_heart]
synonym: "second heart field specification" EXACT [GOC:mtg_heart, PMID:17276708]
synonym: "SHF specification" EXACT [GOC:rl, PMID:22449840]
is_a: GO:0003128 ! heart field specification

[Term]
id: GO:0003140
name: determination of left/right asymmetry in lateral mesoderm
namespace: biological_process
def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0048368 ! lateral mesoderm development

[Term]
id: GO:0003141
name: obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart]
comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm.
synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
is_obsolete: true
consider: GO:0003140
consider: GO:0007179

[Term]
id: GO:0003142
name: cardiogenic plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]
synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003143
name: embryonic heart tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0035050 ! embryonic heart tube development
relationship: part_of GO:0048562 ! embryonic organ morphogenesis

[Term]
id: GO:0003144
name: embryonic heart tube formation
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis

[Term]
id: GO:0003145
name: embryonic heart tube formation via epithelial folding
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]
is_a: GO:0003144 ! embryonic heart tube formation

[Term]
id: GO:0003146
name: heart jogging
namespace: biological_process
def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285]
synonym: "cardiac jogging" EXACT [GOC:mtg_heart]
is_a: GO:0003143 ! embryonic heart tube morphogenesis
relationship: part_of GO:0061371 ! determination of heart left/right asymmetry

[Term]
id: GO:0003147
name: neural crest cell migration involved in heart formation
namespace: biological_process
def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060974 ! cell migration involved in heart formation
relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development

[Term]
id: GO:0003148
name: outflow tract septum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0003149
name: membranous septum morphogenesis
namespace: biological_process
def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis

[Term]
id: GO:0003150
name: muscular septum morphogenesis
namespace: biological_process
def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis

[Term]
id: GO:0003151
name: outflow tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding

[Term]
id: GO:0003153
name: closure of embryonic heart tube
namespace: biological_process
def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding

[Term]
id: GO:0003154
name: obsolete BMP signaling pathway involved in determination of left/right symmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph]
synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007368
consider: GO:0030509

[Term]
id: GO:0003155
name: obsolete BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT []
synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003140
consider: GO:0030509

[Term]
id: GO:0003156
name: regulation of animal organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0048645 ! animal organ formation

[Term]
id: GO:0003157
name: endocardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003158
name: endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development

[Term]
id: GO:0003159
name: morphogenesis of an endothelium
namespace: biological_process
def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0003158 ! endothelium development

[Term]
id: GO:0003160
name: endocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003157 ! endocardium development

[Term]
id: GO:0003161
name: cardiac conduction system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]
synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart]
synonym: "heart conduction system development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0003162
name: atrioventricular node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]
synonym: "AV node development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0003161 ! cardiac conduction system development

[Term]
id: GO:0003163
name: sinoatrial node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]
synonym: "SA node development" EXACT [GOC:mtg_heart]
synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0003228 ! atrial cardiac muscle tissue development
relationship: part_of GO:0003161 ! cardiac conduction system development

[Term]
id: GO:0003164
name: His-Purkinje system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
relationship: part_of GO:0003161 ! cardiac conduction system development

[Term]
id: GO:0003165
name: Purkinje myocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber development" EXACT []
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
relationship: part_of GO:0003164 ! His-Purkinje system development

[Term]
id: GO:0003166
name: bundle of His development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
relationship: part_of GO:0003164 ! His-Purkinje system development

[Term]
id: GO:0003167
name: atrioventricular bundle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003166 ! bundle of His development

[Term]
id: GO:0003168
name: Purkinje myocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber cell differentiation" EXACT []
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003165 ! Purkinje myocyte development

[Term]
id: GO:0003169
name: coronary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]
is_a: GO:0048845 ! venous blood vessel morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0003170
name: heart valve development
namespace: biological_process
def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]
synonym: "cardiac valve development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003171
name: atrioventricular valve development
namespace: biological_process
def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "AV valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003172
name: sinoatrial valve development
namespace: biological_process
def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "SA valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003173
name: ventriculo bulbo valve development
namespace: biological_process
def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003174
name: mitral valve development
namespace: biological_process
def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003171 ! atrioventricular valve development

[Term]
id: GO:0003175
name: tricuspid valve development
namespace: biological_process
def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003171 ! atrioventricular valve development

[Term]
id: GO:0003176
name: aortic valve development
namespace: biological_process
def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:1905314 ! semi-lunar valve development

[Term]
id: GO:0003177
name: pulmonary valve development
namespace: biological_process
def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:1905314 ! semi-lunar valve development

[Term]
id: GO:0003178
name: coronary sinus valve development
namespace: biological_process
def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003179
name: heart valve morphogenesis
namespace: biological_process
def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart]
synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf]
synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003170 ! heart valve development

[Term]
id: GO:0003180
name: aortic valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003176 ! aortic valve development

[Term]
id: GO:0003181
name: atrioventricular valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart]
synonym: "AV valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003171 ! atrioventricular valve development

[Term]
id: GO:0003182
name: coronary sinus valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003178 ! coronary sinus valve development

[Term]
id: GO:0003183
name: mitral valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003181 ! atrioventricular valve morphogenesis
relationship: part_of GO:0003174 ! mitral valve development

[Term]
id: GO:0003184
name: pulmonary valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003177 ! pulmonary valve development

[Term]
id: GO:0003185
name: sinoatrial valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart]
synonym: "SA valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003172 ! sinoatrial valve development

[Term]
id: GO:0003186
name: tricuspid valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003181 ! atrioventricular valve morphogenesis
relationship: part_of GO:0003175 ! tricuspid valve development

[Term]
id: GO:0003187
name: ventriculo bulbo valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003173 ! ventriculo bulbo valve development

[Term]
id: GO:0003188
name: heart valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis

[Term]
id: GO:0003189
name: aortic valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003180 ! aortic valve morphogenesis

[Term]
id: GO:0003190
name: atrioventricular valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "AV valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis

[Term]
id: GO:0003191
name: coronary sinus valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis

[Term]
id: GO:0003192
name: mitral valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003190 ! atrioventricular valve formation
relationship: part_of GO:0003183 ! mitral valve morphogenesis

[Term]
id: GO:0003193
name: pulmonary valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003184 ! pulmonary valve morphogenesis

[Term]
id: GO:0003194
name: sinoatrial valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "SA valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis

[Term]
id: GO:0003195
name: tricuspid valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003190 ! atrioventricular valve formation
relationship: part_of GO:0003186 ! tricuspid valve morphogenesis

[Term]
id: GO:0003196
name: ventriculo bulbo valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis

[Term]
id: GO:0003197
name: endocardial cushion development
namespace: biological_process
def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003198
name: epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0003272 ! endocardial cushion formation

[Term]
id: GO:0003199
name: endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart]
synonym: "endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:bf]
is_a: GO:0090500 ! endocardial cushion to mesenchymal transition
relationship: part_of GO:0003188 ! heart valve formation

[Term]
id: GO:0003200
name: endocardial cushion to mesenchymal transition involved in heart chamber septation
namespace: biological_process
def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart]
is_a: GO:0090500 ! endocardial cushion to mesenchymal transition
relationship: part_of GO:0060411 ! cardiac septum morphogenesis

[Term]
id: GO:0003201
name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0003202
name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart]
is_a: GO:0090500 ! endocardial cushion to mesenchymal transition
relationship: part_of GO:0003204 ! cardiac skeleton development

[Term]
id: GO:0003203
name: endocardial cushion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003197 ! endocardial cushion development

[Term]
id: GO:0003204
name: cardiac skeleton development
namespace: biological_process
def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]
synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003205
name: cardiac chamber development
namespace: biological_process
def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003206
name: cardiac chamber morphogenesis
namespace: biological_process
def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003207
name: cardiac chamber formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:0003208
name: cardiac ventricle morphogenesis
namespace: biological_process
def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003231 ! cardiac ventricle development

[Term]
id: GO:0003209
name: cardiac atrium morphogenesis
namespace: biological_process
def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003230 ! cardiac atrium development

[Term]
id: GO:0003210
name: cardiac atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis

[Term]
id: GO:0003211
name: cardiac ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis

[Term]
id: GO:0003212
name: cardiac left atrium morphogenesis
namespace: biological_process
def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis

[Term]
id: GO:0003213
name: cardiac right atrium morphogenesis
namespace: biological_process
def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis

[Term]
id: GO:0003214
name: cardiac left ventricle morphogenesis
namespace: biological_process
def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis

[Term]
id: GO:0003215
name: cardiac right ventricle morphogenesis
namespace: biological_process
def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis

[Term]
id: GO:0003216
name: cardiac left atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis

[Term]
id: GO:0003217
name: cardiac right atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis

[Term]
id: GO:0003218
name: cardiac left ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis

[Term]
id: GO:0003219
name: cardiac right ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis

[Term]
id: GO:0003220
name: left ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis

[Term]
id: GO:0003221
name: right ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis

[Term]
id: GO:0003222
name: ventricular trabecula myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
is_a: GO:0061384 ! heart trabecula morphogenesis

[Term]
id: GO:0003223
name: ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis

[Term]
id: GO:0003224
name: left ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis

[Term]
id: GO:0003225
name: left ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis

[Term]
id: GO:0003226
name: right ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis

[Term]
id: GO:0003227
name: right ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis

[Term]
id: GO:0003228
name: atrial cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "atrial myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0003229
name: ventricular cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0003230
name: cardiac atrium development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003231
name: cardiac ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003232
name: bulbus arteriosus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003233
name: bulbus arteriosus morphogenesis
namespace: biological_process
def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003232 ! bulbus arteriosus development

[Term]
id: GO:0003234
name: bulbus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis

[Term]
id: GO:0003235
name: sinus venosus development
namespace: biological_process
def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003236
name: sinus venosus morphogenesis
namespace: biological_process
def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003235 ! sinus venosus development

[Term]
id: GO:0003237
name: sinus venosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003236 ! sinus venosus morphogenesis

[Term]
id: GO:0003238
name: conus arteriosus development
namespace: biological_process
def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003239
name: conus arteriosus morphogenesis
namespace: biological_process
def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003238 ! conus arteriosus development

[Term]
id: GO:0003240
name: conus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003239 ! conus arteriosus morphogenesis

[Term]
id: GO:0003241
name: growth involved in heart morphogenesis
namespace: biological_process
def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0060419 ! heart growth

[Term]
id: GO:0003242
name: cardiac chamber ballooning
namespace: biological_process
def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:0003243
name: circumferential growth involved in left ventricle morphogenesis
namespace: biological_process
def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis

[Term]
id: GO:0003244
name: radial growth involved in right ventricle morphogenesis
namespace: biological_process
def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis

[Term]
id: GO:0003245
name: cardiac muscle tissue growth involved in heart morphogenesis
namespace: biological_process
def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0055017 ! cardiac muscle tissue growth
relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis

[Term]
id: GO:0003246
name: embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart]
synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis

[Term]
id: GO:0003247
name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis

[Term]
id: GO:0003248
name: heart capillary growth
namespace: biological_process
def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0060419 ! heart growth
relationship: part_of GO:0060976 ! coronary vasculature development

[Term]
id: GO:0003249
name: cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
is_a: GO:2000793 ! cell proliferation involved in heart valve development
relationship: part_of GO:0003179 ! heart valve morphogenesis

[Term]
id: GO:0003250
name: regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis

[Term]
id: GO:0003251
name: positive regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis

[Term]
id: GO:0003252
name: negative regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis
relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis

[Term]
id: GO:0003253
name: cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis

[Term]
id: GO:0003254
name: regulation of membrane depolarization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051899 ! membrane depolarization

[Term]
id: GO:0003255
name: endocardial precursor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0003256
name: obsolete regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0003257
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0003258
name: obsolete regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0003259
name: cardioblast anterior-lateral migration
namespace: biological_process
def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003260 ! cardioblast migration

[Term]
id: GO:0003260
name: cardioblast migration
namespace: biological_process
def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0060974 ! cell migration involved in heart formation

[Term]
id: GO:0003261
name: cardiac muscle progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart]
synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation

[Term]
id: GO:0003262
name: endocardial progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation

[Term]
id: GO:0003263
name: cardioblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: part_of GO:0060914 ! heart formation

[Term]
id: GO:0003264
name: regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
relationship: regulates GO:0003263 ! cardioblast proliferation

[Term]
id: GO:0003265
name: regulation of primary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl]
synonym: "regulation of FHF cardioblast proliferation" EXACT [GOC:rl]
synonym: "regulation of first heart field cardiac proliferation" RELATED []
synonym: "regulation of first heart field cardioblast proliferation" EXACT [GOC:rl]
is_a: GO:0003264 ! regulation of cardioblast proliferation

[Term]
id: GO:0003266
name: regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708]
synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "regulation of SHF cardioblast proliferation" EXACT [GOC:rl]
is_a: GO:0003264 ! regulation of cardioblast proliferation

[Term]
id: GO:0003267
name: obsolete canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "OBSOLETE. A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" RELATED [GOC:signaling]
is_obsolete: true
consider: GO:0060070
consider: GO:0072513

[Term]
id: GO:0003268
name: obsolete fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph]
synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0003269
name: obsolete BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003266
consider: GO:0030509

[Term]
id: GO:0003270
name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph]
synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0061314 ! Notch signaling involved in heart development
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation

[Term]
id: GO:0003271
name: smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:bf]
synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation

[Term]
id: GO:0003272
name: endocardial cushion formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:0003273
name: cell migration involved in endocardial cushion formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003272 ! endocardial cushion formation

[Term]
id: GO:0003274
name: endocardial cushion fusion
namespace: biological_process
def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart]
is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:0003275
name: apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in outflow tract morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0003276
name: apoptotic process involved in heart valve morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in heart valve morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis

[Term]
id: GO:0003277
name: apoptotic process involved in endocardial cushion morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:0003278
name: apoptotic process involved in heart morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in heart morphogenesis" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003279
name: cardiac septum development
namespace: biological_process
def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
synonym: "heart septum development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003281
name: ventricular septum development
namespace: biological_process
def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]
synonym: "interventricular septum development" EXACT [GOC:mtg_heart]
synonym: "septum inferius development" NARROW [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003231 ! cardiac ventricle development

[Term]
id: GO:0003282
name: ventricular septum intermedium development
namespace: biological_process
def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003281 ! ventricular septum development

[Term]
id: GO:0003283
name: atrial septum development
namespace: biological_process
def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003230 ! cardiac atrium development

[Term]
id: GO:0003284
name: septum primum development
namespace: biological_process
def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development

[Term]
id: GO:0003285
name: septum secundum development
namespace: biological_process
def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development

[Term]
id: GO:0003286
name: atrial septum intermedium development
namespace: biological_process
def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development

[Term]
id: GO:0003288
name: ventricular septum intermedium morphogenesis
namespace: biological_process
def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060412 ! ventricular septum morphogenesis

[Term]
id: GO:0003289
name: atrial septum primum morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003284 ! septum primum development

[Term]
id: GO:0003290
name: atrial septum secundum morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003285 ! septum secundum development

[Term]
id: GO:0003291
name: atrial septum intermedium morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003286 ! atrial septum intermedium development

[Term]
id: GO:0003292
name: cardiac septum cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0003279 ! cardiac septum development

[Term]
id: GO:0003293
name: heart valve cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0003170 ! heart valve development

[Term]
id: GO:0003294
name: atrial ventricular junction remodeling
namespace: biological_process
def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart]
synonym: "atrial ventricular junction remodelling" EXACT []
synonym: "atrio-ventricular junction remodeling" RELATED [GOC:mtg_heart]
synonym: "atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003295
name: cell proliferation involved in atrial ventricular junction remodeling
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart]
synonym: "cell proliferation involved in atrial ventricular junction remodelling" EXACT []
synonym: "cell proliferation involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "cell proliferation involved in atrio-ventricular junction remodelling" EXACT []
synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "cell proliferation involved in atrioventricular junction remodelling" EXACT []
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling

[Term]
id: GO:0003296
name: apoptotic process involved in atrial ventricular junction remodeling
namespace: biological_process
def: "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in atrial ventricular junction remodelling" EXACT []
synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "apoptosis involved in atrio-ventricular junction remodelling" EXACT []
synonym: "apoptosis involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "apoptosis involved in atrioventricular junction remodelling" EXACT []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling

[Term]
id: GO:0003297
name: heart wedging
namespace: biological_process
def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003298
name: physiological muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart]
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0003299
name: muscle hypertrophy in response to stress
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart]
is_a: GO:0006950 ! response to stress
is_a: GO:0014896 ! muscle hypertrophy
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0003300
name: cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]
is_a: GO:0014897 ! striated muscle hypertrophy

[Term]
id: GO:0003301
name: physiological cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
is_a: GO:0003298 ! physiological muscle hypertrophy
is_a: GO:0003300 ! cardiac muscle hypertrophy
relationship: part_of GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0003302
name: obsolete transforming growth factor beta receptor signaling pathway involved in heart jogging
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0003303
name: obsolete BMP signaling pathway involved in heart jogging
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003146
consider: GO:0030509

[Term]
id: GO:0003304
name: myocardial epithelial involution involved in heart jogging
namespace: biological_process
def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0003146 ! heart jogging

[Term]
id: GO:0003305
name: cell migration involved in heart jogging
namespace: biological_process
def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003146 ! heart jogging

[Term]
id: GO:0003306
name: Wnt signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development

[Term]
id: GO:0003307
name: regulation of Wnt signaling pathway involved in heart development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "regulation of Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
relationship: regulates GO:0003306 ! Wnt signaling pathway involved in heart development

[Term]
id: GO:0003308
name: negative regulation of Wnt signaling pathway involved in heart development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "negative regulation of Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development

[Term]
id: GO:0003309
name: type B pancreatic cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772]
synonym: "pancreatic B cell differentiation" EXACT [GOC:mah]
synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003310
name: pancreatic A cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772]
synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003311
name: pancreatic D cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772]
synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003312
name: pancreatic PP cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772]
synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003313
name: heart rudiment development
namespace: biological_process
def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart]
synonym: "heart cone development" EXACT [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0003314
name: heart rudiment morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart]
synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003313 ! heart rudiment development

[Term]
id: GO:0003315
name: heart rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart]
synonym: "heart cone formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003314 ! heart rudiment morphogenesis

[Term]
id: GO:0003316
name: establishment of myocardial progenitor cell apical/basal polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity
relationship: part_of GO:0003315 ! heart rudiment formation

[Term]
id: GO:0003317
name: cardioblast cell midline fusion
namespace: biological_process
def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart]
is_a: GO:0034109 ! homotypic cell-cell adhesion
is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis
relationship: part_of GO:0003315 ! heart rudiment formation

[Term]
id: GO:0003318
name: cell migration to the midline involved in heart development
namespace: biological_process
def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development

[Term]
id: GO:0003319
name: cardioblast migration to the midline involved in heart rudiment formation
namespace: biological_process
def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart]
is_a: GO:0003318 ! cell migration to the midline involved in heart development
relationship: part_of GO:0003315 ! heart rudiment formation

[Term]
id: GO:0003320
name: heart rudiment involution
namespace: biological_process
def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart]
is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation

[Term]
id: GO:0003321
name: positive regulation of blood pressure by epinephrine-norepinephrine
namespace: biological_process
def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph]
is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine
is_a: GO:0045777 ! positive regulation of blood pressure

[Term]
id: GO:0003322
name: pancreatic A cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
synonym: "pancreatic alpha cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003310 ! pancreatic A cell differentiation

[Term]
id: GO:0003323
name: type B pancreatic cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]
synonym: "pancreatic B cell development" EXACT [GOC:mah]
synonym: "pancreatic beta cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003309 ! type B pancreatic cell differentiation

[Term]
id: GO:0003324
name: pancreatic D cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
synonym: "pancreatic delta cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003311 ! pancreatic D cell differentiation

[Term]
id: GO:0003325
name: pancreatic PP cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation

[Term]
id: GO:0003326
name: pancreatic A cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003310 ! pancreatic A cell differentiation

[Term]
id: GO:0003327
name: type B pancreatic cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]
synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003309 ! type B pancreatic cell differentiation

[Term]
id: GO:0003328
name: pancreatic D cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003311 ! pancreatic D cell differentiation

[Term]
id: GO:0003329
name: pancreatic PP cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation

[Term]
id: GO:0003330
name: regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:1903053 ! regulation of extracellular matrix organization
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: GO:0003331
name: positive regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: GO:0003332
name: negative regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: GO:0003333
name: amino acid transmembrane transport
namespace: biological_process
def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "amino acid membrane transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0003334
name: keratinocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0003335
name: corneocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003334 ! keratinocyte development

[Term]
id: GO:0003336
name: corneocyte desquamation
namespace: biological_process
def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph]
synonym: "epidermal desquamation" EXACT [GOC:dph]
is_a: GO:0060232 ! delamination
relationship: part_of GO:0003335 ! corneocyte development

[Term]
id: GO:0003337
name: mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0060231 ! mesenchymal to epithelial transition
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis

[Term]
id: GO:0003338
name: metanephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0003339
name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis

[Term]
id: GO:0003340
name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis

[Term]
id: GO:0003341
name: cilium movement
namespace: biological_process
alt_id: GO:0036142
def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliary motility" RELATED []
synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "flagellar motility" RELATED []
synonym: "flagellar movement" NARROW [GOC:bf]
synonym: "flagellum movement" NARROW []
synonym: "microtubule-based flagellum movement" EXACT []
is_a: GO:0007018 ! microtubule-based movement

[Term]
id: GO:0003342
name: proepicardium development
namespace: biological_process
def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0003343 ! septum transversum development

[Term]
id: GO:0003343
name: septum transversum development
namespace: biological_process
def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development

[Term]
id: GO:0003344
name: pericardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060039 ! pericardium development

[Term]
id: GO:0003345
name: proepicardium cell migration involved in pericardium morphogenesis
namespace: biological_process
def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003344 ! pericardium morphogenesis

[Term]
id: GO:0003346
name: epicardium-derived cell migration to the myocardium
namespace: biological_process
def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343]
is_a: GO:0060973 ! cell migration involved in heart development

[Term]
id: GO:0003347
name: epicardial cell to mesenchymal cell transition
namespace: biological_process
def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343]
is_a: GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0003348
name: cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0003349
name: epicardium-derived cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0003348 ! cardiac endothelial cell differentiation

[Term]
id: GO:0003350
name: pulmonary myocardium development
namespace: biological_process
def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577]
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0060841 ! venous blood vessel development

[Term]
id: GO:0003351
name: epithelial cilium movement involved in extracellular fluid movement
namespace: biological_process
def: "The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid." [GOC:dph, GOC:krc]
synonym: "cilium movement involved in fluid flow" RELATED [GOC:cilia]
synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
is_a: GO:0006858 ! extracellular transport
is_a: GO:0099111 ! microtubule-based transport

[Term]
id: GO:0003352
name: regulation of cilium movement
namespace: biological_process
alt_id: GO:1900172
def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "regulation of flagellum movement" RELATED []
synonym: "regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0003341 ! cilium movement

[Term]
id: GO:0003353
name: positive regulation of cilium movement
namespace: biological_process
alt_id: GO:1900174
def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "positive regulation of flagellum movement" RELATED []
synonym: "positive regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0003341 ! cilium movement

[Term]
id: GO:0003354
name: negative regulation of cilium movement
namespace: biological_process
alt_id: GO:1900173
def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "negative regulation of flagellum movement" RELATED []
synonym: "negative regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0003341 ! cilium movement

[Term]
id: GO:0003355
name: cilium movement involved in otolith formation
namespace: biological_process
def: "The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles." [GOC:dph, GOC:krc, PMID:19043402]
is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement
relationship: part_of GO:0032475 ! otolith formation

[Term]
id: GO:0003356
name: regulation of cilium beat frequency
namespace: biological_process
alt_id: GO:0036144
def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "regulation of flagellum beat frequency" RELATED []
synonym: "regulation of microtubule-based flagellum beat frequency" EXACT []
is_a: GO:0003352 ! regulation of cilium movement

[Term]
id: GO:0003357
name: noradrenergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph]
synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0003358
name: noradrenergic neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation

[Term]
id: GO:0003359
name: noradrenergic neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph]
synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation

[Term]
id: GO:0003360
name: brainstem development
namespace: biological_process
def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0003361
name: noradrenergic neuron differentiation involved in brainstem development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003357 ! noradrenergic neuron differentiation
relationship: part_of GO:0003360 ! brainstem development

[Term]
id: GO:0003362
name: noradrenergic neuron fate commitment involved in brainstem development
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003359 ! noradrenergic neuron fate commitment
relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development

[Term]
id: GO:0003363
name: lamellipodium assembly involved in ameboidal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030032 ! lamellipodium assembly
relationship: part_of GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0003364
name: lamellipodium assembly involved in mesendodermal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration

[Term]
id: GO:0003365
name: establishment of cell polarity involved in ameboidal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0003366
name: cell-matrix adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0003367
name: cell-cell adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration

[Term]
id: GO:0003368
name: cell-matrix adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration

[Term]
id: GO:0003369
name: establishment of cell polarity involved in mesendodermal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration

[Term]
id: GO:0003370
name: cell-cell adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration
is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration

[Term]
id: GO:0003371
name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration

[Term]
id: GO:0003372
name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration

[Term]
id: GO:0003373
name: obsolete dynamin family protein polymerization involved in membrane fission
namespace: biological_process
def: "OBSOLETE. The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0003374
name: obsolete dynamin family protein polymerization involved in mitochondrial fission
namespace: biological_process
def: "OBSOLETE. The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0003375
name: obsolete regulation of dynamin family protein polymerization involved in membrane fission
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0003376
name: sphingosine-1-phosphate receptor signaling pathway
namespace: biological_process
alt_id: GO:0001789
def: "A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186]
synonym: "S1P receptor signaling pathway" EXACT [GOC:bf]
synonym: "S1P signaling pathway" RELATED [GOC:bf]
synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf]
synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf]
synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186]
synonym: "sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "sphingolipid signalling pathway" BROAD [GOC:mah]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0090520 ! sphingolipid mediated signaling pathway

[Term]
id: GO:0003377
name: obsolete regulation of apoptosis by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah]
is_obsolete: true

[Term]
id: GO:0003378
name: obsolete regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah]
is_obsolete: true

[Term]
id: GO:0003379
name: establishment of cell polarity involved in gastrulation cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
relationship: part_of GO:0042074 ! cell migration involved in gastrulation

[Term]
id: GO:0003380
name: establishment or maintenance of cytoskeleton polarity involved in gastrulation
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration

[Term]
id: GO:0003381
name: epithelial cell morphogenesis involved in gastrulation
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0003382
name: epithelial cell morphogenesis
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0002064 ! epithelial cell development

[Term]
id: GO:0003383
name: apical constriction
namespace: biological_process
def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0003382 ! epithelial cell morphogenesis

[Term]
id: GO:0003384
name: apical constriction involved in gastrulation
namespace: biological_process
def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003383 ! apical constriction
relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation

[Term]
id: GO:0003385
name: obsolete cell-cell signaling involved in amphid sensory organ development
namespace: biological_process
def: "OBSOLETE. Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0003386
name: amphid sensory organ development
namespace: biological_process
def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0003387
name: neuron differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0003386 ! amphid sensory organ development

[Term]
id: GO:0003388
name: neuron development involved in amphid sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development

[Term]
id: GO:0003389
name: retrograde extension
namespace: biological_process
def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031175 ! neuron projection development

[Term]
id: GO:0003390
name: dendrite development by retrograde extension
namespace: biological_process
def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003389 ! retrograde extension
is_a: GO:0016358 ! dendrite development

[Term]
id: GO:0003391
name: amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development

[Term]
id: GO:0003392
name: cell adhesion involved in retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007155 ! cell adhesion
relationship: part_of GO:0003389 ! retrograde extension

[Term]
id: GO:0003393
name: neuron migration involved in retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001764 ! neuron migration
relationship: part_of GO:0003389 ! retrograde extension

[Term]
id: GO:0003394
name: cell adhesion involved in dendrite retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003392 ! cell adhesion involved in retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension

[Term]
id: GO:0003395
name: neuron migration involved in dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003393 ! neuron migration involved in retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension

[Term]
id: GO:0003396
name: cell adhesion involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension

[Term]
id: GO:0003397
name: neuron migration involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension

[Term]
id: GO:0003398
name: glial cell differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0003386 ! amphid sensory organ development

[Term]
id: GO:0003399
name: cytoneme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis

[Term]
id: GO:0003400
name: regulation of COPII vesicle coating
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0048208 ! COPII vesicle coating

[Term]
id: GO:0003401
name: axis elongation
namespace: biological_process
def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis

[Term]
id: GO:0003402
name: obsolete planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0003403
name: optic vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0003404
name: optic vesicle morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis

[Term]
id: GO:0003405
name: optic vesicle elongation
namespace: biological_process
def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis

[Term]
id: GO:0003406
name: retinal pigment epithelium development
namespace: biological_process
def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0003407
name: neural retina development
namespace: biological_process
def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0003408
name: optic cup formation involved in camera-type eye development
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development

[Term]
id: GO:0003409
name: optic cup structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "optic cup structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development

[Term]
id: GO:0003410
name: anterior rotation of the optic cup
namespace: biological_process
def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0003411
name: cell motility involved in camera-type eye morphogenesis
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0003412
name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0003413
name: chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002062 ! chondrocyte differentiation
relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis

[Term]
id: GO:0003414
name: chondrocyte morphogenesis involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090171 ! chondrocyte morphogenesis
relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis

[Term]
id: GO:0003415
name: chondrocyte hypertrophy
namespace: biological_process
def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0002063 ! chondrocyte development

[Term]
id: GO:0003416
name: endochondral bone growth
namespace: biological_process
def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098868 ! bone growth

[Term]
id: GO:0003417
name: growth plate cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0003416 ! endochondral bone growth

[Term]
id: GO:0003418
name: growth plate cartilage chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development

[Term]
id: GO:0003419
name: growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0003417 ! growth plate cartilage development

[Term]
id: GO:0003420
name: regulation of growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation

[Term]
id: GO:0003421
name: growth plate cartilage axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis

[Term]
id: GO:0003422
name: growth plate cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development

[Term]
id: GO:0003423
name: growth plate cartilage chondrocyte division
namespace: biological_process
def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation

[Term]
id: GO:0003424
name: establishment of cell polarity involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division

[Term]
id: GO:0003425
name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000132 ! establishment of mitotic spindle orientation
is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division
is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity

[Term]
id: GO:0003426
name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division

[Term]
id: GO:0003427
name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
is_a: GO:0051493 ! regulation of cytoskeleton organization
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division

[Term]
id: GO:0003428
name: chondrocyte intercalation involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0060029 ! convergent extension involved in organogenesis

[Term]
id: GO:0003429
name: growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis
is_a: GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation

[Term]
id: GO:0003430
name: growth plate cartilage chondrocyte growth
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003415 ! chondrocyte hypertrophy
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development

[Term]
id: GO:0003431
name: growth plate cartilage chondrocyte development
namespace: biological_process
def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation

[Term]
id: GO:0003432
name: cell growth involved in growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003430 ! growth plate cartilage chondrocyte growth
relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis

[Term]
id: GO:0003433
name: chondrocyte development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002063 ! chondrocyte development
relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis

[Term]
id: GO:0003434
name: obsolete BMP signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003431
consider: GO:0030509

[Term]
id: GO:0003435
name: obsolete smoothened signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0003436
name: regulation of cell adhesion involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis

[Term]
id: GO:0003437
name: regulation of cell communication involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis

[Term]
id: GO:0003673
name: obsolete Gene_Ontology
namespace: biological_process
def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "Gene_Ontology" EXACT []
is_obsolete: true

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "molecular function" EXACT []

[Term]
id: GO:0003675
name: obsolete protein
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003676
name: nucleic acid binding
namespace: molecular_function
alt_id: GO:0000496
def: "Binding to a nucleic acid." [GOC:jl]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
synonym: "base pairing" NARROW []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0003677
name: DNA binding
namespace: molecular_function
alt_id: GO:0043566
def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "plasmid binding" NARROW []
synonym: "structure specific DNA binding" RELATED []
synonym: "structure-specific DNA binding" RELATED []
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003678
name: DNA helicase activity
namespace: molecular_function
alt_id: GO:0003679
alt_id: GO:0004003
def: "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]
synonym: "ATP-dependent DNA helicase activity" EXACT []
xref: Reactome:R-HSA-5693589 "D-loop dissociation and strand annealing"
is_a: GO:0004386 ! helicase activity
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0003680
name: minor groove of adenine-thymine-rich DNA binding
namespace: molecular_function
def: "Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins." [GOC:jl, PMID:10545119, PMID:15802641, PMID:26223912, PMID:2670564]
synonym: "AT binding" EXACT []
synonym: "AT DNA binding" EXACT []
synonym: "AT-rich DNA binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0003681
name: bent DNA binding
namespace: molecular_function
def: "Binding to DNA in a bent conformation." [GOC:jl, PMID:12627977]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003682
name: chromatin binding
namespace: molecular_function
def: "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "lamin/chromatin binding" NARROW []
synonym: "microtubule/chromatin interaction" NARROW []
synonym: "nuclear membrane vesicle binding to chromatin" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003683
name: obsolete lamin/chromatin binding
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two functions.
synonym: "lamin/chromatin binding" EXACT []
is_obsolete: true
consider: GO:0003682
consider: GO:0005521

[Term]
id: GO:0003684
name: damaged DNA binding
namespace: molecular_function
def: "Binding to damaged DNA." [GOC:jl]
synonym: "DNA repair enzyme" RELATED []
synonym: "DNA repair protein" RELATED []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003685
name: obsolete DNA repair protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
synonym: "DNA repair protein" EXACT []
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003686
name: obsolete DNA repair enzyme
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
synonym: "DNA repair enzyme" EXACT []
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003687
name: obsolete DNA replication factor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA replication factor" EXACT []
is_obsolete: true
consider: GO:0006260

[Term]
id: GO:0003688
name: DNA replication origin binding
namespace: molecular_function
def: "Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators]
synonym: "ARS binding" NARROW []
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0003689
name: DNA clamp loader activity
namespace: molecular_function
alt_id: GO:0033170
def: "Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis." [GOC:mah, GOC:vw, PMID:16082778]
synonym: "DNA clamp loading ATPase activity" EXACT []
synonym: "DNA-protein loading ATPase activity" RELATED [GOC:mah]
synonym: "PCNA loading activity" NARROW []
synonym: "PCNA loading complex activity" NARROW []
synonym: "protein-DNA loading ATPase activity" RELATED []
xref: Reactome:R-HSA-174439 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:R-HSA-176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0003690
name: double-stranded DNA binding
namespace: molecular_function
def: "Binding to double-stranded DNA." [GOC:elh, GOC:vw]
synonym: "dsDNA binding" EXACT [GOC:elh]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003691
name: double-stranded telomeric DNA binding
namespace: molecular_function
def: "Binding to double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0042162 ! telomeric DNA binding

[Term]
id: GO:0003692
name: left-handed Z-DNA binding
namespace: molecular_function
def: "Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094]
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0003693
name: P-element binding
namespace: molecular_function
def: "Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0003694
name: obsolete plasmid binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732]
comment: This term was made obsolete because it refers to component information.
synonym: "plasmid binding" EXACT []
synonym: "plasmid-associated protein" RELATED []
is_obsolete: true
consider: GO:0003677
consider: GO:0005727

[Term]
id: GO:0003695
name: obsolete random coil DNA binding
namespace: molecular_function
alt_id: GO:0016017
def: "OBSOLETE. Binding to DNA in a random coil configuration." [GOC:mah]
comment: This term was obsoleted because the definition was not clear enough as to what is directing specificity of the binding to the DNA.
synonym: "random coil binding" EXACT []
is_obsolete: true

[Term]
id: GO:0003696
name: satellite DNA binding
namespace: molecular_function
def: "Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0003697
name: single-stranded DNA binding
namespace: molecular_function
alt_id: GO:0003698
alt_id: GO:0003699
def: "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]
comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA.
synonym: "ssDNA binding" EXACT [GOC:mah]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003700
name: DNA-binding transcription factor activity
namespace: molecular_function
alt_id: GO:0000130
alt_id: GO:0001071
alt_id: GO:0001130
alt_id: GO:0001131
alt_id: GO:0001151
alt_id: GO:0001199
alt_id: GO:0001204
def: "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]
comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_plant
subset: goslim_yeast
synonym: "bacterial-type DNA binding transcription factor activity" NARROW []
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW []
synonym: "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" NARROW []
synonym: "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding" NARROW []
synonym: "DNA binding transcription factor activity" EXACT []
synonym: "gene-specific transcription factor activity" EXACT []
synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity" NARROW []
synonym: "nucleic acid binding transcription factor activity" BROAD []
synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW []
synonym: "sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "transcription factor activity" BROAD []
synonym: "transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW []
synonym: "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW []
synonym: "transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding" NARROW []
synonym: "transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW []
xref: Reactome:R-HSA-163666 "Formation of ChREBP:MLX heterodimer"
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0003701
name: obsolete RNA polymerase I transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "RNA polymerase I transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0001181
consider: GO:0006360

[Term]
id: GO:0003702
name: obsolete RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "RNA polymerase II transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0006366

[Term]
id: GO:0003704
name: obsolete specific RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "specific RNA polymerase II transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0006366

[Term]
id: GO:0003706
name: obsolete ligand-regulated transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators]
comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism.
synonym: "ligand-regulated transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0003713
consider: GO:0004879

[Term]
id: GO:0003707
name: nuclear steroid receptor activity
namespace: molecular_function
def: "A nuclear receptor activity regulated by steroid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:signaling, PMID:14708019]
synonym: "steroid hormone receptor activity" BROAD []
is_a: GO:0004879 ! nuclear receptor activity

[Term]
id: GO:0003709
name: obsolete RNA polymerase III transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "RNA polymerase III transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000995
consider: GO:0006383

[Term]
id: GO:0003711
name: transcription elongation factor activity
namespace: molecular_function
def: "A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases." [GOC:txnOH-2018, PMID:23878398, PMID:28892040]
comment: Restored term from obsolete.
synonym: "transcription elongation regulator activity" RELATED []
synonym: "transcriptional elongation regulator activity" RELATED []
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0003712
name: transcription coregulator activity
namespace: molecular_function
alt_id: GO:0001104
alt_id: GO:0016455
def: "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]
comment: Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.
subset: goslim_drosophila
synonym: "nuclear receptor coreceptor activity" NARROW []
synonym: "RNA polymerase II transcriptional cofactor activity" RELATED []
synonym: "transcription cofactor activity" EXACT []
synonym: "transcription coreceptor activity" EXACT []
synonym: "transcriptional co-regulator" EXACT []
is_a: GO:0030674 ! protein-macromolecule adaptor activity
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0003713
name: transcription coactivator activity
namespace: molecular_function
alt_id: GO:0001105
def: "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
synonym: "RNA polymerase II transcription co-activator activity" RELATED []
synonym: "RNA polymerase II transcription coactivator activity" RELATED []
synonym: "RNA polymerase II transcription mediator activity" RELATED []
synonym: "transcription co-activator activity" EXACT []
is_a: GO:0003712 ! transcription coregulator activity

[Term]
id: GO:0003714
name: transcription corepressor activity
namespace: molecular_function
alt_id: GO:0001106
def: "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
synonym: "RNA polymerase II transcription co-repressor activity" RELATED []
synonym: "RNA polymerase II transcription corepressor activity" RELATED []
synonym: "transcription co-repressor activity" EXACT []
is_a: GO:0003712 ! transcription coregulator activity

[Term]
id: GO:0003715
name: obsolete transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "transcription termination factor activity" EXACT []
synonym: "transcriptional termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006353

[Term]
id: GO:0003716
name: obsolete RNA polymerase I transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol I transcription termination factor activity" EXACT []
synonym: "RNA polymerase I transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006363

[Term]
id: GO:0003717
name: obsolete RNA polymerase II transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol II transcription termination factor activity" EXACT []
synonym: "RNA polymerase II transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006369

[Term]
id: GO:0003718
name: obsolete RNA polymerase III transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol III transcription termination factor activity" EXACT []
synonym: "RNA polymerase III transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006386

[Term]
id: GO:0003719
name: obsolete transcription factor binding, cytoplasmic sequestering
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process rather than a function.
synonym: "transcription factor binding, cytoplasmic sequestering" EXACT []
is_obsolete: true

[Term]
id: GO:0003720
name: telomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc, PMID:11812242, PMID:28732250]
synonym: "telomerase RNA reverse transcriptase activity" EXACT []
synonym: "telomerase, catalyst" EXACT []
xref: Reactome:R-HSA-163090 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:R-HSA-164617 "Elongation of Extended Telomeric Chromosome End"
is_a: GO:0003964 ! RNA-directed DNA polymerase activity

[Term]
id: GO:0003721
name: obsolete telomerase RNA reverse transcriptase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [PMID:11812242]
comment: This term was obsoleted because it represents the same activity as telomerase activity ; GO:0003720.
synonym: "telomerase, catalyst" EXACT []
is_obsolete: true
replaced_by: GO:0003720

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
alt_id: GO:0000498
alt_id: GO:0044822
def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "base pairing with RNA" NARROW []
synonym: "poly(A) RNA binding" RELATED []
synonym: "poly(A)-RNA binding" RELATED []
synonym: "poly-A RNA binding" RELATED []
xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA"
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003724
name: RNA helicase activity
namespace: molecular_function
alt_id: GO:0004004
def: "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]
synonym: "ATP-dependent RNA helicase activity" EXACT []
xref: EC:3.6.4.13
xref: MetaCyc:RXN-11109
xref: Reactome:R-HSA-72647 "Cap-bound mRNA is activated by helicases"
xref: Reactome:R-HSA-9770129 "Formation of the Spliceosomal A complex"
xref: Reactome:R-HSA-9770131 "Formation of the Spliceosomal B* complex"
xref: Reactome:R-HSA-9770141 "Formation of the Spliceosomal C* complex"
xref: Reactome:R-HSA-9770142 "Formation of the Spliceosomal B complex"
xref: Reactome:R-HSA-9770145 "Formation of the Spliceosomal Bact complex"
is_a: GO:0004386 ! helicase activity
is_a: GO:0008186 ! ATP-dependent activity, acting on RNA
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0003725
name: double-stranded RNA binding
namespace: molecular_function
def: "Binding to double-stranded RNA." [GOC:jl]
synonym: "dsRNA binding" EXACT [GOC:ecd]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003726
name: double-stranded RNA adenosine deaminase activity
namespace: molecular_function
alt_id: GO:0003971
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah, RHEA:10120]
synonym: "double-stranded RNA specific editase activity" RELATED []
xref: EC:3.5.4.37
xref: Reactome:R-HSA-77614 "Deamination at C6 position of adenosine in Editosome (ADAR1)"
xref: Reactome:R-HSA-77615 "Deamination at C6 position of adenosine in Editosome (ADAR2)"
xref: RHEA:10120
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0003727
name: single-stranded RNA binding
namespace: molecular_function
alt_id: GO:0003728
def: "Binding to single-stranded RNA." [GOC:jl]
synonym: "ssRNA binding" EXACT [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003729
name: mRNA binding
namespace: molecular_function
alt_id: GO:0000499
def: "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]
subset: goslim_chembl
subset: goslim_yeast
synonym: "base pairing with mRNA" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003730
name: mRNA 3'-UTR binding
namespace: molecular_function
def: "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]
synonym: "mRNA 3' UTR binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0003731
name: obsolete mRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
synonym: "mRNA cap binding" EXACT []
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003732
name: obsolete snRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
synonym: "snRNA cap binding" EXACT []
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003733
name: obsolete ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "ribonucleoprotein" EXACT []
is_obsolete: true
replaced_by: GO:1990904

[Term]
id: GO:0003734
name: obsolete small nuclear ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "small nuclear ribonucleoprotein" EXACT []
synonym: "snRNP" EXACT []
is_obsolete: true
replaced_by: GO:0030532

[Term]
id: GO:0003735
name: structural constituent of ribosome
namespace: molecular_function
alt_id: GO:0003736
alt_id: GO:0003737
alt_id: GO:0003738
alt_id: GO:0003739
alt_id: GO:0003740
alt_id: GO:0003741
alt_id: GO:0003742
def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "ribosomal protein" BROAD []
synonym: "ribosomal RNA" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0003743
name: translation initiation factor activity
namespace: molecular_function
alt_id: GO:0003744
alt_id: GO:0003745
def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
xref: Reactome:R-HSA-72621 "Ribosomal scanning"
xref: Reactome:R-HSA-72697 "Start codon recognition"
xref: Reactome:R-HSA-72722 "eIF2 activation"
is_a: GO:0008135 ! translation factor activity, RNA binding

[Term]
id: GO:0003746
name: translation elongation factor activity
namespace: molecular_function
alt_id: GO:0008182
alt_id: GO:0008183
def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
xref: Reactome:R-HSA-192704 "Synthesis of PB1-F2"
xref: Reactome:R-HSA-192841 "Viral Protein Synthesis"
is_a: GO:0008135 ! translation factor activity, RNA binding

[Term]
id: GO:0003747
name: translation release factor activity
namespace: molecular_function
alt_id: GO:0003748
alt_id: GO:0003749
def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
is_a: GO:0008079 ! translation termination factor activity

[Term]
id: GO:0003750
name: obsolete cell cycle regulator
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a single molecular function.
synonym: "cell cycle regulator" EXACT []
is_obsolete: true
replaced_by: GO:0051726

[Term]
id: GO:0003754
name: obsolete chaperone activity
namespace: molecular_function
alt_id: GO:0003757
alt_id: GO:0003758
alt_id: GO:0003760
alt_id: GO:0003761
def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684]
comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes.
synonym: "chaperone activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003755
name: peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
alt_id: GO:0004752
alt_id: GO:0042028
def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
synonym: "cis-trans proline isomerase activity" EXACT []
synonym: "cyclophilin activity" RELATED [EC:5.2.1.8]
synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW []
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW []
synonym: "immunophilin" RELATED []
synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah]
synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah]
synonym: "parvulin" RELATED []
synonym: "peptide bond isomerase activity" RELATED [EC:5.2.1.8]
synonym: "peptidyl-prolyl isomerase B reaction" RELATED []
synonym: "peptidylproline cis-trans-isomerase activity" RELATED [EC:5.2.1.8]
synonym: "peptidylprolyl cis-trans isomerase activity" RELATED [EC:5.2.1.8]
synonym: "peptidylprolyl isomerase activity" RELATED [EC:5.2.1.8]
synonym: "PPIase activity" RELATED [EC:5.2.1.8]
synonym: "rotamase activity" RELATED [EC:5.2.1.8]
xref: EC:5.2.1.8
xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
xref: Reactome:R-HSA-2022073 "Procollagen triple helix formation"
xref: Reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1"
xref: RHEA:16237
is_a: GO:0016859 ! cis-trans isomerase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0003756
name: protein disulfide isomerase activity
namespace: molecular_function
alt_id: GO:0006467
def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]
synonym: "disulphide bond formation" EXACT []
synonym: "protein cysteine-thiol oxidation" RELATED []
synonym: "protein disulfide-isomerase" EXACT [EC:5.3.4.1]
synonym: "protein disulphide isomerase activity" EXACT []
synonym: "protein thiol-disulfide exchange" EXACT []
synonym: "protein thiol-disulphide exchange" EXACT []
synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1]
xref: EC:5.3.4.1
xref: MetaCyc:5.3.4.1-RXN
xref: Reactome:R-HSA-8950113 "IL12A binds IL12B"
xref: Reactome:R-HSA-8950183 "IL12B binds IL23A"
xref: Reactome:R-HSA-8950456 "IL12B dimerizes"
is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0003759
name: obsolete glycoprotein-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "glycoprotein-specific chaperone activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003762
name: obsolete histone-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "histone-specific chaperone activity" EXACT []
synonym: "nucleosome assembly chaperone" EXACT []
is_obsolete: true
consider: GO:0006334
consider: GO:0042393

[Term]
id: GO:0003763
name: obsolete chaperonin ATPase activity
namespace: molecular_function
alt_id: GO:0003764
alt_id: GO:0003765
alt_id: GO:0003766
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "chaperonin" EXACT []
synonym: "chaperonin ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016887
consider: GO:0006457

[Term]
id: GO:0003767
name: obsolete co-chaperone activity
namespace: molecular_function
alt_id: GO:0003768
alt_id: GO:0003769
alt_id: GO:0003770
alt_id: GO:0003771
def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
synonym: "co-chaperone activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003772
name: obsolete co-chaperonin activity
namespace: molecular_function
def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
synonym: "co-chaperonin activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003773
name: obsolete heat shock protein activity
namespace: molecular_function
def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
synonym: "heat shock protein activity" EXACT []
is_obsolete: true
consider: GO:0006986
consider: GO:0042026

[Term]
id: GO:0003774
name: cytoskeletal motor activity
namespace: molecular_function
def: "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]
subset: goslim_candida
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "motor activity" BROAD []
xref: Reactome:R-HSA-1861595 "Extension of pseudopodia by myosin-X in a PI3K dependent manner"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0003775
name: obsolete axonemal motor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes cellular component information.
synonym: "axonemal motor activity" EXACT []
is_obsolete: true
consider: GO:0003777
consider: GO:0005930

[Term]
id: GO:0003776
name: obsolete muscle motor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes anatomy information.
synonym: "muscle motor activity" EXACT []
is_obsolete: true
replaced_by: GO:0000146
consider: GO:0006936
consider: GO:0043292

[Term]
id: GO:0003777
name: microtubule motor activity
namespace: molecular_function
alt_id: GO:1990939
def: "A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]
comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'.
synonym: "ATP-dependent microtubule motor activity" EXACT []
synonym: "axonemal motor activity" NARROW []
synonym: "dynein" BROAD []
synonym: "dynein ATPase activity" NARROW []
synonym: "kinesin" BROAD []
synonym: "kinesin motor activity" NARROW []
synonym: "kinetochore motor activity" NARROW []
xref: Reactome:R-HSA-177479 "Axonal transport of NGF:Trk complexes"
xref: Reactome:R-HSA-265160 "Insulin secretory granule translocates to cell cortex"
xref: Reactome:R-HSA-9610627 "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane"
is_a: GO:0003774 ! cytoskeletal motor activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0003778
name: obsolete dynactin motor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex.
synonym: "dynactin motor" EXACT []
is_obsolete: true

[Term]
id: GO:0003779
name: actin binding
namespace: molecular_function
def: "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
synonym: "membrane associated actin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0003780
name: obsolete actin cross-linking activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid]
comment: This term was made obsolete because it represents a combination of molecular functions.
synonym: "actin cross-linking activity" EXACT []
is_obsolete: true
consider: GO:0030674
consider: GO:0051015

[Term]
id: GO:0003781
name: obsolete actin bundling activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "actin bundling activity" EXACT []
is_obsolete: true
replaced_by: GO:0051017

[Term]
id: GO:0003782
name: obsolete F-actin capping activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
synonym: "F-actin capping activity" EXACT []
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003783
name: obsolete barbed-end actin capping activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
synonym: "barbed-end actin capping activity" EXACT []
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003784
name: obsolete barbed-end actin capping/severing activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes two biological processes.
synonym: "barbed-end actin capping/severing activity" EXACT []
is_obsolete: true
consider: GO:0051014
consider: GO:0051016

[Term]
id: GO:0003785
name: actin monomer binding
namespace: molecular_function
def: "Binding to monomeric actin, also known as G-actin." [GOC:ai]
synonym: "G actin binding" EXACT []
is_a: GO:0003779 ! actin binding

[Term]
id: GO:0003786
name: actin lateral binding
namespace: molecular_function
def: "Binding to an actin filament along its length." [GOC:mah]
is_a: GO:0051015 ! actin filament binding

[Term]
id: GO:0003787
name: obsolete actin depolymerizing activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "actin depolymerizing activity" EXACT []
is_obsolete: true
replaced_by: GO:0030042

[Term]
id: GO:0003788
name: obsolete actin monomer sequestering activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process, not an activity.
synonym: "actin monomer sequestering activity" EXACT []
is_obsolete: true

[Term]
id: GO:0003789
name: actin filament severing activity
namespace: molecular_function
def: "Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments." [PMID:11812157, PMID:23395798, PMID:23727096]
synonym: "actin depolymerizing activity" EXACT []
is_a: GO:0140776 ! protein-containing complex destabilizing activity

[Term]
id: GO:0003790
name: obsolete actin modulating activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not make sense.
synonym: "actin modulating activity" EXACT []
is_obsolete: true
consider: GO:0030036

[Term]
id: GO:0003791
name: obsolete membrane associated actin binding
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "membrane associated actin binding" EXACT []
is_obsolete: true
consider: GO:0003779
consider: GO:0016020

[Term]
id: GO:0003792
name: obsolete regulation of actin thin filament length activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the term belongs in the process ontology.
synonym: "regulation of actin thin filament length activity" EXACT []
is_obsolete: true
replaced_by: GO:0030832

[Term]
id: GO:0003793
name: obsolete defense/immunity protein activity
namespace: molecular_function
def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "defence/immunity protein activity" EXACT []
synonym: "defense/immunity protein activity" EXACT []
is_obsolete: true
consider: GO:0006952

[Term]
id: GO:0003794
name: obsolete acute-phase response protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "acute-phase response protein activity" EXACT []
is_obsolete: true
consider: GO:0006953

[Term]
id: GO:0003795
name: obsolete antimicrobial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "antimicrobial peptide activity" EXACT []
is_obsolete: true
consider: GO:0019730

[Term]
id: GO:0003796
name: lysozyme activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813]
synonym: "1,4-N-acetylmuramidase activity" EXACT []
synonym: "globulin G" RELATED [EC:3.2.1.17]
synonym: "globulin G1" RELATED [EC:3.2.1.17]
synonym: "L-7001" RELATED [EC:3.2.1.17]
synonym: "lysozyme g" RELATED [EC:3.2.1.17]
synonym: "mucopeptide glucohydrolase activity" EXACT []
synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT []
synonym: "muramidase activity" EXACT []
synonym: "N,O-diacetylmuramidase activity" EXACT []
synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" RELATED [EC:3.2.1.17]
synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17]
xref: EC:3.2.1.17
xref: MetaCyc:3.2.1.17-RXN
xref: Reactome:R-HSA-8862320 "LYZ hydrolyzes peptidoglycans in the bacterial cell wall"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0061783 ! peptidoglycan muralytic activity

[Term]
id: GO:0003797
name: obsolete antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0042742

[Term]
id: GO:0003798
name: obsolete male-specific antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "male-specific antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0050831

[Term]
id: GO:0003799
name: obsolete antifungal peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "antifungal peptide activity" EXACT []
is_obsolete: true
consider: GO:0050832

[Term]
id: GO:0003800
name: obsolete antiviral response protein activity
namespace: molecular_function
def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "antiviral response protein activity" EXACT []
is_obsolete: true
consider: GO:0009615

[Term]
id: GO:0003801
name: obsolete blood coagulation factor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "blood coagulation factor activity" EXACT []
is_obsolete: true
consider: GO:0004252
consider: GO:0007596

[Term]
id: GO:0003802
name: obsolete coagulation factor VIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [PMID:12496253]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor VII" RELATED []
synonym: "blood coagulation factor VII activity" EXACT []
synonym: "blood-coagulation factor VIIa" RELATED []
synonym: "coagulation factor VIIa activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003803
name: obsolete coagulation factor IXa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XI" RELATED []
synonym: "activated blood-coagulation factor IX" RELATED []
synonym: "activated christmas factor" RELATED []
synonym: "autoprothrombin II" RELATED []
synonym: "blood coagulation factor IX activity" EXACT []
synonym: "blood platelet cofactor II" RELATED []
synonym: "blood-coagulation factor IXa" RELATED []
synonym: "Christmas factor activity" RELATED []
synonym: "coagulation factor IXa activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003804
name: obsolete coagulation factor Xa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [GOC:jl, PMID:7354023]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor X" RELATED []
synonym: "activated factor X" RELATED []
synonym: "activated Stuart-Prower factor" RELATED []
synonym: "autoprothrombin C" RELATED []
synonym: "blood coagulation factor X activity" EXACT []
synonym: "coagulation factor Xa activity" EXACT []
synonym: "factor Xa" RELATED []
synonym: "plasma thromboplastin" RELATED []
synonym: "prothrombase activity" RELATED []
synonym: "prothrombinase activity" RELATED []
synonym: "Stuart factor" RELATED []
synonym: "Stuart factor activity" RELATED []
synonym: "thrombokinase activity" RELATED []
synonym: "thromboplastin" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003805
name: obsolete coagulation factor XIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor XI" RELATED []
synonym: "activated plasma thromboplastin antecedent" RELATED []
synonym: "blood coagulation factor XI activity" EXACT []
synonym: "blood-coagulation factor XIa" RELATED []
synonym: "coagulation factor XIa activity" EXACT []
synonym: "plasma thromboplastin antecedent activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003806
name: obsolete coagulation factor XIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated beta blood-coagulation factor XII" RELATED []
synonym: "blood coagulation factor XII activity" EXACT []
synonym: "blood-coagulation factor XIIabeta" RELATED []
synonym: "blood-coagulation factor XIIf" RELATED []
synonym: "coagulation factor XIIa activity" EXACT []
synonym: "hageman factor (activated)" RELATED []
synonym: "hageman factor activity" RELATED []
synonym: "hageman factor beta-fragment" RELATED []
synonym: "hageman factor fragment HFf" RELATED []
synonym: "kallikreinogen activator" RELATED []
synonym: "prealbumin activator" RELATED []
synonym: "prekallikrein activator" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003807
name: obsolete plasma kallikrein activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "callicrein" RELATED []
synonym: "depot-padutin" RELATED []
synonym: "dilminal D" RELATED []
synonym: "glumorin" RELATED []
synonym: "kallidinogenase" BROAD []
synonym: "kallikrein" RELATED []
synonym: "kallikrein I" RELATED []
synonym: "kallikrein II" RELATED []
synonym: "kininogenase" BROAD []
synonym: "kininogenin activity" RELATED []
synonym: "onokrein P" RELATED []
synonym: "padreatin" RELATED []
synonym: "padutin" RELATED []
synonym: "panceatic kallikrein" RELATED []
synonym: "plasma kallikrein activity" EXACT []
synonym: "serum kallikrein activity" RELATED []
synonym: "urinary kallikrein" RELATED []
synonym: "urokallikrein" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003808
name: obsolete protein C (activated) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XIV activity" RELATED []
synonym: "activated protein C" RELATED []
synonym: "autoprothrombin II-A" RELATED []
synonym: "autoprothrombin IIA activity" RELATED []
synonym: "blood-coagulation factor XIVa" RELATED []
synonym: "GSAPC" RELATED []
synonym: "protein C (activated) activity" EXACT []
synonym: "protein Ca" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003809
name: obsolete thrombin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor II" RELATED []
synonym: "beta-thrombin" RELATED []
synonym: "blood-coagulation factor IIa" RELATED []
synonym: "E thrombin" RELATED []
synonym: "factor IIa" RELATED []
synonym: "fibrinogenase activity" RELATED []
synonym: "gamma-thrombin" RELATED []
synonym: "thrombase activity" RELATED []
synonym: "thrombin activity" EXACT []
synonym: "thrombin-C" RELATED []
synonym: "thrombofort" RELATED []
synonym: "topical" RELATED []
synonym: "tropostasin" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003810
name: protein-glutamine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13]
synonym: "factor XIIIa" RELATED [EC:2.3.2.13]
synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13]
synonym: "fibrinoligase activity" EXACT []
synonym: "glutaminylpeptide gamma-glutamyltransferase activity" RELATED [EC:2.3.2.13]
synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13]
synonym: "protein-glutamine:amine gamma-glutamyltransferase" RELATED [EC:2.3.2.13]
synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" RELATED [EC:2.3.2.13]
synonym: "TGase activity" EXACT []
synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13]
synonym: "transglutaminase activity" EXACT []
xref: EC:2.3.2.13
xref: MetaCyc:2.3.2.13-RXN
xref: Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+"
xref: Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking"
xref: RESID:AA0124
xref: RHEA:54816
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0003811
name: obsolete complement activity
namespace: molecular_function
def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "complement activity" EXACT []
is_obsolete: true
consider: GO:0006956

[Term]
id: GO:0003812
name: obsolete alternative-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "(C3b)n,Bb" RELATED []
synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED []
synonym: "alternative complement pathway C3(C5) convertase activity" RELATED []
synonym: "alternative-complement-pathway C3/C5 convertase activity" EXACT []
synonym: "C3 convertase activity" BROAD []
synonym: "C3 proactivator" RELATED []
synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" RELATED []
synonym: "C5 convertase activity" BROAD []
synonym: "cobra venom factor-dependent C3 convertase" NARROW []
synonym: "complement C 3(C 5) convertase (amplification)" RELATED []
synonym: "complement component C3/C5 convertase (alternative) activity" RELATED []
synonym: "complement factor B activity" RELATED []
synonym: "CVF,Bb" RELATED []
synonym: "glycine-rich beta-glycoprotein" RELATED []
synonym: "heat-labile factor" RELATED []
synonym: "proenzyme factor B" EXACT []
synonym: "properdin factor B activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003813
name: obsolete classical-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3 convertase activity" BROAD []
synonym: "C42" RELATED []
synonym: "C423" RELATED []
synonym: "C4b,2a" RELATED []
synonym: "C4b,2a,3b" RELATED []
synonym: "C5 convertase activity" BROAD []
synonym: "classical-complement-pathway C3/C5 convertase activity" EXACT []
synonym: "complement C2 activity" BROAD []
synonym: "complement C3 convertase activity" RELATED []
synonym: "complement C42" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003815
name: obsolete complement component C1r activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1r" RELATED []
synonym: "C1r esterase activity" RELATED []
synonym: "complement component C1r activity" EXACT []
synonym: "complement subcomponent C1r" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003816
name: obsolete complement component C1s activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1s" RELATED []
synonym: "C1 esterase activity" RELATED []
synonym: "C1s esterase activity" RELATED []
synonym: "complement C1s" RELATED []
synonym: "complement component C1s activity" EXACT []
synonym: "complement subcomponent C1s" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003817
name: obsolete complement factor D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "adipsin" EXACT []
synonym: "C3 convertase activator activity" RELATED []
synonym: "C3 proactivator convertase activity" RELATED []
synonym: "complement factor D activity" EXACT []
synonym: "factor D" RELATED []
synonym: "factor D (complement)" RELATED []
synonym: "properdin factor D esterase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003818
name: obsolete complement factor I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3b inactivator activity" NARROW []
synonym: "C3b/C4b inactivator activity" RELATED []
synonym: "C3bINA" RELATED []
synonym: "complement C3b inactivator" RELATED []
synonym: "complement C3b/C4b inactivator" RELATED []
synonym: "complement C4b inactivator" RELATED []
synonym: "complement C4bi" RELATED []
synonym: "complement component C3b inactivator activity" RELATED []
synonym: "complement factor I activity" EXACT []
synonym: "conglutinogen-activating factor C" RELATED []
synonym: "factor I" RELATED [EC:3.4.21.45]
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003819
name: obsolete major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "major histocompatibility complex antigen" EXACT []
synonym: "MHC protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003820
name: obsolete class I major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "class I major histocompatibility complex antigen" EXACT []
is_obsolete: true
consider: GO:0042612

[Term]
id: GO:0003821
name: obsolete class II major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "class II major histocompatibility complex antigen" EXACT []
is_obsolete: true
consider: GO:0042613

[Term]
id: GO:0003822
name: obsolete MHC-interacting protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "MHC-interacting protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003823
name: antigen binding
namespace: molecular_function
def: "Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell." [GOC:jl, ISBN:0198506732, ISBN:0721662544]
subset: goslim_chembl
subset: goslim_pir
synonym: "antibody activity" RELATED []
synonym: "B cell receptor activity" NARROW []
synonym: "major histocompatibility complex activity" NARROW []
synonym: "major histocompatibility complex antigen display activity" NARROW []
synonym: "MHC activity" NARROW []
synonym: "opsonin activity" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003824
name: catalytic activity
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Enzyme
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0003825
name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15]
synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" RELATED [EC:2.4.1.15]
synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" RELATED [EC:2.4.1.15]
synonym: "transglucosylase activity" EXACT []
synonym: "trehalose 6-phosphate synthase activity" EXACT []
synonym: "trehalose 6-phosphate synthetase activity" EXACT []
synonym: "trehalose phosphate synthase activity" RELATED [EC:2.4.1.15]
synonym: "trehalose phosphate synthetase activity" RELATED [EC:2.4.1.15]
synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.15]
synonym: "trehalose-P synthetase activity" RELATED [EC:2.4.1.15]
synonym: "trehalose-phosphate synthase activity" EXACT []
synonym: "trehalose-phosphate synthetase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" RELATED [EC:2.4.1.15]
synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT []
synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.15]
synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.15]
synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" RELATED [EC:2.4.1.15]
xref: EC:2.4.1.15
xref: MetaCyc:TREHALOSE6PSYN-RXN
xref: RHEA:18889
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003827
name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP." [EC:2.4.1.101, RHEA:11456]
synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.101]
synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.101]
synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "GnTI" RELATED [EC:2.4.1.101]
synonym: "GNTI activity" RELATED [EC:2.4.1.101]
synonym: "N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101]
synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101]
synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.101]
xref: EC:2.4.1.101
xref: KEGG_REACTION:R05983
xref: MetaCyc:2.4.1.101-RXN
xref: Reactome:R-HSA-964768 "Addition of GlcNAc to the glycan on the A arm"
xref: RHEA:11456
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0003828
name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.3.8]
synonym: "alpha-2,8-sialyltransferase activity" RELATED [EC:2.4.3.8]
synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT []
synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.3.8]
synonym: "ganglioside GD3 synthase activity" RELATED [EC:2.4.3.8]
synonym: "ganglioside GD3 synthetase sialyltransferase activity" RELATED [EC:2.4.3.8]
xref: EC:2.4.3.8
xref: MetaCyc:2.4.99.8-RXN
xref: Reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans"
xref: Reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues"
xref: Reactome:R-HSA-422454 "Polysialylation of NCAM1"
xref: Reactome:R-HSA-9845587 "ST8SIA5 transfers Neu5Ac to gangliosides"
xref: RHEA:19313
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003829
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. This reaction is the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2." [EC:2.4.1.102]
synonym: "beta(6)-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.102]
synonym: "beta6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.102]
synonym: "core 2 acetylglucosaminyltransferase activity" RELATED []
synonym: "core 6-beta-GlcNAc-transferase A" RELATED []
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.102]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" RELATED []
synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity" RELATED []
synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" RELATED []
xref: EC:2.4.1.102
xref: MetaCyc:2.4.1.102-RXN
xref: Reactome:R-HSA-914012 "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins"
xref: Reactome:R-HSA-914018 "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein"
xref: RHEA:18705
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0003830
name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144]
synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.144]
synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.144]
synonym: "GnTIII activity" RELATED [EC:2.4.1.144]
synonym: "N-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.144]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.144]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144]
xref: EC:2.4.1.144
xref: MetaCyc:2.4.1.144-RXN
xref: Reactome:R-HSA-975926 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3"
xref: RHEA:15509
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0003831
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38]
synonym: "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "beta-N-acetyl-beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "GalT activity" RELATED [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyl-transferase activity" RELATED [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "glycoprotein beta-galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38]
synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38]
synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.38]
synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" RELATED [EC:2.4.1.38]
xref: EC:2.4.1.38
xref: MetaCyc:2.4.1.38-RXN
xref: Reactome:R-HSA-1912352 "Galactosylation of Pre-NOTCH"
xref: Reactome:R-HSA-2025723 "B4GALTs transfer Gal to the N-glycan precursor"
xref: Reactome:R-HSA-2046265 "B4GALTs transfer Gal to the keratan chain"
xref: Reactome:R-HSA-2046298 "B4GALTs transfer Gal to a branch of keratan"
xref: Reactome:R-HSA-3656230 "Defective B4GALT1 does not transfer Gal to the keratan chain"
xref: Reactome:R-HSA-4793956 "Defective B4GALT1 does not add Gal to N-glycan"
xref: Reactome:R-HSA-9035949 "Defective B4GALT1 does not transfer Gal to the N-glycan precursor"
xref: Reactome:R-HSA-9035950 "Defective B4GALT1 does not transfer Gal to a branch of keratan"
xref: Reactome:R-HSA-975919 "Addition of galactose by beta 4-galactosyltransferases"
xref: RHEA:22932
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003832
name: beta-alanyl-dopamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543]
synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT []
synonym: "NBAD hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0003833
name: beta-alanyl amine synthase activity
namespace: molecular_function
def: "Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine." [GOC:bf, ISBN:0198506732, PMID:12900414, PMID:12957543, PMID:25229196]
synonym: "beta-alanyl-dopamine synthase activity" RELATED []
synonym: "N-beta-alanyl dopamine synthetase activity" EXACT []
synonym: "NBAD transferase activity" EXACT []
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0003834
name: beta-carotene 15,15'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal." [RHEA:32887]
synonym: "beta-carotene 15,15'-monooxygenase activity" RELATED []
synonym: "carotene 15,15'-dioxygenase activity" RELATED [EC:1.13.11.63]
synonym: "carotene dioxygenase activity" RELATED [EC:1.13.11.63]
xref: EC:1.13.11.63
xref: KEGG_REACTION:R00032
xref: MetaCyc:RXN-13374
xref: Reactome:R-HSA-975635 "BCMO1:Fe2+ cleaves betaC to atRAL"
xref: RHEA:32887
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0003835
name: beta-galactoside alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+." [EC:2.4.3.1]
synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.3.1]
synonym: "beta-galactoside alpha-(2,6)-sialyltransferase" EXACT [EC:2.4.3.1]
synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.3.1]
synonym: "lactosylceramide alpha-2,6-N-sialyltransferase" RELATED [EC:2.4.3.1]
xref: EC:2.4.3.1
xref: MetaCyc:RXN-18268
xref: Reactome:R-HSA-4085033 "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)"
xref: Reactome:R-HSA-975902 "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans"
xref: Reactome:R-HSA-977071 "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens"
xref: RHEA:52104
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003836
name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.3.4]
xref: EC:2.4.3.4
xref: MetaCyc:2.4.99.4-RXN
xref: Reactome:R-HSA-1022129 "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans"
xref: Reactome:R-HSA-1912378 "Sialylation of Pre-NOTCH"
xref: Reactome:R-HSA-2046285 "The keratan chain can be capped by N-acetylneuraminic acid"
xref: Reactome:R-HSA-3656258 "Defective ST3GAL3 does not transfer SA to keratan"
xref: Reactome:R-HSA-4084984 "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)"
xref: Reactome:R-HSA-9603987 "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG"
xref: Reactome:R-HSA-9605600 "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG"
xref: Reactome:R-HSA-981497 "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position"
xref: Reactome:R-HSA-9844860 "ST3GAL5 transfers NeuNAc to ceramides"
xref: Reactome:R-HSA-9845538 "ST3GAL2,3 transfer Neu5Ac to gangliosides"
xref: RHEA:21616
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003837
name: beta-ureidopropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" RELATED [EC:3.5.1.6]
xref: EC:3.5.1.6
xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN
xref: Reactome:R-HSA-73591 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2"
xref: Reactome:R-HSA-73620 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2"
xref: RHEA:11184
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0003838
name: sterol 24-C-methyltransferase activity
namespace: molecular_function
alt_id: GO:0102101
def: "Catalysis of the reaction: S-adenosyl-L-methionine + zymosterol = fecosterol + H+ + S-adenosyl-L-homocysteine." [RHEA:21128]
synonym: "24-sterol C-methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "delta(24)-methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "delta(24)-sterol C-methyltransferase activity" EXACT []
synonym: "delta(24)-sterol methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "delta24-methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "delta24-sterol methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" RELATED [EC:2.1.1.41]
synonym: "SMT1 activity" NARROW [EC:2.1.1.41]
synonym: "sterol 24C methyltransferase activity" EXACT []
synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41]
xref: EC:2.1.1.41
xref: MetaCyc:RXN3O-178
xref: RHEA:21128
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0003839
name: gamma-glutamylcyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [PMID:18515354]
synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT []
synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT []
synonym: "gamma-L-glutamylcyclotransferase activity" EXACT []
synonym: "L-glutamic cyclase activity" EXACT []
xref: EC:4.3.2.9
xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
xref: Reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO"
xref: Reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly"
xref: RHEA:20505
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0003840
name: obsolete gamma-glutamyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [GOC:curators]
comment: This term was obsoleted because it does not correspond to a physiological reaction.\nUsage comment: The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity).
is_obsolete: true
consider: GO:0036374

[Term]
id: GO:0003841
name: 1-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0004469
def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab]
synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" RELATED [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "1-acylglycero-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.51]
synonym: "1-acylglycerolphosphate acyltransferase activity" RELATED [EC:2.3.1.51]
synonym: "1-acylglycerophosphate acyltransferase activity" RELATED [EC:2.3.1.51]
synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" RELATED [EC:2.3.1.51]
synonym: "lysophosphatidate acyltransferase activity" EXACT []
synonym: "lysophosphatidic acid-acyltransferase activity" RELATED [EC:2.3.1.51]
xref: EC:2.3.1.51
xref: MetaCyc:RXN-1623
xref: Reactome:R-HSA-1482539 "1-acyl LPG is acylated to PG by LPGAT"
xref: Reactome:R-HSA-1482547 "1-acyl LPC is acylated to PC by LPCAT"
xref: Reactome:R-HSA-1482548 "1-acyl LPA is acylated to PA by AGPAT5 (OM)"
xref: Reactome:R-HSA-1482598 "1-acyl LPI is acylated to PI by MBOAT7"
xref: Reactome:R-HSA-1482636 "1-acyl LPS is acylated to PS by LPSAT"
xref: Reactome:R-HSA-1482667 "1-acyl LPE is acylated to PE by LPEAT"
xref: Reactome:R-HSA-1482689 "1-acyl LPG is acylated to PG by CRLS1 (IM)"
xref: Reactome:R-HSA-1482894 "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)"
xref: Reactome:R-HSA-75885 "1-acyl LPA is acylated to PA by AGPAT (LPAAT)"
xref: Reactome:R-HSA-8849345 "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine"
xref: RHEA:19709
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity
is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity

[Term]
id: GO:0003842
name: 1-pyrroline-5-carboxylate dehydrogenase activity
namespace: molecular_function
def: "H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH." [RHEA:30235]
synonym: "1-pyrroline dehydrogenase" BROAD []
synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" RELATED []
synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" RELATED [EC:1.2.1.88]
synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" RELATED []
synonym: "pyrroline-5-carboxylate dehydrogenase activity" RELATED [EC:1.2.1.88]
synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" RELATED [EC:1.2.1.88]
xref: EC:1.2.1.88
xref: MetaCyc:RXN-14116
xref: Reactome:R-HSA-6784399 "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate"
xref: Reactome:R-HSA-70679 "ALDH4A1 oxidises L-GluSS to Glu"
xref: RHEA:30235
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003843
name: 1,3-beta-D-glucan synthase activity
namespace: molecular_function
alt_id: GO:0009981
def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34]
synonym: "(1,3)-beta-glucan (callose) synthase activity" RELATED [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan synthetase activity" RELATED [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "1,3-beta-glucan synthase activity" RELATED [EC:2.4.1.34]
synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "beta-1,3-glucan synthase activity" EXACT []
synonym: "beta-1,3-glucan synthetase activity" RELATED [EC:2.4.1.34]
synonym: "callose synthase activity" EXACT []
synonym: "callose synthetase activity" RELATED [EC:2.4.1.34]
synonym: "GS-II" RELATED [EC:2.4.1.34]
synonym: "paramylon synthetase" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.34]
synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34]
xref: EC:2.4.1.34
xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN
xref: RHEA:21476
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003844
name: 1,4-alpha-glucan branching enzyme activity
namespace: molecular_function
def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18]
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT []
synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT []
synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" RELATED [EC:2.4.1.18]
synonym: "alpha-glucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.18]
synonym: "amylo-(1,4 to 1,6)transglucosidase activity" RELATED [EC:2.4.1.18]
synonym: "amylo-(1,4->1,6)-transglycosylase activity" RELATED [EC:2.4.1.18]
synonym: "amylose isomerase activity" RELATED [EC:2.4.1.18]
synonym: "branching enzyme activity" RELATED [EC:2.4.1.18]
synonym: "branching glycosyltransferase activity" RELATED [EC:2.4.1.18]
synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18]
synonym: "enzyme Q" RELATED [EC:2.4.1.18]
synonym: "glucosan transglycosylase activity" RELATED [EC:2.4.1.18]
synonym: "glycogen branching enzyme activity" RELATED [EC:2.4.1.18]
synonym: "plant branching enzyme" RELATED [EC:2.4.1.18]
synonym: "Q-enzyme" RELATED [EC:2.4.1.18]
synonym: "starch branching enzyme" RELATED [EC:2.4.1.18]
xref: EC:2.4.1.18
xref: MetaCyc:GLYCOGEN-BRANCH-RXN
xref: Reactome:R-HSA-3322005 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a"
xref: Reactome:R-HSA-3322016 "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a"
xref: Reactome:R-HSA-3322057 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b"
xref: Reactome:R-HSA-3878762 "Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)"
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0003845
name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+." [PMID:15761036]
subset: gocheck_do_not_annotate
synonym: "11beta-hydroxy steroid dehydrogenase" RELATED []
synonym: "11beta-hydroxysteroid dehydrogenase" RELATED []
synonym: "beta-hydroxysteroid dehydrogenase" BROAD []
synonym: "corticosteroid 11-reductase" RELATED []
synonym: "corticosteroid 11beta-dehydrogenase" RELATED []
xref: Reactome:R-HSA-194023 "HSD11B2,HSD11B1 dimer oxidise CORT to COR"
xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003846
name: 2-acylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [PMID:4016575, RHEA:16741]
synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" RELATED [EC:2.3.1.22]
synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" RELATED [EC:2.3.1.22]
synonym: "acylglycerol palmitoyltransferase activity" RELATED [EC:2.3.1.22]
synonym: "monoacylglycerol acyltransferase activity" RELATED [EC:2.3.1.22]
synonym: "monoglyceride acyltransferase activity" RELATED [EC:2.3.1.22]
xref: EC:2.3.1.22
xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
xref: Reactome:R-HSA-5696448 "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG"
xref: Reactome:R-HSA-6800334 "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG"
xref: RHEA:16741
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0003847
name: 1-alkyl-2-acetylglycerophosphocholine esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+." [RHEA:17777]
subset: goslim_chembl
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" RELATED [EC:3.1.1.47]
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT []
synonym: "alkylacetyl-GPC:acetylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA2" RELATED [EC:3.1.1.47]
synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47]
xref: EC:3.1.1.47
xref: MetaCyc:3.1.1.47-RXN
xref: Reactome:R-HSA-8869206 "PAFAH2 hydrolyses PAF to lyso-PAF and acetate"
xref: RHEA:17777
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0003848
name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+." [EC:2.7.6.3, RHEA:11412]
subset: goslim_chembl
synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT []
synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" RELATED [EC:2.7.6.3]
synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" RELATED [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" RELATED [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" RELATED [EC:2.7.6.3]
synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" RELATED [EC:2.7.6.3]
synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" RELATED [EC:2.7.6.3]
synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" RELATED [EC:2.7.6.3]
synonym: "HPPK" RELATED [EC:2.7.6.3]
synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" RELATED [EC:2.7.6.3]
xref: EC:2.7.6.3
xref: KEGG_REACTION:R03503
xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
xref: RHEA:11412
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0003849
name: 3-deoxy-7-phosphoheptulonate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14717]
synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" RELATED [EC:2.5.1.54]
synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" RELATED [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" RELATED [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" RELATED [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" RELATED [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.54]
synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54]
synonym: "DAH7-P synthase activity" RELATED [EC:2.5.1.54]
synonym: "DAHP synthase activity" RELATED [EC:2.5.1.54]
synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" RELATED [EC:2.5.1.54]
synonym: "DHAP synthase activity" RELATED [EC:2.5.1.54]
synonym: "DS-Co activity" RELATED [EC:2.5.1.54]
synonym: "DS-Mn activity" RELATED [EC:2.5.1.54]
synonym: "KDPH synthase activity" RELATED [EC:2.5.1.54]
synonym: "KDPH synthetase activity" RELATED [EC:2.5.1.54]
synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" RELATED [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" RELATED [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" RELATED [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" RELATED [EC:2.5.1.54]
synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" RELATED [EC:2.5.1.54]
synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" RELATED [EC:2.5.1.54]
xref: EC:2.5.1.54
xref: KEGG_REACTION:R01826
xref: MetaCyc:DAHPSYN-RXN
xref: RHEA:14717
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003850
name: 2-deoxyglucose-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68]
synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.68]
synonym: "2-deoxyglucose-6-phosphate phosphatase activity" RELATED [EC:3.1.3.68]
xref: EC:3.1.3.68
xref: KEGG_REACTION:R02587
xref: MetaCyc:3.1.3.68-RXN
xref: RHEA:22236
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0003851
name: N-acylsphingosine galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H+ + UDP." [EC:2.4.1.47]
synonym: "2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity" EXACT [EC:2.4.1.47]
xref: EC:2.4.1.47
xref: MetaCyc:2.4.1.47-RXN
xref: Reactome:R-HSA-6785933 "UGT8 transfers Gal from UDP-Gal to CERA"
xref: RHEA:13093
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003852
name: 2-isopropylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+." [RHEA:21524]
synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" RELATED [EC:2.3.3.13]
synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.13]
synonym: "alpha-IPM synthetase activity" RELATED [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthase activity" RELATED [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthetase activity" RELATED [EC:2.3.3.13]
synonym: "alpha-isopropylmalic synthetase activity" RELATED [EC:2.3.3.13]
synonym: "isopropylmalate synthase activity" RELATED [EC:2.3.3.13]
synonym: "isopropylmalate synthetase activity" RELATED [EC:2.3.3.13]
xref: EC:2.3.3.13
xref: KEGG_REACTION:R01213
xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN
xref: RHEA:21524
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0003853
name: short-chain 2-methyl fatty acyl-CoA dehydrogenase activity
namespace: molecular_function
alt_id: GO:0047119
def: "Catalysis of the reaction: Catalysis of the reaction: a short-chain 2-methyl fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-2-methyl-2-enoyl-CoA + reduced [electron-transfer flavoprotein]." [PMID:10989435, PMID:6401712]
synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.8.5]
synonym: "2-methyl-branched-chain-enoyl-CoA reductase activity" RELATED []
synonym: "2-methylacyl-CoA dehydrogenase activity" NARROW []
synonym: "2-methylbutanoyl-CoA dehydrogenase activity" NARROW []
synonym: "2-methylpropanoyl-CoA dehydrogenase activity" NARROW []
synonym: "branched-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.8.5]
synonym: "isobutyryl-CoA:FAD oxidoreductase activity" NARROW []
xref: EC:1.3.8.5
xref: KEGG_REACTION:R03169
is_a: GO:0016937 ! short-chain fatty acyl-CoA dehydrogenase activity

[Term]
id: GO:0003854
name: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxy-Delta(5)-steroid + NAD+ = a 3-oxo-Delta(5)-steroid + NADH + H+. Also acts on on 3-beta-hydroxypregn-5-en-20-one to form progesterone." [EC:1.1.1.145]
synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED [EC:1.1.1.145]
synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT []
synonym: "3beta-HSDH" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.145]
synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.145]
synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.145]
synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145]
synonym: "steroid-delta5-3beta-ol dehydrogenase activity" RELATED [EC:1.1.1.145]
xref: EC:1.1.1.145
xref: MetaCyc:1.1.1.145-RXN
xref: Reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one"
xref: Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one"
xref: Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one"
xref: Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione"
xref: Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003855
name: 3-dehydroquinate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O." [EC:4.2.1.10, RHEA:21096]
synonym: "3-dehydroquinase activity" RELATED [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" RELATED [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase activity" RELATED [EC:4.2.1.10]
synonym: "3-dehydroquinate hydrolase activity" RELATED [EC:4.2.1.10]
synonym: "5-dehydroquinase activity" RELATED [EC:4.2.1.10]
synonym: "5-dehydroquinate dehydratase activity" RELATED [EC:4.2.1.10]
synonym: "5-dehydroquinate hydro-lyase activity" RELATED [EC:4.2.1.10]
synonym: "dehydroquinase activity" RELATED [EC:4.2.1.10]
synonym: "dehydroquinate dehydratase activity" RELATED [EC:4.2.1.10]
synonym: "DHQase" RELATED [EC:4.2.1.10]
xref: EC:4.2.1.10
xref: KEGG_REACTION:R03084
xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN
xref: RHEA:21096
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003856
name: 3-dehydroquinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21968]
xref: EC:4.2.3.4
xref: KEGG_REACTION:R03083
xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN
xref: RHEA:21968
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0003857
name: 3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35]
comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'.
synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079]
synonym: "beta-hydroxyacyl dehydrogenase activity" RELATED [EC:1.1.1.35]
synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" RELATED [EC:1.1.1.35]
synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" RELATED [EC:1.1.1.35]
synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35]
synonym: "beta-keto-reductase activity" RELATED [EC:1.1.1.35]
synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" RELATED [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.35]
xref: EC:1.1.1.35
xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN
xref: Reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA"
xref: Reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA"
xref: Reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+"
xref: Reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA"
xref: Reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+"
xref: Reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA"
xref: Reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+"
xref: Reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H"
xref: Reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H"
xref: Reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H"
xref: Reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H"
xref: Reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H"
xref: Reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H"
xref: Reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H"
xref: RHEA:22432
xref: UM-BBD_reactionID:r1063
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003858
name: 3-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH." [EC:1.1.1.30, RHEA:20521]
synonym: "D-beta-hydroxybutyrate dehydrogenase activity" RELATED [EC:1.1.1.30]
xref: EC:1.1.1.30
xref: KEGG_REACTION:R01361
xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-5696457 "BDH2 dehydrogenates 3HBA"
xref: Reactome:R-HSA-73912 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+"
xref: Reactome:R-HSA-73920 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+"
xref: RHEA:20521
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003859
name: obsolete (3R)-3-hydroxybutyryl-CoA dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O." [EC:4.2.1.55, RHEA:17849]
comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" RELATED [EC:4.2.1.55]
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.55]
synonym: "3-hydroxybutyryl-CoA dehydratase activity" BROAD []
synonym: "crotonase activity" RELATED [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" RELATED [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" RELATED [EC:4.2.1.55]
synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55]
is_obsolete: true
replaced_by: GO:0018812

[Term]
id: GO:0003860
name: 3-hydroxyisobutyryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4]
synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" RELATED [EC:3.1.2.4]
synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" RELATED [EC:3.1.2.4]
synonym: "HIB CoA deacylase activity" RELATED [EC:3.1.2.4]
xref: EC:3.1.2.4
xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN
xref: Reactome:R-HSA-70881 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA"
xref: Reactome:R-HSA-9916727 "HIBCH mutants don't synthesize beta-hydroxyisobutyrate"
xref: RHEA:20888
is_a: GO:0141126 ! short-chain fatty acyl-CoA hydrolase activity

[Term]
id: GO:0003861
name: 3-isopropylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate." [EC:4.2.1.33]
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" RELATED [EC:4.2.1.33]
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" RELATED [EC:4.2.1.33]
synonym: "alpha-IPM isomerase activity" RELATED [EC:4.2.1.33]
synonym: "alpha-isopropylmalate isomerase activity" RELATED [EC:4.2.1.33]
synonym: "beta-isopropylmalate dehydratase activity" RELATED [EC:4.2.1.33]
synonym: "isopropylmalate isomerase activity" RELATED [EC:4.2.1.33]
xref: EC:4.2.1.33
xref: MetaCyc:3-ISOPROPYLMALISOM-RXN
xref: RHEA:32287
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003862
name: 3-isopropylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85, RHEA:32271]
synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.85]
synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.85]
synonym: "beta-IPM dehydrogenase activity" RELATED [EC:1.1.1.85]
synonym: "beta-isopropylmalate dehydrogenase activity" RELATED [EC:1.1.1.85]
synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85]
synonym: "IMDH activity" RELATED [EC:1.1.1.85]
synonym: "IPMDH" RELATED [EC:1.1.1.85]
synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" RELATED [EC:1.1.1.85]
xref: EC:1.1.1.85
xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN
xref: RHEA:32271
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003863
name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
namespace: molecular_function
alt_id: GO:0003826
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4]
synonym: "2-oxoisocaproate dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" RELATED [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" RELATED [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" RELATED [EC:1.2.4.4]
synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "alpha-ketoacid dehydrogenase activity" NARROW []
synonym: "alpha-ketoisocaproate dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "alpha-ketoisovalerate dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "alpha-oxoisocaproate dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "BCKDH activity" RELATED [EC:1.2.4.4]
synonym: "BCOAD activity" RELATED [EC:1.2.4.4]
synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" RELATED [EC:1.2.4.4]
synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4]
xref: EC:1.2.4.4
xref: MetaCyc:1.2.4.4-RXN
xref: RHEA:13457
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0003864
name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11]
synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11]
synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11]
synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11]
synonym: "dehydropantoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11]
synonym: "ketopantoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11]
synonym: "oxopantoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11]
xref: EC:2.1.2.11
xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
xref: RHEA:11824
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0003865
name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5]
synonym: "3-keto-delta4-steroid-5alpha-reductase activity" RELATED [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" RELATED [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" RELATED [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" RELATED [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" RELATED [EC:1.3.99.5]
synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5]
synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" RELATED [EC:1.3.99.5]
synonym: "5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-3-keto steroid 5alpha-reductase activity" RELATED [EC:1.3.99.5]
synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" RELATED [EC:1.3.99.5]
synonym: "delta4-3-oxo steroid reductase activity" RELATED [EC:1.3.99.5]
synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-5alpha-dehydrogenase activity" RELATED [EC:1.3.99.5]
synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5]
synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5]
synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "steroid delta4-5alpha-reductase activity" RELATED [EC:1.3.99.5]
synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5]
xref: EC:1.3.99.5
xref: MetaCyc:RXN-13682
xref: Reactome:R-HSA-469659 "SRD5A1 dehydrogenates TEST to DHTEST"
xref: Reactome:R-HSA-9705713 "SRD5A2 dehydrogenates TEST to DHTEST"
xref: Reactome:R-HSA-9705714 "SRD5A3 dehydrogenates TEST to DHTEST"
xref: RHEA:13805
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0003866
name: 3-phosphoshikimate 1-carboxyvinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21256]
synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" RELATED [EC:2.5.1.19]
synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" RELATED [EC:2.5.1.19]
synonym: "EPSP synthase activity" RELATED [EC:2.5.1.19]
synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" RELATED [EC:2.5.1.19]
xref: EC:2.5.1.19
xref: KEGG_REACTION:R03460
xref: MetaCyc:2.5.1.19-RXN
xref: RHEA:21256
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003867
name: obsolete 4-aminobutyrate transaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [GOC:mah]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "4-aminobutanoate transaminase activity" EXACT []
synonym: "4-aminobutyrate aminotransferase activity" EXACT []
synonym: "4-aminobutyric acid aminotransferase activity" EXACT []
synonym: "aminobutyrate aminotransferase activity" EXACT []
synonym: "aminobutyrate transaminase activity" EXACT []
synonym: "beta-alanine aminotransferase" RELATED []
synonym: "GABA aminotransferase activity" EXACT []
synonym: "GABA transaminase activity" EXACT []
synonym: "GABA transferase activity" EXACT []
synonym: "gamma-amino-N-butyrate transaminase activity" EXACT []
synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT []
synonym: "gamma-aminobutyrate transaminase activity" EXACT []
synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT []
synonym: "gamma-aminobutyric acid transaminase activity" EXACT []
synonym: "gamma-aminobutyric transaminase activity" EXACT []
synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT []
xref: Reactome:R-HSA-916855 "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA"
is_obsolete: true
consider: GO:0034386
consider: GO:0034387

[Term]
id: GO:0003868
name: 4-hydroxyphenylpyruvate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27]
synonym: "4-hydroxyphenylpyruvate hydroxylase activity" RELATED [EC:1.13.11.27]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" RELATED [EC:1.13.11.27]
synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" RELATED [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate dioxygenase activity" RELATED [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate hydroxylase activity" RELATED [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate oxidase activity" RELATED [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" RELATED [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic hydroxylase activity" RELATED [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic oxidase activity" RELATED [EC:1.13.11.27]
xref: EC:1.13.11.27
xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN
xref: Reactome:R-HSA-71163 "HPD dioxygenates HPP"
xref: RHEA:16189
xref: UM-BBD_reactionID:r0298
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0003870
name: 5-aminolevulinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA." [EC:2.3.1.37, RHEA:12921]
synonym: "5-aminolevulinate synthetase activity" RELATED [EC:2.3.1.37]
synonym: "5-aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37]
synonym: "5-aminolevulinic acid synthetase activity" RELATED [EC:2.3.1.37]
synonym: "ALA synthase activity" RELATED [EC:2.3.1.37]
synonym: "ALA synthetase activity" RELATED [EC:2.3.1.37]
synonym: "ALAS activity" RELATED [EC:2.3.1.37]
synonym: "alpha-aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37]
synonym: "aminolevulinate synthase activity" RELATED [EC:2.3.1.37]
synonym: "aminolevulinate synthetase activity" RELATED [EC:2.3.1.37]
synonym: "aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37]
synonym: "aminolevulinic acid synthetase activity" RELATED [EC:2.3.1.37]
synonym: "aminolevulinic synthetase activity" RELATED [EC:2.3.1.37]
synonym: "delta-ALA synthetase activity" RELATED [EC:2.3.1.37]
synonym: "delta-aminolevulinate synthase activity" RELATED [EC:2.3.1.37]
synonym: "delta-aminolevulinate synthetase activity" RELATED [EC:2.3.1.37]
synonym: "delta-aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37]
synonym: "delta-aminolevulinic acid synthetase activity" RELATED [EC:2.3.1.37]
synonym: "delta-aminolevulinic synthetase activity" RELATED [EC:2.3.1.37]
synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" RELATED [EC:2.3.1.37]
xref: EC:2.3.1.37
xref: KEGG_REACTION:R00830
xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN
xref: Reactome:R-HSA-189442 "ALAS condenses SUCC-CoA and Gly to form dALA"
xref: RHEA:12921
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0003871
name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21196]
synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.14]
synonym: "cobalamin-independent methionine synthase activity" RELATED [EC:2.1.1.14]
synonym: "homocysteine methylase activity" RELATED [EC:2.1.1.14]
synonym: "MetE" RELATED [EC:2.1.1.14]
synonym: "methionine synthase (cobalamin-independent) activity" RELATED [EC:2.1.1.14]
synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" RELATED [EC:2.1.1.14]
synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" RELATED [EC:2.1.1.14]
synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" RELATED [EC:2.1.1.14]
synonym: "tetrahydropteroyltriglutamate methyltransferase activity" RELATED [EC:2.1.1.14]
xref: EC:2.1.1.14
xref: KEGG_REACTION:R04405
xref: MetaCyc:HOMOCYSMET-RXN
xref: RHEA:21196
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity

[Term]
id: GO:0003872
name: 6-phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11]
synonym: "6-phosphofructokinase reduction" EXACT []
synonym: "6-phosphofructose 1-kinase activity" RELATED [EC:2.7.1.11]
synonym: "ATP-dependent phosphofructokinase activity" RELATED [EC:2.7.1.11]
synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.11]
synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.11]
synonym: "fructose 6-phosphate kinase activity" RELATED [EC:2.7.1.11]
synonym: "fructose 6-phosphokinase activity" RELATED [EC:2.7.1.11]
synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" RELATED [EC:2.7.1.11]
synonym: "PFK" RELATED [EC:2.7.1.11]
synonym: "phospho-1,6-fructokinase activity" RELATED [EC:2.7.1.11]
synonym: "phosphofructokinase (phosphorylating)" RELATED [EC:2.7.1.11]
synonym: "phosphofructokinase I activity" RELATED [EC:2.7.1.11]
synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11]
xref: EC:2.7.1.11
xref: MetaCyc:6PFRUCTPHOS-RXN
xref: Reactome:R-HSA-70467 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP"
xref: RHEA:16109
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0003873
name: 6-phosphofructo-2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+." [EC:2.7.1.105, RHEA:15653]
synonym: "6-phosphofructo-2-kinase (phosphorylating)" RELATED [EC:2.7.1.105]
synonym: "6-phosphofructose 2-kinase activity" RELATED [EC:2.7.1.105]
synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" RELATED [EC:2.7.1.105]
synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" RELATED [EC:2.7.1.105]
synonym: "fructose 6-phosphate 2-kinase activity" RELATED [EC:2.7.1.105]
synonym: "phosphofructokinase 2 activity" RELATED [EC:2.7.1.105]
xref: EC:2.7.1.105
xref: KEGG_REACTION:R02732
xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN
xref: Reactome:R-HSA-71802 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP"
xref: RHEA:15653
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0003874
name: 6-pyruvoyltetrahydropterin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate." [EC:4.2.3.12, RHEA:22048]
synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" RELATED [EC:4.2.3.12]
synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" RELATED [EC:4.2.3.12]
synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" RELATED [EC:4.2.3.12]
synonym: "PTPS activity" RELATED [EC:4.2.3.12]
xref: EC:4.2.3.12
xref: KEGG_REACTION:R04286
xref: MetaCyc:4.2.3.12-RXN
xref: Reactome:R-HSA-1474184 "DHNTP is dephosphorylated by PTPS to PTHP"
xref: RHEA:22048
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0003875
name: ADP-ribosylarginine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reactions: H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein], and H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine." [EC:3.2.2.19]
synonym: "ADP-ribose-L-arginine cleavage enzyme activity" RELATED [EC:3.2.2.19]
synonym: "ADP-ribose-L-arginine cleaving enzyme activity" RELATED [EC:3.2.2.19]
synonym: "ADPribosylarginine hydrolase activity" EXACT []
synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19]
synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19]
synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19]
synonym: "protein ADP-ribosylarginine hydrolase activity" RELATED [EC:3.2.2.19]
synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19]
xref: EC:3.2.2.19
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0003876
name: AMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6]
synonym: "5-adenylate deaminase activity" RELATED [EC:3.5.4.6]
synonym: "5-adenylic acid deaminase activity" RELATED [EC:3.5.4.6]
synonym: "5-AMP deaminase activity" RELATED [EC:3.5.4.6]
synonym: "adenosine 5-monophosphate deaminase activity" RELATED [EC:3.5.4.6]
synonym: "adenosine 5-phosphate aminohydrolase activity" RELATED [EC:3.5.4.6]
synonym: "adenosine monophosphate deaminase activity" RELATED [EC:3.5.4.6]
synonym: "adenyl deaminase activity" RELATED [EC:3.5.4.6]
synonym: "adenylate aminohydrolase activity" RELATED [EC:3.5.4.6]
synonym: "adenylate deaminase activity" RELATED [EC:3.5.4.6]
synonym: "adenylate deaminase reaction" EXACT []
synonym: "adenylate desaminase activity" RELATED [EC:3.5.4.6]
synonym: "adenylic acid deaminase activity" RELATED [EC:3.5.4.6]
synonym: "adenylic deaminase activity" RELATED [EC:3.5.4.6]
synonym: "AMP aminase activity" RELATED [EC:3.5.4.6]
synonym: "AMP aminohydrolase activity" RELATED [EC:3.5.4.6]
synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6]
xref: EC:3.5.4.6
xref: MetaCyc:AMP-DEAMINASE-RXN
xref: Reactome:R-HSA-76590 "AMP + H2O => IMP + NH4+ (AMPD)"
xref: RHEA:14777
is_a: GO:0047623 ! adenosine-phosphate deaminase activity

[Term]
id: GO:0003877
name: ATP:ADP adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53]
synonym: "adenine triphosphate adenylyltransferase activity" RELATED [EC:2.7.7.53]
synonym: "AP-4-A phosphorylase activity" RELATED [EC:2.7.7.53]
synonym: "ATP adenylyltransferase activity" BROAD []
synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" RELATED [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" RELATED [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" RELATED [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" RELATED [EC:2.7.7.53]
synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" RELATED [EC:2.7.7.53]
synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" RELATED [EC:2.7.7.53]
synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" RELATED [EC:2.7.7.53]
xref: EC:2.7.7.53
xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN
xref: RHEA:16577
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0003878
name: ATP citrate synthase activity
namespace: molecular_function
alt_id: GO:0046913
def: "Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA." [RHEA:21160]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" RELATED [EC:2.3.3.8]
synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" RELATED [EC:2.3.3.8]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8]
synonym: "adenosine triphosphate citrate lyase activity" RELATED [EC:2.3.3.8]
synonym: "ATP citrate (pro-S)-lyase activity" RELATED [EC:2.3.3.8]
synonym: "ATP-citrate (pro-S)-lyase activity" EXACT []
synonym: "ATP-citrate (pro-S-)-lyase activity" RELATED [EC:2.3.3.8]
synonym: "ATP-citric lyase activity" RELATED [EC:2.3.3.8]
synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" RELATED [EC:2.3.3.8]
synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8]
synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8]
synonym: "citrate-ATP lyase activity" RELATED [EC:2.3.3.8]
synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8]
xref: EC:2.3.3.8
xref: KEGG_REACTION:R00352
xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN
xref: Reactome:R-HSA-75848 "ACLY tetramer transforms CIT to Ac-CoA"
xref: RHEA:21160
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0003879
name: ATP phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17]
synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" RELATED [EC:2.4.2.17]
synonym: "adenosine triphosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyl ATP synthetase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP diphosphorylase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP pyrophosphorylase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate synthetase activity" RELATED [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.17]
xref: EC:2.4.2.17
xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN
xref: RHEA:18473
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0003880
name: protein C-terminal carboxyl O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937]
synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT []
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity

[Term]
id: GO:0003881
name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+." [EC:2.7.8.11, RHEA:11580]
synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "CDP-DG:inositol transferase activity" RELATED [EC:2.7.8.11]
synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "CDP-diglyceride-inositol transferase activity" RELATED [EC:2.7.8.11]
synonym: "CDP-diglyceride:inositol transferase activity" RELATED [EC:2.7.8.11]
synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11]
synonym: "cytidine diphosphoglyceride-inositol transferase activity" RELATED [EC:2.7.8.11]
synonym: "phosphatidylinositol synthase activity" EXACT []
xref: EC:2.7.8.11
xref: KEGG_REACTION:R01802
xref: MetaCyc:2.7.8.11-RXN
xref: Reactome:R-HSA-1482976 "CDP-DAG is converted to PI by CDIPT"
xref: RHEA:11580
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0003882
name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8]
synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8]
synonym: "phosphatidylserine synthase activity" RELATED [EC:2.7.8.8]
synonym: "phosphatidylserine synthetase activity" RELATED [EC:2.7.8.8]
synonym: "PS synthase activity" RELATED [EC:2.7.8.8]
synonym: "serine exchange enzyme" BROAD []
xref: EC:2.7.8.8
xref: MetaCyc:PHOSPHASERSYN-RXN
xref: RHEA:16913
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0003883
name: CTP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate." [PMID:12354108, RHEA:26426]
synonym: "CTP synthetase activity" RELATED [EC:6.3.4.2]
synonym: "cytidine 5'-triphosphate synthetase activity" RELATED [EC:6.3.4.2]
synonym: "cytidine triphosphate synthetase activity" RELATED [EC:6.3.4.2]
synonym: "uridine triphosphate aminase activity" RELATED [EC:6.3.4.2]
synonym: "UTP--ammonia ligase activity" RELATED [EC:6.3.4.2]
synonym: "UTP:ammonia ligase (ADP-forming)" RELATED [EC:6.3.4.2]
xref: EC:6.3.4.2
xref: MetaCyc:CTPSYN-RXN
xref: Reactome:R-HSA-504054 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]"
xref: Reactome:R-HSA-73647 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]"
xref: RHEA:26426
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0003884
name: D-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4+." [RHEA:21816]
synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.3]
synonym: "L-amino acid:O2 oxidoreductase activity" RELATED [EC:1.4.3.3]
synonym: "new yellow enzyme" RELATED [EC:1.4.3.3]
xref: EC:1.4.3.3
xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN
xref: Reactome:R-HSA-389821 "glycine + O2 => glyoxylate + H2O2 + NH4+"
xref: RHEA:21816
is_a: GO:0008131 ! primary methylamine oxidase activity

[Term]
id: GO:0003885
name: D-arabinono-1,4-lactone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+." [EC:1.1.3.37, RHEA:23756]
synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" RELATED [EC:1.1.3.37]
xref: EC:1.1.3.37
xref: KEGG_REACTION:R02715
xref: MetaCyc:1.1.3.37-RXN
xref: RHEA:23756
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0003886
name: DNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
alt_id: GO:0008326
def: "Catalysis of the reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine." [RHEA:13681]
synonym: "cytosine 5-methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37]
synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37]
synonym: "cytosine-specific DNA methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37]
synonym: "DNA 5-cytosine methylase activity" RELATED [EC:2.1.1.37]
synonym: "DNA cytosine C(5) methylase activity" RELATED [EC:2.1.1.37]
synonym: "DNA cytosine C5 methylase activity" RELATED [EC:2.1.1.37]
synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37]
synonym: "DNA-cytosine 5-methylase activity" RELATED [EC:2.1.1.37]
synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37]
synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "modification methylase activity" RELATED [EC:2.1.1.37]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37]
synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37]
synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37]
xref: EC:2.1.1.37
xref: MetaCyc:DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN
xref: RHEA:13681
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity

[Term]
id: GO:0003887
name: DNA-directed DNA polymerase activity
namespace: molecular_function
alt_id: GO:0003888
alt_id: GO:0003889
alt_id: GO:0003890
alt_id: GO:0003891
alt_id: GO:0003893
alt_id: GO:0003894
alt_id: GO:0003895
alt_id: GO:0008723
alt_id: GO:0015999
alt_id: GO:0016000
alt_id: GO:0016448
alt_id: GO:0016449
alt_id: GO:0016450
alt_id: GO:0016451
alt_id: GO:0016452
alt_id: GO:0019984
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time." [EC:2.7.7.7, GOC:vw]
synonym: "alpha DNA polymerase activity" NARROW []
synonym: "beta DNA polymerase activity" NARROW []
synonym: "delta DNA polymerase activity" NARROW []
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.7]
synonym: "deoxyribonucleic acid duplicase activity" RELATED [EC:2.7.7.7]
synonym: "deoxyribonucleic duplicase activity" RELATED [EC:2.7.7.7]
synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7]
synonym: "DNA duplicase activity" RELATED [EC:2.7.7.7]
synonym: "DNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.7]
synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase I" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase II" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase III" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase V activity" NARROW []
synonym: "DNA replicase activity" RELATED [EC:2.7.7.7]
synonym: "DNA-dependent DNA polymerase activity" RELATED [EC:2.7.7.7]
synonym: "duplicase" BROAD [EC:2.7.7.7]
synonym: "epsilon DNA polymerase activity" NARROW []
synonym: "eta DNA polymerase activity" NARROW []
synonym: "gamma DNA-directed DNA polymerase activity" NARROW []
synonym: "iota DNA polymerase activity" NARROW []
synonym: "kappa DNA polymerase activity" NARROW []
synonym: "Klenow fragment" NARROW [EC:2.7.7.7]
synonym: "lambda DNA polymerase activity" NARROW []
synonym: "mu DNA polymerase activity" NARROW []
synonym: "nu DNA polymerase activity" NARROW []
synonym: "sequenase" RELATED [EC:2.7.7.7]
synonym: "sigma DNA polymerase activity" NARROW []
synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7]
synonym: "Taq Pol I" NARROW [EC:2.7.7.7]
synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7]
synonym: "theta DNA polymerase activity" NARROW []
synonym: "zeta DNA polymerase activity" NARROW []
xref: EC:2.7.7.7
xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN
xref: Reactome:R-HSA-110311 "POLZ extends translesion synthesis"
xref: Reactome:R-HSA-110317 "Insertion of correct bases opposite the lesion by POLH"
xref: Reactome:R-HSA-110319 "Elongation by POLH"
xref: Reactome:R-HSA-110368 "POLD,POLE-mediated DNA strand displacement synthesis"
xref: Reactome:R-HSA-111253 "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site"
xref: Reactome:R-HSA-164505 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand"
xref: Reactome:R-HSA-164513 "3' PPT-primed initiation of plus-strand DNA synthesis"
xref: Reactome:R-HSA-174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:R-HSA-174444 "Formation of C-strand Okazaki fragments"
xref: Reactome:R-HSA-5358579 "DNA polymerase delta polymerizes DNA across single stranded gap"
xref: Reactome:R-HSA-5649723 "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution"
xref: Reactome:R-HSA-5649883 "POLB-mediated DNA strand displacement synthesis"
xref: Reactome:R-HSA-5653840 "POLD,POLE complete replication of damaged DNA after TLS"
xref: Reactome:R-HSA-5655892 "POLK incorporates dNMP opposite to damaged DNA base"
xref: Reactome:R-HSA-5655965 "POLK and POLZ cooperate in elongation of mispaired primer termini"
xref: Reactome:R-HSA-5656148 "POLI incorporates dNMP opposite to damaged DNA base"
xref: Reactome:R-HSA-5656158 "POLZ elongates POLI-incorporated dNMP"
xref: Reactome:R-HSA-5687360 "POLL or POLM extends aligned DNA DSB ends to fill gaps"
xref: Reactome:R-HSA-5687640 "POLQ extends annealed 3'-ssDNA overhangs in MMEJ"
xref: Reactome:R-HSA-5691001 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER"
xref: Reactome:R-HSA-5693593 "D-loop extension by DNA polymerases"
xref: Reactome:R-HSA-6782208 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER"
xref: Reactome:R-HSA-6786166 "Translesion synthesis across unhooked ICL by POLN"
xref: Reactome:R-HSA-68950 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin"
xref: Reactome:R-HSA-69116 "Formation of Okazaki fragments"
xref: Reactome:R-HSA-73932 "Resynthesis of excised residue by POLB"
xref: Reactome:R-HSA-9710480 "Decitabine triphosphate incorporates into DNA"
is_a: GO:0034061 ! DNA polymerase activity

[Term]
id: GO:0003892
name: obsolete proliferating cell nuclear antigen
namespace: molecular_function
alt_id: GO:0005661
def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387]
comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "PCNA" EXACT []
synonym: "proliferating cell nuclear antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0003896
name: DNA primase activity
namespace: molecular_function
alt_id: GO:0003897
alt_id: GO:0003898
def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [GOC:mah, GOC:mcc, PMID:11395402, PMID:26184436, PMID:38203225, PMID:38492718]
is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity

[Term]
id: GO:0003899
name: DNA-directed 5'-3' RNA polymerase activity
namespace: molecular_function
alt_id: GO:0000129
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]
synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6]
synonym: "C RNA formation factors" RELATED [EC:2.7.7.6]
synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" RELATED [EC:2.7.7.6]
synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.6]
synonym: "DNA-dependent RNA nucleotidyltransferase activity" RELATED [EC:2.7.7.6]
synonym: "DNA-dependent RNA polymerase activity" RELATED [EC:2.7.7.6]
synonym: "DNA-directed RNA polymerase activity" BROAD []
synonym: "DNA-directed RNA polymerase I activity" NARROW []
synonym: "DNA-directed RNA polymerase II activity" NARROW []
synonym: "DNA-directed RNA polymerase III activity" NARROW []
synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.6]
synonym: "RNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.6]
synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6]
synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6]
synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6]
synonym: "transcriptase" BROAD [EC:2.7.7.6]
xref: EC:2.7.7.6
xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN
xref: Reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30"
xref: Reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition"
xref: Reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript"
xref: Reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition"
xref: Reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript"
xref: Reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript"
xref: Reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes"
xref: Reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene"
xref: Reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript"
xref: Reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template"
xref: Reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin"
xref: Reactome:R-HSA-74986 "Elongation of pre-rRNA transcript"
xref: Reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript"
xref: Reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition"
xref: Reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript"
xref: Reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition"
xref: Reactome:R-HSA-9670149 "TERRA transcription"
xref: Reactome:R-HSA-9697084 "Defective RpoB in Mtb RNAP transcribes RNA polyanion"
xref: Reactome:R-HSA-9697085 "RNAP transcribes Mtb RNA polyanion"
is_a: GO:0034062 ! 5'-3' RNA polymerase activity

[Term]
id: GO:0003900
name: obsolete DNA-directed RNA polymerase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [GOC:curators]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'.
synonym: "DNA-directed RNA polymerase I activity" EXACT []
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003901
name: obsolete DNA-directed RNA polymerase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [GOC:curators]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'.
synonym: "DNA-directed RNA polymerase II activity" EXACT []
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003902
name: obsolete DNA-directed RNA polymerase III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [GOC:curators]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'.
synonym: "DNA-directed RNA polymerase III activity" EXACT []
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003904
name: deoxyribodipyrimidine photo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]
synonym: "CPD photolyase activity" EXACT [PMID:16302973]
synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" RELATED [EC:4.1.99.3]
synonym: "deoxyribodipyrimidine photolyase activity" EXACT []
synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" RELATED [EC:4.1.99.3]
synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" RELATED [EC:4.1.99.3]
synonym: "deoxyribonucleic photolyase activity" RELATED [EC:4.1.99.3]
synonym: "dipyrimidine photolyase (photosensitive)" RELATED [EC:4.1.99.3]
synonym: "DNA cyclobutane dipyrimidine photolyase activity" RELATED [EC:4.1.99.3]
synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3]
synonym: "photolyase activity" RELATED [EC:4.1.99.3]
synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3]
synonym: "phr A photolyase activity" RELATED [EC:4.1.99.3]
synonym: "PhrB photolyase activity" RELATED [EC:4.1.99.3]
synonym: "PRE" RELATED [EC:4.1.99.3]
xref: EC:4.1.99.3
xref: RHEA:10672
is_a: GO:0003913 ! DNA photolyase activity

[Term]
id: GO:0003905
name: alkylbase DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0004036
def: "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]
synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21]
synonym: "AlkA" RELATED [EC:3.2.2.21]
synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21]
synonym: "alkylbase DNA glycosidase activity" EXACT []
synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21]
synonym: "DNA glycosidase II activity" RELATED [EC:3.2.2.21]
synonym: "DNA-3-methyladenine glycosidase II activity" EXACT []
synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21]
xref: EC:3.2.2.21
xref: MetaCyc:3.2.2.21-RXN
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0003906
name: DNA-(apurinic or apyrimidinic site) endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease]
comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
synonym: "abasic deoxyendoribonuclease activity" EXACT []
synonym: "AP deoxyendoribonuclease activity" EXACT []
synonym: "apurinic deoxyendoribonuclease activity" EXACT []
synonym: "apurinic/apyrimidinic endodeoxyribonuclease activity" EXACT []
synonym: "apyrimidinic deoxyendoribonuclease activity" EXACT []
synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT []
synonym: "endonuclease VIII activity" RELATED []
synonym: "UV endonuclease" BROAD []
xref: Reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break"
xref: Reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site"
xref: Reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)"
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0003908
name: methylated-DNA-[protein]-cysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]
synonym: "6-O-methylguanine-DNA methyltransferase activity" RELATED [EC:2.1.1.63]
synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT []
synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" RELATED [EC:2.1.1.63]
synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" RELATED [EC:2.1.1.63]
synonym: "MGMT" EXACT []
synonym: "O-6-methylguanine-DNA-alkyltransferase activity" RELATED [EC:2.1.1.63]
synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD []
xref: EC:2.1.1.63
xref: MetaCyc:2.1.1.63-RXN
xref: Reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal"
xref: RHEA:24000
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity

[Term]
id: GO:0003909
name: DNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]
xref: Reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA"
xref: Reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA"
xref: Reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break"
xref: Reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB"
xref: Reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB"
xref: Reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ"
xref: Reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER"
xref: Reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ"
xref: Reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER"
xref: Reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments"
xref: Reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway"
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0003910
name: DNA ligase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]
synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "DNA joinase activity" BROAD [EC:6.5.1.1]
synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1]
synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" RELATED [EC:6.5.1.1]
synonym: "polydeoxyribonucleotide synthase (ATP) activity" RELATED [EC:6.5.1.1]
synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1]
synonym: "polynucleotide ligase (ATP) activity" RELATED [EC:6.5.1.1]
synonym: "sealase activity" RELATED [EC:6.5.1.1]
xref: EC:6.5.1.1
xref: MetaCyc:DNA-LIGASE-ATP-RXN
is_a: GO:0003909 ! DNA ligase activity

[Term]
id: GO:0003911
name: DNA ligase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2]
synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2]
synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2]
synonym: "DNA joinase activity" BROAD [EC:6.5.1.2]
synonym: "DNA ligase (NAD)" RELATED [EC:6.5.1.2]
synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2]
synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2]
synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" RELATED [EC:6.5.1.2]
synonym: "polydeoxyribonucleotide synthase (NAD(+)) activity" RELATED [EC:6.5.1.2]
synonym: "polydeoxyribonucleotide synthase (NAD)" RELATED [EC:6.5.1.2]
synonym: "polydeoxyribonucleotide synthase (NAD+) activity" RELATED [EC:6.5.1.2]
synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD(+)) activity" RELATED [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD)" RELATED [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD+) activity" RELATED [EC:6.5.1.2]
synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" RELATED [EC:6.5.1.2]
synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" RELATED [EC:6.5.1.2]
synonym: "polynucleotide synthetase activity" RELATED [EC:6.5.1.2]
xref: EC:6.5.1.2
xref: MetaCyc:DNA-LIGASE-NAD+-RXN
is_a: GO:0003909 ! DNA ligase activity

[Term]
id: GO:0003912
name: DNA nucleotidylexotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time." [EC:2.7.7.31]
synonym: "addase activity" RELATED [EC:2.7.7.31]
synonym: "deoxynucleotidyl terminal transferase activity" RELATED [EC:2.7.7.31]
synonym: "deoxyribonucleic acid nucleotidyltransferase activity" RELATED [EC:2.7.7.31]
synonym: "deoxyribonucleic nucleotidyltransferase activity" RELATED [EC:2.7.7.31]
synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" RELATED [EC:2.7.7.31]
synonym: "TdT" RELATED [EC:2.7.7.31]
synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31]
synonym: "terminal deoxynucleotide transferase activity" RELATED [EC:2.7.7.31]
synonym: "terminal deoxynucleotidyltransferase activity" RELATED [EC:2.7.7.31]
synonym: "terminal deoxyribonucleotidyltransferase activity" RELATED [EC:2.7.7.31]
synonym: "terminal transferase activity" RELATED [EC:2.7.7.31]
xref: EC:2.7.7.31
xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN
is_a: GO:0034061 ! DNA polymerase activity

[Term]
id: GO:0003913
name: DNA photolyase activity
namespace: molecular_function
def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]
is_a: GO:0016830 ! carbon-carbon lyase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0003914
name: DNA (6-4) photolyase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949]
xref: EC:4.1.99.13
xref: MetaCyc:RXN-10771
is_a: GO:0003913 ! DNA photolyase activity

[Term]
id: GO:0003916
name: DNA topoisomerase activity
namespace: molecular_function
alt_id: GO:0009387
def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]
is_a: GO:0016853 ! isomerase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0003917
name: DNA topoisomerase type I (single strand cut, ATP-independent) activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]
comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
synonym: "deoxyribonucleate topoisomerase" BROAD []
synonym: "DNA topoisomerase I activity" NARROW []
synonym: "nicking-closing enzyme activity" RELATED [EC:5.6.2.1]
synonym: "omega-protein activity" RELATED [EC:5.6.2.1]
synonym: "relaxing enzyme activity" RELATED [EC:5.6.2.1]
synonym: "swivelase activity" RELATED [EC:5.6.2.1]
synonym: "topoisomerase" BROAD [EC:5.6.2.1]
synonym: "type I DNA topoisomerase activity" EXACT []
synonym: "type I topoisomerase activity" EXACT []
synonym: "untwisting enzyme activity" RELATED [EC:5.6.2.1]
xref: EC:5.6.2.1
xref: MetaCyc:5.99.1.2-RXN
is_a: GO:0003916 ! DNA topoisomerase activity

[Term]
id: GO:0003918
name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
namespace: molecular_function
alt_id: GO:0061505
def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2." [PMID:8811192]
synonym: "deoxyribonucleate topoisomerase" BROAD [GOC:krc]
synonym: "deoxyribonucleic topoisomerase activity" BROAD [EC:5.6.2.2, GOC:krc]
synonym: "DNA topoisomerase (ATP-hydrolysing)" RELATED [EC:5.6.2.2, GOC:krc]
synonym: "DNA topoisomerase II" NARROW [EC:5.6.2.2, GOC:krc]
synonym: "DNA topoisomerase II activity" NARROW [GOC:krc]
synonym: "DNA topoisomerase IV activity" NARROW [GOC:krc]
synonym: "DNA topoisomerase type II activity" EXACT [GOC:krc]
synonym: "topoisomerase" BROAD [EC:5.6.2.2, GOC:krc]
synonym: "topoisomerase II" NARROW [GOC:krc]
synonym: "type II DNA topoisomerase activity" RELATED [EC:5.6.2.2, GOC:krc]
xref: EC:5.6.2.2
xref: MetaCyc:5.99.1.3-RXN
xref: Wikipedia:Type_II_topoisomerase
is_a: GO:0003916 ! DNA topoisomerase activity
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0003919
name: FMN adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17237]
synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" RELATED [EC:2.7.7.2]
synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" RELATED [EC:2.7.7.2]
synonym: "ATP:FMN adenylyltransferase activity" EXACT []
synonym: "FAD diphosphorylase activity" RELATED [EC:2.7.7.2]
synonym: "FAD pyrophosphorylase activity" RELATED [EC:2.7.7.2]
synonym: "FAD synthetase activity" RELATED [EC:2.7.7.2]
synonym: "flavin adenine dinucleotide synthetase activity" RELATED [EC:2.7.7.2]
synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.2]
synonym: "riboflavin mononucleotide adenylyltransferase activity" RELATED [EC:2.7.7.2]
synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" RELATED [EC:2.7.7.2]
xref: EC:2.7.7.2
xref: KEGG_REACTION:R00161
xref: MetaCyc:FADSYN-RXN
xref: Reactome:R-HSA-196929 "FLAD1 phosphorylates FMN"
xref: RHEA:17237
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0003920
name: GMP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH." [EC:1.7.1.7, RHEA:17185]
synonym: "guanosine 5'-monophosphate oxidoreductase activity" RELATED [EC:1.7.1.7]
synonym: "guanosine 5'-monophosphate reductase activity" RELATED [EC:1.7.1.7]
synonym: "guanosine 5'-phosphate reductase activity" RELATED [EC:1.7.1.7]
synonym: "guanosine monophosphate reductase activity" RELATED [EC:1.7.1.7]
synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7]
synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" RELATED [EC:1.7.1.7]
synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" RELATED [EC:1.7.1.7]
synonym: "NADPH:GMP oxidoreductase (deaminating) activity" RELATED [EC:1.7.1.7]
synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" RELATED [EC:1.7.1.7]
xref: EC:1.7.1.7
xref: KEGG_REACTION:R01134
xref: MetaCyc:GMP-REDUCT-RXN
xref: Reactome:R-HSA-514604 "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)"
xref: RHEA:17185
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0003921
name: GMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+." [RHEA:18301]
xref: MetaCyc:GMP-SYN-NH3-RXN
xref: RHEA:18301
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
relationship: part_of GO:0003922 ! GMP synthase (glutamine-hydrolyzing) activity

[Term]
id: GO:0003922
name: GMP synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+." [RHEA:11680]
synonym: "glutamine amidotransferase activity" RELATED [EC:6.3.5.2]
synonym: "GMP synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.2]
synonym: "GMP synthetase (glutamine-hydrolysing)" RELATED [EC:6.3.5.2]
synonym: "GMP synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.2]
synonym: "guanosine 5'-monophosphate synthetase activity" RELATED [EC:6.3.5.2]
synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" RELATED [EC:6.3.5.2]
synonym: "guanylate synthetase (glutamine-hydrolyzing)" RELATED [EC:6.3.5.2]
synonym: "xanthosine 5'-phosphate amidotransferase activity" RELATED [EC:6.3.5.2]
synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" RELATED [EC:6.3.5.2]
xref: EC:6.3.5.2
xref: MetaCyc:GMP-SYN-GLUT-RXN
xref: Reactome:R-HSA-73792 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate"
xref: Reactome:R-HSA-9748957 "GMPS dimer transforms 6TXMP to 6TGMP"
xref: RHEA:11680
xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0003923
name: GPI-anchor transamidase activity
namespace: molecular_function
def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309]
xref: Reactome:R-HSA-162836 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide"
is_a: GO:0004197 ! cysteine-type endopeptidase activity
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0003924
name: GTPase activity
namespace: molecular_function
alt_id: GO:0061745
def: "Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "ARF small monomeric GTPase activity" NARROW []
synonym: "dynamin GTPase activity" NARROW []
synonym: "GTPase activity, coupled" RELATED []
synonym: "heterotrimeric G-protein GTPase activity" NARROW []
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED []
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED []
synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD []
synonym: "protein-synthesizing GTPase activity" NARROW []
synonym: "protein-synthesizing GTPase activity, elongation" NARROW []
synonym: "protein-synthesizing GTPase activity, initiation" NARROW []
synonym: "protein-synthesizing GTPase activity, termination" NARROW []
synonym: "Rab small monomeric GTPase activity" NARROW []
synonym: "Ran small monomeric GTPase activity" NARROW []
synonym: "Ras small monomeric GTPase activity" NARROW []
synonym: "RHEB small monomeric GTPase activity" NARROW []
synonym: "Rho small monomeric GTPase activity" NARROW []
synonym: "Sar small monomeric GTPase activity" NARROW []
synonym: "signal-recognition-particle GTPase activity" NARROW []
synonym: "small monomeric GTPase activity" NARROW []
synonym: "tubulin GTPase activity" NARROW []
xref: MetaCyc:RXN0-5462
xref: Reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP"
xref: Reactome:R-HSA-1458485 "RALA hydrolyzes GTP"
xref: Reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP"
xref: Reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP"
xref: Reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP"
xref: Reactome:R-HSA-167415 "G-protein alpha subunit is inactivated"
xref: Reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf"
xref: Reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf"
xref: Reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha"
xref: Reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle"
xref: Reactome:R-HSA-203973 "Vesicle budding"
xref: Reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome"
xref: Reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle"
xref: Reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP"
xref: Reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP"
xref: Reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP"
xref: Reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP"
xref: Reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP"
xref: Reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP"
xref: Reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission"
xref: Reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha"
xref: Reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission"
xref: Reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC"
xref: Reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA"
xref: Reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome"
xref: Reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits"
xref: Reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)"
xref: Reactome:R-HSA-555065 "Formation of clathrin coated vesicle"
xref: Reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4"
xref: Reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP"
xref: Reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity"
xref: Reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments"
xref: Reactome:R-HSA-5672017 "Rheb in the MTORC1 complex hydrolyses GTP"
xref: Reactome:R-HSA-5694527 "Loss of SAR1B GTPase"
xref: Reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity"
xref: Reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP"
xref: Reactome:R-HSA-8847534 "RAB43 hydrolyses GTP"
xref: Reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity"
xref: Reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity"
xref: Reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35"
xref: Reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7"
xref: Reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7"
xref: Reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A"
xref: Reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B"
xref: Reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission"
xref: Reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity"
xref: Reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated"
xref: Reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated"
xref: Reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated"
xref: Reactome:R-HSA-9018814 "RHOT1 hydrolyzes GTP"
xref: Reactome:R-HSA-9018826 "RHOT2 hydrolyzes GTP"
xref: Reactome:R-HSA-9640195 "RRAGA,B hydrolyzes GTP"
xref: Reactome:R-HSA-9645598 "RRAGC,D hydrolyzes GTP"
xref: Reactome:R-HSA-9649736 "RAS intrinsic GTPase activity hydrolyzes GTP to GDP"
xref: Reactome:R-HSA-983422 "Disassembly of COPII coated vesicle"
xref: RHEA:19669
is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity

[Term]
id: GO:0003925
name: G protein activity
namespace: molecular_function
alt_id: GO:0003927
def: "A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]
synonym: "heterotrimeric G-protein GTPase activity" NARROW []
synonym: "large G-protein activity" NARROW []
synonym: "large G-protein GTPase activity" NARROW []
synonym: "Ras superfamily protein" NARROW []
synonym: "signaling G protein activity" EXACT []
synonym: "small G-protein" NARROW []
synonym: "small GTPase" NARROW []
synonym: "small GTPase activity" NARROW []
synonym: "small monomeric G protein activity" NARROW []
synonym: "small monomeric GTPase activity" NARROW []
xref: Reactome:R-HSA-400027 "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma"
xref: Reactome:R-HSA-400037 "Gi,Go Heterotrimeric G-protein complex dissociates"
xref: Reactome:R-HSA-422320 "Heterotrimeric G(s) complex dissociates"
is_a: GO:0003924 ! GTPase activity
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0003926
name: obsolete ARF small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "ARF small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0016191
consider: GO:0016192

[Term]
id: GO:0003928
name: obsolete RAB small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "RAB small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0016191
consider: GO:0016192

[Term]
id: GO:0003929
name: obsolete RAN small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "RAN small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0006606

[Term]
id: GO:0003930
name: obsolete RAS small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "RAS small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0001558

[Term]
id: GO:0003931
name: obsolete Rho small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "Rho small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0007010

[Term]
id: GO:0003932
name: obsolete SAR small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "SAR small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0046903

[Term]
id: GO:0003933
name: GTP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [GOC:curators]
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0003934
name: GTP cyclohydrolase I activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+." [EC:3.5.4.16]
synonym: "dihydroneopterin triphosphate synthase activity" RELATED [EC:3.5.4.16]
synonym: "GTP 7,8-8,9-dihydrolase activity" RELATED [EC:3.5.4.16]
synonym: "GTP 8-formylhydrolase activity" RELATED [EC:3.5.4.16]
synonym: "guanosine triphosphate 8-deformylase activity" RELATED [EC:3.5.4.16]
synonym: "guanosine triphosphate cyclohydrolase activity" RELATED [EC:3.5.4.16]
xref: EC:3.5.4.16
xref: KEGG_REACTION:R00424
xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN
xref: Reactome:R-HSA-1474146 "GCH1 reduces GTP to dihydroneopterin triphosphate"
xref: RHEA:17473
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0003935
name: GTP cyclohydrolase II activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate." [EC:3.5.4.25, RHEA:23704]
synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" RELATED [EC:3.5.4.25]
synonym: "GTP-8-formylhydrolase activity" RELATED [EC:3.5.4.25]
synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25]
xref: EC:3.5.4.25
xref: KEGG_REACTION:R00425
xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN
xref: RHEA:23704
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0003936
name: obsolete hydrogen-transporting two-sector ATPase activity
namespace: molecular_function
alt_id: GO:0004006
alt_id: GO:0008729
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-]
comment: This term was made obsolete because it refers to a bifunctional gene product.
synonym: "hydrogen-transporting two-sector ATPase activity" EXACT []
synonym: "proton-transporting two-sector ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046933
consider: GO:0046961

[Term]
id: GO:0003937
name: IMP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10]
synonym: "IMP 1,2-hydrolase (decyclizing)" RELATED [EC:3.5.4.10]
synonym: "IMP synthetase activity" RELATED [EC:3.5.4.10]
synonym: "inosinate cyclohydrolase activity" RELATED [EC:3.5.4.10]
synonym: "inosinicase activity" RELATED [EC:3.5.4.10]
xref: EC:3.5.4.10
xref: MetaCyc:IMPCYCLOHYDROLASE-RXN
xref: Reactome:R-HSA-73797 "FAICAR => IMP + H2O"
xref: RHEA:18445
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0003938
name: IMP dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205]
synonym: "IMP oxidoreductase activity" RELATED [EC:1.1.1.205]
synonym: "IMP:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.205]
synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205]
synonym: "inosine 5'-monophosphate dehydrogenase activity" RELATED [EC:1.1.1.205]
synonym: "inosine monophosphate dehydrogenase activity" RELATED [EC:1.1.1.205]
synonym: "inosine monophosphate oxidoreductase activity" RELATED [EC:1.1.1.205]
synonym: "inosine-5'-phosphate dehydrogenase activity" RELATED [EC:1.1.1.205]
synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205]
xref: EC:1.1.1.205
xref: MetaCyc:IMP-DEHYDROG-RXN
xref: Reactome:R-HSA-73794 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]"
xref: Reactome:R-HSA-9748945 "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP"
xref: RHEA:11708
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003939
name: L-iditol 2-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. Acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol." [EC:1.1.1.14, PMID:13373783]
synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "L-iditol:NAD oxidoreductase activity" RELATED [EC:1.1.1.14]
synonym: "L-iditol:NAD+ 5-oxidoreductase activity" RELATED [EC:1.1.1.14]
synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14]
synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14]
synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
xref: EC:1.1.1.14
xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-5652195 "SORD oxidizes D-sorbitol to Fru"
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0003940
name: L-iduronidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. Can also hydrolyze alpha-L-iduronosidic linkages in heparan sulfate." [EC:3.2.1.76, PMID:35011691]
synonym: "alpha-L-iduronidase activity" RELATED [EC:3.2.1.76]
synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" RELATED [EC:3.2.1.76]
xref: EC:3.2.1.76
xref: MetaCyc:3.2.1.76-RXN
xref: Reactome:R-HSA-1678716 "IDUA hydrolyses Heparan sulfate chain(1)"
xref: Reactome:R-HSA-1793186 "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS"
xref: Reactome:R-HSA-2090037 "IDUA hydrolyses Heparan sulfate chain(6)"
xref: Reactome:R-HSA-2206299 "Defective IDUA does not hydrolyse Heparan sulfate chain(6)"
xref: Reactome:R-HSA-9036037 "Defective IDUA does not hydrolyse Heparan sulfate chain(1)"
xref: Reactome:R-HSA-9036041 "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0003941
name: L-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17]
synonym: "L-hydroxyaminoacid dehydratase activity" BROAD []
synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" RELATED [EC:4.3.1.17]
synonym: "L-serine deaminase activity" EXACT []
synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17]
synonym: "L-serine dehydration activity" RELATED []
synonym: "L-serine hydro-lyase (deaminating) activity" EXACT []
synonym: "serine deaminase activity" BROAD [EC:4.3.1.17]
xref: EC:4.3.1.17
xref: MetaCyc:4.3.1.17-RXN
xref: RHEA:19169
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0003942
name: N-acetyl-gamma-glutamyl-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [RHEA:21588]
synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.38]
synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.38]
synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.38]
synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.38]
synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.38]
synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38]
synonym: "reductase, acetyl-gamma-glutamyl phosphate" RELATED [EC:1.2.1.38]
xref: EC:1.2.1.38
xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN
xref: RHEA:21588
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003943
name: N-acetylgalactosamine-4-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12]
synonym: "acetylgalactosamine 4-sulfatase activity" RELATED [EC:3.1.6.12]
synonym: "arylsulfatase B" EXACT []
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12]
synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" RELATED [EC:3.1.6.12]
synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.12]
synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT []
xref: EC:3.1.6.12
xref: MetaCyc:3.1.6.12-RXN
xref: Reactome:R-HSA-1606789 "ARSB hydrolyses DS"
xref: Reactome:R-HSA-1793207 "ARSB hydrolyses C4S/C6S chains"
xref: Reactome:R-HSA-2282889 "Defective ARSB does not hydrolyse C4S/C6S chains"
xref: Reactome:R-HSA-9036065 "Defective ARSB does not hydrolyse DS"
xref: Wikipedia:Arylsulfatase_B
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0003944
name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45]
synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" RELATED [EC:3.1.4.45]
synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" RELATED [EC:3.1.4.45]
synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" RELATED [EC:3.1.4.45]
synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" RELATED [EC:3.1.4.45]
synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45]
synonym: "phosphodiester glycosidase activity" RELATED [EC:3.1.4.45]
xref: EC:3.1.4.45
xref: MetaCyc:3.1.4.45-RXN
xref: RHEA:24372
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0003945
name: N-acetyllactosamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
synonym: "acetyllactosamine synthetase activity" RELATED [EC:2.4.1.90]
synonym: "beta-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "beta-1,4-GalT" RELATED [EC:2.4.1.90]
synonym: "beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "Gal-T" RELATED [EC:2.4.1.90]
synonym: "lactosamine synthase activity" RELATED [EC:2.4.1.90]
synonym: "lactosamine synthetase activity" RELATED [EC:2.4.1.90]
synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90]
synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "N-acetylglucosamine beta-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "N-acetyllactosamine synthetase activity" RELATED [EC:2.4.1.90]
synonym: "NAL synthetase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity" RELATED [EC:2.4.1.90]
synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" RELATED [EC:2.4.1.90]
xref: EC:2.4.1.90
xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN
xref: RHEA:17745
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003947
name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92]
synonym: "asialo-GM2 synthase activity" RELATED [EC:2.4.1.92]
synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "GalNAc-T activity" RELATED [EC:2.4.1.92]
synonym: "ganglioside GM2 synthase activity" RELATED [EC:2.4.1.92]
synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "GM2 synthase activity" RELATED [EC:2.4.1.92]
synonym: "GM2/GD2-synthase activity" RELATED [EC:2.4.1.92]
synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92]
xref: EC:2.4.1.92
xref: MetaCyc:2.4.1.92-RXN
xref: Reactome:R-HSA-8856223 "B4GALNT1 dimer transfers GalNAc to gangliosides"
xref: RHEA:12588
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0003948
name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+." [EC:3.5.1.26, RHEA:11544]
synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.26]
synonym: "aspartylglucosaminidase activity" RELATED [EC:3.5.1.26]
synonym: "aspartylglucosylaminase activity" RELATED [EC:3.5.1.26]
synonym: "aspartylglucosylamine deaspartylase activity" RELATED [EC:3.5.1.26]
synonym: "aspartylglucosylaminidase activity" RELATED [EC:3.5.1.26]
synonym: "aspartylglycosylamine amidohydrolase activity" RELATED [EC:3.5.1.26]
synonym: "beta-aspartylglucosylamine amidohydrolase activity" RELATED [EC:3.5.1.26]
synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26]
synonym: "glycosylasparaginase activity" RELATED [EC:3.5.1.26]
synonym: "N-aspartyl-beta-glucosaminidase activity" RELATED [EC:3.5.1.26]
synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.26]
xref: EC:3.5.1.26
xref: KEGG_REACTION:R03421
xref: MetaCyc:3.5.1.26-RXN
xref: RHEA:11544
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0003949
name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15469]
synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" RELATED [EC:5.3.1.16]
synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" RELATED [EC:5.3.1.16]
synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" RELATED [EC:5.3.1.16]
synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" RELATED [EC:5.3.1.16]
synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" RELATED [EC:5.3.1.16]
synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" RELATED [EC:5.3.1.16]
xref: EC:5.3.1.16
xref: KEGG_REACTION:R04640
xref: MetaCyc:PRIBFAICARPISOM-RXN
xref: RHEA:15469
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0003950
name: NAD+-protein poly-ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
synonym: "ADP-ribosyltransferase (polymerizing) activity" RELATED [EC:2.4.2.30]
synonym: "NAD ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+ ADP-ribosyltransferase activity" BROAD []
synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" RELATED [EC:2.4.2.30]
synonym: "poly(adenosine diphosphate ribose) polymerase activity" RELATED [EC:2.4.2.30]
synonym: "poly(ADP-ribose) synthase activity" RELATED [EC:2.4.2.30]
synonym: "poly(ADP-ribose) synthetase activity" RELATED [EC:2.4.2.30]
synonym: "poly(ADP-ribose)polymerase activity" RELATED [EC:2.4.2.30]
xref: EC:2.4.2.30
xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4"
xref: Reactome:R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN"
xref: Reactome:R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate"
xref: Reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate"
xref: Reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD"
xref: Reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)"
xref: Reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN"
xref: Reactome:R-HSA-9686061 "Nucleoprotein is ADP-ribosylated"
xref: Reactome:R-HSA-9729279 "Nucleoprotein is ADP-ribosylated"
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0003951
name: NAD+ kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+." [RHEA:18629]
synonym: "ATP:NAD+ 2'-phosphotransferase activity" RELATED [EC:2.7.1.23]
synonym: "DPN kinase activity" RELATED [EC:2.7.1.23]
synonym: "NAD kinase activity" EXACT []
synonym: "NADK" RELATED [EC:2.7.1.23]
synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" RELATED [EC:2.7.1.23]
synonym: "nicotinamide adenine dinucleotide kinase activity" RELATED [EC:2.7.1.23]
xref: EC:2.7.1.23
xref: KEGG_REACTION:R00104
xref: MetaCyc:NAD-KIN-RXN
xref: Reactome:R-HSA-197198 "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+"
xref: Reactome:R-HSA-8955030 "NADK2 dimer phosphorylates NAD+ to NADP+"
xref: RHEA:18629
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0003952
name: NAD+ synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1]
synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" RELATED [EC:6.3.5.1]
synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" RELATED [EC:6.3.5.1]
synonym: "DPN synthetase activity" RELATED [EC:6.3.5.1]
synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT []
synonym: "NAD synthetase (glutamine-hydrolysing)" RELATED [EC:6.3.5.1]
synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.1]
synonym: "NAD+ synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.1]
synonym: "NAD+ synthetase (glutamine-hydrolyzing)" RELATED [EC:6.3.5.1]
synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" RELATED [EC:6.3.5.1]
xref: EC:6.3.5.1
xref: MetaCyc:NAD-SYNTH-GLN-RXN
xref: Reactome:R-HSA-197271 "NADSYN1 hexamer amidates NAAD to NAD+"
xref: RHEA:24384
xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0003953
name: NAD+ nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]
synonym: "beta-NAD(+) glycohydrolase activity" EXACT []
synonym: "diphosphopyridine nucleosidase activity" EXACT []
synonym: "DPNase activity" EXACT []
synonym: "NAD glycohydrolase activity" EXACT []
synonym: "NAD nucleosidase activity" EXACT []
synonym: "NAD(+) glycohydrolase activity" EXACT []
synonym: "NADase activity" EXACT []
synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT []
synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT []
xref: EC:3.2.2.5
xref: MetaCyc:RXN-13859
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0003954
name: NADH dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [RHEA:11356]
synonym: "beta-NADH dehydrogenase dinucleotide activity" RELATED []
synonym: "cytochrome c reductase activity" RELATED []
synonym: "diaphorase activity" BROAD []
synonym: "dihydrocodehydrogenase I dehydrogenase activity" RELATED []
synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" RELATED []
synonym: "diphosphopyridine diaphorase activity" RELATED []
synonym: "diphosphopyrinase activity" RELATED []
synonym: "DPNH diaphorase activity" RELATED []
synonym: "NADH diaphorase activity" RELATED []
synonym: "NADH hydrogenase activity" RELATED []
synonym: "NADH oxidoreductase activity" RELATED []
synonym: "NADH-menadione oxidoreductase activity" NARROW []
synonym: "NADH2 dehydrogenase activity" RELATED []
synonym: "NADH:(acceptor) oxidoreductase activity" RELATED []
synonym: "NADH:acceptor oxidoreductase activity" RELATED []
synonym: "NADH:cytochrome c oxidoreductase activity" NARROW []
synonym: "reduced diphosphopyridine nucleotide diaphorase activity" RELATED []
synonym: "type 1 dehydrogenase activity" RELATED []
synonym: "type I dehydrogenase activity" RELATED []
xref: RHEA:11356
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0003955
name: NAD(P)H dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol." [EC:1.6.5.2]
synonym: "azoreductase activity" BROAD [EC:1.6.5.2]
synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" RELATED [EC:1.6.5.2]
synonym: "diaphorase activity" BROAD [EC:1.6.5.2]
synonym: "DT-diaphorase activity" RELATED [EC:1.6.5.2]
synonym: "flavoprotein NAD(P)H-quinone reductase activity" RELATED [EC:1.6.5.2]
synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2]
synonym: "menadione reductase activity" NARROW [EC:1.6.5.2]
synonym: "NAD(P)H dehydrogenase activity" BROAD []
synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2]
synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" RELATED [EC:1.6.5.2]
synonym: "NAD(P)H-quinone dehydrogenase activity" RELATED [EC:1.6.5.2]
synonym: "NAD(P)H-quinone oxidoreductase activity" RELATED [EC:1.6.5.2]
synonym: "NAD(P)H2 dehydrogenase (quinone)" RELATED [EC:1.6.5.2]
synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2]
synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" RELATED [EC:1.6.5.2]
synonym: "NAD(P)H:quinone oxidoreductase activity" RELATED [EC:1.6.5.2]
synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2]
synonym: "naphthoquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "NQO1" RELATED []
synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "QR1" RELATED []
synonym: "quinone reductase activity" RELATED [EC:1.6.5.2]
synonym: "reduced NAD(P)H dehydrogenase activity" RELATED [EC:1.6.5.2]
synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" RELATED [EC:1.6.5.2]
synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2]
synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2]
synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2]
xref: EC:1.6.5.2
xref: MetaCyc:NQOR-RXN
xref: UM-BBD_reactionID:r0227
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0003957
name: NAD(P)+ transhydrogenase (Si-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + NAD+ = NADP+ + NADH." [RHEA:11692]
synonym: "H+-thase" BROAD [EC:1.6.1.1]
synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT []
synonym: "NAD(P)+ transhydrogenase (B-specific) activity" EXACT []
synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1]
synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADPH:NAD+ oxidoreductase (B-specific)" RELATED [EC:1.6.1.1]
synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1]
synonym: "non-energy-linked transhydrogenase activity" RELATED [EC:1.6.1.1]
synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1]
synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1]
xref: EC:1.6.1.1
xref: Reactome:R-HSA-450971 "NNT dimer transfers proton from NADPH to NAD+"
xref: RHEA:11692
is_a: GO:0016652 ! oxidoreductase activity, acting on NAD(P)H as acceptor

[Term]
id: GO:0003958
name: NADPH-hemoprotein reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4]
synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4]
synonym: "CPR activity" RELATED [EC:1.6.2.4]
synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4]
synonym: "cytochrome P-450 reductase activity" RELATED [EC:1.6.2.4]
synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4]
synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4]
synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH-cytochrome P-450 oxidoreductase activity" RELATED [EC:1.6.2.4]
synonym: "NADPH-cytochrome p-450 reductase activity" RELATED [EC:1.6.2.4]
synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH-ferrihemoprotein reductase activity" EXACT []
synonym: "NADPH:cytochrome c reductase activity" EXACT []
synonym: "NADPH:cytochrome P450 reductase activity" EXACT []
synonym: "NADPH:ferrihemoprotein oxidoreductase activity" RELATED [EC:1.6.2.4]
synonym: "NADPH:hemoprotein oxidoreductase activity" RELATED [EC:1.6.2.4]
synonym: "NADPH:P-450 reductase activity" RELATED [EC:1.6.2.4]
synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "POR" RELATED [EC:1.6.2.4]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4]
synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "TPNH2 cytochrome c reductase activity" RELATED [EC:1.6.2.4]
xref: EC:1.6.2.4
xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
xref: Reactome:R-HSA-76494 "POR reduces CYP450:Fe3+ to CYP450:Fe2+"
xref: RHEA:24040
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0003959
name: NADPH dehydrogenase activity
namespace: molecular_function
alt_id: GO:0008468
alt_id: GO:0016660
def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [RHEA:13149]
synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" RELATED [EC:1.6.99.1]
synonym: "NADPH diaphorase activity" RELATED [EC:1.6.99.1]
synonym: "NADPH-dehydrogenase activity" RELATED [EC:1.6.99.1]
synonym: "NADPH2 diaphorase activity" RELATED [EC:1.6.99.1]
synonym: "NADPH2-dehydrogenase activity" RELATED [EC:1.6.99.1]
synonym: "NADPH:(acceptor) oxidoreductase activity" RELATED [EC:1.6.99.1]
synonym: "NADPH:acceptor oxidoreductase activity" RELATED [EC:1.6.99.1]
synonym: "old yellow enzyme" RELATED [EC:1.6.99.1]
synonym: "OYE" RELATED [EC:1.6.99.1]
synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" RELATED [EC:1.6.99.1]
synonym: "TPNH dehydrogenase activity" RELATED [EC:1.6.99.1]
synonym: "TPNH-diaphorase activity" RELATED [EC:1.6.99.1]
synonym: "triphosphopyridine diaphorase activity" RELATED [EC:1.6.99.1]
synonym: "triphosphopyridine nucleotide diaphorase activity" RELATED [EC:1.6.99.1]
xref: EC:1.6.99.1
xref: MetaCyc:NADPH-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-9018867 "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2"
xref: Reactome:R-HSA-9018901 "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HEPE to 18(R)-RvE2"
xref: RHEA:13149
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0003960
name: NADPH:quinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
synonym: "NADPH:quinone oxidoreductase activity" RELATED [EC:1.6.5.5]
synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5]
synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5]
xref: EC:1.6.5.5
xref: MetaCyc:QOR-RXN
xref: Reactome:R-HSA-6799722 "TP53I3 oxidoreductase generates unstable semiquinones"
xref: RHEA:14269
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0003961
name: O-acetylhomoserine aminocarboxypropyltransferase activity
namespace: molecular_function
alt_id: GO:0019282
def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers." [EC:2.5.1.49]
synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT []
synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" RELATED [EC:2.5.1.49]
synonym: "O-acetyl-L-homoserine sulfhydrolase activity" RELATED [EC:2.5.1.49]
synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" RELATED [EC:2.5.1.49]
synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT []
synonym: "O-acetylhomoserine sulfhydrolase activity" RELATED [EC:2.5.1.49]
synonym: "OAH sulfhydrylase activity" RELATED [EC:2.5.1.49]
xref: EC:2.5.1.49
xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003962
name: cystathionine gamma-synthase activity
namespace: molecular_function
alt_id: GO:0000505
def: "Catalysis of the reaction: L-cysteine + O-succinyl-L-homoserine = H+ + L,L-cystathionine + succinate." [RHEA:20397]
synonym: "CTT gamma synthase activity" EXACT []
synonym: "cystathionine g-synthase activity" EXACT []
synonym: "cystathionine gamma synthase activity" EXACT []
synonym: "cystathionine gamma-synthase activity (acts on O-phosphohomoserine)" NARROW []
synonym: "cystathionine synthase activity" RELATED [EC:2.5.1.48]
synonym: "cystathionine synthetase activity" RELATED [EC:2.5.1.48]
synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48]
synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48]
synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT []
synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" RELATED [EC:2.5.1.48]
synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT []
synonym: "O-succinylhomoserine (thiol)-lyase activity" RELATED [EC:2.5.1.48]
synonym: "O-succinylhomoserine synthase activity" RELATED [EC:2.5.1.48]
synonym: "O-succinylhomoserine synthetase activity" RELATED [EC:2.5.1.48]
synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" RELATED [EC:2.5.1.48]
xref: EC:2.5.1.48
xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN
xref: RHEA:20397
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003963
name: RNA-3'-phosphate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4]
synonym: "RNA 3'-terminal phosphate cyclase activity" RELATED [EC:6.5.1.4]
synonym: "RNA cyclase activity" RELATED [EC:6.5.1.4]
synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" RELATED [EC:6.5.1.4]
xref: EC:6.5.1.4
xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN
xref: RHEA:23976
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0003964
name: RNA-directed DNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" RELATED [EC:2.7.7.49]
synonym: "DNA nucleotidyltransferase (RNA-directed) activity" RELATED [EC:2.7.7.49]
synonym: "reverse transcriptase activity" RELATED [EC:2.7.7.49]
synonym: "revertase activity" RELATED [EC:2.7.7.49]
synonym: "RNA revertase activity" RELATED [EC:2.7.7.49]
synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.49]
synonym: "RNA-dependent DNA polymerase activity" RELATED [EC:2.7.7.49]
synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW []
synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW []
synonym: "RNA-instructed DNA polymerase activity" RELATED [EC:2.7.7.49]
synonym: "RT" RELATED [EC:2.7.7.49]
xref: EC:2.7.7.49
xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN
xref: Reactome:R-HSA-164504 "Synthesis of minus strand strong stop DNA (-sssDNA)"
xref: Reactome:R-HSA-164520 "Minus strand DNA synthesis resumes"
is_a: GO:0034061 ! DNA polymerase activity

[Term]
id: GO:0003966
name: obsolete RNA-directed DNA polymerase, transposon encoded
namespace: molecular_function
def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49]
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
synonym: "RNA-directed DNA polymerase, transposon encoded" EXACT []
is_obsolete: true
replaced_by: GO:0003964

[Term]
id: GO:0003967
name: obsolete RNA-directed DNA polymerase, group II intron encoded
namespace: molecular_function
def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49]
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
synonym: "RNA-directed DNA polymerase, group II intron encoded" EXACT []
is_obsolete: true
replaced_by: GO:0003964

[Term]
id: GO:0003968
name: RNA-dependent RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]
synonym: "RdRP activity" EXACT []
synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT []
synonym: "RNA replicase activity" RELATED []
synonym: "RNA synthetase activity" RELATED []
synonym: "RNA-dependent RNA replicase activity" EXACT []
synonym: "RNA-directed 5'-3' RNA polymerase activity" EXACT []
synonym: "RNA-directed RNA polymerase activity" EXACT []
synonym: "transcriptase" BROAD []
xref: EC:2.7.7.48
xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN
xref: Reactome:R-HSA-168280 "Priming and Initiation of Transcription"
xref: Reactome:R-HSA-168301 "Elongation, Polyadenylation and Termination"
xref: Reactome:R-HSA-192624 "cRNA Extension"
xref: Reactome:R-HSA-192832 "Initiation of cRNA Synthesis"
xref: Reactome:R-HSA-192851 "vRNA Extension"
xref: Reactome:R-HSA-192916 "Initiation of vRNA Synthesis"
xref: Reactome:R-HSA-9681651 "nsp8 generates RNA primers"
xref: Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement"
xref: Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA"
xref: Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement"
xref: Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand"
xref: Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching"
xref: Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs"
xref: Reactome:R-HSA-9694277 "nsp8 generates RNA primers"
xref: Reactome:R-HSA-9694344 "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching"
xref: Reactome:R-HSA-9694506 "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs"
xref: Reactome:R-HSA-9694549 "RTC completes synthesis of the minus strand genomic RNA complement"
xref: Reactome:R-HSA-9694581 "RTC synthesizes SARS-CoV-2 plus strand genomic RNA"
xref: Reactome:R-HSA-9694605 "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement"
xref: Reactome:R-HSA-9694792 "nsp12 misincorporates a nucleotide in nascent RNA minus strand"
xref: Reactome:R-HSA-9828639 "Transcription of respiratory syncytial virus subgenomic positive sense mRNAs"
xref: Reactome:R-HSA-9834719 "Synthesis of negative sense genomic RNA of respiratory syncytial virus"
xref: Reactome:R-HSA-9834736 "Synthesis of antigenomic RNA of human respiratory syncytial virus"
xref: Reactome:R-HSA-9837511 "Abortive replication of hRSV A"
is_a: GO:0034062 ! 5'-3' RNA polymerase activity

[Term]
id: GO:0003969
name: obsolete RNA editase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a biological process.
synonym: "RNA editase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0003972
name: RNA ligase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate." [EC:6.5.1.3]
synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" RELATED [EC:6.5.1.3]
synonym: "polyribonucleotide ligase activity" RELATED [EC:6.5.1.3]
synonym: "polyribonucleotide synthase (ATP) activity" RELATED [EC:6.5.1.3]
synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3]
xref: EC:6.5.1.3
xref: MetaCyc:RNA-LIGASE-ATP-RXN
xref: Reactome:R-HSA-5696816 "tRNA ligase complex ligates tRNA exons"
is_a: GO:0008452 ! RNA ligase activity

[Term]
id: GO:0003973
name: (S)-2-hydroxy-acid oxidase activity
namespace: molecular_function
alt_id: GO:0008891
alt_id: GO:0052852
alt_id: GO:0052853
alt_id: GO:0052854
def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [RHEA:16789]
synonym: "glycolate oxidase activity" RELATED []
synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15]
synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15]
synonym: "hydroxyacid oxidase A" RELATED []
synonym: "L-2-hydroxy acid oxidase" RELATED []
synonym: "L-alpha-hydroxy acid oxidase" RELATED []
synonym: "long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity" NARROW []
synonym: "medium-chain-(S)-2-hydroxy-acid oxidase activity" NARROW []
synonym: "very-long-chain-(S)-2-hydroxy-acid oxidase activity" NARROW []
xref: EC:1.1.3.15
xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN
xref: Reactome:R-HSA-389842 "HAO1 tetramer oxidizes glycolate to glyoxylate"
xref: Reactome:R-HSA-6787811 "HAO2 tetramer oxidises 2OH-PALM"
xref: RHEA:16789
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0003974
name: UDP-N-acetylglucosamine 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "UDP acetylglucosamine epimerase activity" RELATED [EC:5.1.3.7]
synonym: "UDP-GlcNAc 4-epimerase activity" RELATED [EC:5.1.3.7]
synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" RELATED [EC:5.1.3.7]
synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" RELATED [EC:5.1.3.7]
synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" RELATED [EC:5.1.3.7]
synonym: "uridine diphosphoacetylglucosamine epimerase activity" RELATED [EC:5.1.3.7]
xref: EC:5.1.3.7
xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN
xref: RHEA:20517
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0003975
name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15]
synonym: "chitobiosylpyrophosphoryldolichol synthase activity" RELATED [EC:2.7.8.15]
synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.15]
synonym: "GlcNAc-1-P transferase activity" RELATED [EC:2.7.8.15]
synonym: "N-acetylglucosamine-1-phosphate transferase activity" RELATED [EC:2.7.8.15]
synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" RELATED [EC:2.7.8.15]
synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.15]
synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" RELATED [EC:2.7.8.15]
synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" RELATED [EC:2.7.8.15]
synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" RELATED [EC:2.7.8.15]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" RELATED [EC:2.7.8.15]
synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT []
synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.15]
xref: EC:2.7.8.15
xref: MetaCyc:2.7.8.15-RXN
xref: Reactome:R-HSA-446191 "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate"
xref: Reactome:R-HSA-4549334 "Defective DPAGT1 does not transfer GlcNAc to DOLP"
xref: RHEA:13289
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0003976
name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17]
synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "N-acetylglucosaminyl phosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17]
xref: EC:2.7.8.17
xref: MetaCyc:2.7.8.17-RXN
xref: RHEA:13581
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0003977
name: UDP-N-acetylglucosamine diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13509]
synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23]
synonym: "GlmU uridylyltransferase activity" RELATED [EC:2.7.7.23]
synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" RELATED [EC:2.7.7.23]
synonym: "UDP-acetylglucosamine pyrophosphorylase activity" RELATED [EC:2.7.7.23]
synonym: "UDP-GlcNAc pyrophosphorylase activity" RELATED [EC:2.7.7.23]
synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT []
synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" RELATED [EC:2.7.7.23]
synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" RELATED [EC:2.7.7.23]
synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" RELATED [EC:2.7.7.23]
synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.23]
synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.23]
xref: EC:2.7.7.23
xref: KEGG_REACTION:R00416
xref: MetaCyc:NAG1P-URIDYLTRANS-RXN
xref: Reactome:R-HSA-446204 "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine"
xref: RHEA:13509
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0003978
name: UDP-glucose 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]
synonym: "4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2]
synonym: "UDP-D-galactose 4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "UDP-galactose 4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "UDP-glucose epimerase activity" RELATED [EC:5.1.3.2]
synonym: "UDPG-4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "UDPgalactose 4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "UDPglucose 4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "uridine diphosphate galactose 4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "uridine diphosphate glucose 4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "uridine diphospho-galactose-4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "uridine diphosphoglucose 4-epimerase activity" RELATED [EC:5.1.3.2]
synonym: "uridine diphosphoglucose epimerase activity" RELATED [EC:5.1.3.2]
xref: EC:5.1.3.2
xref: MetaCyc:UDPGLUCEPIM-RXN
xref: Reactome:R-HSA-5610036 "Defective GALE does not epimerise UDP-Gal to UDP-Glc"
xref: Reactome:R-HSA-70369 "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc"
xref: RHEA:22168
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0003979
name: UDP-glucose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596]
xref: EC:1.1.1.22
xref: KEGG_REACTION:R00286
xref: MetaCyc:UGD-RXN
xref: Reactome:R-HSA-173597 "UDP-glucose is oxidised to UDP-glucuronate"
xref: RHEA:23596
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003980
name: UDP-glucose:glycoprotein glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828]
synonym: "UGGT activity" EXACT []
xref: Reactome:R-HSA-548884 "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b"
xref: RHEA:61304
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003983
name: UTP:glucose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19889]
synonym: "glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.9]
synonym: "UDP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "UDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "UDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "UDPG phosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "UDPG pyrophosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "uridine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "uridine-diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9]
synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.9]
synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.9]
xref: EC:2.7.7.9
xref: KEGG_REACTION:R00289
xref: MetaCyc:GLUC1PURIDYLTRANS-RXN
xref: Reactome:R-HSA-70286 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose"
xref: RHEA:19889
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0003984
name: acetolactate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate." [EC:2.2.1.6]
synonym: "acetohydroxy acid synthetase activity" RELATED [EC:2.2.1.6]
synonym: "acetohydroxyacid synthase activity" RELATED [EC:2.2.1.6]
synonym: "acetolactate pyruvate-lyase (carboxylating) activity" RELATED [EC:2.2.1.6]
synonym: "acetolactic synthetase activity" RELATED [EC:2.2.1.6]
synonym: "alpha-acetohydroxy acid synthetase activity" RELATED [EC:2.2.1.6]
synonym: "alpha-acetohydroxyacid synthase activity" RELATED [EC:2.2.1.6]
synonym: "alpha-acetolactate synthase activity" RELATED [EC:2.2.1.6]
synonym: "alpha-acetolactate synthetase activity" RELATED [EC:2.2.1.6]
synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" RELATED [EC:2.2.1.6]
xref: EC:2.2.1.6
xref: MetaCyc:ACETOLACTSYN-RXN
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0003985
name: acetyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [RHEA:21036]
synonym: "acetoacetyl-CoA thiolase activity" RELATED [EC:2.3.1.9]
synonym: "acetyl coenzyme A thiolase activity" RELATED []
xref: EC:2.3.1.9
xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN
xref: Reactome:R-HSA-70844 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA"
xref: Reactome:R-HSA-73916 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA"
xref: Reactome:R-HSA-74181 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA"
xref: Reactome:R-HSA-8848215 "ACAT2 condenses 2 Ac-CoA to form ACA-CoA"
xref: Reactome:R-HSA-9915356 "ACAT1 mutants don't synthesize propionyl-CoA or acetyl-CoA"
xref: RHEA:21036
xref: UM-BBD_reactionID:r0201
is_a: GO:0003988 ! acetyl-CoA C-acyltransferase activity
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0003986
name: acetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+." [EC:3.1.2.1, RHEA:20289]
synonym: "acetyl coenzyme A acylase activity" RELATED [EC:3.1.2.1]
synonym: "acetyl coenzyme A deacylase activity" RELATED [EC:3.1.2.1]
synonym: "acetyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.1]
synonym: "acetyl-CoA acylase activity" RELATED [EC:3.1.2.1]
synonym: "acetyl-CoA deacylase activity" RELATED [EC:3.1.2.1]
synonym: "acetyl-CoA thiol esterase activity" RELATED [EC:3.1.2.1]
xref: EC:3.1.2.1
xref: KEGG_REACTION:R00227
xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN
xref: Reactome:R-HSA-2066779 "Conversion of DHA-CoA to docosahexaenoic acid (DHA)"
xref: Reactome:R-HSA-390304 "acetyl-CoA + H2O => acetate + CoASH + H+"
xref: RHEA:20289
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0003987
name: acetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1]
synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1]
synonym: "acetate to acetyl-CoA" RELATED []
synonym: "acetate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.1]
synonym: "acetic thiokinase activity" RELATED [EC:6.2.1.1]
synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1]
synonym: "acetyl CoA ligase activity" RELATED [EC:6.2.1.1]
synonym: "acetyl CoA synthase activity" RELATED [EC:6.2.1.1]
synonym: "acetyl coenzyme A synthetase activity" RELATED [EC:6.2.1.1]
synonym: "acetyl-activating enzyme activity" RELATED [EC:6.2.1.1]
synonym: "acetyl-CoA synthase activity" RELATED [EC:6.2.1.1]
synonym: "acetyl-CoA synthetase activity" RELATED [EC:6.2.1.1]
synonym: "acetyl-coenzyme A synthase activity" RELATED [EC:6.2.1.1]
synonym: "ACS" RELATED [EC:6.2.1.1]
synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1]
synonym: "short chain fatty acyl-CoA synthetase activity" RELATED [EC:6.2.1.1]
synonym: "short-chain acyl-coenzyme A synthetase activity" RELATED [EC:6.2.1.1]
xref: EC:6.2.1.1
xref: MetaCyc:ACETATE--COA-LIGASE-RXN
xref: Reactome:R-HSA-449911 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]"
xref: Reactome:R-HSA-71735 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]"
xref: Reactome:R-HSA-8875071 "ACSS3 ligates CoA to CH3COO-"
xref: RHEA:23176
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0003988
name: acetyl-CoA C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [RHEA:21564]
synonym: "2-keto-acyl thiolase activity" EXACT []
synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT []
synonym: "3-ketoacyl-CoA thiolase activity" EXACT []
synonym: "3-ketothiolase activity" EXACT []
synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT []
synonym: "acetyl-CoA acyltransferase activity" EXACT []
synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT []
synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16]
xref: EC:2.3.1.16
xref: MetaCyc:KETOACYLCOATHIOL-RXN
xref: Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA"
xref: Reactome:R-HSA-77271 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA"
xref: Reactome:R-HSA-77304 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA"
xref: Reactome:R-HSA-77309 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA"
xref: Reactome:R-HSA-77321 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA"
xref: Reactome:R-HSA-77329 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA"
xref: Reactome:R-HSA-77340 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA"
xref: Reactome:R-HSA-8874745 "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH"
xref: RHEA:21564
xref: UM-BBD_reactionID:r1051
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0003989
name: acetyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
synonym: "acetyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.2]
synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.2]
xref: EC:6.4.1.2
xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN
xref: Reactome:R-HSA-200555 "Formation of Malonyl-CoA from Acetyl-CoA (liver)"
xref: Reactome:R-HSA-75851 "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA"
xref: Reactome:R-HSA-8876889 "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA"
xref: RHEA:11308
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0003990
name: acetylcholinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
subset: goslim_chembl
synonym: "AcCholE" RELATED [EC:3.1.1.7]
synonym: "acetyl.beta-methylcholinesterase activity" RELATED [EC:3.1.1.7]
synonym: "acetylcholine acetylhydrolase activity" RELATED [EC:3.1.1.7]
synonym: "acetylcholine hydrolase activity" RELATED [EC:3.1.1.7]
synonym: "acetylthiocholinesterase activity" RELATED [EC:3.1.1.7]
synonym: "choline esterase I activity" RELATED [EC:3.1.1.7]
synonym: "true cholinesterase activity" RELATED [EC:3.1.1.7]
xref: EC:3.1.1.7
xref: MetaCyc:ACETYLCHOLINESTERASE-RXN
xref: Reactome:R-HSA-372519 "AcCho is hydrolyzed to Cho and acetate by ACHE"
xref: RHEA:17561
is_a: GO:0004104 ! cholinesterase activity

[Term]
id: GO:0003991
name: acetylglutamate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8]
synonym: "acetylglutamate phosphokinase activity" RELATED [EC:2.7.2.8]
synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.8]
synonym: "N-acetylglutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.8]
synonym: "N-acetylglutamate kinase activity" RELATED [EC:2.7.2.8]
synonym: "N-acetylglutamate phosphokinase activity" RELATED [EC:2.7.2.8]
synonym: "N-acetylglutamic 5-phosphotransferase activity" RELATED [EC:2.7.2.8]
xref: EC:2.7.2.8
xref: MetaCyc:ACETYLGLUTKIN-RXN
xref: RHEA:14629
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0003992
name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
namespace: molecular_function
alt_id: GO:0047318
def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18049]
synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" RELATED [EC:2.6.1.11]
synonym: "acetylornithine 5-aminotransferase activity" RELATED [EC:2.6.1.11]
synonym: "acetylornithine aminotransferase activity" BROAD []
synonym: "acetylornithine delta-transaminase activity" RELATED [EC:2.6.1.11]
synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11]
synonym: "ACOAT activity" RELATED [EC:2.6.1.11]
synonym: "N(2)-acetylornithine 5-transaminase activity" RELATED [EC:2.6.1.11]
synonym: "N-acetylornithine aminotransferase activity" RELATED [EC:2.6.1.11]
synonym: "N-acetylornithine-delta-transaminase activity" RELATED [EC:2.6.1.11]
synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.11]
synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT []
synonym: "N2-acetylornithine 5-transaminase activity" RELATED [EC:2.6.1.11]
synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11]
xref: EC:2.6.1.11
xref: KEGG_REACTION:R02283
xref: MetaCyc:ACETYLORNTRANSAM-RXN
xref: RHEA:18049
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0003993
name: acid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
synonym: "acid monophosphatase activity" RELATED [EC:3.1.3.2]
synonym: "acid nucleoside diphosphate phosphatase activity" RELATED [EC:3.1.3.2]
synonym: "acid phosphohydrolase activity" RELATED [EC:3.1.3.2]
synonym: "acid phosphomonoester hydrolase activity" RELATED [EC:3.1.3.2]
synonym: "acid phosphomonoesterase activity" RELATED [EC:3.1.3.2]
synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2]
synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" RELATED [EC:3.1.3.2]
synonym: "phosphate-monoester phosphohydrolase (acid optimum)" RELATED [EC:3.1.3.2]
synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2]
synonym: "uteroferrin" RELATED [EC:3.1.3.2]
xref: EC:3.1.3.2
xref: MetaCyc:ACID-PHOSPHATASE-RXN
xref: Reactome:R-HSA-196950 "2xTRAP hydrolyzes FMN to RIB"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0003994
name: aconitate hydratase activity
namespace: molecular_function
alt_id: GO:0052632
def: "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]
synonym: "aconitase activity" EXACT []
synonym: "cis-aconitase activity" RELATED [EC:4.2.1.3]
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" RELATED [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase activity" RELATED [EC:4.2.1.3]
xref: EC:4.2.1.3
xref: MetaCyc:RXN-14047
xref: Reactome:R-HSA-5690911 "ACO1:4Fe-4S isomerises CIT to ISCIT"
xref: Reactome:R-HSA-70971 "ACO2 isomerizes citrate"
xref: RHEA:10336
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003995
name: acyl-CoA dehydrogenase activity
namespace: molecular_function
alt_id: GO:0019109
def: "Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]
synonym: "acyl CoA dehydrogenase activity" EXACT []
synonym: "acyl coenzyme A dehydrogenase activity" EXACT []
synonym: "acyl-CoA reductase activity" EXACT []
synonym: "fatty acyl coenzyme A dehydrogenase activity" RELATED []
synonym: "fatty-acyl-CoA dehydrogenase activity" RELATED []
synonym: "general acyl CoA dehydrogenase activity" RELATED []
xref: MetaCyc:ACYLCOADEHYDROG-RXN
xref: Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA"
xref: Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA"
xref: Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2"
xref: Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2"
xref: Reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2"
xref: Reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2"
xref: Reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2"
xref: Reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2"
xref: Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2"
xref: Reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2"
xref: Reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2"
xref: RHEA:44704
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

[Term]
id: GO:0003997
name: acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2." [RHEA:38959]
synonym: "acyl coenzyme A oxidase activity" RELATED [EC:1.3.3.6]
synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" RELATED [EC:1.3.3.6]
synonym: "fatty acyl-CoA oxidase activity" RELATED [EC:1.3.3.6]
synonym: "fatty acyl-coenzyme A oxidase activity" RELATED [EC:1.3.3.6]
xref: EC:1.3.3.6
xref: MetaCyc:RXN-11026
xref: Reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)"
xref: Reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA"
xref: Reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA"
xref: Reactome:R-HSA-390256 "ACOX1 oxidizes C26:0 CoA"
xref: RHEA:38959
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0003998
name: acylphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7]
synonym: "1,3-diphosphoglycerate phosphatase activity" RELATED [EC:3.6.1.7]
synonym: "acetic phosphatase activity" RELATED [EC:3.6.1.7]
synonym: "acetylphosphatase activity" RELATED [EC:3.6.1.7]
synonym: "acylphosphate phosphohydrolase activity" RELATED [EC:3.6.1.7]
synonym: "GP 1-3" RELATED [EC:3.6.1.7]
synonym: "Ho 1-3" RELATED [EC:3.6.1.7]
xref: EC:3.6.1.7
xref: MetaCyc:ACYLPHOSPHATASE-RXN
xref: RHEA:14965
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0003999
name: adenine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [RHEA:16609]
synonym: "adenine phosphoribosylpyrophosphate transferase activity" RELATED [EC:2.4.2.7]
synonym: "adenosine phosphoribosyltransferase activity" RELATED [EC:2.4.2.7]
synonym: "adenylate pyrophosphorylase activity" RELATED [EC:2.4.2.7]
synonym: "adenylic pyrophosphorylase activity" RELATED [EC:2.4.2.7]
synonym: "AMP diphosphorylase activity" RELATED [EC:2.4.2.7]
synonym: "AMP pyrophosphorylase activity" RELATED [EC:2.4.2.7]
synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.7]
synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.7]
synonym: "APRT activity" RELATED [EC:2.4.2.7]
synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7]
xref: EC:2.4.2.7
xref: MetaCyc:ADENPRIBOSYLTRAN-RXN
xref: Reactome:R-HSA-74213 "APRT catalyzes the conversion of adenine to AMP"
xref: Reactome:R-HSA-9734193 "Defective APRT does not convert adenine to AMP"
xref: RHEA:16609
is_a: GO:0106130 ! purine phosphoribosyltransferase activity

[Term]
id: GO:0004000
name: adenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [RHEA:24408]
synonym: "adenosine aminohydrolase activity" RELATED [EC:3.5.4.4]
synonym: "adenosine deaminase reaction" EXACT []
xref: MetaCyc:ADENODEAMIN-RXN
xref: Reactome:R-HSA-5693346 "CECRI deaminates Ade-Rib to Ino"
xref: RHEA:24408
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004001
name: adenosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943]
synonym: "adenosine 5-phosphotransferase activity" EXACT []
synonym: "adenosine kinase (phosphorylating)" RELATED [EC:2.7.1.20]
synonym: "ATP:adenosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.20]
xref: EC:2.7.1.20
xref: MetaCyc:ADENOSINE-KINASE-RXN
xref: Reactome:R-HSA-109624 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)"
xref: Reactome:R-HSA-9754974 "ADK phosphorylates RBV"
xref: RHEA:20824
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0004005
name: obsolete plasma membrane cation-transporting ATPase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "plasma membrane cation-transporting ATPase" EXACT []
is_obsolete: true
consider: GO:0005886
consider: GO:0019829

[Term]
id: GO:0004007
name: obsolete heavy metal-exporting ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal-exporting ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046873

[Term]
id: GO:0004009
name: obsolete ATP-binding cassette (ABC) transporter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ATP-binding cassette (ABC) transporter activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0004013
name: adenosylhomocysteinase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [RHEA:21708]
subset: goslim_chembl
synonym: "adenosylhomocysteine hydrolase activity" RELATED []
synonym: "AdoHcyase activity" RELATED []
synonym: "S-adenosyl-L-homocysteine hydrolase activity" RELATED []
synonym: "S-adenosylhomocysteinase activity" RELATED []
synonym: "S-adenosylhomocysteine hydrolase activity" BROAD []
synonym: "S-adenosylhomocysteine synthase activity" RELATED []
synonym: "SAHase activity" RELATED []
xref: EC:3.13.2.1
xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN
xref: Reactome:R-HSA-174401 "AHCY:NAD+ tetramer hydrolyses AdoHcy"
xref: Reactome:R-HSA-5579084 "Defective AHCY does not hydrolyse AdoHcy"
xref: RHEA:21708
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0004014
name: adenosylmethionine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2." [EC:4.1.1.50, RHEA:15981]
synonym: "adenosyl methionine decarboxylase activity" EXACT []
synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50]
synonym: "S-adenosyl-L-methionine carboxy-lyase activity" RELATED [EC:4.1.1.50]
synonym: "S-adenosyl-L-methionine decarboxylase activity" RELATED [EC:4.1.1.50]
synonym: "S-adenosylmethionine decarboxylase activity" RELATED [EC:4.1.1.50]
xref: EC:4.1.1.50
xref: KEGG_REACTION:R00178
xref: MetaCyc:SAMDECARB-RXN
xref: Reactome:R-HSA-351222 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2"
xref: RHEA:15981
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004015
name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16861]
synonym: "7,8-diamino-pelargonic acid aminotransferase activity" RELATED [EC:2.6.1.62]
synonym: "7,8-diaminonanoate transaminase activity" RELATED [EC:2.6.1.62]
synonym: "7,8-diaminononanoate aminotransferase activity" RELATED [EC:2.6.1.62]
synonym: "7,8-diaminononanoate transaminase activity" RELATED [EC:2.6.1.62]
synonym: "7,8-diaminopelargonic acid aminotransferase activity" RELATED [EC:2.6.1.62]
synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62]
synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" RELATED [EC:2.6.1.62]
synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT []
synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" RELATED [EC:2.6.1.62]
synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT []
synonym: "DAPA aminotransferase activity" RELATED [EC:2.6.1.62]
synonym: "DAPA transaminase activity" RELATED [EC:2.6.1.62]
synonym: "diaminopelargonate synthase activity" RELATED [EC:2.6.1.62]
synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" RELATED [EC:2.6.1.62]
xref: EC:2.6.1.62
xref: KEGG_REACTION:R03231
xref: MetaCyc:DAPASYN-RXN
xref: RHEA:16861
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004016
name: adenylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
synonym: "3',5'-cyclic AMP synthetase activity" RELATED [EC:4.6.1.1]
synonym: "adenyl cyclase activity" RELATED [EC:4.6.1.1]
synonym: "adenylyl cyclase activity" EXACT []
synonym: "adenylylcyclase activity" RELATED [EC:4.6.1.1]
synonym: "ATP diphosphate-lyase (cyclizing) activity" RELATED [EC:4.6.1.1]
synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" RELATED [EC:4.6.1.1]
synonym: "ATP pyrophosphate-lyase activity" RELATED [EC:4.6.1.1]
synonym: "cAMP generating peptide activity" RELATED []
xref: EC:4.6.1.1
xref: MetaCyc:ADENYLATECYC-RXN
xref: Reactome:R-HSA-164377 "Activated Adenylate cyclase catalyses cAMP synthesis"
xref: Reactome:R-HSA-170676 "Adenylate cyclase converts ATP into cyclic AMP"
xref: Reactome:R-HSA-381607 "Activated Adenylyl cyclase synthesizes cyclic AMP"
xref: Reactome:R-HSA-392129 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate"
xref: Reactome:R-HSA-5211224 "Anthrax cya catalyzes the conversion of ATP to cAMP"
xref: Reactome:R-HSA-5610727 "GPR161 promotes cAMP production in a G alpha(s)-dependent manner"
xref: Reactome:R-HSA-9712183 "ADCY3:GNAL:GTP converts ATP to cAMP"
xref: RHEA:15389
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0004017
name: adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
synonym: "5'-AMP-kinase activity" RELATED [EC:2.7.4.3]
synonym: "adenylic kinase activity" RELATED [EC:2.7.4.3]
synonym: "adenylokinase activity" RELATED [EC:2.7.4.3]
synonym: "ATP:AMP phosphotransferase activity" RELATED [EC:2.7.4.3]
synonym: "myokinase activity" NARROW [EC:2.7.4.3]
xref: EC:2.7.4.3
xref: MetaCyc:ADENYL-KIN-RXN
xref: Reactome:R-HSA-110141 "(d)ADP + ADP <=> (d)AMP + ATP (AK1)"
xref: Reactome:R-HSA-110144 "ADP + ADP <=> AMP + ATP [AK2]"
xref: Reactome:R-HSA-110145 "AMP + ATP <=> ADP + ADP [AK2]"
xref: Reactome:R-HSA-74220 "(d)AMP + ATP <=> (d)ADP + ADP (AK1)"
xref: RHEA:12973
is_a: GO:0050145 ! nucleoside monophosphate kinase activity

[Term]
id: GO:0004018
name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [RHEA:16853]
synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" RELATED [EC:4.3.2.2]
synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah]
synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah]
synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" RELATED [EC:4.3.2.2]
synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah]
xref: KEGG_REACTION:R01083
xref: MetaCyc:AMPSYN-RXN
xref: RHEA:16853
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004019
name: adenylosuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate." [EC:6.3.4.4, RHEA:15753]
synonym: "adenylosuccinate synthetase activity" RELATED [EC:6.3.4.4]
synonym: "IMP--aspartate ligase activity" RELATED [EC:6.3.4.4]
synonym: "IMP:L-aspartate ligase (GDP-forming)" RELATED [EC:6.3.4.4]
synonym: "succino-AMP synthetase activity" RELATED [EC:6.3.4.4]
synonym: "succinoadenylic kinosynthetase activity" RELATED [EC:6.3.4.4]
xref: EC:6.3.4.4
xref: KEGG_REACTION:R01135
xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN
xref: Reactome:R-HSA-111524 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]"
xref: RHEA:15753
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004020
name: adenylylsulfate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H+." [EC:2.7.1.25]
synonym: "5'-phosphoadenosine sulfate kinase activity" RELATED [EC:2.7.1.25]
synonym: "adenosine 5'-phosphosulfate kinase activity" RELATED [EC:2.7.1.25]
synonym: "adenosine phosphosulfate kinase activity" RELATED [EC:2.7.1.25]
synonym: "adenosine phosphosulfokinase activity" RELATED [EC:2.7.1.25]
synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT []
synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" RELATED [EC:2.7.1.25]
synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT []
synonym: "adenylyl-sulfate kinase activity" EXACT []
synonym: "adenylyl-sulphate kinase activity" EXACT []
synonym: "adenylylsulfate kinase (phosphorylating)" RELATED [EC:2.7.1.25]
synonym: "APS kinase activity" RELATED [EC:2.7.1.25]
synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" RELATED [EC:2.7.1.25]
xref: EC:2.7.1.25
xref: MetaCyc:ADENYLYLSULFKIN-RXN
xref: Reactome:R-HSA-174389 "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS"
xref: Reactome:R-HSA-3560785 "Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS"
xref: RHEA:24152
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004021
name: L-alanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [RHEA:19453]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "alanine aminotransferase activity" BROAD []
synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2]
synonym: "alanine-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.2]
synonym: "alanine-pyruvate aminotransferase activity" RELATED [EC:2.6.1.2]
synonym: "ALT" RELATED [EC:2.6.1.2]
synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2]
synonym: "glutamic acid-pyruvic acid transaminase activity" RELATED [EC:2.6.1.2]
synonym: "glutamic--alanine transaminase activity" RELATED [EC:2.6.1.2]
synonym: "glutamic--pyruvic transaminase activity" RELATED [EC:2.6.1.2]
synonym: "glutamic-pyruvic aminotransferase activity" RELATED [EC:2.6.1.2]
synonym: "GPT" RELATED [EC:2.6.1.2]
synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2]
synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2]
synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.2]
synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2]
synonym: "pyruvate-alanine aminotransferase activity" RELATED [EC:2.6.1.2]
synonym: "pyruvate-glutamate transaminase activity" RELATED [EC:2.6.1.2]
xref: EC:2.6.1.2
xref: KEGG_REACTION:R00258
xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-507749 "PXLP-K341-GPT2 transaminates PYR to form L-Ala"
xref: Reactome:R-HSA-507775 "PXLP-K341-GPT2 transaminates L-Ala to form PYR"
xref: Reactome:R-HSA-70523 "PXLP-K314-GPT transaminates L-Ala to form PYR"
xref: Reactome:R-HSA-70524 "PXLP-K314-GPT transaminates PYR to form L-Ala"
xref: RHEA:19453
is_a: GO:0047635 ! alanine-oxo-acid transaminase activity

[Term]
id: GO:0004022
name: alcohol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
synonym: "ADH" RELATED [EC:1.1.1.1]
synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah]
synonym: "alcohol:NAD+ oxidoreductase" RELATED [EC:1.1.1.1]
synonym: "aldehyde dehydrogenase (NAD) activity" NARROW []
synonym: "aldo-keto reductase (NAD) activity" EXACT []
synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1]
synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1]
synonym: "NAD-dependent alcohol dehydrogenase" RELATED [EC:1.1.1.1]
synonym: "NAD-specific aromatic alcohol dehydrogenase" RELATED [EC:1.1.1.1]
synonym: "NADH-alcohol dehydrogenase" RELATED [EC:1.1.1.1]
synonym: "NADH-aldehyde dehydrogenase" RELATED [EC:1.1.1.1]
synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1]
synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1]
xref: EC:1.1.1.1
xref: Reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+"
xref: Reactome:R-HSA-71707 "ethanol + NAD+ => acetaldehyde + NADH + H+"
is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004023
name: obsolete alcohol dehydrogenase (NAD+) activity, metal ion-independent
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [GOC:mah]
comment: This term was obsoleted because it represents the same activity as alcohol dehydrogenase (NAD+) activity ; GO:0004022.
synonym: "alcohol dehydrogenase activity, metal ion-independent" BROAD []
is_obsolete: true
replaced_by: GO:0004022

[Term]
id: GO:0004024
name: obsolete alcohol dehydrogenase (NAD+) activity, zinc-dependent
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [GOC:mah]
comment: This term was obsoleted because it represents the same activity as alcohol dehydrogenase (NAD+) activity ; GO:0004022.
synonym: "alcohol dehydrogenase activity, zinc-dependent" BROAD []
is_obsolete: true
replaced_by: GO:0004022

[Term]
id: GO:0004025
name: obsolete alcohol dehydrogenase (NAD+) activity, iron-dependent
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [GOC:mah]
comment: This term was obsoleted because it represents the same activity as alcohol dehydrogenase (NAD+) activity ; GO:0004022.
synonym: "alcohol dehydrogenase activity, iron-dependent" BROAD []
is_obsolete: true
replaced_by: GO:0004022

[Term]
id: GO:0004026
name: alcohol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84]
synonym: "AATASE activity" RELATED [EC:2.3.1.84]
synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" RELATED [EC:2.3.1.84]
synonym: "alcohol acetyltransferase activity" RELATED [EC:2.3.1.84]
xref: EC:2.3.1.84
xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN
xref: RHEA:17229
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity

[Term]
id: GO:0004027
name: alcohol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "3-hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "3beta-hydroxy steroid sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "3beta-hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "5alpha-androstenol sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "alcohol sulphotransferase activity" EXACT []
synonym: "alcohol/hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "dehydroepiandrosterone sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" RELATED [EC:2.8.2.2]
synonym: "estrogen sulfokinase activity" RELATED [EC:2.8.2.2]
synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2]
synonym: "HST" RELATED [EC:2.8.2.2]
synonym: "hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2]
synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2]
synonym: "steroid sulfokinase activity" RELATED [EC:2.8.2.2]
synonym: "sterol sulfokinase activity" RELATED [EC:2.8.2.2]
synonym: "sterol sulfotransferase activity" RELATED [EC:2.8.2.2]
xref: EC:2.8.2.2
xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-176494 "SULTs transfer (SO4)2- group to 27HCHOL"
xref: Reactome:R-HSA-176609 "cholesterol + PAPS => cholesterol sulfate + PAP"
xref: RHEA:22552
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004028
name: 3-chloroallyl aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [GOC:curators]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004029
name: aldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH." [RHEA:16185]
synonym: "aldehyde dehydrogenase (NAD+)" RELATED [EC:1.2.1.3]
synonym: "aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.3]
synonym: "CoA-independent aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3]
synonym: "m-methylbenzaldehyde dehydrogenase activity" RELATED [EC:1.2.1.3]
synonym: "NAD-aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3]
synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" RELATED [EC:1.2.1.3]
synonym: "NAD-dependent aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3]
synonym: "NAD-linked aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3]
synonym: "propionaldehyde dehydrogenase activity" RELATED [EC:1.2.1.3]
xref: EC:1.2.1.3
xref: MetaCyc:ALDHDEHYDROG-RXN
xref: Reactome:R-HSA-380608 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid"
xref: Reactome:R-HSA-389609 "ALDH3A2-2 oxidizes pristanal to pristanate"
xref: Reactome:R-HSA-5692261 "ALDH3A2-1 oxidises HD2NAL to PALM"
xref: Reactome:R-HSA-5696091 "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH"
xref: Reactome:R-HSA-6808487 "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG"
xref: Reactome:R-HSA-6808496 "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG"
xref: Reactome:R-HSA-6813749 "ALDH1A1 oxidises GA to DGA"
xref: Reactome:R-HSA-71691 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]"
xref: Reactome:R-HSA-71723 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]"
xref: RHEA:16185
xref: UM-BBD_reactionID:r0003
xref: UM-BBD_reactionID:r0023
xref: UM-BBD_reactionID:r0605
xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+)
is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004030
name: aldehyde dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5]
synonym: "aldehyde:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.5]
synonym: "ALDH" RELATED [EC:1.2.1.5]
xref: EC:1.2.1.5
xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADORNOP+-RXN
xref: Reactome:R-HSA-5692283 "ALD3A1 oxidises 4HPCP to CXPA"
xref: Reactome:R-HSA-5696080 "ALDH3B1 oxidises HXAL to PALM"
xref: Reactome:R-HSA-6808464 "ALDH3B2 oxidises HXAL to PALM"
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004031
name: aldehyde oxidase activity
namespace: molecular_function
alt_id: GO:0050250
def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1]
synonym: "aldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.1]
synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1]
synonym: "retinal oxidase activity" NARROW []
xref: EC:1.2.3.1
xref: MetaCyc:ALDEHYDE-OXIDASE-RXN
xref: Reactome:R-HSA-3204311 "AOX1 oxidises PXL to PDXate"
xref: RHEA:16829
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0004032
name: aldose reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21]
synonym: "aldehyde reductase activity" RELATED [EC:1.1.1.21]
synonym: "alditol:NADP+ 1-oxidoreductase activity" EXACT []
synonym: "aldose reductase activity" RELATED [EC:1.1.1.21]
synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21]
xref: KEGG_REACTION:R02820
xref: Reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol"
xref: Reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"
xref: RHEA:12789
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity

[Term]
id: GO:0004033
name: aldo-keto reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai]
synonym: "alcohol dehydrogenase (NADP+) activity" NARROW []
synonym: "aldo-keto reductase (NADP) activity" EXACT []
synonym: "aldo-keto reductase (NADP+) activity" EXACT []
synonym: "aldo-keto reductase activity" EXACT []
synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw]
xref: Reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one"
xref: Reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol"
xref: Reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one"
xref: Reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol"
xref: Reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one"
xref: Reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one"
xref: Reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol"
xref: Reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol"
xref: Reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol"
xref: Reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one"
xref: Reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one"
xref: Reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol"
xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-"
xref: Reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL"
xref: Reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH"
xref: Reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione"
xref: Reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA"
xref: Reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA"
xref: Reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3"
xref: Reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"
is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004034
name: aldose 1-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3]
synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3]
synonym: "mutarotase activity" RELATED [EC:5.1.3.3]
xref: EC:5.1.3.3
xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0004035
name: alkaline phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
synonym: "alkaline phenyl phosphatase activity" RELATED [EC:3.1.3.1]
synonym: "alkaline phosphohydrolase activity" RELATED [EC:3.1.3.1]
synonym: "alkaline phosphomonoesterase activity" RELATED [EC:3.1.3.1]
synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1]
synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" RELATED [EC:3.1.3.1]
synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" RELATED [EC:3.1.3.1]
synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1]
xref: EC:3.1.3.1
xref: MetaCyc:ALKAPHOSPHA-RXN
xref: Reactome:R-HSA-8878787 "ALPI dimer hydrolyses phosphate monoesters"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004037
name: allantoicase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11016]
synonym: "allantoate amidinohydrolase activity" RELATED [EC:3.5.3.4]
synonym: "allantoine amidinohydrolase activity" EXACT []
xref: EC:3.5.3.4
xref: KEGG_REACTION:R02422
xref: MetaCyc:ALLANTOICASE-RXN
xref: RHEA:11016
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004038
name: allantoinase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5]
synonym: "(S)-allantoin amidohydrolase activity" RELATED [EC:3.5.2.5]
xref: EC:3.5.2.5
xref: MetaCyc:ALLANTOINASE-RXN
xref: RHEA:17029
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004039
name: allophanate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4." [EC:3.5.1.54, RHEA:19029]
synonym: "allophanate lyase activity" RELATED [EC:3.5.1.54]
synonym: "urea-1-carboxylate amidohydrolase activity" RELATED [EC:3.5.1.54]
xref: EC:3.5.1.54
xref: KEGG_REACTION:R00005
xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN
xref: RHEA:19029
xref: UM-BBD_reactionID:r0848
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004040
name: amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+." [RHEA:12020]
synonym: "acetamidase activity" EXACT []
synonym: "acylamidase activity" RELATED [EC:3.5.1.4]
synonym: "acylamide amidohydrolase activity" RELATED [EC:3.5.1.4]
synonym: "acylase activity" RELATED [EC:3.5.1.4]
synonym: "amidohydrolase activity" RELATED [EC:3.5.1.4]
synonym: "fatty acylamidase activity" RELATED [EC:3.5.1.4]
synonym: "N-acetylaminohydrolase activity" RELATED [EC:3.5.1.4]
xref: EC:3.5.1.4
xref: MetaCyc:AMIDASE-RXN
xref: RHEA:12020
xref: UM-BBD_reactionID:r0084
xref: UM-BBD_reactionID:r0375
xref: UM-BBD_reactionID:r1440
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004042
name: L-glutamate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+." [RHEA:24292]
synonym: "acetyl-CoA:L-glutamate N-acetyltransferase activity" EXACT []
synonym: "acetylglutamate acetylglutamate synthetase activity" RELATED [EC:2.3.1.1]
synonym: "AGAS" RELATED [EC:2.3.1.1]
synonym: "amino acid acetyltransferase activity" RELATED [EC:2.3.1.1]
synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1]
synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1]
xref: KEGG_REACTION:R00259
xref: MetaCyc:N-ACETYLTRANSFER-RXN
xref: Reactome:R-HSA-70542 "glutamate + acetyl CoA => N-acetyl glutamate + CoA"
xref: RHEA:24292
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004043
name: L-aminoadipate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
synonym: "2-aminoadipate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31]
synonym: "2-aminoadipic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31]
synonym: "AAR" RELATED [EC:1.2.1.31]
synonym: "alpha-aminoadipate reductase activity" RELATED [EC:1.2.1.31]
synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31]
synonym: "aminoadipate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31]
synonym: "aminoadipate-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31]
synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" RELATED [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" RELATED [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" RELATED [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" RELATED [EC:1.2.1.31]
xref: EC:1.2.1.31
xref: MetaCyc:1.2.1.31-RXN
xref: Reactome:R-HSA-70941 "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+"
xref: RHEA:12308
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004044
name: amidophosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O." [EC:2.4.2.14, RHEA:14905]
synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" RELATED [EC:2.4.2.14]
synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "phosphoribose pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "phosphoribosyl pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" RELATED [EC:2.4.2.14]
synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" RELATED [EC:2.4.2.14]
xref: EC:2.4.2.14
xref: KEGG_REACTION:R01072
xref: MetaCyc:PRPPAMIDOTRANS-RXN
xref: Reactome:R-HSA-73815 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate"
xref: RHEA:14905
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0004045
name: aminoacyl-tRNA hydrolase activity
namespace: molecular_function
alt_id: GO:0019850
alt_id: GO:0019851
def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]
synonym: "aminoacyl-transfer ribonucleate hydrolase activity" RELATED [EC:3.1.1.29]
synonym: "aminoacyl-tRNA aminoacylhydrolase activity" RELATED [EC:3.1.1.29]
synonym: "aminoacyl-tRNA hydrolase reaction" EXACT []
synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242]
synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" RELATED [EC:3.1.1.29]
synonym: "peptidyl-tRNA hydrolase activity" RELATED [EC:3.1.1.29]
xref: EC:3.1.1.29
xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN
xref: RHEA:54448
is_a: GO:0052689 ! carboxylic ester hydrolase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0004046
name: aminoacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]
synonym: "acylase I activity" NARROW [EC:3.5.1.14]
synonym: "alpha-N-acylaminoacid hydrolase activity" RELATED [EC:3.5.1.14]
synonym: "amido acid deacylase activity" RELATED [EC:3.5.1.14]
synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14]
synonym: "benzamidase activity" RELATED [EC:3.5.1.14]
synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14]
synonym: "hippurase activity" RELATED [EC:3.5.1.14]
synonym: "histozyme activity" RELATED [EC:3.5.1.14]
synonym: "L-amino-acid acylase activity" RELATED [EC:3.5.1.14]
synonym: "L-aminoacylase activity" RELATED [EC:3.5.1.14]
synonym: "long acyl amidoacylase activity" RELATED [EC:3.5.1.14]
synonym: "N-acyl-L-amino-acid amidohydrolase activity" RELATED [EC:3.5.1.14]
synonym: "short acyl amidoacylase activity" RELATED [EC:3.5.1.14]
xref: EC:3.5.1.14
xref: MetaCyc:AMINOACYLASE-RXN
xref: Reactome:R-HSA-5433074 "ACY1:Zn2+ dimer hydrolyses mercapturic acids"
xref: Reactome:R-HSA-5579081 "Defective ACY1 does not hydrolyse mercapturic acids"
xref: Reactome:R-HSA-9638046 "ACY3:Zn2+ dimer hydrolyses mercapturic acids"
xref: Reactome:R-HSA-9753944 "ACY1:Zn2+ dimer deacetylates NAC to L-Cys"
xref: RHEA:15565
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004047
name: aminomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
synonym: "glycine synthase activity" RELATED [EC:2.1.2.10]
synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10]
synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" RELATED [EC:2.1.2.10]
synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" RELATED [EC:2.1.2.10]
synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" RELATED [EC:2.1.2.10]
synonym: "T-protein" RELATED [EC:2.1.2.10]
synonym: "tetrahydrofolate aminomethyltransferase activity" RELATED [EC:2.1.2.10]
xref: EC:2.1.2.10
xref: MetaCyc:GCVT-RXN
xref: Reactome:R-HSA-5693977 "AMT transfers NH2CH2 from GCSH:SAMDLL to THF"
xref: RHEA:16945
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004048
name: anthranilate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11768]
synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.18]
synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.18]
synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" RELATED [EC:2.4.2.18]
synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.18]
synonym: "phosphoribosyl-anthranilate diphosphorylase activity" RELATED [EC:2.4.2.18]
synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" RELATED [EC:2.4.2.18]
synonym: "phosphoribosylanthranilate pyrophosphorylase activity" RELATED [EC:2.4.2.18]
synonym: "phosphoribosylanthranilate transferase activity" RELATED [EC:2.4.2.18]
synonym: "PRT" RELATED [EC:2.4.2.18]
xref: EC:2.4.2.18
xref: KEGG_REACTION:R01073
xref: MetaCyc:PRTRANS-RXN
xref: RHEA:11768
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0004049
name: anthranilate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27]
synonym: "anthranilate synthetase activity" RELATED [EC:4.1.3.27]
synonym: "chorismate pyruvate-lyase (amino-accepting) activity" RELATED [EC:4.1.3.27]
xref: EC:4.1.3.27
xref: MetaCyc:ANTHRANSYN-RXN
xref: RHEA:21732
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004050
name: apyrase activity
namespace: molecular_function
def: "Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs)." [EC:3.6.1.5]
xref: EC:3.6.1.5
xref: MetaCyc:RXN-14024
xref: RHEA:36795
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004051
name: arachidonate 5-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4." [RHEA:32307]
comment: Note that this is a multi-step reaction.
synonym: "5-delta-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "5-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "5Delta-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "arachidonate:oxygen 5-oxidoreductase activity" RELATED [EC:1.13.11.34]
synonym: "arachidonic 5-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "arachidonic acid 5-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "delta5-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34]
synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34]
synonym: "leukotriene-A4 synthase activity" RELATED [EC:1.13.11.34]
synonym: "LTA synthase activity" NARROW [EC:1.13.11.34]
xref: EC:1.13.11.34
xref: RHEA:32307
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004052
name: arachidonate 12(S)-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10428]
synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31]
synonym: "12Delta-lipoxygenase activity" RELATED [EC:1.13.11.31]
synonym: "12S-lipoxygenase activity" RELATED [EC:1.13.11.31]
synonym: "arachidonate:oxygen 12-oxidoreductase activity" RELATED [EC:1.13.11.31]
synonym: "C-12 lipoxygenase activity" RELATED [EC:1.13.11.31]
synonym: "delta12-lipoxygenase activity" RELATED [EC:1.13.11.31]
synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31]
synonym: "LTA4 synthase activity" RELATED [EC:1.13.11.31]
xref: EC:1.13.11.31
xref: KEGG_REACTION:R01596
xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN
xref: Reactome:R-HSA-2161948 "Arachidonate  is converted to 12-oxoETE by ALOX12"
xref: Reactome:R-HSA-2161950 "Arachidonate is oxidised to 12R-HpETE by ALOX12B"
xref: Reactome:R-HSA-2161964 "Arachidonate is oxidised to 12S-HpETE by ALOX12/15"
xref: Reactome:R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA"
xref: Reactome:R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6"
xref: Reactome:R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3"
xref: Reactome:R-HSA-9026007 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3"
xref: RHEA:10428
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004053
name: arginase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1]
synonym: "arginine amidinase activity" RELATED [EC:3.5.3.1]
synonym: "arginine transamidinase activity" RELATED [EC:3.5.3.1]
synonym: "canavanase activity" RELATED [EC:3.5.3.1]
synonym: "L-arginase activity" RELATED [EC:3.5.3.1]
synonym: "L-arginine amidinohydrolase activity" RELATED [EC:3.5.3.1]
xref: EC:3.5.3.1
xref: MetaCyc:ARGINASE-RXN
xref: Reactome:R-HSA-452036 "arginine + H2O => ornithine + urea [ARG2]"
xref: Reactome:R-HSA-70569 "arginine + H2O => ornithine + urea [ARG1]"
xref: RHEA:20569
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004054
name: arginine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+." [EC:2.7.3.3, RHEA:22940]
synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" RELATED [EC:2.7.3.3]
synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3]
synonym: "arginine phosphokinase activity" RELATED [EC:2.7.3.3]
synonym: "ATP:L-arginine N-phosphotransferase activity" RELATED [EC:2.7.3.3]
xref: EC:2.7.3.3
xref: KEGG_REACTION:R00554
xref: MetaCyc:ARGININE-KINASE-RXN
xref: RHEA:22940
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004055
name: argininosuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5]
synonym: "arginine succinate synthetase activity" RELATED [EC:6.3.4.5]
synonym: "argininosuccinate synthetase activity" RELATED [EC:6.3.4.5]
synonym: "argininosuccinic acid synthetase activity" RELATED [EC:6.3.4.5]
synonym: "arginosuccinate synthetase activity" RELATED [EC:6.3.4.5]
synonym: "citrulline--aspartate ligase activity" RELATED [EC:6.3.4.5]
synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" RELATED [EC:6.3.4.5]
xref: EC:6.3.4.5
xref: MetaCyc:ARGSUCCINSYN-RXN
xref: Reactome:R-HSA-70577 "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA"
xref: RHEA:10932
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004056
name: argininosuccinate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1]
synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" RELATED [EC:4.3.2.1]
synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" RELATED [EC:4.3.2.1]
synonym: "arginine-succinate lyase activity" RELATED [EC:4.3.2.1]
synonym: "argininosuccinic acid lyase activity" RELATED [EC:4.3.2.1]
synonym: "arginosuccinase activity" RELATED [EC:4.3.2.1]
synonym: "N-(L-argininosuccinate) arginine-lyase activity" RELATED [EC:4.3.2.1]
synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" RELATED [EC:4.3.2.1]
xref: EC:4.3.2.1
xref: MetaCyc:ARGSUCCINLYA-RXN
xref: Reactome:R-HSA-70573 "argininosuccinate <=> fumarate + arginine"
xref: RHEA:24020
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004057
name: arginyl-tRNA--protein transferase activity
namespace: molecular_function
alt_id: GO:0042172
def: "Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)." [PMID:16492767, PMID:9858543, RHEA:10208]
synonym: "arginine transferase activity" BROAD [EC:2.3.2.8]
synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyltransferase activity" BROAD []
xref: EC:2.3.2.8
xref: MetaCyc:ARGINYLTRANSFERASE-RXN
xref: RHEA:10208
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004058
name: aromatic-L-amino-acid decarboxylase activity
namespace: molecular_function
alt_id: GO:0016400
def: "Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28]
synonym: "5-hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "aromatic amino acid decarboxylase activity" RELATED [EC:4.1.1.28]
synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" NARROW [EC:4.1.1.28]
synonym: "aromatic-L-amino-acid carboxy-lyase activity" RELATED [EC:4.1.1.28]
synonym: "DOPA decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "L-DOPA decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "tryptophan decarboxylase activity" NARROW [EC:4.1.1.28]
xref: EC:4.1.1.28
xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN
xref: Reactome:R-HSA-209859 "Decarboxylation of 5-hydroxytryptophan forms serotonin"
xref: Reactome:R-HSA-209924 "Dopa is decarboxylated to dopamine"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004059
name: aralkylamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87]
synonym: "AANAT activity" RELATED [EC:2.3.1.87]
synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" RELATED [EC:2.3.1.87]
synonym: "arylalkylamine N-acetyltransferase activity" RELATED [EC:2.3.1.87]
synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87]
synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87]
synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87]
synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87]
xref: EC:2.3.1.87
xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-209792 "N-acetylation of serotonin"
xref: RHEA:20497
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004060
name: arylamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5]
synonym: "2-naphthylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5]
synonym: "4-aminobiphenyl N-acetyltransferase activity" RELATED [EC:2.3.1.5]
synonym: "acetyl CoA-arylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5]
synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5]
synonym: "arylamine acetylase activity" RELATED [EC:2.3.1.5]
synonym: "arylamine acetyltransferase activity" RELATED [EC:2.3.1.5]
synonym: "beta-naphthylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5]
synonym: "indoleamine N-acetyltransferase activity" RELATED [EC:2.3.1.5]
synonym: "p-aminosalicylate N-acetyltransferase activity" RELATED [EC:2.3.1.5]
xref: EC:2.3.1.5
xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-174963 "NAT1 acetylation"
xref: Reactome:R-HSA-174967 "NAT2 acetylation"
xref: Reactome:R-HSA-9753676 "NAT1,2 acetylate APAP-Cys to APAP-Mer"
xref: RHEA:16613
xref: UM-BBD_reactionID:r1333
xref: UM-BBD_reactionID:r1626
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004061
name: arylformamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9]
synonym: "aryl-formylamine amidohydrolase activity" RELATED [EC:3.5.1.9]
synonym: "formamidase I" RELATED [EC:3.5.1.9]
synonym: "formamidase II" RELATED [EC:3.5.1.9]
synonym: "formylase activity" RELATED [EC:3.5.1.9]
synonym: "formylkynureninase activity" RELATED [EC:3.5.1.9]
synonym: "formylkynurenine formamidase activity" RELATED [EC:3.5.1.9]
synonym: "kynurenine formamidase activity" RELATED [EC:3.5.1.9]
xref: EC:3.5.1.9
xref: MetaCyc:ARYLFORMAMIDASE-RXN
xref: Reactome:R-HSA-71189 "AFMID hydrolyses NFK to L-KYN"
xref: RHEA:13009
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004062
name: aryl sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1]
subset: goslim_chembl
synonym: "1-naphthol phenol sulfotransferase activity" RELATED [EC:2.8.2.1]
synonym: "2-naphtholsulfotransferase activity" RELATED [EC:2.8.2.1]
synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" RELATED [EC:2.8.2.1]
synonym: "4-nitrocatechol sulfokinase activity" RELATED [EC:2.8.2.1]
synonym: "aryl sulphotransferase activity" EXACT []
synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1]
synonym: "dopamine sulfotransferase activity" RELATED [EC:2.8.2.1]
synonym: "p-nitrophenol sulfotransferase activity" RELATED [EC:2.8.2.1]
synonym: "phenol sulfokinase activity" RELATED [EC:2.8.2.1]
synonym: "phenol sulfotransferase activity" RELATED [EC:2.8.2.1]
synonym: "PST" RELATED [EC:2.8.2.1]
synonym: "ritodrine sulfotransferase activity" RELATED [EC:2.8.2.1]
synonym: "sulfokinase activity" RELATED [EC:2.8.2.1]
xref: EC:2.8.2.1
xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-158468 "SULT1A1 dimer sulfonates PARA to PARA-SO4"
xref: Reactome:R-HSA-158849 "Phenol can form a sulfate conjugate"
xref: Reactome:R-HSA-158860 "SULT1A1 dimer sulfonates NHABP"
xref: Reactome:R-HSA-159358 "SULT1A3,4 dimers sulfate DA to DAOS"
xref: Reactome:R-HSA-176474 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP"
xref: Reactome:R-HSA-176585 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP"
xref: Reactome:R-HSA-176646 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP"
xref: RHEA:12164
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004063
name: aryldialkylphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1]
synonym: "A-esterase activity" BROAD [EC:3.1.8.1]
synonym: "aryltriphosphatase activity" RELATED [EC:3.1.8.1]
synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT []
synonym: "esterase B1" RELATED [EC:3.1.8.1]
synonym: "esterase E4" RELATED [EC:3.1.8.1]
synonym: "OPH" RELATED [EC:3.1.8.1]
synonym: "organophosphate esterase activity" BROAD []
synonym: "organophosphate hydrolase activity" BROAD []
synonym: "organophosphorus acid anhydrase activity" BROAD []
synonym: "organophosphorus hydrolase activity" BROAD []
synonym: "paraoxon esterase activity" NARROW []
synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1]
synonym: "paraoxonase activity" BROAD [EC:3.1.8.1]
synonym: "phosphotriesterase activity" NARROW [EC:3.1.8.1]
synonym: "pirimiphos-methyloxon esterase activity" NARROW []
xref: EC:3.1.8.1
xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN
xref: RHEA:18053
xref: UM-BBD_enzymeID:r0067
xref: UM-BBD_reactionID:r0064
is_a: GO:0016795 ! phosphoric triester hydrolase activity

[Term]
id: GO:0004064
name: arylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]
synonym: "A-esterase activity" BROAD [EC:3.1.1.2]
synonym: "aromatic esterase" NARROW [EC:3.1.1.2]
synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2]
synonym: "paraoxonase activity" BROAD [EC:3.1.1.2]
xref: EC:3.1.1.2
xref: MetaCyc:ARYLESTERASE-RXN
xref: RHEA:17309
xref: UM-BBD_reactionID:r0757
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004065
name: arylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1]
synonym: "4-methylumbelliferyl sulfatase activity" RELATED [EC:3.1.6.1]
synonym: "aryl-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.1]
synonym: "aryl-sulfate sulphohydrolase activity" RELATED [EC:3.1.6.1]
synonym: "aryl-sulphate sulphohydrolase activity" RELATED [EC:3.1.6.1]
synonym: "arylsulfohydrolase activity" RELATED [EC:3.1.6.1]
synonym: "arylsulphatase activity" EXACT []
synonym: "estrogen sulfatase activity" RELATED [EC:3.1.6.1]
synonym: "nitrocatechol sulfatase activity" RELATED [EC:3.1.6.1]
synonym: "p-nitrophenyl sulfatase activity" RELATED [EC:3.1.6.1]
synonym: "phenolsulfatase activity" RELATED [EC:3.1.6.1]
synonym: "phenylsulfatase activity" RELATED [EC:3.1.6.1]
synonym: "sulfatase activity" RELATED [EC:3.1.6.1]
xref: EC:3.1.6.1
xref: MetaCyc:ARYLSULFAT-RXN
xref: RHEA:17261
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004066
name: asparagine synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4, RHEA:12228]
synonym: "AS" RELATED [EC:6.3.5.4]
synonym: "AS-B activity" RELATED [EC:6.3.5.4]
synonym: "asparagine synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.4]
synonym: "asparagine synthetase (glutamine-hydrolysing)" RELATED [EC:6.3.5.4]
synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.4]
synonym: "asparagine synthetase B activity" RELATED [EC:6.3.5.4]
synonym: "glutamine-dependent asparagine synthetase activity" RELATED [EC:6.3.5.4]
synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" RELATED [EC:6.3.5.4]
xref: EC:6.3.5.4
xref: MetaCyc:ASNSYNB-RXN
xref: Reactome:R-HSA-70599 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]"
xref: RHEA:12228
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004067
name: asparaginase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]
synonym: "alpha-asparaginase activity" RELATED [EC:3.5.1.1]
synonym: "asparaginase II" RELATED [EC:3.5.1.1]
synonym: "colaspase activity" RELATED [EC:3.5.1.1]
synonym: "crasnitin" RELATED [EC:3.5.1.1]
synonym: "elspar" RELATED [EC:3.5.1.1]
synonym: "L-asparaginase activity" RELATED [EC:3.5.1.1]
synonym: "L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.1]
synonym: "leunase activity" RELATED [EC:3.5.1.1]
xref: EC:3.5.1.1
xref: Reactome:R-HSA-6797627 "ASPG hydrolyses L-Asn to L-Asp"
xref: RHEA:21016
is_a: GO:0004040 ! amidase activity

[Term]
id: GO:0004068
name: aspartate 1-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "aspartate alpha-decarboxylase activity" RELATED [EC:4.1.1.11]
synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11]
synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" RELATED [EC:4.1.1.11]
synonym: "L-aspartate 1-carboxy-lyase activity" RELATED [EC:4.1.1.11]
synonym: "L-aspartate alpha-decarboxylase activity" RELATED [EC:4.1.1.11]
xref: EC:4.1.1.11
xref: MetaCyc:ASPDECARBOX-RXN
xref: RHEA:19497
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004069
name: L-aspartate:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "2-oxoglutarate-glutamate aminotransferase activity" RELATED [EC:2.6.1.1]
synonym: "AAT" RELATED [EC:2.6.1.1]
synonym: "aspartate alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.1]
synonym: "aspartate aminotransferase activity" BROAD []
synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1]
synonym: "aspartate-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.1]
synonym: "aspartate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.1]
synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "AspT" RELATED [EC:2.6.1.1]
synonym: "glutamate oxaloacetate transaminase activity" RELATED [EC:2.6.1.1]
synonym: "glutamate-oxalacetate aminotransferase activity" RELATED [EC:2.6.1.1]
synonym: "glutamate-oxalate transaminase activity" RELATED [EC:2.6.1.1]
synonym: "glutamic oxalic transaminase activity" RELATED [EC:2.6.1.1]
synonym: "glutamic--aspartic transaminase activity" RELATED [EC:2.6.1.1]
synonym: "glutamic--oxaloacetic transaminase activity" RELATED [EC:2.6.1.1]
synonym: "glutamic-aspartic aminotransferase activity" RELATED [EC:2.6.1.1]
synonym: "glutamic-oxalacetic transaminase activity" RELATED [EC:2.6.1.1]
synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1]
synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1]
synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.1]
synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.1]
synonym: "L-aspartate-2-oxoglutarate-transaminase activity" RELATED [EC:2.6.1.1]
synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.1]
synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "oxaloacetate transferase activity" RELATED [EC:2.6.1.1]
synonym: "oxaloacetate-aspartate aminotransferase activity" RELATED [EC:2.6.1.1]
synonym: "transaminase A activity" RELATED [EC:2.6.1.1]
xref: EC:2.6.1.1
xref: KEGG_REACTION:R00355
xref: MetaCyc:ASPAMINOTRANS-RXN
xref: Reactome:R-HSA-70581 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]"
xref: Reactome:R-HSA-70592 "PXLP-K259-GOT1 transaminates 2-OG and L-Asp"
xref: Reactome:R-HSA-70596 "GOT2 dimer deaminates L-Asp"
xref: Reactome:R-HSA-70613 "GOT2 transaminates OA and L-Glu"
xref: RHEA:21824
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004070
name: aspartate carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate." [EC:2.1.3.2, RHEA:20013]
synonym: "aspartate carbamyltransferase activity" RELATED [EC:2.1.3.2]
synonym: "aspartate transcarbamoylase activity" RELATED [EC:2.1.3.2]
synonym: "aspartate transcarbamylase activity" RELATED [EC:2.1.3.2]
synonym: "aspartic acid transcarbamoylase activity" RELATED [EC:2.1.3.2]
synonym: "aspartic carbamyltransferase activity" RELATED [EC:2.1.3.2]
synonym: "aspartic transcarbamylase activity" RELATED [EC:2.1.3.2]
synonym: "ATCase activity" RELATED [EC:2.1.3.2]
synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" RELATED [EC:2.1.3.2]
synonym: "carbamoylaspartotranskinase activity" RELATED [EC:2.1.3.2]
synonym: "carbamylaspartotranskinase activity" RELATED [EC:2.1.3.2]
synonym: "L-aspartate transcarbamoylase activity" RELATED [EC:2.1.3.2]
synonym: "L-aspartate transcarbamylase activity" RELATED [EC:2.1.3.2]
xref: EC:2.1.3.2
xref: KEGG_REACTION:R01397
xref: MetaCyc:ASPCARBTRANS-RXN
xref: Reactome:R-HSA-73573 "CAD hexamer transforms CAP to N-carb-L-Asp"
xref: RHEA:20013
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0004071
name: aspartate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1]
synonym: "asparagine synthetase activity" RELATED [EC:6.3.1.1]
synonym: "L-asparagine synthetase activity" RELATED [EC:6.3.1.1]
synonym: "L-aspartate:ammonia ligase (AMP-forming)" RELATED [EC:6.3.1.1]
xref: EC:6.3.1.1
xref: MetaCyc:ASNSYNA-RXN
xref: RHEA:11372
is_a: GO:0016211 ! ammonia ligase activity

[Term]
id: GO:0004072
name: aspartate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+." [EC:2.7.2.4, RHEA:23776]
synonym: "aspartic kinase activity" RELATED [EC:2.7.2.4]
synonym: "aspartokinase activity" RELATED [EC:2.7.2.4]
synonym: "ATP:L-aspartate 4-phosphotransferase activity" RELATED [EC:2.7.2.4]
synonym: "beta-aspartokinase activity" RELATED [EC:2.7.2.4]
xref: EC:2.7.2.4
xref: KEGG_REACTION:R00480
xref: MetaCyc:ASPARTATEKIN-RXN
xref: RHEA:23776
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004073
name: aspartate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH." [EC:1.2.1.11, RHEA:24284]
synonym: "ASA dehydrogenase activity" RELATED [EC:1.2.1.11]
synonym: "aspartate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11]
synonym: "aspartic beta-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11]
synonym: "aspartic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11]
synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.11]
synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11]
synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" RELATED [EC:1.2.1.11]
xref: EC:1.2.1.11
xref: KEGG_REACTION:R02291
xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:24284
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004074
name: biliverdin reductase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: bilirubin IXalpha + NAD(P)+ = biliverdin IXalpha + NAD(P)H + H+." [EC:1.3.1.24]
synonym: "bilirubin:NAD(P)+ oxidoreductase activity" RELATED [EC:1.3.1.24]
xref: EC:1.3.1.24
xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN
xref: Reactome:R-HSA-189384 "BLVRA:Zn2+, BLVRB reduce BV to BIL"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004075
name: biotin carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" RELATED [EC:6.3.4.14]
synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" RELATED [EC:6.3.4.14]
xref: EC:6.3.4.14
xref: MetaCyc:BIOTIN-CARBOXYL-RXN
xref: RHEA:13501
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004076
name: biotin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+." [EC:2.8.1.6, RHEA:22060]
synonym: "biotin synthetase activity" RELATED [EC:2.8.1.6]
synonym: "dethiobiotin:sulfur sulfurtransferase activity" RELATED [EC:2.8.1.6]
xref: EC:2.8.1.6
xref: KEGG_REACTION:R01078
xref: MetaCyc:2.8.1.6-RXN
xref: RHEA:22060
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0004077
name: biotin--[biotin carboxyl-carrier protein] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H+ + N(6)-biotinyl-L-lysyl-[protein]." [RHEA:11756]
synonym: "acetyl CoA holocarboxylase synthetase activity" RELATED [EC:6.3.4.15]
synonym: "acetyl coenzyme A holocarboxylase synthetase activity" RELATED [EC:6.3.4.15]
synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" RELATED [EC:6.3.4.15]
synonym: "biotin holoenzyme synthetase activity" RELATED [EC:6.3.4.15]
synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" RELATED [EC:6.3.4.15]
synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15]
synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" RELATED [EC:6.3.4.15]
synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15]
synonym: "biotin-acetyl-CoA-carboxylase ligase activity" RELATED [EC:6.3.4.15]
synonym: "biotin-protein ligase activity" EXACT []
synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" RELATED [EC:6.3.4.15]
synonym: "biotin:apocarboxylase ligase activity" RELATED [EC:6.3.4.15]
synonym: "HCS" RELATED [EC:6.3.4.15]
xref: EC:6.3.4.15
xref: MetaCyc:BIOTINLIG-RXN
xref: RHEA:11756
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004078
name: obsolete biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [GOC:rynl]
comment: The reason for obsoletion is this term is more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0004077

[Term]
id: GO:0004079
name: obsolete biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [GOC:rynl]
comment: The reason for obsoletion is this term is more specific than the specificity of any known gene product.
synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004077

[Term]
id: GO:0004080
name: obsolete biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [GOC:rynl]
comment: The reason for obsoletion is this term is more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0004077

[Term]
id: GO:0004081
name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726]
synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.17]
synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17]
synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17]
synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17]
synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17]
synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17]
synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" RELATED [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" RELATED [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW []
synonym: "diadenosine P1,P4-tetraphosphatase activity" RELATED [EC:3.6.1.17]
synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17]
synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17]
synonym: "dinucleoside tetraphosphatase activity" RELATED [EC:3.6.1.17]
synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" RELATED [EC:3.6.1.17]
synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.17]
xref: EC:3.6.1.17
xref: MetaCyc:3.6.1.17-RXN
xref: Reactome:R-HSA-5696197 "NUDT2 hydrolyses GP4G to GTP, GMP"
xref: RHEA:22484
is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity

[Term]
id: GO:0004082
name: bisphosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4]
synonym: "2,3-bisphosphoglycerate mutase activity" RELATED [EC:5.4.2.4]
synonym: "2,3-bisphosphoglycerate synthase activity" RELATED [EC:5.4.2.4]
synonym: "2,3-diphosphoglycerate mutase activity" RELATED [EC:5.4.2.4]
synonym: "2,3-diphosphoglycerate synthase activity" RELATED [EC:5.4.2.4]
synonym: "2,3-diphosphoglyceromutase activity" RELATED [EC:5.4.2.4]
synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" RELATED [EC:5.4.2.4]
synonym: "biphosphoglycerate synthase activity" RELATED [EC:5.4.2.4]
synonym: "bisphosphoglycerate synthase activity" RELATED [EC:5.4.2.4]
synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4]
synonym: "BPGM activity" RELATED [EC:5.4.2.4]
synonym: "diphosphoglycerate mutase activity" RELATED [EC:5.4.2.4]
synonym: "diphosphoglyceric mutase activity" RELATED [EC:5.4.2.4]
synonym: "diphosphoglyceromutase activity" RELATED [EC:5.4.2.4]
synonym: "DPGM" RELATED [EC:5.4.2.4]
synonym: "glycerate phosphomutase activity" RELATED [EC:5.4.2.4]
xref: EC:5.4.2.4
xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN
xref: Reactome:R-HSA-6798335 "BPGM dimer isomerises 1,3BPG to 2,3BPG"
xref: RHEA:17765
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0004083
name: obsolete bisphosphoglycerate 2-phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate." [PMID:8567632, PMID:9452443]
comment: This term was deprecated because there is no evidence that this reaction exists.
is_obsolete: true

[Term]
id: GO:0004084
name: branched-chain-amino-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: a branched-chain amino acid (L-leucine, L-isoleucine and L-valine) + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42]
synonym: "branched-chain amino acid aminotransferase activity" EXACT []
synonym: "branched-chain amino acid-glutamate transaminase activity" RELATED [EC:2.6.1.42]
synonym: "branched-chain aminotransferase activity" RELATED [EC:2.6.1.42]
synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.42]
synonym: "glutamate-branched-chain amino acid transaminase activity" RELATED [EC:2.6.1.42]
synonym: "L-branched chain amino acid aminotransferase activity" RELATED [EC:2.6.1.42]
synonym: "transaminase B activity" RELATED [EC:2.6.1.42]
xref: EC:2.6.1.42
xref: Reactome:R-HSA-508179 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]"
xref: Reactome:R-HSA-508189 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]"
xref: Reactome:R-HSA-70723 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]"
xref: Reactome:R-HSA-70724 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004085
name: obsolete butyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of short-chain fatty acyl-CoA dehydrogenase activity; GO:0016937.
is_obsolete: true
replaced_by: GO:0016937

[Term]
id: GO:0004086
name: obsolete carbamoyl-phosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate." [GOC:mah]
comment: This term was made obsolete because it is a grouping term based on name, rather than on function.
synonym: "carbamoyl phosphate synthase activity" EXACT []
synonym: "carbamoyl-phosphate synthase activity" EXACT []
is_obsolete: true
consider: GO:0004087
consider: GO:0004088

[Term]
id: GO:0004087
name: carbamoyl-phosphate synthase (ammonia) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate." [EC:6.3.4.16, RHEA:18029]
synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT []
synonym: "carbamoyl-phosphate synthetase (ammonia) activity" RELATED [EC:6.3.4.16]
synonym: "carbamoyl-phosphate synthetase I activity" RELATED [EC:6.3.4.16]
synonym: "carbamoylphosphate synthase (ammonia)" RELATED [EC:6.3.4.16]
synonym: "carbamoylphosphate synthase activity" RELATED [EC:6.3.4.16]
synonym: "carbamoylphosphate synthetase (ammonia) activity" RELATED [EC:6.3.4.16]
synonym: "carbamylphosphate synthetase activity" RELATED [EC:6.3.4.16]
synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16]
synonym: "carbmoylphosphate synthetase activity" RELATED [EC:6.3.4.16]
synonym: "carbon-dioxide--ammonia ligase activity" RELATED [EC:6.3.4.16]
synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" RELATED [EC:6.3.4.16]
synonym: "CPS I activity" NARROW [EC:6.3.4.16]
xref: EC:6.3.4.16
xref: KEGG_REACTION:R00149
xref: MetaCyc:RXN-13202
xref: Reactome:R-HSA-70555 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]"
xref: RHEA:18029
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004088
name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5, RHEA:18633]
synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT []
synonym: "carbamoyl phosphate synthetase activity" RELATED [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" RELATED [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" RELATED [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.5]
synonym: "carbamoylphosphate synthetase II activity" RELATED [EC:6.3.5.5]
synonym: "carbamyl phosphate synthetase (glutamine) activity" RELATED [EC:6.3.5.5]
synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" RELATED [EC:6.3.5.5]
synonym: "CPS activity" RELATED [EC:6.3.5.5]
synonym: "GD-CPSase activity" RELATED [EC:6.3.5.5]
synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" RELATED [EC:6.3.5.5]
synonym: "glutamine-dependent carbamyl phosphate synthetase activity" RELATED [EC:6.3.5.5]
synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" RELATED [EC:6.3.5.5]
xref: EC:6.3.5.5
xref: MetaCyc:CARBPSYN-RXN
xref: Reactome:R-HSA-73577 "CAD hexamer transforms L-Gln to CAP"
xref: RHEA:18633
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004089
name: carbonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O." [EC:4.2.1.1]
synonym: "anhydrase activity" RELATED [EC:4.2.1.1]
synonym: "carbonate anhydrase activity" RELATED [EC:4.2.1.1]
synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" RELATED [EC:4.2.1.1]
synonym: "carbonate hydro-lyase activity" RELATED [EC:4.2.1.1]
synonym: "carbonic acid anhydrase activity" RELATED [EC:4.2.1.1]
synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1]
synonym: "carbonic anhydrase activity" EXACT []
synonym: "carbonic dehydratase activity" RELATED [EC:4.2.1.1]
synonym: "carboxyanhydrase activity" RELATED [EC:4.2.1.1]
xref: EC:4.2.1.1
xref: MetaCyc:RXN0-5224
xref: Reactome:R-HSA-1237045 "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton"
xref: Reactome:R-HSA-1237047 "CA4:Zn2+ hydrates CO2 to HCO3-"
xref: Reactome:R-HSA-1237059 "CA4:Zn2+ dehydrates HCO3- to CO2"
xref: Reactome:R-HSA-1237081 "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide"
xref: Reactome:R-HSA-1475017 "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)"
xref: Reactome:R-HSA-1475022 "Carbonic anhydrase dehydrates bicarbonate (cytosol)"
xref: Reactome:R-HSA-1475025 "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)"
xref: Reactome:R-HSA-1475026 "Carbonic anhydrase hydrates carbon dioxide (cytosol)"
xref: Reactome:R-HSA-1475028 "Carbonic anhydrase dehydrates bicarbonate (mitochondria)"
xref: Reactome:R-HSA-1475032 "Carbonic anhydrase hydrates carbon dioxide (mitochondria)"
xref: Reactome:R-HSA-1475435 "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-"
xref: Reactome:R-HSA-1475436 "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2"
xref: RHEA:10748
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004090
name: carbonyl reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: a secondary alcohol + NADP+ = a ketone + H+ + NADPH." [RHEA:19257]
synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184]
synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184]
synonym: "ALR3" RELATED [EC:1.1.1.184]
synonym: "carbonyl reductase activity" RELATED [EC:1.1.1.184]
synonym: "NADPH-dependent carbonyl reductase activity" RELATED [EC:1.1.1.184]
synonym: "NADPH2-dependent carbonyl reductase activity" RELATED [EC:1.1.1.184]
synonym: "nonspecific NADPH-dependent carbonyl reductase activity" RELATED [EC:1.1.1.184]
synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184]
synonym: "secondary-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.184]
synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184]
xref: EC:1.1.1.184
xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN
xref: Reactome:R-HSA-8937419 "CBR3 reduces DOX to DOXOL"
xref: RHEA:19257
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity

[Term]
id: GO:0004092
name: carnitine O-acetyltransferase activity
namespace: molecular_function
alt_id: GO:0004093
alt_id: GO:0004094
def: "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21136]
synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" RELATED [EC:2.3.1.7]
synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" RELATED [EC:2.3.1.7]
synonym: "acetylcarnitine transferase activity" RELATED [EC:2.3.1.7]
synonym: "carnitine acetyl coenzyme A transferase activity" RELATED [EC:2.3.1.7]
synonym: "carnitine acetylase activity" RELATED [EC:2.3.1.7]
synonym: "carnitine acetyltransferase activity" RELATED [EC:2.3.1.7]
synonym: "carnitine O-acetyltransferase I activity" NARROW []
synonym: "carnitine O-acetyltransferase II activity" NARROW []
synonym: "carnitine-acetyl-CoA transferase activity" RELATED [EC:2.3.1.7]
synonym: "CATC" RELATED [EC:2.3.1.7]
xref: EC:2.3.1.7
xref: KEGG_REACTION:R02396
xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-390284 "propionyl-CoA + carnitine => propionylcarnitine + CoASH"
xref: Reactome:R-HSA-390291 "acetyl-CoA + carnitine => acetylcarnitine + CoASH"
xref: RHEA:21136
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004095
name: carnitine O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21]
synonym: "acylcarnitine transferase activity" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase activity" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21]
synonym: "CPT" RELATED [EC:2.3.1.21]
synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21]
synonym: "CPT-A" RELATED [EC:2.3.1.21]
synonym: "CPT-B" RELATED [EC:2.3.1.21]
synonym: "CPTi" RELATED [EC:2.3.1.21]
synonym: "CPTo" RELATED [EC:2.3.1.21]
synonym: "L-carnitine palmitoyltransferase activity" RELATED [EC:2.3.1.21]
synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" RELATED [EC:2.3.1.21]
synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" RELATED [EC:2.3.1.21]
synonym: "palmitoylcarnitine transferase activity" RELATED [EC:2.3.1.21]
xref: EC:2.3.1.21
xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN
xref: Reactome:R-HSA-200406 "CPT1A transfers PALM to CAR"
xref: Reactome:R-HSA-200410 "CPT2 converts palmitoyl carnitine to palmitoyl-CoA"
xref: Reactome:R-HSA-9911362 "CPT1B transfers PALM to CAR"
xref: RHEA:12661
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0004096
name: catalase activity
namespace: molecular_function
alt_id: GO:0016952
alt_id: GO:0016953
def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]
synonym: "bacterial catalase-peroxidase activity" NARROW []
synonym: "caperase activity" RELATED [EC:1.11.1.6]
synonym: "CAT" RELATED [EC:1.11.1.6]
synonym: "catalase reaction" EXACT []
synonym: "catalase-peroxidase activity" RELATED [EC:1.11.1.6]
synonym: "equilase activity" RELATED [EC:1.11.1.6]
synonym: "haem catalase activity" NARROW []
synonym: "heme catalase activity" NARROW []
synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.6]
synonym: "manganese catalase activity" NARROW []
synonym: "optidase activity" RELATED [EC:1.11.1.6]
xref: EC:1.11.1.6
xref: MetaCyc:CATAL-RXN
xref: Reactome:R-HSA-1222704 "KatG reduces H2O2"
xref: Reactome:R-HSA-76031 "2 H2O2 => O2 + 2 H2O"
xref: RHEA:20309
xref: UM-BBD_enzymeID:r1335
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004097
name: catechol oxidase activity
namespace: molecular_function
alt_id: GO:0036263
alt_id: GO:0036264
alt_id: GO:0102316
def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones." [EC:1.10.3.1, PMID:22120533]
comment: GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'.
synonym: "catecholase" EXACT [EC:1.10.3.1]
synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1]
synonym: "dopamine monooxygenase activity" NARROW []
synonym: "L-DOPA monooxygenase activity" NARROW []
synonym: "L-dopa oxidase activity" NARROW []
synonym: "o-diphenol oxidoreductase" EXACT []
synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1]
synonym: "phenolase activity" BROAD [EC:1.10.3.1]
synonym: "polyphenol oxidase activity" RELATED [EC:1.10.3.1]
synonym: "pyrocatechol oxidase" BROAD []
synonym: "tyrosinase activity" BROAD [EC:1.10.3.1]
xref: EC:1.10.3.1
xref: MetaCyc:CATECHOL-OXIDASE-RXN
xref: RHEA:21632
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0004098
name: cerebroside-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate." [EC:3.1.6.8]
synonym: "arylsulfatase A activity" RELATED [EC:3.1.6.8]
synonym: "cerebroside sulfate sulfatase activity" RELATED [EC:3.1.6.8]
synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" RELATED [EC:3.1.6.8]
synonym: "cerebroside-sulphatase activity" EXACT []
xref: EC:3.1.6.8
xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN
xref: Reactome:R-HSA-1606807 "ARSA removes sulfate from PSAP(195-273):Sulfatide"
xref: Reactome:R-HSA-9840949 "ARSA removes sulfate from SM3"
xref: RHEA:21300
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004099
name: chitin deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41]
synonym: "chitin amidohydrolase activity" RELATED [EC:3.5.1.41]
xref: EC:3.5.1.41
xref: MetaCyc:CHITIN-DEACETYLASE-RXN
xref: RHEA:10464
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0004100
name: chitin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16]
synonym: "chitin synthetase activity" RELATED [EC:2.4.1.16]
synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" RELATED [EC:2.4.1.16]
synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.16]
synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.16]
synonym: "trans-N-acetylglucosaminosylase activity" RELATED [EC:2.4.1.16]
synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" RELATED [EC:2.4.1.16]
xref: EC:2.4.1.16
xref: MetaCyc:CHITIN-SYNTHASE-RXN
xref: RHEA:16637
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004102
name: choline O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18821]
synonym: "acetyl-CoA:choline O-acetyltransferase activity" RELATED [EC:2.3.1.6]
synonym: "CHOACTase activity" RELATED [EC:2.3.1.6]
synonym: "choline acetylase activity" RELATED [EC:2.3.1.6]
synonym: "choline acetyltransferase activity" RELATED [EC:2.3.1.6]
xref: EC:2.3.1.6
xref: KEGG_REACTION:R01023
xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-264622 "Cho is acetylated to AcCho by CHAT"
xref: RHEA:18821
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004103
name: choline kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+." [EC:2.7.1.32, RHEA:12837]
synonym: "ATP:choline phosphotransferase activity" RELATED []
synonym: "choline kinase (phosphorylating)" RELATED []
synonym: "choline phosphokinase activity" RELATED []
synonym: "choline-ethanolamine kinase activity" RELATED []
xref: EC:2.7.1.32
xref: KEGG_REACTION:R01021
xref: MetaCyc:CHOLINE-KINASE-RXN
xref: Reactome:R-HSA-1483004 "Cho is phosphorylated to PCho by CHK dimer"
xref: RHEA:12837
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004104
name: cholinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
subset: goslim_chembl
synonym: "acylcholine acylhydrolase activity" RELATED [EC:3.1.1.8]
synonym: "anticholineesterase activity" RELATED [EC:3.1.1.8]
synonym: "benzoylcholinesterase activity" RELATED [EC:3.1.1.8]
synonym: "BtChoEase activity" RELATED [EC:3.1.1.8]
synonym: "butyrylcholine esterase activity" RELATED [EC:3.1.1.8]
synonym: "butyrylcholinesterase activity" RELATED [EC:3.1.1.8]
synonym: "choline esterase activity" RELATED [EC:3.1.1.8]
synonym: "choline esterase II (unspecific) activity" RELATED [EC:3.1.1.8]
synonym: "non-specific cholinesterase activity" RELATED [EC:3.1.1.8]
synonym: "propionylcholinesterase activity" RELATED [EC:3.1.1.8]
synonym: "pseudocholinesterase activity" RELATED [EC:3.1.1.8]
xref: EC:3.1.1.8
xref: MetaCyc:CHOLINESTERASE-RXN
xref: RHEA:21964
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004105
name: choline-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15]
synonym: "CDP-choline pyrophosphorylase activity" RELATED [EC:2.7.7.15]
synonym: "CDP-choline synthetase activity" RELATED [EC:2.7.7.15]
synonym: "choline phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.15]
synonym: "CTP-phosphocholine cytidylyltransferase activity" RELATED [EC:2.7.7.15]
synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:phosphocholine cytidylyltransferase activity" RELATED [EC:2.7.7.15]
synonym: "CTP:phosphorylcholine cytidylyltransferase activity" RELATED [EC:2.7.7.15]
synonym: "cytidine diphosphocholine pyrophosphorylase activity" RELATED [EC:2.7.7.15]
synonym: "phosphocholine cytidylyltransferase activity" RELATED [EC:2.7.7.15]
synonym: "phosphorylcholine cytidylyltransferase activity" RELATED [EC:2.7.7.15]
synonym: "phosphorylcholine transferase activity" RELATED [EC:2.7.7.15]
synonym: "phosphorylcholine:CTP cytidylyltransferase activity" RELATED [EC:2.7.7.15]
xref: EC:2.7.7.15
xref: MetaCyc:2.7.7.15-RXN
xref: Reactome:R-HSA-1483081 "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer"
xref: RHEA:18997
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004106
name: chorismate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5, RHEA:13897]
synonym: "chorismate pyruvatemutase activity" RELATED [EC:5.4.99.5]
synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5]
xref: EC:5.4.99.5
xref: KEGG_REACTION:R01715
xref: MetaCyc:CHORISMATEMUT-RXN
xref: RHEA:13897
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0004107
name: chorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21020]
synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" RELATED [EC:4.2.3.5]
synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" RELATED [EC:4.2.3.5]
synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" RELATED [EC:4.2.3.5]
xref: EC:4.2.3.5
xref: KEGG_REACTION:R01714
xref: MetaCyc:CHORISMATE-SYNTHASE-RXN
xref: RHEA:21020
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0004108
name: citrate (Si)-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1]
synonym: "(R)-citric synthase activity" RELATED [EC:2.3.3.1]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1]
synonym: "citrate condensing enzyme activity" RELATED [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" RELATED [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" RELATED [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" RELATED [EC:2.3.3.1]
synonym: "citrate synthase activity" BROAD [EC:2.3.3.1]
synonym: "citrate synthetase activity" RELATED [EC:2.3.3.1]
synonym: "citric synthase activity" RELATED [EC:2.3.3.1]
synonym: "citric-condensing enzyme activity" RELATED [EC:2.3.3.1]
synonym: "citrogenase activity" RELATED [EC:2.3.3.1]
synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1]
synonym: "oxalacetic transacetase activity" RELATED [EC:2.3.3.1]
synonym: "oxaloacetate transacetase activity" RELATED [EC:2.3.3.1]
xref: EC:2.3.3.1
xref: Reactome:R-HSA-70975 "CS acetylates OA to citrate"
is_a: GO:0036440 ! citrate synthase activity

[Term]
id: GO:0004109
name: coproporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18257]
synonym: "coprogen oxidase activity" EXACT []
synonym: "coproporphyrinogen-III oxidase activity" EXACT []
synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" RELATED [EC:1.3.3.3]
synonym: "coproporphyrinogenase activity" EXACT []
xref: EC:1.3.3.3
xref: KEGG_REACTION:R03220
xref: MetaCyc:RXN0-1461
xref: Reactome:R-HSA-189421 "CPO transforms COPRO3 to PPGEN9"
xref: RHEA:18257
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0004110
name: corticosteroid side-chain-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17861]
synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" RELATED [EC:5.3.1.21]
synonym: "11-deoxycorticosterone ketol-isomerase activity" RELATED [EC:5.3.1.21]
xref: EC:5.3.1.21
xref: KEGG_REACTION:R04165
xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN
xref: RHEA:17861
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004111
name: creatine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+." [EC:2.7.3.2, RHEA:17157]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "adenosine triphosphate-creatine transphosphorylase activity" RELATED [EC:2.7.3.2]
synonym: "ATP:creatine N-phosphotransferase activity" RELATED [EC:2.7.3.2]
synonym: "ATP:creatine phosphotransferase activity" RELATED [EC:2.7.3.2]
synonym: "BB-CK" RELATED [EC:2.7.3.2]
synonym: "CK" RELATED [EC:2.7.3.2]
synonym: "CK-BB" RELATED [EC:2.7.3.2]
synonym: "CK-MB" RELATED [EC:2.7.3.2]
synonym: "CK-MM" RELATED [EC:2.7.3.2]
synonym: "CKMiMi" RELATED [EC:2.7.3.2]
synonym: "creatine phosphokinase activity" RELATED [EC:2.7.3.2]
synonym: "creatine phosphotransferase activity" RELATED [EC:2.7.3.2]
synonym: "MB-CK" RELATED [EC:2.7.3.2]
synonym: "Mi-CK" RELATED [EC:2.7.3.2]
synonym: "MiMi-CK" RELATED [EC:2.7.3.2]
synonym: "MM-CK" RELATED [EC:2.7.3.2]
synonym: "phosphocreatine kinase activity" RELATED [EC:2.7.3.2]
xref: EC:2.7.3.2
xref: KEGG_REACTION:R01881
xref: MetaCyc:CREATINE-KINASE-RXN
xref: Reactome:R-HSA-200318 "creatine + ATP => phosphocreatine + ADP [CKB,CKM]"
xref: Reactome:R-HSA-200326 "creatine + ATP => phosphocreatine + ADP [CK octamer]"
xref: RHEA:17157
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0004112
name: cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah]
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004113
name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37]
synonym: "2',3'-cyclic AMP phosphodiesterase activity" RELATED [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT []
synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" RELATED [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37]
synonym: "2':3'-CNMP-3'-ase activity" RELATED [EC:3.1.4.37]
synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" RELATED [EC:3.1.4.37]
synonym: "CNPase activity" RELATED [EC:3.1.4.37]
synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" RELATED [EC:3.1.4.37]
synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37]
synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37]
synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" RELATED [EC:3.1.4.37]
xref: EC:3.1.4.37
xref: MetaCyc:3.1.4.37-RXN
xref: RHEA:14489
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004114
name: 3',5'-cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate." [PMID:35216259, RHEA:14653]
synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.17]
synonym: "3',5'-cyclonucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "3',5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" RELATED [EC:3.1.4.17]
synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.17]
synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "cyclic 3',5'-phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17]
synonym: "cyclic nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" RELATED [EC:3.1.4.17]
synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" RELATED [EC:3.1.4.17]
synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.17]
synonym: "PDE" RELATED [EC:3.1.4.17]
xref: EC:3.1.4.17
xref: MetaCyc:3.1.4.17-RXN
xref: Reactome:R-HSA-162425 "p-S295-PDE3B hydrolyses cAMP to AMP"
xref: RHEA:14653
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004115
name: 3',5'-cyclic-AMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+." [GOC:ai, RHEA:25277]
synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT []
synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT []
synonym: "cAMP-specific phosphodiesterase activity" EXACT []
synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT []
xref: EC:3.1.4.53
xref: MetaCyc:RXN0-5038
xref: Reactome:R-HSA-111962 "PDE4A,C,D hydrolyse cAMP"
xref: Reactome:R-HSA-418553 "cAMP degradation by Phosphodiesterases"
xref: Reactome:R-HSA-9629675 "PDE3A hydrolyses cAMP to AMP"
xref: Reactome:R-HSA-9644869 "p-S54-PDE4B hydrolyses cAMP"
xref: Reactome:R-HSA-9705507 "PDE3B hydrolyses cAMP to AMP"
xref: Reactome:R-HSA-9708261 "PDE4A hydrolyses cAMP to AMP"
xref: Reactome:R-HSA-9865748 "PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP"
xref: RHEA:25277
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004117
name: calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin." [PMID:8557689, PMID:9419816]
synonym: "calmodulin-activated cyclic-nucleotide dual specificity phosphodiesterase activity" RELATED []
synonym: "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity" BROAD []
xref: Reactome:R-HSA-111955 "cAMP hydrolysis by Cam-PDE 1"
is_a: GO:0004115 ! 3',5'-cyclic-AMP phosphodiesterase activity
is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity

[Term]
id: GO:0004118
name: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah, PMID:15210692, PMID:35216259]
comment: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004119
name: 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah, PMID:35216259]
comment: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004120
name: obsolete photoreceptor cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [GOC:curators]
comment: The reason for obsoletion is that this term represents a gene product.
is_obsolete: true

[Term]
id: GO:0004121
name: obsolete cystathionine beta-lyase activity
namespace: molecular_function
alt_id: GO:0008799
def: "OBSOLETE. Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [GOC:curators]
comment: The reason for obsoletion is that this term is equivalent to GO:0047804 cysteine-S-conjugate beta-lyase activity.
is_obsolete: true
replaced_by: GO:0047804

[Term]
id: GO:0004122
name: cystathionine beta-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22]
synonym: "beta-thionase activity" RELATED [EC:4.2.1.22]
synonym: "L-serine hydro-lyase (adding homocysteine)" RELATED [EC:4.2.1.22]
synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" RELATED [EC:4.2.1.22]
synonym: "methylcysteine synthase activity" RELATED [EC:4.2.1.22]
synonym: "serine sulfhydrase activity" RELATED [EC:4.2.1.22]
synonym: "serine sulfhydrylase activity" RELATED [EC:4.2.1.22]
xref: EC:4.2.1.22
xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN
xref: Reactome:R-HSA-1614524 "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine"
xref: RHEA:10112
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004123
name: cystathionine gamma-lyase activity
namespace: molecular_function
alt_id: GO:0016225
def: "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:14005]
synonym: "gamma-cystathionase activity" BROAD [EC:4.4.1.1]
synonym: "homoserine deaminase activity" RELATED [EC:4.4.1.1]
synonym: "homoserine deaminase-cystathionase activity" RELATED [EC:4.4.1.1]
synonym: "homoserine dehydratase activity" RELATED [EC:4.4.1.1]
synonym: "L-cystathionine cysteine-lyase (deaminating)" BROAD [EC:4.4.1.1]
synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" RELATED [EC:4.4.1.1]
xref: KEGG_REACTION:R01001
xref: MetaCyc:RXN-15130
xref: Reactome:R-HSA-1614583 "PXLP-K212-CTH cleaves L-Cystathionine"
xref: RHEA:14005
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004124
name: cysteine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:2.5.1.47]
synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.47]
synonym: "acetylserine sulfhydrylase activity" RELATED [EC:2.5.1.47]
synonym: "cysteine synthase activity, acting on O-acetyl-L-serine" EXACT []
synonym: "cysteine synthetase activity" RELATED [EC:2.5.1.47]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" RELATED [EC:2.5.1.47]
synonym: "O-acetyl-L-serine sulfhydrylase activity" RELATED [EC:2.5.1.47]
synonym: "O-acetyl-L-serine sulfohydrolase activity" RELATED [EC:2.5.1.47]
synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47]
synonym: "O-acetylserine (thiol)-lyase activity" RELATED [EC:2.5.1.47]
synonym: "O-acetylserine sulfhydrylase activity" RELATED [EC:2.5.1.47]
synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" RELATED [EC:2.5.1.47]
synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.47]
synonym: "OAS sulfhydrylase activity" RELATED [EC:2.5.1.47]
xref: EC:2.5.1.47
xref: MetaCyc:ACSERLY-RXN
xref: RHEA:14829
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004125
name: L-seryl-tRNA(Sec) selenium transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [RHEA:22728]
synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" RELATED [EC:2.9.1.1]
synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" RELATED [EC:2.9.1.1]
synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT []
synonym: "cysteinyl-tRNASec-selenium transferase activity" RELATED [EC:2.9.1.1]
synonym: "cysteinyl-tRNASel-selenium transferase activity" RELATED [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" RELATED [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" RELATED [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNASec synthase activity" RELATED [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNASel synthase activity" RELATED [EC:2.9.1.1]
synonym: "L-seryl-tRNASec selenium transferase activity" EXACT []
synonym: "selenocysteine synthase activity" EXACT []
synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT []
synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" RELATED [EC:2.9.1.1]
xref: EC:2.9.1.1
xref: MetaCyc:2.9.1.1-RXN
xref: RHEA:22728
is_a: GO:0016785 ! selenotransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0004126
name: cytidine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+." [EC:3.5.4.5]
synonym: "(deoxy)cytidine deaminase activity" EXACT [EC:3.5.4.5]
synonym: "cytidine aminohydrolase activity" RELATED [EC:3.5.4.5]
synonym: "cytosine nucleoside deaminase activity" RELATED [EC:3.5.4.5]
synonym: "deoxycytidine deaminase activity" RELATED []
xref: EC:3.5.4.5
xref: Reactome:R-HSA-73608 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)"
xref: Reactome:R-HSA-83677 "C4 deamination of cytidine"
xref: Reactome:R-HSA-9817513 "AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine"
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004127
name: (d)CMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.25]
synonym: "ATP:CMP phosphotransferase activity" RELATED [EC:2.7.4.14]
synonym: "CMP kinase activity" NARROW [EC:2.7.4.14]
synonym: "CTP:CMP phosphotransferase activity" RELATED [EC:2.7.4.14]
synonym: "cytidine monophosphate kinase activity" RELATED [EC:2.7.4.14]
synonym: "dCMP kinase activity" NARROW [EC:2.7.4.25]
synonym: "deoxycytidine monophosphokinase activity" RELATED [EC:2.7.4.25]
synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.25]
xref: EC:2.7.4.25
is_a: GO:0050145 ! nucleoside monophosphate kinase activity

[Term]
id: GO:0004128
name: cytochrome-b5 reductase activity, acting on NAD(P)H
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2]
synonym: "cytochrome b5 reductase activity" RELATED [EC:1.6.2.2]
synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" RELATED [EC:1.6.2.2]
synonym: "NADH 5alpha-reductase activity" RELATED [EC:1.6.2.2]
synonym: "NADH-cytochrome b5 reductase activity" RELATED [EC:1.6.2.2]
synonym: "NADH-cytochrome-b5 reductase activity" RELATED [EC:1.6.2.2]
synonym: "NADH-ferricytochrome b5 oxidoreductase activity" RELATED [EC:1.6.2.2]
synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" RELATED [EC:1.6.2.2]
synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" RELATED [EC:1.6.2.2]
xref: EC:1.6.2.2
xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN
xref: Reactome:R-HSA-198824 "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme"
xref: Reactome:R-HSA-6806831 "CYB5Rs reduce MetHb to HbA"
xref: RHEA:46680
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0004129
name: cytochrome-c oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [RHEA:11436]
comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
synonym: "aa3-type cytochrome c oxidase" NARROW [EC:7.1.1.9]
synonym: "ba3-type cytochrome c oxidase" NARROW [EC:7.1.1.9]
synonym: "caa3-type cytochrome c oxidase" NARROW [EC:7.1.1.9]
synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:7.1.1.9]
synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:7.1.1.9]
synonym: "cytochrome a3 activity" NARROW [EC:7.1.1.9]
synonym: "cytochrome aa3 activity" NARROW [EC:7.1.1.9]
synonym: "cytochrome c oxidase activity" EXACT []
synonym: "cytochrome oxidase activity" RELATED [EC:7.1.1.9]
synonym: "indophenol oxidase" NARROW []
synonym: "indophenolase" NARROW []
synonym: "Warburg's respiratory enzyme activity" RELATED [EC:7.1.1.9]
xref: EC:7.1.1.9
xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN
xref: Reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen"
xref: RHEA:11436
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0004130
name: cytochrome-c peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5]
synonym: "apocytochrome c peroxidase activity" RELATED [EC:1.11.1.5]
synonym: "cytochrome c peroxidase activity" RELATED [EC:1.11.1.5]
synonym: "cytochrome c-551 peroxidase activity" RELATED [EC:1.11.1.5]
synonym: "cytochrome c-H2O oxidoreductase activity" RELATED [EC:1.11.1.5]
synonym: "cytochrome peroxidase activity" RELATED [EC:1.11.1.5]
synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5]
xref: EC:1.11.1.5
xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN
xref: RHEA:16581
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004131
name: cytosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1]
synonym: "cytosine aminohydrolase activity" RELATED [EC:3.5.4.1]
synonym: "isocytosine deaminase activity" RELATED [EC:3.5.4.1]
xref: EC:3.5.4.1
xref: MetaCyc:CYTDEAM-RXN
xref: RHEA:20605
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004132
name: dCMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12]
synonym: "dCMP aminohydrolase activity" RELATED [EC:3.5.4.12]
synonym: "deoxy-CMP-deaminase activity" RELATED [EC:3.5.4.12]
synonym: "deoxycytidine monophosphate deaminase activity" RELATED [EC:3.5.4.12]
synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" RELATED [EC:3.5.4.12]
synonym: "deoxycytidine-5'-phosphate deaminase activity" RELATED [EC:3.5.4.12]
synonym: "deoxycytidylate aminohydrolase activity" RELATED [EC:3.5.4.12]
synonym: "deoxycytidylate deaminase activity" RELATED [EC:3.5.4.12]
xref: EC:3.5.4.12
xref: MetaCyc:DCMP-DEAMINASE-RXN
xref: Reactome:R-HSA-73596 "dCMP + H2O => dUMP + NH4+"
xref: RHEA:22924
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004133
name: glycogen debranching enzyme activity
namespace: molecular_function
def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0004134
name: 4-alpha-glucanotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25]
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" RELATED [EC:2.4.1.25]
synonym: "amylomaltase activity" RELATED [EC:2.4.1.25]
synonym: "D-enzyme activity" RELATED [EC:2.4.1.25]
synonym: "debranching enzyme maltodextrin glycosyltransferase activity" RELATED [EC:2.4.1.25]
synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25]
synonym: "dextrin transglycosylase activity" RELATED [EC:2.4.1.25]
synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25]
synonym: "oligo-1,4-1,4-glucantransferase activity" RELATED [EC:2.4.1.25]
xref: EC:2.4.1.25
xref: Reactome:R-HSA-71552 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin"
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0004135
name: amylo-alpha-1,6-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33]
synonym: "amylo-1,6-glucosidase activity" EXACT []
synonym: "amylopectin 1,6-glucosidase activity" RELATED [EC:3.2.1.33]
synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33]
synonym: "dextrin-1,6-glucosidase activity" RELATED [EC:3.2.1.33]
synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" RELATED [EC:3.2.1.33]
xref: EC:3.2.1.33
xref: MetaCyc:3.2.1.33-RXN
xref: Reactome:R-HSA-71593 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose"
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004136
name: deoxyadenosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+." [EC:2.7.1.76, RHEA:23452]
synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.76]
synonym: "deoxyadenosine kinase (phosphorylating)" RELATED [EC:2.7.1.76]
synonym: "purine-deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.76]
xref: EC:2.7.1.76
xref: KEGG_REACTION:R02089
xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN
xref: RHEA:23452
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004137
name: deoxycytidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74]
synonym: "2'-deoxycytidine kinase activity" RELATED [EC:2.7.1.74]
synonym: "Ara-C kinase activity" RELATED [EC:2.7.1.74]
synonym: "arabinofuranosylcytosine kinase activity" RELATED [EC:2.7.1.74]
synonym: "deoxycytidine kinase (phosphorylating)" RELATED [EC:2.7.1.74]
synonym: "deoxycytidine-cytidine kinase activity" RELATED [EC:2.7.1.74]
synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.74]
xref: EC:2.7.1.74
xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN
xref: RHEA:20061
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004138
name: deoxyguanosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+." [EC:2.7.1.113, RHEA:19201]
synonym: "(dihydroxypropoxymethyl)guanine kinase activity" RELATED [EC:2.7.1.113]
synonym: "2'-deoxyguanosine kinase activity" RELATED [EC:2.7.1.113]
synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.113]
synonym: "deoxyguanosine kinase (phosphorylating)" RELATED [EC:2.7.1.113]
synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.113]
xref: EC:2.7.1.113
xref: KEGG_REACTION:R01967
xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN
xref: RHEA:19201
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004139
name: deoxyribose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12821]
synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" RELATED [EC:4.1.2.4]
synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" RELATED [EC:4.1.2.4]
synonym: "2-deoxyribose-5-phosphate aldolase activity" RELATED [EC:4.1.2.4]
synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4]
synonym: "deoxyribose-5-phosphate aldolase activity" RELATED [EC:4.1.2.4]
synonym: "phosphodeoxyriboaldolase activity" RELATED [EC:4.1.2.4]
xref: EC:4.1.2.4
xref: KEGG_REACTION:R01066
xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN
xref: Reactome:R-HSA-6787321 "DERA cleaves dR5P to GA3P and CH3CHO"
xref: RHEA:12821
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004140
name: dephospho-CoA kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+." [EC:2.7.1.24, RHEA:18245]
synonym: "3'-dephospho-CoA kinase activity" RELATED [EC:2.7.1.24]
synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" RELATED [EC:2.7.1.24]
synonym: "dephosphocoenzyme A kinase (phosphorylating)" RELATED [EC:2.7.1.24]
synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24]
xref: EC:2.7.1.24
xref: KEGG_REACTION:R00130
xref: MetaCyc:DEPHOSPHOCOAKIN-RXN
xref: Reactome:R-HSA-196773 "COASY phosphorylates DP-CoA"
xref: Reactome:R-HSA-9837337 "DCAKD phosphorylates DP-CoA"
xref: RHEA:18245
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004141
name: dethiobiotin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate." [EC:6.3.3.3, RHEA:15805]
synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.3]
synonym: "desthiobiotin synthase activity" RELATED [EC:6.3.3.3]
synonym: "DTB synthetase activity" RELATED [EC:6.3.3.3]
xref: EC:6.3.3.3
xref: KEGG_REACTION:R03182
xref: MetaCyc:DETHIOBIOTIN-SYN-RXN
xref: RHEA:15805
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0004142
name: diacylglycerol cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2, RHEA:32939]
synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "alkylacylglycerol choline phosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "alkylacylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "CDP-choline diglyceride phosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "CPT" RELATED [EC:2.7.8.2]
synonym: "cytidine diphosphocholine glyceride transferase activity" RELATED [EC:2.7.8.2]
synonym: "cytidine diphosphorylcholine diglyceride transferase activity" RELATED [EC:2.7.8.2]
synonym: "diacylglycerol choline phosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "phosphocholine diacylglyceroltransferase activity" RELATED [EC:2.7.8.2]
synonym: "phosphorylcholine--glyceride transferase activity" RELATED [EC:2.7.8.2]
synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
xref: EC:2.7.8.2
xref: MetaCyc:RXN-5781
xref: Reactome:R-HSA-1482961 "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane"
xref: Reactome:R-HSA-1482973 "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane"
xref: RHEA:32939
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0004143
name: ATP-dependent diacylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+." [GOC:elh, RHEA:10272]
synonym: "DGK activity" RELATED [EC:2.7.1.107]
synonym: "diacylglycerol kinase activity" BROAD []
synonym: "diacylglycerol kinase activity (ATP)" EXACT []
synonym: "diglyceride kinase activity" BROAD [EC:2.7.1.107]
xref: EC:2.7.1.107
xref: MetaCyc:DIACYLGLYKIN-RXN
xref: Reactome:R-HSA-426240 "DAG kinase produces phosphatidic acid from DAG"
xref: RHEA:10272
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004144
name: diacylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]
synonym: "1,2-diacylglycerol acyltransferase activity" RELATED [EC:2.3.1.20]
synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" RELATED [EC:2.3.1.20]
synonym: "diacylglycerol acyltransferase activity" RELATED [EC:2.3.1.20]
synonym: "diglyceride acyltransferase activity" RELATED [EC:2.3.1.20]
synonym: "diglyceride O-acyltransferase activity" RELATED [EC:2.3.1.20]
synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" RELATED [EC:2.3.1.20]
xref: EC:2.3.1.20
xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
xref: Reactome:R-HSA-1482889 "DAG is acylated to TAG by DGAT1/2"
xref: Reactome:R-HSA-549192 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]"
xref: Reactome:R-HSA-75900 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]"
xref: Reactome:R-HSA-8848580 "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG"
xref: RHEA:10868
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0004145
name: diamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57]
synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" RELATED [EC:2.3.1.57]
synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW []
synonym: "diamine acetyltransferase activity" EXACT []
synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW []
synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57]
synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine N1-acetyltransferase activity" RELATED [EC:2.3.1.57]
synonym: "spermidine/spermine N1-acetyltransferase activity" RELATED [EC:2.3.1.57]
synonym: "spermine acetyltransferase" NARROW []
synonym: "spermine N(1)-acetyltransferase" NARROW []
synonym: "spermine N-acetyltransferase" RELATED []
xref: EC:2.3.1.57
xref: MetaCyc:DIAMACTRANS-RXN
xref: Reactome:R-HSA-351207 "Spermine  => N-acetylated spermine"
xref: Reactome:R-HSA-351208 "Spermidine  => N-acetylated spermidine"
xref: RHEA:25181
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004146
name: dihydrofolate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]
synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.3]
synonym: "7,8-dihydrofolate reductase activity" RELATED [EC:1.5.1.3]
synonym: "DHFR" RELATED [EC:1.5.1.3]
synonym: "dihydrofolate reductase:thymidylate synthase activity" RELATED [EC:1.5.1.3]
synonym: "dihydrofolate reduction" EXACT []
synonym: "dihydrofolic acid reductase activity" RELATED [EC:1.5.1.3]
synonym: "dihydrofolic reductase activity" RELATED [EC:1.5.1.3]
synonym: "folic acid reductase activity" RELATED [EC:1.5.1.3]
synonym: "folic reductase activity" RELATED [EC:1.5.1.3]
synonym: "NADPH-dihydrofolate reductase activity" RELATED [EC:1.5.1.3]
synonym: "pteridine reductase:dihydrofolate reductase activity" RELATED [EC:1.5.1.3]
synonym: "tetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.3]
synonym: "thymidylate synthetase-dihydrofolate reductase activity" RELATED [EC:1.5.1.3]
xref: EC:1.5.1.3
xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN
xref: Reactome:R-HSA-1497794 "Salvage - BH2 is reduced to BH4 by DHFR"
xref: RHEA:15009
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004148
name: dihydrolipoyl dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4]
synonym: "dehydrolipoate dehydrogenase activity" RELATED [EC:1.8.1.4]
synonym: "diaphorase activity" RELATED [EC:1.8.1.4]
synonym: "dihydrolipoamide dehydrogenase activity" RELATED [EC:1.8.1.4]
synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4]
synonym: "dihydrolipoamide:NAD+ oxidoreductase" RELATED [EC:1.8.1.4]
synonym: "dihydrolipoic dehydrogenase activity" RELATED [EC:1.8.1.4]
synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4]
synonym: "dihydrothioctic dehydrogenase activity" RELATED [EC:1.8.1.4]
synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4]
synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4]
synonym: "L-protein activity" RELATED [EC:1.8.1.4]
synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4]
synonym: "LDP-Val activity" NARROW [EC:1.8.1.4]
synonym: "lipoamide dehydrogenase (NADH) activity" RELATED [EC:1.8.1.4]
synonym: "lipoamide oxidoreductase (NADH) activity" RELATED [EC:1.8.1.4]
synonym: "lipoamide reductase (NADH) activity" RELATED [EC:1.8.1.4]
synonym: "lipoamide reductase activity" RELATED [EC:1.8.1.4]
synonym: "lipoate dehydrogenase activity" RELATED [EC:1.8.1.4]
synonym: "lipoic acid dehydrogenase activity" RELATED [EC:1.8.1.4]
synonym: "lipoyl dehydrogenase activity" RELATED [EC:1.8.1.4]
synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED [EC:1.8.1.4]
synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED [EC:1.8.1.4]
xref: EC:1.8.1.4
xref: MetaCyc:1.8.1.4-RXN
xref: Reactome:R-HSA-1222412 "LpdC dimer reactivates DlaT"
xref: Reactome:R-HSA-5694018 "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate"
xref: Reactome:R-HSA-9853499 "DLD dimer dehydrogenates dihydrolipoyl"
xref: Reactome:R-HSA-9858589 "DLD dimer dehydrogenates dihydrolipoyl"
xref: Reactome:R-HSA-9859172 "DLD dimer dehydrogenates dihydrolipoyl"
xref: Reactome:R-HSA-9861616 "DLD dimer dehydrogenates dihydrolipoyl"
xref: Reactome:R-HSA-9907572 "Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT"
xref: RHEA:15045
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0004149
name: dihydrolipoyllysine-residue succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61]
synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT []
synonym: "dihydrolipoamide succinyltransferase activity" RELATED [EC:2.3.1.61]
synonym: "dihydrolipoic transsuccinylase activity" RELATED [EC:2.3.1.61]
synonym: "dihydrolipolyl transsuccinylase activity" RELATED [EC:2.3.1.61]
synonym: "dihydrolipoyl transsuccinylase activity" RELATED [EC:2.3.1.61]
synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" RELATED [EC:2.3.1.61]
synonym: "lipoate succinyltransferase (Escherichia coli) activity" RELATED [EC:2.3.1.61]
synonym: "lipoate succinyltransferase activity" RELATED [EC:2.3.1.61]
synonym: "lipoic transsuccinylase activity" RELATED [EC:2.3.1.61]
synonym: "lipoyl transsuccinylase activity" RELATED [EC:2.3.1.61]
synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" RELATED [EC:2.3.1.61]
synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" RELATED [EC:2.3.1.61]
synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" RELATED [EC:2.3.1.61]
synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" RELATED [EC:2.3.1.61]
xref: EC:2.3.1.61
xref: Reactome:R-HSA-9853512 "DLST transfers succinyl to CoA"
xref: Reactome:R-HSA-9858590 "DLST transfers glutaryl to CoA"
xref: RHEA:15213
is_a: GO:0016751 ! S-succinyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004150
name: dihydroneopterin aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25]
synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" RELATED [EC:4.1.2.25]
synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" RELATED [EC:4.1.2.25]
xref: EC:4.1.2.25
xref: MetaCyc:H2NEOPTERINALDOL-RXN
xref: RHEA:10540
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004151
name: dihydroorotase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+." [EC:3.5.2.3, RHEA:24296]
synonym: "(S)-dihydroorotate amidohydrolase activity" RELATED [EC:3.5.2.3]
synonym: "carbamoylaspartic dehydrase activity" RELATED [EC:3.5.2.3]
synonym: "DHOase activity" RELATED [EC:3.5.2.3]
synonym: "dihydroorotate hydrolase activity" RELATED [EC:3.5.2.3]
xref: EC:3.5.2.3
xref: KEGG_REACTION:R01993
xref: MetaCyc:DIHYDROOROT-RXN
xref: Reactome:R-HSA-73571 "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO"
xref: RHEA:24296
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004152
name: dihydroorotate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [RHEA:18073]
xref: KEGG_REACTION:R01868
xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-73569 "DHODH:FMN oxidises (S)-DHO to orotate"
xref: RHEA:18073
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0004153
name: dihydropterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [GOC:jl, PMID:19567870, PMID:38786926]
xref: MetaCyc:RXN-15261
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004154
name: dihydropterin oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:38786926, PMID:6815189]
xref: MetaCyc:RXN-15269
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0004155
name: 6,7-dihydropteridine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34]
synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" RELATED [EC:1.5.1.34]
synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" RELATED [EC:1.5.1.34]
synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" RELATED [EC:1.5.1.34]
synonym: "DHPR activity" RELATED [EC:1.5.1.34]
synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.34]
synonym: "dihydropteridine reductase (NADH) activity" RELATED [EC:1.5.1.34]
synonym: "dihydropteridine reductase activity" EXACT []
synonym: "dihydropteridine reduction" RELATED []
synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" RELATED [EC:1.5.1.34]
synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" RELATED [EC:1.5.1.34]
synonym: "NADH-dihydropteridine reductase activity" RELATED [EC:1.5.1.34]
synonym: "NADPH-dihydropteridine reductase activity" RELATED [EC:1.5.1.34]
synonym: "NADPH-specific dihydropteridine reductase activity" RELATED [EC:1.5.1.34]
xref: EC:1.5.1.34
xref: MetaCyc:1.5.1.34-RXN
xref: Reactome:R-HSA-71130 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004156
name: dihydropteroate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15]
synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" RELATED [EC:2.5.1.15]
synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" RELATED [EC:2.5.1.15]
synonym: "7,8-dihydropteroate synthase activity" RELATED [EC:2.5.1.15]
synonym: "7,8-dihydropteroate synthetase activity" RELATED [EC:2.5.1.15]
synonym: "7,8-dihydropteroic acid synthetase activity" RELATED [EC:2.5.1.15]
synonym: "DHPS activity" RELATED [EC:2.5.1.15]
synonym: "dihydropteroate diphosphorylase activity" RELATED [EC:2.5.1.15]
synonym: "dihydropteroate pyrophosphorylase activity" RELATED [EC:2.5.1.15]
synonym: "dihydropteroate synthetase activity" RELATED [EC:2.5.1.15]
synonym: "dihydropteroic synthetase activity" RELATED [EC:2.5.1.15]
xref: EC:2.5.1.15
xref: MetaCyc:H2PTEROATESYNTH-RXN
xref: RHEA:19949
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004157
name: dihydropyrimidinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2]
synonym: "5,6-dihydropyrimidine amidohydrolase activity" RELATED [EC:3.5.2.2]
synonym: "D-hydantoinase activity" RELATED [EC:3.5.2.2]
synonym: "hydantoin peptidase activity" RELATED [EC:3.5.2.2]
synonym: "hydantoinase activity" RELATED [EC:3.5.2.2]
synonym: "hydropyrimidine hydrase activity" RELATED [EC:3.5.2.2]
synonym: "pyrimidine hydrase activity" RELATED [EC:3.5.2.2]
xref: EC:3.5.2.2
xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN
xref: Reactome:R-HSA-73589 "5,6-dihydrouracil + H2O => beta-ureidopropionate"
xref: Reactome:R-HSA-73618 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate"
xref: RHEA:16121
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004158
name: obsolete dihydroorotate oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (S)-dihydroorotate + O2 = H2O2 + orotate." [GOC:curators]
comment: There appears to be no evidence for this reaction. The original EC used for this reaction was not appropriate.
synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" RELATED []
synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" RELATED []
is_obsolete: true

[Term]
id: GO:0004159
name: dihydropyrimidine dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+." [PMID:23150645]
synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" RELATED []
synonym: "dihydrothymine dehydrogenase (NAD+) activity" NARROW []
synonym: "dihydrouracil dehydrogenase (NAD+) activity" NARROW []
synonym: "pyrimidine reductase activity" RELATED []
synonym: "thymine reductase activity" NARROW []
synonym: "uracil reductase activity" NARROW []
xref: EC:1.3.1.1
xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004160
name: dihydroxy-acid dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [RHEA:24809]
synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" RELATED [EC:4.2.1.9]
synonym: "2,3-dihydroxy-acid hydro-lyase activity" RELATED [EC:4.2.1.9]
synonym: "2,3-dihydroxyisovalerate dehydratase activity" RELATED [EC:4.2.1.9]
synonym: "acetohydroxyacid dehydratase activity" RELATED [EC:4.2.1.9]
synonym: "alpha,beta-dihydroxyacid dehydratase activity" RELATED [EC:4.2.1.9]
synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" RELATED [EC:4.2.1.9]
synonym: "DHAD" RELATED [EC:4.2.1.9]
synonym: "dihydroxy acid dehydrase activity" RELATED [EC:4.2.1.9]
xref: EC:4.2.1.9
xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN
xref: RHEA:24809
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004161
name: dimethylallyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate." [RHEA:22408]
comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.1]
synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" RELATED [EC:2.5.1.1]
synonym: "dimethylallyltransferase activity" EXACT []
synonym: "diprenyltransferase activity" RELATED [EC:2.5.1.1]
synonym: "DMAPP:IPP-dimethylallyltransferase activity" RELATED [EC:2.5.1.1]
synonym: "geranyl diphosphate synthase activity" EXACT []
synonym: "geranyl pyrophosphate synthase activity" RELATED [EC:2.5.1.1]
synonym: "geranyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1]
synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1]
synonym: "trans-farnesyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1]
xref: EC:2.5.1.1
xref: MetaCyc:GPPSYN-RXN
xref: Reactome:R-HSA-191322 "FDPS dimer transfers IPPP to DMAPP"
xref: Reactome:R-HSA-9717834 "GGPS1 hexamer transfers IPPP to DMAPP"
xref: RHEA:22408
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0004162
name: obsolete dimethylnitrosamine demethylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "N-nitrosodimethylamine demethylase activity" EXACT []
is_obsolete: true
consider: GO:0004497
consider: GO:0016491

[Term]
id: GO:0004163
name: diphosphomevalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23732]
synonym: "5-pyrophosphomevalonate decarboxylase activity" RELATED [EC:4.1.1.33]
synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" RELATED [EC:4.1.1.33]
synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" RELATED [EC:4.1.1.33]
synonym: "mevalonate 5-diphosphate decarboxylase activity" RELATED [EC:4.1.1.33]
synonym: "mevalonate diphosphate decarboxylase activity" RELATED [EC:4.1.1.33]
synonym: "mevalonate pyrophosphate decarboxylase activity" RELATED [EC:4.1.1.33]
synonym: "mevalonate-5-pyrophosphate decarboxylase activity" RELATED [EC:4.1.1.33]
synonym: "pyrophosphomevalonate decarboxylase activity" RELATED [EC:4.1.1.33]
synonym: "pyrophosphomevalonic acid decarboxylase activity" RELATED [EC:4.1.1.33]
xref: EC:4.1.1.33
xref: KEGG_REACTION:R01121
xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN
xref: Reactome:R-HSA-191414 "MVD decarboxylates MVA5PP to IPPP"
xref: RHEA:23732
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004164
name: diphthine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine." [PMID:15485916, PMID:20873788, PMID:3042777, RHEA:36415]
comment: This activity is present in archae and produces the trimethylated product diphthine, which is converted into diphthamide by diphthine-ammonia ligase activity ; GO:0017178 (EC:6.3.1.14). Note that this is different from the eukaryotic enzyme diphthine methyl ester synthase activity ; GO:0141133 (EC:2.1.1.314), which produces diphthine methyl ester.
synonym: "diphthine methyltransferase activity" RELATED [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" RELATED [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" RELATED [EC:2.1.1.98]
xref: EC:2.1.1.98
xref: MetaCyc:RXN-14326
xref: RHEA:36415
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004165
name: delta(3)-delta(2)-enoyl-CoA isomerase activity
namespace: molecular_function
alt_id: GO:0008461
def: "Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA." [RHEA:45900]
synonym: "3,2-trans-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8]
synonym: "acetylene-allene isomerase activity" RELATED [EC:5.3.3.8]
synonym: "delta(3),delta(2)-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8]
synonym: "delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8]
synonym: "delta3,delta2-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8]
synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" EXACT [EC:5.3.3.8]
synonym: "delta3-delta2 enoyl-CoA isomerase activity" EXACT []
synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" NARROW [EC:5.3.3.8]
synonym: "dodecenoyl-CoA D-isomerase activity" NARROW []
synonym: "dodecenoyl-CoA delta-isomerase activity" NARROW []
synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" NARROW [EC:5.3.3.8]
synonym: "dodecenoyl-CoA isomerase activity" RELATED [EC:5.3.3.8]
xref: EC:5.3.3.8
xref: Reactome:R-HSA-109338 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA"
xref: Reactome:R-HSA-6809808 "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA"
xref: RHEA:45900
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004166
name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0004101
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153]
synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153]
synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153]
synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153]
synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.153]
synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153]
synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153]
xref: EC:2.4.1.153
xref: MetaCyc:2.4.1.153-RXN
xref: RHEA:14693
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004167
name: dopachrome isomerase activity
namespace: molecular_function
alt_id: GO:0048059
def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13041]
synonym: "DCF activity" RELATED [EC:5.3.3.12]
synonym: "DCT activity" RELATED [EC:5.3.3.12]
synonym: "dopachrome conversion activity" BROAD []
synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12]
synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" RELATED [EC:5.3.3.12]
synonym: "dopachrome delta-isomerase activity" EXACT []
synonym: "dopachrome delta7,Delta2-isomerase activity" RELATED [EC:5.3.3.12]
synonym: "dopachrome keto-enol isomerase activity" RELATED [EC:5.3.3.12]
synonym: "dopachrome oxidoreductase activity" RELATED [EC:5.3.3.12]
synonym: "dopachrome rearranging enzyme activity" RELATED [EC:5.3.3.12]
synonym: "dopachrome tautomerase activity" RELATED [EC:5.3.3.12]
synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12]
synonym: "L-dopachrome isomerase activity" RELATED [EC:5.3.3.12]
synonym: "L-dopachrome keto-enol isomerase activity" RELATED [EC:5.3.3.12]
synonym: "L-dopachrome-methyl ester tautomerase activity" RELATED [EC:5.3.3.12]
synonym: "TRP activity" RELATED [EC:5.3.3.12]
synonym: "TRP-1" RELATED [EC:5.3.3.12]
synonym: "TRP-2" RELATED [EC:5.3.3.12]
synonym: "TRP2" RELATED [EC:5.3.3.12]
synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12]
synonym: "tyrosinase-related protein 2 activity" RELATED [EC:5.3.3.12]
xref: EC:5.3.3.12
xref: KEGG_REACTION:R03673
xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN
xref: RHEA:13041
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004168
name: dolichol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108]
synonym: "CTP:dolichol O-phosphotransferase activity" RELATED [EC:2.7.1.108]
synonym: "dolichol phosphokinase activity" RELATED [EC:2.7.1.108]
xref: EC:2.7.1.108
xref: MetaCyc:DOLICHOL-KINASE-RXN
xref: Reactome:R-HSA-446195 "DOLK phosphorylates DCHOL to DOLP"
xref: Reactome:R-HSA-4755600 "Defective DOLK does not phosphorylate DCHOL"
xref: RHEA:13133
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004169
name: dolichyl-phosphate-mannose-protein mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]
comment: Note that this activity has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543.
synonym: "dolichol phosphomannose-protein mannosyltransferase activity" RELATED [EC:2.4.1.109]
synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" RELATED [EC:2.4.1.109]
synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT []
synonym: "O-glycoside mannosyltransferase" BROAD []
synonym: "protein O-D-mannosyltransferase activity" RELATED [EC:2.4.1.109]
synonym: "protein O-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.109
xref: MetaCyc:2.4.1.109-RXN
xref: Reactome:R-HSA-5615556 "Defective POMT2 does not transfer Man from Dol-P-Man to DAG1"
xref: Reactome:R-HSA-5615604 "Defective POMT1 does not transfer Man from Dol-P-Man to DAG1"
xref: Reactome:R-HSA-5615637 "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)"
is_a: GO:0000030 ! mannosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004170
name: dUTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate." [RHEA:10248]
subset: goslim_chembl
synonym: "deoxyuridine-triphosphatase activity" RELATED [EC:3.6.1.23]
synonym: "desoxyuridine 5'-triphosphatase activity" RELATED [EC:3.6.1.23]
synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.23]
synonym: "dUTP nucleotidohydrolase activity" RELATED [EC:3.6.1.23]
synonym: "dUTP pyrophosphatase activity" EXACT []
synonym: "dUTPase activity" RELATED [EC:3.6.1.23]
xref: EC:3.6.1.23
xref: KEGG_REACTION:R02100
xref: MetaCyc:DUTP-PYROP-RXN
xref: Reactome:R-HSA-73666 "dUTP + H2O => dUMP + pyrophosphate"
xref: RHEA:10248
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0004171
name: obsolete deoxyhypusine synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46]
comment: This term was made obsolete because it represents a multistep reaction.
synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED []
synonym: "deoxyhypusine synthase activity" EXACT []
is_obsolete: true
consider: GO:0008612
consider: GO:0034038

[Term]
id: GO:0004172
name: obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" EXACT []
is_obsolete: true
consider: GO:0050488

[Term]
id: GO:0004173
name: ecdysone O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15217]
synonym: "acyl-CoA:ecdysone acyltransferase activity" RELATED [EC:2.3.1.139]
synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" RELATED [EC:2.3.1.139]
synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" RELATED [EC:2.3.1.139]
xref: EC:2.3.1.139
xref: KEGG_REACTION:R02375
xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN
xref: RHEA:15217
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004174
name: electron-transferring-flavoprotein dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]." [RHEA:24052]
synonym: "electron transfer flavoprotein dehydrogenase activity" RELATED [EC:1.5.5.1]
synonym: "electron transfer flavoprotein Q oxidoreductase activity" RELATED [EC:1.5.5.1]
synonym: "electron transfer flavoprotein reductase activity" RELATED [EC:1.5.5.1]
synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1]
synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1]
synonym: "ETF dehydrogenase activity" RELATED [EC:1.5.5.1]
synonym: "ETF-QO activity" RELATED [EC:1.5.5.1]
synonym: "ETF-ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1]
synonym: "ETF:ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1]
xref: EC:1.5.5.1
xref: MetaCyc:RXN66-550
xref: Reactome:R-HSA-169270 "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2"
xref: RHEA:24052
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0004175
name: endopeptidase activity
namespace: molecular_function
alt_id: GO:0016809
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
synonym: "elastase activity" RELATED [GOC:krc]
synonym: "endoprotease activity" NARROW []
synonym: "proteasome endopeptidase activity" NARROW []
synonym: "proteinase" NARROW []
xref: Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded"
xref: Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha"
xref: Reactome:R-HSA-1236935 "Proteasomal cleavage of substrate (26S proteasome catalyst)"
xref: Reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen (26S proteasome catalyst)"
xref: Reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex"
xref: Reactome:R-HSA-1433374 "Processing of SCF isoform 1"
xref: Reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome"
xref: Reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1"
xref: Reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins"
xref: Reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin"
xref: Reactome:R-HSA-174203 "SCF-mediated degradation of Emi1"
xref: Reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:R-HSA-180573 "Degradation of ubiquitinated CD4"
xref: Reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G"
xref: Reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome"
xref: Reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2"
xref: Reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain"
xref: Reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex"
xref: Reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34"
xref: Reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome"
xref: Reactome:R-HSA-2213200 "Release of endostatin-like peptides"
xref: Reactome:R-HSA-264458 "Proteasome mediated degradation of COP1"
xref: Reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex"
xref: Reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome"
xref: Reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2"
xref: Reactome:R-HSA-450466 "AUF1:mRNA complex is destroyed"
xref: Reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome"
xref: Reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome"
xref: Reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome"
xref: Reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors"
xref: Reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage"
xref: Reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome"
xref: Reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome"
xref: Reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex"
xref: Reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB"
xref: Reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor"
xref: Reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome"
xref: Reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP"
xref: Reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH"
xref: Reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome"
xref: Reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome"
xref: Reactome:R-HSA-5658430 "NF1 is degraded by the proteasome"
xref: Reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3"
xref: Reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK"
xref: Reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome"
xref: Reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)"
xref: Reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer"
xref: Reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer"
xref: Reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome"
xref: Reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome"
xref: Reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome"
xref: Reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A"
xref: Reactome:R-HSA-74730 "Insulin degradation"
xref: Reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1"
xref: Reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin"
xref: Reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN"
xref: Reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53"
xref: Reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7"
xref: Reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7"
xref: Reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome"
xref: Reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome"
xref: Reactome:R-HSA-8932355 "26S proteasome degrades Ub-NFE2L2"
xref: Reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin"
xref: Reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2"
xref: Reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome"
xref: Reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH"
xref: Reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2"
xref: Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2"
xref: Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)"
xref: Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1"
xref: Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4"
xref: Reactome:R-HSA-9614271 "Autocleavage of ADGRG6"
xref: Reactome:R-HSA-9755303 "26S proteasome degrades HIFalpha"
xref: Reactome:R-HSA-9755306 "ub UBXN7 is degraded by the 26S proteasome"
xref: Reactome:R-HSA-9762096 "Ub,pS335,S338,T NFE2L2 is degraded"
xref: Reactome:R-HSA-983150 "Proteasomal cleavage of substrate"
xref: Reactome:R-HSA-983158 "Trimming of peptides in ER"
xref: Reactome:R-HSA-9839376 "TGFBR3(784-851) degradation"
xref: Reactome:R-HSA-9906017 "Unknown peptidase cleaves UQCRFS1 subunit"
xref: Reactome:R-HSA-9908101 "Maturation of the canonical 20S core particle"
xref: Reactome:R-HSA-9908105 "Maturation of the 20S immunoproteasome core particle"
xref: Reactome:R-HSA-9908108 "Maturation of the 20S thymoproteasome core particle"
xref: Reactome:R-HSA-9908780 "Maturation of the preholospermatoproteasome"
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0004176
name: ATP-dependent peptidase activity
namespace: molecular_function
alt_id: GO:0004280
def: "Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis." [GOC:mah]
synonym: "ATP-dependent proteolysis" RELATED [GOC:mah]
xref: Reactome:R-HSA-9698929 "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex"
xref: Reactome:R-HSA-9838004 "LONP1 degrades mitochondrial inner membrane proteins"
xref: Reactome:R-HSA-9838081 "LONP1 degrades mitochondrial matrix proteins"
xref: Reactome:R-HSA-9838289 "CLPXP degrades mitochondrial matrix proteins"
xref: Reactome:R-HSA-9839059 "AFG3L2:SPG7 degrades SMDT1 (EMRE)"
xref: Reactome:R-HSA-9839105 "AFG3L2 degrades mitochondrial matrix proteins"
xref: Reactome:R-HSA-9839113 "AFG3L2 degrades mitochondrial inner membrane proteins"
xref: Reactome:R-HSA-9839146 "YME1L1 degrades mitochondrial inner membrane proteins"
xref: Reactome:R-HSA-9839751 "YME1L1 degrades mitochondrial intermembrane space proteins"
is_a: GO:0008233 ! peptidase activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0004177
name: aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]
xref: EC:3.4.11.-
xref: https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE
xref: MetaCyc:RXN0-5052
xref: Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles"
xref: Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1"
xref: Reactome:R-HSA-983162 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases"
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0004178
name: obsolete leucyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "leucyl aminopeptidase activity" EXACT []
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0004179
name: obsolete membrane alanyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "membrane alanyl aminopeptidase activity" EXACT []
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0004180
name: carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]
xref: Reactome:R-HSA-1247910 "CNDP2:2Mn2+ dimer hydrolyses CysGly"
xref: Reactome:R-HSA-9753632 "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly"
xref: RHEA:28783
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0004181
name: metallocarboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]
xref: EC:3.4.17.-
xref: Reactome:R-HSA-2022378 "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)"
xref: Reactome:R-HSA-2022379 "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)"
xref: Reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)"
xref: Reactome:R-HSA-8852809 "CPN, CPB2 cleave C3a, C5a"
xref: Reactome:R-HSA-8866105 "CCPs deglutamylate tubulin"
xref: Reactome:R-HSA-8955712 "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer"
xref: Reactome:R-HSA-9023159 "Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87))"
xref: Reactome:R-HSA-9023163 "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)"
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0008235 ! metalloexopeptidase activity

[Term]
id: GO:0004182
name: obsolete carboxypeptidase A activity
namespace: molecular_function
alt_id: GO:0008731
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase A activity" EXACT []
synonym: "carboxypolypeptidase activity" RELATED [EC:3.4.17.1]
synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1]
synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004183
name: obsolete carboxypeptidase E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase E activity" EXACT []
synonym: "carboxypeptidase H activity" EXACT []
synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" RELATED [EC:3.4.17.10]
synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10]
synonym: "enkephalin precursor carboxypeptidase activity" RELATED [EC:3.4.17.10]
synonym: "enkephalin-precursor endopeptidase activity" RELATED [EC:3.4.17.10]
synonym: "insulin granule-associated carboxypeptidase activity" RELATED [EC:3.4.17.10]
synonym: "membrane-bound carboxypeptidase activity" RELATED [EC:3.4.17.10]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004184
name: obsolete lysine carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3]
synonym: "arginine carboxypeptidase activity" RELATED [EC:3.4.17.3]
synonym: "bradykinase activity" RELATED [EC:3.4.17.3]
synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3]
synonym: "carboxypeptidase N activity" EXACT []
synonym: "CPase N" RELATED [EC:3.4.17.3]
synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3]
synonym: "creatinine kinase convertase activity" RELATED [EC:3.4.17.3]
synonym: "hippuryllysine hydrolase activity" RELATED [EC:3.4.17.3]
synonym: "kininase I activity" RELATED [EC:3.4.17.3]
synonym: "kininase Ia" RELATED [EC:3.4.17.3]
synonym: "lysine (arginine) carboxypeptidase activity" EXACT []
synonym: "lysine carboxypeptidase activity" EXACT []
synonym: "lysine(arginine) carboxypeptidase activity" RELATED [EC:3.4.17.3]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3]
synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004185
name: serine-type carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]
synonym: "serine carboxypeptidase activity" EXACT []
xref: EC:3.4.16.-
xref: Reactome:R-HSA-158251 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer"
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity

[Term]
id: GO:0004186
name: obsolete carboxypeptidase C activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase C activity" EXACT []
synonym: "carboxypeptidase Y activity" RELATED [EC:3.4.16.5]
synonym: "cathepsin A activity" NARROW [EC:3.4.16.5]
synonym: "deamidase" RELATED [EC:3.4.16.5]
synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5]
synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5]
synonym: "serine carboxypeptidase I activity" RELATED [EC:3.4.16.5]
synonym: "serine-type carboxypeptidase I activity" RELATED [EC:3.4.16.5]
synonym: "vacuolar carboxypeptidase Y" NARROW []
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004187
name: obsolete carboxypeptidase D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase D activity" EXACT []
synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6]
synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6]
synonym: "carboxypeptidase S1 activity" RELATED [EC:3.4.16.6]
synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6]
synonym: "CPDW-II" RELATED [EC:3.4.16.6]
synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6]
synonym: "KEX1 carboxypeptidase activity" RELATED [EC:3.4.16.6]
synonym: "KEX1 proteinase activity" RELATED [EC:3.4.16.6]
synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6]
synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6]
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004188
name: obsolete serine-type Pro-X carboxypeptidase activity
namespace: molecular_function
alt_id: GO:0008323
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoacylproline carboxypeptidase activity" RELATED [EC:3.4.16.2]
synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW []
synonym: "lysosomal Pro-Xaa carboxypeptidase activity" RELATED [EC:3.4.16.2]
synonym: "PCP" RELATED [EC:3.4.16.2]
synonym: "peptidylprolylamino acid carboxypeptidase activity" RELATED [EC:3.4.16.2]
synonym: "proline carboxypeptidase activity" RELATED [EC:3.4.16.2]
synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2]
synonym: "prolyl carboxypeptidase activity" RELATED [EC:3.4.16.2]
synonym: "serine-type Pro-X carboxypeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004189
name: obsolete tubulinyl-Tyr carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17]
comment: This term was made obsolete because it represents a gene product.
synonym: "brain I carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "carboxypeptidase-tubulin activity" RELATED [EC:3.4.17.17]
synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "TTCPase activity" RELATED [EC:3.4.17.17]
synonym: "tubulin carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "tubulin-tyrosine carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "tubulinyl-Tyr carboxypeptidase activity" EXACT []
synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT []
synonym: "tubulinyltyrosine carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "tyrosinotubulin carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "tyrosyltubulin carboxypeptidase activity" RELATED [EC:3.4.17.17]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004190
name: aspartic-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
synonym: "aspartate protease activity" NARROW [GOC:mah, GOC:vw]
synonym: "aspartic endopeptidase activity" EXACT []
synonym: "aspartic protease activity" NARROW []
synonym: "aspartyl protease activity" NARROW []
synonym: "carboxyl protease activity" NARROW []
xref: EC:3.4.23.-
xref: Reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1"
xref: Reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2"
xref: Reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)"
xref: Reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)"
xref: Reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)"
xref: Reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants"
xref: Reactome:R-HSA-373705 "Caspase cleavage of DCC"
xref: Reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3"
xref: Reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3"
xref: Reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070001 ! aspartic-type peptidase activity

[Term]
id: GO:0004191
name: obsolete barrierpepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35]
comment: This term was made obsolete because it represents a gene product.
synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35]
synonym: "barrier proteinase activity" RELATED [EC:3.4.23.35]
synonym: "barrierpepsin activity" EXACT []
synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004192
name: obsolete cathepsin D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin D activity" EXACT []
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004193
name: obsolete cathepsin E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin D-like acid proteinase activity" RELATED [EC:3.4.23.34]
synonym: "cathepsin D-type proteinase activity" RELATED [EC:3.4.23.34]
synonym: "cathepsin E activity" EXACT []
synonym: "cathepsin E-like acid proteinase activity" RELATED [EC:3.4.23.34]
synonym: "EMAP" RELATED [EC:3.4.23.34]
synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34]
synonym: "non-pepsin proteinase activity" RELATED [EC:3.4.23.34]
synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34]
synonym: "SMP" RELATED [EC:3.4.23.34]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004194
name: obsolete pepsin A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1]
synonym: "fundus-pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1]
synonym: "P I" RELATED [EC:3.4.23.1]
synonym: "P II" RELATED [EC:3.4.23.1]
synonym: "pepsin A activity" EXACT []
synonym: "pepsin activity" BROAD [EC:3.4.23.1]
synonym: "pepsin D" RELATED [EC:3.4.23.1]
synonym: "pepsin fortior" RELATED [EC:3.4.23.1]
synonym: "pepsin R" RELATED [EC:3.4.23.1]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004195
name: obsolete renin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15]
comment: This term was made obsolete because it represents a gene product.
synonym: "angiotensin-forming enzyme activity" RELATED [EC:3.4.23.15]
synonym: "angiotensinogenase activity" RELATED [EC:3.4.23.15]
synonym: "renin activity" EXACT []
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004196
name: obsolete saccharopepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25]
comment: This term was made obsolete because it represents a gene product.
synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "PRA" RELATED [EC:3.4.23.25]
synonym: "proteinase A" RELATED [EC:3.4.23.25]
synonym: "proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25]
synonym: "saccharomyces aspartic proteinase activity" RELATED [EC:3.4.23.25]
synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25]
synonym: "saccharopepsin activity" EXACT []
synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25]
synonym: "yeast proteinase A" RELATED [EC:3.4.23.25]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004197
name: cysteine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
synonym: "caspase activity" NARROW [GOC:mtg_apoptosis]
synonym: "lysosomal cysteine-type endopeptidase" NARROW []
synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis]
synonym: "thiol endopeptidase activity" EXACT []
xref: EC:3.4.22.-
xref: Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome"
xref: Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9"
xref: Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome"
xref: Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle"
xref: Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage"
xref: Reactome:R-HSA-139952 "Caspase-8 processing in the DISC"
xref: Reactome:R-HSA-1678920 "TLR processing at low pH"
xref: Reactome:R-HSA-1678981 "TLR9 processing at neutral pH"
xref: Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1"
xref: Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta"
xref: Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin"
xref: Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1"
xref: Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin"
xref: Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)"
xref: Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau"
xref: Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus"
xref: Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3"
xref: Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1"
xref: Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin"
xref: Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1"
xref: Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2"
xref: Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha"
xref: Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3"
xref: Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3"
xref: Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1"
xref: Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin"
xref: Reactome:R-HSA-202947 "Caspase mediated cleavage of APC"
xref: Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1"
xref: Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55"
xref: Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin"
xref: Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin"
xref: Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3"
xref: Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)"
xref: Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212"
xref: Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta"
xref: Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22"
xref: Reactome:R-HSA-2130349 "Generation of CLIP from lip10"
xref: Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10"
xref: Reactome:R-HSA-2130706 "MHC class II antigen processing"
xref: Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex"
xref: Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A"
xref: Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1"
xref: Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC"
xref: Reactome:R-HSA-350158 "LGMN degrades GC"
xref: Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)"
xref: Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)"
xref: Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK"
xref: Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk"
xref: Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2"
xref: Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin"
xref: Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2"
xref: Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31"
xref: Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3"
xref: Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1"
xref: Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin"
xref: Reactome:R-HSA-352268 "Cleavage of Satb1"
xref: Reactome:R-HSA-418845 "Activation of caspase-3"
xref: Reactome:R-HSA-418846 "Caspase cleavage of UNC5A"
xref: Reactome:R-HSA-418852 "Caspase cleavage of UNC5B"
xref: Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1"
xref: Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8"
xref: Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases"
xref: Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor"
xref: Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4"
xref: Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4"
xref: Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin"
xref: Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37"
xref: Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex"
xref: Reactome:R-HSA-933532 "Processing of caspases"
xref: Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3"
xref: Reactome:R-HSA-9647632 "CASP3 cleaves GSDME"
xref: Reactome:R-HSA-9647680 "CASP1 cleaves GSDMD"
xref: Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins"
xref: Reactome:R-HSA-9684273 "3CLp cleaves pp1a"
xref: Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11"
xref: Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4"
xref: Reactome:R-HSA-9684336 "nsp1-4 cleaves itself"
xref: Reactome:R-HSA-9684340 "3CLp cleaves pp1ab"
xref: Reactome:R-HSA-9684351 "pp1a cleaves itself"
xref: Reactome:R-HSA-9684352 "nsp3-4 cleaves itself"
xref: Reactome:R-HSA-9686088 "CASP3 cleaves GSDMD"
xref: Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8"
xref: Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8"
xref: Reactome:R-HSA-9694338 "nsp1-4 cleaves itself"
xref: Reactome:R-HSA-9694377 "pp1a cleaves itself"
xref: Reactome:R-HSA-9694441 "3CLp cleaves pp1a"
xref: Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11"
xref: Reactome:R-HSA-9694601 "nsp3-4 cleaves itself"
xref: Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4"
xref: Reactome:R-HSA-9694732 "3CLp cleaves pp1ab"
xref: Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)"
xref: Reactome:R-HSA-9710101 "CASP4, CASP5 cleave GSDMD"
xref: Reactome:R-HSA-9729704 "SARS-CoV-2 3CLpro dimer cleaves TAB1"
xref: Reactome:R-HSA-9729730 "SARS-CoV-2 nsp3 cleaves IRF3"
xref: Reactome:R-HSA-9729741 "SARS-CoV-2 3CLpro dimer cleaves NLRP12"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008234 ! cysteine-type peptidase activity

[Term]
id: GO:0004198
name: calcium-dependent cysteine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
synonym: "calpain activity" NARROW []
xref: Reactome:R-HSA-8848658 "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins"
xref: Reactome:R-HSA-8863012 "Calpain cleaves p35 to p25"
xref: Reactome:R-HSA-9855106 "Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)"
xref: Reactome:R-HSA-9861485 "Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)"
is_a: GO:0004197 ! cysteine-type endopeptidase activity

[Term]
id: GO:0004200
name: obsolete signaling (initiator) caspase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes biological process information.
synonym: "signaling (initiator) caspase activity" EXACT []
synonym: "signalling (initiator) caspase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197
consider: GO:0006915

[Term]
id: GO:0004201
name: obsolete caspase-1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-1 activity" EXACT []
synonym: "ICE" BROAD []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004202
name: obsolete caspase-2 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-2 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004203
name: obsolete caspase-4 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-4 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004204
name: obsolete caspase-5 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-5 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004205
name: obsolete caspase-8 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-8 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004206
name: obsolete caspase-10 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-10 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004207
name: obsolete effector caspase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes biological process information.
synonym: "effector caspase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197
consider: GO:0006915

[Term]
id: GO:0004208
name: obsolete caspase-3 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-3 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004209
name: obsolete caspase-6 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-6 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004210
name: obsolete caspase-7 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-7 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004211
name: obsolete caspase-9 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-9 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004212
name: obsolete lysosomal cysteine-type endopeptidase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "lysosomal cysteine-type endopeptidase" EXACT []
is_obsolete: true
consider: GO:0004197
consider: GO:0005764

[Term]
id: GO:0004213
name: obsolete cathepsin B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin B activity" EXACT []
synonym: "cathepsin B1 activity" RELATED [EC:3.4.22.1]
synonym: "cathepsin II" RELATED [EC:3.4.22.1]
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004214
name: obsolete dipeptidyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "dipeptidyl-peptidase I activity" EXACT []
is_obsolete: true
consider: GO:0008234
consider: GO:0008239

[Term]
id: GO:0004215
name: obsolete cathepsin H activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16]
comment: This term was made obsolete because it represents a gene product.
synonym: "aleurain activity" RELATED [EC:3.4.22.16]
synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" RELATED [EC:3.4.22.16]
synonym: "cathepsin B3 activity" RELATED [EC:3.4.22.16]
synonym: "cathepsin Ba" RELATED [EC:3.4.22.16]
synonym: "cathepsin BA activity" RELATED [EC:3.4.22.16]
synonym: "cathepsin H activity" EXACT []
synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" RELATED [EC:3.4.22.16]
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004216
name: obsolete cathepsin K activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin K activity" EXACT []
synonym: "cathepsin O activity" RELATED [EC:3.4.22.38]
synonym: "cathepsin O2 activity" RELATED [EC:3.4.22.38]
synonym: "cathepsin X activity" RELATED [EC:3.4.22.38]
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004217
name: obsolete cathepsin L activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15]
comment: This term was made obsolete because it represents a gene product.
synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15]
synonym: "cathepsin L activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004218
name: obsolete cathepsin S activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin S activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004219
name: obsolete pyroglutamyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [GOC:curator]
comment: This term was made obsolete because it represents a gene product.
synonym: "pyroglutamyl-peptidase I activity" EXACT []
is_obsolete: true
consider: GO:0008234
consider: GO:0016920

[Term]
id: GO:0004221
name: obsolete ubiquitin thiolesterase activity
namespace: molecular_function
alt_id: GO:0008577
def: "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
comment: This term was made obsolete because this molecular function does not exist.
synonym: "ubiquitin C-terminal hydrolase activity" RELATED []
synonym: "ubiquitin carboxy-terminal esterase activity" RELATED [EC:3.1.2.15]
synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15]
synonym: "ubiquitin thioesterase activity" RELATED [EC:3.1.2.15]
synonym: "ubiquitin thiolesterase activity" EXACT []
synonym: "ubiquitin-C-terminal-thioester hydrolase activity" RELATED [EC:3.1.2.15]
synonym: "ubiquitinyl hydrolase 1 activity" NARROW []
is_obsolete: true
consider: GO:0004843

[Term]
id: GO:0004222
name: metalloendopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
synonym: "metalloendoprotease activity" NARROW [GOC:mah]
synonym: "metalloendoproteinase activity" NARROW [GOC:mah]
xref: EC:3.4.24.-
xref: Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"
xref: Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"
xref: Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"
xref: Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors"
xref: Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13"
xref: Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2"
xref: Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14"
xref: Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14"
xref: Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14"
xref: Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13"
xref: Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11"
xref: Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13"
xref: Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3"
xref: Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12"
xref: Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2"
xref: Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10"
xref: Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1"
xref: Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9"
xref: Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13"
xref: Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs"
xref: Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2"
xref: Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF"
xref: Reactome:R-HSA-181567 "botC LC cleaves target cell STX1"
xref: Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25"
xref: Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2"
xref: Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25"
xref: Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1"
xref: Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1"
xref: Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25"
xref: Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides"
xref: Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides"
xref: Reactome:R-HSA-2022141 "Prolysyl oxidase activation"
xref: Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12"
xref: Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9"
xref: Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF"
xref: Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15"
xref: Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15"
xref: Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15"
xref: Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13"
xref: Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10"
xref: Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13"
xref: Reactome:R-HSA-2514790 "Elastin degradation by MMP14"
xref: Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14"
xref: Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14"
xref: Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10"
xref: Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14"
xref: Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15"
xref: Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7"
xref: Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15"
xref: Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7"
xref: Reactome:R-HSA-2537499 "Gelatin degradation by MMP19"
xref: Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1"
xref: Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"
xref: Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5"
xref: Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19"
xref: Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14"
xref: Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13"
xref: Reactome:R-HSA-3791319 "NID1 degradation by MMP19"
xref: Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS"
xref: Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4"
xref: Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS"
xref: Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7"
xref: Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14"
xref: Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7"
xref: Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)"
xref: Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15"
xref: Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2"
xref: Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2"
xref: Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2"
xref: Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2"
xref: Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1"
xref: Reactome:R-HSA-5333671 "CLCAs self cleave"
xref: Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding"
xref: Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3"
xref: Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)"
xref: Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1"
xref: Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)"
xref: Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2"
xref: Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3"
xref: Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1"
xref: Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4"
xref: Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3"
xref: Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)"
xref: Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)"
xref: Reactome:R-HSA-8940554 "MMP2 cleaves OPTC"
xref: Reactome:R-HSA-8940561 "MMP7 cleaves OPTC"
xref: Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)"
xref: Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin"
xref: Reactome:R-HSA-8942302 "MMP13 cleaves OPTC"
xref: Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3"
xref: Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)"
xref: Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU"
xref: Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"
xref: Reactome:R-HSA-9624272 "MMPs cleave HB-EGF"
xref: Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer"
xref: Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer"
xref: Reactome:R-HSA-9840408 "OMA1 cleaves DELE1"
xref: Reactome:R-HSA-9840532 "OMA1 self-cleaves"
xref: Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1"
xref: Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008237 ! metallopeptidase activity

[Term]
id: GO:0004226
name: obsolete Gly-X carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4]
synonym: "carboxypeptidase S activity" RELATED [EC:3.4.17.4]
synonym: "Gly-X carboxypeptidase activity" EXACT []
synonym: "Gly-Xaa carboxypeptidase activity" RELATED [EC:3.4.17.4]
synonym: "glycine carboxypeptidase activity" RELATED [EC:3.4.17.4]
synonym: "peptidase alpha" RELATED [EC:3.4.17.4]
synonym: "yeast carboxypeptidase activity" RELATED [EC:3.4.17.4]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004228
name: obsolete gelatinase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "3/4 collagenase activity" RELATED []
synonym: "72 kDa gelatinase type A" RELATED []
synonym: "72-kDa gelatinase activity" NARROW []
synonym: "collagenase IV" RELATED []
synonym: "collagenase type IV" RELATED []
synonym: "gelatinase A activity" EXACT []
synonym: "matrix metalloproteinase 2 activity" RELATED []
synonym: "matrix metalloproteinase 5" RELATED []
synonym: "MMP 2" RELATED []
synonym: "MMP-2" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD []
synonym: "type IV collagenase activity" RELATED []
synonym: "type IV collagenase/gelatinase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004229
name: obsolete gelatinase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "92-kDa gelatinase activity" NARROW []
synonym: "92-kDa type IV collagenase activity" NARROW []
synonym: "95 kDa type IV collagenase/gelatinase activity" RELATED []
synonym: "collagenase IV" RELATED []
synonym: "collagenase type IV" RELATED []
synonym: "gelatinase B activity" EXACT []
synonym: "gelatinase MMP 9" RELATED []
synonym: "macrophage gelatinase activity" NARROW []
synonym: "matrix metalloproteinase 9 activity" RELATED []
synonym: "MMP 9" RELATED []
synonym: "MMP-9" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD []
synonym: "type V collagenase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004230
name: glutamyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7]
synonym: "aminopeptidase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A2" RELATED [EC:3.4.11.7]
synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7]
synonym: "aspartate aminopeptidase activity" RELATED [EC:3.4.11.7]
synonym: "Ca2+-activated glutamate aminopeptidase activity" RELATED [EC:3.4.11.7]
synonym: "glutamyl peptidase activity" RELATED [EC:3.4.11.7]
synonym: "L-aspartate aminopeptidase activity" RELATED [EC:3.4.11.7]
synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7]
xref: EC:3.4.11.7
xref: MetaCyc:3.4.11.7-RXN
is_a: GO:0004177 ! aminopeptidase activity

[Term]
id: GO:0004231
name: obsolete insulysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "IDE" RELATED []
synonym: "insulin protease activity" RELATED []
synonym: "insulin proteinase activity" RELATED []
synonym: "insulin-degrading enzyme activity" RELATED []
synonym: "insulin-degrading neutral proteinase activity" RELATED []
synonym: "insulin-glucagon protease activity" RELATED []
synonym: "insulin-specific protease activity" RELATED []
synonym: "insulinase activity" RELATED []
synonym: "insulysin activity" EXACT []
synonym: "metalloinsulinase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004232
name: obsolete interstitial collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "interstitial collagenase activity" EXACT []
synonym: "matrix metalloproteinase 1" EXACT []
synonym: "MMP-1" EXACT []
synonym: "vertebrate collagenase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004234
name: obsolete macrophage elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "macrophage elastase activity" EXACT []
synonym: "metalloesterase activity" EXACT []
synonym: "MMP-12" EXACT []
is_obsolete: true
consider: GO:0004175
consider: GO:0004222

[Term]
id: GO:0004235
name: obsolete matrilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrilysin activity" EXACT []
synonym: "matrin activity" RELATED []
synonym: "matrix metalloproteinase 7 activity" RELATED []
synonym: "matrix metalloproteinase pump 1" RELATED []
synonym: "metalloproteinase pump-1" RELATED []
synonym: "MMP" RELATED []
synonym: "MMP 7" RELATED []
synonym: "MMP-7" EXACT []
synonym: "PUMP" RELATED []
synonym: "PUMP-1 activity" NARROW []
synonym: "PUMP-1 proteinase activity" RELATED []
synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW []
synonym: "putative metalloproteinase activity" RELATED []
synonym: "uterine metalloendopeptidase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004237
name: obsolete membrane dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "membrane dipeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0004238
name: obsolete meprin A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "endopeptidase-2 activity" BROAD []
synonym: "meprin" RELATED []
synonym: "meprin A activity" EXACT []
synonym: "meprin-a" RELATED []
synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" RELATED []
synonym: "PABA-peptide hydrolase activity" RELATED []
synonym: "PPH" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004239
name: initiator methionyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of N-terminal initiator methionine from peptides." [EC:3.4.11.18]
comment: This term was reinstated from obsolete
synonym: "L-methionine aminopeptidase activity" RELATED [EC:3.4.11.18]
synonym: "MAP" RELATED [EC:3.4.11.18]
synonym: "methionine aminopeptidase activity" RELATED [EC:3.4.11.18]
synonym: "peptidase M activity" RELATED [EC:3.4.11.18]
xref: EC:3.4.11.18
xref: MetaCyc:3.4.11.18-RXN
is_a: GO:0004177 ! aminopeptidase activity

[Term]
id: GO:0004240
name: obsolete mitochondrial processing peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-mitochondrial processing peptidase" NARROW []
synonym: "beta-mitochondrial processing peptidase" NARROW []
synonym: "matrix peptidase" RELATED []
synonym: "matrix processing peptidase" RELATED []
synonym: "matrix processing proteinase" RELATED []
synonym: "mitochondrial processing peptidase activity" EXACT []
synonym: "mitochondrial protein precursor-processing proteinase activity" RELATED []
synonym: "MPP" EXACT []
synonym: "processing enhancing peptidase (for one of two subunits)" RELATED []
synonym: "processing enhancing peptidase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004241
name: obsolete alpha-mitochondrial processing peptidase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-mitochondrial processing peptidase" EXACT []
synonym: "alpha-MPP" EXACT []
is_obsolete: true
consider: GO:0004222
consider: GO:0005739

[Term]
id: GO:0004242
name: obsolete beta-mitochondrial processing peptidase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "beta-mitochondrial processing peptidase" EXACT []
synonym: "beta-MPP" EXACT []
is_obsolete: true
consider: GO:0004222
consider: GO:0005739

[Term]
id: GO:0004243
name: obsolete mitochondrial intermediate peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "MIP" BROAD []
synonym: "mitochondrial intermediate peptidase activity" EXACT []
synonym: "mitochondrial intermediate precursor-processing proteinase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004244
name: obsolete mitochondrial inner membrane peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769]
comment: This term was made obsolete because it represents a gene product.
synonym: "IMP" BROAD []
synonym: "mitochondrial inner membrane peptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0004245
name: obsolete neprilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [GOC:curator]
comment: This term was made obsolete because it represents a gene product.
synonym: "acute lymphoblastic leukemia antigen" RELATED []
synonym: "CALLA" RELATED []
synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED []
synonym: "CALLA antigen" RELATED []
synonym: "CALLA glycoprotein" RELATED []
synonym: "CALLA glycoproteins" RELATED []
synonym: "CD10" RELATED []
synonym: "common acute lymphoblastic leukemia antigen" RELATED []
synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED []
synonym: "endopeptidase 24.11" RELATED []
synonym: "endopeptidase-2 activity" BROAD []
synonym: "enkephalinase activity" RELATED []
synonym: "kidney-brush-border neutral endopeptidase" NARROW []
synonym: "kidney-brush-border neutral peptidase" NARROW []
synonym: "kidney-brush-border neutral proteinase activity" NARROW []
synonym: "membrane metalloendopeptidase activity" NARROW []
synonym: "neprilysin activity" EXACT []
synonym: "neutral endopeptidase 24.11" RELATED []
synonym: "neutral endopeptidase activity" RELATED []
synonym: "neutral metallendopeptidase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004246
name: obsolete peptidyl-dipeptidase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "ACE activity" BROAD []
synonym: "peptidyl-dipeptidase A activity" EXACT []
is_obsolete: true
replaced_by: GO:0008241

[Term]
id: GO:0004247
name: obsolete saccharolysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "oligopeptidase yscD activity" NARROW []
synonym: "proteinase yscD activity" NARROW []
synonym: "saccharolysin activity" EXACT []
synonym: "saccharomyces cerevisiae proteinase yscD" RELATED []
synonym: "yeast cysteine proteinase D activity" NARROW []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004248
name: obsolete stromelysin 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagen-activating protein" RELATED []
synonym: "collagenase activating protein" RELATED []
synonym: "matrix metalloproteinase 3 activity" RELATED []
synonym: "MMP-3" EXACT []
synonym: "neutral proteoglycanase activity" RELATED []
synonym: "procollagenase activator" RELATED []
synonym: "proteoglycanase activity" RELATED []
synonym: "stromelysin" RELATED []
synonym: "stromelysin 1 activity" EXACT []
synonym: "transin activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004249
name: obsolete stromelysin 3 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 11" EXACT []
synonym: "MMP-11" EXACT []
synonym: "stromelysin 3 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004250
name: obsolete aminopeptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminopeptidase I activity" EXACT []
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0004251
name: obsolete X-Pro dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "X-Pro dipeptidase activity" EXACT []
synonym: "Xaa-Pro dipeptidase activity" EXACT []
is_obsolete: true
consider: GO:0008235
consider: GO:0016805

[Term]
id: GO:0004252
name: serine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
subset: goslim_chembl
synonym: "blood coagulation factor activity" RELATED []
synonym: "serine elastase activity" RELATED [GOC:krc]
xref: EC:3.4.21.-
xref: Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them"
xref: Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein"
xref: Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage"
xref: Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides"
xref: Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)"
xref: Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide"
xref: Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)"
xref: Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)"
xref: Reactome:R-HSA-140769 "factor VII -> factor VIIa"
xref: Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)"
xref: Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)"
xref: Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B"
xref: Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin"
xref: Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form"
xref: Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C"
xref: Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin"
xref: Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2"
xref: Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases"
xref: Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases"
xref: Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS"
xref: Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer"
xref: Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)"
xref: Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)"
xref: Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin"
xref: Reactome:R-HSA-158313 "factor XII -> factor XIIa"
xref: Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)"
xref: Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)"
xref: Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin"
xref: Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)"
xref: Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin"
xref: Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)"
xref: Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)"
xref: Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR"
xref: Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)"
xref: Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE"
xref: Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2"
xref: Reactome:R-HSA-1592297 "Full activation of MMP1"
xref: Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)"
xref: Reactome:R-HSA-1592316 "Initial activation of proMMP1"
xref: Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3"
xref: Reactome:R-HSA-1592371 "Initial activation of proMMP3"
xref: Reactome:R-HSA-1592398 "Activation of proMMP8"
xref: Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs"
xref: Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin"
xref: Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X"
xref: Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C"
xref: Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S"
xref: Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX"
xref: Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII"
xref: Reactome:R-HSA-1602458 "Activation of proMMP10"
xref: Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN"
xref: Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1"
xref: Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN"
xref: Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin"
xref: Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7"
xref: Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14"
xref: Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2"
xref: Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs"
xref: Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin"
xref: Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases"
xref: Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3"
xref: Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13"
xref: Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)"
xref: Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3"
xref: Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7"
xref: Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z"
xref: Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6"
xref: Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2"
xref: Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b"
xref: Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b"
xref: Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases"
xref: Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by FURIN"
xref: Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein"
xref: Reactome:R-HSA-173626 "Activation of C1r"
xref: Reactome:R-HSA-173631 "Activation of C1s"
xref: Reactome:R-HSA-173680 "Activation of C5"
xref: Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B"
xref: Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase"
xref: Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein"
xref: Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B"
xref: Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a"
xref: Reactome:R-HSA-186785 "PDGF-AA clevage by Furin"
xref: Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF"
xref: Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH"
xref: Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN"
xref: Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
xref: Reactome:R-HSA-2129357 "Fibrillin C-terminal processing"
xref: Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release"
xref: Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding"
xref: Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding"
xref: Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1"
xref: Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins"
xref: Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding"
xref: Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE"
xref: Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2"
xref: Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE"
xref: Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS"
xref: Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)"
xref: Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1"
xref: Reactome:R-HSA-265301 "Corticotropin cleavage from POMC"
xref: Reactome:R-HSA-3266557 "Factor I cleaves iC3b"
xref: Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG"
xref: Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8"
xref: Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)"
xref: Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS"
xref: Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS"
xref: Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS"
xref: Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1"
xref: Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS"
xref: Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1"
xref: Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs"
xref: Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB"
xref: Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1"
xref: Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP"
xref: Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP"
xref: Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin"
xref: Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin"
xref: Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)"
xref: Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)"
xref: Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)"
xref: Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va"
xref: Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa"
xref: Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein"
xref: Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer"
xref: Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer"
xref: Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer"
xref: Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)"
xref: Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP"
xref: Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5"
xref: Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2"
xref: Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8"
xref: Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5"
xref: Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)"
xref: Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin"
xref: Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin"
xref: Reactome:R-HSA-8874145 "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)"
xref: Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4"
xref: Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3"
xref: Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2"
xref: Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3"
xref: Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1"
xref: Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))"
xref: Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)"
xref: Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)"
xref: Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)"
xref: Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)"
xref: Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)"
xref: Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH"
xref: Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS"
xref: Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1"
xref: Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1"
xref: Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2"
xref: Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1"
xref: Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4"
xref: Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin"
xref: Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1"
xref: Reactome:R-HSA-9662786 "FURIN cleaves ADAM17"
xref: Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin"
xref: Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L"
xref: Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa"
xref: Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa"
xref: Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)"
xref: Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2"
xref: Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis"
xref: Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2"
xref: Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"
xref: Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid"
xref: Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"
xref: Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it"
xref: Reactome:R-HSA-9710106 "ELANE cleaves GSDMD"
xref: Reactome:R-HSA-9710263 "GZMB cleaves GSDME"
xref: Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b"
xref: Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage"
xref: Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion"
xref: Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b"
xref: Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b"
xref: Reactome:R-HSA-9829030 "Nascent F signal peptide is cleaved at ER membrane"
xref: Reactome:R-HSA-9829200 "F0 is cleaved, releasing F1, F2, F(110-136)"
xref: Reactome:R-HSA-9830805 "Nascent sG localizes to ER lumen, gets glycosylated"
xref: Reactome:R-HSA-9830882 "Nascent G signal peptide is cleaved at ER membrane"
xref: Reactome:R-HSA-9839367 "TGFBR3_mem cleavage by MMPs"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008236 ! serine-type peptidase activity

[Term]
id: GO:0004253
name: obsolete gamma-renin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "gamma-renin activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004254
name: obsolete acylaminoacyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [GOC:curators]
synonym: "acylamino-acid-releasing enzyme activity" RELATED []
synonym: "acylaminoacyl-peptidase activity" EXACT []
synonym: "N-acylpeptide hydrolase activity" RELATED []
synonym: "N-formylmethionine (fMet) aminopeptidase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004258
name: obsolete vacuolar carboxypeptidase Y
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]
comment: This term was made obsolete because it contains both component and function information.
synonym: "vacuolar carboxypeptidase Y" EXACT []
is_obsolete: true
consider: GO:0004185
consider: GO:0005773

[Term]
id: GO:0004261
name: obsolete cathepsin G activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin G activity" EXACT []
synonym: "chymotrypsin-like proteinase activity" RELATED []
synonym: "neutral proteinase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004262
name: obsolete cerevisin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "baker's yeast proteinase B" RELATED []
synonym: "brewer's yeast proteinase" NARROW []
synonym: "cerevisin activity" EXACT []
synonym: "peptidase beta" RELATED []
synonym: "proteinase yscB activity" NARROW []
synonym: "yeast proteinase B activity" NARROW []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004263
name: obsolete chymotrypsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-chymar" RELATED []
synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1]
synonym: "alpha-chymotrypsin A" RELATED []
synonym: "alpha-chymotrypsin activity" NARROW []
synonym: "avazyme" RELATED []
synonym: "chymar" RELATED []
synonym: "chymotest" RELATED []
synonym: "chymotrypsin A activity" NARROW []
synonym: "chymotrypsin activity" EXACT []
synonym: "chymotrypsin B activity" NARROW []
synonym: "chymotrypsins A and B" RELATED []
synonym: "enzeon" RELATED []
synonym: "quimar" RELATED []
synonym: "quimotrase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004274
name: obsolete dipeptidyl-peptidase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "dipeptidyl-peptidase IV activity" EXACT []
is_obsolete: true
consider: GO:0008236
consider: GO:0008239

[Term]
id: GO:0004275
name: obsolete enteropeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "enterokinase activity" RELATED []
synonym: "enteropeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004276
name: obsolete furin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "dibasic processing enzyme activity" RELATED []
synonym: "furin activity" EXACT []
synonym: "PACE" RELATED []
synonym: "paired basic amino acid cleaving enzyme" RELATED []
synonym: "paired basic amino acid converting enzyme" RELATED []
synonym: "paired basic amino acid residue cleaving enzyme activity" RELATED []
synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75]
synonym: "serine proteinase PACE" RELATED []
synonym: "SPC3" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004277
name: obsolete granzyme A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "CTLA3" RELATED []
synonym: "cytotoxic T lymphocyte serine protease" NARROW []
synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW []
synonym: "granzyme A activity" EXACT []
synonym: "HuTPS" RELATED []
synonym: "T-cell associated protease 1" RELATED []
synonym: "T-cell derived serine proteinase" NARROW []
synonym: "TSP-1" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004278
name: obsolete granzyme B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "CCP1 proteinase" NARROW []
synonym: "CCPII" RELATED []
synonym: "CTLA1" RELATED []
synonym: "cytotoxic cell proteinase-1" RELATED []
synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW []
synonym: "granzyme B activity" EXACT []
synonym: "granzyme G" RELATED []
synonym: "granzyme H" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004281
name: obsolete pancreatic elastase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "pancreatic elastase 2" RELATED []
synonym: "pancreatic elastase II activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004283
name: obsolete plasmin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "actase activity" RELATED []
synonym: "fibrinase activity" RELATED []
synonym: "fibrinolysin activity" RELATED []
synonym: "plasmin activity" EXACT []
synonym: "serum tryptase activity" RELATED []
synonym: "thrombolysin" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004284
name: obsolete acrosin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "acrosin activity" EXACT []
synonym: "acrosin amidase activity" RELATED []
synonym: "acrosomal protease activity" RELATED []
synonym: "acrosomal proteinase activity" RELATED []
synonym: "acrozonase activity" RELATED []
synonym: "alpha-acrosin" RELATED []
synonym: "beta-acrosin" RELATED []
synonym: "psi-acrosin" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004285
name: obsolete proprotein convertase 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "NEC 1 activity" NARROW []
synonym: "neuroendocrine convertase 1 activity" NARROW []
synonym: "PC1 activity" NARROW []
synonym: "prohormone convertase 3" RELATED []
synonym: "prohormone convertase I activity" NARROW []
synonym: "proprotein convertase 1 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004286
name: obsolete proprotein convertase 2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "NEC 2 activity" NARROW []
synonym: "neuroendocrine convertase 2 activity" NARROW []
synonym: "PC2 activity" NARROW []
synonym: "prohormone convertase II activity" NARROW []
synonym: "proprotein convertase 2 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004287
name: obsolete prolyl oligopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "endoprolylpeptidase activity" RELATED []
synonym: "post-proline cleaving enzyme activity" RELATED []
synonym: "post-proline endopeptidase activity" RELATED []
synonym: "proline endopeptidase activity" RELATED []
synonym: "proline-specific endopeptidase activity" RELATED []
synonym: "prolyl endopeptidase activity" RELATED []
synonym: "prolyl oligopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004289
name: obsolete subtilase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "subtilase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004290
name: obsolete kexin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "andrenorphin-Gly-generating enzyme" RELATED []
synonym: "endoproteinase Kex2p" RELATED []
synonym: "gene KEX2 dibasic proteinase" NARROW []
synonym: "Kex 2p proteinase" NARROW []
synonym: "Kex2 endopeptidase" NARROW []
synonym: "Kex2 endoprotease" NARROW []
synonym: "Kex2 endoproteinase" NARROW []
synonym: "Kex2 protease" NARROW []
synonym: "Kex2 proteinase" NARROW []
synonym: "Kex2-like endoproteinase" NARROW []
synonym: "Kex2-like precursor protein processing endoprotease" NARROW []
synonym: "kexin activity" EXACT []
synonym: "paired-basic endopeptidase activity" RELATED []
synonym: "prohormone-processing endoprotease activity" RELATED []
synonym: "prohormone-processing KEX2 proteinase" NARROW []
synonym: "prohormone-processing proteinase activity" RELATED []
synonym: "protease KEX2" RELATED []
synonym: "proteinase Kex2p" RELATED []
synonym: "proteinase yscF activity" NARROW []
synonym: "yeast cysteine proteinase F" RELATED []
synonym: "yeast KEX2 protease activity" NARROW []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004291
name: obsolete subtilisin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "alcalase 0.6L" RELATED []
synonym: "alcalase 2.5L" RELATED []
synonym: "alcalase activity" RELATED []
synonym: "ALK-enzyme" RELATED []
synonym: "bacillopeptidase A" RELATED []
synonym: "bacillopeptidase B" RELATED []
synonym: "bacillus subtilis alkaline proteinase activity" RELATED []
synonym: "bacillus subtilis alkaline proteinase bioprase activity" RELATED []
synonym: "bioprase AL 15" RELATED []
synonym: "bioprase APL 30" RELATED []
synonym: "colistinase activity" RELATED []
synonym: "esperase activity" RELATED []
synonym: "genenase I" RELATED []
synonym: "kazusase activity" RELATED []
synonym: "maxatase activity" RELATED []
synonym: "opticlean" RELATED []
synonym: "orientase 10B" RELATED []
synonym: "protease S" RELATED []
synonym: "protease VIII" RELATED []
synonym: "protease XXVII" RELATED []
synonym: "protin A 3L" RELATED []
synonym: "savinase 16.0L" RELATED []
synonym: "savinase 32.0 L EX" RELATED []
synonym: "savinase 4.0T" RELATED []
synonym: "savinase 8.0L" RELATED []
synonym: "savinase activity" RELATED []
synonym: "SP 266" RELATED []
synonym: "subtilisin activity" EXACT []
synonym: "subtilisin BL" RELATED []
synonym: "subtilisin DY" RELATED []
synonym: "subtilisin E" RELATED []
synonym: "subtilisin GX" RELATED []
synonym: "subtilisin J" RELATED []
synonym: "subtilisin S41" RELATED []
synonym: "subtilisin sendai" RELATED []
synonym: "subtilopeptidase activity" RELATED []
synonym: "superase activity" RELATED []
synonym: "thermoase" BROAD []
synonym: "thermoase PC 10" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004293
name: obsolete tissue kallikrein activity
namespace: molecular_function
alt_id: GO:0004279
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "bradykininogenase" BROAD []
synonym: "callicrein" RELATED []
synonym: "depot-padutin" RELATED []
synonym: "dilminal D" RELATED []
synonym: "glandular kallikrein activity" RELATED []
synonym: "glumorin" RELATED []
synonym: "kallidinogenase" BROAD []
synonym: "kidney kallikrein" RELATED []
synonym: "kininogenase" BROAD []
synonym: "kininogenin activity" RELATED []
synonym: "onokrein P" RELATED []
synonym: "padreatin" RELATED []
synonym: "padutin" RELATED []
synonym: "pancreatic kallikrein" RELATED []
synonym: "salivary kallikrein" RELATED []
synonym: "submandibular kallikrein" RELATED []
synonym: "submaxillary kallikrein" RELATED []
synonym: "tissue kallikrein activity" EXACT []
synonym: "urinary kallikrein" RELATED []
synonym: "urokallikrein" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004294
name: obsolete tripeptidyl-peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "tripeptidyl-peptidase II activity" EXACT []
is_obsolete: true
replaced_by: GO:0008240

[Term]
id: GO:0004295
name: obsolete trypsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-trypsin activity" NARROW []
synonym: "beta-trypsin activity" NARROW []
synonym: "cocoonase activity" RELATED []
synonym: "parenzyme" RELATED []
synonym: "parenzymol" RELATED [EC:3.4.21.4]
synonym: "pseudotrypsin" RELATED []
synonym: "sperm receptor hydrolase activity" RELATED []
synonym: "tripcellim" RELATED []
synonym: "trypsin activity" EXACT []
synonym: "tryptar" RELATED []
synonym: "trypure" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004298
name: threonine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
synonym: "26S protease" RELATED [EC:3.4.25.-]
synonym: "alkaline protease" RELATED [EC:3.4.25.-]
synonym: "ingensin" RELATED [EC:3.4.25.-]
synonym: "large multicatalytic protease" NARROW [EC:3.4.25.-]
synonym: "lens neutral proteinase" NARROW [EC:3.4.25.-]
synonym: "MCP" RELATED [EC:3.4.25.-]
synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25.-]
synonym: "multicatalytic proteinase" NARROW [EC:3.4.25.-]
synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25.-]
synonym: "prosome" RELATED [EC:3.4.25.-]
synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25.-]
synonym: "threonine endopeptidase activity" EXACT []
synonym: "tricorn protease" NARROW [EC:3.4.25.-]
synonym: "tricorn proteinase" NARROW [EC:3.4.25.-]
xref: EC:3.4.25.-
xref: Reactome:R-HSA-9818574 "TASP1 cleaves KMT2A"
xref: Reactome:R-HSA-9818577 "TASP1 cleaves KMT2B"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070003 ! threonine-type peptidase activity

[Term]
id: GO:0004299
name: obsolete proteasome endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1]
comment: This term was made obsolete because it mentions a component term in the text string.
synonym: "multicatalytic endopeptidase" RELATED []
synonym: "proteasome" RELATED []
synonym: "proteasome endopeptidase activity" EXACT []
synonym: "proteasome endopeptidase complex" RELATED []
is_obsolete: true
consider: GO:0004175
consider: GO:0008233

[Term]
id: GO:0004300
name: enoyl-CoA hydratase activity
namespace: molecular_function
alt_id: GO:0016510
def: "Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]
synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" RELATED []
synonym: "2-enoyl-CoA hydratase activity" RELATED []
synonym: "2-octenoyl coenzyme A hydrase activity" RELATED []
synonym: "3-hydroxy-fatty acyl-CoA dehydratase" EXACT []
synonym: "3-hydroxyacyl-CoA dehydratase" EXACT []
synonym: "acyl coenzyme A hydrase activity" RELATED []
synonym: "beta-hydroxyacid dehydrase activity" RELATED []
synonym: "beta-hydroxyacyl-CoA dehydrase activity" RELATED []
synonym: "enol-CoA hydratase activity" RELATED [EC:4.2.1.17]
synonym: "enoyl hydrase activity" RELATED [EC:4.2.1.17]
synonym: "short-chain enoyl-CoA hydratase activity" EXACT []
synonym: "unsaturated acyl-CoA hydratase activity" RELATED [EC:4.2.1.17]
xref: EC:4.2.1.17
xref: MetaCyc:ENOYL-COA-HYDRAT-RXN
xref: Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA"
xref: Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA"
xref: Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA"
xref: Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA"
xref: Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA"
xref: Reactome:R-HSA-77314 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA"
xref: Reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA"
xref: Reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA"
xref: Reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA"
xref: Reactome:R-HSA-9916717 "ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004301
name: epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: an epoxide + H2O = an ethanediol." [EC:3.3.2.10]
subset: goslim_chembl
synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10]
synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10]
synonym: "cytosolic epoxide hydrolase activity" RELATED [EC:3.3.2.10]
synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10]
synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10]
synonym: "sEH" RELATED [EC:3.3.2.10]
synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10]
synonym: "trans-stilbene oxide hydrolase activity" RELATED [EC:3.3.2.10]
xref: EC:3.3.2.10
xref: MetaCyc:3.3.2.10-RXN
xref: Reactome:R-HSA-2161961 "5,6-EET is hydrolysed to 5,6-DHET by EPHX2"
xref: Reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1"
xref: Reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1"
xref: Reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2"
xref: Reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4"
xref: Reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1"
xref: Reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2"
xref: Reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4"
xref: Reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1"
xref: Reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1"
xref: Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2"
xref: Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA"
xref: Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA"
xref: Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA"
xref: Reactome:R-HSA-9915968 "8,9-EET is hydrolysed to 8.9-DHET by EPHX2"
xref: Reactome:R-HSA-9915986 "11,12-EET is hydrolysed to 11,12-DHET by EPHX2"
xref: Reactome:R-HSA-9915994 "14,15-EET is hydrolysed to 14,15-DHET by EPHX2"
xref: RHEA:19037
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0004303
name: estradiol 17-beta-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]
synonym: "17-beta-estradiol dehydrogenase activity" RELATED [EC:1.1.1.62]
synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62]
synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62]
synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.62]
synonym: "17beta-estradiol dehydrogenase activity" RELATED [EC:1.1.1.62]
synonym: "17beta-HSD" RELATED [EC:1.1.1.62]
synonym: "17beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.62]
synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62]
synonym: "estradiol 17-beta-dehydrogenase activity" RELATED []
synonym: "estradiol 17beta-dehydrogenase activity" RELATED [EC:1.1.1.62]
synonym: "estradiol dehydrogenase activity" RELATED [EC:1.1.1.62]
synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" RELATED [EC:1.1.1.62]
synonym: "estrogen 17-oxidoreductase activity" RELATED [EC:1.1.1.62]
xref: EC:1.1.1.62
xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-5693390 "HSD17B11 dehydrogenates EST17b to E1"
xref: Reactome:R-HSA-5696822 "AKR1B15 reduces EST17b to E1"
xref: Reactome:R-HSA-6810594 "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)"
xref: Reactome:R-HSA-804969 "HSD17B1 hydrogenates E1 to EST17b"
xref: Reactome:R-HSA-8862137 "HSD17B2 oxidises estradiol (E2) to estrone (E1)"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004304
name: estrone sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4]
synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" RELATED [EC:2.8.2.4]
synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" RELATED [EC:2.8.2.4]
synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" RELATED [EC:2.8.2.4]
synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4]
synonym: "estrogen sulphotransferase activity" RELATED [EC:2.8.2.4]
synonym: "estrone sulphotransferase activity" EXACT []
synonym: "oestrogen sulphotransferase activity" RELATED [EC:2.8.2.4]
xref: EC:2.8.2.4
xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-176664 "estrone + PAPS => estrone 3-sulfate + PAP"
xref: RHEA:15973
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004305
name: ethanolamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine." [EC:2.7.1.82, RHEA:13069]
synonym: "ATP:ethanolamine O-phosphotransferase activity" RELATED [EC:2.7.1.82]
synonym: "ethanolamine kinase (phosphorylating)" RELATED [EC:2.7.1.82]
synonym: "ethanolamine phosphokinase activity" RELATED [EC:2.7.1.82]
xref: EC:2.7.1.82
xref: KEGG_REACTION:R01468
xref: MetaCyc:ETHANOLAMINE-KINASE-RXN
xref: Reactome:R-HSA-1483222 "ETA is phosphorylated to PETA by CHK/ETNK"
xref: RHEA:13069
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004306
name: ethanolamine-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14]
synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" RELATED [EC:2.7.7.14]
synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" RELATED [EC:2.7.7.14]
synonym: "ET" RELATED [EC:2.7.7.14]
synonym: "ethanolamine phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.14]
synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT []
synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14]
xref: EC:2.7.7.14
xref: MetaCyc:2.7.7.14-RXN
xref: Reactome:R-HSA-1483190 "PETA and CTP are condensed to CDP-ETA by PCY2"
xref: RHEA:24592
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004307
name: ethanolaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1, RHEA:32943]
synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" RELATED [EC:2.7.8.1]
synonym: "CDPethanolamine diglyceride phosphotransferase activity" RELATED [EC:2.7.8.1]
synonym: "diacylglycerol ethanolaminephosphotransferase activity" RELATED [EC:2.7.8.1]
synonym: "EPT" RELATED [EC:2.7.8.1]
synonym: "phosphorylethanolamine-glyceride transferase activity" RELATED [EC:2.7.8.1]
xref: EC:2.7.8.1
xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN
xref: Reactome:R-HSA-1482962 "CDP-ETA and DAG are converted to PE by CEPT1/EPT1"
xref: RHEA:32943
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0004308
name: exo-alpha-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18]
synonym: "acetylneuraminidase activity" RELATED [EC:3.2.1.18]
synonym: "acetylneuraminyl hydrolase activity" RELATED [EC:3.2.1.18]
synonym: "alpha-neuraminidase activity" RELATED [EC:3.2.1.18]
synonym: "N-acylneuraminate glycohydrolase activity" RELATED [EC:3.2.1.18]
synonym: "neuraminidase activity" RELATED [EC:3.2.1.18]
synonym: "sialidase activity" RELATED [EC:3.2.1.18]
xref: EC:3.2.1.18
xref: MetaCyc:3.2.1.18-RXN
xref: Reactome:R-HSA-1605723 "NEU2 cleaves GM3 to form LacCer (cytosol)"
xref: Reactome:R-HSA-1605724 "NEU1,4 hydrolyze PSAP(195-273):GM3:PE"
xref: Reactome:R-HSA-1605768 "NEU3 cleaves GM3 to form LacCer (plasma membrane)"
xref: Reactome:R-HSA-168870 "Neuraminidase enzymatic release from sialic acid"
xref: Reactome:R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates"
xref: Reactome:R-HSA-4084999 "NEU1 hydrolyses Neu5Ac from glycoconjugates"
xref: Reactome:R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates"
xref: Reactome:R-HSA-4341669 "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates"
xref: Reactome:R-HSA-9638120 "NEU4 hydrolyses Neu5Ac from glycoconjugates"
is_a: GO:0016997 ! alpha-sialidase activity

[Term]
id: GO:0004309
name: exopolyphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11]
synonym: "acid phosphoanhydride phosphohydrolase activity" RELATED [EC:3.6.1.11]
synonym: "exopolypase activity" RELATED [EC:3.6.1.11]
synonym: "Gra-Pase activity" RELATED [EC:3.6.1.11]
synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11]
synonym: "polyphosphate phosphohydrolase activity" RELATED [EC:3.6.1.11]
xref: EC:3.6.1.11
xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN
xref: RHEA:21528
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004310
name: obsolete farnesyl-diphosphate farnesyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [GOC:curators]
comment: This term was obsoleted because it represents a subreaction of squalene synthase activity ; GO:0051996.
xref: Reactome:R-HSA-191402 "Reduction of presqualene diphosphate to form squalene"
xref: Reactome:R-HSA-191405 "Two FPP molecules dimerize to form presqualene diphosphate"
is_obsolete: true
replaced_by: GO:0051996

[Term]
id: GO:0004311
name: geranylgeranyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate." [RHEA:17653]
comment: The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "farnesyltranstransferase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29]
synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" RELATED [EC:2.5.1.29]
xref: EC:2.5.1.29
xref: KEGG_REACTION:R02061
xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN
xref: RHEA:17653
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0004312
name: fatty acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" RELATED [EC:2.3.1.85]
synonym: "fatty-acid synthase activity" EXACT []
xref: EC:2.3.1.85
xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN
xref: Reactome:R-HSA-163756 "Formation of fatty acid synthase (FAS) dimer"
xref: Reactome:R-HSA-75872 "Conversion of malonyl-CoA and acetyl-CoA to palmitate"
xref: RHEA:14993
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0004313
name: [acyl-carrier-protein] S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [RHEA:41788]
synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT []
synonym: "ACAT activity" BROAD [EC:2.3.1.38]
synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" RELATED [EC:2.3.1.38]
synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" RELATED [EC:2.3.1.38]
synonym: "ACP acetyltransferase activity" RELATED [EC:2.3.1.38]
synonym: "ACP S-acetyltransferase activity" EXACT []
synonym: "ACPacetyltransferase activity" RELATED [EC:2.3.1.38]
synonym: "acyl-carrier-protein acetyltransferase activity" RELATED [EC:2.3.1.38]
synonym: "acyl-carrier-protein S-acetyltransferase activity" RELATED [EC:2.3.1.38]
synonym: "acyl-carrier-proteinacetyltransferase activity" RELATED [EC:2.3.1.38]
xref: EC:2.3.1.38
xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN
xref: RHEA:41788
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0004314
name: [acyl-carrier-protein] S-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]
synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT []
synonym: "ACP S-malonyltransferase activity" EXACT []
synonym: "acyl carrier protein malonyltransferase activity" RELATED [EC:2.3.1.39]
synonym: "acyl carrier proteinmalonyltransferase activity" RELATED [EC:2.3.1.39]
synonym: "acyl-carrier-protein S-malonyltransferase activity" RELATED [EC:2.3.1.39]
synonym: "FabD" RELATED [EC:2.3.1.39]
synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" RELATED [EC:2.3.1.39]
synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39]
synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39]
synonym: "malonyl-CoA-acyl carrier protein transacylase activity" RELATED [EC:2.3.1.39]
synonym: "malonyl-CoA:ACP transacylase activity" RELATED [EC:2.3.1.39]
synonym: "malonyl-CoA:AcpM transacylase activity" RELATED [EC:2.3.1.39]
synonym: "malonyl-CoA:acyl carrier protein transacylase activity" RELATED [EC:2.3.1.39]
synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" RELATED [EC:2.3.1.39]
synonym: "MAT" RELATED [EC:2.3.1.39]
synonym: "MCAT activity" RELATED [EC:2.3.1.39]
xref: EC:2.3.1.39
xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN
xref: Reactome:R-HSA-8933547 "MCAT transfers Mal from Mal-CoA to NDUFAB1"
is_a: GO:0016419 ! S-malonyltransferase activity

[Term]
id: GO:0004315
name: 3-oxoacyl-[acyl-carrier-protein] synthase activity
namespace: molecular_function
alt_id: GO:0033817
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [RHEA:22836]
comment: Note that this activity is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16).
synonym: "3-ketoacyl-acyl carrier protein synthase activity" RELATED [EC:2.3.1.41]
synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT []
synonym: "3-oxoacyl-ACP synthase activity" EXACT []
synonym: "3-oxoacyl-acyl carrier protein synthase I activity" NARROW [EC:2.3.1.179]
synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" RELATED [EC:2.3.1.41]
synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" RELATED [EC:2.3.1.41]
synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" RELATED [EC:2.3.1.41]
synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacyl acyl carrier protein synthase activity" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacyl synthetase activity" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacyl-ACP synthase I activity" NARROW [EC:2.3.1.41]
synonym: "beta-ketoacyl-ACP synthase II activity" NARROW [EC:2.3.1.179]
synonym: "beta-ketoacyl-ACP synthetase activity" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl carrier protein synthase activity" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" NARROW [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl-carrier-protein synthase II activity" NARROW []
synonym: "beta-ketoacylsynthase activity" RELATED [EC:2.3.1.41]
synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41]
synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41]
synonym: "ketoacyl-ACP synthase activity" EXACT []
xref: EC:2.3.1.41
xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN
xref: RHEA:22836
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0004316
name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [RHEA:17397]
synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.100]
synonym: "3-ketoacyl acyl carrier protein reductase activity" RELATED [EC:1.1.1.100]
synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT []
synonym: "3-oxoacyl-ACP reductase activity" EXACT []
synonym: "3-oxoacyl-ACPreductase activity" RELATED [EC:1.1.1.100]
synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" RELATED [EC:1.1.1.100]
synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" RELATED [EC:1.1.1.100]
synonym: "beta-ketoacyl reductase activity" RELATED [EC:1.1.1.100]
synonym: "beta-ketoacyl thioester reductase activity" RELATED [EC:1.1.1.100]
synonym: "beta-ketoacyl-ACP reductase activity" RELATED [EC:1.1.1.100]
synonym: "beta-ketoacyl-acyl carrier protein reductase activity" RELATED [EC:1.1.1.100]
synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" RELATED [EC:1.1.1.100]
synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" RELATED [EC:1.1.1.100]
xref: EC:1.1.1.100
xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN
xref: Reactome:R-HSA-8862152 "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP"
xref: RHEA:17397
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004317
name: obsolete (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [PMID:8088535]
comment: This term was obsoleted because it represents a specific substrate of (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity ; GO:0019171.
synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT []
synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT []
synonym: "(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT []
is_obsolete: true
replaced_by: GO:0019171

[Term]
id: GO:0004318
name: enoyl-[acyl-carrier-protein] reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH." [RHEA:10240]
synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" RELATED [EC:1.3.1.9]
synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" RELATED [EC:1.3.1.9]
synonym: "enoyl-ACP reductase (NADH) activity" RELATED [EC:1.3.1.9]
synonym: "enoyl-acyl-carrier-protein reductase (NADH)" RELATED [EC:1.3.1.9]
synonym: "NADH-enoyl acyl carrier protein reductase activity" RELATED [EC:1.3.1.9]
synonym: "NADH-specific enoyl-ACP reductase activity" RELATED [EC:1.3.1.9]
xref: EC:1.3.1.9
xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN
xref: RHEA:10240
is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)

[Term]
id: GO:0004319
name: obsolete enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
comment: This term was obsoleted because it captures the stereospecificity of the NADPH cofactor, which is outside the scope of GO. Consider annotating to enoyl-[acyl-carrier-protein] reductase (NADPH) activity ; GO:0141148.
synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" RELATED [EC:1.3.1.10]
synonym: "enoyl acyl-carrier-protein reductase activity" RELATED [EC:1.3.1.10]
synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT []
synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT []
synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" RELATED [EC:1.3.1.10]
synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" RELATED [EC:1.3.1.10]
synonym: "NADPH 2-enoyl Co A reductase activity" RELATED [EC:1.3.1.10]
synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.3.1.10]
is_obsolete: true
replaced_by: GO:0141148

[Term]
id: GO:0004320
name: obsolete oleoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H+ + holo-[ACP]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of fatty acyl-[ACP] hydrolase activity ; GO:0016297.
synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "oleoyl-ACP hydrolase activity" EXACT []
synonym: "oleoyl-ACP thioesterase activity" RELATED []
synonym: "oleoyl-acyl carrier protein thioesterase activity" RELATED []
synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD []
is_obsolete: true
replaced_by: GO:0016297

[Term]
id: GO:0004321
name: fatty-acyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" RELATED [EC:2.3.1.86]
synonym: "fatty acyl CoA synthase activity" EXACT []
synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86]
xref: EC:2.3.1.86
xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN
xref: RHEA:22896
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0004322
name: ferroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [RHEA:11148]
synonym: "caeruloplasmin" NARROW []
synonym: "ceruloplasmin" NARROW [EC:1.16.3.1]
synonym: "Fe(II):oxygen oxidoreductase activity" RELATED []
synonym: "ferro:O2 oxidoreductase activity" RELATED []
synonym: "ferroxidase I" RELATED []
synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" RELATED []
synonym: "HEPH" NARROW [EC:1.16.3.1]
synonym: "hephaestin" NARROW [EC:1.16.3.1]
synonym: "iron(II): oxygen oxidoreductase activity" RELATED []
synonym: "multicopper ferroxidase iron transport mediator activity" NARROW []
xref: EC:1.16.3.1
xref: MetaCyc:RXN0-1483
xref: Reactome:R-HSA-1562603 "BfrB stores iron"
xref: Reactome:R-HSA-1562604 "BfrA stores iron"
xref: Reactome:R-HSA-1562626 "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)"
xref: Reactome:R-HSA-5621402 "Defective CP does not oxidise Fe2+ to Fe3+"
xref: Reactome:R-HSA-5691107 "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)"
xref: Reactome:R-HSA-917891 "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+"
xref: Reactome:R-HSA-917933 "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+"
xref: RHEA:11148
is_a: GO:0016724 ! oxidoreductase activity, acting on metal ions, oxygen as acceptor

[Term]
id: GO:0004323
name: obsolete multicopper ferroxidase iron transport mediator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "multicopper ferroxidase iron transport mediator activity" EXACT []
is_obsolete: true
consider: GO:0004322
consider: GO:0005381

[Term]
id: GO:0004324
name: ferredoxin-NADP+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [GOC:kd, RHEA:20125]
comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'.
synonym: "ferredoxin-NADP oxidoreductase activity" RELATED [EC:1.18.1.2]
synonym: "ferredoxin-NADP reductase activity" EXACT []
synonym: "ferredoxin-NADP-oxidoreductase activity" RELATED [EC:1.18.1.2]
synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.2]
synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" RELATED [EC:1.18.1.2]
synonym: "ferredoxin-TPN reductase activity" RELATED [EC:1.18.1.2]
synonym: "ferredoxin:NADP+ oxidoreductase activity" RELATED [EC:1.18.1.2]
synonym: "NADP:ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.2]
synonym: "NADPH:ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.2]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" RELATED [EC:1.18.1.2]
synonym: "TPNH-ferredoxin reductase activity" RELATED [EC:1.18.1.2]
xref: EC:1.18.1.2
xref: MetaCyc:1.18.1.2-RXN
xref: RHEA:20125
is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity

[Term]
id: GO:0004325
name: ferrochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX." [RHEA:22584]
synonym: "ferro-protoporphyrin chelatase activity" EXACT []
synonym: "heme synthase activity" BROAD []
synonym: "heme synthetase activity" BROAD [EC:4.98.1.1]
synonym: "iron chelatase activity" BROAD [EC:4.98.1.1]
synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT []
synonym: "protoheme ferro-lyase activity" EXACT [EC:4.98.1.1]
synonym: "protoheme ferrolyase activity" EXACT []
xref: EC:4.98.1.1
xref: KEGG_REACTION:R00310
xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN
xref: Reactome:R-HSA-189465 "FECH binds Fe2+ to PRIN9 to form heme"
xref: RHEA:22584
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0004326
name: tetrahydrofolylpolyglutamate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17]
synonym: "folate polyglutamate synthetase activity" RELATED [EC:6.3.2.17]
synonym: "folylpoly(gamma-glutamate) synthase activity" RELATED [EC:6.3.2.17]
synonym: "folylpoly-gamma-glutamate synthase activity" RELATED [EC:6.3.2.17]
synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" RELATED [EC:6.3.2.17]
synonym: "folylpolyglutamate synthase activity" EXACT []
synonym: "folylpolyglutamate synthetase activity" RELATED [EC:6.3.2.17]
synonym: "folylpolyglutamyl synthetase activity" RELATED [EC:6.3.2.17]
synonym: "formyltetrahydropteroyldiglutamate synthetase activity" RELATED [EC:6.3.2.17]
synonym: "FPGS activity" RELATED [EC:6.3.2.17]
synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" RELATED [EC:6.3.2.17]
synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" RELATED [EC:6.3.2.17]
synonym: "tetrahydrofolate synthase activity" RELATED [EC:6.3.2.17]
synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" RELATED [EC:6.3.2.17]
synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.17]
synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.17]
xref: EC:6.3.2.17
xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
xref: Reactome:R-HSA-197958 "FPGS-2 transforms THF to THFPG"
xref: Reactome:R-HSA-200681 "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG"
xref: Reactome:R-HSA-200682 "Mitochondrial FPGS-1 transforms THF to THFPG"
xref: RHEA:10580
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004327
name: obsolete formaldehyde dehydrogenase (glutathione) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1]
comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries.
synonym: "formaldehyde dehydrogenase (glutathione) activity" EXACT []
is_obsolete: true
consider: GO:0051903
consider: GO:0051907

[Term]
id: GO:0004328
name: formamidase activity
namespace: molecular_function
alt_id: GO:0034566
def: "Catalysis of the reaction: formamide + H2O = formate + NH4." [RHEA:21948]
synonym: "formamide amidohydrolase activity" RELATED [EC:3.5.1.49]
synonym: "formamide hydrolase activity" EXACT []
xref: EC:3.5.1.49
xref: KEGG_REACTION:R00524
xref: MetaCyc:FORMAMIDASE-RXN
xref: RHEA:21948
xref: UM-BBD_reactionID:r0873
is_a: GO:0004040 ! amidase activity

[Term]
id: GO:0004329
name: formate-tetrahydrofolate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3]
synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw]
synonym: "10-formyltetrahydrofolate synthetase activity" RELATED [EC:6.3.4.3]
synonym: "formate:tetrahydrofolate ligase (ADP-forming)" RELATED [EC:6.3.4.3]
synonym: "formyltetrahydrofolate synthetase activity" RELATED [EC:6.3.4.3]
synonym: "tetrahydrofolate formylase activity" RELATED [EC:6.3.4.3]
synonym: "tetrahydrofolic formylase activity" RELATED [EC:6.3.4.3]
xref: EC:6.3.4.3
xref: MetaCyc:FORMATETHFLIG-RXN
xref: Reactome:R-HSA-200711 "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG"
xref: Reactome:R-HSA-5696839 "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF"
xref: Reactome:R-HSA-6801456 "MTHFD1L transforms 10-formyl-THF to HCOOH and THF"
xref: RHEA:20221
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004331
name: fructose-2,6-bisphosphate 2-phosphatase activity
namespace: molecular_function
alt_id: GO:0004330
def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46]
synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" RELATED [EC:3.1.3.46]
synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" RELATED [EC:3.1.3.46]
synonym: "fructose-2,6-bisphosphatase activity" RELATED [EC:3.1.3.46]
xref: EC:3.1.3.46
xref: MetaCyc:3.1.3.46-RXN
xref: Reactome:R-HSA-5628905 "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate"
xref: Reactome:R-HSA-70262 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate"
xref: RHEA:17289
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0004332
name: fructose-bisphosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate." [EC:4.1.2.13]
synonym: "1,6-diphosphofructose aldolase activity" RELATED [EC:4.1.2.13]
synonym: "aldolase activity" BROAD [EC:4.1.2.13]
synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.13]
synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.13]
synonym: "diphosphofructose aldolase activity" RELATED [EC:4.1.2.13]
synonym: "fructoaldolase activity" RELATED [EC:4.1.2.13]
synonym: "fructose 1,6-diphosphate aldolase activity" RELATED [EC:4.1.2.13]
synonym: "fructose 1-monophosphate aldolase activity" RELATED [EC:4.1.2.13]
synonym: "fructose 1-phosphate aldolase activity" RELATED [EC:4.1.2.13]
synonym: "fructose diphosphate aldolase activity" RELATED [EC:4.1.2.13]
synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" RELATED [EC:4.1.2.13]
synonym: "ketose 1-phosphate aldolase activity" RELATED [EC:4.1.2.13]
synonym: "phosphofructoaldolase activity" RELATED [EC:4.1.2.13]
synonym: "SMALDO" RELATED [EC:4.1.2.13]
synonym: "zymohexase activity" RELATED [EC:4.1.2.13]
xref: EC:4.1.2.13
xref: MetaCyc:F16ALDOLASE-RXN
xref: Reactome:R-HSA-71495 "Aldolase tetramers convert GA3P and DHAP to F1,6PP"
xref: Reactome:R-HSA-71496 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate"
xref: RHEA:14729
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004333
name: fumarate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate = fumarate + H2O." [EC:4.2.1.2, RHEA:12460]
synonym: "(S)-malate hydro-lyase (fumarate-forming)" RELATED [EC:4.2.1.2]
synonym: "(S)-malate hydro-lyase activity" RELATED [EC:4.2.1.2]
synonym: "fumarase activity" RELATED [EC:4.2.1.2]
synonym: "L-malate hydro-lyase activity" RELATED [EC:4.2.1.2]
xref: EC:4.2.1.2
xref: KEGG_REACTION:R01082
xref: MetaCyc:FUMHYDR-RXN
xref: Reactome:R-HSA-70982 "FH tetramer hydrates fumarate to L-malate"
xref: RHEA:12460
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004334
name: fumarylacetoacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+." [EC:3.7.1.2, RHEA:10244]
synonym: "4-fumarylacetoacetate fumarylhydrolase activity" RELATED [EC:3.7.1.2]
synonym: "beta-diketonase activity" RELATED [EC:3.7.1.2]
synonym: "fumarylacetoacetate hydrolase activity" RELATED [EC:3.7.1.2]
xref: EC:3.7.1.2
xref: KEGG_REACTION:R01364
xref: MetaCyc:FUMARYLACETOACETASE-RXN
xref: Reactome:R-HSA-71181 "FAH cleaves 4FAA"
xref: RHEA:10244
xref: UM-BBD_reactionID:r0107
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0004335
name: galactokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+." [EC:2.7.1.6, RHEA:13553]
synonym: "ATP:D-galactose 1-phosphotransferase activity" RELATED [EC:2.7.1.6]
synonym: "ATP:D-galactose-1-phosphotransferase activity" RELATED [EC:2.7.1.6]
synonym: "galactokinase (phosphorylating)" RELATED [EC:2.7.1.6]
xref: EC:2.7.1.6
xref: KEGG_REACTION:R01092
xref: MetaCyc:GALACTOKIN-RXN
xref: Reactome:R-HSA-5610026 "Defective GALK1 does not phosphorylate Gal"
xref: Reactome:R-HSA-70355 "GALK1 phosphorylates Gal to Gal1P"
xref: RHEA:13553
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004336
name: galactosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46]
synonym: "beta-galactocerebrosidase activity" RELATED [EC:3.2.1.46]
synonym: "beta-galactosylceramidase activity" RELATED [EC:3.2.1.46]
synonym: "ceramide galactosidase activity" RELATED [EC:3.2.1.46]
synonym: "cerebroside beta-galactosidase activity" RELATED [EC:3.2.1.46]
synonym: "cerebroside galactosidase activity" RELATED [EC:3.2.1.46]
synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" RELATED [EC:3.2.1.46]
synonym: "galactocerebrosidase activity" RELATED [EC:3.2.1.46]
synonym: "galactocerebroside beta-galactosidase activity" RELATED [EC:3.2.1.46]
synonym: "galactocerebroside galactosidase activity" RELATED [EC:3.2.1.46]
synonym: "galactocerebroside-beta-D-galactosidase activity" RELATED [EC:3.2.1.46]
synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46]
synonym: "galactosylceramide beta-galactosidase activity" RELATED [EC:3.2.1.46]
synonym: "galactosylcerebrosidase activity" RELATED [EC:3.2.1.46]
synonym: "galcerase activity" RELATED [EC:3.2.1.46]
synonym: "lactosylceramidase activity" RELATED [EC:3.2.1.46]
synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46]
xref: EC:3.2.1.46
xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN
xref: Reactome:R-HSA-1606564 "GALC hydrolyzes GalCer"
xref: RHEA:14297
is_a: GO:0017042 ! glycosylceramidase activity

[Term]
id: GO:0004337
name: (2E,6E)-farnesyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate." [RHEA:19361]
comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
synonym: "farnesyl diphosphate synthase activity" EXACT []
synonym: "farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.10]
synonym: "farnesyl pyrophosphate synthetase activity" EXACT []
synonym: "farnesyl-diphosphate synthase activity" EXACT []
synonym: "farnesylpyrophosphate synthetase activity" RELATED [EC:2.5.1.10]
synonym: "FPP synthetase activity" RELATED [EC:2.5.1.10]
synonym: "geranyl transferase I" RELATED [EC:2.5.1.10]
synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" RELATED [EC:2.5.1.10]
synonym: "geranyltransferase activity" RELATED [EC:2.5.1.10]
synonym: "geranyltranstransferase activity" EXACT [EC:2.5.1.10]
xref: EC:2.5.1.10
xref: KEGG_REACTION:R02003
xref: MetaCyc:FPPSYN-RXN
xref: Reactome:R-HSA-191303 "FDPS dimer transfers IPPP to GPP"
xref: Reactome:R-HSA-8870469 "RGGT geranylgeranylates RAB proteins"
xref: Reactome:R-HSA-9717830 "GGPS1 hexamer transfers IPPP to GPP"
xref: RHEA:19361
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0004338
name: glucan exo-1,3-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58]
synonym: "1,3-beta-glucan glucohydrolase activity" BROAD [EC:3.2.1.58]
synonym: "beta-1,3-glucan exo-hydrolase activity" RELATED [EC:3.2.1.58]
synonym: "exo (1->3)-beta-glucanase activity" RELATED [EC:3.2.1.58]
synonym: "exo-1,3-beta-D-glucanase activity" RELATED [EC:3.2.1.58]
synonym: "exo-1,3-beta-glucanase activity" RELATED [EC:3.2.1.58]
synonym: "exo-1,3-beta-glucosidase activity" RELATED [EC:3.2.1.58]
synonym: "exo-beta-(1->3)-D-glucanase activity" RELATED [EC:3.2.1.58]
synonym: "exo-beta-(1->3)-glucanohydrolase activity" RELATED [EC:3.2.1.58]
synonym: "exo-beta-1,3-D-glucanase activity" RELATED [EC:3.2.1.58]
synonym: "exo-beta-1,3-glucanase activity" RELATED [EC:3.2.1.58]
synonym: "glucan 1,3-beta-glucosidase activity" BROAD [GOC:mah]
xref: EC:3.2.1.58
xref: MetaCyc:3.2.1.58-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0004339
name: glucan 1,4-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3]
comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0090599', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0090599 alpha-D-glucose is released.
synonym: "1,4-alpha-D-glucan glucohydrolase activity" RELATED [EC:3.2.1.3]
synonym: "amyloglucosidase activity" RELATED [EC:3.2.1.3]
synonym: "exo-1,4-alpha-glucosidase activity" RELATED [EC:3.2.1.3]
synonym: "gamma-1,4-glucan glucohydrolase activity" RELATED [EC:3.2.1.3]
synonym: "gamma-amylase activity" RELATED [EC:3.2.1.3]
synonym: "glucoamylase activity" EXACT []
synonym: "glucose amylase activity" RELATED [EC:3.2.1.3]
synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3]
xref: EC:3.2.1.3
xref: MetaCyc:3.2.1.3-RXN
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004340
name: glucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2]
synonym: "ATP:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.2]
synonym: "glucokinase (phosphorylating)" RELATED [EC:2.7.1.2]
synonym: "glucose kinase activity" RELATED [EC:2.7.1.2]
xref: EC:2.7.1.2
xref: MetaCyc:GLUCOKIN-RXN
xref: Reactome:R-HSA-5621888 "Defective HK1 does not phosphorylate Glc to form G6P"
xref: Reactome:R-HSA-5621918 "Defective GCK does not phosphorylate Glc to form G6P"
xref: Reactome:R-HSA-70420 "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P"
xref: RHEA:17825
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0004341
name: gluconolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17]
synonym: "aldonolactonase activity" RELATED [EC:3.1.1.17]
synonym: "D-glucono-1,5-lactone lactonohydrolase activity" RELATED [EC:3.1.1.17]
synonym: "glucono-delta-lactonase activity" RELATED [EC:3.1.1.17]
synonym: "gulonolactonase activity" RELATED [EC:3.1.1.17]
synonym: "lactonase activity" BROAD [EC:3.1.1.17]
xref: EC:3.1.1.17
xref: MetaCyc:GLUCONOLACT-RXN
xref: RHEA:10440
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004342
name: glucosamine-6-phosphate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4." [EC:3.5.99.6, RHEA:12172]
synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" RELATED [EC:3.5.99.6]
synonym: "aminodeoxyglucosephosphate isomerase activity" RELATED [EC:3.5.99.6]
synonym: "GlcN6P deaminase activity" RELATED [EC:3.5.99.6]
synonym: "glucosamine phosphate deaminase activity" RELATED [EC:3.5.99.6]
synonym: "glucosamine-6-phosphate isomerase activity" RELATED [EC:3.5.99.6]
synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6]
synonym: "phosphoglucosamine isomerase activity" RELATED [EC:3.5.99.6]
synonym: "phosphoglucosaminisomerase activity" RELATED [EC:3.5.99.6]
xref: EC:3.5.99.6
xref: KEGG_REACTION:R00765
xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN
xref: Reactome:R-HSA-6799604 "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P"
xref: RHEA:12172
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004343
name: glucosamine 6-phosphate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+." [EC:2.3.1.4, RHEA:10292]
synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" RELATED [EC:2.3.1.4]
synonym: "aminodeoxyglucosephosphate acetyltransferase activity" RELATED [EC:2.3.1.4]
synonym: "D-glucosamine-6-P N-acetyltransferase activity" RELATED [EC:2.3.1.4]
synonym: "glucosamine 6-phosphate acetylase activity" RELATED [EC:2.3.1.4]
synonym: "glucosamine-6-phosphate acetylase activity" RELATED [EC:2.3.1.4]
synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT []
synonym: "N-acetylglucosamine-6-phosphate synthase activity" RELATED [EC:2.3.1.4]
synonym: "phosphoglucosamine acetylase activity" RELATED [EC:2.3.1.4]
synonym: "phosphoglucosamine N-acetylase activity" RELATED [EC:2.3.1.4]
synonym: "phosphoglucosamine transacetylase activity" RELATED [EC:2.3.1.4]
xref: EC:2.3.1.4
xref: KEGG_REACTION:R02058
xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN
xref: Reactome:R-HSA-449734 "Acetylation of glucosamine 6-phosphate to GlcNAc6P"
xref: RHEA:10292
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004344
name: glucose dehydrogenase activity
namespace: molecular_function
alt_id: GO:0008708
def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [PMID:22027299]
synonym: "glucose dehydrogenase (acceptor) activity" EXACT []
synonym: "soluble glucose dehydrogenase" EXACT [EC:1.1.99.35]
xref: EC:1.1.99.35
xref: RHEA:24540
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0004345
name: glucose-6-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]
synonym: "6-phosphoglucose dehydrogenas" RELATED []
synonym: "6-phosphoglucose dehydrogenase activity" EXACT []
synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.49]
synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49]
synonym: "G6PD activity" RELATED [EC:1.1.1.49]
synonym: "G6PDH" EXACT []
synonym: "GDH" RELATED []
synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT []
synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT []
synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT []
synonym: "Zwischenferment" RELATED [EC:1.1.1.49]
xref: EC:1.1.1.49
xref: MetaCyc:GLU6PDEHYDROG-RXN
xref: Reactome:R-HSA-70377 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+"
xref: RHEA:15841
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004346
name: glucose-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16689]
synonym: "D-glucose-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.9]
synonym: "glucose 6-phosphate phosphatase activity" RELATED [EC:3.1.3.9]
xref: EC:3.1.3.9
xref: KEGG_REACTION:R00303
xref: MetaCyc:RXN66-526
xref: Reactome:R-HSA-3262512 "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous)"
xref: Reactome:R-HSA-3266566 "G6PC2 hydrolyzes G6P to form Glc and Pi (islet)"
xref: Reactome:R-HSA-3274540 "Defective G6PC does not hydrolyze glucose 6-phosphate"
xref: Reactome:R-HSA-3282876 "Defective G6PC3 does not hydrolyze glucose 6-phosphate"
xref: Reactome:R-HSA-71825 "G6PC hydrolyzes G6P to Glc and Pi (liver)"
xref: RHEA:16689
is_a: GO:0050309 ! sugar-terminal-phosphatase activity

[Term]
id: GO:0004347
name: glucose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate." [RHEA:11816]
synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.9]
synonym: "D-glucose-6-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.9]
synonym: "glucose phosphate isomerase activity" RELATED [EC:5.3.1.9]
synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9]
synonym: "hexose phosphate isomerase activity" RELATED [EC:5.3.1.9]
synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9]
synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9]
synonym: "phosphoglucoisomerase activity" RELATED [EC:5.3.1.9]
synonym: "phosphoglucose isomerase activity" RELATED [EC:5.3.1.9]
synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9]
synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9]
synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9]
synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9]
xref: EC:5.3.1.9
xref: MetaCyc:PGLUCISOM-RXN
xref: Reactome:R-HSA-70471 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate"
xref: Reactome:R-HSA-70475 "GPI dimer isomerizes Fru(6)P to G6P"
xref: RHEA:11816
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004348
name: glucosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]
synonym: "acid beta-glucosidase activity" RELATED [EC:3.2.1.45]
synonym: "beta-D-glucocerebrosidase activity" RELATED [EC:3.2.1.45]
synonym: "beta-glucocerebrosidase activity" RELATED [EC:3.2.1.45]
synonym: "beta-glucosylceramidase activity" RELATED [EC:3.2.1.45]
synonym: "ceramide glucosidase activity" RELATED [EC:3.2.1.45]
synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" RELATED [EC:3.2.1.45]
synonym: "GlcCer-beta-glucosidase activity" RELATED [EC:3.2.1.45]
synonym: "glucocerebrosidase activity" RELATED [EC:3.2.1.45]
synonym: "glucosphingosine glucosylhydrolase activity" RELATED [EC:3.2.1.45]
synonym: "glucosylcerebrosidase activity" RELATED [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-D-glucosidase activity" RELATED [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-glucosidase activity" RELATED [EC:3.2.1.45]
synonym: "psychosine hydrolase activity" RELATED [EC:3.2.1.45]
xref: EC:3.2.1.45
xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN
xref: Reactome:R-HSA-1605591 "GBA1:SAPC hydrolyzes GlcCer"
xref: Reactome:R-HSA-1861788 "GBA2 hydrolyzes GlcCer (plasma membrane)"
xref: Reactome:R-HSA-1861789 "GBA3 hydrolyzes GlcCer (cytosol)"
xref: RHEA:13269
is_a: GO:0017042 ! glycosylceramidase activity

[Term]
id: GO:0004349
name: glutamate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+." [EC:2.7.2.11, RHEA:14877]
synonym: "ATP-L-glutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.11]
synonym: "ATP:gamma-L-glutamate phosphotransferase activity" RELATED [EC:2.7.2.11]
synonym: "ATP:L-glutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.11]
synonym: "gamma-glutamate kinase activity" RELATED [EC:2.7.2.11]
synonym: "gamma-glutamyl kinase activity" RELATED [EC:2.7.2.11]
synonym: "glutamate kinase activity" RELATED [EC:2.7.2.11]
xref: EC:2.7.2.11
xref: KEGG_REACTION:R00239
xref: MetaCyc:GLUTKIN-RXN
xref: RHEA:14877
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004350
name: glutamate-5-semialdehyde dehydrogenase activity
namespace: molecular_function
alt_id: GO:0001513
def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH." [EC:1.2.1.41, RHEA:19541]
synonym: "beta-glutamylphosphate reductase activity" RELATED [EC:1.2.1.41]
synonym: "gamma-glutamyl phosphate reductase activity" RELATED [EC:1.2.1.41]
synonym: "gamma-glutamylphosphate reductase activity" RELATED [EC:1.2.1.41]
synonym: "glutamate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.41]
synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.41]
synonym: "glutamate-phosphate reductase activity" EXACT []
synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.41]
synonym: "glutamylphosphate reductase activity" EXACT []
synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.41]
xref: EC:1.2.1.41
xref: KEGG_REACTION:R03313
xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN
xref: RHEA:19541
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004351
name: glutamate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15]
synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15]
synonym: "cysteic acid decarboxylase activity" RELATED [EC:4.1.1.15]
synonym: "gamma-glutamate decarboxylase activity" RELATED [EC:4.1.1.15]
synonym: "L-aspartate-alpha-decarboxylase activity" RELATED [EC:4.1.1.15]
synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" RELATED [EC:4.1.1.15]
synonym: "L-glutamate 1-carboxy-lyase activity" RELATED [EC:4.1.1.15]
synonym: "L-glutamate alpha-decarboxylase activity" RELATED [EC:4.1.1.15]
synonym: "L-glutamic acid decarboxylase activity" RELATED [EC:4.1.1.15]
synonym: "L-glutamic decarboxylase activity" RELATED [EC:4.1.1.15]
xref: EC:4.1.1.15
xref: MetaCyc:GLUTDECARBOX-RXN
xref: Reactome:R-HSA-888572 "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA"
xref: Reactome:R-HSA-888577 "Synthesis of GABA by GAD2"
xref: RHEA:17785
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004352
name: glutamate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "glutamate dehydrogenase (NAD)" RELATED [EC:1.4.1.2]
synonym: "glutamate oxidoreductase activity" RELATED [EC:1.4.1.2]
synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2]
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2]
synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2]
synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.2]
synonym: "NAD-dependent glutamate dehydrogenase activity" RELATED [EC:1.4.1.2]
synonym: "NAD-dependent glutamic dehydrogenase activity" RELATED [EC:1.4.1.2]
synonym: "NAD-glutamate dehydrogenase activity" RELATED [EC:1.4.1.2]
synonym: "NAD-linked glutamate dehydrogenase activity" RELATED [EC:1.4.1.2]
synonym: "NAD-linked glutamic dehydrogenase activity" RELATED [EC:1.4.1.2]
synonym: "NAD-specific glutamate dehydrogenase activity" RELATED [EC:1.4.1.2]
synonym: "NAD-specific glutamic dehydrogenase activity" RELATED [EC:1.4.1.2]
synonym: "NAD:glutamate oxidoreductase activity" RELATED [EC:1.4.1.2]
synonym: "NADH-linked glutamate dehydrogenase activity" RELATED [EC:1.4.1.2]
xref: EC:1.4.1.2
xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN
xref: RHEA:15133
is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004353
name: glutamate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3]
synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.3]
xref: EC:1.4.1.3
xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN
xref: Reactome:R-HSA-70589 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]"
xref: Reactome:R-HSA-70600 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]"
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004354
name: glutamate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" RELATED [EC:1.4.1.4]
synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4]
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4]
synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4]
synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.4]
synonym: "L-glutamic acid dehydrogenase activity" RELATED [EC:1.4.1.4]
synonym: "NAD(P)-glutamate dehydrogenase activity" RELATED [EC:1.4.1.4]
synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" RELATED [EC:1.4.1.4]
xref: EC:1.4.1.4
xref: MetaCyc:GLUTDEHYD-RXN
xref: RHEA:11612
is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004355
name: glutamate synthase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15501]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" RELATED [EC:1.4.1.13]
synonym: "glutamate synthetase (NADP) activity" RELATED [EC:1.4.1.13]
synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" RELATED [EC:1.4.1.13]
synonym: "glutamine-ketoglutaric aminotransferase activity" RELATED [EC:1.4.1.13]
synonym: "GOGAT activity" BROAD [EC:1.4.1.13]
synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13]
synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13]
synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" RELATED [EC:1.4.1.13]
synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" RELATED [EC:1.4.1.13]
synonym: "NADPH GOGAT" EXACT []
synonym: "NADPH-dependent glutamate synthase activity" RELATED [EC:1.4.1.13]
synonym: "NADPH-glutamate synthase activity" RELATED [EC:1.4.1.13]
synonym: "NADPH-linked glutamate synthase" RELATED [EC:1.4.1.13]
xref: EC:1.4.1.13
xref: KEGG_REACTION:R00114
xref: MetaCyc:GLUTAMATESYN-RXN
xref: RHEA:15501
is_a: GO:0015930 ! glutamate synthase activity

[Term]
id: GO:0004356
name: glutamine synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate." [RHEA:16169]
synonym: "glutamate-ammonia ligase activity" EXACT []
synonym: "L-glutamine synthetase activity" RELATED [EC:6.3.1.2]
xref: EC:6.3.1.2
xref: KEGG_REACTION:R00253
xref: MetaCyc:GLUTAMINESYN-RXN
xref: Reactome:R-HSA-70606 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]"
xref: RHEA:16169
is_a: GO:0016211 ! ammonia ligase activity

[Term]
id: GO:0004357
name: glutamate-cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate." [EC:6.3.2.2, RHEA:13285]
synonym: "gamma-glutamyl-L-cysteine synthetase activity" RELATED [EC:6.3.2.2]
synonym: "gamma-glutamylcysteine synthetase activity" RELATED [EC:6.3.2.2]
synonym: "gamma-glutamylcysteinyl synthetase activity" RELATED [EC:6.3.2.2]
synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" RELATED [EC:6.3.2.2]
xref: EC:6.3.2.2
xref: KEGG_REACTION:R00894
xref: MetaCyc:GLUTCYSLIG-RXN
xref: Reactome:R-HSA-174367 "GCL ligates L-Glu to L-Cys"
xref: Reactome:R-HSA-5602892 "Defective GCLC does not ligate L-Glu to L-Cys"
xref: RHEA:13285
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004358
name: glutamate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15349]
synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" RELATED [EC:2.3.1.35]
synonym: "acetylglutamate synthetase activity" RELATED [EC:2.3.1.35]
synonym: "acetylglutamate-acetylornithine transacetylase activity" RELATED [EC:2.3.1.35]
synonym: "acetylglutamic synthetase activity" RELATED [EC:2.3.1.35]
synonym: "acetylglutamic-acetylornithine transacetylase activity" RELATED [EC:2.3.1.35]
synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35]
synonym: "acetylornithine glutamate acetyltransferase activity" RELATED [EC:2.3.1.35]
synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" RELATED [EC:2.3.1.35]
synonym: "glutamate acetyltransferase activity" RELATED [EC:2.3.1.35]
synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35]
synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35]
synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35]
synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" RELATED [EC:2.3.1.35]
synonym: "ornithine acetyltransferase activity" RELATED [EC:2.3.1.35]
synonym: "ornithine transacetylase activity" RELATED [EC:2.3.1.35]
xref: EC:2.3.1.35
xref: KEGG_REACTION:R02282
xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:15349
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004359
name: glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2]
synonym: "glutaminase I" RELATED [EC:3.5.1.2]
synonym: "glutamine aminohydrolase activity" RELATED [EC:3.5.1.2]
synonym: "L-glutaminase activity" RELATED [EC:3.5.1.2]
synonym: "L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.2]
xref: EC:3.5.1.2
xref: Reactome:R-HSA-70609 "glutamine + H2O => glutamate + NH4+ [GLS]"
xref: RHEA:15889
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004360
name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13237]
synonym: "D-fructose-6-phosphate amidotransferase activity" RELATED [EC:2.6.1.16]
synonym: "GlcN6P synthase activity" RELATED [EC:2.6.1.16]
synonym: "glucosamine 6-phosphate synthase activity" RELATED [EC:2.6.1.16]
synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" RELATED [EC:2.6.1.16]
synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT []
synonym: "glucosamine-6-phosphate synthase activity" RELATED [EC:2.6.1.16]
synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16]
synonym: "hexosephosphate aminotransferase activity" RELATED [EC:2.6.1.16]
synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" RELATED [EC:2.6.1.16]
synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" RELATED [EC:2.6.1.16]
xref: EC:2.6.1.16
xref: KEGG_REACTION:R00768
xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN
xref: Reactome:R-HSA-4085027 "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P"
xref: Reactome:R-HSA-449715 "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P"
xref: RHEA:13237
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0004361
name: glutaryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]." [RHEA:13389]
synonym: "glutaryl coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.6]
xref: EC:1.3.8.6
xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-71046 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2"
xref: RHEA:13389
xref: UM-BBD_reactionID:r0198
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0004362
name: glutathione-disulfide reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [PMID:36771108, RHEA:11740]
synonym: "glutathione reductase activity" EXACT []
synonym: "glutathione S-reductase activity" RELATED [EC:1.8.1.7]
synonym: "glutathione-disulfide reductase (NADP) activity" EXACT []
synonym: "glutathione-disulfide reductase activity" EXACT []
synonym: "glutathione-disulphide reductase activity" EXACT []
synonym: "glutathione:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.7]
synonym: "GSH reductase activity" RELATED [EC:1.8.1.7]
synonym: "GSSG reductase activity" RELATED [EC:1.8.1.7]
synonym: "NADPH-glutathione reductase activity" RELATED [EC:1.8.1.7]
synonym: "NADPH-GSSG reductase activity" RELATED [EC:1.8.1.7]
synonym: "NADPH:oxidized-glutathione oxidoreductase activity" RELATED [EC:1.8.1.7]
synonym: "oxidized glutathione reduction" RELATED []
xref: EC:1.8.1.7
xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN
xref: Reactome:R-HSA-3323079 "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+"
xref: Reactome:R-HSA-71682 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+"
xref: RHEA:11740
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0004363
name: glutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate." [EC:6.3.2.3, RHEA:13557]
synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" RELATED [EC:6.3.2.3]
synonym: "glutathione synthetase activity" RELATED [EC:6.3.2.3]
synonym: "GSH synthetase activity" RELATED [EC:6.3.2.3]
xref: EC:6.3.2.3
xref: KEGG_REACTION:R00497
xref: MetaCyc:GLUTATHIONE-SYN-RXN
xref: Reactome:R-HSA-174394 "GSS:Mg2+ dimer synthesizes GSH"
xref: Reactome:R-HSA-5602901 "Defective GSS does not synthesize GSH"
xref: RHEA:13557
is_a: GO:0016881 ! acid-amino acid ligase activity
is_a: GO:1904091 ! non-ribosomal peptide synthetase activity

[Term]
id: GO:0004364
name: glutathione transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
synonym: "glutathione conjugation reaction" EXACT []
synonym: "glutathione S-alkyl transferase activity" RELATED [EC:2.5.1.18]
synonym: "glutathione S-alkyltransferase activity" RELATED [EC:2.5.1.18]
synonym: "glutathione S-aralkyltransferase activity" RELATED [EC:2.5.1.18]
synonym: "glutathione S-aryltransferase activity" RELATED [EC:2.5.1.18]
synonym: "glutathione S-transferase activity" RELATED [EC:2.5.1.18]
synonym: "RX:glutathione R-transferase activity" RELATED [EC:2.5.1.18]
synonym: "S-(hydroxyalkyl)glutathione lyase activity" RELATED [EC:2.5.1.18]
xref: EC:2.5.1.18
xref: MetaCyc:GSHTRAN-RXN
xref: Reactome:R-HSA-176054 "GST dimers conjugate GSH with cytosolic substrates"
xref: Reactome:R-HSA-176059 "GST trimers transfer GS from GSH to luminal substrates"
xref: Reactome:R-HSA-3301943 "GSTK1 dimer transfers GS from GSH to CDNB"
xref: Reactome:R-HSA-5423653 "MGST trimers transfer GS from GSH to AFXBO and AFNBO"
xref: Reactome:R-HSA-9011595 "GSTZ1 dimer dehalogenates DCA"
xref: Reactome:R-HSA-9026777 "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1"
xref: Reactome:R-HSA-9026780 "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1"
xref: Reactome:R-HSA-9026901 "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1"
xref: Reactome:R-HSA-9026911 "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1"
xref: Reactome:R-HSA-9748996 "GST dimers cleave AZA to 6MP"
xref: Reactome:R-HSA-9753280 "GSTs transfer GSH to NAPQI to form APAP-SG"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004365
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]
synonym: "3-phosphoglyceraldehyde dehydrogenase activity" RELATED [EC:1.2.1.12]
synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.12]
synonym: "dehydrogenase, glyceraldehyde phosphate" RELATED [EC:1.2.1.12]
synonym: "GAPDH activity" RELATED [EC:1.2.1.12]
synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" RELATED [EC:1.2.1.12]
synonym: "glyceraldehyde-3-P-dehydrogenase activity" RELATED [EC:1.2.1.12]
synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" RELATED [EC:1.2.1.12]
synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" RELATED [EC:1.2.1.12]
synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" RELATED [EC:1.2.1.12]
synonym: "phosphoglyceraldehyde dehydrogenase activity" RELATED [EC:1.2.1.12]
synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12]
xref: EC:1.2.1.12
xref: MetaCyc:GAPOXNPHOSPHN-RXN
xref: Reactome:R-HSA-70449 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+"
xref: Reactome:R-HSA-70482 "GAPDH tetramers reduce 1,3BPG to GA3P"
xref: RHEA:10300
is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity

[Term]
id: GO:0004366
name: glycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA." [RHEA:15325]
synonym: "3-glycerophosphate acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "alpha-glycerophosphate acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "glycerol 3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "glycerol phosphate acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "glycerol phosphate transacylase activity" RELATED [EC:2.3.1.15]
synonym: "glycerophosphate acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "glycerophosphate transacylase activity" RELATED [EC:2.3.1.15]
synonym: "sn-glycerol 3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15]
synonym: "sn-glycerol-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15]
xref: EC:2.3.1.15
xref: MetaCyc:RXN-1381
xref: Reactome:R-HSA-1482695 "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)"
xref: Reactome:R-HSA-549112 "G3P is acylated to 1-acyl LPA by AGPAT6"
xref: Reactome:R-HSA-75886 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]"
xref: RHEA:15325
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004368
name: glycerol-3-phosphate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]
synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" RELATED [EC:1.1.5.3]
synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" RELATED [EC:1.1.5.3]
synonym: "glycerol-3-phosphate CoQ reductase" RELATED [EC:1.1.5.3]
synonym: "glycerophosphate dehydrogenase activity" RELATED [EC:1.1.5.3]
synonym: "L-glycerophosphate dehydrogenase activity" RELATED [EC:1.1.5.3]
synonym: "sn-glycerol-3-phosphate dehydrogenase activity" RELATED [EC:1.1.5.3]
xref: EC:1.1.5.3
xref: MetaCyc:RXN-15745
xref: Reactome:R-HSA-188467 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)"
xref: RHEA:18977
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0004369
name: glycerol-3-phosphate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2." [EC:1.1.3.21, RHEA:18369]
synonym: "alpha-glycerophosphate oxidase activity" RELATED [EC:1.1.3.21]
synonym: "glycerol phosphate oxidase activity" RELATED [EC:1.1.3.21]
synonym: "glycerol-1-phosphate oxidase activity" RELATED [EC:1.1.3.21]
synonym: "L-alpha-glycerol-3-phosphate oxidase activity" RELATED [EC:1.1.3.21]
synonym: "L-alpha-glycerophosphate oxidase activity" RELATED [EC:1.1.3.21]
synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" RELATED [EC:1.1.3.21]
xref: EC:1.1.3.21
xref: KEGG_REACTION:R00846
xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN
xref: RHEA:18369
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0004370
name: glycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+." [EC:2.7.1.30, RHEA:21644]
synonym: "ATP:glycerol 3-phosphotransferase activity" RELATED [EC:2.7.1.30]
synonym: "ATP:glycerol-3-phosphotransferase activity" RELATED [EC:2.7.1.30]
synonym: "GK" RELATED [EC:2.7.1.30]
synonym: "glyceric kinase activity" RELATED [EC:2.7.1.30]
synonym: "glycerokinase activity" RELATED [EC:2.7.1.30]
synonym: "glycerol kinase (phosphorylating)" RELATED [EC:2.7.1.30]
xref: EC:2.7.1.30
xref: KEGG_REACTION:R00847
xref: MetaCyc:GLYCEROL-KIN-RXN
xref: Reactome:R-HSA-75887 "Conversion of Glycerol to Glycerol-3-phosphate"
xref: RHEA:21644
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004371
name: glycerone kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+." [EC:2.7.1.29, RHEA:15773]
synonym: "acetol kinase (phosphorylating)" RELATED [EC:2.7.1.29]
synonym: "acetol kinase activity" RELATED [EC:2.7.1.29]
synonym: "ATP:glycerone phosphotransferase activity" RELATED [EC:2.7.1.29]
synonym: "dihydroxyacetone kinase activity" RELATED [EC:2.7.1.29]
xref: EC:2.7.1.29
xref: KEGG_REACTION:R01011
xref: MetaCyc:GLYCERONE-KINASE-RXN
xref: RHEA:15773
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004372
name: glycine hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [RHEA:15481]
synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" RELATED [EC:2.1.2.1]
synonym: "allothreonine aldolase activity" RELATED [EC:2.1.2.1]
synonym: "L-serine hydroxymethyltransferase activity" RELATED [EC:2.1.2.1]
synonym: "serine aldolase activity" RELATED [EC:2.1.2.1]
synonym: "serine hydroxymethylase activity" RELATED [EC:2.1.2.1]
synonym: "serine hydroxymethyltransferase activity" RELATED [EC:2.1.2.1]
synonym: "serine transhydroxymethylase activity" RELATED [EC:2.1.2.1]
xref: EC:2.1.2.1
xref: MetaCyc:GLYOHMETRANS-RXN
xref: Reactome:R-HSA-5694137 "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser"
xref: RHEA:15481
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004373
name: alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H+ + UDP." [RHEA:18549]
synonym: "glycogen (starch) synthetase activity" EXACT []
synonym: "glyucogen (starch) synthase activity" EXACT []
synonym: "UDP-glucose-glycogen glucosyltransferase activity" RELATED [EC:2.4.1.11]
synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.11]
synonym: "UDP-glycogen synthase activity" RELATED [EC:2.4.1.11]
synonym: "UDPG-glycogen synthetase activity" RELATED [EC:2.4.1.11]
synonym: "UDPG-glycogen transglucosylase activity" RELATED [EC:2.4.1.11]
synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.11]
synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" RELATED [EC:2.4.1.11]
xref: EC:2.4.1.11
xref: MetaCyc:RXN-7668
xref: Reactome:R-HSA-3322001 "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1"
xref: Reactome:R-HSA-3322009 "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2"
xref: Reactome:R-HSA-3322041 "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1"
xref: Reactome:R-HSA-3828061 "Defective GYS1 does not transfer glucose to growing glycogen chains"
xref: Reactome:R-HSA-3858506 "Defective GYS2 does not transfer glucose to growing glycogen chains"
xref: RHEA:18549
is_a: GO:0033840 ! alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0004374
name: obsolete glycine cleavage system
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [GOC:curators]
comment: This term was made obsolete because it represents a process rather than a function.
synonym: "glycine cleavage system" EXACT []
synonym: "glycine synthase" BROAD []
is_obsolete: true
replaced_by: GO:0019464

[Term]
id: GO:0004375
name: glycine dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2]
synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2]
synonym: "glycine decarboxylase activity" RELATED [EC:1.4.4.2]
synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2]
synonym: "glycine-cleavage complex P-protein activity" RELATED [EC:1.4.4.2]
synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" RELATED [EC:1.4.4.2]
synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" RELATED [EC:1.4.4.2]
synonym: "P-protein" NARROW [EC:1.4.4.2]
synonym: "protein P1" NARROW [EC:1.4.4.2]
xref: EC:1.4.4.2
xref: MetaCyc:GCVP-RXN
xref: Reactome:R-HSA-5693967 "PXLP-K754-GLDC dimer decarboxylates Gly"
xref: RHEA:24304
is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor

[Term]
id: GO:0004376
name: glycolipid mannosyltransferase activity
namespace: molecular_function
alt_id: GO:0004580
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai]
synonym: "glycolipid mannosyl transferase activity" EXACT []
xref: Reactome:R-HSA-162821 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate"
xref: Reactome:R-HSA-162873 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004377
name: GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage." [EC:2.4.1.131]
synonym: "GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity" RELATED [EC:2.4.1.131]
synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.131]
synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.131]
synonym: "glycolipid 2-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.131]
synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.131]
synonym: "oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.131]
xref: EC:2.4.1.131
xref: MetaCyc:RXN-5464
xref: RHEA:29523
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0004378
name: GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage." [EC:2.4.1.132]
synonym: "GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity" EXACT systematic_synonym [EC:2.4.1.132]
synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132]
synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.132]
synonym: "glycolipid 3-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.132]
synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" RELATED [EC:2.4.1.132]
synonym: "mannosyltransferase II activity" RELATED [EC:2.4.1.132]
xref: EC:2.4.1.132
xref: MetaCyc:RXN-5462
xref: RHEA:29515
is_a: GO:0000033 ! alpha-1,3-mannosyltransferase activity
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0004379
name: glycylpeptide N-tetradecanoyltransferase activity
namespace: molecular_function
alt_id: GO:0019106
def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]
synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" RELATED [EC:2.3.1.97]
synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" RELATED [EC:2.3.1.97]
synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97]
synonym: "N-myristoyltransferase activity" EXACT []
synonym: "peptide N-myristoyltransferase activity" RELATED [EC:2.3.1.97]
synonym: "peptide N-tetradecanoyltransferase activity" RELATED [EC:2.3.1.97]
synonym: "protein N-myristoyltransferase activity" RELATED [EC:2.3.1.97]
synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" RELATED [EC:2.3.1.97]
xref: EC:2.3.1.97
xref: MetaCyc:2.3.1.97-RXN
xref: Reactome:R-HSA-184392 "N-myristoylation of GAG polyprotein by NMT2"
xref: Reactome:R-HSA-203611 "N-myristoylation of eNOS"
xref: Reactome:R-HSA-2534087 "NMT1/2 transfer MYS to GNAT1"
xref: RHEA:15521
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0019107 ! myristoyltransferase activity

[Term]
id: GO:0004380
name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40]
synonym: "A transferase activity" RELATED [EC:2.4.1.40]
synonym: "A-transferase activity" RELATED [EC:2.4.1.40]
synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "blood-group substance alpha-acetyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40]
synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" RELATED [EC:2.4.1.40]
synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40]
synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.40]
synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.40]
xref: EC:2.4.1.40
xref: MetaCyc:2.4.1.40-RXN
xref: Reactome:R-HSA-9033959 "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC"
xref: Reactome:R-HSA-9034042 "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec"
xref: RHEA:19021
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0004381
name: fucosylgalactoside 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37]
synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "B transferase activity" RELATED [EC:2.4.1.37]
synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT []
synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37]
synonym: "histo-blood substance B-dependent galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37]
synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37]
xref: EC:2.4.1.37
xref: MetaCyc:2.4.1.37-RXN
xref: Reactome:R-HSA-9033961 "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC"
xref: Reactome:R-HSA-9034053 "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen"
xref: RHEA:14349
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0004382
name: GDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [PMID:2989286, RHEA:22156]
synonym: "GDP diphosphatase activity" RELATED []
synonym: "GDP phosphohydrolase activity" RELATED [EC:3.6.1.42]
synonym: "GDPase activity" RELATED [EC:3.6.1.42]
synonym: "guanosine 5'-diphosphatase activity" RELATED [EC:3.6.1.6]
synonym: "guanosine diphosphatase activity" EXACT []
synonym: "guanosine-diphosphatase activity" EXACT []
xref: EC:3.6.1.42
xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN
xref: RHEA:22156
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0004383
name: guanylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
synonym: "GTP diphosphate-lyase (cyclizing) activity" RELATED [EC:4.6.1.2]
synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" RELATED [EC:4.6.1.2]
synonym: "guanyl cyclase activity" RELATED [EC:4.6.1.2]
synonym: "guanylyl cyclase activity" EXACT []
synonym: "receptor guanylate cyclase activity" NARROW []
xref: EC:4.6.1.2
xref: MetaCyc:GUANYLCYC-RXN
xref: Reactome:R-HSA-392152 "Soluble guanylate cyclase converts GTP to cGMP"
xref: Reactome:R-HSA-74885 "GUCYs converts GTP to cGMP"
xref: RHEA:13665
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0004384
name: obsolete membrane-associated guanylate kinase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8]
comment: This term was made obsolete because it represents a gene product and not a function.
synonym: "MAGUK" EXACT []
synonym: "membrane-associated guanylate kinase" EXACT []
is_obsolete: true
consider: GO:0004385
consider: GO:0005102
consider: GO:0007155
consider: GO:0050839

[Term]
id: GO:0004385
name: guanylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8]
synonym: "5'-GMP kinase activity" RELATED [EC:2.7.4.8]
synonym: "ATP:(d)GMP phosphotransferase activity" RELATED [EC:2.7.4.8]
synonym: "ATP:GMP phosphotransferase activity" RELATED [EC:2.7.4.8]
synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8]
synonym: "GMP kinase activity" RELATED [EC:2.7.4.8]
synonym: "guanosine monophosphate kinase activity" RELATED [EC:2.7.4.8]
synonym: "membrane-associated guanylate kinase" NARROW []
xref: EC:2.7.4.8
xref: MetaCyc:GUANYL-KIN-RXN
xref: Reactome:R-HSA-110133 "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)"
xref: Reactome:R-HSA-73788 "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)"
xref: Reactome:R-HSA-9748949 "GUK1 phosphorylates 6TGMP to 6TGDP"
xref: Reactome:R-HSA-9748963 "GUK1 phosphorylates 6TdGMP to 6TdGDP"
xref: RHEA:20780
is_a: GO:0050145 ! nucleoside monophosphate kinase activity

[Term]
id: GO:0004386
name: helicase activity
namespace: molecular_function
alt_id: GO:0008026
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]
comment: Note that most helicases catalyze processive duplex unwinding.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_pir
subset: goslim_yeast
synonym: "ATP-dependent helicase activity" EXACT []
xref: Reactome:R-HSA-169461 "MCM8 mediated fork unwinding"
xref: Reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding"
xref: Reactome:R-HSA-5686410 "BLM mediates dissolution of double Holliday junction"
xref: Reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA"
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0004392
name: heme oxygenase (decyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]." [RHEA:21764]
synonym: "haem oxidase activity" RELATED [EC:1.14.14.18]
synonym: "haem oxygenase (decyclizing) activity" EXACT []
synonym: "haem oxygenase activity" RELATED [EC:1.14.14.18]
synonym: "heme oxidase activity" RELATED [EC:1.14.14.18]
synonym: "heme oxygenase activity" RELATED [EC:1.14.14.18]
synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" RELATED [EC:1.14.14.18]
synonym: "ORP33 proteins" RELATED [EC:1.14.14.18]
xref: EC:1.14.14.18
xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN
xref: Reactome:R-HSA-189398 "HMOX1 dimer, HMOX2 cleave heme"
xref: RHEA:21764
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004394
name: heparan sulfate 2-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262]
synonym: "heparan sulfate 2-O-sulfotransferase activity" EXACT []
synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT []
synonym: "heparin 2-sulfotransferase activity" RELATED []
synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED []
xref: Reactome:R-HSA-2076508 "HS2ST1 sulfates IdoA at C2 in heparan sulfate"
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0004395
name: obsolete hexaprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity ; GO:0010420
is_obsolete: true
replaced_by: GO:0010420

[Term]
id: GO:0004396
name: hexokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]
synonym: "ATP-dependent hexokinase activity" RELATED [EC:2.7.1.1]
synonym: "ATP:D-hexose 6-phosphotransferase activity" RELATED [EC:2.7.1.1]
synonym: "glucose ATP phosphotransferase activity" RELATED [EC:2.7.1.1]
synonym: "hexokinase (phosphorylating)" RELATED [EC:2.7.1.1]
synonym: "hexokinase D" RELATED [EC:2.7.1.1]
synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type IV" RELATED [EC:2.7.1.1]
synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type IV glucokinase activity" RELATED [EC:2.7.1.1]
xref: EC:2.7.1.1
xref: MetaCyc:HEXOKINASE-RXN
xref: RHEA:22740
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004397
name: histidine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3]
synonym: "histidase activity" RELATED [GOC:hjd]
synonym: "histidinase activity" RELATED [GOC:hjd]
synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd]
synonym: "L-histidine ammonia-lyase (urocanate-forming)" RELATED [EC:4.3.1.3]
synonym: "L-histidine ammonia-lyase activity" RELATED [EC:4.3.1.3]
xref: EC:4.3.1.3
xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN
xref: Reactome:R-HSA-70899 "histidine => urocanate + NH4+"
xref: RHEA:21232
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0004398
name: histidine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22]
synonym: "L-histidine carboxy-lyase (histamine-forming)" RELATED [EC:4.1.1.22]
synonym: "L-histidine carboxy-lyase activity" RELATED [EC:4.1.1.22]
synonym: "L-histidine decarboxylase activity" RELATED [EC:4.1.1.22]
xref: EC:4.1.1.22
xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN
xref: Reactome:R-HSA-977301 "Histidine is decarboxylated to histamine"
xref: RHEA:20840
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004399
name: histidinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-histidinol + 2 NAD+ = 3 H+ + L-histidine + 2 NADH." [RHEA:20641]
xref: EC:1.1.1.23
xref: MetaCyc:RXN-8001
xref: RHEA:20641
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004400
name: histidinol-phosphate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9]
synonym: "glutamic-imidazoleacetol phosphate transaminase activity" RELATED [EC:2.6.1.9]
synonym: "histidine:imidazoleacetol phosphate transaminase activity" RELATED [EC:2.6.1.9]
synonym: "histidinol phosphate aminotransferase activity" RELATED [EC:2.6.1.9]
synonym: "histidinol-phosphate aminotransferase activity" EXACT []
synonym: "IAP transaminase activity" RELATED [EC:2.6.1.9]
synonym: "imidazole acetol-phosphate transaminase activity" RELATED [EC:2.6.1.9]
synonym: "imidazoleacetol phosphate transaminase activity" RELATED [EC:2.6.1.9]
synonym: "imidazolylacetolphosphate aminotransferase activity" RELATED [EC:2.6.1.9]
synonym: "imidazolylacetolphosphate transaminase activity" RELATED [EC:2.6.1.9]
synonym: "L-histidinol phosphate aminotransferase activity" RELATED [EC:2.6.1.9]
synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.9]
xref: EC:2.6.1.9
xref: MetaCyc:HISTAMINOTRANS-RXN
xref: RHEA:23744
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004401
name: histidinol-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate." [EC:3.1.3.15, RHEA:14465]
synonym: "histidinol phosphate phosphatase activity" RELATED [EC:3.1.3.15]
synonym: "histidinolphosphatase activity" RELATED [EC:3.1.3.15]
synonym: "histidinolphosphate phosphatase activity" RELATED [EC:3.1.3.15]
synonym: "HPpase activity" RELATED [EC:3.1.3.15]
synonym: "L-histidinol phosphate phosphatase activity" RELATED [EC:3.1.3.15]
synonym: "L-histidinol-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.15]
xref: EC:3.1.3.15
xref: KEGG_REACTION:R03013
xref: MetaCyc:HISTIDPHOS-RXN
xref: RHEA:14465
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004402
name: histone acetyltransferase activity
namespace: molecular_function
alt_id: GO:0004403
alt_id: GO:0004404
alt_id: GO:0004405
alt_id: GO:0004406
alt_id: GO:0043166
alt_id: GO:0046971
def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48, PMID:19056256]
synonym: "acetyl-CoA:histone acetyltransferase activity" RELATED [EC:2.3.1.48]
synonym: "H2A/H2B histone acetyltransferase activity" NARROW []
synonym: "H3/H4 histone acetyltransferase activity" NARROW []
synonym: "H4/H2 histone acetyltransferase activity" NARROW []
synonym: "H4/H2A acetyltransferase activity" NARROW []
synonym: "histone acetokinase activity" RELATED [EC:2.3.1.48]
synonym: "histone acetylase activity" EXACT []
synonym: "histone lysine acetyltransferase activity" EXACT []
synonym: "histone transacetylase activity" RELATED [EC:2.3.1.48]
synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48]
xref: EC:2.3.1.48
xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-3301237 "KAT2 complexes acetylate histone H3"
xref: Reactome:R-HSA-3301345 "Elongator complex acetylates replicative histone H3, H4"
xref: Reactome:R-HSA-3318413 "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3"
xref: Reactome:R-HSA-3318415 "ATF2 acetylates histone H2B, H4"
xref: Reactome:R-HSA-3318486 "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3"
xref: Reactome:R-HSA-3321805 "NSL acetylates histone H4"
xref: Reactome:R-HSA-3321883 "MSL acetylates histone H4"
xref: Reactome:R-HSA-3321975 "NuA4 complex acetylates histone H2A, HIST1H4"
xref: Reactome:R-HSA-3451147 "KAT5 HAT complex acetylates TCF4 gene at histone H4"
xref: Reactome:R-HSA-3662318 "Type B histone acetlytransferase complex acetylates histone H4"
xref: Reactome:R-HSA-3662335 "EP300 acetylates histone H2A, H2B, H3, H4"
xref: Reactome:R-HSA-3697008 "CREBBP acetylates histone H2B, H3, H4"
xref: Reactome:R-HSA-3697920 "CLOCK acetylates lysine-10 of histone H3, H4"
xref: Reactome:R-HSA-5144542 "CLOCK acetylates lysine-15 of histone H3, H4"
xref: Reactome:R-HSA-5250938 "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9"
xref: RHEA:21992
is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0004407
name: histone deacetylase activity
namespace: molecular_function
def: "Removal of an acetyl group from a lysine residue in a histone." [PMID:24691964, PMID:9893272, RHEA:58196]
comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
synonym: "histone deacetylase activity (NAD-independent)" EXACT []
xref: Reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin"
xref: Reactome:R-HSA-2545253 "Deacetylation of cohesin"
xref: Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones"
xref: Reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone"
xref: Reactome:R-HSA-3782637 "HDAC8 deacetylates histones"
xref: Reactome:R-HSA-3782655 "HDAC10 deacetylates histone"
xref: Reactome:R-HSA-427514 "eNoSC deacetylates histone H3"
xref: Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3"
xref: Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53"
is_a: GO:0033558 ! protein lysine deacetylase activity

[Term]
id: GO:0004408
name: holocytochrome-c synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17]
synonym: "cytochrome c heme-lyase activity" RELATED [EC:4.4.1.17]
synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17]
synonym: "holocytochrome c synthetase activity" RELATED [EC:4.4.1.17]
synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" RELATED [EC:4.4.1.17]
synonym: "holocytochrome-c apocytochrome-c-lyase activity" RELATED [EC:4.4.1.17]
xref: EC:4.4.1.17
xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN
xref: Reactome:R-HSA-9866217 "HCCS inserts heme into cytochrome c"
xref: RHEA:22648
is_a: GO:0016846 ! carbon-sulfur lyase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004409
name: homoaconitate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O." [EC:4.2.1.36, RHEA:15485]
synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36]
synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" RELATED [EC:4.2.1.36]
synonym: "cis-homoaconitase activity" RELATED [EC:4.2.1.36]
synonym: "HACN activity" RELATED [EC:4.2.1.36]
synonym: "homoaconitase activity" RELATED [EC:4.2.1.36]
synonym: "Lys4" RELATED [EC:4.2.1.36]
synonym: "LysF" RELATED [EC:4.2.1.36]
xref: EC:4.2.1.36
xref: KEGG_REACTION:R04371
xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN
xref: RHEA:15485
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004410
name: homocitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate." [RHEA:12929]
synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" RELATED [EC:2.3.3.14]
synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" RELATED [EC:2.3.3.14]
synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" RELATED [EC:2.3.3.14]
synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" RELATED [EC:2.3.3.14]
synonym: "homocitrate synthetase activity" RELATED [EC:2.3.3.14]
xref: EC:2.3.3.14
xref: KEGG_REACTION:R00271
xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN
xref: RHEA:12929
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004411
name: homogentisate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+." [EC:1.13.11.5, RHEA:15449]
synonym: "homogentisate dioxygenase activity" RELATED [EC:1.13.11.5]
synonym: "homogentisate oxidase activity" RELATED [EC:1.13.11.5]
synonym: "homogentisate oxygenase activity" RELATED [EC:1.13.11.5]
synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.5]
synonym: "homogentisic acid oxidase activity" RELATED [EC:1.13.11.5]
synonym: "homogentisic acid oxygenase activity" RELATED [EC:1.13.11.5]
synonym: "homogentisic oxygenase activity" RELATED [EC:1.13.11.5]
synonym: "homogentisicase activity" RELATED [EC:1.13.11.5]
xref: EC:1.13.11.5
xref: KEGG_REACTION:R02519
xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN
xref: Reactome:R-HSA-71164 "HGD dioxygenates homogentisate"
xref: RHEA:15449
xref: UM-BBD_reactionID:r0105
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004412
name: homoserine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3]
xref: EC:1.1.1.3
xref: MetaCyc:HOMOSERDEHYDROG-RXN
xref: RHEA:15761
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004413
name: homoserine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+." [EC:2.7.1.39, RHEA:13985]
synonym: "ATP:L-homoserine O-phosphotransferase activity" RELATED [EC:2.7.1.39]
synonym: "homoserine kinase (phosphorylating)" RELATED [EC:2.7.1.39]
synonym: "HSK" RELATED [EC:2.7.1.39]
xref: EC:2.7.1.39
xref: KEGG_REACTION:R01771
xref: MetaCyc:HOMOSERKIN-RXN
xref: RHEA:13985
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004414
name: homoserine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA." [EC:2.3.1.31, RHEA:13701]
synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" RELATED [EC:2.3.1.31]
synonym: "homoserine acetyltransferase activity" RELATED [EC:2.3.1.31]
synonym: "homoserine O-trans-acetylase activity" RELATED [EC:2.3.1.31]
synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31]
synonym: "homoserine-O-transacetylase activity" RELATED [EC:2.3.1.31]
synonym: "L-homoserine O-acetyltransferase activity" RELATED [EC:2.3.1.31]
xref: EC:2.3.1.31
xref: KEGG_REACTION:R01776
xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN
xref: RHEA:13701
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004415
name: hyalurononglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35]
synonym: "chondroitinase activity" BROAD [EC:3.2.1.35]
synonym: "chondroitinase I activity" RELATED [EC:3.2.1.35]
synonym: "hyaluronate 4-glycanohydrolase activity" RELATED [EC:3.2.1.35]
synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35]
synonym: "hyaluronoglucosaminidase activity" EXACT []
synonym: "hyaluronoglucosidase activity" RELATED [EC:3.2.1.35]
xref: EC:3.2.1.35
xref: MetaCyc:3.2.1.35-RXN
xref: Reactome:R-HSA-1793209 "HYAL1 hydrolyses Chondroitin chains"
xref: Reactome:R-HSA-2160874 "HYAL1 hydrolyses (HA)50"
xref: Reactome:R-HSA-2160892 "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments"
xref: Reactome:R-HSA-2318585 "Defective HYAL1 does not hydrolyse Chondroitin chains"
xref: Reactome:R-HSA-5693356 "CEMIP hydrolyses HA"
xref: Reactome:R-HSA-9036077 "Defective HYAL1 does not hydrolyse (HA)50"
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004416
name: hydroxyacylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6]
synonym: "acetoacetylglutathione hydrolase activity" RELATED [EC:3.1.2.6]
synonym: "glyoxalase II activity" RELATED [EC:3.1.2.6]
synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" RELATED [EC:3.1.2.6]
synonym: "S-2-hydroxylacylglutathione hydrolase activity" RELATED [EC:3.1.2.6]
xref: EC:3.1.2.6
xref: MetaCyc:GLYOXII-RXN
xref: Reactome:R-HSA-6783221 "HAGH hydrolyses (R)-S-LGSH to GSH and LACT"
xref: RHEA:25245
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0004417
name: hydroxyethylthiazole kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+." [EC:2.7.1.50, RHEA:24212]
synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" RELATED [EC:2.7.1.50]
synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" RELATED [EC:2.7.1.50]
synonym: "hydroxyethylthiazole kinase (phosphorylating)" RELATED [EC:2.7.1.50]
xref: EC:2.7.1.50
xref: KEGG_REACTION:R04448
xref: MetaCyc:THIAZOLSYN3-RXN
xref: RHEA:24212
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004418
name: hydroxymethylbilane synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4." [EC:2.5.1.61, RHEA:13185]
synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" RELATED [EC:2.5.1.61]
synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" RELATED [EC:2.5.1.61]
synonym: "HMB-synthase activity" RELATED [EC:2.5.1.61]
synonym: "porphobilinogen ammonia-lyase (polymerizing)" RELATED [EC:2.5.1.61]
synonym: "porphobilinogen deaminase activity" RELATED [EC:2.5.1.61]
synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" RELATED [EC:2.5.1.61]
synonym: "pre-uroporphyrinogen synthase activity" RELATED [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen synthase activity" RELATED [EC:2.5.1.61]
synonym: "uroporphyrinogen synthetase activity" RELATED [EC:2.5.1.61]
xref: EC:2.5.1.61
xref: KEGG_REACTION:R00084
xref: MetaCyc:OHMETHYLBILANESYN-RXN
xref: Reactome:R-HSA-189406 "4 PBGs bind to form HMB"
xref: RHEA:13185
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004419
name: hydroxymethylglutaryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24404]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.4]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" RELATED [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" RELATED [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" RELATED [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" RELATED [EC:4.1.3.4]
synonym: "HMG-CoA lyase activity" RELATED [EC:4.1.3.4]
synonym: "hydroxymethylglutaryl coenzyme A lyase activity" RELATED [EC:4.1.3.4]
synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4]
xref: EC:4.1.3.4
xref: KEGG_REACTION:R01360
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
xref: Reactome:R-HSA-6788597 "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA"
xref: Reactome:R-HSA-74180 "HMG CoA => acetoacetic acid + acetyl CoA"
xref: RHEA:24404
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004420
name: hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: molecular_function
alt_id: GO:0042282
def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH." [PMID:29224355, RHEA:15989]
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34]
synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34]
synonym: "hydroxymethylglutaryl-CoA reductase activity" RELATED []
xref: EC:1.1.1.34
xref: KEGG_REACTION:R02082
xref: MetaCyc:1.1.1.34-RXN
xref: Reactome:R-HSA-191352 "HMGCR dimer reduces bHMG-CoA to MVA"
xref: RHEA:15989
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004421
name: hydroxymethylglutaryl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+." [RHEA:10188]
synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" RELATED [EC:2.3.3.10]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" RELATED [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" RELATED [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" RELATED [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" RELATED [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" RELATED [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" RELATED [EC:2.3.3.10]
synonym: "acetoacetyl coenzyme A transacetase activity" RELATED [EC:2.3.3.10]
synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.10]
synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" RELATED [EC:2.3.3.10]
synonym: "HMG-CoA synthase activity" RELATED [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme A synthase activity" RELATED [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" RELATED [EC:2.3.3.10]
xref: EC:2.3.3.10
xref: KEGG_REACTION:R01978
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
xref: Reactome:R-HSA-191323 "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA"
xref: Reactome:R-HSA-73918 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH"
xref: RHEA:10188
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004422
name: hypoxanthine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [RHEA:17973]
synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "HGPRTase activity" RELATED [EC:2.4.2.8]
synonym: "HPRT" RELATED [EC:2.4.2.8]
synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "IMP diphosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "IMP pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "IMP-GMP pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "inosinate pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "inosine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "inosinic acid pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "inosinic pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8]
xref: KEGG_REACTION:R01132
xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN
xref: RHEA:17973
is_a: GO:0106130 ! purine phosphoribosyltransferase activity

[Term]
id: GO:0004423
name: iduronate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13]
synonym: "2-sulfo-L-iduronate 2-sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13]
synonym: "iduronate sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "iduronate sulfate sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "iduronate-2-sulfate sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "iduronate-2-sulphatase activity" EXACT []
synonym: "iduronide-2-sulfate sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "idurono-2-sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "L-iduronate 2-sulfate sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" RELATED [EC:3.1.6.13]
synonym: "L-idurono sulfate sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "L-iduronosulfatase activity" RELATED [EC:3.1.6.13]
synonym: "sulfo-L-iduronate sulfatase activity" RELATED [EC:3.1.6.13]
synonym: "sulfoiduronate sulfohydrolase activity" RELATED [EC:3.1.6.13]
xref: EC:3.1.6.13
xref: MetaCyc:3.1.6.13-RXN
xref: Reactome:R-HSA-1678650 "IDS hydrolyses Heparan sulfate chain(5)"
xref: Reactome:R-HSA-1793182 "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)"
xref: Reactome:R-HSA-2262743 "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)"
xref: Reactome:R-HSA-9036046 "Defective IDS does not hydrolyse Heparan sulfate chain(5)"
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004424
name: imidazoleglycerol-phosphate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O." [EC:4.2.1.19, RHEA:11040]
synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19]
synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" RELATED [EC:4.2.1.19]
synonym: "IGP dehydratase activity" RELATED [EC:4.2.1.19]
synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT []
xref: EC:4.2.1.19
xref: KEGG_REACTION:R03457
xref: MetaCyc:IMIDPHOSDEHYD-RXN
xref: RHEA:11040
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004425
name: indole-3-glycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48]
synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" RELATED [EC:4.1.1.48]
synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48]
synonym: "indole-3-glycerophosphate synthase activity" RELATED [EC:4.1.1.48]
synonym: "indoleglycerol phosphate synthase activity" RELATED [EC:4.1.1.48]
synonym: "indoleglycerol phosphate synthetase activity" RELATED [EC:4.1.1.48]
xref: EC:4.1.1.48
xref: MetaCyc:IGPSYN-RXN
xref: RHEA:23476
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004427
name: inorganic diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate." [EC:3.6.1.1, RHEA:24576]
synonym: "diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.1]
synonym: "inorganic diphosphatase activity" EXACT []
synonym: "inorganic pyrophosphatase activity" RELATED [EC:3.6.1.1]
synonym: "pyrophosphate phosphohydrolase activity" RELATED [EC:3.6.1.1]
xref: EC:3.6.1.1
xref: KEGG_REACTION:R00004
xref: MetaCyc:INORGPYROPHOSPHAT-RXN
xref: Reactome:R-HSA-449937 "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]"
xref: Reactome:R-HSA-6788912 "LHPP:Mg2+ dimer hydrolyses PPi"
xref: Reactome:R-HSA-71732 "PPA1 hydrolyzes pyrophosphate to orthophosphate"
xref: RHEA:24576
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004428
name: obsolete inositol or phosphatidylinositol kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
synonym: "inositol or phosphatidylinositol kinase activity" EXACT []
synonym: "inositol/phosphatidylinositol kinase activity" EXACT []
is_obsolete: true
consider: GO:0019140
consider: GO:0052742

[Term]
id: GO:0004430
name: 1-phosphatidylinositol 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+." [EC:2.7.1.67, RHEA:19877]
synonym: "phosphatidylinositol 4-kinase activity" EXACT [EC:2.7.1.67]
synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67]
synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67]
synonym: "PI kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI4-kinase activity" EXACT [EC:2.7.1.67]
synonym: "PI4K" EXACT [EC:2.7.1.67]
synonym: "PI4K-alpha activity" EXACT [EC:2.7.1.67]
synonym: "PtdIns-4-kinase activity" EXACT [EC:2.7.1.67]
synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67]
xref: EC:2.7.1.67
xref: KEGG_REACTION:R03361
xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN
xref: Reactome:R-HSA-1675780 "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane"
xref: Reactome:R-HSA-1675813 "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane"
xref: Reactome:R-HSA-1675883 "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane"
xref: Reactome:R-HSA-1675974 "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane"
xref: Reactome:R-HSA-1676185 "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane"
xref: RHEA:19877
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0004432
name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA
namespace: molecular_function
def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418]
comment: This term was made obsolete because it is not a valid molecular function.
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" EXACT []
is_obsolete: true
consider: GO:0016308

[Term]
id: GO:0004433
name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB
namespace: molecular_function
def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418]
comment: This term was made obsolete because it is not a valid molecular function.
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" EXACT []
is_obsolete: true
consider: GO:0016308

[Term]
id: GO:0004435
name: phosphatidylinositol phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]
synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" RELATED [EC:3.1.4.11]
synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" RELATED [EC:3.1.4.11]
synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT []
synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11]
synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED []
synonym: "phosphoinositidase C activity" RELATED [EC:3.1.4.11]
synonym: "phosphoinositide phospholipase C activity" RELATED [EC:3.1.4.11]
synonym: "PI-PLC activity" RELATED [EC:3.1.4.11]
synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11]
xref: EC:3.1.4.11
xref: KEGG_REACTION:R03435
xref: MetaCyc:3.1.4.11-RXN
xref: Reactome:R-HSA-111879 "PIP2 hydrolysis"
xref: Reactome:R-HSA-167686 "Active PLCG1 hydrolyses PIP2"
xref: Reactome:R-HSA-1855177 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane"
xref: Reactome:R-HSA-1855214 "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane"
xref: Reactome:R-HSA-1855221 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane"
xref: Reactome:R-HSA-202407 "PLC-gamma1 hydrolyses PIP2"
xref: Reactome:R-HSA-2730847 "Hydrolysis of PIP2 by PLCG"
xref: Reactome:R-HSA-5607735 "p-Y753,Y759-PLCG2 hydrolyses PIP2"
xref: Reactome:R-HSA-622382 "PIP2 hydrolysis"
xref: Reactome:R-HSA-9032478 "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate"
xref: Reactome:R-HSA-9717205 "GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG"
xref: RHEA:33179
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0004436
name: phosphatidylinositol diacylglycerol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13]
synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" RELATED [EC:4.6.1.13]
synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" RELATED [EC:4.6.1.13]
synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" RELATED [EC:4.6.1.13]
synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT []
synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13]
xref: EC:4.6.1.13
xref: MetaCyc:3.1.4.10-RXN
xref: RHEA:17093
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0004437
name: obsolete inositol or phosphatidylinositol phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
synonym: "inositol or phosphatidylinositol phosphatase activity" EXACT []
synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT []
is_obsolete: true
consider: GO:0034593
consider: GO:0034594
consider: GO:0052744
consider: GO:0052745

[Term]
id: GO:0004438
name: phosphatidylinositol-3-phosphate phosphatase activity
namespace: molecular_function
alt_id: GO:0016315
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]
comment: Note that this function includes EC:3.1.3.65.
synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.64]
synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.64]
synonym: "inositol 1,3-bisphosphate phosphatase activity" RELATED [EC:3.1.3.64]
synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" RELATED [EC:3.1.3.64]
synonym: "inositol-polyphosphate 3-phosphatase activity" RELATED [EC:3.1.3.64]
synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.64]
synonym: "phosphatidylinositol-3-phosphatase activity" EXACT []
xref: EC:3.1.3.64
xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN
xref: Reactome:R-HSA-1675795 "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane"
xref: Reactome:R-HSA-1675994 "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane"
xref: Reactome:R-HSA-1676114 "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane"
xref: Reactome:R-HSA-1676141 "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane"
xref: Reactome:R-HSA-6809325 "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane"
xref: Reactome:R-HSA-6809720 "PI3P is dephosphorylated to PI by MTM1:MTMR12"
xref: Reactome:R-HSA-6809777 "PI3P is dephosphorylated to PI by MTMR2:SBF1"
xref: Reactome:R-HSA-6809975 "PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane"
xref: RHEA:12316
is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity

[Term]
id: GO:0004439
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
alt_id: GO:0001668
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [RHEA:22764]
synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" RELATED [EC:3.1.3.36]
synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36]
synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36]
synonym: "PI(4,5)P2 5-phosphatase activity" EXACT [GOC:mah, PMID:15249580]
synonym: "PtdIns(4,5)P(2) 5-phosphatase activity" RELATED [EC:3.1.3.36, GOC:mah]
synonym: "PtdIns(4,5)P2 5-phosphatase activity" RELATED [EC:3.1.3.36, GOC:mah]
synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36]
synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36]
xref: EC:3.1.3.36
xref: KEGG_REACTION:R04404
xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN
xref: Reactome:R-HSA-1675824 "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane"
xref: Reactome:R-HSA-1676177 "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane"
xref: Reactome:R-HSA-8868648 "SYNJ hydrolyze PI(4,5)P2 to PI(4)P"
xref: RHEA:22764
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity
is_a: GO:0106019 ! phosphatidylinositol-4,5-bisphosphate phosphatase activity

[Term]
id: GO:0004441
name: inositol-1,4-bisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb]
synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.57]
synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57]
synonym: "inositol-polyphosphate 1-phosphatase activity" RELATED [EC:3.1.3.57]
xref: EC:3.1.3.57
xref: MetaCyc:3.1.3.57-RXN
xref: Reactome:R-HSA-1855208 "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol"
xref: RHEA:15553
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity

[Term]
id: GO:0004442
name: obsolete inositol-1,4,-bisphosphate 3-phosphatase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators]
synonym: "inositol-1,4,-bisphosphate 3-phosphatase" EXACT []
is_obsolete: true
consider: GO:0004438

[Term]
id: GO:0004443
name: obsolete inositol-1,4,-bisphosphate 4-phosphatase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators]
synonym: "inositol-1,4,-bisphosphate 4-phosphatase" EXACT []
is_obsolete: true
consider: GO:0016316

[Term]
id: GO:0004444
name: obsolete inositol-1,4,5-trisphosphate 1-phosphatase
namespace: molecular_function
def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb]
comment: This term was made obsolete because the existence of this function has not been established.
synonym: "inositol-1,4,5-trisphosphate 1-phosphatase" EXACT []
is_obsolete: true
consider: GO:0046030

[Term]
id: GO:0004445
name: inositol-polyphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]
comment: Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'.
synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.56]
synonym: "5PTase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56]
synonym: "inositol polyphosphate-5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inositol triphosphate 5-phosphomonoesterase activity" RELATED []
synonym: "inositol trisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.56]
synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW []
synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56]
synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED []
synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW []
xref: EC:3.1.3.56
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0004446
name: inositol-hexakisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62]
synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.62]
synonym: "inositol tetrakisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.62]
synonym: "MIPP activity" BROAD [EC:3.1.3.62]
synonym: "multiple inositol-polyphosphate phosphatase activity" BROAD [EC:3.1.3.62]
xref: EC:3.1.3.62
xref: MetaCyc:RXN-7920
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0004447
name: iodide peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O." [RHEA:23336]
synonym: "iodinase activity" RELATED [EC:1.11.1.8]
synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8]
synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8]
synonym: "TPO activity" RELATED [EC:1.11.1.8]
xref: EC:1.11.1.8
xref: MetaCyc:IODIDE-PEROXIDASE-RXN
xref: RHEA:23336
is_a: GO:0140905 ! haloperoxidase activity

[Term]
id: GO:0004448
name: isocitrate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H." [GOC:curators]
subset: gocheck_do_not_annotate
synonym: "IDH activity" RELATED []
synonym: "IDP activity" RELATED []
synonym: "isocitrate dehydrogenase activity" EXACT []
synonym: "isocitric acid dehydrogenase activity" EXACT []
synonym: "isocitric dehydrogenase activity" EXACT []
synonym: "oxalosuccinate carboxylase activity" EXACT []
synonym: "oxalosuccinate decarboxylase activity" EXACT []
synonym: "oxalosuccinic decarboxylase activity" EXACT []
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004449
name: isocitrate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH." [RHEA:23632]
synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41]
synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41]
synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
xref: EC:1.1.1.41
xref: Reactome:R-HSA-70967 "IDH3 complex decarboxylates isocitrate"
xref: RHEA:23632
is_a: GO:0004448 ! isocitrate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004450
name: isocitrate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH." [RHEA:19629]
synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42]
synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42]
synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP(+)-ICDH activity" RELATED [EC:1.1.1.42]
synonym: "NADP(+)-IDH activity" RELATED [EC:1.1.1.42]
synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
xref: EC:1.1.1.42
xref: MetaCyc:ISOCITDEH-RXN
xref: Reactome:R-HSA-389540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+"
xref: Reactome:R-HSA-389550 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+"
xref: Reactome:R-HSA-450984 "IDH2 dimer decarboxylates isocitrate"
xref: RHEA:19629
is_a: GO:0004448 ! isocitrate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004451
name: isocitrate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate = glyoxylate + succinate." [EC:4.1.3.1, RHEA:13245]
synonym: "ICL activity" RELATED [EC:4.1.3.1]
synonym: "isocitrase activity" RELATED [EC:4.1.3.1]
synonym: "isocitratase activity" RELATED [EC:4.1.3.1]
synonym: "isocitrate glyoxylate-lyase (succinate-forming)" RELATED [EC:4.1.3.1]
synonym: "isocitrate glyoxylate-lyase activity" RELATED [EC:4.1.3.1]
synonym: "isocitritase activity" RELATED [EC:4.1.3.1]
synonym: "threo-DS-isocitrate glyoxylate-lyase activity" RELATED [EC:4.1.3.1]
xref: EC:4.1.3.1
xref: KEGG_REACTION:R00479
xref: MetaCyc:ISOCIT-CLEAV-RXN
xref: RHEA:13245
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004452
name: isopentenyl-diphosphate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [RHEA:23284]
synonym: "IPP isomerase activity" RELATED [EC:5.3.3.2]
synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT []
synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" RELATED [EC:5.3.3.2]
synonym: "isopentenylpyrophosphate delta-isomerase activity" RELATED [EC:5.3.3.2]
synonym: "isopentenylpyrophosphate isomerase activity" RELATED [EC:5.3.3.2]
synonym: "methylbutenylpyrophosphate isomerase activity" RELATED [EC:5.3.3.2]
xref: EC:5.3.3.2
xref: KEGG_REACTION:R01123
xref: MetaCyc:IPPISOM-RXN
xref: Reactome:R-HSA-191382 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate"
xref: RHEA:23284
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004453
name: juvenile-hormone esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [PMID:11267890, RHEA:16393]
subset: goslim_chembl
synonym: "JH esterase activity" RELATED [EC:3.1.1.59]
synonym: "JH-esterase activity" RELATED [EC:3.1.1.59]
synonym: "juvenile hormone analog esterase activity" RELATED [EC:3.1.1.59]
synonym: "juvenile hormone carboxyesterase activity" RELATED [EC:3.1.1.59]
synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" RELATED [EC:3.1.1.59]
xref: EC:3.1.1.59
xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN
xref: RHEA:16393
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004454
name: ketohexokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3]
synonym: "ATP:D-fructose 1-phosphotransferase activity" RELATED [EC:2.7.1.3]
synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3]
synonym: "ketohexokinase (phosphorylating)" RELATED [EC:2.7.1.3]
xref: EC:2.7.1.3
xref: MetaCyc:KETOHEXOKINASE-RXN
xref: Reactome:R-HSA-5656459 "Defective KHK does not phosphorylate beta-D-fructose"
xref: Reactome:R-HSA-70333 "KHK dimer phosphorylates Fru to Fru 1-P"
xref: RHEA:18145
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004455
name: ketol-acid reductoisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86]
synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" RELATED [EC:1.1.1.86]
synonym: "2-hydroxy-3-keto acid reductoisomerase activity" RELATED [EC:1.1.1.86]
synonym: "acetohydroxy acid isomeroreductase activity" RELATED [EC:1.1.1.86]
synonym: "acetohydroxy acid reductoisomerase activity" RELATED [EC:1.1.1.86]
synonym: "acetolactate reductoisomerase activity" RELATED [EC:1.1.1.86]
synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" RELATED [EC:1.1.1.86]
synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" RELATED [EC:1.1.1.86]
synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" RELATED [EC:1.1.1.86]
synonym: "isomeroreductase activity" RELATED [EC:1.1.1.86]
synonym: "ketol acid reductoisomerase activity" RELATED [EC:1.1.1.86]
synonym: "reductoisomerase activity" RELATED [EC:1.1.1.86]
xref: EC:1.1.1.86
xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN
xref: RHEA:22068
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004456
name: phosphogluconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O." [EC:4.2.1.12, RHEA:17277]
synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" RELATED [EC:4.2.1.12]
synonym: "6-phospho-D-gluconate hydro-lyase activity" RELATED [EC:4.2.1.12]
synonym: "6-phosphogluconate dehydrase activity" RELATED [EC:4.2.1.12]
synonym: "6-phosphogluconate dehydratase activity" RELATED [EC:4.2.1.12]
synonym: "6-phosphogluconic dehydrase activity" RELATED [EC:4.2.1.12]
synonym: "gluconate 6-phosphate dehydratase activity" RELATED [EC:4.2.1.12]
synonym: "gluconate-6-phosphate dehydratase activity" RELATED [EC:4.2.1.12]
xref: EC:4.2.1.12
xref: KEGG_REACTION:R02036
xref: MetaCyc:PGLUCONDEHYDRAT-RXN
xref: RHEA:17277
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004457
name: lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." [GOC:ai, GOC:bf]
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0004458
name: D-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate." [RHEA:13521]
synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT []
synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" RELATED []
synonym: "D-(-)-lactic cytochrome c reductase activity" RELATED [EC:1.1.2.4]
synonym: "D-lactate (cytochrome) dehydrogenase activity" RELATED [EC:1.1.2.4]
synonym: "D-lactate ferricytochrome c oxidoreductase activity" RELATED [EC:1.1.2.4]
synonym: "D-lactate-cytochrome c reductase activity" RELATED []
synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4]
xref: EC:1.1.2.4
xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
xref: RHEA:13521
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0004459
name: L-lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23444]
synonym: "L-lactic acid dehydrogenase activity" RELATED [EC:1.1.1.27]
synonym: "L-lactic dehydrogenase activity" RELATED [EC:1.1.1.27]
xref: EC:1.1.1.27
xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-6807826 "LDHAL6B reduces PYR to LACT"
xref: Reactome:R-HSA-70510 "LDH tetramer oxidises LACT to PYR"
xref: Reactome:R-HSA-71849 "LDH tetramer reduces PYR to LACT"
xref: RHEA:23444
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004460
name: L-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate." [RHEA:19909]
synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" RELATED [EC:1.1.2.3]
synonym: "cytochrome b2" RELATED []
synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3]
synonym: "dehydrogenase, lactate (cytochrome)" RELATED [EC:1.1.2.3]
synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3]
synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" RELATED [EC:1.1.2.3]
synonym: "L-lactate cytochrome c oxidoreductase activity" RELATED [EC:1.1.2.3]
synonym: "L-lactate cytochrome c reductase activity" RELATED [EC:1.1.2.3]
synonym: "L-lactate ferricytochrome c oxidoreductase activity" RELATED [EC:1.1.2.3]
synonym: "lactate dehydrogenase (cytochrome)" RELATED [EC:1.1.2.3]
synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3]
synonym: "lactic cytochrome c reductase activity" RELATED [EC:1.1.2.3]
xref: EC:1.1.2.3
xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
xref: RHEA:19909
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0004461
name: lactose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22]
synonym: "lactose synthetase activity" RELATED [EC:2.4.1.22]
synonym: "UDP-galactose-glucose galactosyltransferase activity" RELATED [EC:2.4.1.22]
synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" RELATED [EC:2.4.1.22]
synonym: "UDPgalactose-glucose galactosyltransferase activity" RELATED [EC:2.4.1.22]
synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" RELATED [EC:2.4.1.22]
synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" RELATED [EC:2.4.1.22]
xref: EC:2.4.1.22
xref: MetaCyc:LACTOSE-SYNTHASE-RXN
xref: Reactome:R-HSA-5653878 "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac"
xref: RHEA:12404
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0004462
name: lactoylglutathione lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19069]
synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" RELATED [EC:4.4.1.5]
synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" RELATED [EC:4.4.1.5]
synonym: "aldoketomutase activity" RELATED [EC:4.4.1.5]
synonym: "glyoxalase I activity" RELATED [EC:4.4.1.5]
synonym: "glyoxylase I" RELATED [EC:4.4.1.5]
synonym: "ketone-aldehyde mutase activity" RELATED [EC:4.4.1.5]
synonym: "methylglyoxalase activity" RELATED [EC:4.4.1.5]
xref: EC:4.4.1.5
xref: KEGG_REACTION:R02530
xref: MetaCyc:GLYOXI-RXN
xref: Reactome:R-HSA-5694071 "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH"
xref: RHEA:19069
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004463
name: leukotriene-A4 hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22324]
synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" RELATED [EC:3.3.2.6]
synonym: "leukotriene A(4) hydrolase activity" RELATED [EC:3.3.2.6]
synonym: "leukotriene A4 hydrolase activity" RELATED [EC:3.3.2.6]
synonym: "LTA-4 hydrolase activity" RELATED [EC:3.3.2.6]
synonym: "LTA4 hydrolase activity" RELATED [EC:3.3.2.6]
synonym: "LTA4H" RELATED [EC:3.3.2.6]
xref: EC:3.3.2.6
xref: KEGG_REACTION:R03057
xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN
xref: Reactome:R-HSA-266072 "LTA4 is hydolysed to LTB4 by LTA4H"
xref: RHEA:22324
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0004464
name: leukotriene-C4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)." [EC:4.4.1.20, RHEA:17617]
comment: Note that this function was EC:2.5.1.37.
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" RELATED [EC:4.4.1.20]
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" RELATED [EC:4.4.1.20]
synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" RELATED [EC:4.4.1.20]
synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" RELATED [EC:4.4.1.20]
synonym: "leukotriene C(4) synthetase activity" RELATED [EC:4.4.1.20]
synonym: "leukotriene C4 synthetase activity" RELATED [EC:4.4.1.20]
synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" RELATED [EC:4.4.1.20]
synonym: "LTC(4) synthase activity" RELATED [EC:4.4.1.20]
synonym: "LTC(4) synthetase activity" RELATED [EC:4.4.1.20]
synonym: "LTC4 synthase activity" RELATED [EC:4.4.1.20]
synonym: "LTC4 synthetase activity" RELATED [EC:4.4.1.20]
xref: EC:4.4.1.20
xref: KEGG_REACTION:R03059
xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN
xref: Reactome:R-HSA-266050 "LTA4 is converted to LTC4 by LTC4S"
xref: RHEA:17617
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004465
name: lipoprotein lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. May also hydrolyze diacylglycerol and phospholipids present in lipoproteins." [EC:3.1.1.34, GOC:bf]
synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34]
synonym: "diacylglycerol hydrolase activity" RELATED [EC:3.1.1.34]
synonym: "diacylglycerol lipase activity" RELATED [EC:3.1.1.34]
synonym: "diglyceride lipase activity" RELATED [EC:3.1.1.34]
synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34]
synonym: "postheparin esterase activity" RELATED [EC:3.1.1.34]
synonym: "postheparin lipase activity" RELATED [EC:3.1.1.34]
synonym: "triacylglycero-protein acylhydrolase activity" RELATED [EC:3.1.1.34]
xref: EC:3.1.1.34
xref: Reactome:R-HSA-1482811 "DAG is hydrolyzed to 2-MAG by PNPLA2/3"
xref: Reactome:R-HSA-174757 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols"
xref: Reactome:R-HSA-2395768 "LPL hydrolyses TGs from mature CMs"
xref: Reactome:R-HSA-6789310 "LIPs hydrolyse TG to DAG and RCOOH"
xref: Reactome:R-HSA-8979996 "LIPs hydrolyze TG to DAG and LCFA"
xref: Reactome:R-HSA-8980228 "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA"
is_a: GO:0004806 ! triacylglycerol lipase activity

[Term]
id: GO:0004466
name: long-chain fatty acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [RHEA:17721]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain acyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.8]
synonym: "long-chain-acyl-CoA dehydrogenase activity" EXACT []
synonym: "palmitoyl-CoA dehydrogenase activity" NARROW []
synonym: "palmitoyl-coenzyme A dehydrogenase activity" NARROW []
xref: EC:1.3.8.8
xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN
xref: RHEA:17721
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0004467
name: long-chain fatty acid-CoA ligase activity
namespace: molecular_function
alt_id: GO:0003996
def: "Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [RHEA:15421]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "acyl-activating enzyme activity" BROAD []
synonym: "acyl-CoA ligase activity" RELATED []
synonym: "acyl-CoA synthetase activity" RELATED [EC:6.2.1.3]
synonym: "fatty acid thiokinase (long-chain) activity" RELATED []
synonym: "LCFA synthetase activity" RELATED []
synonym: "lignoceroyl-CoA synthase activity" RELATED []
synonym: "long chain fatty acyl-CoA synthetase activity" RELATED []
synonym: "long-chain acyl CoA synthetase activity" RELATED []
synonym: "long-chain acyl-CoA synthetase activity" EXACT []
synonym: "long-chain acyl-coenzyme A synthetase activity" RELATED []
synonym: "long-chain fatty acid activation" RELATED []
synonym: "long-chain fatty acyl coenzyme A synthetase activity" RELATED []
synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT []
synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT []
synonym: "pristanoyl-CoA synthetase" NARROW []
synonym: "stearoyl-CoA synthetase" NARROW []
synonym: "thiokinase" RELATED []
xref: EC:6.2.1.3
xref: MetaCyc:RXN-7904
xref: Reactome:R-HSA-159425 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)"
xref: Reactome:R-HSA-192137 "THCA is conjugated with Coenzyme A (SLC27A5 BACS)"
xref: Reactome:R-HSA-193401 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
xref: Reactome:R-HSA-193407 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)"
xref: Reactome:R-HSA-193424 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
xref: Reactome:R-HSA-193711 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)"
xref: Reactome:R-HSA-193727 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
xref: Reactome:R-HSA-193743 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
xref: Reactome:R-HSA-193766 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)"
xref: Reactome:R-HSA-201035 "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA"
xref: Reactome:R-HSA-2046085 "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA"
xref: Reactome:R-HSA-2046098 "Activation of linoleic acid to linoleoyl-CoA"
xref: Reactome:R-HSA-548843 "ACSL3,4 ligate CoA to AA to form AA-CoA"
xref: Reactome:R-HSA-5696004 "ACSF2 ligates CoA-SH to MCFA"
xref: Reactome:R-HSA-9734535 "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA"
xref: RHEA:15421
is_a: GO:0120515 ! fatty acid-CoA ligase activity

[Term]
id: GO:0004468
name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32]
synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" RELATED [EC:2.3.1.32]
synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" RELATED [EC:2.3.1.32]
synonym: "LAT activity" RELATED [EC:2.3.1.32]
synonym: "lysine acetyltransferase activity" EXACT []
synonym: "lysine N(6)-acetyltransferase activity" RELATED [EC:2.3.1.32]
synonym: "lysine N6-acetyltransferase activity" RELATED [EC:2.3.1.32]
xref: EC:2.3.1.32
xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-5618328 "ATAT acetylates microtubules"
xref: Reactome:R-HSA-5693001 "NAT8,8B acetylate BACE1"
xref: RHEA:14417
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004470
name: malic enzyme activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732]
synonym: "pyruvic-malic carboxylase activity" RELATED [EC:1.1.1.39]
is_a: GO:0016615 ! malate dehydrogenase activity

[Term]
id: GO:0004471
name: malate dehydrogenase (decarboxylating) (NAD+) activity
namespace: molecular_function
alt_id: GO:0004472
alt_id: GO:0016619
def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH." [RHEA:12653]
comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
synonym: "'malic' enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39]
synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.39]
synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" RELATED [EC:1.1.1.38]
synonym: "malate dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.39]
synonym: "malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT []
synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38]
synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38, EC:1.1.1.39]
synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39]
xref: EC:1.1.1.39
xref: KEGG_REACTION:R00214
xref: MetaCyc:1.1.1.39-RXN
xref: Reactome:R-HSA-9012268 "ME2 tetramer decarboxylates MAL to PYR"
xref: RHEA:12653
is_a: GO:0004470 ! malic enzyme activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004473
name: malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH." [RHEA:18253]
comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
synonym: "'malic' enzyme" RELATED [EC:1.1.1.40]
synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" RELATED [EC:1.1.1.40]
synonym: "L-malate:NADP oxidoreductase activity" RELATED [EC:1.1.1.40]
synonym: "malate dehydrogenase (decarboxylating, NADP)" RELATED [EC:1.1.1.40]
synonym: "malate dehydrogenase (NADP, decarboxylating)" RELATED [EC:1.1.1.40]
synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40]
synonym: "NADP-malic enzyme activity" RELATED [EC:1.1.1.40]
synonym: "NADP-specific malate dehydrogenase activity" RELATED [EC:1.1.1.40]
synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40]
xref: EC:1.1.1.40
xref: KEGG_REACTION:R00216
xref: MetaCyc:MALIC-NADP-RXN
xref: Reactome:R-HSA-9012036 "ME1 tetramer decarboxylates MAL to PYR"
xref: Reactome:R-HSA-9012349 "ME3 tetramer decarboxylates MAL to PYR"
xref: RHEA:18253
is_a: GO:0004470 ! malic enzyme activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004474
name: malate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+." [RHEA:18181]
synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.9]
synonym: "glyoxylate transacetase activity" RELATED [EC:2.3.3.9]
synonym: "glyoxylate transacetylase activity" RELATED [EC:2.3.3.9]
synonym: "glyoxylic transacetase activity" RELATED [EC:2.3.3.9]
synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" RELATED [EC:2.3.3.9]
synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9]
synonym: "malate synthetase activity" RELATED [EC:2.3.3.9]
synonym: "malic synthetase activity" RELATED [EC:2.3.3.9]
synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9]
xref: EC:2.3.3.9
xref: KEGG_REACTION:R00472
xref: MetaCyc:MALSYN-RXN
xref: RHEA:18181
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004475
name: mannose-1-phosphate guanylyltransferase (GTP) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [RHEA:15229]
synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13]
synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.13]
synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.13]
synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13]
synonym: "guanosine diphosphomannose pyrophosphorylase activity" RELATED [EC:2.7.7.13]
synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.13]
synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" RELATED [EC:2.7.7.13]
synonym: "mannose-1-phosphate guanylyltransferase activity" BROAD []
synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13]
xref: EC:2.7.7.13
xref: KEGG_REACTION:R00885
xref: MetaCyc:2.7.7.13-RXN
xref: Reactome:R-HSA-446221 "GMPPB converts Mannose-1-phosphate to GDP-Mannose"
xref: RHEA:15229
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0004476
name: mannose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [RHEA:12356]
synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.8]
synonym: "D-mannose-6-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.8]
synonym: "mannose phosphate isomerase activity" RELATED [EC:5.3.1.8]
synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8]
synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8]
synonym: "phosphomannoisomerase activity" RELATED [EC:5.3.1.8]
synonym: "phosphomannose isomerase activity" RELATED [EC:5.3.1.8]
xref: EC:5.3.1.8
xref: MetaCyc:MANNPISOM-RXN
xref: Reactome:R-HSA-3781832 "Defective MPI does not  isomerize Fru6P to Man6P"
xref: Reactome:R-HSA-532549 "MPI isomerises Fru6P to Man6P"
xref: RHEA:12356
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004477
name: methenyltetrahydrofolate cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9]
synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw]
synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" RELATED [EC:3.5.4.9]
synonym: "citrovorum factor cyclodehydrase activity" RELATED [EC:3.5.4.9]
synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" RELATED [EC:3.5.4.9]
xref: EC:3.5.4.9
xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN
xref: Reactome:R-HSA-200661 "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG"
xref: Reactome:R-HSA-200740 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate"
xref: Reactome:R-HSA-6801328 "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF"
xref: RHEA:23700
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0004478
name: methionine adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6]
synonym: "adenosylmethionine synthetase activity" RELATED [EC:2.5.1.6]
synonym: "AdoMet synthetase activity" RELATED [EC:2.5.1.6]
synonym: "ATP-methionine adenosyltransferase activity" RELATED [EC:2.5.1.6]
synonym: "ATP:L-methionine S-adenosyltransferase activity" RELATED [EC:2.5.1.6]
synonym: "methionine S-adenosyltransferase activity" RELATED [EC:2.5.1.6]
synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6]
synonym: "S-adenosyl-L-methionine synthetase activity" RELATED [EC:2.5.1.6]
synonym: "S-adenosylmethionine synthase activity" RELATED [EC:2.5.1.6]
synonym: "S-adenosylmethionine synthetase activity" RELATED [EC:2.5.1.6]
xref: EC:2.5.1.6
xref: MetaCyc:S-ADENMETSYN-RXN
xref: Reactome:R-HSA-174391 "MAT1A multimers transfer Ado from ATP to L-Met"
xref: Reactome:R-HSA-5603087 "Defective MAT1A does not transfer Ado from ATP to L-Met"
xref: Reactome:R-HSA-5603114 "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met"
xref: RHEA:21080
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004479
name: methionyl-tRNA formyltransferase activity
namespace: molecular_function
alt_id: GO:0001718
alt_id: GO:0070128
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9]
synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" RELATED [EC:2.1.2.9]
synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators]
synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators]
synonym: "formylmethionyl-transfer ribonucleic synthetase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl ribonucleic formyltransferase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl-transfer ribonucleic transformylase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl-transfer RNA transformylase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl-tRNA Met formyltransferase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl-tRNA transformylase activity" RELATED [EC:2.1.2.9]
synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators]
synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" RELATED [EC:2.1.2.9]
synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators]
synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" RELATED [EC:2.1.2.9]
xref: EC:2.1.2.9
xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN
xref: Reactome:R-HSA-5389841 "MTFMT formylates methionyl-tRNA"
xref: RHEA:24380
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0004481
name: methylene-fatty-acyl-phospholipid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16]
synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16]
synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" RELATED [EC:2.1.1.16]
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16]
xref: EC:2.1.1.16
xref: MetaCyc:2.1.1.16-RXN
xref: RHEA:17549
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004482
name: mRNA 5'-cap (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56]
synonym: "guanine-7-methyltransferase activity" RELATED [EC:2.1.1.56]
synonym: "messenger ribonucleate guanine 7-methyltransferase activity" RELATED [EC:2.1.1.56]
synonym: "messenger RNA guanine 7-methyltransferase activity" RELATED [EC:2.1.1.56]
synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" RELATED [EC:2.1.1.56]
synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" RELATED [EC:2.1.1.56]
xref: EC:2.1.1.56
xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase"
xref: Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs"
xref: Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)"
xref: Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)"
xref: Reactome:R-HSA-9694476 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs"
xref: Reactome:R-HSA-9694492 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)"
xref: Reactome:R-HSA-9694737 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)"
xref: Reactome:R-HSA-9830848 "L protein acts as a cap N7 methyltransferase to modify RSV mRNAs"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0004483
name: mRNA (nucleoside-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57]
synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" RELATED [EC:2.1.1.57]
synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" RELATED [EC:2.1.1.57]
synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" RELATED [EC:2.1.1.57]
synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" RELATED [EC:2.1.1.57]
xref: EC:2.1.1.57
xref: MetaCyc:2.1.1.57-RXN
xref: Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)"
xref: Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)"
xref: Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs"
xref: Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs"
xref: Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)"
xref: Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)"
xref: Reactome:R-HSA-9834003 "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs"
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0004484
name: mRNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]
synonym: "GTP--RNA guanylyltransferase activity" RELATED [EC:2.7.7.50]
synonym: "GTP:mRNA guanylyltransferase activity" EXACT []
synonym: "messenger RNA guanylyltransferase activity" RELATED [EC:2.7.7.50]
synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50]
synonym: "protein lambda2" RELATED [EC:2.7.7.50]
xref: EC:2.7.7.50
xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN
xref: Reactome:R-HSA-77081 "Formation of the CE:GMP intermediate complex"
xref: Reactome:R-HSA-77083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA"
xref: Reactome:R-HSA-9815529 "nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs"
xref: RHEA:54592
is_a: GO:0008192 ! RNA guanylyltransferase activity

[Term]
id: GO:0004485
name: methylcrotonoyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate." [EC:6.4.1.4, RHEA:13589]
synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.4]
synonym: "beta-methylcrotonyl CoA carboxylase activity" RELATED [EC:6.4.1.4]
synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.4]
synonym: "beta-methylcrotonyl-CoA carboxylase activity" RELATED [EC:6.4.1.4]
synonym: "MCCC activity" EXACT [GOC:bf]
synonym: "methylcrotonyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.4]
synonym: "methylcrotonyl-CoA carboxylase activity" RELATED [EC:6.4.1.4]
xref: EC:6.4.1.4
xref: KEGG_REACTION:R04138
xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN
xref: Reactome:R-HSA-508308 "beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + CO2 (MCCA)"
xref: Reactome:R-HSA-70773 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]"
xref: Reactome:R-HSA-9909466 "MCCC mutants don't synthesize beta-methylglutaconyl-CoA"
xref: RHEA:13589
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0004486
name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [GOC:vw]
synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw]
synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" RELATED []
xref: Reactome:R-HSA-200644 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+"
xref: Reactome:R-HSA-200718 "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004487
name: methylenetetrahydrofolate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH." [RHEA:22892]
synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.5]
synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" RELATED [EC:1.5.1.15]
xref: EC:1.5.1.15
xref: KEGG_REACTION:R01218
xref: MetaCyc:1.5.1.15-RXN
xref: Reactome:R-HSA-6801462 "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF"
xref: RHEA:22892
is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004488
name: methylenetetrahydrofolate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22812]
synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" RELATED [EC:1.5.1.5]
synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.5]
xref: EC:1.5.1.5
xref: KEGG_REACTION:R01220
xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN
xref: RHEA:22812
is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004489
name: methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: molecular_function
alt_id: GO:0008702
def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20, PMID:26872964]
synonym: "5,10-CH(2)-H(4)folate reductase activity" RELATED [EC:1.5.1.20]
synonym: "5,10-CH2-H4folate reductase activity" RELATED [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT []
synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT []
synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" RELATED [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" RELATED [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" RELATED [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" RELATED [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" RELATED [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" RELATED [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.20]
synonym: "MetF" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase (NADPH2)" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20]
synonym: "MTHFR activity" BROAD [EC:1.5.1.20]
synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "N5,10-methylenetetrahydrofolate reductase activity" RELATED [EC:1.5.1.20]
synonym: "N5,N10-methylenetetrahydrofolate reductase activity" RELATED [EC:1.5.1.20]
xref: EC:1.5.1.20
xref: KEGG_REACTION:R01224
xref: KEGG_REACTION:R07168
xref: MetaCyc:1.5.1.20-RXN
xref: Reactome:R-HSA-200676 "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004490
name: methylglutaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O." [EC:4.2.1.18, RHEA:21536]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" RELATED [EC:4.2.1.18]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" RELATED [EC:4.2.1.18]
synonym: "3-methylglutaconyl CoA hydratase activity" RELATED [EC:4.2.1.18]
synonym: "methylglutaconase activity" RELATED [EC:4.2.1.18]
synonym: "methylglutaconyl coenzyme A hydratase activity" RELATED [EC:4.2.1.18]
xref: EC:4.2.1.18
xref: KEGG_REACTION:R02085
xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN
xref: Reactome:R-HSA-70785 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA"
xref: Reactome:R-HSA-9914271 "AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA"
xref: RHEA:21536
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004491
name: methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product." [EC:1.2.1.27, PMID:2768248]
synonym: "methylmalonate-semialdehyde dehydrogenase (acylating) activity" RELATED []
synonym: "MMSA dehydrogenase activity" RELATED [EC:1.2.1.27]
synonym: "MSDH activity" RELATED [EC:1.2.1.27]
xref: EC:1.2.1.27
xref: MetaCyc:1.2.1.27-RXN
xref: Reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+"
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004492
name: methyl/ethyl malonyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H+ = CO2 + propanoyl-CoA or (2S)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2." [PMID:22016388]
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" NARROW []
synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" NARROW []
synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" NARROW []
synonym: "ethylmalonyl-CoA decarboxylase activity" NARROW []
synonym: "methylmalonyl-coenzyme A decarboxylase activity" NARROW []
xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004493
name: methylmalonyl-CoA epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20553]
synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" RELATED [EC:5.1.99.1]
synonym: "DL-methylmalonyl-CoA racemase activity" RELATED [EC:5.1.99.1]
synonym: "methylmalonyl coenzyme A racemase activity" RELATED [EC:5.1.99.1]
synonym: "methylmalonyl-CoA 2-epimerase activity" RELATED [EC:5.1.99.1]
synonym: "methylmalonyl-CoA racemase activity" RELATED [EC:5.1.99.1]
xref: EC:5.1.99.1
xref: KEGG_REACTION:R02765
xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN
xref: Reactome:R-HSA-71020 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA"
xref: RHEA:20553
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0004494
name: methylmalonyl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." [EC:5.4.99.2, RHEA:22888]
synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" RELATED [EC:5.4.99.2]
synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" RELATED [EC:5.4.99.2]
synonym: "(S)-methylmalonyl-CoA mutase activity" RELATED [EC:5.4.99.2]
synonym: "methylmalonyl coenzyme A carbonylmutase activity" RELATED [EC:5.4.99.2]
synonym: "methylmalonyl coenzyme A mutase activity" RELATED [EC:5.4.99.2]
synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" RELATED [EC:5.4.99.2]
xref: EC:5.4.99.2
xref: KEGG_REACTION:R00833
xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN
xref: Reactome:R-HSA-3322971 "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA"
xref: Reactome:R-HSA-71010 "MUT isomerises L-MM-CoA to SUCC-CoA"
xref: RHEA:22888
xref: UM-BBD_reactionID:r0922
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0004495
name: obsolete mevaldate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [GOC:curators]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0004496
name: mevalonate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+." [EC:2.7.1.36, RHEA:17065]
synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" RELATED [EC:2.7.1.36]
synonym: "ATP:mevalonate 5-phosphotransferase activity" RELATED [EC:2.7.1.36]
synonym: "mevalonate 5-phosphotransferase activity" RELATED [EC:2.7.1.36]
synonym: "mevalonate kinase (phosphorylating)" RELATED [EC:2.7.1.36]
synonym: "mevalonate phosphokinase activity" RELATED [EC:2.7.1.36]
synonym: "mevalonic acid kinase activity" RELATED [EC:2.7.1.36]
synonym: "mevalonic kinase activity" RELATED [EC:2.7.1.36]
synonym: "MVA kinase activity" RELATED [EC:2.7.1.36]
xref: EC:2.7.1.36
xref: KEGG_REACTION:R02245
xref: MetaCyc:MEVALONATE-KINASE-RXN
xref: Reactome:R-HSA-191380 "Mevalonate is phosphorylated to mevalonate-5-phosphate"
xref: RHEA:17065
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004497
name: monooxygenase activity
namespace: molecular_function
def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]
subset: goslim_pir
synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk]
xref: Reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde"
xref: Reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO"
xref: Reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone"
xref: Reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA"
xref: Reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation"
xref: Reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2"
xref: Reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA"
xref: Reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole"
xref: Reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide"
xref: Reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST"
xref: Reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA"
xref: Reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM"
xref: Reactome:R-HSA-211968 "CYP2W1 oxidises INDOL"
xref: Reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation"
xref: Reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6"
xref: Reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation"
xref: Reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole"
xref: Reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO"
xref: Reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4"
xref: Reactome:R-HSA-2161795 "Arachidonate is hydroxylated to 16-HETE by CYP(1)"
xref: Reactome:R-HSA-2161814 "Arachidonate is hydroxylated to 19-HETE by CYP(2)"
xref: Reactome:R-HSA-2161890 "Arachidonate is epoxidated to 5,6-EET by CYP(4)"
xref: Reactome:R-HSA-2161899 "Arachidonate is epoxidated to 8,9-EET by CYP(5)"
xref: Reactome:R-HSA-2161940 "Arachidonate is hydroxylated to 20-HETE by CYP(3)"
xref: Reactome:R-HSA-2162191 "Unknown enzyme hydroxylates DMPhOH"
xref: Reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ"
xref: Reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E"
xref: Reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1"
xref: Reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO"
xref: Reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1"
xref: Reactome:R-HSA-5602242 "Defective CYP2U1 does not omega-hydroxylate ARA"
xref: Reactome:R-HSA-5602272 "Defective CYP4F22 does not 20-hydroxylate TrXA3"
xref: Reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3"
xref: Reactome:R-HSA-5605147 "Defective CYP1B1 does not 4-hydroxylate EST17b"
xref: Reactome:R-HSA-5662662 "Tyrosinase oxidises tyrosine to dopaquinone"
xref: Reactome:R-HSA-5662692 "Dopa is oxidized to dopaquinone by TYR"
xref: Reactome:R-HSA-5663050 "DHI and DHICA polymerize forming eumelanin"
xref: Reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide"
xref: Reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl"
xref: Reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP"
xref: Reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)"
xref: Reactome:R-HSA-76416 "Benzene is hydroxylated to phenol"
xref: Reactome:R-HSA-76426 "N-atom dealkylation of caffeine"
xref: Reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical"
xref: Reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan"
xref: Reactome:R-HSA-76466 "CYP4A11 12-hydroxylates DDCX"
xref: Reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide"
xref: Reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2"
xref: Reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE"
xref: Reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1"
xref: Reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA"
xref: Reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2"
xref: Reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA"
xref: Reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA"
xref: Reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1"
xref: Reactome:R-HSA-9749986 "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA"
xref: Reactome:R-HSA-9750016 "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA"
xref: Reactome:R-HSA-9753285 "CYP2E1 monooxygenates APAP to NAPQI"
xref: Reactome:R-HSA-9756138 "CYP3A4 monooxygenates ATVL to 2-OH-ATVL"
xref: Reactome:R-HSA-9756162 "CYP3A4 monooxygenates ATV to 4-OH-ATV"
xref: Reactome:R-HSA-9756169 "CYP3A4 monooxygenates ATV to 2-OH-ATV"
xref: Reactome:R-HSA-9756180 "CYP3A4 monooxygenates ATVL to 4-OH-ATVL"
xref: Reactome:R-HSA-9915971 "Arachidonate is epoxidated to 11,12-EET by CYP(5)"
xref: Reactome:R-HSA-9915992 "Arachidonate is hydroxylated to 17-HETE by CYP(1)"
xref: Reactome:R-HSA-9915993 "Arachidonate is hydroxylated to 18-HETE by CYP(1)"
xref: Reactome:R-HSA-9915997 "Arachidonate is epoxidated to 14,15-EET by CYP(5)"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004498
name: calcidiol 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+." [EC:1.14.15.18, RHEA:20573]
synonym: "1-hydroxylase-25-hydroxyvitamin D3 activity" RELATED [EC:1.14.15.18]
synonym: "25-hydroxy D3-1alpha-hydroxylase activity" RELATED [EC:1.14.15.18]
synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" RELATED [EC:1.14.15.18]
synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" RELATED [EC:1.14.15.18]
synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" RELATED [EC:1.14.15.18]
synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" RELATED [EC:1.14.15.18]
synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" RELATED [EC:1.14.15.18]
synonym: "25-OHD-1 alpha-hydroxylase activity" RELATED [EC:1.14.15.18]
synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT []
synonym: "cytochrome P450 CYP27B" NARROW []
xref: EC:1.14.15.18
xref: KEGG_REACTION:R03610
xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-209868 "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D"
xref: Reactome:R-HSA-5602186 "Defective CYP27B1 does not hydroxylate CDL"
xref: RHEA:20573
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004499
name: N,N-dimethylaniline monooxygenase activity
namespace: molecular_function
alt_id: GO:0047076
def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [RHEA:24468]
synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" RELATED [EC:1.14.13.8]
synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT []
synonym: "dimethylaniline N-oxidase activity" RELATED [EC:1.14.13.8]
synonym: "dimethylaniline oxidase activity" RELATED [EC:1.14.13.8]
synonym: "DMA oxidase activity" RELATED [EC:1.14.13.8]
synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.14.13.8]
synonym: "flavin mixed function oxidase activity" RELATED [EC:1.14.13.8]
synonym: "flavin monooxygenase activity" RELATED [EC:1.14.13.8]
synonym: "flavin-containing monooxygenase activity" BROAD [EC:1.14.13.8]
synonym: "FMO activity" RELATED [EC:1.14.13.8]
synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT []
synonym: "mixed-function amine oxidase activity" RELATED [EC:1.14.13.8]
synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" RELATED [EC:1.14.13.8]
synonym: "Ziegler's enzyme" RELATED [EC:1.14.13.8]
xref: MetaCyc:1.14.13.8-RXN
xref: Reactome:R-HSA-139970 "FMO3:FAD N-oxidises TMA to TMAO"
xref: Reactome:R-HSA-217255 "FMO1:FAD N-oxidises TAM"
xref: Reactome:R-HSA-5602966 "Defective FMO3 does not N-oxidise TMA"
xref: RHEA:24468
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004500
name: dopamine beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]
synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" RELATED [EC:1.14.17.1]
synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" RELATED [EC:1.14.17.1]
synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" RELATED [EC:1.14.17.1]
synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" RELATED [EC:1.14.17.1]
synonym: "dopa beta-hydroxylase activity" RELATED [EC:1.14.17.1]
synonym: "dopamine b-hydroxylase activity" EXACT []
synonym: "dopamine beta-hydroxylase activity" RELATED [EC:1.14.17.1]
synonym: "dopamine beta-oxidase activity" RELATED [EC:1.14.17.1]
synonym: "dopamine hydroxylase activity" RELATED [EC:1.14.17.1]
synonym: "dopamine-B-hydroxylase activity" RELATED [EC:1.14.17.1]
synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1]
synonym: "oxygenase, dopamine beta-mono-" RELATED [EC:1.14.17.1]
synonym: "phenylamine beta-hydroxylase activity" RELATED [EC:1.14.17.1]
synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1]
xref: EC:1.14.17.1
xref: KEGG_REACTION:R02535
xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-209891 "Dopamine is oxidised to noradrenaline"
xref: RHEA:19117
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004501
name: ecdysone 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + ecdysone + O2 = 20-hydroxyecdysone + A + H2O." [EC:1.14.99.22, RHEA:14021]
synonym: "alpha-ecdysone C-20 hydroxylase activity" RELATED [EC:1.14.99.22]
synonym: "ecdysone 20-hydroxylase activity" EXACT []
synonym: "ecdysone modification" BROAD []
synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" RELATED [EC:1.14.99.22]
xref: EC:1.14.99.22
xref: KEGG_REACTION:R02374
xref: MetaCyc:RXN-18799
xref: RHEA:14021
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004502
name: kynurenine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+." [EC:1.14.13.9, RHEA:20545]
synonym: "kynurenine 3-hydroxylase activity" EXACT []
synonym: "kynurenine hydroxylase activity" RELATED [EC:1.14.13.9]
synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.9]
synonym: "L-kynurenine-3-hydroxylase activity" RELATED [EC:1.14.13.9]
xref: EC:1.14.13.9
xref: KEGG_REACTION:R01960
xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-71200 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O"
xref: RHEA:20545
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004503
name: tyrosinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates." [PMID:4965136, RHEA:18117]
comment: In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children.
synonym: "catecholase" RELATED []
synonym: "chlorogenic acid oxidase activity" RELATED []
synonym: "chlorogenic oxidase activity" RELATED []
synonym: "cresolase activity" RELATED [EC:1.14.18.1]
synonym: "dopa oxidase" RELATED []
synonym: "L-tyrosine monooxygenase activity" EXACT [GOC:bf]
synonym: "monophenol monooxidase activity" RELATED []
synonym: "monophenol monooxygenase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol oxidase activity" RELATED [EC:1.14.18.1]
synonym: "monophenol oxygenase" EXACT [EC:1.14.18.1, PMID:2494997]
synonym: "monophenolase activity" RELATED []
synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" RELATED [EC:1.14.18.1]
synonym: "o-diphenol oxidase activity" RELATED []
synonym: "o-diphenol oxidoreductase" RELATED []
synonym: "o-diphenol:O2 oxidoreductase activity" RELATED [EC:1.14.18.1]
synonym: "phenol oxidase activity" BROAD []
synonym: "phenolase activity" BROAD [EC:1.14.18.1]
synonym: "prophenol oxidase activity" RELATED [GOC:sart]
synonym: "prophenoloxidase activity" RELATED []
synonym: "pyrocatechol oxidase" BROAD []
synonym: "tyrosine-dopa oxidase activity" RELATED [EC:1.14.18.1]
xref: EC:1.14.18.1
xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004504
name: peptidylglycine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3]
synonym: "PAM activity" RELATED [EC:1.14.17.3]
synonym: "PAM-A" RELATED [EC:1.14.17.3]
synonym: "PAM-B" RELATED [EC:1.14.17.3]
synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3]
synonym: "peptide alpha-amide synthase activity" RELATED [EC:1.14.17.3]
synonym: "peptide-alpha-amide synthetase activity" RELATED [EC:1.14.17.3]
synonym: "peptidyl alpha-amidating enzyme activity" RELATED [EC:1.14.17.3]
synonym: "peptidylglycine 2-hydroxylase activity" EXACT []
synonym: "peptidylglycine alpha-amidating monooxygenase activity" RELATED [EC:1.14.17.3]
synonym: "peptidylglycine alpha-hydroxylase activity" RELATED [EC:1.14.17.3]
synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.17.3]
synonym: "synthase, peptide alpha-amide" RELATED [EC:1.14.17.3]
xref: EC:1.14.17.3
xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN
xref: RHEA:21452
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004505
name: phenylalanine 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [PMID:4004813, RHEA:20273]
synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.16.1]
synonym: "PAH activity" RELATED [EC:1.14.16.1]
synonym: "phenylalaninase activity" RELATED [EC:1.14.16.1]
synonym: "phenylalanine 4-hydroxylase activity" RELATED [EC:1.14.16.1]
synonym: "phenylalanine hydroxylase activity" EXACT []
xref: EC:1.14.16.1
xref: MetaCyc:RXN66-569
xref: Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr"
xref: Reactome:R-HSA-71118 "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr"
xref: RHEA:20273
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004506
name: squalene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+." [RHEA:25282]
synonym: "squalene 2,3-oxidocyclase activity" RELATED [EC:1.14.14.17]
synonym: "squalene epoxidase activity" RELATED [EC:1.14.14.17]
synonym: "squalene hydroxylase activity" RELATED [EC:1.14.14.17]
synonym: "squalene oxydocyclase activity" RELATED [EC:1.14.14.17]
synonym: "squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity" EXACT [KEGG_REACTION:R02874]
synonym: "squalene-2,3-epoxidase activity" RELATED [EC:1.14.14.17]
synonym: "squalene-2,3-epoxide cyclase activity" RELATED [EC:1.14.14.17]
xref: EC:1.14.14.17
xref: KEGG_REACTION:R02874
xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-191299 "Squalene is oxidized to its epoxide"
xref: RHEA:25282
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004507
name: steroid 11-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4]
synonym: "cytochrome P450 CYP11B1" NARROW []
synonym: "cytochrome P450 CYP11B2" NARROW []
synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4]
synonym: "oxygenase, steroid 11beta -mono-" RELATED [EC:1.14.15.4]
synonym: "steroid 11-beta-hydroxylase activity" EXACT []
synonym: "steroid 11-beta/18-hydroxylase activity" RELATED [EC:1.14.15.4]
synonym: "steroid 11beta-hydroxylase activity" RELATED [EC:1.14.15.4]
synonym: "steroid 11beta-monooxygenase activity" RELATED [EC:1.14.15.4]
synonym: "steroid 11beta/18-hydroxylase activity" RELATED [EC:1.14.15.4]
synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" RELATED [EC:1.14.15.4]
xref: EC:1.14.15.4
xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-193997 "CYP11B1 oxidises 11DCORT"
xref: Reactome:R-HSA-194017 "CYP11B2 oxidises 11DCORST to CORST"
xref: Reactome:R-HSA-5580292 "Defective CYP11B1 does not oxidise 11DCORT"
xref: Reactome:R-HSA-5600598 "Defective CYP11B2 does not oxidise 11DCORST"
xref: RHEA:15629
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004508
name: steroid 17-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:65760]
synonym: "17alpha-hydroxylase-C17,20 lyase activity" RELATED [EC:1.14.14.19]
synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.14.19]
synonym: "cytochrome P450 CYP17" NARROW []
synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.14.19]
synonym: "cytochrome P45017alpha" RELATED [EC:1.14.14.19]
synonym: "steroid 17-alpha-hydroxylase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" RELATED [EC:1.14.14.19]
synonym: "steroid 17alpha-hydroxylase activity" RELATED [EC:1.14.14.19]
synonym: "steroid 17alpha-monooxygenase activity" RELATED [EC:1.14.14.19]
synonym: "steroid 17alphahydroxylase/17,20 lyase activity" RELATED [EC:1.14.14.19]
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" RELATED [EC:1.14.14.19]
xref: EC:1.14.14.19
xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-193068 "CYP17A1 17-hydroxylates PREG"
xref: Reactome:R-HSA-193070 "CYP17A1 cleaves 17aHPREG to DHA"
xref: Reactome:R-HSA-193072 "CYP17A1 17-hydroxylates P4 to 17aHPROG"
xref: Reactome:R-HSA-193099 "CYP17A1 cleaves 17aHPROG to ANDST"
xref: Reactome:R-HSA-5601843 "Defective CYP17A1 does not 17-hydroxylate PREG"
xref: Reactome:R-HSA-9035954 "Defective CYP17A1 does not 17-hydroxylate P4"
xref: Reactome:R-HSA-9035956 "Defective CYP17A1 does not cleave 17aHPROG"
xref: RHEA:65760
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004509
name: steroid 21-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O." [RHEA:65612]
synonym: "21-hydroxylase activity" RELATED [EC:1.14.14.16]
synonym: "cytochrome P450 CYP21A1" NARROW []
synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.14.16]
synonym: "steroid 21-hydroxylase activity" EXACT []
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" RELATED [EC:1.14.14.16]
xref: EC:1.14.14.16
xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-5601976 "Defective CYP21A2 does not 21-hydroxylate PROG"
xref: RHEA:65612
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004510
name: tryptophan 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4]
synonym: "indoleacetic acid-5-hydroxylase activity" RELATED [EC:1.14.16.4]
synonym: "L-tryptophan hydroxylase activity" EXACT []
synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.16.4]
synonym: "tryptophan 5-hydroxylase activity" RELATED [EC:1.14.16.4]
synonym: "tryptophan hydroxylase activity" RELATED [EC:1.14.16.4]
xref: EC:1.14.16.4
xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-209828 "Tryptophan is hydroxylated"
xref: RHEA:16709
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004511
name: tyrosine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2]
synonym: "L-tyrosine hydroxylase activity" RELATED [EC:1.14.16.2]
synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.16.2]
synonym: "tyrosine 3-hydroxylase activity" EXACT []
synonym: "tyrosine hydroxylase activity" EXACT []
xref: EC:1.14.16.2
xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-209823 "Tyrosine is hydroxylated to dopa"
xref: RHEA:18201
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004512
name: inositol-3-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10716]
synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" RELATED [EC:5.5.1.4]
synonym: "D-glucose 6-phosphate cycloaldolase activity" RELATED [EC:5.5.1.4]
synonym: "glucocycloaldolase activity" RELATED [EC:5.5.1.4]
synonym: "glucose 6-phosphate cyclase activity" RELATED [EC:5.5.1.4]
synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" RELATED [EC:5.5.1.4]
synonym: "inositol 1-phosphate synthatase activity" RELATED [EC:5.5.1.4]
synonym: "inositol 1-phosphate synthetase activity" RELATED [EC:5.5.1.4]
xref: EC:5.5.1.4
xref: KEGG_REACTION:R07324
xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
xref: Reactome:R-HSA-1855178 "Glc6P is isomerised to I3P by ISYNA1 in the cytosol"
xref: RHEA:10716
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0004513
name: obsolete neolactotetraosylceramide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as GO:0008118 ; N-acetyllactosaminide alpha-2,3-sialyltransferase activity.
synonym: "alpha2->3 sialyltransferase activity" RELATED [EC:2.4.3.6]
synonym: "N-acetyllactosaminide alpha-2,3-sialyltransferase" BROAD [EC:2.4.3.6]
synonym: "neolactotetraosylceramide alpha-2,3-sialyltransferase" RELATED [EC:2.4.3.6]
is_obsolete: true
replaced_by: GO:0008118

[Term]
id: GO:0004514
name: nicotinate-nucleotide diphosphorylase (carboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate." [EC:2.4.2.19, RHEA:12733]
synonym: "NAD pyrophosphorylase activity" RELATED [EC:2.4.2.19]
synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" RELATED [EC:2.4.2.19]
synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT []
synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" RELATED [EC:2.4.2.19]
synonym: "QAPRTase activity" RELATED [EC:2.4.2.19]
synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" RELATED [EC:2.4.2.19]
synonym: "quinolinic acid phosphoribosyltransferase activity" RELATED [EC:2.4.2.19]
synonym: "quinolinic phosphoribosyltransferase activity" RELATED [EC:2.4.2.19]
xref: EC:2.4.2.19
xref: KEGG_REACTION:R03348
xref: MetaCyc:QUINOPRIBOTRANS-RXN
xref: Reactome:R-HSA-197268 "QPRT transfers PRIB to QUIN to form NAMN"
xref: RHEA:12733
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0004515
name: nicotinate-nucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18]
synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT []
synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" RELATED [EC:2.7.7.18]
synonym: "deamido-NAD(+) diphosphorylase activity" RELATED [EC:2.7.7.18]
synonym: "deamido-NAD(+) pyrophosphorylase activity" RELATED [EC:2.7.7.18]
synonym: "deamido-NAD+ pyrophosphorylase activity" RELATED [EC:2.7.7.18]
synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.18]
synonym: "NaMN-ATase activity" RELATED [EC:2.7.7.18]
synonym: "nicotinate mononucleotide adenylyltransferase activity" RELATED [EC:2.7.7.18]
synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW []
xref: EC:2.7.7.18
xref: MetaCyc:NICONUCADENYLYLTRAN-RXN
xref: Reactome:R-HSA-197235 "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD"
xref: Reactome:R-HSA-200474 "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD"
xref: Reactome:R-HSA-200512 "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD"
xref: RHEA:22860
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004516
name: nicotinate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate." [PMID:7503993]
synonym: "niacin ribonucleotidase activity" RELATED [EC:6.3.4.21]
synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:6.3.4.21]
synonym: "nicotinic acid mononucleotide glycohydrolase activity" RELATED [EC:6.3.4.21]
synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" RELATED [EC:6.3.4.21]
synonym: "nicotinic acid phosphoribosyltransferase activity" RELATED [EC:6.3.4.21]
xref: EC:6.3.4.21
xref: KEGG_REACTION:R01724
xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN
xref: Reactome:R-HSA-197186 "NAPRT1 dimer transfers PRIB to NCA to form NAMN"
xref: RHEA:36163
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004517
name: nitric-oxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897]
synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39]
synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39]
synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" RELATED [EC:1.14.13.39]
synonym: "NADPH-diaphorase activity" RELATED [EC:1.14.13.39]
synonym: "nitric oxide synthase activity" EXACT []
synonym: "nitric oxide synthetase activity" RELATED [EC:1.14.13.39]
synonym: "nitric-oxide synthetase activity" RELATED [EC:1.14.13.39]
synonym: "NO synthase activity" RELATED [EC:1.14.13.39]
xref: EC:1.14.13.39
xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
xref: Reactome:R-HSA-202127 "eNOS synthesizes NO"
xref: Reactome:R-HSA-418436 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)"
xref: RHEA:19897
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004518
name: nuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_plant
subset: goslim_yeast
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0004519
name: endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
xref: Reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near  insertion/deletion loop of 2 bases or more"
xref: Reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch"
xref: Reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER"
xref: Reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends"
xref: Reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end"
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004520
name: DNA endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
synonym: "DNA nicking activity" RELATED [GOC:mah]
synonym: "endodeoxyribonuclease activity" EXACT []
synonym: "endonuclease G activity" RELATED []
xref: Reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site"
xref: Reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop"
xref: Reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA"
xref: Reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ"
xref: Reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER"
xref: Reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)"
xref: Reactome:R-HSA-5693608 "Initial resection of double-strand break ends"
xref: Reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER"
xref: Reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER"
xref: Reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11"
is_a: GO:0004519 ! endonuclease activity
is_a: GO:0004536 ! DNA nuclease activity

[Term]
id: GO:0004521
name: RNA endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
synonym: "endonuclease G activity" RELATED []
synonym: "endoribonuclease activity" EXACT []
xref: Reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced"
xref: Reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs"
xref: Reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA"
xref: Reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA"
xref: Reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol"
xref: Reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA"
xref: Reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA"
xref: Reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA"
xref: Reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand"
xref: Reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA"
xref: Reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"
xref: Reactome:R-HSA-9708327 "ANG cleaves tRNA to yield tRNA halves"
xref: Reactome:R-HSA-9708812 "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)"
is_a: GO:0004519 ! endonuclease activity
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0004522
name: ribonuclease A activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.18]
synonym: "alkaline ribonuclease activity" EXACT []
synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT []
synonym: "endoribonuclease I" RELATED []
synonym: "gene S glycoproteins" RELATED []
synonym: "gene S locus-specific glycoproteins" RELATED []
synonym: "pancreatic ribonuclease activity" NARROW [EC:4.6.1.18]
synonym: "pancreatic RNase activity" RELATED [EC:4.6.1.18]
synonym: "ribonuclease I activity" RELATED [EC:4.6.1.18]
synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT []
synonym: "ribonucleic phosphatase activity" EXACT []
synonym: "RNase A activity" RELATED [EC:4.6.1.18]
synonym: "RNase activity" BROAD [EC:4.6.1.18]
synonym: "RNase I activity" RELATED [EC:4.6.1.18]
synonym: "S-genotype-assocd. glycoproteins" RELATED []
synonym: "SLSG glycoproteins" RELATED []
xref: EC:4.6.1.18
xref: Wikipedia:Ribonuclease_A
is_a: GO:0016892 ! RNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0004523
name: RNA-DNA hybrid ribonuclease activity
namespace: molecular_function
alt_id: GO:0004524
def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
synonym: "calf thymus ribonuclease H activity" EXACT []
synonym: "endoribonuclease H" RELATED [EC:3.1.26.4]
synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4]
synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4]
synonym: "hybrid nuclease activity" RELATED [EC:3.1.26.4]
synonym: "hybrid ribonuclease activity" RELATED [EC:3.1.26.4]
synonym: "hybridase (ribonuclease H)" RELATED [EC:3.1.26.4]
synonym: "hybridase activity" RELATED [EC:3.1.26.4]
synonym: "ribonuclease H activity" EXACT [GOC:vw]
synonym: "ribonuclease H1 activity" NARROW []
synonym: "ribonuclease H2 activity" NARROW []
synonym: "ribonuclease H3 activity" NARROW []
synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" RELATED [EC:3.1.26.4]
synonym: "RNase H activity" EXACT []
synonym: "RNase H1 activity" NARROW []
synonym: "RNase H2 activity" NARROW []
synonym: "RNase H3 activity" NARROW []
xref: EC:3.1.26.4
xref: MetaCyc:3.1.26.4-RXN
xref: Reactome:R-HSA-164519 "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex"
xref: Reactome:R-HSA-164528 "RNase H-mediated cleavage of the template strand"
xref: Reactome:R-HSA-173769 "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers"
xref: Reactome:R-HSA-182795 "RNase H-mediated degradation of the template strand"
xref: Reactome:R-HSA-182859 "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex"
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004525
name: ribonuclease III activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
synonym: "pre-mRNA 3'-end processing endonuclease" NARROW []
synonym: "ribonuclease 3 activity" RELATED [EC:3.1.26.3]
synonym: "RNase III activity" RELATED [EC:3.1.26.3]
xref: EC:3.1.26.3
xref: MetaCyc:3.1.26.3-RXN
xref: Reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA"
xref: Reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA"
xref: Reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"
xref: Reactome:R-HSA-9708292 "DICER1 cleaves tRNA"
xref: Reactome:R-HSA-9708408 "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid"
xref: Reactome:R-HSA-9820840 "DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA"
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters
is_a: GO:0032296 ! double-stranded RNA-specific ribonuclease activity

[Term]
id: GO:0004526
name: ribonuclease P activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]
synonym: "RNase P" EXACT []
synonym: "tRNA 5' leader endonuclease activity" EXACT []
xref: EC:3.1.26.5
xref: MetaCyc:3.1.26.5-RXN
xref: Reactome:R-HSA-5696810 "RNase P cleaves the 5' end of pre-tRNA"
xref: Wikipedia:RNase_P
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004527
name: exonuclease activity
namespace: molecular_function
alt_id: GO:0008857
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
synonym: "exonuclease IX activity" NARROW []
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004528
name: phosphodiesterase I activity
namespace: molecular_function
def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1]
synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" RELATED [EC:3.1.4.1]
synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1]
synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1]
synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "5'-PDase activity" RELATED [EC:3.1.4.1]
synonym: "5'-PDE activity" RELATED [EC:3.1.4.1]
synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "5'NPDE activity" RELATED [EC:3.1.4.1]
synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "exonuclease I activity" RELATED [EC:3.1.4.1]
synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" RELATED [EC:3.1.4.1]
synonym: "oligonucleate 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.1]
synonym: "orthophosphoric diester phosphohydrolase activity" RELATED [EC:3.1.4.1]
synonym: "PDE I activity" RELATED [EC:3.1.4.1]
synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1]
xref: EC:3.1.4.1
xref: MetaCyc:3.1.4.1-RXN
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004529
name: DNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684]
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0004536 ! DNA nuclease activity

[Term]
id: GO:0004530
name: deoxyribonuclease I activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1]
synonym: "alkaline deoxyribonuclease activity" RELATED [EC:3.1.21.1]
synonym: "alkaline DNase activity" RELATED [EC:3.1.21.1]
synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1]
synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1]
synonym: "deoxyribonucleic phosphatase activity" RELATED [EC:3.1.21.1]
synonym: "DNA depolymerase activity" RELATED [EC:3.1.21.1]
synonym: "DNA endonuclease activity" RELATED [EC:3.1.21.1]
synonym: "DNA nuclease activity" RELATED [EC:3.1.21.1]
synonym: "DNAase activity" RELATED [EC:3.1.21.1]
synonym: "DNase activity" NARROW [EC:3.1.21.1]
synonym: "DNase I" RELATED [EC:3.1.21.1]
synonym: "dornava" RELATED [EC:3.1.21.1]
synonym: "dornavac" RELATED [EC:3.1.21.1]
synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1]
synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1]
synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1]
synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1]
synonym: "pancreatic dornase" NARROW [EC:3.1.21.1]
synonym: "thymonuclease activity" NARROW [EC:3.1.21.1]
synonym: "thymonuclease, dornase activity" RELATED [EC:3.1.21.1]
xref: EC:3.1.21.1
xref: MetaCyc:3.1.21.1-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004531
name: deoxyribonuclease II activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1]
synonym: "acid deoxyribonuclease activity" RELATED [EC:3.1.22.1]
synonym: "acid DNase activity" RELATED [EC:3.1.22.1]
synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" RELATED [EC:3.1.22.1]
synonym: "DNase II activity" RELATED [EC:3.1.22.1]
synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1]
synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1]
xref: EC:3.1.22.1
xref: MetaCyc:3.1.22.1-RXN
is_a: GO:0016889 ! DNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0004532
name: RNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
synonym: "exoribonuclease activity" EXACT []
xref: Reactome:R-HSA-429961 "DCPS scavenges the 7-methylguanosine cap of mRNA"
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0004533
name: exoribonuclease H activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2]
synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2]
xref: EC:3.1.13.2
xref: MetaCyc:3.1.13.2-RXN
is_a: GO:0016896 ! RNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004534
name: 5'-3' RNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
synonym: "5'-3' exoribonuclease activity" EXACT []
xref: Reactome:R-HSA-429845 "5' to 3' exoribonuclease hydrolyzes decapped mRNA"
is_a: GO:0008409 ! 5'-3' exonuclease activity
is_a: GO:0016896 ! RNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004535
name: poly(A)-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4]
synonym: "3'-exoribonuclease activity" RELATED [EC:3.1.13.4]
synonym: "poly(A)-specific RNase activity" EXACT []
xref: EC:3.1.13.4
xref: MetaCyc:3.1.13.4-RXN
xref: Reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA"
xref: Reactome:R-HSA-429992 "PARN deadenylates mRNA"
xref: Reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA"
xref: Reactome:R-HSA-9822311 "CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP"
xref: Reactome:R-HSA-9822335 "CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA"
is_a: GO:0000175 ! 3'-5'-RNA exonuclease activity

[Term]
id: GO:0004536
name: DNA nuclease activity
namespace: molecular_function
alt_id: GO:0004537
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]
synonym: "caspase-activated deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activity" EXACT []
xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40"
xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2"
xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)"
is_a: GO:0004518 ! nuclease activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0004540
name: RNA nuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]
synonym: "ribonuclease activity" EXACT []
is_a: GO:0004518 ! nuclease activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0004549
name: tRNA-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah]
synonym: "tRNA-specific RNase activity" EXACT []
xref: Reactome:R-HSA-5696813 "TSEN complex cleaves the intron from pre-tRNA"
xref: Reactome:R-HSA-5696815 "ELAC2 cleaves the 3' end of pre-tRNA"
xref: Reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript"
xref: Reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript"
is_a: GO:0004540 ! RNA nuclease activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0004550
name: nucleoside diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.6]
synonym: "NDK activity" RELATED [EC:2.7.4.6]
synonym: "nucleoside 5'-diphosphate kinase activity" RELATED [EC:2.7.4.6]
synonym: "nucleoside 5'-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.6]
synonym: "nucleoside diphosphate (UDP) kinase activity" RELATED [EC:2.7.4.6]
synonym: "nucleoside diphosphokinase activity" RELATED [EC:2.7.4.6]
synonym: "nucleoside-diphosphate kinase activity" EXACT []
synonym: "nucleotide phosphate kinase activity" RELATED [EC:2.7.4.6]
synonym: "UDP kinase activity" RELATED [EC:2.7.4.6]
synonym: "uridine diphosphate kinase activity" RELATED [EC:2.7.4.6]
xref: EC:2.7.4.6
xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN
xref: Reactome:R-HSA-2162096 "carbovir diphosphate + ATP => carbovir triphosphate + ADP"
xref: Reactome:R-HSA-482619 "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)"
xref: Reactome:R-HSA-482621 "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)"
xref: Reactome:R-HSA-482804 "(d)NDP + ATP <=> (d)NTP + ADP (NME4)"
xref: Reactome:R-HSA-482812 "(d)NTP + ADP <=> (d)NDP + ATP (NME4)"
xref: Reactome:R-HSA-6806877 "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs"
xref: Reactome:R-HSA-9748969 "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP"
xref: Reactome:R-HSA-9748999 "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP"
xref: Reactome:R-HSA-9755013 "NME1,2 hexamers phosphorylate RBV-DP"
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0004551
name: dinucleotide phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [PMID:2848456, PMID:4405504]
synonym: "dinucleotide nucleotidohydrolase activity" RELATED []
synonym: "nucleotide diphosphatase activity" BROAD []
synonym: "nucleotide pyrophosphatase activity" EXACT []
xref: Reactome:R-HSA-196955 "2xENPP1 hydrolyzes FAD to FMN"
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004552
name: octanol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + H+ + NADH." [EC:1.1.1.73, RHEA:24620]
synonym: "1-octanol dehydrogenase activity" RELATED [EC:1.1.1.73]
synonym: "octanol dehydrogenase activity" BROAD []
synonym: "octanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.73]
xref: EC:1.1.1.73
xref: KEGG_REACTION:R02878
xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN
xref: RHEA:24620
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0004553
name: hydrolase activity, hydrolyzing O-glycosyl compounds
namespace: molecular_function
alt_id: GO:0016800
def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
synonym: "O-glucosyl hydrolase activity" EXACT []
xref: EC:3.2.1.-
xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG"
xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP"
xref: Reactome:R-HSA-9661820 "Bacterial GUSB hydrolyses BDG to BIL"
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0004555
name: alpha,alpha-trehalase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [PMID:19897915, RHEA:32675]
synonym: "alpha,alpha-trehalose glucohydrolase activity" RELATED [EC:3.2.1.28]
xref: EC:3.2.1.28
xref: MetaCyc:TREHALA-RXN
xref: Reactome:R-HSA-188985 "trehalose + H2O => 2 D-glucose"
xref: RHEA:32675
is_a: GO:0015927 ! trehalase activity

[Term]
id: GO:0004556
name: alpha-amylase activity
namespace: molecular_function
alt_id: GO:0103025
def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [PMID:12527308]
synonym: "1,4-alpha-D-glucan glucanohydrolase activity" RELATED []
synonym: "alpha amylase activity" RELATED []
synonym: "alpha-amylase activity (releasing maltohexaose)" NARROW []
synonym: "endoamylase activity" RELATED []
synonym: "glycogenase activity" BROAD [EC:3.2.1.1]
synonym: "taka-amylase A" RELATED []
xref: EC:3.2.1.1
xref: MetaCyc:ALPHA-AMYL-RXN
xref: Reactome:R-HSA-188979 "Digestion of linear starch (amylose) by extracellular amylase"
xref: Reactome:R-HSA-191114 "Digestion of branched starch (amylopectin) by extracellular amylase"
is_a: GO:0016160 ! amylase activity

[Term]
id: GO:0004557
name: alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids." [EC:3.2.1.22]
synonym: "alpha-D-galactosidase activity" RELATED [EC:3.2.1.22]
synonym: "melibiase activity" EXACT [EC:3.2.1.22]
xref: EC:3.2.1.22
xref: MetaCyc:ALPHAGALACTOSID-RXN
xref: Reactome:R-HSA-1605736 "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE"
xref: Reactome:R-HSA-9841189 "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE"
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0004558
name: alpha-1,4-glucosidase activity
namespace: molecular_function
alt_id: GO:0004562
alt_id: GO:0016982
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20]
synonym: "acid maltase activity" RELATED [EC:3.2.1.20]
synonym: "alpha-D-glucosidase activity" RELATED [EC:3.2.1.20]
synonym: "alpha-D-glucoside glucohydrolase activity" RELATED [EC:3.2.1.20]
synonym: "alpha-glucopyranosidase activity" RELATED [EC:3.2.1.20]
synonym: "alpha-glucoside hydrolase activity" RELATED [EC:3.2.1.20]
synonym: "glucoinvertase activity" RELATED [EC:3.2.1.20]
synonym: "glucosidoinvertase activity" RELATED [EC:3.2.1.20]
synonym: "glucosidosucrase activity" RELATED [EC:3.2.1.20]
synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20]
synonym: "maltase-glucoamylase activity" RELATED [EC:3.2.1.20]
xref: EC:3.2.1.20
xref: MetaCyc:MALTODEXGLUCOSID-RXN
xref: Reactome:R-HSA-189053 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose"
xref: Reactome:R-HSA-189102 "maltose + H2O => 2 D-glucose (maltase-glucoamylase)"
xref: Reactome:R-HSA-191101 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)"
xref: Reactome:R-HSA-191108 "maltose + H2O => 2 D-glucose (sucrase-isomaltase)"
xref: Reactome:R-HSA-191116 "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)"
xref: Reactome:R-HSA-5659861 "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)"
xref: Reactome:R-HSA-5659879 "Defective SI does not hydrolyze iMal"
xref: Reactome:R-HSA-5659899 "Defective SI does not hydrolyze maltotriose"
xref: Reactome:R-HSA-5659922 "Defective SI does not hydrolyze Mal"
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004559
name: alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]
synonym: "1,2-alpha-D-mannosidase activity" NARROW [EC:3.2.1.24]
synonym: "1,2-alpha-mannosidase" NARROW [EC:3.2.1.24]
synonym: "alpha-D-mannopyranosidase activity" RELATED [EC:3.2.1.24]
synonym: "alpha-D-mannosidase activity" RELATED [EC:3.2.1.24]
synonym: "alpha-D-mannoside mannohydrolase activity" RELATED [EC:3.2.1.24]
synonym: "exo-alpha-mannosidase activity" RELATED [EC:3.2.1.24]
synonym: "p-nitrophenyl-alpha-mannosidase activity" NARROW [EC:3.2.1.24]
xref: EC:3.2.1.24
xref: MetaCyc:3.2.1.24-RXN
xref: Reactome:R-HSA-6799545 "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5"
xref: Reactome:R-HSA-8853686 "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3"
xref: Reactome:R-HSA-9694656 "Spike trimer glycoside chains are extended"
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0004560
name: alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51]
synonym: "alpha-fucosidase activity" RELATED [EC:3.2.1.51]
synonym: "alpha-L-fucoside fucohydrolase activity" RELATED [EC:3.2.1.51]
xref: EC:3.2.1.51
xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN
xref: Reactome:R-HSA-5693807 "FUCA1 hydrolyses NGP:1,6-GlcNAc"
xref: RHEA:12288
is_a: GO:0015928 ! fucosidase activity

[Term]
id: GO:0004561
name: alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50]
synonym: "alpha-acetylglucosaminidase activity" RELATED [EC:3.2.1.50]
synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" RELATED [EC:3.2.1.50]
synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" RELATED [EC:3.2.1.50]
synonym: "N-acetyl-alpha-D-glucosaminidase activity" RELATED [EC:3.2.1.50]
synonym: "N-acetyl-alpha-glucosaminidase activity" RELATED [EC:3.2.1.50]
synonym: "NAG activity" RELATED [EC:3.2.1.50]
xref: EC:3.2.1.50
xref: MetaCyc:3.2.1.50-RXN
xref: Reactome:R-HSA-1678742 "NAGLU hydrolyses Heparan sulfate chain(4)"
xref: Reactome:R-HSA-2090038 "NAGLU hydrolyses heparan chain(2)"
xref: Reactome:R-HSA-2263496 "Defective NAGLU does not hydrolyse Heparan sulfate chain(4)"
xref: Reactome:R-HSA-9036052 "Defective NAGLU does not hydrolyse heparan chain(2)"
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004563
name: beta-N-acetylhexosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]
synonym: "beta-acetylaminodeoxyhexosidase activity" RELATED [EC:3.2.1.52]
synonym: "beta-acetylhexosaminidinase activity" RELATED [EC:3.2.1.52]
synonym: "beta-D-hexosaminidase activity" RELATED [EC:3.2.1.52]
synonym: "beta-D-N-acetylhexosaminidase activity" RELATED [EC:3.2.1.52]
synonym: "beta-hexosaminidase activity" RELATED [EC:3.2.1.52]
synonym: "beta-N-acetyl-D-hexosaminidase activity" RELATED [EC:3.2.1.52]
synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" RELATED [EC:3.2.1.52]
synonym: "hexosaminidase A" RELATED [EC:3.2.1.52]
synonym: "N-acetyl-beta-D-hexosaminidase activity" RELATED [EC:3.2.1.52]
synonym: "N-acetyl-beta-glucosaminidase activity" RELATED [EC:3.2.1.52]
synonym: "N-acetyl-beta-hexosaminidase activity" RELATED [EC:3.2.1.52]
synonym: "N-acetylhexosaminidase activity" RELATED [EC:3.2.1.52]
xref: EC:3.2.1.52
xref: MetaCyc:3.2.1.52-RXN
xref: Reactome:R-HSA-1605595 "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3"
xref: Reactome:R-HSA-1605632 "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE"
xref: Reactome:R-HSA-1638053 "HEXA cleaves the terminal GalNAc from keratan sulfate"
xref: Reactome:R-HSA-2105001 "HEXA cleaves the terminal GalNAc from DS"
xref: Reactome:R-HSA-2162225 "HEXA cleaves the terminal GalNAc from small HA fragments"
xref: Reactome:R-HSA-3656259 "Defective HEXA does not cleave the terminal GalNAc from DS"
xref: Reactome:R-HSA-3662344 "Defective HEXB does not cleave the terminal GalNAc from DS"
xref: Reactome:R-HSA-9035976 "Defective HEXA does not cleave the terminall GalNAc from small HA fragments"
xref: Reactome:R-HSA-9035978 "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate"
xref: Reactome:R-HSA-9035982 "Defective HEXB does not cleave the terminal GalNAc from HA fragments"
xref: Reactome:R-HSA-9035983 "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate"
xref: Reactome:R-HSA-9638075 "HEXB cleaves the terminal GalNAc from DS"
xref: Reactome:R-HSA-9638076 "HEXB cleaves the terminal GalNAc from small HA fragments"
xref: Reactome:R-HSA-9638078 "HEXB cleaves the terminal GalNAc from keratan sulfate"
xref: Reactome:R-HSA-9840833 "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer"
xref: Reactome:R-HSA-9840884 "bHEXA,bHEXS hydrolyze GM2A:SM2"
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004564
name: beta-fructofuranosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985]
synonym: "acid invertase activity" BROAD []
synonym: "alkaline invertase activity" BROAD []
synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT []
synonym: "beta-fructosidase activity" RELATED []
synonym: "beta-h-fructosidase activity" RELATED []
synonym: "fructosylinvertase activity" RELATED []
synonym: "glucosucrase activity" RELATED []
synonym: "invertase activity" BROAD []
synonym: "invertin activity" BROAD []
synonym: "maxinvert L 1000 activity" RELATED []
synonym: "saccharase activity" RELATED []
xref: EC:3.2.1.26
xref: MetaCyc:RXN-9985
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004565
name: beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]
comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase.
synonym: "beta-D-galactanase activity" RELATED []
synonym: "beta-D-galactoside galactohydrolase activity" RELATED []
synonym: "beta-D-lactosidase activity" RELATED []
synonym: "beta-lactosidase activity" RELATED []
synonym: "exo-(1->4)-beta-D-galactanase activity" RELATED [EC:3.2.1.23]
synonym: "hydrolact" RELATED []
xref: EC:3.2.1.23
xref: MetaCyc:3.2.1.23-RXN
xref: Reactome:R-HSA-1605624 "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2"
xref: Reactome:R-HSA-1606312 "GLB1 hydrolyzes SapB/C:LacCer"
xref: Reactome:R-HSA-1630306 "GLB1 hydrolyses a glycosaminoglycan"
xref: Reactome:R-HSA-1793217 "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase"
xref: Reactome:R-HSA-2090079 "GLB1 hydrolyses linker chain(2)"
xref: Reactome:R-HSA-2265534 "Defective GLB1 does not hydrolyse a glycosaminoglycan"
xref: Reactome:R-HSA-9036061 "Defective GLB1 does not hydrolyse linker chain(2)"
xref: Reactome:R-HSA-9840795 "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2"
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0004566
name: beta-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]
synonym: "beta-D-glucuronoside glucuronosohydrolase activity" RELATED [EC:3.2.1.31]
synonym: "beta-glucuronide glucuronohydrolase activity" RELATED [EC:3.2.1.31]
synonym: "exo-beta-D-glucuronidase activity" RELATED [EC:3.2.1.31]
synonym: "glucuronidase activity" RELATED [EC:3.2.1.31]
synonym: "ketodase activity" RELATED [EC:3.2.1.31]
xref: EC:3.2.1.31
xref: MetaCyc:BETA-GLUCURONID-RXN
xref: Reactome:R-HSA-1678854 "GUSB tetramer hydrolyses CS/HS precursor"
xref: Reactome:R-HSA-2162226 "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc"
xref: Reactome:R-HSA-2162227 "GUSB tetramer hydrolyses (HA)2"
xref: Reactome:R-HSA-2318373 "Defective GUSB does not hydrolyse (HA)2"
xref: Reactome:R-HSA-9036068 "Defective GUSB does not hydrolyse GlcA-1,3-GlcNAc"
xref: Reactome:R-HSA-9036070 "Defective GUSB does not hydrolyse CS/HS precursor"
xref: RHEA:17633
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004567
name: beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25]
synonym: "beta-D-mannosidase activity" RELATED [EC:3.2.1.25]
synonym: "beta-D-mannoside mannohydrolase activity" RELATED [EC:3.2.1.25]
synonym: "beta-mannoside mannohydrolase activity" RELATED [EC:3.2.1.25]
synonym: "exo-beta-D-mannanase activity" RELATED [EC:3.2.1.25]
synonym: "mannanase activity" RELATED [EC:3.2.1.25]
synonym: "mannase activity" RELATED [EC:3.2.1.25]
xref: EC:3.2.1.25
xref: MetaCyc:3.2.1.25-RXN
xref: Reactome:R-HSA-8853710 "MANBA hydrolyses GlcNAc:Man"
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0004568
name: chitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
xref: Reactome:R-HSA-6786421 "CHIA hydrolyses chitin"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004569
name: glycoprotein endo-alpha-1,2-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130]
synonym: "endo-alpha-mannosidase activity" RELATED [EC:3.2.1.130]
synonym: "endomannosidase activity" RELATED [EC:3.2.1.130]
synonym: "glucosyl mannosidase activity" RELATED [EC:3.2.1.130]
synonym: "glucosylmannosidase activity" RELATED [EC:3.2.1.130]
synonym: "glycoprotein glucosylmannohydrolase activity" RELATED [EC:3.2.1.130]
xref: EC:3.2.1.130
xref: MetaCyc:3.2.1.130-RXN
xref: Reactome:R-HSA-964759 "Alternative endo-mannosidase I route"
xref: RHEA:54824
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0004571
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]
synonym: "1,2-alpha-mannosidase" RELATED [EC:3.2.1.113]
synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" RELATED [EC:3.2.1.113]
synonym: "exo-alpha-1,2-mannanase activity" RELATED [EC:3.2.1.113]
synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113]
synonym: "Man9-mannosidase activity" NARROW [EC:3.2.1.113]
synonym: "ManI activity" NARROW [EC:3.2.1.113]
synonym: "mannose-9 processing alpha-mannosidase activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase I" RELATED [EC:3.2.1.113]
xref: EC:3.2.1.113
xref: KEGG_REACTION:R12479
xref: Reactome:R-HSA-4793949 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)"
xref: Reactome:R-HSA-6782685 "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5"
xref: Reactome:R-HSA-901024 "MAN1B1 hydrolyses 1,2-linked mannose (a branch)"
xref: Reactome:R-HSA-901036 "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)"
xref: Reactome:R-HSA-901039 "MAN1B1 hydrolyses 1,2-linked mannose (c branch)"
xref: Reactome:R-HSA-901074 "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)"
xref: Reactome:R-HSA-9036008 "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)"
xref: Reactome:R-HSA-9036011 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)"
xref: Reactome:R-HSA-9036012 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)"
xref: Reactome:R-HSA-964737 "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2"
xref: Reactome:R-HSA-964825 "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2"
xref: Reactome:R-HSA-964830 "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2"
xref: Reactome:R-HSA-9696807 "N-glycan mannose trimming of Spike"
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0004572
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114]
synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" RELATED [EC:3.2.1.114]
synonym: "alpha-(1,3/6)-mannosidase activity" RELATED [EC:3.2.1.114]
synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "exo-1,3-1,6-alpha-mannosidase activity" RELATED [EC:3.2.1.114]
synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" RELATED [EC:3.2.1.114]
synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "ManII activity" NARROW [EC:3.2.1.114]
synonym: "mannosidase II activity" NARROW [EC:3.2.1.114]
synonym: "mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity" EXACT []
synonym: "mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity" EXACT []
synonym: "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity" EXACT []
xref: EC:3.2.1.114
xref: MetaCyc:3.2.1.114-RXN
xref: Reactome:R-HSA-975814 "Trimming of mannoses on the alpha1,6 arm by MAN2A1"
xref: RHEA:56052
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0004573
name: Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
namespace: molecular_function
def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106]
synonym: "mannosyl-oligosaccharide glucohydrolase activity" RELATED [EC:3.2.1.106]
synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT []
synonym: "mannosyl-oligosaccharide glucosidase activity" RELATED [EC:3.2.1.106]
synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106]
synonym: "trimming glucosidase I" EXACT [EC:3.2.1.106]
xref: EC:3.2.1.106
xref: MetaCyc:3.2.1.106-RXN
xref: Reactome:R-HSA-4793947 "Defective MOGS does not cleave glucose from an N-glycosylated protein"
xref: Reactome:R-HSA-532678 "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase"
xref: Reactome:R-HSA-9694364 "N-glycan glucose trimming of Spike"
xref: RHEA:55988
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004574
name: oligo-1,6-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose." [EC:3.2.1.10]
synonym: "alpha-limit dextrinase activity" RELATED [EC:3.2.1.10]
synonym: "alpha-methylglucosidase activity" RELATED [GOC:rb]
synonym: "dextrin 6-glucanohydrolase activity" RELATED [EC:3.2.1.10]
synonym: "dextrin 6alpha-glucanohydrolase activity" RELATED [EC:3.2.1.10]
synonym: "exo-oligo-1,6-glucosidase activity" RELATED [EC:3.2.1.10]
synonym: "isomaltase activity" RELATED [EC:3.2.1.10]
synonym: "limit dextrinase" RELATED []
synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" RELATED [EC:3.2.1.10]
synonym: "oligosaccharide alpha-1,6-glucosidase activity" RELATED [EC:3.2.1.10]
synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10]
xref: EC:3.2.1.10
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004575
name: sucrose alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [RHEA:33795]
synonym: "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis" BROAD []
synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis" BROAD []
synonym: "intestinal sucrase activity" RELATED [EC:3.2.1.48]
synonym: "sucrase activity" RELATED [EC:3.2.1.48]
synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48]
synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48]
synonym: "sucrose alpha-D-glucohydrolase activity" EXACT []
synonym: "sucrose alpha-glucohydrolase activity" RELATED [EC:3.2.1.48]
synonym: "sucrose hydrolysis" BROAD []
synonym: "sucrose-alpha-D-glucohydrolase activity" RELATED [EC:3.2.1.48]
xref: EC:3.2.1.48
xref: KEGG_REACTION:R00802
xref: MetaCyc:3.2.1.48-RXN
xref: Reactome:R-HSA-189069 "sucrose + H2O => glucose + fructose"
xref: Reactome:R-HSA-5659926 "Defective SI does not hydrolyze Suc"
xref: RHEA:33795
is_a: GO:0004564 ! beta-fructofuranosidase activity
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004576
name: oligosaccharyl transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
synonym: "oligosaccharide transferase activity" EXACT [GOC:mah]
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0004577
name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141]
synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" RELATED [EC:2.4.1.141]
synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" RELATED [EC:2.4.1.141]
synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.141]
synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.141]
xref: EC:2.4.1.141
xref: MetaCyc:2.4.1.141-RXN
xref: Reactome:R-HSA-446207 "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP"
xref: Reactome:R-HSA-5633241 "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP"
xref: RHEA:23380
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004578
name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142]
synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" RELATED [EC:2.4.1.142]
synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.142]
synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" RELATED [EC:2.4.1.142]
xref: EC:2.4.1.142
xref: MetaCyc:2.4.1.142-RXN
xref: Reactome:R-HSA-446218 "Addition of the first mannose to the N-glycan precursor by ALG1"
xref: Reactome:R-HSA-4549382 "Defective ALG1 does not transfer the first Man to the N-glycan precursor"
xref: RHEA:13865
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0004579
name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [RHEA:22980]
synonym: "asparagine N-glycosyltransferase activity" EXACT []
synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT []
synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT []
synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT []
synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT []
synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT []
synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT []
synonym: "oligomannosyltransferase activity" RELATED []
xref: EC:2.4.99.18
xref: MetaCyc:RXN-16761
xref: Reactome:R-HSA-446209 "Transfer of N-glycan to the protein"
xref: Reactome:R-HSA-9694793 "Spike protein gets N-glycosylated"
xref: RHEA:22980
is_a: GO:0004576 ! oligosaccharyl transferase activity

[Term]
id: GO:0004581
name: dolichyl-phosphate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117]
synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.117]
synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" RELATED [EC:2.4.1.117]
xref: EC:2.4.1.117
xref: MetaCyc:2.4.1.117-RXN
xref: Reactome:R-HSA-446214 "Synthesis of dolichyl-phosphate-glucose"
xref: RHEA:15401
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0004582
name: dolichyl-phosphate beta-D-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83]
synonym: "dolichol phosphate mannose synthase activity" RELATED [EC:2.4.1.83]
synonym: "dolichol-phosphate mannose synthase activity" RELATED [EC:2.4.1.83]
synonym: "dolichol-phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "dolichol-phosphate-mannose synthase activity" EXACT []
synonym: "dolichyl mannosyl phosphate synthase activity" RELATED [EC:2.4.1.83]
synonym: "dolichyl phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "dolichyl-phosphate mannose synthase activity" RELATED [EC:2.4.1.83]
synonym: "dolichyl-phospho-mannose synthase activity" RELATED [EC:2.4.1.83]
synonym: "DPM synthase activity" EXACT []
synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "GDPMan:DolP mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83]
synonym: "mannosylphosphodolichol synthase activity" RELATED [EC:2.4.1.83]
synonym: "mannosylphosphoryldolichol synthase activity" RELATED [EC:2.4.1.83]
xref: EC:2.4.1.83
xref: MetaCyc:2.4.1.83-RXN
xref: Reactome:R-HSA-162721 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose"
xref: Reactome:R-HSA-4717406 "Defective DPM1 does not transfer mannose to DOLP to form DOLPman"
xref: Reactome:R-HSA-4719354 "Defective DPM3 does not transfer mannose to DOLP to form DOLPman"
xref: Reactome:R-HSA-4719375 "Defective DPM2 does not transfer mannose to DOLP to form DOLPman"
xref: RHEA:21184
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004583
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah]
xref: MetaCyc:RXN-5472
xref: Reactome:R-HSA-446189 "Addition of a second glucose to the N-glycan precursor by ALG8"
xref: Reactome:R-HSA-446194 "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue"
xref: Reactome:R-HSA-446202 "Addition of the first glucose to the N-glycan precursor by ALG6"
xref: Reactome:R-HSA-4724291 "Defective ALG6 does not add glucose to the N-glycan precursor"
xref: Reactome:R-HSA-4724330 "Defective ALG8 does not add glucose to the N-glycan precursor"
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0004584
name: obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130]
comment: The reason for obsoletion is that this activity has been replaced by 4 activities in EC, EC:2.4.1.258, EC:2.4.1.259, EC:2.4.1.260, and EC:2.4.1.261.
synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.130]
synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.130]
synonym: "oligomannosylsynthase activity" BROAD [EC:2.4.1.130]
is_obsolete: true
consider: GO:0052917
consider: GO:0052918
consider: GO:0052925
consider: GO:0052926

[Term]
id: GO:0004585
name: ornithine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3]
synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.3]
synonym: "carbamylphosphate-ornithine transcarbamylase activity" RELATED [EC:2.1.3.3]
synonym: "citrulline phosphorylase activity" RELATED [EC:2.1.3.3]
synonym: "L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.3]
synonym: "L-ornithine carbamyltransferase activity" RELATED [EC:2.1.3.3]
synonym: "L-ornithine transcarbamylase activity" RELATED [EC:2.1.3.3]
synonym: "ornithine carbamyltransferase activity" RELATED [EC:2.1.3.3]
synonym: "ornithine transcarbamylase activity" RELATED [EC:2.1.3.3]
synonym: "OTC activity" RELATED [EC:2.1.3.3]
synonym: "OTCase activity" RELATED [EC:2.1.3.3]
xref: EC:2.1.3.3
xref: MetaCyc:ORNCARBAMTRANSFER-RXN
xref: Reactome:R-HSA-70560 "carbamoyl phosphate + ornithine => citrulline + orthophosphate"
xref: RHEA:19513
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0004586
name: ornithine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine." [EC:4.1.1.17, RHEA:22964]
synonym: "L-ornithine carboxy-lyase (putrescine-forming)" RELATED [EC:4.1.1.17]
synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17]
synonym: "SpeC" RELATED [EC:4.1.1.17]
xref: EC:4.1.1.17
xref: KEGG_REACTION:R00670
xref: MetaCyc:ORNDECARBOX-RXN
xref: Reactome:R-HSA-70692 "ornithine => putrescine + CO2"
xref: RHEA:22964
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004587
name: ornithine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde." [EC:2.6.1.13]
synonym: "GabT" RELATED [EC:2.6.1.13]
synonym: "L-ornithine 5-aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "L-ornithine aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "L-ornithine:2-oxo-acid aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "OAT" RELATED [EC:2.6.1.13]
synonym: "ornithine 5-aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine delta-transaminase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine ketoacid aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine transaminase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine(lysine) transaminase activity" RELATED []
synonym: "ornithine--2-oxoacid aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine--keto acid aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine--keto acid transaminase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine--ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine--oxo acid aminotransferase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine--oxo-acid transaminase activity" RELATED [EC:2.6.1.13]
synonym: "ornithine-oxo-acid aminotransferase activity" EXACT []
synonym: "ornithine-oxo-acid transaminase activity" RELATED []
synonym: "ornithine:alpha-oxoglutarate transaminase activity" RELATED [EC:2.6.1.13]
xref: EC:2.6.1.13
xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-70654 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]"
xref: Reactome:R-HSA-70666 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]"
xref: RHEA:13877
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004588
name: orotate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]
synonym: "OPRT activity" RELATED [EC:2.4.2.10]
synonym: "OPRTase activity" RELATED [EC:2.4.2.10]
synonym: "orotate phosphoribosyl pyrophosphate transferase activity" RELATED [EC:2.4.2.10]
synonym: "orotic acid phosphoribosyltransferase activity" RELATED [EC:2.4.2.10]
synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidine monophosphate pyrophosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidine phosphoribosyltransferase activity" RELATED [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate diphosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" RELATED [EC:2.4.2.10]
synonym: "orotidylate phosphoribosyltransferase activity" RELATED [EC:2.4.2.10]
synonym: "orotidylate pyrophosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidylic acid phosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidylic acid pyrophosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidylic phosphorylase activity" RELATED [EC:2.4.2.10]
synonym: "orotidylic pyrophosphorylase activity" RELATED [EC:2.4.2.10]
xref: EC:2.4.2.10
xref: MetaCyc:OROPRIBTRANS-RXN
xref: Reactome:R-HSA-73567 "UMPS dimer transfers phosphoribosyl group to ORO to form OMP"
xref: RHEA:10380
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0004589
name: dihydroorotate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + NAD+ = H+ + NADH + orotate." [RHEA:13513]
synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.14]
synonym: "orotate reductase (NADH) activity" EXACT []
xref: EC:1.3.1.14
xref: KEGG_REACTION:R01869
xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN
xref: RHEA:13513
is_a: GO:0004152 ! dihydroorotate dehydrogenase activity
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004590
name: orotidine-5'-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP." [EC:4.1.1.23, RHEA:11596]
synonym: "ODCase activity" RELATED [EC:4.1.1.23]
synonym: "OMP decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "OMP-DC" RELATED [EC:4.1.1.23]
synonym: "OMPdcase activity" RELATED [EC:4.1.1.23]
synonym: "orotate decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotate monophosphate decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotic decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotidine 5'-phosphate decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotidine monophosphate decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotidine phosphate decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotidine-5'-monophosphate decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" RELATED [EC:4.1.1.23]
synonym: "orotidine-5'-phosphate carboxy-lyase activity" RELATED [EC:4.1.1.23]
synonym: "orotidylic acid decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotidylic decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "orotodylate decarboxylase activity" RELATED [EC:4.1.1.23]
synonym: "UMP synthase activity" RELATED [EC:4.1.1.23]
synonym: "uridine 5'-monophosphate synthase activity" RELATED [EC:4.1.1.23]
xref: EC:4.1.1.23
xref: KEGG_REACTION:R00965
xref: MetaCyc:OROTPDECARB-RXN
xref: Reactome:R-HSA-73564 "UMPS dimer decarboxylates OMP to UMP"
xref: RHEA:11596
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004591
name: oxoglutarate dehydrogenase (succinyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]
synonym: "2-ketoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2]
synonym: "2-oxoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2]
synonym: "2-oxoglutarate: lipoate oxidoreductase activity" RELATED [EC:1.2.4.2]
synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" RELATED [EC:1.2.4.2]
synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" RELATED [EC:1.2.4.2]
synonym: "AKGDH activity" RELATED [EC:1.2.4.2]
synonym: "alpha-ketoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2]
synonym: "alpha-ketoglutaric acid dehydrogenase activity" RELATED [EC:1.2.4.2]
synonym: "alpha-ketoglutaric dehydrogenase activity" RELATED [EC:1.2.4.2]
synonym: "alpha-oxoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2]
synonym: "ketoglutaric dehydrogenase activity" RELATED [EC:1.2.4.2]
synonym: "OGDC activity" RELATED [EC:1.2.4.2]
synonym: "oxoglutarate decarboxylase activity" RELATED [EC:1.2.4.2]
synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT []
synonym: "oxoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2]
xref: EC:1.2.4.2
xref: MetaCyc:2OXOGLUTDECARB-RXN
xref: Reactome:R-HSA-71401 "OGDH dimer decarboxylates 2-OG"
xref: RHEA:12188
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0004592
name: pantoate-beta-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1]
synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" RELATED [EC:6.3.2.1]
synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" RELATED [EC:6.3.2.1]
synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1]
synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1]
synonym: "pantothenate synthetase activity" RELATED [EC:6.3.2.1]
xref: EC:6.3.2.1
xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN
xref: RHEA:10912
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004593
name: pantothenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantothenate + H2O = (R)-pantoate + beta-alanine." [EC:3.5.1.22, RHEA:12448]
synonym: "(R)-pantothenate amidohydrolase activity" RELATED [EC:3.5.1.22]
synonym: "pantothenate amidohydrolase activity" RELATED [EC:3.5.1.22]
synonym: "pantothenate hydrolase activity" RELATED [EC:3.5.1.22]
xref: EC:3.5.1.22
xref: KEGG_REACTION:R02474
xref: MetaCyc:PANTOTHENASE-RXN
xref: RHEA:12448
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004594
name: pantothenate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]
synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" RELATED [EC:2.7.1.33]
synonym: "ATP:pantothenate 4'-phosphotransferase activity" RELATED [EC:2.7.1.33]
synonym: "D-pantothenate kinase activity" RELATED [EC:2.7.1.33]
synonym: "pantothenate kinase (phosphorylating) activity" RELATED [EC:2.7.1.33]
synonym: "pantothenic acid kinase activity" RELATED [EC:2.7.1.33]
xref: EC:2.7.1.33
xref: MetaCyc:PANTOTHENATE-KIN-RXN
xref: Reactome:R-HSA-196857 "PANK2 phosphorylates PanK"
xref: Reactome:R-HSA-199203 "PANK1/3 phosphorylate PanK"
xref: RHEA:16373
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004595
name: pantetheine-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate." [EC:2.7.7.3, RHEA:19801]
synonym: "3'-dephospho-CoA pyrophosphorylase activity" RELATED [EC:2.7.7.3]
synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.3]
synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT []
synonym: "dephospho-CoA diphosphorylase activity" RELATED [EC:2.7.7.3]
synonym: "dephospho-CoA pyrophosphorylase activity" RELATED [EC:2.7.7.3]
synonym: "dephospho-coenzyme A pyrophosphorylase activity" RELATED [EC:2.7.7.3]
synonym: "pantetheine phosphate adenylyltransferase activity" RELATED [EC:2.7.7.3]
synonym: "phosphopantetheine adenylyltransferase activity" EXACT []
synonym: "PPAT activity" RELATED [EC:2.7.7.3]
xref: EC:2.7.7.3
xref: KEGG_REACTION:R03035
xref: MetaCyc:PANTEPADENYLYLTRAN-RXN
xref: Reactome:R-HSA-196754 "COASY transfers an adenylyl group from ATP to PPANT"
xref: RHEA:19801
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004596
name: peptide alpha-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-alpha-aminoacyl-[protein]." [PMID:30054468, RHEA:21028]
synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT []
synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT []
synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED []
synonym: "beta-endorphin acetyltransferase activity" NARROW []
synonym: "N(alpha)-acetyltransferase activity" RELATED []
synonym: "nalpha-acetyltransferase activity" EXACT []
synonym: "NAT activity" RELATED []
synonym: "peptide acetyltransferase activity" RELATED []
synonym: "protein N-terminal acetyltransferase activity" EXACT []
xref: EC:2.3.1.255
xref: Reactome:R-HSA-6814090 "NatC acetylates ARFFRP1"
xref: RHEA:21028
is_a: GO:0034212 ! peptide N-acetyltransferase activity

[Term]
id: GO:0004598
name: peptidylamidoglycolate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5]
synonym: "alpha-hydroxyglycine amidating dealkylase activity" RELATED [EC:4.3.2.5]
synonym: "HGAD" RELATED [EC:4.3.2.5]
synonym: "PAL" RELATED [EC:4.3.2.5]
synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" RELATED [EC:4.3.2.5]
synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" RELATED [EC:4.3.2.5]
synonym: "peptidylamidoglycolate peptidylamide-lyase activity" RELATED [EC:4.3.2.5]
synonym: "PGL" RELATED [EC:4.3.2.5]
xref: EC:4.3.2.5
xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN
xref: RHEA:20924
is_a: GO:0016842 ! amidine-lyase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004600
name: obsolete cyclophilin
namespace: molecular_function
def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "cyclophilin" EXACT []
is_obsolete: true
consider: GO:0003755
consider: GO:0016018

[Term]
id: GO:0004601
name: peroxidase activity
namespace: molecular_function
alt_id: GO:0016685
alt_id: GO:0016686
alt_id: GO:0016687
alt_id: GO:0016693
def: "Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]
subset: goslim_metagenomics
synonym: "bacterial catalase-peroxidase activity" NARROW []
synonym: "donor:hydrogen-peroxide oxidoreductase activity" RELATED []
synonym: "eosinophil peroxidase activity" NARROW []
synonym: "extensin peroxidase" NARROW []
synonym: "guaiacol peroxidase" NARROW []
synonym: "heme peroxidase" NARROW []
synonym: "horseradish peroxidase (HRP)" NARROW []
synonym: "japanese radish peroxidase" NARROW []
synonym: "lactoperoxidase activity" NARROW []
synonym: "MPO" RELATED []
synonym: "myeloperoxidase activity" NARROW []
synonym: "oxyperoxidase activity" RELATED []
synonym: "peroxidase reaction" EXACT []
synonym: "protoheme peroxidase" NARROW []
synonym: "pyrocatechol peroxidase" NARROW []
synonym: "scopoletin peroxidase" NARROW []
synonym: "secretory plant peroxidase activity" NARROW []
synonym: "thiocyanate peroxidase" NARROW []
synonym: "verdoperoxidase" NARROW []
xref: EC:1.11.1.-
xref: KEGG_REACTION:R03532
xref: Reactome:R-HSA-1222346 "AhpC reduces H2O2"
xref: Reactome:R-HSA-140359 "PGG2 is reduced to PGH2 by PTGS1"
xref: Reactome:R-HSA-209815 "Tyrosine is monoiodinated"
xref: Reactome:R-HSA-209840 "Two DITs combine to form thyroxine"
xref: Reactome:R-HSA-209925 "DIT and MIT combine to form triiodothyronine"
xref: Reactome:R-HSA-209973 "Tyrosine is diiodinated"
xref: Reactome:R-HSA-2309773 "PGG2 is reduced to PGH2 by PTGS2"
xref: Reactome:R-HSA-2559639 "Collagen type IV sulfilimine cross-linking by peroxidasin"
xref: Reactome:R-HSA-3341296 "GPX7,8 catalyze peroxidation of P4HB (PDI)"
xref: Reactome:R-HSA-350901 "Iodide is organified"
xref: Reactome:R-HSA-5631885 "PRDX1 overoxidizes"
xref: Reactome:R-HSA-6789031 "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)"
xref: Reactome:R-HSA-6789126 "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)"
xref: Reactome:R-HSA-8855490 "Lactoperoxidase (LPO) produces OSCN-"
xref: Reactome:R-HSA-8933635 "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide"
xref: Wikipedia:Peroxidase
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor

[Term]
id: GO:0004602
name: glutathione peroxidase activity
namespace: molecular_function
alt_id: GO:0016224
def: "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]
synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.9]
synonym: "GSH peroxidase activity" RELATED [EC:1.11.1.9]
synonym: "non-selenium glutathione peroxidase activity" NARROW []
synonym: "reduced glutathione peroxidase activity" RELATED [EC:1.11.1.9]
synonym: "selenium-glutathione peroxidase activity" RELATED [EC:1.11.1.9]
xref: EC:1.11.1.9
xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN
xref: Reactome:R-HSA-2161791 "15S-HpETE is reduced to 15S-HETE by GPX1/2/4"
xref: Reactome:R-HSA-2161946 "5S-HpETE is reduced to 5S-HETE by GPX1/2/4"
xref: Reactome:R-HSA-2161959 "12R-HpETE is reduced to 12R-HETE by GPX1/2/4"
xref: Reactome:R-HSA-2161999 "12S-HpETE is reduced to 12S-HETE by GPX1/2/4"
xref: Reactome:R-HSA-3323013 "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
xref: Reactome:R-HSA-3341277 "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
xref: Reactome:R-HSA-3341397 "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
xref: Reactome:R-HSA-3343700 "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
xref: Reactome:R-HSA-6799695 "GPX5,6 reduce H2O2 to H2O"
xref: Reactome:R-HSA-71676 "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O"
xref: RHEA:16833
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004603
name: phenylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28]
synonym: "noradrenalin N-methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "norepinephrine methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "norepinephrine N-methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "phenethanolamine methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "phenethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.28]
xref: EC:2.1.1.28
xref: MetaCyc:2.1.1.28-RXN
xref: Reactome:R-HSA-209903 "Noradrenaline is converted to adrenaline"
xref: RHEA:12176
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004604
name: phosphoadenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11724]
synonym: "3'-phosphoadenylylsulfate reductase activity" RELATED [EC:1.8.4.8]
synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.4.8]
synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.4.8]
synonym: "PAdoPS reductase activity" RELATED [EC:1.8.4.8]
synonym: "PAPS reductase activity" RELATED [EC:1.8.4.8]
synonym: "PAPS reductase, thioredoxin-dependent activity" RELATED [EC:1.8.4.8]
synonym: "PAPS sulfotransferase activity" RELATED [EC:1.8.4.8]
synonym: "phosphoadenosine-phosphosulfate reductase activity" RELATED [EC:1.8.4.8]
synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT []
synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" RELATED [EC:1.8.4.8]
synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" RELATED [EC:1.8.4.8]
xref: EC:1.8.4.8
xref: KEGG_REACTION:R02021
xref: MetaCyc:1.8.4.8-RXN
xref: RHEA:11724
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0004605
name: phosphatidate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41]
synonym: "CDP diglyceride pyrophosphorylase activity" RELATED [EC:2.7.7.41]
synonym: "CDP-DG" RELATED [EC:2.7.7.41]
synonym: "CDP-diacylglyceride synthetase activity" RELATED [EC:2.7.7.41]
synonym: "CDP-diacylglycerol synthase activity" EXACT []
synonym: "CDP-diglyceride diphosphorylase activity" EXACT []
synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT []
synonym: "CDP-diglyceride synthase activity" EXACT []
synonym: "CDP-diglyceride synthetase activity" RELATED [EC:2.7.7.41]
synonym: "CTP-diacylglycerol synthetase activity" RELATED [EC:2.7.7.41]
synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" RELATED [EC:2.7.7.41]
synonym: "CTP:phosphatidate cytidylyltransferase activity" RELATED [EC:2.7.7.41]
synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" RELATED [EC:2.7.7.41]
synonym: "DAG synthetase activity" RELATED [EC:2.7.7.41]
synonym: "phosphatidate cytidyltransferase activity" RELATED [EC:2.7.7.41]
synonym: "phosphatidic acid cytidylyltransferase activity" RELATED [EC:2.7.7.41]
xref: EC:2.7.7.41
xref: MetaCyc:CDPDIGLYSYN-RXN
xref: Reactome:R-HSA-1483121 "PA is converted to CDP-DAG by CDS1"
xref: Reactome:R-HSA-1483165 "PA is converted to CDP-DAG by CDS2"
xref: RHEA:16229
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004607
name: phosphatidylcholine-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43]
synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43]
synonym: "LCAT activity" RELATED [EC:2.3.1.43]
synonym: "lecithin--cholesterol acyltransferase activity" RELATED [EC:2.3.1.43]
synonym: "lecithin:cholesterol acyltransferase activity" RELATED [EC:2.3.1.43]
synonym: "phosphatidylcholine:sterol O-acyltransferase activity" RELATED [EC:2.3.1.43]
synonym: "phospholipid--cholesterol acyltransferase activity" RELATED [EC:2.3.1.43]
xref: EC:2.3.1.43
xref: MetaCyc:2.3.1.43-RXN
xref: Reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)"
xref: RHEA:21204
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004608
name: phosphatidylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17, RHEA:11164]
synonym: "lipid methyl transferase activity" RELATED [EC:2.1.1.17]
synonym: "LMTase activity" RELATED [EC:2.1.1.17]
synonym: "PEMT" RELATED [EC:2.1.1.17]
synonym: "phosphatidylethanolamine methyltransferase activity" RELATED [EC:2.1.1.17]
synonym: "phosphatidylethanolamine-N-methylase activity" RELATED [EC:2.1.1.17]
synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" RELATED [EC:2.1.1.17]
synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.17]
xref: EC:2.1.1.17
xref: KEGG_REACTION:R02056
xref: MetaCyc:2.1.1.17-RXN
xref: Reactome:R-HSA-1483174 "PE is methylated to PC by PEMT"
xref: RHEA:11164
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004609
name: phosphatidylserine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20828]
synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" RELATED [EC:4.1.1.65]
synonym: "phosphatidyl-L-serine carboxy-lyase activity" RELATED [EC:4.1.1.65]
synonym: "PS decarboxylase activity" RELATED [EC:4.1.1.65]
xref: EC:4.1.1.65
xref: KEGG_REACTION:R02055
xref: MetaCyc:PHOSPHASERDECARB-RXN
xref: Reactome:R-HSA-1483212 "PS is decarboxylated to PE by PISD"
xref: RHEA:20828
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004610
name: phosphoacetylglucosamine mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23804]
synonym: "acetylaminodeoxyglucose phosphomutase activity" RELATED [EC:5.4.2.3]
synonym: "acetylglucosamine phosphomutase activity" RELATED [EC:5.4.2.3]
synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.3]
synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.3]
synonym: "N-acetylglucosamine-phosphate mutase activity" RELATED [EC:5.4.2.3]
synonym: "phospho-N-acetylglucosamine mutase activity" RELATED [EC:5.4.2.3]
xref: EC:5.4.2.3
xref: KEGG_REACTION:R08193
xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN
xref: Reactome:R-HSA-446185 "Isomerization of GlcNAc6P to GlcNAc1P"
xref: RHEA:23804
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0004611
name: phosphoenolpyruvate carboxykinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [GOC:curators]
synonym: "PEP carboxykinase activity" RELATED []
synonym: "PEPCK activity" RELATED []
synonym: "phosphopyruvate carboxylase activity" RELATED []
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004612
name: phosphoenolpyruvate carboxykinase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate." [EC:4.1.1.49, RHEA:18617]
synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" RELATED [EC:4.1.1.49]
synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.49]
synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49]
synonym: "PEPK" RELATED [EC:4.1.1.49]
synonym: "phosphoenolpyruvate carboxylase (ATP)" RELATED [EC:4.1.1.49]
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49]
synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49]
synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" RELATED [EC:4.1.1.49]
synonym: "phosphopyruvate carboxylase (ATP)" RELATED [EC:4.1.1.49]
xref: EC:4.1.1.49
xref: KEGG_REACTION:R00341
xref: MetaCyc:PEPCARBOXYKIN-RXN
xref: RHEA:18617
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0004613
name: phosphoenolpyruvate carboxykinase (GTP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32]
synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.32]
synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" RELATED [EC:4.1.1.32]
synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT []
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32]
synonym: "phosphoenolpyruvic carboxykinase (GTP)" RELATED [EC:4.1.1.32]
synonym: "phosphoenolpyruvic carboxylase (GTP)" RELATED [EC:4.1.1.32]
synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" RELATED [EC:4.1.1.32]
synonym: "phosphopyruvate carboxylase (GTP)" RELATED [EC:4.1.1.32]
xref: EC:4.1.1.32
xref: MetaCyc:4.1.1.32-RXN
xref: Reactome:R-HSA-372819 "PCK2 phosphorylates OA to yield PEP"
xref: Reactome:R-HSA-70241 "PCK1 phosphorylates OA to yield PEP"
xref: RHEA:10388
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0004614
name: phosphoglucomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2]
synonym: "alpha-D-glucose 1,6-phosphomutase activity" RELATED [EC:5.4.2.2]
synonym: "glucose phosphomutase activity" RELATED [EC:5.4.2.2]
synonym: "phosphoglucose mutase activity" RELATED [EC:5.4.2.2]
xref: EC:5.4.2.2
xref: MetaCyc:PHOSPHOGLUCMUT-RXN
xref: Reactome:R-HSA-5609939 "Defective PGM1 does not isomerise G6P to G1P"
xref: Reactome:R-HSA-9638125 "PGM1:Mg2+ isomerises G1P to G6P"
xref: Reactome:R-HSA-9638127 "PGM1:Mg2+ isomerises G6P to G1P"
xref: RHEA:23536
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0004615
name: phosphomannomutase activity
namespace: molecular_function
alt_id: GO:0008971
def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11140]
synonym: "alpha-D-mannose 1,6-phosphomutase activity" RELATED [EC:5.4.2.8]
synonym: "D-mannose 1,6-phosphomutase activity" RELATED [EC:5.4.2.8]
synonym: "mannose phosphomutase activity" RELATED [EC:5.4.2.8]
synonym: "phosphomannose mutase activity" RELATED [EC:5.4.2.8]
xref: EC:5.4.2.8
xref: KEGG_REACTION:R01818
xref: MetaCyc:PHOSMANMUT-RXN
xref: Reactome:R-HSA-3781926 "Defective PMM2 does not isomerise Man6P to Man1P"
xref: Reactome:R-HSA-446201 "PMM1,2 isomerise Man6P to Man1P"
xref: RHEA:11140
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0004616
name: phosphogluconate dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]
synonym: "6-phospho-D-gluconate dehydrogenase activity" RELATED [EC:1.1.1.44]
synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.44]
synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.44]
synonym: "6-phosphogluconic carboxylase activity" RELATED [EC:1.1.1.44]
synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44]
synonym: "6PGD activity" RELATED [EC:1.1.1.44]
synonym: "phosphogluconic acid dehydrogenase activity" RELATED [EC:1.1.1.44]
xref: EC:1.1.1.44
xref: MetaCyc:RXN-9952
xref: Reactome:R-HSA-71299 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+"
xref: RHEA:10116
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004617
name: phosphoglycerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]
synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.95]
synonym: "3-phosphoglycerate dehydrogenase activity" RELATED [EC:1.1.1.95]
synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.95]
synonym: "3-phosphoglyceric acid dehydrogenase activity" RELATED [EC:1.1.1.95]
synonym: "3PHP reductase activity" RELATED [EC:1.1.1.95]
synonym: "alpha-KG reductase activity" RELATED [EC:1.1.1.95]
synonym: "alpha-phosphoglycerate dehydrogenase activity" RELATED [EC:1.1.1.95]
synonym: "alphaKG reductase activity" RELATED [EC:1.1.1.95]
synonym: "D- and L-HGA" RELATED [EC:1.1.1.95]
synonym: "D-3-phosphoglycerate dehydrogenase activity" RELATED [EC:1.1.1.95]
synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.95]
synonym: "glycerate 3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.95]
synonym: "glycerate-1,3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.95]
synonym: "PGDH activity" RELATED [EC:1.1.1.95]
synonym: "phosphoglycerate oxidoreductase activity" RELATED [EC:1.1.1.95]
synonym: "phosphoglyceric acid dehydrogenase activity" RELATED [EC:1.1.1.95]
synonym: "SerA" RELATED [EC:1.1.1.95]
synonym: "SerA 3PG dehydrogenase activity" RELATED [EC:1.1.1.95]
xref: EC:1.1.1.95
xref: MetaCyc:PGLYCDEHYDROG-RXN
xref: Reactome:R-HSA-977348 "PHGDH tetramer dehydrogenates 3PG"
xref: RHEA:12641
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004618
name: phosphoglycerate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+." [EC:2.7.2.3, RHEA:14801]
synonym: "3-PGK" RELATED [EC:2.7.2.3]
synonym: "3-phosphoglycerate kinase activity" RELATED [EC:2.7.2.3]
synonym: "3-phosphoglycerate phosphokinase activity" RELATED [EC:2.7.2.3]
synonym: "3-phosphoglyceric acid kinase activity" RELATED [EC:2.7.2.3]
synonym: "3-phosphoglyceric acid phosphokinase activity" RELATED [EC:2.7.2.3]
synonym: "3-phosphoglyceric kinase activity" RELATED [EC:2.7.2.3]
synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" RELATED [EC:2.7.2.3]
synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" RELATED [EC:2.7.2.3]
synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" RELATED [EC:2.7.2.3]
synonym: "glycerate 3-phosphate kinase activity" RELATED [EC:2.7.2.3]
synonym: "glycerophosphate kinase activity" RELATED [EC:2.7.2.3]
synonym: "PGK" RELATED [EC:2.7.2.3]
synonym: "phosphoglyceric acid kinase activity" RELATED [EC:2.7.2.3]
synonym: "phosphoglyceric kinase activity" RELATED [EC:2.7.2.3]
synonym: "phosphoglycerokinase activity" RELATED [EC:2.7.2.3]
xref: EC:2.7.2.3
xref: KEGG_REACTION:R01512
xref: MetaCyc:PHOSGLYPHOS-RXN
xref: Reactome:R-HSA-70486 "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG"
xref: Reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP"
xref: RHEA:14801
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0004619
name: phosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate." [RHEA:15901]
synonym: "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity" NARROW []
synonym: "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity" NARROW []
synonym: "D-phosphoglycerate 2,3-phosphomutase activity" RELATED []
synonym: "PGA mutase activity" RELATED []
synonym: "PGAM activity" RELATED []
synonym: "PGM" EXACT []
synonym: "phosphoglycerate phosphomutase activity" RELATED []
synonym: "phosphoglyceromutase activity" RELATED []
xref: KEGG_REACTION:R01516
xref: Reactome:R-HSA-71445 "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG"
xref: Reactome:R-HSA-71654 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate"
xref: RHEA:15901
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0004620
name: phospholipase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]
subset: goslim_chembl
xref: Reactome:R-HSA-6786650 "DDHD1,2 hydrolyse PA"
xref: Reactome:R-HSA-6792445 "LIPH, I hydrolyse PA to 2-acyl LPA"
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0004621
name: glycosylphosphatidylinositol phospholipase D activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50]
synonym: "glycoprotein phospholipase D activity" EXACT []
synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" RELATED [EC:3.1.4.50]
synonym: "GPI-PLD activity" RELATED [EC:3.1.4.50]
synonym: "phosphatidylinositol phospholipase D activity" RELATED [EC:3.1.4.50]
synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" RELATED [EC:3.1.4.50]
synonym: "phosphatidylinositol-specific phospholipase D activity" RELATED [EC:3.1.4.50]
xref: EC:3.1.4.50
xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN
xref: Reactome:R-HSA-8940388 "GPLD1 hydrolyses GPI-anchors from proteins"
xref: RHEA:10832
is_a: GO:0004630 ! phospholipase D activity

[Term]
id: GO:0004622
name: lysophospholipase activity
namespace: molecular_function
alt_id: GO:0045126
def: "Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]
subset: goslim_chembl
synonym: "2-lysophosphatidylcholine acylhydrolase activity" RELATED [EC:3.1.1.5]
synonym: "lecithinase B activity" RELATED [EC:3.1.1.5]
synonym: "lecitholipase activity" RELATED [EC:3.1.1.5]
synonym: "lysolecithinase activity" RELATED [EC:3.1.1.5]
synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5]
synonym: "lysophosphatidase activity" RELATED [EC:3.1.1.5]
synonym: "lysophosphatidylcholine hydrolase activity" RELATED [EC:3.1.1.5]
synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5]
synonym: "phosphatidase B" RELATED [EC:3.1.1.5]
synonym: "phospholipase B activity" RELATED [EC:3.1.1.5]
xref: EC:3.1.1.5
xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN
xref: Reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C"
xref: Reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C"
xref: Reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]"
xref: Reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C"
xref: Reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]"
xref: Reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C"
xref: Reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho"
xref: Reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho"
xref: Reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho"
xref: Reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho"
xref: RHEA:15177
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0004623
name: phospholipase A2 activity
namespace: molecular_function
alt_id: GO:0102567
alt_id: GO:0102568
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]
subset: goslim_chembl
synonym: "cytosolic phospholipase A2 activity" NARROW []
synonym: "lecithinase A activity" RELATED [EC:3.1.1.4]
synonym: "phosphatidase activity" RELATED [EC:3.1.1.4]
synonym: "phosphatidolipase activity" RELATED [EC:3.1.1.4]
synonym: "phosphatidylcholine 2-acylhydrolase activity" RELATED [EC:3.1.1.4]
synonym: "phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)" NARROW []
synonym: "phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" NARROW []
synonym: "secreted phospholipase A2 activity" NARROW []
xref: EC:3.1.1.4
xref: MetaCyc:PHOSPHOLIPASE-A2-RXN
xref: MetaCyc:RXN-15067
xref: Reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)"
xref: Reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]"
xref: Reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A"
xref: Reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)"
xref: Reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)"
xref: Reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]"
xref: Reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A"
xref: Reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)"
xref: Reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]"
xref: Reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]"
xref: Reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]"
xref: Reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]"
xref: Reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]"
xref: Reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]"
xref: Reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]"
xref: Reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]"
xref: Reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A"
xref: Reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]"
xref: Reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]"
xref: Reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]"
xref: Reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]"
xref: Reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1"
xref: Reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]"
xref: Reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]"
xref: Reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"
xref: RHEA:15801
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0004624
name: obsolete secreted phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "secreted phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0004623
consider: GO:0005576

[Term]
id: GO:0004625
name: obsolete calcium-dependent secreted phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "calcium-dependent secreted phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0005576
consider: GO:0047498

[Term]
id: GO:0004626
name: obsolete cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "cytosolic phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0004623
consider: GO:0005829

[Term]
id: GO:0004627
name: obsolete calcium-dependent cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "calcium-dependent cytosolic phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0005829
consider: GO:0047498

[Term]
id: GO:0004628
name: obsolete calcium-independent cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "calcium-independent cytosolic phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0005829
consider: GO:0047499

[Term]
id: GO:0004629
name: phospholipase C activity
namespace: molecular_function
alt_id: GO:0042298
def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [GOC:mah]
synonym: "phosphatidase C" RELATED []
xref: Reactome:R-HSA-1112666 "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate"
xref: Reactome:R-HSA-114688 "PLC-beta hydrolyses PIP2 to DAG and IP3"
xref: Reactome:R-HSA-114689 "PLC gamma 2-mediated PIP2 hydrolysis"
xref: Reactome:R-HSA-398193 "PLC beta-mediated PIP2 hydrolysis"
xref: Reactome:R-HSA-399998 "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate"
xref: Reactome:R-HSA-5362553 "NOTUM releases Hh-Np:GPC5 from the plasma membrane"
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004630
name: phospholipase D activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4]
subset: goslim_chembl
synonym: "choline phosphatase activity" RELATED [EC:3.1.4.4]
synonym: "lecithinase D activity" RELATED [EC:3.1.4.4]
synonym: "lipophosphodiesterase II activity" RELATED [EC:3.1.4.4]
synonym: "phosphatidylcholine phosphatidohydrolase activity" RELATED [EC:3.1.4.4]
xref: EC:3.1.4.4
xref: MetaCyc:PHOSCHOL-RXN
xref: Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6"
xref: Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2"
xref: Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD"
xref: RHEA:14445
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004631
name: phosphomevalonate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+." [EC:2.7.4.2, RHEA:16341]
synonym: "5-phosphomevalonate kinase activity" RELATED [EC:2.7.4.2]
synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" RELATED [EC:2.7.4.2]
synonym: "ATP:5-phosphomevalonate phosphotransferase activity" RELATED [EC:2.7.4.2]
synonym: "mevalonate phosphate kinase activity" RELATED [EC:2.7.4.2]
synonym: "mevalonate-5-phosphate kinase activity" RELATED [EC:2.7.4.2]
synonym: "mevalonic acid phosphate kinase activity" RELATED [EC:2.7.4.2]
xref: EC:2.7.4.2
xref: KEGG_REACTION:R03245
xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN
xref: Reactome:R-HSA-191422 "Mevalonate-5-phosphate is further phosphorylated"
xref: RHEA:16341
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0004632
name: phosphopantothenate--cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5]
synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" RELATED [EC:6.3.2.5]
synonym: "phosphopantothenate-cysteine ligase activity" EXACT []
synonym: "phosphopantothenoylcysteine synthetase activity" EXACT []
xref: EC:6.3.2.5
xref: MetaCyc:P-PANTOCYSLIG-RXN
xref: Reactome:R-HSA-196753 "2xPPCS ligates PPanK with Cys"
xref: RHEA:19397
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004633
name: phosphopantothenoylcysteine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16793]
synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" RELATED [EC:4.1.1.36]
synonym: "4-phosphopantotheoylcysteine decarboxylase activity" RELATED [EC:4.1.1.36]
synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.36]
synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" RELATED [EC:4.1.1.36]
synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.36]
synonym: "PPC-decarboxylase activity" RELATED [EC:4.1.1.36]
xref: EC:4.1.1.36
xref: KEGG_REACTION:R03269
xref: MetaCyc:P-PANTOCYSDECARB-RXN
xref: Reactome:R-HSA-196840 "3xPPCDC:3FMN decarboxylates PPC"
xref: RHEA:16793
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004634
name: phosphopyruvate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732]
synonym: "14-3-2-protein" RELATED [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" RELATED [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate hydro-lyase activity" RELATED [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT []
synonym: "2-phosphoglycerate dehydratase activity" RELATED [EC:4.2.1.11]
synonym: "2-phosphoglycerate enolase activity" RELATED [EC:4.2.1.11]
synonym: "2-phosphoglyceric dehydratase activity" RELATED [EC:4.2.1.11]
synonym: "enolase activity" RELATED [EC:4.2.1.11]
synonym: "gamma-enolase activity" RELATED [EC:4.2.1.11]
synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11]
synonym: "phosphoenolpyruvate hydratase activity" RELATED [EC:4.2.1.11]
xref: EC:4.2.1.11
xref: MetaCyc:2PGADEHYDRAT-RXN
xref: Reactome:R-HSA-70494 "Enolase dimers (ENO1,2,3) convert PEP to 2PG"
xref: Reactome:R-HSA-71660 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O"
xref: RHEA:10164
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004635
name: phosphoribosyl-AMP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20049]
synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" RELATED [EC:3.5.4.19]
synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" RELATED [EC:3.5.4.19]
synonym: "PRAMP-cyclohydrolase activity" RELATED [EC:3.5.4.19]
xref: EC:3.5.4.19
xref: KEGG_REACTION:R04037
xref: MetaCyc:HISTCYCLOHYD-RXN
xref: RHEA:20049
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0004636
name: phosphoribosyl-ATP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+." [EC:3.6.1.31, RHEA:22828]
synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" RELATED [EC:3.6.1.31]
synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT []
synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" RELATED [EC:3.6.1.31]
xref: EC:3.6.1.31
xref: KEGG_REACTION:R04035
xref: MetaCyc:HISTPRATPHYD-RXN
xref: RHEA:22828
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004637
name: phosphoribosylamine-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate." [EC:6.3.4.13, RHEA:17453]
synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" RELATED [EC:6.3.4.13]
synonym: "5'-phosphoribosylglycinamide synthetase activity" RELATED [EC:6.3.4.13]
synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" RELATED [EC:6.3.4.13]
synonym: "GAR" RELATED [EC:6.3.4.13]
synonym: "GAR synthetase activity" RELATED [EC:6.3.4.13]
synonym: "GARS activity" RELATED [EC:6.3.4.13]
synonym: "glycinamide ribonucleotide synthetase activity" RELATED [EC:6.3.4.13]
synonym: "glycineamide ribonucleotide synthetase activity" RELATED [EC:6.3.4.13]
synonym: "phosphoribosylglycinamide synthetase activity" RELATED [EC:6.3.4.13]
synonym: "phosphoribosylglycineamide synthetase activity" RELATED [EC:6.3.4.13]
xref: EC:6.3.4.13
xref: KEGG_REACTION:R04144
xref: MetaCyc:GLYRIBONUCSYN-RXN
xref: Reactome:R-HSA-73814 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi"
xref: RHEA:17453
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004638
name: phosphoribosylaminoimidazole carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2." [EC:4.1.1.21, RHEA:10792]
synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" RELATED [EC:4.1.1.21]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" RELATED [EC:4.1.1.21]
synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" RELATED [EC:4.1.1.21]
synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" RELATED [EC:4.1.1.21]
synonym: "ADE2" RELATED [EC:4.1.1.21]
synonym: "AIR carboxylase activity" RELATED [EC:4.1.1.21]
synonym: "class II PurE" RELATED [EC:4.1.1.21]
xref: EC:4.1.1.21
xref: KEGG_REACTION:R04209
xref: MetaCyc:AIRCARBOXY-RXN
xref: Reactome:R-HSA-73806 "AIR + CO2 => CAIR"
xref: RHEA:10792
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004639
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate." [EC:6.3.2.6, RHEA:22628]
synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.2.6]
synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" RELATED [EC:6.3.2.6]
synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.2.6]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" RELATED [EC:6.3.2.6]
synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" RELATED [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" RELATED [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" RELATED [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" RELATED [EC:6.3.2.6]
synonym: "PurC" RELATED [EC:6.3.2.6]
synonym: "SAICAR synthase activity" RELATED [EC:6.3.2.6]
synonym: "SAICAR synthetase activity" RELATED [EC:6.3.2.6]
synonym: "SAICARs activity" RELATED [EC:6.3.2.6]
xref: EC:6.3.2.6
xref: KEGG_REACTION:R04591
xref: MetaCyc:SAICARSYN-RXN
xref: Reactome:R-HSA-73805 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi"
xref: RHEA:22628
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004640
name: phosphoribosylanthranilate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [RHEA:21540]
synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24]
synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" RELATED [EC:5.3.1.24]
synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.24]
synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" RELATED [EC:5.3.1.24]
synonym: "PRA isomerase activity" RELATED [EC:5.3.1.24]
synonym: "PRAI activity" RELATED [EC:5.3.1.24]
xref: EC:5.3.1.24
xref: KEGG_REACTION:R03509
xref: MetaCyc:PRAISOM-RXN
xref: RHEA:21540
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004641
name: phosphoribosylformylglycinamidine cyclo-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate." [EC:6.3.3.1, RHEA:23032]
synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.1]
synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.1]
synonym: "5'-aminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.3.1]
synonym: "AIR synthase activity" RELATED [EC:6.3.3.1]
synonym: "AIR synthetase activity" RELATED [EC:6.3.3.1]
synonym: "AIRS activity" RELATED [EC:6.3.3.1]
synonym: "phosphoribosyl-aminoimidazole synthetase activity" RELATED [EC:6.3.3.1]
synonym: "phosphoribosylaminoimidazole synthetase activity" RELATED [EC:6.3.3.1]
xref: EC:6.3.3.1
xref: KEGG_REACTION:R04208
xref: MetaCyc:AIRS-RXN
xref: Reactome:R-HSA-73810 "FGAM + ATP => AIR + ADP + Pi"
xref: RHEA:23032
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0004642
name: phosphoribosylformylglycinamidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate." [EC:6.3.5.3, RHEA:17129]
synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.3]
synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.3]
synonym: "FGAM synthase activity" RELATED [EC:6.3.5.3]
synonym: "FGAM synthetase activity" RELATED [EC:6.3.5.3]
synonym: "FGAR amidotransferase activity" RELATED [EC:6.3.5.3]
synonym: "FGARAT activity" RELATED [EC:6.3.5.3]
synonym: "formylglycinamide ribonucloetide amidotransferase activity" RELATED [EC:6.3.5.3]
synonym: "formylglycinamide ribotide amidotransferase activity" RELATED [EC:6.3.5.3]
synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.3]
synonym: "phosphoribosylformylglycinamidine synthetase activity" RELATED [EC:6.3.5.3]
synonym: "phosphoribosylformylglycineamidine synthetase activity" RELATED [EC:6.3.5.3]
xref: EC:6.3.5.3
xref: KEGG_REACTION:R04463
xref: MetaCyc:FGAMSYN-RXN
xref: Reactome:R-HSA-73812 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi"
xref: RHEA:17129
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004643
name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3]
synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" RELATED [EC:2.1.2.3]
synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" RELATED [EC:2.1.2.3]
synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" RELATED [EC:2.1.2.3]
synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" RELATED [EC:2.1.2.3]
synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.3]
synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" RELATED [EC:2.1.2.3]
synonym: "AICAR formyltransferase activity" RELATED [EC:2.1.2.3]
synonym: "AICAR transformylase activity" RELATED [EC:2.1.2.3]
synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.3]
xref: EC:2.1.2.3
xref: MetaCyc:AICARTRANSFORM-RXN
xref: Reactome:R-HSA-73798 "AICAR + 10-Formyl-THF => FAICAR + THF"
xref: RHEA:22192
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004644
name: phosphoribosylglycinamide formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2]
synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" RELATED [EC:2.1.2.2]
synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" RELATED [EC:2.1.2.2]
synonym: "5'-phosphoribosylglycinamide transformylase activity" RELATED [EC:2.1.2.2]
synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.2]
synonym: "GAR formyltransferase activity" RELATED [EC:2.1.2.2]
synonym: "GAR TFase activity" RELATED [EC:2.1.2.2]
synonym: "GAR transformylase activity" RELATED [EC:2.1.2.2]
synonym: "GART activity" RELATED [EC:2.1.2.2]
synonym: "glycinamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.2]
xref: EC:2.1.2.2
xref: MetaCyc:GART-RXN
xref: Reactome:R-HSA-73813 "GAR + 10-Formyl-THF => FGAR + THF"
xref: RHEA:15053
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004645
name: 1,4-alpha-oligoglucan phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [RHEA:41732]
synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.1]
synonym: "1,4-alpha-glucan phosphorylase activity" RELATED [EC:2.4.1.1]
synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1]
synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1]
synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1]
synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1]
synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1]
synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1]
synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1]
synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1]
synonym: "myophosphorylase" NARROW [EC:2.4.1.1]
synonym: "polyphosphorylase activity" RELATED [EC:2.4.1.1]
synonym: "potato phosphorylase" NARROW [EC:2.4.1.1]
synonym: "starch phosphorylase" NARROW [EC:2.4.1.1]
xref: EC:2.4.1.1
xref: MetaCyc:RXN0-5184
xref: RHEA:41732
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0004648
name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
alt_id: GO:0004646
def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52]
synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.52]
synonym: "3-phosphoserine aminotransferase activity" RELATED [EC:2.6.1.52]
synonym: "3PHP transaminase activity" RELATED [EC:2.6.1.52]
synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" RELATED [EC:2.6.1.52]
synonym: "L-phosphoserine aminotransferase activity" RELATED [EC:2.6.1.52]
synonym: "PdxC" RELATED [EC:2.6.1.52]
synonym: "phosphohydroxypyruvate transaminase activity" RELATED [EC:2.6.1.52]
synonym: "phosphohydroxypyruvic--glutamic transaminase activity" RELATED [EC:2.6.1.52]
synonym: "phosphoserine aminotransferase activity" BROAD []
synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52]
synonym: "PSAT activity" RELATED [EC:2.6.1.52]
synonym: "SerC" RELATED [EC:2.6.1.52]
xref: EC:2.6.1.52
xref: MetaCyc:PSERTRANSAM-RXN
xref: Reactome:R-HSA-977333 "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA"
xref: RHEA:14329
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004649
name: poly(ADP-ribose) glycohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]
xref: EC:3.2.1.143
xref: MetaCyc:3.2.1.143-RXN
xref: Reactome:R-HSA-5651828 "PARG dePARylates PARP1,PARP2"
xref: Reactome:R-HSA-8952903 "ADPRHL2 hydrolyses poly(ADP-ribose)"
xref: RHEA:52216
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004650
name: polygalacturonase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15]
synonym: "endo-D-galacturonase activity" EXACT []
synonym: "endo-polygalacturonase activity" EXACT []
synonym: "endogalacturonase activity" EXACT []
synonym: "endopolygalacturonase activity" EXACT []
synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15]
synonym: "pectin hydrolase activity" RELATED [EC:3.2.1.15]
synonym: "pectin polygalacturonase activity" RELATED [EC:3.2.1.15]
synonym: "pectinase activity" NARROW [EC:3.2.1.15]
synonym: "pectolase activity" RELATED [EC:3.2.1.15]
synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT []
synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT []
xref: EC:3.2.1.15
xref: MetaCyc:RXN-2103
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004651
name: polynucleotide 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate." [EC:3.1.3.33]
synonym: "5'-polynucleotidase activity" RELATED [EC:3.1.3.33]
synonym: "polynucleotide 5'-phosphohydrolase activity" RELATED [EC:3.1.3.33]
synonym: "polynucleotide 5'-triphosphatase activity" RELATED [EC:3.1.3.33]
xref: EC:3.1.3.33
xref: MetaCyc:RXN-21861
xref: Reactome:R-HSA-77078 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004652
name: obsolete polynucleotide adenylyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]
comment: This term was obsoleted because it represents the same activity as RNA adenylyltransferase activity ; GO:1990817.
synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" RELATED [EC:2.7.7.19]
synonym: "AMP polynucleotidylexotransferase activity" RELATED [EC:2.7.7.19]
synonym: "ATP-polynucleotide adenylyltransferase activity" RELATED [EC:2.7.7.19]
synonym: "ATP:polynucleotide adenylyltransferase activity" RELATED [EC:2.7.7.19]
synonym: "ATP:polynucleotidylexotransferase activity" RELATED [EC:2.7.7.19]
synonym: "NTP polymerase activity" RELATED [EC:2.7.7.19]
synonym: "poly(A) hydrolase activity" RELATED [EC:2.7.7.19]
synonym: "poly(A) polymerase activity" RELATED [EC:2.7.7.19]
synonym: "poly(A) synthetase activity" RELATED [EC:2.7.7.19]
synonym: "poly-A polymerase activity" RELATED [EC:2.7.7.19]
synonym: "polyadenylate nucleotidyltransferase activity" RELATED [EC:2.7.7.19]
synonym: "polyadenylate polymerase activity" RELATED [EC:2.7.7.19]
synonym: "polyadenylate synthetase activity" RELATED [EC:2.7.7.19]
synonym: "polyadenylic acid polymerase activity" RELATED [EC:2.7.7.19]
synonym: "polyadenylic polymerase activity" RELATED [EC:2.7.7.19]
synonym: "RNA adenylating enzyme activity" RELATED [EC:2.7.7.19]
synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19]
synonym: "terminal riboadenylate transferase activity" RELATED [EC:2.7.7.19]
is_obsolete: true
replaced_by: GO:1990817

[Term]
id: GO:0004653
name: polypeptide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
synonym: "glycoprotein acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "polypeptide-N-acetylgalactosamine transferase activity" RELATED [EC:2.4.1.41]
synonym: "protein-UDP acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" RELATED [EC:2.4.1.41]
synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41]
xref: EC:2.4.1.41
xref: MetaCyc:2.4.1.41-RXN
xref: Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins"
xref: Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins"
xref: Reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23"
xref: Reactome:R-HSA-913675 "GALNTs transfer GalNAc to Mucins to form Tn antigens"
xref: Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a"
xref: Reactome:R-HSA-9694438 "GalNAc is transferred onto 3a"
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004654
name: polyribonucleotide nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate." [EC:2.7.7.8]
synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" RELATED [EC:2.7.7.8]
synonym: "polynucleotide phosphorylase activity" RELATED [EC:2.7.7.8]
synonym: "polyribonucleotide phosphorylase activity" RELATED [EC:2.7.7.8]
synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.8]
xref: EC:2.7.7.8
xref: MetaCyc:2.7.7.8-RXN
xref: RHEA:22096
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0004655
name: porphobilinogen synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen." [EC:4.2.1.24, RHEA:24064]
synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" RELATED [EC:4.2.1.24]
synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" RELATED [EC:4.2.1.24]
synonym: "5-levulinic acid dehydratase activity" RELATED [EC:4.2.1.24]
synonym: "aminolevulinate dehydratase activity" EXACT []
synonym: "aminolevulinic dehydratase activity" RELATED [EC:4.2.1.24]
synonym: "delta-aminolevulinate dehydratase activity" RELATED [EC:4.2.1.24]
synonym: "delta-aminolevulinic acid dehydrase activity" RELATED [EC:4.2.1.24]
synonym: "delta-aminolevulinic acid dehydratase activity" EXACT []
synonym: "delta-aminolevulinic dehydratase activity" RELATED [EC:4.2.1.24]
xref: EC:4.2.1.24
xref: KEGG_REACTION:R00036
xref: MetaCyc:PORPHOBILSYNTH-RXN
xref: Reactome:R-HSA-189439 "ALAD condenses 2 dALAs to form PBG"
xref: RHEA:24064
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004656
name: procollagen-proline 4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2]
synonym: "collagen proline hydroxylase activity" RELATED [EC:1.14.11.2]
synonym: "hydroxylase, collagen proline activity" RELATED [EC:1.14.11.2]
synonym: "peptidyl proline hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" RELATED [EC:1.14.11.2]
synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT []
synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "proline protocollagen hydroxylase activity" RELATED [EC:1.14.11.2]
synonym: "proline, 2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.2]
synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" BROAD [EC:1.14.11.2]
synonym: "prolylprotocollagen dioxygenase activity" RELATED [EC:1.14.11.2]
synonym: "prolylprotocollagen hydroxylase activity" RELATED [EC:1.14.11.2]
synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "protocollagen proline 4-hydroxylase activity" RELATED [EC:1.14.11.2]
synonym: "protocollagen proline dioxygenase activity" RELATED [EC:1.14.11.2]
synonym: "protocollagen proline hydroxylase activity" RELATED [EC:1.14.11.2]
synonym: "protocollagen prolyl hydroxylase activity" RELATED [EC:1.14.11.2]
xref: EC:1.14.11.2
xref: KEGG_REACTION:R03219
xref: MetaCyc:1.14.11.2-RXN
xref: Reactome:R-HSA-1650808 "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines"
xref: RHEA:18945
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity

[Term]
id: GO:0004657
name: proline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [RHEA:23784]
synonym: "L-proline dehydrogenase activity" RELATED []
synonym: "proline oxidase activity" EXACT []
xref: EC:1.5.5.2
xref: MetaCyc:RXN-14903
xref: Reactome:R-HSA-6784224 "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate"
xref: Reactome:R-HSA-70670 "PRODH oxidises L-Pro to 1PYR-5COOH"
xref: Reactome:R-HSA-8955817 "PRODH2 oxidises HPRO to 1PYR-5COOH"
xref: RHEA:23784
is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0004658
name: propionyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3]
synonym: "PCCase activity" RELATED [EC:6.4.1.3]
synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.3]
synonym: "propionyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.3]
xref: EC:6.4.1.3
xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN
xref: Reactome:R-HSA-71031 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate"
xref: RHEA:23720
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0004659
name: prenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]
xref: Reactome:R-HSA-6806674 "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004660
name: protein farnesyltransferase activity
namespace: molecular_function
alt_id: GO:0018223
def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375]
comment: The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.
synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58]
synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" RELATED [EC:2.5.1.58]
synonym: "FTase activity" RELATED [EC:2.5.1.58]
synonym: "protein-cysteine farnesyltransferase activity" EXACT []
xref: EC:2.5.1.58
xref: MetaCyc:RXN-17573
xref: Reactome:R-HSA-2530501 "FNTA:FNTB transfers FARN to GNGT1"
xref: Reactome:R-HSA-9647978 "pro-RAS proteins are farnesylated"
xref: RHEA:13345
is_a: GO:0008318 ! protein prenyltransferase activity

[Term]
id: GO:0004661
name: protein geranylgeranyltransferase activity
namespace: molecular_function
alt_id: GO:0018224
def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375]
synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT []
xref: RHEA:21240
is_a: GO:0008318 ! protein prenyltransferase activity

[Term]
id: GO:0004662
name: CAAX-protein geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]
synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
synonym: "geranylgeranyltransferase type I activity" EXACT []
synonym: "GGTase-I activity" EXACT []
synonym: "GGTaseI activity" EXACT []
synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59]
synonym: "type I protein geranyl-geranyltransferase activity" RELATED [EC:2.5.1.59]
xref: EC:2.5.1.59
xref: MetaCyc:RXN-3701
is_a: GO:0004661 ! protein geranylgeranyltransferase activity

[Term]
id: GO:0004663
name: Rab geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]
synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
synonym: "GGTase-II activity" EXACT []
synonym: "GGTaseII activity" EXACT []
synonym: "protein geranylgeranyltransferase type II activity" EXACT []
synonym: "Rab-protein geranylgeranyltransferase activity" EXACT []
synonym: "RabGGTase activity" EXACT []
synonym: "type II protein geranyl-geranyltransferase activity" RELATED [EC:2.5.1.60]
xref: EC:2.5.1.60
is_a: GO:0004661 ! protein geranylgeranyltransferase activity

[Term]
id: GO:0004664
name: prephenate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51]
synonym: "prephenate hydro-lyase (decarboxylating)" RELATED [EC:4.2.1.51]
synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" RELATED [EC:4.2.1.51]
xref: EC:4.2.1.51
xref: MetaCyc:PREPHENATEDEHYDRAT-RXN
xref: RHEA:21648
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004665
name: prephenate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH." [EC:1.3.1.13, RHEA:21640]
synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.3.1.13]
synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.13]
xref: EC:1.3.1.13
xref: KEGG_REACTION:R01730
xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21640
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004666
name: prostaglandin-endoperoxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2." [RHEA:23728]
synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" RELATED [EC:1.14.99.1]
synonym: "(PG)H synthase activity" RELATED [EC:1.14.99.1]
synonym: "fatty acid cyclooxygenase activity" RELATED [EC:1.14.99.1]
synonym: "PG synthetase activity" RELATED [EC:1.14.99.1]
synonym: "prostaglandin endoperoxide synthetase activity" RELATED [EC:1.14.99.1]
synonym: "prostaglandin G/H synthase activity" RELATED [EC:1.14.99.1]
synonym: "prostaglandin synthase activity" RELATED [EC:1.14.99.1]
synonym: "prostaglandin synthetase activity" RELATED [EC:1.14.99.1]
xref: EC:1.14.99.1
xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
xref: Reactome:R-HSA-140355 "Arachidonate is oxidised to PGG2 by PTGS1"
xref: Reactome:R-HSA-2309787 "Arachidonate is oxidised to PGG2 by PTGS2"
xref: RHEA:23728
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004667
name: prostaglandin-D synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10600]
synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" RELATED [EC:5.3.99.2]
synonym: "PGD2 synthase activity" RELATED [EC:5.3.99.2]
synonym: "PGH-PGD isomerase activity" RELATED [EC:5.3.99.2]
synonym: "prostaglandin D2 synthase activity" RELATED [EC:5.3.99.2]
synonym: "prostaglandin-H2 D-isomerase activity" RELATED [EC:5.3.99.2]
synonym: "prostaglandin-R-prostaglandin D isomerase activity" RELATED [EC:5.3.99.2]
xref: EC:5.3.99.2
xref: KEGG_REACTION:R02266
xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN
xref: Reactome:R-HSA-2161620 "PGH2 is isomerised to PGD2 by PTGDS"
xref: Reactome:R-HSA-2161701 "PGH2 is isomerised to PGD2 by HPGDS"
xref: RHEA:10600
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0004668
name: protein-arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent." [PMID:27393304]
synonym: "peptidylarginine deiminase activity" RELATED [EC:3.5.3.15]
synonym: "protein-L-arginine iminohydrolase activity" RELATED [EC:3.5.3.15]
xref: EC:3.5.3.15
xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN
xref: Reactome:R-HSA-1183128 "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins"
xref: Reactome:R-HSA-3247569 "PADI4 deiminates Histones"
xref: RHEA:18089
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004671
name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0018225
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100]
synonym: "farnesyl cysteine C-terminal methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "farnesyl-protein carboxymethyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "farnesylated protein C-terminal O-methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "isoprenylated protein methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylated protein carboxyl methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylated protein methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylcysteine carboxymethyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylcysteine methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "protein-S-isoprenylcysteine O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "S-farnesylcysteine methyltransferase activity" RELATED [EC:2.1.1.100]
xref: EC:2.1.1.100
xref: KEGG_REACTION:R04496
xref: MetaCyc:2.1.1.100-RXN
xref: Reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins"
xref: Reactome:R-HSA-9647977 "ICMT methylates S-Farn RAS proteins"
xref: RHEA:21672
is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004672
name: protein kinase activity
namespace: molecular_function
alt_id: GO:0050222
def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]
comment: Note that triphosphate is used as a phosphate donor by at least one kinase.
subset: goslim_candida
synonym: "protamine kinase activity" NARROW []
xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a"
xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino"
xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4"
xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation"
xref: Reactome:R-HSA-9732753 "JAK1-activated RAF1 phosphorylates MAPKs"
xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation"
xref: Reactome:R-HSA-9833820 "PKR dimer autophosphorylates"
xref: Reactome:R-HSA-9835885 "p-PKR dimer phosphorylates eIF2-alpha"
xref: Reactome:R-HSA-9836159 "p-PKR dimer phosphorylates DHX9"
xref: Reactome:R-HSA-9836184 "p-PKR dimer phosphorylates CDK1"
xref: Reactome:R-HSA-9836322 "p-PKR dimer phosphorylates MKK6"
xref: Reactome:R-HSA-9836362 "p-PKR dimer phosphorylates TP53 tetramer"
xref: Reactome:R-HSA-9836383 "p-PKR dimer phosphorylates ILF3:ILF2"
xref: Reactome:R-HSA-9836404 "p-PKR dimer phosphorylates MAPT"
xref: Reactome:R-HSA-9836435 "p-PKR dimer phosphorylates SNCA"
xref: Reactome:R-HSA-9836449 "p-PKR dimer phosphorylates HIV tat"
xref: Reactome:R-HSA-9836515 "p-PKR dimer phosphorylates PTPN2"
xref: Reactome:R-HSA-9836617 "p-PKR dimer phosphorylates SPHK1"
xref: Reactome:R-HSA-9836664 "p-PKR dimer phosphorylates PPP2R5A"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004673
name: protein histidine kinase activity
namespace: molecular_function
alt_id: GO:0008896
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah]
synonym: "ATP:protein-L-histidine N-phosphotransferase activity" RELATED [EC:2.7.13.3]
synonym: "histidine kinase activity" EXACT []
synonym: "histidine protein kinase activity" RELATED [EC:2.7.13.3]
synonym: "protein kinase (histidine)" RELATED [EC:2.7.13.3]
synonym: "protein-histidine kinase activity" EXACT []
xref: EC:2.7.13.3
xref: MetaCyc:2.7.13.3-RXN
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0004674
name: protein serine/threonine kinase activity
namespace: molecular_function
alt_id: GO:0004695
alt_id: GO:0004696
alt_id: GO:0004700
alt_id: GO:0106311
def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925]
synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "protein serine-threonine kinase activity" RELATED [EC:2.7.11.1]
synonym: "protein threonine kinase activity" NARROW []
synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine(threonine) protein kinase activity" RELATED [EC:2.7.11.1]
synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine/threonine protein kinase activity" RELATED [EC:2.7.11.1]
synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1]
xref: EC:2.7.11.-
xref: MetaCyc:PROTEIN-KINASE-RXN
xref: Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2"
xref: Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1"
xref: Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2"
xref: Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3"
xref: Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1"
xref: Reactome:R-HSA-111919 "PKA phosphorylates CREB1"
xref: Reactome:R-HSA-111970 "PKC phosphorylates GRK2"
xref: Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1"
xref: Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex"
xref: Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1"
xref: Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB"
xref: Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta"
xref: Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin"
xref: Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL"
xref: Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor"
xref: Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL"
xref: Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT"
xref: Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A"
xref: Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8"
xref: Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK"
xref: Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)"
xref: Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A"
xref: Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1"
xref: Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2"
xref: Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor"
xref: Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation"
xref: Reactome:R-HSA-156678 "Activation of Cdc25C"
xref: Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC"
xref: Reactome:R-HSA-156699 "Inactivation of Wee1 kinase"
xref: Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation"
xref: Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A"
xref: Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B"
xref: Reactome:R-HSA-162657 "Inactivation of Myt1 kinase"
xref: Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1"
xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex"
xref: Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP"
xref: Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP"
xref: Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres"
xref: Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer"
xref: Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB"
xref: Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB"
xref: Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1"
xref: Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)"
xref: Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1"
xref: Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1"
xref: Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1"
xref: Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1"
xref: Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal"
xref: Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex"
xref: Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP"
xref: Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps"
xref: Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex"
xref: Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD"
xref: Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2"
xref: Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor"
xref: Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex"
xref: Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes"
xref: Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes"
xref: Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes"
xref: Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2"
xref: Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain"
xref: Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor"
xref: Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1"
xref: Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1"
xref: Reactome:R-HSA-176116 "Recruitment and activation of Chk1"
xref: Reactome:R-HSA-176298 "Activation of claspin"
xref: Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3"
xref: Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2"
xref: Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2"
xref: Reactome:R-HSA-193647 "IRAK is activated"
xref: Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate"
xref: Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex"
xref: Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3"
xref: Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3"
xref: Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3"
xref: Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha"
xref: Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308"
xref: Reactome:R-HSA-198347 "AKT phosphorylates BAD"
xref: Reactome:R-HSA-198371 "AKT phosphorylates GSK3"
xref: Reactome:R-HSA-198599 "AKT phosphorylates MDM2"
xref: Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it"
xref: Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha"
xref: Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1"
xref: Reactome:R-HSA-198621 "AKT phosphorylates caspase-9"
xref: Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473"
xref: Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1"
xref: Reactome:R-HSA-198731 "ERK1/2 activates ELK1"
xref: Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3"
xref: Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1"
xref: Reactome:R-HSA-199298 "AKT phosphorylates CREB1"
xref: Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors"
xref: Reactome:R-HSA-199839 "AKT can phosphorylate RSK"
xref: Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)"
xref: Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 119"
xref: Reactome:R-HSA-199910 "MSK1 activates ATF1"
xref: Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133"
xref: Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2"
xref: Reactome:R-HSA-199935 "MSK1 activates CREB"
xref: Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)"
xref: Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation"
xref: Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta"
xref: Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI"
xref: Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL"
xref: Reactome:R-HSA-202111 "AKT1 phosphorylates eNOS"
xref: Reactome:R-HSA-202222 "Phosphorylation of PKC theta"
xref: Reactome:R-HSA-202437 "Phosphorylation of CARMA1"
xref: Reactome:R-HSA-202459 "Phosphorylation of Bcl10"
xref: Reactome:R-HSA-202500 "Activation of IKK complex"
xref: Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex"
xref: Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB"
xref: Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4"
xref: Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)"
xref: Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2"
xref: Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)"
xref: Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3"
xref: Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1"
xref: Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)"
xref: Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)"
xref: Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2"
xref: Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N"
xref: Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N"
xref: Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N"
xref: Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N"
xref: Reactome:R-HSA-2029454 "Autophosphorylation of PAK1"
xref: Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1"
xref: Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI"
xref: Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1"
xref: Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase"
xref: Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A"
xref: Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at  Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197"
xref: Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop"
xref: Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19"
xref: Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9"
xref: Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1"
xref: Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex"
xref: Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant"
xref: Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex"
xref: Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1"
xref: Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD"
xref: Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3"
xref: Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1"
xref: Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)"
xref: Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2"
xref: Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it"
xref: Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9"
xref: Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)"
xref: Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors"
xref: Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1"
xref: Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK"
xref: Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)"
xref: Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2"
xref: Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA"
xref: Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms"
xref: Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin"
xref: Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits"
xref: Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN"
xref: Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation"
xref: Reactome:R-HSA-2730856 "Autophosphorylation of PAK"
xref: Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1"
xref: Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1"
xref: Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1"
xref: Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6"
xref: Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9"
xref: Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7"
xref: Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98"
xref: Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1"
xref: Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1"
xref: Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA"
xref: Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2"
xref: Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF"
xref: Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1"
xref: Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53"
xref: Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6"
xref: Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1"
xref: Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)"
xref: Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53"
xref: Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5"
xref: Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407"
xref: Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3"
xref: Reactome:R-HSA-3371531 "Constitutive phosphorylation  by pERK1/2"
xref: Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART"
xref: Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2"
xref: Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387  by ATM"
xref: Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM"
xref: Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk"
xref: Reactome:R-HSA-3769394 "AKT phosphorylates CBY1"
xref: Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)"
xref: Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL"
xref: Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp"
xref: Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates"
xref: Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK"
xref: Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321"
xref: Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB"
xref: Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL"
xref: Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot"
xref: Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II"
xref: Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2"
xref: Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it"
xref: Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs"
xref: Reactome:R-HSA-3928620 "PAK1 autophosphorylates"
xref: Reactome:R-HSA-3928625 "PAKs autophosphorylate"
xref: Reactome:R-HSA-3928640 "PAKs phosphorylate MLC"
xref: Reactome:R-HSA-399939 "Autophosphorylation of PAK"
xref: Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5"
xref: Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1"
xref: Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta"
xref: Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK"
xref: Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS"
xref: Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins"
xref: Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1"
xref: Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK"
xref: Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK"
xref: Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK"
xref: Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1"
xref: Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha"
xref: Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2"
xref: Reactome:R-HSA-429714 "CSNK1G2 phosphorylates p-CERT1-2"
xref: Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding"
xref: Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation"
xref: Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2"
xref: Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT"
xref: Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF"
xref: Reactome:R-HSA-4411402 "Activation of NLK"
xref: Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)"
xref: Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs"
xref: Reactome:R-HSA-442832 "PAK phosphorylates cortactin"
xref: Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP"
xref: Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1"
xref: Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates"
xref: Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK"
xref: Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38"
xref: Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3"
xref: Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2"
xref: Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7"
xref: Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6"
xref: Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)"
xref: Reactome:R-HSA-450474 "MK2 phosphorylates BRF1"
xref: Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1"
xref: Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP"
xref: Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2"
xref: Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP"
xref: Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A"
xref: Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD"
xref: Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1"
xref: Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation"
xref: Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation"
xref: Reactome:R-HSA-5213464 "RIPK1 is phosphorylated"
xref: Reactome:R-HSA-5213466 "RIPK3 is phosphorylated"
xref: Reactome:R-HSA-5218814 "PAK2 autophorylates"
xref: Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC"
xref: Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732"
xref: Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21"
xref: Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL"
xref: Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27"
xref: Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB"
xref: Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex"
xref: Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5"
xref: Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates"
xref: Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin"
xref: Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418"
xref: Reactome:R-HSA-5578777 "DMPK phosphorylates PLN"
xref: Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer"
xref: Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB"
xref: Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates"
xref: Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta"
xref: Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2"
xref: Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3"
xref: Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2"
xref: Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3"
xref: Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit"
xref: Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338"
xref: Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3"
xref: Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer"
xref: Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer"
xref: Reactome:R-HSA-5635841 "GLI proteins are phosphorylated"
xref: Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI"
xref: Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)"
xref: Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores"
xref: Reactome:R-HSA-5668545 "NIK autophosphorylates on T559"
xref: Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)"
xref: Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase"
xref: Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK"
xref: Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA"
xref: Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A"
xref: Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs"
xref: Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated"
xref: Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1"
xref: Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1"
xref: Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1"
xref: Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs"
xref: Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer"
xref: Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1"
xref: Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1"
xref: Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF"
xref: Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1"
xref: Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1"
xref: Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM"
xref: Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer"
xref: Reactome:R-HSA-5682598 "ATM phosphorylates HERC2"
xref: Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1"
xref: Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs"
xref: Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates"
xref: Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1"
xref: Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4"
xref: Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8"
xref: Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8"
xref: Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs"
xref: Reactome:R-HSA-5685156 "ATR phosphorylates RPA2"
xref: Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51"
xref: Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2"
xref: Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1"
xref: Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C"
xref: Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4"
xref: Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3"
xref: Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5"
xref: Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3"
xref: Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1"
xref: Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs"
xref: Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1"
xref: Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN"
xref: Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs"
xref: Reactome:R-HSA-5692779 "p-T182 MAPKAPK5 phosphorylates FOXO1"
xref: Reactome:R-HSA-5693536 "ATM phosphorylates MDC1"
xref: Reactome:R-HSA-5693540 "MRN activates ATM"
xref: Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs"
xref: Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM"
xref: Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates"
xref: Reactome:R-HSA-5693598 "ATM phosphorylates NBN"
xref: Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15"
xref: Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23"
xref: Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA"
xref: Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1"
xref: Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2"
xref: Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1"
xref: Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2"
xref: Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53"
xref: Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420"
xref: Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53"
xref: Reactome:R-HSA-6799332 "ATR phosphorylates TP53"
xref: Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53"
xref: Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1"
xref: Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ"
xref: Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1"
xref: Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks"
xref: Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks"
xref: Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks"
xref: Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks"
xref: Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers"
xref: Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks"
xref: Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C"
xref: Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5"
xref: Reactome:R-HSA-6804276 "ATM phosphorylates TTC5"
xref: Reactome:R-HSA-6804955 "ATM phosphorylates MDM2"
xref: Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53"
xref: Reactome:R-HSA-6805103 "AURKA phosphorylates TP53"
xref: Reactome:R-HSA-6805126 "AURKB phosphorylates TP53"
xref: Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53"
xref: Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53"
xref: Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53"
xref: Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53"
xref: Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A"
xref: Reactome:R-HSA-6805785 "AKT phosphorylates PHF20"
xref: Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter"
xref: Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A"
xref: Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL"
xref: Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1"
xref: Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2"
xref: Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53"
xref: Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM"
xref: Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1"
xref: Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1"
xref: Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2"
xref: Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta"
xref: Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD"
xref: Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN"
xref: Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends"
xref: Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1"
xref: Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation"
xref: Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1"
xref: Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer"
xref: Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156"
xref: Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B"
xref: Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C"
xref: Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A"
xref: Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23"
xref: Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3"
xref: Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2"
xref: Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1"
xref: Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A"
xref: Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1"
xref: Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2"
xref: Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN"
xref: Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3"
xref: Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10"
xref: Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3"
xref: Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B"
xref: Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300"
xref: Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1"
xref: Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2"
xref: Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling"
xref: Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2"
xref: Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1"
xref: Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6"
xref: Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1"
xref: Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2"
xref: Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17"
xref: Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1"
xref: Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates"
xref: Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6"
xref: Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2"
xref: Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2"
xref: Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2"
xref: Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD"
xref: Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex"
xref: Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2"
xref: Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423"
xref: Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3"
xref: Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2"
xref: Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions"
xref: Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2"
xref: Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7"
xref: Reactome:R-HSA-933525 "Phosphorylation and release of IRF7"
xref: Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1"
xref: Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex"
xref: Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP"
xref: Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex"
xref: Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4"
xref: Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF"
xref: Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF"
xref: Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF"
xref: Reactome:R-HSA-9612501 "SGK phosphorylates CREB1"
xref: Reactome:R-HSA-9612509 "SGK phosphorylates SRF"
xref: Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates"
xref: Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs"
xref: Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT"
xref: Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs"
xref: Reactome:R-HSA-9620004 "RSKs autophosphorylate"
xref: Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR"
xref: Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345"
xref: Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T412"
xref: Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen"
xref: Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1"
xref: Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates"
xref: Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2"
xref: Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA"
xref: Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4"
xref: Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates"
xref: Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)"
xref: Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs"
xref: Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181"
xref: Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants"
xref: Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer"
xref: Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17"
xref: Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL"
xref: Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein"
xref: Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3"
xref: Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172"
xref: Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE"
xref: Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner"
xref: Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein"
xref: Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein"
xref: Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein"
xref: Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3"
xref: Reactome:R-HSA-9734547 "JAK2-activated MAPKs phosphorylate YBX1"
xref: Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9"
xref: Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9"
xref: Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9"
xref: Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9"
xref: Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9"
xref: Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b"
xref: Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR"
xref: Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex"
xref: Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88"
xref: Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex"
xref: Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR"
xref: Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2"
xref: Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated"
xref: Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4"
xref: Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor"
xref: Reactome:R-HSA-9796067 "PRKAA2 phosphorylates nuclear NFE2L2"
xref: Reactome:R-HSA-9796081 "EIF2AK3 phosphorylates NFE2L2"
xref: Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320"
xref: Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189"
xref: Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25"
xref: Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357"
xref: Reactome:R-HSA-9824582 "MAPK1 phosphorylates SOX10"
xref: Reactome:R-HSA-9824897 "p-S-TBK1 phosphorylates OPTN"
xref: Reactome:R-HSA-9824977 "MAPK1-dependent phosphorylation of MITF-M"
xref: Reactome:R-HSA-9824994 "RPS6KA1-dependent phosphorylation of MITF-M"
xref: Reactome:R-HSA-9824995 "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405"
xref: Reactome:R-HSA-9824999 "GSK3B phosphorylates p-S73 MITF-M at residue S69"
xref: Reactome:R-HSA-9825704 "AKT3 phosphorylates TBX3"
xref: Reactome:R-HSA-9831514 "CK2 phosphorylates nascent P"
xref: Reactome:R-HSA-9831712 "M dimer is phosphorylated"
xref: Reactome:R-HSA-9832782 "p-S232-S237-P is further phosphorylated"
xref: Reactome:R-HSA-9834076 "PINK1 is autophosphorylated"
xref: Reactome:R-HSA-9834945 "PINK1 phosphorylates Ub on MOM proteins"
xref: Reactome:R-HSA-9835011 "PINK1 phosphorylates PRKN at S65"
xref: Reactome:R-HSA-9839363 "TGFBR3 phosphorylation by TGFBR2 complex"
xref: Reactome:R-HSA-9851972 "PLK1 phosphorylates FIRRM at S43"
xref: Reactome:R-HSA-9853369 "PLK1 phosphorylates FIRMM at S744"
xref: Reactome:R-HSA-9855910 "USF1 is phosphorylated by p-MAPK14"
xref: Reactome:R-HSA-9860292 "Activated IKBKB phosphorylates IRF5"
xref: Reactome:R-HSA-9860785 "PDPK1 (PDK1) phosphorylates PKN2 on threonine-816"
xref: Reactome:R-HSA-9860800 "mTORC2 phosphorylates AKT1 on serine-473"
xref: Reactome:R-HSA-9861642 "NEK1 phosphorylates ME1"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004675
name: transmembrane receptor protein serine/threonine kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [RHEA:18673]
synonym: "receptor protein serine/threonine kinase activity" RELATED [EC:2.7.11.30]
synonym: "receptor serine/threonine protein kinase activity" RELATED [EC:2.7.11.30]
xref: EC:2.7.11.30
xref: MetaCyc:2.7.11.30-RXN
xref: Reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly"
xref: Reactome:R-HSA-198732 "STAT3 activation"
xref: Reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly"
xref: RHEA:18673
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0004676
name: 3-phosphoinositide-dependent protein kinase activity
namespace: molecular_function
def: "Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]
comment: This reaction requires the presence of a phosphatidylinositol-3-phosphate.
synonym: "PDK activity" RELATED [PMID:10075713]
synonym: "phosphatidylinositol-3-phosphate protein kinase activity" EXACT []
xref: Reactome:R-HSA-437195 "PDPK1 activates PRKCZ"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004677
name: DNA-dependent protein kinase activity
namespace: molecular_function
def: "DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]
comment: This reaction requires the presence of DNA.
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004679
name: AMP-activated protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah]
synonym: "5'-AMP-activated protein kinase activity" EXACT []
synonym: "AMPK activity" RELATED [GOC:mah]
synonym: "protein kinase A activity" EXACT []
synonym: "SNF1A/AMP-activated protein kinase activity" NARROW []
xref: Reactome:R-HSA-1592244 "AMPK phosphorylates PPARGC1A"
xref: Reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 556 by AMPK"
xref: Reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis"
xref: Reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2"
xref: Reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex"
xref: Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex"
xref: Reactome:R-HSA-6805470 "AMPK phosphorylates TP53"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004680
name: obsolete casein kinase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004681
name: obsolete casein kinase I activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase I activity" EXACT []
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004682
name: obsolete protein kinase CK2 activity
namespace: molecular_function
alt_id: GO:0008604
def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase II activity" RELATED []
synonym: "casein kinase II, catalytic activity" EXACT []
synonym: "protein kinase CK2 activity" EXACT []
synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT []
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004683
name: calcium/calmodulin-dependent protein kinase activity
namespace: molecular_function
alt_id: GO:0004684
alt_id: GO:0004685
alt_id: GO:0004688
def: "Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. This activity require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17]
synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" RELATED [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase activity" RELATED [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/CaM-dependent kinase activity" EXACT []
synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT []
synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17]
synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17]
synonym: "calmodulin regulated protein kinase activity" EXACT []
synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17]
synonym: "calmodulin-dependent protein kinase activity" EXACT []
synonym: "calmodulin-dependent protein kinase I activity" NARROW []
synonym: "CaM kinase activity" RELATED [EC:2.7.11.17]
synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17]
synonym: "CAM PKII" RELATED [EC:2.7.11.17]
synonym: "CaM-regulated serine/threonine kinase activity" RELATED [EC:2.7.11.17]
synonym: "CaMKI" RELATED [EC:2.7.11.17]
synonym: "CaMKII" RELATED [EC:2.7.11.17]
synonym: "CaMKIV" RELATED [EC:2.7.11.17]
synonym: "CaMKKalpha" RELATED [EC:2.7.11.17]
synonym: "CaMKKbeta" RELATED [EC:2.7.11.17]
synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17]
synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED []
synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED []
synonym: "STK20" RELATED [EC:2.7.11.17]
xref: EC:2.7.11.17
xref: Reactome:R-HSA-111912 "CaMK4 phosphorylates CREB1"
xref: Reactome:R-HSA-111915 "CAMK4 autophosphorylates"
xref: Reactome:R-HSA-416320 "Trafficking of GluR1-containing  AMPA receptors"
xref: Reactome:R-HSA-442749 "CaMKK autophosphorylates in the nucleus"
xref: Reactome:R-HSA-9006992 "MECP2 is phosphorylated at S423"
xref: Reactome:R-HSA-9617583 "CaMKII autophosphorylates"
xref: Reactome:R-HSA-9618750 "CaMKII phosphorylates AMPA receptor"
xref: Reactome:R-HSA-9619125 "CaMKK phosphorylates CAMK4"
xref: Reactome:R-HSA-9619355 "CaMKK autophosphorylates in the cytosol"
xref: Reactome:R-HSA-9619367 "CaMKKs phosphorylate CAMK1"
xref: Reactome:R-HSA-9619478 "CAMKK2 phosphorylates AMPK"
xref: Reactome:R-HSA-9619783 "CAMK1 phosphorylates ARHGEF7-1"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004686
name: elongation factor-2 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN]
synonym: "ATP:elongation factor 2 phosphotransferase activity" RELATED [EC:2.7.11.20]
synonym: "Ca/CaM-kinase III activity" RELATED [EC:2.7.11.20]
synonym: "calmodulin-dependent protein kinase III activity" RELATED [EC:2.7.11.20]
synonym: "CaM kinase III activity" RELATED [EC:2.7.11.20]
synonym: "eEF-2 kinase activity" EXACT []
synonym: "eEF2 kinase activity" RELATED [EC:2.7.11.20]
synonym: "eEF2K" RELATED [EC:2.7.11.20]
synonym: "EF2K" RELATED [EC:2.7.11.20]
synonym: "elongation factor 2 kinase activity" RELATED [EC:2.7.11.20]
synonym: "eukaryotic elongation factor 2 kinase activity" RELATED [EC:2.7.11.20]
synonym: "STK19" RELATED [EC:2.7.11.20]
xref: EC:2.7.11.20
xref: MetaCyc:2.7.11.20-RXN
xref: RHEA:21436
is_a: GO:0004683 ! calcium/calmodulin-dependent protein kinase activity

[Term]
id: GO:0004687
name: myosin light chain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18]
synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18]
synonym: "ATP:myosin-light-chain O-phosphotransferase activity" RELATED [EC:2.7.11.18]
synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" RELATED [EC:2.7.11.18]
synonym: "MLCK" RELATED [EC:2.7.11.18]
synonym: "MLCkase activity" RELATED [EC:2.7.11.18]
synonym: "myosin kinase activity" RELATED [EC:2.7.11.18]
synonym: "myosin light chain protein kinase activity" RELATED [EC:2.7.11.18]
synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18]
synonym: "myosin light-chain kinase (phosphorylating)" RELATED [EC:2.7.11.18]
synonym: "myosin light-chain kinase (phosphorylating) activity" RELATED [EC:2.7.11.18]
synonym: "myosin light-chain kinase activity" RELATED [EC:2.7.11.18]
synonym: "myosin-light-chain kinase activity" EXACT []
synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18]
synonym: "STK18" RELATED [EC:2.7.11.18]
xref: EC:2.7.11.18
xref: MetaCyc:2.7.11.18-RXN
xref: Reactome:R-HSA-445813 "Phosphorylation of Smooth Muscle Myosin Light Chains"
xref: Reactome:R-HSA-5668978 "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex"
xref: RHEA:22004
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004689
name: phosphorylase kinase activity
namespace: molecular_function
alt_id: GO:0008606
def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19]
synonym: "ATP:phosphorylase-b phosphotransferase activity" RELATED [EC:2.7.11.19]
synonym: "dephosphophosphorylase kinase activity" RELATED [EC:2.7.11.19]
synonym: "glycogen phosphorylase kinase activity" RELATED [EC:2.7.11.19]
synonym: "PHK" RELATED [EC:2.7.11.19]
synonym: "phosphorylase B kinase activity" RELATED [EC:2.7.11.19]
synonym: "phosphorylase kinase (phosphorylating) activity" RELATED [EC:2.7.11.19]
synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT []
synonym: "STK17" RELATED [EC:2.7.11.19]
xref: EC:2.7.11.19
xref: MetaCyc:2.7.11.19-RXN
xref: Reactome:R-HSA-453337 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP"
xref: Reactome:R-HSA-71541 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP"
xref: Reactome:R-HSA-71588 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP"
is_a: GO:0004683 ! calcium/calmodulin-dependent protein kinase activity

[Term]
id: GO:0004690
name: cyclic nucleotide-dependent protein kinase activity
namespace: molecular_function
def: "cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]
comment: This reaction requires the presence of a cyclic nucleotide.
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004691
name: cAMP-dependent protein kinase activity
namespace: molecular_function
alt_id: GO:0008602
def: "cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [PMID:32935175, PMID:35053423, PMID:35805104]
comment: This reaction requires the presence of cAMP.
synonym: "3',5' cAMP-dependent protein kinase activity" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT []
synonym: "AMPK" RELATED [EC:2.7.11.11]
synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" RELATED [EC:2.7.11.11]
synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT []
synonym: "cyclic AMP-dependent protein kinase activity" EXACT []
synonym: "PKA" RELATED [EC:2.7.11.11]
synonym: "PKA C" RELATED [EC:2.7.11.11]
synonym: "protein kinase A activity" BROAD [EC:2.7.11.11]
synonym: "STK22" RELATED [EC:2.7.11.11]
xref: EC:2.7.11.11
xref: Reactome:R-HSA-163672 "Phosphorylation of ChREBP at Thr(653) by PKA"
xref: Reactome:R-HSA-163676 "Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA"
xref: Reactome:R-HSA-163773 "Phosphorylation of PF2K-Pase by PKA catalytic subunit"
xref: Reactome:R-HSA-177275 "PKA phosphorylates DARPP-32 on Thr34"
xref: Reactome:R-HSA-177284 "PKA phosphorylates PDE4B"
xref: Reactome:R-HSA-432232 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)"
xref: Reactome:R-HSA-5610717 "PKA phosphorylates GLI2"
xref: Reactome:R-HSA-5610720 "PKA phosphorylates GLI3"
xref: Reactome:R-HSA-5610741 "PKA phosphorylates GLI1"
xref: Reactome:R-HSA-5617179 "PRKACA phosphorylates TNNI3"
xref: Reactome:R-HSA-5617182 "PRKACA phosphorylates PLN"
xref: Reactome:R-HSA-5687088 "PKA phosphorylates MAPKAPK5"
xref: Reactome:R-HSA-913451 "IL3RB is phosphorylated on Ser-585"
xref: Reactome:R-HSA-9838321 "PRKACA phosphorylates TFAM in the mitochondrial matrix"
xref: Reactome:R-HSA-9861318 "PKA phosphorylates NOS3 (eNOS) on serine-633"
is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity

[Term]
id: GO:0004692
name: cGMP-dependent protein kinase activity
namespace: molecular_function
def: "cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]
comment: This reaction requires the presence of cGMP.
synonym: "3':5'-cyclic GMP-dependent protein kinase activity" RELATED [EC:2.7.11.12]
synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" RELATED [EC:2.7.11.12]
synonym: "cGMP-dependent protein kinase ibeta activity" RELATED [EC:2.7.11.12]
synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" RELATED [EC:2.7.11.12]
synonym: "PKG" RELATED [EC:2.7.11.12]
synonym: "PKG 1alpha" RELATED [EC:2.7.11.12]
synonym: "PKG 1beta" RELATED [EC:2.7.11.12]
synonym: "PKG II" RELATED [EC:2.7.11.12]
synonym: "STK23" RELATED [EC:2.7.11.12]
xref: EC:2.7.11.12
xref: Reactome:R-HSA-1475422 "PTPS is phosphorylated by cGMP-dependant protein kinase II"
xref: Reactome:R-HSA-1497853 "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II"
xref: Reactome:R-HSA-418442 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release"
xref: Reactome:R-HSA-418549 "PKG1 phosphorylates BK channels"
is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity

[Term]
id: GO:0004693
name: cyclin-dependent protein serine/threonine kinase activity
namespace: molecular_function
alt_id: GO:0016537
def: "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
comment: This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
synonym: "ATP:cyclin phosphotransferase activity" RELATED [EC:2.7.11.22]
synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22]
synonym: "CDK" RELATED [EC:2.7.11.22]
synonym: "CDK activity" EXACT []
synonym: "CDK, catalytic subunit activity" EXACT []
synonym: "cdk-activating kinase activity" RELATED [EC:2.7.11.22]
synonym: "Cdk-activating protein kinase activity" RELATED [EC:2.7.11.22]
synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22]
synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent protein kinase activity" BROAD []
synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT []
synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22]
synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22]
xref: EC:2.7.11.22
xref: Reactome:R-HSA-1226094 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex"
xref: Reactome:R-HSA-1226095 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex"
xref: Reactome:R-HSA-174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:R-HSA-174122 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2"
xref: Reactome:R-HSA-174132 "Free APC/C phosphorylated by Cyclin B:Cdc2"
xref: Reactome:R-HSA-174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:R-HSA-180047 "CDK5 phosphorylates DARPP-32 on Thr75"
xref: Reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21"
xref: Reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21"
xref: Reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2"
xref: Reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)"
xref: Reactome:R-HSA-188390 "Cyclin E:CDK2-mediated phosphorylation of RB1"
xref: Reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8"
xref: Reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB"
xref: Reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants"
xref: Reactome:R-HSA-2245218 "CDK1 phosphorylates PHF8"
xref: Reactome:R-HSA-2294600 "CDK1 phosphorylates condensin II subunit NCAPD3"
xref: Reactome:R-HSA-2430533 "CDK1 phosphorylates MASTL"
xref: Reactome:R-HSA-2468287 "CDK1 phosphorylates CDCA5 (Sororin) at centromeres"
xref: Reactome:R-HSA-2468293 "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms"
xref: Reactome:R-HSA-2514854 "CDK1 phosphorylates condensin I"
xref: Reactome:R-HSA-2984220 "CDK1:CCNB phosphorylates NEK9"
xref: Reactome:R-HSA-2990882 "CDK1 phosphorylates NUP98"
xref: Reactome:R-HSA-3788705 "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:R-HSA-380278 "CCNB1:p-T160-CDK1 phosphorylates NUMA1"
xref: Reactome:R-HSA-4086410 "CDK1 phosphorylates BORA"
xref: Reactome:R-HSA-4088024 "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1"
xref: Reactome:R-HSA-5195402 "CDK1 phosphorylates LPIN"
xref: Reactome:R-HSA-5244669 "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments"
xref: Reactome:R-HSA-5692755 "CDK1 phosphorylates MAPK6"
xref: Reactome:R-HSA-6793661 "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218"
xref: Reactome:R-HSA-6797606 "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes"
xref: Reactome:R-HSA-6805109 "CDK2 phosphorylates TP53"
xref: Reactome:R-HSA-68944 "Orc1 is phosphorylated by cyclin A/CDK2"
xref: Reactome:R-HSA-69005 "Cdc6 protein is phosphorylated by CDK"
xref: Reactome:R-HSA-69227 "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes"
xref: Reactome:R-HSA-69754 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes"
xref: Reactome:R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes"
xref: Reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2"
xref: Reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2"
xref: Reactome:R-HSA-9624800 "CDK1 phosphorylates LBR"
xref: Reactome:R-HSA-9686521 "CDK2:CCNA phosphorylates TERF2"
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0097472 ! cyclin-dependent protein kinase activity

[Term]
id: GO:0004694
name: eukaryotic translation initiation factor 2alpha kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [GOC:mah, InterPro:IPR015516]
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004697
name: diacylglycerol-dependent serine/threonine kinase activity
namespace: molecular_function
alt_id: GO:0004701
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" RELATED [EC:2.7.11.13]
synonym: "cPKC" RELATED [EC:2.7.11.13]
synonym: "cPKCalpha" RELATED [EC:2.7.11.13]
synonym: "cPKCbeta" RELATED [EC:2.7.11.13]
synonym: "cPKCgamma" RELATED [EC:2.7.11.13]
synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT []
synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT []
synonym: "nPKC" RELATED [EC:2.7.11.13]
synonym: "nPKCdelta" RELATED [EC:2.7.11.13]
synonym: "nPKCepsilon" RELATED [EC:2.7.11.13]
synonym: "nPKCeta" RELATED [EC:2.7.11.13]
synonym: "nPKCtheta" RELATED [EC:2.7.11.13]
synonym: "PKC" RELATED [EC:2.7.11.13]
synonym: "PKC activity" EXACT []
synonym: "Pkc1p" RELATED [EC:2.7.11.13]
synonym: "PKCalpha" RELATED [EC:2.7.11.13]
synonym: "PKCbeta" RELATED [EC:2.7.11.13]
synonym: "PKCdelta" RELATED [EC:2.7.11.13]
synonym: "PKCepsilon" RELATED [EC:2.7.11.13]
synonym: "PKCgamma" RELATED [EC:2.7.11.13]
synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13]
synonym: "STK24" RELATED [EC:2.7.11.13]
xref: EC:2.7.11.13
xref: Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT"
xref: Reactome:R-HSA-193703 "IKKbeta is activated"
xref: Reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta"
xref: Reactome:R-HSA-2179413 "Activated PKC-alpha  activate MMP3"
xref: Reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta"
xref: Reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin"
xref: Reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates CERT1-2"
xref: Reactome:R-HSA-450533 "PKCdelta phosphorylates HuR"
xref: Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR"
xref: Reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC"
xref: Reactome:R-HSA-5218805 "PKC autophosphorylates"
xref: Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1"
xref: Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation"
xref: Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3"
xref: Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters"
xref: Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C"
xref: Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP"
xref: Reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)"
xref: Reactome:R-HSA-8932284 "PKC phosphorylates NFE2L2"
xref: Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1"
xref: Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1"
xref: Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3"
xref: Reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727"
xref: Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)"
xref: Reactome:R-HSA-9626817 "PKC phosphorylates NCF1"
xref: Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation"
xref: Reactome:R-HSA-9796053 "PRKCI phosphorylates NFE2L2"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004698
name: calcium,diacylglycerol-dependent serine/threonine kinase activity
namespace: molecular_function
def: "Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction is activated in the presence of diacylglycerol and calcium." [PMID:34834162]
synonym: "calcium-dependent PKC activity" EXACT []
synonym: "conventional protein kinase C activity" EXACT [PMID:9601053]
xref: Reactome:R-HSA-114683 "Phosphorylation of Platelet Sec-1"
xref: Reactome:R-HSA-114684 "Phosphorylation of Syntaxin-4"
xref: Reactome:R-HSA-416639 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites"
xref: Reactome:R-HSA-421007 "Endocytosis of Ca impermeable AMPA receptors"
xref: Reactome:R-HSA-8986937 "MECP2 is phosphorylated at T308"
xref: Reactome:R-HSA-9005561 "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308"
is_a: GO:0004697 ! diacylglycerol-dependent serine/threonine kinase activity
is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity

[Term]
id: GO:0004699
name: diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction is activated by diacylglycerol but not by calcium." [PMID:34834162]
synonym: "atypical protein kinase C activity" RELATED []
synonym: "calcium-independent PKC activity" EXACT []
synonym: "novel protein kinase C activity" EXACT [PMID:9601053]
xref: Reactome:R-HSA-5607740 "PKC-delta phosphorylates CARD9"
is_a: GO:0004697 ! diacylglycerol-dependent serine/threonine kinase activity

[Term]
id: GO:0004702
name: obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity
namespace: molecular_function
def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, GOC:mah]
comment: This term was obsoleted because it was not clearly defined.
synonym: "receptor signaling protein serine/threonine kinase activity" EXACT []
synonym: "receptor signalling protein serine/threonine kinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0004703
name: G protein-coupled receptor kinase activity
namespace: molecular_function
alt_id: GO:0004678
def: "Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate." [GOC:dph]
synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" RELATED [EC:2.7.11.16]
synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT []
synonym: "G-protein coupled receptor kinase activity" RELATED [EC:2.7.11.16]
synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT []
synonym: "GPCR kinase activity" RELATED [EC:2.7.11.16]
synonym: "GPCR phosphorylating protein kinase activity" EXACT []
synonym: "GPCRK" RELATED [EC:2.7.11.16]
synonym: "GRK4" RELATED [EC:2.7.11.16]
synonym: "GRK5" RELATED [EC:2.7.11.16]
synonym: "GRK6" RELATED [EC:2.7.11.16]
synonym: "STK16" RELATED [EC:2.7.11.16]
xref: EC:2.7.11.16
xref: RHEA:12008
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004704
name: obsolete NF-kappaB-inducing kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)." [PMID:20685151]
comment: This terms was obsoleted because it represents a specific gene product and it was instantiated as an enzyme regulator, but it is actually a protein kinase)This
synonym: "NIK" EXACT []
is_obsolete: true

[Term]
id: GO:0004705
name: JUN kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732]
synonym: "c-Jun N-terminal kinase activity" NARROW []
synonym: "JNK" EXACT []
synonym: "JNK3alpha1" RELATED []
synonym: "SAPK1" NARROW []
xref: Reactome:R-HSA-168136 "Activated JNKs phosphorylate c-JUN"
xref: Reactome:R-HSA-204949 "NRIF and TRAF6 may activate JNK"
xref: Reactome:R-HSA-205075 "JNK phosphorylates BIM, BAD and other targets"
xref: Reactome:R-HSA-205132 "NRAGE activates JNK"
xref: Reactome:R-HSA-9673789 "Activated JNK phosphorylates c-JUN"
is_a: GO:0004707 ! MAP kinase activity

[Term]
id: GO:0004706
name: JUN kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf]
synonym: "JNK kinase kinase activity" RELATED []
synonym: "JNKKK" EXACT []
is_a: GO:0004709 ! MAP kinase kinase kinase activity

[Term]
id: GO:0004707
name: MAP kinase activity
namespace: molecular_function
alt_id: GO:0008338
alt_id: GO:0008339
alt_id: GO:0016908
alt_id: GO:0016909
def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]
synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" RELATED [EC:2.7.11.24]
synonym: "ERK" RELATED [EC:2.7.11.24]
synonym: "ERK1" EXACT []
synonym: "ERK2" RELATED []
synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24]
synonym: "MAP kinase 1 activity" NARROW []
synonym: "MAP kinase 2 activity" NARROW []
synonym: "MAPK" RELATED [EC:2.7.11.24, PMID:20811974]
synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24]
synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24]
synonym: "mitogen activated kinase activity" EXACT []
synonym: "mitogen-activated protein kinase activity" RELATED [EC:2.7.11.24]
synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24]
synonym: "SAP kinase activity" NARROW []
synonym: "SAPK" NARROW []
synonym: "stress-activated kinase activity" NARROW []
synonym: "stress-activated protein kinase activity" NARROW []
xref: EC:2.7.11.24
xref: KEGG_REACTION:R00162
xref: MetaCyc:2.7.11.24-RXN
xref: Reactome:R-HSA-111898 "Phosphorylation of cPLA2 by ERK-2"
xref: Reactome:R-HSA-198733 "ERK5 is activated"
xref: Reactome:R-HSA-445079 "Phosphorylation of L1 by ERK"
xref: Reactome:R-HSA-5654560 "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2"
xref: Reactome:R-HSA-5654562 "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2"
xref: Reactome:R-HSA-5654565 "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2"
xref: Reactome:R-HSA-5654566 "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2"
xref: Reactome:R-HSA-73722 "Phosphorylation of UBF-1:rDNA Promoter"
xref: Reactome:R-HSA-9626832 "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345"
xref: Reactome:R-HSA-9825759 "MAPK-dependent phosphorylation of KARS"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004708
name: MAP kinase kinase activity
namespace: molecular_function
def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a T-X-Y motif in the activation loop of a MAP kinase (MAPK) substrate." [PMID:12623839, PMID:38270553]
synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" RELATED [EC:2.7.12.2]
synonym: "ERK activator kinase activity" EXACT []
synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2]
synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2]
synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2]
synonym: "MAP2K" RELATED [EC:2.7.12.2]
synonym: "MAPK activator activity" EXACT [GOC:vw]
synonym: "MAPKK" RELATED [EC:2.7.12.2, PMID:20811974]
synonym: "MAPKK activity" EXACT []
synonym: "MAPKK1" RELATED [EC:2.7.12.2]
synonym: "MEK activity" BROAD []
synonym: "MEK1" RELATED [EC:2.7.12.2]
synonym: "MEK2" RELATED [EC:2.7.12.2]
synonym: "mitogen-activated protein kinase kinase activity" RELATED [EC:2.7.12.2]
synonym: "MKK" RELATED [EC:2.7.12.2]
synonym: "MKK2" RELATED [EC:2.7.12.2]
synonym: "MKK4" RELATED [EC:2.7.12.2]
synonym: "MKK6" RELATED [EC:2.7.12.2]
synonym: "MKK7" RELATED [EC:2.7.12.2]
synonym: "STK27" RELATED [EC:2.7.12.2]
xref: EC:2.7.12.2
xref: MetaCyc:2.7.12.2-RXN
xref: Reactome:R-HSA-1247960 "Activation of p38 MAPK"
xref: Reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5"
xref: Reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK"
xref: Reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3"
xref: Reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR"
is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity

[Term]
id: GO:0004709
name: MAP kinase kinase kinase activity
namespace: molecular_function
alt_id: GO:0004710
def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" RELATED [EC:2.7.11.25]
synonym: "cMos" RELATED [EC:2.7.11.25]
synonym: "cRaf" RELATED [EC:2.7.11.25]
synonym: "MAP3K" RELATED [EC:2.7.11.25, PMID:20811974]
synonym: "MAPK/ERK kinase kinase activity" EXACT []
synonym: "MAPKKK activity" RELATED [EC:2.7.11.25]
synonym: "MEK kinase activity" RELATED [EC:2.7.11.25]
synonym: "MEKK" RELATED [EC:2.7.11.25]
synonym: "MEKK activity" EXACT []
synonym: "MEKK1" RELATED [EC:2.7.11.25]
synonym: "MEKK2" RELATED [EC:2.7.11.25]
synonym: "MEKK3" RELATED [EC:2.7.11.25]
synonym: "Mil/Raf" RELATED [EC:2.7.11.25]
synonym: "mitogen-activated protein kinase kinase kinase activity" RELATED [EC:2.7.11.25]
synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25]
synonym: "MLTK" RELATED [EC:2.7.11.25]
synonym: "MLTKa" RELATED [EC:2.7.11.25]
synonym: "MLTKb" RELATED [EC:2.7.11.25]
synonym: "REKS" RELATED [EC:2.7.11.25]
synonym: "STK28" RELATED [EC:2.7.11.25]
xref: EC:2.7.11.25
xref: MetaCyc:2.7.11.25-RXN
xref: Reactome:R-HSA-2730887 "Autophosphorylation and activation of MEKK1"
xref: Reactome:R-HSA-392530 "p-S400-Cot phosphorylates NIK"
xref: Reactome:R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1"
xref: Reactome:R-HSA-727819 "TAK1 phosphorylates MKK6"
xref: Reactome:R-HSA-933530 "Activation of IKK by MEKK1"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004711
name: ribosomal protein S6 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004712
name: protein serine/threonine/tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
synonym: "dual-specificity kinase activity" EXACT [EC:2.7.12.1]
synonym: "dual-specificity protein kinase" EXACT []
synonym: "protein threonine/tyrosine kinase activity" NARROW []
xref: EC:2.7.12.1
xref: Reactome:R-HSA-5672969 "Phosphorylation of RAF"
xref: Reactome:R-HSA-5674373 "MAP2Ks phosphorylate MAPK at the Golgi membrane"
xref: Reactome:R-HSA-6802910 "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants"
xref: Reactome:R-HSA-6802916 "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants"
xref: Reactome:R-HSA-6802918 "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants"
xref: Reactome:R-HSA-6802921 "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants"
xref: Reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS"
xref: Reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS"
xref: Reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated"
xref: Reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF"
xref: Reactome:R-HSA-9656212 "Phosphorylation of RAF1 mutants"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004713
name: protein tyrosine kinase activity
namespace: molecular_function
alt_id: GO:0004718
def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]
synonym: "protein-tyrosine kinase activity" EXACT []
xref: EC:2.7.10.-
xref: MetaCyc:2.7.10.1-RXN
xref: Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1"
xref: Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma"
xref: Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation"
xref: Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers"
xref: Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants"
xref: Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants"
xref: Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants"
xref: Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers"
xref: Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer"
xref: Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers"
xref: Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers"
xref: Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers"
xref: Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2"
xref: Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5"
xref: Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227"
xref: Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4"
xref: Reactome:R-HSA-1433418 "Phosphorylation of JAK2"
xref: Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs"
xref: Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs"
xref: Reactome:R-HSA-1433506 "Phosphorylation of APS"
xref: Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1"
xref: Reactome:R-HSA-1470009 "Phosphorylation of STATs"
xref: Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases"
xref: Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR"
xref: Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated"
xref: Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes"
xref: Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes"
xref: Reactome:R-HSA-170991 "SRC-1 autophosphorylates"
xref: Reactome:R-HSA-171011 "Binding and activation of MAP Kinase"
xref: Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15"
xref: Reactome:R-HSA-177934 "EGFR autophosphorylation"
xref: Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase"
xref: Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)"
xref: Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)"
xref: Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers"
xref: Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1"
xref: Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1"
xref: Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2"
xref: Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions"
xref: Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors"
xref: Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3"
xref: Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4"
xref: Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b"
xref: Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c"
xref: Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b"
xref: Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c"
xref: Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b"
xref: Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c"
xref: Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c"
xref: Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src"
xref: Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers"
xref: Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers"
xref: Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2"
xref: Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1"
xref: Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant"
xref: Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants"
xref: Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant"
xref: Reactome:R-HSA-201521 "ALK autophosphorylation"
xref: Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes"
xref: Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck"
xref: Reactome:R-HSA-202174 "Activation of ZAP-70"
xref: Reactome:R-HSA-202216 "Phosphorylation of SLP-76"
xref: Reactome:R-HSA-202233 "Inactivation of Lck by Csk"
xref: Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT"
xref: Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1"
xref: Reactome:R-HSA-202291 "Activation of Lck"
xref: Reactome:R-HSA-202307 "Change of PKC theta conformation"
xref: Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers"
xref: Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity"
xref: Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG"
xref: Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases"
xref: Reactome:R-HSA-2029453 "Phosphorylation of VAV"
xref: Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts"
xref: Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent  mutants"
xref: Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants"
xref: Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity"
xref: Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding"
xref: Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding"
xref: Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity"
xref: Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants"
xref: Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity"
xref: Reactome:R-HSA-205289 "Autophosphorylation of KIT"
xref: Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src"
xref: Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2"
xref: Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation"
xref: Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs"
xref: Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP"
xref: Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK"
xref: Reactome:R-HSA-2395412 "Phosphorylation of SYK"
xref: Reactome:R-HSA-2395439 "Phosphorylation of DAP12"
xref: Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK"
xref: Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK"
xref: Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1"
xref: Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates"
xref: Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK"
xref: Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK"
xref: Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK"
xref: Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4"
xref: Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN"
xref: Reactome:R-HSA-2454239 "Phosphorylation of SYK"
xref: Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR"
xref: Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin"
xref: Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin"
xref: Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin"
xref: Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin"
xref: Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK"
xref: Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK"
xref: Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK"
xref: Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK"
xref: Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN"
xref: Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase"
xref: Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta"
xref: Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn"
xref: Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase"
xref: Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma"
xref: Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F"
xref: Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397"
xref: Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC"
xref: Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex"
xref: Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN"
xref: Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2"
xref: Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn"
xref: Reactome:R-HSA-377640 "Autophosphorylation of SRC"
xref: Reactome:R-HSA-380780 "Activation of Src"
xref: Reactome:R-HSA-388831 "Phosphorylation of CD28"
xref: Reactome:R-HSA-388833 "Phosphorylation of CTLA-4"
xref: Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors"
xref: Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors"
xref: Reactome:R-HSA-389159 "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues"
xref: Reactome:R-HSA-389354 "Activation of Vav1"
xref: Reactome:R-HSA-389762 "Phosphorylation of PD-1"
xref: Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha"
xref: Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts"
xref: Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase"
xref: Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn"
xref: Reactome:R-HSA-3928578 "EPH receptors autophosphorylate"
xref: Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs"
xref: Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B"
xref: Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1"
xref: Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3"
xref: Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397"
xref: Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1"
xref: Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF"
xref: Reactome:R-HSA-399934 "Phosphorylation of Plexin-A"
xref: Reactome:R-HSA-399946 "Recruitment and activation of Cdk5"
xref: Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes"
xref: Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2"
xref: Reactome:R-HSA-418163 "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)"
xref: Reactome:R-HSA-418859 "Phosphorylation of Unc5C"
xref: Reactome:R-HSA-418872 "Phosphorylation of FADK1"
xref: Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met"
xref: Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase"
xref: Reactome:R-HSA-429441 "SYK activation by SRC"
xref: Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation"
xref: Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8"
xref: Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT"
xref: Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates"
xref: Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1"
xref: Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB"
xref: Reactome:R-HSA-4420206 "Phosphorylation of SRC-1"
xref: Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2"
xref: Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1"
xref: Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC"
xref: Reactome:R-HSA-445085 "Phosphorylation of VAV2"
xref: Reactome:R-HSA-445091 "Phosphorylation of Neurofascin"
xref: Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1"
xref: Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated"
xref: Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated"
xref: Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB"
xref: Reactome:R-HSA-508282 "SYK is a substrate for JAK1"
xref: Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2"
xref: Reactome:R-HSA-5218642 "PTK2 autophosphorylates"
xref: Reactome:R-HSA-5218806 "FYN autophosphorylates"
xref: Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118"
xref: Reactome:R-HSA-5218812 "FYN phosphorylates PAK2"
xref: Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV"
xref: Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1"
xref: Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta"
xref: Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407"
xref: Reactome:R-HSA-5357429 "AXL autophosphorylates on Y779 and Y821"
xref: Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG"
xref: Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan"
xref: Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG"
xref: Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2"
xref: Reactome:R-HSA-5621370 "SYK autophosphorylates"
xref: Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341"
xref: Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant"
xref: Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII"
xref: Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1"
xref: Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1"
xref: Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1"
xref: Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1"
xref: Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2"
xref: Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1"
xref: Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2"
xref: Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2"
xref: Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1"
xref: Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c"
xref: Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2"
xref: Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3"
xref: Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1"
xref: Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11"
xref: Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3"
xref: Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11"
xref: Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3"
xref: Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11"
xref: Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1"
xref: Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3"
xref: Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11"
xref: Reactome:R-HSA-5655243 "Activated FGFR3 point and translocation mutants phosphorylate PLCG1"
xref: Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2"
xref: Reactome:R-HSA-5655270 "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2"
xref: Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2"
xref: Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2"
xref: Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1"
xref: Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1"
xref: Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142"
xref: Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52"
xref: Reactome:R-HSA-5690702 "LYN phosphorylates CD22"
xref: Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2"
xref: Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2"
xref: Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation"
xref: Reactome:R-HSA-6806974 "MET dimers autophosphorylate"
xref: Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK"
xref: Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1"
xref: Reactome:R-HSA-873918 "Transphosphorylation of JAK1"
xref: Reactome:R-HSA-873919 "Phosphorylation of JAK2"
xref: Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases"
xref: Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases"
xref: Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor"
xref: Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2"
xref: Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated"
xref: Reactome:R-HSA-8847977 "FRK phosphorylates PTEN"
xref: Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation"
xref: Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2"
xref: Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3"
xref: Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B"
xref: Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN"
xref: Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1"
xref: Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1"
xref: Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1"
xref: Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL"
xref: Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1"
xref: Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1"
xref: Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2"
xref: Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3"
xref: Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35"
xref: Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6"
xref: Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ"
xref: Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2"
xref: Reactome:R-HSA-8851933 "MET phosphorylates GAB1"
xref: Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions"
xref: Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate"
xref: Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate"
xref: Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1"
xref: Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB"
xref: Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation"
xref: Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6"
xref: Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307"
xref: Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15"
xref: Reactome:R-HSA-8874078 "PTK2 autophosphorylates"
xref: Reactome:R-HSA-8874080 "SRC phosphorylates PTK2"
xref: Reactome:R-HSA-8874082 "MET phosphorylates PTK2"
xref: Reactome:R-HSA-8875451 "MET phosphorylates CBL"
xref: Reactome:R-HSA-8875817 "MET phosphorylates STAT3"
xref: Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates"
xref: Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL"
xref: Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1"
xref: Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1"
xref: Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3"
xref: Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1"
xref: Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes"
xref: Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18"
xref: Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1"
xref: Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC"
xref: Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC"
xref: Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4"
xref: Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR"
xref: Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin"
xref: Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1"
xref: Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2"
xref: Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3"
xref: Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates"
xref: Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1"
xref: Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate"
xref: Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate"
xref: Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate"
xref: Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1"
xref: Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1"
xref: Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2"
xref: Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1"
xref: Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2"
xref: Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2"
xref: Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1"
xref: Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1"
xref: Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3"
xref: Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates"
xref: Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B"
xref: Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5"
xref: Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation"
xref: Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate"
xref: Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1"
xref: Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1"
xref: Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2"
xref: Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer"
xref: Reactome:R-HSA-909726 "Phosphorylation of STAT1"
xref: Reactome:R-HSA-909729 "Activation of JAK kinases"
xref: Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2"
xref: Reactome:R-HSA-909732 "Phosphorylation of STAT2"
xref: Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated"
xref: Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation"
xref: Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates"
xref: Reactome:R-HSA-9606159 "BTK autophosphorylates"
xref: Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2"
xref: Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK"
xref: Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs"
xref: Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates"
xref: Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates"
xref: Reactome:R-HSA-9624014 "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1"
xref: Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR"
xref: Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1"
xref: Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK"
xref: Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers"
xref: Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect"
xref: Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate"
xref: Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1"
xref: Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1"
xref: Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate"
xref: Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1"
xref: Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1"
xref: Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1"
xref: Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate"
xref: Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3"
xref: Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants"
xref: Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants"
xref: Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants"
xref: Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants"
xref: Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers"
xref: Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers"
xref: Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins"
xref: Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB"
xref: Reactome:R-HSA-9674558 "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1"
xref: Reactome:R-HSA-9674567 "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2"
xref: Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants"
xref: Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants"
xref: Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2"
xref: Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5"
xref: Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B"
xref: Reactome:R-HSA-9700164 "Active ALK phosphorylates FRS2"
xref: Reactome:R-HSA-9700168 "Active ALK phosphorylates IRS1"
xref: Reactome:R-HSA-9700171 "Active ALK phosphorylates PLCG1"
xref: Reactome:R-HSA-9700175 "Active ALK phosphorylates SHC1"
xref: Reactome:R-HSA-9700181 "Autophosphorylation of ALK fusions"
xref: Reactome:R-HSA-9700186 "Autophosphorylation of point mutants of ALK"
xref: Reactome:R-HSA-9700193 "ALK mutants phosphorylate SHC1"
xref: Reactome:R-HSA-9700647 "Active ALK phosphorylates SRC"
xref: Reactome:R-HSA-9701488 "Active ALK phosphorylates JAK3"
xref: Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate"
xref: Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2"
xref: Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10"
xref: Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL"
xref: Reactome:R-HSA-9709918 "PTK6 phosphorylates STAT3"
xref: Reactome:R-HSA-9712082 "ALK fusions phosphorylate IRS1"
xref: Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3"
xref: Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1"
xref: Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS"
xref: Reactome:R-HSA-9726848 "SRC phosphorylates RHOU"
xref: Reactome:R-HSA-9732738 "JAK1-mediated phosphorylation of RAF1"
xref: Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561"
xref: Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL"
xref: Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 483"
xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR"
xref: Reactome:R-HSA-9831136 "SH pentamer is phosphorylated"
xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)"
xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR"
xref: Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)"
xref: Reactome:R-HSA-9841924 "ABL1 phosphorylates PPARG2"
xref: Reactome:R-HSA-9842648 "Autophosphorylation of LTK dimer:ALKAL1,2"
xref: Reactome:R-HSA-9842651 "Active LTK receptor phosphorylates SHC1"
xref: Reactome:R-HSA-9842666 "Active LTK phosphorylates IRS1"
xref: Reactome:R-HSA-9842667 "CLIP1-LTK fusion autophosphorylates"
xref: Reactome:R-HSA-9860500 "Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1"
xref: Reactome:R-HSA-9860759 "p-T816-PKN2 phosphorylates AKT1 on serine-308"
xref: Reactome:R-HSA-9861469 "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)"
xref: Reactome:R-HSA-9865196 "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1"
xref: RHEA:10596
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004714
name: transmembrane receptor protein tyrosine kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
synonym: "receptor protein tyrosine kinase activity" RELATED [EC:2.7.10.1]
synonym: "receptor protein-tyrosine kinase activity" RELATED [EC:2.7.10.1]
xref: EC:2.7.10.1
xref: Reactome:R-HSA-166544 "TrkA receptor autophosphorylates"
xref: Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated"
xref: Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1"
xref: Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor"
xref: Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase"
xref: Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR"
xref: Reactome:R-HSA-198295 "TRKA phosphorylates IRS"
xref: Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA"
xref: Reactome:R-HSA-74711 "Phosphorylation of IRS"
xref: Reactome:R-HSA-74742 "Phosphorylation of SHC1"
xref: Reactome:R-HSA-8852552 "MST1R autophosphorylates"
xref: Reactome:R-HSA-8853792 "RET tyrosine phosphorylation"
xref: Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor"
xref: Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation"
xref: Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction"
xref: Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated"
xref: Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated"
xref: Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated"
xref: Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4"
xref: Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction"
xref: Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated"
xref: Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated"
xref: Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated"
xref: Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
xref: Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1"
xref: Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1"
xref: Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5"
xref: Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2"
xref: Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5"
xref: Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2"
xref: Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA"
xref: Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1"
xref: Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1"
xref: Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
xref: Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3"
xref: Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1"
xref: Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
xref: Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated"
xref: Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3"
xref: Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3"
xref: Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3"
xref: Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
xref: Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3"
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0004715
name: non-membrane spanning protein tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]
synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" RELATED [EC:2.7.10.2]
synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2]
synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2]
synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2]
synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2]
synonym: "non-specific protein-tyrosine kinase activity" RELATED [EC:2.7.10.2]
synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2]
xref: EC:2.7.10.2
xref: Reactome:R-HSA-1112602 "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor"
xref: Reactome:R-HSA-1112703 "PTPN11 is phosphorylated"
xref: Reactome:R-HSA-1168423 "JAK2 phosphorylation of IRS-1/2"
xref: Reactome:R-HSA-1168459 "Lyn activates ERK"
xref: Reactome:R-HSA-1168767 "JAK2 phosphorylates STAT1/STAT3"
xref: Reactome:R-HSA-1295519 "IL7R is phosphorylated on Y499"
xref: Reactome:R-HSA-1369115 "SHP2 is phosphorylated"
xref: Reactome:R-HSA-432148 "Fgr may phosphorylate p38 MAPK"
xref: Reactome:R-HSA-437936 "p-Y348-SYK phosphorylates VAV family"
xref: Reactome:R-HSA-453200 "SYK autophosphorylates"
xref: Reactome:R-HSA-6786095 "JAK1 phosphorylates STAT3,STAT6"
xref: Reactome:R-HSA-6786096 "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated"
xref: Reactome:R-HSA-6788582 "STAT1,STAT3,STAT6 phosphorylation"
xref: Reactome:R-HSA-879910 "JAK2 is phosphorylated, activated"
xref: Reactome:R-HSA-8871373 "BMX phosphorylates RUFY1"
is_a: GO:0004713 ! protein tyrosine kinase activity

[Term]
id: GO:0004716
name: obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity
namespace: molecular_function
def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:curators]
comment: This term was obsoleted because it was not clearly defined.
synonym: "receptor signaling protein tyrosine kinase activity" EXACT []
synonym: "receptor signalling protein tyrosine kinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0004717
name: obsolete focal adhesion kinase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function.
synonym: "FAK" EXACT []
synonym: "focal adhesion kinase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004713

[Term]
id: GO:0004719
name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]
synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein (D-aspartate) methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein beta-aspartate O-methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein D-aspartate methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein L-isoaspartate methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein L-isoaspartyl methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein O-methyltransferase (L-isoaspartate)" RELATED [EC:2.1.1.77]
synonym: "protein-beta-aspartate O-methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein-L-isoaspartate O-methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" RELATED [EC:2.1.1.77]
synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" RELATED [EC:2.1.1.77]
xref: EC:2.1.1.77
xref: MetaCyc:2.1.1.77-RXN
xref: Reactome:R-HSA-5676966 "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp"
xref: RHEA:12705
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity

[Term]
id: GO:0004720
name: protein-lysine 6-oxidase activity
namespace: molecular_function
alt_id: GO:0018056
def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13]
synonym: "lysyl oxidase activity" RELATED [EC:1.4.3.13]
synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" RELATED [EC:1.4.3.13]
xref: EC:1.4.3.13
xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN
xref: Reactome:R-HSA-2002466 "Formation of allysine by LOX"
xref: Reactome:R-HSA-2129375 "Elastin cross-linking by lysyl oxidase"
xref: Reactome:R-HSA-2395340 "Formation of hydroxyallysine by LOX"
xref: RHEA:24544
is_a: GO:0052597 ! diamine oxidase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004721
name: phosphoprotein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]
synonym: "phosphoprotein phosphohydrolase activity" EXACT []
synonym: "protein phosphatase activity" EXACT []
synonym: "protein phosphatase-1 activity" NARROW []
synonym: "protein phosphatase-2A activity" NARROW []
synonym: "protein phosphatase-2B activity" NARROW []
synonym: "protein phosphatase-2C activity" NARROW []
xref: Reactome:R-HSA-112383 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein"
xref: Reactome:R-HSA-113503 "PP2A mediated localization of RB1 protein in chromatin"
xref: Reactome:R-HSA-1363274 "Dephosphorylation of p107 (RBL1) by PP2A"
xref: Reactome:R-HSA-1363276 "Dephosphorylation of p130 (RBL2) by PP2A"
xref: Reactome:R-HSA-167072 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein"
xref: Reactome:R-HSA-170153 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases"
xref: Reactome:R-HSA-170158 "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes"
xref: Reactome:R-HSA-170161 "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B"
xref: Reactome:R-HSA-174110 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2"
xref: Reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1"
xref: Reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1"
xref: Reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I"
xref: Reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A"
xref: Reactome:R-HSA-9636684 "NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP"
is_a: GO:0016791 ! phosphatase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004722
name: protein serine/threonine phosphatase activity
namespace: molecular_function
alt_id: GO:0000158
alt_id: GO:0000163
alt_id: GO:0004724
alt_id: GO:0008598
alt_id: GO:0008600
alt_id: GO:0015071
alt_id: GO:0030357
alt_id: GO:0030358
alt_id: GO:0030360
alt_id: GO:0030361
alt_id: GO:0106306
alt_id: GO:0106307
def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
synonym: "magnesium-dependent protein serine/threonine phosphatase activity" RELATED []
synonym: "phosphatase I" NARROW []
synonym: "phosphatase II" NARROW []
synonym: "phosphatase III" NARROW []
synonym: "protein phosphatase type 1 activity" NARROW []
synonym: "protein phosphatase type 2A activity" NARROW []
synonym: "protein phosphatase type 2B activity" NARROW []
synonym: "protein phosphatase type 2C activity" NARROW []
synonym: "protein phosphatase-1" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2A" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2B" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2C" NARROW [EC:3.1.3.16]
synonym: "protein serine phosphatase activity" NARROW []
synonym: "protein threonine phosphatase activity" NARROW []
synonym: "serine/threonine specific protein phosphatase activity" EXACT []
xref: EC:3.1.3.16
xref: MetaCyc:3.1.3.16-RXN
xref: Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2"
xref: Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate"
xref: Reactome:R-HSA-163689 "Dephosphorylation of pChREBP (Ser 196) by PP2A"
xref: Reactome:R-HSA-163750 "Dephosphorylation of phosphoPFKFB1 by PP2A complex"
xref: Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin"
xref: Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT"
xref: Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A"
xref: Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34"
xref: Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A"
xref: Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3"
xref: Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3"
xref: Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1"
xref: Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1"
xref: Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex"
xref: Reactome:R-HSA-380949 "AMPK is dephosphorylated"
xref: Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1"
xref: Reactome:R-HSA-429730 "PPM1L dephosphorylates multiphospho-CERT1-2"
xref: Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN"
xref: Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1"
xref: Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs"
xref: Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1"
xref: Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338"
xref: Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P"
xref: Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1"
xref: Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2"
xref: Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6"
xref: Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH"
xref: Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24"
xref: Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2"
xref: Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma"
xref: Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO"
xref: Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5"
xref: Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4"
xref: Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII"
xref: Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"
xref: Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs"
xref: Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex"
xref: Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs"
xref: Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2"
xref: Reactome:R-HSA-9831948 "P:PP1 dephosphorylates M2-1"
xref: Reactome:R-HSA-9853385 "PPP1CC dephosphorylates PLK1"
xref: Reactome:R-HSA-9861725 "PGAM5 dodecamer dephosphorylates p-S336-ME1"
xref: Reactome:R-HSA-9865226 "PP2A dephosphorylates serine-127 of YAP1"
xref: Reactome:R-HSA-9865238 "PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin"
xref: Reactome:R-HSA-9912527 "H139Hfs13* PPM1K does not dephosphorylate BCKDH"
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0004723
name: calcium-dependent protein serine/threonine phosphatase activity
namespace: molecular_function
alt_id: GO:0008596
def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [GOC:mah]
synonym: "calcineurin" NARROW []
synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT []
xref: Reactome:R-HSA-2025882 "Calcineurin dephosphorylates NFATC1,2,3"
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0004725
name: protein tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
synonym: "[phosphotyrosine]protein phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" RELATED [EC:3.1.3.48]
synonym: "phosphotyrosine histone phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "phosphotyrosine phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "phosphotyrosine protein phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "phosphotyrosylprotein phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "PPT-phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "protein phosphotyrosine phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "protein-tyrosine-phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "protein-tyrosine-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.48]
synonym: "PTP-phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "PTPase activity" RELATED [EC:3.1.3.48]
synonym: "tyrosine O-phosphate phosphatase activity" RELATED [EC:3.1.3.48]
synonym: "tyrosylprotein phosphatase activity" RELATED [EC:3.1.3.48]
xref: EC:3.1.3.48
xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN
xref: Reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2"
xref: Reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR"
xref: Reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2"
xref: Reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2"
xref: Reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45"
xref: Reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)"
xref: Reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1"
xref: Reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases"
xref: Reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn"
xref: Reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)"
xref: Reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX"
xref: Reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET"
xref: Reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET"
xref: Reactome:R-HSA-74733 "Insulin receptor de-phosphorylation"
xref: Reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2"
xref: Reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1"
xref: Reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs"
xref: Reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6"
xref: Reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22"
xref: Reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70"
xref: Reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248"
xref: Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1172 (Y1148)"
xref: Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021"
xref: Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248"
xref: Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15"
xref: Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12"
xref: Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1"
xref: Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB"
xref: Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3"
xref: Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A"
xref: Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B"
xref: Reactome:R-HSA-9674816 "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS"
xref: Reactome:R-HSA-9698408 "PTPRJ dephosphorylates active FLT3"
xref: Reactome:R-HSA-9700200 "PTPRZ dephosphorylates ligand-bound ALK dimers"
xref: Reactome:R-HSA-9701507 "PTPN6 dephosphorylates JAK3"
xref: Reactome:R-HSA-9865167 "PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)"
xref: Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2"
xref: Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B"
xref: Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1"
xref: Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP"
xref: RHEA:10684
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0004726
name: non-membrane spanning protein tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [PMID:34353440]
xref: Reactome:R-HSA-177923 "Sustained activation of SRC kinase by SHP2"
xref: Reactome:R-HSA-177924 "Dephosphorylation of Gab1 by SHP2"
xref: Reactome:R-HSA-177926 "Dephosphorylation of PAG by SHP2"
xref: Reactome:R-HSA-177935 "SHP2 dephosphorylates Tyr 992 on EGFR"
xref: Reactome:R-HSA-9635739 "PTPN7 dephosphorylates p-T,Y-MAPKs"
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0004727
name: obsolete prenylated protein tyrosine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of protein tyrosine phosphatase activity ; GO:0004725.
is_obsolete: true
replaced_by: GO:0004725

[Term]
id: GO:0004728
name: obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
comment: This term was obsoleted because it was not clearly defined.
synonym: "receptor signaling protein tyrosine phosphatase activity" EXACT []
synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0004729
name: oxygen-dependent protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX." [RHEA:25576]
synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" RELATED [EC:1.3.3.4]
xref: EC:1.3.3.4
xref: KEGG_REACTION:R03222
xref: MetaCyc:PROTOPORGENOXI-RXN
xref: Reactome:R-HSA-189423 "PPO oxidises PPGEN9 to PRIN9"
xref: RHEA:25576
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
is_a: GO:0070818 ! protoporphyrinogen oxidase activity

[Term]
id: GO:0004730
name: pseudouridylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate." [EC:4.2.1.70, RHEA:18337]
comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine.
synonym: "5-ribosyluracil 5-phosphate synthetase activity" RELATED [EC:4.2.1.70]
synonym: "pseudouridine monophosphate synthase activity" EXACT []
synonym: "pseudouridine monophosphate synthetase activity" RELATED [EC:4.2.1.70]
synonym: "pseudouridine-5'-phosphate glycosidase activity" EXACT []
synonym: "pseudouridylate synthetase activity" RELATED [EC:4.2.1.70]
synonym: "pseudouridylic acid synthetase activity" RELATED [EC:4.2.1.70]
synonym: "psiUMP synthetase activity" RELATED [EC:4.2.1.70]
synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" RELATED [EC:4.2.1.70]
synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" RELATED [EC:4.2.1.70]
synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70]
xref: EC:4.2.1.70
xref: KEGG_REACTION:R01055
xref: MetaCyc:RXN0-5398
xref: RHEA:18337
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004731
name: purine-nucleoside phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1]
synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1]
synonym: "inosine-guanosine phosphorylase activity" RELATED [EC:2.4.2.1]
synonym: "PNPase activity" RELATED [EC:2.4.2.1]
synonym: "PUNPI" RELATED [EC:2.4.2.1]
synonym: "PUNPII" RELATED [EC:2.4.2.1]
synonym: "purine deoxynucleoside phosphorylase activity" RELATED [EC:2.4.2.1]
synonym: "purine deoxyribonucleoside phosphorylase activity" RELATED [EC:2.4.2.1]
synonym: "purine nucleoside phosphorylase activity" RELATED [EC:2.4.2.1]
synonym: "purine ribonucleoside phosphorylase activity" RELATED [EC:2.4.2.1]
synonym: "purine-nucleoside:phosphate ribosyltransferase activity" RELATED [EC:2.4.2.1]
xref: EC:2.4.2.1
xref: MetaCyc:PNP-RXN
xref: Reactome:R-HSA-112033 "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine"
xref: Reactome:R-HSA-112034 "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine"
xref: Reactome:R-HSA-74242 "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose"
xref: Reactome:R-HSA-74249 "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose"
xref: Reactome:R-HSA-9735775 "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose"
xref: Reactome:R-HSA-9735789 "Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose"
xref: Reactome:R-HSA-9755044 "PNP trimer transforms RBV to T-CONH2"
xref: RHEA:19805
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0004732
name: pyridoxal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction:  pyridoxal + H2O + O2 = 4-pyridoxate + H+ + H2O2." [RHEA:23724]
synonym: "pyridoxal:oxygen 4-oxidoreductase activity" RELATED [EC:1.2.3.8]
xref: EC:1.2.3.8
xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN
xref: RHEA:23724
is_a: GO:0004031 ! aldehyde oxidase activity

[Term]
id: GO:0004733
name: pyridoxamine phosphate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + hydrogen peroxide." [PMID:11786019]
synonym: "PMP oxidase activity" RELATED [EC:1.4.3.5]
synonym: "pyridoxal 5'-phosphate synthase activity" RELATED [EC:1.4.3.5]
synonym: "pyridoxamine 5'-phosphate oxidase activity" RELATED [EC:1.4.3.5]
synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.5]
synonym: "pyridoxamine-phosphate oxidase activity" RELATED [EC:1.4.3.5]
synonym: "pyridoxaminephosphate oxidase deaminating" RELATED [EC:1.4.3.5]
synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" RELATED [EC:1.4.3.5]
synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" RELATED [EC:1.4.3.5]
xref: EC:1.4.3.5
xref: MetaCyc:PMPOXI-RXN
xref: Reactome:R-HSA-965019 "2xPNPO:2xFMN oxidizes PDXP to PXLP"
xref: Reactome:R-HSA-965079 "2xPNPO:2xFMN oxidizes PXAP to PXLP"
xref: RHEA:15817
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0004734
name: pyrimidodiazepine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1]
synonym: "PDA synthase activity" RELATED [EC:1.5.4.1]
synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" RELATED [EC:1.5.4.1]
xref: EC:1.5.4.1
xref: MetaCyc:1.5.4.1-RXN
xref: RHEA:10720
is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor

[Term]
id: GO:0004735
name: pyrroline-5-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2]
synonym: "1-pyrroline-5-carboxylate reductase activity" RELATED [EC:1.5.1.2]
synonym: "L-proline oxidase activity" RELATED [EC:1.5.1.2]
synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" RELATED [EC:1.5.1.2]
synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" RELATED [EC:1.5.1.2]
synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" RELATED [EC:1.5.1.2]
synonym: "P5CR activity" RELATED [EC:1.5.1.2]
xref: EC:1.5.1.2
xref: MetaCyc:PYRROLINECARBREDUCT-RXN
xref: Reactome:R-HSA-6783939 "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro"
xref: Reactome:R-HSA-6783955 "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro"
xref: Reactome:R-HSA-70664 "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro"
xref: RHEA:14109
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004736
name: pyruvate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20844]
synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.1]
synonym: "pyruvic carboxylase activity" RELATED [EC:6.4.1.1]
xref: EC:6.4.1.1
xref: KEGG_REACTION:R00344
xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN
xref: Reactome:R-HSA-70501 "PC carboxylates PYR to OA"
xref: RHEA:20844
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0004737
name: pyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1]
synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" RELATED [EC:4.1.1.1]
synonym: "2-oxo-acid carboxy-lyase activity" RELATED [EC:4.1.1.1]
synonym: "alpha-carboxylase activity" RELATED [EC:4.1.1.1]
synonym: "alpha-ketoacid carboxylase activity" RELATED [EC:4.1.1.1]
synonym: "pyruvic decarboxylase activity" RELATED [EC:4.1.1.1]
xref: EC:4.1.1.1
xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN
xref: RHEA:11628
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004738
name: pyruvate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716720094]
synonym: "pyruvic acid dehydrogenase activity" RELATED [EC:1.2.4.1]
synonym: "pyruvic dehydrogenase activity" RELATED [EC:1.2.4.1]
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0004739
name: pyruvate dehydrogenase (acetyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1]
synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1]
synonym: "PDH" RELATED [EC:1.2.4.1]
synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT []
synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1]
synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" RELATED [EC:1.2.4.1]
synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" RELATED [EC:1.2.4.1]
xref: EC:1.2.4.1
xref: MetaCyc:RXN0-1134
xref: Reactome:R-HSA-9861734 "PDH E1 decarboxylates PYR, transferring acetyl to DLAT"
xref: RHEA:19189
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0004740
name: pyruvate dehydrogenase (acetyl-transferring) kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]." [RHEA:23052]
synonym: "PDH kinase activity" RELATED [EC:2.7.11.2]
synonym: "PDHK" RELATED [EC:2.7.11.2]
synonym: "PDK" RELATED [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase kinase activity" RELATED [EC:2.7.11.2]
xref: EC:2.7.11.2
xref: MetaCyc:2.7.11.2-RXN
xref: Reactome:R-HSA-203946 "PDK isozymes phosphorylate PDHC subunit E1"
xref: RHEA:23052
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004741
name: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity
namespace: molecular_function
alt_id: GO:0019906
def: "Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate." [EC:3.1.3.43]
synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase activity" EXACT []
synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT []
synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT []
xref: EC:3.1.3.43
xref: MetaCyc:3.1.3.43-RXN
xref: Reactome:R-HSA-204169 "PDP1,2 dephosphorylate p-lipo-PDH"
xref: RHEA:12669
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0004742
name: dihydrolipoyllysine-residue acetyltransferase activity
namespace: molecular_function
alt_id: GO:0030523
def: "Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA." [RHEA:17017]
synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT []
synonym: "dihydrolipoamide S-acyltransferase activity" RELATED []
synonym: "dihydrolipoate acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "dihydrolipoic transacetylase activity" RELATED [EC:2.3.1.12]
synonym: "dihydrolipoyl acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "lipoate acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "lipoate transacetylase activity" RELATED [EC:2.3.1.12]
synonym: "lipoic acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "lipoic acid acetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "lipoic transacetylase activity" RELATED [EC:2.3.1.12]
synonym: "lipoylacetyltransferase activity" RELATED [EC:2.3.1.12]
synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12]
synonym: "transacetylase X activity" NARROW [EC:2.3.1.12]
xref: EC:2.3.1.12
xref: Reactome:R-HSA-9861667 "DLAT trimer transfers acetyl to CoA"
xref: RHEA:17017
is_a: GO:0016418 ! S-acetyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004743
name: pyruvate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate." [EC:2.7.1.40, RHEA:18159]
synonym: "ATP:pyruvate 2-O-phosphotransferase activity" RELATED [EC:2.7.1.40]
synonym: "phosphoenol transphosphorylase activity" RELATED [EC:2.7.1.40]
synonym: "phosphoenolpyruvate kinase activity" RELATED [EC:2.7.1.40]
xref: EC:2.7.1.40
xref: MetaCyc:PEPDEPHOS-RXN
xref: Reactome:R-HSA-71670 "PKM dephosphorylates PEP to PYR"
xref: RHEA:18159
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004744
name: obsolete retinal isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [PMID:21447403]
comment: The Enzyme Commission has deleted the EC correspondingj to this term because it is now known to be catalysed by a pathway involving multiple enzymes.
synonym: "all-trans-retinal 11-cis-trans-isomerase activity" RELATED []
synonym: "retinene isomerase activity" RELATED []
synonym: "retinoid isomerase activity" BROAD []
is_obsolete: true
consider: GO:0106434

[Term]
id: GO:0004745
name: all-trans-retinol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form." [RHEA:48488]
synonym: "all-trans retinol dehydrogenase activity" BROAD [EC:1.1.1.105]
synonym: "retinal reductase activity" BROAD [GOC:ecd, PMID:12036956]
synonym: "retinene reductase activity" BROAD [EC:1.1.1.105]
synonym: "retinol (vitamin A1) dehydrogenase activity" BROAD [EC:1.1.1.105]
synonym: "retinol dehydrogenase activity" BROAD []
xref: EC:1.1.1.105
xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL"
xref: Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA"
xref: Reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL"
xref: Reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro"
xref: Reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL"
xref: RHEA:48488
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0004746
name: riboflavin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin." [EC:2.5.1.9, RHEA:20772]
synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" RELATED [EC:2.5.1.9]
synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9]
synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9]
synonym: "riboflavin synthetase activity" RELATED [EC:2.5.1.9]
synonym: "riboflavine synthase activity" RELATED [EC:2.5.1.9]
synonym: "riboflavine synthetase activity" RELATED [EC:2.5.1.9]
synonym: "vitamin B2 synthase activity" EXACT []
xref: EC:2.5.1.9
xref: KEGG_REACTION:R00066
xref: MetaCyc:RIBOFLAVIN-SYN-RXN
xref: RHEA:20772
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004747
name: ribokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15]
synonym: "ATP:D-ribose 5-phosphotransferase activity" RELATED [EC:2.7.1.15]
synonym: "D-ribokinase activity" RELATED [EC:2.7.1.15]
synonym: "deoxyribokinase activity" RELATED [EC:2.7.1.15]
synonym: "ribokinase (phosphorylating)" RELATED [EC:2.7.1.15]
xref: EC:2.7.1.15
xref: MetaCyc:RIBOKIN-RXN
xref: Reactome:R-HSA-8955844 "RBKS phosphorylates ribose to R5P"
xref: RHEA:13697
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004748
name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
namespace: molecular_function
alt_id: GO:0016959
alt_id: GO:0016960
alt_id: GO:0016961
def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]
comment: When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'.
synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" RELATED [EC:1.17.4.1]
synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" RELATED [EC:1.17.4.1]
xref: EC:1.17.4.1
xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN
xref: Reactome:R-HSA-111751 "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)"
xref: Reactome:R-HSA-111804 "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)"
xref: RHEA:23252
is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0004749
name: ribose phosphate diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+." [RHEA:15609]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "5-phosphoribose pyrophosphorylase activity" RELATED [EC:2.7.6.1]
synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" RELATED [EC:2.7.6.1]
synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" RELATED [EC:2.7.6.1]
synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" RELATED [EC:2.7.6.1]
synonym: "phosphoribosyl diphosphate synthetase activity" RELATED [EC:2.7.6.1]
synonym: "phosphoribosyl pyrophosphate synthetase activity" RELATED [EC:2.7.6.1]
synonym: "phosphoribosyl-diphosphate synthetase activity" RELATED [EC:2.7.6.1]
synonym: "phosphoribosylpyrophosphate synthase activity" RELATED [EC:2.7.6.1]
synonym: "phosphoribosylpyrophosphate synthetase activity" RELATED [EC:2.7.6.1]
synonym: "PP-ribose P synthetase activity" RELATED [EC:2.7.6.1]
synonym: "PPRibP synthetase activity" RELATED [EC:2.7.6.1]
synonym: "PRPP synthetase activity" RELATED [EC:2.7.6.1]
synonym: "pyrophosphoribosylphosphate synthetase activity" RELATED [EC:2.7.6.1]
synonym: "ribophosphate pyrophosphokinase activity" RELATED [EC:2.7.6.1]
synonym: "ribose-5-phosphate pyrophosphokinase activity" RELATED [EC:2.7.6.1]
synonym: "ribose-phosphate diphosphokinase activity" RELATED [EC:2.7.6.1]
synonym: "ribose-phosphate pyrophosphokinase activity" EXACT []
xref: EC:2.7.6.1
xref: KEGG_REACTION:R01049
xref: MetaCyc:PRPPSYN-RXN
xref: Reactome:R-HSA-111215 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate"
xref: Reactome:R-HSA-73580 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate"
xref: RHEA:15609
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0004750
name: D-ribulose-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13677]
synonym: "D-ribulose 5-phosphate epimerase activity" RELATED [EC:5.1.3.1]
synonym: "D-ribulose phosphate-3-epimerase activity" RELATED [EC:5.1.3.1]
synonym: "D-ribulose-5-P 3-epimerase activity" RELATED [EC:5.1.3.1]
synonym: "D-ribulose-5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1]
synonym: "D-ribulose-5-phosphate epimerase activity" RELATED [EC:5.1.3.1]
synonym: "D-xylulose-5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1]
synonym: "erythrose-4-phosphate epimerase activity" RELATED [EC:5.1.3.1]
synonym: "erythrose-4-phosphate isomerase activity" RELATED [EC:5.1.3.1]
synonym: "pentose phosphate epimerase (PPE)" RELATED [PMID:9872416]
synonym: "pentose-5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1]
synonym: "phosphoketopentose 3-epimerase activity" RELATED [EC:5.1.3.1]
synonym: "phosphoketopentose epimerase activity" RELATED [EC:5.1.3.1]
synonym: "phosphoribulose epimerase activity" RELATED [EC:5.1.3.1]
synonym: "ribulose 5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1]
synonym: "ribulose-phosphate 3-epimerase activity" RELATED []
synonym: "xylulose phosphate 3-epimerase activity" RELATED [EC:5.1.3.1]
xref: EC:5.1.3.1
xref: KEGG_REACTION:R01529
xref: MetaCyc:RIBULP3EPIM-RXN
xref: Reactome:R-HSA-199803 "xylulose 5-phosphate <=> D-ribulose 5-phosphate"
xref: Reactome:R-HSA-71303 "RPE dimers isomerise RU5P to XY5P"
xref: RHEA:13677
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0004751
name: ribose-5-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate." [RHEA:14657]
synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6]
synonym: "pentose phosphate isomerase (PPI)" EXACT []
synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6]
synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6]
synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6]
xref: EC:5.3.1.6
xref: KEGG_REACTION:R01056
xref: MetaCyc:RIB5PISOM-RXN
xref: Reactome:R-HSA-177784 "ribose 5-phosphate <=> D-ribulose 5-phosphate"
xref: Reactome:R-HSA-5660013 "Defective RPIA does not isomerize RU5P to R5P"
xref: Reactome:R-HSA-5660015 "Defective RPIA does not isomerize R5P to RU5P"
xref: Reactome:R-HSA-71306 "D-ribulose 5-phosphate <=> ribose 5-phosphate"
xref: RHEA:14657
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004753
name: saccharopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah]
synonym: "lysine-2-oxoglutarate reductase activity" RELATED []
synonym: "lysine-ketoglutarate reductase activity" RELATED []
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004754
name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH." [EC:1.5.1.7, RHEA:12440]
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.7]
synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" RELATED [EC:1.5.1.7]
synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" RELATED [EC:1.5.1.7]
synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.7]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.7]
xref: EC:1.5.1.7
xref: KEGG_REACTION:R00715
xref: MetaCyc:1.5.1.7-RXN
xref: RHEA:12440
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0004755
name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + H2O + NADP+ = L-allysine + L-glutamate + H+ + NADPH." [EC:1.5.1.10, RHEA:10020]
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.10]
synonym: "aminoadipate semialdehyde-glutamate reductase activity" RELATED [EC:1.5.1.10]
synonym: "aminoadipic semialdehyde-glutamate reductase activity" RELATED [EC:1.5.1.10]
synonym: "aminoadipic semialdehyde-glutamic reductase activity" RELATED [EC:1.5.1.10]
synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" RELATED [EC:1.5.1.10]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.10]
synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" RELATED [EC:1.5.1.10]
synonym: "saccharopine reductase activity" RELATED [EC:1.5.1.10]
xref: EC:1.5.1.10
xref: KEGG_REACTION:R02315
xref: MetaCyc:RXN3O-127
xref: RHEA:10020
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0004756
name: selenide, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18737]
synonym: "ATP:selenide, water phosphotransferase activity" RELATED [EC:2.7.9.3]
synonym: "selenide,water dikinase activity" RELATED [EC:2.7.9.3]
synonym: "selenium donor protein activity" RELATED [EC:2.7.9.3]
synonym: "selenophosphate synthase activity" EXACT []
synonym: "selenophosphate synthetase activity" RELATED [EC:2.7.9.3]
xref: EC:2.7.9.3
xref: KEGG_REACTION:R03595
xref: MetaCyc:2.7.9.3-RXN
xref: Reactome:R-HSA-8959510 "SEPHS2 phosphorylates H2Se to form SELP"
xref: RHEA:18737
xref: UM-BBD_reactionID:r0833
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0004757
name: sepiapterin reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reactions: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H+ + 2 NADPH." [EC:1.1.1.153]
synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.153]
xref: EC:1.1.1.153
xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN
xref: Reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)"
xref: Reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to q-BH2"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004758
name: serine C-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA." [EC:2.3.1.50, RHEA:14761]
synonym: "3-oxosphinganine synthetase activity" RELATED [EC:2.3.1.50]
synonym: "serine palmitoyltransferase" BROAD []
synonym: "SPT" RELATED [EC:2.3.1.50]
xref: EC:2.3.1.50
xref: KEGG_REACTION:R01281
xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN
xref: Reactome:R-HSA-428127 "SPTLC complexes transfer acyl-CoA onto serine"
xref: RHEA:14761
is_a: GO:0016454 ! C-palmitoyltransferase activity

[Term]
id: GO:0004760
name: L-serine-pyruvate transaminase activity
namespace: molecular_function
alt_id: GO:0004761
alt_id: GO:0004762
alt_id: GO:0004763
def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22852]
synonym: "hydroxypyruvate:L-alanine transaminase activity" RELATED [EC:2.6.1.51]
synonym: "L-serine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.51]
synonym: "serine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.51]
synonym: "serine-pyruvate aminotransferase activity" EXACT []
synonym: "serine-pyruvate aminotransferase, type 1" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2A" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2B" NARROW []
synonym: "SPT" RELATED [EC:2.6.1.51]
xref: EC:2.6.1.51
xref: KEGG_REACTION:R00585
xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN
xref: RHEA:22852
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004764
name: shikimate 3-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+." [EC:1.1.1.25]
synonym: "5-dehydroshikimate reductase activity" RELATED [EC:1.1.1.25]
synonym: "5-dehydroshikimic reductase activity" RELATED [EC:1.1.1.25]
synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25]
synonym: "DHS reductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate:NADP(+) 5-oxidoreductase activity" RELATED [EC:1.1.1.25]
synonym: "shikimate:NADP(+) oxidoreductase activity" BROAD [EC:1.1.1.25]
xref: EC:1.1.1.25
xref: KEGG_REACTION:R02413
xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN
xref: RHEA:17737
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004765
name: shikimate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+." [EC:2.7.1.71, RHEA:13121]
synonym: "ATP:shikimate 3-phosphotransferase activity" RELATED [EC:2.7.1.71]
synonym: "shikimate kinase (phosphorylating)" RELATED [EC:2.7.1.71]
synonym: "shikimate kinase II" RELATED [EC:2.7.1.71]
xref: EC:2.7.1.71
xref: KEGG_REACTION:R02412
xref: MetaCyc:SHIKIMATE-KINASE-RXN
xref: RHEA:13121
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004766
name: spermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16]
synonym: "aminopropyltransferase activity" RELATED [EC:2.5.1.16]
synonym: "putrescine aminopropyltransferase activity" RELATED [EC:2.5.1.16]
synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" RELATED [EC:2.5.1.16]
synonym: "SpeE" RELATED [EC:2.5.1.16]
synonym: "spermidine synthetase activity" RELATED [EC:2.5.1.16]
xref: EC:2.5.1.16
xref: MetaCyc:SPERMIDINESYN-RXN
xref: Reactome:R-HSA-351215 "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine"
xref: RHEA:12721
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004767
name: sphingomyelin phosphodiesterase activity
namespace: molecular_function
alt_id: GO:0030230
alt_id: GO:0030231
def: "Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+." [EC:3.1.4.12, RHEA:19253]
subset: goslim_chembl
synonym: "sphingomyelin cholinephosphohydrolase activity" RELATED [EC:3.1.4.12]
synonym: "sphingomyelinase activity" EXACT []
xref: EC:3.1.4.12
xref: KEGG_REACTION:R02541
xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
xref: Reactome:R-HSA-1605797 "SMPD1 hydrolyzes SPHM"
xref: Reactome:R-HSA-1606273 "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)"
xref: Reactome:R-HSA-1606288 "SMPD4 hydrolyzes sphingomyelin (ER membrane)"
xref: Reactome:R-HSA-1640164 "ENPP7 hydrolyzes sphingomyelin"
xref: Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets"
xref: RHEA:19253
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004768
name: stearoyl-CoA 9-desaturase activity
namespace: molecular_function
alt_id: GO:0016214
alt_id: GO:0043735
def: "Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." [RHEA:19721]
synonym: "acyl-CoA desaturase" BROAD [EC:1.14.19.1]
synonym: "delta(9)-desaturase activity" BROAD [EC:1.14.19.1]
synonym: "delta9-desaturase" BROAD [EC:1.14.19.1]
synonym: "fatty acid desaturase" BROAD [EC:1.14.19.1]
synonym: "stearoyl-CoA desaturase activity" BROAD []
xref: EC:1.14.19.1
xref: MetaCyc:1.14.19.1-RXN
xref: Reactome:R-HSA-5690565 "SCD desaturates ST-CoA to OLE-CoA"
xref: Reactome:R-HSA-8847579 "SCD5 desaturates ST-CoA to OLE-CoA"
xref: RHEA:19721
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0004769
name: steroid Delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [RHEA:14709]
synonym: "3-oxosteroid delta5-delta4-isomerase activity" RELATED [EC:5.3.3.1]
synonym: "3-oxosteroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta(5)-3-keto steroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta(5)-3-ketosteroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta(5)-3-oxosteroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta(5)-steroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta5(or delta4)-3-keto steroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta5-3-keto steroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta5-3-ketosteroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta5-3-oxosteroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta5-ketosteroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "delta5-steroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "hydroxysteroid isomerase activity" RELATED [EC:5.3.3.1]
synonym: "steroid D-isomerase activity" EXACT []
synonym: "steroid isomerase activity" RELATED [EC:5.3.3.1]
xref: EC:5.3.3.1
xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN
xref: Reactome:R-HSA-193052 "Pregn-5-ene-3,20-dione isomerizes to progesterone"
xref: Reactome:R-HSA-193073 "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST"
xref: Reactome:R-HSA-193961 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone"
xref: Reactome:R-HSA-195690 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol"
xref: Reactome:R-HSA-6807052 "EBP isomerizes ZYMSTNL to LTHSOL"
xref: RHEA:14709
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004771
name: sterol ester esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a sterol ester + H2O = a fatty acid + a sterol + H+." [RHEA:10100]
subset: goslim_chembl
synonym: "acylcholesterol lipase activity" RELATED [EC:3.1.1.13]
synonym: "cholesterase activity" RELATED [EC:3.1.1.13]
synonym: "cholesterol ester hydrolase activity" RELATED [EC:3.1.1.13]
synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13]
synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13]
synonym: "cholesteryl ester hydrolase activity" RELATED [EC:3.1.1.13]
synonym: "cholesteryl ester synthase activity" RELATED [EC:3.1.1.13]
synonym: "cholesteryl esterase activity" RELATED [EC:3.1.1.13]
synonym: "sterol ester hydrolase activity" RELATED [EC:3.1.1.13]
synonym: "sterol esterase activity" EXACT []
synonym: "steryl-ester acylhydrolase activity" RELATED [EC:3.1.1.13]
synonym: "triterpenol esterase activity" RELATED [EC:3.1.1.13]
xref: EC:3.1.1.13
xref: MetaCyc:STEROL-ESTERASE-RXN
xref: Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)"
xref: Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters"
xref: Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids"
xref: RHEA:10100
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0004772
name: sterol O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0017066
def: "Catalysis of the reaction: a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA." [RHEA:59816]
synonym: "sterol-ester synthase activity" RELATED [EC:2.3.1.26]
synonym: "sterol-ester synthetase activity" RELATED [EC:2.3.1.26]
xref: EC:2.3.1.26
xref: MetaCyc:RXN-20233
xref: RHEA:59816
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004773
name: steryl-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate." [EC:3.1.6.2]
synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "arylsulfatase C activity" RELATED [EC:3.1.6.2]
synonym: "dehydroepiandrosterone sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "dehydroepiandrosterone sulfate sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "phenolic steroid sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "pregnenolone sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "steroid 3-sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "steroid sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "steroid sulfate sulfohydrolase activity" RELATED [EC:3.1.6.2]
synonym: "sterol sulfatase activity" RELATED [EC:3.1.6.2]
synonym: "steryl-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.2]
synonym: "steryl-sulphatase activity" EXACT []
xref: EC:3.1.6.2
xref: MetaCyc:STERYL-SULFATASE-RXN
xref: Reactome:R-HSA-1606839 "ARSC hydrolyzes steroid sulfates"
xref: RHEA:19873
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004774
name: succinate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [GOC:ai]
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0004775
name: succinate-CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [PMID:9874242, RHEA:17661]
synonym: "succinate thiokinase activity" RELATED [EC:6.2.1.5]
synonym: "succinic thiokinase" BROAD []
synonym: "succinyl coenzyme A synthetase" BROAD []
synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" RELATED []
synonym: "succinyl-CoA synthetase (ADP-forming) activity" RELATED [EC:6.2.1.5]
synonym: "succinyl-CoA synthetase activity" RELATED []
xref: EC:6.2.1.5
xref: KEGG_REACTION:R00405
xref: MetaCyc:SUCCCOASYN-RXN
xref: Reactome:R-HSA-70997 "SUCLG1/A2 cleaves succinyl-CoA"
xref: RHEA:17661
is_a: GO:0004774 ! succinate-CoA ligase activity

[Term]
id: GO:0004776
name: succinate-CoA ligase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [RHEA:22120]
synonym: "succinate:CoA ligase (GDP-forming) activity" RELATED [EC:6.2.1.4]
synonym: "succinyl CoA synthetase activity" RELATED []
synonym: "succinyl coenzyme A synthetase" BROAD []
synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" RELATED []
synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" RELATED []
synonym: "succinyl-CoA synthetase (GDP-forming) activity" RELATED []
xref: EC:6.2.1.4
xref: KEGG_REACTION:R00432
xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN
xref: Reactome:R-HSA-71775 "SUCLG1/G2 cleaves succinyl-CoA"
xref: RHEA:22120
is_a: GO:0004774 ! succinate-CoA ligase activity

[Term]
id: GO:0004777
name: succinate-semialdehyde dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0008952
def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [RHEA:13217]
synonym: "succinate semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24]
synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.24]
synonym: "succinate-semialdehyde dehydrogenase activity" BROAD [GOC:bf]
synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.24]
synonym: "succinic semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24]
synonym: "succinyl semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.24]
xref: EC:1.2.1.24
xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-888548 "ALDH5A1 dehydrogenates SUCCSA to SUCCA"
xref: RHEA:13217
is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0004778
name: succinyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate." [EC:3.1.2.3, RHEA:11516]
synonym: "succinyl coenzyme A deacylase activity" RELATED [EC:3.1.2.3]
synonym: "succinyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.3]
synonym: "succinyl-CoA acylase activity" RELATED [EC:3.1.2.3]
xref: EC:3.1.2.3
xref: KEGG_REACTION:R00407
xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN
xref: RHEA:11516
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0004779
name: sulfate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah]
synonym: "sulphate adenylyltransferase activity" EXACT []
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004780
name: sulfate adenylyltransferase (ADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H+ + sulfate = 5'-adenylyl sulfate + phosphate." [EC:2.7.7.5, RHEA:16529]
synonym: "adenosine diphosphate sulfurylase activity" RELATED [EC:2.7.7.5]
synonym: "ADP-sulfurylase activity" RELATED [EC:2.7.7.5]
synonym: "ADP:sulfate adenylyltransferase activity" EXACT []
synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" RELATED [EC:2.7.7.5]
synonym: "sulphate adenylyltransferase (ADP) activity" EXACT []
xref: EC:2.7.7.5
xref: KEGG_REACTION:R00530
xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN
xref: RHEA:16529
is_a: GO:0004779 ! sulfate adenylyltransferase activity

[Term]
id: GO:0004781
name: sulfate adenylyltransferase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H+ + sulfate = adenosine 5'-phosphosulfate + diphosphate." [EC:2.7.7.4]
synonym: "adenosine-5'-triphosphate sulfurylase activity" RELATED [EC:2.7.7.4]
synonym: "adenosinetriphosphate sulfurylase activity" RELATED [EC:2.7.7.4]
synonym: "adenylylsulfate pyrophosphorylase activity" RELATED [EC:2.7.7.4]
synonym: "ATP sulfurylase activity" RELATED [EC:2.7.7.4]
synonym: "ATP-sulfurylase activity" RELATED [EC:2.7.7.4]
synonym: "ATP:sulfate adenylyltransferase activity" EXACT []
synonym: "sulfate adenylate transferase activity" RELATED [EC:2.7.7.4]
synonym: "sulfurylase activity" RELATED [EC:2.7.7.4]
synonym: "sulphate adenylyltransferase (ATP) activity" EXACT []
xref: EC:2.7.7.4
xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN
xref: Reactome:R-HSA-174392 "PAPSS1,2 transfer SO4(2-) group to ATP to form APS"
xref: Reactome:R-HSA-3560794 "Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS"
xref: RHEA:18133
is_a: GO:0004779 ! sulfate adenylyltransferase activity

[Term]
id: GO:0004782
name: sulfinoalanine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29]
synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" RELATED [EC:4.1.1.29]
synonym: "3-sulfino-L-alanine carboxy-lyase activity" RELATED [EC:4.1.1.29]
synonym: "CADCase/CSADCase activity" RELATED [EC:4.1.1.29]
synonym: "CSAD" RELATED [EC:4.1.1.29]
synonym: "CSADCase activity" RELATED [EC:4.1.1.29]
synonym: "cysteic decarboxylase activity" RELATED [EC:4.1.1.29]
synonym: "cysteine-sulfinate decarboxylase activity" RELATED [EC:4.1.1.29]
synonym: "cysteinesulfinate decarboxylase activity" RELATED [EC:4.1.1.29]
synonym: "cysteinesulfinic acid decarboxylase activity" RELATED [EC:4.1.1.29]
synonym: "L-cysteinesulfinic acid decarboxylase activity" RELATED [EC:4.1.1.29]
synonym: "sulfoalanine decarboxylase activity" RELATED [EC:4.1.1.29]
synonym: "sulphinoalanine decarboxylase activity" EXACT []
xref: EC:4.1.1.29
xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN
xref: Reactome:R-HSA-1655443 "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine"
xref: RHEA:16877
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004783
name: sulfite reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [RHEA:13801]
synonym: "H2S-NADP oxidoreductase activity" RELATED [EC:1.8.1.2]
synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.2]
synonym: "NADPH-dependent sulfite reductase activity" RELATED [EC:1.8.1.2]
synonym: "NADPH-sulfite reductase activity" RELATED [EC:1.8.1.2]
synonym: "NADPH:sulfite reductase flavoprotein" RELATED []
synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.8.1.2]
synonym: "sulphite reductase (NADPH) activity" EXACT []
xref: EC:1.8.1.2
xref: MetaCyc:SULFITE-REDUCT-RXN
xref: RHEA:13801
is_a: GO:0016002 ! sulfite reductase activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0004784
name: superoxide dismutase activity
namespace: molecular_function
alt_id: GO:0004785
alt_id: GO:0008382
alt_id: GO:0008383
alt_id: GO:0016954
def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
synonym: "copper, zinc superoxide dismutase activity" NARROW []
synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1]
synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1]
synonym: "cuprein" RELATED [EC:1.15.1.1]
synonym: "cytocuprein" RELATED [EC:1.15.1.1]
synonym: "erythrocuprein" RELATED [EC:1.15.1.1]
synonym: "Fe-SOD" RELATED [EC:1.15.1.1]
synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1]
synonym: "hemocuprein" RELATED [EC:1.15.1.1]
synonym: "hepatocuprein" RELATED [EC:1.15.1.1]
synonym: "iron superoxide dismutase activity" NARROW []
synonym: "iron superoxide oxidoreductase" RELATED []
synonym: "manganese superoxide dismutase activity" NARROW []
synonym: "manganese superoxide oxidoreductase" RELATED []
synonym: "Mn, Fe superoxide dismutase" NARROW []
synonym: "Mn-SOD" RELATED [EC:1.15.1.1]
synonym: "nickel superoxide dismutase activity" NARROW []
synonym: "nickel superoxide oxidoreductase" RELATED []
synonym: "SOD" RELATED [EC:1.15.1.1]
synonym: "SOD-1" RELATED [EC:1.15.1.1]
synonym: "SOD-2" RELATED [EC:1.15.1.1]
synonym: "SOD-3" RELATED [EC:1.15.1.1]
synonym: "SOD-4" RELATED [EC:1.15.1.1]
synonym: "SODF" RELATED [EC:1.15.1.1]
synonym: "SODS" RELATED [EC:1.15.1.1]
synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1]
synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1]
synonym: "superoxide:superoxide oxidoreductase activity" EXACT []
synonym: "zinc superoxide oxidoreductase" RELATED []
xref: EC:1.15.1.1
xref: MetaCyc:SUPEROX-DISMUT-RXN
xref: Reactome:R-HSA-1222462 "SodB reduces superoxide to H2O2"
xref: Reactome:R-HSA-1222469 "SodC reduces superoxide to H2O2"
xref: Reactome:R-HSA-3299680 "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)"
xref: Reactome:R-HSA-3299682 "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)"
xref: Reactome:R-HSA-3299691 "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)"
xref: Reactome:R-HSA-3777112 "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)"
xref: RHEA:20696
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0004786
name: obsolete Mn, Fe superoxide dismutase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the function is covered by an existing term.
synonym: "Mn, Fe superoxide dismutase" EXACT []
is_obsolete: true
consider: GO:0004784

[Term]
id: GO:0004787
name: thiamine diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate." [GOC:ai, RHEA:27998]
synonym: "thiamin pyrophosphatase activity" EXACT []
synonym: "thiamin-pyrophosphatase activity" EXACT []
synonym: "thiamine diphosphatase activity" BROAD []
synonym: "thiamine pyrophosphatase activity" EXACT []
synonym: "thiamine-diphosphatase activity" EXACT []
synonym: "thiaminpyrophosphatase activity" RELATED []
synonym: "TPPase activity" EXACT []
xref: RHEA:27998
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004788
name: thiamine diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [RHEA:11576]
synonym: "ATP:thiamin pyrophosphotransferase activity" RELATED [EC:2.7.6.2]
synonym: "ATP:thiamine diphosphotransferase activity" RELATED [EC:2.7.6.2]
synonym: "thiamin diphosphokinase activity" EXACT []
synonym: "thiamin pyrophosphokinase activity" EXACT []
synonym: "thiamin pyrophosphotransferase activity" RELATED [EC:2.7.6.2]
synonym: "thiamin:ATP pyrophosphotransferase activity" RELATED [EC:2.7.6.2]
synonym: "thiamine pyrophosphokinase activity" EXACT []
synonym: "thiaminokinase activity" RELATED [EC:2.7.6.2]
synonym: "TPTase activity" RELATED [EC:2.7.6.2]
xref: EC:2.7.6.2
xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN
xref: Reactome:R-HSA-196761 "2xTPK1:Mg2+ phosphorylates THMN"
xref: RHEA:11576
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0004789
name: thiamine-phosphate diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22328]
synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" RELATED [EC:2.5.1.3]
synonym: "thiamin-phosphate diphosphorylase activity" EXACT []
synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT []
synonym: "thiamine monophosphate pyrophosphorylase activity" RELATED [EC:2.5.1.3]
synonym: "thiamine phosphate pyrophosphorylase activity" RELATED [EC:2.5.1.3]
synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT []
synonym: "thiamine-phosphate synthase activity" RELATED [EC:2.5.1.3]
synonym: "TMP diphosphorylase activity" RELATED [EC:2.5.1.3]
synonym: "TMP pyrophosphorylase activity" RELATED [EC:2.5.1.3]
synonym: "TMP-PPase activity" RELATED [EC:2.5.1.3]
xref: EC:2.5.1.3
xref: KEGG_REACTION:R03223
xref: MetaCyc:THI-P-SYN-RXN
xref: RHEA:22328
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004790
name: thioether S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96, RHEA:19613]
synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" RELATED [EC:2.1.1.96]
synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" RELATED [EC:2.1.1.96]
synonym: "thioether methyltransferase activity" RELATED [EC:2.1.1.96]
xref: EC:2.1.1.96
xref: KEGG_REACTION:R02572
xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN
xref: RHEA:19613
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004791
name: thioredoxin-disulfide reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]
synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9]
synonym: "thioredoxin disulfide reductase activity" BROAD []
synonym: "thioredoxin reductase (NADPH) activity" EXACT []
synonym: "thioredoxin-disulfide reductase (NADP) activity" EXACT []
synonym: "thioredoxin-disulfide reductase activity" BROAD []
synonym: "thioredoxin-disulphide reductase activity" BROAD []
xref: EC:1.8.1.9
xref: KEGG_REACTION:R02016
xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN
xref: Reactome:R-HSA-1222485 "TrxB reactivates TrxA"
xref: Reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH"
xref: Reactome:R-HSA-73646 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+"
xref: Reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300"
xref: RHEA:20345
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0047134 ! protein-disulfide reductase (NAD(P)H) activity

[Term]
id: GO:0004792
name: thiosulfate sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16881]
synonym: "rhodanase activity" RELATED [EC:2.8.1.1]
synonym: "rhodanese activity" RELATED [EC:2.8.1.1]
synonym: "thiosulfate cyanide transsulfurase activity" RELATED [EC:2.8.1.1]
synonym: "thiosulfate thiotransferase activity" RELATED [EC:2.8.1.1]
synonym: "thiosulfate:cyanide sulfurtransferase activity" RELATED [EC:2.8.1.1]
synonym: "thiosulphate sulphurtransferase activity" EXACT []
xref: EC:2.8.1.1
xref: KEGG_REACTION:R01931
xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN
xref: Reactome:R-HSA-9013198 "TST transfers sulfur from S2O3(2-) to HCN to form HSCN"
xref: RHEA:16881
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0004793
name: threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5]
synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" RELATED [EC:4.1.2.5]
synonym: "L-threonine acetaldehyde-lyase activity" RELATED [EC:4.1.2.5]
synonym: "L-threonine aldolase activity" EXACT []
xref: EC:4.1.2.5
xref: MetaCyc:THREONINE-ALDOLASE-RXN
xref: RHEA:19625
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004794
name: threonine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4." [EC:4.3.1.19]
synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19]
synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19]
synonym: "L-threonine ammonia-lyase activity" EXACT []
synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19]
synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19]
synonym: "L-threonine hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.19]
synonym: "serine deaminase activity" RELATED [EC:4.3.1.19]
synonym: "threonine ammonia-lyase activity" BROAD []
synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19]
synonym: "threonine dehydratase activity" BROAD []
xref: EC:4.3.1.19
xref: MetaCyc:THREDEHYD-RXN
xref: RHEA:22108
xref: UM-BBD_reactionID:r0433
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0004795
name: threonine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1]
synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" RELATED [EC:4.2.3.1]
synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" RELATED [EC:4.2.3.1]
synonym: "threonine synthetase activity" RELATED [EC:4.2.3.1]
xref: EC:4.2.3.1
xref: MetaCyc:THRESYN-RXN
xref: RHEA:10840
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0004796
name: thromboxane-A synthase activity
namespace: molecular_function
alt_id: GO:0008400
def: "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17137]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" RELATED [EC:5.3.99.5]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" RELATED [EC:5.3.99.5]
synonym: "cytochrome P450 CYP5" NARROW []
synonym: "thromboxane synthase activity" RELATED [EC:5.3.99.5]
synonym: "thromboxane synthetase activity" RELATED [EC:5.3.99.5]
xref: EC:5.3.99.5
xref: KEGG_REACTION:R02268
xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN
xref: Reactome:R-HSA-5603275 "Defective TBXAS1 does not isomerise PGH2 to TXA2"
xref: Reactome:R-HSA-76500 "TBXAS1 isomerises PGH2 to TXA2"
xref: RHEA:17137
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0004797
name: thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21]
synonym: "2'-deoxythymidine kinase activity" RELATED [EC:2.7.1.21]
synonym: "ATP:thymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.21]
synonym: "deoxythymidine kinase (phosphorylating)" RELATED [EC:2.7.1.21]
synonym: "thymidine kinase (phosphorylating)" RELATED [EC:2.7.1.21]
xref: EC:2.7.1.21
xref: MetaCyc:THYKI-RXN
xref: RHEA:19129
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004798
name: thymidylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9]
synonym: "ATP:dTMP phosphotransferase activity" RELATED [EC:2.7.4.9]
synonym: "deoxythymidine 5'-monophosphate kinase activity" RELATED [EC:2.7.4.9]
synonym: "dTMP kinase activity" EXACT []
synonym: "thymidine 5'-monophosphate kinase activity" RELATED [EC:2.7.4.9]
synonym: "thymidine monophosphate kinase activity" RELATED [EC:2.7.4.9]
synonym: "thymidylate monophosphate kinase activity" RELATED [EC:2.7.4.9]
synonym: "thymidylic acid kinase activity" RELATED [EC:2.7.4.9]
synonym: "thymidylic kinase activity" RELATED [EC:2.7.4.9]
synonym: "TMPK activity" RELATED [EC:2.7.4.9]
xref: EC:2.7.4.9
xref: MetaCyc:DTMPKI-RXN
xref: RHEA:13517
is_a: GO:0050145 ! nucleoside monophosphate kinase activity

[Term]
id: GO:0004799
name: thymidylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12104]
synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" RELATED [EC:2.1.1.45]
synonym: "dTMP synthase activity" RELATED [EC:2.1.1.45]
synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" RELATED [EC:2.1.1.45]
synonym: "thymidylate synthetase activity" RELATED [EC:2.1.1.45]
synonym: "TMP synthetase activity" RELATED [EC:2.1.1.45]
xref: EC:2.1.1.45
xref: KEGG_REACTION:R02101
xref: MetaCyc:THYMIDYLATESYN-RXN
xref: Reactome:R-HSA-73605 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate"
xref: RHEA:12104
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0004800
name: thyroxine 5'-deiodinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.21.99.4]
synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" RELATED [EC:1.21.99.4]
synonym: "diiodothyronine 5'-deiodinase activity" RELATED [EC:1.21.99.4]
synonym: "iodothyronine 5'-deiodinase activity" RELATED [EC:1.21.99.4]
synonym: "iodothyronine outer ring monodeiodinase activity" RELATED [EC:1.21.99.4]
synonym: "L-thyroxine iodohydrolase (reducing) activity" RELATED [EC:1.21.99.4]
synonym: "outer ring-deiodinating pathway" EXACT [PMID:20403357]
synonym: "thyroxine 5' deiodinase activity" EXACT []
synonym: "thyroxine deiodinase activity" BROAD []
synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.21.99.4]
synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.21.99.4]
xref: EC:1.21.99.4
xref: MetaCyc:THYROXINE-DEIODINASE-RXN
xref: Reactome:R-HSA-209772 "Thyroxine is deiodinated to triiodothyronine"
xref: Reactome:R-HSA-350869 "Thyroxine is deiodinated to reverse triiodothyronine (RT3)"
xref: RHEA:19745
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004801
name: transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [PMID:7592346, RHEA:17053]
synonym: "dihydroxyacetone transferase activity" BROAD [EC:2.2.1.2]
synonym: "dihydroxyacetonetransferase activity" BROAD [EC:2.2.1.2]
synonym: "glycerone transferase activity" BROAD [EC:2.2.1.2]
synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" EXACT [EC:2.2.1.2]
xref: EC:2.2.1.2
xref: MetaCyc:TRANSALDOL-RXN
xref: Reactome:R-HSA-163764 "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate"
xref: Reactome:R-HSA-5659989 "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P"
xref: Reactome:R-HSA-5659998 "Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P"
xref: Reactome:R-HSA-71334 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate"
xref: RHEA:17053
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0004802
name: transketolase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]
synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah]
synonym: "glycoaldehyde transferase activity" RELATED [EC:2.2.1.1]
synonym: "glycolaldehydetransferase activity" RELATED [EC:2.2.1.1]
synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1]
xref: EC:2.2.1.1
xref: Reactome:R-HSA-163741 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate"
xref: Reactome:R-HSA-163751 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate"
xref: Reactome:R-HSA-71324 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate"
xref: Reactome:R-HSA-71335 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate"
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0004803
name: transposase activity
namespace: molecular_function
alt_id: GO:0004804
def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "P-element encoded transposase activity" NARROW []
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0004805
name: trehalose-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate." [EC:3.1.3.12, RHEA:23420]
synonym: "trehalose 6-phosphatase activity" RELATED [EC:3.1.3.12]
synonym: "trehalose 6-phosphate phosphatase activity" RELATED [EC:3.1.3.12]
synonym: "trehalose phosphatase activity" EXACT []
synonym: "trehalose-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.12]
xref: EC:3.1.3.12
xref: MetaCyc:TREHALOSEPHOSPHA-RXN
xref: RHEA:23420
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0004806
name: triacylglycerol lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+." [RHEA:12044]
subset: goslim_chembl
synonym: "amano AP" RELATED [EC:3.1.1.3]
synonym: "amano B" RELATED [EC:3.1.1.3]
synonym: "amano CE" RELATED [EC:3.1.1.3]
synonym: "amano CES" RELATED [EC:3.1.1.3]
synonym: "amano P" RELATED [EC:3.1.1.3]
synonym: "amno N-AP" RELATED [EC:3.1.1.3]
synonym: "butyrinase activity" RELATED [EC:3.1.1.3]
synonym: "cacordase activity" RELATED [EC:3.1.1.3]
synonym: "capalase L" RELATED [EC:3.1.1.3]
synonym: "GA 56" RELATED [EC:3.1.1.3]
synonym: "GEH" RELATED [EC:3.1.1.3]
synonym: "glycerol ester hydrolase activity" RELATED [EC:3.1.1.3]
synonym: "glycerol-ester hydrolase activity" RELATED [EC:3.1.1.3]
synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3]
synonym: "hepatic lipase" NARROW [EC:3.1.1.3]
synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3]
synonym: "lipazin" RELATED [EC:3.1.1.3]
synonym: "liver lipase" NARROW [EC:3.1.1.3]
synonym: "meito MY 30" RELATED [EC:3.1.1.3]
synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3]
synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3]
synonym: "PPL" RELATED [EC:3.1.1.3]
synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3]
synonym: "steapsin" RELATED [EC:3.1.1.3]
synonym: "TAG activity" EXACT [PMID:16054079]
synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3]
synonym: "triacetinase activity" RELATED [EC:3.1.1.3]
synonym: "triacylglycerol acylhydrolase activity" RELATED [EC:3.1.1.3]
synonym: "triacylglycerol ester hydrolase activity" RELATED [EC:3.1.1.3]
synonym: "tributyrase activity" RELATED [EC:3.1.1.3]
synonym: "tributyrin esterase activity" RELATED [EC:3.1.1.3]
synonym: "tributyrinase activity" RELATED [EC:3.1.1.3]
synonym: "triglyceridase activity" RELATED [EC:3.1.1.3]
synonym: "triglyceride hydrolase activity" RELATED [EC:3.1.1.3]
synonym: "triglyceride lipase activity" EXACT []
synonym: "triolein hydrolase activity" RELATED [EC:3.1.1.3]
synonym: "tween hydrolase activity" RELATED [EC:3.1.1.3]
synonym: "tween-hydrolyzing esterase activity" RELATED [EC:3.1.1.3]
synonym: "tweenase activity" RELATED [EC:3.1.1.3]
synonym: "tweenesterase activity" RELATED [EC:3.1.1.3]
xref: EC:3.1.1.3
xref: MetaCyc:RXN-19278
xref: Reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3"
xref: Reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid"
xref: Reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA"
xref: Reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG"
xref: Reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG"
xref: RHEA:12044
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0004807
name: triose-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate." [RHEA:18585]
synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.1]
synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.1]
synonym: "phosphotriose isomerase activity" RELATED [EC:5.3.1.1]
synonym: "triose phosphate mutase activity" RELATED [EC:5.3.1.1]
synonym: "triose phosphoisomerase activity" RELATED [EC:5.3.1.1]
synonym: "triosephosphate isomerase activity" RELATED [EC:5.3.1.1]
synonym: "triosephosphate mutase activity" RELATED [EC:5.3.1.1]
xref: EC:5.3.1.1
xref: KEGG_REACTION:R01015
xref: MetaCyc:TRIOSEPISOMERIZATION-RXN
xref: Reactome:R-HSA-70454 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate"
xref: Reactome:R-HSA-70481 "TPI1 isomerizes GA3P to DHAP"
xref: RHEA:18585
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004808
name: tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
namespace: molecular_function
alt_id: GO:0016425
def: "Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate." [RHEA:19569]
synonym: "tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity" EXACT []
synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" RELATED [EC:2.1.1.61]
xref: EC:2.1.1.61
xref: KEGG_REACTION:R00601
xref: MetaCyc:RXN0-5144
xref: RHEA:19569
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity

[Term]
id: GO:0004809
name: obsolete tRNA (guanine-N2-)-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]
comment: This term was obsoleted because it is an unnecessary grouping term and was obsoleted by EC.
synonym: "guanine-N2-methylase activity" RELATED [EC:2.1.1.32]
synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" RELATED [EC:2.1.1.32]
synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" RELATED [EC:2.1.1.32]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" RELATED [EC:2.1.1.32]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" RELATED [EC:2.1.1.32]
synonym: "transfer ribonucleate guanine 2-methyltransferase activity" RELATED [EC:2.1.1.32]
synonym: "transfer ribonucleate guanine N2-methyltransferase activity" RELATED [EC:2.1.1.32]
is_obsolete: true
consider: GO:0160101
consider: GO:0160102
consider: GO:0160103
consider: GO:0160104

[Term]
id: GO:0004810
name: CCA tRNA nucleotidyltransferase activity
namespace: molecular_function
alt_id: GO:0016437
def: "Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate." [PMID:2247609, RHEA:14433]
synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD []
synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD []
synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.72]
synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD []
synonym: "CTP:tRNA cytidylyltransferase activity" BROAD []
synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.72]
synonym: "ribonucleic cytidylyltransferase" BROAD []
synonym: "transfer ribonucleate adenyltransferase activity" RELATED [EC:2.7.7.72]
synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.72]
synonym: "transfer ribonucleate nucleotidyltransferase" BROAD []
synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD []
synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.72]
synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD []
synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.72]
synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.72]
synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.72]
synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.72]
synonym: "tRNA cytidylyltransferase activity" RELATED []
synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
xref: EC:2.7.7.72
xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN
xref: RHEA:14433
is_a: GO:0070567 ! cytidylyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0004812
name: aminoacyl-tRNA ligase activity
namespace: molecular_function
alt_id: GO:0016876
alt_id: GO:0017100
def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.
synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd]
synonym: "aminoacyl-tRNA synthetase auxiliary protein activity" RELATED []
synonym: "ligase activity, forming aminoacyl-tRNA and related compounds" BROAD []
xref: EC:6.1.1.-
is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0004813
name: alanine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]
synonym: "Ala-tRNA synthetase activity" RELATED [EC:6.1.1.7]
synonym: "alanine transfer RNA synthetase activity" RELATED [EC:6.1.1.7]
synonym: "alanine translase activity" RELATED [EC:6.1.1.7]
synonym: "alanine tRNA synthetase activity" RELATED [EC:6.1.1.7]
synonym: "alanine-transfer RNA ligase activity" RELATED [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleate synthase activity" RELATED [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.7]
synonym: "alanyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.7]
synonym: "alanyl-tRNA synthetase activity" EXACT []
synonym: "AlaRS" RELATED [EC:6.1.1.7]
synonym: "L-alanine:tRNAAla ligase (AMP-forming)" RELATED [EC:6.1.1.7]
xref: EC:6.1.1.7
xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379864 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380177 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate"
xref: RHEA:12540
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004814
name: arginine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]
synonym: "arginine translase activity" RELATED [EC:6.1.1.19]
synonym: "arginine-tRNA synthetase activity" RELATED [EC:6.1.1.19]
synonym: "arginyl transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.19]
synonym: "arginyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.19]
synonym: "arginyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.19]
synonym: "arginyl-tRNA synthetase activity" EXACT []
synonym: "L-arginine:tRNAArg ligase (AMP-forming)" RELATED [EC:6.1.1.19]
xref: EC:6.1.1.19
xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379993 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380224 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate"
xref: RHEA:20301
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004815
name: aspartate-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12]
synonym: "aspartic acid translase activity" RELATED [EC:6.1.1.12]
synonym: "aspartyl ribonucleate synthetase activity" RELATED [EC:6.1.1.12]
synonym: "aspartyl ribonucleic synthetase activity" RELATED [EC:6.1.1.12]
synonym: "aspartyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.12]
synonym: "aspartyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.12]
synonym: "aspartyl-tRNA synthetase activity" EXACT []
synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" RELATED [EC:6.1.1.12]
xref: EC:6.1.1.12
xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379867 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380229 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate"
xref: RHEA:19649
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004816
name: asparagine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+." [EC:6.1.1.22, RHEA:11180]
synonym: "asparagine translase activity" RELATED [EC:6.1.1.22]
synonym: "asparaginyl transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.22]
synonym: "asparaginyl transfer RNA synthetase activity" RELATED [EC:6.1.1.22]
synonym: "asparaginyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.22]
synonym: "asparaginyl-tRNA synthetase activity" EXACT []
synonym: "asparagyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.22]
synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" RELATED [EC:6.1.1.22]
xref: EC:6.1.1.22
xref: KEGG_REACTION:R03648
xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379996 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380227 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate"
xref: RHEA:11180
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004817
name: cysteine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16]
synonym: "cysteine translase activity" RELATED [EC:6.1.1.16]
synonym: "cysteinyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.16]
synonym: "cysteinyl-transferRNA synthetase activity" RELATED [EC:6.1.1.16]
synonym: "cysteinyl-tRNA synthetase activity" EXACT []
synonym: "L-cysteine:tRNACys ligase (AMP-forming)" RELATED [EC:6.1.1.16]
xref: EC:6.1.1.16
xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379887 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380158 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate"
xref: RHEA:17773
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004818
name: glutamate-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]
synonym: "glutamate-tRNA synthetase activity" RELATED [EC:6.1.1.17]
synonym: "glutamic acid translase activity" RELATED [EC:6.1.1.17]
synonym: "glutamyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.17]
synonym: "glutamyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.17]
synonym: "glutamyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.17]
synonym: "glutamyl-tRNA synthetase activity" EXACT []
synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" RELATED [EC:6.1.1.17]
xref: EC:6.1.1.17
xref: MetaCyc:GLURS-RXN
xref: Reactome:R-HSA-379861 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380216 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate"
xref: RHEA:23540
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004819
name: glutamine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
synonym: "GlnRS" RELATED [EC:6.1.1.18]
synonym: "glutamine translase activity" RELATED [EC:6.1.1.18]
synonym: "glutamine-tRNA synthetase activity" RELATED [EC:6.1.1.18]
synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18]
synonym: "glutaminyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.18]
synonym: "glutaminyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.18]
synonym: "glutaminyl-tRNA synthetase activity" EXACT []
synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" RELATED [EC:6.1.1.18]
xref: EC:6.1.1.18
xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379982 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380241 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate"
xref: RHEA:20121
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004820
name: glycine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14]
synonym: "glycine:tRNAGly ligase (AMP-forming) activity" RELATED [EC:6.1.1.14]
synonym: "glycyl translase activity" RELATED [EC:6.1.1.14]
synonym: "glycyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.14]
synonym: "glycyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.14]
synonym: "glycyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.14]
synonym: "glycyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.14
xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-380048 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380240 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate"
xref: RHEA:16013
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004821
name: histidine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21]
synonym: "histidine translase activity" RELATED [EC:6.1.1.21]
synonym: "histidyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.21]
synonym: "histidyl-tRNA synthetase activity" EXACT []
synonym: "L-histidine:tRNAHis ligase (AMP-forming)" RELATED [EC:6.1.1.21]
xref: EC:6.1.1.21
xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379844 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380234 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate"
xref: RHEA:17313
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004822
name: isoleucine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+." [EC:6.1.1.5, RHEA:11060]
synonym: "isoleucine translase activity" RELATED [EC:6.1.1.5]
synonym: "isoleucine-transfer RNA ligase activity" RELATED [EC:6.1.1.5]
synonym: "isoleucine-tRNA synthetase activity" RELATED [EC:6.1.1.5]
synonym: "isoleucyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.5]
synonym: "isoleucyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.5]
synonym: "isoleucyl-tRNA synthetase activity" EXACT []
synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" RELATED [EC:6.1.1.5]
xref: EC:6.1.1.5
xref: KEGG_REACTION:R03656
xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379893 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380176 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate"
xref: RHEA:11060
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004823
name: leucine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu)." [RHEA:11688]
synonym: "leucine translase activity" RELATED [EC:6.1.1.4]
synonym: "leucine-tRNA synthetase activity" RELATED [EC:6.1.1.4]
synonym: "leucine:tRNALeu ligase (AMP-forming)" RELATED [EC:6.1.1.4]
synonym: "leucyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.4]
synonym: "leucyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.4]
synonym: "leucyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.4]
synonym: "leucyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.4
xref: KEGG_REACTION:R03657
xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379974 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380200 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate"
xref: RHEA:11688
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004824
name: lysine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6]
synonym: "L-lysine-transfer RNA ligase activity" RELATED [EC:6.1.1.6]
synonym: "L-lysine:tRNALys ligase (AMP-forming)" RELATED [EC:6.1.1.6]
synonym: "lysine translase activity" RELATED [EC:6.1.1.6]
synonym: "lysine-tRNA synthetase activity" RELATED [EC:6.1.1.6]
synonym: "lysyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.6]
synonym: "lysyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.6]
synonym: "lysyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.6
xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-380008 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380233 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate"
xref: RHEA:20792
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004825
name: methionine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10]
synonym: "L-methionine:tRNAMet ligase (AMP-forming)" RELATED [EC:6.1.1.10]
synonym: "methionine translase activity" RELATED [EC:6.1.1.10]
synonym: "methionyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.10]
synonym: "methionyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.10]
synonym: "methionyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.10]
synonym: "methionyl-tRNA synthetase activity" EXACT []
synonym: "MetRS activity" RELATED [EC:6.1.1.10]
xref: EC:6.1.1.10
xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379994 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380157 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate"
xref: RHEA:13481
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004826
name: phenylalanine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" RELATED [EC:6.1.1.20]
synonym: "L-phenylalanyl-tRNA synthetase activity" RELATED [EC:6.1.1.20]
synonym: "phenylalanine translase activity" RELATED [EC:6.1.1.20]
synonym: "phenylalanine-tRNA synthetase activity" RELATED [EC:6.1.1.20]
synonym: "phenylalanyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.20]
synonym: "phenylalanyl-transfer RNA ligase activity" RELATED [EC:6.1.1.20]
synonym: "phenylalanyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.20]
synonym: "phenylalanyl-tRNA ligase activity" RELATED [EC:6.1.1.20]
synonym: "phenylalanyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.20
xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379848 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380203 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate"
xref: RHEA:19413
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004827
name: proline-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15]
synonym: "L-proline:tRNAPro ligase (AMP-forming)" RELATED [EC:6.1.1.15]
synonym: "proline translase activity" RELATED [EC:6.1.1.15]
synonym: "prolinyl-tRNA ligase activity" RELATED [EC:6.1.1.15]
synonym: "prolyl-s-RNA synthetase activity" RELATED [EC:6.1.1.15]
synonym: "prolyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.15]
synonym: "prolyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.15]
synonym: "prolyl-transferRNA synthetase activity" RELATED [EC:6.1.1.15]
synonym: "prolyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.15
xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379865 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380198 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate"
xref: RHEA:14305
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004828
name: serine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). Also catalyzes the formation of L-seryl-tRNA(Sec) from tRNA(Sec), the special tRNA for selenocysteine." [EC:6.1.1.11]
synonym: "L-serine:tRNASer ligase (AMP-forming)" RELATED [EC:6.1.1.11]
synonym: "serine translase activity" RELATED [EC:6.1.1.11]
synonym: "SerRS activity" RELATED [EC:6.1.1.11]
synonym: "seryl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.11]
synonym: "seryl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.11]
synonym: "seryl-transfer RNA synthetase activity" RELATED [EC:6.1.1.11]
synonym: "seryl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.11
xref: MetaCyc:SERINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379992 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380239 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004829
name: threonine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3]
synonym: "L-threonine:tRNAThr ligase (AMP-forming)" RELATED [EC:6.1.1.3]
synonym: "threonine translase activity" RELATED [EC:6.1.1.3]
synonym: "threonine-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.3]
synonym: "threonyl ribonucleic synthetase activity" RELATED [EC:6.1.1.3]
synonym: "threonyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.3]
synonym: "threonyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.3]
synonym: "threonyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.3]
synonym: "threonyl-tRNA synthetase activity" EXACT []
synonym: "TRS" RELATED [EC:6.1.1.3]
xref: EC:6.1.1.3
xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-380002 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380201 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate"
xref: RHEA:24624
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004830
name: tryptophan-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]
synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" RELATED [EC:6.1.1.2]
synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" RELATED [EC:6.1.1.2]
synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" RELATED [EC:6.1.1.2]
synonym: "TrpRS activity" RELATED [EC:6.1.1.2]
synonym: "tryptophan translase activity" RELATED [EC:6.1.1.2]
synonym: "tryptophanyl ribonucleic synthetase activity" RELATED [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleic synthetase activity" RELATED [EC:6.1.1.2]
synonym: "tryptophanyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.2]
synonym: "tryptophanyl-tRNA synthase activity" RELATED [EC:6.1.1.2]
synonym: "tryptophanyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.2
xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379977 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380222 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate"
xref: RHEA:24080
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004831
name: tyrosine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+." [EC:6.1.1.1, RHEA:10220]
synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" RELATED [EC:6.1.1.1]
synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" RELATED [EC:6.1.1.1]
synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" RELATED [EC:6.1.1.1]
synonym: "tyrosine translase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosine tRNA synthetase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosine-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosine-transfer RNA ligase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosyl-tRNA ligase activity" RELATED [EC:6.1.1.1]
synonym: "tyrosyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.1
xref: KEGG_REACTION:R02918
xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379980 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380170 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate"
xref: RHEA:10220
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004832
name: valine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+." [EC:6.1.1.9, RHEA:10704]
synonym: "L-valine:tRNAVal ligase (AMP-forming)" RELATED [EC:6.1.1.9]
synonym: "valine transfer ribonucleate ligase activity" RELATED [EC:6.1.1.9]
synonym: "valine translase activity" RELATED [EC:6.1.1.9]
synonym: "valyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.9]
synonym: "valyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.9]
synonym: "valyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.9]
synonym: "valyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.9
xref: KEGG_REACTION:R03665
xref: MetaCyc:VALINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-380042 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380199 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate"
xref: RHEA:10704
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004833
name: tryptophan 2,3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0004426
def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]
synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11]
synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT []
synonym: "L-tryptophan 2,3-dioxygenase activity" RELATED [EC:1.13.11.11]
synonym: "L-tryptophan pyrrolase activity" RELATED [EC:1.13.11.11]
synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.11]
synonym: "TDO" RELATED [EC:1.13.11.11]
synonym: "tryptamin 2,3-dioxygenase activity" RELATED [EC:1.13.11.11]
synonym: "tryptamine 2,3-dioxygenase activity" RELATED [EC:1.13.11.11]
synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11]
synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11]
synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11]
xref: EC:1.13.11.11
xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN
xref: Reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK"
xref: Reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK"
xref: Reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK"
xref: RHEA:24536
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004834
name: tryptophan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [RHEA:10532]
synonym: "indoleglycerol phosphate aldolase activity" RELATED [EC:4.2.1.20]
synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" RELATED [EC:4.2.1.20]
synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20]
synonym: "L-tryptophan synthetase activity" RELATED [EC:4.2.1.20]
synonym: "tryptophan desmolase activity" RELATED [EC:4.2.1.20]
synonym: "tryptophan synthetase activity" RELATED [EC:4.2.1.20]
xref: EC:4.2.1.20
xref: KEGG_REACTION:R02722
xref: MetaCyc:TRYPSYN-RXN
xref: RHEA:10532
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004835
name: tubulin-tyrosine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" RELATED [EC:6.3.2.25]
synonym: "TTL activity" RELATED [EC:6.3.2.25]
synonym: "tubulinyl-tyrosine ligase activity" EXACT []
xref: EC:6.3.2.25
xref: MetaCyc:6.3.2.25-RXN
xref: Reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin"
xref: RHEA:17605
is_a: GO:0016881 ! acid-amino acid ligase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0004836
name: tyramine-beta hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004837
name: tyrosine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
synonym: "L-(-)-tyrosine apodecarboxylase activity" RELATED [EC:4.1.1.25]
synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" RELATED [EC:4.1.1.25]
synonym: "L-tyrosine carboxy-lyase activity" RELATED [EC:4.1.1.25]
synonym: "L-tyrosine decarboxylase activity" RELATED [EC:4.1.1.25]
xref: EC:4.1.1.25
xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN
xref: RHEA:14345
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004838
name: L-tyrosine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [RHEA:15093]
synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5]
synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "L-tyrosine transaminase activity" BROAD []
synonym: "L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT []
synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5]
synonym: "TyrAT activity" RELATED [EC:2.6.1.5]
synonym: "tyrosine aminotransferase activity" BROAD []
synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5]
xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-517444 "TAT aminates HPP"
xref: Reactome:R-HSA-71155 "TAT deaminates tyrosine"
xref: RHEA:15093
xref: UM-BBD_reactionID:r0297
is_a: GO:0008793 ! aromatic-amino-acid transaminase activity

[Term]
id: GO:0004839
name: ubiquitin activating enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme]
comment: The ubiquitin activating enzyme catalyzes a ligation reaction.
synonym: "E1 ubiquitin-activating enzyme" RELATED [EC:6.2.1.45]
xref: EC:6.2.1.45
xref: Reactome:R-HSA-8852132 "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol"
xref: Reactome:R-HSA-8852133 "UBA1 conjugates ubiquitin to UBA1 in the cytosol"
xref: Reactome:R-HSA-8852134 "UBA1 adenylates ubiquitin in the cytosol"
xref: Reactome:R-HSA-8865050 "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol"
xref: Reactome:R-HSA-8865090 "UBA6 adenylates ubiquitin in the cytosol"
xref: Reactome:R-HSA-8865098 "UBA6 conjugates ubiquitin to UBA6 in the cytosol"
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0004842
name: ubiquitin-protein transferase activity
namespace: molecular_function
alt_id: GO:0004840
alt_id: GO:0004841
def: "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
synonym: "E2" BROAD []
synonym: "E3" BROAD []
synonym: "ubiquitin conjugating enzyme activity" NARROW []
synonym: "ubiquitin ligase activity" NARROW []
synonym: "ubiquitin protein ligase activity" NARROW []
synonym: "ubiquitin protein-ligase activity" NARROW []
synonym: "ubiquitin-conjugating enzyme activity" NARROW []
xref: KEGG_REACTION:R03876
xref: Reactome:R-HSA-1169394 "ISGylation of IRF3"
xref: Reactome:R-HSA-1169395 "ISGylation of viral protein NS1"
xref: Reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase"
xref: Reactome:R-HSA-1169398 "ISGylation of host protein filamin B"
xref: Reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes"
xref: Reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)"
xref: Reactome:R-HSA-1169406 "ISGylation of host proteins"
xref: Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha"
xref: Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha"
xref: Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH"
xref: Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41"
xref: Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3"
xref: Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3"
xref: Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)"
xref: Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex"
xref: Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2"
xref: Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling"
xref: Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP"
xref: Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:R-HSA-179417 "Multiubiquitination of Nek2A"
xref: Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G"
xref: Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex"
xref: Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85"
xref: Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)"
xref: Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty"
xref: Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix"
xref: Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty"
xref: Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7"
xref: Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21"
xref: Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX"
xref: Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand"
xref: Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2"
xref: Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2"
xref: Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer"
xref: Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1"
xref: Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination"
xref: Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling"
xref: Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6"
xref: Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6"
xref: Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF"
xref: Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex"
xref: Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34"
xref: Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7"
xref: Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2"
xref: Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3"
xref: Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2"
xref: Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7"
xref: Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3"
xref: Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3"
xref: Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )"
xref: Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels"
xref: Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6"
xref: Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants"
xref: Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants"
xref: Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants"
xref: Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA"
xref: Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56"
xref: Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21"
xref: Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1"
xref: Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2"
xref: Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1"
xref: Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2"
xref: Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)"
xref: Reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins"
xref: Reactome:R-HSA-4332236 "CBL neddylates TGFBR2"
xref: Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated"
xref: Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation"
xref: Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1"
xref: Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1"
xref: Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments"
xref: Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated"
xref: Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP"
xref: Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex"
xref: Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates"
xref: Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1"
xref: Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1"
xref: Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2"
xref: Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3"
xref: Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA"
xref: Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH"
xref: Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA"
xref: Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP"
xref: Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP"
xref: Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3"
xref: Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK"
xref: Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated"
xref: Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2"
xref: Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2"
xref: Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains"
xref: Reactome:R-HSA-68712 "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1"
xref: Reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A"
xref: Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO"
xref: Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1"
xref: Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4"
xref: Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3"
xref: Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha"
xref: Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3"
xref: Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex"
xref: Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex"
xref: Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated"
xref: Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS"
xref: Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2"
xref: Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains"
xref: Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation"
xref: Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation"
xref: Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer"
xref: Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363"
xref: Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates"
xref: Reactome:R-HSA-9750946 "TRAF2,6 ubiquitinates NLRC5"
xref: Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex"
xref: Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane"
xref: Reactome:R-HSA-9758604 "Ubiquitination of IKBKG by TRAF6"
xref: Reactome:R-HSA-9793444 "ITCH polyubiquitinates MLKL at K50"
xref: Reactome:R-HSA-9793485 "PRKN polyubiquitinates RIPK3"
xref: Reactome:R-HSA-9793679 "LUBAC ubiquitinates RIPK1 at K627"
xref: Reactome:R-HSA-9796346 "MIB2 ubiquitinates RIPK1 at K377, K604, K634"
xref: Reactome:R-HSA-9796387 "STUB1 ubiquitinates RIPK1 at K571, K604, K627"
xref: Reactome:R-HSA-9796626 "MIB2 ubiquitinates CFLAR"
xref: Reactome:R-HSA-9815507 "MIB2 ubiquitinates CYLD at K338, K530"
xref: Reactome:R-HSA-9817362 "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex"
xref: Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2"
xref: Reactome:R-HSA-983153 "E1 mediated ubiquitin activation"
xref: Reactome:R-HSA-983156 "Polyubiquitination of substrate"
xref: Reactome:R-HSA-9833155 "Ubiquitination of STAT2"
xref: Reactome:R-HSA-9833973 "ISGylation of PKR"
xref: Reactome:R-HSA-9834070 "PRKN ubiquitinates MOM substrates"
xref: Reactome:R-HSA-9861563 "CTLH E3 ligase ubiquitinates LDHA"
xref: Reactome:R-HSA-9861640 "CTLH E3 ligase ubiquitinates PKM-1"
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0004843
name: cysteine-type deubiquitinase activity
namespace: molecular_function
alt_id: GO:0036459
def: "An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]
synonym: "deubiquitinase" BROAD [GOC:vw, PMID:19261746]
synonym: "deubiquitinase activity" BROAD [GOC:bf]
synonym: "deubiquitinating enzyme" BROAD [PMID:19188440]
synonym: "deubiquitylase" BROAD [GOC:vw, PMID:15657442]
synonym: "thiol-dependent deubiquitinase" EXACT []
synonym: "thiol-dependent ubiquitin-specific protease activity" EXACT []
synonym: "thiol-dependent ubiquitinyl hydrolase activity" EXACT []
synonym: "ubiquitin C-terminal hydrolase" RELATED [EC:3.4.19.12]
synonym: "ubiquitin hydrolase activity" BROAD [GOC:rl]
synonym: "ubiquitin-specific protease activity" BROAD []
synonym: "ubiquitinyl hydrolase 1 activity" NARROW []
synonym: "ubiquitinyl hydrolase activity" BROAD []
synonym: "UBP" NARROW []
synonym: "UCH2" NARROW []
xref: EC:3.4.19.12
xref: Reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8"
xref: Reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1"
xref: Reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2"
xref: Reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2"
xref: Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2"
xref: Reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling"
xref: Reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA"
xref: Reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA"
xref: Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains"
xref: Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2"
xref: Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN"
xref: Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4"
xref: Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53"
xref: Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B"
xref: Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin"
xref: Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A"
xref: Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58"
xref: Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128"
xref: Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts"
xref: Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1"
xref: Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex"
xref: Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A"
xref: Reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1"
xref: Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1"
xref: Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58"
xref: Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1"
xref: Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR"
xref: Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG"
xref: Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins"
xref: Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC"
xref: Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB"
xref: Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB"
xref: Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20"
xref: Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B"
xref: Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2"
xref: Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2"
xref: Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2"
xref: Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1"
xref: Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10"
xref: Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123"
xref: Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA"
xref: Reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6"
xref: Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR"
xref: Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS"
xref: Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3"
xref: Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33"
xref: Reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48"
xref: Reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN"
xref: Reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN"
xref: Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4"
xref: Reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin"
xref: Reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin"
xref: Reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin"
xref: Reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin"
xref: Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin"
xref: Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb"
xref: Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6"
xref: Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN"
xref: Reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1"
xref: Reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1"
xref: Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin"
xref: Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin"
xref: Reactome:R-HSA-9653514 "USP17L2 deubiquitinates RCE1"
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0101005 ! deubiquitinase activity

[Term]
id: GO:0004844
name: uracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623]
synonym: "uracil-DNA glycosylase activity" EXACT []
xref: EC:3.2.2.27
xref: Reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase"
xref: Reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase"
xref: Reactome:R-HSA-9817512 "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3"
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity

[Term]
id: GO:0004845
name: uracil phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13017]
synonym: "UMP diphosphorylase activity" RELATED [EC:2.4.2.9]
synonym: "UMP pyrophosphorylase activity" RELATED [EC:2.4.2.9]
synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.9]
synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.9]
synonym: "UPRTase activity" RELATED [EC:2.4.2.9]
synonym: "uridine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.9]
synonym: "uridine monophosphate pyrophosphorylase activity" RELATED [EC:2.4.2.9]
synonym: "uridylate pyrophosphorylase activity" RELATED [EC:2.4.2.9]
synonym: "uridylic pyrophosphorylase activity" RELATED [EC:2.4.2.9]
xref: EC:2.4.2.9
xref: KEGG_REACTION:R00966
xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN
xref: RHEA:13017
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0004846
name: urate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide." [EC:1.7.3.3]
synonym: "urate:oxygen oxidoreductase activity" RELATED [EC:1.7.3.3]
synonym: "uric acid oxidase activity" RELATED [EC:1.7.3.3]
synonym: "uricase activity" RELATED [EC:1.7.3.3]
synonym: "uricase II activity" NARROW [EC:1.7.3.3]
xref: EC:1.7.3.3
xref: MetaCyc:URATE-OXIDASE-RXN
xref: RHEA:21368
xref: UM-BBD_reactionID:r1322
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0004847
name: urea carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate." [EC:6.3.4.6, RHEA:20896]
synonym: "ATP--urea amidolyase activity" RELATED [EC:6.3.4.6]
synonym: "UALase activity" RELATED [EC:6.3.4.6]
synonym: "UCA activity" RELATED [EC:6.3.4.6]
synonym: "urea amidolyase activity" RELATED [EC:6.3.4.6]
synonym: "urea carboxylase (hydrolysing)" RELATED [EC:6.3.4.6]
synonym: "urea carboxylase (hydrolyzing) activity" RELATED [EC:6.3.4.6]
synonym: "urea:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.3.4.6]
synonym: "urease (ATP-hydrolysing)" RELATED [EC:6.3.4.6]
synonym: "urease (ATP-hydrolyzing) activity" RELATED [EC:6.3.4.6]
xref: EC:6.3.4.6
xref: KEGG_REACTION:R00774
xref: MetaCyc:UREA-CARBOXYLASE-RXN
xref: RHEA:20896
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004848
name: ureidoglycolate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4." [RHEA:19809]
comment: Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.1.116, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.1.116) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.1.116 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
synonym: "ureidoglycolate amidohydrolase activity" EXACT []
xref: EC:3.5.1.116
xref: KEGG_REACTION:R00469
xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN
xref: RHEA:19809
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004849
name: uridine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [RHEA:16825]
synonym: "uridine phosphokinase activity" EXACT []
synonym: "uridine-cytidine kinase activity" NARROW [EC:2.7.1.48]
xref: MetaCyc:URIDINEKIN-RXN
xref: Reactome:R-HSA-8954327 "UCKL1 phosphorylates urindine, cytidine"
xref: RHEA:16825
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0004850
name: uridine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3]
synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3]
synonym: "UPase activity" RELATED [EC:2.4.2.3]
synonym: "UPH" RELATED [EC:2.4.2.3]
synonym: "UrdPase activity" RELATED [EC:2.4.2.3]
synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.3]
xref: EC:2.4.2.3
xref: MetaCyc:URPHOS-RXN
xref: Reactome:R-HSA-74372 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]"
xref: Reactome:R-HSA-74376 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)"
xref: RHEA:24388
is_a: GO:0016154 ! pyrimidine-nucleoside phosphorylase activity

[Term]
id: GO:0004851
name: uroporphyrin-III C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107]
synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" RELATED [EC:2.1.1.107]
synonym: "CobA" RELATED [EC:2.1.1.107]
synonym: "CysG" RELATED [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" RELATED [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" RELATED [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" RELATED [EC:2.1.1.107]
synonym: "SirA" RELATED [EC:2.1.1.107]
synonym: "SUMT activity" RELATED [EC:2.1.1.107]
synonym: "urogen III methylase activity" RELATED [EC:2.1.1.107]
synonym: "uroporphyrinogen III methylase activity" RELATED [EC:2.1.1.107]
synonym: "uroporphyrinogen methyltransferase activity" RELATED [EC:2.1.1.107]
synonym: "uroporphyrinogen-III C-methyltransferase activity" RELATED [EC:2.1.1.107]
synonym: "uroporphyrinogen-III methylase activity" RELATED [EC:2.1.1.107]
synonym: "uroporphyrinogen-III methyltransferase activity" RELATED [EC:2.1.1.107]
xref: EC:2.1.1.107
xref: MetaCyc:RXN-13403
xref: RHEA:32459
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004852
name: uroporphyrinogen-III synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18965]
synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" RELATED [EC:4.2.1.75]
synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" RELATED [EC:4.2.1.75]
synonym: "porphobilinogenase activity" RELATED [EC:4.2.1.75]
synonym: "URO-synthase activity" RELATED [EC:4.2.1.75]
synonym: "uroporphyrinogen III cosynthase activity" RELATED [EC:4.2.1.75]
synonym: "uroporphyrinogen isomerase activity" RELATED [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthase activity" RELATED [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthetase activity" RELATED [EC:4.2.1.75]
xref: EC:4.2.1.75
xref: KEGG_REACTION:R03165
xref: MetaCyc:UROGENIIISYN-RXN
xref: Reactome:R-HSA-189488 "UROS transforms HMB to URO3"
xref: RHEA:18965
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004853
name: uroporphyrinogen decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37]
synonym: "porphyrinogen carboxy-lyase activity" RELATED [EC:4.1.1.37]
synonym: "porphyrinogen decarboxylase activity" RELATED [EC:4.1.1.37]
synonym: "uroporphyrinogen III decarboxylase activity" RELATED [EC:4.1.1.37]
synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" RELATED [EC:4.1.1.37]
synonym: "uroporphyrinogen-III carboxy-lyase activity" RELATED [EC:4.1.1.37]
xref: EC:4.1.1.37
xref: MetaCyc:UROGENDECARBOX-RXN
xref: RHEA:19865
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004854
name: xanthine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4]
synonym: "NAD-xanthine dehydrogenase activity" RELATED [EC:1.17.1.4]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4]
synonym: "xanthine-NAD oxidoreductase activity" RELATED [EC:1.17.1.4]
synonym: "xanthine/NAD(+) oxidoreductase activity" RELATED [EC:1.17.1.4]
synonym: "xanthine/NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4]
synonym: "xanthine:NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4]
xref: EC:1.17.1.4
xref: MetaCyc:RXN0-901
xref: Reactome:R-HSA-9727349 "XDH dehydrogenates xanthine to form urate"
xref: RHEA:16669
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0004855
name: xanthine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2]
synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2]
synonym: "schardinger enzyme" RELATED [EC:1.17.3.2]
synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2]
synonym: "xanthine:O2 oxidoreductase activity" RELATED [EC:1.17.3.2]
synonym: "xanthine:oxygen oxidoreductase activity" RELATED [EC:1.17.3.2]
synonym: "xanthine:xanthine oxidase activity" RELATED [EC:1.17.3.2]
xref: EC:1.17.3.2
xref: MetaCyc:XANTHINE-OXIDASE-RXN
xref: Reactome:R-HSA-74258 "XDH oxidizes xanthine to form urate"
xref: Reactome:R-HSA-9748991 "XDH oxidises 6MP to 6TU"
xref: RHEA:21132
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0004856
name: D-xylulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H+." [EC:2.7.1.17, RHEA:10964]
synonym: "ATP:D-xylulose 5-phosphotransferase activity" RELATED [EC:2.7.1.17]
synonym: "xylulokinase (phosphorylating)" RELATED [EC:2.7.1.17]
synonym: "xylulokinase activity" BROAD []
synonym: "xylulose kinase activity" RELATED [EC:2.7.1.17]
xref: EC:2.7.1.17
xref: KEGG_REACTION:R01639
xref: MetaCyc:XYLULOKIN-RXN
xref: Reactome:R-HSA-5662466 "XYLB phosphorylates D-xylulose"
xref: RHEA:10964
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004857
name: enzyme inhibitor activity
namespace: molecular_function
alt_id: GO:0048551
def: "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]
comment: This term should only be used in cases when the regulator directly interacts with the enzyme.
synonym: "metalloenzyme inhibitor activity" NARROW []
is_a: GO:0030234 ! enzyme regulator activity
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0004858
name: dUTP pyrophosphatase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0004859
name: phospholipase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl]
is_a: GO:0055102 ! lipase inhibitor activity

[Term]
id: GO:0004860
name: protein kinase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a protein kinase." [GOC:ai]
is_a: GO:0019210 ! kinase inhibitor activity
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0004861
name: cyclin-dependent protein serine/threonine kinase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr]
synonym: "CDK inhibitor" RELATED []
synonym: "cyclin dependent kinase inhibitor" RELATED []
synonym: "cyclin dependent protein kinase inhibitor activity" EXACT []
synonym: "cyclin-dependent kinase inhibitor" RELATED []
synonym: "cyclin-dependent protein kinase inhibitor activity" BROAD []
xref: Reactome:R-HSA-187934 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21"
xref: Reactome:R-HSA-69562 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21"
is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity

[Term]
id: GO:0004862
name: cAMP-dependent protein kinase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah]
xref: Reactome:R-HSA-180073 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function"
is_a: GO:0008603 ! cAMP-dependent protein kinase regulator activity
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity

[Term]
id: GO:0004864
name: protein phosphatase inhibitor activity
namespace: molecular_function
alt_id: GO:1990681
def: "Binds to and stops, prevents or reduces the activity of a protein phosphatase." [GOC:ai]
synonym: "phosphoprotein phosphatase inhibitor activity" EXACT []
synonym: "protein phosphatase 2 inhibitor activity" NARROW [GOC:dph]
synonym: "protein phosphatase type 2A inhibitor activity" NARROW []
is_a: GO:0019212 ! phosphatase inhibitor activity
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0004865
name: protein serine/threonine phosphatase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb]
is_a: GO:0004864 ! protein phosphatase inhibitor activity

[Term]
id: GO:0004866
name: endopeptidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]
synonym: "alpha-2 macroglobulin" RELATED []
synonym: "endoproteinase inhibitor" NARROW []
synonym: "proteinase inhibitor" NARROW []
is_a: GO:0030414 ! peptidase inhibitor activity
is_a: GO:0061135 ! endopeptidase regulator activity

[Term]
id: GO:0004867
name: serine-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]
synonym: "serine protease inhibitor activity" NARROW []
synonym: "serine proteinase inhibitor activity" NARROW []
synonym: "serpin activity" NARROW []
xref: Reactome:R-HSA-158795 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1"
xref: Reactome:R-HSA-158800 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1"
xref: Reactome:R-HSA-158893 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin"
xref: Reactome:R-HSA-159001 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR"
xref: Reactome:R-HSA-159005 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR"
is_a: GO:0004866 ! endopeptidase inhibitor activity

[Term]
id: GO:0004868
name: obsolete serpin
namespace: molecular_function
def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "serpin" EXACT []
is_obsolete: true
consider: GO:0004867

[Term]
id: GO:0004869
name: cysteine-type endopeptidase inhibitor activity
namespace: molecular_function
alt_id: GO:0004870
def: "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]
synonym: "cystatin" NARROW [GOC:jl]
synonym: "cysteine protease inhibitor activity" NARROW [GOC:dph, GOC:tb]
synonym: "thiol protease inhibitor" NARROW []
is_a: GO:0004866 ! endopeptidase inhibitor activity

[Term]
id: GO:0004871
name: obsolete signal transducer activity
namespace: molecular_function
alt_id: GO:0005062
alt_id: GO:0009369
alt_id: GO:0009370
def: "OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
comment: This term was obsoleted because it was not clearly defined and is not a useful grouping term.
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW []
synonym: "quorum sensing response regulator activity" NARROW []
synonym: "quorum sensing signal generator activity" NARROW []
is_obsolete: true

[Term]
id: GO:0004873
name: asialoglycoprotein receptor activity
namespace: molecular_function
def: "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein]
subset: goslim_chembl
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0004874
name: obsolete aryl hydrocarbon receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding." [GOC:ai, PMID:1325649, PMID:7493958, Wikipedia:Aryl_hydrocarbon_receptor]
comment: This term was obsoleted because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0004875
name: complement receptor activity
namespace: molecular_function
alt_id: GO:0004942
def: "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446]
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
synonym: "anaphylatoxin receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140375 ! immune receptor activity

[Term]
id: GO:0004876
name: complement component C3a receptor activity
namespace: molecular_function
alt_id: GO:0004943
def: "Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149]
synonym: "C3a anaphylatoxin receptor activity" RELATED []
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0004877
name: complement component C3b receptor activity
namespace: molecular_function
def: "Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0004878
name: complement component C5a receptor activity
namespace: molecular_function
alt_id: GO:0004944
def: "Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149]
synonym: "C5a anaphylatoxin receptor activity" RELATED []
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0004879
name: nuclear receptor activity
namespace: molecular_function
alt_id: GO:0003708
alt_id: GO:0004880
alt_id: GO:0004882
alt_id: GO:0004884
alt_id: GO:0004886
alt_id: GO:0004887
alt_id: GO:0008434
alt_id: GO:0038050
alt_id: GO:0038051
alt_id: GO:0038052
def: "A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]
comment: Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol]
synonym: "9-cis retinoic acid receptor activity" NARROW []
synonym: "androgen receptor activity" NARROW []
synonym: "calcitriol receptor activity" NARROW []
synonym: "ecdysteroid hormone receptor activity" NARROW []
synonym: "estrogen nuclear receptor activity" NARROW [GOC:bf]
synonym: "glucocorticoid receptor activity" NARROW [GOC:bf]
synonym: "juvenile hormone receptor activity" NARROW []
synonym: "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf]
synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf]
synonym: "nuclear hormone receptor" NARROW []
synonym: "retinoic acid receptor activity" NARROW []
synonym: "retinoid-X receptor activity" NARROW [GOC:bf]
synonym: "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT []
synonym: "RXR" NARROW []
synonym: "thyroid hormone receptor activity" NARROW []
synonym: "vitamin A receptor activity" NARROW []
synonym: "vitamin D receptor activity" NARROW []
synonym: "vitamin D3 receptor activity" NARROW [GOC:bf, Wikipedia:Calcitriol_receptor]
is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
is_a: GO:0038023 ! signaling receptor activity
is_a: GO:0098531 ! ligand-modulated transcription factor activity

[Term]
id: GO:0004883
name: nuclear glucocorticoid receptor activity
namespace: molecular_function
def: "A nuclear receptor activity regulated by glucocorticoid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:signaling, PMID:17689856, PMID:20920967]
synonym: "glucocorticoid receptor activity" BROAD []
is_a: GO:0003707 ! nuclear steroid receptor activity

[Term]
id: GO:0004888
name: transmembrane signaling receptor activity
namespace: molecular_function
alt_id: GO:0004926
alt_id: GO:0099600
def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling]
synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex"
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0004890
name: GABA-A receptor activity
namespace: molecular_function
def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
synonym: "ionotropic GABA receptor activity" EXACT [GOC:bf]
is_a: GO:0016917 ! GABA receptor activity

[Term]
id: GO:0004892
name: obsolete B cell receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
synonym: "B cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0003823

[Term]
id: GO:0004894
name: obsolete T cell receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
synonym: "T cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0004895
name: cell adhesion receptor activity
namespace: molecular_function
def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins." [GOC:BHF-UCL, Wikipedia:Cell_adhesion]
comment: Reinstated term from obsolete.
is_a: GO:0038023 ! signaling receptor activity
is_a: GO:0098631 ! cell adhesion mediator activity

[Term]
id: GO:0004896
name: cytokine receptor activity
namespace: molecular_function
alt_id: GO:0004907
def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED []
synonym: "IL receptor" NARROW []
synonym: "interleukin receptor activity" NARROW [http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140375 ! immune receptor activity

[Term]
id: GO:0004897
name: ciliary neurotrophic factor receptor activity
namespace: molecular_function
def: "Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "CNTF receptor activity" EXACT [GOC:mah]
synonym: "gp130" RELATED []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004898
name: obsolete gp130
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a gene product.
synonym: "gp130" EXACT []
is_obsolete: true
consider: GO:0004897
consider: GO:0004915
consider: GO:0004921

[Term]
id: GO:0004900
name: erythropoietin receptor activity
namespace: molecular_function
def: "Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004901
name: granulocyte macrophage colony-stimulating factor receptor activity
namespace: molecular_function
alt_id: GO:0030525
def: "Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "CSF-2 receptor activity" EXACT [GOC:bf]
synonym: "CSF2R" RELATED [GOC:bf]
synonym: "GM-CSF receptor activity" EXACT []
synonym: "GMC-SF receptor activity" EXACT []
synonym: "granulocyte macrophage colony stimulating factor receptor activity" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004902
name: granulocyte colony-stimulating factor receptor activity
namespace: molecular_function
alt_id: GO:0030524
def: "Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "CSF3R" RELATED [GOC:bf]
synonym: "G-CSF receptor activity" EXACT [GOC:bf]
synonym: "granulocyte colony stimulating factor receptor activity" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004903
name: growth hormone receptor activity
namespace: molecular_function
def: "Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004904
name: interferon receptor activity
namespace: molecular_function
def: "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:9607096]
synonym: "IFN receptor activity" EXACT [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004905
name: type I interferon receptor activity
namespace: molecular_function
def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon-alpha receptor activity" NARROW []
synonym: "interferon-alpha/beta receptor activity" NARROW []
synonym: "interferon-beta receptor activity" NARROW []
synonym: "interferon-delta receptor activity" NARROW []
synonym: "interferon-epsilon receptor activity" NARROW []
synonym: "interferon-kappa receptor activity" NARROW []
synonym: "interferon-omega receptor activity" NARROW []
synonym: "interferon-tau receptor activity" NARROW []
synonym: "interferon-zeta receptor activity" NARROW []
synonym: "type I IFN receptor activity" EXACT [GOC:mah]
is_a: GO:0004904 ! interferon receptor activity

[Term]
id: GO:0004906
name: type II interferon receptor activity
namespace: molecular_function
def: "Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383]
synonym: "IFN-gamma receptor activity" EXACT [GOC:mah]
synonym: "IFNG receptor activity" EXACT [GOC:mah]
synonym: "interferon-gamma receptor activity" EXACT []
is_a: GO:0004904 ! interferon receptor activity

[Term]
id: GO:0004908
name: interleukin-1 receptor activity
namespace: molecular_function
def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl]
synonym: "IL-1 receptor activity" EXACT []
synonym: "IL-1R" EXACT []
xref: Wikipedia:Interleukin-1_receptor
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004909
name: interleukin-1, type I, activating receptor activity
namespace: molecular_function
alt_id: GO:0019967
def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828]
synonym: "IL-1 type I, activating binding" EXACT []
synonym: "IL-1 type I, activating receptor" EXACT []
synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1 type I receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1, type I, activating binding" RELATED []
is_a: GO:0004908 ! interleukin-1 receptor activity

[Term]
id: GO:0004910
name: interleukin-1, type II, blocking receptor activity
namespace: molecular_function
alt_id: GO:0019968
def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828]
synonym: "IL-1 type II, blocking binding" EXACT []
synonym: "IL-1 type II, blocking receptor" EXACT []
synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1 type II receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1, type II, blocking binding" RELATED []
is_a: GO:0004908 ! interleukin-1 receptor activity

[Term]
id: GO:0004911
name: interleukin-2 receptor activity
namespace: molecular_function
def: "Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-2 receptor activity" EXACT [GOC:mah]
synonym: "IL-2R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004912
name: interleukin-3 receptor activity
namespace: molecular_function
def: "Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-3 receptor activity" EXACT [GOC:mah]
synonym: "IL-3R" EXACT []
xref: Wikipedia:Interleukin-3_receptor
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004913
name: interleukin-4 receptor activity
namespace: molecular_function
def: "Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-4 receptor activity" EXACT [GOC:mah]
synonym: "IL-4R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004914
name: interleukin-5 receptor activity
namespace: molecular_function
def: "Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-5 receptor activity" EXACT [GOC:mah]
synonym: "IL-5R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004915
name: interleukin-6 receptor activity
namespace: molecular_function
def: "Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "gp130" RELATED []
synonym: "IL-6 receptor activity" EXACT [GOC:mah]
synonym: "IL-6R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004917
name: interleukin-7 receptor activity
namespace: molecular_function
def: "Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-7 receptor activity" EXACT [GOC:mah]
synonym: "IL-7R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004918
name: interleukin-8 receptor activity
namespace: molecular_function
def: "Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-8 receptor activity" EXACT [GOC:mah]
synonym: "IL-8R" EXACT []
is_a: GO:0016494 ! C-X-C chemokine receptor activity

[Term]
id: GO:0004919
name: interleukin-9 receptor activity
namespace: molecular_function
def: "Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-9 receptor activity" EXACT [GOC:mah]
synonym: "IL-9R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004920
name: interleukin-10 receptor activity
namespace: molecular_function
def: "Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-10 receptor activity" EXACT [GOC:mah]
synonym: "IL-10R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004921
name: interleukin-11 receptor activity
namespace: molecular_function
def: "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "gp130" RELATED []
synonym: "IL-11 receptor activity" EXACT [GOC:mah]
synonym: "IL-11R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004923
name: leukemia inhibitory factor receptor activity
namespace: molecular_function
alt_id: GO:0004899
def: "Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:mah, GOC:signaling]
synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah]
synonym: "LIF receptor activity" EXACT [GOC:mah]
is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity

[Term]
id: GO:0004924
name: oncostatin-M receptor activity
namespace: molecular_function
def: "Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004925
name: prolactin receptor activity
namespace: molecular_function
def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004927
name: obsolete sevenless receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a gene product rather than an activity.
synonym: "sevenless receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0004888
consider: GO:0008288

[Term]
id: GO:0004928
name: obsolete frizzled receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product rather than an activity.
synonym: "frizzled receptor activity" EXACT []
is_obsolete: true
replaced_by: GO:0042813
consider: GO:0016055

[Term]
id: GO:0004929
name: obsolete frizzled-2 receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product rather than an activity.
synonym: "frizzled-2 receptor activity" EXACT []
is_obsolete: true
replaced_by: GO:0042813
consider: GO:0007223

[Term]
id: GO:0004930
name: G protein-coupled receptor activity
namespace: molecular_function
alt_id: GO:0001622
alt_id: GO:0001623
alt_id: GO:0001624
alt_id: GO:0001625
alt_id: GO:0016526
def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, Wikipedia:GPCR]
subset: goslim_chembl
synonym: "EBV-induced receptor" NARROW []
synonym: "Epstein-Barr Virus-induced receptor activity" NARROW []
synonym: "G protein coupled receptor activity" EXACT []
synonym: "G protein linked receptor activity" EXACT []
synonym: "G-protein coupled receptor activity" EXACT []
synonym: "G-protein coupled receptor activity, unknown ligand" NARROW []
synonym: "G-protein linked receptor activity" EXACT []
synonym: "GPCR activity" EXACT []
synonym: "ligand-dependent GPCR activity" EXACT []
synonym: "Mas proto-oncogene receptor activity" NARROW []
synonym: "orphan G protein coupled receptor activity" NARROW []
synonym: "orphan G-protein coupled receptor activity" NARROW []
synonym: "orphan GPCR activity" NARROW []
synonym: "RDC1 receptor activity" NARROW []
synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "SREB receptor" NARROW []
synonym: "super conserved receptor expressed in brain receptor activity" NARROW []
xref: Reactome:R-HSA-114552 "Thrombin-activated PARs activate G12/13"
xref: Reactome:R-HSA-114558 "Thrombin-activated PARs activate Gq"
xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein"
xref: Reactome:R-HSA-381706 "GLP1R:GLP1 activates G(s)"
xref: Wikipedia:GPCR
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0004931
name: extracellularly ATP-gated monoatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:bf, GOC:mah, PMID:9755289]
comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
synonym: "extracellularly ATP-gated cation channel activity" BROAD []
synonym: "P2X receptor" RELATED [PMID:9755289]
synonym: "purinoceptor" BROAD []
synonym: "purinoreceptor" BROAD []
xref: Reactome:R-HSA-877187 "P2X7 mediates loss of intracellular K+"
is_a: GO:0005231 ! excitatory extracellular ligand-gated monoatomic ion channel activity
is_a: GO:0035381 ! ATP-gated ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0004932
name: mating-type factor pheromone receptor activity
namespace: molecular_function
def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph, GOC:vw]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity
is_a: GO:0016503 ! pheromone receptor activity

[Term]
id: GO:0004933
name: mating-type a-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah]
synonym: "class D G protein coupled receptor activity" BROAD []
synonym: "class D G-protein coupled receptor activity" BROAD []
synonym: "class D G-protein-coupled receptor activity" BROAD []
synonym: "class D GPCR activity" BROAD []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity

[Term]
id: GO:0004934
name: mating-type alpha-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah]
synonym: "class D G protein coupled receptor activity" BROAD []
synonym: "class D G-protein coupled receptor activity" BROAD []
synonym: "class D G-protein-coupled receptor activity" BROAD []
synonym: "class D GPCR activity" BROAD []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity

[Term]
id: GO:0004935
name: adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
synonym: "adrenoceptor activity" EXACT []
xref: Wikipedia:Adrenergic_receptor
is_a: GO:0008227 ! G protein-coupled amine receptor activity

[Term]
id: GO:0004936
name: alpha-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha adrenoceptor" EXACT []
is_a: GO:0004935 ! adrenergic receptor activity

[Term]
id: GO:0004937
name: alpha1-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha1 adrenoceptor" EXACT []
is_a: GO:0004936 ! alpha-adrenergic receptor activity

[Term]
id: GO:0004938
name: alpha2-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha2 adrenoceptor" EXACT []
xref: Reactome:R-HSA-400071 "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline"
is_a: GO:0004936 ! alpha-adrenergic receptor activity

[Term]
id: GO:0004939
name: beta-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta adrenoceptor" EXACT []
is_a: GO:0004935 ! adrenergic receptor activity

[Term]
id: GO:0004940
name: beta1-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta1 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0004941
name: beta2-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta2 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0004945
name: angiotensin type II receptor activity
namespace: molecular_function
def: "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms." [GOC:mah, PMID:10977869]
is_a: GO:0001595 ! angiotensin receptor activity

[Term]
id: GO:0004946
name: bombesin receptor activity
namespace: molecular_function
def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004947
name: bradykinin receptor activity
namespace: molecular_function
def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004948
name: calcitonin receptor activity
namespace: molecular_function
def: "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645]
is_a: GO:0097642 ! calcitonin family receptor activity

[Term]
id: GO:0004949
name: cannabinoid receptor activity
namespace: molecular_function
def: "Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid]
synonym: "cannaboid receptor" EXACT []
synonym: "endocannabinoid receptor activity" NARROW [GOC:bf]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0004950
name: chemokine receptor activity
namespace: molecular_function
def: "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823, Wikipedia:Chemokine]
is_a: GO:0001637 ! G protein-coupled chemoattractant receptor activity
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004951
name: cholecystokinin receptor activity
namespace: molecular_function
def: "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone." [GOC:signaling, PMID:9835394]
synonym: "CCK receptor activity" EXACT [PR:000005110, Wikipedia:Cholecystokinin]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004952
name: dopamine neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983]
is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity

[Term]
id: GO:0004953
name: icosanoid receptor activity
namespace: molecular_function
def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph]
synonym: "eicosanoid receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0004954
name: prostanoid receptor activity
namespace: molecular_function
def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732]
is_a: GO:0004953 ! icosanoid receptor activity

[Term]
id: GO:0004955
name: prostaglandin receptor activity
namespace: molecular_function
def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732]
is_a: GO:0004954 ! prostanoid receptor activity

[Term]
id: GO:0004956
name: prostaglandin D receptor activity
namespace: molecular_function
def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGD receptor activity" RELATED []
synonym: "PGD(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004957
name: prostaglandin E receptor activity
namespace: molecular_function
def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGE receptor activity" RELATED []
synonym: "PGE(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004958
name: prostaglandin F receptor activity
namespace: molecular_function
def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGF receptor activity" RELATED []
synonym: "PGF(2-alpha) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004960
name: thromboxane receptor activity
namespace: molecular_function
def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "TXA receptor activity" EXACT []
is_a: GO:0004954 ! prostanoid receptor activity

[Term]
id: GO:0004961
name: thromboxane A2 receptor activity
namespace: molecular_function
def: "Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:signaling, ISBN:0198506732]
synonym: "TXA(2) receptor activity" EXACT []
synonym: "TXA2 receptor activity" EXACT [PMID:15242977]
is_a: GO:0004960 ! thromboxane receptor activity

[Term]
id: GO:0004962
name: endothelin receptor activity
namespace: molecular_function
alt_id: GO:0001599
alt_id: GO:0001600
def: "Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265]
synonym: "endothelin-A receptor activity" NARROW [GOC:bf, PMID:8582288]
synonym: "endothelin-B receptor activity" NARROW [GOC:bf, PMID:8582288]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004963
name: follicle-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "follicle stimulating hormone receptor activity" EXACT []
synonym: "FSH receptor activity" EXACT []
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004964
name: luteinizing hormone receptor activity
namespace: molecular_function
alt_id: GO:0004976
def: "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732, PMID:18848524, PMID:1922095]
synonym: "LH receptor" EXACT [PMID:18848524]
synonym: "LHR" EXACT [PMID:18848524]
synonym: "lutropin receptor" EXACT [ISBN:0198506732]
synonym: "lutropin-choriogonadotropic hormone receptor" RELATED [PMID:1922095]
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004965
name: G protein-coupled GABA receptor activity
namespace: molecular_function
def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]
synonym: "G-protein coupled GABA receptor activity" EXACT []
synonym: "GABA-B receptor activity" RELATED [GOC:bf]
synonym: "metabotropic GABA receptor" RELATED [Wikipedia:GABAB_receptor]
xref: Reactome:R-HSA-1013012 "Binding of Gbeta/gamma to GIRK/Kir3 channels"
xref: Reactome:R-HSA-1013013 "Association of GABA B receptor with G protein beta-gamma subunits"
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016917 ! GABA receptor activity

[Term]
id: GO:0004966
name: galanin receptor activity
namespace: molecular_function
def: "Combining with galanin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004967
name: glucagon receptor activity
namespace: molecular_function
def: "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:22438981]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004968
name: gonadotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:mah]
synonym: "GnRH receptor activity" EXACT []
synonym: "gonadotrophin-releasing hormone receptor activity" EXACT [GOC:dph]
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004969
name: histamine receptor activity
namespace: molecular_function
def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0008227 ! G protein-coupled amine receptor activity

[Term]
id: GO:0004970
name: glutamate-gated receptor activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'.
synonym: "ionotropic glutamate receptor activity" EXACT []
is_a: GO:0008066 ! glutamate receptor activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0004971
name: AMPA glutamate receptor activity
namespace: molecular_function
def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT []
synonym: "AMPA receptor activity" EXACT []
is_a: GO:0004970 ! glutamate-gated receptor activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0004972
name: NMDA glutamate receptor activity
namespace: molecular_function
def: "A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages." [GOC:mah, PMID:10049997, PMID:7790891]
comment: The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
synonym: "N-methyl-D-aspartate selective glutamate receptor activity" EXACT []
synonym: "NMDA receptor" EXACT []
xref: Wikipedia:NMDA_receptor
is_a: GO:0004970 ! glutamate-gated receptor activity
is_a: GO:0005244 ! voltage-gated monoatomic ion channel activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0004973
name: obsolete N-methyl-D-aspartate receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "N-methyl-D-aspartate receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0004974
name: leukotriene receptor activity
namespace: molecular_function
def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732]
is_a: GO:0004953 ! icosanoid receptor activity

[Term]
id: GO:0004977
name: melanocortin receptor activity
namespace: molecular_function
def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004978
name: corticotropin receptor activity
namespace: molecular_function
def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai]
synonym: "ACTH receptor activity" EXACT []
synonym: "adrenocorticotropic hormone receptor activity" EXACT []
synonym: "adrenocorticotropin receptor activity" EXACT []
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004979
name: beta-endorphin receptor activity
namespace: molecular_function
def: "Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)." [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin]
synonym: "mu-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0004985 ! G protein-coupled opioid receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004980
name: melanocyte-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459]
synonym: "melanocyte stimulating hormone receptor activity" EXACT []
synonym: "melanophore-stimulating hormone receptor activity" EXACT []
synonym: "MSH receptor activity" BROAD []
synonym: "MSHR activity" BROAD []
is_a: GO:0004977 ! melanocortin receptor activity

[Term]
id: GO:0004982
name: N-formyl peptide receptor activity
namespace: molecular_function
def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai]
synonym: "Fmet-leu-phe receptor" EXACT []
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004983
name: neuropeptide Y receptor activity
namespace: molecular_function
def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004984
name: olfactory receptor activity
namespace: molecular_function
def: "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
synonym: "odorant receptor activity" EXACT [PMID:19135896, PMID:21041441]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0004985
name: G protein-coupled opioid receptor activity
namespace: molecular_function
def: "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:20494127]
synonym: "opioid receptor activity" BROAD []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0004986
name: obsolete delta-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands." [IUPHAR_RECEPTOR:317, PMID:10471416]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "delta-opioid receptor activity" EXACT []
xref: Wikipedia:Delta_Opioid_receptor
is_obsolete: true
consider: GO:0038046

[Term]
id: GO:0004987
name: obsolete kappa-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins." [IUPHAR_RECEPTOR:318]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "kappa-opioid receptor activity" EXACT []
xref: Wikipedia:Kappa_Opioid_receptor
is_obsolete: true
consider: GO:0038048

[Term]
id: GO:0004988
name: obsolete mu-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins." [IUPHAR_RECEPTOR:319]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "mu-opioid receptor activity" EXACT []
xref: Wikipedia:Mu_Opioid_receptor
is_obsolete: true
consider: GO:0004979
consider: GO:0038046
consider: GO:0038047

[Term]
id: GO:0004989
name: octopamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai]
is_a: GO:0008227 ! G protein-coupled amine receptor activity

[Term]
id: GO:0004990
name: oxytocin receptor activity
namespace: molecular_function
def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004991
name: parathyroid hormone receptor activity
namespace: molecular_function
def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0004992
name: platelet activating factor receptor activity
namespace: molecular_function
def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah]
synonym: "PAF receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0004993
name: G protein-coupled serotonin receptor activity
namespace: molecular_function
alt_id: GO:0001585
alt_id: GO:0016609
def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]
synonym: "5-HT receptor" EXACT []
synonym: "5-hydroxytryptamine receptor" EXACT []
synonym: "G protein coupled serotonin receptor activity" EXACT []
synonym: "G-protein coupled serotonin receptor activity" EXACT []
xref: Wikipedia:5-HT_receptor
is_a: GO:0008227 ! G protein-coupled amine receptor activity

[Term]
id: GO:0004994
name: somatostatin receptor activity
namespace: molecular_function
def: "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)." [GOC:ai, GOC:bf, Wikipedia:Somatostatin]
synonym: "GHIH receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "growth hormone-inhibiting hormone receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "somatotrophin release inhibiting factor receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "SRIF receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "SST receptor activity" EXACT [Wikipedia:Somatostatin]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004995
name: tachykinin receptor activity
namespace: molecular_function
def: "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004996
name: thyroid-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "thyroid stimulating hormone receptor activity" EXACT []
synonym: "thyrotropin receptor" EXACT []
synonym: "TSH receptor activity" EXACT []
xref: Wikipedia:Thyrotropin_receptor
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004997
name: thyrotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0004998
name: transferrin receptor activity
namespace: molecular_function
def: "Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates." [GOC:bf, PMID:2678449, PMID:3011819]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0004999
name: vasoactive intestinal polypeptide receptor activity
namespace: molecular_function
def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0005000
name: vasopressin receptor activity
namespace: molecular_function
alt_id: GO:0016931
def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW []
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0005001
name: transmembrane receptor protein tyrosine phosphatase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [PMID:34353440]
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity

[Term]
id: GO:0005003
name: ephrin receptor activity
namespace: molecular_function
def: "Combining with an ephrin receptor ligand to initiate a change in cell activity." [GOC:mah, PMID:9530499]
synonym: "Eph receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005004
name: GPI-linked ephrin receptor activity
namespace: molecular_function
def: "Combining with a GPI-anchored ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]
synonym: "GPI-linked Eph receptor activity" EXACT []
is_a: GO:0005003 ! ephrin receptor activity

[Term]
id: GO:0005005
name: transmembrane-ephrin receptor activity
namespace: molecular_function
def: "Combining with a transmembrane ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]
synonym: "transmembrane-Eph receptor activity" EXACT []
is_a: GO:0005003 ! ephrin receptor activity

[Term]
id: GO:0005006
name: epidermal growth factor receptor activity
namespace: molecular_function
alt_id: GO:0005023
def: "Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf]
synonym: "EGF receptor activity" EXACT []
synonym: "EGFR" EXACT []
synonym: "epidermal growth factor-activated receptor activity" EXACT []
synonym: "TGF-alpha receptor activity" EXACT []
synonym: "transforming growth factor-alpha receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005007
name: fibroblast growth factor receptor activity
namespace: molecular_function
def: "Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "FGF receptor activity" EXACT []
synonym: "FGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "FGFR" EXACT []
synonym: "fibroblast growth factor-activated receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005008
name: hepatocyte growth factor receptor activity
namespace: molecular_function
def: "Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "hepatocyte growth factor-activated receptor activity" EXACT []
synonym: "HGF receptor activity" EXACT []
synonym: "HGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005009
name: insulin receptor activity
namespace: molecular_function
def: "Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732]
synonym: "insulin-activated receptor activity" EXACT []
xref: Reactome:R-HSA-74715 "Autophosphorylation of insulin receptor"
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0005010
name: insulin-like growth factor receptor activity
namespace: molecular_function
def: "Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "IGF receptor activity" EXACT []
synonym: "IGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "insulin-like growth factor-activated receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005011
name: macrophage colony-stimulating factor receptor activity
namespace: molecular_function
def: "Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:mah, GOC:signaling]
synonym: "CSF-1" NARROW []
synonym: "Fms" NARROW []
synonym: "M-CSF receptor activity" EXACT [GOC:bf]
synonym: "macrophage colony stimulating factor receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005012
name: obsolete Neu/ErbB-2 receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a class of receptor rather than an activity.
synonym: "Neu/ErbB-2 receptor activity" EXACT []
is_obsolete: true
consider: GO:0043125

[Term]
id: GO:0005013
name: obsolete neurotrophin TRK receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRK receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0019838
consider: GO:0043121

[Term]
id: GO:0005014
name: obsolete neurotrophin TRKA receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRKA receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0043121
consider: GO:0048406

[Term]
id: GO:0005015
name: obsolete neurotrophin TRKB receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRKB receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0043121
consider: GO:0048403

[Term]
id: GO:0005016
name: obsolete neurotrophin TRKC receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRKC receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0043121

[Term]
id: GO:0005017
name: platelet-derived growth factor receptor activity
namespace: molecular_function
def: "Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "PDGF receptor activity" EXACT []
synonym: "PDGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "PDGFR activity" EXACT []
synonym: "platelet-derived growth factor-activated receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005018
name: platelet-derived growth factor alpha-receptor activity
namespace: molecular_function
def: "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917]
synonym: "alphaPDGF receptor activity" EXACT [PMID:10372961]
synonym: "PDGF alpha-receptor activity" EXACT []
is_a: GO:0005017 ! platelet-derived growth factor receptor activity

[Term]
id: GO:0005019
name: platelet-derived growth factor beta-receptor activity
namespace: molecular_function
def: "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917]
synonym: "betaPDGF receptor activity" RELATED [PMID:10372961]
synonym: "PDGF beta-receptor activity" EXACT []
is_a: GO:0005017 ! platelet-derived growth factor receptor activity

[Term]
id: GO:0005020
name: stem cell factor receptor activity
namespace: molecular_function
def: "Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation." [GOC:jl, GOC:signaling, PMID:10698217]
synonym: "KIT" RELATED [PR:000009345]
synonym: "KIT ligand receptor activity" EXACT [PR:000009345]
synonym: "KL receptor activity" EXACT [PR:000009345]
synonym: "SCF receptor activity" EXACT [PR:000009345]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005021
name: vascular endothelial growth factor receptor activity
namespace: molecular_function
alt_id: GO:0036326
alt_id: GO:0036327
alt_id: GO:0036328
alt_id: GO:0036329
alt_id: GO:0036330
def: "Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:19909239]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "vascular endothelial growth factor E-activated receptor activity" EXACT [PMID:19909239]
synonym: "vascular endothelial growth factor-activated receptor activity" EXACT []
synonym: "VEGF receptor activity" EXACT []
synonym: "VEGF-A-activated receptor activity" NARROW []
synonym: "VEGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "VEGF-B-activated receptor activity" NARROW []
synonym: "VEGF-C-activated receptor activity" NARROW []
synonym: "VEGF-D-activated receptor activity" NARROW []
synonym: "VEGF-E-activated receptor activity" NARROW []
synonym: "VEGFR activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005024
name: transforming growth factor beta receptor activity
namespace: molecular_function
def: "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "TGF-beta receptor activity" EXACT []
synonym: "TGFbeta receptor activity" EXACT []
synonym: "TGFbeta-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "TGFbetaR" EXACT []
synonym: "transforming growth factor beta-activated receptor activity" EXACT []
is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity

[Term]
id: GO:0005025
name: transforming growth factor beta receptor activity, type I
namespace: molecular_function
def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah]
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "type I TGF-beta receptor activity" EXACT []
synonym: "type I TGFbeta receptor activity" EXACT []
synonym: "type I transforming growth factor beta receptor activity" EXACT []
is_a: GO:0005024 ! transforming growth factor beta receptor activity

[Term]
id: GO:0005026
name: transforming growth factor beta receptor activity, type II
namespace: molecular_function
def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah]
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "type II TGF-beta receptor activity" EXACT []
synonym: "type II TGFbeta receptor activity" EXACT []
synonym: "type II transforming growth factor beta receptor activity" EXACT []
xref: Reactome:R-HSA-170843 "TGFBR2 phosphorylates TGFBR1"
is_a: GO:0005024 ! transforming growth factor beta receptor activity

[Term]
id: GO:0005027
name: obsolete NGF/TNF (6 C-domain) receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a protein family rather than a molecular function.
synonym: "NGF/TNF (6 C-domain) receptor activity" EXACT []
is_obsolete: true
consider: GO:0005031

[Term]
id: GO:0005028
name: obsolete CD40 receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
synonym: "CD40 receptor activity" EXACT []
is_obsolete: true
consider: GO:0042615

[Term]
id: GO:0005029
name: obsolete CD27 receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
synonym: "CD27 receptor activity" EXACT []
is_obsolete: true
consider: GO:0042614

[Term]
id: GO:0005030
name: neurotrophin receptor activity
namespace: molecular_function
def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0005031
name: tumor necrosis factor receptor activity
namespace: molecular_function
alt_id: GO:0005032
alt_id: GO:0005033
def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/]
synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW []
synonym: "TNF receptor activity" EXACT []
synonym: "TNF receptor activity, type I" NARROW []
synonym: "TNF receptor activity, type II" NARROW []
synonym: "tumor necrosis factor receptor activity, type I" NARROW []
synonym: "tumor necrosis factor receptor activity, type II" NARROW []
synonym: "tumor necrosis factor-activated receptor activity" EXACT []
is_a: GO:0005035 ! death receptor activity

[Term]
id: GO:0005034
name: osmosensor activity
namespace: molecular_function
def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb]
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0005035
name: death receptor activity
namespace: molecular_function
def: "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]
synonym: "apoptosis-activating receptor activity" RELATED [GOC:bf]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0005037
name: obsolete death receptor adaptor protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "death receptor adaptor protein activity" EXACT []
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005038
name: obsolete death receptor interacting protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "death receptor interacting protein activity" EXACT []
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005039
name: obsolete death receptor-associated factor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "death receptor-associated factor activity" EXACT []
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005041
name: low-density lipoprotein particle receptor activity
namespace: molecular_function
alt_id: GO:0008032
def: "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis." [GOC:bf, ISBN:0198506732]
synonym: "LDL receptor" EXACT []
synonym: "LDLR activity" EXACT [GOC:bf]
synonym: "low-density lipoprotein receptor activity" RELATED []
xref: Reactome:R-HSA-2404131 "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol"
xref: Reactome:R-HSA-2424254 "LDLR transports extracellular CR:atREs to cytosol"
xref: Wikipedia:LDL_receptor
is_a: GO:0030228 ! lipoprotein particle receptor activity

[Term]
id: GO:0005042
name: netrin receptor activity
namespace: molecular_function
def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:dph, GOC:signaling, PMID:15960985]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0005043
name: netrin receptor activity involved in chemorepulsion
namespace: molecular_function
def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling]
synonym: "netrin receptor activity involved in negative chemotaxis" EXACT [GOC:bf]
synonym: "repulsive netrin receptor activity" EXACT [GOC:bf]
is_a: GO:0005042 ! netrin receptor activity

[Term]
id: GO:0005044
name: scavenger receptor activity
namespace: molecular_function
def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.
subset: goslim_chembl
synonym: "macrophage receptor activity" NARROW []
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0005045
name: obsolete endoplasmic reticulum receptor activity
namespace: molecular_function
def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai]
comment: This term was made obsolete because it represents cellular component and molecular function information.
synonym: "endoplasmic reticulum receptor activity" EXACT []
is_obsolete: true
consider: GO:0038024

[Term]
id: GO:0005046
name: KDEL sequence binding
namespace: molecular_function
def: "Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai]
synonym: "KDEL receptor activity" NARROW []
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0005047
name: signal recognition particle binding
namespace: molecular_function
def: "Binding to a signal recognition particle." [ISBN:0198506732]
comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'.
synonym: "docking protein" BROAD []
synonym: "signal recognition particle receptor" NARROW []
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0005048
name: signal sequence binding
namespace: molecular_function
alt_id: GO:0008249
def: "Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]
synonym: "leader sequence binding" NARROW []
synonym: "protein signal sequence binding" NARROW []
synonym: "signal sequence receptor" NARROW []
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0005049
name: nuclear export signal receptor activity
namespace: molecular_function
alt_id: GO:0008262
def: "Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]
synonym: "exportin activity" RELATED []
synonym: "importin-alpha binding" RELATED []
synonym: "importin-alpha export receptor activity" NARROW [GO:0008262]
synonym: "NES receptor" EXACT []
xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol"
is_a: GO:0140142 ! nucleocytoplasmic carrier activity

[Term]
id: GO:0005050
name: obsolete peroxisome receptor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular component.
synonym: "peroxisome receptor" EXACT []
is_obsolete: true
consider: GO:0005777
consider: GO:0038023

[Term]
id: GO:0005052
name: peroxisome matrix targeting signal-1 binding
namespace: molecular_function
def: "Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502]
synonym: "peroxisomal targeting signal 1 (PTS1) binding" EXACT [PMID:14709540]
synonym: "peroxisome targeting signal-1 binding" EXACT []
synonym: "peroxisome targeting signal-1 receptor" NARROW []
synonym: "PEX5" NARROW []
synonym: "PTS1 binding" EXACT [PMID:14709540]
synonym: "PTS1 receptor" NARROW []
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0005053
name: peroxisome matrix targeting signal-2 binding
namespace: molecular_function
def: "Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502]
synonym: "peroxisomal targeting signal 2 (PTS2) binding" EXACT [PMID:14709540]
synonym: "peroxisome targeting signal-2 binding" EXACT []
synonym: "peroxisome targeting signal-2 receptor" NARROW []
synonym: "PEX7" NARROW []
synonym: "PTS2 binding" EXACT [PMID:14709540]
synonym: "PTS2 receptor" EXACT []
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0005054
name: obsolete peroxisome integral membrane receptor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular component.
synonym: "Pas20p" RELATED []
synonym: "peroxisome integral membrane receptor" EXACT []
is_obsolete: true
consider: GO:0038023

[Term]
id: GO:0005055
name: laminin receptor activity
namespace: molecular_function
def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
is_a: GO:0098631 ! cell adhesion mediator activity

[Term]
id: GO:0005056
name: tiggrin receptor activity
namespace: molecular_function
def: "Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:9521906]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0005057
name: obsolete signal transducer activity, downstream of receptor
namespace: molecular_function
def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]
comment: This term was obsoleted because it was not clearly defined.
synonym: "intracellular signal transducer activity" EXACT [GOC:bf]
synonym: "receptor signaling protein activity" EXACT []
synonym: "receptor signalling protein activity" EXACT []
is_obsolete: true

[Term]
id: GO:0005061
name: obsolete aryl hydrocarbon receptor nuclear translocator activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "aryl hydrocarbon receptor nuclear translocator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0005065
name: obsolete heterotrimeric G-protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a cellular component and not a molecular function.
synonym: "heterotrimeric G-protein" EXACT []
is_obsolete: true
replaced_by: GO:0005834

[Term]
id: GO:0005066
name: obsolete transmembrane receptor protein tyrosine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "transmembrane receptor protein tyrosine kinase signaling protein activity" EXACT []
synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0007169
consider: GO:0035556

[Term]
id: GO:0005068
name: transmembrane receptor protein tyrosine kinase adaptor activity
namespace: molecular_function
alt_id: GO:0005069
def: "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848]
synonym: "transmembrane receptor protein tyrosine kinase adaptor protein activity" EXACT []
synonym: "transmembrane receptor protein tyrosine kinase docking protein activity" RELATED []
is_a: GO:0030159 ! signaling receptor complex adaptor activity
is_a: GO:0030971 ! receptor tyrosine kinase binding

[Term]
id: GO:0005070
name: obsolete SH3/SH2 adaptor activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so]
comment: This term was obsoleted because molecular adaptors should be represented by the type of molecules they serve to adapt, and not by their domains.
synonym: "SH3/SH2 adaptor protein activity" NARROW []
is_obsolete: true

[Term]
id: GO:0005071
name: obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "transmembrane receptor protein serine/threonine kinase signaling protein activity" EXACT []
synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0007178
consider: GO:0035556

[Term]
id: GO:0005072
name: obsolete transforming growth factor beta receptor, cytoplasmic mediator activity
namespace: molecular_function
def: "OBSOLETE. Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd]
comment: This term was obsoleted because it is redundant with other terms.
synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT []
is_obsolete: true
consider: GO:0000981

[Term]
id: GO:0005073
name: obsolete common-partner SMAD protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it names a family of gene products.
synonym: "common-partner SMAD protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005074
name: obsolete inhibitory SMAD protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it names a family of gene products.
synonym: "inhibitory SMAD protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005075
name: obsolete pathway-specific SMAD protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a family of gene products.
synonym: "pathway-specific SMAD protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005076
name: obsolete receptor signaling protein serine/threonine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein serine/threonine kinase signaling protein activity" EXACT []
synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0035556

[Term]
id: GO:0005077
name: obsolete MAP-kinase anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "MAP-kinase anchor protein activity" EXACT []
synonym: "MAP-kinase anchoring activity" EXACT []
is_obsolete: true
consider: GO:0008104
consider: GO:0051019

[Term]
id: GO:0005078
name: MAP-kinase scaffold activity
namespace: molecular_function
def: "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336]
synonym: "MAP-kinase scaffold protein activity" EXACT []
is_a: GO:0035591 ! signaling adaptor activity

[Term]
id: GO:0005079
name: obsolete protein kinase A anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "A-kinase anchor protein activity" EXACT []
synonym: "AKAP activity" EXACT []
synonym: "protein kinase A anchoring activity" EXACT []
is_obsolete: true
consider: GO:0008104
consider: GO:0051018

[Term]
id: GO:0005080
name: protein kinase C binding
namespace: molecular_function
alt_id: GO:0072568
alt_id: GO:0072569
alt_id: GO:0097024
def: "Binding to protein kinase C." [GOC:jl]
synonym: "PKC alpha binding" EXACT []
synonym: "PKC binding" EXACT []
synonym: "PKC delta binding" EXACT [GOC:BHF, GOC:pr]
synonym: "PKC eta binding" EXACT [GOC:BHF, GOC:pr]
synonym: "protein kinase C alpha binding" NARROW []
synonym: "protein kinase C delta binding" NARROW []
synonym: "protein kinase C eta binding" NARROW []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0005081
name: obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein serine/threonine phosphatase signaling protein activity" EXACT []
synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0035556

[Term]
id: GO:0005082
name: obsolete receptor signaling protein tyrosine phosphatase signaling protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein tyrosine phosphatase signaling protein activity" EXACT []
synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0035556

[Term]
id: GO:0005085
name: guanyl-nucleotide exchange factor activity
namespace: molecular_function
alt_id: GO:0005086
alt_id: GO:0005087
alt_id: GO:0005088
alt_id: GO:0005089
alt_id: GO:0005090
alt_id: GO:0008321
alt_id: GO:0008433
alt_id: GO:0016219
alt_id: GO:0016220
alt_id: GO:0017034
alt_id: GO:0017112
alt_id: GO:0017132
alt_id: GO:0019839
alt_id: GO:0030676
def: "Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "ARF guanyl-nucleotide exchange factor activity" NARROW []
synonym: "cAMP-dependent guanyl-nucleotide exchange factor activity" NARROW []
synonym: "GDP-dissociation stimulator activity" EXACT []
synonym: "GDS" EXACT []
synonym: "GEF" EXACT []
synonym: "GNRP" NARROW []
synonym: "guanyl-nucleotide release factor activity" EXACT []
synonym: "guanyl-nucleotide releasing factor" EXACT []
synonym: "Rab guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Rac guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Ral guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Ran guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Rap guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Ras guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Rho guanine nucleotide exchange factor" EXACT []
synonym: "Rho guanyl-nucleotide exchange factor activity" NARROW []
synonym: "RhoGEF" EXACT []
synonym: "Sar guanyl-nucleotide exchange factor activity" NARROW []
xref: Reactome:R-HSA-109807 "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS"
xref: Reactome:R-HSA-109817 "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS"
xref: Reactome:R-HSA-114544 "p115-RhoGEF activation of RHOA"
xref: Reactome:R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP"
xref: Reactome:R-HSA-1225951 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)"
xref: Reactome:R-HSA-1225957 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)"
xref: Reactome:R-HSA-1250383 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4"
xref: Reactome:R-HSA-1250463 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers"
xref: Reactome:R-HSA-1250498 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers"
xref: Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers"
xref: Reactome:R-HSA-1433415 "Activation of RAC1"
xref: Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1"
xref: Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity"
xref: Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1"
xref: Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1"
xref: Reactome:R-HSA-171026 "Guanine nucleotide exchange on RAL"
xref: Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)"
xref: Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)"
xref: Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP"
xref: Reactome:R-HSA-186834 "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)"
xref: Reactome:R-HSA-187746 "RIT/RIN are activated"
xref: Reactome:R-HSA-194518 "RhoA is activated by nucleotide exchange and inhibits axonal growth"
xref: Reactome:R-HSA-2029445 "An unknown GEF exchanges GTP for GDP on CDC42:GDP"
xref: Reactome:R-HSA-2029451 "Activation of RAC1 by VAV"
xref: Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO"
xref: Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding"
xref: Reactome:R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor"
xref: Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)"
xref: Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)"
xref: Reactome:R-HSA-2424476 "Activation of RAC1 by VAV2/3"
xref: Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)"
xref: Reactome:R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt"
xref: Reactome:R-HSA-2730840 "Activation of RAC1 by VAV"
xref: Reactome:R-HSA-350769 "trans-Golgi Network Coat Activation"
xref: Reactome:R-HSA-354173 "Activation of Rap1 by cytosolic GEFs"
xref: Reactome:R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs"
xref: Reactome:R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11"
xref: Reactome:R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi"
xref: Reactome:R-HSA-389348 "Activation of Rac1 by pVav1"
xref: Reactome:R-HSA-389350 "Activation of Cdc42 by pVav1"
xref: Reactome:R-HSA-392054 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras"
xref: Reactome:R-HSA-392195 "Gi activation by P2Y purinoceptor 12"
xref: Reactome:R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it"
xref: Reactome:R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it"
xref: Reactome:R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it"
xref: Reactome:R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it"
xref: Reactome:R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it"
xref: Reactome:R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it"
xref: Reactome:R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA"
xref: Reactome:R-HSA-392870 "Gs activation by prostacyclin receptor"
xref: Reactome:R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange"
xref: Reactome:R-HSA-399938 "Activation of Rac1 by FARP2"
xref: Reactome:R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq"
xref: Reactome:R-HSA-400092 "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins"
xref: Reactome:R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it"
xref: Reactome:R-HSA-416530 "FFAR1:FFAR1 ligands activate Gq"
xref: Reactome:R-HSA-416588 "Activation of Rho by LARG and PDZ-RhoGEF"
xref: Reactome:R-HSA-418579 "Gq activation by P2Y purinoceptor 1"
xref: Reactome:R-HSA-418850 "Activation of Cdc42"
xref: Reactome:R-HSA-418856 "Activation of Rac1"
xref: Reactome:R-HSA-419166 "GEFs activate RhoA,B,C"
xref: Reactome:R-HSA-420883 "Opsins act as GEFs for G alpha-t"
xref: Reactome:R-HSA-428535 "Activation of RAC1 by SOS"
xref: Reactome:R-HSA-428750 "Gq activation by TP receptor"
xref: Reactome:R-HSA-428917 "G13 activation by TP receptor"
xref: Reactome:R-HSA-442273 "VAV1 is a GEF for Rho/Rac family GTPases"
xref: Reactome:R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases"
xref: Reactome:R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases"
xref: Reactome:R-HSA-442732 "NMDA-activated RASGRF1 activates RAS"
xref: Reactome:R-HSA-445064 "Activation of Rac1 by VAV2"
xref: Reactome:R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism"
xref: Reactome:R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1"
xref: Reactome:R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it"
xref: Reactome:R-HSA-5617816 "RAB3IP stimulates nucleotide exchange on RAB8A"
xref: Reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4"
xref: Reactome:R-HSA-5623521 "RAB3IP stimulates nucleotide exchange on RAB8A"
xref: Reactome:R-HSA-5637806 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)"
xref: Reactome:R-HSA-5637808 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)"
xref: Reactome:R-HSA-5654392 "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5654402 "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5654413 "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5654426 "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5654600 "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5654618 "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5654647 "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5654663 "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5655241 "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5655277 "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5655326 "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5655347 "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange"
xref: Reactome:R-HSA-5672965 "RAS GEFs promote RAS nucleotide exchange"
xref: Reactome:R-HSA-5686071 "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS"
xref: Reactome:R-HSA-5686318 "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS"
xref: Reactome:R-HSA-5694409 "Nucleotide exchange on RAB1"
xref: Reactome:R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange"
xref: Reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF"
xref: Reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane"
xref: Reactome:R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange"
xref: Reactome:R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz"
xref: Reactome:R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13"
xref: Reactome:R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange"
xref: Reactome:R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex"
xref: Reactome:R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18"
xref: Reactome:R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1"
xref: Reactome:R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET"
xref: Reactome:R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET"
xref: Reactome:R-HSA-8875318 "RAB3 GEFs exchange GTP for GDP on RAB3A"
xref: Reactome:R-HSA-8875320 "RAB5 GEFs exchange GTP for GDP on RAB5"
xref: Reactome:R-HSA-8875568 "RAPGEF1 activates RAP1"
xref: Reactome:R-HSA-8875591 "DOCK7 activates RAC1"
xref: Reactome:R-HSA-8876188 "DENND4s exchange GTP for GDP on RAB10"
xref: Reactome:R-HSA-8876190 "RAB8 GEFs exchange GTP for GDP on RAB8"
xref: Reactome:R-HSA-8876191 "RAB9 GEFs exchange GTP for GDP on RAB9"
xref: Reactome:R-HSA-8876193 "RIC1-RGP1 exchanges GTP for GDP on RAB6"
xref: Reactome:R-HSA-8876454 "DENND3 exchanges GTP for GDP on RAB12"
xref: Reactome:R-HSA-8876615 "RAB13 GEFs exchange GTP for GDP on RAB13"
xref: Reactome:R-HSA-8876616 "DENND6A,B exchange GTP for GDP on RAB14"
xref: Reactome:R-HSA-8876837 "RAB21 GEFs exchange GTP for GDP on RAB21"
xref: Reactome:R-HSA-8877308 "MADD exchanges GTP for GDP on RAB27"
xref: Reactome:R-HSA-8877311 "RAB31 GEFs exchange GTP for GDP on RAB31"
xref: Reactome:R-HSA-8877451 "MON1:CCZ1 exchanges GTP for GDP on RAB7"
xref: Reactome:R-HSA-8877475 "TRAPPC complexes exchange GTP for GDP on RAB1"
xref: Reactome:R-HSA-8877612 "DENND1s exchange GTP for GDP on RAB35"
xref: Reactome:R-HSA-8877760 "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38"
xref: Reactome:R-HSA-8877813 "DENND5A,B exchange GTP for GDP on RAB39"
xref: Reactome:R-HSA-8877998 "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18"
xref: Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated"
xref: Reactome:R-HSA-8980691 "RHOA GEFs activate RHOA"
xref: Reactome:R-HSA-8982637 "Opsins binds G alpha-t"
xref: Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)"
xref: Reactome:R-HSA-9013023 "RHOB GEFs activate RHOB"
xref: Reactome:R-HSA-9013109 "RHOC GEFs activate RHOC"
xref: Reactome:R-HSA-9013143 "RAC1 GEFs activate RAC1"
xref: Reactome:R-HSA-9013159 "CDC42 GEFs activate CDC42"
xref: Reactome:R-HSA-9013435 "RHOD auto-activates"
xref: Reactome:R-HSA-9014296 "RAC2 GEFs activate RAC2"
xref: Reactome:R-HSA-9014433 "RHOG GEFs activate RHOG"
xref: Reactome:R-HSA-9017491 "RHOJ GEFs activate RHOJ"
xref: Reactome:R-HSA-9018747 "RHOQ GEFs activate RHOQ"
xref: Reactome:R-HSA-9018768 "RHOU auto-activates"
xref: Reactome:R-HSA-9018804 "RAC3 GEFs activate RAC3"
xref: Reactome:R-HSA-9018817 "RHOT1 GEFs activate RHOT1"
xref: Reactome:R-HSA-9018825 "RHOT2 GEFs activate RHOT2"
xref: Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1"
xref: Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS"
xref: Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2"
xref: Reactome:R-HSA-9032798 "DOCK3 activates RAC1"
xref: Reactome:R-HSA-9033292 "NTRK2 and CDK5 promote activation of RAC1 by TIAM1"
xref: Reactome:R-HSA-9036301 "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s"
xref: Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs"
xref: Reactome:R-HSA-9607304 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3"
xref: Reactome:R-HSA-9619803 "p-S516-ARHGEF7 activates RAC1"
xref: Reactome:R-HSA-9624845 "RCC1 stimulates GDP to GTP exchange on RAN"
xref: Reactome:R-HSA-9634418 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1"
xref: Reactome:R-HSA-9639286 "RRAGC,D exchanges GTP for GDP"
xref: Reactome:R-HSA-9640167 "RRAGA,B exchanges GDP for GTP"
xref: Reactome:R-HSA-9660824 "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs"
xref: Reactome:R-HSA-9664991 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants"
xref: Reactome:R-HSA-9665009 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR"
xref: Reactome:R-HSA-9665404 "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1"
xref: Reactome:R-HSA-9665408 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2"
xref: Reactome:R-HSA-9665700 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants"
xref: Reactome:R-HSA-9665707 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR"
xref: Reactome:R-HSA-9666428 "DOCK180 exchanges GTP for GDP on RAC1:GDP"
xref: Reactome:R-HSA-9666430 "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP"
xref: Reactome:R-HSA-9670436 "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS"
xref: Reactome:R-HSA-9672163 "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers"
xref: Reactome:R-HSA-9672170 "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors"
xref: Reactome:R-HSA-9680385 "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS"
xref: Reactome:R-HSA-9693111 "RHOF auto-activates"
xref: Reactome:R-HSA-9695853 "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS"
xref: Reactome:R-HSA-9703441 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants"
xref: Reactome:R-HSA-9751201 "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1"
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005091
name: guanyl-nucleotide exchange factor adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]
is_a: GO:0030674 ! protein-macromolecule adaptor activity
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005092
name: GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]
synonym: "GDI" EXACT []
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005093
name: Rab GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah]
is_a: GO:0005092 ! GDP-dissociation inhibitor activity

[Term]
id: GO:0005094
name: Rho GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah]
is_a: GO:0005092 ! GDP-dissociation inhibitor activity

[Term]
id: GO:0005095
name: GTPase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai]
synonym: "GIP" BROAD []
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005096
name: GTPase activator activity
namespace: molecular_function
alt_id: GO:0005097
alt_id: GO:0005098
alt_id: GO:0005099
alt_id: GO:0005100
alt_id: GO:0005101
alt_id: GO:0008060
alt_id: GO:0017123
alt_id: GO:0030675
alt_id: GO:0046582
def: "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
comment: Note that the name Sar derives from 'secretion-associated, Ras-related'.
synonym: "ARF GAP activity" NARROW [GOC:pg]
synonym: "ARF GTPase activator activity" NARROW []
synonym: "GAP activity" EXACT []
synonym: "Rab GAP activity" NARROW [GOC:pg]
synonym: "Rab GTPase activator activity" NARROW []
synonym: "Rac GAP activity" NARROW [GOC:pg]
synonym: "Rac GTPase activator activity" NARROW []
synonym: "Ral GAP activity" NARROW [GOC:pg]
synonym: "Ral GTPase activator activity" NARROW []
synonym: "Ran GAP activity" NARROW [GOC:pg]
synonym: "Ran GTPase activator activity" NARROW []
synonym: "RanGAP" NARROW []
synonym: "Rap GAP activity" NARROW [GOC:pg]
synonym: "Rap GTPase activator activity" NARROW []
synonym: "Ras GAP activity" NARROW [GOC:pg]
synonym: "Ras GTPase activator activity" NARROW []
synonym: "Rho GAP activity" NARROW [GOC:pg]
synonym: "Rho GTPase activator activity" NARROW []
synonym: "Sar GAP activity" NARROW [GOC:pg]
synonym: "Sar GTPase activator activity" NARROW []
xref: Reactome:R-HSA-392513 "Rap1 signal termination by Rap1GAPs"
xref: Reactome:R-HSA-399935 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity"
xref: Reactome:R-HSA-4093339 "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it"
xref: Reactome:R-HSA-416546 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity"
xref: Reactome:R-HSA-416559 "Inactivation of Rho-GTP by p190RhoGAP"
xref: Reactome:R-HSA-428522 "Inactivation of RAC1"
xref: Reactome:R-HSA-428533 "Inactivation of CDC42"
xref: Reactome:R-HSA-5638007 "RP2 activates the GTPase activity of ARL3"
xref: Reactome:R-HSA-8981637 "RHOA GAPs stimulate RHOA GTPase activity"
xref: Reactome:R-HSA-8985594 "MYO9B inactivates RHOA"
xref: Reactome:R-HSA-9013022 "RHOB GAPs stimulate RHOB GTPase activity"
xref: Reactome:R-HSA-9013111 "RHOC GAPs stimulate RHOC GTPase activity"
xref: Reactome:R-HSA-9013144 "RAC1 GAPs stimulate RAC1 GTPase activity"
xref: Reactome:R-HSA-9013161 "CDC42 GAPs stimulate CDC42 GTPase activity"
xref: Reactome:R-HSA-9013437 "RHOD GAPs stimulate RHOD GTPase activity"
xref: Reactome:R-HSA-9014295 "RAC2 GAPs stimulate RAC2 GTPase activity"
xref: Reactome:R-HSA-9014434 "RHOG GAPs stimulate RHOG GTPase activity"
xref: Reactome:R-HSA-9017488 "RHOJ GAPs stimulate RHOJ GTPase activity"
xref: Reactome:R-HSA-9018745 "RHOQ GAPs stimulate RHOQ GTPase activity"
xref: Reactome:R-HSA-9018806 "RAC3 GAPs stimulate RAC3 GTPase activity"
xref: Reactome:R-HSA-9624893 "RAN stimulates fusion of nuclear envelope (NE) membranes"
xref: Reactome:R-HSA-9693282 "RHOF GAPs stimulate RHOF GTPase activity"
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005102
name: signaling receptor binding
namespace: molecular_function
def: "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_plant
synonym: "receptor binding" BROAD []
synonym: "receptor ligand" NARROW []
synonym: "receptor-associated protein activity" RELATED []
xref: Wikipedia:Ligand_(biochemistry)
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005104
name: fibroblast growth factor receptor binding
namespace: molecular_function
alt_id: GO:0001521
alt_id: GO:0005162
def: "Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]
comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor.
synonym: "FGF receptor binding" EXACT []
synonym: "FGFR binding" EXACT []
synonym: "FGFR ligand" NARROW []
synonym: "fibroblast growth factor" BROAD []
synonym: "fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005105
name: type 1 fibroblast growth factor receptor binding
namespace: molecular_function
def: "Binding to a type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators]
comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1).
synonym: "breathless binding" NARROW []
synonym: "breathless ligand" NARROW []
synonym: "FGFR1 binding" BROAD []
synonym: "FGFR1 ligand" NARROW []
synonym: "type 1 fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0005104 ! fibroblast growth factor receptor binding

[Term]
id: GO:0005106
name: obsolete ephrin
namespace: molecular_function
def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "ephrin" EXACT []
is_obsolete: true
consider: GO:0046875

[Term]
id: GO:0005107
name: obsolete GPI-linked ephrin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "GPI-linked ephrin" EXACT []
is_obsolete: true
consider: GO:0005886

[Term]
id: GO:0005108
name: obsolete transmembrane ephrin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "transmembrane ephrin" EXACT []
is_obsolete: true
consider: GO:0046875

[Term]
id: GO:0005109
name: frizzled binding
namespace: molecular_function
alt_id: GO:0005110
def: "Binding to a frizzled (fz) receptor." [GOC:ceb]
subset: goslim_chembl
synonym: "frizzled ligand" NARROW []
synonym: "frizzled-2 binding" NARROW []
synonym: "frizzled-2 ligand" NARROW []
synonym: "fz binding" EXACT []
synonym: "fz ligand" NARROW []
synonym: "fz2 binding" NARROW []
synonym: "fz2 ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0005111
name: type 2 fibroblast growth factor receptor binding
namespace: molecular_function
def: "Binding to a type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators]
comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2).
synonym: "FGFR2 binding" EXACT []
synonym: "FGFR2 ligand" NARROW []
synonym: "heartless binding" EXACT []
synonym: "heartless ligand" NARROW []
synonym: "type 2 fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0005104 ! fibroblast growth factor receptor binding

[Term]
id: GO:0005112
name: Notch binding
namespace: molecular_function
def: "Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]
synonym: "N binding" EXACT []
synonym: "N ligand" NARROW []
synonym: "Notch ligand" NARROW []
synonym: "Notch receptor binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005113
name: patched binding
namespace: molecular_function
def: "Binding to a patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473]
synonym: "patched ligand" NARROW []
synonym: "ptc binding" EXACT []
synonym: "ptc ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005114
name: type II transforming growth factor beta receptor binding
namespace: molecular_function
def: "Binding to a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892]
synonym: "punt binding" NARROW []
synonym: "punt ligand" NARROW []
synonym: "TGF-beta type II binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "transforming growth factor beta receptor type II binding" EXACT []
synonym: "type II TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0005115
name: receptor tyrosine kinase-like orphan receptor binding
namespace: molecular_function
def: "Binding to a receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb, GOC:vw]
synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW []
synonym: "Ror binding" BROAD []
synonym: "Ror ligand" RELATED []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005117
name: wishful thinking binding
namespace: molecular_function
def: "Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529]
synonym: "SE20 receptor binding" NARROW []
synonym: "wishful thinking ligand" NARROW []
synonym: "Wit binding" EXACT []
synonym: "Wit ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005118
name: sevenless binding
namespace: molecular_function
def: "Binding to a sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175]
synonym: "sev binding" EXACT []
synonym: "sev ligand" NARROW []
synonym: "sevenless ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005119
name: smoothened binding
namespace: molecular_function
def: "Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473]
synonym: "smo binding" EXACT []
synonym: "smo ligand" NARROW []
synonym: "smoothened ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0005121
name: Toll binding
namespace: molecular_function
def: "Binding to a Toll protein, a transmembrane receptor." [GOC:ceb]
synonym: "Tl binding" EXACT []
synonym: "Toll ligand" NARROW []
synonym: "Toll receptor binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005122
name: torso binding
namespace: molecular_function
def: "Binding to a torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509]
synonym: "tor binding" EXACT []
synonym: "tor ligand" NARROW []
synonym: "torso ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005123
name: death receptor binding
namespace: molecular_function
def: "Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015]
subset: goslim_chembl
synonym: "APO binding" NARROW [GOC:rl]
synonym: "death receptor adaptor protein activity" RELATED []
synonym: "death receptor interacting protein activity" RELATED []
synonym: "death receptor ligand" NARROW []
synonym: "death receptor-associated factor activity" RELATED []
synonym: "DR binding" NARROW [GOC:rl]
synonym: "EDAR binding" NARROW [GOC:rl]
synonym: "FAS binding" NARROW [GOC:rl]
synonym: "KILLER binding" NARROW [GOC:rl]
synonym: "NGFR binding" NARROW [GOC:rl]
synonym: "TNFR1 binding" NARROW [GOC:rl]
synonym: "TRAIL binding" NARROW [GOC:rl]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005124
name: scavenger receptor binding
namespace: molecular_function
def: "Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb]
synonym: "scavenger receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005125
name: cytokine activity
namespace: molecular_function
def: "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]
subset: goslim_chembl
synonym: "autocrine activity" RELATED [GOC:rl]
synonym: "paracrine activity" RELATED [GOC:rl]
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0005126
name: cytokine receptor binding
namespace: molecular_function
def: "Binding to a cytokine receptor." [GOC:mah, GOC:vw]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005127
name: ciliary neurotrophic factor receptor binding
namespace: molecular_function
def: "Binding to a ciliary neurotrophic factor receptor." [GOC:ai]
synonym: "ciliary neurotrophic factor" NARROW []
synonym: "ciliary neurotrophic factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005128
name: erythropoietin receptor binding
namespace: molecular_function
def: "Binding to an erythropoietin receptor." [GOC:ai]
synonym: "erythropoietin" NARROW []
synonym: "erythropoietin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005129
name: granulocyte macrophage colony-stimulating factor receptor binding
namespace: molecular_function
def: "Binding to a granulocyte macrophage colony-stimulating factor receptor." [GOC:ai]
synonym: "GM-CSF receptor binding" EXACT [GOC:vk]
synonym: "GM-CSF receptor ligand" NARROW []
synonym: "GMC-SF receptor ligand" NARROW []
synonym: "granulocyte macrophage colony stimulating factor receptor binding" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor" NARROW []
synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005130
name: granulocyte colony-stimulating factor receptor binding
namespace: molecular_function
def: "Binding to a granulocyte colony-stimulating factor receptor." [GOC:ai]
synonym: "G-CSF receptor ligand" EXACT []
synonym: "GC-SF receptor ligand" EXACT []
synonym: "granulocyte colony stimulating factor receptor binding" EXACT []
synonym: "granulocyte colony-stimulating factor" NARROW []
synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005131
name: growth hormone receptor binding
namespace: molecular_function
def: "Binding to a growth hormone receptor." [GOC:ai]
synonym: "growth hormone" NARROW []
synonym: "growth hormone receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0005132
name: type I interferon receptor binding
namespace: molecular_function
def: "Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:ai, GOC:signaling, PMID:17502368]
synonym: "IFNAR binding" RELATED [PMID:17502368]
synonym: "IFNAR1 binding" NARROW [PR:000008922]
synonym: "IFNAR2 binding" NARROW [PR:000008923]
synonym: "interferon-alpha/beta" NARROW []
synonym: "interferon-alpha/beta receptor binding" EXACT [PR:000008922, PR:000008923]
synonym: "interferon-alpha/beta receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0005133
name: type II interferon receptor binding
namespace: molecular_function
def: "Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma." [GOC:ai]
synonym: "interferon-gamma" NARROW []
synonym: "interferon-gamma receptor binding" EXACT []
synonym: "interferon-gamma receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005134
name: interleukin-2 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-2 receptor." [GOC:ai]
synonym: "IL-2" NARROW []
synonym: "interleukin-2 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005135
name: interleukin-3 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-3 receptor." [GOC:ai]
synonym: "IL-3" NARROW []
synonym: "interleukin-3 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005136
name: interleukin-4 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-4 receptor." [GOC:ai]
synonym: "IL-4" NARROW []
synonym: "interleukin-4 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005137
name: interleukin-5 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-5 receptor." [GOC:ai]
subset: goslim_chembl
synonym: "IL-5" NARROW []
synonym: "interleukin-5 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005138
name: interleukin-6 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-6 receptor." [GOC:ai]
subset: goslim_chembl
synonym: "IL-6" NARROW []
synonym: "interleukin-6 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005139
name: interleukin-7 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-7 receptor." [GOC:ai]
synonym: "IL-7" NARROW []
synonym: "interleukin-7 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005140
name: interleukin-9 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-9 receptor." [GOC:ai]
synonym: "IL-9" NARROW []
synonym: "interleukin-9 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005141
name: interleukin-10 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-10 receptor." [GOC:ai]
synonym: "IL-10" NARROW []
synonym: "interleukin-10 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005142
name: interleukin-11 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-11 receptor." [GOC:ai]
synonym: "IL-11" NARROW []
synonym: "interleukin-11 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005143
name: interleukin-12 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-12 receptor." [GOC:ai]
synonym: "IL-12" NARROW []
synonym: "interleukin-12 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005144
name: interleukin-13 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-13 receptor." [GOC:ai]
synonym: "IL-13" NARROW []
synonym: "interleukin-13 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005145
name: obsolete interleukin-14 receptor binding
namespace: molecular_function
def: "OBSOLETE. Binding to an interleukin-14 receptor." [GOC:ai]
comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
synonym: "IL-14" NARROW []
synonym: "interleukin-14 receptor ligand" NARROW []
is_obsolete: true

[Term]
id: GO:0005146
name: leukemia inhibitory factor receptor binding
namespace: molecular_function
def: "Binding to an leukemia inhibitory factor receptor." [GOC:ai]
synonym: "leukemia inhibitory factor" NARROW []
synonym: "leukemia inhibitory factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005147
name: oncostatin-M receptor binding
namespace: molecular_function
def: "Binding to an oncostatin-M receptor." [GOC:ai]
synonym: "oncostatin-M" NARROW []
synonym: "oncostatin-M receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005148
name: prolactin receptor binding
namespace: molecular_function
def: "Binding to a prolactin receptor." [GOC:ai]
synonym: "prolactin" NARROW []
synonym: "prolactin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005149
name: interleukin-1 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-1 receptor." [GOC:go_curators]
synonym: "IL-1" NARROW []
synonym: "interleukin-1 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005150
name: interleukin-1, type I receptor binding
namespace: molecular_function
def: "Binding to a Type I interleukin-1 receptor." [GOC:ai]
synonym: "IL-1 type I" NARROW []
synonym: "interleukin-1, type I receptor ligand" NARROW []
is_a: GO:0005149 ! interleukin-1 receptor binding

[Term]
id: GO:0005151
name: interleukin-1, type II receptor binding
namespace: molecular_function
def: "Binding to a Type II interleukin-1 receptor." [GOC:ai]
synonym: "IL-1 type II" NARROW []
synonym: "interleukin-1, type II receptor ligand" NARROW []
is_a: GO:0005149 ! interleukin-1 receptor binding

[Term]
id: GO:0005152
name: interleukin-1 receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc]
synonym: "IL-1ra" EXACT []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0019966 ! interleukin-1 binding
is_a: GO:0048019 ! receptor antagonist activity

[Term]
id: GO:0005153
name: interleukin-8 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-8 receptor." [GOC:go_curators]
subset: goslim_chembl
synonym: "IL-8" NARROW []
synonym: "interleukin-8 receptor ligand" NARROW []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0005154
name: epidermal growth factor receptor binding
namespace: molecular_function
alt_id: GO:0008185
def: "Binding to an epidermal growth factor receptor." [GOC:ai]
subset: goslim_chembl
synonym: "EGF" NARROW []
synonym: "EGF receptor binding" EXACT []
synonym: "EGF receptor ligand" NARROW []
synonym: "EGFR binding" EXACT []
synonym: "epidermal growth factor" NARROW []
synonym: "epidermal growth factor receptor ligand" NARROW []
synonym: "TGF-alpha receptor binding" EXACT []
synonym: "TGFalpha receptor binding" EXACT []
synonym: "transforming growth factor alpha" NARROW []
synonym: "transforming growth factor alpha receptor binding" EXACT []
synonym: "transforming growth factor alpha receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005155
name: obsolete epidermal growth factor receptor activating ligand activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it represents both a biological process and a molecular function.
synonym: "EGF receptor activating ligand activity" EXACT []
synonym: "EGFR activating ligand activity" EXACT []
synonym: "epidermal growth factor receptor activating ligand activity" EXACT []
is_obsolete: true
replaced_by: GO:0005154
consider: GO:0030297
consider: GO:0045741

[Term]
id: GO:0005156
name: obsolete epidermal growth factor receptor inhibiting ligand activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it represents both a biological process and a molecular function.
synonym: "EGF receptor inhibiting ligand activity" EXACT []
synonym: "EGFR inhibiting ligand activity" EXACT []
synonym: "epidermal growth factor receptor inhibiting ligand activity" EXACT []
is_obsolete: true
replaced_by: GO:0005154
consider: GO:0007175
consider: GO:0030293

[Term]
id: GO:0005157
name: macrophage colony-stimulating factor receptor binding
namespace: molecular_function
def: "Binding to a macrophage colony-stimulating factor receptor." [GOC:ai]
synonym: "M-CSF receptor binding" EXACT [GOC:vk]
synonym: "macrophage colony stimulating factor receptor binding" EXACT []
synonym: "macrophage colony-stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005158
name: insulin receptor binding
namespace: molecular_function
def: "Binding to an insulin receptor." [GOC:ai]
synonym: "insulin receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005159
name: insulin-like growth factor receptor binding
namespace: molecular_function
alt_id: GO:0005067
def: "Binding to an insulin-like growth factor receptor." [GOC:jl]
synonym: "IGF receptor binding" EXACT []
synonym: "insulin-like growth factor" NARROW []
synonym: "insulin-like growth factor receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005160
name: transforming growth factor beta receptor binding
namespace: molecular_function
def: "Binding to a transforming growth factor beta receptor." [GOC:ai]
synonym: "activin" RELATED []
synonym: "inhibin" RELATED []
synonym: "TGF-beta receptor binding" EXACT []
synonym: "TGFbeta receptor binding" EXACT []
synonym: "transforming growth factor beta" NARROW []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "transforming growth factor beta receptor anchoring activity" RELATED []
synonym: "transforming growth factor beta receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005161
name: platelet-derived growth factor receptor binding
namespace: molecular_function
def: "Binding to a platelet-derived growth factor receptor." [GOC:ai]
synonym: "PDGF" NARROW []
synonym: "PDGF receptor binding" EXACT []
synonym: "PDGFR binding" EXACT []
synonym: "platelet-derived growth factor" NARROW []
synonym: "platelet-derived growth factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005163
name: nerve growth factor receptor binding
namespace: molecular_function
def: "Binding to a nerve growth factor receptor." [GOC:ai, PMID:15654015]
synonym: "nerve growth factor receptor ligand" NARROW []
synonym: "neurotrophin" NARROW []
synonym: "NGF receptor binding" EXACT []
is_a: GO:0005123 ! death receptor binding
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005164
name: tumor necrosis factor receptor binding
namespace: molecular_function
def: "Binding to a tumor necrosis factor receptor." [GOC:ai]
subset: goslim_chembl
synonym: "TNF receptor binding" EXACT []
synonym: "tumor necrosis factor" NARROW []
synonym: "tumor necrosis factor receptor ligand" NARROW []
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005165
name: neurotrophin receptor binding
namespace: molecular_function
def: "Binding to a neurotrophin receptor." [GOC:ai]
synonym: "neurotrophin" NARROW []
synonym: "neurotrophin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005166
name: neurotrophin p75 receptor binding
namespace: molecular_function
def: "Binding to a neurotrophin p75 receptor." [GOC:ai]
synonym: "neurotrophin p75 receptor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005167
name: neurotrophin TRK receptor binding
namespace: molecular_function
def: "Binding to a neurotrophin TRK receptor." [GOC:ai]
synonym: "neurotrophin TRK receptor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005168
name: neurotrophin TRKA receptor binding
namespace: molecular_function
def: "Binding to a neurotrophin TRKA receptor." [GOC:ai]
synonym: "neurotrophin TRKA receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005169
name: neurotrophin TRKB receptor binding
namespace: molecular_function
def: "Binding to a neurotrophin TRKB receptor." [GOC:ai]
synonym: "neurotrophin TRKB receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005170
name: neurotrophin TRKC receptor binding
namespace: molecular_function
def: "Binding to a neurotrophin TRKC receptor." [GOC:ai]
synonym: "neurotrophin TRKC receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005171
name: hepatocyte growth factor receptor binding
namespace: molecular_function
def: "Binding to an hepatocyte growth factor receptor." [GOC:ai]
synonym: "hepatocyte growth factor" NARROW []
synonym: "hepatocyte growth factor receptor ligand" NARROW []
synonym: "HGF receptor binding" EXACT []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005172
name: vascular endothelial growth factor receptor binding
namespace: molecular_function
def: "Binding to a vascular endothelial growth factor receptor." [GOC:ai]
synonym: "vascular endothelial growth factor" NARROW []
synonym: "vascular endothelial growth factor receptor ligand" NARROW []
synonym: "VEGF receptor binding" EXACT []
synonym: "VEGFR binding" EXACT []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005173
name: stem cell factor receptor binding
namespace: molecular_function
def: "Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217]
synonym: "KIT binding" NARROW []
synonym: "SCF" NARROW []
synonym: "SCFR binding" EXACT []
synonym: "stem cell factor" NARROW []
synonym: "stem cell factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005174
name: CD40 receptor binding
namespace: molecular_function
def: "Binding to CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005175
name: CD27 receptor binding
namespace: molecular_function
def: "Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005176
name: ErbB-2 class receptor binding
namespace: molecular_function
def: "Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl]
synonym: "ErbB-2 class receptor ligand" NARROW []
synonym: "HER2 receptor binding" EXACT []
synonym: "HER2 receptor ligand" NARROW []
synonym: "Neu receptor binding" EXACT []
synonym: "Neu receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005177
name: obsolete neuroligin
namespace: molecular_function
def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai]
synonym: "neuroligin" EXACT []
is_obsolete: true
consider: GO:0042043

[Term]
id: GO:0005178
name: integrin binding
namespace: molecular_function
def: "Binding to an integrin." [GOC:ceb]
subset: goslim_chembl
synonym: "integrin ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding
is_a: GO:0044877 ! protein-containing complex binding
is_a: GO:0050839 ! cell adhesion molecule binding

[Term]
id: GO:0005179
name: hormone activity
namespace: molecular_function
def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.
subset: goslim_chembl
synonym: "cAMP generating peptide activity" NARROW []
synonym: "glycopeptide hormone" NARROW []
synonym: "lipopeptide hormone" NARROW []
synonym: "peptide hormone" NARROW []
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0005180
name: obsolete peptide hormone
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
synonym: "peptide hormone" EXACT []
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005181
name: obsolete glycopeptide hormone
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
synonym: "glycopeptide hormone" EXACT []
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005182
name: obsolete lipopeptide hormone
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
synonym: "lipopeptide hormone" EXACT []
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005183
name: gonadotropin hormone-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone]
synonym: "GnRH activity" EXACT [ISBN:0198506732]
synonym: "gonadotrophin hormone-releasing hormone activity" EXACT [GOC:dph]
synonym: "LH/FSH-RF" EXACT [ISBN:0198506732]
synonym: "LHRH activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0005184
name: neuropeptide hormone activity
namespace: molecular_function
def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
subset: goslim_chembl
synonym: "neurohormone" EXACT []
xref: Wikipedia:Neurohormone
is_a: GO:0005179 ! hormone activity
is_a: GO:0160041 ! neuropeptide activity

[Term]
id: GO:0005185
name: neurohypophyseal hormone activity
namespace: molecular_function
def: "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin." [GOC:mah, PMID:19243634]
synonym: "neurohypophysial hormone activity" EXACT [GOC:mah]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0005186
name: pheromone activity
namespace: molecular_function
def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732]
comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0005187
name: obsolete storage protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular location rather than a function.
synonym: "storage protein" EXACT []
is_obsolete: true
replaced_by: GO:0045735

[Term]
id: GO:0005188
name: obsolete larval serum protein (sensu Insecta)
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "arylphorin" NARROW []
synonym: "larval serum protein (sensu Insecta)" EXACT []
is_obsolete: true

[Term]
id: GO:0005189
name: obsolete milk protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "milk protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005190
name: obsolete seminal fluid protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "seminal fluid protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005191
name: obsolete acidic epididymal glycoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
synonym: "acidic epididymal glycoprotein" EXACT []
is_obsolete: true

[Term]
id: GO:0005192
name: obsolete urinary protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "urinary protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005193
name: obsolete major urinary protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "major urinary protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005194
name: obsolete cell adhesion molecule activity
namespace: molecular_function
def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732]
comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion.
synonym: "cell adhesion molecule activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515
consider: GO:0007155
consider: GO:0030246
consider: GO:0050839
consider: GO:0098631

[Term]
id: GO:0005198
name: structural molecule activity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005199
name: structural constituent of cell wall
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005200
name: structural constituent of cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
subset: goslim_drosophila
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005201
name: extracellular matrix structural constituent
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
comment: Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019
subset: goslim_drosophila
synonym: "core extracellular matrix" BROAD []
synonym: "core matrisome" BROAD []
synonym: "extracellular matrix glycoprotein" NARROW []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005202
name: obsolete collagen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "collagen" EXACT []
is_obsolete: true
consider: GO:0005581

[Term]
id: GO:0005203
name: obsolete proteoglycan
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005204
name: obsolete chondroitin sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "chondroitin sulfate proteoglycan" EXACT []
synonym: "chondroitin sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005205
name: obsolete chondroitin sulfate/dermatan sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "chondroitin sulfate/dermatan sulfate proteoglycan" EXACT []
synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005206
name: obsolete heparin sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "heparin sulfate proteoglycan" EXACT []
synonym: "heparin sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005207
name: obsolete extracellular matrix glycoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes localization and modification rather than activity.
synonym: "extracellular matrix glycoprotein" EXACT []
is_obsolete: true
consider: GO:0005201

[Term]
id: GO:0005208
name: obsolete amyloid protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "amyloid protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005209
name: obsolete plasma protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "plasma protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005211
name: obsolete plasma glycoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
synonym: "plasma glycoprotein" EXACT []
is_obsolete: true

[Term]
id: GO:0005212
name: structural constituent of eye lens
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005213
name: structural constituent of egg chorion
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
synonym: "structural constituent of chorion" BROAD []
synonym: "structural protein of chorion" NARROW []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005214
name: structural constituent of chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0042302 ! structural constituent of cuticle

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf]
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "carrier" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005216
name: monoatomic ion channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
synonym: "ion channel activity" BROAD []
is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0005217
name: intracellularly ligand-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "intracellular ligand-gated ion channel activity" BROAD []
synonym: "intracellular ligand-gated monoatomic ion channel activity" EXACT []
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0005219
name: ryanodine-sensitive calcium-release channel activity
namespace: molecular_function
def: "Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine." [GOC:dph, GOC:tb, PMID:22822064]
synonym: "caffeine-sensitive calcium-release channel" RELATED []
synonym: "ryanodine receptor" NARROW []
is_a: GO:0048763 ! calcium-induced calcium release activity

[Term]
id: GO:0005220
name: inositol 1,4,5-trisphosphate-gated calcium channel activity
namespace: molecular_function
alt_id: GO:0008095
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:28416699, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor]
synonym: "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity" EXACT []
synonym: "inositol-1,4,5-trisphosphate receptor activity" EXACT []
synonym: "InsP3 receptor" EXACT [GOC:bf]
synonym: "IP3 receptor activity" EXACT []
is_a: GO:0015278 ! intracellularly gated calcium channel activity

[Term]
id: GO:0005221
name: intracellularly cyclic nucleotide-activated monoatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
synonym: "intracellular cyclic nucleotide activated cation channel activity" BROAD []
synonym: "intracellular cyclic nucleotide activated monoatomic cation channel activity" EXACT []
synonym: "intracellular cyclic nucleotide-activated monoatomic cation channel activity" EXACT []
xref: Reactome:R-HSA-2514867 "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment"
is_a: GO:0005217 ! intracellularly ligand-gated monoatomic ion channel activity
is_a: GO:0043855 ! cyclic nucleotide-activated monoatomic ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0005222
name: intracellularly cAMP-activated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
synonym: "HCN channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "hyperpolarization-activated cyclic nucleotide-gated channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT []
synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT []
synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT []
synonym: "intracellular cAMP activated cation channel activity" EXACT []
synonym: "intracellular cAMP-activated cation channel activity" EXACT []
synonym: "intracellular cyclic AMP activated cation channel activity" EXACT []
is_a: GO:0005221 ! intracellularly cyclic nucleotide-activated monoatomic cation channel activity

[Term]
id: GO:0005223
name: intracellularly cGMP-activated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
synonym: "intracellular cGMP activated cation channel activity" EXACT []
synonym: "intracellular cGMP-activated cation channel activity" EXACT []
is_a: GO:0005221 ! intracellularly cyclic nucleotide-activated monoatomic cation channel activity

[Term]
id: GO:0005225
name: volume-sensitive anion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb]
synonym: "volume-regulated channel" BROAD []
xref: Reactome:R-HSA-8941543 "VRAC heteromer transports I-, Cl- from cytosol to extracellular region"
is_a: GO:0005253 ! monoatomic anion channel activity

[Term]
id: GO:0005227
name: calcium-activated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:mtg_transport]
synonym: "calcium activated cation channel activity" EXACT []
synonym: "intracellular calcium-activated potassium channel" NARROW []
synonym: "polycystin" NARROW []
xref: Reactome:R-HSA-9717383 "TRPM4 transports Na+ from the extracellular region to the cytosol"
is_a: GO:0022839 ! monoatomic ion-gated channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0005228
name: intracellular sodium-activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167]
synonym: "intracellular sodium activated potassium channel activity" EXACT []
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022839 ! monoatomic ion-gated channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0005229
name: intracellularly calcium-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, PMID:29236691]
synonym: "intracellular calcium activated chloride channel activity" EXACT []
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity
is_a: GO:0141147 ! intracellularly calcium-gated channel activity

[Term]
id: GO:0005230
name: extracellular ligand-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "extracellular ligand-gated ion channel activity" BROAD []
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0005231
name: excitatory extracellular ligand-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]
xref: Reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors"
xref: Reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors"
xref: Reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors"
xref: Reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell"
xref: Reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors"
is_a: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity

[Term]
id: GO:0005234
name: extracellularly glutamate-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
synonym: "extracellular-glutamate-gated ion channel activity" EXACT []
is_a: GO:0005231 ! excitatory extracellular ligand-gated monoatomic ion channel activity

[Term]
id: GO:0005237
name: inhibitory extracellular ligand-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels." [GOC:mah, ISBN:0323037070]
synonym: "inhibitory extracellular ligand-gated ion channel activity" BROAD []
is_a: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity

[Term]
id: GO:0005240
name: obsolete glycine receptor-associated protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not describe a molecular function.
synonym: "glycine receptor-associated protein" EXACT []
is_obsolete: true
consider: GO:0005515

[Term]
id: GO:0005241
name: obsolete inward rectifier channel
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "inward rectifier channel" EXACT []
is_obsolete: true
consider: GO:0005242

[Term]
id: GO:0005242
name: inward rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]
synonym: "Kir channel activity" EXACT [GOC:cb]
xref: Reactome:R-HSA-1296045 "Activation of Potassium transport channels"
xref: Reactome:R-HSA-1296046 "KCNJs transport K+ from the extracellular region to cytosol"
xref: Reactome:R-HSA-1369017 "Activation of ATP sensitive Potassium channels in muscle cells"
xref: Reactome:R-HSA-5678261 "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5678418 "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9729870 "KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol"
xref: Reactome:R-HSA-9730521 "SARS-CoV-2 3a induces potassium efflux"
xref: Reactome:R-HSA-9731072 "SARS-CoV-1 3a tetramer induces potassium efflux"
is_a: GO:0005249 ! voltage-gated potassium channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0005243
name: gap junction channel activity
namespace: molecular_function
alt_id: GO:0015285
alt_id: GO:0015286
def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]
synonym: "connexin" RELATED []
synonym: "innexin" NARROW []
synonym: "innexin channel activity" EXACT []
synonym: "intercellular channel" BROAD []
xref: Reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane"
xref: Reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication"
xref: Reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication"
xref: Reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication"
xref: Reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"
is_a: GO:0022829 ! wide pore channel activity

[Term]
id: GO:0005244
name: voltage-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "voltage gated ion channel activity" EXACT []
synonym: "voltage-dependent ion channel activity" EXACT []
synonym: "voltage-gated ion channel activity" BROAD []
is_a: GO:0005216 ! monoatomic ion channel activity
is_a: GO:0022832 ! voltage-gated channel activity

[Term]
id: GO:0005245
name: voltage-gated calcium channel activity
namespace: molecular_function
alt_id: GO:0010173
alt_id: GO:0015270
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
synonym: "depolarization-activated calcium channel" BROAD []
synonym: "depolarization-activated voltage gated calcium channel activity" EXACT []
synonym: "depolarization-activated voltage-gated calcium channel" EXACT []
synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT []
synonym: "dihydropyridine-sensitive calcium channel activity" NARROW []
synonym: "voltage gated calcium channel activity" EXACT []
synonym: "voltage-dependent calcium channel activity" EXACT []
synonym: "voltage-gated calcium ion channel activity" EXACT []
synonym: "voltage-sensitive calcium channel" EXACT []
xref: Reactome:R-HSA-265645 "Calcium Influx through Voltage-gated Calcium Channels"
xref: Reactome:R-HSA-5577213 "LTCC multimer transports Ca2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9701055 "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9701141 "TRPV1 transports Ca2+ from extracellular region to cytosol"
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0022843 ! voltage-gated monoatomic cation channel activity

[Term]
id: GO:0005246
name: calcium channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a calcium channel." [GOC:mah]
is_a: GO:0099106 ! ion channel regulator activity

[Term]
id: GO:0005247
name: voltage-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
synonym: "voltage gated chloride channel activity" EXACT []
synonym: "voltage-dependent chloride channel activity" EXACT []
xref: Reactome:R-HSA-2744228 "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region"
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0008308 ! voltage-gated monoatomic anion channel activity

[Term]
id: GO:0005248
name: voltage-gated sodium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
synonym: "voltage gated sodium channel activity" EXACT []
synonym: "voltage-dependent sodium channel activity" EXACT []
synonym: "voltage-gated sodium ion channel activity" EXACT []
synonym: "voltage-sensitive sodium channel" EXACT []
xref: Reactome:R-HSA-5576895 "SCNAs:SNCBs transport Na+ from extracellular region to cytosol"
is_a: GO:0005272 ! sodium channel activity

[Term]
id: GO:0005249
name: voltage-gated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
synonym: "voltage gated potassium channel activity" EXACT []
synonym: "voltage-dependent potassium channel activity" EXACT []
synonym: "voltage-gated potassium ion channel activity" EXACT []
synonym: "voltage-sensitive potassium channel" EXACT []
xref: Reactome:R-HSA-1296127 "Activation of voltage gated Potassium channels"
xref: Reactome:R-HSA-9659554 "KCNQ4 transports K+ from the cytosol to the extracellular region"
xref: Reactome:R-HSA-9667761 "KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region"
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022843 ! voltage-gated monoatomic cation channel activity

[Term]
id: GO:0005250
name: A-type (transient outward) potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340]
xref: Reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region"
is_a: GO:0015271 ! outward rectifier potassium channel activity

[Term]
id: GO:0005251
name: delayed rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]
xref: Reactome:R-HSA-5577050 "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region"
xref: Reactome:R-HSA-5577237 "KCNH2:KCNE transport K+ from cytosol to extracellular region"
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0005252
name: open rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0005253
name: monoatomic anion channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel." [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
synonym: "anion channel activity" BROAD []
synonym: "non-selective anion channel activity" NARROW []
xref: Reactome:R-HSA-432034 "Aquaporin-6 passively transports anions into vesicles"
xref: Reactome:R-HSA-432036 "Aquaporin-6 passively transports anions out of vesicles"
xref: Reactome:R-HSA-9855161 "Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region"
is_a: GO:0005216 ! monoatomic ion channel activity
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity

[Term]
id: GO:0005254
name: chloride channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
xref: Reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-427570 "Group 3 - Selective Cl- transport"
xref: Reactome:R-HSA-9659568 "ANO1 transports cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-9712204 "ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region"
xref: Reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol"
xref: Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol"
is_a: GO:0005253 ! monoatomic anion channel activity
is_a: GO:0015108 ! chloride transmembrane transporter activity

[Term]
id: GO:0005260
name: intracellularly ATP-gated chloride channel activity
namespace: molecular_function
alt_id: GO:0005224
def: "Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [PMID:24727426, PMID:9922375]
comment: This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
synonym: "CFTR" EXACT []
synonym: "channel-conductance-controlling ATPase activity" RELATED [EC:5.6.1.6]
synonym: "cystic fibrosis transmembrane conductance regulator" NARROW []
xref: EC:5.6.1.6
xref: MetaCyc:3.6.3.49-RXN
xref: TC:3.A.1.202.1
xref: Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity
is_a: GO:0099142 ! intracellularly ATP-gated ion channel activity

[Term]
id: GO:0005261
name: monoatomic cation channel activity
namespace: molecular_function
alt_id: GO:0015281
alt_id: GO:0015338
def: "Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
synonym: "cation channel activity" BROAD []
synonym: "cation diffusion facilitator activity" EXACT []
synonym: "non-selective cation channel activity" NARROW []
xref: Reactome:R-HSA-1168376 "STIM1 oligomerizes"
xref: Reactome:R-HSA-1296043 "Activation of HCN channels"
xref: Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol"
xref: Reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol"
xref: Reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7"
xref: Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT"
xref: Reactome:R-HSA-9706720 "SARS-CoV-1 E transports Ca2+"
xref: Reactome:R-HSA-9712190 "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol"
xref: Reactome:R-HSA-9754616 "SARS-CoV-2 E pentamer transports Ca2+"
xref: Reactome:R-HSA-9837835 "SH pentamer transports K+"
is_a: GO:0005216 ! monoatomic ion channel activity
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity

[Term]
id: GO:0005262
name: calcium channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
xref: Reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol"
xref: Reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma"
xref: Reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels"
xref: Reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol"
xref: Reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space"
xref: Reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix"
xref: Reactome:R-HSA-9663785 "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol"
xref: Reactome:R-HSA-9858800 "TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol"
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0015085 ! calcium ion transmembrane transporter activity

[Term]
id: GO:0005267
name: potassium channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
xref: Reactome:R-HSA-1296024 "Activation of ATP sensitive Potassium channels in neuroendocrine cells"
xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with  Intermediate conductance"
xref: Reactome:R-HSA-1296037 "Activation of Ca2+ activated Potassium channels with large conductance"
xref: Reactome:R-HSA-1296039 "Activation of Ca2+ activated Potassium channels with small conductance"
xref: Reactome:R-HSA-1296348 "Activation of TWIK-related K+ channel (TREK)"
xref: Reactome:R-HSA-1299297 "Activation of THIK"
xref: Reactome:R-HSA-1299304 "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels"
xref: Reactome:R-HSA-1299318 "Activation of TASK"
xref: Reactome:R-HSA-1299338 "Activation of TRESK"
xref: Reactome:R-HSA-1299359 "Activation of TALK"
xref: Reactome:R-HSA-2534365 "Slo3 Potassium Transport"
xref: Reactome:R-HSA-5578910 "KCNK dimers transport K+ from cytosol to extracellular region"
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0015079 ! potassium ion transmembrane transporter activity

[Term]
id: GO:0005272
name: sodium channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol"
xref: Reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol"
xref: Reactome:R-HSA-9717374 "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol"
xref: Reactome:R-HSA-9717382 "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol"
xref: Reactome:R-HSA-9717395 "TRPM5 transports Na+ from the extracellular region to the cytosol"
xref: Reactome:R-HSA-9717396 "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol"
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity

[Term]
id: GO:0005274
name: allantoin:proton symporter activity
namespace: molecular_function
alt_id: GO:0015206
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1]
synonym: "allantoin permease activity" RELATED []
synonym: "allantoin uptake transmembrane transporter activity" NARROW []
synonym: "allantoin/allantoate transporter" BROAD []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0005275
name: amine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005279
def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "amine/amide/polyamine channel activity" BROAD []
synonym: "amine/polyamine transmembrane transporter activity" EXACT []
synonym: "amino acid-polyamine transmembrane transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0005276
name: obsolete vesicular amino acid:proton antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in)." [GOC:mah]
comment: The reason for obsoletion is that the cellular component does not belong is the MF according to the documentation: http://wiki.geneontology.org/index.php/Transporter_terms_standard_definitions
synonym: "hydrogen:vesicular amine antiporter activity" EXACT []
synonym: "vesicular hydrogen:amino acid antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0005277
name: acetylcholine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles"
is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:1901375 ! acetate ester transmembrane transporter activity

[Term]
id: GO:0005278
name: acetylcholine:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13]
synonym: "acetylcholine:hydrogen antiporter activity" EXACT []
is_a: GO:0005277 ! acetylcholine transmembrane transporter activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0005280
name: amino acid:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai]
synonym: "cation/amino acid symporter" BROAD []
synonym: "hydrogen:amino acid symporter activity" EXACT []
xref: Reactome:R-HSA-8875623 "SLC25A18,22 import L-Glu, H+"
is_a: GO:0005416 ! amino acid:monoatomic cation symporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0005281
name: obsolete general amino acid permease activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "general amino acid permease activity" EXACT []
synonym: "general amino acid transporter" BROAD []
is_obsolete: true
replaced_by: GO:0015171

[Term]
id: GO:0005283
name: amino acid:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005284
alt_id: GO:0005285
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "insulin-activated sodium/amino acid transporter activity" NARROW []
synonym: "insulin-activated sodium:amino acid symporter activity" NARROW []
synonym: "insulin-activated sodium:amino acid transporter activity" NARROW []
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "sodium/amino acid transporter activity" BROAD []
synonym: "sodium/excitatory amino acid cotransporter activity" BROAD []
synonym: "sodium/excitatory amino acid symporter activity" EXACT []
synonym: "sodium:amino acid symporter activity" EXACT []
synonym: "sodium:amino acid transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" NARROW []
is_a: GO:0005416 ! amino acid:monoatomic cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005287
name: high-affinity basic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity basic amino acid transmembrane transporter activity" EXACT []
synonym: "high-affinity basic amino acid transporter activity" BROAD []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity

[Term]
id: GO:0005289
name: high-affinity L-arginine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity arginine transmembrane transporter activity" EXACT []
synonym: "high-affinity arginine transmembrane transporter activity" EXACT []
synonym: "high-affinity arginine transporter activity" BROAD []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0061459 ! L-arginine transmembrane transporter activity

[Term]
id: GO:0005290
name: L-histidine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-histidine transporter activity" BROAD []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:0005291
name: high-affinity L-histidine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity histidine permease activity" RELATED []
synonym: "high affinity L-histidine transmembrane transporter activity" EXACT []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0005290 ! L-histidine transmembrane transporter activity

[Term]
id: GO:0005292
name: high-affinity lysine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity lysine transmembrane transporter activity" EXACT []
synonym: "high affinity lysine transporter activity" BROAD []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0015189 ! L-lysine transmembrane transporter activity

[Term]
id: GO:0005294
name: neutral L-amino acid secondary active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
synonym: "neutral L-amino acid porter activity" RELATED []
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005295
name: neutral L-amino acid:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005282
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in)." [TC:2.A.23.3.1]
synonym: "neutral amino acid-sodium cotransporter" BROAD []
synonym: "neutral amino acid:sodium symporter activity" EXACT []
synonym: "sodium/neutral amino acid transporter" BROAD []
is_a: GO:0005283 ! amino acid:sodium symporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity

[Term]
id: GO:0005297
name: proline:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai]
synonym: "hydrogen/proline transporter" BROAD []
is_a: GO:0005280 ! amino acid:proton symporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0005298
name: proline:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1]
synonym: "sodium/proline symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-118
xref: Reactome:R-HSA-444100 "PROT mediates L-proline uptake"
xref: RHEA:28967
is_a: GO:0005283 ! amino acid:sodium symporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0005300
name: high-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729]
synonym: "high-affinity tryptophan transporter activity" BROAD []
is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity

[Term]
id: GO:0005301
name: obsolete valine/tyrosine/tryptophan permease activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT []
synonym: "valine/tyrosine/tryptophan permease activity" EXACT []
is_obsolete: true
consider: GO:0005302
consider: GO:0005304
consider: GO:0015196
consider: GO:0022857

[Term]
id: GO:0005302
name: L-tyrosine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015508
def: "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-tyrosine permease activity" EXACT []
synonym: "L-tyrosine transporter activity" BROAD []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0005304
name: L-valine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "L-valine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
synonym: "valine/tyrosine/tryptophan permease activity" NARROW []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity

[Term]
id: GO:0005307
name: choline:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5]
synonym: "sodium/choline symporter activity" EXACT []
xref: RHEA:76443
is_a: GO:0015220 ! choline transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005308
name: creatine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0005309
name: creatine:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4]
synonym: "sodium/chloride-dependent creatine transporter" BROAD []
xref: Reactome:R-HSA-200396 "Creatine transport across the plasma membrane"
is_a: GO:0005308 ! creatine transmembrane transporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity

[Term]
id: GO:0005310
name: dicarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005312
alt_id: GO:0015365
def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
synonym: "dicarboxylate carrier" NARROW []
synonym: "dicarboxylic acid permease activity" RELATED []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate"
xref: Reactome:R-HSA-372843 "SLC25A10 mediates exchange of malate and phosphate"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0005311
name: obsolete sodium:dicarboxylate/tricarboxylate symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" EXACT []
is_obsolete: true
consider: GO:0005310
consider: GO:0005343
consider: GO:0015142

[Term]
id: GO:0005313
name: L-glutamate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "glutamate transmembrane transporter activity" BROAD []
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-glutamate transporter activity" BROAD []
xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle"
xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+"
xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+"
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0005314
name: high-affinity L-glutamate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5]
synonym: "high-affinity glutamate transmembrane transporter activity" BROAD []
synonym: "high-affinity glutamate transporter activity" BROAD []
xref: Reactome:R-HSA-210404 "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+"
xref: Reactome:R-HSA-428015 "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5625015 "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5625029 "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol"
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015501 ! glutamate:sodium symporter activity

[Term]
id: GO:0005315
name: phosphate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005317
alt_id: GO:1901677
def: "Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
synonym: "inorganic phosphate transmembrane transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005316
name: high-affinity phosphate:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction:phosphate(out) + Na+(out) = phosphate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.20.2.2]
synonym: "high affinity inorganic phosphate:sodium symporter activity" EXACT []
synonym: "high-affinity inorganic phosphate:sodium symporter activity" EXACT []
synonym: "sodium/phosphate cotransporter activity" BROAD []
is_a: GO:0005436 ! sodium:phosphate symporter activity

[Term]
id: GO:0005318
name: obsolete phosphate:hydrogen symporter
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
synonym: "phosphate:hydrogen symporter" EXACT []
synonym: "phosphate:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015317

[Term]
id: GO:0005319
name: lipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
synonym: "apolipoprotein" RELATED []
synonym: "lipophorin" NARROW []
xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux"
xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx"
xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region"
xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region"
xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane"
xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL"
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0005320
name: obsolete apolipoprotein
namespace: molecular_function
alt_id: GO:0015907
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "apolipoprotein" EXACT []
is_obsolete: true
consider: GO:0005319

[Term]
id: GO:0005321
name: obsolete high-density lipoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "HDL" EXACT []
synonym: "high-density lipoprotein" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005322
name: obsolete low-density lipoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "LDL" EXACT []
synonym: "low-density lipoprotein" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005323
name: obsolete very-low-density lipoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "very-low-density lipoprotein" EXACT []
synonym: "VLDL" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005324
name: long-chain fatty acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005325
alt_id: GO:0008562
def: "Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acid transporter activity" RELATED []
xref: Reactome:R-HSA-2046087 "Translocation of tetracosahexaenoyl-CoA to peroxisomes"
xref: Reactome:R-HSA-2046093 "Translocation of tetracosapentaenoyl-CoA to peroxisomes"
xref: Reactome:R-HSA-382575 "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix"
xref: Reactome:R-HSA-434381 "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol"
xref: Reactome:R-HSA-5684043 "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix"
xref: RHEA:39283
is_a: GO:0015245 ! fatty acid transmembrane transporter activity

[Term]
id: GO:0005326
name: neurotransmitter transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
synonym: "neurotransmitter transporter activity" RELATED []
xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline"
xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0005328
name: neurotransmitter:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
synonym: "sodium/neurotransmitter symporter activity" EXACT []
is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005330
name: dopamine:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005329
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.3]
synonym: "dopamine transmembrane transporter activity" EXACT []
synonym: "dopamine:sodium:chloride symporter activity" EXACT []
synonym: "sodium/dopamine symporter activity" EXACT []
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0005332
name: gamma-aminobutyric acid:sodium:chloride symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in)." [PMID:7589472, PMID:7861179]
comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'.
synonym: "4-aminobutanoate:sodium symporter activity" EXACT []
synonym: "4-aminobutyrate:sodium symporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" EXACT []
synonym: "GABA:sodium symporter activity" EXACT []
synonym: "gamma-aminobutyric acid:sodium symporter activity" EXACT []
synonym: "sodium/chloride-dependent GABA transporter activity" BROAD []
xref: Reactome:R-HSA-444007 "GAT1-3 mediate Na+/Cl- dependent GABA transport"
xref: TC:2.A.22.3.2
is_a: GO:0005283 ! amino acid:sodium symporter activity
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity
is_a: GO:0140161 ! monocarboxylate:sodium symporter activity

[Term]
id: GO:0005334
name: norepinephrine:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005333
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.2]
synonym: "levarterenol transporter activity" EXACT []
synonym: "noradrenaline transporter activity" EXACT []
synonym: "norepinephrine transmembrane transporter activity" EXACT []
synonym: "norepinephrine:sodium:chloride symporter activity" EXACT []
synonym: "sodium/norepinephrine symporter activity" EXACT []
xref: Reactome:R-HSA-443997 "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5659764 "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol"
xref: Wikipedia:Norepinephrine_transporter
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0005335
name: serotonin:sodium:chloride symporter activity
namespace: molecular_function
alt_id: GO:0005336
alt_id: GO:0015222
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)." [PMID:21752877, PMID:22519513]
synonym: "serotonin transmembrane transporter activity" EXACT []
synonym: "serotonin:sodium symporter activity" RELATED []
synonym: "sodium/serotonin symporter activity" EXACT []
xref: Reactome:R-HSA-444008 "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol"
xref: RHEA:51196
xref: TC:2.A.22.1.1
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0005337
name: nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]
synonym: "intracellular nucleoside transmembrane transporter activity" NARROW []
xref: Reactome:R-HSA-109527 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2"
xref: Reactome:R-HSA-109529 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2"
xref: Reactome:R-HSA-109534 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1"
xref: Reactome:R-HSA-109536 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1"
xref: Reactome:R-HSA-5628807 "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-727740 "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4"
xref: Reactome:R-HSA-727749 "SLC29A3 transports nucleosides from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-727767 "SLC29A3 transports nucleosides from cytosol to lysosomal lumen"
xref: Reactome:R-HSA-727768 "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4"
xref: Reactome:R-HSA-9751024 "SLC29A1,2 transport 6MP from extracellular region to cytosol"
xref: Reactome:R-HSA-9754929 "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix"
xref: Reactome:R-HSA-9755015 "SLC29A1 transports RBV from extracellular region to cytosol"
xref: Reactome:R-HSA-9755035 "SLC29A1 transports RBV from cytosol to extracellular region"
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0005338
name: nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005339
def: "Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]
xref: Reactome:R-HSA-744230 "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP"
xref: Reactome:R-HSA-744231 "SLC35D2 exchanges UDP-GlcNAc for UMP"
xref: Reactome:R-HSA-9792608 "SLC35D2 exchanges UDP-D-glucose for UMP"
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0005340
name: nucleotide-sulfate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005341
def: "Enables the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport]
synonym: "nucleotide-sulphate transporter activity" EXACT []
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity

[Term]
id: GO:0005342
name: organic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0005343
name: organic acid:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1]
synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:R-HSA-8876312 "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol"
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005344
name: oxygen carrier activity
namespace: molecular_function
alt_id: GO:0015033
def: "Binding to oxygen and delivering it to an acceptor molecule or a specific location." [GOC:ai]
synonym: "globin" NARROW []
synonym: "hemerythrin" NARROW []
synonym: "hemocyanin" NARROW []
synonym: "oxygen-carrying" NARROW []
is_a: GO:0140104 ! molecular carrier activity

[Term]
id: GO:0005345
name: purine nucleobase transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732]
synonym: "purine base transmembrane transporter activity" EXACT [GOC:go_curators]
synonym: "purine transmembrane transporter activity" RELATED []
is_a: GO:0015205 ! nucleobase transmembrane transporter activity

[Term]
id: GO:0005346
name: purine ribonucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0005347
name: ATP transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005348
def: "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai]
xref: Reactome:R-HSA-9717392 "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region"
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0005350
name: pyrimidine nucleobase transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [GOC:ai]
synonym: "pyrimidine base transmembrane transporter activity" EXACT [GOC:go_curators]
synonym: "pyrimidine transmembrane transporter activity" RELATED []
is_a: GO:0015205 ! nucleobase transmembrane transporter activity

[Term]
id: GO:0005351
name: carbohydrate:proton symporter activity
namespace: molecular_function
alt_id: GO:0005403
alt_id: GO:0015542
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in)." [TC:2.A.1.1]
synonym: "cation/sugar symporter activity" NARROW []
synonym: "hydrogen:sugar symporter activity" NARROW []
synonym: "hydrogen:sugar transporter activity" BROAD []
synonym: "lactose/glucose efflux transporter activity" NARROW []
synonym: "proton:sugar symporter activity" EXACT []
synonym: "sugar efflux transmembrane transporter activity" NARROW [PMID:20971900]
synonym: "sugar porter activity" NARROW []
synonym: "sugar transporter" BROAD []
synonym: "sugar:hydrogen ion symporter activity" NARROW []
synonym: "sugar:hydrogen symporter activity" EXACT []
synonym: "sugar:proton symporter activity" NARROW []
xref: TC:2.A.1.1
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0005352
name: alpha-glucoside:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11]
synonym: "alpha-glucoside:hydrogen symporter activity" EXACT []
synonym: "general alpha-glucoside transporter activity" BROAD []
synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT []
synonym: "general alpha-glucoside:proton symporter activity" EXACT []
is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0005353
name: fructose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015585
alt_id: GO:0019192
def: "Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "fructose permease activity" EXACT []
synonym: "fructose porter activity" EXACT []
xref: Reactome:R-HSA-189222 "SLC2A5 transports fructose from extracellular region to cytosol"
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0005354
name: galactose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0005355
name: obsolete glucose transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
comment: This term was obsoleted because it represents the same reaction as D-glucose transmembrane transporter activity ; GO:0055056.
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
synonym: "glucose permease activity" EXACT []
synonym: "glucose transmembrane transporter activity" EXACT []
synonym: "lactose/glucose efflux transporter activity" NARROW []
xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2"
xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen"
is_obsolete: true
replaced_by: GO:0055056

[Term]
id: GO:0005356
name: D-glucose:proton symporter activity
namespace: molecular_function
alt_id: GO:0005361
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "glucose:proton symporter activity" EXACT []
synonym: "hydrogen:glucose symporter activity" EXACT []
synonym: "hydrogen:glucose transporter activity" RELATED []
synonym: "transepithelial hydrogen/glucose transporter activity" RELATED []
synonym: "transepithelial hydrogen:glucose symporter activity" NARROW []
synonym: "transepithelial hydrogen:glucose transporter activity" RELATED []
is_a: GO:0009679 ! hexose:proton symporter activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0005357
name: obsolete constitutive glucose:proton symporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
comment: The reason for obsoletion is that the constitutive aspect of the transporter is unlikely to be an aspect of the activity, but instead it probably relates to the expression level of the transporter.
synonym: "constitutive hydrogen/glucose transporter activity" BROAD []
synonym: "constitutive hydrogen:glucose symporter activity" EXACT []
synonym: "constitutive hydrogen:glucose transporter activity" BROAD []
is_obsolete: true

[Term]
id: GO:0005358
name: high-affinity D-glucose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high-affinity glucose:proton symporter activity" EXACT []
synonym: "high-affinity hydrogen/glucose transporter activity" BROAD []
synonym: "high-affinity hydrogen:glucose symporter activity" EXACT []
synonym: "high-affinity hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! D-glucose:proton symporter activity

[Term]
id: GO:0005359
name: low-affinity D-glucose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "low-affinity glucose:proton symporter activity" EXACT []
synonym: "low-affinity hydrogen/glucose transporter activity" BROAD []
synonym: "low-affinity hydrogen:glucose symporter activity" EXACT []
synonym: "low-affinity hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! D-glucose:proton symporter activity

[Term]
id: GO:0005360
name: insulin-responsive D-glucose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "insulin-responsive glucose:proton symporter activity" EXACT []
synonym: "insulin-responsive hydrogen:glucose symporter activity" EXACT []
synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED []
synonym: "transepithelial hydrogen/glucose transporter activity" RELATED []
is_a: GO:0005356 ! D-glucose:proton symporter activity

[Term]
id: GO:0005362
name: low-affinity D-glucose:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-]
synonym: "low-affinity glucose-sodium cotransporter activity" BROAD []
synonym: "low-affinity glucose:sodium symporter activity" EXACT []
xref: Reactome:R-HSA-429567 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4"
is_a: GO:0005412 ! D-glucose:sodium symporter activity

[Term]
id: GO:0005363
name: maltose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015581
def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "maltose porter activity" EXACT []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0005364
name: maltose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10]
synonym: "hydrogen/maltose transporter activity" BROAD []
synonym: "maltose permease" BROAD []
synonym: "maltose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0005363 ! maltose transmembrane transporter activity

[Term]
id: GO:0005365
name: myo-inositol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]
synonym: "vitamin Bh transporter activity" EXACT []
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0005366
name: myo-inositol:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8]
synonym: "hydrogen/myo-inositol transporter activity" BROAD []
synonym: "myo-inositol:hydrogen symporter activity" EXACT []
xref: Reactome:R-HSA-429101 "HMIT co-transports myo-inositol with a proton"
xref: RHEA:60364
is_a: GO:0005365 ! myo-inositol transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0005367
name: myo-inositol:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-]
synonym: "myo-inositol-sodium cotransporter activity" BROAD []
xref: Reactome:R-HSA-429663 "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol"
is_a: GO:0005365 ! myo-inositol transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005368
name: taurine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai]
subset: gocheck_do_not_annotate
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0005369
name: taurine:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3]
synonym: "sodium/chloride-dependent taurine transporter" BROAD []
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0005368 ! taurine transmembrane transporter activity

[Term]
id: GO:0005371
name: tricarboxylate secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005370
def: "Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0815340729]
synonym: "tricarboxylate carrier activity" EXACT []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0005372
name: water transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of water (H2O) from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity

[Term]
id: GO:0005373
name: obsolete heavy metal ion porter activity
namespace: molecular_function
def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "heavy metal ion porter activity" EXACT []
synonym: "metal ion transporter" BROAD []
is_obsolete: true
consider: GO:0015291
consider: GO:0046873

[Term]
id: GO:0005375
name: copper ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005378
alt_id: GO:0005379
alt_id: GO:0005380
alt_id: GO:0015088
def: "Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]
synonym: "copper uptake transmembrane transporter activity" RELATED []
synonym: "intracellular copper ion transporter" NARROW []
synonym: "plasma membrane copper transporter" NARROW []
xref: Reactome:R-HSA-437300 "SLC31A1 transports Cu2+ from extracellular region to cytosol"
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005376
name: obsolete plasma membrane copper transporter
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "plasma membrane copper transporter" EXACT []
is_obsolete: true
consider: GO:0005375
consider: GO:0005886

[Term]
id: GO:0005377
name: obsolete intracellular copper ion transporter
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "intracellular copper ion transporter" EXACT []
synonym: "intracellular copper transporter" EXACT []
is_obsolete: true
consider: GO:0005375
consider: GO:0005622

[Term]
id: GO:0005381
name: iron ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005382
alt_id: GO:0016033
alt_id: GO:0097689
def: "Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]
comment: An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell.
synonym: "iron cation channel activity" EXACT []
synonym: "iron channel activity" EXACT []
synonym: "iron transporter activity" EXACT []
synonym: "multicopper ferroxidase iron transport mediator activity" RELATED []
synonym: "transmembrane iron ion permease activity" EXACT []
synonym: "transmembrane iron permease activity" EXACT []
synonym: "zinc, iron permease activity" RELATED []
xref: Reactome:R-HSA-435349 "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5623558 "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5655733 "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region"
xref: Reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region"
xref: Reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol"
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005384
name: manganese ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]
xref: MetaCyc:RXN0-16
xref: Reactome:R-HSA-8959798 "SLC30A10 transports Mn2+ from cytosol to extracellular region"
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005385
name: zinc ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]
synonym: "cobalt, zinc uptake permease activity" RELATED []
synonym: "zinc, cadmium uptake permease activity" RELATED []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
synonym: "zinc, iron permease activity" NARROW []
xref: MetaCyc:RXN0-12
xref: Reactome:R-HSA-435366 "ZnT1 mediates the efflux of zinc from the cell"
xref: Reactome:R-HSA-435375 "ZnT2 facilitates zinc vesicular sequestration"
xref: Reactome:R-HSA-437084 "ZnT3 transports zinc into synaptic vesicles"
xref: Reactome:R-HSA-437085 "ZnT5 transports zinc into secretory granules in pancreatic beta cells"
xref: Reactome:R-HSA-437136 "SLC30A8 transports Zn2+ from cytosol to secretory granule"
xref: Reactome:R-HSA-437139 "ZnT8 transports zinc into the Golgi apparatus"
xref: Reactome:R-HSA-442317 "ZIP6 and ZIP14 mediate zinc influx into cells"
xref: Reactome:R-HSA-442345 "hZIP10 mediates zinc influx into cells"
xref: Reactome:R-HSA-442387 "ZIP8 mediates zinc influx into cells"
xref: Reactome:R-HSA-442393 "ZIP7 mediates zinc efflux from the endoplasmic reticulum"
xref: Reactome:R-HSA-442405 "hZIP5 mediates zinc uptake by cells"
xref: Reactome:R-HSA-442422 "SLC39A1-4 transports Zn2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5654125 "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9820566 "ZnT5 transports zinc into the golgi apparatus"
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005388
name: P-type calcium transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)." [RHEA:18105]
synonym: "ATP-dependent calcium transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled calcium transmembrane transporter activity" RELATED []
synonym: "Ca(2+)-transporting ATPase activity" RELATED [EC:7.2.2.10]
synonym: "Ca2+-transporting ATPase activity" RELATED [EC:7.2.2.10]
synonym: "calcium efflux ATPase" NARROW []
synonym: "calcium pump" BROAD []
synonym: "calcium transmembrane transporter activity, phosphorylative mechanism" EXACT []
synonym: "calcium transporting ATPase activity" EXACT []
synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:7.2.2.10]
synonym: "calcium-transporting ATPase activity" EXACT []
synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW []
xref: EC:7.2.2.10
xref: MetaCyc:TRANS-RXN-194
xref: Reactome:R-HSA-418309 "ATP2B1-4 transport cytosolic Ca2+ to extracellular region"
xref: Reactome:R-HSA-418365 "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen"
xref: Reactome:R-HSA-427910 "ATP2A1-3 transport Ca2+ from cytosol to ER lumen"
xref: Reactome:R-HSA-936883 "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen"
xref: Reactome:R-HSA-9662114 "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region"
xref: Reactome:R-HSA-9664214 "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region"
xref: RHEA:18105
is_a: GO:0015085 ! calcium ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0005391
name: P-type sodium:potassium-exchanging transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:7.2.2.13]
synonym: "Na(+)/K(+)-ATPase activity" RELATED [EC:7.2.2.13]
synonym: "Na(+)/K(+)-exchanging ATPase activity" RELATED [EC:7.2.2.13]
synonym: "Na+,K+-ATPase activity" RELATED [EC:7.2.2.13]
synonym: "Na+/K+-ATPase activity" RELATED [EC:7.2.2.13]
synonym: "Na+/K+-exchanging ATPase activity" RELATED [EC:7.2.2.13]
synonym: "Na,K-activated ATPase activity" RELATED [EC:7.2.2.13]
synonym: "P-type sodium:potassium-exchanging ATPase activity" EXACT []
synonym: "sodium pump" BROAD [EC:7.2.2.13]
synonym: "sodium/potassium-exchanging ATPase activity" EXACT []
synonym: "sodium/potassium-transporting ATPase activity" EXACT []
synonym: "sodium:potassium exchanging ATPase activity" EXACT []
synonym: "sodium:potassium-exchanging ATPase activity" EXACT []
xref: EC:7.2.2.13
xref: MetaCyc:3.6.3.9-RXN
xref: Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+"
xref: RHEA:18353
xref: TC:3.A.3.1.1
xref: Wikipedia:ATPase\,_Na%2B/K%2B_transporting\,_alpha_1
is_a: GO:0008554 ! P-type sodium transporter activity
is_a: GO:0008556 ! P-type potassium transmembrane transporter activity

[Term]
id: GO:0005395
name: obsolete eye pigment precursor transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1]
comment: This term has been obsoleted because eye pigment precursors are nucleotides and amino acids, and there are terms to annotate these functions.
is_obsolete: true

[Term]
id: GO:0005396
name: obsolete transmembrane conductance regulator activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong.
synonym: "transmembrane conductance regulator activity" EXACT []
is_obsolete: true
consider: GO:0043267

[Term]
id: GO:0005400
name: obsolete peroxisomal membrane transporter
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "peroxisomal membrane transporter" EXACT []
is_obsolete: true
consider: GO:0005215
consider: GO:0005777

[Term]
id: GO:0005402
name: carbohydrate:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai]
synonym: "carbohydrate:cation symporter activity" BROAD []
synonym: "cation/sugar symporter activity" EXACT []
synonym: "cation:sugar symporter activity" EXACT []
synonym: "sugar:cation symporter activity" NARROW []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity

[Term]
id: GO:0005412
name: D-glucose:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in)." [TC:2.A.21.3.-]
synonym: "glucose:sodium symporter activity" EXACT []
synonym: "sodium/glucose symporter activity" EXACT []
xref: MetaCyc:RXN-22596
xref: Reactome:R-HSA-189208 "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol"
xref: Reactome:R-HSA-429613 "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5656356 "Defective SLC5A1 does not cotransport Glc and Na+"
xref: Reactome:R-HSA-5658163 "Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-8932955 "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol"
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0005415
name: nucleoside:sodium symporter activity
namespace: molecular_function
alt_id: GO:0008522
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai]
synonym: "nucleoside-sodium cotransporter activity" BROAD []
synonym: "sodium-dependent nucleoside transporter activity" BROAD []
xref: Reactome:R-HSA-109530 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1"
xref: Reactome:R-HSA-109538 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3"
xref: Reactome:R-HSA-109539 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2"
xref: Reactome:R-HSA-9751037 "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9754934 "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol"
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005416
name: amino acid:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]
synonym: "amino acid:cation symporter activity" BROAD []
synonym: "cation/amino acid symporter activity" EXACT []
synonym: "cation:amino acid symporter activity" EXACT []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity

[Term]
id: GO:0005427
name: proton-dependent oligopeptide secondary active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544]
synonym: "hydrogen/oligopeptide symporter" RELATED []
synonym: "proton-dependent oligopeptide transporter activity" EXACT []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005429
name: obsolete chromaffin granule amine transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of amines across chromaffin granule membranes." [GOC:mah]
comment: The term was obsoleted because its intended usage was unclear: chromaffin granules are dense core secretory vesicles (PMID:20853344) so whatever they transport must be by secretion.
is_obsolete: true

[Term]
id: GO:0005430
name: obsolete synaptic vesicle amine transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of amines across synaptic vesicle membranes." [GOC:ai]
comment: The class was obsoleted because the cellular location of a function should not be part of the class label.
is_obsolete: true
consider: GO:0005275

[Term]
id: GO:0005432
name: calcium:sodium antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]
synonym: "mitochondrial sodium/calcium ion exchange" RELATED []
synonym: "sodium/calcium exchanger" EXACT []
synonym: "sodium:calcium exchange" RELATED []
xref: Reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+"
xref: Reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)"
xref: Reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)"
xref: RHEA:29255
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015368 ! calcium:monoatomic cation antiporter activity

[Term]
id: GO:0005436
name: sodium:phosphate symporter activity
namespace: molecular_function
alt_id: GO:0015321
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [TC:2.A.1.14.6]
synonym: "sodium-dependent phosphate transmembrane transporter activity" RELATED []
synonym: "sodium/phosphate symporter activity" EXACT []
xref: Reactome:R-HSA-2872498 "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol"
xref: Reactome:R-HSA-427605 "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-427645 "SLC34A3 cotransports Pi, 2Na+"
xref: Reactome:R-HSA-427656 "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-428609 "Type I Na+-coupled phosphate co-transport"
xref: Reactome:R-HSA-5625123 "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5651685 "Defective SLC34A1 does not cotransport Pi, 3Na+"
xref: Reactome:R-HSA-5651697 "Defective SLC34A2 does not cotransport Pi, 3Na+"
xref: Reactome:R-HSA-5651971 "Defective SLC34A3 does not cotransport Pi, 2Na+"
xref: Reactome:R-HSA-5687585 "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol"
xref: TC:2.A.1.14.6
is_a: GO:0005315 ! phosphate transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005451
name: obsolete monoatomic cation:proton antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + H+(in) = monoatomic cation(in) + H+(out)." [GOC:ai]
comment: This term was obsoleted because it represents an unnecessary grouping term.
synonym: "monovalent cation:hydrogen antiporter activity" EXACT []
synonym: "monovalent cation:proton antiporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0005452
name: solute:inorganic anion antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]
synonym: "inorganic anion exchanger activity" EXACT []
xref: Reactome:R-HSA-1237038 "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-"
xref: Reactome:R-HSA-1247665 "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-"
xref: Reactome:R-HSA-425482 "SLC4A1,2,3 exchanges HCO3- for Cl-"
xref: Reactome:R-HSA-425577 "Na+-driven Cl-/HCO3- exchanger transport"
xref: Reactome:R-HSA-427666 "SLC26A3,6 exchange Cl- for HCO3-"
xref: Reactome:R-HSA-5627737 "SLC26A3 does not exchange Cl- for HCO3-"
xref: Reactome:R-HSA-5656248 "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes)"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005456
name: CMP-N-acetylneuraminate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "CMP-sialic acid transmembrane transporter activity" BROAD []
xref: Reactome:R-HSA-5651942 "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP"
xref: Reactome:R-HSA-727807 "SLC35A1 exchanges CMP-Neu5Ac for CMP"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005457
name: GDP-fucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-5653596 "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen"
xref: Reactome:R-HSA-742345 "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen"
is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005458
name: GDP-mannose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005459
name: UDP-galactose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-5652099 "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP"
xref: Reactome:R-HSA-735702 "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP"
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005460
name: UDP-glucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005461
name: UDP-glucuronic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-174368 "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen"
xref: Reactome:R-HSA-5603297 "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc"
xref: Reactome:R-HSA-9912889 "SLC35D2 exchanges UDP-GlcA for UMP"
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005462
name: UDP-N-acetylglucosamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-5653622 "Defective SLC35A3 does not exchange UDP-GlcNAc for UMP"
xref: Reactome:R-HSA-741450 "SLC35A3 exchanges UDP-GlcNAc for UMP"
xref: Reactome:R-HSA-742354 "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005463
name: UDP-N-acetylgalactosamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005464
name: UDP-xylose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]
xref: Reactome:R-HSA-742373 "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0005468
name: obsolete small-molecule carrier or transporter
namespace: molecular_function
alt_id: GO:0005453
alt_id: GO:0005454
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not provide a useful functional classification.
synonym: "small-molecule carrier or transporter" EXACT []
is_obsolete: true
consider: GO:0005215

[Term]
id: GO:0005469
name: succinate:fumarate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1]
xref: RHEA:29323
is_a: GO:0015138 ! fumarate transmembrane transporter activity
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005471
name: ATP:ADP antiporter activity
namespace: molecular_function
alt_id: GO:0005349
def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1]
synonym: "adenine nucleotide translocase" EXACT []
synonym: "ADP/ATP carrier protein" EXACT []
synonym: "ADP/ATP translocase" EXACT []
synonym: "ATP/ADP exchange" EXACT []
synonym: "ATP/ADP exchanger" EXACT []
xref: RHEA:34999
is_a: GO:0005347 ! ATP transmembrane transporter activity
is_a: GO:0015217 ! ADP transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005476
name: carnitine:acyl carnitine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458]
synonym: "carnitine/acyl carnitine carrier activity" EXACT []
synonym: "carnitine:acyl carnitine carrier activity" EXACT []
synonym: "fatty acyl carnitine carrier" EXACT []
xref: Reactome:R-HSA-200424 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane"
is_a: GO:0015226 ! carnitine transmembrane transporter activity
is_a: GO:0015227 ! acyl carnitine transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005477
name: pyruvate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
synonym: "pyruvate carrier activity" RELATED []
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity
is_a: GO:0050833 ! pyruvate transmembrane transporter activity

[Term]
id: GO:0005479
name: obsolete vacuolar assembly
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vacuolar assembly" EXACT []
is_obsolete: true
replaced_by: GO:0007033

[Term]
id: GO:0005480
name: obsolete vesicle transport
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vesicle transport" EXACT []
is_obsolete: true
replaced_by: GO:0016192

[Term]
id: GO:0005481
name: obsolete vesicle fusion
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vesicle fusion" EXACT []
is_obsolete: true
consider: GO:0006906
consider: GO:0007086
consider: GO:0016189
consider: GO:0016192
consider: GO:0019817

[Term]
id: GO:0005482
name: obsolete vesicle targeting
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vesicle targeting" EXACT []
is_obsolete: true
consider: GO:0006903
consider: GO:0016080

[Term]
id: GO:0005483
name: soluble NSF attachment protein activity
namespace: molecular_function
def: "Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]
synonym: "SNAP" EXACT []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0005484
name: SNAP receptor activity
namespace: molecular_function
alt_id: GO:0005485
alt_id: GO:0005486
def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
subset: goslim_chembl
synonym: "Q-SNARE activity" NARROW []
synonym: "R-SNARE activity" NARROW []
synonym: "SNAP-25" NARROW []
synonym: "SNARE" EXACT []
synonym: "t-SNARE activity" NARROW []
synonym: "v-SNARE activity" NARROW []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0005488
name: binding
namespace: molecular_function
def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]
subset: goslim_pir
subset: goslim_plant
synonym: "ligand" NARROW []
xref: Wikipedia:Binding_(molecular)
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005489
name: obsolete electron transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai]
comment: This term was made obsolete because the activity described by the definition does not exist.
synonym: "class I cytochrome c" RELATED []
synonym: "class II cytochrome c" RELATED []
synonym: "class IIa cytochrome c" RELATED []
synonym: "class IIb cytochrome c" RELATED []
synonym: "class III cytochrome c" RELATED []
synonym: "class IV cytochrome c" RELATED []
synonym: "cytochrome b" RELATED []
synonym: "cytochrome b5" RELATED []
synonym: "cytochrome c3 (tetraheme)" RELATED []
synonym: "cytochrome c554" RELATED []
synonym: "cytochrome c7 (triheme)" RELATED []
synonym: "cytochrome d" RELATED []
synonym: "diheme class I cytochrome c" RELATED []
synonym: "electron transfer carrier" RELATED []
synonym: "electron transporter activity" EXACT []
synonym: "flavin-containing electron transporter" RELATED []
synonym: "flavodoxin" RELATED []
synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED []
synonym: "monoheme class I cytochrome c" RELATED []
synonym: "nonaheme cytochrome c" RELATED []
synonym: "respiratory chain cytochrome b6" RELATED []
synonym: "Rieske iron-sulfur protein" RELATED []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0005490
name: obsolete cytochrome P450
namespace: molecular_function
def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684]
comment: This term was made obsolete because its definition was changed and because it represents a gene product.
synonym: "cytochrome P450" EXACT []
is_obsolete: true

[Term]
id: GO:0005496
name: steroid binding
namespace: molecular_function
def: "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0008289 ! lipid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0005497
name: androgen binding
namespace: molecular_function
def: "Binding to an androgen, a male sex hormone." [GOC:jl]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0005499
name: vitamin D binding
namespace: molecular_function
def: "Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309]
synonym: "calciferol binding" NARROW []
synonym: "cholecalciferol binding" NARROW []
synonym: "ergocalciferol binding" NARROW []
is_a: GO:0005496 ! steroid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0005500
name: juvenile hormone binding
namespace: molecular_function
def: "Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732]
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0005501
name: retinoid binding
namespace: molecular_function
def: "Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732]
xref: Reactome:R-HSA-2454113 "RBP3 transports 11cRAL to rod photoreceptor outer segment"
xref: Reactome:R-HSA-2464809 "RBP3 regulates the transport of atROL from ROS to RPE"
xref: Reactome:R-HSA-2465934 "11cROL translocates from Muller cells to cone photoreceptor cells"
xref: Reactome:R-HSA-2465938 "RBP3 regulates atROL taken up by Muller cells"
is_a: GO:0019840 ! isoprenoid binding

[Term]
id: GO:0005502
name: 11-cis retinal binding
namespace: molecular_function
def: "Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [PMID:24403072]
synonym: "11-cis retinaldehyde binding" EXACT []
synonym: "11-cis-retinal binding" NARROW []
synonym: "vitamin A binding" BROAD []
is_a: GO:0016918 ! retinal binding

[Term]
id: GO:0005503
name: all-trans retinal binding
namespace: molecular_function
def: "Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [GOC:curators]
synonym: "all-trans retinaldehyde binding" EXACT []
synonym: "trans retinal binding" EXACT []
synonym: "visual yellow binding" EXACT []
synonym: "vitamin A binding" BROAD []
synonym: "xanthopsin" RELATED []
is_a: GO:0016918 ! retinal binding

[Term]
id: GO:0005504
name: fatty acid binding
namespace: molecular_function
def: "Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]
is_a: GO:0008289 ! lipid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0005505
name: obsolete heavy metal binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal binding" EXACT []
is_obsolete: true
consider: GO:0046872

[Term]
id: GO:0005506
name: iron ion binding
namespace: molecular_function
def: "Binding to an iron (Fe) ion." [GOC:ai]
synonym: "iron binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0005507
name: copper ion binding
namespace: molecular_function
def: "Binding to a copper (Cu) ion." [GOC:ai]
synonym: "copper binding" EXACT []
synonym: "copper/cadmium binding" BROAD []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0005508
name: obsolete copper/cadmium binding
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a composite function.
synonym: "copper/cadmium binding" EXACT []
is_obsolete: true
consider: GO:0005507
consider: GO:0046870

[Term]
id: GO:0005509
name: calcium ion binding
namespace: molecular_function
def: "Binding to a calcium ion (Ca2+)." [GOC:ai]
synonym: "calcium ion storage activity" RELATED []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0005513
name: detection of calcium ion
namespace: biological_process
def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg]
synonym: "Ca2+ ion detection" EXACT []
synonym: "calcium ion detection" EXACT []
synonym: "calcium ion sensing" EXACT []
synonym: "detection of Ca2+ ion" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051592 ! response to calcium ion

[Term]
id: GO:0005514
name: obsolete calcium ion storage activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "calcium ion storage activity" EXACT []
is_obsolete: true
consider: GO:0005509
consider: GO:0051208

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0001948
alt_id: GO:0045308
def: "Binding to a protein." [GOC:go_curators]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "glycoprotein binding" NARROW []
synonym: "protein amino acid binding" EXACT []
xref: Reactome:R-HSA-9866132 "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH"
is_a: GO:0005488 ! binding

[Term]
id: GO:0005516
name: calmodulin binding
namespace: molecular_function
def: "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
subset: goslim_chembl
xref: Reactome:R-HSA-202110 "eNOS:Caveolin-1 complex binds to CaM"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005517
name: obsolete calmodulin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'.
synonym: "calmodulin inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0005516

[Term]
id: GO:0005518
name: collagen binding
namespace: molecular_function
def: "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0005519
name: cytoskeletal regulatory protein binding
namespace: molecular_function
def: "Binding to a protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0005520
name: insulin-like growth factor binding
namespace: molecular_function
def: "Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]
subset: goslim_chembl
synonym: "IGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0005521
name: lamin binding
namespace: molecular_function
def: "Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732]
synonym: "lamin/chromatin binding" BROAD []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005522
name: profilin binding
namespace: molecular_function
def: "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005523
name: tropomyosin binding
namespace: molecular_function
def: "Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0005524
name: ATP binding
namespace: molecular_function
def: "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
synonym: "Mg-ATP binding" EXACT []
synonym: "MgATP binding" EXACT []
xref: Reactome:R-HSA-265682 "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel"
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding

[Term]
id: GO:0005525
name: GTP binding
namespace: molecular_function
def: "Binding to GTP, guanosine triphosphate." [GOC:ai]
xref: Reactome:R-HSA-167429 "The receptor:G-protein complex  binds GTP"
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding

[Term]
id: GO:0005527
name: macrolide binding
namespace: molecular_function
def: "Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732]
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0005528
name: FK506 binding
namespace: molecular_function
def: "Binding to a 23-membered macrolide lactone FK506." [GOC:jl]
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED []
is_a: GO:0005527 ! macrolide binding
is_a: GO:0033218 ! amide binding

[Term]
id: GO:0005530
name: obsolete lectin
namespace: molecular_function
def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [GOC:curators]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0030246

[Term]
id: GO:0005531
name: obsolete galactose binding lectin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "galactose binding lectin" EXACT []
is_obsolete: true
consider: GO:0005534
consider: GO:0007157

[Term]
id: GO:0005532
name: obsolete mannose binding lectin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "mannose binding lectin" EXACT []
synonym: "mannose receptor" RELATED []
is_obsolete: true
consider: GO:0005537
consider: GO:0007157

[Term]
id: GO:0005533
name: obsolete N-acetylgalactosamine lectin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "N-acetylgalactosamine lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0046871

[Term]
id: GO:0005534
name: galactose binding
namespace: molecular_function
def: "Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [GOC:jl, ISBN:0198506732]
synonym: "galactose binding lectin" RELATED []
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005536
name: D-glucose binding
namespace: molecular_function
def: "Binding to D-enantiomers of glucose." [GOC:jl]
synonym: "glucose binding" BROAD []
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005537
name: D-mannose binding
namespace: molecular_function
def: "Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981]
subset: goslim_chembl
synonym: "mannose binding" BROAD []
synonym: "mannose binding lectin" RELATED []
xref: Reactome:R-HSA-947991 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi"
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005539
name: glycosaminoglycan binding
namespace: molecular_function
def: "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0005540
name: hyaluronic acid binding
namespace: molecular_function
def: "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl]
synonym: "hyaluronan binding" EXACT []
is_a: GO:0005539 ! glycosaminoglycan binding

[Term]
id: GO:0005541
name: obsolete acyl-CoA or acyl binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it was replaced by more appropriate terms.
synonym: "acyl-CoA or acyl binding" EXACT []
is_obsolete: true
consider: GO:0000035
consider: GO:0000062

[Term]
id: GO:0005542
name: folic acid binding
namespace: molecular_function
def: "Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732]
synonym: "folate binding" EXACT []
synonym: "vitamin B9 binding" EXACT []
synonym: "vitamin M binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0033218 ! amide binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0005543
name: phospholipid binding
namespace: molecular_function
def: "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0005544
name: calcium-dependent phospholipid binding
namespace: molecular_function
def: "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0005545
name: 1-phosphatidylinositol binding
namespace: molecular_function
def: "Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]
is_a: GO:0035091 ! phosphatidylinositol binding

[Term]
id: GO:0005546
name: phosphatidylinositol-4,5-bisphosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding" EXACT []
synonym: "phosphatidylinositol 4,5-bisphosphate binding" EXACT [GOC:ebc]
synonym: "PIP2 binding" BROAD []
synonym: "PtdIns(4,5)P2 binding" EXACT [GOC:bf]
is_a: GO:0043168 ! anion binding
is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding

[Term]
id: GO:0005547
name: phosphatidylinositol-3,4,5-trisphosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
synonym: "PIP3 binding" EXACT [GOC:bf]
is_a: GO:0043168 ! anion binding
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0005548
name: phospholipid transporter activity
namespace: molecular_function
alt_id: GO:0008497
def: "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732]
xref: Reactome:R-HSA-216757 "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane"
xref: Reactome:R-HSA-382553 "ABCA7:Apo1A-mediated phospholipid efflux"
xref: Reactome:R-HSA-5678706 "ABCB4 transports PC from plasma membrane to extracellular region"
xref: Reactome:R-HSA-5678749 "Defective ABCB4 does not transport PC from plasma membrane to extracellular region"
xref: Reactome:R-HSA-8857662 "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane"
xref: Reactome:R-HSA-8865637 "MFSD2A transports LPC from extracellular region to plasma membrane"
xref: Reactome:R-HSA-8867876 "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane"
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0005549
name: odorant binding
namespace: molecular_function
def: "Binding to an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0005550
name: pheromone binding
namespace: molecular_function
def: "Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]
is_a: GO:0005549 ! odorant binding

[Term]
id: GO:0005551
name: obsolete ubiquitin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0016567
consider: GO:0031386

[Term]
id: GO:0005552
name: obsolete polyubiquitin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "polyubiquitin" EXACT []
is_obsolete: true
consider: GO:0000209

[Term]
id: GO:0005553
name: obsolete ubiquitin-ribosomal protein fusion protein
namespace: molecular_function
def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732]
comment: This term was made obsolete because it describes a gene product.
synonym: "ubiquitin-ribosomal protein fusion protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005555
name: obsolete blood group antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "blood group antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0005557
name: obsolete lymphocyte antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "lymphocyte antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0005558
name: obsolete minor histocompatibility antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "minor histocompatibility antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0005559
name: obsolete ribozyme
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "ribozyme" EXACT []
is_obsolete: true

[Term]
id: GO:0005561
name: obsolete nucleic acid
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "nucleic acid" EXACT []
is_obsolete: true

[Term]
id: GO:0005562
name: obsolete RNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005563
name: obsolete transfer RNA
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "transfer RNA" EXACT []
is_obsolete: true
replaced_by: GO:0030533

[Term]
id: GO:0005564
name: obsolete cytosolic tRNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "cytosolic tRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005565
name: obsolete mitochondrial tRNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "mitochondrial tRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005566
name: obsolete ribosomal RNA
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "ribosomal RNA" EXACT []
is_obsolete: true
consider: GO:0003735
consider: GO:0005840

[Term]
id: GO:0005567
name: obsolete cytosolic ribosomal RNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "cytosolic ribosomal RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005568
name: obsolete mitochondrial rRNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "mitochondrial rRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005569
name: obsolete small nucleolar RNA
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents gene products.
synonym: "small nucleolar RNA" EXACT []
is_obsolete: true
consider: GO:0030555

[Term]
id: GO:0005570
name: obsolete small nuclear RNA
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents gene products.
synonym: "small nuclear RNA" EXACT []
is_obsolete: true
consider: GO:0000375
consider: GO:0017069

[Term]
id: GO:0005571
name: obsolete untranslated RNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "untranslated RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005572
name: obsolete RNA polymerase II transcribed untranslated RNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "RNA polymerase II transcribed untranslated RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005573
name: obsolete telomerase RNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a gene product.
synonym: "telomerase RNA" EXACT []
is_obsolete: true
replaced_by: GO:0000332

[Term]
id: GO:0005574
name: obsolete DNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "DNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell or subcellular entity" EXACT []
synonym: "cellular component" EXACT []
synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315]
xref: NIF_Subcellular:sao1337158144

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0005577
name: fibrinogen complex
namespace: cellular_component
def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684]
synonym: "fibrinogen" EXACT []
synonym: "fibrinogen alpha chain" NARROW []
synonym: "fibrinogen beta chain" NARROW []
synonym: "fibrinogen gamma chain" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005579
name: membrane attack complex
namespace: cellular_component
def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149]
synonym: "MAC" EXACT []
synonym: "membrane attack complex protein alphaM chain" NARROW []
synonym: "membrane attack complex protein beta2 chain" NARROW []
synonym: "TCC" EXACT []
synonym: "terminal complement complex" EXACT []
xref: Wikipedia:Complement_membrane_attack_complex
is_a: GO:0046930 ! pore complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0005580
name: obsolete membrane attack complex protein alphaM chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "membrane attack complex protein alphaM chain" EXACT []
is_obsolete: true
replaced_by: GO:0005579

[Term]
id: GO:0005581
name: collagen trimer
namespace: cellular_component
def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0005582
name: collagen type XV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils." [PMID:11158616, PMID:11937714, PMID:21421911]
is_a: GO:0098651 ! basement membrane collagen trimer

[Term]
id: GO:0005583
name: fibrillar collagen trimer
namespace: cellular_component
def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
relationship: part_of GO:0098643 ! banded collagen fibril

[Term]
id: GO:0005584
name: collagen type I trimer
namespace: cellular_component
def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976]
xref: Wikipedia:Collagen_type_I
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005585
name: collagen type II trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976]
xref: Wikipedia:Collagen_type_II
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005586
name: collagen type III trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005587
name: collagen type IV trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen_type_IV
is_a: GO:0098642 ! network-forming collagen trimer
is_a: GO:0098651 ! basement membrane collagen trimer

[Term]
id: GO:0005588
name: collagen type V trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005589
name: collagen type VI trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976, PMID:19693541, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
relationship: part_of GO:0098647 ! collagen beaded filament

[Term]
id: GO:0005590
name: collagen type VII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin." [ISBN:0721639976, PMID:19693541]
is_a: GO:0030934 ! anchoring collagen complex
relationship: part_of GO:0098652 ! collagen type VII anchoring fibril

[Term]
id: GO:0005591
name: collagen type VIII trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976, PMID:21421911]
is_a: GO:0005598 ! short-chain collagen trimer
is_a: GO:0030935 ! sheet-forming collagen trimer
is_a: GO:0098651 ! basement membrane collagen trimer

[Term]
id: GO:0005592
name: collagen type XI trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005593
name: FACIT collagen trimer
namespace: cellular_component
def: "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences." [ISBN:0198599587, PMID:21421911]
comment: The acronym FACIT stands for fibril-associated collagen with interrupted triple helix.
xref: Wikipedia:FACIT_collagen
is_a: GO:0005581 ! collagen trimer

[Term]
id: GO:0005594
name: collagen type IX trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen trimer

[Term]
id: GO:0005595
name: collagen type XII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen trimer
is_a: GO:0030934 ! anchoring collagen complex

[Term]
id: GO:0005596
name: collagen type XIV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen trimer
is_a: GO:0030934 ! anchoring collagen complex

[Term]
id: GO:0005597
name: collagen type XVI trimer
namespace: cellular_component
def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140]
is_a: GO:0005593 ! FACIT collagen trimer

[Term]
id: GO:0005598
name: short-chain collagen trimer
namespace: cellular_component
def: "Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils." [ISBN:0198599587]
is_a: GO:0005581 ! collagen trimer

[Term]
id: GO:0005599
name: collagen type X trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets)." [ISBN:0721639976, PMID:21421911]
comment: Collagen X trimers have been observed to form hexagonal lattices in vitro, but in vivo they have been found in a fibril associated form (PMID:19693541).
is_a: GO:0005598 ! short-chain collagen trimer
is_a: GO:0030935 ! sheet-forming collagen trimer

[Term]
id: GO:0005600
name: collagen type XIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane." [GOC:bhm, GOC:dos, ISBN:0721639976]
is_a: GO:0030936 ! transmembrane collagen trimer

[Term]
id: GO:0005601
name: classical-complement-pathway C3/C5 convertase complex
namespace: cellular_component
def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [GOC:mah]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005602
name: complement component C1 complex
namespace: cellular_component
def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149]
synonym: "complement component C1q complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0005603
name: obsolete complement component C2 complex
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entity corresponding to "complement C2 complex".
synonym: "complement component C2 complex" EXACT []
is_obsolete: true

[Term]
id: GO:0005604
name: basement membrane
namespace: cellular_component
alt_id: GO:0005605
alt_id: GO:0008003
def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]
comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer.
synonym: "basal lamina" RELATED []
synonym: "basement lamina" RELATED []
synonym: "lamina densa" RELATED []
xref: Wikipedia:Basement_membrane
is_a: GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0005606
name: laminin-1 complex
namespace: cellular_component
def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-111 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005607
name: laminin-2 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-211 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005608
name: laminin-3 complex
namespace: cellular_component
def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761]
synonym: "laminin-121 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005609
name: laminin-4 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-221 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005610
name: laminin-5 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-332 complex" NARROW [GOC:dph, PMID:15979864]
synonym: "laminin-3A32 complex" EXACT [PMID:15979864]
synonym: "laminin-5A complex" EXACT [PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005611
name: laminin-6 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-311 complex" EXACT [GOC:dph, PMID:15979864]
synonym: "laminin-6A complex" EXACT [PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005612
name: laminin-7 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-321 complex" NARROW [GOC:dph, PMID:15979864]
synonym: "laminin-7A" EXACT [PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005613
name: obsolete laminin receptor protein
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family.
synonym: "laminin receptor protein" EXACT []
is_obsolete: true
consider: GO:0008305

[Term]
id: GO:0005614
name: interstitial matrix
namespace: cellular_component
def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001]
is_a: GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0005615
name: extracellular space
namespace: cellular_component
def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
synonym: "intercellular space" RELATED []
xref: NIF_Subcellular:sao1425028079
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0005616
name: larval serum protein complex
namespace: cellular_component
def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005617
name: obsolete larval serum protein-1
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "larval serum protein-1" EXACT []
synonym: "LSP1" EXACT []
is_obsolete: true

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, ISBN:0198547684, PMID:15134259, Wikipedia:Microbial_cyst]
comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995).
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
xref: Wikipedia:Cell_wall
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0005619
name: ascospore wall
namespace: cellular_component
def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568]
synonym: "fungal-type spore wall" BROAD [GOC:mah]
is_a: GO:0009277 ! fungal-type cell wall
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0005621
name: cellular bud scar
namespace: cellular_component
def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0005622
name: intracellular anatomical structure
namespace: cellular_component
def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
synonym: "internal to cell" EXACT []
synonym: "intracellular" EXACT []
synonym: "nucleocytoplasm" RELATED [GOC:mah]
synonym: "protoplasm" EXACT []
synonym: "protoplast" RELATED [GOC:mah]
xref: Wikipedia:Intracellular
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0005623
name: obsolete cell
namespace: cellular_component
def: "OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators]
comment: This term was obsoleted because it was redundant with the root class of the cell ontology, CL:0000000.
xref: NIF_Subcellular:sao1813327414
xref: Wikipedia:Cell_(biology)
is_obsolete: true

[Term]
id: GO:0005624
name: obsolete membrane fraction
namespace: cellular_component
def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "membrane fraction" EXACT []
is_obsolete: true
consider: GO:0016020

[Term]
id: GO:0005625
name: obsolete soluble fraction
namespace: cellular_component
def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "soluble" BROAD []
synonym: "soluble fraction" EXACT []
is_obsolete: true
consider: GO:0005575

[Term]
id: GO:0005626
name: obsolete insoluble fraction
namespace: cellular_component
def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "insoluble fraction" EXACT []
synonym: "particle-bound" RELATED []
is_obsolete: true
consider: GO:0005575

[Term]
id: GO:0005627
name: obsolete ascus
namespace: cellular_component
def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684]
comment: This term was made obsolete because it is a structure that contains cell (ascospores) rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'.
synonym: "ascus" EXACT []
is_obsolete: true

[Term]
id: GO:0005628
name: prospore membrane
namespace: cellular_component
def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649]
synonym: "ascospore-type prospore membrane" EXACT [GOC:mah]
synonym: "forespore membrane" RELATED []
synonym: "FSM" EXACT []
is_a: GO:0016020 ! membrane
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0005630
name: dityrosine layer of spore wall
namespace: cellular_component
def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005631
name: chitosan layer of spore wall
namespace: cellular_component
def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005632
name: inner layer of spore wall
namespace: cellular_component
def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005633
name: ascus lipid droplet
namespace: cellular_component
def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293]
synonym: "ascus lipid particle" EXACT []
is_a: GO:0005811 ! lipid droplet

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757]
xref: NIF_Subcellular:sao1702920020
xref: Wikipedia:Cell_nucleus
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0005635
name: nuclear envelope
namespace: cellular_component
alt_id: GO:0005636
def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: Wikipedia:Nuclear_envelope
is_a: GO:0031967 ! organelle envelope
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005637
name: nuclear inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]
synonym: "inner envelope" BROAD []
synonym: "inner nuclear membrane" EXACT [GOC:kmv, GOC:vw, PMID:21411627]
synonym: "nucleus inner membrane" EXACT []
xref: NIF_Subcellular:sao1612527463
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031965 ! nuclear membrane

[Term]
id: GO:0005638
name: lamin filament
namespace: cellular_component
def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684]
synonym: "type V intermediate filament" EXACT []
is_a: GO:0005882 ! intermediate filament
relationship: part_of GO:0005652 ! nuclear lamina

[Term]
id: GO:0005639
name: obsolete integral component of nuclear inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to nuclear inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005637

[Term]
id: GO:0005640
name: nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]
synonym: "nucleus outer envelope" EXACT []
synonym: "perinuclear membrane" EXACT []
xref: NIF_Subcellular:sao1617136075
is_a: GO:0031965 ! nuclear membrane
is_a: GO:0031968 ! organelle outer membrane
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network

[Term]
id: GO:0005641
name: nuclear envelope lumen
namespace: cellular_component
alt_id: GO:0005653
def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai]
comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
synonym: "nuclear intermembrane space" EXACT []
synonym: "nuclear membrane lumen" RELATED []
synonym: "perinuclear space" EXACT []
is_a: GO:0031970 ! organelle envelope lumen
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0005642
name: annulate lamellae
namespace: cellular_component
def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728]
is_a: GO:0016020 ! membrane
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network

[Term]
id: GO:0005643
name: nuclear pore
namespace: cellular_component
alt_id: GO:0005644
def: "A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
subset: goslim_pir
synonym: "NPC" EXACT []
synonym: "nuclear pore complex" EXACT []
synonym: "nuclear pore membrane protein" NARROW []
synonym: "nucleopore" EXACT [GOC:al, PMID:7603572]
xref: NIF_Subcellular:sao220861693
xref: Wikipedia:Nuclear_pore
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0005645
name: obsolete RAN-binding protein
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "RAN-binding protein" EXACT []
is_obsolete: true
replaced_by: GO:0031267

[Term]
id: GO:0005646
name: obsolete importin
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "importin" EXACT []
synonym: "karyopherin" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737
consider: GO:0017056

[Term]
id: GO:0005647
name: obsolete importin, alpha-subunit
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "importin, alpha-subunit" EXACT []
synonym: "karyopherin-alpha" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737
consider: GO:0017056

[Term]
id: GO:0005648
name: obsolete importin, beta-subunit
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "importin, beta-subunit" EXACT []
synonym: "karyopherin-beta1" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737
consider: GO:0017056

[Term]
id: GO:0005649
name: obsolete transportin
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "karyopherin-beta2" EXACT []
synonym: "transportin" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005650
name: obsolete importin, alpha-subunit transport factor
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "CAS" RELATED []
synonym: "importin, alpha-subunit transport factor" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005651
name: obsolete exportin
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "exportin" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737
consider: GO:0017056

[Term]
id: GO:0005652
name: nuclear lamina
namespace: cellular_component
def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
xref: NIF_Subcellular:sao1455996588
xref: Wikipedia:Nuclear_lamina
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0034399 ! nuclear periphery

[Term]
id: GO:0005654
name: nucleoplasm
namespace: cellular_component
def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: NIF_Subcellular:sao661522542
xref: Wikipedia:Nucleoplasm
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005655
name: nucleolar ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
synonym: "nucleolar RNase P complex" EXACT []
is_a: GO:0030681 ! multimeric ribonuclease P complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0005656
name: nuclear pre-replicative complex
namespace: cellular_component
def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894]
synonym: "eukaryotic pre-replicative complex" EXACT [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "pre-RC" RELATED []
synonym: "pre-replicative complex" BROAD [GOC:bf, GOC:bhm, GOC:jh2]
is_a: GO:0036387 ! pre-replicative complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0005657
name: replication fork
namespace: cellular_component
def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]
synonym: "replication focus" RELATED []
xref: Wikipedia:Replication_fork
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0005658
name: alpha DNA polymerase:primase complex
namespace: cellular_component
def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377]
synonym: "DNA polymerase alpha:primase complex" EXACT []
synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT []
synonym: "pol-prim" RELATED []
synonym: "primosome" BROAD []
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0005660
name: obsolete delta-DNA polymerase cofactor complex
namespace: cellular_component
def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl]
comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature.
synonym: "delta DNA polymerase cofactor complex" EXACT []
synonym: "delta-DNA polymerase cofactor complex" EXACT []
is_obsolete: true
consider: GO:0005663
consider: GO:0043626

[Term]
id: GO:0005662
name: DNA replication factor A complex
namespace: cellular_component
def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]
synonym: "replication protein A" EXACT []
synonym: "RPA" EXACT []
xref: Wikipedia:Replication_protein_A
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0005663
name: DNA replication factor C complex
namespace: cellular_component
def: "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520]
subset: goslim_pir
synonym: "activator 1 complex" EXACT []
synonym: "RFC complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0005664
name: nuclear origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]
synonym: "eukaryotic ORC" EXACT []
synonym: "nuclear ORC" EXACT []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0005665
name: RNA polymerase II, core complex
namespace: cellular_component
def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "DNA-directed RNA polymerase II, core complex" EXACT []
synonym: "RNA polymerase II complex" BROAD []
synonym: "RNAP II complex" BROAD []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0005666
name: RNA polymerase III complex
namespace: cellular_component
def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "DNA-directed RNA polymerase III activity" RELATED []
synonym: "DNA-directed RNA polymerase III complex" EXACT []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0005667
name: transcription regulator complex
namespace: cellular_component
alt_id: GO:0044797
alt_id: GO:0044798
def: "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
subset: goslim_pir
synonym: "cytoplasmic transcription factor complex" RELATED []
synonym: "nuclear transcription factor complex" RELATED []
synonym: "transcription factor complex" RELATED []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0005668
name: RNA polymerase transcription factor SL1 complex
namespace: cellular_component
def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654]
synonym: "selectivity factor SL1 complex" EXACT [GOC:mah]
synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654]
is_a: GO:0000120 ! RNA polymerase I transcription regulator complex

[Term]
id: GO:0005669
name: transcription factor TFIID complex
namespace: cellular_component
def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0005670
name: obsolete transcription-activating factor, 30kD
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "transcription-activating factor, 30kD" EXACT []
is_obsolete: true
replaced_by: GO:0005669

[Term]
id: GO:0005671
name: obsolete Ada2/Gcn5/Ada3 transcription activator complex
namespace: cellular_component
alt_id: GO:0002928
def: "OBSOLETE. A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607]
comment: This term was obsoleted because it was incorrectly annotated. Consider ADA complex ; GO:0140671 or ATAC complex; GO:0140672.
synonym: "ATAC complex" RELATED [GOC:rl, PMID:18838386]
is_obsolete: true
consider: GO:0140671
consider: GO:0140672

[Term]
id: GO:0005672
name: transcription factor TFIIA complex
namespace: cellular_component
def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0005673
name: transcription factor TFIIE complex
namespace: cellular_component
def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0005674
name: transcription factor TFIIF complex
namespace: cellular_component
def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0005675
name: transcription factor TFIIH holo complex
namespace: cellular_component
def: "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
synonym: "holo TFIIH complex" EXACT []
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0005677
name: chromatin silencing complex
namespace: cellular_component
def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0005678
name: obsolete chromatin assembly complex
namespace: cellular_component
def: "OBSOLETE. Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah]
comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge.
synonym: "chromatin assembly complex" EXACT []
synonym: "nucleosome assembly complex" NARROW []
is_obsolete: true

[Term]
id: GO:0005680
name: anaphase-promoting complex
namespace: cellular_component
def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
synonym: "anaphase promoting complex" EXACT []
synonym: "APC" BROAD []
synonym: "cyclosome" EXACT []
xref: Wikipedia:Anaphase-promoting_complex
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0005681
name: spliceosomal complex
namespace: cellular_component
def: "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
subset: goslim_pir
synonym: "spliceosome" BROAD []
synonym: "spliceosome complex" EXACT []
xref: Wikipedia:Spliceosome
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0005682
name: U5 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "snRNP U5" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005683
name: U7 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004]
synonym: "snRNP U7" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005684
name: U2-type spliceosomal complex
namespace: cellular_component
def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900]
comment: A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP.
synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0005685
name: U1 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "snRNP U1" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005686
name: U2 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
comment: U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself.
synonym: "17S U2 snRNP" NARROW []
synonym: "snRNP U2" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005687
name: U4 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "snRNP U4" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005688
name: U6 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "snRNP U6" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005689
name: U12-type spliceosomal complex
namespace: cellular_component
def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]
synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah]
synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah]
xref: Wikipedia:Minor_spliceosome
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0005690
name: U4atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "snRNP U4atac" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005691
name: U6atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "snRNP U6atac" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005692
name: U11 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "12S U11 snRNP" NARROW []
synonym: "snRNP U11" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005693
name: U12 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U12, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U12 snRNP, most of which remain associated with the U12 snRNA both while the U12 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "snRNP U12" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0005695
name: obsolete chromatid
namespace: cellular_component
def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732]
comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions.
synonym: "chromatid" EXACT []
is_obsolete: true
consider: GO:0000793
consider: GO:0000794
consider: GO:0005694

[Term]
id: GO:0005696
name: obsolete telomere
namespace: cellular_component
def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732, PMID:11352055]
comment: This term was made obsolete because the definition was too sequence oriented and too restrictive.
synonym: "telomere" EXACT []
is_obsolete: true
consider: GO:0000781
consider: GO:0000782

[Term]
id: GO:0005697
name: telomerase holoenzyme complex
namespace: cellular_component
def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619]
subset: goslim_pir
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902494 ! catalytic complex
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0005698
name: obsolete centromere
namespace: cellular_component
def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732]
comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization.
synonym: "centromere" EXACT []
is_obsolete: true
consider: GO:0000775

[Term]
id: GO:0005700
name: polytene chromosome
namespace: cellular_component
def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
xref: Wikipedia:Polytene_chromosome
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0005701
name: polytene chromosome chromocenter
namespace: cellular_component
def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
synonym: "polytene chromosome chromocentre" EXACT []
is_a: GO:0010369 ! chromocenter
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005702
name: polytene chromosome weak point
namespace: cellular_component
def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012]
synonym: "constriction" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005703
name: polytene chromosome puff
namespace: cellular_component
def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005704
name: polytene chromosome band
namespace: cellular_component
def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005705
name: polytene chromosome interband
namespace: cellular_component
def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005706
name: polytene chromosome ectopic fiber
namespace: cellular_component
def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012]
synonym: "polytene chromosome ectopic fibre" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005707
name: obsolete interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "interphase chromosome" EXACT []
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0005708
name: obsolete mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process.
synonym: "mitotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000793
consider: GO:0000794

[Term]
id: GO:0005709
name: obsolete prophase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "prophase chromosome" EXACT []
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0005710
name: obsolete metaphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "metaphase chromosome" EXACT []
is_obsolete: true
consider: GO:0000793
consider: GO:0000794

[Term]
id: GO:0005711
name: obsolete meiotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process.
synonym: "meiotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000794

[Term]
id: GO:0005712
name: chiasma
namespace: cellular_component
def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732]
xref: Wikipedia:Chiasma_(genetics)
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005713
name: recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005714
name: early recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005715
name: late recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005721
name: pericentric heterochromatin
namespace: cellular_component
alt_id: GO:0002137
alt_id: GO:0031618
alt_id: GO:0034507
alt_id: GO:0062199
def: "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3)." [PMID:12019236, PMID:20206496, PMID:21437270, PMID:22729156, PMID:9413993]
synonym: "centric heterochromatin" EXACT []
synonym: "centromeric heterochromatin" EXACT [GOC:dph]
synonym: "chromosome, centric outer repeat region" RELATED []
synonym: "chromosome, centromeric inner repeat region" RELATED []
synonym: "chromosome, centromeric outer repeat region" RELATED []
synonym: "nuclear centric heterochromatin" NARROW []
synonym: "nuclear cluster" NARROW []
synonym: "nuclear pericentric heterochromatin" NARROW []
is_a: GO:0000792 ! heterochromatin
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0005722
name: beta-heterochromatin
namespace: cellular_component
def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678]
is_a: GO:0005721 ! pericentric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005723
name: alpha-heterochromatin
namespace: cellular_component
def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678]
is_a: GO:0005721 ! pericentric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005724
name: obsolete nuclear telomeric heterochromatin
namespace: cellular_component
def: "OBSOLETE. Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai]
comment: This term was obsoleted because there is no heterochromatin at the telomere and the term had been used inconsistently.
is_obsolete: true

[Term]
id: GO:0005725
name: intercalary heterochromatin
namespace: cellular_component
def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0005726
name: perichromatin fibrils
namespace: cellular_component
def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0005727
name: extrachromosomal circular DNA
namespace: cellular_component
def: "Circular DNA structures that are not part of a chromosome." [GOC:ai]
subset: goslim_metagenomics
is_a: GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0046821 ! extrachromosomal DNA

[Term]
id: GO:0005728
name: extrachromosomal rDNA circle
namespace: cellular_component
def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934]
synonym: "extrachromosomal ribosomal DNA circle" EXACT []
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005729
name: 2-micrometer circle DNA
namespace: cellular_component
def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320]
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: NIF_Subcellular:sao1820400233
xref: Wikipedia:Nucleolus
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005731
name: nucleolus organizer region
namespace: cellular_component
def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406]
synonym: "NOR" EXACT []
synonym: "nucleolus organiser region" EXACT []
synonym: "nucleolus organizer complex" RELATED []
xref: Wikipedia:Nucleolus_organizer_region
is_a: GO:0030874 ! nucleolar chromatin

[Term]
id: GO:0005732
name: sno(s)RNA-containing ribonucleoprotein complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA." [GOC:krc, GOC:mah, ISBN:0879695897, PMID:17284456]
comment: Note that 'nucleolar' in the name acronym 'snoRNA' is part of the RNA family designation 'small nucleolar', and does not reflect the location of the complex. Both box C/D type and box H/ACA RNAs are found in Archaea (where they are referred to as sRNAs) as well as in Eukaryota. In eukaryotes, box H/ACA RNAs are found in both nucleolar-localized snoRNP complexes and in Cajal body-localized scaRNP complexes.
subset: goslim_pir
synonym: "small nucleolar ribonucleoprotein" NARROW []
synonym: "small nucleolar ribonucleoprotein complex" NARROW []
synonym: "small ribonucleoprotein" NARROW []
synonym: "small ribonucleoprotein protein complex" NARROW []
synonym: "snoRNP" NARROW []
synonym: "sRNP" NARROW []
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0005733
name: obsolete small nucleolar RNA
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "small nucleolar RNA" EXACT []
synonym: "snoRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005734
name: obsolete box C + D snoRNP protein
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "box C + D snoRNP protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005735
name: obsolete box H + ACA snoRNP protein
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "box H + ACA snoRNP protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005736
name: RNA polymerase I complex
namespace: cellular_component
def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "DNA-directed RNA polymerase I activity" RELATED []
synonym: "DNA-directed RNA polymerase I complex" EXACT []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
xref: Wikipedia:Cytoplasm
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "mitochondria" EXACT []
xref: NIF_Subcellular:sao1860313010
xref: Wikipedia:Mitochondrion
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0031967 ! organelle envelope
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005741
name: mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
synonym: "mitochondrion outer membrane" EXACT []
synonym: "outer mitochondrial membrane" EXACT []
synonym: "outer mitochondrion membrane" EXACT []
xref: NIF_Subcellular:sao1289741256
xref: Wikipedia:Outer_mitochondrial_membrane
is_a: GO:0031966 ! mitochondrial membrane
is_a: GO:0031968 ! organelle outer membrane

[Term]
id: GO:0005742
name: mitochondrial outer membrane translocase complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]
synonym: "GIP complex" NARROW [PMID:23201437]
synonym: "mitochondrion outer membrane translocase complex" EXACT []
is_a: GO:0098799 ! outer mitochondrial membrane protein complex

[Term]
id: GO:0005743
name: mitochondrial inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
synonym: "inner mitochondrial membrane" EXACT []
synonym: "inner mitochondrion membrane" EXACT []
synonym: "mitochondrion inner membrane" EXACT []
xref: NIF_Subcellular:sao1371347282
xref: Wikipedia:Inner_mitochondrial_membrane
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0005744
name: TIM23 mitochondrial import inner membrane translocase complex
namespace: cellular_component
def: "The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [PMID:27554484, PMID:8851659]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
subset: goslim_pir
synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT []
synonym: "mitochondrial inner membrane presequence translocase complex" EXACT []
synonym: "mitochondrial inner membrane translocase complex" BROAD []
synonym: "Tim23 complex" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:0005745
name: m-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [GOC:mcc, PMID:12417197, PMID:21147776]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:0005746
name: obsolete mitochondrial respirasome
namespace: cellular_component
alt_id: GO:0097249
def: "OBSOLETE. The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "mitochondrial electron transport chain" EXACT []
synonym: "mitochondrial respiratory chain" EXACT []
synonym: "mitochondrial respiratory chain supercomplex" EXACT []
synonym: "mitochondrial respiratory supercomplex" EXACT []
is_obsolete: true
replaced_by: GO:0098803

[Term]
id: GO:0005747
name: obsolete mitochondrial respiratory chain complex I
namespace: cellular_component
alt_id: GO:0005748
def: "OBSOLETE. A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045271

[Term]
id: GO:0005749
name: obsolete mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
alt_id: GO:0008136
alt_id: GO:0009362
alt_id: GO:0019738
alt_id: GO:0030390
def: "OBSOLETE. A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, GOC:vw, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "mitochondrial fumarate reductase complex" EXACT []
is_obsolete: true
replaced_by: GO:0045273

[Term]
id: GO:0005750
name: obsolete mitochondrial respiratory chain complex III
namespace: cellular_component
alt_id: GO:0015008
def: "OBSOLETE. A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "mitochondrial coenzyme Q-cytochrome c oxidoreductase complex" EXACT []
synonym: "mitochondrial coenzyme Q-cytochrome c reductase complex" EXACT []
synonym: "mitochondrial complex III" EXACT [GOC:mcc]
synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc]
synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc]
synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc]
synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc]
synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc]
is_obsolete: true
replaced_by: GO:0045275

[Term]
id: GO:0005751
name: obsolete mitochondrial respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0005752
def: "OBSOLETE. A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045277

[Term]
id: GO:0005753
name: obsolete mitochondrial proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0016470
def: "OBSOLETE. A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "mitochondrial respiratory chain complex V" EXACT []
is_obsolete: true
replaced_by: GO:0045259

[Term]
id: GO:0005754
name: obsolete mitochondrial proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "OBSOLETE. The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045267

[Term]
id: GO:0005755
name: obsolete hydrogen-transporting ATP synthase, coupling factor CF(0)
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" EXACT []
is_obsolete: true
consider: GO:0045263

[Term]
id: GO:0005756
name: obsolete mitochondrial proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "OBSOLETE. One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045269

[Term]
id: GO:0005757
name: mitochondrial permeability transition pore complex
namespace: cellular_component
def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D)." [PMID:10393078]
synonym: "mitochondrial PT pore complex" EXACT []
synonym: "MPTP complex" EXACT []
synonym: "PTPC" BROAD [PMID:21760595]
is_a: GO:0046930 ! pore complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0005758
name: mitochondrial intermembrane space
namespace: cellular_component
alt_id: GO:0031971
def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
synonym: "mitochondrial envelope lumen" EXACT []
synonym: "mitochondrial membrane lumen" RELATED []
xref: NIF_Subcellular:sao118944228
is_a: GO:0031970 ! organelle envelope lumen
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0005759
name: mitochondrial matrix
namespace: cellular_component
alt_id: GO:0031980
def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
synonym: "mitochondrial lumen" EXACT []
synonym: "mitochondrial stroma" NARROW []
xref: NIF_Subcellular:sao1804523077
xref: Wikipedia:Mitochondrial_matrix
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005760
name: gamma DNA polymerase complex
namespace: cellular_component
def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005761
name: mitochondrial ribosome
namespace: cellular_component
def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732]
synonym: "55S ribosome, mitochondrial" NARROW []
is_a: GO:0000313 ! organellar ribosome
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005762
name: mitochondrial large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
synonym: "39S ribosomal subunit, mitochondrial" NARROW []
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005763
name: mitochondrial small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
synonym: "28S ribosomal subunit, mitochondrial" NARROW []
synonym: "mitochondrial ribosomal small subunit complex" EXACT []
synonym: "mitochondrial ribosomal SSU complex" EXACT []
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005764
name: lysosome
namespace: cellular_component
def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: NIF_Subcellular:sao585356902
xref: Wikipedia:Lysosome
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0005765
name: lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
synonym: "lysosome membrane" EXACT []
is_a: GO:0098852 ! lytic vacuole membrane
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0005766
name: primary lysosome
namespace: cellular_component
def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194]
xref: NIF_Subcellular:sao1140587416
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005767
name: secondary lysosome
namespace: cellular_component
def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194]
xref: NIF_Subcellular:sao1549842807
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005768
name: endosome
namespace: cellular_component
def: "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
xref: NIF_Subcellular:sao1720343330
xref: Wikipedia:Endosome
is_a: GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005769
name: early endosome
namespace: cellular_component
def: "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
xref: NIF_Subcellular:nlx_subcell_20090701
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005770
name: late endosome
namespace: cellular_component
def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
synonym: "prevacuolar compartment" EXACT []
synonym: "PVC" BROAD []
xref: NIF_Subcellular:nlx_subcell_20090702
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005771
name: multivesicular body
namespace: cellular_component
def: "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
synonym: "multivesicular endosome" EXACT [PMID:12122203]
synonym: "MVB" EXACT []
synonym: "MVE" EXACT [PMID:12122203]
xref: NIF_Subcellular:sao2045955158
is_a: GO:0005770 ! late endosome

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005774
name: vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0005775
name: vacuolar lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0005776
name: autophagosome
namespace: cellular_component
def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]
synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959]
synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959]
xref: NIF_Subcellular:sao8663416959
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0005777
name: peroxisome
namespace: cellular_component
alt_id: GO:0019818
def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "peroxisomal" RELATED []
synonym: "peroxisome vesicle" BROAD []
xref: NIF_Subcellular:sao499555322
xref: Wikipedia:Peroxisome
is_a: GO:0042579 ! microbody

[Term]
id: GO:0005778
name: peroxisomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a peroxisome." [GOC:mah]
synonym: "peroxisome membrane" EXACT []
is_a: GO:0031903 ! microbody membrane
relationship: part_of GO:0005777 ! peroxisome

[Term]
id: GO:0005779
name: obsolete integral component of peroxisomal membrane
namespace: cellular_component
def: "OBSOLETE. The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to peroxisomal membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005778

[Term]
id: GO:0005780
name: extrinsic component of intraperoxisomal membrane
namespace: cellular_component
def: "The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
synonym: "extrinsic to intraperoxisomal membrane" EXACT []
synonym: "intra-peroxisomal peripheral membrane" RELATED []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0005781
name: obsolete peroxisome targeting signal receptor complex
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric.
synonym: "peroxisome targeting signal receptor complex" EXACT []
is_obsolete: true
consider: GO:0000268
consider: GO:0006625

[Term]
id: GO:0005782
name: peroxisomal matrix
namespace: cellular_component
alt_id: GO:0031909
def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194]
synonym: "peroxisomal lumen" EXACT []
is_a: GO:0031907 ! microbody lumen
relationship: part_of GO:0005777 ! peroxisome

[Term]
id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "ER" EXACT []
xref: NIF_Subcellular:sao1036339110
xref: Wikipedia:Endoplasmic_reticulum
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005784
name: Sec61 translocon complex
namespace: cellular_component
def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647, PMID:32820719, PMID:33960686]
synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah]
is_a: GO:0071256 ! translocon complex

[Term]
id: GO:0005785
name: signal recognition particle receptor complex
namespace: cellular_component
def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732]
synonym: "docking protein complex" RELATED []
synonym: "SR complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0005786
name: signal recognition particle, endoplasmic reticulum targeting
namespace: cellular_component
alt_id: GO:0005855
def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732]
synonym: "signal sequence receptor complex" EXACT []
synonym: "SRP" EXACT []
xref: Wikipedia:Signal_recognition_particle
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0005787
name: signal peptidase complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1905370 ! serine-type endopeptidase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0005788
name: endoplasmic reticulum lumen
namespace: cellular_component
alt_id: GO:0016022
def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
synonym: "cisternal lumen" EXACT []
synonym: "endoplasmic reticulum cisterna" EXACT []
synonym: "ER cisterna" EXACT []
synonym: "ER lumen" EXACT []
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005789
name: endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
synonym: "ER membrane" EXACT []
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network
relationship: part_of GO:0098827 ! endoplasmic reticulum subcompartment

[Term]
id: GO:0005790
name: smooth endoplasmic reticulum
namespace: cellular_component
def: "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732]
synonym: "SER" EXACT []
synonym: "smooth ER" EXACT []
xref: NIF_Subcellular:sao710427438
xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005791
name: rough endoplasmic reticulum
namespace: cellular_component
def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]
synonym: "RER" EXACT []
synonym: "rough ER" EXACT []
xref: NIF_Subcellular:sao1881364067
xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005792
name: obsolete microsome
namespace: cellular_component
def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "microsomal membrane" RELATED []
synonym: "microsome" EXACT []
xref: Wikipedia:Microsome
is_obsolete: true
consider: GO:0043231

[Term]
id: GO:0005793
name: endoplasmic reticulum-Golgi intermediate compartment
namespace: cellular_component
def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]
synonym: "EGTC" EXACT []
synonym: "endoplasmic reticulum-Golgi transport container" EXACT []
synonym: "ER-Golgi intermediate compartment" EXACT []
synonym: "ER-Golgi transport container" EXACT []
synonym: "ERGIC" EXACT []
synonym: "pre-Golgi intermediate compartment" EXACT []
synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster]
synonym: "VTC" EXACT []
xref: Wikipedia:Vesicular-tubular_cluster
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: NIF_Subcellular:sao451912436
xref: Wikipedia:Golgi_apparatus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005795
name: Golgi stack
namespace: cellular_component
alt_id: GO:0016940
def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
synonym: "dictyosome" NARROW []
synonym: "Golgi cisternae" EXACT []
is_a: GO:0098791 ! Golgi apparatus subcompartment

[Term]
id: GO:0005796
name: Golgi lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah]
synonym: "Golgi apparatus lumen" EXACT []
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0005797
name: Golgi medial cisterna
namespace: cellular_component
def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
synonym: "Golgi apparatus medial cisterna" EXACT []
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0005798
name: Golgi-associated vesicle
namespace: cellular_component
def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
comment: Note that this definition includes vesicles that are transiently associated with the Golgi.
synonym: "Golgi vesicle" RELATED []
synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748]
xref: NIF_Subcellular:sao819927218
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0005799
name: obsolete coatomer
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself.
synonym: "coatomer" EXACT []
synonym: "COPI vesicle" RELATED []
is_obsolete: true
consider: GO:0030126
consider: GO:0030137

[Term]
id: GO:0005800
name: obsolete COPII vesicle
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "COPII vesicle" EXACT []
is_obsolete: true
consider: GO:0030134

[Term]
id: GO:0005801
name: cis-Golgi network
namespace: cellular_component
def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]
comment: The CGN is not considered part of the Golgi apparatus but is a separate organelle.
synonym: "cis face" BROAD [NIF_Subcellular:sao632188024]
synonym: "cis Golgi network" EXACT []
synonym: "forming face" RELATED []
synonym: "Golgi cis face" RELATED []
synonym: "Golgi cis-face" RELATED []
xref: NIF_Subcellular:sao632188024
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0005802
name: trans-Golgi network
namespace: cellular_component
def: "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
comment: There are different opinions about whether the TGN should be considered part of the Golgi apparatus or not. We follow Alberts et al, 1994 (ISBN:0815316194), who consider it to be a part.
synonym: "Golgi trans face" RELATED []
synonym: "Golgi trans-face" RELATED []
synonym: "late Golgi" RELATED [GOC:mah]
synonym: "maturing face" RELATED []
synonym: "TGN" EXACT []
synonym: "trans face" BROAD [NIF_Subcellular:sao1039242387]
synonym: "trans Golgi network" EXACT []
xref: NIF_Subcellular:sao9456487
is_a: GO:0098791 ! Golgi apparatus subcompartment

[Term]
id: GO:0005803
name: obsolete secretory vesicle
namespace: cellular_component
def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684]
comment: This term was made obsolete because it was being used to describe two different components.
synonym: "secretory vesicle" EXACT []
synonym: "transition vesicle" NARROW []
is_obsolete: true
consider: GO:0030133
consider: GO:0030141

[Term]
id: GO:0005804
name: obsolete secretory vesicle membrane
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its parent was made obsolete.
synonym: "secretory vesicle membrane" EXACT []
is_obsolete: true
consider: GO:0030658
consider: GO:0030667

[Term]
id: GO:0005805
name: obsolete ER-Golgi transport vesicle
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "ER-Golgi transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030134

[Term]
id: GO:0005806
name: obsolete Golgi-ER transport vesicle
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "Golgi-ER transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030142

[Term]
id: GO:0005808
name: obsolete Golgi-plasma membrane transport vesicle
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles.
synonym: "Golgi-plasma membrane transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030133

[Term]
id: GO:0005809
name: obsolete Golgi-vacuole transport vesicle
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "Golgi-vacuole transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030133

[Term]
id: GO:0005810
name: obsolete endocytotic transport vesicle
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "endocytotic transport vesicle" EXACT []
is_obsolete: true
replaced_by: GO:0030139

[Term]
id: GO:0005811
name: lipid droplet
namespace: cellular_component
def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.
subset: goslim_chembl
subset: goslim_generic
synonym: "adiposome" EXACT []
synonym: "lipid body" EXACT []
synonym: "lipid particle" EXACT []
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0005813
name: centrosome
namespace: cellular_component
def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
subset: goslim_pir
xref: Wikipedia:Centrosome
is_a: GO:0005815 ! microtubule organizing center

[Term]
id: GO:0005814
name: centriole
namespace: cellular_component
def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
synonym: "daughter centriole" NARROW [GOC:cilia]
synonym: "mother centriole" NARROW [GOC:cilia]
xref: NIF_Subcellular:sao95019936
xref: Wikipedia:Centriole
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005815 ! microtubule organizing center

[Term]
id: GO:0005815
name: microtubule organizing center
namespace: cellular_component
def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_yeast
synonym: "microtubule organising centre" EXACT []
synonym: "MTOC" EXACT []
xref: Wikipedia:Microtubule_organizing_center
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005816
name: spindle pole body
namespace: cellular_component
def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568]
synonym: "SPB" EXACT [GOC:mah]
xref: Wikipedia:Spindle_pole_body
is_a: GO:0005815 ! microtubule organizing center

[Term]
id: GO:0005817
name: obsolete centrosomal mitotic factor
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:clt]
comment: This term was made obsolete because it was not defined.
synonym: "centrosomal mitotic factor" EXACT []
is_obsolete: true

[Term]
id: GO:0005818
name: aster
namespace: cellular_component
def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt]
is_a: GO:0043232 ! intracellular membraneless organelle
is_a: GO:0099080 ! supramolecular complex
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005819
name: spindle
namespace: cellular_component
def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
xref: Wikipedia:Spindle_apparatus
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005821
name: intermediate layer of spindle pole body
namespace: cellular_component
def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005822
name: inner plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005823
name: central plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005824
name: outer plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005825
name: half bridge of spindle pole body
namespace: cellular_component
def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005826
name: actomyosin contractile ring
namespace: cellular_component
alt_id: GO:0030480
def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, GOC:vw, ISBN:0805319409, ISBN:0815316194, PMID:28914606]
synonym: "actomyosin ring" RELATED []
synonym: "CAR" EXACT []
synonym: "constriction ring" RELATED []
synonym: "contractile actomyosin ring" EXACT []
synonym: "cytokinetic ring" RELATED []
is_a: GO:0070938 ! contractile ring
relationship: part_of GO:0030864 ! cortical actin cytoskeleton
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0005827
name: polar microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194]
synonym: "pole-to-pole microtubule" EXACT []
is_a: GO:0005876 ! spindle microtubule
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0005828
name: kinetochore microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
synonym: "pole-to-kinetochore microtubule" EXACT []
is_a: GO:0005876 ! spindle microtubule

[Term]
id: GO:0005829
name: cytosol
namespace: cellular_component
def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
xref: NIF_Subcellular:sao101633890
xref: Wikipedia:Cytosol
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005831
name: steroid hormone aporeceptor complex
namespace: cellular_component
def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0005832
name: chaperonin-containing T-complex
namespace: cellular_component
def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]
synonym: "CCT particle" EXACT []
synonym: "TriC" EXACT []
is_a: GO:0101031 ! protein folding chaperone complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0005833
name: hemoglobin complex
namespace: cellular_component
def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732]
synonym: "haemoglobin complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0005834
name: heterotrimeric G-protein complex
namespace: cellular_component
def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]
comment: See also the molecular function term 'G protein-coupled receptor activity ; GO:0004930'.
synonym: "heterotrimeric G-protein GTPase activity" RELATED []
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW []
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1905360 ! GTPase complex
relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane

[Term]
id: GO:0005835
name: fatty acid synthase complex
namespace: cellular_component
alt_id: GO:0031373
alt_id: GO:0031374
def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pde, GOC:sgd_curators, ISBN:0716746840]
subset: goslim_pir
synonym: "cytosolic FAS complex" EXACT []
synonym: "cytosolic fatty acid synthase complex" EXACT []
synonym: "cytosolic type I FAS complex" EXACT []
synonym: "cytosolic type I fatty acid synthase complex" EXACT []
synonym: "FAS complex" EXACT []
synonym: "fatty acid synthetase complex" EXACT []
synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED []
xref: Wikipedia:Fatty_acid_synthetase_complex
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0005836
name: fatty-acyl-CoA synthase complex
namespace: cellular_component
def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [GOC:mah]
comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes.
synonym: "fatty acyl CoA synthase complex" EXACT []
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0005837
name: obsolete 26S proteasome
namespace: cellular_component
def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "26S proteasome" EXACT []
is_obsolete: true
consider: GO:0000502

[Term]
id: GO:0005838
name: proteasome regulatory particle
namespace: cellular_component
def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
synonym: "19S regulatory particle" NARROW []
synonym: "modulator complex" RELATED [CORUM:28]
synonym: "PA700 proteasome activator" NARROW []
synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0005839
name: proteasome core complex
namespace: cellular_component
alt_id: GO:0000503
def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
subset: goslim_metagenomics
synonym: "20S core complex" NARROW []
synonym: "20S proteasome" NARROW [GOC:cjk]
synonym: "macropain" EXACT []
synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0000502 ! proteasome complex

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
alt_id: GO:0033279
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046]
synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653]
synonym: "ribosomal RNA" RELATED []
xref: NIF_Subcellular:sao1429207766
xref: Wikipedia:Ribosome
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0005844
name: obsolete polysome
namespace: cellular_component
def: "OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]
comment: The reason for obsoletion is that the term is out of scope for GO.
synonym: "polyribosome" EXACT [NIF_Subcellular:sao1038025871]
xref: NIF_Subcellular:sao1038025871
xref: Wikipedia:Polysome
is_obsolete: true
consider: GO:0005840

[Term]
id: GO:0005845
name: obsolete mRNA cap binding complex
namespace: cellular_component
def: "OBSOLETE. Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0005846
name: nuclear cap binding complex
namespace: cellular_component
def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498]
comment: Note that this complex can be found in the cytoplasm as well as the nucleus.
synonym: "CBC" RELATED []
synonym: "mRNA cap binding complex" NARROW []
synonym: "NCBP-NIP1 complex" NARROW []
synonym: "nuclear CBC" EXACT []
synonym: "snRNA cap binding complex" NARROW []
is_a: GO:0034518 ! RNA cap binding complex

[Term]
id: GO:0005847
name: mRNA cleavage and polyadenylation specificity factor complex
namespace: cellular_component
def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]
synonym: "CFII complex" RELATED []
synonym: "cleavage and polyadenylylation specificity factor activity" RELATED []
synonym: "CPF complex" NARROW []
synonym: "CPSF complex" NARROW []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005848
name: mRNA cleavage stimulating factor complex
namespace: cellular_component
def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856]
synonym: "cleavage stimulation factor activity" RELATED []
synonym: "CstF complex" NARROW []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005849
name: mRNA cleavage factor complex
namespace: cellular_component
def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]
subset: goslim_pir
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0005850
name: eukaryotic translation initiation factor 2 complex
namespace: cellular_component
def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940]
synonym: "eIF-2" EXACT []
synonym: "eIF2" EXACT [GOC:mah]
xref: Wikipedia:EIF-2
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005851
name: eukaryotic translation initiation factor 2B complex
namespace: cellular_component
def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
synonym: "eIF-2B" EXACT []
synonym: "eif2B" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005852
name: eukaryotic translation initiation factor 3 complex
namespace: cellular_component
def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
synonym: "eIF-3" EXACT []
synonym: "eIF3" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005853
name: eukaryotic translation elongation factor 1 complex
namespace: cellular_component
def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005854
name: nascent polypeptide-associated complex
namespace: cellular_component
def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149]
synonym: "NAC" EXACT []
synonym: "NACA" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_yeast
xref: Wikipedia:Cytoskeleton
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0005858
name: axonemal dynein complex
namespace: cellular_component
def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]
synonym: "axonemal dynein heavy chain" NARROW []
synonym: "axonemal dynein intermediate chain" NARROW []
synonym: "axonemal dynein intermediate light chain" NARROW []
synonym: "axonemal dynein light chain" NARROW []
is_a: GO:0030286 ! dynein complex
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0005859
name: muscle myosin complex
namespace: cellular_component
def: "A filament of myosin found in a muscle cell of any type." [GOC:mah]
is_a: GO:0016460 ! myosin II complex
relationship: part_of GO:0043292 ! contractile muscle fiber

[Term]
id: GO:0005861
name: troponin complex
namespace: cellular_component
def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005862
name: muscle thin filament tropomyosin
namespace: cellular_component
def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005863
name: striated muscle myosin thick filament
namespace: cellular_component
def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194]
is_a: GO:0032982 ! myosin filament
is_a: GO:0036379 ! myofilament
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0005865
name: striated muscle thin filament
namespace: cellular_component
def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]
is_a: GO:0036379 ! myofilament
relationship: part_of GO:0015629 ! actin cytoskeleton
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0005868
name: cytoplasmic dynein complex
namespace: cellular_component
def: "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]
comment: Note that this term is labelled based on phylogenetic classification and community usage, rather than strict cellular localization. Cytoplasmic dynein complexes may contain ciliary dyneins; therefore the term is not linked to 'cytoplasm'. Cytoplasmic dynein complexes do not contain axonemal dyneins; see GO:0005858 axonemal dynein complex.
synonym: "cytoplasmic dynein heavy chain" NARROW []
synonym: "cytoplasmic dynein intermediate chain" NARROW []
synonym: "cytoplasmic dynein intermediate light chain" NARROW []
synonym: "cytoplasmic dynein light chain" NARROW []
is_a: GO:0030286 ! dynein complex

[Term]
id: GO:0005869
name: dynactin complex
namespace: cellular_component
def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]
is_a: GO:0005875 ! microtubule associated complex
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005870
name: actin capping protein of dynactin complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499]
is_a: GO:0008290 ! F-actin capping protein complex
relationship: part_of GO:0005869 ! dynactin complex

[Term]
id: GO:0005871
name: kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, PMID:32842864]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0005872
name: minus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005873
name: plus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005874
name: microtubule
namespace: cellular_component
def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
subset: goslim_metagenomics
synonym: "microtubuli" EXACT []
synonym: "microtubulus" EXACT []
synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196]
xref: NIF_Subcellular:sao1846835077
xref: Wikipedia:Microtubule
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005875
name: microtubule associated complex
namespace: cellular_component
def: "Any multimeric complex connected to a microtubule." [GOC:jl]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005876
name: spindle microtubule
namespace: cellular_component
def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005879
name: axonemal microtubule
namespace: cellular_component
def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194]
is_a: GO:0005881 ! cytoplasmic microtubule
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0005880
name: nuclear microtubule
namespace: cellular_component
def: "Any microtubule in the nucleus of a cell." [GOC:mah]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005881
name: cytoplasmic microtubule
namespace: cellular_component
def: "Any microtubule in the cytoplasm of a cell." [GOC:mah]
synonym: "non-spindle-associated astral microtubule" NARROW []
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005882
name: intermediate filament
namespace: cellular_component
def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [ISBN:0198506732, PMID:17493611, PMID:17551517, PMID:7979242]
synonym: "intermediate filament associated protein" RELATED []
synonym: "type I intermediate filament associated protein" RELATED []
synonym: "type II intermediate filament associated protein" RELATED []
xref: FMA:63851
xref: NIF_Subcellular:sao952483289
xref: Wikipedia:Intermediate_filament
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0045111 ! intermediate filament cytoskeleton

[Term]
id: GO:0005883
name: neurofilament
namespace: cellular_component
def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194]
synonym: "type IV intermediate filament" EXACT []
xref: NIF_Subcellular:sao1316272517
xref: Wikipedia:Neurofilament
is_a: GO:0005882 ! intermediate filament
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005884
name: actin filament
namespace: cellular_component
def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
synonym: "microfilament" EXACT []
xref: FMA:63850
xref: NIF_Subcellular:sao1588493326
xref: Wikipedia:Actin
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005885
name: Arp2/3 protein complex
namespace: cellular_component
def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
alt_id: GO:0005887
alt_id: GO:0005904
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "bacterial inner membrane" NARROW []
synonym: "cell membrane" EXACT []
synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645]
synonym: "cytoplasmic membrane" EXACT []
synonym: "inner endospore membrane" NARROW []
synonym: "integral component of plasma membrane" NARROW []
synonym: "integral to plasma membrane" NARROW []
synonym: "juxtamembrane" BROAD []
synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah]
synonym: "plasmalemma" EXACT []
xref: NIF_Subcellular:sao1663586795
xref: Wikipedia:Cell_membrane
is_a: GO:0016020 ! membrane
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0005888
name: obsolete proteoglycan integral to plasma membrane
namespace: cellular_component
def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product.
synonym: "proteoglycan integral to plasma membrane" EXACT []
is_obsolete: true
replaced_by: GO:0005886

[Term]
id: GO:0005889
name: potassium:proton exchanging ATPase complex
namespace: cellular_component
def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431]
synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT []
synonym: "hydrogen:potassium-exchanging ATPase complex" EXACT []
synonym: "proton pump" BROAD []
is_a: GO:0090533 ! cation-transporting ATPase complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0005890
name: sodium:potassium-exchanging ATPase complex
namespace: cellular_component
def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
synonym: "sodium pump" BROAD []
synonym: "sodium/potassium-exchanging ATPase complex" EXACT []
is_a: GO:0090533 ! cation-transporting ATPase complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0005891
name: voltage-gated calcium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]
subset: goslim_pir
synonym: "voltage gated calcium channel complex" EXACT []
synonym: "voltage-dependent calcium channel complex" EXACT []
synonym: "voltage-sensitive calcium channel complex" EXACT []
is_a: GO:0034704 ! calcium channel complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0005892
name: acetylcholine-gated channel complex
namespace: cellular_component
def: "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]
synonym: "nicotinic acetylcholine receptor" BROAD []
synonym: "nicotinic acetylcholine-gated receptor-channel complex" EXACT [GOC:bf]
is_a: GO:0034702 ! monoatomic ion channel complex
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005893
name: interleukin-2 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078]
synonym: "IL-2 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005894
name: interleukin-3 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579]
synonym: "IL-3 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005895
name: interleukin-5 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579]
synonym: "IL-5 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005896
name: interleukin-6 receptor complex
namespace: cellular_component
def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235]
synonym: "IL-6 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005897
name: interleukin-9 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536]
synonym: "IL-9 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005898
name: interleukin-13 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879]
synonym: "IL-13 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005899
name: insulin receptor complex
namespace: cellular_component
def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732]
is_a: GO:0098802 ! plasma membrane signaling receptor complex
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:0005900
name: oncostatin-M receptor complex
namespace: cellular_component
def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0005901
name: caveola
namespace: cellular_component
alt_id: GO:0016599
def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198]
synonym: "caveolae" EXACT []
synonym: "caveolar membrane" RELATED []
xref: Wikipedia:Caveolae
is_a: GO:0044853 ! plasma membrane raft

[Term]
id: GO:0005902
name: microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]
comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.
subset: goslim_pir
synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673]
xref: NIF_Subcellular:sao671419673
xref: Wikipedia:Microvillus
is_a: GO:0098858 ! actin-based cell projection

[Term]
id: GO:0005903
name: brush border
namespace: cellular_component
def: "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Brush_border
is_a: GO:0098862 ! cluster of actin-based cell projections

[Term]
id: GO:0005905
name: clathrin-coated pit
namespace: cellular_component
def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
synonym: "coated pit" EXACT [GOC:bf]
xref: NIF_Subcellular:sao1969557946
is_a: GO:0016020 ! membrane
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005906
name: obsolete clathrin adaptor
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean.
synonym: "adaptin" RELATED []
synonym: "clathrin adaptor" EXACT []
is_obsolete: true
replaced_by: GO:0030119

[Term]
id: GO:0005907
name: obsolete HA1 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
synonym: "AP1" RELATED []
synonym: "HA1 clathrin adaptor" EXACT []
is_obsolete: true
consider: GO:0030121

[Term]
id: GO:0005908
name: obsolete HA2 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
synonym: "AP2" RELATED []
synonym: "HA2 clathrin adaptor" EXACT []
is_obsolete: true
consider: GO:0030122

[Term]
id: GO:0005911
name: cell-cell junction
namespace: cellular_component
def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]
synonym: "cell-cell contact region" BROAD []
synonym: "cell-cell contact zone" BROAD []
synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368]
xref: NIF_Subcellular:sao1922892319
is_a: GO:0070161 ! anchoring junction

[Term]
id: GO:0005912
name: adherens junction
namespace: cellular_component
alt_id: GO:0005913
def: "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]
synonym: "cell-cell adherens junction" EXACT []
xref: Wikipedia:Adherens_junction
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0005914
name: spot adherens junction
namespace: cellular_component
def: "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298]
synonym: "dense plaque" BROAD []
synonym: "punctum adherens" EXACT []
is_a: GO:0005912 ! adherens junction

[Term]
id: GO:0005915
name: zonula adherens
namespace: cellular_component
def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
synonym: "adhesion belt" EXACT []
synonym: "belt desmosome" EXACT []
synonym: "intermediate junction" EXACT []
synonym: "zonula adhaerens" EXACT []
xref: NIF_Subcellular:sao1400623473
is_a: GO:0005912 ! adherens junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005916
name: fascia adherens
namespace: cellular_component
def: "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910]
xref: Wikipedia:Fascia_adherens
is_a: GO:0005911 ! cell-cell junction
relationship: part_of GO:0014704 ! intercalated disc

[Term]
id: GO:0005917
name: nephrocyte diaphragm
namespace: cellular_component
def: "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
synonym: "nephrocyte junction" RELATED [PMID:8314002]
is_a: GO:0036056 ! filtration diaphragm

[Term]
id: GO:0005918
name: septate junction
namespace: cellular_component
def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods." [ISBN:0815332181, PMID:11700298, PMID:12612641, PMID:20795303, PMID:28636800]
synonym: "septate desmosome" RELATED []
xref: NIF_Subcellular:sao427941916
is_a: GO:0070160 ! tight junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005919
name: pleated septate junction
namespace: cellular_component
def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
synonym: "pleated desmosome" RELATED []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005920
name: smooth septate junction
namespace: cellular_component
def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298]
synonym: "zonula continua" EXACT []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005921
name: gap junction
namespace: cellular_component
def: "A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181, PMID:22366062, Wikipedia:Gap_junction]
synonym: "communicating junction" EXACT []
synonym: "electrical synapse" RELATED [Wikipedia:Gap_junction]
synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124]
synonym: "gap junction macula" EXACT [NIF_Subcellular:sao700839054]
synonym: "gap junction plaque" EXACT [NIF_Subcellular:sao700839054]
synonym: "intercellular gap junction channel" RELATED []
synonym: "macula communicans" EXACT []
synonym: "zonula communicans" EXACT []
xref: NIF_Subcellular:sao118541872
xref: Wikipedia:Gap_junction
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0005922
name: connexin complex
namespace: cellular_component
def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276]
synonym: "connexon" EXACT [GOC:cjm]
synonym: "connexon complex" RELATED []
xref: NIF_Subcellular:sao445019788
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005921 ! gap junction

[Term]
id: GO:0005923
name: bicellular tight junction
namespace: cellular_component
def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
synonym: "zonula occludens" EXACT []
xref: NIF_Subcellular:sao1939999134
xref: Wikipedia:Tight_junction
is_a: GO:0070160 ! tight junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005924
name: obsolete cell-substrate adherens junction
namespace: cellular_component
def: "OBSOLETE. An adherens junction which connects a cell to the extracellular matrix." [GOC:hb]
comment: The reason for obsoletion is that, based on the most recent literature, there is no such structure in biology as 'cell-substrate adherens junction'. An 'adherens junction' is always a 'cell-cell junction' (PMIDs: 20571587, 17854762, 21422226, 28096264, 28401269, 26923917).
synonym: "hemi-adherens junction" RELATED []
is_obsolete: true

[Term]
id: GO:0005925
name: focal adhesion
namespace: cellular_component
alt_id: GO:0005926
alt_id: GO:0008357
def: "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
synonym: "adhesion plaque" RELATED [PMID:3332661]
synonym: "connecting hemi-adherens junction" EXACT []
synonym: "focal contact" EXACT []
synonym: "HAJ" EXACT []
synonym: "hemi-adherens junction" EXACT []
xref: Wikipedia:Focal_adhesion
is_a: GO:0030055 ! cell-substrate junction

[Term]
id: GO:0005927
name: muscle tendon junction
namespace: cellular_component
def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
synonym: "myotendinous junction" EXACT []
is_a: GO:0030055 ! cell-substrate junction

[Term]
id: GO:0005928
name: obsolete apical hemi-adherens junction
namespace: cellular_component
def: "OBSOLETE. A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298]
comment: The reason for obsoletion is that this term has not been used for GO annotation at all since 2001 when it was created, it has no children, it is not a part of any subset/slim.
synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah]
synonym: "apical dense plaque" EXACT []
is_obsolete: true

[Term]
id: GO:0005929
name: cilium
namespace: cellular_component
alt_id: GO:0072372
def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
synonym: "eukaryotic flagellum" EXACT []
synonym: "flagellum" RELATED []
synonym: "microtubule-based flagellum" EXACT []
synonym: "primary cilium" NARROW []
xref: FMA:67181
xref: NIF_Subcellular:sao787716553
xref: Wikipedia:Cilium
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0005930
name: axoneme
namespace: cellular_component
alt_id: GO:0035085
alt_id: GO:0035086
def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.
subset: goslim_pir
synonym: "ciliary axoneme" EXACT []
synonym: "cilium axoneme" EXACT []
synonym: "flagellar axoneme" EXACT []
synonym: "flagellum axoneme" EXACT []
xref: Wikipedia:Axoneme
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0097014 ! ciliary plasm

[Term]
id: GO:0005931
name: axonemal nexin link
namespace: cellular_component
def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [GOC:cilia, GOC:krc, ISBN:0198506732, PMID:21586547, PMID:21728999, PMID:22683354, PMID:9295136]
synonym: "axonemal interdoublet link" EXACT []
synonym: "nexin complex" BROAD []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0005933
name: cellular bud
namespace: cellular_component
def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0005934
name: cellular bud tip
namespace: cellular_component
def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0005935
name: cellular bud neck
namespace: cellular_component
def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0005936
name: obsolete shmoo
namespace: cellular_component
def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc]
comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'.
synonym: "shmoo" EXACT []
is_obsolete: true
consider: GO:0001400
consider: GO:0005937

[Term]
id: GO:0005937
name: mating projection
namespace: cellular_component
def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc]
subset: goslim_pir
synonym: "conjugation tube" NARROW []
synonym: "shmoo" NARROW []
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_yeast
synonym: "cell periphery" RELATED []
synonym: "ectoplasm" NARROW []
synonym: "peripheral cytoplasm" RELATED []
xref: Wikipedia:Cell_cortex
is_a: GO:0005737 ! cytoplasm
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0005940
name: septin ring
namespace: cellular_component
alt_id: GO:0030481
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244]
xref: Wikipedia:Septin_ring
is_a: GO:0032156 ! septin cytoskeleton
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0005941
name: obsolete unlocalized protein complex
namespace: cellular_component
def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma]
comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed.
synonym: "unlocalized protein complex" EXACT []
is_obsolete: true

[Term]
id: GO:0005942
name: phosphatidylinositol 3-kinase complex
namespace: cellular_component
def: "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488]
comment: For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
subset: goslim_pir
synonym: "1-phosphatidylinositol 3-kinase complex" EXACT []
synonym: "phosphoinositide 3-kinase complex" EXACT []
synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575]
synonym: "PI3K complex" EXACT []
synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429]
synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0019898 ! extrinsic component of membrane

[Term]
id: GO:0005943
name: phosphatidylinositol 3-kinase complex, class IA
namespace: cellular_component
alt_id: GO:0035030
def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495]
synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex" EXACT []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT []
synonym: "class IA PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class IA" EXACT []
is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I

[Term]
id: GO:0005944
name: phosphatidylinositol 3-kinase complex, class IB
namespace: cellular_component
alt_id: GO:0035031
def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495]
synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex" EXACT []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED []
synonym: "class IB PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class IB" EXACT []
is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I

[Term]
id: GO:0005945
name: 6-phosphofructokinase complex
namespace: cellular_component
def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0005946
name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
namespace: cellular_component
def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904]
comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'.
synonym: "trehalose-6-phosphate synthase complex" EXACT []
synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT []
synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT []
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005947
name: obsolete mitochondrial alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu]
comment: The reason for obsoletion is that this term is equivalent to mitochondrial oxoglutarate dehydrogenase complex.
synonym: "2-oxoglutarate dehydrogenase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045252

[Term]
id: GO:0005948
name: acetolactate synthase complex
namespace: cellular_component
def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [GOC:jl, PMID:16458324, PMID:8756689]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
synonym: "acetohydroxyacid synthase complex" EXACT []
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005949
name: obsolete aminoadipate-semialdehyde dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products.
synonym: "aminoadipate-semialdehyde dehydrogenase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0005950
name: anthranilate synthase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [PMID:4886290]
xref: MetaCyc:ANTHRANSYN-CPLX
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005951
name: carbamoyl-phosphate synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695]
comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW []
synonym: "carbamoyl phosphate synthase complex" EXACT []
synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005952
name: cAMP-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [PMID:18178622]
synonym: "3',5' cAMP-dependent protein kinase complex" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT []
synonym: "cyclic AMP-dependent protein kinase complex" EXACT []
synonym: "PKA" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0005953
name: CAAX-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874]
is_a: GO:0032476 ! polyprenyl diphosphate synthase complex
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0005954
name: calcium- and calmodulin-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [PMID:20668654]
synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT []
synonym: "CAMK2" EXACT []
synonym: "CaMKII" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0005955
name: calcineurin complex
namespace: cellular_component
def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [PMID:26794871]
synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW []
synonym: "protein phosphatase type 2B complex" EXACT []
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0005956
name: protein kinase CK2 complex
namespace: cellular_component
def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex.
synonym: "casein kinase II complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0005957
name: obsolete debranching enzyme
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex.
synonym: "debranching enzyme" EXACT []
is_obsolete: true
consider: GO:0043033

[Term]
id: GO:0005958
name: DNA-dependent protein kinase-DNA ligase 4 complex
namespace: cellular_component
alt_id: GO:0005959
def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889]
is_a: GO:0070419 ! nonhomologous end joining complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0005960
name: glycine cleavage complex
namespace: cellular_component
alt_id: GO:0005961
alt_id: GO:0070015
def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah]
subset: goslim_pir
synonym: "glycine cleavage system" EXACT []
synonym: "glycine decarboxylase complex" EXACT []
synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT []
synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED []
synonym: "glycine synthase complex" EXACT []
xref: Wikipedia:Glycine_decarboxylase_complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0005962
name: obsolete mitochondrial isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "OBSOLETE. Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu]
comment: The reason for obsoletion is that this term is unnecessarily taxon-specific.
is_obsolete: true
replaced_by: GO:0045242

[Term]
id: GO:0005963
name: magnesium-dependent protein serine/threonine phosphatase complex
namespace: cellular_component
def: "An intracellular enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [PMID:17517611, PMID:22343722]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0005964
name: phosphorylase kinase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [PMID:1370475]
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005965
name: protein farnesyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah]
is_a: GO:0032476 ! polyprenyl diphosphate synthase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005966
name: obsolete cyclic-nucleotide phosphodiesterase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-]
comment: This term was obsoleted because it described a homomer.
synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW []
is_obsolete: true

[Term]
id: GO:0005967
name: obsolete mitochondrial pyruvate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A mitochondrial complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094]
comment: This term is unnecessarily taxon-specific.
synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD []
is_obsolete: true
replaced_by: GO:0045254

[Term]
id: GO:0005968
name: Rab-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein)." [GOC:jl, PMID:11886217]
synonym: "GGTase-II complex" EXACT []
synonym: "Rab geranylgeranyltransferase complex" EXACT []
synonym: "RabGGTase complex" EXACT []
is_a: GO:0032476 ! polyprenyl diphosphate synthase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005969
name: serine-pyruvate aminotransferase complex
namespace: cellular_component
alt_id: GO:0005970
def: "A protein homodimeric complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [PMID:22751661, PMID:851432]
synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW []
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005971
name: ribonucleoside-diphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [PMID:10716984, PMID:21336276]
synonym: "ribonucleotide reductase complex" EXACT [GOC:mah]
synonym: "RNR complex" EXACT [GOC:mah]
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0005972
name: obsolete fibrinogen alpha chain
namespace: cellular_component
alt_id: GO:0008005
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "fibrinogen alpha chain" EXACT []
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005973
name: obsolete fibrinogen beta chain
namespace: cellular_component
alt_id: GO:0008006
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "fibrinogen beta chain" EXACT []
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005974
name: obsolete fibrinogen gamma chain
namespace: cellular_component
alt_id: GO:0008007
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "fibrinogen gamma chain" EXACT []
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
alt_id: GO:0044261
alt_id: GO:0044723
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "carbohydrate metabolism" EXACT []
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0005976
name: polysaccharide metabolic process
namespace: biological_process
alt_id: GO:0044263
def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684]
subset: goslim_pir
synonym: "glycan metabolic process" NARROW []
synonym: "glycan metabolism" NARROW []
synonym: "multicellular organismal polysaccharide metabolic process" NARROW []
synonym: "polysaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0005977
name: glycogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]
synonym: "glycogen metabolism" EXACT []
is_a: GO:0006112 ! energy reserve metabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0005978
name: glycogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
synonym: "glycogen anabolism" EXACT []
synonym: "glycogen biosynthesis" EXACT []
synonym: "glycogen formation" EXACT []
synonym: "glycogen synthesis" EXACT []
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0005979
name: regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
synonym: "regulation of glycogen anabolism" EXACT []
synonym: "regulation of glycogen biosynthesis" EXACT []
synonym: "regulation of glycogen formation" EXACT []
synonym: "regulation of glycogen synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0005980
name: glycogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
synonym: "glycogen breakdown" EXACT []
synonym: "glycogen catabolism" EXACT []
synonym: "glycogen degradation" EXACT []
synonym: "glycogenolysis" EXACT [GOC:sl]
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009251 ! glucan catabolic process

[Term]
id: GO:0005981
name: regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
synonym: "regulation of glycogen breakdown" EXACT []
synonym: "regulation of glycogen catabolism" EXACT []
synonym: "regulation of glycogen degradation" EXACT []
synonym: "regulation of glycogenolysis" EXACT [GOC:sl]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0005982
name: starch metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732]
synonym: "starch metabolism" EXACT []
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0005983
name: starch catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai]
synonym: "starch breakdown" EXACT []
synonym: "starch catabolism" EXACT []
synonym: "starch degradation" EXACT []
xref: MetaCyc:PWY-842
is_a: GO:0005982 ! starch metabolic process
is_a: GO:0009251 ! glucan catabolic process

[Term]
id: GO:0005984
name: disaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:0192800981]
synonym: "disaccharide metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0005985
name: sucrose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
synonym: "sucrose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005986
name: sucrose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
synonym: "sucrose anabolism" EXACT []
synonym: "sucrose biosynthesis" EXACT []
synonym: "sucrose formation" EXACT []
synonym: "sucrose synthesis" EXACT []
xref: MetaCyc:SUCSYN-PWY
is_a: GO:0005985 ! sucrose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005987
name: sucrose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
synonym: "sucrose breakdown" EXACT []
synonym: "sucrose catabolism" EXACT []
synonym: "sucrose degradation" EXACT []
is_a: GO:0005985 ! sucrose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005988
name: lactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
synonym: "lactose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005989
name: lactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
synonym: "lactose anabolism" EXACT []
synonym: "lactose biosynthesis" EXACT []
synonym: "lactose formation" EXACT []
synonym: "lactose synthesis" EXACT []
is_a: GO:0005988 ! lactose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005990
name: lactose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
synonym: "lactose breakdown" EXACT []
synonym: "lactose catabolism" EXACT []
synonym: "lactose degradation" EXACT []
is_a: GO:0005988 ! lactose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005991
name: trehalose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:jl, ISBN:0028623819]
synonym: "mycose metabolic process" EXACT []
synonym: "mycose metabolism" EXACT []
synonym: "mykose metabolic process" EXACT []
synonym: "mykose metabolism" EXACT []
synonym: "trehalose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005992
name: trehalose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:jl, ISBN:0028623819]
synonym: "mycose biosynthesis" EXACT []
synonym: "mycose biosynthetic process" EXACT []
synonym: "mykose biosynthesis" EXACT []
synonym: "mykose biosynthetic process" EXACT []
synonym: "trehalose anabolism" EXACT []
synonym: "trehalose biosynthesis" EXACT []
synonym: "trehalose formation" EXACT []
synonym: "trehalose synthesis" EXACT []
is_a: GO:0005991 ! trehalose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005993
name: trehalose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:jl, ISBN:0028623819]
synonym: "mycose catabolic process" EXACT []
synonym: "mycose catabolism" EXACT []
synonym: "mykose catabolic process" EXACT []
synonym: "mykose catabolism" EXACT []
synonym: "trehalose breakdown" EXACT []
synonym: "trehalose catabolism" EXACT []
synonym: "trehalose degradation" EXACT []
is_a: GO:0005991 ! trehalose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005994
name: melibiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684]
synonym: "melibiose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005995
name: melibiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684]
synonym: "melibiose breakdown" EXACT []
synonym: "melibiose catabolism" EXACT []
synonym: "melibiose degradation" EXACT []
is_a: GO:0005994 ! melibiose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005996
name: monosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732]
synonym: "monosaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0005997
name: xylulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
synonym: "xylulose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0005998
name: xylulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
synonym: "xylulose breakdown" EXACT []
synonym: "xylulose catabolism" EXACT []
synonym: "xylulose degradation" EXACT []
xref: MetaCyc:XYLCAT-PWY
is_a: GO:0005997 ! xylulose metabolic process
is_a: GO:0019323 ! pentose catabolic process

[Term]
id: GO:0005999
name: xylulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
synonym: "xylulose anabolism" EXACT []
synonym: "xylulose biosynthesis" EXACT []
synonym: "xylulose formation" EXACT []
synonym: "xylulose synthesis" EXACT []
is_a: GO:0005997 ! xylulose metabolic process
is_a: GO:0019322 ! pentose biosynthetic process

[Term]
id: GO:0006000
name: fructose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]
synonym: "fructose metabolism" EXACT []
xref: Wikipedia:Fructose
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006001
name: fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai]
synonym: "fructose breakdown" EXACT []
synonym: "fructose catabolism" EXACT []
synonym: "fructose degradation" EXACT []
is_a: GO:0006000 ! fructose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0006002
name: fructose 6-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732]
synonym: "fructose 6-phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0006003
name: fructose 2,6-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]
synonym: "fructose 2,6-bisphosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0006004
name: fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]
synonym: "fucose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006005
name: L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl]
synonym: "L-fucose anabolism" EXACT []
synonym: "L-fucose biosynthesis" EXACT []
synonym: "L-fucose formation" EXACT []
synonym: "L-fucose synthesis" EXACT []
is_a: GO:0042353 ! fucose biosynthetic process
is_a: GO:0042354 ! L-fucose metabolic process

[Term]
id: GO:0006006
name: glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
synonym: "cellular glucose metabolic process" EXACT [GOC:vw]
synonym: "glucose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006007
name: glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
synonym: "glucose breakdown" EXACT []
synonym: "glucose catabolism" EXACT []
synonym: "glucose degradation" EXACT []
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0006009
name: glucose 1-phosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai]
is_a: GO:0016310 ! phosphorylation
is_a: GO:0019255 ! glucose 1-phosphate metabolic process

[Term]
id: GO:0006011
name: UDP-alpha-D-glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-glucose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0006012
name: galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]
synonym: "galactose metabolism" EXACT []
xref: Wikipedia:Galactose
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006013
name: mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]
synonym: "mannose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006014
name: D-ribose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732]
synonym: "D-ribose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0006015
name: 5-phosphoribose 1-diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai]
synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT []
synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT []
synonym: "5-phosphoribose 1-diphosphate formation" EXACT []
synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT []
synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT []
synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT []
synonym: "PRPP biosynthetic process" EXACT []
is_a: GO:0046390 ! ribose phosphate biosynthetic process
is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process

[Term]
id: GO:0006016
name: 2-deoxyribose 1-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732]
synonym: "2-deoxyribose 1-phosphate anabolism" EXACT []
synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT []
synonym: "2-deoxyribose 1-phosphate formation" EXACT []
synonym: "2-deoxyribose 1-phosphate synthesis" EXACT []
is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process

[Term]
id: GO:0006017
name: deoxyribose 1,5-bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai]
synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT []
synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT []
synonym: "deoxyribose 1,5-bisphosphate formation" EXACT []
synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT []
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process
is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process

[Term]
id: GO:0006018
name: 2-deoxyribose 1-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai]
synonym: "2-deoxyribose 1-phosphate breakdown" EXACT []
synonym: "2-deoxyribose 1-phosphate catabolism" EXACT []
synonym: "2-deoxyribose 1-phosphate degradation" EXACT []
synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah]
is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process
is_a: GO:0046386 ! deoxyribose phosphate catabolic process

[Term]
id: GO:0006019
name: deoxyribose 5-phosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai]
is_a: GO:0016310 ! phosphorylation
is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process

[Term]
id: GO:0006020
name: inositol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684]
synonym: "inositol metabolism" EXACT []
synonym: "myo-inositol metabolic process" NARROW []
synonym: "myo-inositol metabolism" NARROW []
synonym: "vitamin Bh metabolic process" EXACT []
synonym: "vitamin Bh metabolism" EXACT []
xref: Wikipedia:Inositol
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:0006021
name: inositol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684]
synonym: "inositol anabolism" EXACT []
synonym: "inositol biosynthesis" EXACT []
synonym: "inositol formation" EXACT []
synonym: "inositol synthesis" EXACT []
synonym: "myo-inositol biosynthesis" NARROW []
synonym: "myo-inositol biosynthetic process" NARROW []
synonym: "vitamin Bh biosynthesis" EXACT []
synonym: "vitamin Bh biosynthetic process" EXACT []
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0006022
name: aminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0006023
name: aminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan anabolism" EXACT []
synonym: "aminoglycan biosynthesis" EXACT []
synonym: "aminoglycan formation" EXACT []
synonym: "aminoglycan synthesis" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0006024
name: glycosaminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
synonym: "glycosaminoglycan anabolism" EXACT []
synonym: "glycosaminoglycan biosynthesis" EXACT []
synonym: "glycosaminoglycan formation" EXACT []
synonym: "glycosaminoglycan synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0006025
name: obsolete galactosaminoglycan biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
comment: This term was obsoleted because it was too broad.
synonym: "galactosaminoglycan anabolism" EXACT []
synonym: "galactosaminoglycan biosynthesis" EXACT []
synonym: "galactosaminoglycan formation" EXACT []
synonym: "galactosaminoglycan synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0006026
name: aminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan breakdown" EXACT []
synonym: "aminoglycan catabolism" EXACT []
synonym: "aminoglycan degradation" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0006027
name: glycosaminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
synonym: "glycosaminoglycan breakdown" EXACT []
synonym: "glycosaminoglycan catabolism" EXACT []
synonym: "glycosaminoglycan degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0006028
name: obsolete galactosaminoglycan catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
comment: This term was obsoleted because it was too broad.
synonym: "galactosaminoglycan breakdown" EXACT []
synonym: "galactosaminoglycan catabolism" EXACT []
synonym: "galactosaminoglycan degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0006029
name: proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
synonym: "proteoglycan metabolism" EXACT []
synonym: "proteoglycan sulfate transfer" NARROW []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006030
name: chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT []
synonym: "chitin metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:0006031
name: chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT []
synonym: "chitin anabolism" EXACT []
synonym: "chitin biosynthesis" EXACT []
synonym: "chitin formation" EXACT []
synonym: "chitin synthesis" EXACT []
xref: MetaCyc:PWY-6981
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process

[Term]
id: GO:0006032
name: chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT []
synonym: "chitin breakdown" EXACT []
synonym: "chitin catabolism" EXACT []
synonym: "chitin degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process

[Term]
id: GO:0006033
name: chitin localization
namespace: biological_process
def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "chitin localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of chitin localization" EXACT []
is_a: GO:0033037 ! polysaccharide localization

[Term]
id: GO:0006034
name: obsolete cuticle chitin metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "cuticle chitin metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006030

[Term]
id: GO:0006035
name: obsolete cuticle chitin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "cuticle chitin anabolism" EXACT []
synonym: "cuticle chitin biosynthesis" EXACT []
synonym: "cuticle chitin formation" EXACT []
synonym: "cuticle chitin synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0006031

[Term]
id: GO:0006036
name: obsolete cuticle chitin catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "cuticle chitin breakdown" EXACT []
synonym: "cuticle chitin catabolism" EXACT []
synonym: "cuticle chitin degradation" EXACT []
is_obsolete: true
replaced_by: GO:0006032

[Term]
id: GO:0006037
name: obsolete cell wall chitin metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "cell wall chitin metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006030

[Term]
id: GO:0006038
name: obsolete cell wall chitin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "cell wall chitin anabolism" EXACT []
synonym: "cell wall chitin biosynthesis" EXACT []
synonym: "cell wall chitin formation" EXACT []
synonym: "cell wall chitin synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0006031

[Term]
id: GO:0006039
name: obsolete cell wall chitin catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "cell wall chitin breakdown" EXACT []
synonym: "cell wall chitin catabolism" EXACT []
synonym: "cell wall chitin degradation" EXACT []
is_obsolete: true
replaced_by: GO:0006032

[Term]
id: GO:0006040
name: amino sugar metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
synonym: "amino sugar metabolism" EXACT []
synonym: "aminosaccharide metabolic process" EXACT []
synonym: "aminosaccharide metabolism" EXACT []
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0006041
name: glucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
synonym: "chitosamine metabolic process" EXACT []
synonym: "chitosamine metabolism" EXACT []
synonym: "glucosamine metabolism" EXACT []
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:0006042
name: glucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
synonym: "chitosamine biosynthesis" EXACT []
synonym: "chitosamine biosynthetic process" EXACT []
synonym: "glucosamine anabolism" EXACT []
synonym: "glucosamine biosynthesis" EXACT []
synonym: "glucosamine formation" EXACT []
synonym: "glucosamine synthesis" EXACT []
is_a: GO:0006041 ! glucosamine metabolic process
is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process

[Term]
id: GO:0006043
name: glucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
synonym: "chitosamine catabolic process" EXACT []
synonym: "chitosamine catabolism" EXACT []
synonym: "glucosamine breakdown" EXACT []
synonym: "glucosamine catabolism" EXACT []
synonym: "glucosamine degradation" EXACT []
is_a: GO:0006041 ! glucosamine metabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process

[Term]
id: GO:0006044
name: N-acetylglucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
synonym: "N-acetylglucosamine metabolism" EXACT []
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:0006045
name: N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
synonym: "N-acetylglucosamine anabolism" EXACT []
synonym: "N-acetylglucosamine biosynthesis" EXACT []
synonym: "N-acetylglucosamine formation" EXACT []
synonym: "N-acetylglucosamine synthesis" EXACT []
is_a: GO:0006044 ! N-acetylglucosamine metabolic process
is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process

[Term]
id: GO:0006046
name: N-acetylglucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
synonym: "N-acetylglucosamine breakdown" EXACT []
synonym: "N-acetylglucosamine catabolism" EXACT []
synonym: "N-acetylglucosamine degradation" EXACT []
is_a: GO:0006044 ! N-acetylglucosamine metabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process

[Term]
id: GO:0006047
name: UDP-N-acetylglucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-N-acetylglucosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0006048
name: UDP-N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-GlcNAc biosynthesis" EXACT []
synonym: "UDP-GlcNAc biosynthetic process" EXACT []
synonym: "UDP-N-acetylglucosamine anabolism" EXACT []
synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT []
synonym: "UDP-N-acetylglucosamine formation" EXACT []
synonym: "UDP-N-acetylglucosamine synthesis" EXACT []
is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0006049
name: UDP-N-acetylglucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-N-acetylglucosamine breakdown" EXACT []
synonym: "UDP-N-acetylglucosamine catabolism" EXACT []
synonym: "UDP-N-acetylglucosamine degradation" EXACT []
is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process
is_a: GO:0009227 ! nucleotide-sugar catabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0006050
name: mannosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators]
synonym: "mannosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:0006051
name: N-acetylmannosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732]
synonym: "N-acetylmannosamine metabolism" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process

[Term]
id: GO:0006052
name: N-acetylmannosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732]
synonym: "N-acetylmannosamine anabolism" EXACT []
synonym: "N-acetylmannosamine biosynthesis" EXACT []
synonym: "N-acetylmannosamine formation" EXACT []
synonym: "N-acetylmannosamine synthesis" EXACT []
is_a: GO:0006051 ! N-acetylmannosamine metabolic process
is_a: GO:0046347 ! mannosamine biosynthetic process

[Term]
id: GO:0006053
name: N-acetylmannosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732]
synonym: "N-acetylmannosamine breakdown" EXACT []
synonym: "N-acetylmannosamine catabolism" EXACT []
synonym: "N-acetylmannosamine degradation" EXACT []
is_a: GO:0006051 ! N-acetylmannosamine metabolic process
is_a: GO:0046346 ! mannosamine catabolic process

[Term]
id: GO:0006054
name: N-acetylneuraminate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]
synonym: "N-acetylneuraminate metabolism" EXACT []
synonym: "sialic acid metabolic process" BROAD []
synonym: "sialic acid metabolism" BROAD []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0006055
name: CMP-N-acetylneuraminate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai]
synonym: "CMP-N-acetylneuraminate anabolism" EXACT []
synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT []
synonym: "CMP-N-acetylneuraminate formation" EXACT []
synonym: "CMP-N-acetylneuraminate synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process

[Term]
id: GO:0006056
name: mannoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mannoprotein, a protein that contains covalently bound mannose residues." [ISBN:0198506732]
synonym: "mannoprotein metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006057
name: mannoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a mannoprotein, a protein that contains covalently bound mannose residues." [ISBN:0198506732]
synonym: "mannoprotein anabolism" EXACT []
synonym: "mannoprotein biosynthesis" EXACT []
synonym: "mannoprotein formation" EXACT []
synonym: "mannoprotein synthesis" EXACT []
is_a: GO:0006056 ! mannoprotein metabolic process
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0006058
name: mannoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues." [ISBN:0198506732]
synonym: "mannoprotein breakdown" EXACT []
synonym: "mannoprotein catabolism" EXACT []
synonym: "mannoprotein degradation" EXACT []
is_a: GO:0006056 ! mannoprotein metabolic process
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:0006059
name: hexitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexitol metabolism" EXACT []
synonym: "sugar alcohol (hexitol) metabolic process" EXACT []
synonym: "sugar alcohol (hexitol) metabolism" EXACT []
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0006060
name: sorbitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "sorbitol metabolism" EXACT []
xref: MetaCyc:P461-PWY
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0006061
name: sorbitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "sorbitol anabolism" EXACT []
synonym: "sorbitol biosynthesis" EXACT []
synonym: "sorbitol formation" EXACT []
synonym: "sorbitol synthesis" EXACT []
is_a: GO:0006060 ! sorbitol metabolic process
is_a: GO:0019406 ! hexitol biosynthetic process

[Term]
id: GO:0006062
name: sorbitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "sorbitol breakdown" EXACT []
synonym: "sorbitol catabolism" EXACT []
synonym: "sorbitol degradation" EXACT []
xref: MetaCyc:SORBDEG-PWY
is_a: GO:0006060 ! sorbitol metabolic process
is_a: GO:0019407 ! hexitol catabolic process

[Term]
id: GO:0006063
name: uronic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732]
synonym: "uronic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006064
name: glucuronate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators]
synonym: "glucuronate breakdown" EXACT []
synonym: "glucuronate catabolism" EXACT []
synonym: "glucuronate degradation" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0006065
name: UDP-glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-glucuronate anabolism" EXACT []
synonym: "UDP-glucuronate biosynthesis" EXACT []
synonym: "UDP-glucuronate formation" EXACT []
synonym: "UDP-glucuronate synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046398 ! UDP-glucuronate metabolic process

[Term]
id: GO:0006066
name: alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_pir
synonym: "alcohol metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0006067
name: ethanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732]
synonym: "ethanol metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0006068
name: ethanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732]
synonym: "ethanol breakdown" EXACT []
synonym: "ethanol catabolism" EXACT []
synonym: "ethanol degradation" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process

[Term]
id: GO:0006069
name: obsolete ethanol oxidation
namespace: biological_process
def: "OBSOLETE. An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0006070
name: octanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators]
synonym: "octanol metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:0006071
name: glycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
synonym: "glycerol metabolism" EXACT []
xref: MetaCyc:GLYCEROLMETAB-PWY
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0006072
name: glycerol-3-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
synonym: "glycerol-3-phosphate metabolism" EXACT []
is_a: GO:0052646 ! alditol phosphate metabolic process

[Term]
id: GO:0006073
name: obsolete cellular glucan metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell." [ISBN:0198547684]
comment: This term was obsoleted because it is not different from its parent, glucan metabolic process ; GO:0044042.
synonym: "cellular glucan metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0044042

[Term]
id: GO:0006074
name: (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [ISBN:0198506732]
synonym: "1,3-beta-D-glucan metabolic process" BROAD [GOC:tb]
synonym: "1,3-beta-D-glucan metabolism" EXACT []
synonym: "1,3-beta-glucan metabolic process" BROAD [GOC:tb]
synonym: "beta-1,3 glucan metabolic process" EXACT []
synonym: "beta-1,3 glucan metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0006075
name: (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [GOC:ai]
synonym: "1,3-beta-D-glucan biosynthetic process" EXACT []
synonym: "1,3-beta-glucan anabolism" EXACT []
synonym: "1,3-beta-glucan biosynthesis" EXACT []
synonym: "1,3-beta-glucan formation" EXACT []
synonym: "1,3-beta-glucan synthesis" EXACT []
synonym: "beta-1,3 glucan anabolism" EXACT []
synonym: "beta-1,3 glucan biosynthesis" EXACT []
synonym: "beta-1,3 glucan biosynthetic process" EXACT []
synonym: "beta-1,3 glucan formation" EXACT []
synonym: "beta-1,3 glucan synthesis" EXACT []
is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0006076
name: (1->3)-beta-D-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans." [GOC:ai]
synonym: "1,3-beta-D-glucan catabolic process" EXACT []
synonym: "1,3-beta-glucan breakdown" EXACT []
synonym: "1,3-beta-glucan catabolism" EXACT []
synonym: "1,3-beta-glucan degradation" EXACT []
synonym: "beta-1,3 glucan breakdown" EXACT []
synonym: "beta-1,3 glucan catabolic process" EXACT []
synonym: "beta-1,3 glucan catabolism" EXACT []
synonym: "beta-1,3 glucan degradation" EXACT []
is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0006077
name: (1->6)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds." [ISBN:0198506732]
synonym: "1,6-beta-glucan metabolic process" EXACT []
synonym: "1,6-beta-glucan metabolism" EXACT []
synonym: "beta-1,6 glucan metabolic process" EXACT []
synonym: "beta-1,6 glucan metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0006078
name: (1->6)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:ai]
synonym: "1,6-beta-glucan anabolism" EXACT []
synonym: "1,6-beta-glucan biosynthesis" EXACT []
synonym: "1,6-beta-glucan biosynthetic process" EXACT []
synonym: "1,6-beta-glucan formation" EXACT []
synonym: "1,6-beta-glucan synthesis" EXACT []
synonym: "beta-1,6 glucan anabolism" EXACT []
synonym: "beta-1,6 glucan biosynthesis" EXACT []
synonym: "beta-1,6 glucan biosynthetic process" EXACT []
synonym: "beta-1,6 glucan formation" EXACT []
synonym: "beta-1,6 glucan synthesis" EXACT []
is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0006079
name: (1->6)-beta-D-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (1->6)-beta-D-glucans." [GOC:ai]
synonym: "1,6-beta-D-glucan breakdown" EXACT []
synonym: "1,6-beta-D-glucan catabolic process" EXACT []
synonym: "1,6-beta-D-glucan catabolism" EXACT []
synonym: "1,6-beta-D-glucan degradation" EXACT []
synonym: "beta-1,6 glucan breakdown" EXACT []
synonym: "beta-1,6 glucan catabolic process" EXACT []
synonym: "beta-1,6 glucan catabolism" EXACT []
synonym: "beta-1,6 glucan degradation" EXACT []
is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0006080
name: substituted mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators]
synonym: "substituted mannan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0006081
name: aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]
subset: goslim_pir
synonym: "aldehyde metabolism" EXACT []
synonym: "alkanal metabolic process" EXACT []
synonym: "alkanal metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006082
name: organic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
subset: goslim_pir
synonym: "organic acid metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006083
name: acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "acetate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006084
name: acetyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]
synonym: "acetyl coenzyme A metabolic process" EXACT []
synonym: "acetyl coenzyme A metabolism" EXACT []
synonym: "acetyl-CoA metabolism" EXACT []
is_a: GO:0006637 ! acyl-CoA metabolic process

[Term]
id: GO:0006085
name: acetyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]
synonym: "acetyl-CoA anabolism" EXACT []
synonym: "acetyl-CoA biosynthesis" EXACT []
synonym: "acetyl-CoA formation" EXACT []
synonym: "acetyl-CoA synthesis" EXACT []
xref: MetaCyc:Acetyl-CoA-Biosynthesis
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0006086
name: acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "acetyl-CoA anabolism from pyruvate" EXACT []
synonym: "acetyl-CoA formation from pyruvate" EXACT []
synonym: "acetyl-CoA synthesis from pyruvate" EXACT []
synonym: "pyruvate dehydrogenase pathway" EXACT []
xref: MetaCyc:PYRUVDEHYD-PWY
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0006090 ! pyruvate metabolic process

[Term]
id: GO:0006088
name: obsolete acetate to acetyl-CoA
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "acetate to acetyl-CoA" EXACT []
is_obsolete: true
consider: GO:0003987

[Term]
id: GO:0006089
name: lactate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684]
synonym: "2-hydroxypropanoate metabolic process" EXACT []
synonym: "2-hydroxypropanoate metabolism" EXACT []
synonym: "alpha-hydroxypropionate metabolic process" EXACT []
synonym: "alpha-hydroxypropionate metabolism" EXACT []
synonym: "lactate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0006090
name: pyruvate metabolic process
namespace: biological_process
alt_id: GO:0006087
def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]
subset: goslim_drosophila
synonym: "pyruvate dehydrogenase bypass" RELATED []
synonym: "pyruvate metabolism" EXACT []
xref: MetaCyc:P41-PWY
xref: Wikipedia:Pyruvic_acid
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006091
name: generation of precursor metabolites and energy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "energy pathways" BROAD []
synonym: "intermediary metabolism" RELATED [GOC:mah]
synonym: "metabolic energy generation" RELATED []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006094
name: gluconeogenesis
namespace: biological_process
def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
synonym: "glucose biosynthesis" EXACT []
synonym: "glucose biosynthetic process" EXACT []
xref: Wikipedia:Gluconeogenesis
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0006096
name: glycolytic process
namespace: biological_process
alt_id: GO:0019641
alt_id: GO:0019642
def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
synonym: "anaerobic glycolysis" RELATED []
synonym: "Embden-Meyerhof pathway" RELATED []
synonym: "Embden-Meyerhof-Parnas pathway" RELATED []
synonym: "glycolysis" RELATED [GOC:dph]
synonym: "modified Embden-Meyerhof pathway" RELATED []
xref: MetaCyc:GLYCOLYSIS-VARIANTS
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019364 ! pyridine nucleotide catabolic process
is_a: GO:0046032 ! ADP catabolic process
is_a: GO:0046034 ! ATP metabolic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0006097
name: glyoxylate cycle
namespace: biological_process
def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]
synonym: "glyoxylate bypass" EXACT []
xref: MetaCyc:GLYOXYLATE-BYPASS
xref: Wikipedia:Glyoxylate_cycle
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0046487 ! glyoxylate metabolic process

[Term]
id: GO:0006098
name: pentose-phosphate shunt
namespace: biological_process
def: "The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
synonym: "hexose monophosphate pathway" EXACT []
synonym: "pentose phosphate pathway" EXACT []
synonym: "pentose phosphate shunt" EXACT []
synonym: "pentose-phosphate pathway" EXACT []
xref: KEGG_PATHWAY:map00030
xref: MetaCyc:PENTOSE-P-PWY
xref: Wikipedia:Pentose_phosphate_pathway
is_a: GO:0006740 ! NADPH regeneration
is_a: GO:0051156 ! glucose 6-phosphate metabolic process

[Term]
id: GO:0006099
name: tricarboxylic acid cycle
namespace: biological_process
def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
synonym: "citric acid cycle" EXACT []
synonym: "Krebs cycle" EXACT []
synonym: "oxidative TCA cycle" EXACT []
synonym: "TCA cycle" EXACT []
xref: Wikipedia:Tricarboxylic_acid_cycle
is_a: GO:0044238 ! primary metabolic process
relationship: part_of GO:0009060 ! aerobic respiration

[Term]
id: GO:0006100
name: obsolete tricarboxylic acid cycle intermediate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai]
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
synonym: "citric acid cycle intermediate metabolic process" EXACT []
synonym: "citric acid cycle intermediate metabolism" EXACT []
synonym: "Krebs cycle intermediate metabolic process" EXACT []
synonym: "Krebs cycle intermediate metabolism" EXACT []
synonym: "TCA intermediate metabolic process" EXACT []
synonym: "TCA intermediate metabolism" EXACT []
synonym: "tricarboxylic acid cycle intermediate metabolic process" EXACT []
synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT []
is_obsolete: true
consider: GO:0006099
consider: GO:0006101
consider: GO:0006103
consider: GO:0006104
consider: GO:0006105
consider: GO:0006106
consider: GO:0006107
consider: GO:0006108

[Term]
id: GO:0006101
name: citrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
synonym: "citrate metabolism" EXACT []
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0006102
name: isocitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]
synonym: "isocitrate metabolism" EXACT []
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0006103
name: 2-oxoglutarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732]
synonym: "2-ketoglutarate metabolic process" EXACT []
synonym: "2-ketoglutarate metabolism" EXACT []
synonym: "2-oxoglutarate metabolism" EXACT []
synonym: "alpha-ketoglutarate metabolic process" EXACT []
synonym: "alpha-ketoglutarate metabolism" EXACT []
synonym: "alpha-oxoglutarate metabolic process" EXACT []
synonym: "alpha-oxoglutarate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006104
name: succinyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai]
synonym: "succinyl-CoA metabolism" EXACT []
is_a: GO:0006637 ! acyl-CoA metabolic process

[Term]
id: GO:0006105
name: succinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732]
synonym: "succinate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006106
name: fumarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732]
synonym: "fumarate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006107
name: oxaloacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732]
synonym: "oxaloacetate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006108
name: malate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
synonym: "malate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006109
name: regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
synonym: "regulation of carbohydrate metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0006110
name: regulation of glycolytic process
namespace: biological_process
alt_id: GO:0090525
def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators]
synonym: "regulation of glycolysis involved in cellular glucose homeostasis" EXACT []
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
relationship: regulates GO:0006096 ! glycolytic process

[Term]
id: GO:0006111
name: regulation of gluconeogenesis
namespace: biological_process
alt_id: GO:0090526
def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators]
synonym: "regulation of gluconeogenesis involved in cellular glucose homeostasis" RELATED []
synonym: "regulation of glucose biosynthesis" BROAD []
synonym: "regulation of glucose biosynthetic process" BROAD []
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0006112
name: energy reserve metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah]
subset: goslim_pir
synonym: "energy reserve metabolism" EXACT []
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0006113
name: fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP)." [GOC:curators, ISBN:0201090910, MetaCyc:Fermentation]
subset: goslim_pir
xref: MetaCyc:Fermentation
xref: Wikipedia:Fermentation_(biochemistry)
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0006114
name: glycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
synonym: "glycerol anabolism" EXACT []
synonym: "glycerol biosynthesis" EXACT []
synonym: "glycerol formation" EXACT []
synonym: "glycerol synthesis" EXACT []
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0019401 ! alditol biosynthetic process

[Term]
id: GO:0006115
name: ethanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732]
synonym: "ethanol anabolism" EXACT []
synonym: "ethanol biosynthesis" EXACT []
synonym: "ethanol formation" EXACT []
synonym: "ethanol synthesis" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process

[Term]
id: GO:0006116
name: NADH oxidation
namespace: biological_process
def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]
synonym: "NAD (reduced) dehydrogenation" EXACT []
synonym: "NAD (reduced) oxidation" EXACT []
synonym: "NADH dehydrogenation" EXACT []
synonym: "reduced NAD dehydrogenation" EXACT []
synonym: "reduced NAD oxidation" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT []
is_a: GO:0006734 ! NADH metabolic process

[Term]
id: GO:0006117
name: acetaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:go_curators]
synonym: "acetaldehyde metabolism" EXACT []
synonym: "ethanal metabolic process" EXACT []
synonym: "ethanal metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process

[Term]
id: GO:0006118
name: obsolete electron transport
namespace: biological_process
def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [GOC:curators]
comment: This term was made obsolete because it describes a molecular function.
synonym: "6-phosphofructokinase reduction" RELATED []
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "dihydrolipoamide reduction" RELATED []
synonym: "dihydrolipoylprotein reduction" RELATED []
synonym: "dihydropteridine reduction" RELATED []
synonym: "electron transfer" EXACT []
synonym: "electron transport" EXACT []
synonym: "other pathways of electron transport" RELATED []
synonym: "oxidized glutathione reduction" RELATED []
synonym: "protein-disulfide reduction" RELATED []
is_obsolete: true
consider: GO:0016491
consider: GO:0022904

[Term]
id: GO:0006119
name: oxidative phosphorylation
namespace: biological_process
def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309]
subset: goslim_pir
synonym: "respiratory-chain phosphorylation" EXACT []
xref: Wikipedia:Oxidative_phosphorylation
is_a: GO:0009060 ! aerobic respiration

[Term]
id: GO:0006120
name: mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]
synonym: "complex I (NADH to ubiquinone)" RELATED []
synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT []
is_a: GO:0019646 ! aerobic electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006121
name: mitochondrial electron transport, succinate to ubiquinone
namespace: biological_process
def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363]
synonym: "complex II (succinate to ubiquinone)" RELATED []
synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT []
synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT []
is_a: GO:0019646 ! aerobic electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006122
name: mitochondrial electron transport, ubiquinol to cytochrome c
namespace: biological_process
def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]
synonym: "complex III (ubiquinone to cytochrome c)" RELATED []
is_a: GO:0019646 ! aerobic electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006123
name: mitochondrial electron transport, cytochrome c to oxygen
namespace: biological_process
def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]
synonym: "complex IV (reduction of O2)" RELATED []
is_a: GO:0019646 ! aerobic electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006124
name: ferredoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732]
synonym: "ferredoxin metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0006125
name: obsolete thioredoxin pathway
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_electron_transport]
comment: This term was made obsolete because it is not clear what it is intended to represent.
synonym: "thioredoxin pathway" EXACT []
synonym: "thioredoxin reduction" NARROW []
is_obsolete: true
consider: GO:0045454

[Term]
id: GO:0006126
name: obsolete other pathways of electron transport
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other pathways of electron transport" EXACT []
is_obsolete: true
replaced_by: GO:0022900

[Term]
id: GO:0006127
name: glycerophosphate shuttle
namespace: biological_process
def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716720094, PMID:16368075]
xref: MetaCyc:PWY-6118
is_a: GO:0006116 ! NADH oxidation
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:1901661 ! quinone metabolic process
relationship: part_of GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0006128
name: obsolete oxidized glutathione reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway.
synonym: "oxidized glutathione reduction" EXACT []
is_obsolete: true
consider: GO:0004362
consider: GO:0006749
consider: GO:0022900

[Term]
id: GO:0006129
name: obsolete protein-disulfide reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "protein-disulfide reduction" EXACT []
synonym: "protein-disulphide reduction" EXACT []
is_obsolete: true
consider: GO:0019153
consider: GO:0022900

[Term]
id: GO:0006130
name: obsolete 6-phosphofructokinase reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function.
synonym: "6-phosphofructokinase reduction" EXACT []
is_obsolete: true
consider: GO:0003872
consider: GO:0022900

[Term]
id: GO:0006131
name: obsolete dihydrolipoamide reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrolipoamide reduction" EXACT []
is_obsolete: true
consider: GO:0004148
consider: GO:0022900
consider: GO:0051068

[Term]
id: GO:0006132
name: obsolete dihydrolipoylprotein reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrolipoylprotein reduction" EXACT []
is_obsolete: true
consider: GO:0004148
consider: GO:0022900

[Term]
id: GO:0006133
name: obsolete 5,10-methylenetetrahydrofolate oxidation
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_electron_transport]
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
synonym: "5,10-methylenetetrahydrofolate oxidation" EXACT []
is_obsolete: true
consider: GO:0004487
consider: GO:0004488
consider: GO:0004489
consider: GO:0033738

[Term]
id: GO:0006134
name: obsolete dihydrobiopterin reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrobiopterin reduction" EXACT []
is_obsolete: true
consider: GO:0022900
consider: GO:0047040
consider: GO:0051066

[Term]
id: GO:0006135
name: obsolete dihydropteridine reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydropteridine reduction" EXACT []
is_obsolete: true
consider: GO:0004155
consider: GO:0022900
consider: GO:0051067

[Term]
id: GO:0006139
name: nucleobase-containing compound metabolic process
namespace: biological_process
alt_id: GO:0055134
def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
subset: goslim_pir
subset: goslim_plant
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0006140
name: regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
synonym: "regulation of nucleotide metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0006141
name: regulation of purine nucleobase metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators]
synonym: "regulation of purine base metabolic process" EXACT [GOC:go_curators]
synonym: "regulation of purine base metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0006142
name: regulation of pyrimidine nucleobase metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators]
synonym: "regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "regulation of pyrimidine base metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0006143
name: obsolete purine metabolic process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "purine metabolic process" EXACT []
is_obsolete: true
consider: GO:0006144
consider: GO:0006163
consider: GO:0042278

[Term]
id: GO:0006144
name: purine nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]
synonym: "purine base metabolic process" EXACT [GOC:go_curators]
synonym: "purine base metabolism" EXACT []
synonym: "purine metabolic process" NARROW []
synonym: "purine metabolism" NARROW []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0006145
name: purine nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]
synonym: "purine base breakdown" EXACT []
synonym: "purine base catabolic process" EXACT [GOC:go_curators]
synonym: "purine base catabolism" EXACT []
synonym: "purine base degradation" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process
is_a: GO:0046113 ! nucleobase catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0006146
name: adenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732]
synonym: "adenine breakdown" EXACT []
synonym: "adenine catabolism" EXACT []
synonym: "adenine degradation" EXACT []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046083 ! adenine metabolic process

[Term]
id: GO:0006147
name: guanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
synonym: "guanine breakdown" EXACT []
synonym: "guanine catabolism" EXACT []
synonym: "guanine degradation" EXACT []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0006148
name: inosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
synonym: "inosine breakdown" EXACT []
synonym: "inosine catabolism" EXACT []
synonym: "inosine degradation" EXACT []
is_a: GO:0046102 ! inosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0006149
name: deoxyinosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
synonym: "deoxyinosine breakdown" EXACT []
synonym: "deoxyinosine catabolism" EXACT []
synonym: "deoxyinosine degradation" EXACT []
is_a: GO:0046094 ! deoxyinosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006152
name: purine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]
synonym: "purine nucleoside breakdown" EXACT []
synonym: "purine nucleoside catabolism" EXACT []
synonym: "purine nucleoside degradation" EXACT []
is_a: GO:0009164 ! nucleoside catabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0006153
name: obsolete purine nucleosidase reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "purine nucleosidase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0008477

[Term]
id: GO:0006154
name: adenosine catabolic process
namespace: biological_process
alt_id: GO:0006156
def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
synonym: "adenosine breakdown" EXACT []
synonym: "adenosine catabolism" EXACT []
synonym: "adenosine degradation" EXACT []
synonym: "adenosine phosphorolysis" RELATED []
is_a: GO:0046085 ! adenosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0006155
name: obsolete adenosine deaminase reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "adenosine deaminase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004000

[Term]
id: GO:0006157
name: deoxyadenosine catabolic process
namespace: biological_process
alt_id: GO:0006159
def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxyadenosine breakdown" EXACT []
synonym: "deoxyadenosine catabolism" EXACT []
synonym: "deoxyadenosine degradation" EXACT []
synonym: "deoxyadenosine phosphorolysis" RELATED []
is_a: GO:0046090 ! deoxyadenosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006158
name: obsolete deoxyadenosine deaminase reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "deoxyadenosine deaminase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0046936

[Term]
id: GO:0006161
name: deoxyguanosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl]
synonym: "deoxyguanosine breakdown" EXACT []
synonym: "deoxyguanosine catabolism" EXACT []
synonym: "deoxyguanosine degradation" EXACT []
is_a: GO:0042453 ! deoxyguanosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006162
name: obsolete purine/pyrimidine nucleoside diphosphate reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "purine/pyrimidine nucleoside diphosphate reduction" EXACT []
is_obsolete: true
consider: GO:0004748

[Term]
id: GO:0006163
name: purine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine metabolic process" NARROW []
synonym: "purine metabolism" NARROW []
synonym: "purine nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0006164
name: purine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleotide anabolism" EXACT []
synonym: "purine nucleotide biosynthesis" EXACT []
synonym: "purine nucleotide formation" EXACT []
synonym: "purine nucleotide synthesis" EXACT []
xref: MetaCyc:DENOVOPURINE2-PWY
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0006165
name: obsolete nucleoside diphosphate phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0006166
name: purine ribonucleoside salvage
namespace: biological_process
def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
xref: MetaCyc:P121-PWY
is_a: GO:0043101 ! purine-containing compound salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0006167
name: AMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732]
synonym: "AMP anabolism" EXACT []
synonym: "AMP biosynthesis" EXACT []
synonym: "AMP formation" EXACT []
synonym: "AMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046033 ! AMP metabolic process

[Term]
id: GO:0006168
name: adenine salvage
namespace: biological_process
def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl]
synonym: "adenine salvage pathway" EXACT []
synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD []
is_a: GO:0043096 ! purine nucleobase salvage
is_a: GO:0046084 ! adenine biosynthetic process

[Term]
id: GO:0006169
name: adenosine salvage
namespace: biological_process
def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046086 ! adenosine biosynthetic process

[Term]
id: GO:0006170
name: dAMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732]
synonym: "dAMP anabolism" EXACT []
synonym: "dAMP biosynthesis" EXACT []
synonym: "dAMP formation" EXACT []
synonym: "dAMP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046053 ! dAMP metabolic process

[Term]
id: GO:0006171
name: cAMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
synonym: "3',5' cAMP biosynthesis" EXACT []
synonym: "3',5' cAMP biosynthetic process" EXACT []
synonym: "3',5'-cAMP biosynthesis" EXACT []
synonym: "3',5'-cAMP biosynthetic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "cAMP anabolism" EXACT []
synonym: "cAMP biosynthesis" EXACT []
synonym: "cAMP formation" EXACT []
synonym: "cAMP synthesis" EXACT []
synonym: "cyclic AMP biosynthesis" EXACT []
synonym: "cyclic AMP biosynthetic process" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009190 ! cyclic nucleotide biosynthetic process
is_a: GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0006172
name: ADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai]
synonym: "ADP anabolism" EXACT []
synonym: "ADP biosynthesis" EXACT []
synonym: "ADP formation" EXACT []
synonym: "ADP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0006173
name: dADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732]
synonym: "dADP anabolism" EXACT []
synonym: "dADP biosynthesis" EXACT []
synonym: "dADP formation" EXACT []
synonym: "dADP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0006174
name: obsolete dADP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0006175
name: dATP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732]
synonym: "dATP anabolism" EXACT []
synonym: "dATP biosynthesis" EXACT []
synonym: "dATP formation" EXACT []
synonym: "dATP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046060 ! dATP metabolic process

[Term]
id: GO:0006176
name: dATP biosynthetic process from ADP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732]
synonym: "dATP anabolism from ADP" EXACT []
synonym: "dATP formation from ADP" EXACT []
synonym: "dATP synthesis from ADP" EXACT []
is_a: GO:0006175 ! dATP biosynthetic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0006177
name: GMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]
synonym: "GMP anabolism" EXACT []
synonym: "GMP biosynthesis" EXACT []
synonym: "GMP formation" EXACT []
synonym: "GMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046037 ! GMP metabolic process

[Term]
id: GO:0006178
name: guanine salvage
namespace: biological_process
def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl]
synonym: "guanine, xanthine and their nucleoside salvage" BROAD []
is_a: GO:0043096 ! purine nucleobase salvage
is_a: GO:0046099 ! guanine biosynthetic process

[Term]
id: GO:0006179
name: guanosine salvage
namespace: biological_process
def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
synonym: "guanine, xanthine and their nucleoside salvage" BROAD []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046114 ! guanosine biosynthetic process

[Term]
id: GO:0006180
name: deoxyguanosine salvage
namespace: biological_process
def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl]
is_a: GO:0042452 ! deoxyguanosine biosynthetic process
is_a: GO:0043098 ! purine deoxyribonucleoside salvage

[Term]
id: GO:0006181
name: dGMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732]
synonym: "dGMP anabolism" EXACT []
synonym: "dGMP biosynthesis" EXACT []
synonym: "dGMP formation" EXACT []
synonym: "dGMP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046054 ! dGMP metabolic process

[Term]
id: GO:0006182
name: cGMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]
synonym: "cGMP anabolism" EXACT []
synonym: "cGMP biosynthesis" EXACT []
synonym: "cGMP formation" EXACT []
synonym: "cGMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009190 ! cyclic nucleotide biosynthetic process
is_a: GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0006183
name: GTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
synonym: "GTP anabolism" EXACT []
synonym: "GTP biosynthesis" EXACT []
synonym: "GTP formation" EXACT []
synonym: "GTP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046039 ! GTP metabolic process

[Term]
id: GO:0006184
name: obsolete GTP catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "GTP breakdown" EXACT []
synonym: "GTP catabolism" EXACT []
synonym: "GTP degradation" EXACT []
synonym: "GTP hydrolysis" NARROW []
is_obsolete: true
consider: GO:0003924

[Term]
id: GO:0006185
name: dGDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732]
synonym: "dGDP anabolism" EXACT []
synonym: "dGDP biosynthesis" EXACT []
synonym: "dGDP formation" EXACT []
synonym: "dGDP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0006186
name: obsolete dGDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0006187
name: dGTP biosynthetic process from dGDP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732]
synonym: "dGTP anabolism from dGDP" EXACT []
synonym: "dGTP formation from dGDP" EXACT []
synonym: "dGTP synthesis from dGDP" EXACT []
is_a: GO:0046066 ! dGDP metabolic process
is_a: GO:0046071 ! dGTP biosynthetic process

[Term]
id: GO:0006188
name: IMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732]
synonym: "IMP anabolism" EXACT []
synonym: "IMP biosynthesis" EXACT []
synonym: "IMP formation" EXACT []
synonym: "IMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006189
name: 'de novo' IMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]
synonym: "'de novo' IMP anabolism" EXACT []
synonym: "'de novo' IMP biosynthesis" EXACT []
synonym: "'de novo' IMP formation" EXACT []
synonym: "'de novo' IMP synthesis" EXACT []
synonym: "'de novo' purine biosynthesis" BROAD []
synonym: "'de novo' purine biosynthetic process" BROAD []
is_a: GO:0006188 ! IMP biosynthetic process

[Term]
id: GO:0006190
name: inosine salvage
namespace: biological_process
def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED []
synonym: "guanine, xanthine and their nucleoside salvage" RELATED []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046103 ! inosine biosynthetic process

[Term]
id: GO:0006191
name: deoxyinosine salvage
namespace: biological_process
def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl]
is_a: GO:0043098 ! purine deoxyribonucleoside salvage
is_a: GO:0046095 ! deoxyinosine biosynthetic process

[Term]
id: GO:0006192
name: obsolete IDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0006193
name: ITP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732]
synonym: "ITP breakdown" EXACT []
synonym: "ITP catabolism" EXACT []
synonym: "ITP degradation" EXACT []
synonym: "ITP hydrolysis" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process
is_a: GO:0046041 ! ITP metabolic process

[Term]
id: GO:0006194
name: obsolete dIDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0006195
name: purine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleotide breakdown" EXACT []
synonym: "purine nucleotide catabolism" EXACT []
synonym: "purine nucleotide degradation" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0006196
name: AMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732]
synonym: "AMP breakdown" EXACT []
synonym: "AMP catabolism" EXACT []
synonym: "AMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046033 ! AMP metabolic process

[Term]
id: GO:0006197
name: obsolete adenylate deaminase reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "adenylate deaminase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0003876

[Term]
id: GO:0006198
name: cAMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
synonym: "3',5' cAMP catabolic process" EXACT []
synonym: "3',5' cAMP catabolism" EXACT []
synonym: "3',5'-cAMP catabolic process" EXACT []
synonym: "3',5'-cAMP catabolism" EXACT []
synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "cAMP breakdown" EXACT []
synonym: "cAMP catabolism" EXACT []
synonym: "cAMP degradation" EXACT []
synonym: "cyclic AMP catabolic process" EXACT []
synonym: "cyclic AMP catabolism" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009214 ! cyclic nucleotide catabolic process
is_a: GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0006199
name: obsolete ADP reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "ADP reduction" EXACT []
is_obsolete: true
consider: GO:0051061

[Term]
id: GO:0006200
name: obsolete ATP catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "ATP breakdown" EXACT []
synonym: "ATP catabolism" EXACT []
synonym: "ATP degradation" EXACT []
synonym: "ATP hydrolysis" NARROW []
xref: Wikipedia:ATP_hydrolysis
is_obsolete: true
consider: GO:0016887

[Term]
id: GO:0006201
name: GMP catabolic process to IMP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732]
synonym: "GMP breakdown to IMP" EXACT []
synonym: "GMP degradation to IMP" EXACT []
is_a: GO:0046038 ! GMP catabolic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006202
name: GMP catabolic process to guanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732]
synonym: "GMP breakdown to guanine" EXACT []
synonym: "GMP degradation to guanine" EXACT []
is_a: GO:0046038 ! GMP catabolic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0006203
name: dGTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732]
synonym: "dGTP breakdown" EXACT []
synonym: "dGTP catabolism" EXACT []
synonym: "dGTP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046070 ! dGTP metabolic process

[Term]
id: GO:0006204
name: IMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732]
synonym: "IMP breakdown" EXACT []
synonym: "IMP catabolism" EXACT []
synonym: "IMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006205
name: obsolete pyrimidine metabolic process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "pyrimidine metabolic process" EXACT []
is_obsolete: true
consider: GO:0006206
consider: GO:0006213
consider: GO:0006220

[Term]
id: GO:0006206
name: pyrimidine nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]
synonym: "pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "pyrimidine base metabolism" EXACT []
synonym: "pyrimidine metabolic process" RELATED []
synonym: "pyrimidine metabolism" RELATED []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0006207
name: 'de novo' pyrimidine nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
synonym: "'de novo' pyrimidine base anabolism" EXACT []
synonym: "'de novo' pyrimidine base biosynthesis" EXACT []
synonym: "'de novo' pyrimidine base biosynthetic process" EXACT [GOC:go_curators]
synonym: "'de novo' pyrimidine base formation" EXACT []
synonym: "'de novo' pyrimidine base synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process

[Term]
id: GO:0006208
name: pyrimidine nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]
synonym: "pyrimidine base breakdown" EXACT []
synonym: "pyrimidine base catabolic process" EXACT [GOC:go_curators]
synonym: "pyrimidine base catabolism" EXACT []
synonym: "pyrimidine base degradation" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process
is_a: GO:0046113 ! nucleobase catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0006209
name: cytosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators]
synonym: "cytosine breakdown" EXACT []
synonym: "cytosine catabolism" EXACT []
synonym: "cytosine degradation" EXACT []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019858 ! cytosine metabolic process

[Term]
id: GO:0006210
name: thymine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
synonym: "thymine breakdown" EXACT []
synonym: "thymine catabolism" EXACT []
synonym: "thymine degradation" EXACT []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019859 ! thymine metabolic process

[Term]
id: GO:0006211
name: obsolete 5-methylcytosine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators]
comment: This term was obsoleted because it it redundant with chromosomal 5-methylcytosine DNA demethylation pathway ; GO:0141166 or its children.
synonym: "5-methylcytosine breakdown" EXACT []
synonym: "5-methylcytosine catabolism" EXACT []
synonym: "5-methylcytosine degradation" EXACT []
is_obsolete: true
consider: GO:0141166

[Term]
id: GO:0006212
name: uracil catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
synonym: "uracil breakdown" EXACT []
synonym: "uracil catabolism" EXACT []
synonym: "uracil degradation" EXACT []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019860 ! uracil metabolic process

[Term]
id: GO:0006213
name: pyrimidine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
synonym: "pyrimidine metabolic process" BROAD []
synonym: "pyrimidine metabolism" BROAD []
synonym: "pyrimidine nucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0006214
name: thymidine catabolic process
namespace: biological_process
alt_id: GO:0006215
def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
synonym: "deoxyribosylthymine catabolic process" EXACT []
synonym: "deoxyribosylthymine catabolism" EXACT []
synonym: "thymidine breakdown" EXACT []
synonym: "thymidine catabolism" EXACT []
synonym: "thymidine degradation" EXACT []
is_a: GO:0046104 ! thymidine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006216
name: cytidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai]
synonym: "cytidine breakdown" EXACT []
synonym: "cytidine catabolism" EXACT []
synonym: "cytidine degradation" EXACT []
is_a: GO:0046087 ! cytidine metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006217
name: deoxycytidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxycytidine breakdown" EXACT []
synonym: "deoxycytidine catabolism" EXACT []
synonym: "deoxycytidine degradation" EXACT []
is_a: GO:0046092 ! deoxycytidine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006218
name: uridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
synonym: "uridine breakdown" EXACT []
synonym: "uridine catabolism" EXACT []
synonym: "uridine degradation" EXACT []
is_a: GO:0046108 ! uridine metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006219
name: deoxyuridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxyuridine breakdown" EXACT []
synonym: "deoxyuridine catabolism" EXACT []
synonym: "deoxyuridine degradation" EXACT []
is_a: GO:0046096 ! deoxyuridine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006220
name: pyrimidine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine metabolic process" BROAD []
synonym: "pyrimidine metabolism" BROAD []
synonym: "pyrimidine nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0006221
name: pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleotide anabolism" EXACT []
synonym: "pyrimidine nucleotide biosynthesis" EXACT []
synonym: "pyrimidine nucleotide formation" EXACT []
synonym: "pyrimidine nucleotide synthesis" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0006222
name: UMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]
synonym: "UMP anabolism" EXACT []
synonym: "UMP biosynthesis" EXACT []
synonym: "UMP formation" EXACT []
synonym: "UMP synthesis" EXACT []
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046049 ! UMP metabolic process

[Term]
id: GO:0006223
name: uracil salvage
namespace: biological_process
def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl]
is_a: GO:0043100 ! pyrimidine nucleobase salvage
is_a: GO:0046107 ! uracil biosynthetic process

[Term]
id: GO:0006224
name: obsolete uridine kinase reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "uridine kinase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004849

[Term]
id: GO:0006225
name: UDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732]
synonym: "UDP anabolism" EXACT []
synonym: "UDP biosynthesis" EXACT []
synonym: "UDP formation" EXACT []
synonym: "UDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046048 ! UDP metabolic process

[Term]
id: GO:0006226
name: dUMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732]
synonym: "dUMP anabolism" EXACT []
synonym: "dUMP biosynthesis" EXACT []
synonym: "dUMP formation" EXACT []
synonym: "dUMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046078 ! dUMP metabolic process

[Term]
id: GO:0006227
name: dUDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732]
synonym: "dUDP anabolism" EXACT []
synonym: "dUDP biosynthesis" EXACT []
synonym: "dUDP formation" EXACT []
synonym: "dUDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046077 ! dUDP metabolic process

[Term]
id: GO:0006228
name: UTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
synonym: "UTP anabolism" EXACT []
synonym: "UTP biosynthesis" EXACT []
synonym: "UTP formation" EXACT []
synonym: "UTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046051 ! UTP metabolic process

[Term]
id: GO:0006229
name: dUTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732]
synonym: "dUTP anabolism" EXACT []
synonym: "dUTP biosynthesis" EXACT []
synonym: "dUTP formation" EXACT []
synonym: "dUTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046080 ! dUTP metabolic process

[Term]
id: GO:0006230
name: TMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732]
synonym: "TMP anabolism" EXACT []
synonym: "TMP biosynthesis" EXACT []
synonym: "TMP formation" EXACT []
synonym: "TMP synthesis" EXACT []
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046044 ! TMP metabolic process

[Term]
id: GO:0006231
name: dTMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732]
synonym: "dTMP anabolism" EXACT []
synonym: "dTMP biosynthesis" EXACT []
synonym: "dTMP formation" EXACT []
synonym: "dTMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046073 ! dTMP metabolic process

[Term]
id: GO:0006232
name: TDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732]
synonym: "TDP anabolism" EXACT []
synonym: "TDP biosynthesis" EXACT []
synonym: "TDP formation" EXACT []
synonym: "TDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046043 ! TDP metabolic process

[Term]
id: GO:0006233
name: dTDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732]
synonym: "dTDP anabolism" EXACT []
synonym: "dTDP biosynthesis" EXACT []
synonym: "dTDP formation" EXACT []
synonym: "dTDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046072 ! dTDP metabolic process

[Term]
id: GO:0006234
name: TTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732]
synonym: "TTP anabolism" EXACT []
synonym: "TTP biosynthesis" EXACT []
synonym: "TTP formation" EXACT []
synonym: "TTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046046 ! TTP metabolic process

[Term]
id: GO:0006235
name: dTTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732]
synonym: "dTTP anabolism" EXACT []
synonym: "dTTP biosynthesis" EXACT []
synonym: "dTTP formation" EXACT []
synonym: "dTTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046075 ! dTTP metabolic process

[Term]
id: GO:0006236
name: cytidine salvage
namespace: biological_process
def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
is_a: GO:0043097 ! pyrimidine nucleoside salvage
is_a: GO:0046088 ! cytidine biosynthetic process

[Term]
id: GO:0006237
name: deoxycytidine salvage
namespace: biological_process
def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl]
is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage
is_a: GO:0046093 ! deoxycytidine biosynthetic process

[Term]
id: GO:0006238
name: CMP salvage
namespace: biological_process
def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl]
synonym: "cytidine monophosphate salvage" EXACT []
is_a: GO:0009224 ! CMP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage

[Term]
id: GO:0006239
name: dCMP salvage
namespace: biological_process
def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl]
synonym: "deoxycytidine monophosphate salvage" EXACT []
is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage
is_a: GO:0046064 ! dCMP biosynthetic process

[Term]
id: GO:0006240
name: dCDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732]
synonym: "dCDP anabolism" EXACT []
synonym: "dCDP biosynthesis" EXACT []
synonym: "dCDP formation" EXACT []
synonym: "dCDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046062 ! dCDP metabolic process

[Term]
id: GO:0006241
name: CTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
synonym: "CTP anabolism" EXACT []
synonym: "CTP biosynthesis" EXACT []
synonym: "CTP formation" EXACT []
synonym: "CTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046036 ! CTP metabolic process

[Term]
id: GO:0006242
name: dCTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732]
synonym: "dCTP anabolism" EXACT []
synonym: "dCTP biosynthesis" EXACT []
synonym: "dCTP formation" EXACT []
synonym: "dCTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046065 ! dCTP metabolic process

[Term]
id: GO:0006244
name: pyrimidine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleotide breakdown" EXACT []
synonym: "pyrimidine nucleotide catabolism" EXACT []
synonym: "pyrimidine nucleotide degradation" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0006245
name: TDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732]
synonym: "TDP breakdown" EXACT []
synonym: "TDP catabolism" EXACT []
synonym: "TDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046043 ! TDP metabolic process

[Term]
id: GO:0006246
name: dTDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732]
synonym: "dTDP breakdown" EXACT []
synonym: "dTDP catabolism" EXACT []
synonym: "dTDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046072 ! dTDP metabolic process

[Term]
id: GO:0006247
name: obsolete TTP reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "TTP reduction" EXACT []
is_obsolete: true
consider: GO:0008998

[Term]
id: GO:0006248
name: CMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732]
synonym: "CMP breakdown" EXACT []
synonym: "CMP catabolism" EXACT []
synonym: "CMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046035 ! CMP metabolic process

[Term]
id: GO:0006249
name: dCMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732]
synonym: "dCMP breakdown" EXACT []
synonym: "dCMP catabolism" EXACT []
synonym: "dCMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046063 ! dCMP metabolic process

[Term]
id: GO:0006250
name: obsolete CDP reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "CDP reduction" EXACT []
is_obsolete: true
consider: GO:0051063

[Term]
id: GO:0006251
name: dCDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732]
synonym: "dCDP breakdown" EXACT []
synonym: "dCDP catabolism" EXACT []
synonym: "dCDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046062 ! dCDP metabolic process

[Term]
id: GO:0006252
name: obsolete CTP reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "CTP reduction" EXACT []
is_obsolete: true
consider: GO:0008998

[Term]
id: GO:0006253
name: dCTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732]
synonym: "dCTP breakdown" EXACT []
synonym: "dCTP catabolism" EXACT []
synonym: "dCTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046065 ! dCTP metabolic process

[Term]
id: GO:0006254
name: CTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
synonym: "CTP breakdown" EXACT []
synonym: "CTP catabolism" EXACT []
synonym: "CTP degradation" EXACT []
synonym: "CTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046036 ! CTP metabolic process

[Term]
id: GO:0006255
name: obsolete UDP reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "UDP reduction" EXACT []
is_obsolete: true
consider: GO:0051062

[Term]
id: GO:0006256
name: UDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732]
synonym: "UDP breakdown" EXACT []
synonym: "UDP catabolism" EXACT []
synonym: "UDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046048 ! UDP metabolic process

[Term]
id: GO:0006257
name: dUDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732]
synonym: "dUDP breakdown" EXACT []
synonym: "dUDP catabolism" EXACT []
synonym: "dUDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046077 ! dUDP metabolic process

[Term]
id: GO:0006258
name: UDP-alpha-D-glucose catabolic process
namespace: biological_process
alt_id: GO:0019691
def: "The chemical reactions and pathways resulting in the breakdown of UDP-alpha-D-glucose, a substance composed of UDP-alpha-D-glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-glucose breakdown" EXACT []
synonym: "UDP-glucose catabolism" EXACT []
synonym: "UDP-glucose conversion" RELATED []
synonym: "UDP-glucose degradation" EXACT []
is_a: GO:0006011 ! UDP-alpha-D-glucose metabolic process
is_a: GO:0009227 ! nucleotide-sugar catabolic process

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
alt_id: GO:0055132
def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "cellular DNA metabolism" EXACT []
synonym: "DNA metabolism" EXACT []
is_a: GO:0090304 ! nucleic acid metabolic process

[Term]
id: GO:0006260
name: DNA replication
namespace: biological_process
alt_id: GO:0055133
def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
xref: Wikipedia:DNA_replication
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006261
name: DNA-templated DNA replication
namespace: biological_process
alt_id: GO:0006262
alt_id: GO:0006263
def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
synonym: "DNA-dependent DNA replication" EXACT []
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0006264
name: mitochondrial DNA replication
namespace: biological_process
def: "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]
synonym: "mitochondrial DNA synthesis" RELATED []
synonym: "mtDNA replication" EXACT []
synonym: "mtDNA synthesis" RELATED []
synonym: "replication of mitochondrial DNA" EXACT []
is_a: GO:0006261 ! DNA-templated DNA replication
is_a: GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:0006265
name: DNA topological change
namespace: biological_process
def: "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
synonym: "DNA underwinding" NARROW []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0006266
name: DNA ligation
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194]
subset: goslim_pir
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006267
name: pre-replicative complex assembly involved in nuclear cell cycle DNA replication
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation." [GOC:mtg_cell_cycle]
synonym: "nuclear pre-replicative complex assembly" EXACT []
synonym: "pre-RC complex assembly" BROAD []
synonym: "pre-replicative complex assembly" BROAD [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "pre-replicative complex formation" BROAD []
is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0006268
name: DNA unwinding involved in DNA replication
namespace: biological_process
def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]
comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
synonym: "DNA unwinding during replication" RELATED [GOC:dph, GOC:tb]
synonym: "DNA unwinding factor" RELATED []
is_a: GO:0032508 ! DNA duplex unwinding
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0006269
name: DNA replication, synthesis of primer
namespace: biological_process
def: "The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718]
synonym: "DNA priming" NARROW []
synonym: "DNA replication, synthesis of DNA primer" NARROW []
synonym: "DNA replication, synthesis of RNA primer" NARROW []
synonym: "replication priming" RELATED []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0006270
name: DNA replication initiation
namespace: biological_process
alt_id: GO:0042024
def: "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]
synonym: "DNA endoreduplication initiation" NARROW []
synonym: "DNA re-replication initiation" NARROW []
synonym: "DNA-dependent DNA replication initiation" EXACT [GOC:vw]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0006271
name: DNA strand elongation involved in DNA replication
namespace: biological_process
def: "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194]
synonym: "DNA replication elongation" EXACT []
synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022616 ! DNA strand elongation
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0006272
name: leading strand elongation
namespace: biological_process
def: "The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194]
is_a: GO:0006271 ! DNA strand elongation involved in DNA replication

[Term]
id: GO:0006273
name: lagging strand elongation
namespace: biological_process
def: "The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194]
is_a: GO:0006271 ! DNA strand elongation involved in DNA replication

[Term]
id: GO:0006274
name: DNA replication termination
namespace: biological_process
def: "The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0006275
name: regulation of DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006260 ! DNA replication

[Term]
id: GO:0006276
name: plasmid maintenance
namespace: biological_process
def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006277
name: DNA amplification
namespace: biological_process
def: "The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464]
is_a: GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:0006278
name: RNA-templated DNA biosynthetic process
namespace: biological_process
def: "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732]
synonym: "RNA-dependent DNA biosynthetic process" EXACT []
is_a: GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:0006279
name: premeiotic DNA replication
namespace: biological_process
alt_id: GO:1902968
def: "The replication of DNA that precedes meiotic cell division." [GO_REF:0000060, GOC:ai, GOC:TermGenie]
synonym: "DNA replication during S phase involved in meiotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication involved in S phase involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication involved in S-phase involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "meiotic cell cycle DNA replication" EXACT []
synonym: "meiotic DNA replication" RELATED [GOC:mah]
synonym: "meiotic DNA synthesis" RELATED [GOC:mah]
synonym: "meiotic nuclear cell cycle DNA replication" EXACT []
synonym: "nuclear cell cycle DNA replication involved in meiotic cell cycle" EXACT []
synonym: "premeiotic DNA synthesis" RELATED [GOC:mah]
is_a: GO:0033260 ! nuclear DNA replication
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0006280
name: obsolete mutagenesis
namespace: biological_process
def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732]
comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent.
synonym: "mutagenesis" EXACT []
is_obsolete: true
consider: GO:0006281
consider: GO:0051276

[Term]
id: GO:0006281
name: DNA repair
namespace: biological_process
def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
xref: Wikipedia:DNA_repair
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0006974 ! DNA damage response

[Term]
id: GO:0006282
name: regulation of DNA repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]
subset: goslim_metagenomics
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0006281 ! DNA repair

[Term]
id: GO:0006283
name: transcription-coupled nucleotide-excision repair
namespace: biological_process
def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249]
synonym: "TC-NER" EXACT [PMID:10197977]
synonym: "TCR" RELATED [GOC:vw, PMID:18794354]
synonym: "transcription-coupled NER" EXACT [GOC:mah]
synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354]
is_a: GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006284
name: base-excision repair
namespace: biological_process
def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]
synonym: "BER" EXACT []
xref: Wikipedia:Base_excision_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006285
name: base-excision repair, AP site formation
namespace: biological_process
def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006286
name: obsolete base-excision repair, base-free sugar-phosphate removal
namespace: biological_process
def: "OBSOLETE. Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0003906
consider: GO:0017108

[Term]
id: GO:0006287
name: base-excision repair, gap-filling
namespace: biological_process
def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006288
name: base-excision repair, DNA ligation
namespace: biological_process
def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131]
is_a: GO:0051103 ! DNA ligation involved in DNA repair
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006289
name: nucleotide-excision repair
namespace: biological_process
alt_id: GO:0045001
def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
synonym: "intrastrand cross-link repair" RELATED []
synonym: "NER" EXACT []
synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT []
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006290
name: pyrimidine dimer repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194]
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006291
name: obsolete pyrimidine-dimer repair, DNA damage excision
namespace: biological_process
def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194]
comment: This term was made obsolete because this process can be subdivided into multiple processes.
synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT []
is_obsolete: true
consider: GO:0006289

[Term]
id: GO:0006292
name: obsolete pyrimidine-dimer repair, DNA damage recognition
namespace: biological_process
def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194]
comment: This term was made obsolete because it is a substrate specific DNA repair process.
synonym: "pyrimidine-dimer repair, DNA damage recognition" EXACT []
is_obsolete: true
consider: GO:0000715
consider: GO:0000716

[Term]
id: GO:0006293
name: nucleotide-excision repair, preincision complex stabilization
namespace: biological_process
def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006294
name: nucleotide-excision repair, preincision complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977]
synonym: "nucleotide-excision repair, preincision complex formation" EXACT []
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006295
name: obsolete nucleotide-excision repair, DNA incision, 3'-to lesion
namespace: biological_process
def: "OBSOLETE. The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977]
comment: This term was obsoleted because it represents a molecular function.
synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT []
is_obsolete: true
replaced_by: GO:0006289

[Term]
id: GO:0006296
name: obsolete nucleotide-excision repair, DNA incision, 5'-to lesion
namespace: biological_process
def: "OBSOLETE. The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977]
comment: This term was obsoleted because it represents a molecular function.
synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT []
is_obsolete: true
replaced_by: GO:0006289

[Term]
id: GO:0006297
name: nucleotide-excision repair, DNA gap filling
namespace: biological_process
def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006298
name: mismatch repair
namespace: biological_process
alt_id: GO:0006300
def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
synonym: "long patch mismatch repair system" NARROW []
synonym: "mismatch repair, MutL-like pathway" RELATED []
synonym: "MMR" EXACT []
synonym: "MutS/MutL/MutH pathway" RELATED []
xref: Wikipedia:DNA_mismatch_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006299
name: obsolete short patch mismatch repair system
namespace: biological_process
def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254]
comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair.
synonym: "short patch mismatch repair system" EXACT []
is_obsolete: true
consider: GO:0006284
consider: GO:0006289

[Term]
id: GO:0006301
name: postreplication repair
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh]
synonym: "postreplication DNA repair" EXACT []
xref: Wikipedia:Postreplication_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006302
name: double-strand break repair
namespace: biological_process
def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'.
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006303
name: double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]
synonym: "NHEJ" EXACT []
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0006304
name: DNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]
subset: goslim_pir
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0006305
name: obsolete DNA alkylation
namespace: biological_process
def: "OBSOLETE. The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0006306
name: obsolete DNA methylation
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]
comment: This term was obsoleted because it represents a molecular function.
xref: Wikipedia:DNA_methylation
is_obsolete: true
consider: GO:0009008
consider: GO:0009307
consider: GO:0031507

[Term]
id: GO:0006307
name: DNA alkylation repair
namespace: biological_process
def: "The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases." [PMID:10946226, PMID:35543797]
synonym: "DNA dealkylation involved in DNA repair" RELATED []
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006308
name: DNA catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]
synonym: "DNA breakdown" EXACT []
synonym: "DNA catabolism" EXACT []
synonym: "DNA degradation" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0141188 ! nucleic acid catabolic process

[Term]
id: GO:0006309
name: apoptotic DNA fragmentation
namespace: biological_process
alt_id: GO:0008178
def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis]
synonym: "DNA catabolic process during apoptosis" EXACT []
synonym: "DNA catabolism during apoptosis" EXACT []
synonym: "DNA fragmentation" BROAD []
synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb]
synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT []
is_a: GO:0006308 ! DNA catabolic process
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0006310
name: DNA recombination
namespace: biological_process
def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006311
name: meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194]
synonym: "gene conversion without reciprocal crossover" EXACT []
is_a: GO:0035822 ! gene conversion
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0006312
name: mitotic recombination
namespace: biological_process
def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles." [GOC:elh]
xref: Wikipedia:Mitotic_crossover
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0006313
name: DNA transposition
namespace: biological_process
alt_id: GO:0006317
alt_id: GO:0006318
def: "A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism." [ISBN:0198506732, ISBN:1555812090, PMID:26846462, PMID:30416149, PMID:32588192]
synonym: "Class II transposition" EXACT []
synonym: "transposition, DNA-mediated" EXACT []
xref: Wikipedia:Transposable_element
xref: Wikipedia:Transposase
is_a: GO:0006310 ! DNA recombination
is_a: GO:0032196 ! transposition

[Term]
id: GO:0006314
name: intron homing
namespace: biological_process
def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208]
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0006315
name: homing of group II introns
namespace: biological_process
def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208]
is_a: GO:0006314 ! intron homing

[Term]
id: GO:0006316
name: movement of group I intron
namespace: biological_process
def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208]
is_a: GO:0006314 ! intron homing

[Term]
id: GO:0006324
name: obsolete S phase-specific histone modification
namespace: biological_process
def: "OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026]
comment: This term was made obsolete because it represents a molecular function.
synonym: "S phase-specific histone modification" EXACT []
synonym: "S-phase-specific histone modification" EXACT []
is_obsolete: true

[Term]
id: GO:0006325
name: chromatin organization
namespace: biological_process
alt_id: GO:0006333
alt_id: GO:0006336
alt_id: GO:0016568
alt_id: GO:0031497
alt_id: GO:0034724
def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "chromatin assembly" NARROW []
synonym: "chromatin assembly or disassembly" RELATED []
synonym: "chromatin assembly/disassembly" RELATED []
synonym: "chromatin maintenance" BROAD []
synonym: "chromatin modification" RELATED []
synonym: "chromatin organisation" EXACT [GOC:mah]
synonym: "DNA replication-independent chromatin assembly" NARROW []
synonym: "DNA replication-independent chromatin organization" NARROW []
synonym: "DNA replication-independent nucleosome organisation" NARROW []
synonym: "DNA replication-independent nuclesome assembly" NARROW []
synonym: "establishment of chromatin architecture" EXACT [GOC:mah]
synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah]
synonym: "transcription-coupled nucleosome assembly" NARROW []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0006326
name: obsolete bent DNA binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "bent DNA binding" EXACT []
is_obsolete: true
replaced_by: GO:0003681

[Term]
id: GO:0006327
name: obsolete random coil binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "random coil binding" EXACT []
is_obsolete: true

[Term]
id: GO:0006328
name: obsolete AT binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "AT binding" EXACT []
is_obsolete: true
replaced_by: GO:0003680

[Term]
id: GO:0006329
name: obsolete satellite DNA binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "satellite DNA binding" EXACT []
is_obsolete: true
replaced_by: GO:0003696

[Term]
id: GO:0006330
name: obsolete single-stranded DNA binding
namespace: biological_process
alt_id: GO:0006331
alt_id: GO:0006332
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "single-stranded DNA binding" EXACT []
is_obsolete: true
replaced_by: GO:0003697

[Term]
id: GO:0006334
name: nucleosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
synonym: "histone chaperone" RELATED [GOC:vw]
synonym: "nucleosome modeling" EXACT []
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006325 ! chromatin organization

[Term]
id: GO:0006335
name: DNA replication-dependent chromatin assembly
namespace: biological_process
alt_id: GO:0034723
def: "The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation." [GOC:mah, PMID:28053344]
synonym: "DNA replication-dependent chromatin organization" RELATED []
synonym: "DNA replication-dependent nucleosome assembly" BROAD []
synonym: "DNA replication-dependent nucleosome organisation" RELATED []
synonym: "DNA replication-dependent nucleosome organization" RELATED []
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0006337
name: nucleosome disassembly
namespace: biological_process
def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
is_a: GO:0032986 ! protein-DNA complex disassembly
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0006338
name: chromatin remodeling
namespace: biological_process
alt_id: GO:0043044
def: "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
synonym: "ATP-dependent chromatin remodeling" NARROW []
synonym: "ATP-dependent chromatin remodelling" NARROW []
synonym: "chromatin modeling" EXACT []
synonym: "chromatin modelling" EXACT []
synonym: "chromatin remodelling" EXACT []
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0006339
name: obsolete positive regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "positive regulation of transcription of homeotic gene (trithorax group)" EXACT []
is_obsolete: true
consider: GO:0031507
consider: GO:0045815
consider: GO:0045944

[Term]
id: GO:0006340
name: obsolete negative regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "negative regulation of transcription of homeotic gene (Polycomb group)" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0031507
consider: GO:0045815

[Term]
id: GO:0006341
name: obsolete chromatin insulator sequence binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "chromatin insulator sequence binding" EXACT []
is_obsolete: true
replaced_by: GO:0043035

[Term]
id: GO:0006346
name: DNA methylation-dependent constitutive heterochromatin formation
namespace: biological_process
def: "Formation of constitutive heterochromatin by a pathway that includes methylation of genomic DNA such as CpG islands." [GOC:mah]
synonym: "DNA methylation-dependent heterochromatin assembly" EXACT []
synonym: "DNA methylation-dependent heterochromatin formation" EXACT []
synonym: "methylation-dependent chromatin silencing" BROAD []
synonym: "methylation-dependent heterochromatic silencing" BROAD []
is_a: GO:0140719 ! constitutive heterochromatin formation

[Term]
id: GO:0006349
name: obsolete regulation of gene expression by genomic imprinting
namespace: biological_process
def: "OBSOLETE. An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles." [PMID:11498578, PMID:31896690, PMID:7502071]
comment: This term was obsoleted because it represents the same concept as its parent, GO:0071514 genomic imprinting, also a regulatory process.
synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah]
synonym: "regulation of gene expression by genetic imprinting" RELATED []
xref: Wikipedia:Genomic_imprinting
is_obsolete: true
replaced_by: GO:0071514

[Term]
id: GO:0006351
name: DNA-templated transcription
namespace: biological_process
alt_id: GO:0001121
alt_id: GO:0006350
alt_id: GO:0061018
alt_id: GO:0061022
def: "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "bacterial transcription" NARROW []
synonym: "cellular transcription" BROAD []
synonym: "DNA-dependent transcription" EXACT []
synonym: "transcription" BROAD []
synonym: "transcription from bacterial-type RNA polymerase promoter" NARROW []
synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "transcription, DNA-templated" EXACT []
xref: Wikipedia:Transcription_(genetics)
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006352
name: DNA-templated transcription initiation
namespace: biological_process
alt_id: GO:0001123
def: "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
subset: goslim_yeast
synonym: "DNA-dependent RNA polymerase complex assembly at promoter" EXACT []
synonym: "DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "DNA-templated transcription, initiation" EXACT []
synonym: "initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "initiation of transcription, DNA-dependent" EXACT [GOC:mah]
synonym: "transcription initiation factor activity" RELATED []
synonym: "transcription initiation from bacterial-type RNA polymerase promoter" NARROW []
synonym: "transcription initiation, DNA-dependent" RELATED [GOC:jh2]
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0006353
name: DNA-templated transcription termination
namespace: biological_process
alt_id: GO:0001125
def: "The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template." [GOC:txnOH, PMID:15020047, PMID:18280161, PMID:30978344]
subset: goslim_yeast
synonym: "DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "DNA-templated transcription, termination" EXACT []
synonym: "termination of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "termination of transcription, DNA-dependent" EXACT [GOC:mah]
synonym: "transcription termination factor activity" RELATED []
synonym: "transcription termination from bacterial-type RNA polymerase promoter" NARROW []
synonym: "transcription termination, DNA-dependent" RELATED [GOC:jh2]
synonym: "transcriptional complex disassembly" BROAD []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0006354
name: DNA-templated transcription elongation
namespace: biological_process
alt_id: GO:0001124
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]
subset: goslim_pir
subset: goslim_yeast
synonym: "DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "DNA-templated transcription, elongation" EXACT []
synonym: "RNA elongation" BROAD []
synonym: "RNA elongation from bacterial-type RNA polymerase promoter" NARROW []
synonym: "transcription elongation from bacterial-type RNA polymerase promoter" NARROW []
synonym: "transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "transcriptional elongation, DNA-dependent" EXACT []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0006355
name: regulation of DNA-templated transcription
namespace: biological_process
alt_id: GO:0032583
alt_id: GO:0045449
alt_id: GO:0061019
def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "regulation of gene-specific transcription" RELATED []
synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "regulation of transcription, DNA-templated" EXACT []
synonym: "transcriptional control" BROAD []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:2001141 ! regulation of RNA biosynthetic process
relationship: regulates GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0006356
name: regulation of transcription by RNA polymerase I
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators]
synonym: "regulation of transcription from Pol I promoter" EXACT []
synonym: "regulation of transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0006360 ! transcription by RNA polymerase I

[Term]
id: GO:0006357
name: regulation of transcription by RNA polymerase II
namespace: biological_process
alt_id: GO:0006358
alt_id: GO:0010551
def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]
synonym: "global transcription regulation from Pol II promoter" RELATED []
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "regulation of global transcription from Pol II promoter" RELATED []
synonym: "regulation of transcription from Pol II promoter" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED []
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0006366 ! transcription by RNA polymerase II

[Term]
id: GO:0006359
name: regulation of transcription by RNA polymerase III
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III." [GOC:go_curators]
synonym: "regulation of transcription from Pol III promoter" EXACT []
synonym: "regulation of transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0006383 ! transcription by RNA polymerase III

[Term]
id: GO:0006360
name: transcription by RNA polymerase I
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
subset: goslim_yeast
synonym: "RNA polymerase I transcription factor activity" RELATED []
synonym: "transcription from Pol I promoter" EXACT []
synonym: "transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0006361
name: transcription initiation at RNA polymerase I promoter
namespace: biological_process
alt_id: GO:0001180
def: "A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I." [GOC:txnOH]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
synonym: "transcription initiation from Pol I promoter" EXACT []
synonym: "transcription initiation from RNA polymerase I promoter" EXACT []
synonym: "transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" NARROW []
is_a: GO:0006352 ! DNA-templated transcription initiation
relationship: part_of GO:0006360 ! transcription by RNA polymerase I

[Term]
id: GO:0006362
name: transcription elongation by RNA polymerase I
namespace: biological_process
alt_id: GO:0001183
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from Pol I promoter" EXACT []
synonym: "RNA polymerase I transcription elongation factor activity" RELATED []
synonym: "transcription elongation from RNA polymerase I promoter" EXACT []
synonym: "transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript" RELATED []
is_a: GO:0006354 ! DNA-templated transcription elongation
relationship: part_of GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I

[Term]
id: GO:0006363
name: termination of RNA polymerase I transcription
namespace: biological_process
alt_id: GO:0001185
alt_id: GO:0019223
def: "A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922, PMID:27371117]
synonym: "RNA polymerase I transcription termination" EXACT []
synonym: "RNA polymerase I transcription termination factor activity" RELATED []
synonym: "termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript" NARROW []
synonym: "transcription termination from Pol I promoter" EXACT []
synonym: "transcription termination from RNA polymerase I promoter" EXACT []
is_a: GO:0006353 ! DNA-templated transcription termination
relationship: part_of GO:0006360 ! transcription by RNA polymerase I

[Term]
id: GO:0006364
name: rRNA processing
namespace: biological_process
alt_id: GO:0006365
def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
subset: goslim_yeast
synonym: "35S primary transcript processing" NARROW []
is_a: GO:0006396 ! RNA processing
is_a: GO:0016072 ! rRNA metabolic process
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0006366
name: transcription by RNA polymerase II
namespace: biological_process
alt_id: GO:0032568
alt_id: GO:0032569
def: "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
subset: goslim_yeast
synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "general transcription from RNA polymerase II promoter" RELATED []
synonym: "RNA polymerase II transcription factor activity" RELATED []
synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah]
synonym: "transcription from Pol II promoter" EXACT []
synonym: "transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0006367
name: transcription initiation at RNA polymerase II promoter
namespace: biological_process
def: "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
synonym: "transcription initiation from Pol II promoter" EXACT []
synonym: "transcription initiation from RNA polymerase II promoter" EXACT []
is_a: GO:0006352 ! DNA-templated transcription initiation
relationship: part_of GO:0006366 ! transcription by RNA polymerase II

[Term]
id: GO:0006368
name: transcription elongation by RNA polymerase II
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from Pol II promoter" EXACT []
synonym: "RNA polymerase II transcription elongation factor activity" RELATED []
synonym: "transcription elongation by RNA polymerase II promoter" EXACT []
synonym: "transcription elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0006354 ! DNA-templated transcription elongation
relationship: part_of GO:0006366 ! transcription by RNA polymerase II

[Term]
id: GO:0006369
name: termination of RNA polymerase II transcription
namespace: biological_process
alt_id: GO:0019224
def: "A transcription termination process that completes the production of a primary RNA polymerase II transcript." [GOC:mah, GOC:txnOH, PMID:27371117]
synonym: "RNA 3'-end formation by RNA polymerase II" EXACT []
synonym: "RNA polymerase II transcription termination" EXACT []
synonym: "RNA polymerase II transcription termination factor activity" RELATED []
synonym: "transcription termination from Pol II promoter" EXACT []
synonym: "transcription termination from RNA polymerase II promoter" EXACT []
is_a: GO:0006353 ! DNA-templated transcription termination
relationship: part_of GO:0006366 ! transcription by RNA polymerase II

[Term]
id: GO:0006370
name: 7-methylguanosine mRNA capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:mah, PMID:9266685]
synonym: "5' end capping" BROAD []
synonym: "5' mRNA capping" EXACT []
synonym: "5'-end mRNA processing" EXACT []
synonym: "5'-end processing" BROAD []
synonym: "mRNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah]
is_a: GO:0006397 ! mRNA processing
is_a: GO:0009452 ! 7-methylguanosine RNA capping

[Term]
id: GO:0006371
name: obsolete mRNA splicing
namespace: biological_process
def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732]
comment: This term was made obsolete because it represents several different processes.
synonym: "mRNA splicing" EXACT []
is_obsolete: true
consider: GO:0000372
consider: GO:0000373
consider: GO:0000374
consider: GO:0000394
consider: GO:0000398

[Term]
id: GO:0006372
name: obsolete lariat formation, 5'-splice site cleavage
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a molecular function.
synonym: "lariat formation, 5'-splice site cleavage" EXACT []
is_obsolete: true
consider: GO:0000350
consider: GO:0000386

[Term]
id: GO:0006373
name: obsolete 3'-splice site cleavage, exon ligation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a molecular function.
synonym: "3'-splice site cleavage, exon ligation" EXACT []
is_obsolete: true
consider: GO:0000386
consider: GO:0000388
consider: GO:0000393

[Term]
id: GO:0006376
name: mRNA splice site recognition
namespace: biological_process
def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
synonym: "spliceosomal commitment complex biosynthesis" NARROW []
synonym: "spliceosomal commitment complex formation" NARROW []
synonym: "spliceosomal E complex biosynthesis" NARROW []
synonym: "spliceosomal E complex formation" NARROW []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly

[Term]
id: GO:0006377
name: obsolete MATa1 (A1) pre-mRNA splicing
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene.
synonym: "MATa1 (A1) pre-mRNA splicing" EXACT []
is_obsolete: true
consider: GO:0000244

[Term]
id: GO:0006378
name: obsolete mRNA polyadenylation
namespace: biological_process
def: "OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
consider: GO:0006397
consider: GO:0097222
consider: GO:0180010

[Term]
id: GO:0006379
name: obsolete mRNA cleavage
namespace: biological_process
def: "OBSOLETE. Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function
synonym: "cleavage stimulation factor activity" RELATED []
is_obsolete: true

[Term]
id: GO:0006380
name: obsolete poly-A binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "poly-A binding" EXACT []
is_obsolete: true
consider: GO:0008143

[Term]
id: GO:0006382
name: adenosine to inosine editing
namespace: biological_process
def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837]
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0006383
name: transcription by RNA polymerase III
namespace: biological_process
alt_id: GO:0001009
alt_id: GO:0001035
alt_id: GO:0001041
def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]
subset: goslim_yeast
synonym: "RNA polymerase III transcription factor activity" RELATED []
synonym: "transcription from a RNA polymerase III hybrid type promoter" NARROW []
synonym: "transcription from Pol III promoter" EXACT []
synonym: "transcription from RNA polymerase III promoter" EXACT []
synonym: "transcription from RNA polymerase III type 2 promoter" NARROW []
synonym: "transcription from RNA polymerase III type 3 promoter" NARROW []
synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW []
synonym: "U6 snRNA transcription (mammalian)" NARROW []
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0006384
name: transcription initiation at RNA polymerase III promoter
namespace: biological_process
alt_id: GO:0001022
alt_id: GO:0001023
alt_id: GO:0001024
alt_id: GO:0001036
def: "A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
synonym: "transcription initiation from Pol III promoter" EXACT []
synonym: "transcription initiation from RNA polymerase III hybrid type promoter" NARROW []
synonym: "transcription initiation from RNA polymerase III promoter" EXACT []
synonym: "transcription initiation from RNA polymerase III type 1 promoter" NARROW []
synonym: "transcription initiation from RNA polymerase III type 2 promoter" NARROW []
synonym: "transcription initiation from RNA polymerase III type 3 promoter" NARROW []
is_a: GO:0006352 ! DNA-templated transcription initiation
relationship: part_of GO:0006383 ! transcription by RNA polymerase III

[Term]
id: GO:0006385
name: transcription elongation by RNA polymerase III
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from Pol III promoter" EXACT []
synonym: "RNA polymerase III transcription elongation factor activity" RELATED []
synonym: "transcription elongation by RNA polymerase III promoter" EXACT []
synonym: "transcription elongation from RNA polymerase III promoter" EXACT []
is_a: GO:0006354 ! DNA-templated transcription elongation
relationship: part_of GO:0006383 ! transcription by RNA polymerase III

[Term]
id: GO:0006386
name: termination of RNA polymerase III transcription
namespace: biological_process
alt_id: GO:0019225
def: "A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues." [GOC:mah, PMID:12944462, PMID:27371117]
synonym: "RNA polymerase III transcription termination" EXACT []
synonym: "RNA polymerase III transcription termination factor activity" RELATED []
synonym: "transcription termination from Pol III promoter" EXACT []
synonym: "transcription termination from RNA polymerase III promoter" EXACT []
is_a: GO:0006353 ! DNA-templated transcription termination
relationship: part_of GO:0006383 ! transcription by RNA polymerase III

[Term]
id: GO:0006387
name: obsolete snRNA capping
namespace: biological_process
def: "OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript." [GOC:mah]
comment: This term was made obsolete because it has been replaced with a more specific term to describe cap hypermethylation. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the 7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap.
synonym: "snRNA capping" EXACT []
is_obsolete: true
consider: GO:0036261

[Term]
id: GO:0006388
name: tRNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]
comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
synonym: "tRNA-Y splicing" NARROW []
is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0006389
name: obsolete tRNA-Y splicing
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA.
synonym: "tRNA-Y splicing" EXACT []
is_obsolete: true
consider: GO:0006388

[Term]
id: GO:0006390
name: mitochondrial transcription
namespace: biological_process
def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl, PMID:23632312]
synonym: "transcription from mitochondrial promoter" EXACT []
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006351 ! DNA-templated transcription
relationship: part_of GO:0140053 ! mitochondrial gene expression

[Term]
id: GO:0006391
name: transcription initiation at mitochondrial promoter
namespace: biological_process
def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome." [PMID:33127643]
synonym: "transcription initiation from mitochondrial promoter" EXACT []
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006352 ! DNA-templated transcription initiation
relationship: part_of GO:0006390 ! mitochondrial transcription

[Term]
id: GO:0006392
name: transcription elongation by mitochondrial RNA polymerase
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from mitochondrial promoter" EXACT []
synonym: "transcription elongation from mitochondrial promoter" EXACT []
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006354 ! DNA-templated transcription elongation
relationship: part_of GO:0006390 ! mitochondrial transcription

[Term]
id: GO:0006393
name: termination of mitochondrial transcription
namespace: biological_process
def: "A transcription termination process that completes the production of a primary mitochondrial transcript." [PMID:29945721]
synonym: "mitochondrial transcription termination" EXACT []
synonym: "RNA transcription termination from mitochondrial promoter" EXACT []
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006353 ! DNA-templated transcription termination
relationship: part_of GO:0006390 ! mitochondrial transcription

[Term]
id: GO:0006396
name: RNA processing
namespace: biological_process
alt_id: GO:0006394
def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
subset: goslim_drosophila
subset: goslim_pir
xref: Wikipedia:Post-transcriptional_modification
is_a: GO:0044238 ! primary metabolic process
relationship: part_of GO:0010467 ! gene expression
relationship: part_of GO:0032774 ! RNA biosynthetic process

[Term]
id: GO:0006397
name: mRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
subset: goslim_chembl
subset: goslim_yeast
synonym: "mRNA maturation" RELATED []
is_a: GO:0006396 ! RNA processing
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0006398
name: mRNA 3'-end processing by stem-loop binding and cleavage
namespace: biological_process
def: "Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine." [GOC:mah, GOC:tb, PMID:17998288]
synonym: "histone mRNA 3' end processing" NARROW []
is_a: GO:0008334 ! histone mRNA metabolic process
is_a: GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0006399
name: tRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
synonym: "tRNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0006400
name: tRNA modification
namespace: biological_process
alt_id: GO:0016549
def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
synonym: "tRNA editing" NARROW [GOC:hjd]
is_a: GO:0008033 ! tRNA processing
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0006401
name: RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_yeast
synonym: "RNA breakdown" EXACT []
synonym: "RNA catabolism" EXACT []
synonym: "RNA degradation" EXACT []
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0141188 ! nucleic acid catabolic process

[Term]
id: GO:0006402
name: mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
synonym: "mRNA breakdown" EXACT []
synonym: "mRNA catabolism" EXACT []
synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb]
synonym: "mRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0006403
name: RNA localization
namespace: biological_process
def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]
subset: goslim_drosophila
synonym: "establishment and maintenance of RNA localization" EXACT []
synonym: "RNA localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0006404
name: RNA import into nucleus
namespace: biological_process
def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma]
synonym: "RNA import into cell nucleus" EXACT []
synonym: "RNA transport from cytoplasm to nucleus" EXACT []
synonym: "RNA-nucleus import" EXACT []
is_a: GO:0050658 ! RNA transport
is_a: GO:0051170 ! import into nucleus

[Term]
id: GO:0006405
name: RNA export from nucleus
namespace: biological_process
def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "RNA export from cell nucleus" EXACT []
synonym: "RNA export out of nucleus" EXACT []
synonym: "RNA transport from nucleus to cytoplasm" EXACT []
synonym: "RNA-nucleus export" EXACT []
is_a: GO:0050658 ! RNA transport
is_a: GO:0051168 ! nuclear export

[Term]
id: GO:0006406
name: mRNA export from nucleus
namespace: biological_process
def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "mRNA export from cell nucleus" EXACT []
synonym: "mRNA export out of nucleus" EXACT []
synonym: "mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "mRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051028 ! mRNA transport
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006407
name: obsolete rRNA export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah]
comment: The reason for obsoletion is that this term was added in error (rRNA is only exported as part of the pre ribosome).
synonym: "rRNA export from cell nucleus" EXACT []
synonym: "rRNA export out of nucleus" EXACT []
synonym: "rRNA transport from nucleus to cytoplasm" EXACT []
synonym: "rRNA-nucleus export" EXACT []
is_obsolete: true
replaced_by: GO:0000054

[Term]
id: GO:0006408
name: snRNA export from nucleus
namespace: biological_process
def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "snRNA export from cell nucleus" EXACT []
synonym: "snRNA export out of nucleus" EXACT []
synonym: "snRNA transport from nucleus to cytoplasm" EXACT []
synonym: "snRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051030 ! snRNA transport

[Term]
id: GO:0006409
name: tRNA export from nucleus
namespace: biological_process
def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "tRNA export from cell nucleus" EXACT []
synonym: "tRNA export out of nucleus" EXACT []
synonym: "tRNA transport from nucleus to cytoplasm" EXACT []
synonym: "tRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051031 ! tRNA transport

[Term]
id: GO:0006410
name: obsolete transcription, RNA-dependent
namespace: biological_process
def: "OBSOLETE. The cellular synthesis of DNA on a template of RNA." [GOC:jl]
comment: This term was obsoleted because the name and the definition mean two completely different things: 1) "transcription, RNA-dependent", i.e. RNA-dependent production of an RNA transcript and 2) "reverse transcription", i.e. RNA-dependent DNA synthesis.
synonym: "transcription, RNA-dependent" EXACT []
is_obsolete: true

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein biosynthetic process" EXACT []
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Wikipedia:Translation_(genetics)
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0019538 ! protein metabolic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006413
name: translational initiation
namespace: biological_process
alt_id: GO:0006440
alt_id: GO:0006454
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
subset: goslim_yeast
synonym: "biopolymerisation" BROAD []
synonym: "biopolymerization" BROAD []
synonym: "protein synthesis initiation" BROAD []
synonym: "translation initiation" EXACT []
is_a: GO:0008152 ! metabolic process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006414
name: translational elongation
namespace: biological_process
alt_id: GO:0006442
alt_id: GO:0006455
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
subset: goslim_yeast
synonym: "protein synthesis elongation" BROAD []
synonym: "translation elongation" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006415
name: translational termination
namespace: biological_process
alt_id: GO:0006443
alt_id: GO:0006456
def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]
synonym: "protein synthesis termination" BROAD []
synonym: "translation termination" EXACT []
synonym: "translational complex disassembly" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006417
name: regulation of translation
namespace: biological_process
alt_id: GO:0006445
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]
subset: goslim_yeast
synonym: "regulation of protein anabolism" EXACT []
synonym: "regulation of protein biosynthesis" EXACT []
synonym: "regulation of protein formation" EXACT []
synonym: "regulation of protein synthesis" EXACT []
is_a: GO:0010608 ! post-transcriptional regulation of gene expression
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0006412 ! translation

[Term]
id: GO:0006418
name: tRNA aminoacylation for protein translation
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
subset: goslim_yeast
synonym: "tRNA charging" NARROW []
xref: MetaCyc:TRNA-CHARGING-PWY
is_a: GO:0043039 ! tRNA aminoacylation
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006419
name: alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006420
name: arginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006421
name: asparaginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006422
name: aspartyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA." [GOC:mah, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006423
name: cysteinyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006424
name: glutamyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006425
name: glutaminyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006426
name: glycyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006427
name: histidyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006428
name: isoleucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006429
name: leucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006430
name: lysyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006431
name: methionyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006432
name: phenylalanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006433
name: prolyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA." [GOC:mah, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006434
name: seryl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006435
name: threonyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006436
name: tryptophanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006437
name: tyrosyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006438
name: valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006439
name: obsolete aminoacyl-tRNA hydrolase reaction
namespace: biological_process
def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X]
comment: This term was made obsolete because it represents a molecular function.
synonym: "aminoacyl-tRNA hydrolase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004045

[Term]
id: GO:0006441
name: obsolete binding to mRNA cap
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "binding to mRNA cap" EXACT []
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0006446
name: regulation of translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
relationship: regulates GO:0006413 ! translational initiation

[Term]
id: GO:0006447
name: regulation of translational initiation by iron
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl]
is_a: GO:0006446 ! regulation of translational initiation

[Term]
id: GO:0006448
name: regulation of translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
relationship: regulates GO:0006414 ! translational elongation

[Term]
id: GO:0006449
name: regulation of translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
relationship: regulates GO:0006415 ! translational termination

[Term]
id: GO:0006450
name: regulation of translational fidelity
namespace: biological_process
alt_id: GO:0000029
def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
synonym: "regulation of translational accuracy" EXACT []
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0006451
name: translational readthrough
namespace: biological_process
def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg, PMID:11179232]
synonym: "natural nonsense suppression" RELATED []
is_a: GO:0006414 ! translational elongation
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0006452
name: translational frameshifting
namespace: biological_process
def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425]
xref: Wikipedia:Translational_frameshift
is_a: GO:0006414 ! translational elongation

[Term]
id: GO:0006457
name: protein folding
namespace: biological_process
alt_id: GO:0007022
alt_id: GO:0007024
alt_id: GO:0007025
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "alpha-tubulin folding" NARROW [GOC:mah]
synonym: "beta-tubulin folding" NARROW [GOC:mah]
synonym: "chaperone activity" RELATED []
synonym: "chaperonin ATPase activity" RELATED []
synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah]
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" RELATED []
xref: Wikipedia:Protein_folding
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0051604 ! protein maturation

[Term]
id: GO:0006458
name: 'de novo' protein folding
namespace: biological_process
def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]
synonym: "nascent chain protein folding" EXACT []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0006459
name: obsolete binding unfolded ER proteins
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "binding unfolded ER proteins" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0051082

[Term]
id: GO:0006460
name: obsolete peptidyl-prolyl isomerase B reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "peptidyl-prolyl isomerase B reaction" EXACT []
is_obsolete: true
consider: GO:0003755

[Term]
id: GO:0006462
name: obsolete protein complex assembly, multichaperone pathway
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown.
synonym: "protein complex assembly, multichaperone pathway" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051131

[Term]
id: GO:0006463
name: steroid hormone receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0006465
name: signal peptide processing
namespace: biological_process
def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, PMID:31214988]
synonym: "leader peptide processing" EXACT []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0006466
name: obsolete protein disulfide-isomerase reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it presents a molecular function.
synonym: "protein disulfide-isomerase reaction" EXACT []
synonym: "protein disulphide-isomerase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0003756

[Term]
id: GO:0006468
name: protein phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a protein." [GOC:hb]
subset: gocheck_obsoletion_candidate
subset: goslim_yeast
synonym: "protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0016310 ! phosphorylation
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0006469
name: negative regulation of protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein kinase activity" EXACT []
synonym: "down-regulation of protein kinase activity" EXACT []
synonym: "downregulation of protein kinase activity" EXACT []
synonym: "inhibition of protein kinase activity" NARROW []
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0006470
name: protein dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb]
subset: gocheck_obsoletion_candidate
subset: goslim_yeast
synonym: "protein amino acid dephosphorylation" EXACT [GOC:bf]
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0006471
name: obsolete protein ADP-ribosylation
namespace: biological_process
def: "OBSOLETE. The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid ADP-ribosylation" EXACT [GOC:bf]
xref: RESID:AA0040
xref: RESID:AA0168
xref: RESID:AA0169
xref: RESID:AA0231
xref: RESID:AA0237
xref: RESID:AA0295
is_obsolete: true
consider: GO:1990404

[Term]
id: GO:0006473
name: protein acetylation
namespace: biological_process
def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid acetylation" EXACT [GOC:bf]
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0006474
name: N-terminal protein amino acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "N(alpha)-terminal acetylation" NARROW [PMID:11013267]
is_a: GO:0006473 ! protein acetylation
is_a: GO:0031365 ! N-terminal protein amino acid modification
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0006475
name: internal protein amino acid acetylation
namespace: biological_process
def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006473 ! protein acetylation

[Term]
id: GO:0006476
name: protein deacetylation
namespace: biological_process
def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid deacetylation" EXACT [GOC:bf]
is_a: GO:0035601 ! protein deacylation

[Term]
id: GO:0006477
name: protein sulfation
namespace: biological_process
def: "The addition of a sulfate group as an ester to a protein amino acid." [GOC:curators]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid sulfation" EXACT [GOC:bf]
synonym: "protein amino acid sulphation" EXACT []
is_a: GO:0036211 ! protein modification process
is_a: GO:0051923 ! sulfation

[Term]
id: GO:0006478
name: peptidyl-tyrosine sulfation
namespace: biological_process
def: "The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]
subset: gocheck_obsoletion_candidate
synonym: "peptidyl-tyrosine sulphation" EXACT []
xref: RESID:AA0172
is_a: GO:0006477 ! protein sulfation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0006479
name: protein methylation
namespace: biological_process
def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid methylation" EXACT [GOC:bf]
is_a: GO:0008213 ! protein alkylation
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0006480
name: N-terminal protein amino acid methylation
namespace: biological_process
def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0006479 ! protein methylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0006481
name: C-terminal protein methylation
namespace: biological_process
def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "C-terminal protein amino acid methylation" EXACT [GOC:bf]
is_a: GO:0006479 ! protein methylation
is_a: GO:0018410 ! C-terminal protein amino acid modification

[Term]
id: GO:0006482
name: protein demethylation
namespace: biological_process
def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid demethylation" EXACT [GOC:bf]
is_a: GO:0008214 ! protein dealkylation
is_a: GO:0070988 ! demethylation

[Term]
id: GO:0006483
name: obsolete peptidyl-aspartic acid/asparagine hydroxylation
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
synonym: "aspartic acid/asparagine hydroxylation" EXACT []
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" EXACT []
is_obsolete: true
consider: GO:0036140
consider: GO:0062101

[Term]
id: GO:0006484
name: obsolete protein cysteine-thiol oxidation
namespace: biological_process
def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025]
comment: This term was made obsolete because it represents a single activity.
synonym: "protein cysteine-thiol oxidation" EXACT []
is_obsolete: true
consider: GO:0003756

[Term]
id: GO:0006486
name: protein glycosylation
namespace: biological_process
alt_id: GO:0065006
def: "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "protein amino acid glycosylation" EXACT [GOC:bf]
synonym: "protein-carbohydrate complex assembly" RELATED []
is_a: GO:0036211 ! protein modification process
is_a: GO:0043413 ! macromolecule glycosylation
relationship: part_of GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0006487
name: protein N-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
synonym: "N-glycan biosynthesis" RELATED []
synonym: "N-glycan metabolism" RELATED []
synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf]
xref: RESID:AA0151
xref: RESID:AA0156
xref: RESID:AA0327
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0006488
name: dolichol-linked oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]
synonym: "dolichol-linked oligosaccharide anabolism" EXACT []
synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT []
synonym: "dolichol-linked oligosaccharide formation" EXACT []
synonym: "dolichol-linked oligosaccharide synthesis" EXACT []
synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161]
synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161]
synonym: "oligosaccharide-PP-dolichol assembly" EXACT []
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
relationship: part_of GO:0018279 ! protein N-linked glycosylation via asparagine

[Term]
id: GO:0006489
name: dolichyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732]
synonym: "dolichyl diphosphate anabolism" EXACT []
synonym: "dolichyl diphosphate biosynthesis" EXACT []
synonym: "dolichyl diphosphate formation" EXACT []
synonym: "dolichyl diphosphate synthesis" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0046465 ! dolichyl diphosphate metabolic process
relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process

[Term]
id: GO:0006490
name: obsolete oligosaccharide-lipid intermediate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete, GOC:pr, GOC:rb]
comment: This term was obsoleted because it is an unnecessary grouping term
synonym: "oligosaccharide-lipid intermediate assembly" NARROW [GOC:pr]
is_obsolete: true
replaced_by: GO:0006488

[Term]
id: GO:0006491
name: N-glycan processing
namespace: biological_process
alt_id: GO:0006492
def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]
synonym: "glycoprotein trimming involved in glycoprotein maturation" NARROW []
synonym: "N-linked glycoprotein maturation" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006493
name: protein O-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, PMID:33775405]
synonym: "protein amino acid O-linked glycosylation" EXACT [GOC:bf]
xref: RESID:AA0153
xref: RESID:AA0154
xref: RESID:AA0155
xref: RESID:AA0157
xref: RESID:AA0212
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0006494
name: obsolete protein amino acid terminal glycosylation
namespace: biological_process
def: "OBSOLETE. A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg]
comment: This term was made obsolete because the term name is ambiguous.
synonym: "protein amino acid terminal glycosylation" EXACT []
is_obsolete: true
consider: GO:0006486

[Term]
id: GO:0006495
name: obsolete terminal O-glycosylation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "terminal O-glycosylation" EXACT []
is_obsolete: true

[Term]
id: GO:0006496
name: obsolete protein amino acid terminal N-glycosylation
namespace: biological_process
def: "OBSOLETE. The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg]
comment: This term was made obsolete because the term name is ambiguous.
synonym: "protein amino acid terminal N-glycosylation" EXACT []
is_obsolete: true
consider: GO:0006487

[Term]
id: GO:0006497
name: protein lipidation
namespace: biological_process
alt_id: GO:0042050
def: "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]
comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children.
subset: gocheck_obsoletion_candidate
subset: goslim_drosophila
subset: goslim_yeast
synonym: "lipid:protein modification" EXACT []
synonym: "protein amino acid lipidation" EXACT [GOC:bf]
xref: RESID:AA0059
xref: RESID:AA0060
xref: RESID:AA0077
xref: RESID:AA0078
xref: RESID:AA0079
xref: RESID:AA0080
xref: RESID:AA0102
xref: RESID:AA0103
xref: RESID:AA0104
xref: RESID:AA0106
xref: RESID:AA0107
xref: RESID:AA0158
xref: RESID:AA0159
xref: RESID:AA0160
xref: RESID:AA0161
xref: RESID:AA0162
xref: RESID:AA0163
xref: RESID:AA0166
xref: RESID:AA0223
xref: RESID:AA0290
xref: RESID:AA0307
xref: RESID:AA0308
xref: RESID:AA0309
xref: RESID:AA0316
is_a: GO:0036211 ! protein modification process
relationship: part_of GO:0042158 ! lipoprotein biosynthetic process

[Term]
id: GO:0006498
name: N-terminal protein lipidation
namespace: biological_process
def: "The covalent attachment of a lipid group to the amino terminus of a protein." [GOC:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0006497 ! protein lipidation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0006499
name: N-terminal protein myristoylation
namespace: biological_process
def: "The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006498 ! N-terminal protein lipidation
is_a: GO:0018377 ! protein myristoylation

[Term]
id: GO:0006500
name: N-terminal protein palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006498 ! N-terminal protein lipidation
is_a: GO:0018345 ! protein palmitoylation

[Term]
id: GO:0006501
name: C-terminal protein lipidation
namespace: biological_process
def: "The covalent attachment of a lipid group to the carboxy-terminus of a protein." [GOC:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0006497 ! protein lipidation
is_a: GO:0018410 ! C-terminal protein amino acid modification

[Term]
id: GO:0006502
name: obsolete C-terminal protein prenylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl group to the carboxy-terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein.
synonym: "C-terminal protein prenylation" EXACT []
is_obsolete: true
replaced_by: GO:0018342

[Term]
id: GO:0006503
name: obsolete C-terminal protein farnesylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein.
synonym: "C-terminal protein farnesylation" EXACT []
is_obsolete: true
replaced_by: GO:0018343

[Term]
id: GO:0006504
name: obsolete C-terminal protein geranylgeranylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy-terminus of a protein." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein.
synonym: "C-terminal protein geranylgeranylation" EXACT []
is_obsolete: true
replaced_by: GO:0018344

[Term]
id: GO:0006505
name: GPI anchor metabolic process
namespace: biological_process
alt_id: GO:0046472
def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732]
synonym: "glycosylphosphatidylinositol metabolic process" EXACT []
synonym: "glycosylphosphatidylinositol metabolism" EXACT []
synonym: "GPI anchor metabolism" EXACT []
synonym: "GPI/GSI anchor metabolic process" BROAD []
synonym: "GPI/GSI anchor metabolism" BROAD []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0006506
name: GPI anchor biosynthetic process
namespace: biological_process
alt_id: GO:0015998
def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
synonym: "glycosylphosphatidylinositol biosynthesis" EXACT []
synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT []
synonym: "GPI anchor anabolism" EXACT []
synonym: "GPI anchor biosynthesis" EXACT []
synonym: "GPI anchor formation" EXACT []
synonym: "GPI anchor synthesis" EXACT []
synonym: "GPI/GSI anchor biosynthesis" BROAD []
synonym: "GPI/GSI anchor biosynthetic process" BROAD []
is_a: GO:0006505 ! GPI anchor metabolic process
is_a: GO:0006661 ! phosphatidylinositol biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
relationship: part_of GO:0180046 ! GPI anchored protein biosynthesis

[Term]
id: GO:0006507
name: obsolete GPI anchor release
namespace: biological_process
def: "OBSOLETE. The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." [GOC:mah, PMID:18811934]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
consider: GO:0004621

[Term]
id: GO:0006508
name: proteolysis
namespace: biological_process
def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
synonym: "ATP-dependent proteolysis" NARROW [GOC:mah]
synonym: "peptidolysis" EXACT []
xref: Wikipedia:Proteolysis
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0006509
name: membrane protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, PMID:24227200]
synonym: "ectoderm shedding" BROAD [GOC:pm, PMID:12096138, PMID:15672459, PMID:18419754]
synonym: "ectodomain cleavage" EXACT [PMID:18757500]
synonym: "membrane protein solubilization" RELATED []
synonym: "receptor shedding" RELATED []
is_a: GO:0033619 ! membrane protein proteolysis

[Term]
id: GO:0006510
name: obsolete ATP-dependent proteolysis
namespace: biological_process
def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function.
synonym: "ATP-dependent peptidolysis" EXACT []
synonym: "ATP-dependent proteolysis" EXACT []
is_obsolete: true
replaced_by: GO:0004176
consider: GO:0006508
consider: GO:0016485
consider: GO:0051603

[Term]
id: GO:0006511
name: ubiquitin-dependent protein catabolic process
namespace: biological_process
alt_id: GO:0042787
alt_id: GO:0043432
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW []
synonym: "protein degradation tagging activity" BROAD []
synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW []
synonym: "protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW []
synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" NARROW []
synonym: "protein ubiquitination involved in ubiquitin-dependent protein catabolic process" RELATED []
synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW []
synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW []
synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW []
synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW []
synonym: "ubiquitin-dependent protein breakdown" EXACT []
synonym: "ubiquitin-dependent protein catabolism" EXACT []
synonym: "ubiquitin-dependent protein degradation" EXACT []
synonym: "ubiquitin-dependent proteolysis" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0006512
name: obsolete ubiquitin cycle
namespace: biological_process
def: "OBSOLETE. The cyclical process by which one or more ubiquitin groups are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093]
comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers.
synonym: "ubiquitin cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0006513
name: protein monoubiquitination
namespace: biological_process
def: "Addition of a single ubiquitin group to a protein." [GOC:ai]
synonym: "protein monoubiquitinylation" EXACT []
synonym: "protein monoubiquitylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0006515
name: protein quality control for misfolded or incompletely synthesized proteins
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]
synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT []
synonym: "misfolded or incompletely synthesized protein breakdown" EXACT []
synonym: "misfolded or incompletely synthesized protein catabolic process" EXACT []
synonym: "misfolded or incompletely synthesized protein catabolism" EXACT []
synonym: "misfolded or incompletely synthesized protein degradation" EXACT []
synonym: "protein quality control (PQC)" EXACT []
synonym: "protein quality control by the ubiquitin-proteasome system" BROAD []
is_a: GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:0006516
name: glycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
synonym: "glycoprotein breakdown" EXACT []
synonym: "glycoprotein catabolism" EXACT []
synonym: "glycoprotein degradation" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:0030163 ! protein catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0006517
name: protein deglycosylation
namespace: biological_process
def: "The removal of sugar residues from a glycosylated protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "glycoprotein deglycosylation" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0006518
name: peptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]
subset: goslim_pir
synonym: "peptide metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006520
name: amino acid metabolic process
namespace: biological_process
alt_id: GO:0006519
def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "amino acid and derivative metabolism" RELATED []
synonym: "cellular amino acid and derivative metabolic process" RELATED []
synonym: "cellular amino acid metabolic process" EXACT []
synonym: "cellular amino acid metabolism" EXACT []
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0006521
name: regulation of amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators]
synonym: "regulation of amino acid metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0006522
name: alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators]
synonym: "alanine metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006523
name: alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators]
synonym: "alanine anabolism" EXACT []
synonym: "alanine biosynthesis" EXACT []
synonym: "alanine formation" EXACT []
synonym: "alanine synthesis" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0006524
name: alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators]
synonym: "alanine breakdown" EXACT []
synonym: "alanine catabolism" EXACT []
synonym: "alanine degradation" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006525
name: arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]
synonym: "arginine metabolism" EXACT []
xref: Wikipedia:Arginine
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006526
name: L-arginine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ISBN:0198506732]
synonym: "arginine anabolism" EXACT []
synonym: "arginine biosynthesis" EXACT []
synonym: "arginine formation" EXACT []
synonym: "arginine synthesis" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006527
name: arginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]
synonym: "arginine breakdown" EXACT []
synonym: "arginine catabolism" EXACT []
synonym: "arginine degradation" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006528
name: asparagine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
synonym: "asparagine metabolism" EXACT []
xref: MetaCyc:ASPARAGINESYN-PWY
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006529
name: asparagine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
synonym: "asparagine anabolism" EXACT []
synonym: "asparagine biosynthesis" EXACT []
synonym: "asparagine formation" EXACT []
synonym: "asparagine synthesis" EXACT []
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0006530
name: asparagine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
synonym: "asparagine breakdown" EXACT []
synonym: "asparagine catabolism" EXACT []
synonym: "asparagine degradation" EXACT []
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006531
name: aspartate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732]
synonym: "aspartate metabolism" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006532
name: aspartate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732]
synonym: "aspartate anabolism" EXACT []
synonym: "aspartate biosynthesis" EXACT []
synonym: "aspartate formation" EXACT []
synonym: "aspartate synthesis" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0006533
name: aspartate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732]
synonym: "aspartate breakdown" EXACT []
synonym: "aspartate catabolism" EXACT []
synonym: "aspartate degradation" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0006534
name: cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
synonym: "cysteine metabolism" EXACT []
xref: Wikipedia:Cysteine_metabolism
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006535
name: cysteine biosynthetic process from serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]
synonym: "cysteine anabolism from serine" EXACT []
synonym: "cysteine formation from serine" EXACT []
synonym: "cysteine synthesis from serine" EXACT []
xref: MetaCyc:CYSTSYN-PWY
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0006536
name: glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
synonym: "glutamate metabolism" EXACT []
synonym: "glutamic acid metabolic process" EXACT []
synonym: "glutamic acid metabolism" EXACT []
xref: Wikipedia:Glutamic_acid
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006537
name: glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
synonym: "glutamate anabolism" EXACT []
synonym: "glutamate biosynthesis" EXACT []
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate formation" EXACT []
synonym: "glutamate synthesis" EXACT []
synonym: "glutamic acid biosynthesis" EXACT []
synonym: "glutamic acid biosynthetic process" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0006538
name: glutamate catabolic process
namespace: biological_process
alt_id: GO:0019459
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
synonym: "glutamate breakdown" EXACT []
synonym: "glutamate catabolism" EXACT []
synonym: "glutamate deamidation" RELATED []
synonym: "glutamate degradation" EXACT []
synonym: "glutamic acid catabolic process" EXACT []
synonym: "glutamic acid catabolism" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0006539
name: obsolete glutamate catabolic process via 2-oxoglutarate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators]
comment: The reason for obsoletion is that this term is equivalent to GO:0019552 glutamate catabolic process via 2-hydroxyglutarate, XREF the same MetaCyc pathway.
synonym: "glutamate breakdown via 2-oxoglutarate" EXACT []
synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT []
synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT []
synonym: "glutamate catabolism via 2-ketoglutarate" EXACT []
synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT []
synonym: "glutamate degradation via 2-oxoglutarate" EXACT []
is_obsolete: true
replaced_by: GO:0019552

[Term]
id: GO:0006540
name: gamma-aminobutyrate shunt
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438]
comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
synonym: "4-aminobutyrate shunt" EXACT []
synonym: "degradation of glutamate to succinate through GABA" EXACT [MetaCyc:GLUDEG-I-PWY]
synonym: "GABA shunt" EXACT []
synonym: "gamma aminobutyrate shunt" EXACT []
synonym: "glutamate decarboxylation to succinate" EXACT []
synonym: "glutamate degradation via 4-aminobutyrate" EXACT [MetaCyc:GLUDEG-I-PWY]
synonym: "glutamate degradation via GABA" EXACT [MetaCyc:GLUDEG-I-PWY]
xref: MetaCyc:GLUDEG-I-PWY
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0006541
name: glutamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
synonym: "glutamine metabolism" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0006542
name: glutamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
synonym: "glutamine anabolism" EXACT []
synonym: "glutamine biosynthesis" EXACT []
synonym: "glutamine formation" EXACT []
synonym: "glutamine synthesis" EXACT []
xref: MetaCyc:GLNSYN-PWY
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006543
name: glutamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
synonym: "glutamine breakdown" EXACT []
synonym: "glutamine catabolism" EXACT []
synonym: "glutamine degradation" EXACT []
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006544
name: glycine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]
synonym: "glycine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006545
name: glycine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]
synonym: "glycine anabolism" EXACT []
synonym: "glycine biosynthesis" EXACT []
synonym: "glycine formation" EXACT []
synonym: "glycine synthesis" EXACT []
xref: MetaCyc:GLYCINE-SYN2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0006546
name: glycine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
synonym: "glycine breakdown" EXACT []
synonym: "glycine catabolism" EXACT []
synonym: "glycine degradation" EXACT []
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0006547
name: L-histidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
synonym: "histidine metabolic process" BROAD []
synonym: "histidine metabolism" EXACT []
xref: Wikipedia:Histidine
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0006548
name: L-histidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
synonym: "histidine breakdown" EXACT []
synonym: "histidine catabolic process" BROAD []
synonym: "histidine catabolism" EXACT []
synonym: "histidine degradation" EXACT []
is_a: GO:0006547 ! L-histidine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0052805 ! imidazole-containing compound catabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process

[Term]
id: GO:0006549
name: isoleucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
synonym: "isoleucine metabolism" EXACT []
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006550
name: isoleucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
synonym: "isoleucine breakdown" EXACT []
synonym: "isoleucine catabolism" EXACT []
synonym: "isoleucine degradation" EXACT []
xref: MetaCyc:ILEUDEG-PWY
is_a: GO:0006549 ! isoleucine metabolic process
is_a: GO:0009083 ! branched-chain amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006551
name: L-leucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
synonym: "L-leucine metabolism" EXACT []
synonym: "leucine metabolic process" BROAD []
is_a: GO:0009078 ! pyruvate family amino acid metabolic process
is_a: GO:0009081 ! branched-chain amino acid metabolic process

[Term]
id: GO:0006552
name: L-leucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
synonym: "L-leucine breakdown" EXACT []
synonym: "L-leucine catabolism" EXACT []
synonym: "L-leucine degradation" EXACT []
synonym: "leucine catabolic process" BROAD []
xref: MetaCyc:LEU-DEG2-PWY
is_a: GO:0006551 ! L-leucine metabolic process
is_a: GO:0009080 ! pyruvate family amino acid catabolic process
is_a: GO:0009083 ! branched-chain amino acid catabolic process

[Term]
id: GO:0006553
name: lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
synonym: "lysine metabolism" EXACT []
xref: Wikipedia:Lysine
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006554
name: lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
synonym: "lysine breakdown" EXACT []
synonym: "lysine catabolism" EXACT []
synonym: "lysine degradation" EXACT []
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006555
name: methionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "methionine and threonine metabolic process" BROAD []
synonym: "methionine and threonine metabolism" BROAD []
synonym: "methionine metabolism" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006556
name: S-adenosylmethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]
synonym: "S-adenosyl methionine biosynthesis" EXACT []
synonym: "S-adenosyl methionine biosynthetic process" EXACT []
synonym: "S-adenosylmethionine anabolism" EXACT []
synonym: "S-adenosylmethionine biosynthesis" EXACT []
synonym: "S-adenosylmethionine formation" EXACT []
synonym: "S-adenosylmethionine synthesis" EXACT []
synonym: "SAM biosynthetic process" EXACT []
xref: MetaCyc:SAM-PWY
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process

[Term]
id: GO:0006557
name: obsolete S-adenosylmethioninamine biosynthetic process
namespace: biological_process
alt_id: GO:0006745
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]
comment: This term was obsoleted because it represents a molecular function.
synonym: "S-adenosylmethioninamine anabolism" EXACT []
synonym: "S-adenosylmethioninamine biosynthesis" EXACT []
synonym: "S-adenosylmethioninamine formation" EXACT []
synonym: "S-adenosylmethioninamine synthesis" EXACT []
is_obsolete: true
consider: GO:0004014

[Term]
id: GO:0006558
name: L-phenylalanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [GOC:jsg, GOC:mah]
synonym: "L-phenylalanine metabolism" EXACT []
synonym: "phenylalanine metabolic process" BROAD []
synonym: "phenylalanine metabolism" BROAD []
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

[Term]
id: GO:0006559
name: L-phenylalanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]
synonym: "L-phenylalanine breakdown" EXACT []
synonym: "L-phenylalanine catabolism" EXACT []
synonym: "L-phenylalanine degradation" EXACT []
synonym: "phenylalanine catabolic process" BROAD []
synonym: "phenylalanine catabolism" BROAD []
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process

[Term]
id: GO:0006560
name: proline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "proline metabolism" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0006561
name: proline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]
synonym: "proline anabolism" EXACT []
synonym: "proline biosynthesis" EXACT []
synonym: "proline formation" EXACT []
synonym: "proline synthesis" EXACT []
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006562
name: proline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "proline breakdown" EXACT []
synonym: "proline catabolism" EXACT []
synonym: "proline degradation" EXACT []
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006563
name: L-serine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]
synonym: "L-serine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006564
name: L-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]
synonym: "L-serine anabolism" EXACT []
synonym: "L-serine biosynthesis" EXACT []
synonym: "L-serine formation" EXACT []
synonym: "L-serine synthesis" EXACT []
xref: MetaCyc:SERSYN-PWY
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0006565
name: L-serine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]
synonym: "L-serine breakdown" EXACT []
synonym: "L-serine catabolism" EXACT []
synonym: "L-serine degradation" EXACT []
xref: MetaCyc:SERDEG-PWY
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0006566
name: threonine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "methionine and threonine metabolic process" BROAD []
synonym: "methionine and threonine metabolism" BROAD []
synonym: "threonine metabolism" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006567
name: threonine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "threonine breakdown" EXACT []
synonym: "threonine catabolism" EXACT []
synonym: "threonine degradation" EXACT []
xref: MetaCyc:THREOCAT-PWY
xref: UM-BBD_pathwayID:met
is_a: GO:0006566 ! threonine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006568
name: tryptophan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
synonym: "tryptophan metabolism" EXACT []
xref: Wikipedia:Tryptophan
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

[Term]
id: GO:0006569
name: tryptophan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
synonym: "tryptophan breakdown" EXACT []
synonym: "tryptophan catabolic process, using tryptophanase" NARROW []
synonym: "tryptophan catabolism" EXACT []
synonym: "tryptophan catabolism, using tryptophanase" NARROW []
synonym: "tryptophan degradation" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006570
name: tyrosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]
synonym: "tyrosine metabolism" EXACT []
xref: UM-BBD_pathwayID:tyr
xref: Wikipedia:Tyrosine
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

[Term]
id: GO:0006571
name: tyrosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm]
synonym: "tyrosine anabolism" EXACT []
synonym: "tyrosine biosynthesis" EXACT []
synonym: "tyrosine formation" EXACT []
synonym: "tyrosine synthesis" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway
is_a: GO:1902223 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process

[Term]
id: GO:0006572
name: tyrosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]
synonym: "tyrosine breakdown" EXACT []
synonym: "tyrosine catabolism" EXACT []
synonym: "tyrosine degradation" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process

[Term]
id: GO:0006573
name: valine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
synonym: "valine metabolism" EXACT []
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006574
name: valine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
synonym: "valine breakdown" EXACT []
synonym: "valine catabolism" EXACT []
synonym: "valine degradation" EXACT []
xref: MetaCyc:VALDEG-PWY
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0009083 ! branched-chain amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006575
name: modified amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
synonym: "amino acid derivative metabolic process" EXACT []
synonym: "cellular amino acid derivative metabolic process" EXACT []
synonym: "cellular amino acid derivative metabolism" EXACT []
synonym: "cellular modified amino acid metabolic process" EXACT [GOC:mah]
synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah]
synonym: "modified amino acid metabolism" EXACT [GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006576
name: biogenic amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
synonym: "biogenic amine metabolism" EXACT []
synonym: "cellular biogenic amine metabolic process" EXACT []
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0006577
name: amino-acid betaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732]
synonym: "betaine metabolic process" EXACT []
synonym: "betaine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process

[Term]
id: GO:0006578
name: amino-acid betaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732]
synonym: "betaine anabolism" EXACT []
synonym: "betaine biosynthesis" EXACT []
synonym: "betaine biosynthetic process" EXACT []
synonym: "betaine formation" EXACT []
synonym: "betaine synthesis" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process

[Term]
id: GO:0006579
name: amino-acid betaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732]
synonym: "betaine breakdown" EXACT []
synonym: "betaine catabolic process" EXACT []
synonym: "betaine catabolism" EXACT []
synonym: "betaine degradation" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process

[Term]
id: GO:0006580
name: ethanolamine metabolic process
namespace: biological_process
alt_id: GO:0006645
def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [ISBN:0192800981]
synonym: "ethanolamine metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0006581
name: acetylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine breakdown" EXACT []
synonym: "acetylcholine catabolism" EXACT []
synonym: "acetylcholine degradation" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0006582
name: melanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators]
synonym: "melanin metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0006583
name: melanin biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
synonym: "melanin anabolism from tyrosine" EXACT []
synonym: "melanin formation from tyrosine" EXACT []
synonym: "melanin synthesis from tyrosine" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0006584
name: catecholamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine metabolism" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process

[Term]
id: GO:0006585
name: dopamine biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732]
synonym: "dopamine anabolism from tyrosine" EXACT []
synonym: "dopamine formation from tyrosine" EXACT []
synonym: "dopamine synthesis from tyrosine" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0042416 ! dopamine biosynthetic process

[Term]
id: GO:0006586
name: indolalkylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators]
synonym: "indolalkylamine metabolism" EXACT []
synonym: "indolamine metabolic process" BROAD []
synonym: "indolamine metabolism" BROAD []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0006587
name: serotonin biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin anabolism from tryptophan" EXACT []
synonym: "serotonin formation from tryptophan" EXACT []
synonym: "serotonin synthesis from tryptophan" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0042427 ! serotonin biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006588
name: obsolete activation of tryptophan 5-monooxygenase activity
namespace: biological_process
def: "OBSOLETE. The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0006589
name: octopamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
synonym: "octopamine anabolism" EXACT []
synonym: "octopamine biosynthesis" EXACT []
synonym: "octopamine formation" EXACT []
synonym: "octopamine synthesis" EXACT []
is_a: GO:0042401 ! biogenic amine biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0046333 ! octopamine metabolic process

[Term]
id: GO:0006590
name: thyroid hormone generation
namespace: biological_process
def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094]
comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.
is_a: GO:0042403 ! thyroid hormone metabolic process

[Term]
id: GO:0006591
name: ornithine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
synonym: "ornithine metabolism" EXACT []
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006592
name: ornithine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
synonym: "ornithine anabolism" EXACT []
synonym: "ornithine biosynthesis" EXACT []
synonym: "ornithine formation" EXACT []
synonym: "ornithine synthesis" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0006593
name: ornithine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
synonym: "ornithine breakdown" EXACT []
synonym: "ornithine catabolism" EXACT []
synonym: "ornithine degradation" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006595
name: polyamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
subset: goslim_drosophila
synonym: "polyamine metabolism" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process

[Term]
id: GO:0006596
name: polyamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
synonym: "polyamine anabolism" EXACT []
synonym: "polyamine biosynthesis" EXACT []
synonym: "polyamine formation" EXACT []
synonym: "polyamine synthesis" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0042401 ! biogenic amine biosynthetic process

[Term]
id: GO:0006597
name: spermine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [GOC:curators]
synonym: "spermine anabolism" EXACT []
synonym: "spermine biosynthesis" EXACT []
synonym: "spermine formation" EXACT []
synonym: "spermine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0006598
name: polyamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
synonym: "polyamine breakdown" EXACT []
synonym: "polyamine catabolism" EXACT []
synonym: "polyamine degradation" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0042402 ! biogenic amine catabolic process

[Term]
id: GO:0006599
name: phosphagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]
synonym: "phosphagen metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0006600
name: creatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023]
synonym: "creatine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006601
name: creatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [GOC:mah, MetaCyc:GLYCGREAT-PWY]
synonym: "creatine anabolism" EXACT []
synonym: "creatine biosynthesis" EXACT []
synonym: "creatine formation" EXACT []
synonym: "creatine synthesis" EXACT []
xref: MetaCyc:GLYCGREAT-PWY
is_a: GO:0006600 ! creatine metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0006602
name: creatinine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732]
synonym: "creatinine breakdown" EXACT []
synonym: "creatinine catabolism" EXACT []
synonym: "creatinine degradation" EXACT []
is_a: GO:0046449 ! creatinine metabolic process
is_a: GO:0072340 ! lactam catabolic process

[Term]
id: GO:0006603
name: phosphocreatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [PMID:16371597]
synonym: "phosphocreatine metabolism" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process

[Term]
id: GO:0006604
name: phosphoarginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [GOC:curators, PMID:16371597]
synonym: "phosphoarginine metabolism" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0006605
name: protein targeting
namespace: biological_process
def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]
subset: goslim_chembl
subset: goslim_pombe
subset: goslim_yeast
synonym: "nascent polypeptide association" RELATED []
synonym: "protein sorting along secretory pathway" NARROW []
xref: Wikipedia:Protein_targeting
is_a: GO:0045184 ! establishment of protein localization

[Term]
id: GO:0006606
name: protein import into nucleus
namespace: biological_process
def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah]
synonym: "protein import into cell nucleus" EXACT []
synonym: "protein nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:0051170 ! import into nucleus
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0006607
name: NLS-bearing protein import into nucleus
namespace: biological_process
def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai]
synonym: "NLS-bearing substrate import into cell nucleus" EXACT []
synonym: "NLS-bearing substrate import into nucleus" EXACT [GOC:bf, GOC:jl]
synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT []
synonym: "NLS-bearing substrate-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006608
name: obsolete snRNP protein import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "snRNP protein import into cell nucleus" EXACT []
synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT []
synonym: "snRNP protein-nucleus import" EXACT []
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0006609
name: obsolete mRNA-binding (hnRNP) protein import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a heterogeneous nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT []
synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT []
synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT []
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0006610
name: ribosomal protein import into nucleus
namespace: biological_process
def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus." [GOC:ai, PMID:11809816]
comment: Ribosomal protein rpl12 uses a different import pathway, which is why it has a separate GO term.
synonym: "ribosomal protein import into cell nucleus" EXACT []
synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT []
synonym: "ribosomal protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006611
name: protein export from nucleus
namespace: biological_process
alt_id: GO:0097349
def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
synonym: "copper-induced protein export from nucleus" RELATED [GOC:al]
synonym: "protein export from cell nucleus" EXACT []
synonym: "protein export out of nucleus" EXACT []
synonym: "protein transport from nucleus to cytoplasm" EXACT []
synonym: "protein-nucleus export" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0051168 ! nuclear export

[Term]
id: GO:0006612
name: protein targeting to membrane
namespace: biological_process
def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]
synonym: "protein membrane targeting" EXACT []
synonym: "protein-membrane targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0006613
name: cotranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215]
synonym: "cotranslational membrane targeting" EXACT []
synonym: "cotranslational protein membrane targeting" EXACT []
synonym: "cotranslational protein-membrane targeting" EXACT []
is_a: GO:0006612 ! protein targeting to membrane

[Term]
id: GO:0006614
name: SRP-dependent cotranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]
synonym: "ER translocation" BROAD []
synonym: "SRP-dependent cotranslational membrane targeting" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT []
is_a: GO:0006613 ! cotranslational protein targeting to membrane
is_a: GO:0045047 ! protein targeting to ER

[Term]
id: GO:0006615
name: SRP-dependent cotranslational protein targeting to membrane, docking
namespace: biological_process
def: "The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT []
is_a: GO:0022615 ! protein to membrane docking
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006616
name: SRP-dependent cotranslational protein targeting to membrane, translocation
namespace: biological_process
def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363]
synonym: "ER translocation" BROAD []
synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT []
synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006617
name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
namespace: biological_process
def: "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006618
name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing
namespace: biological_process
def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT []
is_a: GO:0006465 ! signal peptide processing
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006619
name: obsolete SRP-independent cotranslational protein-membrane targeting
namespace: biological_process
def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "ER translocation" BROAD []
synonym: "SRP-independent cotranslational membrane targeting" EXACT []
synonym: "SRP-independent cotranslational protein-membrane targeting" EXACT []
is_obsolete: true

[Term]
id: GO:0006620
name: post-translational protein targeting to endoplasmic reticulum membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363]
synonym: "posttranslational endoplasmic reticulum membrane targeting" EXACT []
synonym: "posttranslational endoplasmic reticulum protein-membrane targeting" EXACT []
synonym: "posttranslational protein endoplasmic reticulum membrane targeting" EXACT []
synonym: "posttranslational protein targeting to endoplasmic reticulum membrane" EXACT []
synonym: "posttranslational protein targeting to ER membrane" EXACT []
synonym: "SRP-independent endoplasmic reticulum protein-membrane targeting" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0045047 ! protein targeting to ER

[Term]
id: GO:0006621
name: protein retention in ER lumen
namespace: biological_process
def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]
synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb]
is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum

[Term]
id: GO:0006622
name: protein targeting to lysosome
namespace: biological_process
def: "The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators]
synonym: "protein-lysosome targeting" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0061462 ! protein localization to lysosome

[Term]
id: GO:0006623
name: protein targeting to vacuole
namespace: biological_process
def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]
synonym: "protein vacuolar targeting" EXACT []
synonym: "protein-vacuolar targeting" EXACT []
synonym: "protein-vacuole targeting" EXACT []
synonym: "vacuolar protein sorting" EXACT [GOC:vw]
is_a: GO:0006605 ! protein targeting
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0072666 ! establishment of protein localization to vacuole

[Term]
id: GO:0006624
name: vacuolar protein processing
namespace: biological_process
def: "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." [GOC:mah]
synonym: "vacuolar protein maturation" RELATED []
synonym: "vacuolar proteolysis" RELATED []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0006625
name: protein targeting to peroxisome
namespace: biological_process
def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]
synonym: "protein-peroxisome targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0072663 ! establishment of protein localization to peroxisome

[Term]
id: GO:0006626
name: protein targeting to mitochondrion
namespace: biological_process
alt_id: GO:0043681
def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]
synonym: "mitochondrial protein import" RELATED []
synonym: "mitochondrial translocation" RELATED []
synonym: "protein import into mitochondrion" EXACT []
synonym: "protein targeting to mitochondria" EXACT []
synonym: "protein-mitochondrial targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0072655 ! establishment of protein localization to mitochondrion

[Term]
id: GO:0006627
name: protein processing involved in protein targeting to mitochondrion
namespace: biological_process
def: "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]
synonym: "mitochondrial processing" BROAD []
synonym: "mitochondrial protein processing during import" RELATED [GOC:dph, GOC:tb]
is_a: GO:0034982 ! mitochondrial protein processing
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0006628
name: obsolete mitochondrial translocation
namespace: biological_process
def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576]
comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation.
synonym: "mitochondrial translocation" EXACT []
is_obsolete: true
consider: GO:0006626

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "lipid metabolism" EXACT []
xref: Wikipedia:Lipid_metabolism
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0006630
name: obsolete lipid binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "lipid binding" EXACT []
is_obsolete: true
consider: GO:0008289

[Term]
id: GO:0006631
name: fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]
synonym: "fatty acid metabolism" EXACT []
xref: Wikipedia:Fatty_acid_metabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006633
name: fatty acid biosynthetic process
namespace: biological_process
alt_id: GO:0000037
def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
synonym: "fatty acid anabolism" EXACT []
synonym: "fatty acid biosynthesis" EXACT []
synonym: "fatty acid formation" EXACT []
synonym: "fatty acid synthesis" EXACT []
xref: Wikipedia:Fatty_acid_synthesis
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0006634
name: hexadecanal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [https://en.wikipedia.org/wiki/Hexadecanal]
synonym: "hexadecanal anabolism" EXACT []
synonym: "hexadecanal biosynthesis" EXACT []
synonym: "hexadecanal formation" EXACT []
synonym: "hexadecanal synthesis" EXACT []
synonym: "palmitaldehyde biosynthesis" EXACT []
synonym: "palmitaldehyde biosynthetic process" EXACT []
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046458 ! hexadecanal metabolic process

[Term]
id: GO:0006635
name: fatty acid beta-oxidation
namespace: biological_process
def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732]
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0006636
name: unsaturated fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]
synonym: "fatty acid desaturation" RELATED []
synonym: "polyunsaturated fatty acid biosynthesis" NARROW [GOC:yaf, MetaCyc:PWY-762]
synonym: "unsaturated fatty acid anabolism" EXACT []
synonym: "unsaturated fatty acid biosynthesis" EXACT []
synonym: "unsaturated fatty acid formation" EXACT []
synonym: "unsaturated fatty acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0006637
name: acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]
synonym: "acyl-CoA metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:0035383 ! thioester metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0006638
name: neutral lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684]
synonym: "neutral lipid metabolism" EXACT []
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0006639
name: acylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732]
synonym: "acylglycerol metabolism" EXACT []
synonym: "glyceride metabolic process" EXACT []
synonym: "glyceride metabolism" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0006640
name: monoacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732]
synonym: "monoacylglycerol anabolism" EXACT []
synonym: "monoacylglycerol biosynthesis" EXACT []
synonym: "monoacylglycerol formation" EXACT []
synonym: "monoacylglycerol synthesis" EXACT []
synonym: "monoglyceride biosynthesis" EXACT []
synonym: "monoglyceride biosynthetic process" EXACT []
is_a: GO:0046462 ! monoacylglycerol metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0006641
name: triglyceride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
synonym: "triacylglycerol metabolic process" EXACT []
synonym: "triacylglycerol metabolism" EXACT []
synonym: "triglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0006642
name: triglyceride mobilization
namespace: biological_process
def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625]
synonym: "triacylglycerol mobilization" EXACT []
is_a: GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0006643
name: membrane lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
synonym: "membrane lipid metabolism" EXACT []
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0006644
name: phospholipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
synonym: "phospholipid metabolism" EXACT []
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0006646
name: phosphatidylethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
synonym: "phosphatidylethanolamine anabolism" EXACT []
synonym: "phosphatidylethanolamine biosynthesis" EXACT []
synonym: "phosphatidylethanolamine formation" EXACT []
synonym: "phosphatidylethanolamine synthesis" EXACT []
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006647
name: phosphatidyl-N-monomethylethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai]
synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT []
synonym: "PMME biosynthesis" EXACT []
synonym: "PMME biosynthetic process" EXACT []
is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process
is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process

[Term]
id: GO:0006648
name: dihydrosphingosine-1-P pathway
namespace: biological_process
def: "A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase." [GOC:mah, PMID:15643073]
is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process

[Term]
id: GO:0006649
name: phospholipid transfer to membrane
namespace: biological_process
def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators]
is_a: GO:0015914 ! phospholipid transport
relationship: part_of GO:0061024 ! membrane organization

[Term]
id: GO:0006650
name: glycerophospholipid metabolic process
namespace: biological_process
alt_id: GO:0006652
def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
synonym: "alpha-glycerophosphate pathway" RELATED []
synonym: "glycerophospholipid metabolism" EXACT []
synonym: "phosphoglyceride metabolic process" EXACT []
synonym: "phosphoglyceride metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0006651
name: diacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [GOC:curators]
synonym: "diacylglycerol anabolism" EXACT []
synonym: "diacylglycerol biosynthesis" EXACT []
synonym: "diacylglycerol formation" EXACT []
synonym: "diacylglycerol synthesis" EXACT []
synonym: "diglyceride biosynthesis" EXACT []
is_a: GO:0046339 ! diacylglycerol metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0006653
name: 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [ISBN:0198506732]
synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah]
synonym: "lecithin metabolic process" BROAD []
is_a: GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0006654
name: phosphatidic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]
synonym: "phosphatidic acid anabolism" EXACT []
synonym: "phosphatidic acid biosynthesis" EXACT []
synonym: "phosphatidic acid formation" EXACT []
synonym: "phosphatidic acid synthesis" EXACT []
is_a: GO:0046473 ! phosphatidic acid metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006655
name: phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732]
synonym: "phosphatidylglycerol anabolism" EXACT []
synonym: "phosphatidylglycerol biosynthesis" EXACT []
synonym: "phosphatidylglycerol formation" EXACT []
synonym: "phosphatidylglycerol synthesis" EXACT []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006656
name: phosphatidylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732]
synonym: "phosphatidylcholine anabolism" EXACT []
synonym: "phosphatidylcholine biosynthesis" EXACT []
synonym: "phosphatidylcholine formation" EXACT []
synonym: "phosphatidylcholine synthesis" EXACT []
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006657
name: CDP-choline pathway
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]
synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450]
synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450]
xref: MetaCyc:PWY3O-450
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0006658
name: phosphatidylserine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]
synonym: "phosphatidylserine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0006659
name: phosphatidylserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732]
synonym: "phosphatidylserine anabolism" EXACT []
synonym: "phosphatidylserine biosynthesis" EXACT []
synonym: "phosphatidylserine formation" EXACT []
synonym: "phosphatidylserine synthesis" EXACT []
is_a: GO:0006658 ! phosphatidylserine metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006660
name: phosphatidylserine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732]
synonym: "phosphatidylserine breakdown" EXACT []
synonym: "phosphatidylserine catabolism" EXACT []
synonym: "phosphatidylserine degradation" EXACT []
is_a: GO:0006658 ! phosphatidylserine metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0006661
name: phosphatidylinositol biosynthetic process
namespace: biological_process
alt_id: GO:0046489
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]
synonym: "phosphatidylinositol anabolism" EXACT []
synonym: "phosphatidylinositol biosynthesis" EXACT []
synonym: "phosphatidylinositol formation" EXACT []
synonym: "phosphatidylinositol synthesis" EXACT []
synonym: "phosphoinositide biosynthesis" EXACT []
synonym: "phosphoinositide biosynthetic process" EXACT []
synonym: "PtdIns biosynthesis" EXACT []
synonym: "PtdIns biosynthetic process" EXACT []
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0006662
name: glycerol ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
synonym: "glycerol ether metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:0006663
name: platelet activating factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684]
synonym: "PAF biosynthesis" EXACT []
synonym: "PAF biosynthetic process" EXACT []
synonym: "platelet activating factor anabolism" EXACT []
synonym: "platelet activating factor biosynthesis" EXACT []
synonym: "platelet activating factor formation" EXACT []
synonym: "platelet activating factor synthesis" EXACT []
is_a: GO:0008611 ! ether lipid biosynthetic process
is_a: GO:0046469 ! platelet activating factor metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006664
name: glycolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." [ISBN:0198547684]
synonym: "glycolipid metabolism" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:1903509 ! liposaccharide metabolic process

[Term]
id: GO:0006665
name: sphingolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
synonym: "sphingolipid metabolism" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process

[Term]
id: GO:0006666
name: 3-keto-sphinganine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai]
synonym: "3-keto-dihydrosphingosine metabolic process" EXACT []
synonym: "3-keto-dihydrosphingosine metabolism" EXACT []
synonym: "3-keto-sphinganine metabolism" EXACT []
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006667
name: sphinganine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [PMID:29165427]
synonym: "dihydrosphingosine metabolic process" EXACT []
synonym: "dihydrosphingosine metabolism" EXACT []
synonym: "sphinganine metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006668
name: sphinganine-1-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT []
synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT []
synonym: "sphinganine-1-phosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006669
name: sphinganine-1-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT []
synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT []
synonym: "sphinganine-1-phosphate anabolism" EXACT []
synonym: "sphinganine-1-phosphate biosynthesis" EXACT []
synonym: "sphinganine-1-phosphate formation" EXACT []
synonym: "sphinganine-1-phosphate synthesis" EXACT []
is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0006670
name: sphingosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732]
synonym: "(4E)-sphing-4-enine metabolic process" EXACT []
synonym: "(4E)-sphing-4-enine metabolism" EXACT []
synonym: "sphing-4-enine metabolic process" EXACT []
synonym: "sphing-4-enine metabolism" EXACT []
synonym: "sphingosine metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006671
name: phytosphingosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [ISBN:0198506732]
synonym: "phytosphingosine metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006672
name: ceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]
synonym: "ceramide metabolism" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0006673
name: inositol phosphoceramide metabolic process
namespace: biological_process
alt_id: GO:0006674
def: "The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group." [PMID:19726565]
synonym: "inositol phosphorylceramide metabolic process" EXACT []
synonym: "inositol phosphorylceramide metabolism" EXACT []
synonym: "inositolphosphoceramide metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006675
name: mannosyl-inositol phosphorylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai]
synonym: "mannose inositol phosphoceramide metabolic process" EXACT []
synonym: "mannose inositol phosphoceramide metabolism" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT []
synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT []
synonym: "MIPC metabolic process" EXACT []
synonym: "MIPC metabolism" EXACT []
is_a: GO:0006673 ! inositol phosphoceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0006676
name: mannosyl diphosphorylinositol ceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai]
synonym: "M(IP)2C metabolic process" EXACT []
synonym: "M(IP)2C metabolism" EXACT []
synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT []
is_a: GO:0006505 ! GPI anchor metabolic process
is_a: GO:0006673 ! inositol phosphoceramide metabolic process

[Term]
id: GO:0006677
name: glycosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732]
synonym: "glycosylceramide metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0006678
name: glucosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [ISBN:0198506732]
synonym: "glucosylceramide metabolism" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process

[Term]
id: GO:0006679
name: glucosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]
synonym: "glucosylceramide anabolism" EXACT []
synonym: "glucosylceramide biosynthesis" EXACT []
synonym: "glucosylceramide formation" EXACT []
synonym: "glucosylceramide synthesis" EXACT []
is_a: GO:0006678 ! glucosylceramide metabolic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process

[Term]
id: GO:0006680
name: glucosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]
synonym: "glucosylceramide breakdown" EXACT []
synonym: "glucosylceramide catabolism" EXACT []
synonym: "glucosylceramide degradation" EXACT []
is_a: GO:0006678 ! glucosylceramide metabolic process
is_a: GO:0046477 ! glycosylceramide catabolic process

[Term]
id: GO:0006681
name: galactosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
synonym: "galactosylceramide metabolism" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0019374 ! galactolipid metabolic process

[Term]
id: GO:0006682
name: galactosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
synonym: "galactosylceramide anabolism" EXACT []
synonym: "galactosylceramide biosynthesis" EXACT []
synonym: "galactosylceramide formation" EXACT []
synonym: "galactosylceramide synthesis" EXACT []
is_a: GO:0006681 ! galactosylceramide metabolic process
is_a: GO:0019375 ! galactolipid biosynthetic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process

[Term]
id: GO:0006683
name: galactosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
synonym: "galactosylceramide breakdown" EXACT []
synonym: "galactosylceramide catabolism" EXACT []
synonym: "galactosylceramide degradation" EXACT []
is_a: GO:0006681 ! galactosylceramide metabolic process
is_a: GO:0019376 ! galactolipid catabolic process
is_a: GO:0046477 ! glycosylceramide catabolic process

[Term]
id: GO:0006684
name: sphingomyelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732]
synonym: "sphingomyelin metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0006685
name: sphingomyelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]
synonym: "sphingomyelin breakdown" EXACT []
synonym: "sphingomyelin catabolism" EXACT []
synonym: "sphingomyelin degradation" EXACT []
is_a: GO:0006684 ! sphingomyelin metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0006686
name: sphingomyelin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]
synonym: "sphingomyelin anabolism" EXACT []
synonym: "sphingomyelin biosynthesis" EXACT []
synonym: "sphingomyelin formation" EXACT []
synonym: "sphingomyelin synthesis" EXACT []
is_a: GO:0006684 ! sphingomyelin metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0006687
name: glycosphingolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]
synonym: "glycosphingolipid metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006688
name: glycosphingolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]
synonym: "glycosphingolipid anabolism" EXACT []
synonym: "glycosphingolipid biosynthesis" EXACT []
synonym: "glycosphingolipid formation" EXACT []
synonym: "glycosphingolipid synthesis" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0006689
name: ganglioside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684]
synonym: "ganglioside breakdown" EXACT []
synonym: "ganglioside catabolism" EXACT []
synonym: "ganglioside degradation" EXACT []
is_a: GO:0001573 ! ganglioside metabolic process
is_a: GO:0046479 ! glycosphingolipid catabolic process
is_a: GO:0046514 ! ceramide catabolic process

[Term]
id: GO:0006690
name: icosanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma]
synonym: "eicosanoid metabolic process" EXACT []
synonym: "eicosanoid metabolism" EXACT []
synonym: "icosanoid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0006691
name: leukotriene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma]
synonym: "leukotriene metabolism" EXACT []
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0006692
name: prostanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732]
synonym: "prostanoid metabolism" EXACT []
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0006693
name: prostaglandin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]
synonym: "prostaglandin metabolism" EXACT []
is_a: GO:0006692 ! prostanoid metabolic process

[Term]
id: GO:0006694
name: steroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]
synonym: "steroid anabolism" EXACT []
synonym: "steroid biosynthesis" EXACT []
synonym: "steroid formation" EXACT []
synonym: "steroid synthesis" EXACT []
synonym: "steroidogenesis" EXACT []
xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0006695
name: cholesterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
synonym: "cholesterol anabolism" EXACT []
synonym: "cholesterol biosynthesis" EXACT []
synonym: "cholesterol formation" EXACT []
synonym: "cholesterol synthesis" EXACT []
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0006696
name: ergosterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732]
synonym: "ergosterol anabolism" EXACT []
synonym: "ergosterol biosynthesis" EXACT []
synonym: "ergosterol formation" EXACT []
synonym: "ergosterol synthesis" EXACT []
is_a: GO:0008204 ! ergosterol metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0016129 ! phytosteroid biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0006697
name: ecdysone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
synonym: "ecdysone anabolism" EXACT []
synonym: "ecdysone biosynthesis" EXACT []
synonym: "ecdysone formation" EXACT []
synonym: "ecdysone synthesis" EXACT []
is_a: GO:0008205 ! ecdysone metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0045456 ! ecdysteroid biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0006698
name: obsolete ecdysone modification
namespace: biological_process
def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl]
comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC:1.14.99.22) and so is a function rather than a process.
synonym: "ecdysone modification" EXACT []
is_obsolete: true
replaced_by: GO:0004501

[Term]
id: GO:0006699
name: bile acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid anabolism" EXACT []
synonym: "bile acid biosynthesis" EXACT []
synonym: "bile acid formation" EXACT []
synonym: "bile acid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0006700
name: C21-steroid hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone anabolism" EXACT []
synonym: "C21-steroid hormone biosynthesis" EXACT []
synonym: "C21-steroid hormone formation" EXACT []
synonym: "C21-steroid hormone synthesis" EXACT []
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0120178 ! steroid hormone biosynthetic process

[Term]
id: GO:0006701
name: progesterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, PMID:14613534]
synonym: "progesterone anabolism" EXACT []
synonym: "progesterone biosynthesis" EXACT []
synonym: "progesterone formation" EXACT []
synonym: "progesterone synthesis" EXACT []
is_a: GO:0006700 ! C21-steroid hormone biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0042448 ! progesterone metabolic process
is_a: GO:0120255 ! olefinic compound biosynthetic process

[Term]
id: GO:0006702
name: androgen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732]
synonym: "androgen anabolism" EXACT []
synonym: "androgen biosynthesis" EXACT []
synonym: "androgen formation" EXACT []
synonym: "androgen synthesis" EXACT []
is_a: GO:0008209 ! androgen metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0120178 ! steroid hormone biosynthetic process

[Term]
id: GO:0006703
name: estrogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]
synonym: "estrogen anabolism" EXACT []
synonym: "estrogen biosynthesis" EXACT []
synonym: "estrogen formation" EXACT []
synonym: "estrogen synthesis" EXACT []
synonym: "oestrogen biosynthesis" EXACT []
synonym: "oestrogen biosynthetic process" EXACT []
is_a: GO:0008210 ! estrogen metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0120178 ! steroid hormone biosynthetic process

[Term]
id: GO:0006704
name: glucocorticoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "glucocorticoid anabolism" EXACT []
synonym: "glucocorticoid biosynthesis" EXACT []
synonym: "glucocorticoid formation" EXACT []
synonym: "glucocorticoid synthesis" EXACT []
is_a: GO:0008211 ! glucocorticoid metabolic process
is_a: GO:0120178 ! steroid hormone biosynthetic process

[Term]
id: GO:0006705
name: mineralocorticoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "mineralocorticoid anabolism" EXACT []
synonym: "mineralocorticoid biosynthesis" EXACT []
synonym: "mineralocorticoid formation" EXACT []
synonym: "mineralocorticoid synthesis" EXACT []
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0120178 ! steroid hormone biosynthetic process

[Term]
id: GO:0006706
name: steroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]
synonym: "steroid breakdown" EXACT []
synonym: "steroid catabolism" EXACT []
synonym: "steroid degradation" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0016042 ! lipid catabolic process

[Term]
id: GO:0006707
name: cholesterol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
synonym: "cholesterol breakdown" EXACT []
synonym: "cholesterol catabolism" EXACT []
synonym: "cholesterol degradation" EXACT []
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0016127 ! sterol catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0006708
name: ecdysone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
synonym: "ecdysone breakdown" EXACT []
synonym: "ecdysone catabolism" EXACT []
synonym: "ecdysone degradation" EXACT []
is_a: GO:0008205 ! ecdysone metabolic process
is_a: GO:0016127 ! sterol catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046344 ! ecdysteroid catabolic process

[Term]
id: GO:0006709
name: progesterone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, PMID:11392024]
synonym: "progesterone breakdown" EXACT []
synonym: "progesterone catabolism" EXACT []
synonym: "progesterone degradation" EXACT []
is_a: GO:0008208 ! C21-steroid hormone catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042448 ! progesterone metabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0006710
name: androgen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732]
synonym: "androgen breakdown" EXACT []
synonym: "androgen catabolism" EXACT []
synonym: "androgen degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008209 ! androgen metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006711
name: estrogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]
synonym: "estrogen breakdown" EXACT []
synonym: "estrogen catabolism" EXACT []
synonym: "estrogen degradation" EXACT []
synonym: "oestrogen catabolic process" EXACT []
synonym: "oestrogen catabolism" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008210 ! estrogen metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006712
name: mineralocorticoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "mineralocorticoid breakdown" EXACT []
synonym: "mineralocorticoid catabolism" EXACT []
synonym: "mineralocorticoid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006713
name: glucocorticoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "glucocorticoid breakdown" EXACT []
synonym: "glucocorticoid catabolism" EXACT []
synonym: "glucocorticoid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0006714
name: sesquiterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684]
synonym: "sesquiterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0006715
name: farnesol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684]
synonym: "farnesol anabolism" EXACT []
synonym: "farnesol biosynthesis" EXACT []
synonym: "farnesol formation" EXACT []
synonym: "farnesol synthesis" EXACT []
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0016487 ! farnesol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process

[Term]
id: GO:0006716
name: juvenile hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0006717
name: obsolete juvenile hormone binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "juvenile hormone binding" EXACT []
is_obsolete: true
consider: GO:0005500

[Term]
id: GO:0006718
name: juvenile hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone anabolism" EXACT []
synonym: "juvenile hormone biosynthesis" EXACT []
synonym: "juvenile hormone formation" EXACT []
synonym: "juvenile hormone synthesis" EXACT []
is_a: GO:0006716 ! juvenile hormone metabolic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0006719
name: juvenile hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone breakdown" EXACT []
synonym: "juvenile hormone catabolism" EXACT []
synonym: "juvenile hormone degradation" EXACT []
is_a: GO:0006716 ! juvenile hormone metabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006720
name: isoprenoid metabolic process
namespace: biological_process
alt_id: GO:0016096
def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684]
synonym: "isoprenoid metabolism" EXACT []
synonym: "polyisoprenoid metabolic process" NARROW []
synonym: "polyisoprenoid metabolism" NARROW []
synonym: "polyterpene metabolic process" NARROW []
synonym: "polyterpene metabolism" NARROW []
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0006721
name: terpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732]
synonym: "terpenoid metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0006722
name: triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684]
synonym: "triterpene metabolic process" NARROW []
synonym: "triterpene metabolism" NARROW []
synonym: "triterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0006723
name: cuticle hydrocarbon biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai]
synonym: "cuticle hydrocarbon anabolism" EXACT []
synonym: "cuticle hydrocarbon biosynthesis" EXACT []
synonym: "cuticle hydrocarbon formation" EXACT []
synonym: "cuticle hydrocarbon synthesis" EXACT []
is_a: GO:0120251 ! hydrocarbon biosynthetic process
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0006725
name: obsolete cellular aromatic compound metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0008152

[Term]
id: GO:0006726
name: eye pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment anabolism" EXACT []
synonym: "eye pigment biosynthesis" EXACT []
synonym: "eye pigment formation" EXACT []
synonym: "eye pigment synthesis" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006727
name: ommochrome biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
synonym: "ommochrome anabolism" EXACT []
synonym: "ommochrome biosynthesis" EXACT []
synonym: "ommochrome formation" EXACT []
synonym: "ommochrome synthesis" EXACT []
is_a: GO:0006726 ! eye pigment biosynthetic process
is_a: GO:0008055 ! ocellus pigment biosynthetic process
is_a: GO:0046152 ! ommochrome metabolic process

[Term]
id: GO:0006728
name: pteridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
synonym: "pteridine anabolism" EXACT []
synonym: "pteridine biosynthesis" EXACT []
synonym: "pteridine formation" EXACT []
synonym: "pteridine synthesis" EXACT []
synonym: "pterin biosynthesis" NARROW []
synonym: "pterin biosynthetic process" NARROW []
is_a: GO:0019889 ! pteridine metabolic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006729
name: tetrahydrobiopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]
synonym: "5,6,7,8-tetrahydrobiopterin biosynthetic process" EXACT []
synonym: "tetrahydrobiopterin anabolism" EXACT []
synonym: "tetrahydrobiopterin biosynthesis" EXACT []
synonym: "tetrahydrobiopterin formation" EXACT []
synonym: "tetrahydrobiopterin synthesis" EXACT []
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process

[Term]
id: GO:0006730
name: one-carbon metabolic process
namespace: biological_process
alt_id: GO:0019753
alt_id: GO:0019754
def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
subset: goslim_pir
synonym: "one carbon metabolic process" EXACT [GOC:mah]
synonym: "one carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolism" EXACT [GOC:mah]
xref: UM-BBD_pathwayID:C1cyc
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006731
name: obsolete coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
consider: GO:0051189

[Term]
id: GO:0006732
name: obsolete coenzyme metabolic process
namespace: biological_process
alt_id: GO:0006752
def: "OBSOLETE. The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "coenzyme metabolism" EXACT []
synonym: "group transfer coenzyme metabolic process" NARROW []
synonym: "group transfer coenzyme metabolism" NARROW []
is_obsolete: true

[Term]
id: GO:0006733
name: obsolete oxidoreduction coenzyme metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "oxidoreduction coenzyme metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0006734
name: NADH metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
synonym: "NAD (reduced) metabolic process" EXACT []
synonym: "NAD (reduced) metabolism" EXACT []
synonym: "NADH metabolism" EXACT []
synonym: "reduced NAD metabolic process" EXACT []
synonym: "reduced NAD metabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT []
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0006735
name: NADH regeneration
namespace: biological_process
def: "A metabolic process that generates a pool of NADH by the reduction of NAD+." [GOC:mah]
synonym: "NAD (reduced) regeneration" EXACT []
synonym: "reduced NAD regeneration" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT []
is_a: GO:0006734 ! NADH metabolic process

[Term]
id: GO:0006738
name: nicotinamide riboside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732]
synonym: "N-ribosylnicotinamide catabolic process" EXACT []
synonym: "nicotinamide riboside breakdown" EXACT []
synonym: "nicotinamide riboside catabolism" EXACT []
synonym: "nicotinamide riboside degradation" EXACT []
is_a: GO:0046495 ! nicotinamide riboside metabolic process
is_a: GO:0070638 ! pyridine nucleoside catabolic process

[Term]
id: GO:0006739
name: NADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
synonym: "NAD phosphorylation and dephosphorylation" RELATED []
synonym: "NADP (oxidized) metabolic process" EXACT []
synonym: "NADP (oxidized) metabolism" EXACT []
synonym: "NADP (reduced) metabolic process" EXACT []
synonym: "NADP (reduced) metabolism" EXACT []
synonym: "NADP metabolism" EXACT []
synonym: "NADPH metabolic process" EXACT []
synonym: "NADPH metabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
synonym: "oxidized NADP metabolic process" EXACT []
synonym: "oxidized NADP metabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
synonym: "reduced NADP metabolic process" EXACT []
synonym: "reduced NADP metabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0006740
name: NADPH regeneration
namespace: biological_process
def: "A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah]
synonym: "NADP (reduced) regeneration" EXACT []
synonym: "reduced NADP regeneration" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT []
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0006739 ! NADP metabolic process

[Term]
id: GO:0006741
name: NADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
synonym: "NADP (oxidized) biosynthesis" EXACT []
synonym: "NADP (oxidized) biosynthetic process" EXACT []
synonym: "NADP (reduced) biosynthesis" EXACT []
synonym: "NADP (reduced) biosynthetic process" EXACT []
synonym: "NADP anabolism" EXACT []
synonym: "NADP biosynthesis" EXACT []
synonym: "NADP formation" EXACT []
synonym: "NADP synthesis" EXACT []
synonym: "NADPH biosynthesis" EXACT []
synonym: "NADPH biosynthetic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
synonym: "oxidized NADP biosynthesis" EXACT []
synonym: "oxidized NADP biosynthetic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
synonym: "reduced NADP biosynthesis" EXACT []
synonym: "reduced NADP biosynthetic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0006742
name: NADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
synonym: "NADP (oxidized) catabolic process" EXACT []
synonym: "NADP (oxidized) catabolism" EXACT []
synonym: "NADP (reduced) catabolic process" EXACT []
synonym: "NADP (reduced) catabolism" EXACT []
synonym: "NADP breakdown" EXACT []
synonym: "NADP catabolism" EXACT []
synonym: "NADP degradation" EXACT []
synonym: "NADPH catabolic process" EXACT []
synonym: "NADPH catabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
synonym: "oxidized NADP catabolic process" EXACT []
synonym: "oxidized NADP catabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
synonym: "reduced NADP catabolic process" EXACT []
synonym: "reduced NADP catabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0019364 ! pyridine nucleotide catabolic process

[Term]
id: GO:0006743
name: ubiquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
synonym: "coenzyme Q metabolic process" EXACT []
synonym: "coenzyme Q metabolism" EXACT []
synonym: "ubiquinone metabolism" EXACT []
is_a: GO:1901661 ! quinone metabolic process

[Term]
id: GO:0006744
name: ubiquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
subset: goslim_drosophila
subset: goslim_pombe
synonym: "coenzyme Q biosynthesis" EXACT []
synonym: "coenzyme Q biosynthetic process" EXACT []
synonym: "coenzyme Q10 biosynthesis" NARROW []
synonym: "coenzyme Q10 biosynthetic process" NARROW []
synonym: "coenzyme Q6 biosynthesis" NARROW []
synonym: "coenzyme Q6 biosynthetic process" NARROW []
synonym: "coenzyme Q8 biosynthesis" NARROW []
synonym: "coenzyme Q8 biosynthetic process" NARROW []
synonym: "coenzyme Q9 biosynthesis" NARROW []
synonym: "coenzyme Q9 biosynthetic process" NARROW []
synonym: "ubiquinone anabolism" EXACT []
synonym: "ubiquinone biosynthesis" EXACT []
synonym: "ubiquinone formation" EXACT []
synonym: "ubiquinone synthesis" EXACT []
xref: MetaCyc:UBISYN-PWY
is_a: GO:0006743 ! ubiquinone metabolic process
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0006746
name: FADH2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [GOC:ai]
synonym: "FADH2 metabolism" EXACT []
synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah]
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process

[Term]
id: GO:0006747
name: FAD biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide." [GOC:ai, PMID:20822113]
synonym: "FAD anabolism" EXACT []
synonym: "FAD biosynthesis" EXACT []
synonym: "FAD formation" EXACT []
synonym: "FAD synthesis" EXACT []
synonym: "oxidized flavin adenine dinucleotide biosynthesis" EXACT []
synonym: "oxidized flavin adenine dinucleotide biosynthetic process" EXACT []
synonym: "oxidized flavin-adenine dinucleotide biosynthesis" EXACT []
synonym: "oxidized flavin-adenine dinucleotide biosynthetic process" EXACT []
is_a: GO:0046443 ! FAD metabolic process
is_a: GO:0072388 ! flavin adenine dinucleotide biosynthetic process

[Term]
id: GO:0006748
name: lipoamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators]
synonym: "lipoamide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0006749
name: glutathione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]
synonym: "glutathione metabolism" EXACT []
synonym: "oxidized glutathione reduction" NARROW []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0006750
name: glutathione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]
synonym: "glutathione anabolism" EXACT []
synonym: "glutathione biosynthesis" EXACT []
synonym: "glutathione formation" EXACT []
synonym: "glutathione synthesis" EXACT []
xref: MetaCyc:GLUTATHIONESYN-PWY
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0006751
name: glutathione catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, ISBN:0198506732]
synonym: "glutathione breakdown" EXACT []
synonym: "glutathione catabolism" EXACT []
synonym: "glutathione degradation" EXACT []
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0006753
name: nucleoside phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah]
synonym: "nucleoside phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0006754
name: ATP biosynthetic process
namespace: biological_process
alt_id: GO:0006758
alt_id: GO:0006759
def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]
synonym: "ATP anabolism" EXACT []
synonym: "ATP biosynthesis" EXACT []
synonym: "ATP formation" EXACT []
synonym: "ATP regeneration" NARROW []
synonym: "ATP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046034 ! ATP metabolic process

[Term]
id: GO:0006755
name: obsolete carbamoyl phosphate-ADP transphosphorylation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2).
synonym: "carbamoyl phosphate-ADP transphosphorylation" EXACT []
is_obsolete: true

[Term]
id: GO:0006756
name: AMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai]
is_a: GO:0006754 ! ATP biosynthetic process
is_a: GO:0046033 ! AMP metabolic process
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation

[Term]
id: GO:0006757
name: obsolete ATP generation from ADP
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai]
comment: The reason for obsoletion is that this term represents a single step MF.
synonym: "ADP phosphorylation" EXACT [GOC:dph]
is_obsolete: true

[Term]
id: GO:0006760
name: folic acid-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]
synonym: "folate and derivative metabolic process" EXACT []
synonym: "folate and derivative metabolism" EXACT []
synonym: "folate-containing compound metabolic process" EXACT []
synonym: "folate-containing compound metabolism" EXACT []
synonym: "folic acid and derivative metabolic process" EXACT []
synonym: "folic acid and derivative metabolism" EXACT []
synonym: "folic acid-containing compound metabolism" EXACT []
synonym: "vitamin B9 and derivative metabolic process" EXACT []
synonym: "vitamin B9 and derivative metabolism" EXACT []
synonym: "vitamin M and derivative metabolic process" EXACT []
synonym: "vitamin M and derivative metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0006761
name: dihydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai]
synonym: "7,8-dihydrofolate biosynthesis" EXACT []
synonym: "7,8-dihydrofolate biosynthetic process" EXACT []
synonym: "dihydrofolate anabolism" EXACT []
synonym: "dihydrofolate biosynthesis" EXACT []
synonym: "dihydrofolate formation" EXACT []
synonym: "dihydrofolate synthesis" EXACT []
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046452 ! dihydrofolate metabolic process

[Term]
id: GO:0006762
name: obsolete dihydrofolate reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrofolate reduction" EXACT []
is_obsolete: true
consider: GO:0004146
consider: GO:0046452

[Term]
id: GO:0006766
name: vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai]
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "vitamin metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006767
name: water-soluble vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl]
synonym: "water-soluble vitamin metabolism" EXACT []
is_a: GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0006768
name: biotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732]
synonym: "biotin metabolism" EXACT []
synonym: "vitamin B7 metabolic process" EXACT []
synonym: "vitamin B7 metabolism" EXACT []
synonym: "vitamin H metabolic process" EXACT []
synonym: "vitamin H metabolism" EXACT []
xref: Wikipedia:Biotin
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0006769
name: nicotinamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732]
synonym: "niacin metabolic process" RELATED []
synonym: "niacin metabolism" RELATED []
synonym: "nicotinamide metabolism" EXACT []
synonym: "vitamin B3 metabolic process" BROAD []
synonym: "vitamin B3 metabolism" BROAD []
xref: MetaCyc:PWY-5083
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0006771
name: riboflavin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, PMID:11153262, PMID:24764086]
synonym: "riboflavin metabolism" EXACT []
synonym: "vitamin B2 metabolic process" EXACT []
synonym: "vitamin B2 metabolism" EXACT []
synonym: "vitamin G metabolic process" EXACT []
synonym: "vitamin G metabolism" EXACT []
xref: Wikipedia:Riboflavin
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process

[Term]
id: GO:0006772
name: thiamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732]
synonym: "thiamin metabolic process" EXACT []
synonym: "thiamin metabolism" EXACT []
synonym: "thiamine metabolism" EXACT []
synonym: "vitamin B1 metabolic process" EXACT []
synonym: "vitamin B1 metabolism" EXACT []
xref: Wikipedia:Thiamine
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042723 ! thiamine-containing compound metabolic process

[Term]
id: GO:0006774
name: obsolete vitamin B12 reduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "vitamin B12 reduction" EXACT []
is_obsolete: true
consider: GO:0009235

[Term]
id: GO:0006775
name: fat-soluble vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]
synonym: "fat-soluble vitamin metabolism" EXACT []
is_a: GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0006776
name: vitamin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, PMID:1503811]
synonym: "vitamin A metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0006775 ! fat-soluble vitamin metabolic process

[Term]
id: GO:0006777
name: Mo-molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [ISSN:09498257, PMID:22370186, PMID:23201473]
synonym: "Mo-molybdopterin cofactor anabolism" EXACT []
synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT []
synonym: "Mo-molybdopterin cofactor formation" EXACT []
synonym: "Mo-molybdopterin cofactor synthesis" EXACT []
synonym: "Moco biosynthesis" EXACT []
synonym: "Moco biosynthetic process" EXACT []
synonym: "molybdenum cofactor biosynthetic process" RELATED []
xref: MetaCyc:PWY-6823
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process

[Term]
id: GO:0006778
name: porphyrin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]
synonym: "porphyrin metabolic process" RELATED []
synonym: "porphyrin metabolism" RELATED []
is_a: GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:0006779
name: porphyrin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]
synonym: "porphyrin anabolism" RELATED []
synonym: "porphyrin biosynthesis" RELATED []
synonym: "porphyrin biosynthetic process" RELATED []
synonym: "porphyrin formation" RELATED []
synonym: "porphyrin synthesis" RELATED []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:0006780
name: uroporphyrinogen III biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai]
synonym: "uroporphyrinogen III anabolism" EXACT []
synonym: "uroporphyrinogen III biosynthesis" EXACT []
synonym: "uroporphyrinogen III formation" EXACT []
synonym: "uroporphyrinogen III synthesis" EXACT []
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046502 ! uroporphyrinogen III metabolic process

[Term]
id: GO:0006781
name: succinyl-CoA pathway
namespace: biological_process
def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479]
synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT []
synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT []
synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT []
synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT []
synonym: "succinyl CoA pathway" EXACT []
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process

[Term]
id: GO:0006782
name: protoporphyrinogen IX biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators]
synonym: "protoporphyrinogen IX anabolism" EXACT []
synonym: "protoporphyrinogen IX biosynthesis" EXACT []
synonym: "protoporphyrinogen IX formation" EXACT []
synonym: "protoporphyrinogen IX synthesis" EXACT []
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0046501 ! protoporphyrinogen IX metabolic process
relationship: part_of GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0006783
name: heme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]
synonym: "haem biosynthesis" EXACT []
synonym: "haem biosynthetic process" EXACT []
synonym: "heme anabolism" EXACT []
synonym: "heme biosynthesis" EXACT []
synonym: "heme formation" EXACT []
synonym: "heme synthesis" EXACT []
xref: MetaCyc:HEMESYN2-PWY
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0042168 ! heme metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006784
name: heme A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3." [GOC:ai, PMID:11788607]
synonym: "haem A biosynthesis" EXACT []
synonym: "haem A biosynthetic process" EXACT []
synonym: "heme A anabolism" EXACT []
synonym: "heme A biosynthesis" EXACT []
synonym: "heme A formation" EXACT []
synonym: "heme A synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046160 ! heme a metabolic process

[Term]
id: GO:0006785
name: heme B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme B, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, PMID:29414780]
synonym: "haem B biosynthesis" EXACT []
synonym: "haem B biosynthetic process" EXACT []
synonym: "heme B anabolism" EXACT []
synonym: "heme B biosynthesis" EXACT []
synonym: "heme B formation" EXACT []
synonym: "heme B synthesis" EXACT []
synonym: "protoheme biosynthesis" EXACT []
synonym: "protoheme biosynthetic process" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046492 ! heme B metabolic process

[Term]
id: GO:0006786
name: heme C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208]
synonym: "haem C biosynthesis" EXACT []
synonym: "haem C biosynthetic process" EXACT []
synonym: "heme C anabolism" EXACT []
synonym: "heme C biosynthesis" EXACT []
synonym: "heme C formation" EXACT []
synonym: "heme C synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046162 ! heme C metabolic process

[Term]
id: GO:0006787
name: porphyrin-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
synonym: "porphyrin breakdown" RELATED []
synonym: "porphyrin catabolic process" RELATED []
synonym: "porphyrin catabolism" RELATED []
synonym: "porphyrin degradation" RELATED []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process

[Term]
id: GO:0006788
name: heme oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah]
synonym: "haem oxidation" EXACT []
is_a: GO:0042168 ! heme metabolic process
relationship: part_of GO:0006787 ! porphyrin-containing compound catabolic process

[Term]
id: GO:0006789
name: bilirubin conjugation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin." [DOI:10.1016/0305-0491(80)90243-6]
is_a: GO:0006787 ! porphyrin-containing compound catabolic process

[Term]
id: GO:0006790
name: sulfur compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "sulfur metabolism" EXACT []
synonym: "sulphur metabolic process" EXACT []
synonym: "sulphur metabolism" EXACT []
xref: Wikipedia:Sulfur_metabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006791
name: sulfur utilization
namespace: biological_process
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
synonym: "sulphur utilization" EXACT []
is_a: GO:0031667 ! response to nutrient levels

[Term]
id: GO:0006792
name: regulation of sulfur utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
synonym: "regulation of sulphur utilization" EXACT []
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0006793
name: phosphorus metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]
subset: goslim_pir
synonym: "phosphorus metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006794
name: phosphorus utilization
namespace: biological_process
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0006795
name: regulation of phosphorus utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0006796
name: phosphate-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]
synonym: "phosphate metabolic process" RELATED []
synonym: "phosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0006797
name: polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732]
synonym: "polyphosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0006798
name: polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732]
synonym: "polyphosphate breakdown" EXACT []
synonym: "polyphosphate catabolism" EXACT []
synonym: "polyphosphate degradation" EXACT []
is_a: GO:0006797 ! polyphosphate metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0006799
name: polyphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732]
synonym: "polyphosphate anabolism" EXACT []
synonym: "polyphosphate biosynthesis" EXACT []
synonym: "polyphosphate formation" EXACT []
synonym: "polyphosphate synthesis" EXACT []
is_a: GO:0006797 ! polyphosphate metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0006800
name: obsolete oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "oxygen and active oxygen species metabolism" EXACT []
synonym: "oxygen and AOS metabolism" EXACT []
synonym: "oxygen and reactive oxidative species metabolism" EXACT []
synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT []
synonym: "oxygen and reactive oxygen species metabolic process" EXACT []
synonym: "oxygen and reactive oxygen species metabolism" EXACT []
synonym: "oxygen and ROI metabolism" EXACT []
synonym: "oxygen and ROS metabolic process" EXACT []
synonym: "oxygen and ROS metabolism" EXACT []
is_obsolete: true
consider: GO:0072592
consider: GO:0072593

[Term]
id: GO:0006801
name: superoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl]
synonym: "oxygen free radical metabolic process" EXACT []
synonym: "oxygen free radical metabolism" EXACT []
synonym: "superoxide free radical metabolic process" EXACT []
synonym: "superoxide free radical metabolism" EXACT []
synonym: "superoxide metabolism" EXACT []
is_a: GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:0006802
name: obsolete catalase reaction
namespace: biological_process
def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904]
comment: This term was made obsolete because it represents a molecular function.
synonym: "catalase reaction" EXACT []
synonym: "hydroperoxidase reaction" RELATED []
is_obsolete: true
consider: GO:0004096

[Term]
id: GO:0006803
name: obsolete glutathione conjugation reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "glutathione conjugation reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004364

[Term]
id: GO:0006804
name: obsolete peroxidase reaction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "peroxidase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004601

[Term]
id: GO:0006805
name: xenobiotic metabolic process
namespace: biological_process
alt_id: GO:0017144
def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc]
subset: goslim_chembl
subset: goslim_pir
synonym: "drug metabolic process" RELATED []
synonym: "drug metabolism" RELATED []
synonym: "xenobiotic metabolism" EXACT []
xref: Wikipedia:Drug_metabolism
xref: Wikipedia:Xenobiotic_metabolism
is_a: GO:0008152 ! metabolic process
relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus

[Term]
id: GO:0006806
name: obsolete insecticide resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "insecticide resistance" EXACT []
is_obsolete: true
replaced_by: GO:0017085

[Term]
id: GO:0006807
name: obsolete nitrogen compound metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0008152

[Term]
id: GO:0006808
name: regulation of nitrogen utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
subset: goslim_metagenomics
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0006809
name: nitric oxide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
synonym: "nitric oxide anabolism" EXACT []
synonym: "nitric oxide biosynthesis" EXACT []
synonym: "nitric oxide formation" EXACT []
synonym: "nitric oxide synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
alt_id: GO:0044765
def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "single-organism transport" RELATED []
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0006811
name: monoatomic ion transport
namespace: biological_process
def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "ion transport" BROAD []
is_a: GO:0006810 ! transport

[Term]
id: GO:0006812
name: monoatomic cation transport
namespace: biological_process
alt_id: GO:0006819
alt_id: GO:0015674
alt_id: GO:0072512
def: "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]
synonym: "cation transport" BROAD []
synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah]
synonym: "trivalent inorganic cation transport" NARROW []
is_a: GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0006813
name: potassium ion transport
namespace: biological_process
alt_id: GO:0015458
alt_id: GO:0071804
def: "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "cellular potassium ion transport" EXACT []
synonym: "K+ conductance" RELATED []
synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "potassium conductance" NARROW []
synonym: "potassium ion conductance" NARROW []
synonym: "potassium transport" RELATED []
synonym: "sodium/potassium transport" BROAD []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0006814
name: sodium ion transport
namespace: biological_process
alt_id: GO:0006834
alt_id: GO:0016974
def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "sodium transport" EXACT []
synonym: "sodium/potassium transport" BROAD []
synonym: "sodium:calcium exchange" NARROW []
synonym: "sodium:solute transport" NARROW []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0006815
name: obsolete sodium/potassium transport
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "sodium/potassium transport" EXACT []
is_obsolete: true
consider: GO:0006813
consider: GO:0006814

[Term]
id: GO:0006816
name: calcium ion transport
namespace: biological_process
def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "calcium transport" EXACT []
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
synonym: "sodium:calcium exchange" NARROW []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0006817
name: phosphate ion transport
namespace: biological_process
def: "The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "phosphate transport" RELATED []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0006820
name: monoatomic anion transport
namespace: biological_process
alt_id: GO:0006822
def: "The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:ai]
synonym: "anion transport" BROAD []
is_a: GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0006821
name: chloride transport
namespace: biological_process
def: "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006820 ! monoatomic anion transport
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0006823
name: obsolete heavy metal ion transport
namespace: biological_process
def: "OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal ion transport" EXACT []
is_obsolete: true
consider: GO:0030001

[Term]
id: GO:0006824
name: cobalt ion transport
namespace: biological_process
def: "The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "cobalt transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0006825
name: copper ion transport
namespace: biological_process
def: "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006826
name: iron ion transport
namespace: biological_process
alt_id: GO:0015681
alt_id: GO:0015682
alt_id: GO:0015684
alt_id: GO:0033216
alt_id: GO:0097286
def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "ferric ion import" NARROW []
synonym: "ferric ion transport" NARROW []
synonym: "ferric iron import" NARROW []
synonym: "ferric iron transport" NARROW []
synonym: "ferric iron uptake" NARROW []
synonym: "ferrous ion transport" NARROW []
synonym: "ferrous iron transport" NARROW []
synonym: "iron ion import" RELATED []
synonym: "iron transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006828
name: manganese ion transport
namespace: biological_process
def: "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006829
name: zinc ion transport
namespace: biological_process
def: "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "zinc II ion transport" EXACT []
synonym: "zinc transport" EXACT [GOC:mah]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006832
name: obsolete small molecule transport
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "small molecule transport" EXACT []
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0006833
name: water transport
namespace: biological_process
def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0042044 ! fluid transport

[Term]
id: GO:0006835
name: dicarboxylic acid transport
namespace: biological_process
alt_id: GO:0006841
def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "sodium:dicarboxylate transport" RELATED []
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006836
name: neurotransmitter transport
namespace: biological_process
def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
subset: goslim_pir
synonym: "sodium:neurotransmitter transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0006837
name: serotonin transport
namespace: biological_process
def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0006838
name: obsolete allantoin/allantoate transport
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "allantoin/allantoate transport" EXACT []
is_obsolete: true
consider: GO:0015719
consider: GO:0015720

[Term]
id: GO:0006839
name: mitochondrial transport
namespace: biological_process
def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai]
subset: goslim_drosophila
is_a: GO:0006810 ! transport

[Term]
id: GO:0006840
name: obsolete mitochondrial alpha-ketoglutarate/malate transport
namespace: biological_process
def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "mitochondrial alpha-ketoglutarate/malate transport" EXACT []
synonym: "mitochondrial oxoglutarate/malate transport" EXACT []
is_obsolete: true
consider: GO:0006839
consider: GO:0015367
consider: GO:0015742
consider: GO:0015743

[Term]
id: GO:0006842
name: tricarboxylic acid transport
namespace: biological_process
def: "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006843
name: mitochondrial citrate transmembrane transport
namespace: biological_process
alt_id: GO:1990541
def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix." [GOC:ai, PMID:20371607]
synonym: "mitochondrial citrate transport" RELATED []
is_a: GO:0015746 ! citrate transport
is_a: GO:1990546 ! mitochondrial tricarboxylic acid transmembrane transport

[Term]
id: GO:0006844
name: acyl carnitine transport
namespace: biological_process
def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai]
is_a: GO:0015697 ! quaternary ammonium group transport

[Term]
id: GO:0006845
name: obsolete mitochondrial aspartate/glutamate transport
namespace: biological_process
def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "mitochondrial aspartate/glutamate transport" EXACT []
is_obsolete: true
consider: GO:0006839
consider: GO:0015810
consider: GO:0015813

[Term]
id: GO:0006846
name: acetate transport
namespace: biological_process
def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0006847
name: plasma membrane acetate transport
namespace: biological_process
def: "The directed movement of acetate across a plasma membrane." [GOC:ai]
is_a: GO:0035433 ! acetate transmembrane transport

[Term]
id: GO:0006848
name: pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0006849
name: plasma membrane pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai]
is_a: GO:1901475 ! pyruvate transmembrane transport

[Term]
id: GO:0006850
name: mitochondrial pyruvate transmembrane transport
namespace: biological_process
alt_id: GO:1902361
def: "The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558]
synonym: "mitochondrial pyruvate transport" RELATED []
synonym: "pyruvate membrane transport in mitochondria" RELATED []
synonym: "pyruvate membrane transport in mitochondrion" RELATED []
synonym: "pyruvate transmembrane transport in mitochondria" RELATED []
synonym: "pyruvate transmembrane transport in mitochondrion" RELATED []
is_a: GO:1901475 ! pyruvate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0006851
name: mitochondrial calcium ion transmembrane transport
namespace: biological_process
def: "The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai]
synonym: "mitochondrial calcium transport" EXACT []
is_a: GO:0070588 ! calcium ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0006852
name: obsolete mitochondrial sodium/calcium ion exchange
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents function rather than a process.
synonym: "mitochondrial sodium/calcium exchange" EXACT []
synonym: "mitochondrial sodium/calcium ion exchange" EXACT []
is_obsolete: true
consider: GO:0005432
consider: GO:0006814
consider: GO:0006816
consider: GO:0006839

[Term]
id: GO:0006853
name: carnitine shuttle
namespace: biological_process
def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0032365 ! intracellular lipid transport
is_a: GO:1902001 ! fatty acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0006854
name: obsolete ATP/ADP exchange
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "ATP/ADP exchange" EXACT []
is_obsolete: true
replaced_by: GO:0005471

[Term]
id: GO:0006855
name: xenobiotic transmembrane transport
namespace: biological_process
def: "The process in which a xenobiotic, a compound foreign to the organism exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:ai, GOC:bf, GOC:krc]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "drug membrane transport" EXACT []
synonym: "drug transmembrane transport" RELATED []
synonym: "multidrug transport" RELATED []
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0006856
name: eye pigment precursor transport
namespace: biological_process
def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006810 ! transport
relationship: part_of GO:0048066 ! developmental pigmentation

[Term]
id: GO:0006857
name: oligopeptide transport
namespace: biological_process
def: "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732]
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0006858
name: extracellular transport
namespace: biological_process
def: "The transport of substances that occurs outside cells." [GOC:go_curators]
is_a: GO:0006810 ! transport

[Term]
id: GO:0006859
name: obsolete extracellular carbohydrate transport
namespace: biological_process
def: "OBSOLETE. The directed extracellular movement of carbohydrates." [GOC:ai]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0006860
name: extracellular amino acid transport
namespace: biological_process
def: "The directed extracellular movement of amino acids." [GOC:ai]
is_a: GO:0006858 ! extracellular transport
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0006862
name: nucleotide transport
namespace: biological_process
def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732]
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0006863
name: purine nucleobase transport
namespace: biological_process
alt_id: GO:0015852
def: "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
synonym: "purine base transmembrane transport" EXACT [GOC:mah]
synonym: "purine base transport" EXACT [GOC:go_curators]
synonym: "purine transmembrane transport" RELATED [GOC:mah]
synonym: "purine transport" RELATED []
is_a: GO:0015851 ! nucleobase transport

[Term]
id: GO:0006864
name: pyrimidine nucleotide transport
namespace: biological_process
def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0006865
name: amino acid transport
namespace: biological_process
alt_id: GO:0006866
def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006810 ! transport

[Term]
id: GO:0006867
name: asparagine transport
namespace: biological_process
def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-asparagine transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0006868
name: glutamine transport
namespace: biological_process
alt_id: GO:0015815
def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-glutamine transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0006869
name: lipid transport
namespace: biological_process
def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006810 ! transport
relationship: part_of GO:0010876 ! lipid localization

[Term]
id: GO:0006873
name: intracellular monoatomic ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]
subset: goslim_yeast
synonym: "cellular ion homeostasis" BROAD []
synonym: "cellular monoatomic ion homeostasis" EXACT []
is_a: GO:0050801 ! monoatomic ion homeostasis
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0006874
name: intracellular calcium ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]
synonym: "cellular calcium ion homeostasis" EXACT []
synonym: "regulation of calcium ion concentration" BROAD []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0055074 ! calcium ion homeostasis

[Term]
id: GO:0006875
name: obsolete intracellular metal ion homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of metal ions within a cell." [GOC:ai, GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "cellular heavy metal ion homeostasis" NARROW []
synonym: "cellular metal ion homeostasis" EXACT []
is_obsolete: true
replaced_by: GO:0030003

[Term]
id: GO:0006876
name: obsolete intracellular cadmium ion homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of cadmium ions within a cell." [GOC:ai, GOC:mah]
comment: This term was obsoleted because it is not a normal process.
synonym: "cadmium homeostasis" BROAD []
synonym: "cellular cadmium ion homeostasis" EXACT []
is_obsolete: true
consider: GO:0098849

[Term]
id: GO:0006877
name: intracellular cobalt ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of cobalt (Co2+) ions within a cell." [GOC:ai, GOC:mah]
synonym: "cellular cobalt ion homeostasis" EXACT []
synonym: "cobalt homeostasis" BROAD []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0006878
name: intracellular copper ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell." [GOC:ai, GOC:mah]
synonym: "cellular copper ion homeostasis" EXACT []
synonym: "copper homeostasis" BROAD []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0055070 ! copper ion homeostasis

[Term]
id: GO:0006879
name: intracellular iron ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]
synonym: "cellular iron ion homeostasis" EXACT []
synonym: "iron homeostasis" BROAD []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0006880
name: obsolete intracellular sequestering of iron ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "intracellular iron ion retention" EXACT []
synonym: "intracellular iron ion sequestering" EXACT []
synonym: "intracellular iron ion sequestration" EXACT []
synonym: "intracellular iron ion storage" EXACT []
synonym: "intracellular retention of iron ion" EXACT []
synonym: "intracellular sequestration of iron ion" EXACT []
synonym: "intracellular storage of iron ion" EXACT []
is_obsolete: true
consider: GO:0140315

[Term]
id: GO:0006881
name: obsolete extracellular sequestering of iron ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai, GOC:cjm]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "extracellular iron ion retention" EXACT []
synonym: "extracellular iron ion sequestering" EXACT []
synonym: "extracellular iron ion sequestration" EXACT []
synonym: "extracellular iron ion storage" EXACT []
synonym: "extracellular retention of iron ion" EXACT []
synonym: "extracellular sequestration of iron ion" EXACT []
synonym: "extracellular storage of iron ion" EXACT []
is_obsolete: true
consider: GO:0140315

[Term]
id: GO:0006882
name: intracellular zinc ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]
synonym: "cellular zinc ion homeostasis" EXACT []
synonym: "zinc homeostasis" BROAD []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0006883
name: intracellular sodium ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell." [GOC:ai, GOC:mah]
synonym: "cellular sodium ion homeostasis" EXACT []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0055078 ! sodium ion homeostasis

[Term]
id: GO:0006884
name: cell volume homeostasis
namespace: biological_process
def: "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0008361 ! regulation of cell size
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0006885
name: regulation of pH
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0006886
name: intracellular protein transport
namespace: biological_process
alt_id: GO:0032779
def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "copper-induced intracellular protein transport" RELATED [GOC:al]
is_a: GO:0015031 ! protein transport
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0008104 ! protein localization

[Term]
id: GO:0006887
name: exocytosis
namespace: biological_process
alt_id: GO:0016194
alt_id: GO:0016195
def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]
subset: goslim_yeast
synonym: "nonselective vesicle exocytosis" RELATED []
synonym: "vesicle exocytosis" EXACT []
xref: Wikipedia:Exocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0006888
name: endoplasmic reticulum to Golgi vesicle-mediated transport
namespace: biological_process
alt_id: GO:0048221
def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
synonym: "anterograde (ER to Golgi) transport" EXACT []
synonym: "anterograde transport, endoplasmic reticulum to Golgi" EXACT []
synonym: "anterograde transport, ER to Golgi" EXACT []
synonym: "anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi" EXACT []
synonym: "anterograde vesicle-mediated transport, ER to Golgi" EXACT []
synonym: "endoplasmic reticulum to Golgi transport" EXACT []
synonym: "ER to Golgi transport" EXACT []
synonym: "ER to Golgi vesicle-mediated transport" EXACT []
synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT []
synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT []
synonym: "rough ER to cis-Golgi transport" EXACT []
synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT []
is_a: GO:0046907 ! intracellular transport
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006889
name: obsolete regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
synonym: "regulation of calcium in ER" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0006890
name: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
namespace: biological_process
alt_id: GO:0048220
def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT []
synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT []
synonym: "cis-Golgi to rough ER transport" EXACT []
synonym: "cis-Golgi to rough ER vesicle-mediated transport" EXACT []
synonym: "retrograde (Golgi to ER) transport" EXACT []
synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT []
synonym: "retrograde transport, Golgi to ER" EXACT []
synonym: "retrograde vesicle-mediated transport, Golgi to ER" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006891
name: intra-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]
synonym: "intra-Golgi transport" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006892
name: post-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]
synonym: "post-Golgi transport" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006893
name: Golgi to plasma membrane transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]
synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane

[Term]
id: GO:0006894
name: obsolete Golgi to secretory vesicle transport
namespace: biological_process
def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363]
comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms.
synonym: "Golgi to secretory vesicle transport" EXACT []
synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT []
is_obsolete: true
consider: GO:0055107
consider: GO:0055108

[Term]
id: GO:0006895
name: Golgi to endosome transport
namespace: biological_process
alt_id: GO:0048218
def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832]
synonym: "Golgi to endosome vesicle-mediated transport" EXACT []
synonym: "TGN to endosome transport" EXACT []
synonym: "trans-Golgi to endosome transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport

[Term]
id: GO:0006896
name: Golgi to vacuole transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai]
synonym: "Golgi to vacuole vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0006897
name: endocytosis
namespace: biological_process
alt_id: GO:0016193
alt_id: GO:0016196
alt_id: GO:0098701
def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]
subset: goslim_yeast
synonym: "endocytic import into cell" EXACT []
synonym: "nonselective vesicle endocytosis" RELATED []
synonym: "plasma membrane invagination" NARROW []
synonym: "vesicle endocytosis" EXACT []
xref: Wikipedia:Endocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0098657 ! import into cell

[Term]
id: GO:0006898
name: receptor-mediated endocytosis
namespace: biological_process
def: "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
synonym: "receptor mediated endocytosis" EXACT []
xref: Wikipedia:Receptor-mediated_endocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006900
name: vesicle budding from membrane
namespace: biological_process
alt_id: GO:0006902
alt_id: GO:1902591
def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]
synonym: "membrane evagination" EXACT []
synonym: "nonselective vesicle assembly" RELATED []
synonym: "single organism membrane budding" RELATED [GOC:TermGenie]
synonym: "single-organism membrane budding" RELATED []
synonym: "vesicle biosynthesis" EXACT []
synonym: "vesicle budding" RELATED []
synonym: "vesicle formation" EXACT []
is_a: GO:0016050 ! vesicle organization
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006901
name: vesicle coating
namespace: biological_process
def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid]
synonym: "vesicle coat assembly" BROAD []
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0006900 ! vesicle budding from membrane

[Term]
id: GO:0006903
name: vesicle targeting
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0016192 ! vesicle-mediated transport
relationship: part_of GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:0006904
name: vesicle docking involved in exocytosis
namespace: biological_process
def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]
synonym: "vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048278 ! vesicle docking
is_a: GO:0140029 ! exocytic process

[Term]
id: GO:0006905
name: obsolete vesicle transport
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "vesicle transport" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0006906
name: vesicle fusion
namespace: biological_process
def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0090174 ! organelle membrane fusion
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006907
name: pinocytosis
namespace: biological_process
alt_id: GO:0006908
alt_id: GO:1902536
def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane." [ISBN:0198506732]
synonym: "clathrin-independent pinocytosis" BROAD []
synonym: "fluid-phase endocytosis" EXACT []
synonym: "single-organism pinocytosis" RELATED []
xref: Wikipedia:Pinocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006909
name: phagocytosis
namespace: biological_process
def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
xref: Wikipedia:Phagocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006910
name: phagocytosis, recognition
namespace: biological_process
def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149]
comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'.
synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT []
is_a: GO:0008037 ! cell recognition
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0006911
name: phagocytosis, engulfment
namespace: biological_process
def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149]
synonym: "phagosome biosynthesis" RELATED []
synonym: "phagosome formation" RELATED []
is_a: GO:0099024 ! plasma membrane invagination
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0006912
name: obsolete phagosome formation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because of the ambiguity in its meaning.
synonym: "phagosome formation" EXACT []
is_obsolete: true
consider: GO:0001845
consider: GO:0006911

[Term]
id: GO:0006913
name: nucleocytoplasmic transport
namespace: biological_process
alt_id: GO:0000063
def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
synonym: "nucleocytoplasmic shuttling" NARROW []
is_a: GO:0051169 ! nuclear transport

[Term]
id: GO:0006914
name: autophagy
namespace: biological_process
alt_id: GO:0016238
def: "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
xref: Wikipedia:Autophagy_(cellular)
is_a: GO:0009056 ! catabolic process
is_a: GO:0061919 ! process utilizing autophagic mechanism

[Term]
id: GO:0006915
name: apoptotic process
namespace: biological_process
alt_id: GO:0006917
alt_id: GO:0008632
def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
synonym: "activation of apoptosis" NARROW []
synonym: "apoptosis" NARROW []
synonym: "apoptosis activator activity" RELATED []
synonym: "apoptosis signaling" NARROW []
synonym: "apoptotic cell death" EXACT [GOC:sl]
synonym: "apoptotic program" NARROW [GOC:add]
synonym: "apoptotic programmed cell death" EXACT []
synonym: "caspase-dependent programmed cell death" RELATED []
synonym: "cell suicide" BROAD []
synonym: "cellular suicide" BROAD []
synonym: "commitment to apoptosis" RELATED []
synonym: "induction of apoptosis" RELATED []
synonym: "induction of apoptosis by p53" RELATED []
synonym: "programmed cell death by apoptosis" EXACT []
synonym: "signaling (initiator) caspase activity" RELATED []
synonym: "type I programmed cell death" NARROW []
xref: Wikipedia:Apoptosis
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0006918
name: obsolete induction of apoptosis by p53
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more accurate terms were created.
synonym: "induction of apoptosis by p53" EXACT []
is_obsolete: true
consider: GO:0006915

[Term]
id: GO:0006919
name: obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
comment: This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.\nThe reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activation of caspase activity" NARROW []
synonym: "activation of metacaspase activity" NARROW []
synonym: "caspase activation" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:2001056

[Term]
id: GO:0006920
name: obsolete commitment to apoptosis
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more accurate terms were created.
synonym: "commitment to apoptosis" EXACT []
is_obsolete: true
consider: GO:0006915

[Term]
id: GO:0006921
name: cellular component disassembly involved in execution phase of apoptosis
namespace: biological_process
def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb]
synonym: "cellular component disassembly involved in apoptosis" NARROW []
synonym: "cellular component disassembly involved in apoptotic process" BROAD []
synonym: "disassembly of cell structures" BROAD []
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0097194 ! execution phase of apoptosis

[Term]
id: GO:0006922
name: obsolete cleavage of lamin involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, GOC:mtg_apoptosis, ISBN:0815332181]
comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.
synonym: "cleavage of lamin" BROAD []
synonym: "cleavage of lamin involved in execution phase of apoptosis" EXACT []
is_obsolete: true
consider: GO:0004197

[Term]
id: GO:0006923
name: obsolete cleavage of cytoskeletal proteins involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181]
comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.
synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT []
synonym: "cleavage of cytoskeletal proteins involved in apoptosis" BROAD []
synonym: "cleavage of cytoskeletal proteins involved in execution phase of apoptosis" EXACT []
is_obsolete: true
consider: GO:0004197

[Term]
id: GO:0006924
name: activation-induced cell death of T cells
namespace: biological_process
def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196, PMID:12414721, PMID:12752672]
synonym: "activated T cell apoptosis" BROAD [GOC:add]
synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "AICD" BROAD [GOC:add]
synonym: "antigen-driven apoptosis" BROAD [GOC:add]
is_a: GO:0070231 ! T cell apoptotic process
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0006925
name: inflammatory cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis]
synonym: "apoptosis of inflammatory cells" EXACT []
synonym: "inflammatory cell apoptosis" NARROW []
synonym: "inflammatory cell programmed cell death by apoptosis" EXACT []
synonym: "killing of inflammatory cells" EXACT []
synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT []
synonym: "programmed cell death, inflammatory cells" EXACT []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0006926
name: obsolete virus-infected cell apoptotic process
namespace: biological_process
def: "OBSOLETE. Any apoptotic process in a cell infected with a virus." [GOC:jl, GOC:mtg_apoptosis]
comment: This term was made obsolete because the meaning of the term is ambiguous, as it's possibly conflating at least two scenarios: 1) the organism apoptoses its own cell because it detects it is infected with a virus; 2) the virus induces apoptosis so the cell is lysed and the virus disseminated. Please consider using viral process terms to annotate viral proteins. As for the cellular apoptotic process, this likely occurs via the same mechanisms described by existing apoptotic process terms, so please consider using those to annotate cellular proteins.
synonym: "apoptosis of virus-infected cells" EXACT []
synonym: "killing virus-infected cells" EXACT []
synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT []
synonym: "programmed cell death, virus-infected cells" EXACT []
synonym: "virus-infected cell apoptosis" NARROW []
synonym: "virus-infected cell apoptotic process" EXACT []
synonym: "virus-infected cell programmed cell death by apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0006927
name: obsolete transformed cell apoptotic process
namespace: biological_process
def: "OBSOLETE. Any apoptotic process in a transformed cell, a cell that has undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, GOC:mtg_apoptosis]
comment: This term was made obsolete because it does not refer to a normal process.
synonym: "apoptosis of transformed cells" EXACT []
synonym: "killing transformed cells" EXACT []
synonym: "programmed cell death of transformed cells by apoptosis" EXACT []
synonym: "programmed cell death, transformed cells" EXACT []
synonym: "transformed cell apoptosis" NARROW []
synonym: "transformed cell programmed cell death by apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0006928
name: obsolete movement of cell or subcellular component
namespace: biological_process
def: "OBSOLETE. The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg]
comment: This term was obsoleted because it mixes cellular and subcellular processes.
synonym: "cell movement" RELATED []
synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl]
synonym: "cellular component movement" EXACT []
is_obsolete: true

[Term]
id: GO:0006929
name: substrate-dependent cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0006930
name: substrate-dependent cell migration, cell extension
namespace: biological_process
def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell extension" EXACT []
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006931
name: substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell attachment to substrate" EXACT []
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006932
name: substrate-dependent cell migration, cell contraction
namespace: biological_process
def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell contraction" EXACT []
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility
relationship: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006933
name: negative regulation of cell adhesion involved in substrate-bound cell migration
namespace: biological_process
def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007162 ! negative regulation of cell adhesion
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006934
name: substrate-bound cell migration, adhesion receptor recycling
namespace: biological_process
def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043]
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration

[Term]
id: GO:0006935
name: chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
synonym: "taxis in response to chemical stimulus" EXACT []
xref: Wikipedia:Chemotaxis
is_a: GO:0042330 ! taxis
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0006936
name: muscle contraction
namespace: biological_process
def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
subset: goslim_pir
xref: Wikipedia:Muscle_contraction
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0006937
name: regulation of muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]
is_a: GO:0090257 ! regulation of muscle system process
relationship: regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0006939
name: smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "visceral muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction

[Term]
id: GO:0006940
name: regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
relationship: regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0006941
name: striated muscle contraction
namespace: biological_process
def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "sarcomeric muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction

[Term]
id: GO:0006942
name: regulation of striated muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
relationship: regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0006943
name: obsolete chemi-mechanical coupling
namespace: biological_process
def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jid, http://www.m-w.com]
comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO.
synonym: "chemi-mechanical coupling" EXACT []
synonym: "mechanochemical coupling" EXACT []
is_obsolete: true
consider: GO:0009612
consider: GO:0050954

[Term]
id: GO:0006945
name: obsolete nuclear fusion during karyogamy
namespace: biological_process
def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101]
comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology.
synonym: "nuclear fusion during karyogamy" EXACT []
is_obsolete: true
consider: GO:0000741

[Term]
id: GO:0006948
name: obsolete induction by virus of host cell-cell fusion
namespace: biological_process
def: "OBSOLETE. The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325]
comment: This term was obsoleted because it represents the same process as positive regulation of syncytium formation by virus ; GO:0060141.
synonym: "induction by virus of cell-cell fusion in host" EXACT []
synonym: "viral-induced cell-cell fusion" EXACT []
synonym: "viral-induced host cell-cell fusion" EXACT []
synonym: "viral-induced membrane fusion" NARROW []
is_obsolete: true
replaced_by: GO:0060141

[Term]
id: GO:0006949
name: syncytium formation
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0006950
name: response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "response to abiotic stress" RELATED []
synonym: "response to biotic stress" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006952
name: defense response
namespace: biological_process
alt_id: GO:0002217
alt_id: GO:0042829
def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
synonym: "antimicrobial peptide activity" RELATED []
synonym: "defence response" EXACT []
synonym: "defense/immunity protein activity" RELATED []
synonym: "physiological defense response" EXACT []
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006953
name: acute-phase response
namespace: biological_process
def: "An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0006954
name: inflammatory response
namespace: biological_process
def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732]
subset: goslim_generic
synonym: "inflammation" BROAD []
xref: Wikipedia:Inflammation
is_a: GO:0006952 ! defense response

[Term]
id: GO:0006955
name: immune response
namespace: biological_process
def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]
subset: goslim_drosophila
is_a: GO:0002376 ! immune system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006956
name: complement activation
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "complement activity" RELATED []
synonym: "complement cascade" EXACT [GOC:add]
synonym: "complement response" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0002253 ! activation of immune response
is_a: GO:0006959 ! humoral immune response

[Term]
id: GO:0006957
name: complement activation, alternative pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149]
synonym: "complement cascade, alternative pathway" EXACT [GOC:add]
is_a: GO:0006956 ! complement activation
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0006958
name: complement activation, classical pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149]
synonym: "complement cascade, classical pathway" EXACT [GOC:add]
is_a: GO:0006956 ! complement activation
relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0006959
name: humoral immune response
namespace: biological_process
def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
xref: Wikipedia:Humoral_immunity
is_a: GO:0006955 ! immune response

[Term]
id: GO:0006962
name: male-specific antibacterial humoral response
namespace: biological_process
def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators]
is_a: GO:0019731 ! antibacterial humoral response
is_a: GO:0050831 ! male-specific defense response to bacterium

[Term]
id: GO:0006963
name: positive regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
synonym: "activation of antibacterial peptide biosynthetic process" NARROW []
synonym: "antibacterial peptide induction" EXACT []
synonym: "antibacterial polypeptide induction" EXACT []
synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW []
synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT []
is_a: GO:0002803 ! positive regulation of antibacterial peptide production
is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0006964
name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
synonym: "anti-Gram-negative bacterial peptide induction" EXACT []
synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT []
synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process
relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0006965
name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475]
synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
synonym: "anti-Gram-positive bacterial peptide induction" EXACT []
synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT []
synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process
relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0006967
name: positive regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
synonym: "activation of antifungal peptide biosynthetic process" NARROW []
synonym: "antifungal peptide induction" EXACT []
synonym: "antifungal polypeptide induction" EXACT []
synonym: "stimulation of antifungal peptide biosynthetic process" NARROW []
synonym: "up regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "upregulation of antifungal peptide biosynthetic process" EXACT []
is_a: GO:0002804 ! positive regulation of antifungal peptide production
is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process
relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0006968
name: cellular defense response
namespace: biological_process
alt_id: GO:0002818
alt_id: GO:0016066
alt_id: GO:0016067
def: "A defense response that is mediated by cells." [GOC:ebc]
synonym: "cellular defence response" EXACT []
synonym: "intracellular defence response" NARROW []
synonym: "intracellular defense response" NARROW []
is_a: GO:0006952 ! defense response

[Term]
id: GO:0006969
name: obsolete melanotic tumor response
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it was undefined and represented an abnormal process.
synonym: "melanotic mass response" EXACT []
synonym: "melanotic tumor response" EXACT []
is_obsolete: true

[Term]
id: GO:0006970
name: response to osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]
subset: goslim_yeast
synonym: "osmotic response" EXACT []
synonym: "osmotic stress response" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0006971
name: hypotonic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, PMID:12598593]
synonym: "hypo-osmotic response" EXACT []
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0006972
name: hyperosmotic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009]
synonym: "HOG response" EXACT []
synonym: "hypertonic response" EXACT []
synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf]
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0006973
name: intracellular accumulation of glycerol
namespace: biological_process
def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666]
is_a: GO:0019725 ! cellular homeostasis
relationship: part_of GO:0071474 ! cellular hyperosmotic response

[Term]
id: GO:0006974
name: DNA damage response
namespace: biological_process
alt_id: GO:0034984
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
subset: goslim_yeast
synonym: "cellular DNA damage response" EXACT []
synonym: "cellular response to DNA damage stimulus" EXACT []
synonym: "response to DNA damage stimulus" BROAD []
synonym: "response to genotoxic stress" EXACT []
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0006977
name: obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
namespace: biological_process
def: "OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that this term is about down stream effects, not the signaling pathway itself.
synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah]
is_obsolete: true
replaced_by: GO:0030330

[Term]
id: GO:0006978
name: obsolete DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424]
comment: The reason for obsoletion is that this term is about down stream effects, not the signaling pathway itself.
is_obsolete: true
replaced_by: GO:0030330

[Term]
id: GO:0006979
name: response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
subset: goslim_yeast
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006981
name: obsolete activation of SoxR protein
namespace: biological_process
def: "OBSOLETE. The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757]
comment: This term was made obsolete because it was too specific with respect to a single gene product.
is_obsolete: true

[Term]
id: GO:0006982
name: response to lipid hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149]
synonym: "response to LHPO" EXACT []
is_a: GO:0033194 ! response to hydroperoxide
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0006983
name: ER overload response
namespace: biological_process
alt_id: GO:0006985
def: "The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516]
synonym: "endoplasmic reticulum overload response" EXACT []
synonym: "EOR" EXACT []
synonym: "EOR-mediated activation of NF-kappaB" NARROW [GOC:dph, GOC:tb]
synonym: "EOR-mediated NF-kappaB activation" NARROW []
synonym: "ER-overload response" EXACT []
synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of NF-kappaB transcription factor activity by ER overload response" NARROW []
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0006984
name: ER-nucleus signaling pathway
namespace: biological_process
def: "The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah]
synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT []
synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT []
synonym: "ER to nucleus signaling pathway" EXACT []
synonym: "ER to nucleus signalling pathway" EXACT []
synonym: "ER-nuclear signaling pathway" EXACT []
synonym: "ER-nuclear signalling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0006986
name: response to unfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]
comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER.
synonym: "heat shock protein activity" RELATED []
is_a: GO:0035966 ! response to topologically incorrect protein

[Term]
id: GO:0006987
name: obsolete activation of signaling protein activity involved in unfolded protein response
namespace: biological_process
def: "OBSOLETE. The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763]
comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498).
synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb]
synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT []
synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT []
is_obsolete: true
consider: GO:0036498

[Term]
id: GO:0006988
name: obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" EXACT []
is_obsolete: true
consider: GO:0004521

[Term]
id: GO:0006989
name: obsolete unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" EXACT []
is_obsolete: true
consider: GO:0008452

[Term]
id: GO:0006990
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
namespace: biological_process
def: "OBSOLETE. The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763]
comment: This term was obsoleted because is represents a GO-CAM model.
synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb]
synonym: "unfolded protein response, activation of target gene transcription" NARROW []
synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb]
synonym: "unfolded protein response, stimulation of target gene transcription" NARROW []
synonym: "unfolded protein response, target gene transcriptional activation" BROAD []
synonym: "unfolded protein response, up regulation of target gene transcription" EXACT []
synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT []
synonym: "unfolded protein response, upregulation of target gene transcription" EXACT []
is_obsolete: true
consider: GO:0030968
consider: GO:0034514
consider: GO:0045944

[Term]
id: GO:0006991
name: response to sterol depletion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732]
synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006995
name: cellular response to nitrogen starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0043562 ! cellular response to nitrogen levels

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
alt_id: GO:1902589
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "organelle organisation" EXACT []
synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah]
synonym: "single organism organelle organization" EXACT [GOC:TermGenie]
synonym: "single-organism organelle organization" RELATED []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT []
synonym: "nuclear organization" EXACT []
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0006998
name: nuclear envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
synonym: "nuclear envelope organisation" EXACT [GOC:mah]
synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0006997 ! nucleus organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0006999
name: nuclear pore organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah]
synonym: "nuclear pore organisation" EXACT []
synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0007000
name: nucleolus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
synonym: "nucleolus organisation" EXACT []
synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0007002
name: obsolete centromere binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "centromere binding" EXACT []
is_obsolete: true
replaced_by: GO:0019237

[Term]
id: GO:0007003
name: obsolete telomere binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "telomere binding" EXACT []
is_obsolete: true
replaced_by: GO:0042162

[Term]
id: GO:0007004
name: telomere maintenance via telomerase
namespace: biological_process
def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh]
synonym: "telomerase-dependent telomere maintenance" EXACT []
is_a: GO:0006278 ! RNA-templated DNA biosynthetic process
is_a: GO:0010833 ! telomere maintenance via telomere lengthening

[Term]
id: GO:0007005
name: mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "mitochondria organization" EXACT [GOC:mah]
synonym: "mitochondrial biogenesis" EXACT []
synonym: "mitochondrial organization" EXACT []
synonym: "mitochondrion biogenesis" EXACT []
synonym: "mitochondrion morphogenesis" RELATED []
synonym: "mitochondrion organisation" EXACT [GOC:mah]
synonym: "mitochondrion organization and biogenesis" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007006
name: mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "mitochondrial membrane organisation" EXACT []
synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0007007
name: inner mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "inner mitochondrial membrane organisation" EXACT []
synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
synonym: "mitochondrial inner membrane organization" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization

[Term]
id: GO:0007008
name: outer mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'.
synonym: "outer mitochondrial membrane organisation" EXACT []
synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007006 ! mitochondrial membrane organization

[Term]
id: GO:0007009
name: plasma membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
synonym: "plasma membrane organisation" EXACT []
synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007010
name: cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah]
synonym: "cytoskeletal regulator activity" RELATED []
synonym: "cytoskeleton organisation" EXACT []
synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007011
name: obsolete regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense.
synonym: "regulation of cytoskeleton" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0007014
name: actin ubiquitination
namespace: biological_process
def: "The modification of actin by addition of ubiquitin groups." [GOC:mah]
synonym: "indirect flight muscle actin ubiquitination" NARROW [GOC:mah]
is_a: GO:0016567 ! protein ubiquitination
is_a: GO:0030047 ! actin modification

[Term]
id: GO:0007015
name: actin filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
synonym: "actin filament organisation" EXACT []
synonym: "regulation of actin filament localization" NARROW []
is_a: GO:0097435 ! supramolecular fiber organization
relationship: part_of GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0007016
name: obsolete cytoskeletal anchoring at plasma membrane
namespace: biological_process
def: "OBSOLETE. A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytoskeletal anchoring activity" RELATED []
is_obsolete: true
consider: GO:0007010
consider: GO:0106006

[Term]
id: GO:0007017
name: microtubule-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_chembl
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007018
name: microtubule-based movement
namespace: biological_process
def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]
subset: goslim_drosophila
subset: goslim_generic
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0007019
name: microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule depolymerization during nuclear congression" NARROW []
synonym: "microtubule disassembly" EXACT []
synonym: "microtubule shortening" EXACT []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0007020
name: microtubule nucleation
namespace: biological_process
def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]
xref: Wikipedia:Microtubule_nucleation
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0046785 ! microtubule polymerization

[Term]
id: GO:0007021
name: tubulin complex assembly
namespace: biological_process
def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]
synonym: "tubulin assembly" EXACT []
synonym: "tubulin folding" RELATED []
synonym: "tubulin-specific chaperone activity" RELATED []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0007023
name: post-chaperonin tubulin folding pathway
namespace: biological_process
def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094]
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0007026
name: negative regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
synonym: "down regulation of microtubule depolymerization" EXACT []
synonym: "down-regulation of microtubule depolymerization" EXACT []
synonym: "downregulation of microtubule depolymerization" EXACT []
synonym: "inhibition of microtubule depolymerization" NARROW []
synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of microtubule disassembly" EXACT []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901880 ! negative regulation of protein depolymerization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0007027
name: negative regulation of axonemal microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah]
synonym: "axonemal microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph]
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization

[Term]
id: GO:0007028
name: cytoplasm organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "cytoplasm organisation" EXACT []
synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0007029
name: endoplasmic reticulum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "endoplasmic reticulum morphology" RELATED []
synonym: "endoplasmic reticulum organisation" EXACT []
synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah]
synonym: "ER organisation" EXACT []
synonym: "ER organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007030
name: Golgi organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "Golgi apparatus organization" EXACT []
synonym: "Golgi organisation" EXACT []
synonym: "Golgi organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007031
name: peroxisome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "peroxisome organisation" EXACT []
synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007032
name: endosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "endosome organisation" EXACT []
synonym: "endosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007033
name: vacuole organization
namespace: biological_process
alt_id: GO:0044086
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "vacuolar assembly" NARROW [GOC:mah]
synonym: "vacuole biogenesis" RELATED [GOC:mah]
synonym: "vacuole organisation" EXACT []
synonym: "vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007034
name: vacuolar transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai]
subset: goslim_chembl
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0007035
name: vacuolar acidification
namespace: biological_process
def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
is_a: GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0007036
name: vacuolar calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah]
is_a: GO:0006874 ! intracellular calcium ion homeostasis

[Term]
id: GO:0007038
name: endocytosed protein transport to vacuole
namespace: biological_process
def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai]
comment: See also the biological process term 'endocytosis ; GO:0006897'.
synonym: "delivery of endocytosed proteins to the vacuole" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007039
name: protein catabolic process in the vacuole
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw]
synonym: "vacuolar protein breakdown" RELATED []
synonym: "vacuolar protein catabolic process" RELATED []
synonym: "vacuolar protein catabolism" RELATED []
synonym: "vacuolar protein degradation" RELATED []
is_a: GO:0030163 ! protein catabolic process

[Term]
id: GO:0007040
name: lysosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
subset: goslim_generic
synonym: "lysosome organisation" EXACT []
synonym: "lysosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0080171 ! lytic vacuole organization

[Term]
id: GO:0007041
name: lysosomal transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai]
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007042
name: lysosomal lumen acidification
namespace: biological_process
def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid]
synonym: "lysosome pH reduction" EXACT [GOC:bf, GOC:rph]
is_a: GO:0007035 ! vacuolar acidification
is_a: GO:0035751 ! regulation of lysosomal lumen pH

[Term]
id: GO:0007043
name: cell-cell junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
synonym: "intercellular junction assembly" EXACT []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0007044
name: cell-substrate junction assembly
namespace: biological_process
alt_id: GO:0007045
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah]
comment: The primary label for merged term was 'cell-substrate adherens junction assembly' GO:0007045. The term was merged into the parent 'cell-substrate junction assembly', because, based on the most recent litarature, 'adherens junction' is always a 'cell-cell junction' (PMID:20571587, PMID:17854762, PMID:21422226, PMID:28096264, PMID:28401269, PMID:26923917).
synonym: "cell-substrate adherens junction assembly" RELATED []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0150115 ! cell-substrate junction organization

[Term]
id: GO:0007048
name: obsolete oncogenesis
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a pathological process.
synonym: "oncogenesis" EXACT []
is_obsolete: true

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007051
name: spindle organization
namespace: biological_process
alt_id: GO:0043146
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]
synonym: "spindle organisation" EXACT []
synonym: "spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "spindle stabilization" RELATED []
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0007052
name: mitotic spindle organization
namespace: biological_process
alt_id: GO:0000071
alt_id: GO:0030472
alt_id: GO:0043148
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]
comment: In fission yeast most mitotic spindle organization occurs in the nucleus.
synonym: "mitotic spindle organisation" EXACT []
synonym: "mitotic spindle organisation in nucleus" NARROW []
synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "mitotic spindle organization and biogenesis in cell nucleus" NARROW []
synonym: "mitotic spindle organization and biogenesis in nucleus" NARROW []
synonym: "mitotic spindle organization in nucleus" NARROW []
synonym: "mitotic spindle stabilization" RELATED []
synonym: "spindle organization and biogenesis during mitosis" EXACT []
synonym: "spindle organization and biogenesis in nucleus during mitosis" NARROW []
is_a: GO:0007051 ! spindle organization
is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis

[Term]
id: GO:0007053
name: spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
is_a: GO:0090306 ! meiotic spindle assembly
relationship: part_of GO:0007140 ! male meiotic nuclear division

[Term]
id: GO:0007054
name: spindle assembly involved in male meiosis I
namespace: biological_process
def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "male meiosis I spindle assembly" RELATED []
is_a: GO:0007053 ! spindle assembly involved in male meiosis
relationship: part_of GO:0007141 ! male meiosis I

[Term]
id: GO:0007055
name: spindle assembly involved in male meiosis II
namespace: biological_process
def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "male meiosis II spindle assembly" RELATED []
is_a: GO:0007053 ! spindle assembly involved in male meiosis
relationship: part_of GO:0007142 ! male meiosis II

[Term]
id: GO:0007056
name: spindle assembly involved in female meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiotic spindle assembly" RELATED []
is_a: GO:0090306 ! meiotic spindle assembly
relationship: part_of GO:0007143 ! female meiotic nuclear division

[Term]
id: GO:0007057
name: spindle assembly involved in female meiosis I
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiosis I spindle assembly" RELATED []
is_a: GO:0007056 ! spindle assembly involved in female meiosis
relationship: part_of GO:0007144 ! female meiosis I

[Term]
id: GO:0007058
name: spindle assembly involved in female meiosis II
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiosis II spindle assembly" RELATED []
is_a: GO:0007056 ! spindle assembly involved in female meiosis
relationship: part_of GO:0007147 ! female meiosis II

[Term]
id: GO:0007059
name: chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "chromosome division" EXACT []
synonym: "chromosome transmission" RELATED []
xref: Wikipedia:Chromosome_segregation
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0007060
name: male meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
is_a: GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0007140 ! male meiotic nuclear division

[Term]
id: GO:0007062
name: sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194]
synonym: "cohesion-mediated DNA tethering" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0007063
name: regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0033044 ! regulation of chromosome organization
relationship: regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0007064
name: mitotic sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]
is_a: GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0007065
name: male meiosis sister chromatid cohesion
namespace: biological_process
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai]
is_a: GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0007066
name: female meiosis sister chromatid cohesion
namespace: biological_process
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai]
is_a: GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0007068
name: obsolete negative regulation of transcription during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "down regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription" EXACT []
synonym: "negative regulation of transcription, mitotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0000122
consider: GO:0044772

[Term]
id: GO:0007069
name: obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "down regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription from Pol I promoter" EXACT []
synonym: "negative regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0016479
consider: GO:0044772

[Term]
id: GO:0007070
name: obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "down regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription from Pol II promoter" EXACT []
synonym: "negative regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0000122
consider: GO:0044772

[Term]
id: GO:0007071
name: obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "down regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription from Pol III promoter" EXACT []
synonym: "negative regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0016480
consider: GO:0044772

[Term]
id: GO:0007072
name: obsolete positive regulation of transcription involved in exit from mitosis
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0045893

[Term]
id: GO:0007073
name: obsolete positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW []
is_obsolete: true
consider: GO:0010458
consider: GO:0045943

[Term]
id: GO:0007074
name: obsolete positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW []
synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW []
is_obsolete: true
consider: GO:0010458
consider: GO:0045944

[Term]
id: GO:0007075
name: obsolete positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW []
synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0010458
consider: GO:0045945

[Term]
id: GO:0007076
name: mitotic chromosome condensation
namespace: biological_process
def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
is_a: GO:0030261 ! chromosome condensation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007077
name: mitotic nuclear membrane disassembly
namespace: biological_process
def: "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." [GOC:bf, PMID:32848252]
synonym: "local NEB" BROAD []
synonym: "mitotic nuclear envelope breakdown" EXACT []
synonym: "mitotic nuclear envelope catabolism" RELATED []
synonym: "mitotic nuclear envelope degradation" RELATED []
synonym: "mitotic nuclear envelope disassembly" RELATED []
synonym: "NEB" BROAD []
synonym: "nuclear envelope breakdown" BROAD []
is_a: GO:0051081 ! nuclear membrane disassembly
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:0007078
name: lamin depolymerization
namespace: biological_process
def: "The cell cycle process in which lamin is depolymerized." [GOC:jid]
is_a: GO:0051261 ! protein depolymerization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007077 ! mitotic nuclear membrane disassembly

[Term]
id: GO:0007079
name: mitotic chromosome movement towards spindle pole
namespace: biological_process
alt_id: GO:0007082
def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai]
synonym: "chromosome migration to spindle pole during mitosis" EXACT []
synonym: "chromosome movement towards spindle pole during mitosis" EXACT []
synonym: "mitotic chromosome movement" BROAD []
synonym: "mitotic chromosome movement to spindle pole" EXACT []
synonym: "mitotic sister chromosome movement towards spindle pole" EXACT []
synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT []
is_a: GO:0051305 ! chromosome movement towards spindle pole
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007080
name: mitotic metaphase chromosome alignment
namespace: biological_process
def: "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]
is_a: GO:0051310 ! metaphase chromosome alignment
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007081
name: obsolete mitotic sister-chromatid adhesion release
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes.
synonym: "mitotic sister-chromatid adhesion release" EXACT []
is_obsolete: true
consider: GO:0000070
consider: GO:0007064

[Term]
id: GO:0007083
name: obsolete mitotic chromosome decondensation
namespace: biological_process
def: "OBSOLETE. The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai]
comment: This term was obsoleted because it is a spontaneous process.
is_obsolete: true

[Term]
id: GO:0007084
name: mitotic nuclear membrane reassembly
namespace: biological_process
def: "The mitotic cell cycle process involving ESCRTIII that results in reformation of the nuclear envelope after mitotic nuclear division. In organisms undergoing closed mitosis this involves resealing or 'repair' of the nuclear envelope in the nuclear bridge." [PMID:26040712, PMID:28242692, PMID:32109380, PMID:32848252]
synonym: "mitotic nuclear envelope reassembly" RELATED []
synonym: "nuclear envelope repair" BROAD []
synonym: "nuclear envelope resealing" BROAD []
is_a: GO:0031468 ! nuclear membrane reassembly
is_a: GO:0101024 ! mitotic nuclear membrane organization

[Term]
id: GO:0007085
name: obsolete nuclear membrane vesicle binding to chromatin
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "nuclear membrane vesicle binding to chromatin" EXACT []
is_obsolete: true
consider: GO:0003682

[Term]
id: GO:0007086
name: vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly
namespace: biological_process
def: "The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly." [GOC:jid, GOC:mah]
is_a: GO:0000740 ! nuclear membrane fusion
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0101024 ! mitotic nuclear membrane organization
relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly

[Term]
id: GO:0007087
name: mitotic nuclear pore complex reassembly
namespace: biological_process
def: "The cell cycle process in which nuclear pore complexes reform during mitotic cell division." [GOC:ai]
is_a: GO:0051292 ! nuclear pore complex assembly
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly

[Term]
id: GO:0007088
name: regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "regulation of mitosis" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051783 ! regulation of nuclear division
relationship: regulates GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0007089
name: traversing start control point of mitotic cell cycle
namespace: biological_process
alt_id: GO:0000081
def: "A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity." [GOC:mtg_cell_cycle]
is_a: GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle

[Term]
id: GO:0007090
name: obsolete regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of S phase of mitotic cell cycle" EXACT []
synonym: "regulation of S-phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0044772

[Term]
id: GO:0007091
name: metaphase/anaphase transition of mitotic cell cycle
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]
synonym: "metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [GOC:vw]
synonym: "mitotic metaphase/anaphase transition" EXACT []
is_a: GO:0044772 ! mitotic cell cycle phase transition
is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle

[Term]
id: GO:0007093
name: mitotic cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0031575
alt_id: GO:0071780
alt_id: GO:0072413
alt_id: GO:0072456
alt_id: GO:0072474
def: "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
synonym: "mitotic cell cycle checkpoint" EXACT []
synonym: "mitotic checkpoint" RELATED []
synonym: "signal transduction involved in mitotic cell cycle checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cell cycle G1/S checkpoint" NARROW []
synonym: "signal transduction involved in mitotic G2/M transition checkpoint" NARROW []
is_a: GO:0000075 ! cell cycle checkpoint signaling
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:0007094
name: mitotic spindle assembly checkpoint signaling
namespace: biological_process
alt_id: GO:0044810
alt_id: GO:0072480
alt_id: GO:1902420
def: "A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]
synonym: "Dma1-dependent checkpoint" NARROW []
synonym: "Mad2-dependent checkpoint" NARROW []
synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT []
synonym: "mitotic checkpoint" EXACT []
synonym: "mitotic spindle assembly checkpoint" EXACT []
synonym: "mitotic spindle assembly checkpoint signalling" EXACT []
synonym: "SAC-independent checkpoint" NARROW []
synonym: "signal transduction involved in Dma1-dependent checkpoint" NARROW []
synonym: "signal transduction involved in mitotic cell cycle spindle assembly checkpoint" EXACT []
synonym: "signal transduction involved in mitotic spindle assembly checkpoint" EXACT []
synonym: "signal transduction involved in SAC-independent checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "signaling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "signalling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "signalling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition
is_a: GO:0071173 ! spindle assembly checkpoint signaling
is_a: GO:0071174 ! mitotic spindle checkpoint signaling

[Term]
id: GO:0007095
name: mitotic G2 DNA damage checkpoint signaling
namespace: biological_process
alt_id: GO:0031572
alt_id: GO:0072425
alt_id: GO:0072434
alt_id: GO:1902504
alt_id: GO:1902505
alt_id: GO:1902506
def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]
synonym: "down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "G2 DNA damage checkpoint" RELATED []
synonym: "G2/M transition DNA damage checkpoint" EXACT []
synonym: "inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "mitotic cell cycle G2/M transition DNA damage checkpoint" EXACT []
synonym: "mitotic G2 DNA damage checkpoint" EXACT []
synonym: "negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW []
synonym: "negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW []
synonym: "positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW []
synonym: "regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "signal transduction involved in G2 DNA damage checkpoint" EXACT []
synonym: "signal transduction involved in G2/M transition DNA damage checkpoint" EXACT []
synonym: "signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT []
synonym: "signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT []
is_a: GO:0044773 ! mitotic DNA damage checkpoint signaling
is_a: GO:0044818 ! mitotic G2/M transition checkpoint

[Term]
id: GO:0007096
name: regulation of exit from mitosis
namespace: biological_process
def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
relationship: regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0007097
name: nuclear migration
namespace: biological_process
alt_id: GO:0040023
def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai]
synonym: "establishment of cell nucleus localization" RELATED []
synonym: "establishment of localization of nucleus" RELATED []
synonym: "establishment of nucleus localisation" RELATED [GOC:mah]
synonym: "establishment of nucleus localization" RELATED []
synonym: "establishment of position of nucleus" EXACT []
synonym: "nuclear movement" EXACT []
synonym: "nuclear positioning" EXACT []
synonym: "nucleus migration" EXACT []
synonym: "nucleus positioning" EXACT []
synonym: "positioning of nucleus" EXACT []
is_a: GO:0046907 ! intracellular transport
is_a: GO:0051647 ! nucleus localization
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0007098
name: centrosome cycle
namespace: biological_process
alt_id: GO:0051297
def: "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
synonym: "centrosome organisation" EXACT []
synonym: "centrosome organization" EXACT []
synonym: "centrosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0007099
name: centriole replication
namespace: biological_process
alt_id: GO:0032054
def: "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]
synonym: "centriole duplication" EXACT []
synonym: "ciliary basal body duplication" RELATED []
synonym: "microtubule basal body duplication" BROAD []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0098534 ! centriole assembly
relationship: part_of GO:0051298 ! centrosome duplication

[Term]
id: GO:0007100
name: mitotic centrosome separation
namespace: biological_process
def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
is_a: GO:0051299 ! centrosome separation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0007101
name: obsolete male meiosis centrosome cycle
namespace: biological_process
def: "OBSOLETE. Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism." [GOC:mah]
comment: false
synonym: "centrosome cycle involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0007105
name: cytokinesis, division site positioning
namespace: biological_process
alt_id: GO:0010687
def: "The process in which a contractile ring is positioned in a specific location. This process is critical for both for both symmetric and asymmetric cell divisions." [PMID:26553932, PMID:28162898]
synonym: "contractile ring localization" RELATED []
synonym: "cytokinesis, site selection" EXACT []
synonym: "division plane positioning" EXACT []
synonym: "site selection involved in cell cycle cytokinesis" EXACT []
synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process

[Term]
id: GO:0007106
name: obsolete cytokinesis, protein recruitment
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was not defined.
synonym: "cytokinesis, protein recruitment" EXACT []
is_obsolete: true

[Term]
id: GO:0007107
name: membrane addition at site of cytokinesis
namespace: biological_process
def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt]
synonym: "cytokinesis, membrane recruitment/generation" EXACT []
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0007108
name: obsolete cytokinesis, initiation of separation
namespace: biological_process
def: "OBSOLETE. The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb]
comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate.
synonym: "cytokinesis, initiation of separation" EXACT []
synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0007109
name: obsolete cytokinesis, completion of separation
namespace: biological_process
def: "OBSOLETE. The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb]
comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate.
synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
synonym: "cytokinesis, completion of separation" EXACT []
is_obsolete: true

[Term]
id: GO:0007110
name: meiosis I cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cytokinesis after meiosis I" EXACT []
is_a: GO:0033206 ! meiotic cytokinesis
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0007111
name: meiosis II cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cytokinesis after meiosis II" EXACT []
is_a: GO:0033206 ! meiotic cytokinesis
is_a: GO:0061983 ! meiosis II cell cycle process

[Term]
id: GO:0007112
name: male meiosis cytokinesis
namespace: biological_process
def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb]
synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0033206 ! meiotic cytokinesis
relationship: part_of GO:0007140 ! male meiotic nuclear division

[Term]
id: GO:0007113
name: endomitotic cell cycle
namespace: biological_process
def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins.
synonym: "endomitosis" RELATED []
xref: Wikipedia:Mitosis#Endomitosis
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007114
name: cell budding
namespace: biological_process
def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_yeast
synonym: "budding" BROAD []
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0051301 ! cell division

[Term]
id: GO:0007115
name: obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents two processes.
synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0000282
consider: GO:0030010

[Term]
id: GO:0007116
name: regulation of cell budding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah]
synonym: "regulation of budding" BROAD []
is_a: GO:0051302 ! regulation of cell division
is_a: GO:1903664 ! regulation of asexual reproduction
relationship: regulates GO:0007114 ! cell budding

[Term]
id: GO:0007117
name: budding cell bud growth
namespace: biological_process
def: "The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators]
synonym: "bud growth" BROAD []
is_a: GO:0040007 ! growth
relationship: part_of GO:0007114 ! cell budding

[Term]
id: GO:0007118
name: budding cell apical bud growth
namespace: biological_process
def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators]
synonym: "apical bud growth" BROAD []
is_a: GO:0007117 ! budding cell bud growth

[Term]
id: GO:0007119
name: budding cell isotropic bud growth
namespace: biological_process
def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators]
synonym: "isotropic bud growth" BROAD []
is_a: GO:0007117 ! budding cell bud growth

[Term]
id: GO:0007120
name: axial cellular bud site selection
namespace: biological_process
def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt]
synonym: "axial bud site selection" EXACT []
synonym: "axial budding" BROAD []
is_a: GO:0000282 ! cellular bud site selection
is_a: GO:0007114 ! cell budding

[Term]
id: GO:0007121
name: bipolar cellular bud site selection
namespace: biological_process
def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt]
synonym: "bipolar bud site selection" EXACT []
synonym: "bipolar budding" BROAD []
synonym: "polar budding" BROAD []
is_a: GO:0000282 ! cellular bud site selection
is_a: GO:0007114 ! cell budding

[Term]
id: GO:0007122
name: obsolete loss of asymmetric budding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a phenotype rather than a biological process.
synonym: "loss of asymmetric budding" EXACT []
is_obsolete: true
consider: GO:0006033

[Term]
id: GO:0007123
name: obsolete bud scar accumulation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a phenotype rather than a biological process.
synonym: "bud scar accumulation" EXACT []
is_obsolete: true
consider: GO:0000282

[Term]
id: GO:0007124
name: pseudohyphal growth
namespace: biological_process
def: "The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli." [GOC:krc, PMID:11104818, PMID:19347739, PMID:24710476]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0016049 ! cell growth
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0007125
name: obsolete invasive growth
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it has been split into two new terms.
synonym: "invasive growth" EXACT []
is_obsolete: true
consider: GO:0001403
consider: GO:0044409

[Term]
id: GO:0007127
name: meiosis I
namespace: biological_process
def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324]
synonym: "meiosis I nuclear division" EXACT []
xref: Wikipedia:Meiosis#Meiosis_I
is_a: GO:0061982 ! meiosis I cell cycle process
is_a: GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0007128
name: meiotic prophase I
namespace: biological_process
def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007129
name: homologous chromosome pairing at meiosis
namespace: biological_process
def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]
synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "chromosomal synapsis" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "synapsis" NARROW []
xref: Wikipedia:Synapsis
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0007130
name: synaptonemal complex assembly
namespace: biological_process
def: "The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]
synonym: "synaptonemal complex formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:0070193 ! synaptonemal complex organization
relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis

[Term]
id: GO:0007131
name: reciprocal meiotic recombination
namespace: biological_process
alt_id: GO:0000021
alt_id: GO:0007145
def: "The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
synonym: "female meiotic recombination" NARROW []
synonym: "gene conversion with reciprocal crossover" EXACT []
is_a: GO:0140527 ! reciprocal homologous recombination
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007132
name: meiotic metaphase I
namespace: biological_process
def: "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0051323 ! metaphase
relationship: part_of GO:0051327 ! meiotic M phase

[Term]
id: GO:0007133
name: meiotic anaphase I
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0051322 ! anaphase
relationship: part_of GO:0051327 ! meiotic M phase

[Term]
id: GO:0007134
name: meiotic telophase I
namespace: biological_process
def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007135
name: meiosis II
namespace: biological_process
def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684]
synonym: "meiosis II nuclear division" EXACT []
xref: Wikipedia:Meiosis#Meiosis_II
is_a: GO:0061983 ! meiosis II cell cycle process
is_a: GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0007136
name: meiotic prophase II
namespace: biological_process
def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007137
name: meiotic metaphase II
namespace: biological_process
def: "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051323 ! metaphase
is_a: GO:0098765 ! meiosis II cell cycle phase
relationship: part_of GO:0051327 ! meiotic M phase

[Term]
id: GO:0007138
name: meiotic anaphase II
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098765 ! meiosis II cell cycle phase
relationship: part_of GO:0051322 ! anaphase
relationship: part_of GO:0051327 ! meiotic M phase

[Term]
id: GO:0007139
name: meiotic telophase II
namespace: biological_process
def: "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007140
name: male meiotic nuclear division
namespace: biological_process
def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw]
synonym: "male meiosis" RELATED []
synonym: "male nuclear division" BROAD []
is_a: GO:0140013 ! meiotic nuclear division
relationship: part_of GO:0048232 ! male gamete generation

[Term]
id: GO:0007141
name: male meiosis I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
synonym: "male meiosis I nuclear division" EXACT []
is_a: GO:0007127 ! meiosis I
is_a: GO:0007140 ! male meiotic nuclear division

[Term]
id: GO:0007142
name: male meiosis II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah]
synonym: "male meiosis II nuclear division" EXACT []
is_a: GO:0007135 ! meiosis II
is_a: GO:0007140 ! male meiotic nuclear division

[Term]
id: GO:0007143
name: female meiotic nuclear division
namespace: biological_process
def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw]
comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'.
synonym: "female meiosis" BROAD []
synonym: "female meiotic division" BROAD []
is_a: GO:0140013 ! meiotic nuclear division
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0007144
name: female meiosis I
namespace: biological_process
def: "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah]
synonym: "female meiosis I nuclear division" EXACT []
is_a: GO:0007127 ! meiosis I
is_a: GO:0007143 ! female meiotic nuclear division

[Term]
id: GO:0007146
name: meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324]
is_a: GO:0000707 ! meiotic DNA recombinase assembly

[Term]
id: GO:0007147
name: female meiosis II
namespace: biological_process
def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah]
synonym: "female meiosis II nuclear division" EXACT []
is_a: GO:0007135 ! meiosis II
is_a: GO:0007143 ! female meiotic nuclear division

[Term]
id: GO:0007149
name: obsolete colony morphology
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it describes a phenotype rather than a biological goal.
synonym: "colony morphology" EXACT []
is_obsolete: true

[Term]
id: GO:0007150
name: obsolete growth pattern
namespace: biological_process
def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jid]
comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process.
synonym: "growth pattern" EXACT []
is_obsolete: true
consider: GO:0040007

[Term]
id: GO:0007154
name: cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
subset: goslim_pir
subset: goslim_plant
xref: Wikipedia:Cell_signaling
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
alt_id: GO:0098602
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cell adhesion molecule activity" RELATED []
synonym: "single organism cell adhesion" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007156
name: homophilic cell adhesion via plasma membrane adhesion molecules
namespace: biological_process
def: "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0007157
name: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
namespace: biological_process
def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
synonym: "agglutination" RELATED [GOC:mah]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0007158
name: neuron cell-cell adhesion
namespace: biological_process
def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators]
synonym: "neuron adhesion" EXACT []
synonym: "neuronal cell adhesion" EXACT []
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0007159
name: leukocyte cell-cell adhesion
namespace: biological_process
def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators]
synonym: "leukocyte adhesion" EXACT []
synonym: "leukocyte cell adhesion" EXACT []
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0007160
name: cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]
is_a: GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0007161
name: calcium-independent cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-independent cell adhesion molecule activity" RELATED []
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0007162
name: negative regulation of cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "cell adhesion receptor inhibitor activity" RELATED []
synonym: "down regulation of cell adhesion" EXACT []
synonym: "down-regulation of cell adhesion" EXACT []
synonym: "downregulation of cell adhesion" EXACT []
synonym: "inhibition of cell adhesion" NARROW []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0007163
name: establishment or maintenance of cell polarity
namespace: biological_process
alt_id: GO:0030012
alt_id: GO:0030467
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cell polarity" RELATED [GOC:mah, GOC:vw]
synonym: "establishment and/or maintenance of cell polarity" RELATED []
synonym: "establishment and/or maintenance of cell polarization" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007164
name: establishment of tissue polarity
namespace: biological_process
def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0007165
name: signal transduction
namespace: biological_process
alt_id: GO:0023014
alt_id: GO:0023015
alt_id: GO:0023016
alt_id: GO:0023033
alt_id: GO:0023045
def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "signaling cascade" NARROW []
synonym: "signaling pathway" RELATED []
synonym: "signalling cascade" NARROW []
synonym: "signalling pathway" RELATED []
xref: Wikipedia:Signal_transduction
is_a: GO:0009987 ! cellular process
is_a: GO:0050794 ! regulation of cellular process
relationship: part_of GO:0007154 ! cell communication
relationship: part_of GO:0023052 ! signaling
relationship: part_of GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0007166
name: cell surface receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]
subset: goslim_drosophila
synonym: "cell surface receptor linked signal transduction" EXACT []
synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf]
synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0007167
name: enzyme-linked receptor protein signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194]
synonym: "enzyme linked receptor protein signaling pathway" EXACT []
synonym: "enzyme linked receptor protein signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007168
name: receptor guanylyl cyclase signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]
synonym: "receptor guanylyl cyclase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme-linked receptor protein signaling pathway

[Term]
id: GO:0007169
name: cell surface receptor protein tyrosine kinase signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
synonym: "transmembrane receptor protein serine/threonine kinase signaling pathway" BROAD []
synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme-linked receptor protein signaling pathway

[Term]
id: GO:0007170
name: obsolete transmembrane receptor protein tyrosine kinase ligand binding
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "transmembrane receptor protein tyrosine kinase ligand binding" EXACT []
is_obsolete: true
consider: GO:0030971

[Term]
id: GO:0007171
name: activation of transmembrane receptor protein tyrosine kinase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb]
synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung]
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0007172
name: signal complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862]
synonym: "signal complex formation" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0007173
name: epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]
synonym: "EGF receptor signaling pathway" EXACT []
synonym: "EGF receptor signalling pathway" EXACT []
synonym: "EGFR signaling pathway" EXACT []
synonym: "epidermal growth factor receptor signalling pathway" EXACT []
synonym: "ERBB1 signaling pathway" EXACT [PR:000006933]
synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT [PR:000006933]
is_a: GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:0007174
name: epidermal growth factor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor." [GOC:bf, GOC:signaling, PMID:2985587]
comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
synonym: "EGF breakdown" EXACT [GOC:bf]
synonym: "EGF catabolism" EXACT [GOC:bf]
synonym: "EGF receptor ligand processing" RELATED [GOC:bf]
synonym: "epidermal growth factor breakdown" EXACT [GOC:bf]
synonym: "epidermal growth factor catabolism" EXACT [GOC:bf]
synonym: "epidermal growth factor ligand processing" RELATED [GOC:bf]
synonym: "intracellular EGF processing" RELATED [PMID:2985587]
synonym: "receptor-mediated EGF processing" RELATED [PMID:1683723]
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway

[Term]
id: GO:0007175
name: negative regulation of epidermal growth factor-activated receptor activity
namespace: biological_process
alt_id: GO:0007177
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of epidermal growth factor receptor activity" EXACT []
synonym: "down-regulation of epidermal growth factor receptor activity" EXACT []
synonym: "downregulation of epidermal growth factor receptor activity" EXACT []
synonym: "EGF receptor downregulation" EXACT []
synonym: "inhibition of epidermal growth factor receptor activity" NARROW []
synonym: "negative regulation of EGF receptor activity" EXACT []
synonym: "negative regulation of EGFR activity" EXACT []
synonym: "negative regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity
is_a: GO:2000272 ! negative regulation of signaling receptor activity

[Term]
id: GO:0007176
name: regulation of epidermal growth factor-activated receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of EGF-activated receptor activity." [GOC:dph, GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "regulation of EGF receptor activity" EXACT []
synonym: "regulation of EGFR activity" EXACT []
synonym: "regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity

[Term]
id: GO:0007178
name: cell surface receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "transmembrane receptor protein serine/threonine kinase signaling pathway" BROAD []
synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme-linked receptor protein signaling pathway

[Term]
id: GO:0007179
name: transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "TGF-beta receptor signaling pathway" EXACT []
synonym: "TGF-beta receptor signalling pathway" EXACT []
synonym: "TGFbeta receptor signaling pathway" EXACT []
synonym: "TGFbeta receptor signalling pathway" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway" EXACT []
is_a: GO:0141091 ! transforming growth factor beta receptor superfamily signaling pathway
relationship: part_of GO:0071560 ! cellular response to transforming growth factor beta stimulus

[Term]
id: GO:0007180
name: obsolete transforming growth factor beta ligand binding to type II receptor
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function.
synonym: "TGF-beta ligand binding to type II receptor" EXACT []
synonym: "TGFbeta ligand binding to type II receptor" EXACT []
synonym: "transforming growth factor beta ligand binding to type II receptor" EXACT []
is_obsolete: true
consider: GO:0005026
consider: GO:0005160
consider: GO:0050431

[Term]
id: GO:0007181
name: transforming growth factor beta receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Wikipedia:TGF_beta_signaling_pathway]
synonym: "TGF-beta receptor complex assembly" EXACT []
synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT []
synonym: "TGFbeta receptor complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0007182
name: obsolete common-partner SMAD protein phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782]
comment: This term was obsoleted because it represents a molecular function.
synonym: "co-SMAD protein phosphorylation" EXACT [GOC:rl]
synonym: "common mediator SMAD protein phosphorylation" EXACT []
synonym: "common partner SMAD protein phosphorylation" EXACT [GOC:rl]
synonym: "common-mediator SMAD protein phosphorylation" EXACT [GOC:rl]
is_obsolete: true
consider: GO:0004672
consider: GO:0060391
consider: GO:0060395

[Term]
id: GO:0007183
name: obsolete SMAD protein complex assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete]
comment: This term was obsoleted because it represents a readout for SMAD protein signal transduction ; GO:0060395.
synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020]
is_obsolete: true
consider: GO:0060395

[Term]
id: GO:0007185
name: cell surface receptor protein tyrosine phosphatase signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "transmembrane receptor protein tyrosine phosphatase signaling pathway" EXACT []
synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme-linked receptor protein signaling pathway

[Term]
id: GO:0007186
name: G protein-coupled receptor signaling pathway
namespace: biological_process
alt_id: GO:0038042
def: "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
subset: goslim_drosophila
synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW []
synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah]
synonym: "G protein coupled receptor protein signaling pathway" EXACT []
synonym: "G protein coupled receptor protein signalling pathway" EXACT []
synonym: "G-protein coupled receptor protein signal transduction" EXACT []
synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf]
synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf]
synonym: "G-protein coupled receptor signalling pathway" EXACT []
synonym: "G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "GPCR signaling pathway" EXACT []
synonym: "GPCR signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0007187
name: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, GOC:signaling, ISBN:0815316194]
synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "G-protein signaling, coupled to cyclic nucleotide second messenger" EXACT [GOC:signaling]
synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "GPCR signaling pathway via cyclic nucleotide second messenger" EXACT [GOC:signaling]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0007188
name: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway ; GO:0010578.
synonym: "adenylate cyclase-modulating GPCR signaling pathway" EXACT [GOC:signaling]
synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G-protein signaling, coupled to cAMP nucleotide second messenger" EXACT [GOC:signaling]
synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "GPCR signaling pathway via cAMP second messenger" EXACT [GOC:signaling]
synonym: "GPCR signaling pathway via modulation of adenylate cyclase activity" EXACT [GOC:signaling]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0007189
name: adenylate cyclase-activating G protein-coupled receptor signaling pathway
namespace: biological_process
alt_id: GO:0010579
alt_id: GO:0010580
def: "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
comment: This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway.
synonym: "activation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:bf]
synonym: "activation of adenylate cyclase activity involved in G-protein signaling" RELATED [GOC:signaling]
synonym: "adenylate cyclase-activating GPCR signaling pathway" EXACT [GOC:signaling]
synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT []
synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT []
synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT []
synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT []
synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT []
synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT []
synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT []
synonym: "GPCR signaling pathway via activation of adenylate cyclase" EXACT [GOC:bf]
synonym: "GPCR signaling pathway via activation of adenylate cyclase activity" EXACT [GOC:signaling]
synonym: "positive regulation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling]
synonym: "positive regulation of adenylate cyclase activity by G-protein signalling pathway" RELATED [GOC:mah]
synonym: "positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway

[Term]
id: GO:0007190
name: activation of adenylate cyclase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb]
synonym: "adenylate cyclase activator" RELATED []
synonym: "adenylyl cyclase activation" EXACT []
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity

[Term]
id: GO:0007191
name: adenylate cyclase-activating dopamine receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling]
synonym: "activation of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" RELATED [GOC:mah]
synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT []
is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway
is_a: GO:0007212 ! G protein-coupled dopamine receptor signaling pathway

[Term]
id: GO:0007192
name: adenylate cyclase-activating serotonin receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah]
synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb]
synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT []
is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway
is_a: GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0007193
name: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.
synonym: "adenylate cyclase-inhibiting GPCR signaling pathway" EXACT [GOC:signaling]
synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "GPCR signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling]
is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway

[Term]
id: GO:0007194
name: negative regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "adenylate cyclase inhibitor" RELATED []
synonym: "down regulation of adenylate cyclase activity" EXACT []
synonym: "down-regulation of adenylate cyclase activity" EXACT []
synonym: "downregulation of adenylate cyclase activity" EXACT []
synonym: "inhibition of adenylate cyclase activity" NARROW []
synonym: "negative regulation of adenylyl cyclase activity" EXACT []
is_a: GO:0031280 ! negative regulation of cyclase activity
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0051350 ! negative regulation of lyase activity

[Term]
id: GO:0007195
name: adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
is_a: GO:0007212 ! G protein-coupled dopamine receptor signaling pathway

[Term]
id: GO:0007196
name: adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway" EXACT []
synonym: "inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf]
synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah]
synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT []
is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway

[Term]
id: GO:0007197
name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf]
synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" RELATED [GOC:mah]
synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT []
is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway

[Term]
id: GO:0007198
name: adenylate cyclase-inhibiting serotonin receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by serotonin receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah]
synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" RELATED []
is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway

[Term]
id: GO:0007199
name: G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger" EXACT []
synonym: "G-protein signaling, coupled to cGMP nucleotide second messenger" EXACT [GOC:signaling]
synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "GPCR signaling pathway via activation of guanylate cyclase activity" EXACT [GOC:signaling]
synonym: "GPCR signaling pathway via cGMP second messenger" EXACT [GOC:signaling]
synonym: "guanylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [GOC:signaling]
is_a: GO:0007187 ! G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

[Term]
id: GO:0007200
name: phospholipase C-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
synonym: "activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:signaling]
synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:signaling]
synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT []
synonym: "PLC-activating GPCR signaling pathway" EXACT [GOC:signaling]
synonym: "protein kinase C-activating G protein-coupled receptor signaling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0007201
name: obsolete G-protein dissociation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about.
synonym: "G-protein dissociation" EXACT []
is_obsolete: true

[Term]
id: GO:0007202
name: obsolete activation of phospholipase C activity
namespace: biological_process
def: "OBSOLETE. The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]
comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'.\nThe reason for obsoletion is that this term represents a molecular function.
synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0007203
name: obsolete phosphatidylinositol-4,5-bisphosphate hydrolysis
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because hydrolysis is a reaction, not a process.
synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" EXACT []
is_obsolete: true
consider: GO:0004435

[Term]
id: GO:0007204
name: positive regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai]
synonym: "cytoplasmic calcium ion concentration elevation" BROAD []
synonym: "cytosolic calcium ion concentration elevation" EXACT []
synonym: "elevation of calcium ion concentration in cytoplasm" BROAD []
synonym: "elevation of calcium ion concentration in cytosol" EXACT []
synonym: "elevation of cytoplasmic calcium ion concentration" BROAD []
synonym: "elevation of cytosolic calcium ion concentration" EXACT []
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0007205
name: obsolete protein kinase C-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]
comment: This term was obsoleted because it represents the same pathway as phospholipase C-activating G protein-coupled receptor signaling pathway ; GO:0007200.
synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling]
synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" RELATED [GOC:mah]
synonym: "protein kinase C-activating G-protein coupled receptor signaling pathway" EXACT []
is_obsolete: true
replaced_by: GO:0007200

[Term]
id: GO:0007206
name: phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
namespace: biological_process
def: "A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway" RELATED [GOC:bf]
synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" RELATED [GOC:mah]
synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
synonym: "phospholipase C-activating G-protein coupled glutamate receptor signaling pathway" RELATED []
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway

[Term]
id: GO:0007207
name: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
namespace: biological_process
def: "A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf]
synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah]
synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
synonym: "muscarinic receptor signaling pathway via activation of PLC" EXACT [GOC:signaling]
synonym: "phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway" EXACT []
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway

[Term]
id: GO:0007208
name: phospholipase C-activating serotonin receptor signaling pathway
namespace: biological_process
def: "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by serotonin receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" RELATED [GOC:mah]
synonym: "serotonin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway

[Term]
id: GO:0007209
name: phospholipase C-activating tachykinin receptor signaling pathway
namespace: biological_process
def: "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by tachykinin receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" RELATED [GOC:mah]
synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0007217 ! tachykinin receptor signaling pathway

[Term]
id: GO:0007210
name: serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "serotonin receptor signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:1903351 ! cellular response to dopamine

[Term]
id: GO:0007211
name: octopamine or tyramine signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by octopamine or tyramine binding to their receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, and ending with the regulation of a downstream cellular process. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245]
synonym: "octopamine or tyramine signalling pathway" EXACT [GOC:mah]
synonym: "octopamine/tyramine signaling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0007212
name: G protein-coupled dopamine receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [PMID:36757901]
synonym: "dopamine receptor signalling pathway" BROAD []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
relationship: part_of GO:1903351 ! cellular response to dopamine

[Term]
id: GO:0007213
name: G protein-coupled acetylcholine receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194]
synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT []
synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT []
synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0095500 ! acetylcholine receptor signaling pathway

[Term]
id: GO:0007214
name: gamma-aminobutyric acid signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell." [GOC:mah]
synonym: "4-aminobutanoate signaling pathway" EXACT []
synonym: "4-aminobutanoate signalling pathway" EXACT []
synonym: "4-aminobutyrate signaling pathway" EXACT []
synonym: "4-aminobutyrate signalling pathway" EXACT []
synonym: "GABA signaling pathway" EXACT []
synonym: "GABA signalling pathway" EXACT []
synonym: "gamma-aminobutyric acid signalling pathway" EXACT []
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0007215
name: glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252]
synonym: "glutamate signaling pathway" EXACT [GOC:bf]
synonym: "glutamate signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007216
name: G protein-coupled glutamate receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling, PMID:9131252]
synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT []
synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf]
synonym: "metabotropic glutamate receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0007215 ! glutamate receptor signaling pathway

[Term]
id: GO:0007217
name: tachykinin receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2)." [GOC:mah, PMID:14723970]
synonym: "tachykinin signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0007218
name: neuropeptide signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]
synonym: "neuropeptide signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0007219
name: Notch signaling pathway
namespace: biological_process
alt_id: GO:0030179
def: "The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
synonym: "N signaling pathway" EXACT []
synonym: "N signalling pathway" EXACT []
synonym: "Notch receptor signaling pathway" EXACT []
synonym: "Notch receptor signalling pathway" EXACT []
synonym: "Notch signalling pathway" EXACT []
synonym: "Notch-receptor signaling pathway" EXACT []
synonym: "Notch-receptor signalling pathway" EXACT []
xref: Wikipedia:Notch_signaling_pathway
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007220
name: Notch receptor processing
namespace: biological_process
def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
synonym: "N receptor processing" EXACT []
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0007221
name: positive regulation of transcription of Notch receptor target
namespace: biological_process
def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094]
synonym: "N receptor target transcription factor activation" RELATED []
synonym: "Notch receptor target transcription factor activation" RELATED []
is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II
relationship: part_of GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0007223
name: Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface of a target cell leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [PMID:11532397, PMID:37804416]
synonym: "frizzled-2 signaling pathway" NARROW []
synonym: "frizzled-2 signalling pathway" NARROW []
synonym: "non-canonical Wnt signaling pathway" BROAD []
synonym: "Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
is_a: GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:0007224
name: smoothened signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]
synonym: "hedgehog signaling pathway" EXACT []
synonym: "hh signaling pathway" NARROW []
synonym: "hh signalling pathway" NARROW []
synonym: "Shh signaling pathway" RELATED [GOC:dph]
synonym: "smoothened signalling pathway" EXACT []
synonym: "Sonic hedgehog signaling pathway" NARROW [GOC:dph]
xref: Wikipedia:Hedgehog_signaling_pathway
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007225
name: patched ligand maturation
namespace: biological_process
def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups." [PMID:15057936]
synonym: "Hedgehog protein processing" NARROW []
synonym: "hh protein processing" EXACT []
synonym: "patched ligand processing" RELATED []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0007227
name: obsolete signal transduction downstream of smoothened
namespace: biological_process
def: "OBSOLETE. The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936]
comment: This term was obsoleted because it represents the same pathway as smoothened signaling pathway ; GO:0007224.
is_obsolete: true
replaced_by: GO:0007224

[Term]
id: GO:0007228
name: obsolete positive regulation of hh target transcription factor activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936]
comment: This term was obsoleted because it represents a readout.
synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of hedgehog target transcription factor" EXACT [GOC:bf, GOC:ecd]
is_obsolete: true
replaced_by: GO:0007224

[Term]
id: GO:0007229
name: integrin-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "integrin-mediated signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007230
name: obsolete calcium-o-sensing receptor pathway
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it does not make sense.
synonym: "calcium-o-sensing receptor pathway" EXACT []
is_obsolete: true
consider: GO:0019722

[Term]
id: GO:0007231
name: osmosensory signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl]
synonym: "osmolarity sensing" EXACT []
synonym: "osmolarity sensing signaling pathway" EXACT []
synonym: "osmolarity sensing signalling pathway" EXACT []
synonym: "osmosensory signal transduction" EXACT [GOC:signaling]
synonym: "osmosensory signalling pathway" EXACT []
synonym: "signal transduction during osmotic stress" EXACT []
is_a: GO:0035556 ! intracellular signal transduction
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0007232
name: osmosensory signaling pathway via Sho1 osmosensor
namespace: biological_process
def: "The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl, PMID:26787842]
synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT []
synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT []
is_a: GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0007234
name: osmosensory signaling via phosphorelay pathway
namespace: biological_process
def: "The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. In S.cerevisiae, the osmosensor is the histidine kinase Sln1." [PMID:26787842, PMID:9843501]
synonym: "osmolarity sensing via two-component system" EXACT []
synonym: "osmolarity signaling pathway via two-component system" EXACT []
synonym: "osmolarity signalling pathway via two-component system" EXACT []
synonym: "osmosensory signaling pathway via two-component system" NARROW []
synonym: "osmosensory signalling pathway via two-component system" EXACT []
synonym: "signal transduction during osmotic stress via two-component system" EXACT []
is_a: GO:0000160 ! phosphorelay signal transduction system
is_a: GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0007235
name: obsolete activation of Ypd1 protein
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Ypd1 protein" EXACT []
is_obsolete: true

[Term]
id: GO:0007236
name: obsolete activation of Ssk1 protein
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Ssk1 protein" EXACT []
is_obsolete: true

[Term]
id: GO:0007237
name: obsolete activation of Ssk2/Ssk22 proteins
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Ssk2/Ssk22 proteins" EXACT []
is_obsolete: true

[Term]
id: GO:0007238
name: obsolete activation of Pbs2
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Pbs2" EXACT []
is_obsolete: true

[Term]
id: GO:0007239
name: obsolete activation of Hog1
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Hog1" EXACT []
is_obsolete: true

[Term]
id: GO:0007240
name: obsolete nuclear translocation of Hog1
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "nuclear translocation of Hog1" EXACT []
is_obsolete: true

[Term]
id: GO:0007241
name: obsolete inactivation of Hog1
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "inactivation of Hog1" EXACT []
is_obsolete: true

[Term]
id: GO:0007244
name: obsolete MAPKKK cascade (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007245
name: obsolete activation of MAPKKK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007246
name: obsolete activation of MAPKK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007247
name: obsolete activation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0000750

[Term]
id: GO:0007248
name: obsolete nuclear translocation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007249
name: canonical NF-kappaB signal transduction
namespace: biological_process
def: "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]
synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf]
synonym: "I-kappaB kinase/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling]
synonym: "I-kappaB kinase/NF-kappaB signaling" EXACT []
synonym: "NF-kappaB cascade" BROAD []
synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232]
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0007250
name: activation of NF-kappaB-inducing kinase activity
namespace: biological_process
def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372]
subset: gocheck_obsoletion_candidate
synonym: "activation of NIK activity" EXACT [GOC:bf]
synonym: "positive regulation of NF-kappaB-inducing kinase activity" BROAD []
is_a: GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0038061 ! non-canonical NF-kappaB signal transduction

[Term]
id: GO:0007251
name: obsolete activation of the inhibitor of kappa kinase
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its meaning was unclear.
synonym: "activation of the inhibitor of kappa kinase" EXACT []
is_obsolete: true
consider: GO:0007249

[Term]
id: GO:0007252
name: I-kappaB phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468]
subset: gocheck_obsoletion_candidate
synonym: "IkappaB phosphorylation" EXACT [GOC:bf]
synonym: "IKB phosphorylation" EXACT [GOC:bf]
synonym: "inhibitor of kappaB phosphorylation" EXACT [GOC:bf]
synonym: "inhibitor of NF-kappaB phosphorylation" EXACT [GOC:bf]
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0007249 ! canonical NF-kappaB signal transduction

[Term]
id: GO:0007253
name: obsolete cytoplasmic sequestering of NF-kappaB
namespace: biological_process
def: "OBSOLETE. The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "cytoplasmic NF-kappaB retention" EXACT []
synonym: "cytoplasmic NF-kappaB sequestration" EXACT []
synonym: "cytoplasmic NF-kappaB storage" EXACT []
synonym: "cytoplasmic retention of NF-kappaB" EXACT []
synonym: "cytoplasmic sequestration of NF-kappaB" EXACT []
synonym: "cytoplasmic storage of NF-kappaB" EXACT []
synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0140311

[Term]
id: GO:0007254
name: JNK cascade
namespace: biological_process
def: "A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017]
synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974]
synonym: "JNK1 cascade" NARROW [GOC:add]
synonym: "JNK2 cascade" NARROW [GOC:add]
synonym: "JNK3 cascade" NARROW [GOC:add]
synonym: "MAPK10 cascade" NARROW [GOC:add]
synonym: "MAPK8 cascade" EXACT [GOC:add]
synonym: "MAPK9 cascade" NARROW [GOC:add]
synonym: "SAPK cascade" BROAD []
synonym: "stress-activated protein kinase cascade" BROAD []
is_a: GO:0000165 ! MAPK cascade

[Term]
id: GO:0007256
name: obsolete activation of JNKK activity
namespace: biological_process
def: "OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of JUN kinase kinase activity" EXACT []
synonym: "positive regulation of JUNKK activity" BROAD []
is_obsolete: true
consider: GO:0043539
consider: GO:0046328

[Term]
id: GO:0007257
name: obsolete activation of JUN kinase activity
namespace: biological_process
def: "OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase (JNK)." [GOC:bf]
synonym: "activation of SAPK activity" BROAD []
is_obsolete: true
consider: GO:0007254
consider: GO:0043539

[Term]
id: GO:0007258
name: JUN phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0007254 ! JNK cascade

[Term]
id: GO:0007259
name: cell surface receptor signaling pathway via JAK-STAT
namespace: biological_process
def: "A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins." [PMID:12039028]
synonym: "JAK-STAT cascade" NARROW []
synonym: "JAK-STAT signal transduction" EXACT [GOC:signaling]
synonym: "receptor signaling pathway via JAK-STAT" EXACT []
xref: Wikipedia:JAK-STAT_signaling_pathway
is_a: GO:0097696 ! cell surface receptor signaling pathway via STAT

[Term]
id: GO:0007260
name: tyrosine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:0042502
alt_id: GO:0042503
alt_id: GO:0042504
alt_id: GO:0042505
alt_id: GO:0042506
alt_id: GO:0042507
alt_id: GO:0042508
def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]
subset: gocheck_obsoletion_candidate
synonym: "tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "tyrosine phosphorylation of Stat7 protein" NARROW []
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
relationship: part_of GO:0007259 ! cell surface receptor signaling pathway via JAK-STAT

[Term]
id: GO:0007261
name: obsolete JAK-induced STAT protein dimerization
namespace: biological_process
def: "OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028]
comment: This term was made obsolete because it is ambiguous, and protein dimerization is represented by molecular function terms.
synonym: "JAK-induced STAT protein dimerization" EXACT []
is_obsolete: true
consider: GO:0007260
consider: GO:0046983

[Term]
id: GO:0007263
name: nitric oxide mediated signal transduction
namespace: biological_process
def: "An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190]
synonym: "nitric oxide signaling" EXACT [GOC:bf]
synonym: "nitric oxide-mediated signal transduction" EXACT []
synonym: "NO mediated signal transduction" EXACT []
synonym: "NO-mediated signal transduction" EXACT []
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0007264
name: small GTPase-mediated signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]
synonym: "Ras family protein signal transduction" NARROW []
synonym: "small GTPase mediated signal transduction" EXACT []
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0007265
name: Ras protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]
synonym: "Ras mediated signal transduction" EXACT []
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0007266
name: Rho protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]
synonym: "Rho mediated signal transduction" EXACT []
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0007267
name: cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]
subset: goslim_chembl
subset: goslim_plant
synonym: "cell-cell signalling" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023052 ! signaling

[Term]
id: GO:0007268
name: chemical synaptic transmission
namespace: biological_process
def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]
subset: goslim_synapse
synonym: "neurotransmission" RELATED [GOC:dph]
synonym: "signal transmission across a synapse" BROAD []
synonym: "synaptic transmission" BROAD []
xref: Wikipedia:Neurotransmission
is_a: GO:0098916 ! anterograde trans-synaptic signaling

[Term]
id: GO:0007269
name: neurotransmitter secretion
namespace: biological_process
alt_id: GO:0010554
def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph]
comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099643 ! signal release from synapse
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0007270
name: neuron-neuron synaptic transmission
namespace: biological_process
def: "The process of synaptic transmission from a neuron to another neuron across a synapse." [GOC:add, GOC:dos, GOC:jl, MeSH:D009435]
synonym: "nerve-nerve synaptic transmission" RELATED []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0007271
name: synaptic transmission, cholinergic
namespace: biological_process
def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic]
synonym: "cholinergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0007272
name: ensheathment of neurons
namespace: biological_process
def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "ionic insulation of neurons by glial cells" RELATED []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007273
name: obsolete regulation of synapse
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string made no sense.
synonym: "regulation of synapse" EXACT []
is_obsolete: true
consider: GO:0007268

[Term]
id: GO:0007274
name: neuromuscular synaptic transmission
namespace: biological_process
def: "The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0007275
name: multicellular organism development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
comment: Note that this term was 'developmental process'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0007276
name: gamete generation
namespace: biological_process
alt_id: GO:0009552
def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]
synonym: "gametogenesis" RELATED []
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0007277
name: pole cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048468 ! cell development
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0007278
name: pole cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007277 ! pole cell development

[Term]
id: GO:0007279
name: pole cell formation
namespace: biological_process
def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
comment: See also the Cell Ontology term 'pole cell ; CL:0000301'.
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007349 ! cellularization
relationship: part_of GO:0007277 ! pole cell development

[Term]
id: GO:0007280
name: obsolete pole cell migration
namespace: biological_process
def: "OBSOLETE. The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
comment: The reason for obsoletion is that the term is unnecessarily taxon-specific.
is_obsolete: true
replaced_by: GO:0008354

[Term]
id: GO:0007281
name: germ cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
synonym: "gametogenesis" NARROW []
synonym: "germ-cell development" EXACT []
synonym: "primordial germ cell development" NARROW []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048468 ! cell development
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0007282
name: cystoblast division
namespace: biological_process
def: "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446]
synonym: "cystoblast cell division" EXACT []
is_a: GO:0008356 ! asymmetric cell division
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0007283
name: spermatogenesis
namespace: biological_process
def: "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
synonym: "generation of spermatozoa" EXACT systematic_synonym []
xref: Wikipedia:Spermatogenesis
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048232 ! male gamete generation

[Term]
id: GO:0007284
name: spermatogonial cell division
namespace: biological_process
def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238]
comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'.
synonym: "spermatogonium division" EXACT []
is_a: GO:0051301 ! cell division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0007285
name: primary spermatocyte growth
namespace: biological_process
def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0007286
name: spermatid development
namespace: biological_process
def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
synonym: "spermatid cell development" EXACT []
synonym: "spermiogenesis" EXACT []
xref: Wikipedia:Spermiogenesis
is_a: GO:0007281 ! germ cell development
relationship: part_of GO:0048515 ! spermatid differentiation

[Term]
id: GO:0007287
name: Nebenkern assembly
namespace: biological_process
def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238, PMID:9550716]
comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'.
synonym: "Nebenkern formation" RELATED [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007288
name: sperm axoneme assembly
namespace: biological_process
def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035082 ! axoneme assembly
relationship: part_of GO:0120316 ! sperm flagellum assembly

[Term]
id: GO:0007289
name: spermatid nucleus differentiation
namespace: biological_process
def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
comment: See also the Cell Ontology term 'spermatid ; CL:0000018'.
synonym: "spermatid nuclear differentiation" EXACT []
is_a: GO:0006997 ! nucleus organization
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007290
name: spermatid nucleus elongation
namespace: biological_process
def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "spermatid nuclear elongation" EXACT []
is_a: GO:0006997 ! nucleus organization
relationship: part_of GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0007291
name: sperm individualization
namespace: biological_process
def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007349 ! cellularization
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007292
name: female gamete generation
namespace: biological_process
def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0007293
name: germarium-derived egg chamber formation
namespace: biological_process
def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007294
name: germarium-derived oocyte fate determination
namespace: biological_process
alt_id: GO:0016350
def: "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maintenance of oocyte identity" RELATED []
synonym: "oocyte cell fate determination" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030716 ! oocyte fate determination
relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation

[Term]
id: GO:0007295
name: growth of a germarium-derived egg chamber
namespace: biological_process
def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "egg chamber growth" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007296
name: vitellogenesis
namespace: biological_process
def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238]
synonym: "yolk formation" EXACT []
synonym: "yolk production" EXACT systematic_synonym []
xref: Wikipedia:Vitellogenesis
is_a: GO:0007028 ! cytoplasm organization
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0007297
name: follicle cell of egg chamber migration
namespace: biological_process
def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
synonym: "follicle cell migration" BROAD []
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0007298
name: border follicle cell migration
namespace: biological_process
def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
synonym: "border cell migration" BROAD []
is_a: GO:0007297 ! follicle cell of egg chamber migration

[Term]
id: GO:0007299
name: follicle cell of egg chamber-cell adhesion
namespace: biological_process
def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496]
synonym: "follicle cell adhesion" BROAD []
synonym: "ovarian follicle cell adhesion" EXACT []
is_a: GO:0090136 ! epithelial cell-cell adhesion
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0007300
name: ovarian nurse cell to oocyte transport
namespace: biological_process
def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "nurse cell to oocyte transport" BROAD []
is_a: GO:0006810 ! transport
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007301
name: female germline ring canal formation
namespace: biological_process
def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
synonym: "nurse cell ring canal formation" NARROW []
synonym: "ovarian ring canal formation" NARROW []
is_a: GO:0030725 ! germline ring canal formation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0007302
name: nurse cell nucleus anchoring
namespace: biological_process
def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238]
is_a: GO:0051647 ! nucleus localization

[Term]
id: GO:0007303
name: obsolete cytoplasmic transport, nurse cell to oocyte
namespace: biological_process
def: "OBSOLETE. The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0007304
name: chorion-containing eggshell formation
namespace: biological_process
def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "eggshell formation" BROAD []
is_a: GO:0030703 ! eggshell formation
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0007305
name: vitelline membrane formation involved in chorion-containing eggshell formation
namespace: biological_process
def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "vitelline membrane formation in chorion-containing eggshell" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030704 ! vitelline membrane formation
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0007306
name: egg chorion assembly
namespace: biological_process
def: "Construction of the chorion portion of the egg, which is a protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238, PMID:24804966]
synonym: "eggshell chorion formation" RELATED [GOC:dph, GOC:tb]
synonym: "insect chorion formation" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0007307
name: eggshell chorion gene amplification
namespace: biological_process
def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
is_a: GO:0006277 ! DNA amplification
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007306 ! egg chorion assembly

[Term]
id: GO:0007308
name: oocyte construction
namespace: biological_process
alt_id: GO:0048110
def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732]
synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0007309
name: oocyte axis specification
namespace: biological_process
alt_id: GO:0048111
def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte axis determination" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0007310
name: oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0008072
alt_id: GO:0048123
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0007309 ! oocyte axis specification
is_a: GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0007311
name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded
namespace: biological_process
alt_id: GO:0048124
def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb]
synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah]
synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah]
is_a: GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0007312
name: oocyte nucleus migration involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0008102
alt_id: GO:0030722
alt_id: GO:0048126
alt_id: GO:0048128
def: "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" BROAD []
synonym: "establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" RELATED [GOC:mah]
synonym: "establishment of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" RELATED [GOC:mah]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification" RELATED []
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification" RELATED [GOC:mah]
synonym: "nucleus positioning in oocyte during oocyte axis determination" BROAD []
synonym: "oocyte axis determination, establishment of localization of nucleus" BROAD []
synonym: "oocyte axis determination, establishment of oocyte nucleus localization" BROAD []
synonym: "oocyte axis determination, establishment of position of nucleus" BROAD []
synonym: "oocyte axis determination, oocyte nuclear migration" EXACT []
synonym: "oocyte axis determination, oocyte nucleus migration" EXACT []
synonym: "oocyte axis determination, positioning of nucleus" BROAD []
synonym: "oocyte nuclear migration during oocyte axis determination" EXACT []
synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "oocyte nucleus migration during oocyte axis specification" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte nucleus positioning during oocyte axis determination" BROAD []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0007313
name: maternal specification of dorsal/ventral axis, oocyte, soma encoded
namespace: biological_process
alt_id: GO:0048125
def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb]
synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah]
synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah]
is_a: GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0007314
name: oocyte anterior/posterior axis specification
namespace: biological_process
alt_id: GO:0048112
def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007309 ! oocyte axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo

[Term]
id: GO:0007315
name: pole plasm assembly
namespace: biological_process
alt_id: GO:0048113
def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
is_a: GO:0007028 ! cytoplasm organization
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification

[Term]
id: GO:0007316
name: pole plasm RNA localization
namespace: biological_process
alt_id: GO:0048116
def: "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of pole plasm RNA localization" EXACT []
synonym: "oocyte pole plasm RNA localization" EXACT []
synonym: "pole plasm RNA localisation" EXACT [GOC:mah]
is_a: GO:0006403 ! RNA localization
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0007317
name: regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah]
is_a: GO:1904580 ! regulation of intracellular mRNA localization
relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0007318
name: pole plasm protein localization
namespace: biological_process
alt_id: GO:0048115
def: "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of pole plasm protein localization" EXACT []
synonym: "oocyte pole plasm protein localization" EXACT []
synonym: "pole plasm protein localisation" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0007319
name: negative regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
synonym: "down regulation of oskar mRNA translation" EXACT []
synonym: "down-regulation of oskar mRNA translation" EXACT []
synonym: "downregulation of oskar mRNA translation" EXACT []
synonym: "inhibition of oskar mRNA translation" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0046011 ! regulation of oskar mRNA translation

[Term]
id: GO:0007320
name: insemination
namespace: biological_process
def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089]
xref: Wikipedia:Insemination
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007620 ! copulation

[Term]
id: GO:0007321
name: sperm displacement
namespace: biological_process
def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373]
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0007323
name: peptide pheromone maturation
namespace: biological_process
alt_id: GO:0007324
alt_id: GO:0007326
alt_id: GO:0046613
def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
synonym: "pheromone processing" EXACT []
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0007329
name: obsolete positive regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT []
synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
is_obsolete: true

[Term]
id: GO:0007336
name: obsolete bilateral process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it gives no indication of what it refers to.
synonym: "bilateral process" EXACT []
is_obsolete: true

[Term]
id: GO:0007337
name: obsolete unilateral process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it gives no indication of what it refers to.
synonym: "unilateral process" EXACT []
is_obsolete: true

[Term]
id: GO:0007338
name: single fertilization
namespace: biological_process
def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]
synonym: "zygote biosynthesis" RELATED []
synonym: "zygote formation" RELATED []
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0007339
name: binding of sperm to zona pellucida
namespace: biological_process
def: "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437]
synonym: "ZPG binding" RELATED []
is_a: GO:0035036 ! sperm-egg recognition

[Term]
id: GO:0007340
name: acrosome reaction
namespace: biological_process
def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida." [GOC:dph, PMID:11175768, PMID:21042299, PMID:3886029]
comment: If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
xref: Wikipedia:Acrosome_reaction
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007341
name: penetration of zona pellucida
namespace: biological_process
def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, PMID:21755679]
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007342
name: fusion of sperm to egg plasma membrane involved in single fertilization
namespace: biological_process
def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:dph, GOC:jl, PMID:17644969]
synonym: "sperm-oocyte fusion" NARROW []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007343
name: egg activation
namespace: biological_process
def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751]
xref: Wikipedia:Egg_activation
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007344
name: pronuclear fusion
namespace: biological_process
def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
is_a: GO:0000741 ! karyogamy
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007345
name: obsolete embryogenesis and morphogenesis
namespace: biological_process
def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888]
comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis.
synonym: "embryogenesis and morphogenesis" EXACT []
is_obsolete: true
consider: GO:0009653
consider: GO:0009790

[Term]
id: GO:0007346
name: regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "mitotic cell cycle modulation" EXACT []
synonym: "mitotic cell cycle regulation" EXACT []
synonym: "mitotic cell cycle regulator" RELATED []
synonym: "modulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
relationship: regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007347
name: regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "preblastoderm mitotic cell cycle modulation" EXACT []
synonym: "preblastoderm mitotic cell cycle regulation" EXACT []
synonym: "preblastoderm mitotic cell cycle regulator" RELATED []
synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0007348
name: regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of syncytial blastoderm cell cycle" EXACT []
synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "syncytial blastoderm cell cycle modulation" EXACT []
synonym: "syncytial blastoderm cell cycle regulation" EXACT []
synonym: "syncytial blastoderm cell cycle regulator" RELATED []
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0022402 ! cell cycle process
relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0007349
name: cellularization
namespace: biological_process
alt_id: GO:0009796
def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007350
name: blastoderm segmentation
namespace: biological_process
def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
is_a: GO:0035282 ! segmentation

[Term]
id: GO:0007351
name: tripartite regional subdivision
namespace: biological_process
def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0007352
name: zygotic specification of dorsal/ventral axis
namespace: biological_process
def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf]
synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah]
synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph]
synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0007353
name: obsolete ventral/lateral system
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "ventral/lateral system" EXACT []
is_obsolete: true
consider: GO:0009880

[Term]
id: GO:0007354
name: zygotic determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo

[Term]
id: GO:0007355
name: anterior region determination
namespace: biological_process
def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007356
name: thorax and anterior abdomen determination
namespace: biological_process
def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007357
name: obsolete positive regulation of central gap gene transcription
namespace: biological_process
def: "OBSOLETE. The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [ISBN:0879694238]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of central gap gene" BROAD []
synonym: "activation of central gap gene transcription" NARROW []
synonym: "stimulation of central gap gene transcription" NARROW []
synonym: "up regulation of central gap gene transcription" EXACT []
synonym: "up-regulation of central gap gene transcription" EXACT []
synonym: "upregulation of central gap gene transcription" EXACT []
is_obsolete: true

[Term]
id: GO:0007358
name: obsolete establishment of central gap gene boundaries
namespace: biological_process
def: "OBSOLETE. Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
comment: This term has been obsoleted because it represents a transcriptional feedback loop covered by other processes.
is_obsolete: true

[Term]
id: GO:0007359
name: posterior abdomen determination
namespace: biological_process
def: "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
comment: Note that this process is exemplified in insects by the actions of the knirps gene product.
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007360
name: obsolete positive regulation of posterior gap gene transcription
namespace: biological_process
def: "OBSOLETE. The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [ISBN:0879694238]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of posterior gap gene" BROAD []
synonym: "activation of posterior gap gene transcription" NARROW []
synonym: "knirps activation" NARROW []
synonym: "stimulation of posterior gap gene transcription" NARROW []
synonym: "up regulation of posterior gap gene transcription" EXACT []
synonym: "up-regulation of posterior gap gene transcription" EXACT []
synonym: "upregulation of posterior gap gene transcription" EXACT []
is_obsolete: true

[Term]
id: GO:0007361
name: obsolete establishment of posterior gap gene boundaries
namespace: biological_process
def: "OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
comment: This term has been obsoleted because it represents a transcriptional feedback loop covered by other processes.
is_obsolete: true

[Term]
id: GO:0007362
name: terminal region determination
namespace: biological_process
def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007363
name: obsolete positive regulation of terminal gap gene transcription
namespace: biological_process
def: "OBSOLETE. The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [ISBN:0879694238]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of terminal gap gene" BROAD []
synonym: "activation of terminal gap gene transcription" NARROW []
synonym: "stimulation of terminal gap gene transcription" NARROW []
synonym: "up regulation of terminal gap gene transcription" EXACT []
synonym: "up-regulation of terminal gap gene transcription" EXACT []
synonym: "upregulation of terminal gap gene transcription" EXACT []
is_obsolete: true

[Term]
id: GO:0007364
name: obsolete establishment of terminal gap gene boundary
namespace: biological_process
def: "OBSOLETE. Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
comment: This term has been obsoleted because it represents a transcriptional feedback loop covered by other processes.
is_obsolete: true

[Term]
id: GO:0007365
name: periodic partitioning
namespace: biological_process
def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma]
comment: Note that examples of periodic partitions are tagmata, segments or parasegments.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0007366
name: periodic partitioning by pair rule gene
namespace: biological_process
def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
is_a: GO:0007365 ! periodic partitioning
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0007367
name: segment polarity determination
namespace: biological_process
def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
is_a: GO:0007365 ! periodic partitioning

[Term]
id: GO:0007368
name: determination of left/right symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]
synonym: "determination of left/right asymmetry" EXACT [GOC:dph]
is_a: GO:0009855 ! determination of bilateral symmetry
relationship: part_of GO:0060972 ! left/right pattern formation

[Term]
id: GO:0007369
name: gastrulation
namespace: biological_process
def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
subset: goslim_drosophila
xref: Wikipedia:Gastrulation
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0007370
name: ventral furrow formation
namespace: biological_process
def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:0879694238]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007371
name: ventral midline determination
namespace: biological_process
alt_id: GO:0007372
alt_id: GO:0007373
def: "The regionalization process in which the area where the ventral midline will form is specified." [GOC:bf, GOC:isa_complete, GOC:vk]
synonym: "determination of anterior border of ventral midline" NARROW []
synonym: "determination of posterior border of ventral midline" NARROW []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007418 ! ventral midline development

[Term]
id: GO:0007374
name: posterior midgut invagination
namespace: biological_process
def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:0879694238]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007375
name: anterior midgut invagination
namespace: biological_process
def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:0879694238]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007376
name: cephalic furrow formation
namespace: biological_process
def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:0879694238]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007377
name: germ-band extension
namespace: biological_process
def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:0879694238]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007378
name: amnioserosa formation
namespace: biological_process
def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:0879694238]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007379
name: segment specification
namespace: biological_process
def: "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0035282 ! segmentation

[Term]
id: GO:0007380
name: specification of segmental identity, head
namespace: biological_process
def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0035287 ! head segmentation

[Term]
id: GO:0007381
name: specification of segmental identity, labial segment
namespace: biological_process
def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0007382
name: specification of segmental identity, maxillary segment
namespace: biological_process
def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0007383
name: specification of segmental identity, antennal segment
namespace: biological_process
def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035288 ! anterior head segmentation

[Term]
id: GO:0007384
name: specification of segmental identity, thorax
namespace: biological_process
def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0035292 ! specification of segmental identity, trunk

[Term]
id: GO:0007385
name: specification of segmental identity, abdomen
namespace: biological_process
def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0035292 ! specification of segmental identity, trunk

[Term]
id: GO:0007386
name: compartment pattern specification
namespace: biological_process
def: "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "compartment specification" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0007387
name: anterior compartment pattern formation
namespace: biological_process
def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "anterior compartment pattern specification" RELATED [GOC:dph]
is_a: GO:0007386 ! compartment pattern specification

[Term]
id: GO:0007388
name: posterior compartment specification
namespace: biological_process
def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0007386 ! compartment pattern specification

[Term]
id: GO:0007389
name: pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
subset: goslim_drosophila
synonym: "pattern biosynthesis" RELATED []
synonym: "pattern formation" RELATED []
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007390
name: germ-band shortening
namespace: biological_process
def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
synonym: "germ-band retraction" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0007391
name: dorsal closure
namespace: biological_process
def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0007392
name: initiation of dorsal closure
namespace: biological_process
def: "Events that occur at the start of dorsal closure." [GOC:bf]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007393
name: dorsal closure, leading edge cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138]
is_a: GO:0035028 ! leading edge cell fate determination
relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment

[Term]
id: GO:0007394
name: dorsal closure, elongation of leading edge cells
namespace: biological_process
def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0016476 ! regulation of embryonic cell shape
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007392 ! initiation of dorsal closure

[Term]
id: GO:0007395
name: dorsal closure, spreading of leading edge cells
namespace: biological_process
def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007396
name: suture of dorsal opening
namespace: biological_process
def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007397
name: obsolete histogenesis and organogenesis
namespace: biological_process
def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "histogenesis and organogenesis" EXACT []
is_obsolete: true
consider: GO:0009887
consider: GO:0009888

[Term]
id: GO:0007398
name: ectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007399
name: nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
subset: goslim_drosophila
synonym: "pan-neural process" RELATED []
is_a: GO:0048731 ! system development

[Term]
id: GO:0007400
name: neuroblast fate determination
namespace: biological_process
alt_id: GO:0007408
alt_id: GO:0043347
alt_id: GO:0043348
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
synonym: "neuroblast cell fate determination" EXACT []
synonym: "neuroblast identity determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0014017 ! neuroblast fate commitment

[Term]
id: GO:0007401
name: obsolete pan-neural process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because its meaning is ambiguous.
synonym: "pan-neural process" EXACT []
is_obsolete: true
consider: GO:0007399
consider: GO:0050877

[Term]
id: GO:0007402
name: ganglion mother cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0001709 ! cell fate determination

[Term]
id: GO:0007403
name: glial cell fate determination
namespace: biological_process
alt_id: GO:0043361
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0021781 ! glial cell fate commitment

[Term]
id: GO:0007405
name: neuroblast proliferation
namespace: biological_process
alt_id: GO:0043349
alt_id: GO:0043350
def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007406
name: negative regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai]
synonym: "down regulation of neuroblast proliferation" EXACT []
synonym: "down-regulation of neuroblast proliferation" EXACT []
synonym: "downregulation of neuroblast proliferation" EXACT []
synonym: "inhibition of neuroblast proliferation" NARROW []
synonym: "suppression of neuroblast proliferation" EXACT []
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
relationship: negatively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0007407
name: neuroblast activation
namespace: biological_process
alt_id: GO:0043351
alt_id: GO:0043352
def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007409
name: axonogenesis
namespace: biological_process
alt_id: GO:0007410
def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon).
synonym: "axon growth" NARROW []
synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308]
synonym: "neuron long process generation" EXACT systematic_synonym []
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0061564 ! axon development

[Term]
id: GO:0007411
name: axon guidance
namespace: biological_process
alt_id: GO:0008040
def: "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
synonym: "axon chemotaxis" RELATED []
synonym: "axon growth cone guidance" NARROW []
synonym: "axon pathfinding" EXACT [GOC:mah]
xref: Wikipedia:Axon_guidance
is_a: GO:0097485 ! neuron projection guidance
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007412
name: axon target recognition
namespace: biological_process
def: "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007413
name: axonal fasciculation
namespace: biological_process
def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
synonym: "fasciculation of neuron" RELATED []
is_a: GO:0008038 ! neuron recognition
is_a: GO:0106030 ! neuron projection fasciculation
relationship: part_of GO:0061564 ! axon development

[Term]
id: GO:0007414
name: axonal defasciculation
namespace: biological_process
def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X]
synonym: "defasciculation of neuron" RELATED []
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0061564 ! axon development

[Term]
id: GO:0007415
name: defasciculation of motor neuron axon
namespace: biological_process
def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
is_a: GO:0007414 ! axonal defasciculation

[Term]
id: GO:0007416
name: synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah]
subset: goslim_synapse
synonym: "synapse biogenesis" EXACT [GOC:mah]
synonym: "synaptogenesis" EXACT [GOC:mah]
xref: Wikipedia:Synaptogenesis
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007417
name: central nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
synonym: "CNS development" EXACT []
xref: Wikipedia:Neural_development
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007418
name: ventral midline development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0007419
name: ventral cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, PMID:30826502]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0007420
name: brain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0007421
name: stomatogastric nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007422
name: peripheral nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007423
name: sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
subset: goslim_drosophila
synonym: "sense organ development" EXACT [GOC:dph]
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0007424
name: open tracheal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'.
is_a: GO:0060541 ! respiratory system development

[Term]
id: GO:0007425
name: epithelial cell fate determination, open tracheal system
namespace: biological_process
alt_id: GO:0046846
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
synonym: "tracheal cell fate determination" BROAD []
synonym: "tracheal epithelial cell fate determination" EXACT []
synonym: "tracheal placode cell fate determination" RELATED []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007426
name: tracheal outgrowth, open tracheal system
namespace: biological_process
def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007427
name: epithelial cell migration, open tracheal system
namespace: biological_process
def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "tracheal cell migration" BROAD []
synonym: "tracheal epithelial cell migration" RELATED []
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007428
name: primary branching, open tracheal system
namespace: biological_process
def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:29844090]
synonym: "primary tracheal branching" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007429
name: secondary branching, open tracheal system
namespace: biological_process
def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:29844090]
synonym: "secondary tracheal branching" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007430
name: terminal branching, open tracheal system
namespace: biological_process
def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:29844090]
synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007431
name: salivary gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
subset: goslim_drosophila
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035272 ! exocrine system development

[Term]
id: GO:0007432
name: salivary gland boundary specification
namespace: biological_process
def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
synonym: "salivary gland determination" EXACT []
is_a: GO:0010160 ! formation of animal organ boundary
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0007433
name: larval salivary gland boundary specification
namespace: biological_process
def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957]
synonym: "larval salivary gland determination" BROAD [GOC:tb]
is_a: GO:0007432 ! salivary gland boundary specification
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007434
name: adult salivary gland boundary specification
namespace: biological_process
def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957]
synonym: "larval salivary gland determination" BROAD [GOC:tb]
is_a: GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0007435
name: salivary gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0007436
name: larval salivary gland morphogenesis
namespace: biological_process
def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
is_a: GO:0007435 ! salivary gland morphogenesis
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007437
name: adult salivary gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the adult salivary gland are generated and organized." [GOC:go_curators]
is_a: GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0007438
name: oenocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0001742 ! oenocyte differentiation

[Term]
id: GO:0007439
name: ectodermal digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators]
synonym: "ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0007440
name: foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0007441
name: anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized." [GOC:go_curators]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis

[Term]
id: GO:0007442
name: hindgut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: part_of GO:0061525 ! hindgut development

[Term]
id: GO:0007443
name: Malpighian tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'.
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0061333 ! renal tubule morphogenesis
relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis
relationship: part_of GO:0072002 ! Malpighian tubule development

[Term]
id: GO:0007444
name: imaginal disc development
namespace: biological_process
def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0007445
name: determination of imaginal disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007446
name: imaginal disc growth
namespace: biological_process
def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007447
name: imaginal disc pattern formation
namespace: biological_process
def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007448
name: anterior/posterior pattern specification, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0007449
name: proximal/distal pattern formation, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0007450
name: dorsal/ventral pattern formation, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah]
synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0007451
name: dorsal/ventral lineage restriction, imaginal disc
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah]
synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah]
is_a: GO:0035161 ! imaginal disc lineage restriction
relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc

[Term]
id: GO:0007453
name: clypeo-labral disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238]
synonym: "clypeo-labral disc metamorphosis" EXACT []
synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0007454
name: labial disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
synonym: "labial disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035217 ! labial disc development

[Term]
id: GO:0007455
name: eye-antennal disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
synonym: "eye-antennal disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0007458
name: progression of morphogenetic furrow involved in compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883]
synonym: "progression of morphogenetic furrow during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0007460
name: R8 cell fate commitment
namespace: biological_process
alt_id: GO:0007461
def: "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883]
synonym: "restriction of R8 fate" EXACT []
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0007462
name: R1/R6 cell fate commitment
namespace: biological_process
def: "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0048052 ! R1/R6 cell differentiation

[Term]
id: GO:0007463
name: R2/R5 cell fate commitment
namespace: biological_process
def: "The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0048054 ! R2/R5 cell differentiation

[Term]
id: GO:0007464
name: R3/R4 cell fate commitment
namespace: biological_process
def: "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity
relationship: part_of GO:0048056 ! R3/R4 cell differentiation

[Term]
id: GO:0007465
name: R7 cell fate commitment
namespace: biological_process
def: "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0007468
name: obsolete regulation of rhodopsin gene expression
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb]
comment: This term was obsoleted because it refers to a specific gene product. The gene product should be captured as an annotation extension using 'has input'.
synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0007469
name: antennal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0007470
name: prothoracic disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238]
synonym: "prothoracic disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035219 ! prothoracic disc development

[Term]
id: GO:0007471
name: obsolete prothoracic morphogenesis
namespace: biological_process
def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized." [GOC:jid]
comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process.
synonym: "prothoracic morphogenesis" EXACT []
is_obsolete: true
consider: GO:0007470

[Term]
id: GO:0007472
name: wing disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
synonym: "wing disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0007473
name: wing disc proximal/distal pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf]
is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0007474
name: imaginal disc-derived wing vein specification
namespace: biological_process
def: "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
synonym: "wing vein specification" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0007475
name: apposition of dorsal and ventral imaginal disc-derived wing surfaces
namespace: biological_process
def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
synonym: "apposition of dorsal and ventral wing surfaces" EXACT []
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis

[Term]
id: GO:0007476
name: imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
synonym: "wing morphogenesis" EXACT []
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
relationship: part_of GO:0007472 ! wing disc morphogenesis

[Term]
id: GO:0007477
name: notum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0007478
name: leg disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
synonym: "leg disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035218 ! leg disc development

[Term]
id: GO:0007479
name: leg disc proximal/distal pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc
is_a: GO:0035223 ! leg disc pattern formation

[Term]
id: GO:0007480
name: imaginal disc-derived leg morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
relationship: part_of GO:0007478 ! leg disc morphogenesis

[Term]
id: GO:0007481
name: haltere disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238]
synonym: "haltere disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035216 ! haltere disc development

[Term]
id: GO:0007482
name: haltere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, PMID:32659004]
is_a: GO:0048737 ! imaginal disc-derived appendage development
relationship: part_of GO:0035216 ! haltere disc development

[Term]
id: GO:0007483
name: genital disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
synonym: "genital disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007484
name: imaginal disc-derived genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "genital development" BROAD []
is_a: GO:0048806 ! genitalia development
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007485
name: imaginal disc-derived male genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "male genital development" BROAD []
is_a: GO:0007484 ! imaginal disc-derived genitalia development

[Term]
id: GO:0007486
name: imaginal disc-derived female genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "female genital development" BROAD []
is_a: GO:0007484 ! imaginal disc-derived genitalia development
is_a: GO:0030540 ! female genitalia development

[Term]
id: GO:0007487
name: analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007488
name: histoblast morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238]
synonym: "histoblast metamorphosis" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0007489
name: maintenance of imaginal histoblast diploidy
namespace: biological_process
def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007490
name: tergite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, PMID:16451739]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007491
name: sternite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jid, PMID:16451739]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007492
name: endoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007493
name: endodermal cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'.
synonym: "endoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001711 ! endodermal cell fate commitment

[Term]
id: GO:0007494
name: midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
is_a: GO:0048565 ! digestive tract development

[Term]
id: GO:0007495
name: visceral mesoderm-endoderm interaction involved in midgut development
namespace: biological_process
def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete]
synonym: "visceral mesoderm/endoderm interaction" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007496
name: anterior midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007497
name: posterior midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007498
name: mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
subset: goslim_drosophila
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007499
name: ectoderm and mesoderm interaction
namespace: biological_process
def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete]
synonym: "ectoderm/mesoderm interaction" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0007500
name: mesodermal cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'.
synonym: "mesoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001710 ! mesodermal cell fate commitment

[Term]
id: GO:0007501
name: mesodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'.
synonym: "mesoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001710 ! mesodermal cell fate commitment

[Term]
id: GO:0007502
name: digestive tract mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0007498 ! mesoderm development
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0007503
name: fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089]
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0007504
name: larval fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238]
is_a: GO:0007503 ! fat body development
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007505
name: adult fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238]
is_a: GO:0007503 ! fat body development

[Term]
id: GO:0007506
name: gonadal mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0008406 ! gonad development

[Term]
id: GO:0007507
name: heart development
namespace: biological_process
alt_id: GO:0007511
def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
synonym: "cardiac development" RELATED []
synonym: "dorsal vessel development" NARROW []
xref: Wikipedia:Heart_development
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072359 ! circulatory system development

[Term]
id: GO:0007508
name: larval heart development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:0879694238]
is_a: GO:0007507 ! heart development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007509
name: mesoderm migration involved in gastrulation
namespace: biological_process
def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat]
is_a: GO:0008078 ! mesodermal cell migration
is_a: GO:0042074 ! cell migration involved in gastrulation
is_a: GO:0090130 ! tissue migration
relationship: part_of GO:0001707 ! mesoderm formation

[Term]
id: GO:0007510
name: cardioblast cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060913 ! cardiac cell fate determination
relationship: part_of GO:0042684 ! cardioblast cell fate commitment

[Term]
id: GO:0007512
name: adult heart development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf]
synonym: "adult cardiac development" RELATED []
is_a: GO:0007507 ! heart development

[Term]
id: GO:0007515
name: obsolete lymph gland development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jid]
comment: This term was made obsolete because it was wrongly defined.
synonym: "lymph gland development" EXACT []
is_obsolete: true
consider: GO:0048535
consider: GO:0048542

[Term]
id: GO:0007516
name: hemocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
synonym: "arthropod blood cell development" EXACT []
is_a: GO:0030097 ! hemopoiesis
relationship: part_of GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0007517
name: muscle organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
is_a: GO:0048513 ! animal organ development
is_a: GO:0061061 ! muscle structure development

[Term]
id: GO:0007518
name: myoblast fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0007519
name: skeletal muscle tissue development
namespace: biological_process
alt_id: GO:0048637
def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
synonym: "myogenesis" RELATED []
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0007520
name: myoblast fusion
namespace: biological_process
def: "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: part_of GO:0014902 ! myotube differentiation

[Term]
id: GO:0007521
name: muscle cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0042693 ! muscle cell fate commitment

[Term]
id: GO:0007522
name: visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development

[Term]
id: GO:0007523
name: larval visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007522 ! visceral muscle development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007524
name: adult visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007522 ! visceral muscle development

[Term]
id: GO:0007525
name: somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
is_a: GO:0061061 ! muscle structure development

[Term]
id: GO:0007526
name: larval somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007525 ! somatic muscle development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007527
name: adult somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007525 ! somatic muscle development

[Term]
id: GO:0007528
name: neuromuscular junction development
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
synonym: "neuromuscular junction organization" EXACT []
synonym: "neuromuscular junction stability" RELATED [GOC:pr]
synonym: "NMJ stability" RELATED [GOC:pr]
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0007529
name: establishment of synaptic specificity at neuromuscular junction
namespace: biological_process
def: "The biological process in which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete]
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007528 ! neuromuscular junction development

[Term]
id: GO:0007530
name: sex determination
namespace: biological_process
def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
xref: Wikipedia:Sex-determination_system
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0007531
name: mating type determination
namespace: biological_process
def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [PMID:28916791, PMID:33313646, PMID:8274857, PMID:8785123]
is_a: GO:0007530 ! sex determination

[Term]
id: GO:0007532
name: regulation of mating-type specific transcription, DNA-templated
namespace: biological_process
def: "Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "mating-type specific transcriptional control" EXACT []
synonym: "regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH]
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:0007531 ! mating type determination

[Term]
id: GO:0007533
name: mating type switching
namespace: biological_process
def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492]
synonym: "mating type switching and recombination" RELATED []
is_a: GO:0007531 ! mating type determination
is_a: GO:0022413 ! reproductive process in single-celled organism

[Term]
id: GO:0007534
name: gene conversion at mating-type locus
namespace: biological_process
alt_id: GO:0000728
alt_id: GO:0000734
alt_id: GO:0010708
alt_id: GO:0031292
alt_id: GO:0034636
alt_id: GO:0061500
def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:10716938, PMID:7646483, PMID:9928492]
synonym: "gene conversion at mating-type locus, DNA double-strand break formation" NARROW []
synonym: "gene conversion at mating-type locus, DNA double-strand break processing" NARROW []
synonym: "gene conversion at mating-type locus, DNA repair synthesis" NARROW []
synonym: "gene conversion at mating-type locus, termination of copy-synthesis" NARROW []
synonym: "heteroduplex formation involved in gene conversion at mating-type locus" NARROW []
synonym: "strand invasion involved in gene conversion at mating-type locus" EXACT []
is_a: GO:0006312 ! mitotic recombination
is_a: GO:0035822 ! gene conversion
relationship: part_of GO:0007533 ! mating type switching

[Term]
id: GO:0007535
name: donor selection
namespace: biological_process
def: "The process that determines which donor locus a cell uses, in preference to another, in mating type switching." [GOC:mah, PMID:9928492]
synonym: "donor preference" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0007533 ! mating type switching

[Term]
id: GO:0007536
name: activation of recombination (HML)
namespace: biological_process
def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492]
is_a: GO:0007535 ! donor selection
is_a: GO:0045911 ! positive regulation of DNA recombination

[Term]
id: GO:0007537
name: inactivation of recombination (HML)
namespace: biological_process
def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492]
is_a: GO:0007535 ! donor selection
is_a: GO:0045910 ! negative regulation of DNA recombination

[Term]
id: GO:0007538
name: primary sex determination
namespace: biological_process
def: "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007539
name: primary sex determination, soma
namespace: biological_process
def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems]
is_a: GO:0007538 ! primary sex determination
relationship: part_of GO:0018993 ! somatic sex determination

[Term]
id: GO:0007540
name: sex determination, establishment of X:A ratio
namespace: biological_process
def: "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete, GOC:mr, PMID:20622855, Wikipedia:XY_sex-determination_system]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007539 ! primary sex determination, soma

[Term]
id: GO:0007541
name: sex determination, primary response to X:A ratio
namespace: biological_process
def: "The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007539 ! primary sex determination, soma

[Term]
id: GO:0007542
name: primary sex determination, germ-line
namespace: biological_process
def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems]
is_a: GO:0007538 ! primary sex determination
relationship: part_of GO:0018992 ! germ-line sex determination

[Term]
id: GO:0007543
name: sex determination, somatic-gonadal interaction
namespace: biological_process
def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete]
synonym: "sex determination, somatic/gonadal interaction" EXACT []
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0007542 ! primary sex determination, germ-line

[Term]
id: GO:0007545
name: processes downstream of sex determination signal
namespace: biological_process
def: "The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways." [GOC:mah]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007546
name: somatic processes downstream of sex determination signal
namespace: biological_process
def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems]
is_a: GO:0007545 ! processes downstream of sex determination signal

[Term]
id: GO:0007547
name: germ-line processes downstream of sex determination signal
namespace: biological_process
def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems]
is_a: GO:0007545 ! processes downstream of sex determination signal
relationship: part_of GO:0018992 ! germ-line sex determination

[Term]
id: GO:0007548
name: sex differentiation
namespace: biological_process
def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai]
xref: Wikipedia:Sexual_differentiation
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0007549
name: sex-chromosome dosage compensation
namespace: biological_process
def: "Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes." [GOC:ems, PMID:11498577, PMID:30049999, PMID:35306885]
synonym: "dosage compensation" BROAD []
synonym: "sex chromosome dosage compensation" EXACT []
xref: Wikipedia:Sex-chromosome_dosage_compensation
is_a: GO:0040029 ! epigenetic regulation of gene expression

[Term]
id: GO:0007550
name: obsolete establishment of dosage compensation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:isa_complete]
comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms.
synonym: "establishment of dosage compensation" EXACT []
is_obsolete: true
consider: GO:0007549

[Term]
id: GO:0007551
name: obsolete maintenance of dosage compensation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:isa_complete]
comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms.
synonym: "maintenance of dosage compensation" EXACT []
is_obsolete: true
consider: GO:0007549

[Term]
id: GO:0007552
name: metamorphosis
namespace: biological_process
alt_id: GO:0046698
alt_id: GO:0046699
def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
xref: Wikipedia:Metamorphosis
is_a: GO:0007275 ! multicellular organism development

[Term]
id: GO:0007553
name: regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
synonym: "regulation of ecdysteroid metabolism" EXACT []
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0007554
name: regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "regulation of ecdysteroid anabolism" EXACT []
synonym: "regulation of ecdysteroid biosynthesis" EXACT []
synonym: "regulation of ecdysteroid formation" EXACT []
synonym: "regulation of ecdysteroid synthesis" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0007555
name: regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell." [GOC:go_curators]
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0007556
name: regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone metabolism" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
relationship: part_of GO:0002165 ! instar larval or pupal development
relationship: regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0007557
name: regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone anabolism" EXACT []
synonym: "regulation of juvenile hormone biosynthesis" EXACT []
synonym: "regulation of juvenile hormone formation" EXACT []
synonym: "regulation of juvenile hormone synthesis" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0007558
name: regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0007559
name: obsolete histolysis
namespace: biological_process
def: "OBSOLETE. The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
xref: Wikipedia:Histolysis
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0007560
name: imaginal disc morphogenesis
namespace: biological_process
alt_id: GO:0007452
def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid]
synonym: "imaginal disc metamorphosis" EXACT []
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0007444 ! imaginal disc development
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0007561
name: imaginal disc eversion
namespace: biological_process
def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0007562
name: eclosion
namespace: biological_process
def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]
xref: Wikipedia:Pupa#Emergence
is_a: GO:0071684 ! organism emergence from protective structure
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007563
name: regulation of eclosion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0007562 ! eclosion

[Term]
id: GO:0007564
name: regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu]
synonym: "regulation of cuticle hardening" NARROW []
synonym: "regulation of cuticle tanning" EXACT []
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0007565
name: female pregnancy
namespace: biological_process
def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825]
subset: goslim_chembl
synonym: "carrying of young" RELATED []
synonym: "gestation" EXACT []
xref: Wikipedia:Gestation
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process

[Term]
id: GO:0007566
name: embryo implantation
namespace: biological_process
def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, PMID:10882512]
synonym: "blastocyst implantation" EXACT []
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0007567
name: parturition
namespace: biological_process
def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732]
synonym: "egg laying" NARROW []
synonym: "giving birth" EXACT []
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process

[Term]
id: GO:0007568
name: obsolete aging
namespace: biological_process
alt_id: GO:0016280
def: "OBSOLETE. A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
comment: The reason for obsoletion is that this represents a phenotype.
synonym: "ageing" EXACT []
is_obsolete: true

[Term]
id: GO:0007569
name: obsolete cell aging
namespace: biological_process
def: "OBSOLETE. An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469)." [GOC:PO_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "cell ageing" EXACT []
is_obsolete: true
consider: GO:0090398

[Term]
id: GO:0007570
name: obsolete age dependent accumulation of genetic damage
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age dependent accumulation of genetic damage" EXACT []
is_obsolete: true

[Term]
id: GO:0007571
name: obsolete age-dependent general metabolic decline
namespace: biological_process
def: "OBSOLETE. A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis." [GOC:jh, GOC:mah, PMID:9891807]
comment: This term was obsolete because it represents a phenotype.
synonym: "age-dependent decreased translational activity" NARROW []
synonym: "age-dependent increased protein content" NARROW []
synonym: "age-dependent yeast cell size increase" RELATED []
synonym: "nucleolar size increase" NARROW []
is_obsolete: true

[Term]
id: GO:0007572
name: obsolete age dependent decreased translational activity
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age dependent decreased translational activity" EXACT []
is_obsolete: true

[Term]
id: GO:0007573
name: obsolete age dependent increased protein content
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age dependent increased protein content" EXACT []
is_obsolete: true

[Term]
id: GO:0007574
name: obsolete cell aging (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators]
comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'.
synonym: "cell aging (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0007575
name: obsolete nucleolar size increase
namespace: biological_process
def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "nucleolar size increase" EXACT []
is_obsolete: true

[Term]
id: GO:0007576
name: obsolete nucleolar fragmentation
namespace: biological_process
alt_id: GO:0046616
def: "OBSOLETE. The cell aging process that results in the nucleolus breaking down into fragments." [GOC:mah, PMID:9271578]
comment: This term was obsoleted because it represents a readout.
synonym: "nucleolar size increase" RELATED []
is_obsolete: true

[Term]
id: GO:0007577
name: obsolete autophagic death (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators]
comment: This term was made obsolete because a more correct term has been created.
synonym: "autophagic death (sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0048102

[Term]
id: GO:0007578
name: obsolete aging dependent sterility (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators]
comment: This term was made obsolete because it reflected a trait or phenotype.
synonym: "aging dependent sterility (sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0030466

[Term]
id: GO:0007579
name: obsolete senescence factor accumulation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jh]
comment: This term was made obsolete because it does not represent a process.
synonym: "senescence factor accumulation" EXACT []
is_obsolete: true

[Term]
id: GO:0007580
name: obsolete extrachromosomal circular DNA accumulation involved in cell aging
namespace: biological_process
def: "OBSOLETE. Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807]
comment: This term was obsoleted because it represents a phenotype.
synonym: "extrachromosomal circular DNA accumulation during cell ageing" RELATED []
synonym: "extrachromosomal circular DNA accumulation during cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0043007

[Term]
id: GO:0007581
name: obsolete age-dependent yeast cell size increase
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:sgd_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age-dependent yeast cell size increase" EXACT []
is_obsolete: true

[Term]
id: GO:0007583
name: obsolete killer activity
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes.
synonym: "killer activity" EXACT []
is_obsolete: true
consider: GO:0042267

[Term]
id: GO:0007584
name: response to nutrient
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]
synonym: "nutritional response pathway" NARROW []
synonym: "response to nutrients" EXACT []
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0007585
name: respiratory gaseous exchange by respiratory system
namespace: biological_process
def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732]
subset: goslim_chembl
synonym: "breathing" BROAD []
synonym: "respiration" BROAD []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007586
name: digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
xref: Wikipedia:Digestion
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007588
name: excretion
namespace: biological_process
def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023]
subset: gocheck_do_not_annotate
subset: goslim_pir
xref: Wikipedia:Excretion
is_a: GO:0003008 ! system process

[Term]
id: GO:0007589
name: body fluid secretion
namespace: biological_process
def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0046903 ! secretion
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007590
name: obsolete fat body metabolic process (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body.
synonym: "fat body metabolic process (sensu Insecta)" EXACT []
is_obsolete: true

[Term]
id: GO:0007591
name: molting cycle, chitin-based cuticle
namespace: biological_process
def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
synonym: "chitin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0007592
name: obsolete protein-based cuticle development
namespace: biological_process
def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "protein-based cuticle anabolism" EXACT []
synonym: "protein-based cuticle biosynthetic process" EXACT []
synonym: "protein-based cuticle development" EXACT []
synonym: "protein-based cuticle formation" EXACT []
synonym: "protein-based cuticle synthesis" EXACT []
is_obsolete: true
consider: GO:0040002
consider: GO:0040003

[Term]
id: GO:0007593
name: chitin-based cuticle sclerotization
namespace: biological_process
alt_id: GO:0045452
def: "The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu]
synonym: "chitin-based cuticle tanning" RELATED [GOC:bf, GOC:dos, GOC:sart]
synonym: "cuticle hardening" NARROW []
is_a: GO:0007591 ! molting cycle, chitin-based cuticle
is_a: GO:0021700 ! developmental maturation
is_a: GO:0022404 ! molting cycle process

[Term]
id: GO:0007594
name: puparial adhesion
namespace: biological_process
def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma]
synonym: "puparial glue" RELATED []
is_a: GO:0022609 ! multicellular organism adhesion to substrate
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0007595
name: lactation
namespace: biological_process
def: "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young." [ISBN:0198506732]
synonym: "milk secretion" EXACT [GOC:pr]
xref: Wikipedia:Lactation
is_a: GO:0007589 ! body fluid secretion
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0007596
name: blood coagulation
namespace: biological_process
def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [PMID:30700128]
synonym: "blood clotting" EXACT []
xref: Wikipedia:Coagulation
is_a: GO:0007599 ! hemostasis
is_a: GO:0050817 ! coagulation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0007597
name: blood coagulation, intrinsic pathway
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde]
comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'.
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation

[Term]
id: GO:0007598
name: blood coagulation, extrinsic pathway
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde]
comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation

[Term]
id: GO:0007599
name: hemostasis
namespace: biological_process
def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732]
xref: Wikipedia:Hemostasis
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007600
name: sensory perception
namespace: biological_process
def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]
subset: goslim_drosophila
xref: Wikipedia:Perception
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0007601
name: visual perception
namespace: biological_process
def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
synonym: "sense of sight" EXACT []
synonym: "sensory visual perception" EXACT []
synonym: "vision" EXACT []
xref: Wikipedia:Visual_perception
is_a: GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0007602
name: phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
synonym: "opsin" RELATED []
synonym: "phototransduction, visible light, light adaptation" NARROW []
synonym: "phototrophin mediated phototransduction" NARROW []
xref: Wikipedia:Visual_phototransduction
is_a: GO:0007165 ! signal transduction
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0007603
name: phototransduction, visible light
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
synonym: "visual cascade" EXACT [PMID:1962207, PMID:9822721]
synonym: "visual transduction" EXACT [PMID:10611962]
is_a: GO:0007602 ! phototransduction
is_a: GO:0009584 ! detection of visible light

[Term]
id: GO:0007604
name: phototransduction, UV
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732]
synonym: "phototransduction, ultraviolet light" EXACT []
synonym: "phototransduction, ultraviolet radiation" EXACT []
synonym: "phototransduction, UV light" EXACT []
synonym: "phototransduction, UV radiation" EXACT []
synonym: "UV-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction
is_a: GO:0009589 ! detection of UV
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0007605
name: sensory perception of sound
namespace: biological_process
def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
synonym: "hearing" EXACT []
synonym: "perception of sound" EXACT []
xref: Wikipedia:Hearing_(sense)
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0007606
name: sensory perception of chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemosensory perception" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0007607
name: obsolete taste perception
namespace: biological_process
def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172]
comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage.
synonym: "taste perception" EXACT []
is_obsolete: true
consider: GO:0050909
consider: GO:0050912

[Term]
id: GO:0007608
name: sensory perception of smell
namespace: biological_process
def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai]
synonym: "olfaction" EXACT []
synonym: "scent perception" EXACT []
synonym: "sense of smell" EXACT []
synonym: "smell perception" EXACT []
xref: Wikipedia:Olfaction
is_a: GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0007610
name: behavior
namespace: biological_process
alt_id: GO:0023032
alt_id: GO:0044708
alt_id: GO:0044709
def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
synonym: "behavioral response to stimulus" EXACT []
synonym: "behaviour" EXACT []
synonym: "behavioural response to stimulus" EXACT []
synonym: "single-organism behavior" RELATED []
xref: Wikipedia:Behavior
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007611
name: learning or memory
namespace: biological_process
def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
is_a: GO:0007610 ! behavior
is_a: GO:0050890 ! cognition

[Term]
id: GO:0007612
name: learning
namespace: biological_process
def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
xref: Wikipedia:Learning
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0007613
name: memory
namespace: biological_process
def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, ISBN:0582227089]
xref: Wikipedia:Memory
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0007614
name: short-term memory
namespace: biological_process
def: "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
xref: Wikipedia:Short-term_memory
is_a: GO:0007613 ! memory

[Term]
id: GO:0007615
name: anesthesia-resistant memory
namespace: biological_process
def: "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
is_a: GO:0007613 ! memory

[Term]
id: GO:0007616
name: long-term memory
namespace: biological_process
def: "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
xref: Wikipedia:Long-term_memory
is_a: GO:0007613 ! memory

[Term]
id: GO:0007617
name: mating behavior
namespace: biological_process
def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
synonym: "mating behaviour" EXACT []
xref: Wikipedia:Mating_behaviour
is_a: GO:0019098 ! reproductive behavior

[Term]
id: GO:0007618
name: mating
namespace: biological_process
def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546]
is_a: GO:0044703 ! multi-organism reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0007619
name: courtship behavior
namespace: biological_process
def: "The behavior of an organism for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
synonym: "courtship behaviour" EXACT []
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0007620
name: copulation
namespace: biological_process
def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544]
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0007621
name: negative regulation of female receptivity
namespace: biological_process
def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827]
synonym: "down regulation of female receptivity" EXACT []
synonym: "down-regulation of female receptivity" EXACT []
synonym: "downregulation of female receptivity" EXACT []
synonym: "inhibition of female receptivity" NARROW []
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0007622
name: rhythmic behavior
namespace: biological_process
def: "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
synonym: "rhythmic behavioral response to stimulus" EXACT []
synonym: "rhythmic behaviour" EXACT []
synonym: "rhythmic behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007623
name: circadian rhythm
namespace: biological_process
alt_id: GO:0050895
def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
subset: goslim_drosophila
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "circadian process" EXACT []
synonym: "circadian response" RELATED []
synonym: "response to circadian rhythm" RELATED []
xref: Wikipedia:Circadian_rhythm
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007624
name: ultradian rhythm
namespace: biological_process
def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, PMID:19708721]
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007625
name: grooming behavior
namespace: biological_process
def: "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr]
synonym: "grooming behaviour" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007626
name: locomotory behavior
namespace: biological_process
def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
subset: goslim_drosophila
synonym: "behavior via locomotion" EXACT []
synonym: "locomotion in response to stimulus" EXACT []
synonym: "locomotory behavioral response to stimulus" EXACT []
synonym: "locomotory behaviour" EXACT []
synonym: "locomotory behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007627
name: obsolete larval behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "larval behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0030537

[Term]
id: GO:0007628
name: adult walking behavior
namespace: biological_process
def: "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
synonym: "adult walking behaviour" EXACT []
is_a: GO:0008344 ! adult locomotory behavior
is_a: GO:0090659 ! walking behavior

[Term]
id: GO:0007629
name: flight behavior
namespace: biological_process
def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
synonym: "flight behaviour" EXACT []
is_a: GO:0008344 ! adult locomotory behavior

[Term]
id: GO:0007630
name: jump response
namespace: biological_process
def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907]
is_a: GO:0008344 ! adult locomotory behavior

[Term]
id: GO:0007631
name: feeding behavior
namespace: biological_process
alt_id: GO:0044366
alt_id: GO:0044367
alt_id: GO:0044368
alt_id: GO:0044369
alt_id: GO:0044370
alt_id: GO:0044371
alt_id: GO:0044372
def: "Behavior associated with the intake of food." [GOC:mah]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "behavioral response to food" EXACT []
synonym: "behavioural response to food" EXACT []
synonym: "eating" NARROW []
synonym: "feeding behaviour" EXACT []
synonym: "feeding from phloem of other organism" NARROW []
synonym: "feeding from plant phloem" NARROW []
synonym: "feeding from tissue of other organism" NARROW []
synonym: "feeding from vascular tissue of another organism" NARROW []
synonym: "feeding from xylem of other organism" NARROW []
synonym: "feeding on blood of other organism" NARROW []
synonym: "feeding on or from other organism" NARROW []
synonym: "feeding on plant sap" NARROW []
synonym: "hematophagy" NARROW []
synonym: "injection of substance into other organism during feeding on blood of other organism" NARROW []
synonym: "taking of blood meal" NARROW []
xref: Wikipedia:List_of_feeding_behaviours
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007632
name: visual behavior
namespace: biological_process
def: "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
synonym: "behavioral response to visual stimulus" EXACT []
synonym: "behavioural response to visual stimulus" EXACT []
synonym: "visual behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0007633
name: pattern orientation
namespace: biological_process
def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535]
synonym: "behavioral response to pattern orientation" EXACT []
synonym: "behavioural response to pattern orientation" EXACT []
is_a: GO:0007632 ! visual behavior

[Term]
id: GO:0007634
name: optokinetic behavior
namespace: biological_process
def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr]
synonym: "optokinetic behaviour" EXACT []
is_a: GO:0007632 ! visual behavior

[Term]
id: GO:0007635
name: chemosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators]
synonym: "behavioral response to chemical stimulus" EXACT []
synonym: "behavioural response to chemical stimulus" EXACT []
synonym: "chemosensory behaviour" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0007636
name: chemosensory jump behavior
namespace: biological_process
def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid]
synonym: "chemosensory jump behaviour" EXACT []
synonym: "jump response to chemical stimulus" EXACT []
is_a: GO:0007630 ! jump response
is_a: GO:0007635 ! chemosensory behavior

[Term]
id: GO:0007637
name: proboscis extension reflex
namespace: biological_process
def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus." [FB:FBrf0044924, GOC:jid]
synonym: "behavioral response to nutritional stimulus, proboscis extension" EXACT []
synonym: "proboscis extension in response to nutritional stimulus" EXACT []
is_a: GO:0007635 ! chemosensory behavior
is_a: GO:0051780 ! behavioral response to nutrient
is_a: GO:0060004 ! reflex

[Term]
id: GO:0007638
name: mechanosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
synonym: "behavioral response to mechanical stimulus" EXACT []
synonym: "behavioural response to mechanical stimulus" EXACT []
synonym: "mechanosensory behaviour" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0007639
name: homeostasis of number of meristem cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem." [GOC:isa_complete]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0008001
name: obsolete fibrinogen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it does not describe an activity.
synonym: "fibrinogen" EXACT []
is_obsolete: true
replaced_by: GO:0005577

[Term]
id: GO:0008002
name: obsolete lamina lucida
namespace: cellular_component
def: "OBSOLETE. The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194]
comment: This term was made obsolete because it is thought to be an experimental artefact.
xref: Wikipedia:Lamina_lucida
is_obsolete: true

[Term]
id: GO:0008004
name: obsolete lamina reticularis
namespace: cellular_component
def: "OBSOLETE. A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194]
comment: This term was obsoleted because as a layer of the basement membrane, the lamina reticularis is thought to be an artefact. See PMID:24137544 and PMID:8061357.
is_obsolete: true
replaced_by: GO:0005604

[Term]
id: GO:0008008
name: obsolete membrane attack complex protein beta2 chain
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "membrane attack complex protein beta2 chain" EXACT []
is_obsolete: true
replaced_by: GO:0005579

[Term]
id: GO:0008009
name: chemokine activity
namespace: molecular_function
def: "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]
subset: goslim_chembl
is_a: GO:0005125 ! cytokine activity
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0008010
name: structural constituent of chitin-based larval cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of larval cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008011
name: structural constituent of pupal chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of pupal cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008012
name: structural constituent of adult chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of adult cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008013
name: beta-catenin binding
namespace: molecular_function
def: "Binding to a catenin beta subunit." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008014
name: obsolete calcium-dependent cell adhesion molecule activity
namespace: molecular_function
alt_id: GO:0001538
def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "cadherin" NARROW []
synonym: "calcium-dependent cell adhesion molecule activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0016339

[Term]
id: GO:0008015
name: blood circulation
namespace: biological_process
alt_id: GO:0070261
def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]
subset: goslim_pir
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0008016
name: regulation of heart contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of cardiac contraction" EXACT []
is_a: GO:1903522 ! regulation of blood circulation
relationship: regulates GO:0060047 ! heart contraction

[Term]
id: GO:0008017
name: microtubule binding
namespace: molecular_function
def: "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]
synonym: "microtubule severing activity" RELATED []
synonym: "microtubule/chromatin interaction" RELATED []
xref: Reactome:R-HSA-9614343 "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs"
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0008018
name: obsolete structural protein of chorion (sensu Drosophila)
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the function is covered by a parent term.
synonym: "structural protein of chorion (sensu Drosophila)" EXACT []
is_obsolete: true
replaced_by: GO:0005213

[Term]
id: GO:0008019
name: obsolete macrophage receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its name is ambiguous, and it was never defined.
synonym: "macrophage receptor activity" EXACT []
is_obsolete: true
consider: GO:0005044
consider: GO:0038187

[Term]
id: GO:0008020
name: G protein-coupled photoreceptor activity
namespace: molecular_function
alt_id: GO:0004975
def: "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]
synonym: "G protein coupled photoreceptor activity" EXACT []
synonym: "G-protein coupled photoreceptor activity" EXACT []
synonym: "photoreceptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0009881 ! photoreceptor activity

[Term]
id: GO:0008021
name: synaptic vesicle
namespace: cellular_component
def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]
comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.
subset: goslim_synapse
synonym: "docked vesicle" NARROW [NIF_Subcellular:sao403156667]
xref: NIF_Subcellular:sao1071221672
xref: Wikipedia:Synaptic_vesicle
is_a: GO:0070382 ! exocytic vesicle
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0008022
name: obsolete protein C-terminus binding
namespace: molecular_function
def: "OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]
comment: It is out of GO scope.
synonym: "C-terminal binding" EXACT []
synonym: "C-terminal end binding" EXACT [GOC:sl]
synonym: "carboxy-terminal binding" RELATED [GOC:jsg]
synonym: "carboxy-terminus binding" RELATED [GOC:sl]
synonym: "carboxyl-terminal binding" RELATED [GOC:jsg]
synonym: "carboxyl-terminus binding" RELATED [GOC:sl]
synonym: "carboxylate-terminal binding" RELATED [GOC:jsg]
synonym: "carboxylate-terminus binding" NARROW [GOC:jsg]
synonym: "COOH-terminal binding" NARROW [GOC:jsg]
synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl]
is_obsolete: true
replaced_by: GO:0005515

[Term]
id: GO:0008023
name: transcription elongation factor complex
namespace: cellular_component
def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
subset: goslim_pir
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0008024
name: cyclin/CDK positive transcription elongation factor complex
namespace: cellular_component
def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit." [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]
comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
synonym: "positive transcription elongation factor complex b" RELATED []
is_a: GO:0008023 ! transcription elongation factor complex
is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex

[Term]
id: GO:0008025
name: obsolete diazepam binding inhibitor activity
namespace: molecular_function
def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732, PMID:11883709]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "DBI" EXACT []
synonym: "diazepam binding inhibitor activity" EXACT []
synonym: "diazepam-binding inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004857
consider: GO:0030156
consider: GO:0050796
consider: GO:0050809
consider: GO:0050810
consider: GO:0050811
consider: GO:0050812

[Term]
id: GO:0008028
name: monocarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008505
def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]
synonym: "monocarboxylate carrier" NARROW []
synonym: "prostaglandin/thromboxane transporter activity" NARROW []
xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol"
xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0008029
name: pentraxin receptor activity
namespace: molecular_function
def: "Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
synonym: "pentaxin receptor" EXACT []
is_a: GO:0001847 ! opsonin receptor activity

[Term]
id: GO:0008030
name: neuronal pentraxin receptor activity
namespace: molecular_function
def: "Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:18840757]
synonym: "neuronal pentaxin receptor" EXACT []
is_a: GO:0008029 ! pentraxin receptor activity

[Term]
id: GO:0008031
name: eclosion hormone activity
namespace: molecular_function
def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0008033
name: tRNA processing
namespace: biological_process
def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
subset: goslim_yeast
synonym: "tRNA maturation" EXACT [GOC:vw]
is_a: GO:0006396 ! RNA processing
is_a: GO:0006399 ! tRNA metabolic process

[Term]
id: GO:0008034
name: obsolete lipoprotein binding
namespace: molecular_function
def: "OBSOLETE. Binding to a conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because its text definition and implicit ontology-structure definition disagreed, and as a result the term had been used in annotations with more than one meaning.
synonym: "lipoprotein binding" EXACT []
is_obsolete: true
consider: GO:0071723
consider: GO:0071813

[Term]
id: GO:0008035
name: high-density lipoprotein particle binding
namespace: molecular_function
def: "Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE." [GOC:mah]
synonym: "HDL binding" EXACT [GOC:mah]
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0008036
name: diuretic hormone receptor activity
namespace: molecular_function
def: "Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0008037
name: cell recognition
namespace: biological_process
def: "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators]
subset: goslim_pir
synonym: "recognition of surroundings by cell" EXACT []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0008038
name: neuron recognition
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
synonym: "neuronal cell recognition" EXACT []
is_a: GO:0008037 ! cell recognition
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0008039
name: synaptic target recognition
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
subset: goslim_synapse
synonym: "neuronal targeting" EXACT []
is_a: GO:0008038 ! neuron recognition

[Term]
id: GO:0008041
name: obsolete storage protein of fat body (sensu Insecta)
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular location rather than a function.
synonym: "storage protein of fat body (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0045735

[Term]
id: GO:0008042
name: obsolete iron-sulfur electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "ferredoxin" NARROW []
synonym: "iron-sulfur electron transfer carrier" EXACT []
synonym: "iron-sulphur electron transfer carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0008043
name: obsolete intracellular ferritin complex
namespace: cellular_component
def: "OBSOLETE. A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717]
comment: The reason for obsoletion is that this term represents a cellular component and its location.
is_obsolete: true
replaced_by: GO:0070288

[Term]
id: GO:0008044
name: obsolete adult behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "adult behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0030534

[Term]
id: GO:0008045
name: motor neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
synonym: "motoneuron axon guidance" EXACT []
synonym: "motor axon guidance" EXACT []
synonym: "motor axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0008046
name: axon guidance receptor activity
namespace: molecular_function
def: "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]
synonym: "receptor activity involved in axon guidance" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0008047
name: enzyme activator activity
namespace: molecular_function
alt_id: GO:0010577
def: "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]
comment: This term should only be used in cases when the regulator directly interacts with the enzyme.
synonym: "metalloenzyme activator activity" NARROW []
is_a: GO:0030234 ! enzyme regulator activity
is_a: GO:0140677 ! molecular function activator activity

[Term]
id: GO:0008048
name: calcium sensitive guanylate cyclase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah]
is_a: GO:0030250 ! guanylate cyclase activator activity

[Term]
id: GO:0008049
name: male courtship behavior
namespace: biological_process
alt_id: GO:0016542
def: "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
synonym: "male courtship behaviour" EXACT []
is_a: GO:0007619 ! courtship behavior
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0008050
name: female courtship behavior
namespace: biological_process
def: "The behavior of a female, for the purpose of attracting a sexual partner." [GOC:bf, GOC:pr]
synonym: "female courtship behaviour" EXACT []
is_a: GO:0007619 ! courtship behavior
is_a: GO:0060180 ! female mating behavior

[Term]
id: GO:0008051
name: obsolete farnesyl-diphosphate farnesyl transferase complex
namespace: cellular_component
def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah]
comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer.
synonym: "farnesyl-diphosphate farnesyl transferase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0008052
name: sensory organ boundary specification
namespace: biological_process
def: "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021]
synonym: "sense organ boundary specification" EXACT [GOC:dph]
is_a: GO:0010160 ! formation of animal organ boundary
relationship: part_of GO:0007423 ! sensory organ development

[Term]
id: GO:0008053
name: mitochondrial fusion
namespace: biological_process
alt_id: GO:1990613
def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]
synonym: "mitochondrial membrane fusion" RELATED []
synonym: "mitochondrion fusion" EXACT []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0048284 ! organelle fusion

[Term]
id: GO:0008055
name: ocellus pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706]
synonym: "ocellus pigment anabolism" EXACT []
synonym: "ocellus pigment biosynthesis" EXACT []
synonym: "ocellus pigment formation" EXACT []
synonym: "ocellus pigment synthesis" EXACT []
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046158 ! ocellus pigment metabolic process

[Term]
id: GO:0008056
name: ocellus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0008057
name: eye pigment granule organization
namespace: biological_process
alt_id: GO:0008059
alt_id: GO:0045318
alt_id: GO:0048751
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
synonym: "eye pigment granule organisation" EXACT [GOC:mah]
synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0008058
name: ocellus pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm]
synonym: "ocellus pigment granule organisation" EXACT []
synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0008061
name: chitin binding
namespace: molecular_function
def: "Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
subset: goslim_drosophila
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0008062
name: eclosion rhythm
namespace: biological_process
def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
is_a: GO:0048512 ! circadian behavior
relationship: part_of GO:0007562 ! eclosion

[Term]
id: GO:0008063
name: Toll signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
synonym: "Tl signaling pathway" EXACT []
synonym: "Tl signalling pathway" EXACT []
synonym: "Toll signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0008064
name: regulation of actin polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
is_a: GO:0030832 ! regulation of actin filament length
is_a: GO:0110053 ! regulation of actin filament organization
relationship: regulates GO:0008154 ! actin polymerization or depolymerization

[Term]
id: GO:0008065
name: establishment of blood-nerve barrier
namespace: biological_process
def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh]
synonym: "establishment of blood/nerve barrier" EXACT []
is_a: GO:0001885 ! endothelial cell development
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0008066
name: glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0008067
name: obsolete metabotropic glutamate, GABA-B-like receptor activity
namespace: molecular_function
alt_id: GO:0001643
alt_id: GO:0001645
def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "class C G protein coupled receptor" BROAD []
synonym: "class C G-protein coupled receptor" BROAD []
synonym: "class C GPCR" BROAD []
synonym: "class C orphan receptor activity" EXACT []
synonym: "metabotropic glutamate, GABA-B-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0008068
name: extracellularly glutamate-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
synonym: "extracellular-glutamate-gated chloride channel activity" EXACT []
is_a: GO:0005234 ! extracellularly glutamate-gated ion channel activity
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity

[Term]
id: GO:0008069
name: dorsal/ventral axis specification, ovarian follicular epithelium
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb]
synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah]
synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED []
synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb]
synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009950 ! dorsal/ventral axis specification
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0008070
name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah]
synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah]
is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium

[Term]
id: GO:0008071
name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah]
synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD []
synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah]
is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium

[Term]
id: GO:0008073
name: ornithine decarboxylase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of ornithine decarboxylase." [GOC:jl]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0042979 ! ornithine decarboxylase regulator activity

[Term]
id: GO:0008074
name: guanylate cyclase complex, soluble
namespace: cellular_component
def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]
comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'.
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0008075
name: obsolete receptor guanylate cyclase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "receptor guanylate cyclase activity" EXACT []
is_obsolete: true
consider: GO:0004383
consider: GO:0038023

[Term]
id: GO:0008076
name: voltage-gated potassium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
synonym: "voltage gated potassium channel complex" EXACT []
synonym: "voltage-dependent potassium channel complex" EXACT []
synonym: "voltage-sensitive potassium channel complex" EXACT []
xref: NIF_Subcellular:sao371494298
is_a: GO:0034705 ! potassium channel complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0008077
name: obsolete Hsp70/Hsp90 organizing protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:rb]
comment: This term was made obsolete because it represents a specific gene product rather than a molecular function.
synonym: "Hsp70/Hsp90 organising protein activity" EXACT []
synonym: "Hsp70/Hsp90 organizing protein activity" EXACT []
is_obsolete: true
consider: GO:0030674

[Term]
id: GO:0008078
name: mesodermal cell migration
namespace: biological_process
def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]
synonym: "mesoderm cell migration" EXACT []
is_a: GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0008079
name: translation termination factor activity
namespace: molecular_function
def: "Functions in the termination of translation." [GOC:ma]
is_a: GO:0008135 ! translation factor activity, RNA binding

[Term]
id: GO:0008080
name: N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
xref: Reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2"
xref: Reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2"
xref: Reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842"
xref: Reactome:R-HSA-9636560 "Eis acetylates DUSP16"
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0008081
name: phosphoric diester hydrolase activity
namespace: molecular_function
alt_id: GO:0004434
alt_id: GO:0016792
def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]
subset: goslim_chembl
synonym: "phosphodiesterase" NARROW []
xref: EC:3.1.4.-
xref: Reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends"
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0008083
name: growth factor activity
namespace: molecular_function
def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]
comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.
subset: goslim_chembl
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0008084
name: imaginal disc growth factor receptor binding
namespace: molecular_function
def: "Binding to an imaginal disc growth factor receptor." [GOC:mah]
synonym: "imaginal disc growth factor" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0008085
name: obsolete phototransduction, visible light, light adaptation
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term name is ambiguous.
synonym: "phototransduction, visible light, light adaptation" EXACT []
is_obsolete: true
consider: GO:0007602

[Term]
id: GO:0008086
name: light-activated voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport]
synonym: "light-activated voltage gated calcium channel activity" EXACT []
synonym: "light-activated voltage-dependent calcium channel activity" EXACT []
is_a: GO:0005245 ! voltage-gated calcium channel activity
is_a: GO:0010461 ! light-activated monoatomic ion channel activity

[Term]
id: GO:0008087
name: light-activated voltage-gated calcium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679]
synonym: "light-activated voltage gated calcium channel complex" EXACT []
synonym: "light-activated voltage-dependent calcium channel complex" EXACT []
synonym: "light-activated voltage-sensitive calcium channel complex" EXACT []
is_a: GO:0005891 ! voltage-gated calcium channel complex

[Term]
id: GO:0008088
name: axo-dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" NARROW []
synonym: "axonal transport" NARROW []
synonym: "axoplasmic transport" NARROW []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0010970 ! transport along microtubule

[Term]
id: GO:0008089
name: anterograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" EXACT []
is_a: GO:0098930 ! axonal transport

[Term]
id: GO:0008090
name: retrograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" EXACT []
is_a: GO:0098930 ! axonal transport

[Term]
id: GO:0008091
name: spectrin
namespace: cellular_component
def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194]
xref: NIF_Subcellular:sao536287099
xref: Wikipedia:Spectrin
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0008092
name: cytoskeletal protein binding
namespace: molecular_function
def: "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_prokaryote
subset: goslim_yeast
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008093
name: cytoskeletal anchor activity
namespace: molecular_function
def: "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]
synonym: "cytoskeletal adaptor activity" EXACT []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0008094
name: ATP-dependent activity, acting on DNA
namespace: molecular_function
alt_id: GO:0004011
def: "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]
synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT []
synonym: "ATPase activity, acting on DNA" EXACT []
synonym: "ATPase, acting on DNA" EXACT []
synonym: "DNA dependent ATPase activity" EXACT []
synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT []
synonym: "DNA-dependent ATPase activity" EXACT []
is_a: GO:0140097 ! catalytic activity, acting on DNA
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0008096
name: juvenile hormone epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol." [GOC:mah, PMID:8396141]
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0008097
name: 5S rRNA binding
namespace: molecular_function
def: "Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0008098
name: 5S rRNA primary transcript binding
namespace: molecular_function
def: "Binding to an unprocessed 5S ribosomal RNA transcript." [GOC:jl]
is_a: GO:0008097 ! 5S rRNA binding

[Term]
id: GO:0008100
name: obsolete lipophorin
namespace: molecular_function
def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "lipophorin" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0008103
name: oocyte microtubule cytoskeleton polarization
namespace: biological_process
alt_id: GO:0048129
def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
is_a: GO:0007017 ! microtubule-based process
relationship: part_of GO:0007309 ! oocyte axis specification
relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization

[Term]
id: GO:0008104
name: protein localization
namespace: biological_process
alt_id: GO:0008105
alt_id: GO:0016249
alt_id: GO:0034613
def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
subset: goslim_drosophila
synonym: "asymmetric protein localisation" RELATED [GOC:mah]
synonym: "asymmetric protein localization" RELATED []
synonym: "cellular protein localisation" EXACT [GOC:mah]
synonym: "cellular protein localization" EXACT []
synonym: "channel localizer activity" NARROW [GOC:mah]
synonym: "establishment and maintenance of asymmetric protein localization" RELATED []
synonym: "establishment and maintenance of protein localization" RELATED []
synonym: "protein localisation" EXACT [GOC:mah]
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0008106
name: alcohol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or ketone + NADPH + H+." [EC:1.1.1.2]
synonym: "alcohol:NADP dehydrogenase activity" EXACT []
synonym: "aldehyde reductase (NADPH) activity" EXACT []
synonym: "NADP-aldehyde reductase activity" EXACT []
xref: EC:1.1.1.2
is_a: GO:0004033 ! aldo-keto reductase (NADPH) activity

[Term]
id: GO:0008107
name: galactoside 2-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69, RHEA:50664]
synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT []
synonym: "alpha-(1->2)-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "alpha-2-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "alpha-2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "galactoside 2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "GDP fucose-lactose fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "GDP-L-fucose:lactose fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69]
synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69]
xref: EC:2.4.1.69
xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-9036987 "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec"
xref: Reactome:R-HSA-9603982 "FUT2 transfers Fuc to LeA to form LeB"
xref: Reactome:R-HSA-9603983 "FUT2 transfers Fuc to LeX to form LeY"
xref: RHEA:50664
is_a: GO:0031127 ! alpha-(1,2)-fucosyltransferase activity

[Term]
id: GO:0008108
name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13989]
synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12]
synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12]
synonym: "hexose 1-phosphate uridyltransferase activity" RELATED [EC:2.7.7.12]
synonym: "hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12]
synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12]
synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12]
synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12]
synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12]
synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12]
synonym: "uridyltransferase activity" BROAD [EC:2.7.7.12]
synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12]
xref: EC:2.7.7.12
xref: KEGG_REACTION:R00955
xref: MetaCyc:GALACTURIDYLYLTRANS-RXN
xref: Reactome:R-HSA-5610038 "Defective GALT does not transfer UMP to Gal1P"
xref: Reactome:R-HSA-70361 "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal"
xref: RHEA:13989
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0008109
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150]
synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.150]
synonym: "N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.150]
synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" RELATED [EC:2.4.1.150]
synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.150]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.150]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150]
xref: EC:2.4.1.150
xref: MetaCyc:2.4.1.150-RXN
xref: RHEA:54820
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008110
name: L-histidine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate." [EC:2.6.1.38, RHEA:16565]
synonym: "histidine aminotransferase activity" BROAD []
synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38]
synonym: "histidine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.38]
xref: EC:2.6.1.38
xref: KEGG_REACTION:R01161
xref: MetaCyc:HISTTRANSAM-RXN
xref: RHEA:16565
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008111
name: alpha-methylacyl-CoA racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4]
synonym: "2-methylacyl-CoA 2-epimerase activity" RELATED [EC:5.1.99.4]
xref: EC:5.1.99.4
xref: MetaCyc:5.1.99.4-RXN
xref: Reactome:R-HSA-192056 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA"
xref: Reactome:R-HSA-193452 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA"
xref: Reactome:R-HSA-193736 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA"
xref: Reactome:R-HSA-193763 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA"
xref: Reactome:R-HSA-389897 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA"
xref: RHEA:12657
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0008112
name: nicotinamide N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine." [EC:2.1.1.1, RHEA:23884]
synonym: "nicotinamide methyltransferase activity" RELATED [EC:2.1.1.1]
synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" RELATED [EC:2.1.1.1]
xref: EC:2.1.1.1
xref: KEGG_REACTION:R01269
xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-5359451 "NNMT transfers CH3 from SAM to NAM to form MNA"
xref: RHEA:23884
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008113
name: peptide-methionine (S)-S-oxide reductase activity
namespace: molecular_function
alt_id: GO:0033742
alt_id: GO:0072561
def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920]
synonym: "methionine S-oxide reductase (S-form oxidizing) activity" RELATED [EC:1.8.4.11]
synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11]
synonym: "methionine sulfoxide (protein) reductase activity" EXACT []
synonym: "methionine sulfoxide reductase A activity" RELATED [EC:1.8.4.11]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11]
synonym: "methionine sulphoxide reductase A activity" RELATED [EC:1.8.4.11]
synonym: "MsrA" RELATED [EC:1.8.4.11]
synonym: "peptide Met(O) reductase activity" RELATED [EC:1.8.4.11]
synonym: "peptide methionine sulfoxide reductase activity" RELATED [EC:1.8.4.11]
synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" RELATED [EC:1.8.4.11]
synonym: "peptide-methionine-(S)-S-oxide reductase activity" EXACT []
synonym: "protein-methionine-S-oxide reductase activity" EXACT []
xref: EC:1.8.4.11
xref: MetaCyc:RXN-8668
xref: Reactome:R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides"
xref: Reactome:R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine"
xref: RHEA:14217
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0008114
name: phosphogluconate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43]
synonym: "2-keto-6-phosphogluconate reductase activity" RELATED [EC:1.1.1.43]
synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.43]
synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT []
synonym: "6-phosphogluconate dehydrogenase (NAD)" RELATED [EC:1.1.1.43]
synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43]
synonym: "gluconate 6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.43]
synonym: "phosphogluconate dehydrogenase activity" RELATED [EC:1.1.1.43]
xref: EC:1.1.1.43
xref: MetaCyc:1.1.1.43-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008115
name: sarcosine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2." [EC:1.5.3.1, RHEA:13313]
synonym: "sarcosine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.1]
xref: EC:1.5.3.1
xref: KEGG_REACTION:R00610
xref: MetaCyc:SARCOX-RXN
xref: RHEA:13313
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0008116
name: prostaglandin-I synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)." [EC:5.3.99.4, RHEA:23580]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" RELATED [EC:5.3.99.4]
synonym: "cytochrome P450 CYP8A1" NARROW []
synonym: "PGI(2) synthase activity" RELATED [EC:5.3.99.4]
synonym: "PGI(2) synthetase activity" RELATED [EC:5.3.99.4]
synonym: "PGI2 synthase activity" RELATED [EC:5.3.99.4]
synonym: "PGI2 synthetase activity" RELATED [EC:5.3.99.4]
synonym: "prostacyclin synthase activity" RELATED [EC:5.3.99.4]
synonym: "prostacycline synthetase activity" RELATED [EC:5.3.99.4]
synonym: "prostagladin I2 synthetase activity" RELATED [EC:5.3.99.4]
xref: EC:5.3.99.4
xref: KEGG_REACTION:R02267
xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN
xref: Reactome:R-HSA-76496 "PTGIS, CYP8A1 isomerise PGH2 to PGI2"
xref: RHEA:23580
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0008117
name: sphinganine-1-phosphate aldolase activity
namespace: molecular_function
alt_id: GO:0016001
def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27]
synonym: "dihydrosphingosine 1-phosphate aldolase activity" RELATED [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate alkanal-lyase activity" RELATED [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate lyase activity" RELATED [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" RELATED [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" RELATED [EC:4.1.2.27]
synonym: "sphingosine-1-phosphate aldolase activity" RELATED [EC:4.1.2.27]
synonym: "sphingosine-1-phosphate lyase activity" RELATED [EC:4.1.2.27]
xref: EC:4.1.2.27
xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN
xref: Reactome:R-HSA-428681 "PXLP-SGPL1 cleaves sphingoid-1-phosphates"
xref: RHEA:18593
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008118
name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H+." [PMID:10206952, RHEA:52316]
comment: The substrate for this reaction is a beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
synonym: "alpha2->3 sialyltransferase activity" RELATED [EC:2.4.3.6]
synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" RELATED [EC:2.4.3.6]
synonym: "N-acetyllactosaminide alpha-2,3-sialyltransferase" EXACT [EC:2.4.3.6]
synonym: "neolactotetraosylceramide alpha-2,3-sialyltransferase activity" NARROW [EC:2.4.3.6]
xref: EC:2.4.3.6
xref: MetaCyc:2.4.99.6-RXN
xref: RHEA:52316
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0008119
name: thiopurine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]
synonym: "6-thiopurine transmethylase activity" RELATED [EC:2.1.1.67]
synonym: "mercaptopurine methyltransferase activity" RELATED [EC:2.1.1.67]
synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" RELATED [EC:2.1.1.67]
synonym: "thiopurine methyltransferase activity" RELATED [EC:2.1.1.67]
synonym: "TPMT" RELATED [EC:2.1.1.67]
xref: EC:2.1.1.67
xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-158609 "TPMT transfers CH3 from AdoMet to 6MP"
xref: Reactome:R-HSA-5603379 "TPMT does not transfer CH3 from AdoMet to 6MP"
xref: Reactome:R-HSA-9748979 "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP"
xref: Reactome:R-HSA-9748983 "TPMT transfers methyl group to 6MP, forming 6MeMP"
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008120
name: ceramide glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H+ + UDP." [RHEA:12088]
synonym: "ceramide:UDP-glucose glucosyltransferase activity" RELATED [EC:2.4.1.80]
synonym: "ceramide:UDPGlc glucosyltransferase activity" RELATED [EC:2.4.1.80]
synonym: "glucosylceramide synthase activity" RELATED [EC:2.4.1.80]
synonym: "UDP-glucose-ceramide glucosyltransferase activity" RELATED [EC:2.4.1.80]
synonym: "UDP-glucose:ceramide glucosyltransferase activity" RELATED [EC:2.4.1.80]
synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" RELATED [EC:2.4.1.80]
synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" RELATED [EC:2.4.1.80]
synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" RELATED [EC:2.4.1.80]
xref: EC:2.4.1.80
xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-1638104 "UGCG transfers glucose to ceramide"
xref: RHEA:12088
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008121
name: ubiquinol-cytochrome-c reductase activity
namespace: molecular_function
alt_id: GO:0045153
alt_id: GO:0045154
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [RHEA:11484]
synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:7.1.1.8]
synonym: "cytochrome" BROAD []
synonym: "cytochrome a" NARROW []
synonym: "cytochrome a3/copper complex" NARROW []
synonym: "cytochrome b562" NARROW []
synonym: "cytochrome b566" NARROW []
synonym: "cytochrome c1" NARROW []
synonym: "electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity" RELATED []
synonym: "electron transporter, transferring electrons within cytochrome c oxidase complex activity" RELATED []
synonym: "mitochondrial electron transport complex III" RELATED []
synonym: "soluble cytochrome b562" NARROW []
synonym: "ubiquinol-cytochrome c oxidoreductase activity" RELATED []
synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" RELATED []
synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" RELATED []
synonym: "ubiquinol-cytochrome c2 reductase activity" RELATED []
synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" RELATED []
synonym: "ubiquinone--cytochrome-c oxidoreductase activity" RELATED [EC:7.1.1.8]
synonym: "ubiquinone-cytochrome c oxidoreductase activity" RELATED [EC:7.1.1.8]
synonym: "ubiquinone-cytochrome c reductase activity" RELATED [EC:7.1.1.8]
xref: EC:7.1.1.8
xref: MetaCyc:RXN-15816
xref: Reactome:R-HSA-164651 "Electron transfer from ubiquinol to cytochrome c of complex III"
xref: RHEA:11484
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0008123
name: cholesterol 7-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:21812]
synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT []
synonym: "cholesterol 7alpha-hydroxylase activity" RELATED [EC:1.14.14.23]
synonym: "cholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.23]
synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" RELATED [EC:1.14.14.23]
synonym: "cytochrome P450 CYP7A1" NARROW []
xref: EC:1.14.14.23
xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-192051 "CYP7A1 7-hydroxylates CHOL"
xref: RHEA:21812
is_a: GO:0008387 ! steroid 7-alpha-hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008124
name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96, RHEA:11920]
synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96]
synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" RELATED [EC:4.2.1.96]
synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT []
synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" RELATED [EC:4.2.1.96]
synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" RELATED [EC:4.2.1.96]
synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT []
synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT []
synonym: "pterin-4alpha-carbinolamine dehydratase activity" RELATED []
synonym: "tetrahydrobiopterin dehydratase activity" RELATED [EC:4.2.1.96]
xref: EC:4.2.1.96
xref: KEGG_REACTION:R04734
xref: MetaCyc:RXN-7908
xref: Reactome:R-HSA-71146 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O"
xref: RHEA:11920
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008125
name: obsolete pancreatic elastase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "elaszym" RELATED []
synonym: "pancreatic elastase I activity" EXACT []
synonym: "pancreatopeptidase E activity" RELATED []
synonym: "serine elastase" BROAD []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008126
name: acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6]
synonym: "acetic ester hydrolase activity" RELATED [EC:3.1.1.6]
synonym: "acetic-ester acetylhydrolase activity" RELATED [EC:3.1.1.6]
synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6]
synonym: "chloroesterase" NARROW [EC:3.1.1.6]
synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6]
synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6]
xref: EC:3.1.1.6
xref: MetaCyc:ACETYLESTERASE-RXN
xref: RHEA:12957
xref: UM-BBD_reactionID:r0170
is_a: GO:0034338 ! short-chain carboxylesterase activity

[Term]
id: GO:0008127
name: quercetin 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO." [EC:1.13.11.24, RHEA:15381]
synonym: "flavonol 2,4-oxygenase activity" RELATED [EC:1.13.11.24]
synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.24]
synonym: "quercetinase activity" RELATED [EC:1.13.11.24]
xref: EC:1.13.11.24
xref: KEGG_REACTION:R02156
xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN
xref: Reactome:R-HSA-8953398 "PIR oxygenates quercetin"
xref: RHEA:15381
xref: UM-BBD_reactionID:r0891
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0008129
name: obsolete actinidain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14]
comment: This term was made obsolete because it represents a gene product.
synonym: "actinidain activity" EXACT []
synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14]
synonym: "actinidin activity" RELATED [EC:3.4.22.14]
synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14]
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0008130
name: obsolete neutrophil collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 8 activity" RELATED []
synonym: "MMP-8" EXACT []
synonym: "neutrophil collagenase activity" EXACT []
synonym: "PMNL collagenase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008131
name: primary methylamine oxidase activity
namespace: molecular_function
alt_id: GO:0004041
alt_id: GO:0008122
def: "Catalysis of the reaction: a primary methyl amine + H2O + O2 = an aldehyde + H2O2 + NH4+." [RHEA:16153]
synonym: "amine oxidase (copper-containing) activity" NARROW []
synonym: "amine oxidase activity" BROAD [EC:1.4.3.21]
synonym: "primary amine oxidase activity" RELATED []
synonym: "primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.21]
xref: EC:1.4.3.21
xref: KEGG_REACTION:R01853
xref: MetaCyc:RXN-9597
xref: Reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT"
xref: Reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA"
xref: Reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR"
xref: Reactome:R-HSA-374909 "Catabolism of Noradrenaline"
xref: Reactome:R-HSA-379382 "MAOA:FAD deaminates DA to DOPAC"
xref: Reactome:R-HSA-379395 "MAOA:FAD deaminates 3MT to HVA"
xref: Reactome:R-HSA-5603108 "Defective MAOA does not oxidatively deaminate 5HT"
xref: Reactome:R-HSA-5696146 "AOC2 deaminates TYR"
xref: Reactome:R-HSA-5696183 "AOC3 deaminates BZAM"
xref: RHEA:16153
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0008132
name: obsolete pancreatic elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "pancreatic elastase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008133
name: obsolete collagenase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagenase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008134
name: transcription factor binding
namespace: molecular_function
def: "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]
comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "TF binding" EXACT []
synonym: "transcription regulator binding" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008135
name: translation factor activity, RNA binding
namespace: molecular_function
def: "Functions during translation by binding to RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw]
subset: goslim_chembl
subset: goslim_plant
subset: goslim_yeast
synonym: "translation factor activity, nucleic acid binding" BROAD [GOC:mah]
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding

[Term]
id: GO:0008137
name: NADH dehydrogenase (ubiquinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out)." [RHEA:29091]
synonym: "coenzyme Q reductase activity" RELATED [EC:7.1.1.2]
synonym: "complex 1 dehydrogenase activity" RELATED [EC:7.1.1.2]
synonym: "complex I (electron transport chain) activity" RELATED [EC:7.1.1.2]
synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:7.1.1.2]
synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:7.1.1.2]
synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" RELATED [EC:7.1.1.2]
synonym: "DPNH-coenzyme Q reductase activity" RELATED [EC:7.1.1.2]
synonym: "DPNH-ubiquinone reductase activity" RELATED [EC:7.1.1.2]
synonym: "electron transfer complex I activity" RELATED [EC:7.1.1.2]
synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:7.1.1.2]
synonym: "mitochondrial electron transport complex I activity" NARROW [EC:7.1.1.2]
synonym: "NADH coenzyme Q1 reductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-coenzyme Q oxidoreductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-coenzyme Q reductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-CoQ oxidoreductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-CoQ reductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-Q6 oxidoreductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-ubiquinone oxidoreductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-ubiquinone reductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH-ubiquinone-1 reductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH:ubiquinone oxidoreductase activity" RELATED [EC:7.1.1.2]
synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:7.1.1.2]
synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" RELATED [EC:7.1.1.2]
synonym: "type 1 dehydrogenase activity" RELATED [EC:7.1.1.2]
synonym: "ubiquinone reductase activity" EXACT []
xref: EC:7.1.1.2
xref: MetaCyc:NADH-DEHYDROG-A-RXN
xref: Reactome:R-HSA-163217 "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2"
xref: RHEA:29091
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0008138
name: protein tyrosine/serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
synonym: "dual-specificity protein phosphatase" BROAD []
xref: Reactome:R-HSA-5675373 "Nuclear DUSPs dephosphorylate MAPKs"
xref: Reactome:R-HSA-5675376 "Cytosolic DUSPs dephosphorylate MAPKs"
xref: Reactome:R-HSA-9652816 "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs"
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0008139
name: nuclear localization sequence binding
namespace: molecular_function
def: "Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]
synonym: "NLS binding" EXACT []
synonym: "nuclear localisation sequence binding" EXACT [GOC:mah]
synonym: "nuclear localization signal binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0008140
name: cAMP response element binding protein binding
namespace: molecular_function
def: "Binding to a cAMP response element binding protein (a CREB protein)." [GOC:mah]
synonym: "3',5' cAMP response element binding protein binding" EXACT []
synonym: "3',5'-cAMP response element binding protein binding" EXACT []
synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT []
synonym: "CBP" RELATED [GOC:bf]
synonym: "CREB binding" EXACT []
synonym: "cyclic AMP response element binding protein binding" EXACT []
is_a: GO:0140297 ! DNA-binding transcription factor binding

[Term]
id: GO:0008141
name: obsolete puparial glue (sensu Diptera)
namespace: molecular_function
def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "puparial glue (sensu Diptera)" EXACT []
is_obsolete: true
consider: GO:0005198
consider: GO:0007594

[Term]
id: GO:0008142
name: oxysterol binding
namespace: molecular_function
def: "Binding to oxysterol, an oxidized form of cholesterol." [GOC:curators]
is_a: GO:0032934 ! sterol binding

[Term]
id: GO:0008143
name: poly(A) binding
namespace: molecular_function
def: "Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]
synonym: "poly(A) binding, within an RNA molecule" EXACT []
synonym: "poly(rA) binding" EXACT [GOC:mah]
synonym: "poly-A binding" EXACT [GOC:mah]
synonym: "polyadenylate binding" EXACT [GOC:mah]
is_a: GO:0070717 ! poly-purine tract binding

[Term]
id: GO:0008144
name: obsolete drug binding
namespace: molecular_function
def: "OBSOLETE. Binding to a drug, a naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism;typically used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732]
comment: It is not meaningful to describe a molecular function by what role a compound may be used for at some times.
is_obsolete: true

[Term]
id: GO:0008145
name: phenylalkylamine binding
namespace: molecular_function
def: "Binding to phenylalkylamine or one of its derivatives." [GOC:jl]
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0008146
name: sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2.-]
subset: goslim_chembl
synonym: "sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: Reactome:R-HSA-176588 "lithocholate + PAPS => lithocholate sulfate + PAP"
xref: Reactome:R-HSA-176604 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP"
xref: Reactome:R-HSA-176669 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP"
xref: Reactome:R-HSA-2022061 "Dermatan sulfate can be further sulfated on position 2 of iduronate"
xref: Reactome:R-HSA-9753277 "SULT dimers sulfate APAP to APAP-SO3"
is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups

[Term]
id: GO:0008147
name: structural constituent of bone
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008148
name: obsolete negative transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "negative transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0032785

[Term]
id: GO:0008149
name: obsolete para-aminobenzoic acid (PABA) synthase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX]
comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered.
synonym: "para-aminobenzoic acid (PABA) synthase" EXACT []
is_obsolete: true
consider: GO:0008696
consider: GO:0046820

[Term]
id: GO:0008150
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
alt_id: GO:0044699
def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
synonym: "biological process" EXACT []
synonym: "physiological process" EXACT []
synonym: "single organism process" RELATED []
synonym: "single-organism process" RELATED []
xref: Wikipedia:Biological_process

[Term]
id: GO:0008152
name: metabolic process
namespace: biological_process
alt_id: GO:0044236
alt_id: GO:0044710
def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well  macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote_ribbon
synonym: "metabolism" EXACT []
xref: Wikipedia:Metabolism
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0008153
name: 4-aminobenzoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]
synonym: "4-aminobenzoic acid biosynthesis" EXACT []
synonym: "4-aminobenzoic acid biosynthetic process" EXACT []
synonym: "p-aminobenzoic acid biosynthesis" EXACT []
synonym: "p-aminobenzoic acid biosynthetic process" EXACT []
synonym: "PABA biosynthesis" EXACT []
synonym: "PABA biosynthetic process" EXACT []
synonym: "para-aminobenzoic acid anabolism" EXACT []
synonym: "para-aminobenzoic acid biosynthesis" EXACT []
synonym: "para-aminobenzoic acid biosynthetic process" EXACT []
synonym: "para-aminobenzoic acid formation" EXACT []
synonym: "para-aminobenzoic acid synthesis" EXACT []
synonym: "vitamin Bx biosynthesis" EXACT []
synonym: "vitamin Bx biosynthetic process" EXACT []
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0046482 ! para-aminobenzoic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0008154
name: actin polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0008155
name: obsolete larval behavior (sensu Drosophila)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
synonym: "larval behavior (sensu Drosophila)" EXACT []
is_obsolete: true
replaced_by: GO:0030537

[Term]
id: GO:0008156
name: negative regulation of DNA replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators]
synonym: "DNA replication inhibitor" RELATED []
synonym: "down regulation of DNA replication" EXACT []
synonym: "down-regulation of DNA replication" EXACT []
synonym: "downregulation of DNA replication" EXACT []
synonym: "inhibition of DNA replication" NARROW []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0006260 ! DNA replication

[Term]
id: GO:0008157
name: protein phosphatase 1 binding
namespace: molecular_function
def: "Binding to a protein phosphatase 1." [GOC:jl]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0008158
name: hedgehog receptor activity
namespace: molecular_function
def: "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]
synonym: "patched activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0008159
name: obsolete positive transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "positive transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0032786

[Term]
id: GO:0008160
name: protein tyrosine phosphatase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732]
is_a: GO:0072542 ! protein phosphatase activator activity

[Term]
id: GO:0008161
name: obsolete carbamate resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "carbamate resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046681

[Term]
id: GO:0008162
name: obsolete cyclodiene resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "cyclodiene resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046682

[Term]
id: GO:0008163
name: obsolete DDT resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "DDT resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046680

[Term]
id: GO:0008164
name: obsolete organophosphorus resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "organophosphorus resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046683

[Term]
id: GO:0008165
name: obsolete pyrethroid resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "pyrethroid resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046684

[Term]
id: GO:0008166
name: obsolete viral replication
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms.
synonym: "viral replication" EXACT []
is_obsolete: true
consider: GO:0019079

[Term]
id: GO:0008167
name: obsolete sigma virus replication
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
synonym: "sigma virus replication" EXACT []
is_obsolete: true
replaced_by: GO:0019079

[Term]
id: GO:0008168
name: methyltransferase activity
namespace: molecular_function
alt_id: GO:0004480
def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "methylase" BROAD []
xref: EC:2.1.1.-
xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3"
xref: Reactome:R-HSA-379387 "COMT transfers Met to DA to form 3MT"
xref: Reactome:R-HSA-379464 "COMT transfers Met to DOPAC to form HVA"
xref: Reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII"
xref: Reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine"
xref: Reactome:R-HSA-9710490 "The GSDME gene promoter is hypermethylated"
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0008169
name: C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008170
name: N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008171
name: O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]
xref: Reactome:R-HSA-5578717 "BCDIN3D dimethylates 5' phosphate of pre-miR-145"
xref: Reactome:R-HSA-5629203 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH"
xref: Reactome:R-HSA-5629218 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1"
xref: Reactome:R-HSA-5629237 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH"
xref: Reactome:R-HSA-6790907 "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008172
name: S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai]
xref: Reactome:R-HSA-209821 "Methylation of N-acetyl-5-HT to form melatonin"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008173
name: RNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]
xref: Reactome:R-HSA-191784 "snRNA Cap hypermethylation"
is_a: GO:0008168 ! methyltransferase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0008174
name: mRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah]
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008175
name: tRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah]
xref: Reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)"
xref: Reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)"
xref: Reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)"
xref: Reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)"
xref: Reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34"
xref: Reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine"
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0008176
name: tRNA (guanine(46)-N7)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine." [RHEA:42708]
synonym: "7-methylguanine transfer ribonucleate methylase activity" BROAD [EC:2.1.1.33]
synonym: "N7-methylguanine methylase activity" BROAD [EC:2.1.1.33]
synonym: "tRNA (guanine(46)-N7-)-methyltransferase activity" EXACT []
synonym: "tRNA (guanine-N7-)-methyltransferase activity" BROAD []
synonym: "tRNA (guanosine(46)-N(7))-methyltransferase activity" EXACT []
synonym: "tRNA (guanosine(46)-N7)-methyltransferase activity" EXACT []
synonym: "tRNA (guanosine(46)-N7-)-methyltransferase activity" EXACT []
synonym: "tRNA guanine 7-methyltransferase activity" BROAD [EC:2.1.1.33]
xref: EC:2.1.1.33
xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46"
xref: RHEA:42708
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0008177
name: succinate dehydrogenase (quinone) activity
namespace: molecular_function
alt_id: GO:0019737
def: "Catalysis of the reaction: a quinone + succinate = a quinol + fumarate." [RHEA:40523]
synonym: "fumarate reductase (menaquinone)" NARROW []
synonym: "succinate dehydrogenase (menaquinone)" NARROW []
synonym: "succinate dehydrogenase (ubiquinone) activity" NARROW []
synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1]
xref: EC:1.3.5.1
xref: KEGG_REACTION:R02164
xref: MetaCyc:RXN-14971
xref: Reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:R-HSA-70994 "SDH complex dehydrogenates succinate"
xref: RHEA:40523
is_a: GO:0000104 ! succinate dehydrogenase activity
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0008179
name: adenylate cyclase binding
namespace: molecular_function
def: "Binding to an adenylate cyclase." [GOC:jl]
synonym: "adenylyl cyclase binding" EXACT []
xref: Reactome:R-HSA-170672 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0008180
name: COP9 signalosome
namespace: cellular_component
def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]
synonym: "COP9 complex" EXACT [GOC:krc]
synonym: "CSN" EXACT []
synonym: "signalosome" BROAD [GOC:krc]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0008181
name: obsolete tumor suppressor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way.
synonym: "tumor suppressor" EXACT []
is_obsolete: true
consider: GO:0051726

[Term]
id: GO:0008184
name: glycogen phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [MetaCyc:GLYCOPHOSPHORYL-RXN]
xref: MetaCyc:GLYCOPHOSPHORYL-RXN
xref: Reactome:R-HSA-453339 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]"
xref: Reactome:R-HSA-453358 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]"
xref: Reactome:R-HSA-71515 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]"
xref: Reactome:R-HSA-71590 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]"
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0008186
name: ATP-dependent activity, acting on RNA
namespace: molecular_function
alt_id: GO:0004010
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl]
synonym: "ATPase activity, acting on RNA" EXACT []
synonym: "ATPase, acting on RNA" EXACT []
synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT []
synonym: "RNA-dependent ATPase activity" EXACT []
xref: Reactome:R-HSA-9770847 "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)"
xref: Reactome:R-HSA-9772351 "Disassembly of the Intron Lariat Spliceosome (new)"
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0008187
name: poly-pyrimidine tract binding
namespace: molecular_function
def: "Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl]
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0008188
name: neuropeptide receptor activity
namespace: molecular_function
def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0008189
name: obsolete apoptosis inhibitor activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "apoptosis inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0043066

[Term]
id: GO:0008190
name: eukaryotic initiation factor 4E binding
namespace: molecular_function
def: "Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732]
synonym: "eIF4E binding" EXACT []
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0008191
name: metalloendopeptidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]
synonym: "metalloprotease inhibitor" NARROW []
synonym: "metalloproteinase inhibitor" NARROW []
is_a: GO:0004866 ! endopeptidase inhibitor activity

[Term]
id: GO:0008192
name: RNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah]
is_a: GO:0070568 ! guanylyltransferase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0008193
name: tRNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461]
xref: EC:2.7.7.79
xref: RHEA:54564
is_a: GO:0008192 ! RNA guanylyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0008194
name: UDP-glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]
xref: Reactome:R-HSA-162730 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP"
is_a: GO:0016757 ! glycosyltransferase activity

[Term]
id: GO:0008195
name: phosphatidate phosphatase activity
namespace: molecular_function
alt_id: GO:0004606
def: "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]
synonym: "3-sn-phosphatidate phosphohydrolase activity" RELATED [EC:3.1.3.4]
synonym: "acid phosphatidyl phosphatase activity" RELATED [EC:3.1.3.4]
synonym: "phosphatic acid phosphatase activity" RELATED [EC:3.1.3.4]
synonym: "phosphatic acid phosphohydrolase activity" RELATED [EC:3.1.3.4]
synonym: "phosphatidate phosphohydrolase activity" EXACT []
synonym: "phosphatidic acid phosphatase activity" RELATED [EC:3.1.3.4]
xref: EC:3.1.3.4
xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN
xref: Reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN"
xref: Reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A"
xref: Reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 556) by PP2A"
xref: Reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1"
xref: Reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A"
xref: Reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol"
xref: Reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA"
xref: Reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate"
xref: RHEA:27429
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0008196
name: vitellogenin receptor activity
namespace: molecular_function
def: "Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis." [GOC:bf, PMID:12429745]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0008197
name: obsolete yolk protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "yolk protein" EXACT []
is_obsolete: true
consider: GO:0005198
consider: GO:0045735

[Term]
id: GO:0008198
name: ferrous iron binding
namespace: molecular_function
def: "Binding to a ferrous iron ion, Fe(II)." [GOC:ai]
is_a: GO:0005506 ! iron ion binding

[Term]
id: GO:0008199
name: ferric iron binding
namespace: molecular_function
def: "Binding to a ferric iron ion, Fe(III)." [GOC:ai]
is_a: GO:0005506 ! iron ion binding

[Term]
id: GO:0008200
name: ion channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of an ion channel." [GOC:mah]
is_a: GO:0016248 ! channel inhibitor activity
is_a: GO:0099106 ! ion channel regulator activity

[Term]
id: GO:0008201
name: heparin binding
namespace: molecular_function
def: "Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
synonym: "heparan sulfate binding" RELATED []
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0008202
name: steroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]
synonym: "steroid metabolism" EXACT []
xref: Wikipedia:Steroid_metabolism
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0008203
name: cholesterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732]
synonym: "cholesterol metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0008204
name: ergosterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732]
synonym: "ergosterol metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0008205
name: ecdysone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732]
synonym: "ecdysone metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0045455 ! ecdysteroid metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0008206
name: bile acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators]
synonym: "bile acid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0008207
name: C21-steroid hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0008208
name: C21-steroid hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone breakdown" EXACT []
synonym: "C21-steroid hormone catabolism" EXACT []
synonym: "C21-steroid hormone degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0008209
name: androgen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732]
synonym: "androgen metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0008210
name: estrogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]
synonym: "estrogen metabolism" EXACT []
synonym: "oestrogen metabolic process" EXACT []
synonym: "oestrogen metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0008211
name: glucocorticoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732]
synonym: "glucocorticoid metabolism" EXACT []
synonym: "glucocorticosteroid metabolic process" EXACT []
synonym: "glucocorticosteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0008212
name: mineralocorticoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732]
synonym: "mineralocorticoid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0008213
name: protein alkylation
namespace: biological_process
def: "The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom." [GOC:ma]
subset: gocheck_obsoletion_candidate
subset: goslim_yeast
synonym: "protein amino acid alkylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0008214
name: protein dealkylation
namespace: biological_process
def: "The removal of an alkyl group from a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid dealkylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0008215
name: spermine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:curators]
synonym: "spermine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0008216
name: spermidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
synonym: "spermidine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0008217
name: regulation of blood pressure
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure homeostasis" RELATED []
synonym: "blood pressure regulation" EXACT []
synonym: "control of blood pressure" RELATED []
xref: Wikipedia:Blood_pressure#Regulation
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0008218
name: bioluminescence
namespace: biological_process
def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_metagenomics
xref: Wikipedia:Bioluminescence
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0008219
name: cell death
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]
comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.
subset: gocheck_do_not_annotate
synonym: "accidental cell death" RELATED []
synonym: "necrosis" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0008220
name: obsolete necrosis
namespace: biological_process
def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma]
comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created.
synonym: "necrosis" EXACT []
is_obsolete: true
consider: GO:0001906
consider: GO:0008219
consider: GO:0012501
consider: GO:0019835

[Term]
id: GO:0008222
name: obsolete tumor antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "tumor antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0008224
name: obsolete Gram-positive antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "Gram-positive antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0050830

[Term]
id: GO:0008225
name: obsolete Gram-negative antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "Gram-negative antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0050829

[Term]
id: GO:0008226
name: tyramine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [GOC:curators]
is_a: GO:0008227 ! G protein-coupled amine receptor activity

[Term]
id: GO:0008227
name: G protein-coupled amine receptor activity
namespace: molecular_function
def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "biogenic amine receptor" NARROW []
synonym: "G-protein coupled amine receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0008228
name: opsonization
namespace: biological_process
def: "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149]
xref: Wikipedia:Opsonin
is_a: GO:0002252 ! immune effector process
relationship: positively_regulates GO:0006910 ! phagocytosis, recognition

[Term]
id: GO:0008229
name: obsolete opsonin activity
namespace: molecular_function
def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "opsonin activity" EXACT []
is_obsolete: true
consider: GO:0003823

[Term]
id: GO:0008230
name: ecdysone receptor holocomplex
namespace: cellular_component
def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0008231
name: repressor ecdysone receptor complex
namespace: cellular_component
def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333]
synonym: "repressor ecdysone receptor holocomplex" RELATED []
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008232
name: activator ecdysone receptor complex
namespace: cellular_component
def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333]
synonym: "activator ecdysone receptor holocomplex" RELATED []
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008233
name: peptidase activity
namespace: molecular_function
alt_id: GO:0070010
alt_id: GO:0070011
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
synonym: "hydrolase, acting on peptide bonds" EXACT []
synonym: "peptidase activity, acting on D-amino acid peptides" NARROW []
synonym: "peptidase activity, acting on L-amino acid peptides" NARROW []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" EXACT []
synonym: "proteinase activity" NARROW []
xref: EC:3.4.-.-
xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6"
xref: Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl"
xref: Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl"
xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA"
xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs"
xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion"
xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT"
xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB"
xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)"
xref: Reactome:R-HSA-5655483 "USP1 autocleavage"
xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB"
xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC"
xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)"
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008234
name: cysteine-type peptidase activity
namespace: molecular_function
alt_id: GO:0004220
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
synonym: "cysteine protease activity" NARROW []
synonym: "thiol protease activity" NARROW []
xref: Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
xref: Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)"
xref: Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin"
xref: Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA"
xref: Reactome:R-HSA-9757951 "CASP8 cleaves N4BP1 at D424, D490"
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0008235
name: metalloexopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]
is_a: GO:0008237 ! metallopeptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008236
name: serine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
synonym: "serine protease activity" NARROW []
xref: Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin"
xref: Reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
xref: Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:RCbl"
xref: Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)"
xref: Reactome:R-HSA-9839072 "HTRA2 degrades APP (Amyloid-beta precursor protein)"
xref: Reactome:R-HSA-9839110 "HTRA2 degrades NDUFA13 (GRIM-19)"
is_a: GO:0008233 ! peptidase activity
is_a: GO:0017171 ! serine hydrolase activity

[Term]
id: GO:0008237
name: metallopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
synonym: "metalloprotease activity" NARROW [GOC:mah]
synonym: "metalloproteinase activity" NARROW [GOC:mah]
xref: Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2"
xref: Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1"
xref: Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain"
xref: Reactome:R-HSA-2022368 "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42)"
xref: Reactome:R-HSA-2022393 "ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)"
xref: Reactome:R-HSA-2022396 "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43)"
xref: Reactome:R-HSA-2022399 "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)"
xref: Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants"
xref: Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding"
xref: Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1"
xref: Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding"
xref: Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs"
xref: Reactome:R-HSA-5211340 "Anthrax lef cleaves target cell MAP2K1 (MEK1)"
xref: Reactome:R-HSA-5211356 "Anthrax lef cleaves target cell MAP2K2 (MEK2)"
xref: Reactome:R-HSA-5211387 "Anthrax lef cleaves target cell MAP2K7 (MEK7)"
xref: Reactome:R-HSA-5211391 "Anthrax lef cleaves target cell MAP2K4 (MEK4)"
xref: Reactome:R-HSA-5211400 "Anthrax lef cleaves target cell MAP2K3 (MEK3)"
xref: Reactome:R-HSA-5211405 "Anthrax lef cleaves target cell MAP2K6 (MEK6)"
xref: Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)"
xref: Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3"
xref: Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4"
xref: Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163"
xref: Reactome:R-HSA-9759522 "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform"
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0008238
name: exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]
synonym: "exoprotease activity" NARROW []
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0008239
name: dipeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008240
name: tripeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]
xref: EC:3.4.14.10
xref: MetaCyc:3.4.14.10-RXN
is_a: GO:0070008 ! serine-type exopeptidase activity

[Term]
id: GO:0008241
name: peptidyl-dipeptidase activity
namespace: molecular_function
def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [EC:3.4.15.-, GOC:mb]
xref: EC:3.4.15.-
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008242
name: omega peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]
synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED []
xref: EC:3.4.19.-
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0008243
name: obsolete plasminogen activator activity
namespace: molecular_function
alt_id: GO:0004296
alt_id: GO:0004297
def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "abbokinase activity" RELATED []
synonym: "cellular plasminogen activator activity" NARROW []
synonym: "double-chain urokinase-type plasminogen activator" RELATED []
synonym: "plasminogen activator activity" EXACT []
synonym: "plasminogen activator, tissue-type" RELATED []
synonym: "t-PA" RELATED []
synonym: "t-plasminogen activator activity" NARROW []
synonym: "tissue plasminogen activator activity" NARROW []
synonym: "tissue-type plasminogen activator activity" RELATED []
synonym: "tPA activity" NARROW []
synonym: "two-chain urokinase-type plasminogen activator" RELATED []
synonym: "u-PA" RELATED []
synonym: "u-plasminogen activator activity" NARROW []
synonym: "uPA" RELATED []
synonym: "urinary esterase A" RELATED []
synonym: "urinary plasminogen activator activity" NARROW []
synonym: "urokinase activity" RELATED []
synonym: "urokinase plasminogen activator" RELATED []
synonym: "urokinase-type plasminogen activator" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008245
name: obsolete lysosomal membrane hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "lysosomal membrane hydrogen-transporting ATPase" EXACT []
synonym: "V-ATPase" RELATED []
is_obsolete: true
consider: GO:0046611

[Term]
id: GO:0008246
name: obsolete electron transfer flavoprotein
namespace: molecular_function
def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "electron transfer flavoprotein" EXACT []
synonym: "ETF" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0008247
name: 1-alkyl-2-acetylglycerophosphocholine esterase complex
namespace: cellular_component
def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206]
comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'.
synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT []
synonym: "platelet-activating factor acetylhydrolase complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0008248
name: obsolete pre-mRNA splicing factor activity
namespace: molecular_function
def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl]
comment: This term was made obsolete because it describes a biological process.
synonym: "pre-mRNA splicing factor activity" EXACT []
is_obsolete: true
consider: GO:0008380

[Term]
id: GO:0008250
name: oligosaccharyltransferase complex
namespace: cellular_component
def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. The complex includes at least eight non-identical subunits. Different forms of the complex containing distinct subunits have been detected in mammals." [PMID:15835887, PMID:31810196, PMID:32316603]
synonym: "oligosaccharyl transferase complex" EXACT []
synonym: "OST complex" EXACT []
synonym: "OSTCI" NARROW []
synonym: "OSTCII" NARROW []
synonym: "OSTCIII" NARROW []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0008251
name: tRNA-specific adenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]
synonym: "tRNA-adenosine deaminase activity" EXACT []
xref: Reactome:R-HSA-6782311 "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs"
xref: Reactome:R-HSA-6782336 "ADAT1 deaminates adenosine-37 in tRNA(Ala)"
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008252
name: nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [RHEA:22140]
synonym: "acid nucleotidase activity" RELATED []
synonym: "deoxyinosine-activated nucleotidase (DIAN)" RELATED []
synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" RELATED []
synonym: "NSP I" RELATED []
synonym: "NSP II" RELATED []
synonym: "nucleotide phosphohydrolase activity" RELATED []
synonym: "nucleotide-specific phosphatase activity" RELATED []
xref: RHEA:22140
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008253
name: 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]
synonym: "5' nucleotidase activity" EXACT []
synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5]
synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5]
synonym: "5'-AMPase" NARROW [EC:3.1.3.5]
synonym: "5'-mononucleotidase activity" RELATED [EC:3.1.3.5]
synonym: "5'-ribonucleotide phosphohydrolase activity" RELATED [EC:3.1.3.5]
synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5]
synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5]
synonym: "AMP phosphatase" NARROW [EC:3.1.3.5]
synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5]
synonym: "AMPase" NARROW [EC:3.1.3.5]
synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5]
synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5]
synonym: "UMPase" NARROW [EC:3.1.3.5]
synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5]
xref: EC:3.1.3.5
xref: MetaCyc:5-NUCLEOTID-RXN
xref: Reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP"
xref: Reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]"
xref: Reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)"
xref: Reactome:R-HSA-109387 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)"
xref: Reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]"
xref: Reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)"
xref: Reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)"
xref: Reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]"
xref: Reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]"
xref: Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG"
xref: Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)"
xref: Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+"
xref: Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN"
xref: Reactome:R-HSA-9755078 "NT5C2 tetramer dephosphorylates RBV-MP"
xref: RHEA:12484
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008254
name: 3'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6]
synonym: "3' nucleotidase activity" EXACT []
synonym: "3'-mononucleotidase activity" RELATED [EC:3.1.3.6]
synonym: "3'-phosphatase activity" RELATED [EC:3.1.3.6]
synonym: "3'-ribonucleotidase activity" RELATED [EC:3.1.3.6]
synonym: "3'-ribonucleotide phosphohydrolase activity" RELATED [EC:3.1.3.6]
xref: EC:3.1.3.6
xref: MetaCyc:3-NUCLEOTID-RXN
xref: RHEA:10144
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008255
name: ecdysis-triggering hormone activity
namespace: molecular_function
def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0008256
name: protein histidine pros-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1]
synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" RELATED [EC:2.7.13.1]
synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1]
synonym: "protein-histidine pros-kinase activity" EXACT []
xref: EC:2.7.13.1
xref: MetaCyc:2.7.13.1-RXN
xref: RHEA:22720
is_a: GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0008257
name: protein histidine tele-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2]
synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" RELATED [EC:2.7.13.2]
synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" RELATED [EC:2.7.13.2]
synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2]
xref: EC:2.7.13.2
xref: MetaCyc:2.7.13.2-RXN
xref: RHEA:11860
is_a: GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0008258
name: head involution
namespace: biological_process
def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:0879694238]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0008259
name: obsolete transforming growth factor beta ligand binding to type I receptor
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function.
synonym: "TGF-beta ligand binding to type I receptor" EXACT []
synonym: "TGFbeta ligand binding to type I receptor" EXACT []
synonym: "transforming growth factor beta ligand binding to type I receptor" EXACT []
is_obsolete: true
consider: GO:0005025
consider: GO:0005160
consider: GO:0050431

[Term]
id: GO:0008260
name: succinyl-CoA:3-oxo-acid CoA-transferase activity
namespace: molecular_function
alt_id: GO:0106424
def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [GOC:vw, PMID:10964512, PMID:8844009, RHEA:24564]
synonym: "3-oxo-CoA transferase activity" RELATED [EC:2.8.3.5]
synonym: "3-oxoacid CoA dehydrogenase activity" RELATED [EC:2.8.3.5]
synonym: "3-oxoacid CoA-transferase activity" EXACT []
synonym: "3-oxoacid coenzyme A-transferase activity" RELATED [EC:2.8.3.5]
synonym: "acetoacetate succinyl-CoA transferase activity" RELATED [EC:2.8.3.5]
synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" RELATED [EC:2.8.3.5]
synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" RELATED [EC:2.8.3.5]
synonym: "succinyl-CoA 3-ketoacid-CoA transferase activity" RELATED []
synonym: "succinyl-CoA transferase activity" RELATED [EC:2.8.3.5]
synonym: "Succinyl-CoA:3-ketoacid-CoA transferase" EXACT []
xref: EC:2.8.3.5
xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN
xref: Reactome:R-HSA-74177 "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA"
xref: RHEA:24564
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008261
name: allatostatin receptor activity
namespace: molecular_function
def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0008263
name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT []
is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0008265
name: molybdenum cofactor sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin." [PMID:11549764, RHEA:42636]
synonym: "Mo-molybdopterin cofactor sulfurase activity" EXACT []
synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT []
synonym: "molybdopterin cofactor sulfurase activity" EXACT []
synonym: "molybdopterin synthase sulfurylase activity" EXACT []
xref: EC:2.8.1.9
xref: MetaCyc:RXN-8351
xref: Reactome:R-HSA-947499 "Exchange of oxygen with sulfur in MoCo"
xref: RHEA:42636
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0008266
name: poly(U) RNA binding
namespace: molecular_function
def: "Binding to a sequence of uracil residues in an RNA molecule." [GOC:mah]
synonym: "poly(U) binding" EXACT [GOC:mah]
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0008267
name: poly-glutamine tract binding
namespace: molecular_function
def: "Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008268
name: obsolete receptor signaling protein tyrosine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein tyrosine kinase signaling protein activity" EXACT []
synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0035556

[Term]
id: GO:0008269
name: JAK pathway signal transduction adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0035591 ! signaling adaptor activity

[Term]
id: GO:0008270
name: zinc ion binding
namespace: molecular_function
def: "Binding to a zinc ion (Zn)." [GOC:ai]
synonym: "zinc binding" EXACT []
synonym: "Zn binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0008271
name: secondary active sulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
synonym: "secondary active sulphate transmembrane transporter activity" EXACT []
synonym: "sulfate porter activity" RELATED []
synonym: "sulphate porter activity" EXACT []
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008272
name: obsolete sulfate transport
namespace: biological_process
alt_id: GO:0006870
def: "OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
comment: The reason for obsoletion is that this term is equivalent to sulphate transmembrane transport.
synonym: "sulphate transport" EXACT []
is_obsolete: true
replaced_by: GO:1902358

[Term]
id: GO:0008273
name: calcium, potassium:sodium antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]
synonym: "potassium-dependent sodium/calcium exchanger" RELATED []
xref: Reactome:R-HSA-2514891 "SLC24A1 exchanges 4Na+ for Ca2+, K+"
xref: Reactome:R-HSA-425678 "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+"
xref: Reactome:R-HSA-5625841 "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+"
xref: Reactome:R-HSA-5626270 "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+"
xref: Reactome:R-HSA-5626316 "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+"
xref: Reactome:R-HSA-5626356 "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+"
xref: RHEA:69967
is_a: GO:0005432 ! calcium:sodium antiporter activity
is_a: GO:0022821 ! solute:potassium antiporter activity

[Term]
id: GO:0008275
name: gamma-tubulin small complex
namespace: cellular_component
alt_id: GO:0000927
alt_id: GO:0000928
alt_id: GO:0061495
def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075]
synonym: "gamma-tubulin small complex, centrosomal" NARROW []
synonym: "gamma-tubulin small complex, mitotic spindle pole body" NARROW []
synonym: "gamma-tubulin small complex, spindle pole body" NARROW []
synonym: "gammaTuSC" EXACT []
synonym: "Tub4 complex" NARROW []
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0008276
name: protein methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]
synonym: "protein methylase activity" EXACT []
xref: Reactome:R-HSA-9632182 "PRMT1 methylates ESRs"
is_a: GO:0008168 ! methyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008277
name: regulation of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]
synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of GPCR protein signaling pathway" EXACT []
synonym: "regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0008278
name: cohesin complex
namespace: cellular_component
alt_id: GO:0000798
alt_id: GO:0008279
alt_id: GO:0008280
alt_id: GO:0043222
def: "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]
subset: goslim_pir
synonym: "14S cohesin" NARROW []
synonym: "9S cohesin" NARROW []
synonym: "cohesin core heterodimer" RELATED []
synonym: "nuclear cohesin complex" RELATED []
synonym: "SMC complex" RELATED []
synonym: "SMC/kleisin ring complex" EXACT []
synonym: "Smc1-Smc3 complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0008281
name: sulfonylurea receptor activity
namespace: molecular_function
def: "Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'.
synonym: "sulphonylurea receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0008282
name: inward rectifying potassium channel
namespace: cellular_component
def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity." [GOC:bhm, PMID:16308567, PMID:16956886]
synonym: "ATP-sensitive potassium channel complex" EXACT []
synonym: "inward rectifying K+ channel" EXACT []
synonym: "KCNJ11-SUR complex" RELATED []
synonym: "KCNJ11-SURx complex" RELATED []
synonym: "KCNJ8-SUR complex" RELATED []
synonym: "KCNJ8-SURx complex" RELATED []
synonym: "Kir6-SUR complex" RELATED []
synonym: "Kir6.1-SUR complex" RELATED []
synonym: "Kir6.1-SURx complex" RELATED []
synonym: "Kir6.2-SUR complex" RELATED []
synonym: "Kir6.2-SURx complex" RELATED []
synonym: "Kir6.x complex" RELATED []
synonym: "Kir6.x-SURx complex" RELATED []
is_a: GO:0034705 ! potassium channel complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0008283
name: cell population proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "cell proliferation" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0008284
name: positive regulation of cell population proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "activation of cell proliferation" NARROW []
synonym: "positive regulation of cell proliferation" RELATED []
synonym: "stimulation of cell proliferation" NARROW []
synonym: "up regulation of cell proliferation" EXACT []
synonym: "up-regulation of cell proliferation" EXACT []
synonym: "upregulation of cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0008283 ! cell population proliferation

[Term]
id: GO:0008285
name: negative regulation of cell population proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "down regulation of cell proliferation" EXACT []
synonym: "down-regulation of cell proliferation" EXACT []
synonym: "downregulation of cell proliferation" EXACT []
synonym: "inhibition of cell proliferation" NARROW []
synonym: "negative regulation of cell proliferation" RELATED []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0008283 ! cell population proliferation

[Term]
id: GO:0008286
name: insulin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
synonym: "daf-2 receptor signaling pathway" NARROW []
synonym: "insulin receptor signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0032869 ! cellular response to insulin stimulus

[Term]
id: GO:0008287
name: protein serine/threonine phosphatase complex
namespace: cellular_component
def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]
subset: goslim_pir
is_a: GO:1903293 ! phosphatase complex

[Term]
id: GO:0008288
name: boss receptor activity
namespace: molecular_function
def: "Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:jl, GOC:signaling]
synonym: "sevenless receptor activity" RELATED []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0008289
name: lipid binding
namespace: molecular_function
def: "Binding to a lipid." [GOC:ai]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
is_a: GO:0005488 ! binding

[Term]
id: GO:0008290
name: F-actin capping protein complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0008291
name: acetylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752]
synonym: "acetylcholine metabolism" EXACT []
is_a: GO:1900619 ! acetate ester metabolic process

[Term]
id: GO:0008292
name: acetylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine anabolism" EXACT []
synonym: "acetylcholine biosynthesis" EXACT []
synonym: "acetylcholine formation" EXACT []
synonym: "acetylcholine synthesis" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:1900620 ! acetate ester biosynthetic process

[Term]
id: GO:0008293
name: torso signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
synonym: "torso signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0008294
name: calcium- and calmodulin-responsive adenylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [GOC:mah, PMID:1739965]
synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT []
synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT []
xref: Reactome:R-HSA-111930 "Adenylate cyclase produces cAMP"
xref: Reactome:R-HSA-442715 "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP"
is_a: GO:0004016 ! adenylate cyclase activity

[Term]
id: GO:0008295
name: spermidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]
synonym: "spermidine anabolism" EXACT []
synonym: "spermidine biosynthesis" EXACT []
synonym: "spermidine formation" EXACT []
synonym: "spermidine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0008296
name: 3'-5'-DNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]
synonym: "3'-5' exodeoxyribonuclease activity" EXACT []
synonym: "3'-5'-exodeoxyribonuclease activity" EXACT []
xref: Reactome:R-HSA-9023943 "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end"
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016895 ! DNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008297
name: single-stranded DNA exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah]
synonym: "single-stranded DNA specific exodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific exodeoxyribonuclease activity" RELATED [GOC:mah]
is_a: GO:0016895 ! DNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008298
name: intracellular mRNA localization
namespace: biological_process
def: "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of intracellular RNA localization" EXACT []
synonym: "intracellular mRNA localisation" EXACT [GOC:mah]
synonym: "intracellular mRNA positioning" NARROW []
synonym: "mRNA localization, intracellular" EXACT []
synonym: "mRNA positioning, intracellular" NARROW []
is_a: GO:0006403 ! RNA localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0008299
name: isoprenoid biosynthetic process
namespace: biological_process
alt_id: GO:0009241
def: "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
synonym: "isoprenoid anabolism" EXACT []
synonym: "isoprenoid biosynthesis" EXACT []
synonym: "isoprenoid formation" EXACT []
synonym: "isoprenoid synthesis" EXACT []
synonym: "polyisoprenoid anabolism" NARROW []
synonym: "polyisoprenoid biosynthesis" NARROW []
synonym: "polyisoprenoid biosynthetic process" NARROW []
synonym: "polyisoprenoid formation" NARROW []
synonym: "polyisoprenoid synthesis" NARROW []
synonym: "polyterpene biosynthesis" NARROW []
synonym: "polyterpene biosynthetic process" NARROW []
xref: MetaCyc:POLYISOPRENSYN-PWY
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0008300
name: isoprenoid catabolic process
namespace: biological_process
alt_id: GO:0016097
def: "The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
synonym: "isoprenoid breakdown" EXACT []
synonym: "isoprenoid catabolism" EXACT []
synonym: "isoprenoid degradation" EXACT []
synonym: "polyisoprenoid breakdown" NARROW []
synonym: "polyisoprenoid catabolic process" NARROW []
synonym: "polyisoprenoid catabolism" NARROW []
synonym: "polyisoprenoid degradation" NARROW []
synonym: "polyterpene catabolic process" NARROW []
synonym: "polyterpene catabolism" NARROW []
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0016042 ! lipid catabolic process

[Term]
id: GO:0008301
name: DNA binding, bending
namespace: molecular_function
def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
synonym: "DNA bending activity" EXACT []
synonym: "DNA bending involving DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0008302
name: female germline ring canal formation, actin assembly
namespace: biological_process
def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238]
synonym: "nurse cell ring canal formation, actin assembly" NARROW []
synonym: "ovarian ring canal formation, actin assembly" NARROW []
synonym: "ring canal formation, actin assembly" BROAD []
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0007301 ! female germline ring canal formation

[Term]
id: GO:0008303
name: caspase complex
namespace: cellular_component
def: "A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes." [GOC:cna, GOC:mtg_apoptosis, PMID:15569692]
comment: Note that this term was reinstated from obsolete.
synonym: "cysteine-type endopeptidase complex" EXACT [GOC:pr]
is_a: GO:1905369 ! endopeptidase complex

[Term]
id: GO:0008304
name: obsolete eukaryotic translation initiation factor 4 complex
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "eIF-4" EXACT []
synonym: "eukaryotic translation initiation factor 4 complex" EXACT []
is_obsolete: true
replaced_by: GO:0016281

[Term]
id: GO:0008305
name: integrin complex
namespace: cellular_component
def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]
synonym: "laminin receptor protein" RELATED []
is_a: GO:0098636 ! protein complex involved in cell adhesion
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0008306
name: associative learning
namespace: biological_process
def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
synonym: "classical conditioning" EXACT []
synonym: "conditional learning" EXACT []
synonym: "conditional response" EXACT []
synonym: "Pavlovian conditioning" EXACT []
xref: Wikipedia:Learning#Associative_learning
is_a: GO:0007612 ! learning

[Term]
id: GO:0008307
name: structural constituent of muscle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008308
name: voltage-gated monoatomic anion channel activity
namespace: molecular_function
alt_id: GO:0022844
def: "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729]
synonym: "voltage-dependent ion-selective channel activity" RELATED []
synonym: "voltage-gated anion channel activity" BROAD []
synonym: "voltage-gated ion-selective channel activity" RELATED []
xref: Reactome:R-HSA-9012374 "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space"
is_a: GO:0005244 ! voltage-gated monoatomic ion channel activity
is_a: GO:0005253 ! monoatomic anion channel activity

[Term]
id: GO:0008309
name: double-stranded DNA exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah]
synonym: "double-stranded DNA specific exodeoxyribonuclease activity" RELATED []
is_a: GO:0016895 ! DNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008310
name: single-stranded DNA 3'-5' DNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]
synonym: "exonuclease I activity" NARROW []
synonym: "single-stranded DNA 3'-5' exodeoxyribonuclease activity" EXACT []
synonym: "single-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" RELATED [GOC:mah]
xref: EC:3.1.11.1
xref: MetaCyc:3.1.11.1-RXN
is_a: GO:0008296 ! 3'-5'-DNA exonuclease activity
is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity

[Term]
id: GO:0008311
name: double-stranded DNA 3'-5' DNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]
synonym: "double-stranded DNA 3'-5' exodeoxyribonuclease activity" EXACT []
synonym: "double-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED []
synonym: "exonuclease III activity" NARROW []
synonym: "exoribonuclease III activity" NARROW []
xref: EC:3.1.11.2
xref: MetaCyc:3.1.11.2-RXN
is_a: GO:0008296 ! 3'-5'-DNA exonuclease activity
is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity

[Term]
id: GO:0008312
name: 7S RNA binding
namespace: molecular_function
def: "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0008313
name: obsolete gurken-activated receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf]
comment: This term was obsoleted because it represents a receptor by its ligand.
synonym: "gurken receptor activity" EXACT [GOC:bf, GOC:signaling]
is_obsolete: true

[Term]
id: GO:0008314
name: obsolete gurken signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to a ligand Gurken." [GOC:bf, PMID:23972992]
comment: The reason for obsoletion is that this term represents a gene product.
synonym: "gurken receptor signaling pathway" EXACT []
synonym: "gurken receptor signalling pathway" EXACT []
synonym: "gurken-activated signaling pathway" RELATED [GOC:signaling]
synonym: "signaling by Gurken" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0008315
name: G2/MI transition of meiotic cell cycle
namespace: biological_process
def: "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I." [PMID:15084480]
synonym: "meiotic cell cycle G2/MI phase transition" EXACT []
synonym: "meiotic G2/MI phase transition" EXACT []
synonym: "meiotic G2/MI transition" EXACT []
is_a: GO:0044771 ! meiotic cell cycle phase transition
is_a: GO:0044839 ! cell cycle G2/M phase transition
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0008316
name: structural constituent of vitelline membrane
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008317
name: obsolete gurken receptor binding
namespace: molecular_function
def: "OBSOLETE. Binding to a gurken growth factor receptor." [GOC:ai]
comment: The reason for obsoletion is that this term represents a gene product.
synonym: "gurken receptor ligand" NARROW []
is_obsolete: true

[Term]
id: GO:0008318
name: protein prenyltransferase activity
namespace: molecular_function
alt_id: GO:0008244
def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]
is_a: GO:0004659 ! prenyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008319
name: obsolete prenyl protein specific endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "prenyl protein specific endopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008320
name: protein transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015266
alt_id: GO:0015463
def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl]
synonym: "protein channel activity" RELATED []
xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space"
xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix"
xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex"
xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane"
xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria"
xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol"
xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen"
xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol"
xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane"
xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol"
xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation"
xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation"
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:0140318 ! protein transporter activity

[Term]
id: GO:0008322
name: obsolete Pro-X carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "Pro-X carboxypeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0030536

[Term]
id: GO:0008324
name: monoatomic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
synonym: "cation transmembrane transporter activity" BROAD []
synonym: "transmembrane cation transporter activity" EXACT []
is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity

[Term]
id: GO:0008327
name: methyl-CpG binding
namespace: molecular_function
def: "Binding to a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232]
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0008328
name: ionotropic glutamate receptor complex
namespace: cellular_component
def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [PMID:20716669, PMID:34753794]
is_a: GO:0034702 ! monoatomic ion channel complex
is_a: GO:0098878 ! neurotransmitter receptor complex

[Term]
id: GO:0008330
name: protein tyrosine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0008331
name: high voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
synonym: "high voltage gated calcium channel activity" EXACT []
synonym: "high voltage-dependent calcium channel activity" EXACT []
synonym: "L-type calcium channel" RELATED []
synonym: "N-type calcium channel" RELATED []
synonym: "P-type calcium channel" RELATED []
synonym: "Q-type calcium channel" RELATED []
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0008332
name: low voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
synonym: "low voltage gated calcium channel activity" EXACT []
synonym: "low voltage-dependent calcium channel activity" EXACT []
synonym: "T-type calcium channel" RELATED []
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0008333
name: endosome to lysosome transport
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0008334
name: histone mRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393]
comment: In higher Eukaryotes, histone mRNAs (stem-loop containing) are non-polyadenylated and thus have a different form of 3'-end regulation to other mRNAs. In lower Eukaryotes, the 3'-ends of histone mRNAs are polyadenylated.
synonym: "histone mRNA metabolism" EXACT []
synonym: "stem-loop-containing histone mRNA 3'-end processing" NARROW [GOC:krc, GOC:mah, PMID:17855393]
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0008335
name: female germline ring canal stabilization
namespace: biological_process
def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators]
synonym: "nurse cell ring canal stabilization" NARROW []
synonym: "ovarian ring canal stabilization" NARROW []
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0008336
name: gamma-butyrobetaine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate." [EC:1.14.11.1, RHEA:24028]
synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.1]
synonym: "alpha-butyrobetaine hydroxylase activity" RELATED [EC:1.14.11.1]
synonym: "butyrobetaine hydroxylase activity" RELATED [EC:1.14.11.1]
synonym: "g-butyrobetaine dioxygenase activity" EXACT []
synonym: "gamma-BBH activity" RELATED [EC:1.14.11.1]
synonym: "gamma-butyrobetaine hydroxylase activity" RELATED [EC:1.14.11.1]
synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT []
xref: EC:1.14.11.1
xref: KEGG_REACTION:R02397
xref: MetaCyc:1.14.11.1-RXN
xref: Reactome:R-HSA-71261 "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA"
xref: RHEA:24028
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0008337
name: obsolete selectin
namespace: molecular_function
def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653]
comment: This term was made obsolete because it describes a class of gene products.
synonym: "selectin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0007155
consider: GO:0030246
consider: GO:0050839

[Term]
id: GO:0008340
name: determination of adult lifespan
namespace: biological_process
def: "The pathways that regulate the duration of the adult phase of the life-cycle of an animal." [PMID:25561524, PMID:273723695, PMID:3424805]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0008341
name: obsolete response to cocaine (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "response to cocaine (sensu Insecta)" EXACT []
is_obsolete: true
consider: GO:0048148

[Term]
id: GO:0008342
name: obsolete larval feeding behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jid, GOC:mah]
comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
synonym: "larval feeding behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0030536

[Term]
id: GO:0008343
name: adult feeding behavior
namespace: biological_process
def: "Feeding behavior in a fully developed and mature organism." [GOC:mah]
comment: See also the biological process term 'feeding behavior ; GO:0007631'.
synonym: "adult feeding behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0030534 ! adult behavior

[Term]
id: GO:0008344
name: adult locomotory behavior
namespace: biological_process
def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai]
comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
synonym: "adult locomotory behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0030534 ! adult behavior

[Term]
id: GO:0008345
name: larval locomotory behavior
namespace: biological_process
def: "Locomotory behavior in a larval (immature) organism." [GOC:ai]
comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
synonym: "larval locomotory behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0030537 ! larval behavior

[Term]
id: GO:0008346
name: larval walking behavior
namespace: biological_process
def: "The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators, GOC:pr]
synonym: "larval walking behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior
is_a: GO:0090659 ! walking behavior

[Term]
id: GO:0008347
name: glial cell migration
namespace: biological_process
alt_id: GO:0043359
def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
synonym: "glia cell migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0008348
name: negative regulation of antimicrobial humoral response
namespace: biological_process
alt_id: GO:0042154
alt_id: GO:0042155
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators]
synonym: "attenuation of antimicrobial humoral response" EXACT []
synonym: "down regulation of antimicrobial humoral response" EXACT []
synonym: "down-regulation of antimicrobial humoral response" EXACT []
synonym: "downregulation of antimicrobial humoral response" EXACT []
synonym: "inhibition of antimicrobial humoral response" NARROW []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0008349
name: MAP kinase kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]
synonym: "MAP4K activity" EXACT [PMID:20811974]
synonym: "MAPKKKK" EXACT []
xref: Reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex"
xref: Reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3"
xref: Reactome:R-HSA-9645442 "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0008350
name: obsolete kinetochore motor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes cellular component information.
synonym: "kinetochore motor activity" EXACT []
is_obsolete: true
consider: GO:0000776
consider: GO:0003777

[Term]
id: GO:0008351
name: obsolete microtubule severing activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
synonym: "microtubule severing activity" EXACT []
is_obsolete: true
consider: GO:0008017
consider: GO:0051013

[Term]
id: GO:0008352
name: katanin complex
namespace: cellular_component
def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'.
is_a: GO:0005875 ! microtubule associated complex
relationship: part_of GO:0005815 ! microtubule organizing center

[Term]
id: GO:0008353
name: RNA polymerase II CTD heptapeptide repeat kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II." [EC:2.7.11.23, GOC:mah, PMID:28248323]
synonym: "[RNA-polymerase]-subunit kinase activity" BROAD []
synonym: "CTD kinase activity" RELATED [EC:2.7.11.23]
synonym: "RNA polymerase II carboxy-terminal domain kinase activity" EXACT []
synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23]
synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23]
xref: EC:2.7.11.23
xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN
xref: Reactome:R-HSA-167191 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex"
xref: Reactome:R-HSA-170704 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex"
xref: Reactome:R-HSA-170706 "Phosphorylation of  NEFL by the P-TEFb(Cyclin T1:Cdk9) complex"
xref: RHEA:10216
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140994 ! RNA polymerase II CTD heptapeptide repeat modifying activity

[Term]
id: GO:0008354
name: germ cell migration
namespace: biological_process
def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
synonym: "germ-cell migration" EXACT []
synonym: "pole cell migration" NARROW []
synonym: "primordial germ cell migration" RELATED []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0008355
name: olfactory learning
namespace: biological_process
def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
is_a: GO:0008306 ! associative learning
is_a: GO:0042048 ! olfactory behavior

[Term]
id: GO:0008356
name: asymmetric cell division
namespace: biological_process
def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
synonym: "asymmetric cytokinesis" RELATED []
synonym: "asymmetrical cell division" EXACT []
synonym: "asymmetrical cytokinesis" RELATED []
xref: Wikipedia:Asymmetric_cell_division
is_a: GO:0051301 ! cell division

[Term]
id: GO:0008358
name: maternal determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo

[Term]
id: GO:0008359
name: regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb]
synonym: "regulation of bicoid mRNA localisation" EXACT [GOC:mah]
is_a: GO:1904580 ! regulation of intracellular mRNA localization
relationship: regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0008360
name: regulation of cell shape
namespace: biological_process
alt_id: GO:0045788
alt_id: GO:0045789
def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0008361
name: regulation of cell size
namespace: biological_process
def: "Any process that modulates the size of a cell." [GOC:go_curators]
synonym: "cell size control" EXACT []
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0008362
name: chitin-based embryonic cuticle biosynthetic process
namespace: biological_process
def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
synonym: "embryonic cuticle anabolism" BROAD []
synonym: "embryonic cuticle biosynthetic process" BROAD []
synonym: "embryonic cuticle formation" BROAD []
synonym: "embryonic cuticle synthesis" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development

[Term]
id: GO:0008363
name: larval chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "larval cuticle anabolism" BROAD []
synonym: "larval cuticle biosynthetic process" BROAD []
synonym: "larval cuticle formation" BROAD []
synonym: "larval cuticle synthesis" BROAD []
is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0008364
name: pupal chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "pupal cuticle anabolism" BROAD []
synonym: "pupal cuticle formation" BROAD []
synonym: "pupal cuticle synthesis" BROAD []
is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle
relationship: part_of GO:0035209 ! pupal development

[Term]
id: GO:0008365
name: adult chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "adult chitin-based cuticle anabolism" EXACT []
synonym: "adult chitin-based cuticle biosynthetic process" EXACT []
synonym: "adult chitin-based cuticle formation" EXACT []
synonym: "adult chitin-based cuticle synthesis" EXACT []
synonym: "adult cuticle anabolism" BROAD []
synonym: "adult cuticle biosynthetic process" BROAD []
synonym: "adult cuticle formation" BROAD []
synonym: "adult cuticle synthesis" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development

[Term]
id: GO:0008366
name: axon ensheathment
namespace: biological_process
alt_id: GO:0042553
def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
synonym: "cellular axon ensheathment" EXACT []
synonym: "cellular nerve ensheathment" RELATED []
synonym: "nerve ensheathment" RELATED []
is_a: GO:0007272 ! ensheathment of neurons

[Term]
id: GO:0008369
name: obsolete molecular function
namespace: molecular_function
def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008370
name: obsolete cellular component
namespace: cellular_component
def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008371
name: obsolete biological process
namespace: biological_process
def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008373
name: sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [GOC:cjm, PMID:26192491]
xref: EC:2.4.3.-
xref: Reactome:R-HSA-9683769 "O-glycosylation of 3a is terminated"
xref: Reactome:R-HSA-9694718 "O-glycosylation of 3a is terminated"
xref: Reactome:R-HSA-9697018 "Addition of sialic acids on some Spike glycosyl sidechains"
xref: Reactome:R-HSA-981814 "ST6GALNAC2 transfers sialic acid to Core 1 mucins"
xref: Wikipedia:Sialyltransferase
is_a: GO:0016757 ! glycosyltransferase activity

[Term]
id: GO:0008374
name: O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: Reactome:R-HSA-1482775 "MLCL is acylated to CL by HADH (IM)"
xref: Reactome:R-HSA-1482781 "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)"
xref: Reactome:R-HSA-1482850 "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)"
xref: Reactome:R-HSA-1482861 "MLCL is acylated to CL by LCLAT1 (ER)"
xref: Reactome:R-HSA-1482867 "DLCL is acylated to MLCL by LCLAT1 (ER)"
xref: Reactome:R-HSA-162683 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH"
xref: Reactome:R-HSA-3238694 "PORCN palmitoleoylates N-glycosyl WNTs"
xref: Reactome:R-HSA-422017 "Ghrelin O-acyltransferase decanoylates Proghrelin"
xref: Reactome:R-HSA-422104 "Ghrelin O-acyltransferase octanoylates Proghrelin"
xref: Reactome:R-HSA-5358343 "HHAT palmitoylates Hh N-terminal fragment"
xref: Reactome:R-HSA-5483229 "HHAT G287V doesn't palmitoylate Hh-Np"
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0008375
name: acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]
synonym: "GlcNAc transferase activity" EXACT []
xref: Reactome:R-HSA-5694487 "A4GNT transfers GlcNAc to core 2 mucins"
xref: Reactome:R-HSA-8879117 "POMGNT2 transfers GlcNAc to Man-DAG1"
xref: Reactome:R-HSA-9683648 "Spike trimer glycoside chains are extended"
xref: Reactome:R-HSA-9694656 "Spike trimer glycoside chains are extended"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0008376
name: acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
synonym: "GalNAc transferase activity" EXACT []
xref: Reactome:R-HSA-8855954 "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD"
xref: Reactome:R-HSA-8931648 "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1"
xref: Reactome:R-HSA-9605700 "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0008377
name: obsolete light-induced release of internally sequestered calcium ion
namespace: biological_process
def: "OBSOLETE. The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai]
comment: This term was obsoleted because it represents the same pathway as phospholipase C-activating G protein-mediated phototransduction signaling pathway ; GO:0141189.
synonym: "light-induced release of calcium from internal store" EXACT []
synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT []
synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT []
is_obsolete: true
replaced_by: GO:0030265

[Term]
id: GO:0008378
name: galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
xref: Reactome:R-HSA-1964501 "Addition of galactose to Core 6 glycoprotein"
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0008379
name: thioredoxin peroxidase activity
namespace: molecular_function
alt_id: GO:0009031
def: "Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O." [RHEA:63528]
synonym: "thiol peroxidase activity" EXACT []
synonym: "TPx activity" EXACT []
synonym: "TrxPx activity" EXACT []
xref: MetaCyc:RXN0-267
xref: Reactome:R-HSA-3322995 "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O"
xref: Reactome:R-HSA-3341343 "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O"
xref: Reactome:R-HSA-3697882 "PRDX5 reduces peroxynitrite to nitrite using TXN"
xref: Reactome:R-HSA-3697894 "PRDX5 reduces peroxynitrite to nitrite using TXN2"
xref: RHEA:63528
is_a: GO:0140824 ! thioredoxin-dependent peroxiredoxin activity

[Term]
id: GO:0008380
name: RNA splicing
namespace: biological_process
alt_id: GO:0006395
def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
subset: goslim_yeast
synonym: "pre-mRNA splicing factor activity" RELATED []
xref: Wikipedia:RNA_splicing
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0008381
name: mechanosensitive monoatomic ion channel activity
namespace: molecular_function
alt_id: GO:0022833
def: "Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]
synonym: "mechanically gated channel activity" EXACT []
synonym: "mechanically-gated channel activity" EXACT []
synonym: "mechanically-gated ion channel activity" EXACT []
synonym: "mechanosensitive ion channel activity" BROAD []
xref: TC:1.A.23.2.1
is_a: GO:0005216 ! monoatomic ion channel activity
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0008384
name: IkappaB kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10]
comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
synonym: "ATP:IkappaB protein phosphotransferase activity" RELATED [EC:2.7.11.10]
synonym: "CHUK" RELATED [EC:2.7.11.10]
synonym: "IKBKA" RELATED [EC:2.7.11.10]
synonym: "IKBKB" RELATED [EC:2.7.11.10]
synonym: "IKK" RELATED [EC:2.7.11.10]
synonym: "IKK-1" RELATED [EC:2.7.11.10]
synonym: "IKK-2" RELATED [EC:2.7.11.10]
synonym: "inhibitor of NF-kappaB kinase activity" RELATED [EC:2.7.11.10]
synonym: "inhibitor of NFkappaB kinase activity" RELATED [EC:2.7.11.10]
synonym: "STK12" RELATED [EC:2.7.11.10]
synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10]
synonym: "TBK1" RELATED [EC:2.7.11.10]
xref: EC:2.7.11.10
xref: MetaCyc:2.7.11.10-RXN
xref: Reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex"
xref: Reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400"
xref: RHEA:19073
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0008385
name: IkappaB kinase complex
namespace: cellular_component
def: "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203]
synonym: "heterotrimeric IKK complex" EXACT [GOC:bf]
synonym: "IKK complex" EXACT []
synonym: "trimeric IKK complex" EXACT [PMID:21173796]
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0008386
name: cholesterol monooxygenase (side-chain-cleaving) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6]
synonym: "cholesterol 20-22-desmolase activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol C(20-22) desmolase activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol C20-22 desmolase activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol desmolase activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" RELATED [EC:1.14.15.6]
synonym: "Cyp11a1" NARROW []
synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6]
synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6]
synonym: "desmolase, steroid 20-22" RELATED [EC:1.14.15.6]
synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6]
synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6]
synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6]
xref: EC:1.14.15.6
xref: MetaCyc:1.14.15.6-RXN
xref: Reactome:R-HSA-193054 "Oxidation of cholesterol to 22beta-hydroxycholesterol"
xref: Reactome:R-HSA-193065 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol"
xref: Reactome:R-HSA-193101 "CYP11A1 cleaves 20a,22b-DHCHOL"
xref: RHEA:35739
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008387
name: steroid 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + AH2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah]
synonym: "cytochrome P450 CYP2A12" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008388
name: testosterone 15-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai]
synonym: "cytochrome P450 CYP2A4" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008389
name: coumarin 7-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [PMID:10490589, PMID:2733794]
synonym: "cytochrome P450 CYP2A5" NARROW []
xref: Reactome:R-HSA-211881 "Coumarin is 7-hydroxylated by CYP2A13"
xref: Reactome:R-HSA-76453 "Coumarin is 7-hydroxylated by CYP2A6"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008390
name: testosterone 16-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:53196]
synonym: "cytochrome P450 CYP2B10" NARROW []
synonym: "cytochrome P450 CYP2B9" NARROW []
synonym: "cytochrome P450 CYP2D10" NARROW []
synonym: "cytochrome P450 CYP2D11" NARROW []
synonym: "cytochrome P450 CYP2D9" NARROW []
xref: RHEA:53196
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008391
name: arachidonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water." [GOC:mah]
synonym: "arachidonic acid monooxygenase activity" EXACT []
synonym: "cytochrome P450 CYP2B19" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008392
name: arachidonate epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, PMID:18952572]
synonym: "arachidonic acid epoxygenase activity" EXACT []
synonym: "cytochrome P450 CYP2J5" NARROW []
synonym: "cytochrome P450 CYP2J6" NARROW []
xref: Reactome:R-HSA-211983 "CYP2J2 oxidises ARA"
is_a: GO:0008391 ! arachidonate monooxygenase activity

[Term]
id: GO:0008395
name: steroid hydroxylase activity
namespace: molecular_function
alt_id: GO:0008394
def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]
synonym: "cytochrome P450 CYP2G1" NARROW []
synonym: "olfactory-specific steroid hydroxylase activity" NARROW []
synonym: "steroid monooxygenase activity" EXACT []
xref: Reactome:R-HSA-191983 "Cholesterol is hydroxylated to 25-hydroxycholesterol"
xref: Reactome:R-HSA-191999 "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol"
xref: Reactome:R-HSA-192042 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al"
xref: Reactome:R-HSA-192054 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)"
xref: Reactome:R-HSA-192123 "CYP27A1 27-hydroxylates CHOL"
xref: Reactome:R-HSA-193060 "CYP19A1 hydroxylates ANDST to E1"
xref: Reactome:R-HSA-193143 "CYP19A1 hydroxylates TEST to EST17b"
xref: Reactome:R-HSA-193393 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol"
xref: Reactome:R-HSA-193460 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)"
xref: Reactome:R-HSA-193497 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al"
xref: Reactome:R-HSA-193713 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)"
xref: Reactome:R-HSA-193719 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al"
xref: Reactome:R-HSA-193737 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)"
xref: Reactome:R-HSA-193780 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al"
xref: Reactome:R-HSA-193787 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol"
xref: Reactome:R-HSA-193792 "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol"
xref: Reactome:R-HSA-193965 "CYP11B2 oxidises 18HCORST to ALDO"
xref: Reactome:R-HSA-193995 "CYP11B2 18-hydroxylates CORST to 18HCORST"
xref: Reactome:R-HSA-5601849 "Defective CYP19A1 does not convert ANDST to E1"
xref: Reactome:R-HSA-5602170 "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol"
xref: Reactome:R-HSA-6785244 "Defective CYP11B2 does not oxidise 18HCORST"
xref: Reactome:R-HSA-6785245 "Defective CYP11B2 does not oxidise CORST"
xref: Reactome:R-HSA-9035960 "Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol"
xref: Reactome:R-HSA-9758674 "CYP3A4 oxidizes PREDN,PREDL"
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0008396
name: oxysterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-oxocholesterol + H+ + NADPH = 7alpha-hydroxycholesterol + NADP+." [RHEA:68740]
synonym: "cytochrome P450 CYP7B1" NARROW []
xref: Reactome:R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated"
xref: Reactome:R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL"
xref: Reactome:R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL"
xref: Reactome:R-HSA-5602885 "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL"
xref: RHEA:68740
is_a: GO:0008387 ! steroid 7-alpha-hydroxylase activity

[Term]
id: GO:0008397
name: sterol 12-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 12-alpha-hydroxysteroid + oxidized [NADPH--hemoprotein reductase]- H2O +H+." [EC:1.14.14.139]
synonym: "cytochrome P450 CYP8B1" NARROW []
xref: EC:1.14.14.139
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008398
name: sterol 14-demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]." [RHEA:54028]
synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.14.154]
synonym: "cytochrome P450 CYP51" NARROW []
synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.14.154]
synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.14.154]
synonym: "lanosterol 14alpha-demethylase activity" RELATED [EC:1.14.14.154]
synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.14.154]
synonym: "sterol 14-alpha-demethylase activity" RELATED []
synonym: "sterol 14alpha-demethylase activity" RELATED []
xref: EC:1.14.14.154
xref: MetaCyc:1.14.13.70-RXN
xref: RHEA:54028
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0008399
name: naphthalene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide." [PMID:1742282, PMID:1981702]
synonym: "cytochrome P450 CYP2F2" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008401
name: retinoic acid 4-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid." [PMID:19519282, PMID:9250660]
synonym: "cytochrome P450 CYP261" NARROW []
xref: Reactome:R-HSA-211874 "CYP2S1 4-hydroxylates atRA"
xref: Reactome:R-HSA-211923 "CYP26C1 4-hydroxylates 9cRA"
xref: Reactome:R-HSA-212007 "CYP26A1,B1 4-hydroxylate atRA"
xref: Reactome:R-HSA-5362525 "CYP26A1,B1,C1 4-hydroxylate atRA"
xref: Reactome:R-HSA-5602050 "Defective CYP26C1 does not 4-hydroxylate 9cRA"
xref: Reactome:R-HSA-5602063 "Defective CYP26B1 does not 4-hydroxylate atRA"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008403
name: 25-hydroxycholecalciferol-24-hydroxylase activity
namespace: molecular_function
alt_id: GO:0030344
def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309]
synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT []
synonym: "cytochrome P450 CYP24" NARROW []
xref: RHEA:24968
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0070576 ! vitamin D 24-hydroxylase activity

[Term]
id: GO:0008404
name: arachidonate 14,15-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, RHEA:51472]
synonym: "arachidonic acid 14,15-epoxygenase activity" EXACT []
synonym: "cytochrome P450 CYP2C29" NARROW []
synonym: "cytochrome P450 CYP2C39" NARROW []
xref: RHEA:51472
is_a: GO:0008392 ! arachidonate epoxygenase activity

[Term]
id: GO:0008405
name: arachidonate 11,12-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, RHEA:51480]
synonym: "arachidonic acid 11,12-epoxygenase activity" EXACT []
synonym: "cytochrome P450 CYP2C38" NARROW []
xref: RHEA:51480
is_a: GO:0008392 ! arachidonate epoxygenase activity

[Term]
id: GO:0008406
name: gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
synonym: "gonadogenesis" EXACT [GOC:cjm]
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0045137 ! development of primary sexual characteristics

[Term]
id: GO:0008407
name: chaeta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
synonym: "bristle morphogenesis" NARROW [GOC:bf, GOC:dos]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0022416 ! chaeta development

[Term]
id: GO:0008408
name: 3'-5' exonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
synonym: "3'-5'-exonuclease activity" EXACT []
xref: Reactome:R-HSA-3245943 "Viral DNA cleavage by TREX1"
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0008409
name: 5'-3' exonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai]
xref: Reactome:R-HSA-5358599 "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch"
xref: Reactome:R-HSA-5358619 "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL)"
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0008410
name: CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl]
xref: EC:2.8.3.-
is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups

[Term]
id: GO:0008411
name: 4-hydroxybutyrate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl, PMID:25452282]
xref: MetaCyc:RXN-8889
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008412
name: 4-hydroxybenzoate polyprenyltransferase activity
namespace: molecular_function
alt_id: GO:0000043
alt_id: GO:0048043
alt_id: GO:0048044
def: "Catalysis of the reaction: 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate." [RHEA:44504]
synonym: "4-HB polyprenyltransferase activity" EXACT []
synonym: "4-hydroxybenzoate nonaprenyltransferase activity" NARROW [EC:2.5.1.39]
synonym: "para-hydroxybenzoate transferase activity" EXACT []
synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT []
synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT []
synonym: "PHB polyprenyl diphosphate transferase activity" EXACT []
xref: EC:2.5.1.39
xref: MetaCyc:RXN-11368
xref: RHEA:44504
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0008413
name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881, RHEA:60032]
synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT []
synonym: "8-oxo-7,8-dihydroguanine triphosphatase activity" EXACT []
synonym: "8-oxo-7,8-dihydroguanosine triphosphatase activity" EXACT []
synonym: "8-oxo-GTPase activity" EXACT []
xref: EC:3.6.1.69
xref: RHEA:60032
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0008414
name: CDP-alcohol phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl]
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0008417
name: fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
xref: Reactome:R-HSA-9033949 "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC"
xref: Reactome:R-HSA-9846332 "FUT1,2 transfer fucose to gangliosides"
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0008418
name: protein-N-terminal asparagine amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481, RHEA:50676]
xref: EC:3.5.1.121
xref: RHEA:50676
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008419
name: RNA lariat debranching enzyme activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612]
xref: EC:3.1.26.1
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008420
name: RNA polymerase II CTD heptapeptide repeat phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]
synonym: "CTD phosphatase activity" EXACT []
synonym: "RNA polymerase II carboxy-terminal domain phosphatase activity" EXACT []
is_a: GO:0004722 ! protein serine/threonine phosphatase activity
is_a: GO:0140994 ! RNA polymerase II CTD heptapeptide repeat modifying activity

[Term]
id: GO:0008421
name: long-chain fatty-acyl-glutamate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55]
synonym: "long-chain acylglutamate amidase activity" RELATED [EC:3.5.1.55]
synonym: "long-chain aminoacylase activity" RELATED [EC:3.5.1.55]
synonym: "long-chain fatty acyl-glutamate deacylase activity" EXACT [GOC:mah]
synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT []
synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.55]
xref: EC:3.5.1.55
xref: MetaCyc:3.5.1.55-RXN
xref: RHEA:17517
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008422
name: beta-glucosidase activity
namespace: molecular_function
alt_id: GO:0016983
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21, PMID:12594539]
synonym: "amygdalase activity" NARROW [EC:3.2.1.21]
synonym: "amygdalinase" NARROW [EC:3.2.1.21]
synonym: "arbutinase activity" NARROW []
synonym: "aryl-beta-glucosidase activity" RELATED [EC:3.2.1.21]
synonym: "beta-1,6-glucosidase activity" RELATED [EC:3.2.1.21]
synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "beta-D-glucoside glucohydrolase activity" RELATED [EC:3.2.1.21]
synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21]
synonym: "cellobiase activity" NARROW [EC:3.2.1.21]
synonym: "cytokine beta-glucosidase activity" NARROW []
synonym: "elaterase activity" NARROW []
synonym: "emulsin" RELATED [EC:3.2.1.21]
synonym: "gentiobiase activity" NARROW []
synonym: "gentobiase activity" NARROW [EC:3.2.1.21]
synonym: "limarase activity" NARROW []
synonym: "p-nitrophenyl beta-glucosidase activity" NARROW []
synonym: "primeverosidase activity" NARROW []
synonym: "quercetin 3'-O-beta-D-glucopyranoside hydrolase activity" NARROW []
synonym: "quercetin 4'-O-beta-D-glucopyranoside hydrolase activity" NARROW []
synonym: "salicilinase activity" NARROW []
xref: EC:3.2.1.21
xref: MetaCyc:3.2.1.21-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0008423
name: obsolete bleomycin hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40]
synonym: "bleomycin hydrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0008424
name: glycoprotein 6-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H+." [EC:2.4.1.68, RHEA:12985]
synonym: "FucT" RELATED [EC:2.4.1.68]
synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity" RELATED [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" RELATED [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity" RELATED [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" RELATED [EC:2.4.1.68]
synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68]
synonym: "GDPfucose-glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68]
synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68]
synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68]
xref: EC:2.4.1.68
xref: KEGG_REACTION:R05988
xref: MetaCyc:2.4.1.68-RXN
xref: Reactome:R-HSA-1028788 "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP"
xref: Reactome:R-HSA-9696980 "Spike trimer glycoside chains get additional branches"
xref: RHEA:12985
is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0008425
name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:23190198, PMID:9083048]
comment: Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT []
synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT []
synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD []
synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD []
xref: EC:2.1.1.201
xref: Reactome:R-HSA-2162188 "COQ5 methylates MDMQ10H2"
xref: RHEA:28286
is_a: GO:0008169 ! C-methyltransferase activity

[Term]
id: GO:0008426
name: protein kinase C inhibitor activity
namespace: molecular_function
alt_id: GO:0004863
def: "Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai]
synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT []
synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT []
synonym: "PKC inhibitor activity" EXACT []
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity

[Term]
id: GO:0008427
name: calcium-dependent protein kinase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah]
is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity

[Term]
id: GO:0008428
name: ribonuclease inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of ribonuclease." [GOC:ai]
synonym: "RNA nuclease inhibitor activity" EXACT []
is_a: GO:0140721 ! nuclease inhibitor activity

[Term]
id: GO:0008429
name: phosphatidylethanolamine binding
namespace: molecular_function
def: "Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0008430
name: selenium binding
namespace: molecular_function
def: "Binding to a selenium (Se) ion." [GOC:ai]
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0008431
name: vitamin E binding
namespace: molecular_function
def: "Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [ISBN:0721662544]
synonym: "alpha-tocopherol binding" NARROW []
synonym: "tocopherol binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0008432
name: JUN kinase binding
namespace: molecular_function
def: "Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl]
synonym: "JNK binding" EXACT [GOC:BHF, GOC:ebc]
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0008435
name: obsolete anticoagulant activity
namespace: molecular_function
def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732]
comment: This term was made obsolete because it represents a biological process.
synonym: "anticoagulant activity" EXACT []
is_obsolete: true
replaced_by: GO:0050819

[Term]
id: GO:0008436
name: obsolete heterogeneous nuclear ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "heterogeneous nuclear ribonucleoprotein" EXACT []
synonym: "hnRNP" EXACT []
is_obsolete: true
replaced_by: GO:1990904

[Term]
id: GO:0008437
name: thyrotropin-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732]
synonym: "thyrotropin releasing hormone activity" EXACT []
synonym: "TRH activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0008438
name: obsolete 1-phosphatidylinositol-5-phosphate kinase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [GOC:curators]
comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref.
synonym: "1-phosphatidylinositol-5-phosphate kinase" EXACT []
is_obsolete: true
consider: GO:0016309

[Term]
id: GO:0008439
name: obsolete monophenol monooxygenase activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "monophenol monooxygenase activator activity" EXACT []
synonym: "prophenol oxidase activator" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008440
name: inositol-1,4,5-trisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+." [RHEA:11020]
synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" BROAD []
synonym: "inositol trisphosphate 3-kinase activity" BROAD []
synonym: "inositol-trisphosphate 3-kinase activity" BROAD []
synonym: "Ins(1,4,5)P3 3-kinase activity" RELATED [EC:2.7.1.127]
synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127]
synonym: "IP3K activity" NARROW [EC:2.7.1.127]
xref: EC:2.7.1.127
xref: KEGG_REACTION:R03433
xref: MetaCyc:2.7.1.127-RXN
xref: Reactome:R-HSA-1855153 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol"
xref: Reactome:R-HSA-1855233 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus"
xref: RHEA:11020
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0008441
name: 3'(2'),5'-bisphosphate nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7]
synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT []
synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" RELATED [EC:3.1.3.7]
synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" RELATED [EC:3.1.3.7]
synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" RELATED [EC:3.1.3.7]
synonym: "DPNPase activity" RELATED [EC:3.1.3.7]
synonym: "phosphoadenylate 3'-nucleotidase activity" RELATED [EC:3.1.3.7]
xref: EC:3.1.3.7
xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN
xref: Reactome:R-HSA-176606 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:R-HSA-8953499 "IMPAD1 hydrolyses PAP to AMP"
xref: RHEA:10040
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008442
name: 3-hydroxyisobutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31]
xref: EC:1.1.1.31
xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-508473 "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+"
xref: Reactome:R-HSA-70885 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+"
xref: RHEA:17681
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008443
name: phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule." [GOC:jl]
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008444
name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+." [EC:2.7.8.5, RHEA:12593]
synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" RELATED [EC:2.7.8.5]
synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "glycerol 3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "glycerol phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "glycerophosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
synonym: "PGP synthase activity" RELATED [EC:2.7.8.5]
synonym: "phosphatidylglycerol phosphate synthase activity" RELATED [EC:2.7.8.5]
synonym: "phosphatidylglycerol phosphate synthetase activity" RELATED [EC:2.7.8.5]
synonym: "phosphatidylglycerolphosphate synthase activity" RELATED [EC:2.7.8.5]
synonym: "phosphatidylglycerophosphate synthase activity" RELATED [EC:2.7.8.5]
synonym: "phosphatidylglycerophosphate synthetase activity" RELATED [EC:2.7.8.5]
synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5]
xref: EC:2.7.8.5
xref: KEGG_REACTION:R01801
xref: MetaCyc:PHOSPHAGLYPSYN-RXN
xref: Reactome:R-HSA-1482939 "CDP-DAG is converted to PGP by PGS1"
xref: RHEA:12593
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0008445
name: D-aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aspartate + H2O + O2 = H2O2 + NH4+ + oxaloacetate." [RHEA:12512]
synonym: "aspartic oxidase activity" RELATED [EC:1.4.3.1]
synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.1]
synonym: "D-aspartic oxidase activity" RELATED [EC:1.4.3.1]
xref: EC:1.4.3.1
xref: Reactome:R-HSA-6810076 "DDO oxidizes D-Asp to OA"
xref: RHEA:12512
is_a: GO:0003884 ! D-amino-acid oxidase activity

[Term]
id: GO:0008446
name: GDP-mannose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O." [EC:4.2.1.47, RHEA:23820]
synonym: "GDP-D-mannose 4,6-dehydratase activity" RELATED [EC:4.2.1.47]
synonym: "GDP-D-mannose dehydratase activity" RELATED [EC:4.2.1.47]
synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" RELATED [EC:4.2.1.47]
synonym: "GDP-mannose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.47]
synonym: "GDPmannose 4,6-dehydratase activity" RELATED [EC:4.2.1.47]
synonym: "Gmd" RELATED [EC:4.2.1.47]
synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" RELATED [EC:4.2.1.47]
synonym: "guanosine diphosphomannose 4,6-dehydratase activity" RELATED [EC:4.2.1.47]
synonym: "guanosine diphosphomannose oxidoreductase activity" RELATED [EC:4.2.1.47]
xref: EC:4.2.1.47
xref: KEGG_REACTION:R00888
xref: MetaCyc:GDPMANDEHYDRA-RXN
xref: Reactome:R-HSA-6787632 "GMDS dehydrates GDP-Man to GDP-DHDMan"
xref: RHEA:23820
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008447
name: L-ascorbate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O." [RHEA:30243]
synonym: "AA oxidase activity" RELATED [EC:1.10.3.3]
synonym: "AAO" RELATED [EC:1.10.3.3]
synonym: "ascorbase activity" RELATED [EC:1.10.3.3]
synonym: "ascorbate dehydrogenase activity" RELATED [EC:1.10.3.3]
synonym: "ascorbate oxidase activity" RELATED [EC:1.10.3.3]
synonym: "ascorbic acid oxidase activity" RELATED [EC:1.10.3.3]
synonym: "ascorbic oxidase activity" RELATED [EC:1.10.3.3]
synonym: "L-ascorbate:O2 oxidoreductase activity" RELATED [EC:1.10.3.3]
synonym: "L-ascorbate:oxygen oxidoreductase activity" RELATED [EC:1.10.3.3]
synonym: "L-ascorbic acid oxidase activity" RELATED [EC:1.10.3.3]
xref: EC:1.10.3.3
xref: MetaCyc:RXN-3541
xref: RHEA:30243
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0008448
name: N-acetylglucosamine-6-phosphate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate." [RHEA:22936]
synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" RELATED [EC:3.5.1.25]
synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" RELATED [EC:3.5.1.25]
synonym: "acetylglucosamine phosphate deacetylase activity" RELATED [EC:3.5.1.25]
synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" RELATED [EC:3.5.1.25]
xref: EC:3.5.1.25
xref: MetaCyc:NAG6PDEACET-RXN
xref: Reactome:R-HSA-6803789 "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA"
xref: RHEA:22936
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008449
name: N-acetylglucosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]
synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" RELATED [EC:3.1.6.14]
synonym: "acetylglucosamine 6-sulfatase activity" RELATED [EC:3.1.6.14]
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14]
synonym: "glucosamine-6-sulfatase activity" RELATED [EC:3.1.6.14]
synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" RELATED [EC:3.1.6.14]
synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" RELATED [EC:3.1.6.14]
synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT []
synonym: "O,N-disulfate O-sulfohydrolase activity" RELATED [EC:3.1.6.14]
xref: EC:3.1.6.14
xref: MetaCyc:3.1.6.14-RXN
xref: Reactome:R-HSA-1638032 "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate"
xref: Reactome:R-HSA-2263495 "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S"
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0008450
name: obsolete O-sialoglycoprotein endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "glycophorin A proteinase activity" RELATED []
synonym: "glycoprotease activity" RELATED []
synonym: "glycoproteinase activity" RELATED []
synonym: "O-sialoglycoprotein endopeptidase activity" EXACT []
synonym: "sialoglycoprotease activity" RELATED []
synonym: "sialoglycoproteinase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008451
name: obsolete X-Pro aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoacylproline aminopeptidase activity" RELATED [EC:3.4.11.9]
synonym: "aminopeptidase P" EXACT []
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9]
synonym: "X-Pro aminopeptidase activity" EXACT []
synonym: "Xaa-Pro aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0008452
name: RNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the phosphate group at the end of another." [GOC:mah]
subset: gocheck_do_not_annotate
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0008453
name: alanine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44]
synonym: "AGT activity" RELATED [EC:2.6.1.44]
synonym: "alanine--glyoxylate aminotransferase activity" RELATED [EC:2.6.1.44]
synonym: "alanine-glyoxylate aminotransferase activity" EXACT []
synonym: "alanine-glyoxylic aminotransferase activity" RELATED [EC:2.6.1.44]
synonym: "L-alanine-glycine transaminase activity" RELATED [EC:2.6.1.44]
synonym: "L-alanine:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.44]
xref: EC:2.6.1.44
xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-389684 "glyoxylate + alanine => glycine + pyruvate [peroxisome]"
xref: Reactome:R-HSA-904864 "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate"
xref: RHEA:24248
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008454
name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145]
synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.145]
synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "beta-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145]
synonym: "GnTIV activity" RELATED [EC:2.4.1.145]
synonym: "N-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145]
synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.145]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145]
xref: EC:2.4.1.145
xref: MetaCyc:2.4.1.145-RXN
xref: Reactome:R-HSA-9696980 "Spike trimer glycoside chains get additional branches"
xref: Reactome:R-HSA-975903 "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV"
xref: RHEA:16057
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0008455
name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143]
synonym: "acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.143]
synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "GnTII activity" RELATED [EC:2.4.1.143]
synonym: "N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.143]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.143]
synonym: "UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143]
xref: EC:2.4.1.143
xref: MetaCyc:2.4.1.143-RXN
xref: Reactome:R-HSA-4793955 "Defective MGAT2 does not transfer GlcNAc to N-glycans"
xref: Reactome:R-HSA-9694656 "Spike trimer glycoside chains are extended"
xref: Reactome:R-HSA-975829 "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2"
xref: RHEA:12941
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0008456
name: alpha-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49]
synonym: "alpha-acetylgalactosaminidase activity" RELATED [EC:3.2.1.49]
synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49]
synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" RELATED [EC:3.2.1.49]
synonym: "alpha-NAGA activity" RELATED [EC:3.2.1.49]
synonym: "N-acetyl-alpha-D-galactosaminidase activity" RELATED [EC:3.2.1.49]
synonym: "N-acetyl-alpha-galactosaminidase activity" RELATED [EC:3.2.1.49]
xref: EC:3.2.1.49
xref: MetaCyc:3.2.1.49-RXN
xref: RHEA:15085
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0008457
name: obsolete beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ; GO:0008532.
synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD []
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008532

[Term]
id: GO:0008458
name: carnitine O-octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine." [RHEA:17177]
synonym: "carnitine medium-chain acyltransferase activity" RELATED [EC:2.3.1.137]
synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137]
synonym: "medium-chain/long-chain carnitine acyltransferase activity" RELATED [EC:2.3.1.137]
synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" RELATED [EC:2.3.1.137]
synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137]
xref: EC:2.3.1.137
xref: KEGG_REACTION:R03779
xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN
xref: Reactome:R-HSA-390281 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH"
xref: RHEA:17177
is_a: GO:0016406 ! carnitine O-acyltransferase activity

[Term]
id: GO:0008459
name: chondroitin 6-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17]
synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" RELATED [EC:2.8.2.17]
synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" RELATED [EC:2.8.2.17]
synonym: "chondroitin 6-O-sulfotransferase activity" RELATED [EC:2.8.2.17]
synonym: "chondroitin 6-sulphotransferase activity" EXACT []
synonym: "terminal 6-sulfotransferase activity" RELATED [EC:2.8.2.17]
xref: EC:2.8.2.17
xref: KEGG_REACTION:R02181
xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-2018682 "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains"
xref: Reactome:R-HSA-3595175 "Defective CHST3 does not transfer SO4(2-) to chondroitin"
xref: RHEA:11108
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0008460
name: dTDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O." [EC:4.2.1.46, RHEA:17221]
synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" RELATED [EC:4.2.1.46]
synonym: "dTDP-glucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.46]
synonym: "dTDPglucose 4,6-dehydratase activity" RELATED [EC:4.2.1.46]
synonym: "dTDPglucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.46]
synonym: "TDP-glucose oxidoreductase activity" RELATED [EC:4.2.1.46]
synonym: "thymidine diphosphoglucose oxidoreductase activity" RELATED [EC:4.2.1.46]
xref: EC:4.2.1.46
xref: KEGG_REACTION:R06513
xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN
xref: RHEA:17221
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008462
name: obsolete endopeptidase Clp activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP-dependent Clp protease" NARROW []
synonym: "caseinolytic protease activity" RELATED []
synonym: "Clp protease" NARROW []
synonym: "ClpP" RELATED []
synonym: "endopeptidase Clp activity" EXACT []
synonym: "endopeptidase Ti activity" RELATED []
synonym: "protease Ti activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008463
name: formylmethionine deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-methionine + H2O = L-methionine + formate." [EC:3.5.1.31, RHEA:17781]
synonym: "N-formyl-L-methionine amidohydrolase activity" RELATED [EC:3.5.1.31]
xref: EC:3.5.1.31
xref: KEGG_REACTION:R00653
xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN
xref: RHEA:17781
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008464
name: obsolete gamma-glutamyl hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "gamma-glutamyl hydrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008242

[Term]
id: GO:0008465
name: hydroxypyruvate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NAD+ = 3-hydroxypyruvate + NADH + H+." [EC:1.1.1.29]
synonym: "glycerate dehydrogenase (NAD+) activity" EXACT []
synonym: "glycerate dehydrogenase activity" BROAD []
synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29]
xref: EC:1.1.1.29
xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN
xref: RHEA:17905
is_a: GO:0016618 ! hydroxypyruvate reductase [NAD(P)H] activity

[Term]
id: GO:0008466
name: glycogenin glucosyltransferase activity
namespace: molecular_function
alt_id: GO:0047210
def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. This first reaction is a self glucosylation. Further UDP-glucose goups are added to the [1,4-alpha-D-glucosyl](n) group of glycogenin until a length of about 5-13 residues." [EC:2.4.1.186]
synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT []
synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT []
synonym: "glycogenin activity" RELATED [EC:2.4.1.186]
synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186]
synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.186]
synonym: "UDP-glucose:glycogenin glucosyltransferase activity" RELATED [EC:2.4.1.186]
xref: EC:2.4.1.186
xref: Reactome:R-HSA-3322003 "Autoglucosylation of GYG1 complexed with GYS1-b"
xref: Reactome:R-HSA-3322014 "Autoglucosylation of GYG2 complexed with GYS2-a"
xref: Reactome:R-HSA-3322019 "Autoglucosylation of GYG2 complexed with GYS2-b"
xref: Reactome:R-HSA-3322025 "Autoglucosylation of GYG1 complexed with GYS1-a"
xref: Reactome:R-HSA-3814838 "Defective GYG1 is not autoglucosyolated"
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008467
name: heparan sulfate 3-sulfotransferase 1 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. The (heparan sulfate)-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23]
synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23]
synonym: "3-OST-1 activity" RELATED [EC:2.8.2.23]
synonym: "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity" EXACT []
synonym: "glucosaminyl 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23]
synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED []
synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED []
synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23]
xref: EC:2.8.2.23
xref: MetaCyc:2.8.2.23-RXN
xref: Reactome:R-HSA-2076383 "HS3ST1 sulfates GlcN at C3 in heparan sulfate"
xref: Reactome:R-HSA-2076611 "HS3STs sulfate GlcN at C3 in heparan sulfate"
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0008469
name: histone arginine N-methyltransferase activity
namespace: molecular_function
alt_id: GO:0016276
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [PMID:8002954]
synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah]
synonym: "histone-arginine N-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT []
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0042054 ! histone methyltransferase activity

[Term]
id: GO:0008470
name: 3-methylbutanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]." [PMID:25450250, PMID:7640268, RHEA:12276]
synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" RELATED [EC:1.3.8.4]
synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" RELATED [EC:1.3.8.4]
synonym: "isovaleroyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.4]
synonym: "isovaleryl-CoA dehydrogenase activity" EXACT []
synonym: "isovaleryl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.4]
xref: EC:1.3.8.4
xref: MetaCyc:RXN0-2301
xref: Reactome:R-HSA-70745 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2"
xref: Reactome:R-HSA-9914837 "IVD mutants don't synthesize beta-methylcrotonyl-CoA"
xref: RHEA:12276
is_a: GO:0016937 ! short-chain fatty acyl-CoA dehydrogenase activity

[Term]
id: GO:0008471
name: obsolete laccase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2]
synonym: "benzenediol:oxygen oxidoreductase activity" RELATED [EC:1.10.3.2]
synonym: "laccase activity" EXACT []
synonym: "p-diphenol oxidase activity" RELATED [EC:1.10.3.2]
synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2]
synonym: "urushiol oxidase activity" RELATED [EC:1.10.3.2]
is_obsolete: true
replaced_by: GO:0016682

[Term]
id: GO:0008472
name: obsolete metallocarboxypeptidase D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22]
synonym: "gp180 (duck)" RELATED [EC:3.4.17.22]
synonym: "metallocarboxypeptidase D activity" EXACT []
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0008473
name: ornithine cyclodeaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine = L-proline + NH4." [EC:4.3.1.12, RHEA:24368]
comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases.
synonym: "L-ornithine ammonia-lyase (cyclizing)" RELATED [EC:4.3.1.12]
synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" RELATED [EC:4.3.1.12]
synonym: "OCD activity" RELATED [EC:4.3.1.12]
synonym: "ornithine cyclase (deaminating) activity" RELATED [EC:4.3.1.12]
synonym: "ornithine cyclase activity" RELATED [EC:4.3.1.12]
xref: EC:4.3.1.12
xref: KEGG_REACTION:R00671
xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN
xref: RHEA:24368
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008474
name: palmitoyl-(protein) hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]
subset: goslim_chembl
synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22]
synonym: "palmitoyl-protein hydrolase activity" EXACT []
synonym: "palmitoyl-protein thioesterase activity" EXACT []
synonym: "palmitoyl-protein thiolesterase activity" EXACT []
xref: EC:3.1.2.22
xref: MetaCyc:3.1.2.22-RXN
xref: Reactome:R-HSA-203613 "Depalmitoylation of eNOS"
xref: Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins"
xref: Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"
xref: Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated"
xref: RHEA:19233
is_a: GO:0016790 ! thiolester hydrolase activity
is_a: GO:0098599 ! palmitoyl hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008475
name: procollagen-lysine 5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4]
synonym: "collagen lysine hydroxylase activity" RELATED [EC:1.14.11.4]
synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4]
synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4]
synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4]
synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4]
synonym: "lysylprotocollagen dioxygenase activity" RELATED [EC:1.14.11.4]
synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.11.4]
synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" RELATED [EC:1.14.11.4]
synonym: "protocollagen lysine dioxygenase activity" RELATED [EC:1.14.11.4]
synonym: "protocollagen lysine hydroxylase activity" RELATED [EC:1.14.11.4]
synonym: "protocollagen lysyl hydroxylase activity" RELATED [EC:1.14.11.4]
xref: EC:1.14.11.4
xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN
xref: Reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines"
xref: RHEA:16569
is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity

[Term]
id: GO:0008476
name: protein-tyrosine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" RELATED [EC:2.8.2.20]
synonym: "protein-tyrosine sulphotransferase activity" EXACT []
synonym: "tyrosylprotein sulfotransferase activity" RELATED [EC:2.8.2.20]
xref: EC:2.8.2.20
xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-8954262 "TPST1,2 transfer SO4(2-) from PAPS to PODXL2"
xref: Reactome:R-HSA-9668023 "TPST1,2 transfer SO4(2-) from PAPS to FVIII"
xref: Reactome:R-HSA-9668148 "F8 variant is not sulfonated at Y1699"
xref: RHEA:16801
is_a: GO:0008146 ! sulfotransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008477
name: purine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1]
synonym: "IAG-NH activity" RELATED [EC:3.2.2.1]
synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1]
synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1]
synonym: "N-D-ribosylpurine ribohydrolase activity" RELATED [EC:3.2.2.1]
synonym: "N-ribosyl purine ribohydrolase activity" RELATED [EC:3.2.2.1]
synonym: "nucleosidase activity" BROAD [EC:3.2.2.1]
synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1]
synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1]
synonym: "purine beta-ribosidase activity" RELATED [EC:3.2.2.1]
synonym: "purine nucleosidase reaction" EXACT []
synonym: "purine nucleoside hydrolase activity" RELATED [EC:3.2.2.1]
synonym: "purine ribonucleosidase activity" RELATED [EC:3.2.2.1]
synonym: "purine-nucleoside ribohydrolase activity" RELATED [EC:3.2.2.1]
synonym: "purine-specific nucleoside N-ribohydrolase activity" RELATED [EC:3.2.2.1]
synonym: "ribonucleoside hydrolase activity" RELATED [EC:3.2.2.1]
xref: EC:3.2.2.1
xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN
xref: RHEA:23344
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008478
name: pyridoxal kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35]
synonym: "ATP:pyridoxal 5'-phosphotransferase activity" RELATED [EC:2.7.1.35]
synonym: "pyridoxal 5-phosphate-kinase activity" RELATED [EC:2.7.1.35]
synonym: "pyridoxal kinase (phosphorylating)" RELATED [EC:2.7.1.35]
synonym: "pyridoxal phosphokinase activity" RELATED [EC:2.7.1.35]
synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35]
synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35]
synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35]
synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35]
xref: EC:2.7.1.35
xref: MetaCyc:PYRIDOXKIN-RXN
xref: Reactome:R-HSA-964958 "2xPDXK:2xZn2+ phosphorylates PXA"
xref: Reactome:R-HSA-964962 "2xPDKX:2xZn2+ phosphorylates PDX"
xref: Reactome:R-HSA-964970 "2xPDXK:2xZn2+ phosphorylates PXL"
xref: RHEA:10224
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008479
name: tRNA-guanosine(34) queuine transglycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA." [RHEA:16633]
synonym: "eTGT" EXACT []
synonym: "guanine insertion enzyme" RELATED [EC:2.4.2.64]
synonym: "Q-insertase" BROAD [EC:2.4.2.64]
synonym: "queuine tRNA-ribosyltransferase" EXACT [EC:2.4.2.64]
synonym: "queuine tRNA-ribosyltransferase activity" BROAD []
synonym: "queuine(34) transfer ribonucleate ribosyltransferase" EXACT [EC:2.4.2.64]
synonym: "TGT" BROAD [EC:2.4.2.64]
synonym: "tRNA guanine transglycosylase" BROAD []
synonym: "tRNA transglycosylase" BROAD [EC:2.4.2.64]
synonym: "tRNA-guanosine(34) queuine transglycosylase" EXACT [EC:2.4.2.64]
xref: EC:2.4.2.64
xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-6782443 "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)"
xref: RHEA:16633
is_a: GO:0016763 ! pentosyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0008480
name: sarcosine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.3, RHEA:19793]
comment: Note that this was EC:1.5.99.1.
synonym: "monomethylglycine dehydrogenase activity" RELATED [EC:1.5.8.3]
synonym: "sarcosine N-demethylase activity" RELATED [EC:1.5.8.3]
synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" RELATED [EC:1.5.8.3]
synonym: "sarcosine:acceptor oxidoreductase (demethylating)" RELATED [EC:1.5.8.3]
xref: EC:1.5.8.3
xref: KEGG_REACTION:R00611
xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-6797913 "SARDH:FAD oxidatively demethylates SARC to Gly"
xref: RHEA:19793
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0008481
name: sphingosine kinase activity
namespace: molecular_function
alt_id: GO:0001728
def: "Catalysis of the reaction: a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H+." [RHEA:51496]
synonym: "ATP:sphinganine 1-phosphotransferase activity" RELATED [EC:2.7.1.91]
synonym: "dihydrosphingosine kinase (phosphorylating)" RELATED [EC:2.7.1.91]
synonym: "dihydrosphingosine kinase activity" RELATED [EC:2.7.1.91]
synonym: "sphinganine kinase activity" RELATED []
synonym: "sphingosine kinase (phosphorylating)" RELATED [EC:2.7.1.91]
xref: EC:2.7.1.91
xref: MetaCyc:SPHINGANINE-KINASE-RXN
xref: RHEA:51496
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008482
name: sulfite oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate." [RHEA:24600]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "sulfite:oxygen oxidoreductase activity" RELATED [EC:1.8.3.1]
synonym: "sulphite oxidase activity" EXACT []
xref: EC:1.8.3.1
xref: KEGG_REACTION:R00533
xref: MetaCyc:SULFITE-OXIDASE-RXN
xref: Reactome:R-HSA-1614544 "Sulfite is oxidized to sulfate"
xref: RHEA:24600
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0008483
name: transaminase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [EC:2.6.1.-]
synonym: "aminotransferase activity" EXACT []
xref: EC:2.6.1.-
xref: Reactome:R-HSA-1237102 "Transamination of MOB to methionine"
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0008484
name: sulfuric ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
synonym: "sulfatase activity" EXACT []
synonym: "sulphuric ester hydrolase activity" EXACT []
xref: EC:3.1.6.-
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0008486
name: diphosphoinositol-polyphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate." [EC:3.6.1.52]
synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52]
synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT []
synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52]
synonym: "DIPP activity" RELATED [EC:3.6.1.52]
xref: EC:3.6.1.52
xref: KEGG_REACTION:R05777
xref: MetaCyc:3.6.1.52-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008487
name: obsolete prenyl-dependent CAAX protease activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "prenyl-dependent CAAX protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008488
name: gamma-glutamyl carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194]
xref: EC:4.1.1.90
xref: Reactome:R-HSA-159752 "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)"
xref: Reactome:R-HSA-159761 "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)"
xref: Reactome:R-HSA-159795 "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)"
xref: Reactome:R-HSA-159803 "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)"
xref: Reactome:R-HSA-159819 "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)"
xref: Reactome:R-HSA-159826 "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)"
xref: Reactome:R-HSA-163810 "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)"
xref: Reactome:R-HSA-163820 "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)"
xref: Reactome:R-HSA-6807214 "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)"
xref: Reactome:R-HSA-9673231 "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)"
xref: RHEA:45140
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008489
name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H+ + UDP." [PMID:9593693, RHEA:31495]
synonym: "LacCer synthase activity" EXACT []
synonym: "lactosylceramide synthase activity" EXACT []
synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT []
xref: EC:2.4.1.274
xref: MetaCyc:RXN-12119
xref: Reactome:R-HSA-9851347 "B4GALT5/6 transfer Gal to GlcCer"
xref: RHEA:31495
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008490
name: arsenite secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008491
def: "Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:jl]
synonym: "arsenite porter activity" RELATED []
is_a: GO:0015105 ! arsenite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008492
name: obsolete cAMP generating peptide activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product.
synonym: "cAMP generating peptide activity" EXACT []
synonym: "cyclic AMP generating peptide activity" EXACT []
is_obsolete: true
consider: GO:0004016
consider: GO:0005179
consider: GO:0046058

[Term]
id: GO:0008493
name: tetracycline transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators]
synonym: "tetracyclin transporter activity" EXACT []
synonym: "tetracycline transporter activity" RELATED []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0008494
name: translation activator activity
namespace: molecular_function
def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding

[Term]
id: GO:0008495
name: protoheme IX farnesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate." [RHEA:28070]
synonym: "haem O synthase activity" EXACT []
synonym: "heme A:farnesyltransferase activity" EXACT [PMID:9177788]
synonym: "heme O synthase activity" EXACT []
synonym: "protohaem IX farnesyltransferase activity" EXACT []
xref: EC:2.5.1.141
xref: MetaCyc:HEMEOSYN-RXN
xref: Reactome:R-HSA-2995330 "COX10 transforms heme to heme O"
xref: RHEA:28070
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0008496
name: mannan endo-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans." [EC:3.2.1.101]
synonym: "1,6-alpha-D-mannan mannanohydrolase activity" RELATED [EC:3.2.1.101]
synonym: "1,6-beta-D-mannan mannanohydrolase activity" RELATED [EC:3.2.1.101]
synonym: "endo-1,6-beta-mannanase activity" RELATED [EC:3.2.1.101]
synonym: "endo-alpha-1->6-D-mannanase activity" RELATED [EC:3.2.1.101]
synonym: "endo-alpha-D-mannosidase activity" EXACT []
synonym: "exo-1,6-beta-mannanase activity" RELATED [EC:3.2.1.101]
synonym: "mannan endo-1,6-beta-mannosidase activity" RELATED [EC:3.2.1.101]
xref: EC:3.2.1.101
xref: MetaCyc:3.2.1.101-RXN
xref: Reactome:R-HSA-6799581 "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man"
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0008498
name: obsolete phospholipid scrambling
namespace: molecular_function
def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "phospholipid scrambling" EXACT []
is_obsolete: true
replaced_by: GO:0017121

[Term]
id: GO:0008499
name: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H+ + UDP." [PMID:10212226, RHEA:53432]
synonym: "beta-1,3-GalTase activity" BROAD []
synonym: "beta3Gal-Ts activity" BROAD []
synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT []
xref: EC:2.4.1.86
xref: MetaCyc:2.4.1.86-RXN
xref: Reactome:R-HSA-914010 "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein"
xref: Reactome:R-HSA-9603989 "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain"
xref: Reactome:R-HSA-9845516 "B3GALT4 transfers Gal to gangliosides"
xref: RHEA:53432
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0008500
name: obsolete glycine-, glutamate-, thienylcyclohexylpiperidine binding
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a conglomeration of three terms.
synonym: "glycine-, glutamate-, thienylcyclohexylpiperidine binding" EXACT []
is_obsolete: true
consider: GO:0016594
consider: GO:0016595
consider: GO:0016596

[Term]
id: GO:0008502
name: melatonin receptor activity
namespace: molecular_function
def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0008503
name: benzodiazepine receptor activity
namespace: molecular_function
def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0008504
name: monoamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015201
def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah]
xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles"
xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles"
xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse"
xref: Reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines"
xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol"
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0008506
name: sucrose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3]
synonym: "hydrogen/sucrose transporter activity" BROAD []
synonym: "sucrose:hydrogen symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-244
xref: RHEA:72187
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0009669 ! sucrose:monoatomic cation symporter activity

[Term]
id: GO:0008507
name: sodium:iodide symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1]
synonym: "sodium/iodide symporter activity" EXACT []
xref: Reactome:R-HSA-429591 "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol"
xref: Reactome:R-HSA-5658195 "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol"
is_a: GO:0015111 ! iodide transmembrane transporter activity
is_a: GO:0015373 ! monoatomic anion:sodium symporter activity

[Term]
id: GO:0008508
name: bile acid:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-]
synonym: "sodium/bile acid symporter activity" EXACT []
xref: Reactome:R-HSA-194121 "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-194187 "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-433089 "SOAT can transport taurolithocholate-3-sulphate"
is_a: GO:0015125 ! bile acid transmembrane transporter activity
is_a: GO:0140161 ! monocarboxylate:sodium symporter activity

[Term]
id: GO:0008509
name: monoatomic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
synonym: "anion transmembrane transporter activity" BROAD []
synonym: "anion transporter activity" EXACT []
xref: Reactome:R-HSA-166214 "FA anion flip-flops to the opposite surface"
is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity

[Term]
id: GO:0008510
name: sodium:bicarbonate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1]
synonym: "sodium/bicarbonate cotransporter activity" BROAD []
synonym: "sodium:bicarbonate cotransporter activity" BROAD []
synonym: "sodium:hydrogencarbonate symporter activity" EXACT []
xref: Reactome:R-HSA-425483 "SLC4A5,7,9 cotransport Na+ with 3HCO3-"
xref: Reactome:R-HSA-5656219 "Defective SLC4A4 does not cotransport Na+ with 3HCO3-"
xref: Reactome:R-HSA-8878664 "SLC4A4 cotransports Na+ with 3HCO3-"
xref: RHEA:70267
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0140410 ! monoatomic cation:bicarbonate symporter activity

[Term]
id: GO:0008511
name: sodium:potassium:chloride symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1]
synonym: "sodium/potassium/chloride symporter activity" EXACT []
xref: Reactome:R-HSA-426086 "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol"
xref: Reactome:R-HSA-5623588 "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol"
xref: RHEA:72395
is_a: GO:0009674 ! potassium:sodium symporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity
is_a: GO:0015379 ! potassium:chloride symporter activity

[Term]
id: GO:0008512
name: sulfate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-]
synonym: "sulfate/hydrogen symporter activity" EXACT []
synonym: "sulfate:hydrogen symporter activity" EXACT []
synonym: "sulphate:hydrogen symporter activity" EXACT []
xref: RHEA:28574
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0008513
name: secondary active organic cation transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015354
def: "Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:curators]
synonym: "organic cation porter activity" RELATED []
synonym: "polyspecific organic cation transmembrane transporter activity" NARROW []
xref: Reactome:R-HSA-549241 "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008514
name: organic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]
xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5"
xref: Reactome:R-HSA-561041 "OAT1-3 transport organic anions with antiport of dicarboxylic acids"
xref: Reactome:R-HSA-9794830 "SLC22A8 transports Cipro into renal cell"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0008515
name: sucrose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019188
def: "Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "sucrose permease (PTS) activity" EXACT []
synonym: "sucrose permease activity" RELATED []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0008516
name: hexose uniporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5]
is_a: GO:0015149 ! hexose transmembrane transporter activity
is_a: GO:0015292 ! uniporter activity

[Term]
id: GO:0008517
name: folic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai]
synonym: "folate transmembrane transporter activity" EXACT []
synonym: "folate transporter activity" EXACT []
synonym: "folic acid transporter activity" RELATED []
synonym: "vitamin B9 transporter activity" EXACT []
synonym: "vitamin M transporter activity" EXACT []
xref: Reactome:R-HSA-200646 "Cytosolic folate export across the plasma membrane"
xref: Reactome:R-HSA-200652 "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol"
xref: Reactome:R-HSA-200680 "SLC25A32 transports THF from cytosol to mitochondrial matrix"
xref: Reactome:R-HSA-200720 "SLC25A32 transports THF from mitochondrial matrix to cytosol"
xref: Reactome:R-HSA-200729 "SLC46A1 transports FOLA from extracellular region to cytosol"
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0008518
name: folate:monoatomic anion antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF." [GOC:mtg_transport, PMID:21568705, PMID:24745983, TC:2.A.48]
synonym: "folate:anion antiporter activity" BROAD []
synonym: "reduced folate carrier activity" RELATED []
synonym: "reduced folate transmembrane transporter activity" RELATED []
synonym: "reduced folate transporter" RELATED []
xref: TC:2.A.48
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0008517 ! folic acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0008519
name: ammonium channel activity
namespace: molecular_function
alt_id: GO:0015251
alt_id: GO:0051739
def: "Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel." [PMID:17710640]
synonym: "ammonia transmembrane transporter activity" BROAD []
synonym: "ammonium transmembrane transporter activity" BROAD []
xref: MetaCyc:RXN-9615
xref: Reactome:R-HSA-444393 "RhCG mediates ammonium influx into kidney collecting duct cells"
xref: Reactome:R-HSA-444416 "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)"
xref: Reactome:R-HSA-444419 "RhBG mediates ammonium effflux out of kidney collecting duct cells"
xref: Reactome:R-HSA-446277 "RhCG mediates ammonium efflux out of kidney collecting duct cells"
xref: Reactome:R-HSA-446278 "RhBG mediates ammonium influx into kidney collecting duct cells"
xref: Reactome:R-HSA-5623051 "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc)"
xref: TC:1.A.11
is_a: GO:0015267 ! channel activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0008520
name: L-ascorbate:sodium symporter activity
namespace: molecular_function
alt_id: GO:0070890
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, GOC:yaf, PMID:18094143]
synonym: "sodium-dependent L-ascorbate transmembrane transporter activity" RELATED []
synonym: "sodium-dependent L-ascorbic acid transporter" RELATED []
xref: RHEA:69883
xref: TC:2.A.40.6.1
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0008521
name: acetyl-CoA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
synonym: "acetyl-CoA transporter activity" RELATED []
xref: Reactome:R-HSA-5649742 "Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen"
xref: Reactome:R-HSA-727759 "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0008523
name: sodium-dependent multivitamin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2]
xref: Reactome:R-HSA-199206 "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol"
xref: Reactome:R-HSA-199219 "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol"
xref: Reactome:R-HSA-429581 "SLC5A6 transports vitamins from extracellular region to cytosol"
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0008525
name: phosphatidylcholine transporter activity
namespace: molecular_function
def: "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]
synonym: "phosphatidylcholine transmembrane transporter activity" NARROW [GOC:bf, GOC:vw]
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0008526
name: phosphatidylinositol transfer activity
namespace: molecular_function
alt_id: GO:0120018
def: "Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "intermembrane phosphatidylinositol transfer activity" NARROW []
synonym: "intermembrane phosphotidylinositol transfer activity" NARROW []
synonym: "phosphatidylinositol carrier activity" EXACT []
synonym: "phosphatidylinositol transporter activity" BROAD []
xref: Reactome:R-HSA-1483229 "PI:PITPNB is transported from the ER membrane to the Golgi membrane"
xref: Reactome:R-HSA-8869241 "PITPNM1,2,3 exchange PI for PA"
xref: Reactome:R-HSA-8874470 "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane"
is_a: GO:0120014 ! phospholipid transfer activity

[Term]
id: GO:0008527
name: taste receptor activity
namespace: molecular_function
def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
synonym: "gustatory receptor" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0008528
name: G protein-coupled peptide receptor activity
namespace: molecular_function
def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]
synonym: "G protein coupled peptide receptor activity" EXACT []
synonym: "G-protein coupled peptide receptor activity" EXACT []
synonym: "peptide receptor activity, G protein coupled" EXACT []
synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0001653 ! peptide receptor activity
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0008529
name: obsolete endogenous peptide receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "endogenous peptide receptor activity" EXACT []
is_obsolete: true
consider: GO:0001653
consider: GO:0005622

[Term]
id: GO:0008530
name: obsolete exogenous peptide receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "exogenous peptide receptor activity" EXACT []
is_obsolete: true
consider: GO:0001653
consider: GO:0005576

[Term]
id: GO:0008531
name: riboflavin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+." [EC:2.7.1.26, RHEA:14357]
synonym: "ATP:riboflavin 5'-phosphotransferase activity" RELATED [EC:2.7.1.26]
synonym: "FK" RELATED [EC:2.7.1.26]
synonym: "flavokinase activity" RELATED [EC:2.7.1.26]
synonym: "riboflavin kinase (phosphorylating)" RELATED [EC:2.7.1.26]
synonym: "riboflavine kinase activity" RELATED [EC:2.7.1.26]
xref: EC:2.7.1.26
xref: KEGG_REACTION:R00549
xref: MetaCyc:RIBOFLAVINKIN-RXN
xref: Reactome:R-HSA-196964 "RFK:Mg2+ phosphorylates RIB"
xref: RHEA:14357
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008532
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H+ + UDP." [RHEA:14389]
synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149]
synonym: "GnTE activity" RELATED [EC:2.4.1.149]
synonym: "N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149]
synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149]
synonym: "UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149]
synonym: "UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149]
synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.149]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149]
xref: EC:2.4.1.149
xref: MetaCyc:2.4.1.149-RXN
xref: Reactome:R-HSA-2025724 "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG"
xref: RHEA:14389
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008533
name: obsolete astacin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "astacin activity" EXACT []
synonym: "Astacus proteinase activity" RELATED []
synonym: "astacus proteinase activity" NARROW []
synonym: "crayfish small-molecule proteinase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008534
name: oxidized purine nucleobase lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0003907
def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" RELATED [EC:3.2.2.23]
synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" RELATED [EC:3.2.2.23]
synonym: "8-oxoguanine DNA glycosylase activity" BROAD []
synonym: "bifunctional DNA glycosylase activity" BROAD []
synonym: "deoxyribonucleate glycosidase activity" RELATED [EC:3.2.2.23]
synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23]
synonym: "DNA glycosylase/AP-lyase activity" BROAD []
synonym: "DNA glycosylase/beta-lyase activity" BROAD []
synonym: "DNA-formamidopyrimidine glycosylase activity" RELATED []
synonym: "Fapy-DNA glycosylase activity" RELATED [EC:3.2.2.23]
synonym: "formamidopyrimidine-DNA glycosylase activity" RELATED []
synonym: "Fpg protein" RELATED [EC:3.2.2.23]
synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT []
synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: EC:3.2.2.23
xref: MetaCyc:3.2.2.23-RXN
xref: Reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase"
xref: Reactome:R-HSA-110243 "Excision of 8-oxoguanine by OGG1 glycosylase"
xref: Reactome:R-HSA-110244 "Excision of FapyG by OGG1 glycosylase"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity

[Term]
id: GO:0008535
name: respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, PMID:32311046]
synonym: "cytochrome c oxidase biogenesis" BROAD []
synonym: "cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0008537
name: proteasome activator complex
namespace: cellular_component
def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb]
synonym: "PA28" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0008538
name: obsolete proteasome activator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771]
comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
synonym: "PA28" NARROW []
synonym: "proteasome activator activity" EXACT []
is_obsolete: true
consider: GO:0061133
consider: GO:0061136

[Term]
id: GO:0008539
name: obsolete proteasome inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah]
comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
synonym: "PI-31" NARROW []
synonym: "proteasome inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004866
consider: GO:0061136

[Term]
id: GO:0008540
name: proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005838 ! proteasome regulatory particle

[Term]
id: GO:0008541
name: proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005838 ! proteasome regulatory particle

[Term]
id: GO:0008542
name: visual learning
namespace: biological_process
def: "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089]
synonym: "spatial learning" RELATED []
is_a: GO:0007632 ! visual behavior
is_a: GO:0008306 ! associative learning

[Term]
id: GO:0008543
name: fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "FGF receptor signaling pathway" EXACT []
synonym: "FGF receptor signalling pathway" EXACT []
synonym: "FGFR signaling pathway" EXACT []
synonym: "fibroblast growth factor receptor signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus

[Term]
id: GO:0008544
name: epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0008545
name: JUN kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549]
synonym: "JNKK" EXACT []
xref: Reactome:R-HSA-168162 "Phosphorylation of human JNKs by activated MKK4/MKK7"
is_a: GO:0004708 ! MAP kinase kinase activity

[Term]
id: GO:0008546
name: obsolete microtubule/chromatin interaction
namespace: biological_process
def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137]
comment: This term was made obsolete because it represents a molecular function.
synonym: "microtubule/chromatin interaction" EXACT []
is_obsolete: true
consider: GO:0003677
consider: GO:0003682
consider: GO:0008017
consider: GO:0030674

[Term]
id: GO:0008547
name: obsolete protein-synthesizing GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "protein-synthesizing GTPase activity" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0006412
consider: GO:0008135

[Term]
id: GO:0008548
name: obsolete signal-recognition-particle GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "signal-recognition-particle GTPase activity" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005786

[Term]
id: GO:0008549
name: obsolete dynamin GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "dynamin GTPase activity" EXACT []
synonym: "dynamine GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0006897

[Term]
id: GO:0008550
name: obsolete tubulin GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "tubulin GTPase activity" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0007021

[Term]
id: GO:0008551
name: P-type cadmium transporter activity
namespace: molecular_function
alt_id: GO:0008561
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)." [PMID:17326661]
synonym: "cadmium exporting ATPase activity" EXACT []
synonym: "cadmium transmembrane transporter activity, phosphorylative mechanism" RELATED []
synonym: "cadmium-exporting ATPase activity" NARROW []
synonym: "cadmium-translocating P-type ATPase activity" EXACT [EC:7.2.2.21]
synonym: "Cd(2+)-exporting ATPase activity" RELATED [EC:7.2.2.21]
synonym: "Cd2+-exporting ATPase activity" RELATED [EC:7.2.2.21]
xref: EC:7.2.2.21
xref: MetaCyc:3.6.3.3-RXN
xref: RHEA:12132
is_a: GO:0015086 ! cadmium ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0008552
name: obsolete zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" EXACT []
is_obsolete: true
consider: GO:0005385
consider: GO:0015086
consider: GO:0015087
consider: GO:0015094
consider: GO:0015099
consider: GO:0015662

[Term]
id: GO:0008553
name: P-type proton-exporting transporter activity
namespace: molecular_function
alt_id: GO:0036442
def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [RHEA:20852]
synonym: "H+-exporting ATPase activity" RELATED [EC:7.1.2.1]
synonym: "H+-transporting ATPase" BROAD [EC:7.1.2.1]
synonym: "H+-transporting ATPase activity" BROAD [EC:7.1.2.1]
synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT []
synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED []
synonym: "hydrogen-exporting ATPase activity" BROAD []
synonym: "hydrogen-exporting ATPase activity, phosphorylative mechanism" RELATED []
synonym: "P-type H+-exporting ATPase activity" BROAD [EC:7.1.2.1]
synonym: "proton transport ATPase activity" RELATED [EC:7.1.2.1]
synonym: "proton-exporting ATPase activity" BROAD []
synonym: "proton-exporting ATPase activity, phosphorylative mechanism" RELATED []
synonym: "proton-translocating ATPase activity" RELATED [EC:7.1.2.1]
synonym: "proton-transporting ATPase activity" EXACT [GOC:bf]
xref: EC:7.1.2.1
xref: MetaCyc:3.6.3.6-RXN
xref: RHEA:20852
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0008554
name: P-type sodium transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism." [PMID:9224683]
comment: Note that RHEA:14633 represents both the ABC and the P-type sodium transporters.
synonym: "Na(+)-exporting ATPase activity" BROAD [EC:7.2.2.3]
synonym: "Na(+)-transporting ATPase activity" BROAD [EC:7.2.2.3]
synonym: "Na+-exporting ATPase activity" BROAD [EC:7.2.2.3]
synonym: "Na+-transporting ATPase activity" BROAD [EC:7.2.2.3]
synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT []
synonym: "sodium transmembrane transporter activity, phosphorylative mechanism" EXACT []
synonym: "sodium transport ATPase activity" BROAD [EC:7.2.2.3]
synonym: "sodium-exporting ATPase activity" BROAD [EC:7.2.2.3]
synonym: "sodium-exporting ATPase activity, phosphorylative mechanism" EXACT []
synonym: "sodium-translocating P-type ATPase activity" EXACT [EC:7.2.2.3]
xref: EC:7.2.2.3
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0008556
name: P-type potassium transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015618
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [RHEA:16777]
synonym: "ATP phosphohydrolase (K+-importing)" RELATED [EC:7.2.2.6]
synonym: "ATP-dependent potassium transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled potassium transmembrane transporter activity" RELATED []
synonym: "K(+)-importing ATPase activity" NARROW [EC:7.2.2.6]
synonym: "K(+)-transporting ATPase activity" RELATED [EC:7.2.2.6]
synonym: "K+-importing ATPase activity" RELATED [EC:7.2.2.6]
synonym: "K+-transporting ATPase activity" EXACT []
synonym: "potassium ABC transporter" NARROW []
synonym: "potassium transmembrane transporter activity, phosphorylative mechanism" EXACT []
synonym: "potassium transporting ATPase activity" EXACT []
synonym: "potassium-importing ATPase activity" NARROW [EC:7.2.2.6]
synonym: "potassium-transporting ATPase activity" EXACT []
synonym: "potassium-uptake-ATPase activity" EXACT []
xref: EC:7.2.2.6
xref: MetaCyc:TRANS-RXN-2
xref: RHEA:16777
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0008558
name: ABC-type guanine transporter activity
namespace: molecular_function
def: "Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [RHEA:20832]
synonym: "ATP-dependent guanine transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled guanine transmembrane transporter activity" RELATED []
synonym: "guanine ABC transporter" EXACT []
synonym: "guanine-transporting ATPase activity" RELATED [EC:7.6.2.6]
xref: EC:7.6.2.6
xref: MetaCyc:3.6.3.37-RXN
xref: RHEA:20832
is_a: GO:0015208 ! guanine transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0008559
name: ABC-type xenobiotic transporter activity
namespace: molecular_function
alt_id: GO:0005226
alt_id: GO:0008560
def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]
synonym: "ATP phosphohydrolase (xenobiotic-exporting)" RELATED [EC:7.6.2.2]
synonym: "ATP-dependent xenobiotic transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled xenobiotic transmembrane transporter activity" RELATED []
synonym: "MDR protein" RELATED [EC:7.6.2.2]
synonym: "multidrug resistance exporter" RELATED []
synonym: "multidrug-resistance protein" RELATED []
synonym: "P-glycoprotein" RELATED [EC:7.6.2.2]
synonym: "PDR protein" RELATED [EC:7.6.2.2]
synonym: "pleiotropic-drug-resistance protein" RELATED [EC:7.6.2.2]
synonym: "xenobiotic ABC transporter" NARROW []
synonym: "xenobiotic transmembrane transporting ATPase activity" EXACT []
xref: EC:7.6.2.2
xref: MetaCyc:3.6.3.44-RXN
xref: Reactome:R-HSA-9757139 "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region"
is_a: GO:0042910 ! xenobiotic transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0008563
name: obsolete alpha-factor sex pheromone exporter
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48]
comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported.
synonym: "alpha-factor sex pheromone exporter" EXACT []
synonym: "alpha-factor-transporting ATPase" RELATED []
is_obsolete: true

[Term]
id: GO:0008564
name: protein-exporting ATPase activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins." [PMID:30346996]
comment: Represents ATP- hydrolyzing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eukaryotes, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex.
synonym: "ATPase-coupled protein transporter activity" EXACT []
xref: EC:7.4.2.8
xref: MetaCyc:3.6.3.50-RXN
is_a: GO:0015450 ! protein-transporting ATPase activity

[Term]
id: GO:0008565
name: obsolete protein transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
comment: This term was obsoleted because is has been inconsistently used.
synonym: "enzyme transporter activity" NARROW []
synonym: "holin" RELATED []
synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "secretin" RELATED []
is_obsolete: true

[Term]
id: GO:0008566
name: mitochondrial protein-transporting ATPase activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:7.4.2.3]
comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'.
synonym: "ATPase-coupled mitochondrial protein transporter activity" EXACT []
xref: EC:7.4.2.3
xref: MetaCyc:3.6.3.51-RXN
is_a: GO:0015450 ! protein-transporting ATPase activity

[Term]
id: GO:0008567
name: obsolete dynein ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "dynein ATPase activity" EXACT []
is_obsolete: true
consider: GO:0003777
consider: GO:0007018

[Term]
id: GO:0008568
name: microtubule severing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [PMID:10910766]
comment: See also the cellular component term 'katanin complex ; GO:0008352'.
synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT []
synonym: "katanin activity" NARROW [EC:5.6.1.1]
synonym: "microtubule-severing ATPase activity" EXACT []
xref: EC:5.6.1.1
xref: MetaCyc:3.6.4.3-RXN
xref: Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites"
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0140657 ! ATP-dependent activity
is_a: GO:0170060 ! microtubule destablizing activity

[Term]
id: GO:0008569
name: minus-end-directed microtubule motor activity
namespace: molecular_function
def: "A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis." [GOC:mah, GOC:vw, PMID:15659646, PMID:32842864]
synonym: "ATP-dependent microtubule motor activity, minus-end-directed" EXACT []
synonym: "ATP-dependent minus-end-directed microtubule motor activity" EXACT []
synonym: "dynein ATPase" NARROW []
synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" NARROW []
synonym: "microtubule motor activity, minus-end-directed" EXACT []
synonym: "minus-end-directed ATP-dependent microtubule motor activity" EXACT []
synonym: "minus-end-directed kinesin ATPase activity" NARROW []
is_a: GO:0003777 ! microtubule motor activity

[Term]
id: GO:0008570
name: obsolete myosin ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "myosin ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0000146
consider: GO:0030048

[Term]
id: GO:0008571
name: obsolete non-chaperonin molecular chaperone ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "non-chaperonin molecular chaperone ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016887
consider: GO:0006457

[Term]
id: GO:0008572
name: obsolete nucleoplasmin ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "nucleoplasmin ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016887

[Term]
id: GO:0008573
name: obsolete peroxisome-assembly ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7]
comment: This term was made obsolete because it incorporates process information.
synonym: "peroxisome-assembly ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016887
consider: GO:0007031

[Term]
id: GO:0008574
name: plus-end-directed microtubule motor activity
namespace: molecular_function
def: "A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis." [GOC:vw, PMID:32842864]
synonym: "ATP-dependent microtubule motor activity, plus-end-directed" EXACT []
synonym: "ATP-dependent plus-end-directed microtubule motor activity" EXACT []
synonym: "kinesin activity" RELATED [EC:5.6.1.3]
synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" NARROW []
synonym: "microtubule motor activity, plus-end-directed" EXACT []
synonym: "plus-end-directed ATP-dependent microtubule motor activity" EXACT []
synonym: "plus-end-directed kinesin ATPase activity" NARROW []
xref: EC:5.6.1.3
xref: MetaCyc:3.6.4.4-RXN
is_a: GO:0003777 ! microtubule motor activity

[Term]
id: GO:0008575
name: obsolete proteasome ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8]
comment: This term was made obsolete because it mentions a component term in the term text string.
synonym: "proteasome ATPase activity" EXACT []
is_obsolete: true
consider: GO:0016887

[Term]
id: GO:0008576
name: obsolete vesicle-fusing ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6]
comment: This term was made obsolete because it incorporates process information.
synonym: "vesicle-fusing ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016887
consider: GO:0016192
consider: GO:0061025

[Term]
id: GO:0008579
name: JUN kinase phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah]
is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity

[Term]
id: GO:0008580
name: obsolete cytoskeletal regulator activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology.
synonym: "cytoskeletal regulator activity" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0008581
name: obsolete ubiquitin-specific protease 5 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001]
comment: This term was made obsolete because it represents a gene product.
synonym: "ubiquitin isopeptidase T activity" EXACT []
synonym: "ubiquitin-specific protease 5 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004843

[Term]
id: GO:0008582
name: regulation of synaptic assembly at neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions." [GOC:go_curators]
synonym: "regulation of synaptic growth at neuromuscular junction" RELATED []
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1904396 ! regulation of neuromuscular junction development
relationship: regulates GO:0051124 ! synaptic assembly at neuromuscular junction

[Term]
id: GO:0008583
name: mystery cell differentiation
namespace: biological_process
def: "The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0008584
name: male gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid]
synonym: "testicular development" EXACT [GOC:sl]
synonym: "testis development" EXACT [GOC:sl]
is_a: GO:0008406 ! gonad development
relationship: part_of GO:0046546 ! development of primary male sexual characteristics

[Term]
id: GO:0008585
name: female gonad development
namespace: biological_process
alt_id: GO:0061039
def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
synonym: "ovarian development" RELATED [GOC:sl]
synonym: "ovary development" RELATED [GOC:sl]
is_a: GO:0008406 ! gonad development
relationship: part_of GO:0046545 ! development of primary female sexual characteristics

[Term]
id: GO:0008586
name: imaginal disc-derived wing vein morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
synonym: "wing vein morphogenesis" EXACT []
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0008587
name: imaginal disc-derived wing margin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'.
synonym: "wing margin morphogenesis" EXACT []
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0008589
name: regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0007226
alt_id: GO:0043109
def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "regulation of smoothened activity" RELATED []
synonym: "regulation of smoothened by patched" RELATED []
synonym: "regulation of smoothened receptor activity by patched" RELATED []
synonym: "regulation of smoothened signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0008591
name: regulation of Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of frizzled-2 signaling pathway" EXACT []
synonym: "regulation of frizzled-2 signalling pathway" EXACT []
synonym: "regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
relationship: regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway

[Term]
id: GO:0008592
name: regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "regulation of Tl signaling pathway" EXACT []
synonym: "regulation of Tl signalling pathway" EXACT []
synonym: "regulation of Toll signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0008593
name: regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "regulation of N signaling pathway" EXACT []
synonym: "regulation of N signalling pathway" EXACT []
synonym: "regulation of Notch signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0008594
name: photoreceptor cell morphogenesis
namespace: biological_process
def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
synonym: "photoreceptor development" RELATED []
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042461 ! photoreceptor cell development

[Term]
id: GO:0008595
name: anterior/posterior axis specification, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0007351 ! tripartite regional subdivision

[Term]
id: GO:0008597
name: calcium-dependent protein serine/threonine phosphatase regulator activity
namespace: molecular_function
def: "Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [GOC:ai]
synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW []
xref: Reactome:R-HSA-139906 "Activation of BAD by calcineurin"
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0008603
name: cAMP-dependent protein kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT []
synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW []
synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT []
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0008605
name: obsolete protein kinase CK2 regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "casein kinase II, regulator" EXACT []
synonym: "protein kinase CK2 regulator activity" EXACT []
synonym: "protein kinase CK2, intrinsic regulator activity" NARROW []
is_obsolete: true
replaced_by: GO:0019887

[Term]
id: GO:0008607
name: phosphorylase kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme phosphorylase kinase." [GOC:curators]
synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW []
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0008608
name: attachment of spindle microtubules to kinetochore
namespace: biological_process
alt_id: GO:0051313
def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]
comment: This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
synonym: "amphotelic attachment" RELATED []
synonym: "attachment of spindle microtubules to chromosome" EXACT []
synonym: "bipolar attachment" RELATED []
synonym: "kinetochore microtubule interaction" BROAD []
synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "kinetochore-microtubule interaction" BROAD []
synonym: "microtubule anchoring at kinetochore" EXACT []
synonym: "microtubule and chromosome interaction" BROAD []
synonym: "microtubule and kinetochore interaction" RELATED []
synonym: "microtubule capture" NARROW []
synonym: "spindle chromosome attachment" EXACT []
synonym: "spindle kinetochore attachment" EXACT []
synonym: "spindle-chromosome interaction" BROAD []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051310 ! metaphase chromosome alignment

[Term]
id: GO:0008609
name: alkylglycerone-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26]
synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" RELATED [EC:2.5.1.26]
synonym: "alkyl DHAP synthetase activity" RELATED [EC:2.5.1.26]
synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26]
synonym: "alkyl-DHAP synthase activity" RELATED [EC:2.5.1.26]
synonym: "alkyldihydroxyacetone phosphate synthetase activity" RELATED [EC:2.5.1.26]
synonym: "alkyldihydroxyacetonephosphate synthase activity" RELATED [EC:2.5.1.26]
synonym: "DHAP-AT" RELATED [EC:2.5.1.26]
synonym: "dihydroxyacetone-phosphate acyltransferase activity" RELATED [EC:2.5.1.26]
xref: EC:2.5.1.26
xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN
xref: Reactome:R-HSA-390427 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate"
xref: RHEA:36171
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008610
name: lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
synonym: "lipid anabolism" EXACT []
synonym: "lipid biosynthesis" EXACT []
synonym: "lipid formation" EXACT []
synonym: "lipid synthesis" EXACT []
synonym: "lipogenesis" EXACT [GOC:sl]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0008611
name: ether lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120]
synonym: "ether lipid anabolism" EXACT []
synonym: "ether lipid biosynthesis" EXACT []
synonym: "ether lipid formation" EXACT []
synonym: "ether lipid synthesis" EXACT []
synonym: "plasmalogen biosynthetic process" NARROW []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0046485 ! ether lipid metabolic process
is_a: GO:0046504 ! glycerol ether biosynthetic process

[Term]
id: GO:0008612
name: peptidyl-lysine modification to peptidyl-hypusine
namespace: biological_process
alt_id: GO:0046515
def: "The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]
subset: gocheck_obsoletion_candidate
synonym: "hypusine anabolism" EXACT []
synonym: "hypusine anabolism from peptidyl-lysine" EXACT []
synonym: "hypusine biosynthesis" EXACT []
synonym: "hypusine biosynthetic process" EXACT []
synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT []
synonym: "hypusine formation" EXACT []
synonym: "hypusine formation from peptidyl-lysine" EXACT []
synonym: "hypusine synthesis" EXACT []
synonym: "hypusine synthesis from peptidyl-lysine" EXACT []
synonym: "hypusinylation" EXACT []
synonym: "protein hypusination" EXACT []
xref: RESID:AA0116
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0008613
name: diuretic hormone activity
namespace: molecular_function
def: "The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0008614
name: pyridoxine metabolic process
namespace: biological_process
alt_id: GO:0006773
def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:curators]
synonym: "pyridoxine metabolism" EXACT []
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0008615
name: pyridoxine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai]
synonym: "pyridoxine anabolism" EXACT []
synonym: "pyridoxine biosynthesis" EXACT []
synonym: "pyridoxine formation" EXACT []
synonym: "pyridoxine synthesis" EXACT []
is_a: GO:0008614 ! pyridoxine metabolic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0008616
name: queuosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732]
synonym: "queuosine anabolism" EXACT []
synonym: "queuosine biosynthesis" EXACT []
synonym: "queuosine formation" EXACT []
synonym: "queuosine synthesis" EXACT []
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046116 ! queuosine metabolic process

[Term]
id: GO:0008617
name: guanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732]
synonym: "guanosine metabolism" EXACT []
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0008618
name: 7-methylguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732]
synonym: "7-methylguanosine metabolism" EXACT []
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0008619
name: obsolete RHEB small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813]
comment: This term was made obsolete because it represents a gene product.
synonym: "RHEB small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0001558
consider: GO:0051726

[Term]
id: GO:0008622
name: epsilon DNA polymerase complex
namespace: cellular_component
def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]
synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0008623
name: CHRAC
namespace: cellular_component
alt_id: GO:0016588
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]
synonym: "chromatin accessibility complex" EXACT []
synonym: "ISW2 complex" NARROW []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0008625
name: extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis]
comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
synonym: "death receptor-mediated apoptosis" NARROW []
synonym: "induction of apoptosis via death domain receptors" RELATED []
synonym: "induction of apoptosis via death receptors" EXACT [GOC:mah]
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:0008626
name: granzyme-mediated apoptotic signaling pathway
namespace: biological_process
def: "The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells." [GOC:mtg_apoptosis, PMID:17158907]
synonym: "apoptotic signaling pathway in response to granzyme" RELATED []
synonym: "induction of apoptosis by granzyme" RELATED []
is_a: GO:0097190 ! apoptotic signaling pathway
is_a: GO:0140507 ! granzyme-mediated programmed cell death signaling pathway

[Term]
id: GO:0008627
name: intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:11454444, PMID:16483738]
synonym: "induction of apoptosis by ionic changes" RELATED []
is_a: GO:0071470 ! cellular response to osmotic stress
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0008628
name: hormone-mediated apoptotic signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:mtg_apoptosis]
comment: This term is placed under GO:0097190 apoptotic signaling pathway, rather than under one of its more specific children terms, to cover for the variety of apoptosis signaling mechanisms that different hormones may use.
synonym: "apoptotic signaling pathway in response to hormone" RELATED []
synonym: "induction of apoptosis by hormones" RELATED []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0008630
name: intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "DNA damage response, signal transduction resulting in induction of apoptosis" RELATED []
is_a: GO:0006974 ! DNA damage response
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0008631
name: intrinsic apoptotic signaling pathway in response to oxidative stress
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis]
synonym: "induction of apoptosis by oxidative stress" RELATED []
synonym: "oxidative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0008633
name: obsolete activation of pro-apoptotic gene products
namespace: biological_process
def: "OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because more specific terms were created. Additionally, the meaning of the term is ambiguous (some gene products may be involved in apoptosis, or not, depending on cell type, tissue, condition).
synonym: "activation of pro-apoptotic gene products" EXACT []
synonym: "induction of pro-apoptotic gene products" RELATED []
is_obsolete: true

[Term]
id: GO:0008634
name: obsolete negative regulation of survival gene product expression
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb]
comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc.
synonym: "down regulation of survival gene product activity" BROAD []
synonym: "down-regulation of survival gene product activity" BROAD []
synonym: "downregulation of survival gene product activity" BROAD []
synonym: "inhibition of survival gene product activity" NARROW []
synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "negative regulation of survival gene product expression" EXACT []
synonym: "negative regulation of survival gene products" BROAD []
is_obsolete: true

[Term]
id: GO:0008635
name: obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, Wikipedia:Caspase]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activation of caspase activity by cytochrome c" NARROW []
synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:2001056

[Term]
id: GO:0008636
name: obsolete activation of caspase activity by protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Upregulation of the activity of a caspase, a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase]
comment: This term was made obsolete because it is ill-defined: phosphorylation regulates the activity of caspases, but it doesn't activate them (caspases are only activated upon cleavage).
synonym: "activation of caspase activity by protein amino acid phosphorylation" EXACT [GOC:bf]
synonym: "activation of caspase activity by protein phosphorylation" EXACT []
synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0008637
name: apoptotic mitochondrial changes
namespace: biological_process
def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.
is_a: GO:0007005 ! mitochondrion organization
relationship: part_of GO:0006915 ! apoptotic process

[Term]
id: GO:0008638
name: obsolete protein tagging activity
namespace: molecular_function
def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl]
comment: This term was made obsolete because it represents a biological process and a molecular function.
synonym: "protein tagging activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0031386
consider: GO:0036211

[Term]
id: GO:0008641
name: ubiquitin-like modifier activating enzyme activity
namespace: molecular_function
alt_id: GO:0008642
def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "small protein activating enzyme activity" NARROW []
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0008643
name: carbohydrate transport
namespace: biological_process
alt_id: GO:0006861
alt_id: GO:0008644
def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
synonym: "sugar transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0008645
name: hexose transmembrane transport
namespace: biological_process
alt_id: GO:0008646
alt_id: GO:0008647
alt_id: GO:0035428
def: "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "hexose membrane transport" RELATED []
synonym: "hexose transport" RELATED []
synonym: "high-affinity hexose transport" NARROW []
synonym: "low-affinity hexose transport" NARROW []
is_a: GO:0015749 ! monosaccharide transmembrane transport

[Term]
id: GO:0008648
name: obsolete tachykinin
namespace: molecular_function
def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
synonym: "tachykinin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0042311
consider: GO:0045987
consider: GO:0046878

[Term]
id: GO:0008649
name: rRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0140102 ! catalytic activity, acting on a rRNA

[Term]
id: GO:0008650
name: rRNA (uridine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah]
xref: Reactome:R-HSA-6793127 "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine"
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity
is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity

[Term]
id: GO:0008651
name: obsolete actin polymerizing activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "actin polymerizing activity" EXACT []
is_obsolete: true
consider: GO:0030041
consider: GO:0042802

[Term]
id: GO:0008652
name: amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]
synonym: "amino acid anabolism" EXACT []
synonym: "amino acid biosynthesis" EXACT []
synonym: "amino acid formation" EXACT []
synonym: "amino acid synthesis" EXACT []
synonym: "cellular amino acid biosynthetic process" EXACT []
xref: Wikipedia:Amino_acid_synthesis
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0008653
name: lipopolysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732]
synonym: "lipopolysaccharide metabolism" EXACT []
synonym: "LPS metabolic process" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1903509 ! liposaccharide metabolic process

[Term]
id: GO:0008654
name: phospholipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
synonym: "phospholipid anabolism" EXACT []
synonym: "phospholipid biosynthesis" EXACT []
synonym: "phospholipid formation" EXACT []
synonym: "phospholipid synthesis" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0008655
name: pyrimidine-containing compound salvage
namespace: biological_process
def: "Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [GOC:jl]
subset: goslim_pir
synonym: "pyrimidine salvage" RELATED []
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0008656
name: cysteine-type endopeptidase activator activity involved in apoptotic process
namespace: molecular_function
def: "Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
comment: Examples of this are 1) granzymes that may bind to initiator caspases and cleave them, and 2) already active caspases, e.g. caspase 9, that cleave effector caspases.
synonym: "caspase activator activity" BROAD []
xref: Reactome:R-HSA-205117 "p75NTR:NADE promotes caspase2/3 activation"
xref: Reactome:R-HSA-449073 "Caspase-3 cleaves pro-interleukin-16"
is_a: GO:0016505 ! peptidase activator activity involved in apoptotic process
is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process

[Term]
id: GO:0008657
name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0042030 ! ATPase inhibitor activity
is_a: GO:0072586 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity

[Term]
id: GO:0008658
name: penicillin binding
namespace: molecular_function
def: "Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai]
subset: goslim_metagenomics
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0008659
name: obsolete (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [GOC:ai, PMID:12368867]
comment: This term was obsoleted because it represents a specific substrate of (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity ; GO:0019171.
synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity" EXACT []
synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT []
is_obsolete: true
replaced_by: GO:0019171

[Term]
id: GO:0008660
name: 1-aminocyclopropane-1-carboxylate deaminase activity
namespace: molecular_function
alt_id: GO:0018806
def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanate + NH4." [RHEA:16933]
synonym: "1-aminocyclopropane carboxylic acid deaminase activity" RELATED [EC:3.5.99.7]
synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" RELATED [EC:3.5.99.7]
synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" RELATED [EC:3.5.99.7]
synonym: "ACC deaminase activity" RELATED [EC:3.5.99.7]
xref: EC:3.5.99.7
xref: KEGG_REACTION:R00997
xref: MetaCyc:4.1.99.4-RXN
xref: RHEA:16933
xref: UM-BBD_reactionID:r0357
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008661
name: 1-deoxy-D-xylulose-5-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2." [EC:2.2.1.7, RHEA:12605]
synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT []
synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT []
synonym: "DOXP synthase activity" EXACT []
synonym: "DXP-synthase activity" EXACT []
synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" RELATED [EC:2.2.1.7]
xref: EC:2.2.1.7
xref: KEGG_REACTION:R05636
xref: MetaCyc:DXS-RXN
xref: RHEA:12605
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0008662
name: 1-phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56]
synonym: "1-phosphofructokinase (phosphorylating)" RELATED [EC:2.7.1.56]
synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.56]
synonym: "D-fructose-1-phosphate kinase activity" RELATED [EC:2.7.1.56]
synonym: "fructose 1-phosphate kinase activity" RELATED [EC:2.7.1.56]
synonym: "fructose-1-phosphate kinase activity" RELATED [EC:2.7.1.56]
synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56]
xref: EC:2.7.1.56
xref: MetaCyc:1PFRUCTPHOSN-RXN
xref: RHEA:14213
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0008663
name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16]
synonym: "2',3 '-cyclic AMP phosphodiesterase activity" RELATED [EC:3.1.4.16]
synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" RELATED [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleotidase activity" RELATED [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16]
synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" RELATED [EC:3.1.4.16]
synonym: "2':3'-cyclic phosphodiesterase activity" RELATED [EC:3.1.4.16]
synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" RELATED [EC:3.1.4.16]
synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16]
synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" RELATED [EC:3.1.4.16]
synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" RELATED [EC:3.1.4.16]
synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" RELATED [EC:3.1.4.16]
xref: EC:3.1.4.16
xref: MetaCyc:CYCPHOSDIESTER-RXN
xref: RHEA:19621
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0008664
name: RNA 2',3'-cyclic 3'-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H+." [PMID:25239919, RHEA:11828]
synonym: "2'-5' RNA ligase activity" NARROW []
xref: EC:3.1.4.58
xref: RHEA:11828
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0008666
name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA." [EC:2.3.1.117, RHEA:17325]
synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" RELATED [EC:2.3.1.117]
synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" RELATED [EC:2.3.1.117]
synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" RELATED [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate N-succinyltransferase activity" RELATED [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate succinylase activity" RELATED [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate succinyltransferase activity" RELATED [EC:2.3.1.117]
synonym: "tetrahydropicolinate succinylase activity" RELATED [EC:2.3.1.117]
synonym: "THDP N-succinyltransferase activity" EXACT [PMID:19394346]
xref: EC:2.3.1.117
xref: KEGG_REACTION:R04365
xref: MetaCyc:TETHYDPICSUCC-RXN
xref: RHEA:17325
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0008667
name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH." [EC:1.3.1.28, RHEA:23824]
synonym: "2,3-DHB dehydrogenase activity" RELATED [EC:1.3.1.28]
synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.28]
xref: EC:1.3.1.28
xref: KEGG_REACTION:R01505
xref: MetaCyc:DHBDEHYD-RXN
xref: RHEA:23824
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008668
name: 2,3-dihydroxybenzoate--[aryl-carrier protein] ligase
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP + holo-[ACP] = 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate." [RHEA:61652]
synonym: "(2,3-dihydroxybenzoyl)adenylate synthase activity" NARROW []
synonym: "2,3-dihydroxybenzoate-AMP ligase activity" NARROW []
xref: EC:6.2.1.71
xref: KEGG_REACTION:R12777
xref: MetaCyc:RXN-19445
xref: RHEA:61652
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008670
name: 2,4-dienoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reactions: a 4,5-saturated-(2E)-enoyl-CoA + NADP+ = a (2E,4E)-dienoyl-CoA + H+ + NADPH, and a (2E,4Z)-dienoyl-CoA + H+ + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP+." [EC:1.3.1.34]
synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase (NADPH) activity" RELATED [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase (NADPH2)" RELATED [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase activity" RELATED [EC:1.3.1.34]
synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" RELATED [EC:1.3.1.34]
xref: EC:1.3.1.34
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008671
name: 2-dehydro-3-deoxygalactonokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+." [EC:2.7.1.58, RHEA:16525]
synonym: "2-keto-3-deoxy-galactonokinase activity" RELATED [EC:2.7.1.58]
synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" RELATED [EC:2.7.1.58]
synonym: "2-keto-3-deoxygalactonokinase activity" RELATED [EC:2.7.1.58]
synonym: "2-oxo-3-deoxygalactonate kinase activity" RELATED [EC:2.7.1.58]
synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" RELATED [EC:2.7.1.58]
xref: EC:2.7.1.58
xref: KEGG_REACTION:R03387
xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN
xref: RHEA:16525
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008672
name: 2-dehydro-3-deoxyglucarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20]
synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.20]
synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" RELATED [EC:4.1.2.20]
synonym: "2-keto-3-deoxyglucarate aldolase activity" RELATED [EC:4.1.2.20]
synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" RELATED [EC:4.1.2.20]
xref: EC:4.1.2.20
xref: MetaCyc:4.1.2.20-RXN
xref: RHEA:10268
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008673
name: 2-dehydro-3-deoxygluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+." [EC:2.7.1.45, RHEA:14797]
synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" RELATED [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconate kinase activity" RELATED [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" RELATED [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconokinase activity" RELATED [EC:2.7.1.45]
synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" RELATED [EC:2.7.1.45]
synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.45]
synonym: "KDG kinase activity" RELATED [EC:2.7.1.45]
synonym: "ketodeoxygluconokinase activity" RELATED [EC:2.7.1.45]
xref: EC:2.7.1.45
xref: KEGG_REACTION:R01541
xref: MetaCyc:DEOXYGLUCONOKIN-RXN
xref: RHEA:14797
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008674
name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate." [EC:4.1.2.21, RHEA:24464]
synonym: "(KDPGal)aldolase activity" RELATED [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" RELATED [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" RELATED [EC:4.1.2.21]
synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" RELATED [EC:4.1.2.21]
synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" RELATED [EC:4.1.2.21]
synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" RELATED [EC:4.1.2.21]
synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" RELATED [EC:4.1.2.21]
synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" RELATED [EC:4.1.2.21]
synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" RELATED [EC:4.1.2.21]
xref: EC:4.1.2.21
xref: KEGG_REACTION:R01064
xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN
xref: RHEA:24464
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008675
name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14]
synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" RELATED [EC:4.1.2.14]
synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.14]
synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" RELATED [EC:4.1.2.14]
synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" RELATED [EC:4.1.2.14]
synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" RELATED [EC:4.1.2.14]
synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" RELATED [EC:4.1.2.14]
synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" RELATED [EC:4.1.2.14]
synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" RELATED [EC:4.1.2.14]
synonym: "KDPG aldolase activity" RELATED [EC:4.1.2.14]
synonym: "KDPG-aldolase activity" RELATED [EC:4.1.2.14]
synonym: "ODPG aldolase activity" RELATED [EC:4.1.2.14]
synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" RELATED [EC:4.1.2.14]
synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" RELATED [EC:4.1.2.14]
synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" RELATED [EC:4.1.2.14]
xref: EC:4.1.2.14
xref: MetaCyc:KDPGALDOL-RXN
xref: RHEA:17089
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008676
name: 3-deoxy-8-phosphooctulonate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate." [EC:2.5.1.55, RHEA:14053]
synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.55]
synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" RELATED [EC:2.5.1.55]
synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" RELATED [EC:2.5.1.55]
synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" RELATED [EC:2.5.1.55]
synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" RELATED [EC:2.5.1.55]
synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" RELATED [EC:2.5.1.55]
synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" RELATED [EC:2.5.1.55]
synonym: "KDO-8-P synthase activity" RELATED [EC:2.5.1.55]
synonym: "KDO-8-phosphate synthetase activity" RELATED [EC:2.5.1.55]
synonym: "KDOP synthase activity" RELATED [EC:2.5.1.55]
synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" RELATED [EC:2.5.1.55]
synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" RELATED [EC:2.5.1.55]
xref: EC:2.5.1.55
xref: KEGG_REACTION:R03254
xref: MetaCyc:KDO-8PSYNTH-RXN
xref: RHEA:14053
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008677
name: 2-dehydropantoate 2-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH." [EC:1.1.1.169, RHEA:16233]
synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.169]
synonym: "2-ketopantoate reductase activity" RELATED [EC:1.1.1.169]
synonym: "2-ketopantoic acid reductase activity" RELATED [EC:1.1.1.169]
synonym: "2-oxopantoate reductase activity" RELATED [EC:1.1.1.169]
synonym: "ketopantoate reductase activity" RELATED [EC:1.1.1.169]
synonym: "ketopantoic acid reductase activity" RELATED [EC:1.1.1.169]
synonym: "KPA reductase activity" RELATED [EC:1.1.1.169]
xref: EC:1.1.1.169
xref: KEGG_REACTION:R02472
xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN
xref: RHEA:16233
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008678
name: 2-deoxy-D-gluconate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125]
synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.125]
synonym: "2-deoxygluconate dehydrogenase activity" RELATED [EC:1.1.1.125]
synonym: "2-keto-3-deoxygluconate oxidoreductase activity" RELATED [EC:1.1.1.125]
xref: EC:1.1.1.125
xref: MetaCyc:KDUD-RXN
xref: RHEA:12160
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008679
name: 2-hydroxy-3-oxopropionate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60]
synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.60]
synonym: "tartronate semialdehyde reductase (NADPH) activity" RELATED [EC:1.1.1.60]
xref: EC:1.1.1.60
xref: MetaCyc:TSA-REDUCT-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008681
name: 2-octaprenyl-6-methoxyphenol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+." [PMID:27822549, PMID:4572721, RHEA:29407]
xref: MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN
xref: RHEA:29407
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008682
name: 3-demethoxyubiquinol 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O." [RHEA:50908]
synonym: "2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity" NARROW []
synonym: "demethoxy-ubiquinone hydroxylase" RELATED [GOC:vw]
synonym: "demethoxyubiquinone monooxygenase" RELATED [GOC:vw]
xref: EC:1.14.99.60
xref: MetaCyc:RXN-18458
xref: RHEA:50908
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008683
name: 2-oxoglutarate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + H+ = CO2 + succinate semialdehyde." [EC:4.1.1.71, RHEA:10524]
synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" RELATED [EC:4.1.1.71]
synonym: "2-oxoglutarate carboxy-lyase activity" RELATED [EC:4.1.1.71]
synonym: "alpha-ketoglutarate decarboxylase activity" RELATED [EC:4.1.1.71]
synonym: "alpha-ketoglutaric decarboxylase activity" RELATED [EC:4.1.1.71]
synonym: "pre-2-oxoglutarate decarboxylase activity" RELATED [EC:4.1.1.71]
xref: EC:4.1.1.71
xref: KEGG_REACTION:R00272
xref: MetaCyc:RXN-7774
xref: RHEA:10524
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008684
name: 2-oxopent-4-enoate hydratase activity
namespace: molecular_function
alt_id: GO:0018821
def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80]
synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" RELATED [EC:4.2.1.80]
synonym: "2-keto-4-pentenoate hydratase activity" RELATED [EC:4.2.1.80]
synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" RELATED [EC:4.2.1.80]
synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" RELATED [EC:4.2.1.80]
synonym: "OEH activity" RELATED [EC:4.2.1.80]
xref: EC:4.2.1.80
xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN
xref: RHEA:22580
xref: UM-BBD_enzymeID:r0101
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008685
name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP." [EC:4.6.1.12, RHEA:23864]
synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" RELATED [EC:4.6.1.12]
synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" RELATED [EC:4.6.1.12]
synonym: "MECDP-synthase activity" RELATED [EC:4.6.1.12]
synonym: "MECP synthase activity" EXACT []
xref: EC:4.6.1.12
xref: KEGG_REACTION:R05637
xref: MetaCyc:RXN0-302
xref: RHEA:23864
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0008686
name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+." [EC:4.1.99.12, RHEA:18457]
xref: EC:4.1.99.12
xref: KEGG_REACTION:R07281
xref: MetaCyc:DIOHBUTANONEPSYN-RXN
xref: RHEA:18457
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0008687
name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+." [RHEA:15633]
synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.15]
synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" RELATED [EC:1.13.11.15]
synonym: "homoprotocatechuate 2,3-dioxygenase activity" RELATED [EC:1.13.11.15]
synonym: "HPC dioxygenase activity" RELATED [EC:1.13.11.15]
xref: EC:1.13.11.15
xref: KEGG_REACTION:R03303
xref: MetaCyc:1.13.11.15-RXN
xref: RHEA:15633
xref: UM-BBD_reactionID:r0364
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0008688
name: 3-(3-hydroxyphenyl)propionate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O." [RHEA:24785]
xref: EC:1.14.13.127
xref: KEGG_REACTION:R06786
xref: MetaCyc:MHPHYDROXY-RXN
xref: RHEA:24785
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008689
name: obsolete 3-demethylubiquinone-9 3-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph]
comment: This term was obsoleted because it represents a specific substrate of 3-demethylubiquinol-n 3-O-methyltransferase activity ; GO:0061542.
is_obsolete: true
replaced_by: GO:0061542

[Term]
id: GO:0008690
name: 3-deoxy-manno-octulosonate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38]
synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" RELATED [EC:2.7.7.38]
synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" RELATED [EC:2.7.7.38]
synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" RELATED [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" RELATED [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" RELATED [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" RELATED [EC:2.7.7.38]
synonym: "CMP-KDO synthetase activity" RELATED [EC:2.7.7.38]
synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" RELATED [EC:2.7.7.38]
synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT []
synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" RELATED [EC:2.7.7.38]
synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" RELATED [EC:2.7.7.38]
xref: EC:2.7.7.38
xref: MetaCyc:CPM-KDOSYNTH-RXN
xref: RHEA:23448
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0008691
name: 3-hydroxybutyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157]
synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.157]
synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.157]
synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.157]
synonym: "BHBD activity" RELATED [EC:1.1.1.157]
synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.157]
synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.157]
synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.157]
xref: EC:1.1.1.157
xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN
xref: RHEA:16197
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008692
name: 3-hydroxybutyryl-CoA epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3]
synonym: "3-hydroxyacyl-CoA epimerase activity" RELATED [EC:5.1.2.3]
synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" RELATED [EC:5.1.2.3]
synonym: "3-hydroxybutyryl coenzyme A epimerase activity" RELATED [EC:5.1.2.3]
xref: EC:5.1.2.3
xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN
xref: RHEA:21760
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0008693
name: obsolete (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [PMID:8910376]
comment: This term was obsoleted because it represents a specific substrate of (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity ; GO:0019171.
synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT []
synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT []
synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT []
synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT []
synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT []
synonym: "beta-hydroxydecanoate dehydrase activity" EXACT []
synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT []
is_obsolete: true
replaced_by: GO:0019171

[Term]
id: GO:0008694
name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
namespace: molecular_function
alt_id: GO:0019167
def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN]
synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT []
synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "PPHB decarboxylase activity" EXACT []
synonym: "UbiD" RELATED []
synonym: "UbiX" RELATED []
xref: EC:4.1.1.98
xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN
xref: RHEA:27778
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008695
name: 3-phenylpropionate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307]
synonym: "3-phenylpropanoate dioxygenase activity" RELATED [EC:1.14.12.19]
synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" RELATED [EC:1.14.12.19]
synonym: "Hca dioxygenase activity" RELATED [EC:1.14.12.19]
synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19]
xref: EC:1.14.12.19
xref: MetaCyc:HCAMULTI-RXN
xref: RHEA:20357
xref: UM-BBD_enzymeID:e0307
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0008696
name: 4-amino-4-deoxychorismate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate." [EC:4.1.3.38, RHEA:16201]
comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" RELATED [EC:4.1.3.38]
synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" RELATED [EC:4.1.3.38]
synonym: "ADC lyase activity" RELATED [EC:4.1.3.38]
synonym: "aminodeoxychorismate lyase activity" EXACT []
synonym: "enzyme X activity" RELATED [EC:4.1.3.38]
synonym: "p-aminobenzoate synthetase" RELATED []
synonym: "para-aminobenzoic acid (PABA) synthase" RELATED []
synonym: "para-aminobenzoic acid synthase" RELATED []
xref: EC:4.1.3.38
xref: KEGG_REACTION:R05553
xref: MetaCyc:ADCLY-RXN
xref: RHEA:16201
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008697
name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17, RHEA:23896]
synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.17]
synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" RELATED [EC:5.3.1.17]
synonym: "5-keto-4-deoxyuronate isomerase activity" RELATED [EC:5.3.1.17]
xref: EC:5.3.1.17
xref: KEGG_REACTION:R04383
xref: MetaCyc:5.3.1.17-RXN
xref: RHEA:23896
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008700
name: (R,S)-4-hydroxy-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Can act on both the (4R) and the (4S) enantiomers of 4-hydroxy-2-oxoglutarate." [EC:4.1.3.16, RHEA:18169]
synonym: "2-keto-4-hydroxybutyrate aldolase activity" RELATED [EC:4.1.3.16]
synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-keto-4-hydroxyglutaric aldolase activity" RELATED [EC:4.1.3.16]
synonym: "2-oxo-4-hydroxyglutarate aldolase activity" RELATED [EC:4.1.3.16]
synonym: "2-oxo-4-hydroxyglutaric aldolase activity" RELATED [EC:4.1.3.16]
synonym: "4-hydroxy-2-ketoglutarate aldolase activity" RELATED [EC:4.1.3.16]
synonym: "4-hydroxy-2-ketoglutaric aldolase activity" RELATED [EC:4.1.3.16]
synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" RELATED [EC:4.1.3.16]
synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" RELATED [EC:4.1.3.16]
synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" RELATED [EC:4.1.3.16]
synonym: "hydroxyketoglutarate aldolase activity" RELATED [EC:4.1.3.16]
synonym: "hydroxyketoglutaric aldolase activity" RELATED [EC:4.1.3.16]
synonym: "KHG-aldolase activity" RELATED [EC:4.1.3.16]
xref: EC:4.1.3.16
xref: Reactome:R-HSA-6784423 "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate"
xref: RHEA:18169
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008701
name: 4-hydroxy-2-oxovalerate aldolase activity
namespace: molecular_function
alt_id: GO:0018804
def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate." [EC:4.1.3.39, RHEA:22624]
synonym: "4-hydroxy-2-ketovalerate aldolase activity" RELATED [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" RELATED [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" RELATED [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" RELATED [EC:4.1.3.39]
synonym: "DmpG" RELATED [EC:4.1.3.39]
synonym: "HOA" RELATED [EC:4.1.3.39]
xref: EC:4.1.3.39
xref: KEGG_REACTION:R00750
xref: MetaCyc:MHPELY-RXN
xref: RHEA:22624
xref: UM-BBD_enzymeID:r0100
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008703
name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH." [EC:1.1.1.193, RHEA:17845]
synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT []
synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" RELATED [EC:1.1.1.193]
synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" RELATED [EC:1.1.1.193]
xref: EC:1.1.1.193
xref: KEGG_REACTION:R03458
xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN
xref: RHEA:17845
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008704
name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
namespace: molecular_function
alt_id: GO:0018843
def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10]
synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED []
synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT []
synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" RELATED [EC:5.3.3.10]
synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" RELATED [EC:5.3.3.10]
synonym: "CHM isomerase activity" RELATED [EC:5.3.3.10]
synonym: "HHDD isomerase activity" EXACT []
synonym: "hpaG-1" RELATED []
synonym: "hpaG1" RELATED []
xref: EC:5.3.3.10
xref: MetaCyc:5.3.3.10-RXN
xref: RHEA:18813
xref: UM-BBD_reactionID:r0366
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0008705
name: methionine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11172]
synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" RELATED [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT []
synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "cobalamin-dependent methionine synthase activity" RELATED [EC:2.1.1.13]
synonym: "MetH" RELATED [EC:2.1.1.13]
synonym: "methionine synthase (cobalamin-dependent) activity" RELATED [EC:2.1.1.13]
synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" RELATED [EC:2.1.1.13]
synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" RELATED [EC:2.1.1.13]
synonym: "tetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamate methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamic methyltransferase activity" RELATED [EC:2.1.1.13]
synonym: "vitamin B12 methyltransferase activity" RELATED [EC:2.1.1.13]
xref: EC:2.1.1.13
xref: KEGG_REACTION:R00946
xref: MetaCyc:HOMOCYSMETB12-RXN
xref: Reactome:R-HSA-174374 "MTR transfers CH3 from MeCbl to HCYS"
xref: Reactome:R-HSA-3149539 "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin"
xref: RHEA:11172
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0008706
name: 6-phospho-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86]
synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" RELATED [EC:3.2.1.86]
synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86]
synonym: "phospho-beta-glucosidase activity" RELATED [EC:3.2.1.86]
synonym: "phosphocellobiase activity" RELATED [EC:3.2.1.86]
xref: EC:3.2.1.86
xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN
xref: RHEA:10772
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0008707
name: 4-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26]
synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26]
synonym: "6-phytase activity" EXACT []
synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.26]
synonym: "phytase activity" BROAD [EC:3.1.3.26]
synonym: "phytate 6-phosphatase activity" RELATED [EC:3.1.3.26]
xref: EC:3.1.3.26
xref: MetaCyc:RXN-7241
xref: RHEA:20960
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008709
name: cholate 7-alpha-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholate + NAD+ = -3alpha,12-alpha-dihydroxy-7-oxo--5beta-cholanate + H+ + NADH." [RHEA:19409]
synonym: "7-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159]
synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159]
synonym: "7alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.159]
synonym: "7alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159]
synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" BROAD [EC:1.1.1.159]
xref: EC:1.1.1.159
xref: KEGG_REACTION:R02792
xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN
xref: RHEA:19409
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008710
name: 8-amino-7-oxononanoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA." [EC:2.3.1.47, RHEA:20712]
synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" RELATED [EC:2.3.1.47]
synonym: "7-KAP synthetase activity" RELATED [EC:2.3.1.47]
synonym: "7-keto-8-amino-pelargonic acid synthetase activity" RELATED [EC:2.3.1.47]
synonym: "7-keto-8-aminopelargonic acid synthetase activity" RELATED [EC:2.3.1.47]
synonym: "7-keto-8-aminopelargonic synthetase activity" RELATED [EC:2.3.1.47]
synonym: "8-amino-7-ketopelargonate synthase activity" RELATED [EC:2.3.1.47]
synonym: "8-amino-7-oxopelargonate synthase activity" RELATED [EC:2.3.1.47]
synonym: "AONS activity" RELATED [EC:2.3.1.47]
xref: EC:2.3.1.47
xref: KEGG_REACTION:R03210
xref: MetaCyc:7KAPSYN-RXN
xref: RHEA:20712
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0008711
name: obsolete ADP-L-glycero-D-manno-heptose synthase activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:curators]
comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE).
synonym: "ADP-L-glycero-D-manno-heptose synthase activity" EXACT []
is_obsolete: true
consider: GO:0033785
consider: GO:0033786

[Term]
id: GO:0008712
name: ADP-glyceromanno-heptose 6-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20, RHEA:17577]
synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" RELATED [EC:5.1.3.20]
synonym: "ADPglyceromanno-heptose 6-epimerase activity" RELATED [EC:5.1.3.20]
xref: EC:5.1.3.20
xref: KEGG_REACTION:R05176
xref: MetaCyc:5.1.3.20-RXN
xref: RHEA:17577
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008713
name: ADP-heptose-lipopolysaccharide heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [RHEA:74071]
synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY]
xref: EC:2.4.99.24
xref: MetaCyc:RXN-22477
xref: RHEA:74071
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity

[Term]
id: GO:0008714
name: AMP nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine." [EC:3.2.2.4, RHEA:20129]
synonym: "adenosine monophosphate nucleosidase activity" RELATED [EC:3.2.2.4]
synonym: "adenylate nucleosidase activity" RELATED [EC:3.2.2.4]
synonym: "AMP phosphoribohydrolase activity" RELATED [EC:3.2.2.4]
xref: EC:3.2.2.4
xref: KEGG_REACTION:R00182
xref: MetaCyc:AMP-NUCLEOSID-RXN
xref: RHEA:20129
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008715
name: CDP-diacylglycerol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+." [EC:3.6.1.26, RHEA:15221]
synonym: "CDP diacylglycerol hydrolase activity" RELATED [EC:3.6.1.26]
synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" RELATED [EC:3.6.1.26]
synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT []
synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" RELATED [EC:3.6.1.26]
xref: EC:3.6.1.26
xref: KEGG_REACTION:R01797
xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN
xref: RHEA:15221
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008716
name: D-alanine-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate." [EC:6.3.2.4, RHEA:11224]
synonym: "alanine:alanine ligase (ADP-forming) activity" RELATED [EC:6.3.2.4]
synonym: "alanylalanine synthetase activity" RELATED [EC:6.3.2.4]
synonym: "D-Ala-D-Ala synthetase activity" RELATED [EC:6.3.2.4]
synonym: "D-alanine:D-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.4]
synonym: "D-alanyl-D-alanine synthetase activity" RELATED [EC:6.3.2.4]
synonym: "D-alanylalanine synthetase activity" RELATED [EC:6.3.2.4]
xref: EC:6.3.2.4
xref: KEGG_REACTION:R01150
xref: MetaCyc:DALADALALIG-RXN
xref: RHEA:11224
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008717
name: obsolete D-alanyl-D-alanine endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "D-alanyl-D-alanine endopeptidase activity" EXACT []
synonym: "penicillin-binding protein 7" NARROW []
synonym: "penicillin-binding protein 8" NARROW []
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0008718
name: D-amino-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [RHEA:18125]
synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT []
synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT []
xref: RHEA:18125
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0008719
name: dihydroneopterin triphosphate 2'-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN]
synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT []
xref: EC:5.1.99.7
xref: MetaCyc:H2NTPEPIM-RXN
xref: RHEA:28346
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0008720
name: D-lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate." [EC:1.1.1.28, RHEA:16369]
synonym: "D-lactic acid dehydrogenase activity" RELATED [EC:1.1.1.28]
synonym: "D-lactic dehydrogenase activity" RELATED [EC:1.1.1.28]
xref: EC:1.1.1.28
xref: KEGG_REACTION:R00704
xref: MetaCyc:DLACTDEHYDROGNAD-RXN
xref: RHEA:16369
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008721
name: D-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18]
synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18]
synonym: "D-hydroxyaminoacid dehydratase activity" RELATED [EC:4.3.1.18]
synonym: "D-serine ammonia-lyase (pyruvate-forming)" RELATED [EC:4.3.1.18]
synonym: "D-serine deaminase activity" RELATED [EC:4.3.1.18]
synonym: "D-serine dehydrase activity" RELATED [EC:4.3.1.18]
synonym: "D-serine dehydratase (deaminating) activity" RELATED [EC:4.3.1.18]
synonym: "D-serine dehydratase activity" RELATED [EC:4.3.1.18]
synonym: "D-serine dehydration activity" RELATED []
synonym: "D-serine hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.18]
synonym: "D-serine hydrolase activity" RELATED [EC:4.3.1.18]
xref: EC:4.3.1.18
xref: MetaCyc:DSERDEAM-RXN
xref: Reactome:R-HSA-9014741 "PXLP-K56-SRR dimer deaminates D-Ser"
xref: Reactome:R-HSA-9034539 "PXLP-K56-SRR dimer deaminates L-Ser"
xref: RHEA:13977
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008724
name: obsolete DNA topoisomerase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059]
comment: This term was made obsolete because it represents a gene product.
synonym: "DNA topoisomerase IV activity" EXACT []
is_obsolete: true
replaced_by: GO:0003918

[Term]
id: GO:0008725
name: DNA-3-methyladenine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623]
synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20]
synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20]
synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20]
synonym: "DNA-3-methyladenine glycosidase I activity" RELATED [EC:3.2.2.20]
synonym: "DNA-3-methyladenine glycosylase I activity" EXACT []
xref: EC:3.2.2.20
xref: MetaCyc:RXN0-5189
is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity

[Term]
id: GO:0008726
name: alkanesulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN." [MetaCyc:RXN0-280]
synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" RELATED [EC:1.14.14.5]
synonym: "alkanesulphonate monooxygenase activity" EXACT []
synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" RELATED [EC:1.14.14.5]
synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT []
synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" RELATED [EC:1.14.14.5]
synonym: "SsuD" RELATED [EC:1.14.14.5]
synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5]
xref: EC:1.14.14.5
xref: MetaCyc:RXN0-280
xref: RHEA:23064
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008727
name: GDP-mannose mannosyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN]
xref: MetaCyc:GDPMANMANHYDRO-RXN
xref: RHEA:28102
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0008728
name: GTP diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5]
synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5]
synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5]
synonym: "ATP-GTP 3'-diphosphotransferase activity" RELATED [EC:2.7.6.5]
synonym: "ATP:GTP 3'-diphosphotransferase activity" RELATED [EC:2.7.6.5]
synonym: "GPSI" RELATED [EC:2.7.6.5]
synonym: "GPSII" RELATED [EC:2.7.6.5]
synonym: "GTP pyrophosphokinase activity" EXACT []
synonym: "guanosine 3',5'-polyphosphate synthase activity" RELATED [EC:2.7.6.5]
synonym: "guanosine 5',3'-polyphosphate synthetase activity" RELATED [EC:2.7.6.5]
synonym: "guanosine pentaphosphate synthetase activity" RELATED [EC:2.7.6.5]
synonym: "ppGpp synthetase I activity" RELATED [EC:2.7.6.5]
synonym: "stringent factor activity" RELATED [EC:2.7.6.5]
xref: EC:2.7.6.5
xref: MetaCyc:GTPPYPHOSKIN-RXN
xref: RHEA:22088
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0008730
name: L(+)-tartrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tartrate = H2O + oxaloacetate." [EC:4.2.1.32, RHEA:15413]
synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" RELATED [EC:4.2.1.32]
synonym: "(R,R)-tartrate hydro-lyase activity" RELATED [EC:4.2.1.32]
synonym: "L-(+)-tartaric acid dehydratase activity" RELATED [EC:4.2.1.32]
synonym: "L-tartrate dehydratase activity" RELATED [EC:4.2.1.32]
synonym: "tartaric acid dehydrase activity" RELATED [EC:4.2.1.32]
synonym: "tartrate dehydratase activity" RELATED [EC:4.2.1.32]
xref: EC:4.2.1.32
xref: KEGG_REACTION:R00339
xref: MetaCyc:LTARTDEHYDRA-RXN
xref: RHEA:15413
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008732
name: L-allo-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [PMID:9228760, RHEA:26209]
synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT []
synonym: "LtaA" RELATED []
xref: EC:4.1.2.49
xref: MetaCyc:LTAA-RXN
xref: RHEA:26209
is_a: GO:0004793 ! threonine aldolase activity

[Term]
id: GO:0008733
name: L-arabinose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4, RHEA:14821]
synonym: "L-arabinose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.4]
synonym: "L-arabinose ketol-isomerase activity" RELATED [EC:5.3.1.4]
xref: EC:5.3.1.4
xref: KEGG_REACTION:R01761
xref: MetaCyc:ARABISOM-RXN
xref: RHEA:14821
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008734
name: L-aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2. Can also use fumatate as electron acceptor under anaerobic conditions, yielding succinate." [EC:1.4.3.16]
synonym: "L-aspartate:oxygen oxidoreductase" RELATED [EC:1.4.3.16]
xref: EC:1.4.3.16
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0008735
name: L-carnitine CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA." [PMID:7815937, PMID:8188598]
synonym: "L-carnitine dehydratase activity" EXACT []
synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED []
synonym: "L-carnitine hydro-lyase activity" RELATED []
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008736
name: L-fucose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fucose = L-fuculose." [RHEA:17233]
synonym: "L-fucose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.25]
synonym: "L-fucose ketol-isomerase activity" RELATED [EC:5.3.1.25]
xref: EC:5.3.1.25
xref: MetaCyc:FUCISOM-RXN
xref: RHEA:17233
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008737
name: L-fuculokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+." [EC:2.7.1.51, RHEA:12376]
synonym: "ATP:L-fuculose 1-phosphotransferase activity" RELATED [EC:2.7.1.51]
synonym: "L-fuculokinase (phosphorylating)" RELATED [EC:2.7.1.51]
synonym: "L-fuculose kinase activity" RELATED [EC:2.7.1.51]
xref: EC:2.7.1.51
xref: KEGG_REACTION:R03241
xref: MetaCyc:FUCULOKIN-RXN
xref: RHEA:12376
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008738
name: L-fuculose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate." [EC:4.1.2.17, RHEA:12933]
synonym: "fuculose aldolase activity" RELATED [EC:4.1.2.17]
synonym: "L-fuculose 1-phosphate aldolase activity" RELATED [EC:4.1.2.17]
synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" RELATED [EC:4.1.2.17]
synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.17]
xref: EC:4.1.2.17
xref: KEGG_REACTION:R02262
xref: MetaCyc:FUCPALDOL-RXN
xref: RHEA:12933
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008740
name: L-rhamnose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [RHEA:23160]
synonym: "L-rhamnose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.14]
synonym: "L-rhamnose ketol-isomerase activity" RELATED [EC:5.3.1.14]
synonym: "rhamnose isomerase activity" RELATED [EC:5.3.1.14]
xref: EC:5.3.1.14
xref: KEGG_REACTION:R02437
xref: MetaCyc:RHAMNISOM-RXN
xref: RHEA:23160
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008741
name: ribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16]
synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" RELATED [EC:2.7.1.16]
synonym: "L-ribulokinase activity" EXACT []
synonym: "ribulokinase (phosphorylating)" RELATED [EC:2.7.1.16]
xref: EC:2.7.1.16
xref: MetaCyc:RIBULOKIN-RXN
xref: RHEA:22072
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008742
name: L-ribulose-phosphate 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.4, RHEA:22368]
synonym: "AraD" RELATED [EC:5.1.3.4]
synonym: "L-ribulose 5-phosphate 4-epimerase activity" RELATED [EC:5.1.3.4]
synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4]
synonym: "L-Ru5P" RELATED [EC:5.1.3.4]
synonym: "L-ru5P activity" RELATED [EC:5.1.3.4]
synonym: "phosphoribulose isomerase activity" RELATED [EC:5.1.3.4]
synonym: "ribulose phosphate 4-epimerase activity" RELATED [EC:5.1.3.4]
xref: EC:5.1.3.4
xref: KEGG_REACTION:R05850
xref: MetaCyc:RIBULPEPIM-RXN
xref: RHEA:22368
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008743
name: L-threonine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + CO2 + NADH." [EC:1.1.1.103, RHEA:13161]
synonym: "L-threonine dehydrogenase activity" RELATED [EC:1.1.1.103]
synonym: "L-threonine:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.103]
synonym: "threonine 3-dehydrogenase activity" BROAD []
synonym: "threonine dehydrogenase activity" RELATED [EC:1.1.1.103]
xref: EC:1.1.1.103
xref: KEGG_REACTION:R01465
xref: MetaCyc:THREODEHYD-RXN
xref: Reactome:R-HSA-6798667 "TDH tetramer oxidises L-Thr to 2A-3OB"
xref: RHEA:13161
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008744
name: L-xylulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53]
synonym: "ATP:L-xylulose 5-phosphotransferase activity" RELATED [EC:2.7.1.53]
synonym: "L-xylulokinase (phosphorylating)" RELATED [EC:2.7.1.53]
synonym: "L-xylulose kinase activity" RELATED [EC:2.7.1.53]
xref: EC:2.7.1.53
xref: MetaCyc:LYXK-RXN
xref: RHEA:18869
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008745
name: N-acetylmuramoyl-L-alanine amidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28, PMID:22748813]
synonym: "acetylmuramoyl-alanine amidase activity" RELATED [EC:3.5.1.28]
synonym: "acetylmuramyl-alanine amidase activity" RELATED [EC:3.5.1.28]
synonym: "acetylmuramyl-L-alanine amidase activity" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramic acid L-alanine amidase activity" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramyl-L-alanine amidase activity" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramylalanine amidase activity" RELATED [EC:3.5.1.28]
synonym: "N-acylmuramyl-L-alanine amidase activity" RELATED [EC:3.5.1.28]
xref: EC:3.5.1.28
xref: MetaCyc:3.4.24.32-RXN
xref: Reactome:R-HSA-6799977 "PGLYRP2 hydrolyzes bacterial peptidoglycan"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0061783 ! peptidoglycan muralytic activity

[Term]
id: GO:0008746
name: obsolete NAD(P)+ transhydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.2]
comment: The reason for obsoletion is that the term is an unnecessary grouping class.
is_obsolete: true
consider: GO:0003957
consider: GO:0008750

[Term]
id: GO:0008747
name: N-acetylneuraminate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3, RHEA:23296]
synonym: "acetylneuraminate lyase activity" RELATED [EC:4.1.3.3]
synonym: "acetylneuraminate pyruvate-lyase activity" RELATED [EC:4.1.3.3]
synonym: "N-acetylneuraminate aldolase activity" RELATED [EC:4.1.3.3]
synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" RELATED [EC:4.1.3.3]
synonym: "N-acetylneuraminate pyruvate-lyase activity" RELATED [EC:4.1.3.3]
synonym: "N-acetylneuraminic acid aldolase activity" RELATED [EC:4.1.3.3]
synonym: "N-acetylneuraminic acid lyase activity" RELATED [EC:4.1.3.3]
synonym: "N-acetylneuraminic aldolase activity" RELATED [EC:4.1.3.3]
synonym: "N-acetylneuraminic lyase activity" RELATED [EC:4.1.3.3]
synonym: "NALase activity" RELATED [EC:4.1.3.3]
synonym: "NANA lyase activity" RELATED [EC:4.1.3.3]
synonym: "neuraminate aldolase activity" RELATED [EC:4.1.3.3]
synonym: "neuraminic acid aldolase activity" RELATED [EC:4.1.3.3]
synonym: "neuraminic aldolase activity" RELATED [EC:4.1.3.3]
synonym: "NPL" RELATED [EC:4.1.3.3]
synonym: "sialate lyase activity" RELATED [EC:4.1.3.3]
synonym: "sialic acid aldolase activity" RELATED [EC:4.1.3.3]
synonym: "sialic aldolase activity" RELATED [EC:4.1.3.3]
xref: EC:4.1.3.3
xref: KEGG_REACTION:R01811
xref: MetaCyc:RXN0-7390
xref: Reactome:R-HSA-4085217 "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate"
xref: RHEA:23296
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008748
name: N-ethylmaleimide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+." [MetaCyc:RXN0-5101]
xref: MetaCyc:RXN0-5101
xref: RHEA:35523
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008750
name: proton-translocating NAD(P)+ transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+." [RHEA:47992]
synonym: "NAD(P)+ transhydrogenase (AB-specific) activity" RELATED []
xref: EC:7.1.1.1
xref: RHEA:47992
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0008751
name: obsolete NAD(P)H dehydrogenase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a redundant grouping term with only one child.
synonym: "NAD(P)H dehydrogenase" EXACT []
is_obsolete: true
consider: GO:0016651

[Term]
id: GO:0008752
name: FMN reductase (NAD(P)H) activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates." [EC:1.5.1.39]
synonym: "flavin mononucleotide reductase activity" RELATED []
synonym: "FMN reductase activity" BROAD []
synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT []
synonym: "NAD(P)H-dependent FMN reductase activity" RELATED []
xref: EC:1.5.1.39
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008753
name: NADPH dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol." [RHEA:46164]
synonym: "NADPH oxidase" BROAD [EC:1.6.5.10]
synonym: "NADPH:(quinone-acceptor) oxidoreductase" RELATED [EC:1.6.5.10]
synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" RELATED [EC:1.6.5.10]
xref: EC:1.6.5.10
xref: KEGG_REACTION:R07359
xref: MetaCyc:RXN0-7385
xref: RHEA:46164
is_a: GO:0003955 ! NAD(P)H dehydrogenase (quinone) activity

[Term]
id: GO:0008754
name: O antigen ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: Lipid A-core + colanic acid = MLPS." [MetaCyc:RXN0-5294]
xref: MetaCyc:RXN0-5294
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0008755
name: O antigen polymerase activity
namespace: molecular_function
def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, PMID:12045108]
synonym: "O-antigen polymerase activity" EXACT []
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0008756
name: o-succinylbenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26]
synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.26]
synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.26]
synonym: "o-succinylbenzoyl-CoA synthetase activity" RELATED [EC:6.2.1.26]
synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" RELATED [EC:6.2.1.26]
synonym: "OSB-CoA synthetase activity" RELATED [EC:6.2.1.26]
xref: EC:6.2.1.26
xref: KEGG_REACTION:R04030
xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN
xref: RHEA:17009
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008757
name: S-adenosylmethionine-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]
synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT []
synonym: "SAM-dependent methyltransferase activity" EXACT []
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008758
name: UDP-2,3-diacylglucosamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770]
xref: MetaCyc:LIPIDXSYNTHESIS-RXN
xref: RHEA:25213
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008759
name: obsolete UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271]
comment: This term was obsoleted because it represents a specific substrate of UDP-3-O-acyl-N-acetylglucosamine deacetylase activity ; GO:0103117.
is_obsolete: true
replaced_by: GO:0103117

[Term]
id: GO:0008760
name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7, RHEA:18681]
synonym: "enoylpyruvate transferase activity" RELATED [EC:2.5.1.7]
synonym: "MurA transferase activity" NARROW [EC:2.5.1.7]
synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" RELATED [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" RELATED [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" RELATED [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" RELATED [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" RELATED [EC:2.5.1.7]
synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" RELATED [EC:2.5.1.7]
synonym: "pyruvate-UDP-acetylglucosamine transferase activity" RELATED [EC:2.5.1.7]
synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" RELATED [EC:2.5.1.7]
synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" RELATED [EC:2.5.1.7]
synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" RELATED [EC:2.5.1.7]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" RELATED [EC:2.5.1.7]
synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" RELATED [EC:2.5.1.7]
xref: EC:2.5.1.7
xref: KEGG_REACTION:R00660
xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN
xref: RHEA:18681
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008761
name: UDP-N-acetylglucosamine 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14]
synonym: "UDP-GlcNAc-2-epimerase activity" RELATED [EC:5.1.3.14]
synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" RELATED [EC:5.1.3.14]
synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" RELATED [EC:5.1.3.14]
synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" RELATED [EC:5.1.3.14]
synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" RELATED [EC:5.1.3.14]
synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" RELATED [EC:5.1.3.14]
xref: EC:5.1.3.14
xref: MetaCyc:UDPGLCNACEPIM-RXN
xref: Reactome:R-HSA-4085021 "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP"
xref: Reactome:R-HSA-4088338 "Defective GNE does not hydrolyse UDP-GlcNAc"
xref: RHEA:17213
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008762
name: UDP-N-acetylmuramate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.3.1.98]
synonym: "MurB reductase" RELATED [EC:1.3.1.98]
synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" RELATED [EC:1.3.1.98]
synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" RELATED [EC:1.3.1.98]
synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" RELATED [EC:1.3.1.98]
synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.98]
synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" RELATED [EC:1.3.1.98]
synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" RELATED [EC:1.3.1.98]
synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" RELATED [EC:1.3.1.98]
xref: EC:1.3.1.98
xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN
xref: RHEA:12248
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008763
name: UDP-N-acetylmuramate-L-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8, RHEA:23372]
synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8]
synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8]
synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8]
synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8]
synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" RELATED [EC:6.3.2.8]
synonym: "UDP-MurNAc:L-alanine ligase activity" RELATED [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" RELATED [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramoylalanine synthetase activity" RELATED [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" RELATED [EC:6.3.2.8]
synonym: "UDPMurNAc-L-alanine synthetase activity" RELATED [EC:6.3.2.8]
synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" RELATED [EC:6.3.2.8]
synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" RELATED [EC:6.3.2.8]
synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" RELATED [EC:6.3.2.8]
synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" RELATED [EC:6.3.2.8]
xref: EC:6.3.2.8
xref: KEGG_REACTION:R03193
xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN
xref: RHEA:23372
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008764
name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [RHEA:16429]
synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9]
synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9]
synonym: "MurD synthetase activity" RELATED [EC:6.3.2.9]
synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" RELATED [EC:6.3.2.9]
synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" RELATED [EC:6.3.2.9]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" RELATED [EC:6.3.2.9]
synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" RELATED [EC:6.3.2.9]
xref: EC:6.3.2.9
xref: KEGG_REACTION:R02783
xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN
xref: RHEA:16429
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008765
name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13, RHEA:23676]
synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" RELATED [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" RELATED [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" RELATED [EC:6.3.2.13]
xref: EC:6.3.2.13
xref: KEGG_REACTION:R02788
xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN
xref: RHEA:23676
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008766
name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [RHEA:28374]
xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN
xref: RHEA:28374
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008767
name: UDP-galactopyranose mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9]
synonym: "UDP-D-galactopyranose furanomutase activity" RELATED [EC:5.4.99.9]
synonym: "UDPgalactopyranose mutase activity" RELATED [EC:5.4.99.9]
xref: EC:5.4.99.9
xref: MetaCyc:GALPMUT-RXN
xref: RHEA:24132
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0008768
name: UDP-sugar diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45]
synonym: "nucleosidediphosphate-sugar diphosphatase activity" BROAD [EC:3.6.1.45]
synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" BROAD [EC:3.6.1.45]
synonym: "UDP-sugar hydrolase activity" RELATED [EC:3.6.1.45]
synonym: "UDP-sugar pyrophosphatase activity" RELATED [EC:3.6.1.45]
synonym: "UDP-sugar sugarphosphohydrolase activity" RELATED [EC:3.6.1.45]
xref: EC:3.6.1.45
xref: MetaCyc:UDPSUGARHYDRO-RXN
xref: Reactome:R-HSA-6810464 "NUDT14 hydrolyses UDP-Glc to G1P and UMP"
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008769
name: obsolete X-His dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoacyl-histidine dipeptidase activity" RELATED [EC:3.4.13.3]
synonym: "aminoacylhistidine dipeptidase activity" RELATED [EC:3.4.13.3]
synonym: "carnosinase activity" RELATED [EC:3.4.13.3]
synonym: "dipeptidase M" RELATED [EC:3.4.13.3]
synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3]
synonym: "X-His dipeptidase activity" EXACT []
synonym: "Xaa-His dipeptidase activity" EXACT []
is_obsolete: true
consider: GO:0008235
consider: GO:0016805

[Term]
id: GO:0008770
name: [acyl-carrier-protein] phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14]
synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT []
synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" RELATED [EC:3.1.4.14]
synonym: "ACP hydrolyase activity" RELATED [EC:3.1.4.14]
synonym: "ACP phosphodiesterase activity" EXACT []
synonym: "AcpH" RELATED [EC:3.1.4.14]
synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" RELATED [EC:3.1.4.14]
synonym: "acyl-carrier-protein phosphodiesterase activity" RELATED [EC:3.1.4.14]
synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" RELATED [EC:3.1.4.14]
xref: EC:3.1.4.14
xref: MetaCyc:3.1.4.14-RXN
xref: RHEA:20537
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008771
name: [citrate (pro-3S)-lyase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22]
synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" RELATED [EC:6.2.1.22]
synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22]
synonym: "acetate:HS-citrate lyase ligase activity" RELATED [EC:6.2.1.22]
synonym: "citrate (pro-3S)-lyase ligase activity" RELATED [EC:6.2.1.22]
synonym: "citrate lyase ligase activity" RELATED [EC:6.2.1.22]
synonym: "citrate lyase synthetase activity" RELATED [EC:6.2.1.22]
xref: EC:6.2.1.22
xref: KEGG_REACTION:R04449
xref: MetaCyc:CITC-RXN
xref: RHEA:23788
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008772
name: [isocitrate dehydrogenase (NADP+)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H+ + O-phospho-L-seryl-[isocitrate dehydrogenase]." [RHEA:43540]
synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" RELATED [EC:2.7.11.5]
synonym: "ICDH kinase/phosphatase activity" BROAD [EC:2.7.11.5]
synonym: "IDH kinase activity" RELATED [EC:2.7.11.5]
synonym: "IDH kinase/phosphatase activity" BROAD [EC:2.7.11.5]
synonym: "IDH-K/P" RELATED [EC:2.7.11.5]
synonym: "IDHK/P" BROAD [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase (NADP) kinase activity" RELATED [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase (NADP+) kinase activity" RELATED [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase activity" RELATED [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5]
xref: EC:2.7.11.5
xref: MetaCyc:PHOSICITDEHASE-RXN
xref: RHEA:43540
is_a: GO:0106310 ! protein serine kinase activity

[Term]
id: GO:0008773
name: [protein-PII] uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59]
synonym: "PII uridylyl-transferase activity" RELATED [EC:2.7.7.59]
synonym: "protein-PII uridylyltransferase activity" RELATED [EC:2.7.7.59]
synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59]
synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59]
synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT []
synonym: "UTP:protein-PII uridylyltransferase activity" RELATED [EC:2.7.7.59]
xref: EC:2.7.7.59
xref: MetaCyc:URITRANS-RXN
xref: RHEA:13673
is_a: GO:0070569 ! uridylyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008774
name: acetaldehyde dehydrogenase (acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10]
synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.1.10]
synonym: "acylating acetaldehyde dehydrogenase activity" RELATED [EC:1.2.1.10]
synonym: "ADA" RELATED [EC:1.2.1.10]
synonym: "aldehyde dehydrogenase (acylating) activity" RELATED [EC:1.2.1.10]
synonym: "DmpF" RELATED [EC:1.2.1.10]
xref: EC:1.2.1.10
xref: MetaCyc:ACETALD-DEHYDROG-RXN
xref: RHEA:23288
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008775
name: acetate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8]
synonym: "acetate coenzyme A-transferase activity" RELATED [EC:2.8.3.8]
synonym: "acetyl-CoA:acetoacetate CoA transferase activity" RELATED [EC:2.8.3.8]
synonym: "acyl-CoA:acetate CoA-transferase activity" RELATED [EC:2.8.3.8]
synonym: "butyryl CoA:acetate CoA transferase activity" RELATED [EC:2.8.3.8]
synonym: "butyryl coenzyme A transferase activity" RELATED [EC:2.8.3.8]
synonym: "succinyl-CoA:acetate CoA transferase activity" RELATED [EC:2.8.3.8]
xref: EC:2.8.3.8
xref: MetaCyc:ACECOATRANS-RXN
xref: Reactome:R-HSA-2066788 "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase"
xref: RHEA:13381
xref: UM-BBD_enzymeID:r0012
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008776
name: acetate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1]
synonym: "acetate kinase (phosphorylating) activity" RELATED [EC:2.7.2.1]
synonym: "acetic kinase activity" RELATED [EC:2.7.2.1]
synonym: "acetokinase activity" RELATED [EC:2.7.2.1]
synonym: "AckA" RELATED [EC:2.7.2.1]
synonym: "AK activity" RELATED [EC:2.7.2.1]
synonym: "ATP:acetate phosphotransferase activity" RELATED [EC:2.7.2.1]
xref: EC:2.7.2.1
xref: MetaCyc:ACETATEKIN-RXN
xref: RHEA:11352
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008777
name: acetylornithine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16]
synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" RELATED [EC:3.5.1.16]
synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16]
synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16]
synonym: "N2-acetyl-L-ornithine amidohydrolase activity" RELATED [EC:3.5.1.16]
xref: EC:3.5.1.16
xref: MetaCyc:ACETYLORNDEACET-RXN
xref: RHEA:15941
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008779
name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40]
synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT []
synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT []
synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" RELATED [EC:2.3.1.40]
synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" RELATED [EC:2.3.1.40]
xref: EC:2.3.1.40
xref: MetaCyc:ACYLGPEACYLTRANS-RXN
xref: RHEA:10304
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0008780
name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129]
synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" RELATED [EC:2.3.1.129]
synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT []
synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT []
synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129]
synonym: "UDP-N-acetylglucosamine acyltransferase activity" RELATED [EC:2.3.1.129]
synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" RELATED [EC:2.3.1.129]
xref: EC:2.3.1.129
xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN
xref: RHEA:13925
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0008781
name: N-acylneuraminate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43]
synonym: "acetylneuraminate cytidylyltransferase activity" RELATED [EC:2.7.7.43]
synonym: "acylneuraminate cytidyltransferase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminate synthase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminate synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminic acid synthase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminic acid synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-NANA synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-Neu5Ac synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-NeuAc synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-NeuNAc synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-sialate diphosphorylase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-sialate pyrophosphorylase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-sialate synthase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-sialate synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-sialic acid synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CMP-sialic synthetase activity" RELATED [EC:2.7.7.43]
synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT []
synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" RELATED [EC:2.7.7.43]
synonym: "cytidine 5'-monophosphosialic acid synthetase activity" RELATED [EC:2.7.7.43]
synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" RELATED [EC:2.7.7.43]
synonym: "cytidine monophosphoacetylneuraminic synthetase activity" RELATED [EC:2.7.7.43]
synonym: "cytidine monophosphosialate pyrophosphorylase activity" RELATED [EC:2.7.7.43]
synonym: "cytidine monophosphosialate synthetase activity" RELATED [EC:2.7.7.43]
synonym: "cytidine monophosphosialic acid synthetase activity" RELATED [EC:2.7.7.43]
xref: EC:2.7.7.43
xref: MetaCyc:RXN-9990
xref: Reactome:R-HSA-4084982 "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac"
xref: RHEA:11344
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0008782
name: adenosylhomocysteine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9]
synonym: "5'-methyladenosine nucleosidase activity" RELATED [EC:3.2.2.9]
synonym: "AdoHcy/MTA nucleosidase activity" RELATED [EC:3.2.2.9]
synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" RELATED [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine nucleosidase activity" RELATED [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" RELATED [EC:3.2.2.9]
xref: EC:3.2.2.9
xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN
xref: RHEA:17805
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008783
name: agmatinase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + H2O = putrescine + urea." [EC:3.5.3.11, RHEA:13929]
synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11]
synonym: "agmatine ureohydrolase activity" RELATED [EC:3.5.3.11]
synonym: "SpeB" RELATED [EC:3.5.3.11]
xref: EC:3.5.3.11
xref: KEGG_REACTION:R01157
xref: MetaCyc:AGMATIN-RXN
xref: Reactome:R-HSA-350604 "Agmatine + H2O <=> putrescine + urea"
xref: RHEA:13929
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0008784
name: alanine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1, RHEA:20249]
synonym: "L-alanine racemase activity" RELATED [EC:5.1.1.1]
xref: EC:5.1.1.1
xref: KEGG_REACTION:R00401
xref: MetaCyc:ALARACECAT-RXN
xref: RHEA:20249
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008785
name: alkyl hydroperoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [GOC:curators]
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0008786
name: D-allose 6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [RHEA:28430]
synonym: "allose 6-phosphate isomerase activity" NARROW []
xref: MetaCyc:RXN0-303
xref: RHEA:28430
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008787
name: D-allose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55]
synonym: "allokinase (phosphorylating)" RELATED [EC:2.7.1.55]
synonym: "allokinase activity" RELATED [EC:2.7.1.55]
synonym: "allose kinase activity" NARROW []
synonym: "ATP:D-allose 6-phosphotransferase activity" RELATED [EC:2.7.1.55]
synonym: "D-allokinase activity" RELATED [EC:2.7.1.55]
synonym: "D-allose-6-kinase activity" RELATED [EC:2.7.1.55]
xref: EC:2.7.1.55
xref: MetaCyc:ALLOSE-KINASE-RXN
xref: RHEA:14805
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0008788
name: alpha,alpha-phosphotrehalase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93]
synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" RELATED [EC:3.2.1.93]
synonym: "phosphotrehalase activity" RELATED [EC:3.2.1.93]
synonym: "trehalose-6-phosphate hydrolase activity" RELATED [EC:3.2.1.93]
xref: EC:3.2.1.93
xref: MetaCyc:TRE6PHYDRO-RXN
xref: RHEA:23008
is_a: GO:0015927 ! trehalase activity

[Term]
id: GO:0008789
name: altronate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.7, RHEA:15957]
synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" RELATED [EC:4.2.1.7]
synonym: "D-altronate hydro-lyase activity" RELATED [EC:4.2.1.7]
xref: EC:4.2.1.7
xref: KEGG_REACTION:R01540
xref: MetaCyc:ALTRODEHYDRAT-RXN
xref: RHEA:15957
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008790
name: arabinose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3]
synonym: "D-arabinose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.3]
synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3]
synonym: "D-arabinose ketol-isomerase activity" RELATED [EC:5.3.1.3]
synonym: "D-arabinose(L-fucose) isomerase activity" RELATED [EC:5.3.1.3]
xref: EC:5.3.1.3
xref: MetaCyc:DARABISOM-RXN
xref: RHEA:13849
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008791
name: arginine N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109]
synonym: "AOST activity" RELATED [EC:2.3.1.109]
synonym: "arginine and ornithine N(2)-succinyltransferase activity" RELATED [EC:2.3.1.109]
synonym: "arginine and ornithine N2-succinyltransferase activity" RELATED [EC:2.3.1.109]
synonym: "arginine succinyltransferase activity" RELATED [EC:2.3.1.109]
synonym: "AST activity" RELATED [EC:2.3.1.109]
synonym: "AstA" RELATED [EC:2.3.1.109]
synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" RELATED [EC:2.3.1.109]
synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" RELATED [EC:2.3.1.109]
xref: EC:2.3.1.109
xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN
xref: RHEA:15185
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0008792
name: arginine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H+ = agmatine + CO2." [EC:4.1.1.19, RHEA:17641]
synonym: "L-arginine carboxy-lyase (agmatine-forming)" RELATED [EC:4.1.1.19]
synonym: "L-arginine carboxy-lyase activity" RELATED [EC:4.1.1.19]
synonym: "SpeA" RELATED [EC:4.1.1.19]
xref: EC:4.1.1.19
xref: KEGG_REACTION:R00566
xref: MetaCyc:ARGDECARBOX-RXN
xref: Reactome:R-HSA-350598 "Arginine<=>Agmatine+CO2"
xref: RHEA:17641
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008793
name: aromatic-amino-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-alpha aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [RHEA:17533]
synonym: "ArAT" RELATED [EC:2.6.1.57]
synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57]
synonym: "aromatic amino acid transferase activity" EXACT []
synonym: "aromatic aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid:2-oxoglutarate aminotransferase activity" EXACT []
xref: MetaCyc:2.6.1.57-RXN
xref: RHEA:17533
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008794
name: arsenate reductase (glutaredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884]
synonym: "glutharedoxin:arsenate oxidoreductase activity" RELATED [EC:1.20.4.1]
xref: EC:1.20.4.1
xref: MetaCyc:RXN-982
xref: RHEA:22016
xref: UM-BBD_reactionID:r0635
is_a: GO:0030611 ! arsenate reductase activity
is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor

[Term]
id: GO:0008795
name: NAD+ synthase activity
namespace: molecular_function
alt_id: GO:0008749
alt_id: GO:0016965
def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5]
synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" RELATED [EC:6.3.1.5]
synonym: "diphosphopyridine nucleotide synthetase activity" RELATED [EC:6.3.1.5]
synonym: "NAD synthase (AMP-forming)" EXACT []
synonym: "NAD synthase activity" EXACT []
synonym: "NAD synthetase activity" RELATED [EC:6.3.1.5]
synonym: "NAD(+) synthetase activity" RELATED [EC:6.3.1.5]
synonym: "NAD+ synthetase activity" RELATED [EC:6.3.1.5]
synonym: "nicotinamide adenine dinucleotide synthetase activity" RELATED [EC:6.3.1.5]
xref: EC:6.3.1.5
xref: MetaCyc:NAD-SYNTH-NH3-RXN
xref: RHEA:21188
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0008796
name: bis(5'-nucleosyl)-tetraphosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai]
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008797
name: aspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1]
synonym: "aspartase activity" RELATED [EC:4.3.1.1]
synonym: "fumaric aminase activity" RELATED [EC:4.3.1.1]
synonym: "L-aspartase activity" RELATED [EC:4.3.1.1]
synonym: "L-aspartate ammonia-lyase (fumarate-forming)" RELATED [EC:4.3.1.1]
synonym: "L-aspartate ammonia-lyase activity" RELATED [EC:4.3.1.1]
xref: EC:4.3.1.1
xref: MetaCyc:ASPARTASE-RXN
xref: RHEA:16601
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008798
name: beta-aspartyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5]
synonym: "beta-aspartyl dipeptidase activity" RELATED [EC:3.4.19.5]
synonym: "beta-aspartyl peptidase activity" RELATED [EC:3.4.19.5]
xref: EC:3.4.19.5
xref: MetaCyc:3.4.19.5-RXN
xref: Reactome:R-HSA-5692495 "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)"
xref: Reactome:R-HSA-5696365 "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe"
is_a: GO:0008242 ! omega peptidase activity
is_a: GO:0070003 ! threonine-type peptidase activity

[Term]
id: GO:0008800
name: beta-lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6]
synonym: "ampicillinase activity" RELATED [EC:3.5.2.6]
synonym: "beta-lactam hydrolase activity" RELATED [EC:3.5.2.6]
synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6]
synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6]
synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6]
synonym: "cephalosporin-beta-lactamase activity" RELATED [EC:3.5.2.6]
synonym: "exopenicillinase activity" RELATED [EC:3.5.2.6]
synonym: "neutrapen" RELATED [EC:3.5.2.6]
synonym: "penicillin amido-beta-lactamhydrolase activity" RELATED [EC:3.5.2.6]
synonym: "penicillin beta-lactamase activity" RELATED [EC:3.5.2.6]
synonym: "penicillinase I, II" RELATED [EC:3.5.2.6]
xref: EC:3.5.2.6
xref: MetaCyc:BETA-LACTAMASE-RXN
xref: RHEA:20401
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0008801
name: beta-phosphoglucomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6, RHEA:20113]
synonym: "beta-D-glucose 1,6-phosphomutase activity" RELATED [EC:5.4.2.6]
xref: EC:5.4.2.6
xref: KEGG_REACTION:R02728
xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN
xref: RHEA:20113
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0008802
name: betaine-aldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8]
synonym: "BADH activity" RELATED [EC:1.2.1.8]
synonym: "betaine aldehyde dehydrogenase activity" RELATED [EC:1.2.1.8]
synonym: "betaine aldehyde oxidase activity" RELATED [EC:1.2.1.8]
synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.8]
synonym: "BetB" RELATED [EC:1.2.1.8]
xref: EC:1.2.1.8
xref: MetaCyc:BADH-RXN
xref: Reactome:R-HSA-6797955 "ALDH7A1 oxidises BETALD to BET"
xref: RHEA:15305
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0008803
name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+." [EC:3.6.1.41, RHEA:24252]
synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" RELATED [EC:3.6.1.41]
synonym: "adenosine tetraphosphate phosphodiesterase activity" RELATED [EC:3.6.1.41]
synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41]
synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41]
synonym: "bis(5'-adenosyl) tetraphosphatase activity" RELATED [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" RELATED [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" RELATED [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" RELATED [EC:3.6.1.41]
synonym: "diadenosine polyphosphate hydrolase activity" RELATED [EC:3.6.1.41]
synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW []
synonym: "diadenosine tetraphosphate hydrolase activity" RELATED [EC:3.6.1.41]
synonym: "diadenosinetetraphosphatase (symmetrical) activity" RELATED [EC:3.6.1.41]
synonym: "dinucleosidetetraphosphatase (symmetrical) activity" RELATED [EC:3.6.1.41]
synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41]
synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" RELATED [EC:3.6.1.41]
synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" RELATED [EC:3.6.1.41]
xref: EC:3.6.1.41
xref: KEGG_REACTION:R00125
xref: MetaCyc:3.6.1.41-RXN
xref: RHEA:24252
is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity

[Term]
id: GO:0008804
name: carbamate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2]
synonym: "ATP:carbamate phosphotransferase activity" RELATED [EC:2.7.2.2]
synonym: "carbamoyl phosphokinase activity" RELATED [EC:2.7.2.2]
synonym: "carbamyl phosphokinase activity" RELATED [EC:2.7.2.2]
synonym: "CKase activity" RELATED [EC:2.7.2.2]
xref: EC:2.7.2.2
xref: MetaCyc:CARBAMATE-KINASE-RXN
xref: RHEA:10152
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008805
name: carbon-monoxide oxygenase activity
namespace: molecular_function
alt_id: GO:0018999
alt_id: GO:0047767
def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [GOC:curators, RHEA:48880]
synonym: "carbon monoxide oxidase activity" RELATED []
synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW []
synonym: "carbon monoxide oxygenase activity" EXACT []
synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" RELATED []
synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW []
synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" RELATED []
synonym: "cytochrome b561" NARROW []
xref: EC:1.2.5.3
xref: MetaCyc:RXN-21452
xref: RHEA:48880
xref: UM-BBD_reactionID:r0650
xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561)
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0008806
name: carboxymethylenebutenolidase activity
namespace: molecular_function
alt_id: GO:0018735
def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45]
synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" RELATED [EC:3.1.1.45]
synonym: "carboxymethylene butenolide hydrolase activity" RELATED [EC:3.1.1.45]
synonym: "dienelactone hydrolase activity" RELATED [EC:3.1.1.45]
synonym: "maleylacetate enol-lactonase activity" RELATED [EC:3.1.1.45]
xref: EC:3.1.1.45
xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN
xref: RHEA:12372
xref: UM-BBD_enzymeID:r0110
xref: UM-BBD_enzymeID:r0286
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0008807
name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23]
synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" RELATED [EC:2.7.8.23]
synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" RELATED [EC:2.7.8.23]
synonym: "CPEP phosphonomutase activity" RELATED [EC:2.7.8.23]
xref: EC:2.7.8.23
xref: MetaCyc:2.7.8.23-RXN
xref: RHEA:14045
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008808
name: cardiolipin synthase activity
namespace: molecular_function
alt_id: GO:0043788
def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl, RHEA:31451]
synonym: "cardiolipin synthase 2 activity" RELATED []
synonym: "cardiolipin synthetase 2 activity" RELATED []
synonym: "cardiolipin synthetase activity" BROAD []
synonym: "diphosphatidylglycerol synthase activity" EXACT []
xref: MetaCyc:CARDIOLIPSYN-RXN
xref: RHEA:31451
is_a: GO:0030572 ! phosphatidyltransferase activity

[Term]
id: GO:0008809
name: carnitine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN]
xref: MetaCyc:CARNRACE-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0008810
name: cellulase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4]
synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.4]
synonym: "9.5 cellulase activity" RELATED [EC:3.2.1.4]
synonym: "alkali cellulase activity" NARROW [EC:3.2.1.4]
synonym: "avicelase activity" RELATED [EC:3.2.1.4]
synonym: "beta-1,4-endoglucan hydrolase activity" BROAD [EC:3.2.1.4]
synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4]
synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4]
synonym: "celluase A" RELATED [EC:3.2.1.4]
synonym: "celludextrinase activity" RELATED [EC:3.2.1.4]
synonym: "cellulase A 3" RELATED [EC:3.2.1.4]
synonym: "cellulosin AP" RELATED [EC:3.2.1.4]
synonym: "endo-1,4-beta-D-glucanase activity" BROAD [EC:3.2.1.4]
synonym: "endo-1,4-beta-D-glucanohydrolase activity" BROAD [EC:3.2.1.4]
synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.4]
synonym: "endoglucanase activity" BROAD [EC:3.2.1.4]
synonym: "endoglucanase D" RELATED [EC:3.2.1.4]
synonym: "pancellase SS" RELATED [EC:3.2.1.4]
xref: EC:3.2.1.4
xref: MetaCyc:RXN-2043
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0008811
name: chloramphenicol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA." [EC:2.3.1.28, RHEA:18421]
synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" RELATED [EC:2.3.1.28]
synonym: "CAT I" RELATED [EC:2.3.1.28]
synonym: "CAT II" RELATED [EC:2.3.1.28]
synonym: "CAT III" RELATED [EC:2.3.1.28]
synonym: "chloramphenicol acetylase activity" RELATED [EC:2.3.1.28]
synonym: "chloramphenicol acetyltransferase activity" RELATED [EC:2.3.1.28]
synonym: "chloramphenicol transacetylase activity" RELATED [EC:2.3.1.28]
xref: EC:2.3.1.28
xref: KEGG_REACTION:R03065
xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN
xref: RHEA:18421
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008812
name: choline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17433]
synonym: "choline oxidase activity" BROAD [EC:1.1.99.1]
synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1]
synonym: "choline:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.1]
synonym: "choline:(acceptor) oxidoreductase activity" RELATED [EC:1.1.99.1]
synonym: "choline:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.1]
xref: EC:1.1.99.1
xref: KEGG_REACTION:R01025
xref: MetaCyc:CHD-RXN
xref: Reactome:R-HSA-6797961 "CHDH oxidises Cho to BETALD"
xref: RHEA:17433
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0008813
name: chorismate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, RHEA:16505]
synonym: "4-hydroxybenzoate synthetase activity" EXACT []
synonym: "chorismate pyruvate lyase activity" EXACT []
synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" RELATED [EC:4.1.3.40]
synonym: "CL" RELATED [EC:4.1.3.40]
synonym: "CPL" RELATED [EC:4.1.3.40]
synonym: "UbiC" RELATED [EC:4.1.3.40]
xref: EC:4.1.3.40
xref: KEGG_REACTION:R01302
xref: MetaCyc:CHORPYRLY-RXN
xref: RHEA:16505
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008814
name: citrate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10]
synonym: "acetyl-CoA:citrate CoA-transferase activity" RELATED [EC:2.8.3.10]
xref: EC:2.8.3.10
xref: MetaCyc:CITTRANS-RXN
xref: RHEA:19405
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008815
name: citrate (pro-3S)-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [RHEA:10760]
synonym: "citrase activity" RELATED [EC:4.1.3.6]
synonym: "citratase activity" RELATED [EC:4.1.3.6]
synonym: "citrate aldolase activity" RELATED [EC:4.1.3.6]
synonym: "citrate lyase" NARROW []
synonym: "citrate lyase activity" EXACT []
synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6]
synonym: "citrate oxaloacetate-lyase activity" RELATED [EC:4.1.3.6]
synonym: "citric aldolase activity" RELATED [EC:4.1.3.6]
synonym: "citridesmolase activity" RELATED [EC:4.1.3.6]
synonym: "citritase activity" RELATED [EC:4.1.3.6]
xref: EC:4.1.3.6
xref: KEGG_REACTION:R00362
xref: MetaCyc:CITLY-RXN
xref: RHEA:10760
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008816
name: citryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34]
synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.34]
synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" RELATED [EC:4.1.3.34]
xref: EC:4.1.3.34
xref: MetaCyc:CITRYLY-RXN
xref: RHEA:20812
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008817
name: corrinoid adenosyltransferase activity
namespace: molecular_function
alt_id: GO:0043784
def: "Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin." [PMID:19933577, PMID:5946606]
synonym: "aquacob(I)alamin adenosyltransferase activity" NARROW [EC:2.5.1.17]
synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" NARROW [EC:2.5.1.17]
synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" NARROW [EC:2.5.1.17]
synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" RELATED [EC:2.5.1.17]
synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" NARROW [EC:2.5.1.17]
synonym: "ATP:corrinoid adenosyltransferase activity" RELATED [EC:2.5.1.17]
synonym: "cob(I)alamin adenosyltransferase activity" NARROW []
synonym: "cob(I)yrinic acid a,c-diamide adenosyltransferase activity" NARROW []
synonym: "cob(II)yrinic acid a,c-diamide reductase activity" NARROW []
synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" NARROW []
synonym: "vitamin B12s adenosyltransferase activity" RELATED []
xref: EC:2.5.1.17
xref: KEGG_REACTION:R05218
xref: Reactome:R-HSA-3159253 "MMAB adenosylates cob(I)alamin"
xref: Reactome:R-HSA-3322125 "Defective MMAB does not transfer adenosyl group from ATP to B12s"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008818
name: cobalamin 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN]
xref: MetaCyc:COBALAMIN5PSYN-RXN
xref: RHEA:23560
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008819
name: obsolete cobinamide kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [PMID:1655696]
comment: The reason for obsoletion is that this term is equivalent to GO:0043752 adenosylcobinamide kinase activity.
is_obsolete: true
replaced_by: GO:0043752

[Term]
id: GO:0008820
name: cobinamide phosphate guanylyltransferase activity
namespace: molecular_function
alt_id: GO:0043753
def: "Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate." [RHEA:22712]
synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD []
synonym: "adenosylcobinamide-phosphate guanylyltransferase activity" EXACT []
synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD []
synonym: "CobU" RELATED []
synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT []
synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT []
xref: EC:2.7.7.62
xref: KEGG_REACTION:R05222
xref: MetaCyc:COBINPGUANYLYLTRANS-RXN
xref: RHEA:22712
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0008821
name: crossover junction DNA endonuclease activity
namespace: molecular_function
alt_id: GO:0008844
def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.21.10]
synonym: "crossover junction endodeoxyribonuclease activity" EXACT []
synonym: "crossover junction endoribonuclease activity" EXACT []
synonym: "cruciform-cutting endonuclease activity" RELATED [EC:3.1.21.10]
synonym: "endo X3" RELATED [EC:3.1.21.10]
synonym: "endodeoxyribonuclease RUS activity" EXACT []
synonym: "endonuclease RuvC activity" NARROW [EC:3.1.21.10]
synonym: "endonuclease VII activity" NARROW [EC:3.1.21.10]
synonym: "endonuclease X3 activity" NARROW [EC:3.1.21.10]
synonym: "Hje endonuclease activity" RELATED [EC:3.1.21.10]
synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.21.10]
synonym: "Holliday junction nuclease activity" RELATED [EC:3.1.21.10]
synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.21.10]
synonym: "RusA endonuclease activity" NARROW [EC:3.1.21.10]
synonym: "RuvC endonuclease activity" NARROW [EC:3.1.21.10]
synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.21.10]
synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.21.10]
xref: EC:3.1.21.10
xref: MetaCyc:3.1.22.4-RXN
is_a: GO:0016889 ! DNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0008822
name: obsolete crotonobetaine/carnitine-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a bifunctional gene product.
synonym: "crotonobetaine/carnitine-CoA ligase activity" EXACT []
is_obsolete: true
consider: GO:0051108
consider: GO:0051109

[Term]
id: GO:0008823
name: cupric reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Cu2+ + NADH = 2 Cu+ + H+ + NAD+." [PMID:10510271, RHEA:66848]
xref: MetaCyc:R170-RXN
xref: RHEA:66848
is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[Term]
id: GO:0008824
name: cyanate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanate + H2O = carbamate." [EC:4.2.1.104, RHEA:11120]
synonym: "carbamate hydro-lyase activity" RELATED [EC:4.2.1.104]
synonym: "cyanase activity" EXACT []
synonym: "cyanate aminohydrolase activity" RELATED [EC:4.2.1.104]
synonym: "cyanate C-N-lyase activity" RELATED [EC:4.2.1.104]
synonym: "cyanate hydrolase activity" RELATED [EC:4.2.1.104]
synonym: "cyanate lyase activity" EXACT []
xref: EC:4.2.1.104
xref: MetaCyc:R524-RXN
xref: RHEA:11120
xref: UM-BBD_reactionID:r0608
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0008825
name: cyclopropane-fatty-acyl-phospholipid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79]
synonym: "CFA synthase activity" RELATED [EC:2.1.1.79]
synonym: "cyclopropane fatty acid synthase activity" RELATED [EC:2.1.1.79]
synonym: "cyclopropane fatty acid synthetase activity" RELATED [EC:2.1.1.79]
synonym: "cyclopropane synthase activity" RELATED [EC:2.1.1.79]
synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79]
synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" RELATED [EC:2.1.1.79]
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79]
xref: EC:2.1.1.79
xref: MetaCyc:2.1.1.79-RXN
xref: RHEA:11988
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008826
name: cysteine sulfinate desulfinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [RHEA:28278]
synonym: "cysteine sulphinate desulphinase activity" EXACT []
xref: MetaCyc:RXN0-279
xref: RHEA:28278
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0008828
name: dATP diphosphatase activity
namespace: molecular_function
alt_id: GO:0044713
alt_id: GO:0044714
def: "Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate." [GOC:pde, PMID:11139615, RHEA:28334]
synonym: "2-hydroxy-(d)ATP pyrophosphatase activity" EXACT []
synonym: "2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity" EXACT []
synonym: "2-hydroxy-adenosine triphosphate pyrophosphatase activity" RELATED []
synonym: "2-hydroxy-ATP pyrophosphatase activity" RELATED []
synonym: "dATP pyrophosphohydrolase activity" EXACT []
xref: EC:3.6.1.56
xref: MetaCyc:RXN0-384
xref: RHEA:28334
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0008829
name: dCTP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13]
synonym: "5-methyl-dCTP deaminase activity" RELATED [EC:3.5.4.13]
synonym: "dCTP aminohydrolase activity" RELATED [EC:3.5.4.13]
synonym: "deoxycytidine triphosphate deaminase activity" RELATED [EC:3.5.4.13]
xref: EC:3.5.4.13
xref: MetaCyc:DCTP-DEAM-RXN
xref: Reactome:R-HSA-180632 "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand"
xref: RHEA:22680
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008830
name: dTDP-4-dehydrorhamnose 3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16969]
synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" RELATED [EC:5.1.3.13]
synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" RELATED [EC:5.1.3.13]
synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" RELATED [EC:5.1.3.13]
synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13]
synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13]
xref: EC:5.1.3.13
xref: KEGG_REACTION:R06514
xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN
xref: RHEA:16969
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008831
name: dTDP-4-dehydrorhamnose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH." [EC:1.1.1.133, RHEA:21796]
synonym: "dTDP-4-keto-L-rhamnose reductase activity" RELATED [EC:1.1.1.133]
synonym: "dTDP-4-ketorhamnose reductase activity" RELATED [EC:1.1.1.133]
synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" RELATED [EC:1.1.1.133]
synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.133]
synonym: "reductase, thymidine diphospho-4-ketorhamnose" RELATED [EC:1.1.1.133]
synonym: "TDP-4-keto-rhamnose reductase activity" RELATED [EC:1.1.1.133]
synonym: "thymidine diphospho-4-ketorhamnose reductase activity" RELATED [EC:1.1.1.133]
xref: EC:1.1.1.133
xref: KEGG_REACTION:R02777
xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN
xref: RHEA:21796
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008832
name: dGTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate." [RHEA:15193]
synonym: "deoxy-GTPase activity" RELATED [EC:3.1.5.1]
synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" RELATED [EC:3.1.5.1]
synonym: "deoxyguanosine triphosphatase activity" RELATED [EC:3.1.5.1]
synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" RELATED [EC:3.1.5.1]
synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT []
synonym: "dGTP triphosphohydrolase activity" RELATED [EC:3.1.5.1]
xref: EC:3.1.5.1
xref: KEGG_REACTION:R01856
xref: MetaCyc:DGTPTRIPHYDRO-RXN
xref: RHEA:15193
is_a: GO:0016793 ! triphosphoric monoester hydrolase activity

[Term]
id: GO:0008833
name: deoxyribonuclease IV (phage-T4-induced) activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2]
synonym: "deoxriboendonuclease activity" RELATED [EC:3.1.21.2]
synonym: "deoxyribonuclease IV (phage T4-induced) activity" RELATED [EC:3.1.21.2]
synonym: "DNA-adenine-transferase activity" RELATED [EC:3.1.21.2]
synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2]
synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" RELATED [EC:3.1.21.2]
synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" RELATED [EC:3.1.21.2]
synonym: "endonuclease II" RELATED [EC:3.1.21.2]
synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2]
synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2]
synonym: "redoxyendonuclease activity" RELATED [EC:3.1.21.2]
xref: EC:3.1.21.2
xref: MetaCyc:RXN-20410
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008834
name: ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate." [RHEA:27551]
synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31]
synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" RELATED [EC:2.5.1.31]
synonym: "di-trans,poly-cis-decaprenylcistransferase activity" EXACT []
synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl diphosphate synthase activity" EXACT []
synonym: "undecaprenyl diphosphate synthetase activity" RELATED [EC:2.5.1.31]
synonym: "undecaprenyl pyrophosphate synthase activity" RELATED [EC:2.5.1.31]
synonym: "undecaprenyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.31]
synonym: "undecaprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31]
synonym: "UPP synthetase activity" RELATED [EC:2.5.1.31]
xref: EC:2.5.1.31
xref: MetaCyc:RXN-8999
xref: RHEA:27551
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0008835
name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
namespace: molecular_function
alt_id: GO:0008485
def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4." [EC:3.5.4.26, PMID:11889103, RHEA:21868]
synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT []
synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" RELATED [EC:3.5.4.26]
synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" RELATED [EC:3.5.4.26]
xref: EC:3.5.4.26
xref: KEGG_REACTION:R03459
xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN
xref: RHEA:21868
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008836
name: diaminopimelate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2." [EC:4.1.1.20, RHEA:15101]
synonym: "DAP decarboxylase activity" RELATED [EC:4.1.1.20]
synonym: "DAP-decarboxylase activity" RELATED [EC:4.1.1.20]
synonym: "diaminopimelic acid decarboxylase activity" RELATED [EC:4.1.1.20]
synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" RELATED [EC:4.1.1.20]
synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" RELATED [EC:4.1.1.20]
synonym: "meso-diaminopimelate decarboxylase activity" RELATED [EC:4.1.1.20]
xref: EC:4.1.1.20
xref: KEGG_REACTION:R00451
xref: MetaCyc:DIAMINOPIMDECARB-RXN
xref: RHEA:15101
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008837
name: diaminopimelate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate." [EC:5.1.1.7, RHEA:15393]
synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" RELATED [EC:5.1.1.7]
xref: EC:5.1.1.7
xref: KEGG_REACTION:R02735
xref: MetaCyc:DIAMINOPIMEPIM-RXN
xref: RHEA:15393
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008838
name: diaminopropionate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15]
synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" RELATED [EC:4.3.1.15]
synonym: "2,3-diaminopropionate ammonia-lyase activity" RELATED [EC:4.3.1.15]
synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" RELATED [EC:4.3.1.15]
synonym: "diaminopropionatase activity" RELATED [EC:4.3.1.15]
xref: EC:4.3.1.15
xref: MetaCyc:4.3.1.15-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008839
name: 4-hydroxy-tetrahydrodipicolinate reductase
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8]
synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.17.1.8]
synonym: "dihydrodipicolinate reductase activity" EXACT []
synonym: "dihydrodipicolinic acid reductase activity" RELATED [EC:1.17.1.8]
xref: EC:1.17.1.8
xref: MetaCyc:RXN-14014
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008840
name: 4-hydroxy-tetrahydrodipicolinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O." [PMID:8993314, RHEA:34171]
synonym: "DHDPS activity" RELATED [EC:4.3.3.7]
synonym: "dihydrodipicolinate synthase activity" EXACT []
synonym: "dihydrodipicolinate synthetase activity" RELATED [EC:4.3.3.7]
synonym: "dihydrodipicolinic acid synthase activity" RELATED [EC:4.3.3.7]
synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" RELATED []
synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED []
xref: EC:4.3.3.7
xref: KEGG_REACTION:R02292
xref: MetaCyc:DIHYDRODIPICSYN-RXN
xref: RHEA:34171
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008841
name: dihydrofolate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12]
synonym: "7,8-dihydrofolate synthetase activity" RELATED [EC:6.3.2.12]
synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" RELATED [EC:6.3.2.12]
synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" RELATED [EC:6.3.2.12]
synonym: "DHFS activity" RELATED [EC:6.3.2.12]
synonym: "dihydrofolate synthetase activity" RELATED [EC:6.3.2.12]
synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" RELATED [EC:6.3.2.12]
synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" RELATED [EC:6.3.2.12]
synonym: "FHFS activity" RELATED [EC:6.3.2.12]
synonym: "FHFS/FPGS activity" RELATED [EC:6.3.2.12]
synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" RELATED [EC:6.3.2.12]
synonym: "H(2)-folate synthetase activity" RELATED [EC:6.3.2.12]
synonym: "H2-folate synthetase activity" RELATED [EC:6.3.2.12]
xref: EC:6.3.2.12
xref: MetaCyc:DIHYDROFOLATESYNTH-RXN
xref: RHEA:23584
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008842
name: diphosphate-purine nucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143]
synonym: "diphosphate-dependent nucleoside kinase activity" RELATED [EC:2.7.1.143]
synonym: "diphosphate:purine nucleoside phosphotransferase activity" RELATED [EC:2.7.1.143]
synonym: "pyrophosphate-dependent nucleoside kinase activity" RELATED [EC:2.7.1.143]
synonym: "pyrophosphate-purine nucleoside kinase activity" RELATED [EC:2.7.1.143]
xref: EC:2.7.1.143
xref: MetaCyc:2.7.1.143-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0008843
name: endochitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
synonym: "1,4-beta-poly-N-acetylglucosaminidase" EXACT [EC:3.2.1.14]
synonym: "chitinase" EXACT [EC:3.2.1.14]
synonym: "chitodextrinase" EXACT [EC:3.2.1.14]
synonym: "poly-beta-glucosaminidase" EXACT [EC:3.2.1.14]
xref: EC:3.2.1.14
xref: MetaCyc:3.2.1.14-RXN
is_a: GO:0004568 ! chitinase activity

[Term]
id: GO:0008845
name: obsolete endonuclease VIII activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [PMID:12713806]
comment: This term was made obsolete because it represents a gene product.
synonym: "endonuclease VIII activity" EXACT []
is_obsolete: true
consider: GO:0000703
consider: GO:0003684
consider: GO:0003906
consider: GO:0004519
consider: GO:0008081
consider: GO:0019104

[Term]
id: GO:0008846
name: obsolete endopeptidase La activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP-dependent lon proteinase" NARROW []
synonym: "ATP-dependent protease La activity" RELATED []
synonym: "ATP-dependent serine proteinase activity" RELATED []
synonym: "endopeptidase La activity" EXACT []
synonym: "Escherichia coli proteinase La" RELATED []
synonym: "Escherichia coli serine proteinase La" RELATED []
synonym: "gene lon protease activity" RELATED []
synonym: "gene lon proteins" RELATED []
synonym: "lon proteinase" NARROW []
synonym: "PIM1 protease activity" RELATED []
synonym: "PIM1 proteinase activity" RELATED []
synonym: "protease La" RELATED []
synonym: "proteinase La" RELATED []
synonym: "serine protease La" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008847
name: Enterobacter ribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.21]
synonym: "Enterobacter RNase activity" EXACT []
xref: EC:4.6.1.21
xref: MetaCyc:3.1.27.6-RXN
is_a: GO:0016892 ! RNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0008848
name: obsolete enterobactin synthetase
namespace: molecular_function
alt_id: GO:0008850
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a process rather than a function.
synonym: "enterobactin synthetase" EXACT []
synonym: "enterochelin synthetase activity" EXACT []
synonym: "nonribosomal peptide synthetase" RELATED []
is_obsolete: true
replaced_by: GO:0009239

[Term]
id: GO:0008849
name: enterochelin esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+." [MetaCyc:RXN0-1661, PMID:4565531]
synonym: "enterobactin esterase activity" EXACT []
xref: MetaCyc:RXN0-1661
xref: RHEA:28018
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0008851
name: ethanolamine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7]
synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" RELATED [EC:4.3.1.7]
synonym: "ethanolamine deaminase activity" RELATED [EC:4.3.1.7]
xref: EC:4.3.1.7
xref: MetaCyc:ETHAMLY-RXN
xref: RHEA:15313
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008852
name: obsolete exodeoxyribonuclease I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [GOC:curators]
comment: This term was obsoleted because it is the same function as single-stranded DNA 3'-5' exodeoxyribonuclease activity ; GO:0008310.
is_obsolete: true
replaced_by: GO:0008310

[Term]
id: GO:0008853
name: obsolete exodeoxyribonuclease III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [GOC:curators]
comment: This term was obsoleted because it is the same function as double-stranded DNA 3'-5' exodeoxyribonuclease activity ; GO:0008311.
is_obsolete: true
replaced_by: GO:0008311

[Term]
id: GO:0008854
name: exodeoxyribonuclease V activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5]
synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5]
synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5]
synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5]
synonym: "exonuclease V activity" RELATED [EC:3.1.11.5]
synonym: "gene recBC DNase activity" RELATED [EC:3.1.11.5]
synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5]
synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5]
synonym: "RecBC deoxyribonuclease activity" RELATED [EC:3.1.11.5]
xref: EC:3.1.11.5
xref: MetaCyc:RXN0-2605
is_a: GO:0016895 ! DNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008855
name: exodeoxyribonuclease VII activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6]
synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6]
synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6]
synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6]
synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6]
synonym: "exonuclease VII activity" RELATED [EC:3.1.11.6]
xref: EC:3.1.11.6
xref: MetaCyc:3.1.11.6-RXN
is_a: GO:0016895 ! DNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008856
name: obsolete exodeoxyribonuclease X activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this function exists.
is_obsolete: true

[Term]
id: GO:0008859
name: exoribonuclease II activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1]
synonym: "5'-exoribonuclease activity" RELATED [EC:3.1.13.1]
synonym: "BN ribonuclease activity" RELATED [EC:3.1.13.1]
synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1]
synonym: "ribonuclease II activity" RELATED [EC:3.1.13.1]
synonym: "ribonuclease Q" RELATED [EC:3.1.13.1]
synonym: "RNase II" RELATED [EC:3.1.13.1]
synonym: "RNase II activity" EXACT []
xref: EC:3.1.13.1
xref: MetaCyc:3.1.13.1-RXN
is_a: GO:0000175 ! 3'-5'-RNA exonuclease activity

[Term]
id: GO:0008860
name: ferredoxin-NAD+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [RHEA:16521]
synonym: "ferredoxin-linked NAD reductase activity" RELATED [EC:1.18.1.3]
synonym: "ferredoxin-NAD reductase activity" EXACT []
synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" RELATED [EC:1.18.1.3]
synonym: "ferredoxin:NAD+ oxidoreductase activity" RELATED [EC:1.18.1.3]
synonym: "NAD-ferredoxin reductase activity" RELATED [EC:1.18.1.3]
synonym: "NADH flavodoxin oxidoreductase activity" RELATED [EC:1.18.1.3]
synonym: "NADH-ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.3]
synonym: "NADH-ferredoxin reductase activity" RELATED [EC:1.18.1.3]
synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" RELATED [EC:1.18.1.3]
synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" RELATED [EC:1.18.1.3]
synonym: "NADH2-ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.3]
synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" RELATED [EC:1.18.1.3]
xref: EC:1.18.1.3
xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN
xref: RHEA:16521
is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity

[Term]
id: GO:0008861
name: formate C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [RHEA:11844]
synonym: "formate acetyltransferase activity" RELATED [EC:2.3.1.54]
synonym: "PFL" EXACT []
xref: EC:2.3.1.54
xref: MetaCyc:PYRUVFORMLY-RXN
xref: RHEA:11844
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0008863
name: formate dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0018476
def: "Catalysis of the reaction: formate + NAD+ = CO2 + NADH." [EC:1.17.1.9, RHEA:15985]
synonym: "formate dehydrogenase (NAD)" RELATED [EC:1.17.1.9]
synonym: "formate hydrogenlyase" RELATED [EC:1.17.1.9]
synonym: "formate-NAD oxidoreductase" RELATED []
synonym: "formic acid dehydrogenase" RELATED [EC:1.17.1.9]
synonym: "formic hydrogen-lyase" RELATED [EC:1.17.1.9]
synonym: "NAD-dependent formate dehydrogenase" RELATED []
synonym: "NAD-formate dehydrogenase" RELATED [EC:1.17.1.9]
xref: EC:1.17.1.9
xref: KEGG_REACTION:R00519
xref: MetaCyc:1.2.1.2-RXN
xref: RHEA:15985
xref: UM-BBD_reactionID:r0103
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008864
name: formyltetrahydrofolate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+." [EC:3.5.1.10, RHEA:19833]
synonym: "10-formyltetrahydrofolate amidohydrolase activity" RELATED [EC:3.5.1.10]
synonym: "formyl-FH(4) hydrolase activity" RELATED [EC:3.5.1.10]
synonym: "formyltetrahydrofolate hydrolase activity" RELATED [EC:3.5.1.10]
xref: EC:3.5.1.10
xref: KEGG_REACTION:R00944
xref: MetaCyc:FORMYLTHFDEFORMYL-RXN
xref: RHEA:19833
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008865
name: fructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4]
synonym: "ATP:D-fructose 6-phosphotransferase activity" RELATED [EC:2.7.1.4]
synonym: "D-fructokinase activity" RELATED [EC:2.7.1.4]
synonym: "D-fructose(D-mannose)kinase activity" RELATED [EC:2.7.1.4]
synonym: "fructokinase (phosphorylating)" RELATED [EC:2.7.1.4]
xref: EC:2.7.1.4
xref: MetaCyc:FRUCTOKINASE-RXN
xref: RHEA:16125
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0008866
name: fructuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH." [EC:1.1.1.57, RHEA:15729]
synonym: "D-mannonate dehydrogenase activity" RELATED [EC:1.1.1.57]
synonym: "D-mannonate oxidoreductase activity" RELATED [EC:1.1.1.57]
synonym: "D-mannonate:NAD oxidoreductase activity" RELATED [EC:1.1.1.57]
synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" RELATED [EC:1.1.1.57]
synonym: "mannonate oxidoreductase activity" RELATED [EC:1.1.1.57]
synonym: "mannonic dehydrogenase activity" RELATED [EC:1.1.1.57]
xref: EC:1.1.1.57
xref: KEGG_REACTION:R02454
xref: MetaCyc:MANNONOXIDOREDUCT-RXN
xref: RHEA:15729
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008867
name: galactarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.42, RHEA:16005]
synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" RELATED [EC:4.2.1.42]
synonym: "D-galactarate hydro-lyase activity" RELATED [EC:4.2.1.42]
xref: EC:4.2.1.42
xref: KEGG_REACTION:R05608
xref: MetaCyc:GALACTARDEHYDRA-RXN
xref: RHEA:16005
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008868
name: galactitol-1-phosphate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251]
synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.251]
xref: EC:1.1.1.251
xref: MetaCyc:1.1.1.251-RXN
xref: RHEA:15137
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008869
name: galactonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O." [EC:4.2.1.6, RHEA:18649]
synonym: "D-galactonate dehydrase activity" RELATED [EC:4.2.1.6]
synonym: "D-galactonate dehydratase activity" RELATED [EC:4.2.1.6]
synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" RELATED [EC:4.2.1.6]
synonym: "D-galactonate hydro-lyase activity" RELATED [EC:4.2.1.6]
xref: EC:4.2.1.6
xref: KEGG_REACTION:R03033
xref: MetaCyc:GALACTONDEHYDRAT-RXN
xref: RHEA:18649
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008870
name: galactoside O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18]
synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" RELATED [EC:2.3.1.18]
synonym: "galactoside acetyltransferase activity" RELATED [EC:2.3.1.18]
synonym: "thiogalactoside acetyltransferase activity" RELATED [EC:2.3.1.18]
synonym: "thiogalactoside transacetylase activity" RELATED [EC:2.3.1.18]
xref: EC:2.3.1.18
xref: MetaCyc:GALACTOACETYLTRAN-RXN
xref: RHEA:15713
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008871
name: aminoglycoside 2''-nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb]
synonym: "2''-aminoglycoside nucleotidyltransferase activity" RELATED [EC:2.7.7.46]
synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
xref: EC:2.7.7.46
xref: MetaCyc:2.7.7.46-RXN
is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity

[Term]
id: GO:0008872
name: glucarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40]
synonym: "D-glucarate dehydratase activity" RELATED [EC:4.2.1.40]
synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" RELATED [EC:4.2.1.40]
synonym: "D-glucarate hydro-lyase activity" RELATED [EC:4.2.1.40]
xref: EC:4.2.1.40
xref: MetaCyc:GLUCARDEHYDRA-RXN
xref: RHEA:14573
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008873
name: gluconate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215]
synonym: "2-keto-D-gluconate reductase activity" RELATED [EC:1.1.1.215]
synonym: "2-ketogluconate reductase activity" RELATED [EC:1.1.1.215]
xref: EC:1.1.1.215
xref: MetaCyc:1.1.1.215-RXN
xref: RHEA:16653
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0008874
name: gluconate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69]
synonym: "5-keto-D-gluconate 5-reductase activity" RELATED [EC:1.1.1.69]
synonym: "5-keto-D-gluconate reductase" RELATED [EC:1.1.1.69]
synonym: "5-ketogluconate 5-reductase activity" RELATED [EC:1.1.1.69]
synonym: "5-ketogluconate reductase activity" RELATED [EC:1.1.1.69]
synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" RELATED [EC:1.1.1.69]
xref: EC:1.1.1.69
xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0008875
name: gluconate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [GOC:curators]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008876
name: quinoprotein glucose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [RHEA:22152]
synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" RELATED [EC:1.1.5.2]
synonym: "D-glucose:ubiquinone oxidoreductase activity" RELATED [EC:1.1.5.2]
synonym: "glucose dehydrogenase (PQQ-dependent) activity" RELATED [EC:1.1.5.2]
synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT []
synonym: "quinoprotein D-glucose dehydrogenase activity" RELATED [EC:1.1.5.2]
xref: EC:1.1.5.2
xref: KEGG_REACTION:R00305
xref: MetaCyc:RXN0-6373
xref: RHEA:22152
is_a: GO:0004344 ! glucose dehydrogenase activity
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0008877
name: glucose-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10]
synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.10]
synonym: "D-glucose-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.10]
xref: EC:3.1.3.10
xref: KEGG_REACTION:R00304
xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN
xref: RHEA:19933
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0008878
name: glucose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate." [EC:2.7.7.27, RHEA:12120]
synonym: "adenosine diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.27]
synonym: "adenosine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.27]
synonym: "ADGase activity" EXACT []
synonym: "ADP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.27]
synonym: "ADP-glucose diphosphorylase activity" RELATED [EC:2.7.7.27]
synonym: "ADP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.27]
synonym: "ADP-glucose synthase activity" RELATED [EC:2.7.7.27]
synonym: "ADP-glucose synthetase activity" RELATED [EC:2.7.7.27]
synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.27]
synonym: "ADPG pyrophosphorylase activity" EXACT []
synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.27]
synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT []
synonym: "glucose 1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.27]
xref: EC:2.7.7.27
xref: KEGG_REACTION:R00948
xref: MetaCyc:GLUC1PADENYLTRANS-RXN
xref: RHEA:12120
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008879
name: glucose-1-phosphate thymidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15225]
synonym: "dTDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.24]
synonym: "dTDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.24]
synonym: "dTDP-glucose synthase activity" RELATED [EC:2.7.7.24]
synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.24]
synonym: "glucose 1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.24]
synonym: "TDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.24]
synonym: "thymidine diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.24]
synonym: "thymidine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.24]
xref: EC:2.7.7.24
xref: KEGG_REACTION:R02328
xref: MetaCyc:DTDPGLUCOSEPP-RXN
xref: RHEA:15225
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0008880
name: glucuronate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate." [EC:5.3.1.12]
synonym: "D-glucuronate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.12]
synonym: "D-glucuronate isomerase activity" RELATED [EC:5.3.1.12]
synonym: "D-glucuronate ketol-isomerase activity" RELATED [EC:5.3.1.12]
synonym: "uronate isomerase activity" RELATED [EC:5.3.1.12]
synonym: "uronic acid isomerase activity" RELATED [EC:5.3.1.12]
synonym: "uronic isomerase activity" RELATED [EC:5.3.1.12]
xref: EC:5.3.1.12
xref: MetaCyc:GLUCUROISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008881
name: glutamate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3, RHEA:12813]
xref: EC:5.1.1.3
xref: KEGG_REACTION:R00260
xref: MetaCyc:GLUTRACE-RXN
xref: RHEA:12813
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008882
name: [glutamate-ammonia-ligase] adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]." [EC:2.7.7.42]
synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" RELATED [EC:2.7.7.42]
synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT []
synonym: "ATP:glutamine synthetase adenylyltransferase activity" RELATED [EC:2.7.7.42]
synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" RELATED [EC:2.7.7.42]
synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT []
synonym: "glutamine-synthetase adenylyltransferase activity" RELATED [EC:2.7.7.42]
xref: EC:2.7.7.42
xref: MetaCyc:GSADENYLATION-RXN
xref: RHEA:18589
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008883
name: glutamyl-tRNA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH." [EC:1.2.1.70, RHEA:12344]
synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" RELATED [EC:1.2.1.70]
xref: EC:1.2.1.70
xref: KEGG_REACTION:R04109
xref: MetaCyc:GLUTRNAREDUCT-RXN
xref: RHEA:12344
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0008884
name: glutathionylspermidine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78]
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" RELATED [EC:3.5.1.78]
synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" RELATED [EC:3.5.1.78]
synonym: "GSP amidase activity" RELATED [EC:3.5.1.78]
xref: EC:3.5.1.78
xref: MetaCyc:GSPAMID-RXN
xref: RHEA:17173
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008885
name: glutathionylspermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8]
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8]
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" RELATED [EC:6.3.1.8]
synonym: "glutathione:spermidine ligase (ADP-forming) activity" RELATED [EC:6.3.1.8]
synonym: "glutathionylspermidine synthetase activity" RELATED [EC:6.3.1.8]
synonym: "GSP synthetase activity" RELATED [EC:6.3.1.8]
xref: EC:6.3.1.8
xref: MetaCyc:GSPSYN-RXN
xref: RHEA:21272
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0008886
name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H2O + NADP+ = 3-phospho-D-glycerate + 2 H+ + NADPH." [EC:1.2.1.9, RHEA:14669]
synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT []
synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD []
synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT []
synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT []
synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT []
synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD []
synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9]
xref: EC:1.2.1.9
xref: KEGG_REACTION:R01058
xref: MetaCyc:1.2.1.9-RXN
xref: RHEA:14669
is_a: GO:0120533 ! glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (non-phosphorylating) activity

[Term]
id: GO:0008887
name: glycerate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+." [EC:2.7.1.31, RHEA:23516]
synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" RELATED [EC:2.7.1.31]
synonym: "ATP:D-glycerate 2-phosphotransferase activity" RELATED [EC:2.7.1.31]
synonym: "D-glycerate 3-kinase activity" RELATED [EC:2.7.1.31]
synonym: "D-glycerate kinase activity" RELATED [EC:2.7.1.31]
synonym: "D-glyceric acid kinase activity" RELATED [EC:2.7.1.31]
synonym: "GK" RELATED [EC:2.7.1.31]
synonym: "glycerate kinase (phosphorylating)" RELATED [EC:2.7.1.31]
synonym: "glycerate-3-kinase activity" RELATED [EC:2.7.1.31]
xref: EC:2.7.1.31
xref: KEGG_REACTION:R01514
xref: MetaCyc:GLY3KIN-RXN
xref: Reactome:R-HSA-6799495 "GLYCTK phosphorylates DGA to 3PDGA"
xref: RHEA:23516
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008888
name: glycerol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NAD+ = glycerone + H+ + NADH." [RHEA:13769]
synonym: "glycerol dehydrogenase activity" BROAD []
synonym: "NAD-linked glycerol dehydrogenase activity" RELATED [EC:1.1.1.6]
xref: EC:1.1.1.6
xref: KEGG_REACTION:R01034
xref: MetaCyc:GLYCDEH-RXN
xref: RHEA:13769
is_a: GO:1990042 ! glycerol dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0008889
name: glycerophosphodiester phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
synonym: "gene hpd protein" RELATED [EC:3.1.4.46]
synonym: "glycerophosphodiester glycerophosphohydrolase activity" RELATED [EC:3.1.4.46]
synonym: "glycerophosphoryl diester phosphodiesterase activity" RELATED [EC:3.1.4.46]
synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46]
xref: EC:3.1.4.46
xref: MetaCyc:GLYCPDIESTER-RXN
xref: Reactome:R-HSA-1483107 "GPETA is hydrolyzed to ETA and G3P by GPCPD1"
xref: Reactome:R-HSA-1483116 "GPCho is hydrolyzed to Cho and G3P by GPCPD1"
xref: RHEA:12969
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0008890
name: glycine C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA." [EC:2.3.1.29, RHEA:20736]
synonym: "glycine acetyltransferase activity" RELATED [EC:2.3.1.29]
xref: EC:2.3.1.29
xref: KEGG_REACTION:R00371
xref: MetaCyc:AKBLIG-RXN
xref: RHEA:20736
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0008892
name: guanine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3]
synonym: "GAH activity" RELATED [EC:3.5.4.3]
synonym: "guanase activity" RELATED [EC:3.5.4.3]
synonym: "guanine aminase activity" RELATED [EC:3.5.4.3]
synonym: "guanine aminohydrolase activity" RELATED [EC:3.5.4.3]
xref: EC:3.5.4.3
xref: MetaCyc:GUANINE-DEAMINASE-RXN
xref: Reactome:R-HSA-74255 "Guanine + H2O => Xanthine + NH4+"
xref: RHEA:14665
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008893
name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+." [RHEA:14253]
synonym: "(ppGpp)ase activity" RELATED [EC:3.1.7.2]
synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT []
synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" RELATED [EC:3.1.7.2]
synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT []
synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" RELATED [EC:3.1.7.2]
synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" RELATED [EC:3.1.7.2]
synonym: "PpGpp phosphohydrolase activity" RELATED [EC:3.1.7.2]
synonym: "PpGpp-3'-pyrophosphohydrolase activity" RELATED [EC:3.1.7.2]
xref: EC:3.1.7.2
xref: MetaCyc:PPGPPSYN-RXN
xref: RHEA:14253
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0008894
name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40]
synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" RELATED [EC:3.6.1.40]
synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" RELATED [EC:3.6.1.40]
synonym: "guanosine pentaphosphatase activity" RELATED [EC:3.6.1.40]
synonym: "guanosine pentaphosphate phosphatase activity" RELATED [EC:3.6.1.40]
synonym: "guanosine pentaphosphate phosphohydrolase activity" RELATED [EC:3.6.1.40]
synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" RELATED [EC:3.6.1.40]
synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT []
synonym: "pppGpp 5'-phosphohydrolase activity" RELATED [EC:3.6.1.40]
xref: EC:3.6.1.40
xref: MetaCyc:PPPGPPHYDRO-RXN
xref: RHEA:13073
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008897
name: holo-[acyl-carrier-protein] synthase activity
namespace: molecular_function
alt_id: GO:0008958
def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]
synonym: "4'-phosphopantetheinyl transferase activity" RELATED [EC:2.7.8.7]
synonym: "4'-phosphopantetheinyltransferase activity" EXACT []
synonym: "AcpS" RELATED [EC:2.7.8.7]
synonym: "ACPS activity" RELATED [EC:2.7.8.7]
synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" RELATED [EC:2.7.8.7]
synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7]
synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7]
synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT []
synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" RELATED [EC:2.7.8.7]
synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" RELATED [EC:2.7.8.7]
synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" RELATED [EC:2.7.8.7]
synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" RELATED [EC:2.7.8.7]
synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" RELATED [EC:2.7.8.7]
synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW []
synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7]
synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7]
synonym: "holo-acyl-carrier-protein synthase activity" RELATED [EC:2.7.8.7]
synonym: "holosynthase activity" RELATED [EC:2.7.8.7]
synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7]
synonym: "P-pant transferase activity" RELATED [EC:2.7.8.7]
synonym: "phosphopantetheinyl transferase" RELATED []
synonym: "phosphopantetheinyltransferase activity" EXACT []
synonym: "PPTase activity" RELATED [EC:2.7.8.7]
xref: EC:2.7.8.7
xref: MetaCyc:HOLO-ACP-SYNTH-RXN
xref: Reactome:R-HSA-199202 "Phosphopantetheine conjugation of the ACP domain of FAS"
xref: RHEA:12068
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008898
name: S-adenosylmethionine-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [RHEA:21820]
synonym: "adenosylmethionine transmethylase activity" RELATED [EC:2.1.1.10]
synonym: "adenosylmethionine:homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10]
synonym: "L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "S-adenosylmethionine homocysteine transmethylase activity" RELATED [EC:2.1.1.10]
synonym: "S-adenosylmethionine-homocysteine transmethylase activity" RELATED [EC:2.1.1.10]
synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN
xref: RHEA:21820
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008899
name: homoserine O-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA." [EC:2.3.1.46, RHEA:22008]
synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46]
synonym: "homoserine succinyltransferase activity" RELATED [EC:2.3.1.46]
synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" RELATED [EC:2.3.1.46]
xref: EC:2.3.1.46
xref: KEGG_REACTION:R01777
xref: MetaCyc:HOMSUCTRAN-RXN
xref: RHEA:22008
is_a: GO:0016750 ! O-succinyltransferase activity

[Term]
id: GO:0008900
name: P-type potassium:proton transporter activity
namespace: molecular_function
alt_id: GO:0005390
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [RHEA:22044]
synonym: "(K+ + H+)-ATPase activity" RELATED [EC:7.2.2.19]
synonym: "ATP phosphohydrolase (H+/K+-exchanging)" RELATED [EC:7.2.2.19]
synonym: "gastric H+/K(+) ATPase activity" NARROW [EC:7.2.2.19]
synonym: "gastric H+/K+ ATPase" NARROW [EC:7.2.2.19]
synonym: "H+-K+-ATPase activity" RELATED [EC:7.2.2.19]
synonym: "H+/K(+)-ATPase activity" RELATED [EC:7.2.2.19]
synonym: "H+/K(+)-exchanging ATPase activity" RELATED [EC:7.2.2.19]
synonym: "H+/K+-ATPase activity" RELATED [EC:7.2.2.19]
synonym: "H+/K+-exchanging ATPase activity" RELATED [EC:7.2.2.19]
synonym: "H,K-ATPase activity" RELATED [EC:7.2.2.19]
synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT []
synonym: "hydrogen:potassium exchanging ATPase activity" EXACT []
synonym: "hydrogen:potassium-exchanging ATPase activity" EXACT []
synonym: "potassium:proton exchanging ATPase activity" RELATED []
synonym: "proton pump activity" BROAD [EC:7.2.2.19]
xref: EC:7.2.2.19
xref: MetaCyc:3.6.3.10-RXN
xref: Reactome:R-HSA-937311 "ATP12A:ATP4B exchanges K+ for H+"
xref: Reactome:R-HSA-9727198 "ATP4A:ATP4B exchanges K+ for H+"
xref: RHEA:22044
is_a: GO:0008553 ! P-type proton-exporting transporter activity
is_a: GO:0008556 ! P-type potassium transmembrane transporter activity

[Term]
id: GO:0008901
name: ferredoxin hydrogenase activity
namespace: molecular_function
alt_id: GO:0016948
alt_id: GO:0016949
alt_id: GO:0016950
alt_id: GO:0016951
def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2]
synonym: "[Fe] hydrogenase activity" EXACT []
synonym: "[Fe] hydrogenase gamma" RELATED []
synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H2 oxidizing hydrogenase" BROAD []
synonym: "H2 producing hydrogenase" BROAD []
synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2]
synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT []
synonym: "hydrogenase (ferredoxin) activity" RELATED [EC:1.12.7.2]
synonym: "hydrogenase activity" BROAD []
synonym: "hydrogenase I" RELATED []
synonym: "hydrogenase II" RELATED []
synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2]
synonym: "iron hydrogenase activity" NARROW []
synonym: "iron-only hydrogenase activity" NARROW []
synonym: "Ni-Fe hydrogenase activity" NARROW []
synonym: "Ni-Fe-Se hydrogenase activity" NARROW []
synonym: "nickel hydrogenase activity" NARROW []
synonym: "nickel-iron hydrogenase activity" NARROW []
synonym: "nickel-iron-selenium hydrogenase activity" NARROW []
synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2]
xref: EC:1.12.7.2
xref: MetaCyc:HYDROG-RXN
xref: RHEA:17445
is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor

[Term]
id: GO:0008902
name: hydroxymethylpyrimidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H+." [EC:2.7.1.49, RHEA:23096]
synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" RELATED [EC:2.7.1.49]
synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" RELATED [EC:2.7.1.49]
xref: EC:2.7.1.49
xref: KEGG_REACTION:R03471
xref: MetaCyc:OHMETPYRKIN-RXN
xref: RHEA:23096
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008903
name: hydroxypyruvate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11952]
synonym: "hydroxypyruvate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.22]
synonym: "hydroxypyruvate ketol-isomerase activity" RELATED [EC:5.3.1.22]
xref: EC:5.3.1.22
xref: KEGG_REACTION:R01394
xref: MetaCyc:RXN0-305
xref: RHEA:11952
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008904
name: hygromycin-B 7''-O-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H+." [EC:2.7.1.119, RHEA:23388]
synonym: "APH(7'') activity" RELATED [EC:2.7.1.119]
synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" RELATED [EC:2.7.1.119]
synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT []
synonym: "hygromycin B kinase activity" BROAD []
synonym: "hygromycin B phosphotransferase activity" BROAD [EC:2.7.1.119]
synonym: "hygromycin-B kinase activity" BROAD []
xref: EC:2.7.1.119
xref: KEGG_REACTION:R03770
xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN
xref: RHEA:23388
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0008905
name: obsolete mannose-phosphate guanylyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
consider: GO:0004475
consider: GO:0008928
consider: GO:0010471

[Term]
id: GO:0008906
name: inosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73]
synonym: "ATP:inosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.73]
synonym: "inosine kinase (phosphorylating)" RELATED [EC:2.7.1.73]
synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73]
xref: MetaCyc:INOSINEKIN-RXN
xref: RHEA:21140
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008907
name: integrase activity
namespace: molecular_function
def: "Catalysis of the integration of one DNA segment into another." [GOC:mah]
subset: goslim_pir
xref: Reactome:R-HSA-164523 "Transesterification to connect viral DNA 3' ends to host DNA 5' ends"
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0008908
name: isochorismatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate." [EC:3.3.2.1, RHEA:11112]
synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" RELATED [EC:3.3.2.1]
synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" RELATED [EC:3.3.2.1]
synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" RELATED [EC:3.3.2.1]
synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" RELATED [EC:3.3.2.1]
synonym: "isochorismate pyruvate-hydrolase activity" RELATED [EC:3.3.2.1]
xref: EC:3.3.2.1
xref: KEGG_REACTION:R03037
xref: MetaCyc:ISOCHORMAT-RXN
xref: RHEA:11112
is_a: GO:0004463 ! leukotriene-A4 hydrolase activity

[Term]
id: GO:0008909
name: isochorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.4.2, RHEA:18985]
synonym: "isochorismate hydroxymutase activity" RELATED [EC:5.4.4.2]
synonym: "isochorismate mutase activity" EXACT []
synonym: "isochorismate synthetase activity" RELATED [EC:5.4.4.2]
xref: EC:5.4.4.2
xref: KEGG_REACTION:R01717
xref: MetaCyc:ISOCHORSYN-RXN
xref: RHEA:18985
is_a: GO:0050486 ! intramolecular hydroxytransferase activity

[Term]
id: GO:0008910
name: kanamycin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H+ + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24256]
synonym: "aminoglycoside 3'-phosphotransferase activity" BROAD [EC:2.7.1.95]
synonym: "APH(3') activity" BROAD [EC:2.7.1.95]
synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" RELATED [EC:2.7.1.95]
synonym: "kanamycin kinase (phosphorylating)" RELATED [EC:2.7.1.95]
synonym: "neomycin phosphotransferase activity" RELATED [EC:2.7.1.95]
synonym: "neomycin-kanamycin phosphotransferase activity" RELATED [EC:2.7.1.95]
xref: EC:2.7.1.95
xref: KEGG_REACTION:R01888
xref: MetaCyc:KANAMYCIN-KINASE-RXN
xref: RHEA:24256
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0008911
name: lactaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [RHEA:14277]
synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.22]
synonym: "L-lactaldehyde:NAD oxidoreductase activity" RELATED [EC:1.2.1.22]
synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" RELATED [EC:1.2.1.22]
xref: EC:1.2.1.22
xref: MetaCyc:LACTALDDEHYDROG-RXN
xref: RHEA:14277
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0008912
name: lactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+." [EC:1.1.1.77]
synonym: "(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.77]
synonym: "lactaldehyde:propanediol oxidoreductase activity" RELATED [EC:1.1.1.77]
synonym: "propanediol oxidoreductase activity" BROAD [EC:1.1.1.77]
synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" RELATED [EC:1.1.1.77]
xref: EC:1.1.1.77
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008913
name: Kdo2-lipid IVA acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]." [EC:2.3.1.241, PMID:18656959]
synonym: "(Kdo)2-lipid IVA lauroyltransferase" RELATED [EC:2.3.1.241]
synonym: "alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA lauroyltransferase" RELATED [EC:2.3.1.241]
synonym: "Kdo2-lipid IVA lauroyltransferase" RELATED [EC:2.3.1.241]
synonym: "lauroyl transferase activity" RELATED []
synonym: "lauroyltransferase activity" RELATED []
xref: EC:2.3.1.241
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0008914
name: leucyl-tRNA--protein transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue." [EC:2.3.2.6]
synonym: "L/F transferase activity" RELATED []
synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" RELATED [EC:2.3.2.6]
synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" RELATED [EC:2.3.2.6]
synonym: "leucyltransferase activity" RELATED [EC:2.3.2.6]
xref: EC:2.3.2.6
xref: MetaCyc:LEUCYLTRANSFERASE-RXN
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008915
name: lipid-A-disaccharide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H+ + UDP." [EC:2.4.1.182, RHEA:22668]
synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" RELATED [EC:2.4.1.182]
xref: EC:2.4.1.182
xref: KEGG_REACTION:R04606
xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN
xref: RHEA:22668
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0008917
name: lipopolysaccharide N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr]
synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.56]
synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.56]
synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.56]
xref: EC:2.4.1.56
xref: MetaCyc:RXN-22502
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008918
name: lipopolysaccharide 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr]
synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" RELATED [EC:2.4.1.44]
synonym: "lipopolysaccharide galactosyltransferase activity" EXACT []
synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW []
synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.44]
synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" RELATED [EC:2.4.1.44]
synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" RELATED [EC:2.4.1.44]
synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.44]
synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" RELATED [EC:2.4.1.44]
synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" RELATED [EC:2.4.1.44]
xref: EC:2.4.1.44
xref: MetaCyc:RXN-22172
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008919
name: lipopolysaccharide glucosyltransferase I activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58]
synonym: "lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58]
synonym: "LPS glucosyltransferase I activity" EXACT []
synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58]
synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58]
synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58]
synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58]
synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58]
xref: EC:2.4.1.58
xref: MetaCyc:RXN0-5126
xref: RHEA:30015
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008920
name: lipopolysaccharide heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+." [GOC:curators]
synonym: "LPS heptosyltransferase activity" EXACT []
is_a: GO:0016757 ! glycosyltransferase activity

[Term]
id: GO:0008921
name: lipopolysaccharide-1,6-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai]
synonym: "LPS-1,6-galactosyltransferase activity" EXACT []
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008922
name: long-chain fatty acid [acyl-carrier-protein] ligase activity
namespace: molecular_function
alt_id: GO:0010300
def: "Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [EC:6.2.1.20]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "acyl-[acyl-carrier-protein] synthetase activity" RELATED [EC:6.2.1.20]
synonym: "acyl-ACP synthetase activity" EXACT []
synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20]
synonym: "acyl-acyl-carrier-protein synthetase activity" RELATED [EC:6.2.1.20]
synonym: "acyl-acyl-carrier-proteinsynthetase activity" RELATED [EC:6.2.1.20]
synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT []
synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" RELATED [EC:6.2.1.20]
synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" RELATED [EC:6.2.1.20]
synonym: "stearoyl-ACP synthetase activity" RELATED [EC:6.2.1.20]
xref: EC:6.2.1.20
xref: KEGG_REACTION:R07325
xref: MetaCyc:ACYLACPSYNTH-RXN
xref: RHEA:45588
is_a: GO:0015645 ! fatty acid ligase activity

[Term]
id: GO:0008923
name: lysine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + H+ = cadaverine + CO2." [RHEA:22352]
synonym: "L-lysine carboxy-lyase activity" RELATED [EC:4.1.1.18]
xref: EC:4.1.1.18
xref: KEGG_REACTION:R00462
xref: MetaCyc:LYSDECARBOX-RXN
xref: RHEA:22352
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008924
name: L-malate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol. Vitamin K (menaquinone) and several other quinones can act as acceptors." [PMID:234747, RHEA:46012]
synonym: "(S)-malate:(quinone) oxidoreductase activity" RELATED [EC:1.1.5.4]
synonym: "(S)-malate:quinone oxidoreductase activity" RELATED [EC:1.1.5.4]
synonym: "FAD-dependent malate dehydrogenase activity" RELATED [EC:1.1.5.4]
synonym: "MQO activity" BROAD [EC:1.1.5.4]
xref: EC:1.1.5.4
xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:46012
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0008925
name: maltose O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79]
synonym: "acetyl-CoA:maltose O-acetyltransferase activity" RELATED [EC:2.3.1.79]
synonym: "maltose transacetylase activity" RELATED [EC:2.3.1.79]
xref: EC:2.3.1.79
xref: MetaCyc:MALTACETYLTRAN-RXN
xref: RHEA:10456
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008926
name: mannitol-1-phosphate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
xref: EC:1.1.1.17
xref: MetaCyc:MANNPDEHYDROG-RXN
xref: RHEA:19661
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008927
name: mannonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.8, RHEA:20097]
synonym: "altronate hydrolase activity" RELATED [EC:4.2.1.8]
synonym: "altronic hydro-lyase activity" RELATED [EC:4.2.1.8]
synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" RELATED [EC:4.2.1.8]
synonym: "D-mannonate hydro-lyase activity" RELATED [EC:4.2.1.8]
synonym: "D-mannonate hydrolyase activity" RELATED [EC:4.2.1.8]
synonym: "mannonate hydrolyase activity" RELATED [EC:4.2.1.8]
synonym: "mannonic hydrolase activity" RELATED [EC:4.2.1.8]
xref: EC:4.2.1.8
xref: KEGG_REACTION:R05606
xref: MetaCyc:MANNONDEHYDRAT-RXN
xref: RHEA:20097
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008928
name: mannose-1-phosphate guanylyltransferase (GDP) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H+ = GDP-alpha-D-mannose + phosphate." [RHEA:12905]
synonym: "GDP mannose phosphorylase activity" RELATED [EC:2.7.7.22]
synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" RELATED []
synonym: "GDP-mannose phosphorylase activity" RELATED [EC:2.7.7.22]
synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22]
synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" RELATED []
synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" RELATED []
synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" RELATED []
synonym: "guanosine diphosphomannose phosphorylase activity" RELATED []
synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" RELATED []
synonym: "mannose 1-phosphate guanylyltransferase activity" RELATED []
xref: EC:2.7.7.22
xref: KEGG_REACTION:R00883
xref: MetaCyc:MANNPGUANYLTRANGDP-RXN
xref: RHEA:12905
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0008929
name: methylglyoxal synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3, RHEA:17937]
synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" RELATED [EC:4.2.3.3]
synonym: "glycerone-phosphate phospho-lyase activity" RELATED [EC:4.2.3.3]
synonym: "methylglyoxal synthetase activity" RELATED [EC:4.2.3.3]
xref: EC:4.2.3.3
xref: KEGG_REACTION:R01016
xref: MetaCyc:METHGLYSYN-RXN
xref: RHEA:17937
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0008930
name: methylthioadenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16]
synonym: "5'-methylthioadenosine nucleosidase activity" RELATED [EC:3.2.2.16]
synonym: "MeSAdo nucleosidase activity" RELATED [EC:3.2.2.16]
synonym: "methylthioadenosine methylthioribohydrolase activity" RELATED [EC:3.2.2.16]
synonym: "MTA nucleosidase activity" RELATED [EC:3.2.2.16]
synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" RELATED [EC:3.2.2.16]
xref: EC:3.2.2.16
xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN
xref: RHEA:13617
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0008931
name: obsolete murein DD-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "murein DD-endopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008932
name: lytic endotransglycosylase activity
namespace: molecular_function
def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199]
synonym: "murein lytic endotransglycosylase E activity" NARROW []
xref: EC:4.2.2.n2
is_a: GO:0008933 ! lytic transglycosylase activity

[Term]
id: GO:0008933
name: lytic transglycosylase activity
namespace: molecular_function
def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424, PMID:22748813]
synonym: "murein transglycosylase B activity" NARROW []
synonym: "peptidoglycan lytic transglycosylase activity" EXACT []
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides
is_a: GO:0061783 ! peptidoglycan muralytic activity

[Term]
id: GO:0008934
name: inositol monophosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [RHEA:27670]
synonym: "inositol 1-phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25]
synonym: "L-myo-inositol-1-phosphate phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "myo-inositol 1-phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD []
synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25]
synonym: "myo-inositol-1-phosphatase activity" RELATED [EC:3.1.3.25]
xref: MetaCyc:RXN0-5408
xref: Reactome:R-HSA-1855154 "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol"
xref: RHEA:27670
is_a: GO:0052834 ! inositol monophosphate phosphatase activity

[Term]
id: GO:0008935
name: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O." [RHEA:26562]
synonym: "DHNA synthetase activity" RELATED [EC:4.1.3.36]
synonym: "dihydroxynaphthoate synthase activity" RELATED []
synonym: "dihydroxynaphthoic acid synthetase activity" RELATED [EC:4.1.3.36]
synonym: "naphthoate synthase activity" RELATED [EC:4.1.3.36]
synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" RELATED [EC:4.1.3.36]
xref: EC:4.1.3.36
xref: KEGG_REACTION:R04150
xref: MetaCyc:NAPHTHOATE-SYN-RXN
xref: RHEA:26562
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008936
name: nicotinamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [RHEA:14545]
synonym: "NAMase activity" RELATED [EC:3.5.1.19]
synonym: "nicotinamide amidase activity" RELATED [EC:3.5.1.19]
synonym: "nicotinamide amidohydrolase activity" RELATED [EC:3.5.1.19]
synonym: "nicotinamide deaminase activity" RELATED [EC:3.5.1.19]
synonym: "nicotine deamidase activity" RELATED [EC:3.5.1.19]
synonym: "YNDase activity" RELATED [EC:3.5.1.19]
xref: EC:3.5.1.19
xref: MetaCyc:NICOTINAMID-RXN
xref: RHEA:14545
is_a: GO:0004040 ! amidase activity

[Term]
id: GO:0008937
name: ferredoxin-NAD(P) reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [GOC:curators]
subset: gocheck_do_not_annotate
synonym: "ferredoxin reductase activity" BROAD []
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0008938
name: nicotinate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine." [EC:2.1.1.7, RHEA:20241]
synonym: "furanocoumarin 8-O-methyltransferase activity" RELATED [EC:2.1.1.7]
synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" RELATED [EC:2.1.1.7]
xref: EC:2.1.1.7
xref: KEGG_REACTION:R01721
xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN
xref: RHEA:20241
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008939
name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate." [EC:2.4.2.21, RHEA:11196]
synonym: "CobT" RELATED [EC:2.4.2.21]
synonym: "N(1)-alpha-phosphoribosyltransferase activity" RELATED [EC:2.4.2.21]
synonym: "N1-alpha-phosphoribosyltransferase activity" RELATED [EC:2.4.2.21]
synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" RELATED [EC:2.4.2.21]
synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" RELATED [EC:2.4.2.21]
synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" RELATED [EC:2.4.2.21]
synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.21]
synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.21]
xref: EC:2.4.2.21
xref: KEGG_REACTION:R04148
xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN
xref: RHEA:11196
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0008940
name: nitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor." [RHEA:21068]
synonym: "nitrate reductase (acceptor)" RELATED []
synonym: "nitrite:(acceptor) oxidoreductase" RELATED []
synonym: "nitrite:acceptor oxidoreductase" RELATED []
synonym: "respiratory nitrate reductase activity" NARROW []
xref: RHEA:21068
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0008941
name: nitric oxide dioxygenase NAD(P)H activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+." [EC:1.14.12.17]
comment: Note that this activity is similar to nitric oxide dioxygenase activity, heme protein ; GO:0141118, but GO:0141118 uses a heme protein as the electron donor.
synonym: "nitric oxide dioxygenase activity" BROAD []
synonym: "NOD activity" RELATED [EC:1.14.12.17]
xref: EC:1.14.12.17
xref: MetaCyc:R621-RXN
xref: Reactome:R-HSA-1222723 "Nitric oxide is oxidized to nitrate"
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0008942
name: nitrite reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: NH4+ + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+." [EC:1.7.1.4, PMID:31961593]
synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" RELATED [EC:1.7.1.4]
synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4]
synonym: "NAD(P)H2:nitrite oxidoreductase activity" RELATED [EC:1.7.1.4]
synonym: "NAD(P)H:nitrite oxidoreductase activity" RELATED [EC:1.7.1.4]
synonym: "NADH-nitrite oxidoreductase activity" RELATED [EC:1.7.1.4]
synonym: "NADPH-nitrite reductase activity" RELATED [EC:1.7.1.4]
synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" RELATED [EC:1.7.1.4]
synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4]
xref: EC:1.7.1.4
xref: KEGG_REACTION:R00787
xref: KEGG_REACTION:R00789
xref: MetaCyc:RXN0-6377
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0008943
name: obsolete glyceraldehyde-3-phosphate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+." [GOC:curators]
comment: This term was made obsolete because it is a grouping term based on similar names.
synonym: "glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
is_obsolete: true
consider: GO:0004365
consider: GO:0008886
consider: GO:0043878
consider: GO:0047100

[Term]
id: GO:0008944
name: obsolete oligopeptidase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "68000-M signalpeptide hydrolase activity" RELATED []
synonym: "oligopeptidase A activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008945
name: obsolete oligopeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "Escherichia coli alkaline proteinase II" RELATED []
synonym: "oligopeptidase B activity" EXACT []
synonym: "protease II activity" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008946
name: oligonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3]
comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP.
xref: EC:3.1.13.3
xref: MetaCyc:3.1.13.3-RXN
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0008947
name: obsolete omptin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "omptin activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008948
name: oxaloacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate." [RHEA:15641]
synonym: "oxalacetic acid decarboxylase activity" EXACT []
synonym: "oxalate beta-decarboxylase activity" RELATED [EC:4.1.1.112]
synonym: "oxaloacetate beta-decarboxylase activity" RELATED [EC:4.1.1.112]
synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT []
synonym: "oxaloacetate carboxy-lyase activity" RELATED [EC:4.1.1.112]
xref: EC:4.1.1.112
xref: KEGG_REACTION:R00217
xref: MetaCyc:OXALODECARB-RXN
xref: Reactome:R-HSA-9012016 "FAHD1 dimer hydrolyses OA to PYR"
xref: Reactome:R-HSA-9861660 "ME1 tetramer decarboxylates OA to PYR"
xref: RHEA:15641
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008949
name: oxalyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + oxalyl-CoA = CO2 + formyl-CoA." [EC:4.1.1.8, RHEA:19333]
synonym: "oxalyl coenzyme A decarboxylase activity" RELATED [EC:4.1.1.8]
synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" RELATED [EC:4.1.1.8]
synonym: "oxalyl-CoA carboxy-lyase activity" RELATED [EC:4.1.1.8]
xref: EC:4.1.1.8
xref: KEGG_REACTION:R01908
xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN
xref: RHEA:19333
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008950
name: obsolete p-aminobenzoate synthetase
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered.
synonym: "p-aminobenzoate synthetase" EXACT []
is_obsolete: true
consider: GO:0008696
consider: GO:0046820

[Term]
id: GO:0008951
name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN]
synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT []
xref: MetaCyc:PALMITOTRANS-RXN
xref: RHEA:44012
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0008953
name: penicillin amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11]
synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" RELATED [EC:3.5.1.11]
synonym: "ampicillin acylase activity" RELATED [EC:3.5.1.11]
synonym: "benzylpenicillin acylase activity" RELATED [EC:3.5.1.11]
synonym: "novozym 217" RELATED [EC:3.5.1.11]
synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT []
synonym: "penicillin acylase activity" RELATED [EC:3.5.1.11]
synonym: "penicillin amidohydrolase activity" RELATED [EC:3.5.1.11]
synonym: "semacylase activity" RELATED [EC:3.5.1.11]
xref: EC:3.5.1.11
xref: MetaCyc:PENICILLIN-AMIDASE-RXN
xref: RHEA:18693
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008954
name: obsolete peptidoglycan synthetase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was not defined, is ambiguous, and has been used to annotate gene products with very different activities.
synonym: "peptidoglycan synthetase activity" EXACT []
is_obsolete: true
consider: GO:0008955
consider: GO:0071972

[Term]
id: GO:0008955
name: peptidoglycan glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+." [RHEA:23708]
synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.99.28]
synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.99.28]
synonym: "peptidoglycan TGase activity" RELATED [EC:2.4.99.28]
synonym: "peptidoglycan transglycosylase activity" RELATED [EC:2.4.99.28]
synonym: "PG-II activity" RELATED [EC:2.4.99.28]
synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" RELATED [EC:2.4.99.28]
xref: EC:2.4.99.28
xref: MetaCyc:RXN-14712
xref: RHEA:23708
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0008956
name: obsolete peptidyl-dipeptidase Dcp activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "peptidyl-dipeptidase Dcp activity" EXACT []
is_obsolete: true
consider: GO:0008235
consider: GO:0008241

[Term]
id: GO:0008957
name: phenylacetaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phenylacetaldehyde + H2O + NAD+ = 2-phenylacetate + 2 H+ + NADH." [RHEA:21392]
synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.39]
xref: EC:1.2.1.39
xref: MetaCyc:PHENDEHYD-RXN
xref: RHEA:21392
xref: UM-BBD_reactionID:r0035
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0008959
name: phosphate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8]
synonym: "acetyl-CoA:phosphate acetyltransferase activity" RELATED [EC:2.3.1.8]
synonym: "phosphoacylase activity" RELATED [EC:2.3.1.8]
synonym: "phosphotransacetylase activity" RELATED [EC:2.3.1.8]
synonym: "PTA" RELATED [EC:2.3.1.8]
xref: EC:2.3.1.8
xref: MetaCyc:PHOSACETYLTRANS-RXN
xref: RHEA:19521
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0008960
name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20]
synonym: "oligosaccharide glycerophosphotransferase activity" RELATED [EC:2.7.8.20]
synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" RELATED [EC:2.7.8.20]
synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20]
synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20]
xref: EC:2.7.8.20
xref: MetaCyc:PGLYCEROLTRANSI-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008961
name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein." [PMID:8051048, RHEA:56712]
xref: EC:2.5.1.145
xref: RHEA:56712
is_a: GO:0016757 ! glycosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008962
name: phosphatidylglycerophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [PMID:4292860]
synonym: "PGP phosphatase activity" RELATED [EC:3.1.3.27]
synonym: "phosphatidylglycerol phosphatase activity" RELATED [EC:3.1.3.27]
synonym: "phosphatidylglycerol phosphate phosphatase activity" RELATED [EC:3.1.3.27]
synonym: "phosphatidylglycerophosphate phosphohydrolase activity" RELATED [EC:3.1.3.27]
xref: EC:3.1.3.27
xref: MetaCyc:PGPPHOSPHA-RXN
xref: Reactome:R-HSA-1483197 "PTPMT1 dephosphorylates PGP to PG"
xref: RHEA:16725
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008963
name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP." [RHEA:21920]
comment: Note that EC classifies all three 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under EC:2.7.8.13.
subset: goslim_chembl
synonym: "MraY transferase activity" NARROW [EC:2.7.8.13]
synonym: "phospho-MurNAc-pentapeptide transferase activity" RELATED [EC:2.7.8.13]
synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" RELATED [EC:2.7.8.13]
synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" RELATED [EC:2.7.8.13]
synonym: "phosphoacetylmuramoylpentapeptide translocase activity" RELATED [EC:2.7.8.13]
synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" RELATED [EC:2.7.8.13]
synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" RELATED [EC:2.7.8.13]
synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" RELATED [EC:2.7.8.13]
synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" RELATED [EC:2.7.8.13]
synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" RELATED [EC:2.7.8.13]
synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" RELATED [EC:2.7.8.13]
synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" RELATED [EC:2.7.8.13]
xref: MetaCyc:RXN-8975
xref: RHEA:21920
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008964
name: phosphoenolpyruvate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-." [EC:4.1.1.31]
synonym: "PEP carboxylase activity" RELATED [EC:4.1.1.31]
synonym: "PEPC" RELATED [EC:4.1.1.31]
synonym: "PEPCase activity" RELATED [EC:4.1.1.31]
synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.31]
synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" RELATED [EC:4.1.1.31]
synonym: "phosphoenolpyruvic carboxylase activity" RELATED [EC:4.1.1.31]
synonym: "phosphopyruvate (phosphate) carboxylase activity" RELATED [EC:4.1.1.31]
xref: EC:4.1.1.31
xref: KEGG_REACTION:R00345
xref: MetaCyc:PEPCARBOX-RXN
xref: RHEA:28370
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0008965
name: phosphoenolpyruvate-protein phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9]
synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9]
synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" RELATED [EC:2.7.3.9]
synonym: "phosphoenolpyruvate--protein phosphatase activity" RELATED [EC:2.7.3.9]
synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" RELATED [EC:2.7.3.9]
synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" RELATED [EC:2.7.3.9]
synonym: "phosphopyruvate--protein factor phosphotransferase activity" RELATED [EC:2.7.3.9]
synonym: "phosphopyruvate--protein phosphotransferase activity" RELATED [EC:2.7.3.9]
synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9]
xref: EC:2.7.3.9
xref: MetaCyc:2.7.3.9-RXN
xref: RHEA:23880
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0008966
name: phosphoglucosamine mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10, RHEA:23424]
synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.10]
synonym: "D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.10]
xref: EC:5.4.2.10
xref: KEGG_REACTION:R02060
xref: MetaCyc:5.4.2.10-RXN
xref: RHEA:23424
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0008967
name: phosphoglycolate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14369]
synonym: "2-phosphoglycolate phosphatase activity" RELATED [EC:3.1.3.18]
synonym: "2-phosphoglycolate phosphohydrolase activity" RELATED [EC:3.1.3.18]
synonym: "P-glycolate phosphatase activity" RELATED [EC:3.1.3.18]
synonym: "phosphoglycolate hydrolase activity" RELATED [EC:3.1.3.18]
synonym: "phosphoglycollate phosphatase activity" RELATED [EC:3.1.3.18]
xref: EC:3.1.3.18
xref: KEGG_REACTION:R01334
xref: MetaCyc:GPH-RXN
xref: RHEA:14369
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008968
name: D-sedoheptulose 7-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969]
synonym: "phosphoheptose isomerase activity" EXACT []
xref: MetaCyc:RXN0-4301
xref: RHEA:27489
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0008970
name: phospholipase A1 activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+." [RHEA:18689]
subset: goslim_chembl
synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT []
xref: EC:3.1.1.32
xref: MetaCyc:PHOSPHOLIPASE-A1-RXN
xref: Reactome:R-HSA-1482827 "PC is hydrolyzed to 2-acyl LPC by PLA2G4C"
xref: Reactome:R-HSA-1482828 "PE is hydrolyzed to 2-acyl LPE by PLA2[4]"
xref: Reactome:R-HSA-1482847 "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)"
xref: Reactome:R-HSA-1482862 "PC is hydrolysed to 2-acyl LPC by PLA2[7]"
xref: Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C"
xref: Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]"
xref: Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]"
xref: Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC"
xref: RHEA:18689
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0008972
name: phosphomethylpyrimidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7]
synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" RELATED [EC:2.7.4.7]
synonym: "hydroxymethylpyrimidine phosphokinase activity" RELATED [EC:2.7.4.7]
xref: EC:2.7.4.7
xref: MetaCyc:PYRIMSYN3-RXN
xref: RHEA:19893
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0008973
name: phosphopentomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. Also converts 2-deoxy-alpha-D-ribose 1-phosphate into 2-deoxy-D-ribose 5-phosphate." [EC:5.4.2.7]
synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" RELATED [EC:5.4.2.7]
synonym: "alpha-D-ribose 1,5-phosphomutase activity" RELATED [EC:5.4.2.7]
synonym: "D-ribose 1,5-phosphomutase activity" RELATED [EC:5.4.2.7]
synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7]
synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7]
synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7]
synonym: "phosphoribomutase activity" RELATED [EC:5.4.2.7]
xref: EC:5.4.2.7
xref: MetaCyc:PPENTOMUT-RXN
xref: Reactome:R-HSA-6787329 "PGM2:Mg2+ isomerises R1P to R5P"
xref: Reactome:R-HSA-8982667 "PGM2:Mg2+ isomerises  dR1P to dR5P"
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0008974
name: phosphoribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+." [EC:2.7.1.19, RHEA:19365]
synonym: "5-phosphoribulose kinase activity" RELATED [EC:2.7.1.19]
synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.19]
synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19]
synonym: "phosphoribulokinase (phosphorylating)" RELATED [EC:2.7.1.19]
synonym: "PKK" RELATED [EC:2.7.1.19]
synonym: "PRK" RELATED [EC:2.7.1.19]
synonym: "PRuK" RELATED [EC:2.7.1.19]
synonym: "ribulose phosphate kinase activity" RELATED [EC:2.7.1.19]
synonym: "ribulose-5-phosphate kinase activity" RELATED [EC:2.7.1.19]
xref: EC:2.7.1.19
xref: KEGG_REACTION:R01523
xref: MetaCyc:PHOSPHORIBULOKINASE-RXN
xref: RHEA:19365
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008975
name: obsolete pitrilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "Escherichia coli metalloproteinase Pi" RELATED []
synonym: "Escherichia coli protease III" RELATED []
synonym: "pitrilysin activity" EXACT []
synonym: "protease III activity" RELATED []
synonym: "protease Pi activity" RELATED []
synonym: "proteinase Pi" RELATED []
synonym: "PTR" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008976
name: polyphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1]
synonym: "ATP-polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.1]
synonym: "ATP:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.1]
synonym: "polyphosphate polymerase activity" EXACT []
synonym: "polyphosphoric acid kinase activity" RELATED [EC:2.7.4.1]
xref: EC:2.7.4.1
xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN
xref: RHEA:19573
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0008977
name: prephenate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADH." [EC:1.3.1.12, RHEA:13869]
synonym: "chorismate mutase--prephenate dehydrogenase activity" RELATED [EC:1.3.1.12]
synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12]
synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.12]
xref: EC:1.3.1.12
xref: KEGG_REACTION:R01728
xref: MetaCyc:PREPHENATEDEHYDROG-RXN
xref: RHEA:13869
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008978
name: obsolete prepilin peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43]
comment: This term was made obsolete because it represents a gene product.
synonym: "prepilin peptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0008979
name: prophage integrase activity
namespace: molecular_function
def: "Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA." [GOC:jl]
synonym: "integrase activity involved in establishment of integrated proviral latency" EXACT []
is_a: GO:0009009 ! site-specific recombinase activity

[Term]
id: GO:0008980
name: propionate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate." [EC:2.7.2.15]
synonym: "ATP:propanoate phosphotransferase activity" EXACT []
synonym: "PduW" RELATED []
synonym: "propanoate kinase activity" EXACT []
synonym: "TdcD" RELATED []
xref: EC:2.7.2.15
xref: RHEA:23148
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008981
name: obsolete protease IV activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "protease IV activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008982
name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
namespace: molecular_function
alt_id: GO:0015455
alt_id: GO:0015456
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "enzyme II of the phosphotransferase system" RELATED []
synonym: "PEP--sugar phosphotransferase enzyme II activity" EXACT []
synonym: "PEP-dependent phosphotransferase enzyme II" RELATED []
synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED []
synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" RELATED []
synonym: "phosphoprotein factor-hexose phosophotransferase activity" RELATED []
synonym: "phosphotransfer-driven group translocator" BROAD []
synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT []
synonym: "PTS permease activity" RELATED []
synonym: "PTS transporter" RELATED []
xref: TC:4.A
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0008983
name: protein-glutamate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80]
synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80]
synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80]
synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80]
synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80]
synonym: "protein carboxyl-methylase activity" RELATED [EC:2.1.1.80]
synonym: "protein carboxyl-O-methyltransferase activity" RELATED [EC:2.1.1.80]
synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80]
synonym: "protein carboxymethylase activity" RELATED [EC:2.1.1.80]
synonym: "protein carboxymethyltransferase activity" RELATED [EC:2.1.1.80]
synonym: "protein glutamate O-methylase activity" EXACT []
synonym: "protein glutamate O-methyltransferase activity" EXACT []
synonym: "protein methylase II" RELATED [EC:2.1.1.80]
synonym: "protein O-methyltransferase activity" RELATED [EC:2.1.1.80]
synonym: "protein(aspartate)methyltransferase activity" RELATED [EC:2.1.1.80]
synonym: "protein(carboxyl)methyltransferase activity" RELATED [EC:2.1.1.80]
synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" RELATED [EC:2.1.1.80]
synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" RELATED [EC:2.1.1.80]
synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" RELATED [EC:2.1.1.80]
xref: EC:2.1.1.80
xref: MetaCyc:CHER-RXN
xref: RESID:AA0072
xref: RHEA:24452
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity

[Term]
id: GO:0008984
name: protein-glutamate methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072]
synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61]
synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61]
synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61]
synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61]
synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" RELATED [EC:3.1.1.61]
synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" RELATED [EC:3.1.1.61]
xref: EC:3.1.1.61
xref: MetaCyc:MCPMETEST-RXN
xref: RESID:AA0072
xref: RHEA:23236
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0008985
name: obsolete pyruvate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2]
comment: This term was made obsolete because the EC activity it represents, EC:1.2.2.2, has been deleted.
synonym: "pyruvate dehydrogenase (cytochrome) activity" EXACT []
synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" RELATED [EC:1.2.2.2]
synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" RELATED [EC:1.2.2.2]
synonym: "pyruvic (cytochrome b1) dehydrogenase activity" RELATED [EC:1.2.2.2]
is_obsolete: true
replaced_by: GO:0052737

[Term]
id: GO:0008986
name: pyruvate, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + pyruvate = AMP + 2 H+ + phosphate + phosphoenolpyruvate." [RHEA:11364]
synonym: "ATP:pyruvate, water phosphotransferase activity" RELATED [EC:2.7.9.2]
synonym: "PEP synthase activity" EXACT []
synonym: "PEP synthetase activity" RELATED [EC:2.7.9.2]
synonym: "phoephoenolpyruvate synthetase activity" RELATED [EC:2.7.9.2]
synonym: "phosphoenolpyruvate synthase activity" RELATED [EC:2.7.9.2]
synonym: "phosphoenolpyruvic synthase activity" RELATED [EC:2.7.9.2]
synonym: "phosphopyruvate synthetase activity" RELATED [EC:2.7.9.2]
synonym: "pyruvate,water dikinase activity" RELATED [EC:2.7.9.2]
synonym: "pyruvate-water dikinase (phosphorylating)" RELATED [EC:2.7.9.2]
synonym: "water pyruvate dikinase activity" EXACT []
xref: EC:2.7.9.2
xref: KEGG_REACTION:R00199
xref: MetaCyc:PEPSYNTH-RXN
xref: RHEA:11364
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0008987
name: quinolinate synthetase A activity
namespace: molecular_function
def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN]
xref: MetaCyc:QUINOLINATE-SYNTHA-RXN
xref: RHEA:25888
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008988
name: rRNA (adenine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine in rRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine." [RHEA:58728]
synonym: "ErmC 23S rRNA methyltransferase" NARROW []
synonym: "gene ksgA methyltransferase" NARROW []
synonym: "ribonucleic acid-adenine (N(6)) methylase activity" RELATED []
synonym: "ribonucleic acid-adenine (N6) methylase activity" RELATED []
synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" RELATED []
xref: RHEA:58728
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0008989
name: rRNA (guanine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [GOC:curators]
synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" RELATED []
xref: KEGG_REACTION:R07233
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0008990
name: rRNA (guanine-N2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [PMID:17389639]
synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" RELATED []
xref: KEGG_REACTION:R07234
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0008991
name: obsolete serine-type signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
synonym: "serine-type signal peptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008992
name: obsolete repressor LexA activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "LexA repressor" RELATED []
synonym: "repressor lexA" RELATED []
synonym: "repressor LexA activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008993
name: rhamnulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5]
synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" RELATED [EC:2.7.1.5]
synonym: "L-rhamnulokinase activity" RELATED [EC:2.7.1.5]
synonym: "L-rhamnulose kinase activity" RELATED [EC:2.7.1.5]
synonym: "rhamnulokinase (phosphorylating)" RELATED [EC:2.7.1.5]
synonym: "rhamnulose kinase activity" RELATED [EC:2.7.1.5]
synonym: "RhuK" RELATED [EC:2.7.1.5]
xref: EC:2.7.1.5
xref: MetaCyc:RHAMNULOKIN-RXN
xref: RHEA:20117
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008994
name: rhamnulose-1-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19]
synonym: "L-rhamnulose 1-phosphate aldolase activity" RELATED [EC:4.1.2.19]
synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" RELATED [EC:4.1.2.19]
synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.19]
synonym: "L-rhamnulose-phosphate aldolase activity" RELATED [EC:4.1.2.19]
synonym: "rhamnulose phosphate aldolase activity" RELATED [EC:4.1.2.19]
xref: EC:4.1.2.19
xref: MetaCyc:RHAMNULPALDOL-RXN
xref: RHEA:19689
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008995
name: ribonuclease E activity
namespace: molecular_function
def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990]
xref: MetaCyc:3.1.26.12-RXN
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0008996
name: ribonuclease G activity
namespace: molecular_function
def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990]
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0008997
name: obsolete ribonuclease R activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193]
comment: This term was obsoleted because it represents the same activity as exoribonuclease II activity ; GO:0008859.
is_obsolete: true
replaced_by: GO:0008859

[Term]
id: GO:0008998
name: ribonucleoside-triphosphate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate." [RHEA:12701]
synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" RELATED [EC:1.17.4.2]
synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" RELATED [EC:1.17.4.2]
synonym: "ribonucleoside-triphosphate reductase activity" EXACT []
synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2]
xref: EC:1.17.4.2
xref: MetaCyc:1.17.4.2-RXN
xref: RHEA:12701
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0008999
name: peptide-alanine-alpha-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein]." [RHEA:50500]
synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" RELATED []
synonym: "ribosomal protein S18 acetyltransferase activity" RELATED []
synonym: "ribosomal-protein-alanine N-acetyltransferase activity" BROAD []
xref: MetaCyc:RXN-17860
xref: RHEA:50500
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity

[Term]
id: GO:0009000
name: selenocysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16]
synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" RELATED [EC:4.4.1.16]
synonym: "selenocysteine beta-lyase activity" RELATED [EC:4.4.1.16]
synonym: "selenocysteine reductase activity" RELATED [EC:4.4.1.16]
xref: EC:4.4.1.16
xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN
xref: Reactome:R-HSA-2408524 "Sec is reduced to H2Se by PXLP-K259-SCLY dimer"
xref: RHEA:11632
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0009001
name: serine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [RHEA:24560]
synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" RELATED [EC:2.3.1.30]
synonym: "L-serine acetyltransferase activity" RELATED [EC:2.3.1.30]
synonym: "SATase activity" RELATED [EC:2.3.1.30]
synonym: "serine acetyltransferase activity" RELATED [EC:2.3.1.30]
synonym: "serine transacetylase activity" RELATED [EC:2.3.1.30]
xref: EC:2.3.1.30
xref: KEGG_REACTION:R00586
xref: MetaCyc:SERINE-O-ACETTRAN-RXN
xref: RHEA:24560
is_a: GO:0016412 ! serine O-acyltransferase activity
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0009002
name: serine-type D-Ala-D-Ala carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4]
synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4]
synonym: "D-alanyl carboxypeptidase activity" RELATED [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine carboxypeptidase activity" RELATED [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-carboxypeptidase activity" RELATED [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-cleaving peptidase activity" RELATED [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" RELATED [EC:3.4.16.4]
synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4]
synonym: "DD-peptidase activity" RELATED [EC:3.4.16.4]
synonym: "DD-transpeptidase activity" RELATED [EC:3.4.16.4]
xref: EC:3.4.16.4
xref: MetaCyc:3.4.16.4-RXN
is_a: GO:0004185 ! serine-type carboxypeptidase activity

[Term]
id: GO:0009003
name: obsolete signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
synonym: "signal peptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008233

[Term]
id: GO:0009004
name: obsolete signal peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "bacterial leader peptidase 1" RELATED []
synonym: "bacterial leader peptidase I activity" NARROW []
synonym: "Escherichia coli leader peptidase" NARROW []
synonym: "eukaryotic signal peptidase" NARROW []
synonym: "eukaryotic signal proteinase" NARROW []
synonym: "HOSP" RELATED []
synonym: "leader peptidase activity" RELATED []
synonym: "leader peptidase I" RELATED []
synonym: "leader peptide hydrolase activity" RELATED []
synonym: "leader proteinase activity" RELATED []
synonym: "phage-procoat-leader peptidase activity" NARROW []
synonym: "pilin leader peptidase" NARROW []
synonym: "prokaryotic leader peptidase" NARROW []
synonym: "prokaryotic signal peptidase" NARROW []
synonym: "prokaryotic signal proteinase" NARROW []
synonym: "propeptidase activity" RELATED []
synonym: "PuIO prepilin peptidase" NARROW []
synonym: "signal peptidase I activity" EXACT []
synonym: "signal peptide hydrolase activity" RELATED []
synonym: "signal proteinase activity" RELATED []
synonym: "signalase activity" RELATED []
synonym: "SPase I activity" RELATED []
synonym: "SPC" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0009005
name: obsolete signal peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36]
comment: This term was made obsolete because it represents a gene product.
synonym: "leader peptidase II" RELATED [EC:3.4.23.36]
synonym: "lipoprotein signal peptidase activity" RELATED [EC:3.4.23.36]
synonym: "premurein leader proteinase activity" RELATED [EC:3.4.23.36]
synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36]
synonym: "prolipoprotein signal peptidase activity" RELATED [EC:3.4.23.36]
synonym: "prolipoprotein-signal peptidase activity" RELATED [EC:3.4.23.36]
synonym: "signal peptidase II activity" EXACT []
synonym: "SPase II activity" RELATED [EC:3.4.23.36]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0009006
name: obsolete siroheme synthase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents three different molecular functions.
synonym: "sirohaem synthase activity" EXACT []
synonym: "siroheme synthase activity" EXACT []
is_obsolete: true
consider: GO:0004851
consider: GO:0019354
consider: GO:0043115
consider: GO:0051266

[Term]
id: GO:0009007
name: site-specific DNA-methyltransferase (adenine-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]
synonym: "DNA adenine methylase" BROAD []
synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72]
synonym: "modification methylase activity" RELATED [EC:2.1.1.72]
synonym: "N-6 adenine-specific DNA methylase activity" RELATED [EC:2.1.1.72]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72]
xref: EC:2.1.1.72
xref: MetaCyc:2.1.1.72-RXN
xref: RHEA:15197
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity

[Term]
id: GO:0009008
name: DNA-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732, PMID:7862522]
synonym: "deoxyribonucleate methylase activity" EXACT []
synonym: "deoxyribonucleate methyltransferase activity" EXACT []
synonym: "deoxyribonucleic acid methylase activity" EXACT []
synonym: "deoxyribonucleic acid methyltransferase activity" EXACT []
synonym: "deoxyribonucleic acid modification methylase activity" RELATED []
synonym: "DNA methylase" BROAD []
synonym: "DNA methyltransferase activity" EXACT []
synonym: "DNA transmethylase activity" EXACT []
synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37]
xref: Reactome:R-HSA-5227490 "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes"
is_a: GO:0008168 ! methyltransferase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0009009
name: site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences." [GOC:elh, PMID:6286142]
comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds.
subset: goslim_pir
synonym: "RecA-family recombinase activity" EXACT []
is_a: GO:0008907 ! integrase activity

[Term]
id: GO:0009010
name: sorbitol-6-phosphate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140]
synonym: "D-glucitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140]
synonym: "D-sorbitol 6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140]
synonym: "D-sorbitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140]
synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.140]
synonym: "glucitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140]
synonym: "ketosephosphate reductase activity" RELATED [EC:1.1.1.140]
synonym: "sorbitol-6-P-dehydrogenase activity" RELATED [EC:1.1.1.140]
xref: EC:1.1.1.140
xref: MetaCyc:SORB6PDEHYDROG-RXN
xref: RHEA:19837
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009011
name: alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H+." [RHEA:18189]
synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT []
synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT []
synonym: "ADP-glucose starch synthase activity" RELATED [EC:2.4.1.21]
synonym: "ADP-glucose transglucosylase activity" EXACT []
synonym: "ADP-glucose--starch glucosyltransferase activity" RELATED [EC:2.4.1.21]
synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT []
synonym: "ADPG starch synthetase activity" EXACT []
synonym: "ADPG-starch glucosyltransferase activity" EXACT []
synonym: "ADPglucose-starch glucosyltransferase activity" EXACT []
synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT []
synonym: "glycogen synthase activity" RELATED [EC:2.4.1.21]
synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21]
synonym: "starch synthase activity" EXACT []
synonym: "starch synthetase activity" EXACT []
xref: EC:2.4.1.21
xref: MetaCyc:GLYCOGENSYN-RXN
xref: RHEA:18189
is_a: GO:0033840 ! alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity

[Term]
id: GO:0009012
name: aminoglycoside 3''-adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H+." [EC:2.7.7.47, RHEA:20245]
synonym: "AAD (3'')" RELATED [EC:2.7.7.47]
synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW []
synonym: "streptomycin 3''-adenylyltransferase activity" NARROW []
xref: EC:2.7.7.47
xref: KEGG_REACTION:R02226
xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN
xref: RHEA:20245
is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity

[Term]
id: GO:0009013
name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16]
synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" RELATED [EC:1.2.1.16]
synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.16]
xref: EC:1.2.1.16
xref: UM-BBD_reactionID:r0371
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009014
name: succinyl-diaminopimelate desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate." [EC:3.5.1.18, RHEA:22608]
synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" RELATED [EC:3.5.1.18]
synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" RELATED [EC:3.5.1.18]
xref: EC:3.5.1.18
xref: KEGG_REACTION:R02734
xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN
xref: RHEA:22608
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009015
name: N-succinylarginine dihydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4." [EC:3.5.3.23, RHEA:19533]
synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" RELATED [EC:3.5.3.23]
synonym: "arginine succinylhydrolase activity" EXACT []
synonym: "AruB" RELATED []
synonym: "AstB" RELATED []
synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT []
synonym: "N2-succinylarginine dihydrolase activity" EXACT []
synonym: "SADH" RELATED []
synonym: "succinylarginine dihydrolase activity" EXACT []
xref: EC:3.5.3.23
xref: KEGG_REACTION:R04189
xref: MetaCyc:SUCCARGDIHYDRO-RXN
xref: RHEA:19533
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0009016
name: succinyldiaminopimelate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate." [EC:2.6.1.17, RHEA:11960]
synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.17]
synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" RELATED [EC:2.6.1.17]
synonym: "succinyldiaminopimelate aminotransferase activity" EXACT []
synonym: "succinyldiaminopimelate transferase activity" RELATED [EC:2.6.1.17]
xref: EC:2.6.1.17
xref: KEGG_REACTION:R04475
xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN
xref: RHEA:11960
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0009017
name: succinylglutamate desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate." [EC:3.5.1.96, RHEA:15169]
synonym: "AstE" RELATED []
synonym: "N-succinyl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.96]
synonym: "N2-succinylglutamate desuccinylase activity" EXACT []
synonym: "SGDS" RELATED []
xref: EC:3.5.1.96
xref: KEGG_REACTION:R00411
xref: MetaCyc:SUCCGLUDESUCC-RXN
xref: RHEA:15169
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009018
name: sucrose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [RHEA:24048]
synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7]
synonym: "sucrose glucosyltransferase activity" RELATED [EC:2.4.1.7]
synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.7]
xref: EC:2.4.1.7
xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN
xref: RHEA:24048
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0009019
name: obsolete tRNA (guanine-N1-)-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [GOC:curators, PMID:782564]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" RELATED []
synonym: "transfer ribonucleate guanine 1-methyltransferase activity" RELATED []
synonym: "tRNA guanine 1-methyltransferase activity" RELATED []
is_obsolete: true
consider: GO:0052905
consider: GO:0052906

[Term]
id: GO:0009020
name: obsolete tRNA (guanosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34, RHEA:20077]
comment: This term was obsoleted because the label and definition did not match, and annotations were inconsistent.
is_obsolete: true
consider: GO:0106340
consider: GO:0141100

[Term]
id: GO:0009022
name: tRNA nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [PMID:2455297, RHEA:10628]
comment: Note that, although EC names the enzme tRNA nucleotidyltransferase, the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis It should not be confused with CCA tRNA nucleotidyltransferase..
synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56]
synonym: "ribonuclease PH activity" RELATED [EC:2.7.7.56]
synonym: "RNase PH activity" RELATED [EC:2.7.7.56]
xref: EC:2.7.7.56
xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN
xref: RHEA:10628
is_a: GO:0016779 ! nucleotidyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0009023
name: obsolete tRNA sulfurtransferase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators]
synonym: "tRNA sulfurtransferase" EXACT []
synonym: "tRNA sulphurtransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0034227
consider: GO:0016783

[Term]
id: GO:0009024
name: tagatose-6-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144]
synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.144]
synonym: "phosphotagatokinase activity" RELATED [EC:2.7.1.144]
xref: EC:2.7.1.144
xref: MetaCyc:TAGAKIN-RXN
xref: RHEA:12420
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009025
name: tagatose-bisphosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate." [EC:4.1.2.40, RHEA:22948]
synonym: "AgaY" RELATED []
synonym: "AgaZ" RELATED []
synonym: "D-tagatose-1,6-bisphosphate aldolase activity" RELATED [EC:4.1.2.40]
synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.40]
synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT []
synonym: "KbaY" RELATED []
synonym: "tagatose 1,6-diphosphate aldolase activity" RELATED [EC:4.1.2.40]
synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT []
xref: EC:4.1.2.40
xref: KEGG_REACTION:R01069
xref: MetaCyc:TAGAALDOL-RXN
xref: RHEA:22948
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0009026
name: tagaturonate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH." [EC:1.1.1.58, RHEA:17813]
synonym: "altronate dehydrogenase activity" RELATED [EC:1.1.1.58]
synonym: "altronate oxidoreductase activity" RELATED [EC:1.1.1.58]
synonym: "altronic oxidoreductase activity" RELATED [EC:1.1.1.58]
synonym: "D-altronate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.58]
synonym: "D-tagaturonate reductase activity" RELATED [EC:1.1.1.58]
synonym: "tagaturonate dehydrogenase activity" RELATED [EC:1.1.1.58]
synonym: "TagUAR" RELATED [EC:1.1.1.58]
xref: EC:1.1.1.58
xref: KEGG_REACTION:R02555
xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN
xref: RHEA:17813
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009027
name: tartrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93]
synonym: "mesotartrate dehydrogenase activity" RELATED [EC:1.1.1.93]
synonym: "tartrate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.93]
xref: EC:1.1.1.93
xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN
xref: RHEA:15209
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009028
name: tartronate-semialdehyde synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2." [EC:4.1.1.47, RHEA:10136]
synonym: "glyoxalate carboligase activity" RELATED [EC:4.1.1.47]
synonym: "glyoxylate carbo-ligase activity" RELATED [EC:4.1.1.47]
synonym: "glyoxylate carboligase activity" RELATED [EC:4.1.1.47]
synonym: "glyoxylate carboxy-lyase (dimerizing)" RELATED [EC:4.1.1.47]
synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" RELATED [EC:4.1.1.47]
synonym: "glyoxylic carbo-ligase activity" RELATED [EC:4.1.1.47]
synonym: "hydroxymalonic semialdehyde carboxylase activity" RELATED [EC:4.1.1.47]
synonym: "tartronate semialdehyde carboxylase activity" RELATED [EC:4.1.1.47]
synonym: "tartronic semialdehyde carboxylase activity" RELATED [EC:4.1.1.47]
xref: EC:4.1.1.47
xref: KEGG_REACTION:R00013
xref: MetaCyc:GLYOCARBOLIG-RXN
xref: RHEA:10136
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0009029
name: tetraacyldisaccharide 4'-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H+ + lipid IV(a)." [EC:2.7.1.130, RHEA:20700]
synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" RELATED [EC:2.7.1.130]
synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130]
xref: EC:2.7.1.130
xref: KEGG_REACTION:R04657
xref: MetaCyc:TETRAACYLDISACC4KIN-RXN
xref: RHEA:20700
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009030
name: thiamine-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate." [EC:2.7.4.16, RHEA:15913]
synonym: "ATP:thiamine-phosphate phosphotransferase activity" RELATED [EC:2.7.4.16]
synonym: "thiamin monophosphatase activity" RELATED [EC:2.7.4.16]
synonym: "thiamin monophosphokinase activity" RELATED [EC:2.7.4.16]
synonym: "thiamin phosphate kinase activity" EXACT []
synonym: "thiamin-monophosphate kinase activity" RELATED [EC:2.7.4.16]
synonym: "thiamin-phosphate kinase activity" EXACT []
synonym: "thiamine-monophosphate kinase activity" RELATED [EC:2.7.4.16]
xref: EC:2.7.4.16
xref: KEGG_REACTION:R00617
xref: MetaCyc:THI-P-KIN-RXN
xref: RHEA:15913
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0009032
name: thymidine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [RHEA:16037]
synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4]
synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" RELATED []
synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" RELATED []
synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" RELATED []
xref: EC:2.4.2.4
xref: MetaCyc:THYM-PHOSPH-RXN
xref: RHEA:16037
is_a: GO:0016154 ! pyrimidine-nucleoside phosphorylase activity

[Term]
id: GO:0009033
name: obsolete trimethylamine-N-oxide reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this activity exists. The electron donor is cytochrome c.
synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT []
synonym: "trimethylamine N-oxide reductase" EXACT []
synonym: "trimethylamine oxidase activity" EXACT []
synonym: "trimethylamine oxide reductase" EXACT []
is_obsolete: true
consider: GO:0050626

[Term]
id: GO:0009034
name: tryptophanase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + H2O = indole + NH4 + pyruvate." [RHEA:19553]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "L-tryptophan indole-lyase (deaminating) activity" RELATED [EC:4.1.99.1]
synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" RELATED [EC:4.1.99.1]
synonym: "L-tryptophan indole-lyase activity" RELATED [EC:4.1.99.1]
synonym: "L-tryptophanase activity" RELATED [EC:4.1.99.1]
synonym: "TNase activity" RELATED [EC:4.1.99.1]
synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1]
synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1]
xref: EC:4.1.99.1
xref: KEGG_REACTION:R00673
xref: MetaCyc:TRYPTOPHAN-RXN
xref: RHEA:19553
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0009035
name: type I site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [PMID:15300241, PMID:15788748]
synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" RELATED [EC:3.1.21.3]
synonym: "ATP-dependent DNase activity" RELATED [EC:3.1.21.3]
synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" RELATED [EC:3.1.21.3]
synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" RELATED [EC:3.1.21.3]
synonym: "type I restriction enzyme activity" EXACT []
xref: EC:3.1.21.3
xref: MetaCyc:3.1.21.3-RXN
is_a: GO:0015616 ! DNA translocase activity
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0009036
name: type II site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995]
synonym: "type II restriction enzyme activity" EXACT []
xref: EC:3.1.21.4
xref: MetaCyc:3.1.21.4-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0009037
name: tyrosine-based site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626]
synonym: "site-specific tyrosine recombinase activity" EXACT []
synonym: "tyrosine recombinase" BROAD []
is_a: GO:0009009 ! site-specific recombinase activity

[Term]
id: GO:0009038
name: undecaprenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [GOC:curators]
synonym: "ATP:undecaprenol phosphotransferase activity" RELATED [EC:2.7.1.66]
synonym: "C55-isoprenoid alcohol kinase activity" RELATED [EC:2.7.1.66]
synonym: "C55-isoprenoid alcohol phosphokinase activity" RELATED [EC:2.7.1.66]
synonym: "C55-isoprenyl alcohol phosphokinase activity" RELATED [EC:2.7.1.66]
synonym: "isoprenoid alcohol kinase (phosphorylating)" BROAD [EC:2.7.1.66]
synonym: "isoprenoid alcohol kinase activity" BROAD [EC:2.7.1.66]
synonym: "isoprenoid alcohol phosphokinase activity" BROAD [EC:2.7.1.66]
synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66]
synonym: "polyisoprenol kinase activity" BROAD [EC:2.7.1.66]
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009039
name: urease activity
namespace: molecular_function
def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5, RHEA:20557]
synonym: "urea amidohydrolase activity" RELATED [EC:3.5.1.5]
xref: EC:3.5.1.5
xref: MetaCyc:UREASE-RXN
xref: RHEA:20557
xref: UM-BBD_reactionID:r0120
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009040
name: ureidoglycolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+." [EC:1.1.1.154, PMID:23284870]
synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.154]
xref: EC:1.1.1.154
xref: MetaCyc:R165-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009041
name: UMP/dUMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]
is_a: GO:0050145 ! nucleoside monophosphate kinase activity

[Term]
id: GO:0009042
name: valine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66, RHEA:22912]
synonym: "alanine--valine transaminase activity" RELATED [EC:2.6.1.66]
synonym: "alanine-oxoisovalerate aminotransferase activity" RELATED [EC:2.6.1.66]
synonym: "L-valine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.66]
synonym: "transaminase C activity" NARROW [EC:2.6.1.66]
synonym: "valine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.66]
synonym: "valine-pyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.66
xref: KEGG_REACTION:R01215
xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN
xref: RHEA:22912
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0009044
name: xylan 1,4-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37]
synonym: "1,4-beta-D-xylan xylohydrolase activity" RELATED [EC:3.2.1.37]
synonym: "beta-D-xylopyranosidase activity" RELATED [EC:3.2.1.37]
synonym: "beta-xylosidase activity" RELATED [EC:3.2.1.37]
synonym: "exo-1,4-beta-D-xylosidase activity" RELATED [EC:3.2.1.37]
synonym: "exo-1,4-beta-xylosidase activity" RELATED [EC:3.2.1.37]
synonym: "exo-1,4-xylosidase activity" RELATED [EC:3.2.1.37]
synonym: "xylobiase activity" RELATED [EC:3.2.1.37]
xref: EC:3.2.1.37
xref: MetaCyc:3.2.1.37-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0009045
name: xylose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-xylose = alpha-D-xylulofuranose." [RHEA:22816]
synonym: "D-xylose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.5]
synonym: "D-xylose isomerase activity" RELATED [EC:5.3.1.5]
synonym: "D-xylose ketoisomerase activity" RELATED [EC:5.3.1.5]
synonym: "D-xylose ketol-isomerase activity" RELATED [EC:5.3.1.5]
xref: EC:5.3.1.5
xref: MetaCyc:XYLISOM-RXN
xref: RHEA:22816
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0009046
name: zinc D-Ala-D-Ala carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14]
synonym: "D-alanyl-D-alanine hydrolase activity" RELATED [EC:3.4.17.14]
synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" RELATED [EC:3.4.17.14]
synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14]
synonym: "DD-carboxypeptidase-transpeptidase activity" RELATED [EC:3.4.17.14]
synonym: "G enzyme" RELATED [EC:3.4.17.14]
synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14]
synonym: "Zn2+ G peptidase activity" RELATED [EC:3.4.17.14]
xref: EC:3.4.17.14
xref: MetaCyc:3.4.17.14-RXN
is_a: GO:0004181 ! metallocarboxypeptidase activity

[Term]
id: GO:0009047
name: dosage compensation by hyperactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mr, PMID:11498577, PMID:1568251]
xref: Wikipedia:XY_sex-determination_system
is_a: GO:0007549 ! sex-chromosome dosage compensation

[Term]
id: GO:0009048
name: dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, GOC:mr, GOC:pr, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system]
synonym: "Barr body formation" RELATED []
synonym: "chromosome inactivation" BROAD []
synonym: "X chromosome inactivation" EXACT []
xref: Wikipedia:X-inactivation
is_a: GO:0007549 ! sex-chromosome dosage compensation
is_a: GO:0031507 ! heterochromatin formation

[Term]
id: GO:0009049
name: obsolete aspartic-type signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
synonym: "aspartic-type signal peptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0009050
name: glycopeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, a compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732]
synonym: "glycopeptide breakdown" EXACT []
synonym: "glycopeptide catabolism" EXACT []
synonym: "glycopeptide degradation" EXACT []
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009051
name: pentose-phosphate shunt, oxidative branch
namespace: biological_process
def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY]
synonym: "oxidative branch, pentose pathway" EXACT []
synonym: "oxidative pentose phosphate pathway" EXACT []
synonym: "pentose phosphate pathway, oxidative branch" EXACT []
synonym: "pentose phosphate shunt, oxidative branch" EXACT []
synonym: "pentose-phosphate pathway, oxidative branch" EXACT []
is_a: GO:0006740 ! NADPH regeneration
is_a: GO:1901135 ! carbohydrate derivative metabolic process
relationship: part_of GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0009052
name: pentose-phosphate shunt, non-oxidative branch
namespace: biological_process
def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]
synonym: "pentose phosphate pathway, non-oxidative branch" EXACT []
synonym: "pentose phosphate shunt, non-oxidative branch" EXACT []
synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT []
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
relationship: part_of GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0009055
name: electron transfer activity
namespace: molecular_function
alt_id: GO:0009053
alt_id: GO:0009054
def: "A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "electron acceptor activity" NARROW []
synonym: "electron carrier" RELATED []
synonym: "electron donor activity" NARROW []
synonym: "electron transporter activity" RELATED []
xref: Reactome:R-HSA-169260 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF"
xref: Reactome:R-HSA-2564826 "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0009056
name: catabolic process
namespace: biological_process
alt_id: GO:0044243
alt_id: GO:0044712
def: "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "breakdown of chemical" EXACT []
synonym: "breakdown of molecule" EXACT []
synonym: "breakdown of substance" EXACT []
synonym: "catabolism" EXACT []
synonym: "degradation" EXACT []
xref: Wikipedia:Catabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009057
name: macromolecule catabolic process
namespace: biological_process
alt_id: GO:0043285
alt_id: GO:0044266
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: goslim_pir
synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule catabolic process" RELATED []
synonym: "cellular macromolecule catabolism" RELATED []
synonym: "cellular macromolecule degradation" RELATED []
synonym: "macromolecule breakdown" EXACT []
synonym: "macromolecule catabolism" EXACT []
synonym: "macromolecule degradation" EXACT []
synonym: "multicellular organismal macromolecule catabolic process" NARROW []
is_a: GO:0009056 ! catabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0009058
name: biosynthetic process
namespace: biological_process
alt_id: GO:0044274
alt_id: GO:0044711
def: "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "anabolism" EXACT []
synonym: "biosynthesis" EXACT []
synonym: "formation" BROAD []
synonym: "multicellular organismal biosynthetic process" NARROW []
synonym: "single-organism biosynthetic process" RELATED []
synonym: "synthesis" EXACT []
xref: Wikipedia:Anabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0043284
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule anabolism" EXACT []
synonym: "macromolecule biosynthesis" EXACT []
synonym: "macromolecule formation" EXACT []
synonym: "macromolecule synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0009060
name: aerobic respiration
namespace: biological_process
def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]
xref: MetaCyc:PWY-3781
xref: Wikipedia:Cellular_respiration#Aerobic_respiration
is_a: GO:0045333 ! cellular respiration

[Term]
id: GO:0009061
name: anaerobic respiration
namespace: biological_process
def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]
xref: MetaCyc:ANAEROBIC-RESPIRATION
xref: Wikipedia:Anaerobic_respiration
xref: Wikipedia:Cellular_respiration#Anaerobic_respiration
is_a: GO:0045333 ! cellular respiration

[Term]
id: GO:0009062
name: fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]
synonym: "fatty acid breakdown" EXACT []
synonym: "fatty acid catabolism" EXACT []
synonym: "fatty acid degradation" EXACT []
xref: Wikipedia:Fatty_acid_degradation
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0009063
name: amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]
synonym: "amino acid breakdown" EXACT []
synonym: "amino acid catabolism" EXACT []
synonym: "amino acid degradation" EXACT []
synonym: "cellular amino acid catabolic process" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0009064
name: glutamine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
synonym: "glutamine family amino acid metabolism" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0009065
name: glutamine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
synonym: "glutamine family amino acid breakdown" EXACT []
synonym: "glutamine family amino acid catabolism" EXACT []
synonym: "glutamine family amino acid degradation" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process

[Term]
id: GO:0009066
name: aspartate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
synonym: "aspartate family amino acid metabolism" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0009067
name: aspartate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
synonym: "aspartate family amino acid anabolism" EXACT []
synonym: "aspartate family amino acid biosynthesis" EXACT []
synonym: "aspartate family amino acid formation" EXACT []
synonym: "aspartate family amino acid synthesis" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process

[Term]
id: GO:0009068
name: aspartate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
synonym: "aspartate family amino acid breakdown" EXACT []
synonym: "aspartate family amino acid catabolism" EXACT []
synonym: "aspartate family amino acid degradation" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process

[Term]
id: GO:0009069
name: serine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
synonym: "serine family amino acid metabolism" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0009070
name: serine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
synonym: "serine family amino acid anabolism" EXACT []
synonym: "serine family amino acid biosynthesis" EXACT []
synonym: "serine family amino acid formation" EXACT []
synonym: "serine family amino acid synthesis" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process

[Term]
id: GO:0009071
name: serine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
synonym: "serine family amino acid breakdown" EXACT []
synonym: "serine family amino acid catabolism" EXACT []
synonym: "serine family amino acid degradation" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process

[Term]
id: GO:0009072
name: aromatic amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
synonym: "aromatic amino acid family metabolic process" EXACT []
synonym: "aromatic amino acid family metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0009073
name: aromatic amino acid family biosynthetic process
namespace: biological_process
alt_id: GO:0016089
def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
synonym: "aromatic amino acid family anabolism" EXACT []
synonym: "aromatic amino acid family biosynthesis" EXACT []
synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED []
synonym: "aromatic amino acid family formation" EXACT []
synonym: "aromatic amino acid family synthesis" EXACT []
xref: MetaCyc:COMPLETE-ARO-PWY
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009074
name: aromatic amino acid family catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
synonym: "aromatic amino acid family breakdown" EXACT []
synonym: "aromatic amino acid family catabolism" EXACT []
synonym: "aromatic amino acid family degradation" EXACT []
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0009075
name: obsolete histidine family amino acid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family.
synonym: "histidine family amino acid metabolic process" EXACT []
synonym: "histidine family amino acid metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006547

[Term]
id: GO:0009076
name: obsolete histidine family amino acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family.
synonym: "histidine family amino acid anabolism" EXACT []
synonym: "histidine family amino acid biosynthesis" EXACT []
synonym: "histidine family amino acid biosynthetic process" EXACT []
synonym: "histidine family amino acid formation" EXACT []
synonym: "histidine family amino acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0000105

[Term]
id: GO:0009077
name: obsolete histidine family amino acid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family.
synonym: "histidine family amino acid breakdown" EXACT []
synonym: "histidine family amino acid catabolic process" EXACT []
synonym: "histidine family amino acid catabolism" EXACT []
synonym: "histidine family amino acid degradation" EXACT []
is_obsolete: true
replaced_by: GO:0006548

[Term]
id: GO:0009078
name: pyruvate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
synonym: "pyruvate family amino acid metabolism" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0009079
name: pyruvate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
synonym: "pyruvate family amino acid anabolism" EXACT []
synonym: "pyruvate family amino acid biosynthesis" EXACT []
synonym: "pyruvate family amino acid formation" EXACT []
synonym: "pyruvate family amino acid synthesis" EXACT []
is_a: GO:0009078 ! pyruvate family amino acid metabolic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process

[Term]
id: GO:0009080
name: pyruvate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
synonym: "pyruvate family amino acid breakdown" EXACT []
synonym: "pyruvate family amino acid catabolism" EXACT []
synonym: "pyruvate family amino acid degradation" EXACT []
is_a: GO:0009078 ! pyruvate family amino acid metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process

[Term]
id: GO:0009081
name: branched-chain amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]
synonym: "branched chain family amino acid metabolism" EXACT [GOC:ai]
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0009082
name: branched-chain amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]
synonym: "branched chain family amino acid anabolism" EXACT []
synonym: "branched chain family amino acid biosynthesis" EXACT []
synonym: "branched chain family amino acid biosynthetic process" EXACT [GOC:ai]
synonym: "branched chain family amino acid formation" EXACT []
synonym: "branched chain family amino acid synthesis" EXACT []
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009083
name: branched-chain amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]
synonym: "branched chain family amino acid breakdown" EXACT []
synonym: "branched chain family amino acid catabolic process" EXACT [GOC:ai]
synonym: "branched chain family amino acid catabolism" EXACT []
synonym: "branched chain family amino acid degradation" EXACT []
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0009084
name: glutamine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
synonym: "glutamine family amino acid anabolism" EXACT []
synonym: "glutamine family amino acid biosynthesis" EXACT []
synonym: "glutamine family amino acid formation" EXACT []
synonym: "glutamine family amino acid synthesis" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process

[Term]
id: GO:0009085
name: lysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
synonym: "lysine anabolism" EXACT []
synonym: "lysine biosynthesis" EXACT []
synonym: "lysine formation" EXACT []
synonym: "lysine synthesis" EXACT []
xref: MetaCyc:LYSINE-SYN
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009086
name: methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "methionine anabolism" EXACT []
synonym: "methionine biosynthesis" EXACT []
synonym: "methionine formation" EXACT []
synonym: "methionine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0006555 ! methionine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009087
name: methionine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "methionine breakdown" EXACT []
synonym: "methionine catabolism" EXACT []
synonym: "methionine degradation" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0006555 ! methionine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0009088
name: threonine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
synonym: "threonine anabolism" EXACT []
synonym: "threonine biosynthesis" EXACT []
synonym: "threonine formation" EXACT []
synonym: "threonine synthesis" EXACT []
is_a: GO:0006566 ! threonine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009089
name: lysine biosynthetic process via diaminopimelate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]
synonym: "diaminopimelate pathway" EXACT []
synonym: "diaminopimelic acid pathway" EXACT []
synonym: "lysine anabolism via diaminopimelate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT []
synonym: "lysine formation via diaminopimelate" EXACT []
synonym: "lysine synthesis via diaminopimelate" EXACT []
is_a: GO:0009085 ! lysine biosynthetic process
is_a: GO:0046451 ! diaminopimelate metabolic process

[Term]
id: GO:0009090
name: homoserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732]
synonym: "homoserine anabolism" EXACT []
synonym: "homoserine biosynthesis" EXACT []
synonym: "homoserine formation" EXACT []
synonym: "homoserine synthesis" EXACT []
xref: MetaCyc:HOMOSERSYN-PWY
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0009092 ! homoserine metabolic process

[Term]
id: GO:0009091
name: homoserine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732]
synonym: "homoserine breakdown" EXACT []
synonym: "homoserine catabolism" EXACT []
synonym: "homoserine degradation" EXACT []
xref: MetaCyc:HOMOCYSDEGR-PWY
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0009092 ! homoserine metabolic process

[Term]
id: GO:0009092
name: homoserine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732]
synonym: "homoserine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0009093
name: cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
synonym: "cysteine breakdown" EXACT []
synonym: "cysteine catabolism" EXACT []
synonym: "cysteine degradation" EXACT []
xref: Wikipedia:Cysteine
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0009094
name: L-phenylalanine biosynthetic process
namespace: biological_process
alt_id: GO:0019274
alt_id: GO:0019275
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [GOC:jsg, GOC:mah]
synonym: "L-phenylalanine anabolism" EXACT []
synonym: "L-phenylalanine biosynthesis" EXACT []
synonym: "L-phenylalanine formation" EXACT []
synonym: "L-phenylalanine synthesis" EXACT []
synonym: "phenylalanine biosynthesis" BROAD []
synonym: "phenylalanine biosynthetic process" BROAD []
synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED []
synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED []
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway
is_a: GO:1902223 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process

[Term]
id: GO:0009095
name: aromatic amino acid family biosynthetic process, prephenate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309]
synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT []
synonym: "aromatic amino acid family biosynthetic process via prephenate" EXACT [GOC:pr]
synonym: "aromatic amino acid family biosynthetic process via prephenate(2-)" EXACT [GOC:pr]
synonym: "aromatic amino acid family formation, prephenate pathway" EXACT []
synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT []
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process

[Term]
id: GO:0009097
name: isoleucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
synonym: "isoleucine anabolism" EXACT []
synonym: "isoleucine biosynthesis" EXACT []
synonym: "isoleucine formation" EXACT []
synonym: "isoleucine synthesis" EXACT []
xref: MetaCyc:ILEUSYN-PWY
is_a: GO:0006549 ! isoleucine metabolic process
is_a: GO:0009082 ! branched-chain amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009098
name: L-leucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
synonym: "L-leucine anabolism" EXACT []
synonym: "L-leucine biosynthesis" EXACT []
synonym: "L-leucine formation" EXACT []
synonym: "L-leucine synthesis" EXACT []
synonym: "leucine biosynthetic process" BROAD []
xref: MetaCyc:LEUSYN-PWY
is_a: GO:0006551 ! L-leucine metabolic process
is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process
is_a: GO:0009082 ! branched-chain amino acid biosynthetic process

[Term]
id: GO:0009099
name: L-valine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
synonym: "valine anabolism" EXACT []
synonym: "valine biosynthesis" EXACT []
synonym: "valine formation" EXACT []
synonym: "valine synthesis" EXACT []
xref: MetaCyc:VALSYN-PWY
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process
is_a: GO:0009082 ! branched-chain amino acid biosynthetic process

[Term]
id: GO:0009100
name: glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
subset: goslim_drosophila
synonym: "glycoprotein metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0009101
name: glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
synonym: "glycoprotein anabolism" EXACT []
synonym: "glycoprotein biosynthesis" EXACT []
synonym: "glycoprotein formation" EXACT []
synonym: "glycoprotein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009102
name: biotin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732]
synonym: "biotin anabolism" EXACT []
synonym: "biotin biosynthesis" EXACT []
synonym: "biotin formation" EXACT []
synonym: "biotin synthesis" EXACT []
synonym: "vitamin B7 biosynthesis" EXACT []
synonym: "vitamin B7 biosynthetic process" EXACT []
synonym: "vitamin H biosynthesis" EXACT []
synonym: "vitamin H biosynthetic process" EXACT []
xref: MetaCyc:BIOTIN-SYN
is_a: GO:0006768 ! biotin metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009103
name: lipopolysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr]
synonym: "lipopolysaccharide anabolism" EXACT []
synonym: "lipopolysaccharide biosynthesis" EXACT []
synonym: "lipopolysaccharide formation" EXACT []
synonym: "lipopolysaccharide synthesis" EXACT []
synonym: "LPS biosynthetic process" EXACT []
xref: KEGG_PATHWAY:map00540
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0008653 ! lipopolysaccharide metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009104
name: lipopolysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]
synonym: "lipopolysaccharide breakdown" EXACT []
synonym: "lipopolysaccharide catabolism" EXACT []
synonym: "lipopolysaccharide degradation" EXACT []
synonym: "LPS catabolic process" EXACT []
is_a: GO:0008653 ! lipopolysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009106
name: lipoate metabolic process
namespace: biological_process
alt_id: GO:0000273
def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]
synonym: "lipoate metabolism" EXACT []
synonym: "lipoic acid metabolic process" EXACT []
synonym: "lipoic acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0009107
name: lipoate biosynthetic process
namespace: biological_process
alt_id: GO:0009105
def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]
synonym: "lipoate anabolism" EXACT []
synonym: "lipoate biosynthesis" EXACT []
synonym: "lipoate formation" EXACT []
synonym: "lipoate synthesis" EXACT []
synonym: "lipoic acid anabolism" EXACT []
synonym: "lipoic acid biosynthesis" EXACT []
synonym: "lipoic acid biosynthetic process" EXACT []
synonym: "lipoic acid formation" EXACT []
synonym: "lipoic acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0009106 ! lipoate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0009108
name: obsolete coenzyme biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group biosynthetic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme anabolism" EXACT []
synonym: "coenzyme and prosthetic group biosynthesis" BROAD []
synonym: "coenzyme and prosthetic group biosynthetic process" BROAD []
synonym: "coenzyme biosynthesis" EXACT []
synonym: "coenzyme formation" EXACT []
synonym: "coenzyme synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0009109
name: obsolete coenzyme catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group catabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme and prosthetic group catabolic process" BROAD []
synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "coenzyme breakdown" EXACT []
synonym: "coenzyme catabolism" EXACT []
synonym: "coenzyme degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0009110
name: vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732]
synonym: "vitamin anabolism" EXACT []
synonym: "vitamin biosynthesis" EXACT []
synonym: "vitamin formation" EXACT []
synonym: "vitamin synthesis" EXACT []
is_a: GO:0006766 ! vitamin metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0009111
name: vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body, carried out by individual cells." [GOC:ai]
synonym: "vitamin breakdown" EXACT []
synonym: "vitamin catabolism" EXACT []
synonym: "vitamin degradation" EXACT []
is_a: GO:0006766 ! vitamin metabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0009112
name: nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma]
synonym: "nucleobase metabolism" EXACT []
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0009113
name: purine nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]
synonym: "purine base anabolism" EXACT []
synonym: "purine base biosynthesis" EXACT []
synonym: "purine base biosynthetic process" EXACT [GOC:go_curators]
synonym: "purine base formation" EXACT []
synonym: "purine base synthesis" EXACT []
xref: MetaCyc:PWY-841
is_a: GO:0006144 ! purine nucleobase metabolic process
is_a: GO:0046112 ! nucleobase biosynthetic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0009114
name: hypoxanthine catabolic process
namespace: biological_process
alt_id: GO:0006150
def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [PMID:3196295]
synonym: "hypoxanthine breakdown" EXACT []
synonym: "hypoxanthine catabolism" EXACT []
synonym: "hypoxanthine degradation" EXACT []
synonym: "hypoxanthine oxidation" NARROW []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046100 ! hypoxanthine metabolic process

[Term]
id: GO:0009115
name: xanthine catabolic process
namespace: biological_process
alt_id: GO:0006151
def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
synonym: "xanthine breakdown" EXACT []
synonym: "xanthine catabolism" EXACT []
synonym: "xanthine degradation" EXACT []
synonym: "xanthine oxidation" NARROW []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046110 ! xanthine metabolic process

[Term]
id: GO:0009116
name: nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
subset: goslim_pir
synonym: "nucleoside metabolism" EXACT []
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0009117
name: nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
subset: goslim_pir
synonym: "nucleotide metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009118
name: regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
synonym: "regulation of nucleoside metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009119
name: ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl]
synonym: "ribonucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009120
name: deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
synonym: "deoxyribonucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009123
name: nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside monophosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009124
name: nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside monophosphate anabolism" EXACT []
synonym: "nucleoside monophosphate biosynthesis" EXACT []
synonym: "nucleoside monophosphate formation" EXACT []
synonym: "nucleoside monophosphate synthesis" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009125
name: nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside monophosphate breakdown" EXACT []
synonym: "nucleoside monophosphate catabolism" EXACT []
synonym: "nucleoside monophosphate degradation" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009126
name: purine nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009127
name: purine nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside monophosphate anabolism" EXACT []
synonym: "purine nucleoside monophosphate biosynthesis" EXACT []
synonym: "purine nucleoside monophosphate formation" EXACT []
synonym: "purine nucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process

[Term]
id: GO:0009128
name: purine nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside monophosphate breakdown" EXACT []
synonym: "purine nucleoside monophosphate catabolism" EXACT []
synonym: "purine nucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process

[Term]
id: GO:0009129
name: pyrimidine nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009130
name: pyrimidine nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside monophosphate formation" EXACT []
synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process

[Term]
id: GO:0009131
name: pyrimidine nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process

[Term]
id: GO:0009132
name: nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside diphosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009133
name: nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside diphosphate anabolism" EXACT []
synonym: "nucleoside diphosphate biosynthesis" EXACT []
synonym: "nucleoside diphosphate formation" EXACT []
synonym: "nucleoside diphosphate synthesis" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009134
name: nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside diphosphate breakdown" EXACT []
synonym: "nucleoside diphosphate catabolism" EXACT []
synonym: "nucleoside diphosphate degradation" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009135
name: purine nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009136
name: purine nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside diphosphate anabolism" EXACT []
synonym: "purine nucleoside diphosphate biosynthesis" EXACT []
synonym: "purine nucleoside diphosphate formation" EXACT []
synonym: "purine nucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process

[Term]
id: GO:0009137
name: purine nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside diphosphate breakdown" EXACT []
synonym: "purine nucleoside diphosphate catabolism" EXACT []
synonym: "purine nucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process

[Term]
id: GO:0009138
name: pyrimidine nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009139
name: pyrimidine nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside diphosphate formation" EXACT []
synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process

[Term]
id: GO:0009140
name: pyrimidine nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process

[Term]
id: GO:0009141
name: nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside triphosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009142
name: nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside triphosphate anabolism" EXACT []
synonym: "nucleoside triphosphate biosynthesis" EXACT []
synonym: "nucleoside triphosphate formation" EXACT []
synonym: "nucleoside triphosphate synthesis" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009143
name: nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "nucleoside triphosphate breakdown" EXACT []
synonym: "nucleoside triphosphate catabolism" EXACT []
synonym: "nucleoside triphosphate degradation" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009144
name: purine nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009145
name: purine nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside triphosphate anabolism" EXACT []
synonym: "purine nucleoside triphosphate biosynthesis" EXACT []
synonym: "purine nucleoside triphosphate formation" EXACT []
synonym: "purine nucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process

[Term]
id: GO:0009146
name: purine nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine nucleoside triphosphate breakdown" EXACT []
synonym: "purine nucleoside triphosphate catabolism" EXACT []
synonym: "purine nucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process

[Term]
id: GO:0009147
name: pyrimidine nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009148
name: pyrimidine nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside triphosphate formation" EXACT []
synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process

[Term]
id: GO:0009149
name: pyrimidine nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process

[Term]
id: GO:0009150
name: purine ribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009151
name: purine deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process

[Term]
id: GO:0009152
name: purine ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleotide anabolism" EXACT []
synonym: "purine ribonucleotide biosynthesis" EXACT []
synonym: "purine ribonucleotide formation" EXACT []
synonym: "purine ribonucleotide synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009153
name: purine deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleotide anabolism" EXACT []
synonym: "purine deoxyribonucleotide biosynthesis" EXACT []
synonym: "purine deoxyribonucleotide formation" EXACT []
synonym: "purine deoxyribonucleotide synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009154
name: purine ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleotide breakdown" EXACT []
synonym: "purine ribonucleotide catabolism" EXACT []
synonym: "purine ribonucleotide degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009155
name: purine deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleotide breakdown" EXACT []
synonym: "purine deoxyribonucleotide catabolism" EXACT []
synonym: "purine deoxyribonucleotide degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process
is_a: GO:0046386 ! deoxyribose phosphate catabolic process

[Term]
id: GO:0009156
name: ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside monophosphate anabolism" EXACT []
synonym: "ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "ribonucleoside monophosphate formation" EXACT []
synonym: "ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009157
name: deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside monophosphate formation" EXACT []
synonym: "deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009158
name: ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside monophosphate breakdown" EXACT []
synonym: "ribonucleoside monophosphate catabolism" EXACT []
synonym: "ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009159
name: deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009161
name: ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009162
name: deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009163
name: nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
synonym: "nucleoside anabolism" EXACT []
synonym: "nucleoside biosynthesis" EXACT []
synonym: "nucleoside formation" EXACT []
synonym: "nucleoside synthesis" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034404 ! nucleobase-containing small molecule biosynthetic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0009164
name: nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl]
synonym: "nucleoside breakdown" EXACT []
synonym: "nucleoside catabolism" EXACT []
synonym: "nucleoside degradation" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process
is_a: GO:1901658 ! glycosyl compound catabolic process

[Term]
id: GO:0009165
name: nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
synonym: "nucleotide anabolism" EXACT []
synonym: "nucleotide biosynthesis" EXACT []
synonym: "nucleotide formation" EXACT []
synonym: "nucleotide synthesis" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009166
name: nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
synonym: "nucleotide breakdown" EXACT []
synonym: "nucleotide catabolism" EXACT []
synonym: "nucleotide degradation" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009167
name: purine ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009168
name: purine ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside monophosphate anabolism" EXACT []
synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside monophosphate formation" EXACT []
synonym: "purine ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009169
name: purine ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside monophosphate breakdown" EXACT []
synonym: "purine ribonucleoside monophosphate catabolism" EXACT []
synonym: "purine ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009170
name: purine deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009171
name: purine deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside monophosphate formation" EXACT []
synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process
is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009172
name: purine deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process
is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009173
name: pyrimidine ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009174
name: pyrimidine ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009175
name: pyrimidine ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009176
name: pyrimidine deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009177
name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process
is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009178
name: pyrimidine deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process
is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009179
name: purine ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009180
name: purine ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside diphosphate anabolism" EXACT []
synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside diphosphate formation" EXACT []
synonym: "purine ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process

[Term]
id: GO:0009181
name: purine ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside diphosphate breakdown" EXACT []
synonym: "purine ribonucleoside diphosphate catabolism" EXACT []
synonym: "purine ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process

[Term]
id: GO:0009182
name: purine deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009183
name: purine deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside diphosphate formation" EXACT []
synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process

[Term]
id: GO:0009184
name: purine deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process

[Term]
id: GO:0009185
name: ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009186
name: deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009187
name: cyclic nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
synonym: "cyclic nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0009188
name: ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside diphosphate anabolism" EXACT []
synonym: "ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "ribonucleoside diphosphate formation" EXACT []
synonym: "ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009189
name: deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside diphosphate formation" EXACT []
synonym: "deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009190
name: cyclic nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
synonym: "cyclic nucleotide anabolism" EXACT []
synonym: "cyclic nucleotide biosynthesis" EXACT []
synonym: "cyclic nucleotide formation" EXACT []
synonym: "cyclic nucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0009191
name: ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside diphosphate breakdown" EXACT []
synonym: "ribonucleoside diphosphate catabolism" EXACT []
synonym: "ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009192
name: deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009193
name: pyrimidine ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009194
name: pyrimidine ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process
is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009195
name: pyrimidine ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process
is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009196
name: pyrimidine deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009197
name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process
is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009198
name: pyrimidine deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process
is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009199
name: ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009200
name: deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009201
name: ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside triphosphate anabolism" EXACT []
synonym: "ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "ribonucleoside triphosphate formation" EXACT []
synonym: "ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009202
name: deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside triphosphate formation" EXACT []
synonym: "deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009203
name: ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleoside triphosphate breakdown" EXACT []
synonym: "ribonucleoside triphosphate catabolism" EXACT []
synonym: "ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009204
name: deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009205
name: purine ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009206
name: purine ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside triphosphate anabolism" EXACT []
synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside triphosphate formation" EXACT []
synonym: "purine ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process
is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009207
name: purine ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine ribonucleoside triphosphate breakdown" EXACT []
synonym: "purine ribonucleoside triphosphate catabolism" EXACT []
synonym: "purine ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process
is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009208
name: pyrimidine ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009209
name: pyrimidine ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process
is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009210
name: pyrimidine ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process
is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009211
name: pyrimidine deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process

[Term]
id: GO:0009212
name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009213
name: pyrimidine deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009214
name: cyclic nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
synonym: "cyclic nucleotide breakdown" EXACT []
synonym: "cyclic nucleotide catabolism" EXACT []
synonym: "cyclic nucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0009215
name: purine deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009216
name: purine deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside triphosphate formation" EXACT []
synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process
is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009217
name: purine deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process
is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009218
name: pyrimidine ribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleotide metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009219
name: pyrimidine deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process

[Term]
id: GO:0009220
name: pyrimidine ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleotide anabolism" EXACT []
synonym: "pyrimidine ribonucleotide biosynthesis" EXACT []
synonym: "pyrimidine ribonucleotide formation" EXACT []
synonym: "pyrimidine ribonucleotide synthesis" EXACT []
xref: MetaCyc:PWY0-162
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009221
name: pyrimidine deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleotide formation" EXACT []
synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT []
xref: MetaCyc:PWY0-166
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009222
name: pyrimidine ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine ribonucleotide breakdown" EXACT []
synonym: "pyrimidine ribonucleotide catabolism" EXACT []
synonym: "pyrimidine ribonucleotide degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009223
name: pyrimidine deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleotide degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process
is_a: GO:0046386 ! deoxyribose phosphate catabolic process

[Term]
id: GO:0009224
name: CMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732]
synonym: "CMP anabolism" EXACT []
synonym: "CMP biosynthesis" EXACT []
synonym: "CMP formation" EXACT []
synonym: "CMP synthesis" EXACT []
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046035 ! CMP metabolic process

[Term]
id: GO:0009225
name: nucleotide-sugar metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
subset: goslim_pir
synonym: "nucleotide-sugar metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0009226
name: nucleotide-sugar biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
synonym: "nucleotide-sugar anabolism" EXACT []
synonym: "nucleotide-sugar biosynthesis" EXACT []
synonym: "nucleotide-sugar formation" EXACT []
synonym: "nucleotide-sugar synthesis" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009227
name: nucleotide-sugar catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
synonym: "nucleotide-sugar breakdown" EXACT []
synonym: "nucleotide-sugar catabolism" EXACT []
synonym: "nucleotide-sugar degradation" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009228
name: thiamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732]
synonym: "thiamin anabolism" EXACT []
synonym: "thiamin biosynthetic process" EXACT []
synonym: "thiamine biosynthesis" EXACT []
synonym: "thiamine formation" EXACT []
synonym: "thiamine synthesis" EXACT []
synonym: "vitamin B1 biosynthesis" EXACT []
synonym: "vitamin B1 biosynthetic process" EXACT []
xref: MetaCyc:THISYN-PWY
is_a: GO:0006772 ! thiamine metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042724 ! thiamine-containing compound biosynthetic process

[Term]
id: GO:0009229
name: thiamine diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713]
synonym: "thiamin diphosphate biosynthetic process" EXACT [GOC:cuators]
synonym: "thiamin pyrophosphate biosynthesis" EXACT []
synonym: "thiamin pyrophosphate biosynthetic process" EXACT []
synonym: "thiamine diphosphate anabolism" EXACT []
synonym: "thiamine diphosphate biosynthesis" EXACT []
synonym: "thiamine diphosphate formation" EXACT []
synonym: "thiamine diphosphate synthesis" EXACT []
synonym: "thiamine pyrophosphate biosynthesis" EXACT []
synonym: "thiamine pyrophosphate biosynthetic process" EXACT []
synonym: "TPP biosynthesis" EXACT []
synonym: "TPP biosynthetic process" EXACT []
is_a: GO:0042357 ! thiamine diphosphate metabolic process
is_a: GO:0042724 ! thiamine-containing compound biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0009230
name: thiamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732]
synonym: "thiamin catabolic process" EXACT []
synonym: "thiamine breakdown" EXACT []
synonym: "thiamine catabolism" EXACT []
synonym: "thiamine degradation" EXACT []
synonym: "vitamin B1 catabolic process" EXACT []
synonym: "vitamin B1 catabolism" EXACT []
is_a: GO:0006772 ! thiamine metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0042725 ! thiamine-containing compound catabolic process

[Term]
id: GO:0009231
name: riboflavin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, PMID:10940330]
synonym: "riboflavin anabolism" EXACT []
synonym: "riboflavin biosynthesis" EXACT []
synonym: "riboflavin formation" EXACT []
synonym: "riboflavin synthesis" EXACT []
synonym: "vitamin B2 biosynthesis" EXACT []
synonym: "vitamin B2 biosynthetic process" EXACT []
synonym: "vitamin G biosynthesis" EXACT []
synonym: "vitamin G biosynthetic process" EXACT []
xref: MetaCyc:RIBOSYN2-PWY
xref: Wikipedia:Riboflavin
is_a: GO:0006771 ! riboflavin metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process

[Term]
id: GO:0009232
name: riboflavin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, PMID:10961912]
synonym: "riboflavin breakdown" EXACT []
synonym: "riboflavin catabolism" EXACT []
synonym: "riboflavin degradation" EXACT []
synonym: "vitamin B2 catabolic process" EXACT []
synonym: "vitamin B2 catabolism" EXACT []
synonym: "vitamin G catabolic process" EXACT []
synonym: "vitamin G catabolism" EXACT []
is_a: GO:0006771 ! riboflavin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process

[Term]
id: GO:0009233
name: menaquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, PMID:6127606, PMID:8642453]
synonym: "menaquinone metabolism" EXACT []
synonym: "menatetrenone metabolic process" EXACT []
synonym: "menatetrenone metabolism" EXACT []
synonym: "multiprenylmenaquinone metabolic process" EXACT []
synonym: "multiprenylmenaquinone metabolism" EXACT []
synonym: "vitamin K2 metabolic process" EXACT []
synonym: "vitamin K2 metabolism" EXACT []
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0009234
name: menaquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, PMID:6127606]
synonym: "menaquinone anabolism" EXACT []
synonym: "menaquinone biosynthesis" EXACT []
synonym: "menaquinone formation" EXACT []
synonym: "menaquinone synthesis" EXACT []
synonym: "menatetrenone biosynthesis" EXACT []
synonym: "menatetrenone biosynthetic process" EXACT []
synonym: "multiprenylmenaquinone biosynthesis" EXACT []
synonym: "multiprenylmenaquinone biosynthetic process" EXACT []
synonym: "vitamin K2 biosynthesis" EXACT []
synonym: "vitamin K2 biosynthetic process" EXACT []
xref: MetaCyc:MENAQUINONESYN-PWY
is_a: GO:0009233 ! menaquinone metabolic process
is_a: GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0009235
name: cobalamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
synonym: "cobalamin metabolism" EXACT []
synonym: "vitamin B12 metabolic process" EXACT []
synonym: "vitamin B12 metabolism" EXACT []
synonym: "vitamin B12 reduction" NARROW []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:0009236
name: cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732]
synonym: "cobalamin anabolism" EXACT []
synonym: "cobalamin biosynthesis" EXACT []
synonym: "cobalamin formation" EXACT []
synonym: "cobalamin synthesis" EXACT []
synonym: "vitamin B12 biosynthesis" EXACT []
synonym: "vitamin B12 biosynthetic process" EXACT []
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process

[Term]
id: GO:0009237
name: siderophore metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684]
synonym: "siderochrome metabolic process" NARROW []
synonym: "siderochrome metabolism" NARROW []
synonym: "siderophore metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0009238
name: enterobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684]
synonym: "enterobactin metabolism" EXACT []
synonym: "enterochelin metabolic process" EXACT []
synonym: "enterochelin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0033067 ! macrolide metabolic process

[Term]
id: GO:0009239
name: enterobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031191
alt_id: GO:0031192
def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators]
synonym: "enterobactin anabolism" EXACT []
synonym: "enterobactin biosynthesis" EXACT []
synonym: "enterobactin biosynthetic process, peptide formation" NARROW []
synonym: "enterobactin biosynthetic process, peptide modification" NARROW []
synonym: "enterobactin formation" EXACT []
synonym: "enterobactin synthesis" EXACT []
synonym: "enterobactin synthetase" RELATED []
synonym: "enterochelin biosynthesis" EXACT []
synonym: "enterochelin biosynthetic process" EXACT []
xref: MetaCyc:ENTBACSYN-PWY
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0019540 ! catechol-containing siderophore biosynthetic process
is_a: GO:0033068 ! macrolide biosynthetic process

[Term]
id: GO:0009240
name: isopentenyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732]
synonym: "IPP biosynthesis" EXACT []
synonym: "IPP biosynthetic process" EXACT []
synonym: "isopentenyl diphosphate anabolism" EXACT []
synonym: "isopentenyl diphosphate biosynthesis" EXACT []
synonym: "isopentenyl diphosphate formation" EXACT []
synonym: "isopentenyl diphosphate synthesis" EXACT []
synonym: "isopentenyl pyrophosphate biosynthesis" EXACT []
synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0046490 ! isopentenyl diphosphate metabolic process
relationship: part_of GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:0009242
name: colanic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai]
synonym: "colanic acid anabolism" EXACT []
synonym: "colanic acid biosynthesis" EXACT []
synonym: "colanic acid formation" EXACT []
synonym: "colanic acid synthesis" EXACT []
synonym: "M antigen biosynthesis" EXACT []
synonym: "M antigen biosynthetic process" EXACT []
xref: MetaCyc:COLANSYN-PWY
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0046377 ! colanic acid metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009243
name: O antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732]
synonym: "O antigen anabolism" EXACT []
synonym: "O antigen biosynthesis" EXACT []
synonym: "O antigen formation" EXACT []
synonym: "O antigen synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0046402 ! O antigen metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0009244
name: lipopolysaccharide core region biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732]
synonym: "lipopolysaccharide core region anabolism" EXACT []
synonym: "lipopolysaccharide core region biosynthesis" EXACT []
synonym: "lipopolysaccharide core region formation" EXACT []
synonym: "lipopolysaccharide core region synthesis" EXACT []
synonym: "LPS core region biosynthetic process" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0046401 ! lipopolysaccharide core region metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0009245
name: lipid A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common." [ISBN:0198506732, PMID:20974832, PMID:22216004]
synonym: "lipid A anabolism" EXACT []
synonym: "lipid A biosynthesis" EXACT []
synonym: "lipid A formation" EXACT []
synonym: "lipid A synthesis" EXACT []
xref: MetaCyc:NAGLIPASYN-PWY
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0046493 ! lipid A metabolic process
is_a: GO:1901271 ! lipooligosaccharide biosynthetic process

[Term]
id: GO:0009246
name: enterobacterial common antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma]
synonym: "enterobacterial common antigen anabolism" EXACT []
synonym: "enterobacterial common antigen biosynthesis" EXACT []
synonym: "enterobacterial common antigen formation" EXACT []
synonym: "enterobacterial common antigen synthesis" EXACT []
xref: MetaCyc:ECASYN-PWY
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0046378 ! enterobacterial common antigen metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009247
name: glycolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]
synonym: "glycolipid anabolism" EXACT []
synonym: "glycolipid biosynthesis" EXACT []
synonym: "glycolipid formation" EXACT []
synonym: "glycolipid synthesis" EXACT []
xref: MetaCyc:PWY-401
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046467 ! membrane lipid biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009248
name: K antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732]
synonym: "K antigen anabolism" EXACT []
synonym: "K antigen biosynthesis" EXACT []
synonym: "K antigen formation" EXACT []
synonym: "K antigen synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0046375 ! K antigen metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009249
name: protein lipoylation
namespace: biological_process
alt_id: GO:0018055
def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118]
subset: gocheck_obsoletion_candidate
synonym: "peptidyl-lysine lipoylation" EXACT []
synonym: "protein-lipoic acid cofactor linkage" EXACT []
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0009250
name: glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
synonym: "glucan anabolism" EXACT []
synonym: "glucan biosynthesis" EXACT []
synonym: "glucan formation" EXACT []
synonym: "glucan synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0009251
name: glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
synonym: "glucan breakdown" EXACT []
synonym: "glucan catabolism" EXACT []
synonym: "glucan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0009252
name: peptidoglycan biosynthetic process
namespace: biological_process
alt_id: GO:0009285
def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [ISBN:0198506732, PMID:18266853]
synonym: "murein biosynthesis" EXACT []
synonym: "murein biosynthetic process" EXACT []
synonym: "peptidoglycan anabolism" EXACT []
synonym: "peptidoglycan biosynthesis" EXACT []
synonym: "peptidoglycan formation" EXACT []
synonym: "peptidoglycan synthesis" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0009253
name: peptidoglycan catabolic process
namespace: biological_process
alt_id: GO:0009286
def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [ISBN:0198506732, PMID:9158729]
synonym: "murein catabolic process" EXACT []
synonym: "murein catabolism" EXACT []
synonym: "peptidoglycan breakdown" EXACT []
synonym: "peptidoglycan catabolism" EXACT []
synonym: "peptidoglycan degradation" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process
is_a: GO:0006027 ! glycosaminoglycan catabolic process

[Term]
id: GO:0009254
name: peptidoglycan turnover
namespace: biological_process
alt_id: GO:0009287
def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl]
synonym: "murein turnover" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process

[Term]
id: GO:0009255
name: Entner-Doudoroff pathway through 6-phosphogluconate
namespace: biological_process
def: "A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, MetaCyc:PWY-8004, PMID:12921356, PMID:12981024]
xref: MetaCyc:PWY-8004
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0061678 ! Entner-Doudoroff pathway

[Term]
id: GO:0009256
name: 10-formyltetrahydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
synonym: "10-formyl-THF metabolic process" EXACT []
synonym: "10-formyl-THF metabolism" EXACT []
synonym: "10-formyltetrahydrofolate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046653 ! tetrahydrofolate metabolic process

[Term]
id: GO:0009257
name: 10-formyltetrahydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
synonym: "10-formyl-THF biosynthesis" EXACT []
synonym: "10-formyl-THF biosynthetic process" EXACT []
synonym: "10-formyltetrahydrofolate anabolism" EXACT []
synonym: "10-formyltetrahydrofolate biosynthesis" EXACT []
synonym: "10-formyltetrahydrofolate formation" EXACT []
synonym: "10-formyltetrahydrofolate synthesis" EXACT []
is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046654 ! tetrahydrofolate biosynthetic process

[Term]
id: GO:0009258
name: 10-formyltetrahydrofolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
synonym: "10-formyl-THF catabolic process" EXACT []
synonym: "10-formyl-THF catabolism" EXACT []
synonym: "10-formyltetrahydrofolate breakdown" EXACT []
synonym: "10-formyltetrahydrofolate catabolism" EXACT []
synonym: "10-formyltetrahydrofolate degradation" EXACT []
is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process
is_a: GO:0009397 ! folic acid-containing compound catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0009259
name: ribonucleotide metabolic process
namespace: biological_process
alt_id: GO:0009121
def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0019693 ! ribose phosphate metabolic process

[Term]
id: GO:0009260
name: ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleotide anabolism" EXACT []
synonym: "ribonucleotide biosynthesis" EXACT []
synonym: "ribonucleotide formation" EXACT []
synonym: "ribonucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009259 ! ribonucleotide metabolic process
is_a: GO:0046390 ! ribose phosphate biosynthetic process

[Term]
id: GO:0009261
name: ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "ribonucleotide breakdown" EXACT []
synonym: "ribonucleotide catabolism" EXACT []
synonym: "ribonucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009262
name: deoxyribonucleotide metabolic process
namespace: biological_process
alt_id: GO:0009122
alt_id: GO:0009393
def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0009263
name: deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleotide anabolism" EXACT []
synonym: "deoxyribonucleotide biosynthesis" EXACT []
synonym: "deoxyribonucleotide formation" EXACT []
synonym: "deoxyribonucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009264
name: deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
synonym: "deoxyribonucleotide breakdown" EXACT []
synonym: "deoxyribonucleotide catabolism" EXACT []
synonym: "deoxyribonucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009265
name: 2'-deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]
synonym: "2'-deoxyribonucleotide anabolism" EXACT []
synonym: "2'-deoxyribonucleotide biosynthesis" EXACT []
synonym: "2'-deoxyribonucleotide formation" EXACT []
synonym: "2'-deoxyribonucleotide synthesis" EXACT []
is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process

[Term]
id: GO:0009266
name: response to temperature stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]
synonym: "response to thermal stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009267
name: cellular response to starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0009268
name: response to pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:jl, Wikipedia:PH]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009269
name: response to desiccation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl]
synonym: "desiccation tolerance" RELATED []
is_a: GO:0009414 ! response to water deprivation

[Term]
id: GO:0009270
name: response to humidity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl]
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009271
name: phage shock
namespace: biological_process
def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0009272
name: fungal-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu]
synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [GOC:mah]
synonym: "fungal-type cell wall anabolism" RELATED [GOC:mah]
synonym: "fungal-type cell wall biosynthetic process" RELATED [GOC:mah]
synonym: "fungal-type cell wall formation" RELATED [GOC:mah]
synonym: "fungal-type cell wall synthesis" RELATED [GOC:mah]
is_a: GO:0042546 ! cell wall biogenesis
is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis

[Term]
id: GO:0009273
name: peptidoglycan-based cell wall biogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators]
synonym: "cell envelope biosynthesis" BROAD []
synonym: "cell envelope biosynthetic process" BROAD []
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
is_a: GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0009274
name: peptidoglycan-based cell wall
namespace: cellular_component
def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893]
synonym: "envelope" BROAD []
synonym: "murein sacculus" RELATED []
synonym: "peptidoglycan" NARROW []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009275
name: Gram-positive-bacterium-type cell wall
namespace: cellular_component
def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0815108893]
synonym: "20-80nm peptidoglycan-based cell wall" EXACT []
synonym: "cell wall of Gram-positive Bacteria" EXACT []
is_a: GO:0009274 ! peptidoglycan-based cell wall

[Term]
id: GO:0009276
name: Gram-negative-bacterium-type cell wall
namespace: cellular_component
def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893]
subset: goslim_metagenomics
synonym: "1-2nm peptidoglycan-based cell wall" EXACT []
synonym: "cell wall inner membrane" EXACT []
is_a: GO:0009274 ! peptidoglycan-based cell wall
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009277
name: fungal-type cell wall
namespace: cellular_component
def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422]
synonym: "beta-glucan-containing cell wall" RELATED []
synonym: "chitin- and beta-glucan-containing cell wall" NARROW []
synonym: "chitin-containing cell wall" RELATED []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009278
name: obsolete murein sacculus
namespace: cellular_component
def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "murein sacculus" EXACT []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0009279
name: cell outer membrane
namespace: cellular_component
def: "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:md, GOC:mtg_sensu, ISBN:0135712254]
comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886.
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "outer membrane of cell" EXACT []
is_a: GO:0019867 ! outer membrane
relationship: part_of GO:0030312 ! external encapsulating structure
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009280
name: obsolete cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "cell wall inner membrane" EXACT []
synonym: "cytoplasmic membrane" BROAD []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0009288
name: bacterial-type flagellum
namespace: cellular_component
def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, PMID:7787060, Wikipedia:Flagellum#Bacterial]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "flagellin-based flagellum" EXACT []
xref: Wikipedia:Flagellum#Bacterial
is_a: GO:0042995 ! cell projection
is_a: GO:0043228 ! membraneless organelle

[Term]
id: GO:0009289
name: pilus
namespace: cellular_component
def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators, PMID:28496159]
subset: goslim_pir
synonym: "fimbria" EXACT []
synonym: "fimbriae" EXACT []
synonym: "fimbrium" EXACT []
synonym: "pili" EXACT []
xref: Wikipedia:Pilus
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0009290
name: DNA import into cell involved in transformation
namespace: biological_process
def: "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai]
synonym: "cellular DNA import during transformation" RELATED []
synonym: "cellular DNA uptake" BROAD []
synonym: "DNA import into cell" BROAD []
synonym: "DNA transport into cell during transformation" RELATED []
is_a: GO:0051027 ! DNA transport
is_a: GO:0098657 ! import into cell
relationship: part_of GO:0009294 ! DNA-mediated transformation

[Term]
id: GO:0009291
name: unidirectional conjugation
namespace: biological_process
def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells. Some or all of the chromosome(s) of the donor cell is transferred into the recipient cell." [Wikipedia:Bacterial_conjugation]
comment: Unidirectional conjugation is not a type of not sexual reproduction, since no exchange of gamete occurs and no generation of a new organism: instead an existing organism is transformed.
subset: goslim_pir
synonym: "bacterial conjugation" RELATED []
xref: Wikipedia:Bacterial_conjugation
is_a: GO:0009292 ! horizontal gene transfer

[Term]
id: GO:0009292
name: horizontal gene transfer
namespace: biological_process
def: "The introduction of genetic information into a cell to create a genetically different individual, without production of new individuals." [PMID:26184597]
subset: goslim_pir
synonym: "genetic exchange" BROAD []
synonym: "genetic transfer" EXACT []
synonym: "lateral gene transfer" EXACT []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0009293
name: transduction
namespace: biological_process
def: "A type of horizontal gene transfer in which genetic material is introduced into a cell mediated by a virus." [PMID:18265289, PMID:33597173]
comment: This process occurs both in prokaryotes and in eukaryotes.
xref: Wikipedia:Transduction_(genetics)
is_a: GO:0009292 ! horizontal gene transfer

[Term]
id: GO:0009294
name: DNA-mediated transformation
namespace: biological_process
def: "The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope." [PMID:12706993, PMID:24509783, PMID:27826682]
synonym: "DNA mediated transformation" EXACT []
is_a: GO:0009292 ! horizontal gene transfer

[Term]
id: GO:0009295
name: nucleoid
namespace: cellular_component
def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689]
xref: Wikipedia:Nucleoid
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0009296
name: obsolete flagellum assembly
namespace: biological_process
def: "OBSOLETE. The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [GOC:curators, ISBN:0815316194]
synonym: "flagella assembly" EXACT [GOC:mah]
synonym: "flagella biogenesis" RELATED []
synonym: "flagellum assembly" EXACT []
synonym: "flagellum biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0044780
consider: GO:0060271

[Term]
id: GO:0009297
name: pilus assembly
namespace: biological_process
def: "The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb]
synonym: "fimbria assembly" NARROW []
synonym: "fimbria biogenesis" RELATED []
synonym: "fimbriae assembly" NARROW []
synonym: "fimbriae biogenesis" RELATED []
synonym: "fimbrial assembly" NARROW []
synonym: "fimbrium assembly" NARROW []
synonym: "fimbrium biogenesis" RELATED []
synonym: "pilus biogenesis" RELATED []
synonym: "pilus formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0043711 ! pilus organization

[Term]
id: GO:0009298
name: GDP-mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-mannose anabolism" EXACT []
synonym: "GDP-mannose biosynthesis" EXACT []
synonym: "GDP-mannose formation" EXACT []
synonym: "GDP-mannose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019673 ! GDP-mannose metabolic process

[Term]
id: GO:0009299
name: mRNA transcription
namespace: biological_process
alt_id: GO:0061023
def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl]
synonym: "cellular mRNA transcription" EXACT []
synonym: "mRNA biosynthesis" BROAD []
synonym: "mRNA biosynthetic process" BROAD []
synonym: "mRNA synthesis" BROAD []
is_a: GO:0006351 ! DNA-templated transcription
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0009300
name: antisense RNA transcription
namespace: biological_process
def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl]
is_a: GO:0006351 ! DNA-templated transcription
is_a: GO:0042868 ! antisense RNA metabolic process

[Term]
id: GO:0009301
name: snRNA transcription
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382]
is_a: GO:0006351 ! DNA-templated transcription
is_a: GO:0016073 ! snRNA metabolic process

[Term]
id: GO:0009302
name: sno(s)RNA transcription
namespace: biological_process
def: "The synthesis of snoRNA class RNA (also referred to as sRNA in Archaea) from a DNA template." [GOC:jl, GOC:krc, PMID:17284456]
synonym: "snoRNA transcription" NARROW []
synonym: "sRNA transcription" NARROW []
is_a: GO:0006351 ! DNA-templated transcription
is_a: GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:0009303
name: rRNA transcription
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]
synonym: "rRNA biosynthesis" BROAD []
synonym: "rRNA biosynthetic process" BROAD []
synonym: "rRNA synthesis" BROAD []
is_a: GO:0006351 ! DNA-templated transcription
is_a: GO:0016072 ! rRNA metabolic process

[Term]
id: GO:0009304
name: tRNA transcription
namespace: biological_process
def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl]
synonym: "tRNA biosynthesis" BROAD []
synonym: "tRNA biosynthetic process" BROAD []
synonym: "tRNA synthesis" BROAD []
is_a: GO:0006351 ! DNA-templated transcription
is_a: GO:0006399 ! tRNA metabolic process

[Term]
id: GO:0009305
name: obsolete protein biotinylation
namespace: biological_process
def: "OBSOLETE. The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai]
comment: This terms was obsoleted because it represents a molecular function as a biological process.
synonym: "protein amino acid biotinylation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0009306
name: protein secretion
namespace: biological_process
alt_id: GO:0045166
alt_id: GO:0045731
def: "The controlled release of proteins from a cell." [GOC:ai]
synonym: "glycoprotein secretion" NARROW []
synonym: "protein secretion during cell fate commitment" NARROW []
synonym: "protein secretion resulting in cell fate commitment" NARROW []
is_a: GO:0015031 ! protein transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0035592 ! establishment of protein localization to extracellular region

[Term]
id: GO:0009307
name: DNA restriction-modification system
namespace: biological_process
def: "A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme." [GOC:jl, UniProtKB-KW:KW-0680]
synonym: "DNA restriction" BROAD []
is_a: GO:0006304 ! DNA modification
is_a: GO:0044355 ! clearance of foreign intracellular DNA

[Term]
id: GO:0009308
name: amine metabolic process
namespace: biological_process
alt_id: GO:0044106
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
synonym: "amine metabolism" EXACT []
synonym: "cellular amine metabolic process" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009309
name: amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
synonym: "amine anabolism" EXACT []
synonym: "amine biosynthesis" EXACT []
synonym: "amine formation" EXACT []
synonym: "amine synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0009310
name: amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
synonym: "amine breakdown" EXACT []
synonym: "amine catabolism" EXACT []
synonym: "amine degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0009311
name: oligosaccharide metabolic process
namespace: biological_process
alt_id: GO:0051690
def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
subset: goslim_yeast
synonym: "multicellular organismal oligosaccharide metabolic process" NARROW []
synonym: "oligosaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0009312
name: oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
synonym: "oligosaccharide anabolism" EXACT []
synonym: "oligosaccharide biosynthesis" EXACT []
synonym: "oligosaccharide formation" EXACT []
synonym: "oligosaccharide synthesis" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0009313
name: oligosaccharide catabolic process
namespace: biological_process
alt_id: GO:0051689
def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
synonym: "multicellular organismal oligosaccharide catabolic process" NARROW []
synonym: "oligosaccharide breakdown" EXACT []
synonym: "oligosaccharide catabolism" EXACT []
synonym: "oligosaccharide degradation" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0009314
name: response to radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
synonym: "response to electromagnetic radiation stimulus" EXACT []
synonym: "response to radiation stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009315
name: obsolete drug resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "drug resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009410

[Term]
id: GO:0009316
name: 3-isopropylmalate dehydratase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530]
comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'.
synonym: "isopropylmalate isomerase complex" EXACT []
xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0009317
name: acetyl-CoA carboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "ACCase complex" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009318
name: exodeoxyribonuclease VII complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [PMID:6284744]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009319
name: cytochrome o ubiquinol oxidase complex
namespace: cellular_component
def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268]
comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'.
xref: MetaCyc:CYT-O-UBIOX-CPLX
is_a: GO:0070069 ! cytochrome complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902495 ! transmembrane transporter complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009320
name: phosphoribosylaminoimidazole carboxylase complex
namespace: cellular_component
def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah]
comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'.
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009321
name: alkyl hydroperoxide reductase complex
namespace: cellular_component
def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [GOC:jl, PMID:2649484]
comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009322
name: obsolete trimethylamine-N-oxide reductase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this complex exists.
is_obsolete: true
consider: GO:1904852

[Term]
id: GO:0009323
name: obsolete ribosomal-protein-alanine N-acetyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this complex exists. Enzymes with that activity, such as E. coli rimJ (UniProt:P0A948), act as monomers.
is_obsolete: true

[Term]
id: GO:0009324
name: D-amino-acid dehydrogenase complex
namespace: cellular_component
def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah]
comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'.
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009325
name: nitrate reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [PMID:2139607]
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009326
name: formate dehydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [PMID:1504073, PMID:8566699]
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009327
name: obsolete NAD(P)+ transhydrogenase complex (AB-specific)
namespace: cellular_component
def: "OBSOLETE. A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [GOC:mah]
comment: This term was obsoleted because there is no evidence that this activity exists as part of a complex.
is_obsolete: true

[Term]
id: GO:0009328
name: phenylalanine-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [PMID:20223217]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009329
name: acetate CoA-transferase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010]
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex

[Term]
id: GO:0009330
name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
namespace: cellular_component
def: "Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:Type_II_topoisomerase]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009331
name: glycerol-3-phosphate dehydrogenase (FAD) complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions." [PMID:18296637, PMID:3286606, PMID:7576488]
synonym: "aerobic glycerol 3-phosphate dehydrogenase" NARROW []
synonym: "anaerobic glycerol-3-phosphate dehydrogenase" NARROW []
synonym: "glycerol-3-phosphate dehydrogenase complex" BROAD []
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009332
name: glutamate-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [PMID:29679766]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009333
name: cysteine synthase complex
namespace: cellular_component
def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [PMID:10993149]
xref: MetaCyc:CYSSYNMULTI-CPLX
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009334
name: 3-phenylpropionate dioxygenase complex
namespace: cellular_component
def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882]
comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'.
xref: MetaCyc:HCAMULTI-CPLX
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009335
name: obsolete holo-[acyl-carrier protein] synthase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term.
synonym: "holo-[acyl-carrier protein] synthase complex" EXACT []
synonym: "holo-ACP synthase complex" EXACT []
is_obsolete: true
consider: GO:0005835

[Term]
id: GO:0009336
name: sulfate adenylyltransferase complex (ATP)
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [PMID:15184554]
synonym: "sulphate adenylyltransferase complex (ATP)" EXACT []
is_a: GO:1902503 ! adenylyltransferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009337
name: sulfite reductase complex (NADPH)
namespace: cellular_component
def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [GOC:jl, PMID:6751400]
comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'.
synonym: "sulphite reductase complex (NADPH)" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009338
name: exodeoxyribonuclease V complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [PMID:1618858]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009339
name: glycolate oxidase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [PMID:4557653, PMID:8606183]
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009340
name: DNA topoisomerase IV complex
namespace: cellular_component
def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632]
is_a: GO:0009330 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

[Term]
id: GO:0009341
name: beta-galactosidase complex
namespace: cellular_component
def: "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [PMID:15950161]
subset: goslim_metagenomics
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009342
name: glutamate synthase complex (NADPH)
namespace: cellular_component
def: "A complex that possesses glutamate synthase (NADPH) activity." [GOC:mah, PMID:4565085]
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0009343
name: obsolete biotin carboxylase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14]
comment: This term was obsoleted because it represents a homomer.
is_obsolete: true

[Term]
id: GO:0009344
name: nitrite reductase complex [NAD(P)H]
namespace: cellular_component
def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah]
comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'.
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009345
name: glycine-tRNA ligase complex
namespace: cellular_component
def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [PMID:15733854]
synonym: "glycine-tRNA synthetase complex" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009346
name: ATP-independent citrate lyase complex
namespace: cellular_component
def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria." [PMID:32302313]
comment: Note that this complex has only been found in bacteria. For eukaryotic cytrate lyases, consider GO:0140615 ; ATP-dependent citrate lyase complex.
subset: goslim_metagenomics
synonym: "citrate lyase complex" BROAD []
synonym: "citrate synthase complex" BROAD []
xref: MetaCyc:ACECITLY-CPLX
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009347
name: aspartate carbamoyltransferase complex
namespace: cellular_component
def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693]
comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0009348
name: obsolete ornithine carbamoyltransferase complex
namespace: cellular_component
def: "OBSOLETE. A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah]
comment: This term was obsoleted because it represents a homomer.
is_obsolete: true

[Term]
id: GO:0009349
name: riboflavin synthase complex
namespace: cellular_component
def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [PMID:18298940]
subset: goslim_metagenomics
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0009350
name: ethanolamine ammonia-lyase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [PMID:1550360]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009351
name: obsolete dihydrolipoamide S-acyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12]
comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide.
synonym: "dihydrolipoamide S-acyltransferase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0009352
name: obsolete dihydrolipoyl dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah]
comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself.
synonym: "dihydrolipoamide dehydrogenase complex" EXACT []
synonym: "dihydrolipoyl dehydrogenase complex" EXACT []
is_obsolete: true
consider: GO:0004148
consider: GO:0045240
consider: GO:0045254

[Term]
id: GO:0009353
name: obsolete mitochondrial oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A mitochondrial complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix." [GOC:mtg_sensu, PMID:10848975]
comment: This term is unnecessarily taxon-specific.
is_obsolete: true
replaced_by: GO:0045252

[Term]
id: GO:0009354
name: obsolete dihydrolipoamide S-succinyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61]
comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide.
synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT []
is_obsolete: true
consider: GO:0045252

[Term]
id: GO:0009355
name: DNA polymerase V complex
namespace: cellular_component
def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196]
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009356
name: aminodeoxychorismate synthase complex
namespace: cellular_component
def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344]
synonym: "4-amino-4-deoxychorismate synthase complex" RELATED []
synonym: "ADC synthase complex" EXACT []
synonym: "p-aminobenzoate synthetase complex" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009357
name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [PMID:2951378]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:0009358
name: polyphosphate kinase complex
namespace: cellular_component
def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah]
comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'.
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0009359
name: type II site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
synonym: "type II restriction enzyme complex" EXACT []
is_a: GO:1905347 ! endodeoxyribonuclease complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009360
name: DNA polymerase III complex
namespace: cellular_component
def: "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710]
synonym: "DNA polymerase III holoenzyme complex" EXACT []
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009361
name: succinate-CoA ligase complex (ADP-forming)
namespace: cellular_component
def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [GOC:jl, PMID:9874242]
synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394]
is_a: GO:0042709 ! succinate-CoA ligase complex

[Term]
id: GO:0009365
name: protein histidine kinase complex
namespace: cellular_component
def: "A complex that possesses protein histidine kinase activity." [GOC:mah]
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:0009366
name: enterobactin synthetase complex
namespace: cellular_component
def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [PMID:9485415]
synonym: "enterochelin synthetase complex" EXACT []
xref: MetaCyc:ENTMULTI-CPLX
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009367
name: obsolete prepilin peptidase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43]
comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer.
synonym: "prepilin peptidase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0009368
name: endopeptidase Clp complex
namespace: cellular_component
def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464]
subset: goslim_pir
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009371
name: obsolete positive regulation of transcription by pheromones
namespace: biological_process
def: "OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription by pheromones" NARROW []
synonym: "stimulation of transcription by pheromones" NARROW []
synonym: "up regulation of transcription by pheromones" EXACT []
synonym: "up-regulation of transcription by pheromones" EXACT []
synonym: "upregulation of transcription by pheromones" EXACT []
is_obsolete: true

[Term]
id: GO:0009372
name: quorum sensing
namespace: biological_process
alt_id: GO:0010699
alt_id: GO:0060247
def: "The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms." [GOC:krc, GOC:mlg, PMID:10607620, PMID:15716452, PMID:16497924, PMID:16630813, PMID:8288518]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "cell-cell signaling involved in quorum sensing" RELATED []
synonym: "detection of cell density by secreted molecule" RELATED []
synonym: "quorum sensing system" EXACT []
xref: Wikipedia:Quorum_sensing
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0060245 ! detection of cell density

[Term]
id: GO:0009373
name: obsolete regulation of transcription by pheromones
namespace: biological_process
def: "OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators]
comment: This term has been obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0009374
name: biotin binding
namespace: molecular_function
def: "Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]
synonym: "vitamin B7 binding" EXACT []
synonym: "vitamin H binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0009375
name: ferredoxin hydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [PMID:12792025, PMID:9836629]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009376
name: HslUV protease complex
namespace: cellular_component
def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer." [GOC:bhm, PMID:12670962, UniProt:P0A6H5]
synonym: "ClpYQ protease complex" EXACT []
is_a: GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0009377
name: obsolete HslUV protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141]
comment: This term was made obsolete because it represents a gene product.
synonym: "HslUV protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008233

[Term]
id: GO:0009378
name: four-way junction helicase activity
namespace: molecular_function
alt_id: GO:1990163
def: "Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis." [GOC:al, PMID:22723423, PMID:9442895]
synonym: "ATP-dependent four-way junction DNA helicase activity" EXACT []
synonym: "ATP-dependent four-way junction helicase activity" EXACT []
synonym: "ATP-dependent Holliday junction helicase activity" NARROW []
synonym: "Holliday junction helicase activity" NARROW []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0009379
name: Holliday junction helicase complex
namespace: cellular_component
def: "A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA." [PMID:16935884, PMID:9442895]
is_a: GO:0033202 ! DNA helicase complex

[Term]
id: GO:0009380
name: excinuclease repair complex
namespace: cellular_component
def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:12145219, PMID:15192705]
synonym: "excinuclease ABC complex" EXACT []
synonym: "UvrABC excinuclease complex" EXACT []
is_a: GO:1905347 ! endodeoxyribonuclease complex
is_a: GO:1990391 ! DNA repair complex

[Term]
id: GO:0009381
name: excinuclease ABC activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705]
is_a: GO:0004520 ! DNA endonuclease activity

[Term]
id: GO:0009382
name: imidazoleglycerol-phosphate synthase complex
namespace: cellular_component
def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah]
comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'.
synonym: "imidazoleglycerol phosphate synthase complex" EXACT []
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009383
name: rRNA (cytosine-C5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544]
synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW []
synonym: "rRNA m5C967 methyltransferase activity" NARROW []
xref: Reactome:R-HSA-6790944 "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447"
xref: Reactome:R-HSA-6793057 "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841"
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity

[Term]
id: GO:0009384
name: N-acylmannosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60]
synonym: "acetylamidodeoxymannokinase activity" RELATED [EC:2.7.1.60]
synonym: "acetylmannosamine kinase activity" RELATED [EC:2.7.1.60]
synonym: "acylaminodeoxymannokinase activity" RELATED [EC:2.7.1.60]
synonym: "acylmannosamine kinase (phosphorylating)" RELATED [EC:2.7.1.60]
synonym: "acylmannosamine kinase activity" RELATED [EC:2.7.1.60]
synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" RELATED [EC:2.7.1.60]
synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" RELATED [EC:2.7.1.60]
synonym: "N-acetylmannosamine kinase activity" RELATED [EC:2.7.1.60]
synonym: "N-acyl-D-mannosamine kinase activity" RELATED [EC:2.7.1.60]
xref: EC:2.7.1.60
xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN
xref: Reactome:R-HSA-4085028 "GNE phosphorylates ManNAc to ManNAc-6-P"
xref: Reactome:R-HSA-4088322 "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P"
xref: RHEA:23832
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0009385
name: obsolete N-acylmannosamine-6-phosphate 2-epimerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as N-acylglucosamine-6-phosphate 2-epimerase activity ; GO:0047465.
synonym: "N-acylmannosamine-6-P epimerase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047465

[Term]
id: GO:0009386
name: translational attenuation
namespace: biological_process
def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513]
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0009388
name: obsolete antisense RNA
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "antisense RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0009389
name: dimethyl sulfoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [PMID:8658134]
synonym: "dimethyl sulphoxide reductase activity" EXACT []
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0009390
name: dimethyl sulfoxide reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [PMID:21357619, PMID:3280546]
synonym: "dimethyl sulphoxide reductase complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0009392
name: N-acetyl-anhydromuramoyl-L-alanine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala." [MetaCyc:RXN0-5225]
xref: MetaCyc:RXN0-5225
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0009394
name: 2'-deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]
synonym: "2'-deoxyribonucleotide metabolism" EXACT []
is_a: GO:0009262 ! deoxyribonucleotide metabolic process
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0009395
name: phospholipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
synonym: "phospholipid breakdown" EXACT []
synonym: "phospholipid catabolism" EXACT []
synonym: "phospholipid degradation" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0009396
name: folic acid-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]
synonym: "folate and derivative biosynthesis" EXACT []
synonym: "folate and derivative biosynthetic process" EXACT []
synonym: "folate-containing compound biosynthesis" EXACT []
synonym: "folate-containing compound biosynthetic process" EXACT []
synonym: "folic acid and derivative biosynthesis" EXACT []
synonym: "folic acid and derivative biosynthetic process" EXACT []
synonym: "folic acid-containing compound anabolism" EXACT []
synonym: "folic acid-containing compound biosynthesis" EXACT []
synonym: "folic acid-containing compound formation" EXACT []
synonym: "folic acid-containing compound synthesis" EXACT []
synonym: "vitamin B9 and derivative biosynthesis" EXACT []
synonym: "vitamin B9 and derivative biosynthetic process" EXACT []
synonym: "vitamin M and derivative biosynthesis" EXACT []
synonym: "vitamin M and derivative biosynthetic process" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process

[Term]
id: GO:0009397
name: folic acid-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai]
synonym: "folate and derivative catabolic process" EXACT []
synonym: "folate and derivative catabolism" EXACT []
synonym: "folate-containing compound catabolic process" EXACT []
synonym: "folate-containing compound catabolism" EXACT []
synonym: "folic acid and derivative catabolic process" EXACT []
synonym: "folic acid and derivative catabolism" EXACT []
synonym: "folic acid-containing compound breakdown" EXACT []
synonym: "folic acid-containing compound catabolism" EXACT []
synonym: "folic acid-containing compound degradation" EXACT []
synonym: "vitamin B9 and derivative catabolic process" EXACT []
synonym: "vitamin B9 and derivative catabolism" EXACT []
synonym: "vitamin M and derivative catabolic process" EXACT []
synonym: "vitamin M and derivative catabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process

[Term]
id: GO:0009398
name: FMN biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai]
synonym: "FMN anabolism" EXACT []
synonym: "FMN biosynthesis" EXACT []
synonym: "FMN formation" EXACT []
synonym: "FMN synthesis" EXACT []
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process
is_a: GO:0046444 ! FMN metabolic process

[Term]
id: GO:0009399
name: nitrogen fixation
namespace: biological_process
def: "The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation]
xref: MetaCyc:N2FIX-PWY
xref: Wikipedia:Nitrogen_fixation
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0009400
name: obsolete signal transducer, downstream of receptor, with serine/threonine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf, GOC:mah]
comment: This term was obsoleted because it was not clearly defined.
synonym: "receptor signaling protein serine/threonine phosphatase activity" EXACT []
synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0009401
name: phosphoenolpyruvate-dependent sugar phosphotransferase system
namespace: biological_process
def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [PMID:31209249, PMID:33820910]
synonym: "PTS system" NARROW []
is_a: GO:0098704 ! carbohydrate import across plasma membrane

[Term]
id: GO:0009402
name: obsolete toxin resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "toxin resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009636

[Term]
id: GO:0009403
name: toxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators]
subset: goslim_metagenomics
synonym: "toxin anabolism" EXACT []
synonym: "toxin biosynthesis" EXACT []
synonym: "toxin formation" EXACT []
synonym: "toxin synthesis" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0009404
name: toxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]
subset: goslim_pir
synonym: "toxin metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0009405
name: obsolete pathogenesis
namespace: biological_process
def: "OBSOLETE. The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism." [GOC:go_curators]
comment: This term was obsoleted because it does not describe a single, normal biological process; rather it is the effect of an interaction between two organisms, under specific conditions.
synonym: "virulence" RELATED []
is_obsolete: true
consider: GO:0044003
consider: GO:0052031
consider: GO:0052042

[Term]
id: GO:0009406
name: obsolete virulence
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a phenotype rather than a biological process.
synonym: "virulence" EXACT []
is_obsolete: true
consider: GO:0016032
consider: GO:0090729

[Term]
id: GO:0009407
name: toxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators]
synonym: "toxin breakdown" EXACT []
synonym: "toxin catabolism" EXACT []
synonym: "toxin degradation" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0098754 ! detoxification

[Term]
id: GO:0009408
name: response to heat
namespace: biological_process
alt_id: GO:0006951
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
subset: goslim_yeast
synonym: "response to heat shock" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0009409
name: response to cold
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]
synonym: "freezing tolerance" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0009410
name: response to xenobiotic stimulus
namespace: biological_process
alt_id: GO:0017035
alt_id: GO:0017104
alt_id: GO:0042493
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc]
subset: goslim_candida
synonym: "drug resistance" RELATED []
synonym: "drug susceptibility/resistance" RELATED []
synonym: "response to drug" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0009411
name: response to UV
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
synonym: "response to ultraviolet light stimulus" EXACT []
synonym: "response to ultraviolet radiation stimulus" EXACT []
synonym: "response to UV light stimulus" EXACT []
synonym: "response to UV radiation stimulus" EXACT []
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009412
name: obsolete response to heavy metal
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "response to heavy metal" EXACT []
is_obsolete: true
consider: GO:0010038

[Term]
id: GO:0009413
name: response to flooding
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr]
comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle.
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009414
name: response to water deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr]
synonym: "drought tolerance" RELATED []
synonym: "response to dehydration" EXACT []
synonym: "response to drought" EXACT []
synonym: "response to thirst" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009415
name: response to water
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl]
synonym: "response to water stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009416
name: response to light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
subset: goslim_plant
is_a: GO:0009314 ! response to radiation

[Term]
id: GO:0009417
name: obsolete fimbrin
namespace: cellular_component
def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "fimbrin" EXACT []
is_obsolete: true
replaced_by: GO:0009289

[Term]
id: GO:0009418
name: pilus shaft
namespace: cellular_component
def: "The long, slender, mid section of a pilus." [GOC:jl]
synonym: "fimbrial shaft" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009289 ! pilus

[Term]
id: GO:0009419
name: pilus tip
namespace: cellular_component
def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl]
synonym: "fimbrial tip" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009289 ! pilus

[Term]
id: GO:0009420
name: bacterial-type flagellum filament
namespace: cellular_component
def: "The long (approximately 20 nm), thin external structure of the bacterial-type flagellum, which acts as a propeller." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar filament" EXACT []
synonym: "flagellin-based flagellum filament" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009288 ! bacterial-type flagellum

[Term]
id: GO:0009421
name: bacterial-type flagellum filament cap
namespace: cellular_component
def: "The proteinaceous structure at the distal tip of the bacterial-type flagellar filament." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar filament cap" EXACT []
synonym: "flagellin-based flagellum filament cap" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009420 ! bacterial-type flagellum filament

[Term]
id: GO:0009422
name: bacterial-type flagellum hook-filament junction
namespace: cellular_component
def: "The region of the bacterial-type flagellum where the hook and filament meet." [GOC:cilia, GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar hook-filament junction" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009288 ! bacterial-type flagellum

[Term]
id: GO:0009423
name: chorismate biosynthetic process
namespace: biological_process
alt_id: GO:0033587
def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684]
synonym: "chorismate anabolism" EXACT []
synonym: "chorismate biosynthesis" EXACT []
synonym: "chorismate formation" EXACT []
synonym: "chorismate synthesis" EXACT []
synonym: "shikimate anabolism" RELATED []
synonym: "shikimate biosynthesis" RELATED []
synonym: "shikimate biosynthetic process" RELATED []
synonym: "shikimate pathway" EXACT []
synonym: "shikimate synthesis" RELATED []
xref: MetaCyc:ARO-PWY
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0009424
name: bacterial-type flagellum hook
namespace: cellular_component
def: "The portion of the bacterial-type flagellum that connects the filament to the basal body." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar hook" EXACT []
synonym: "flagellin-based flagellum hook" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009288 ! bacterial-type flagellum

[Term]
id: GO:0009425
name: bacterial-type flagellum basal body
namespace: cellular_component
def: "One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:24697492]
synonym: "flagellar basal body" BROAD []
synonym: "flagellin-based flagellum basal body" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009288 ! bacterial-type flagellum

[Term]
id: GO:0009426
name: bacterial-type flagellum basal body, distal rod
namespace: cellular_component
def: "The portion of the central rod of the bacterial-type flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
synonym: "flagellar basal body, distal rod" EXACT []
synonym: "flagellin-based flagellum basal body, distal rod" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod

[Term]
id: GO:0009427
name: bacterial-type flagellum basal body, distal rod, L ring
namespace: cellular_component
def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar basal body, distal rod, L ring" EXACT []
synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod

[Term]
id: GO:0009428
name: bacterial-type flagellum basal body, distal rod, P ring
namespace: cellular_component
def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar basal body, distal rod, P ring" RELATED []
synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod

[Term]
id: GO:0009429
name: bacterial-type flagellum basal body, proximal rod
namespace: cellular_component
def: "The portion of the central rod of the bacterial-type flagellar basal body that is proximal to the cell membrane; the proximal rod connects the distal rod to the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
synonym: "flagellar basal body, proximal rod" EXACT []
synonym: "flagellin-based flagellum basal body, proximal rod" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod

[Term]
id: GO:0009431
name: bacterial-type flagellum basal body, MS ring
namespace: cellular_component
alt_id: GO:0009430
def: "One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar basal body, mounting plate" BROAD []
synonym: "flagellar basal body, MS ring" EXACT []
synonym: "flagellin-based flagellum basal body, MS ring" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0009432
name: SOS response
namespace: biological_process
def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, PMID:16000023]
xref: Wikipedia:SOS_response
is_a: GO:0006974 ! DNA damage response

[Term]
id: GO:0009433
name: bacterial-type flagellum basal body, C ring
namespace: cellular_component
def: "Cytoplasmic ring located at the base of the bacterial-type flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
synonym: "flagellar basal body, C ring" EXACT []
synonym: "flagellin-based flagellum basal body, C ring" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0009435
name: NAD biosynthetic process
namespace: biological_process
alt_id: GO:0006736
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]
synonym: "NAD (oxidized) biosynthesis" EXACT []
synonym: "NAD (oxidized) biosynthetic process" EXACT []
synonym: "NAD (reduced) biosynthesis" EXACT []
synonym: "NAD (reduced) biosynthetic process" EXACT []
synonym: "NAD anabolism" EXACT []
synonym: "NAD biosynthesis" EXACT []
synonym: "NAD formation" EXACT []
synonym: "NAD synthesis" EXACT []
synonym: "NADH biosynthesis" EXACT []
synonym: "NADH biosynthetic process" EXACT []
synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT []
synonym: "oxidized NAD biosynthesis" EXACT []
synonym: "oxidized NAD biosynthetic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT []
synonym: "reduced NAD biosynthesis" EXACT []
synonym: "reduced NAD biosynthetic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0009436
name: glyoxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]
synonym: "glyoxylate breakdown" EXACT []
synonym: "glyoxylate catabolism" EXACT []
synonym: "glyoxylate degradation" EXACT []
xref: MetaCyc:GLYOXDEG-PWY
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046487 ! glyoxylate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0009437
name: carnitine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
synonym: "carnitine metabolism" EXACT []
synonym: "vitamin Bt metabolic process" EXACT []
synonym: "vitamin Bt metabolism" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process

[Term]
id: GO:0009438
name: methylglyoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai]
synonym: "methylglyoxal bypass" NARROW []
synonym: "methylglyoxal metabolism" EXACT []
synonym: "methylglyoxal pathway" NARROW []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0009439
name: cyanate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732]
synonym: "cyanate metabolism" EXACT []
xref: MetaCyc:CYANCAT-PWY
is_a: GO:0006082 ! organic acid metabolic process

[Term]
id: GO:0009440
name: cyanate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732]
synonym: "cyanate breakdown" EXACT []
synonym: "cyanate catabolism" EXACT []
synonym: "cyanate degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0009439 ! cyanate metabolic process

[Term]
id: GO:0009441
name: glycolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732]
synonym: "glycolate metabolism" EXACT []
xref: MetaCyc:GLYCOLATEMET-PWY
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0009442
name: allantoin assimilation pathway
namespace: biological_process
def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41]
synonym: "allantoin catabolic process via ureidoglycolate" EXACT []
synonym: "allantoin catabolism via ureidoglycolate" EXACT []
synonym: "allantoin degradation pathway" RELATED []
xref: MetaCyc:PWY0-41
is_a: GO:0000256 ! allantoin catabolic process

[Term]
id: GO:0009443
name: pyridoxal 5'-phosphate salvage
namespace: biological_process
def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl]
synonym: "pyridoxal 5' phosphate salvage" EXACT []
xref: MetaCyc:PLPSAL-PWY
is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0009444
name: obsolete pyruvate oxidation
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY]
comment: This term was obsoleted because it represents a molecular function.
xref: Wikipedia:Pyruvate_decarboxylation
is_obsolete: true

[Term]
id: GO:0009445
name: putrescine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai]
synonym: "putrescine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0009446
name: putrescine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732]
synonym: "putrescine anabolism" EXACT []
synonym: "putrescine biosynthesis" EXACT []
synonym: "putrescine formation" EXACT []
synonym: "putrescine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0009445 ! putrescine metabolic process

[Term]
id: GO:0009447
name: putrescine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai]
synonym: "putrescine breakdown" EXACT []
synonym: "putrescine catabolism" EXACT []
synonym: "putrescine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0009445 ! putrescine metabolic process

[Term]
id: GO:0009448
name: gamma-aminobutyric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]
comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'.
synonym: "4-aminobutanoate metabolic process" EXACT []
synonym: "4-aminobutanoate metabolism" EXACT []
synonym: "4-aminobutyrate metabolic process" EXACT []
synonym: "4-aminobutyrate metabolism" EXACT []
synonym: "GABA metabolic process" EXACT []
synonym: "GABA metabolism" EXACT []
synonym: "gamma-aminobutyric acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0009449
name: gamma-aminobutyric acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'.
synonym: "4-aminobutanoate biosynthesis" EXACT []
synonym: "4-aminobutanoate biosynthetic process" EXACT []
synonym: "4-aminobutyrate biosynthesis" EXACT []
synonym: "4-aminobutyrate biosynthetic process" EXACT []
synonym: "GABA biosynthesis" EXACT []
synonym: "GABA biosynthetic process" EXACT []
synonym: "gamma-aminobutyric acid anabolism" EXACT []
synonym: "gamma-aminobutyric acid biosynthesis" EXACT []
synonym: "gamma-aminobutyric acid formation" EXACT []
synonym: "gamma-aminobutyric acid synthesis" EXACT []
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0009450
name: gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'.
synonym: "4-aminobutanoate catabolic process" EXACT []
synonym: "4-aminobutanoate catabolism" EXACT []
synonym: "4-aminobutyrate catabolic process" EXACT []
synonym: "4-aminobutyrate catabolism" EXACT []
synonym: "GABA catabolic process" EXACT []
synonym: "GABA catabolism" EXACT []
synonym: "gamma-aminobutyric acid breakdown" EXACT []
synonym: "gamma-aminobutyric acid catabolism" EXACT []
synonym: "gamma-aminobutyric acid degradation" EXACT []
xref: MetaCyc:4AMINOBUTMETAB-PWY
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0009451
name: RNA modification
namespace: biological_process
alt_id: GO:0016547
def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing.
subset: goslim_yeast
synonym: "RNA editing" NARROW [GOC:hjd]
xref: Wikipedia:RNA_editing
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0009452
name: 7-methylguanosine RNA capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which the RNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:vw, PMID:9266685]
synonym: "m(7)G RNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah]
synonym: "RNA capping" BROAD [GOC:krc, GOC:mah]
is_a: GO:0036260 ! RNA capping

[Term]
id: GO:0009453
name: energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423]
synonym: "energytaxis" EXACT []
synonym: "taxis in response to energy source" EXACT []
is_a: GO:0042330 ! taxis

[Term]
id: GO:0009454
name: aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023]
synonym: "taxis in response to atmospheric oxygen" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0009455
name: redox taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423]
synonym: "redoxtaxis" EXACT []
synonym: "taxis in response to redox potential" EXACT []
synonym: "taxis in response to redox stimulus" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0009457
name: obsolete flavodoxin
namespace: molecular_function
def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "flavodoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009458
name: obsolete cytochrome
namespace: molecular_function
def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome" EXACT []
is_obsolete: true
consider: GO:0004129

[Term]
id: GO:0009459
name: obsolete cytochrome a
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome a" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009460
name: obsolete cytochrome b
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009461
name: obsolete cytochrome c
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0008121

[Term]
id: GO:0009462
name: obsolete cytochrome d
namespace: molecular_function
def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome d" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009463
name: obsolete cytochrome b/b6
namespace: molecular_function
def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b/b6" EXACT []
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0009464
name: obsolete cytochrome b5
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b5" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009465
name: obsolete soluble cytochrome b562
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "soluble cytochrome b562" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009466
name: obsolete class I cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class I cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009467
name: obsolete monoheme class I cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "monoheme class I cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009468
name: obsolete diheme class I cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "diheme class I cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009469
name: obsolete class II cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class II cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009470
name: obsolete class IIa cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class IIa cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009471
name: obsolete class III cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class III cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009472
name: obsolete cytochrome c3 (tetraheme)
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c3 (tetraheme)" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009473
name: obsolete cytochrome c7 (triheme)
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c7 (triheme)" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009474
name: obsolete nonaheme cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "nonaheme cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009475
name: obsolete high-molecular-weight cytochrome c (hexadecaheme)
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "high-molecular-weight cytochrome c (hexadecaheme)" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009476
name: obsolete class IV cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class IV cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009477
name: obsolete cytochrome c1
namespace: molecular_function
def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c1" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009478
name: obsolete cytochrome c554
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c554" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009479
name: obsolete cytochrome f
namespace: molecular_function
def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome f" EXACT []
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0009480
name: obsolete class IIb cytochrome c
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class IIb cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009481
name: obsolete aa3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "aa3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009482
name: obsolete ba3-type cytochrome c oxidase
namespace: molecular_function
alt_id: GO:0009484
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "ba3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009483
name: obsolete caa3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "caa3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009485
name: obsolete cbb3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "cbb3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009486
name: cytochrome bo3 ubiquinol oxidase activity
namespace: molecular_function
alt_id: GO:0008827
def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]." [RHEA:30251]
synonym: "cytochrome bo oxidase" EXACT [EC:7.1.1.3]
synonym: "cytochrome bo(3) oxidase" EXACT [EC:7.1.1.3]
synonym: "cytochrome o ubiquinol oxidase activity" RELATED []
xref: EC:7.1.1.3
xref: MetaCyc:RXN0-5268
xref: RHEA:30251
xref: TC:3.D.4.5.1
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors

[Term]
id: GO:0009487
name: obsolete glutaredoxin
namespace: molecular_function
def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
synonym: "glutaredoxin" EXACT []
is_obsolete: true
consider: GO:0003756
consider: GO:0015036
consider: GO:0015038

[Term]
id: GO:0009488
name: obsolete amicyanin
namespace: molecular_function
def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "amicyanin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009489
name: obsolete rubredoxin
namespace: molecular_function
def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "rubredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009490
name: obsolete mononuclear iron electron carrier
namespace: molecular_function
def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "mononuclear iron electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009491
name: obsolete redox-active disulfide bond electron carrier
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "redox-active disulfide bond electron carrier" EXACT []
synonym: "redox-active disulphide bond electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009492
name: obsolete 2Fe-2S electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "2Fe-2S electron transfer carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009493
name: obsolete adrenodoxin-type ferredoxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "adrenodoxin-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009494
name: obsolete chloroplast-type ferredoxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "chloroplast-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009495
name: obsolete thioredoxin-like 2Fe-2S ferredoxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "thioredoxin-like 2Fe-2S ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009496
name: plastoquinol--plastocyanin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H+[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane." [RHEA:22148]
synonym: "cytochrome b6f" NARROW []
synonym: "cytochrome b6f complex activity" RELATED [EC:7.1.1.6]
synonym: "plastoquinol-plastocyanin reductase activity" RELATED []
synonym: "plastoquinol/plastocyanin oxidoreductase activity" RELATED []
synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" RELATED []
xref: EC:7.1.1.6
xref: KEGG_REACTION:R03817
xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN
xref: RHEA:22148
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity
is_a: GO:0052880 ! oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor

[Term]
id: GO:0009497
name: obsolete 3Fe-4S/4Fe-4S electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "3Fe-4S/4Fe-4S electron transfer carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009498
name: obsolete bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "bacterial-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009499
name: obsolete monocluster bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "monocluster bacterial-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009500
name: obsolete dicluster bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "dicluster bacterial-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009501
name: amyloplast
namespace: cellular_component
def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031]
xref: Wikipedia:Amyloplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009502
name: obsolete photosynthetic electron transport chain
namespace: cellular_component
def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:0140514031]
comment: This term was made obsolete because it represents a process.
synonym: "photosynthetic electron transport chain" EXACT []
is_obsolete: true
consider: GO:0009767

[Term]
id: GO:0009503
name: thylakoid light-harvesting complex
namespace: cellular_component
def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684]
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex

[Term]
id: GO:0009504
name: cell plate
namespace: cellular_component
def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equatorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684]
xref: Wikipedia:Cell_plate
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009505
name: plant-type cell wall
namespace: cellular_component
def: "A more or less rigid structure lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208]
synonym: "cellulose and pectin-containing cell wall" EXACT []
synonym: "plant cell wall" NARROW []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009506
name: plasmodesma
namespace: cellular_component
def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:29880547]
synonym: "plasmodesmata" EXACT []
xref: Wikipedia:Plasmodesma
is_a: GO:0005911 ! cell-cell junction
relationship: part_of GO:0055044 ! symplast

[Term]
id: GO:0009507
name: chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208]
subset: goslim_plant
subset: goslim_plant_ribbon
xref: Wikipedia:Chloroplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009508
name: plastid chromosome
namespace: cellular_component
def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943088399]
is_a: GO:0005694 ! chromosome
relationship: part_of GO:0042646 ! plastid nucleoid

[Term]
id: GO:0009509
name: chromoplast
namespace: cellular_component
def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208]
xref: Wikipedia:Chromoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009510
name: plasmodesmatal desmotubule
namespace: cellular_component
alt_id: GO:0009572
def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [PMID:29880547]
synonym: "desmotubule central rod" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009511
name: plasmodesmatal endoplasmic reticulum
namespace: cellular_component
def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai, PMID:29880547]
synonym: "plasmodesmatal ER" EXACT []
is_a: GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0009510 ! plasmodesmatal desmotubule

[Term]
id: GO:0009512
name: cytochrome b6f complex
namespace: cellular_component
def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943088399, PMID:16228398, PMID:16352458]
synonym: "cyt b(6)f complex" EXACT []
synonym: "cyt b6-f complex" EXACT []
synonym: "cyt b6/f complex" EXACT []
synonym: "cyt b6f complex" EXACT []
synonym: "cytochrome b(6)f complex" EXACT []
synonym: "cytochrome b6-f complex" EXACT []
synonym: "cytochrome b6/f complex" EXACT []
xref: Wikipedia:Cytochrome_b6f_complex
is_a: GO:0070069 ! cytochrome complex
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0009513
name: etioplast
namespace: cellular_component
def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943088399]
xref: Wikipedia:Etioplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009514
name: glyoxysome
namespace: cellular_component
def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031]
xref: Wikipedia:Glyoxysome
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0009515
name: granal stacked thylakoid
namespace: cellular_component
def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr]
synonym: "chloroplast stacked thylakoid" EXACT []
is_a: GO:0009534 ! chloroplast thylakoid
relationship: part_of GO:0009542 ! granum

[Term]
id: GO:0009516
name: leucoplast
namespace: cellular_component
def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943088399]
xref: Wikipedia:Leucoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009517
name: PSII associated light-harvesting complex II
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089]
synonym: "LHCII" EXACT []
is_a: GO:0009503 ! thylakoid light-harvesting complex

[Term]
id: GO:0009518
name: PSI associated light-harvesting complex I
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem I." [GOC:lr]
synonym: "LHCI" EXACT []
is_a: GO:0009503 ! thylakoid light-harvesting complex

[Term]
id: GO:0009519
name: middle lamella
namespace: cellular_component
def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208]
xref: Wikipedia:Middle_lamella
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0009521
name: photosystem
namespace: cellular_component
alt_id: GO:0030090
def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]
subset: goslim_pir
synonym: "reaction center" NARROW []
synonym: "reaction centre" NARROW []
xref: Wikipedia:Photosystem
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0034357 ! photosynthetic membrane

[Term]
id: GO:0009522
name: photosystem I
namespace: cellular_component
def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]
is_a: GO:0009521 ! photosystem

[Term]
id: GO:0009523
name: photosystem II
namespace: cellular_component
def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949]
xref: Wikipedia:Photosystem_II
is_a: GO:0009521 ! photosystem

[Term]
id: GO:0009524
name: phragmoplast
namespace: cellular_component
def: "The phragmoplast is a plant cell specific cytoplasmic structure composed of cytoskeletal polymers, membranes, and associated cytosolic proteins that functions as the focused secretory module for assembling the cell plate." [PMID:28943203]
xref: Wikipedia:Phragmoplast
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009525
name: phragmosome
namespace: cellular_component
def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943088399]
xref: Wikipedia:Phragmosome
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009526
name: plastid envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy]
is_a: GO:0031967 ! organelle envelope
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0009527
name: plastid outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr]
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009528
name: plastid inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr]
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009529
name: plastid intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr]
synonym: "plastid envelope lumen" EXACT []
is_a: GO:0031970 ! organelle envelope lumen
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0009530
name: primary cell wall
namespace: cellular_component
def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jid, PMID:9442872]
is_a: GO:0009505 ! plant-type cell wall

[Term]
id: GO:0009531
name: secondary cell wall
namespace: cellular_component
def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jid, ISBN:0943088399]
xref: Wikipedia:Secondary_cell_wall
is_a: GO:0009505 ! plant-type cell wall

[Term]
id: GO:0009532
name: plastid stroma
namespace: cellular_component
def: "The proteinaceous ground substance of plastids." [ISBN:0943088399]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0009533
name: chloroplast stromal thylakoid
namespace: cellular_component
def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943088399]
is_a: GO:0009534 ! chloroplast thylakoid
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009534
name: chloroplast thylakoid
namespace: cellular_component
def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943088399]
is_a: GO:0031976 ! plastid thylakoid
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0009535
name: chloroplast thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0009534 ! chloroplast thylakoid

[Term]
id: GO:0009536
name: plastid
namespace: cellular_component
def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
xref: Wikipedia:Plastid
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0009537
name: proplastid
namespace: cellular_component
def: "The precursor of other plastids." [ISBN:0943088399]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009538
name: photosystem I reaction center
namespace: cellular_component
def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399]
synonym: "photosystem I reaction centre" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009539
name: photosystem II reaction center
namespace: cellular_component
def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399]
synonym: "photosystem II reaction centre" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009541
name: etioplast prolamellar body
namespace: cellular_component
def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009542
name: granum
namespace: cellular_component
def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:0140514031]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0009543
name: chloroplast thylakoid lumen
namespace: cellular_component
def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943088399]
is_a: GO:0031978 ! plastid thylakoid lumen
relationship: part_of GO:0009534 ! chloroplast thylakoid

[Term]
id: GO:0009544
name: obsolete chloroplast ATP synthase complex
namespace: cellular_component
def: "OBSOLETE. The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045259

[Term]
id: GO:0009545
name: elaioplast
namespace: cellular_component
def: "A leucoplast in which oil is stored." [ISBN:0140514031]
xref: Wikipedia:Elaioplast
is_a: GO:0009516 ! leucoplast

[Term]
id: GO:0009546
name: plasmodesmatal cytoplasmic sleeve
namespace: cellular_component
def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [PMID:29880547]
synonym: "plasmodesmatal cytoplasmic annulus" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009547
name: plastid ribosome
namespace: cellular_component
def: "A ribosome contained within a plastid." [GOC:tair_curators]
is_a: GO:0000313 ! organellar ribosome
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0009548
name: plasmodesmatal plasma membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009549
name: cellulose microfibril
namespace: cellular_component
def: "A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jid, ISBN:0943088399]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009505 ! plant-type cell wall

[Term]
id: GO:0009550
name: primary plasmodesma
namespace: cellular_component
def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255]
synonym: "simple plasmodesma" EXACT []
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009551
name: secondary plasmodesma
namespace: cellular_component
def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255]
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009553
name: embryo sac development
namespace: biological_process
alt_id: GO:0048230
def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb]
synonym: "female gametophyte development" EXACT []
is_a: GO:0048229 ! gametophyte development

[Term]
id: GO:0009554
name: megasporogenesis
namespace: biological_process
def: "The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb]
synonym: "megaspore development" EXACT []
synonym: "megaspore mother cell meiosis" EXACT []
synonym: "meiosis of the megasporocyte" EXACT []
synonym: "meiotic division of the megasporocyte" EXACT []
is_a: GO:0048236 ! plant-type sporogenesis
relationship: part_of GO:0009553 ! embryo sac development

[Term]
id: GO:0009555
name: pollen development
namespace: biological_process
alt_id: GO:0009564
alt_id: GO:0048231
def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb]
synonym: "formation of generative and vegetative cells" EXACT []
synonym: "male gametophyte development" EXACT []
synonym: "male gametophyte formation" EXACT []
synonym: "microgametophyte development" EXACT []
synonym: "pollen grain formation" EXACT []
is_a: GO:0048229 ! gametophyte development

[Term]
id: GO:0009556
name: microsporogenesis
namespace: biological_process
def: "The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb]
synonym: "microspore development" EXACT systematic_synonym []
is_a: GO:0048236 ! plant-type sporogenesis
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0009557
name: antipodal cell differentiation
namespace: biological_process
def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jid, GOC:mtg_plant]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009558
name: embryo sac cellularization
namespace: biological_process
alt_id: GO:0009797
def: "The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X]
synonym: "cellularization of the embryo sac" EXACT []
synonym: "female gametophyte cellularization" EXACT []
synonym: "megagametophyte cellularization" EXACT []
is_a: GO:0007349 ! cellularization
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009559
name: embryo sac central cell differentiation
namespace: biological_process
def: "The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jid, GOC:mtg_plant]
synonym: "embryo sac endosperm mother cell differentiation" EXACT []
synonym: "female gametophyte central cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009560
name: embryo sac egg cell differentiation
namespace: biological_process
alt_id: GO:0048233
def: "The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu]
synonym: "female gamete generation" BROAD []
synonym: "female gametophyte egg cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007292 ! female gamete generation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009561
name: megagametogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant]
synonym: "embryo sac development from the megaspore" EXACT systematic_synonym []
synonym: "megagametophyte nucleus division" EXACT []
xref: Wikipedia:Megagametogenesis
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0009553 ! embryo sac development

[Term]
id: GO:0009562
name: embryo sac nuclear migration
namespace: biological_process
def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant]
synonym: "embryo sac nucleus migration" EXACT []
synonym: "female gametophyte nuclear migration" EXACT []
synonym: "female gametophyte nucleus migration" EXACT []
synonym: "megagametophyte nuclear migration" EXACT []
synonym: "megagametophyte nucleus migration" EXACT []
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009563
name: synergid differentiation
namespace: biological_process
def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jid]
synonym: "synergid cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009566
name: fertilization
namespace: biological_process
def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]
synonym: "syngamy" EXACT []
xref: Wikipedia:Fertilisation
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0009567
name: double fertilization forming a zygote and endosperm
namespace: biological_process
def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "double fertilization" EXACT []
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0009568
name: amyloplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
synonym: "amyloplast starch granule" EXACT []
is_a: GO:0043036 ! starch grain
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0009569
name: chloroplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732]
synonym: "chloroplast starch granule" EXACT []
is_a: GO:0043036 ! starch grain
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0009570
name: chloroplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0009571
name: proplastid stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a proplastid." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009537 ! proplastid

[Term]
id: GO:0009573
name: chloroplast ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu]
synonym: "chloroplast RubisCO complex" EXACT []
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009574
name: preprophase band
namespace: cellular_component
def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732]
xref: Wikipedia:Preprophase_band
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0009575
name: chromoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009509 ! chromoplast

[Term]
id: GO:0009576
name: leucoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009516 ! leucoplast

[Term]
id: GO:0009577
name: elaioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009545 ! elaioplast

[Term]
id: GO:0009578
name: etioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009579
name: thylakoid
namespace: cellular_component
def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732]
comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "photosynthetic membrane" RELATED []
xref: Wikipedia:Thylakoid
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0009580
name: obsolete thylakoid (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific children exist.
synonym: "thylakoid (sensu Bacteria)" EXACT []
is_obsolete: true
consider: GO:0030075
consider: GO:0042716

[Term]
id: GO:0009581
name: detection of external stimulus
namespace: biological_process
def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
synonym: "perception of external stimulus" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009582
name: detection of abiotic stimulus
namespace: biological_process
def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
synonym: "perception of abiotic stimulus" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009583
name: detection of light stimulus
namespace: biological_process
def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators]
synonym: "detection of light" EXACT []
synonym: "perception of light" RELATED []
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0009584
name: detection of visible light
namespace: biological_process
def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
synonym: "perception of visible light" RELATED []
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009585
name: red, far-red light phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah]
synonym: "phytochrome signaling pathway" BROAD []
synonym: "red-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction
relationship: part_of GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0009587
name: obsolete phototrophin mediated phototransduction
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
synonym: "phototrophin mediated phototransduction" EXACT []
is_obsolete: true
replaced_by: GO:0007602

[Term]
id: GO:0009588
name: UV-A, blue light phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah]
synonym: "blue-sensitive opsin" RELATED []
synonym: "short-wave-sensitive opsin" RELATED []
synonym: "violet-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction

[Term]
id: GO:0009589
name: detection of UV
namespace: biological_process
def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732]
synonym: "detection of ultraviolet light stimulus" EXACT []
synonym: "detection of ultraviolet radiation stimulus" EXACT []
synonym: "detection of UV light stimulus" EXACT []
synonym: "detection of UV radiation stimulus" EXACT []
synonym: "perception of UV" RELATED []
is_a: GO:0009411 ! response to UV
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009590
name: detection of gravity
namespace: biological_process
def: "The series of events in which a gravitational stimulus is received and converted into a molecular signal." [GOC:dos, GOC:hb]
synonym: "perception of gravity" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009629 ! response to gravity

[Term]
id: GO:0009591
name: obsolete perception of mechanical stimulus
namespace: biological_process
alt_id: GO:0007609
def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage.
synonym: "perception of mechanical stimulus" EXACT []
is_obsolete: true
consider: GO:0050954

[Term]
id: GO:0009593
name: detection of chemical stimulus
namespace: biological_process
def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "chemoperception" EXACT []
synonym: "chemoreception" RELATED []
synonym: "detection of chemical substance" EXACT []
synonym: "perception of chemical stimulus" RELATED []
synonym: "perception of chemical substance" RELATED []
is_a: GO:0051606 ! detection of stimulus
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0009594
name: detection of nutrient
namespace: biological_process
def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "detection of nutrients" EXACT []
synonym: "nutrient sensing" RELATED []
synonym: "perception of nutrients" RELATED []
is_a: GO:0007584 ! response to nutrient
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0009595
name: detection of biotic stimulus
namespace: biological_process
alt_id: GO:0009596
def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb]
synonym: "perception of biotic stimulus" RELATED []
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009597
name: detection of virus
namespace: biological_process
def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb]
comment: GO:0009597 is not a child term of 'detection of symbiont ; GO:0009602' to allow annotation of a virus responding to another (often competing) virus.
synonym: "perception of virus" RELATED []
is_a: GO:0009615 ! response to virus

[Term]
id: GO:0009600
name: detection of nematode
namespace: biological_process
def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb]
synonym: "perception of nematode" RELATED []
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0009601
name: detection of insect
namespace: biological_process
def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb]
synonym: "perception of insect" RELATED []
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0009602
name: detection of symbiont
namespace: biological_process
alt_id: GO:0051855
def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732]
synonym: "perception of symbiont" RELATED []
synonym: "recognition of symbiont" EXACT []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0051702 ! biological process involved in interaction with symbiont
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0009603
name: detection of symbiotic fungus
namespace: biological_process
def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732]
synonym: "detection of symbiotic fungi" EXACT []
synonym: "perception of symbiotic fungi" RELATED []
synonym: "perception of symbiotic fungus" RELATED []
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0009610 ! response to symbiotic fungus
is_a: GO:0016046 ! detection of fungus

[Term]
id: GO:0009604
name: detection of symbiotic bacterium
namespace: biological_process
def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732]
synonym: "detection of symbiotic bacteria" EXACT []
synonym: "perception of symbiotic bacteria" RELATED []
synonym: "perception of symbiotic bacterium" RELATED []
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0009609 ! response to symbiotic bacterium
is_a: GO:0016045 ! detection of bacterium

[Term]
id: GO:0009605
name: response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_drosophila
subset: goslim_plant
synonym: "response to environmental stimulus" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009606
name: tropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:curators, ISBN:0877795088]
subset: goslim_plant
xref: Wikipedia:Tropism
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0009607
name: response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to biotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009608
name: response to symbiont
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732]
synonym: "response of host to symbiont" RELATED []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009609
name: response to symbiotic bacterium
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732]
synonym: "response to symbiotic bacteria" EXACT []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0009617 ! response to bacterium

[Term]
id: GO:0009610
name: response to symbiotic fungus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732]
synonym: "response to symbiotic fungi" EXACT []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0009611
name: response to wounding
namespace: biological_process
alt_id: GO:0002245
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
synonym: "physiological response to wounding" EXACT []
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0009612
name: response to mechanical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanical stimulus response" EXACT []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009614
name: obsolete disease resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "disease resistance" EXACT []
is_obsolete: true
replaced_by: GO:0051707

[Term]
id: GO:0009615
name: response to virus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb]
synonym: "response to viruses" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009616
name: RNAi-mediated antiviral immune response
namespace: biological_process
alt_id: GO:0060145
alt_id: GO:0060150
def: "A post-transcriptional gene silencing pathway mediated by the action of regulatory RNAs that protects against foreign organism invasion by restricting viral replication and dissemination." [GOC:jl, PMID:17693253, PMID:21724934, PMID:23686236, PMID:24732439, PMID:31100912]
comment: Virus induced gene silencing (VIGS) is used as a technique to control plant gene expression; when used in that context, this does not represent a normal biological process and is outside the scope of GO.
synonym: "RNAi-mediated antiviral immunity" EXACT []
synonym: "VIGS" RELATED []
synonym: "viral gene silencing in virus induced gene silencing" RELATED []
synonym: "viral triggering of virus induced gene silencing" RELATED []
synonym: "virus induced gene silencing" EXACT []
synonym: "virus-induced gene silencing" EXACT []
synonym: "virus-induced PTGS" EXACT []
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing
is_a: GO:0045087 ! innate immune response
is_a: GO:0051607 ! defense response to virus

[Term]
id: GO:0009617
name: response to bacterium
namespace: biological_process
alt_id: GO:0009618
alt_id: GO:0009680
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
synonym: "response to bacteria" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009619
name: obsolete resistance to pathogenic bacteria
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "resistance to pathogenic bacteria" EXACT []
is_obsolete: true
replaced_by: GO:0009617

[Term]
id: GO:0009620
name: response to fungus
namespace: biological_process
alt_id: GO:0009621
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
synonym: "response to fungi" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009622
name: obsolete resistance to pathogenic fungi
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "resistance to pathogenic fungi" EXACT []
is_obsolete: true
replaced_by: GO:0009620

[Term]
id: GO:0009624
name: response to nematode
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb]
synonym: "response to nematodes" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009625
name: response to insect
namespace: biological_process
alt_id: GO:0043019
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb]
synonym: "response to insects" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009626
name: plant-type hypersensitive response
namespace: biological_process
def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089]
comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider using 'effector-mediated activation of plant hypersensitive response by symbiont' ; GO:0080185.
synonym: "HR" BROAD []
synonym: "HR-PCD" EXACT []
synonym: "plant hypersensitive response" EXACT []
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034050 ! symbiont-induced defense-related programmed cell death
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0009627
name: systemic acquired resistance
namespace: biological_process
def: "The salicylic acid-mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, Wikipedia:Systemic_acquired_resistance]
synonym: "salicylic acid-dependent systemic resistance" EXACT []
xref: Wikipedia:Systemic_acquired_resistance
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0009628
name: response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to abiotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009629
name: response to gravity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb]
synonym: "response to gravitational stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009630
name: gravitropism
namespace: biological_process
def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684]
synonym: "geotropism" EXACT []
xref: Wikipedia:Gravitropism
is_a: GO:0009606 ! tropism
is_a: GO:0009629 ! response to gravity

[Term]
id: GO:0009631
name: cold acclimation
namespace: biological_process
def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0009632
name: obsolete freezing tolerance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process.
synonym: "freezing tolerance" EXACT []
is_obsolete: true
consider: GO:0009409

[Term]
id: GO:0009633
name: obsolete drought tolerance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process.
synonym: "drought tolerance" EXACT []
is_obsolete: true
consider: GO:0009414
consider: GO:0009819

[Term]
id: GO:0009634
name: obsolete heavy metal sensitivity/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "heavy metal sensitivity/resistance" EXACT []
is_obsolete: true
consider: GO:0010038

[Term]
id: GO:0009635
name: response to herbicide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [GOC:curators]
synonym: "herbicide susceptibility/resistance" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0009636
name: response to toxic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]
subset: goslim_chembl
synonym: "detoxification response" NARROW []
synonym: "toxin resistance" RELATED []
synonym: "toxin susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0009637
name: response to blue light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red]
synonym: "blue light response" EXACT []
synonym: "blue-light response" EXACT []
synonym: "response to blue light stimulus" EXACT []
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009638
name: phototropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, PMID:16870491]
xref: Wikipedia:Phototropism
is_a: GO:0009606 ! tropism
is_a: GO:0009637 ! response to blue light

[Term]
id: GO:0009639
name: response to red or far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009640
name: photomorphogenesis
namespace: biological_process
def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr]
synonym: "plant development in response to light" EXACT systematic_synonym []
xref: Wikipedia:Photomorphogenesis
is_a: GO:0009639 ! response to red or far red light
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0009641
name: shade avoidance
namespace: biological_process
def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance]
xref: Wikipedia:Shade_avoidance
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0009642
name: response to light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009643
name: photosynthetic acclimation
namespace: biological_process
def: "A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light." [GOC:mah, PMID:11069694]
synonym: "light acclimatization" EXACT [PMID:11069694]
synonym: "photoacclimation" EXACT [GOC:tb]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009644
name: response to high light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009645
name: response to low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009646
name: response to absence of light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators]
synonym: "response to darkness" RELATED []
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009647
name: skotomorphogenesis
namespace: biological_process
def: "The control of plant growth, development, and differentiation in response to growth in darkness." [PMID:15012288]
synonym: "etiolation" RELATED []
is_a: GO:0009646 ! response to absence of light
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0009648
name: photoperiodism
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "response to day length" EXACT []
synonym: "response to night length" EXACT []
synonym: "response to photoperiod" EXACT []
xref: Wikipedia:Photoperiodism
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009649
name: entrainment of circadian clock
namespace: biological_process
def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
synonym: "regulation of circadian rhythm phase" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0042752 ! regulation of circadian rhythm

[Term]
id: GO:0009650
name: UV protection
namespace: biological_process
def: "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]
synonym: "ultraviolet protection" EXACT []
synonym: "ultraviolet resistance" RELATED []
synonym: "ultraviolet tolerance" RELATED []
synonym: "UV resistance" RELATED []
synonym: "UV tolerance" RELATED []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0009651
name: response to salt stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
synonym: "response to ionic osmotic stress" EXACT []
synonym: "salinity response" EXACT []
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0009652
name: thigmotropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, PMID:16153165]
xref: Wikipedia:Thigmotropism
is_a: GO:0009606 ! tropism
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0009653
name: anatomical structure morphogenesis
namespace: biological_process
def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
synonym: "anatomical structure organization" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "morphogenesis" EXACT []
xref: Wikipedia:Morphogenesis
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0009654
name: photosystem II oxygen evolving complex
namespace: cellular_component
def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [GOC:cjm, InterPro:IPR002683]
synonym: "OEC (PSII) complex" EXACT [GOC:cjm]
synonym: "oxygen evolving complex" EXACT [GOC:cjm]
xref: Wikipedia:Oxygen_evolving_complex
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0009523 ! photosystem II
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0009655
name: PSII associated light-harvesting complex II, core complex
namespace: cellular_component
def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr]
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW []
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW []
synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW []
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009656
name: PSII associated light-harvesting complex II, peripheral complex
namespace: cellular_component
def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr]
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009657
name: plastid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah]
subset: goslim_pir
synonym: "plastid organisation" EXACT []
synonym: "plastid organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0009658
name: chloroplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid]
synonym: "chloroplast organisation" EXACT []
synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009659
name: leucoplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jid]
synonym: "leucoplast organisation" EXACT []
synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009660
name: amyloplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jid]
synonym: "amyloplast organisation" EXACT []
synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009661
name: chromoplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jid]
synonym: "chromoplast organisation" EXACT []
synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009662
name: etioplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jid]
synonym: "etioplast organisation" EXACT []
synonym: "etioplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009663
name: plasmodesma organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah, PMID:29880547]
synonym: "plasmodesma organisation" EXACT []
synonym: "plasmodesma organization and biogenesis" RELATED []
synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0009664
name: plant-type cell wall organization
namespace: biological_process
def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu]
synonym: "cell wall organization and biogenesis" NARROW []
synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "plant-type cell wall organisation" EXACT []
synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071555 ! cell wall organization
is_a: GO:0071669 ! plant-type cell wall organization or biogenesis

[Term]
id: GO:0009665
name: plastid inheritance
namespace: biological_process
def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah]
is_a: GO:0009657 ! plastid organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0009666
name: plastid outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid outer membrane organisation" EXACT []
synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0009667
name: plastid inner membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid inner membrane organisation" EXACT []
synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0009668
name: plastid membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid membrane organisation" EXACT []
synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0009657 ! plastid organization

[Term]
id: GO:0009669
name: sucrose:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1]
synonym: "sucrose permease activity" RELATED []
synonym: "sucrose:cation symporter activity" BROAD []
synonym: "sucrose:monovalent cation symporter activity" EXACT []
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0008515 ! sucrose transmembrane transporter activity

[Term]
id: GO:0009670
name: triose-phosphate:phosphate antiporter activity
namespace: molecular_function
alt_id: GO:0015122
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)." [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-]
synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT []
synonym: "TPT" RELATED []
synonym: "triose phosphate antiporter" EXACT []
synonym: "triose phosphate translocator" EXACT []
is_a: GO:0015315 ! organophosphate:phosphate antiporter activity
is_a: GO:0071917 ! triose-phosphate transmembrane transporter activity

[Term]
id: GO:0009671
name: nitrate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981]
synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT []
synonym: "nitrate(chlorate):proton symporter activity" EXACT []
synonym: "nitrate:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity

[Term]
id: GO:0009672
name: auxin:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077]
synonym: "auxin:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0080161 ! auxin transmembrane transporter activity

[Term]
id: GO:0009673
name: low-affinity phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-]
synonym: "low affinity phosphate transmembrane transporter activity" EXACT []
is_a: GO:0005315 ! phosphate transmembrane transporter activity

[Term]
id: GO:0009674
name: potassium:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1]
synonym: "high affinity potassium transporter" RELATED []
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0009675
name: high-affinity sulfate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity sulfate:hydrogen symporter activity" EXACT []
synonym: "high affinity sulfate:proton symporter activity" EXACT []
synonym: "high affinity sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008512 ! sulfate:proton symporter activity

[Term]
id: GO:0009676
name: low-affinity sulfate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135]
synonym: "low affinity sulfate:hydrogen symporter activity" EXACT []
synonym: "low affinity sulfate:proton symporter activity" EXACT []
synonym: "low affinity sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008512 ! sulfate:proton symporter activity

[Term]
id: GO:0009677
name: double fertilization forming two zygotes
namespace: biological_process
def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb]
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0009678
name: diphosphate hydrolysis-driven proton transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate." [GOC:mtg_transport, Wikipedia:Proton-pumping_pyrophosphatase]
synonym: "H+-exporting diphosphatase" RELATED [EC:7.1.3.1]
synonym: "hydrogen-translocating pyrophosphatase activity" RELATED [EC:7.1.3.1]
synonym: "PP(i) hydrolysis-driven proton transmembrane transporter activity" EXACT []
synonym: "proton-pumping diphosphatase" RELATED [EC:7.1.3.1]
synonym: "proton-pumping pyrophosphatase" RELATED [EC:7.1.3.1]
synonym: "proton-translocating pyrophosphatase activity" EXACT []
synonym: "pyrophosphate hydrolysis-driven proton transmembrane transporter activity" RELATED []
xref: EC:7.1.3.1
xref: MetaCyc:TRANS-RXN-370
xref: RHEA:13973
xref: TC:3.A.10
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015399 ! primary active transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0009679
name: hexose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-]
synonym: "hexose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0009682
name: induced systemic resistance
namespace: biological_process
def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273, PMID:15233292, PMID:23386685]
is_a: GO:0042742 ! defense response to bacterium
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0009683
name: indoleacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah]
synonym: "IAA metabolic process" EXACT []
synonym: "indole acetic acid metabolic process" EXACT []
synonym: "indole acetic acid metabolism" EXACT []
synonym: "indoleacetic acid metabolism" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0009684
name: indoleacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845]
synonym: "IAA biosynthetic process" EXACT []
synonym: "indole acetic acid biosynthesis" EXACT []
synonym: "indole acetic acid biosynthetic process" EXACT []
synonym: "indole-3-acetate biosynthesis" EXACT []
synonym: "indole-3-acetate biosynthetic process" EXACT []
synonym: "indole-acetic acid biosynthesis" EXACT []
synonym: "indole-acetic acid biosynthetic process" RELATED []
synonym: "indoleacetic acid anabolism" EXACT []
synonym: "indoleacetic acid biosynthesis" EXACT []
synonym: "indoleacetic acid formation" EXACT []
synonym: "indoleacetic acid synthesis" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process
is_a: GO:0009851 ! auxin biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009685
name: gibberellin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845]
synonym: "gibberellic acid metabolic process" NARROW []
synonym: "gibberellic acid metabolism" NARROW []
synonym: "gibberellin metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0009686
name: gibberellin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845]
synonym: "gibberellic acid anabolism" NARROW []
synonym: "gibberellic acid biosynthesis" NARROW []
synonym: "gibberellic acid biosynthetic process" NARROW []
synonym: "gibberellic acid formation" NARROW []
synonym: "gibberellic acid synthesis" NARROW []
synonym: "gibberellin biosynthesis" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009687
name: abscisic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845]
synonym: "abscisic acid metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043288 ! apocarotenoid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0009688
name: abscisic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845]
synonym: "abscisic acid anabolism" EXACT []
synonym: "abscisic acid biosynthesis" EXACT []
synonym: "abscisic acid formation" EXACT []
synonym: "abscisic acid synthesis" EXACT []
xref: MetaCyc:PWY-695
is_a: GO:0009687 ! abscisic acid metabolic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0043289 ! apocarotenoid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0009689
name: obsolete induction of phytoalexin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399]
comment: This term was obsoleted because it represents the same process as positive regulation of phytoalexin biosynthetic process ; GO:0052322.
synonym: "induction of phytoalexin anabolism" EXACT []
synonym: "induction of phytoalexin biosynthesis" EXACT []
synonym: "induction of phytoalexin formation" EXACT []
synonym: "induction of phytoalexin synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0052322

[Term]
id: GO:0009690
name: cytokinin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845]
subset: goslim_chembl
synonym: "cytokinin metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0009691
name: cytokinin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845]
synonym: "cytokinin anabolism" EXACT []
synonym: "cytokinin biosynthesis" EXACT []
synonym: "cytokinin formation" EXACT []
synonym: "cytokinin synthesis" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0009692
name: ethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845]
synonym: "ethene metabolic process" EXACT []
synonym: "ethene metabolism" EXACT []
synonym: "ethylene metabolism" EXACT []
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:0009693
name: ethylene biosynthetic process
namespace: biological_process
alt_id: GO:0042456
def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845]
synonym: "ethene biosynthesis" EXACT []
synonym: "ethene biosynthesis from L-methionine" EXACT []
synonym: "ethene biosynthetic process" EXACT []
synonym: "ethene biosynthetic process from L-methionine" EXACT []
synonym: "ethylene anabolism" EXACT []
synonym: "ethylene biosynthesis" EXACT []
synonym: "ethylene biosynthesis from L-methionine" EXACT []
synonym: "ethylene biosynthetic process from L-methionine" EXACT []
synonym: "ethylene formation" EXACT []
synonym: "ethylene synthesis" EXACT []
xref: MetaCyc:ETHYL-PWY
is_a: GO:0009692 ! ethylene metabolic process
is_a: GO:0043450 ! alkene biosynthetic process

[Term]
id: GO:0009694
name: jasmonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845]
synonym: "jasmonic acid metabolism" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process

[Term]
id: GO:0009695
name: jasmonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [PMID:33821356]
synonym: "jasmonic acid anabolism" EXACT []
synonym: "jasmonic acid biosynthesis" EXACT []
synonym: "jasmonic acid formation" EXACT []
synonym: "jasmonic acid synthesis" EXACT []
xref: MetaCyc:PWY-735
is_a: GO:0009694 ! jasmonic acid metabolic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process

[Term]
id: GO:0009696
name: salicylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399]
synonym: "salicylic acid metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0009697
name: salicylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399]
synonym: "salicylate biosynthetic process" EXACT []
synonym: "salicylic acid anabolism" EXACT []
synonym: "salicylic acid biosynthesis" EXACT []
synonym: "salicylic acid formation" EXACT []
synonym: "salicylic acid synthesis" EXACT []
xref: MetaCyc:PWY-981
is_a: GO:0009696 ! salicylic acid metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009698
name: phenylpropanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl]
synonym: "phenylpropanoid metabolism" EXACT []
xref: MetaCyc:PWY1F-467
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0009699
name: phenylpropanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl]
synonym: "phenylpropanoid anabolism" EXACT []
synonym: "phenylpropanoid biosynthesis" EXACT []
synonym: "phenylpropanoid formation" EXACT []
synonym: "phenylpropanoid synthesis" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0009700
name: indole phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684]
synonym: "indole phytoalexin anabolism" EXACT []
synonym: "indole phytoalexin biosynthesis" EXACT []
synonym: "indole phytoalexin formation" EXACT []
synonym: "indole phytoalexin synthesis" EXACT []
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0046217 ! indole phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009701
name: isoflavonoid phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
synonym: "isoflavonoid phytoalexin anabolism" EXACT []
synonym: "isoflavonoid phytoalexin biosynthesis" EXACT []
synonym: "isoflavonoid phytoalexin formation" EXACT []
synonym: "isoflavonoid phytoalexin synthesis" EXACT []
is_a: GO:0009717 ! isoflavonoid biosynthetic process
is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009702
name: L-arabinokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H+." [EC:2.7.1.46, RHEA:20153]
synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT []
synonym: "L-arabinokinase (phosphorylating)" RELATED [EC:2.7.1.46]
xref: EC:2.7.1.46
xref: KEGG_REACTION:R01754
xref: MetaCyc:L-ARABINOKINASE-RXN
xref: RHEA:20153
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0009703
name: nitrate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [RHEA:17913]
synonym: "assimilatory NADH: nitrate reductase activity" RELATED [EC:1.7.1.1]
synonym: "assimilatory NADH:nitrate reductase activity" RELATED [EC:1.7.1.1]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1]
synonym: "NADH-dependent nitrate reductase activity" RELATED [EC:1.7.1.1]
synonym: "NADH-nitrate reductase activity" RELATED [EC:1.7.1.1]
synonym: "NADH:nitrate oxidoreductase activity" RELATED [EC:1.7.1.1]
synonym: "NADH:nitrate reductase activity" EXACT []
synonym: "nitrate reductase (NADH(2)) activity" RELATED [EC:1.7.1.1]
synonym: "nitrate reductase (NADH2)" RELATED [EC:1.7.1.1]
synonym: "nitrite:NAD+ oxidoreductase activity" RELATED [EC:1.7.1.1]
xref: EC:1.7.1.1
xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN
xref: RHEA:17913
is_a: GO:0050463 ! nitrate reductase [NAD(P)H] activity

[Term]
id: GO:0009704
name: de-etiolation
namespace: biological_process
def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr]
is_a: GO:0009416 ! response to light stimulus
relationship: part_of GO:0009640 ! photomorphogenesis

[Term]
id: GO:0009705
name: plant-type vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208]
synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT []
synonym: "tonoplast" EXACT []
synonym: "vacuolar membrane" BROAD []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000325 ! plant-type vacuole

[Term]
id: GO:0009706
name: chloroplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb]
synonym: "chloroplast inner envelope" EXACT []
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009707
name: chloroplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb]
synonym: "chloroplast outer envelope" EXACT []
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009708
name: benzyl isoquinoline alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732]
synonym: "benzyl isoquinoline alkaloid anabolism" EXACT []
synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT []
synonym: "benzyl isoquinoline alkaloid formation" EXACT []
synonym: "benzyl isoquinoline alkaloid synthesis" EXACT []
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process

[Term]
id: GO:0009709
name: terpenoid indole alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html]
synonym: "terpenoid indole alkaloid anabolism" EXACT []
synonym: "terpenoid indole alkaloid biosynthesis" EXACT []
synonym: "terpenoid indole alkaloid formation" EXACT []
synonym: "terpenoid indole alkaloid synthesis" EXACT []
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process

[Term]
id: GO:0009710
name: tropane alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732]
synonym: "tropane alkaloid anabolism" EXACT []
synonym: "tropane alkaloid biosynthesis" EXACT []
synonym: "tropane alkaloid formation" EXACT []
synonym: "tropane alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0046448 ! tropane alkaloid metabolic process

[Term]
id: GO:0009711
name: purine alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai]
synonym: "purine alkaloid anabolism" EXACT []
synonym: "purine alkaloid biosynthesis" EXACT []
synonym: "purine alkaloid formation" EXACT []
synonym: "purine alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0046446 ! purine alkaloid metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0009712
name: catechol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684]
synonym: "catechol metabolic process" RELATED []
synonym: "catechol metabolism" RELATED []
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0009713
name: catechol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
synonym: "catechol anabolism" RELATED []
synonym: "catechol biosynthesis" RELATED []
synonym: "catechol biosynthetic process" RELATED []
synonym: "catechol formation" RELATED []
synonym: "catechol synthesis" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0009714
name: chalcone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732]
synonym: "chalcone metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0009715
name: chalcone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators]
synonym: "chalcone anabolism" EXACT []
synonym: "chalcone biosynthesis" EXACT []
synonym: "chalcone formation" EXACT []
synonym: "chalcone synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009714 ! chalcone metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process

[Term]
id: GO:0009716
name: flavonoid phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732]
synonym: "flavonoid phytoalexin anabolism" EXACT []
synonym: "flavonoid phytoalexin biosynthesis" EXACT []
synonym: "flavonoid phytoalexin formation" EXACT []
synonym: "flavonoid phytoalexin synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046285 ! flavonoid phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009717
name: isoflavonoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai]
synonym: "isoflavonoid anabolism" EXACT []
synonym: "isoflavonoid biosynthesis" EXACT []
synonym: "isoflavonoid formation" EXACT []
synonym: "isoflavonoid synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0046287 ! isoflavonoid metabolic process

[Term]
id: GO:0009718
name: anthocyanin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai]
synonym: "anthocyanin anabolism" EXACT []
synonym: "anthocyanin biosynthesis" EXACT []
synonym: "anthocyanin biosynthetic process" EXACT []
synonym: "anthocyanin formation" EXACT []
synonym: "anthocyanin synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0009719
name: response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_plant
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009720
name: detection of hormone stimulus
namespace: biological_process
def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of hormone stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0009721
name: detection of auxin stimulus
namespace: biological_process
def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of auxin stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009733 ! response to auxin

[Term]
id: GO:0009722
name: detection of cytokinin stimulus
namespace: biological_process
def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of cytokinin stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009735 ! response to cytokinin

[Term]
id: GO:0009723
name: response to ethylene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl]
synonym: "response to ethene stimulus" EXACT []
synonym: "response to ethylene stimulus" EXACT []
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0009724
name: detection of abscisic acid stimulus
namespace: biological_process
def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of abscisic acid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009737 ! response to abscisic acid

[Term]
id: GO:0009725
name: response to hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]
synonym: "growth regulator" RELATED []
synonym: "response to hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0009726
name: obsolete detection of endogenous stimulus
namespace: biological_process
def: "OBSOLETE. The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "perception of endogenous stimulus" RELATED []
is_obsolete: true

[Term]
id: GO:0009727
name: detection of ethylene stimulus
namespace: biological_process
def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "detection of ethene stimulus" EXACT []
synonym: "perception of ethene stimulus" RELATED []
synonym: "perception of ethylene stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009723 ! response to ethylene

[Term]
id: GO:0009728
name: detection of gibberellic acid stimulus
namespace: biological_process
def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of gibberellic acid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009739 ! response to gibberellin

[Term]
id: GO:0009729
name: detection of brassinosteroid stimulus
namespace: biological_process
def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of brassinosteroid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009741 ! response to brassinosteroid

[Term]
id: GO:0009730
name: detection of carbohydrate stimulus
namespace: biological_process
def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of carbohydrate stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0009731
name: detection of sucrose stimulus
namespace: biological_process
def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of sucrose stimulus" RELATED []
is_a: GO:0009744 ! response to sucrose
is_a: GO:0034288 ! detection of disaccharide stimulus

[Term]
id: GO:0009732
name: detection of hexose stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm]
synonym: "perception of hexose stimulus" RELATED []
is_a: GO:0009746 ! response to hexose
is_a: GO:0034287 ! detection of monosaccharide stimulus

[Term]
id: GO:0009733
name: response to auxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl]
synonym: "response to auxin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0009734
name: auxin-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:sm, PMID:16990790, PMID:18647826]
synonym: "auxin mediated signaling pathway" RELATED []
synonym: "auxin mediated signalling" EXACT []
synonym: "auxin signal transduction" EXACT [PMID:16990790]
synonym: "auxin signaling" EXACT [PMID:18647826]
synonym: "auxin-regulated transcription" RELATED [PMID:15917797]
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071365 ! cellular response to auxin stimulus

[Term]
id: GO:0009735
name: response to cytokinin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl]
synonym: "response to cytokinin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0009736
name: cytokinin-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:sm, PMID:24080474]
synonym: "cytokinin mediated signaling pathway" RELATED []
synonym: "cytokinin mediated signalling" EXACT []
synonym: "cytokinin signaling" EXACT [PMID:24080474]
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071368 ! cellular response to cytokinin stimulus

[Term]
id: GO:0009737
name: response to abscisic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl]
synonym: "response to abscisic acid stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0009738
name: abscisic acid-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription." [GOC:signaling, GOC:sm, PMID:24269821]
synonym: "ABA signal transduction" EXACT [PMID:20713515]
synonym: "ABA signaling" EXACT [PMID:24269821]
synonym: "abscisic acid mediated signalling" EXACT []
synonym: "abscisic acid signal transduction" RELATED [PMID:20713515]
synonym: "abscisic acid-mediated signaling pathway" RELATED []
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071215 ! cellular response to abscisic acid stimulus

[Term]
id: GO:0009739
name: response to gibberellin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl]
synonym: "response to gibberellic acid stimulus" NARROW []
synonym: "response to gibberellin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009740
name: gibberellic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm]
synonym: "GA-signaling" EXACT []
synonym: "gibberellic acid mediated signalling" EXACT []
synonym: "gibberellic acid signaling" EXACT []
is_a: GO:0010476 ! gibberellin mediated signaling pathway

[Term]
id: GO:0009741
name: response to brassinosteroid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl]
synonym: "response to brassinosteroid stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009742
name: brassinosteroid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm]
synonym: "brassinosteroid mediated signalling" EXACT []
is_a: GO:0043401 ! steroid hormone receptor signaling pathway
relationship: part_of GO:0071367 ! cellular response to brassinosteroid stimulus

[Term]
id: GO:0009743
name: response to carbohydrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl]
synonym: "response to carbohydrate stimulus" EXACT [GOC:dos]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009744
name: response to sucrose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
synonym: "response to sucrose stimulus" EXACT [GOC:dos]
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0009745
name: sucrose mediated signaling
namespace: biological_process
def: "The series of molecular signals mediated by the detection of sucrose." [GOC:sm]
synonym: "sucrose mediated signalling" EXACT []
is_a: GO:0010182 ! sugar mediated signaling pathway
relationship: part_of GO:0071329 ! cellular response to sucrose stimulus

[Term]
id: GO:0009746
name: response to hexose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl]
synonym: "response to hexose stimulus" EXACT [GOC:dos]
is_a: GO:0034284 ! response to monosaccharide

[Term]
id: GO:0009747
name: hexokinase-dependent signaling
namespace: biological_process
def: "The series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm]
synonym: "hexokinase-dependent signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling

[Term]
id: GO:0009748
name: hexokinase-independent signaling
namespace: biological_process
def: "The series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm]
synonym: "hexokinase-independent signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling

[Term]
id: GO:0009749
name: response to glucose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl]
synonym: "response to glucose stimulus" EXACT [GOC:dos]
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:0009750
name: response to fructose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl]
synonym: "response to fructose stimulus" EXACT [GOC:dos]
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:0009751
name: response to salicylic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl]
synonym: "response to salicylate" EXACT [GOC:dph]
synonym: "response to salicylic acid stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009752
name: detection of salicylic acid stimulus
namespace: biological_process
def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of salicylic acid stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009751 ! response to salicylic acid

[Term]
id: GO:0009753
name: response to jasmonic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl]
synonym: "response to jasmonic acid stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0009754
name: detection of jasmonic acid stimulus
namespace: biological_process
def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm]
synonym: "perception of jasmonic acid stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009753 ! response to jasmonic acid

[Term]
id: GO:0009755
name: hormone-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the detection of a hormone." [GOC:sm]
synonym: "hormone mediated signalling" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0009756
name: carbohydrate mediated signaling
namespace: biological_process
def: "The series of molecular signals mediated by the detection of carbohydrate." [GOC:sm]
synonym: "carbohydrate mediated signalling" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0009757
name: hexose mediated signaling
namespace: biological_process
def: "The series of molecular signals mediated by the detection of hexose." [GOC:sm]
synonym: "hexose mediated signalling" EXACT []
is_a: GO:0010182 ! sugar mediated signaling pathway
relationship: part_of GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0009758
name: carbohydrate utilization
namespace: biological_process
alt_id: GO:0007587
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mcc2, GOC:mlg]
synonym: "sugar utilization" NARROW [GOC:mcc2]
is_a: GO:0031667 ! response to nutrient levels

[Term]
id: GO:0009759
name: indole glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai]
synonym: "indole glucosinolate anabolism" EXACT []
synonym: "indole glucosinolate biosynthesis" EXACT []
synonym: "indole glucosinolate formation" EXACT []
synonym: "indole glucosinolate synthesis" EXACT []
is_a: GO:0019761 ! glucosinolate biosynthetic process
is_a: GO:0042343 ! indole glucosinolate metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process

[Term]
id: GO:0009760
name: C4 photosynthesis
namespace: biological_process
def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360]
xref: Wikipedia:C4_carbon_fixation
is_a: GO:0015977 ! carbon fixation
is_a: GO:0019685 ! photosynthesis, dark reaction

[Term]
id: GO:0009761
name: CAM photosynthesis
namespace: biological_process
def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952]
xref: Wikipedia:Crassulacean_acid_metabolism
is_a: GO:0015977 ! carbon fixation
is_a: GO:0019685 ! photosynthesis, dark reaction

[Term]
id: GO:0009762
name: NADP-malic enzyme C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762]
xref: MetaCyc:PWY-241
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009763
name: NAD-malic enzyme C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762]
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009764
name: PEP carboxykinase C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762]
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009765
name: photosynthesis, light harvesting
namespace: biological_process
def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm]
synonym: "energy dissipation" RELATED []
is_a: GO:0006091 ! generation of precursor metabolites and energy
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009766
name: obsolete primary charge separation
namespace: biological_process
def: "OBSOLETE. In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431]
comment: This term was obsoleted because it represents a mechanism, and is outside the scope of GO.
is_obsolete: true

[Term]
id: GO:0009767
name: photosynthetic electron transport chain
namespace: biological_process
alt_id: GO:0009774
alt_id: GO:0009775
alt_id: GO:0009776
def: "A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684]
synonym: "electron carrier, chlorophyll electron transport system" EXACT []
synonym: "photosynthetic electron transport in cytochrome b6/f" NARROW []
synonym: "photosynthetic electron transport in plastocyanin" NARROW []
synonym: "photosynthetic electron transport in plastoquinone" NARROW []
is_a: GO:0022900 ! electron transport chain
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009768
name: photosynthesis, light harvesting in photosystem I
namespace: biological_process
def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0009769
name: photosynthesis, light harvesting in photosystem II
namespace: biological_process
def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0009770
name: obsolete primary charge separation in photosystem I
namespace: biological_process
def: "OBSOLETE. Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
comment: This term was obsoleted because it represents a mechanism, and is outside the scope of GO.
is_obsolete: true

[Term]
id: GO:0009771
name: obsolete primary charge separation in photosystem II
namespace: biological_process
def: "OBSOLETE. Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
comment: This term was obsoleted because it represents a mechanism, and is outside the scope of GO.
is_obsolete: true

[Term]
id: GO:0009772
name: photosynthetic electron transport in photosystem II
namespace: biological_process
def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009773
name: photosynthetic electron transport in photosystem I
namespace: biological_process
def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009777
name: photosynthetic phosphorylation
namespace: biological_process
def: "Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684]
synonym: "photosynthetic ATP synthesis" NARROW []
is_a: GO:0016310 ! phosphorylation
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009778
name: cyclic photosynthetic phosphorylation
namespace: biological_process
def: "A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684]
is_a: GO:0009777 ! photosynthetic phosphorylation

[Term]
id: GO:0009779
name: noncyclic photosynthetic phosphorylation
namespace: biological_process
def: "A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684]
is_a: GO:0009777 ! photosynthetic phosphorylation

[Term]
id: GO:0009780
name: photosynthetic NADP+ reduction
namespace: biological_process
def: "An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jid, ISBN:0716746840, ISBN:0816017360]
is_a: GO:0006740 ! NADPH regeneration
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009781
name: obsolete photosynthetic water oxidation
namespace: biological_process
def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jid, ISBN:0716743663, ISBN:0816017360]
comment: This term was made obsolete because it represents a molecular function.
synonym: "photosynthetic water oxidation" EXACT []
is_obsolete: true
replaced_by: GO:0010242

[Term]
id: GO:0009782
name: photosystem I antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009783
name: photosystem II antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009784
name: transmembrane receptor histidine kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah]
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0009785
name: blue light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm]
synonym: "blue light signalling pathway" EXACT []
is_a: GO:0030522 ! intracellular receptor signaling pathway
is_a: GO:0071483 ! cellular response to blue light

[Term]
id: GO:0009786
name: regulation of asymmetric cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr]
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0009787
name: regulation of abscisic acid-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr]
synonym: "regulation of abscisic acid mediated signaling pathway" RELATED []
synonym: "regulation of abscisic acid mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1905957 ! regulation of cellular response to alcohol
relationship: regulates GO:0009738 ! abscisic acid-activated signaling pathway

[Term]
id: GO:0009788
name: negative regulation of abscisic acid-activated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr]
synonym: "down regulation of abscisic acid mediated signaling" EXACT []
synonym: "down-regulation of abscisic acid mediated signaling" EXACT []
synonym: "downregulation of abscisic acid mediated signaling" EXACT []
synonym: "inhibition of abscisic acid mediated signaling" NARROW []
synonym: "negative regulation of abscisic acid mediated signaling pathway" RELATED []
synonym: "negative regulation of abscisic acid mediated signalling" EXACT []
is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1905958 ! negative regulation of cellular response to alcohol
relationship: negatively_regulates GO:0009738 ! abscisic acid-activated signaling pathway

[Term]
id: GO:0009789
name: positive regulation of abscisic acid-activated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr]
synonym: "activation of abscisic acid mediated signaling" NARROW []
synonym: "positive regulation of abscisic acid mediated signaling pathway" RELATED []
synonym: "positive regulation of abscisic acid mediated signalling" EXACT []
synonym: "stimulation of abscisic acid mediated signaling" NARROW []
synonym: "up regulation of abscisic acid mediated signaling" EXACT []
synonym: "up-regulation of abscisic acid mediated signaling" EXACT []
synonym: "upregulation of abscisic acid mediated signaling" EXACT []
is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0009738 ! abscisic acid-activated signaling pathway

[Term]
id: GO:0009790
name: embryo development
namespace: biological_process
alt_id: GO:0009795
def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_plant
synonym: "embryogenesis" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "embryonal development" EXACT []
xref: Wikipedia:Embryogenesis
is_a: GO:0007275 ! multicellular organism development

[Term]
id: GO:0009791
name: post-embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0009792
name: embryo development ending in birth or egg hatching
namespace: biological_process
def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0009790 ! embryo development

[Term]
id: GO:0009793
name: embryo development ending in seed dormancy
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009790 ! embryo development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0009794
name: regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "embryonic mitotic cell cycle modulation" EXACT []
synonym: "embryonic mitotic cell cycle regulation" EXACT []
synonym: "embryonic mitotic cell cycle regulator" RELATED []
synonym: "modulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0009798
name: axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "axis determination" RELATED []
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0009799
name: specification of symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators]
synonym: "determination of symmetry" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0009800
name: cinnamic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl]
synonym: "cinnamic acid anabolism" EXACT []
synonym: "cinnamic acid biosynthesis" EXACT []
synonym: "cinnamic acid formation" EXACT []
synonym: "cinnamic acid synthesis" EXACT []
synonym: "cinnamylic acid biosynthesis" EXACT []
synonym: "cinnamylic acid biosynthetic process" EXACT []
synonym: "phenylacrylic acid biosynthesis" EXACT []
synonym: "phenylacrylic acid biosynthetic process" EXACT []
synonym: "phenylpropenoic acid biosynthesis" EXACT []
synonym: "phenylpropenoic acid biosynthetic process" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009803 ! cinnamic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process

[Term]
id: GO:0009801
name: cinnamic acid ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl]
synonym: "cinnamic acid ester metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0009802
name: cinnamic acid ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl]
synonym: "cinnamic acid ester anabolism" EXACT []
synonym: "cinnamic acid ester biosynthesis" EXACT []
synonym: "cinnamic acid ester formation" EXACT []
synonym: "cinnamic acid ester synthesis" EXACT []
synonym: "cinnamylic acid ester biosynthesis" EXACT []
synonym: "cinnamylic acid ester biosynthetic process" EXACT []
synonym: "phenylacrylic acid ester biosynthesis" EXACT []
synonym: "phenylacrylic acid ester biosynthetic process" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009801 ! cinnamic acid ester metabolic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
relationship: part_of GO:0009803 ! cinnamic acid metabolic process

[Term]
id: GO:0009803
name: cinnamic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl]
synonym: "cinnamic acid metabolism" EXACT []
synonym: "cinnamylic acid metabolic process" EXACT []
synonym: "cinnamylic acid metabolism" EXACT []
synonym: "phenylacrylic acid metabolic process" EXACT []
synonym: "phenylacrylic acid metabolism" EXACT []
synonym: "phenylpropenoic acid metabolic process" EXACT []
synonym: "phenylpropenoic acid metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0009804
name: coumarin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl]
synonym: "coumarin metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009805
name: coumarin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl]
synonym: "coumarin anabolism" EXACT []
synonym: "coumarin biosynthesis" EXACT []
synonym: "coumarin formation" EXACT []
synonym: "coumarin synthesis" EXACT []
xref: MetaCyc:PWY-5176
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009804 ! coumarin metabolic process

[Term]
id: GO:0009806
name: lignan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
synonym: "lignan metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009807
name: lignan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
synonym: "lignan anabolism" EXACT []
synonym: "lignan biosynthesis" EXACT []
synonym: "lignan formation" EXACT []
synonym: "lignan synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009806 ! lignan metabolic process

[Term]
id: GO:0009808
name: lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl]
synonym: "lignin metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009809
name: lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684]
synonym: "lignin anabolism" EXACT []
synonym: "lignin biosynthesis" EXACT []
synonym: "lignin formation" EXACT []
synonym: "lignin synthesis" EXACT []
xref: MetaCyc:PWY-361
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009808 ! lignin metabolic process

[Term]
id: GO:0009810
name: stilbene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:3110116251]
synonym: "stilbene metabolism" EXACT []
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0009811
name: stilbene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251]
synonym: "stilbene anabolism" EXACT []
synonym: "stilbene biosynthesis" EXACT []
synonym: "stilbene formation" EXACT []
synonym: "stilbene synthesis" EXACT []
is_a: GO:0009810 ! stilbene metabolic process
is_a: GO:0120255 ! olefinic compound biosynthetic process

[Term]
id: GO:0009812
name: flavonoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684]
synonym: "flavonoid metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009813
name: flavonoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684]
synonym: "flavonoid anabolism" EXACT []
synonym: "flavonoid biosynthesis" EXACT []
synonym: "flavonoid formation" EXACT []
synonym: "flavonoid synthesis" EXACT []
xref: MetaCyc:PWY1F-FLAVSYN
xref: Wikipedia:Flavonoid
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0009815
name: 1-aminocyclopropane-1-carboxylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + dehydroascorbate + ethylene + 2 H2O + hydrogen cyanide. Ethene is also known as ethylene." [RHEA:23640]
synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" RELATED [EC:1.14.17.4]
synonym: "ACC oxidase activity" EXACT []
synonym: "aminocyclopropanecarboxylate oxidase activity" RELATED [EC:1.14.17.4]
synonym: "ethene-forming enzyme" BROAD []
synonym: "ethylene-forming enzyme" BROAD []
xref: EC:1.14.17.4
xref: KEGG_REACTION:R07214
xref: MetaCyc:ETHYL-RXN
xref: RHEA:23640
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0009819
name: drought recovery
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr]
synonym: "drought tolerance" RELATED []
is_a: GO:0009414 ! response to water deprivation

[Term]
id: GO:0009820
name: alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
subset: goslim_chembl
synonym: "alkaloid metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009821
name: alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
synonym: "alkaloid anabolism" EXACT []
synonym: "alkaloid biosynthesis" EXACT []
synonym: "alkaloid formation" EXACT []
synonym: "alkaloid synthesis" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0009822
name: alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
synonym: "alkaloid breakdown" EXACT []
synonym: "alkaloid catabolism" EXACT []
synonym: "alkaloid degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0009820 ! alkaloid metabolic process

[Term]
id: GO:0009823
name: cytokinin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr]
synonym: "cytokinin breakdown" EXACT []
synonym: "cytokinin catabolism" EXACT []
synonym: "cytokinin degradation" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0009824
name: AMP dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate." [RHEA:15285]
synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT []
synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [KEGG_REACTION:R04038]
synonym: "adenylate dimethylallyltransferase (AMP-dependent) activity" EXACT []
synonym: "adenylate dimethylallyltransferase activity" RELATED [EC:2.5.1.27]
synonym: "adenylate isopentenyltransferase activity" BROAD []
synonym: "cytokinin synthase activity" BROAD []
synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" RELATED [EC:2.5.1.27]
synonym: "isopentenyltransferase activity" BROAD []
xref: EC:2.5.1.27
xref: KEGG_REACTION:R04038
xref: MetaCyc:RXN-4307
xref: RHEA:15285
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0009825
name: multidimensional cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399]
synonym: "cell growth in three dimensions" EXACT []
synonym: "cell growth in two dimensions" NARROW []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0009826
name: unidimensional cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399]
comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children.
synonym: "cell elongation" NARROW []
synonym: "cell growth along one axis" EXACT []
synonym: "cell growth in one dimension" EXACT []
synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb]
synonym: "polar cell growth" EXACT []
synonym: "polarized cell growth" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0016049 ! cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis

[Term]
id: GO:0009827
name: plant-type cell wall modification
namespace: biological_process
def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing cell wall modification" EXACT []
is_a: GO:0009664 ! plant-type cell wall organization
is_a: GO:0042545 ! cell wall modification

[Term]
id: GO:0009828
name: plant-type cell wall loosening
namespace: biological_process
def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing cell wall loosening" EXACT []
is_a: GO:0009827 ! plant-type cell wall modification

[Term]
id: GO:0009829
name: cell wall modification involved in fruit ripening
namespace: biological_process
def: "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening." [GOC:lr]
synonym: "cell wall modification during ripening" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0009835 ! fruit ripening

[Term]
id: GO:0009830
name: cell wall modification involved in abscission
namespace: biological_process
def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb]
synonym: "cell wall modification during abscission" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0044277 ! cell wall disassembly
relationship: part_of GO:0009838 ! abscission

[Term]
id: GO:0009831
name: plant-type cell wall modification involved in multidimensional cell growth
namespace: biological_process
def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cell wall modification during cell expansion" BROAD []
synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" RELATED []
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0042547 ! cell wall modification involved in multidimensional cell growth

[Term]
id: GO:0009832
name: plant-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu]
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT []
is_a: GO:0042546 ! cell wall biogenesis
is_a: GO:0071669 ! plant-type cell wall organization or biogenesis

[Term]
id: GO:0009833
name: plant-type primary cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT []
synonym: "primary cell wall anabolism" BROAD []
synonym: "primary cell wall biogenesis" EXACT []
synonym: "primary cell wall biosynthetic process" BROAD []
synonym: "primary cell wall formation" BROAD []
synonym: "primary cell wall synthesis" BROAD []
is_a: GO:0009832 ! plant-type cell wall biogenesis
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:0009834
name: plant-type secondary cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT []
synonym: "secondary cell wall anabolism" BROAD []
synonym: "secondary cell wall biogenesis" EXACT []
synonym: "secondary cell wall biosynthetic process" BROAD []
synonym: "secondary cell wall formation" BROAD []
synonym: "secondary cell wall synthesis" BROAD []
is_a: GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0009835
name: fruit ripening
namespace: biological_process
def: "An developmental maturation process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal." [GOC:lr]
subset: goslim_plant
synonym: "fruit maturation" RELATED [GOC:PO_curators]
synonym: "fruit senescence" RELATED [GOC:PO_curators]
xref: Wikipedia:Ripening
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0009836
name: fruit ripening, climacteric
namespace: biological_process
def: "A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840]
is_a: GO:0009835 ! fruit ripening

[Term]
id: GO:0009837
name: fruit ripening, non-climacteric
namespace: biological_process
def: "A fruit ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840]
is_a: GO:0009835 ! fruit ripening

[Term]
id: GO:0009838
name: abscission
namespace: biological_process
def: "The controlled shedding of a body part." [ISBN:0140514031]
subset: goslim_plant
xref: Wikipedia:Abscission
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0009839
name: obsolete SCF complex substrate recognition subunit
namespace: cellular_component
def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "SCF complex substrate recognition subunit" EXACT []
is_obsolete: true
replaced_by: GO:0019005

[Term]
id: GO:0009840
name: chloroplastic endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009841
name: mitochondrial endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0009842
name: cyanelle
namespace: cellular_component
def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:0521316871, ISBN:1402001894]
synonym: "cyanoplast" EXACT [ISBN:1402001894]
synonym: "muroplast" EXACT [ISBN:1402001894]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009843
name: cyanelle thylakoid
namespace: cellular_component
def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu]
is_a: GO:0031976 ! plastid thylakoid
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0009844
name: obsolete germination
namespace: biological_process
alt_id: GO:0009565
def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr]
comment: This term was made obsolete because it is a grouping term without biological significance.
synonym: "germination" EXACT []
is_obsolete: true

[Term]
id: GO:0009845
name: seed germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041]
xref: Wikipedia:Germination#Seed_germination
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0090351 ! seedling development

[Term]
id: GO:0009846
name: pollen germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, ISBN:0943088399, PMID:30669423]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0009847
name: spore germination
namespace: biological_process
alt_id: GO:0075005
def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr]
synonym: "spore germination on or near host" NARROW []
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0009848
name: indoleacetic acid biosynthetic process via tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566]
synonym: "IAA biosynthetic process via tryptophan" EXACT []
synonym: "indoleacetic acid anabolism via tryptophan" EXACT []
synonym: "indoleacetic acid formation via tryptophan" EXACT []
synonym: "indoleacetic acid synthesis via tryptophan" EXACT []
xref: MetaCyc:PWY-581
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009684 ! indoleacetic acid biosynthetic process

[Term]
id: GO:0009849
name: tryptophan-independent indoleacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566]
synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT []
synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT []
synonym: "tryptophan-independent IAA biosynthetic process" EXACT []
synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT []
synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT []
synonym: "tryptophan-independent indoleacetic acid formation" EXACT []
synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT []
is_a: GO:0009684 ! indoleacetic acid biosynthetic process

[Term]
id: GO:0009850
name: auxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr]
synonym: "auxin metabolism" EXACT []
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0009851
name: auxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743]
synonym: "auxin anabolism" EXACT []
synonym: "auxin biosynthesis" EXACT []
synonym: "auxin formation" EXACT []
synonym: "auxin synthesis" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0009852
name: auxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684]
synonym: "auxin breakdown" EXACT []
synonym: "auxin catabolism" EXACT []
synonym: "auxin degradation" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0009853
name: photorespiration
namespace: biological_process
def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732]
synonym: "photorespiratory pathway" EXACT [GOC:cjm]
xref: MetaCyc:PWY-181
xref: Wikipedia:Photorespiration
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0009854
name: oxidative photosynthetic carbon pathway
namespace: biological_process
def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:0943088399]
is_a: GO:0043094 ! cellular metabolic compound salvage
relationship: part_of GO:0009853 ! photorespiration

[Term]
id: GO:0009855
name: determination of bilateral symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators]
synonym: "determination of bilateral asymmetry" EXACT [GOC:dph]
is_a: GO:0009799 ! specification of symmetry

[Term]
id: GO:0009856
name: pollination
namespace: biological_process
def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion." [GOC:tb, PMID:10973091]
subset: goslim_plant
subset: goslim_plant_ribbon
xref: Wikipedia:Pollination
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0044706 ! multi-multicellular organism process

[Term]
id: GO:0009858
name: obsolete compatible pollen-pistil interaction
namespace: biological_process
def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
synonym: "compatible pollen-pistil interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0009859
name: pollen hydration
namespace: biological_process
def: "The process in which water is taken up by pollen." [GOC:lr]
is_a: GO:0006833 ! water transport
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0009860
name: pollen tube growth
namespace: biological_process
def: "Growth of pollen via tip extension of the intine wall." [ISBN:0943088399]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009932 ! cell tip growth
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0009861
name: jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273]
synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT []
is_a: GO:0009611 ! response to wounding
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0009862
name: systemic acquired resistance, salicylic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy]
synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT []
synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT []
is_a: GO:0009863 ! salicylic acid mediated signaling pathway
relationship: part_of GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0009863
name: salicylic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by salicylic acid." [GOC:jy]
synonym: "salicylic acid mediated signal transduction" EXACT [GOC:signaling]
synonym: "salicylic acid mediated signalling pathway" EXACT []
synonym: "salicylic acid-mediated signaling pathway" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071446 ! cellular response to salicylic acid stimulus

[Term]
id: GO:0009864
name: induced systemic resistance, jasmonic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy]
synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002252 ! immune effector process
is_a: GO:0009867 ! jasmonic acid mediated signaling pathway
relationship: part_of GO:0009682 ! induced systemic resistance

[Term]
id: GO:0009865
name: pollen tube adhesion
namespace: biological_process
def: "The process in which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877]
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0009875 ! pollen-pistil interaction
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0009866
name: induced systemic resistance, ethylene mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy]
synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT []
synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT []
synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT []
synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002252 ! immune effector process
is_a: GO:0009873 ! ethylene-activated signaling pathway
relationship: part_of GO:0009682 ! induced systemic resistance

[Term]
id: GO:0009867
name: jasmonic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by jasmonic acid." [GOC:jy, PMID:16478936, PMID:19522558, PMID:20159850]
synonym: "JA signaling" EXACT [PMID:20159850]
synonym: "jasmonate signaling" RELATED [PMID:16478936]
synonym: "jasmonic acid mediated signalling pathway" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071395 ! cellular response to jasmonic acid stimulus

[Term]
id: GO:0009868
name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy]
synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
is_a: GO:0009867 ! jasmonic acid mediated signaling pathway
relationship: part_of GO:0032260 ! response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0009869
name: obsolete incompatible pollen-pistil interaction
namespace: biological_process
def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566]
comment: This term was made obsolete because it represents a phenotype.
synonym: "incompatible pollen-pistil interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0009871
name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy]
synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT []
synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT []
is_a: GO:0009873 ! ethylene-activated signaling pathway
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0009872
name: obsolete gametophytic self-incompatibility
namespace: biological_process
def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
synonym: "gametophytic self-incompatibility" EXACT []
is_obsolete: true

[Term]
id: GO:0009873
name: ethylene-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription." [GOC:jy, PMID:24012247]
synonym: "ethene mediated signaling pathway" RELATED []
synonym: "ethene mediated signalling pathway" EXACT []
synonym: "ethylene mediated signaling pathway" RELATED []
synonym: "ethylene mediated signalling pathway" RELATED []
synonym: "ethylene signal transduction" RELATED [PMID:24012247]
synonym: "ethylene signaling pathway" RELATED [PMID:24287137]
is_a: GO:0000160 ! phosphorelay signal transduction system
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071369 ! cellular response to ethylene stimulus

[Term]
id: GO:0009874
name: obsolete sporophytic self-incompatibility
namespace: biological_process
def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
synonym: "sporophytic self-incompatibility" EXACT []
is_obsolete: true

[Term]
id: GO:0009875
name: pollen-pistil interaction
namespace: biological_process
def: "The interaction between a pollen grain and pistil." [PMID:27899537]
synonym: "pollen-gynoecium interaction" EXACT []
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0009876
name: pollen adhesion
namespace: biological_process
def: "The process in which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0009877
name: nodulation
namespace: biological_process
alt_id: GO:0009878
def: "The formation of nitrogen-fixing root nodules on plant roots." [PMID:21856632, PMID:33317178]
synonym: "nodule development" EXACT [GOC:jl]
synonym: "nodule formation" EXACT [GOC:jl]
synonym: "nodule morphogenesis" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0009879
name: determination of radial symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators]
synonym: "determination of radial asymmetry" EXACT [GOC:dph]
is_a: GO:0009799 ! specification of symmetry
relationship: part_of GO:0009956 ! radial pattern formation

[Term]
id: GO:0009880
name: embryonic pattern specification
namespace: biological_process
def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
synonym: "embryonic pattern biosynthesis" BROAD []
synonym: "embryonic pattern formation" BROAD []
synonym: "ventral/lateral system" RELATED []
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0009881
name: photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
synonym: "blue-sensitive opsin" NARROW []
synonym: "green-sensitive opsin" NARROW []
synonym: "long-wave-sensitive opsin" NARROW []
synonym: "opsin" NARROW []
synonym: "red-sensitive opsin" NARROW []
synonym: "short-wave-sensitive opsin" NARROW []
synonym: "UV-sensitive opsin" NARROW []
synonym: "violet-sensitive opsin" NARROW []
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0009882
name: blue light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]
is_a: GO:0009881 ! photoreceptor activity

[Term]
id: GO:0009883
name: red or far-red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr]
synonym: "red/far-red light photoreceptor activity" EXACT []
is_a: GO:0009881 ! photoreceptor activity

[Term]
id: GO:0009884
name: cytokinin receptor activity
namespace: molecular_function
def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:lr, GOC:signaling]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0009885
name: transmembrane histidine kinase cytokinin receptor activity
namespace: molecular_function
def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah]
is_a: GO:0009784 ! transmembrane receptor histidine kinase activity
is_a: GO:0009884 ! cytokinin receptor activity

[Term]
id: GO:0009886
name: post-embryonic animal morphogenesis
namespace: biological_process
def: "The process, occurring after animal embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators]
synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0009887
name: animal organ morphogenesis
namespace: biological_process
def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
synonym: "histogenesis and organogenesis" BROAD []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0009888
name: tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
synonym: "histogenesis" EXACT []
synonym: "histogenesis and organogenesis" BROAD []
xref: Wikipedia:Histogenesis
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0009889
name: regulation of biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "regulation of anabolism" EXACT []
synonym: "regulation of biosynthesis" EXACT []
synonym: "regulation of formation" EXACT []
synonym: "regulation of synthesis" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009890
name: negative regulation of biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "down regulation of biosynthetic process" EXACT []
synonym: "down-regulation of biosynthetic process" EXACT []
synonym: "downregulation of biosynthetic process" EXACT []
synonym: "inhibition of biosynthetic process" NARROW []
synonym: "negative regulation of anabolism" EXACT []
synonym: "negative regulation of biosynthesis" EXACT []
synonym: "negative regulation of formation" EXACT []
synonym: "negative regulation of synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009892 ! negative regulation of metabolic process
relationship: negatively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009891
name: positive regulation of biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "activation of biosynthetic process" NARROW []
synonym: "positive regulation of anabolism" EXACT []
synonym: "positive regulation of biosynthesis" EXACT []
synonym: "positive regulation of formation" EXACT []
synonym: "positive regulation of synthesis" EXACT []
synonym: "stimulation of biosynthetic process" NARROW []
synonym: "up regulation of biosynthetic process" EXACT []
synonym: "up-regulation of biosynthetic process" EXACT []
synonym: "upregulation of biosynthetic process" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009893 ! positive regulation of metabolic process
relationship: positively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009892
name: negative regulation of metabolic process
namespace: biological_process
alt_id: GO:0044252
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
synonym: "down regulation of metabolic process" EXACT []
synonym: "down-regulation of metabolic process" EXACT []
synonym: "downregulation of metabolic process" EXACT []
synonym: "inhibition of metabolic process" NARROW []
synonym: "inhibition of organismal metabolic process" NARROW []
synonym: "negative regulation of metabolism" EXACT []
synonym: "negative regulation of multicellular organismal metabolic process" NARROW []
synonym: "negative regulation of organismal metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009893
name: positive regulation of metabolic process
namespace: biological_process
alt_id: GO:0044253
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
synonym: "activation of metabolic process" NARROW []
synonym: "positive regulation of metabolism" EXACT []
synonym: "positive regulation of multicellular organismal metabolic process" NARROW []
synonym: "positive regulation of organismal metabolism" NARROW []
synonym: "stimulation of metabolic process" NARROW []
synonym: "stimulation of organismal metabolic process" NARROW []
synonym: "up regulation of metabolic process" EXACT []
synonym: "up-regulation of metabolic process" EXACT []
synonym: "up-regulation of organismal metabolic process" NARROW []
synonym: "upregulation of metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009894
name: regulation of catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "regulation of breakdown" EXACT []
synonym: "regulation of catabolism" EXACT []
synonym: "regulation of degradation" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009895
name: negative regulation of catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "down regulation of catabolic process" EXACT []
synonym: "down-regulation of catabolic process" EXACT []
synonym: "downregulation of catabolic process" EXACT []
synonym: "inhibition of catabolic process" NARROW []
synonym: "negative regulation of breakdown" EXACT []
synonym: "negative regulation of catabolism" EXACT []
synonym: "negative regulation of degradation" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
relationship: negatively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009896
name: positive regulation of catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "activation of catabolic process" NARROW []
synonym: "positive regulation of breakdown" EXACT []
synonym: "positive regulation of catabolism" EXACT []
synonym: "positive regulation of degradation" EXACT []
synonym: "stimulation of catabolic process" NARROW []
synonym: "up regulation of catabolic process" EXACT []
synonym: "up-regulation of catabolic process" EXACT []
synonym: "upregulation of catabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
relationship: positively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009897
name: external side of plasma membrane
namespace: cellular_component
def: "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
synonym: "external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "juxtamembrane" BROAD []
synonym: "outer surface of cytoplasmic membrane" EXACT []
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0009898
name: cytoplasmic side of plasma membrane
namespace: cellular_component
def: "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
synonym: "internal leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "internal side of plasma membrane" EXACT []
synonym: "juxtamembrane" BROAD []
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0009899
name: ent-kaurene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate." [EC:4.2.3.19, RHEA:22220]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" RELATED [EC:4.2.3.19]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" RELATED [EC:4.2.3.19]
synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19]
synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19]
xref: EC:4.2.3.19
xref: KEGG_REACTION:R05092
xref: MetaCyc:4.2.3.19-RXN
xref: RHEA:22220
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0009900
name: dehiscence
namespace: biological_process
def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322]
xref: Wikipedia:Dehiscence_(botany)
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0009901
name: anther dehiscence
namespace: biological_process
def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb]
is_a: GO:0009900 ! dehiscence
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0009902
name: chloroplast relocation
namespace: biological_process
def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623]
synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957]
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0019750 ! chloroplast localization
is_a: GO:0051667 ! establishment of plastid localization

[Term]
id: GO:0009903
name: chloroplast avoidance movement
namespace: biological_process
def: "The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863]
synonym: "high-fluence-rate response" RELATED []
is_a: GO:0009902 ! chloroplast relocation

[Term]
id: GO:0009904
name: chloroplast accumulation movement
namespace: biological_process
def: "The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863]
synonym: "low-fluence-rate response" RELATED []
is_a: GO:0009902 ! chloroplast relocation

[Term]
id: GO:0009905
name: ent-copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, RHEA:14841]
synonym: "diterpene cyclase activity" BROAD []
synonym: "ent-copalyl-diphosphate lyase (decyclizing)" RELATED [EC:5.5.1.13]
synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13]
synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13]
xref: EC:5.5.1.13
xref: KEGG_REACTION:R02068
xref: MetaCyc:5.5.1.13-RXN
xref: RHEA:14841
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0009906
name: response to photoperiod, blue light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009637 ! response to blue light
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0009907
name: response to photoperiod, red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009648 ! photoperiodism
is_a: GO:0010114 ! response to red light

[Term]
id: GO:0009908
name: flower development
namespace: biological_process
alt_id: GO:0048409
def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322]
subset: goslim_plant
subset: goslim_plant_ribbon
is_a: GO:0090567 ! reproductive shoot system development

[Term]
id: GO:0009909
name: regulation of flower development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048831 ! regulation of shoot system development
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0009908 ! flower development

[Term]
id: GO:0009910
name: negative regulation of flower development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of flower development." [GOC:go_curators]
synonym: "down regulation of flower development" EXACT []
synonym: "down-regulation of flower development" EXACT []
synonym: "downregulation of flower development" EXACT []
synonym: "inhibition of flower development" NARROW []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0009908 ! flower development

[Term]
id: GO:0009911
name: positive regulation of flower development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators]
synonym: "activation of flower development" NARROW []
synonym: "stimulation of flower development" NARROW []
synonym: "up regulation of flower development" EXACT []
synonym: "up-regulation of flower development" EXACT []
synonym: "upregulation of flower development" EXACT []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0009908 ! flower development

[Term]
id: GO:0009912
name: auditory receptor cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr]
synonym: "auditory hair cell fate commitment" EXACT []
is_a: GO:0060120 ! inner ear receptor cell fate commitment
relationship: part_of GO:0042491 ! inner ear auditory receptor cell differentiation

[Term]
id: GO:0009913
name: epidermal cell differentiation
namespace: biological_process
alt_id: GO:0043355
def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0008544 ! epidermis development

[Term]
id: GO:0009914
name: hormone transport
namespace: biological_process
def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]
subset: goslim_pir
is_a: GO:0006810 ! transport
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0009915
name: phloem sucrose loading
namespace: biological_process
def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm]
is_a: GO:0015770 ! sucrose transport
is_a: GO:0110126 ! phloem loading

[Term]
id: GO:0009916
name: alternative oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399]
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0009917
name: obsolete sterol 5-alpha reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399]
comment: This term was obsoleted because it represents the same activity as 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) ; GO:0047751.
is_obsolete: true
replaced_by: GO:0047751

[Term]
id: GO:0009918
name: obsolete sterol delta7 reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399]
comment: This term was obsoleted because it represents the same reaction as 7-dehydrocholesterol reductase activity ; GO:0047598.
synonym: "sterol delta-7 reductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047598

[Term]
id: GO:0009919
name: obsolete cytokinesis (sensu Viridiplantae)
namespace: biological_process
def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb]
comment: This term was made obsolete because its meaning was changed significantly.
synonym: "cytokinesis (sensu Viridiplantae)" EXACT []
is_obsolete: true
consider: GO:0000911

[Term]
id: GO:0009920
name: cell plate formation involved in plant-type cell wall biogenesis
namespace: biological_process
def: "The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322]
synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT []
is_a: GO:0000919 ! cell plate assembly
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0009921
name: auxin efflux carrier complex
namespace: cellular_component
def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0009922
name: fatty acid elongase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:32727]
synonym: "condensing enzyme" BROAD []
synonym: "elongation of very long chain fatty acids activity" EXACT []
synonym: "ELOVL" EXACT []
synonym: "very-long-chain 3-ketoacyl-CoA synthase" EXACT []
synonym: "very-long-chain 3-oxoacyl-CoA synthase" EXACT []
synonym: "very-long-chain beta-ketoacyl-CoA synthase" EXACT []
xref: EC:2.3.1.199
xref: MetaCyc:RXN-7697
xref: Reactome:R-HSA-2046083 "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA"
xref: Reactome:R-HSA-2046088 "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA"
xref: Reactome:R-HSA-2046090 "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA"
xref: Reactome:R-HSA-2046094 "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA"
xref: Reactome:R-HSA-2046095 "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA"
xref: Reactome:R-HSA-2046100 "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA"
xref: Reactome:R-HSA-548800 "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA"
xref: Reactome:R-HSA-548814 "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA"
xref: Reactome:R-HSA-548815 "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA"
xref: Reactome:R-HSA-548830 "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA"
xref: RHEA:32727
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0009923
name: fatty acid elongase complex
namespace: cellular_component
def: "A tetrameric complex of four different subunits which catalyzes the elongation of a fatty acid chain 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0009924
name: obsolete octadecanal decarbonylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb]
comment: This term was obsoleted because it represents a specific substrate of aldehyde decarbonylase activity ; GO:0071771.
synonym: "octadecanal alkane-lyase activity" EXACT []
is_obsolete: true
replaced_by: GO:0071771

[Term]
id: GO:0009925
name: basal plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0009926
name: auxin polar transport
namespace: biological_process
def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm]
is_a: GO:0060918 ! auxin transport

[Term]
id: GO:0009927
name: histidine phosphotransfer kinase activity
namespace: molecular_function
def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140, PMID:31386843]
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0009930
name: longitudinal side of cell surface
namespace: cellular_component
def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0009931
name: calcium-dependent protein serine/threonine kinase activity
namespace: molecular_function
def: "Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah]
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0009932
name: cell tip growth
namespace: biological_process
def: "Growth that occurs specifically at the tip of a cell." [GOC:jid]
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0009933
name: meristem structural organization
namespace: biological_process
def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684]
synonym: "meristem organisation" BROAD []
synonym: "meristem organization" BROAD []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0009934
name: regulation of meristem structural organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jid]
synonym: "regulation of meristem organisation" EXACT []
synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0009933 ! meristem structural organization

[Term]
id: GO:0009935
name: obsolete nutrient import
namespace: biological_process
def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm]
comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning.
synonym: "nutrient import" EXACT []
synonym: "nutrient uptake" EXACT []
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0009936
name: obsolete expansin
namespace: molecular_function
def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "expansin" EXACT []
is_obsolete: true
consider: GO:0009505
consider: GO:0016049

[Term]
id: GO:0009937
name: regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators]
synonym: "regulation of gibberellic acid mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009938
name: negative regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm]
synonym: "down regulation of gibberellic acid mediated signaling" EXACT []
synonym: "down-regulation of gibberellic acid mediated signaling" EXACT []
synonym: "downregulation of gibberellic acid mediated signaling" EXACT []
synonym: "inhibition of gibberellic acid mediated signaling" NARROW []
synonym: "negative regulation of gibberellic acid mediated signalling" EXACT []
is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009939
name: positive regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm]
synonym: "activation of gibberellic acid mediated signaling" NARROW []
synonym: "positive regulation of gibberellic acid mediated signalling" EXACT []
synonym: "stimulation of gibberellic acid mediated signaling" NARROW []
synonym: "up regulation of gibberellic acid mediated signaling" EXACT []
synonym: "up-regulation of gibberellic acid mediated signaling" EXACT []
synonym: "upregulation of gibberellic acid mediated signaling" EXACT []
is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009940
name: amino-terminal vacuolar sorting propeptide binding
namespace: molecular_function
def: "Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles." [GOC:sm, PMID:10871276]
is_a: GO:0010209 ! vacuolar sorting signal binding

[Term]
id: GO:0009941
name: chloroplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0009942
name: longitudinal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb]
synonym: "apical-basal pattern specification" EXACT []
synonym: "longitudinal axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0009943
name: adaxial/abaxial axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb]
synonym: "adaxial/abaxial determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009955 ! adaxial/abaxial pattern specification

[Term]
id: GO:0009944
name: polarity specification of adaxial/abaxial axis
namespace: biological_process
def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009943 ! adaxial/abaxial axis specification

[Term]
id: GO:0009945
name: radial axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009956 ! radial pattern formation

[Term]
id: GO:0009946
name: proximal/distal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "proximal/distal axis determination" RELATED [GOC:dph]
synonym: "proximodistal axis specification" EXACT []
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0009947
name: centrolateral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:dsz, GOC:tb, ISBN:0865427429]
synonym: "centrolateral axis determination" RELATED [GOC:dph]
synonym: "mediolateral axis specification" EXACT []
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0097353 ! centrolateral pattern formation

[Term]
id: GO:0009948
name: anterior/posterior axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "anterior/posterior axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0009949
name: polarity specification of anterior/posterior axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0009950
name: dorsal/ventral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "dorsal/ventral axis determination" RELATED [GOC:dph]
synonym: "dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0009951
name: polarity specification of dorsal/ventral axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah]
synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0009952
name: anterior/posterior pattern specification
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "anterior/posterior pattern formation" RELATED []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009953
name: dorsal/ventral pattern formation
namespace: biological_process
def: "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "dorsal/ventral pattern specification" NARROW []
synonym: "dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009954
name: proximal/distal pattern formation
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "proximal/distal pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009955
name: adaxial/abaxial pattern specification
namespace: biological_process
def: "The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "adaxial/abaxial pattern formation" RELATED []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009956
name: radial pattern formation
namespace: biological_process
def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "radial pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009957
name: epidermal cell fate specification
namespace: biological_process
alt_id: GO:0043356
def: "The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm]
synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0009958
name: positive gravitropism
namespace: biological_process
def: "The orientation of plant parts towards gravity." [GOC:sm]
synonym: "root gravitropism" NARROW []
is_a: GO:0009630 ! gravitropism

[Term]
id: GO:0009959
name: negative gravitropism
namespace: biological_process
def: "The orientation of plant parts away from gravity." [GOC:sm]
synonym: "shoot gravitropism" NARROW []
is_a: GO:0009630 ! gravitropism

[Term]
id: GO:0009960
name: endosperm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0009961
name: response to 1-aminocyclopropane-1-carboxylic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009962
name: regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
synonym: "regulation of flavonoid anabolism" EXACT []
synonym: "regulation of flavonoid biosynthesis" EXACT []
synonym: "regulation of flavonoid formation" EXACT []
synonym: "regulation of flavonoid synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009963
name: positive regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
synonym: "activation of flavonoid biosynthetic process" NARROW []
synonym: "positive regulation of flavonoid anabolism" EXACT []
synonym: "positive regulation of flavonoid biosynthesis" EXACT []
synonym: "positive regulation of flavonoid formation" EXACT []
synonym: "positive regulation of flavonoid synthesis" EXACT []
synonym: "stimulation of flavonoid biosynthetic process" NARROW []
synonym: "up regulation of flavonoid biosynthetic process" EXACT []
synonym: "up-regulation of flavonoid biosynthetic process" EXACT []
synonym: "upregulation of flavonoid biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009964
name: negative regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
synonym: "down regulation of flavonoid biosynthetic process" EXACT []
synonym: "down-regulation of flavonoid biosynthetic process" EXACT []
synonym: "downregulation of flavonoid biosynthetic process" EXACT []
synonym: "inhibition of flavonoid biosynthetic process" NARROW []
synonym: "negative regulation of flavonoid anabolism" EXACT []
synonym: "negative regulation of flavonoid biosynthesis" EXACT []
synonym: "negative regulation of flavonoid formation" EXACT []
synonym: "negative regulation of flavonoid synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009965
name: leaf morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the leaf are generated and organized." [GOC:go_curators]
is_a: GO:1905392 ! plant organ morphogenesis
relationship: part_of GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0009966
name: regulation of signal transduction
namespace: biological_process
alt_id: GO:0035466
def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "regulation of signaling pathway" RELATED []
synonym: "regulation of signalling pathway" RELATED [GOC:mah]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009967
name: positive regulation of signal transduction
namespace: biological_process
alt_id: GO:0035468
def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "activation of signal transduction" NARROW []
synonym: "positive regulation of signaling pathway" RELATED []
synonym: "positive regulation of signalling pathway" RELATED [GOC:mah]
synonym: "stimulation of signal transduction" NARROW []
synonym: "up regulation of signal transduction" EXACT []
synonym: "up-regulation of signal transduction" EXACT []
synonym: "upregulation of signal transduction" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009968
name: negative regulation of signal transduction
namespace: biological_process
alt_id: GO:0035467
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "down regulation of signal transduction" EXACT []
synonym: "down-regulation of signal transduction" EXACT []
synonym: "downregulation of signal transduction" EXACT []
synonym: "inhibition of signal transduction" NARROW []
synonym: "negative regulation of signaling pathway" RELATED []
synonym: "negative regulation of signalling pathway" RELATED [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009969
name: xyloglucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:sm]
synonym: "xyloglucan anabolism" EXACT []
synonym: "xyloglucan biosynthesis" EXACT []
synonym: "xyloglucan formation" EXACT []
synonym: "xyloglucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0010411 ! xyloglucan metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0009970
name: cellular response to sulfate starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm]
synonym: "cellular response to sulphate starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0009971
name: anastral spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272]
is_a: GO:0007053 ! spindle assembly involved in male meiosis
is_a: GO:0055048 ! anastral spindle assembly

[Term]
id: GO:0009972
name: cytidine deamination
namespace: biological_process
def: "The removal of amino group in the presence of water." [GOC:sm]
is_a: GO:0006216 ! cytidine catabolic process

[Term]
id: GO:0009973
name: adenylyl-sulfate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + AMP + 2 H+ + sulfite = adenosine 5'-phosphosulfate + AH2." [PMID:5421934, RHEA:24240]
synonym: "adenosine phosphosulfate reductase activity" RELATED [EC:1.8.99.2]
synonym: "adenylyl-sulphate reductase activity" RELATED [EC:1.8.99.2]
synonym: "APS reductase activity" RELATED [EC:1.8.99.2]
xref: EC:1.8.99.2
xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN
xref: RHEA:24240
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0009974
name: obsolete zeinoxanthin epsilon hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [PMID:8837513]
comment: This term was obsoleted because it represents a specific substrate of carotene epsilon hydroxylase activity ; GO:0072374
is_obsolete: true
replaced_by: GO:0072374

[Term]
id: GO:0009975
name: cyclase activity
namespace: molecular_function
def: "Catalysis of a ring closure reaction." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009976
name: tocopherol cyclase activity
namespace: molecular_function
def: "Catalysis of the reactions: delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol, gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol. delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol gamma-tocotrienol, and = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol." [EC:5.5.1.24, PMID:12213958]
xref: EC:5.5.1.24
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0009977
name: proton motive force dependent protein transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015557
def: "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245, PMID:25494301]
synonym: "arginine targeting transmembrane transporter activity" EXACT []
synonym: "delta-pH-dependent protein transporter activity" EXACT []
synonym: "pH-dependent protein transporter activity" EXACT []
synonym: "twin-arginine targeting transmembrane transporter activity" EXACT []
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0009978
name: allene oxide synthase activity
namespace: molecular_function
alt_id: GO:0047987
def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, PMID:9778849]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" RELATED [EC:4.2.1.92]
synonym: "HPI" RELATED [EC:4.2.1.92]
synonym: "hydroperoxide dehydratase activity" RELATED []
synonym: "hydroperoxide isomerase activity" RELATED [EC:4.2.1.92]
synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92]
synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92]
xref: EC:4.2.1.92
xref: MetaCyc:RXN1F-19
xref: RHEA:25074
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0009979
name: obsolete 16:0 monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah]
comment: This term was obsoleted because it represents the same activity as palmitoyl-[glycerolipid] 7-desaturase activity ; GO:0102843.
is_obsolete: true
replaced_by: GO:0102843

[Term]
id: GO:0009980
name: obsolete glutamate carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11]
synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11]
synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11]
synonym: "glutamate carboxypeptidase activity" EXACT []
synonym: "glutamyl carboxypeptidase activity" RELATED [EC:3.4.17.11]
synonym: "N-pteroyl-L-glutamate hydrolase activity" RELATED [EC:3.4.17.11]
is_obsolete: true
replaced_by: GO:0004180

[Term]
id: GO:0009982
name: pseudouridine synthase activity
namespace: molecular_function
alt_id: GO:0016439
def: "Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]
comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate.
xref: Reactome:R-HSA-6782381 "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs"
xref: Reactome:R-HSA-6786583 "PUS7 transforms uridine to pseudouridine in tRNAs"
xref: Reactome:R-HSA-6787566 "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)"
xref: Reactome:R-HSA-6790905 "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA"
xref: Reactome:R-HSA-8870289 "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA"
xref: RHEA:48348
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0009983
name: obsolete tyrosine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
synonym: "tyrosine aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0009984
name: obsolete adenylate forming enzyme activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835]
comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP.
synonym: "adenylate forming enzyme activity" EXACT []
is_obsolete: true
consider: GO:0046033

[Term]
id: GO:0009985
name: obsolete dihydroflavonol(thiole) lyase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:tb]
comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists.
synonym: "dihydroflavonol(thiole) lyase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0009986
name: cell surface
namespace: cellular_component
alt_id: GO:0009928
alt_id: GO:0009929
def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
subset: goslim_pir
synonym: "cell associated" EXACT []
synonym: "cell bound" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0009987
name: cellular process
namespace: biological_process
alt_id: GO:0008151
alt_id: GO:0044763
alt_id: GO:0050875
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
subset: goslim_plant
synonym: "cell growth and/or maintenance" NARROW []
synonym: "cell physiology" EXACT []
synonym: "cellular physiological process" EXACT []
synonym: "single-organism cellular process" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0009988
name: cell-cell recognition
namespace: biological_process
def: "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820]
is_a: GO:0008037 ! cell recognition

[Term]
id: GO:0009989
name: cell-matrix recognition
namespace: biological_process
def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820]
is_a: GO:0008037 ! cell recognition

[Term]
id: GO:0009990
name: contact guidance
namespace: biological_process
def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820]
is_a: GO:0009989 ! cell-matrix recognition

[Term]
id: GO:0009991
name: obsolete response to extracellular stimulus
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators]
comment: The reason for obsoletion is that this term is too vague.
is_obsolete: true
consider: GO:0051716

[Term]
id: GO:0009992
name: intracellular water homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of water within a cell." [GOC:dph, GOC:tb]
synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb]
synonym: "cellular water homeostasis" EXACT []
is_a: GO:0006884 ! cell volume homeostasis
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0009994
name: oocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
synonym: "oocyte cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0009995
name: soluble molecule recognition
namespace: biological_process
def: "The recognition of soluble molecules in the environment." [GOC:go_curators]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0009996
name: negative regulation of cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators]
synonym: "down regulation of cell fate specification" EXACT []
synonym: "down-regulation of cell fate specification" EXACT []
synonym: "downregulation of cell fate specification" EXACT []
synonym: "inhibition of cell fate specification" NARROW []
synonym: "suppression of cell fate" EXACT []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0042659 ! regulation of cell fate specification
relationship: negatively_regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0009997
name: negative regulation of cardioblast cell fate specification
namespace: biological_process
alt_id: GO:0042687
def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "down regulation of cardioblast cell fate specification" EXACT []
synonym: "down-regulation of cardioblast cell fate specification" EXACT []
synonym: "downregulation of cardioblast cell fate specification" EXACT []
synonym: "inhibition of cardioblast cell fate specification" NARROW []
synonym: "suppression of cardioblast cell fate" EXACT []
is_a: GO:0042686 ! regulation of cardioblast cell fate specification
is_a: GO:0051892 ! negative regulation of cardioblast differentiation
is_a: GO:2000044 ! negative regulation of cardiac cell fate specification
relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification

[Term]
id: GO:0009998
name: negative regulation of retinal cone cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators]
synonym: "down regulation of retinal cone cell fate specification" EXACT []
synonym: "down-regulation of retinal cone cell fate specification" EXACT []
synonym: "downregulation of retinal cone cell fate specification" EXACT []
synonym: "inhibition of retinal cone cell fate specification" NARROW []
synonym: "negative regulation of retina cone cell fate specification" EXACT []
synonym: "suppression of retina cone cell fate" EXACT []
synonym: "suppression of retinal cone cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042673 ! regulation of retinal cone cell fate specification
is_a: GO:0060226 ! negative regulation of retinal cone cell fate commitment
relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification

[Term]
id: GO:0009999
name: negative regulation of auditory receptor cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators]
synonym: "down regulation of auditory receptor cell fate specification" EXACT []
synonym: "down-regulation of auditory receptor cell fate specification" EXACT []
synonym: "downregulation of auditory receptor cell fate specification" EXACT []
synonym: "inhibition of auditory receptor cell fate specification" NARROW []
synonym: "negative regulation of auditory hair cell fate specification" EXACT []
synonym: "suppression of auditory receptor cell fate" EXACT []
synonym: "suppression of hair cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042669 ! regulation of inner ear auditory receptor cell fate specification
is_a: GO:0045608 ! negative regulation of inner ear auditory receptor cell differentiation
relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification

[Term]
id: GO:0010001
name: glial cell differentiation
namespace: biological_process
alt_id: GO:0007404
alt_id: GO:0043360
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
synonym: "glia cell differentiation" EXACT []
synonym: "neuroglia differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0010002
name: cardioblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart]
synonym: "cardioblast cell differentiation" EXACT []
synonym: "cardiomyocyte generation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0048863 ! stem cell differentiation

[Term]
id: GO:0010004
name: gastrulation involving germ band extension
namespace: biological_process
def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001703 ! gastrulation with mouth forming first

[Term]
id: GO:0010005
name: cortical microtubule, transverse to long axis
namespace: cellular_component
def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399]
is_a: GO:0055028 ! cortical microtubule

[Term]
id: GO:0010006
name: Toc complex
namespace: cellular_component
def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010007
name: magnesium chelatase complex
namespace: cellular_component
def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0010008
name: endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endosome." [GOC:mah]
synonym: "endosomal membrane" EXACT [NIF_Subcellular:sao978443756]
xref: NIF_Subcellular:sao978443756
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0010009
name: cytoplasmic side of endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the endosome membrane that faces the cytoplasm." [GOC:lr]
synonym: "external leaflet of endosome membrane" EXACT [GOC:ab]
synonym: "external side of endosome membrane" EXACT []
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0010011
name: auxin binding
namespace: molecular_function
def: "Binding to auxin, a plant hormone that regulates aspects of plant growth." [GOC:sm]
synonym: "auxin receptor" NARROW []
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0010012
name: obsolete steroid 22-alpha hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb]
comment: This term was obsoleted because it represents the same activity as steroid 22S-hydroxylase activity; GO:0160191.
is_obsolete: true
replaced_by: GO:0160191

[Term]
id: GO:0010013
name: N-1-naphthylphthalamic acid binding
namespace: molecular_function
def: "Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm]
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0010014
name: meristem initiation
namespace: biological_process
def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009933 ! meristem structural organization

[Term]
id: GO:0010015
name: root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099]
is_a: GO:1905392 ! plant organ morphogenesis
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010016
name: shoot system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099]
synonym: "shoot morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0010017
name: red or far-red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm]
synonym: "phytochrome signaling pathway" BROAD []
synonym: "red or far red light signaling pathway" EXACT [GOC:bf, GOC:tb]
synonym: "red or far-red light signal transduction" EXACT [GOC:signaling]
synonym: "red or far-red light signalling pathway" EXACT []
synonym: "red/far red light signaling pathway" EXACT []
is_a: GO:0007165 ! signal transduction
is_a: GO:0071489 ! cellular response to red or far red light

[Term]
id: GO:0010018
name: far-red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm]
synonym: "far red light signalling pathway" EXACT []
synonym: "far red signaling pathway" EXACT [GOC:tb]
synonym: "far-red light signal transduction" EXACT [GOC:signaling]
is_a: GO:0010017 ! red or far-red light signaling pathway
is_a: GO:0071490 ! cellular response to far red light

[Term]
id: GO:0010019
name: chloroplast-nucleus signaling pathway
namespace: biological_process
def: "The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595]
synonym: "chloroplast-nucleus signalling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0010020
name: chloroplast fission
namespace: biological_process
def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr]
synonym: "chloroplast division" EXACT []
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0043572 ! plastid fission

[Term]
id: GO:0010021
name: amylopectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages." [ISBN:0943088399]
synonym: "amylopectin anabolism" EXACT []
synonym: "amylopectin biosynthesis" EXACT []
synonym: "amylopectin formation" EXACT []
synonym: "amylopectin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:2000896 ! amylopectin metabolic process

[Term]
id: GO:0010022
name: meristem determinacy
namespace: biological_process
def: "The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0010073 ! meristem maintenance

[Term]
id: GO:0010023
name: proanthocyanidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm]
synonym: "proanthocyanidin anabolism" EXACT []
synonym: "proanthocyanidin biosynthesis" EXACT []
synonym: "proanthocyanidin formation" EXACT []
synonym: "proanthocyanidin synthesis" EXACT []
xref: MetaCyc:PWY-641
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0010024
name: phytochromobilin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195]
synonym: "phytochromobilin anabolism" EXACT []
synonym: "phytochromobilin biosynthesis" EXACT []
synonym: "phytochromobilin formation" EXACT []
synonym: "phytochromobilin synthesis" EXACT []
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0051202 ! phytochromobilin metabolic process

[Term]
id: GO:0010025
name: wax biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399]
synonym: "wax anabolism" EXACT []
synonym: "wax biosynthesis" EXACT []
synonym: "wax formation" EXACT []
synonym: "wax synthesis" EXACT []
xref: MetaCyc:PWY-282
is_a: GO:0010166 ! wax metabolic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process

[Term]
id: GO:0010026
name: trichome differentiation
namespace: biological_process
alt_id: GO:0048271
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433]
synonym: "trichome cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0090558 ! plant epidermis development

[Term]
id: GO:0010027
name: thylakoid membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb]
comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'.
synonym: "thylakoid membrane organisation" EXACT []
synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0010028
name: xanthophyll cycle
namespace: biological_process
def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743]
xref: MetaCyc:PWY-5945
xref: Wikipedia:Xanthophyll#Xanthophyll_cycle
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0010029
name: regulation of seed germination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm]
is_a: GO:1900140 ! regulation of seedling development
relationship: regulates GO:0009845 ! seed germination

[Term]
id: GO:0010030
name: positive regulation of seed germination
namespace: biological_process
def: "Any process that activates or increase the rate of seed germination." [GOC:sm]
synonym: "activation of seed germination" NARROW []
synonym: "stimulation of seed germination" NARROW []
synonym: "up regulation of seed germination" EXACT []
synonym: "up-regulation of seed germination" EXACT []
synonym: "upregulation of seed germination" EXACT []
is_a: GO:0010029 ! regulation of seed germination
is_a: GO:0048582 ! positive regulation of post-embryonic development
relationship: positively_regulates GO:0009845 ! seed germination

[Term]
id: GO:0010031
name: circumnutation
namespace: biological_process
def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023]
is_a: GO:0050879 ! multicellular organismal movement

[Term]
id: GO:0010032
name: meiotic chromosome condensation
namespace: biological_process
def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401]
synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030261 ! chromosome condensation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle

[Term]
id: GO:0010033
name: obsolete response to organic substance
namespace: biological_process
alt_id: GO:1990367
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.\nThe reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "process resulting in tolerance to organic substance" NARROW []
is_obsolete: true

[Term]
id: GO:0010034
name: response to acetate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010035
name: obsolete response to inorganic substance
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0010036
name: response to boron-containing substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus." [GOC:sm]
synonym: "response to boron" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0010037
name: response to carbon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010038
name: response to metal ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]
synonym: "heavy metal sensitivity/resistance" RELATED []
synonym: "response to heavy metal" NARROW []
synonym: "response to metal" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0010039
name: response to iron ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm]
synonym: "response to iron" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010040
name: response to iron(II) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm]
synonym: "response to iron(II)" EXACT []
is_a: GO:0010039 ! response to iron ion

[Term]
id: GO:0010041
name: response to iron(III) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm]
synonym: "response to iron(III)" EXACT []
is_a: GO:0010039 ! response to iron ion

[Term]
id: GO:0010042
name: response to manganese ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm]
synonym: "response to manganese" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010043
name: response to zinc ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]
synonym: "response to zinc" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010044
name: response to aluminum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm]
synonym: "response to aluminium ion" EXACT []
synonym: "response to aluminum" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010045
name: response to nickel cation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus." [GOC:sm]
synonym: "response to nickel" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010046
name: response to mycotoxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:sm]
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0010047
name: fruit dehiscence
namespace: biological_process
def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208]
is_a: GO:0009900 ! dehiscence

[Term]
id: GO:0010048
name: vernalization response
namespace: biological_process
def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392]
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0010049
name: acquisition of plant reproductive competence
namespace: biological_process
def: "The process in which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators]
synonym: "acquisition of reproductive competence" BROAD []
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0010050
name: vegetative phase change
namespace: biological_process
def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0010051
name: xylem and phloem pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "vascular tissue pattern formation" EXACT []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0010052
name: guard cell differentiation
namespace: biological_process
def: "The process in which a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb]
synonym: "stomatal cell differentiation" RELATED []
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0010103 ! stomatal complex morphogenesis

[Term]
id: GO:0010053
name: root epidermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb]
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0010015 ! root morphogenesis
relationship: part_of GO:0090558 ! plant epidermis development

[Term]
id: GO:0010054
name: trichoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb]
synonym: "trichoblast cell differentiation" EXACT []
is_a: GO:0010053 ! root epidermal cell differentiation

[Term]
id: GO:0010055
name: atrichoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb]
is_a: GO:0010053 ! root epidermal cell differentiation

[Term]
id: GO:0010056
name: atrichoblast fate specification
namespace: biological_process
def: "The process involved in the specification of an atrichoblast." [GOC:tb]
is_a: GO:0090628 ! plant epidermal cell fate specification
relationship: part_of GO:0010055 ! atrichoblast differentiation

[Term]
id: GO:0010057
name: trichoblast fate specification
namespace: biological_process
def: "The process involved in the specification of a trichoblast." [GOC:tb]
is_a: GO:0090628 ! plant epidermal cell fate specification
relationship: part_of GO:0010054 ! trichoblast differentiation

[Term]
id: GO:0010058
name: regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that modulates atrichoblast fate specification." [GOC:tb]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
relationship: regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010059
name: positive regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb]
synonym: "activation of atrichoblast fate" NARROW []
synonym: "stimulation of atrichoblast fate" NARROW []
synonym: "up regulation of atrichoblast fate" EXACT []
synonym: "up-regulation of atrichoblast fate" EXACT []
synonym: "upregulation of atrichoblast fate" EXACT []
is_a: GO:0010058 ! regulation of atrichoblast fate specification
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation
relationship: positively_regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010060
name: negative regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that suppresses atrichoblast fate specification." [GOC:tb]
synonym: "down regulation of atrichoblast fate" EXACT []
synonym: "down-regulation of atrichoblast fate" EXACT []
synonym: "downregulation of atrichoblast fate" EXACT []
synonym: "inhibition of atrichoblast fate" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0010058 ! regulation of atrichoblast fate specification
is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation
relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010061
name: regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that modulates trichoblast fate specification." [GOC:tb]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
is_a: GO:2000067 ! regulation of root morphogenesis
relationship: regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010062
name: negative regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that suppresses trichoblast fate specification." [GOC:tb]
synonym: "down regulation of trichoblast fate" EXACT []
synonym: "down-regulation of trichoblast fate" EXACT []
synonym: "downregulation of trichoblast fate" EXACT []
synonym: "inhibition of trichoblast fate" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0010061 ! regulation of trichoblast fate specification
is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation
relationship: negatively_regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010063
name: positive regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb]
synonym: "activation of trichoblast fate" NARROW []
synonym: "stimulation of trichoblast fate" NARROW []
synonym: "up regulation of trichoblast fate" EXACT []
synonym: "up-regulation of trichoblast fate" EXACT []
synonym: "upregulation of trichoblast fate" EXACT []
is_a: GO:0010061 ! regulation of trichoblast fate specification
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation
relationship: positively_regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010064
name: embryonic shoot morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of embryonic shoot are generated and organized." [GOC:tb]
synonym: "primary shoot system morphogenesis" EXACT []
is_a: GO:0010016 ! shoot system morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010065
name: primary meristem tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208]
synonym: "primary meristem histogenesis" EXACT []
is_a: GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010066
name: ground meristem histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010067
name: procambium histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010068
name: protoderm histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010069
name: zygote asymmetric cytokinesis in embryo sac
namespace: biological_process
def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429]
is_a: GO:0000281 ! mitotic cytokinesis
is_a: GO:0010070 ! zygote asymmetric cell division
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0010070
name: zygote asymmetric cell division
namespace: biological_process
def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb]
synonym: "zygote asymmetric cytokinesis" RELATED []
is_a: GO:0008356 ! asymmetric cell division

[Term]
id: GO:0010071
name: root meristem specification
namespace: biological_process
def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090421 ! embryonic meristem initiation
relationship: part_of GO:0010015 ! root morphogenesis
relationship: part_of GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010072
name: primary shoot apical meristem specification
namespace: biological_process
def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb]
synonym: "embryo shoot apical meristem specification" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090421 ! embryonic meristem initiation
relationship: part_of GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010073
name: meristem maintenance
namespace: biological_process
def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0010074
name: maintenance of meristem identity
namespace: biological_process
alt_id: GO:0032503
def: "The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb]
synonym: "maintenance of meristem cell identity" EXACT []
synonym: "meristem cell maintenance" EXACT []
is_a: GO:0019827 ! stem cell population maintenance
relationship: part_of GO:0010073 ! meristem maintenance

[Term]
id: GO:0010075
name: regulation of meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb]
synonym: "regulation of meristem size" EXACT [GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
relationship: part_of GO:0010073 ! meristem maintenance
relationship: regulates GO:0035266 ! meristem growth

[Term]
id: GO:0010076
name: maintenance of floral meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010077
name: maintenance of inflorescence meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010078
name: maintenance of root meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity
relationship: part_of GO:0010015 ! root morphogenesis

[Term]
id: GO:0010079
name: maintenance of vegetative meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010080
name: regulation of floral meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb]
synonym: "regulation of floral meristem size" EXACT []
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0010451 ! floral meristem growth

[Term]
id: GO:0010081
name: regulation of inflorescence meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb]
synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0010450 ! inflorescence meristem growth

[Term]
id: GO:0010082
name: regulation of root meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb]
synonym: "regulation of root meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
relationship: part_of GO:0010015 ! root morphogenesis
relationship: regulates GO:0010449 ! root meristem growth

[Term]
id: GO:0010083
name: regulation of vegetative meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb]
synonym: "regulation of vegetative meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:1905613 ! regulation of developmental vegetative growth
relationship: regulates GO:0010448 ! vegetative meristem growth

[Term]
id: GO:0010084
name: specification of animal organ axis polarity
namespace: biological_process
def: "The process in which the polarity of an animal organ axis is specified." [GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0010085
name: polarity specification of proximal/distal axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009946 ! proximal/distal axis specification

[Term]
id: GO:0010086
name: embryonic root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic root are generated and organized." [GOC:tb]
is_a: GO:0010015 ! root morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010087
name: phloem or xylem histogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "vascular tissue development" BROAD []
synonym: "vascular tissue histogenesis" EXACT []
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0010088
name: phloem development
namespace: biological_process
def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208]
synonym: "phloem histogenesis" EXACT [GOC:tb]
is_a: GO:0010087 ! phloem or xylem histogenesis

[Term]
id: GO:0010089
name: xylem development
namespace: biological_process
def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208]
synonym: "xylem histogenesis" EXACT [GOC:tb]
is_a: GO:0010087 ! phloem or xylem histogenesis

[Term]
id: GO:0010090
name: trichome morphogenesis
namespace: biological_process
alt_id: GO:0048272
def: "The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators]
synonym: "trichome cell morphogenesis during differentiation" EXACT []
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0010026 ! trichome differentiation
relationship: part_of GO:0090626 ! plant epidermis morphogenesis

[Term]
id: GO:0010091
name: trichome branching
namespace: biological_process
alt_id: GO:0048274
def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0010090 ! trichome morphogenesis

[Term]
id: GO:0010092
name: specification of animal organ identity
namespace: biological_process
def: "The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0048645 ! animal organ formation

[Term]
id: GO:0010093
name: specification of floral organ identity
namespace: biological_process
def: "The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090701 ! specification of plant organ identity
relationship: part_of GO:0048449 ! floral organ formation

[Term]
id: GO:0010094
name: specification of carpel identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048462 ! carpel formation

[Term]
id: GO:0010095
name: specification of petal identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048451 ! petal formation

[Term]
id: GO:0010096
name: specification of sepal identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048453 ! sepal formation

[Term]
id: GO:0010097
name: specification of stamen identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048455 ! stamen formation

[Term]
id: GO:0010098
name: suspensor development
namespace: biological_process
def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0010099
name: regulation of photomorphogenesis
namespace: biological_process
def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:2000030 ! regulation of response to red or far red light
relationship: regulates GO:0009640 ! photomorphogenesis

[Term]
id: GO:0010100
name: negative regulation of photomorphogenesis
namespace: biological_process
def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb]
synonym: "down regulation of photomorphogenesis" EXACT []
synonym: "down-regulation of photomorphogenesis" EXACT []
synonym: "downregulation of photomorphogenesis" EXACT []
synonym: "inhibition of photomorphogenesis" NARROW []
is_a: GO:0010099 ! regulation of photomorphogenesis
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009640 ! photomorphogenesis

[Term]
id: GO:0010101
name: post-embryonic root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb]
is_a: GO:0010015 ! root morphogenesis
is_a: GO:0090697 ! post-embryonic plant organ morphogenesis
relationship: part_of GO:0048528 ! post-embryonic root development

[Term]
id: GO:0010102
name: lateral root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators]
is_a: GO:0010101 ! post-embryonic root morphogenesis
relationship: part_of GO:0048527 ! lateral root development

[Term]
id: GO:0010103
name: stomatal complex morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators]
is_a: GO:0090626 ! plant epidermis morphogenesis
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0010374 ! stomatal complex development

[Term]
id: GO:0010104
name: regulation of ethylene-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction." [GOC:tb]
synonym: "regulation of ethene mediated signaling pathway" EXACT []
synonym: "regulation of ethene mediated signalling pathway" EXACT []
synonym: "regulation of ethylene mediated signaling pathway" RELATED []
synonym: "regulation of ethylene mediated signalling pathway" EXACT []
is_a: GO:0070297 ! regulation of phosphorelay signal transduction system
relationship: regulates GO:0009873 ! ethylene-activated signaling pathway

[Term]
id: GO:0010105
name: negative regulation of ethylene-activated signaling pathway
namespace: biological_process
def: "Any process that stops or prevents ethylene (ethene) signal transduction." [GOC:tb]
synonym: "down regulation of ethylene mediated signaling pathway" EXACT []
synonym: "down-regulation of ethylene mediated signaling pathway" EXACT []
synonym: "downregulation of ethylene mediated signaling pathway" EXACT []
synonym: "inhibition of ethylene mediated signaling pathway" NARROW []
synonym: "negative regulation of ethene mediated signaling pathway" EXACT []
synonym: "negative regulation of ethene mediated signalling pathway" EXACT []
synonym: "negative regulation of ethylene mediated signaling pathway" RELATED []
synonym: "negative regulation of ethylene mediated signalling pathway" EXACT []
is_a: GO:0010104 ! regulation of ethylene-activated signaling pathway
is_a: GO:0070298 ! negative regulation of phosphorelay signal transduction system
relationship: negatively_regulates GO:0009873 ! ethylene-activated signaling pathway

[Term]
id: GO:0010106
name: cellular response to iron ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg]
is_a: GO:0009267 ! cellular response to starvation
relationship: part_of GO:0006879 ! intracellular iron ion homeostasis

[Term]
id: GO:0010108
name: obsolete detection of glutamine
namespace: biological_process
def: "OBSOLETE. The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
comment: This term was made obsolete because it represents a molecular function GO:0140786 glutamine sensor activity.
synonym: "glutamine detection" EXACT []
synonym: "glutamine perception" RELATED []
synonym: "glutamine sensing" RELATED []
is_obsolete: true
consider: GO:0140786

[Term]
id: GO:0010109
name: regulation of photosynthesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0015979 ! photosynthesis

[Term]
id: GO:0010110
name: regulation of photosynthesis, dark reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0019685 ! photosynthesis, dark reaction

[Term]
id: GO:0010111
name: glyoxysome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb]
synonym: "glyoxysome organisation" EXACT []
synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0010112
name: regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0010113
name: negative regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm]
synonym: "down regulation of systemic acquired resistance" EXACT []
synonym: "down-regulation of systemic acquired resistance" EXACT []
synonym: "downregulation of systemic acquired resistance" EXACT []
synonym: "inhibition of systemic acquired resistance" NARROW []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
relationship: negatively_regulates GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0010114
name: response to red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm]
synonym: "response to red light stimulus" EXACT []
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0010115
name: regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm]
synonym: "regulation of abscisic acid anabolism" EXACT []
synonym: "regulation of abscisic acid biosynthesis" EXACT []
synonym: "regulation of abscisic acid formation" EXACT []
synonym: "regulation of abscisic acid synthesis" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0009688 ! abscisic acid biosynthetic process

[Term]
id: GO:0010116
name: positive regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm]
synonym: "activation of abscisic acid biosynthetic process" NARROW []
synonym: "positive regulation of abscisic acid anabolism" EXACT []
synonym: "positive regulation of abscisic acid biosynthesis" EXACT []
synonym: "positive regulation of abscisic acid formation" EXACT []
synonym: "positive regulation of abscisic acid synthesis" EXACT []
synonym: "stimulation of abscisic acid biosynthetic process" NARROW []
synonym: "up regulation of abscisic acid biosynthetic process" EXACT []
synonym: "up-regulation of abscisic acid biosynthetic process" EXACT []
synonym: "upregulation of abscisic acid biosynthetic process" EXACT []
is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process

[Term]
id: GO:0010117
name: photoprotection
namespace: biological_process
def: "Protection mechanism used by plants and cyanobacteria under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [PMID:30765616]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0010118
name: stomatal movement
namespace: biological_process
def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0010119
name: regulation of stomatal movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0010118 ! stomatal movement

[Term]
id: GO:0010120
name: camalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz]
synonym: "camalexin anabolism" EXACT []
synonym: "camalexin biosynthesis" EXACT []
synonym: "camalexin formation" EXACT []
synonym: "camalexin synthesis" EXACT []
xref: MetaCyc:CAMALEXIN-SYN
is_a: GO:0009700 ! indole phytoalexin biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0052317 ! camalexin metabolic process

[Term]
id: GO:0010121
name: arginine catabolic process to proline via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz]
synonym: "arginine breakdown to proline via ornithine" EXACT []
synonym: "arginine degradation to proline via ornithine" EXACT []
is_a: GO:0019493 ! arginine catabolic process to proline

[Term]
id: GO:0010122
name: arginine catabolic process to alanine via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz]
synonym: "arginine breakdown to alanine via ornithine" EXACT []
synonym: "arginine degradation to alanine via ornithine" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0010123
name: obsolete acetate catabolic process to butyrate, ethanol, acetone and butanol
namespace: biological_process
def: "OBSOLETE. The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz]
comment: This term was obsoleted because it is not believed to exist.
synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT []
is_obsolete: true
consider: GO:0044813

[Term]
id: GO:0010124
name: phenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz]
synonym: "phenylacetate breakdown" EXACT []
synonym: "phenylacetate catabolism" EXACT []
synonym: "phenylacetate degradation" EXACT []
xref: MetaCyc:PWY0-321
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0010125
name: mycothiol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz]
synonym: "mycothiol anabolism" EXACT []
synonym: "mycothiol biosynthesis" EXACT []
synonym: "mycothiol formation" EXACT []
synonym: "mycothiol synthesis" EXACT []
xref: MetaCyc:PWY1G-0
is_a: GO:0010126 ! mycothiol metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0010126
name: mycothiol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz]
synonym: "mycothiol metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0010127
name: mycothiol-dependent detoxification
namespace: biological_process
def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz]
synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW []
is_a: GO:0098754 ! detoxification

[Term]
id: GO:0010128
name: benzoate catabolic process via CoA ligation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz]
synonym: "anaerobic benzoate breakdown" EXACT []
synonym: "anaerobic benzoate catabolic process" EXACT []
synonym: "anaerobic benzoate catabolism" EXACT []
synonym: "anaerobic benzoate degradation" EXACT []
xref: MetaCyc:PWY-283
is_a: GO:0018875 ! anaerobic benzoate metabolic process
is_a: GO:0043639 ! benzoate catabolic process

[Term]
id: GO:0010129
name: anaerobic cyclohexane-1-carboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz]
synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT []
synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT []
synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT []
xref: MetaCyc:PWY-301
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0010130
name: anaerobic ethylbenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz]
synonym: "anaerobic ethylbenzene breakdown" EXACT []
synonym: "anaerobic ethylbenzene catabolism" EXACT []
synonym: "anaerobic ethylbenzene degradation" EXACT []
xref: MetaCyc:PWY-481
xref: UM-BBD_pathwayID:ethb
is_a: GO:0018915 ! ethylbenzene catabolic process

[Term]
id: GO:0010131
name: obsolete sucrose catabolic process, using invertase or sucrose synthase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz]
comment: This term was made obsolete because it describes two different routes of sucrose catabolism, both of which are represented by molecular functions.
synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT []
synonym: "sucrose catabolic process, using invertase or sucrose synthase" EXACT []
synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT []
synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT []
is_obsolete: true
consider: GO:0004564
consider: GO:0005987
consider: GO:0016157

[Term]
id: GO:0010132
name: dhurrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz]
synonym: "dhurrin anabolism" EXACT []
synonym: "dhurrin biosynthesis" EXACT []
synonym: "dhurrin formation" EXACT []
synonym: "dhurrin synthesis" EXACT []
xref: MetaCyc:PWY-861
is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0010133
name: proline catabolic process to glutamate
namespace: biological_process
alt_id: GO:0019494
def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]
synonym: "proline breakdown to glutamate" EXACT []
synonym: "proline degradation to glutamate" EXACT []
synonym: "proline oxidation" RELATED []
xref: MetaCyc:PROUT-PWY
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006562 ! proline catabolic process

[Term]
id: GO:0010134
name: sulfate assimilation via adenylyl sulfate reduction
namespace: biological_process
def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [MetaCyc:SULFMETII-PWY]
synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT []
xref: MetaCyc:SULFMETII-PWY
is_a: GO:0000103 ! sulfate assimilation

[Term]
id: GO:0010135
name: ureide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz]
synonym: "ureide metabolism" EXACT []
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0010136
name: ureide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz]
synonym: "ureide breakdown" EXACT []
synonym: "ureide catabolism" EXACT []
synonym: "ureide degradation" EXACT []
xref: MetaCyc:URDEGR-PWY
is_a: GO:0009056 ! catabolic process
is_a: GO:0010135 ! ureide metabolic process

[Term]
id: GO:0010137
name: ureide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz]
synonym: "ureide anabolism" EXACT []
synonym: "ureide biosynthesis" EXACT []
synonym: "ureide formation" EXACT []
synonym: "ureide synthesis" EXACT []
is_a: GO:0010135 ! ureide metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0010138
name: pyrimidine ribonucleotide salvage
namespace: biological_process
def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz]
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0032262 ! pyrimidine nucleotide salvage

[Term]
id: GO:0010139
name: pyrimidine deoxyribonucleotide salvage
namespace: biological_process
def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz]
xref: MetaCyc:PWY-7199
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0032262 ! pyrimidine nucleotide salvage

[Term]
id: GO:0010140
name: obsolete adenine, hypoxanthine and their nucleoside salvage
namespace: biological_process
def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz]
comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology.
synonym: "adenine, hypoxanthine and their nucleoside salvage" EXACT []
is_obsolete: true
consider: GO:0006168
consider: GO:0006169
consider: GO:0006190
consider: GO:0043103

[Term]
id: GO:0010141
name: obsolete guanine, xanthine and their nucleoside salvage
namespace: biological_process
def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz]
comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology.
synonym: "guanine, xanthine and their nucleoside salvage" EXACT []
is_obsolete: true
consider: GO:0006178
consider: GO:0006179
consider: GO:0006190
consider: GO:0043103

[Term]
id: GO:0010142
name: farnesyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922]
synonym: "Ac-MVA pathway" NARROW [PMID:14517367]
synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367]
synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT []
synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT []
synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT []
synonym: "isoprenoid pathway" EXACT []
is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process
is_a: GO:1902767 ! isoprenoid biosynthetic process via mevalonate

[Term]
id: GO:0010143
name: cutin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819]
synonym: "cutin anabolism" EXACT []
synonym: "cutin biosynthesis" EXACT []
synonym: "cutin formation" EXACT []
synonym: "cutin synthesis" EXACT []
xref: MetaCyc:PWY-321
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0160062 ! cutin-based cuticle development

[Term]
id: GO:0010144
name: pyridoxal phosphate biosynthetic process from pyridoxamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz]
synonym: "pyridoxal 5'-phosphate salvage from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT []
synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT []
synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT []
is_a: GO:0009443 ! pyridoxal 5'-phosphate salvage
is_a: GO:0042818 ! pyridoxamine metabolic process

[Term]
id: GO:0010145
name: fructan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm]
synonym: "fructan metabolism" EXACT []
synonym: "levan metabolic process" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0010146
name: fructan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz]
synonym: "fructan anabolism" EXACT []
synonym: "fructan biosynthesis" EXACT []
synonym: "fructan formation" EXACT []
synonym: "fructan synthesis" EXACT []
synonym: "levan biosynthesis" EXACT []
synonym: "levan biosynthetic process" EXACT []
xref: MetaCyc:PWY-822
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0010145 ! fructan metabolic process

[Term]
id: GO:0010147
name: fructan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz]
synonym: "fructan breakdown" EXACT []
synonym: "fructan catabolism" EXACT []
synonym: "fructan degradation" EXACT []
synonym: "levan catabolic process" EXACT []
synonym: "levan catabolism" EXACT []
xref: MetaCyc:PWY-862
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010145 ! fructan metabolic process

[Term]
id: GO:0010148
name: transpiration
namespace: biological_process
def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322]
xref: Wikipedia:Transpiration
is_a: GO:0006833 ! water transport

[Term]
id: GO:0010149
name: obsolete senescence
namespace: biological_process
def: "OBSOLETE. A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819]
comment: This term was made obsolete because its name is ambiguous and it is covered by more specific terms: 'plant organ senescence ; GO:0090693' and 'cellular senescence ; GO:0090398'.
synonym: "senescence" EXACT []
xref: Wikipedia:Senescence
is_obsolete: true

[Term]
id: GO:0010150
name: leaf senescence
namespace: biological_process
def: "The last stage of leaf development during which programmed degradation of macromolecules and nutrient recycling take place." [ISBN:0387987819, PMID:17177638, PMID:34938309]
is_a: GO:0090693 ! plant organ senescence
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0010151
name: chloroplast elongation
namespace: biological_process
def: "Expansion of the chloroplast that usually precedes division." [GOC:lr]
is_a: GO:0009658 ! chloroplast organization

[Term]
id: GO:0010152
name: pollen maturation
namespace: biological_process
def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0010153
name: obsolete polar cell elongation
namespace: biological_process
def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864]
comment: This term was made obsolete because it did not represent a process discrete from its sibling terms.
synonym: "polar cell elongation" EXACT []
synonym: "polarity-dependent cell elongation" NARROW []
is_obsolete: true
consider: GO:0042814
consider: GO:0042815

[Term]
id: GO:0010154
name: fruit development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm]
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0010155
name: regulation of proton transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm]
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: regulates GO:1902600 ! proton transmembrane transport

[Term]
id: GO:0010156
name: obsolete sporocyte morphogenesis
namespace: biological_process
def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788]
comment: This term was made obsolete because it was incorrectly defined.
synonym: "sporocyte morphogenesis" EXACT []
is_obsolete: true
consider: GO:0048533

[Term]
id: GO:0010157
name: response to chlorate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010158
name: abaxial cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg]
is_a: GO:0001708 ! cell fate specification

[Term]
id: GO:0010159
name: specification of animal organ position
namespace: biological_process
def: "The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ." [GOC:curators]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0010160
name: formation of animal organ boundary
namespace: biological_process
alt_id: GO:0048862
def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175]
synonym: "organ boundary specification" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0048645 ! animal organ formation

[Term]
id: GO:0010161
name: red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm]
synonym: "red light phototransduction" EXACT [GOC:signaling]
synonym: "red light signal transduction" EXACT [GOC:signaling]
synonym: "red light signalling pathway" EXACT []
is_a: GO:0010017 ! red or far-red light signaling pathway
is_a: GO:0071491 ! cellular response to red light

[Term]
id: GO:0010162
name: seed dormancy process
namespace: biological_process
def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors." [GOC:lr, GOC:PO_curators, ISBN:9781405139830, PO_REF:00009]
synonym: "seed dormancy" RELATED []
xref: Wikipedia:Seed#Seed_dormancy_and_protection
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022611 ! dormancy process
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0010431 ! seed maturation

[Term]
id: GO:0010164
name: response to cesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm]
synonym: "response to cesium" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010165
name: response to X-ray
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray]
synonym: "response to X-ray radiation stimulus" EXACT []
is_a: GO:0010212 ! response to ionizing radiation

[Term]
id: GO:0010166
name: wax metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm]
synonym: "wax metabolism" EXACT []
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:0010167
name: response to nitrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010168
name: ER body
namespace: cellular_component
def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182]
synonym: "endoplasmic reticulum body" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0010169
name: thioglucosidase complex
namespace: cellular_component
def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349]
synonym: "myrosinase complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0010170
name: glucose-1-phosphate adenylyltransferase complex
namespace: cellular_component
def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902503 ! adenylyltransferase complex

[Term]
id: GO:0010171
name: body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0010172
name: embryonic body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic soma are generated and organized." [GOC:ems]
is_a: GO:0010171 ! body morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010174
name: nucleoside transmembrane transporter activity, against a concentration gradient
namespace: molecular_function
def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb]
synonym: "concentrative nucleoside transporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0010176
name: homogentisate phytyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521]
synonym: "HPT activity" EXACT [EC:2.5.1.115]
xref: EC:2.5.1.115
xref: KEGG_REACTION:R07500
xref: MetaCyc:RXN-2541
xref: RHEA:37975
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010177
name: methylthioalkylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H+." [RHEA:50624]
synonym: "2-(2'-methylthio)ethylmalate synthase activity" NARROW []
xref: EC:2.3.3.17
xref: MetaCyc:RXN-18197
xref: RHEA:50624
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0010178
name: IAA-amino acid conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb]
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0010179
name: IAA-Ala conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine." [MetaCyc:RXN-2981]
xref: MetaCyc:RXN-2981
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010180
name: thioglucosidase binding
namespace: molecular_function
def: "Binding to a thioglucosidase enzyme." [GOC:tb]
synonym: "myrosinase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0010181
name: FMN binding
namespace: molecular_function
def: "Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
synonym: "flavin mononucleotide binding" EXACT []
is_a: GO:0032553 ! ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0010182
name: sugar mediated signaling pathway
namespace: biological_process
def: "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361]
synonym: "sugar mediated signalling" EXACT []
is_a: GO:0009756 ! carbohydrate mediated signaling

[Term]
id: GO:0010183
name: pollen tube guidance
namespace: biological_process
def: "The process in which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0010184
name: cytokinin transport
namespace: biological_process
def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:lr]
is_a: GO:0009914 ! hormone transport

[Term]
id: GO:0010185
name: regulation of cellular defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm]
synonym: "regulation of cellular defence response" EXACT []
is_a: GO:0031347 ! regulation of defense response
relationship: regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0010186
name: positive regulation of cellular defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm]
synonym: "activation of cellular defense response" NARROW []
synonym: "positive regulation of cellular defence response" EXACT []
synonym: "stimulation of cellular defense response" NARROW []
synonym: "up regulation of cellular defense response" EXACT []
synonym: "up-regulation of cellular defense response" EXACT []
synonym: "upregulation of cellular defense response" EXACT []
is_a: GO:0010185 ! regulation of cellular defense response
is_a: GO:0031349 ! positive regulation of defense response
relationship: positively_regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0010187
name: negative regulation of seed germination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination." [GOC:tb]
synonym: "down regulation of seed germination" EXACT []
synonym: "down-regulation of seed germination" EXACT []
synonym: "downregulation of seed germination" EXACT []
synonym: "inhibition of seed germination" NARROW []
is_a: GO:0010029 ! regulation of seed germination
is_a: GO:0048581 ! negative regulation of post-embryonic development
relationship: negatively_regulates GO:0009845 ! seed germination

[Term]
id: GO:0010188
name: response to microbial phytotoxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm]
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0010189
name: vitamin E biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg]
synonym: "alpha-tocopherol biosynthesis" NARROW []
synonym: "alpha-tocopherol biosynthetic process" NARROW []
synonym: "tocopherol biosynthesis" EXACT []
synonym: "tocopherol biosynthetic process" EXACT []
synonym: "vitamin E anabolism" EXACT []
synonym: "vitamin E biosynthesis" EXACT []
synonym: "vitamin E formation" EXACT []
synonym: "vitamin E synthesis" EXACT []
xref: MetaCyc:PWY-1422
is_a: GO:0042360 ! vitamin E metabolic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0010190
name: cytochrome b6f complex assembly
namespace: biological_process
def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb]
synonym: "cytochrome b6f complex biogenesis" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0010191
name: mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm]
subset: goslim_pir
synonym: "mucilage metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0010192
name: mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm]
synonym: "mucilage anabolism" EXACT []
synonym: "mucilage biosynthesis" EXACT []
synonym: "mucilage formation" EXACT []
synonym: "mucilage synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0010193
name: response to ozone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm]
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0010194
name: obsolete microRNA metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm]
comment: This term was made obsolete because it implies further processing of an end product rather than its production.
synonym: "microRNA metabolic process" EXACT []
is_obsolete: true
replaced_by: GO:0035196

[Term]
id: GO:0010195
name: obsolete microRNA biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm]
comment: This term was made obsolete because it represents a process that is not known to occur.
synonym: "microRNA anabolism" EXACT []
synonym: "microRNA biosynthesis" EXACT []
synonym: "microRNA biosynthetic process" EXACT []
synonym: "microRNA formation" EXACT []
synonym: "microRNA synthesis" EXACT []
synonym: "miRNA biosynthesis" EXACT []
synonym: "miRNA biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0035196

[Term]
id: GO:0010196
name: nonphotochemical quenching
namespace: biological_process
def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783, PMID:10938857]
is_a: GO:1990066 ! energy quenching

[Term]
id: GO:0010197
name: polar nucleus fusion
namespace: biological_process
def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm]
is_a: GO:0000741 ! karyogamy
relationship: part_of GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0010198
name: synergid death
namespace: biological_process
alt_id: GO:0048470
def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516]
synonym: "synergid cell death" EXACT []
synonym: "synergid degeneration" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! programmed cell death involved in cell development
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0010199
name: organ boundary specification between lateral organs and the meristem
namespace: biological_process
def: "The process in which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116]
is_a: GO:0090691 ! formation of plant organ boundary

[Term]
id: GO:0010200
name: response to chitin
namespace: biological_process
def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010201
name: response to continuous far red light stimulus by the high-irradiance response system
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0010218 ! response to far red light

[Term]
id: GO:0010202
name: response to low fluence red light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0009645 ! response to low light intensity stimulus
is_a: GO:0010114 ! response to red light

[Term]
id: GO:0010203
name: response to very low fluence red light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0010114 ! response to red light
is_a: GO:0055122 ! response to very low light intensity stimulus

[Term]
id: GO:0010205
name: photoinhibition
namespace: biological_process
def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126]
synonym: "photosystem II inhibition" BROAD []
xref: Wikipedia:Photoinhibition
is_a: GO:0009644 ! response to high light intensity
is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction
relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0010206
name: photosystem II repair
namespace: biological_process
def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition." [GOC:sm]
is_a: GO:0030091 ! protein repair
relationship: part_of GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0010207
name: photosystem II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms." [GOC:aa, GOC:pz]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0010208
name: pollen wall assembly
namespace: biological_process
def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117]
synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0045229 ! external encapsulating structure organization
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0010209
name: vacuolar sorting signal binding
namespace: molecular_function
def: "Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah]
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0010210
name: IAA-Phe conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine." [GOC:syr]
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010211
name: IAA-Leu conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine." [MetaCyc:RXN-2982]
xref: MetaCyc:RXN-2982
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010212
name: response to ionizing radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]
synonym: "response to ionising radiation" EXACT []
synonym: "response to ionizing radiation stimulus" EXACT []
is_a: GO:0009314 ! response to radiation

[Term]
id: GO:0010213
name: non-photoreactive DNA repair
namespace: biological_process
def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr]
synonym: "light-independent DNA repair" EXACT [GOC:syr]
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0010214
name: seed coat development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010215
name: cellulose microfibril organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730]
synonym: "cellulose microfibril organisation" EXACT []
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0071668 ! plant-type cell wall assembly

[Term]
id: GO:0010216
name: obsolete negative regulation of gene expression via chromosomal DNA cytosine methylation
namespace: biological_process
def: "OBSOLETE. An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal DNA." [PMID:11898023]
comment: This term was obsoleted because it represents the same process as negative regulation of gene expression via CpG island methylation ; GO:0044027.
synonym: "maintenance of DNA methylation" BROAD []
is_obsolete: true
replaced_by: GO:0044027

[Term]
id: GO:0010217
name: obsolete intracellular aluminum ion homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of aluminium ions within a cell." [GOC:lr, GOC:mah]
comment: This term was obsoleted because this process is not believed to exist.
synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah]
synonym: "cellular aluminum ion homeostasis" EXACT []
is_obsolete: true
replaced_by: GO:0140982

[Term]
id: GO:0010218
name: response to far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb]
synonym: "response to far red light stimulus" EXACT []
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0010219
name: regulation of vernalization response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010220
name: positive regulation of vernalization response
namespace: biological_process
def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
synonym: "activation of vernalization response" NARROW []
synonym: "stimulation of vernalization response" NARROW []
synonym: "up regulation of vernalization response" EXACT []
synonym: "up-regulation of vernalization response" EXACT []
synonym: "upregulation of vernalization response" EXACT []
is_a: GO:0010219 ! regulation of vernalization response
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010221
name: negative regulation of vernalization response
namespace: biological_process
def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
synonym: "down regulation of vernalization response" EXACT []
synonym: "down-regulation of vernalization response" EXACT []
synonym: "downregulation of vernalization response" EXACT []
synonym: "inhibition of vernalization response" NARROW []
is_a: GO:0010219 ! regulation of vernalization response
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010222
name: stem vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0010223
name: secondary shoot formation
namespace: biological_process
def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initiating the development of lateral organs." [GOC:tb, PMID:12815068]
synonym: "auxiliary shoot formation" RELATED []
synonym: "axillary shoot formation" RELATED []
synonym: "axillary shoot system formation" EXACT []
synonym: "shoot branching" RELATED []
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0010346 ! shoot axis formation

[Term]
id: GO:0010224
name: response to UV-B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb]
synonym: "response to medium wave ultraviolet light stimulus" EXACT []
synonym: "response to medium wave ultraviolet radiation stimulus" EXACT []
synonym: "response to UV-B light stimulus" EXACT []
synonym: "response to UV-B radiation stimulus" EXACT []
synonym: "response to UVB light stimulus" EXACT []
synonym: "response to UVB radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0010225
name: response to UV-C
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb]
synonym: "response to germicidal ultraviolet light stimulus" EXACT []
synonym: "response to germicidal ultraviolet radiation stimulus" EXACT []
synonym: "response to shortwave ultraviolet light stimulus" EXACT []
synonym: "response to shortwave ultraviolet radiation stimulus" EXACT []
synonym: "response to UV-C light stimulus" EXACT []
synonym: "response to UV-C radiation stimulus" EXACT []
synonym: "response to UVC light stimulus" EXACT []
synonym: "response to UVC radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0010226
name: response to lithium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010227
name: floral organ abscission
namespace: biological_process
def: "The controlled shedding of floral organs." [GOC:PO_curators, PMID:12972671, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009838 ! abscission
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0010228
name: vegetative to reproductive phase transition of meristem
namespace: biological_process
def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb]
synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135]
synonym: "flowering" RELATED []
synonym: "transition from vegetative to reproductive phase" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0009791 ! post-embryonic development
relationship: part_of GO:0048608 ! reproductive structure development

[Term]
id: GO:0010229
name: inflorescence development
namespace: biological_process
def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0090567 ! reproductive shoot system development

[Term]
id: GO:0010230
name: alternative respiration
namespace: biological_process
def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399]
is_a: GO:0009060 ! aerobic respiration

[Term]
id: GO:0010231
name: maintenance of seed dormancy
namespace: biological_process
def: "Any process that maintains a seed in a dormant state." [ISBN:9781405139830, PMID:9580097]
is_a: GO:0010162 ! seed dormancy process
is_a: GO:0097437 ! maintenance of dormancy

[Term]
id: GO:0010232
name: vascular transport
namespace: biological_process
def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0006810 ! transport

[Term]
id: GO:0010233
name: phloem transport
namespace: biological_process
def: "The directed movement of substances, into, out of or within the phloem during long distance transport between source and sink tissues." [GOC:sm, PMID:19025382]
is_a: GO:0010232 ! vascular transport

[Term]
id: GO:0010234
name: anther wall tapetum cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg]
synonym: "tapetal cell fate specification" BROAD [GOC:tb]
is_a: GO:0001708 ! cell fate specification
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0048657 ! anther wall tapetum cell differentiation

[Term]
id: GO:0010235
name: guard mother cell cytokinesis
namespace: biological_process
def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb]
synonym: "guard mother cell division" EXACT []
is_a: GO:0000911 ! cytokinesis by cell plate formation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010236
name: plastoquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm]
synonym: "plastoquinone anabolism" EXACT []
synonym: "plastoquinone biosynthesis" EXACT []
synonym: "plastoquinone formation" EXACT []
synonym: "plastoquinone synthesis" EXACT []
xref: MetaCyc:PWY-1581
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0010238
name: response to proline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010239
name: chloroplast mRNA processing
namespace: biological_process
def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738]
is_a: GO:0006397 ! mRNA processing
is_a: GO:0031425 ! chloroplast RNA processing

[Term]
id: GO:0010240
name: obsolete plastid pyruvate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A plastid complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637]
comment: This term is unnecessarily taxon-specific.
synonym: "dehydrogenase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045254

[Term]
id: GO:0010241
name: ent-kaurene oxidation to kaurenoic acid
namespace: biological_process
def: "The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase." [GOC:tb]
comment: Note that this term was in molecular function but was moved to biological process as it represents three successive reactions.
synonym: "ent-kaurene oxidation to ent-kaur-16-en-19-oate" EXACT []
synonym: "ent-kaurene oxidation to ent-kaurenoate" EXACT []
synonym: "ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase" EXACT []
is_a: GO:0033331 ! ent-kaurene metabolic process

[Term]
id: GO:0010242
name: oxygen evolving activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862]
synonym: "photosynthetic water oxidation" EXACT []
xref: EC:1.10.3.9
xref: MetaCyc:PSII-RXN
xref: RHEA:36359
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0010243
name: obsolete response to organonitrogen compound
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [PMID:9869419]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "response to organic nitrogen" EXACT []
is_obsolete: true

[Term]
id: GO:0010244
name: response to low fluence blue light stimulus by blue low-fluence system
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709]
synonym: "response to low fluence blue light" BROAD []
synonym: "response to low fluence blue light by blf system" EXACT []
is_a: GO:0009637 ! response to blue light
is_a: GO:0009645 ! response to low light intensity stimulus

[Term]
id: GO:0010245
name: radial microtubular system formation
namespace: biological_process
def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0010246
name: rhamnogalacturonan I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz]
synonym: "rhamnogalacturonan I anabolism" EXACT []
synonym: "rhamnogalacturonan I biosynthesis" EXACT []
synonym: "rhamnogalacturonan I formation" EXACT []
synonym: "rhamnogalacturonan I synthesis" EXACT []
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0010247
name: detection of phosphate ion
namespace: biological_process
def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "phosphate ion detection" EXACT []
synonym: "phosphate ion perception" RELATED []
synonym: "phosphate ion sensing" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0010248
name: establishment or maintenance of transmembrane electrochemical gradient
namespace: biological_process
def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:sm]
is_a: GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0010249
name: auxin conjugate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm]
synonym: "auxin conjugate metabolism" EXACT []
is_a: GO:0009850 ! auxin metabolic process

[Term]
id: GO:0010250
name: S-methylmethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340]
synonym: "S-methylmethionine anabolism" EXACT []
synonym: "S-methylmethionine biosynthesis" EXACT []
synonym: "S-methylmethionine formation" EXACT []
synonym: "S-methylmethionine synthesis" EXACT []
is_a: GO:0033477 ! S-methylmethionine metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0010252
name: obsolete auxin homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [PMID:22504182]
comment: This term was obsoleted in favor of 'intracellular' and 'multicellular organism-level' auxin homeostasis terms.
is_obsolete: true
consider: GO:0140964

[Term]
id: GO:0010253
name: UDP-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748]
synonym: "UDP-rhamnose anabolism" EXACT []
synonym: "UDP-rhamnose biosynthesis" EXACT []
synonym: "UDP-rhamnose formation" EXACT []
synonym: "UDP-rhamnose synthesis" EXACT []
xref: MetaCyc:PWY-3261
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033478 ! UDP-rhamnose metabolic process

[Term]
id: GO:0010254
name: nectary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010255
name: glucose mediated signaling pathway
namespace: biological_process
def: "The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm]
synonym: "glucose mediated signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling
relationship: part_of GO:0071333 ! cellular response to glucose stimulus

[Term]
id: GO:0010256
name: endomembrane system organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm]
subset: goslim_drosophila
synonym: "endomembrane organization" EXACT []
synonym: "endomembrane system organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0010257
name: NADH dehydrogenase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0010258
name: NADH dehydrogenase complex (plastoquinone) assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332]
is_a: GO:0010257 ! NADH dehydrogenase complex assembly
is_a: GO:0010275 ! NAD(P)H dehydrogenase complex assembly

[Term]
id: GO:0010259
name: obsolete multicellular organism aging
namespace: biological_process
def: "OBSOLETE. An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
comment: The reason for obsoletion is that this represents a phenotype.
is_obsolete: true

[Term]
id: GO:0010260
name: obsolete animal organ senescence
namespace: biological_process
alt_id: GO:0010261
def: "OBSOLETE. The process that occurs in an animal organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism." [GOC:tb]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0010262
name: somatic embryogenesis
namespace: biological_process
def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173]
is_a: GO:0009793 ! embryo development ending in seed dormancy
is_a: GO:0031099 ! regeneration

[Term]
id: GO:0010263
name: tricyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct]
synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process
is_a: GO:0016104 ! triterpenoid biosynthetic process

[Term]
id: GO:0010264
name: myo-inositol hexakisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [PMID:16107538]
synonym: "myo-inositol hexakisphosphate anabolism" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT []
synonym: "myo-inositol hexakisphosphate formation" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis" EXACT []
synonym: "phytate biosynthesis" EXACT []
synonym: "phytate biosynthetic process" EXACT []
is_a: GO:0032958 ! inositol phosphate biosynthetic process
is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process

[Term]
id: GO:0010265
name: SCF complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0010266
name: response to vitamin B1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz]
synonym: "response to thiamin" EXACT []
synonym: "response to thiamine" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0010267
name: ta-siRNA processing
namespace: biological_process
def: "A process leading to the generation of a functional trans-acting small interfering RNA (ta-siRNA). ta-siRNAs function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836, PMID:20687832]
synonym: "primary ta-siRNA processing" EXACT []
synonym: "production of small RNA involved in gene silencing by RNA" NARROW []
synonym: "production of ta-siRNAs involved in RNA interference" EXACT []
synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah]
is_a: GO:0030422 ! siRNA processing

[Term]
id: GO:0010268
name: brassinosteroid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell." [PMID:15908602]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0010269
name: response to selenium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0010270
name: photosystem II oxygen evolving complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ." [GOC:aa, PMID:16282331]
synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331]
is_a: GO:0010207 ! photosystem II assembly

[Term]
id: GO:0010271
name: regulation of chlorophyll catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392]
is_a: GO:0090056 ! regulation of chlorophyll metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
relationship: regulates GO:0015996 ! chlorophyll catabolic process

[Term]
id: GO:0010272
name: response to silver ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010273
name: detoxification of copper ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [GOC:kmv, PMID:16367966]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:1990169 ! stress response to copper ion

[Term]
id: GO:0010274
name: hydrotropism
namespace: biological_process
def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172]
xref: Wikipedia:Hydrotropism
is_a: GO:0009606 ! tropism

[Term]
id: GO:0010275
name: NAD(P)H dehydrogenase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm]
synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0010276
name: phytol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [RHEA:38055]
xref: EC:2.7.1.182
xref: MetaCyc:RXN-7683
xref: RHEA:38055
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0010277
name: chlorophyllide a oxygenase activity
namespace: molecular_function
alt_id: GO:0046407
def: "Catalysis of the reactions: chlorophyllide a + 2 H+ + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP+." [RHEA:30359]
synonym: "CAO activity" BROAD [EC:1.14.13.122]
synonym: "chlorophyll a oxygenation activity" EXACT []
synonym: "chlorophyll b synthesis activity" EXACT []
synonym: "chlorophyll-b synthesis activity" RELATED [EC:1.14.13.122]
synonym: "chlorophyllide a:oxygen 7-oxidoreduction activity" RELATED [EC:1.14.13.122]
synonym: "chlorophyllide-a oxygenation activity" RELATED [EC:1.14.13.122]
xref: EC:1.14.13.122
xref: RHEA:30359
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0010278
name: chloroplast outer membrane translocon
namespace: cellular_component
def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010279
name: indole-3-acetic acid amido synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate." [PMID:15659623]
synonym: "IAA amido synthetase activity" EXACT []
synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad]
synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad]
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0010280
name: UDP-L-rhamnose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O." [MetaCyc:RXN-5482, PMID:14701918]
synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb]
xref: MetaCyc:RXN-5482
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0010282
name: senescence-associated vacuole
namespace: cellular_component
def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448]
synonym: "senescence associated vacuole" EXACT []
is_a: GO:0000323 ! lytic vacuole
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0010283
name: pinoresinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+." [PMID:10066819, PMID:7592828]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010284
name: lariciresinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010285
name: L,L-diaminopimelate aminotransferase activity
namespace: molecular_function
alt_id: GO:0043742
def: "Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H+." [EC:2.6.1.83, RHEA:23988]
synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT []
synonym: "LL-DAP aminotransferase activity" RELATED [EC:2.6.1.83]
synonym: "LL-DAP-AT activity" RELATED [EC:2.6.1.83]
synonym: "LL-diaminopimelate aminotransferase activity" EXACT []
synonym: "LL-diaminopimelate transaminase activity" RELATED [EC:2.6.1.83]
xref: EC:2.6.1.83
xref: KEGG_REACTION:R07613
xref: MetaCyc:RXN-7737
xref: RHEA:23988
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0010286
name: heat acclimation
namespace: biological_process
def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators]
synonym: "thermotolerance" RELATED [GOC:tb]
is_a: GO:0009408 ! response to heat

[Term]
id: GO:0010287
name: plastoglobule
namespace: cellular_component
alt_id: GO:0010502
def: "A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379]
synonym: "PG" EXACT []
synonym: "plastoglobuli" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0010288
name: response to lead ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010289
name: homogalacturonan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543]
xref: MetaCyc:PWY-1061
is_a: GO:0010394 ! homogalacturonan metabolic process
is_a: GO:0052325 ! cell wall pectin biosynthetic process

[Term]
id: GO:0010290
name: chlorophyll catabolite transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other." [PMID:9681016]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0010291
name: carotene beta-ring hydroxylase activity
namespace: molecular_function
alt_id: GO:0042411
def: "Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene." [MetaCyc:MONOMER-12386, PMID:16492736]
synonym: "beta-carotene hydroxylase activity" NARROW []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0010292
name: GTP:GDP antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903]
is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0010293
name: abscisic aldehyde oxidase activity
namespace: molecular_function
alt_id: GO:0033725
def: "Catalysis of the reaction: a 2-cis-(+)-abscisic aldehyde + H2O + O2 = 2-cis-(+)-abscisate + H+ + H2O2." [RHEA:20529]
synonym: "AAO3" RELATED [EC:1.2.3.14]
synonym: "abscisic-aldehyde oxidase activity" RELATED [EC:1.2.3.14]
synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.14]
synonym: "AOdelta" RELATED [EC:1.2.3.14]
xref: EC:1.2.3.14
xref: KEGG_REACTION:R06957
xref: MetaCyc:1.2.3.14-RXN
xref: RHEA:20529
is_a: GO:0018488 ! aryl-aldehyde oxidase activity

[Term]
id: GO:0010294
name: abscisic acid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062]
xref: MetaCyc:RXN-8155
xref: RHEA:31031
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0010295
name: (+)-abscisic acid 8'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-abscisate + H+ + NADPH + O2 = (+)-8'-hydroxyabscisate + H2O + NADP+." [EC:1.14.14.137, RHEA:12897]
synonym: "(+)-ABA 8'-hydroxylase activity" RELATED [EC:1.14.14.137]
synonym: "ABA 8'-hydroxylase activity" RELATED [EC:1.14.14.137]
synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED []
synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" RELATED [EC:1.14.14.137]
synonym: "abscisic acid 8'-hydroxylase activity" EXACT []
xref: EC:1.14.14.137
xref: KEGG_REACTION:R07202
xref: MetaCyc:1.14.13.93-RXN
xref: RHEA:12897
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0010296
name: prenylcysteine methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [PMID:16870359, RHEA:48520]
xref: MetaCyc:RXN-8409
xref: RHEA:48520
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0010297
name: heteropolysaccharide binding
namespace: molecular_function
def: "Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue." [PMID:16640603]
synonym: "heteroglycan binding" EXACT []
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0010298
name: dihydrocamalexic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671]
xref: MetaCyc:RXN-8275
xref: RHEA:34807
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0010299
name: detoxification of cobalt ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cobalt ion (Co2+). These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0032025 ! response to cobalt ion

[Term]
id: GO:0010301
name: xanthoxin dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0033710
def: "Catalysis of the reaction: NAD+ + xanthoxin = (+)-abscisic aldehyde + H+ + NADH." [EC:1.1.1.288, RHEA:12548]
synonym: "ABA2" RELATED [EC:1.1.1.288]
synonym: "xanthoxin dehydrogenase activity" BROAD []
synonym: "xanthoxin oxidase activity" RELATED [EC:1.1.1.288]
synonym: "xanthoxin:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.288]
xref: EC:1.1.1.288
xref: KEGG_REACTION:R06954
xref: MetaCyc:1.1.1.288-RXN
xref: RHEA:12548
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0010303
name: limit dextrinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142]
synonym: "amylopectin-1,6-glucosidase activity" RELATED [EC:3.2.1.142]
synonym: "dextrin alpha-1,6-glucanohydrolase activity" RELATED [EC:3.2.1.142]
synonym: "R-enzyme" RELATED [EC:3.2.1.142]
xref: EC:3.2.1.142
xref: MetaCyc:3.2.1.142-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0010304
name: PSII associated light-harvesting complex II catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880]
synonym: "LHCII catabolism" RELATED []
is_a: GO:0030163 ! protein catabolic process

[Term]
id: GO:0010305
name: leaf vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0010306
name: rhamnogalacturonan II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267]
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process
is_a: GO:0052325 ! cell wall pectin biosynthetic process

[Term]
id: GO:0010307
name: acetylglutamate kinase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of acetylglutamate kinase." [PMID:16377628]
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0010308
name: acireductone dioxygenase (Ni2+-requiring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + CO + formate." [EC:1.13.11.53, RHEA:14161]
synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" RELATED [EC:1.13.11.53]
synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53]
synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53]
synonym: "ARD activity" RELATED [EC:1.13.11.53]
synonym: "E-2 activity" RELATED [EC:1.13.11.53]
xref: EC:1.13.11.53
xref: KEGG_REACTION:R07363
xref: MetaCyc:R146-RXN
xref: RHEA:14161
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010309
name: acireductone dioxygenase [iron(II)-requiring] activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+." [EC:1.13.11.54, RHEA:24504]
synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT []
synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" RELATED [EC:1.13.11.54]
synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD []
synonym: "aci-reductone dioxygenase" BROAD []
synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT []
synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54]
synonym: "ARD'" RELATED []
synonym: "ARD1" RELATED []
synonym: "E-2'" RELATED []
xref: EC:1.13.11.54
xref: KEGG_REACTION:R07364
xref: MetaCyc:R147-RXN
xref: Reactome:R-HSA-1237119 "Acireductone is oxidized to MOB"
xref: RHEA:24504
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010310
name: regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119]
synonym: "regulation of hydrogen peroxide metabolism" EXACT []
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010311
name: lateral root formation
namespace: biological_process
alt_id: GO:0010386
def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators, PMID:17259263]
synonym: "lateral root primordium development" EXACT []
is_a: GO:0009791 ! post-embryonic development
is_a: GO:1905393 ! plant organ formation
relationship: part_of GO:0010102 ! lateral root morphogenesis

[Term]
id: GO:0010312
name: detoxification of zinc ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:1990359 ! stress response to zinc ion

[Term]
id: GO:0010313
name: phytochrome binding
namespace: molecular_function
def: "Binding to a phytochrome." [PMID:15486102]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0010314
name: phosphatidylinositol-5-phosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators]
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0010315
name: auxin export across the plasma membrane
namespace: biological_process
def: "The directed movement of auxins from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:tair_curators, PMID:16990790]
synonym: "auxin efflux" BROAD []
synonym: "auxin export" BROAD []
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
is_a: GO:0060918 ! auxin transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0010316
name: pyrophosphate-dependent phosphofructokinase complex
namespace: cellular_component
def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409]
subset: goslim_pir
synonym: "PFK complex" RELATED []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0010317
name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex
namespace: cellular_component
def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409]
synonym: "PFK complex, alpha-subunit" RELATED []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex

[Term]
id: GO:0010318
name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex
namespace: cellular_component
def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409]
synonym: "PFK complex, beta-subunit" RELATED []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex

[Term]
id: GO:0010319
name: stromule
namespace: cellular_component
def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010]
synonym: "Stroma-filled tubule" RELATED []
xref: Wikipedia:Stromule
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0010320
name: obsolete arginine/lysine endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators]
comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases.
synonym: "arginine/lysine endopeptidase activity" EXACT []
is_obsolete: true
consider: GO:0004175
consider: GO:0004197

[Term]
id: GO:0010321
name: regulation of vegetative phase change
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0010050 ! vegetative phase change

[Term]
id: GO:0010322
name: regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478]
synonym: "regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

[Term]
id: GO:0010323
name: negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478]
synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW []
synonym: "negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

[Term]
id: GO:0010324
name: membrane invagination
namespace: biological_process
alt_id: GO:1902534
def: "The infolding of a membrane." [GOC:tb]
subset: goslim_yeast
synonym: "single-organism membrane invagination" RELATED []
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0010325
name: raffinose family oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators]
synonym: "raffinose family oligosaccharide biosynthesis" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process

[Term]
id: GO:0010326
name: methionine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid." [PMID:17056707, RHEA:31763]
xref: EC:2.6.1.88
xref: MetaCyc:R15-RXN
xref: RHEA:31763
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0010327
name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883]
synonym: "hexenol acetyltransferase" RELATED []
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0010328
name: auxin influx transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804]
synonym: "auxin influx facilitator" RELATED []
is_a: GO:0080161 ! auxin transmembrane transporter activity

[Term]
id: GO:0010329
name: auxin efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804]
synonym: "auxin efflux carrier" RELATED []
synonym: "auxin efflux facilitator" RELATED []
is_a: GO:0080161 ! auxin transmembrane transporter activity

[Term]
id: GO:0010330
name: cellulose synthase complex
namespace: cellular_component
def: "A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238, PMID:18485800, PMID:21307367]
synonym: "CESA complex" EXACT []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0010331
name: gibberellin binding
namespace: molecular_function
def: "Binding to a gibberellin, a plant hormone that regulates aspects of plant growth." [GOC:tair_curators]
synonym: "gibberellic acid receptor" RELATED []
synonym: "gibberellin receptor" RELATED []
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0010332
name: response to gamma radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators]
synonym: "response to gamma ray" RELATED []
synonym: "response to gamma-ray photon" RELATED []
is_a: GO:0010212 ! response to ionizing radiation

[Term]
id: GO:0010333
name: terpene synthase activity
namespace: molecular_function
def: "Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units." [GOC:tair_curators]
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0010334
name: sesquiterpene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons." [GOC:tair_curators]
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0010335
name: response to non-ionic osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators]
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0010336
name: gibberellic acid homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763]
synonym: "gibberellin homeostasis" BROAD []
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0010337
name: regulation of salicylic acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119]
synonym: "regulation of salicylic acid metabolism" RELATED []
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0009696 ! salicylic acid metabolic process

[Term]
id: GO:0010338
name: leaf formation
namespace: biological_process
def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators]
is_a: GO:0099402 ! plant organ development
is_a: GO:1905393 ! plant organ formation
relationship: part_of GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0010339
name: external side of cell wall
namespace: cellular_component
def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005618 ! cell wall
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0010340
name: carboxyl-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0010341
name: gibberellin carboxyl-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester." [PMID:17220201]
is_a: GO:0010340 ! carboxyl-O-methyltransferase activity

[Term]
id: GO:0010342
name: endosperm cellularization
namespace: biological_process
def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698]
synonym: "cellularization of endosperm" EXACT []
is_a: GO:0007349 ! cellularization

[Term]
id: GO:0010343
name: singlet oxygen-mediated programmed cell death
namespace: biological_process
def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:17075038]
synonym: "light-dependent programmed cell death" BROAD []
synonym: "programmed cell death in response to singlet oxygen" EXACT []
is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species
relationship: part_of GO:0071452 ! cellular response to singlet oxygen

[Term]
id: GO:0010344
name: seed oilbody biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495]
synonym: "oleosome biogenesis" RELATED []
synonym: "seed oil body organization" EXACT []
synonym: "spherosome biogenesis" RELATED []
is_a: GO:0044085 ! cellular component biogenesis
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010345
name: suberin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262]
xref: MetaCyc:PWY-1121
is_a: GO:0009699 ! phenylpropanoid biosynthetic process

[Term]
id: GO:0010346
name: shoot axis formation
namespace: biological_process
def: "The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb]
synonym: "shoot formation" RELATED []
is_a: GO:1905393 ! plant organ formation
relationship: part_of GO:0010016 ! shoot system morphogenesis

[Term]
id: GO:0010347
name: L-galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667]
xref: MetaCyc:RXNQT-4142
xref: RHEA:26349
is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity

[Term]
id: GO:0010348
name: lithium:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011]
synonym: "lithium:hydrogen antiporter activity" EXACT []
is_a: GO:0051139 ! metal cation:proton antiporter activity

[Term]
id: GO:0010349
name: L-galactose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629, RHEA:31559]
synonym: "L-galactose 1-dehydrogenase activity" RELATED []
xref: EC:1.1.1.316
xref: MetaCyc:RXN-1884
xref: RHEA:31559
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010350
name: cellular response to magnesium starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010351
name: lithium ion transport
namespace: biological_process
def: "The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:17270011]
synonym: "lithium transport" EXACT []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0010352
name: lithium ion export across the plasma membrane
namespace: biological_process
def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011]
synonym: "lithium export" EXACT []
synonym: "lithium ion efflux" RELATED []
synonym: "lithium ion export" RELATED []
is_a: GO:0090452 ! lithium ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0010353
name: response to trehalose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
synonym: "response to trehalose stimulus" EXACT [GOC:dos]
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0010354
name: homogentisate prenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0010355
name: homogentisate farnesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol." [PMID:16989822]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010356
name: homogentisate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + H+ + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate." [EC:2.5.1.116, GOC:pz, PMID:16989822]
synonym: "HGGT activity" EXACT [EC:2.5.1.116]
synonym: "homogentisate geranylgeranyl transferase activity" EXACT [PMID:21223386]
xref: EC:2.5.1.116
xref: MetaCyc:RXN-14929
xref: RHEA:38003
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010357
name: homogentisate solanesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-nonaprenyl diphosphate + H+ + homogentisate = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate." [PMID:16989822, RHEA:37995]
synonym: "homogentisate solanyltransferase activity" EXACT []
synonym: "HST activity" EXACT [EC:2.5.1.117]
xref: EC:2.5.1.117
xref: MetaCyc:RXN-2761
xref: RHEA:37995
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010358
name: leaf shaping
namespace: biological_process
def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475]
synonym: "leaf structural organization" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0010359
name: regulation of anion channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842]
subset: gocheck_obsoletion_candidate
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:1903959 ! regulation of monoatomic anion transmembrane transport

[Term]
id: GO:0010360
name: negative regulation of anion channel activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842]
subset: gocheck_obsoletion_candidate
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1903960 ! negative regulation of anion transmembrane transport

[Term]
id: GO:0010361
name: regulation of anion channel activity by blue light
namespace: biological_process
def: "Any process in which blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842]
subset: gocheck_obsoletion_candidate
synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010359 ! regulation of anion channel activity

[Term]
id: GO:0010362
name: obsolete negative regulation of anion channel activity by blue light
namespace: biological_process
def: "OBSOLETE. Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842]
comment: This term was obsoleted because it represents a molecular function.
synonym: "inhibition by blue light of anion channel activity" NARROW []
synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0010363
name: regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244]
comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'.
synonym: "regulation of HR" EXACT []
synonym: "regulation of HR-PCD" EXACT []
synonym: "regulation of plant hypersensitive response" EXACT []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0010364
name: regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
relationship: regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010365
name: positive regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010366
name: negative regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010367
name: extracellular isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators]
is_a: GO:0043033 ! isoamylase complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0010368
name: chloroplast isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators]
is_a: GO:0043033 ! isoamylase complex
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0010369
name: chromocenter
namespace: cellular_component
def: "A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888]
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0010370
name: perinucleolar chromocenter
namespace: cellular_component
def: "A chromocenter adjacent to the nucleolus." [PMID:15805479]
is_a: GO:0010369 ! chromocenter

[Term]
id: GO:0010371
name: regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010372
name: positive regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "positive regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010373
name: negative regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010374
name: stomatal complex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0090558 ! plant epidermis development

[Term]
id: GO:0010375
name: stomatal complex patterning
namespace: biological_process
def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0010376
name: stomatal complex formation
namespace: biological_process
def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010103 ! stomatal complex morphogenesis

[Term]
id: GO:0010377
name: guard cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259]
synonym: "stomatal cell fate commitment" RELATED []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0010052 ! guard cell differentiation

[Term]
id: GO:0010378
name: temperature compensation of the circadian clock
namespace: biological_process
def: "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099]
synonym: "regulation of the circadian clock by temperature" RELATED []
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0042752 ! regulation of circadian rhythm

[Term]
id: GO:0010379
name: phaseic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271]
xref: MetaCyc:PWY-5271
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0043289 ! apocarotenoid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0010380
name: regulation of chlorophyll biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312]
is_a: GO:0090056 ! regulation of chlorophyll metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
relationship: regulates GO:0015995 ! chlorophyll biosynthetic process

[Term]
id: GO:0010381
name: peroxisome-chloroplast membrane tethering
namespace: biological_process
def: "The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:17215364]
synonym: "attachment of peroxisome to chloroplast" EXACT []
is_a: GO:0140056 ! organelle localization by membrane tethering

[Term]
id: GO:0010383
name: cell wall polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators]
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0010384
name: cell wall proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators]
synonym: "cell wall proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0010385
name: double-stranded methylated DNA binding
namespace: molecular_function
def: "Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, PMID:17242155]
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0010387
name: COP9 signalosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927]
synonym: "signalosome assembly" BROAD [GOC:krc]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0010389
name: regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565]
synonym: "regulation of mitotic entry" EXACT [GOC:vw]
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition
relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0010390
name: obsolete histone monoubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histones by addition of a single ubiquitin group." [PMID:17329563]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0010391
name: glucomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators]
synonym: "glucomannan metabolism" EXACT []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0010392
name: galactoglucomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators]
synonym: "galactoglucomannan metabolism" RELATED []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0010393
name: galacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators]
synonym: "galacturonan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0010394
name: homogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators]
synonym: "homogalacturonan metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010395
name: rhamnogalacturonan I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators]
synonym: "RGI metabolism" RELATED []
synonym: "rhamnogalacturonan I metabolism" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0052546 ! cell wall pectin metabolic process

[Term]
id: GO:0010396
name: rhamnogalacturonan II metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators]
synonym: "rhamnogalacturonan II metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010397
name: apiogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators]
synonym: "apiogalacturonan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0010398
name: xylogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators]
synonym: "xylogalacturonan metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010399
name: rhamnogalacturonan I backbone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators]
synonym: "rhamnogalacturonan I backbone metabolism" EXACT []
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process

[Term]
id: GO:0010400
name: rhamnogalacturonan I side chain metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators]
synonym: "rhamnogalacturonan I side chain metabolism" EXACT []
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process

[Term]
id: GO:0010401
name: pectic galactan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic galactan metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010402
name: pectic arabinan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic arabinan metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010403
name: pectic arabinogalactan I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic arabinogalactan I metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010404
name: cell wall hydroxyproline-rich glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators]
synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT []
is_a: GO:0010384 ! cell wall proteoglycan metabolic process

[Term]
id: GO:0010405
name: arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators]
synonym: "arabinogalactan protein metabolism" EXACT []
is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process

[Term]
id: GO:0010406
name: classical arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators]
synonym: "classical-arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010407
name: non-classical arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators]
synonym: "non-classical arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010408
name: fasciclin-like arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators]
synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010409
name: extensin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators]
synonym: "extensin metabolism" EXACT []
is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process

[Term]
id: GO:0010410
name: hemicellulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators]
synonym: "hemicellulose metabolism" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process

[Term]
id: GO:0010411
name: xyloglucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators]
synonym: "xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0010410 ! hemicellulose metabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0010412
name: mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators]
synonym: "mannan metabolism" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process

[Term]
id: GO:0010413
name: glucuronoxylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators]
synonym: "glucuronoxylan metabolism" EXACT []
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0010414
name: glucuronoarabinoxylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators]
synonym: "glucuronoarabinoxylan metabolism" EXACT []
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process

[Term]
id: GO:0010415
name: unsubstituted mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators]
synonym: "unsubstituted mannan metabolism" EXACT []
is_a: GO:0010412 ! mannan metabolic process

[Term]
id: GO:0010416
name: arabinoxylan-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an arabinoxylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators]
synonym: "arabinoxylan metabolic process" RELATED []
synonym: "arabinoxylan metabolism" RELATED []
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0010417
name: glucuronoxylan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators]
synonym: "glucuronoxylan anabolism" EXACT []
synonym: "glucuronoxylan biosynthesis" EXACT []
synonym: "glucuronoxylan formation" EXACT []
synonym: "glucuronoxylan synthesis" EXACT []
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0045492 ! xylan biosynthetic process

[Term]
id: GO:0010418
name: rhamnogalacturonan II backbone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators]
synonym: "rhamnogalacturonan II backbone metabolism" EXACT []
is_a: GO:0010394 ! homogalacturonan metabolic process
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process

[Term]
id: GO:0010419
name: rhamnogalacturonan II side chain metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators]
synonym: "rhamnogalacturonan II side chain metabolism" EXACT []
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process

[Term]
id: GO:0010420
name: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
namespace: molecular_function
alt_id: GO:1990886
def: "Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+." [PMID:10419476, PMID:23190198, PMID:9628017, RHEA:44452]
comment: Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
synonym: "polyprenyldihydroxybenzoate methyltransferase activity" RELATED []
xref: EC:2.1.1.114
xref: MetaCyc:RXN-9281
xref: Reactome:R-HSA-2162193 "COQ3 methylates DHDB"
xref: RHEA:44452
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0010421
name: hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:16036580]
synonym: "programmed cell death in response to hydrogen peroxide" EXACT []
is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species

[Term]
id: GO:0010422
name: regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903]
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process

[Term]
id: GO:0010423
name: negative regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903]
is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process

[Term]
id: GO:0010424
name: obsolete DNA methylation on cytosine within a CG sequence
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0031507
consider: GO:0051718

[Term]
id: GO:0010425
name: obsolete DNA methylation on cytosine within a CNG sequence
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0010426
name: obsolete DNA methylation on cytosine within a CHH sequence
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah]
synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb]
synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0009008

[Term]
id: GO:0010427
name: abscisic acid binding
namespace: molecular_function
def: "Binding to abscisic acid, a plant hormone that regulates aspects of plant growth." [PMID:17347412]
synonym: "ABA binding" RELATED []
synonym: "abscisate binding" RELATED []
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0042562 ! hormone binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0010428
name: methyl-CpNpG binding
namespace: molecular_function
def: "Binding to a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0010429
name: methyl-CpNpN binding
namespace: molecular_function
def: "Binding to a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0010430
name: fatty acid omega-oxidation
namespace: biological_process
def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574]
xref: MetaCyc:PWY-2724
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0010431
name: seed maturation
namespace: biological_process
def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0021700 ! developmental maturation
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010432
name: bract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:0048827 ! phyllome development

[Term]
id: GO:0010433
name: bract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:1905392 ! plant organ morphogenesis
relationship: part_of GO:0010432 ! bract development

[Term]
id: GO:0010434
name: bract formation
namespace: biological_process
def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:1905393 ! plant organ formation
relationship: part_of GO:0010433 ! bract morphogenesis

[Term]
id: GO:0010435
name: obsolete 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0." [PMID:16963437]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity" EXACT [MetaCyc:RXN-10695]
synonym: "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity" EXACT []
synonym: "OPC-8:0 CoA ligase activity" EXACT []
is_obsolete: true
consider: GO:0031956

[Term]
id: GO:0010436
name: carotenoid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333]
synonym: "carotenoid-cleaving dioxygenase" RELATED []
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010437
name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333]
is_a: GO:0010436 ! carotenoid dioxygenase activity

[Term]
id: GO:0010438
name: cellular response to sulfur starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010439
name: regulation of glucosinolate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480]
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0010440
name: stomatal lineage progression
namespace: biological_process
def: "The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0010374 ! stomatal complex development

[Term]
id: GO:0010441
name: guard cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0010052 ! guard cell differentiation

[Term]
id: GO:0010442
name: guard cell morphogenesis
namespace: biological_process
def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb]
synonym: "guard cell morphogenesis during differentiation" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0010441 ! guard cell development

[Term]
id: GO:0010443
name: meristemoid mother cell division
namespace: biological_process
def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb]
synonym: "meristemoid division" RELATED []
is_a: GO:0000911 ! cytokinesis by cell plate formation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010444
name: guard mother cell differentiation
namespace: biological_process
def: "The process in which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb]
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010445
name: nuclear dicing body
namespace: cellular_component
def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570]
synonym: "D body" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0010446
name: response to alkaline pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, Wikipedia:PH]
synonym: "response to alkalinity" BROAD []
synonym: "response to basic pH" EXACT []
is_a: GO:0009268 ! response to pH

[Term]
id: GO:0010447
name: response to acidic pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, Wikipedia:PH]
comment: This term should be used to annotate instances where a cell or organism is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0001101 'response to acid chemical'.
synonym: "response to acidity" BROAD []
is_a: GO:0009268 ! response to pH

[Term]
id: GO:0010448
name: vegetative meristem growth
namespace: biological_process
def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928]
is_a: GO:0035266 ! meristem growth
is_a: GO:0080186 ! developmental vegetative growth
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0010449
name: root meristem growth
namespace: biological_process
def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb]
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010450
name: inflorescence meristem growth
namespace: biological_process
def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0010229 ! inflorescence development

[Term]
id: GO:0010451
name: floral meristem growth
namespace: biological_process
def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010452
name: obsolete histone H3-K36 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone." [GOC:pr, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K36 methylation" EXACT [GOC:tb]
synonym: "histone H3K36me" EXACT [GOC:tb]
synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb]
is_obsolete: true

[Term]
id: GO:0010453
name: regulation of cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010454
name: negative regulation of cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010455
name: positive regulation of cell fate commitment
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010456
name: cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb]
is_a: GO:0061351 ! neural precursor cell proliferation

[Term]
id: GO:0010457
name: centriole-centriole cohesion
namespace: biological_process
def: "The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007098 ! centrosome cycle

[Term]
id: GO:0010458
name: exit from mitosis
namespace: biological_process
def: "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "exit from mitotic division" EXACT []
synonym: "mitotic exit" EXACT []
is_a: GO:0044772 ! mitotic cell cycle phase transition
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0010459
name: negative regulation of heart rate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0045822 ! negative regulation of heart contraction

[Term]
id: GO:0010460
name: positive regulation of heart rate
namespace: biological_process
def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0045823 ! positive regulation of heart contraction

[Term]
id: GO:0010461
name: light-activated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a monoatomic ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb]
is_a: GO:0005216 ! monoatomic ion channel activity

[Term]
id: GO:0010462
name: obsolete regulation of light-activated voltage-gated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0010463
name: mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0010464
name: regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0010465
name: nerve growth factor receptor activity
namespace: molecular_function
def: "Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb]
synonym: "beta-nerve growth factor receptor activity" EXACT [PR:000011194]
synonym: "NGF receptor activity" EXACT [PR:000011194]
is_a: GO:0005030 ! neurotrophin receptor activity

[Term]
id: GO:0010466
name: negative regulation of peptidase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:0010467
name: gene expression
namespace: biological_process
def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
subset: goslim_flybase_ribbon
xref: Wikipedia:Gene_expression
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010468
name: regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_plant_ribbon
synonym: "gene regulation" RELATED [GOC:cjm]
synonym: "regulation of gene product expression" RELATED []
synonym: "regulation of protein expression" NARROW []
xref: Wikipedia:Regulation_of_gene_expression
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0010467 ! gene expression

[Term]
id: GO:0010469
name: regulation of signaling receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of receptor activity" BROAD []
synonym: "regulation of signalling receptor activity" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0010470
name: regulation of gastrulation
namespace: biological_process
def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0007369 ! gastrulation

[Term]
id: GO:0010471
name: GDP-galactose:mannose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + beta-L-galactose-1-phosphate." [PMID:17485667, RHEA:65708]
synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER]
synonym: "GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-12]
xref: MetaCyc:RXN4FS-12
xref: RHEA:65708
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010472
name: GDP-galactose:glucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-glucose 1-phosphate = beta-L-galactose-1-phosphate + GDP-alpha-D-glucose." [PMID:17485667, RHEA:65712]
synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER]
synonym: "GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-13]
xref: MetaCyc:RXN4FS-13
xref: RHEA:65712
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010473
name: GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol." [PMID:17485667]
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010476
name: gibberellin mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411]
synonym: "gibberellin-mediated signalling" EXACT [GOC:mah]
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071370 ! cellular response to gibberellin stimulus

[Term]
id: GO:0010477
name: response to sulfur dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010478
name: chlororespiration
namespace: biological_process
def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537]
is_a: GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0010479
name: stele development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010480
name: microsporocyte differentiation
namespace: biological_process
def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248, PMID:16751349]
synonym: "pollen mother cell differentiation" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048533 ! sporocyte differentiation
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0010481
name: epidermal cell division
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124]
synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0010482
name: regulation of epidermal cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124]
synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0010481 ! epidermal cell division

[Term]
id: GO:0010483
name: pollen tube reception
namespace: biological_process
def: "An interaction between the pollen tube, part of the male gametophyte, and the female gametophyte (typically the synergid cells), that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [PMID:37640641]
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0010484
name: histone H3 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [PMID:19056256]
synonym: "H3 histone acetylase activity" EXACT []
synonym: "H3 histone acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0010485
name: histone H4 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [PMID:19056256]
synonym: "H4 histone acetylase activity" EXACT []
synonym: "H4 histone acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0010486
name: manganese:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518]
synonym: "manganese:hydrogen antiporter activity" EXACT []
is_a: GO:0005384 ! manganese ion transmembrane transporter activity
is_a: GO:0051139 ! metal cation:proton antiporter activity

[Term]
id: GO:0010487
name: thermospermine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+." [EC:2.5.1.79, MetaCyc:RXN-11190, PMID:17560575]
xref: EC:2.5.1.79
xref: MetaCyc:RXN-11190
xref: RHEA:30515
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0010488
name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273]
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0010489
name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829]
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0010490
name: UDP-4-keto-rhamnose-4-keto-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010491
name: UTP:arabinose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835]
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0010492
name: maintenance of shoot apical meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010493
name: Lewis a epitope biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273]
synonym: "LE A biosynthetic process" RELATED []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0010494
name: cytoplasmic stress granule
namespace: cellular_component
def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]
synonym: "cytoplasmic mRNP granule" EXACT []
synonym: "stress granule" EXACT []
xref: Wikipedia:Stress_granule
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0010495
name: siRNA-mediated long-distance post-transcriptional gene silencing
namespace: biological_process
def: "An siRNA-mediated posttranscriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs, and in which the silencing signal originates in one tissue and occurs in a different tissue." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412]
synonym: "long-distance posttranscriptional gene silencing" BROAD []
synonym: "long-distance propagation of posttranscriptional gene silencing" BROAD [GOC:dph, GOC:tb]
synonym: "siRNA-mediated long-distance posttranscriptional gene silencing" EXACT []
is_a: GO:0090625 ! siRNA-mediated gene silencing by mRNA destabilization

[Term]
id: GO:0010496
name: intercellular transport
namespace: biological_process
alt_id: GO:1902585
def: "The movement of substances between cells." [GOC:dhl]
synonym: "single organism intercellular transport" RELATED [GOC:TermGenie]
synonym: "single-organism intercellular transport" RELATED []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0010497
name: plasmodesmata-mediated intercellular transport
namespace: biological_process
alt_id: GO:1902587
def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829]
synonym: "plasmodesma-mediated cell-to-cell transport" EXACT []
synonym: "plasmodesma-mediated intercellular transport" EXACT []
synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT []
synonym: "single organism plasmodesmata-mediated intercellular transport" RELATED [GOC:TermGenie]
synonym: "single-organism plasmodesmata-mediated intercellular transport" RELATED []
is_a: GO:0010496 ! intercellular transport

[Term]
id: GO:0010498
name: proteasomal protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]
synonym: "proteasome-mediated protein catabolic process" EXACT []
synonym: "proteasome-mediated protein catabolism" EXACT []
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:0010499
name: proteasomal ubiquitin-independent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb]
is_a: GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0010500
name: transmitting tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426]
is_a: GO:0048467 ! gynoecium development

[Term]
id: GO:0010501
name: RNA secondary structure unwinding
namespace: biological_process
def: "The process in which a secondary structure of RNA are broken or 'melted'." [PMID:17169986]
synonym: "RNA duplex unwinding" EXACT [GOC:ecd]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0010503
name: obsolete negative regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
is_obsolete: true

[Term]
id: GO:0010504
name: obsolete regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
is_obsolete: true

[Term]
id: GO:0010505
name: obsolete positive regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
is_obsolete: true

[Term]
id: GO:0010506
name: regulation of autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
relationship: regulates GO:0006914 ! autophagy

[Term]
id: GO:0010507
name: negative regulation of autophagy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010506 ! regulation of autophagy
relationship: negatively_regulates GO:0006914 ! autophagy

[Term]
id: GO:0010508
name: positive regulation of autophagy
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010506 ! regulation of autophagy
relationship: positively_regulates GO:0006914 ! autophagy

[Term]
id: GO:0010509
name: intracellular polyamine homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of polyamine within a cell." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731]
synonym: "polyamine homeostasis" RELATED []
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0010510
name: regulation of acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb]
is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process
relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate

[Term]
id: GO:0010511
name: regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010512
name: negative regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010513
name: positive regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010514
name: induction of conjugation with cellular fusion
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb]
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion

[Term]
id: GO:0010515
name: negative regulation of induction of conjugation with cellular fusion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion
relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion

[Term]
id: GO:0010516
name: negative regulation of cellular response to nitrogen starvation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation

[Term]
id: GO:0010517
name: regulation of phospholipase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0010518
name: positive regulation of phospholipase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010517 ! regulation of phospholipase activity
is_a: GO:0060193 ! positive regulation of lipase activity

[Term]
id: GO:0010519
name: negative regulation of phospholipase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010517 ! regulation of phospholipase activity
is_a: GO:0060192 ! negative regulation of lipase activity

[Term]
id: GO:0010520
name: regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010521
name: telomerase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of telomerase." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0010522
name: regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
relationship: regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010523
name: negative regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
is_a: GO:0051481 ! negative regulation of cytosolic calcium ion concentration
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010524
name: positive regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010525
name: obsolete regulation of transposition, RNA-mediated
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
comment: This term was obsoleted because only negative regulation is known to exist (retrotransposon silencing).
is_obsolete: true
consider: GO:0032197

[Term]
id: GO:0010526
name: transposable element silencing
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transposable element expression. Includes both DNA transposons and retrotransposons." [GOC:dph, GOC:tb, PMID:32823517]
synonym: "negative regulation of transposition, RNA-mediated" EXACT []
synonym: "retrotransposon silencing" NARROW []
xref: Wikipedia:Retrotransposon_silencing
is_a: GO:0045814 ! negative regulation of gene expression, epigenetic
relationship: negatively_regulates GO:0032197 ! retrotransposition

[Term]
id: GO:0010527
name: obsolete positive regulation of transposition, RNA-mediated
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true
consider: GO:0032197

[Term]
id: GO:0010528
name: obsolete regulation of transposition
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0010529
name: obsolete negative regulation of transposition
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true
consider: GO:0010526

[Term]
id: GO:0010530
name: obsolete positive regulation of transposition
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
comment: This term was obsoleted because this process is not known to exist.
is_obsolete: true

[Term]
id: GO:0010533
name: obsolete regulation of activation of Janus kinase activity
namespace: biological_process
alt_id: GO:0010532
alt_id: GO:0010534
def: "OBSOLETE. Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of activation of JAK1 kinase activity" NARROW []
synonym: "regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of activation of JAK2 kinase activity" NARROW []
synonym: "regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0007259

[Term]
id: GO:0010536
name: obsolete positive regulation of activation of Janus kinase activity
namespace: biological_process
alt_id: GO:0010535
alt_id: GO:0010537
def: "OBSOLETE. Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of activation of JAK1 kinase activity" NARROW []
synonym: "positive regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of activation of JAK2 kinase activity" NARROW []
synonym: "positive regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0007259

[Term]
id: GO:0010538
name: obsolete Hsp27 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'.
synonym: "Hsp27 protein regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0051008
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010539
name: obsolete Hsp27 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'.
synonym: "Hsp27 protein inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0051008
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010540
name: basipetal auxin transport
namespace: biological_process
def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441]
is_a: GO:0009926 ! auxin polar transport

[Term]
id: GO:0010541
name: acropetal auxin transport
namespace: biological_process
def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441]
is_a: GO:0009926 ! auxin polar transport

[Term]
id: GO:0010542
name: nitrate efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane." [GOC:mah]
is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0010543
name: regulation of platelet activation
namespace: biological_process
def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010544
name: negative regulation of platelet activation
namespace: biological_process
def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:0050866 ! negative regulation of cell activation
relationship: negatively_regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010545
name: obsolete Hsp90 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'.
synonym: "Hsp90 protein regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0051879
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010546
name: obsolete Hsp90 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'.
synonym: "Hsp90 protein inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0051879
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010547
name: thylakoid membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733]
synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010027 ! thylakoid membrane organization
is_a: GO:0030397 ! membrane disassembly

[Term]
id: GO:0010548
name: regulation of thylakoid membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733]
synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010549 ! regulation of membrane disassembly
relationship: regulates GO:0010547 ! thylakoid membrane disassembly

[Term]
id: GO:0010549
name: regulation of membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0030397 ! membrane disassembly

[Term]
id: GO:0010550
name: regulation of PSII associated light-harvesting complex II catabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb]
synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733]
synonym: "regulation of LHCII degradation" EXACT [PMID:17416733]
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process

[Term]
id: GO:0010555
name: response to mannitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." [PMID:17999646]
synonym: "response to mannitol stimulus" EXACT [GOC:dos]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0010556
name: regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010557
name: positive regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010558
name: negative regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010559
name: regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
relationship: regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010560
name: positive regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process
relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010561
name: negative regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process
relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010562
name: positive regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: positively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010563
name: negative regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010564
name: regulation of cell cycle process
namespace: biological_process
def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
relationship: regulates GO:0022402 ! cell cycle process

[Term]
id: GO:0010565
name: regulation of ketone metabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0042180 ! ketone metabolic process

[Term]
id: GO:0010566
name: regulation of ketone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0010567
name: regulation of ketone catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0042182 ! ketone catabolic process

[Term]
id: GO:0010568
name: regulation of budding cell apical bud growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630]
is_a: GO:0040008 ! regulation of growth
relationship: regulates GO:0007118 ! budding cell apical bud growth

[Term]
id: GO:0010569
name: regulation of double-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:2000779 ! regulation of double-strand break repair
relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0010570
name: regulation of filamentous growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0040008 ! regulation of growth
relationship: regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0010571
name: positive regulation of nuclear cell cycle DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]
synonym: "positive regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of DNA replication involved in S phase" EXACT []
synonym: "positive regulation of DNA replication involved in S-phase" EXACT []
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:2000105 ! positive regulation of DNA-templated DNA replication
relationship: positively_regulates GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0010572
name: positive regulation of platelet activation
namespace: biological_process
def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0050867 ! positive regulation of cell activation
relationship: positively_regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010573
name: vascular endothelial growth factor production
namespace: biological_process
def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl]
synonym: "VEGF production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0010574
name: regulation of vascular endothelial growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0010573 ! vascular endothelial growth factor production

[Term]
id: GO:0010575
name: positive regulation of vascular endothelial growth factor production
namespace: biological_process
def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:BHF, GOC:rl]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0010574 ! regulation of vascular endothelial growth factor production
relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production

[Term]
id: GO:0010578
name: obsolete regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT []
synonym: "regulation of adenylate cyclase activity involved in G-protein signaling pathway" EXACT [GOC:signaling]
synonym: "regulation of adenylate cyclase activity involved in G-protein signalling" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0010581
name: regulation of starch biosynthetic process
namespace: biological_process
def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb]
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:2000904 ! regulation of starch metabolic process
relationship: regulates GO:0019252 ! starch biosynthetic process

[Term]
id: GO:0010582
name: floral meristem determinacy
namespace: biological_process
def: "The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010022 ! meristem determinacy
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010583
name: response to cyclopentenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0010584
name: pollen exine formation
namespace: biological_process
def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dhl]
is_a: GO:0010208 ! pollen wall assembly

[Term]
id: GO:0010585
name: glutamine secretion
namespace: biological_process
def: "The controlled release of glutamine by a cell." [PMID:15208395]
is_a: GO:0006868 ! glutamine transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0010586
name: miRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
subset: goslim_drosophila
synonym: "microRNA metabolic process" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0010587
name: miRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
synonym: "microRNA catabolic process" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0010586 ! miRNA metabolic process

[Term]
id: GO:0010588
name: cotyledon vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439]
is_a: GO:0010051 ! xylem and phloem pattern formation
relationship: part_of GO:0048826 ! cotyledon morphogenesis

[Term]
id: GO:0010589
name: leaf proximal/distal pattern formation
namespace: biological_process
def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054]
is_a: GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0010590
name: regulation of septum digestion after cytokinesis
namespace: biological_process
alt_id: GO:1902467
alt_id: GO:2001041
def: "Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "regulation of cell separation after cytokinesis" RELATED []
synonym: "regulation of cell separation following cytokinesis" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of mitotic cytokinetic cell separation" EXACT []
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0000920 ! septum digestion after cytokinesis

[Term]
id: GO:0010591
name: regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902743 ! regulation of lamellipodium organization
relationship: regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010592
name: positive regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "positive regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0010591 ! regulation of lamellipodium assembly
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902745 ! positive regulation of lamellipodium organization
relationship: positively_regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010593
name: negative regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "negative regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0010591 ! regulation of lamellipodium assembly
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902744 ! negative regulation of lamellipodium organization
relationship: negatively_regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010594
name: regulation of endothelial cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010595
name: positive regulation of endothelial cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010596
name: negative regulation of endothelial cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010597
name: green leaf volatile biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163881]
is_a: GO:0019372 ! lipoxygenase pathway

[Term]
id: GO:0010598
name: NAD(P)H dehydrogenase complex (plastoquinone)
namespace: cellular_component
def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0010599
name: lsiRNA processing
namespace: biological_process
def: "A process leading to the generation of a functional long small interfering RNA (lsiRNA). lsiRNAs are class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861, PMID:20687832]
synonym: "primary lsiRNA processing" EXACT []
synonym: "production of lsiRNA involved in RNA interference" RELATED []
synonym: "RNA interference, production of lsiRNA" EXACT [GOC:mah]
is_a: GO:0030422 ! siRNA processing
relationship: part_of GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0010600
name: regulation of auxin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0090354 ! regulation of auxin metabolic process
relationship: regulates GO:0009851 ! auxin biosynthetic process

[Term]
id: GO:0010601
name: positive regulation of auxin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041]
is_a: GO:0010600 ! regulation of auxin biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0090355 ! positive regulation of auxin metabolic process
relationship: positively_regulates GO:0009851 ! auxin biosynthetic process

[Term]
id: GO:0010602
name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process
namespace: biological_process
def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process

[Term]
id: GO:0010603
name: regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0033962 ! P-body assembly

[Term]
id: GO:0010604
name: positive regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: positively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010605
name: negative regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010606
name: positive regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0033962 ! P-body assembly

[Term]
id: GO:0010607
name: negative regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0033962 ! P-body assembly

[Term]
id: GO:0010608
name: post-transcriptional regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]
synonym: "posttranscriptional regulation of gene expression" EXACT []
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0010609
name: mRNA localization resulting in post-transcriptional regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintenance in, a specific location within the cell." [GOC:dph, GOC:tb]
synonym: "mRNA localisation resulting in posttranscriptional regulation of gene expression" EXACT []
synonym: "mRNA localization resulting in posttranscriptional regulation of gene expression" EXACT []
synonym: "posttranscriptional regulation of gene expression by mRNA localisation" EXACT [GOC:mah]
synonym: "posttranscriptional regulation of gene expression by mRNA localization" EXACT []
is_a: GO:0008298 ! intracellular mRNA localization
is_a: GO:0010608 ! post-transcriptional regulation of gene expression

[Term]
id: GO:0010610
name: regulation of mRNA stability involved in response to stress
namespace: biological_process
def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb]
is_a: GO:0043488 ! regulation of mRNA stability
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0010611
name: regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010612
name: regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb]
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010613
name: positive regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010614
name: negative regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010615
name: positive regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014744 ! positive regulation of muscle adaptation
relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010616
name: negative regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014745 ! negative regulation of muscle adaptation
relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010617
name: circadian regulation of calcium ion oscillation
namespace: biological_process
def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000]
synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED []
synonym: "circadian regulation of Ca2+ oscillation" RELATED []
synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED []
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0010618
name: aerenchyma formation
namespace: biological_process
def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0010619
name: adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by glucose binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:signaling, GOC:tb]
synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" EXACT [GOC:dph, GOC:tb]
synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway" EXACT [GOC:signaling]
synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway" EXACT [GOC:mah]
synonym: "glucose-sensing PKA pathway" EXACT []
is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway
relationship: part_of GO:0010255 ! glucose mediated signaling pathway

[Term]
id: GO:0010620
name: negative regulation of transcription by transcription factor catabolism
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
is_a: GO:0045892 ! negative regulation of DNA-templated transcription

[Term]
id: GO:0010621
name: negative regulation of transcription by transcription factor localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb]
synonym: "negative regulation of transcription by transcription factor localisation" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization
is_a: GO:0045892 ! negative regulation of DNA-templated transcription

[Term]
id: GO:0010622
name: specification of ovule identity
namespace: biological_process
def: "The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0048482 ! plant ovule morphogenesis

[Term]
id: GO:0010623
name: programmed cell death involved in cell development
namespace: biological_process
def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure.
synonym: "developmental programmed cell death" BROAD []
synonym: "programmed cell death involved in development" BROAD []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0010624
name: regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0060251 ! regulation of glial cell proliferation
relationship: regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010625
name: positive regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060252 ! positive regulation of glial cell proliferation
relationship: positively_regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010626
name: negative regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060253 ! negative regulation of glial cell proliferation
relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010628
name: positive regulation of gene expression
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
relationship: positively_regulates GO:0010467 ! gene expression

[Term]
id: GO:0010629
name: negative regulation of gene expression
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
synonym: "gene silencing" RELATED []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
relationship: negatively_regulates GO:0010467 ! gene expression

[Term]
id: GO:0010630
name: regulation of transcription, start site selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb]
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process

[Term]
id: GO:0010631
name: epithelial cell migration
namespace: biological_process
def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0090132 ! epithelium migration

[Term]
id: GO:0010632
name: regulation of epithelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010633
name: negative regulation of epithelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010634
name: positive regulation of epithelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010635
name: regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010636
name: positive regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010637
name: negative regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010638
name: positive regulation of organelle organization
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "positive regulation of organelle organisation" EXACT [GOC:mah]
synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010639
name: negative regulation of organelle organization
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of organelle organisation" EXACT [GOC:mah]
synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010640
name: regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010641
name: positive regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010642
name: negative regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010643
name: cell communication by chemical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0007154 ! cell communication

[Term]
id: GO:0010644
name: cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0007154 ! cell communication

[Term]
id: GO:0010645
name: regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
relationship: regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010646
name: regulation of cell communication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007154 ! cell communication

[Term]
id: GO:0010647
name: positive regulation of cell communication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010648
name: negative regulation of cell communication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010649
name: regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
relationship: regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010650
name: positive regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010651
name: negative regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010652
name: positive regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010645 ! regulation of cell communication by chemical coupling
is_a: GO:0010647 ! positive regulation of cell communication
relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010653
name: negative regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010645 ! regulation of cell communication by chemical coupling
is_a: GO:0010648 ! negative regulation of cell communication
relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010654
name: apical cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0010656
name: negative regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "negative regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
relationship: negatively_regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010657
name: muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "muscle cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0010658
name: striated muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "striated muscle cell apoptosis" NARROW []
is_a: GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010659
name: cardiac muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010660
name: regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of muscle cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010661
name: positive regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
relationship: positively_regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010662
name: regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
relationship: regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010663
name: positive regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
relationship: positively_regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010664
name: negative regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010665
name: regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
relationship: regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010666
name: positive regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010667
name: negative regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010668
name: ectodermal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0010669
name: epithelial structure maintenance
namespace: biological_process
def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0010670
name: obsolete positive regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "positive regulation of oxygen and reactive oxygen species metabolic process" EXACT []
is_obsolete: true
consider: GO:2000376
consider: GO:2000379

[Term]
id: GO:0010671
name: obsolete negative regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "negative regulation of oxygen and reactive oxygen species metabolic process" EXACT []
is_obsolete: true
consider: GO:2000375
consider: GO:2000378

[Term]
id: GO:0010672
name: obsolete regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
namespace: biological_process
alt_id: GO:1900401
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:12161753]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of meiosis by regulation of transcription from RNA polymerase II promoter" NARROW []
synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006357
consider: GO:0051321

[Term]
id: GO:0010673
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
namespace: biological_process
alt_id: GO:1900476
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW []
synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah]
synonym: "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0045944
consider: GO:0051321

[Term]
id: GO:0010674
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
namespace: biological_process
alt_id: GO:1900475
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah]
synonym: "positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW []
synonym: "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122
consider: GO:0000278

[Term]
id: GO:0010675
name: obsolete regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is not different from its parent, regulation of carbohydrate metabolic process ; GO:0006109.
is_obsolete: true
replaced_by: GO:0006109

[Term]
id: GO:0010676
name: obsolete positive regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is not different from its parent, positive regulation of carbohydrate metabolic process ; GO:0045913.
is_obsolete: true
replaced_by: GO:0045913

[Term]
id: GO:0010677
name: obsolete negative regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is not different from its parent, negative regulation of carbohydrate metabolic process ; GO:0045912.
is_obsolete: true
replaced_by: GO:0045912

[Term]
id: GO:0010678
name: obsolete negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated
namespace: biological_process
def: "OBSOLETE. Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is represents a GO-CAM model.
synonym: "negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "negative regulation of cellular carbohydrate metabolic process by repression of transcription" EXACT [GOC:bf, GOC:vw]
synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0010679
name: obsolete cinnamic acid biosynthetic process involved in salicylic acid metabolism
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it does not represent a specific pathway.
is_obsolete: true

[Term]
id: GO:0010680
name: obsolete cinnamic acid biosynthetic process involved in coumarin metabolism
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it does not represent a specific pathway.
is_obsolete: true

[Term]
id: GO:0010681
name: obsolete cinnamic acid biosynthetic process involved in stilbene metabolism
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it does not represent a specific pathway.
is_obsolete: true

[Term]
id: GO:0010682
name: obsolete cinnamic acid biosynthetic process involved in flavonoid metabolism
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it does not represent a specific pathway.
is_obsolete: true

[Term]
id: GO:0010683
name: tricyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators]
synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators]
is_a: GO:0006722 ! triterpenoid metabolic process

[Term]
id: GO:0010684
name: tricyclic triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators]
synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process
is_a: GO:0016105 ! triterpenoid catabolic process

[Term]
id: GO:0010685
name: tetracyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators]
synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators]
is_a: GO:0006722 ! triterpenoid metabolic process

[Term]
id: GO:0010686
name: tetracyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators]
synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators]
is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process
is_a: GO:0016104 ! triterpenoid biosynthetic process

[Term]
id: GO:0010688
name: negative regulation of ribosomal protein gene transcription by RNA polymerase II
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II
is_a: GO:0060962 ! regulation of ribosomal protein gene transcription by RNA polymerase II

[Term]
id: GO:0010689
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0010690
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0010691
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II
is_a: GO:0031669 ! cellular response to nutrient levels

[Term]
id: GO:0010692
name: regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0010693
name: negative regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010692 ! regulation of alkaline phosphatase activity
is_a: GO:0010923 ! negative regulation of phosphatase activity

[Term]
id: GO:0010694
name: positive regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010692 ! regulation of alkaline phosphatase activity
is_a: GO:0010922 ! positive regulation of phosphatase activity

[Term]
id: GO:0010695
name: regulation of mitotic spindle pole body separation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0000073 ! initial mitotic spindle pole body separation

[Term]
id: GO:0010696
name: positive regulation of mitotic spindle pole body separation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010695 ! regulation of mitotic spindle pole body separation
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0000073 ! initial mitotic spindle pole body separation

[Term]
id: GO:0010697
name: negative regulation of mitotic spindle pole body separation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010695 ! regulation of mitotic spindle pole body separation
is_a: GO:0010948 ! negative regulation of cell cycle process
relationship: negatively_regulates GO:0000073 ! initial mitotic spindle pole body separation

[Term]
id: GO:0010698
name: acetyltransferase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:23912279]
synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0010700
name: negative regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
relationship: negatively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010701
name: positive regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
relationship: positively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010702
name: obsolete regulation of histolysis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0010703
name: obsolete negative regulation of histolysis
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb]
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0010704
name: meiotic DNA double-strand break processing involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000706 ! meiotic DNA double-strand break processing
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010705
name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000706 ! meiotic DNA double-strand break processing
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010706
name: ganglioside biosynthetic process via lactosylceramide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb]
synonym: "biosynthesis of lactosylceramide precursor to ganglioside" RELATED [GOC:bf, GOC:dph, GOC:tb]
synonym: "ganglioside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf]
synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001574 ! ganglioside biosynthetic process

[Term]
id: GO:0010707
name: globoside biosynthetic process via lactosylceramide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb]
synonym: "biosynthesis of lactosylceramide precursor to globoside" RELATED [GOC:bf, GOC:dph, GOC:tb]
synonym: "globoside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf]
synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001576 ! globoside biosynthetic process

[Term]
id: GO:0010709
name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb]
is_a: GO:0030491 ! heteroduplex formation
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0010710
name: regulation of collagen catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
relationship: regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010711
name: negative regulation of collagen catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
relationship: negatively_regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010712
name: regulation of collagen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010713
name: negative regulation of collagen metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
relationship: negatively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010714
name: positive regulation of collagen metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
relationship: positively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010715
name: regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:1903053 ! regulation of extracellular matrix organization
relationship: regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010716
name: negative regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010717
name: regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010718
name: positive regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010719
name: negative regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010720
name: positive regulation of cell development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: positively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010721
name: negative regulation of cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: negatively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010722
name: regulation of ferrochelatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0010723
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0010039
consider: GO:0045944

[Term]
id: GO:0010724
name: regulation of definitive erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of definitive RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of definitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045646 ! regulation of erythrocyte differentiation
relationship: regulates GO:0060318 ! definitive erythrocyte differentiation

[Term]
id: GO:0010725
name: regulation of primitive erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045646 ! regulation of erythrocyte differentiation
relationship: regulates GO:0060319 ! primitive erythrocyte differentiation

[Term]
id: GO:0010726
name: positive regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010727
name: negative regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010728
name: regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010729
name: positive regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process
is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process
is_a: GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process
relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010730
name: negative regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process
is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process
is_a: GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process
relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010731
name: protein glutathionylation
namespace: biological_process
def: "The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0010732
name: regulation of protein glutathionylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0010731 ! protein glutathionylation

[Term]
id: GO:0010733
name: positive regulation of protein glutathionylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0010732 ! regulation of protein glutathionylation
is_a: GO:0031401 ! positive regulation of protein modification process
relationship: positively_regulates GO:0010731 ! protein glutathionylation

[Term]
id: GO:0010734
name: negative regulation of protein glutathionylation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0010732 ! regulation of protein glutathionylation
is_a: GO:0031400 ! negative regulation of protein modification process
relationship: negatively_regulates GO:0010731 ! protein glutathionylation

[Term]
id: GO:0010735
name: obsolete positive regulation of transcription via serum response element binding
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0010736

[Term]
id: GO:0010736
name: serum response element binding
namespace: molecular_function
def: "Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0010737
name: protein kinase A signaling
namespace: biological_process
def: "An intracellular signaling cassette that starts with the activation of protein kinase A (PKA), and ends with the regulation of a downstream cellular process, e.g. transcription. The PKA catalytic subunit (PKA-C) is normally present in a complex with its regulatory subunit, PKA-R. The inhibitory action of PKA-R is released upon cAMP binding, which results in the activation of PKA-C." [PMID:35252178, PMID:36431013]
synonym: "PKA signaling cascade" RELATED [GOC:dph, GOC:tb]
synonym: "protein kinase A signal transduction" EXACT [GOC:signaling]
synonym: "protein kinase A signaling cascade" RELATED [GOC:signaling]
synonym: "protein kinase A signalling cascade" RELATED [GOC:mah]
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0010738
name: regulation of protein kinase A signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of protein kinase A signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of protein kinase A signalling cascade" RELATED [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0010737 ! protein kinase A signaling

[Term]
id: GO:0010739
name: positive regulation of protein kinase A signaling
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of protein kinase A signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of protein kinase A signalling cascade" RELATED [GOC:mah]
is_a: GO:0010738 ! regulation of protein kinase A signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0010737 ! protein kinase A signaling

[Term]
id: GO:0010742
name: macrophage derived foam cell differentiation
namespace: biological_process
def: "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0090077 ! foam cell differentiation

[Term]
id: GO:0010743
name: regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010744
name: positive regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010745
name: negative regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010746
name: regulation of long-chain fatty acid import across plasma membrane
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:BHF, GOC:dph, GOC:tb]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "regulation of plasma membrane long-chain fatty acid transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell
relationship: regulates GO:0015911 ! long-chain fatty acid import across plasma membrane

[Term]
id: GO:0010747
name: positive regulation of long-chain fatty acid import across plasma membrane
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:BHF, GOC:dph, GOC:tb]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "positive regulation of plasma membrane long-chain fatty acid transport" EXACT []
is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0140214 ! positive regulation of long-chain fatty acid import into cell
relationship: positively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane

[Term]
id: GO:0010748
name: negative regulation of long-chain fatty acid import across plasma membrane
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of plasma membrane long-chain fatty acid transport" EXACT []
is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0140213 ! negative regulation of long-chain fatty acid import into cell
relationship: negatively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane

[Term]
id: GO:0010749
name: regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010750
name: positive regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010751
name: negative regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010752
name: regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010753
name: positive regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010754
name: negative regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010755
name: regulation of plasminogen activation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0070613 ! regulation of protein processing
relationship: regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010756
name: positive regulation of plasminogen activation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010755 ! regulation of plasminogen activation
is_a: GO:0010954 ! positive regulation of protein processing
relationship: positively_regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010757
name: negative regulation of plasminogen activation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010755 ! regulation of plasminogen activation
is_a: GO:0010955 ! negative regulation of protein processing
relationship: negatively_regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010758
name: regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:1905521 ! regulation of macrophage migration
relationship: regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010759
name: positive regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:1905523 ! positive regulation of macrophage migration
relationship: positively_regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010760
name: negative regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
is_a: GO:1905522 ! negative regulation of macrophage migration
relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010761
name: fibroblast migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0010762
name: regulation of fibroblast migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010763
name: positive regulation of fibroblast migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010764
name: negative regulation of fibroblast migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010765
name: positive regulation of sodium ion transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
relationship: positively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010766
name: negative regulation of sodium ion transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
relationship: negatively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010767
name: obsolete regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0034644

[Term]
id: GO:0010768
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:0034644

[Term]
id: GO:0010769
name: obsolete regulation of cell morphogenesis involved in differentiation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
comment: This term is equivalent to regulation of cell morphogenesis.
is_obsolete: true
replaced_by: GO:0022604

[Term]
id: GO:0010770
name: positive regulation of cell morphogenesis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0022604 ! regulation of cell morphogenesis
relationship: positively_regulates GO:0000902 ! cell morphogenesis

[Term]
id: GO:0010771
name: negative regulation of cell morphogenesis
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0022604 ! regulation of cell morphogenesis
relationship: negatively_regulates GO:0000902 ! cell morphogenesis

[Term]
id: GO:0010772
name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000707 ! meiotic DNA recombinase assembly
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010773
name: meiotic DNA recombinase assembly involved in meiotic gene conversion
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000707 ! meiotic DNA recombinase assembly
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010774
name: meiotic strand invasion involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000708 ! meiotic strand invasion
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010775
name: meiotic strand invasion involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0000708 ! meiotic strand invasion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010776
name: meiotic mismatch repair involved in meiotic gene conversion
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000710 ! meiotic mismatch repair
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010777
name: meiotic mismatch repair involved in reciprocal meiotic recombination
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000710 ! meiotic mismatch repair
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010778
name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination
namespace: biological_process
def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000711 ! meiotic DNA repair synthesis
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010779
name: meiotic DNA repair synthesis involved in meiotic gene conversion
namespace: biological_process
def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000711 ! meiotic DNA repair synthesis
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010780
name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0042138 ! meiotic DNA double-strand break formation
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010781
name: meiotic DNA double-strand break formation involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0042138 ! meiotic DNA double-strand break formation
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010782
name: proboscis morphogenesis, labial disc-derived
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007454 ! labial disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010783
name: proboscis morphogenesis, eye-antennal disc-derived
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010784
name: proboscis morphogenesis, clypeo-labral disc-derived
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010785
name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048202 ! clathrin coating of Golgi vesicle
relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome

[Term]
id: GO:0010786
name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048202 ! clathrin coating of Golgi vesicle
relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome

[Term]
id: GO:0010787
name: COPI coating of Golgi vesicle, inter-Golgi cisterna
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048205 ! COPI coating of Golgi vesicle
relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna

[Term]
id: GO:0010788
name: COPI coating of Golgi vesicle, cis-Golgi to rough ER
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048205 ! COPI coating of Golgi vesicle
relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough endoplasmic reticulum

[Term]
id: GO:0010789
name: meiotic sister chromatid cohesion involved in meiosis I
namespace: biological_process
def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb]
is_a: GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0010790
name: meiotic sister chromatid cohesion involved in meiosis II
namespace: biological_process
def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb]
is_a: GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0010791
name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb]
is_a: GO:0000729 ! DNA double-strand break processing
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0010792
name: DNA double-strand break processing involved in repair via single-strand annealing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb]
is_a: GO:0000729 ! DNA double-strand break processing
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0010793
name: regulation of mRNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0046831 ! regulation of RNA export from nucleus
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
relationship: regulates GO:0006406 ! mRNA export from nucleus

[Term]
id: GO:0010794
name: regulation of dolichol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0019408 ! dolichol biosynthetic process

[Term]
id: GO:0010795
name: regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
relationship: regulates GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0010796
name: obsolete regulation of multivesicular body size
namespace: biological_process
def: "OBSOLETE. Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb]
comment: The reason for obsoletion is that this term represents an assay and not a real GO process.
is_obsolete: true

[Term]
id: GO:0010797
name: obsolete regulation of multivesicular body size involved in endosome transport
namespace: biological_process
def: "OBSOLETE. Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represents an assay and not a real GO process.
is_obsolete: true

[Term]
id: GO:0010798
name: obsolete regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism
namespace: biological_process
def: "OBSOLETE. Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represents an assay and not a real GO process.
is_obsolete: true

[Term]
id: GO:0010799
name: regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0001932 ! regulation of protein phosphorylation
relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010800
name: positive regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation
relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010801
name: negative regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation
relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010803
name: regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb]
synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:0010804
name: negative regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb]
synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway
relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:0010807
name: regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]
subset: goslim_synapse
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010808
name: positive regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]
is_a: GO:0010807 ! regulation of synaptic vesicle priming
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
relationship: positively_regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010809
name: negative regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmvs, GOC:tb, PMID:15489511]
is_a: GO:0010807 ! regulation of synaptic vesicle priming
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis
relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010810
name: regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010811
name: positive regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
relationship: positively_regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010812
name: negative regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0010810 ! regulation of cell-substrate adhesion
relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010813
name: neuropeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0010814
name: substance P catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:BHF, GOC:rl]
is_a: GO:0010813 ! neuropeptide catabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0010815
name: bradykinin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl]
is_a: GO:0009056 ! catabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0010816
name: calcitonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl]
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0010817
name: regulation of hormone levels
namespace: biological_process
def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0010818
name: T cell chemotaxis
namespace: biological_process
def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb]
synonym: "T-cell chemotaxis" EXACT [CL:0000084]
is_a: GO:0048247 ! lymphocyte chemotaxis
is_a: GO:0072678 ! T cell migration

[Term]
id: GO:0010819
name: regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000404 ! regulation of T cell migration
relationship: regulates GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0010820
name: positive regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010819 ! regulation of T cell chemotaxis
is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis
is_a: GO:2000406 ! positive regulation of T cell migration
relationship: positively_regulates GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0010821
name: regulation of mitochondrion organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007005 ! mitochondrion organization

[Term]
id: GO:0010822
name: obsolete positive regulation of mitochondrion organization
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that the meaning of the term is ambiguous.
synonym: "positive regulation of mitochondrion organisation" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0010823
name: obsolete negative regulation of mitochondrion organization
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
synonym: "negative regulation of mitochondrion organisation" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0010824
name: regulation of centrosome duplication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0046605 ! regulation of centrosome cycle
relationship: regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010825
name: positive regulation of centrosome duplication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0010824 ! regulation of centrosome duplication
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010826
name: negative regulation of centrosome duplication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0010824 ! regulation of centrosome duplication
is_a: GO:0046606 ! negative regulation of centrosome cycle
relationship: negatively_regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010827
name: regulation of D-glucose transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
synonym: "regulation of glucose transmembrane transport" EXACT []
synonym: "regulation of glucose transport" RELATED []
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:1904659 ! D-glucose transmembrane transport

[Term]
id: GO:0010828
name: positive regulation of D-glucose transmembrane transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of glucose transmembrane transport" EXACT []
synonym: "positive regulation of glucose transport" RELATED []
is_a: GO:0010827 ! regulation of D-glucose transmembrane transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
relationship: positively_regulates GO:1904659 ! D-glucose transmembrane transport

[Term]
id: GO:0010829
name: negative regulation of D-glucose transmembrane transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of glucose transmembrane transport" EXACT []
synonym: "negative regulation of glucose transport" RELATED []
is_a: GO:0010827 ! regulation of D-glucose transmembrane transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
relationship: negatively_regulates GO:1904659 ! D-glucose transmembrane transport

[Term]
id: GO:0010830
name: regulation of myotube differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
relationship: regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010831
name: positive regulation of myotube differentiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
relationship: positively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010832
name: negative regulation of myotube differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
relationship: negatively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010833
name: telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb]
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0010834
name: obsolete telomere maintenance via telomere shortening
namespace: biological_process
def: "OBSOLETE. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it represents a phenotype.
synonym: "telomere maintenance via telomere shortening" EXACT []
is_obsolete: true
consider: GO:1903824

[Term]
id: GO:0010835
name: regulation of protein ADP-ribosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0010836
name: negative regulation of protein ADP-ribosylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "negative regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0010835 ! regulation of protein ADP-ribosylation
is_a: GO:0051348 ! negative regulation of transferase activity

[Term]
id: GO:0010837
name: regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010838
name: positive regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0010837 ! regulation of keratinocyte proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
relationship: positively_regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010839
name: negative regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0010837 ! regulation of keratinocyte proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
relationship: negatively_regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010840
name: regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:dph, GOC:tb]
is_a: GO:0042749 ! regulation of circadian sleep/wake cycle
relationship: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness

[Term]
id: GO:0010841
name: positive regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0048520 ! positive regulation of behavior
relationship: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness

[Term]
id: GO:0010842
name: retina layer formation
namespace: biological_process
def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266]
synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb]
synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0010843
name: obsolete promoter binding
namespace: molecular_function
def: "OBSOLETE. Binding to a regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery." [GOC:dph, GOC:tb, SO:0000167]
comment: This term was made obsolete because the word "promoter" is used ambiguously in the literature. It sometimes is used to refer specifically to the "core promoter" region recognized by the basal transcription machinery, and other times is used to refer to a larger regulatory region composed of the core promoter and also the regulatory region adjacent (proximal) to the core promoter. The core promoter proximal region is typically recognized by "regulatory transcription factors", such as Gal4 in S. cerevisiae.
synonym: "DNA binding, transcription promoter" EXACT [GOC:dph, GOC:tb]
synonym: "promoter binding" EXACT []
is_obsolete: true
consider: GO:0000976
consider: GO:0001046

[Term]
id: GO:0010844
name: recombination hotspot binding
namespace: molecular_function
def: "Binding to a genomic region which promotes recombination." [GOC:dph, GOC:tb]
synonym: "DNA binding, recombination hotspot" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0010845
name: positive regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
synonym: "positive regulation of meiotic recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:0045911 ! positive regulation of DNA recombination
relationship: positively_regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010846
name: activation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
synonym: "activation of meiotic recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination

[Term]
id: GO:0010847
name: obsolete regulation of chromatin assembly
namespace: biological_process
def: "OBSOLETE. Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb]
comment: This term was obsoleted because 'chromatin assembly' was merged into 'chromatin organization'.
is_obsolete: true
replaced_by: GO:0006325

[Term]
id: GO:0010848
name: obsolete regulation of chromatin disassembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb]
comment: This term has been obsoleted because this process doesn't happen independently from assembly and is always tied to chromatin remodeling.
is_obsolete: true

[Term]
id: GO:0010849
name: regulation of proton-transporting ATPase activity, rotational mechanism
namespace: biological_process
def: "Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of V-type ATPase activity" BROAD [GOC:dph, GOC:tb]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0043462 ! regulation of ATP-dependent activity

[Term]
id: GO:0010850
name: regulation of blood pressure by chemoreceptor signaling pathway
namespace: biological_process
def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb]
synonym: "regulation of blood pressure by chemoreceptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0010851
name: cyclase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0010852
name: cyclase inhibitor activity
namespace: molecular_function
def: "Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010853
name: cyclase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010854
name: adenylate cyclase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of adenylate cyclase." [GOC:dph, GOC:tb]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010855
name: adenylate cyclase inhibitor activity
namespace: molecular_function
def: "Binds to and decreases the activity of adenylate cyclase." [GOC:dph, GOC:tb]
xref: Reactome:R-HSA-400097 "G-beta:G-gamma inhibits Adenylate cyclase"
is_a: GO:0010852 ! cyclase inhibitor activity
is_a: GO:0010854 ! adenylate cyclase regulator activity

[Term]
id: GO:0010856
name: adenylate cyclase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of adenylate cyclase." [GOC:dph, GOC:tb]
xref: Reactome:R-HSA-163617 "G alpha (s) activates adenylate cyclase"
xref: Reactome:R-HSA-381704 "G(s):GTP activates Adenylyl cyclase"
is_a: GO:0010853 ! cyclase activator activity
is_a: GO:0010854 ! adenylate cyclase regulator activity

[Term]
id: GO:0010857
name: obsolete calcium-dependent protein kinase activity
namespace: molecular_function
def: "OBSOLETE. Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is an unnecessary grouping class. All calcium-dependent protein kinases are serine/threonine protein kinases.
is_obsolete: true
consider: GO:0004683
consider: GO:0004699

[Term]
id: GO:0010858
name: calcium-dependent protein kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner." [GOC:dph, GOC:tb]
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0010859
name: calcium-dependent cysteine-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner." [GOC:dph, GOC:tb]
is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity

[Term]
id: GO:0010860
name: obsolete proteasome regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:dph, GOC:tb]
comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
synonym: "proteasome regulator activity" EXACT []
is_obsolete: true
consider: GO:0061135
consider: GO:0061136

[Term]
id: GO:0010862
name: obsolete positive regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0030295
consider: GO:0060391

[Term]
id: GO:0010863
name: obsolete positive regulation of phospholipase C activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate of phospholipase C activity." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0010864
name: obsolete positive regulation of protein histidine kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of protein histidine kinase activity." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0010865
name: stipule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms." [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0010866
name: regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010867
name: positive regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "positive regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010866 ! regulation of triglyceride biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0090208 ! positive regulation of triglyceride metabolic process
relationship: positively_regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010868
name: negative regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "negative regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010866 ! regulation of triglyceride biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0090209 ! negative regulation of triglyceride metabolic process
relationship: negatively_regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010869
name: obsolete regulation of receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
is_obsolete: true

[Term]
id: GO:0010870
name: obsolete positive regulation of receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
is_obsolete: true

[Term]
id: GO:0010871
name: obsolete negative regulation of receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
is_obsolete: true

[Term]
id: GO:0010872
name: obsolete regulation of cholesterol esterification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008203

[Term]
id: GO:0010873
name: obsolete positive regulation of cholesterol esterification
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008203

[Term]
id: GO:0010874
name: regulation of cholesterol efflux
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: regulates GO:0033344 ! cholesterol efflux

[Term]
id: GO:0010875
name: positive regulation of cholesterol efflux
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010874 ! regulation of cholesterol efflux
is_a: GO:0032376 ! positive regulation of cholesterol transport
relationship: positively_regulates GO:0033344 ! cholesterol efflux

[Term]
id: GO:0010876
name: lipid localization
namespace: biological_process
def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "lipid localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0010877
name: lipid transport involved in lipid storage
namespace: biological_process
def: "The directed movement of lipids into cells that is part of their accumulation and maintenance." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0006869 ! lipid transport
relationship: part_of GO:0019915 ! lipid storage

[Term]
id: GO:0010878
name: cholesterol storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb]
is_a: GO:0019915 ! lipid storage

[Term]
id: GO:0010879
name: cholesterol transport involved in cholesterol storage
namespace: biological_process
def: "The directed movement of cholesterol into cells that is part of their accumulation and maintenance." [GOC:dph, GOC:tb]
is_a: GO:0010877 ! lipid transport involved in lipid storage
is_a: GO:0030301 ! cholesterol transport
relationship: part_of GO:0010878 ! cholesterol storage

[Term]
id: GO:0010880
name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
relationship: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

[Term]
id: GO:0010881
name: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
is_a: GO:0010882 ! regulation of cardiac muscle contraction by calcium ion signaling

[Term]
id: GO:0010882
name: regulation of cardiac muscle contraction by calcium ion signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah]
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0055117 ! regulation of cardiac muscle contraction

[Term]
id: GO:0010883
name: regulation of lipid storage
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010884
name: positive regulation of lipid storage
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
is_a: GO:1905954 ! positive regulation of lipid localization
relationship: positively_regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010885
name: regulation of cholesterol storage
namespace: biological_process
def: "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
relationship: regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010886
name: positive regulation of cholesterol storage
namespace: biological_process
def: "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010884 ! positive regulation of lipid storage
is_a: GO:0010885 ! regulation of cholesterol storage
relationship: positively_regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010887
name: negative regulation of cholesterol storage
namespace: biological_process
def: "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010885 ! regulation of cholesterol storage
is_a: GO:0010888 ! negative regulation of lipid storage
relationship: negatively_regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010888
name: negative regulation of lipid storage
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
is_a: GO:1905953 ! negative regulation of lipid localization
relationship: negatively_regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010889
name: regulation of triglyceride storage
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "regulation of sequestering of triglyceride" EXACT []
synonym: "regulation of triacylglycerol sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
relationship: regulates GO:0030730 ! triglyceride storage

[Term]
id: GO:0010890
name: positive regulation of triglyceride storage
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "positive regulation of sequestering of triglyceride" EXACT []
synonym: "positive regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010884 ! positive regulation of lipid storage
is_a: GO:0010889 ! regulation of triglyceride storage
relationship: positively_regulates GO:0030730 ! triglyceride storage

[Term]
id: GO:0010891
name: negative regulation of triglyceride storage
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "negative regulation of sequestering of triglyceride" EXACT []
synonym: "negative regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010888 ! negative regulation of lipid storage
is_a: GO:0010889 ! regulation of triglyceride storage
relationship: negatively_regulates GO:0030730 ! triglyceride storage

[Term]
id: GO:0010892
name: positive regulation of mitochondrial translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0070131 ! positive regulation of mitochondrial translation

[Term]
id: GO:0010893
name: positive regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: positively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010894
name: negative regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010895
name: negative regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:tb]
is_a: GO:0032443 ! regulation of ergosterol biosynthetic process
is_a: GO:0106119 ! negative regulation of sterol biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0010896
name: regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010897
name: negative regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "negative regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0010896 ! regulation of triglyceride catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0090209 ! negative regulation of triglyceride metabolic process
relationship: negatively_regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010898
name: positive regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "positive regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0010896 ! regulation of triglyceride catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0090208 ! positive regulation of triglyceride metabolic process
relationship: positively_regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010899
name: regulation of phosphatidylcholine catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb]
is_a: GO:0060696 ! regulation of phospholipid catabolic process
is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process
relationship: regulates GO:0034638 ! phosphatidylcholine catabolic process

[Term]
id: GO:0010900
name: negative regulation of phosphatidylcholine catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb]
is_a: GO:0010899 ! regulation of phosphatidylcholine catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0150174 ! negative regulation of phosphatidylcholine metabolic process
relationship: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process

[Term]
id: GO:0010901
name: regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "regulation of very-low-density lipoprotein particle remodelling" EXACT [GOC:tb]
synonym: "regulation of VLDL remodeling" EXACT [GOC:tb]
synonym: "regulation of VLDL remodelling" EXACT []
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010902
name: positive regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "positive regulation of very-low-density lipoprotein particle remodelling" EXACT []
synonym: "positive regulation of VLDL remodeling" EXACT [GOC:tb]
synonym: "positive regulation of VLDL remodelling" EXACT []
is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010903
name: negative regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "negative regulation of very-low-density lipoprotein particle remodelling" EXACT []
synonym: "negative regulation of VLDL remodeling" EXACT [GOC:tb]
synonym: "negative regulation of VLDL remodelling" EXACT []
is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010904
name: regulation of UDP-glucose catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb]
synonym: "regulation of UDP-glucose catabolism" EXACT [GOC:tb]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0006258 ! UDP-alpha-D-glucose catabolic process

[Term]
id: GO:0010905
name: negative regulation of UDP-glucose catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb]
synonym: "negative regulation of UDP-glucose catabolism" EXACT [GOC:tb]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010904 ! regulation of UDP-glucose catabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006258 ! UDP-alpha-D-glucose catabolic process

[Term]
id: GO:0010906
name: regulation of glucose metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010907
name: positive regulation of glucose metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010908
name: regulation of heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0010909
name: positive regulation of heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb]
is_a: GO:0010908 ! regulation of heparan sulfate proteoglycan biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1902730 ! positive regulation of proteoglycan biosynthetic process
relationship: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0010910
name: obsolete positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0010911
name: regulation of isomerase activity
namespace: biological_process
def: "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0010912
name: positive regulation of isomerase activity
namespace: biological_process
def: "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010911 ! regulation of isomerase activity
is_a: GO:0043085 ! positive regulation of catalytic activity

[Term]
id: GO:0010913
name: regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0045461 ! sterigmatocystin biosynthetic process

[Term]
id: GO:0010914
name: positive regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb]
is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
relationship: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process

[Term]
id: GO:0010915
name: regulation of very-low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
relationship: regulates GO:0034447 ! very-low-density lipoprotein particle clearance

[Term]
id: GO:0010916
name: negative regulation of very-low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
relationship: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance

[Term]
id: GO:0010917
name: negative regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]
synonym: "reduction of mitochondrial membrane potential" EXACT [GOC:rph]
is_a: GO:0045837 ! negative regulation of membrane potential
is_a: GO:0051881 ! regulation of mitochondrial membrane potential

[Term]
id: GO:0010918
name: positive regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]
synonym: "elevation of mitochondrial membrane potential" EXACT [GOC:rph]
is_a: GO:0045838 ! positive regulation of membrane potential
is_a: GO:0051881 ! regulation of mitochondrial membrane potential

[Term]
id: GO:0010919
name: regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0010920
name: negative regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb]
synonym: "negative regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0010921
name: regulation of phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing phosphate." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0010922
name: positive regulation of phosphatase activity
namespace: biological_process
def: "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010921 ! regulation of phosphatase activity
is_a: GO:0035306 ! positive regulation of dephosphorylation
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0010923
name: negative regulation of phosphatase activity
namespace: biological_process
def: "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010921 ! regulation of phosphatase activity
is_a: GO:0035305 ! negative regulation of dephosphorylation
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0010924
name: regulation of inositol-polyphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0010925
name: positive regulation of inositol-polyphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0010924 ! regulation of inositol-polyphosphate 5-phosphatase activity

[Term]
id: GO:0010926
name: obsolete anatomical structure formation
namespace: biological_process
def: "OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that the term is confusing - it sounds developmental and has a developmental sounding def, but it is not a child of developmental process and its children included 'cellular component assembly'. The term was created to group together 'cellular component assembly' and 'anatomical structure formation involved in morphogenesis', but we no longer feel that this grouping is useful.
synonym: "anatomical structure formation" EXACT []
is_obsolete: true
consider: GO:0022607
consider: GO:0048646

[Term]
id: GO:0010927
name: cellular component assembly involved in morphogenesis
namespace: biological_process
def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0032989 ! cellular anatomical entity morphogenesis

[Term]
id: GO:0010928
name: regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
synonym: "regulation of auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0009734 ! auxin-activated signaling pathway

[Term]
id: GO:0010929
name: positive regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
synonym: "positive regulation of auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
relationship: positively_regulates GO:0009734 ! auxin-activated signaling pathway

[Term]
id: GO:0010930
name: negative regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
synonym: "negative regulation of auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
relationship: negatively_regulates GO:0009734 ! auxin-activated signaling pathway

[Term]
id: GO:0010931
name: macrophage tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0010932
name: regulation of macrophage tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of macrophage tolerance induction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0010931 ! macrophage tolerance induction

[Term]
id: GO:0010933
name: positive regulation of macrophage tolerance induction
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0010932 ! regulation of macrophage tolerance induction
relationship: positively_regulates GO:0010931 ! macrophage tolerance induction

[Term]
id: GO:0010934
name: macrophage cytokine production
namespace: biological_process
def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0010935
name: regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: regulates GO:0010934 ! macrophage cytokine production

[Term]
id: GO:0010936
name: negative regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0010935 ! regulation of macrophage cytokine production
relationship: negatively_regulates GO:0010934 ! macrophage cytokine production

[Term]
id: GO:0010937
name: regulation of cytoplasmic microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb]
is_a: GO:0031114 ! regulation of microtubule depolymerization
relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization

[Term]
id: GO:0010938
name: cytoplasmic microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0010939
name: obsolete regulation of necrotic cell death
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998]
comment: This term was made obsolete because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0010940
name: obsolete positive regulation of necrotic cell death
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998]
comment: This term was obsoleted because it represent a phenotype.
is_obsolete: true

[Term]
id: GO:0010941
name: obsolete regulation of cell death
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represent an assay and not a GO process.
is_obsolete: true

[Term]
id: GO:0010942
name: obsolete positive regulation of cell death
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represent an assay and not a GO process.
is_obsolete: true

[Term]
id: GO:0010943
name: NADPH pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H2O = NMNH + ADP." [GOC:tb, PMID:12790796, RHEA:60820]
xref: RHEA:60820
is_a: GO:0004551 ! dinucleotide phosphatase activity

[Term]
id: GO:0010944
name: negative regulation of transcription by competitive promoter binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb]
is_a: GO:0045892 ! negative regulation of DNA-templated transcription

[Term]
id: GO:0010945
name: coenzyme A diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate." [PMID:10922370, PMID:16185196]
synonym: "CoA diphosphatase activity" RELATED []
synonym: "CoA pyrophosphatase activity" RELATED []
synonym: "coenzyme A pyrophosphatase activity" RELATED []
xref: https://github.com/geneontology/go-ontology/issues/28938
xref: Reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT"
xref: Reactome:R-HSA-6810474 "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT"
xref: Reactome:R-HSA-9837354 "NUDT8 hydrolyzes CoA-SH to PPANT"
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0010946
name: regulation of meiotic joint molecule formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0000709 ! meiotic joint molecule formation

[Term]
id: GO:0010947
name: negative regulation of meiotic joint molecule formation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0010946 ! regulation of meiotic joint molecule formation
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0000709 ! meiotic joint molecule formation

[Term]
id: GO:0010948
name: negative regulation of cell cycle process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045786 ! negative regulation of cell cycle
relationship: negatively_regulates GO:0022402 ! cell cycle process

[Term]
id: GO:0010949
name: negative regulation of intestinal phytosterol absorption
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:1904730 ! negative regulation of intestinal lipid absorption
relationship: negatively_regulates GO:0060752 ! intestinal phytosterol absorption

[Term]
id: GO:0010950
name: positive regulation of endopeptidase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:0052548 ! regulation of endopeptidase activity

[Term]
id: GO:0010951
name: negative regulation of endopeptidase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
subset: goslim_chembl
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:0052548 ! regulation of endopeptidase activity

[Term]
id: GO:0010952
name: positive regulation of peptidase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:0010954
name: positive regulation of protein processing
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
synonym: "positive regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf]
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0070613 ! regulation of protein processing
is_a: GO:1903319 ! positive regulation of protein maturation
relationship: positively_regulates GO:0016485 ! protein processing

[Term]
id: GO:0010955
name: negative regulation of protein processing
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
synonym: "negative regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf]
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0070613 ! regulation of protein processing
is_a: GO:1903318 ! negative regulation of protein maturation
relationship: negatively_regulates GO:0016485 ! protein processing

[Term]
id: GO:0010956
name: negative regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010957 ! negative regulation of vitamin D biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process

[Term]
id: GO:0010957
name: negative regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
relationship: negatively_regulates GO:0042368 ! vitamin D biosynthetic process

[Term]
id: GO:0010958
name: regulation of amino acid import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb]
synonym: "regulation of amino acid import" BROAD []
is_a: GO:1903789 ! regulation of amino acid transmembrane transport
relationship: regulates GO:0089718 ! amino acid import across plasma membrane

[Term]
id: GO:0010959
name: regulation of metal ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0043269 ! regulation of monoatomic ion transport
relationship: regulates GO:0030001 ! metal ion transport

[Term]
id: GO:0010960
name: magnesium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0010961
name: intracellular magnesium ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of magnesium ions within a cell." [GOC:dph, GOC:tb]
synonym: "cellular magnesium ion homeostasis" EXACT []
is_a: GO:0010960 ! magnesium ion homeostasis
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis

[Term]
id: GO:0010962
name: regulation of glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0010964
name: regulation of regulatory ncRNA-mediated heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small non-coding RNA-mediated heterochromatin formation." [GOC:dph, GOC:tb]
synonym: "regulation of chromatin silencing by small RNA" NARROW []
synonym: "regulation of heterochromatin assembly by small RNA" NARROW []
synonym: "regulation of ncRNA-mediated heterochromatin formation" EXACT []
synonym: "regulation of RNAi-mediated heterochromatin assembly" EXACT []
synonym: "regulation of small non-coding RNA-mediated heterochromatin formation" NARROW []
is_a: GO:0031445 ! regulation of heterochromatin formation
is_a: GO:0060966 ! regulation of gene silencing by regulatory ncRNA
relationship: regulates GO:0031048 ! regulatory ncRNA-mediated heterochromatin formation

[Term]
id: GO:0010965
name: regulation of mitotic sister chromatid separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb]
is_a: GO:1905818 ! regulation of chromosome separation
relationship: regulates GO:0051306 ! mitotic sister chromatid separation

[Term]
id: GO:0010966
name: regulation of phosphate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0006817 ! phosphate ion transport

[Term]
id: GO:0010967
name: regulation of polyamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [GOC:dph, GOC:tb]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006596 ! polyamine biosynthetic process

[Term]
id: GO:0010968
name: regulation of microtubule nucleation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0031113 ! regulation of microtubule polymerization
relationship: regulates GO:0007020 ! microtubule nucleation

[Term]
id: GO:0010969
name: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
relationship: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0010970
name: transport along microtubule
namespace: biological_process
def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph]
synonym: "microtubule-based transport" BROAD []
synonym: "movement along microtubule" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0099111 ! microtubule-based transport

[Term]
id: GO:0010971
name: positive regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
alt_id: GO:0031662
def: "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]
synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle" RELATED []
synonym: "positive regulation of mitotic entry" EXACT [GOC:mah]
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition
relationship: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0010972
name: negative regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
synonym: "negative regulation of mitotic entry" EXACT [GOC:vw]
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition
relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0010973
name: positive regulation of division septum assembly
namespace: biological_process
alt_id: GO:1901912
alt_id: GO:1902470
def: "Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "positive regulation of division septum formation" EXACT []
synonym: "positive regulation of division septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic division septum assembly" EXACT [GOC:TermGenie]
is_a: GO:0032955 ! regulation of division septum assembly
is_a: GO:1901893 ! positive regulation of cell septum assembly
relationship: positively_regulates GO:0000917 ! division septum assembly

[Term]
id: GO:0010974
name: negative regulation of division septum assembly
namespace: biological_process
alt_id: GO:1901139
alt_id: GO:1902469
def: "Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "inhibition of division septum assembly involved in cell cycle cytokinesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of division septum formation" EXACT []
is_a: GO:0032955 ! regulation of division septum assembly
is_a: GO:1901892 ! negative regulation of cell septum assembly
relationship: negatively_regulates GO:0000917 ! division septum assembly

[Term]
id: GO:0010975
name: regulation of neuron projection development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "regulation of neurite development" NARROW [GOC:mah]
synonym: "regulation of neurite formation" NARROW [GOC:mah]
synonym: "regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
relationship: regulates GO:0031175 ! neuron projection development

[Term]
id: GO:0010976
name: positive regulation of neuron projection development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "positive regulation of neurite development" NARROW [GOC:mah]
synonym: "positive regulation of neurite formation" NARROW [GOC:mah]
synonym: "positive regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031346 ! positive regulation of cell projection organization
relationship: positively_regulates GO:0031175 ! neuron projection development

[Term]
id: GO:0010977
name: negative regulation of neuron projection development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "growth cone collapse" RELATED [GOC:pr]
synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "negative regulation of neurite development" NARROW [GOC:mah]
synonym: "negative regulation of neurite formation" NARROW [GOC:mah]
synonym: "negative regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031345 ! negative regulation of cell projection organization
relationship: negatively_regulates GO:0031175 ! neuron projection development

[Term]
id: GO:0010978
name: obsolete gene silencing involved in chronological cell aging
namespace: biological_process
def: "OBSOLETE. Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jp, GOC:tb]
comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process.
is_obsolete: true
consider: GO:0044838
consider: GO:0090398

[Term]
id: GO:0010979
name: regulation of vitamin D 24-hydroxylase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0010980
name: positive regulation of vitamin D 24-hydroxylase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010979 ! regulation of vitamin D 24-hydroxylase activity
is_a: GO:0032770 ! positive regulation of monooxygenase activity

[Term]
id: GO:0010981
name: regulation of cell wall macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:tb]
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0010982
name: regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
relationship: regulates GO:0034384 ! high-density lipoprotein particle clearance

[Term]
id: GO:0010983
name: positive regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance
is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance
relationship: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance

[Term]
id: GO:0010984
name: regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0010985
name: negative regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0010986
name: positive regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0010987
name: negative regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
relationship: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance

[Term]
id: GO:0010988
name: regulation of low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
relationship: regulates GO:0034383 ! low-density lipoprotein particle clearance

[Term]
id: GO:0010989
name: negative regulation of low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance
relationship: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance

[Term]
id: GO:0010990
name: obsolete regulation of SMAD protein complex assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a readout for regulation of SMAD protein signal transduction ; GO:0060390.
is_obsolete: true
consider: GO:0060390

[Term]
id: GO:0010991
name: obsolete negative regulation of SMAD protein complex assembly
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a readout for negative regulation of SMAD protein signal transduction ; GO:0060392.
is_obsolete: true
consider: GO:0060392

[Term]
id: GO:0010992
name: ubiquitin recycling
namespace: biological_process
alt_id: GO:0010993
def: "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates." [GOC:BHF, GOC:dph, GOC:tb, PMID:19410548]
synonym: "regulation of ubiquitin homeostasis" NARROW []
synonym: "ubiquitin homeostasis" RELATED []
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0010994
name: free ubiquitin chain polymerization
namespace: biological_process
def: "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051258 ! protein polymerization
relationship: part_of GO:0010992 ! ubiquitin recycling

[Term]
id: GO:0010995
name: free ubiquitin chain depolymerization
namespace: biological_process
def: "The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0010992 ! ubiquitin recycling

[Term]
id: GO:0010996
name: response to auditory stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]
synonym: "response to sound" EXACT [GOC:dph, GOC:sl, GOC:tb]
synonym: "response to sound stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0010997
name: anaphase-promoting complex binding
namespace: molecular_function
def: "Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "APC binding" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0010998
name: regulation of translational initiation by eIF2 alpha phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]
comment: Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'.
subset: gocheck_obsoletion_candidate
synonym: "eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf]
synonym: "regulation of translational initiation by eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf]
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0010999
name: regulation of eIF2 alpha phosphorylation by heme
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation

[Term]
id: GO:0011000
name: replication fork arrest at mating type locus
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb]
is_a: GO:0043111 ! replication fork arrest

[Term]
id: GO:0012501
name: programmed cell death
namespace: biological_process
alt_id: GO:0016244
def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
synonym: "caspase-independent apoptosis" RELATED []
synonym: "caspase-independent cell death" NARROW []
synonym: "non-apoptotic programmed cell death" NARROW []
synonym: "nonapoptotic programmed cell death" NARROW []
synonym: "PCD" RELATED []
synonym: "RCD" RELATED []
synonym: "regulated cell death" BROAD []
xref: Wikipedia:Programmed_cell_death
is_a: GO:0008219 ! cell death

[Term]
id: GO:0012502
name: induction of programmed cell death
namespace: biological_process
alt_id: GO:0012503
def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr]
synonym: "induction of non-apoptotic programmed cell death" NARROW []
synonym: "induction of nonapoptotic programmed cell death" NARROW []
is_a: GO:0043068 ! positive regulation of programmed cell death

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_candida
subset: goslim_flybase_ribbon
subset: goslim_yeast
xref: Wikipedia:Endomembrane_system
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0012506
name: vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]
xref: NIF_Subcellular:sao1153182838
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0031982 ! vesicle

[Term]
id: GO:0012507
name: ER to Golgi transport vesicle membrane
namespace: cellular_component
alt_id: GO:0030664
def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII coated vesicle membrane" EXACT []
synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT []
synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT []
synonym: "ER to Golgi constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "ER-Golgi transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030134 ! COPII-coated ER to Golgi transport vesicle

[Term]
id: GO:0012508
name: Golgi to ER transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai]
synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT []
synonym: "Golgi to ER constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT []
synonym: "Golgi-ER transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030663 ! COPI-coated vesicle membrane
relationship: part_of GO:0030142 ! COPI-coated Golgi to ER transport vesicle

[Term]
id: GO:0012509
name: inter-Golgi transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai]
synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030663 ! COPI-coated vesicle membrane
relationship: part_of GO:0030143 ! COPI-coated inter-Golgi transport vesicle

[Term]
id: GO:0012510
name: trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai]
synonym: "TGN transport vesicle membrane" EXACT []
synonym: "trans-Golgi network constitutive secretory pathway transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0012511
name: monolayer-surrounded lipid storage body
namespace: cellular_component
alt_id: GO:0009520
def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372]
synonym: "oil body" EXACT []
synonym: "oilbody" EXACT []
synonym: "oleosome" EXACT []
synonym: "spherosome" EXACT []
xref: Wikipedia:Oil_body
is_a: GO:0005811 ! lipid droplet

[Term]
id: GO:0014000
name: morula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the morula over time. The morula is a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745]
is_a: GO:0009790 ! embryo development

[Term]
id: GO:0014001
name: sclerenchyma cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jid, PO:0000077]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0014002
name: astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef]
synonym: "astrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0014003
name: oligodendrocyte development
namespace: biological_process
def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef]
synonym: "oligodendrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0014004
name: microglia differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef]
synonym: "microglial cell differentiation" EXACT []
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0030225 ! macrophage differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0014005
name: microglia development
namespace: biological_process
def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef]
synonym: "microglial cell development" EXACT []
is_a: GO:0021782 ! glial cell development
is_a: GO:0061515 ! myeloid cell development
relationship: part_of GO:0014004 ! microglia differentiation

[Term]
id: GO:0014006
name: regulation of microglia differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "regulation of microglial cell differentiation" EXACT []
is_a: GO:0045649 ! regulation of macrophage differentiation
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014007
name: negative regulation of microglia differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "down regulation of microglia differentiation" EXACT []
synonym: "down-regulation of microglia differentiation" EXACT []
synonym: "downregulation of microglia differentiation" EXACT []
synonym: "inhibition of microglia differentiation" NARROW []
synonym: "negative regulation of microglial cell differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045650 ! negative regulation of macrophage differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
relationship: negatively_regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014008
name: positive regulation of microglia differentiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "activation of microglia differentiation" NARROW []
synonym: "positive regulation of microglial cell differentiation" EXACT []
synonym: "stimulation of microglia differentiation" NARROW []
synonym: "up regulation of microglia differentiation" EXACT []
synonym: "up-regulation of microglia differentiation" EXACT []
synonym: "upregulation of microglia differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045651 ! positive regulation of macrophage differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
relationship: positively_regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014009
name: glial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585]
synonym: "glia proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0014010
name: Schwann cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585]
is_a: GO:0014009 ! glial cell proliferation

[Term]
id: GO:0014011
name: Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585]
is_a: GO:0014010 ! Schwann cell proliferation
relationship: part_of GO:0014012 ! peripheral nervous system axon regeneration

[Term]
id: GO:0014012
name: peripheral nervous system axon regeneration
namespace: biological_process
def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef]
synonym: "axon regeneration in peripheral nervous system" EXACT []
is_a: GO:0031103 ! axon regeneration

[Term]
id: GO:0014013
name: regulation of gliogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
is_a: GO:0050767 ! regulation of neurogenesis
relationship: regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014014
name: negative regulation of gliogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "down regulation of gliogenesis" EXACT []
synonym: "down-regulation of gliogenesis" EXACT []
synonym: "downregulation of gliogenesis" EXACT []
synonym: "inhibition of gliogenesis" NARROW []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
relationship: negatively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014015
name: positive regulation of gliogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "activation of gliogenesis" NARROW []
synonym: "stimulation of gliogenesis" NARROW []
synonym: "up regulation of gliogenesis" EXACT []
synonym: "up-regulation of gliogenesis" EXACT []
synonym: "upregulation of gliogenesis" EXACT []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
relationship: positively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014016
name: neuroblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0014017
name: neuroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0014016 ! neuroblast differentiation

[Term]
id: GO:0014018
name: neuroblast fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0014017 ! neuroblast fate commitment

[Term]
id: GO:0014019
name: neuroblast development
namespace: biological_process
def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0014016 ! neuroblast differentiation

[Term]
id: GO:0014020
name: primary neural tube formation
namespace: biological_process
alt_id: GO:0014024
def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585, PMID:15327780]
synonym: "neural rod cavitation" RELATED []
synonym: "primary neural tube morphogenesis" EXACT [GOC:dph]
synonym: "primary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0014021
name: secondary neural tube formation
namespace: biological_process
alt_id: GO:0014026
alt_id: GO:0014027
def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585, PMID:15327780]
synonym: "medullary cord biosynthesis" EXACT []
synonym: "medullary cord formation" EXACT []
synonym: "medullary rod cavitation" RELATED []
synonym: "neural rod formation" RELATED []
synonym: "secondary neural tube rod cavitation" RELATED []
synonym: "secondary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0014022
name: neural plate elongation
namespace: biological_process
def: "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0014023
name: neural rod formation
namespace: biological_process
def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0014025
name: neural keel formation
namespace: biological_process
def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0014023 ! neural rod formation

[Term]
id: GO:0014028
name: notochord formation
namespace: biological_process
def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0048570 ! notochord morphogenesis

[Term]
id: GO:0014029
name: neural crest formation
namespace: biological_process
def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:dh, GOC:ef]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0014030
name: mesenchymal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014031
name: mesenchymal cell development
namespace: biological_process
def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014032
name: neural crest cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048864 ! stem cell development
relationship: part_of GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:0014033
name: neural crest cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0048863 ! stem cell differentiation

[Term]
id: GO:0014034
name: neural crest cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0048865 ! stem cell fate commitment
relationship: part_of GO:0014029 ! neural crest formation
relationship: part_of GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:0014035
name: neural crest cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef]
is_a: GO:0048867 ! stem cell fate determination
relationship: part_of GO:0014034 ! neural crest cell fate commitment

[Term]
id: GO:0014036
name: neural crest cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef]
is_a: GO:0048866 ! stem cell fate specification
relationship: part_of GO:0014034 ! neural crest cell fate commitment

[Term]
id: GO:0014037
name: Schwann cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0014038
name: regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014039
name: negative regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "down regulation of Schwann cell differentiation" EXACT []
synonym: "down-regulation of Schwann cell differentiation" EXACT []
synonym: "downregulation of Schwann cell differentiation" EXACT []
synonym: "inhibition of Schwann cell differentiation" NARROW []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014040
name: positive regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "activation of Schwann cell differentiation" NARROW []
synonym: "stimulation of Schwann cell differentiation" NARROW []
synonym: "up regulation of Schwann cell differentiation" EXACT []
synonym: "up-regulation of Schwann cell differentiation" EXACT []
synonym: "upregulation of Schwann cell differentiation" EXACT []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
relationship: positively_regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014041
name: regulation of neuron maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:1903429 ! regulation of cell maturation
relationship: regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014042
name: positive regulation of neuron maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "activation of neuron maturation" NARROW []
synonym: "stimulation of neuron maturation" NARROW []
synonym: "up regulation of neuron maturation" EXACT []
synonym: "up-regulation of neuron maturation" EXACT []
synonym: "upregulation of neuron maturation" EXACT []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:1903431 ! positive regulation of cell maturation
relationship: positively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014043
name: negative regulation of neuron maturation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "down regulation of neuron maturation" EXACT []
synonym: "down-regulation of neuron maturation" EXACT []
synonym: "downregulation of neuron maturation" EXACT []
synonym: "inhibition of neuron maturation" NARROW []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:1903430 ! negative regulation of cell maturation
relationship: negatively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014044
name: Schwann cell development
namespace: biological_process
def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef]
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014045
name: establishment of endothelial blood-brain barrier
namespace: biological_process
def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:aruk, GOC:dgh, GOC:dph, GOC:sart, PMID:20080302, PMID:30280653]
synonym: "establishment of endothelial BBB" EXACT []
synonym: "establishment of endothelial blood/brain barrier" EXACT []
is_a: GO:0060856 ! establishment of blood-brain barrier
is_a: GO:0061028 ! establishment of endothelial barrier

[Term]
id: GO:0014046
name: dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef]
is_a: GO:0015872 ! dopamine transport
is_a: GO:0023061 ! signal release
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0014047
name: glutamate secretion
namespace: biological_process
def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0014048
name: regulation of glutamate secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014049
name: positive regulation of glutamate secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "activation of glutamate secretion" NARROW []
synonym: "stimulation of glutamate secretion" NARROW []
synonym: "up regulation of glutamate secretion" EXACT []
synonym: "up-regulation of glutamate secretion" EXACT []
synonym: "upregulation of glutamate secretion" EXACT []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014050
name: negative regulation of glutamate secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "down regulation of glutamate secretion" EXACT []
synonym: "down-regulation of glutamate secretion" EXACT []
synonym: "downregulation of glutamate secretion" EXACT []
synonym: "inhibition of glutamate secretion" NARROW []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014051
name: gamma-aminobutyric acid secretion
namespace: biological_process
def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef]
synonym: "GABA secretion" EXACT []
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0014052
name: regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "regulation of GABA secretion" EXACT []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014053
name: negative regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW []
synonym: "negative regulation of GABA secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014054
name: positive regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "activation of gamma-aminobutyric acid secretion" NARROW []
synonym: "positive regulation of GABA secretion" EXACT []
synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW []
synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051957 ! positive regulation of amino acid transport
relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014055
name: acetylcholine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061526 ! acetylcholine secretion
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0014056
name: regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014057
name: positive regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "activation of acetylcholine secretion" NARROW []
synonym: "stimulation of acetylcholine secretion" NARROW []
synonym: "up regulation of acetylcholine secretion" EXACT []
synonym: "up-regulation of acetylcholine secretion" EXACT []
synonym: "upregulation of acetylcholine secretion" EXACT []
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014058
name: negative regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "down regulation of acetylcholine secretion" EXACT []
synonym: "down-regulation of acetylcholine secretion" EXACT []
synonym: "downregulation of acetylcholine secretion" EXACT []
synonym: "inhibition of acetylcholine secretion" NARROW []
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014059
name: regulation of dopamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]
is_a: GO:0050433 ! regulation of catecholamine secretion
relationship: regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0014060
name: regulation of epinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef]
synonym: "regulation of adrenaline secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
relationship: regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0014061
name: regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef]
synonym: "regulation of noradrenaline secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
relationship: regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0014062
name: regulation of serotonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014063
name: negative regulation of serotonin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "down regulation of serotonin secretion" EXACT []
synonym: "down-regulation of serotonin secretion" EXACT []
synonym: "downregulation of serotonin secretion" EXACT []
synonym: "inhibition of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014064
name: positive regulation of serotonin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "activation of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
synonym: "stimulation of serotonin secretion" NARROW []
synonym: "up regulation of serotonin secretion" EXACT []
synonym: "up-regulation of serotonin secretion" EXACT []
synonym: "upregulation of serotonin secretion" EXACT []
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014065
name: obsolete phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "OBSOLETE. A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K]
comment: This term was obsoleted because it represents the same signal transduction cassette as phosphatidylinositol 3-kinase signaling/protein kinase B signal transductiong ; GO:0043491.
synonym: "phosphatidylinositol 3-kinase cascade" RELATED [GOC:signaling]
synonym: "phosphatidylinositol 3-kinase signal transduction" EXACT [GOC:signaling]
synonym: "phosphoinositide 3-kinase cascade" EXACT []
synonym: "PI 3-kinase cascade" EXACT []
synonym: "PI3K cascade" EXACT []
synonym: "PI3K signal transduction" EXACT [GOC:signaling]
synonym: "PI3K signaling" EXACT [GOC:signaling]
is_obsolete: true
replaced_by: GO:0043491

[Term]
id: GO:0014066
name: obsolete regulation of phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
comment: This term was obsoleted because it represents the same signal transduction cassette as regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction ; GO:0051896.
synonym: "regulation of phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "regulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "regulation of PI 3-kinase cascade" RELATED []
synonym: "regulation of PI3K cascade" EXACT []
is_obsolete: true
replaced_by: GO:0051896

[Term]
id: GO:0014067
name: obsolete negative regulation of phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
comment: This term was obsoleted because it represents the same signal transduction cassette as negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction ; GO:0051898.
synonym: "down regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "down-regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "downregulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "inhibition of phosphatidylinositol 3-kinase cascade" NARROW []
synonym: "negative regulation of phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "negative regulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "negative regulation of PI 3-kinase cascade" EXACT []
synonym: "negative regulation of PI3K cascade" EXACT []
is_obsolete: true
replaced_by: GO:0051898

[Term]
id: GO:0014068
name: obsolete positive regulation of phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
comment: This term was obsoleted because it represents the same signal transduction cassette as positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction ; GO:0051897.
synonym: "activation of phosphoinositide 3-kinase cascade" NARROW []
synonym: "positive regulation of phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "positive regulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "positive regulation of PI 3-kinase cascade" EXACT []
synonym: "positive regulation of PI3K cascade" EXACT []
synonym: "stimulation of phosphatidylinositol 3-kinase cascade" NARROW []
synonym: "up regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "up-regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "upregulation of phosphatidylinositol 3-kinase cascade" EXACT []
is_obsolete: true
replaced_by: GO:0051897

[Term]
id: GO:0014069
name: postsynaptic density
namespace: cellular_component
alt_id: GO:0097481
alt_id: GO:0097483
def: "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density]
subset: goslim_synapse
synonym: "neuronal postsynaptic density" EXACT [GO:0097481]
synonym: "post synaptic density" EXACT []
synonym: "post-synaptic density" EXACT []
synonym: "postsynaptic density of dendrite" NARROW []
xref: NIF_Subcellular:sao1196688972
xref: Wikipedia:Postsynaptic_density
is_a: GO:0099572 ! postsynaptic specialization
relationship: part_of GO:0032279 ! asymmetric synapse

[Term]
id: GO:0014070
name: response to organic cyclic compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:ef]
synonym: "response to organic cyclic substance" EXACT [GOC:mah]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0014071
name: response to cycloalkane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:ef]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0014072
name: response to isoquinoline alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:ef]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0014073
name: response to tropane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:ef]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0014074
name: response to purine-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:ef]
synonym: "response to purine" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0014075
name: response to amine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef]
synonym: "response to amine stimulus" EXACT [GOC:dos]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0014076
name: response to fluoxetine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:ef, GOC:pr]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to selective serotonin reuptake inhibitor" RELATED []
synonym: "response to SSRI" RELATED []
is_a: GO:0036276 ! response to antidepressant

[Term]
id: GO:0014701
name: junctional sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle]
is_a: GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:0014702
name: free sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle]
is_a: GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:0014703
name: oscillatory muscle contraction
namespace: biological_process
def: "A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014704
name: intercalated disc
namespace: cellular_component
def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910]
synonym: "intercalated disk" EXACT []
xref: Wikipedia:Intercalated_disc
is_a: GO:0044291 ! cell-cell contact zone

[Term]
id: GO:0014705
name: C zone
namespace: cellular_component
def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0014706
name: striated muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle]
is_a: GO:0060537 ! muscle tissue development

[Term]
id: GO:0014707
name: branchiomeric skeletal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle]
is_a: GO:0007517 ! muscle organ development
is_a: GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014708
name: regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle]
is_a: GO:0048634 ! regulation of muscle organ development
relationship: regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014709
name: positive regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014708 ! regulation of somitomeric trunk muscle development
is_a: GO:0048636 ! positive regulation of muscle organ development
relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014710
name: negative regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014708 ! regulation of somitomeric trunk muscle development
is_a: GO:0048635 ! negative regulation of muscle organ development
relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014711
name: regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014712
name: positive regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014713
name: negative regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014714
name: myoblast fate commitment in head
namespace: biological_process
def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0014715
name: myoblast fate commitment in trunk
namespace: biological_process
def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0014716
name: skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration
namespace: biological_process
def: "Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt." [GOC:mtg_muscle]
comment: Occurrence of this process outside of the context of muscle repair is probably very rare, so there is a good case for merging this with the parent class.
synonym: "satellite cell asymmetric division involved in skeletal muscle regeneration" EXACT []
is_a: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division
relationship: part_of GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

[Term]
id: GO:0014717
name: regulation of satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle]
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014718
name: positive regulation of satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle]
is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration
is_a: GO:0043415 ! positive regulation of skeletal muscle tissue regeneration
is_a: GO:0050867 ! positive regulation of cell activation
relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014719
name: skeletal muscle satellite cell activation
namespace: biological_process
def: "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle, PMID:23303905]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0014720
name: tonic skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014721
name: twitch skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014722
name: regulation of skeletal muscle contraction by calcium ion signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT []
is_a: GO:0014819 ! regulation of skeletal muscle contraction
is_a: GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0014723
name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle]
synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT []
is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling

[Term]
id: GO:0014724
name: regulation of twitch skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction
relationship: regulates GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0014725
name: regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014726
name: negative regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014725 ! regulation of extraocular skeletal muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014727
name: positive regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014725 ! regulation of extraocular skeletal muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014728
name: regulation of the force of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle]
is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion

[Term]
id: GO:0014729
name: regulation of the velocity of shortening of skeletal muscle modulating contraction
namespace: biological_process
def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle]
synonym: "regulation of the velocity of shortening of skeletal muscle during contraction" RELATED [GOC:dph]
is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0014730
name: skeletal muscle regeneration at neuromuscular junction
namespace: biological_process
def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers." [GOC:mtg_muscle]
is_a: GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014731
name: spectrin-associated cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0014732
name: skeletal muscle atrophy
namespace: biological_process
def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014891 ! striated muscle atrophy
is_a: GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014733
name: regulation of skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014734
name: skeletal muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014897 ! striated muscle hypertrophy
is_a: GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014735
name: regulation of muscle atrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014736
name: negative regulation of muscle atrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0014735 ! regulation of muscle atrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
relationship: negatively_regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014737
name: positive regulation of muscle atrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0014735 ! regulation of muscle atrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
relationship: positively_regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014738
name: regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014739
name: positive regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0014744 ! positive regulation of muscle adaptation
relationship: positively_regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014740
name: negative regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0014745 ! negative regulation of muscle adaptation
relationship: negatively_regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014741
name: negative regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014742
name: positive regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014743
name: regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0090257 ! regulation of muscle system process
relationship: regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014744
name: positive regulation of muscle adaptation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "positive regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014745
name: negative regulation of muscle adaptation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "negative regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014746
name: regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction
relationship: regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014747
name: positive regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014748
name: negative regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014801
name: longitudinal sarcoplasmic reticulum
namespace: cellular_component
def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0014802
name: terminal cisterna
namespace: cellular_component
def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle]
xref: Wikipedia:Terminal_cisterna
is_a: GO:0098827 ! endoplasmic reticulum subcompartment
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0014803
name: longitudinal sarcoplasmic reticulum lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae." [GOC:mtg_muscle]
is_a: GO:0033018 ! sarcoplasmic reticulum lumen
relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum

[Term]
id: GO:0014804
name: terminal cisterna lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle]
is_a: GO:0033018 ! sarcoplasmic reticulum lumen
relationship: part_of GO:0014802 ! terminal cisterna

[Term]
id: GO:0014805
name: smooth muscle adaptation
namespace: biological_process
def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "smooth muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014806
name: smooth muscle hyperplasia
namespace: biological_process
def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014807
name: regulation of somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001756 ! somitogenesis

[Term]
id: GO:0014808
name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
namespace: biological_process
def: "The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle]
synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb]
is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport
is_a: GO:1903514 ! release of sequestered calcium ion into cytosol by endoplasmic reticulum

[Term]
id: GO:0014809
name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling

[Term]
id: GO:0014810
name: positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
is_a: GO:0045989 ! positive regulation of striated muscle contraction

[Term]
id: GO:0014811
name: negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
is_a: GO:0045988 ! negative regulation of striated muscle contraction

[Term]
id: GO:0014812
name: muscle cell migration
namespace: biological_process
def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0014813
name: skeletal muscle satellite cell commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0014816 ! skeletal muscle satellite cell differentiation

[Term]
id: GO:0014814
name: axon regeneration at neuromuscular junction
namespace: biological_process
def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0031103 ! axon regeneration

[Term]
id: GO:0014815
name: obsolete initiation of skeletal muscle satellite cell activation by growth factor signaling, involved in skeletal muscle regeneration
namespace: biological_process
def: "OBSOLETE. Signaling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
comment: The reason for obsoletion is that the term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0014816
name: skeletal muscle satellite cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0035914 ! skeletal muscle cell differentiation

[Term]
id: GO:0014817
name: skeletal muscle satellite cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment

[Term]
id: GO:0014818
name: skeletal muscle satellite cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048867 ! stem cell fate determination
relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment

[Term]
id: GO:0014819
name: regulation of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0006942 ! regulation of striated muscle contraction
relationship: regulates GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0014820
name: tonic smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014821
name: phasic smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014822
name: detection of wounding
namespace: biological_process
def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle]
synonym: "detection of injury" EXACT []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0014823
name: response to activity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle]
synonym: "response to exercise" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0014824
name: artery smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MSH:D001158]
is_a: GO:0014820 ! tonic smooth muscle contraction
is_a: GO:0014829 ! vascular associated smooth muscle contraction

[Term]
id: GO:0014825
name: stomach fundus smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, MA:0001612]
is_a: GO:0014847 ! proximal stomach smooth muscle contraction

[Term]
id: GO:0014826
name: vein smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MSH:D014680]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014829 ! vascular associated smooth muscle contraction

[Term]
id: GO:0014827
name: intestine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014828
name: distal stomach smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, PMID:30252381]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0120063 ! stomach smooth muscle contraction

[Term]
id: GO:0014829
name: vascular associated smooth muscle contraction
namespace: biological_process
def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718]
synonym: "vascular smooth muscle contraction" EXACT []
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0042310 ! vasoconstriction

[Term]
id: GO:0014830
name: arteriole smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MSH:D001160]
is_a: GO:0014824 ! artery smooth muscle contraction

[Term]
id: GO:0014831
name: gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014832
name: urinary bladder smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mr, GOC:mtg_muscle, PMID:11768524, PMID:18276178, PMID:538956]
is_a: GO:0014848 ! urinary tract smooth muscle contraction

[Term]
id: GO:0014833
name: skeletal muscle satellite stem cell asymmetric division
namespace: biological_process
def: "The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
synonym: "satellite cell asymmetric division" EXACT []
is_a: GO:0048103 ! somatic stem cell division
is_a: GO:0098722 ! asymmetric stem cell division
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014834
name: skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905]
synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb]
synonym: "satellite cell population maintenance" EXACT []
synonym: "satellite cell self-renewal" BROAD []
is_a: GO:0098727 ! maintenance of cell number
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014835
name: myoblast differentiation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0045445 ! myoblast differentiation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014836
name: myoblast fate commitment involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048625 ! myoblast fate commitment
relationship: part_of GO:0014835 ! myoblast differentiation involved in skeletal muscle regeneration

[Term]
id: GO:0014837
name: myoblast fate determination involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0007518 ! myoblast fate determination
relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration

[Term]
id: GO:0014838
name: myoblast fate specification involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048626 ! myoblast fate specification
relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration

[Term]
id: GO:0014839
name: myoblast migration involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD []
is_a: GO:0051451 ! myoblast migration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014841
name: skeletal muscle satellite cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014842
name: regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
relationship: regulates GO:0014841 ! skeletal muscle satellite cell proliferation

[Term]
id: GO:0014843
name: growth factor dependent regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation

[Term]
id: GO:0014844
name: myoblast proliferation involved in skeletal muscle regeneration
namespace: biological_process
def: "The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0051450 ! myoblast proliferation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014845
name: stomach body smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, MA:0002559]
is_a: GO:0014828 ! distal stomach smooth muscle contraction

[Term]
id: GO:0014846
name: esophagus smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MSH:D041742]
synonym: "oesophagus smooth muscle contraction" RELATED [GOC:dph]
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014847
name: proximal stomach smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, PMID:30252381]
is_a: GO:0014820 ! tonic smooth muscle contraction
is_a: GO:0120063 ! stomach smooth muscle contraction

[Term]
id: GO:0014848
name: urinary tract smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014849
name: ureter smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014848 ! urinary tract smooth muscle contraction

[Term]
id: GO:0014850
name: response to muscle activity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle]
is_a: GO:0014823 ! response to activity

[Term]
id: GO:0014852
name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014853
name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
namespace: biological_process
def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle]
synonym: "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction" EXACT []
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
relationship: part_of GO:0003009 ! skeletal muscle contraction
relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014854
name: response to inactivity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle]
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0014855
name: striated muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle]
is_a: GO:0033002 ! muscle cell proliferation

[Term]
id: GO:0014856
name: skeletal muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0014855 ! striated muscle cell proliferation

[Term]
id: GO:0014857
name: regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014858
name: positive regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014859
name: negative regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014860
name: neurotransmitter secretion involved in regulation of skeletal muscle contraction
namespace: biological_process
def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb]
synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007269 ! neurotransmitter secretion
relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014861
name: regulation of skeletal muscle contraction via regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED []
is_a: GO:0014819 ! regulation of skeletal muscle contraction
is_a: GO:0098900 ! regulation of action potential
relationship: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential

[Term]
id: GO:0014862
name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014863
name: detection of inactivity
namespace: biological_process
def: "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014854 ! response to inactivity
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0014864
name: detection of muscle activity
namespace: biological_process
def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014850 ! response to muscle activity
is_a: GO:0014865 ! detection of activity

[Term]
id: GO:0014865
name: detection of activity
namespace: biological_process
def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014823 ! response to activity
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0014866
name: skeletal myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0030239 ! myofibril assembly

[Term]
id: GO:0014868
name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction

[Term]
id: GO:0014869
name: detection of muscle inactivity
namespace: biological_process
def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014863 ! detection of inactivity
is_a: GO:0014870 ! response to muscle inactivity

[Term]
id: GO:0014870
name: response to muscle inactivity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle]
is_a: GO:0014854 ! response to inactivity

[Term]
id: GO:0014871
name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction

[Term]
id: GO:0014872
name: myoblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0014873
name: response to muscle activity involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to fatigue" EXACT []
synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014850 ! response to muscle activity
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation

[Term]
id: GO:0014874
name: response to stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0050896 ! response to stimulus
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014875
name: detection of muscle activity involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "detection of fatigue" EXACT []
is_a: GO:0014864 ! detection of muscle activity
is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation

[Term]
id: GO:0014876
name: response to injury involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to injury involved in regulation of muscle plasticity" RELATED []
is_a: GO:0009611 ! response to wounding
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation

[Term]
id: GO:0014877
name: response to muscle inactivity involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014870 ! response to muscle inactivity
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation

[Term]
id: GO:0014878
name: response to electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
is_a: GO:0051602 ! response to electrical stimulus

[Term]
id: GO:0014879
name: detection of electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation
is_a: GO:0050981 ! detection of electrical stimulus

[Term]
id: GO:0014880
name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb]
is_a: GO:0032971 ! regulation of muscle filament sliding
relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle modulating contraction

[Term]
id: GO:0014881
name: regulation of myofibril size
namespace: biological_process
def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]
synonym: "change of myofibril size" EXACT []
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0014882
name: regulation of myofibril number
namespace: biological_process
def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]
synonym: "change of myofibril number" EXACT []
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0014883
name: transition between fast and slow fiber
namespace: biological_process
def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle]
synonym: "transition between fast and slow fibre" EXACT []
synonym: "transition fast-slow fiber" EXACT []
synonym: "transition fast-slow fibre" EXACT []
is_a: GO:0014733 ! regulation of skeletal muscle adaptation

[Term]
id: GO:0014884
name: detection of muscle inactivity involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014869 ! detection of muscle inactivity
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014885
name: detection of injury involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "detection of injury involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014822 ! detection of wounding
is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation

[Term]
id: GO:0014886
name: transition between slow and fast fiber
namespace: biological_process
def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle]
synonym: "transition between slow and fast fibre" EXACT []
synonym: "transition slow-fast fiber" EXACT []
synonym: "transition slow-fast fibre" EXACT []
is_a: GO:0014733 ! regulation of skeletal muscle adaptation

[Term]
id: GO:0014887
name: cardiac muscle adaptation
namespace: biological_process
def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle]
synonym: "cardiac muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation

[Term]
id: GO:0014888
name: striated muscle adaptation
namespace: biological_process
def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "striated muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014889
name: muscle atrophy
namespace: biological_process
def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
comment: GO:0014889 should only be used for annotation when muscle atrophy is a normal physiological process and not a disease process.
xref: Wikipedia:Muscle_atrophy
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014890
name: smooth muscle atrophy
namespace: biological_process
def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014889 ! muscle atrophy

[Term]
id: GO:0014891
name: striated muscle atrophy
namespace: biological_process
def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014888 ! striated muscle adaptation
is_a: GO:0014889 ! muscle atrophy

[Term]
id: GO:0014893
name: response to rest involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle]
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014894
name: response to denervation involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle]
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014895
name: smooth muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014896
name: muscle hypertrophy
namespace: biological_process
def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
xref: Wikipedia:Muscle_hypertrophy
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0014897
name: striated muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014898
name: cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
is_a: GO:0003299 ! muscle hypertrophy in response to stress
is_a: GO:0003300 ! cardiac muscle hypertrophy
is_a: GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0014899
name: cardiac muscle atrophy
namespace: biological_process
def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle]
is_a: GO:0014887 ! cardiac muscle adaptation
is_a: GO:0014891 ! striated muscle atrophy

[Term]
id: GO:0014900
name: muscle hyperplasia
namespace: biological_process
def: "A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle]
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014901
name: satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle]
is_a: GO:0014719 ! skeletal muscle satellite cell activation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014902
name: myotube differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0014904
name: myotube cell development
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0055002 ! striated muscle cell development
relationship: part_of GO:0014902 ! myotube differentiation

[Term]
id: GO:0014905
name: myoblast fusion involved in skeletal muscle regeneration
namespace: biological_process
def: "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0007520 ! myoblast fusion
relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration

[Term]
id: GO:0014906
name: myotube cell development involved in skeletal muscle regeneration
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0014904 ! myotube cell development
relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration

[Term]
id: GO:0014908
name: myotube differentiation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0014902 ! myotube differentiation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014909
name: smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration

[Term]
id: GO:0014910
name: regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014911
name: positive regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014912
name: negative regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014914
name: myoblast maturation involved in muscle regeneration
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048628 ! myoblast maturation

[Term]
id: GO:0014915
name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction
is_a: GO:0032972 ! regulation of muscle filament sliding speed

[Term]
id: GO:0014916
name: regulation of lung blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
synonym: "regulation of pulmonary blood pressure" EXACT []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0014917
name: obsolete positive regulation of diuresis by pressure natriuresis
namespace: biological_process
def: "OBSOLETE. The process in which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of diuresis by pressure natriuresis" EXACT []
is_obsolete: true
replaced_by: GO:0035818

[Term]
id: GO:0014918
name: obsolete positive regulation of natriuresis by pressure natriuresis
namespace: biological_process
def: "OBSOLETE. The process in which pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of natriuresis by pressure natriuresis" EXACT []
is_obsolete: true
replaced_by: GO:0035819

[Term]
id: GO:0015000
name: obsolete polyferredoxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "polyferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015001
name: obsolete high-potential iron-sulfur carrier
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "high-potential iron-sulfur carrier" EXACT []
synonym: "high-potential iron-sulphur carrier" EXACT []
synonym: "HiPIP" RELATED []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015002
name: obsolete heme-copper terminal oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd]
comment: This term was obsoleted because it groups the last enzymes in the electron transport chain, and is not an appropriate grouping term for molecular function.
synonym: "haem-copper terminal oxidase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015003
name: obsolete copper electron carrier
namespace: molecular_function
def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "copper electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015004
name: obsolete small blue copper electron carrier
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "small blue copper electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015005
name: obsolete azurin
namespace: molecular_function
def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "azurin" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0015006
name: obsolete plastocyanin
namespace: molecular_function
def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "plastocyanin" EXACT []
is_obsolete: true
replaced_by: GO:0046028

[Term]
id: GO:0015007
name: obsolete electron carrier, chlorophyll electron transport system
namespace: molecular_function
def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732]
comment: This term was made obsolete because it contains both process and function information.
synonym: "chlorophyll electron carrier" RELATED []
synonym: "electron carrier, chlorophyll electron transport system" EXACT []
is_obsolete: true
consider: GO:0009055
consider: GO:0009767

[Term]
id: GO:0015009
name: corrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732]
synonym: "corrin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:0015010
name: tetrahydrocorphin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [Wikipedia:Morphine]
synonym: "tetrahydrocorphin metabolism" EXACT []
is_a: GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process

[Term]
id: GO:0015011
name: nickel-tetrapyrrole coenzyme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, Wikipedia:Cofactor_F430]
synonym: "coenzyme F430 metabolic process" NARROW []
synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:0015012
name: heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]
synonym: "heparan sulfate proteoglycan anabolism" EXACT []
synonym: "heparan sulfate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulfate proteoglycan formation" EXACT []
synonym: "heparan sulfate proteoglycan synthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT []
synonym: "heparin proteoglycan biosynthetic process" RELATED []
xref: MetaCyc:PWY-6558
xref: RESID:AA0210
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0015013
name: obsolete heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide
namespace: biological_process
def: "OBSOLETE. The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194]
comment: This term was obsoleted because it represents a molecular function.
synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT []
synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT []
synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED []
is_obsolete: true

[Term]
id: GO:0015014
name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai]
synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "heparan sulfate proteoglycan chain elongation" EXACT []
synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED []
is_a: GO:0000271 ! polysaccharide biosynthetic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015015
name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification
namespace: biological_process
def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194]
synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT []
synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT []
synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED []
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015016
name: heparan sulfate N-sulfotransferase activity
namespace: molecular_function
alt_id: GO:0004393
alt_id: GO:0015022
alt_id: GO:0051910
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H+ + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)." [EC:2.8.2.8, RHEA:21980]
comment: Note that this activity includes EC:2.8.2.12 (deleted from EC).
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT []
synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT []
synonym: "desulfoheparin sulfotransferase activity" EXACT []
synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "heparan sulfate 2-N-sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED []
synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED []
synonym: "heparin N-sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT []
synonym: "heparitin N-sulfotransferase activity" EXACT []
synonym: "heparitin N-sulphotransferase activity" EXACT []
synonym: "heparitin sulfotransferase activity" EXACT []
synonym: "N-desulfoheparin sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "N-heparan sulfate sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "N-HSST activity" RELATED [EC:2.8.2.8]
synonym: "PAPS:DSH sulfotransferase activity" RELATED [EC:2.8.2.8]
synonym: "PAPS:N-desulfoheparin sulfotransferase activity" RELATED [EC:2.8.2.8]
xref: EC:2.8.2.8
xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-2022860 "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)"
xref: RHEA:21980
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0015017
name: obsolete glypican
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan').
synonym: "glypican" EXACT []
is_obsolete: true

[Term]
id: GO:0015018
name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H+ + UDP." [EC:2.4.1.135]
synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135]
synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" RELATED [EC:2.4.1.135]
synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" RELATED [EC:2.4.1.135]
synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" RELATED [EC:2.4.1.135]
xref: EC:2.4.1.135
xref: MetaCyc:2.4.1.135-RXN
xref: Reactome:R-HSA-1889955 "B3GAT dimers transfer GlcA to tetrasaccharide linker"
xref: Reactome:R-HSA-3560802 "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker"
xref: Reactome:R-HSA-9638064 "B3GAT3 dimer transfers GlcA to tetrasaccharide linker"
xref: RHEA:24168
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0015019
name: heparan-alpha-glucosaminide N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosaminyl-[heparan sulfate](n) + acetyl-CoA = N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) + CoA + H+." [RHEA:15125]
synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" RELATED [EC:2.3.1.78]
synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" RELATED [EC:2.3.1.78]
synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED []
xref: EC:2.3.1.78
xref: MetaCyc:2.3.1.78-RXN
xref: Reactome:R-HSA-1678660 "HGSNAT oligomer acetylates Heparan sulfate chain(3)"
xref: Reactome:R-HSA-2090085 "HGSNAT oligomer acetylates Heparan chain(1)"
xref: Reactome:R-HSA-2263492 "Defective HGSNAT does not acetylate Heparan chain(1)"
xref: Reactome:R-HSA-9036056 "Defective HGSNAT does not acetylate Heparan sulfate chain(3)"
xref: RHEA:15125
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0015020
name: glucuronosyltransferase activity
namespace: molecular_function
alt_id: GO:0003981
def: "Catalysis of the reaction: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H+ + UDP." [RHEA:21032]
synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "GT activity" RELATED [EC:2.4.1.17]
synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17]
synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronic acid transferase activity" RELATED [EC:2.4.1.17]
synonym: "UDP glucuronosyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "UDP glucuronyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" RELATED [EC:2.4.1.17]
synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP-glucuronosyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "UDP-glucuronyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "UDPGA transferase activity" RELATED [EC:2.4.1.17]
synonym: "UDPGA-glucuronyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [EC:2.4.1.17]
synonym: "UDPGT activity" RELATED [EC:2.4.1.17]
synonym: "uridine 5'-diphosphoglucuronyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "uridine diphosphate glucuronyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronosyltransferase activity" RELATED [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronyltransferase activity" RELATED [EC:2.4.1.17]
xref: EC:2.4.1.17
xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-158546 "UGTs glucuronate APAP to APAP-GlcA"
xref: Reactome:R-HSA-159179 "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG"
xref: Reactome:R-HSA-159194 "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG"
xref: Reactome:R-HSA-174916 "Formation of N-glucuronides"
xref: Reactome:R-HSA-174931 "UGTs transfer GlcA from UDP-GlcA to O-centre substrates"
xref: Reactome:R-HSA-2162099 "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP"
xref: Reactome:R-HSA-5604954 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL"
xref: Reactome:R-HSA-5604975 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL"
xref: Reactome:R-HSA-5617143 "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA"
xref: Reactome:R-HSA-8941701 "UGT1A10 transfers GlcA from UDP-GlcA to GCTN"
xref: Reactome:R-HSA-9036102 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG"
xref: Reactome:R-HSA-9036104 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG"
xref: Reactome:R-HSA-9632038 "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG"
xref: Reactome:R-HSA-9632039 "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG"
xref: Reactome:R-HSA-9638097 "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA"
xref: Reactome:R-HSA-9749977 "UGT1A6 glucuronates ST"
xref: Reactome:R-HSA-9756134 "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL"
xref: Reactome:R-HSA-9756156 "UGT1A3 lactonizes ATV to ATVL"
xref: Reactome:R-HSA-9756183 "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL"
xref: Reactome:R-HSA-9758661 "UGT2B7,2B17,1A3 glucuronidates PRED metabolites"
xref: RHEA:21032
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0015021
name: heparin-sulfate lyase activity
namespace: molecular_function
def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8]
synonym: "[heparan sulfate]-sulfate lyase activity" RELATED []
synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8]
synonym: "heparin-sulphate lyase activity" EXACT []
synonym: "heparitin-sulfate lyase activity" EXACT []
synonym: "heparitinase I" RELATED [EC:4.2.2.8]
synonym: "heparitinase II" RELATED [EC:4.2.2.8]
xref: EC:4.2.2.8
xref: MetaCyc:4.2.2.8-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0015023
name: obsolete syndecan
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "syndecan" EXACT []
is_obsolete: true

[Term]
id: GO:0015024
name: glucuronate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18]
synonym: "chondro-2-sulfatase activity" RELATED [EC:3.1.6.18]
synonym: "glucuronate-2-sulphatase activity" EXACT []
synonym: "glucurono-2-sulfatase activity" RELATED [EC:3.1.6.18]
synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" RELATED [EC:3.1.6.18]
xref: EC:3.1.6.18
xref: MetaCyc:3.1.6.18-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0015025
name: obsolete GPI-anchored membrane-bound receptor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "GPI-anchored membrane-bound receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0015026
name: coreceptor activity
namespace: molecular_function
alt_id: GO:0015027
alt_id: GO:0015028
def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]
synonym: "coreceptor, insoluble ligand activity" RELATED [GOC:mah]
synonym: "coreceptor, soluble ligand activity" RELATED [GOC:mah]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0015029
name: obsolete internalization receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind.
synonym: "internalization receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015030
name: Cajal body
namespace: cellular_component
def: "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]
synonym: "coiled body" EXACT []
synonym: "Gemini of coiled bodies" RELATED []
synonym: "Gems" RELATED []
xref: NIF_Subcellular:nlx_subcell_090901
xref: Wikipedia:Cajal_body
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0015031
name: protein transport
namespace: biological_process
alt_id: GO:0015831
def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_chembl
subset: goslim_pir
subset: goslim_yeast
synonym: "enzyme transport" NARROW []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015032
name: obsolete storage protein import into fat body
namespace: biological_process
def: "OBSOLETE. The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using 'receptor-mediated endocytosis'.
synonym: "fat body metabolic process" BROAD []
synonym: "fat body metabolism" BROAD []
synonym: "fat body storage protein uptake" EXACT []
synonym: "import of storage protein into fat body" EXACT []
synonym: "storage protein import by fat body cells" EXACT []
synonym: "storage protein import into fat body cells" EXACT []
synonym: "storage protein transport into fat body cells" EXACT []
synonym: "storage protein uptake into fat body cells" EXACT []
is_obsolete: true

[Term]
id: GO:0015034
name: obsolete cytochrome P450 activity
namespace: molecular_function
def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423]
comment: This term was made obsolete because it is a grouping term representing a set of gene products.
synonym: "cytochrome P450 activity" EXACT []
is_obsolete: true
consider: GO:0019825

[Term]
id: GO:0015035
name: protein-disulfide reductase activity
namespace: molecular_function
alt_id: GO:0008895
alt_id: GO:0015037
def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]
synonym: "haem lyase disulphide oxidoreductase activity" NARROW []
synonym: "heme lyase disulfide oxidoreductase activity" NARROW []
synonym: "peptide disulfide oxidoreductase activity" EXACT []
synonym: "peptide disulphide oxidoreductase activity" EXACT []
synonym: "protein disulfide oxidoreductase activity" EXACT []
synonym: "protein disulfide-oxidoreductase activity" EXACT []
synonym: "protein disulphide oxidoreductase activity" EXACT []
xref: MetaCyc:DISULFOXRED-RXN
xref: Reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds"
xref: Reactome:R-HSA-264997 "P4HB mediates disulfide bond formation in Proinsulin"
xref: Reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1"
xref: Reactome:R-HSA-9817575 "ERO1B oxidizes P4HB"
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0015036
name: disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators]
synonym: "disulphide oxidoreductase activity" EXACT []
xref: Reactome:R-HSA-1222417 "TrxA reactivates AhpC"
xref: Reactome:R-HSA-1222644 "TrxA/B1 reactivates Tpx"
xref: Reactome:R-HSA-1222655 "AhpD reactivates AhpC"
xref: Reactome:R-HSA-1222690 "DlaT reactivates AhpD"
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0015038
name: glutathione disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah]
synonym: "glutaredoxin" BROAD []
synonym: "glutathione disulphide oxidoreductase activity" EXACT []
synonym: "glutathione oxidoreductase activity" BROAD []
xref: Reactome:R-HSA-111746 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)"
is_a: GO:0015036 ! disulfide oxidoreductase activity

[Term]
id: GO:0015039
name: NADPH-adrenodoxin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [GOC:kd, RHEA:42312]
comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'.
synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2]
synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd]
synonym: "NADPH:adrenodoxin oxidoreductase activity" RELATED [EC:1.18.1.2]
xref: EC:1.18.1.6
xref: MetaCyc:RXN-13685
xref: RHEA:42312
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0015040
name: obsolete electron transfer flavoprotein, group I
namespace: molecular_function
def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "electron transfer flavoprotein, group I" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015041
name: obsolete electron transfer flavoprotein, group II
namespace: molecular_function
def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "electron transfer flavoprotein, group II" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015042
name: trypanothione-disulfide reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [RHEA:16757]
synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12]
synonym: "trypanothione reductase activity" BROAD []
synonym: "trypanothione-disulfide reductase (NADP) activity" EXACT []
synonym: "trypanothione-disulfide reductase activity" BROAD []
synonym: "trypanothione-disulphide reductase activity" BROAD []
synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12]
xref: EC:1.8.1.12
xref: MetaCyc:1.8.1.12-RXN
xref: RHEA:16757
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0015043
name: leghemoglobin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6]
synonym: "ferric leghemoglobin reductase activity" RELATED [EC:1.6.2.6]
synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" RELATED [EC:1.6.2.6]
xref: EC:1.6.2.6
xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0015044
name: rubredoxin-NAD+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [RHEA:18597]
synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" RELATED [EC:1.18.1.1]
synonym: "DPNH-rubredoxin reductase activity" RELATED [EC:1.18.1.1]
synonym: "NADH--rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.1]
synonym: "NADH--rubredoxin reductase activity" RELATED [EC:1.18.1.1]
synonym: "NADH:rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.1]
synonym: "NADH:rubredoxin reductase activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" RELATED [EC:1.18.1.1]
synonym: "rubredoxin--NAD reductase activity" RELATED [EC:1.18.1.1]
synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" RELATED [EC:1.18.1.1]
synonym: "rubredoxin:NAD+ oxidoreductase activity" RELATED [EC:1.18.1.1]
xref: EC:1.18.1.1
xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN
xref: RHEA:18597
is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity

[Term]
id: GO:0015045
name: rubredoxin-NAD(P)+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4]
synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4]
synonym: "NAD(P)--rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.4]
synonym: "NAD(P)H--rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.4]
synonym: "NADPH:rubredoxin reductase activity" EXACT []
synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4]
synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" RELATED [EC:1.18.1.4]
synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" RELATED [EC:1.18.1.4]
xref: EC:1.18.1.4
xref: MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0015046
name: rubredoxin-NADP+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [RHEA:13949]
xref: RHEA:13949
is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity

[Term]
id: GO:0015047
name: NADPH-cytochrome-c2 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5]
synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" RELATED [EC:1.6.2.5]
synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" RELATED [EC:1.6.2.5]
synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.6.2.5]
xref: EC:1.6.2.5
xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN
xref: RHEA:15237
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0015048
name: phthalate dioxygenase reductase activity
namespace: molecular_function
def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0015049
name: methane monooxygenase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25, PMID:10896210]
synonym: "methane hydroxylase activity" RELATED [EC:1.14.13.25]
synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.13.25]
xref: EC:1.14.13.25
xref: MetaCyc:METHANE-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:r0237
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0015050
name: methane monooxygenase complex
namespace: cellular_component
def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [GOC:mah, PMID:15544]
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0015051
name: obsolete X-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors." [InterPro:IPR001420]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "X-opioid receptor activity" EXACT []
is_obsolete: true
consider: GO:0001626

[Term]
id: GO:0015052
name: beta3-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta3 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0015053
name: obsolete opsin
namespace: molecular_function
def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "opsin" EXACT []
is_obsolete: true
consider: GO:0007602
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015054
name: gastrin receptor activity
namespace: molecular_function
def: "Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity." [GOC:ai, GOC:signaling]
synonym: "cholecystokinin-B receptor activity" RELATED []
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0015055
name: secretin receptor activity
namespace: molecular_function
def: "Combining with secretin to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0015056
name: corticotrophin-releasing factor receptor activity
namespace: molecular_function
def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0015057
name: thrombin-activated receptor activity
namespace: molecular_function
alt_id: GO:0010655
def: "A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it." [GOC:ai, GOC:pg, PMID:20423334]
synonym: "thrombin receptor activity" EXACT []
synonym: "thrombin receptor activity, G-protein coupled" EXACT []
is_a: GO:0001648 ! proteinase-activated receptor activity

[Term]
id: GO:0015058
name: obsolete epidermal growth factor-like module containing hormone receptor activity
namespace: molecular_function
alt_id: GO:0016523
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "EGF-like module containing hormone receptor activity" EXACT []
synonym: "Egr1 hormone receptor" EXACT []
synonym: "epidermal growth factor-like module containing hormone receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015059
name: obsolete blue-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "blue-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015060
name: obsolete green-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "green-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015061
name: obsolete red-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "red-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009585
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015062
name: obsolete violet-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "violet-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015063
name: obsolete long-wave-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "long-wave-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015064
name: obsolete UV-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "UV-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007604
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015066
name: alpha-amylase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of alpha-amylase." [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0015067
name: amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai]
synonym: "transamidinase activity" EXACT []
xref: EC:2.1.4.-
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0015068
name: glycine amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [RHEA:13201]
synonym: "arginine-glycine amidinotransferase activity" RELATED [EC:2.1.4.1]
synonym: "arginine-glycine transamidinase activity" RELATED [EC:2.1.4.1]
synonym: "glycine transamidinase activity" RELATED [EC:2.1.4.1]
synonym: "L-arginine:glycine amidinotransferase activity" RELATED [EC:2.1.4.1]
xref: EC:2.1.4.1
xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN
xref: Reactome:R-HSA-71275 "arginine + glycine => ornithine + guanidoacetate"
xref: RHEA:13201
is_a: GO:0015067 ! amidinotransferase activity

[Term]
id: GO:0015069
name: scyllo-inosamine-4-phosphate amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine." [RHEA:13265]
synonym: "inosamine-P amidinotransferase activity" RELATED [EC:2.1.4.2]
synonym: "inosamine-phosphate amidinotransferase activity" EXACT []
synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" RELATED [EC:2.1.4.2]
synonym: "L-arginine:inosamine phosphate amidinotransferase activity" RELATED [EC:2.1.4.2]
synonym: "L-arginine:inosamine-P-amidinotransferase activity" RELATED [EC:2.1.4.2]
xref: EC:2.1.4.2
xref: KEGG_REACTION:R03477
xref: MetaCyc:2.1.4.2-RXN
xref: RHEA:13265
is_a: GO:0015067 ! amidinotransferase activity

[Term]
id: GO:0015070
name: obsolete toxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl]
comment: This term was made obsolete because it represents a classification of molecules and not a molecular function.
synonym: "toxin activity" EXACT []
is_obsolete: true
consider: GO:0090729

[Term]
id: GO:0015072
name: obsolete phosphatidylinositol 3-kinase, class I, catalyst activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" EXACT []
is_obsolete: true
consider: GO:0016303
consider: GO:0035005
consider: GO:0046934

[Term]
id: GO:0015073
name: obsolete phosphatidylinositol 3-kinase, class I, regulator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0046935

[Term]
id: GO:0015074
name: DNA integration
namespace: biological_process
def: "The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
subset: goslim_pir
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0015075
name: monoatomic ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
synonym: "ion transmembrane transporter activity" BROAD []
synonym: "ion transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015076
name: obsolete heavy metal ion transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal ion transporter activity" EXACT []
is_obsolete: true
consider: GO:0046873

[Term]
id: GO:0015078
name: proton transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]
synonym: "hydrogen ion transmembrane transporter activity" EXACT []
synonym: "proton transporter activity" EXACT []
xref: Reactome:R-HSA-1222516 "Intraphagosomal pH is lowered to 5 by V-ATPase"
xref: Reactome:R-HSA-164834 "Enzyme-bound ATP is released"
xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion"
xref: Reactome:R-HSA-170026 "UCP1 imports a proton"
xref: Reactome:R-HSA-74723 "Endosome acidification"
xref: Reactome:R-HSA-917841 "Acidification of Tf:TfR1 containing endosome"
xref: Reactome:R-HSA-9864415 "AAC1 imports a proton"
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0015079
name: potassium ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015388
alt_id: GO:0022817
def: "Enables the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai]
synonym: "potassium transporter activity" EXACT []
synonym: "potassium uptake permease activity" RELATED []
synonym: "potassium uptake transmembrane transporter activity" RELATED []
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015080
name: silver ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of silver (Ag+) ions from one side of a membrane to the other." [GOC:ai]
synonym: "silver transporter activity" EXACT []
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015081
name: sodium ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0022816
def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF]
synonym: "sodium transporter activity" EXACT []
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015083
name: aluminum ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015084
def: "Enables the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "aluminium ion transporter activity" EXACT []
synonym: "aluminium resistance permease activity" EXACT []
synonym: "aluminum resistance permease activity" EXACT []
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity

[Term]
id: GO:0015085
name: calcium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf]
xref: MetaCyc:TRANS-RXN-144
xref: Reactome:R-HSA-2534359 "CatSper Channel Mediated Calcium Transport"
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015086
name: cadmium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:dgf]
synonym: "zinc, cadmium uptake permease activity" RELATED []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015087
name: cobalt ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other." [GOC:dgf]
synonym: "cobalt, zinc uptake permease activity" RELATED []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
xref: MetaCyc:TRANS-RXN-141A
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015089
name: high-affinity copper ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:9.A.11.1.1]
synonym: "high affinity copper ion transmembrane transporter activity" EXACT []
synonym: "high affinity copper transporter activity" EXACT []
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0015090
name: low-affinity ferric iron ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:9.A.9.1.1]
synonym: "low affinity iron ion transmembrane transporter activity" EXACT []
synonym: "low affinity iron transporter activity" EXACT []
is_a: GO:0015091 ! ferric iron transmembrane transporter activity

[Term]
id: GO:0015091
name: ferric iron transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732]
comment: Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity.
is_a: GO:0005381 ! iron ion transmembrane transporter activity

[Term]
id: GO:0015092
name: high-affinity ferric iron transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:ai, PMID:1447137]
synonym: "high affinity ferric uptake transmembrane transporter activity" RELATED []
is_a: GO:0015091 ! ferric iron transmembrane transporter activity

[Term]
id: GO:0015093
name: ferrous iron transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015639
def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732]
synonym: "ferrous iron uptake transmembrane transporter activity" RELATED []
xref: MetaCyc:TRANS-RXN-8
xref: Reactome:R-HSA-1362417 "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix"
xref: Reactome:R-HSA-442368 "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region"
xref: Reactome:R-HSA-5655760 "Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol"
is_a: GO:0005381 ! iron ion transmembrane transporter activity

[Term]
id: GO:0015094
name: lead ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai]
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015095
name: magnesium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]
xref: MetaCyc:TRANS-RXN-141
xref: Reactome:R-HSA-442661 "SLC41A1,2 transport Mg2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5336453 "NIPAs transport Mg2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5336454 "MMGT1 transports Mg2+ from cytosol to Golgi lumen"
xref: Reactome:R-HSA-5336466 "MRS2 transports Mg2+ from cytosol to mitochondrial matrix"
xref: Reactome:R-HSA-5339528 "TUSC3 transports Mg2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5339538 "MAGT1 transports Mg2+ from extracellular region to cytosol"
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015096
name: obsolete manganese resistance permease activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport]
comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition.
synonym: "manganese resistance permease activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015097
name: mercury ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other." [GOC:ai]
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015098
name: molybdate ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732]
synonym: "molybdate transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015099
name: nickel cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nickel (Ni) cations from one side of a membrane to the other." [GOC:ai]
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
xref: MetaCyc:TRANS-RXN-141B
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015100
name: vanadium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai]
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015101
name: organic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]"
xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells"
xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney"
xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations"
xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells"
xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney"
xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations"
xref: Reactome:R-HSA-9794270 "SLCO1A2 transports Cipro(1+) into the cytosol"
xref: Reactome:R-HSA-9794523 "SLC22A1 transports Cipro into renal cell"
xref: Reactome:R-HSA-9795207 "SLC22A1 transports Cipro into hepatic cell"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015103
name: inorganic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai]
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity

[Term]
id: GO:0015104
name: antimonite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of antimonite from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015105
name: arsenite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arsenite from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015106
name: bicarbonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]
synonym: "hydrogencarbonate transmembrane transporter activity" EXACT []
xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region"
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0015107
name: chlorate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other." [GOC:curators]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015108
name: chloride transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008555
def: "Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai]
synonym: "ATP-dependent chloride transmembrane transporter activity" NARROW []
synonym: "ATPase-coupled chloride transmembrane transporter activity" NARROW []
synonym: "chloride ABC transporter" NARROW []
synonym: "chloride ion transmembrane transporter activity" EXACT [GOC:pr]
synonym: "chloride transporting ATPase activity" NARROW []
synonym: "chloride-transporting ATPase activity" NARROW []
xref: Reactome:R-HSA-5678822 "Defective CFTR does not transport Cl- from cytosol to extracellular region"
xref: Reactome:R-HSA-5678863 "CFTR transports Cl- from cytosol to extracellular region"
xref: Reactome:R-HSA-5678992 "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region"
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015109
name: chromate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015110
name: cyanate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015111
name: iodide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of iodide ions from one side of a membrane to the other." [GOC:ai]
xref: Reactome:R-HSA-209910 "Iodide is taken up by thyroid epithelial cells"
xref: Reactome:R-HSA-5627802 "SLC26A4 transports I- from cytosol to extracellular region"
xref: Reactome:R-HSA-5627870 "SLC26A4 does not transport I- from cytosol to extracellular region"
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015112
name: nitrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai]
synonym: "nitrite/nitrate porter activity" RELATED []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015113
name: nitrite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other." [GOC:ai]
synonym: "nitrite/nitrate porter activity" RELATED []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015114
name: obsolete phosphate ion transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of phosphate ions from one side of a membrane to the other." [GOC:ai]
comment: This term was obsoleted because it represents the same activity as phosphate transmembrane transporter activity ; GO:0005315 (phosphate ion == inorganic phosphate).
synonym: "phosphate transmembrane transporter activity" RELATED [GOC:vw]
is_obsolete: true
replaced_by: GO:0005315

[Term]
id: GO:0015115
name: silicate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015116
name: sulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]
synonym: "sulfate permease activity" RELATED []
synonym: "sulphate transporter activity" EXACT []
xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol"
xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015117
name: thiosulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of thiosulfate ions, HS2O3(1-), from one side of a membrane to the other." [GOC:ai]
synonym: "thiosulfate permease activity" RELATED []
synonym: "thiosulphate transporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-496
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015119
name: hexose phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015120
name: phosphoglycerate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai]
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0015121
name: phosphoenolpyruvate:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)." [GOC:bf, GOC:jl]
synonym: "phosphoenolpyruvate/phosphate translocator" EXACT []
synonym: "PPT" BROAD [PMID:10488230]
is_a: GO:0015315 ! organophosphate:phosphate antiporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity
is_a: GO:0089721 ! phosphoenolpyruvate transmembrane transporter activity

[Term]
id: GO:0015123
name: acetate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015124
name: allantoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684]
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015125
name: bile acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai]
xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol"
xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol"
xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A"
xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)"
xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)"
xref: Reactome:R-HSA-9733964 "SLC51A:SLC51B transports bile salts from cytosol to extracellular region"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015126
name: canalicular bile acid transmembrane transporter activity
namespace: molecular_function
def: "The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph]
is_a: GO:0015125 ! bile acid transmembrane transporter activity

[Term]
id: GO:0015127
name: bilirubin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684]
xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region"
xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region"
xref: Reactome:R-HSA-9661417 "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region"
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015128
name: gluconate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732]
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0015129
name: lactate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
xref: Reactome:R-HSA-373867 "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-373875 "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015130
name: mevalonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015131
name: oxaloacetate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity

[Term]
id: GO:0015132
name: prostaglandin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai]
synonym: "prostaglandin/thromboxane transporter activity" BROAD []
xref: Reactome:R-HSA-5661188 "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol"
xref: Reactome:R-HSA-879528 "SLCO2A1 transports PGT substrates from extracellular region to cytosol"
xref: Reactome:R-HSA-9032327 "5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region"
is_a: GO:0071714 ! icosanoid transmembrane transporter activity

[Term]
id: GO:0015133
name: uronic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0015134
name: hexuronate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015163
def: "Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "hexuronide transmembrane transporter activity" EXACT []
is_a: GO:0015133 ! uronic acid transmembrane transporter activity

[Term]
id: GO:0015135
name: glucuronate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015136
name: sialic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sialic acid from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015137
name: citrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other." [GOC:ai]
synonym: "tricarboxylate transport protein" RELATED [TC:2.A.29.7.2]
xref: Reactome:R-HSA-433104 "NACT co-transports trivalent citrate and a sodium ion"
xref: TC:2.A.29.7.2
is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015138
name: fumarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity

[Term]
id: GO:0015139
name: alpha-ketoglutarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684]
synonym: "2-oxoglutarate transporter activity" EXACT []
xref: Reactome:R-HSA-372480 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]"
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015140
name: malate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity

[Term]
id: GO:0015141
name: succinate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other." [ISBN:0198506732]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity

[Term]
id: GO:0015142
name: tricarboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai]
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:R-HSA-372449 "SLC25A1 may exchange mitochondrial PEP for cytosolic anion"
xref: Reactome:R-HSA-75849 "SLC25A1 exchanges CIT and MAL"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015143
name: urate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai]
synonym: "uric acid transmembrane transporter activity" EXACT []
xref: Reactome:R-HSA-2872497 "SLC17A3-2 transports cytosolic urate to extracellular region"
xref: Reactome:R-HSA-561253 "SLC22A12 exchanges extracellular urate for cytosolic LACT"
xref: Reactome:R-HSA-5625210 "Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT"
is_a: GO:1901702 ! salt transmembrane transporter activity

[Term]
id: GO:0015144
name: carbohydrate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901476
def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
synonym: "carbohydrate transporter activity" RELATED []
synonym: "sugar transporter" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015145
name: monosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0051119 ! sugar transmembrane transporter activity

[Term]
id: GO:0015146
name: pentose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0015147
name: L-arabinose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW []
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015148
name: D-xylose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0015146 ! pentose transmembrane transporter activity

[Term]
id: GO:0015149
name: hexose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region"
xref: Reactome:R-HSA-5638222 "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region"
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0015150
name: fucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015151
name: alpha-glucoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:28510148]
is_a: GO:0042947 ! glucoside transmembrane transporter activity

[Term]
id: GO:0015152
name: glucose-6-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity

[Term]
id: GO:0015153
name: rhamnose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0033297
def: "Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "ATP-dependent rhamnose transmembrane transporter activity" NARROW []
synonym: "ATPase-coupled rhamnose transmembrane transporter activity" NARROW []
synonym: "rhamnose-transporting ATPase activity" NARROW []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015154
name: disaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of disaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity

[Term]
id: GO:0015155
name: lactose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019189
def: "Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "lactose permease activity" EXACT []
synonym: "lactose/glucose efflux transporter activity" NARROW []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0015156
name: melibiose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0015157
name: oligosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oligosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
synonym: "endosomal oligosaccharide transporter" NARROW []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0015158
name: raffinose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "raffinose permease" RELATED []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity

[Term]
id: GO:0015159
name: polysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity

[Term]
id: GO:0015160
name: beta-glucan transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0015161
name: lipid III floppase activity
namespace: molecular_function
def: "Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, PMID:12621029, PMID:16816184]
synonym: "capsular polysaccharide transmembrane transporter activity" RELATED []
synonym: "capsule polysaccharide transporter activity" BROAD []
synonym: "undecaprenol-pyrophosphate O-antigen flippase activity" EXACT [TC:2.A.66.2.3]
xref: TC:2.A.66.2.12
xref: TC:2.A.66.2.3
is_a: GO:0140328 ! floppase activity

[Term]
id: GO:0015164
name: glucuronoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "glucuronide transporter activity" EXACT []
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015165
name: pyrimidine nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0015166
name: polyol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732]
synonym: "sugar/polyol channel activity" NARROW []
xref: Reactome:R-HSA-429571 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6"
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015167
name: arabitol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
synonym: "arabinitol transporter activity" EXACT []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015168
name: glycerol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015169
name: glycerol-3-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015170
name: propanediol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai]
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015171
name: amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015359
def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "amino acid permease activity" EXACT []
synonym: "amino acid transporter activity" BROAD []
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "general amino acid permease activity" RELATED []
synonym: "hydroxy/aromatic amino acid permease activity" RELATED []
xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes"
xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons"
xref: Reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol"
xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine"
xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine"
xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol"
xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake"
xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids"
xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids"
xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine"
xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids"
xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine"
xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine"
xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol"
xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine"
xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine"
xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine"
xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine"
xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane"
xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane"
xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine"
xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids"
xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate"
xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane"
xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine"
xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5659755 "Defective SLC6A18 does not transport Gly from extracellular region to cytosol"
xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol"
xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane"
xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen"
xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015172
name: acidic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "acidic amino acid transporter activity" BROAD []
xref: Reactome:R-HSA-372448 "SLC25A12,13 exchange L-Glu and L-Asp"
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015173
name: aromatic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "aromatic amino acid transporter activity" BROAD []
synonym: "hydroxy/aromatic amino acid permease activity" RELATED []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015174
name: basic amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005286
alt_id: GO:0015326
def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "basic amino acid permease activity" EXACT []
synonym: "basic amino acid transporter activity" BROAD []
synonym: "cationic amino acid transmembrane transporter activity" RELATED []
xref: Reactome:R-HSA-8932851 "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-8959781 "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix"
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015175
name: neutral L-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "neutral amino acid transmembrane transporter activity" EXACT []
synonym: "neutral amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015176
name: obsolete holin
namespace: molecular_function
def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "holin" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015179
name: L-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-amino acid transporter activity" BROAD []
xref: Reactome:R-HSA-212614 "Glutamine transport from astrocytes"
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015180
name: L-alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "L-alanine transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0022858 ! alanine transmembrane transporter activity

[Term]
id: GO:0015182
name: L-asparagine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "asparagine/glutamine permease activity" NARROW []
synonym: "L-asparagine transporter activity" BROAD []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0015183
name: L-aspartate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-aspartate transporter activity" BROAD []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity

[Term]
id: GO:0015184
name: L-cystine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "cystine/diaminopimelate porter activity" NARROW []
synonym: "L-cystine transporter activity" BROAD []
xref: Reactome:R-HSA-5340130 "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol"
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0015185
name: gamma-aminobutyric acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "4-aminobutanoate transporter activity" EXACT []
synonym: "4-aminobutyrate transporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "GABA transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015186
name: L-glutamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "asparagine/glutamine permease activity" NARROW []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015187
name: glycine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai]
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "glycine transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015188
name: L-isoleucine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "L-isoleucine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity

[Term]
id: GO:0015189
name: L-lysine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005293
def: "Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-lysine permease" RELATED []
synonym: "lysine permease activity" RELATED []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015190
name: L-leucine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-leucine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity

[Term]
id: GO:0015191
name: L-methionine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-methionine transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0043865 ! methionine transmembrane transporter activity

[Term]
id: GO:0015192
name: L-phenylalanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-phenylalanine permease activity" EXACT []
synonym: "L-phenylalanine transporter activity" BROAD []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015193
name: L-proline transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005296
def: "Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "L-proline permease activity" RELATED []
synonym: "L-proline transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
xref: Reactome:R-HSA-8870354 "SLC36A4 transports extracellular L-Pro to the cytosol"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015194
name: L-serine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015511
alt_id: GO:1905361
def: "Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport]
synonym: "L-serine permease activity" RELATED []
synonym: "L-serine transporter activity" BROAD []
synonym: "serine transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" RELATED []
xref: Reactome:R-HSA-8932980 "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015195
name: L-threonine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015512
def: "Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-threonine permease activity" RELATED []
synonym: "L-threonine transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" RELATED []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015196
name: L-tryptophan transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005299
def: "Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-tryptophan permease activity" EXACT []
synonym: "L-tryptophan transporter activity" BROAD []
synonym: "valine/tyrosine/tryptophan permease activity" NARROW []
xref: Reactome:R-HSA-8870352 "SLC36A4 transports L-Trp from extracellular region to cytosol"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015199
name: amino-acid betaine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid." [GOC:ai]
synonym: "betaine transmembrane transporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0015200
name: methylammonium transmembrane transporter activity
namespace: molecular_function
def: "Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity

[Term]
id: GO:0015203
name: polyamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other." [GOC:ai]
synonym: "amine/amide/polyamine channel activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015204
name: urea transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015287
def: "Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2." [ISBN:0198506732]
synonym: "urea transporter activity" BROAD []
xref: Reactome:R-HSA-444126 "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively"
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0015205
name: nucleobase transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015392
def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015207
name: adenine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators]
xref: Reactome:R-HSA-163215 "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane"
xref: Reactome:R-HSA-5672027 "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane"
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity

[Term]
id: GO:0015208
name: guanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators]
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity

[Term]
id: GO:0015209
name: cytosine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators]
is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity

[Term]
id: GO:0015210
name: uracil transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators]
synonym: "uracil/uridine permease activity" RELATED []
is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity

[Term]
id: GO:0015211
name: purine nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity

[Term]
id: GO:0015212
name: cytidine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators]
is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity

[Term]
id: GO:0015213
name: uridine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators]
synonym: "uracil/uridine permease activity" NARROW []
is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity

[Term]
id: GO:0015214
name: pyrimidine nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity

[Term]
id: GO:0015215
name: nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732]
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity

[Term]
id: GO:0015216
name: purine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0015217
name: ADP transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0015218
name: pyrimidine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0015219
name: obsolete protein-DNA complex transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of protein-DNA complexes from one side of a membrane to the other." [GOC:ai]
comment: This term was obsoleted because there is no experimental evidence that this function exists.
synonym: "DNA-protein complex transmembrane transporter activity" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0015220
name: choline transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005306
def: "Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "choline permease activity" EXACT []
xref: Reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol"
xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix"
is_a: GO:0015101 ! organic cation transmembrane transporter activity

[Term]
id: GO:0015221
name: lipopolysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "LPS transmembrane transporter activity" EXACT []
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015223
name: obsolete vitamin or cofactor transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "vitamin or cofactor transporter activity" EXACT []
synonym: "vitamin/cofactor transporter activity" EXACT []
is_obsolete: true
consider: GO:0090482

[Term]
id: GO:0015224
name: biopterin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732]
synonym: "biopterin transporter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015225
name: biotin transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901603
def: "Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai]
synonym: "biotin transporter activity" RELATED []
synonym: "vitamin B7 transporter activity" RELATED []
synonym: "vitamin H transporter activity" RELATED []
xref: MetaCyc:TRANS-RXN0-240
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015226
name: carnitine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai]
synonym: "vitamin Bt transporter activity" EXACT []
xref: Reactome:R-HSA-164967 "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space"
xref: Reactome:R-HSA-165026 "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol"
xref: Reactome:R-HSA-549297 "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5625674 "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol"
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0015227
name: acyl carnitine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai]
synonym: "acylcarnitine transporter activity" BROAD []
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity

[Term]
id: GO:0015228
name: coenzyme A transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
synonym: "coenzyme A transporter activity" BROAD []
xref: Reactome:R-HSA-199216 "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix"
xref: Reactome:R-HSA-9837333 "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015229
name: L-ascorbic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ISBN:0198506732]
synonym: "L-ascorbate transporter activity" EXACT []
synonym: "vitamin C transporter activity" EXACT []
xref: Reactome:R-HSA-198870 "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol"
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0015230
name: FAD transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005472
def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732]
synonym: "FAD carrier activity" RELATED []
synonym: "FAD transporter activity" BROAD []
synonym: "flavin adenine dinucleotide carrier activity" RELATED []
synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "flavin-adenine dinucleotide carrier activity" RELATED []
synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0015231
name: 5-formyltetrahydrofolate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other." [GOC:ai]
synonym: "5-formyltetrahydrofolate transporter activity" EXACT []
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0015232
name: heme transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of heme from one side of a membrane to the other." [PMID:29549126]
synonym: "haem transporter activity" EXACT []
synonym: "heme transporter activity" BROAD []
xref: Reactome:R-HSA-917870 "SLC46A1 transports hemes from extracellular region to cytosol"
xref: Reactome:R-HSA-917892 "FLVCR1-1 transports heme from cytosol to extracellular region"
xref: Reactome:R-HSA-9661408 "FLVCR1-2 transports heme from mitochondrial matrix to cytosol"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015233
name: pantothenate transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
synonym: "pantothenate transporter activity" BROAD [GOC:mah]
synonym: "vitamin B5 transmembrane transporter activity" EXACT []
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0015234
name: thiamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015402
alt_id: GO:0015403
def: "Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "thiamin permease activity" EXACT []
synonym: "thiamin transmembrane transporter activity" EXACT []
synonym: "thiamin uptake transporter activity" RELATED []
synonym: "thiamine permease activity" EXACT []
synonym: "thiamine uptake transmembrane transporter activity" RELATED []
synonym: "vitamin B1 transporter activity" EXACT []
xref: Reactome:R-HSA-199626 "SLC19A2/3 transport extracellular THMN to cytosol"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015240
name: obsolete amiloride transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of amiloride from one side of a membrane to the other. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732]
comment: The reason for obsoletion is that these terms are beyond the scope of GO.
synonym: "amiloride transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0015243
name: cycloheximide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732]
synonym: "cycloheximide transporter activity" RELATED []
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0015244
name: fluconazole transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators]
synonym: "fluconazole transporter activity" RELATED []
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:0015245
name: fatty acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015246
def: "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]
synonym: "fatty acid transporter activity" RELATED []
synonym: "fatty acyl transporter activity" EXACT []
synonym: "fatty-acyl group transporter activity" BROAD []
synonym: "peroxisomal fatty acyl transporter" NARROW []
xref: Reactome:R-HSA-5627891 "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol"
xref: Reactome:R-HSA-879585 "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol"
xref: Reactome:R-HSA-9032315 "oxo-DHAs translocate from cytosol to extracellular region"
xref: Reactome:R-HSA-9032323 "oxo-DPAn-3s translocate from cytosol to extracellular region"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:0015247
name: aminophospholipid flippase activity
namespace: molecular_function
def: "Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:pg]
synonym: "aminophospholipid transmembrane transporter activity" RELATED []
synonym: "aminophospholipid transporter activity" RELATED []
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0140327 ! flippase activity

[Term]
id: GO:0015248
name: obsolete sterol transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true
consider: GO:0030228
consider: GO:0034041
consider: GO:0120015

[Term]
id: GO:0015250
name: water channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of water through a transmembrane aqueous pore or channel." [GOC:mtg_transport, ISBN:0815340729]
synonym: "aquaporin" NARROW []
xref: MetaCyc:TRANS-RXN-145
xref: Reactome:R-HSA-432010 "Aquaporin-1 passively transports water into cell"
xref: Reactome:R-HSA-432054 "Aquaporin-1 passively transports water out of cell"
xref: Reactome:R-HSA-432065 "p-S256-Aquaporin-2 passively transports water into cell"
xref: Reactome:R-HSA-432067 "Aquaporin-4 passively transports water out of cell"
xref: Reactome:R-HSA-445714 "Aquaporin-3 passively transports water out of cell"
xref: Reactome:R-HSA-507868 "Aquaporins passively transport water into cells"
xref: Reactome:R-HSA-507870 "Aquaporins passively transport water out of cells"
is_a: GO:0005372 ! water transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015252
name: proton channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
synonym: "hydrogen ion channel activity" EXACT []
xref: Reactome:R-HSA-9729542 "OTOP1 transports H+ from the extracellular region to the cytosol"
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0015078 ! proton transmembrane transporter activity

[Term]
id: GO:0015253
name: obsolete sugar/polyol channel activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "sugar/polyol channel activity" EXACT []
is_obsolete: true
consider: GO:0015166
consider: GO:0051119

[Term]
id: GO:0015254
name: glycerol channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of glycerol through a transmembrane aqueous pore or channel." [GOC:mtg_transport, ISBN:0815340729]
xref: MetaCyc:TRANS-RXN-131
xref: Reactome:R-HSA-432049 "Aquaporin-9 passively transports glycerol into cell"
xref: Reactome:R-HSA-432074 "Aquaporin-7 passively transports glycerol out of cell"
xref: Reactome:R-HSA-507869 "Aquaporins passively transport glycerol into cells"
xref: Reactome:R-HSA-507871 "Aquaporins passively transport glycerol out of cells"
is_a: GO:0015168 ! glycerol transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015255
name: propanediol channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of propanediol through a transmembrane aqueous pore or channel." [GOC:mtg_transport]
is_a: GO:0015170 ! propanediol transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015256
name: obsolete monocarboxylate channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "monocarboxylate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015257
name: obsolete organic anion channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "organic anion channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015258
name: obsolete gluconate channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "gluconate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015259
name: obsolete glutamate channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "glutamate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015260
name: obsolete isethionate channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "isethionate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015261
name: obsolete lactate channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "lactate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015262
name: obsolete taurine channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "taurine channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015263
name: obsolete amine/amide/polyamine channel activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents three molecular functions.
synonym: "amine/amide/polyamine channel activity" EXACT []
is_obsolete: true
consider: GO:0005275
consider: GO:0015203
consider: GO:0042887

[Term]
id: GO:0015264
name: methylammonium channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of methylammonium through a transmembrane aqueous pore or channel. Methylammonium is CH3NH2." [GOC:mtg_transport, GOC:pr]
is_a: GO:0015200 ! methylammonium transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015265
name: urea channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of urea through a transmembrane aqueous pore or channel." [GOC:mtg_transport]
xref: Reactome:R-HSA-507873 "Aquaporins passively transport urea out of cells"
xref: Reactome:R-HSA-507875 "Aquaporins passively transport urea into cells"
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015267
name: channel activity
namespace: molecular_function
alt_id: GO:0015249
alt_id: GO:0015268
alt_id: GO:0022838
def: "Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]
synonym: "alpha-type channel activity" RELATED []
synonym: "channel-forming toxin activity" RELATED []
synonym: "channel/pore class transporter activity" EXACT []
synonym: "nonselective channel activity" EXACT []
synonym: "pore activity" BROAD []
synonym: "pore class transporter activity" RELATED []
synonym: "substrate-specific channel activity" RELATED []
xref: Reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol"
xref: Reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix"
xref: TC:1
is_a: GO:0022803 ! passive transmembrane transporter activity

[Term]
id: GO:0015269
name: calcium-activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:mtg_transport]
xref: Reactome:R-HSA-9663752 "KCNN2 transports K+ from the cytosol to the extracellular region"
xref: Reactome:R-HSA-9667809 "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region"
is_a: GO:0005227 ! calcium-activated cation channel activity
is_a: GO:0005267 ! potassium channel activity

[Term]
id: GO:0015271
name: outward rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0015272
name: ATP-activated inward rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah]
xref: Reactome:R-HSA-5683209 "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)"
is_a: GO:0005242 ! inward rectifier potassium channel activity

[Term]
id: GO:0015274
name: organellar voltage-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "organellar voltage gated chloride channel activity" EXACT []
synonym: "organellar voltage-dependent chloride channel activity" EXACT []
is_a: GO:0005247 ! voltage-gated chloride channel activity

[Term]
id: GO:0015275
name: stretch-activated, monoatomic cation-selective, calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport]
synonym: "stretch-activated, cation-selective, calcium channel activity" BROAD []
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0140135 ! mechanosensitive monoatomic cation channel activity

[Term]
id: GO:0015276
name: ligand-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart]
synonym: "ligand-gated ion channel activity" BROAD []
xref: Reactome:R-HSA-451310 "Activation of Edited Kainate receptors"
xref: Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors"
xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors"
xref: Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors"
xref: Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors"
is_a: GO:0005216 ! monoatomic ion channel activity
is_a: GO:0022834 ! ligand-gated channel activity

[Term]
id: GO:0015277
name: kainate selective glutamate receptor activity
namespace: molecular_function
def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
is_a: GO:0004970 ! glutamate-gated receptor activity
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0015280 ! ligand-gated sodium channel activity

[Term]
id: GO:0015278
name: intracellularly gated calcium channel activity
namespace: molecular_function
alt_id: GO:0005218
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]
synonym: "calcium-release channel activity" EXACT []
synonym: "intracellular ligand-gated calcium channel activity" RELATED []
xref: Reactome:R-HSA-9717215 "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol"
is_a: GO:0005217 ! intracellularly ligand-gated monoatomic ion channel activity
is_a: GO:0099604 ! ligand-gated calcium channel activity

[Term]
id: GO:0015279
name: store-operated calcium channel activity
namespace: molecular_function
def: "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]
xref: Reactome:R-HSA-434798 "CRAC translocates calcium from the extracellular region to the cytosol"
is_a: GO:0005262 ! calcium channel activity

[Term]
id: GO:0015280
name: ligand-gated sodium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]
synonym: "acid-sensing ion channel activity" NARROW [GOC:fj]
synonym: "amiloride-sensitive sodium channel activity" NARROW [GOC:fj]
synonym: "ASIC activity" NARROW [GOC:fj]
synonym: "epithelial sodium channel" NARROW [GOC:fj]
xref: Reactome:R-HSA-2672334 "SCNN channels transport extracellular Na+ to cytosol"
is_a: GO:0005272 ! sodium channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0015282
name: obsolete NADPH oxidase-associated cytochrome b558 hydrogen channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it describes a gene product rather than a function.
synonym: "NADPH oxidase-associated cytochrome b558 hydrogen channel activity" EXACT []
synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT []
is_obsolete: true

[Term]
id: GO:0015283
name: obsolete apoptogenic cytochrome c release channel activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it represents a gene product.
synonym: "apoptogenic cytochrome c release channel activity" EXACT []
synonym: "Bcl-2" NARROW []
is_obsolete: true

[Term]
id: GO:0015284
name: fructose uniporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13]
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0015288
name: porin activity
namespace: molecular_function
def: "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-]
synonym: "outer membrane exporter porin" NARROW []
synonym: "porin" EXACT []
xref: Wikipedia:Porin_(protein)
is_a: GO:0022829 ! wide pore channel activity

[Term]
id: GO:0015289
name: obsolete pore-forming toxin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "pore-forming toxin activity" EXACT []
is_obsolete: true
consider: GO:0005198
consider: GO:0046930
consider: GO:0046931
consider: GO:0090729

[Term]
id: GO:0015291
name: secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015290
alt_id: GO:0015353
alt_id: GO:0015404
alt_id: GO:0015570
def: "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]
synonym: "active transporter" BROAD []
synonym: "coupled carrier" EXACT []
synonym: "electrochemical potential-driven transporter activity" EXACT []
synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW []
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
synonym: "heavy metal ion porter activity" NARROW []
synonym: "ion-gradient-driven energizer activity" NARROW []
synonym: "multidrug endosomal transmembrane transporter activity" NARROW []
synonym: "nitrite/nitrate porter activity" NARROW []
synonym: "porter activity" EXACT []
synonym: "porters" EXACT []
synonym: "secondary carrier-type facilitators" EXACT []
xref: TC:2.A
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0015292
name: uniporter activity
namespace: molecular_function
def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
synonym: "facilitated diffusion carrier" EXACT []
synonym: "single-species transporter activity" EXACT []
synonym: "uniport" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015293
name: symporter activity
namespace: molecular_function
def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
synonym: "cotransporter activity" BROAD []
synonym: "porter activity" BROAD []
synonym: "symport" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015294
name: solute:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai]
synonym: "solute:cation symporter activity" BROAD []
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0015293 ! symporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0015295
name: solute:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai]
synonym: "heavy metal ion:hydrogen symporter activity" NARROW []
synonym: "high affinity metal ion uptake transporter activity" NARROW []
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
synonym: "low affinity metal ion uptake transporter activity" NARROW []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
synonym: "solute:hydrogen symporter activity" EXACT []
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity

[Term]
id: GO:0015296
name: monoatomic anion:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-]
synonym: "anion:cation symporter activity" BROAD []
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity

[Term]
id: GO:0015297
name: antiporter activity
namespace: molecular_function
alt_id: GO:0015300
alt_id: GO:0099516
def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
synonym: "antiport" RELATED []
synonym: "countertransporter activity" EXACT []
synonym: "exchange transporter activity" EXACT []
synonym: "exchanger" BROAD []
synonym: "ion antiporter activity" NARROW []
synonym: "porter" BROAD []
synonym: "solute:solute antiporter activity" EXACT []
synonym: "solute:solute exchange" RELATED []
xref: Reactome:R-HSA-2730692 "CLCN4/5/6 exchange Cl- for H+"
xref: Reactome:R-HSA-2730959 "CLCN7:OSTM1 exchanges Cl- for H+"
xref: Reactome:R-HSA-2731002 "CLCN3 exchanges Cl- for H+"
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015298
name: obsolete solute:monoatomic cation antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "solute:cation antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015299
name: obsolete solute:proton antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW []
synonym: "solute:hydrogen antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015301
name: obsolete anion:anion antiporter activity
namespace: molecular_function
alt_id: GO:0015380
alt_id: GO:0015384
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport]
comment: This term was obsoleted because it was too general for a grouping class.
synonym: "anion exchanger activity" EXACT []
synonym: "bicarbonate:chloride antiporter" NARROW []
is_obsolete: true

[Term]
id: GO:0015303
name: obsolete galactose, glucose uniporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "galactose, glucose uniporter activity" EXACT []
is_obsolete: true
consider: GO:0015304
consider: GO:0050782

[Term]
id: GO:0015304
name: D-glucose uniporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) = D-glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6]
synonym: "galactose, glucose uniporter activity" NARROW []
synonym: "glucose uniporter activity" EXACT []
is_a: GO:0008516 ! hexose uniporter activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0015305
name: obsolete lactose, galactose:proton symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "lactose, galactose:hydrogen symporter activity" EXACT []
synonym: "lactose, galactose:proton symporter activity" EXACT []
synonym: "lactose,galactose:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015517
consider: GO:0015528

[Term]
id: GO:0015306
name: sialate:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10]
synonym: "cation/sialate symporter activity" EXACT []
synonym: "cation:sialate symporter activity" EXACT []
synonym: "sialate transporter activity" BROAD []
synonym: "sialate/cation symporter activity" EXACT []
synonym: "sialate:cation symporter activity" BROAD []
is_a: GO:0015136 ! sialic acid transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015307
name: obsolete drug:proton antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-]
comment: This term was obsoleted because it is not possible to state that every case of transmembrane transport for a specific chemical constitutes a drug transport.
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
synonym: "drug:hydrogen antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015308
name: obsolete amiloride:proton antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1]
comment: The reason for obsoletion is that these terms are beyond the scope of GO.
synonym: "amiloride:hydrogen antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015309
name: cycloheximide:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2]
synonym: "cycloheximide:hydrogen antiporter activity" EXACT []
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015243 ! cycloheximide transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0015310
name: benomyl:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6]
synonym: "benomyl:hydrogen antiporter activity" EXACT []
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0015311
name: monoamine:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12]
synonym: "monoamine:hydrogen antiporter activity" EXACT []
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0015312
name: polyamine:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16]
synonym: "polyamine:hydrogen antiporter activity" EXACT []
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015203 ! polyamine transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0015313
name: fluconazole:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17]
synonym: "fluconazole:hydrogen antiporter activity" EXACT []
is_a: GO:0015244 ! fluconazole transmembrane transporter activity
is_a: GO:0045119 ! azole:proton antiporter activity

[Term]
id: GO:0015314
name: aminotriazole:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1]
synonym: "aminotriazole:hydrogen antiporter activity" EXACT []
is_a: GO:0045119 ! azole:proton antiporter activity
is_a: GO:1901478 ! aminotriazole transmembrane transporter activity

[Term]
id: GO:0015315
name: organophosphate:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + phosphate(in) = organophosphate(in) +  phosphate(out)." [TC:2.A.1.4.-]
synonym: "organophosphate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0005315 ! phosphate transmembrane transporter activity
is_a: GO:0005452 ! solute:inorganic anion antiporter activity

[Term]
id: GO:0015316
name: obsolete nitrite/nitrate porter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "nitrite/nitrate porter activity" EXACT []
is_obsolete: true
consider: GO:0015112
consider: GO:0015113
consider: GO:0015291

[Term]
id: GO:0015317
name: phosphate:proton symporter activity
namespace: molecular_function
alt_id: GO:0015320
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-]
synonym: "phosphate ion carrier activity" EXACT []
synonym: "phosphate:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015318
name: inorganic molecular entity transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729]
subset: gocheck_do_not_annotate
synonym: "inorganic solute uptake transmembrane transporter activity" EXACT []
synonym: "inorganic uptake permease activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015319
name: obsolete sodium:inorganic phosphate symporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [TC:2.A.1.14.6]
comment: This term was obsoleted because it represents the same activity as sodium:phosphate symporter activity ; GO:0005436.
synonym: "sodium:phosphate symporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0005436

[Term]
id: GO:0015322
name: obsolete secondary active oligopeptide transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "oligopeptide porter activity" RELATED []
is_obsolete: true
consider: GO:0035673

[Term]
id: GO:0015323
name: obsolete type V protein secretor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type V protein secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015324
name: obsolete peptide-acetyl-CoA secondary active transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "peptide-acetyl-CoA transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0015325
name: acetyl-CoA:CoA antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1]
is_a: GO:0008521 ! acetyl-CoA transmembrane transporter activity
is_a: GO:0015228 ! coenzyme A transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0015327
name: cystine:glutamate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5]
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0015328
name: obsolete cystine secondary active transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "cystine porter activity" RELATED []
synonym: "cystinosin" NARROW []
synonym: "lysosomal cystine transporter" NARROW []
is_obsolete: true

[Term]
id: GO:0015330
name: high-affinity glutamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity glutamine permease activity" RELATED []
synonym: "high affinity glutamine transmembrane transporter activity" EXACT []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity

[Term]
id: GO:0015331
name: obsolete asparagine/glutamine permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "asparagine/glutamine permease activity" EXACT []
is_obsolete: true
consider: GO:0015182
consider: GO:0015186
consider: GO:0022857

[Term]
id: GO:0015332
name: obsolete leucine/valine/isoleucine permease activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "leucine/valine/isoleucine permease activity" EXACT []
is_obsolete: true
consider: GO:0005304
consider: GO:0015188
consider: GO:0015190
consider: GO:0022857

[Term]
id: GO:0015333
name: peptide:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-]
synonym: "peptide:hydrogen symporter activity" EXACT []
xref: Reactome:R-HSA-427998 "SLC25A1 transports di-/tri-peptides and peptide-like drugs"
xref: Reactome:R-HSA-428007 "Proton-coupled histidine and di-peptide cotransport"
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity

[Term]
id: GO:0015334
name: high-affinity oligopeptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport]
synonym: "high affinity oligopeptide transporter activity" EXACT []
synonym: "high-affinity oligopeptide transporter activity" RELATED []
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity

[Term]
id: GO:0015335
name: obsolete heavy metal ion:hydrogen symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "heavy metal ion:hydrogen symporter activity" EXACT []
synonym: "heavy metal ion:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015336
name: obsolete high affinity metal ion uptake transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "high affinity metal ion uptake transporter activity" EXACT []
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015337
name: obsolete low affinity metal ion uptake transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "low affinity metal ion uptake transporter activity" EXACT []
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015339
name: obsolete cobalt, zinc uptake permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "cobalt, zinc uptake permease activity" EXACT []
is_obsolete: true
consider: GO:0005385
consider: GO:0015087

[Term]
id: GO:0015340
name: obsolete zinc, cadmium uptake permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "zinc, cadmium uptake permease activity" EXACT []
is_obsolete: true
consider: GO:0005385
consider: GO:0015086

[Term]
id: GO:0015341
name: zinc efflux active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3]
synonym: "zinc efflux permease activity" BROAD []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity
is_a: GO:0022883 ! zinc efflux transmembrane transporter activity

[Term]
id: GO:0015342
name: obsolete zinc, iron permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "zinc, iron permease activity" EXACT []
is_obsolete: true
consider: GO:0005381
consider: GO:0005385

[Term]
id: GO:0015343
name: siderophore-iron transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015236
alt_id: GO:0015237
alt_id: GO:0042927
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [PMID:20376388, PMID:31748738]
synonym: "iron-siderophore transporter activity" EXACT []
synonym: "siderochrome transporter activity" NARROW []
synonym: "siderochrome-iron transporter activity" NARROW []
synonym: "siderophore transmembrane transporter activity" RELATED []
synonym: "siderophore transporter activity" RELATED []
synonym: "siderophore-iron transporter activity" RELATED []
xref: Reactome:R-HSA-1222597 "Loaded mycobactin gets imported"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015344
name: siderophore uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1]
synonym: "ferrioxamine uptake transmembrane transporter activity" RELATED []
synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW []
synonym: "siderophore-iron uptake transmembrane transporter activity" RELATED []
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity

[Term]
id: GO:0015345
name: ferric enterobactin:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2]
synonym: "ferric enterobactin:hydrogen symporter activity" EXACT []
synonym: "ferric-enterobactin:proton symporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015603 ! iron chelate transmembrane transporter activity

[Term]
id: GO:0015346
name: ferric triacetylfusarinine C:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3]
synonym: "ferric triacetylfusarinine C:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity
is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity

[Term]
id: GO:0015347
name: sodium-independent organic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators]
xref: Reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjugates"
xref: Reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity"
xref: Reactome:R-HSA-879584 "SLCO3A1 isoform 1 has abroad substrate specificity"
xref: Reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin"
xref: Reactome:R-HSA-9661397 "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
xref: Reactome:R-HSA-9661446 "BMG, BDG translocates from ER lumen to cytosol"
xref: Reactome:R-HSA-9661723 "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte)"
xref: Reactome:R-HSA-9661799 "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
xref: Reactome:R-HSA-9749583 "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes"
xref: Reactome:R-HSA-9749607 "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells"
xref: Reactome:R-HSA-9757010 "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015348
name: obsolete prostaglandin/thromboxane transporter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "prostaglandin/thromboxane transporter activity" EXACT []
is_obsolete: true
consider: GO:0008028
consider: GO:0015132

[Term]
id: GO:0015349
name: thyroid hormone transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai]
xref: Reactome:R-HSA-879575 "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol"
xref: Reactome:R-HSA-9631987 "SLCO1B1 transports T3,T4 from extracellular region to cytosol"
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015350
name: methotrexate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai]
synonym: "methotrexate transporter activity" RELATED []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0042910 ! xenobiotic transmembrane transporter activity

[Term]
id: GO:0015351
name: obsolete bilirubin secondary active transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "bilirubin porter activity" RELATED []
synonym: "bilitranslocase" NARROW []
is_obsolete: true

[Term]
id: GO:0015352
name: obsolete secondary active sterol transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of sterol from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport]
comment: This term was obsoleted because there is no evidence that this function exists.
synonym: "sterol porter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0015355
name: secondary active monocarboxylate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl]
synonym: "monocarboxylate porter activity" RELATED []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015356
name: obsolete monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" EXACT []
is_obsolete: true
consider: GO:0015129
consider: GO:0015130
consider: GO:0015562
consider: GO:0050833

[Term]
id: GO:0015358
name: obsolete amino acid/choline transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "amino acid/choline transmembrane transporter activity" EXACT []
is_obsolete: true
consider: GO:0015171
consider: GO:0015220

[Term]
id: GO:0015360
name: acetate:proton symporter activity
namespace: molecular_function
alt_id: GO:0015357
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1]
synonym: "acetate:hydrogen symporter activity" EXACT []
synonym: "hydrogen:acetate symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0043893 ! acetate:monoatomic cation symporter activity

[Term]
id: GO:0015361
name: low-affinity sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1]
synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD []
synonym: "low affinity sodium:dicarboxylate symporter activity" EXACT []
xref: Reactome:R-HSA-433131 "NaDC1 co-transports dicarboxylic acids and a sodium ion"
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity

[Term]
id: GO:0015362
name: high-affinity sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4]
synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD []
synonym: "high affinity sodium:dicarboxylate symporter activity" EXACT []
xref: Reactome:R-HSA-433101 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion"
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity

[Term]
id: GO:0015363
name: obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" EXACT []
is_obsolete: true
consider: GO:0005310
consider: GO:0015138
consider: GO:0015140
consider: GO:0015141
consider: GO:0015297

[Term]
id: GO:0015364
name: dicarboxylate:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + phosphate(in) = dicarboxylate(in) +  phosphate(out)." [TC:2.A.29.2.3]
synonym: "dicarboxylate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0005315 ! phosphate transmembrane transporter activity
is_a: GO:0005452 ! solute:inorganic anion antiporter activity

[Term]
id: GO:0015366
name: malate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1]
synonym: "L-malic acid permease" RELATED [GOC:vw]
synonym: "L-malic acid:proton symporter activity" RELATED [GOC:vw]
synonym: "malate permease" RELATED [GOC:vw]
synonym: "malate:hydrogen symporter activity" EXACT []
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015367
name: oxoglutarate:malate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1]
synonym: "2-oxoglutarate/malate carrier protein" EXACT [Wikipedia:Mitochondrial_carrier]
xref: Reactome:R-HSA-198440 "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane"
xref: Reactome:R-HSA-376851 "SLC25A11 exchanges 2-OG and MAL"
is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0015368
name: calcium:monoatomic cation antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-]
synonym: "calcium:cation antiporter activity" BROAD []
xref: Reactome:R-HSA-425822 "K+-independent Li+/Ca2+ exchanger transport"
is_a: GO:0015085 ! calcium ion transmembrane transporter activity
is_a: GO:0140828 ! metal cation:monoatomic cation antiporter activity

[Term]
id: GO:0015369
name: calcium:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [RHEA:71799, TC:2.A.19.2.-]
synonym: "calcium:hydrogen antiporter activity" EXACT []
xref: Reactome:R-HSA-8949687 "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)"
xref: RHEA:71799
is_a: GO:0015368 ! calcium:monoatomic cation antiporter activity
is_a: GO:0051139 ! metal cation:proton antiporter activity

[Term]
id: GO:0015370
name: solute:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai]
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
xref: Reactome:R-HSA-8876283 "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol"
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity

[Term]
id: GO:0015371
name: galactose:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-]
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015372
name: obsolete glutamate/aspartate:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "glutamate/aspartate:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005283
consider: GO:0005313
consider: GO:0015183

[Term]
id: GO:0015373
name: monoatomic anion:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in)." [TC:2.A.21.5.-]
synonym: "anion:sodium symporter activity" BROAD []
synonym: "monovalent anion:sodium symporter activity" RELATED []
is_a: GO:0015296 ! monoatomic anion:monoatomic cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015374
name: neutral, basic amino acid:sodium:chloride symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3]
synonym: "neutral, cationic amino acid:sodium:chloride symporter activity" RELATED []
is_a: GO:0005283 ! amino acid:sodium symporter activity

[Term]
id: GO:0015375
name: glycine:sodium symporter activity
namespace: molecular_function
alt_id: GO:0015656
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai]
xref: Reactome:R-HSA-444120 "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5660840 "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol"
xref: RHEA:68228
is_a: GO:0005295 ! neutral L-amino acid:sodium symporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015187 ! glycine transmembrane transporter activity

[Term]
id: GO:0015376
name: obsolete betaine/GABA:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "betaine/GABA:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005332
consider: GO:0015185
consider: GO:0015199
consider: GO:0015370

[Term]
id: GO:0015377
name: chloride:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [PMID:31747317]
synonym: "cation:chloride cotransporter activity" BROAD []
synonym: "cation:chloride symporter activity" BROAD []
xref: TC:2.A.30
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0015296 ! monoatomic anion:monoatomic cation symporter activity

[Term]
id: GO:0015378
name: sodium:chloride symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-]
xref: Reactome:R-HSA-426130 "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5623705 "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol"
is_a: GO:0015373 ! monoatomic anion:sodium symporter activity
is_a: GO:0015377 ! chloride:monoatomic cation symporter activity

[Term]
id: GO:0015379
name: potassium:chloride symporter activity
namespace: molecular_function
alt_id: GO:0022820
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.1.5]
synonym: "potassium ion symporter activity" BROAD []
xref: Reactome:R-HSA-426155 "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region"
xref: Reactome:R-HSA-5623806 "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region"
xref: RHEA:72427
xref: TC:2.A.30.1.5
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015377 ! chloride:monoatomic cation symporter activity

[Term]
id: GO:0015381
name: high-affinity sulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity sulfate permease activity" RELATED []
synonym: "high affinity sulfate transmembrane transporter activity" EXACT []
synonym: "high affinity sulphate permease activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity

[Term]
id: GO:0015382
name: sodium:sulfate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2]
synonym: "sodium:sulfate cotransporter activity" BROAD []
synonym: "sodium:sulphate symporter activity" EXACT []
xref: Reactome:R-HSA-433099 "NaS2 co-transports sulphate and two sodium ions"
xref: Reactome:R-HSA-433114 "NaS1 co-transports sulphate and a sodium ion"
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015383
name: sulfate:bicarbonate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2]
synonym: "sulfate:hydrogencarbonate antiporter activity" EXACT []
synonym: "sulphate:bicarbonate antiporter activity" EXACT []
is_a: GO:0005452 ! solute:inorganic anion antiporter activity
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity

[Term]
id: GO:0015385
name: sodium:proton antiporter activity
namespace: molecular_function
alt_id: GO:0015502
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]
synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW []
synonym: "pH-dependent sodium:proton antiporter activity" NARROW []
synonym: "sodium/hydrogen antiporter activity" EXACT []
synonym: "sodium:hydrogen antiporter activity" EXACT []
synonym: "sodium:hydrogen exchange activity" EXACT []
synonym: "sodium:hydrogen exchanger" EXACT []
xref: MetaCyc:TRANS-RXN-129
xref: Reactome:R-HSA-2872444 "SLC9B1/C2 exchange Na+ for H+"
xref: Reactome:R-HSA-2872463 "SLC9C1 exchanges Na+ for H+"
xref: Reactome:R-HSA-2889070 "SLC9B2 exchanges Na+ for H+"
xref: Reactome:R-HSA-425965 "SLC9A9 exchanges Na+ for H+ across the late endosome membrane"
xref: Reactome:R-HSA-425983 "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane"
xref: Reactome:R-HSA-425994 "Na+/H+ exchanger transport (at cell membrane)"
xref: Reactome:R-HSA-426015 "Na+/H+ exchanger transport (at trans-golgi membrane)"
xref: Reactome:R-HSA-5661039 "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane"
xref: Reactome:R-HSA-5661086 "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane"
xref: RHEA:29251
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0051139 ! metal cation:proton antiporter activity

[Term]
id: GO:0015386
name: potassium:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-]
synonym: "potassium:hydrogen antiporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-42
xref: RHEA:29467
is_a: GO:0022821 ! solute:potassium antiporter activity
is_a: GO:0051139 ! metal cation:proton antiporter activity

[Term]
id: GO:0015387
name: potassium:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-]
synonym: "potassium:hydrogen symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-3
xref: RHEA:28490
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015389
name: pyrimidine- and adenosine-specific:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in)." [TC:2.A.41.2.3]
synonym: "pyrimidine- and adenine-specific:sodium symporter activity" RELATED []
xref: TC:2.A.41.2.3
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity
is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity
is_a: GO:0005415 ! nucleoside:sodium symporter activity
is_a: GO:0015391 ! nucleobase:monoatomic cation symporter activity

[Term]
id: GO:0015390
name: purine-specific nucleoside:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1]
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015391
name: nucleobase:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai]
synonym: "nucleobase:cation symporter activity" BROAD []
is_a: GO:0015205 ! nucleobase transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity

[Term]
id: GO:0015393
name: obsolete uracil/uridine permease activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "uracil/uridine permease activity" EXACT []
is_obsolete: true
consider: GO:0015210
consider: GO:0015213
consider: GO:0022857

[Term]
id: GO:0015394
name: uridine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport]
synonym: "nucleoside (uridine) permease activity" RELATED []
synonym: "uridine:hydrogen ion symporter activity" EXACT []
is_a: GO:0015213 ! uridine transmembrane transporter activity
is_a: GO:0015506 ! nucleoside:proton symporter activity

[Term]
id: GO:0015395
name: nucleoside transmembrane transporter activity, down a concentration gradient
namespace: molecular_function
alt_id: GO:0015396
alt_id: GO:0015397
def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811]
synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity" NARROW []
synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity" NARROW []
synonym: "equilibrative nucleoside transporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity

[Term]
id: GO:0015398
name: obsolete high-affinity secondary active ammonium transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "high affinity secondary active ammonium transmembrane transporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0008519

[Term]
id: GO:0015399
name: primary active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy." [GOC:mtg_transport, PMID:31613498]
synonym: "primary active transporter" RELATED []
xref: EC:7.-.-.-
xref: TC:3
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0015400
name: obsolete low-affinity secondary active ammonium transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "low affinity ammonium transmembrane transporter activity" RELATED []
synonym: "low affinity secondary active ammonium transmembrane transporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015401
name: urea:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1]
synonym: "urea active transmembrane transporter activity" EXACT []
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015406
name: obsolete ABC-type uptake permease activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ABC-type uptake permease activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015407
name: ABC-type monosaccharide transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [MetaCyc:3.6.3.17-RXN]
synonym: "ATP-dependent monosaccharide transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled monosaccharide transmembrane transporter activity" RELATED []
synonym: "monosaccharide ABC transporter" NARROW []
synonym: "monosaccharide-importing ATPase activity" NARROW []
synonym: "monosaccharide-transporting ATPase activity" EXACT []
xref: MetaCyc:3.6.3.17-RXN
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0043211 ! ABC-type carbohydrate transporter activity

[Term]
id: GO:0015408
name: ABC-type ferric iron transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [RHEA:12332]
synonym: "ABC-type Fe3+ transporter" EXACT []
synonym: "ATPase-coupled ferric iron transmembrane transporter activity" RELATED []
synonym: "Fe3+-transporting ATPase activity" RELATED [EC:7.2.2.7]
synonym: "ferric ABC transporter" EXACT []
synonym: "ferric transporting ATPase activity" RELATED []
synonym: "ferric-transporting ATPase activity" RELATED []
xref: EC:7.2.2.7
xref: MetaCyc:3.6.3.30-RXN
xref: RHEA:12332
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015410
name: ABC-type manganese transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [RHEA:17365]
synonym: "ABC-type Mn(2+) transporter" RELATED [EC:7.2.2.5]
synonym: "ATP-dependent manganese transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled manganese transmembrane transporter activity" RELATED []
synonym: "manganese ABC transporter" NARROW []
synonym: "manganese transmembrane transporter activity, phosphorylative mechanism" RELATED []
synonym: "manganese-transporting ATPase activity" RELATED [EC:7.2.2.5]
xref: EC:7.2.2.5
xref: MetaCyc:3.6.3.35-RXN
xref: Reactome:R-HSA-5692462 "ATP13A1 transports Mn2+ from cytosol to ER lumen"
xref: RHEA:17365
is_a: GO:0005384 ! manganese ion transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015411
name: ABC-type taurine transporter transporter activity
namespace: molecular_function
def: "Enables the transfer of taurine from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [RHEA:14613]
synonym: "ATP-dependent taurine transporter activity" RELATED []
synonym: "ATPase-coupled taurine transporter activity" RELATED []
synonym: "taurine ABC transporter" EXACT [EC:7.6.2.7]
synonym: "taurine-transporting ATPase activity" RELATED [EC:7.6.2.7]
xref: EC:7.6.2.7
xref: MetaCyc:ABC-64-RXN
xref: RHEA:14613
is_a: GO:0005368 ! taurine transmembrane transporter activity
is_a: GO:0042959 ! ABC-type alkanesulfonate transporter transporter activity

[Term]
id: GO:0015412
name: ABC-type molybdate transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [RHEA:22020]
synonym: "ATPase-coupled molybdate transmembrane transporter activity" RELATED []
synonym: "molybdate ABC transporter" EXACT [EC:7.3.2.5]
synonym: "molybdate porter activity" BROAD []
synonym: "molybdate transmembrane-transporting ATPase activity" RELATED []
synonym: "molybdate transporting ATPase activity" RELATED []
synonym: "molybdate-transporting ATPase activity" RELATED [EC:7.3.2.5]
xref: EC:7.3.2.5
xref: MetaCyc:ABC-19-RXN
xref: RHEA:22020
is_a: GO:0015098 ! molybdate ion transmembrane transporter activity
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015413
name: ABC-type nickel transporter activity
namespace: molecular_function
alt_id: GO:0102016
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [RHEA:15557]
synonym: "ATP-dependent nickel transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled nickel transmembrane transporter activity" RELATED []
synonym: "nickel ABC transporter" EXACT []
synonym: "nickel ABC transporter activity" EXACT []
synonym: "nickel porter activity" RELATED []
synonym: "nickel transporting ATPase activity" RELATED []
synonym: "nickel-transporting ATPase activity" RELATED []
xref: EC:7.2.2.11
xref: MetaCyc:ABC-20-RXN
xref: RHEA:15557
is_a: GO:0015099 ! nickel cation transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015414
name: ABC-type nitrate transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [RHEA:13181]
synonym: "ATPase-coupled nitrate transmembrane transporter activity" RELATED []
synonym: "nitrate ABC transporter" EXACT []
synonym: "nitrate transmembrane-transporting ATPase activity" RELATED []
synonym: "nitrate transporting ATPase activity" RELATED []
synonym: "nitrate-transporting ATPase activity" RELATED [EC:7.3.2.4]
xref: EC:7.3.2.4
xref: MetaCyc:3.6.3.26-RXN
xref: RHEA:13181
is_a: GO:0015112 ! nitrate transmembrane transporter activity
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015415
name: ATPase-coupled phosphate ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:7.3.2.1]
synonym: "ABC phosphate transporter activity" NARROW [EC:7.3.2.1]
synonym: "ATP phosphohydrolase (phosphate-importing)" RELATED [EC:7.3.2.1]
synonym: "phosphate ABC transporter" NARROW []
synonym: "phosphate ion transmembrane-transporting ATPase activity" RELATED []
synonym: "phosphate porter activity" EXACT []
synonym: "phosphate transporting ATPase activity" EXACT []
synonym: "phosphate-transporting ATPase activity" RELATED [EC:7.3.2.1]
xref: EC:7.3.2.1
xref: MetaCyc:ABC-27-RXN
xref: RHEA:24440
is_a: GO:0005315 ! phosphate transmembrane transporter activity
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity

[Term]
id: GO:0015416
name: ABC-type phosphonate transporter activity
namespace: molecular_function
alt_id: GO:0015604
alt_id: GO:0042917
alt_id: GO:0102017
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [RHEA:18065]
synonym: "alkylphosphonate ABC transporter activity" NARROW []
synonym: "alkylphosphonate transmembrane transporter activity" NARROW []
synonym: "alkylphosphonate transmembrane-transporting ATPase activity" NARROW []
synonym: "ATP phosphohydrolase (phosphonate-transporting)" RELATED []
synonym: "ATPase-coupled alkylphosphonate transmembrane transporter activity" NARROW []
synonym: "ATPase-coupled organic phosphonate transmembrane transporter activity" RELATED []
synonym: "organic phosphonate transmembrane transporter activity" BROAD []
synonym: "organic phosphonate transmembrane-transporting ATPase activity" RELATED []
synonym: "phosphonate ABC transporter" EXACT []
synonym: "phosphonate transporting ATPase activity" RELATED []
synonym: "phosphonate-transporting ATPase activity" RELATED []
xref: EC:7.3.2.2
xref: MetaCyc:3.6.3.28-RXN
xref: RHEA:18065
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015417
name: ABC-type polyamine transporter activity
namespace: molecular_function
alt_id: GO:0015595
def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [RHEA:29999]
synonym: "ATP-dependent polyamine transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled polyamine transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled spermidine transmembrane transporter activity" NARROW []
synonym: "polyamine ABC transporter" NARROW [EC:7.6.2.11]
synonym: "polyamine porter activity" BROAD []
synonym: "polyamine-importing ATPase activity" NARROW []
synonym: "polyamine-transporting ATPase activity" RELATED [EC:7.6.2.11]
synonym: "spermidine porter activity" NARROW []
synonym: "spermidine-importing ATPase activity" NARROW []
xref: EC:7.6.2.11
xref: MetaCyc:3.6.3.31-RXN
is_a: GO:0015203 ! polyamine transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015418
name: ABC-type quaternary ammonium compound transporting activity
namespace: molecular_function
alt_id: GO:0102908
def: "Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in)." [GOC:pz, RHEA:11036]
synonym: "ATP-dependent quaternary-ammonium compound transmembrane transporting activity" RELATED []
synonym: "ATPase-coupled quaternary ammonium compound transmembrane transporting activity" RELATED []
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "quarternary amine transporter activity" BROAD []
synonym: "quaternary amine uptake transporter activity" RELATED []
synonym: "quaternary-amine-transporting ATPase activity" RELATED []
synonym: "quaternary-ammonium-compound ABC transporter" EXACT []
synonym: "quaternary-ammonium-compound-transporting ATPase activity" RELATED []
xref: EC:7.6.2.9
xref: MetaCyc:RXN-8638
xref: RHEA:11036
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015419
name: ABC-type sulfate transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [RHEA:10192]
synonym: "ATPase-coupled sulfate transmembrane transporter activity" RELATED []
synonym: "sulfate ABC transporter" EXACT []
synonym: "sulfate transmembrane-transporting ATPase activity" RELATED []
synonym: "sulfate-transporting ATPase activity" RELATED [EC:7.3.2.3]
synonym: "sulfate/thiosulfate porter activity" BROAD []
synonym: "sulphate transporting ATPase activity" RELATED []
xref: MetaCyc:ABC-70-RXN
xref: RHEA:10192
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015420
name: ABC-type vitamin B12 transporter activity
namespace: molecular_function
alt_id: GO:0015235
alt_id: GO:0102023
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin." [GOC:pz, RHEA:17873]
synonym: "ATP-dependent cobalamin transmembrane transporter activity" RELATED []
synonym: "ATP-dependent vitamin B12 transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled cobalamin transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled vitamin B12 transmembrane transporter activity" RELATED []
synonym: "cobalamin ABC transporter" EXACT []
synonym: "cobalamin porter activity" BROAD []
synonym: "cobalamin transporter activity" BROAD []
synonym: "cobalamin-transporting ATPase activity" RELATED []
synonym: "vitamin B12 ABC transporter activity" EXACT []
synonym: "vitamin B12 porter activity" BROAD []
synonym: "vitamin B12 transporter activity" BROAD []
synonym: "vitamin B12-transporting ATPase activity" BROAD []
xref: EC:7.6.2.8
xref: MetaCyc:3.6.3.33-RXN
xref: Reactome:R-HSA-3095901 "ABCC1 transports cytosolic RCbl to extracellular region"
xref: Reactome:R-HSA-5223313 "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)"
xref: Reactome:R-HSA-5683325 "Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-9759206 "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol"
xref: RHEA:17873
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015421
name: ABC-type oligopeptide transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [RHEA:14429]
synonym: "ABC-type oligopeptide transporter" EXACT [EC:7.4.2.6]
synonym: "ATP-dependent oligopeptide transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled oligopeptide transmembrane transporter activity" RELATED []
synonym: "oligopeptide ABC transporter" NARROW []
synonym: "oligopeptide permease activity" RELATED [EC:7.4.2.6]
synonym: "oligopeptide-transporting ATPase activity" RELATED [EC:7.4.2.6]
xref: EC:7.4.2.6
xref: MetaCyc:3.6.3.23-RXN
xref: Reactome:R-HSA-5223317 "ABCB9 transports peptides from cytosol to lysosomal lumen"
xref: RHEA:14429
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015422
name: ABC-type oligosaccharide transporter activity
namespace: molecular_function
alt_id: GO:0015609
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:7.5.2.2]
synonym: "ABC-type oligosaccharide transporter" RELATED [EC:7.5.2.2]
synonym: "ATP-dependent oligosaccharide transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled oligosaccharide transmembrane transporter activity" RELATED []
synonym: "oligosaccharide ABC transporter" EXACT []
synonym: "oligosaccharide-transporting ATPase activity" RELATED [EC:7.5.2.2]
xref: EC:7.5.2.2
xref: MetaCyc:3.6.3.18-RXN
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0043211 ! ABC-type carbohydrate transporter activity

[Term]
id: GO:0015423
name: ABC-type maltose transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [RHEA:22132]
synonym: "ABC-type maltose transporter" EXACT [EC:7.5.2.1]
synonym: "ATP-dependent maltose transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled maltose transmembrane transporter activity" RELATED []
synonym: "maltooligosaccharide-importing ATPase activity" RELATED []
synonym: "maltose ABC transporter" EXACT []
synonym: "maltose-transporting ATPase activity" RELATED [EC:7.5.2.1]
xref: EC:7.5.2.1
xref: MetaCyc:ABC-16-RXN
xref: RHEA:22132
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0015422 ! ABC-type oligosaccharide transporter activity

[Term]
id: GO:0015424
name: ABC-type amino acid transporter activity
namespace: molecular_function
alt_id: GO:0032518
alt_id: GO:0032520
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah]
synonym: "amino acid ABC transporter" NARROW []
synonym: "amino acid-exporting ATPase activity" RELATED []
synonym: "amino acid-importing ATPase activity" RELATED []
synonym: "amino acid-transporting ATPase activity" EXACT []
synonym: "ATP-dependent amino acid transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled amino acid transmembrane transporter activity" RELATED []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015425
name: ATPase-coupled nonpolar-amino acid transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:7.4.2.2]
synonym: "ATP-dependent nonpolar-amino acid transporter activity" EXACT []
synonym: "leucine/isoleucine/valine porter activity" RELATED []
synonym: "nonpolar amino acid-transporting ATPase activity" EXACT []
synonym: "nonpolar-amino acid ABC transporter" EXACT []
synonym: "nonpolar-amino acid-transporting ATPase activity" EXACT []
synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT []
xref: EC:7.4.2.2
xref: MetaCyc:3.6.3.22-RXN
xref: TC:3.A.1.4.1
is_a: GO:0015424 ! ABC-type amino acid transporter activity

[Term]
id: GO:0015426
name: ATPase-coupled polar amino acid-transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:7.4.2.1]
synonym: "ATP-dependent polar amino acid-transporter activity" EXACT []
synonym: "cystine/diaminopimelate porter activity" RELATED []
synonym: "glutamate/aspartate porter activity" RELATED []
synonym: "histidine permease activity" NARROW [EC:7.4.2.1]
synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED []
synonym: "polar amino acid uptake transporter activity" EXACT []
synonym: "polar amino acid-importing ATPase activity" EXACT []
synonym: "polar-amino acid ABC transporter" NARROW []
synonym: "polar-amino acid-importing ATPase activity" EXACT []
synonym: "polar-amino acid-transporting ATPase activity" EXACT []
synonym: "polar-amino-acid-transporting ATPase activity" RELATED [EC:7.4.2.1]
xref: EC:7.4.2.1
xref: MetaCyc:3.6.3.21-RXN
xref: RHEA:14673
is_a: GO:0015424 ! ABC-type amino acid transporter activity

[Term]
id: GO:0015427
name: obsolete ABC-type efflux porter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ABC-type efflux porter activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015428
name: obsolete type I protein secretor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type I protein secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015429
name: obsolete peroxisomal fatty acyl transporter
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and it contains both component and function information.
synonym: "peroxisomal fatty acyl transporter" EXACT []
is_obsolete: true

[Term]
id: GO:0015430
name: ABC-type glycerol-3-phosphate transporter activity
namespace: molecular_function
alt_id: GO:0015610
alt_id: GO:0070812
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [RHEA:21668]
synonym: "ABC-type glycerol 3-phosphate transporter" EXACT [EC:7.6.2.10]
synonym: "ATP-dependent glycerol-2-phosphate transmembrane transporter activity" NARROW []
synonym: "ATPase-coupled glycerol-2-phosphate transmembrane transporter activity" NARROW []
synonym: "ATPase-coupled glycerol-3-phosphate transmembrane transporter activity" RELATED []
synonym: "glycerol phosphate-importing ATPase activity" NARROW []
synonym: "glycerol-2-phosphate-transporting ATPase activity" NARROW []
synonym: "glycerol-3-phosphate ABC transporter" EXACT [EC:7.6.2.10]
synonym: "glycerol-3-phosphate-transporting ATPase" RELATED [EC:7.6.2.10]
synonym: "glycerol-phosphate porter activity" NARROW []
xref: EC:7.6.2.10
xref: MetaCyc:ABC-34-RXN
xref: RHEA:21668
is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015431
name: ABC-type glutathione S-conjugate transporter activity
namespace: molecular_function
alt_id: GO:0071997
def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517, RHEA:19121]
synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT []
synonym: "ATPase-coupled glutathione S-conjugate transmembrane transporter activity" RELATED []
synonym: "conjugate transporter activity" BROAD []
synonym: "glutathione S-conjugate-exporting ATPase activity" NARROW []
synonym: "glutathione S-conjugate-transporting ATPase activity" RELATED [EC:7.6.2.3]
synonym: "GS-X pump" EXACT []
synonym: "MRP1/GS-X pump" EXACT []
xref: EC:7.6.2.3
xref: MetaCyc:TRANS-RXN-358
xref: RHEA:19121
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015432
name: ABC-type bile acid transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate." [RHEA:50048]
synonym: "ATP-dependent bile acid transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled bile acid transmembrane transporter activity" RELATED []
synonym: "bile acid porter activity" NARROW []
synonym: "bile acid-exporting ATPase activity" NARROW []
xref: Reactome:R-HSA-193362 "ABCB11 transports bile salts from cytosol to extracellular region"
xref: Reactome:R-HSA-194153 "ABCC3 transports bile salts from cytosol to extracellular region"
xref: Reactome:R-HSA-5678517 "Defective ABCB11 does not transport bile salts from cytosol to extracellular region"
xref: RHEA:50048
xref: TC:3.A.1.207.2
is_a: GO:0015125 ! bile acid transmembrane transporter activity
is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity
is_a: GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015433
name: ABC-type peptide antigen transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1]
synonym: "ATP-dependent peptide antigen transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled peptide antigen transmembrane transporter activity" RELATED []
synonym: "major histocompatibility peptide transporter activity" EXACT []
synonym: "peptide antigen ABC transporter" NARROW []
synonym: "peptide antigen transporter activity" BROAD []
synonym: "peptide antigen-transporting ATPase activity" EXACT []
xref: EC:7.4.2.14
xref: MetaCyc:3.6.3.43-RXN
xref: Reactome:R-HSA-1236949 "Translocation of antigenic peptides back to phagosomes via TAP"
xref: Reactome:R-HSA-983144 "Transport of Antigen peptide in to ER"
xref: RHEA:65972
xref: TC:3.A.1.209.1
is_a: GO:0015440 ! ABC-type peptide transporter activity

[Term]
id: GO:0015434
name: ABC-type cadmium transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [PMID:12455987]
synonym: "ATP-dependent cadmium transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled cadmium transmembrane transporter activity" RELATED []
synonym: "cadmium ABC transporter" EXACT []
synonym: "cadmium-transporting ATPase activity" RELATED [EC:7.2.2.2]
xref: EC:7.2.2.2
xref: MetaCyc:RXN-21035
is_a: GO:0015086 ! cadmium ion transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015435
name: obsolete ABC-type efflux permease activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ABC-type efflux permease activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015436
name: ABC-type capsular-polysaccharide transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:7.6.2.12]
synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" RELATED [EC:7.6.2.12]
synonym: "ATP-dependent capsular-polysaccharide transporter activity" EXACT []
synonym: "ATPase-coupled capsular-polysaccharide transporter activity" RELATED []
synonym: "capsular-polysaccharide ABC transporter" NARROW []
synonym: "capsular-polysaccharide-transporting ATPase activity" EXACT []
xref: EC:7.6.2.12
xref: MetaCyc:3.6.3.38-RXN
is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015437
name: lipopolysaccharide floppase activity
namespace: molecular_function
def: "Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [EC:7.5.2.5]
synonym: "ATP-dependent intramembrane lipopolysaccharide transporter activity" EXACT []
synonym: "ATPase-coupled intramembrane lipopolysaccharide transporter activity" BROAD []
synonym: "lipopolysaccharide floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
synonym: "lipopolysaccharide-transporting ATPase activity" EXACT []
synonym: "LPS-transporting ATPase activity" EXACT []
is_a: GO:0140328 ! floppase activity

[Term]
id: GO:0015438
name: ABC-type teichoic acid transporter activity
namespace: molecular_function
alt_id: GO:0015162
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [PMID:7565096]
synonym: "ABC-type teichoic-acid transporter" EXACT [EC:7.5.2.4]
synonym: "ATP-dependent teichoic acid transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled teichoic acid transmembrane transporter activity" RELATED []
synonym: "teichoic acid transmembrane transporter activity" BROAD []
synonym: "teichoic-acid ABC transporter" EXACT []
synonym: "teichoic-acid-transporting ATPase activity" RELATED [EC:7.5.2.4]
xref: EC:7.5.2.4
xref: MetaCyc:3.6.3.40-RXN
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015439
name: ABC-type heme transporter activity
namespace: molecular_function
alt_id: GO:0103115
def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [RHEA:19261]
synonym: "ATP-dependent heme transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled heme transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled heme transporter activity" RELATED []
synonym: "haem-transporting ATPase activity" EXACT []
synonym: "heme ABC transporter" NARROW []
synonym: "heme-transporting ATPase activity" EXACT []
synonym: "protoheme IX ABC transporter activity" RELATED []
xref: EC:7.6.2.5
xref: MetaCyc:3.6.3.41-RXN
xref: Reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix"
xref: Reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport"
xref: Reactome:R-HSA-5683355 "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix"
xref: Reactome:R-HSA-917979 "ABCG2 tetramer transports heme from cytosol to extracellular region"
xref: RHEA:19261
is_a: GO:0015232 ! heme transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015440
name: ABC-type peptide transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:7.4.2.5]
synonym: "ATP-dependent peptide transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled peptide transmembrane transporter activity" RELATED []
synonym: "peptide ABC transporter" EXACT []
synonym: "peptide-transporting ATPase activity" RELATED []
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity

[Term]
id: GO:0015441
name: ABC-type beta-glucan transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [RHEA:18453]
synonym: "ABC-type beta-glucan transporter" RELATED [EC:7.5.2.3]
synonym: "ATP-dependent beta-glucan transporter activity" RELATED []
synonym: "ATPase-coupled beta-glucan transporter activity" RELATED []
synonym: "beta-glucan ABC transporter" EXACT []
synonym: "beta-glucan-transporting ATPase activity" RELATED [EC:7.5.2.3]
xref: EC:7.5.2.3
xref: MetaCyc:3.6.3.42-RXN
xref: RHEA:18453
is_a: GO:0015160 ! beta-glucan transmembrane transporter activity
is_a: GO:0043211 ! ABC-type carbohydrate transporter activity

[Term]
id: GO:0015442
name: obsolete hydrogen-/sodium-translocating ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-]
comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification.
synonym: "hydrogen-/sodium-translocating ATPase activity" EXACT []
synonym: "proton-/sodium-translocating ATPase activity" EXACT []
is_obsolete: true
consider: GO:0008553
consider: GO:0008554

[Term]
id: GO:0015443
name: obsolete sodium-transporting two-sector ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15]
comment: This term was made obsolete because it refers to a bifunctional gene product.
synonym: "sodium-transporting two-sector ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046932
consider: GO:0046962

[Term]
id: GO:0015444
name: P-type magnesium transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in)." [RHEA:10260]
synonym: "ATP phosphohydrolase (Mg2+-importing)" RELATED [EC:7.2.2.14]
synonym: "magnesium importing ATPase activity" EXACT []
synonym: "magnesium transmembrane transporter activity, phosphorylative mechanism" RELATED []
synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:7.2.2.14]
synonym: "Mg(2+)-importing ATPase activity" RELATED [EC:7.2.2.14]
synonym: "Mg2+-importing ATPase activity" RELATED [EC:7.2.2.14]
xref: EC:7.2.2.14
xref: MetaCyc:TRANS-RXN-250
xref: RHEA:10260
is_a: GO:0015095 ! magnesium ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0015445
name: P-type silver transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out)." [RHEA:14733]
synonym: "Ag+-exporting ATPase activity" RELATED [EC:7.2.2.15]
synonym: "ATP phosphohydrolase (Ag+-exporting)" RELATED [EC:7.2.2.15]
synonym: "silver exporting ATPase activity" EXACT []
synonym: "silver transmembrane transporter activity, phosphorylative mechanism" EXACT []
synonym: "silver-exporting ATPase activity" RELATED []
xref: EC:7.2.2.15
xref: MetaCyc:3.6.3.53-RXN
xref: RHEA:14733
is_a: GO:0015080 ! silver ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0015446
name: ATPase-coupled arsenite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [PMID:10970874, RHEA:11348]
comment: EC:7.3.2.7 states that this bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. Like ABC transporters, it contains two nucleotide binding sites (PMID:10970874).
synonym: "arsenical pump-driving ATPase activity" RELATED [EC:7.3.2.7]
synonym: "arsenical resistance ATPase activity" RELATED [EC:7.3.2.7]
synonym: "arsenical resistance efflux pump" RELATED []
synonym: "arsenite ABC transporter" NARROW []
synonym: "arsenite transporting ATPase activity" EXACT []
synonym: "arsenite-translocating ATPase activity" RELATED [EC:7.3.2.7]
synonym: "arsenite-transmembrane transporting ATPase activity" RELATED []
synonym: "arsenite-transporting ATPase activity" RELATED [EC:7.3.2.7, GOC:vw]
xref: EC:7.3.2.7
xref: MetaCyc:3.6.3.16-RXN
xref: RHEA:11348
xref: TC:3.A.4.1.1
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
is_a: GO:1901683 ! arsenate ion transmembrane transporter activity

[Term]
id: GO:0015447
name: obsolete type II protein secretor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type II protein secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015448
name: obsolete type III protein (virulence-related) secretor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type III protein (virulence-related) secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015449
name: obsolete type IV protein (DNA-protein) secretor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type IV protein (DNA-protein) secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015450
name: protein-transporting ATPase activity
namespace: molecular_function
def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]
synonym: "P-P-bond-hydrolysis-driven protein transmembrane transporter activity" RELATED []
synonym: "protein translocase activity" EXACT []
xref: Reactome:R-HSA-1222523 "SodB gets secreted"
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0015451
name: decarboxylation-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-]
synonym: "decarboxylation-driven transporter" EXACT []
xref: TC:3.B
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015452
name: methyl transfer-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-]
synonym: "Methyltransfer-driven transporters" EXACT []
xref: TC:3.C
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015453
name: oxidoreduction-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]
synonym: "oxidoreduction-driven transporter" EXACT []
xref: TC:3.D
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015454
name: light-driven active monoatomic ion transmembrane transporter activity
namespace: molecular_function
def: "Active transport of an ion across a membrane, driven by light." [GOC:mtg_transport, PMID:23994288, PMID:26442282]
synonym: "light absorption-driven transporter" EXACT []
synonym: "light-driven active ion transmembrane transporter activity" BROAD []
synonym: "light-driven active transmembrane transporter activity" RELATED []
synonym: "light-driven pumps" EXACT []
xref: TC:3.E
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0015459
name: potassium channel regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a potassium channel." [GOC:dos, GOC:mah]
synonym: "potassium channel gating activity" EXACT []
is_a: GO:0099106 ! ion channel regulator activity

[Term]
id: GO:0015461
name: obsolete endosomal oligosaccharide transporter
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "endosomal oligosaccharide transporter" EXACT []
is_obsolete: true
consider: GO:0005768
consider: GO:0015157

[Term]
id: GO:0015462
name: ABC-type protein transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [GOC:jl]
comment: Enzymes with this activity include bacterial enzymes dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families, for example alpha-hemolysin, cyclolysin, colicin V, siderophores, bacteriocin, subtilin, competence factor and pediocin (from EC:7.4.2.5).
synonym: "ABC-type protein transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled protein transmembrane transporter activity" RELATED []
synonym: "pilin/fimbrilin exporter activity" NARROW []
synonym: "protein ABC transporter" EXACT []
synonym: "protein-transmembrane transporting ATPase activity" RELATED []
synonym: "protein-transporting ATPase activity" BROAD []
is_a: GO:0015450 ! protein-transporting ATPase activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015464
name: acetylcholine receptor activity
namespace: molecular_function
def: "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'.
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity

[Term]
id: GO:0015465
name: obsolete lysin activity
namespace: molecular_function
def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "lysin activity" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015466
name: obsolete autolysin activity
namespace: molecular_function
def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "autolysin activity" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015467
name: G-protein activated inward rectifier potassium channel activity
namespace: molecular_function
alt_id: GO:0015273
def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah]
synonym: "G protein activated inward rectifier potassium channel activity" EXACT []
synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT []
synonym: "G-protein enhanced inward rectifier potassium channel activity" EXACT []
synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT []
synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT []
xref: Reactome:R-HSA-1013020 "Activation of GIRK/Kir3 Channels"
is_a: GO:0005242 ! inward rectifier potassium channel activity

[Term]
id: GO:0015468
name: obsolete colicin
namespace: molecular_function
def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "colicin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005198
consider: GO:0019835
consider: GO:0046930
consider: GO:0046931
consider: GO:0090729

[Term]
id: GO:0015469
name: obsolete channel-forming toxin activity
namespace: molecular_function
def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "channel-forming toxin activity" EXACT []
is_obsolete: true
consider: GO:0015267
consider: GO:0035915
consider: GO:0046930
consider: GO:0090729

[Term]
id: GO:0015470
name: obsolete bacteriocin activity
namespace: molecular_function
def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "bacteriocin activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0019835

[Term]
id: GO:0015471
name: nucleoside-specific channel forming porin activity
namespace: molecular_function
def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015472
name: obsolete fimbrium-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046]
comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function.
synonym: "fimbrium-specific chaperone activity" EXACT []
is_obsolete: true
consider: GO:0009297
consider: GO:0030674
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0015473
name: fimbrial usher porin activity
namespace: molecular_function
def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-]
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015474
name: autotransporter activity
namespace: molecular_function
def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-]
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015475
name: obsolete adhesin autotransporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729]
comment: The reason for obsoletion is that this term represents a specific substrate of the parent GO:0015474 autotransporter activity.
is_obsolete: true
replaced_by: GO:0015474

[Term]
id: GO:0015476
name: obsolete hemaglutinin autotransporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729]
comment: The reason for obsoletion is that this term represents a specific substrate of the parent GO:0015474 autotransporter activity.
is_obsolete: true
replaced_by: GO:0015474

[Term]
id: GO:0015477
name: obsolete receptor porin activity
namespace: molecular_function
def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-]
comment: This term was made obsolete because it combines two functions that are not linked.
synonym: "receptor porin activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015478
name: oligosaccharide transporting porin activity
namespace: molecular_function
def: "Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
synonym: "raffinose porin" NARROW []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015479
name: obsolete outer membrane exporter porin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "outer membrane exporter porin" EXACT []
is_obsolete: true
consider: GO:0009279
consider: GO:0015288

[Term]
id: GO:0015480
name: obsolete secretin (sensu Bacteria)
namespace: molecular_function
def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "secretin (sensu Bacteria)" EXACT []
is_obsolete: true
consider: GO:0008320

[Term]
id: GO:0015481
name: maltose transporting porin activity
namespace: molecular_function
def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
synonym: "maltoporin" EXACT []
xref: Wikipedia:Maltoporin
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015482
name: obsolete voltage-gated anion channel porin activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity.
synonym: "voltage-dependent anion channel porin activity" EXACT []
synonym: "voltage-gated anion channel porin activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015483
name: long-chain fatty acid transporting porin activity
namespace: molecular_function
def: "Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, TC:1.B.9.1.1]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
xref: TC:1.B.9.1.1
is_a: GO:0005324 ! long-chain fatty acid transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015484
name: obsolete hemolysin activity
namespace: molecular_function
def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "hemolysin activity" EXACT []
is_obsolete: true
consider: GO:0019836

[Term]
id: GO:0015485
name: cholesterol binding
namespace: molecular_function
def: "Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]
is_a: GO:0032934 ! sterol binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0015486
name: glycoside-pentoside-hexuronide:cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-]
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity

[Term]
id: GO:0015487
name: melibiose:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1]
synonym: "melibiose permease activity" RELATED []
synonym: "melibiose:cation symporter activity" BROAD []
synonym: "melibiose:monovalent cation symporter activity" EXACT []
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0015156 ! melibiose transmembrane transporter activity

[Term]
id: GO:0015488
name: glucuronide:cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1]
synonym: "glucuronide:monovalent cation symporter activity" EXACT []
synonym: "glucuronoside permease activity" RELATED []
is_a: GO:0015164 ! glucuronoside transmembrane transporter activity
is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity

[Term]
id: GO:0015489
name: putrescine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai]
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015203 ! polyamine transmembrane transporter activity

[Term]
id: GO:0015491
name: obsolete cation:cation antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai]
comment: This term was obsoleted because it was too general for a grouping class.
is_obsolete: true

[Term]
id: GO:0015492
name: phenylalanine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1]
synonym: "phenylalanine:hydrogen symporter activity" EXACT []
is_a: GO:0005280 ! amino acid:proton symporter activity
is_a: GO:0015494 ! aromatic amino acid:proton symporter activity

[Term]
id: GO:0015493
name: lysine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2]
synonym: "lysine:hydrogen symporter activity" EXACT []
is_a: GO:0005280 ! amino acid:proton symporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015494
name: aromatic amino acid:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3]
synonym: "aromatic amino acid:hydrogen symporter activity" EXACT []
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015495
name: gamma-aminobutyric acid:proton symporter activity
namespace: molecular_function
alt_id: GO:0005331
alt_id: GO:0015329
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2]
comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'.
synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT []
synonym: "4-aminobutanoate:proton symporter activity" EXACT []
synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT []
synonym: "4-aminobutyrate:proton symporter activity" EXACT []
synonym: "GABA:hydrogen symporter activity" EXACT []
synonym: "GABA:proton symporter activity" EXACT []
synonym: "gamma-aminobutyric acid permease activity" EXACT []
synonym: "gamma-aminobutyric acid:hydrogen symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-57
xref: Reactome:R-HSA-428625 "Vesicular inhibitory amino acid transport"
xref: RHEA:28915
is_a: GO:0005280 ! amino acid:proton symporter activity
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity

[Term]
id: GO:0015496
name: putrescine:ornithine antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1]
synonym: "putrescine-ornithine antiporter activity" EXACT []
synonym: "putrescine/ornithine antiporter activity" EXACT []
synonym: "putrescine:hydrogen symporter activity" EXACT []
is_a: GO:0000064 ! L-ornithine transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0015489 ! putrescine transmembrane transporter activity

[Term]
id: GO:0015498
name: pantothenate:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1]
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0015499
name: formate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015659
def: "Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai]
synonym: "formate uptake permease activity" EXACT []
synonym: "formate uptake transmembrane transporter activity" RELATED []
xref: MetaCyc:TRANS-RXN-1
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015500
name: obsolete threonine/serine:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "threonine/serine:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005283
consider: GO:0015194
consider: GO:0015195

[Term]
id: GO:0015501
name: glutamate:sodium symporter activity
namespace: molecular_function
alt_id: GO:0008027
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]
synonym: "sodium/excitatory glutamate cotransporter activity" BROAD []
synonym: "sodium/excitatory glutamate symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-122
xref: RHEA:29031
is_a: GO:0005283 ! amino acid:sodium symporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015503
name: glutathione-regulated potassium exporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0015504
name: cytosine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1]
synonym: "cytosine permease activity" RELATED []
synonym: "cytosine:hydrogen ion symporter activity" EXACT []
is_a: GO:0015209 ! cytosine transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015391 ! nucleobase:monoatomic cation symporter activity

[Term]
id: GO:0015505
name: uracil:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport]
synonym: "uracil permease activity" RELATED []
synonym: "uracil:cation symporter activity" BROAD []
is_a: GO:0015210 ! uracil transmembrane transporter activity
is_a: GO:0015391 ! nucleobase:monoatomic cation symporter activity

[Term]
id: GO:0015506
name: nucleoside:proton symporter activity
namespace: molecular_function
alt_id: GO:0015536
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1]
synonym: "nucleoside permease activity" RELATED []
synonym: "nucleoside:hydrogen ion symporter activity" EXACT []
synonym: "nucleoside:hydrogen symporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015507
name: obsolete hydroxy/aromatic amino acid permease activity
namespace: molecular_function
def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
synonym: "hydroxy/aromatic amino acid permease activity" EXACT []
is_obsolete: true
consider: GO:0015171
consider: GO:0015173

[Term]
id: GO:0015513
name: high-affinity secondary active nitrite transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729]
synonym: "nitrite uptake permease activity" EXACT []
is_a: GO:0015112 ! nitrate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015514
name: nitrite efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "nitrite extrusion permease activity" EXACT []
is_a: GO:0015113 ! nitrite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015515
name: citrate:succinate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2]
xref: RHEA:28835
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity

[Term]
id: GO:0015516
name: tartrate:succinate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3]
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0015554 ! tartrate transmembrane transporter activity

[Term]
id: GO:0015517
name: galactose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9]
synonym: "galactose:hydrogen symporter activity" EXACT []
synonym: "lactose, galactose:hydrogen symporter activity" BROAD []
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0009679 ! hexose:proton symporter activity

[Term]
id: GO:0015518
name: arabinose:proton symporter activity
namespace: molecular_function
alt_id: GO:0015523
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2]
synonym: "arabinose efflux permease activity" BROAD []
synonym: "arabinose efflux transmembrane transporter activity" BROAD []
synonym: "arabinose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015519
name: D-xylose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3]
synonym: "D-xylose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0015148 ! D-xylose transmembrane transporter activity

[Term]
id: GO:0015520
name: tetracycline:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4]
synonym: "tetracyclin:hydrogen antiporter activity" EXACT []
synonym: "tetracyclin:proton antiporter activity" EXACT []
synonym: "tetracycline:hydrogen antiporter activity" EXACT []
is_a: GO:0008493 ! tetracycline transmembrane transporter activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0015521
name: obsolete bicyclomycin/sulfathiazole:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" EXACT []
synonym: "bicyclomycin/sulfathiazole:proton antiporter activity" EXACT []
synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT []
is_obsolete: true
consider: GO:0015545
consider: GO:0015546
consider: GO:0045119

[Term]
id: GO:0015522
name: obsolete hydrophobic uncoupler:proton antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9]
comment: The reason for obsoletion is that this term represented a specific protein in TCDB, 2.A.1.2.9, which actually is a sugar transporter that seems to also function as a multidrug efflux protein.
synonym: "hydrophobic uncoupler:hydrogen antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015524
name: obsolete L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15]
comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function.
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" EXACT []
synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity" EXACT []
is_obsolete: true
consider: GO:0015147
consider: GO:0051119

[Term]
id: GO:0015525
name: obsolete carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" EXACT []
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015526
name: hexose-phosphate:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + phosphate(in) = hexose phosphate(in) +  phosphate(out)." [TC:2.A.1.4.1]
synonym: "hexose-phosphate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:phosphate antiporter activity

[Term]
id: GO:0015527
name: glycerol-phosphate:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + phosphate(in) = glycerol phosphate(in) + phosphate(out)." [TC:2.A.1.4.3]
synonym: "glycerol-phosphate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0015315 ! organophosphate:phosphate antiporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015528
name: lactose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1]
synonym: "lactose, galactose:hydrogen symporter activity" BROAD []
synonym: "lactose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0015155 ! lactose transmembrane transporter activity

[Term]
id: GO:0015529
name: raffinose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2]
synonym: "raffinose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0015158 ! raffinose transmembrane transporter activity

[Term]
id: GO:0015530
name: shikimate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015531
name: citrate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1]
synonym: "citrate:hydrogen symporter activity" EXACT []
xref: RHEA:32123
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity

[Term]
id: GO:0015532
name: alpha-ketoglutarate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2]
synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT []
synonym: "2-oxoglutarate:proton symporter activity" EXACT []
synonym: "alpha-ketoglutarate:hydrogen symporter activity" EXACT []
is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015533
name: shikimate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6]
synonym: "shikimate:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity
is_a: GO:0015530 ! shikimate transmembrane transporter activity

[Term]
id: GO:0015534
name: obsolete proline/glycine/betaine:hydrogen/sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" EXACT []
synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT []
is_obsolete: true
consider: GO:0015187
consider: GO:0015193
consider: GO:0015199
consider: GO:0015294
consider: GO:0015295
consider: GO:0015370

[Term]
id: GO:0015535
name: fucose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1]
synonym: "fucose:hydrogen symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-20
xref: RHEA:29023
is_a: GO:0009679 ! hexose:proton symporter activity
is_a: GO:0015150 ! fucose transmembrane transporter activity

[Term]
id: GO:0015537
name: xanthosine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2]
synonym: "xanthosine permease activity" RELATED []
synonym: "xanthosine:hydrogen ion symporter activity" EXACT []
is_a: GO:0015506 ! nucleoside:proton symporter activity
is_a: GO:0015553 ! xanthosine transmembrane transporter activity

[Term]
id: GO:0015538
name: sialic acid:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1]
synonym: "sialic acid permease activity" RELATED []
synonym: "sialic acid:hydrogen symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-25
xref: Reactome:R-HSA-428585 "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-5624239 "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol"
xref: RHEA:28987
is_a: GO:0015136 ! sialic acid transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015539
name: hexuronate:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2]
synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW []
synonym: "hexuronate porter activity" RELATED []
synonym: "hexuronate:cation symporter activity" BROAD []
is_a: GO:0015294 ! solute:monoatomic cation symporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015540
name: 3-hydroxyphenyl propionate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2]
synonym: "3-hydroxyphenyl propionate porter activity" RELATED []
synonym: "3-hydroxyphenyl propionate:hydrogen ion symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity

[Term]
id: GO:0015541
name: secondary active cyanate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cyanate from one side of a membrane to the other." [TC:2.A.1.17.1]
synonym: "cyanate porter activity" RELATED []
is_a: GO:0015110 ! cyanate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015543
name: obsolete lactose/glucose efflux transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "lactose/glucose efflux transporter activity" EXACT []
is_obsolete: true
consider: GO:0015155

[Term]
id: GO:0015544
name: phenyl propionate uniporter activity
namespace: molecular_function
def: "Enables the transfer of phenyl propionate from one side of a membrane to the other." [GOC:mtg_transport, TC:2.A.1.27.1]
synonym: "phenyl propionate permease activity" RELATED []
is_a: GO:0015292 ! uniporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity
is_a: GO:0015552 ! propionate transmembrane transporter activity

[Term]
id: GO:0015545
name: bicyclomycin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:091191028X]
synonym: "bicyclomycin transporter activity" RELATED []
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015546
name: sulfathiazole transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group." [GOC:curators]
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED []
synonym: "sulphathiazole transporter activity" EXACT []
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015547
name: obsolete nalidixic acid transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of nalidixic acid from one side of a membrane to the other. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221]
comment: The reason for obsoletion is that these terms are beyond the scope of GO.
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED []
synonym: "nalidixic acid transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0015548
name: obsolete organomercurial transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
synonym: "organomercurial transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0015549
name: obsolete carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of carbonyl cyanide m-chlorophenylhydrazone from one side of a membrane to the other. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [GOC:curators]
comment: The reason for obsoletion is that these terms are beyond the scope of GO.
synonym: "carbonyl cyanide m-chlorophenylhydrazone transporter activity" RELATED []
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED []
synonym: "CCCP transporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015550
name: galacturonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015551
name: 3-hydroxyphenyl propanoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other." [GOC:ai]
synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT []
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015552
name: propionate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai]
is_a: GO:0015636 ! short-chain fatty acid transmembrane transporter activity

[Term]
id: GO:0015553
name: xanthosine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732]
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity

[Term]
id: GO:0015554
name: tartrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai]
is_a: GO:1901702 ! salt transmembrane transporter activity

[Term]
id: GO:0015556
name: C4-dicarboxylate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of C4-dicarboxylate from one side of a membrane to the other." [GOC:krc]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015558
name: secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015569
def: "Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai]
synonym: "p-aminobenzoyl-glutamate transmembrane transporter activity" NARROW []
synonym: "p-aminobenzoyl-glutamate transporter activity" RELATED []
synonym: "p-aminobenzoyl-glutamate uptake permease activity" RELATED []
synonym: "p-aminobenzoyl-glutamate uptake transmembrane transporter activity" RELATED []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0071916 ! dipeptide transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0015560
name: obsolete L-idonate/D-gluconate:hydrogen symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" EXACT []
synonym: "L-idonate/D-gluconate:proton symporter" EXACT []
is_obsolete: true
consider: GO:0015128
consider: GO:0015295
consider: GO:0015568

[Term]
id: GO:0015561
name: rhamnose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6]
synonym: "rhamnose:hydrogen symporter activity" EXACT []
xref: TC:2.A.7.6
is_a: GO:0009679 ! hexose:proton symporter activity
is_a: GO:0015153 ! rhamnose transmembrane transporter activity

[Term]
id: GO:0015562
name: efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "efflux permease activity" EXACT []
synonym: "efflux transporter activity" EXACT [GOC:cjm]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015565
name: threonine efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "threonine efflux permease activity" EXACT []
synonym: "threonine export protein" RELATED []
synonym: "threonine export transporter activity" EXACT []
is_a: GO:0015195 ! L-threonine transmembrane transporter activity
is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity

[Term]
id: GO:0015566
name: obsolete acriflavine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015555
def: "OBSOLETE. Enables the directed movement of acriflavin from one side of a membrane to the other. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [PubChem_Compound:6842]
comment: The reason for obsoletion is that these terms are beyond the scope of GO.
synonym: "acriflavin resistant pump activity" RELATED [GOC:dph, GOC:tb]
synonym: "acriflavin transporter activity" RELATED [GOC:dph, GOC:tb]
synonym: "acriflavine transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0015567
name: alkane transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015568
name: L-idonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai]
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0015571
name: N-acetylgalactosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015590
def: "Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "N-acetylgalactosamine permease activity" EXACT []
is_a: GO:0019196 ! galactosamine transmembrane transporter activity

[Term]
id: GO:0015572
name: N-acetylglucosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015580
def: "Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "D-GlcNAc transmembrane transporter activity" EXACT []
synonym: "N-Acetyl-D-glucosamine permease" RELATED []
synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT []
synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT []
synonym: "N-acetylglucosamine permease activity" RELATED []
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015573
name: beta-glucoside transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015582
def: "Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:7883710]
synonym: "beta-glucoside permease activity" EXACT []
is_a: GO:0042947 ! glucoside transmembrane transporter activity

[Term]
id: GO:0015574
name: trehalose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015584
def: "Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "trehalose permease activity" EXACT []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0015575
name: mannitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015586
def: "Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "mannitol permease activity" EXACT []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015576
name: sorbitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015587
def: "Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732]
synonym: "glucitol permease activity" EXACT []
synonym: "glucitol transporter activity" EXACT []
synonym: "sorbitol permease activity" EXACT []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0015577
name: galactitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015588
def: "Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "galactitol permease activity" EXACT []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015578
name: mannose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015589
def: "Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "mannose permease activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015583
name: obsolete beta-glucoside [arbutin-salicin-cellobiose] permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it arbitrarily groups three substrates.
synonym: "beta-glucoside [arbutin-salicin-cellobiose] permease activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015591
name: D-ribose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0015146 ! pentose transmembrane transporter activity

[Term]
id: GO:0015592
name: methylgalactoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:mtg_transport, ISBN:0815340729]
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015593
name: obsolete allose transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true
consider: GO:0015615
consider: GO:0055056

[Term]
id: GO:0015594
name: ABC-type putrescine transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)." [EC:7.6.2.11]
synonym: "ATPase-coupled putrescine transmembrane transporter activity" RELATED []
synonym: "putrescine porter activity" BROAD []
synonym: "putrescine-importing ATPase activity" NARROW []
xref: EC:7.6.2.16
xref: MetaCyc:ABC-25-RXN
xref: RHEA:29995
is_a: GO:0015417 ! ABC-type polyamine transporter activity
is_a: GO:0015489 ! putrescine transmembrane transporter activity

[Term]
id: GO:0015596
name: obsolete glycine betaine/proline porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "glycine betaine/proline porter activity" EXACT []
is_obsolete: true
consider: GO:0015187
consider: GO:0015193
consider: GO:0015199
consider: GO:0015418

[Term]
id: GO:0015597
name: obsolete histidine/arginine/lysine/ornithine porter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "histidine/arginine/lysine/ornithine porter activity" EXACT []
is_obsolete: true
consider: GO:0000064
consider: GO:0005290
consider: GO:0015189
consider: GO:0015426
consider: GO:0061459

[Term]
id: GO:0015599
name: ATPase-coupled L-glutamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)." [RHEA:29895]
synonym: "ATPase-coupled glutamine transmembrane transporter activity" BROAD []
synonym: "glutamine porter activity" BROAD []
synonym: "glutamine-importing ATPase activity" RELATED []
xref: MetaCyc:ABC-12-RXN
xref: RHEA:29895
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity
is_a: GO:0015426 ! ATPase-coupled polar amino acid-transporter activity
is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015600
name: obsolete glutamate/aspartate porter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "glutamate/aspartate porter activity" EXACT []
is_obsolete: true
consider: GO:0005313
consider: GO:0015183
consider: GO:0015426

[Term]
id: GO:0015601
name: obsolete cystine/diaminopimelate porter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "cystine/diaminopimelate porter activity" EXACT []
is_obsolete: true
consider: GO:0015184
consider: GO:0015426
consider: GO:0015626

[Term]
id: GO:0015602
name: obsolete leucine/isoleucine/valine porter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "leucine/isoleucine/valine porter activity" EXACT []
is_obsolete: true
consider: GO:0005304
consider: GO:0015188
consider: GO:0015190
consider: GO:0015425

[Term]
id: GO:0015603
name: iron chelate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [PMID:17660286]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015605
name: organophosphate ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015606
name: spermidine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015203 ! polyamine transmembrane transporter activity

[Term]
id: GO:0015607
name: ABC-type fatty-acyl-CoA transporter activity
namespace: molecular_function
def: "Catalysis of the reaction ATP + H2O + fatty acyl CoA(Side 1) = ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it." [RHEA:15181]
synonym: "ABC-type fatty-acyl-CoA transporter" EXACT []
synonym: "ATPase-coupled fatty-acyl-CoA transmembrane transporter activity" RELATED []
synonym: "fatty acyl CoA transporter activity" RELATED []
synonym: "fatty-acyl-CoA transmembrane transporter activity" BROAD []
synonym: "fatty-acyl-CoA-transporting ATPase" RELATED [EC:7.6.2.4]
xref: EC:7.6.2.4
xref: MetaCyc:3.6.3.47-RXN
xref: RHEA:15181
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015608
name: carbohydrate-importing ABC transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)." [GOC:ai]
synonym: "carbohydrate uptake transporter activity" EXACT []
synonym: "carbohydrate-importing ATPase activity" BROAD []
synonym: "sugar transporter" NARROW []
xref: TC:3.A.1.1.1
is_a: GO:0043211 ! ABC-type carbohydrate transporter activity

[Term]
id: GO:0015611
name: ABC-type D-ribose transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) = ADP + phosphate + D-ribose(in)." [RHEA:29903]
synonym: "D-ribose porter activity" BROAD []
synonym: "D-ribose-importing ATPase activity" RELATED []
xref: EC:7.5.2.7
xref: MetaCyc:ABC-28-RXN
xref: RHEA:29903
is_a: GO:0015407 ! ABC-type monosaccharide transporter activity
is_a: GO:0015591 ! D-ribose transmembrane transporter activity

[Term]
id: GO:0015612
name: ABC-type L-arabinose transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) = ADP + phosphate + L-arabinose(in)." [RHEA:30007]
synonym: "L-arabinose porter activity" EXACT []
synonym: "L-arabinose-importing ATPase activity" NARROW []
xref: EC:7.5.2.12
xref: MetaCyc:ABC-2-RXN
xref: RHEA:30007
is_a: GO:0015147 ! L-arabinose transmembrane transporter activity
is_a: GO:0015407 ! ABC-type monosaccharide transporter activity

[Term]
id: GO:0015613
name: obsolete galactose/glucose (methylgalactoside) porter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "galactose/glucose (methylgalactoside) porter activity" EXACT []
is_obsolete: true
consider: GO:0005354
consider: GO:0015291
consider: GO:0015592

[Term]
id: GO:0015614
name: ABC-type D-xylose transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in)." [RHEA:29899]
synonym: "ATPase-coupled D-xylose transmembrane transporter activity" RELATED []
synonym: "D-xylose porter activity" BROAD []
synonym: "D-xylose-importing ATPase activity" RELATED []
xref: EC:7.5.2.10
xref: MetaCyc:ABC-33-RXN
xref: RHEA:29899
is_a: GO:0015148 ! D-xylose transmembrane transporter activity
is_a: GO:0015407 ! ABC-type monosaccharide transporter activity

[Term]
id: GO:0015615
name: ABC-type D-allose transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) = ADP + phosphate + D-allose(in)." [PMID:9401019, RHEA:29799]
synonym: "D-allose porter activity" BROAD []
synonym: "D-allose-importing ATPase activity" RELATED []
xref: EC:7.5.2.8
xref: RHEA:29799
is_a: GO:0015149 ! hexose transmembrane transporter activity
is_a: GO:0015407 ! ABC-type monosaccharide transporter activity

[Term]
id: GO:0015616
name: DNA translocase activity
namespace: molecular_function
def: "Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis." [GOC:mah, PMID:16428451, PMID:17631491]
comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0015617
name: obsolete pilin/fimbrilin exporter activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "pilin/fimbrilin exporter activity" EXACT []
is_obsolete: true
consider: GO:0015462

[Term]
id: GO:0015620
name: ferric-enterobactin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity

[Term]
id: GO:0015621
name: ferric triacetylfusarinine C transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015624
name: ABC-type ferric-enterobactin transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [RHEA:58492]
synonym: "ATP-dependent ferric-enterobactin transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled ferric-enterobactin transmembrane transporter activity" RELATED []
synonym: "ferric-enterobactin ABC transporter" EXACT []
synonym: "ferric-enterobactin porter activity" BROAD []
synonym: "ferric-enterobactin-transporting ATPase activity" RELATED []
xref: EC:7.2.2.17
xref: MetaCyc:ABC-10-RXN
xref: RHEA:58492
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015603 ! iron chelate transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015625
name: ABC-type ferric hydroxamate transporter activity
namespace: molecular_function
alt_id: GO:0015409
alt_id: GO:0015622
alt_id: GO:0015623
alt_id: GO:0102026
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [PMID:1551849]
synonym: "ATP-dependent ferric-hydroxamate transmembrane transporter activity" EXACT []
synonym: "ATP-dependent iron-chelate transporter activity" BROAD []
synonym: "ATPase-coupled ferric-hydroxamate transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled iron-chelate transporter activity" BROAD []
synonym: "ferric-hydroxamate ABC transporter" NARROW []
synonym: "ferric-hydroxamate porter activity" BROAD []
synonym: "ferric-hydroxamate transmembrane transporter activity" BROAD []
synonym: "ferric-hydroxamate-transporting ATPase activity" EXACT []
synonym: "iron-chelate-transporting ATPase activity" BROAD []
xref: EC:7.2.2.16
xref: MetaCyc:ABC-11-RXN
is_a: GO:0015603 ! iron chelate transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015626
name: L-diaminopimelate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "cystine/diaminopimelate porter activity" NARROW []
synonym: "L-diaminopimelate transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015627
name: type II protein secretion system complex
namespace: cellular_component
def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494]
comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'.
synonym: "general secretion pathway-associated complex" RELATED []
synonym: "main terminal branch" EXACT []
synonym: "MTB" EXACT []
synonym: "Sec-dependent secretion system-associated complex" RELATED []
synonym: "T2SS-associated complexes" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0015628
name: protein secretion by the type II secretion system
namespace: biological_process
def: "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted.
synonym: "protein secretion by the general secretion pathway" RELATED []
synonym: "protein secretion by the general secretory pathway" RELATED []
synonym: "protein secretion by the T2S" EXACT []
synonym: "protein secretion by the T2SS" EXACT []
synonym: "protein secretion by the type II protein secretion system" EXACT []
synonym: "type II protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0098776 ! protein transport across the cell outer membrane

[Term]
id: GO:0015629
name: actin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015630
name: microtubule cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015631
name: tubulin binding
namespace: molecular_function
def: "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0015633
name: ABC-type zinc transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [RHEA:29795]
synonym: "ATP-dependent zinc transmembrane transporter activity" BROAD []
synonym: "ATPase-coupled zinc transmembrane transporter activity" BROAD []
synonym: "zinc porter activity" RELATED []
synonym: "zinc transporting ATPase activity" BROAD []
synonym: "zinc-transporting ATPase activity" BROAD []
xref: EC:7.2.2.20
xref: MetaCyc:ABC-63-RXN
xref: RHEA:29795
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0015634
name: obsolete lipopolysaccharide exporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was obsoleted because export is a process, not a function.
synonym: "LPS exporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015636
name: short-chain fatty acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015635
def: "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:mah]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "short-chain fatty acid transporter activity" RELATED []
synonym: "short-chain fatty acid uptake transporter activity" RELATED []
is_a: GO:0015245 ! fatty acid transmembrane transporter activity

[Term]
id: GO:0015638
name: microcin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a microcin from one side of a membrane to the other." [GOC:mah]
synonym: "microcin uptake permease activity" EXACT []
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0042910 ! xenobiotic transmembrane transporter activity

[Term]
id: GO:0015640
name: peptidoglycan peptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732]
synonym: "murein peptide transporter activity" EXACT []
synonym: "muropeptide transporter activity" EXACT []
is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity

[Term]
id: GO:0015641
name: obsolete lipoprotein toxin
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "lipoprotein toxin" EXACT []
is_obsolete: true
consider: GO:0090729

[Term]
id: GO:0015642
name: obsolete bacteriolytic toxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl]
comment: This term was made obsolete because it represents a class of gene products and not a molecular function.
synonym: "bacteriolytic toxin activity" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015643
name: toxic substance binding
namespace: molecular_function
def: "Binding to a toxic substance, a poisonous substance that causes damage to biological systems." [GOC:bf, GOC:curators, GOC:jl, GOC:pr]
synonym: "antitoxin activity" RELATED []
synonym: "lipoprotein antitoxin" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0015644
name: obsolete lipoprotein antitoxin
namespace: molecular_function
def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl]
comment: This term was made obsolete because it does not represent a function distinct from its parent term.
synonym: "lipoprotein antitoxin" EXACT []
is_obsolete: true
replaced_by: GO:0015643

[Term]
id: GO:0015645
name: fatty acid ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah]
synonym: "fatty acid CoA ligase activity" RELATED []
synonym: "fatty acyl-coenzyme A synthetase activity" RELATED []
synonym: "fatty-acid ligase activity" EXACT []
is_a: GO:0016878 ! acid-thiol ligase activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0015647
name: peptidoglycan transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other." [GOC:ai]
synonym: "murein transporter activity" EXACT []
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015648
name: lipid-linked peptidoglycan transporter activity
namespace: molecular_function
def: "Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells." [GOC:mah]
synonym: "lipid-linked murein transporter activity" EXACT []
is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity

[Term]
id: GO:0015649
name: 2-keto-3-deoxygluconate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [RHEA:29943, TC:2.A.10.1.1]
synonym: "2-keto-3-deoxygluconate:hydrogen symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-113
xref: RHEA:29943
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity

[Term]
id: GO:0015650
name: lactate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1]
synonym: "lactate permease" BROAD []
synonym: "lactate:hydrogen porter activity" EXACT []
synonym: "lactate:hydrogen symporter activity" EXACT []
synonym: "lactate:proton porter activity" EXACT []
is_a: GO:0015129 ! lactate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity

[Term]
id: GO:0015651
name: quaternary ammonium group transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015202
def: "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732]
synonym: "quaternary amine transmembrane transporter activity" EXACT []
synonym: "quaternary ammonium compound transporter activity" EXACT []
is_a: GO:0015101 ! organic cation transmembrane transporter activity

[Term]
id: GO:0015652
name: quaternary ammonium group:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai]
synonym: "quaternary ammonium group:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity

[Term]
id: GO:0015653
name: glycine betaine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1]
synonym: "glycine betaine:hydrogen symporter activity" EXACT []
is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity
is_a: GO:0015652 ! quaternary ammonium group:proton symporter activity

[Term]
id: GO:0015654
name: tellurite transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015118
def: "Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [GOC:ai]
synonym: "tellurite uptake transmembrane transporter activity" RELATED []
synonym: "tellurite-resistance uptake permease activity" RELATED []
synonym: "tellurite-resistance uptake transmembrane transporter activity" RELATED []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015655
name: alanine:sodium symporter activity
namespace: molecular_function
alt_id: GO:0044670
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai]
synonym: "sodium:alanine symporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-125
xref: RHEA:29283
is_a: GO:0005283 ! amino acid:sodium symporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0022858 ! alanine transmembrane transporter activity

[Term]
id: GO:0015657
name: branched-chain amino acid:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1]
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity

[Term]
id: GO:0015658
name: branched-chain amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901240
def: "Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729]
synonym: "branched-chain aliphatic amino acid transmembrane transporter activity" EXACT [GOC:bf]
synonym: "branched-chain aliphatic amino acid transporter activity" EXACT []
synonym: "leucine/valine/isoleucine permease activity" RELATED []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
xref: Reactome:R-HSA-9672770 "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015660
name: formate efflux transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015509
def: "Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "formate efflux permease activity" RELATED []
is_a: GO:0015499 ! formate transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015661
name: L-lysine efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-lysine exporter activity" EXACT []
synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT []
is_a: GO:0015189 ! L-lysine transmembrane transporter activity
is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity

[Term]
id: GO:0015662
name: P-type ion transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]
synonym: "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" EXACT []
synonym: "ion transmembrane transporter activity, phosphorylative mechanism" RELATED []
synonym: "P-type ATPase activity" EXACT []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
is_a: GO:0140358 ! P-type transmembrane transporter activity

[Term]
id: GO:0015663
name: nicotinamide mononucleotide transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015664
def: "Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544]
synonym: "nicotinamide mononucleotide permease activity" RELATED []
synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT []
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0015665
name: alcohol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732]
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015666
name: restriction endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg]
synonym: "restriction endonuclease activity" EXACT []
synonym: "restriction enzyme activity" EXACT []
is_a: GO:0004520 ! DNA endonuclease activity

[Term]
id: GO:0015667
name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113]
synonym: "DNA[cytosine-N4]methyltransferase activity" RELATED [EC:2.1.1.113]
synonym: "m4C-forming MTase activity" RELATED [EC:2.1.1.113]
synonym: "modification methylase activity" RELATED [EC:2.1.1.113]
synonym: "N(4)-cytosine-specific DNA methylase activity" RELATED [EC:2.1.1.113]
synonym: "N4-cytosine-specific DNA methylase activity" RELATED [EC:2.1.1.113]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113]
synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" RELATED [EC:2.1.1.113]
synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" RELATED [EC:2.1.1.113]
xref: EC:2.1.1.113
xref: MetaCyc:2.1.1.113-RXN
xref: RHEA:16857
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity

[Term]
id: GO:0015668
name: type III site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995]
synonym: "type III restriction enzyme activity" EXACT []
xref: EC:3.1.21.5
xref: MetaCyc:3.1.21.5-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0015669
name: gas transport
namespace: biological_process
def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0015670
name: carbon dioxide transport
namespace: biological_process
def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015669 ! gas transport
is_a: GO:0019755 ! one-carbon compound transport

[Term]
id: GO:0015671
name: oxygen transport
namespace: biological_process
def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015669 ! gas transport

[Term]
id: GO:0015673
name: silver ion transport
namespace: biological_process
def: "The directed movement of silver (Ag+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "silver transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015675
name: nickel cation transport
namespace: biological_process
def: "The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015676
name: vanadium ion transport
namespace: biological_process
def: "The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015677
name: copper ion import
namespace: biological_process
def: "The directed movement of copper ions into a cell or organelle." [GOC:ai]
synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006825 ! copper ion transport

[Term]
id: GO:0015679
name: plasma membrane copper ion transport
namespace: biological_process
def: "The directed movement of copper ions across the plasma membrane." [GOC:ai]
synonym: "plasma membrane copper transport" EXACT []
is_a: GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0015680
name: protein maturation by copper ion transfer
namespace: biological_process
def: "A process that contributes to the delivery of copper ions to a target protein." [GOC:ai]
synonym: "intracellular copper delivery" EXACT []
synonym: "intracellular copper ion delivery" RELATED []
synonym: "intracellular copper ion transport" BROAD []
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0015685
name: ferric-enterobactin import into cell
namespace: biological_process
def: "A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658]
synonym: "ferric-enterobactin transport" BROAD []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0033214 ! siderophore-dependent iron import into cell

[Term]
id: GO:0015686
name: ferric triacetylfusarinine C import into cell
namespace: biological_process
def: "The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "ferric triacetylfusarinine C transport" BROAD []
is_a: GO:0033214 ! siderophore-dependent iron import into cell
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015687
name: ferric-hydroxamate import into cell
namespace: biological_process
def: "A process in which ferric-hydroxamate, the iron-bound form of the iron chelator hydroxamate, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658]
synonym: "ferric-hydroxamate transport" BROAD []
is_a: GO:0033214 ! siderophore-dependent iron import into cell

[Term]
id: GO:0015689
name: molybdate ion transport
namespace: biological_process
def: "The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015690
name: aluminum cation transport
namespace: biological_process
def: "The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "aluminium ion transport" EXACT []
synonym: "aluminium transport" EXACT []
synonym: "aluminum ion transport" RELATED []
synonym: "aluminum transport" EXACT []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0015691
name: cadmium ion transport
namespace: biological_process
def: "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "cadmium transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015692
name: lead ion transport
namespace: biological_process
def: "The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0015693
name: magnesium ion transport
namespace: biological_process
def: "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "magnesium transport" RELATED []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0015694
name: mercury ion transport
namespace: biological_process
def: "The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "mercuric ion transport" NARROW []
synonym: "mercury transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
relationship: part_of GO:0050787 ! detoxification of mercury ion

[Term]
id: GO:0015695
name: organic cation transport
namespace: biological_process
def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015697
name: quaternary ammonium group transport
namespace: biological_process
alt_id: GO:0015845
def: "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732]
synonym: "quaternary amine transport" EXACT []
synonym: "quaternary ammonium compound transport" EXACT []
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015698
name: inorganic anion transport
namespace: biological_process
def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015699
name: antimonite transmembrane transport
namespace: biological_process
def: "The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "antimonite transport" BROAD []
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:0015700
name: arsenite transport
namespace: biological_process
def: "The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015701
name: bicarbonate transport
namespace: biological_process
def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "hydrogencarbonate transport" EXACT []
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015702
name: chlorate transport
namespace: biological_process
def: "The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015703
name: chromate transport
namespace: biological_process
def: "The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015704
name: cyanate transport
namespace: biological_process
def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0019755 ! one-carbon compound transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015705
name: iodide transport
namespace: biological_process
def: "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006820 ! monoatomic anion transport
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015706
name: nitrate transmembrane transport
namespace: biological_process
alt_id: GO:0006872
alt_id: GO:0080055
def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "low affinity nitrate transport" NARROW []
synonym: "low-affinity nitrate transport" NARROW []
synonym: "nitrate transport" BROAD []
is_a: GO:0098661 ! inorganic anion transmembrane transport
is_a: GO:1902025 ! nitrate import

[Term]
id: GO:0015707
name: nitrite transport
namespace: biological_process
def: "The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015708
name: silicic acid import across plasma membrane
namespace: biological_process
alt_id: GO:0051207
alt_id: GO:1902067
def: "The directed movement of silicates from outside of a cell, across the plasma membrane and into the cytosol. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, GOC:krc, PMID:16572174]
synonym: "silicate transport" BROAD []
synonym: "silicic acid import" RELATED []
synonym: "silicic acid transport" EXACT []
synonym: "silicon uptake" RELATED []
is_a: GO:0098658 ! inorganic anion import across plasma membrane

[Term]
id: GO:0015709
name: thiosulfate transport
namespace: biological_process
def: "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "thiosulphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015710
name: tellurite transport
namespace: biological_process
def: "The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015711
name: organic anion transport
namespace: biological_process
def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015712
name: hexose phosphate transport
namespace: biological_process
def: "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015713
name: phosphoglycerate transmembrane transport
namespace: biological_process
def: "The process in which phosphoglycerate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc]
synonym: "phosphoglycerate transport" RELATED []
is_a: GO:0042873 ! aldonate transmembrane transport

[Term]
id: GO:0015714
name: phosphoenolpyruvate transport
namespace: biological_process
def: "The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015748 ! organophosphate ester transport

[Term]
id: GO:0015715
name: nucleotide-sulfate transport
namespace: biological_process
def: "The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "nucleotide-sulphate transport" EXACT []
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015716
name: organic phosphonate transport
namespace: biological_process
alt_id: GO:0042916
def: "The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc]
synonym: "alkylphosphonate transport" NARROW []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015717
name: triose phosphate transport
namespace: biological_process
def: "The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "aldotriose phosphate transport" EXACT []
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015718
name: monocarboxylic acid transport
namespace: biological_process
def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0015719
name: allantoate transport
namespace: biological_process
def: "The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "allantoin/allantoate transport" BROAD []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015720
name: allantoin transport
namespace: biological_process
def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "allantoin transmembrane transport" EXACT [GOC:mah]
synonym: "allantoin/allantoate transport" BROAD []
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015721
name: bile acid and bile salt transport
namespace: biological_process
def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]
synonym: "bile acid transport" NARROW []
synonym: "bile salt transport" NARROW []
is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015722
name: canalicular bile acid transport
namespace: biological_process
def: "Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph]
is_a: GO:0015721 ! bile acid and bile salt transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0015723
name: bilirubin transport
namespace: biological_process
def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015724
name: formate transport
namespace: biological_process
def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015726
name: L-idonate transmembrane transport
namespace: biological_process
def: "The process in which L-idonate is transported across a lipid bilayer, from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc]
synonym: "L-idonate transport" RELATED []
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0042873 ! aldonate transmembrane transport

[Term]
id: GO:0015727
name: lactate transport
namespace: biological_process
def: "The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015728
name: mevalonate transport
namespace: biological_process
def: "The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015729
name: oxaloacetate transport
namespace: biological_process
def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015730
name: propanoate transmembrane transport
namespace: biological_process
def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "propanoate transport" BROAD []
synonym: "propionate transport" EXACT []
is_a: GO:0015913 ! short-chain fatty acid transmembrane transport

[Term]
id: GO:0015731
name: 3-hydroxyphenyl propanoate transport
namespace: biological_process
def: "The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "3-hydroxyphenyl propionate transport" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015732
name: prostaglandin transport
namespace: biological_process
def: "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015908 ! fatty acid transport
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:0015733
name: shikimate transmembrane transport
namespace: biological_process
def: "The process in which shikimate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc]
synonym: "shikimate transport" RELATED []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015734
name: taurine transmembrane transport
namespace: biological_process
def: "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "taurine transport" BROAD []
is_a: GO:0042918 ! alkanesulfonate transmembrane transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015735
name: uronic acid transmembrane transport
namespace: biological_process
def: "The process in which uronic acid is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc]
synonym: "uronic acid transport" RELATED []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015736
name: hexuronate transmembrane transport
namespace: biological_process
def: "The process in which hexuronate is transported across a lipid bilayer, from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732]
synonym: "hexuronate transport" RELATED []
is_a: GO:0015735 ! uronic acid transmembrane transport

[Term]
id: GO:0015737
name: galacturonate transmembrane transport
namespace: biological_process
def: "The process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc]
synonym: "galacturonate transport" RELATED []
is_a: GO:0015736 ! hexuronate transmembrane transport

[Term]
id: GO:0015738
name: glucuronate transmembrane transport
namespace: biological_process
def: "The process in which glucuronate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc]
synonym: "glucuronate transport" RELATED []
is_a: GO:0015736 ! hexuronate transmembrane transport

[Term]
id: GO:0015739
name: sialic acid transport
namespace: biological_process
def: "The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0015740
name: C4-dicarboxylate transport
namespace: biological_process
def: "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah]
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0015741
name: fumarate transport
namespace: biological_process
def: "The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015742
name: alpha-ketoglutarate transport
namespace: biological_process
def: "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "2-oxoglutarate transport" EXACT []
synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED []
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0015743
name: malate transport
namespace: biological_process
def: "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED []
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015744
name: succinate transport
namespace: biological_process
def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015745
name: tartrate transmembrane transport
namespace: biological_process
def: "The process in which tartrate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc]
synonym: "tartrate transport" RELATED []
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0042869 ! aldarate transmembrane transport

[Term]
id: GO:0015746
name: citrate transport
namespace: biological_process
def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006842 ! tricarboxylic acid transport

[Term]
id: GO:0015747
name: urate transport
namespace: biological_process
def: "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "urate transmembrane transport" EXACT [GOC:mah]
synonym: "uric acid transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015748
name: organophosphate ester transport
namespace: biological_process
def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015749
name: monosaccharide transmembrane transport
namespace: biological_process
alt_id: GO:1905950
def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw]
synonym: "monosaccharide transport" RELATED []
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015750
name: pentose transmembrane transport
namespace: biological_process
def: "The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai]
synonym: "pentose transport" RELATED []
is_a: GO:0015749 ! monosaccharide transmembrane transport

[Term]
id: GO:0015751
name: arabinose transmembrane transport
namespace: biological_process
def: "The process in which arabinose, a pentose monosaccharide that occurs in both D and L configurations, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl]
synonym: "arabinose transport" RELATED []
is_a: GO:0015750 ! pentose transmembrane transport

[Term]
id: GO:0015752
name: D-ribose transmembrane transport
namespace: biological_process
def: "The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai]
synonym: "D-ribose transport" RELATED []
is_a: GO:0015750 ! pentose transmembrane transport

[Term]
id: GO:0015753
name: D-xylose transmembrane transport
namespace: biological_process
def: "The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai]
synonym: "D-xylose transport" RELATED []
is_a: GO:0015750 ! pentose transmembrane transport

[Term]
id: GO:0015754
name: D-allose transmembrane transport
namespace: biological_process
def: "The process in which D-allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai]
synonym: "allose transmembrane transport" NARROW []
synonym: "allose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport

[Term]
id: GO:0015755
name: fructose transmembrane transport
namespace: biological_process
def: "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai]
synonym: "fructose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport

[Term]
id: GO:0015756
name: fucose transmembrane transport
namespace: biological_process
def: "The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai]
synonym: "fucose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport

[Term]
id: GO:0015757
name: galactose transmembrane transport
namespace: biological_process
def: "The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai]
synonym: "galactose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport

[Term]
id: GO:0015759
name: beta-glucoside transport
namespace: biological_process
def: "The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, ISBN:0198506732, PMID:3034860, PMID:6756954]
is_a: GO:0042946 ! glucoside transport

[Term]
id: GO:0015760
name: glucose-6-phosphate transport
namespace: biological_process
def: "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015712 ! hexose phosphate transport

[Term]
id: GO:0015761
name: mannose transmembrane transport
namespace: biological_process
def: "The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai]
synonym: "mannose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport

[Term]
id: GO:0015762
name: rhamnose transmembrane transport
namespace: biological_process
def: "The process in which rhamnose is transported across a lipid bilayer, from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai]
synonym: "rhamnose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport

[Term]
id: GO:0015763
name: N-acetylgalactosamine transport
namespace: biological_process
def: "The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai]
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015764
name: N-acetylglucosamine transport
namespace: biological_process
def: "The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015765
name: methylgalactoside transport
namespace: biological_process
def: "The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:curators]
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0015766
name: disaccharide transport
namespace: biological_process
def: "The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0015767
name: lactose transport
namespace: biological_process
def: "The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai]
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015768
name: maltose transport
namespace: biological_process
def: "The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai]
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015769
name: melibiose transport
namespace: biological_process
def: "The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai]
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015770
name: sucrose transport
namespace: biological_process
def: "The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai]
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015771
name: trehalose transport
namespace: biological_process
def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:ai, PMID:17606922, PMID:20035867]
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015772
name: oligosaccharide transport
namespace: biological_process
def: "The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015773
name: raffinose transport
namespace: biological_process
def: "The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:0015774
name: polysaccharide transport
namespace: biological_process
def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport
relationship: part_of GO:0033037 ! polysaccharide localization

[Term]
id: GO:0015775
name: beta-glucan transport
namespace: biological_process
def: "The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai]
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015776
name: capsular polysaccharide transport
namespace: biological_process
def: "The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]
synonym: "capsular-polysaccharide transport" EXACT []
synonym: "capsule polysaccharide transport" EXACT []
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015777
name: teichoic acid transport
namespace: biological_process
def: "The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai]
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015778
name: hexuronide transmembrane transport
namespace: biological_process
def: "The directed movement of hexuronide across a membrane. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai]
synonym: "hexuronide transport" BROAD []
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015779
name: glucuronoside transport
namespace: biological_process
def: "The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai]
synonym: "glucuronide transport" EXACT []
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0015780
name: nucleotide-sugar transmembrane transport
namespace: biological_process
def: "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
synonym: "nucleotide-sugar transport" RELATED []
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:0055085 ! transmembrane transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015782
name: CMP-N-acetylneuraminate transmembrane transport
namespace: biological_process
def: "The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "CMP-N-acetylneuraminate transport" RELATED []
synonym: "CMP-sialic acid transport" BROAD []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport

[Term]
id: GO:0015783
name: GDP-fucose transmembrane transport
namespace: biological_process
def: "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-fucose transport" RELATED []
is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport

[Term]
id: GO:0015786
name: UDP-glucose transmembrane transport
namespace: biological_process
def: "The process in which UDP-glucose is transported across a membrane." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport

[Term]
id: GO:0015787
name: UDP-glucuronic acid transmembrane transport
namespace: biological_process
def: "The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-glucuronic acid transport" RELATED []
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015789
name: UDP-N-acetylgalactosamine transmembrane transport
namespace: biological_process
def: "The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-N-acetylgalactosamine transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport

[Term]
id: GO:0015790
name: UDP-xylose transmembrane transport
namespace: biological_process
def: "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-xylose transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport

[Term]
id: GO:0015791
name: polyol transmembrane transport
namespace: biological_process
def: "The directed movement of polyols, any polyhydric alcohol, across a membrane." [GOC:ai]
subset: goslim_pir
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0015792
name: arabinitol transmembrane transport
namespace: biological_process
def: "The process in which arabitol is transported across a lipid bilayer, from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
synonym: "arabinitol transport" RELATED []
synonym: "arabitol transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015793
name: glycerol transmembrane transport
namespace: biological_process
def: "The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai]
synonym: "glycerol transport" BROAD []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015794
name: glycerol-3-phosphate transmembrane transport
namespace: biological_process
def: "The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai]
synonym: "glycerol-3-phosphate transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0055085 ! transmembrane transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015795
name: sorbitol transmembrane transport
namespace: biological_process
def: "The directed movement of sorbitol across a membrane. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732]
synonym: "glucitol transport" EXACT []
synonym: "sorbitol transport" BROAD []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015796
name: galactitol transmembrane transport
namespace: biological_process
def: "The directed movement of galactitol across a membrane. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai]
synonym: "galactitol transport" BROAD []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015797
name: mannitol transmembrane transport
namespace: biological_process
def: "The directed movement of mannitol across a membrane. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai]
synonym: "mannitol transport" BROAD []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015798
name: myo-inositol transport
namespace: biological_process
def: "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]
synonym: "vitamin Bh transport" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015799
name: propanediol transport
namespace: biological_process
def: "The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [PMID:24002752]
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015800
name: acidic amino acid transport
namespace: biological_process
def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015801
name: aromatic amino acid transport
namespace: biological_process
def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015802
name: basic amino acid transport
namespace: biological_process
def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015803
name: branched-chain amino acid transport
namespace: biological_process
alt_id: GO:1900755
def: "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf]
synonym: "branched-chain aliphatic amino acid transport" EXACT []
synonym: "branched-chain amino-acid anion transport" EXACT [GOC:jl]
synonym: "branched-chain amino-acid anions transport" RELATED [GOC:TermGenie]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015804
name: neutral amino acid transport
namespace: biological_process
def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015805
name: S-adenosyl-L-methionine transport
namespace: biological_process
def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "S-adenosyl methionine transport" EXACT []
synonym: "S-adenosylmethionine transport" EXACT []
synonym: "SAM transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015806
name: S-methylmethionine transport
namespace: biological_process
def: "The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015807
name: L-amino acid transport
namespace: biological_process
def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015808
name: L-alanine transport
namespace: biological_process
def: "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0032328 ! alanine transport

[Term]
id: GO:0015810
name: aspartate transmembrane transport
namespace: biological_process
def: "The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators, ISBN:0198506732]
synonym: "aspartate transport" BROAD []
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015811
name: L-cystine transport
namespace: biological_process
def: "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015812
name: gamma-aminobutyric acid transport
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'.
synonym: "4-aminobutanoate transport" EXACT []
synonym: "4-aminobutyrate transport" EXACT []
synonym: "GABA transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015813
name: L-glutamate transmembrane transport
namespace: biological_process
alt_id: GO:0089711
def: "The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]
synonym: "L-glutamate transport" BROAD []
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0051938 ! L-glutamate import
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0015814
name: p-aminobenzoyl-glutamate transport
namespace: biological_process
def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0042938 ! dipeptide transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015816
name: glycine transport
namespace: biological_process
def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015817
name: histidine transport
namespace: biological_process
def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-histidine transport" NARROW []
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015818
name: isoleucine transport
namespace: biological_process
def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-isoleucine transport" NARROW []
is_a: GO:0015803 ! branched-chain amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015819
name: lysine transport
namespace: biological_process
alt_id: GO:0034226
alt_id: GO:0061461
def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-lysine import" NARROW []
synonym: "L-lysine transport" RELATED []
synonym: "lysine import" NARROW []
synonym: "lysine uptake" NARROW []
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:1902022 ! L-lysine transport

[Term]
id: GO:0015820
name: L-leucine transport
namespace: biological_process
def: "The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "leucine transport" BROAD []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015803 ! branched-chain amino acid transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015821
name: methionine transport
namespace: biological_process
def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-methionine transport" NARROW []
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015695 ! organic cation transport

[Term]
id: GO:0015822
name: ornithine transport
namespace: biological_process
def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-ornithine transport" NARROW []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015823
name: phenylalanine transport
namespace: biological_process
def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-phenylalanine transport" NARROW []
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015824
name: proline transport
namespace: biological_process
def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-proline transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015825
name: L-serine transport
namespace: biological_process
alt_id: GO:0090479
def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-serine import" NARROW []
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0032329 ! serine transport

[Term]
id: GO:0015826
name: threonine transport
namespace: biological_process
def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-threonine transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015827
name: tryptophan transport
namespace: biological_process
def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-tryptophan transport" NARROW []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015828
name: tyrosine transport
namespace: biological_process
def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-tyrosine transport" NARROW []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015801 ! aromatic amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015829
name: valine transport
namespace: biological_process
def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "L-valine transport" NARROW []
is_a: GO:0015803 ! branched-chain amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015830
name: diaminopimelate transport
namespace: biological_process
def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901571 ! fatty acid derivative transport

[Term]
id: GO:0015832
name: obsolete holin
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "holin" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015833
name: peptide transport
namespace: biological_process
def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015834
name: peptidoglycan-associated peptide transport
namespace: biological_process
def: "The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732]
synonym: "murein peptide transport" EXACT []
synonym: "muropeptide transport" EXACT []
synonym: "peptidoglycan peptide transport" EXACT [GOC:mah]
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0015835
name: peptidoglycan transport
namespace: biological_process
def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
synonym: "murein transport" EXACT []
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015836
name: lipid-linked peptidoglycan transport
namespace: biological_process
def: "The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "lipid-linked murein transport" EXACT []
is_a: GO:0015835 ! peptidoglycan transport

[Term]
id: GO:0015837
name: amine transport
namespace: biological_process
def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
synonym: "amine/polyamine transport" RELATED []
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015838
name: amino-acid betaine transport
namespace: biological_process
def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "betaine transport" EXACT []
is_a: GO:0015697 ! quaternary ammonium group transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015839
name: cadaverine transport
namespace: biological_process
def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015840
name: urea transport
namespace: biological_process
def: "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2." [GOC:ai, ISBN:0198506732]
is_a: GO:0019755 ! one-carbon compound transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015841
name: chromaffin granule amine transport
namespace: biological_process
def: "The directed movement of amines into, out of or within chromaffin granules." [GOC:mah]
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015842
name: aminergic neurotransmitter loading into synaptic vesicle
namespace: biological_process
def: "The active transport of aminergic neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps." [GOC:ai]
is_a: GO:0015837 ! amine transport
is_a: GO:0098700 ! neurotransmitter loading into synaptic vesicle

[Term]
id: GO:0015843
name: methylammonium transport
namespace: biological_process
def: "The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015837 ! amine transport
is_a: GO:0019755 ! one-carbon compound transport

[Term]
id: GO:0015844
name: monoamine transport
namespace: biological_process
alt_id: GO:0015873
def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015846
name: polyamine transport
namespace: biological_process
def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015847
name: putrescine transport
namespace: biological_process
def: "The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0015848
name: spermidine transport
namespace: biological_process
def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0015849
name: organic acid transport
namespace: biological_process
def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0015850
name: organic hydroxy compound transport
namespace: biological_process
def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]
synonym: "organic alcohol transport" EXACT []
is_a: GO:0006810 ! transport

[Term]
id: GO:0015851
name: nucleobase transport
namespace: biological_process
def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
synonym: "nucleobase transmembrane transport" EXACT [GOC:mah]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015853
name: adenine transport
namespace: biological_process
def: "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
synonym: "adenine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006863 ! purine nucleobase transport

[Term]
id: GO:0015854
name: guanine transport
namespace: biological_process
def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0006863 ! purine nucleobase transport

[Term]
id: GO:0015855
name: pyrimidine nucleobase transport
namespace: biological_process
def: "The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "pyrimidine base transmembrane transport" EXACT [GOC:mah]
synonym: "pyrimidine base transport" EXACT [GOC:go_curators]
synonym: "pyrimidine transmembrane transport" RELATED [GOC:mah]
synonym: "pyrimidine transport" RELATED []
is_a: GO:0015851 ! nucleobase transport

[Term]
id: GO:0015856
name: cytosine transport
namespace: biological_process
def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
synonym: "cytosine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0015855 ! pyrimidine nucleobase transport

[Term]
id: GO:0015857
name: uracil transport
namespace: biological_process
def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015855 ! pyrimidine nucleobase transport

[Term]
id: GO:0015858
name: nucleoside transport
namespace: biological_process
def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015859
name: intracellular nucleoside transport
namespace: biological_process
def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai]
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0015860
name: purine nucleoside transmembrane transport
namespace: biological_process
alt_id: GO:0035427
def: "The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar." [GOC:ai, GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "purine nucleoside membrane transport" EXACT []
synonym: "purine nucleoside transport" BROAD [GOC:vw]
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901642 ! nucleoside transmembrane transport

[Term]
id: GO:0015861
name: cytidine transport
namespace: biological_process
def: "The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0015862
name: uridine transmembrane transport
namespace: biological_process
def: "The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015864 ! pyrimidine nucleoside transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
is_a: GO:1901642 ! nucleoside transmembrane transport

[Term]
id: GO:0015863
name: xanthosine transport
namespace: biological_process
def: "The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0015864
name: pyrimidine nucleoside transport
namespace: biological_process
def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0015865
name: purine nucleotide transport
namespace: biological_process
def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0015866
name: ADP transport
namespace: biological_process
def: "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0015867
name: ATP transport
namespace: biological_process
def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0015868
name: purine ribonucleotide transport
namespace: biological_process
def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0015865 ! purine nucleotide transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015869
name: protein-DNA complex transport
namespace: biological_process
def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "DNA-protein complex transport" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0015870
name: acetylcholine transport
namespace: biological_process
def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901374 ! acetate ester transport

[Term]
id: GO:0015871
name: choline transport
namespace: biological_process
def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015872
name: dopamine transport
namespace: biological_process
def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0015874
name: norepinephrine transport
namespace: biological_process
def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732]
synonym: "levarterenol transport" EXACT []
synonym: "noradrenaline transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0015875
name: obsolete vitamin or cofactor transport
namespace: biological_process
def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "vitamin or cofactor transport" EXACT []
is_obsolete: true
consider: GO:0051180

[Term]
id: GO:0015876
name: acetyl-CoA transport
namespace: biological_process
def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
is_a: GO:0015916 ! fatty-acyl-CoA transport

[Term]
id: GO:0015877
name: biopterin transport
namespace: biological_process
def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015878
name: biotin transport
namespace: biological_process
def: "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai]
synonym: "vitamin B7 transport" EXACT []
synonym: "vitamin H transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015879
name: carnitine transport
namespace: biological_process
def: "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai]
synonym: "vitamin Bt transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015838 ! amino-acid betaine transport

[Term]
id: GO:0015880
name: coenzyme A transport
namespace: biological_process
def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:0042886 ! amide transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015881
name: creatine transmembrane transport
namespace: biological_process
alt_id: GO:1902598
def: "The directed movement of creatine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "creatine transport" BROAD []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015882
name: L-ascorbic acid transmembrane transport
namespace: biological_process
def: "The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:ai]
synonym: "L-ascorbate transport" EXACT []
synonym: "L-ascorbic acid transport" RELATED []
synonym: "vitamin C transport" EXACT []
is_a: GO:0015749 ! monosaccharide transmembrane transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015883
name: FAD transport
namespace: biological_process
def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732]
synonym: "flavin adenine dinucleotide transport" EXACT []
synonym: "flavin-adenine dinucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015884
name: folic acid transport
namespace: biological_process
def: "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai]
synonym: "folate transport" EXACT []
synonym: "vitamin B9 transport" EXACT []
synonym: "vitamin M transport" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015885
name: 5-formyltetrahydrofolate transport
namespace: biological_process
def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015886
name: heme transport
namespace: biological_process
def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "haem transport" EXACT []
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901678 ! iron coordination entity transport

[Term]
id: GO:0015887
name: pantothenate transmembrane transport
namespace: biological_process
def: "The process in which pantothenate is transported across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "pantothenate membrane transport" EXACT []
synonym: "pantothenate transport" EXACT [GOC:mah]
synonym: "vitamin B5 transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0042886 ! amide transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015888
name: thiamine transport
namespace: biological_process
def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai]
synonym: "thiamin transport" EXACT []
synonym: "vitamin B1 transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015889
name: cobalamin transport
namespace: biological_process
def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "vitamin B12 transport" EXACT []
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015890
name: nicotinamide mononucleotide transport
namespace: biological_process
def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544]
synonym: "nicotinamide ribonucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015891
name: siderophore transport
namespace: biological_process
alt_id: GO:0015892
def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
synonym: "iron-siderochrome transport" NARROW []
synonym: "iron-siderophore transport" EXACT []
synonym: "siderochrome transport" NARROW []
synonym: "siderophore-iron transport" EXACT []
is_a: GO:1901678 ! iron coordination entity transport

[Term]
id: GO:0015894
name: obsolete acriflavine transport
namespace: biological_process
def: "OBSOLETE. The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [GOC:curators, PubChem_Compound:6842]
comment: This term is out of scope for GO.
synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0015895
name: alkane transport
namespace: biological_process
def: "The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015896
name: obsolete nalidixic acid transport
namespace: biological_process
def: "OBSOLETE. The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:0015897
name: obsolete organomercurial transport
namespace: biological_process
def: "OBSOLETE. The process in which an organomercurial compound is transported across a membrane. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0015898
name: obsolete amiloride transport
namespace: biological_process
def: "OBSOLETE. The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:0015899
name: aminotriazole transport
namespace: biological_process
def: "The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [GOC:curators]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015900
name: obsolete benomyl transport
namespace: biological_process
def: "OBSOLETE. The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [GOC:curators]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:0015901
name: cycloheximide transport
namespace: biological_process
def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015902
name: obsolete carbonyl cyanide m-chlorophenylhydrazone transport
namespace: biological_process
def: "OBSOLETE. The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [GOC:curators]
comment: This term is out of scope for GO.
synonym: "CCCP transport" EXACT []
is_obsolete: true

[Term]
id: GO:0015903
name: fluconazole transport
namespace: biological_process
def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015904
name: tetracycline transmembrane transport
namespace: biological_process
def: "The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators]
synonym: "tetracyclin transport" BROAD []
synonym: "tetracycline transport" BROAD []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0015905
name: bicyclomycin transmembrane transport
namespace: biological_process
def: "The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [PMID:20067529]
synonym: "bicyclomycin transport" BROAD []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015908
name: fatty acid transport
namespace: biological_process
def: "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai]
is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015909
name: long-chain fatty acid transport
namespace: biological_process
def: "The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ai]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0015910
name: long-chain fatty acid import into peroxisome
namespace: biological_process
def: "The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ai]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "peroxisomal long-chain fatty acid import" EXACT []
synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0015919 ! peroxisomal membrane transport
is_a: GO:0032365 ! intracellular lipid transport
is_a: GO:1902001 ! fatty acid transmembrane transport

[Term]
id: GO:0015911
name: long-chain fatty acid import across plasma membrane
namespace: biological_process
def: "The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ai]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "plasma membrane long-chain fatty acid transport" EXACT []
is_a: GO:0044539 ! long-chain fatty acid import into cell
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1902001 ! fatty acid transmembrane transport

[Term]
id: GO:0015912
name: short-chain fatty acid transport
namespace: biological_process
def: "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:ai]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0015913
name: short-chain fatty acid transmembrane transport
namespace: biological_process
def: "The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:ai]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "short-chain fatty acid import" RELATED []
synonym: "short-chain fatty acid uptake" EXACT []
is_a: GO:0015912 ! short-chain fatty acid transport
is_a: GO:1902001 ! fatty acid transmembrane transport

[Term]
id: GO:0015914
name: phospholipid transport
namespace: biological_process
def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]
is_a: GO:0006869 ! lipid transport
is_a: GO:0015748 ! organophosphate ester transport

[Term]
id: GO:0015915
name: obsolete fatty-acyl group transport
namespace: biological_process
def: "OBSOLETE. The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai]
comment: This term was obsoleted because it was created by error; individual groups in molecules are not transported.
synonym: "fatty acyl transport" EXACT []
is_obsolete: true

[Term]
id: GO:0015916
name: fatty-acyl-CoA transport
namespace: biological_process
def: "The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732]
synonym: "fatty acyl CoA transport" EXACT []
synonym: "fatty acyl coenzyme A transport" EXACT []
synonym: "fatty acyl-CoA transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:0042886 ! amide transport
is_a: GO:1901337 ! thioester transport

[Term]
id: GO:0015917
name: aminophospholipid transport
namespace: biological_process
def: "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai]
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015918
name: sterol transport
namespace: biological_process
def: "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
is_a: GO:0006869 ! lipid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015919
name: peroxisomal membrane transport
namespace: biological_process
def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai]
is_a: GO:0043574 ! peroxisomal transport

[Term]
id: GO:0015920
name: lipopolysaccharide transport
namespace: biological_process
alt_id: GO:0015921
def: "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai]
subset: goslim_pir
synonym: "lipopolysaccharide export" NARROW []
synonym: "LPS export" NARROW []
synonym: "LPS transport" EXACT []
is_a: GO:0006869 ! lipid transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015922
name: obsolete aspartate oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide." [GOC:curators]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
consider: GO:0008445
consider: GO:0008734

[Term]
id: GO:0015923
name: mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015924
name: mannosyl-oligosaccharide mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [GOC:ai]
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0015925
name: galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015926
name: glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015927
name: trehalase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai, PMID:31925485]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015928
name: fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015929
name: hexosaminidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015930
name: glutamate synthase activity
namespace: molecular_function
def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [GOC:curators]
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0015931
name: nucleobase-containing compound transport
namespace: biological_process
def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015932
name: nucleobase-containing compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015933
name: obsolete flavin-containing electron transporter
namespace: molecular_function
def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd]
comment: This term was made obsolete because it does not describe a molecular function.
synonym: "flavin-containing electron transporter" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015934
name: large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
synonym: "ribosomal large subunit" EXACT []
is_a: GO:0044391 ! ribosomal subunit

[Term]
id: GO:0015935
name: small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a ribosome." [GOC:mah]
subset: goslim_pir
synonym: "ribosomal small subunit" EXACT []
is_a: GO:0044391 ! ribosomal subunit

[Term]
id: GO:0015936
name: coenzyme A metabolic process
namespace: biological_process
alt_id: GO:0006763
def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
synonym: "CoA metabolism" EXACT []
synonym: "coenzyme A metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0015937
name: coenzyme A biosynthetic process
namespace: biological_process
alt_id: GO:0006764
def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
synonym: "CoA biosynthesis" EXACT []
synonym: "coenzyme A anabolism" EXACT []
synonym: "coenzyme A biosynthesis" EXACT []
synonym: "coenzyme A formation" EXACT []
synonym: "coenzyme A synthesis" EXACT []
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0015938
name: coenzyme A catabolic process
namespace: biological_process
alt_id: GO:0006765
def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
synonym: "CoA catabolism" EXACT []
synonym: "coenzyme A breakdown" EXACT []
synonym: "coenzyme A catabolism" EXACT []
synonym: "coenzyme A degradation" EXACT []
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0015939
name: pantothenate metabolic process
namespace: biological_process
alt_id: GO:0006770
def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
synonym: "pantothenate metabolism" EXACT []
synonym: "vitamin B5 metabolic process" EXACT []
synonym: "vitamin B5 metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0015940
name: pantothenate biosynthetic process
namespace: biological_process
alt_id: GO:0033317
alt_id: GO:0033318
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
synonym: "pantothenate anabolism" EXACT []
synonym: "pantothenate anabolism from 2-oxypantoyl lactone" NARROW []
synonym: "pantothenate anabolism from valine" NARROW []
synonym: "pantothenate biosynthesis" EXACT []
synonym: "pantothenate biosynthesis from 2-oxypantoyl lactone" NARROW []
synonym: "pantothenate biosynthesis from valine" NARROW []
synonym: "pantothenate biosynthetic process from 2-dehydropantolactone" NARROW []
synonym: "pantothenate biosynthetic process from 2-oxypantoyl lactone" NARROW []
synonym: "pantothenate biosynthetic process from valine" NARROW []
synonym: "pantothenate formation" EXACT []
synonym: "pantothenate formation from 2-oxypantoyl lactone" NARROW []
synonym: "pantothenate formation from valine" NARROW []
synonym: "pantothenate synthesis" EXACT []
synonym: "pantothenate synthesis from 2-oxypantoyl lactone" NARROW []
synonym: "pantothenate synthesis from valine" NARROW []
synonym: "vitamin B5 biosynthesis" EXACT []
synonym: "vitamin B5 biosynthetic process" EXACT []
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0015941
name: pantothenate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
synonym: "pantothenate breakdown" EXACT []
synonym: "pantothenate catabolism" EXACT []
synonym: "pantothenate degradation" EXACT []
synonym: "vitamin B5 catabolic process" EXACT []
synonym: "vitamin B5 catabolism" EXACT []
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0015942
name: formate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]
synonym: "formate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0015943
name: formate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]
synonym: "formate anabolism" EXACT []
synonym: "formate biosynthesis" EXACT []
synonym: "formate formation" EXACT []
synonym: "formate synthesis" EXACT []
synonym: "formic acid biosynthesis" EXACT []
synonym: "formic acid biosynthetic process" EXACT []
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0015944
name: formate oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which formate is converted to CO2." [MetaCyc:PWY-1881]
synonym: "formic acid oxidation" EXACT []
xref: MetaCyc:PWY-1881
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0015945
name: methanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732]
synonym: "methanol metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0015946
name: methanol oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M." [MetaCyc:CO2FORM-PWY]
xref: MetaCyc:CO2FORM-PWY
is_a: GO:0015945 ! methanol metabolic process

[Term]
id: GO:0015947
name: methane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732]
synonym: "methane metabolism" EXACT []
is_a: GO:0043446 ! alkane metabolic process

[Term]
id: GO:0015948
name: methanogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "methane biosynthesis" EXACT []
synonym: "methane biosynthetic process" EXACT []
xref: UM-BBD_pathwayID:meth
xref: Wikipedia:Methanogenesis
is_a: GO:0009061 ! anaerobic respiration
is_a: GO:0015947 ! methane metabolic process
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0043447 ! alkane biosynthetic process

[Term]
id: GO:0015949
name: nucleobase-containing small molecule interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: goslim_pir
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0015950
name: purine nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion

[Term]
id: GO:0015951
name: purine ribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0015950 ! purine nucleotide interconversion

[Term]
id: GO:0015952
name: purine deoxyribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0015950 ! purine nucleotide interconversion

[Term]
id: GO:0015953
name: pyrimidine nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion

[Term]
id: GO:0015954
name: pyrimidine ribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0015953 ! pyrimidine nucleotide interconversion

[Term]
id: GO:0015955
name: pyrimidine deoxyribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0015953 ! pyrimidine nucleotide interconversion

[Term]
id: GO:0015956
name: bis(5'-nucleosidyl) oligophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0015957
name: bis(5'-nucleosidyl) oligophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process

[Term]
id: GO:0015958
name: bis(5'-nucleosidyl) oligophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process

[Term]
id: GO:0015959
name: diadenosine polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
synonym: "diadenosine polyphosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0015960
name: diadenosine polyphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
synonym: "diadenosine polyphosphate anabolism" EXACT []
synonym: "diadenosine polyphosphate biosynthesis" EXACT []
synonym: "diadenosine polyphosphate formation" EXACT []
synonym: "diadenosine polyphosphate synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015961
name: diadenosine polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
synonym: "diadenosine polyphosphate breakdown" EXACT []
synonym: "diadenosine polyphosphate catabolism" EXACT []
synonym: "diadenosine polyphosphate degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015962
name: diadenosine triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
synonym: "diadenosine triphosphate metabolism" EXACT []
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015963
name: diadenosine triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
synonym: "diadenosine triphosphate anabolism" EXACT []
synonym: "diadenosine triphosphate biosynthesis" EXACT []
synonym: "diadenosine triphosphate formation" EXACT []
synonym: "diadenosine triphosphate synthesis" EXACT []
is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process
is_a: GO:0015962 ! diadenosine triphosphate metabolic process

[Term]
id: GO:0015964
name: diadenosine triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
synonym: "diadenosine triphosphate breakdown" EXACT []
synonym: "diadenosine triphosphate catabolism" EXACT []
synonym: "diadenosine triphosphate degradation" EXACT []
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:0015962 ! diadenosine triphosphate metabolic process

[Term]
id: GO:0015965
name: diadenosine tetraphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
synonym: "diadenosine tetraphosphate metabolism" EXACT []
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015966
name: diadenosine tetraphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
synonym: "diadenosine tetraphosphate anabolism" EXACT []
synonym: "diadenosine tetraphosphate biosynthesis" EXACT []
synonym: "diadenosine tetraphosphate formation" EXACT []
synonym: "diadenosine tetraphosphate synthesis" EXACT []
is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process
is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process

[Term]
id: GO:0015967
name: diadenosine tetraphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
synonym: "diadenosine tetraphosphate breakdown" EXACT []
synonym: "diadenosine tetraphosphate catabolism" EXACT []
synonym: "diadenosine tetraphosphate degradation" EXACT []
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process

[Term]
id: GO:0015968
name: stringent response
namespace: biological_process
def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471]
xref: Wikipedia:Stringent_response
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0015969
name: guanosine tetraphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT []
synonym: "guanosine tetraphosphate metabolism" EXACT []
xref: MetaCyc:PPGPPMET-PWY
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0015970
name: guanosine tetraphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT []
synonym: "guanosine tetraphosphate anabolism" EXACT []
synonym: "guanosine tetraphosphate biosynthesis" EXACT []
synonym: "guanosine tetraphosphate formation" EXACT []
synonym: "guanosine tetraphosphate synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0015969 ! guanosine tetraphosphate metabolic process
is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process

[Term]
id: GO:0015971
name: guanosine tetraphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT []
synonym: "guanosine tetraphosphate breakdown" EXACT []
synonym: "guanosine tetraphosphate catabolism" EXACT []
synonym: "guanosine tetraphosphate degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0015969 ! guanosine tetraphosphate metabolic process
is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process

[Term]
id: GO:0015972
name: guanosine pentaphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT []
synonym: "guanosine pentaphosphate metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0015973
name: guanosine pentaphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT []
synonym: "guanosine pentaphosphate anabolism" EXACT []
synonym: "guanosine pentaphosphate biosynthesis" EXACT []
synonym: "guanosine pentaphosphate formation" EXACT []
synonym: "guanosine pentaphosphate synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0015972 ! guanosine pentaphosphate metabolic process
is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process

[Term]
id: GO:0015974
name: guanosine pentaphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT []
synonym: "guanosine pentaphosphate breakdown" EXACT []
synonym: "guanosine pentaphosphate catabolism" EXACT []
synonym: "guanosine pentaphosphate degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0015972 ! guanosine pentaphosphate metabolic process
is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process

[Term]
id: GO:0015975
name: energy derivation by oxidation of reduced inorganic compounds
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]
synonym: "chemolithotrophie" EXACT []
synonym: "chemolithotrophy" EXACT []
synonym: "lithotrophy" EXACT [Wikipedia:Lithotrophy]
xref: Wikipedia:Lithotrophy
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0015976
name: carbon utilization
namespace: biological_process
alt_id: GO:0015978
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
subset: goslim_chembl
subset: goslim_pir
synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah]
synonym: "heterotrophy" EXACT []
xref: Wikipedia:Heterotroph
is_a: GO:0031667 ! response to nutrient levels

[Term]
id: GO:0015977
name: carbon fixation
namespace: biological_process
def: "A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, GOC:mah]
synonym: "autotrophic CO2 fixation" EXACT []
synonym: "autotrophic CO2 fixation pathway" EXACT []
synonym: "autotrophy" EXACT []
synonym: "carbon dioxide fixation" NARROW []
xref: Wikipedia:Carbon_fixation
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0015979
name: photosynthesis
namespace: biological_process
def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
xref: Wikipedia:Photosynthesis
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0015980
name: energy derivation by oxidation of organic compounds
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]
synonym: "chemoorganotrophy" EXACT []
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0015981
name: obsolete passive proton transport, down the electrochemical gradient
namespace: biological_process
def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363]
comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products.
synonym: "passive proton transport, down the electrochemical gradient" EXACT []
is_obsolete: true
consider: GO:1902600

[Term]
id: GO:0015982
name: obsolete antiport
namespace: biological_process
def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "antiport" EXACT []
is_obsolete: true
replaced_by: GO:0015297

[Term]
id: GO:0015983
name: obsolete symport
namespace: biological_process
def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "symport" EXACT []
is_obsolete: true
replaced_by: GO:0015293

[Term]
id: GO:0015984
name: obsolete uniport
namespace: biological_process
def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "uniport" EXACT []
is_obsolete: true
replaced_by: GO:0015292

[Term]
id: GO:0015985
name: energy coupled proton transport, down electrochemical gradient
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah]
is_a: GO:1902600 ! proton transmembrane transport

[Term]
id: GO:0015986
name: proton motive force-driven ATP synthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw]
synonym: "ATP synthesis coupled proton transport" RELATED []
synonym: "chemiosmosis" BROAD [GOC:rs]
is_a: GO:0006754 ! ATP biosynthetic process

[Term]
id: GO:0015987
name: GTP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363]
is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient

[Term]
id: GO:0015988
name: energy coupled proton transmembrane transport, against electrochemical gradient
namespace: biological_process
def: "The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah]
is_a: GO:1902600 ! proton transmembrane transport

[Term]
id: GO:0015989
name: obsolete light-driven proton transport
namespace: biological_process
def: "OBSOLETE. The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah]
comment: This term has been obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0015454

[Term]
id: GO:0015990
name: electron transport coupled proton transport
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah]
is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient

[Term]
id: GO:0015993
name: obsolete molecular hydrogen transport
namespace: biological_process
def: "OBSOLETE. The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
comment: The reason for obsoletion is that there molecular hydrogen (H2) diffuses passively through membranes (see https://www.researchgate.net/post/How_molecular_hydrogen_is_transported_through_the_cytoplasmic_membrane_of_Escherichia_coli).
is_obsolete: true

[Term]
id: GO:0015994
name: chlorophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]
synonym: "chlorophyll metabolism" EXACT []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process

[Term]
id: GO:0015995
name: chlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl]
synonym: "chlorophyll anabolism" EXACT []
synonym: "chlorophyll biosynthesis" EXACT []
synonym: "chlorophyll formation" EXACT []
synonym: "chlorophyll synthesis" EXACT []
xref: MetaCyc:CHLOROPHYLL-SYN
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0015994 ! chlorophyll metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0015996
name: chlorophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl]
synonym: "chlorophyll breakdown" EXACT []
synonym: "chlorophyll catabolism" EXACT []
synonym: "chlorophyll degradation" EXACT []
is_a: GO:0006787 ! porphyrin-containing compound catabolic process
is_a: GO:0015994 ! chlorophyll metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0015997
name: obsolete ubiquinone biosynthetic process monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it incorporates biological process information.
synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT []
synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT []
synonym: "ubiquinone anabolism monooxygenase activity" EXACT []
synonym: "ubiquinone biosynthetic process monooxygenase activity" EXACT []
synonym: "ubiquinone formation monooxygenase activity" EXACT []
synonym: "ubiquinone synthesis monooxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0016002
name: sulfite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [GOC:curators]
synonym: "assimilatory sulfite reductase activity" EXACT []
synonym: "assimilatory-type sulfite reductase activity" EXACT []
synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT []
synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT []
synonym: "sulphite reductase activity" EXACT []
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016004
name: phospholipase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai]
xref: Reactome:R-HSA-400023 "Gq alpha activates Phospholipase C beta"
is_a: GO:0060229 ! lipase activator activity

[Term]
id: GO:0016005
name: phospholipase A2 activator activity
namespace: molecular_function
def: "Binds to and increases the activity of the enzyme phospholipase A2." [GOC:ai]
is_a: GO:0016004 ! phospholipase activator activity

[Term]
id: GO:0016006
name: Nebenkern
namespace: cellular_component
def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma, PMID:25265054]
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016007
name: mitochondrial derivative
namespace: cellular_component
def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma]
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0016008
name: major mitochondrial derivative
namespace: cellular_component
def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504, PMID:24211517, PMID:30802236]
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016009
name: minor mitochondrial derivative
namespace: cellular_component
def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504, PMID:24211517, PMID:30802236]
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016010
name: dystrophin-associated glycoprotein complex
namespace: cellular_component
def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]
subset: goslim_pir
synonym: "DGC" EXACT []
synonym: "dystrophin glycoprotein complex" EXACT []
is_a: GO:0090665 ! glycoprotein complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0016011
name: dystroglycan complex
namespace: cellular_component
def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016012
name: sarcoglycan complex
namespace: cellular_component
def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
synonym: "sarcoglycan-sarcospan complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016011 ! dystroglycan complex

[Term]
id: GO:0016013
name: syntrophin complex
namespace: cellular_component
def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [PMID:23263165]
synonym: "nitric oxide synthase-dystrophin complex, skeletal muscle" RELATED [CORUM:416]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016014
name: dystrobrevin complex
namespace: cellular_component
def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016015
name: morphogen activity
namespace: molecular_function
def: "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators]
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0016016
name: obsolete short-wave-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "short-wave-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0016018
name: cyclosporin A binding
namespace: molecular_function
def: "Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb]
synonym: "cyclophilin" RELATED []
is_a: GO:0033218 ! amide binding

[Term]
id: GO:0016019
name: peptidoglycan immune receptor activity
namespace: molecular_function
def: "Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response." [PMID:14698226]
comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead.
synonym: "peptidoglycan receptor activity" BROAD []
synonym: "peptidoglycan recognition activity" NARROW []
is_a: GO:0038187 ! pattern recognition receptor activity

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
alt_id: GO:0016021
alt_id: GO:0098589
alt_id: GO:0098805
def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "integral component of membrane" NARROW []
synonym: "integral to membrane" NARROW []
synonym: "membrane region" NARROW []
synonym: "region of membrane" NARROW []
synonym: "transmembrane" RELATED [GOC:mah]
synonym: "whole membrane" NARROW []
xref: Wikipedia:Biological_membrane
xref: Wikipedia:Transmembrane_protein
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0016024
name: CDP-diacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [PMID:24533860]
synonym: "CDP-diacylglycerol anabolism" EXACT []
synonym: "CDP-diacylglycerol biosynthesis" EXACT []
synonym: "CDP-diacylglycerol formation" EXACT []
synonym: "CDP-diacylglycerol synthesis" EXACT []
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0016025
name: obsolete proteasome endopeptidase regulator
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "proteasome endopeptidase regulator" EXACT []
is_obsolete: true
consider: GO:0004175

[Term]
id: GO:0016026
name: obsolete proteasome endopeptidase core
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "proteasome endopeptidase core" EXACT []
is_obsolete: true
consider: GO:0004175

[Term]
id: GO:0016027
name: inaD signaling complex
namespace: cellular_component
def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
synonym: "inaD signalling complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016028 ! rhabdomere
relationship: part_of GO:0019897 ! extrinsic component of plasma membrane

[Term]
id: GO:0016028
name: rhabdomere
namespace: cellular_component
def: "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
subset: goslim_pir
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0016029
name: subrhabdomeral cisterna
namespace: cellular_component
def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774]
synonym: "SMC" RELATED []
synonym: "submicrovillar cisterna" EXACT [PMID:11707492]
is_a: GO:0098827 ! endoplasmic reticulum subcompartment
is_a: GO:0120082 ! smooth endoplasmic reticulum cisterna
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0016031
name: tRNA import into mitochondrion
namespace: biological_process
def: "The process in which a tRNA is transported from the cytosol into the mitochondrial matrix." [GOC:ma, PMID:10988073, PMID:11121736]
synonym: "cytoplasmic tRNA import into mitochondria" EXACT []
synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf]
synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT []
synonym: "cytoplasmic tRNA, mitochondrial import" EXACT []
synonym: "mitochondrial import of cytoplasmic tRNA" NARROW []
synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0035927 ! RNA import into mitochondrion
is_a: GO:0051031 ! tRNA transport

[Term]
id: GO:0016032
name: viral process
namespace: biological_process
alt_id: GO:0022415
def: "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah]
comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'.
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_virus
synonym: "viral infection" RELATED []
synonym: "virulence" RELATED []
synonym: "virus process" EXACT [GOC:bf, GOC:jl]
xref: Wikipedia:Viral_life_cycle
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016034
name: maleylacetoacetate isomerase activity
namespace: molecular_function
alt_id: GO:0018841
def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2]
synonym: "4-maleylacetoacetate cis-trans-isomerase activity" RELATED [EC:5.2.1.2]
synonym: "maleylacetoacetic isomerase activity" RELATED [EC:5.2.1.2]
synonym: "maleylacetone cis-trans-isomerase activity" RELATED [EC:5.2.1.2]
synonym: "maleylacetone isomerase activity" RELATED [EC:5.2.1.2]
xref: EC:5.2.1.2
xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN
xref: Reactome:R-HSA-71173 "GSTZ1 isomerizes 4-MAA"
xref: RHEA:14817
xref: UM-BBD_reactionID:r0106
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0016035
name: zeta DNA polymerase complex
namespace: cellular_component
def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464]
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0016036
name: cellular response to phosphate starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0016037
name: light absorption
namespace: biological_process
def: "The reception of a photon by a cell." [GOC:go_curators]
synonym: "absorption of light" EXACT []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0009583 ! detection of light stimulus

[Term]
id: GO:0016038
name: absorption of visible light
namespace: biological_process
def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0016037 ! light absorption

[Term]
id: GO:0016039
name: absorption of UV light
namespace: biological_process
def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0016037 ! light absorption

[Term]
id: GO:0016040
name: glutamate synthase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH." [EC:1.4.1.14, RHEA:13753]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" RELATED [EC:1.4.1.14]
synonym: "GOGAT activity" BROAD []
synonym: "L-glutamate synthase (NADH)" RELATED [EC:1.4.1.14]
synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14]
synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14]
synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" RELATED [EC:1.4.1.14]
synonym: "NADH-dependent glutamate synthase activity" RELATED [EC:1.4.1.14]
synonym: "NADH-glutamate synthase activity" RELATED [EC:1.4.1.14]
synonym: "NADH: GOGAT" RELATED [EC:1.4.1.14]
xref: EC:1.4.1.14
xref: KEGG_REACTION:R00093
xref: MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN
xref: RHEA:13753
is_a: GO:0015930 ! glutamate synthase activity

[Term]
id: GO:0016041
name: glutamate synthase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+." [EC:1.4.7.1]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "ferredoxin-dependent glutamate synthase activity" RELATED [EC:1.4.7.1]
synonym: "ferredoxin-glutamate synthase activity" RELATED [EC:1.4.7.1]
synonym: "glutamate synthase (ferredoxin-dependent)" RELATED [EC:1.4.7.1]
synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" RELATED [EC:1.4.7.1]
xref: EC:1.4.7.1
xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN
xref: RHEA:12128
is_a: GO:0015930 ! glutamate synthase activity
is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0016042
name: lipid catabolic process
namespace: biological_process
alt_id: GO:0006724
alt_id: GO:0044240
def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
synonym: "lipid breakdown" EXACT []
synonym: "lipid catabolism" EXACT []
synonym: "lipid degradation" EXACT []
synonym: "lipolysis" EXACT []
synonym: "multicellular organism lipid catabolic process" NARROW []
synonym: "multicellular organismal lipid catabolic process" NARROW []
xref: Wikipedia:Lipid_catabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0016043
name: cellular component organization
namespace: biological_process
alt_id: GO:0044235
alt_id: GO:0071842
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cell organisation" EXACT []
synonym: "cell organization and biogenesis" RELATED [GOC:mah]
synonym: "cellular component organisation at cellular level" EXACT [GOC:mah]
synonym: "cellular component organisation in other organism" EXACT [GOC:mah]
synonym: "cellular component organization at cellular level" EXACT []
synonym: "cellular component organization in other organism" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0016045
name: detection of bacterium
namespace: biological_process
alt_id: GO:0009598
alt_id: GO:0009681
def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of bacteria" EXACT []
synonym: "perception of bacteria" RELATED []
synonym: "perception of bacterium" RELATED []
is_a: GO:0009617 ! response to bacterium
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0016046
name: detection of fungus
namespace: biological_process
alt_id: GO:0009599
alt_id: GO:0016047
def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of fungi" EXACT []
synonym: "detection of parasitic fungi" NARROW []
synonym: "detection of parasitic fungus" NARROW []
synonym: "perception of fungi" RELATED []
synonym: "perception of fungus" RELATED []
synonym: "perception of parasitic fungi" NARROW []
synonym: "perception of parasitic fungus" RELATED []
is_a: GO:0009620 ! response to fungus
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0016048
name: detection of temperature stimulus
namespace: biological_process
def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of temperature" EXACT []
synonym: "detection of thermal stimulus" EXACT []
synonym: "perception of temperature" RELATED []
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0016049
name: cell growth
namespace: biological_process
alt_id: GO:0048591
def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_plant
synonym: "cell expansion" RELATED []
synonym: "cellular growth" EXACT []
synonym: "growth of cell" EXACT []
synonym: "metabolic process resulting in cell growth" RELATED []
synonym: "metabolism resulting in cell growth" RELATED []
synonym: "non-developmental cell growth" RELATED [GOC:mah]
synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0040007 ! growth

[Term]
id: GO:0016050
name: vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]
subset: goslim_pir
subset: goslim_yeast
synonym: "vesicle organisation" EXACT []
synonym: "vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0016051
name: carbohydrate biosynthetic process
namespace: biological_process
alt_id: GO:0006093
def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
synonym: "anabolic carbohydrate metabolic process" EXACT []
synonym: "anabolic carbohydrate metabolism" EXACT []
synonym: "carbohydrate anabolism" EXACT []
synonym: "carbohydrate biosynthesis" EXACT []
synonym: "carbohydrate formation" EXACT []
synonym: "carbohydrate synthesis" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0016052
name: carbohydrate catabolic process
namespace: biological_process
alt_id: GO:0006095
alt_id: GO:0044276
alt_id: GO:0044724
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
synonym: "carbohydrate breakdown" EXACT []
synonym: "carbohydrate catabolism" EXACT []
synonym: "carbohydrate degradation" EXACT []
synonym: "catabolic carbohydrate metabolic process" EXACT []
synonym: "catabolic carbohydrate metabolism" EXACT []
synonym: "multicellular organismal carbohydrate catabolic process" NARROW []
synonym: "single-organism carbohydrate catabolic process" RELATED []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0016053
name: organic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
synonym: "organic acid anabolism" EXACT []
synonym: "organic acid biosynthesis" EXACT []
synonym: "organic acid formation" EXACT []
synonym: "organic acid synthesis" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0016054
name: organic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
synonym: "organic acid breakdown" EXACT []
synonym: "organic acid catabolism" EXACT []
synonym: "organic acid degradation" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0016055
name: Wnt signaling pathway
namespace: biological_process
alt_id: GO:0007222
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]
synonym: "frizzled signaling pathway" EXACT []
synonym: "frizzled signalling pathway" EXACT []
synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wnt receptor signaling pathway" EXACT [GOC:signaling]
synonym: "Wnt receptor signalling pathway" EXACT []
synonym: "Wnt-activated signaling pathway" RELATED []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0016056
name: G protein-coupled opsin signaling pathway
namespace: biological_process
alt_id: GO:0009586
def: "A G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and ending with the light signal being trasmitted through the synapses. The signal can be transmitted via different Galpha subunits types: Go, Gs, Gq, and Gt." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb, PMID:19720651, PMID:36272560]
synonym: "G protein-mediated opsin signaling pathway" EXACT []
synonym: "rhodopsin mediated phototransduction" EXACT [GOC:bf]
synonym: "rhodopsin mediated signaling pathway" BROAD []
synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "rhodopsin signaling" EXACT [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0007602 ! phototransduction
is_a: GO:0071482 ! cellular response to light stimulus
relationship: part_of GO:0007603 ! phototransduction, visible light

[Term]
id: GO:0016057
name: regulation of membrane potential in photoreceptor cell
namespace: biological_process
def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0016058
name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling
namespace: biological_process
def: "Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "maintenance of rhodopsin mediated signaling" RELATED []
synonym: "maintenance of rhodopsin mediated signalling" EXACT []
is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell

[Term]
id: GO:0016059
name: negative regulation of opsin-mediated signaling pathway
namespace: biological_process
def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831]
synonym: "deactivation of opsin mediated signaling" NARROW []
synonym: "deactivation of rhodopsin mediated signalling" NARROW []
synonym: "negative regulation of rhodopsin-mediated signaling pathway" NARROW []
synonym: "rod response recovery" BROAD [GOC:bf]
is_a: GO:0022400 ! regulation of opsin-mediated signaling pathway
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
relationship: negatively_regulates GO:0016056 ! G protein-coupled opsin signaling pathway

[Term]
id: GO:0016060
name: negative regulation of phospholipase C-activating phototransduction signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating phototransduction signaling pathway. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, PMID:8316831]
synonym: "metarhodopsin inactivation" NARROW []
xref: Wikipedia:Visual_phototransduction
is_a: GO:0016059 ! negative regulation of opsin-mediated signaling pathway
is_a: GO:1900737 ! negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
relationship: negatively_regulates GO:0030265 ! phospholipase C-activating opsin-mediated signaling pathway

[Term]
id: GO:0016061
name: regulation of light-activated channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity

[Term]
id: GO:0016062
name: obsolete adaptation of rhodopsin mediated signaling
namespace: biological_process
def: "OBSOLETE. The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207]
comment: This term was obsoleted because it is not mediated by a protein, it's a property of the receptor and of the pathway.
synonym: "adaptation of rhodopsin mediated signalling" EXACT []
is_obsolete: true

[Term]
id: GO:0016063
name: rhodopsin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
synonym: "rhodopsin anabolism" EXACT []
synonym: "rhodopsin biosynthesis" EXACT []
synonym: "rhodopsin formation" EXACT []
synonym: "rhodopsin synthesis" EXACT []
is_a: GO:0006726 ! eye pigment biosynthetic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0046154 ! rhodopsin metabolic process

[Term]
id: GO:0016064
name: immunoglobulin mediated immune response
namespace: biological_process
def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "antibody-mediated immune response" EXACT []
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0016065
name: obsolete humoral defense mechanism (sensu Protostomia)
namespace: biological_process
def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jid]
comment: This term was made obsolete because antibodies are not found in the taxon Protostomia.
synonym: "humoral defence mechanism (sensu Protostomia)" EXACT []
synonym: "humoral defense mechanism (sensu Protostomia)" EXACT []
is_obsolete: true

[Term]
id: GO:0016068
name: type I hypersensitivity
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.
synonym: "immediate hypersensitivity response" EXACT []
xref: Wikipedia:Type_I_hypersensitivity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
synonym: "RNA metabolism" EXACT []
is_a: GO:0090304 ! nucleic acid metabolic process

[Term]
id: GO:0016071
name: mRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "mRNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0016072
name: rRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]
subset: goslim_drosophila
synonym: "rRNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0016073
name: snRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
synonym: "snRNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0016074
name: sno(s)RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc]
subset: goslim_drosophila
subset: goslim_pombe
synonym: "box C/D sRNA metabolic process" NARROW []
synonym: "snoRNA metabolism" NARROW []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0016075
name: rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]
synonym: "rRNA breakdown" EXACT []
synonym: "rRNA catabolism" EXACT []
synonym: "rRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0016072 ! rRNA metabolic process

[Term]
id: GO:0016076
name: snRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732]
synonym: "snRNA breakdown" EXACT []
synonym: "snRNA catabolism" EXACT []
synonym: "snRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0016073 ! snRNA metabolic process

[Term]
id: GO:0016077
name: sno(s)RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [GOC:krc, ISBN:0198506732]
synonym: "sno(s)RNA breakdown" EXACT []
synonym: "sno(s)RNA catabolism" EXACT []
synonym: "sno(s)RNA degradation" EXACT []
synonym: "snoRNA catabolic process" NARROW []
synonym: "sRNA catabolic process" NARROW []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:0016078
name: tRNA decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai]
synonym: "tRNA breakdown" EXACT []
synonym: "tRNA catabolic process" EXACT []
synonym: "tRNA catabolism" EXACT []
synonym: "tRNA degradation" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0016079
name: synaptic vesicle exocytosis
namespace: biological_process
def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
subset: goslim_synapse
is_a: GO:0045055 ! regulated exocytosis
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse
is_a: GO:0099643 ! signal release from synapse
relationship: part_of GO:0007269 ! neurotransmitter secretion
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0016080
name: synaptic vesicle targeting
namespace: biological_process
def: "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah]
is_a: GO:0006903 ! vesicle targeting
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016081
name: synaptic vesicle docking
namespace: biological_process
def: "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process." [PMID:15217342]
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015).
subset: goslim_synapse
synonym: "synaptic vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb]
synonym: "synaptic vesicle docking involved in exocytosis" EXACT []
is_a: GO:0006904 ! vesicle docking involved in exocytosis
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016082
name: synaptic vesicle priming
namespace: biological_process
def: "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342, PMID:23060190]
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)
subset: goslim_synapse
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016083
name: obsolete synaptic vesicle fusion
namespace: biological_process
def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle fusion" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016084
name: myostimulatory hormone activity
namespace: molecular_function
def: "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction." [GOC:mah, PMID:12204246]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016085
name: myoinhibitory hormone activity
namespace: molecular_function
def: "The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction." [GOC:mah, PMID:8902848]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016086
name: obsolete allatostatin
namespace: molecular_function
def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, PMID:10891383]
comment: This term was made obsolete because it refers to a gene product.
synonym: "allatostatin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0045968

[Term]
id: GO:0016087
name: ecdysiostatic hormone activity
namespace: molecular_function
def: "The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion." [DOI:10.1002/(SICI)1520-6327(1997)35\:1, GOC:mah]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0016088
name: obsolete insulin
namespace: molecular_function
def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "insulin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0045722
consider: GO:0045727
consider: GO:0045935
consider: GO:0046326
consider: GO:0046889

[Term]
id: GO:0016090
name: prenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684]
synonym: "prenol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0016091
name: prenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators]
synonym: "prenol anabolism" EXACT []
synonym: "prenol biosynthesis" EXACT []
synonym: "prenol formation" EXACT []
synonym: "prenol synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0016090 ! prenol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process

[Term]
id: GO:0016092
name: prenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators]
synonym: "prenol breakdown" EXACT []
synonym: "prenol catabolism" EXACT []
synonym: "prenol degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0016090 ! prenol metabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0016093
name: polyprenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [PMID:11108713]
synonym: "polyprenol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0016094
name: polyprenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, PMID:11108713]
synonym: "polyprenol anabolism" EXACT []
synonym: "polyprenol biosynthesis" EXACT []
synonym: "polyprenol formation" EXACT []
synonym: "polyprenol synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0016095
name: polyprenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, Wikipedia:Polyprenol]
synonym: "polyprenol breakdown" EXACT []
synonym: "polyprenol catabolism" EXACT []
synonym: "polyprenol degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0016098
name: monoterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [ISBN:0198547684]
synonym: "monoterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016099
name: monoterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [GOC:go_curators]
synonym: "monoterpenoid anabolism" EXACT []
synonym: "monoterpenoid biosynthesis" EXACT []
synonym: "monoterpenoid formation" EXACT []
synonym: "monoterpenoid synthesis" EXACT []
xref: MetaCyc:PWY-3041
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016100
name: monoterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [GOC:go_curators]
synonym: "monoterpenoid breakdown" EXACT []
synonym: "monoterpenoid catabolism" EXACT []
synonym: "monoterpenoid degradation" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016101
name: diterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684]
synonym: "diterpene metabolic process" NARROW []
synonym: "diterpene metabolism" NARROW []
synonym: "diterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016102
name: diterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684]
synonym: "diterpene biosynthesis" NARROW []
synonym: "diterpene biosynthetic process" NARROW []
synonym: "diterpenoid anabolism" EXACT []
synonym: "diterpenoid biosynthesis" EXACT []
synonym: "diterpenoid formation" EXACT []
synonym: "diterpenoid synthesis" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016103
name: diterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684]
synonym: "diterpene catabolic process" NARROW []
synonym: "diterpene catabolism" NARROW []
synonym: "diterpenoid breakdown" EXACT []
synonym: "diterpenoid catabolism" EXACT []
synonym: "diterpenoid degradation" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016104
name: triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators]
synonym: "triterpene biosynthesis" NARROW []
synonym: "triterpene biosynthetic process" NARROW []
synonym: "triterpenoid anabolism" EXACT []
synonym: "triterpenoid biosynthesis" EXACT []
synonym: "triterpenoid formation" EXACT []
synonym: "triterpenoid synthesis" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016105
name: triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators]
synonym: "triterpene catabolic process" NARROW []
synonym: "triterpene catabolism" NARROW []
synonym: "triterpenoid breakdown" EXACT []
synonym: "triterpenoid catabolism" EXACT []
synonym: "triterpenoid degradation" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016106
name: sesquiterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]
synonym: "sesquiterpenoid anabolism" EXACT []
synonym: "sesquiterpenoid biosynthesis" EXACT []
synonym: "sesquiterpenoid formation" EXACT []
synonym: "sesquiterpenoid synthesis" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016107
name: sesquiterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]
synonym: "sesquiterpenoid breakdown" EXACT []
synonym: "sesquiterpenoid catabolism" EXACT []
synonym: "sesquiterpenoid degradation" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016108
name: tetraterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684]
synonym: "tetraterpene metabolic process" NARROW []
synonym: "tetraterpene metabolism" NARROW []
synonym: "tetraterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016109
name: tetraterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]
synonym: "tetraterpene biosynthesis" NARROW []
synonym: "tetraterpene biosynthetic process" NARROW []
synonym: "tetraterpenoid anabolism" EXACT []
synonym: "tetraterpenoid biosynthesis" EXACT []
synonym: "tetraterpenoid formation" EXACT []
synonym: "tetraterpenoid synthesis" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016110
name: tetraterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]
synonym: "tetraterpene catabolic process" NARROW []
synonym: "tetraterpene catabolism" NARROW []
synonym: "tetraterpenoid breakdown" EXACT []
synonym: "tetraterpenoid catabolism" EXACT []
synonym: "tetraterpenoid degradation" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016111
name: polyterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684]
synonym: "polyterpene metabolic process" NARROW []
synonym: "polyterpene metabolism" NARROW []
synonym: "polyterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016112
name: polyterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]
synonym: "polyterpene biosynthesis" NARROW []
synonym: "polyterpene biosynthetic process" NARROW []
synonym: "polyterpenoid anabolism" EXACT []
synonym: "polyterpenoid biosynthesis" EXACT []
synonym: "polyterpenoid formation" EXACT []
synonym: "polyterpenoid synthesis" EXACT []
is_a: GO:0016111 ! polyterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016113
name: polyterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]
synonym: "polyterpene catabolic process" NARROW []
synonym: "polyterpene catabolism" NARROW []
synonym: "polyterpenoid breakdown" EXACT []
synonym: "polyterpenoid catabolism" EXACT []
synonym: "polyterpenoid degradation" EXACT []
is_a: GO:0016111 ! polyterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016114
name: terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]
synonym: "terpenoid anabolism" EXACT []
synonym: "terpenoid biosynthesis" EXACT []
synonym: "terpenoid formation" EXACT []
synonym: "terpenoid synthesis" EXACT []
xref: Wikipedia:Terpenoid
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:0016115
name: terpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]
synonym: "terpenoid breakdown" EXACT []
synonym: "terpenoid catabolism" EXACT []
synonym: "terpenoid degradation" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0008300 ! isoprenoid catabolic process

[Term]
id: GO:0016116
name: carotenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684]
synonym: "carotenoid metabolism" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process

[Term]
id: GO:0016117
name: carotenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
synonym: "carotenoid anabolism" EXACT []
synonym: "carotenoid biosynthesis" EXACT []
synonym: "carotenoid formation" EXACT []
synonym: "carotenoid synthesis" EXACT []
xref: MetaCyc:CAROTENOID-PWY
is_a: GO:0016109 ! tetraterpenoid biosynthetic process
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0016118
name: carotenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
synonym: "carotenoid breakdown" EXACT []
synonym: "carotenoid catabolism" EXACT []
synonym: "carotenoid degradation" EXACT []
is_a: GO:0016110 ! tetraterpenoid catabolic process
is_a: GO:0016116 ! carotenoid metabolic process

[Term]
id: GO:0016119
name: carotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684]
synonym: "carotene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0016120
name: carotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators]
synonym: "carotene anabolism" EXACT []
synonym: "carotene biosynthesis" EXACT []
synonym: "carotene formation" EXACT []
synonym: "carotene synthesis" EXACT []
is_a: GO:0016119 ! carotene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0016121
name: carotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators]
synonym: "carotene breakdown" EXACT []
synonym: "carotene catabolism" EXACT []
synonym: "carotene degradation" EXACT []
is_a: GO:0016119 ! carotene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0016122
name: xanthophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684]
synonym: "xanthophyll metabolism" EXACT []
is_a: GO:0016116 ! carotenoid metabolic process

[Term]
id: GO:0016123
name: xanthophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]
synonym: "xanthophyll anabolism" EXACT []
synonym: "xanthophyll biosynthesis" EXACT []
synonym: "xanthophyll formation" EXACT []
synonym: "xanthophyll synthesis" EXACT []
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0016124
name: xanthophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]
synonym: "xanthophyll breakdown" EXACT []
synonym: "xanthophyll catabolism" EXACT []
synonym: "xanthophyll degradation" EXACT []
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0016125
name: sterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]
synonym: "sterol metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0016126
name: sterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]
synonym: "sterol anabolism" EXACT []
synonym: "sterol biosynthesis" EXACT []
synonym: "sterol formation" EXACT []
synonym: "sterol synthesis" EXACT []
xref: MetaCyc:PWY-2541
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0016127
name: sterol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]
synonym: "sterol breakdown" EXACT []
synonym: "sterol catabolism" EXACT []
synonym: "sterol degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0016128
name: phytosteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684]
synonym: "phytosteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0016129
name: phytosteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309]
synonym: "phytosteroid anabolism" EXACT []
synonym: "phytosteroid biosynthesis" EXACT []
synonym: "phytosteroid formation" EXACT []
synonym: "phytosteroid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0016130
name: phytosteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah]
synonym: "phytosteroid breakdown" EXACT []
synonym: "phytosteroid catabolism" EXACT []
synonym: "phytosteroid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0016131
name: brassinosteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
synonym: "brassinosteroid metabolism" EXACT []
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0016132
name: brassinosteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
synonym: "brassinosteroid anabolism" EXACT []
synonym: "brassinosteroid biosynthesis" EXACT []
synonym: "brassinosteroid formation" EXACT []
synonym: "brassinosteroid synthesis" EXACT []
is_a: GO:0016129 ! phytosteroid biosynthetic process
is_a: GO:0016131 ! brassinosteroid metabolic process

[Term]
id: GO:0016133
name: brassinosteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
synonym: "brassinosteroid breakdown" EXACT []
synonym: "brassinosteroid catabolism" EXACT []
synonym: "brassinosteroid degradation" EXACT []
is_a: GO:0016130 ! phytosteroid catabolic process
is_a: GO:0016131 ! brassinosteroid metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0016134
name: saponin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684]
synonym: "saponin metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0016135
name: saponin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]
synonym: "saponin anabolism" EXACT []
synonym: "saponin biosynthesis" EXACT []
synonym: "saponin formation" EXACT []
synonym: "saponin synthesis" EXACT []
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process

[Term]
id: GO:0016136
name: saponin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]
synonym: "saponin breakdown" EXACT []
synonym: "saponin catabolism" EXACT []
synonym: "saponin degradation" EXACT []
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:0016139 ! glycoside catabolic process

[Term]
id: GO:0016137
name: glycoside metabolic process
namespace: biological_process
alt_id: GO:0016140
def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684]
synonym: "glycoside metabolism" EXACT []
synonym: "O-glycoside metabolic process" EXACT []
synonym: "O-glycoside metabolism" EXACT []
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0016138
name: glycoside biosynthetic process
namespace: biological_process
alt_id: GO:0016141
def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
synonym: "glycoside anabolism" EXACT []
synonym: "glycoside biosynthesis" EXACT []
synonym: "glycoside formation" EXACT []
synonym: "glycoside synthesis" EXACT []
synonym: "O-glycoside anabolism" EXACT []
synonym: "O-glycoside biosynthesis" EXACT []
synonym: "O-glycoside biosynthetic process" EXACT []
synonym: "O-glycoside formation" EXACT []
synonym: "O-glycoside synthesis" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0016139
name: glycoside catabolic process
namespace: biological_process
alt_id: GO:0016142
def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
synonym: "glycoside breakdown" EXACT []
synonym: "glycoside catabolism" EXACT []
synonym: "glycoside degradation" EXACT []
synonym: "O-glycoside breakdown" EXACT []
synonym: "O-glycoside catabolic process" EXACT []
synonym: "O-glycoside catabolism" EXACT []
synonym: "O-glycoside degradation" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:1901658 ! glycosyl compound catabolic process

[Term]
id: GO:0016143
name: S-glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]
synonym: "S-glycoside metabolism" EXACT []
synonym: "thioglycoside metabolic process" EXACT []
synonym: "thioglycoside metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0016144
name: S-glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]
synonym: "S-glycoside anabolism" EXACT []
synonym: "S-glycoside biosynthesis" EXACT []
synonym: "S-glycoside formation" EXACT []
synonym: "S-glycoside synthesis" EXACT []
synonym: "thioglycoside biosynthesis" EXACT []
synonym: "thioglycoside biosynthetic process" EXACT []
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0016145
name: S-glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]
synonym: "S-glycoside breakdown" EXACT []
synonym: "S-glycoside catabolism" EXACT []
synonym: "S-glycoside degradation" EXACT []
synonym: "thioglycoside catabolic process" EXACT []
synonym: "thioglycoside catabolism" EXACT []
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901658 ! glycosyl compound catabolic process

[Term]
id: GO:0016146
name: obsolete protein-synthesizing GTPase activity, initiation
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
synonym: "protein-synthesizing GTPase activity, initiation" EXACT []
is_obsolete: true
consider: GO:0003743
consider: GO:0003924
consider: GO:0006412
consider: GO:0006413

[Term]
id: GO:0016147
name: obsolete protein-synthesizing GTPase activity, elongation
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
synonym: "protein-synthesizing GTPase activity, elongation" EXACT []
is_obsolete: true
consider: GO:0003746
consider: GO:0003924
consider: GO:0006412
consider: GO:0006414

[Term]
id: GO:0016148
name: obsolete protein-synthesizing GTPase activity, termination
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
synonym: "protein-synthesizing GTPase activity, termination" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0006412
consider: GO:0006415
consider: GO:0008079

[Term]
id: GO:0016149
name: translation release factor activity, codon specific
namespace: molecular_function
def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]
is_a: GO:0003747 ! translation release factor activity

[Term]
id: GO:0016150
name: translation release factor activity, codon nonspecific
namespace: molecular_function
def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684]
is_a: GO:0003747 ! translation release factor activity

[Term]
id: GO:0016151
name: nickel cation binding
namespace: molecular_function
def: "Binding to a nickel (Ni) cation." [GOC:ai]
synonym: "Ni binding" EXACT []
synonym: "nickel binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0016152
name: mercury (II) reductase (NADP+) activity
namespace: molecular_function
alt_id: GO:0018692
def: "Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH." [RHEA:23856]
synonym: "Hg:NADP+ oxidoreductase activity" RELATED [EC:1.16.1.1]
synonym: "mer A" RELATED [EC:1.16.1.1]
synonym: "mercurate(II) reductase activity" RELATED [EC:1.16.1.1]
synonym: "mercuric ion reductase activity" RELATED [EC:1.16.1.1]
synonym: "mercuric reductase activity" RELATED [EC:1.16.1.1]
synonym: "mercury reductase activity" RELATED [EC:1.16.1.1]
synonym: "mercury(II) reductase activity" RELATED [EC:1.16.1.1]
synonym: "reduced NADP:mercuric ion oxidoreductase activity" RELATED [EC:1.16.1.1]
xref: EC:1.16.1.1
xref: KEGG_REACTION:R02807
xref: MetaCyc:MERCURY-II-REDUCTASE-RXN
xref: RHEA:23856
xref: UM-BBD_reactionID:r0406
is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[Term]
id: GO:0016153
name: urocanate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O." [EC:4.2.1.49, RHEA:13101]
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" RELATED [EC:4.2.1.49]
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" RELATED [EC:4.2.1.49]
synonym: "imidazolonepropionate hydrolase activity" RELATED [EC:4.2.1.49]
synonym: "urocanase activity" RELATED [EC:4.2.1.49]
xref: EC:4.2.1.49
xref: KEGG_REACTION:R02914
xref: MetaCyc:UROCANATE-HYDRATASE-RXN
xref: Reactome:R-HSA-70903 "urocanate + H2O => 4-imidazolone-5-propionate"
xref: RHEA:13101
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0016154
name: pyrimidine-nucleoside phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2]
synonym: "Py-NPase activity" RELATED [EC:2.4.2.2]
synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.2]
xref: EC:2.4.2.2
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0016155
name: formyltetrahydrofolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH." [EC:1.5.1.6, RHEA:10180]
synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" RELATED [EC:1.5.1.6]
synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" RELATED [EC:1.5.1.6]
synonym: "10-formyl-H4folate dehydrogenase activity" RELATED [EC:1.5.1.6]
synonym: "10-formyltetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.6]
synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.6]
synonym: "N10-formyltetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.6]
xref: EC:1.5.1.6
xref: KEGG_REACTION:R00941
xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN
xref: RHEA:10180
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016156
name: fumarate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + succinate = fumarate + H+ + NADH." [RHEA:18281]
synonym: "NADH-dependent fumarate reductase activity" RELATED [EC:1.3.1.6]
xref: EC:1.3.1.6
xref: KEGG_REACTION:R00402
xref: MetaCyc:FUMARATE-REDUCTASE-NADH-RXN
xref: RHEA:18281
is_a: GO:0000104 ! succinate dehydrogenase activity
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016157
name: sucrose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H+ + sucrose. The phosphate acceptor can be UDP or ADP." [RHEA:16241]
synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.13]
synonym: "sucrose synthetase activity" RELATED [EC:2.4.1.13]
synonym: "sucrose-UDP glucosyltransferase activity" RELATED [EC:2.4.1.13]
synonym: "sucrose-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.13]
synonym: "UDP-glucose-fructose glucosyltransferase activity" RELATED [EC:2.4.1.13]
synonym: "UDPglucose-fructose glucosyltransferase activity" RELATED [EC:2.4.1.13]
synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" RELATED [EC:2.4.1.13]
xref: EC:2.4.1.13
xref: MetaCyc:SUCROSE-SYNTHASE-RXN
xref: RHEA:16241
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016158
name: 3-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8]
synonym: "1-phytase activity" RELATED [EC:3.1.3.8]
synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.8]
synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT []
synonym: "phytase activity" BROAD []
synonym: "phytate 1-phosphatase activity" RELATED [EC:3.1.3.8]
synonym: "phytate 3-phosphatase activity" EXACT []
xref: EC:3.1.3.8
xref: MetaCyc:RXN0-1001
xref: RHEA:16989
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0016159
name: muconolactone delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate." [RHEA:12348]
synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" RELATED [EC:5.3.3.4]
synonym: "muconolactone D-isomerase activity" EXACT []
synonym: "muconolactone isomerase activity" RELATED [EC:5.3.3.4]
xref: EC:5.3.3.4
xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN
xref: RHEA:12348
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0016160
name: amylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016161
name: beta-amylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [PMID:18390594]
synonym: "4-alpha-D-glucan maltohydrolase activity" RELATED [EC:3.2.1.2]
synonym: "beta amylase activity" RELATED []
synonym: "glycogenase activity" BROAD [EC:3.2.1.2]
synonym: "saccharogen amylase activity" RELATED [EC:3.2.1.2]
xref: EC:3.2.1.2
xref: MetaCyc:RXN-1827
is_a: GO:0016160 ! amylase activity

[Term]
id: GO:0016162
name: cellulose 1,4-beta-cellobiosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
synonym: "1,4-beta-cellobiohydrolase activity" RELATED [EC:3.2.1.91]
synonym: "1,4-beta-D-glucan cellobiohydrolase activity" RELATED [EC:3.2.1.91]
synonym: "1,4-beta-glucan cellobiosidase activity" RELATED [EC:3.2.1.91]
synonym: "avicelase activity" BROAD [EC:3.2.1.91]
synonym: "beta-1,4-glucan cellobiohydrolase activity" RELATED [EC:3.2.1.91]
synonym: "beta-1,4-glucan cellobiosylhydrolase activity" RELATED [EC:3.2.1.91]
synonym: "C1 cellulase activity" RELATED [EC:3.2.1.91]
synonym: "CBH 1" RELATED [EC:3.2.1.91]
synonym: "cellobiohydrolase activity" RELATED [EC:3.2.1.91]
synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91]
synonym: "cellobiosidase activity" RELATED [EC:3.2.1.91]
synonym: "exo-1,4-beta-D-glucanase activity" RELATED [EC:3.2.1.91]
synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" RELATED [EC:3.2.1.91]
synonym: "exo-cellobiohydrolase activity" RELATED [EC:3.2.1.91]
synonym: "exocellobiohydrolase activity" RELATED [EC:3.2.1.91]
synonym: "exoglucanase activity" RELATED [EC:3.2.1.91]
xref: EC:3.2.1.91
xref: MetaCyc:3.2.1.91-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016163
name: nitrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H+ + H2 + 2 NH4+ + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate." [PMID:15382920, RHEA:21448]
synonym: "iron-iron nitrogenase activity" NARROW []
synonym: "molybdenum-iron nitrogenase activity" NARROW []
synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" RELATED [EC:1.18.6.1]
synonym: "vanadium-iron nitrogenase activity" NARROW []
xref: EC:1.18.6.1
xref: MetaCyc:NITROGENASE-RXN
xref: RHEA:21448
xref: UM-BBD_reactionID:r1810
is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor

[Term]
id: GO:0016164
name: obsolete Mo-molybdopterin oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the differentia from the parent is a gene product feature (specifically, the presence of a molybdopterin cofactor in the protein). It has also never been defined.
synonym: "Mo-molybdopterin oxidoreductase activity" EXACT []
synonym: "molybdopterin oxidoreductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016491

[Term]
id: GO:0016165
name: linoleate 13S-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12, GOC:lb]
synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12]
synonym: "fat oxidase activity" RELATED [EC:1.13.11.12]
synonym: "linoleate:oxygen 13-oxidoreductase activity" RELATED [EC:1.13.11.12]
synonym: "lionoleate:O2 oxidoreductase activity" RELATED [EC:1.13.11.12]
synonym: "lipoperoxidase activity" RELATED [EC:1.13.11.12]
synonym: "lipoxidase activity" RELATED [EC:1.13.11.12]
synonym: "lipoxydase activity" RELATED [EC:1.13.11.12]
synonym: "lipoxygenase activity" BROAD []
xref: EC:1.13.11.12
xref: MetaCyc:LIPOXYGENASE-RXN
xref: RHEA:22780
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0016166
name: phytoene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [PMID:29176862]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016167
name: glial cell-derived neurotrophic factor receptor activity
namespace: molecular_function
def: "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "GDNF receptor activity" EXACT [GOC:mah]
synonym: "glial cell line-derived neurotrophic factor receptor activity" EXACT [GOC:bf]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0016168
name: chlorophyll binding
namespace: molecular_function
def: "Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0016169
name: bacteriochlorophyll c binding
namespace: molecular_function
def: "Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981]
is_a: GO:0042314 ! bacteriochlorophyll binding

[Term]
id: GO:0016170
name: interleukin-15 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-15 receptor." [GOC:ai]
synonym: "IL-15" NARROW []
synonym: "interleukin-15 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0016171
name: obsolete cell surface antigen
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "cell surface antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0016172
name: antifreeze activity
namespace: molecular_function
def: "Inhibits the growth and recrystallization of ice crystals, thereby lowering the freezing point of water and preventing cellular damage at subzero temperatures. This activity is observed in various cold-adapted organisms, including certain fish, insects, and plants, and contributes to survival in extreme cold environments by stabilizing supercooled liquid states." [GOC:cjm, PMID:33317024]
comment: Note that this term was reinstated from obsolete.
is_a: GO:0050825 ! ice binding

[Term]
id: GO:0016173
name: obsolete ice nucleation inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai]
comment: This term was made obsolete because it refers to a biological process.
synonym: "ice nucleation inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0042309
consider: GO:0050825
consider: GO:0050826

[Term]
id: GO:0016174
name: NAD(P)H oxidase H2O2-forming activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1, PMID:10401672, PMID:10601291, PMID:11822874]
synonym: "dual oxidase activity" RELATED [EC:1.6.3.1]
synonym: "NAD(P)H oxidase activity" BROAD []
synonym: "NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.6.3.1]
synonym: "NADPH oxidase" BROAD [EC:1.6.3.1]
synonym: "p138tox" RELATED [EC:1.6.3.1]
synonym: "ThOX activity" NARROW [EC:1.6.3.1]
synonym: "THOX2 activity" NARROW [EC:1.6.3.1]
synonym: "thyroid NADPH oxidase activity" NARROW []
synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1]
synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1]
xref: EC:1.6.3.1
xref: Reactome:R-HSA-5693681 "DUOX1,2 reduce O2 to H2O2"
xref: Reactome:R-HSA-9698758 "FLT3 ITD- and NOX4-dependent H2O2 production"
is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

[Term]
id: GO:0016175
name: superoxide-generating NAD(P)H oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195]
synonym: "cytochrome B-245" RELATED []
xref: Reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen"
xref: Reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2"
xref: Reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide"
xref: Reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen"
xref: Reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP"
xref: Reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen"
xref: Reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen"
xref: Reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen"
xref: Reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-"
xref: Reactome:R-HSA-9673797 "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen"
is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

[Term]
id: GO:0016176
name: superoxide-generating NADPH oxidase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai]
synonym: "neutrophil cytosol factor 2" NARROW []
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0016180
name: snRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres." [PMID:15196465, PMID:31815536]
synonym: "snRNA maturation" EXACT []
synonym: "snRNA production" EXACT []
is_a: GO:0006396 ! RNA processing
is_a: GO:0016073 ! snRNA metabolic process

[Term]
id: GO:0016182
name: synaptic vesicle budding from endosome
namespace: biological_process
def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709, PMID:24596248]
subset: goslim_synapse
synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah]
synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah]
is_a: GO:0046907 ! intracellular transport
is_a: GO:0070142 ! synaptic vesicle budding
is_a: GO:0099003 ! vesicle-mediated transport in synapse
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome

[Term]
id: GO:0016183
name: synaptic vesicle coating
namespace: biological_process
def: "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles." [GOC:curators, PMID:10099709, PMID:20448150]
subset: goslim_synapse
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane

[Term]
id: GO:0016184
name: obsolete synaptic vesicle retrieval
namespace: biological_process
def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle retrieval" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016185
name: synaptic vesicle budding from presynaptic endocytic zone membrane
namespace: biological_process
def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709, PMID:20448150]
subset: goslim_synapse
synonym: "synaptic vesicle budding from pre-synaptic membrane" EXACT []
synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah]
is_a: GO:0070142 ! synaptic vesicle budding
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016186
name: obsolete synaptic vesicle fission
namespace: biological_process
def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle fission" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016187
name: obsolete synaptic vesicle internalization
namespace: biological_process
def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle internalization" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016188
name: synaptic vesicle maturation
namespace: biological_process
def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0021700 ! developmental maturation

[Term]
id: GO:0016189
name: synaptic vesicle to endosome fusion
namespace: biological_process
def: "Fusion of a synaptic vesicle with an endosome." [GOC:curators, PMID:10099709]
comment: This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.
subset: goslim_synapse
is_a: GO:0007032 ! endosome organization
is_a: GO:0048284 ! organelle fusion
relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing

[Term]
id: GO:0016191
name: synaptic vesicle uncoating
namespace: biological_process
def: "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane." [GOC:curators, PMID:10099709, PMID:24596248]
subset: goslim_synapse
synonym: "synaptic vesicle coat depolymerization" EXACT []
synonym: "synaptic vesicle coat protein depolymerization" EXACT []
is_a: GO:0072318 ! clathrin coat disassembly
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0016197
name: endosomal transport
namespace: biological_process
alt_id: GO:0032439
def: "The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]
subset: goslim_yeast
synonym: "endosome localisation" EXACT [GOC:mah]
synonym: "endosome localization" RELATED []
synonym: "endosome transport" RELATED [GOC:bf]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0016198
name: axon choice point recognition
namespace: biological_process
def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:0016199
name: axon midline choice point recognition
namespace: biological_process
def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
is_a: GO:0016198 ! axon choice point recognition

[Term]
id: GO:0016200
name: synaptic target attraction
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0008039 ! synaptic target recognition

[Term]
id: GO:0016201
name: synaptic target inhibition
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0008039 ! synaptic target recognition

[Term]
id: GO:0016202
name: regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:1901861 ! regulation of muscle tissue development
relationship: regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0016203
name: muscle attachment
namespace: biological_process
def: "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0016204
name: determination of muscle attachment site
namespace: biological_process
def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0016203 ! muscle attachment

[Term]
id: GO:0016205
name: selenocysteine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.280, PMID:10026151]
xref: EC:2.1.1.280
xref: MetaCyc:RXN-11061
xref: RHEA:26341
is_a: GO:0051995 ! Se-methyltransferase activity

[Term]
id: GO:0016206
name: catechol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a catechol + S-adenosyl-L-methionine = a guaiacol + H+ + S-adenosyl-L-homocysteine. Acts on catechols and on catecholamines such as adrenaline or noradrenaline." [EC:2.1.1.6, RHEA:17877]
synonym: "catechol methyltransferase activity" RELATED [EC:2.1.1.6]
synonym: "catecholamine O-methyltransferase activity" RELATED [EC:2.1.1.6]
synonym: "COMT I" RELATED [EC:2.1.1.6]
synonym: "COMT II" RELATED [EC:2.1.1.6]
synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6]
synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" RELATED [EC:2.1.1.6]
synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6]
xref: EC:2.1.1.6
xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ"
xref: Reactome:R-HSA-8955010 "LRTOMT transfers Met to DA, forming 3MT"
xref: RHEA:17877
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016207
name: 4-coumarate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12]
synonym: "4-coumarate-CoA synthetase activity" EXACT []
synonym: "4-coumarate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.12]
synonym: "4-coumarate:CoA ligase activity" EXACT []
synonym: "4-coumarate:coenzyme A ligase activity" RELATED [EC:6.2.1.12]
synonym: "4-coumaroyl-CoA synthase activity" RELATED [EC:6.2.1.12]
synonym: "4-coumaroyl-CoA synthetase activity" RELATED [EC:6.2.1.12]
synonym: "4-coumaryl-CoA synthetase activity" RELATED [EC:6.2.1.12]
synonym: "4CL" RELATED [EC:6.2.1.12]
synonym: "caffeolyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12]
synonym: "feruloyl CoA ligase activity" RELATED [EC:6.2.1.12]
synonym: "feruloyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12]
synonym: "hydroxycinnamate:CoA ligase activity" RELATED [EC:6.2.1.12]
synonym: "hydroxycinnamoyl CoA synthetase activity" RELATED [EC:6.2.1.12]
synonym: "p-coumaroyl CoA ligase activity" RELATED [EC:6.2.1.12]
synonym: "p-coumaryl coenzyme A synthetase activity" RELATED [EC:6.2.1.12]
synonym: "p-coumaryl-CoA ligase activity" RELATED [EC:6.2.1.12]
synonym: "p-coumaryl-CoA synthetase activity" RELATED [EC:6.2.1.12]
synonym: "p-hydroxycinnamic acid:CoA ligase activity" RELATED [EC:6.2.1.12]
synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12]
synonym: "sinapoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12]
xref: EC:6.2.1.12
xref: KEGG_REACTION:R01616
xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN
xref: RHEA:19641
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0016208
name: AMP binding
namespace: molecular_function
def: "Binding to AMP, adenosine monophosphate." [GOC:go_curators]
xref: Reactome:R-HSA-380930 "Phosphorylated AMPK binds AMP"
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0016209
name: antioxidant activity
namespace: molecular_function
def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016210
name: naringenin-chalcone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74]
synonym: "DOCS" NARROW []
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74]
xref: EC:2.3.1.74
xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN
xref: RHEA:11128
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016211
name: ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0016212
name: kynurenine-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction. Also acts on 3-hydroxykynurenine to form xanthurenate." [EC:2.6.1.7]
synonym: "kynurenine 2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.7]
synonym: "kynurenine aminotransferase activity" BROAD [EC:2.6.1.7]
synonym: "kynurenine transaminase (cyclizing)" RELATED [EC:2.6.1.7]
synonym: "kynurenine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.7]
synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT []
synonym: "L-kynurenine aminotransferase activity" RELATED [EC:2.6.1.7]
synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.7]
xref: EC:2.6.1.7
xref: Reactome:R-HSA-893583 "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate"
xref: Reactome:R-HSA-893596 "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu"
xref: Reactome:R-HSA-901097 "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0016213
name: linoleoyl-CoA desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA)." [EC:1.14.19.3, PMID:12713571, PMID:7212717]
synonym: "delta(6)-acyl CoA desaturase activity" BROAD []
synonym: "delta(6)-desaturase activity" BROAD []
synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD []
synonym: "delta6-acyl CoA desaturase activity" RELATED [EC:1.14.19.3]
synonym: "delta6-desaturase activity" RELATED [EC:1.14.19.3]
synonym: "delta6-fatty acyl-CoA desaturase activity" RELATED [EC:1.14.19.3]
synonym: "fatty acid 6-desaturase activity" BROAD []
synonym: "fatty acid delta(6)-desaturase activity" BROAD []
synonym: "fatty acid delta6-desaturase activity" RELATED [EC:1.14.19.3]
synonym: "linoleate desaturase activity" RELATED []
synonym: "linoleic acid desaturase activity" RELATED []
synonym: "linoleic desaturase activity" RELATED []
synonym: "linoleoyl CoA desaturase activity" EXACT []
synonym: "linoleoyl-coenzyme A desaturase activity" EXACT []
synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD []
synonym: "long-chain fatty acid delta6-desaturase activity" RELATED [EC:1.14.19.3]
xref: EC:1.14.19.3
xref: MetaCyc:1.14.19.3-RXN
xref: Reactome:R-HSA-2046084 "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA"
xref: Reactome:R-HSA-2046096 "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA"
xref: Reactome:R-HSA-2046097 "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA"
xref: Reactome:R-HSA-2046099 "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA"
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0016215
name: acyl-CoA desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O." [RHEA:25416]
synonym: "CoA desaturase activity" BROAD []
xref: RHEA:25416
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0016216
name: isopenicillin-N synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N." [EC:1.21.3.1, RHEA:22428]
synonym: "isopenicillin N synthase activity" RELATED [EC:1.21.3.1]
synonym: "isopenicillin-N synthetase activity" EXACT []
synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" RELATED [EC:1.21.3.1]
xref: EC:1.21.3.1
xref: KEGG_REACTION:R04872
xref: MetaCyc:1.21.3.1-RXN
xref: RHEA:22428
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0016217
name: N-ethylammeline chlorohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+." [MetaCyc:R465-RXN]
xref: MetaCyc:R465-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0016218
name: polyketide synthase activity
namespace: molecular_function
def: "Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization." [PMID:10631508]
synonym: "PKS activity" RELATED []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016222
name: procollagen-proline 4-dioxygenase complex
namespace: cellular_component
def: "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" RELATED [EC:1.14.11.2]
synonym: "prolyl 4-hydroxylase complex" BROAD [EC:1.14.11.2]
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0016223
name: beta-alanine:pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [RHEA:14077]
synonym: "beta-alanine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.18]
synonym: "beta-alanine-alpha-alanine transaminase activity" RELATED [EC:2.6.1.18]
synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT []
synonym: "L-alanine:3-oxopropanoate aminotransferase activity" RELATED [EC:2.6.1.18]
synonym: "omega-amino acid--pyruvate aminotransferase activity" RELATED [EC:2.6.1.18]
xref: EC:2.6.1.18
xref: MetaCyc:2.6.1.18-RXN
xref: Reactome:R-HSA-909776 "beta-alanine + pyruvate => 3-oxopropanoate + alanine"
xref: RHEA:14077
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0016226
name: iron-sulfur cluster assembly
namespace: biological_process
def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
subset: goslim_metagenomics
subset: goslim_pombe
synonym: "iron-sulfur cluster biosynthesis" RELATED []
synonym: "iron-sulphur cluster assembly" EXACT []
is_a: GO:0031163 ! metallo-sulfur cluster assembly

[Term]
id: GO:0016227
name: obsolete tRNA sulfurtransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4]
comment: This term was made obsolete because tRNA thionucleotide formation is a multistep process; there is no single reaction in which cysteine reacts with an activated tRNA directly
synonym: "L-cysteine:tRNA sulfurtransferase activity" RELATED [EC:2.8.1.4]
synonym: "ribonucleate sulfurtransferase activity" RELATED [EC:2.8.1.4]
synonym: "RNA sulfurtransferase activity" RELATED [EC:2.8.1.4]
synonym: "transfer ribonucleate sulfurtransferase activity" RELATED [EC:2.8.1.4]
synonym: "transfer RNA sulfurtransferase activity" RELATED [EC:2.8.1.4]
synonym: "transfer RNA thiolase activity" RELATED [EC:2.8.1.4]
synonym: "tRNA sulfurtransferase activity" EXACT []
synonym: "tRNA sulphurtransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0034227
consider: GO:0016783

[Term]
id: GO:0016229
name: steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016230
name: sphingomyelin phosphodiesterase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai]
synonym: "neutral sphingomyelinase activator" EXACT []
is_a: GO:0016004 ! phospholipase activator activity

[Term]
id: GO:0016231
name: beta-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [PMID:29143882, PMID:37590576]
is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity

[Term]
id: GO:0016232
name: HNK-1 sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)." [PMID:9478973]
synonym: "HNK-1 sulphotransferase activity" EXACT []
xref: Reactome:R-HSA-6786048 "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0016233
name: telomere capping
namespace: biological_process
def: "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]
synonym: "telomere end protection" EXACT []
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0016234
name: inclusion body
namespace: cellular_component
def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]
synonym: "cellular inclusion" RELATED [NIF_Subcellular:sao120573470]
synonym: "neuronal cytoplasmic inclusion" NARROW []
xref: NIF_Subcellular:sao120573470
xref: Wikipedia:Inclusion_bodies
is_a: GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0016235
name: aggresome
namespace: cellular_component
def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744]
xref: Wikipedia:Aggresome
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0016236
name: macroautophagy
namespace: biological_process
alt_id: GO:0034262
def: "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]
synonym: "autophagy" BROAD []
synonym: "selective autophagy" NARROW []
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0016237
name: microautophagy
namespace: biological_process
def: "A type of autophagy where cytosolic components are ingested by late endosomes, lysosomes or yeast-type lytic vacuoles by direct invagination of the compartment membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964]
synonym: "lysosomal microautophagy" BROAD []
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0016239
name: positive regulation of macroautophagy
namespace: biological_process
def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]
synonym: "activation of macroautophagy" NARROW []
synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "stimulation of macroautophagy" NARROW []
synonym: "up regulation of macroautophagy" EXACT []
synonym: "up-regulation of macroautophagy" EXACT []
synonym: "upregulation of macroautophagy" EXACT []
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:0016241 ! regulation of macroautophagy
relationship: positively_regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016240
name: autophagosome membrane docking
namespace: biological_process
def: "The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:autophagy, GOC:mah]
synonym: "autophagic vacuole docking" EXACT [GOC:autophagy]
is_a: GO:0140056 ! organelle localization by membrane tethering
relationship: part_of GO:0097352 ! autophagosome maturation

[Term]
id: GO:0016241
name: regulation of macroautophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]
synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
relationship: regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016242
name: negative regulation of macroautophagy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]
synonym: "down regulation of macroautophagy" EXACT []
synonym: "down-regulation of macroautophagy" EXACT []
synonym: "downregulation of macroautophagy" EXACT []
synonym: "inhibition of macroautophagy" NARROW []
synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:0016241 ! regulation of macroautophagy
relationship: negatively_regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016243
name: regulation of autophagosome size
namespace: biological_process
def: "Any process that modulates the size of the autophagosome." [GOC:autophagy, GOC:krc]
synonym: "regulation of autophagic vacuole size" EXACT [GOC:autophagy]
is_a: GO:0032535 ! regulation of cellular component size
is_a: GO:1905037 ! autophagosome organization

[Term]
id: GO:0016247
name: channel regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]
is_a: GO:0141108 ! transporter regulator activity

[Term]
id: GO:0016248
name: channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of a channel." [GOC:mah]
is_a: GO:0016247 ! channel regulator activity
is_a: GO:0141110 ! transporter inhibitor activity

[Term]
id: GO:0016250
name: N-sulfoglucosamine sulfohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate." [EC:3.10.1.1]
synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" RELATED [EC:3.10.1.1]
synonym: "heparin sulfamidase activity" RELATED [EC:3.10.1.1]
synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" RELATED [EC:3.10.1.1]
synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT []
synonym: "sulfoglucosamine sulfamidase activity" RELATED [EC:3.10.1.1]
synonym: "sulphamidase activity" RELATED [EC:3.10.1.1]
xref: EC:3.10.1.1
xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN
xref: Reactome:R-HSA-1678708 "SGSH hydrolyses Heparan sulfate chain(2)"
xref: Reactome:R-HSA-2090043 "SGSH hydrolyses Heparan sulfate chain(7)"
xref: Reactome:R-HSA-2263444 "Defective SGSH does not hydrolyse Heparan sulfate chain(7)"
xref: Reactome:R-HSA-9036050 "Defective SGSH does not hydrolyse Heparan sulfate chain(2)"
xref: RHEA:17881
is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds

[Term]
id: GO:0016251
name: RNA polymerase II general transcription initiation factor activity
namespace: molecular_function
alt_id: GO:0000983
alt_id: GO:0001075
alt_id: GO:0003703
def: "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]
comment: General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur.
synonym: "basal RNA polymerase II transcription factor activity" EXACT []
synonym: "general RNA polymerase II transcription factor activity" EXACT []
synonym: "GTF2 activity" EXACT []
synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity" RELATED []
synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" RELATED []
synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" RELATED []
synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly" RELATED []
synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding" RELATED []
is_a: GO:0140223 ! general transcription initiation factor activity

[Term]
id: GO:0016252
name: obsolete nonspecific RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "nonspecific RNA polymerase II transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0006366
consider: GO:0016251

[Term]
id: GO:0016254
name: obsolete preassembly of GPI anchor in ER membrane
namespace: biological_process
def: "OBSOLETE. The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using the parent term GPI anchor biosynthetic process GO:0006506
synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT []
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0016255
name: attachment of GPI anchor to protein
namespace: biological_process
def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]
is_a: GO:0051604 ! protein maturation
relationship: part_of GO:0180046 ! GPI anchored protein biosynthesis

[Term]
id: GO:0016256
name: N-glycan processing to lysosome
namespace: biological_process
def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595]
is_a: GO:0006491 ! N-glycan processing
relationship: part_of GO:0006622 ! protein targeting to lysosome

[Term]
id: GO:0016257
name: N-glycan processing to secreted and cell-surface N-glycans
namespace: biological_process
def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595]
is_a: GO:0006491 ! N-glycan processing

[Term]
id: GO:0016258
name: N-glycan diversification
namespace: biological_process
def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595]
is_a: GO:0006491 ! N-glycan processing

[Term]
id: GO:0016259
name: selenocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]
synonym: "selenocysteine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0016260
name: selenocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]
synonym: "selenocysteine anabolism" EXACT []
synonym: "selenocysteine biosynthesis" EXACT []
synonym: "selenocysteine formation" EXACT []
synonym: "selenocysteine synthesis" EXACT []
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0016259 ! selenocysteine metabolic process

[Term]
id: GO:0016261
name: selenocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]
synonym: "selenocysteine breakdown" EXACT []
synonym: "selenocysteine catabolism" EXACT []
synonym: "selenocysteine degradation" EXACT []
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0016259 ! selenocysteine metabolic process

[Term]
id: GO:0016262
name: protein N-acetylglucosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0016253
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94]
synonym: "N-GlcNAc transferase activity" RELATED [EC:2.4.1.94]
synonym: "protein N-GlcNAc transferase activity" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT []
synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity" EXACT []
synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT []
xref: EC:2.4.1.94
xref: MetaCyc:2.4.1.94-RXN
xref: RHEA:16533
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0016263
name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma]
synonym: "Core 1 GalT" RELATED []
synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.122]
synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.122]
synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" RELATED [EC:2.4.1.122]
xref: EC:2.4.1.122
xref: MetaCyc:2.4.1.122-RXN
xref: Reactome:R-HSA-1964505 "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)"
xref: Reactome:R-HSA-6785524 "Defective C1GALT1C1 does not bind C1GALT1"
xref: RHEA:15621
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0016264
name: gap junction assembly
namespace: biological_process
def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363]
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0016265
name: obsolete death
namespace: biological_process
def: "OBSOLETE. A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, GOC:mtg_apoptosis, ISBN:0877797099]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
xref: Wikipedia:Death
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0016266
name: O-glycan processing
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]
is_a: GO:0006493 ! protein O-linked glycosylation

[Term]
id: GO:0016267
name: core 1 O-glycan biosynthetic process
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc. Core 1 occurs on most glycoproteins, and is often substituted with sialic acid residues or with various other sugars." [GOC:mah, GOC:pr, PMID:10580130, PMID:33775405]
synonym: "core 1 O-glycan biosynthesis" EXACT []
synonym: "mucin type O-glycosylation" RELATED [PMID:33775405]
synonym: "O-glycan processing, core 1" EXACT []
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016268
name: core 2 O-glycan biosynthetic process
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc or Core 1) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130, PMID:33775405]
synonym: "core 2 O-glycan biosynthesis" EXACT []
synonym: "O-glycan processing, core 2" EXACT []
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016269
name: core 3 O-glycan biosynthetic process
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130, PMID:33775405]
synonym: "core 3 O-glycan biosynthesis" EXACT []
synonym: "O-glycan processing, core 3" EXACT []
xref: MetaCyc:PWY-7435
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016270
name: obsolete O-glycan processing, core 4
namespace: biological_process
def: "OBSOLETE. The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0016271
name: obsolete tissue death
namespace: biological_process
def: "OBSOLETE. A permanent cessation of all vital functions of a tissue." [GOC:dph, GOC:mtg_apoptosis]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0016272
name: prefoldin complex
namespace: cellular_component
def: "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
synonym: "GIM complex" NARROW []
xref: Wikipedia:Prefoldin
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0016273
name: arginine N-methyltransferase activity
namespace: molecular_function
def: "Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah]
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016274
name: protein-arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [GOC:mah, PMID:12351636, PMID:31284549]
synonym: "PRMT activity" EXACT []
xref: Reactome:R-HSA-191790 "Loading and methylation of Sm proteins onto SMN Complexes"
xref: Reactome:R-HSA-5205798 "PRMT1,PRMT6 methylate arginine-4 of histone H4"
xref: Reactome:R-HSA-5205820 "PRMT6 methylates arginine-4 of histone H2A (H2AR3)"
xref: Reactome:R-HSA-5205822 "CARM1 methylates arginine-18 (H3R17) of histone H3"
xref: Reactome:R-HSA-5205824 "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)"
xref: Reactome:R-HSA-5205867 "PRMT1 methylates arginine-12 of histone H2A (H2AR11)"
xref: Reactome:R-HSA-5218952 "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)"
xref: Reactome:R-HSA-5229010 "CARM1 methylates arginine-27 of histone H3 (H3R26)"
xref: Reactome:R-HSA-5229203 "PRMT6 methylates histone H2A arginine-30 (H2AR29)"
xref: Reactome:R-HSA-5661126 "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4"
xref: Reactome:R-HSA-8879123 "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2"
xref: Reactome:R-HSA-8934735 "PRMT1 arginine-methylates RUNX1"
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0016273 ! arginine N-methyltransferase activity

[Term]
id: GO:0016275
name: obsolete [cytochrome c]-arginine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [GOC:ma]
comment: Specific substrate mentioned
synonym: "cytochrome c-arginine N-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED []
synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED []
is_obsolete: true
replaced_by: GO:0035241

[Term]
id: GO:0016277
name: obsolete [myelin basic protein]-arginine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [PMID:6177833]
comment: This term represents an activity acting on a specific gene product (not a class). the myelin bsic protein is often used as a substrate for assaying for enzyme activity. The original EC for this entry has been depreciated and transferred to 4 other ECs.
is_obsolete: true

[Term]
id: GO:0016278
name: lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah]
xref: Reactome:R-HSA-3222237 "SMYD2 methylates TP53"
xref: Reactome:R-HSA-6805730 "SETD9 methylates TP53"
xref: Reactome:R-HSA-6805740 "SETD8 methylates TP53"
xref: Reactome:R-HSA-6805755 "EHMT1:EHMT2 dimethylates TP53"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016279
name: protein-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]
synonym: "protein (lysine) methyltransferase activity" EXACT []
synonym: "protein lysine methylase activity" EXACT []
xref: Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27"
xref: Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex"
xref: Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB"
xref: Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A"
xref: Reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8"
xref: Reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2"
xref: Reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN"
xref: Reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP"
xref: Reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1"
xref: Reactome:R-HSA-9844111 "EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP"
xref: Reactome:R-HSA-9854315 "CSKMT methylates Citrate Synthase"
xref: RHEA:51736
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0016278 ! lysine N-methyltransferase activity

[Term]
id: GO:0016281
name: eukaryotic translation initiation factor 4F complex
namespace: cellular_component
def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]
synonym: "cytoplasmic cap-binding complex" EXACT []
synonym: "eIF-4F" EXACT []
synonym: "eukaryotic translation initiation factor 4 complex" BROAD []
is_a: GO:0034518 ! RNA cap binding complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0016282
name: eukaryotic 43S preinitiation complex
namespace: cellular_component
def: "A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049, PMID:16510876, PMID:25742741, PMID:29735639]
synonym: "eukaryotic 43S pre-initiation complex" EXACT []
is_a: GO:0070993 ! translation preinitiation complex

[Term]
id: GO:0016284
name: obsolete alanine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
synonym: "alanine aminopeptidase activity" EXACT []
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0016285
name: alanyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14]
synonym: "aminopolypeptidase activity" BROAD [EC:3.4.11.14]
synonym: "arylamidase activity" NARROW [EC:3.4.11.14]
synonym: "cytosol alanyl aminopeptidase activity" EXACT []
synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14]
synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14]
synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "membrane alanine aminopeptidase" NARROW []
synonym: "membrane alanyl aminopeptidase" NARROW []
synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "soluble alanyl aminopeptidase activity" RELATED [EC:3.4.11.14]
synonym: "thiol-activated aminopeptidase activity" RELATED [EC:3.4.11.14]
xref: EC:3.4.11.14
xref: MetaCyc:3.4.11.14-RXN
is_a: GO:0004177 ! aminopeptidase activity

[Term]
id: GO:0016286
name: small conductance calcium-activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
synonym: "SK calcium-activated potassium channel activity" EXACT []
synonym: "SK KCa channels" EXACT []
synonym: "small conductance KCa channels" EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0016287
name: glycerone-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17657]
synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" RELATED [EC:2.3.1.42]
synonym: "dihydroxyacetone phosphate acyltransferase activity" RELATED [EC:2.3.1.42]
xref: EC:2.3.1.42
xref: KEGG_REACTION:R01013
xref: MetaCyc:2.3.1.42-RXN
xref: Reactome:R-HSA-1483002 "DHAP is converted to 1-acyl GO3P by GNPAT"
xref: Reactome:R-HSA-75879 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH"
xref: RHEA:17657
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0016289
name: acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+." [RHEA:70423]
synonym: "CoA hydrolase activity" BROAD []
xref: Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH"
xref: RHEA:70423
is_a: GO:0016790 ! thiolester hydrolase activity
is_a: GO:0160215 ! deacylase activity

[Term]
id: GO:0016290
name: obsolete palmitoyl-CoA hydrolase activity
namespace: molecular_function
alt_id: GO:0016293
def: "OBSOLETE. Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of long-chain fatty acyl-CoA hydrolase activity ; GO:0052816.
synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2]
synonym: "long-chain fatty-acyl-CoA hydrolase activity" BROAD []
synonym: "palmitoyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.2]
synonym: "palmitoyl thioesterase activity" RELATED [EC:3.1.2.2]
synonym: "palmitoyl-CoA deacylase activity" RELATED [EC:3.1.2.2]
synonym: "palmityl thioesterase activity" RELATED [EC:3.1.2.2]
synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2]
synonym: "palmityl-CoA deacylase activity" RELATED [EC:3.1.2.2]
is_obsolete: true
replaced_by: GO:0052816

[Term]
id: GO:0016295
name: obsolete myristoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H+." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of fatty acyl-[ACP] hydrolase activity ; GO:0016297.
synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "myristoyl-ACP hydrolase activity" EXACT []
synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT []
synonym: "tetradecanoyl-ACP hydrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016297

[Term]
id: GO:0016296
name: obsolete palmitoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hexadecanoyl-[ACP] + H2O = H+ + hexadecanoate + holo-[ACP]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of fatty acyl-[ACP] hydrolase activity ; GO:0016297.
synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "palmitoyl-ACP hydrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016297

[Term]
id: GO:0016297
name: fatty acyl-[ACP] hydrolase activity
namespace: molecular_function
alt_id: GO:0010281
alt_id: GO:0016294
def: "Catalysis of the reaction: a fatty acyl-[ACP] + H2O = a fatty acid + H+ + holo-[acyl-carrier protein]." [RHEA:44596]
synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "acyl-[acyl-carrier-protein] hydrolase activity" EXACT []
synonym: "acyl-ACP hydrolase activity" EXACT []
synonym: "acyl-ACP thioesterase activity" EXACT []
synonym: "acyl-ACP-hydrolase activity" RELATED []
synonym: "acyl-acyl carrier protein hydrolase activity" RELATED []
synonym: "acyl-acyl-carrier-protein hydrolase activity" RELATED []
xref: MetaCyc:RXN-7902
xref: Reactome:R-HSA-5655955 "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer"
xref: RHEA:44596
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0016298
name: lipase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a lipid." [GOC:mah, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
xref: Reactome:R-HSA-163402 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid"
xref: Reactome:R-HSA-163432 "cholesterol ester + H2O -> cholesterol + fatty acid"
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0016299
name: obsolete regulator of G-protein signaling activity
namespace: molecular_function
def: "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators]
comment: This term was made obsolete because it refers to a combination of a function and a process.
synonym: "regulator of G protein signaling activity" EXACT []
synonym: "regulator of G protein signalling activity" EXACT []
synonym: "regulator of G-protein signaling activity" EXACT []
synonym: "regulator of G-protein signalling activity" EXACT []
synonym: "RGS" EXACT []
is_obsolete: true
consider: GO:0005095
consider: GO:0034260
consider: GO:0045744

[Term]
id: GO:0016300
name: tRNA (uridine) methyltransferase activity
namespace: molecular_function
alt_id: GO:0016431
def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah]
synonym: "tRNA (uracil) methyltransferase activity" EXACT []
is_a: GO:0008175 ! tRNA methyltransferase activity

[Term]
id: GO:0016301
name: kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "phosphokinase activity" EXACT []
xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm"
xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016303
name: 1-phosphatidylinositol-3-kinase activity
namespace: molecular_function
alt_id: GO:0004429
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+." [EC:2.7.1.137, RHEA:12709]
synonym: "1-phosphatidylinositol 3-kinase activity" EXACT []
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137]
synonym: "PI3K" EXACT []
synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137]
synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137]
synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137]
xref: EC:2.7.1.137
xref: KEGG_REACTION:R03362
xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
xref: Reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3"
xref: Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K"
xref: Reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane"
xref: Reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane"
xref: Reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane"
xref: Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3"
xref: Reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns"
xref: Reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P"
xref: Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3"
xref: Reactome:R-HSA-9680389 "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2"
xref: RHEA:12709
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0016304
name: obsolete phosphatidylinositol 3-kinase activity, class I
namespace: molecular_function
def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase activity, class I" EXACT []
is_obsolete: true
consider: GO:0016303
consider: GO:0035005
consider: GO:0046934

[Term]
id: GO:0016305
name: obsolete phosphatidylinositol 3-kinase activity, class II
namespace: molecular_function
def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase activity, class II" EXACT []
synonym: "PI3KC2" EXACT []
is_obsolete: true
consider: GO:0016303
consider: GO:0035005
consider: GO:0046934

[Term]
id: GO:0016306
name: obsolete phosphatidylinositol 3-kinase activity, class III
namespace: molecular_function
def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase activity, class III" EXACT []
is_obsolete: true
replaced_by: GO:0016303

[Term]
id: GO:0016307
name: obsolete phosphatidylinositol phosphate kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [PMID:9759495]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "phosphatidylinositol monophosphate kinase activity" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0052742

[Term]
id: GO:0016308
name: 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: molecular_function
alt_id: GO:0004431
alt_id: GO:0045215
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+." [EC:2.7.1.68, RHEA:14425]
synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.68]
synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68]
synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68]
synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" RELATED [EC:2.7.1.68]
synonym: "PI(4)5K" RELATED []
synonym: "PIP kinase activity" BROAD [EC:2.7.1.68]
synonym: "PIP5K" EXACT []
synonym: "PtdIns(4)P-5-kinase activity" RELATED [EC:2.7.1.68]
synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68]
xref: EC:2.7.1.68
xref: KEGG_REACTION:R03469
xref: MetaCyc:2.7.1.68-RXN
xref: Reactome:R-HSA-1676082 "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane"
xref: Reactome:R-HSA-3772436 "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2"
xref: Reactome:R-HSA-8868066 "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2"
xref: RHEA:14425
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0016309
name: 1-phosphatidylinositol-5-phosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+." [EC:2.7.1.149]
synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" RELATED [EC:2.7.1.149]
synonym: "PIP4K" EXACT []
synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149]
xref: EC:2.7.1.149
xref: MetaCyc:2.7.1.149-RXN
xref: Reactome:R-HSA-1675776 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane"
xref: Reactome:R-HSA-6811522 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus"
xref: RHEA:12280
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0016310
name: phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
subset: gocheck_obsoletion_candidate
subset: goslim_chembl
subset: goslim_metagenomics
xref: Wikipedia:Phosphorylation
is_a: GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0016311
name: dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
subset: gocheck_obsoletion_candidate
xref: Wikipedia:Dephosphorylation
is_a: GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0016312
name: inositol bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb]
xref: Reactome:R-HSA-6809561 "I(1,3)P2 is dephosphorylated into I1P by MTMR7"
xref: Reactome:R-HSA-6809565 "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9"
xref: RHEA:57840
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0016313
name: obsolete inositol-1,4,5-trisphosphate phosphatase
namespace: molecular_function
def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb]
comment: This term was made obsolete because it is a redundant grouping term with only one child.
synonym: "inositol-1,4,5-trisphosphate phosphatase" EXACT []
is_obsolete: true
consider: GO:0046030

[Term]
id: GO:0016314
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]
synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.67]
synonym: "MMAC1" RELATED [EC:3.1.3.67]
synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.67]
synonym: "PI(3)P 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580]
synonym: "PI(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580]
synonym: "PtdIns(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580]
xref: EC:3.1.3.67
xref: MetaCyc:3.1.3.67-RXN
xref: Reactome:R-HSA-199456 "PTEN dephosphorylates PIP3"
xref: Reactome:R-HSA-202237 "Hydrolysis of PIP3 to PI(3,4)P2"
xref: Reactome:R-HSA-2317387 "PTEN cancer mutants do not dephosphorylate PIP3"
xref: RHEA:25017
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity

[Term]
id: GO:0016316
name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
namespace: molecular_function
alt_id: GO:0004440
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:hb, RHEA:17193]
synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" RELATED [EC:3.1.3.66]
synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66]
xref: EC:3.1.3.66
xref: MetaCyc:3.1.3.66-RXN
xref: Reactome:R-HSA-1676162 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane"
xref: Reactome:R-HSA-1676164 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane"
xref: RHEA:17193
is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity
is_a: GO:0106017 ! phosphatidylinositol-3,4-bisphosphate phosphatase activity

[Term]
id: GO:0016318
name: ommatidial rotation
namespace: biological_process
def: "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity

[Term]
id: GO:0016319
name: mushroom body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0016320
name: endoplasmic reticulum membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid]
synonym: "ER membrane fusion" EXACT []
is_a: GO:0007029 ! endoplasmic reticulum organization
is_a: GO:0090158 ! endoplasmic reticulum membrane organization
is_a: GO:0090174 ! organelle membrane fusion

[Term]
id: GO:0016321
name: female meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
is_a: GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0007143 ! female meiotic nuclear division

[Term]
id: GO:0016322
name: neuron remodeling
namespace: biological_process
def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
synonym: "axon pruning" NARROW [GOC:sart, PMID:18267091]
synonym: "neuron remodelling" EXACT []
synonym: "neuronal remodeling" EXACT []
is_a: GO:0042551 ! neuron maturation

[Term]
id: GO:0016323
name: basolateral plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0009925 ! basal plasma membrane

[Term]
id: GO:0016324
name: apical plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0016325
name: oocyte microtubule cytoskeleton organization
namespace: biological_process
alt_id: GO:0048130
def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
synonym: "oocyte microtubule cytoskeleton organisation" EXACT []
is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0016326
name: obsolete kinesin motor activity
namespace: molecular_function
def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb]
comment: This term was made obsolete because it represents a gene product.
synonym: "kinesin motor activity" EXACT []
is_obsolete: true
replaced_by: GO:0003777

[Term]
id: GO:0016327
name: apicolateral plasma membrane
namespace: cellular_component
def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
synonym: "apical lateral plasma membrane" EXACT [PMID:24496625]
is_a: GO:0098590 ! plasma membrane region

[Term]
id: GO:0016328
name: lateral plasma membrane
namespace: cellular_component
def: "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0016329
name: obsolete apoptosis regulator activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "apoptosis regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0042981

[Term]
id: GO:0016330
name: second mitotic wave involved in compound eye morphogenesis
namespace: biological_process
def: "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
synonym: "second mitotic wave during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0016331
name: morphogenesis of embryonic epithelium
namespace: biological_process
def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0016332
name: establishment or maintenance of polarity of embryonic epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium

[Term]
id: GO:0016333
name: morphogenesis of follicular epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0016334
name: establishment or maintenance of polarity of follicular epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium

[Term]
id: GO:0016335
name: morphogenesis of larval imaginal disc epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0002168 ! instar larval development
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0016336
name: establishment or maintenance of polarity of larval imaginal disc epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium

[Term]
id: GO:0016338
name: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-independent cell adhesion molecule activity" RELATED []
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0016339
name: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-dependent cell adhesion molecule activity" RELATED []
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0016340
name: calcium-dependent cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0016341
name: obsolete other collagen
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
synonym: "other collagen" EXACT []
is_obsolete: true
replaced_by: GO:0005581

[Term]
id: GO:0016342
name: catenin complex
namespace: cellular_component
def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0019897 ! extrinsic component of plasma membrane

[Term]
id: GO:0016343
name: obsolete cytoskeletal anchoring activity
namespace: molecular_function
def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
comment: This term was made obsolete because it represents a biological process.
synonym: "cytoskeletal anchoring activity" EXACT []
is_obsolete: true

[Term]
id: GO:0016344
name: meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai]
synonym: "chromosome migration to spindle pole during meiosis" EXACT []
synonym: "chromosome movement towards spindle pole during meiosis" EXACT []
synonym: "meiotic chromosome movement" BROAD []
synonym: "meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0051305 ! chromosome movement towards spindle pole
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0016345
name: female meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai]
synonym: "chromosome movement towards spindle pole during female meiosis" EXACT []
synonym: "female meiotic chromosome movement" BROAD []
synonym: "female meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0016321 ! female meiosis chromosome segregation

[Term]
id: GO:0016346
name: male meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai]
synonym: "chromosome movement towards spindle pole during male meiosis" EXACT []
synonym: "male meiotic chromosome movement" BROAD []
synonym: "male meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0007060 ! male meiosis chromosome segregation

[Term]
id: GO:0016347
name: obsolete calcium-independent cell adhesion molecule activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "calcium-independent cell adhesion molecule activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0007161
consider: GO:0016338

[Term]
id: GO:0016348
name: imaginal disc-derived leg joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0036011 ! imaginal disc-derived leg segmentation

[Term]
id: GO:0016351
name: obsolete drug susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "drug susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009410

[Term]
id: GO:0016352
name: obsolete insecticide susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "insecticide susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0017085

[Term]
id: GO:0016353
name: obsolete carbamate susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "carbamate susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046681

[Term]
id: GO:0016354
name: obsolete cyclodiene susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "cyclodiene susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046682

[Term]
id: GO:0016355
name: obsolete DDT susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "DDT susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046680

[Term]
id: GO:0016356
name: obsolete organophosphorus susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "organophosphorus susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046683

[Term]
id: GO:0016357
name: obsolete pyrethroid susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "pyrethroid susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046684

[Term]
id: GO:0016358
name: dendrite development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]
is_a: GO:0031175 ! neuron projection development
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0016360
name: sensory organ precursor cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph]
is_a: GO:0060582 ! cell fate determination involved in pattern specification
relationship: part_of GO:0008052 ! sensory organ boundary specification

[Term]
id: GO:0016361
name: activin receptor activity, type I
namespace: molecular_function
def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651]
synonym: "type I activin receptor activity" EXACT []
is_a: GO:0017002 ! activin receptor activity

[Term]
id: GO:0016362
name: activin receptor activity, type II
namespace: molecular_function
def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor." [GOC:mah, PMID:8622651]
synonym: "type II activin receptor activity" EXACT []
xref: Reactome:R-HSA-201443 "Type II receptor phosphorylates type I receptor"
is_a: GO:0017002 ! activin receptor activity

[Term]
id: GO:0016363
name: nuclear matrix
namespace: cellular_component
def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
synonym: "nucleoskeleton" EXACT []
xref: Wikipedia:Nuclear_matrix
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0034399 ! nuclear periphery

[Term]
id: GO:0016401
name: palmitoyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide." [GOC:jsg]
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0016402
name: pristanoyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide." [GOC:jsg, RHEA:40459]
xref: Reactome:R-HSA-389889 "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA"
xref: Reactome:R-HSA-389891 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)"
xref: RHEA:40459
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0016403
name: dimethylargininase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18]
synonym: "dimethylarginine dimethylaminohydrolase activity" RELATED [EC:3.5.3.18]
synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" RELATED [EC:3.5.3.18]
synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" RELATED [EC:3.5.3.18]
synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" RELATED [EC:3.5.3.18]
xref: EC:3.5.3.18
xref: MetaCyc:DIMETHYLARGININASE-RXN
xref: Reactome:R-HSA-5693373 "DDAH1 hydrolyses ADMA to DMA and L-Cit"
xref: RHEA:17305
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016404
name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" RELATED [EC:1.1.1.141]
synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" RELATED [EC:1.1.1.141]
synonym: "15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.141]
synonym: "15-hydroxyprostanoic dehydrogenase activity" RELATED [EC:1.1.1.141]
synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141]
synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" RELATED [EC:1.1.1.141]
synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.141]
synonym: "prostaglandin dehydrogenase activity" RELATED [EC:1.1.1.141]
xref: EC:1.1.1.141
xref: MetaCyc:1.1.1.141-RXN
xref: Reactome:R-HSA-2161662 "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD"
xref: Reactome:R-HSA-2161779 "LXA4 is oxidised to 15k-LXA4 by HPGD"
xref: Reactome:R-HSA-9023968 "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1"
xref: Reactome:R-HSA-9024766 "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1"
xref: RHEA:11876
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016405
name: CoA-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]
xref: Reactome:R-HSA-159443 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate"
xref: Reactome:R-HSA-159567 "ACSM2B-like proteins transform ST to ST-CoA"
xref: Reactome:R-HSA-177157 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate"
xref: Reactome:R-HSA-6798345 "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA"
xref: Reactome:R-HSA-9749971 "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA"
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0016406
name: carnitine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016407
name: acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]
synonym: "acetylase activity" EXACT []
xref: Reactome:R-HSA-5628871 "BRD7 promotes EP300-mediated acetylation of TP53"
xref: Reactome:R-HSA-5660660 "p300 acetylates RELA subunit"
xref: Reactome:R-HSA-5682044 "KAT5 acetylates ATM at DNA DSBs"
xref: Reactome:R-HSA-6792712 "KAT5 acetylates ATM at shortened telomeres"
xref: Reactome:R-HSA-6805638 "KAT6A acetylates TP53"
xref: Reactome:R-HSA-73736 "Acetylation of SL1"
xref: Reactome:R-HSA-9854415 "ACAT1 tetramer acetylates IDH2 dimer"
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016408
name: C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016409
name: palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]
comment: Note that this term should not be confused with 'palmitoleoyltransferase activity ; GO:1990698'.
xref: Reactome:R-HSA-5686304 "ZDHHC2 transfers PALM from PALM-CoA to CKAP4"
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016410
name: N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
xref: Reactome:R-HSA-177160 "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A"
xref: Reactome:R-HSA-6792572 "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST"
xref: Reactome:R-HSA-9858752 "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT"
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016411
name: acylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]
xref: Reactome:R-HSA-1482647 "2-MAG and DAG are transacylated to TAG by PNPLA2/3"
xref: Reactome:R-HSA-1482654 "2-MAG is transacylated to DAG by PNPLA2/3"
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016412
name: serine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a fatty acyl-CoA + L-seryl-[protein] = CoA + O-fatty acyl-L-seryl-[protein]." [RHEA:68272]
xref: RHEA:68272
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016413
name: O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0016414
name: diglucosylglycerate octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA." [RHEA:56868]
synonym: "O-octanoyltransferase activity" BROAD []
xref: EC:2.3.1.273
xref: RHEA:56868
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016415
name: obsolete octanoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai]
comment: This term was obsoleted because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0033819

[Term]
id: GO:0016416
name: O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: Reactome:R-HSA-2404137 "LRAT esterifies RBP1:atROL and FACYLs to atREs"
xref: Reactome:R-HSA-2453855 "LRAT esterifies RBP1:atROL and FACYLs to atREs"
xref: Reactome:R-HSA-2466710 "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs"
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0016417
name: S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016418
name: S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016417 ! S-acyltransferase activity

[Term]
id: GO:0016419
name: S-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016417 ! S-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0016420
name: malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016421
name: CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah]
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0016422
name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62]
synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" RELATED [EC:2.1.1.62]
synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" RELATED [EC:2.1.1.62]
synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" RELATED [EC:2.1.1.62]
xref: EC:2.1.1.62
xref: MetaCyc:2.1.1.62-RXN
xref: RHEA:22744
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0016423
name: tRNA (guanine) methyltransferase activity
namespace: molecular_function
alt_id: GO:0016424
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [GOC:go-curators]
synonym: "tRNA (guanosine) methyltransferase activity" EXACT []
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016426
name: tRNA (adenine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine." [GOC:go-curators]
synonym: "tRNA (adenine-C2-)-methyltransferase activity" BROAD []
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016427
name: tRNA (cytidine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [GOC:go-curators]
synonym: "tRNA (cytosine) methyltransferase activity" EXACT []
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016428
name: tRNA (cytidine-5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49)." [RHEA:61468]
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" RELATED []
synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" RELATED []
synonym: "transfer RNA cytosine 5-methyltransferase activity" RELATED []
synonym: "tRNA (cytosine-5-)-methyltransferase activity" EXACT []
xref: Reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)"
xref: Reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)"
xref: Reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)"
xref: Reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)"
xref: Reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)"
xref: RHEA:61468
is_a: GO:0016427 ! tRNA (cytidine) methyltransferase activity

[Term]
id: GO:0016429
name: obsolete tRNA (adenine-N1)-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36]
comment: This term was obsoleted because it is an unnecessary grouping term and was obsoleted by EC.
synonym: "1-methyladenine transfer RNA methyltransferase activity" RELATED [EC:2.1.1.36]
synonym: "adenine-1-methylase activity" RELATED [EC:2.1.1.36]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" RELATED [EC:2.1.1.36]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" RELATED [EC:2.1.1.36]
synonym: "transfer ribonucleate adenine 1-methyltransferase activity" RELATED [EC:2.1.1.36]
synonym: "transfer RNA (adenine-1) methyltransferase activity" RELATED [EC:2.1.1.36]
synonym: "tRNA (adenine-N1-)-methyltransferase activity" EXACT []
is_obsolete: true
consider: GO:0043827
consider: GO:0160105
consider: GO:0160106
consider: GO:0160107

[Term]
id: GO:0016430
name: tRNA (adenine-N6)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" RELATED [EC:2.1.1.55]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" RELATED [EC:2.1.1.55]
synonym: "tRNA (adenine-N6-)-methyltransferase activity" EXACT []
xref: EC:2.1.1.55
xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN
xref: RHEA:16785
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0016432
name: tRNA-uridine aminocarboxypropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]
synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" RELATED [EC:2.5.1.25]
xref: EC:2.5.1.25
xref: MetaCyc:2.5.1.25-RXN
xref: RHEA:12300
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0016433
name: rRNA (adenine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators]
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016434
name: rRNA (cytosine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine." [GOC:go-curators]
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016435
name: rRNA (guanine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine." [GOC:curators]
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016436
name: rRNA (uridine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine." [GOC:go-curators]
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016438
name: tRNA-queuosine(34) beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + queuosine34 in tRNA(Asp) = GDP + H+ + O-4''-alpha-D-mannosylqueuosine34 in tRNA(Asp)." [RHEA:12885]
synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.110]
synonym: "tRNA-queuosine beta-mannosyltransferase activity" BROAD []
xref: EC:2.4.1.110
xref: MetaCyc:2.4.1.110-RXN
xref: RHEA:12885
is_a: GO:0000030 ! mannosyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0016441
name: post-transcriptional gene silencing
namespace: biological_process
def: "The inactivation of gene expression that occurs after transcription." [GOC:mah, PMID:15020054]
synonym: "posttranscriptional gene silencing" EXACT [GOC:vw]
synonym: "PTGS" EXACT []
xref: Wikipedia:Post_transcriptional_gene_silencing
is_a: GO:0010608 ! post-transcriptional regulation of gene expression
is_a: GO:0010629 ! negative regulation of gene expression

[Term]
id: GO:0016442
name: RISC complex
namespace: cellular_component
alt_id: GO:0035068
def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
synonym: "micro-ribonucleoprotein complex" RELATED []
synonym: "miRNP complex" RELATED []
synonym: "RNA-induced silencing complex" EXACT []
xref: Wikipedia:RNA-induced_silencing_complex
is_a: GO:0031332 ! RNAi effector complex

[Term]
id: GO:0016443
name: obsolete bidentate ribonuclease III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644]
comment: This term was obsoleted because it represents the same reaction as GO:0004525.
synonym: "bidentate RNase III activity" EXACT []
is_obsolete: true
replaced_by: GO:0004525

[Term]
id: GO:0016444
name: somatic cell DNA recombination
namespace: biological_process
def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0016445
name: somatic diversification of immunoglobulins
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149]
synonym: "somatic diversification of antibodies" EXACT []
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0016446
name: somatic hypermutation of immunoglobulin genes
namespace: biological_process
def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007]
synonym: "somatic hypermutation of antibody genes" EXACT []
is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016447
name: somatic recombination of immunoglobulin gene segments
namespace: biological_process
def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of antibody gene segments" EXACT []
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016453
name: C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0016454
name: C-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016408 ! C-acyltransferase activity
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0016456
name: X chromosome located dosage compensation complex, transcription activating
namespace: cellular_component
def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mr, GOC:mtg_sensu, PMID:20622855, Wikipedia:XY_sex-determination_system]
synonym: "dosage compensation complex" BROAD []
is_a: GO:0046536 ! dosage compensation complex
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0000805 ! X chromosome

[Term]
id: GO:0016457
name: obsolete dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl]
comment: The reason for obsoletion is that this represents a GO-CAM model.
synonym: "dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0016458
name: obsolete gene silencing
namespace: biological_process
def: "OBSOLETE. Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
comment: This term was obsoleted because its definition was too broad, and not distinct from 'GO:0045814 negative regulation of gene expression, epigenetic'.
xref: Wikipedia:Gene_silencing
is_obsolete: true
consider: GO:0010629
consider: GO:0031507

[Term]
id: GO:0016459
name: myosin complex
namespace: cellular_component
def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0016460
name: myosin II complex
namespace: cellular_component
def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]
synonym: "conventional myosin" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016461
name: unconventional myosin complex
namespace: cellular_component
alt_id: GO:0005860
def: "A portmanteau term for myosins other than myosin II." [GOC:ma]
comment: Note that this term is retained because it is widely used by biologists.
synonym: "non-muscle myosin" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016462
name: pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]
xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP"
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0016463
name: P-type zinc transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out)." [RHEA:20621]
synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT []
synonym: "P(1B)-type ATPase activity" NARROW [EC:7.2.2.12]
synonym: "P1B-type ATPase activity" RELATED [EC:7.2.2.12]
synonym: "zinc exporting ATPase activity" BROAD []
synonym: "zinc transmembrane transporter activity, phosphorylative mechanism" RELATED []
synonym: "zinc-exporting ATPase activity" RELATED []
synonym: "zinc-translocating P-type ATPase activity" EXACT [EC:7.2.2.12]
synonym: "Zn(2+)-exporting ATPase activity" RELATED [EC:7.2.2.12]
synonym: "Zn2+-exporting ATPase activity" RELATED [EC:7.2.2.12]
xref: EC:7.2.2.12
xref: MetaCyc:RXN0-5205
xref: RHEA:20621
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0016464
name: chloroplast protein-transporting ATPase activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:7.4.2.4]
synonym: "AAA chloroplast protein-transporting ATPase" EXACT []
synonym: "ATPase-coupled chloroplast protein transporter activity" EXACT []
xref: EC:7.4.2.4
xref: MetaCyc:3.6.3.52-RXN
is_a: GO:0015450 ! protein-transporting ATPase activity

[Term]
id: GO:0016465
name: chaperonin ATPase complex
namespace: cellular_component
def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [PMID:24816391]
is_a: GO:0101031 ! protein folding chaperone complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0016466
name: obsolete hydrogen-translocating A-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "hydrogen-translocating A-type ATPase activity" EXACT []
synonym: "proton-translocating A-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046961

[Term]
id: GO:0016467
name: obsolete hydrogen-translocating F-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP synthase" BROAD []
synonym: "F1-ATPase activity" EXACT []
synonym: "hydrogen-translocating F-type ATPase activity" EXACT []
synonym: "proton-translocating F-type ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046933
consider: GO:0046961

[Term]
id: GO:0016468
name: obsolete sodium-translocating F-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP synthase" BROAD []
synonym: "sodium-translocating F-type ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046932
consider: GO:0046962

[Term]
id: GO:0016469
name: proton-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "hydrogen-transporting two-sector ATPase complex" EXACT []
synonym: "vacuolar hydrogen-transporting ATPase" RELATED []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0016471
name: vacuolar proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]
comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'.
synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT []
is_a: GO:0033176 ! proton-transporting V-type ATPase complex
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0016472
name: sodium ion-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431]
subset: goslim_pir
synonym: "sodium-transporting two-sector ATPase complex" EXACT []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0016473
name: sodium ion-transporting F-type ATPase complex
namespace: cellular_component
def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431]
synonym: "sodium-translocating F-type ATPase complex" EXACT []
is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex

[Term]
id: GO:0016474
name: sodium ion-transporting V-type ATPase complex
namespace: cellular_component
def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565]
synonym: "sodium-translocating V-type ATPase complex" EXACT []
is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex

[Term]
id: GO:0016475
name: detection of nuclear:cytoplasmic ratio
namespace: biological_process
def: "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl]
synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT []
synonym: "sensing of nuclear:cytoplasmic ratio" EXACT []
is_a: GO:0071495 ! cellular response to endogenous stimulus
relationship: part_of GO:0016049 ! cell growth

[Term]
id: GO:0016476
name: regulation of embryonic cell shape
namespace: biological_process
def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008360 ! regulation of cell shape
is_a: GO:0045995 ! regulation of embryonic development

[Term]
id: GO:0016477
name: cell migration
namespace: biological_process
def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
xref: Wikipedia:Cell_migration
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0016479
name: negative regulation of transcription by RNA polymerase I
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW []
synonym: "negative regulation of transcription from Pol I promoter" EXACT []
synonym: "negative regulation of transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0006356 ! regulation of transcription by RNA polymerase I
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
relationship: negatively_regulates GO:0006360 ! transcription by RNA polymerase I

[Term]
id: GO:0016480
name: negative regulation of transcription by RNA polymerase III
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW []
synonym: "negative regulation of transcription from Pol III promoter" EXACT []
synonym: "negative regulation of transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0006359 ! regulation of transcription by RNA polymerase III
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
relationship: negatively_regulates GO:0006383 ! transcription by RNA polymerase III

[Term]
id: GO:0016482
name: cytosolic transport
namespace: biological_process
def: "The directed movement of substances or organelles within the cytosol." [GOC:ai]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0016483
name: tryptophan hydroxylase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0016484
name: obsolete proprotein convertase 2 activator activity
namespace: molecular_function
def: "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "proprotein convertase 2 activator activity" EXACT []
is_obsolete: true
consider: GO:0016504

[Term]
id: GO:0016485
name: protein processing
namespace: biological_process
alt_id: GO:0051605
def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
subset: goslim_chembl
synonym: "peptidolysis during protein maturation" RELATED [GOC:mah]
synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf]
synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah]
synonym: "protein maturation by proteolysis" RELATED [GOC:mah]
is_a: GO:0006508 ! proteolysis
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0016486
name: peptide hormone processing
namespace: biological_process
def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah]
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0140448 ! signaling receptor ligand precursor processing

[Term]
id: GO:0016487
name: farnesol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]
synonym: "farnesol metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0016488
name: farnesol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]
synonym: "farnesol breakdown" EXACT []
synonym: "farnesol catabolism" EXACT []
synonym: "farnesol degradation" EXACT []
is_a: GO:0016095 ! polyprenol catabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0016487 ! farnesol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process

[Term]
id: GO:0016490
name: structural constituent of peritrophic membrane
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "structural constituent of peritrophic matrix" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0016491
name: oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "oxidoreductase activity, acting on other substrates" NARROW []
synonym: "redox activity" EXACT []
xref: EC:1.-.-.-
xref: Reactome:R-HSA-1614362 "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases"
xref: Reactome:R-HSA-209921 "Monoiodinated tyrosine can be deiodinated"
xref: Reactome:R-HSA-209960 "Diiodinated tyrosine can be deiodinated"
xref: Reactome:R-HSA-2161612 "PGH2 is reduced to PGF2a by FAM213B"
xref: Reactome:R-HSA-265296 "Arachidonate is oxidised to 5S-HpETE by ALOX5"
xref: Reactome:R-HSA-266051 "5S-HpETE is dehydrated to LTA4 by ALOX5"
xref: Reactome:R-HSA-390425 "FAR1 reduces PalmCoA to HXOL"
xref: Reactome:R-HSA-390438 "FAR2 reduces PalmCoA to HXOL"
xref: Reactome:R-HSA-5662660 "Dopachrome is transformed to DHICA by DCT"
xref: Reactome:R-HSA-8878581 "TYRP1 oxidises DHICA to IQCA"
xref: Reactome:R-HSA-8936442 "MARC1,MARC2 reduce N-hydroxylated compounds"
xref: Reactome:R-HSA-9020249 "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6"
xref: Reactome:R-HSA-9020260 "Hydroperoxy reductase reduces 7(S)-Hp-17(S)-HDHA to RvD5"
xref: Reactome:R-HSA-9024624 "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6"
xref: Reactome:R-HSA-9024630 "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5"
xref: Reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1"
xref: Reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA"
xref: Reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA"
xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA"
xref: Reactome:R-HSA-9693722 "Unknown sepiapterin synthase transforms PTHP to sepiapterin"
xref: Reactome:R-HSA-9759549 "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016492
name: G protein-coupled neurotensin receptor activity
namespace: molecular_function
def: "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649]
synonym: "G protein coupled neurotensin receptor activity" EXACT []
synonym: "G-protein coupled neurotensin receptor activity" EXACT []
synonym: "neurotensin receptor activity, G protein coupled" EXACT []
synonym: "neurotensin receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0016493
name: C-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:signaling, PMID:8662823]
is_a: GO:0004950 ! chemokine receptor activity

[Term]
id: GO:0016494
name: C-X-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:signaling, PMID:8662823]
is_a: GO:0004950 ! chemokine receptor activity

[Term]
id: GO:0016495
name: C-X3-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph, GOC:signaling]
is_a: GO:0004950 ! chemokine receptor activity

[Term]
id: GO:0016496
name: substance P receptor activity
namespace: molecular_function
def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016497
name: substance K receptor activity
namespace: molecular_function
def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
synonym: "neurokinin A receptor activity" EXACT []
synonym: "neuromedin L receptor activity" EXACT []
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016498
name: neuromedin K receptor activity
namespace: molecular_function
def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
synonym: "neurokinin B receptor activity" EXACT []
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016499
name: orexin receptor activity
namespace: molecular_function
def: "Combining with orexin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0016500
name: protein-hormone receptor activity
namespace: molecular_function
def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0016501
name: prostacyclin receptor activity
namespace: molecular_function
alt_id: GO:0004959
def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGI receptor activity" RELATED []
synonym: "PGI(2) receptor activity" EXACT []
synonym: "prostaglandin I receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0016502
name: nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:signaling, ISBN:0198506732]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0016503
name: pheromone receptor activity
namespace: molecular_function
def: "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior." [GOC:hjd, ISBN:0198506732]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0016504
name: peptidase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a peptidase." [GOC:ai]
synonym: "protease activator activity" NARROW [GOC:mah]
xref: Reactome:R-HSA-168865 "NA activation of TGF-beta"
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0061134 ! peptidase regulator activity

[Term]
id: GO:0016505
name: peptidase activator activity involved in apoptotic process
namespace: molecular_function
def: "Binds to and increases the activity of a peptidase that is involved in the apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]
synonym: "apoptotic protease activator activity" NARROW []
is_a: GO:0016504 ! peptidase activator activity

[Term]
id: GO:0016506
name: obsolete apoptosis activator activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "apoptosis activator activity" EXACT []
is_obsolete: true
replaced_by: GO:0006915

[Term]
id: GO:0016507
name: mitochondrial fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def: "A multienzyme complex possessing three activities in two subunits (alpha and beta) that catalyzes three steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. The alpha subunit comprises the enoyl-CoA hydratase (ECH) and 3-hydroxyacyl-CoA dehydrogenase (HACD) activities, and the beta subunit contains the acetyl-CoA C-acyltransferase (KACT)/thiolase activity." [GOC:sjm, PMID:29915090]
synonym: "fatty acid beta-oxidation multienzyme complex" BROAD [GOC:imk]
synonym: "trifunctional enzyme" RELATED []
is_a: GO:0036125 ! fatty acid beta-oxidation multienzyme complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0016508
name: obsolete long-chain-enoyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
is_obsolete: true
replaced_by: GO:0018812

[Term]
id: GO:0016509
name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD+ = a long-chain 3-oxo-fatty acyl-CoA + H+ + NADH. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [EC:1.1.1.211, GOC:pde, RHEA:52656]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" RELATED [EC:1.1.1.211]
synonym: "LCHAD" RELATED [EC:1.1.1.211]
synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.211]
synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.211]
xref: EC:1.1.1.211
xref: MetaCyc:1.1.1.211-RXN
xref: RHEA:52656
is_a: GO:0003857 ! 3-hydroxyacyl-CoA dehydrogenase activity

[Term]
id: GO:0016511
name: obsolete endothelin-converting enzyme activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "endothelin-converting enzyme activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016512
name: obsolete endothelin-converting enzyme 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "ECE-1 activity" RELATED []
synonym: "endothelin-converting enzyme 1 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016513
name: core-binding factor complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254]
synonym: "AML1 complex" NARROW []
synonym: "CBF complex" EXACT []
synonym: "PEPB2 complex" NARROW []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0016514
name: SWI/SNF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof." [GOC:bhm, PMID:12672490]
synonym: "SWI-SNF complex" EXACT [GOC:mah]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0016515
name: interleukin-13 receptor activity
namespace: molecular_function
def: "Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-13 receptor activity" EXACT [GOC:mah]
synonym: "IL-13R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0016516
name: interleukin-4 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772]
synonym: "IL-4 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0016517
name: interleukin-12 receptor activity
namespace: molecular_function
def: "Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-12 receptor activity" EXACT [GOC:mah]
synonym: "IL-12R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0016518
name: obsolete interleukin-14 receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
synonym: "IL-14 receptor activity" EXACT [GOC:mah]
synonym: "IL-14R" EXACT []
is_obsolete: true

[Term]
id: GO:0016519
name: gastric inhibitory peptide receptor activity
namespace: molecular_function
def: "Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:mah, PMID:8243312]
synonym: "GIP receptor activity" EXACT [PMID:19251046]
synonym: "glucose-dependent insulinotropic polypeptide receptor activity" EXACT [PMID:19251046]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0016520
name: growth hormone-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0016521
name: pituitary adenylate cyclase activating polypeptide activity
namespace: molecular_function
def: "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation." [GOC:mah, PMID:19805477]
synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016524
name: latrotoxin receptor activity
namespace: molecular_function
def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling, PMID:10025961]
synonym: "latrophilin" NARROW []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0016525
name: negative regulation of angiogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]
synonym: "down regulation of angiogenesis" EXACT []
synonym: "down-regulation of angiogenesis" EXACT []
synonym: "downregulation of angiogenesis" EXACT []
synonym: "inhibition of angiogenesis" NARROW []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
relationship: negatively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0016527
name: obsolete brain-specific angiogenesis inhibitor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it is based on anatomical information, and describes at least one gene product. It has also never been defined.
synonym: "brain-specific angiogenesis inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004930

[Term]
id: GO:0016528
name: sarcoplasm
namespace: cellular_component
def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684]
xref: Wikipedia:Sarcoplasm
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0016529
name: sarcoplasmic reticulum
namespace: cellular_component
alt_id: GO:0008221
def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]
comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'.
xref: Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0016530
name: metallochaperone activity
namespace: molecular_function
def: "Binding to and delivering metal ions to a target protein." [PMID:11739376]
subset: goslim_pir
is_a: GO:0140104 ! molecular carrier activity

[Term]
id: GO:0016531
name: copper chaperone activity
namespace: molecular_function
def: "Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376]
xref: Reactome:R-HSA-9865449 "Metallochaperone inserts Cu2+ into MT-CO1"
xref: Reactome:R-HSA-9865579 "MT-CO1 and MT-CO2 complexes associate, installing heme moieties"
xref: Reactome:R-HSA-9865630 "Metallochaperone inserts 2Cu2+ into MT-CO2"
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0016532
name: superoxide dismutase copper chaperone activity
namespace: molecular_function
def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]
comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'.
is_a: GO:0016531 ! copper chaperone activity

[Term]
id: GO:0016533
name: protein kinase 5 complex
namespace: cellular_component
def: "A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent." [PMID:15689152]
synonym: "cyclin-dependent protein kinase 5 holoenzyme complex" RELATED []
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0016536
name: obsolete cyclin-dependent protein kinase 5 activator regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai]
comment: This term was made obsolete because it refers to a specific gene product.
synonym: "cyclin-dependent protein kinase 5 activator regulator activity" EXACT []
synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW []
is_obsolete: true

[Term]
id: GO:0016538
name: cyclin-dependent protein serine/threonine kinase regulator activity
namespace: molecular_function
alt_id: GO:0003751
alt_id: GO:0003752
alt_id: GO:0003753
def: "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]
synonym: "cyclin" BROAD []
synonym: "cyclin-dependent protein kinase regulator activity" BROAD []
synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW []
synonym: "G1/S-specific cyclin" NARROW []
synonym: "G2/M-specific cyclin" NARROW []
xref: Reactome:R-HSA-3215385 "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77"
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0016539
name: intein-mediated protein splicing
namespace: biological_process
def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, PMID:16305544]
synonym: "intein" RELATED []
is_a: GO:0030908 ! protein splicing

[Term]
id: GO:0016540
name: protein autoprocessing
namespace: biological_process
def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]
subset: goslim_chembl
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0016541
name: obsolete intein
namespace: molecular_function
def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123]
comment: This term was made obsolete because it refers to a protein sequence feature.
synonym: "intein" EXACT []
is_obsolete: true
consider: GO:0004519
consider: GO:0016539

[Term]
id: GO:0016543
name: male courtship behavior, orientation prior to leg tapping and wing vibration
namespace: biological_process
def: "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827]
synonym: "male courtship behavior, orientation" RELATED []
synonym: "male courtship behaviour, orientation" RELATED []
synonym: "male courtship behaviour, orientation prior to leg tapping and wing vibration" RELATED []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016544
name: male courtship behavior, tapping to detect pheromone
namespace: biological_process
def: "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, tapping" RELATED []
synonym: "male courtship behaviour, tapping" EXACT []
synonym: "male courtship behaviour, tapping to detect pheromone" RELATED []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016545
name: male courtship behavior, veined wing vibration
namespace: biological_process
def: "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, wing vibration" RELATED []
synonym: "male courtship behaviour, veined wing vibration" EXACT []
synonym: "male courtship behaviour, wing vibration" RELATED []
is_a: GO:0048065 ! male courtship behavior, veined wing extension

[Term]
id: GO:0016546
name: male courtship behavior, proboscis-mediated licking
namespace: biological_process
def: "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, licking" RELATED []
synonym: "male courtship behaviour, licking" RELATED []
synonym: "male courtship behaviour, proboscis-mediated licking" EXACT []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016550
name: obsolete insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "insertion or deletion editing" EXACT []
synonym: "insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016551
name: obsolete posttranscriptional insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "posttranscriptional insertion or deletion editing" EXACT []
synonym: "posttranscriptional insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016552
name: obsolete cotranscriptional insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "cotranscriptional insertion or deletion editing" EXACT []
synonym: "cotranscriptional insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016553
name: base conversion or substitution editing
namespace: biological_process
def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837]
synonym: "base conversion/substitution editing" EXACT []
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0016554
name: cytidine to uridine editing
namespace: biological_process
def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837]
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0016555
name: uridine to cytidine editing
namespace: biological_process
def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837]
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0016556
name: mRNA modification
namespace: biological_process
alt_id: GO:0006381
def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
synonym: "mRNA editing" NARROW [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0009451 ! RNA modification
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0016557
name: peroxisome membrane biogenesis
namespace: biological_process
def: "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah]
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0016558
name: protein import into peroxisome matrix
namespace: biological_process
def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]
synonym: "peroxisome matrix protein import" EXACT []
synonym: "protein transport to peroxisome matrix" EXACT []
is_a: GO:0015919 ! peroxisomal membrane transport
is_a: GO:0044743 ! protein transmembrane import into intracellular organelle
is_a: GO:0065002 ! intracellular protein transmembrane transport
is_a: GO:0072663 ! establishment of protein localization to peroxisome

[Term]
id: GO:0016559
name: peroxisome fission
namespace: biological_process
def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]
synonym: "peroxisome division" EXACT []
synonym: "peroxisome proliferation" EXACT []
is_a: GO:0048285 ! organelle fission
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0016560
name: protein import into peroxisome matrix, docking
namespace: biological_process
def: "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]
synonym: "peroxisome matrix protein import, docking" EXACT []
synonym: "peroxisome receptor docking" RELATED []
synonym: "protein docking during peroxisome matrix protein import" EXACT []
synonym: "protein docking during protein import into peroxisome matrix" EXACT []
synonym: "protein docking during protein transport into peroxisome matrix" EXACT []
synonym: "protein transport into peroxisome matrix, docking" EXACT []
is_a: GO:0008104 ! protein localization
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016561
name: protein import into peroxisome matrix, translocation
namespace: biological_process
def: "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502]
synonym: "peroxisome matrix protein import, translocation" EXACT []
synonym: "peroxisome receptor translocation" RELATED []
synonym: "protein translocation during peroxisome matrix protein import" EXACT []
synonym: "protein translocation during protein import into peroxisome matrix" EXACT []
synonym: "protein translocation during protein transport into peroxisome matrix" EXACT []
synonym: "protein transport into peroxisome matrix, translocation" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016562
name: protein import into peroxisome matrix, receptor recycling
namespace: biological_process
def: "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502]
synonym: "peroxisome matrix protein import, receptor recycling" EXACT []
synonym: "peroxisome receptor recycling" RELATED []
synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT []
synonym: "PTS receptor recycling" RELATED []
synonym: "receptor recycling during peroxisome matrix protein import" EXACT []
synonym: "receptor recycling during protein import into peroxisome matrix" EXACT []
synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT []
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016563
name: obsolete transcription activator activity
namespace: molecular_function
alt_id: GO:0003710
def: "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "transcription activating factor" NARROW []
synonym: "transcription activator activity" EXACT []
synonym: "transcriptional activator activity" EXACT []
is_obsolete: true
replaced_by: GO:0001228

[Term]
id: GO:0016564
name: obsolete transcription repressor activity
namespace: molecular_function
def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "negative transcriptional regulator activity" EXACT []
synonym: "transcription repressor activity" EXACT []
synonym: "transcriptional repressor activity" EXACT []
is_obsolete: true
consider: GO:0001227

[Term]
id: GO:0016565
name: obsolete general transcriptional repressor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "general transcriptional repressor activity" EXACT []
is_obsolete: true
consider: GO:0001217
consider: GO:0001227
consider: GO:0045892

[Term]
id: GO:0016566
name: obsolete specific transcriptional repressor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "specific transcriptional repressor activity" EXACT []
is_obsolete: true
consider: GO:0001217
consider: GO:0001227
consider: GO:0045892

[Term]
id: GO:0016567
name: protein ubiquitination
namespace: biological_process
def: "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419]
synonym: "protein ubiquitinylation" EXACT []
synonym: "protein ubiquitylation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0016569
name: obsolete covalent chromatin modification
namespace: biological_process
def: "OBSOLETE. The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "chromatin modification" EXACT []
is_obsolete: true

[Term]
id: GO:0016570
name: obsolete histone modification
namespace: biological_process
def: "OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]
comment: This term was obsoleted because it represents a molecular function.
xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation
is_obsolete: true

[Term]
id: GO:0016571
name: obsolete histone methylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
xref: Wikipedia:Histone_methylation
is_obsolete: true

[Term]
id: GO:0016572
name: obsolete histone phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by addition of phosphate groups." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0016573
name: obsolete histone acetylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0016574
name: obsolete histone ubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone ubiquitinylation" EXACT []
synonym: "histone ubiquitylation" EXACT []
is_obsolete: true

[Term]
id: GO:0016575
name: obsolete histone deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0016576
name: obsolete histone dephosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by removal of phosphate groups." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0140789

[Term]
id: GO:0016577
name: obsolete histone demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by removal of methyl groups." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0016578
name: obsolete histone deubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histones by removal of ubiquitin groups." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone deubiquitinylation" EXACT []
synonym: "histone deubiquitylation" EXACT []
is_obsolete: true

[Term]
id: GO:0016579
name: protein deubiquitination
namespace: biological_process
alt_id: GO:0006514
def: "The removal of one or more ubiquitin groups from a protein." [GOC:ai]
synonym: "deubiquitination" EXACT []
synonym: "protein deubiquitinylation" EXACT []
synonym: "protein deubiquitylation" EXACT []
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0016580
name: obsolete Sin3 complex
namespace: cellular_component
def: "OBSOLETE. A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422]
comment: This term was added in error and is ambiguous.
is_obsolete: true
replaced_by: GO:0070822

[Term]
id: GO:0016581
name: NuRD complex
namespace: cellular_component
def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]
synonym: "Mi-2 complex" NARROW []
synonym: "NRD complex" EXACT []
synonym: "nucleosome remodeling and histone deacetylation complex" EXACT []
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0005667 ! transcription regulator complex
is_a: GO:0090545 ! CHD-type complex

[Term]
id: GO:0016582
name: obsolete non-covalent chromatin modification
namespace: biological_process
def: "OBSOLETE. The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl, GOC:vw]
comment: This term was made obsolete because it was added in error; its usefulness is unclear.
is_obsolete: true

[Term]
id: GO:0016583
name: obsolete nucleosome modeling
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it has been replaced by more specific terms.
synonym: "nucleosome modeling" EXACT []
is_obsolete: true
consider: GO:0006334

[Term]
id: GO:0016584
name: obsolete nucleosome positioning
namespace: biological_process
def: "OBSOLETE. Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389]
comment: This term was obsoleted because it represents a molecular function.
synonym: "nucleosome spacing" EXACT []
is_obsolete: true
consider: GO:0140658
consider: GO:0140750
consider: GO:0140751

[Term]
id: GO:0016585
name: obsolete chromatin remodeling complex
namespace: cellular_component
alt_id: GO:0005679
def: "OBSOLETE. Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah]
comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge.
synonym: "chromatin remodeling complex" EXACT []
synonym: "chromatin remodelling complex" EXACT []
synonym: "nucleosome remodeling complex" EXACT []
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:0016586
name: RSC-type complex
namespace: cellular_component
alt_id: GO:0070604
def: "A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231]
synonym: "PBAF complex" EXACT []
synonym: "Polybromo- and BAF containing complex" EXACT [CORUM:565]
synonym: "SWI/SNF complex B" EXACT [CORUM:565]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0016587
name: Isw1 complex
namespace: cellular_component
def: "A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0016589
name: NURF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]
synonym: "nucleosome remodeling factor complex" EXACT []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0016590
name: ACF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179]
synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0016591
name: RNA polymerase II, holoenzyme
namespace: cellular_component
def: "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii]
subset: goslim_pir
synonym: "DNA-directed RNA polymerase II, holoenzyme" EXACT []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0016592
name: mediator complex
namespace: cellular_component
alt_id: GO:0000119
def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
synonym: "CDK8-containing TRAP/mediator complex" RELATED []
synonym: "L mediator complex" EXACT []
synonym: "Srb-mediator complex" EXACT [GOC:mah]
synonym: "TRAP complex" NARROW []
xref: Wikipedia:Mediator_(coactivator)
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0016593
name: Cdc73/Paf1 complex
namespace: cellular_component
def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]
synonym: "Paf1 complex" EXACT [GOC:cjk]
synonym: "Paf1p complex" EXACT [GOC:cjk]
is_a: GO:0008023 ! transcription elongation factor complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0016594
name: glycine binding
namespace: molecular_function
def: "Binding to glycine, aminoethanoic acid." [GOC:ai]
synonym: "aminoacetic acid binding" EXACT []
synonym: "aminoethanoic acid binding" EXACT []
synonym: "Gly binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0016595
name: glutamate binding
namespace: molecular_function
def: "Binding to glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai]
synonym: "glutamic acid binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0016596
name: thienylcyclohexylpiperidine binding
namespace: molecular_function
def: "Binding to thienylcyclohexylpiperidine." [GOC:jl]
synonym: "TCP binding" BROAD []
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0016597
name: amino acid binding
namespace: molecular_function
def: "Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
subset: goslim_metagenomics
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0016598
name: protein arginylation
namespace: biological_process
alt_id: GO:0019130
def: "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid arginylation" EXACT []
is_a: GO:0036211 ! protein modification process
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0016600
name: flotillin complex
namespace: cellular_component
def: "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709]
comment: See also the cellular component term 'caveola ; GO:0005901'.
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0016601
name: Rac protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal." [GOC:bf]
synonym: "Rac mediated signal transduction" EXACT []
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0016602
name: CCAAT-binding factor complex
namespace: cellular_component
def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]
synonym: "CBF complex" RELATED [GOC:bhm]
synonym: "NF-Y transcription factor complex" RELATED [GOC:bhm]
synonym: "nuclear transcription factor Y complex" RELATED [GOC:bhm]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0016603
name: glutaminyl-peptide cyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+." [RHEA:23652]
synonym: "glutaminyl cyclase activity" RELATED [EC:2.3.2.5]
synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" RELATED [EC:2.3.2.5]
synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5]
synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" RELATED [EC:2.3.2.5]
xref: EC:2.3.2.5
xref: MetaCyc:RXN-19145
xref: RHEA:23652
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0016604
name: nuclear body
namespace: cellular_component
def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]
xref: NIF_Subcellular:sao505137457
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0016605
name: PML body
namespace: cellular_component
def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585]
synonym: "ND10" EXACT []
synonym: "nuclear dot" RELATED []
synonym: "PML NB" EXACT []
synonym: "PML nuclear body" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016606
name: LYSP100-associated nuclear domain
namespace: cellular_component
def: "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863]
synonym: "LANDs" EXACT [PMID:8695863]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016607
name: nuclear speck
namespace: cellular_component
def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640]
synonym: "nuclear speckle" EXACT []
synonym: "nuclear speckles" EXACT []
synonym: "speckle domain" NARROW []
synonym: "speckle focus" RELATED []
synonym: "splicing speckle" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016608
name: growth hormone-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732]
synonym: "GHRF activity" EXACT [ISBN:0198506732]
synonym: "GHRH activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016610
name: nitrogenase complex
namespace: cellular_component
def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [PMID:10852721]
subset: goslim_pir
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0016611
name: iron-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [GOC:jl, PMID:11848850]
comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells.
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016612
name: molybdenum-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [PMID:11566366]
synonym: "molybdenum-iron nitrogenase activity" RELATED []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016613
name: vanadium-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [PMID:3474027]
synonym: "vanadium-iron nitrogenase activity" RELATED []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016614
name: oxidoreductase activity, acting on CH-OH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW []
xref: EC:1.1.-.-
xref: Reactome:R-HSA-1500781 "Fgd1 reactivates F420"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016615
name: malate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016616
name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-]
xref: EC:1.1.1.-
xref: Reactome:R-HSA-9027625 "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3"
xref: Reactome:R-HSA-9027631 "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA"
xref: Reactome:R-HSA-9027632 "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA"
xref: Reactome:R-HSA-975629 "RDH11 reduces RBP2:atRAL to RBP2:atROL"
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016617
name: 4-oxoproline reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104]
synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.104]
synonym: "hydroxy-L-proline oxidase activity" EXACT []
synonym: "hydroxyproline oxidase activity" RELATED [EC:1.1.1.104]
xref: EC:1.1.1.104
xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN
xref: RHEA:13601
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016618
name: hydroxypyruvate reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+." [EC:1.1.1.81]
synonym: "beta-hydroxypyruvate reductase activity" RELATED [EC:1.1.1.81]
synonym: "D-glycerate dehydrogenase activity" RELATED [EC:1.1.1.81]
synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.81]
synonym: "hydroxypyruvate reductase activity" BROAD []
synonym: "NADH:hydroxypyruvate reductase activity" RELATED [EC:1.1.1.81]
xref: EC:1.1.1.81
xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016620
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.2.1.-
xref: Reactome:R-HSA-1222583 "MscR reduces nitrosomycothiol to ammonia"
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016621
name: cinnamoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44]
synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" RELATED [EC:1.2.1.44]
synonym: "cinnamoyl CoA reductase activity" EXACT []
synonym: "cinnamoyl-CoA:NADPH reductase activity" RELATED [EC:1.2.1.44]
synonym: "cinnamoyl-coenzyme A reductase activity" RELATED [EC:1.2.1.44]
synonym: "feruloyl coenzyme A reductase activity" RELATED [EC:1.2.1.44]
synonym: "feruloyl-CoA reductase activity" RELATED [EC:1.2.1.44]
synonym: "ferulyl-CoA reductase activity" RELATED [EC:1.2.1.44]
synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" RELATED [EC:1.2.1.44]
xref: EC:1.2.1.44
xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN
xref: RHEA:10620
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016622
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
xref: EC:1.2.2.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016623
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [EC:1.2.3.-]
xref: EC:1.2.3.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016624
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT []
xref: EC:1.2.4.-
xref: Reactome:R-HSA-9858321 "DHTKD1 dimer decarboxylates 2-OA"
xref: Reactome:R-HSA-9859148 "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV"
xref: Reactome:R-HSA-9865121 "BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA"
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016625
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.2.7.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016626
name: obsolete oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016903

[Term]
id: GO:0016627
name: oxidoreductase activity, acting on the CH-CH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.3.-.-]
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW []
xref: EC:1.3.-.-
xref: Reactome:R-HSA-2995334 "COX15 transforms heme O to heme A"
xref: Reactome:R-HSA-9661710 "An unknown oxidase oxidises D-UBGN to UBN"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016628
name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [EC:1.3.1.-]
xref: EC:1.3.1.-
xref: Reactome:R-HSA-4419979 "SRD5A3 reduces pPNOL to DCHOL"
xref: Reactome:R-HSA-4755572 "Defective SRD5A3 does not reduce pPNOL to DCHOL"
xref: Reactome:R-HSA-9661726 "An unknown reductase reduces D-UBGN to STBN"
xref: Reactome:R-HSA-9661745 "An unknown BILR reduces BIL to D-UBGN"
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016629
name: 12-oxophytodienoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + H+ + NADPH." [EC:1.3.1.42, RHEA:21888]
synonym: "12-oxo-phytodienoate reductase activity" EXACT []
synonym: "12-oxo-phytodienoic acid reductase activity" RELATED [EC:1.3.1.42]
synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" RELATED [EC:1.3.1.42]
xref: EC:1.3.1.42
xref: KEGG_REACTION:R03401
xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN
xref: RHEA:21888
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016630
name: protochlorophyllide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33]
synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" RELATED [EC:1.3.1.33]
synonym: "NADPH-protochlorophyllide oxidoreductase activity" RELATED [EC:1.3.1.33]
synonym: "NADPH-protochlorophyllide reductase activity" RELATED [EC:1.3.1.33]
synonym: "NADPH2-protochlorophyllide oxidoreductase activity" RELATED [EC:1.3.1.33]
synonym: "protochlorophyllide oxidoreductase activity" RELATED [EC:1.3.1.33]
synonym: "protochlorophyllide photooxidoreductase activity" RELATED [EC:1.3.1.33]
xref: EC:1.3.1.33
xref: MetaCyc:RXN1F-10
xref: RHEA:11132
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016631
name: enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [GOC:rb]
comment: This term should not be used for direct annotation; please use of the children that specifies the cofactor of the reaction (NAD+ or NADP+): enoyl-[acyl-carrier-protein] reductase (NADH) activity ; GO:0004318 or enoyl-[acyl-carrier-protein] reductase (NADPH) activity ; GO:0141148.
subset: gocheck_do_not_annotate
synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT []
synonym: "enoyl-[acyl-carrier-protein] reductase activity" BROAD []
synonym: "enoyl-ACP reductase activity" EXACT []
synonym: "enoyl-acyl carrier protein reductase" EXACT []
xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016632
name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [EC:1.3.2.-]
xref: EC:1.3.2.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016633
name: galactonolactone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3]
synonym: "GLDase activity" RELATED [EC:1.3.2.3]
synonym: "GLDHase activity" RELATED [EC:1.3.2.3]
synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT []
synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.3.2.3]
synonym: "L-galactono-gamma-lactone dehydrogenase activity" RELATED [EC:1.3.2.3]
synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.3.2.3]
synonym: "L-galactonolactone dehydrogenase activity" RELATED [EC:1.3.2.3]
xref: EC:1.3.2.3
xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN
xref: RHEA:32367
is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor

[Term]
id: GO:0016634
name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [EC:1.3.3.-]
xref: EC:1.3.3.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016635
name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [EC:1.3.5.-]
xref: EC:1.3.5.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016636
name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [EC:1.3.7.-]
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.3.7.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016637
name: obsolete oxidoreductase activity, acting on the CH-CH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016627

[Term]
id: GO:0016638
name: oxidoreductase activity, acting on the CH-NH2 group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.4.-.-, GOC:ai]
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW []
xref: EC:1.4.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016639
name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
xref: EC:1.4.1.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016640
name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]
xref: EC:1.4.2.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016641
name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
xref: EC:1.4.3.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016642
name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT []
xref: EC:1.4.4.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016643
name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai]
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.4.7.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016644
name: obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016638

[Term]
id: GO:0016645
name: oxidoreductase activity, acting on the CH-NH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW []
xref: EC:1.5.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016646
name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.5.1.-
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016647
name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
xref: EC:1.5.3.-
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016648
name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT []
xref: EC:1.5.4.-
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016649
name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl]
xref: EC:1.5.5.-
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016650
name: obsolete oxidoreductase activity, acting on the CH-NH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016645

[Term]
id: GO:0016651
name: oxidoreductase activity, acting on NAD(P)H
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "NAD(P)H dehydrogenase" NARROW []
synonym: "oxidoreductase activity, acting on NADH or NADPH" RELATED []
synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW []
xref: EC:1.6.-.-
xref: Reactome:R-HSA-109343 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:R-HSA-8956458 "RNLS:FAD oxidises dh-beta-NAD to NAD+"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016652
name: oxidoreductase activity, acting on NAD(P)H as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.6.1.-]
synonym: "oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor" RELATED []
xref: EC:1.6.1.-
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0016653
name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai]
synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor" RELATED []
xref: EC:1.6.2.-
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0016655
name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]
synonym: "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" RELATED []
xref: EC:1.6.5.-
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0016656
name: monodehydroascorbate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4]
synonym: "AFR" RELATED [EC:1.6.5.4]
synonym: "AFR-reductase activity" RELATED [EC:1.6.5.4]
synonym: "ascorbate free radical reductase activity" RELATED [EC:1.6.5.4]
synonym: "ascorbate free-radical reductase activity" RELATED [EC:1.6.5.4]
synonym: "ascorbic free radical reductase activity" RELATED [EC:1.6.5.4]
synonym: "MDAsA reductase (NADPH)" RELATED [EC:1.6.5.4]
synonym: "MDHA" RELATED [EC:1.6.5.4]
synonym: "monodehydroascorbate reductase activity" EXACT []
synonym: "NADH-semidehydroascorbate oxidoreductase activity" RELATED [EC:1.6.5.4]
synonym: "NADH:AFR oxidoreductase activity" RELATED [EC:1.6.5.4]
synonym: "NADH:ascorbate radical oxidoreductase activity" RELATED [EC:1.6.5.4]
synonym: "NADH:monodehydroascorbate oxidoreductase activity" RELATED [EC:1.6.5.4]
synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" RELATED [EC:1.6.5.4]
synonym: "SDA reductase activity" RELATED [EC:1.6.5.4]
synonym: "semidehydroascorbate reductase activity" RELATED [EC:1.6.5.4]
xref: EC:1.6.5.4
xref: MetaCyc:1.6.5.4-RXN
xref: RHEA:14581
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0016657
name: obsolete oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai]
comment: The reason for obsoletion is that this term was an unnecessary grouping term that has been obsoleted by EC.
synonym: "oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor" RELATED []
is_obsolete: true

[Term]
id: GO:0016658
name: obsolete oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it.
synonym: "oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor" EXACT []
is_obsolete: true
consider: GO:0008752
consider: GO:0042602

[Term]
id: GO:0016659
name: obsolete oxidoreductase activity, acting on NADH or NADPH, other acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" EXACT []
is_obsolete: true
consider: GO:0016651

[Term]
id: GO:0016661
name: oxidoreductase activity, acting on other nitrogenous compounds as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.7.-.-]
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW []
xref: EC:1.7.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016662
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
xref: EC:1.7.2.-
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016663
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
xref: EC:1.7.3.-
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016664
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [EC:1.7.7.-]
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.7.7.-
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016665
name: obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016661

[Term]
id: GO:0016667
name: oxidoreductase activity, acting on a sulfur group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW []
synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT []
xref: EC:1.8.-.-
xref: Reactome:R-HSA-2213240 "Reduction of disulphide bonds in MHC II antigens"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016668
name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
namespace: molecular_function
alt_id: GO:0016654
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
synonym: "oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor" RELATED []
synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT []
xref: EC:1.8.1.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016669
name: oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT []
xref: EC:1.8.2.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016670
name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT []
xref: EC:1.8.3.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016671
name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]
synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT []
xref: EC:1.8.4.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016672
name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl]
synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT []
xref: EC:1.8.5.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016673
name: oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.8.7.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016674
name: obsolete oxidoreductase activity, acting on sulfur group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" EXACT []
synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016667

[Term]
id: GO:0016675
name: oxidoreductase activity, acting on a heme group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on haem group of donors" EXACT []
synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW []
xref: EC:1.9.-.-
xref: Reactome:R-HSA-5340226 "CYGB dioxygenates NO"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016676
name: obsolete oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
comment: This term was obsoleted because Enzyme Commission (EC) has rehoused all its descendant classes, and this is now a grouping term with not children.
synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT []
is_obsolete: true

[Term]
id: GO:0016677
name: oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl]
synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT []
xref: EC:1.9.6.-
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors

[Term]
id: GO:0016678
name: obsolete oxidoreductase activity, acting on heme group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT []
synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016675

[Term]
id: GO:0016679
name: oxidoreductase activity, acting on diphenols and related substances as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW []
xref: EC:1.10.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016680
name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.10.1.-
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016681
name: obsolete oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
comment: This term was obsoleted because the EC it represented was obsoleted.
is_obsolete: true

[Term]
id: GO:0016682
name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
synonym: "laccase activity" RELATED [GOC:jh]
xref: EC:1.10.3.-
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016683
name: obsolete oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016679

[Term]
id: GO:0016684
name: oxidoreductase activity, acting on peroxide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [EC:1.11.-.-]
xref: EC:1.11.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016688
name: L-ascorbate peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O." [EC:1.11.1.11]
synonym: "ascorbate peroxidase activity" RELATED [EC:1.11.1.11]
synonym: "ascorbic acid peroxidase activity" RELATED [EC:1.11.1.11]
synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.11]
synonym: "L-ascorbic acid peroxidase activity" RELATED [EC:1.11.1.11]
synonym: "L-ascorbic acid-specific peroxidase activity" RELATED [EC:1.11.1.11]
xref: EC:1.11.1.11
xref: MetaCyc:RXN-12440
xref: RHEA:22996
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016689
name: manganese peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O." [EC:1.11.1.13]
synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.13]
synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" RELATED [EC:1.11.1.13]
synonym: "Mn-dependent peroxidase activity" RELATED [EC:1.11.1.13]
synonym: "peroxidase-M2" RELATED [EC:1.11.1.13]
xref: EC:1.11.1.13
xref: MetaCyc:MANGANESE-PEROXIDASE-RXN
xref: RHEA:22776
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016690
name: diarylpropane peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O." [EC:1.11.1.14]
synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.14]
synonym: "diarylpropane oxygenase activity" RELATED [EC:1.11.1.14]
synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" RELATED [EC:1.11.1.14]
synonym: "lignin peroxidase activity" RELATED [EC:1.11.1.14]
synonym: "ligninase activity" RELATED [EC:1.11.1.14]
synonym: "ligninase I activity" NARROW [EC:1.11.1.14]
synonym: "LiP activity" NARROW [EC:1.11.1.14]
xref: EC:1.11.1.14
xref: MetaCyc:RXN-17136
xref: RHEA:30271
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016691
name: chloride peroxidase activity
namespace: molecular_function
alt_id: GO:0016955
alt_id: GO:0016956
alt_id: GO:0016957
alt_id: GO:0016958
def: "Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O." [EC:1.11.1.10]
synonym: "chloride:hydrogen-peroxide oxidoreductase" RELATED [EC:1.11.1.10]
synonym: "chloroperoxidase activity" RELATED [EC:1.11.1.10]
synonym: "cofactor-free chloroperoxidase activity" NARROW []
synonym: "flavin-haem chloroperoxidase activity" NARROW []
synonym: "flavin-heme chloroperoxidase activity" NARROW []
synonym: "haem chloroperoxidase activity" NARROW []
synonym: "heme chloroperoxidase activity" NARROW []
synonym: "vanadium chloroperoxidase activity" NARROW []
xref: EC:1.11.1.10
xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN
is_a: GO:0140905 ! haloperoxidase activity

[Term]
id: GO:0016692
name: NADH peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O2 + NADH + H+ = 2 H2O + NAD+." [EC:1.11.1.1, RHEA:18509]
synonym: "diphosphopyridine nucleotide peroxidase activity" RELATED [EC:1.11.1.1]
synonym: "DPNH peroxidase activity" RELATED [EC:1.11.1.1]
synonym: "NAD peroxidase activity" RELATED [EC:1.11.1.1]
synonym: "NADH-peroxidase activity" RELATED [EC:1.11.1.1]
synonym: "NADH:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.1]
synonym: "nicotinamide adenine dinucleotide peroxidase activity" RELATED [EC:1.11.1.1]
xref: EC:1.11.1.1
xref: KEGG_REACTION:R00090
xref: MetaCyc:NADH-PEROXIDASE-RXN
xref: RHEA:18509
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016694
name: obsolete bacterial catalase-peroxidase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a bifunctional gene product.
synonym: "bacterial catalase-peroxidase activity" EXACT []
is_obsolete: true
consider: GO:0004096
consider: GO:0004601

[Term]
id: GO:0016695
name: oxidoreductase activity, acting on hydrogen as donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl]
synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW []
xref: EC:1.12.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016696
name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.12.1.-
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0016697
name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor
namespace: molecular_function
alt_id: GO:0016698
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl]
xref: EC:1.12.2.-
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0016699
name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
namespace: molecular_function
alt_id: GO:0016736
alt_id: GO:0019110
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl]
synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.12.7.-
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0016700
name: obsolete oxidoreductase activity, acting on hydrogen as donor, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016695

[Term]
id: GO:0016701
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [EC:1.13.-.-]
synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW []
synonym: "oxygenase" BROAD []
xref: EC:1.13.-.-
xref: Reactome:R-HSA-2161951 "Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2"
xref: Reactome:R-HSA-9018858 "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE"
xref: Reactome:R-HSA-9018859 "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE"
xref: Reactome:R-HSA-9018863 "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE"
xref: Reactome:R-HSA-9018894 "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE"
xref: Reactome:R-HSA-9020251 "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA"
xref: Reactome:R-HSA-9020255 "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA"
xref: Reactome:R-HSA-9020256 "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA"
xref: Reactome:R-HSA-9020259 "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA"
xref: Reactome:R-HSA-9020261 "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA"
xref: Reactome:R-HSA-9020264 "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA"
xref: Reactome:R-HSA-9020277 "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA"
xref: Reactome:R-HSA-9020278 "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA"
xref: Reactome:R-HSA-9020282 "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA"
xref: Reactome:R-HSA-9024997 "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA"
xref: Reactome:R-HSA-9025995 "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3"
xref: Reactome:R-HSA-9025996 "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3"
xref: Reactome:R-HSA-9025999 "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3"
xref: Reactome:R-HSA-9026005 "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA"
xref: Reactome:R-HSA-9026405 "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4"
xref: Reactome:R-HSA-9027532 "PTGS2 dimer oxidises DHA to 13-HDHA"
xref: Reactome:R-HSA-9027607 "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3"
xref: Reactome:R-HSA-9027624 "ALOX5 oxidises DHA to 7-HDHA"
xref: Reactome:R-HSA-9027627 "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)"
xref: Reactome:R-HSA-9027628 "ALOX5 oxidises EPA to 5-HEPE"
xref: Reactome:R-HSA-9027633 "ALOX5 oxidises DPAn-3 to 7-HDPAn-3"
xref: Reactome:R-HSA-9028255 "PTGS2 dimer oxidises EPA to PGH3"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016702
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]
xref: EC:1.13.11.-
xref: Reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4"
xref: Reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4"
xref: Reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4"
xref: Reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION"
xref: Reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE"
xref: Reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA"
xref: Reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3"
xref: Reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA"
xref: Reactome:R-HSA-9916401 "ALOX12 oxidises LTA4 to LXB4"
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016703
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [EC:1.13.12.-, GOC:mah]
xref: EC:1.13.12.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0016704
name: obsolete oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" EXACT []
is_obsolete: true
consider: GO:0016701

[Term]
id: GO:0016705
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [EC:1.14.-.-]
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW []
xref: EC:1.14.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016706
name: 2-oxoglutarate-dependent dioxygenase activity
namespace: molecular_function
alt_id: GO:0010302
def: "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
synonym: "2-oxoglutarate dioxygenase activity" EXACT []
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" EXACT []
xref: EC:1.14.11.-
xref: Reactome:R-HSA-1234164 "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)"
xref: Reactome:R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)"
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016707
name: gibberellin 3-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, PMID:32652020]
synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15]
synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15]
synonym: "gibberellin 3-beta-hydroxylase activity" RELATED [EC:1.14.11.15]
synonym: "gibberellin 3beta-dioxygenase activity" RELATED [EC:1.14.11.15]
synonym: "gibberellin 3beta-hydroxylase activity" RELATED [EC:1.14.11.15]
xref: EC:1.14.11.15
xref: MetaCyc:RXN1F-170
xref: RHEA:10104
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0016708
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor." [EC:1.14.12.-]
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor" RELATED []
xref: EC:1.14.12.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016709
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [EC:1.14.13.-]
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen" RELATED []
xref: EC:1.14.13.-
xref: Reactome:R-HSA-211951 "CYP1B1 4-hydroxylates EST17b"
xref: Reactome:R-HSA-2162187 "COQ6 hydroxylates DHB"
xref: Reactome:R-HSA-2162194 "COQ7:COQ9 octamer hydroxylates DMQ10H2"
xref: Reactome:R-HSA-6786239 "CYP4V2 omega-hydroxylates DHA to HDoHE"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016710
name: trans-cinnamate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.14.91]
synonym: "CA4H activity" NARROW [EC:1.14.14.91]
synonym: "cinnamate 4-hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "cinnamate 4-monooxygenase activity" RELATED [EC:1.14.14.91]
synonym: "cinnamate hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "cinnamic 4-hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "cinnamic acid 4-hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "cinnamic acid 4-monooxygenase activity" RELATED [EC:1.14.14.91]
synonym: "cinnamic acid p-hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "hydroxylase, cinnamate 4-" RELATED [EC:1.14.14.91]
synonym: "oxygenase, cinnamate 4-mono-" RELATED [EC:1.14.14.91]
synonym: "t-cinnamic acid hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "trans-cinnamate 4-hydroxylase activity" RELATED [EC:1.14.14.91]
synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.14.91]
synonym: "trans-cinnamic acid 4-hydroxylase activity" RELATED [EC:1.14.14.91]
xref: EC:1.14.14.91
xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN
xref: RHEA:10608
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0016711
name: flavonoid 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.14.82]
synonym: "flavonoid 3'-hydroxylase activity" RELATED [EC:1.14.14.82]
synonym: "flavonoid 3-hydroxylase" RELATED []
synonym: "flavonoid 3-monooxygenase" RELATED []
synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.82]
synonym: "NADPH:flavonoid-3'-hydroxylase activity" RELATED [EC:1.14.14.82]
xref: EC:1.14.14.82
xref: MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN
xref: RHEA:16337
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0016712
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
alt_id: GO:0008402
alt_id: GO:0050381
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [EC:1.14.14.-]
synonym: "aryl hydrocarbon hydroxylase activity" NARROW [EC:1.14.14.1]
synonym: "aryl-4-monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1]
synonym: "cytochrome P450 CYP19" NARROW []
synonym: "flavoprotein monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "flavoprotein-linked monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "microsomal P-450" NARROW [EC:1.14.14.1]
synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1]
synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" RELATED [EC:1.14.14.1]
synonym: "unspecific monooxygenase activity" NARROW []
synonym: "xenobiotic monooxygenase activity" NARROW [EC:1.14.14.1]
xref: EC:1.14.14.-
xref: Reactome:R-HSA-194678 "CYP51A1 demethylates LNSOL"
xref: Reactome:R-HSA-211966 "CYP2D6 4-hydroxylates debrisoquine"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016713
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [EC:1.14.15.-]
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT []
xref: EC:1.14.15.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016714
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [EC:1.14.16.-]
xref: EC:1.14.16.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016715
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [EC:1.14.17.-]
xref: EC:1.14.17.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016716
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [EC:1.14.18.-]
xref: EC:1.14.18.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016717
name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [EC:1.14.19.-]
xref: EC:1.14.19.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016718
name: obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" EXACT []
is_obsolete: true
consider: GO:0016705

[Term]
id: GO:0016719
name: 9,9'-di-cis-zeta-carotene desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol." [RHEA:30955]
synonym: "carotene 7,8-desaturase activity" RELATED []
synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" RELATED []
synonym: "zeta-carotene desaturase activity" RELATED [EC:1.3.5.6]
xref: EC:1.3.5.6
xref: MetaCyc:RXN-12242
xref: RHEA:30955
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0016720
name: acyl-lipid Delta(12)-acetylenase
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O." [RHEA:46552]
synonym: "D12-fatty acid dehydrogenase activity" EXACT []
synonym: "Delta12 fatty acid acetylenase" EXACT [EC:1.14.19.39]
synonym: "delta12-fatty acid dehydrogenase activity" RELATED []
synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT []
xref: EC:1.14.19.39
xref: KEGG_REACTION:R05740
xref: MetaCyc:1.14.99.33-RXN
xref: RHEA:46552
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0016721
name: oxidoreductase activity, acting on superoxide radicals as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai]
xref: EC:1.15.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016722
name: oxidoreductase activity, acting on metal ions
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah]
synonym: "oxidoreductase activity, oxidizing metal ions" RELATED []
synonym: "oxidoreductase activity, reducing metal ions" RELATED []
xref: EC:1.16.-.-
xref: Reactome:R-HSA-917805 "CYBRD1:Heme reduces Fe3+ to Fe2+"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016723
name: oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah]
synonym: "oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor" RELATED []
synonym: "oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor" RELATED []
xref: EC:1.16.1.-
is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions

[Term]
id: GO:0016724
name: oxidoreductase activity, acting on metal ions, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah]
synonym: "oxidoreductase activity, oxidizing metal ions, oxygen as acceptor" RELATED []
xref: EC:1.16.3.-
is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions

[Term]
id: GO:0016725
name: oxidoreductase activity, acting on CH or CH2 groups
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW []
xref: EC:1.17.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016726
name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
xref: EC:1.17.1.-
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016727
name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
xref: EC:1.17.3.-
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016728
name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]
synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT []
xref: EC:1.17.4.-
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016729
name: obsolete oxidoreductase activity, acting on CH2 groups, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on CH2 groups, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016725

[Term]
id: GO:0016730
name: oxidoreductase activity, acting on iron-sulfur proteins as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT []
xref: EC:1.18.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016731
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.18.1.-
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016732
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]
xref: EC:1.18.6.-
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016733
name: obsolete iron-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
synonym: "iron-iron nitrogenase activity" EXACT []
is_obsolete: true
consider: GO:0016163
consider: GO:0016611

[Term]
id: GO:0016734
name: obsolete molybdenum-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
synonym: "molybdenum-iron nitrogenase activity" EXACT []
is_obsolete: true
consider: GO:0016163
consider: GO:0016612

[Term]
id: GO:0016735
name: obsolete vanadium-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
synonym: "vanadium-iron nitrogenase activity" EXACT []
is_obsolete: true
consider: GO:0016163
consider: GO:0016613

[Term]
id: GO:0016737
name: oxidoreductase activity, acting on reduced flavodoxin as donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.19.-.-]
xref: EC:1.19.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016738
name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]
xref: EC:1.19.6.-
is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor

[Term]
id: GO:0016739
name: obsolete oxidoreductase activity, acting on other substrates
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on other substrates" EXACT []
is_obsolete: true
consider: GO:0016491

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: EC:2.-.-.-
xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2"
xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1"
xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK"
xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016741
name: transferase activity, transferring one-carbon groups
namespace: molecular_function
def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
synonym: "methyltransferase activity" NARROW []
xref: EC:2.1.-.-
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016742
name: hydroxymethyl-, formyl- and related transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2.-, GOC:mah]
xref: EC:2.1.2.-
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0016743
name: carboxyl- or carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]
synonym: "carboxyl- and carbamoyltransferase activity" EXACT []
xref: EC:2.1.3.-
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0016744
name: transketolase or transaldolase activity
namespace: molecular_function
alt_id: GO:0016745
def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
synonym: "transferase activity, transferring aldehyde or ketonic groups" EXACT []
xref: EC:2.2.1.-
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016746
name: acyltransferase activity
namespace: molecular_function
alt_id: GO:0008415
def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-]
subset: goslim_chembl
subset: goslim_drosophila
synonym: "transferase activity, transferring acyl groups" EXACT []
xref: EC:2.3.-.-
xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate"
xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate"
xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE"
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016747
name: acyltransferase activity, transferring groups other than amino-acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [EC:2.3.1.-]
synonym: "transferase activity, transferring acyl groups other than amino-acyl groups" EXACT []
synonym: "transferase activity, transferring groups other than amino-acyl groups" RELATED [EC:2.3.1.-]
xref: EC:2.3.1.-
xref: Reactome:R-HSA-9859163 "DBT transfers BCAA to CoA"
xref: Reactome:R-HSA-9865115 "DBT loss-of-function mutants don't synthesize BCAA-CoA"
is_a: GO:0016746 ! acyltransferase activity

[Term]
id: GO:0016748
name: succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016749
name: N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016750
name: O-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016751
name: S-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016417 ! S-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016752
name: sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0016753
name: O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016752 ! sinapoyltransferase activity

[Term]
id: GO:0016754
name: sinapoylglucose-malate O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate." [EC:2.3.1.92, RHEA:12625]
synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" RELATED [EC:2.3.1.92]
synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" RELATED [EC:2.3.1.92]
synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT []
xref: EC:2.3.1.92
xref: KEGG_REACTION:R03323
xref: MetaCyc:2.3.1.92-RXN
xref: RHEA:12625
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0016755
name: aminoacyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]
synonym: "transferase activity, transferring amino-acyl groups" EXACT []
xref: EC:2.3.2.-
is_a: GO:0016746 ! acyltransferase activity

[Term]
id: GO:0016756
name: glutathione gamma-glutamylcysteinyltransferase activity
namespace: molecular_function
alt_id: GO:0042143
def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15]
synonym: "phytochelatin synthase activity" NARROW [EC:2.3.2.15]
xref: EC:2.3.2.15
xref: MetaCyc:2.3.2.15-RXN
xref: RHEA:17917
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0016757
name: glycosyltransferase activity
namespace: molecular_function
alt_id: GO:0016932
def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "transferase activity, transferring glycosyl groups" EXACT []
synonym: "transferase activity, transferring other glycosyl groups" NARROW []
synonym: "transglycosidase activity" EXACT []
synonym: "transglycosylase activity" EXACT []
xref: EC:2.4.-.-
xref: Reactome:R-HSA-5173005 "B3GALTL transfers glucose to O-fucosyl-proteins"
xref: Reactome:R-HSA-6785565 "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins"
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016758
name: hexosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [EC:2.4.1.-]
synonym: "transferase activity, transferring hexosyl groups" EXACT []
xref: EC:2.4.1.-
is_a: GO:0016757 ! glycosyltransferase activity

[Term]
id: GO:0016759
name: cellulose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [GOC:curators]
synonym: "cellulose synthetase activity" RELATED []
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0016760
name: cellulose synthase (UDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12]
synonym: "1,4-beta-D-glucan synthase activity" RELATED [EC:2.4.1.12]
synonym: "1,4-beta-glucan synthase activity" RELATED [EC:2.4.1.12]
synonym: "beta-1,4-glucan synthase activity" RELATED [EC:2.4.1.12]
synonym: "beta-1,4-glucan synthetase activity" RELATED [EC:2.4.1.12]
synonym: "beta-1,4-glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "beta-glucan synthase activity" RELATED [EC:2.4.1.12]
synonym: "glucan synthase activity" RELATED [EC:2.4.1.12]
synonym: "GS-I" RELATED [EC:2.4.1.12]
synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "UDP-glucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "UDPglucose-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "UDPglucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12]
synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.12]
xref: EC:2.4.1.12
xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN
xref: RHEA:19929
is_a: GO:0016759 ! cellulose synthase activity
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016761
name: cellulose synthase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29]
synonym: "cellulose synthase (guanosine diphosphate-forming) activity" RELATED [EC:2.4.1.29]
synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.29]
synonym: "GDP-glucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.29]
synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.29]
synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.29]
synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.29]
synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.29]
xref: EC:2.4.1.29
xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN
xref: RHEA:17797
is_a: GO:0016759 ! cellulose synthase activity

[Term]
id: GO:0016762
name: xyloglucan:xyloglucosyl transferase activity
namespace: molecular_function
alt_id: GO:0080039
def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207, GOC:ask, PMID:1400418, PMID:1554366]
synonym: "endo-xyloglucan transferase activity" RELATED [EC:2.4.1.207]
synonym: "endoxyloglucan transferase activity" EXACT []
synonym: "xyloglucan endotransglucosylase activity" RELATED [EC:2.4.1.207]
synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" RELATED [EC:2.4.1.207]
xref: EC:2.4.1.207
xref: MetaCyc:2.4.1.207-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0016763
name: pentosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
synonym: "transferase activity, transferring pentosyl groups" EXACT []
xref: EC:2.4.2.-
xref: Reactome:R-HSA-112265 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]"
xref: Reactome:R-HSA-112266 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]"
is_a: GO:0016757 ! glycosyltransferase activity

[Term]
id: GO:0016764
name: obsolete transferase activity, transferring other glycosyl groups
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "transferase activity, transferring other glycosyl groups" EXACT []
is_obsolete: true
consider: GO:0016757

[Term]
id: GO:0016765
name: transferase activity, transferring alkyl or aryl (other than methyl) groups
namespace: molecular_function
alt_id: GO:0016766
def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [EC:2.5.1.-]
subset: goslim_chembl
subset: goslim_drosophila
synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT []
xref: EC:2.5.1.-
xref: Reactome:R-HSA-3095889 "MMACHC dealkylates RCbl"
xref: Reactome:R-HSA-4419978 "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP"
xref: Reactome:R-HSA-4755545 "Defective DHDDS does not elongate E,E-FPP"
xref: Reactome:R-HSA-6782893 "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)"
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016767
name: obsolete geranylgeranyl-diphosphate geranylgeranyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [GOC:rynl]
comment: The reason for obsoletion is that this term is a subreaction of 15-cis-phytoene synthase activity.
is_obsolete: true
replaced_by: GO:0046905

[Term]
id: GO:0016768
name: spermine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22]
synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" RELATED [EC:2.5.1.22]
synonym: "spermidine aminopropyltransferase activity" RELATED [EC:2.5.1.22]
synonym: "spermine synthetase activity" RELATED [EC:2.5.1.22]
xref: EC:2.5.1.22
xref: MetaCyc:SPERMINE-SYNTHASE-RXN
xref: Reactome:R-HSA-351210 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine"
xref: RHEA:19973
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0016769
name: transferase activity, transferring nitrogenous groups
namespace: molecular_function
def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
synonym: "transferase activity, transferring other nitrogenous groups" NARROW []
xref: EC:2.6.-.-
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016771
name: obsolete transferase activity, transferring other nitrogenous groups
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "transferase activity, transferring other nitrogenous groups" EXACT []
is_obsolete: true
consider: GO:0016769

[Term]
id: GO:0016772
name: transferase activity, transferring phosphorus-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.
subset: goslim_chembl
xref: EC:2.7.-.-
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016773
name: phosphotransferase activity, alcohol group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-]
subset: goslim_drosophila
xref: EC:2.7.1.-
xref: Reactome:R-HSA-2161193 "abacavir + AMP => abacavir monophosphate + adenosine"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016774
name: phosphotransferase activity, carboxyl group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [EC:2.7.2.-]
xref: EC:2.7.2.-
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016775
name: phosphotransferase activity, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [EC:2.7.3.-]
xref: EC:2.7.3.-
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016776
name: phosphotransferase activity, phosphate group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [EC:2.7.4.-]
xref: EC:2.7.4.-
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016778
name: diphosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, PMID:1651917]
xref: EC:2.7.6.-
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016779
name: nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor)." [EC:2.7.7.-]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_yeast
xref: EC:2.7.7.-
xref: Reactome:R-HSA-6782434 "THG1L transfers GMP to 5' end of tRNA(His)"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016780
name: phosphotransferase activity, for other substituted phosphate groups
namespace: molecular_function
def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [EC:2.7.8.-]
xref: EC:2.7.8.-
xref: Reactome:R-HSA-162742 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI"
xref: Reactome:R-HSA-163069 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016781
name: phosphotransferase activity, paired acceptors
namespace: molecular_function
def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [EC:2.7.9.-]
xref: EC:2.7.9.-
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016782
name: transferase activity, transferring sulphur-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [EC:2.8.-.-]
xref: EC:2.8.-.-
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016783
name: sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [EC:2.8.1.-, GOC:ai]
synonym: "sulphurtransferase activity" EXACT []
xref: EC:2.8.1.-
xref: Reactome:R-HSA-1614618 "Persulfide sulfur is transferred onto sulfite"
xref: Reactome:R-HSA-6782264 "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs"
xref: Reactome:R-HSA-947538 "Transfer of sulfur from MOCS3-S-S onto MOCS2A"
is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups

[Term]
id: GO:0016784
name: 3-mercaptopyruvate sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2]
synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT []
synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" RELATED [EC:2.8.1.2]
synonym: "beta-mercaptopyruvate sulfurtransferase activity" RELATED [EC:2.8.1.2]
synonym: "mercaptopyruvate sulfurtransferase activity" EXACT []
xref: EC:2.8.1.2
xref: MetaCyc:MERCAPYSTRANS-RXN
xref: Reactome:R-HSA-9012721 "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR"
xref: Reactome:R-HSA-9013471 "MPST transfers sulfur from 3MPYR to HCN to form HSCN"
xref: Reactome:R-HSA-9013533 "MPST transfers sulfur from sulfanegen to HCN to form HSCN"
xref: Reactome:R-HSA-9034756 "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST"
xref: RHEA:21740
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0016785
name: selenotransferase activity
namespace: molecular_function
alt_id: GO:0016786
def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
synonym: "transferase activity, transferring selenium-containing groups" EXACT []
xref: EC:2.9.1.-
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: EC:3.-.-.-
xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes"
xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation"
xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE"
xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB"
xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS"
xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP"
xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP"
xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016788
name: hydrolase activity, acting on ester bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl]
subset: goslim_chembl
synonym: "esterase activity" EXACT []
xref: EC:3.1.-.-
xref: Reactome:R-HSA-162729 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid"
xref: Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin"
xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin"
xref: Reactome:R-HSA-9749609 "BCHE hydrolyzes ASA-"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016790
name: thiolester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]
synonym: "thiolesterase activity" EXACT []
xref: EC:3.1.2.-
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0016791
name: phosphatase activity
namespace: molecular_function
alt_id: GO:0003869
alt_id: GO:0016302
def: "Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate." [GOC:curators, GOC:pg]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "phosphatase" RELATED []
synonym: "phosphoric monoester hydrolase activity" EXACT []
xref: EC:3.1.3.-
xref: Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL"
xref: Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P"
xref: Reactome:R-HSA-9837419 "PANK4 hydrolyzes PPANT to pantetheine"
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016793
name: triphosphoric monoester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [EC:3.1.5.-]
xref: EC:3.1.5.-
xref: Reactome:R-HSA-8866601 "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate"
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016794
name: diphosphoric monoester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a diphosphoester, releasing a diphosphate and a free hydroxyl group." [EC:3.1.7.-]
xref: EC:3.1.7.-
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016795
name: phosphoric triester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a phosphoric triester." [EC:3.1.8.-, GOC:curators]
xref: EC:3.1.8.-
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016796
name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.15.-
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0016797
name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
xref: EC:3.1.16.-
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0016798
name: hydrolase activity, acting on glycosyl bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "glycosidase activity" EXACT []
synonym: "glycosylase" NARROW []
synonym: "N-glycosylase" NARROW []
xref: EC:3.2.-.-
xref: Reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan"
xref: Reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016799
name: hydrolase activity, hydrolyzing N-glycosyl compounds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]
xref: EC:3.2.2.-
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0016801
name: hydrolase activity, acting on ether bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl]
xref: EC:3.3.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016802
name: trialkylsulfonium hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai]
synonym: "thioether hydrolase activity" EXACT []
synonym: "trialkylsulphonium hydrolase activity" EXACT []
xref: EC:3.3.1.-
is_a: GO:0016801 ! hydrolase activity, acting on ether bonds

[Term]
id: GO:0016803
name: ether hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai]
xref: EC:3.3.2.-
xref: Reactome:R-HSA-8874435 "THEM86B hydrolyses PMCHO, PMETAM"
is_a: GO:0016801 ! hydrolase activity, acting on ether bonds

[Term]
id: GO:0016804
name: obsolete prolyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5]
synonym: "Pro-X aminopeptidase activity" RELATED [EC:3.4.11.5]
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5]
synonym: "proline iminopeptidase activity" EXACT []
synonym: "prolyl aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0016805
name: dipeptidase activity
namespace: molecular_function
alt_id: GO:0102008
def: "Catalysis of the hydrolysis of a dipeptide." [EC:3.4.13.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]
synonym: "cytosolic dipeptidase activity" NARROW []
xref: EC:3.4.13.-
xref: MetaCyc:3.4.13.18-RXN
xref: Reactome:R-HSA-266012 "LTD4 is converted to LTE4 by DPEP1/2"
xref: Reactome:R-HSA-5433067 "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG"
xref: Reactome:R-HSA-5693783 "NAALADases hydrolyse NAAG"
xref: Reactome:R-HSA-9026771 "DPEP hydrolyses MCTR2 to MCTR3"
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0016806
name: obsolete dipeptidyl-peptidase and tripeptidyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai]
comment: This term was made obsolete because it represents two activities.
synonym: "dipeptidyl-peptidase and tripeptidyl-peptidase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0016807
name: cysteine-type carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]
xref: EC:3.4.18.-
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0070004 ! cysteine-type exopeptidase activity

[Term]
id: GO:0016808
name: obsolete proprotein convertase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "proprotein convertase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0016810
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [EC:3.5.-.-]
subset: goslim_chembl
subset: goslim_drosophila
synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW []
xref: EC:3.5.-.-
xref: Reactome:R-HSA-6803753 "NAAA hydrolyses NAEs to FAs and ethanolamine"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016811
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [EC:3.5.1.-]
xref: EC:3.5.1.-
xref: Reactome:R-HSA-9673053 "PM20D1 transforms oleoyl-phe from oleate and phe"
xref: Reactome:R-HSA-9673054 "PM20D1 hydrolyzes oleoyl-phe"
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016812
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [EC:3.5.2.-]
xref: EC:3.5.2.-
xref: Reactome:R-HSA-70906 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+"
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016813
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [EC:3.5.3.-]
xref: EC:3.5.3.-
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016814
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [EC:3.5.4.-]
xref: EC:3.5.4.-
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016815
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [GOC:curators]
xref: EC:3.5.5.-
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016816
name: obsolete hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" EXACT []
is_obsolete: true
consider: GO:0016810

[Term]
id: GO:0016817
name: hydrolase activity, acting on acid anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]
synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW []
xref: EC:3.6.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016818
name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]
xref: EC:3.6.1.-
xref: Reactome:R-HSA-9731590 "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP"
xref: Reactome:R-HSA-9731613 "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP"
xref: Reactome:R-HSA-9731632 "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP"
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides

[Term]
id: GO:0016819
name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai]
synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT []
xref: EC:3.6.2.-
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides

[Term]
id: GO:0016821
name: obsolete hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it incorporates process information.
synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" EXACT []
is_obsolete: true
replaced_by: GO:0016817

[Term]
id: GO:0016822
name: hydrolase activity, acting on acid carbon-carbon bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl]
xref: EC:3.7.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016823
name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [EC:3.7.1.-]
xref: EC:3.7.1.-
is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds

[Term]
id: GO:0016824
name: hydrolase activity, acting on acid halide bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid halide bond." [EC:3.8.-.-]
xref: EC:3.8.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016825
name: hydrolase activity, acting on acid phosphorus-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [EC:3.9.1.-]
xref: EC:3.9.1.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016826
name: hydrolase activity, acting on acid sulfur-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [EC:3.10.-.-]
synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT []
xref: EC:3.10.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016827
name: hydrolase activity, acting on acid carbon-phosphorus bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [EC:3.11.-.-]
xref: EC:3.11.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016828
name: hydrolase activity, acting on acid sulfur-sulfur bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [EC:3.12.-.-]
synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT []
xref: EC:3.12.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016829
name: lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
xref: EC:4.-.-.-
xref: Reactome:R-HSA-5696408 "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL"
xref: Reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016830
name: carbon-carbon lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
synonym: "other carbon-carbon lyase activity" NARROW []
xref: EC:4.1.-.-
xref: Reactome:R-HSA-189425 "UROD decarboxylates URO3 to COPRO3"
xref: Reactome:R-HSA-190182 "UROD decarboxylates URO1 to COPRO1"
xref: Reactome:R-HSA-389611 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA"
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016831
name: carboxy-lyase activity
namespace: molecular_function
def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]
synonym: "decarboxylase activity" EXACT []
xref: EC:4.1.1.-
xref: Reactome:R-HSA-6787757 "PXLP-K333-GADL1 decarboxylates acidic AAs"
xref: Reactome:R-HSA-6814165 "PXLP-K333-GADL1 decarboxylates CSA to HTAU"
xref: Reactome:R-HSA-71223 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2"
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016832
name: aldehyde-lyase activity
namespace: molecular_function
alt_id: GO:0016228
def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]
synonym: "aldolase activity" BROAD []
xref: EC:4.1.2.-
xref: Reactome:R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine"
xref: Reactome:R-HSA-200735 "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG"
xref: Reactome:R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly"
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016833
name: oxo-acid-lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3.-, GOC:jl]
synonym: "oxo-acid lyase activity" EXACT []
synonym: "oxoacid lyase activity" EXACT []
xref: EC:4.1.3.-
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016834
name: obsolete other carbon-carbon lyase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-carbon lyase activity" EXACT []
is_obsolete: true
consider: GO:0016830

[Term]
id: GO:0016835
name: carbon-oxygen lyase activity
namespace: molecular_function
def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]
synonym: "other carbon-oxygen lyase activity" NARROW []
xref: EC:4.2.-.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016836
name: hydro-lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]
xref: EC:4.2.1.-
xref: Reactome:R-HSA-2161659 "PGE2 is dehydrated to PGA2"
xref: Reactome:R-HSA-9014627 "SDS dimers:PXLP dehydrate L-Thr to 2AA"
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016837
name: carbon-oxygen lyase activity, acting on polysaccharides
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [GOC:curators]
xref: EC:4.2.2.-
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016838
name: carbon-oxygen lyase activity, acting on phosphates
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.3.-]
xref: EC:4.2.3.-
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016839
name: obsolete other carbon-oxygen lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-oxygen lyase activity" EXACT []
is_obsolete: true
consider: GO:0016835

[Term]
id: GO:0016840
name: carbon-nitrogen lyase activity
namespace: molecular_function
def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]
synonym: "other carbon-nitrogen lyase activity" NARROW []
xref: EC:4.3.-.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016841
name: ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [GOC:krc]
xref: EC:4.3.1.-
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016842
name: amidine-lyase activity
namespace: molecular_function
def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [GOC:krc]
xref: EC:4.3.2.-
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016843
name: amine-lyase activity
namespace: molecular_function
def: "Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [GOC:krc]
xref: EC:4.3.3.-
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016844
name: strictosidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine." [RHEA:15013]
synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" RELATED [EC:3.5.99.13]
synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" RELATED [EC:3.5.99.13]
synonym: "STR activity" RELATED [EC:3.5.99.13]
synonym: "strictosidine synthetase activity" RELATED [EC:3.5.99.13]
xref: EC:3.5.99.13
xref: KEGG_REACTION:R03738
xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN
xref: RHEA:15013
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016845
name: obsolete other carbon-nitrogen lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-nitrogen lyase activity" EXACT []
is_obsolete: true
consider: GO:0016840

[Term]
id: GO:0016846
name: carbon-sulfur lyase activity
namespace: molecular_function
def: "Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]
synonym: "carbon-sulphur lyase activity" EXACT []
xref: EC:4.4.-.-
xref: Reactome:R-HSA-1614567 "Excess homocysteine yields homolanthionine and H2S"
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016847
name: 1-aminocyclopropane-1-carboxylate synthase activity
namespace: molecular_function
alt_id: GO:0034100
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H+." [EC:4.4.1.14, RHEA:21744]
synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" RELATED [EC:4.4.1.14]
synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" RELATED [EC:4.4.1.14]
synonym: "1-aminocyclopropanecarboxylate synthase activity" RELATED [EC:4.4.1.14]
synonym: "ACC synthase activity" RELATED [EC:4.4.1.14]
synonym: "aminocyclopropanecarboxylate synthase activity" RELATED [EC:4.4.1.14]
synonym: "aminocyclopropanecarboxylic acid synthase activity" RELATED [EC:4.4.1.14]
synonym: "L-VG deaminase activity" RELATED [PMID:11470512]
synonym: "L-vinylglycine deaminase activity" RELATED [PMID:11470512]
synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" RELATED [EC:4.4.1.14]
synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" RELATED [EC:4.4.1.14]
xref: EC:4.4.1.14
xref: KEGG_REACTION:R00179
xref: MetaCyc:4.4.1.14-RXN
xref: RHEA:21744
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0016848
name: carbon-halide lyase activity
namespace: molecular_function
def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah]
xref: EC:4.5.-.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016849
name: phosphorus-oxygen lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
xref: EC:4.6.-.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016850
name: obsolete other lyase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other lyase activity" EXACT []
is_obsolete: true
consider: GO:0016829

[Term]
id: GO:0016851
name: magnesium chelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + Mg2+ + protoporphyrin IX = ADP + 3 H+ + Mg-protoporphyrin IX + phosphate." [RHEA:13961]
synonym: "magnesium-chelatase activity" RELATED [EC:6.6.1.1]
synonym: "magnesium-protoporphyrin chelatase activity" RELATED [EC:6.6.1.1]
synonym: "magnesium-protoporphyrin IX chelatase activity" RELATED [EC:6.6.1.1]
synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX chelatase activity" RELATED [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX magnesio-lyase activity" RELATED [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX magnesium-lyase activity" RELATED [EC:6.6.1.1]
synonym: "protoporphyrin IX magnesium-chelatase activity" RELATED [EC:6.6.1.1]
synonym: "protoporphyrin IX Mg-chelatase activity" RELATED [EC:6.6.1.1]
xref: EC:6.6.1.1
xref: KEGG_REACTION:R03877
xref: MetaCyc:RXN1F-20
xref: RHEA:13961
is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes

[Term]
id: GO:0016852
name: sirohydrochlorin cobaltochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [RHEA:15893]
synonym: "anaerobic cobalt chelatase activity" EXACT [EC:4.99.1.3]
synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" RELATED []
synonym: "cobaltochelatase" EXACT [EC:4.99.1.3]
synonym: "sirohydrochlorin cobalt-lyase activity" RELATED []
xref: EC:4.99.1.3
xref: MetaCyc:4.99.1.3-RXN
xref: RHEA:15893
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016853
name: isomerase activity
namespace: molecular_function
def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "other isomerase activity" NARROW []
xref: EC:5.-.-.-
xref: Reactome:R-HSA-2161666 "PGA2 is isomerised to PGC2"
xref: Reactome:R-HSA-2161735 "PGC2 is isomerised to PGB2"
xref: Reactome:R-HSA-6787623 "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016854
name: racemase and epimerase activity
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732]
comment: Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound.
synonym: "racemase and epimerase activity, acting on other compounds" NARROW []
xref: EC:5.1.-.-
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016855
name: racemase and epimerase activity, acting on amino acids and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah]
xref: EC:5.1.1.-
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016856
name: racemase and epimerase activity, acting on hydroxy acids and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah]
xref: EC:5.1.2.-
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016857
name: racemase and epimerase activity, acting on carbohydrates and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [EC:5.1.3.-, GOC:mah]
xref: EC:5.1.3.-
xref: Reactome:R-HSA-6787677 "FUOM isomerises alpha-Fuc to beta-Fuc"
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016858
name: obsolete racemase and epimerase activity, acting on other compounds
namespace: molecular_function
def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "racemase and epimerase activity, acting on other compounds" EXACT []
is_obsolete: true
consider: GO:0016854

[Term]
id: GO:0016859
name: cis-trans isomerase activity
namespace: molecular_function
def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732]
xref: EC:5.2.-.-
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016860
name: intramolecular oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]
synonym: "intramolecular isomerase activity" EXACT []
synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW []
xref: EC:5.3.-.-
xref: Reactome:R-HSA-109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016861
name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [EC:5.3.1.-, GOC:jl]
synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT []
xref: EC:5.3.1.-
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016862
name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [EC:5.3.2.-, GOC:jl]
synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT []
xref: EC:5.3.2.-
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016863
name: intramolecular oxidoreductase activity, transposing C=C bonds
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3.-, GOC:mah]
synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT []
xref: EC:5.3.3.-
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016864
name: intramolecular oxidoreductase activity, transposing S-S bonds
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah]
synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT []
xref: EC:5.3.4.-
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016865
name: obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases
namespace: molecular_function
def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT []
synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" EXACT []
is_obsolete: true
consider: GO:0016860

[Term]
id: GO:0016866
name: intramolecular transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]
synonym: "intramolecular transferase activity, transferring other groups" NARROW []
synonym: "mutase activity" EXACT []
xref: EC:5.4.-.-
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016867
name: intramolecular acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah]
synonym: "intramolecular transferase activity, transferring acyl groups" EXACT []
xref: EC:5.4.1.-
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016868
name: intramolecular phosphotransferase activity
namespace: molecular_function
alt_id: GO:0016777
def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]
synonym: "intramolecular transferase activity, phosphotransferases" EXACT []
synonym: "phosphomutase activity" EXACT []
synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT []
xref: EC:5.4.2.-
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016869
name: intramolecular aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah]
synonym: "intramolecular transferase activity, transferring amino groups" EXACT []
xref: EC:5.4.3.-
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016870
name: obsolete intramolecular transferase activity, transferring other groups
namespace: molecular_function
def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "intramolecular transferase activity, transferring other groups" EXACT []
is_obsolete: true
consider: GO:0016866

[Term]
id: GO:0016871
name: cycloartenol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8, RHEA:21308]
synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" RELATED [EC:5.4.99.8]
synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" RELATED [EC:5.4.99.8]
synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" RELATED [EC:5.4.99.8]
synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" RELATED [EC:5.4.99.8]
synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581]
synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" RELATED [EC:5.4.99.8]
xref: EC:5.4.99.8
xref: KEGG_REACTION:R03200
xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN
xref: RHEA:21308
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0016872
name: intramolecular lyase activity
namespace: molecular_function
def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl]
xref: EC:5.5.1.-
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016873
name: obsolete other isomerase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other isomerase activity" EXACT []
is_obsolete: true
consider: GO:0016853

[Term]
id: GO:0016874
name: ligase activity
namespace: molecular_function
def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "synthetase activity" EXACT [GOC:jh2]
xref: EC:6.-.-.-
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016875
name: ligase activity, forming carbon-oxygen bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.1.-.-]
xref: EC:6.1.-.-
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016877
name: ligase activity, forming carbon-sulfur bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.-.-]
synonym: "ligase activity, forming carbon-sulphur bonds" EXACT []
xref: EC:6.2.-.-
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016878
name: acid-thiol ligase activity
namespace: molecular_function
def: "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1.-, GOC:mah]
xref: EC:6.2.1.-
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0016879
name: ligase activity, forming carbon-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.-.-]
synonym: "other carbon-nitrogen ligase activity" NARROW []
xref: EC:6.3.-.-
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016880
name: acid-ammonia (or amide) ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
synonym: "amide synthase activity" EXACT []
xref: EC:6.3.1.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016881
name: acid-amino acid ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
synonym: "peptide synthase activity" EXACT []
xref: EC:6.3.2.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016882
name: cyclo-ligase activity
namespace: molecular_function
def: "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
xref: EC:6.3.3.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016883
name: obsolete other carbon-nitrogen ligase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-nitrogen ligase activity" EXACT []
is_obsolete: true
consider: GO:0016879

[Term]
id: GO:0016884
name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor
namespace: molecular_function
alt_id: GO:0016003
def: "Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532]
xref: EC:6.3.5.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016885
name: ligase activity, forming carbon-carbon bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-]
xref: EC:6.4.-.-
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016886
name: ligase activity, forming phosphoric ester bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5.-.-]
xref: EC:6.5.-.-
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016887
name: ATP hydrolysis activity
namespace: molecular_function
alt_id: GO:0004002
alt_id: GO:0042623
def: "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]
comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function.
synonym: "adenosine 5'-triphosphatase activity" EXACT []
synonym: "adenosine triphosphatase activity" EXACT []
synonym: "adenosinetriphosphatase activity" EXACT []
synonym: "ATP hydrolase activity" EXACT []
synonym: "ATP monophosphatase activity" RELATED []
synonym: "ATP phosphohydrolase activity" EXACT []
xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)"
xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70"
xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse"
xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90"
xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA"
xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE"
xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi"
xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER"
xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation"
xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN"
xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN"
xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane"
xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating"
xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex"
xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG"
xref: Reactome:R-HSA-917693 "ESCRT Disassembly"
xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP"
xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope"
xref: Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP"
xref: Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex"
xref: RHEA:13065
is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity
relationship: part_of GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0016888
name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.21.-
xref: Reactome:R-HSA-912368 "SPO11 hydrolyzes DNA forming double-strand breaks"
is_a: GO:0004520 ! DNA endonuclease activity
is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016889
name: DNA endonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]
synonym: "endodeoxyribonuclease activity, producing 3'-phosphomonoesters" EXACT []
synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT []
xref: EC:3.1.22.-
is_a: GO:0004520 ! DNA endonuclease activity
is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016890
name: site-specific endodeoxyribonuclease activity, specific for altered base
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl]
xref: EC:3.1.25.-
is_a: GO:0004520 ! DNA endonuclease activity

[Term]
id: GO:0016891
name: RNA endonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
synonym: "endoribonuclease activity, producing 5'-phosphomonoesters" EXACT []
xref: EC:3.1.26.-
is_a: GO:0004521 ! RNA endonuclease activity
is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016892
name: RNA endonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]
synonym: "endoribonuclease activity, producing 3'-phosphomonoesters" EXACT []
synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT []
xref: EC:3.1.27.-
xref: Reactome:R-HSA-9705961 "nsp15 cleaves viral poly(U)-RNA"
xref: Reactome:R-HSA-9755252 "nsp15 cleaves viral poly(U)-RNA"
is_a: GO:0004521 ! RNA endonuclease activity
is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016893
name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
synonym: "5'-endonuclease activity" EXACT []
synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED []
xref: EC:3.1.30.-
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0016894
name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
synonym: "3'-endonuclease activity" EXACT []
synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED []
xref: EC:3.1.31.1
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0016895
name: DNA exonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
alt_id: GO:0008858
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]
synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT []
synonym: "exonuclease VIII activity" NARROW []
xref: EC:3.1.11.-
is_a: GO:0004529 ! DNA exonuclease activity
is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016896
name: RNA exonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]
synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT []
synonym: "exoribonuclease activity, producing 5'-phosphomonoesters" EXACT []
xref: EC:3.1.13.-
xref: Reactome:R-HSA-429860 "DCP1-DCP2 complex decaps mRNA"
is_a: GO:0004532 ! RNA exonuclease activity
is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016897
name: obsolete RNA exonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "exoribonuclease activity, producing 3'-phosphomonoesters" EXACT []
is_obsolete: true

[Term]
id: GO:0016898
name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]
xref: EC:1.1.2.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016899
name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
xref: EC:1.1.3.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016900
name: obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT []
is_obsolete: true

[Term]
id: GO:0016901
name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [EC:1.1.5.-, GOC:ai]
xref: EC:1.1.5.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016902
name: obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016614

[Term]
id: GO:0016903
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW []
xref: EC:1.2.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016905
name: myosin heavy chain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" RELATED [EC:2.7.11.7]
synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" RELATED [EC:2.7.11.7]
synonym: "calmodulin-dependent myosin heavy chain kinase activity" RELATED [EC:2.7.11.7]
synonym: "MHCK" RELATED [EC:2.7.11.7]
synonym: "MIHC kinase activity" RELATED [EC:2.7.11.7]
synonym: "myosin heavy chain kinase A activity" RELATED [EC:2.7.11.7]
synonym: "myosin heavy-chain kinase activity" RELATED [EC:2.7.11.7]
synonym: "myosin I heavy chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin II heavy chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin-heavy-chain kinase activity" RELATED [EC:2.7.11.7]
synonym: "STK6" RELATED [EC:2.7.11.7]
xref: EC:2.7.11.7
xref: RHEA:11424
is_a: GO:0004683 ! calcium/calmodulin-dependent protein kinase activity

[Term]
id: GO:0016906
name: sterol 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173, RHEA:22724]
synonym: "sterol 3beta-glucosyltransferase activity" RELATED [EC:2.4.1.173]
synonym: "sterol glucosyltransferase activity" EXACT []
synonym: "sterol-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.173]
synonym: "sterol:UDPG glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" RELATED [EC:2.4.1.173]
synonym: "UDP-glucose-sterol glucosyltransferase activity" RELATED [EC:2.4.1.173]
synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.173]
synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT []
synonym: "UDPG-SGTase activity" RELATED [EC:2.4.1.173]
synonym: "UDPG:sterol glucosyltransferase activity" EXACT []
synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.173]
synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" RELATED [EC:2.4.1.173]
synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" RELATED [EC:2.4.1.173]
xref: EC:2.4.1.173
xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:22724
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016907
name: G protein-coupled acetylcholine receptor activity
namespace: molecular_function
alt_id: GO:0004981
def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]
synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled acetylcholine receptor activity" EXACT []
synonym: "G-protein coupled acetylcholine receptor activity" EXACT []
synonym: "metabotropic acetylcholine receptor activity" EXACT []
synonym: "muscarinic acetylcholine receptor activity" EXACT []
xref: Reactome:R-HSA-400012 "Acetylcholine binds Muscarinic Acetylcholine Receptor M3"
is_a: GO:0008227 ! G protein-coupled amine receptor activity
is_a: GO:0015464 ! acetylcholine receptor activity
is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity

[Term]
id: GO:0016910
name: obsolete SAP kinase 3 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a gene product.
synonym: "SAP kinase 3 activity" EXACT []
synonym: "SAPK3" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0007254

[Term]
id: GO:0016911
name: obsolete SAP kinase 4 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a gene product.
synonym: "SAP kinase 4 activity" EXACT []
synonym: "SAPK4" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0007254

[Term]
id: GO:0016912
name: obsolete SAP kinase 5 activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product.
synonym: "SAP kinase 5 activity" EXACT []
synonym: "SAPK5" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0007254

[Term]
id: GO:0016913
name: follicle-stimulating hormone activity
namespace: molecular_function
def: "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684]
synonym: "follicle stimulating hormone activity" EXACT []
synonym: "follitropin activity" EXACT [ISBN:0198506732]
synonym: "FSH activity" EXACT [GOC:mah]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016914
name: follicle-stimulating hormone complex
namespace: cellular_component
def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684]
synonym: "follicle stimulating hormone complex" EXACT []
synonym: "FSH complex" EXACT []
is_a: GO:0061696 ! pituitary gonadotropin complex

[Term]
id: GO:0016915
name: obsolete activin
namespace: molecular_function
def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
synonym: "activin" EXACT []
is_obsolete: true
consider: GO:0005160
consider: GO:0046881

[Term]
id: GO:0016916
name: obsolete inhibin
namespace: molecular_function
def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
synonym: "inhibin" EXACT []
is_obsolete: true
consider: GO:0005160
consider: GO:0046882

[Term]
id: GO:0016917
name: GABA receptor activity
namespace: molecular_function
def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650]
comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'.
synonym: "4-aminobutanoate receptor activity" EXACT []
synonym: "4-aminobutyrate receptor activity" EXACT []
synonym: "GABA binding" EXACT []
synonym: "gamma-aminobutyrate binding" EXACT []
synonym: "gamma-aminobutyric acid binding" EXACT []
synonym: "gamma-aminobutyric acid receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0016918
name: retinal binding
namespace: molecular_function
def: "Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [ISBN:0198506732]
synonym: "blue-sensitive opsin" RELATED []
synonym: "green-sensitive opsin" RELATED []
synonym: "long-wave-sensitive opsin" RELATED []
synonym: "opsin" RELATED []
synonym: "red-sensitive opsin" RELATED []
synonym: "retinaldehyde binding" EXACT []
synonym: "short-wave-sensitive opsin" RELATED []
synonym: "UV-sensitive opsin" RELATED []
synonym: "violet-sensitive opsin" RELATED []
synonym: "vitamin A binding" BROAD []
is_a: GO:0005501 ! retinoid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0016919
name: obsolete nardilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "N-arginine dibasic convertase activity" RELATED []
synonym: "nardilysin activity" EXACT []
synonym: "NRD convertase activity" RELATED []
synonym: "NRD-convertase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016920
name: pyroglutamyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [GOC:mah, PMID:9920379]
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0016921
name: obsolete pyroglutamyl-peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "pyroglutamyl-peptidase II activity" EXACT []
is_obsolete: true
consider: GO:0008237
consider: GO:0016920

[Term]
id: GO:0016922
name: nuclear receptor binding
namespace: molecular_function
alt_id: GO:0035257
alt_id: GO:0035258
def: "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]
synonym: "ligand-dependent nuclear receptor binding" EXACT []
synonym: "ligand-dependent nuclear receptor interactor activity" RELATED []
synonym: "nuclear hormone receptor binding" EXACT []
synonym: "steroid hormone receptor binding" BROAD []
is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding

[Term]
id: GO:0016923
name: obsolete ligand-dependent thyroid hormone receptor interactor activity
namespace: molecular_function
def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "ligand-dependent thyroid hormone receptor interactor activity" EXACT []
synonym: "TRIP4" RELATED []
is_obsolete: true
consider: GO:0046966

[Term]
id: GO:0016925
name: protein sumoylation
namespace: biological_process
alt_id: GO:0006485
alt_id: GO:0016927
alt_id: GO:0019947
alt_id: GO:0019951
def: "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]
synonym: "protein sumolation" EXACT []
synonym: "small ubiquitin-related protein 1 conjugation" EXACT []
synonym: "Smt3-protein conjugation" RELATED []
synonym: "Smt3p-protein conjugation" RELATED []
synonym: "SUMO-protein conjugation" EXACT []
synonym: "sumoylation" EXACT []
xref: Wikipedia:SUMO_protein
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0016926
name: protein desumoylation
namespace: biological_process
alt_id: GO:0016928
def: "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]
synonym: "desumoylation" EXACT []
synonym: "protein desumolation" EXACT []
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0016929
name: deSUMOylase activity
namespace: molecular_function
alt_id: GO:0070140
def: "An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258]
synonym: "SUMO-specific isopeptidase activity" EXACT []
synonym: "SUMO-specific protease activity" EXACT []
synonym: "SUSP" NARROW []
synonym: "ULP" NARROW []
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0019783 ! ubiquitin-like protein peptidase activity

[Term]
id: GO:0016933
name: extracellularly glycine-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "extracellular-glycine-gated ion channel activity" EXACT []
synonym: "glycine receptor" BROAD []
is_a: GO:0005231 ! excitatory extracellular ligand-gated monoatomic ion channel activity

[Term]
id: GO:0016934
name: extracellularly glycine-gated chloride channel activity
namespace: molecular_function
alt_id: GO:0004891
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "extracellular-glycine-gated chloride channel activity" EXACT []
synonym: "glycine receptor" BROAD []
synonym: "glycine-inhibited chloride channel activity" RELATED []
xref: Reactome:R-HSA-975389 "GLRA:GLRB:Gly transports extracellular Cl- to cytosol"
is_a: GO:0005237 ! inhibitory extracellular ligand-gated monoatomic ion channel activity
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0016933 ! extracellularly glycine-gated ion channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity

[Term]
id: GO:0016935
name: glycine-gated chloride channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034707 ! chloride channel complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0016936
name: galactoside binding
namespace: molecular_function
def: "Binding to a glycoside in which the sugar group is galactose." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0016937
name: short-chain fatty acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [RHEA:47196]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "butanoyl-CoA dehydrogenase" NARROW [EC:1.3.8.1]
synonym: "butyryl dehydrogenase" NARROW [EC:1.3.8.1]
synonym: "short-chain acyl CoA dehydrogenase" EXACT [EC:1.3.8.1]
synonym: "short-chain-acyl-CoA dehydrogenase activity" EXACT []
synonym: "unsaturated acyl-CoA reductase" BROAD [EC:1.3.8.1]
xref: EC:1.3.8.1
xref: KEGG_REACTION:R01178
xref: MetaCyc:RXN-13449
xref: RHEA:47196
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0016938
name: kinesin I complex
namespace: cellular_component
def: "A complex of two kinesin heavy chains and two kinesin light chains." [PMID:20930137]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016939
name: kinesin II complex
namespace: cellular_component
def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [PMID:20930137]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016941
name: natriuretic peptide receptor activity
namespace: molecular_function
def: "Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling]
is_a: GO:0001653 ! peptide receptor activity

[Term]
id: GO:0016942
name: insulin-like growth factor binding protein complex
namespace: cellular_component
def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl]
subset: goslim_pir
synonym: "IGF binding protein complex" EXACT []
is_a: GO:0036454 ! growth factor complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0016943
name: obsolete RNA polymerase I transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol I transcription elongation factor activity" EXACT []
synonym: "RNA polymerase I transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0006362

[Term]
id: GO:0016944
name: obsolete RNA polymerase II transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol II transcription elongation factor activity" EXACT []
synonym: "RNA polymerase II transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0006368

[Term]
id: GO:0016945
name: obsolete RNA polymerase III transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol III transcription elongation factor activity" EXACT []
synonym: "RNA polymerase III transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0006385

[Term]
id: GO:0016946
name: obsolete cathepsin F activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin F activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0016962
name: obsolete receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and not a molecular function.
synonym: "receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0016963
name: obsolete alpha-2 macroglobulin receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "alpha-2 macroglobulin receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0016964
name: alpha-2 macroglobulin receptor activity
namespace: molecular_function
def: "Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis." [GOC:bf, GOC:ma, PMID:6188403]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0016966
name: nitric oxide reductase activity
namespace: molecular_function
alt_id: GO:0016967
alt_id: GO:0016968
def: "Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide." [EC:1.7.2.5]
synonym: "CYP55" NARROW []
synonym: "cytochrome bc nitric oxide reductase activity" NARROW []
synonym: "nitric-oxide reductase activity" RELATED [EC:1.7.2.5]
synonym: "nitrogen oxide reductase activity" RELATED [EC:1.7.2.5]
synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" RELATED [EC:1.7.2.5]
synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" RELATED [EC:1.7.2.5]
synonym: "P450 nitric oxide reductase activity" NARROW []
synonym: "P450nor" NARROW []
xref: EC:1.7.2.5
xref: KEGG_REACTION:R00294
xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN
xref: RHEA:30211
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0016969
name: obsolete hemerythrin
namespace: molecular_function
def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "hemerythrin" EXACT []
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0016970
name: obsolete hemocyanin
namespace: molecular_function
def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "hemocyanin" EXACT []
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0016971
name: flavin-dependent sulfhydryl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins." [PMID:10899311, PMID:19679655, PMID:35495482]
synonym: "flavin-linked sulfhydryl oxidase activity" EXACT []
xref: RHEA:59116
is_a: GO:0015035 ! protein-disulfide reductase activity
is_a: GO:0016972 ! thiol oxidase activity

[Term]
id: GO:0016972
name: thiol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]
synonym: "sulfhydryl oxidase activity" RELATED [EC:1.8.3.2]
synonym: "thiol:oxygen oxidoreductase activity" RELATED [EC:1.8.3.2]
xref: EC:1.8.3.2
xref: MetaCyc:THIOL-OXIDASE-RXN
xref: RHEA:17357
xref: UM-BBD_reactionID:r1293
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0016973
name: poly(A)+ mRNA export from nucleus
namespace: biological_process
def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]
synonym: "poly(A) mRNA export from nucleus" EXACT []
synonym: "poly(A)+ mRNA export from cell nucleus" EXACT []
synonym: "poly(A)+ mRNA export out of nucleus" EXACT []
synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "poly(A)+ mRNA-nucleus export" EXACT []
synonym: "polyadenylated mRNA export from nucleus" RELATED []
is_a: GO:0006406 ! mRNA export from nucleus

[Term]
id: GO:0016975
name: obsolete alpha-2 macroglobulin
namespace: molecular_function
def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-2 macroglobulin" EXACT []
is_obsolete: true
replaced_by: GO:0004866

[Term]
id: GO:0016977
name: chitosanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132]
synonym: "chitosan N-acetylglucosaminohydrolase activity" RELATED [EC:3.2.1.132]
xref: EC:3.2.1.132
xref: MetaCyc:3.2.1.132-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016979
name: lipoate-protein ligase activity
namespace: molecular_function
alt_id: GO:0008916
alt_id: GO:0016978
alt_id: GO:0102315
def: "Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP." [PMID:16141198, PMID:17570395, RHEA:49288]
synonym: "lipoate-protein ligase A activity" NARROW []
synonym: "lipoate-protein ligase activity (lipoylation of glycine cleavage complex)" NARROW []
synonym: "lipoate-protein ligase B activity" NARROW []
xref: EC:6.3.1.20
xref: MetaCyc:RXN-17127
xref: RHEA:49288
is_a: GO:0016779 ! nucleotidyltransferase activity
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0016980
name: creatinase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatine + H2O = sarcosine + urea." [EC:3.5.3.3, RHEA:22456]
synonym: "creatine amidinohydrolase activity" RELATED [EC:3.5.3.3]
xref: EC:3.5.3.3
xref: KEGG_REACTION:R01566
xref: MetaCyc:CREATINASE-RXN
xref: RHEA:22456
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016984
name: ribulose-bisphosphate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O." [RHEA:23124]
synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39]
synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT []
synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "RuBisCO activity" EXACT [EC:4.1.1.39]
synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39]
xref: EC:4.1.1.39
xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN
xref: RHEA:23124
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0016985
name: mannan endo-1,4-beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78]
synonym: "1,4-beta-D-mannan mannanohydrolase activity" RELATED [EC:3.2.1.78]
synonym: "beta-1,4-mannan 4-mannanohydrolase activity" RELATED [EC:3.2.1.78]
synonym: "beta-D-mannanase activity" RELATED [EC:3.2.1.78]
synonym: "beta-mannanase activity" BROAD [EC:3.2.1.78]
synonym: "beta-mannanase B" RELATED [EC:3.2.1.78]
synonym: "endo-1,4-beta-mannanase activity" RELATED [EC:3.2.1.78]
synonym: "endo-1,4-mannanase activity" BROAD [EC:3.2.1.78]
synonym: "endo-beta-1,4-mannase activity" RELATED [EC:3.2.1.78]
synonym: "endo-beta-mannanase activity" BROAD [EC:3.2.1.78]
xref: EC:3.2.1.78
xref: MetaCyc:3.2.1.78-RXN
is_a: GO:0004567 ! beta-mannosidase activity

[Term]
id: GO:0016986
name: obsolete transcription initiation factor activity
namespace: molecular_function
def: "OBSOLETE. Plays a role in regulating transcription initiation." [GOC:curators]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "transcription initiation factor activity" EXACT []
synonym: "transcriptional initiation factor activity" EXACT []
is_obsolete: true
consider: GO:0140223

[Term]
id: GO:0016987
name: sigma factor activity
namespace: molecular_function
alt_id: GO:0000996
alt_id: GO:0001053
def: "Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins." [GOC:txnOH-2018]
synonym: "bacterial sigma factor activity" NARROW []
synonym: "core DNA-dependent RNA polymerase binding promoter specificity activity" EXACT []
synonym: "DNA-dependent RNA polymerase promoter selection factor" EXACT []
synonym: "plastid sigma factor activity" NARROW []
synonym: "promoter selection factor activity" NARROW []
synonym: "sigma transcription factor" EXACT []
is_a: GO:0003700 ! DNA-binding transcription factor activity

[Term]
id: GO:0016988
name: obsolete transcription initiation factor antagonist activity
namespace: molecular_function
def: "OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl]
comment: This term was obsoleted because its definition was vague and apparently broader in scope than the name of the term suggested it was intended to be.
synonym: "transcription initiation factor antagonist activity" EXACT []
synonym: "transcriptional initiation factor antagonist activity" EXACT []
is_obsolete: true

[Term]
id: GO:0016989
name: sigma factor antagonist activity
namespace: molecular_function
def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors]
synonym: "anti-sigma factor activity" EXACT []
is_a: GO:0003714 ! transcription corepressor activity

[Term]
id: GO:0016990
name: arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6]
synonym: "arginine dihydrolase activity" RELATED [EC:3.5.3.6]
synonym: "citrulline iminase activity" RELATED [EC:3.5.3.6]
synonym: "L-arginine deiminase activity" RELATED [EC:3.5.3.6]
synonym: "L-arginine iminohydrolase activity" RELATED [EC:3.5.3.6]
xref: EC:3.5.3.6
xref: MetaCyc:ARGININE-DEIMINASE-RXN
xref: RHEA:19597
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016992
name: lipoate synthase activity
namespace: molecular_function
alt_id: GO:0017140
def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109]
synonym: "LipA" RELATED [EC:2.8.1.8]
synonym: "lipoic acid synthase" EXACT [GOC:dph, GOC:tb]
synonym: "lipoyl synthase activity" RELATED [EC:2.8.1.8]
synonym: "LS" RELATED [EC:2.8.1.8]
synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" RELATED [EC:2.8.1.8]
synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" RELATED [EC:2.8.1.8]
xref: EC:2.8.1.8
xref: MetaCyc:RXN0-949
xref: Reactome:R-HSA-6793591 "LIAS synthesizes lipoyl-GCSH"
xref: RHEA:16585
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0016993
name: precorrin-8X methylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.99.61]
synonym: "HBA synthase activity" RELATED [EC:5.4.99.61]
synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.99.61]
synonym: "precorrin isomerase activity" RELATED [EC:5.4.99.61]
synonym: "precorrin-8X 11,12-methylmutase activity" EXACT []
xref: EC:5.4.99.61
xref: MetaCyc:5.4.1.2-RXN
xref: RHEA:22512
is_a: GO:0016867 ! intramolecular acyltransferase activity

[Term]
id: GO:0016994
name: precorrin-6A reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54]
synonym: "precorrin-6B:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.54]
synonym: "precorrin-6X reductase activity" EXACT []
synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" RELATED [EC:1.3.1.54]
synonym: "precorrin-6Y:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.54]
xref: EC:1.3.1.54
xref: MetaCyc:1.3.1.54-RXN
xref: RHEA:23408
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016995
name: cholesterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2." [RHEA:32183]
synonym: "3beta-hydroxy steroid oxidoreductase activity" RELATED [EC:1.1.3.6]
synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" RELATED [EC:1.1.3.6]
synonym: "cholesterol- O2 oxidoreductase activity" RELATED [EC:1.1.3.6]
synonym: "cholesterol-O2 oxidoreductase activity" RELATED [EC:1.1.3.6]
synonym: "cholesterol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.6]
xref: EC:1.1.3.6
xref: KEGG_REACTION:R01459
xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN
xref: RHEA:32183
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0016996
name: endo-alpha-(2,8)-sialidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129]
synonym: "alpha-2,8-sialosylhydrolase activity" RELATED [EC:3.2.1.129]
synonym: "endo-N-acetylneuraminidase activity" RELATED [EC:3.2.1.129]
synonym: "endo-N-acylneuraminidase activity" RELATED [EC:3.2.1.129]
synonym: "endoneuraminidase activity" RELATED [EC:3.2.1.129]
synonym: "endosialidase activity" RELATED [EC:3.2.1.129]
synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" RELATED [EC:3.2.1.129]
synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" RELATED [EC:3.2.1.129]
synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" RELATED [EC:3.2.1.129]
xref: EC:3.2.1.129
xref: MetaCyc:3.2.1.129-RXN
is_a: GO:0016997 ! alpha-sialidase activity

[Term]
id: GO:0016997
name: alpha-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016998
name: cell wall macromolecule catabolic process
namespace: biological_process
alt_id: GO:0044039
def: "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
synonym: "cell wall breakdown" RELATED [GOC:mah]
synonym: "cell wall catabolism" RELATED [GOC:mah]
synonym: "cell wall degradation" RELATED [GOC:mah]
synonym: "cellular cell wall macromolecule breakdown" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule catabolic process" EXACT []
synonym: "cellular cell wall macromolecule catabolism" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule degradation" EXACT [GOC:mah]
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0016999
name: antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
synonym: "antibiotic metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0017000
name: antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]
subset: goslim_metagenomics
synonym: "antibiotic anabolism" EXACT []
synonym: "antibiotic biosynthesis" EXACT []
synonym: "antibiotic formation" EXACT []
synonym: "antibiotic synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0016999 ! antibiotic metabolic process

[Term]
id: GO:0017001
name: antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]
synonym: "antibiotic breakdown" EXACT []
synonym: "antibiotic catabolism" EXACT []
synonym: "antibiotic degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0016999 ! antibiotic metabolic process

[Term]
id: GO:0017002
name: activin receptor activity
namespace: molecular_function
def: "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta." [GOC:mah, GOC:signaling, ISBN:0198506732]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand activin. For binding to other extracellular ligands, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "activin-activated receptor activity" EXACT []
is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity

[Term]
id: GO:0017003
name: protein-heme linkage
namespace: biological_process
def: "The covalent linkage of heme and a protein." [GOC:ma]
subset: gocheck_obsoletion_candidate
synonym: "protein-haem linkage" EXACT []
is_a: GO:0017006 ! protein-tetrapyrrole linkage

[Term]
id: GO:0017004
name: cytochrome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah]
subset: goslim_metagenomics
synonym: "cytochrome biogenesis" BROAD []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0017005
name: 3'-tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity

[Term]
id: GO:0017006
name: protein-tetrapyrrole linkage
namespace: biological_process
def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0017007
name: protein-bilin linkage
namespace: biological_process
def: "The covalent linkage of bilin and a protein." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0017006 ! protein-tetrapyrrole linkage

[Term]
id: GO:0017008
name: protein-phycobiliviolin linkage
namespace: biological_process
def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0258
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017009
name: protein-phycocyanobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0131
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017010
name: protein-phycourobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0260
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017011
name: protein-phycoerythrobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0132
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017012
name: protein-phytochromobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0133
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017013
name: protein flavinylation
namespace: biological_process
def: "The addition of a flavin group to a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid flavinylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0017014
name: protein nitrosylation
namespace: biological_process
def: "The covalent addition of a nitric oxide group to an amino acid within a protein." [GOC:ai, PMID:20972426]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid nitrosylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0017015
name: regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah]
synonym: "regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus
relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0017017
name: MAP kinase tyrosine/serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]
synonym: "dual-specificity MAP kinase phosphatase activity" EXACT []
is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity

[Term]
id: GO:0017018
name: myosin phosphatase activity
namespace: molecular_function
alt_id: GO:0017019
def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]
synonym: "myosin phosphatase myosin binding" RELATED []
synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT []
xref: Reactome:R-HSA-390593 "ATP Hydrolysis By Myosin"
xref: Reactome:R-HSA-445699 "ATP Hydrolysis By Myosin"
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0017020
name: myosin phosphatase regulator activity
namespace: molecular_function
def: "Binds to and modulates of the activity of myosin phosphatase." [GOC:ai, PMID:10491107]
synonym: "myosin phosphatase, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0017021
name: obsolete myosin phosphatase myosin binding
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function.
synonym: "myosin phosphatase myosin binding" EXACT []
is_obsolete: true
consider: GO:0017018
consider: GO:0017022

[Term]
id: GO:0017022
name: myosin binding
namespace: molecular_function
def: "Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah]
synonym: "myosin phosphatase myosin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0017023
name: myosin phosphatase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A)." [PMID:30076859]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex

[Term]
id: GO:0017024
name: myosin I binding
namespace: molecular_function
def: "Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, PMID:18344022]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0017025
name: TBP-class protein binding
namespace: molecular_function
def: "Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, PMID:1509519, PMID:16858867]
synonym: "TATA-binding protein binding" NARROW []
synonym: "TBP binding" NARROW []
synonym: "TBP-related factor (TRF) protein binding" NARROW []
is_a: GO:0140296 ! general transcription initiation factor binding

[Term]
id: GO:0017026
name: obsolete procollagen C-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "BMP1" NARROW []
synonym: "carboxyprocollagen peptidase activity" RELATED []
synonym: "procollagen C-endopeptidase activity" EXACT []
synonym: "procollagen C-proteinase activity" RELATED []
synonym: "procollagen C-terminal peptidase activity" RELATED []
synonym: "procollagen C-terminal proteinase activity" RELATED []
synonym: "procollagen carboxy-terminal proteinase activity" RELATED []
synonym: "procollagen carboxypeptidase activity" RELATED []
synonym: "procollagen peptidase activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0017027
name: obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "transmembrane receptor protein serine/threonine kinase receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0017028
name: obsolete protein stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jid]
comment: This term was made obsolete because it represents a biological process.
synonym: "protein stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050821

[Term]
id: GO:0017029
name: obsolete lysosomal protein stabilization
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "lysosomal protein stabilization" EXACT []
is_obsolete: true
consider: GO:0005764
consider: GO:0050821

[Term]
id: GO:0017030
name: obsolete beta-galactosidase stabilization activity
namespace: molecular_function
def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "beta-galactosidase stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050821

[Term]
id: GO:0017032
name: amino acid:potassium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai]
synonym: "potassium:amino acid symporter activity" EXACT []
is_a: GO:0005416 ! amino acid:monoatomic cation symporter activity
is_a: GO:0015079 ! potassium ion transmembrane transporter activity

[Term]
id: GO:0017038
name: protein import
namespace: biological_process
def: "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai]
synonym: "protein uptake" EXACT []
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0017039
name: obsolete dipeptidyl-peptidase III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "dipeptidyl aminopeptidase III activity" RELATED [EC:3.4.14.4]
synonym: "dipeptidyl arylamidase III activity" RELATED [EC:3.4.14.4]
synonym: "dipeptidyl-peptidase III activity" EXACT []
synonym: "DPP III activity" RELATED [EC:3.4.14.4]
synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4]
synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4]
is_obsolete: true
replaced_by: GO:0008239

[Term]
id: GO:0017040
name: N-acylsphingosine amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine." [RHEA:20856]
synonym: "acylsphingosine deacylase activity" RELATED [EC:3.5.1.23]
synonym: "ceramidase activity" NARROW []
synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23]
xref: EC:3.5.1.23
xref: MetaCyc:CERAMIDASE-RXN
xref: Reactome:R-HSA-1606583 "ASAH2 hydrolyzes ceramide (plasma membrane)"
xref: Reactome:R-HSA-1606602 "ASAH1 hydrolyzes ceramide"
xref: Reactome:R-HSA-428205 "ACER2 hydrolyzes ceramide (Golgi)"
xref: Reactome:R-HSA-428231 "ACER1 hydrolyzes ceramide (endoplasmic reticulum)"
xref: RHEA:20856
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017041
name: obsolete galactosylgalactosylglucosylceramidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47]
comment: This term was obsoleted because its corresponding EC has been remapped to 'alpha-galactosidase activity'; GO:0004557.
synonym: "ceramide trihexosidase activity" RELATED [EC:3.2.1.47]
synonym: "ceramidetrihexosidase activity" RELATED [EC:3.2.1.47]
synonym: "ceramidetrihexoside alpha-galactosidase activity" RELATED [EC:3.2.1.47]
synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" RELATED [EC:3.2.1.47]
synonym: "trihexosyl ceramide galactosidase activity" RELATED [EC:3.2.1.47]
synonym: "trihexosylceramide alpha-galactosidase activity" RELATED [EC:3.2.1.47]
is_obsolete: true
replaced_by: GO:0004557

[Term]
id: GO:0017042
name: glycosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62, PMID:10692580, PMID:9762914]
synonym: "cerebrosidase activity" RELATED [EC:3.2.1.62]
synonym: "glycosyl ceramide glycosylhydrolase activity" RELATED [EC:3.2.1.62]
synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" RELATED [EC:3.2.1.62]
xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0017043
name: obsolete adrenocorticotropin
namespace: molecular_function
def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "adrenocorticotropin" EXACT []
synonym: "corticotropin" BROAD []
is_obsolete: true
consider: GO:0005102
consider: GO:0046886
consider: GO:0046887

[Term]
id: GO:0017044
name: melanocyte-stimulating hormone activity
namespace: molecular_function
def: "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732]
synonym: "alpha-melanocyte stimulating hormone activity" NARROW [ISBN:0198506732]
synonym: "alpha-melanophore stimulating hormone activity" NARROW [ISBN:0198506732]
synonym: "melanocyte stimulating hormone activity" EXACT []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0017045
name: corticotropin-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary." [ISBN:0198506732]
synonym: "adrenocorticotropin-releasing hormone" EXACT []
xref: Wikipedia:Corticotropin-releasing_hormone
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0017046
name: peptide hormone binding
namespace: molecular_function
def: "Binding to a peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732]
synonym: "polypeptide hormone binding" EXACT []
is_a: GO:0033218 ! amide binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0017050
name: D-erythro-sphingosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [RHEA:35847]
synonym: "sphingosine kinase activity" BROAD []
xref: MetaCyc:RXN3DJ-11417
xref: Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate"
xref: Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation"
xref: RHEA:35847
is_a: GO:0008481 ! sphingosine kinase activity

[Term]
id: GO:0017051
name: retinol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081]
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0017052
name: obsolete insulin-like growth factor binding protein
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "insulin-like growth factor binding protein" EXACT []
is_obsolete: true
consider: GO:0016942

[Term]
id: GO:0017053
name: transcription repressor complex
namespace: cellular_component
alt_id: GO:0090568
alt_id: GO:0090569
def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]
subset: goslim_pir
synonym: "cytoplasmic transcriptional repressor complex" RELATED []
synonym: "nuclear transcriptional repressor complex" RELATED []
synonym: "transcription factor inhibitor complex" EXACT [GOC:bhm]
synonym: "transcriptional repressor complex" EXACT []
is_a: GO:0005667 ! transcription regulator complex

[Term]
id: GO:0017054
name: negative cofactor 2 complex
namespace: cellular_component
def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0017055
name: negative regulation of RNA polymerase II transcription preinitiation complex assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "down regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "downregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "inhibition of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0045898 ! regulation of RNA polymerase II transcription preinitiation complex assembly
is_a: GO:0060633 ! negative regulation of transcription initiation by RNA polymerase II
relationship: negatively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly

[Term]
id: GO:0017056
name: structural constituent of nuclear pore
namespace: molecular_function
alt_id: GO:0005487
def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]
comment: Note that this term is meant to be used for nuclear pore proteins. For importins and exportins, consider 'nuclear import signal receptor activity' or 'nuclear export signal receptor activity', respectively.
synonym: "nuclear pore activity" RELATED []
synonym: "nucleocytoplasmic transporter activity" EXACT []
xref: Reactome:R-HSA-1176059 "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus"
xref: Reactome:R-HSA-170796 "NPC transports GCK1:GKRP from cytosol to nucleoplasm"
xref: Reactome:R-HSA-192627 "Viral mRNA Export"
xref: Reactome:R-HSA-192925 "Export of Spliced Viral mRNA"
xref: Reactome:R-HSA-5252041 "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm"
xref: Reactome:R-HSA-5578744 "Importin-8 imports AGO2:miRNA into the nucleus"
xref: Reactome:R-HSA-5661474 "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm"
xref: Reactome:R-HSA-6783483 "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol"
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0017057
name: 6-phosphogluconolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+." [EC:3.1.1.31, RHEA:12556]
synonym: "6-PGL" RELATED [EC:3.1.1.31]
synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" RELATED [EC:3.1.1.31]
synonym: "phosphogluconolactonase activity" RELATED [EC:3.1.1.31]
xref: EC:3.1.1.31
xref: KEGG_REACTION:R02035
xref: MetaCyc:6PGLUCONOLACT-RXN
xref: Reactome:R-HSA-71296 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate"
xref: RHEA:12556
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0017058
name: FH1 domain binding
namespace: molecular_function
def: "Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0017059
name: serine palmitoyltransferase complex
namespace: cellular_component
def: "A protein complex that catalyses the condensation of L-serine with palmitoyl-CoA to form 3-ketosphinganine, the sphingoid base which is the starting point for all sphingolipids. In bacteria the enzyme is a cytoplasmic homodimer, whereas in eukaryotes the enzyme is a multiprotein complex localised to the endoplasmic reticulum. The eukaryotic complex consists of catalytic components (SPTLC1, SPTLC2 and SPTLC3 in humans; LCB1 and LCB2 in S. cerevisiae) and regulatory components, which include activators (SPTSSA/SPTSSB in humans, TSC3 in S. cerevisiae) and negative regulators (ORMDL1/ORMDL2/ORMDL3 in humans, ORM1/2 in S. cerevisiae )." [PMID:29863195, PMID:33558761]
synonym: "serine C-palmitoyltransferase complex" RELATED []
synonym: "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex" RELATED []
synonym: "SPOTS complex" RELATED []
synonym: "SPT" RELATED []
is_a: GO:0002178 ! palmitoyltransferase complex

[Term]
id: GO:0017060
name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]
synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65]
synonym: "alpha(1,4)-L-fucosyltransferase activity" BROAD []
synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" BROAD [EC:2.4.1.65]
synonym: "alpha-(1,4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "alpha-(1->4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "alpha-4-L-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "blood group Lewis alpha-4-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "blood-group substance Lea-dependent fucosyltransferase" BROAD [EC:2.4.1.65]
synonym: "fuca(1,3)-glycosidic linkage formation" RELATED []
synonym: "FucT-II activity" BROAD [EC:2.4.1.65]
synonym: "galactoside 3(4)-L-fucosyltransferase activity" BROAD []
synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65]
synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" RELATED [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65]
synonym: "Lewis alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis blood group alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis FT activity" BROAD [EC:2.4.1.65]
synonym: "Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity" BROAD []
synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65]
xref: EC:2.4.1.65
xref: MetaCyc:2.4.1.65-RXN
xref: Reactome:R-HSA-5693925 "FUT3 transfers L-fucose to Gal1,3GlcNAc"
xref: Reactome:R-HSA-9603986 "FUT3 transfers Fuc to Type 1 chains to form LeA"
xref: RHEA:23628
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0017061
name: S-methyl-5-thioadenosine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]
synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" RELATED [EC:2.4.2.28]
synonym: "5'-methylthioadenosine phosphorylase activity" EXACT []
synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" RELATED [EC:2.4.2.28]
synonym: "MeSAdo phosphorylase activity" RELATED [EC:2.4.2.28]
synonym: "MeSAdo/Ado phosphorylase activity" RELATED [EC:2.4.2.28]
synonym: "methylthioadenosine nucleoside phosphorylase activity" RELATED [EC:2.4.2.28]
synonym: "methylthioadenosine phosphorylase activity" RELATED [EC:2.4.2.28]
synonym: "MTA phosphorylase activity" RELATED [EC:2.4.2.28]
synonym: "MTAPase activity" RELATED [EC:2.4.2.28]
synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" RELATED [EC:2.4.2.28]
xref: EC:2.4.2.28
xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN
xref: Reactome:R-HSA-1237160 "MTA is cleaved and phosphorylated"
xref: RHEA:11852
is_a: GO:0004731 ! purine-nucleoside phosphorylase activity

[Term]
id: GO:0017062
name: respiratory chain complex III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, PMID:12833641, PMID:20116362]
synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT []
synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT []
synonym: "complex III assembly" EXACT []
synonym: "complex III biogenesis" EXACT []
synonym: "cytochrome bc(1) complex assembly" EXACT [GOC:mcc]
synonym: "cytochrome bc(1) complex biogenesis" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0017063
name: obsolete phosphatidylserine-specific phospholipase A1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [GOC:curators]
comment: This term was made obsolete because the definition does not match the term name.
synonym: "phosphatidylserine-specific phospholipase A1 activity" EXACT []
is_obsolete: true
consider: GO:0052739

[Term]
id: GO:0017064
name: fatty acid amide hydrolase activity
namespace: molecular_function
alt_id: GO:0017073
alt_id: GO:0102077
alt_id: GO:0103073
def: "Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893]
synonym: "anandamide amidohydrolase activity" NARROW []
synonym: "oleamide hydrolase activity" NARROW []
xref: EC:3.5.1.99
xref: Reactome:R-HSA-5693742 "FAAH hydrolyses AEA to AA and ETA"
xref: Reactome:R-HSA-5693751 "FAAH2 hydrolyses AEA to AA and ETA"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017065
name: single-strand selective uracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623]
synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT []
xref: Reactome:R-HSA-110221 "Cleavage of uracil by SMUG1 glycosylase"
is_a: GO:0004844 ! uracil DNA N-glycosylase activity

[Term]
id: GO:0017067
name: tyrosine-ester sulfotransferase activity
namespace: molecular_function
alt_id: GO:0008128
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H+." [EC:2.8.2.9, RHEA:19977]
synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" RELATED [EC:2.8.2.9]
synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9]
synonym: "L-tyrosine methyl ester sulfotransferase activity" RELATED [EC:2.8.2.9]
synonym: "tyrosine-ester sulphotransferase activity" EXACT []
xref: EC:2.8.2.9
xref: KEGG_REACTION:R04213
xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN
xref: RHEA:19977
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0017069
name: snRNA binding
namespace: molecular_function
alt_id: GO:0000945
def: "Binding to a small nuclear RNA (snRNA)." [GOC:mah]
synonym: "base pairing with snRNA" NARROW []
synonym: "small nuclear RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0017070
name: U6 snRNA binding
namespace: molecular_function
def: "Binding to a U6 small nuclear RNA (U6 snRNA)." [GOC:mah]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0017071
name: intracellular cyclic nucleotide activated cation channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0017072
name: obsolete tubulin-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "tubulin-specific chaperone activity" EXACT []
is_obsolete: true
consider: GO:0007021

[Term]
id: GO:0017074
name: obsolete procollagen N-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoprocollagen peptidase activity" RELATED []
synonym: "aminoterminal procollagen peptidase activity" RELATED []
synonym: "procollagen aminopeptidase activity" RELATED []
synonym: "procollagen aminoterminal protease activity" RELATED []
synonym: "procollagen N-endopeptidase activity" EXACT []
synonym: "procollagen N-proteinase activity" RELATED []
synonym: "procollagen N-terminal peptidase activity" RELATED []
synonym: "procollagen N-terminal proteinase activity" RELATED []
synonym: "type I/II procollagen N-proteinase activity" RELATED []
synonym: "type III procollagen" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0017075
name: syntaxin-1 binding
namespace: molecular_function
def: "Binding to a syntaxin-1 SNAP receptor." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0017076
name: purine nucleotide binding
namespace: molecular_function
def: "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0017077
name: oxidative phosphorylation uncoupler activity
namespace: molecular_function
alt_id: GO:0015302
def: "Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945]
synonym: "mitochondrial uncoupling protein activity" NARROW []
synonym: "uncoupling protein activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0017078
name: obsolete Hsc70 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'.
synonym: "Hsc70 interacting protein" BROAD []
synonym: "Hsc70 protein regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0031072
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0017080
name: sodium channel regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a sodium channel." [GOC:mah]
is_a: GO:0099106 ! ion channel regulator activity

[Term]
id: GO:0017081
name: chloride channel regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a chloride channel." [GOC:mah]
xref: Reactome:R-HSA-383190 "HCO3- transport through ion channel"
is_a: GO:0099106 ! ion channel regulator activity

[Term]
id: GO:0017082
name: obsolete mineralocorticoid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by binding to a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:20932876]
synonym: "aldosterone receptor" NARROW []
is_obsolete: true

[Term]
id: GO:0017083
name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152, RHEA:14257]
synonym: "galactoside 3-fucosyltransferase activity" RELATED [EC:2.4.1.152]
synonym: "galactoside 3-L-fucosyltransferase activity" EXACT []
synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.152]
synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" RELATED [EC:2.4.1.152]
synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" RELATED [EC:2.4.1.152]
synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" RELATED [EC:2.4.1.152]
synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" RELATED [EC:2.4.1.152]
synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152]
synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152]
xref: EC:2.4.1.152
xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN
xref: RHEA:14257
is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity

[Term]
id: GO:0017084
name: delta1-pyrroline-5-carboxylate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H+ + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP+ + phosphate." [RHEA:33207]
synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT []
xref: Reactome:R-HSA-508040 "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]"
xref: RHEA:33207
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0017085
name: response to insecticide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
synonym: "insecticide resistance" RELATED []
synonym: "insecticide susceptibility/resistance" RELATED []
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0017086
name: obsolete 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex
namespace: cellular_component
alt_id: GO:0031212
def: "OBSOLETE. A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [PMID:15612914]
comment: The reason for obsoletion is that this term is equivalent to GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex.
synonym: "BCADH" EXACT []
synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT []
is_obsolete: true
replaced_by: GO:0160157

[Term]
id: GO:0017087
name: mitochondrial processing peptidase complex
namespace: cellular_component
def: "A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [GOC:mah]
comment: Note that monomeric mitochondrial processing peptidases have been observed.
is_a: GO:0098798 ! mitochondrial protein-containing complex
is_a: GO:1905369 ! endopeptidase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017088
name: obsolete X-Pro dipeptidyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [GOC:curator]
comment: This term was made obsolete because it represents a gene product.
synonym: "X-Pro dipeptidyl-peptidase activity" EXACT []
synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008239

[Term]
id: GO:0017089
name: glycolipid transfer activity
namespace: molecular_function
def: "Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [PMID:30337668]
synonym: "glycolipid carrier activity" EXACT []
synonym: "glycolipid transporter activity" BROAD []
synonym: "intermembrane glycolipid transfer activity" NARROW []
synonym: "intermembrane glycolipid transporter activity" NARROW []
xref: Reactome:R-HSA-5340320 "GLTP transports GSL from plasma membrane to ER membrane"
xref: Reactome:R-HSA-9697077 "Rv1410c transports LprG:LM,LAM from cytosol to the cell wall"
xref: Reactome:R-HSA-9844955 "CLN3 transports GalCer to plasma membrane"
xref: Reactome:R-HSA-9845055 "PLEKHA8 catalyzes transport of GlcCer to plasma membrane"
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0017090
name: meprin A complex
namespace: cellular_component
def: "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [GOC:mah, MEROPS_fam:M12]
synonym: "PABA peptide hydrolase complex" EXACT []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0017092
name: obsolete sterol regulatory element-binding protein site 2 protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP site 2 protease activity" EXACT []
synonym: "sterol regulatory element-binding protein site 2 protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008237

[Term]
id: GO:0017093
name: obsolete sterol regulatory element-binding protein protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP protease activity" EXACT []
synonym: "sterol regulatory element-binding protein protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008233

[Term]
id: GO:0017094
name: obsolete sterol regulatory element-binding protein site 1 protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP site 1 protease activity" EXACT []
synonym: "sterol regulatory element-binding protein site 1 protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008236

[Term]
id: GO:0017095
name: heparan sulfate 6-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H+." [PMID:8631808, RHEA:56604]
synonym: "heparan sulfate 6-O-sulfotransferase activity" EXACT []
synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT []
synonym: "heparin 6-O-sulfotransferase activity" RELATED []
xref: Reactome:R-HSA-2076419 "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin"
xref: RHEA:56604
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0017096
name: acetylserotonin O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0017097
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine." [EC:2.1.1.4]
synonym: "acetylserotonin methyltransferase activity" RELATED [EC:2.1.1.4]
synonym: "hydroxyindole methyltransferase activity" RELATED [EC:2.1.1.4]
synonym: "hydroxyindole O-methyltransferase activity" RELATED [EC:2.1.1.4]
synonym: "N-acetylserotonin O-methyltransferase activity" RELATED [EC:2.1.1.4]
synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" RELATED [EC:2.1.1.4]
xref: EC:2.1.1.4
xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:15573
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0017098
name: sulfonylurea receptor binding
namespace: molecular_function
def: "Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023]
synonym: "sulfonylurea receptor ligand" NARROW []
synonym: "sulphonylurea receptor binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0017099
name: very-long-chain fatty acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [RHEA:19181]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very long-chain-acyl-CoA dehydrogenase activity" EXACT []
synonym: "very-long-chain acyl-CoA dehydrogenase activity" EXACT []
xref: EC:1.3.8.9
xref: MetaCyc:RXN-13451
xref: Reactome:R-HSA-548831 "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA"
xref: RHEA:19181
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0017101
name: aminoacyl-tRNA synthetase multienzyme complex
namespace: cellular_component
def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]
synonym: "aminoacyl-tRNA synthetase complex" EXACT []
synonym: "multisynthetase complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0017102
name: methionyl glutamyl tRNA synthetase complex
namespace: cellular_component
def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0017103
name: UTP:galactose-1-phosphate uridylyltransferase activity
namespace: molecular_function
alt_id: GO:0003982
def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose." [EC:2.7.7.10, RHEA:14209]
synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10]
synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10]
synonym: "galactose 1-phosphate uridyltransferase activity" RELATED [EC:2.7.7.10]
synonym: "galactose 1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10]
synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10]
synonym: "UDPgalactose pyrophosphorylase activity" RELATED [EC:2.7.7.10]
synonym: "uridine diphosphate galactose pyrophosphorylase activity" RELATED [EC:2.7.7.10]
synonym: "uridine diphosphogalactose pyrophosphorylase activity" RELATED [EC:2.7.7.10]
synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10]
synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10]
synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD []
xref: EC:2.7.7.10
xref: KEGG_REACTION:R00502
xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN
xref: RHEA:14209
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0017105
name: acyl-CoA delta11-(Z)-desaturase activity
namespace: molecular_function
alt_id: GO:0050601
def: "Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-delta-11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." [PMID:15063718, PMID:15544945, RHEA:25852]
synonym: "acyl-CoA D11-desaturase activity" EXACT []
synonym: "acyl-CoA delta(11)-desaturase activity" EXACT []
synonym: "acyl-CoA delta11-desaturase activity" BROAD []
synonym: "delta(11) desaturase" BROAD [EC:1.14.19.5]
synonym: "delta(11)-fatty-acid desaturase" BROAD [EC:1.14.19.5]
synonym: "delta(11)-palmitoyl-CoA desaturase" NARROW [EC:1.14.19.5]
synonym: "fatty acid delta(11)-desaturase" BROAD [EC:1.14.19.5]
synonym: "myristoyl-CoA 11-(Z) desaturase activity" NARROW []
synonym: "Z/E11-desaturase" BROAD [EC:1.14.19.5]
xref: EC:1.14.19.5
xref: MetaCyc:1.14.99.32-RXN
xref: RHEA:25852
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0017106
name: obsolete activin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it refers to an obsolete molecular function term, 'activin'.
synonym: "activin inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0098772

[Term]
id: GO:0017107
name: obsolete anion exchanger adaptor activity
namespace: molecular_function
def: "OBSOLETE. The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
comment: The term was made obsolete because it referred to an interaction of an anion transporter with the AP1 adaptor by which it is probably transported, see: PMID:22744004; PMID:20833140; ie the adaptor does not specifically target an anion adaptor.
is_obsolete: true

[Term]
id: GO:0017108
name: 5'-flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]
synonym: "5' flap endonuclease activity" EXACT []
xref: Reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA"
xref: Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"
xref: Reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand"
xref: Reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)"
xref: Reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ"
xref: Reactome:R-HSA-69152 "Removal of remaining Flap"
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters
is_a: GO:0048256 ! flap endonuclease activity

[Term]
id: GO:0017109
name: glutamate-cysteine ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [PMID:9675072]
synonym: "gamma-glutamylcysteine synthetase complex" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0017110
name: nucleoside diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate." [EC:3.6.1.6]
synonym: "apyrase activity" BROAD []
synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6]
synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6]
synonym: "NDPase activity" RELATED [EC:3.6.1.6]
synonym: "nucleoside 5'-diphosphatase activity" RELATED [EC:3.6.1.6]
synonym: "nucleoside diphosphatase activity" EXACT []
synonym: "nucleoside diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.6]
synonym: "nucleoside-diphosphatase activity" EXACT []
synonym: "nucleoside-diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.6]
synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6]
synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6]
xref: EC:3.6.1.6
xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN
xref: Reactome:R-HSA-8850854 "NTPDase1 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851129 "NTPDase3 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851225 "NTPDase4 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851356 "NTPDase5 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851396 "NTPDase6 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851550 "NTPDase8 hydrolyzes nucleoside diphosphates"
xref: RHEA:36799
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0017111
name: ribonucleoside triphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]
subset: goslim_chembl
subset: goslim_metagenomics
synonym: "apyrase activity" BROAD []
synonym: "NTPase activity" EXACT []
synonym: "nucleoside 5-triphosphatase activity" BROAD [EC:3.6.1.15]
synonym: "nucleoside triphosphatase activity" BROAD []
synonym: "nucleoside triphosphate hydrolase activity" BROAD []
synonym: "nucleoside triphosphate phosphatase activity" BROAD []
synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED []
synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED []
synonym: "nucleoside-triphosphatase activity" BROAD []
xref: EC:3.6.1.15
xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN
xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates"
xref: RHEA:23680
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0017113
name: dihydropyrimidine dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2]
synonym: "4,5-dihydrothymine: oxidoreductase activity" RELATED [EC:1.3.1.2]
synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" RELATED [EC:1.3.1.2]
synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.3.1.2]
synonym: "DHPDH" RELATED [EC:1.3.1.2]
synonym: "DHU dehydrogenase activity" RELATED [EC:1.3.1.2]
synonym: "dihydropyrimidine dehydrogenase activity" EXACT []
synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP)" RELATED [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP+) activity" RELATED [EC:1.3.1.2]
synonym: "DPD" RELATED [EC:1.3.1.2]
synonym: "hydropyrimidine dehydrogenase activity" RELATED [EC:1.3.1.2]
xref: EC:1.3.1.2
xref: MetaCyc:1.3.1.2-RXN
xref: Reactome:R-HSA-73585 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+"
xref: Reactome:R-HSA-73616 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+"
xref: RHEA:18093
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0017114
name: obsolete wide-spectrum protease inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it represents a regulator of non-existent molecular function.
synonym: "wide-spectrum protease inhibitor activity" EXACT []
synonym: "wide-spectrum proteinase inhibitor" EXACT []
is_obsolete: true
replaced_by: GO:0030414

[Term]
id: GO:0017116
name: single-stranded DNA helicase activity
namespace: molecular_function
alt_id: GO:0043142
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]
synonym: "single-stranded DNA-dependent ATP-dependent DNA helicase activity" EXACT []
synonym: "single-stranded DNA-dependent ATPase activity" EXACT []
synonym: "ssDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:mah]
synonym: "ssDNA-dependent ATPase activity" EXACT []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0017117
name: single-stranded DNA-dependent ATP-dependent DNA helicase complex
namespace: cellular_component
def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah]
synonym: "ssDNA-dependent ATP-dependent DNA helicase complex" EXACT [GOC:mah]
is_a: GO:0033202 ! DNA helicase complex

[Term]
id: GO:0017118
name: lipoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+." [PMID:10103005, RHEA:20473]
xref: RHEA:20473
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0017119
name: Golgi transport complex
namespace: cellular_component
def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]
synonym: "COG complex" EXACT []
synonym: "conserved oligomeric Golgi complex" EXACT []
synonym: "Sec34/35 complex" NARROW []
is_a: GO:0099023 ! vesicle tethering complex
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0017120
name: obsolete polyphosphatidylinositol phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048]
comment: This term was made obsolete because it represents a gene product.
synonym: "polyphosphatidylinositol phosphatase activity" EXACT []
synonym: "polyphosphoinositide phosphatase activity" EXACT []
is_obsolete: true
consider: GO:0004438
consider: GO:0034593
consider: GO:0043812

[Term]
id: GO:0017121
name: plasma membrane phospholipid scrambling
namespace: biological_process
def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864]
comment: Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
synonym: "phospholipid scrambling" RELATED []
synonym: "PL scrambling" EXACT []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0045332 ! phospholipid translocation

[Term]
id: GO:0017122
name: protein N-acetylglucosaminyltransferase complex
namespace: cellular_component
def: "A protein complex capable of protein N-acetylglucosaminyltransferase activity, the addition of nucleotide-activated sugars onto the polypeptide according to reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. The complex has different compositions in different species: In mammals it is often a homotrimer, in bacteria a heterotetramer of 2 different subunits." [PMID:15247246]
synonym: "O-GlcNAc transferase complex" EXACT [GOC:mah]
synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase" EXACT [GOC:mah]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0017124
name: SH3 domain binding
namespace: molecular_function
def: "Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0017125
name: deoxycytidyl transferase activity
namespace: molecular_function
alt_id: GO:0019986
def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901]
synonym: "deoxycytidyl transferase activity, template-dependent" NARROW []
xref: Reactome:R-HSA-110308 "REV1 inserts dCMP opposite to AP sites in DNA"
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0017126
name: nucleologenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732]
synonym: "nucleolus assembly" NARROW [GOC:mah]
synonym: "nucleolus biogenesis" EXACT []
is_a: GO:0007000 ! nucleolus organization
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0017128
name: phospholipid scramblase activity
namespace: molecular_function
def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]
comment: Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases).
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0140303 ! intramembrane lipid transporter activity

[Term]
id: GO:0017129
name: triglyceride binding
namespace: molecular_function
def: "Binding to a triester of glycerol." [GOC:jl, ISBN:0198506732]
synonym: "triacylglycerol binding" EXACT [GOC:mah]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0017130
name: poly(C) RNA binding
namespace: molecular_function
def: "Binding to a sequence of cytosine residues in an RNA molecule." [GOC:mah]
synonym: "poly(C) binding" BROAD [GOC:mah]
synonym: "poly(rC) binding" EXACT [GOC:mah]
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0017131
name: uridine-rich cytoplasmic polyadenylylation element binding
namespace: molecular_function
def: "Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828]
synonym: "U-rich CPE binding" EXACT [PMID:7954828]
synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT []
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0017133
name: mitochondrial electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732]
is_a: GO:0045251 ! electron transfer flavoprotein complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017134
name: fibroblast growth factor binding
namespace: molecular_function
alt_id: GO:0048602
alt_id: GO:0048603
alt_id: GO:0048604
alt_id: GO:0048605
alt_id: GO:0048606
alt_id: GO:0048607
def: "Binding to a fibroblast growth factor." [PMID:9806903]
synonym: "FGF 1 binding" NARROW []
synonym: "FGF 2 binding" NARROW []
synonym: "FGF 3 binding" NARROW []
synonym: "FGF 4 binding" NARROW []
synonym: "FGF 5 binding" NARROW []
synonym: "FGF 6 binding" NARROW []
synonym: "FGF binding" EXACT []
synonym: "fibroblast growth factor 1 binding" NARROW []
synonym: "fibroblast growth factor 2 binding" NARROW []
synonym: "fibroblast growth factor 3 binding" NARROW []
synonym: "fibroblast growth factor 4 binding" NARROW []
synonym: "fibroblast growth factor 5 binding" NARROW []
synonym: "fibroblast growth factor 6 binding" NARROW []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0017135
name: obsolete membrane-associated protein with guanylate kinase activity interacting
namespace: molecular_function
def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005]
comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense.
synonym: "membrane-associated protein with guanylate kinase activity interacting" EXACT []
is_obsolete: true
consider: GO:0019899

[Term]
id: GO:0017136
name: histone deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide." [PMID:24691964, PMID:28450737]
comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
synonym: "histone deacetylase activity" BROAD []
synonym: "NAD-dependent histone deacetylase activity" EXACT []
synonym: "NAD-dependent histone lysine deacetylase activity" EXACT []
synonym: "SIR2" RELATED []
synonym: "sirtuin" NARROW []
is_a: GO:0004407 ! histone deacetylase activity
is_a: GO:0034979 ! NAD-dependent protein lysine deacetylase activity

[Term]
id: GO:0017139
name: obsolete arsenate sensitivity/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "arsenate sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046685

[Term]
id: GO:0017141
name: obsolete antibiotic susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "antibiotic susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046677

[Term]
id: GO:0017142
name: obsolete toxin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "toxin susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009636

[Term]
id: GO:0017143
name: insecticide metabolic process
namespace: biological_process
alt_id: GO:0017138
def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]
synonym: "insecticide metabolism" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0009404 ! toxin metabolic process
relationship: part_of GO:0017085 ! response to insecticide

[Term]
id: GO:0017145
name: stem cell division
namespace: biological_process
def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089]
synonym: "stem cell renewal" EXACT []
is_a: GO:0051301 ! cell division

[Term]
id: GO:0017146
name: NMDA selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [PMID:8294079]
synonym: "N-methyl-D-aspartate selective glutamate receptor complex" EXACT []
synonym: "NMDA-selective glutamate receptor" EXACT []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0017147
name: Wnt-protein binding
namespace: molecular_function
def: "Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0017148
name: negative regulation of translation
namespace: biological_process
alt_id: GO:0016478
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]
synonym: "down regulation of protein biosynthetic process" EXACT []
synonym: "down-regulation of protein biosynthetic process" EXACT []
synonym: "downregulation of protein biosynthetic process" EXACT []
synonym: "inhibition of protein biosynthetic process" NARROW []
synonym: "negative regulation of protein anabolism" EXACT []
synonym: "negative regulation of protein biosynthesis" EXACT []
synonym: "negative regulation of protein biosynthetic process" EXACT []
synonym: "negative regulation of protein formation" EXACT []
synonym: "negative regulation of protein synthesis" EXACT []
synonym: "protein biosynthesis inhibitor activity" RELATED []
synonym: "protein biosynthetic process inhibitor activity" RELATED []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0006412 ! translation

[Term]
id: GO:0017149
name: obsolete protein biosynthetic process inhibitor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "protein anabolism inhibitor activity" EXACT []
synonym: "protein biosynthetic process inhibitor activity" EXACT []
synonym: "protein formation inhibitor activity" EXACT []
synonym: "protein synthesis inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0017148

[Term]
id: GO:0017150
name: tRNA dihydrouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]
xref: Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs"
is_a: GO:0106413 ! RNA dihydrouridine synthase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0017151
name: DEAD/H-box RNA helicase binding
namespace: molecular_function
def: "Binding to a DEAD/H-box RNA helicase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0017153
name: sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
synonym: "sodium:dicarboxylate cotransporter activity" BROAD []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity

[Term]
id: GO:0017154
name: semaphorin receptor activity
namespace: molecular_function
def: "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0017155
name: obsolete sodium:hydrogen antiporter regulator activity
namespace: molecular_function
alt_id: GO:0030040
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it represents a biological process.
synonym: "sodium:hydrogen antiporter regulator activity" EXACT []
synonym: "sodium:proton antiporter regulator" EXACT []
is_obsolete: true

[Term]
id: GO:0017156
name: calcium-ion regulated exocytosis
namespace: biological_process
def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]
comment: Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway.
synonym: "calcium ion-dependent exocytosis" EXACT []
is_a: GO:0045055 ! regulated exocytosis

[Term]
id: GO:0017157
name: regulation of exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0006887 ! exocytosis

[Term]
id: GO:0017158
name: regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
is_a: GO:1903305 ! regulation of regulated secretory pathway
relationship: regulates GO:0017156 ! calcium-ion regulated exocytosis

[Term]
id: GO:0017159
name: pantetheine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13445]
synonym: "(R)-pantetheine amidohydrolase activity" RELATED [EC:3.5.1.92]
synonym: "pantetheinase activity" RELATED [EC:3.5.1.92]
synonym: "vanin" RELATED [EC:3.5.1.92]
synonym: "vanin-1" RELATED [EC:3.5.1.92]
xref: EC:3.5.1.92
xref: KEGG_REACTION:R02973
xref: MetaCyc:3.5.1.92-RXN
xref: Reactome:R-HSA-8938300 "Vanin hydrolyses pantetheine to PanK, 2AET"
xref: RHEA:13445
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017161
name: inositol-1,3,4-trisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai]
xref: Reactome:R-HSA-1855180 "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol"
xref: RHEA:43392
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0017162
name: aryl hydrocarbon receptor binding
namespace: molecular_function
def: "Binding to an aryl hydrocarbon receptor." [GOC:ai]
is_a: GO:0005102 ! signaling receptor binding
is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding

[Term]
id: GO:0017163
name: obsolete basal transcription repressor activity
namespace: molecular_function
def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "basal transcription repressor activity" EXACT []
is_obsolete: true
consider: GO:0001217
consider: GO:0001227
consider: GO:0045892

[Term]
id: GO:0017164
name: obsolete nicotinic acetylcholine receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "nicotinic acetylcholine receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0017165
name: obsolete dipeptidase E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-aspartyl dipeptidase activity" EXACT []
synonym: "aspartyl dipeptidase activity" RELATED [EC:3.4.13.21]
synonym: "dipeptidase E activity" EXACT []
synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21]
synonym: "peptidase E activity" BROAD [EC:3.4.13.21]
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0017166
name: vinculin binding
namespace: molecular_function
def: "Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0017168
name: 5-oxoprolinase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate." [EC:3.5.2.9, RHEA:10348]
synonym: "5-OPase activity" RELATED [EC:3.5.2.9]
synonym: "5-oxo-L-prolinase activity" RELATED [EC:3.5.2.9]
synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" RELATED [EC:3.5.2.9]
synonym: "5-oxoprolinase (ATP-hydrolysing)" RELATED [EC:3.5.2.9]
synonym: "5-oxoprolinase activity" RELATED [EC:3.5.2.9]
synonym: "L-pyroglutamate hydrolase activity" RELATED [EC:3.5.2.9]
synonym: "oxoprolinase activity" RELATED [EC:3.5.2.9]
synonym: "pyroglutamase (ATP-hydrolysing)" RELATED [EC:3.5.2.9]
synonym: "pyroglutamase (ATP-hydrolyzing) activity" RELATED [EC:3.5.2.9]
synonym: "pyroglutamase activity" RELATED [EC:3.5.2.9]
synonym: "pyroglutamate hydrolase activity" RELATED [EC:3.5.2.9]
synonym: "pyroglutamic hydrolase activity" RELATED [EC:3.5.2.9]
xref: EC:3.5.2.9
xref: KEGG_REACTION:R00251
xref: MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN
xref: Reactome:R-HSA-1247935 "OPLAH hydrolyses OPRO to L-Glu"
xref: Reactome:R-HSA-5603208 "Defective OPLAH does not hydrolyse OPRO"
xref: RHEA:10348
xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing)
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0017169
name: CDP-alcohol phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai]
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0017170
name: obsolete KU70 binding
namespace: molecular_function
def: "OBSOLETE. Binding to Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "KU70 binding" EXACT []
is_obsolete: true

[Term]
id: GO:0017171
name: serine hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0017172
name: cysteine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H+." [EC:1.13.11.20, RHEA:20441]
xref: EC:1.13.11.20
xref: KEGG_REACTION:R00893
xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN
xref: Reactome:R-HSA-1614645 "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine"
xref: RHEA:20441
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0017174
name: glycine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]
synonym: "glycine methyltransferase activity" RELATED [EC:2.1.1.20]
synonym: "GNMT" RELATED [EC:2.1.1.20]
synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" RELATED [EC:2.1.1.20]
synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" RELATED [EC:2.1.1.20]
xref: EC:2.1.1.20
xref: KEGG_REACTION:R00367
xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-6798317 "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC"
xref: RHEA:19937
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0017175
name: obsolete IMP-GMP specific 5'-nucleotidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc]
comment: This term was made obsolete because it represents a gene product with two different activities.
synonym: "IMP-GMP specific 5'-nucleotidase activity" EXACT []
is_obsolete: true
consider: GO:0050484

[Term]
id: GO:0017176
name: phosphatidylinositol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]
synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" RELATED [EC:2.4.1.198]
synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.198]
synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.198]
synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.198]
xref: EC:2.4.1.198
xref: MetaCyc:2.4.1.198-RXN
xref: RHEA:14789
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0017177
name: glucosidase II complex
namespace: cellular_component
def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]
comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term.
synonym: "alpha-glucosidase II complex" RELATED [GOC:19605557, GOC:vw]
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1902687 ! glucosidase complex

[Term]
id: GO:0017178
name: diphthine-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate." [EC:6.3.1.14, RHEA:19753]
synonym: "diphthamide synthase activity" RELATED [EC:6.3.1.14]
synonym: "diphthamide synthetase activity" RELATED [EC:6.3.1.14]
synonym: "diphthine:ammonia ligase (ADP-forming)" RELATED [EC:6.3.1.14]
xref: EC:6.3.1.14
xref: KEGG_REACTION:R03613
xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN
xref: Reactome:R-HSA-5358475 "DPH6 ligates ammonium to diphthine-EEF2"
xref: RHEA:19753
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0017179
name: obsolete peptidyl-diphthine metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "peptidyl-diphthine metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0017180
name: obsolete protein histidyl modification to diphthine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthine biosynthetic process from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT []
is_obsolete: true

[Term]
id: GO:0017181
name: obsolete peptidyl-diphthine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "peptidyl-diphthine breakdown" EXACT []
synonym: "peptidyl-diphthine catabolism" EXACT []
synonym: "peptidyl-diphthine degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0017182
name: obsolete peptidyl-diphthamide metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "peptidyl-diphthamide metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0017183
name: protein histidyl modification to diphthamide
namespace: biological_process
def: "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380]
synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthamide biosynthetic process from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT []
xref: RESID:AA0040
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0017184
name: obsolete peptidyl-diphthamide catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "peptidyl-diphthamide breakdown" EXACT []
synonym: "peptidyl-diphthamide catabolism" EXACT []
synonym: "peptidyl-diphthamide degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0017185
name: peptidyl-lysine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0017186
name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031]
comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'.
subset: gocheck_do_not_annotate
synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT []
synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT []
synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT []
xref: RESID:AA0031
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0017187
name: peptidyl-glutamic acid carboxylation
namespace: biological_process
def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]
comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'.
subset: gocheck_obsoletion_candidate
xref: RESID:AA0032
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018214 ! protein carboxylation

[Term]
id: GO:0017188
name: aspartate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H+." [RHEA:14165]
synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" RELATED [EC:2.3.1.17]
synonym: "aspartate acetyltransferase activity" RELATED [EC:2.3.1.17]
synonym: "L-aspartate N-acetyltransferase activity" RELATED [EC:2.3.1.17]
xref: EC:2.3.1.17
xref: KEGG_REACTION:R00487
xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-8954468 "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA"
xref: RHEA:14165
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0017189
name: obsolete N-terminal peptidyl-alanine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0017190
name: N-terminal peptidyl-aspartic acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042]
comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'.
subset: gocheck_obsoletion_candidate
xref: RESID:AA0042
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0017192
name: N-terminal peptidyl-glutamine acetylation
namespace: biological_process
def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0045
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0017193
name: obsolete N-terminal peptidyl-glycine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0017194
name: obsolete N-terminal peptidyl-isoleucine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0017195
name: obsolete N-terminal peptidyl-lysine N2-acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed." [RESID:AA0048]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0017196
name: N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0049
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0017197
name: obsolete N-terminal peptidyl-proline acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0017198
name: obsolete N-terminal peptidyl-serine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0017199
name: obsolete N-terminal peptidyl-threonine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018000
name: obsolete N-terminal peptidyl-tyrosine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018001
name: obsolete N-terminal peptidyl-valine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018002
name: N-terminal peptidyl-glutamic acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid." [RESID:AA0044]
comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'.
subset: gocheck_obsoletion_candidate
xref: RESID:AA0044
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018003
name: peptidyl-lysine N6-acetylation
namespace: biological_process
def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine." [RESID:AA0055]
comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'.
subset: gocheck_obsoletion_candidate
xref: RESID:AA0055
is_a: GO:0018393 ! internal peptidyl-lysine acetylation

[Term]
id: GO:0018004
name: N-terminal protein formylation
namespace: biological_process
def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0018256 ! protein formylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018005
name: obsolete N-terminal peptidyl-glycine N-formylation
namespace: biological_process
def: "OBSOLETE. The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018006
name: N-terminal protein amino acid glucuronylation
namespace: biological_process
def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai]
is_a: GO:0018321 ! protein glucuronylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018007
name: N-terminal peptidyl-glycine N-glucuronylation
namespace: biological_process
def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058]
xref: RESID:AA0058
is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018008
name: N-terminal peptidyl-glycine N-myristoylation
namespace: biological_process
def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059]
subset: gocheck_obsoletion_candidate
synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT []
xref: RESID:AA0059
is_a: GO:0006499 ! N-terminal protein myristoylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018009
name: N-terminal peptidyl-L-cysteine N-palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0060
is_a: GO:0006500 ! N-terminal protein palmitoylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018010
name: obsolete glycoprotein N-palmitoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96]
comment: This term was obsoleted because it has been deleted from EC. The glycoprotein is the product of the reaction.
synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96]
synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" RELATED [EC:2.3.1.96]
is_obsolete: true

[Term]
id: GO:0018011
name: N-terminal peptidyl-alanine methylation
namespace: biological_process
def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0061
xref: RESID:AA0062
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0018012
name: N-terminal peptidyl-alanine trimethylation
namespace: biological_process
def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0062
is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation

[Term]
id: GO:0018013
name: N-terminal peptidyl-glycine methylation
namespace: biological_process
def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0063
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018014
name: obsolete N-terminal peptidyl-methionine methylation
namespace: biological_process
def: "OBSOLETE. The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018015
name: obsolete N-terminal peptidyl-phenylalanine methylation
namespace: biological_process
def: "OBSOLETE. The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018016
name: N-terminal peptidyl-proline dimethylation
namespace: biological_process
def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0066
is_a: GO:0035568 ! N-terminal peptidyl-proline methylation

[Term]
id: GO:0018019
name: obsolete N-terminal peptidyl-glutamine methylation
namespace: biological_process
def: "OBSOLETE. The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018020
name: obsolete peptidyl-glutamic acid methylation
namespace: biological_process
def: "OBSOLETE. The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018021
name: peptidyl-histidine methylation
namespace: biological_process
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0073
xref: RESID:AA0317
is_a: GO:0006479 ! protein methylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018022
name: peptidyl-lysine methylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0006479 ! protein methylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018023
name: peptidyl-lysine trimethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0074
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018024
name: obsolete histone lysine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [RHEA:10024]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" NARROW []
synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah]
synonym: "histone-lysine N-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" RELATED []
is_obsolete: true
consider: GO:0140938
consider: GO:0140939
consider: GO:0140940

[Term]
id: GO:0018025
name: calmodulin-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60]
synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" RELATED [EC:2.1.1.60]
synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" RELATED [EC:2.1.1.60]
synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" RELATED [EC:2.1.1.60]
xref: EC:2.1.1.60
xref: MetaCyc:2.1.1.60-RXN
xref: Reactome:R-HSA-6786205 "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1"
xref: RHEA:21556
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity

[Term]
id: GO:0018026
name: peptidyl-lysine monomethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0076
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018027
name: peptidyl-lysine dimethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0075
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018028
name: obsolete peptidyl-lysine myristoylation
namespace: biological_process
def: "OBSOLETE. The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-lysine myristylation" EXACT []
is_obsolete: true

[Term]
id: GO:0018029
name: obsolete peptidyl-lysine palmitoylation
namespace: biological_process
def: "OBSOLETE. The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018030
name: peptidyl-lysine N6-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah, PMID:1402651]
is_a: GO:0019107 ! myristoyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0018031
name: peptidyl-lysine N6-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah, PMID:29074776]
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0018032
name: obsolete protein amidation
namespace: biological_process
def: "OBSOLETE. Addition of an amide group from a glycine to a protein amino acid." [UniProtKB-KW:KW-0027]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid amidation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0018033
name: obsolete protein C-terminal amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018034
name: obsolete C-terminal peptidyl-alanine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0081
is_obsolete: true

[Term]
id: GO:0018035
name: obsolete C-terminal peptidyl-arginine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0082
is_obsolete: true

[Term]
id: GO:0018036
name: obsolete C-terminal peptidyl-asparagine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0083
is_obsolete: true

[Term]
id: GO:0018037
name: obsolete C-terminal peptidyl-aspartic acid amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0084
is_obsolete: true

[Term]
id: GO:0018038
name: obsolete C-terminal peptidyl-cysteine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0085
is_obsolete: true

[Term]
id: GO:0018039
name: obsolete C-terminal peptidyl-glutamine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0086
is_obsolete: true

[Term]
id: GO:0018040
name: obsolete C-terminal peptidyl-glutamic acid amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0087
is_obsolete: true

[Term]
id: GO:0018041
name: obsolete C-terminal peptidyl-glycine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088]
comment: This term was obsoleted because it represents a molecular function.
xref: RESID:AA0088
is_obsolete: true
consider: GO:0004504
consider: GO:0004598

[Term]
id: GO:0018042
name: obsolete C-terminal peptidyl-histidine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0089
is_obsolete: true

[Term]
id: GO:0018043
name: obsolete C-terminal peptidyl-isoleucine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0090
is_obsolete: true

[Term]
id: GO:0018044
name: obsolete C-terminal peptidyl-leucine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0091
is_obsolete: true

[Term]
id: GO:0018045
name: obsolete C-terminal peptidyl-lysine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0092
is_obsolete: true

[Term]
id: GO:0018046
name: obsolete C-terminal peptidyl-methionine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0093
is_obsolete: true

[Term]
id: GO:0018047
name: obsolete C-terminal peptidyl-phenylalanine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0094
is_obsolete: true

[Term]
id: GO:0018048
name: obsolete C-terminal peptidyl-proline amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0095
is_obsolete: true

[Term]
id: GO:0018049
name: obsolete C-terminal peptidyl-serine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0096
is_obsolete: true

[Term]
id: GO:0018050
name: obsolete C-terminal peptidyl-threonine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0097
is_obsolete: true

[Term]
id: GO:0018051
name: obsolete C-terminal peptidyl-tryptophan amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0098
is_obsolete: true

[Term]
id: GO:0018052
name: obsolete C-terminal peptidyl-tyrosine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0099
is_obsolete: true

[Term]
id: GO:0018053
name: obsolete C-terminal peptidyl-valine amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100]
comment: This term was obsoleted because it represents a molecular function, and this modification is not known to exist; only c-terminal peptidylglycine has been identified, see PMID:35124797.
xref: RESID:AA0100
is_obsolete: true

[Term]
id: GO:0018054
name: obsolete peptidyl-lysine biotinylation
namespace: biological_process
def: "OBSOLETE. The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
comment: This terms was obsoleted because it represents a molecular function as a biological process.
xref: RESID:AA0117
is_obsolete: true

[Term]
id: GO:0018057
name: peptidyl-lysine oxidation
namespace: biological_process
def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0121
is_a: GO:0018158 ! protein oxidation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018058
name: N-terminal protein amino acid deamination, from amino carbon
namespace: biological_process
def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0127
xref: RESID:AA0128
xref: RESID:AA0129
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018277 ! protein deamination
is_a: GO:0031363 ! N-terminal protein amino acid deamination

[Term]
id: GO:0018059
name: obsolete N-terminal peptidyl-serine deamination
namespace: biological_process
def: "OBSOLETE. The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018060
name: obsolete N-terminal peptidyl-cysteine deamination
namespace: biological_process
def: "OBSOLETE. The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018061
name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine
namespace: biological_process
def: "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128]
subset: gocheck_do_not_annotate
synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT []
xref: RESID:AA0128
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018062
name: obsolete peptidyl-tryptophan succinylation
namespace: biological_process
def: "OBSOLETE. The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018063
name: cytochrome c-heme linkage
namespace: biological_process
def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135]
subset: gocheck_obsoletion_candidate
synonym: "cytochrome c-haem linkage" EXACT []
xref: RESID:AA0134
xref: RESID:AA0135
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018064
name: protein-L-histidine N-tele-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine." [RHEA:19369]
synonym: "actin-specific histidine methyltransferase activity" RELATED [EC:2.1.1.85]
synonym: "peptidyl-histidine N-methyltransferase activity" EXACT []
synonym: "protein (histidine) methyltransferase activity" RELATED [EC:2.1.1.85]
synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85]
synonym: "protein-histidine N-methyltransferase activity" BROAD []
synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" RELATED [EC:2.1.1.85]
synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" RELATED [EC:2.1.1.85]
xref: EC:2.1.1.85
xref: MetaCyc:2.1.1.85-RXN
xref: RHEA:19369
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018065
name: obsolete protein-cofactor linkage
namespace: biological_process
def: "OBSOLETE. The covalent attachment of a cofactor to a protein." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group protein modification processes that are not all chemically related by the fact that they may be used as a cofactor.
is_obsolete: true

[Term]
id: GO:0018067
name: obsolete peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT []
is_obsolete: true

[Term]
id: GO:0018068
name: obsolete peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT []
is_obsolete: true

[Term]
id: GO:0018069
name: obsolete peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone
namespace: biological_process
def: "OBSOLETE. The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149]
comment: This term was obsoleted because it represents a cofactor, see PMID:2028257.
xref: RESID:AA0149
is_obsolete: true

[Term]
id: GO:0018070
name: peptidyl-serine phosphopantetheinylation
namespace: biological_process
def: "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0150
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018215 ! protein phosphopantetheinylation

[Term]
id: GO:0018071
name: obsolete NAD(P)-cysteine ADP-ribosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [GOC:curators]
comment: This term was obsoleted because it corresponds to the same reaction as NAD+- protein-cysteine ADP-ribosyltransferase activity ; GO:0140803.
is_obsolete: true
replaced_by: GO:0140803

[Term]
id: GO:0018072
name: obsolete peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT []
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT []
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT []
is_obsolete: true

[Term]
id: GO:0018073
name: obsolete protein bromination
namespace: biological_process
def: "OBSOLETE. The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah]
synonym: "protein amino acid bromination" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0018074
name: obsolete peptidyl-histidine bromination
namespace: biological_process
def: "OBSOLETE. The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173]
xref: RESID:AA0173
is_obsolete: true

[Term]
id: GO:0018075
name: obsolete peptidyl-phenylalanine bromination
namespace: biological_process
def: "OBSOLETE. The bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176]
xref: RESID:AA0174
xref: RESID:AA0175
xref: RESID:AA0176
is_obsolete: true

[Term]
id: GO:0018076
name: N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:0018077
name: obsolete protein iodination
namespace: biological_process
def: "OBSOLETE. The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah]
synonym: "protein amino acid iodination" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0018078
name: obsolete peptidyl-thyronine iodination
namespace: biological_process
def: "OBSOLETE. The iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178]
xref: RESID:AA0177
xref: RESID:AA0178
is_obsolete: true

[Term]
id: GO:0018079
name: obsolete protein halogenation
namespace: biological_process
def: "OBSOLETE. The addition of a halogen to a protein amino acid." [GOC:ai]
synonym: "protein amino acid halogenation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0018080
name: obsolete peptidyl-tryptophan bromination
namespace: biological_process
def: "OBSOLETE. The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179]
xref: RESID:AA0179
is_obsolete: true

[Term]
id: GO:0018081
name: obsolete peptide cross-linking via lanthionine or 3-methyl-lanthionine
namespace: biological_process
def: "OBSOLETE. The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT []
synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT []
xref: RESID:AA0110
xref: RESID:AA0111
xref: RESID:AA0112
is_obsolete: true

[Term]
id: GO:0018082
name: obsolete peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine
namespace: biological_process
def: "OBSOLETE. The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine." [RESID:AA0182]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT []
synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT []
synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT []
is_obsolete: true

[Term]
id: GO:0018083
name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine
namespace: biological_process
def: "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185]
subset: gocheck_do_not_annotate
synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT []
xref: RESID:AA0185
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018084
name: obsolete peptidyl-lactic acid biosynthetic process from peptidyl-serine
namespace: biological_process
def: "OBSOLETE. The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT []
synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT []
synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT []
is_obsolete: true

[Term]
id: GO:0018085
name: peptidyl-L-amino acid racemization
namespace: biological_process
def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma]
subset: gocheck_do_not_annotate
is_a: GO:0018193 ! peptidyl-amino acid modification
is_a: GO:0018366 ! chiral amino acid racemization

[Term]
id: GO:0018086
name: obsolete alanine racemization
namespace: biological_process
alt_id: GO:0018368
def: "OBSOLETE. (Was not defined before being made obsolete)." [RESID:AA0191]
comment: This term was made obsolete because it was replaced with more appropriate terms.
synonym: "alanine racemization" EXACT []
is_obsolete: true
consider: GO:0019122

[Term]
id: GO:0018091
name: obsolete peptidyl-asparagine racemization
namespace: biological_process
alt_id: GO:0018373
alt_id: GO:0019127
def: "OBSOLETE. The racemization of peptidyl-asparagine." [RESID:AA0196]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018094
name: protein polyglycylation
namespace: biological_process
def: "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0201
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018095
name: protein polyglutamylation
namespace: biological_process
def: "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0202
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018096
name: obsolete peptide cross-linking via S-(2-aminovinyl)-D-cysteine
namespace: biological_process
def: "OBSOLETE. The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0204
is_obsolete: true

[Term]
id: GO:0018097
name: obsolete protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207]
comment: Term describes modified products or self-catalyzed processes.
synonym: "protein amino acid cinnamylation" BROAD []
xref: RESID:AA0207
is_obsolete: true

[Term]
id: GO:0018101
name: obsolete protein citrullination
namespace: biological_process
def: "OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [PMID:23175390, RESID:AA0214]
comment: This term was obsoleted because it represents a molecular function.
synonym: "deimination" EXACT [Wikipedia:Citrullination]
synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT []
synonym: "peptidyl-citrulline biosynthetic process from peptidyl-arginine" EXACT [RESID:AA0214]
synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT []
synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT []
xref: RESID:AA0214
is_obsolete: true
consider: GO:0004668

[Term]
id: GO:0018102
name: obsolete peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018103
name: protein C-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom." [GOC:pr, PMID:7947762, RESID:AA0217]
synonym: "protein amino acid C-linked glycosylation" EXACT [GOC:bf]
xref: RESID:AA0217
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0018104
name: peptidoglycan-protein cross-linking
namespace: biological_process
def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg]
is_a: GO:0009252 ! peptidoglycan biosynthetic process

[Term]
id: GO:0018105
name: peptidyl-serine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0037
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018106
name: peptidyl-histidine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0035
xref: RESID:AA0036
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018107
name: peptidyl-threonine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0038
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018108
name: peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0039
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018109
name: peptidyl-arginine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0222
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018110
name: obsolete histone arginine kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H+." [GOC:mah]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "histone-arginine kinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018111
name: methionine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2, RHEA:12492]
xref: EC:5.1.1.2
xref: KEGG_REACTION:R00655
xref: MetaCyc:METHIONINE-RACEMASE-RXN
xref: RHEA:12492
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018112
name: proline racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4, RHEA:10680]
xref: EC:5.1.1.4
xref: KEGG_REACTION:R01255
xref: MetaCyc:PROLINE-RACEMASE-RXN
xref: RHEA:10680
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018113
name: lysine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5]
xref: EC:5.1.1.5
xref: MetaCyc:LYSINE-RACEMASE-RXN
xref: RHEA:22864
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018114
name: threonine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6, RHEA:13913]
xref: EC:5.1.1.6
xref: KEGG_REACTION:R01467
xref: MetaCyc:THREONINE-RACEMASE-RXN
xref: RHEA:13913
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018115
name: obsolete peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018116
name: obsolete peptidyl-lysine adenylylation
namespace: biological_process
def: "OBSOLETE. The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-lysine adenylation" EXACT []
is_obsolete: true

[Term]
id: GO:0018117
name: protein adenylylation
namespace: biological_process
alt_id: GO:0018176
def: "The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid." [GOC:ai, GOC:jsg, GOC:sart, PMID:21607083]
subset: gocheck_obsoletion_candidate
synonym: "protein adenylation" EXACT []
synonym: "protein amino acid adenylylation" EXACT [GOC:bf]
synonym: "protein AMPylation" EXACT [GOC:jsg, GOC:sart, PMID:21607083]
is_a: GO:0018175 ! protein nucleotidylation

[Term]
id: GO:0018118
name: obsolete peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018119
name: peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230]
subset: gocheck_obsoletion_candidate
synonym: "protein S-nitrosylation" EXACT [PMID:20972426]
synonym: "S-nitrosylation" EXACT [PMID:20972426]
xref: RESID:AA0230
is_a: GO:0017014 ! protein nitrosylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018120
name: obsolete peptidyl-arginine ADP-ribosylation
namespace: biological_process
def: "OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168]
comment: This term was obsoleted because it represents a molecular function.
xref: RESID:AA0168
is_obsolete: true
consider: GO:0106274

[Term]
id: GO:0018121
name: obsolete NAD(P)-asparagine ADP-ribosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [GOC:curators]
comment: This term was obsoleted because it doesn't correspond to a known reaction.
is_obsolete: true
consider: GO:1990404

[Term]
id: GO:0018122
name: obsolete peptidyl-asparagine ADP-ribosylation
namespace: biological_process
def: "OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018123
name: obsolete peptidyl-cysteine ADP-ribosylation
namespace: biological_process
def: "OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018124
name: obsolete peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone
namespace: biological_process
def: "OBSOLETE. The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0233
is_obsolete: true

[Term]
id: GO:0018125
name: peptidyl-cysteine methylation
namespace: biological_process
def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0234
is_a: GO:0006479 ! protein methylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018126
name: protein hydroxylation
namespace: biological_process
def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid hydroxylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018127
name: obsolete NAD(P)-serine ADP-ribosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [GOC:curators]
comment: This term was obsoleted because it represents the same reaction as NAD+-protein-serine ADP-ribosyltransferase activity ; GO:0140805.
is_obsolete: true
replaced_by: GO:0140805

[Term]
id: GO:0018128
name: obsolete peptidyl-serine cyclase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists.
synonym: "peptidyl-serine cyclase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018129
name: peptidyl-oxazoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reduction of a peptide-linked oxazoline to oxazole." [GOC:mah, PMID:19058272]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018130
name: obsolete heterocycle biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009058

[Term]
id: GO:0018131
name: oxazole or thiazole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [GOC:curators]
synonym: "oxazole or thiazole anabolism" EXACT []
synonym: "oxazole or thiazole biosynthesis" EXACT []
synonym: "oxazole or thiazole formation" EXACT []
synonym: "oxazole or thiazole synthesis" EXACT []
is_a: GO:0046484 ! oxazole or thiazole metabolic process

[Term]
id: GO:0018132
name: obsolete peptide cross-linking via L-cysteine oxazolecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0238
is_obsolete: true

[Term]
id: GO:0018133
name: obsolete peptide cross-linking via L-cysteine oxazolinecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0239
is_obsolete: true

[Term]
id: GO:0018134
name: obsolete peptide cross-linking via glycine oxazolecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0240
is_obsolete: true

[Term]
id: GO:0018135
name: obsolete peptidyl-cysteine cyclase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists.
synonym: "peptidyl-cysteine cyclase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018136
name: peptidyl-thiazoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reduction of a peptide-linked thiazoline to thiazole." [GOC:mah, PMID:19058272]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018137
name: obsolete peptide cross-linking via glycine thiazolecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0241
is_obsolete: true

[Term]
id: GO:0018138
name: obsolete peptide cross-linking via L-serine thiazolecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0242
is_obsolete: true

[Term]
id: GO:0018139
name: obsolete peptide cross-linking via L-phenylalanine thiazolecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0243
is_obsolete: true

[Term]
id: GO:0018140
name: obsolete peptide cross-linking via L-cysteine thiazolecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0244
is_obsolete: true

[Term]
id: GO:0018141
name: obsolete peptide cross-linking via L-lysine thiazolecarboxylic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0245
is_obsolete: true

[Term]
id: GO:0018142
name: obsolete protein-DNA covalent cross-linking
namespace: biological_process
def: "OBSOLETE. The formation of a covalent cross-link between DNA and a protein." [GOC:ma]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "DNA-protein covalent cross-linking" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0160129

[Term]
id: GO:0018143
name: nucleic acid-protein covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018144
name: RNA-protein covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma]
subset: gocheck_obsoletion_candidate
is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking

[Term]
id: GO:0018145
name: obsolete protein-DNA covalent cross-linking via peptidyl-serine
namespace: biological_process
def: "OBSOLETE. The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246]
comment: The reason for obsoletion is that is not known to be catalyzed by any gene product.
synonym: "DNA-protein covalent cross-linking via peptidyl-serine" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0018146
name: keratan sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247]
synonym: "keratan sulfate anabolism" EXACT []
synonym: "keratan sulfate biosynthesis" EXACT []
synonym: "keratan sulfate formation" EXACT []
synonym: "keratan sulfate synthesis" EXACT []
synonym: "keratan sulphate biosynthesis" EXACT []
synonym: "keratan sulphate biosynthetic process" EXACT []
xref: RESID:AA0247
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0042339 ! keratan sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0018147
name: obsolete molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "OBSOLETE. The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018148
name: obsolete RNA-protein covalent cross-linking via peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018149
name: peptide cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018150
name: obsolete peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0250
is_obsolete: true

[Term]
id: GO:0018151
name: obsolete peptide cross-linking via L-histidyl-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018152
name: obsolete peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0270
is_obsolete: true

[Term]
id: GO:0018153
name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0124
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0018154
name: obsolete peptide cross-linking via (2R,6R)-lanthionine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0110
is_obsolete: true

[Term]
id: GO:0018155
name: obsolete peptide cross-linking via sn-(2S,6R)-lanthionine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0111
is_obsolete: true

[Term]
id: GO:0018156
name: obsolete peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0112
is_obsolete: true

[Term]
id: GO:0018157
name: obsolete peptide cross-linking via an oxazole or thiazole
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
synonym: "peptide heterocycle biosynthesis" RELATED [GOC:mah]
synonym: "peptide heterocycle biosynthetic process" RELATED [GOC:mah]
synonym: "peptide heterocycle formation" RELATED [GOC:mah]
synonym: "peptide heterocycle synthesis" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0018158
name: protein oxidation
namespace: biological_process
def: "The modification of a protein amino acid by oxidation." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid oxidation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018159
name: obsolete peptidyl-methionine oxidation
namespace: biological_process
def: "OBSOLETE. The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018160
name: peptidyl-pyrromethane cofactor linkage
namespace: biological_process
alt_id: GO:0018354
alt_id: GO:0033035
def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [RESID:AA0252]
subset: gocheck_obsoletion_candidate
synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg]
synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg]
xref: RESID:AA0252
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018161
name: dipyrrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [PMID:17430001]
synonym: "dipyrrin anabolism" EXACT []
synonym: "dipyrrin biosynthesis" EXACT []
synonym: "dipyrrin formation" EXACT []
synonym: "dipyrrin synthesis" EXACT []
synonym: "dipyrromethane biosynthesis" EXACT []
synonym: "dipyrromethane biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0046453 ! dipyrrin metabolic process

[Term]
id: GO:0018162
name: obsolete peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine
namespace: biological_process
def: "OBSOLETE. The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0253
is_obsolete: true

[Term]
id: GO:0018163
name: obsolete protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254]
comment: The reason for obsoletion is that is not known to be catalyzed by any gene product.
synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0018164
name: obsolete protein-DNA covalent cross-linking via peptidyl-threonine
namespace: biological_process
def: "OBSOLETE. The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255]
comment: The reason for obsoletion is that is not known to be catalyzed by any gene product.
synonym: "DNA-protein covalent cross-linking via peptidyl-threonine" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0018165
name: obsolete peptidyl-tyrosine uridylylation
namespace: biological_process
def: "OBSOLETE. The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018166
name: obsolete C-terminal protein-tyrosinylation
namespace: biological_process
def: "OBSOLETE. The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
xref: RESID:AA0257
is_obsolete: true

[Term]
id: GO:0018167
name: obsolete protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine
namespace: biological_process
def: "OBSOLETE. The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018168
name: obsolete protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine
namespace: biological_process
def: "OBSOLETE. The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018169
name: ribosomal S6-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347]
is_a: GO:0070739 ! protein-glutamic acid ligase activity

[Term]
id: GO:0018170
name: obsolete C-terminal peptidyl-polyglutamic acid amidation
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261]
comment: This term was obsoleted because it represents a molecular function.
xref: RESID:AA0261
is_obsolete: true

[Term]
id: GO:0018171
name: peptidyl-cysteine oxidation
namespace: biological_process
def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0205
xref: RESID:AA0262
is_a: GO:0018158 ! protein oxidation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018172
name: obsolete peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT []
is_obsolete: true

[Term]
id: GO:0018173
name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [PMID:10660523, RESID:AA0265]
subset: gocheck_obsoletion_candidate
synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT []
xref: RESID:AA0265
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0042398 ! modified amino acid biosynthetic process
relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process

[Term]
id: GO:0018174
name: protein-heme P460 linkage
namespace: biological_process
def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271]
subset: gocheck_obsoletion_candidate
synonym: "protein-haem P460 linkage" EXACT []
xref: RESID:AA0266
xref: RESID:AA0271
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018175
name: protein nucleotidylation
namespace: biological_process
def: "The addition of a nucleotide to a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid nucleotidylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018177
name: protein uridylylation
namespace: biological_process
def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid uridylylation" EXACT [GOC:bf]
is_a: GO:0018175 ! protein nucleotidylation

[Term]
id: GO:0018178
name: obsolete peptidyl-threonine adenylylation
namespace: biological_process
def: "OBSOLETE. The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-threonine adenylation" EXACT []
is_obsolete: true

[Term]
id: GO:0018179
name: obsolete peptidyl-cysteine desulfurization
namespace: biological_process
def: "OBSOLETE. The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269]
comment: This term was made obsolete because to does not correspond to a real process.
synonym: "peptidyl-cysteine desulfurization" EXACT []
synonym: "peptidyl-cysteine desulphurization" EXACT []
xref: RESID:AA0269
is_obsolete: true

[Term]
id: GO:0018180
name: obsolete protein desulfurization
namespace: biological_process
def: "OBSOLETE. The removal of a sulfur group from a protein amino acid." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid desulfurisation" EXACT []
synonym: "protein amino acid desulfurization" EXACT [GOC:bf]
synonym: "protein amino acid desulphurisation" EXACT []
synonym: "protein amino acid desulphurization" EXACT []
is_obsolete: true

[Term]
id: GO:0018181
name: obsolete peptidyl-arginine C5-methylation
namespace: biological_process
def: "OBSOLETE. The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-arginine 5-methylation" EXACT []
xref: RESID:AA0272
is_obsolete: true
replaced_by: GO:0035244

[Term]
id: GO:0018182
name: obsolete protein-heme linkage via 3'-L-histidine
namespace: biological_process
def: "OBSOLETE. The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-haem linkage via 3'-L-histidine" EXACT []
is_obsolete: true

[Term]
id: GO:0018183
name: obsolete enzyme active site formation via S-selenyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277]
comment: This term was made obsolete because this structure does not exist.
synonym: "enzyme active site formation via S-selenyl-L-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018184
name: protein polyamination
namespace: biological_process
def: "The modification of a protein amino acid by polyamination." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid polyamination" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018185
name: obsolete poly-N-methyl-propylamination
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018186
name: peroxidase-heme linkage
namespace: biological_process
def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280]
subset: gocheck_obsoletion_candidate
synonym: "peroxidase-haem linkage" EXACT []
xref: RESID:AA0279
xref: RESID:AA0280
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018187
name: obsolete molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide
namespace: biological_process
def: "OBSOLETE. The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018188
name: peptidyl-proline di-hydroxylation
namespace: biological_process
def: "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0282
is_a: GO:0019511 ! peptidyl-proline hydroxylation

[Term]
id: GO:0018189
name: pyrroloquinoline quinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283]
synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT []
synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT []
synonym: "PQQ biosynthesis" EXACT []
synonym: "PQQ biosynthetic process" EXACT []
synonym: "pyrroloquinoline quinone anabolism" EXACT []
synonym: "pyrroloquinoline quinone biosynthesis" EXACT []
synonym: "pyrroloquinoline quinone formation" EXACT []
synonym: "pyrroloquinoline quinone synthesis" EXACT []
synonym: "pyrroloquinoline-quinone biosynthesis" EXACT []
synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT []
xref: RESID:AA0283
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process

[Term]
id: GO:0018190
name: protein octanoylation
namespace: biological_process
def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid octanoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018191
name: peptidyl-serine octanoylation
namespace: biological_process
def: "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0290
is_a: GO:0018190 ! protein octanoylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018192
name: obsolete enzyme active site formation via cysteine modification to L-cysteine persulfide
namespace: biological_process
def: "OBSOLETE. The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [RESID:AA0269]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:11592406.
synonym: "enzyme active site formation via L-cysteine persulphide" EXACT []
is_obsolete: true
consider: GO:0004792

[Term]
id: GO:0018193
name: peptidyl-amino acid modification
namespace: biological_process
def: "The alteration of an amino acid residue in a peptide." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_yeast
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018194
name: peptidyl-alanine modification
namespace: biological_process
def: "The modification of peptidyl-alanine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018195
name: peptidyl-arginine modification
namespace: biological_process
def: "The modification of peptidyl-arginine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018196
name: obsolete peptidyl-asparagine modification
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-asparagine." [GOC:go_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018197
name: peptidyl-aspartic acid modification
namespace: biological_process
def: "The modification of peptidyl-aspartic acid." [GOC:ma]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018198
name: peptidyl-cysteine modification
namespace: biological_process
def: "The modification of peptidyl-cysteine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018199
name: peptidyl-glutamine modification
namespace: biological_process
def: "The modification of peptidyl-glutamine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018200
name: peptidyl-glutamic acid modification
namespace: biological_process
def: "The modification of peptidyl-glutamic acid." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018201
name: peptidyl-glycine modification
namespace: biological_process
def: "The modification of peptidyl-glycine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018202
name: peptidyl-histidine modification
namespace: biological_process
def: "The modification of peptidyl-histidine." [GOC:ma]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018203
name: peptidyl-isoleucine modification
namespace: biological_process
def: "The modification of peptidyl-isoleucine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018204
name: peptidyl-leucine modification
namespace: biological_process
def: "The modification of peptidyl-leucine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018205
name: peptidyl-lysine modification
namespace: biological_process
def: "The modification of peptidyl-lysine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018206
name: peptidyl-methionine modification
namespace: biological_process
def: "The modification of peptidyl-methionine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018207
name: peptidyl-phenylalanine modification
namespace: biological_process
def: "The modification of peptidyl-phenylalanine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018208
name: peptidyl-proline modification
namespace: biological_process
def: "The modification of peptidyl-proline." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018209
name: peptidyl-serine modification
namespace: biological_process
def: "The modification of peptidyl-serine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018210
name: peptidyl-threonine modification
namespace: biological_process
def: "The modification of peptidyl-threonine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018211
name: peptidyl-tryptophan modification
namespace: biological_process
def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018212
name: peptidyl-tyrosine modification
namespace: biological_process
def: "The modification of peptidyl-tyrosine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018213
name: peptidyl-valine modification
namespace: biological_process
def: "The modification of peptidyl-valine." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018214
name: protein carboxylation
namespace: biological_process
def: "The addition of a carboxy group to a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid carboxylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018215
name: protein phosphopantetheinylation
namespace: biological_process
def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid phosphopantetheinylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018216
name: peptidyl-arginine methylation
namespace: biological_process
alt_id: GO:0018017
def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006479 ! protein methylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018217
name: peptidyl-aspartic acid phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-aspartic acid." [GOC:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0018218
name: obsolete peptidyl-cysteine phosphorylation
namespace: biological_process
def: "OBSOLETE. The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018219
name: obsolete peptidyl-cysteine S-acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018220
name: obsolete peptidyl-threonine palmitoylation
namespace: biological_process
def: "OBSOLETE. The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-threonine O-palmitoylation" EXACT [GOC:jsg]
is_obsolete: true

[Term]
id: GO:0018221
name: obsolete peptidyl-serine palmitoylation
namespace: biological_process
def: "OBSOLETE. The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine." [RESID:AA0080]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-serine O-palmitoylation" EXACT [GOC:jsg]
is_obsolete: true

[Term]
id: GO:0018222
name: obsolete peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018226
name: obsolete peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018227
name: obsolete peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018228
name: obsolete peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018229
name: obsolete peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018230
name: peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106]
comment: Palmitoylation of a non-terminal cysteine residue always occurs on a sulfur (S) atom.
subset: gocheck_obsoletion_candidate
synonym: "peptidyl-cysteine S-palmitoylation" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0106
is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
is_a: GO:0018345 ! protein palmitoylation

[Term]
id: GO:0018231
name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107]
subset: gocheck_do_not_annotate
synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0107
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018232
name: obsolete peptide cross-linking via S-(L-isoglutamyl)-L-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
xref: RESID:AA0108
is_obsolete: true

[Term]
id: GO:0018233
name: obsolete peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0109
is_obsolete: true

[Term]
id: GO:0018234
name: obsolete peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0113
is_obsolete: true

[Term]
id: GO:0018235
name: obsolete peptidyl-lysine carboxylation
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018237
name: urease activator activity
namespace: molecular_function
def: "Increases the activity of urease by promoting the incorporation of nickel into the active site." [GOC:mah, PMID:16244137]
synonym: "urease activase activity" EXACT []
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0018238
name: obsolete peptidyl-lysine carboxyethylation
namespace: biological_process
alt_id: GO:0018239
def: "OBSOLETE. The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid carboxyethylation" EXACT []
is_obsolete: true

[Term]
id: GO:0018240
name: protein S-linked glycosylation via cysteine
namespace: biological_process
def: "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid S-linked glycosylation via cysteine" EXACT [GOC:bf]
xref: RESID:AA0152
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018280 ! protein S-linked glycosylation

[Term]
id: GO:0018241
name: protein O-linked glycosylation via hydroxylysine
namespace: biological_process
def: "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153]
synonym: "protein amino acid O-linked glycosylation via hydroxylysine" EXACT [GOC:bf]
xref: RESID:AA0153
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018242
name: protein O-linked glycosylation via serine
namespace: biological_process
def: "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154]
synonym: "protein amino acid O-linked glycosylation via serine" EXACT [GOC:bf]
xref: RESID:AA0154
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018243
name: protein O-linked glycosylation via threonine
namespace: biological_process
def: "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155]
synonym: "protein amino acid O-linked glycosylation via threonine" EXACT [GOC:bf]
xref: RESID:AA0155
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018244
name: obsolete protein N-linked glycosylation via tryptophan
namespace: biological_process
def: "OBSOLETE. The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue." [RESID:AA0156]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0006487

[Term]
id: GO:0018245
name: protein O-linked glycosylation via tyrosine
namespace: biological_process
def: "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157]
synonym: "protein amino acid O-linked glycosylation via tyrosine" EXACT [GOC:bf]
xref: RESID:AA0157
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018246
name: protein-coenzyme A linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018247
name: protein-phosphoribosyl dephospho-coenzyme A linkage
namespace: biological_process
def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0167
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018246 ! protein-coenzyme A linkage

[Term]
id: GO:0018248
name: obsolete enzyme active site formation via peptidyl cysteine sulfation
namespace: biological_process
def: "OBSOLETE. The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171]
comment: This term was obsoleted because it was created by error: cysteine sulfation is a post-translational modification, see PMID:12876326.
synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018249
name: protein dehydration
namespace: biological_process
def: "The removal of a water group from a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid dehydration" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018250
name: obsolete peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine
namespace: biological_process
def: "OBSOLETE. The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT []
synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT []
synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT []
is_obsolete: true

[Term]
id: GO:0018251
name: peptidyl-tyrosine dehydrogenation
namespace: biological_process
def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183]
comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'.
subset: gocheck_obsoletion_candidate
xref: RESID:AA0183
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018249 ! protein dehydration

[Term]
id: GO:0018252
name: obsolete peptide cross-linking via L-seryl-5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0184
is_obsolete: true

[Term]
id: GO:0018253
name: obsolete peptide cross-linking via 5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT []
xref: RESID:AA0184
xref: RESID:AA0187
xref: RESID:AA0188
is_obsolete: true

[Term]
id: GO:0018254
name: obsolete peptidyl-tyrosine adenylylation
namespace: biological_process
def: "OBSOLETE. The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-tyrosine adenylation" EXACT []
is_obsolete: true

[Term]
id: GO:0018255
name: obsolete peptide cross-linking via S-glycyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [GOC:jh2, RESID:AA0206]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018256
name: protein formylation
namespace: biological_process
def: "The addition of a formyl group to a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid formylation" EXACT [GOC:bf]
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018257
name: obsolete peptidyl-lysine formylation
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018258
name: protein O-linked glycosylation via hydroxyproline
namespace: biological_process
def: "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212]
synonym: "protein amino acid O-linked glycosylation via hydroxyproline" EXACT [GOC:bf]
xref: RESID:AA0212
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0018259
name: RNA-protein covalent cross-linking via peptidyl-serine
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0213
is_a: GO:0018144 ! RNA-protein covalent cross-linking
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018260
name: protein guanylylation
namespace: biological_process
def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid guanylylation" EXACT [GOC:bf]
is_a: GO:0018175 ! protein nucleotidylation

[Term]
id: GO:0018261
name: obsolete peptidyl-lysine guanylylation
namespace: biological_process
def: "OBSOLETE. The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018262
name: isopeptide cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg]
subset: gocheck_obsoletion_candidate
is_a: GO:0018149 ! peptide cross-linking

[Term]
id: GO:0018263
name: obsolete isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine
namespace: biological_process
def: "OBSOLETE. The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018264
name: obsolete isopeptide cross-linking via N-(L-isoaspartyl)-glycine
namespace: biological_process
def: "OBSOLETE. The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018265
name: obsolete GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0018266
name: obsolete GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0018267
name: obsolete GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0018268
name: obsolete GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0018269
name: obsolete GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0018270
name: obsolete GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0018271
name: obsolete biotin-protein ligase activity
namespace: molecular_function
alt_id: GO:0000106
def: "OBSOLETE. Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah]
comment: The reason for obsoletion is this term is an unnecessary grouping term.
synonym: "biotin-apoprotein ligase activity" EXACT []
xref: Reactome:R-HSA-2993447 "HLCS biotinylates 6x(PCCA:PCCB)"
xref: Reactome:R-HSA-2993799 "HLCS biotinylates 6xMCCC1:6xMCCC2"
xref: Reactome:R-HSA-2993802 "HLCS biotinylates PC:Mn2+"
xref: Reactome:R-HSA-2993814 "HLCS biotinylates ACACA:Mn2+"
xref: Reactome:R-HSA-3323184 "Defective HLCS does not biotinylate ACACA:Mn2+"
xref: Reactome:R-HSA-4167511 "HLCS biotinylates ACACB"
xref: Reactome:R-HSA-9035987 "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2"
xref: Reactome:R-HSA-9035988 "Defective HLCS does not biotinylate PC:Mn2+"
xref: Reactome:R-HSA-9035990 "Defective HLCS does not biotinylate 6x(PCCA:PCCB)"
is_obsolete: true
replaced_by: GO:0004077

[Term]
id: GO:0018272
name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
namespace: biological_process
def: "The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0119
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage

[Term]
id: GO:0018273
name: obsolete protein-chromophore linkage via peptidyl-N6-retinal-L-lysine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120]
comment: Term describes modified products or self-catalyzed processes.
xref: RESID:AA0120
is_obsolete: true

[Term]
id: GO:0018274
name: obsolete peptide cross-linking via L-lysinoalanine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0123
is_obsolete: true

[Term]
id: GO:0018275
name: obsolete N-terminal peptidyl-cysteine acetylation
namespace: biological_process
alt_id: GO:0017191
def: "OBSOLETE. The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-cysteine N-acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0018276
name: obsolete isopeptide cross-linking via N6-glycyl-L-lysine
namespace: biological_process
def: "OBSOLETE. The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018277
name: protein deamination
namespace: biological_process
def: "The removal of an amino group from a protein amino acid." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid deamination" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018278
name: obsolete N-terminal peptidyl-threonine deamination
namespace: biological_process
def: "OBSOLETE. The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018279
name: protein N-linked glycosylation via asparagine
namespace: biological_process
def: "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]
synonym: "protein amino acid N-linked glycosylation via asparagine" EXACT [GOC:bf]
is_a: GO:0006487 ! protein N-linked glycosylation

[Term]
id: GO:0018280
name: protein S-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg, GOC:pr]
synonym: "protein amino acid S-linked glycosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0018281
name: obsolete GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166]
comment: This term was obsoleted because it represents a molecular function.
synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
is_obsolete: true

[Term]
id: GO:0018282
name: metal incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg]
subset: gocheck_obsoletion_candidate
synonym: "metal incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0036211 ! protein modification process
relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly

[Term]
id: GO:0018283
name: iron incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "iron incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018284
name: obsolete iron incorporation into protein via tetrakis-L-cysteinyl iron
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018285
name: obsolete iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018286
name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138]
comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form.
synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide" EXACT []
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT []
is_obsolete: true
consider: GO:0018198
consider: GO:0018283

[Term]
id: GO:0018287
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018288
name: obsolete iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018289
name: molybdenum incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018290
name: obsolete iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018291
name: molybdenum incorporation into iron-sulfur cluster
namespace: biological_process
def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster

[Term]
id: GO:0018292
name: obsolete molybdenum incorporation via L-cysteinyl molybdopterin
namespace: biological_process
def: "OBSOLETE. The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018293
name: protein-FAD linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018294
name: obsolete protein-FAD linkage via S-(8alpha-FAD)-L-cysteine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018295
name: obsolete protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018296
name: obsolete protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018297
name: obsolete protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018298
name: obsolete protein-chromophore linkage
namespace: biological_process
def: "OBSOLETE. The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
comment: Term describes modified products or self-catalyzed processes.
is_obsolete: true

[Term]
id: GO:0018299
name: obsolete iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018300
name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226]
comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist.
synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide" EXACT []
synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT []
is_obsolete: true
consider: GO:0018198
consider: GO:0018283

[Term]
id: GO:0018301
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT []
is_obsolete: true

[Term]
id: GO:0018302
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018303
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018304
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018305
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018306
name: obsolete iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018307
name: obsolete enzyme active site formation
namespace: biological_process
def: "OBSOLETE. The modification of part of an enzyme to form the active site." [GOC:ai]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see https://en.wikipedia.org/wiki/Active_site#Mechanisms_involved_in_Catalytic_process.
is_obsolete: true

[Term]
id: GO:0018308
name: obsolete enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine
namespace: biological_process
def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287]
comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site.
synonym: "enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine" EXACT []
is_obsolete: true

[Term]
id: GO:0018309
name: obsolete protein-FMN linkage
namespace: biological_process
def: "OBSOLETE. The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah]
comment: This is a molecular function.
is_obsolete: true

[Term]
id: GO:0018310
name: obsolete protein-FMN linkage via S-(6-FMN)-L-cysteine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220]
comment: This is a molecular function.
xref: RESID:AA0220
is_obsolete: true

[Term]
id: GO:0018311
name: obsolete peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT []
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT []
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT []
is_obsolete: true

[Term]
id: GO:0018312
name: obsolete peptidyl-serine ADP-ribosylation
namespace: biological_process
def: "OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018313
name: obsolete peptide cross-linking via L-alanyl-5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0187
is_obsolete: true

[Term]
id: GO:0018314
name: obsolete protein-pyrroloquinoline-quinone linkage
namespace: biological_process
def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283]
synonym: "protein-pyrroloquinoline-quinone linkage" EXACT []
is_obsolete: true

[Term]
id: GO:0018315
name: molybdenum incorporation into molybdenum-molybdopterin complex
namespace: biological_process
alt_id: GO:0042041
def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "molybdenum incorporation into metallo-pterin complex" EXACT []
is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex

[Term]
id: GO:0018316
name: peptide cross-linking via L-cystine
namespace: biological_process
def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0025
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018317
name: protein C-linked glycosylation via tryptophan
namespace: biological_process
def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid C-linked glycosylation via tryptophan" EXACT [GOC:bf]
is_a: GO:0018103 ! protein C-linked glycosylation
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018320
name: obsolete enzyme active site formation via S-methyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:21527678.
xref: RESID:AA0234
is_obsolete: true
consider: GO:0008757

[Term]
id: GO:0018321
name: protein glucuronylation
namespace: biological_process
def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai, GOC:pr]
synonym: "protein amino acid glucuronylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0018322
name: obsolete protein tyrosinylation
namespace: biological_process
def: "OBSOLETE. The addition of a tyrosine molecule to a protein amino acid." [GOC:ai]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
synonym: "protein amino acid tyrosinylation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0018323
name: obsolete enzyme active site formation via L-cysteine sulfinic acid
namespace: biological_process
def: "OBSOLETE. The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:9586994.
synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT []
xref: RESID:AA0262
is_obsolete: true
consider: GO:0018822

[Term]
id: GO:0018324
name: obsolete enzyme active site formation via L-cysteine sulfenic acid
namespace: biological_process
def: "OBSOLETE. The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:10964927 and PMID:9587003.
synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT []
xref: RESID:AA0205
is_obsolete: true

[Term]
id: GO:0018325
name: obsolete enzyme active site formation via S-phospho-L-cysteine
namespace: biological_process
def: "OBSOLETE. The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:3142516 and PMID:22927394.
xref: RESID:AA0034
is_obsolete: true

[Term]
id: GO:0018326
name: obsolete enzyme active site formation via S-acetyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:1310545.
xref: RESID:AA0056
is_obsolete: true

[Term]
id: GO:0018327
name: obsolete enzyme active site formation via 1'-phospho-L-histidine
namespace: biological_process
def: "OBSOLETE. The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:11038361.
xref: RESID:AA0035
is_obsolete: true
consider: GO:0008257

[Term]
id: GO:0018328
name: obsolete enzyme active site formation via 3'-phospho-L-histidine
namespace: biological_process
def: "OBSOLETE. The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:11168390.
xref: RESID:AA0036
is_obsolete: true
consider: GO:0008256

[Term]
id: GO:0018329
name: obsolete enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine
namespace: biological_process
def: "OBSOLETE. The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:4944632 and and PMID:3882425.
xref: RESID:AA0227
is_obsolete: true
consider: GO:0003910

[Term]
id: GO:0018330
name: obsolete enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine
namespace: biological_process
def: "OBSOLETE. The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:6092377.
xref: RESID:AA0228
is_obsolete: true
consider: GO:0070568

[Term]
id: GO:0018331
name: obsolete enzyme active site formation via O-phospho-L-serine
namespace: biological_process
def: "OBSOLETE. The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:8061611 and PMID:12923550.
xref: RESID:AA0037
is_obsolete: true

[Term]
id: GO:0018332
name: obsolete enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine
namespace: biological_process
def: "OBSOLETE. The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:19039103 and PMID:19503829.
xref: RESID:AA0267
is_obsolete: true

[Term]
id: GO:0018333
name: obsolete enzyme active site formation via O-phospho-L-threonine
namespace: biological_process
def: "OBSOLETE. The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038]
comment: This term was obsoleted because it was created by error: tyrosine phosphorylation does not generate an active site.
xref: RESID:AA0038
is_obsolete: true

[Term]
id: GO:0018334
name: obsolete enzyme active site formation via O4'-phospho-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039]
comment: This term was obsoleted because it was created by error: O4'-phospho-L-tyrosine is a post-translational modification, see PMID:1725475.
xref: RESID:AA0039
is_obsolete: true

[Term]
id: GO:0018335
name: protein succinylation
namespace: biological_process
def: "The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue." [GOC:bf]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid succinylation" EXACT [GOC:bf]
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018336
name: peptidyl-tyrosine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0018126 ! protein hydroxylation

[Term]
id: GO:0018337
name: obsolete enzyme active site formation via L-2',4',5'-topaquinone
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site.
synonym: "enzyme active site formation via L-2',4',5'-topaquinone" EXACT []
is_obsolete: true

[Term]
id: GO:0018338
name: obsolete protein amino acid cinnamylation
namespace: biological_process
def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term. Consider GO:0018097 has been obsoleted.
synonym: "protein amino acid cinnamylation" EXACT []
is_obsolete: true

[Term]
id: GO:0018339
name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232]
subset: gocheck_do_not_annotate
synonym: "peptidyl-aspartic acid methylthiolation" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT []
xref: RESID:AA0232
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018340
name: obsolete peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT []
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT []
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT []
is_obsolete: true

[Term]
id: GO:0018341
name: obsolete peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine." [PSI-MOD:00292]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0018342
name: protein prenylation
namespace: biological_process
alt_id: GO:0018346
def: "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]
subset: gocheck_obsoletion_candidate
synonym: "C-terminal protein prenylation" NARROW []
synonym: "protein amino acid prenylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process
is_a: GO:0097354 ! prenylation

[Term]
id: GO:0018343
name: protein farnesylation
namespace: biological_process
alt_id: GO:0018347
def: "The covalent attachment of a farnesyl group to a protein." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "C-terminal protein farnesylation" NARROW []
synonym: "protein amino acid farnesylation" EXACT [GOC:bf]
is_a: GO:0018342 ! protein prenylation

[Term]
id: GO:0018344
name: protein geranylgeranylation
namespace: biological_process
alt_id: GO:0018348
def: "The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "C-terminal protein geranylgeranylation" NARROW []
synonym: "protein amino acid geranylgeranylation" EXACT [GOC:bf]
is_a: GO:0018342 ! protein prenylation

[Term]
id: GO:0018345
name: protein palmitoylation
namespace: biological_process
alt_id: GO:0018318
alt_id: GO:0018349
def: "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid palmitoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018350
name: obsolete protein esterification
namespace: biological_process
def: "OBSOLETE. The addition of an ester group to a protein amino acid." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid esterification" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0018351
name: obsolete peptidyl-cysteine esterification
namespace: biological_process
def: "OBSOLETE. The addition of an ester group to a cysteine residue in a protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018352
name: protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018353
name: obsolete protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine
namespace: biological_process
alt_id: GO:0018380
def: "OBSOLETE. The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018355
name: obsolete protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [RESID:AA0167]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018356
name: obsolete protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine
namespace: biological_process
alt_id: GO:0018382
def: "OBSOLETE. The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018357
name: obsolete protein-phycourobilin linkage via phycourobilin-bis-L-cysteine
namespace: biological_process
alt_id: GO:0018383
def: "OBSOLETE. The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018358
name: obsolete protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine
namespace: biological_process
alt_id: GO:0018381
def: "OBSOLETE. The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018359
name: obsolete protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine
namespace: biological_process
alt_id: GO:0018385
def: "OBSOLETE. The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT []
is_obsolete: true

[Term]
id: GO:0018360
name: obsolete protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine
namespace: biological_process
alt_id: GO:0018384
def: "OBSOLETE. The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT []
is_obsolete: true

[Term]
id: GO:0018361
name: obsolete peptidyl-glutamine 2-methylation
namespace: biological_process
def: "OBSOLETE. The methylation of glutamine to form 2-methyl-L-glutamine." [https://en.wikipedia.org/wiki/N-Methyl-L-glutamic_acid, PMID:10660523, RESID:AA0273]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018362
name: obsolete peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester
namespace: biological_process
alt_id: GO:0019924
def: "OBSOLETE. The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT []
is_obsolete: true

[Term]
id: GO:0018363
name: obsolete peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium
namespace: biological_process
alt_id: GO:0019925
def: "OBSOLETE. The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT []
synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT []
is_obsolete: true

[Term]
id: GO:0018364
name: peptidyl-glutamine methylation
namespace: biological_process
def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006479 ! protein methylation

[Term]
id: GO:0018365
name: protein-serine epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16]
synonym: "protein-serine racemase activity" RELATED [EC:5.1.1.16]
xref: EC:5.1.1.16
xref: MetaCyc:5.1.1.16-RXN
xref: RHEA:10660
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0018366
name: chiral amino acid racemization
namespace: biological_process
def: "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732]
is_a: GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0018367
name: obsolete free L-amino acid racemization
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is not clear that this process occurs.
synonym: "free L-amino acid racemization" EXACT []
is_obsolete: true
consider: GO:0006520

[Term]
id: GO:0018376
name: obsolete peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026]
comment: This term was obsoleted because it represents a molecular function.
xref: RESID:AA0026
is_obsolete: true
replaced_by: GO:0062101

[Term]
id: GO:0018377
name: protein myristoylation
namespace: biological_process
alt_id: GO:0018319
def: "The covalent attachment of a myristoyl group to a protein." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid myristoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018378
name: obsolete cytochrome c-heme linkage via heme-L-cysteine
namespace: biological_process
def: "OBSOLETE. The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018379
name: obsolete cytochrome c-heme linkage via heme-bis-L-cysteine
namespace: biological_process
def: "OBSOLETE. The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018386
name: obsolete N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018387
name: obsolete N-terminal peptidyl-amino acid deamination to pyruvic acid
namespace: biological_process
def: "OBSOLETE. The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018388
name: obsolete N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine
namespace: biological_process
def: "OBSOLETE. The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018389
name: obsolete N-terminal peptidyl-valine deamination
namespace: biological_process
def: "OBSOLETE. The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018390
name: obsolete peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine
namespace: biological_process
def: "OBSOLETE. The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
is_obsolete: true

[Term]
id: GO:0018391
name: obsolete C-terminal peptidyl-glutamic acid tyrosinylation
namespace: biological_process
def: "OBSOLETE. The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein." [GOC:mah]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
is_obsolete: true

[Term]
id: GO:0018392
name: glycoprotein 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H+." [EC:2.4.1.214, RHEA:24444]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT []
synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" RELATED [EC:2.4.1.214]
synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" RELATED [EC:2.4.1.214]
xref: EC:2.4.1.214
xref: KEGG_REACTION:R06015
xref: MetaCyc:2.4.1.214-RXN
xref: RHEA:24444
is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0018393
name: internal peptidyl-lysine acetylation
namespace: biological_process
def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006475 ! internal protein amino acid acetylation
is_a: GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:0018394
name: peptidyl-lysine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-lysine." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006473 ! protein acetylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018395
name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0028
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0018396
name: obsolete peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018397
name: obsolete peptidyl-phenylalanine bromination to L-2'-bromophenylalanine
namespace: biological_process
def: "OBSOLETE. The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174]
xref: RESID:AA0174
is_obsolete: true

[Term]
id: GO:0018398
name: obsolete peptidyl-phenylalanine bromination to L-3'-bromophenylalanine
namespace: biological_process
def: "OBSOLETE. The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175]
xref: RESID:AA0175
is_obsolete: true

[Term]
id: GO:0018399
name: obsolete peptidyl-phenylalanine bromination to L-4'-bromophenylalanine
namespace: biological_process
def: "OBSOLETE. The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176]
xref: RESID:AA0176
is_obsolete: true

[Term]
id: GO:0018400
name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline
namespace: biological_process
def: "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029]
comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'.
subset: gocheck_obsoletion_candidate
xref: RESID:AA0029
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0019511 ! peptidyl-proline hydroxylation
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0018401
name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline
namespace: biological_process
def: "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]
comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'.
subset: gocheck_obsoletion_candidate
xref: RESID:AA0030
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0019511 ! peptidyl-proline hydroxylation
is_a: GO:0170033 ! L-amino acid metabolic process

[Term]
id: GO:0018402
name: obsolete protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "OBSOLETE. Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
is_obsolete: true

[Term]
id: GO:0018403
name: obsolete protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "OBSOLETE. Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
is_obsolete: true

[Term]
id: GO:0018404
name: obsolete protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "OBSOLETE. Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
is_obsolete: true

[Term]
id: GO:0018405
name: obsolete protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine
namespace: biological_process
def: "OBSOLETE. Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT []
is_obsolete: true

[Term]
id: GO:0018406
name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
namespace: biological_process
alt_id: GO:0032004
def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan" EXACT [GOC:bf]
synonym: "protein amino acid C-linked mannosylation" EXACT []
xref: RESID:AA0217
is_a: GO:0018317 ! protein C-linked glycosylation via tryptophan
is_a: GO:0035268 ! protein mannosylation

[Term]
id: GO:0018407
name: obsolete peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine
namespace: biological_process
def: "OBSOLETE. The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177]
synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD []
xref: RESID:AA0177
is_obsolete: true

[Term]
id: GO:0018408
name: obsolete peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine
namespace: biological_process
def: "OBSOLETE. The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178]
xref: RESID:AA0178
is_obsolete: true

[Term]
id: GO:0018410
name: C-terminal protein amino acid modification
namespace: biological_process
def: "The alteration of the C-terminal amino acid residue in a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "peptide or protein carboxyl-terminal blocking" RELATED []
synonym: "peptide/protein carboxyl-terminal blocking" RELATED []
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018411
name: protein glucuronidation
namespace: biological_process
def: "The modification of a protein by amino acid glucuronidation." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid glucuronidation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0018412
name: protein O-glucuronidation
namespace: biological_process
def: "The modification of a protein by glucuronidation on an amino acid oxygen atom." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid O-glucuronidation" EXACT [GOC:bf]
is_a: GO:0018411 ! protein glucuronidation

[Term]
id: GO:0018413
name: obsolete peptidyl-serine O-glucuronidation
namespace: biological_process
def: "OBSOLETE. The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018414
name: nickel incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "nickel incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018415
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT []
is_obsolete: true

[Term]
id: GO:0018416
name: obsolete nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide
namespace: biological_process
def: "OBSOLETE. The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]
comment: This term was obsoleted because it represents a molecular function.
synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT []
is_obsolete: true

[Term]
id: GO:0018417
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT []
is_obsolete: true

[Term]
id: GO:0018418
name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]
subset: gocheck_obsoletion_candidate
synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0293
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster

[Term]
id: GO:0018419
name: protein catenane formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0018420
name: obsolete peptide cross-linking via N6-(L-isoaspartyl)-L-lysine
namespace: biological_process
def: "OBSOLETE. The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018421
name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:9353330]
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0018422
name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:10037765]
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0018423
name: protein C-terminal leucine carboxyl O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + [protein]-L-leucine = S-adenosyl-L-homocysteine + [protein]-L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774]
synonym: "protein phosphatase methyltransferase activity" NARROW []
synonym: "protein-leucine O-methyltransferase activity" EXACT []
xref: Reactome:R-HSA-8856945 "PP2A methylation by LCMT1"
is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018424
name: obsolete peptidyl-glutamic acid poly-ADP-ribosylation
namespace: biological_process
def: "OBSOLETE. This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295]
comment: This term was obsoleted because it represents a molecular function.
xref: RESID:AA0295
is_obsolete: true
consider: GO:0140807

[Term]
id: GO:0018425
name: obsolete O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296]
comment: This term was obsoleted because it represents a molecular function.
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0018426
name: obsolete O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-phosphate-Ser linkage." [RESID:AA0297]
comment: This term was obsoleted because it represents a molecular function.
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0018427
name: copper incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "copper incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018428
name: copper incorporation into copper-sulfur cluster
namespace: biological_process
def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "copper incorporation into copper-sulphur cluster" EXACT []
is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster

[Term]
id: GO:0018429
name: obsolete copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide
namespace: biological_process
def: "OBSOLETE. The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298]
comment: This term was obsoleted because it represents a molecular function.
synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT []
is_obsolete: true

[Term]
id: GO:0018439
name: obsolete peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine
namespace: biological_process
alt_id: GO:0018440
def: "OBSOLETE. The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester." [RESID:AA0299]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-leucine esterification" EXACT []
is_obsolete: true

[Term]
id: GO:0018441
name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0018442
name: obsolete peptidyl-glutamic acid esterification
namespace: biological_process
def: "OBSOLETE. The addition of an ester group to a glutamic acid residue in a protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0018443
name: obsolete enzyme active site formation via L-aspartic 4-phosphoric anhydride
namespace: biological_process
def: "OBSOLETE. The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:4357737.
xref: RESID:AA0033
is_obsolete: true

[Term]
id: GO:0018444
name: translation release factor complex
namespace: cellular_component
def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
synonym: "eukaryotic peptide chain release factor" EXACT []
synonym: "peptide chain release factor" BROAD []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0018445
name: prothoracicotrophic hormone activity
namespace: molecular_function
def: "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0018446
name: obsolete pinocarveol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018447
name: obsolete chloral hydrate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018448
name: obsolete hydroxymethylmethylsilanediol oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018449
name: 1-phenylethanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-1-phenylethanol + NAD+ = acetophenone + H+ + NADH." [RHEA:28198]
xref: EC:1.1.1.311
xref: RHEA:28198
xref: UM-BBD_reactionID:r0032
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018450
name: obsolete myrtenol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018451
name: obsolete epoxide dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018452
name: 5-exo-hydroxycamphor dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427]
xref: EC:1.1.1.327
xref: MetaCyc:R542-RXN
xref: RHEA:32879
xref: UM-BBD_reactionID:r0427
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018453
name: obsolete 2-hydroxytetrahydrofuran dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018454
name: acetoacetyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36]
synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" RELATED [EC:1.1.1.36]
synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.36]
synonym: "acetoacetyl coenzyme A reductase activity" RELATED [EC:1.1.1.36]
synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36]
synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" RELATED [EC:1.1.1.36]
synonym: "D-3-hydroxyacyl-CoA reductase activity" RELATED [EC:1.1.1.36]
synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" RELATED [EC:1.1.1.36]
synonym: "NADP-linked acetoacetyl CoA reductase activity" RELATED [EC:1.1.1.36]
synonym: "NADPH:acetoacetyl-CoA reductase activity" RELATED [EC:1.1.1.36]
synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" RELATED [EC:1.1.1.36]
xref: EC:1.1.1.36
xref: RHEA:22256
xref: UM-BBD_reactionID:r0202
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018455
name: alcohol dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde or ketone + NAD(P)H + H+." [GOC:curators]
synonym: "alcohol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.71]
synonym: "aldehyde reductase (NADPH/NADH)" RELATED [EC:1.1.1.71]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018456
name: aryl-alcohol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90]
synonym: "aryl-alcohol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.90]
synonym: "benzyl alcohol dehydrogenase activity" NARROW []
synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90]
xref: EC:1.1.1.90
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN
xref: RHEA:12076
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0018457
name: perillyl-alcohol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + perillyl alcohol = H+ + NADH + perillyl aldehyde." [EC:1.1.1.144, RHEA:10664]
synonym: "perillyl alcohol dehydrogenase activity" RELATED [EC:1.1.1.144]
synonym: "perillyl-alcohol dehydrogenase activity" BROAD []
synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.144]
xref: EC:1.1.1.144
xref: KEGG_REACTION:R03945
xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN
xref: RHEA:10664
xref: UM-BBD_reactionID:r0729
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0018458
name: isopiperitenol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD+ = (6R)-isoperitenone + H+ + NADH." [EC:1.1.1.223, RHEA:20860]
synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.223]
xref: EC:1.1.1.223
xref: KEGG_REACTION:R03261
xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN
xref: RHEA:20860
xref: UM-BBD_reactionID:r0740
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018459
name: carveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,5R)-carveol + NADP+ = (R)-carvone + H+ + NADPH." [EC:1.1.1.243, RHEA:13629]
synonym: "(-)-trans-carveol dehydrogenase activity" RELATED [EC:1.1.1.243]
synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.243]
xref: EC:1.1.1.243
xref: KEGG_REACTION:R03114
xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN
xref: RHEA:13629
xref: UM-BBD_reactionID:r0714
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018460
name: cyclohexanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245]
synonym: "cyclohexanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.245]
xref: EC:1.1.1.245
xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN
xref: RHEA:10044
xref: UM-BBD_reactionID:r0165
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018461
name: fluoren-9-ol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256]
synonym: "9-fluorenol dehydrogenase activity" EXACT []
synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.256]
xref: EC:1.1.1.256
xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN
xref: UM-BBD_reactionID:r0408
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018462
name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + H+ + NADH." [EC:1.1.1.257, RHEA:24412]
synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.257]
synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT []
synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT []
xref: EC:1.1.1.257
xref: KEGG_REACTION:R05271
xref: MetaCyc:SOLDEHYD-RXN
xref: RHEA:24412
xref: UM-BBD_reactionID:r0291
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018463
name: 6-hydroxyhexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + H+ + NADH." [EC:1.1.1.258, RHEA:14225]
synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.258]
xref: EC:1.1.1.258
xref: KEGG_REACTION:R05283
xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN
xref: RHEA:14225
xref: UM-BBD_reactionID:r0174
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018464
name: 3-hydroxypimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD+ = 3-oxopimelyl-CoA + H+ + NADH." [EC:1.1.1.259, RHEA:11168]
synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.259]
xref: EC:1.1.1.259
xref: KEGG_REACTION:R05305
xref: MetaCyc:1.1.1.259-RXN
xref: RHEA:11168
xref: UM-BBD_reactionID:r0196
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018465
name: vanillyl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + vanillyl alcohol = H2O2 + vanillin." [EC:1.1.3.38, RHEA:10036]
synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" RELATED [EC:1.1.3.38]
synonym: "vanillyl alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.38]
xref: EC:1.1.3.38
xref: KEGG_REACTION:R02877
xref: MetaCyc:1.1.3.38-RXN
xref: RHEA:10036
xref: UM-BBD_reactionID:r0651
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0018466
name: obsolete limonene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_reactionID:r0735]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018467
name: formaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: formaldehyde + H2O + NAD+ = formate + 2 H+ + NADH." [RHEA:16425]
synonym: "formaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.46]
synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.1.46
xref: KEGG_REACTION:R00604
xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:16425
xref: UM-BBD_reactionID:r0240
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0018469
name: obsolete myrtenal dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018470
name: obsolete 4-hydroxybutaraldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018471
name: obsolete 4-chlorobenzaldehyde oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0447]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018472
name: obsolete 1-hydroxy-2-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018473
name: obsolete cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018474
name: 2-formylbenzoate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-formylbenzoate + H2O + NAD+ = 2 H+ + NADH + phthalate." [RHEA:27298]
synonym: "2-carboxybenzaldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.1.78
xref: RHEA:27298
xref: UM-BBD_reactionID:r0490
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0018475
name: obsolete trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018477
name: benzaldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [RHEA:21660]
synonym: "benzaldehyde:NADP+ oxidoreductase" RELATED [EC:1.2.1.7]
synonym: "NADP-linked benzaldehyde dehydrogenase" RELATED [EC:1.2.1.7]
xref: EC:1.2.1.7
xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21660
xref: UM-BBD_enzymeID:r0214
xref: UM-BBD_enzymeID:r0222
is_a: GO:0019115 ! benzaldehyde dehydrogenase [NAD(P)+] activity
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity

[Term]
id: GO:0018478
name: malonate-semialdehyde dehydrogenase (acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [EC:1.2.1.18]
synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" RELATED [EC:1.2.1.18]
synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT []
xref: EC:1.2.1.18
xref: MetaCyc:RXN-9958
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018479
name: benzaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28]
synonym: "benzaldehyde (NAD) dehydrogenase activity" RELATED [EC:1.2.1.28]
synonym: "benzaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.28]
xref: EC:1.2.1.28
xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN
xref: RHEA:11840
xref: UM-BBD_reactionID:r0269
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity
is_a: GO:0019115 ! benzaldehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0018480
name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60]
synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.60]
synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.60]
xref: EC:1.2.1.60
xref: MetaCyc:CHMS-DEHYDROGENASE-RXN
xref: RHEA:15681
xref: UM-BBD_reactionID:r0365
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018481
name: 4-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H2O + NAD+ = 2 H+ + maleylacetate + NADH." [EC:1.2.1.61, RHEA:22420]
synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.61]
xref: EC:1.2.1.61
xref: KEGG_REACTION:R05236
xref: MetaCyc:1.2.1.61-RXN
xref: RHEA:22420
xref: UM-BBD_reactionID:r0229
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018482
name: 4-formylbenzenesulfonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-formylbenzenesulfonate + H2O + NAD+ = 4-sulfobenzoate + 2 H+ + NADH." [EC:1.2.1.62, RHEA:18833]
synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.62]
synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT []
synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.1.62
xref: KEGG_REACTION:R05272
xref: MetaCyc:SYDDEHYD-RXN
xref: RHEA:18833
xref: UM-BBD_reactionID:r0292
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018483
name: 6-oxohexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63]
synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.63]
xref: EC:1.2.1.63
xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN
xref: RHEA:13397
xref: UM-BBD_reactionID:r0175
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018484
name: 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64]
synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.64]
synonym: "p-hydroxybenzaldehyde dehydrogenase activity" RELATED [EC:1.2.1.64]
xref: EC:1.2.1.64
xref: MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN
xref: Reactome:R-HSA-9856794 "Unknown dehydrogenase oxidizes 4-HBz"
xref: RHEA:20305
xref: UM-BBD_reactionID:r0273
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0018485
name: salicylaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [RHEA:18537]
synonym: "salicylaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.65]
xref: EC:1.2.1.65
xref: MetaCyc:1.2.1.65-RXN
xref: RHEA:18537
xref: UM-BBD_enzymeID:r0339
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0018486
name: obsolete 2-butanone oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018487
name: obsolete vanillate O-demethylase (anaerobic) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018488
name: aryl-aldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide." [EC:1.2.3.9]
synonym: "aryl-aldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.9]
xref: EC:1.2.3.9
xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN
xref: RHEA:18569
xref: UM-BBD_reactionID:r0145
is_a: GO:0004031 ! aldehyde oxidase activity

[Term]
id: GO:0018489
name: vanillate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD+." [EC:1.14.13.82, RHEA:13021]
comment: Note that this was EC:1.2.3.12.
synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" RELATED [EC:1.14.13.82]
synonym: "vanillate demethylase (aerobic) activity" EXACT []
synonym: "vanillate demethylase activity" EXACT []
synonym: "vanillate:oxygen oxidoreductase (demethylating)" RELATED [EC:1.14.13.82]
xref: EC:1.14.13.82
xref: KEGG_REACTION:R05274
xref: MetaCyc:RXN-10891
xref: RHEA:13021
xref: UM-BBD_reactionID:r0146
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0018490
name: 4-hydroxyphenylpyruvate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2." [RHEA:17197]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13]
xref: EC:1.2.3.13
xref: KEGG_REACTION:R00042
xref: MetaCyc:1.2.3.13-RXN
xref: RHEA:17197
xref: UM-BBD_reactionID:r0299
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0018491
name: 2-oxobutyrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [GOC:curators]
synonym: "2-ketobutyrate synthase activity" EXACT []
synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT []
synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT []
synonym: "alpha-ketobutyrate synthase activity" EXACT []
synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT []
xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN
xref: RHEA:32135
xref: UM-BBD_reactionID:r0358
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018492
name: obsolete carbon-monoxide dehydrogenase (acceptor) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as carbon-monoxide dehydrogenase (ferredoxin) activity ; GO:0043885.
synonym: "carbon monoxide dehydrogenase activity" BROAD []
is_obsolete: true
replaced_by: GO:0043885

[Term]
id: GO:0018493
name: formylmethanofuran dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formylmethanofuran + A + H2O + H+ = AH(2) + CO2 + methanofuran." [EC:1.2.7.12, RHEA:19841]
synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" RELATED [EC:1.2.7.12]
synonym: "formylmethanofuran:acceptor oxidoreductase activity" RELATED [EC:1.2.7.12]
xref: EC:1.2.7.12
xref: KEGG_REACTION:R03015
xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN
xref: RHEA:19841
xref: UM-BBD_reactionID:r0345
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018494
name: carvone reductase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1R,4R)-dihydrocarvone + A = (R)-carvone + AH2, and (1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2." [EC:1.3.99.25]
xref: EC:1.3.99.25
xref: UM-BBD_reactionID:r0732
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018495
name: obsolete 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018496
name: obsolete 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018497
name: obsolete 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "DDMS dehydrogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018498
name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + H+ + NADH. Also converts (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate to (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate." [EC:1.3.1.87]
xref: EC:1.3.1.87
xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN
xref: UM-BBD_enzymeID:r0436
xref: UM-BBD_enzymeID:r1620
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018499
name: obsolete cis-2,3-dihydrodiol DDT dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018500
name: obsolete trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018501
name: obsolete cis-chlorobenzene dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018502
name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553]
xref: MetaCyc:LINC-RXN
xref: RHEA:15741
xref: UM-BBD_reactionID:r0553
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018503
name: obsolete trans-1,2-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018504
name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19]
synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.19]
synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" RELATED [EC:1.3.1.19]
synonym: "cis-benzene glycol dehydrogenase activity" RELATED [EC:1.3.1.19]
xref: EC:1.3.1.19
xref: MetaCyc:1.3.1.19-RXN
xref: RHEA:15457
xref: UM-BBD_enzymeID:r0080
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018505
name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29]
synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.29]
synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT []
synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" RELATED [EC:1.3.1.29]
synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" RELATED [EC:1.3.1.29]
synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.29]
synonym: "naphthalene dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.29]
xref: EC:1.3.1.29
xref: MetaCyc:1.3.1.29-RXN
xref: RHEA:11832
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018506
name: maleylacetate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32]
synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.3.1.32]
synonym: "maleolylacetate reductase activity" RELATED [EC:1.3.1.32]
xref: EC:1.3.1.32
xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN
xref: UM-BBD_enzymeID:r0099
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018507
name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD+ = H+ + NADH + phenanthrene-3,4-diol." [EC:1.3.1.49, RHEA:16253]
synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" RELATED [EC:1.3.1.49]
synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT []
xref: EC:1.3.1.49
xref: KEGG_REACTION:R04151
xref: MetaCyc:1.3.1.49-RXN
xref: RHEA:16253
xref: UM-BBD_reactionID:r0488
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018508
name: obsolete cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "benzoate cis-diol dehydrogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018509
name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56]
synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT []
synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" RELATED [EC:1.3.1.56]
synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.56]
xref: EC:1.3.1.56
xref: MetaCyc:1.3.1.56-RXN
xref: RHEA:17033
xref: UM-BBD_enzymeID:r0389
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018510
name: phloroglucinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrophloroglucinol + NADP+ = H+ + NADPH + phloroglucinol." [EC:1.3.1.57, RHEA:10080]
synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.57]
xref: EC:1.3.1.57
xref: KEGG_REACTION:R05308
xref: MetaCyc:R5-RXN
xref: RHEA:10080
xref: UM-BBD_reactionID:r0007
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018511
name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ = 2,3-dihydroxy-p-cumate + H+ + NADH." [EC:1.3.1.58, RHEA:23772]
synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.58]
xref: EC:1.3.1.58
xref: KEGG_REACTION:R05240
xref: MetaCyc:RXN-665
xref: RHEA:23772
xref: UM-BBD_reactionID:r0396
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018512
name: obsolete 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59]
comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists.
synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT []
synonym: "1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018513
name: dibenzothiophene dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + H+ + NADH." [EC:1.3.1.60, RHEA:24188]
synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.60]
xref: EC:1.3.1.60
xref: KEGG_REACTION:R05310
xref: MetaCyc:1.3.1.60-RXN
xref: RHEA:24188
xref: UM-BBD_reactionID:r0161
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018515
name: pimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H+ + NADH." [EC:1.3.1.62, RHEA:19665]
synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.62]
xref: EC:1.3.1.62
xref: KEGG_REACTION:R05311
xref: MetaCyc:1.3.1.62-RXN
xref: RHEA:19665
xref: UM-BBD_reactionID:r0194
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018516
name: 2,4-dichlorobenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH." [RHEA:23076]
synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" RELATED [EC:1.21.1.2]
xref: EC:1.21.1.2
xref: KEGG_REACTION:R05276
xref: MetaCyc:1.3.1.63-RXN
xref: RHEA:23076
xref: UM-BBD_reactionID:r0138
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0018517
name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + H+ + NADH." [EC:1.3.1.64, RHEA:13837]
synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.64]
xref: EC:1.3.1.64
xref: KEGG_REACTION:R05275
xref: MetaCyc:1.3.1.64-RXN
xref: RHEA:13837
xref: UM-BBD_reactionID:r0142
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018518
name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H+ + NADH." [EC:1.3.1.65, RHEA:24556]
synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED []
synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.65]
xref: EC:1.3.1.65
xref: KEGG_REACTION:R05312
xref: MetaCyc:RXN-643
xref: RHEA:24556
xref: UM-BBD_reactionID:r0053
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018519
name: cis-dihydroethylcatechol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + H+ + NADH." [EC:1.3.1.66, RHEA:18101]
synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.66]
synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT []
xref: EC:1.3.1.66
xref: KEGG_REACTION:R05313
xref: MetaCyc:1.3.1.66-RXN
xref: RHEA:18101
xref: UM-BBD_reactionID:r0309
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018520
name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67]
synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT []
synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.67]
xref: EC:1.3.1.67
xref: MetaCyc:1.3.1.67-RXN
xref: UM-BBD_reactionID:r0179
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018521
name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH." [EC:1.3.1.68, RHEA:15657]
synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.68]
xref: EC:1.3.1.68
xref: KEGG_REACTION:R05314
xref: MetaCyc:1.3.1.68-RXN
xref: RHEA:15657
xref: UM-BBD_reactionID:r0224
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018522
name: benzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H2O + benzoyl-CoA + reduced ferredoxin." [EC:1.3.7.8]
synonym: "benzoyl-CoA reductase (dearomatizing) activity" RELATED [EC:1.3.7.8]
synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity" EXACT [KEGG_REACTION:R02451]
xref: EC:1.3.7.8
xref: KEGG_REACTION:R02451
xref: MetaCyc:1.3.99.15-RXN
xref: RHEA:30199
xref: UM-BBD_reactionID:r0190
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0018523
name: quinoline 2-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17]
synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.17]
xref: EC:1.3.99.17
xref: MetaCyc:1.3.99.17-RXN
xref: RHEA:17749
xref: UM-BBD_reactionID:r0045
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018524
name: obsolete acetophenone carboxylase activity
namespace: molecular_function
alt_id: GO:0018797
def: "OBSOLETE. Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_reactionID:r0033]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018525
name: 4-hydroxybenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin." [RHEA:29603]
synonym: "4-hydroxybenzoyl-coA reductase (dehydroxylating) activity" RELATED []
synonym: "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity" RELATED []
xref: EC:1.1.7.1
xref: KEGG_REACTION:R05316
xref: MetaCyc:OHBENZCOARED-RXN
xref: RHEA:29603
xref: UM-BBD_reactionID:r0158
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0018526
name: obsolete 2-aminobenzoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018527
name: cyclohexylamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide." [PMID:18451, RHEA:18433]
synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.12]
xref: EC:1.4.3.12
xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN
xref: RHEA:18433
xref: UM-BBD_reactionID:r0754
is_a: GO:0008131 ! primary methylamine oxidase activity

[Term]
id: GO:0018528
name: obsolete iminodiacetate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018529
name: nitrilotriacetate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrilotriacetate + FMNH2 + O2 = aminodiacetate + FMN + glyoxylate + H2O." [RHEA:31359]
xref: EC:1.14.14.10
xref: KEGG_REACTION:R09798
xref: MetaCyc:RXN-9508
xref: RHEA:31359
xref: UM-BBD_reactionID:r0587
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018530
name: (R)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2." [EC:1.5.3.6, RHEA:10012]
synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.6]
synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT []
synonym: "D-6-hydroxynicotine oxidase activity" RELATED [EC:1.5.3.6]
xref: EC:1.5.3.6
xref: KEGG_REACTION:R07170
xref: MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN
xref: RHEA:10012
xref: UM-BBD_reactionID:r0477
is_a: GO:0019116 ! hydroxy-nicotine oxidase activity

[Term]
id: GO:0018531
name: (S)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2." [EC:1.5.3.5, RHEA:11880]
synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.5]
synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT []
synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.5]
synonym: "L-6-hydroxynicotine oxidase activity" EXACT []
xref: EC:1.5.3.5
xref: KEGG_REACTION:R03202
xref: MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN
xref: RHEA:11880
xref: UM-BBD_reactionID:r0478
is_a: GO:0019116 ! hydroxy-nicotine oxidase activity

[Term]
id: GO:0018532
name: obsolete 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_reactionID:r0353]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT []
synonym: "coenzyme F420-independent methylene-H4MPT dehydrogenase activity" EXACT []
synonym: "F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT []
synonym: "F420-independent methylene-H4MPT dehydrogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018533
name: peptidyl-cysteine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-cysteine." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006473 ! protein acetylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018534
name: obsolete nitrilotriacetate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0588]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018535
name: nicotine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4]
synonym: "D-nicotine oxidase activity" RELATED [EC:1.5.99.4]
synonym: "nicotine oxidase activity" RELATED [EC:1.5.99.4]
synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" RELATED [EC:1.5.99.4]
synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" RELATED [EC:1.5.99.4]
xref: EC:1.5.99.4
xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN
xref: RHEA:14769
xref: UM-BBD_enzymeID:r0978
xref: UM-BBD_enzymeID:r0979
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018537
name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H+ = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.98.2, RHEA:21144]
synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" RELATED [EC:1.5.98.2]
synonym: "5,10-methylenetetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2]
synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.2]
synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2]
synonym: "methylene-H(4)MPT reductase activity" RELATED [EC:1.5.98.2]
synonym: "methylene-H4MPT reductase activity" RELATED [EC:1.5.98.2]
synonym: "methylenetetrahydromethanopterin reductase activity" EXACT []
synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2]
synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.2]
synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2]
synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.2]
xref: EC:1.5.98.2
xref: KEGG_REACTION:R04464
xref: MetaCyc:METHELENE-THMPT-OXI-RXN
xref: RHEA:21144
xref: UM-BBD_reactionID:r0354
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018538
name: epoxide carboxylase activity
namespace: molecular_function
def: "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888]
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0018541
name: p-benzoquinone reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-benzoquinone + H+ + NADPH = hydroquinone + NADP+." [RHEA:23488]
synonym: "NADPH:p-benzoquinone oxidoreductase activity" RELATED [EC:1.6.5.6]
xref: EC:1.6.5.6
xref: KEGG_REACTION:R05244
xref: MetaCyc:1.6.5.6-RXN
xref: RHEA:23488
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0018542
name: obsolete 2,3-dihydroxy DDT 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_reactionID:r0452]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018543
name: obsolete 4-amino-2-nitroso-6-nitrotoluene reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_reactionID:r0464]
comment: The reason for obsoletion is that this term is out of scope for GO; there is no known physiological substrate.
is_obsolete: true

[Term]
id: GO:0018544
name: obsolete 4-carboxy-4'-sulfoazobenzene reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_reactionID:r0543]
comment: The reason for obsoletion is that this term is out of scope for GO, it is a sub-reaction of GO:0050446.
synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT []
is_obsolete: true
consider: GO:0050446

[Term]
id: GO:0018545
name: obsolete NAD(P)H nitroreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [UM-BBD_enzymeID:e0346]
comment: The reason for obsoletion is that this term is equivalent to GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor.
is_obsolete: true
replaced_by: GO:0046857

[Term]
id: GO:0018546
name: nitrobenzene nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-phenylhydroxylamine + 2 NADP+ = 2 H+ + 2 NADPH + nitrobenzene." [PMID:16517619, RHEA:52884]
xref: EC:1.7.1.16
xref: MetaCyc:RXN-8815
xref: RHEA:52884
xref: UM-BBD_enzymeID:r0303
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0018547
name: obsolete nitroglycerin reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "NG reductase activity" EXACT []
xref: Reactome:R-HSA-9620103 "ALDH2 transforms GTN to NO"
is_obsolete: true

[Term]
id: GO:0018548
name: obsolete pentaerythritol trinitrate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [PMID:29168057, PMID:31119061]
comment: This term was obsoleted because it represents a narrower specificity than any known enzyme, see PMID:29168057.
is_obsolete: true

[Term]
id: GO:0018549
name: methanethiol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide." [EC:1.8.3.4]
synonym: "(MM)-oxidase activity" RELATED [EC:1.8.3.4]
synonym: "methanethiol:oxygen oxidoreductase activity" RELATED [EC:1.8.3.4]
synonym: "methyl mercaptan oxidase activity" RELATED [EC:1.8.3.4]
synonym: "methylmercaptan oxidase activity" RELATED [EC:1.8.3.4]
synonym: "MT-oxidase activity" RELATED [EC:1.8.3.4]
xref: EC:1.8.3.4
xref: MetaCyc:METHANETHIOL-OXIDASE-RXN
xref: RHEA:11812
xref: UM-BBD_reactionID:r0209
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0018550
name: obsolete tetrachloro-p-hydroquinone reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "tetrachlorohydroquinone reductive dehalogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018551
name: dissimilatory sulfite reductase activity
namespace: molecular_function
def: "Catalysis of the reactions: [DsrC protein]-trisulfide + 3 H2O + NAD+ = [DsrC protein]-dithiol + 3 H+ + NADH + sulfite." [RHEA:78943]
synonym: "siroheme sulfite reductase activity" RELATED []
xref: EC:1.8.1.22
xref: MetaCyc:RXN-17803
xref: RHEA:78943
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0018553
name: obsolete 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018554
name: 1,2-dihydroxynaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:r0336]
xref: EC:1.13.11.56
xref: RHEA:27310
xref: UM-BBD_enzymeID:r0336
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0018555
name: obsolete phenanthrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_reactionID:r0455]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018556
name: obsolete 2,2',3-trihydroxybiphenyl dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018557
name: obsolete 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0422]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018558
name: obsolete 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_reactionID:r0049]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018559
name: obsolete 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_reactionID:r0442]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018560
name: obsolete protocatechuate 3,4-dioxygenase type II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_reactionID:r0581]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018561
name: obsolete 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_reactionID:r0457]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018562
name: obsolete 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0415]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018563
name: obsolete 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_reactionID:r0310]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018564
name: carbazole 1,9a-dioxygenase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: 9H-carbazole + H+ + NAD(P)H + O2 = 2'-aminobiphenyl-2,3-diol + NAD(P)+." [EC:1.14.12.22]
synonym: "carbazole 1,9alpha-dioxygenase activity" EXACT []
synonym: "CARDO" EXACT [EC:1.14.12.22]
xref: EC:1.14.12.22
xref: UM-BBD_reactionID:r0456
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018565
name: obsolete dihydroxydibenzothiophene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0162]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018566
name: obsolete 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0324]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018567
name: obsolete styrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_reactionID:r0256]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018568
name: obsolete 3,4-dihydroxyphenanthrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_reactionID:r0501]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018569
name: obsolete hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_reactionID:r0228]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018570
name: p-cumate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [RHEA:42344]
xref: EC:1.14.12.25
xref: MetaCyc:RXN-664
xref: RHEA:42344
xref: UM-BBD_reactionID:r0395
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018571
name: 2,3-dihydroxy-p-cumate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [RHEA:42568]
synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT []
synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT []
xref: MetaCyc:RXN-666
xref: RHEA:42568
xref: UM-BBD_reactionID:r0397
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018572
name: obsolete 3,5-dichlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0276]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018573
name: obsolete 2-aminophenol 1,6-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_reactionID:r0305]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018574
name: obsolete 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018575
name: obsolete chlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0655]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018576
name: catechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [RHEA:23852]
synonym: "1,2-pyrocatechase activity" RELATED [EC:1.13.11.1]
synonym: "catechase activity" RELATED [EC:1.13.11.1]
synonym: "catechol 1,2-oxygenase activity" RELATED [EC:1.13.11.1]
synonym: "catechol-oxygen 1,2-oxidoreductase activity" RELATED [EC:1.13.11.1]
synonym: "catechol:oxygen 1,2-oxidoreductase activity" RELATED [EC:1.13.11.1]
synonym: "CD I" RELATED [EC:1.13.11.1]
synonym: "CD II" RELATED [EC:1.13.11.1]
synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1]
synonym: "pyrocatechol 1,2-dioxygenase activity" RELATED [EC:1.13.11.1]
xref: EC:1.13.11.1
xref: MetaCyc:CATECHOL-12-DIOXYGENASE-RXN
xref: RHEA:23852
xref: UM-BBD_enzymeID:r0601
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018577
name: catechol 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [RHEA:17337]
synonym: "2,3-pyrocatechase activity" RELATED [EC:1.13.11.2]
synonym: "catechol 2,3-oxygenase" RELATED [EC:1.13.11.2]
synonym: "catechol oxygenase" RELATED [EC:1.13.11.2]
synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.2]
synonym: "cato2ase activity" RELATED [EC:1.13.11.2]
synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2]
synonym: "pyrocatechol 2,3-dioxygenase" RELATED [EC:1.13.11.2]
xref: EC:1.13.11.2
xref: MetaCyc:CATECHOL-23-DIOXYGENASE-RXN
xref: RHEA:17337
xref: UM-BBD_enzymeID:r0307
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018578
name: protocatechuate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3]
synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3]
synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.3]
synonym: "protocatechuic 3,4-dioxygenase activity" RELATED [EC:1.13.11.3]
synonym: "protocatechuic 3,4-oxygenase activity" RELATED [EC:1.13.11.3]
synonym: "protocatechuic acid oxidase activity" RELATED [EC:1.13.11.3]
xref: EC:1.13.11.3
xref: MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN
xref: RHEA:10084
xref: UM-BBD_reactionID:r0143
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018579
name: protocatechuate 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8]
synonym: "protocatechuate 4,5-oxygenase activity" RELATED [EC:1.13.11.8]
synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.8]
synonym: "protocatechuic 4,5-dioxygenase activity" RELATED [EC:1.13.11.8]
synonym: "protocatechuic 4,5-oxygenase activity" RELATED [EC:1.13.11.8]
xref: EC:1.13.11.8
xref: MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN
xref: RHEA:24044
xref: UM-BBD_reactionID:r0144
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018580
name: nitronate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28767]
comment: Where non-covalently bound FMN is used as the cofactor, see instead 'nitronate monooxygenase (FMN-linked) activity ; GO:0036434'.
synonym: "2-nitropropane dioxygenase activity" RELATED [EC:1.13.12.16]
synonym: "nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity" EXACT systematic_synonym [EC:1.13.12.16]
xref: EC:1.13.12.16
xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN
xref: RHEA:28767
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0018581
name: hydroxyquinol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H+." [RHEA:19441]
xref: MetaCyc:RXN-17556
xref: RHEA:19441
xref: UM-BBD_reactionID:r0232
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018582
name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT []
synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" RELATED [EC:1.13.11.38]
xref: EC:1.13.11.38
xref: MetaCyc:1.13.11.38-RXN
xref: RHEA:14749
xref: UM-BBD_reactionID:r0486
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018583
name: biphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39]
synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD []
synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39]
synonym: "biphenyl-2,3-diol dioxygenase activity" RELATED [EC:1.13.11.39]
synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.39]
xref: EC:1.13.11.39
xref: MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN
xref: RHEA:14413
xref: UM-BBD_enzymeID:r0390
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018584
name: obsolete 2,4,5-trichlorophenoxyacetic acid oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_reactionID:r0359]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018585
name: obsolete fluorene oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018586
name: obsolete mono-butyltin dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "MBT dioxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018587
name: obsolete limonene 8-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "limonene 8-monooxygenase activity" EXACT []
is_obsolete: true
replaced_by: GO:0019113

[Term]
id: GO:0018588
name: obsolete tri-n-butyltin dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "TBT dioxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018589
name: obsolete di-n-butyltin dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "DBT dioxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018590
name: obsolete methylsilanetriol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018591
name: methyl tertiary butyl ether 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023]
synonym: "MTBE 3-monooxygenase activity" EXACT []
xref: UM-BBD_reactionID:r1023
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018592
name: 4-nitrocatechol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol." [UM-BBD_reactionID:r0231]
xref: EC:1.14.13.166
xref: UM-BBD_reactionID:r0231
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018593
name: obsolete 4-chlorophenoxyacetate monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018594
name: tert-butanol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615]
synonym: "tert-butyl alcohol 2-monooxygenase activity" EXACT []
xref: UM-BBD_reactionID:r0615
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018595
name: obsolete alpha-pinene monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_reactionID:r0716]
comment: This term was obsoleted because it represents the same reaction as alpha-pinene monooxygenase [NADH] activity ; GO:0018634.
is_obsolete: true
consider: GO:0046249

[Term]
id: GO:0018596
name: obsolete dimethylsilanediol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "DMSD hydroxylase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018597
name: ammonia monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + NH4+ + O2 = A + H+ + H2O + hydroxylamine." [PMID:16347810, RHEA:27341]
xref: EC:1.14.99.39
xref: RHEA:27341
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018598
name: obsolete hydroxymethylsilanetriol oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018599
name: obsolete 2-hydroxyisobutyrate 3-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018600
name: obsolete alpha-pinene dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_reactionID:r0709]
comment: This term was obsoleted because there is no evidence that this reaction exists.
is_obsolete: true
consider: GO:0046249

[Term]
id: GO:0018601
name: 4-nitrophenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrophenol + H+ + NADH + O2 = 4-nitrocatechol + H2O + NAD+." [EC:1.14.13.29, RHEA:12568]
synonym: "4-nitrophenol hydroxylase activity" RELATED [EC:1.14.13.29]
synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.29]
synonym: "4-nitrophenol-2-hydroxylase activity" RELATED [EC:1.14.13.29]
xref: EC:1.14.13.29
xref: KEGG_REACTION:R03023
xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN
xref: RHEA:12568
xref: UM-BBD_reactionID:r0230
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018602
name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274]
xref: MetaCyc:RXN-9863
xref: RHEA:48984
xref: UM-BBD_reactionID:r0274
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0018603
name: obsolete nitrobenzene 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol." [UM-BBD_reactionID:r0306]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018604
name: obsolete 4-aminobenzoate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0566]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018606
name: obsolete benzenesulfonate dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_reactionID:r0295]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "benzenesulphonate dioxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018607
name: obsolete 1-indanone monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_reactionID:r0417]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018608
name: obsolete 1-indanone dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_reactionID:r0416]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018609
name: obsolete chlorobenzene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018610
name: dibenzofuran 4,4a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN, RHEA:42460]
xref: MetaCyc:R606-RXN
xref: RHEA:42460
xref: UM-BBD_enzymeID:r0026
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018611
name: obsolete toluate dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018612
name: obsolete dibenzothiophene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_reactionID:r0160]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018613
name: obsolete 9-fluorenone dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_reactionID:r0409]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018614
name: obsolete ethylbenzene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_reactionID:r0247]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018615
name: obsolete 2-indanone monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_reactionID:r0424]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018616
name: trihydroxytoluene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [PMID:1254564, UM-BBD_reactionID:r0093]
xref: MetaCyc:R305-RXN
xref: UM-BBD_reactionID:r0093
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018617
name: obsolete 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_reactionID:r0580]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018618
name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1]
synonym: "AntA" RELATED []
synonym: "AntB" RELATED []
synonym: "AntC" RELATED []
synonym: "anthranilate 1,2-dioxygenase" RELATED []
synonym: "anthranilate dioxygenase activity" EXACT []
synonym: "anthranilate dioxygenase reductase" NARROW []
synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1]
synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" RELATED [EC:1.14.12.1]
synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1]
synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1]
xref: EC:1.14.12.1
xref: MetaCyc:1.14.12.1-RXN
xref: UM-BBD_reactionID:r0577
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018619
name: benzene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.3, RHEA:13813]
synonym: "benzene dioxygenase activity" RELATED [EC:1.14.12.3]
synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3]
synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.3]
xref: EC:1.14.12.3
xref: KEGG_REACTION:R03543
xref: MetaCyc:BENZENE-12-DIOXYGENASE-RXN
xref: RHEA:13813
xref: UM-BBD_reactionID:r0079
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018620
name: phthalate 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+." [EC:1.14.12.7, RHEA:17489]
synonym: "PDO activity" RELATED [EC:1.14.12.7]
synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7]
synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" RELATED [EC:1.14.12.7]
xref: EC:1.14.12.7
xref: KEGG_REACTION:R03630
xref: MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN
xref: RHEA:17489
xref: UM-BBD_reactionID:r0102
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018621
name: 4-sulfobenzoate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite." [EC:1.14.12.8, RHEA:13937]
synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8]
synonym: "4-sulfobenzoate dioxygenase activity" RELATED [EC:1.14.12.8]
synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" RELATED [EC:1.14.12.8]
synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT []
xref: EC:1.14.12.8
xref: KEGG_REACTION:R01636
xref: MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN
xref: RHEA:13937
xref: UM-BBD_reactionID:r0293
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018622
name: 4-chlorophenylacetate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+." [EC:1.14.12.9, RHEA:14689]
synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" RELATED [EC:1.14.12.9]
xref: EC:1.14.12.9
xref: KEGG_REACTION:R03306
xref: MetaCyc:1.14.12.9-RXN
xref: RHEA:14689
xref: UM-BBD_reactionID:r0308
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018623
name: benzoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10]
synonym: "benzoate dioxygenase activity" RELATED [EC:1.14.12.10]
synonym: "benzoate hydroxylase activity" RELATED [EC:1.14.12.10]
synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.10]
synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" RELATED [EC:1.14.12.10]
synonym: "benzoic hydroxylase activity" RELATED [EC:1.14.12.10]
xref: EC:1.14.12.10
xref: MetaCyc:BENZOATE-12-DIOXYGENASE-RXN
xref: RHEA:12633
xref: UM-BBD_enzymeID:r0245
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018624
name: toluene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.11, RHEA:16737]
synonym: "toluene 1,2-dioxygenase activity" RELATED [EC:1.14.12.11]
synonym: "toluene 2,3-dioxygenase activity" RELATED [EC:1.14.12.11]
synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.11]
xref: EC:1.14.12.11
xref: KEGG_REACTION:R03559
xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN
xref: RHEA:16737
xref: UM-BBD_enzymeID:r0253
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018625
name: naphthalene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12]
synonym: "naphthalene dioxygenase activity" RELATED [EC:1.14.12.12]
synonym: "naphthalene oxygenase activity" RELATED [EC:1.14.12.12]
synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.12]
xref: EC:1.14.12.12
xref: MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN
xref: RHEA:19173
xref: UM-BBD_enzymeID:r0334
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018626
name: 2-chlorobenzoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13]
synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" RELATED [EC:1.14.12.13]
synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT []
xref: EC:1.14.12.13
xref: MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN
xref: RHEA:21652
xref: UM-BBD_reactionID:r0632
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018627
name: 2-aminobenzenesulfonate 2,3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0018605
def: "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol." [EC:1.14.12.14, RHEA:23468]
synonym: "2-aminobenzenesulfonate dioxygenase activity" EXACT []
synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" RELATED [EC:1.14.12.14]
synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT []
synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT []
synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" RELATED [EC:1.14.12.14]
xref: EC:1.14.12.14
xref: KEGG_REACTION:R05156
xref: MetaCyc:2ASDOSALCAL-RXN
xref: RHEA:23468
xref: UM-BBD_reactionID:r0218
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018628
name: terephthalate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+." [EC:1.14.12.15, RHEA:10312]
synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" RELATED [EC:1.14.12.15]
synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" RELATED [EC:1.14.12.15]
synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.15]
xref: EC:1.14.12.15
xref: KEGG_REACTION:R05148
xref: MetaCyc:1.14.12.15-RXN
xref: RHEA:10312
xref: UM-BBD_reactionID:r0150
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018629
name: 2-hydroxyquinoline 5,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16]
synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT []
synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" RELATED [EC:1.14.12.16]
synonym: "quinolin-2-ol 5,6-dioxygenase activity" RELATED [EC:1.14.12.16]
synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" RELATED [EC:1.14.12.16]
xref: EC:1.14.12.16
xref: MetaCyc:1.14.12.16-RXN
xref: RHEA:10976
xref: UM-BBD_reactionID:r0052
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018630
name: obsolete 3,5-xylenol methylhydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_reactionID:r0081]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018631
name: phenylacetate 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:53392]
synonym: "phenylacetate hydroxylase activity" EXACT []
xref: EC:1.14.14.54
xref: RHEA:53392
xref: UM-BBD_reactionID:r0036
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018632
name: 4-nitrophenol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [RHEA:34327]
xref: EC:1.14.13.167
xref: MetaCyc:RXN-8739
xref: RHEA:34327
xref: UM-BBD_reactionID:r0226
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018633
name: dimethyl sulfide monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethyl sulfide + H+ + NADH + O2 = formaldehyde + H2O + methanethiol + NAD+." [PMID:21216999, RHEA:31355]
synonym: "dimethyl sulphide monooxygenase activity" EXACT []
xref: EC:1.14.13.131
xref: RHEA:31355
xref: UM-BBD_reactionID:r0208
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018634
name: alpha-pinene monooxygenase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [RHEA:32891]
synonym: "alpha-pinene monooxygenase [NADH] activity" EXACT []
xref: EC:1.14.13.155
xref: RHEA:32891
xref: UM-BBD_reactionID:r0742
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018635
name: obsolete (R)-limonene 1,2-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of limonene 1,2-monooxygenase activity ; GO:0052601.
is_obsolete: true
replaced_by: GO:0052601

[Term]
id: GO:0018636
name: obsolete phenanthrene 9,10-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [PMID:1599252, UM-BBD_reactionID:r0495]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018637
name: 1-hydroxy-2-naphthoate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NAD(P)H + 2 H+ = NAD(P)+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [EC:1.14.13.135, PMID:20727010, PMID:21545490, UM-BBD_reactionID:r0491]
xref: EC:1.14.13.135
xref: UM-BBD_reactionID:r0491
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018638
name: toluene 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + H+ + NADH + O2 = 4-methylphenol + H2O + NAD+." [PMID:15240250, PMID:36593585, RHEA:41380]
xref: EC:1.14.13.236
xref: RHEA:41380
xref: UM-BBD_enzymeID:r0255
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018639
name: obsolete xylene monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018640
name: dibenzothiophene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [RHEA:49076]
xref: MetaCyc:RXN-621
xref: RHEA:49076
xref: UM-BBD_enzymeID:r0037
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018641
name: obsolete 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018642
name: obsolete chlorophenol 4-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018643
name: obsolete carbon disulfide oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_reactionID:r0599]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "carbon disulphide oxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018644
name: toluene 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + H+ + NADH + O2 = 2-hydroxytoluene + H2O + NAD+." [RHEA:20349]
xref: EC:1.14.13.243
xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN
xref: RHEA:20349
xref: UM-BBD_enzymeID:r0260
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018645
name: alkene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69]
synonym: "alkene epoxygenase activity" RELATED [EC:1.14.13.69]
synonym: "alkene,NADH:oxygen oxidoreductase activity" RELATED [EC:1.14.13.69]
xref: EC:1.14.13.69
xref: MetaCyc:1.14.13.69-RXN
xref: RHEA:11792
xref: UM-BBD_enzymeID:r0856
xref: UM-BBD_enzymeID:r0857
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018646
name: obsolete 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_reactionID:r0736]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018647
name: obsolete phenanthrene 1,2-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [PMID:1599252, UM-BBD_enzymeID:e0333]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018648
name: methanesulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." [EC:1.14.13.111]
synonym: "mesylate monooxygenase activity" RELATED [EC:1.14.13.111]
synonym: "methanesulfonate,FMNH2:oxygen oxidoreductase activity" RELATED [EC:1.14.13.111]
synonym: "methanesulfonate,NADH:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.111]
synonym: "methanesulfonic acid monooxygenase activity" RELATED [EC:1.14.13.111]
synonym: "methanesulphonic acid monooxygenase activity" EXACT [GOC:mah]
synonym: "MSA monooxygenase activity" RELATED [EC:1.14.13.111]
synonym: "MSAMO activity" RELATED [EC:1.14.13.111]
xref: EC:1.14.13.111
xref: MetaCyc:RXN-9770
xref: RHEA:26077
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018649
name: obsolete tetrahydrofuran hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_reactionID:r0017]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018650
name: obsolete styrene monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_reactionID:r0225]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018651
name: obsolete toluene-4-sulfonate monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_reactionID:r0296]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "toluene-4-sulphonate monooxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018652
name: toluene-sulfonate methyl-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [RHEA:51024]
synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT []
xref: MetaCyc:TSMOS-RXN
xref: RHEA:51024
xref: UM-BBD_reactionID:r0290
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018653
name: obsolete 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018654
name: obsolete 2-hydroxy-phenylacetate hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [PMID:8919815, UM-BBD_reactionID:r0252]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018655
name: obsolete 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_reactionID:r0430]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018656
name: obsolete phenanthrene 3,4-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [PMID:1599252, UM-BBD_reactionID:r0508]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018657
name: obsolete toluene 3-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this activity exists; this reaction is not present in other biochemical reaction databases.
is_obsolete: true

[Term]
id: GO:0018658
name: salicylate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1]
synonym: "salicylate 1-hydroxylase activity" RELATED [EC:1.14.13.1]
synonym: "salicylate hydroxylase (decarboxylating)" RELATED [EC:1.14.13.1]
synonym: "salicylate hydroxylase activity" EXACT []
synonym: "salicylate monooxygenase activity" RELATED [EC:1.14.13.1]
synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" RELATED [EC:1.14.13.1]
synonym: "salicylic hydroxylase activity" RELATED [EC:1.14.13.1]
xref: EC:1.14.13.1
xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN
xref: RHEA:11004
xref: UM-BBD_enzymeID:r0340
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018659
name: 4-hydroxybenzoate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2]
synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "4-hydroxybenzoate monooxygenase activity" RELATED [EC:1.14.13.2]
synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.2]
synonym: "p-hydroxybenzoate hydrolyase activity" RELATED [EC:1.14.13.2]
synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "p-hydroxybenzoate-3-hydroxylase activity" RELATED [EC:1.14.13.2]
synonym: "p-hydroxybenzoic acid hydrolase activity" RELATED [EC:1.14.13.2]
synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "p-hydroxybenzoic hydroxylase activity" RELATED [EC:1.14.13.2]
synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2]
xref: EC:1.14.13.2
xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN
xref: UM-BBD_reactionID:r0109
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018660
name: obsolete 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [GOC:curators]
comment: RHEA:16681 (RHEA:16681 has been replaced by RHEA:30595); The EC assigned this term does not use NAD but FAD\nGO:0052881 already assigned RHEA:30595 using FADH; \nSince GO:0018660 was assigned to RHEA 16681 with NAD vs FAD; 3 IEA; suggest obsoletion of GO:0018660
synonym: "4 HPA 3-hydroxylase activity" BROAD []
synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" BROAD []
synonym: "4-hydroxyphenylacetate 3-monooxygenase activity" BROAD []
synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD []
synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD []
is_obsolete: true

[Term]
id: GO:0018661
name: orcinol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD+." [EC:1.14.13.6, RHEA:19601]
synonym: "orcinol hydroxylase activity" EXACT []
synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.6]
xref: EC:1.14.13.6
xref: KEGG_REACTION:R02830
xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN
xref: RHEA:19601
xref: UM-BBD_reactionID:r0092
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018662
name: phenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7]
synonym: "phenol hydroxylase activity" RELATED [EC:1.14.13.7]
synonym: "phenol o-hydroxylase activity" RELATED [EC:1.14.13.7]
synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.7]
xref: EC:1.14.13.7
xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN
xref: RHEA:17061
xref: UM-BBD_enzymeID:r0696
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018663
name: 2,6-dihydroxypyridine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxypyridine + H+ + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD+." [EC:1.14.13.10, RHEA:16917]
synonym: "2,6-dihydroxypyridine oxidase activity" EXACT []
synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.10]
xref: EC:1.14.13.10
xref: KEGG_REACTION:R04130
xref: MetaCyc:1.14.13.10-RXN
xref: RHEA:16917
xref: UM-BBD_reactionID:r0479
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018664
name: benzoate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + H+ + NADPH + O2 = 4-hydroxybenzoate + H2O + NADP+." [EC:1.14.14.92, RHEA:18033]
synonym: "4-hydroxybenzoic hydroxylase activity" EXACT []
synonym: "benzoate 4-hydroxylase activity" RELATED [EC:1.14.14.92]
synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.14.92]
synonym: "benzoate-p-hydroxylase activity" RELATED [EC:1.14.14.92]
synonym: "benzoate-para-hydroxylase activity" RELATED [EC:1.14.14.92]
synonym: "benzoic 4-hydroxylase activity" RELATED [EC:1.14.14.92]
synonym: "benzoic acid 4-hydroxylase activity" RELATED [EC:1.14.14.92]
synonym: "p-hydroxybenzoate hydroxylase activity" RELATED [EC:1.14.14.92]
xref: EC:1.14.14.92
xref: KEGG_REACTION:R01295
xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN
xref: RHEA:18033
xref: UM-BBD_reactionID:r0623
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018665
name: 4-hydroxyphenylacetate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18]
synonym: "4-HPA 1-hydroxylase activity" RELATED [EC:1.14.13.18]
synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT []
synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" RELATED [EC:1.14.13.18]
synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" RELATED [EC:1.14.13.18]
synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" RELATED [EC:1.14.13.18]
xref: EC:1.14.13.18
xref: MetaCyc:1.14.13.18-RXN
xref: UM-BBD_reactionID:r0300
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018666
name: 2,4-dichlorophenol 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20]
synonym: "2,4-dichlorophenol hydroxylase activity" EXACT []
synonym: "2,4-dichlorophenol monooxygenase activity" RELATED [EC:1.14.13.20]
synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.20]
xref: EC:1.14.13.20
xref: MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN
xref: RHEA:20920
xref: UM-BBD_enzymeID:r0275
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018667
name: cyclohexanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22]
synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT []
synonym: "cyclohexanone oxygenase activity" RELATED [EC:1.14.13.22]
synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" RELATED [EC:1.14.13.22]
synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" RELATED [EC:1.14.13.22]
xref: EC:1.14.13.22
xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN
xref: RHEA:24068
xref: UM-BBD_reactionID:r0166
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018668
name: 3-hydroxybenzoate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+." [EC:1.14.13.23, RHEA:11480]
synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.13.23]
xref: EC:1.14.13.23
xref: KEGG_REACTION:R01628
xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN
xref: RHEA:11480
xref: UM-BBD_reactionID:r0153
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018669
name: 3-hydroxybenzoate 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD+." [EC:1.14.13.24, RHEA:22692]
synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.24]
synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" RELATED [EC:1.14.13.24]
synonym: "m-hydroxybenzoate 6-hydroxylase activity" RELATED [EC:1.14.13.24]
xref: EC:1.14.13.24
xref: KEGG_REACTION:R02589
xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN
xref: RHEA:22692
xref: UM-BBD_reactionID:r0402
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018670
name: 4-aminobenzoate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27]
synonym: "4-aminobenzoate dehydrogenase activity" RELATED [EC:1.14.13.27]
synonym: "4-aminobenzoate hydroxylase activity" EXACT []
synonym: "4-aminobenzoate monooxygenase activity" RELATED [EC:1.14.13.27]
synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" RELATED [EC:1.14.13.27]
xref: EC:1.14.13.27
xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN
xref: UM-BBD_reactionID:r0597
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018671
name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33]
synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33]
synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT []
synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.33]
synonym: "4-hydroxybenzoate-3-hydroxylase activity" RELATED [EC:1.14.13.33]
xref: EC:1.14.13.33
xref: MetaCyc:1.14.13.33-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018672
name: anthranilate 3-monooxygenase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + 2 H+ + NADPH + O2 = 2,3-dihydroxybenzoate + NADP+ + NH4." [EC:1.14.13.35, RHEA:21236]
synonym: "anthranilate 2,3-dioxygenase (deaminating)" RELATED [EC:1.14.13.35]
synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" RELATED [EC:1.14.13.35]
synonym: "anthranilate hydroxylase (deaminating) activity" EXACT []
synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35]
synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" RELATED [EC:1.14.13.35]
xref: EC:1.14.13.35
xref: KEGG_REACTION:R00980
xref: MetaCyc:1.14.13.35-RXN
xref: RHEA:21236
xref: UM-BBD_reactionID:r0578
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018673
name: anthraniloyl-CoA monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40]
synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" RELATED [EC:1.14.13.40]
synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" RELATED [EC:1.14.13.40]
synonym: "anthraniloyl coenzyme A reductase activity" RELATED [EC:1.14.13.40]
xref: EC:1.14.13.40
xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN
xref: UM-BBD_reactionID:r0568
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018674
name: (S)-limonene 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:15129]
synonym: "(-)-limonene 3-hydroxylase activity" RELATED [EC:1.14.14.99]
synonym: "(-)-limonene 3-monooxygenase activity" EXACT []
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.14.99]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.14.99]
synonym: "limonene 3-hydroxylase activity" EXACT []
xref: EC:1.14.14.99
xref: KEGG_REACTION:R02469
xref: MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN
xref: RHEA:15129
xref: UM-BBD_reactionID:r0739
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018675
name: (S)-limonene 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:17945]
synonym: "(-)-limonene 6-hydroxylase activity" RELATED [EC:1.14.14.51]
synonym: "(-)-limonene 6-monooxygenase activity" EXACT []
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" RELATED [EC:1.14.14.51]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.14.51]
synonym: "limonene 6-hydroxylase activity" EXACT []
xref: EC:1.14.14.51
xref: MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN
xref: RHEA:17945
xref: UM-BBD_reactionID:r0713
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018676
name: (S)-limonene 7-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:23432]
synonym: "(-)-limonene 7-monooxygenase activity" EXACT []
xref: EC:1.14.14.52
xref: KEGG_REACTION:R02470
xref: MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN
xref: RHEA:23432
xref: UM-BBD_reactionID:r0728
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018677
name: pentachlorophenol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50]
synonym: "PCB 4-monooxygenase activity" RELATED [EC:1.14.13.50]
synonym: "PCB4MO activity" RELATED [EC:1.14.13.50]
synonym: "PCP hydroxylase activity" RELATED [EC:1.14.13.50]
synonym: "PcpB" RELATED [EC:1.14.13.50]
synonym: "pentachlorophenol 4-monooxygenase activity" EXACT []
synonym: "pentachlorophenol dechlorinase activity" RELATED [EC:1.14.13.50]
synonym: "pentachlorophenol dehalogenase activity" RELATED [EC:1.14.13.50]
synonym: "pentachlorophenol hydroxylase activity" EXACT []
synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" RELATED [EC:1.14.13.50]
xref: EC:1.14.13.50
xref: MetaCyc:PCP4MONO-RXN
xref: RHEA:18685
xref: UM-BBD_enzymeID:r0313
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018678
name: 4-hydroxybenzoate 1-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64]
synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT []
synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" RELATED [EC:1.14.13.64]
xref: EC:1.14.13.64
xref: MetaCyc:1.14.13.64-RXN
xref: UM-BBD_reactionID:r0752
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018679
name: dibenzothiophene sulfone monooxygenase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + H+ + H2O + NAD+." [RHEA:12312]
synonym: "dibenzothiophene-5,5-dioxide monooxygenase activity" NARROW []
xref: EC:1.14.14.22
xref: MetaCyc:RXN-20709
xref: RHEA:12312
xref: UM-BBD_reactionID:r0235
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018680
name: obsolete deethylatrazine monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_reactionID:r0128]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018681
name: obsolete deisopropylatrazine monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine." [KEGG_REACTION:R05567]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018682
name: obsolete atrazine N-dealkylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [UM-BBD_reactionID:r0127]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "atrazine monooxygenase activity" RELATED [UM-BBD_enzymeID:e0090]
is_obsolete: true

[Term]
id: GO:0018683
name: camphor 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1]
synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.15.1]
synonym: "2-bornanone 5-exo-hydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "bornanone 5-exo-hydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "camphor 5-exo-hydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT []
synonym: "camphor 5-exohydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "camphor hydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "camphor methylene hydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "cytochrome p450-cam activity" RELATED [EC:1.14.15.1]
synonym: "d-camphor monooxygenase activity" RELATED [EC:1.14.15.1]
synonym: "D-camphor-exo-hydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "methylene hydroxylase activity" RELATED [EC:1.14.15.1]
synonym: "methylene monooxygenase activity" RELATED [EC:1.14.15.1]
xref: EC:1.14.15.1
xref: MetaCyc:R541-RXN
xref: RHEA:13525
xref: UM-BBD_enzymeID:r0426
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018684
name: 2,5-diketocamphane 1,2-monooxygenase
namespace: molecular_function
def: "Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O." [PMID:3944058, PMID:8515237, RHEA:34415]
synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" RELATED []
synonym: "2,5-diketocamphane lactonizing enzyme activity" RELATED [EC:1.14.14.108]
synonym: "camphor 1,2-monooxygenase activity" EXACT []
synonym: "camphor ketolactonase I activity" RELATED [EC:1.14.14.108]
xref: EC:1.14.14.108
xref: MetaCyc:R543-RXN
xref: RHEA:34415
xref: UM-BBD_enzymeID:r0428
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018685
name: alkane 1-monooxygenase activity
namespace: molecular_function
alt_id: GO:0008393
def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [RHEA:19341]
synonym: "1-hydroxylase activity" RELATED [EC:1.14.15.3]
synonym: "alkane 1-hydroxylase activity" EXACT []
synonym: "alkane hydroxylase activity" RELATED [EC:1.14.15.3]
synonym: "alkane monooxygenase activity" RELATED [EC:1.14.15.3]
synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" RELATED [EC:1.14.15.3]
xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN
xref: RHEA:19341
xref: UM-BBD_enzymeID:r0021
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018686
name: obsolete 6-hydroxy pseudo-oxynicotine monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018687
name: biphenyl 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+." [EC:1.14.12.18]
synonym: "biphenyl dioxygenase activity" RELATED [EC:1.14.12.18]
synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" RELATED [EC:1.14.12.18]
xref: EC:1.14.12.18
xref: MetaCyc:1.14.12.18-RXN
xref: RHEA:18165
xref: UM-BBD_enzymeID:r0388
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018688
name: obsolete DDT 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018689
name: obsolete naphthalene disulfonate 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018690
name: 4-methoxybenzoate monooxygenase (O-demethylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O." [EC:1.14.99.15, RHEA:18613]
synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" RELATED [EC:1.14.99.15]
synonym: "4-methoxybenzoate monooxygenase activity" EXACT []
synonym: "4-methoxybenzoate O-demethylase activity" RELATED [EC:1.14.99.15]
synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" RELATED [EC:1.14.99.15]
synonym: "p-anisic O-demethylase activity" RELATED [EC:1.14.99.15]
synonym: "piperonylate-4-O-demethylase activity" RELATED [EC:1.14.99.15]
xref: EC:1.14.99.15
xref: KEGG_REACTION:R01306
xref: MetaCyc:1.14.99.15-RXN
xref: RHEA:18613
xref: UM-BBD_reactionID:r0154
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018693
name: ethylbenzene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + ethylbenzene + H2O = (S)-1-phenylethanol + AH(2)." [EC:1.17.99.2, RHEA:17897]
synonym: "ethylbenzene dehydrogenase activity" RELATED [EC:1.17.99.2]
synonym: "ethylbenzene:(acceptor) oxidoreductase activity" RELATED [EC:1.17.99.2]
xref: EC:1.17.99.2
xref: KEGG_REACTION:R05745
xref: MetaCyc:RXN-1301
xref: RHEA:17897
xref: UM-BBD_reactionID:r0234
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018694
name: p-cymene methyl hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [RHEA:51604]
xref: EC:1.14.15.25
xref: MetaCyc:RXN-661
xref: RHEA:51604
xref: UM-BBD_reactionID:r0392
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018695
name: 4-cresol dehydrogenase (hydroxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.9.1]
synonym: "4-cresol dehydrogenase activity" EXACT []
synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" RELATED [EC:1.17.9.1]
synonym: "p-cresol methylhydroxylase activity" RELATED [EC:1.17.9.1]
synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" RELATED [EC:1.17.9.1]
xref: EC:1.17.9.1
xref: MetaCyc:1.17.99.1-RXN
xref: RHEA:15141
xref: UM-BBD_reactionID:r0272
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018697
name: obsolete carbonyl sulfide nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of nitrogenase activity ; GO:0016163.
synonym: "carbonyl sulphide nitrogenase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016163

[Term]
id: GO:0018698
name: chloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + chloroethene = A + chloride + ethene + H+." [PMID:15294827, PMID:9171062, RHEA:68004]
synonym: "vinyl chloride reductive dehalogenase activity" EXACT []
xref: MetaCyc:VCREDCHLOR-RXN
xref: RHEA:68004
xref: UM-BBD_reactionID:r0352
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0018699
name: obsolete 1,1,1-trichloroethane reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018700
name: obsolete 2-chloro-N-isopropylacetanilide reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_reactionID:r0719]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018701
name: obsolete 2,5-dichlorohydroquinone reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018702
name: obsolete 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0440]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT []
synonym: "DDE dehalogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018703
name: obsolete 2,4-dichlorophenoxyacetate dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018704
name: obsolete 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [GOC:curators]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018705
name: obsolete 1,2-dichloroethene reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018706
name: pyrogallol hydroxytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [RHEA:21000]
synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" RELATED [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" RELATED [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" RELATED [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" RELATED [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" RELATED [EC:1.97.1.2]
synonym: "pyrogallol hydroxyltransferase activity" EXACT []
synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2]
xref: EC:1.97.1.2
xref: MetaCyc:1.97.1.2-RXN
xref: RHEA:21000
xref: UM-BBD_reactionID:r0006
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018707
name: obsolete 1-phenanthrol methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018708
name: thiol S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9]
synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" RELATED [EC:2.1.1.9]
synonym: "thiol methyltransferase activity" RELATED [EC:2.1.1.9]
synonym: "TMT" RELATED [EC:2.1.1.9]
xref: EC:2.1.1.9
xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-175976 "TMT transfers CH3 from AdoMet to BME"
xref: RHEA:18277
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018710
name: acetone carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetone + ATP + CO2 + 2 H2O = acetoacetate + AMP + 4 H+ + 2 phosphate." [EC:6.4.1.6, RHEA:18385]
synonym: "acetone:carbon-dioxide ligase (AMP-forming)" RELATED [EC:6.4.1.6]
xref: EC:6.4.1.6
xref: KEGG_REACTION:R05735
xref: MetaCyc:6.4.1.6-RXN
xref: RHEA:18385
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0018711
name: benzoyl acetate-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_reactionID:r0243]
xref: MetaCyc:RXN-2006
xref: UM-BBD_reactionID:r0243
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0018712
name: 3-hydroxybutyryl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0010]
xref: MetaCyc:R7-RXN
xref: UM-BBD_reactionID:r0010
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0018713
name: 3-ketopimelyl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0197]
xref: MetaCyc:RXN-8032
xref: UM-BBD_reactionID:r0197
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0018715
name: obsolete 9-phenanthrol UDP-glucuronosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018716
name: obsolete 1-phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018717
name: obsolete 9-phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018718
name: obsolete 1,2-dihydroxy-phenanthrene glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018719
name: 6-aminohexanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_reactionID:r0449]
xref: MetaCyc:R562-RXN
xref: UM-BBD_reactionID:r0449
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0018720
name: phenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + X-phosphate = XH + phenylphosphate." [PMID:16980461, UM-BBD_reactionID:r0155]
xref: MetaCyc:PHENOLPHOS-RXN
xref: UM-BBD_reactionID:r0155
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0018721
name: obsolete trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018722
name: obsolete 1-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "1-phenanthrol sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018723
name: obsolete 3-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "3-phenanthrol sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018724
name: obsolete 4-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "4-phenanthrol sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018725
name: obsolete trans-3,4-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018726
name: obsolete 9-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "9-phenanthrol sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018727
name: obsolete 2-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "2-phenanthrol sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018729
name: propionate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1]
synonym: "acetyl-CoA:propanoate CoA-transferase activity" RELATED [EC:2.8.3.1]
synonym: "propionate coenzyme A-transferase activity" RELATED [EC:2.8.3.1]
synonym: "propionate-CoA:lactoyl-CoA transferase activity" RELATED [EC:2.8.3.1]
synonym: "propionyl CoA:acetate CoA transferase activity" RELATED [EC:2.8.3.1]
synonym: "propionyl-CoA transferase activity" RELATED [EC:2.8.3.1]
xref: EC:2.8.3.1
xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN
xref: RHEA:23520
xref: UM-BBD_reactionID:r0087
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0018730
name: glutaconate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12]
synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" RELATED [EC:2.8.3.12]
xref: EC:2.8.3.12
xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN
xref: RHEA:23208
xref: UM-BBD_reactionID:r0085
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0018731
name: obsolete 1-oxa-2-oxocycloheptane lactonase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018732
name: obsolete sulfolactone hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as 4-sulfomuconolactone hydrolase activity ; GO:0102998.
synonym: "sulpholactone hydrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0102998

[Term]
id: GO:0018733
name: obsolete 3,4-dihydrocoumarin hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as dihydrocoumarin hydrolase activity ; GO:0047856.
is_obsolete: true
replaced_by: GO:0047856

[Term]
id: GO:0018734
name: obsolete butyrolactone hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018736
name: obsolete 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018737
name: obsolete 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018738
name: S-formylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+." [EC:3.1.2.12, RHEA:14961]
subset: goslim_chembl
xref: EC:3.1.2.12
xref: KEGG_REACTION:R00527
xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN
xref: Reactome:R-HSA-5693724 "ESD dimer hydrolyses S-FGSH to GSH"
xref: RHEA:14961
xref: UM-BBD_reactionID:r0241
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0018739
name: 4-hydroxybenzoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H+." [EC:3.1.2.23, RHEA:11948]
synonym: "4-hydroxybenzoyl-CoA hydrolase activity" RELATED [EC:3.1.2.23]
synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT []
xref: EC:3.1.2.23
xref: KEGG_REACTION:R01301
xref: MetaCyc:3.1.2.23-RXN
xref: RHEA:11948
xref: UM-BBD_reactionID:r0141
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0018740
name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + sulfite." [EC:3.13.1.3, RHEA:12945]
synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT []
synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" RELATED [EC:3.13.1.3]
synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" RELATED [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" RELATED [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" RELATED [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" RELATED [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" RELATED [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT []
synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3]
synonym: "DszB" RELATED [EC:3.13.1.3]
synonym: "gene dszB-encoded hydrolase activity" RELATED [EC:3.13.1.3]
synonym: "HBPSi desulfinase activity" RELATED [EC:3.13.1.3]
synonym: "HPBS desulfinase activity" RELATED [EC:3.13.1.3]
xref: EC:3.13.1.3
xref: KEGG_REACTION:R07311
xref: MetaCyc:RXN-624
xref: RHEA:12945
xref: UM-BBD_enzymeID:r0236
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0018741
name: linear primary-alkylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O = a primary alcohol + H+ + sulfate." [RHEA:67908]
synonym: "alkyl sulfatase activity" BROAD []
xref: EC:3.1.6.21
xref: RHEA:67908
xref: UM-BBD_reactionID:r0602
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0018742
name: obsolete epoxide hydrolase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018743
name: obsolete phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018744
name: limonene-1,2-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8]
synonym: "limonene oxide hydrolase activity" RELATED [EC:3.3.2.8]
xref: EC:3.3.2.8
xref: MetaCyc:3.3.2.8-RXN
xref: RHEA:10700
xref: UM-BBD_reactionID:r0734
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0018745
name: obsolete epoxide hydrolase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018746
name: obsolete phenanthrene-3,4-epoxide hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018747
name: obsolete phenanthrene-1,2-epoxide hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018748
name: obsolete iprodione amidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018749
name: obsolete (3,5-dichlorophenylurea)acetate amidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018750
name: biuret amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84]
xref: EC:3.5.1.84
xref: RHEA:17525
xref: UM-BBD_reactionID:r0846
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0018751
name: obsolete 3,5-dichlorophenylcarboximide hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018752
name: epsilon-caprolactam lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_reactionID:r0448]
xref: MetaCyc:R561-RXN
xref: UM-BBD_reactionID:r0448
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018753
name: cyanuric acid amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanurate + H2O = 1-carboxybiuret + H+." [EC:3.5.2.15]
xref: EC:3.5.2.15
xref: MetaCyc:RXN-20062
xref: RHEA:70363
xref: UM-BBD_reactionID:r0116
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018754
name: ammelide aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731]
xref: MetaCyc:RXN-8017
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018755
name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414]
xref: UM-BBD_reactionID:r1414
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018756
name: ammeline aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731]
xref: MetaCyc:RXN-8016
xref: RHEA:26201
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018757
name: deisopropylhydroxyatrazine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_reactionID:r0121]
xref: KEGG_REACTION:R05574
xref: UM-BBD_reactionID:r0121
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018758
name: obsolete 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018759
name: methenyltetrahydromethanopterin cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H+." [EC:3.5.4.27, RHEA:19053]
synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" RELATED [EC:3.5.4.27]
synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" RELATED [EC:3.5.4.27]
synonym: "methenyl-H(4)MPT cyclohydrolase activity" RELATED [EC:3.5.4.27]
synonym: "methenyl-H4MPT cyclohydrolase activity" RELATED [EC:3.5.4.27]
synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" RELATED [EC:3.5.4.27]
xref: EC:3.5.4.27
xref: KEGG_REACTION:R03464
xref: MetaCyc:3.5.4.27-RXN
xref: RHEA:19053
xref: UM-BBD_reactionID:r0347
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0018760
name: thiocyanate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2 H+ + thiocyanate = carbonyl sulfide + NH4." [EC:3.5.5.8, RHEA:21464]
synonym: "thiocyanate aminohydrolase activity" RELATED [EC:3.5.5.8]
xref: EC:3.5.5.8
xref: KEGG_REACTION:R05780
xref: MetaCyc:RXN-1761
xref: RHEA:21464
xref: UM-BBD_reactionID:r0598
is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

[Term]
id: GO:0018761
name: bromoxynil nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4. Involved in the bacterial degradation of the herbicide bromoxynil." [RHEA:22100]
synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT []
synonym: "bromoxynil-specific nitrilase activity" EXACT []
xref: EC:3.5.5.6
xref: KEGG_REACTION:R04349
xref: MetaCyc:3.5.5.6-RXN
xref: RHEA:22100
xref: UM-BBD_enzymeID:r0548
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0018762
name: aliphatic nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7]
synonym: "aliphatic nitrile aminohydrolase activity" RELATED [EC:3.5.5.7]
xref: EC:3.5.5.7
xref: MetaCyc:3.5.5.7-RXN
xref: RHEA:46188
xref: UM-BBD_reactionID:r0622
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0018763
name: hydroxydechloroatrazine ethylaminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.4.43]
synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" RELATED [EC:3.5.4.43]
synonym: "AtzB" RELATED []
synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT []
synonym: "hydroxyatrazine hydrolase activity" RELATED [EC:3.5.4.43]
xref: EC:3.5.4.43
xref: MetaCyc:R122-RXN
xref: RHEA:23092
xref: UM-BBD_enzymeID:r0114
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0018764
name: N-isopropylammelide isopropylaminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.4.42]
synonym: "AtzC" RELATED []
xref: EC:3.5.4.42
xref: MetaCyc:R123-RXN
xref: RHEA:23608
xref: UM-BBD_enzymeID:r0115
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0018765
name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H+." [RHEA:59220]
xref: EC:3.7.1.25
xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN
xref: RHEA:59220
xref: UM-BBD_reactionID:r0263
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018766
name: dihydrophloroglucinol hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_reactionID:r0008]
xref: KEGG_REACTION:R07831
xref: MetaCyc:R6-RXN
xref: UM-BBD_reactionID:r0008
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018767
name: obsolete 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018768
name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H+." [RHEA:27870]
xref: EC:3.7.1.13
xref: MetaCyc:RXN-11543
xref: RHEA:27870
xref: UM-BBD_reactionID:r0458
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018769
name: obsolete 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018770
name: obsolete 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018771
name: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity
namespace: molecular_function
alt_id: GO:0008680
def: "Catalysis of the reaction: (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H+ + succinate." [RHEA:34187]
synonym: "(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14]
synonym: "2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r0438]
xref: MetaCyc:MHPCHYDROL-RXN
xref: RHEA:34187
xref: UM-BBD_reactionID:r0438
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018772
name: trioxoheptanoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094]
xref: MetaCyc:R306-RXN
xref: UM-BBD_reactionID:r0094
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018773
name: acetylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate." [RHEA:16097]
synonym: "2,4-dioxopentanoate acetylhydrolase activity" RELATED [EC:3.7.1.6]
xref: EC:3.7.1.6
xref: KEGG_REACTION:R00324
xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN
xref: RHEA:16097
xref: UM-BBD_reactionID:r0095
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018774
name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H+." [RHEA:17161]
synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" RELATED [EC:3.7.1.8]
synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT []
synonym: "HOHPDA hydrolase activity" RELATED [EC:3.7.1.8]
xref: MetaCyc:3.7.1.8-RXN
xref: RHEA:17161
xref: UM-BBD_enzymeID:r0391
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018775
name: 2-hydroxymuconate-semialdehyde hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H+." [RHEA:14549]
synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" RELATED [EC:3.7.1.9]
synonym: "2-hydroxymuconic semialdehyde hydrolase activity" RELATED [EC:3.7.1.9]
synonym: "HMSH" RELATED [EC:3.7.1.9]
synonym: "HOD hydrolase activity" RELATED [EC:3.7.1.9]
xref: EC:3.7.1.9
xref: MetaCyc:3.7.1.9-RXN
xref: RHEA:14549
xref: UM-BBD_enzymeID:r1671
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018776
name: obsolete trans-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018777
name: obsolete 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214]
comment: This term was obsoleted because it represents a specific substrate of \nhaloalkane dehalogenase activity ; GO:0018786.
is_obsolete: true
replaced_by: GO:0018786

[Term]
id: GO:0018778
name: obsolete DL-2 haloacid dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [PMID:7068529]
comment: This term was obsoleted because it corresponds to (R)-2-haloacid dehalogenase activity ; GO:0033975 and (S)-2-haloacid dehalogenase ; GO:0018784.
is_obsolete: true
consider: GO:0018784
consider: GO:0033975

[Term]
id: GO:0018779
name: obsolete 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018780
name: obsolete dichloroacetate halidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018781
name: obsolete S-triazine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018782
name: obsolete cis-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018783
name: obsolete deisopropyldeethylatrazine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this reaction exists.
is_obsolete: true

[Term]
id: GO:0018784
name: (S)-2-haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2]
synonym: "(S)-2-haloacid halidohydrolase activity" RELATED [EC:3.8.1.2]
synonym: "2-haloacid dehalogenase activity" EXACT []
synonym: "2-haloacid halidohydrolase activity" RELATED [EC:3.8.1.2]
synonym: "2-haloalkanoic acid dehalogenase activity" RELATED [EC:3.8.1.2]
synonym: "2-haloalkanoid acid halidohydrolase activity" RELATED [EC:3.8.1.2]
synonym: "2-halocarboxylic acid dehalogenase II activity" RELATED [EC:3.8.1.2]
synonym: "DL-2-haloacid dehalogenase activity" RELATED [EC:3.8.1.2]
synonym: "halocarboxylic acid halidohydrolase activity" RELATED [EC:3.8.1.2]
synonym: "L-2-haloacid dehalogenase activity" RELATED [EC:3.8.1.2]
synonym: "L-DEX activity" RELATED [EC:3.8.1.2]
xref: EC:3.8.1.2
xref: RHEA:11192
xref: UM-BBD_reactionID:r0090
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018785
name: haloacetate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3]
synonym: "haloacetate halidohydrolase activity" RELATED [EC:3.8.1.3]
synonym: "monohaloacetate dehalogenase activity" RELATED [EC:3.8.1.3]
xref: EC:3.8.1.3
xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN
xref: RHEA:11044
xref: UM-BBD_enzymeID:r0004
xref: UM-BBD_enzymeID:r1028
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018786
name: haloalkane dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [PMID:3624201, RHEA:19081]
synonym: "1-chlorohexane halidohydrolase activity" RELATED [EC:3.8.1.5]
synonym: "1-haloalkane dehalogenase activity" RELATED [EC:3.8.1.5]
synonym: "1-haloalkane halidohydrolase activity" RELATED [EC:3.8.1.5]
xref: EC:3.8.1.5
xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN
xref: RHEA:19081
xref: UM-BBD_enzymeID:r0001
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018787
name: 4-chlorobenzoyl-CoA dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H+." [RHEA:14853]
synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" RELATED [EC:3.8.1.7]
xref: EC:3.8.1.7
xref: MetaCyc:3.8.1.7-RXN
xref: RHEA:14853
xref: UM-BBD_enzymeID:r0140
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018788
name: atrazine chlorohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: atrazine + H2O = chloride + H+ + hydroxyatrazine." [RHEA:11312]
synonym: "AtzA" RELATED [EC:3.8.1.8]
xref: EC:3.8.1.8
xref: KEGG_REACTION:R05558
xref: MetaCyc:3.8.1.8-RXN
xref: RHEA:11312
xref: UM-BBD_reactionID:r0113
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018789
name: cyclamate sulfohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + sulfate." [EC:3.10.1.2, RHEA:18481]
synonym: "cyclamate sulfamatase activity" EXACT []
synonym: "cyclamate sulfamidase activity" RELATED [EC:3.10.1.2]
synonym: "cyclamate sulphohydrolase activity" EXACT []
synonym: "cyclohexylsulfamate sulfamidase activity" RELATED [EC:3.10.1.2]
synonym: "cyclohexylsulfamate sulfohydrolase activity" RELATED [EC:3.10.1.2]
xref: EC:3.10.1.2
xref: KEGG_REACTION:R02564
xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN
xref: RHEA:18481
xref: UM-BBD_reactionID:r0755
is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds

[Term]
id: GO:0018791
name: obsolete 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018792
name: obsolete bis(4-chlorophenyl)acetate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
synonym: "DDA decarboxylase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018793
name: obsolete 3,5-dibromo-4-hydroxybenzoate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018794
name: obsolete 2-hydroxyisobutyrate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018795
name: obsolete 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018796
name: 4,5-dihydroxyphthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55]
synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" RELATED [EC:4.1.1.55]
synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" RELATED [EC:4.1.1.55]
xref: EC:4.1.1.55
xref: MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
xref: RHEA:24184
xref: UM-BBD_enzymeID:r0149
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018798
name: gallate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: gallate + H+ = CO2 + pyrogallol." [EC:4.1.1.59, RHEA:12749]
synonym: "gallate carboxy-lyase (pyrogallol-forming)" RELATED [EC:4.1.1.59]
synonym: "gallate carboxy-lyase activity" RELATED [EC:4.1.1.59]
synonym: "gallic acid decarboxylase activity" EXACT []
xref: EC:4.1.1.59
xref: KEGG_REACTION:R03247
xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN
xref: RHEA:12749
xref: UM-BBD_reactionID:r0005
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018799
name: 4-hydroxybenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + H+ = CO2 + phenol." [EC:4.1.1.61, RHEA:10876]
synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" RELATED [EC:4.1.1.61]
synonym: "4-hydroxybenzoate carboxy-lyase activity" RELATED [EC:4.1.1.61]
synonym: "p-hydroxybenzoate decarboxylase activity" RELATED [EC:4.1.1.61]
xref: EC:4.1.1.61
xref: KEGG_REACTION:R01238
xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN
xref: RHEA:10876
xref: UM-BBD_reactionID:r0159
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018800
name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68]
synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" RELATED [EC:4.1.1.68]
synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT []
synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" RELATED [EC:4.1.1.68]
synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" RELATED [EC:4.1.1.68]
synonym: "HpaG-2" RELATED []
synonym: "HpaG2" RELATED []
synonym: "OPET decarboxylase activity" EXACT []
xref: EC:4.1.1.68
xref: MetaCyc:4.1.1.68-RXN
xref: RHEA:14397
xref: UM-BBD_reactionID:r0367
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018801
name: glutaconyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-glutaconyl-CoA + H+ = but-2-enoyl-CoA + CO2." [PMID:11248185, RHEA:23972]
synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT []
synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" RELATED [EC:7.2.4.5]
synonym: "glutaconyl coenzyme A decarboxylase activity" RELATED [EC:7.2.4.5]
synonym: "pent-2-enoyl-CoA carboxy-lyase activity" RELATED [EC:7.2.4.5]
xref: EC:7.2.4.5
xref: KEGG_REACTION:R03028
xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN
xref: RHEA:23972
xref: UM-BBD_reactionID:r0199
is_a: GO:0015451 ! decarboxylation-driven active transmembrane transporter activity
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018802
name: obsolete 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [PMID:8529896]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018803
name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34]
synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34]
synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.34]
synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34]
synonym: "2'-carboxybenzalpyruvate aldolase activity" RELATED [EC:4.1.2.34]
synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT []
xref: EC:4.1.2.34
xref: MetaCyc:4.1.2.34-RXN
xref: RHEA:16453
xref: UM-BBD_reactionID:r0487
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018805
name: benzylsuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate." [EC:4.1.99.11, RHEA:10416]
synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" RELATED [EC:4.1.99.11]
synonym: "benzylsuccinate fumarate-lyase activity" RELATED [EC:4.1.99.11]
xref: EC:4.1.99.11
xref: KEGG_REACTION:R05598
xref: MetaCyc:RXN-863
xref: RHEA:10416
xref: UM-BBD_enzymeID:r0328
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0018807
name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0204]
xref: EC:3.7.1.21
xref: RHEA:39651
xref: UM-BBD_reactionID:r0204
is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds

[Term]
id: GO:0018808
name: obsolete trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018809
name: obsolete E-phenylitaconyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018810
name: obsolete trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018811
name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191]
xref: MetaCyc:R266-RXN
xref: UM-BBD_reactionID:r0191
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018812
name: 3-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O." [RHEA:33767]
xref: EC:4.2.1.74
xref: Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA"
xref: Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA"
xref: Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA"
xref: Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA"
xref: Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA"
xref: Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA"
xref: Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA"
xref: RHEA:33767
is_a: GO:0004300 ! enoyl-CoA hydratase activity

[Term]
id: GO:0018813
name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:r0338]
xref: EC:4.1.2.45
xref: RHEA:27389
xref: UM-BBD_enzymeID:r0338
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018814
name: phenylacetaldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (trans)-phenylacetaldoxime = H2O + phenylacetonitrile." [PMID:25015725, RHEA:20069]
synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.8.1.4]
synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.8.1.4]
synonym: "PAOx dehydratase activity" RELATED [EC:4.8.1.4]
xref: EC:4.8.1.4
xref: KEGG_REACTION:R07638
xref: MetaCyc:4.99.1.7-RXN
xref: RHEA:20069
xref: UM-BBD_reactionID:r0697
is_a: GO:0141122 ! nitrogen-oxygen hydrolyase activity

[Term]
id: GO:0018815
name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_reactionID:r0051]
xref: MetaCyc:RXN-645
xref: UM-BBD_reactionID:r0051
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018816
name: obsolete 2-hydroxyisobutyrate dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018817
name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_reactionID:r0369]
synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT []
synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT []
synonym: "HpaH" RELATED []
xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN
xref: RHEA:42072
xref: UM-BBD_reactionID:r0369
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018818
name: acetylene hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetaldehyde = acetylene + H2O." [EC:4.2.1.112, RHEA:17885]
synonym: "acetaldehyde hydro-lyase activity" RELATED [EC:4.2.1.112]
synonym: "AH" RELATED [EC:4.2.1.112]
synonym: "AHy" RELATED [EC:4.2.1.112]
xref: EC:4.2.1.112
xref: KEGG_REACTION:R05380
xref: MetaCyc:R141-RXN
xref: RHEA:17885
xref: UM-BBD_reactionID:r0591
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018819
name: lactoyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactoyl-CoA = acryloyl-CoA + H2O." [RHEA:34691]
synonym: "acrylyl coenzyme A hydratase activity" RELATED [EC:4.2.1.54]
synonym: "lactoyl coenzyme A dehydratase activity" RELATED [EC:4.2.1.54]
synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" RELATED [EC:4.2.1.54]
synonym: "lactoyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.54]
synonym: "lactyl CoA dehydratase activity" RELATED [EC:4.2.1.54]
synonym: "lactyl-coenzyme A dehydrase activity" RELATED [EC:4.2.1.54]
xref: EC:4.2.1.54
xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN
xref: RHEA:34691
xref: UM-BBD_reactionID:r0086
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018820
name: cyanamide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: urea = cyanamide + H2O." [EC:4.2.1.69, RHEA:23056]
synonym: "urea hydro-lyase (cyanamide-forming)" RELATED [EC:4.2.1.69]
synonym: "urea hydro-lyase activity" RELATED [EC:4.2.1.69]
xref: EC:4.2.1.69
xref: KEGG_REACTION:R00778
xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN
xref: RHEA:23056
xref: UM-BBD_reactionID:r0668
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018822
name: nitrile hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [RHEA:12673]
synonym: "3-cyanopyridine hydratase activity" NARROW []
synonym: "acrylonitrile hydratase activity" RELATED []
synonym: "aliphatic nitrile hydratase activity" RELATED []
synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" RELATED []
synonym: "H-NHase activity" RELATED []
synonym: "L-NHase activity" RELATED []
synonym: "NHase activity" RELATED []
synonym: "nitrile hydro-lyase activity" RELATED [EC:4.2.1.84]
xref: EC:4.2.1.84
xref: MetaCyc:NITRILE-HYDRATASE-RXN
xref: RHEA:12673
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018823
name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-enecarbonyl-CoA." [EC:4.2.1.100, RHEA:21856]
synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100]
synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT []
synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" RELATED [EC:4.2.1.100]
synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" RELATED [EC:4.2.1.100]
synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.100]
synonym: "dienoyl-CoA hydratase activity" RELATED [EC:4.2.1.100]
xref: EC:4.2.1.100
xref: KEGG_REACTION:R05597
xref: MetaCyc:4.2.1.100-RXN
xref: RHEA:21856
xref: UM-BBD_reactionID:r0203
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018824
name: (hydroxyamino)benzene mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_reactionID:r0304]
synonym: "(hydroxyamino)benzene hydroxymutase activity" RELATED [EC:5.4.4.1]
synonym: "HAB mutase activity" RELATED [EC:5.4.4.1]
synonym: "hydroxylaminobenzene hydroxymutase activity" RELATED [EC:5.4.4.1]
synonym: "hydroxylaminobenzene mutase activity" RELATED [EC:5.4.4.1]
xref: MetaCyc:5.4.4.1-RXN
xref: RHEA:19245
xref: UM-BBD_reactionID:r0304
is_a: GO:0050486 ! intramolecular hydroxytransferase activity

[Term]
id: GO:0018825
name: obsolete triethanolamine lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018826
name: methionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11, RHEA:23800]
synonym: "L-methioninase activity" RELATED [EC:4.4.1.11]
synonym: "L-methionine gamma-lyase activity" RELATED [EC:4.4.1.11]
synonym: "L-methionine methanethiol-lyase (deaminating)" RELATED [EC:4.4.1.11]
synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" RELATED [EC:4.4.1.11]
synonym: "methioninase activity" RELATED [EC:4.4.1.11]
synonym: "methionine dethiomethylase activity" RELATED [EC:4.4.1.11]
synonym: "methionine lyase activity" RELATED [EC:4.4.1.11]
xref: EC:4.4.1.11
xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN
xref: RHEA:23800
xref: UM-BBD_reactionID:r0432
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0018827
name: obsolete 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_reactionID:r0515]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "DDMS dehydrochlorinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018828
name: obsolete halohydrin hydrogen-halide-lyase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018829
name: obsolete 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0513]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "DDD dehydrochlorinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018830
name: obsolete gamma-hexachlorocyclohexane dehydrochlorinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018831
name: obsolete 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_reactionID:r0666]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018832
name: obsolete halohydrin hydrogen-halide-lyase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018833
name: DDT-dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H+." [EC:4.5.1.1, RHEA:19217]
synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1]
synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" RELATED [EC:4.5.1.1]
synonym: "DDT dehydrochlorinase activity" EXACT []
synonym: "DDT-as" RELATED [EC:4.5.1.1]
synonym: "DDT-ase activity" RELATED [EC:4.5.1.1]
synonym: "DDTase activity" RELATED [EC:4.5.1.1]
xref: EC:4.5.1.1
xref: KEGG_REACTION:R04522
xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN
xref: RHEA:19217
xref: UM-BBD_reactionID:r0439
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018834
name: dichloromethane dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dichloromethane + H2O = 2 chloride + formaldehyde + 2 H+." [EC:4.5.1.3, RHEA:15397]
synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" RELATED [EC:4.5.1.3]
synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" RELATED [EC:4.5.1.3]
xref: EC:4.5.1.3
xref: KEGG_REACTION:R00603
xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN
xref: RHEA:15397
xref: UM-BBD_reactionID:r0188
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018835
name: carbon phosphorus lyase activity
namespace: molecular_function
alt_id: GO:0009456
def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [PMID:3804975]
xref: EC:4.7.1.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0018836
name: alkylmercury lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alkylmercury + H+ = an alkane + Hg2+." [RHEA:18777]
synonym: "alkylmercury mercuric-lyase (alkane-forming)" RELATED [EC:4.99.1.2]
synonym: "alkylmercury mercuric-lyase activity" RELATED [EC:4.99.1.2]
synonym: "organomercurial lyase activity" RELATED [EC:4.99.1.2]
synonym: "organomercury lyase activity" RELATED [EC:4.99.1.2]
xref: EC:4.99.1.2
xref: MetaCyc:ALKYLMERCURY-LYASE-RXN
xref: RHEA:18777
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0018837
name: obsolete 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018838
name: mandelate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2]
xref: EC:5.1.2.2
xref: MetaCyc:MANDELATE-RACEMASE-RXN
xref: RHEA:13945
xref: UM-BBD_reactionID:r0091
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0018839
name: obsolete cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0163]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018844
name: obsolete 2-hydroxytetrahydrofuran isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_reactionID:r0019]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018845
name: 2-hydroxychromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate." [RHEA:27401]
xref: EC:5.99.1.4
xref: KEGG_REACTION:R05137
xref: MetaCyc:RXNN-386
xref: RHEA:27401
xref: UM-BBD_reactionID:r0337
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018846
name: styrene-oxide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7, RHEA:21604]
synonym: "SOI activity" RELATED [EC:5.3.99.7]
synonym: "styrene oxide isomerase activity" EXACT []
synonym: "styrene-oxide isomerase (epoxide-cleaving)" RELATED [EC:5.3.99.7]
xref: EC:5.3.99.7
xref: KEGG_REACTION:R02615
xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN
xref: RHEA:21604
xref: UM-BBD_reactionID:r0034
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018847
name: obsolete alpha-pinene lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_reactionID:r0712]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true
consider: GO:0046249

[Term]
id: GO:0018848
name: obsolete pinocarveol isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_reactionID:r0715]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0018849
name: muconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [RHEA:30031]
synonym: "cis,cis-muconate cycloisomerase activity" RELATED [EC:5.5.1.1]
synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1]
synonym: "muconate cycloisomerase I activity" RELATED [EC:5.5.1.1]
synonym: "muconate lactonizing enzyme activity" RELATED [EC:5.5.1.1]
synonym: "muconate lactonizing enzyme I activity" RELATED [EC:5.5.1.1]
xref: EC:5.5.1.1
xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN
xref: RHEA:30031
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018850
name: chloromuconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7]
synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" RELATED [EC:5.5.1.7]
synonym: "muconate cycloisomerase II activity" RELATED [EC:5.5.1.7]
xref: EC:5.5.1.7
xref: RHEA:11032
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018851
name: alpha-pinene-oxide decyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10, RHEA:16693]
synonym: "alpha-pinene oxide lyase activity" EXACT []
synonym: "alpha-pinene-oxide lyase (decyclizing)" RELATED [EC:5.5.1.10]
xref: EC:5.5.1.10
xref: KEGG_REACTION:R04040
xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN
xref: RHEA:16693
xref: UM-BBD_reactionID:r0743
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018852
name: dichloromuconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11]
synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" RELATED [EC:5.5.1.11]
xref: EC:5.5.1.11
xref: MetaCyc:RXN-9856
xref: RHEA:17437
xref: UM-BBD_reactionID:r0277
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018853
name: obsolete perillyl-CoA synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_reactionID:r0731]
comment: This term was made obsolete because it represents two reactions.
synonym: "perillyl-CoA synthetase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0018854
name: obsolete 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018855
name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429]
xref: EC:6.2.1.38
xref: RHEA:33419
xref: UM-BBD_reactionID:r0429
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018856
name: benzoyl acetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_reactionID:r0242]
xref: KEGG_REACTION:R05452
xref: SABIO-RK:5058
xref: UM-BBD_reactionID:r0242
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018857
name: obsolete 2,4-dichlorobenzoate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018858
name: benzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate." [EC:6.2.1.25, RHEA:10132]
synonym: "benzoate-coenzyme A ligase activity" RELATED [EC:6.2.1.25]
synonym: "benzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.25]
synonym: "benzoyl CoA synthetase (AMP forming)" RELATED [EC:6.2.1.25]
synonym: "benzoyl-coenzyme A synthetase activity" RELATED [EC:6.2.1.25]
xref: EC:6.2.1.25
xref: KEGG_REACTION:R01422
xref: MetaCyc:BENZOATE--COA-LIGASE-RXN
xref: RHEA:10132
xref: UM-BBD_reactionID:r0189
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018859
name: 4-hydroxybenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27]
synonym: "4-hydroxybenzoate-CoA synthetase activity" RELATED [EC:6.2.1.27]
synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" RELATED [EC:6.2.1.27]
synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.27]
synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.27]
synonym: "4-hydroxybenzoyl-CoA ligase activity" RELATED [EC:6.2.1.27]
xref: EC:6.2.1.27
xref: KEGG_REACTION:R01300
xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN
xref: RHEA:23116
xref: UM-BBD_reactionID:r0156
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018860
name: anthranilate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32]
synonym: "2-aminobenzoate coenzyme A ligase activity" RELATED [EC:6.2.1.32]
synonym: "2-aminobenzoate-CoA ligase activity" RELATED [EC:6.2.1.32]
synonym: "2-aminobenzoate-coenzyme A ligase activity" RELATED [EC:6.2.1.32]
synonym: "anthranilate--CoA ligase activity" EXACT []
synonym: "anthranilate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.32]
synonym: "anthraniloyl coenzyme A synthetase activity" RELATED [EC:6.2.1.32]
xref: EC:6.2.1.32
xref: KEGG_REACTION:R00982
xref: MetaCyc:AMINOBENZCOALIG-RXN
xref: RHEA:10828
xref: UM-BBD_reactionID:r0341
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018861
name: 4-chlorobenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33]
synonym: "4-chlorobenzoate:CoA ligase activity" EXACT []
xref: EC:6.2.1.33
xref: KEGG_REACTION:R03932
xref: MetaCyc:6.2.1.33-RXN
xref: RHEA:23220
xref: UM-BBD_reactionID:r0139
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018862
name: phenyl-phosphate phosphatase/carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + H+ + phosphate = CO2 + H2O + phenyl phosphate." [RHEA:74015]
synonym: "phenylphosphate carboxylase activity" EXACT []
xref: EC:4.1.1.123
xref: KEGG_REACTION:R05603
xref: MetaCyc:PHENYLPCARB-RXN
xref: RHEA:74015
xref: UM-BBD_reactionID:r0157
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018863
name: obsolete phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0018864
name: acetylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544]
synonym: "acetylene metabolism" EXACT []
synonym: "ethyne metabolic process" EXACT []
synonym: "ethyne metabolism" EXACT []
xref: UM-BBD_pathwayID:atl
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043452 ! alkyne metabolic process
is_a: GO:0120244 ! terminal acetylenic compound metabolic process

[Term]
id: GO:0018865
name: obsolete acrylonitrile metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [PMID:1390687, PMID:3830164]
comment: The reason for obsoletion is that this term is an unnecessary grouping term. The chemical is not naturally made by any organism.
synonym: "acrylonitrile metabolism" BROAD []
is_obsolete: true
replaced_by: GO:0019256

[Term]
id: GO:0018866
name: adamantanone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai]
synonym: "adamantanone metabolism" EXACT []
xref: UM-BBD_pathwayID:ada
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0018867
name: alpha-pinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [UM-BBD_pathwayID:apn]
synonym: "alpha-pinene metabolism" EXACT []
xref: UM-BBD_pathwayID:apn
is_a: GO:0033073 ! pinene metabolic process

[Term]
id: GO:0018868
name: 2-aminobenzenesulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:curators]
synonym: "2-aminobenzenesulfonate metabolism" EXACT []
synonym: "2-aminobenzenesulphonate metabolic process" EXACT []
synonym: "2-aminobenzenesulphonate metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018870
name: anaerobic 2-aminobenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai]
synonym: "anaerobic 2-aminobenzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:abz
is_a: GO:0018875 ! anaerobic benzoate metabolic process
is_a: GO:0043420 ! anthranilate metabolic process

[Term]
id: GO:0018871
name: 1-aminocyclopropane-1-carboxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [UM-BBD_pathwayID:acp]
synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT []
synonym: "ACP metabolic process" EXACT []
synonym: "ACP metabolism" EXACT []
xref: UM-BBD_pathwayID:acp
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0018872
name: arsonoacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [UM-BBD_pathwayID:ara]
synonym: "arsonoacetate metabolism" EXACT []
xref: UM-BBD_pathwayID:ara
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0018873
name: atrazine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [GOC:curators]
synonym: "atrazine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0018965 ! s-triazine compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018874
name: benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544]
synonym: "benzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:benz2
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018875
name: anaerobic benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai]
synonym: "anaerobic benzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:benz
is_a: GO:0018874 ! benzoate metabolic process

[Term]
id: GO:0018876
name: benzonitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn]
synonym: "benzonitrile metabolism" EXACT []
xref: UM-BBD_pathwayID:bzn
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018877
name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch]
synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
xref: UM-BBD_pathwayID:hch
is_a: GO:0019497 ! hexachlorocyclohexane metabolic process

[Term]
id: GO:0018878
name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai]
synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process

[Term]
id: GO:0018879
name: biphenyl metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl]
synonym: "biphenyl metabolism" EXACT []
synonym: "xenene metabolic process" EXACT []
synonym: "xenene metabolism" EXACT []
xref: UM-BBD_pathwayID:bph
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018880
name: 4-chlorobiphenyl metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl]
synonym: "4-chlorobiphenyl metabolism" EXACT []
xref: UM-BBD_pathwayID:cbp
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018881
name: bromoxynil metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai]
synonym: "bromoxynil metabolism" EXACT []
xref: UM-BBD_pathwayID:box
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018882
name: (+)-camphor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [GOC:curators]
synonym: "(+)-camphor metabolism" EXACT []
synonym: "camphor metabolic process" EXACT []
synonym: "camphor metabolism" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0018883
name: caprolactam metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [GOC:curators]
synonym: "caprolactam metabolism" EXACT []
xref: UM-BBD_pathwayID:cap
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:0018884
name: carbazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl]
synonym: "CAR metabolic process" EXACT []
synonym: "CAR metabolism" EXACT []
synonym: "carbazole metabolism" EXACT []
xref: UM-BBD_pathwayID:car
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0018885
name: carbon tetrachloride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [UM-BBD_pathwayID:ctc]
synonym: "carbon tetrachloride metabolism" EXACT []
xref: UM-BBD_pathwayID:ctc
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018886
name: anaerobic carbon tetrachloride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai]
synonym: "anaerobic carbon tetrachloride metabolism" EXACT []
xref: UM-BBD_pathwayID:ctc
is_a: GO:0018885 ! carbon tetrachloride metabolic process

[Term]
id: GO:0018887
name: 4-carboxy-4'-sulfoazobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860]
synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT []
synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT []
synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:csab
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018888
name: 3-chloroacrylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai]
synonym: "3-chloroacrylic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:caa
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018889
name: 2-chloro-N-isopropylacetanilide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [UM-BBD_pathwayID:ppc]
synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT []
synonym: "propachlor metabolic process" EXACT []
synonym: "propachlor metabolism" EXACT []
xref: UM-BBD_pathwayID:ppc
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018890
name: cyanamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [GOC:curators]
synonym: "cyanamide metabolism" EXACT []
xref: UM-BBD_pathwayID:cnm
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018891
name: cyclohexanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544]
synonym: "cyclohexanol metabolism" EXACT []
xref: UM-BBD_pathwayID:chx
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0018892
name: cyclohexylsulfamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs]
synonym: "cyclohexylsulfamate metabolism" EXACT []
synonym: "cyclohexylsulphamate metabolic process" EXACT []
synonym: "cyclohexylsulphamate metabolism" EXACT []
xref: UM-BBD_pathwayID:chs
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0018893
name: dibenzofuran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf]
synonym: "dibenzofuran metabolism" EXACT []
xref: UM-BBD_pathwayID:dbf
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0018894
name: dibenzo-p-dioxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd]
synonym: "dibenzo-p-dioxin metabolism" EXACT []
synonym: "oxanthrene metabolic process" EXACT []
synonym: "oxanthrene metabolism" EXACT []
synonym: "phenodioxin metabolic process" EXACT []
synonym: "phenodioxin metabolism" EXACT []
xref: UM-BBD_pathwayID:dpd
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0018895
name: dibenzothiophene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483]
synonym: "dibenzothiophene metabolism" EXACT []
synonym: "diphenylene sulfide metabolic process" EXACT []
synonym: "diphenylene sulfide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0018896
name: dibenzothiophene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]
synonym: "dibenzothiophene breakdown" EXACT []
synonym: "dibenzothiophene catabolism" EXACT []
synonym: "dibenzothiophene degradation" EXACT []
xref: UM-BBD_pathwayID:dbt2
is_a: GO:0018895 ! dibenzothiophene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0018897
name: dibenzothiophene desulfurization
namespace: biological_process
def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]
synonym: "dibenzothiophene desulphurization" EXACT []
xref: MetaCyc:PWY-681
xref: UM-BBD_pathwayID:dbt
is_a: GO:0018895 ! dibenzothiophene metabolic process

[Term]
id: GO:0018898
name: 2,4-dichlorobenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, UM-BBD_pathwayID:dcb]
synonym: "2,4-dichlorobenzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:dcb
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018899
name: 1,2-dichloroethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl]
synonym: "1,2-dichloroethane metabolism" EXACT []
xref: UM-BBD_pathwayID:dce
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018900
name: dichloromethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm]
synonym: "dichloromethane metabolism" EXACT []
xref: UM-BBD_pathwayID:dcm
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018901
name: 2,4-dichlorophenoxyacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:curators]
synonym: "2,4-D metabolic process" EXACT []
synonym: "2,4-D metabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018902
name: obsolete 1,3-dichloro-2-propanol metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, UM-BBD_pathwayID:dcp]
comment: 1,3-dichloro-2-propanol is not a natural compound.
synonym: "1,3-dichloro-2-propanol metabolism" EXACT []
synonym: "DCP metabolic process" EXACT []
synonym: "DCP metabolism" EXACT []
is_obsolete: true
consider: GO:0006805

[Term]
id: GO:0018903
name: 1,3-dichloropropene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [UM-BBD_pathwayID:cpr]
synonym: "1,3-dichloropropene metabolism" EXACT []
synonym: "1,3-dichloropropylene metabolic process" EXACT []
synonym: "1,3-dichloropropylene metabolism" EXACT []
synonym: "gamma-chloroallylchloride metabolic process" EXACT []
synonym: "gamma-chloroallylchloride metabolism" EXACT []
xref: UM-BBD_pathwayID:cpr
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018904
name: ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [GOC:pr, ISBN:0198506732]
subset: goslim_pir
synonym: "ether metabolism" EXACT []
synonym: "organic ether metabolic process" EXACT []
synonym: "organic ether metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0018905
name: dimethyl ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme]
synonym: "dimethyl ether metabolism" EXACT []
synonym: "methyl ether metabolic process" EXACT []
synonym: "methyl ether metabolism" EXACT []
xref: UM-BBD_pathwayID:dme
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:0018906
name: methyl tert-butyl ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb]
synonym: "methyl tert-butyl ether metabolism" EXACT []
xref: UM-BBD_pathwayID:mtb
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:0018907
name: dimethyl sulfoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [GOC:curators]
synonym: "dimethyl sulfoxide metabolism" EXACT []
synonym: "dimethyl sulphoxide metabolic process" EXACT []
synonym: "dimethyl sulphoxide metabolism" EXACT []
synonym: "DMSO metabolic process" EXACT []
synonym: "DMSO metabolism" EXACT []
xref: UM-BBD_pathwayID:sulf
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0018908
name: obsolete organosulfide cycle
namespace: biological_process
def: "OBSOLETE. A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle." [UM-BBD_pathwayID:sulf]
comment: This term was obsoleted because it corresponds to a detoxification process; consider annotating to cellular detoxification ; GO:1990748.
synonym: "organosulphide cycle" EXACT []
is_obsolete: true
consider: GO:1990748

[Term]
id: GO:0018909
name: dodecyl sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds]
synonym: "dodecyl sulfate metabolism" EXACT []
synonym: "dodecyl sulphate metabolic process" EXACT []
synonym: "dodecyl sulphate metabolism" EXACT []
xref: UM-BBD_pathwayID:dds
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0018910
name: benzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [GOC:ai]
synonym: "benzene metabolism" EXACT []
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0018911
name: 1,2,4-trichlorobenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [PMID:1987135]
synonym: "1,2,4-trichlorobenzene metabolic process" BROAD []
synonym: "1,2,4-trichlorobenzene metabolism" BROAD []
xref: UM-BBD_pathwayID:tbz
is_a: GO:0009056 ! catabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018912
name: obsolete 1,4-dichlorobenzene metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [PMID:9148781]
comment: The reason for obsoletion is that this term is an unnecessary grouping term. The chemical is not naturally made by any organism.
synonym: "1,4-dichlorobenzene metabolism" BROAD []
is_obsolete: true
replaced_by: GO:0019261

[Term]
id: GO:0018913
name: obsolete anaerobic ethylbenzene metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai]
comment: The reason for obsoletion is that this term is an unnecessary grouping term. The chemical is not naturally made by any organism.
synonym: "anaerobic ethylbenzene metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0010130

[Term]
id: GO:0018914
name: chlorobenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [PMID:10808489, PMID:8626733]
synonym: "chlorobenzene metabolic process" BROAD []
synonym: "chlorobenzene metabolism" BROAD []
xref: UM-BBD_pathwayID:cb
is_a: GO:0009056 ! catabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018915
name: ethylbenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [PMID:8795196]
synonym: "ethylbenzene metabolic process" BROAD []
synonym: "ethylbenzene metabolism" BROAD []
xref: UM-BBD_pathwayID:ethb2
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0018916
name: nitrobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [GOC:curators]
synonym: "nitrobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:nb
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018919
name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch]
synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
xref: MetaCyc:GAMMAHEXCHLORDEG-PWY
xref: UM-BBD_pathwayID:ghch
is_a: GO:0019497 ! hexachlorocyclohexane metabolic process

[Term]
id: GO:0018920
name: glyphosate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [UM-BBD_pathwayID:gly]
synonym: "glyphosate metabolism" EXACT []
synonym: "Roundup metabolic process" EXACT []
synonym: "Roundup metabolism" EXACT []
xref: UM-BBD_pathwayID:gly
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0018921
name: 3-hydroxybenzyl alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [UM-BBD_pathwayID:mcr]
synonym: "3-hydroxybenzyl alcohol metabolism" EXACT []
xref: UM-BBD_pathwayID:mcr
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0018922
name: iprodione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd]
synonym: "iprodione metabolism" EXACT []
xref: UM-BBD_pathwayID:ipd
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018923
name: limonene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UM-BBD_pathwayID:lim]
synonym: "limonene metabolism" EXACT []
xref: UM-BBD_pathwayID:lim
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:0018924
name: mandelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl]
synonym: "mandelate metabolism" EXACT []
synonym: "mandelic acid metabolic process" EXACT []
synonym: "mandelic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:mca
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0018925
name: m-cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl]
synonym: "3-hydroxytoluene metabolic process" EXACT []
synonym: "3-hydroxytoluene metabolism" EXACT []
synonym: "m-cresol metabolism" EXACT []
synonym: "meta-cresol metabolic process" EXACT []
synonym: "meta-cresol metabolism" EXACT []
xref: UM-BBD_pathwayID:mcr
is_a: GO:0042212 ! cresol metabolic process

[Term]
id: GO:0018926
name: methanesulfonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa]
synonym: "methanesulfonic acid metabolism" EXACT []
synonym: "methanesulphonic acid metabolic process" EXACT []
synonym: "methanesulphonic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:msa
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0019694 ! alkanesulfonate metabolic process

[Term]
id: GO:0018927
name: obsolete methionine and threonine metabolic process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule.
synonym: "methionine and threonine metabolic process" EXACT []
is_obsolete: true
consider: GO:0006555
consider: GO:0006566

[Term]
id: GO:0018928
name: methyl ethyl ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [UM-BBD_pathwayID:mek]
synonym: "2-butanone metabolic process" EXACT []
synonym: "2-butanone metabolism" EXACT []
synonym: "MEK metabolic process" EXACT []
synonym: "MEK metabolism" EXACT []
synonym: "methyl ethyl ketone metabolism" EXACT []
xref: UM-BBD_pathwayID:mek
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0018929
name: methyl fluoride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf]
synonym: "methyl fluoride metabolism" EXACT []
xref: UM-BBD_pathwayID:mf
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process
is_a: GO:0090346 ! organofluorine metabolic process

[Term]
id: GO:0018930
name: 3-methylquinoline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai]
synonym: "3-methylquinoline metabolism" EXACT []
xref: UM-BBD_pathwayID:mqn
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0018933
name: nicotine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
synonym: "nicotine metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0018934
name: nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta]
synonym: "nitrilotriacetate metabolism" EXACT []
xref: UM-BBD_pathwayID:nta
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0018935
name: aerobic nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai]
synonym: "aerobic nitrilotriacetate metabolism" EXACT []
is_a: GO:0018934 ! nitrilotriacetate metabolic process

[Term]
id: GO:0018936
name: anaerobic nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai]
synonym: "anaerobic nitrilotriacetate metabolism" EXACT []
is_a: GO:0018934 ! nitrilotriacetate metabolic process

[Term]
id: GO:0018937
name: nitroglycerin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [UM-BBD_pathwayID:ng]
synonym: "NG metabolic process" EXACT []
synonym: "NG metabolism" EXACT []
synonym: "nitroglycerin metabolism" EXACT []
xref: MetaCyc:P201-PWY
xref: UM-BBD_pathwayID:ng
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018938
name: 2-nitropropane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [UM-BBD_pathwayID:npp]
synonym: "2-nitropropane metabolism" EXACT []
xref: MetaCyc:PWY-723
xref: UM-BBD_pathwayID:npp
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018939
name: n-octane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct]
synonym: "n-octane metabolism" EXACT []
xref: UM-BBD_pathwayID:oct
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043446 ! alkane metabolic process

[Term]
id: GO:0018940
name: orcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl]
synonym: "orcin metabolic process" EXACT []
synonym: "orcin metabolism" EXACT []
synonym: "orcinol metabolism" EXACT []
xref: MetaCyc:P342-PWY
xref: UM-BBD_pathwayID:orc
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0018941
name: obsolete organomercury metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "organomercury metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0018942
name: organometal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732]
subset: goslim_pir
synonym: "organometal metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0018943
name: organotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732]
synonym: "organotin metabolism" EXACT []
is_a: GO:0018942 ! organometal metabolic process

[Term]
id: GO:0018944
name: tri-n-butyltin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt]
synonym: "tri-n-butyltin metabolism" EXACT []
xref: UM-BBD_pathwayID:tbt
is_a: GO:0018943 ! organotin metabolic process

[Term]
id: GO:0018945
name: organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl]
synonym: "organosilicon metabolism" EXACT []
synonym: "organosilicone metabolic process" EXACT []
synonym: "organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018946
name: aerobic organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl]
synonym: "aerobic organosilicon metabolism" EXACT []
synonym: "aerobic organosilicone metabolic process" EXACT []
synonym: "aerobic organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018945 ! organosilicon metabolic process

[Term]
id: GO:0018947
name: anaerobic organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl]
synonym: "anaerobic organosilicon metabolism" EXACT []
synonym: "anaerobic organosilicone metabolic process" EXACT []
synonym: "anaerobic organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018945 ! organosilicon metabolic process

[Term]
id: GO:0018948
name: xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl]
synonym: "xylene metabolism" EXACT []
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0018949
name: m-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
synonym: "m-xylene metabolism" EXACT []
synonym: "meta-xylene metabolic process" EXACT []
synonym: "meta-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:mxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018950
name: o-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
synonym: "o-xylene metabolism" EXACT []
synonym: "ortho-xylene metabolic process" EXACT []
synonym: "ortho-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:oxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018951
name: p-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
synonym: "p-xylene metabolism" EXACT []
synonym: "para-xylene metabolic process" EXACT []
synonym: "para-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:pxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018952
name: parathion metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [GOC:curators]
synonym: "parathion metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0018953
name: p-cymene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy]
synonym: "p-cymene metabolism" EXACT []
xref: UM-BBD_pathwayID:pcy
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0018954
name: pentaerythritol tetranitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn]
synonym: "pentaerythritol tetranitrate metabolism" EXACT []
xref: UM-BBD_pathwayID:petn
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018955
name: phenanthrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, UM-BBD_pathwayID:pha]
synonym: "phenanthrene metabolism" EXACT []
xref: UM-BBD_pathwayID:pha
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0018956
name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha3]
synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT []
synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT []
xref: UM-BBD_pathwayID:pha3
is_a: GO:0042216 ! phenanthrene catabolic process

[Term]
id: GO:0018957
name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha2]
synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT []
synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT []
xref: UM-BBD_pathwayID:pha2
is_a: GO:0042216 ! phenanthrene catabolic process

[Term]
id: GO:0018958
name: phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]
comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds.
synonym: "carbolic acid metabolic process" EXACT []
synonym: "carbolic acid metabolism" EXACT []
synonym: "hydroxybenzene metabolic process" EXACT []
synonym: "hydroxybenzene metabolism" EXACT []
synonym: "phenol-containing compound metabolism" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0018959
name: aerobic phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [ISBN:0198506732]
synonym: "aerobic phenol-containing compound metabolism" EXACT []
xref: UM-BBD_pathwayID:pba
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0018960
name: 4-nitrophenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl]
synonym: "4-nitrophenol metabolism" EXACT []
synonym: "p-nitrophenol metabolic process" EXACT []
synonym: "p-nitrophenol metabolism" EXACT []
xref: UM-BBD_pathwayID:nphe
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0018961
name: pentachlorophenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [UM-BBD_pathwayID:pcp]
synonym: "PCP metabolic process" EXACT []
synonym: "PCP metabolism" EXACT []
synonym: "pentachlorophenol metabolism" EXACT []
xref: UM-BBD_pathwayID:pcp
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018962
name: 3-phenylpropionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa]
synonym: "3-phenylpropionate metabolism" EXACT []
synonym: "hydrocinnamic acid metabolic process" EXACT []
synonym: "hydrocinnamic acid metabolism" EXACT []
synonym: "phenylpropanoate metabolic process" EXACT []
synonym: "phenylpropanoate metabolism" EXACT []
xref: UM-BBD_pathwayID:ppa
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018963
name: phthalate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [UM-BBD_pathwayID:pth]
synonym: "phthalate metabolism" EXACT []
synonym: "phthalic acid metabolic process" EXACT []
synonym: "phthalic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:pth
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018964
name: propylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl]
synonym: "propylene metabolism" EXACT []
xref: UM-BBD_pathwayID:pro
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:0018965
name: s-triazine compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria]
synonym: "s-triazine compound metabolism" EXACT []
xref: UM-BBD_pathwayID:tria
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018966
name: styrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, UM-BBD_pathwayID:sty]
synonym: "styrene metabolism" EXACT []
xref: UM-BBD_pathwayID:sty
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120252 ! hydrocarbon metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0018967
name: obsolete tetrachloroethylene metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm]
comment: The reason for obsoletion is that this term is an unnecessary grouping term. The chemical is not naturally made by any organism.
synonym: "tetrachloroethene metabolic process" EXACT []
synonym: "tetrachloroethene metabolism" EXACT []
synonym: "tetrachloroethylene metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0019337

[Term]
id: GO:0018968
name: tetrahydrofuran catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [PMID:12632259, PMID:33362743, PMID:35108100]
synonym: "tetrahydrofuran metabolic process" BROAD []
synonym: "tetrahydrofuran metabolism" BROAD []
synonym: "THF metabolic process" BROAD []
synonym: "THF metabolism" BROAD []
xref: UM-BBD_pathwayID:thf
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0009056 ! catabolic process
is_a: GO:0097176 ! epoxide metabolic process

[Term]
id: GO:0018969
name: thiocyanate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl]
synonym: "thiocyanate metabolism" EXACT []
synonym: "thiocyanic acid metabolic process" EXACT []
synonym: "thiocyanic acid metabolism" EXACT []
xref: MetaCyc:P581-PWY
xref: UM-BBD_pathwayID:thc
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018970
name: toluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [GOC:curators]
synonym: "methylbenzene metabolic process" EXACT []
synonym: "methylbenzene metabolism" EXACT []
synonym: "toluene metabolism" EXACT []
is_a: GO:0072490 ! toluene-containing compound metabolic process
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0018971
name: anaerobic toluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai]
synonym: "anaerobic toluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tol2
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0018972
name: toluene-4-sulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai]
synonym: "4-methylbenzenesulfonate metabolic process" EXACT []
synonym: "4-methylbenzenesulfonate metabolism" EXACT []
synonym: "4-toluenesulfonate metabolic process" EXACT []
synonym: "4-toluenesulfonate metabolism" EXACT []
synonym: "toluene-4-sulfonate metabolism" EXACT []
synonym: "toluene-4-sulphonate metabolic process" EXACT []
synonym: "toluene-4-sulphonate metabolism" EXACT []
xref: MetaCyc:TOLSULFDEG-PWY
xref: UM-BBD_pathwayID:tsa
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0018973
name: trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
synonym: "trinitrotoluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tnt
is_a: GO:0019326 ! nitrotoluene metabolic process

[Term]
id: GO:0018974
name: 2,4,6-trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767]
synonym: "2,4,6-trinitrotoluene metabolism" EXACT []
synonym: "TNT metabolic process" EXACT []
synonym: "TNT metabolism" EXACT []
is_a: GO:0018973 ! trinitrotoluene metabolic process

[Term]
id: GO:0018975
name: anaerobic 2,4,6-trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai]
synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tnt2
is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0018976
name: 1,2,3-tribromopropane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl]
synonym: "1,2,3-tribromopropane metabolism" EXACT []
xref: UM-BBD_pathwayID:tbp
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018977
name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl]
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT []
synonym: "DDT metabolic process" EXACT []
synonym: "DDT metabolism" EXACT []
xref: UM-BBD_pathwayID:ddt
is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018978
name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl]
synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT []
synonym: "anaerobic DDT metabolic process" EXACT []
synonym: "anaerobic DDT metabolism" EXACT []
xref: UM-BBD_pathwayID:ddt2
is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process

[Term]
id: GO:0018979
name: trichloroethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl]
synonym: "TCE metabolic process" EXACT []
synonym: "TCE metabolism" EXACT []
synonym: "trichloroethene metabolic process" EXACT []
synonym: "trichloroethene metabolism" EXACT []
synonym: "trichloroethylene metabolism" EXACT []
xref: UM-BBD_pathwayID:tce
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018980
name: 2,4,5-trichlorophenoxyacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t]
synonym: "2,4,5-T metabolic process" EXACT []
synonym: "2,4,5-T metabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:2\,4\,5-t
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0018981
name: obsolete triethanolamine metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl]
comment: Triethanolamine is not a natural compound.
synonym: "triethanolamine metabolism" EXACT []
is_obsolete: true
consider: GO:0006805

[Term]
id: GO:0018982
name: vanillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl]
synonym: "vanillic aldehyde metabolic process" EXACT []
synonym: "vanillic aldehyde metabolism" EXACT []
synonym: "vanillin metabolism" EXACT []
xref: UM-BBD_pathwayID:van
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018983
name: Z-phenylacetaldoxime metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:pao]
synonym: "Z-phenylacetaldoxime metabolism" EXACT []
xref: UM-BBD_pathwayID:pao
is_a: GO:0019330 ! aldoxime metabolic process

[Term]
id: GO:0018984
name: naphthalenesulfonate metabolic process
namespace: biological_process
alt_id: GO:0018932
def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai]
synonym: "naphthalenesulfonate metabolism" EXACT []
synonym: "naphthalenesulphonate metabolic process" EXACT []
synonym: "naphthalenesulphonate metabolism" EXACT []
xref: UM-BBD_pathwayID:nphs
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0018985
name: pronuclear envelope synthesis
namespace: biological_process
def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems]
is_a: GO:0006998 ! nuclear envelope organization
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0018988
name: obsolete molting cycle, protein-based cuticle
namespace: biological_process
def: "OBSOLETE. The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "protein-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0007591
consider: GO:0018996

[Term]
id: GO:0018989
name: apolysis
namespace: biological_process
def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl]
xref: Wikipedia:Apolysis
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0018990
name: ecdysis, chitin-based cuticle
namespace: biological_process
def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0018991
name: egg-laying behavior
namespace: biological_process
alt_id: GO:0060403
def: "A reproductive behavior that results in the deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems, PMID:18050396, PMID:31164023]
synonym: "egg laying" BROAD []
synonym: "egg-laying" BROAD []
synonym: "oviposition" EXACT []
synonym: "post-mating oviposition" NARROW []
xref: Wikipedia:Oviposition
is_a: GO:0019098 ! reproductive behavior

[Term]
id: GO:0018992
name: germ-line sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0018993
name: somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0018995
name: host cellular component
namespace: cellular_component
def: "Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732]
synonym: "host organism" EXACT []
xref: Wikipedia:Host_(biology)
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0018996
name: molting cycle, collagen and cuticulin-based cuticle
namespace: biological_process
def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu]
synonym: "collagen and cuticulin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0018997
name: obsolete electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the parent terms cover its function.
synonym: "electron transfer carrier" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0018998
name: obsolete metaxin
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "metaxin" EXACT []
is_obsolete: true
consider: GO:0005741

[Term]
id: GO:0019000
name: obsolete endonuclease G activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691]
comment: This term was made obsolete because it represents a gene product.
synonym: "endonuclease G activity" EXACT []
is_obsolete: true
consider: GO:0004520
consider: GO:0004521

[Term]
id: GO:0019001
name: guanyl nucleotide binding
namespace: molecular_function
def: "Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]
xref: Reactome:R-HSA-156909 "eEF1A complexes with GTP"
is_a: GO:0017076 ! purine nucleotide binding

[Term]
id: GO:0019002
name: GMP binding
namespace: molecular_function
def: "Binding to GMP, guanosine monophosphate." [GOC:ai]
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0019003
name: GDP binding
namespace: molecular_function
def: "Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0019005
name: SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "CDL1 complex" EXACT []
synonym: "CRL1 complex" EXACT []
synonym: "Cul1-RING ubiquitin ligase complex" EXACT []
synonym: "cullin-RING ligase 1" EXACT []
synonym: "SCF complex" EXACT []
synonym: "SCF complex substrate recognition subunit" NARROW []
synonym: "Skp1/Cul1/F-box protein complex" EXACT []
xref: Wikipedia:SCF_complex
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0019008
name: obsolete molybdopterin synthase complex
namespace: cellular_component
alt_id: GO:0019009
def: "OBSOLETE. A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772]
comment: The reason for obsoletion is that this term is equivalent to GO:1990140 MPT synthase complex.
synonym: "molybdopterin converting factor complex" EXACT []
is_obsolete: true
replaced_by: GO:1990140

[Term]
id: GO:0019010
name: farnesoic acid O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine. Also converts juvenile hormone III carboxylate into juvenile hormone-III." [EC:2.1.1.325, PMID:12135499, PMID:14530389, PMID:18549957]
synonym: "juvenile hormone acid methyltransferase activity" EXACT []
synonym: "juvenile hormone-III synthase activity" EXACT []
synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT []
xref: EC:2.1.1.325
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0019011
name: obsolete DNA replication accessory factor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA replication accessory factor" EXACT []
is_obsolete: true
consider: GO:0006260

[Term]
id: GO:0019013
name: viral nucleocapsid
namespace: cellular_component
alt_id: GO:0019014
def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
subset: goslim_chembl
synonym: "core" BROAD []
synonym: "nucleocapsid" EXACT []
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0019015
name: obsolete viral genome
namespace: cellular_component
def: "OBSOLETE. The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019016
name: obsolete non-segmented viral genome
namespace: cellular_component
def: "OBSOLETE. A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019017
name: obsolete segmented viral genome
namespace: cellular_component
def: "OBSOLETE. A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019018
name: obsolete bipartite viral genome
namespace: cellular_component
def: "OBSOLETE. A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019019
name: obsolete tripartite viral genome
namespace: cellular_component
def: "OBSOLETE. A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019020
name: obsolete multipartite viral genome
namespace: cellular_component
def: "OBSOLETE. A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019021
name: obsolete DNA viral genome
namespace: cellular_component
def: "OBSOLETE. A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019022
name: obsolete RNA viral genome
namespace: cellular_component
def: "OBSOLETE. A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019023
name: obsolete dsRNA viral genome
namespace: cellular_component
def: "OBSOLETE. A viral genome composed of double stranded RNA." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019024
name: obsolete ssRNA viral genome
namespace: cellular_component
def: "OBSOLETE. A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019025
name: obsolete positive sense viral genome
namespace: cellular_component
def: "OBSOLETE. A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019026
name: obsolete negative sense viral genome
namespace: cellular_component
def: "OBSOLETE. A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019027
name: obsolete ambisense viral genome
namespace: cellular_component
def: "OBSOLETE. A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
is_obsolete: true

[Term]
id: GO:0019028
name: viral capsid
namespace: cellular_component
alt_id: GO:0046728
def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_virus
xref: Wikipedia:Capsid
is_a: GO:0044423 ! virion component

[Term]
id: GO:0019029
name: helical viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X, UniProtKB-KW:KW-1139, VZ:885]
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019030
name: icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure." [GOC:bm, ISBN:0198506732, ISBN:071673706X, VZ:885, Wikipedia:Capsid]
synonym: "quasispherical viral capsid" EXACT []
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019031
name: viral envelope
namespace: cellular_component
def: "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
subset: goslim_chembl
synonym: "viral glycoprotein" RELATED []
synonym: "viral outside membrane" EXACT []
xref: Wikipedia:Viral_envelope
is_a: GO:0036338 ! viral membrane

[Term]
id: GO:0019032
name: obsolete viral glycoprotein
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a type of gene product and not a location or complex.
synonym: "viral glycoprotein" EXACT []
is_obsolete: true
consider: GO:0019031

[Term]
id: GO:0019033
name: viral tegument
namespace: cellular_component
def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544]
xref: Wikipedia:Viral_tegument
is_a: GO:0044423 ! virion component

[Term]
id: GO:0019034
name: viral replication complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325]
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0019035
name: viral integration complex
namespace: cellular_component
def: "A nucleoprotein complex containing viral genetic material and the viral integrase, required for genome integration into the host's genome. May contain other proteins." [PMID:21037296, PMID:2721960, PMID:29900498]
synonym: "PIC" BROAD []
synonym: "pre-integration complex" EXACT []
xref: Wikipedia:Pre-integration_complex
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0043657 ! host cell

[Term]
id: GO:0019036
name: viral transcriptional complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0019037
name: obsolete viral assembly intermediate
namespace: cellular_component
def: "OBSOLETE. Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325]
comment: This term was obsoleted because the concept it represented was too vague.
is_obsolete: true

[Term]
id: GO:0019038
name: obsolete provirus
namespace: cellular_component
def: "OBSOLETE. The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336]
comment: This term was obsoleted because it does not represent a GO cellular component.
xref: Wikipedia:Provirus
is_obsolete: true

[Term]
id: GO:0019039
name: obsolete viral-cell fusion molecule activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "viral-cell fusion molecule activity" EXACT []
is_obsolete: true
consider: GO:0019064
consider: GO:0050839

[Term]
id: GO:0019040
name: obsolete viral host shutoff protein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "viral host shutoff protein" EXACT []
is_obsolete: true
consider: GO:0004534
consider: GO:0019057

[Term]
id: GO:0019042
name: viral latency
namespace: biological_process
alt_id: GO:0030069
alt_id: GO:0075710
def: "The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate." [GOC:jl, VZ:3970]
synonym: "latent virus infection" EXACT []
synonym: "phage lysogeny" EXACT []
synonym: "viral dormancy" EXACT []
xref: VZ:3970 "Viral latency"
is_a: GO:0016032 ! viral process

[Term]
id: GO:0019043
name: establishment of viral latency
namespace: biological_process
alt_id: GO:0075601
def: "A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects." [GOC:jl]
synonym: "lysogenic commitment" EXACT []
synonym: "phage lysogeny" NARROW []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019042 ! viral latency

[Term]
id: GO:0019044
name: maintenance of viral latency
namespace: biological_process
alt_id: GO:0032360
alt_id: GO:0075716
def: "The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms." [GOC:jl]
synonym: "latent virus maintenance" EXACT []
synonym: "prophage maintenance" EXACT []
synonym: "provirus maintenance" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019042 ! viral latency

[Term]
id: GO:0019045
name: latent virus replication
namespace: biological_process
def: "Any process required for latent viral replication in a cell." [ISBN:0781702534]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019042 ! viral latency

[Term]
id: GO:0019046
name: release from viral latency
namespace: biological_process
alt_id: GO:0075717
def: "The process by which a virus begins to replicate following a latency replication decision (switch)." [GOC:dos, GOC:jl]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019045 ! latent virus replication

[Term]
id: GO:0019048
name: obsolete modulation by virus of host process
namespace: biological_process
alt_id: GO:0044661
alt_id: GO:0044792
def: "OBSOLETE. The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]
comment: This term has been replaced by the more general symbiont-mediated perturbation of host process ; GO:0044003.
synonym: "disruption by virus of host cell" RELATED []
synonym: "host-virus interaction" EXACT [GOC:bf, GOC:jl]
synonym: "modulation by virus of host anatomical structure or process" RELATED [GOC:bf, GOC:jl]
synonym: "modulation by virus of host anatomy or process" EXACT [GOC:bf, GOC:jl]
synonym: "modulation by virus of host morphology or physiology" RELATED []
synonym: "viral interaction with host" EXACT []
synonym: "viral-host process" EXACT [GOC:bf, GOC:jl]
synonym: "virus-host interaction" BROAD [GOC:bf, GOC:jl]
synonym: "virus-host process" EXACT [GOC:bf, GOC:jl]
xref: VZ:886 "Vertebrate host-virus interactions"
is_obsolete: true
replaced_by: GO:0044003

[Term]
id: GO:0019049
name: obsolete virus-mediated perturbation of host defense response
namespace: biological_process
alt_id: GO:0019052
alt_id: GO:0019053
alt_id: GO:0030683
alt_id: GO:0050690
def: "OBSOLETE. A process in which a virus interferes with the ability of the host to mount a defense in response to its presence. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272]
comment: This term was obsoleted because it represents the same process as symbiont-mediated perturbation of host defense response ; GO:0052031.
synonym: "evasion of host defenses by virus" NARROW []
synonym: "mitigation of host antiviral defense response" NARROW []
synonym: "mitigation of host defenses by virus" EXACT []
synonym: "perturbation of host defense response by virus" EXACT []
synonym: "regulation by virus of antiviral response" NARROW []
synonym: "regulation of defense response to virus by virus" EXACT []
synonym: "viral host defence evasion" NARROW []
synonym: "viral host defense evasion" NARROW []
synonym: "viral regulation of antiviral response" EXACT []
is_obsolete: true
replaced_by: GO:0052031

[Term]
id: GO:0019050
name: obsolete suppression by virus of host apoptotic process
namespace: biological_process
def: "OBSOLETE. A process in which a virus gene product suppresses host apoptosis, leading to a decrease in the frequency, rate or extent of apoptosis in the host cell." [GOC:mtg_apoptosis, ISBN:0781718325]
comment: This term was obsoleted because it is too specific; consider 'symbiont-mediated suppression of host apoptosis' ; GO0033668.
synonym: "inhibition of host caspases by virus" NARROW []
synonym: "negative regulation by virus of host apoptosis" EXACT []
synonym: "negative regulation of apoptosis by virus" EXACT []
synonym: "suppression by virus of host apoptosis" EXACT []
synonym: "suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process" NARROW []
synonym: "suppression of apoptosis in host by virus" EXACT []
is_obsolete: true
replaced_by: GO:0033668

[Term]
id: GO:0019051
name: obsolete induction by virus of host apoptotic process
namespace: biological_process
def: "OBSOLETE. A process in which a viral gene product activates host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell." [GOC:dph, GOC:mtg_apoptosis]
comment: This term was obsoleted because it is too specific; consider symbiont-mediated activation of host apoptosis ; GO:0052151.
synonym: "activation by virus of host apoptosis" EXACT []
synonym: "activation by virus of host apoptotic programmed cell death" EXACT []
synonym: "activation of apoptosis in host by virus" EXACT []
synonym: "activation of host caspases by virus" NARROW []
synonym: "induction by virus of host apoptosis" NARROW []
synonym: "induction by virus of host apoptotic programmed cell death" EXACT []
synonym: "induction by virus of host caspase activity" NARROW []
synonym: "induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process" NARROW []
synonym: "induction of apoptosis in host by virus" EXACT []
synonym: "positive regulation of apoptosis by virus" NARROW []
synonym: "positive regulation of apoptotic process by virus" EXACT []
is_obsolete: true
replaced_by: GO:0052151

[Term]
id: GO:0019054
name: obsolete modulation by virus of host cellular process
namespace: biological_process
def: "OBSOLETE. The process in which a virus effects a change in the processes and activities of its host organism." [GOC:jl]
comment: This term has been replaced by the more general symbiont-mediated perturbation of host cellular process ; GO:0044068.
synonym: "modification by virus of host cellular process" EXACT []
synonym: "modulation by virus of host process" BROAD []
synonym: "modulation of cellular process in host by virus" RELATED []
synonym: "regulation by virus of host cellular process" EXACT []
synonym: "regulation of cellular process in host by virus" EXACT []
synonym: "regulation of host cellular process by virus" EXACT []
synonym: "viral host cell process manipulation" EXACT []
is_obsolete: true
replaced_by: GO:0044068

[Term]
id: GO:0019055
name: obsolete perturbation by virus of host cell cycle regulation
namespace: biological_process
def: "OBSOLETE. Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325]
comment: This term was obsoleted because it represents the same process as symbiont-mediated perturbation of host cell cycle progression ; GO:0044071.
synonym: "modification by virus of host cell cycle regulation" EXACT []
synonym: "viral perturbation of cell cycle regulation" EXACT []
is_obsolete: true
replaced_by: GO:0044071

[Term]
id: GO:0019056
name: obsolete modulation by virus of host transcription
namespace: biological_process
def: "OBSOLETE. Any process in which a virus modulates the frequency, rate or extent of its host's transcription." [PMID:7799962]
comment: This term was obsoleted because it represents the same process as symbiont-mediated perturbation of host transcription ; GO:0052026.
synonym: "modification of host transcription" EXACT []
synonym: "modulation by virus of host transcription" NARROW []
synonym: "perturbation of host cell transcription" EXACT []
is_obsolete: true
replaced_by: GO:0052026

[Term]
id: GO:0019057
name: symbiont-mediated perturbation of host translation
namespace: biological_process
def: "A process in which a symbiont alters or subverts translation of mRNA into protein in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0781718325]
synonym: "host cell protein synthesis shutoff" BROAD []
synonym: "modification by virus of host cell mRNA translation" NARROW []
synonym: "modulation by virus of host translation" NARROW []
synonym: "modulation of host translation by virus" NARROW [GOC:bf]
synonym: "regulation of host mRNA translation" EXACT []
synonym: "regulation of host translation" EXACT []
synonym: "viral perturbation of host cell mRNA translation" NARROW []
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0019058
name: viral life cycle
namespace: biological_process
alt_id: GO:0019067
def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]
subset: goslim_virus
synonym: "lytic viral life cycle" RELATED []
synonym: "viral assembly, maturation, egress, and release" NARROW [GOC:bf, GOC:jl]
synonym: "viral infectious cycle" RELATED [GOC:bf, GOC:jl]
synonym: "viral replication" RELATED [GOC:bf, GOC:jl]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0019059
name: obsolete initiation of viral infection
namespace: biological_process
def: "OBSOLETE. The set of processes involved in the start of virus infection of cells." [ISBN:0781702534]
comment: This term was made obsolete because it is ambiguous, and more specific terms have been created.
synonym: "initiation of viral infection" EXACT []
is_obsolete: true
consider: GO:0046718

[Term]
id: GO:0019060
name: intracellular transport of viral protein in host cell
namespace: biological_process
alt_id: GO:0046742
alt_id: GO:0046743
alt_id: GO:0046801
def: "The directed movement of a viral protein within the host cell." [GOC:ai, ISBN:0781702534, ISBN:0781718325, PMID:11581394, PMID:9188566]
comment: This term is for annotation of proteins responsible for the movement of individual viral proteins, rather than the whole viral particle.
synonym: "cytoplasmic viral capsid transport" NARROW []
synonym: "intracellular transport of viral capsid in host cell" NARROW []
synonym: "intracellular transport of viral capsid protein in host cell" NARROW []
synonym: "intracellular transport of viral proteins in host cell" EXACT []
synonym: "intracellular viral capsid transport" NARROW []
synonym: "intracellular viral protein transport" EXACT []
synonym: "nuclear viral capsid transport" NARROW []
synonym: "viral capsid transport in host cell cytoplasm" NARROW []
synonym: "viral capsid transport in host cell nucleus" NARROW []
is_a: GO:0030581 ! symbiont intracellular protein transport in host
relationship: part_of GO:0046719 ! regulation by virus of viral protein levels in host cell

[Term]
id: GO:0019061
name: uncoating of virus
namespace: biological_process
def: "The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome." [GOC:plm, ISBN:0781702534, PMID:8162442]
synonym: "viral uncoating" EXACT [PMID:8162442]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0019062
name: virion attachment to host cell
namespace: biological_process
def: "The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956]
subset: goslim_virus
synonym: "viral absorption" EXACT []
synonym: "viral attachment to host cell" RELATED [GOC:bf, GOC:jl]
synonym: "virion attachment to host cell surface receptor" NARROW []
xref: VZ:956 "Viral attachment to host cell"
is_a: GO:0044650 ! adhesion of symbiont to host cell
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019064
name: fusion of virus membrane with host plasma membrane
namespace: biological_process
alt_id: GO:0075706
def: "Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm." [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral envelope fusion" BROAD []
synonym: "viral envelope fusion with host cell membrane" EXACT []
synonym: "viral envelope fusion with host membrane" EXACT []
synonym: "viral envelope fusion with host plasma membrane" EXACT []
synonym: "viral penetration via membrane fusion" BROAD []
synonym: "viral-cell fusion molecule activity" RELATED []
xref: VZ:987 "Fusion of virus membrane with host cell membrane"
is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell
is_a: GO:0061025 ! membrane fusion

[Term]
id: GO:0019065
name: receptor-mediated endocytosis of virus by host cell
namespace: biological_process
def: "Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell." [GOC:bf, GOC:jl, ISBN:0781702534]
synonym: "receptor mediated endocytosis by host of virus particle" EXACT []
synonym: "receptor mediated endocytosis of virus by host" EXACT []
synonym: "receptor mediated endocytosis of virus particle by host" EXACT []
synonym: "receptor-mediated endocytosis of virus by host" EXACT []
synonym: "viral entry into host cell via receptor-mediated endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral receptor mediated endocytosis" EXACT []
synonym: "virus receptor-mediated endocytosis by host" EXACT []
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0075509 ! endocytosis involved in viral entry into host cell
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0019066
name: obsolete translocation of virus into host cell
namespace: biological_process
def: "OBSOLETE. The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534]
comment: This term was made obsolete because it is ambiguous, and more specific terms have been created.
synonym: "translocation of virus into host cell" EXACT []
synonym: "viral translocation" EXACT []
is_obsolete: true
replaced_by: GO:0046718

[Term]
id: GO:0019068
name: virion assembly
namespace: biological_process
alt_id: GO:0042963
def: "A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336]
subset: goslim_virus
synonym: "bacteriophage assembly" NARROW [GOC:bm]
synonym: "phage assembly" NARROW [GOC:bm]
synonym: "viral assembly" EXACT []
synonym: "viral particle assembly" EXACT []
synonym: "virion assembly and maintenance" EXACT [GOC:bf, GOC:jl]
synonym: "virion organization" EXACT [GOC:bf, GOC:jl]
synonym: "virus assembly" EXACT [GOC:dph, GOC:tb]
synonym: "virus particle assembly" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019069
name: viral capsid assembly
namespace: biological_process
def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534, PMID:22615368]
xref: VZ:1950
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019070
name: viral genome maturation
namespace: biological_process
def: "The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes." [GOC:pk, PMID:21490093]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019071
name: obsolete viral DNA cleavage involved in viral genome maturation
namespace: biological_process
def: "OBSOLETE. The cleavage of viral DNA into singular functional units." [ISBN:0121585336]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0019072
name: viral genome packaging
namespace: biological_process
def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336]
subset: goslim_virus
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019073
name: viral DNA genome packaging
namespace: biological_process
def: "The packing of viral DNA into a capsid." [ISBN:0781702534]
is_a: GO:0019072 ! viral genome packaging

[Term]
id: GO:0019074
name: viral RNA genome packaging
namespace: biological_process
def: "The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid." [ISBN:0781718325]
is_a: GO:0019072 ! viral genome packaging

[Term]
id: GO:0019075
name: virus maturation
namespace: biological_process
def: "The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release." [ISBN:0781718325]
synonym: "bacteriophage maturation" NARROW [PMID:22308333]
synonym: "viral maturation" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019076
name: viral release from host cell
namespace: biological_process
def: "The dissemination of mature viral particles from a host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl]
synonym: "release of virus from host" EXACT []
synonym: "viral exit" EXACT []
synonym: "viral release" EXACT []
synonym: "viral shedding" EXACT []
synonym: "virus exit from host cell" EXACT [GOC:bf, GOC:jl]
xref: VZ:1076 "Virus exit from host cell"
is_a: GO:0016032 ! viral process
is_a: GO:0035891 ! exit from host cell
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019078
name: obsolete lytic viral budding
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic viral budding" EXACT []
is_obsolete: true

[Term]
id: GO:0019079
name: viral genome replication
namespace: biological_process
def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534]
synonym: "sigma virus replication" NARROW []
synonym: "viral replication" BROAD []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019080
name: viral gene expression
namespace: biological_process
def: "A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation." [GOC:bf, GOC:jl, ISBN:0121585336]
subset: goslim_virus
synonym: "viral genome expression" EXACT [GOC:jl]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0019081
name: viral translation
namespace: biological_process
def: "A process by which viral mRNA is translated into viral protein, using the host cellular machinery." [GOC:bf, GOC:jl, ISBN:0781702534]
synonym: "viral protein anabolism" EXACT []
synonym: "viral protein biosynthesis" EXACT []
synonym: "viral protein biosynthetic process" EXACT [ISBN:0781702534]
synonym: "viral protein formation" EXACT []
synonym: "viral protein synthesis" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019080 ! viral gene expression

[Term]
id: GO:0019082
name: viral protein processing
namespace: biological_process
def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein." [GOC:bf, GOC:jl, ISBN:0781702534]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019080 ! viral gene expression

[Term]
id: GO:0019083
name: viral transcription
namespace: biological_process
def: "The process by which a viral genome, or part of a viral genome, is transcribed within the host cell." [GOC:jl, ISBN:0781702534]
subset: goslim_virus
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019080 ! viral gene expression

[Term]
id: GO:0019084
name: middle viral transcription
namespace: biological_process
def: "The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication." [GOC:bf, GOC:jl]
synonym: "(delayed) early viral mRNA transcription" RELATED [GOC:jh2]
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019085
name: early viral transcription
namespace: biological_process
def: "The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell." [GOC:bf, GOC:jh2, GOC:jl]
synonym: "immediate early viral mRNA transcription" RELATED []
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019086
name: late viral transcription
namespace: biological_process
def: "The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins." [GOC:bf, GOC:jh2, GOC:jl]
synonym: "late viral mRNA transcription" RELATED []
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019087
name: symbiont-mediated transformation of host cell
namespace: biological_process
alt_id: GO:0019088
alt_id: GO:0020021
def: "A symbiont-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication. Usually mediated by viruses." [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315]
synonym: "host cell immortalization" EXACT []
synonym: "host cell transformation" EXACT []
synonym: "immortalization of host cell" EXACT []
synonym: "immortalization of host cell by virus" RELATED []
synonym: "transformation of host cell" EXACT []
synonym: "transformation of host cell by virus" EXACT []
synonym: "viral immortalization" EXACT []
synonym: "viral transformation" EXACT []
synonym: "viral transformation of host cell" EXACT []
synonym: "virus-mediated transformation of host cell" RELATED []
xref: Wikipedia:Viral_transformation
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0019089
name: obsolete transmission of virus
namespace: biological_process
def: "OBSOLETE. The transfer of virions in order to create new infection." [ISBN:0781702534]
comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a virus.
synonym: "viral transmission" EXACT []
is_obsolete: true

[Term]
id: GO:0019090
name: mitochondrial rRNA export from mitochondrion
namespace: biological_process
def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai, PMID:28115039]
synonym: "export of mitochondrial rRNA" BROAD []
synonym: "mitochondrial rRNA export" EXACT []
synonym: "mitochondrial rRNA export from mitochondria" EXACT []
synonym: "mitochondrial rRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial rRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial rRNA, mitochondrial export" EXACT []
is_a: GO:0051029 ! rRNA transport
is_a: GO:0170037 ! export from the mitochondrion

[Term]
id: GO:0019091
name: mitochondrial lrRNA export from mitochondrion
namespace: biological_process
def: "The process in which a lrRNA, large subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai]
synonym: "export of mitochondrial lrRNA" BROAD []
synonym: "mitochondrial lrRNA export" EXACT []
synonym: "mitochondrial lrRNA export from mitochondria" EXACT []
synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial lrRNA, mitochondrial export" EXACT []
is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion

[Term]
id: GO:0019092
name: mitochondrial srRNA export from mitochondrion
namespace: biological_process
def: "The process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai]
synonym: "export of mitochondrial srRNA" BROAD []
synonym: "mitochondrial srRNA export" EXACT []
synonym: "mitochondrial srRNA export from mitochondria" EXACT []
synonym: "mitochondrial srRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial srRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial srRNA, mitochondrial export" EXACT []
is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion

[Term]
id: GO:0019093
name: mitochondrial RNA localization
namespace: biological_process
def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT []
synonym: "mitochondrial RNA localisation" EXACT [GOC:mah]
synonym: "mtRNA localization" EXACT []
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:0019094
name: pole plasm mRNA localization
namespace: biological_process
alt_id: GO:0048120
def: "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT []
synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT []
synonym: "oocyte pole plasm mRNA localization" EXACT []
synonym: "pole granule RNA localization" BROAD []
synonym: "pole plasm mRNA localisation" EXACT [GOC:mah]
is_a: GO:0007316 ! pole plasm RNA localization
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification

[Term]
id: GO:0019095
name: pole plasm mitochondrial rRNA localization
namespace: biological_process
alt_id: GO:0048117
def: "Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT []
synonym: "pole plasm mitochondrial rRNA localisation" EXACT [GOC:mah]
is_a: GO:0007316 ! pole plasm RNA localization
is_a: GO:0019093 ! mitochondrial RNA localization

[Term]
id: GO:0019096
name: pole plasm mitochondrial lrRNA localization
namespace: biological_process
alt_id: GO:0048118
def: "Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT []
synonym: "pole plasm mitochondrial lrRNA localisation" EXACT [GOC:mah]
is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization

[Term]
id: GO:0019097
name: pole plasm mitochondrial srRNA localization
namespace: biological_process
alt_id: GO:0048119
def: "Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT []
synonym: "pole plasm mitochondrial srRNA localisation" EXACT [GOC:mah]
is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization

[Term]
id: GO:0019098
name: reproductive behavior
namespace: biological_process
alt_id: GO:0033057
alt_id: GO:0044704
alt_id: GO:0044705
def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr]
synonym: "multi-organism reproductive behavior" NARROW []
synonym: "multicellular organism reproductive behavior" NARROW []
synonym: "reproductive behavior in a multicellular organism" EXACT []
synonym: "reproductive behaviour" EXACT []
synonym: "single-organism reproductive behavior" RELATED []
is_a: GO:0007610 ! behavior
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0019099
name: female germ-line sex determination
namespace: biological_process
alt_id: GO:0007544
def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah]
synonym: "sex determination, female germ-line determination" EXACT []
is_a: GO:0007542 ! primary sex determination, germ-line
is_a: GO:0018992 ! germ-line sex determination
is_a: GO:0030237 ! female sex determination

[Term]
id: GO:0019100
name: male germ-line sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah]
is_a: GO:0007542 ! primary sex determination, germ-line
is_a: GO:0018992 ! germ-line sex determination
is_a: GO:0030238 ! male sex determination

[Term]
id: GO:0019101
name: female somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah]
is_a: GO:0018993 ! somatic sex determination
is_a: GO:0030237 ! female sex determination

[Term]
id: GO:0019102
name: male somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah]
is_a: GO:0018993 ! somatic sex determination
is_a: GO:0030238 ! male sex determination

[Term]
id: GO:0019103
name: pyrimidine nucleotide binding
namespace: molecular_function
def: "Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0019104
name: DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0008578
def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
synonym: "DNA glycosylase activity" EXACT []
synonym: "endonuclease VIII activity" RELATED []
xref: Reactome:R-HSA-110218 "Cleavage of uracil by TDG glycosylase"
xref: Reactome:R-HSA-110219 "Cleavage of thymine by TDG glycosylase"
xref: Reactome:R-HSA-110231 "Cleavage of uracil by MBD4 glycosylase"
xref: Reactome:R-HSA-110232 "Cleavage of thymine by MBD4 glycosylase"
xref: Reactome:R-HSA-110234 "Cleavage of ethenocytosine by TDG glycosylase"
xref: Reactome:R-HSA-110246 "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH"
xref: Reactome:R-HSA-110248 "Cleavage of 3-methyladenine by MPG glycosylase"
xref: Reactome:R-HSA-110250 "Cleavage of ethenoadenine by MPG glycosylase"
xref: Reactome:R-HSA-110251 "Cleavage of hypoxanthine by MPG glycosylase"
xref: Reactome:R-HSA-5220959 "TDG excises 5-formylcytosine"
xref: Reactome:R-HSA-5221061 "TDG excises 5-carboxylcytosine"
xref: Reactome:R-HSA-5649658 "NEIL1 cleaves DHU from damaged DNA"
xref: Reactome:R-HSA-5649664 "NEIL1 cleaves FapyG from damaged DNA"
xref: Reactome:R-HSA-5649673 "NEIL1 cleaves FapyA from damaged DNA"
xref: Reactome:R-HSA-5649681 "NEIL2 cleaves 5-OHU from damaged DNA"
xref: Reactome:R-HSA-9629149 "NEIL1 cleaves thymine glycol from damaged DNA"
xref: Reactome:R-HSA-9629216 "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA"
xref: Reactome:R-HSA-9629470 "NEIL3 cleaves 5-guanidinohydantoin"
xref: Reactome:R-HSA-9629483 "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA"
xref: Reactome:R-HSA-9629492 "NEIL3 cleaves spiroiminodihydantoin"
xref: Reactome:R-HSA-9629497 "NEIL3 cleaves thymine glycol from telomeric DNA"
xref: Reactome:R-HSA-9629499 "NEIL3 cleaves thymine glycol"
xref: Reactome:R-HSA-9635996 "NEIL3 resolves psoralen-induced ICLs"
xref: Reactome:R-HSA-9636008 "NEIL3 resolves abasic site-induced ICLs"
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0019105
name: obsolete N-palmitoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
comment: This term has been obsoleted because it represents an unnecessary grouping class and is not consistent with the ontology structure.
is_obsolete: true
consider: GO:0016410

[Term]
id: GO:0019107
name: myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai]
xref: Reactome:R-HSA-141367 "Myristoylation of tBID by NMT1"
xref: Reactome:R-HSA-162914 "Myristoylation of Nef"
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0019108
name: aryl-aldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29]
synonym: "aryl-aldehyde dehydrogenase (NAD) activity" EXACT []
synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.29]
xref: EC:1.2.1.29
xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:11804
xref: UM-BBD_reactionID:r0394
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0019111
name: obsolete phenanthrol sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [GOC:curators]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
synonym: "phenanthrol sulphotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0019112
name: phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai]
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0019113
name: limonene monooxygenase activity
namespace: molecular_function
def: "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene." [GOC:mah]
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0019114
name: obsolete catechol dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: catechol + O2 = a muconate." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true
consider: GO:0018576
consider: GO:0018577

[Term]
id: GO:0019115
name: benzaldehyde dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [GOC:curators]
is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0019116
name: hydroxy-nicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide." [GOC:jl, PMID:16095622]
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0019117
name: obsolete dihydroxyfluorene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid." [GOC:mah]
comment: This term was obsoleted because the substrate is not a natural product.
is_obsolete: true

[Term]
id: GO:0019118
name: phenanthrene-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536]
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0019119
name: phenanthrene-9,10-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560]
is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity

[Term]
id: GO:0019120
name: hydrolase activity, acting on acid halide bonds, in C-halide compounds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [EC:3.8.1.-]
xref: EC:3.8.1.-
is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds

[Term]
id: GO:0019121
name: obsolete peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine
namespace: biological_process
def: "OBSOLETE. The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019122
name: peptidyl-D-alanine racemization
namespace: biological_process
def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191]
comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'.
subset: gocheck_do_not_annotate
synonym: "alanine racemization" BROAD []
xref: RESID:AA0191
is_a: GO:0018085 ! peptidyl-L-amino acid racemization
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0019123
name: obsolete peptidyl-methionine racemization
namespace: biological_process
alt_id: GO:0018087
alt_id: GO:0018369
def: "OBSOLETE. The racemization of peptidyl-methionine." [RESID:AA0193]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019124
name: obsolete peptidyl-isoleucine racemization
namespace: biological_process
alt_id: GO:0018088
alt_id: GO:0018370
def: "OBSOLETE. The racemization of peptidyl-isoleucine." [RESID:AA0192]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019125
name: obsolete peptidyl-phenylalanine racemization
namespace: biological_process
alt_id: GO:0018089
alt_id: GO:0018371
def: "OBSOLETE. The racemization of peptidyl-phenylalanine." [RESID:AA0194]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019126
name: obsolete peptidyl-serine racemization
namespace: biological_process
alt_id: GO:0018090
alt_id: GO:0018372
def: "OBSOLETE. The racemization of peptidyl-serine." [RESID:AA0195]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019128
name: obsolete peptidyl-tryptophan racemization
namespace: biological_process
alt_id: GO:0018092
alt_id: GO:0018374
def: "OBSOLETE. The racemization of peptidyl-tryptophan." [RESID:AA0198]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019129
name: obsolete peptidyl-leucine racemization
namespace: biological_process
alt_id: GO:0018093
alt_id: GO:0018375
def: "OBSOLETE. The racemization of peptidyl-leucine." [RESID:AA0197]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019131
name: obsolete tripeptidyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl-peptidase I activity" EXACT []
is_obsolete: true
replaced_by: GO:0008240

[Term]
id: GO:0019132
name: obsolete C-terminal processing peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "C-terminal processing peptidase activity" EXACT []
synonym: "CtpA gene product (Synechocystis sp.)" RELATED []
synonym: "photosystem II D1 protein processing peptidase" NARROW []
synonym: "protease Re" RELATED []
synonym: "tail-specific protease activity" RELATED []
synonym: "Tsp protease" NARROW []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0019133
name: choline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7]
synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" RELATED [EC:1.14.15.7]
xref: EC:1.14.15.7
xref: MetaCyc:RXN1F-357
xref: RHEA:17769
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0019134
name: glucosamine-1-phosphate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H+." [EC:2.3.1.157, RHEA:13725]
synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" RELATED [EC:2.3.1.157]
synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" RELATED [EC:2.3.1.157]
xref: EC:2.3.1.157
xref: KEGG_REACTION:R05332
xref: MetaCyc:2.3.1.157-RXN
xref: RHEA:13725
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0019135
name: deoxyhypusine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29]
synonym: "deoxyhypusine dioxygenase activity" RELATED [EC:1.14.99.29]
synonym: "deoxyhypusine hydroxylase activity" EXACT []
synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.99.29]
synonym: "DOHH activity" RELATED [EC:1.14.99.29]
xref: EC:1.14.99.29
xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A"
xref: RHEA:14101
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0019136
name: deoxynucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]
synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.145]
synonym: "D. melanogaster deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "Dm-dNK" RELATED [EC:2.7.1.145]
synonym: "ms-dNK" RELATED [EC:2.7.1.145]
synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145]
synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145]
xref: EC:2.7.1.145
xref: MetaCyc:2.7.1.145-RXN
xref: Reactome:R-HSA-74207 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)"
xref: RHEA:12140
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0019137
name: thioglucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147]
synonym: "myrosinase activity" EXACT []
synonym: "sinigrase activity" EXACT []
synonym: "sinigrinase activity" EXACT []
synonym: "thioglucoside glucohydrolase activity" EXACT []
xref: EC:3.2.1.147
xref: MetaCyc:RXN-9946
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0019139
name: cytokinin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0046420
def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" RELATED [EC:1.5.99.12]
synonym: "cytokinin oxidase activity" RELATED []
synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" RELATED [EC:1.5.99.12]
synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" RELATED [EC:1.5.99.12]
xref: EC:1.5.99.12
xref: MetaCyc:1.5.99.12-RXN
xref: RHEA:13625
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0019140
name: inositol 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64]
synonym: "ATP:myo-inositol 1-phosphotransferase activity" RELATED [EC:2.7.1.64]
synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64]
synonym: "inositol-1-kinase (phosphorylating)" RELATED [EC:2.7.1.64]
synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64]
synonym: "myo-inositol 3-kinase activity" EXACT []
synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64]
xref: EC:2.7.1.64
xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN
xref: RHEA:21804
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0019141
name: 2-dehydropantolactone reductase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214]
synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" RELATED [EC:1.1.1.214]
synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT []
synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214]
synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214]
synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214]
xref: EC:1.1.1.214
is_a: GO:0036441 ! 2-dehydropantolactone reductase activity

[Term]
id: GO:0019142
name: 2-hydroxyglutarate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H+." [RHEA:19185]
synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" RELATED [EC:2.3.3.11]
synonym: "2-hydroxyglutaratic synthetase activity" RELATED [EC:2.3.3.11]
synonym: "2-hydroxyglutaric synthetase activity" RELATED [EC:2.3.3.11]
synonym: "alpha-hydroxyglutarate synthase activity" RELATED [EC:2.3.3.11]
synonym: "hydroxyglutarate synthase activity" RELATED [EC:2.3.3.11]
synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" RELATED [EC:2.3.3.11]
xref: EC:2.3.3.11
xref: KEGG_REACTION:R00932
xref: MetaCyc:HYDGLUTSYN-RXN
xref: RHEA:19185
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0019143
name: 3-deoxy-manno-octulosonate-8-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45, RHEA:11500]
synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" RELATED [EC:3.1.3.45]
xref: EC:3.1.3.45
xref: KEGG_REACTION:R03350
xref: MetaCyc:KDO-8PPHOSPHAT-RXN
xref: RHEA:11500
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019144
name: ADP-sugar diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21]
synonym: "adenosine diphosphosugar pyrophosphatase activity" RELATED [EC:3.6.1.21]
synonym: "ADP-sugar pyrophosphatase activity" RELATED [EC:3.6.1.21]
synonym: "ADP-sugar sugarphosphohydrolase activity" RELATED [EC:3.6.1.21]
synonym: "ADPsugar pyrophosphatase activity" RELATED [EC:3.6.1.21]
synonym: "nucleoside diphosphate-sugar hydrolase activity" BROAD [GOC:vw]
xref: EC:3.6.1.21
xref: MetaCyc:ADPSUGPPHOSPHAT-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0019145
name: aminobutyraldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19]
synonym: "4-aminobutanal dehydrogenase activity" RELATED [EC:1.2.1.19]
synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" RELATED [EC:1.2.1.19]
synonym: "4-aminobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.19]
synonym: "ABAL dehydrogenase activity" RELATED [EC:1.2.1.19]
synonym: "gamma-aminobutyraldehyde dehydroganase activity" RELATED [EC:1.2.1.19]
xref: EC:1.2.1.19
xref: MetaCyc:AMINOBUTDEHYDROG-RXN
xref: RHEA:19105
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0019146
name: arabinose-5-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H+." [EC:5.3.1.13, RHEA:23104]
synonym: "arabinose phosphate isomerase activity" RELATED [EC:5.3.1.13]
synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.13]
synonym: "D-arabinose-5-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.13]
synonym: "phosphoarabinoisomerase activity" RELATED [EC:5.3.1.13]
xref: EC:5.3.1.13
xref: KEGG_REACTION:R01530
xref: MetaCyc:DARAB5PISOM-RXN
xref: RHEA:23104
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0019147
name: (R)-aminopropanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + H+ + NADH." [EC:1.1.1.75, RHEA:16517]
synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.75]
synonym: "1-aminopropan-2-ol-dehydrogenase activity" RELATED [EC:1.1.1.75]
synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" RELATED [EC:1.1.1.75]
synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" RELATED [EC:1.1.1.75]
synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" RELATED [EC:1.1.1.75]
synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.75]
synonym: "L-aminopropanol dehydrogenase activity" EXACT []
xref: EC:1.1.1.75
xref: KEGG_REACTION:R03759
xref: MetaCyc:AMINOPROPDEHYDROG-RXN
xref: RHEA:16517
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019148
name: D-cysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15]
synonym: "D-cysteine lyase activity" RELATED [EC:4.4.1.15]
synonym: "D-cysteine sulfide-lyase (deaminating)" RELATED [EC:4.4.1.15]
synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.4.1.15]
xref: EC:4.4.1.15
xref: MetaCyc:DCYSDESULF-RXN
xref: RHEA:11268
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0019149
name: 3-chloro-D-alanine dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2]
synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" RELATED [EC:4.5.1.2]
synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.5.1.2]
synonym: "beta-chloro-D-alanine dehydrochlorinase activity" RELATED [EC:4.5.1.2]
xref: EC:4.5.1.2
xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN
xref: RHEA:18873
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0019150
name: D-ribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47]
synonym: "ATP:D-ribulose 5-phosphotransferase activity" RELATED [EC:2.7.1.47]
synonym: "D-ribulokinase (phosphorylating)" RELATED [EC:2.7.1.47]
xref: EC:2.7.1.47
xref: MetaCyc:D-RIBULOKIN-RXN
xref: RHEA:17601
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0019151
name: galactose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48]
synonym: "beta-galactose dehydrogenase activity" RELATED [EC:1.1.1.48]
synonym: "D-galactose 1-dehydrogenase activity" EXACT []
synonym: "D-galactose dehydrogenase activity" RELATED [EC:1.1.1.48]
synonym: "D-galactose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.48]
synonym: "NAD-dependent D-galactose dehydrogenase activity" RELATED [EC:1.1.1.48]
xref: EC:1.1.1.48
xref: MetaCyc:GALACTODEHYDROG-RXN
xref: RHEA:21296
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019152
name: acetoin dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. This reaction is catalyzed in the reverse direction." [MetaCyc:ACETOINDEHYDROG-RXN]
synonym: "diacetyl reductase activity" EXACT []
xref: KEGG_REACTION:R02343
xref: MetaCyc:ACETOINDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019153
name: protein-disulfide reductase (glutathione) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol." [RHEA:21064]
synonym: "glutaredoxin reductase" RELATED []
synonym: "glutathione-insulin transhydrogenase activity" NARROW []
synonym: "insulin reductase activity" NARROW [EC:1.8.4.2]
synonym: "protein disulfide reductase (glutathione)" RELATED [EC:1.8.4.2]
synonym: "protein disulfide transhydrogenase activity" RELATED [EC:1.8.4.2]
synonym: "protein-disulphide reductase (glutathione) activity" EXACT []
xref: EC:1.8.4.2
xref: MetaCyc:PRODISULFREDUCT-RXN
xref: RHEA:21064
is_a: GO:0015035 ! protein-disulfide reductase activity
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0019154
name: glycolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate." [EC:1.1.99.14, RHEA:21264]
synonym: "glycolate oxidoreductase activity" RELATED [EC:1.1.99.14]
synonym: "glycolate:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.99.14]
synonym: "glycolate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.14]
synonym: "glycolic acid dehydrogenase activity" RELATED [EC:1.1.99.14]
xref: EC:1.1.99.14
xref: KEGG_REACTION:R00476
xref: MetaCyc:GLYCOLATEDEHYDRO-RXN
xref: RHEA:21264
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0019155
name: 3-(imidazol-5-yl)lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111]
synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.111]
synonym: "imidazol-5-yl lactate dehydrogenase activity" RELATED [EC:1.1.1.111]
xref: EC:1.1.1.111
xref: MetaCyc:IMILACTDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019156
name: isoamylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68]
synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68]
synonym: "glycogen alpha-1,6-glucanohydrolase activity" RELATED [EC:3.2.1.68]
xref: EC:3.2.1.68
xref: MetaCyc:3.2.1.68-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0019157
name: obsolete malate oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (S)-malate + O2 = H2O2 + oxaloacetate." [GOC:curators]
comment: This term is slated for obsoletion because RHEA indicates there is not enough experimental evidence.
synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT []
synonym: "FAD-dependent malate oxidase activity" EXACT []
synonym: "malic dehydrogenase II" RELATED []
synonym: "malic oxidase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0019158
name: mannokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7]
synonym: "ATP:D-mannose 6-phosphotransferase activity" RELATED [EC:2.7.1.7]
synonym: "D-fructose (D-mannose) kinase activity" RELATED [EC:2.7.1.7]
synonym: "mannokinase (phosphorylating)" RELATED [EC:2.7.1.7]
xref: EC:2.7.1.7
xref: MetaCyc:MANNKIN-RXN
xref: Reactome:R-HSA-9909159 "HK1 phosphorylates Mannose to Man6P"
xref: RHEA:11028
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0019159
name: nicotinamide-nucleotide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42]
synonym: "nicotinamide mononucleotide amidohydrolase activity" RELATED [EC:3.5.1.42]
synonym: "nicotinamide mononucleotide deamidase activity" RELATED [EC:3.5.1.42]
synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" RELATED [EC:3.5.1.42]
synonym: "NMN amidohydrolase" NARROW []
synonym: "NMN deamidase activity" RELATED [EC:3.5.1.42]
xref: EC:3.5.1.42
xref: MetaCyc:NMNAMIDOHYDRO-RXN
xref: RHEA:12400
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019160
name: NMN nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + nicotinamide mononucleotide = D-ribose 5-phosphate + H+ + nicotinamide." [EC:3.2.2.14, RHEA:23140]
synonym: "nicotinamide mononucleotidase activity" RELATED [EC:3.2.2.14]
synonym: "nicotinamide mononucleotide nucleosidase activity" RELATED [EC:3.2.2.14]
synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" RELATED [EC:3.2.2.14]
synonym: "NMN glycohydrolase activity" RELATED [EC:3.2.2.14]
synonym: "NMNase activity" RELATED [EC:3.2.2.14]
synonym: "NMNGhase activity" RELATED [EC:3.2.2.14]
xref: EC:3.2.2.14
xref: KEGG_REACTION:R01270
xref: MetaCyc:NMNNUCLEOSID-RXN
xref: RHEA:23140
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0019161
name: diamine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29]
synonym: "amine transaminase activity" RELATED [EC:2.6.1.29]
synonym: "amine-ketoacid transaminase activity" RELATED [EC:2.6.1.29]
synonym: "diamine aminotransferase activity" EXACT []
synonym: "diamine-ketoglutaric transaminase activity" RELATED [EC:2.6.1.29]
synonym: "diamine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.29]
xref: EC:2.6.1.29
xref: MetaCyc:DIAMTRANSAM-RXN
xref: RHEA:18217
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019162
name: pyridoxamine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal." [EC:2.6.1.31, RHEA:10844]
synonym: "pyridoxamine--oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.31]
synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT []
synonym: "pyridoxamine:oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.31]
xref: EC:2.6.1.31
xref: KEGG_REACTION:R01713
xref: MetaCyc:PYROXALTRANSAM-RXN
xref: RHEA:10844
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019163
name: pyridoxamine-phosphate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54]
synonym: "pyridoxamine 5'-phosphate transaminase activity" RELATED [EC:2.6.1.54]
synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.54]
synonym: "pyridoxamine phosphate aminotransferase activity" RELATED [EC:2.6.1.54]
synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" RELATED [EC:2.6.1.54]
synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT []
xref: EC:2.6.1.54
xref: MetaCyc:PYRDAMPTRANS-RXN
xref: RHEA:15877
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019164
name: pyruvate synthase activity
namespace: molecular_function
alt_id: GO:0018696
def: "Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+." [KEGG_REACTION:R01196]
synonym: "PFOR" EXACT []
synonym: "pyruvate oxidoreductase activity" RELATED [EC:1.2.7.1]
synonym: "pyruvate synthetase activity" RELATED [EC:1.2.7.1]
synonym: "pyruvate-ferredoxin reductase activity" EXACT []
synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.7.1]
synonym: "pyruvate:ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.1]
synonym: "pyruvic-ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.1]
xref: EC:1.2.7.1
xref: KEGG_REACTION:R01196
xref: MetaCyc:PYRUFLAVREDUCT-RXN
xref: RHEA:12765
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0019165
name: thiamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate." [EC:2.7.1.89, RHEA:12012]
synonym: "ATP:thiamin phosphotransferase activity" RELATED [EC:2.7.1.89]
synonym: "ATP:thiamine phosphotransferase activity" RELATED [EC:2.7.1.89]
synonym: "thiamin kinase (phosphorylating)" RELATED [EC:2.7.1.89]
synonym: "thiamin kinase activity" RELATED [EC:2.7.1.89]
synonym: "thiamin phosphokinase activity" RELATED [EC:2.7.1.89]
xref: EC:2.7.1.89
xref: KEGG_REACTION:R02134
xref: MetaCyc:THIKIN-RXN
xref: RHEA:12012
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0019166
name: trans-2-enoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38]
synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" RELATED [EC:1.3.1.38]
synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" RELATED [EC:1.3.1.38]
synonym: "reductase, trans-enoyl coenzyme A" RELATED [EC:1.3.1.38]
xref: EC:1.3.1.38
xref: MetaCyc:TRANSENOYLCOARED-RXN
xref: Reactome:R-HSA-6786720 "DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA"
xref: Reactome:R-HSA-6809810 "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA"
xref: Reactome:R-HSA-8952873 "MECR dimer reduces tdec2-CoA to DEC-CoA"
xref: RHEA:33763
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019168
name: 2-octaprenylphenol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN]
xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN
xref: RHEA:27790
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0019170
name: methylglyoxal reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78]
synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.78]
synonym: "D-lactaldehyde dehydrogenase activity" EXACT []
synonym: "methylglyoxal reductase (NADH-dependent) activity" EXACT []
synonym: "methylglyoxal reductase activity" EXACT []
xref: EC:1.1.1.78
xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:24528
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019171
name: (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O." [RHEA:13097]
synonym: "(3R)-3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity" RELATED []
synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity" BROAD []
synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT []
xref: EC:4.2.1.59
xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN
xref: RHEA:13097
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0019172
name: glyoxalase III activity
namespace: molecular_function
def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [GOC:mcc, PMID:21696459, PMID:7848303, RHEA:27754]
comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase).
synonym: "(R)-lactate hydro-lyase" EXACT []
synonym: "D-lactate dehydratase" EXACT []
synonym: "glutathione-independent glyoxalase activity" RELATED []
xref: EC:4.2.1.130
xref: MetaCyc:GLYOXIII-RXN
xref: RHEA:27754
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0019174
name: tetrahydrothiophene 1-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN]
xref: MetaCyc:THTOREDUCT-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0019176
name: dihydroneopterin monophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN]
synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT []
xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN
xref: RHEA:25306
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0019177
name: dihydroneopterin triphosphate pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [RHEA:25302]
xref: EC:3.6.1.67
xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN
xref: RHEA:25302
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0019178
name: NADP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [RHEA:28050]
xref: MetaCyc:RXN-5822
xref: RHEA:28050
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019179
name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33]
synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT []
synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.33]
synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.33]
synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.33]
synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" RELATED [EC:2.6.1.33]
synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" RELATED [EC:2.6.1.33]
synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.33]
synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" RELATED [EC:2.6.1.33]
xref: EC:2.6.1.33
xref: MetaCyc:2.6.1.33-RXN
xref: RHEA:19085
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019180
name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose." [EC:2.6.1.59, RHEA:10368]
synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.59]
synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" RELATED [EC:2.6.1.59]
synonym: "dTDP-fucosamine aminotransferase activity" EXACT []
synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.59]
synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" RELATED [EC:2.6.1.59]
xref: EC:2.6.1.59
xref: KEGG_REACTION:R04438
xref: MetaCyc:RFFTRANS-RXN
xref: RHEA:10368
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019181
name: halohydrin hydrogen-halide-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide." [PMID:8017917]
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0019182
name: histamine-gated chloride channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane channel that opens when bound to histamine." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity

[Term]
id: GO:0019183
name: histamine-gated chloride channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034707 ! chloride channel complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0019184
name: nonribosomal peptide biosynthetic process
namespace: biological_process
def: "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732]
synonym: "non-ribosomal peptide biosynthesis" EXACT []
synonym: "non-ribosomal peptide biosynthetic process" EXACT []
synonym: "non-ribosomal peptide formation" EXACT []
synonym: "non-ribosomal peptide synthesis" EXACT []
synonym: "nonribosomal peptide anabolism" EXACT []
synonym: "nonribosomal peptide biosynthesis" EXACT []
synonym: "nonribosomal peptide formation" EXACT []
synonym: "nonribosomal peptide synthesis" EXACT []
synonym: "nonribosomal peptide synthetase" RELATED []
is_a: GO:0043043 ! peptide biosynthetic process

[Term]
id: GO:0019185
name: snRNA-activating protein complex
namespace: cellular_component
def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788]
synonym: "SNAPc" EXACT []
is_a: GO:0005667 ! transcription regulator complex

[Term]
id: GO:0019186
name: acyl-CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule." [GOC:mah]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0019187
name: beta-1,4-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage." [GOC:mcc, PMID:8166646]
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0019191
name: cellobiose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019190
def: "Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "cellobiose permease activity" EXACT []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0019194
name: sorbose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019193
def: "Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "sorbose porter activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0019196
name: galactosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019195
def: "Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "galactosamine porter activity" EXACT []
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0019197
name: phosphoenolpyruvate-dependent sugar phosphotransferase complex
namespace: cellular_component
def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0019198
name: transmembrane receptor protein phosphatase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd]
is_a: GO:0004721 ! phosphoprotein phosphatase activity
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0019199
name: transmembrane receptor protein kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah]
xref: Reactome:R-HSA-8983059 "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex"
xref: Reactome:R-HSA-8983063 "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated"
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0019200
name: carbohydrate kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]
xref: Reactome:R-HSA-8931653 "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1"
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019202
name: amino acid kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019203
name: carbohydrate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]
xref: Reactome:R-HSA-3781011 "EPM2A dimer dephosphorylates phosphoglycogen-GYG2"
xref: Reactome:R-HSA-3781018 "EPM2A dimer dephosphorylates phosphoglycogen-GYG1"
xref: Reactome:R-HSA-3791349 "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019204
name: obsolete nucleotide phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah]
comment: This term was defined to cover phosphatase activity against polynucleotides, but had subclasses and annotations for phosphatase activity against free nucleotides.
synonym: "nucleotide phosphatase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0019205
name: nucleobase-containing compound kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
synonym: "nucleobase, nucleoside, nucleotide kinase activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019206
name: nucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai]
xref: Reactome:R-HSA-109671 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)"
xref: Reactome:R-HSA-109759 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]"
xref: Reactome:R-HSA-109903 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]"
xref: Reactome:R-HSA-110137 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP"
xref: Reactome:R-HSA-110138 "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs"
xref: Reactome:R-HSA-73598 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)"
xref: Reactome:R-HSA-73599 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]"
xref: Reactome:R-HSA-73632 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]"
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0019207
name: kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0019208
name: phosphatase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0019209
name: kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0019210
name: kinase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0019211
name: phosphatase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a phosphatase." [GOC:ai]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0019208 ! phosphatase regulator activity

[Term]
id: GO:0019212
name: phosphatase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a phosphatase." [GOC:ai]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0019208 ! phosphatase regulator activity

[Term]
id: GO:0019213
name: deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group from a substrate molecule." [GOC:jl]
subset: goslim_pir
xref: Reactome:R-HSA-5689000 "AADAC deacetylates PHEN"
is_a: GO:0160215 ! deacylase activity

[Term]
id: GO:0019214
name: obsolete surfactant activity
namespace: molecular_function
def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it represents involvement in a process.
synonym: "surfactant activity" EXACT []
is_obsolete: true
consider: GO:0043129

[Term]
id: GO:0019215
name: intermediate filament binding
namespace: molecular_function
def: "Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732]
is_a: GO:0005488 ! binding

[Term]
id: GO:0019216
name: regulation of lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "regulation of lipid metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0019217
name: regulation of fatty acid metabolic process
namespace: biological_process
alt_id: GO:0006632
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
synonym: "regulation of fatty acid metabolism" EXACT []
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0019218
name: regulation of steroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "regulation of steroid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0019219
name: regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0019220
name: regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "regulation of phosphate metabolism" EXACT []
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0019221
name: cytokine-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]
synonym: "cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "cytokine mediated signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0019222
name: regulation of metabolic process
namespace: biological_process
alt_id: GO:0044246
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: goslim_metagenomics
synonym: "regulation of metabolism" EXACT []
synonym: "regulation of multicellular organismal metabolic process" NARROW []
synonym: "regulation of organismal metabolic process" NARROW [GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0008152 ! metabolic process

[Term]
id: GO:0019226
name: transmission of nerve impulse
namespace: biological_process
def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194]
synonym: "conduction of nerve impulse" EXACT [GOC:dph]
synonym: "signal transmission along a neuron" EXACT []
is_a: GO:0050877 ! nervous system process
relationship: part_of GO:0007154 ! cell communication

[Term]
id: GO:0019227
name: neuronal action potential propagation
namespace: biological_process
def: "The propagation of an action potential along an axon, away from the soma." [GOC:isa_complete]
is_a: GO:0050877 ! nervous system process
is_a: GO:0098870 ! action potential propagation
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0019228
name: neuronal action potential
namespace: biological_process
def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001508 ! action potential
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0019229
name: regulation of vasoconstriction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl]
is_a: GO:0097746 ! blood vessel diameter maintenance
is_a: GO:1903522 ! regulation of blood circulation
relationship: regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0019230
name: proprioception
namespace: biological_process
def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [ISBN:072168677X]
xref: Wikipedia:Proprioception
is_a: GO:0007600 ! sensory perception
relationship: part_of GO:0050884 ! neuromuscular process controlling posture

[Term]
id: GO:0019231
name: perception of static position
namespace: biological_process
def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X]
is_a: GO:0019230 ! proprioception

[Term]
id: GO:0019232
name: perception of rate of movement
namespace: biological_process
def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah]
synonym: "kinesthesia" EXACT []
is_a: GO:0019230 ! proprioception

[Term]
id: GO:0019233
name: sensory perception of pain
namespace: biological_process
def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators]
synonym: "nociception" RELATED []
synonym: "perception of physiological pain" NARROW []
xref: Wikipedia:Nociception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0019234
name: sensory perception of fast pain
namespace: biological_process
def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [PMID:38704307]
is_a: GO:0019233 ! sensory perception of pain

[Term]
id: GO:0019235
name: sensory perception of slow pain
namespace: biological_process
def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, PMID:38704307]
is_a: GO:0019233 ! sensory perception of pain

[Term]
id: GO:0019236
name: response to pheromone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]
synonym: "pheromone response" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0019237
name: centromeric DNA binding
namespace: molecular_function
def: "Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [GOC:jl, SO:0000577]
synonym: "centromere binding" EXACT []
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0019238
name: cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah]
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0019239
name: deaminase activity
namespace: molecular_function
def: "Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]
subset: goslim_pir
xref: Reactome:R-HSA-74241 "ADA catalyzes the deamination of (deoxy)adenosine"
xref: Reactome:R-HSA-9014641 "HRSP12 deaminates 2AA to 2OBUTA"
xref: Reactome:R-HSA-9734745 "Defective ADA does not deaminate (deoxy)adenosine"
xref: Reactome:R-HSA-9754964 "ADA deamidates RBV"
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0019240
name: citrulline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]
synonym: "citrulline anabolism" EXACT []
synonym: "citrulline biosynthesis" EXACT []
synonym: "citrulline formation" EXACT []
synonym: "citrulline synthesis" EXACT []
xref: MetaCyc:CITRULBIO-PWY
is_a: GO:0000052 ! citrulline metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0019241
name: citrulline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]
synonym: "citrulline breakdown" EXACT []
synonym: "citrulline catabolism" EXACT []
synonym: "citrulline degradation" EXACT []
xref: MetaCyc:CITRULLINE-DEG-PWY
is_a: GO:0000052 ! citrulline metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019242
name: methylglyoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai]
synonym: "methylglyoxal anabolism" EXACT []
synonym: "methylglyoxal biosynthesis" EXACT []
synonym: "methylglyoxal formation" EXACT []
synonym: "methylglyoxal synthesis" EXACT []
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0019243
name: methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020]
synonym: "D-lactate biosynthesis from methylglyoxal" BROAD []
synonym: "D-lactate biosynthetic process from methylglyoxal" BROAD []
synonym: "glyoxalase system" RELATED []
synonym: "methylglyoxal breakdown to D-lactate" BROAD []
synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT []
synonym: "methylglyoxal degradation to D-lactate" BROAD []
synonym: "methylglyoxal detoxification" RELATED []
xref: MetaCyc:PWY-5386
is_a: GO:0061727 ! methylglyoxal catabolic process to lactate

[Term]
id: GO:0019244
name: lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators]
synonym: "lactate anabolism from pyruvate" EXACT []
synonym: "lactate formation from pyruvate" EXACT []
synonym: "lactate synthesis from pyruvate" EXACT []
synonym: "pyruvate fermentation to lactate" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0019249 ! lactate biosynthetic process

[Term]
id: GO:0019245
name: D(-)-lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators]
synonym: "D(-)-lactate anabolism from pyruvate" EXACT []
synonym: "D(-)-lactate formation from pyruvate" EXACT []
synonym: "D(-)-lactate synthesis from pyruvate" EXACT []
is_a: GO:0019244 ! lactate biosynthetic process from pyruvate

[Term]
id: GO:0019246
name: L(+)-lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate." [GOC:go_curators]
synonym: "L(+)-lactate anabolism from pyruvate" EXACT []
synonym: "L(+)-lactate formation from pyruvate" EXACT []
synonym: "L(+)-lactate synthesis from pyruvate" EXACT []
synonym: "S-lactate biosynthetic process from pyruvate" EXACT []
xref: MetaCyc:PWY-5481
is_a: GO:0019244 ! lactate biosynthetic process from pyruvate

[Term]
id: GO:0019247
name: lactate racemization
namespace: biological_process
def: "Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [GOC:curators, PMID:16166538]
is_a: GO:0006089 ! lactate metabolic process

[Term]
id: GO:0019248
name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:dph, GOC:go_curators, MetaCyc:MGLDLCTANA-PWY]
synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT []
synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT []
synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT []
xref: MetaCyc:MGLDLCTANA-PWY
is_a: GO:0019249 ! lactate biosynthetic process
is_a: GO:0061727 ! methylglyoxal catabolic process to lactate

[Term]
id: GO:0019249
name: lactate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators]
synonym: "lactate anabolism" EXACT []
synonym: "lactate biosynthesis" EXACT []
synonym: "lactate formation" EXACT []
synonym: "lactate synthesis" EXACT []
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0019250
name: aerobic cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators]
synonym: "aerobic cobalamin anabolism" EXACT []
synonym: "aerobic cobalamin biosynthesis" EXACT []
synonym: "aerobic cobalamin formation" EXACT []
synonym: "aerobic cobalamin synthesis" EXACT []
synonym: "aerobic vitamin B12 biosynthesis" EXACT []
synonym: "aerobic vitamin B12 biosynthetic process" EXACT []
synonym: "cobalamin biosynthesis, aerobic" EXACT []
synonym: "cobalamin biosynthetic process, aerobic" EXACT []
synonym: "vitamin B12 biosynthesis, aerobic" EXACT []
synonym: "vitamin B12 biosynthetic process, aerobic" EXACT []
xref: MetaCyc:P381-PWY
is_a: GO:0009236 ! cobalamin biosynthetic process

[Term]
id: GO:0019251
name: anaerobic cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators]
synonym: "anaerobic cobalamin anabolism" EXACT []
synonym: "anaerobic cobalamin biosynthesis" EXACT []
synonym: "anaerobic cobalamin formation" EXACT []
synonym: "anaerobic cobalamin synthesis" EXACT []
synonym: "anaerobic vitamin B12 biosynthesis" EXACT []
synonym: "anaerobic vitamin B12 biosynthetic process" EXACT []
synonym: "cobalamin biosynthesis, anaerobic" EXACT []
synonym: "cobalamin biosynthetic process, anaerobic" EXACT []
synonym: "vitamin B12 biosynthesis, anaerobic" EXACT []
synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT []
xref: MetaCyc:COBALSYN-PWY
is_a: GO:0009236 ! cobalamin biosynthetic process

[Term]
id: GO:0019252
name: starch biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai]
synonym: "starch anabolism" EXACT []
synonym: "starch biosynthesis" EXACT []
synonym: "starch formation" EXACT []
synonym: "starch synthesis" EXACT []
xref: MetaCyc:PWY-622
is_a: GO:0005982 ! starch metabolic process
is_a: GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0019253
name: reductive pentose-phosphate cycle
namespace: biological_process
def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684]
comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'.
synonym: "C3 photosynthesis" NARROW []
synonym: "Calvin cycle" NARROW []
xref: MetaCyc:CALVIN-PWY
is_a: GO:0019685 ! photosynthesis, dark reaction
relationship: part_of GO:0015977 ! carbon fixation

[Term]
id: GO:0019254
name: carnitine metabolic process, CoA-linked
namespace: biological_process
def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators]
synonym: "carnitine metabolism, CoA-linked" EXACT []
xref: MetaCyc:CARNMET-PWY
is_a: GO:0009437 ! carnitine metabolic process

[Term]
id: GO:0019255
name: glucose 1-phosphate metabolic process
namespace: biological_process
alt_id: GO:0006008
def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai]
synonym: "glucose 1-phosphate metabolism" EXACT []
synonym: "glucose 1-phosphate utilization" RELATED [GOC:mah]
xref: MetaCyc:GLUCOSE1PMETAB-PWY
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019256
name: acrylonitrile catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai, PMID:1390687, PMID:3830164]
synonym: "acrylonitrile breakdown" EXACT []
synonym: "acrylonitrile catabolism" EXACT []
synonym: "acrylonitrile degradation" EXACT []
xref: MetaCyc:P344-PWY
xref: UM-BBD_pathwayID:acr
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0050899 ! nitrile catabolic process

[Term]
id: GO:0019257
name: 4-nitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai]
synonym: "4-nitrotoluene metabolism" EXACT []
synonym: "4NT metabolic process" EXACT []
synonym: "4NT metabolism" EXACT []
is_a: GO:0019326 ! nitrotoluene metabolic process

[Term]
id: GO:0019258
name: 4-nitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai]
synonym: "4-nitrotoluene breakdown" EXACT []
synonym: "4-nitrotoluene catabolism" EXACT []
synonym: "4-nitrotoluene degradation" EXACT []
synonym: "4NT catabolic process" EXACT []
synonym: "4NT catabolism" EXACT []
xref: MetaCyc:P421-PWY
is_a: GO:0019257 ! 4-nitrotoluene metabolic process
is_a: GO:0046263 ! nitrotoluene catabolic process

[Term]
id: GO:0019260
name: 1,2-dichloroethane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators]
synonym: "1,2-dichloroethane breakdown" EXACT []
synonym: "1,2-dichloroethane catabolism" EXACT []
synonym: "1,2-dichloroethane degradation" EXACT []
xref: MetaCyc:12DICHLORETHDEG-PWY
is_a: GO:0018899 ! 1,2-dichloroethane metabolic process
is_a: GO:0042206 ! halogenated hydrocarbon catabolic process

[Term]
id: GO:0019261
name: 1,4-dichlorobenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai, PMID:9148781]
synonym: "1,4-dichlorobenzene breakdown" EXACT []
synonym: "1,4-dichlorobenzene catabolism" EXACT []
synonym: "1,4-dichlorobenzene degradation" EXACT []
xref: MetaCyc:14DICHLORBENZDEG-PWY
xref: UM-BBD_pathwayID:dcz
is_a: GO:0009056 ! catabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0019262
name: N-acetylneuraminate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]
synonym: "N-acetylneuraminate breakdown" EXACT []
synonym: "N-acetylneuraminate catabolism" EXACT []
synonym: "N-acetylneuraminate degradation" EXACT []
xref: MetaCyc:P441-PWY
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019263
name: adamantanone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai]
synonym: "adamantanone breakdown" EXACT []
synonym: "adamantanone catabolism" EXACT []
synonym: "adamantanone degradation" EXACT []
xref: MetaCyc:P481-PWY
is_a: GO:0018866 ! adamantanone metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0019264
name: glycine biosynthetic process from serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators]
synonym: "glycine anabolism from serine" EXACT []
synonym: "glycine formation from serine" EXACT []
synonym: "glycine synthesis from serine" EXACT []
xref: MetaCyc:GLYSYN-PWY
is_a: GO:0006545 ! glycine biosynthetic process
is_a: GO:0006563 ! L-serine metabolic process

[Term]
id: GO:0019265
name: glycine biosynthetic process, by transamination of glyoxylate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators]
synonym: "glycine anabolism, by transamination of glyoxylate" EXACT []
synonym: "glycine formation, by transamination of glyoxylate" EXACT []
synonym: "glycine synthesis, by transamination of glyoxylate" EXACT []
is_a: GO:0006545 ! glycine biosynthetic process

[Term]
id: GO:0019266
name: asparagine biosynthetic process from oxaloacetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators]
synonym: "asparagine anabolism from oxaloacetate" EXACT []
synonym: "asparagine formation from oxaloacetate" EXACT []
synonym: "asparagine synthesis from oxaloacetate" EXACT []
xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0019267
name: asparagine biosynthetic process from cysteine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators]
synonym: "asparagine anabolism from cysteine" EXACT []
synonym: "asparagine formation from cysteine" EXACT []
synonym: "asparagine synthesis from cysteine" EXACT []
xref: MetaCyc:ASPSYNII-PWY
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0006534 ! cysteine metabolic process

[Term]
id: GO:0019268
name: obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function.
synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT []
is_obsolete: true
consider: GO:0004353
consider: GO:0006537

[Term]
id: GO:0019269
name: obsolete glutamate biosynthetic process, using glutamate synthase (NADPH)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators]
comment: This term was made obsolete because it refers to a molecular function.
synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT []
is_obsolete: true
consider: GO:0004355
consider: GO:0006537

[Term]
id: GO:0019270
name: aerobactin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
synonym: "aerobactin anabolism" EXACT []
synonym: "aerobactin biosynthesis" EXACT []
synonym: "aerobactin formation" EXACT []
synonym: "aerobactin synthesis" EXACT []
xref: MetaCyc:AEROBACTINSYN-PWY
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0046442 ! aerobactin metabolic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process

[Term]
id: GO:0019271
name: aerobactin transport
namespace: biological_process
def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai, PMID:23192658]
is_a: GO:0006842 ! tricarboxylic acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0019272
name: L-alanine biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators]
synonym: "L-alanine anabolism from pyruvate" EXACT []
synonym: "L-alanine formation from pyruvate" EXACT []
synonym: "L-alanine synthesis from pyruvate" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0042852 ! L-alanine biosynthetic process

[Term]
id: GO:0019273
name: L-alanine biosynthetic process via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators]
synonym: "L-alanine anabolism via ornithine" EXACT []
synonym: "L-alanine formation via ornithine" EXACT []
synonym: "L-alanine synthesis via ornithine" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0042852 ! L-alanine biosynthetic process

[Term]
id: GO:0019276
name: UDP-N-acetylgalactosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-N-acetylgalactosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0019277
name: UDP-N-acetylgalactosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-N-acetylgalactosamine anabolism" EXACT []
synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT []
synonym: "UDP-N-acetylgalactosamine formation" EXACT []
synonym: "UDP-N-acetylgalactosamine synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0019278
name: UDP-N-acetylgalactosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-N-acetylgalactosamine breakdown" EXACT []
synonym: "UDP-N-acetylgalactosamine catabolism" EXACT []
synonym: "UDP-N-acetylgalactosamine degradation" EXACT []
is_a: GO:0009227 ! nucleotide-sugar catabolic process
is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0019279
name: L-methionine biosynthetic process from L-homoserine via cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators]
synonym: "L-methionine anabolism from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from L-homoserine via cystathionine" EXACT [GOC:mah]
xref: MetaCyc:HOMOSER-METSYN-PWY
is_a: GO:0009092 ! homoserine metabolic process
is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0019280
name: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators]
synonym: "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:HSERMETANA-PWY
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0019281
name: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators]
synonym: "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:MET-SAM-PWY
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0019283
name: L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators]
synonym: "L-methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0019284
name: L-methionine salvage from S-adenosylmethionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine." [GOC:go_curators, GOC:vw]
synonym: "L-methionine formation from S-adenosylmethionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from S-adenosylmethionine" EXACT [GOC:mah]
is_a: GO:0071267 ! L-methionine salvage
relationship: part_of GO:0033353 ! S-adenosylmethionine cycle

[Term]
id: GO:0019285
name: glycine betaine biosynthetic process from choline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl]
synonym: "choline oxidation" EXACT [GOC:dph, PMID:23563483]
synonym: "glycine betaine anabolism from choline" EXACT []
synonym: "glycine betaine formation from choline" EXACT []
synonym: "glycine betaine synthesis from choline" EXACT []
synonym: "N-trimethylglycine biosynthesis from choline" EXACT []
synonym: "N-trimethylglycine biosynthetic process from choline" EXACT []
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0031456 ! glycine betaine biosynthetic process

[Term]
id: GO:0019286
name: glycine betaine biosynthetic process from glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators]
synonym: "glycine betaine anabolism from glycine" EXACT []
synonym: "glycine betaine formation from glycine" EXACT []
synonym: "glycine betaine synthesis from glycine" EXACT []
synonym: "N-trimethylglycine biosynthesis from glycine" EXACT []
synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT []
xref: MetaCyc:P541-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0031456 ! glycine betaine biosynthetic process

[Term]
id: GO:0019287
name: isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]
synonym: "Ac-MVA pathway" EXACT [PMID:14517367]
synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367]
synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process via mevalonate" EXACT [GOC:pr]
synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT []
xref: MetaCyc:PWY-922
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process

[Term]
id: GO:0019288
name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY, PMID:18948055]
synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT []
synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:pr]
synonym: "isopentenyl diphosphate biosynthetic process, MEP pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT []
synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT []
synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT []
synonym: "non-MVA pathway" EXACT []
xref: MetaCyc:NONMEVIPP-PWY
is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process

[Term]
id: GO:0019289
name: rhizobactin 1021 biosynthetic process
namespace: biological_process
alt_id: GO:0031193
alt_id: GO:0031194
def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [PMID:11274118]
synonym: "rhizobactin 1021 anabolism" EXACT []
synonym: "rhizobactin 1021 biosynthesis" EXACT []
synonym: "rhizobactin 1021 biosynthetic process, peptide formation" NARROW []
synonym: "rhizobactin 1021 biosynthetic process, peptide modification" NARROW []
synonym: "rhizobactin 1021 formation" EXACT []
synonym: "rhizobactin 1021 synthesis" EXACT []
xref: MetaCyc:PWY-761
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046494 ! rhizobactin 1021 metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0019290
name: siderophore biosynthetic process
namespace: biological_process
alt_id: GO:0031178
alt_id: GO:0031180
def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [PMID:20376388]
synonym: "siderochrome biosynthesis" NARROW []
synonym: "siderochrome biosynthetic process" NARROW []
synonym: "siderophore anabolism" EXACT []
synonym: "siderophore biosynthesis" EXACT []
synonym: "siderophore biosynthetic process, peptide formation" NARROW []
synonym: "siderophore biosynthetic process, peptide modification" NARROW []
synonym: "siderophore formation" EXACT []
synonym: "siderophore synthesis" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0019292
name: L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators]
synonym: "L-tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT []
synonym: "L-tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT []
synonym: "L-tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT []
synonym: "L-tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT []
synonym: "tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate" BROAD []
xref: MetaCyc:TYRSYN
is_a: GO:0006571 ! tyrosine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0019293
name: tyrosine biosynthetic process, by oxidation of phenylalanine
namespace: biological_process
alt_id: GO:0019291
def: "The conversion of phenylalanine to tyrosine." [PMID:4004813]
synonym: "L-tyrosine biosynthesis IV" EXACT []
synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT []
synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT []
synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT []
xref: MetaCyc:PWY-6134
is_a: GO:0006571 ! tyrosine biosynthetic process

[Term]
id: GO:0019294
name: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [ISBN:0198506732]
synonym: "KDO biosynthesis" EXACT []
synonym: "KDO biosynthetic process" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid formation" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT []
synonym: "ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732]
xref: MetaCyc:KDOSYN-PWY
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0019295
name: coenzyme M biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684]
synonym: "coenzyme M anabolism" EXACT []
synonym: "coenzyme M biosynthesis" EXACT []
synonym: "coenzyme M formation" EXACT []
synonym: "coenzyme M synthesis" EXACT []
xref: MetaCyc:P261-PWY
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019296 ! coenzyme M metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0019296
name: coenzyme M metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
synonym: "coenzyme M metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0019297
name: coenzyme B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
synonym: "coenzyme B metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019298
name: coenzyme B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051]
synonym: "coenzyme B anabolism" EXACT []
synonym: "coenzyme B biosynthesis" EXACT []
synonym: "coenzyme B formation" EXACT []
synonym: "coenzyme B synthesis" EXACT []
xref: MetaCyc:P241-PWY
is_a: GO:0019297 ! coenzyme B metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0019299
name: rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732]
synonym: "rhamnose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019300
name: rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732]
synonym: "rhamnose anabolism" EXACT []
synonym: "rhamnose biosynthesis" EXACT []
synonym: "rhamnose formation" EXACT []
synonym: "rhamnose synthesis" EXACT []
is_a: GO:0019299 ! rhamnose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0019301
name: rhamnose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732]
synonym: "rhamnose breakdown" EXACT []
synonym: "rhamnose catabolism" EXACT []
synonym: "rhamnose degradation" EXACT []
xref: MetaCyc:RHAMCAT-PWY
is_a: GO:0019299 ! rhamnose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019302
name: D-ribose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732]
synonym: "D-ribose anabolism" EXACT []
synonym: "D-ribose biosynthesis" EXACT []
synonym: "D-ribose formation" EXACT []
synonym: "D-ribose synthesis" EXACT []
is_a: GO:0006014 ! D-ribose metabolic process
is_a: GO:0019322 ! pentose biosynthetic process

[Term]
id: GO:0019303
name: D-ribose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732]
synonym: "D-ribose breakdown" EXACT []
synonym: "D-ribose catabolism" EXACT []
synonym: "D-ribose degradation" EXACT []
xref: MetaCyc:RIBOKIN-PWY
is_a: GO:0006014 ! D-ribose metabolic process
is_a: GO:0019323 ! pentose catabolic process

[Term]
id: GO:0019304
name: anaerobic rhamnose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai]
synonym: "anaerobic rhamnose breakdown" EXACT []
synonym: "anaerobic rhamnose catabolism" EXACT []
synonym: "anaerobic rhamnose degradation" EXACT []
is_a: GO:0019301 ! rhamnose catabolic process

[Term]
id: GO:0019305
name: dTDP-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
synonym: "dTDP-rhamnose anabolism" EXACT []
synonym: "dTDP-rhamnose biosynthesis" EXACT []
synonym: "dTDP-rhamnose formation" EXACT []
synonym: "dTDP-rhamnose synthesis" EXACT []
xref: MetaCyc:DTDPRHAMSYN-PWY
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046383 ! dTDP-rhamnose metabolic process

[Term]
id: GO:0019306
name: GDP-D-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-D-rhamnose anabolism" EXACT []
synonym: "GDP-D-rhamnose biosynthesis" EXACT []
synonym: "GDP-D-rhamnose formation" EXACT []
synonym: "GDP-D-rhamnose synthesis" EXACT []
xref: MetaCyc:GDPRHAMSYN-PWY
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046382 ! GDP-D-rhamnose metabolic process

[Term]
id: GO:0019307
name: mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai]
synonym: "mannose anabolism" EXACT []
synonym: "mannose biosynthesis" EXACT []
synonym: "mannose formation" EXACT []
synonym: "mannose synthesis" EXACT []
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0019308
name: dTDP-mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
synonym: "dTDP-mannose anabolism" EXACT []
synonym: "dTDP-mannose biosynthesis" EXACT []
synonym: "dTDP-mannose formation" EXACT []
synonym: "dTDP-mannose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046371 ! dTDP-mannose metabolic process

[Term]
id: GO:0019309
name: mannose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai]
synonym: "mannose breakdown" EXACT []
synonym: "mannose catabolism" EXACT []
synonym: "mannose degradation" EXACT []
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019310
name: inositol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:go_curators]
synonym: "inositol breakdown" EXACT []
synonym: "inositol catabolism" EXACT []
synonym: "inositol degradation" EXACT []
synonym: "myo-inositol catabolic process" NARROW []
synonym: "myo-inositol catabolism" NARROW []
synonym: "vitamin Bh catabolic process" EXACT []
synonym: "vitamin Bh catabolism" EXACT []
xref: MetaCyc:P562-PWY
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0019311
name: sorbose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]
synonym: "sorbose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019312
name: L-sorbose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "L-sorbose metabolism" EXACT []
xref: MetaCyc:P302-PWY
is_a: GO:0019311 ! sorbose metabolic process

[Term]
id: GO:0019313
name: obsolete allose metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732]
comment: The reason for obsoletion is that this term is practically equivalent to D-allose metabolic process.
synonym: "allose metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0019314

[Term]
id: GO:0019314
name: D-allose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "D-allose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019315
name: D-allose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "D-allose anabolism" EXACT []
synonym: "D-allose biosynthesis" EXACT []
synonym: "D-allose formation" EXACT []
synonym: "D-allose synthesis" EXACT []
is_a: GO:0019314 ! D-allose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0019316
name: D-allose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "D-allose breakdown" EXACT []
synonym: "D-allose catabolism" EXACT []
synonym: "D-allose degradation" EXACT []
xref: MetaCyc:PWY0-44
is_a: GO:0019314 ! D-allose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019317
name: fucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl]
synonym: "fucose breakdown" EXACT []
synonym: "fucose catabolism" EXACT []
synonym: "fucose degradation" EXACT []
xref: MetaCyc:FUCCAT-PWY
is_a: GO:0006004 ! fucose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019318
name: hexose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0019319
name: hexose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexose anabolism" EXACT []
synonym: "hexose biosynthesis" EXACT []
synonym: "hexose formation" EXACT []
synonym: "hexose synthesis" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0019320
name: hexose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexose breakdown" EXACT []
synonym: "hexose catabolism" EXACT []
synonym: "hexose degradation" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process

[Term]
id: GO:0019321
name: pentose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
synonym: "pentose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0019322
name: pentose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
synonym: "pentose anabolism" EXACT []
synonym: "pentose biosynthesis" EXACT []
synonym: "pentose formation" EXACT []
synonym: "pentose synthesis" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0019323
name: pentose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
synonym: "pentose breakdown" EXACT []
synonym: "pentose catabolism" EXACT []
synonym: "pentose degradation" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process

[Term]
id: GO:0019324
name: L-lyxose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "L-lyxose metabolism" EXACT []
xref: MetaCyc:LYXMET-PWY
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0019325
name: obsolete anaerobic fructose catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai]
comment: The reason for obsoletion is that this term is not clearly defined the meaning is ambiguous.
synonym: "anaerobic fructose breakdown" EXACT []
synonym: "anaerobic fructose catabolism" EXACT []
synonym: "anaerobic fructose degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0019326
name: nitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
synonym: "nitrotoluene metabolism" EXACT []
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0019327
name: lead sulfide oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate." [MetaCyc:P301-PWY]
synonym: "lead sulphide oxidation" EXACT [GOC:mah]
synonym: "oxidation of galena" EXACT []
synonym: "oxidation of lead sulfide" EXACT []
xref: MetaCyc:P301-PWY
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019328
name: anaerobic gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl]
synonym: "anaerobic gallate breakdown" EXACT []
synonym: "anaerobic gallate catabolism" EXACT []
synonym: "anaerobic gallate degradation" EXACT []
synonym: "anaerobic gallic acid catabolic process" EXACT []
synonym: "anaerobic gallic acid catabolism" EXACT []
synonym: "gallate fermentation" EXACT []
xref: MetaCyc:P3-PWY
is_a: GO:0019396 ! gallate catabolic process

[Term]
id: GO:0019329
name: ammonia oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah]
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0019330
name: aldoxime metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [GOC:curators]
synonym: "aldoxime metabolism" EXACT []
xref: MetaCyc:P345-PWY
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019331
name: anaerobic respiration, using ammonium as electron donor
namespace: biological_process
def: "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY]
synonym: "anaerobic ammonium oxidation" BROAD []
synonym: "anammox" EXACT []
xref: MetaCyc:P303-PWY
xref: Wikipedia:Anammox
is_a: GO:0009061 ! anaerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0019329 ! ammonia oxidation

[Term]
id: GO:0019332
name: aerobic respiration, using nitrite as electron donor
namespace: biological_process
def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY]
synonym: "nitrite oxidation" BROAD []
xref: MetaCyc:P282-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019333
name: denitrification pathway
namespace: biological_process
def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY]
xref: MetaCyc:DENITRIFICATION-PWY
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0019334
name: p-cymene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai]
synonym: "p-cymene breakdown" EXACT []
synonym: "p-cymene catabolism" EXACT []
synonym: "p-cymene degradation" EXACT []
xref: MetaCyc:PWY-741
is_a: GO:0018953 ! p-cymene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0019335
name: 3-methylquinoline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai]
synonym: "3-methylquinoline breakdown" EXACT []
synonym: "3-methylquinoline catabolism" EXACT []
synonym: "3-methylquinoline degradation" EXACT []
xref: MetaCyc:PWY-721
is_a: GO:0018930 ! 3-methylquinoline metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0019336
name: phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]
synonym: "phenol-containing compound breakdown" EXACT []
synonym: "phenol-containing compound catabolism" EXACT []
synonym: "phenol-containing compound degradation" EXACT []
xref: MetaCyc:PHENOLDEG-PWY
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0019337
name: tetrachloroethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai, PMID:7988892, PMID:8663199]
synonym: "tetrachloroethene catabolic process" EXACT []
synonym: "tetrachloroethene catabolism" EXACT []
synonym: "tetrachloroethylene breakdown" EXACT []
synonym: "tetrachloroethylene catabolism" EXACT []
synonym: "tetrachloroethylene degradation" EXACT []
xref: MetaCyc:PCEDEG-PWY
xref: UM-BBD_pathwayID:tce2
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0019338
name: pentachlorophenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators]
synonym: "pentachlorophenol breakdown" EXACT []
synonym: "pentachlorophenol catabolism" EXACT []
synonym: "pentachlorophenol degradation" EXACT []
xref: MetaCyc:PCPDEG-PWY
is_a: GO:0018961 ! pentachlorophenol metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process

[Term]
id: GO:0019339
name: parathion catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [MetaCyc:PARATHION-DEGRADATION-PWY]
synonym: "parathion breakdown" EXACT []
synonym: "parathion catabolism" EXACT []
synonym: "parathion degradation" EXACT []
xref: MetaCyc:PARATHION-DEGRADATION-PWY
xref: UM-BBD_pathwayID:pthn
is_a: GO:0018952 ! parathion metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0019340
name: dibenzofuran catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai]
synonym: "dibenzofuran breakdown" EXACT []
synonym: "dibenzofuran catabolism" EXACT []
synonym: "dibenzofuran degradation" EXACT []
xref: MetaCyc:P662-PWY
is_a: GO:0018893 ! dibenzofuran metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0019341
name: dibenzo-p-dioxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai]
synonym: "dibenzo-p-dioxin breakdown" EXACT []
synonym: "dibenzo-p-dioxin catabolism" EXACT []
synonym: "dibenzo-p-dioxin degradation" EXACT []
xref: MetaCyc:P661-PWY
is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0019342
name: trypanothione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355]
synonym: "trypanothione anabolism" EXACT []
synonym: "trypanothione biosynthesis" EXACT []
synonym: "trypanothione formation" EXACT []
synonym: "trypanothione synthesis" EXACT []
xref: MetaCyc:TRYPANOSYN-PWY
is_a: GO:0046206 ! trypanothione metabolic process
is_a: GO:1901687 ! glutathione derivative biosynthetic process

[Term]
id: GO:0019343
name: cysteine biosynthetic process via cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]
synonym: "cysteine anabolism via cystathionine" EXACT []
synonym: "cysteine formation via cystathionine" EXACT []
synonym: "cysteine synthesis via cystathionine" EXACT []
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0019344
name: cysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
synonym: "cysteine anabolism" EXACT []
synonym: "cysteine biosynthesis" EXACT []
synonym: "cysteine formation" EXACT []
synonym: "cysteine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0019345
name: cysteine biosynthetic process via S-sulfo-L-cysteine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators]
synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT []
synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT []
synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT []
synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT []
synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT []
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0019346
name: transsulfuration
namespace: biological_process
def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801]
synonym: "homocysteine-cysteine interconversion" NARROW []
synonym: "transsulphuration" EXACT []
xref: MetaCyc:PWY-801
xref: Wikipedia:Transsulfuration_pathway
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009092 ! homoserine metabolic process
is_a: GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0019347
name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT []
xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0019348
name: dolichol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]
synonym: "dolichol metabolism" EXACT []
is_a: GO:0016093 ! polyprenol metabolic process

[Term]
id: GO:0019349
name: ribitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732]
synonym: "ribitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019350
name: teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732]
synonym: "teichoic acid anabolism" EXACT []
synonym: "teichoic acid biosynthesis" EXACT []
synonym: "teichoic acid formation" EXACT []
synonym: "teichoic acid synthesis" EXACT []
xref: MetaCyc:TEICHOICACID-PWY
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0046374 ! teichoic acid metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0019351
name: dethiobiotin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732]
synonym: "desthiobiotin biosynthesis" EXACT []
synonym: "desthiobiotin biosynthetic process" EXACT []
synonym: "dethiobiotin anabolism" EXACT []
synonym: "dethiobiotin biosynthesis" EXACT []
synonym: "dethiobiotin formation" EXACT []
synonym: "dethiobiotin synthesis" EXACT []
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046450 ! dethiobiotin metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0019352
name: protoporphyrinogen IX biosynthetic process from glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators]
synonym: "protoporphyrinogen IX anabolism from glycine" EXACT []
synonym: "protoporphyrinogen IX formation from glycine" EXACT []
synonym: "protoporphyrinogen IX synthesis from glycine" EXACT []
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process

[Term]
id: GO:0019353
name: protoporphyrinogen IX biosynthetic process from glutamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [PMID:32976912]
synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT []
synonym: "protoporphyrinogen IX formation from glutamate" EXACT []
synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT []
is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process
is_a: GO:0033526 ! tetrapyrrole biosynthetic process from glutamate

[Term]
id: GO:0019354
name: siroheme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732]
synonym: "sirohaem biosynthesis" EXACT []
synonym: "sirohaem biosynthetic process" EXACT []
synonym: "siroheme anabolism" EXACT []
synonym: "siroheme biosynthesis" EXACT []
synonym: "siroheme formation" EXACT []
synonym: "siroheme synthase activity" RELATED []
synonym: "siroheme synthesis" EXACT []
xref: MetaCyc:PWY-5194
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046156 ! siroheme metabolic process

[Term]
id: GO:0019356
name: nicotinate nucleotide biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators]
synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT []
synonym: "nicotinate nucleotide formation from tryptophan" EXACT []
synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0019357
name: nicotinate nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators]
synonym: "nicotinate nucleotide anabolism" EXACT []
synonym: "nicotinate nucleotide biosynthesis" EXACT []
synonym: "nicotinate nucleotide formation" EXACT []
synonym: "nicotinate nucleotide synthesis" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0046497 ! nicotinate nucleotide metabolic process

[Term]
id: GO:0019358
name: nicotinate nucleotide salvage
namespace: biological_process
def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators]
synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT []
synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT []
is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process
is_a: GO:0019365 ! pyridine nucleotide salvage

[Term]
id: GO:0019359
name: nicotinamide nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]
synonym: "nicotinamide nucleotide anabolism" EXACT []
synonym: "nicotinamide nucleotide biosynthesis" EXACT []
synonym: "nicotinamide nucleotide formation" EXACT []
synonym: "nicotinamide nucleotide synthesis" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0019360
name: nicotinamide nucleotide biosynthetic process from niacinamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators]
synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT []
synonym: "nicotinamide nucleotide formation from niacinamide" EXACT []
synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT []
is_a: GO:0006769 ! nicotinamide metabolic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0019361
name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT []
xref: MetaCyc:P2-PWY
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process

[Term]
id: GO:0019362
name: pyridine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]
synonym: "pyridine nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0019363
name: pyridine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw]
synonym: "pyridine nucleotide anabolism" EXACT []
synonym: "pyridine nucleotide biosynthesis" EXACT []
synonym: "pyridine nucleotide formation" EXACT []
synonym: "pyridine nucleotide synthesis" EXACT []
xref: MetaCyc:PYRIDNUCSYN-PWY
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0019364
name: pyridine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw]
synonym: "pyridine nucleotide breakdown" EXACT []
synonym: "pyridine nucleotide catabolism" EXACT []
synonym: "pyridine nucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0019365
name: pyridine nucleotide salvage
namespace: biological_process
def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl]
synonym: "pyridine nucleotide cycling" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0019367
name: fatty acid elongation, saturated fatty acid
namespace: biological_process
def: "Elongation of a saturated fatty acid chain." [GOC:mah]
xref: MetaCyc:FASYN-ELONG-PWY
is_a: GO:0030497 ! fatty acid elongation

[Term]
id: GO:0019368
name: fatty acid elongation, unsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]
xref: MetaCyc:PWY0-862
is_a: GO:0030497 ! fatty acid elongation

[Term]
id: GO:0019369
name: arachidonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732]
synonym: "arachidonic acid metabolic process" EXACT []
synonym: "arachidonic acid metabolism" EXACT []
xref: Wikipedia:Arachidonic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0019370
name: leukotriene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators]
synonym: "leukotriene anabolism" EXACT []
synonym: "leukotriene biosynthesis" EXACT []
synonym: "leukotriene formation" EXACT []
synonym: "leukotriene synthesis" EXACT []
xref: Wikipedia:Leukotriene#Leukotriene_synthesis
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0046456 ! icosanoid biosynthetic process

[Term]
id: GO:0019371
name: cyclooxygenase pathway
namespace: biological_process
def: "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2." [PMID:19854273]
is_a: GO:0019369 ! arachidonate metabolic process
relationship: part_of GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0019372
name: lipoxygenase pathway
namespace: biological_process
def: "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase." [GOC:mah, PMID:17163881]
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0019373
name: epoxygenase P450 pathway
namespace: biological_process
def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids." [GOC:mah, PMID:17979511]
is_a: GO:0019369 ! arachidonate metabolic process

[Term]
id: GO:0019374
name: galactolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732]
synonym: "galactolipid metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process

[Term]
id: GO:0019375
name: galactolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732]
synonym: "galactolipid anabolism" EXACT []
synonym: "galactolipid biosynthesis" EXACT []
synonym: "galactolipid formation" EXACT []
synonym: "galactolipid synthesis" EXACT []
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0019374 ! galactolipid metabolic process

[Term]
id: GO:0019376
name: galactolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732]
synonym: "galactolipid breakdown" EXACT []
synonym: "galactolipid catabolism" EXACT []
synonym: "galactolipid degradation" EXACT []
is_a: GO:0019374 ! galactolipid metabolic process
is_a: GO:0019377 ! glycolipid catabolic process

[Term]
id: GO:0019377
name: glycolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]
synonym: "glycolipid breakdown" EXACT []
synonym: "glycolipid catabolism" EXACT []
synonym: "glycolipid degradation" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046466 ! membrane lipid catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0019379
name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
namespace: biological_process
def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl]
synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT []
xref: MetaCyc:SO4ASSIM-PWY
is_a: GO:0000103 ! sulfate assimilation

[Term]
id: GO:0019380
name: 3-phenylpropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai]
synonym: "3-phenylpropionate breakdown" EXACT []
synonym: "3-phenylpropionate catabolism" EXACT []
synonym: "3-phenylpropionate degradation" EXACT []
xref: MetaCyc:P281-PWY
is_a: GO:0018962 ! 3-phenylpropionate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019381
name: atrazine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, MetaCyc:PWY-5724]
synonym: "atrazine breakdown" EXACT []
synonym: "atrazine catabolism" EXACT []
synonym: "atrazine degradation" EXACT []
xref: MetaCyc:PWY-5724
xref: UM-BBD_pathwayID:atr
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0018873 ! atrazine metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process

[Term]
id: GO:0019382
name: carbon tetrachloride catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators]
synonym: "carbon tetrachloride breakdown" EXACT []
synonym: "carbon tetrachloride catabolism" EXACT []
synonym: "carbon tetrachloride degradation" EXACT []
is_a: GO:0018885 ! carbon tetrachloride metabolic process
is_a: GO:0042206 ! halogenated hydrocarbon catabolic process

[Term]
id: GO:0019383
name: (+)-camphor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [MetaCyc:P601-PWY]
synonym: "(+)-camphor breakdown" EXACT []
synonym: "(+)-camphor catabolism" EXACT []
synonym: "(+)-camphor degradation" EXACT []
xref: MetaCyc:P601-PWY
xref: UM-BBD_pathwayID:cam
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0018882 ! (+)-camphor metabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0019384
name: caprolactam catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [GOC:curators]
synonym: "caprolactam breakdown" EXACT []
synonym: "caprolactam catabolism" EXACT []
synonym: "caprolactam degradation" EXACT []
xref: MetaCyc:P621-PWY
is_a: GO:0018883 ! caprolactam metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072340 ! lactam catabolic process

[Term]
id: GO:0019385
name: methanogenesis, from acetate
namespace: biological_process
def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai]
synonym: "methane biosynthesis from acetate" EXACT []
synonym: "methane biosynthetic process from acetate" EXACT []
xref: MetaCyc:METH-ACETATE-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019386
name: methanogenesis, from carbon dioxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai]
synonym: "methane biosynthesis from carbon dioxide" EXACT []
synonym: "methane biosynthetic process from carbon dioxide" EXACT []
xref: MetaCyc:METHANOGENESIS-PWY
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019387
name: methanogenesis, from methanol
namespace: biological_process
def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai]
synonym: "methane biosynthesis from methanol" EXACT []
synonym: "methane biosynthetic process from methanol" EXACT []
xref: MetaCyc:METHFORM-PWY
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019388
name: galactose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732]
synonym: "galactose breakdown" EXACT []
synonym: "galactose catabolism" EXACT []
synonym: "galactose degradation" EXACT []
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019389
name: obsolete glucuronoside metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "glucuronide metabolic process" EXACT []
synonym: "glucuronide metabolism" EXACT []
synonym: "glucuronoside metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0019390
name: obsolete glucuronoside biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "glucuronide biosynthesis" EXACT []
synonym: "glucuronide biosynthetic process" EXACT []
synonym: "glucuronoside anabolism" EXACT []
synonym: "glucuronoside biosynthesis" EXACT []
synonym: "glucuronoside formation" EXACT []
synonym: "glucuronoside synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0019391
name: obsolete glucuronoside catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "glucuronide catabolic process" EXACT []
synonym: "glucuronide catabolism" EXACT []
synonym: "glucuronoside breakdown" EXACT []
synonym: "glucuronoside catabolism" EXACT []
synonym: "glucuronoside degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0019392
name: glucarate metabolic process
namespace: biological_process
alt_id: GO:0019581
def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732]
synonym: "glucarate metabolism" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process

[Term]
id: GO:0019393
name: glucarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732]
synonym: "glucarate anabolism" EXACT []
synonym: "glucarate biosynthesis" EXACT []
synonym: "glucarate formation" EXACT []
synonym: "glucarate synthesis" EXACT []
is_a: GO:0019392 ! glucarate metabolic process
is_a: GO:0019578 ! aldaric acid biosynthetic process

[Term]
id: GO:0019394
name: glucarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732]
synonym: "glucarate breakdown" EXACT []
synonym: "glucarate catabolism" EXACT []
synonym: "glucarate degradation" EXACT []
xref: MetaCyc:GLUCARDEG-PWY
is_a: GO:0019392 ! glucarate metabolic process
is_a: GO:0019579 ! aldaric acid catabolic process

[Term]
id: GO:0019395
name: fatty acid oxidation
namespace: biological_process
def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732]
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0034440 ! lipid oxidation

[Term]
id: GO:0019396
name: gallate catabolic process
namespace: biological_process
alt_id: GO:0018918
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl]
synonym: "gallate breakdown" EXACT []
synonym: "gallate catabolism" EXACT []
synonym: "gallate degradation" EXACT []
synonym: "gallate metabolic process" RELATED []
synonym: "gallate metabolism" RELATED []
synonym: "gallic acid catabolic process" EXACT []
synonym: "gallic acid catabolism" EXACT []
synonym: "gallic acid metabolic process" RELATED []
synonym: "gallic acid metabolism" RELATED []
xref: UM-BBD_pathwayID:gal
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019397
name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl]
synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT []
xref: MetaCyc:GALLATE-DEGRADATION-I-PWY
is_a: GO:0042195 ! aerobic gallate catabolic process

[Term]
id: GO:0019398
name: gallate catabolic process via gallate dioxygenase activity
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase." [GOC:bf, GOC:jl]
synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" BROAD [GOC:bf]
synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
xref: MetaCyc:GALLATE-DEGRADATION-II-PWY
is_a: GO:0042195 ! aerobic gallate catabolic process

[Term]
id: GO:0019399
name: cyclohexanol oxidation
namespace: biological_process
def: "The cyclohexanol metabolic process in which cyclohexanol is converted to adipate." [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY]
xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY
is_a: GO:0018891 ! cyclohexanol metabolic process

[Term]
id: GO:0019400
name: alditol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]
synonym: "alditol metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:0019401
name: alditol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]
synonym: "alditol anabolism" EXACT []
synonym: "alditol biosynthesis" EXACT []
synonym: "alditol formation" EXACT []
synonym: "alditol synthesis" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0019400 ! alditol metabolic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0019402
name: galactitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732]
synonym: "galactitol metabolism" EXACT []
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0019403
name: galactitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732]
synonym: "galactitol anabolism" EXACT []
synonym: "galactitol biosynthesis" EXACT []
synonym: "galactitol formation" EXACT []
synonym: "galactitol synthesis" EXACT []
is_a: GO:0019402 ! galactitol metabolic process
is_a: GO:0019406 ! hexitol biosynthetic process

[Term]
id: GO:0019404
name: galactitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732]
synonym: "galactitol breakdown" EXACT []
synonym: "galactitol catabolism" EXACT []
synonym: "galactitol degradation" EXACT []
xref: MetaCyc:GALACTITOLCAT-PWY
is_a: GO:0019402 ! galactitol metabolic process
is_a: GO:0019407 ! hexitol catabolic process

[Term]
id: GO:0019405
name: alditol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]
synonym: "alditol breakdown" EXACT []
synonym: "alditol catabolism" EXACT []
synonym: "alditol degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019400 ! alditol metabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0019406
name: hexitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexitol anabolism" EXACT []
synonym: "hexitol biosynthesis" EXACT []
synonym: "hexitol formation" EXACT []
synonym: "hexitol synthesis" EXACT []
is_a: GO:0006059 ! hexitol metabolic process
is_a: GO:0019401 ! alditol biosynthetic process

[Term]
id: GO:0019407
name: hexitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexitol breakdown" EXACT []
synonym: "hexitol catabolism" EXACT []
synonym: "hexitol degradation" EXACT []
is_a: GO:0006059 ! hexitol metabolic process
is_a: GO:0019405 ! alditol catabolic process

[Term]
id: GO:0019408
name: dolichol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]
synonym: "dolichol anabolism" EXACT []
synonym: "dolichol biosynthesis" EXACT []
synonym: "dolichol formation" EXACT []
synonym: "dolichol synthesis" EXACT []
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0019348 ! dolichol metabolic process

[Term]
id: GO:0019409
name: aerobic respiration, using ammonia as electron donor
namespace: biological_process
def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite." [MetaCyc:AMMOXID-PWY]
synonym: "aerobic ammonia oxidation to nitrite via hydrazine" EXACT [GOC:mah]
xref: MetaCyc:AMMOXID-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0019329 ! ammonia oxidation

[Term]
id: GO:0019410
name: aerobic respiration, using carbon monoxide as electron donor
namespace: biological_process
def: "The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation." [PMID:18024677]
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019411
name: aerobic respiration, using ferrous ions as electron donor
namespace: biological_process
def: "The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide." [ISBN:3131084111]
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019412
name: aerobic respiration, using hydrogen as electron donor
namespace: biological_process
def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY]
synonym: "hydrogen oxidation" BROAD []
xref: MetaCyc:P283-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019413
name: acetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "acetate anabolism" EXACT []
synonym: "acetate biosynthesis" EXACT []
synonym: "acetate formation" EXACT []
synonym: "acetate synthesis" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0019414
name: aerobic respiration, using sulfur or sulfate as electron donor
namespace: biological_process
def: "An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized." [PMID:11425697]
synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT []
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019415
name: acetate biosynthetic process from carbon monoxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators]
synonym: "acetate anabolism from carbon monoxide" EXACT []
synonym: "acetate formation from carbon monoxide" EXACT []
synonym: "acetate synthesis from carbon monoxide" EXACT []
synonym: "carbon monoxide dehydrogenase pathway" EXACT []
is_a: GO:0019413 ! acetate biosynthetic process

[Term]
id: GO:0019416
name: polythionate oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor." [MetaCyc:THIOSULFOX-PWY]
xref: MetaCyc:THIOSULFOX-PWY
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0019417
name: sulfur oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl]
synonym: "sulphur oxidation" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0019418
name: sulfide oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:Sulfide-Oxidation]
synonym: "sulphide oxidation" EXACT []
xref: MetaCyc:Sulfide-Oxidation
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0019419
name: obsolete sulfate reduction
namespace: biological_process
alt_id: GO:0019421
def: "OBSOLETE. The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate." [MetaCyc:SULFMETII-PWY]
comment: This term was obsoleted because it has the same meaning as sulfate assimilation ; GO:0000103.
synonym: "assimilatory sulfate reduction" NARROW []
synonym: "assimilatory sulphate reduction" NARROW []
synonym: "sulfate reduction, APS pathway" NARROW []
synonym: "sulphate reduction" EXACT []
synonym: "sulphate reduction, APS pathway" NARROW []
is_obsolete: true
replaced_by: GO:0000103

[Term]
id: GO:0019420
name: dissimilatory sulfate reduction
namespace: biological_process
def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [PMID:25400653, PMID:26680199]
synonym: "dissimilatory sulphate reduction" EXACT []
xref: MetaCyc:DISSULFRED-PWY
xref: Wikipedia:Sulfate-reducing_microorganism
is_a: GO:0000103 ! sulfate assimilation
is_a: GO:0009061 ! anaerobic respiration

[Term]
id: GO:0019422
name: disproportionation of elemental sulfur
namespace: biological_process
def: "The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY]
synonym: "disproportionation of elemental sulphur" EXACT []
xref: MetaCyc:P203-PWY
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0019423
name: sulfur oxidation, ferric ion-dependent
namespace: biological_process
def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+)." [MetaCyc:FESULFOX-PWY]
synonym: "sulphur oxidation, ferric ion-dependent" EXACT []
xref: MetaCyc:FESULFOX-PWY
is_a: GO:0019417 ! sulfur oxidation

[Term]
id: GO:0019424
name: obsolete sulfide oxidation, using siroheme sulfite reductase
namespace: biological_process
alt_id: GO:0019425
def: "OBSOLETE. A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase." [MetaCyc:P223-PWY]
comment: This term was obsoleted because the corresponding MetaCyc pathway was deprecated.
synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT []
synonym: "sulfur oxidation, using sirohaem sulfite reductase" RELATED []
synonym: "sulfur oxidation, using siroheme sulfite reductase" RELATED []
synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT []
synonym: "sulphur oxidation, using siroheme sulphite reductase" RELATED []
is_obsolete: true
replaced_by: GO:0019418

[Term]
id: GO:0019426
name: obsolete bisulfite reduction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite." [MetaCyc:P224-PWY]
comment: This term was obsoleted because it was solely defined by a MetaCyc pathway that is now deprecated.
synonym: "bisulphite reduction" EXACT []
is_obsolete: true

[Term]
id: GO:0019427
name: acetyl-CoA biosynthetic process from acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY]
synonym: "acetate utilization" RELATED []
synonym: "acetyl-CoA anabolism from acetate" EXACT []
synonym: "acetyl-CoA formation from acetate" EXACT []
synonym: "acetyl-CoA synthesis from acetate" EXACT []
xref: MetaCyc:ACETATEUTIL-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006085 ! acetyl-CoA biosynthetic process

[Term]
id: GO:0019428
name: allantoin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators]
synonym: "allantoin anabolism" EXACT []
synonym: "allantoin biosynthesis" EXACT []
synonym: "allantoin formation" EXACT []
synonym: "allantoin synthesis" EXACT []
xref: MetaCyc:URSIN-PWY
is_a: GO:0000255 ! allantoin metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0019429
name: fluorene catabolic process
namespace: biological_process
alt_id: GO:0018917
def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [PMID:15317800]
synonym: "fluorene breakdown" EXACT []
synonym: "fluorene catabolism" EXACT []
synonym: "fluorene degradation" EXACT []
synonym: "fluorene metabolic process" NARROW []
synonym: "fluorene metabolism" EXACT []
xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY
xref: UM-BBD_pathwayID:flu
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0019430
name: removal of superoxide radicals
namespace: biological_process
def: "Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [GOC:jl]
synonym: "cellular detoxification of superoxide radicals" EXACT [GOC:dos]
synonym: "removal of O2-" EXACT []
synonym: "removal of oxygen free radicals" EXACT []
xref: MetaCyc:DETOX1-PWY
is_a: GO:0006801 ! superoxide metabolic process
is_a: GO:0098869 ! cellular oxidant detoxification
relationship: part_of GO:0071451 ! cellular response to superoxide

[Term]
id: GO:0019431
name: acetyl-CoA biosynthetic process from ethanol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators]
synonym: "acetyl-CoA anabolism from ethanol" EXACT []
synonym: "acetyl-CoA formation from ethanol" EXACT []
synonym: "acetyl-CoA synthesis from ethanol" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0019432
name: triglyceride biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]
synonym: "triacylglycerol biosynthesis" EXACT []
synonym: "triacylglycerol biosynthetic process" EXACT []
synonym: "triglyceride anabolism" EXACT []
synonym: "triglyceride biosynthesis" EXACT []
synonym: "triglyceride formation" EXACT []
synonym: "triglyceride synthesis" EXACT []
xref: MetaCyc:TRIGLSYN-PWY
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0019433
name: triglyceride catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]
synonym: "triacylglycerol catabolic process" EXACT []
synonym: "triacylglycerol catabolism" EXACT []
synonym: "triglyceride breakdown" EXACT []
synonym: "triglyceride catabolism" EXACT []
synonym: "triglyceride degradation" EXACT []
xref: MetaCyc:LIPAS-PWY
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process

[Term]
id: GO:0019434
name: sophorosyloxydocosanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [GOC:curators]
synonym: "sophorosyloxydocosanoate metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process

[Term]
id: GO:0019435
name: sophorosyloxydocosanoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai]
synonym: "sophorosyloxydocosanoate anabolism" EXACT []
synonym: "sophorosyloxydocosanoate biosynthesis" EXACT []
synonym: "sophorosyloxydocosanoate formation" EXACT []
synonym: "sophorosyloxydocosanoate synthesis" EXACT []
xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process

[Term]
id: GO:0019436
name: sophorosyloxydocosanoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai]
synonym: "sophorosyloxydocosanoate breakdown" EXACT []
synonym: "sophorosyloxydocosanoate catabolism" EXACT []
synonym: "sophorosyloxydocosanoate degradation" EXACT []
xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY
is_a: GO:0019377 ! glycolipid catabolic process
is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process

[Term]
id: GO:0019438
name: obsolete aromatic compound biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009058

[Term]
id: GO:0019439
name: obsolete aromatic compound catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009056

[Term]
id: GO:0019440
name: tryptophan catabolic process to indole-3-acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators]
synonym: "tryptophan breakdown to indole-3-acetate" EXACT []
synonym: "tryptophan catabolic process to IAA" EXACT []
synonym: "tryptophan catabolic process to indoleacetic acid" EXACT []
synonym: "tryptophan catabolism to indoleacetic acid" EXACT []
synonym: "tryptophan degradation to indole-3-acetate" EXACT []
xref: MetaCyc:TRPIAACAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0009683 ! indoleacetic acid metabolic process

[Term]
id: GO:0019441
name: tryptophan catabolic process to kynurenine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
synonym: "tryptophan breakdown to kynurenine" EXACT []
synonym: "tryptophan degradation to kynurenine" EXACT []
xref: MetaCyc:TRPKYNCAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0070189 ! kynurenine metabolic process

[Term]
id: GO:0019442
name: tryptophan catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators]
synonym: "tryptophan breakdown to acetyl-CoA" EXACT []
synonym: "tryptophan degradation to acetyl-CoA" EXACT []
xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0043605 ! amide catabolic process

[Term]
id: GO:0019443
name: obsolete tryptophan catabolic process, using tryptophanase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl]
comment: This term was made obsolete because it refers to a one-step pathway.
synonym: "tryptophan breakdown, using tryptophanase" EXACT []
synonym: "tryptophan catabolic process, using tryptophanase" EXACT []
synonym: "tryptophan degradation, using tryptophanase" EXACT []
is_obsolete: true
consider: GO:0006569
consider: GO:0009034

[Term]
id: GO:0019444
name: tryptophan catabolic process to catechol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators]
synonym: "tryptophan breakdown to catechol" EXACT []
synonym: "tryptophan degradation to catechol" EXACT []
xref: MetaCyc:TRPCAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process

[Term]
id: GO:0019445
name: tyrosine catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators]
synonym: "tyrosine breakdown to fumarate" EXACT []
synonym: "tyrosine degradation to fumarate" EXACT []
xref: MetaCyc:TYRFUMCAT-PWY
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0006572 ! tyrosine catabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019446
name: obsolete tyrosine catabolic process to phosphoenolpyruvate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators]
comment: The reason for obsoletion is that there is no evidence that this is a real process.
synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT []
synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT []
is_obsolete: true

[Term]
id: GO:0019447
name: D-cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [PMID:11527960]
synonym: "D-cysteine breakdown" EXACT []
synonym: "D-cysteine catabolism" EXACT []
synonym: "D-cysteine degradation" EXACT []
is_a: GO:0009093 ! cysteine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046438 ! D-cysteine metabolic process

[Term]
id: GO:0019448
name: L-cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [GOC:jsg, GOC:mah]
synonym: "L-cysteine breakdown" EXACT []
synonym: "L-cysteine catabolism" EXACT []
synonym: "L-cysteine degradation" EXACT []
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0009093 ! cysteine catabolic process
is_a: GO:0046439 ! L-cysteine metabolic process

[Term]
id: GO:0019449
name: L-cysteine catabolic process to hypotaurine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators]
synonym: "L-cysteine breakdown to hypotaurine" EXACT []
synonym: "L-cysteine degradation to hypotaurine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019450
name: L-cysteine catabolic process to pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators]
synonym: "L-cysteine breakdown to pyruvate" EXACT []
synonym: "L-cysteine degradation to pyruvate" EXACT []
xref: MetaCyc:LCYSDEG-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019451
name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl]
synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT []
synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT []
xref: MetaCyc:CYSTEINE-DEG-PWY
is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate

[Term]
id: GO:0019452
name: L-cysteine catabolic process to taurine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators]
synonym: "L-cysteine breakdown to taurine" EXACT []
synonym: "L-cysteine degradation to taurine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process
is_a: GO:0019530 ! taurine metabolic process

[Term]
id: GO:0019453
name: L-cysteine catabolic process via cystine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators]
synonym: "L-cysteine breakdown via cystine" EXACT []
synonym: "L-cysteine degradation via cystine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019454
name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase." [GOC:jl]
synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT []
synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019455
name: L-cysteine catabolic process via cystine, using cystine reductase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase." [GOC:jl]
synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT []
synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019456
name: L-cysteine catabolic process via cystine, using cysteine transaminase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase." [GOC:jl]
synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT []
synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019457
name: methionine catabolic process to succinyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators]
synonym: "methionine breakdown to succinyl-CoA" EXACT []
synonym: "methionine degradation to succinyl-CoA" EXACT []
xref: MetaCyc:METHIONINE-DEG1-PWY
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0009087 ! methionine catabolic process
is_a: GO:0043605 ! amide catabolic process

[Term]
id: GO:0019458
name: methionine catabolic process via 2-oxobutanoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators]
synonym: "methionine breakdown via 2-oxobutanoate" EXACT []
synonym: "methionine degradation via 2-oxobutanoate" EXACT []
xref: MetaCyc:PWY-701
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0019460
name: obsolete glutamine catabolic process to fumarate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate." [GOC:go_curators]
comment: The reason for obsoletion is that this term is the same as the parent term.
synonym: "glutamate catabolic process to fumarate" NARROW [GOC:bf, GOC:jl]
synonym: "glutamine breakdown to fumarate" EXACT []
synonym: "glutamine degradation to fumarate" EXACT []
is_obsolete: true
replaced_by: GO:0006543

[Term]
id: GO:0019461
name: obsolete glutamine catabolic process to fumarate, using glutamate synthase (NADPH)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:bf, GOC:jl]
comment: The reason for obsoletion is that this term is defined by a single-step process.
synonym: "glutamate catabolic process to fumarate, using glutamate synthase (NADPH)" RELATED [GOC:bf, GOC:jl]
synonym: "glutamine breakdown to fumarate, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamine degradation to fumarate, using glutamate synthase (NADPH)" EXACT []
is_obsolete: true
replaced_by: GO:0006543

[Term]
id: GO:0019462
name: obsolete glutamine catabolic process to fumarate, using glutaminase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:bf, GOC:jl]
comment: The reason for obsoletion is that this term is defined by a single-step process.
synonym: "glutamate catabolic process to fumarate, using glutaminase" RELATED [GOC:bf, GOC:jl]
synonym: "glutamine breakdown to fumarate, using glutaminase" EXACT []
synonym: "glutamine degradation to fumarate, using glutaminase" NARROW []
is_obsolete: true
replaced_by: GO:0006543

[Term]
id: GO:0019463
name: obsolete glycine catabolic process to creatine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "glycine breakdown to creatine" EXACT []
synonym: "glycine degradation to creatine" EXACT []
is_obsolete: true

[Term]
id: GO:0019464
name: glycine decarboxylation via glycine cleavage system
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY]
synonym: "glycine cleavage system" BROAD []
xref: MetaCyc:GLYCLEAV-PWY
is_a: GO:0006546 ! glycine catabolic process

[Term]
id: GO:0019465
name: obsolete aspartate transamidation
namespace: biological_process
def: "OBSOLETE. The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019466
name: ornithine catabolic process via proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators]
synonym: "ornithine breakdown via proline" EXACT []
synonym: "ornithine degradation via proline" EXACT []
xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0006593 ! ornithine catabolic process

[Term]
id: GO:0019467
name: ornithine catabolic process, by decarboxylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators]
synonym: "ornithine breakdown, by decarboxylation" EXACT []
synonym: "ornithine degradation, by decarboxylation" EXACT []
xref: MetaCyc:ORNDEG-PWY
is_a: GO:0006593 ! ornithine catabolic process

[Term]
id: GO:0019468
name: obsolete nopaline catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "nopaline breakdown" EXACT []
synonym: "nopaline catabolism" EXACT []
synonym: "nopaline degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0019469
name: obsolete octopine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "octopine breakdown" EXACT []
synonym: "octopine catabolism" EXACT []
synonym: "octopine degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0019470
name: 4-hydroxyproline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai]
synonym: "4-hydroxyproline breakdown" EXACT []
synonym: "4-hydroxyproline catabolism" EXACT []
synonym: "4-hydroxyproline degradation" EXACT []
xref: MetaCyc:HYDROXYPRODEG-PWY
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019471
name: 4-hydroxyproline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [GOC:ai]
synonym: "4-hydroxyproline metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0019472
name: 4-hydroxyproline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai]
synonym: "4-hydroxyproline anabolism" EXACT []
synonym: "4-hydroxyproline biosynthesis" EXACT []
synonym: "4-hydroxyproline formation" EXACT []
synonym: "4-hydroxyproline synthesis" EXACT []
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0019473
name: L-lysine catabolic process to glutarate, by acetylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators]
synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT []
synonym: "L-lysine degradation to glutarate, by acetylation" EXACT []
xref: MetaCyc:LYSDEGII-PWY
is_a: GO:0019477 ! L-lysine catabolic process

[Term]
id: GO:0019474
name: L-lysine catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators]
synonym: "L-lysine breakdown to acetyl-CoA" EXACT []
synonym: "L-lysine degradation to acetyl-CoA" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0019477 ! L-lysine catabolic process
is_a: GO:0043605 ! amide catabolic process

[Term]
id: GO:0019475
name: L-lysine catabolic process to acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators]
synonym: "L-lysine breakdown to acetate" EXACT []
synonym: "L-lysine degradation to acetate" EXACT []
synonym: "lysine fermentation" EXACT []
xref: MetaCyc:P163-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0019477 ! L-lysine catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation

[Term]
id: GO:0019476
name: D-lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "D-lysine breakdown" EXACT []
synonym: "D-lysine catabolism" EXACT []
synonym: "D-lysine degradation" EXACT []
is_a: GO:0006554 ! lysine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046441 ! D-lysine metabolic process

[Term]
id: GO:0019477
name: L-lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah]
synonym: "L-lysine breakdown" EXACT []
synonym: "L-lysine catabolism" EXACT []
synonym: "L-lysine degradation" EXACT []
is_a: GO:0006554 ! lysine catabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process
is_a: GO:0046440 ! L-lysine metabolic process

[Term]
id: GO:0019478
name: D-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
synonym: "D-amino acid breakdown" EXACT []
synonym: "D-amino acid catabolism" EXACT []
synonym: "D-amino acid degradation" EXACT []
is_a: GO:0046416 ! D-amino acid metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019479
name: L-alanine oxidation to D-lactate and ammonia
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia." [MetaCyc:ALACAT2-PWY]
xref: MetaCyc:ALACAT2-PWY
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019480
name: L-alanine oxidation to pyruvate via D-alanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate." [MetaCyc:ALADEG-PWY]
xref: MetaCyc:ALADEG-PWY
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019481
name: L-alanine catabolic process, by transamination
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators]
synonym: "L-alanine breakdown, by transamination" EXACT []
synonym: "L-alanine degradation, by transamination" EXACT []
xref: MetaCyc:ALANINE-DEG3-PWY
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019482
name: beta-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
synonym: "beta-alanine metabolism" EXACT []
xref: Wikipedia:Beta-alanine
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0019483
name: beta-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
synonym: "beta-alanine anabolism" EXACT []
synonym: "beta-alanine biosynthesis" EXACT []
synonym: "beta-alanine formation" EXACT []
synonym: "beta-alanine synthesis" EXACT []
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0019482 ! beta-alanine metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0019484
name: beta-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
synonym: "beta-alanine breakdown" EXACT []
synonym: "beta-alanine catabolism" EXACT []
synonym: "beta-alanine degradation" EXACT []
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0019482 ! beta-alanine metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0019485
name: beta-alanine catabolic process to L-alanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators]
synonym: "beta-alanine breakdown to L-alanine" EXACT []
synonym: "beta-alanine degradation to L-alanine" EXACT []
is_a: GO:0019484 ! beta-alanine catabolic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0019486
name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators]
synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT []
synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT []
xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY
is_a: GO:0019484 ! beta-alanine catabolic process

[Term]
id: GO:0019487
name: anaerobic acetylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544]
synonym: "anaerobic acetylene breakdown" EXACT []
synonym: "anaerobic acetylene catabolism" EXACT []
synonym: "anaerobic acetylene degradation" EXACT []
synonym: "anaerobic ethyne catabolic process" EXACT []
synonym: "anaerobic ethyne catabolism" EXACT []
xref: MetaCyc:P161-PWY
is_a: GO:0018864 ! acetylene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043454 ! alkyne catabolic process

[Term]
id: GO:0019488
name: ribitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY]
synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "ribitol degradation to xylulose 5-phosphate" EXACT []
synonym: "ribitol utilization" RELATED []
xref: MetaCyc:RIBITOLUTIL-PWY
is_a: GO:0046363 ! ribitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019489
name: methylgallate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
synonym: "methylgallate metabolism" EXACT []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0019490
name: 2-aminobenzenesulfonate desulfonation
namespace: biological_process
def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [MetaCyc:2ASDEG-PWY]
synonym: "2-aminobenzenesulphonate desulphonation" EXACT []
xref: MetaCyc:2ASDEG-PWY
xref: UM-BBD_pathwayID:abs
is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process

[Term]
id: GO:0019491
name: ectoine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
synonym: "ectoine anabolism" EXACT []
synonym: "ectoine biosynthesis" EXACT []
synonym: "ectoine formation" EXACT []
synonym: "ectoine synthesis" EXACT []
xref: MetaCyc:P101-PWY
is_a: GO:0042399 ! ectoine metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0019492
name: proline salvage
namespace: biological_process
def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl]
synonym: "proline cycling" EXACT []
is_a: GO:0006561 ! proline biosynthetic process
is_a: GO:0043102 ! amino acid salvage

[Term]
id: GO:0019493
name: arginine catabolic process to proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators]
synonym: "arginine breakdown to proline" EXACT []
synonym: "arginine degradation to proline" EXACT []
xref: MetaCyc:ARG-PRO-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006560 ! proline metabolic process

[Term]
id: GO:0019495
name: proline catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators]
synonym: "proline breakdown to 2-oxoglutarate" EXACT []
synonym: "proline catabolic process to 2-ketoglutarate" EXACT []
synonym: "proline catabolic process to alpha-ketoglutarate" EXACT []
synonym: "proline catabolic process to alpha-oxoglutarate" EXACT []
synonym: "proline catabolism to 2-ketoglutarate" EXACT []
synonym: "proline catabolism to alpha-ketoglutarate" EXACT []
synonym: "proline catabolism to alpha-oxoglutarate" EXACT []
synonym: "proline degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006562 ! proline catabolic process

[Term]
id: GO:0019496
name: serine-isocitrate lyase pathway
namespace: biological_process
def: "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide." [ISBN:0387961534]
is_a: GO:0006730 ! one-carbon metabolic process

[Term]
id: GO:0019497
name: hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch]
synonym: "hexachlorocyclohexane metabolism" EXACT []
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0019498
name: n-octane oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA." [MetaCyc:P221-PWY]
xref: MetaCyc:P221-PWY
is_a: GO:0018939 ! n-octane metabolic process

[Term]
id: GO:0019499
name: cyanide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732]
synonym: "cyanide metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019500
name: cyanide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732]
synonym: "cyanide breakdown" EXACT []
synonym: "cyanide catabolism" EXACT []
synonym: "cyanide degradation" EXACT []
xref: MetaCyc:P401-PWY
is_a: GO:0009056 ! catabolic process
is_a: GO:0019499 ! cyanide metabolic process

[Term]
id: GO:0019501
name: arsonoacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl]
synonym: "arsonoacetate breakdown" EXACT []
synonym: "arsonoacetate catabolism" EXACT []
synonym: "arsonoacetate degradation" EXACT []
xref: MetaCyc:P482-PWY
is_a: GO:0018872 ! arsonoacetate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019502
name: L-proline betaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [GOC:curators]
synonym: "stachydrine metabolic process" EXACT []
synonym: "stachydrine metabolism" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0019503
name: L-proline betaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai, PMID:14367364]
synonym: "stachydrine anabolism" EXACT []
synonym: "stachydrine biosynthesis" EXACT []
synonym: "stachydrine biosynthetic process" EXACT []
synonym: "stachydrine formation" EXACT []
synonym: "stachydrine synthesis" EXACT []
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0019502 ! L-proline betaine metabolic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0019504
name: L-proline betaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [PMID:10689197, PMID:1804402, PMID:24520058]
synonym: "stachydrine breakdown" EXACT []
synonym: "stachydrine catabolic process" EXACT []
synonym: "stachydrine catabolism" EXACT []
synonym: "stachydrine degradation" EXACT []
xref: MetaCyc:P561-PWY
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019502 ! L-proline betaine metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0019505
name: resorcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, PMID:33145, PMID:7217008]
synonym: "1,3-benzenediol metabolic process" EXACT []
synonym: "1,3-benzenediol metabolism" EXACT []
synonym: "1,3-dihydroxybenzene metabolic process" EXACT []
synonym: "1,3-dihydroxybenzene metabolism" EXACT []
synonym: "resorcinol metabolism" EXACT []
xref: MetaCyc:P343-PWY
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0019506
name: phenylmercury acetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai]
synonym: "phenylmercury acetate breakdown" EXACT []
synonym: "phenylmercury acetate catabolism" EXACT []
synonym: "phenylmercury acetate degradation" EXACT []
xref: MetaCyc:P641-PWY
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046412 ! phenylmercury acetate metabolic process

[Term]
id: GO:0019507
name: pyridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:curators]
synonym: "pyridine metabolism" EXACT []
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0019508
name: 2,5-dihydroxypyridine catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722]
synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT []
synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT []
synonym: "2,5-dihydroxypyridine utilization" RELATED []
synonym: "maleamate pathway" EXACT []
synonym: "pyridine-2,5-diol catabolic process to fumarate" EXACT []
xref: MetaCyc:PWY-722
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process

[Term]
id: GO:0019509
name: L-methionine salvage from methylthioadenosine
namespace: biological_process
def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]
synonym: "methionine recycling" NARROW []
synonym: "methionine regeneration" NARROW []
synonym: "methionine salvage from methylthioadenosine" EXACT [GOC:mah]
synonym: "methionine salvage pathway" EXACT []
xref: MetaCyc:PWY-4361
is_a: GO:0071267 ! L-methionine salvage

[Term]
id: GO:0019510
name: S-adenosylhomocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732]
synonym: "S-adenosylhomocysteine breakdown" EXACT []
synonym: "S-adenosylhomocysteine catabolism" EXACT []
synonym: "S-adenosylhomocysteine degradation" EXACT []
xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0019511
name: peptidyl-proline hydroxylation
namespace: biological_process
alt_id: GO:0006472
def: "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0019512
name: lactose catabolic process via tagatose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators]
synonym: "lactose breakdown via tagatose-6-phosphate" EXACT []
synonym: "lactose degradation via tagatose-6-phosphate" EXACT []
xref: MetaCyc:LACTOSECAT-PWY
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019513
name: lactose catabolic process, using glucoside 3-dehydrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase." [GOC:jl]
synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT []
synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT []
xref: MetaCyc:LACTOSEUTIL-PWY
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019514
name: obsolete lactose hydrolysis
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because hydrolysis is a reaction.
synonym: "lactose hydrolysis" EXACT []
is_obsolete: true
consider: GO:0004565

[Term]
id: GO:0019515
name: lactose catabolic process via UDP-galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators]
synonym: "lactose breakdown via UDP-galactose" EXACT []
synonym: "lactose degradation via UDP-galactose" EXACT []
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019516
name: obsolete lactate oxidation
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons." [GOC:mah]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006089

[Term]
id: GO:0019517
name: L-threonine catabolic process to D-lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:bf, GOC:jl, MetaCyc:THRDLCTCAT-PWY]
synonym: "L-threonine breakdown to D-lactate" EXACT [GOC:bf]
synonym: "L-threonine catabolic process to (R)-lactate" BROAD [GOC:bf]
synonym: "L-threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY]
synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to D-lactate" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to D-lactate" EXACT [GOC:bf]
synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf]
xref: MetaCyc:THRDLCTCAT-PWY
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0019518
name: L-threonine catabolic process to glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine." [GOC:bf, GOC:mah, MetaCyc:THREONINE-DEG2-PWY]
synonym: "L-threonine breakdown to glycine" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to glycine" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to glycine" EXACT [GOC:bf, GOC:mah]
synonym: "threonine catabolic process to glycine" BROAD [GOC:bf]
xref: MetaCyc:THREONINE-DEG2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0019519
name: pentitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
synonym: "pentitol metabolism" EXACT []
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0019520
name: aldonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732]
synonym: "aldonic acid metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019521
name: D-gluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732]
synonym: "D-gluconate metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019522
name: ketogluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732]
synonym: "ketogluconate metabolism" EXACT []
xref: MetaCyc:KETOGLUCONMET-PWY
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019523
name: L-idonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai]
synonym: "L-idonate metabolism" EXACT []
xref: MetaCyc:IDNCAT-PWY
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019524
name: keto-D-gluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732]
synonym: "keto-D-gluconate breakdown" EXACT []
synonym: "keto-D-gluconate catabolism" EXACT []
synonym: "keto-D-gluconate degradation" EXACT []
xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY
is_a: GO:0019525 ! keto-D-gluconate metabolic process
is_a: GO:0046181 ! ketogluconate catabolic process

[Term]
id: GO:0019525
name: keto-D-gluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732]
synonym: "keto-D-gluconate metabolism" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process

[Term]
id: GO:0019526
name: pentitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
synonym: "pentitol anabolism" EXACT []
synonym: "pentitol biosynthesis" EXACT []
synonym: "pentitol formation" EXACT []
synonym: "pentitol synthesis" EXACT []
is_a: GO:0019401 ! alditol biosynthetic process
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019527
name: pentitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
synonym: "pentitol breakdown" EXACT []
synonym: "pentitol catabolism" EXACT []
synonym: "pentitol degradation" EXACT []
is_a: GO:0019405 ! alditol catabolic process
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019528
name: D-arabitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY]
synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "D-arabitol degradation" RELATED []
synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT []
synonym: "D-arabitol utilization" RELATED []
xref: MetaCyc:DARABITOLUTIL-PWY
is_a: GO:0051159 ! D-arabitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019529
name: taurine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
synonym: "taurine breakdown" EXACT []
synonym: "taurine catabolism" EXACT []
synonym: "taurine degradation" EXACT []
xref: MetaCyc:TAURINEDEG-PWY
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0046306 ! alkanesulfonate catabolic process

[Term]
id: GO:0019530
name: taurine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
synonym: "taurine metabolism" EXACT []
is_a: GO:0019694 ! alkanesulfonate metabolic process

[Term]
id: GO:0019531
name: oxalate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
synonym: "oxalic acid transporter activity" EXACT []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0019532
name: oxalate transport
namespace: biological_process
def: "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
synonym: "ethanedioate transport" EXACT []
synonym: "ethanedioic acid transport" EXACT []
synonym: "oxalic acid transport" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0019533
name: cellobiose transport
namespace: biological_process
def: "The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai]
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0019534
name: toxin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0019535
name: ferric-vibriobactin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015603 ! iron chelate transmembrane transporter activity

[Term]
id: GO:0019536
name: vibriobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537]
synonym: "vibriobactin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0019537
name: vibriobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031195
alt_id: GO:0031196
def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537]
synonym: "vibriobactin anabolism" EXACT []
synonym: "vibriobactin biosynthesis" EXACT []
synonym: "vibriobactin biosynthetic process, peptide formation" NARROW []
synonym: "vibriobactin biosynthetic process, peptide modification" NARROW []
synonym: "vibriobactin formation" EXACT []
synonym: "vibriobactin synthesis" EXACT []
is_a: GO:0019536 ! vibriobactin metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0019538
name: protein metabolic process
namespace: biological_process
alt_id: GO:0006411
alt_id: GO:0044267
alt_id: GO:0044268
def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cellular protein metabolic process" EXACT []
synonym: "cellular protein metabolism" EXACT []
synonym: "multicellular organismal protein metabolic process" NARROW []
synonym: "protein metabolic process and modification" EXACT []
synonym: "protein metabolism" EXACT []
synonym: "protein metabolism and modification" EXACT []
xref: Wikipedia:Protein_metabolism
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0019539
name: hydroxymate-containing siderophore biosynthetic process
namespace: biological_process
alt_id: GO:0031197
alt_id: GO:0031198
def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid. Hydroxamate is one of the three major chemical groups incorporated into siderophore structures with catechol and a-hydroxycarboxylate, each having a high selectivity for iron(3+)." [PMID:20376388]
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0019540
name: catechol-containing siderophore biosynthetic process
namespace: biological_process
alt_id: GO:0031189
alt_id: GO:0031190
def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol. Catechol is one of the three major chemical groups incorporated into siderophore structures with hydroxamate and a-hydroxycarboxylate, each having a high selectivity for iron(3+)." [PMID:20376388]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0019541
name: propionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732]
synonym: "propanoate metabolic process" EXACT []
synonym: "propanoate metabolism" EXACT []
synonym: "propionate metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019542
name: propionate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators]
synonym: "propionate anabolism" EXACT []
synonym: "propionate biosynthesis" EXACT []
synonym: "propionate formation" EXACT []
synonym: "propionate synthesis" EXACT []
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0019543
name: propionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators]
synonym: "propionate breakdown" EXACT []
synonym: "propionate catabolism" EXACT []
synonym: "propionate degradation" EXACT []
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019626 ! short-chain fatty acid catabolic process

[Term]
id: GO:0019544
name: arginine catabolic process to glutamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators]
synonym: "arginine breakdown to glutamate" EXACT []
synonym: "arginine degradation to glutamate" EXACT []
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006536 ! glutamate metabolic process

[Term]
id: GO:0019545
name: arginine catabolic process to succinate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators]
synonym: "arginine breakdown to succinate" EXACT []
synonym: "arginine degradation to succinate" EXACT []
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0019546
name: arginine deiminase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY]
xref: MetaCyc:ARGDEGRAD-PWY
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0019547
name: arginine catabolic process to ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators]
synonym: "arginine breakdown to ornithine" EXACT []
synonym: "arginine degradation to ornithine" EXACT []
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0019548
name: arginine catabolic process to spermine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators]
synonym: "arginine breakdown to spermine" EXACT []
synonym: "arginine degradation to spermine" EXACT []
xref: MetaCyc:ARGSPECAT-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0019549
name: obsolete glutamate catabolic process to succinate via succinate semialdehyde
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, GOC:go_curators, MetaCyc:PWY-4321]
comment: The reason for obsoletion is that this term was added in error (unnecessary specificity, these are steps in a single pathway)
is_obsolete: true
replaced_by: GO:0006540

[Term]
id: GO:0019550
name: glutamate catabolic process to aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators]
synonym: "glutamate breakdown to aspartate" EXACT []
synonym: "glutamate degradation to aspartate" EXACT []
xref: MetaCyc:GLUTDEG-PWY
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019551
name: obsolete glutamate catabolic process to 2-oxoglutarate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "glutamate breakdown to 2-oxoglutarate" EXACT []
synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT []
synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT []
synonym: "glutamate catabolism to 2-ketoglutarate" EXACT []
synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT []
synonym: "glutamate degradation to 2-oxoglutarate" EXACT []
is_obsolete: true

[Term]
id: GO:0019552
name: glutamate catabolic process via 2-hydroxyglutarate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY]
synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT []
xref: MetaCyc:P162-PWY
is_a: GO:0019670 ! anaerobic glutamate catabolic process

[Term]
id: GO:0019553
name: glutamate catabolic process via L-citramalate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators]
synonym: "glutamate breakdown via L-citramalate" EXACT []
synonym: "glutamate degradation via L-citramalate" EXACT []
xref: MetaCyc:GLUDEG-II-PWY
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019554
name: glutamate catabolic process to oxaloacetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators]
synonym: "glutamate breakdown to oxaloacetate" EXACT []
synonym: "glutamate degradation to oxaloacetate" EXACT []
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019555
name: glutamate catabolic process to ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators]
synonym: "glutamate breakdown to ornithine" EXACT []
synonym: "glutamate degradation to ornithine" EXACT []
xref: MetaCyc:GLUTORN-PWY
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0019556
name: L-histidine catabolic process to glutamate and formamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide." [GOC:go_curators]
synonym: "histidine breakdown to glutamate and formamide" EXACT []
synonym: "histidine catabolic process to glutamate and formamide" BROAD []
synonym: "histidine degradation to glutamate and formamide" EXACT []
xref: MetaCyc:HISDEG-PWY
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006548 ! L-histidine catabolic process
is_a: GO:0043605 ! amide catabolic process
is_a: GO:0043606 ! formamide metabolic process

[Term]
id: GO:0019557
name: L-histidine catabolic process to glutamate and formate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate." [GOC:go_curators]
synonym: "histidine breakdown to glutamate and formate" EXACT []
synonym: "histidine catabolic process to glutamate and formate" BROAD []
synonym: "histidine degradation to glutamate and formate" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006548 ! L-histidine catabolic process
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0019558
name: L-histidine catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators]
synonym: "histidine breakdown to 2-oxoglutarate" EXACT []
synonym: "histidine catabolic process to 2-ketoglutarate" EXACT []
synonym: "histidine catabolic process to 2-oxoglutarate" BROAD []
synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT []
synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT []
synonym: "histidine catabolism to 2-ketoglutarate" EXACT []
synonym: "histidine catabolism to alpha-ketoglutarate" EXACT []
synonym: "histidine catabolism to alpha-oxoglutarate" EXACT []
synonym: "histidine degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006548 ! L-histidine catabolic process

[Term]
id: GO:0019559
name: histidine catabolic process to imidazol-5-yl-lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators]
synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT []
synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT []
xref: MetaCyc:HISTDEG-PWY
is_a: GO:0006548 ! L-histidine catabolic process

[Term]
id: GO:0019560
name: histidine catabolic process to hydantoin-5-propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators]
synonym: "histidine breakdown to hydantoin-5-propionate" EXACT []
synonym: "histidine degradation to hydantoin-5-propionate" EXACT []
xref: MetaCyc:HISHP-PWY
is_a: GO:0006548 ! L-histidine catabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019561
name: anaerobic phenylalanine oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY]
xref: MetaCyc:ANAPHENOXI-PWY
is_a: GO:0006559 ! L-phenylalanine catabolic process

[Term]
id: GO:0019562
name: obsolete L-phenylalanine catabolic process to phosphoenolpyruvate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators]
comment: The reason for obsoletion is that there is no evidence that this is a real process.
synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT []
synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT []
is_obsolete: true

[Term]
id: GO:0019563
name: glycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732]
synonym: "glycerol breakdown" EXACT []
synonym: "glycerol catabolism" EXACT []
synonym: "glycerol degradation" EXACT []
xref: MetaCyc:GLYCEROL-DEG
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0019405 ! alditol catabolic process

[Term]
id: GO:0019564
name: aerobic glycerol catabolic process
namespace: biological_process
alt_id: GO:0019565
def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732]
synonym: "aerobic glycerol breakdown" EXACT []
synonym: "aerobic glycerol catabolism" EXACT []
synonym: "aerobic glycerol degradation" EXACT []
synonym: "aerobic glycerol fermentation" RELATED []
xref: MetaCyc:PWY0-381
is_a: GO:0019563 ! glycerol catabolic process

[Term]
id: GO:0019566
name: arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732]
synonym: "arabinose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0019567
name: arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai]
synonym: "arabinose anabolism" EXACT []
synonym: "arabinose biosynthesis" EXACT []
synonym: "arabinose formation" EXACT []
synonym: "arabinose synthesis" EXACT []
is_a: GO:0019322 ! pentose biosynthetic process
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0019568
name: arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai]
synonym: "arabinose breakdown" EXACT []
synonym: "arabinose catabolism" EXACT []
synonym: "arabinose degradation" EXACT []
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0019569
name: L-arabinose catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators]
synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT []
xref: MetaCyc:ARABCAT-PWY
is_a: GO:0019572 ! L-arabinose catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019570
name: L-arabinose catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators]
synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT []
synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT []
synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT []
synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT []
synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT []
synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT []
synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT []
synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0019572 ! L-arabinose catabolic process

[Term]
id: GO:0019571
name: D-arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose." [GOC:jsg, GOC:mah]
synonym: "D-arabinose breakdown" EXACT []
synonym: "D-arabinose catabolism" EXACT []
synonym: "D-arabinose degradation" EXACT []
is_a: GO:0019568 ! arabinose catabolic process
is_a: GO:0046372 ! D-arabinose metabolic process

[Term]
id: GO:0019572
name: L-arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose." [GOC:jsg, GOC:mah]
synonym: "L-arabinose breakdown" EXACT []
synonym: "L-arabinose catabolism" EXACT []
synonym: "L-arabinose degradation" EXACT []
is_a: GO:0019568 ! arabinose catabolic process
is_a: GO:0046373 ! L-arabinose metabolic process

[Term]
id: GO:0019573
name: D-arabinose catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators]
synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT []
synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT []
xref: MetaCyc:DARABCAT-PWY
is_a: GO:0019571 ! D-arabinose catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019574
name: sucrose catabolic process via 3'-ketosucrose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3'-ketosucrose. 3'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose." [GOC:bf, GOC:dgf, MetaCyc:SUCROSEUTIL2-PWY]
synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT []
synonym: "sucrose catabolic process to D-glucose" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY]
synonym: "sucrose catabolic process, using glucoside 3-dehydrogenase" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY]
synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT []
synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT []
xref: MetaCyc:SUCROSEUTIL2-PWY
is_a: GO:0005987 ! sucrose catabolic process
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019575
name: obsolete sucrose catabolic process, using beta-fructofuranosidase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl]
comment: This term was made obsolete because beta-fructofuranosidase (also known as invertase) catalyzes the first step in multiple routes of sucrose catabolism.
synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT []
synonym: "sucrose catabolic process, using beta-fructofuranosidase" EXACT []
synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT []
synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT []
is_obsolete: true
consider: GO:0004564
consider: GO:0036008

[Term]
id: GO:0019576
name: obsolete aerobic fructose catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai]
comment: The reason for obsoletion is that this term is not clearly defined the meaning is ambiguous.
synonym: "aerobic fructose breakdown" EXACT []
synonym: "aerobic fructose catabolism" EXACT []
synonym: "aerobic fructose degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0019577
name: aldaric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732]
synonym: "aldaric acid metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0019578
name: aldaric acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732]
synonym: "aldaric acid anabolism" EXACT []
synonym: "aldaric acid biosynthesis" EXACT []
synonym: "aldaric acid formation" EXACT []
synonym: "aldaric acid synthesis" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019579
name: aldaric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732]
synonym: "aldaric acid breakdown" EXACT []
synonym: "aldaric acid catabolism" EXACT []
synonym: "aldaric acid degradation" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0019580
name: galactarate metabolic process
namespace: biological_process
alt_id: GO:0046393
def: "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [GOC:pr, ISBN:0198506732]
synonym: "D-galactarate metabolic process" RELATED []
synonym: "D-galactarate metabolism" RELATED []
synonym: "galactarate metabolism" EXACT []
synonym: "mucic acid metabolic process" EXACT []
synonym: "mucic acid metabolism" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process

[Term]
id: GO:0019583
name: galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai]
synonym: "galactonate metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019584
name: galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai]
synonym: "galactonate breakdown" EXACT []
synonym: "galactonate catabolism" EXACT []
synonym: "galactonate degradation" EXACT []
is_a: GO:0019583 ! galactonate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0019585
name: glucuronate metabolic process
namespace: biological_process
alt_id: GO:0019699
def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732]
synonym: "glucuronate metabolism" EXACT []
xref: Wikipedia:Glucuronic_acid
is_a: GO:0006063 ! uronic acid metabolic process

[Term]
id: GO:0019586
name: galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732]
synonym: "galacturonate metabolism" EXACT []
is_a: GO:0006063 ! uronic acid metabolic process

[Term]
id: GO:0019588
name: anaerobic glycerol catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah]
synonym: "glycerol fermentation" EXACT []
is_a: GO:0019563 ! glycerol catabolic process
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019589
name: anaerobic glycerol catabolic process to propane-1,3-diol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY]
synonym: "glycerol fermentation to 1,3-propanediol" EXACT []
synonym: "glycerol fermentation to propane-1,3-diol" EXACT []
xref: MetaCyc:GOLPDLCAT-PWY
is_a: GO:0019588 ! anaerobic glycerol catabolic process
is_a: GO:0051143 ! propanediol metabolic process

[Term]
id: GO:0019590
name: L-arabitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [GOC:curators]
synonym: "L-arabitol and xylitol degradation" BROAD []
synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT []
synonym: "L-arabitol utilization" RELATED []
is_a: GO:0051158 ! L-arabitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019592
name: mannitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "mannitol breakdown" EXACT []
synonym: "mannitol catabolism" EXACT []
synonym: "mannitol degradation" EXACT []
is_a: GO:0019407 ! hexitol catabolic process
is_a: GO:0019594 ! mannitol metabolic process

[Term]
id: GO:0019593
name: mannitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "mannitol anabolism" EXACT []
synonym: "mannitol biosynthesis" EXACT []
synonym: "mannitol formation" EXACT []
synonym: "mannitol synthesis" EXACT []
xref: MetaCyc:PWY-3881
is_a: GO:0019406 ! hexitol biosynthetic process
is_a: GO:0019594 ! mannitol metabolic process

[Term]
id: GO:0019594
name: mannitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "mannitol metabolism" EXACT []
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0019595
name: non-phosphorylated glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai]
synonym: "non-phosphorylated glucose breakdown" EXACT []
synonym: "non-phosphorylated glucose catabolism" EXACT []
synonym: "non-phosphorylated glucose degradation" EXACT []
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0046430 ! non-phosphorylated glucose metabolic process

[Term]
id: GO:0019596
name: mandelate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators]
synonym: "mandelate breakdown" EXACT []
synonym: "mandelate catabolism" EXACT []
synonym: "mandelate degradation" EXACT []
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0019597
name: (R)-mandelate catabolic process to benzoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators]
synonym: "(R)-mandelate breakdown to benzoate" EXACT []
synonym: "(R)-mandelate degradation to benzoate" EXACT []
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0019596 ! mandelate catabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0019598
name: (R)-mandelate catabolic process to catechol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators]
synonym: "(R)-mandelate breakdown to catechol" EXACT []
synonym: "(R)-mandelate degradation to catechol" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0019596 ! mandelate catabolic process

[Term]
id: GO:0019599
name: (R)-4-hydroxymandelate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai]
synonym: "(R)-4-hydroxymandelate breakdown" EXACT []
synonym: "(R)-4-hydroxymandelate catabolism" EXACT []
synonym: "(R)-4-hydroxymandelate degradation" EXACT []
xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019600
name: toluene oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene." [GOC:mah]
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0019601
name: toluene oxidation via 2-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY]
xref: MetaCyc:TOLUENE-DEG-2-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019602
name: toluene oxidation via 3-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY]
xref: MetaCyc:TOLUENE-DEG-3-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019603
name: toluene oxidation via 4-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY]
xref: MetaCyc:TOLUENE-DEG-4-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019604
name: toluene oxidation to catechol
namespace: biological_process
def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY]
xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY
xref: UM-BBD_pathwayID:tol
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019605
name: butyrate metabolic process
namespace: biological_process
alt_id: GO:0043437
def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732]
synonym: "butanoic acid metabolic process" EXACT []
synonym: "butanoic acid metabolism" EXACT []
synonym: "butyrate metabolism" EXACT []
synonym: "butyric acid metabolic process" EXACT []
synonym: "butyric acid metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019606
name: 2-oxobutyrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732]
synonym: "2-oxobutyrate breakdown" EXACT []
synonym: "2-oxobutyrate catabolism" EXACT []
synonym: "2-oxobutyrate degradation" EXACT []
synonym: "alpha-ketobutyrate catabolic process" EXACT []
synonym: "alpha-ketobutyrate catabolism" EXACT []
xref: MetaCyc:2OXOBUTYRATECAT-PWY
is_a: GO:0019626 ! short-chain fatty acid catabolic process
is_a: GO:0046361 ! 2-oxobutyrate metabolic process

[Term]
id: GO:0019607
name: phenylethylamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine breakdown" EXACT []
synonym: "phenylethylamine catabolism" EXACT []
synonym: "phenylethylamine degradation" EXACT []
xref: MetaCyc:2PHENDEG-PWY
is_a: GO:0042402 ! biogenic amine catabolic process
is_a: GO:0042443 ! phenylethylamine metabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0019608
name: nicotine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
synonym: "nicotine breakdown" EXACT []
synonym: "nicotine catabolism" EXACT []
synonym: "nicotine degradation" EXACT []
xref: MetaCyc:P181-PWY
xref: UM-BBD_pathwayID:nic
is_a: GO:0009056 ! catabolic process
is_a: GO:0018933 ! nicotine metabolic process

[Term]
id: GO:0019609
name: 3-hydroxyphenylacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [PMID:6995433]
synonym: "3-hydroxyphenylacetate metabolism" EXACT []
synonym: "3HPA metabolic process" EXACT []
synonym: "3HPA metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019610
name: 3-hydroxyphenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [PMID:6995433]
synonym: "3-hydroxyphenylacetate breakdown" EXACT []
synonym: "3-hydroxyphenylacetate catabolism" EXACT []
synonym: "3-hydroxyphenylacetate degradation" EXACT []
xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019611
name: 4-toluenecarboxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
synonym: "4-toluenecarboxylate metabolism" EXACT []
synonym: "p-toluate metabolic process" EXACT []
synonym: "p-toluate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0019612
name: 4-toluenecarboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
synonym: "4-toluenecarboxylate breakdown" EXACT []
synonym: "4-toluenecarboxylate catabolism" EXACT []
synonym: "4-toluenecarboxylate degradation" EXACT []
synonym: "p-toluate catabolic process" EXACT []
synonym: "p-toluate catabolism" EXACT []
xref: MetaCyc:4TOLCARBDEG-PWY
is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019614
name: catechol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
synonym: "catechol breakdown" RELATED []
synonym: "catechol catabolic process" RELATED []
synonym: "catechol catabolism" RELATED []
synonym: "catechol degradation" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process

[Term]
id: GO:0019615
name: catechol catabolic process, ortho-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, PMID:7765833]
synonym: "catechol breakdown, ortho-cleavage" EXACT []
synonym: "catechol degradation, ortho-cleavage" EXACT []
xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0042952 ! beta-ketoadipate pathway

[Term]
id: GO:0019616
name: catechol catabolic process, meta-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, PMID:7765833]
synonym: "catechol breakdown, meta-cleavage" EXACT []
synonym: "catechol degradation, meta-cleavage" EXACT []
xref: MetaCyc:P183-PWY
is_a: GO:0019614 ! catechol-containing compound catabolic process

[Term]
id: GO:0019617
name: protocatechuate catabolic process, meta-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY]
synonym: "3,4-dihydroxybenzoate catabolic process, meta-cleavage" RELATED []
synonym: "protocatechuate breakdown, meta-cleavage" EXACT []
synonym: "protocatechuate catabolic process to oxaloacetate and pyruvate" EXACT []
synonym: "protocatechuate degradation, meta-cleavage" EXACT []
xref: MetaCyc:P184-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process

[Term]
id: GO:0019618
name: protocatechuate catabolic process, ortho-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY]
synonym: "3,4-dihydroxybenzoate catabolic process, ortho-cleavage" EXACT []
synonym: "protocatechuate breakdown, ortho-cleavage" EXACT []
synonym: "protocatechuate catabolic process to beta-ketoadipate" EXACT []
synonym: "protocatechuate degradation, ortho-cleavage" EXACT []
xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY
is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:0019619
name: 3,4-dihydroxybenzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate." [GOC:ai]
synonym: "protocatechuate breakdown" EXACT []
synonym: "protocatechuate catabolic process" EXACT []
synonym: "protocatechuate catabolism" EXACT []
synonym: "protocatechuate degradation" EXACT []
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019620
name: aerobic benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai]
synonym: "aerobic benzoate metabolism" EXACT []
is_a: GO:0018874 ! benzoate metabolic process

[Term]
id: GO:0019621
name: creatinine catabolic process to formate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators]
synonym: "creatinine breakdown to formate" EXACT []
synonym: "creatinine degradation to formate" EXACT []
xref: MetaCyc:CRNFORCAT-PWY
is_a: GO:0006602 ! creatinine catabolic process
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0019622
name: 3-(3-hydroxy)phenylpropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai]
synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT []
synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT []
synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT []
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019623
name: atrazine catabolic process to urea
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl]
synonym: "atrazine breakdown to urea" EXACT []
synonym: "atrazine degradation to urea" EXACT []
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043605 ! amide catabolic process

[Term]
id: GO:0019624
name: atrazine catabolic process to isopropylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl]
synonym: "atrazine breakdown to isopropylamine" EXACT []
synonym: "atrazine degradation to isopropylamine" EXACT []
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0019625
name: atrazine catabolic process to cyanuric acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl]
synonym: "atrazine breakdown to cyanuric acid" EXACT []
synonym: "atrazine degradation to cyanuric acid" EXACT []
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:0042199 ! cyanuric acid metabolic process

[Term]
id: GO:0019626
name: short-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [ISBN:0198506732]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "short-chain fatty acid breakdown" EXACT []
synonym: "short-chain fatty acid catabolism" EXACT []
synonym: "short-chain fatty acid degradation" EXACT []
xref: MetaCyc:ACETOACETATE-DEG-PWY
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019627
name: urea metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2." [ISBN:0198506732]
synonym: "urea metabolism" EXACT []
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0019628
name: urate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732]
synonym: "urate breakdown" EXACT []
synonym: "urate catabolism" EXACT []
synonym: "urate degradation" EXACT []
synonym: "uric acid catabolic process" EXACT []
xref: MetaCyc:P165-PWY
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046415 ! urate metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0019629
name: propionate catabolic process, 2-methylcitrate cycle
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators]
synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT []
synonym: "propionate degradation, 2-methylcitrate cycle" EXACT []
is_a: GO:0019543 ! propionate catabolic process

[Term]
id: GO:0019630
name: quinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732]
synonym: "quinate metabolism" EXACT []
synonym: "quinic acid metabolic process" EXACT []
synonym: "quinic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019631
name: quinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl]
synonym: "quinate breakdown" EXACT []
synonym: "quinate catabolism" EXACT []
synonym: "quinate degradation" EXACT []
synonym: "quinic acid catabolic process" EXACT []
synonym: "quinic acid catabolism" EXACT []
xref: MetaCyc:QUINATEDEG-PWY
is_a: GO:0019630 ! quinate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019632
name: shikimate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:sm, ISBN:0198547684]
synonym: "shikimate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0019633
name: shikimate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [GOC:go_curators]
synonym: "shikimate breakdown" EXACT []
synonym: "shikimate catabolism" EXACT []
synonym: "shikimate degradation" EXACT []
xref: MetaCyc:SHIKIMATEDEG-PWY
is_a: GO:0019632 ! shikimate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0019634
name: organic phosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544]
synonym: "organophosphonate metabolic process" RELATED []
synonym: "phosphonate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0019635
name: 2-aminoethylphosphonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai]
synonym: "2-aminoethylphosphonate breakdown" EXACT []
synonym: "2-aminoethylphosphonate catabolism" EXACT []
synonym: "2-aminoethylphosphonate degradation" EXACT []
synonym: "2-phosphonoethylamine catabolic process" EXACT []
synonym: "2-phosphonoethylamine catabolism" EXACT []
synonym: "ciliatine catabolic process" EXACT []
synonym: "ciliatine catabolism" EXACT []
xref: MetaCyc:PHOSPHONOTASE-PWY
is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0019636
name: phosphonoacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY]
synonym: "phosphonoacetate metabolism" EXACT []
xref: MetaCyc:P483-PWY
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019637
name: organophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]
subset: goslim_pombe
synonym: "organophosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0019638
name: 6-hydroxycineole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
synonym: "6-endo-hydroxycineole metabolic process" EXACT []
synonym: "6-endo-hydroxycineole metabolism" EXACT []
synonym: "6-hydroxycineole metabolism" EXACT []
synonym: "hydroxycineol metabolic process" EXACT []
synonym: "hydroxycineol metabolism" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0097176 ! epoxide metabolic process

[Term]
id: GO:0019639
name: 6-hydroxycineole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
synonym: "6-endo-hydroxycineole catabolic process" EXACT []
synonym: "6-endo-hydroxycineole catabolism" EXACT []
synonym: "6-hydroxycineole breakdown" EXACT []
synonym: "6-hydroxycineole catabolism" EXACT []
synonym: "6-hydroxycineole degradation" EXACT []
synonym: "hydroxycineol catabolic process" EXACT []
synonym: "hydroxycineol catabolism" EXACT []
xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0019638 ! 6-hydroxycineole metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0019640
name: D-glucuronate catabolic process to D-xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate into D-xylulose 5-phosphate." [GOC:go_curators, PMID:27189775]
synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT []
synonym: "glucuronate catabolic process to xylulose 5-phosphate" EXACT []
synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT []
is_a: GO:0042840 ! D-glucuronate catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019643
name: reductive tricarboxylic acid cycle
namespace: biological_process
alt_id: GO:0019644
def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028]
synonym: "reductive carboxylate cycle" EXACT []
synonym: "reductive carboxylic acid cycle" EXACT []
synonym: "reductive citric acid pathway" EXACT []
synonym: "reductive Kreb's cycle" EXACT []
synonym: "reductive TCA cycle" EXACT []
is_a: GO:0015977 ! carbon fixation

[Term]
id: GO:0019645
name: anaerobic electron transport chain
namespace: biological_process
def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0009061 ! anaerobic respiration

[Term]
id: GO:0019646
name: aerobic electron transport chain
namespace: biological_process
alt_id: GO:0006136
alt_id: GO:0006137
alt_id: GO:0006138
def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]
synonym: "NADH-O2 electron transport" NARROW []
synonym: "succinate-O2 electron transport" NARROW []
synonym: "ubiquinone-8-O2 electron transport" NARROW []
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0019647
name: formaldehyde assimilation via ribulose monophosphate cycle
namespace: biological_process
def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861]
synonym: "formaldehyde assimilation via RuMP cycle" EXACT []
synonym: "ribulose monophosphate cycle" BROAD []
xref: MetaCyc:PWY-1861
is_a: GO:0019649 ! formaldehyde assimilation

[Term]
id: GO:0019648
name: formaldehyde assimilation via xylulose monophosphate cycle
namespace: biological_process
def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY]
synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT []
synonym: "formaldehyde fixation cycle" EXACT []
xref: MetaCyc:P185-PWY
is_a: GO:0019649 ! formaldehyde assimilation
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019649
name: formaldehyde assimilation
namespace: biological_process
def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai]
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0019650
name: glycolytic fermentation to butanediol
namespace: biological_process
alt_id: GO:0030646
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [GOC:dph, GOC:nr, ISBN:0198506732]
synonym: "butanediol fermentation" EXACT []
synonym: "glucose catabolic process to butanediol" EXACT [GOC:dph]
synonym: "glucose fermentation to butanediol" EXACT []
xref: Wikipedia:Butanediol_fermentation
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019660 ! glycolytic fermentation
is_a: GO:0034077 ! butanediol metabolic process

[Term]
id: GO:0019651
name: citrate catabolic process to diacetyl
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY]
synonym: "citrate fermentation to diacetyl" EXACT []
synonym: "diacetyl fermentation" EXACT []
is_a: GO:0006101 ! citrate metabolic process
is_a: GO:0019662 ! non-glycolytic fermentation
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process

[Term]
id: GO:0019652
name: lactate fermentation to propionate and acetate
namespace: biological_process
def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY]
synonym: "acrylate pathway" EXACT []
synonym: "nonrandomizing pathway" EXACT []
synonym: "propionate fermentation" EXACT []
xref: MetaCyc:PROPFERM-PWY
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019653
name: anaerobic purine nucleobase catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP." [GOC:mah]
synonym: "anaerobic purine base catabolic process" EXACT [GOC:go_curators]
synonym: "anaerobic purine base catabolism" EXACT []
synonym: "anaerobic purine catabolic process" RELATED []
synonym: "purine base fermentation" EXACT []
synonym: "purine fermentation" RELATED []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation

[Term]
id: GO:0019654
name: acetate fermentation
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [GOC:jl, MetaCyc:P142-PWY]
xref: MetaCyc:P142-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019655
name: glycolytic fermentation to ethanol
namespace: biological_process
alt_id: GO:0043458
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [GOC:dph, GOC:nr, ISBN:0716720094]
synonym: "alcoholic fermentation" RELATED [ISBN:0716720094]
synonym: "ethanol anabolism during fermentation" RELATED []
synonym: "ethanol biosynthetic process involved in glucose fermentation to ethanol" RELATED []
synonym: "ethanol fermentation" EXACT []
synonym: "ethanol formation during fermentation" RELATED []
synonym: "ethanol synthesis during fermentation" RELATED []
synonym: "glucose catabolic process to ethanol" EXACT [GOC:dph]
synonym: "glucose fermentation to ethanol" EXACT []
xref: Wikipedia:Ethanol_fermentation
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019656
name: glucose catabolic process to D-lactate and ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY]
synonym: "glucose fermentation to D-lactate and ethanol" EXACT []
synonym: "heterofermentation" EXACT []
synonym: "heterofermentative lactate fermentation" EXACT []
synonym: "heterofermentative pathway" EXACT []
synonym: "heterolactate fermentation" EXACT []
synonym: "heterolactic fermentation" EXACT []
xref: MetaCyc:P122-PWY
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019657
name: glycolytic fermentation to propionate
namespace: biological_process
def: "Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [GOC:dph, GOC:nr, MetaCyc:P108-PWY]
synonym: "succinate-propionate fermentation" EXACT []
xref: MetaCyc:P108-PWY
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019660 ! glycolytic fermentation
is_a: GO:0042867 ! pyruvate catabolic process

[Term]
id: GO:0019658
name: glucose fermentation to lactate and acetate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY]
synonym: "bifidum pathway" EXACT []
synonym: "glucose catabolic process to lactate and acetate" BROAD []
xref: MetaCyc:P124-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019659
name: glucose catabolic process to lactate
namespace: biological_process
def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
synonym: "glucose fermentation to lactate" EXACT []
synonym: "lactate fermentation" EXACT []
xref: Wikipedia:Lactic_acid_fermentation
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019660
name: glycolytic fermentation
namespace: biological_process
def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:curators]
xref: MetaCyc:Pyruvate-Degradation
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019661
name: glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
synonym: "glucose fermentation to lactate via pyruvate" EXACT []
synonym: "homofermentation" EXACT []
synonym: "homofermentative lactate fermentation" EXACT []
synonym: "homofermentative pathway" EXACT []
synonym: "homolactate fermentation" EXACT []
synonym: "homolactic fermentation" EXACT [ISBN:0716720094]
xref: MetaCyc:ANAEROFRUCAT-PWY
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019662
name: non-glycolytic fermentation
namespace: biological_process
def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl]
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019664
name: mixed acid fermentation
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [ISBN:0716720094, MetaCyc:FERMENTATION-PWY]
synonym: "glucose catabolic process to mixed acids" BROAD []
synonym: "glucose fermentation to mixed acids" EXACT []
xref: MetaCyc:FERMENTATION-PWY
xref: Wikipedia:Mixed_acid_fermentation
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019665
name: anaerobic amino acid catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl]
synonym: "amino acid fermentation" EXACT []
is_a: GO:0006113 ! fermentation
is_a: GO:0009063 ! amino acid catabolic process

[Term]
id: GO:0019666
name: nitrogenous compound fermentation
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah]
synonym: "nitrogenous compound catabolic process" BROAD []
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019667
name: anaerobic L-alanine catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl]
synonym: "L-alanine fermentation" EXACT []
is_a: GO:0019665 ! anaerobic amino acid catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019668
name: anaerobic catabolism of pairs of amino acids
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081]
synonym: "cofermentation of pairs of amino acids" EXACT []
synonym: "Stickland reaction" NARROW []
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019669
name: anaerobic glycine catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl]
synonym: "glycine fermentation" EXACT []
is_a: GO:0006546 ! glycine catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation

[Term]
id: GO:0019670
name: anaerobic glutamate catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl]
synonym: "glutamate fermentation" EXACT []
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation

[Term]
id: GO:0019671
name: obsolete glutamate catabolic process via mesaconate and citramalate
namespace: biological_process
def: "OBSOLETE. The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [GOC:rynl]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "glutamate fermentation via mesaconate and citramalate" EXACT []
is_obsolete: true
consider: GO:0019553
consider: GO:0033508
consider: GO:0033509

[Term]
id: GO:0019672
name: ethanol-acetate fermentation to butyrate and caproate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY]
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019673
name: GDP-mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-mannose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0019674
name: NAD metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
synonym: "NAD (oxidized) metabolic process" EXACT []
synonym: "NAD (oxidized) metabolism" EXACT []
synonym: "NAD metabolism" EXACT []
synonym: "NAD phosphorylation and dephosphorylation" NARROW []
synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide metabolism" EXACT []
synonym: "oxidized NAD metabolic process" EXACT []
synonym: "oxidized NAD metabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0019675
name: obsolete NAD phosphorylation and dephosphorylation
namespace: biological_process
def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist.
synonym: "NAD phosphorylation and dephosphorylation" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT []
is_obsolete: true
consider: GO:0006739
consider: GO:0019674

[Term]
id: GO:0019676
name: ammonia assimilation cycle
namespace: biological_process
def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY]
synonym: "glutamate metabolic process via glutamine and ammonia" EXACT []
synonym: "glutamate metabolism via glutamine and ammonia" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0019740 ! nitrogen utilization

[Term]
id: GO:0019677
name: NAD catabolic process
namespace: biological_process
alt_id: GO:0006737
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]
synonym: "NAD (oxidized) catabolic process" EXACT []
synonym: "NAD (oxidized) catabolism" EXACT []
synonym: "NAD (reduced) catabolic process" EXACT []
synonym: "NAD (reduced) catabolism" EXACT []
synonym: "NAD breakdown" EXACT []
synonym: "NAD catabolism" EXACT []
synonym: "NAD degradation" EXACT []
synonym: "NADH catabolic process" EXACT []
synonym: "NADH catabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide catabolism" EXACT []
synonym: "oxidized NAD catabolic process" EXACT []
synonym: "oxidized NAD catabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT []
synonym: "reduced NAD catabolic process" EXACT []
synonym: "reduced NAD catabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0019364 ! pyridine nucleotide catabolic process
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0019678
name: propionate metabolic process, methylmalonyl pathway
namespace: biological_process
def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators]
synonym: "propionate metabolism, methylmalonyl pathway" EXACT []
xref: MetaCyc:PROPIONMET-PWY
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0019679
name: propionate metabolic process, methylcitrate cycle
namespace: biological_process
def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators]
synonym: "propionate metabolism, methylcitrate cycle" EXACT []
xref: MetaCyc:PWY0-42
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0019680
name: L-methylmalonyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-methylmalonyl-CoA anabolism" EXACT []
synonym: "L-methylmalonyl-CoA biosynthesis" EXACT []
synonym: "L-methylmalonyl-CoA formation" EXACT []
synonym: "L-methylmalonyl-CoA synthesis" EXACT []
xref: MetaCyc:PWY0-43
is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0019681
name: acetyl-CoA assimilation pathway
namespace: biological_process
def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY]
synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0046356 ! acetyl-CoA catabolic process

[Term]
id: GO:0019682
name: glyceraldehyde-3-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732]
synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT []
synonym: "glyceraldehyde 3-phosphate metabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019683
name: glyceraldehyde-3-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732]
synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT []
synonym: "glyceraldehyde 3-phosphate catabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate breakdown" EXACT []
synonym: "glyceraldehyde-3-phosphate catabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate degradation" EXACT []
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0019684
name: photosynthesis, light reaction
namespace: biological_process
def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [PMID:15746074]
synonym: "photolysis" RELATED []
xref: MetaCyc:PWY-101
xref: Wikipedia:Photolysis#Photolysis_in_photosynthesis
is_a: GO:0006091 ! generation of precursor metabolites and energy
relationship: part_of GO:0015979 ! photosynthesis

[Term]
id: GO:0019685
name: photosynthesis, dark reaction
namespace: biological_process
def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952]
is_a: GO:0016051 ! carbohydrate biosynthetic process
relationship: part_of GO:0015979 ! photosynthesis

[Term]
id: GO:0019686
name: purine nucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0019687
name: pyruvate biosynthetic process from acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators]
synonym: "pyruvate anabolism from acetate" EXACT []
synonym: "pyruvate formation from acetate" EXACT []
synonym: "pyruvate synthesis from acetate" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0042866 ! pyruvate biosynthetic process

[Term]
id: GO:0019688
name: purine deoxyribonucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0019686 ! purine nucleoside interconversion
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0019689
name: pyrimidine nucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion

[Term]
id: GO:0019690
name: pyrimidine deoxyribonucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
is_a: GO:0019689 ! pyrimidine nucleoside interconversion
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0019692
name: deoxyribose phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732]
synonym: "deoxyribose phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019693
name: ribose phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]
synonym: "ribose phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019694
name: alkanesulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai]
synonym: "alkanesulfonate metabolism" EXACT []
synonym: "alkanesulphonate metabolic process" EXACT []
synonym: "alkanesulphonate metabolism" EXACT []
xref: MetaCyc:ALKANEMONOX-PWY
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0019695
name: choline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
synonym: "choline metabolism" EXACT []
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0019696
name: toluene oxidation via toluene-cis-1,2-dihydrodiol
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY]
xref: MetaCyc:TOLUENE-DEG-DIOL-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019697
name: L-xylitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY]
comment: Note that xylitol is a meso compound, thus there are no L or D-versions.
synonym: "L-arabitol and xylitol degradation" BROAD []
synonym: "xylitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "xylitol degradation to xylulose 5-phosphate" EXACT []
synonym: "xylitol utilization" RELATED []
xref: MetaCyc:LARABITOLUTIL-PWY
is_a: GO:0051160 ! xylitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019698
name: D-galacturonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "D-galacturonate breakdown" EXACT []
synonym: "D-galacturonate catabolism" EXACT []
synonym: "D-galacturonate degradation" EXACT []
xref: MetaCyc:GALACTUROCAT-PWY
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0046396 ! D-galacturonate metabolic process
is_a: GO:0046397 ! galacturonate catabolic process

[Term]
id: GO:0019700
name: organic phosphonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js]
synonym: "organophosphonate catabolic process" RELATED []
synonym: "phosphonate breakdown" EXACT []
synonym: "phosphonate catabolism" EXACT []
synonym: "phosphonate degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0019634 ! organic phosphonate metabolic process

[Term]
id: GO:0019701
name: obsolete peptidyl-arginine N5-methylation
namespace: biological_process
def: "OBSOLETE. The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-arginine delta-N-methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0019702
name: protein arginine N5-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine." [EC:2.1.1.322, PMID:11856739, PMID:9873020]
comment: This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the delta-nitrogen atom of arginine residues within proteins. Among its substrates are R67 of the ribosomal protein L12.
synonym: "protein arginine N5-methylase activity" EXACT []
synonym: "protein-arginine delta-N-methyltransferase activity" EXACT []
synonym: "protein-arginine N5-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)" RELATED [EC:2.1.1.322]
synonym: "type IV PRMT activity" EXACT []
synonym: "type IV protein arginine methyltransferase activity" EXACT []
xref: EC:2.1.1.322
xref: RHEA:48116
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0019703
name: obsolete coenzyme A-peptidyl-cysteine covalent linking
namespace: biological_process
def: "OBSOLETE. The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019704
name: obsolete peptidyl-L-cysteine S-myristoylation
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0019705
name: protein-cysteine S-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]." [GOC:ai, PMID:22247542, RHEA:59736]
xref: RHEA:59736
is_a: GO:0019107 ! myristoyltransferase activity
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0019706
name: protein-cysteine S-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]
synonym: "protein-cysteine S-palmitoleyltransferase activity" RELATED []
xref: EC:2.3.1.225
xref: Reactome:R-HSA-203567 "Palmitoylation of eNOS"
xref: Reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer"
xref: Reactome:R-HSA-9021072 "ZDHHC7, ZDHHC21 palmitoylate ESR1"
xref: Reactome:R-HSA-9647982 "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated"
xref: Reactome:R-HSA-9694341 "Spike protein gets palmitoylated"
xref: Reactome:R-HSA-9829047 "F0 is palmitoylated"
xref: Reactome:R-HSA-9830875 "G is palmitoylated"
xref: RHEA:36683
is_a: GO:0016409 ! palmitoyltransferase activity
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0019707
name: protein-cysteine S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai, RHEA:63372]
xref: RHEA:63372
is_a: GO:0016417 ! S-acyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0019708
name: obsolete peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
namespace: biological_process
def: "OBSOLETE. The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT []
is_obsolete: true

[Term]
id: GO:0019709
name: obsolete iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0019710
name: obsolete peptidyl-asparagine methylation
namespace: biological_process
alt_id: GO:0018018
def: "OBSOLETE. The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019711
name: obsolete peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT []
is_obsolete: true

[Term]
id: GO:0019712
name: obsolete peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid
namespace: biological_process
def: "OBSOLETE. The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT []
is_obsolete: true

[Term]
id: GO:0019713
name: obsolete peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine
namespace: biological_process
def: "OBSOLETE. The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT []
is_obsolete: true

[Term]
id: GO:0019714
name: obsolete peptidyl-glutamine esterification
namespace: biological_process
def: "OBSOLETE. The addition of an ester group to a glutamine residue in a protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019715
name: obsolete peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019716
name: obsolete N-terminal peptidyl-alanine monomethylation
namespace: biological_process
def: "OBSOLETE. The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019717
name: obsolete synaptosome
namespace: cellular_component
def: "OBSOLETE. Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a result of cell homogenization and not a bona fide cellular component.
synonym: "synaptosome" EXACT []
xref: Wikipedia:Synaptosome
is_obsolete: true
consider: GO:0043005

[Term]
id: GO:0019718
name: obsolete rough microsome
namespace: cellular_component
def: "OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "rough microsome" EXACT []
is_obsolete: true
consider: GO:0005791

[Term]
id: GO:0019719
name: obsolete smooth microsome
namespace: cellular_component
def: "OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "smooth microsome" EXACT []
is_obsolete: true
consider: GO:0005790

[Term]
id: GO:0019720
name: Mo-molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [PMID:23539623, PMID:35956883]
synonym: "Mo-molybdopterin cofactor metabolism" EXACT []
synonym: "Moco metabolic process" BROAD []
synonym: "Moco metabolism" BROAD []
is_a: GO:0043545 ! molybdopterin cofactor metabolic process

[Term]
id: GO:0019722
name: calcium-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]
synonym: "calcium ion signaling" EXACT []
synonym: "calcium signaling" EXACT []
synonym: "calcium signalling" EXACT []
synonym: "calcium-mediated signalling" EXACT []
xref: Wikipedia:Calcium_signaling
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0019724
name: B cell mediated immunity
namespace: biological_process
def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "B lymphocyte mediated immune effector process" EXACT []
synonym: "B lymphocyte mediated immunity" EXACT []
synonym: "B-cell mediated immune effector process" EXACT []
synonym: "B-cell mediated immunity" EXACT []
synonym: "B-lymphocyte mediated immune effector process" EXACT []
synonym: "B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0019725
name: cellular homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
subset: goslim_candida
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_plant
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0019726
name: obsolete mevaldate reductase (NADPH) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-mevalonate + NADP+ = H+ + mevaldate + NADPH." [EC:1.1.1.33, RHEA:20193]
comment: This term was obsoleted because the associated EC number has been deleted (EC 1.1.1.33), based on PMID:4463942 where the enzyme has been shown to actually belong to EC 1.1.1.2.
synonym: "(R)-mevalonate:NADP+ oxidoreductase" RELATED [EC:1.1.1.33]
synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" RELATED [EC:1.1.1.33]
is_obsolete: true
replaced_by: GO:0018455

[Term]
id: GO:0019727
name: obsolete mevaldate reductase (NADH) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-mevalonate + NAD+ = H+ + mevaldate + NADH." [GOC:curators]
comment: This term was obsoleted because it is believed to be a spontaneous reaction.
is_obsolete: true

[Term]
id: GO:0019728
name: obsolete peptidyl-allysine oxidation to 2-aminoadipic acid
namespace: biological_process
def: "OBSOLETE. The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019729
name: obsolete peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0189
is_obsolete: true

[Term]
id: GO:0019730
name: antimicrobial humoral response
namespace: biological_process
alt_id: GO:0006960
alt_id: GO:0019735
def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0006959 ! humoral immune response
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0019731
name: antibacterial humoral response
namespace: biological_process
alt_id: GO:0006961
alt_id: GO:0019733
def: "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0019730 ! antimicrobial humoral response
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0019732
name: antifungal humoral response
namespace: biological_process
alt_id: GO:0006966
alt_id: GO:0019734
def: "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0019730 ! antimicrobial humoral response
is_a: GO:0050832 ! defense response to fungus

[Term]
id: GO:0019736
name: obsolete peptidyl-sarcosine incorporation
namespace: biological_process
def: "OBSOLETE. The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019740
name: nitrogen utilization
namespace: biological_process
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0141067 ! intracellular nitrogen homeostasis

[Term]
id: GO:0019741
name: pentacyclic triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732]
synonym: "pentacyclic triterpenoid breakdown" EXACT []
synonym: "pentacyclic triterpenoid catabolism" EXACT []
synonym: "pentacyclic triterpenoid degradation" EXACT []
is_a: GO:0016105 ! triterpenoid catabolic process
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process

[Term]
id: GO:0019742
name: pentacyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732]
synonym: "pentacyclic triterpenoid metabolism" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process

[Term]
id: GO:0019743
name: hopanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
synonym: "hopanoid breakdown" EXACT []
synonym: "hopanoid catabolism" EXACT []
synonym: "hopanoid degradation" EXACT []
is_a: GO:0016105 ! triterpenoid catabolic process
is_a: GO:0019744 ! hopanoid metabolic process

[Term]
id: GO:0019744
name: hopanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
synonym: "hopanoid metabolism" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process

[Term]
id: GO:0019745
name: pentacyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732]
synonym: "pentacyclic triterpenoid anabolism" EXACT []
synonym: "pentacyclic triterpenoid biosynthesis" EXACT []
synonym: "pentacyclic triterpenoid formation" EXACT []
synonym: "pentacyclic triterpenoid synthesis" EXACT []
is_a: GO:0016104 ! triterpenoid biosynthetic process
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process

[Term]
id: GO:0019746
name: hopanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
synonym: "hopanoid anabolism" EXACT []
synonym: "hopanoid biosynthesis" EXACT []
synonym: "hopanoid formation" EXACT []
synonym: "hopanoid synthesis" EXACT []
is_a: GO:0016104 ! triterpenoid biosynthetic process
is_a: GO:0019744 ! hopanoid metabolic process

[Term]
id: GO:0019747
name: regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators]
synonym: "regulation of isoprenoid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0019748
name: secondary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_pombe
synonym: "secondary metabolism" EXACT []
synonym: "secondary metabolite metabolic process" EXACT []
synonym: "secondary metabolite metabolism" EXACT []
xref: Wikipedia:Secondary_metabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019749
name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte
namespace: biological_process
def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai]
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport

[Term]
id: GO:0019750
name: chloroplast localization
namespace: biological_process
def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732]
synonym: "chloroplast localisation" EXACT [GOC:mah]
is_a: GO:0051644 ! plastid localization

[Term]
id: GO:0019751
name: polyol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [PMID:30240188]
synonym: "polyhydric alcohol metabolic process" EXACT []
synonym: "polyol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0019752
name: carboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
synonym: "carboxylic acid metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0019755
name: one-carbon compound transport
namespace: biological_process
def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "one carbon compound transport" EXACT []
is_a: GO:0006810 ! transport

[Term]
id: GO:0019756
name: cyanogenic glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]
synonym: "cyanogenic glycoside anabolism" EXACT []
synonym: "cyanogenic glycoside biosynthesis" EXACT []
synonym: "cyanogenic glycoside formation" EXACT []
synonym: "cyanogenic glycoside synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0042341 ! cyanogenic glycoside metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0080028 ! nitrile biosynthetic process

[Term]
id: GO:0019757
name: obsolete glycosinolate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
comment: The reason for obsoletion is that this term was an unnecessary grouping term for glucosinolate.
synonym: "glycosinolate metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0019758
name: obsolete glycosinolate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
comment: The reason for obsoletion is that this term was an unnecessary grouping term for glucosinolate.
synonym: "glycosinolate anabolism" EXACT []
synonym: "glycosinolate biosynthesis" EXACT []
synonym: "glycosinolate formation" EXACT []
synonym: "glycosinolate synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0019759
name: obsolete glycosinolate catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
comment: The reason for obsoletion is that this term was an unnecessary grouping term for glucosinolate.
synonym: "glycosinolate breakdown" EXACT []
synonym: "glycosinolate catabolism" EXACT []
synonym: "glycosinolate degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0019760
name: glucosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [GOC:curators]
synonym: "glucosinolate metabolism" EXACT []
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0019761
name: glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai]
synonym: "glucosinolate anabolism" EXACT []
synonym: "glucosinolate biosynthesis" EXACT []
synonym: "glucosinolate formation" EXACT []
synonym: "glucosinolate synthesis" EXACT []
is_a: GO:0016144 ! S-glycoside biosynthetic process
is_a: GO:0019760 ! glucosinolate metabolic process

[Term]
id: GO:0019762
name: glucosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai]
synonym: "glucosinolate breakdown" EXACT []
synonym: "glucosinolate catabolism" EXACT []
synonym: "glucosinolate degradation" EXACT []
xref: MetaCyc:PWY-5267
is_a: GO:0016145 ! S-glycoside catabolic process
is_a: GO:0019760 ! glucosinolate metabolic process

[Term]
id: GO:0019763
name: immunoglobulin receptor activity
namespace: molecular_function
alt_id: GO:0016489
def: "Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, ISBN:0198547684]
synonym: "FC receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140375 ! immune receptor activity

[Term]
id: GO:0019764
name: obsolete high affinity Fc receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it is an unnecessary grouping term.
synonym: "high affinity Fc receptor activity" EXACT []
is_obsolete: true
consider: GO:0019768
consider: GO:0019771

[Term]
id: GO:0019765
name: obsolete low affinity Fc receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it is undefined and is an unnecessary grouping term.
synonym: "low affinity Fc receptor activity" EXACT []
is_obsolete: true
consider: GO:0019769
consider: GO:0019772

[Term]
id: GO:0019766
name: IgA receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity

[Term]
id: GO:0019767
name: IgE receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity

[Term]
id: GO:0019768
name: high-affinity IgE receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "high affinity Fc receptor activity" RELATED []
synonym: "high affinity IgE receptor activity" EXACT []
is_a: GO:0019767 ! IgE receptor activity

[Term]
id: GO:0019769
name: low-affinity IgE receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "low affinity Fc receptor activity" RELATED []
synonym: "low affinity IgE receptor activity" EXACT []
is_a: GO:0019767 ! IgE receptor activity

[Term]
id: GO:0019770
name: IgG receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity

[Term]
id: GO:0019771
name: high-affinity IgG receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "high affinity Fc receptor activity" RELATED []
synonym: "high affinity IgG receptor activity" EXACT []
is_a: GO:0019770 ! IgG receptor activity

[Term]
id: GO:0019772
name: low-affinity IgG receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "low affinity Fc receptor activity" RELATED []
synonym: "low affinity IgG receptor activity" EXACT []
is_a: GO:0019770 ! IgG receptor activity

[Term]
id: GO:0019773
name: proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0005839 ! proteasome core complex

[Term]
id: GO:0019774
name: proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0005839 ! proteasome core complex

[Term]
id: GO:0019775
name: FAT10 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages." [GOC:dph, GOC:mah, PMID:12826404]
synonym: "FAT10 conjugating enzyme activity" NARROW []
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019776
name: Atg8-family ligase activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifier to phosphatidylethanolamine or phosphatidylserine on a membrane." [PMID:12826404]
synonym: "APG8 ligase activity" EXACT []
synonym: "Atg8 ligase activity" NARROW []
synonym: "Atg8-like ligase activity" EXACT []
xref: Reactome:R-HSA-5681981 "ATG3 transfers LC3 from ATG7 to ATG3"
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0019777
name: Atg12 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404]
synonym: "APG12 conjugating enzyme activity" NARROW []
synonym: "APG12 ligase activity" NARROW []
synonym: "Atg12 conjugating enzyme activity" NARROW []
synonym: "Atg12 ligase activity" NARROW []
xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10"
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019778
name: Atg12 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "APG12 activating enzyme activity" RELATED [GOC:vw]
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0019779
name: Atg8 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "APG7" EXACT []
synonym: "APG8 activating enzyme activity" RELATED [GOC:vw]
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0019780
name: FAT10 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0019781
name: NEDD8 activating enzyme activity
namespace: molecular_function
alt_id: GO:0019944
def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924]
synonym: "RUB1 activating enzyme activity" EXACT []
xref: EC:6.2.1.64
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0019782
name: ISG15 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "UBE1L" NARROW []
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0019783
name: ubiquitin-like protein peptidase activity
namespace: molecular_function
alt_id: GO:0070138
alt_id: GO:0140491
alt_id: GO:1904454
alt_id: GO:1904455
def: "An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins." [PMID:19489724]
comment: While ubiquitin-like proteins can be rarely linked to substrates via bonds other than isopeptide bonds, all known ubiquitin-like peptidases cleave the isopeptide bond.
synonym: "small conjugating protein-specific isopeptidase activity" EXACT [GOC:dph]
synonym: "small conjugating protein-specific protease activity" EXACT [GOC:dph]
synonym: "ubiquitin-like hydrolase activity" EXACT []
synonym: "ubiquitin-like protein-specific isopeptidase activity" EXACT []
synonym: "ubiquitin-like protein-specific protease activity" EXACT []
synonym: "ubiquitin-like specific protease activity" NARROW []
synonym: "ubiquitin-like-protein-specific protease activity" NARROW []
synonym: "ubiquitin-specific protease activity involved in negative regulation of ERAD pathway" NARROW []
synonym: "ubiquitin-specific protease activity involved in positive regulation of ERAD pathway" NARROW []
synonym: "ubiquitinyl-like hydrolase activity" EXACT []
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0019784
name: deNEDDylase activity
namespace: molecular_function
def: "An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated." [GOC:mah, PMID:25628956]
synonym: "NEDD8-specific protease activity" EXACT []
xref: Reactome:R-HSA-5690808 "UCHL3, SENP8 cleave NEDD8"
xref: Reactome:R-HSA-8863723 "COP9 and TOR1 deneddylate STON2"
xref: Reactome:R-HSA-8956040 "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes"
xref: Reactome:R-HSA-8956045 "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex"
is_a: GO:0019783 ! ubiquitin-like protein peptidase activity

[Term]
id: GO:0019785
name: ISG15-specific peptidase activity
namespace: molecular_function
def: "A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated." [GOC:mah, PMID:30213559]
synonym: "ISG15-specific protease activity" EXACT []
xref: Reactome:R-HSA-1678841 "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18"
xref: Reactome:R-HSA-5653786 "USP43 deISGylates ISG:K164,ISG:K168-PCNA"
xref: Reactome:R-HSA-9729725 "SARS-CoV-2 nsp3 deISGylates ISGylated IRF3"
xref: Reactome:R-HSA-9755244 "SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1"
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0019783 ! ubiquitin-like protein peptidase activity

[Term]
id: GO:0019786
name: protein-phosphatidylethanolamide deconjugating activity
namespace: molecular_function
def: "Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328]
synonym: "APG8-PE hydrolase" RELATED []
synonym: "APG8-specific protease activity" NARROW [GOC:vw]
synonym: "ATG8-PE deconjugation activity" NARROW []
synonym: "ATG8-PE hydrolase activity" NARROW []
synonym: "Atg8-specific peptidase activity" NARROW []
synonym: "Atg8-specific protease activity" EXACT []
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0019787
name: ubiquitin-like protein transferase activity
namespace: molecular_function
alt_id: GO:0008639
alt_id: GO:0008640
def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]
subset: goslim_drosophila
subset: goslim_pir
synonym: "E2" BROAD []
synonym: "E3" RELATED [GOC:dph]
synonym: "small conjugating protein ligase activity" NARROW [GOC:dph]
synonym: "small conjugating protein transferase activity" EXACT [GOC:dph]
synonym: "small protein conjugating enzyme activity" NARROW []
synonym: "ubiquitin-like conjugating enzyme activity" NARROW []
synonym: "ubiquitin-like-protein ligase activity" NARROW []
xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE"
xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated"
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0019788
name: NEDD8 transferase activity
namespace: molecular_function
alt_id: GO:0016976
alt_id: GO:0019945
alt_id: GO:0042295
def: "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah]
synonym: "Hub1 conjugating enzyme activity" RELATED []
synonym: "NEDD8 conjugating enzyme activity" RELATED []
synonym: "RUB1 conjugating enzyme activity" RELATED []
xref: Reactome:R-HSA-8951648 "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1"
xref: Reactome:R-HSA-8951661 "Transfer of NEDD8 to AcM-UBE2M"
xref: Reactome:R-HSA-8951764 "Transfer of NEDD8 to AcM-UBE2F"
xref: Reactome:R-HSA-8952044 "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex"
xref: Reactome:R-HSA-8952618 "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex"
xref: Reactome:R-HSA-8952626 "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex"
xref: Reactome:R-HSA-8952631 "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex"
xref: Reactome:R-HSA-8952638 "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex"
xref: Reactome:R-HSA-8956025 "AcM-UBE2M transfers NEDD8 to CUL9:RBX1"
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019789
name: SUMO transferase activity
namespace: molecular_function
alt_id: GO:0016930
alt_id: GO:0019949
def: "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250]
synonym: "SMT3 conjugating enzyme" RELATED []
synonym: "SUMO conjugating enzyme activity" RELATED []
xref: Reactome:R-HSA-2993769 "Transfer of SUMO3 from E1 to UBE2I (UBC9)"
xref: Reactome:R-HSA-2993780 "Transfer of SUMO1 from E1 to UBE2I (UBC9)"
xref: Reactome:R-HSA-2993790 "Transfer of SUMO2 from E1 to UBE2I (UBC9)"
xref: Reactome:R-HSA-2997616 "PIAS1,4 SUMOylates BRCA1 with SUMO2,3"
xref: Reactome:R-HSA-2997706 "MDM2 SUMOylates TP53 with SUMO2,3"
xref: Reactome:R-HSA-2997709 "PIAS1,4 SUMOylates BRCA1 with SUMO1"
xref: Reactome:R-HSA-2997723 "PIAS4 SUMOylates TP53BP1 with SUMO1"
xref: Reactome:R-HSA-3000348 "RANBP2 SUMOylates SP100 with SUMO2"
xref: Reactome:R-HSA-3000383 "UBE2I, HDAC7 SUMOylate PML with SUMO1"
xref: Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1"
xref: Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2"
xref: Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3"
xref: Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1"
xref: Reactome:R-HSA-3000449 "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2"
xref: Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3"
xref: Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1"
xref: Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1"
xref: Reactome:R-HSA-3232162 "PIAS3 SUMOylates MITF with SUMO1"
xref: Reactome:R-HSA-3234081 "SUMOylation of TFAP2A with SUMO1"
xref: Reactome:R-HSA-3234084 "SUMOylation of TFAP2B with SUMO1"
xref: Reactome:R-HSA-3234094 "SUMOylation of TFAP2C with SUMO1"
xref: Reactome:R-HSA-3247493 "PIAS1 SUMOylates SP3 with SUMO1"
xref: Reactome:R-HSA-3296126 "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1"
xref: Reactome:R-HSA-3465545 "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3"
xref: Reactome:R-HSA-3782535 "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1"
xref: Reactome:R-HSA-3899291 "SUMOylation of EP300 with SUMO1"
xref: Reactome:R-HSA-3900047 "SUMOylation of DDX17 with SUMO1"
xref: Reactome:R-HSA-3900070 "SUMOylation of MKL1 with SUMO1"
xref: Reactome:R-HSA-3900177 "SUMOylation of DDX5 with SUMO1"
xref: Reactome:R-HSA-3900194 "PIAS1 SUMOylates DDX5 with SUMO2"
xref: Reactome:R-HSA-3903017 "SUMOylation of PPARGC1A with SUMO1"
xref: Reactome:R-HSA-3927824 "PRC1 SUMOylates CASP8AP2 with SUMO1"
xref: Reactome:R-HSA-3927886 "SUMOylation of NCOR2 with SUMO1"
xref: Reactome:R-HSA-3927959 "SUMOylation of CREBBP with SUMO1"
xref: Reactome:R-HSA-3968362 "SUMOylation of PIAS4 with SUMO1"
xref: Reactome:R-HSA-3968414 "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1"
xref: Reactome:R-HSA-4085296 "SUMOylation of NCOA1 with SUMO1"
xref: Reactome:R-HSA-4085318 "SUMOylation of NCOA2 with SUMO1"
xref: Reactome:R-HSA-4085331 "PIAS2-1 SUMOylates PARK7 with SUMO1"
xref: Reactome:R-HSA-4085347 "PIAS1 SUMOylates SAFB with SUMO1"
xref: Reactome:R-HSA-4085350 "SUMOylation of UBE2I with SUMO1"
xref: Reactome:R-HSA-4085372 "PIAS1 SUMOylates SAFB with SUMO2,3"
xref: Reactome:R-HSA-4085992 "SUMOylation of DAXX with SUMO1"
xref: Reactome:R-HSA-4085994 "TOPORS SUMOylates SIN3A with SUMO1"
xref: Reactome:R-HSA-4086036 "PIAS1,3 SUMOylate NRIP1 with SUMO1"
xref: Reactome:R-HSA-4086059 "SUMOylation of NPM1 with SUMO2,3"
xref: Reactome:R-HSA-4086083 "SUMOylation of ING2 with SUMO1"
xref: Reactome:R-HSA-4086088 "SUMOylation of NPM1 with SUMO1"
xref: Reactome:R-HSA-4090281 "PIAS1,2-1 SUMOylate HIC1 with SUMO1"
xref: Reactome:R-HSA-4090284 "SUMOylation of HIPK2 with SUMO1"
xref: Reactome:R-HSA-4090288 "PIAS1,3 SUMOylate MBD1 with SUMO1"
xref: Reactome:R-HSA-4090390 "PIAS1,2-1 SUMOylates AR with SUMO1"
xref: Reactome:R-HSA-4090408 "PIAS1,3 SUMOylate ESR1 with SUMO1"
xref: Reactome:R-HSA-4341016 "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1"
xref: Reactome:R-HSA-4341025 "SUMOylation of NR3C1 (GR) with SUMO1"
xref: Reactome:R-HSA-4341048 "SUMOylation of RXRA with SUMO1"
xref: Reactome:R-HSA-4341070 "PIAS4 SUMOylates PPARA with SUMO1"
xref: Reactome:R-HSA-4341072 "SUMOylation of RARA with SUMO2"
xref: Reactome:R-HSA-4341073 "PIAS3 SUMOylates PGR with SUMO1"
xref: Reactome:R-HSA-4546385 "PIAS1,3 SUMOylates NR5A1 with SUMO2"
xref: Reactome:R-HSA-4546386 "PIAS1,3 SUMOylates NR5A1 with SUMO1"
xref: Reactome:R-HSA-4546387 "PIAS4 SUMOylates VDR with SUMO2"
xref: Reactome:R-HSA-4551604 "PIAS4 SUMOylates PARP1 with SUMO1"
xref: Reactome:R-HSA-4551616 "SUMOylation of RPA1 (RPA70) with SUMO2,3"
xref: Reactome:R-HSA-4551648 "SUMOylation of TDG with SUMO1"
xref: Reactome:R-HSA-4551649 "RANBP2 SUMOylates RANBP2 with SUMO1"
xref: Reactome:R-HSA-4551655 "CBX4 SUMOylates BMI1 in PRC1 with SUMO1"
xref: Reactome:R-HSA-4551661 "PIAS4 SUMOylates RNF168 with SUMO1"
xref: Reactome:R-HSA-4551679 "RANBP2 SUMOylates RANBP2 with SUMO2"
xref: Reactome:R-HSA-4551683 "SUMOylation of TOPORS with SUMO1"
xref: Reactome:R-HSA-4551721 "PIAS4 SUMOylates VHL with SUMO1"
xref: Reactome:R-HSA-4551724 "PIAS4 SUMOylates HERC2 with SUMO1"
xref: Reactome:R-HSA-4551727 "CBX4 SUMOylates CBX4 in PRC1 with SUMO1"
xref: Reactome:R-HSA-4551738 "SUMOylation of TDG with SUMO2,3"
xref: Reactome:R-HSA-4551768 "PIAS4 SUMOylates PARP1 with SUMO2,3"
xref: Reactome:R-HSA-4568846 "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1"
xref: Reactome:R-HSA-4568848 "PIAS1,2-1 SUMOylates XRCC4 with SUMO1"
xref: Reactome:R-HSA-4568863 "SUMOylation of RAD52 with SUMO1"
xref: Reactome:R-HSA-4568914 "SUMOylation of BLM with SUMO2,3"
xref: Reactome:R-HSA-4570463 "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3"
xref: Reactome:R-HSA-4570467 "SUMOylation of NOP58 with SUMO1"
xref: Reactome:R-HSA-4570485 "SUMOylation of Histone H4 with SUMO3"
xref: Reactome:R-HSA-4570489 "SUMOylation of NOP58 with SUMO2"
xref: Reactome:R-HSA-4570493 "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1"
xref: Reactome:R-HSA-4570496 "SUMOylation of Histone H4 with SUMO1"
xref: Reactome:R-HSA-4570499 "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2"
xref: Reactome:R-HSA-4570528 "SUMOylation of XPC with SUMO1"
xref: Reactome:R-HSA-4570553 "SUMOylation of MDC1 with SUMO2,3"
xref: Reactome:R-HSA-4570554 "SUMOylation of MDC1 with SUMO1"
xref: Reactome:R-HSA-4615839 "PIAS1 SUMOylates SATB1 with SUMO2,3"
xref: Reactome:R-HSA-4615872 "RANBP2 SUMOylates HDAC4 with SUMO1"
xref: Reactome:R-HSA-4615873 "PIAS2-2 SUMOylates SUZ12 with SUMO1"
xref: Reactome:R-HSA-4615889 "SUMOylation of HDAC1 with SUMO1"
xref: Reactome:R-HSA-4615900 "PIAS1 SUMOylates SATB2 with SUMO3"
xref: Reactome:R-HSA-4615905 "PIAS1 SUMOylates SATB1 with SUMO1"
xref: Reactome:R-HSA-4615910 "SUMOylation of PCNA with SUMO1"
xref: Reactome:R-HSA-4615933 "SUMOylation of CBX5 with SUMO1"
xref: Reactome:R-HSA-4615987 "RANBP2 SUMOylates HDAC4 with SUMO2,3"
xref: Reactome:R-HSA-4616015 "SUMOylation of HDAC2 with SUMO1"
xref: Reactome:R-HSA-4641342 "SUMOylation of TOP2A with SUMO1"
xref: Reactome:R-HSA-4641345 "SUMOylation of TOP2B with SUMO1"
xref: Reactome:R-HSA-4641350 "PIAS4 SUMOylates TOP2A with SUMO2,3"
xref: Reactome:R-HSA-4641362 "SUMOylation of TOP1 with SUMO1"
xref: Reactome:R-HSA-4655355 "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)"
xref: Reactome:R-HSA-4655374 "SUMOylation of DNMT3B with SUMO1"
xref: Reactome:R-HSA-4655431 "SUMOyation of DNMT1 with SUMO1"
xref: Reactome:R-HSA-4655440 "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1"
xref: Reactome:R-HSA-4656914 "SUMOylation of NFKBIA with SUMO1"
xref: Reactome:R-HSA-4717461 "PIAS1,2-2 SUMOylate PPARG with SUMO1"
xref: Reactome:R-HSA-4717521 "PIAS1 SUMOylates NR2C1 (TR2)"
xref: Reactome:R-HSA-4719413 "PIAS2,3,4 SUMOylate RORA with SUMO2"
xref: Reactome:R-HSA-4719423 "PIAS2-2 SUMOylates THRA with SUMO3"
xref: Reactome:R-HSA-4719424 "PIAS1 SUMOylates THRB with SUMO1"
xref: Reactome:R-HSA-4719436 "PIAS2,3,4 SUMOylate RORA with SUMO1"
xref: Reactome:R-HSA-4719447 "PIAS2-2 SUMOylates THRA with SUMO1"
xref: Reactome:R-HSA-4719448 "PIAS1 SUMOylates THRB with SUMO3"
xref: Reactome:R-HSA-4720432 "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3"
xref: Reactome:R-HSA-4720446 "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3"
xref: Reactome:R-HSA-4755411 "PIAS4 SUMOylates IKBKG with SUMO1"
xref: Reactome:R-HSA-4755478 "TOPORS SUMOylates IKBKE with SUMO1"
xref: Reactome:R-HSA-4755479 "SUMOylation of NFKB2 with SUMO1"
xref: Reactome:R-HSA-4755494 "PIAS1,2-1 SUMOylate NR5A2 with SUMO1"
xref: Reactome:R-HSA-4755526 "PIAS4 SUMOylates NR4A2 with SUMO2,3"
xref: Reactome:R-HSA-4755536 "PIAS3 SUMOylates RELA with SUMO3"
xref: Reactome:R-HSA-5228508 "RANBP2 SUMOylates PML with SUMO1"
xref: Reactome:R-HSA-5228521 "PIAS1,4 SUMOylate CASP8AP2 with SUMO1"
xref: Reactome:R-HSA-5228523 "RANBP2 SUMOylates MDM2 with SUMO1"
xref: Reactome:R-HSA-5228525 "RANBP2 SUMOylates TOP2A with SUMO1"
xref: Reactome:R-HSA-5682607 "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs"
xref: Reactome:R-HSA-5684052 "PIAS4 SUMOylates MDC1"
xref: Reactome:R-HSA-6790454 "SUMOylation of XPC"
xref: Reactome:R-HSA-6804468 "PIAS1 SUMOylates SP3 with SUMO2"
xref: Reactome:R-HSA-6804485 "PIAS1 SUMOylates L3MBTL2 with SUMO2"
xref: Reactome:R-HSA-8956365 "ZBED1 (DREF) SUMOylates CHD3 with SUMO1"
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019790
name: obsolete ubiquitin-like hydrolase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "ubiquitin-like hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019791
name: obsolete FAT10 hydrolase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "FAT10 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019792
name: obsolete APG12 hydrolase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "APG12 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019793
name: obsolete ISG15 carrier activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/]
comment: This term was made obsolete because it is gene product-specific.
synonym: "interferon-stimulated gene-15 carrier activity" NARROW []
synonym: "ISG15 carrier activity" EXACT []
is_obsolete: true

[Term]
id: GO:0019794
name: obsolete nonprotein amino acid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
synonym: "nonprotein amino acid metabolic process" EXACT []
synonym: "nonprotein amino acid metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006520

[Term]
id: GO:0019795
name: obsolete nonprotein amino acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
synonym: "nonprotein amino acid anabolism" EXACT []
synonym: "nonprotein amino acid biosynthesis" EXACT []
synonym: "nonprotein amino acid biosynthetic process" EXACT []
synonym: "nonprotein amino acid formation" EXACT []
synonym: "nonprotein amino acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0008652

[Term]
id: GO:0019796
name: obsolete nonprotein amino acid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
synonym: "nonprotein amino acid breakdown" EXACT []
synonym: "nonprotein amino acid catabolic process" EXACT []
synonym: "nonprotein amino acid catabolism" EXACT []
synonym: "nonprotein amino acid degradation" EXACT []
is_obsolete: true
replaced_by: GO:0009063

[Term]
id: GO:0019797
name: procollagen-proline 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7, RHEA:22872]
synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.7]
synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" RELATED [EC:1.14.11.7]
synonym: "proline,2-oxoglutarate 3-dioxygenase activity" RELATED [EC:1.14.11.7]
synonym: "prolyl 3-hydroxylase activity" BROAD [EC:1.14.11.7]
synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" RELATED [EC:1.14.11.7]
synonym: "protocollagen proline 3-hydroxylase activity" RELATED [EC:1.14.11.7]
xref: EC:1.14.11.7
xref: KEGG_REACTION:R03218
xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN
xref: Reactome:R-HSA-1980233 "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen"
xref: RHEA:22872
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity

[Term]
id: GO:0019798
name: procollagen-proline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2." [GOC:mah, PMID:4371784]
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0019799
name: tubulin N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" RELATED [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" RELATED [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" RELATED [EC:2.3.1.108]
synonym: "alpha-tubulin acetylase activity" RELATED [EC:2.3.1.108]
synonym: "alpha-tubulin acetyltransferase activity" RELATED [EC:2.3.1.108]
synonym: "alpha-tubulin N-acetyltransferase activity" RELATED [EC:2.3.1.108]
synonym: "TAT activity" RELATED [EC:2.3.1.108]
synonym: "tubulin acetyltransferase activity" RELATED [EC:2.3.1.108]
xref: EC:2.3.1.108
xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN
xref: RHEA:15277
is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity

[Term]
id: GO:0019800
name: obsolete peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
namespace: biological_process
def: "OBSOLETE. The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT []
xref: RESID:AA0219
is_obsolete: true

[Term]
id: GO:0019801
name: cyclization of asparagine involved in intein-mediated protein splicing
namespace: biological_process
def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302]
comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'.
synonym: "cyclization of asparagine, during protein splicing" RELATED [GOC:dph, GOC:tb]
xref: RESID:AA0302
is_a: GO:0006528 ! asparagine metabolic process
relationship: part_of GO:0016539 ! intein-mediated protein splicing

[Term]
id: GO:0019802
name: cyclization of glutamine involved in intein-mediated protein splicing
namespace: biological_process
def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [GOC:dph, GOC:tb, RESID:AA0303]
comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'.
synonym: "cyclization of glutamine, during protein splicing" RELATED [GOC:dph, GOC:tb]
xref: RESID:AA0303
is_a: GO:0006541 ! glutamine metabolic process
relationship: part_of GO:0016539 ! intein-mediated protein splicing

[Term]
id: GO:0019803
name: obsolete peptidyl-aspartic acid carboxylation
namespace: biological_process
def: "OBSOLETE. The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019804
name: obsolete quinolinate synthetase complex
namespace: cellular_component
def: "OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902]
comment: This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers.
synonym: "quinolinate synthetase complex" EXACT []
is_obsolete: true
consider: GO:0008743
consider: GO:0008987

[Term]
id: GO:0019805
name: quinolinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]
synonym: "quinolinate anabolism" EXACT []
synonym: "quinolinate biosynthesis" EXACT []
synonym: "quinolinate formation" EXACT []
synonym: "quinolinate synthesis" EXACT []
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046874 ! quinolinate metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0019806
name: bromide peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.18]
synonym: "bromoperoxidase activity" EXACT []
xref: EC:1.11.1.18
is_a: GO:0140905 ! haloperoxidase activity

[Term]
id: GO:0019807
name: aspartoacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15]
synonym: "acetyl-aspartic deaminase activity" RELATED [EC:3.5.1.15]
synonym: "acylase II" RELATED [EC:3.5.1.15]
synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15]
synonym: "N-acetylaspartate amidohydrolase activity" RELATED [EC:3.5.1.15]
synonym: "N-acyl-L-aspartate amidohydrolase activity" RELATED [EC:3.5.1.15]
xref: EC:3.5.1.15
xref: MetaCyc:ASPARTOACYLASE-RXN
xref: Reactome:R-HSA-5691507 "ASPA deacetylates NAA to acetate and L-aspartate"
xref: RHEA:10872
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019808
name: polyamine binding
namespace: molecular_function
def: "Binding to a polyamine, an organic compound containing two or more amino groups." [GOC:ai]
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0019809
name: spermidine binding
namespace: molecular_function
def: "Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
is_a: GO:0019808 ! polyamine binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0019810
name: putrescine binding
namespace: molecular_function
def: "Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai]
is_a: GO:0019808 ! polyamine binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0019811
name: cocaine binding
namespace: molecular_function
def: "Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732]
is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0019812
name: type I site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748]
synonym: "type I restriction enzyme complex" EXACT []
is_a: GO:1905347 ! endodeoxyribonuclease complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0019813
name: type III site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
synonym: "type III restriction enzyme complex" EXACT []
is_a: GO:1905347 ! endodeoxyribonuclease complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0019814
name: immunoglobulin complex
namespace: cellular_component
def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
subset: goslim_pir
synonym: "antibody" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0019815
name: B cell receptor complex
namespace: cellular_component
alt_id: GO:0042570
def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "antibody" RELATED [GOC:mah]
synonym: "B cell receptor accessory molecule complex" RELATED []
synonym: "B lymphocyte receptor complex" EXACT []
synonym: "B-cell receptor complex" EXACT []
synonym: "B-lymphocyte receptor complex" EXACT []
synonym: "BCR complex" EXACT []
synonym: "immunoglobulin complex, membrane bound" EXACT []
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0019816
name: obsolete B cell receptor accessory molecule complex
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecule and not a location or complex.
synonym: "B cell receptor accessory molecule complex" EXACT []
is_obsolete: true
consider: GO:0019815

[Term]
id: GO:0019817
name: vesicle fusion with peroxisome
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jid]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0007031 ! peroxisome organization

[Term]
id: GO:0019819
name: P1 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019820
name: P2 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019821
name: P3 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019822
name: P4 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019823
name: P5 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019824
name: P6 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019825
name: oxygen binding
namespace: molecular_function
def: "Binding to oxygen (O2)." [GOC:jl]
subset: goslim_pir
subset: goslim_plant
synonym: "cytochrome P450" NARROW []
synonym: "cytochrome P450 activity" RELATED []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0019826
name: oxygen sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah]
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0019827
name: stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
synonym: "maintenance of pluripotency" RELATED [GOC:vk]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0098727 ! maintenance of cell number

[Term]
id: GO:0019828
name: aspartic-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases." [GOC:ai]
synonym: "aspartic protease inhibitor activity" NARROW []
is_a: GO:0004866 ! endopeptidase inhibitor activity

[Term]
id: GO:0019829
name: ATPase-coupled monoatomic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
synonym: "ATP-dependent cation transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled cation transmembrane transporter activity" BROAD []
synonym: "cation ABC transporter" NARROW []
synonym: "cation-transporting ATPase activity" EXACT []
synonym: "plasma membrane cation-transporting ATPase" NARROW []
xref: Reactome:R-HSA-5251989 "ATP13A4,5 transport divalent ions from extracellular region to cytosol"
xref: Reactome:R-HSA-5692480 "ATP13A2 transports cations from cytosol to lysosomal lumen"
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0019830
name: obsolete cadmium sensitivity/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "cadmium sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046686

[Term]
id: GO:0019831
name: obsolete chromate sensitivity/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "chromate sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046687

[Term]
id: GO:0019832
name: obsolete mercuric sensitivity/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "mercuric sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046689

[Term]
id: GO:0019833
name: ice nucleation activity
namespace: molecular_function
def: "Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees Celsius) to protect the organism from damage by intracellular ice formation. This process is commonly found in certain bacteria, such as Pseudomonas syringae, and plays roles in environmental adaptation and plant pathogenesis." [GOC:cjm, PMID:35551271, UniProt:KW-0387]
comment: Note that this term was reinstated from obsolete.
xref: TC:9.B.133.1.1
is_a: GO:0050825 ! ice binding

[Term]
id: GO:0019834
name: phospholipase A2 inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of phospholipase A2." [GOC:ai]
is_a: GO:0004859 ! phospholipase inhibitor activity

[Term]
id: GO:0019835
name: cytolysis
namespace: biological_process
def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204]
subset: goslim_chembl
synonym: "autolysin activity" RELATED []
synonym: "bacteriocin activity" RELATED []
synonym: "bacteriolytic toxin activity" RELATED []
synonym: "holin" RELATED []
synonym: "lysin activity" RELATED []
synonym: "lysis" BROAD []
synonym: "necrosis" RELATED []
xref: Wikipedia:Cytolysis
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0019836
name: hemolysis by symbiont of host erythrocytes
namespace: biological_process
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354]
synonym: "haemolysis in host" EXACT []
synonym: "hemolysin activity" RELATED []
synonym: "hemolysis by symbiont of host RBCs" EXACT [CL:0000232]
synonym: "hemolysis by symbiont of host red blood cells" EXACT [CL:0000232]
synonym: "pathogenesis" RELATED []
synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001897 ! symbiont-mediated cytolysis of host cell

[Term]
id: GO:0019837
name: obsolete herbicide susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "herbicide susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009635

[Term]
id: GO:0019838
name: growth factor binding
namespace: molecular_function
def: "Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]
subset: goslim_chembl
synonym: "neurotrophin TRK receptor activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019840
name: isoprenoid binding
namespace: molecular_function
def: "Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl]
subset: goslim_pir
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0019841
name: retinol binding
namespace: molecular_function
def: "Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [GOC:curators]
synonym: "vitamin A1 alcohol binding" EXACT []
synonym: "vitamin A1 binding" EXACT []
is_a: GO:0005501 ! retinoid binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0019842
name: vitamin binding
namespace: molecular_function
def: "Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_metagenomics
subset: goslim_pir
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0019843
name: rRNA binding
namespace: molecular_function
alt_id: GO:0000944
def: "Binding to a ribosomal RNA." [GOC:jl]
subset: goslim_chembl
subset: goslim_yeast
synonym: "base pairing with rRNA" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0019844
name: obsolete endotoxin activity
namespace: molecular_function
def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "endotoxin activity" EXACT []
is_obsolete: true
consider: GO:0005622
consider: GO:0090729

[Term]
id: GO:0019845
name: obsolete exotoxin activity
namespace: molecular_function
def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "exotoxin activity" EXACT []
is_obsolete: true
consider: GO:0005576
consider: GO:0090729

[Term]
id: GO:0019846
name: obsolete enterotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "enterotoxin activity" EXACT []
is_obsolete: true
consider: GO:0090729

[Term]
id: GO:0019847
name: obsolete neurotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "neurotoxin activity" EXACT []
is_obsolete: true
consider: GO:0090729

[Term]
id: GO:0019848
name: obsolete conotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "conotoxin activity" EXACT []
is_obsolete: true
consider: GO:0019855
consider: GO:0046929

[Term]
id: GO:0019849
name: obsolete cytotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "cytotoxin activity" EXACT []
is_obsolete: true
consider: GO:0090729

[Term]
id: GO:0019852
name: L-ascorbic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:jl, ISBN:0198506732]
synonym: "ascorbate metabolic process" EXACT []
synonym: "ascorbate metabolism" EXACT []
synonym: "L-ascorbic acid metabolism" EXACT []
synonym: "vitamin C metabolic process" EXACT []
synonym: "vitamin C metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:0019853
name: L-ascorbic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:ma, ISBN:0198547684]
synonym: "ascorbate biosynthesis" EXACT []
synonym: "ascorbate biosynthetic process" EXACT []
synonym: "L-ascorbic acid anabolism" EXACT []
synonym: "L-ascorbic acid biosynthesis" EXACT []
synonym: "L-ascorbic acid formation" EXACT []
synonym: "L-ascorbic acid synthesis" EXACT []
synonym: "vitamin C biosynthesis" EXACT []
synonym: "vitamin C biosynthetic process" EXACT []
xref: MetaCyc:PWY-882
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0019854
name: L-ascorbic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:go_curators]
synonym: "ascorbate catabolic process" EXACT []
synonym: "ascorbate catabolism" EXACT []
synonym: "L-ascorbic acid breakdown" EXACT []
synonym: "L-ascorbic acid catabolism" EXACT []
synonym: "L-ascorbic acid degradation" EXACT []
synonym: "vitamin C catabolic process" EXACT []
synonym: "vitamin C catabolism" EXACT []
xref: MetaCyc:PWY0-301
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901335 ! lactone catabolic process

[Term]
id: GO:0019855
name: calcium channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of a calcium channel." [GOC:mah]
is_a: GO:0005246 ! calcium channel regulator activity
is_a: GO:0008200 ! ion channel inhibitor activity

[Term]
id: GO:0019856
name: pyrimidine nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]
synonym: "pyrimidine base anabolism" EXACT []
synonym: "pyrimidine base biosynthesis" EXACT []
synonym: "pyrimidine base biosynthetic process" EXACT [GOC:go_curators]
synonym: "pyrimidine base formation" EXACT []
synonym: "pyrimidine base synthesis" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process
is_a: GO:0046112 ! nucleobase biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0019857
name: obsolete 5-methylcytosine metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai]
comment: This term was obsoleted because it was redundant with DNA methylation-dependent heterochromatin formation ; GO:0006346, chromosomal 5-methylcytosine DNA demethylation pathway ; GO:0141166, or their children.
synonym: "5-methylcytosine metabolism" EXACT []
is_obsolete: true
consider: GO:0006346
consider: GO:0141166

[Term]
id: GO:0019858
name: cytosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai]
synonym: "cytosine metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0019859
name: thymine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
synonym: "thymine metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0019860
name: uracil metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
synonym: "uracil metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0019861
name: obsolete flagellum
namespace: cellular_component
alt_id: GO:0008223
def: "OBSOLETE. Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [UniProtKB-KW:KW-0282]
comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum ; GO:0009288'.
synonym: "flagellum" EXACT []
xref: Wikipedia:Flagellum
is_obsolete: true
consider: GO:0005929
consider: GO:0009288

[Term]
id: GO:0019862
name: IgA binding
namespace: molecular_function
def: "Binding to an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019863
name: IgE binding
namespace: molecular_function
def: "Binding to an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019864
name: IgG binding
namespace: molecular_function
def: "Binding to an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149]
subset: goslim_chembl
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019865
name: immunoglobulin binding
namespace: molecular_function
def: "Binding to an immunoglobulin." [GOC:ma]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0019866
name: organelle inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah]
comment: See also the cellular component term 'outer membrane ; GO:0019867'.
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0019867
name: outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]
subset: goslim_metagenomics
is_a: GO:0016020 ! membrane

[Term]
id: GO:0019869
name: chloride channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of a chloride channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0017081 ! chloride channel regulator activity

[Term]
id: GO:0019870
name: potassium channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of a potassium channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0015459 ! potassium channel regulator activity

[Term]
id: GO:0019871
name: sodium channel inhibitor activity
namespace: molecular_function
alt_id: GO:0019868
def: "Binds to and stops, prevents, or reduces the activity of a sodium channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0017080 ! sodium channel regulator activity

[Term]
id: GO:0019872
name: streptomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators]
synonym: "streptomycin anabolism" EXACT []
synonym: "streptomycin biosynthesis" EXACT []
synonym: "streptomycin formation" EXACT []
synonym: "streptomycin synthesis" EXACT []
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0046343 ! streptomycin metabolic process

[Term]
id: GO:0019873
name: obsolete tellurium sensitivity/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "tellurium sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046690

[Term]
id: GO:0019874
name: 6-aminohexanoate-cyclic-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12, RHEA:16225]
synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" RELATED [EC:3.5.2.12]
xref: EC:3.5.2.12
xref: KEGG_REACTION:R03448
xref: MetaCyc:3.5.2.12-RXN
xref: RHEA:16225
xref: UM-BBD_reactionID:r1097
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0019875
name: 6-aminohexanoate-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46]
synonym: "6-aminohexanoic acid oligomer hydrolase activity" RELATED [EC:3.5.1.46]
synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" RELATED [EC:3.5.1.46]
xref: EC:3.5.1.46
xref: MetaCyc:RXN-3962
xref: RHEA:21364
xref: UM-BBD_enzymeID:r1096
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019876
name: nylon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549]
synonym: "nylon breakdown" EXACT []
synonym: "nylon catabolism" EXACT []
synonym: "nylon degradation" EXACT []
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042198 ! nylon metabolic process

[Term]
id: GO:0019877
name: diaminopimelate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684]
synonym: "diaminopimelate anabolism" EXACT []
synonym: "diaminopimelate biosynthesis" EXACT []
synonym: "diaminopimelate formation" EXACT []
synonym: "diaminopimelate synthesis" EXACT []
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046451 ! diaminopimelate metabolic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process

[Term]
id: GO:0019878
name: lysine biosynthetic process via aminoadipic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators]
synonym: "lysine anabolism via aminoadipic acid" EXACT []
synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT []
synonym: "lysine biosynthesis, aminoadipic pathway" EXACT []
synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT []
synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT []
synonym: "lysine formation via aminoadipic acid" EXACT []
synonym: "lysine synthesis via aminoadipic acid" EXACT []
is_a: GO:0009085 ! lysine biosynthetic process

[Term]
id: GO:0019879
name: obsolete peptidyl-thyronine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT []
is_obsolete: true

[Term]
id: GO:0019880
name: obsolete bacteriocin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "bacteriocin susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046678

[Term]
id: GO:0019881
name: obsolete streptomycin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "streptomycin susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046679

[Term]
id: GO:0019882
name: antigen processing and presentation
namespace: biological_process
alt_id: GO:0030333
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
synonym: "antigen presentation" EXACT []
synonym: "antigen processing" EXACT []
xref: Wikipedia:Antigen_presentation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0019883
name: antigen processing and presentation of endogenous antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
synonym: "antigen presentation, endogenous antigen" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0019884
name: antigen processing and presentation of exogenous antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
synonym: "antigen presentation, exogenous antigen" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0019885
name: antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
alt_id: GO:0048004
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, endogenous peptide antigen" BROAD []
synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD []
synonym: "antigen processing, endogenous antigen via MHC class I" BROAD []
synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen

[Term]
id: GO:0019886
name: antigen processing and presentation of exogenous peptide antigen via MHC class II
namespace: biological_process
alt_id: GO:0042591
alt_id: GO:0048005
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD []
synonym: "antigen presentation, exogenous peptide antigen" BROAD []
synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0019887
name: protein kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0019888
name: protein phosphatase regulator activity
namespace: molecular_function
alt_id: GO:0008599
alt_id: GO:0008601
alt_id: GO:0030359
alt_id: GO:0030362
def: "Binds to and modulates the activity of a protein phosphatase." [GOC:ai]
synonym: "calcineurin regulator activity" NARROW [GOC:dph, GOC:rl]
synonym: "calcineurin, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl]
synonym: "protein phosphatase 2 regulator activity" NARROW [GOC:dph, GOC:rl]
synonym: "protein phosphatase 2, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl]
synonym: "protein phosphatase 3 regulator activity" NARROW [GOC:dph, GOC:rl]
synonym: "protein phosphatase 3, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl]
synonym: "protein phosphatase type 1 regulator activity" NARROW []
synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW []
synonym: "protein phosphatase type 2A regulator activity" NARROW []
synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW []
synonym: "protein phosphatase type 2B regulator activity" NARROW []
synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW []
synonym: "protein phosphatase type 4 regulator activity" NARROW []
synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW []
xref: Reactome:R-HSA-180038 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function"
is_a: GO:0019208 ! phosphatase regulator activity

[Term]
id: GO:0019889
name: pteridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732]
synonym: "pteridine metabolism" EXACT []
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0019893
name: obsolete DNA replication inhibitor
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA replication inhibitor" EXACT []
is_obsolete: true
replaced_by: GO:0008156

[Term]
id: GO:0019894
name: kinesin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0019895
name: obsolete kinesin-associated mitochondrial adaptor activity
namespace: molecular_function
def: "OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [PMID:12495622]
comment: This term was obsoleted because it represents the function of a specific protein.
is_obsolete: true

[Term]
id: GO:0019896
name: axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai]
subset: goslim_synapse
synonym: "axon transport of mitochondria" EXACT []
is_a: GO:0047497 ! mitochondrion transport along microtubule
is_a: GO:0098930 ! axonal transport

[Term]
id: GO:0019897
name: extrinsic component of plasma membrane
namespace: cellular_component
alt_id: GO:0000157
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
synonym: "extrinsic to plasma membrane" EXACT []
synonym: "juxtamembrane" BROAD []
synonym: "peripheral plasma membrane protein" EXACT []
is_a: GO:0019898 ! extrinsic component of membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0019898
name: extrinsic component of membrane
namespace: cellular_component
alt_id: GO:0030396
def: "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
subset: goslim_metagenomics
synonym: "extrinsic to membrane" EXACT []
synonym: "peripheral membrane protein" EXACT []
xref: Wikipedia:Peripheral_membrane_protein
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0019899
name: enzyme binding
namespace: molecular_function
def: "Binding to an enzyme, a protein with catalytic activity." [GOC:jl]
subset: goslim_chembl
subset: goslim_yeast
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019900
name: kinase binding
namespace: molecular_function
def: "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0019901
name: protein kinase binding
namespace: molecular_function
def: "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
is_a: GO:0019900 ! kinase binding

[Term]
id: GO:0019902
name: phosphatase binding
namespace: molecular_function
def: "Binding to a phosphatase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0019903
name: protein phosphatase binding
namespace: molecular_function
def: "Binding to a protein phosphatase." [GOC:jl]
is_a: GO:0019902 ! phosphatase binding

[Term]
id: GO:0019904
name: protein domain specific binding
namespace: molecular_function
def: "Binding to a specific domain of a protein." [GOC:go_curators]
subset: goslim_chembl
synonym: "protein domain-specific binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019905
name: syntaxin binding
namespace: molecular_function
alt_id: GO:0030347
alt_id: GO:0030349
alt_id: GO:0050430
alt_id: GO:0051535
def: "Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]
synonym: "syntaxin-13 binding" NARROW []
synonym: "syntaxin-2 binding" NARROW []
synonym: "syntaxin-5 binding" NARROW []
synonym: "syntaxin-6 binding" NARROW []
is_a: GO:0000149 ! SNARE binding

[Term]
id: GO:0019907
name: cyclin-dependent protein kinase activating kinase holoenzyme complex
namespace: cellular_component
def: "A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH." [GOC:bhm, PMID:8752210]
synonym: "CAK complex" EXACT []
synonym: "CDK-activating kinase complex" EXACT []
is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex
is_a: GO:0150005 ! enzyme activator complex

[Term]
id: GO:0019908
name: nuclear cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc]
synonym: "CDK holoenzyme" BROAD []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0019909
name: obsolete [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase." [GOC:ai]
comment: This term was obsoleted becaus it represents the same activity as [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity ; GO:0004741.
synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW []
is_obsolete: true
replaced_by: GO:0004741

[Term]
id: GO:0019910
name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus." [GOC:mtg_sensu, PMID:9395502]
comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'.
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0019911
name: structural constituent of myelin sheath
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0019912
name: cyclin-dependent protein kinase activating kinase activity
namespace: molecular_function
alt_id: GO:0019913
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators]
synonym: "CAK" EXACT []
synonym: "cdk-activating kinase activity" EXACT []
synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT []
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0030295 ! protein kinase activator activity

[Term]
id: GO:0019914
name: cyclin-dependent protein kinase activating kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai]
synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW []
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0019915
name: lipid storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
synonym: "lipid retention" EXACT [GOC:dph, GOC:tb]
synonym: "lipid sequestering" NARROW [GOC:dph, GOC:tb]
synonym: "lipid sequestration" NARROW [GOC:dph, GOC:tb]
synonym: "retention of lipids" EXACT [GOC:dph, GOC:tb]
synonym: "sequestering of lipids" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of lipid" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of lipids" EXACT [GOC:dph, GOC:tb]
synonym: "storage of lipids" EXACT []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0010876 ! lipid localization

[Term]
id: GO:0019916
name: obsolete peptidyl-D-alanine racemization, direct
namespace: biological_process
def: "OBSOLETE. The racemization of peptidyl-alanine." [RESID:AA0191]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019917
name: obsolete peptidyl-D-alanine racemization via peptidyl-L-serine
namespace: biological_process
def: "OBSOLETE. The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019918
name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine
namespace: biological_process
def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0067
xref: RESID:AA0069
is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation

[Term]
id: GO:0019919
name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
namespace: biological_process
def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069]
subset: gocheck_obsoletion_candidate
synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT []
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation

[Term]
id: GO:0019920
name: obsolete peptidyl-1-thioglycine biosynthetic process, internal
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, PMID:10660523, RESID:AA0265]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT []
synonym: "peptidyl-1-thioglycine formation, internal" EXACT []
synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT []
is_obsolete: true

[Term]
id: GO:0019921
name: obsolete peptidyl-1-thioglycine biosynthetic process, carboxy-terminal
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, PMID:10660523, RESID:AA0265]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT []
synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT []
synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT []
is_obsolete: true

[Term]
id: GO:0019922
name: obsolete protein-chromophore linkage via peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma]
comment: Term describes modified products or self-catalyzed processes.
is_obsolete: true

[Term]
id: GO:0019923
name: obsolete alpha-1-microglobulin-chromophore linkage
namespace: biological_process
def: "OBSOLETE. The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224]
comment: Term describes modified products or self-catalyzed processes.
xref: RESID:AA0224
is_obsolete: true

[Term]
id: GO:0019926
name: obsolete peptidyl-tryptophan oxidation to tryptophyl quinone
namespace: biological_process
def: "OBSOLETE. The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148]
comment: This term was obsoleted because it represents a cofactor, see PMID:2028257.
is_obsolete: true

[Term]
id: GO:0019927
name: obsolete peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone
namespace: biological_process
def: "OBSOLETE. The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0313
is_obsolete: true

[Term]
id: GO:0019928
name: obsolete peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid
namespace: biological_process
def: "OBSOLETE. The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0314
is_obsolete: true

[Term]
id: GO:0019929
name: obsolete peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid
namespace: biological_process
def: "OBSOLETE. The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0315
is_obsolete: true

[Term]
id: GO:0019930
name: obsolete cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT []
is_obsolete: true

[Term]
id: GO:0019931
name: obsolete protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312]
comment: Term describes modified products or self-catalyzed processes.
xref: RESID:AA0312
is_obsolete: true

[Term]
id: GO:0019932
name: obsolete second-messenger-mediated signaling
namespace: biological_process
def: "OBSOLETE. Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell." [GOC:signaling, ISBN:0815316194, PMID:15221855, Wikipedia:Second_messenger_system]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "second messenger mediated signaling" EXACT []
synonym: "second messenger mediated signalling" EXACT []
synonym: "second messenger-mediated signaling" EXACT []
synonym: "second messenger-mediated signalling" EXACT []
synonym: "second-messenger-mediated signal transduction" EXACT [GOC:signaling]
synonym: "second-messenger-mediated signalling" EXACT []
is_obsolete: true
consider: GO:0007263
consider: GO:0019722
consider: GO:0019933
consider: GO:0019934

[Term]
id: GO:0019933
name: cAMP-mediated signaling
namespace: biological_process
def: "An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling]
synonym: "3',5' cAMP-mediated signaling" EXACT []
synonym: "3',5' cAMP-mediated signalling" EXACT []
synonym: "3',5'-cAMP-mediated signaling" EXACT []
synonym: "3',5'-cAMP-mediated signalling" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT []
synonym: "cAMP signaling" EXACT []
synonym: "cAMP signalling" EXACT []
synonym: "cAMP-mediated signal transduction" EXACT []
synonym: "cAMP-mediated signalling" EXACT []
synonym: "cyclic AMP-mediated signaling" EXACT []
synonym: "cyclic AMP-mediated signalling" EXACT []
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0019934
name: cGMP-mediated signaling
namespace: biological_process
def: "An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling]
synonym: "cGMP-mediated signalling" EXACT []
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0019935
name: obsolete cyclic-nucleotide-mediated signaling
namespace: biological_process
def: "OBSOLETE. An intracellular signaling cassette that starts with production or release of the cyclic nucleotide, and ends with the activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "cyclic-nucleotide-mediated signalling" EXACT []
is_obsolete: true
consider: GO:0019933
consider: GO:0038060

[Term]
id: GO:0019936
name: obsolete inositol phospholipid-mediated signaling
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ceb]
comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling.
synonym: "inositol phospholipid-mediated signaling" EXACT []
synonym: "inositol phospholipid-mediated signalling" EXACT []
is_obsolete: true
consider: GO:0035556

[Term]
id: GO:0019937
name: obsolete protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic
namespace: biological_process
def: "OBSOLETE. The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019938
name: obsolete peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic
namespace: biological_process
alt_id: GO:0042266
def: "OBSOLETE. The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0019939
name: obsolete peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0019940
name: obsolete SUMO-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein.
synonym: "SUMO-dependent protein breakdown" EXACT []
synonym: "SUMO-dependent protein catabolic process" EXACT []
synonym: "SUMO-dependent protein catabolism" EXACT []
synonym: "SUMO-dependent protein degradation" EXACT []
is_obsolete: true
consider: GO:0016925
consider: GO:0016926

[Term]
id: GO:0019941
name: modification-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]
synonym: "modification-dependent protein breakdown" EXACT []
synonym: "modification-dependent protein catabolism" EXACT []
synonym: "modification-dependent protein degradation" EXACT []
synonym: "modification-dependent proteolysis" EXACT [GOC:rl]
synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl]
synonym: "modification-initiated protein catabolism" EXACT [GOC:rl]
synonym: "modification-initiated proteolysis" EXACT [GOC:rl]
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein-ligand-dependent protein catabolic process" NARROW []
synonym: "protein-ligand-dependent protein catabolism" NARROW []
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process
is_a: GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:0019942
name: obsolete NEDD8 class-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl]
comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction.
synonym: "NEDD8 class-dependent protein breakdown" EXACT []
synonym: "NEDD8 class-dependent protein catabolic process" EXACT []
synonym: "NEDD8 class-dependent protein catabolism" EXACT []
synonym: "NEDD8 class-dependent protein degradation" EXACT []
synonym: "RUB1-dependent protein catabolic process" EXACT []
synonym: "RUB1-dependent protein catabolism" EXACT []
synonym: "RUB1-dependent protein degradation" EXACT []
is_obsolete: true
consider: GO:0045116

[Term]
id: GO:0019948
name: SUMO activating enzyme activity
namespace: molecular_function
alt_id: GO:0017115
def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250]
synonym: "SMT3 activating enzyme" EXACT []
synonym: "SUMO E1 activator enzyme" EXACT []
xref: Reactome:R-HSA-2990833 "Conjugation of SUMO1 to UBA2:SAE1"
xref: Reactome:R-HSA-2993781 "Conjugation of SUMO3 to UBA2:SAE1"
xref: Reactome:R-HSA-2993784 "Conjugation of SUMO2 to UBA2:SAE1"
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0019950
name: obsolete SMT3-dependent protein catabolic process
namespace: biological_process
alt_id: GO:0019946
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231]
comment: See issue #21890. SMT3 protein mod is sumoylation and does not always lead to degradation.
synonym: "SMT3-dependent protein breakdown" EXACT []
synonym: "SMT3-dependent protein catabolism" EXACT []
synonym: "SMT3-dependent protein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0019953
name: sexual reproduction
namespace: biological_process
def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction]
comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.
xref: Wikipedia:Sexual_reproduction
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0019954
name: asexual reproduction
namespace: biological_process
def: "A type of reproduction in which new individuals are produced from a single organism, either from an unfertilized egg or from a single cell or group of cells." [ISBN:0387520546, PMID:22977071, PMID:28779329, PMID:29559496]
synonym: "parthenogenesis" RELATED [Wikipedia:Parthenogenesis]
xref: Wikipedia:Asexual_reproduction
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0019955
name: cytokine binding
namespace: molecular_function
alt_id: GO:0019965
def: "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
synonym: "IL binding" NARROW []
synonym: "interleukin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019956
name: chemokine binding
namespace: molecular_function
def: "Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:ai, GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019957
name: C-C chemokine binding
namespace: molecular_function
def: "Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019958
name: C-X-C chemokine binding
namespace: molecular_function
def: "Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019959
name: interleukin-8 binding
namespace: molecular_function
def: "Binding to interleukin-8." [GOC:jl]
synonym: "IL-8 binding" EXACT []
is_a: GO:0019958 ! C-X-C chemokine binding

[Term]
id: GO:0019960
name: C-X3-C chemokine binding
namespace: molecular_function
def: "Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019961
name: interferon binding
namespace: molecular_function
def: "Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [PMID:9607096, Wikipedia:Interferon]
synonym: "IFN binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019962
name: type I interferon binding
namespace: molecular_function
def: "Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon-alpha binding" NARROW []
synonym: "interferon-alpha/beta binding" NARROW []
synonym: "interferon-beta binding" NARROW []
synonym: "interferon-delta binding" NARROW []
synonym: "interferon-epsilon binding" NARROW []
synonym: "interferon-kappa binding" NARROW []
synonym: "interferon-omega binding" NARROW []
synonym: "interferon-tau binding" NARROW []
synonym: "interferon-zeta binding" NARROW []
synonym: "type I IFN binding" EXACT [GOC:mah]
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0019964
name: type II interferon binding
namespace: molecular_function
def: "Binding to type II interferon, also known as interferon-gamma." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383]
synonym: "IFN-gamma binding" EXACT [GOC:mah]
synonym: "IFNG binding" EXACT [GOC:mah]
synonym: "interferon-gamma binding" BROAD [PMID:15546383, PR:000024990]
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0019966
name: interleukin-1 binding
namespace: molecular_function
def: "Binding to interleukin-1." [GOC:jl, ISBN:0198506732]
synonym: "IL-1 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019969
name: interleukin-10 binding
namespace: molecular_function
def: "Binding to interleukin-10." [GOC:jl]
synonym: "IL-10 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019970
name: interleukin-11 binding
namespace: molecular_function
def: "Binding to interleukin-11." [GOC:jl]
synonym: "IL-11 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019972
name: interleukin-12 binding
namespace: molecular_function
def: "Binding to interleukin-12." [GOC:jl]
synonym: "IL-12 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019973
name: interleukin-13 binding
namespace: molecular_function
def: "Binding to interleukin-13." [GOC:jl]
synonym: "IL-13 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019974
name: obsolete interleukin-14 binding
namespace: molecular_function
def: "OBSOLETE. Binding to interleukin-14." [GOC:jl]
comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
synonym: "IL-14 binding" EXACT []
is_obsolete: true

[Term]
id: GO:0019975
name: interleukin-17 binding
namespace: molecular_function
def: "Binding to a member of the interleukin-17 family of cytokines." [GOC:add, GOC:jl]
synonym: "IL-17 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019976
name: interleukin-2 binding
namespace: molecular_function
def: "Binding to interleukin-2." [GOC:jl]
synonym: "IL-2 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019977
name: interleukin-21 binding
namespace: molecular_function
def: "Binding to interleukin-21." [GOC:jl]
synonym: "IL-21 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019978
name: interleukin-3 binding
namespace: molecular_function
def: "Binding to interleukin-3." [GOC:jl]
synonym: "IL-3 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019979
name: interleukin-4 binding
namespace: molecular_function
def: "Binding to interleukin-4." [GOC:jl]
synonym: "IL-4 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019980
name: interleukin-5 binding
namespace: molecular_function
def: "Binding to interleukin-5." [GOC:jl]
synonym: "IL-5 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019981
name: interleukin-6 binding
namespace: molecular_function
def: "Binding to interleukin-6." [GOC:jl]
synonym: "IL-6 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019982
name: interleukin-7 binding
namespace: molecular_function
def: "Binding to interleukin-7." [GOC:jl]
synonym: "IL-7 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019983
name: interleukin-9 binding
namespace: molecular_function
def: "Binding to interleukin-9." [GOC:jl]
synonym: "IL-9 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019985
name: translesion synthesis
namespace: biological_process
def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]
synonym: "bypass DNA synthesis" EXACT [GOC:elh]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
is_a: GO:0006301 ! postreplication repair

[Term]
id: GO:0019987
name: obsolete negative regulation of anti-apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis]
comment: This term was made obsolete because it was ill-defined.
synonym: "down regulation of anti-apoptosis" EXACT []
synonym: "down-regulation of anti-apoptosis" EXACT []
synonym: "downregulation of anti-apoptosis" EXACT []
synonym: "inhibition of anti-apoptosis" NARROW []
synonym: "negative regulation of anti-apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0019988
name: charged-tRNA amino acid modification
namespace: biological_process
alt_id: GO:0030630
def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg]
synonym: "charged tRNA amino acid modification" EXACT []
synonym: "charged tRNA modification" EXACT []
synonym: "charged-tRNA modification" RELATED []
synonym: "pre-translational amino acid modification" EXACT []
synonym: "pre-translational protein modification" EXACT []
synonym: "pretranslation protein modification" EXACT []
synonym: "pretranslational amino acid modification" EXACT []
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0019990
name: pteridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
synonym: "pteridine breakdown" EXACT []
synonym: "pteridine catabolism" EXACT []
synonym: "pteridine degradation" EXACT []
is_a: GO:0019889 ! pteridine metabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process

[Term]
id: GO:0019991
name: septate junction assembly
namespace: biological_process
def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
is_a: GO:0120192 ! tight junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0019992
name: diacylglycerol binding
namespace: molecular_function
def: "Binding to a diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma]
xref: Reactome:R-HSA-400015 "Diacylgycerol activates Protein kinase C, alpha type"
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0020002
name: host cell plasma membrane
namespace: cellular_component
def: "The plasma membrane surrounding a host cell." [GOC:mb]
subset: goslim_virus
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0020003
name: symbiont-containing vacuole
namespace: cellular_component
def: "Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont." [GOC:jl, GOC:mb]
comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope.
subset: goslim_virus
synonym: "bacterium-containing vacuole" NARROW [PMID:22042847]
synonym: "parasitophorous vacuole" EXACT []
synonym: "pathogen-occupied vacuole" NARROW [PMID:24034612]
synonym: "Salmonella-containing vacuole" NARROW [PMID:10449405, PMID:15121880]
synonym: "SCV" EXACT [PMID:10449405, PMID:15121880]
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0065010 ! extracellular membrane-bounded organelle

[Term]
id: GO:0020004
name: symbiont-containing vacuolar space
namespace: cellular_component
def: "The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane." [GOC:jl, GOC:mb]
synonym: "parasitophorous vacuolar space" EXACT []
synonym: "symbiont-containing vacuole space" RELATED []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0020003 ! symbiont-containing vacuole

[Term]
id: GO:0020005
name: symbiont-containing vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont." [GOC:jl, GOC:mb]
synonym: "parasitophorous vacuolar membrane" EXACT []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0020003 ! symbiont-containing vacuole

[Term]
id: GO:0020006
name: symbiont-containing vacuolar membrane network
namespace: cellular_component
def: "Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm." [GOC:jl, PMID:3528173]
synonym: "parasitophorous vacuolar membrane network" EXACT []
synonym: "symbiont-containing vacuole membrane network" EXACT []
synonym: "tubulovesicular network" NARROW []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane

[Term]
id: GO:0020007
name: apical complex
namespace: cellular_component
def: "A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation." [GOC:giardia, GOC:mb, PMID:16518471]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0020008
name: rhoptry
namespace: cellular_component
def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398]
synonym: "paired organelles" RELATED []
synonym: "toxoneme" RELATED []
xref: Wikipedia:Rhoptry
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020009
name: microneme
namespace: cellular_component
def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218]
synonym: "sarconeme" RELATED []
xref: Wikipedia:Microneme
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020010
name: conoid
namespace: cellular_component
def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules." [GOC:expert_dr, PMID:11901169, PMID:16518471]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020011
name: apicoplast
namespace: cellular_component
def: "The plastid organelle found in apicomplexans." [ISBN:0521664470]
xref: Wikipedia:Apicoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0020013
name: symbiont-mediated perturbation of host erythrocyte aggregation
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes." [GOC:add, GOC:dgh, GOC:mb, GOC:pr, PMID:19467172, PMID:21305024]
comment: Please note that this term does not refer to the in vitro assay called erythrocyte rosetting.
synonym: "modulation by symbiont of host erythrocyte aggregation" EXACT []
synonym: "rosetting" EXACT []
xref: Wikipedia:Rosetting
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0020014
name: schizogony
namespace: biological_process
def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb]
xref: Wikipedia:Protozoal_merogony
is_a: GO:0051301 ! cell division

[Term]
id: GO:0020015
name: glycosome
namespace: cellular_component
def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb]
subset: goslim_pir
xref: Wikipedia:Glycosome
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0020016
name: ciliary pocket
namespace: cellular_component
def: "Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes." [GOC:cilia, GOC:mb]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage.
synonym: "cilial pocket" EXACT []
synonym: "cilium pocket" EXACT []
synonym: "flagellar pocket" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0020018
name: ciliary pocket membrane
namespace: cellular_component
def: "That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket)." [GOC:cilia, GOC:mb]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage.
synonym: "cilial pocket membrane" EXACT []
synonym: "cilium pocket membrane" EXACT []
synonym: "flagellar pocket membrane" EXACT []
is_a: GO:0060170 ! ciliary membrane
relationship: part_of GO:0020016 ! ciliary pocket

[Term]
id: GO:0020020
name: food vacuole
namespace: cellular_component
alt_id: GO:0005772
def: "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa." [GOC:mb]
synonym: "digestive vacuole" EXACT []
is_a: GO:0032010 ! phagolysosome

[Term]
id: GO:0020022
name: acidocalcisome
namespace: cellular_component
def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb]
subset: goslim_pir
synonym: "metachromatic granule" EXACT [PMID:15738951]
synonym: "polyphosphate vacuole" RELATED [PMID:15738951]
synonym: "volutin granule" EXACT [PMID:15738951]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0020023
name: kinetoplast
namespace: cellular_component
def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb]
xref: Wikipedia:Kinetoplast
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0020025
name: subpellicular microtubule
namespace: cellular_component
def: "Singlet microtubule that lie underneath the inner membrane pellicle complex and emanate from the basal ring of the conoid." [GOC:mb, PMID:24800253]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020026
name: merozoite dense granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu]
synonym: "dense body" RELATED []
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0020027
name: hemoglobin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl]
synonym: "haemoglobin metabolic process" EXACT []
synonym: "haemoglobin metabolism" EXACT []
synonym: "hemoglobin metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0020028
name: endocytic hemoglobin import into cell
namespace: biological_process
def: "The directed movement of hemoglobin into a cell by receptor-mediated endocytosis." [GOC:mb]
synonym: "endocytic hemoglobin import" RELATED []
synonym: "haemoglobin uptake" EXACT []
synonym: "hemoglobin uptake" EXACT []
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0015031 ! protein transport
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0020030
name: infected host cell surface knob
namespace: cellular_component
def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species." [GOC:mb]
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0020031
name: polar ring of apical complex
namespace: cellular_component
def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471]
synonym: "anterior polar ring of apical complex" EXACT []
synonym: "upper polar ring of apical complex" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020032
name: basal ring of apical complex
namespace: cellular_component
def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471]
synonym: "lower polar ring of apical complex" EXACT []
synonym: "posterior polar ring of apical complex" EXACT []
synonym: "preconoidal ring of apical complex" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020033
name: antigenic variation
namespace: biological_process
alt_id: GO:0020034
def: "A process by which a symbiont evades the host adaptive immune response by changing antigenic determinants on the symbiont surface that are exposed to host antibodies." [PMID:29116635, PMID:37524976]
synonym: "surface antigen variation" NARROW []
xref: Wikipedia:Antigenic_variation
is_a: GO:0042783 ! symbiont-mediated evasion of host immune response

[Term]
id: GO:0020035
name: adhesion of symbiont to microvasculature
namespace: biological_process
alt_id: GO:0043706
def: "The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte." [GOC:mb, PMID:10362584]
synonym: "cytoadherence to microvasculature, mediated by parasite protein" NARROW []
synonym: "cytoadherence to microvasculature, mediated by symbiont protein" EXACT []
synonym: "heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein" NARROW []
synonym: "parasite-protein-mediated cytoadherence to microvasculature" NARROW []
synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD []
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0020036
name: Maurer's cleft
namespace: cellular_component
def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161]
synonym: "Maurers cleft" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0020037
name: heme binding
namespace: molecular_function
def: "Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]
synonym: "haem binding" EXACT []
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0020038
name: subpellicular network
namespace: cellular_component
def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0020039
name: pellicle
namespace: cellular_component
def: "The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mah, GOC:mb]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0021501
name: prechordal plate formation
namespace: biological_process
def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0021502
name: neural fold elevation formation
namespace: biological_process
def: "The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001842 ! neural fold formation

[Term]
id: GO:0021503
name: neural fold bending
namespace: biological_process
def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001842 ! neural fold formation

[Term]
id: GO:0021504
name: neural fold hinge point formation
namespace: biological_process
def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]
synonym: "neural fold furrowing" NARROW [GOC:cls]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021503 ! neural fold bending

[Term]
id: GO:0021505
name: neural fold folding
namespace: biological_process
def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0021503 ! neural fold bending

[Term]
id: GO:0021506
name: anterior neuropore closure
namespace: biological_process
def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0021995 ! neuropore closure

[Term]
id: GO:0021507
name: posterior neuropore closure
namespace: biological_process
def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0060608 ! cell-cell adhesion involved in neural tube closure
relationship: part_of GO:0021995 ! neuropore closure

[Term]
id: GO:0021508
name: floor plate formation
namespace: biological_process
def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007418 ! ventral midline development
relationship: part_of GO:0033505 ! floor plate morphogenesis

[Term]
id: GO:0021509
name: roof plate formation
namespace: biological_process
def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0021510
name: spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021511
name: spinal cord patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021512
name: spinal cord anterior/posterior patterning
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "spinal cord anterior-posterior patterning" EXACT []
synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0021511 ! spinal cord patterning

[Term]
id: GO:0021513
name: spinal cord dorsal/ventral patterning
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "spinal cord dorsal-ventral patterning" EXACT []
synonym: "spinal cord dorsoventral patterning" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021511 ! spinal cord patterning

[Term]
id: GO:0021514
name: ventral spinal cord interneuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021517 ! ventral spinal cord development

[Term]
id: GO:0021515
name: cell differentiation in spinal cord
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021516
name: dorsal spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11179871]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021517
name: ventral spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021518
name: spinal cord commissural neuron specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021528 ! commissural neuron differentiation in spinal cord

[Term]
id: GO:0021519
name: spinal cord association neuron specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021527 ! spinal cord association neuron differentiation

[Term]
id: GO:0021520
name: spinal cord motor neuron cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021521
name: ventral spinal cord interneuron specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048665 ! neuron fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment

[Term]
id: GO:0021522
name: spinal cord motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021517 ! ventral spinal cord development

[Term]
id: GO:0021523
name: somatic motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021524
name: visceral motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021525
name: lateral motor column neuron differentiation
namespace: biological_process
def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021522 ! spinal cord motor neuron differentiation
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021526
name: medial motor column neuron differentiation
namespace: biological_process
def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021527
name: spinal cord association neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021516 ! dorsal spinal cord development

[Term]
id: GO:0021528
name: commissural neuron differentiation in spinal cord
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation

[Term]
id: GO:0021529
name: spinal cord oligodendrocyte cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0021530
name: spinal cord oligodendrocyte cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021778 ! oligodendrocyte cell fate specification
relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation

[Term]
id: GO:0021531
name: spinal cord radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16185248]
synonym: "radial glial cell differentiation in spinal cord" EXACT []
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0060019 ! radial glial cell differentiation

[Term]
id: GO:0021532
name: neural tube patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0021533
name: cell differentiation in hindbrain
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021534
name: cell proliferation in hindbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021535
name: cell migration in hindbrain
namespace: biological_process
def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021536
name: diencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021537
name: telencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021538
name: epithalamus development
namespace: biological_process
def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021539
name: subthalamus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "ventral thalamus development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021540
name: corpus callosum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0022038 ! corpus callosum development

[Term]
id: GO:0021541
name: ammon gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "Ammon's horn development" RELATED [GOC:cls]
synonym: "cornu ammonis development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021766 ! hippocampus development

[Term]
id: GO:0021542
name: dentate gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021766 ! hippocampus development

[Term]
id: GO:0021543
name: pallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021544
name: subpallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021545
name: cranial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0021675 ! nerve development

[Term]
id: GO:0021546
name: rhombomere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021547
name: midbrain-hindbrain boundary initiation
namespace: biological_process
def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513]
synonym: "isthmus biosynthesis" RELATED [GOC:cls]
synonym: "isthmus formation" RELATED [GOC:cls]
synonym: "MHB biosynthesis" EXACT [GOC:cls]
synonym: "MHB formation" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls]
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021548
name: pons development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0022037 ! metencephalon development

[Term]
id: GO:0021549
name: cerebellum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0022037 ! metencephalon development

[Term]
id: GO:0021550
name: medulla oblongata development
namespace: biological_process
def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla development" RELATED [GOC:cls]
synonym: "myelencephalon development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021551
name: central nervous system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021552
name: midbrain-hindbrain boundary structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus structural organization" RELATED [GOC:cls]
synonym: "MHB structural organization" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis

[Term]
id: GO:0021553
name: olfactory nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN 1 development" RELATED [GOC:cls]
synonym: "cranial nerve 1 development" EXACT [GOC:cls]
synonym: "cranial nerve I development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021554
name: optic nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN II development" RELATED [GOC:cls]
synonym: "cranial nerve 2 development" EXACT [GOC:cls]
synonym: "cranial nerve II development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021555
name: midbrain-hindbrain boundary morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus morphogenesis" EXACT [GOC:cls]
synonym: "MHB morphogenesis" EXACT [GOC:cls]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021556
name: central nervous system formation
namespace: biological_process
def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021551 ! central nervous system morphogenesis

[Term]
id: GO:0021557
name: oculomotor nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN III development" RELATED [GOC:cls]
synonym: "cranial nerve 3 development" EXACT [GOC:cls]
synonym: "cranial nerve III development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development

[Term]
id: GO:0021558
name: trochlear nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IV development" RELATED [GOC:cls]
synonym: "cranial nerve 4 development" EXACT [GOC:cls]
synonym: "cranial nerve IV development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021559
name: trigeminal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V development" RELATED [GOC:cls]
synonym: "cranial nerve 5 development" EXACT [GOC:cls]
synonym: "cranial nerve V development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021560
name: abducens nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VI development" RELATED [GOC:cls]
synonym: "cranial nerve 6 development" EXACT [GOC:cls]
synonym: "cranial nerve VI development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021561
name: facial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VII development" RELATED [GOC:cls]
synonym: "cranial nerve 7 development" EXACT [GOC:cls]
synonym: "cranial nerve VII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development

[Term]
id: GO:0021562
name: vestibulocochlear nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "acoustic nerve development" EXACT [PMID:11533729]
synonym: "CN VIII development" EXACT [GOC:cls]
synonym: "cranial nerve 8 development" EXACT [GOC:cls]
synonym: "cranial nerve VIII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021563
name: glossopharyngeal nerve development
namespace: biological_process
def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX development" RELATED [GOC:cls]
synonym: "cranial nerve 9 development" EXACT [GOC:cls]
synonym: "cranial nerve IX development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021564
name: vagus nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X development" RELATED [GOC:cls]
synonym: "cranial nerve 10 development" RELATED [GOC:cls]
synonym: "cranial nerve X development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development

[Term]
id: GO:0021565
name: accessory nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI development" RELATED [GOC:cls]
synonym: "cranial nerve 11 development" RELATED [GOC:cls]
synonym: "cranial nerve XI development" EXACT [GOC:cls]
synonym: "spinal accessory nerve development" EXACT [PMID:11533729]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021566
name: hypoglossal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII development" RELATED [GOC:cls]
synonym: "cranial nerve 12 development" RELATED [GOC:cls]
synonym: "cranial nerve XII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021567
name: rhombomere 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021568
name: rhombomere 2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021569
name: rhombomere 3 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021570
name: rhombomere 4 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021571
name: rhombomere 5 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021572
name: rhombomere 6 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021573
name: rhombomere 7 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021574
name: rhombomere 8 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021575
name: hindbrain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "rhombencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021576
name: hindbrain formation
namespace: biological_process
def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021577
name: hindbrain structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "hindbrain structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021578
name: hindbrain maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021626 ! central nervous system maturation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021579
name: medulla oblongata morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla morphogenesis" RELATED []
synonym: "myelencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021580
name: medulla oblongata formation
namespace: biological_process
def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla biosynthesis" RELATED []
synonym: "medulla formation" RELATED []
synonym: "myelencephalon biosynthesis" RELATED []
synonym: "myelencephalon formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis

[Term]
id: GO:0021581
name: medulla oblongata structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla oblongata structural organisation" EXACT [GOC:mah]
synonym: "medulla structural maturation" RELATED []
synonym: "myelencephalon structural maturation" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis

[Term]
id: GO:0021582
name: medulla oblongata maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla maturation" RELATED []
synonym: "myelencephalon maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021583
name: pons morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021584
name: pons formation
namespace: biological_process
def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021583 ! pons morphogenesis

[Term]
id: GO:0021585
name: pons structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "pons structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021583 ! pons morphogenesis

[Term]
id: GO:0021586
name: pons maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021587
name: cerebellum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021588
name: cerebellum formation
namespace: biological_process
def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021587 ! cerebellum morphogenesis

[Term]
id: GO:0021589
name: cerebellum structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "cerebellum structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021587 ! cerebellum morphogenesis

[Term]
id: GO:0021590
name: cerebellum maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021591
name: ventricular system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0021592
name: fourth ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021591 ! ventricular system development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021593
name: rhombomere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0021594
name: rhombomere formation
namespace: biological_process
def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021593 ! rhombomere morphogenesis

[Term]
id: GO:0021595
name: rhombomere structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "rhombomere structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021593 ! rhombomere morphogenesis

[Term]
id: GO:0021597
name: central nervous system structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
synonym: "central nervous system structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021551 ! central nervous system morphogenesis

[Term]
id: GO:0021598
name: abducens nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VI development" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021560 ! abducens nerve development

[Term]
id: GO:0021599
name: abducens nerve formation
namespace: biological_process
def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VI biosynthesis" RELATED []
synonym: "CN VI formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021598 ! abducens nerve morphogenesis

[Term]
id: GO:0021600
name: abducens nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "abducens nerve structural organisation" EXACT [GOC:mah]
synonym: "CN VI structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021598 ! abducens nerve morphogenesis

[Term]
id: GO:0021601
name: abducens nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VI maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021560 ! abducens nerve development

[Term]
id: GO:0021602
name: cranial nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021545 ! cranial nerve development

[Term]
id: GO:0021603
name: cranial nerve formation
namespace: biological_process
def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021602 ! cranial nerve morphogenesis

[Term]
id: GO:0021604
name: cranial nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "cranial nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021602 ! cranial nerve morphogenesis

[Term]
id: GO:0021605
name: cranial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0021682 ! nerve maturation
relationship: part_of GO:0021545 ! cranial nerve development

[Term]
id: GO:0021606
name: accessory nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI maturation" RELATED []
synonym: "spinal accessory nerve maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021565 ! accessory nerve development

[Term]
id: GO:0021607
name: accessory nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021565 ! accessory nerve development

[Term]
id: GO:0021608
name: accessory nerve formation
namespace: biological_process
def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI biosynthesis" RELATED []
synonym: "CN XI formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021607 ! accessory nerve morphogenesis

[Term]
id: GO:0021609
name: accessory nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "accessory nerve structural organisation" EXACT [GOC:mah]
synonym: "CN XI structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021607 ! accessory nerve morphogenesis

[Term]
id: GO:0021610
name: facial nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021561 ! facial nerve development

[Term]
id: GO:0021611
name: facial nerve formation
namespace: biological_process
def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VII biosynthesis" RELATED []
synonym: "CN VII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021610 ! facial nerve morphogenesis

[Term]
id: GO:0021612
name: facial nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VII structural organization" RELATED []
synonym: "facial nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021610 ! facial nerve morphogenesis

[Term]
id: GO:0021613
name: facial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021561 ! facial nerve development

[Term]
id: GO:0021614
name: glossopharyngeal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021563 ! glossopharyngeal nerve development

[Term]
id: GO:0021615
name: glossopharyngeal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021563 ! glossopharyngeal nerve development

[Term]
id: GO:0021616
name: glossopharyngeal nerve formation
namespace: biological_process
def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX biosynthesis" RELATED []
synonym: "CN IX formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis

[Term]
id: GO:0021617
name: glossopharyngeal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX structural organization" RELATED []
synonym: "glossopharyngeal nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis

[Term]
id: GO:0021618
name: hypoglossal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021566 ! hypoglossal nerve development

[Term]
id: GO:0021619
name: hypoglossal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021566 ! hypoglossal nerve development

[Term]
id: GO:0021620
name: hypoglossal nerve formation
namespace: biological_process
def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII biosynthesis" RELATED []
synonym: "CN XII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis

[Term]
id: GO:0021621
name: hypoglossal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII structural organization" RELATED []
synonym: "hypoglossal nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis

[Term]
id: GO:0021622
name: oculomotor nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN III morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021557 ! oculomotor nerve development

[Term]
id: GO:0021623
name: oculomotor nerve formation
namespace: biological_process
def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN III biosynthesis" RELATED []
synonym: "CN III formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis

[Term]
id: GO:0021624
name: oculomotor nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN III structural organization" RELATED []
synonym: "oculomotor nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis

[Term]
id: GO:0021625
name: oculomotor nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN III maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021557 ! oculomotor nerve development

[Term]
id: GO:0021626
name: central nervous system maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021627
name: olfactory nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN I morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021553 ! olfactory nerve development

[Term]
id: GO:0021628
name: olfactory nerve formation
namespace: biological_process
def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN I biosynthesis" RELATED []
synonym: "CN I formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021627 ! olfactory nerve morphogenesis

[Term]
id: GO:0021629
name: olfactory nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN I structural organization" RELATED []
synonym: "olfactory nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021627 ! olfactory nerve morphogenesis

[Term]
id: GO:0021630
name: olfactory nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "CN I maturation" EXACT []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021553 ! olfactory nerve development

[Term]
id: GO:0021631
name: optic nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN II morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021554 ! optic nerve development

[Term]
id: GO:0021632
name: optic nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN II maturation" EXACT []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021554 ! optic nerve development

[Term]
id: GO:0021633
name: optic nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN II structural organization" RELATED []
synonym: "optic nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021631 ! optic nerve morphogenesis

[Term]
id: GO:0021634
name: optic nerve formation
namespace: biological_process
def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN II biosynthesis" RELATED []
synonym: "CN II formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021631 ! optic nerve morphogenesis

[Term]
id: GO:0021635
name: trigeminal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021559 ! trigeminal nerve development

[Term]
id: GO:0021636
name: trigeminal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021559 ! trigeminal nerve development

[Term]
id: GO:0021637
name: trigeminal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V structural organization" RELATED []
synonym: "trigeminal nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis

[Term]
id: GO:0021638
name: trigeminal nerve formation
namespace: biological_process
def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V biosynthesis" RELATED []
synonym: "CN V formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis

[Term]
id: GO:0021639
name: trochlear nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CH IV morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021558 ! trochlear nerve development

[Term]
id: GO:0021640
name: trochlear nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IV maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021558 ! trochlear nerve development

[Term]
id: GO:0021641
name: trochlear nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IV structural organization" RELATED []
synonym: "trochlear nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021639 ! trochlear nerve morphogenesis

[Term]
id: GO:0021642
name: trochlear nerve formation
namespace: biological_process
def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IV biosynthesis" RELATED []
synonym: "CN IV formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021639 ! trochlear nerve morphogenesis

[Term]
id: GO:0021643
name: vagus nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021564 ! vagus nerve development

[Term]
id: GO:0021644
name: vagus nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021564 ! vagus nerve development

[Term]
id: GO:0021645
name: vagus nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X structural organization" RELATED []
synonym: "vagus nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021644 ! vagus nerve morphogenesis

[Term]
id: GO:0021646
name: vagus nerve formation
namespace: biological_process
def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X biosynthesis" RELATED []
synonym: "CN X formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021644 ! vagus nerve morphogenesis

[Term]
id: GO:0021647
name: vestibulocochlear nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "auditory nerve maturation" RELATED []
synonym: "CN VIII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021562 ! vestibulocochlear nerve development

[Term]
id: GO:0021648
name: vestibulocochlear nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VIII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021562 ! vestibulocochlear nerve development

[Term]
id: GO:0021649
name: vestibulocochlear nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VII structural organization" RELATED []
synonym: "vestibulocochlear nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis

[Term]
id: GO:0021650
name: vestibulocochlear nerve formation
namespace: biological_process
def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN VII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis

[Term]
id: GO:0021651
name: rhombomere 1 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021567 ! rhombomere 1 development

[Term]
id: GO:0021652
name: rhombomere 1 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis

[Term]
id: GO:0021653
name: rhombomere 1 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 1 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis

[Term]
id: GO:0021654
name: rhombomere boundary formation
namespace: biological_process
def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021594 ! rhombomere formation

[Term]
id: GO:0021655
name: rhombomere 2 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021568 ! rhombomere 2 development

[Term]
id: GO:0021656
name: rhombomere 2 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 2 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis

[Term]
id: GO:0021657
name: rhombomere 2 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis

[Term]
id: GO:0021658
name: rhombomere 3 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021569 ! rhombomere 3 development

[Term]
id: GO:0021659
name: rhombomere 3 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 3 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis

[Term]
id: GO:0021660
name: rhombomere 3 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis

[Term]
id: GO:0021661
name: rhombomere 4 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021570 ! rhombomere 4 development

[Term]
id: GO:0021662
name: rhombomere 4 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 4 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis

[Term]
id: GO:0021663
name: rhombomere 4 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis

[Term]
id: GO:0021664
name: rhombomere 5 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021571 ! rhombomere 5 development

[Term]
id: GO:0021665
name: rhombomere 5 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 5 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis

[Term]
id: GO:0021666
name: rhombomere 5 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis

[Term]
id: GO:0021667
name: rhombomere 6 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021572 ! rhombomere 6 development

[Term]
id: GO:0021668
name: rhombomere 6 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 6 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis

[Term]
id: GO:0021669
name: rhombomere 6 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis

[Term]
id: GO:0021670
name: lateral ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development
relationship: part_of GO:0021591 ! ventricular system development

[Term]
id: GO:0021671
name: rhombomere 7 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021573 ! rhombomere 7 development

[Term]
id: GO:0021672
name: rhombomere 7 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 7 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis

[Term]
id: GO:0021673
name: rhombomere 7 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis

[Term]
id: GO:0021674
name: rhombomere 8 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021574 ! rhombomere 8 development

[Term]
id: GO:0021675
name: nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0021676
name: rhombomere 8 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rhombomere 8 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis

[Term]
id: GO:0021677
name: rhombomere 8 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis

[Term]
id: GO:0021678
name: third ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021591 ! ventricular system development

[Term]
id: GO:0021679
name: cerebellar molecular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021680
name: cerebellar Purkinje cell layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021681
name: cerebellar granular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021682
name: nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021675 ! nerve development

[Term]
id: GO:0021683
name: cerebellar granular layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021681 ! cerebellar granular layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021684
name: cerebellar granular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021685
name: cerebellar granular layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "cerebellar granular layer structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021686
name: cerebellar granular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021681 ! cerebellar granular layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021687
name: cerebellar molecular layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021679 ! cerebellar molecular layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021688
name: cerebellar molecular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021689
name: cerebellar molecular layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "cerebellar molecular layer structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021690
name: cerebellar molecular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021679 ! cerebellar molecular layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021691
name: cerebellar Purkinje cell layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021692
name: cerebellar Purkinje cell layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021693
name: cerebellar Purkinje cell layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "cerebellar Purkinje cell layer structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021694
name: cerebellar Purkinje cell layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021695
name: cerebellar cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021696
name: cerebellar cortex morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021587 ! cerebellum morphogenesis
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021697
name: cerebellar cortex formation
namespace: biological_process
def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021698
name: cerebellar cortex structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "cerebellar cortex structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021699
name: cerebellar cortex maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021590 ! cerebellum maturation
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021700
name: developmental maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
subset: goslim_chembl
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0021701
name: cerebellar Golgi cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021702
name: cerebellar Purkinje cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation

[Term]
id: GO:0021703
name: locus ceruleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "locus caeruleus development" EXACT []
synonym: "locus coeruleus development" EXACT []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021704
name: locus ceruleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021703 ! locus ceruleus development

[Term]
id: GO:0021705
name: locus ceruleus formation
namespace: biological_process
def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021704 ! locus ceruleus morphogenesis

[Term]
id: GO:0021706
name: locus ceruleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021703 ! locus ceruleus development

[Term]
id: GO:0021707
name: cerebellar granule cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:1905962 ! glutamatergic neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021708
name: Lugaro cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021709
name: cerebellar basket cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021688 ! cerebellar molecular layer formation

[Term]
id: GO:0021710
name: cerebellar stellate cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021688 ! cerebellar molecular layer formation

[Term]
id: GO:0021711
name: cerebellar unipolar brush cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021712
name: candelabrum cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation

[Term]
id: GO:0021713
name: inferior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "inferior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021714
name: inferior olivary nucleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "inferior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis
relationship: part_of GO:0021713 ! inferior olivary nucleus development

[Term]
id: GO:0021715
name: inferior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "inferior olive biosynthesis" RELATED []
synonym: "inferior olive formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021580 ! medulla oblongata formation
relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis

[Term]
id: GO:0021716
name: inferior olivary nucleus structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "inferior olivary nucleus structural organisation" EXACT [GOC:mah]
synonym: "inferior olive structural organization" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021581 ! medulla oblongata structural organization
relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis

[Term]
id: GO:0021717
name: inferior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "inferior olive maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021582 ! medulla oblongata maturation
relationship: part_of GO:0021713 ! inferior olivary nucleus development

[Term]
id: GO:0021718
name: superior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021719
name: superior olivary nucleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021718 ! superior olivary nucleus development

[Term]
id: GO:0021720
name: superior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis

[Term]
id: GO:0021721
name: superior olivary nucleus structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olivary nucleus structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021585 ! pons structural organization
relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis

[Term]
id: GO:0021722
name: superior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021718 ! superior olivary nucleus development

[Term]
id: GO:0021723
name: medullary reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, https://www.ncbi.nlm.nih.gov/books/NBK556102/, Wikipedia:Rhombencephalon]
synonym: "rhombencephalic reticular formation development" BROAD []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021724
name: inferior raphe nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, PMID:19003874, ZFA:0000366]
synonym: "inferior central nucleus development" BROAD []
synonym: "posterior raphe nucleus development" BROAD []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021725
name: superior raphe nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, PMID:19003874, ZFA:0000440]
synonym: "anterior raphe nucleus development" BROAD []
synonym: "superior central nucleus development" BROAD []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021726
name: lateral reticular nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021727
name: intermediate reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
synonym: "intermediate reticular nucleus development" EXACT [http://www.brainspan.org]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021728
name: inferior reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021729
name: superior reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021730
name: trigeminal sensory nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
comment: Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0021731
name: trigeminal motor nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021732
name: midbrain-hindbrain boundary maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus maturation" RELATED []
synonym: "MHB maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021735
name: dentate nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021736
name: globose nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021737
name: emboliform nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021738
name: fastigial nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021739
name: mesencephalic trigeminal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021740
name: principal sensory nucleus of trigeminal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
comment: Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions.
synonym: "pontine nucleus development" BROAD [GOC:dph]
is_a: GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021741
name: spinal trigeminal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021742
name: abducens nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021743
name: hypoglossal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021744
name: dorsal motor nucleus of vagus nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021745
name: nucleus ambiguus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021746
name: solitary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021747
name: cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021748
name: dorsal cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021747 ! cochlear nucleus development

[Term]
id: GO:0021749
name: ventral cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021747 ! cochlear nucleus development

[Term]
id: GO:0021750
name: vestibular nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, PMID:16221589]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021751
name: salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021752
name: inferior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021751 ! salivary nucleus development

[Term]
id: GO:0021753
name: superior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021751 ! salivary nucleus development

[Term]
id: GO:0021754
name: facial nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021755
name: eurydendroid cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15892096]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021756
name: striatum development
namespace: biological_process
def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "neostriatum development" EXACT []
synonym: "striate nucleus development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0021757
name: caudate nucleus development
namespace: biological_process
def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021758
name: putamen development
namespace: biological_process
def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021759
name: globus pallidus development
namespace: biological_process
def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "pallidum development" EXACT [PMID:16271465]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021761
name: limbic system development
namespace: biological_process
def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048731 ! system development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021762
name: substantia nigra development
namespace: biological_process
def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:0021763
name: subthalamic nucleus development
namespace: biological_process
def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "corpus luysi development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021539 ! subthalamus development

[Term]
id: GO:0021764
name: amygdala development
namespace: biological_process
def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021765
name: cingulate gyrus development
namespace: biological_process
def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021766
name: hippocampus development
namespace: biological_process
def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]
synonym: "hippocampal formation development" EXACT [ABA:HPF]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021543 ! pallium development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021767
name: mammillary body development
namespace: biological_process
def: "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021768
name: nucleus accumbens development
namespace: biological_process
def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "accumbens nucleus development" EXACT [GOC:dgh]
synonym: "ventral striatum development" BROAD []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021769
name: orbitofrontal cortex development
namespace: biological_process
def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021770
name: parahippocampal gyrus development
namespace: biological_process
def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "hippocampal gyrus development" EXACT [GOC:dgh]
xref: Wikipedia:parahippocampal_gyrus
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021771
name: lateral geniculate nucleus development
namespace: biological_process
def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "LGN development" EXACT [GOC:dgh]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021794 ! thalamus development

[Term]
id: GO:0021772
name: olfactory bulb development
namespace: biological_process
def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021988 ! olfactory lobe development

[Term]
id: GO:0021773
name: striatal medium spiny neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741]
synonym: "striatal MSN differentiation" EXACT [PMID:25804741]
is_a: GO:0021879 ! forebrain neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021774
name: obsolete retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:sdb_2009, GOC:tb, PMID:11262869]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model.
synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT []
is_obsolete: true
consider: GO:0021521
consider: GO:0048384

[Term]
id: GO:0021775
name: smoothened signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "hedgehog signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT []
is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification

[Term]
id: GO:0021776
name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325]
synonym: "hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT []
is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification

[Term]
id: GO:0021777
name: obsolete BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT []
synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT []
is_obsolete: true

[Term]
id: GO:0021778
name: oligodendrocyte cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021780 ! glial cell fate specification
relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment

[Term]
id: GO:0021779
name: oligodendrocyte cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0021780
name: glial cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0021781 ! glial cell fate commitment

[Term]
id: GO:0021781
name: glial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0010001 ! glial cell differentiation

[Term]
id: GO:0021782
name: glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0010001 ! glial cell differentiation

[Term]
id: GO:0021783
name: preganglionic parasympathetic fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0048486 ! parasympathetic nervous system development

[Term]
id: GO:0021784
name: postganglionic parasympathetic fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048483 ! autonomic nervous system development
relationship: part_of GO:0007422 ! peripheral nervous system development
relationship: part_of GO:0048486 ! parasympathetic nervous system development

[Term]
id: GO:0021785
name: branchiomotor neuron axon guidance
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
synonym: "BMN axon guidance" EXACT [PMID:14699587]
synonym: "branchial motor axon guidance" EXACT [PMID:14699587]
synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587]
is_a: GO:0008045 ! motor neuron axon guidance

[Term]
id: GO:0021786
name: branchiomotor neuron axon guidance in neural tube
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
is_a: GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021787
name: chemorepulsion of branchiomotor neuron axon in neural tube
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
synonym: "negative chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah]
is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube
is_a: GO:0021793 ! chemorepulsion of branchiomotor axon

[Term]
id: GO:0021788
name: chemoattraction of branchiomotor neuron axon in neural tube
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
synonym: "positive chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah]
is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube
is_a: GO:0021792 ! chemoattraction of branchiomotor axon

[Term]
id: GO:0021789
name: branchiomotor neuron axon guidance in branchial arch mesenchyme
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
is_a: GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021790
name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
synonym: "negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah]
is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme
is_a: GO:0021793 ! chemorepulsion of branchiomotor axon

[Term]
id: GO:0021791
name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
synonym: "positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah]
is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme
is_a: GO:0021792 ! chemoattraction of branchiomotor axon

[Term]
id: GO:0021792
name: chemoattraction of branchiomotor axon
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
synonym: "positive chemotaxis of branchiomotor axon" EXACT [GOC:mah]
is_a: GO:0061642 ! chemoattraction of axon
relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021793
name: chemorepulsion of branchiomotor axon
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]
synonym: "negative chemotaxis of branchiomotor axon" EXACT [GOC:mah]
is_a: GO:0061643 ! chemorepulsion of axon
relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021794
name: thalamus development
namespace: biological_process
def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021795
name: cerebral cortex cell migration
namespace: biological_process
def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0021796
name: cerebral cortex regionalization
namespace: biological_process
def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "cerebral cortex arealization" EXACT []
synonym: "cerebral cortex pattern biosynthesis" EXACT []
synonym: "cerebral cortex pattern formation" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021978 ! telencephalon regionalization
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0021797
name: forebrain anterior/posterior pattern specification
namespace: biological_process
def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "forebrain anterior-posterior pattern specification" EXACT []
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021798
name: forebrain dorsal/ventral pattern formation
namespace: biological_process
def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "forebrain dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "forebrain dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021799
name: cerebral cortex radially oriented cell migration
namespace: biological_process
def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021795 ! cerebral cortex cell migration

[Term]
id: GO:0021800
name: cerebral cortex tangential migration
namespace: biological_process
def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021795 ! cerebral cortex cell migration

[Term]
id: GO:0021801
name: cerebral cortex radial glia-guided migration
namespace: biological_process
def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cerebral cortex radial glia guided migration" EXACT []
synonym: "cerebral cortex radial glia-dependent cell migration" EXACT []
synonym: "glial-guided locomotion" RELATED [PMID:12626695]
is_a: GO:0021799 ! cerebral cortex radially oriented cell migration
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0021802
name: somal translocation
namespace: biological_process
def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695]
is_a: GO:0021799 ! cerebral cortex radially oriented cell migration

[Term]
id: GO:0021803
name: extension of leading cell process to pial surface
namespace: biological_process
def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021804
name: negative regulation of cell adhesion in ventricular zone
namespace: biological_process
def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "down regulation of cell adhesion in ventricular zone" EXACT []
synonym: "down-regulation of cell adhesion in ventricular zone" EXACT []
synonym: "downregulation of cell adhesion in ventricular zone" EXACT []
synonym: "inhibition of cell adhesion in ventricular zone" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021805
name: cell movement involved in somal translocation
namespace: biological_process
def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cell motility involved in somal translocation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021806
name: initiation of movement involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021807
name: motogenic signaling initiating cell movement in cerebral cortex
namespace: biological_process
def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023052 ! signaling
relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021808
name: obsolete cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
namespace: biological_process
def: "OBSOLETE. The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT []
is_obsolete: true
consider: GO:0019722

[Term]
id: GO:0021809
name: obsolete neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "OBSOLETE. Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT []
is_obsolete: true

[Term]
id: GO:0021810
name: obsolete neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "OBSOLETE. Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT []
is_obsolete: true

[Term]
id: GO:0021811
name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio]
synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT []
is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex

[Term]
id: GO:0021812
name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0021801 ! cerebral cortex radial glia-guided migration

[Term]
id: GO:0021813
name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021814
name: cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph]
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0021801 ! cerebral cortex radial glia-guided migration

[Term]
id: GO:0021815
name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021816
name: extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
is_a: GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0021817
name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695]
synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030473 ! nuclear migration along microtubule
relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021818
name: obsolete modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration
namespace: biological_process
def: "OBSOLETE. The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
comment: The reason for obsoletion is that this term represents a GO-CAM model
synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_obsolete: true

[Term]
id: GO:0021819
name: layer formation in cerebral cortex
namespace: biological_process
def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cerebral cortex lamination" RELATED [PMID:12626695]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021801 ! cerebral cortex radial glia-guided migration

[Term]
id: GO:0021820
name: extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration" EXACT [GOC:mah]
synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0021819 ! layer formation in cerebral cortex

[Term]
id: GO:0021821
name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination
namespace: biological_process
def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
relationship: part_of GO:0021819 ! layer formation in cerebral cortex

[Term]
id: GO:0021822
name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695]
synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW []
synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb]
is_a: GO:1903976 ! negative regulation of glial cell migration
relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration
relationship: part_of GO:0021819 ! layer formation in cerebral cortex

[Term]
id: GO:0021823
name: cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def: "The process in which neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "chain migration" RELATED [PMID:12626695]
is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration

[Term]
id: GO:0021824
name: cerebral cortex tangential migration using cell-axon interactions
namespace: biological_process
def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration

[Term]
id: GO:0021825
name: substrate-dependent cerebral cortex tangential migration
namespace: biological_process
def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0006929 ! substrate-dependent cell migration
is_a: GO:0021800 ! cerebral cortex tangential migration

[Term]
id: GO:0021826
name: substrate-independent telencephalic tangential migration
namespace: biological_process
def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0022029 ! telencephalon cell migration

[Term]
id: GO:0021827
name: postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions
is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb
relationship: part_of GO:0021891 ! olfactory bulb interneuron development

[Term]
id: GO:0021828
name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus
namespace: biological_process
alt_id: GO:0021857
def: "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "gonadotropin-releasing hormone neuronal migration to the hypothalamus" EXACT [GOC:dph]
is_a: GO:0001764 ! neuron migration
is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions
relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development

[Term]
id: GO:0021829
name: oligodendrocyte cell migration from the subpallium to the cortex
namespace: biological_process
def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021826 ! substrate-independent telencephalic tangential migration
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0021830
name: interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021831
name: embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration
is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb
relationship: part_of GO:0021891 ! olfactory bulb interneuron development

[Term]
id: GO:0021832
name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions

[Term]
id: GO:0021833
name: cell-matrix adhesion involved in tangential migration using cell-cell interactions
namespace: biological_process
def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695]
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions

[Term]
id: GO:0021834
name: chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def: "The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "negative chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration

[Term]
id: GO:0021835
name: chemoattraction involved in embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def: "The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "positive chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration

[Term]
id: GO:0021836
name: chemorepulsion involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "negative chemotaxis involved in postnatal olfactory bulb interneuron migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration

[Term]
id: GO:0021837
name: motogenic signaling involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023052 ! signaling
relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration

[Term]
id: GO:0021838
name: motogenic signaling involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023052 ! signaling
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021839
name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021840
name: directional guidance of interneurons involved in migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0030334 ! regulation of cell migration
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021841
name: chemoattraction involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "positive chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex

[Term]
id: GO:0021842
name: chemorepulsion involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "negative chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex

[Term]
id: GO:0021843
name: substrate-independent telencephalic tangential interneuron migration
namespace: biological_process
def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021826 ! substrate-independent telencephalic tangential migration

[Term]
id: GO:0021844
name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration
namespace: biological_process
def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0042330 ! taxis
relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021845
name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration
namespace: biological_process
def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0030334 ! regulation of cell migration
relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021846
name: cell proliferation in forebrain
namespace: biological_process
def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021847
name: ventricular zone neuroblast division
namespace: biological_process
def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "neuroblast division in ventricular zone" EXACT []
is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division
is_a: GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021848
name: neuroblast division in subpallium
namespace: biological_process
def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447]
is_a: GO:0055057 ! neuroblast division
relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0021849
name: neuroblast division in subventricular zone
namespace: biological_process
def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0055057 ! neuroblast division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021850
name: subpallium glioblast cell division
namespace: biological_process
def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "glioblast cell division in subpallium" EXACT []
synonym: "glioblast division in ventral telencephalon" EXACT [PMID:16226447]
is_a: GO:0048860 ! glioblast division
relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0021851
name: neuroblast division in dorsal lateral ganglionic eminence
namespace: biological_process
def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021848 ! neuroblast division in subpallium

[Term]
id: GO:0021852
name: pyramidal neuron migration to cerebral cortex
namespace: biological_process
def: "The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695, PMID:22192824]
synonym: "projection neuron migration" RELATED [PMID:12626695]
synonym: "pyramidal neuron migration" BROAD []
is_a: GO:0021801 ! cerebral cortex radial glia-guided migration
is_a: GO:0140650 ! radial glia-guided pyramidal neuron migration
relationship: part_of GO:0021860 ! pyramidal neuron development

[Term]
id: GO:0021853
name: cerebral cortex GABAergic interneuron migration
namespace: biological_process
def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex
is_a: GO:1904936 ! interneuron migration
relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development

[Term]
id: GO:0021854
name: hypothalamus development
namespace: biological_process
def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021855
name: hypothalamus cell migration
namespace: biological_process
def: "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0021854 ! hypothalamus development

[Term]
id: GO:0021856
name: hypothalamic tangential migration using cell-axon interactions
namespace: biological_process
def: "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021855 ! hypothalamus cell migration

[Term]
id: GO:0021858
name: GABAergic neuron differentiation in basal ganglia
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0097154 ! GABAergic neuron differentiation

[Term]
id: GO:0021859
name: pyramidal neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "projection neuron differentiation" BROAD [PMID:16226447]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0021860
name: pyramidal neuron development
namespace: biological_process
def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "projection neuron development" BROAD [PMID:16226447]
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021859 ! pyramidal neuron differentiation

[Term]
id: GO:0021861
name: forebrain radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "radial glial cell differentiation in forebrain" EXACT []
is_a: GO:0060019 ! radial glial cell differentiation
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021862
name: early neuron differentiation in forebrain
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021863
name: forebrain neuroblast differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447]
is_a: GO:0014016 ! neuroblast differentiation
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021864
name: obsolete radial glial cell division in forebrain
namespace: biological_process
def: "OBSOLETE. The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0021865
name: obsolete symmetric radial glial cell division in forebrain
namespace: biological_process
def: "OBSOLETE. The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0021866
name: obsolete asymmetric radial glial cell division in forebrain
namespace: biological_process
def: "OBSOLETE. The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0021867
name: obsolete neuron-producing asymmetric radial glial cell division in forebrain
namespace: biological_process
def: "OBSOLETE. The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0021868
name: obsolete ventricular zone cell-producing asymmetric radial glial cell division in forebrain
namespace: biological_process
def: "OBSOLETE. The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0021869
name: forebrain ventricular zone progenitor cell division
namespace: biological_process
def: "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021870
name: Cajal-Retzius cell differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021895 ! cerebral cortex neuron differentiation

[Term]
id: GO:0021871
name: forebrain regionalization
namespace: biological_process
def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:16226447]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021872
name: forebrain generation of neurons
namespace: biological_process
def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "generation of neurons in forebrain" EXACT []
is_a: GO:0048699 ! generation of neurons
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021873
name: forebrain neuroblast division
namespace: biological_process
def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0055057 ! neuroblast division
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021874
name: Wnt signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "Wnt receptor signaling pathway involved in forebrain neuroblast division" EXACT []
synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT []
synonym: "Wnt-activated signaling pathway involved in forebrain neuroblast division" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021875
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021876
name: Notch signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT []
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021877
name: forebrain neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021878
name: forebrain astrocyte fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0060018 ! astrocyte fate commitment
relationship: part_of GO:0021896 ! forebrain astrocyte differentiation

[Term]
id: GO:0021879
name: forebrain neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021880
name: obsolete Notch signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_obsolete: true
consider: GO:0007219

[Term]
id: GO:0021881
name: obsolete Wnt-activated signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_obsolete: true
consider: GO:0016055
consider: GO:0021877

[Term]
id: GO:0021882
name: obsolete regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0021877

[Term]
id: GO:0021883
name: obsolete cell cycle arrest of committed forebrain neuronal progenitor cell
namespace: biological_process
def: "OBSOLETE. The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:16226447]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0021884
name: forebrain neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021885
name: forebrain cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021886
name: hypothalamus gonadotrophin-releasing hormone neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "hypothalamus gonadotropin-releasing hormone neuron differentiation" EXACT [GOC:dph]
is_a: GO:0021979 ! hypothalamus cell differentiation

[Term]
id: GO:0021887
name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "hypothalamus gonadotropin-releasing hormone neuron fate commitment" RELATED [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation

[Term]
id: GO:0021888
name: hypothalamus gonadotrophin-releasing hormone neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "hypothalamus gonadotropin-releasing hormone neuron development" RELATED [GOC:dph]
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation

[Term]
id: GO:0021889
name: olfactory bulb interneuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0021890
name: olfactory bulb interneuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation

[Term]
id: GO:0021891
name: olfactory bulb interneuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation

[Term]
id: GO:0021892
name: cerebral cortex GABAergic interneuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021895 ! cerebral cortex neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation

[Term]
id: GO:0021893
name: cerebral cortex GABAergic interneuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation

[Term]
id: GO:0021894
name: cerebral cortex GABAergic interneuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation

[Term]
id: GO:0021895
name: cerebral cortex neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021896
name: forebrain astrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0048708 ! astrocyte differentiation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021897
name: forebrain astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0014002 ! astrocyte development
relationship: part_of GO:0021896 ! forebrain astrocyte differentiation

[Term]
id: GO:0021898
name: commitment of multipotent stem cells to neuronal lineage in forebrain
namespace: biological_process
def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021877 ! forebrain neuron fate commitment

[Term]
id: GO:0021899
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0021900
name: ventricular zone cell fate commitment
namespace: biological_process
def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain
relationship: part_of GO:0021863 ! forebrain neuroblast differentiation

[Term]
id: GO:0021901
name: early neuron fate commitment in forebrain
namespace: biological_process
def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain
relationship: part_of GO:0021862 ! early neuron differentiation in forebrain

[Term]
id: GO:0021902
name: commitment of neuronal cell to specific neuron type in forebrain
namespace: biological_process
def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0021877 ! forebrain neuron fate commitment

[Term]
id: GO:0021903
name: rostrocaudal neural tube patterning
namespace: biological_process
def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0021532 ! neural tube patterning

[Term]
id: GO:0021904
name: dorsal/ventral neural tube patterning
namespace: biological_process
def: "The process in which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "dorsal-ventral neural tube patterning" EXACT [GOC:dph]
synonym: "dorsoventral neural tube patterning" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021532 ! neural tube patterning

[Term]
id: GO:0021905
name: forebrain-midbrain boundary formation
namespace: biological_process
def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0021906
name: hindbrain-spinal cord boundary formation
namespace: biological_process
def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0021907
name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021908
name: obsolete retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model.
synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT []
is_obsolete: true
consider: GO:0021512
consider: GO:0048384

[Term]
id: GO:0021909
name: obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0021512

[Term]
id: GO:0021910
name: smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:11262869]
synonym: "hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT []
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning

[Term]
id: GO:0021911
name: retinoic acid metabolic process in spinal cord anterior-posterior patterning
namespace: biological_process
def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021912
name: obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0021520

[Term]
id: GO:0021913
name: obsolete regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0021521

[Term]
id: GO:0021914
name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:11262869]
synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW []
synonym: "negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT []
is_a: GO:0045879 ! negative regulation of smoothened signaling pathway
relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning

[Term]
id: GO:0021915
name: neural tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0021916
name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors
namespace: biological_process
def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT []
is_a: GO:0031129 ! inductive cell-cell signaling
relationship: part_of GO:0021917 ! somatic motor neuron fate commitment

[Term]
id: GO:0021917
name: somatic motor neuron fate commitment
namespace: biological_process
def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021918
name: obsolete regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0021917

[Term]
id: GO:0021919
name: obsolete BMP signaling pathway involved in spinal cord dorsal/ventral patterning
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signaling pathway in spinal cord dorsoventral patterning" EXACT [GOC:mah]
synonym: "BMP signaling pathway involved in spinal cord dorsal-ventral patterning" EXACT [GOC:mah]
synonym: "BMP signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT []
synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT []
is_obsolete: true
consider: GO:0021513
consider: GO:0030509

[Term]
id: GO:0021920
name: obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0021519

[Term]
id: GO:0021921
name: regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
relationship: part_of GO:0021516 ! dorsal spinal cord development
relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord

[Term]
id: GO:0021922
name: obsolete Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT []
synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT []
synonym: "Wnt-activated signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0016055
consider: GO:0042127

[Term]
id: GO:0021923
name: cell proliferation in hindbrain ventricular zone
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981, PMID:15157725]
is_a: GO:0021534 ! cell proliferation in hindbrain

[Term]
id: GO:0021924
name: cell proliferation in external granule layer
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021534 ! cell proliferation in hindbrain

[Term]
id: GO:0021925
name: cerebellar Purkinje cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021926
name: Golgi cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021927
name: deep nuclear neuron precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021928
name: basket cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021929
name: stellate cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021930
name: cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021924 ! cell proliferation in external granule layer

[Term]
id: GO:0021931
name: rostral hindbrain neuronal precursor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021924 ! cell proliferation in external granule layer

[Term]
id: GO:0021932
name: hindbrain radial glia guided cell migration
namespace: biological_process
def: "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021933
name: radial glia guided migration of cerebellar granule cell
namespace: biological_process
def: "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021934
name: hindbrain tangential cell migration
namespace: biological_process
def: "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725]
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021935
name: cerebellar granule cell precursor tangential migration
namespace: biological_process
def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021934 ! hindbrain tangential cell migration

[Term]
id: GO:0021936
name: regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
relationship: regulates GO:0021930 ! cerebellar granule cell precursor proliferation

[Term]
id: GO:0021937
name: cerebellar Purkinje cell-granule cell precursor cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from Purkinje cells to granule cell precursors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725, PMID:32554107]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0021938
name: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:15157725]
synonym: "hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT []
is_a: GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0021939
name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation
namespace: biological_process
def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT []
is_a: GO:0035426 ! extracellular matrix-cell signaling
relationship: part_of GO:0021941 ! negative regulation of cerebellar granule cell precursor proliferation

[Term]
id: GO:0021940
name: positive regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
synonym: "activation of granule cell precursor proliferation" NARROW []
synonym: "stimulation of granule cell precursor proliferation" NARROW []
synonym: "up regulation of granule cell precursor proliferation" EXACT []
synonym: "up-regulation of granule cell precursor proliferation" EXACT []
synonym: "upregulation of granule cell precursor proliferation" EXACT []
is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
relationship: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation

[Term]
id: GO:0021941
name: negative regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
synonym: "down regulation of granule cell precursor proliferation" EXACT []
synonym: "down-regulation of granule cell precursor proliferation" EXACT []
synonym: "downregulation of granule cell precursor proliferation" EXACT []
synonym: "inhibition of granule cell precursor proliferation" NARROW []
is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
relationship: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation

[Term]
id: GO:0021942
name: radial glia guided migration of Purkinje cell
namespace: biological_process
def: "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021943
name: formation of radial glial scaffolds
namespace: biological_process
def: "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725]
synonym: "Bergmann fiber formation" RELATED [PMID:15157725]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021944
name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
namespace: biological_process
def: "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021945
name: obsolete positive regulation of cerebellar granule cell migration by calcium
namespace: biological_process
def: "OBSOLETE. The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:15157725]
comment: This term was obsoleted because it is a pre-composed term that should be represented as a GO-CAM model.
synonym: "calcium-mediated activation of granule cell migration" NARROW []
synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb]
synonym: "calcium-mediated stimulation of granule cell migration" NARROW []
synonym: "calcium-mediated up regulation of granule cell migration" EXACT []
synonym: "calcium-mediated up-regulation of granule cell migration" EXACT []
synonym: "calcium-mediated upregulation of granule cell migration" EXACT []
is_obsolete: true

[Term]
id: GO:0021946
name: deep nuclear neuron cell migration
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021947
name: outward migration of deep nuclear neurons
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0001764 ! neuron migration
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0021946 ! deep nuclear neuron cell migration

[Term]
id: GO:0021948
name: inward migration of deep nuclear neurons
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0001764 ! neuron migration
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0021946 ! deep nuclear neuron cell migration

[Term]
id: GO:0021949
name: brainstem precerebellar neuron precursor migration
namespace: biological_process
def: "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021934 ! hindbrain tangential cell migration

[Term]
id: GO:0021950
name: chemorepulsion involved in precerebellar neuron migration
namespace: biological_process
def: "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
synonym: "negative chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration

[Term]
id: GO:0021951
name: chemoattraction involved in precerebellar neuron migration
namespace: biological_process
def: "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
synonym: "positive chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration

[Term]
id: GO:0021952
name: central nervous system projection neuron axonogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "central nervous system axon tract development" NARROW [GOC:dph]
is_a: GO:0021955 ! central nervous system neuron axonogenesis

[Term]
id: GO:0021953
name: central nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021954
name: central nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0021953 ! central nervous system neuron differentiation

[Term]
id: GO:0021955
name: central nervous system neuron axonogenesis
namespace: biological_process
def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0021954 ! central nervous system neuron development

[Term]
id: GO:0021956
name: central nervous system interneuron axonogenesis
namespace: biological_process
def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021955 ! central nervous system neuron axonogenesis

[Term]
id: GO:0021957
name: corticospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731]
synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021958
name: gracilis tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698]
synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021959
name: cuneatus tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698]
synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021960
name: anterior commissure morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021961
name: posterior commissure morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021962
name: vestibulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021963
name: spinothalamic tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT []
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021964
name: rubrospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021965
name: spinal cord ventral commissure morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021966
name: corticospinal neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal neuron axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021957 ! corticospinal tract morphogenesis

[Term]
id: GO:0021967
name: corticospinal neuron axon guidance through the cerebral cortex
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal neuron axon pathfinding through the cerebral cortex" NARROW [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021968
name: corticospinal neuron axon guidance through the internal capsule
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal neuron axon pathfinding through the internal capsule" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021969
name: corticospinal neuron axon guidance through the cerebral peduncle
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal neuron axon pathfinding through the cerebral peduncle" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021970
name: corticospinal neuron axon guidance through the basilar pons
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal neuron axon pathfinding through the basilar pons" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021971
name: corticospinal neuron axon guidance through the medullary pyramid
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal neuron axon pathfinding through the medullary pyramid" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021972
name: corticospinal neuron axon guidance through spinal cord
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
synonym: "corticospinal neuron axon pathfinding through spinal cord" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021973
name: corticospinal neuron axon decussation
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]
is_a: GO:0016199 ! axon midline choice point recognition
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021974
name: trigeminothalamic tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021975
name: pons reticulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021976
name: medulla reticulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021977
name: tectospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021978
name: telencephalon regionalization
namespace: biological_process
def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021537 ! telencephalon development
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021979
name: hypothalamus cell differentiation
namespace: biological_process
def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021854 ! hypothalamus development

[Term]
id: GO:0021980
name: subpallium cell migration
namespace: biological_process
def: "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0021981
name: subpallium radially oriented migration
namespace: biological_process
def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021980 ! subpallium cell migration

[Term]
id: GO:0021982
name: pineal gland development
namespace: biological_process
def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "epiphysis development" EXACT [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0021983
name: pituitary gland development
namespace: biological_process
def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "hypophysis development" RELATED [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0021984
name: adenohypophysis development
namespace: biological_process
def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis development" EXACT []
synonym: "anterior pituitary development" EXACT []
synonym: "anterior pituitary gland development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021983 ! pituitary gland development

[Term]
id: GO:0021985
name: neurohypophysis development
namespace: biological_process
def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis development" EXACT []
synonym: "posterior pituitary development" EXACT []
synonym: "posterior pituitary gland development" EXACT []
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021983 ! pituitary gland development

[Term]
id: GO:0021986
name: habenula development
namespace: biological_process
def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:9780721601465]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021538 ! epithalamus development

[Term]
id: GO:0021987
name: cerebral cortex development
namespace: biological_process
def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "corticogenesis" NARROW [GOC:bf, PMID:25904839]
synonym: "neocortex development" RELATED [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021543 ! pallium development

[Term]
id: GO:0021988
name: olfactory lobe development
namespace: biological_process
def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021989
name: olfactory cortex development
namespace: biological_process
def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021988 ! olfactory lobe development

[Term]
id: GO:0021990
name: neural plate formation
namespace: biological_process
def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0021991
name: neural plate thickening
namespace: biological_process
def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0021992
name: cell proliferation involved in neural plate elongation
namespace: biological_process
def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0014022 ! neural plate elongation

[Term]
id: GO:0021993
name: initiation of neural tube closure
namespace: biological_process
def: "The process in which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021994
name: progression of neural tube closure
namespace: biological_process
def: "The process in which the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021995
name: neuropore closure
namespace: biological_process
def: "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021996
name: lamina terminalis formation
namespace: biological_process
def: "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021506 ! anterior neuropore closure

[Term]
id: GO:0021997
name: neural plate axis specification
namespace: biological_process
def: "The pattern specification process in which the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neural plate axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
relationship: part_of GO:0001840 ! neural plate development
relationship: part_of GO:0060896 ! neural plate pattern specification

[Term]
id: GO:0021998
name: neural plate mediolateral regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neural plate mediolateral pattern formation" RELATED [GOC:dph]
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0021999
name: neural plate anterior/posterior regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0022000
name: forebrain induction by the anterior neural ridge
namespace: biological_process
def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0031128 ! developmental induction
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0022001
name: negative regulation of anterior neural cell fate commitment of the neural plate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]
synonym: "caudalization of neural plate" EXACT []
synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "posteriorization" BROAD []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0051961 ! negative regulation of nervous system development
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0022002
name: obsolete negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT []
is_obsolete: true
consider: GO:0016055

[Term]
id: GO:0022003
name: negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]
synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT []
is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate
is_a: GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

[Term]
id: GO:0022004
name: midbrain-hindbrain boundary maturation during brain development
namespace: biological_process
def: "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation

[Term]
id: GO:0022005
name: midbrain-hindbrain boundary maturation during neural plate development
namespace: biological_process
def: "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "midbrain-hindbrain boundary maturation involved in neural plate development" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation

[Term]
id: GO:0022006
name: zona limitans intrathalamica formation
namespace: biological_process
def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11425897, PMID:16452095]
synonym: "zli biosynthesis" EXACT []
synonym: "zli formation" EXACT []
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0022007
name: convergent extension involved in neural plate elongation
namespace: biological_process
def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060029 ! convergent extension involved in organogenesis
relationship: part_of GO:0014022 ! neural plate elongation

[Term]
id: GO:0022008
name: neurogenesis
namespace: biological_process
def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
synonym: "nervous system cell generation" EXACT systematic_synonym []
synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph]
xref: Wikipedia:Neurogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0022009
name: central nervous system vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001570 ! vasculogenesis

[Term]
id: GO:0022010
name: central nervous system myelination
namespace: biological_process
def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "myelination in central nervous system" EXACT []
is_a: GO:0032291 ! axon ensheathment in central nervous system
is_a: GO:0042552 ! myelination
relationship: part_of GO:0014003 ! oligodendrocyte development

[Term]
id: GO:0022011
name: myelination in peripheral nervous system
namespace: biological_process
def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "peripheral nervous system myelination" EXACT []
is_a: GO:0032292 ! peripheral nervous system axon ensheathment
is_a: GO:0042552 ! myelination
relationship: part_of GO:0014044 ! Schwann cell development

[Term]
id: GO:0022012
name: subpallium cell proliferation in forebrain
namespace: biological_process
def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021846 ! cell proliferation in forebrain
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0022013
name: pallium cell proliferation in forebrain
namespace: biological_process
def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021846 ! cell proliferation in forebrain
relationship: part_of GO:0021543 ! pallium development

[Term]
id: GO:0022014
name: obsolete radial glial cell division in subpallium
namespace: biological_process
def: "OBSOLETE. The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0022015
name: radial glial cell division in pallium
namespace: biological_process
def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain

[Term]
id: GO:0022016
name: pallium glioblast division
namespace: biological_process
def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "glioblast cell division in pallium" EXACT []
is_a: GO:0048860 ! glioblast division
relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain

[Term]
id: GO:0022017
name: neuroblast division in pallium
namespace: biological_process
def: "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain

[Term]
id: GO:0022018
name: lateral ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022019
name: dorsal lateral ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022012 ! subpallium cell proliferation in forebrain
relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation

[Term]
id: GO:0022020
name: medial ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022021
name: caudal ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022022
name: septal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "septum cell proliferation" EXACT []
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022023
name: radial glial cell fate commitment in forebrain
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain
relationship: part_of GO:0021861 ! forebrain radial glial cell differentiation

[Term]
id: GO:0022024
name: obsolete BMP signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_obsolete: true
consider: GO:0021877
consider: GO:0030509

[Term]
id: GO:0022025
name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by the binding of leukemia inhibitory factor to its receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:signaling]
synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0022026
name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0022027
name: interkinetic nuclear migration
namespace: biological_process
def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0022028
name: tangential migration from the subventricular zone to the olfactory bulb
namespace: biological_process
def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "rostral migratory stream migration" EXACT []
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0022029
name: telencephalon cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021885 ! forebrain cell migration
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0022030
name: telencephalon glial cell migration
namespace: biological_process
def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0008347 ! glial cell migration
is_a: GO:0022029 ! telencephalon cell migration

[Term]
id: GO:0022031
name: telencephalon astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022030 ! telencephalon glial cell migration
is_a: GO:0043615 ! astrocyte cell migration

[Term]
id: GO:0022032
name: telencephalon oligodendrocyte cell migration
namespace: biological_process
def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0022033
name: telencephalon microglial cell migration
namespace: biological_process
def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0022034
name: rhombomere cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022035
name: rhombomere cell migration
namespace: biological_process
def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700]
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022036
name: rhombomere cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022037
name: metencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0022038
name: corpus callosum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0022400
name: regulation of opsin-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of opsin-mediated signaling." [GOC:mah]
synonym: "regulation of rhodopsin mediated signaling pathway" EXACT []
synonym: "regulation of rhodopsin mediated signalling" EXACT []
synonym: "regulation of rhodopsin-mediated signaling pathway" NARROW []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0016056 ! G protein-coupled opsin signaling pathway

[Term]
id: GO:0022401
name: negative adaptation of signaling pathway
namespace: biological_process
def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete]
synonym: "negative adaptation of signal transduction pathway" EXACT []
synonym: "negative adaptation of signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0023058 ! adaptation of signaling pathway

[Term]
id: GO:0022402
name: cell cycle process
namespace: biological_process
def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0022403
name: cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0022404
name: molting cycle process
namespace: biological_process
def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0042303 ! molting cycle

[Term]
id: GO:0022405
name: hair cycle process
namespace: biological_process
def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0042633 ! hair cycle

[Term]
id: GO:0022406
name: membrane docking
namespace: biological_process
def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0022407
name: regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0022408
name: negative regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "down regulation of cell-cell adhesion" EXACT []
synonym: "down-regulation of cell-cell adhesion" EXACT []
synonym: "downregulation of cell-cell adhesion" EXACT []
synonym: "inhibition of cell-cell adhesion" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: negatively_regulates GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0022409
name: positive regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "activation of cell-cell adhesion" NARROW []
synonym: "stimulation of cell-cell adhesion" NARROW []
synonym: "up regulation of cell-cell adhesion" EXACT []
synonym: "up-regulation of cell-cell adhesion" EXACT []
synonym: "upregulation of cell-cell adhesion" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
relationship: positively_regulates GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0022410
name: circadian sleep/wake cycle process
namespace: biological_process
def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete]
is_a: GO:0048512 ! circadian behavior
relationship: part_of GO:0042745 ! circadian sleep/wake cycle

[Term]
id: GO:0022411
name: cellular component disassembly
namespace: biological_process
alt_id: GO:0071845
def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cell structure disassembly" EXACT []
synonym: "cellular component disassembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0022412
name: cellular process involved in reproduction in multicellular organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete]
synonym: "reproductive cellular process in multicellular organism" EXACT []
is_a: GO:0009987 ! cellular process
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0022413
name: reproductive process in single-celled organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete]
subset: gocheck_do_not_annotate
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0022414
name: reproductive process
namespace: biological_process
alt_id: GO:0044702
def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "single organism reproductive process" RELATED []
xref: Wikipedia:Reproduction
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0022416
name: chaeta development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
synonym: "bristle development" NARROW [GOC:bf, GOC:dos]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0022417
name: protein maturation by protein folding
namespace: biological_process
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete]
is_a: GO:0006457 ! protein folding
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0022600
name: digestive system process
namespace: biological_process
def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]
subset: goslim_generic
is_a: GO:0003008 ! system process
relationship: part_of GO:0007586 ! digestion

[Term]
id: GO:0022601
name: menstrual cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0022602
name: ovulation cycle process
namespace: biological_process
def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete]
synonym: "estrous cycle process" RELATED []
synonym: "menstrual cycle process" RELATED []
is_a: GO:0022414 ! reproductive process
is_a: GO:0048511 ! rhythmic process
relationship: part_of GO:0042698 ! ovulation cycle

[Term]
id: GO:0022603
name: regulation of anatomical structure morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]
synonym: "regulation of morphogenesis" EXACT []
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0022604
name: regulation of cell morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete]
synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0000902 ! cell morphogenesis

[Term]
id: GO:0022605
name: mammalian oogenesis stage
namespace: biological_process
def: "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu]
synonym: "mammalian oogenesis process" EXACT []
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0022606
name: establishment of proximal/distal cell polarity
namespace: biological_process
def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete]
is_a: GO:0061162 ! establishment of monopolar cell polarity

[Term]
id: GO:0022607
name: cellular component assembly
namespace: biological_process
alt_id: GO:0071844
def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_pir
synonym: "cell structure assembly" EXACT []
synonym: "cellular component assembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022608
name: multicellular organism adhesion
namespace: biological_process
def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0022609
name: multicellular organism adhesion to substrate
namespace: biological_process
def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete]
is_a: GO:0022608 ! multicellular organism adhesion

[Term]
id: GO:0022610
name: obsolete biological adhesion
namespace: biological_process
def: "OBSOLETE. The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete]
comment: This term was obsoleted because it represents an unnecessary grouping class by mixing cellular and multi-cellular organism level processes.
is_obsolete: true

[Term]
id: GO:0022611
name: dormancy process
namespace: biological_process
def: "A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated." [GOC:isa_complete, GOC:PO_curators, PO_REF:00009]
comment: In plants and animals, dormancy may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. In plants, dormancy may involve the formation of dormant buds, and may be preceded by the senescence of plant parts such as leaves in woody plants or most of the shoot system in herbaceous perennials. The exit from dormancy in vascular plants is marked by resumed growth of buds and/or growth of vascular cambium.
synonym: "multicellular organism dormancy process" NARROW []
synonym: "spore dormancy process" NARROW [GOC:PO_curators]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0022612
name: gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0048732 ! gland development

[Term]
id: GO:0022613
name: ribonucleoprotein complex biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]
synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah]
synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022614
name: membrane to membrane docking
namespace: biological_process
def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete]
synonym: "membrane-membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking

[Term]
id: GO:0022615
name: protein to membrane docking
namespace: biological_process
def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]
synonym: "protein-membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking

[Term]
id: GO:0022616
name: DNA strand elongation
namespace: biological_process
def: "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0022617
name: extracellular matrix disassembly
namespace: biological_process
def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0022618
name: protein-RNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]
subset: goslim_chembl
synonym: "ribonucleoprotein complex assembly" EXACT []
synonym: "RNA-protein complex assembly" EXACT []
synonym: "RNP complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0071826 ! protein-RNA complex organization
relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0022619
name: generative cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0022620
name: microgametophyte vegetative cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a microgametophyte. The microgametophyte vegetative cell gives rise to the pollen tube." [GOC:isa_complete]
synonym: "tube cell differentiation" RELATED []
synonym: "vegetative cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0022622
name: root system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete]
is_a: GO:0048731 ! system development

[Term]
id: GO:0022623
name: proteasome-activating nucleotidase complex
namespace: cellular_component
def: "A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:bf, GOC:mtg_sensu, PMID:19363223, PMID:19481528]
synonym: "PAN" EXACT [PMID:19363223, PMID:19481528]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0022624
name: proteasome accessory complex
namespace: cellular_component
def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000502 ! proteasome complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0022625
name: cytosolic large ribosomal subunit
namespace: cellular_component
alt_id: GO:0005842
alt_id: GO:0009282
alt_id: GO:0030498
alt_id: GO:0030872
def: "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
synonym: "50S ribosomal subunit" NARROW []
synonym: "60S ribosomal subunit" NARROW []
synonym: "eukaryotic ribosomal LSU" NARROW []
synonym: "prokaryotic large ribosomal subunit" NARROW []
is_a: GO:0015934 ! large ribosomal subunit
relationship: part_of GO:0022626 ! cytosolic ribosome

[Term]
id: GO:0022626
name: cytosolic ribosome
namespace: cellular_component
alt_id: GO:0005830
alt_id: GO:0009281
alt_id: GO:0030871
def: "A ribosome located in the cytosol." [GOC:mtg_sensu]
synonym: "70S ribosome" NARROW []
synonym: "80S ribosome" NARROW []
is_a: GO:0005840 ! ribosome
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0022627
name: cytosolic small ribosomal subunit
namespace: cellular_component
alt_id: GO:0005843
alt_id: GO:0009283
alt_id: GO:0030499
alt_id: GO:0030873
def: "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
synonym: "30S ribosomal subunit" NARROW []
synonym: "40S ribosomal subunit" NARROW []
synonym: "eukaryotic ribosomal SSU" NARROW []
synonym: "prokaryotic small ribosomal subunit" NARROW []
is_a: GO:0015935 ! small ribosomal subunit
relationship: part_of GO:0022626 ! cytosolic ribosome

[Term]
id: GO:0022628
name: chloroplast large ribosomal subunit
namespace: cellular_component
def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu]
synonym: "chloroplast ribosomal large subunit complex" EXACT []
synonym: "chloroplast ribosomal LSU complex" EXACT []
is_a: GO:0000311 ! plastid large ribosomal subunit
relationship: part_of GO:0043253 ! chloroplast ribosome

[Term]
id: GO:0022629
name: chloroplast small ribosomal subunit
namespace: cellular_component
def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu]
synonym: "chloroplast ribosomal small subunit complex" EXACT []
synonym: "chloroplast ribosomal SSU complex" EXACT []
is_a: GO:0000312 ! plastid small ribosomal subunit
relationship: part_of GO:0043253 ! chloroplast ribosome

[Term]
id: GO:0022803
name: passive transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0022814
def: "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
synonym: "facilitated diffusion" RELATED []
synonym: "porters" BROAD []
synonym: "uniporter activity z" NARROW []
xref: Wikipedia:Facilitated_diffusion
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022804
name: active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
synonym: "active carrier activity" EXACT []
synonym: "carrier activity" EXACT []
synonym: "permease activity" EXACT []
synonym: "pump activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022809
name: mobile ion carrier activity
namespace: molecular_function
def: "Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
synonym: "ionophore" BROAD []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022810
name: membrane potential driven uniporter activity
namespace: molecular_function
def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
synonym: "porter" BROAD []
is_a: GO:0015292 ! uniporter activity

[Term]
id: GO:0022815
name: obsolete large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term.
synonym: "large uncharged polar molecule transmembrane transporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0022857

[Term]
id: GO:0022818
name: sodium ion uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0022819
name: potassium ion uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0022821
name: solute:potassium antiporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729]
synonym: "potassium ion antiporter activity" EXACT []
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0140828 ! metal cation:monoatomic cation antiporter activity

[Term]
id: GO:0022824
name: transmitter-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ionotropic neurotransmitter receptor activity" NARROW [GOC:bf, GOC:sart]
synonym: "transmitter-gated ion channel activity" BROAD []
is_a: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity
is_a: GO:0022835 ! transmitter-gated channel activity

[Term]
id: GO:0022825
name: obsolete copper-exporting ATPase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined.
synonym: "copper-exporting ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0043682

[Term]
id: GO:0022828
name: obsolete phosphorylation-gated channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: The reason for obsoletion is that there is no evidence that this function exists.
is_obsolete: true

[Term]
id: GO:0022829
name: wide pore channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "gap junction activity" NARROW []
synonym: "non-gated, wide pore channel activity" EXACT []
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022831
name: narrow pore, gated channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ion channels" RELATED []
xref: Wikipedia:Ion_channels
is_a: GO:0022842 ! narrow pore channel activity

[Term]
id: GO:0022832
name: voltage-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022834
name: ligand-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022835
name: transmitter-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "extracellular substance gated channel activity" EXACT []
synonym: "neurotransmitter-gated channel activity" EXACT []
is_a: GO:0022834 ! ligand-gated channel activity
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0022836
name: gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport]
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022839
name: monoatomic ion-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport]
synonym: "ion gated channel activity" BROAD []
synonym: "monoatomic ion gated channel activity" EXACT []
is_a: GO:0022834 ! ligand-gated channel activity

[Term]
id: GO:0022840
name: leak channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022842 ! narrow pore channel activity

[Term]
id: GO:0022841
name: potassium ion leak channel activity
namespace: molecular_function
def: "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022840 ! leak channel activity

[Term]
id: GO:0022842
name: narrow pore channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022843
name: voltage-gated monoatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
synonym: "voltage-gated cation channel activity" BROAD []
xref: Reactome:R-HSA-2534378 "Hv1 Mediated H+ Permeability"
xref: Reactome:R-HSA-6788999 "HV1-mediated H+ transfer"
is_a: GO:0005244 ! voltage-gated monoatomic ion channel activity
is_a: GO:0005261 ! monoatomic cation channel activity

[Term]
id: GO:0022848
name: acetylcholine-gated monoatomic cation-selective channel activity
namespace: molecular_function
alt_id: GO:0004889
alt_id: GO:0016904
def: "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]
synonym: "acetylcholine-activated cation-selective channel activity" EXACT []
synonym: "acetylcholine-gated cation channel activity" EXACT []
synonym: "acetylcholine-gated cation-selective channel activity" BROAD []
synonym: "ionotropic acetylcholine receptor activity" EXACT []
synonym: "nAChR" EXACT []
synonym: "nicotinergic acetylcholine receptor activity" EXACT []
synonym: "nicotinic acetylcholine-activated cation-selective channel activity" EXACT [GOC:bf]
is_a: GO:0005231 ! excitatory extracellular ligand-gated monoatomic ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity
is_a: GO:1904315 ! transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

[Term]
id: GO:0022849
name: glutamate-gated calcium ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0004970 ! glutamate-gated receptor activity
is_a: GO:0099604 ! ligand-gated calcium channel activity

[Term]
id: GO:0022850
name: serotonin-gated monoatomic cation channel activity
namespace: molecular_function
alt_id: GO:0005232
def: "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, PMID:12867984]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'.
synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW []
synonym: "serotonin-activated cation-selective channel activity" EXACT []
synonym: "serotonin-gated cation channel activity" NARROW []
synonym: "serotonin-gated cation-selective channel activity" BROAD []
synonym: "serotonin-gated monoatomic cation-selective channel activity" EXACT []
xref: Reactome:R-HSA-9648983 "HTR3A pentamer:5HT transports Na+,K+,Ca2+"
xref: Reactome:R-HSA-975311 "HTR3 pentamers:5HT transport Na+,K+,Ca2+"
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity
is_a: GO:0099589 ! serotonin receptor activity

[Term]
id: GO:0022851
name: GABA-gated chloride ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity

[Term]
id: GO:0022852
name: glycine-gated chloride ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity

[Term]
id: GO:0022853
name: active monoatomic ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
synonym: "active ion transmembrane transporter activity" BROAD []
is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0022854
name: obsolete active large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term.
synonym: "active large uncharged polar molecule transmembrane transporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0022804

[Term]
id: GO:0022855
name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "glucose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0022856
name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sorbitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015576 ! sorbitol transmembrane transporter activity

[Term]
id: GO:0022857
name: transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005386
alt_id: GO:0015563
alt_id: GO:0015646
alt_id: GO:0022891
alt_id: GO:0022892
def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "substrate-specific transmembrane transporter activity" RELATED []
synonym: "substrate-specific transporter activity" RELATED []
synonym: "uptake permease activity" RELATED []
synonym: "uptake transmembrane transporter activity" RELATED []
xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61"
xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate"
xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics"
xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate"
xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA"
xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome"
xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol"
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0022858
name: alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0022859
name: obsolete dephosphorylation-gated channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: The reason for obsoletion is that there is no evidence that this function exists.
is_obsolete: true

[Term]
id: GO:0022865
name: obsolete transmembrane electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5]
comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process.
is_obsolete: true

[Term]
id: GO:0022866
name: obsolete transmembrane 1-electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. Enables transfer of one electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B]
comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process.
synonym: "transmembrane one-electron transfer carrier" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0022867
name: obsolete transmembrane 2-electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. Enables transfer of two electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A]
comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process.
synonym: "transmembrane two-electron transfer carrier" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0022869
name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "lactose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015155 ! lactose transmembrane transporter activity

[Term]
id: GO:0022870
name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "mannose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0022871
name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, PMID:10613875, RHEA:49296]
synonym: "sorbose PTS transporter activity" EXACT []
xref: EC:2.7.1.206
xref: MetaCyc:RXN-15094
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019194 ! sorbose transmembrane transporter activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0022872
name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "mannitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015575 ! mannitol transmembrane transporter activity

[Term]
id: GO:0022873
name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "maltose PTS transporter activity" EXACT []
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022874
name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "cellobiose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019191 ! cellobiose transmembrane transporter activity

[Term]
id: GO:0022875
name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "galactitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015577 ! galactitol transmembrane transporter activity

[Term]
id: GO:0022876
name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "galactosamine PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019196 ! galactosamine transmembrane transporter activity

[Term]
id: GO:0022877
name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "fructose PTS transporter activity" EXACT []
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022878
name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sucrose PTS transporter activity" EXACT []
xref: MetaCyc:SUCROSEPHOSPHO-RXN
xref: RHEA:49236
is_a: GO:0008515 ! sucrose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022879
name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "trehalose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015574 ! trehalose transmembrane transporter activity

[Term]
id: GO:0022880
name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "N-acetylglucosamine PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity

[Term]
id: GO:0022881
name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "N-acetylgalactosamine PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0022882
name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "beta-glucoside PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity

[Term]
id: GO:0022883
name: zinc efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "zinc efflux permease activity" EXACT []
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0046583 ! monoatomic cation efflux transmembrane transporter activity

[Term]
id: GO:0022884
name: macromolecule transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022885
name: bacteriocin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a bacteriocin from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0042910 ! xenobiotic transmembrane transporter activity

[Term]
id: GO:0022886
name: channel-forming ionophore activity
namespace: molecular_function
def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ionophore activity" BROAD []
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022889
name: obsolete serine transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729, RHEA:35031]
comment: This term was obsoleted because is is redundant with L-serine transmembrane transporter activity ; GO:0015194.
is_obsolete: true
consider: GO:0015194
consider: GO:0042945

[Term]
id: GO:0022890
name: inorganic cation transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015077
alt_id: GO:0015082
alt_id: GO:0072509
alt_id: GO:0072510
def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah]
synonym: "divalent inorganic cation transmembrane transporter activity" NARROW []
synonym: "monovalent inorganic cation transmembrane transporter activity" NARROW []
synonym: "trivalent inorganic cation transmembrane transporter activity" NARROW []
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity

[Term]
id: GO:0022893
name: low-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015510
def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
synonym: "low-affinity tryptophan permease activity" RELATED []
is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity

[Term]
id: GO:0022894
name: intermediate conductance calcium-activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
synonym: "IK calcium-activated potassium channel activity" EXACT []
synonym: "IK KCa channels" EXACT []
synonym: "intermediate conductance KCa channels" EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0022897
name: obsolete proton-dependent peptide secondary active transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport]
comment: This term was obsoleted because it does not define a specific transport mechanism.
synonym: "hydrogen/oligopeptide symporter" RELATED []
is_obsolete: true

[Term]
id: GO:0022898
name: regulation of transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]
subset: gocheck_obsoletion_candidate
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0034762 ! regulation of transmembrane transport

[Term]
id: GO:0022900
name: electron transport chain
namespace: biological_process
def: "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]
subset: goslim_pir
xref: Wikipedia:Electron_transport_chain
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0022904
name: respiratory electron transport chain
namespace: biological_process
def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]
synonym: "6-phosphofructokinase reduction" RELATED []
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "dihydrolipoamide reduction" RELATED []
synonym: "dihydrolipoylprotein reduction" RELATED []
synonym: "dihydropteridine reduction" RELATED []
synonym: "electron transfer" EXACT []
synonym: "other pathways of electron transport" RELATED []
synonym: "oxidized glutathione reduction" RELATED []
synonym: "protein-disulfide reduction" RELATED []
xref: Wikipedia:Electron_transfer
is_a: GO:0022900 ! electron transport chain
relationship: part_of GO:0045333 ! cellular respiration

[Term]
id: GO:0023002
name: nuclear migration to embryo sac poles
namespace: biological_process
def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X]
synonym: "nuclear migration to female gametophyte poles" EXACT []
synonym: "nuclear migration to megagametophyte poles" EXACT []
synonym: "nucleus migration to embryo sac poles" EXACT []
synonym: "nucleus migration to female gametophyte poles" EXACT []
synonym: "nucleus migration to megagametophyte poles" EXACT []
is_a: GO:0009562 ! embryo sac nuclear migration

[Term]
id: GO:0023003
name: nuclear migration to the embryo sac center
namespace: biological_process
def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X]
synonym: "nuclear migration to the embryo sac centre" EXACT []
synonym: "nuclear migration to the female gametophyte center" EXACT []
synonym: "nuclear migration to the female gametophyte centre" EXACT []
synonym: "nuclear migration to the megagametophyte center" EXACT []
synonym: "nuclear migration to the megagametophyte centre" EXACT []
synonym: "nucleus migration to the female gametophyte center" EXACT []
synonym: "nucleus migration to the female gametophyte centre" EXACT []
is_a: GO:0009562 ! embryo sac nuclear migration

[Term]
id: GO:0023004
name: obsolete activation of dopamine receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "activation of dopamine receptor signaling pathway" EXACT []
synonym: "activation of dopamine receptor signalling pathway" EXACT [GOC:mah]
synonym: "initiation of dopamine receptor signaling pathway" RELATED []
synonym: "stimulation of dopamine receptor signaling pathway" EXACT []
is_obsolete: true
consider: GO:0060161

[Term]
id: GO:0023005
name: obsolete signal initiation by neurotransmitter
namespace: biological_process
def: "OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by neurotransmitter" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0030594

[Term]
id: GO:0023006
name: obsolete signal initiation by amino acid
namespace: biological_process
def: "OBSOLETE. The process in which an amino acid signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by amino acid" EXACT []
is_obsolete: true
consider: GO:0007215
consider: GO:0008066
consider: GO:0071230

[Term]
id: GO:0023007
name: obsolete ligand binding to T cell receptor
namespace: biological_process
def: "OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal]
comment: This term was made obsolete because it is describing a binding molecular function.
synonym: "ligand binding to T cell receptor" EXACT []
is_obsolete: true
consider: GO:0042101
consider: GO:0042608
consider: GO:0050852

[Term]
id: GO:0023009
name: obsolete initiation of T cell receptor signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal causes activation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "initiation of T cell receptor signaling" EXACT []
synonym: "initiation of T cell receptor signalling" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0038023
consider: GO:0042101
consider: GO:0048018
consider: GO:0050852

[Term]
id: GO:0023010
name: obsolete regulation of initiation of T cell receptor signaling
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "regulation of initiation of T cell receptor signaling" EXACT []
synonym: "regulation of initiation of T cell receptor signalling" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0050856

[Term]
id: GO:0023011
name: obsolete positive regulation of initiation of T cell receptor signaling
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "positive regulation of initiation of T cell receptor signaling" EXACT []
synonym: "positive regulation of initiation of T cell receptor signalling" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0050862

[Term]
id: GO:0023012
name: obsolete initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor
namespace: biological_process
def: "OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because it is describing a binding molecular function.
synonym: "initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor" EXACT []
synonym: "initiation of T cell receptor signalling by binding of a MHC complex to T cell receptor" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0042101
consider: GO:0050852

[Term]
id: GO:0023017
name: obsolete signal transmission via diffusible molecule
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via a diffusible molecule." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via diffusible molecule" EXACT []
synonym: "signaling via diffusible mediator" EXACT []
is_obsolete: true
consider: GO:0007267

[Term]
id: GO:0023018
name: obsolete T cell activation of signal transmission via diffusible molecule
namespace: biological_process
def: "OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "T cell activation of signal transmission via diffusible molecule" EXACT []
is_obsolete: true

[Term]
id: GO:0023019
name: signal transduction involved in regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf]
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0010468 ! regulation of gene expression

[Term]
id: GO:0023020
name: obsolete regulation of gene expression as a consequence of T cell signal transmission
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "regulation of gene expression as a consequence of T cell signal transmission" EXACT []
is_obsolete: true
consider: GO:0023019

[Term]
id: GO:0023021
name: termination of signal transduction
namespace: biological_process
def: "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]
comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn.
is_a: GO:0009968 ! negative regulation of signal transduction

[Term]
id: GO:0023022
name: termination of T cell signal transduction
namespace: biological_process
def: "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]
is_a: GO:0023021 ! termination of signal transduction
is_a: GO:0050860 ! negative regulation of T cell receptor signaling pathway
relationship: part_of GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0023023
name: MHC protein complex binding
namespace: molecular_function
def: "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0023024
name: MHC class I protein complex binding
namespace: molecular_function
def: "Binding to a class I major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023023 ! MHC protein complex binding

[Term]
id: GO:0023025
name: MHC class Ib protein complex binding
namespace: molecular_function
def: "Binding to a class Ib major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023023 ! MHC protein complex binding

[Term]
id: GO:0023026
name: MHC class II protein complex binding
namespace: molecular_function
def: "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023023 ! MHC protein complex binding

[Term]
id: GO:0023027
name: MHC class I protein binding, via antigen binding groove
namespace: molecular_function
def: "Binding to a major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw]
is_a: GO:0042288 ! MHC class I protein binding
relationship: part_of GO:0023024 ! MHC class I protein complex binding

[Term]
id: GO:0023028
name: MHC class I protein binding, via lateral surface
namespace: molecular_function
def: "Binding to a major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal, GOC:vw]
is_a: GO:0042288 ! MHC class I protein binding

[Term]
id: GO:0023029
name: MHC class Ib protein binding
namespace: molecular_function
def: "Binding to a major histocompatibility complex class Ib molecules." [GOC:mtg_signal, GOC:vw]
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0023030
name: MHC class Ib protein binding, via antigen binding groove
namespace: molecular_function
def: "Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023029 ! MHC class Ib protein binding
relationship: part_of GO:0023025 ! MHC class Ib protein complex binding

[Term]
id: GO:0023031
name: MHC class Ib protein binding, via lateral surface
namespace: molecular_function
def: "Binding to a major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023029 ! MHC class Ib protein binding

[Term]
id: GO:0023035
name: CD40 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017]
synonym: "CD40 signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0023036
name: obsolete initiation of signal transduction
namespace: biological_process
def: "OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous. Note that this term was intended for the annotation of both ligands and receptors.
synonym: "initiation of signal transduction" EXACT []
synonym: "signal reception" RELATED []
is_obsolete: true
consider: GO:0007165
consider: GO:0038023
consider: GO:0048018

[Term]
id: GO:0023037
name: obsolete signal initiation by light
namespace: biological_process
def: "OBSOLETE. The process in which a light signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by light" EXACT []
is_obsolete: true
consider: GO:0009785
consider: GO:0009881
consider: GO:0010017
consider: GO:0010018
consider: GO:0010161

[Term]
id: GO:0023038
name: obsolete signal initiation by diffusible mediator
namespace: biological_process
def: "OBSOLETE. The process in which a diffusible signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by diffusible mediator" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0038001
consider: GO:0038023
consider: GO:0048018

[Term]
id: GO:0023039
name: obsolete signal initiation by physical damage
namespace: biological_process
def: "OBSOLETE. The process in which a physical damage signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by physical damage" EXACT []
is_obsolete: true
consider: GO:0033554
consider: GO:0038023

[Term]
id: GO:0023040
name: obsolete signaling via ionic flux
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via ionic flux" EXACT []
synonym: "signalling via ionic flux" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0023052

[Term]
id: GO:0023041
name: neuronal signal transduction
namespace: biological_process
def: "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal]
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0023042
name: obsolete signaling via protein/peptide mediator
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via protein/peptide mediator" EXACT []
synonym: "signalling via protein/peptide mediator" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0023052

[Term]
id: GO:0023043
name: obsolete signaling via lipid mediator
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via lipid mediator" EXACT []
synonym: "signalling via lipid mediator" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0023044
name: obsolete signaling via chemical mediator
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via chemical mediator" EXACT []
synonym: "signalling via chemical mediator" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0023052

[Term]
id: GO:0023047
name: obsolete signal initiation by chemical mediator
namespace: biological_process
def: "OBSOLETE. The process in which a chemical signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by chemical mediator" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0038023
consider: GO:0070887

[Term]
id: GO:0023048
name: obsolete signal initiation by lipid mediator
namespace: biological_process
def: "OBSOLETE. The process in which a lipid signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by lipid mediator" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0045125

[Term]
id: GO:0023049
name: obsolete signal initiation by protein/peptide mediator
namespace: biological_process
def: "OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by protein/peptide mediator" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0038023
consider: GO:0048018

[Term]
id: GO:0023050
name: obsolete consequence of signal transmission
namespace: biological_process
def: "OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signal]
comment: This term was made obsolete because the term is no longer needed.
synonym: "consequence of signal transmission" EXACT []
synonym: "signal termination" EXACT []
is_obsolete: true

[Term]
id: GO:0023051
name: regulation of signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "regulation of signaling process" RELATED [GOC:bf]
synonym: "regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0023052 ! signaling

[Term]
id: GO:0023052
name: signaling
namespace: biological_process
alt_id: GO:0023046
alt_id: GO:0044700
def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
subset: goslim_agr
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "biological signaling" EXACT []
synonym: "signaling process" EXACT []
synonym: "signalling" EXACT []
synonym: "signalling process" RELATED [GOC:mah]
synonym: "single organism signaling" RELATED []
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0023053
name: obsolete signal initiation by mechanical effect
namespace: biological_process
def: "OBSOLETE. The process in which a mechanical signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by mechanical effect" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0038023
consider: GO:0071260

[Term]
id: GO:0023054
name: obsolete signal initiation by stretch effect
namespace: biological_process
def: "OBSOLETE. The process in which a stretch signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by stretch effect" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0038023

[Term]
id: GO:0023055
name: obsolete signal initiation by peptide hormone
namespace: biological_process
def: "OBSOLETE. The process in which a signal is initiated by a peptide hormone." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by peptide hormone" EXACT []
is_obsolete: true
consider: GO:0004879
consider: GO:0005179
consider: GO:0009755

[Term]
id: GO:0023056
name: positive regulation of signaling
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "positive regulation of signaling process" RELATED [GOC:bf]
synonym: "positive regulation of signalling process" EXACT [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0023052 ! signaling

[Term]
id: GO:0023057
name: negative regulation of signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "negative regulation of signaling process" RELATED [GOC:bf]
synonym: "negative regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0023052 ! signaling

[Term]
id: GO:0023058
name: adaptation of signaling pathway
namespace: biological_process
def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal]
synonym: "adaptation of signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction

[Term]
id: GO:0023059
name: positive adaptation of signaling pathway
namespace: biological_process
def: "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal]
synonym: "positive adaptation of signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0023058 ! adaptation of signaling pathway

[Term]
id: GO:0023060
name: obsolete signal transmission
namespace: biological_process
def: "OBSOLETE. The process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "signal transmission" EXACT []
is_obsolete: true
consider: GO:0023052

[Term]
id: GO:0023061
name: signal release
namespace: biological_process
def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal]
synonym: "signal secretion" EXACT [GOC:bf]
is_a: GO:0032940 ! secretion by cell
relationship: part_of GO:0007267 ! cell-cell signaling

[Term]
id: GO:0023062
name: obsolete signal transmission via transcytosis
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [GOC:mtg_signal, ISBN:0716731363]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via transcytosis" EXACT []
is_obsolete: true
consider: GO:0023052
consider: GO:0045056

[Term]
id: GO:0023065
name: obsolete signal transmission via blood
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via blood." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via blood" EXACT []
is_obsolete: true
consider: GO:0010232
consider: GO:0023052

[Term]
id: GO:0023066
name: obsolete signal transmission via vascular system
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the vascular system." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via vascular system" EXACT []
is_obsolete: true
consider: GO:0010232
consider: GO:0023052

[Term]
id: GO:0023067
name: obsolete signal transmission via lymphatic system
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the lymphatic system." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via lymphatic system" EXACT []
is_obsolete: true
consider: GO:0023052

[Term]
id: GO:0023068
name: obsolete signal transmission via phloem
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the phloem." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via phloem" EXACT []
is_obsolete: true
consider: GO:0010233
consider: GO:0023052

[Term]
id: GO:0023069
name: obsolete signal transmission via xylem
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the xylem." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via xylem" EXACT []
is_obsolete: true
consider: GO:0010232
consider: GO:0023052

[Term]
id: GO:0023070
name: obsolete signal transmission via air
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the air." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via air" EXACT []
is_obsolete: true

[Term]
id: GO:0030001
name: metal ion transport
namespace: biological_process
alt_id: GO:0070838
alt_id: GO:0070839
def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "divalent metal ion export" NARROW []
synonym: "divalent metal ion transport" NARROW []
synonym: "heavy metal ion transport" NARROW []
synonym: "metal ion export" NARROW []
is_a: GO:0006812 ! monoatomic cation transport

[Term]
id: GO:0030002
name: intracellular monoatomic anion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic anions within a cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom." [GOC:ceb, GOC:mah]
synonym: "cellular anion homeostasis" BROAD []
synonym: "cellular monoatomic anion homeostasis" EXACT []
is_a: GO:0006873 ! intracellular monoatomic ion homeostasis
is_a: GO:0055081 ! monoatomic anion homeostasis

[Term]
id: GO:0030003
name: intracellular monoatomic cation homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:mah]
synonym: "cellular cation homeostasis" BROAD []
synonym: "cellular monoatomic cation homeostasis" EXACT []
is_a: GO:0006873 ! intracellular monoatomic ion homeostasis
is_a: GO:0055080 ! monoatomic cation homeostasis

[Term]
id: GO:0030004
name: obsolete cellular monovalent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0030003

[Term]
id: GO:0030005
name: obsolete cellular di-, tri-valent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah]
synonym: "cellular di-, tri-valent inorganic cation homeostasis" EXACT []
is_obsolete: true
consider: GO:0030003

[Term]
id: GO:0030006
name: obsolete heavy cellular metal ion homeostasis
namespace: biological_process
def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy cellular metal ion homeostasis" EXACT []
is_obsolete: true
consider: GO:0030003

[Term]
id: GO:0030007
name: intracellular potassium ion homeostasis
namespace: biological_process
alt_id: GO:0017079
def: "A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell." [GOC:mah]
synonym: "cellular potassium ion homeostasis" EXACT []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0055075 ! potassium ion homeostasis

[Term]
id: GO:0030008
name: TRAPP complex
namespace: cellular_component
def: "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]
synonym: "transport protein particle" EXACT []
synonym: "transport protein particle complex" EXACT [GOC:bhm]
synonym: "TRAPP1" NARROW [GOC:vw]
synonym: "TRAPP2" NARROW [GOC:vw]
xref: Wikipedia:TRAPP_complex
is_a: GO:0099023 ! vesicle tethering complex
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0030009
name: obsolete complement factor H activity
namespace: molecular_function
def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "complement factor H activity" EXACT []
is_obsolete: true
consider: GO:0006956

[Term]
id: GO:0030010
name: establishment of cell polarity
namespace: biological_process
alt_id: GO:0000283
alt_id: GO:0030468
def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
synonym: "bud site selection/establishment of cell polarity" NARROW []
synonym: "cell polarization" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030011
name: maintenance of cell polarity
namespace: biological_process
alt_id: GO:0030013
alt_id: GO:0030469
def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030014
name: CCR4-NOT complex
namespace: cellular_component
def: "The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0030015
name: CCR4-NOT core complex
namespace: cellular_component
def: "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]
is_a: GO:0140535 ! intracellular protein-containing complex
relationship: part_of GO:0030014 ! CCR4-NOT complex

[Term]
id: GO:0030016
name: myofibril
namespace: cellular_component
def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
xref: Wikipedia:Myofibril
is_a: GO:0043292 ! contractile muscle fiber

[Term]
id: GO:0030017
name: sarcomere
namespace: cellular_component
def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
xref: Wikipedia:Sarcomere
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0030018
name: Z disc
namespace: cellular_component
def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
synonym: "Z band" EXACT []
synonym: "Z disk" EXACT []
synonym: "Z line" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031674 ! I band

[Term]
id: GO:0030019
name: obsolete tryptase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "lung tryptase activity" NARROW []
synonym: "mast cell neutral proteinase activity" RELATED []
synonym: "mast cell protease II activity" NARROW []
synonym: "mast cell proteinase II" RELATED []
synonym: "mast cell serine proteinase II" RELATED []
synonym: "mast cell serine proteinase tryptase activity" RELATED []
synonym: "mast cell tryptase activity" NARROW []
synonym: "pituitary tryptase activity" NARROW []
synonym: "rat mast cell protease II" RELATED []
synonym: "skin tryptase activity" NARROW []
synonym: "tryptase activity" EXACT []
synonym: "tryptase M" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030020
name: extracellular matrix structural constituent conferring tensile strength
namespace: molecular_function
def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194]
comment: Extracellular matrix collagen proteins may be annotated to this term. PMID:29632050, PMID:24443019
synonym: "core extracellular matrix" BROAD []
synonym: "core matrisome" BROAD []
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030021
name: extracellular matrix structural constituent conferring compression resistance
namespace: molecular_function
def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194]
comment: Extracellular matrix proteoglycans may be annotated to this term. PMID:8346704
synonym: "core extracellular matrix" BROAD []
synonym: "core matrisome" BROAD []
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030022
name: obsolete adhesive extracellular matrix constituent
namespace: molecular_function
def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "adhesive extracellular matrix constituent" EXACT []
is_obsolete: true
consider: GO:0030674
consider: GO:0031012
consider: GO:0050839
consider: GO:0050840

[Term]
id: GO:0030023
name: extracellular matrix constituent conferring elasticity
namespace: molecular_function
def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194]
comment: Extracellular matrix elastin proteins may be annotated to this term. PMID:27009176, PMID:24443019
synonym: "core extracellular matrix" BROAD []
synonym: "core matrisome" BROAD []
synonym: "elastin" RELATED []
is_a: GO:0005201 ! extracellular matrix structural constituent
is_a: GO:0097493 ! structural molecule activity conferring elasticity

[Term]
id: GO:0030026
name: intracellular manganese ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell." [GOC:mah]
synonym: "cellular manganese ion homeostasis" EXACT []
synonym: "manganese homeostasis" BROAD []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0055071 ! manganese ion homeostasis

[Term]
id: GO:0030027
name: lamellipodium
namespace: cellular_component
def: "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]
xref: Wikipedia:Lamellipodia
is_a: GO:0120025 ! plasma membrane bounded cell projection
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0030029
name: actin filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "microfilament-based process" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0030030
name: cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917]
subset: goslim_prokaryote
synonym: "cell projection organisation" EXACT []
synonym: "cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0030031
name: cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171]
synonym: "cell projection biogenesis" RELATED [GOC:mah]
synonym: "formation of a cell surface projection" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0030032
name: lamellipodium assembly
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
synonym: "lamellipodium biogenesis" RELATED [GOC:mah]
synonym: "lamellipodium biosynthesis" EXACT []
synonym: "lamellipodium formation" EXACT []
is_a: GO:0097581 ! lamellipodium organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0030033
name: microvillus assembly
namespace: biological_process
def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194]
synonym: "microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032528 ! microvillus organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0030034
name: microvillar actin bundle assembly
namespace: biological_process
def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah]
is_a: GO:0030046 ! parallel actin filament bundle assembly
relationship: part_of GO:0030033 ! microvillus assembly

[Term]
id: GO:0030035
name: microspike assembly
namespace: biological_process
def: "Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell." [ISBN:0815316194, PMID:11429692, PMID:12153987, PMID:19095735]
comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. For the assembly of filopodia, use 'filopodium assembly ; GO:0046847'.
synonym: "microspike biogenesis" RELATED [GOC:mah]
synonym: "microspike biosynthesis" EXACT []
synonym: "microspike formation" EXACT []
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0030036
name: actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pombe
synonym: "actin cytoskeleton organisation" EXACT []
synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "actin modulating activity" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0030037
name: obsolete actin filament reorganization involved in cell cycle
namespace: biological_process
def: "OBSOLETE. The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
comment: This term was obsoleted because it is a pre-composed term.
synonym: "actin filament reorganisation involved in cell cycle" EXACT [GOC:mah]
synonym: "actin filament reorganization during cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0007015

[Term]
id: GO:0030038
name: contractile actin filament bundle assembly
namespace: biological_process
def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0030039
name: obsolete DNA unwinding factor
namespace: molecular_function
alt_id: GO:0017152
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA unwinding factor" EXACT []
is_obsolete: true
replaced_by: GO:0006268

[Term]
id: GO:0030041
name: actin filament polymerization
namespace: biological_process
def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
synonym: "actin polymerization" EXACT []
synonym: "actin polymerizing activity" RELATED []
is_a: GO:0008154 ! actin polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0030042
name: actin filament depolymerization
namespace: biological_process
def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
synonym: "actin depolymerization" EXACT []
synonym: "actin depolymerizing activity" RELATED []
is_a: GO:0008154 ! actin polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0030043
name: actin filament fragmentation
namespace: biological_process
def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194]
is_a: GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030046
name: parallel actin filament bundle assembly
namespace: biological_process
def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0030047
name: actin modification
namespace: biological_process
alt_id: GO:0007013
def: "Covalent modification of an actin molecule." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0030048
name: actin filament-based movement
namespace: biological_process
def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0030049
name: muscle filament sliding
namespace: biological_process
def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194]
is_a: GO:0033275 ! actin-myosin filament sliding
relationship: part_of GO:0006936 ! muscle contraction

[Term]
id: GO:0030050
name: vesicle transport along actin filament
namespace: biological_process
def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah]
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport
is_a: GO:0099518 ! vesicle cytoskeletal trafficking

[Term]
id: GO:0030051
name: obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase
namespace: molecular_function
def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product and not a function.
synonym: "FK506 binding protein" RELATED []
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" EXACT []
synonym: "FKBP" RELATED []
is_obsolete: true
consider: GO:0003755
consider: GO:0005528

[Term]
id: GO:0030052
name: obsolete parvulin
namespace: molecular_function
def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732]
comment: This term was made obsolete because it describes a gene product.
synonym: "parvulin" EXACT []
is_obsolete: true
replaced_by: GO:0003755

[Term]
id: GO:0030053
name: obsolete immunophilin
namespace: molecular_function
def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "immunophilin" EXACT []
is_obsolete: true
consider: GO:0003755

[Term]
id: GO:0030054
name: cell junction
namespace: cellular_component
def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_flybase_ribbon
xref: Wikipedia:Cell_junction
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0030055
name: cell-substrate junction
namespace: cellular_component
def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]
synonym: "cell-matrix junction" EXACT []
is_a: GO:0070161 ! anchoring junction

[Term]
id: GO:0030056
name: hemidesmosome
namespace: cellular_component
def: "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195]
synonym: "epidermal attachment structure" NARROW [GOC:kmv]
synonym: "fibrous organelle" NARROW [GOC:kmv, PMID:20205195]
synonym: "hemi-adherens junction" RELATED []
synonym: "trans-epithelial attachment" NARROW [GOC:kmv, PMID:20205195]
xref: Wikipedia:Hemidesmosome
is_a: GO:0030055 ! cell-substrate junction

[Term]
id: GO:0030057
name: desmosome
namespace: cellular_component
def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181]
synonym: "macula adherens" EXACT []
synonym: "spot desmosome" EXACT []
xref: Wikipedia:Desmosome
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0030058
name: aliphatic amine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+." [RHEA:51128]
synonym: "amine dehydrogenase activity" BROAD []
synonym: "amine: (acceptor) oxidoreductase (deaminating)" RELATED []
synonym: "MADH activity" RELATED []
synonym: "methylamine dehydrogenase activity" RELATED []
synonym: "primary-amine dehydrogenase activity" BROAD []
synonym: "primary-amine:acceptor oxidoreductase (deaminating)" RELATED []
xref: RHEA:51128
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0030059
name: aralkylamine dehydrogenase (azurin) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]." [PMID:10506161, RHEA:47796]
synonym: "aralkylamine:(azurin) oxidoreductase (deaminating) activity" EXACT [EC:1.4.9.2]
synonym: "aromatic amine dehydrogenase (azurin) activity" EXACT [EC:1.4.9.2]
xref: EC:1.4.9.2
xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN
xref: RHEA:47796
is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor

[Term]
id: GO:0030060
name: L-malate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [RHEA:21432]
synonym: "(S)-malate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.37]
synonym: "L-malate-NAD+ oxidoreductase activity" RELATED [EC:1.1.1.37]
synonym: "malate (NAD) dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "malic acid dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "malic dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "MDH" RELATED [EC:1.1.1.37]
synonym: "NAD-dependent malate dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "NAD-dependent malic dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "NAD-L-malate dehydrogenase activity" EXACT []
synonym: "NAD-linked malate dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "NAD-malate dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "NAD-malic dehydrogenase activity" RELATED [EC:1.1.1.37]
synonym: "NAD-specific malate dehydrogenase activity" RELATED [EC:1.1.1.37]
xref: EC:1.1.1.37
xref: MetaCyc:MALATE-DEH-RXN
xref: Reactome:R-HSA-70979 "MDH2 dimer dehydrogenates MAL"
xref: Reactome:R-HSA-9856871 "MDH1 reduces OA"
xref: RHEA:21432
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030061
name: mitochondrial crista
namespace: cellular_component
def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "cristae" BROAD [NIF_Subcellular:sao333328131]
synonym: "mitochondrial cristae" EXACT []
xref: NIF_Subcellular:sao333328131
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0030062
name: obsolete mitochondrial tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "OBSOLETE. Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]
comment: The reason for obsoletion is that this term is unnecessarily taxon-specific.
synonym: "TCA cycle enzyme complex" BROAD []
is_obsolete: true
replaced_by: GO:0045239

[Term]
id: GO:0030063
name: obsolete murein sacculus
namespace: cellular_component
def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "murein sacculus" EXACT []
synonym: "peptidoglycan layer" EXACT []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0030064
name: obsolete cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "cell wall inner membrane" EXACT []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0030066
name: obsolete cytochrome b6
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b-563" RELATED []
synonym: "cytochrome b6" EXACT []
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0030067
name: obsolete respiratory chain cytochrome b6
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "respiratory chain cytochrome b6" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0030068
name: obsolete lytic viral life cycle
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "lytic viral life cycle" EXACT []
is_obsolete: true
consider: GO:0019058
consider: GO:0044659

[Term]
id: GO:0030070
name: insulin processing
namespace: biological_process
def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732]
is_a: GO:0016486 ! peptide hormone processing
is_a: GO:1901142 ! insulin metabolic process

[Term]
id: GO:0030071
name: regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mah]
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
relationship: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle

[Term]
id: GO:0030072
name: peptide hormone secretion
namespace: biological_process
def: "The regulated release of a peptide hormone from a cell." [GOC:mah]
is_a: GO:0002790 ! peptide secretion
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0030073
name: insulin secretion
namespace: biological_process
def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732]
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030074
name: obsolete thylakoid (sensu Proteobacteria)
namespace: cellular_component
def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria.
synonym: "thylakoid (sensu Proteobacteria)" EXACT []
is_obsolete: true
consider: GO:0042716

[Term]
id: GO:0030075
name: bacterial thylakoid
namespace: cellular_component
def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu]
synonym: "plasma membrane-derived thylakoid" EXACT []
is_a: GO:0009579 ! thylakoid

[Term]
id: GO:0030076
name: light-harvesting complex
namespace: cellular_component
def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr]
subset: goslim_pir
synonym: "antenna complex" RELATED []
xref: Wikipedia:Light-harvesting_complex
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0030077
name: plasma membrane light-harvesting complex
namespace: cellular_component
def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030076 ! light-harvesting complex
relationship: part_of GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0030078
name: light-harvesting complex, core complex
namespace: cellular_component
def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr]
is_a: GO:0030077 ! plasma membrane light-harvesting complex

[Term]
id: GO:0030079
name: light-harvesting complex, peripheral complex
namespace: cellular_component
def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr]
is_a: GO:0030077 ! plasma membrane light-harvesting complex

[Term]
id: GO:0030080
name: B875 antenna complex
namespace: cellular_component
def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd]
synonym: "LH1 complex" EXACT []
synonym: "light harvesting complex I" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030078 ! light-harvesting complex, core complex

[Term]
id: GO:0030081
name: B800-820 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]
synonym: "LH3 complex" EXACT []
synonym: "light harvesting complex III" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030082
name: B800-850 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]
synonym: "LH2 complex" EXACT []
synonym: "light harvesting complex II" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030083
name: PSI associated light-harvesting complex I, LHCIa subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030084
name: PSI associated light-harvesting complex I, LHCIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030085
name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475]
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex

[Term]
id: GO:0030086
name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" EXACT []
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030087
name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" EXACT []
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030088
name: obsolete PSII associated light-harvesting complex II, core complex, LHCIId subcomplex
namespace: cellular_component
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" EXACT []
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030089
name: phycobilisome
namespace: cellular_component
def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, PMID:11734882, Wikipedia:Phycobilisome]
xref: Wikipedia:Phycobilisome
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0030091
name: protein repair
namespace: biological_process
def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg]
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0030092
name: obsolete regulation of flagellum assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "regulation of flagella assembly" RELATED [GOC:mah]
synonym: "regulation of flagella biogenesis" RELATED []
synonym: "regulation of flagellum assembly" EXACT []
synonym: "regulation of flagellum biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:1902017
consider: GO:1902208

[Term]
id: GO:0030093
name: chloroplast photosystem I
namespace: cellular_component
def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0009522 ! photosystem I
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex

[Term]
id: GO:0030094
name: plasma membrane-derived photosystem I
namespace: cellular_component
def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jid, GOC:mtg_sensu]
synonym: "plasma membrane photosystem I" EXACT []
is_a: GO:0009522 ! photosystem I
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0030095
name: chloroplast photosystem II
namespace: cellular_component
def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0009523 ! photosystem II
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex

[Term]
id: GO:0030096
name: plasma membrane-derived thylakoid photosystem II
namespace: cellular_component
def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu]
synonym: "plasma membrane photosystem II" EXACT []
is_a: GO:0009523 ! photosystem II
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0030097
name: hemopoiesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
synonym: "blood cell biosynthesis" EXACT []
synonym: "blood cell formation" EXACT []
synonym: "haemopoiesis" EXACT []
synonym: "hematopoiesis" EXACT []
xref: Wikipedia:Haematopoiesis
is_a: GO:0048468 ! cell development

[Term]
id: GO:0030098
name: lymphocyte differentiation
namespace: biological_process
alt_id: GO:0046650
def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "lymphocyte cell differentiation" EXACT []
synonym: "lymphocyte development" RELATED [GOC:add]
synonym: "lymphocytic blood cell differentiation" EXACT []
is_a: GO:0046649 ! lymphocyte activation
is_a: GO:1903131 ! mononuclear cell differentiation

[Term]
id: GO:0030099
name: myeloid cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0030100
name: regulation of endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006897 ! endocytosis

[Term]
id: GO:0030101
name: natural killer cell activation
namespace: biological_process
def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
synonym: "NK cell activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0030103
name: vasopressin secretion
namespace: biological_process
def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030104
name: obsolete water homeostasis
namespace: biological_process
alt_id: GO:0018987
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb]
comment: The reason for obsoletion is that this term does not specify whether the process is intracellular or organism-level.
synonym: "osmoregulation" RELATED []
synonym: "regulation of osmotic pressure" EXACT []
xref: Wikipedia:Osmoregulation
is_obsolete: true
consider: GO:0003091
consider: GO:0009992
consider: GO:0050891

[Term]
id: GO:0030105
name: obsolete anaphylaxis
namespace: biological_process
def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732]
comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism.
synonym: "anaphylaxis" EXACT []
is_obsolete: true
consider: GO:0006955

[Term]
id: GO:0030106
name: obsolete MHC class I receptor activity
namespace: molecular_function
def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971]
comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'.
synonym: "class I major histocompatibility complex antigen" RELATED []
synonym: "major histocompatibility complex class I receptor" EXACT []
synonym: "MHC class I receptor activity" EXACT []
is_obsolete: true
consider: GO:0032393
consider: GO:0042612

[Term]
id: GO:0030107
name: HLA-A specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030108
name: HLA-A specific activating MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032397 ! activating MHC class I receptor activity

[Term]
id: GO:0030109
name: HLA-B specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030110
name: HLA-C specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030111
name: regulation of Wnt signaling pathway
namespace: biological_process
alt_id: GO:0008590
def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of frizzled signaling pathway" EXACT []
synonym: "regulation of frizzled signalling pathway" EXACT []
synonym: "regulation of Wnt receptor signaling pathway" EXACT []
synonym: "regulation of Wnt receptor signalling pathway" EXACT []
synonym: "regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0030112
name: glycocalyx
namespace: cellular_component
def: "A carbohydrate rich layer at the outermost periphery of a cell." [GOC:krc, GOC:mlg, ISBN:0815316208, PMID:28876829]
subset: goslim_pir
xref: Wikipedia:Glycocalyx
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030114
name: slime layer
namespace: cellular_component
def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, Wikipedia:Slime_layer]
xref: Wikipedia:Slime_layer
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0030115
name: S-layer
namespace: cellular_component
def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893]
subset: goslim_pir
xref: Wikipedia:S-layer
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030116
name: glial cell-derived neurotrophic factor receptor binding
namespace: molecular_function
def: "A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors." [GOC:vw, PMID:11476867]
synonym: "glial cell line-derived neurotrophic factor receptor binding" RELATED []
synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0030117
name: membrane coat
namespace: cellular_component
def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0048475 ! coated membrane

[Term]
id: GO:0030118
name: clathrin coat
namespace: cellular_component
alt_id: GO:0016190
def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]
synonym: "clathrin cage" EXACT []
xref: NIF_Subcellular:sao879919129
xref: Wikipedia:Clathrin
is_a: GO:0030117 ! membrane coat

[Term]
id: GO:0030119
name: AP-type membrane coat adaptor complex
namespace: cellular_component
def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]
subset: goslim_pir
synonym: "clathrin adaptor" RELATED []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030117 ! membrane coat

[Term]
id: GO:0030120
name: vesicle coat
namespace: cellular_component
def: "A membrane coat found on a coated vesicle." [GOC:mah]
xref: NIF_Subcellular:sao1177708494
is_a: GO:0030117 ! membrane coat
relationship: part_of GO:0030662 ! coated vesicle membrane

[Term]
id: GO:0030121
name: AP-1 adaptor complex
namespace: cellular_component
def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]
synonym: "AP-1 related adapter complex" RELATED []
synonym: "HA1" EXACT []
synonym: "HA1 clathrin adaptor" EXACT []
is_a: GO:0030131 ! clathrin adaptor complex
relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle

[Term]
id: GO:0030122
name: AP-2 adaptor complex
namespace: cellular_component
def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]
synonym: "HA2" EXACT []
synonym: "HA2 clathrin adaptor" EXACT []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle
relationship: part_of GO:0030132 ! clathrin coat of coated pit

[Term]
id: GO:0030123
name: AP-3 adaptor complex
namespace: cellular_component
def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex

[Term]
id: GO:0030124
name: AP-4 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex

[Term]
id: GO:0030125
name: clathrin vesicle coat
namespace: cellular_component
def: "A clathrin coat found on a vesicle." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0030120 ! vesicle coat
relationship: part_of GO:0030665 ! clathrin-coated vesicle membrane

[Term]
id: GO:0030126
name: COPI vesicle coat
namespace: cellular_component
alt_id: GO:0017167
def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]
synonym: "coatomer" EXACT []
is_a: GO:0030120 ! vesicle coat
relationship: part_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0030663 ! COPI-coated vesicle membrane

[Term]
id: GO:0030127
name: COPII vesicle coat
namespace: cellular_component
def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
is_a: GO:0030120 ! vesicle coat
relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane

[Term]
id: GO:0030128
name: clathrin coat of endocytic vesicle
namespace: cellular_component
def: "A clathrin coat found on an endocytic vesicle." [GOC:mah]
synonym: "clathrin coat of endocytotic vesicle" EXACT []
is_a: GO:0030125 ! clathrin vesicle coat
relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane

[Term]
id: GO:0030129
name: clathrin coat of synaptic vesicle
namespace: cellular_component
def: "A clathrin coat found on a synaptic vesicle." [GOC:mah]
is_a: GO:0030125 ! clathrin vesicle coat
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0030130
name: clathrin coat of trans-Golgi network vesicle
namespace: cellular_component
def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
synonym: "clathrin coat of TGN vesicle" EXACT []
is_a: GO:0030125 ! clathrin vesicle coat
relationship: part_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane

[Term]
id: GO:0030131
name: clathrin adaptor complex
namespace: cellular_component
def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex
relationship: part_of GO:0030118 ! clathrin coat

[Term]
id: GO:0030132
name: clathrin coat of coated pit
namespace: cellular_component
def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005905 ! clathrin-coated pit

[Term]
id: GO:0030133
name: transport vesicle
namespace: cellular_component
def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
synonym: "constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi to vacuole transport vesicle" NARROW []
synonym: "Golgi-vacuole transport vesicle" NARROW []
synonym: "secretory vesicle" RELATED []
xref: NIF_Subcellular:sao885490876
is_a: GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030134
name: COPII-coated ER to Golgi transport vesicle
namespace: cellular_component
alt_id: GO:0030138
alt_id: GO:0140045
def: "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]
synonym: "COPII vesicle" RELATED []
synonym: "COPII-associated ER to Golgi transport vesicle" EXACT []
synonym: "COPII-associated vesicle" EXACT []
synonym: "COPII-coated vesicle" EXACT []
synonym: "endoplasmic reticulum to Golgi transport vesicle" RELATED []
synonym: "endoplasmic reticulum-Golgi transport vesicle" RELATED []
synonym: "ER to Golgi constitutive secretory pathway transport vesicle" RELATED []
synonym: "ER to Golgi transport vesicle" RELATED []
synonym: "ER-Golgi transport vesicle" RELATED []
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030135
name: coated vesicle
namespace: cellular_component
alt_id: GO:0005909
def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
subset: goslim_drosophila
xref: NIF_Subcellular:sao1985096626
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0030136
name: clathrin-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
xref: NIF_Subcellular:sao148845161
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030137
name: COPI-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894]
synonym: "coatomer" RELATED []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030139
name: endocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
synonym: "endocytotic transport vesicle" EXACT []
synonym: "endocytotic vesicle" EXACT []
xref: NIF_Subcellular:sao1362520468
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0030140
name: trans-Golgi network transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]
synonym: "TGN transport vesicle" EXACT []
synonym: "trans-Golgi network constitutive secretory pathway transport vesicle" EXACT []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030141
name: secretory granule
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
synonym: "secretory vesicle" BROAD []
is_a: GO:0099503 ! secretory vesicle
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030142
name: COPI-coated Golgi to ER transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah, PMID:22160157]
synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT []
synonym: "Golgi to ER constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT []
synonym: "Golgi-ER transport vesicle" EXACT []
synonym: "retrograde transport vesicle" EXACT [PMID:22160157]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030143
name: COPI-coated inter-Golgi transport vesicle
namespace: cellular_component
alt_id: GO:0005807
def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah]
synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle" EXACT []
xref: NIF_Subcellular:sao1382918459
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030144
name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]
synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155]
synonym: "GnTV activity" RELATED [EC:2.4.1.155]
synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155]
synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.155]
synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155]
synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155]
synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155]
synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155]
xref: EC:2.4.1.155
xref: MetaCyc:2.4.1.155-RXN
xref: Reactome:R-HSA-9696980 "Spike trimer glycoside chains get additional branches"
xref: Reactome:R-HSA-975916 "Addition of GlcNAc to position 5 by MGAT5"
xref: RHEA:16921
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0030145
name: manganese ion binding
namespace: molecular_function
def: "Binding to a manganese ion (Mn)." [GOC:ai]
synonym: "manganese binding" EXACT []
synonym: "Mn binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0030146
name: obsolete diuresis
namespace: biological_process
alt_id: GO:0003076
def: "OBSOLETE. The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "diuresis" EXACT []
synonym: "positive regulation of renal water excretion" EXACT []
synonym: "renal water excretion" BROAD []
xref: Wikipedia:Diuresis
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0030147
name: obsolete natriuresis
namespace: biological_process
def: "OBSOLETE. The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "natriuresis" EXACT []
xref: Wikipedia:Natriuresis
is_obsolete: true
consider: GO:0035815

[Term]
id: GO:0030148
name: sphingolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
synonym: "sphingolipid anabolism" EXACT []
synonym: "sphingolipid biosynthesis" EXACT []
synonym: "sphingolipid formation" EXACT []
synonym: "sphingolipid synthesis" EXACT []
xref: MetaCyc:PWY-5129
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046467 ! membrane lipid biosynthetic process

[Term]
id: GO:0030149
name: sphingolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
synonym: "sphingolipid breakdown" EXACT []
synonym: "sphingolipid catabolism" EXACT []
synonym: "sphingolipid degradation" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046466 ! membrane lipid catabolic process

[Term]
id: GO:0030150
name: protein import into mitochondrial matrix
namespace: biological_process
def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]
synonym: "mitochondrial matrix protein import" EXACT []
synonym: "mitochondrial translocation" BROAD []
synonym: "protein transport into mitochondrial matrix" EXACT []
is_a: GO:0044743 ! protein transmembrane import into intracellular organelle
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:0170036 ! import into the mitochondrion
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0030151
name: molybdenum ion binding
namespace: molecular_function
def: "Binding to a molybdenum ion (Mo)." [GOC:ai]
synonym: "Mo ion binding" EXACT []
synonym: "molybdenum binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0030152
name: bacteriocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732]
synonym: "bacteriocin anabolism" EXACT []
synonym: "bacteriocin biosynthesis" EXACT []
synonym: "bacteriocin formation" EXACT []
synonym: "bacteriocin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0030651 ! peptide antibiotic biosynthetic process
is_a: GO:0046224 ! bacteriocin metabolic process

[Term]
id: GO:0030153
name: bacteriocin immunity
namespace: biological_process
def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732]
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0030154
name: cell differentiation
namespace: biological_process
def: "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
xref: Wikipedia:Cellular_differentiation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0030155
name: regulation of cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]
synonym: "cell adhesion receptor regulator activity" RELATED []
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0030156
name: benzodiazepine receptor binding
namespace: molecular_function
def: "Binding to a peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832]
synonym: "benzodiazepine receptor ligand" NARROW []
synonym: "diazepam binding inhibitor activity" RELATED []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0030157
name: pancreatic juice secretion
namespace: biological_process
def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0022600 ! digestive system process
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0030158
name: protein xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26]
synonym: "peptide O-xylosyltransferase activity" EXACT []
synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26]
synonym: "UDP-D-xylose:core protein xylosyltransferase activity" RELATED [EC:2.4.2.26]
synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26]
synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26]
synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26]
synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" RELATED [EC:2.4.2.26]
synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" RELATED [EC:2.4.2.26]
xref: EC:2.4.2.26
xref: MetaCyc:2.4.2.26-RXN
xref: Reactome:R-HSA-1878002 "XYLTs transfer Xyl to core protein"
xref: RHEA:50192
is_a: GO:0035252 ! UDP-xylosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0030159
name: signaling receptor complex adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]
synonym: "receptor signaling complex adaptor activity" EXACT []
synonym: "receptor signaling complex scaffold activity" EXACT []
synonym: "receptor signaling complex scaffold protein activity" EXACT []
synonym: "receptor signalling complex adaptor activity" EXACT []
synonym: "receptor signalling complex scaffold activity" EXACT []
is_a: GO:0035591 ! signaling adaptor activity

[Term]
id: GO:0030160
name: synaptic receptor adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule." [PMID:10506216]
synonym: "GKAP/Homer scaffold activity" NARROW []
synonym: "GKAP/Homer scaffold protein" NARROW []
synonym: "postsynaptic density scaffold protein" NARROW []
is_a: GO:0030159 ! signaling receptor complex adaptor activity

[Term]
id: GO:0030161
name: obsolete calpain inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of a non-existent molecular function.
synonym: "calpain inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0010859

[Term]
id: GO:0030162
name: regulation of proteolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
synonym: "regulation of peptidolysis" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0006508 ! proteolysis

[Term]
id: GO:0030163
name: protein catabolic process
namespace: biological_process
alt_id: GO:0044254
alt_id: GO:0044257
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular protein breakdown" EXACT []
synonym: "cellular protein catabolic process" EXACT []
synonym: "cellular protein catabolism" EXACT []
synonym: "cellular protein degradation" EXACT []
synonym: "multicellular organismal protein catabolic process" NARROW []
synonym: "pheromone catabolic process" RELATED []
synonym: "pheromone catabolism" RELATED []
synonym: "protein breakdown" EXACT []
synonym: "protein catabolism" EXACT []
synonym: "protein degradation" EXACT []
xref: Wikipedia:Protein_catabolism
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0030164
name: protein denaturation
namespace: biological_process
def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359]
xref: Wikipedia:Denaturation#Protein_denaturation
is_a: GO:0030163 ! protein catabolic process

[Term]
id: GO:0030165
name: PDZ domain binding
namespace: molecular_function
def: "Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]
synonym: "DHR-domain binding" EXACT []
synonym: "GLGF-domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030166
name: proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
synonym: "proteoglycan anabolism" EXACT []
synonym: "proteoglycan biosynthesis" EXACT []
synonym: "proteoglycan formation" EXACT []
synonym: "proteoglycan synthesis" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0030167
name: proteoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
synonym: "proteoglycan breakdown" EXACT []
synonym: "proteoglycan catabolism" EXACT []
synonym: "proteoglycan degradation" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006516 ! glycoprotein catabolic process

[Term]
id: GO:0030168
name: platelet activation
namespace: biological_process
def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [PMID:27403440]
synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0007596 ! blood coagulation

[Term]
id: GO:0030169
name: low-density lipoprotein particle binding
namespace: molecular_function
def: "Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah]
subset: goslim_chembl
synonym: "LDL binding" EXACT []
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0030170
name: pyridoxal phosphate binding
namespace: molecular_function
def: "Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
subset: goslim_metagenomics
is_a: GO:0043168 ! anion binding
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0030171
name: voltage-gated proton channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:28774948]
synonym: "voltage gated proton channel activity" EXACT []
synonym: "voltage-dependent proton channel activity" EXACT []
is_a: GO:0015252 ! proton channel activity
is_a: GO:0022843 ! voltage-gated monoatomic cation channel activity

[Term]
id: GO:0030172
name: troponin C binding
namespace: molecular_function
def: "Binding to troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030173
name: obsolete integral component of Golgi membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "Golgi integral membrane protein" RELATED []
synonym: "integral to Golgi membrane" NARROW []
is_obsolete: true
replaced_by: GO:0000139

[Term]
id: GO:0030174
name: regulation of DNA-templated DNA replication initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah]
synonym: "DNA replication licencing" EXACT []
synonym: "DNA replication licensing" EXACT []
synonym: "regulation of DNA replication initiation" BROAD [GOC:vw]
synonym: "regulation of DNA-dependent DNA replication initiation" EXACT []
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
relationship: regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0030175
name: filopodium
namespace: cellular_component
alt_id: GO:0030028
def: "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]
comment: A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473.
subset: goslim_pir
xref: NIF_Subcellular:sao1046371754
xref: Wikipedia:Filopodia
is_a: GO:0098858 ! actin-based cell projection

[Term]
id: GO:0030176
name: obsolete integral component of endoplasmic reticulum membrane
namespace: cellular_component
def: "OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "ER integral membrane protein" EXACT []
synonym: "integral to endoplasmic reticulum membrane" NARROW []
synonym: "integral to ER membrane" EXACT []
is_obsolete: true
replaced_by: GO:0005789

[Term]
id: GO:0030177
name: positive regulation of Wnt signaling pathway
namespace: biological_process
alt_id: GO:0045811
def: "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of frizzled signaling pathway" NARROW []
synonym: "activation of Wnt receptor signaling pathway" NARROW []
synonym: "positive regulation of frizzled signaling pathway" EXACT []
synonym: "positive regulation of frizzled signalling pathway" EXACT []
synonym: "positive regulation of Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway" EXACT []
synonym: "positive regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "stimulation of frizzled signaling pathway" NARROW []
synonym: "stimulation of Wnt receptor signaling pathway" NARROW []
synonym: "up regulation of frizzled signaling pathway" EXACT []
synonym: "up regulation of Wnt receptor signaling pathway" EXACT []
synonym: "up-regulation of frizzled signaling pathway" EXACT []
synonym: "up-regulation of Wnt receptor signaling pathway" EXACT []
synonym: "upregulation of frizzled signaling pathway" EXACT []
synonym: "upregulation of Wnt receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0030111 ! regulation of Wnt signaling pathway
relationship: positively_regulates GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0030178
name: negative regulation of Wnt signaling pathway
namespace: biological_process
alt_id: GO:0045810
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of frizzled signaling pathway" EXACT []
synonym: "down regulation of Wnt receptor signaling pathway" EXACT []
synonym: "down-regulation of frizzled signaling pathway" EXACT []
synonym: "down-regulation of Wnt receptor signaling pathway" EXACT []
synonym: "downregulation of frizzled signaling pathway" EXACT []
synonym: "downregulation of Wnt receptor signaling pathway" EXACT []
synonym: "inhibition of frizzled signaling pathway" NARROW []
synonym: "inhibition of Wnt receptor signaling pathway" NARROW []
synonym: "negative regulation of frizzled signaling pathway" EXACT []
synonym: "negative regulation of frizzled signalling pathway" EXACT []
synonym: "negative regulation of Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway" EXACT []
synonym: "negative regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0030111 ! regulation of Wnt signaling pathway
relationship: negatively_regulates GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0030180
name: obsolete solute:solute exchange
namespace: biological_process
def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah]
comment: This term was made obsolete because it represents a molecular function.
synonym: "solute:solute exchange" EXACT []
is_obsolete: true
consider: GO:0006810
consider: GO:0015297

[Term]
id: GO:0030181
name: obsolete sodium:calcium exchange
namespace: biological_process
def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "sodium:calcium exchange" EXACT []
is_obsolete: true
consider: GO:0005432
consider: GO:0006814
consider: GO:0006816

[Term]
id: GO:0030182
name: neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0030183
name: B cell differentiation
namespace: biological_process
alt_id: GO:0042115
def: "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B cell development" RELATED [GOC:add]
synonym: "B lymphocyte differentiation" EXACT []
synonym: "B-cell differentiation" EXACT []
synonym: "B-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0030184
name: nitric oxide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah]
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity

[Term]
id: GO:0030185
name: nitric oxide transport
namespace: biological_process
def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0030186
name: melatonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
synonym: "melatonin metabolism" EXACT []
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0030187
name: melatonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
synonym: "melatonin anabolism" EXACT []
synonym: "melatonin biosynthesis" EXACT []
synonym: "melatonin formation" EXACT []
synonym: "melatonin synthesis" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0030188
name: obsolete chaperone regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
synonym: "chaperone regulator activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030189
name: obsolete chaperone activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
synonym: "chaperone activator activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030190
name: obsolete chaperone inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
synonym: "chaperone inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030191
name: obsolete Hsp70/Hsc70 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
synonym: "Hsp70/Hsc70 protein inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030192
name: obsolete Hsp70/Hsc70 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
synonym: "Hsp70/Hsc70 protein regulator activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030193
name: regulation of blood coagulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0061041 ! regulation of wound healing
is_a: GO:1900046 ! regulation of hemostasis
relationship: regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030194
name: positive regulation of blood coagulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah]
synonym: "activation of blood coagulation" NARROW []
synonym: "stimulation of blood coagulation" NARROW []
synonym: "up regulation of blood coagulation" EXACT []
synonym: "up-regulation of blood coagulation" EXACT []
synonym: "upregulation of blood coagulation" EXACT []
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050820 ! positive regulation of coagulation
is_a: GO:0090303 ! positive regulation of wound healing
is_a: GO:1900048 ! positive regulation of hemostasis
relationship: positively_regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030195
name: negative regulation of blood coagulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah]
synonym: "down regulation of blood coagulation" EXACT []
synonym: "down-regulation of blood coagulation" EXACT []
synonym: "downregulation of blood coagulation" EXACT []
synonym: "inhibition of blood coagulation" NARROW []
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050819 ! negative regulation of coagulation
is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1900047 ! negative regulation of hemostasis
relationship: negatively_regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030196
name: cyanide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: formamide = H2O + hydrogen cyanide." [EC:4.2.1.66, RHEA:21720]
synonym: "formamide dehydratase activity" RELATED [EC:4.2.1.66]
synonym: "formamide hydro-lyase (cyanide-forming)" RELATED [EC:4.2.1.66]
synonym: "formamide hydro-lyase activity" RELATED [EC:4.2.1.66]
xref: EC:4.2.1.66
xref: KEGG_REACTION:R01408
xref: MetaCyc:CYANIDE-HYDRATASE-RXN
xref: RHEA:21720
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0030197
name: extracellular matrix constituent, lubricant activity
namespace: molecular_function
def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah]
comment: Extracellular matrix mucin proteins may be annotated to this term. PMID:14711375, PMID:18601586
synonym: "core extracellular matrix" BROAD []
synonym: "core matrisome" BROAD []
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030198
name: extracellular matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
synonym: "extracellular matrix organisation" EXACT []
synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0030199
name: collagen fibril organization
namespace: biological_process
def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]
synonym: "collagen fibril organisation" EXACT []
synonym: "fibrillar collagen organization" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0030200
name: heparan sulfate proteoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]
synonym: "heparan sulfate proteoglycan breakdown" EXACT []
synonym: "heparan sulfate proteoglycan catabolism" EXACT []
synonym: "heparan sulfate proteoglycan degradation" EXACT []
synonym: "heparan sulphate proteoglycan catabolic process" EXACT []
synonym: "heparan sulphate proteoglycan catabolism" EXACT []
synonym: "heparin proteoglycan catabolic process" RELATED []
is_a: GO:0030167 ! proteoglycan catabolic process
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0030201
name: heparan sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]
synonym: "heparan sulfate proteoglycan metabolism" EXACT []
synonym: "heparan sulphate proteoglycan metabolic process" EXACT []
synonym: "heparan sulphate proteoglycan metabolism" EXACT []
synonym: "heparin proteoglycan metabolic process" RELATED []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0030202
name: heparin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
synonym: "heparan sulfate metabolic process" RELATED []
synonym: "heparin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process

[Term]
id: GO:0030203
name: glycosaminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
synonym: "glycosaminoglycan metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0030204
name: chondroitin sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732]
synonym: "chondroitin sulfate metabolism" EXACT []
synonym: "chondroitin sulphate metabolic process" EXACT []
synonym: "chondroitin sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process
relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process

[Term]
id: GO:0030205
name: dermatan sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732]
synonym: "chondroitin sulfate B metabolic process" EXACT []
synonym: "chondroitin sulfate B metabolism" EXACT []
synonym: "dermatan sulfate metabolism" EXACT []
synonym: "dermatan sulphate metabolic process" EXACT []
synonym: "dermatan sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process
relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process

[Term]
id: GO:0030206
name: chondroitin sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]
synonym: "chondroitin sulfate anabolism" EXACT []
synonym: "chondroitin sulfate biosynthesis" EXACT []
synonym: "chondroitin sulfate formation" EXACT []
synonym: "chondroitin sulfate synthesis" EXACT []
synonym: "chondroitin sulphate biosynthesis" EXACT []
synonym: "chondroitin sulphate biosynthetic process" EXACT []
xref: MetaCyc:PWY-6567
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030204 ! chondroitin sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process

[Term]
id: GO:0030207
name: chondroitin sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]
synonym: "chondroitin sulfate breakdown" EXACT []
synonym: "chondroitin sulfate catabolism" EXACT []
synonym: "chondroitin sulfate degradation" EXACT []
synonym: "chondroitin sulphate catabolic process" EXACT []
synonym: "chondroitin sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030204 ! chondroitin sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0030208
name: dermatan sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732]
synonym: "chondroitin sulfate B biosynthesis" EXACT []
synonym: "chondroitin sulfate B biosynthetic process" EXACT []
synonym: "dermatan sulfate anabolism" EXACT []
synonym: "dermatan sulfate biosynthesis" EXACT []
synonym: "dermatan sulfate formation" EXACT []
synonym: "dermatan sulfate synthesis" EXACT []
synonym: "dermatan sulphate biosynthesis" EXACT []
synonym: "dermatan sulphate biosynthetic process" EXACT []
xref: MetaCyc:PWY-6568
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030205 ! dermatan sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0030209
name: dermatan sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732]
synonym: "chondroitin sulfate B catabolic process" EXACT []
synonym: "chondroitin sulfate B catabolism" EXACT []
synonym: "dermatan sulfate breakdown" EXACT []
synonym: "dermatan sulfate catabolism" EXACT []
synonym: "dermatan sulfate degradation" EXACT []
synonym: "dermatan sulphate catabolic process" EXACT []
synonym: "dermatan sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030205 ! dermatan sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0030210
name: heparin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
synonym: "heparan sulfate biosynthetic process" RELATED []
synonym: "heparin anabolism" EXACT []
synonym: "heparin biosynthesis" EXACT []
synonym: "heparin formation" EXACT []
synonym: "heparin synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030202 ! heparin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0030211
name: heparin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
synonym: "heparan sulfate catabolic process" RELATED []
synonym: "heparin breakdown" EXACT []
synonym: "heparin catabolism" EXACT []
synonym: "heparin degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030202 ! heparin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0030212
name: hyaluronan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
synonym: "hyaluronan metabolism" EXACT []
is_a: GO:1903510 ! mucopolysaccharide metabolic process

[Term]
id: GO:0030213
name: hyaluronan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
synonym: "hyaluronan anabolism" EXACT []
synonym: "hyaluronan biosynthesis" EXACT []
synonym: "hyaluronan formation" EXACT []
synonym: "hyaluronan synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030212 ! hyaluronan metabolic process

[Term]
id: GO:0030214
name: hyaluronan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
synonym: "hyaluronan breakdown" EXACT []
synonym: "hyaluronan catabolism" EXACT []
synonym: "hyaluronan degradation" EXACT []
xref: MetaCyc:PWY-7645
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030212 ! hyaluronan metabolic process

[Term]
id: GO:0030215
name: semaphorin receptor binding
namespace: molecular_function
def: "Binding to a semaphorin receptor." [GOC:ceb, PMID:12001990]
synonym: "plexin binding" NARROW []
synonym: "plexin ligand" NARROW []
synonym: "semaphorin receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0030216
name: keratinocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]
synonym: "keratinocyte cell differentiation" EXACT []
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0030217
name: T cell differentiation
namespace: biological_process
alt_id: GO:0042112
alt_id: GO:0046652
def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah]
comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development" RELATED [GOC:add]
synonym: "T lymphocyte differentiation" EXACT []
synonym: "T-cell differentiation" EXACT []
synonym: "T-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0030218
name: erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah]
synonym: "erythrocyte cell differentiation" EXACT []
synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph]
synonym: "RBC differentiation" EXACT [CL:0000232]
synonym: "red blood cell differentiation" EXACT [CL:0000232]
xref: Wikipedia:Erythropoiesis
is_a: GO:0030099 ! myeloid cell differentiation
relationship: part_of GO:0034101 ! erythrocyte homeostasis

[Term]
id: GO:0030219
name: megakaryocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah]
synonym: "megakaryocyte cell differentiation" EXACT []
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0030220
name: platelet formation
namespace: biological_process
def: "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194]
synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators]
is_a: GO:0030099 ! myeloid cell differentiation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0036344 ! platelet morphogenesis

[Term]
id: GO:0030221
name: basophil differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah]
synonym: "basophil cell differentiation" EXACT []
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030222
name: eosinophil differentiation
namespace: biological_process
alt_id: GO:0035856
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:add, GOC:mah]
synonym: "eosinophil cell development" RELATED [GOC:bf]
synonym: "eosinophil cell differentiation" EXACT []
synonym: "eosinophil development" RELATED []
is_a: GO:0030851 ! granulocyte differentiation
is_a: GO:0048468 ! cell development

[Term]
id: GO:0030223
name: neutrophil differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah]
synonym: "neutrophil cell differentiation" EXACT []
synonym: "neutrophil granulocyte differentiation" EXACT [GOC:yaf]
synonym: "neutrophil granulocytopoiesis" EXACT [GOC:yaf]
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030224
name: monocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah]
synonym: "monocyte cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:1903131 ! mononuclear cell differentiation

[Term]
id: GO:0030225
name: macrophage differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149]
synonym: "macrophage cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:1903131 ! mononuclear cell differentiation

[Term]
id: GO:0030226
name: apolipoprotein receptor activity
namespace: molecular_function
def: "Combining with an apolipoprotein to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0030227
name: obsolete apolipoprotein E receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah]
comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
synonym: "ApoE receptor" EXACT []
synonym: "apolipoprotein E receptor activity" EXACT []
is_obsolete: true
replaced_by: GO:0030229

[Term]
id: GO:0030228
name: lipoprotein particle receptor activity
namespace: molecular_function
def: "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:bf, GOC:mah, PMID:12827279]
comment: This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'.
synonym: "lipoprotein receptor activity" EXACT [GOC:dph]
synonym: "plasma lipoprotein particle receptor activity" NARROW [GOC:BHF]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0030229
name: very-low-density lipoprotein particle receptor activity
namespace: molecular_function
def: "Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732]
synonym: "apolipoprotein E receptor activity" RELATED [GOC:rl]
synonym: "very-low-density lipoprotein receptor activity" EXACT [GOC:dph]
synonym: "VLDL receptor" EXACT []
xref: Wikipedia:VLDL_receptor
is_a: GO:0030228 ! lipoprotein particle receptor activity

[Term]
id: GO:0030232
name: insulin control element activator complex
namespace: cellular_component
def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390]
synonym: "ICE activator complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0030233
name: deoxynucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0030234
name: enzyme regulator activity
namespace: molecular_function
alt_id: GO:0010576
def: "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]
comment: This term should only be used in cases when the regulator directly interacts with the enzyme.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "catalytic regulator activity" EXACT [GOC:dph]
synonym: "enzyme modulator" EXACT []
synonym: "metalloenzyme regulator activity" NARROW []
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0030235
name: nitric-oxide synthase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah]
comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'.
synonym: "nitric oxide synthase regulator activity" EXACT []
xref: Reactome:R-HSA-202129 "HSP90 binds eNOS:Caveolin-1:CaM complex"
xref: Reactome:R-HSA-202144 "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex"
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0030237
name: female sex determination
namespace: biological_process
def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0030238
name: male sex determination
namespace: biological_process
def: "The specification of male sex of an individual organism." [GOC:mah]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0030239
name: myofibril assembly
namespace: biological_process
def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0031032 ! actomyosin structure organization
is_a: GO:0097435 ! supramolecular fiber organization
is_a: GO:0140694 ! membraneless organelle assembly
relationship: part_of GO:0055002 ! striated muscle cell development

[Term]
id: GO:0030240
name: skeletal muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0014866 ! skeletal myofibril assembly

[Term]
id: GO:0030241
name: skeletal muscle myosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
is_a: GO:0071688 ! striated muscle myosin thick filament assembly
relationship: part_of GO:0014866 ! skeletal myofibril assembly

[Term]
id: GO:0030242
name: autophagy of peroxisome
namespace: biological_process
def: "The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110]
subset: gocheck_do_not_annotate
synonym: "peroxisome degradation" BROAD []
synonym: "peroxisome disassembly" BROAD []
synonym: "pexophagy" RELATED []
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0030243
name: cellulose metabolic process
namespace: biological_process
alt_id: GO:0016177
def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]
synonym: "cellulose metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0030244
name: cellulose biosynthetic process
namespace: biological_process
alt_id: GO:0016178
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]
synonym: "cellulose anabolism" EXACT []
synonym: "cellulose biosynthesis" EXACT []
synonym: "cellulose formation" EXACT []
synonym: "cellulose synthesis" EXACT []
xref: MetaCyc:PWY-1001
is_a: GO:0030243 ! cellulose metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0030245
name: cellulose catabolic process
namespace: biological_process
alt_id: GO:0016179
def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]
synonym: "cellulose breakdown" EXACT []
synonym: "cellulose catabolism" EXACT []
synonym: "cellulose degradation" EXACT []
is_a: GO:0030243 ! cellulose metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0030246
name: carbohydrate binding
namespace: molecular_function
alt_id: GO:0005529
def: "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "selectin" RELATED []
synonym: "sugar binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0030247
name: polysaccharide binding
namespace: molecular_function
alt_id: GO:0002506
def: "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]
synonym: "polysaccharide assembly with MHC class II protein complex" NARROW []
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0030248
name: cellulose binding
namespace: molecular_function
def: "Binding to cellulose." [GOC:mah]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0030249
name: guanylate cyclase regulator activity
namespace: molecular_function
def: "Modulates the activity of guanylate cyclase." [GOC:mah]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0030250
name: guanylate cyclase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of guanylate cyclase." [GOC:mah]
synonym: "guanylin" NARROW []
is_a: GO:0010853 ! cyclase activator activity
is_a: GO:0030249 ! guanylate cyclase regulator activity

[Term]
id: GO:0030251
name: guanylate cyclase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah]
is_a: GO:0010852 ! cyclase inhibitor activity
is_a: GO:0030249 ! guanylate cyclase regulator activity

[Term]
id: GO:0030252
name: growth hormone secretion
namespace: biological_process
def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah]
synonym: "somatotropin secretion" EXACT [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030253
name: protein secretion by the type I secretion system
namespace: biological_process
def: "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'.
synonym: "protein secretion by the TOSS" EXACT []
synonym: "protein secretion by the type I protein secretion system" EXACT []
synonym: "type I protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0030254
name: protein secretion by the type III secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted.
synonym: "protein secretion by the T3S" EXACT []
synonym: "protein secretion by the T3SS" EXACT []
synonym: "protein secretion by the TTSS" EXACT []
synonym: "protein secretion by the type III protein secretion system" EXACT []
synonym: "type III protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0030255
name: protein secretion by the type IV secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'.
synonym: "protein secretion by the T4SS" EXACT []
synonym: "protein secretion by the type IV protein secretion system" EXACT []
synonym: "type IV protein secretion system" NARROW []
is_a: GO:0009306 ! protein secretion
is_a: GO:0044097 ! secretion by the type IV secretion system
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0030256
name: type I protein secretion system complex
namespace: cellular_component
def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447]
synonym: "ABC translocator complex" BROAD []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0030257
name: type III protein secretion system complex
namespace: cellular_component
def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447]
synonym: "T3SS complex" EXACT []
synonym: "TTSS complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0030258
name: lipid modification
namespace: biological_process
def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0030259
name: lipid glycosylation
namespace: biological_process
def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0030258 ! lipid modification
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0030261
name: chromosome condensation
namespace: biological_process
alt_id: GO:0000068
def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation]
synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf]
synonym: "nuclear chromosome condensation" EXACT [GOC:bf]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0030262
name: apoptotic nuclear changes
namespace: biological_process
def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptotic nuclear change" NARROW []
is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis

[Term]
id: GO:0030263
name: apoptotic chromosome condensation
namespace: biological_process
def: "The compaction of chromatin during apoptosis." [GOC:mah]
synonym: "pyknosis" EXACT []
xref: Wikipedia:Pyknosis
is_a: GO:0030261 ! chromosome condensation
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030264
name: nuclear fragmentation involved in apoptotic nuclear change
namespace: biological_process
def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976]
synonym: "apoptotic nuclear fragmentation" EXACT []
synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb]
synonym: "nucleus fragmentation" EXACT []
is_a: GO:0071763 ! nuclear membrane organization
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030265
name: phospholipase C-activating opsin-mediated signaling pathway
namespace: biological_process
def: "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and transmitting the signal through the Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). The second messengers, including cGMP, activate channels that result in transmission of the light signal  through the synapses. Typical examples are rhabdomeric photoreceptors in the eyes of protostomes." [PMID:19720651, PMID:22498302, PMID:8823931]
synonym: "phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway" NARROW [GOC:bf]
synonym: "phospholipase C-activating rhodopsin mediated signaling pathway" NARROW []
synonym: "PLC-activating rhodopsin mediated signaling pathway" NARROW [GOC:bf]
synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" NARROW []
synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" NARROW []
synonym: "rhodopsin mediated G-protein signaling, coupled to IP3 second messenger" NARROW [GOC:signaling]
synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" NARROW []
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0016056 ! G protein-coupled opsin signaling pathway

[Term]
id: GO:0030266
name: quinate 3-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+." [EC:1.1.1.24]
synonym: "quinate:NAD 3-oxidoreductase activity" EXACT []
synonym: "quinate:NAD 5-oxidoreductase activity" RELATED [EC:1.1.1.24]
synonym: "quinate:NAD(+) 3-oxidoreductase activity" EXACT []
synonym: "quinate:NAD(+) 5-oxidoreductase activity" RELATED [EC:1.1.1.24]
synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24]
xref: EC:1.1.1.24
xref: KEGG_REACTION:R01872
xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN
xref: RHEA:22364
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030267
name: glyoxylate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [RHEA:10992]
synonym: "glycolate:NADP+ oxidoreductase activity" RELATED []
synonym: "glyoxylate reductase (NADP+)" RELATED [EC:1.1.1.79]
synonym: "NADPH-glyoxylate reductase activity" RELATED []
xref: EC:1.1.1.79
xref: MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN
xref: Reactome:R-HSA-389826 "glyoxylate + NADPH + H+ => glycolate + NADP+"
xref: RHEA:10992
xref: Wikipedia:Glyoxylate_reductase_(NADP+)
is_a: GO:0106345 ! glyoxylate reductase activity

[Term]
id: GO:0030268
name: methylenetetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0018536
def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H+ = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.98.1, RHEA:16721]
synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.5.98.1]
synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.1]
synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.5.98.1]
xref: EC:1.5.98.1
xref: KEGG_REACTION:R04456
xref: MetaCyc:1.5.99.9-RXN
xref: RHEA:16721
xref: UM-BBD_reactionID:r0348
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0030269
name: tetrahydromethanopterin S-methyltransferase activity
namespace: molecular_function
alt_id: GO:0018709
def: "Catalysis of the reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na+(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na+(out). 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [RHEA:53492]
synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" RELATED [EC:7.2.1.4]
synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" RELATED [EC:7.2.1.4]
synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" RELATED [EC:7.2.1.4]
synonym: "tetrahydromethanopterin methyltransferase activity" RELATED [EC:7.2.1.4]
xref: EC:7.2.1.4
xref: KEGG_REACTION:R04347
xref: MetaCyc:2.1.1.86-RXN
xref: RHEA:53492
xref: UM-BBD_reactionID:r0355
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity

[Term]
id: GO:0030270
name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity
namespace: molecular_function
alt_id: GO:0018714
def: "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran." [EC:2.3.1.101, RHEA:18061]
synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" RELATED [EC:2.3.1.101]
synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" RELATED [EC:2.3.1.101]
synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" RELATED [EC:2.3.1.101]
synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" RELATED [EC:2.3.1.101]
synonym: "FTR" RELATED [EC:2.3.1.101]
synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" RELATED [EC:2.3.1.101]
xref: EC:2.3.1.101
xref: KEGG_REACTION:R03390
xref: MetaCyc:2.3.1.101-RXN
xref: RHEA:18061
xref: UM-BBD_reactionID:r0346
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0030271
name: obsolete chymase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "chymase activity" EXACT []
synonym: "mast cell protease I activity" NARROW []
synonym: "mast cell serine proteinase" NARROW []
synonym: "SK protease activity" RELATED []
synonym: "skeletal muscle (SK) protease activity" NARROW []
synonym: "skeletal muscle protease" NARROW []
synonym: "skin chymotryptic proteinase" NARROW []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030272
name: 5-formyltetrahydrofolate cyclo-ligase activity
namespace: molecular_function
alt_id: GO:0019006
def: "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate." [EC:6.3.3.2, RHEA:10488]
synonym: "5,10-methenyltetrahydrofolate synthetase activity" RELATED [EC:6.3.3.2]
synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.2]
synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2]
synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" RELATED [EC:6.3.3.2]
synonym: "formyltetrahydrofolic cyclodehydrase activity" RELATED [EC:6.3.3.2]
synonym: "methenyl-THF synthetase activity" RELATED [EC:6.3.3.2]
xref: EC:6.3.3.2
xref: KEGG_REACTION:R02301
xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN
xref: Reactome:R-HSA-6801342 "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG"
xref: RHEA:10488
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0030273
name: melanin-concentrating hormone receptor activity
namespace: molecular_function
def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "MCH receptor" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0030274
name: LIM domain binding
namespace: molecular_function
def: "Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030275
name: LRR domain binding
namespace: molecular_function
def: "Binding to a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030276
name: clathrin binding
namespace: molecular_function
def: "Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030277
name: maintenance of gastrointestinal epithelium
namespace: biological_process
def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah]
is_a: GO:0010669 ! epithelial structure maintenance
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0030278
name: regulation of ossification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "regulation of bone biosynthesis" EXACT []
synonym: "regulation of bone formation" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001503 ! ossification

[Term]
id: GO:0030279
name: negative regulation of ossification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "down regulation of ossification" EXACT []
synonym: "down-regulation of ossification" EXACT []
synonym: "downregulation of ossification" EXACT []
synonym: "inhibition of ossification" NARROW []
synonym: "negative regulation of bone biosynthesis" EXACT []
synonym: "negative regulation of bone formation" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0001503 ! ossification

[Term]
id: GO:0030280
name: structural constituent of skin epidermis
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah]
synonym: "structural constituent of epidermis" BROAD []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0030281
name: structural constituent of cutaneous appendage
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0030282
name: bone mineralization
namespace: biological_process
def: "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." [GOC:mah, PMID:22936354]
synonym: "bone calcification" NARROW []
is_a: GO:0031214 ! biomineral tissue development
relationship: part_of GO:0001503 ! ossification

[Term]
id: GO:0030283
name: testosterone dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51]
synonym: "17beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51]
synonym: "3(or 17)beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.51]
synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" BROAD [EC:1.1.1.51]
synonym: "3beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51]
synonym: "3beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.51]
synonym: "beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51]
xref: EC:1.1.1.51
xref: MetaCyc:1.1.1.51-RXN
xref: Reactome:R-HSA-193064 "HSD17B3-like proteins reducde ANDST to TEST"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030284
name: nuclear estrogen receptor activity
namespace: molecular_function
def: "A nuclear receptor activity regulated by estrogen binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:signaling, PMID:17615392]
synonym: "estrogen receptor activity" BROAD []
is_a: GO:0003707 ! nuclear steroid receptor activity

[Term]
id: GO:0030285
name: obsolete integral component of synaptic vesicle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to synaptic vesicle membrane" NARROW []
is_obsolete: true
replaced_by: GO:0030672

[Term]
id: GO:0030286
name: dynein complex
namespace: cellular_component
def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0030287
name: cell wall-bounded periplasmic space
namespace: cellular_component
def: "The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu]
synonym: "cell wall bounded periplasmic space" EXACT []
synonym: "cell wall-enclosed periplasmic space" EXACT []
synonym: "inner wall zone" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space]
synonym: "IWZ" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space]
is_a: GO:0042597 ! periplasmic space

[Term]
id: GO:0030288
name: outer membrane-bounded periplasmic space
namespace: cellular_component
def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall." [GOC:mlg, GOC:mtg_sensu]
synonym: "outer membrane bounded periplasmic space" EXACT []
synonym: "outer membrane-enclosed periplasmic space" EXACT []
xref: Wikipedia:Periplasmic_space
is_a: GO:0042597 ! periplasmic space
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0030289
name: protein phosphatase 4 complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bhm, PMID:10026142]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex

[Term]
id: GO:0030290
name: sphingolipid activator protein activity
namespace: molecular_function
def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732]
synonym: "saposin" NARROW []
xref: Reactome:R-HSA-1605717 "GM2A binds and mobilizes ligands"
xref: Reactome:R-HSA-9840470 "PSAP(195-273) dimer:PE binds and mobilizes ligands"
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0030291
name: protein serine/threonine kinase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity

[Term]
id: GO:0030292
name: protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity

[Term]
id: GO:0030293
name: transmembrane receptor protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]
is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity
is_a: GO:0030547 ! signaling receptor inhibitor activity

[Term]
id: GO:0030294
name: receptor signaling protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah]
synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT []
is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity

[Term]
id: GO:0030295
name: protein kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
is_a: GO:0019209 ! kinase activator activity
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0030296
name: protein tyrosine kinase activator activity
namespace: molecular_function
def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732]
is_a: GO:0030295 ! protein kinase activator activity

[Term]
id: GO:0030297
name: transmembrane receptor protein tyrosine kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]
is_a: GO:0030296 ! protein tyrosine kinase activator activity
is_a: GO:0030546 ! signaling receptor activator activity

[Term]
id: GO:0030298
name: receptor signaling protein tyrosine kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a receptor signaling protein tyrosine kinase." [GOC:mah]
synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT []
is_a: GO:0030296 ! protein tyrosine kinase activator activity

[Term]
id: GO:0030299
name: intestinal cholesterol absorption
namespace: biological_process
def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah]
is_a: GO:0098856 ! intestinal lipid absorption
relationship: part_of GO:0044241 ! lipid digestion

[Term]
id: GO:0030300
name: regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417]
is_a: GO:1904729 ! regulation of intestinal lipid absorption
relationship: regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0030301
name: cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]
is_a: GO:0015918 ! sterol transport

[Term]
id: GO:0030302
name: deoxynucleotide transport
namespace: biological_process
def: "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732]
is_a: GO:0006862 ! nucleotide transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0030303
name: obsolete stromelysin 2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 10 activity" RELATED []
synonym: "MMP-10" EXACT []
synonym: "proteoglycanase 2" RELATED []
synonym: "stromelysin 2 activity" EXACT []
synonym: "transin 2 activity" RELATED []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030304
name: obsolete trypsin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "trypsin inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030305
name: heparanase activity
namespace: molecular_function
def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150]
synonym: "heparinase activity" RELATED []
xref: Reactome:R-HSA-1667005 "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0030307
name: positive regulation of cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
synonym: "activation of cell growth" NARROW []
synonym: "stimulation of cell growth" NARROW []
synonym: "up regulation of cell growth" EXACT []
synonym: "up-regulation of cell growth" EXACT []
synonym: "upregulation of cell growth" EXACT []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0016049 ! cell growth

[Term]
id: GO:0030308
name: negative regulation of cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
synonym: "down regulation of cell growth" EXACT []
synonym: "down-regulation of cell growth" EXACT []
synonym: "downregulation of cell growth" EXACT []
synonym: "inhibition of cell growth" NARROW []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0016049 ! cell growth

[Term]
id: GO:0030309
name: poly-N-acetyllactosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
synonym: "poly-N-acetyllactosamine metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0030310
name: poly-N-acetyllactosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
synonym: "poly-N-acetyllactosamine breakdown" EXACT []
synonym: "poly-N-acetyllactosamine catabolism" EXACT []
synonym: "poly-N-acetyllactosamine degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process

[Term]
id: GO:0030311
name: poly-N-acetyllactosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
synonym: "poly-N-acetyllactosamine anabolism" EXACT []
synonym: "poly-N-acetyllactosamine biosynthesis" EXACT []
synonym: "poly-N-acetyllactosamine formation" EXACT []
synonym: "poly-N-acetyllactosamine synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process

[Term]
id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators]
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0030313
name: cell envelope
namespace: cellular_component
def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm]
subset: goslim_pir
xref: Wikipedia:Cell_envelope
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0030314
name: junctional membrane complex
namespace: cellular_component
def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]
synonym: "triad junction" BROAD []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0030315
name: T-tubule
namespace: cellular_component
def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194]
synonym: "transverse tubule" EXACT []
synonym: "triad" RELATED []
xref: Wikipedia:T-tubule
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042383 ! sarcolemma

[Term]
id: GO:0030316
name: osteoclast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]
synonym: "osteoclast cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030317
name: flagellated sperm motility
namespace: biological_process
alt_id: GO:0097724
alt_id: GO:1905419
def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]
synonym: "flagellated sperm movement" EXACT []
synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc]
synonym: "sperm flagellum movement involved in flagellated sperm motility" EXACT []
synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie]
synonym: "sperm motility" BROAD []
synonym: "sperm movement" BROAD []
xref: Wikipedia:Sperm_motility
is_a: GO:0060285 ! cilium-dependent cell motility
is_a: GO:0060294 ! cilium movement involved in cell motility
is_a: GO:0097722 ! sperm motility

[Term]
id: GO:0030318
name: melanocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah]
synonym: "melanocyte cell differentiation" EXACT []
synonym: "melanophore differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0030319
name: obsolete cellular di-, tri-valent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]
comment: This term was made obsolete because it has been split.
synonym: "cellular di-, tri-valent inorganic anion homeostasis" EXACT []
is_obsolete: true
consider: GO:0030002

[Term]
id: GO:0030320
name: obsolete cellular monovalent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0030002

[Term]
id: GO:0030321
name: transepithelial chloride transport
namespace: biological_process
def: "The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah]
is_a: GO:0006821 ! chloride transport
is_a: GO:0070633 ! transepithelial transport

[Term]
id: GO:0030322
name: stabilization of membrane potential
namespace: biological_process
def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0030323
name: respiratory tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid]
is_a: GO:0035295 ! tube development
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0030324
name: lung development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0030323 ! respiratory tube development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0030325
name: adrenal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh]
synonym: "interrenal gland" RELATED []
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0030326
name: embryonic limb morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172]
is_a: GO:0035108 ! limb morphogenesis
is_a: GO:0035113 ! embryonic appendage morphogenesis

[Term]
id: GO:0030327
name: prenylated protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah]
synonym: "prenylated protein breakdown" EXACT []
synonym: "prenylated protein catabolism" EXACT []
synonym: "prenylated protein degradation" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0030328
name: prenylcysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]
synonym: "prenylcysteine breakdown" EXACT []
synonym: "prenylcysteine catabolism" EXACT []
synonym: "prenylcysteine degradation" EXACT []
is_a: GO:0030329 ! prenylcysteine metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process

[Term]
id: GO:0030329
name: prenylcysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, PMID:16627894]
synonym: "prenylcysteine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process

[Term]
id: GO:0030330
name: DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
alt_id: GO:0006976
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]
synonym: "DNA damage response, activation of p53" RELATED []
synonym: "p53 signaling pathway" RELATED [GOC:mah, GOC:vk]
synonym: "p53-mediated DNA damage response" BROAD []
synonym: "TP53 signaling pathway" RELATED [GOC:mah, GOC:vk]
is_a: GO:0042770 ! signal transduction in response to DNA damage
is_a: GO:0072331 ! signal transduction by p53 class mediator

[Term]
id: GO:0030331
name: nuclear estrogen receptor binding
namespace: molecular_function
def: "Binding to a nuclear estrogen receptor." [GOC:ai]
synonym: "estrogen receptor binding" BROAD []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0030332
name: cyclin binding
namespace: molecular_function
def: "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030334
name: regulation of cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
is_a: GO:2000145 ! regulation of cell motility
relationship: regulates GO:0016477 ! cell migration

[Term]
id: GO:0030335
name: positive regulation of cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "activation of cell migration" NARROW []
synonym: "stimulation of cell migration" NARROW []
synonym: "up regulation of cell migration" EXACT []
synonym: "up-regulation of cell migration" EXACT []
synonym: "upregulation of cell migration" EXACT []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000147 ! positive regulation of cell motility
relationship: positively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030336
name: negative regulation of cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "down regulation of cell migration" EXACT []
synonym: "down-regulation of cell migration" EXACT []
synonym: "downregulation of cell migration" EXACT []
synonym: "inhibition of cell migration" NARROW []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000146 ! negative regulation of cell motility
relationship: negatively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030337
name: DNA polymerase processivity factor activity
namespace: molecular_function
def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839]
synonym: "processivity clamp" EXACT []
synonym: "sliding clamp" NARROW [GOC:jh2, PMID:23012374]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0030338
name: CMP-N-acetylneuraminate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O." [EC:1.14.18.2]
comment: Note that this was EC:1.14.13.45.
synonym: "CMP-N-acetylneuraminate hydroxylase activity" RELATED [EC:1.14.18.2]
synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT []
synonym: "CMP-Neu5Ac hydroxylase activity" RELATED [EC:1.14.18.2]
synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" RELATED [EC:1.14.18.2]
xref: EC:1.14.18.2
xref: MetaCyc:1.14.18.2-RXN
xref: RHEA:16145
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0030339
name: fatty-acyl-ethyl-ester synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67]
synonym: "FAEE synthase activity" RELATED [EC:3.1.1.67]
synonym: "FAEES activity" RELATED [EC:3.1.1.67]
synonym: "fatty-acyl ethyl ester synthase" EXACT [GOC:mah]
synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" RELATED [EC:3.1.1.67]
xref: EC:3.1.1.67
xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN
xref: RHEA:16641
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0030340
name: hyaluronate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1]
synonym: "glucuronoglycosaminoglycan lyase activity" RELATED [EC:4.2.2.1]
synonym: "hyaluronidase [but cf. EC:3.2.1.35 (hyalurononglucosaminidase) and EC:3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1]
synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1]
synonym: "mucinase activity" RELATED [EC:4.2.2.1]
synonym: "spreading factor activity" RELATED [EC:4.2.2.1]
xref: EC:4.2.2.1
xref: MetaCyc:HYALURONATE-LYASE-RXN
xref: RHEA:50240
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030341
name: chondroitin AC lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5]
synonym: "ChnAC" RELATED []
synonym: "chondroitin AC eliminase activity" RELATED [EC:4.2.2.5]
synonym: "chondroitin lyase activity" EXACT []
synonym: "chondroitin sulfate lyase activity" RELATED [EC:4.2.2.5]
synonym: "chondroitinase AC" RELATED []
synonym: "chondroitinase activity" BROAD []
xref: EC:4.2.2.5
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030342
name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296]
synonym: "1,25-(OH)2D3 24-hydroxylase activity" EXACT [PMID:8506296]
synonym: "calcitriol 24-hydroxylase activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-209765 "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it"
xref: Reactome:R-HSA-211950 "CYP24A1 24-hydroxylates CTL"
xref: Reactome:R-HSA-5602004 "Defective CYP24A1 does not 24-hydroxylate CALTOL"
xref: RHEA:24964
is_a: GO:0070576 ! vitamin D 24-hydroxylase activity

[Term]
id: GO:0030343
name: vitamin D3 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: calciol (vitamin D3) + reduced [NADPH--hemoprotein reductase] + O2 = calcidiol + oxidized [NADPH--hemoprotein reductase]+ + H2O +H2." [RHEA:32903]
synonym: "cholecalciferol 25-hydroxylase activity" EXACT []
xref: EC:1.14.14.24
xref: MetaCyc:RXN-9829
xref: Reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D"
xref: Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D"
xref: RHEA:32903
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0030345
name: structural constituent of tooth enamel
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah]
is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance

[Term]
id: GO:0030346
name: protein phosphatase 2B binding
namespace: molecular_function
def: "Binding to a protein phosphatase 2B." [GOC:jl]
synonym: "calcineurin binding" EXACT []
synonym: "protein phosphatase 3 binding" RELATED [GOC:dph, GOC:rl]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0030348
name: syntaxin-3 binding
namespace: molecular_function
def: "Binding to a syntaxin-3 SNAP receptor." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0030350
name: iron-responsive element binding
namespace: molecular_function
def: "Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843]
synonym: "IRE binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0030351
name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]
xref: Reactome:R-HSA-1855163 "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen"
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity

[Term]
id: GO:0030352
name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai]
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0030353
name: fibroblast growth factor receptor antagonist activity
namespace: molecular_function
def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah]
synonym: "FGF receptor antagonist activity" EXACT []
synonym: "FGFR antagonist activity" EXACT []
is_a: GO:0005104 ! fibroblast growth factor receptor binding
is_a: GO:0048019 ! receptor antagonist activity

[Term]
id: GO:0030354
name: melanin-concentrating hormone activity
namespace: molecular_function
def: "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0030355
name: obsolete small nucleolar ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "small nucleolar ribonucleoprotein" EXACT []
synonym: "snoRNP" EXACT []
is_obsolete: true
replaced_by: GO:0005732

[Term]
id: GO:0030356
name: obsolete small cytoplasmic ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "scRNP" EXACT []
synonym: "small cytoplasmic ribonucleoprotein" EXACT []
is_obsolete: true
replaced_by: GO:1990904

[Term]
id: GO:0030363
name: obsolete pre-mRNA cleavage factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856]
comment: This term was made obsolete because it describes a biological process.
synonym: "pre-mRNA cleavage factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0030364
name: obsolete cleavage and polyadenylylation specificity factor activity
namespace: molecular_function
def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856]
comment: This term was made obsolete because it describes a cellular component.
synonym: "cleavage and polyadenylation specificity factor activity" EXACT []
synonym: "cleavage and polyadenylylation specificity factor activity" EXACT []
synonym: "cleavage/polyadenylation specificity factor activity" EXACT []
synonym: "CPSF" EXACT []
is_obsolete: true
replaced_by: GO:0005847

[Term]
id: GO:0030365
name: obsolete cleavage stimulation factor activity
namespace: molecular_function
def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856]
comment: This term was made obsolete because it describes a cellular component.
synonym: "cleavage stimulation factor activity" EXACT []
synonym: "CstF" EXACT []
is_obsolete: true
replaced_by: GO:0005848

[Term]
id: GO:0030366
name: molybdopterin synthase activity
namespace: molecular_function
def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783]
xref: EC:2.8.1.12
xref: Reactome:R-HSA-947541 "Sulfhydrylation and ring cleavage of precursor Z"
xref: RHEA:26333
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0030367
name: interleukin-17 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-17 receptor." [GOC:ai]
synonym: "IL-17" NARROW []
synonym: "interleukin-17 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0030368
name: interleukin-17 receptor activity
namespace: molecular_function
def: "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]
synonym: "IL-17 receptor activity" EXACT [GOC:mah]
synonym: "IL-17R" EXACT []
xref: Wikipedia:Interleukin-17_receptor
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0030369
name: ICAM-3 receptor activity
namespace: molecular_function
def: "Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0030370
name: intercellular adhesion molecule-3 receptor binding
namespace: molecular_function
def: "Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836]
synonym: "ICAM-3 receptor binding" EXACT []
synonym: "ICAM-3 receptor ligand" NARROW []
synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0030371
name: translation repressor activity
namespace: molecular_function
def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]
is_a: GO:0045182 ! translation regulator activity

[Term]
id: GO:0030372
name: high molecular weight B cell growth factor receptor binding
namespace: molecular_function
def: "Binding to a high molecular weight B cell growth factor receptor." [GOC:ai]
synonym: "high molecular weight B cell growth factor receptor ligand" NARROW []
synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT []
synonym: "high molecular weight B-cell growth factor receptor binding" EXACT []
synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0030373
name: high molecular weight B cell growth factor receptor activity
namespace: molecular_function
def: "Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:2681271]
synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT []
synonym: "high molecular weight B-cell growth factor receptor activity" EXACT []
synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT []
synonym: "HMW-BCGF receptor" EXACT [PMID:2681271]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0030374
name: obsolete nuclear receptor coactivator activity
namespace: molecular_function
alt_id: GO:0038049
def: "OBSOLETE. A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that these activities are not necessarily specific for nuclear receptors subclass of dbTFs, so that distinction leads to misannotations.
synonym: "ligand-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT []
synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT []
synonym: "ligand-dependent nuclear receptor transcription coactivator activity" EXACT []
synonym: "nuclear receptor transcription coactivator activity" EXACT []
synonym: "transcription factor activity, ligand-activated RNA polymerase II transcription factor binding" EXACT []
is_obsolete: true
replaced_by: GO:0003713

[Term]
id: GO:0030375
name: obsolete thyroid hormone receptor coactivator activity
namespace: molecular_function
alt_id: GO:0010861
def: "OBSOLETE. The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represented a gene product.
synonym: "thyroid hormone receptor activator activity" NARROW []
synonym: "thyroid hormone receptor co-activator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0030377
name: urokinase plasminogen activator receptor activity
namespace: molecular_function
def: "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079]
synonym: "U-plasminogen activator receptor activity" EXACT [GOC:bf]
synonym: "uPAR" EXACT []
synonym: "urokinase plasminogen activator receptor" EXACT []
xref: Wikipedia:Urokinase_receptor
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0030378
name: serine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine = D-serine." [RHEA:10980]
xref: EC:5.1.1.18
xref: MetaCyc:5.1.1.18-RXN
xref: Reactome:R-HSA-9014766 "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser"
xref: RHEA:10980
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0030379
name: neurotensin receptor activity, non-G protein-coupled
namespace: molecular_function
def: "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851]
synonym: "neurotensin receptor activity, non G protein coupled" EXACT []
synonym: "neurotensin receptor activity, non-G-protein coupled" EXACT []
synonym: "non G protein coupled neurotensin receptor activity" EXACT []
synonym: "non-G-protein coupled neurotensin receptor activity" EXACT []
synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0030380
name: interleukin-17E receptor binding
namespace: molecular_function
def: "Binding to an interleukin-17E receptor." [GOC:ai]
synonym: "IL-17E" NARROW []
synonym: "interleukin-17E receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0030381
name: chorion-containing eggshell pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0003002 ! regionalization
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0030382
name: sperm mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
synonym: "sperm mitochondria organisation" EXACT []
synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah]
synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0030383
name: obsolete host-pathogen interaction
namespace: biological_process
def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "host-pathogen interaction" EXACT []
is_obsolete: true
consider: GO:0044403

[Term]
id: GO:0030386
name: ferredoxin-thioredoxin reductase complex
namespace: cellular_component
def: "A protein complex that possesses ferredoxin-thioredoxin reductase activity." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin-thioredoxin reductase activity ; GO:0103012'.
synonym: "ferredoxin:thioredoxin reductase complex" EXACT []
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0030388
name: fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732]
synonym: "fructose 1,6-bisphosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0030389
name: fructosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
synonym: "fructosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:0030391
name: fructosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
synonym: "fructosamine anabolism" EXACT []
synonym: "fructosamine biosynthesis" EXACT []
synonym: "fructosamine formation" EXACT []
synonym: "fructosamine synthesis" EXACT []
is_a: GO:0030389 ! fructosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0030392
name: fructosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
synonym: "fructosamine breakdown" EXACT []
synonym: "fructosamine catabolism" EXACT []
synonym: "fructosamine degradation" EXACT []
is_a: GO:0030389 ! fructosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0030393
name: fructoselysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group." [GOC:ai]
synonym: "fructoselysine metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0030389 ! fructosamine metabolic process

[Term]
id: GO:0030394
name: fructoseglycine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group." [GOC:ai]
synonym: "fructoseglycine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0030389 ! fructosamine metabolic process

[Term]
id: GO:0030395
name: lactose binding
namespace: molecular_function
def: "Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:0192800981]
is_a: GO:0048030 ! disaccharide binding

[Term]
id: GO:0030397
name: membrane disassembly
namespace: biological_process
def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah]
synonym: "membrane breakdown" EXACT []
synonym: "membrane catabolism" EXACT []
synonym: "membrane degradation" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0030398
name: obsolete peroxisomal membrane disassembly
namespace: biological_process
def: "OBSOLETE. The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760]
comment: This trerm was added in error
synonym: "peroxisomal membrane breakdown" EXACT []
synonym: "peroxisomal membrane catabolism" EXACT []
synonym: "peroxisomal membrane degradation" EXACT []
is_obsolete: true
replaced_by: GO:0030242

[Term]
id: GO:0030399
name: autophagosome membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of autophagosomes." [GOC:autophagy, GOC:mah]
synonym: "autophagic membrane breakdown" EXACT []
synonym: "autophagic membrane catabolism" NARROW [GOC:autophagy]
synonym: "autophagic membrane degradation" NARROW [GOC:autophagy]
synonym: "autophagic vacuole membrane disassembly" EXACT [GOC:autophagy]
is_a: GO:0030397 ! membrane disassembly
is_a: GO:1905037 ! autophagosome organization

[Term]
id: GO:0030400
name: obsolete protease substrate recruitment factor activity
namespace: molecular_function
def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370]
comment: This term was made obsolete because it represents a gene product.
synonym: "protease substrate recruitment factor activity" EXACT []
is_obsolete: true
consider: GO:0030674

[Term]
id: GO:0030401
name: obsolete transcription antiterminator activity
namespace: molecular_function
def: "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "transcription antiterminator activity" EXACT []
synonym: "transcriptional antiterminator activity" EXACT []
is_obsolete: true
consider: GO:0001072
consider: GO:0001073
consider: GO:0006353

[Term]
id: GO:0030402
name: obsolete matrilysin-2 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrilysin-2 activity" EXACT []
synonym: "matrix metalloproteinase 26" EXACT []
synonym: "MMP-26" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030403
name: obsolete collagenase 4 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagenase 4 activity" EXACT []
synonym: "matrix metalloproteinase 18" EXACT []
synonym: "MMP-18" NARROW []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030404
name: obsolete collagenase 3 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagenase 3 activity" EXACT []
synonym: "matrix metalloproteinase 13" EXACT []
synonym: "MMP-13" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030405
name: obsolete matrix metalloproteinase 19 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 19 activity" EXACT []
synonym: "MMP-19" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030406
name: obsolete matrix metalloproteinase 25 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 25 activity" EXACT []
synonym: "MMP-25" EXACT []
synonym: "MT6-MMP" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030408
name: glycine formimidoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine." [RHEA:24288]
synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" RELATED [EC:2.1.2.4]
synonym: "FIG formiminotransferase activity" RELATED [EC:2.1.2.4]
synonym: "formimidoyltransferase activity" BROAD []
synonym: "formiminoglycine formiminotransferase activity" RELATED [EC:2.1.2.4]
synonym: "formiminotransferase activity" BROAD []
synonym: "glycine formiminotransferase activity" EXACT []
xref: EC:2.1.2.4
xref: KEGG_REACTION:R02729
xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN
xref: RHEA:24288
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0030409
name: glutamate formimidoyltransferase activity
namespace: molecular_function
alt_id: GO:0030407
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [RHEA:15097]
synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" RELATED [EC:2.1.2.5]
synonym: "formimidoyltransferase activity" BROAD []
synonym: "formiminoglutamic acid transferase activity" RELATED [EC:2.1.2.5]
synonym: "formiminoglutamic formiminotransferase activity" RELATED [EC:2.1.2.5]
synonym: "formiminotransferase activity" BROAD []
synonym: "glutamate formiminotransferase activity" EXACT []
synonym: "glutamate formyltransferase activity" RELATED [EC:2.1.2.5]
xref: EC:2.1.2.5
xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN
xref: RHEA:15097
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0030410
name: nicotianamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine." [EC:2.5.1.43, RHEA:16481]
synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" RELATED [EC:2.5.1.43]
xref: EC:2.5.1.43
xref: KEGG_REACTION:R00075
xref: MetaCyc:2.5.1.43-RXN
xref: RHEA:16481
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0030411
name: scytalone dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O." [EC:4.2.1.94, RHEA:24396]
synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" RELATED [EC:4.2.1.94]
synonym: "scytalone 7,8-hydro-lyase activity" RELATED [EC:4.2.1.94]
xref: EC:4.2.1.94
xref: KEGG_REACTION:R02907
xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN
xref: RHEA:24396
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0030412
name: formimidoyltetrahydrofolate cyclodeaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4." [EC:4.3.1.4, RHEA:22736]
comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases.
synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" RELATED [EC:4.3.1.4]
synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" RELATED [EC:4.3.1.4]
synonym: "formiminotetrahydrofolate cyclodeaminase activity" RELATED [EC:4.3.1.4]
xref: EC:4.3.1.4
xref: KEGG_REACTION:R02302
xref: MetaCyc:4.3.1.4-RXN
xref: Reactome:R-HSA-70920 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate"
xref: RHEA:22736
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0030413
name: competence pheromone activity
namespace: molecular_function
def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645]
is_a: GO:0005186 ! pheromone activity

[Term]
id: GO:0030414
name: peptidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
synonym: "protease inhibitor activity" NARROW [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0061134 ! peptidase regulator activity

[Term]
id: GO:0030415
name: obsolete carboxypeptidase A inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "carboxypeptidase A inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0030414

[Term]
id: GO:0030416
name: methylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylamine (CH3NH2)." [ISBN:0721662544]
synonym: "methylamine metabolism" EXACT []
synonym: "methylammonium metabolic process" EXACT []
synonym: "methylammonium metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0030417
name: nicotianamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
synonym: "nicotianamine metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0030418
name: nicotianamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
synonym: "nicotianamine anabolism" EXACT []
synonym: "nicotianamine biosynthesis" EXACT []
synonym: "nicotianamine formation" EXACT []
synonym: "nicotianamine synthesis" EXACT []
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0030417 ! nicotianamine metabolic process
is_a: GO:0042401 ! biogenic amine biosynthetic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process

[Term]
id: GO:0030419
name: nicotianamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
synonym: "nicotianamine breakdown" EXACT []
synonym: "nicotianamine catabolism" EXACT []
synonym: "nicotianamine degradation" EXACT []
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0030417 ! nicotianamine metabolic process
is_a: GO:0042402 ! biogenic amine catabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process

[Term]
id: GO:0030420
name: establishment of competence for transformation
namespace: biological_process
def: "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027]
is_a: GO:0051716 ! cellular response to stimulus
relationship: part_of GO:0009294 ! DNA-mediated transformation

[Term]
id: GO:0030421
name: defecation
namespace: biological_process
def: "The expulsion of feces from the rectum." [GOC:mah]
xref: Wikipedia:Defecation
is_a: GO:0007588 ! excretion
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0030422
name: siRNA processing
namespace: biological_process
alt_id: GO:0070919
def: "A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase." [GOC:mah, PMID:11524674, PMID:19239886, PMID:20687832]
synonym: "chromatin silencing by small RNA, production of guide RNAs" EXACT []
synonym: "chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah]
synonym: "production of guide RNAs involved in chromatin silencing by small RNA" EXACT [GOC:mah]
synonym: "production of guide RNAs involved in RNA interference" EXACT [GOC:mah]
synonym: "production of siRNA" RELATED []
synonym: "production of siRNA involved in chromatin silencing by small RNA" EXACT []
synonym: "production of siRNA involved in gene silencing by small RNA" NARROW []
synonym: "production of siRNA involved in post-transcriptional gene silencing by RNA" EXACT []
synonym: "production of siRNA involved in PTGS" RELATED []
synonym: "production of siRNA involved in RNA interference" EXACT []
synonym: "RNA interference, production of guide RNAs" EXACT []
synonym: "RNA interference, production of siRNA" EXACT [GOC:mah]
is_a: GO:0070918 ! regulatory ncRNA processing

[Term]
id: GO:0030424
name: axon
namespace: cellular_component
def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
xref: NIF_Subcellular:sao1770195789
xref: Wikipedia:Axon
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0030425
name: dendrite
namespace: cellular_component
def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
xref: NIF_Subcellular:sao1211023249
xref: Wikipedia:Dendrite
is_a: GO:0043005 ! neuron projection
relationship: part_of GO:0097447 ! dendritic tree

[Term]
id: GO:0030426
name: growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]
xref: Wikipedia:Growth_cone
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0150034 ! distal axon

[Term]
id: GO:0030427
name: site of polarized growth
namespace: cellular_component
alt_id: GO:0000134
alt_id: GO:0030483
def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0030428
name: cell septum
namespace: cellular_component
def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526]
subset: goslim_pir
synonym: "cross wall" EXACT []
synonym: "septum" BROAD []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0030429
name: kynureninase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine + H+. Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)- alanines." [EC:3.7.1.3, PMID:17300176]
synonym: "kynurenine hydrolase activity" RELATED [EC:3.7.1.3]
synonym: "L-kynurenine hydrolase activity" RELATED [EC:3.7.1.3]
xref: EC:3.7.1.3
xref: MetaCyc:KYNURENINASE-RXN
xref: Reactome:R-HSA-71217 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine"
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0030430
name: host cell cytoplasm
namespace: cellular_component
alt_id: GO:0097679
def: "The cytoplasm of a host cell." [GOC:mah]
synonym: "other organism cytoplasm" RELATED []
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0030431
name: sleep
namespace: biological_process
def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
subset: goslim_pir
synonym: "diapause" RELATED []
synonym: "dormancy" RELATED []
synonym: "lethargus" RELATED []
xref: Wikipedia:Sleep
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0030432
name: peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732]
xref: Wikipedia:Peristalsis
is_a: GO:0014821 ! phasic smooth muscle contraction

[Term]
id: GO:0030433
name: obsolete ubiquitin-dependent ERAD pathway
namespace: biological_process
def: "OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]
comment: This term was added in error (identical process to the parent term)
is_obsolete: true
replaced_by: GO:0036503

[Term]
id: GO:0030435
name: sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913]
comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo.
synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb]
synonym: "spore biosynthesis" EXACT []
synonym: "spore differentiation" EXACT []
synonym: "spore formation" EXACT []
xref: Wikipedia:Sporogenesis
is_a: GO:0043934 ! sporulation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0030436
name: asexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi." [GOC:mah, PMID:9529886]
synonym: "asexual reproductive sporulation" EXACT []
synonym: "asexual spore formation" EXACT []
synonym: "mitotic spore formation" EXACT []
synonym: "mitotic sporulation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0043934 ! sporulation

[Term]
id: GO:0030437
name: ascospore formation
namespace: biological_process
alt_id: GO:0007151
def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736]
comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked.
subset: goslim_pombe
synonym: "ascospore biosynthesis" EXACT []
synonym: "spore formation" BROAD []
synonym: "sporulation" BROAD []
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore
is_a: GO:0048468 ! cell development
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0030438
name: obsolete MAPKKK cascade during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030439
name: obsolete activation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030440
name: obsolete activation of MAPKK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030441
name: obsolete activation of MAPKKK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030442
name: obsolete inactivation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030443
name: obsolete nuclear translocation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030444
name: obsolete microtubule depolymerization during nuclear congression
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because the entire branch of the ontology was changed.
synonym: "microtubule depolymerization during nuclear congression" EXACT []
is_obsolete: true
replaced_by: GO:0007019

[Term]
id: GO:0030445
name: yeast-form cell wall
namespace: cellular_component
def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc]
comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'.
is_a: GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0030446
name: hyphal cell wall
namespace: cellular_component
def: "The cell wall surrounding a fungal hypha." [GOC:mah]
comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'.
is_a: GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0030447
name: filamentous growth
namespace: biological_process
def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141]
subset: goslim_candida
is_a: GO:0040007 ! growth

[Term]
id: GO:0030448
name: hyphal growth
namespace: biological_process
alt_id: GO:0075061
def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295]
subset: goslim_candida
synonym: "formation of symbiont invasive hypha in host" EXACT []
synonym: "formation of symbiont invasive hypha within host" EXACT []
synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT []
synonym: "invasive hyphal growth" EXACT []
synonym: "symbiont invasive hypha formation within host" EXACT []
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0030449
name: regulation of complement activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "regulation of complement cascade" EXACT [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0002920 ! regulation of humoral immune response
relationship: regulates GO:0006956 ! complement activation

[Term]
id: GO:0030450
name: regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators]
synonym: "regulation of complement cascade, classical pathway" EXACT [GOC:add]
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
is_a: GO:0030449 ! regulation of complement activation
relationship: regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0030451
name: regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators]
synonym: "regulation of complement cascade, alternative pathway" EXACT [GOC:add]
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0030455
name: obsolete MAPKKK cascade (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030456
name: obsolete activation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030457
name: obsolete activation of MAPKK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030458
name: obsolete activation of MAPKKK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030459
name: obsolete inactivation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030460
name: obsolete nuclear translocation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030463
name: obsolete cell aging (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'.
synonym: "cell aging (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030464
name: obsolete aging dependent sterility (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:sgd_curators]
comment: This term was made obsolete because it reflected a trait or phenotype.
synonym: "aging dependent sterility (sensu Fungi)" EXACT []
is_obsolete: true
consider: GO:0030466

[Term]
id: GO:0030465
name: obsolete autophagic death (sensu Fungi)
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because a more correct term has been created.
synonym: "autophagic death (sensu Fungi)" EXACT []
is_obsolete: true
consider: GO:0048102

[Term]
id: GO:0030466
name: silent mating-type cassette heterochromatin formation
namespace: biological_process
alt_id: GO:0006347
alt_id: GO:0035389
def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc]
synonym: "aging-dependent sterility" NARROW []
synonym: "chromatin silencing at HML and HMR" NARROW []
synonym: "chromatin silencing at silent mating-type cassette" EXACT []
synonym: "establishment of chromatin silencing at silent mating-type cassette" RELATED []
synonym: "heterochromatic silencing at silent mating-type cassette" EXACT []
synonym: "silent mating-type cassette chromatin silencing" EXACT [GOC:mah]
synonym: "silent mating-type cassette heterochromatin assembly" EXACT []
is_a: GO:0140719 ! constitutive heterochromatin formation

[Term]
id: GO:0030470
name: obsolete spore germination (sensu Fungi)
namespace: biological_process
alt_id: GO:0007153
def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc]
comment: This term was made obsolete because a sensu term was not needed.
synonym: "germination (sensu Saccharomyces)" NARROW []
synonym: "spore germination (sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0009847

[Term]
id: GO:0030471
name: obsolete spindle pole body and microtubule cycle (sensu Fungi)
namespace: biological_process
alt_id: GO:0007102
def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649]
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
synonym: "spindle pole body and microtubule cycle (sensu Fungi)" EXACT []
synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW []
is_obsolete: true
consider: GO:0007051
consider: GO:0051300

[Term]
id: GO:0030473
name: nuclear migration along microtubule
namespace: biological_process
alt_id: GO:0000065
def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]
synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT []
synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT []
synonym: "microtubule-dependent nuclear positioning" EXACT []
synonym: "microtubule-dependent nucleus positioning" EXACT []
synonym: "microtubule-mediated nuclear migration" EXACT []
synonym: "nuclear migration, microtubule-mediated" EXACT []
synonym: "nuclear movement, microtubule-mediated" BROAD []
synonym: "nucleus migration" BROAD []
synonym: "transport of nucleus by microtubules" EXACT []
synonym: "transport of nucleus, microtubule-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0030474
name: spindle pole body duplication
namespace: biological_process
alt_id: GO:0007103
alt_id: GO:0031046
def: "Construction of a new spindle pole body." [GOC:clt]
synonym: "spindle pole body assembly" EXACT []
synonym: "spindle pole body biogenesis" EXACT []
synonym: "spindle pole body biosynthesis" EXACT []
synonym: "spindle pole body duplication associated with nuclear envelope" EXACT []
synonym: "spindle pole body duplication in cytoplasm" EXACT []
synonym: "spindle pole body formation" EXACT []
synonym: "spindle pole body replication" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0051300 ! spindle pole body organization

[Term]
id: GO:0030476
name: ascospore wall assembly
namespace: biological_process
alt_id: GO:0007152
def: "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385]
synonym: "spore wall assembly" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042244 ! spore wall assembly
is_a: GO:0071940 ! fungal-type cell wall assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0030478
name: actin cap
namespace: cellular_component
alt_id: GO:0000143
def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, PMID:21494665]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030479
name: actin cortical patch
namespace: cellular_component
alt_id: GO:0005857
def: "An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963]
synonym: "actin patch" EXACT []
is_a: GO:0061645 ! endocytic patch
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030484
name: obsolete muscle fiber
namespace: cellular_component
def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194]
comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'.
synonym: "muscle fiber" EXACT []
synonym: "muscle fibre" EXACT []
is_obsolete: true
consider: GO:0043292

[Term]
id: GO:0030485
name: smooth muscle contractile fiber
namespace: cellular_component
def: "The contractile fiber of smooth muscle cells." [GOC:mah]
is_a: GO:0043292 ! contractile muscle fiber

[Term]
id: GO:0030486
name: smooth muscle dense body
namespace: cellular_component
def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030485 ! smooth muscle contractile fiber

[Term]
id: GO:0030487
name: inositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [GOC:mah]
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity

[Term]
id: GO:0030488
name: tRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0030489
name: obsolete processing of 27S pre-rRNA
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators]
comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product.
synonym: "processing of 27S pre-rRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0030490
name: maturation of SSU-rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]
synonym: "processing of 20S pre-rRNA" NARROW []
synonym: "SSU-rRNA maturation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006364 ! rRNA processing
relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis

[Term]
id: GO:0030491
name: heteroduplex formation
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0030492
name: hemoglobin binding
namespace: molecular_function
def: "Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl]
synonym: "globin binding" BROAD []
synonym: "haemoglobin binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030493
name: bacteriochlorophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732]
synonym: "bacteriochlorophyll metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0030494
name: bacteriochlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732]
synonym: "bacteriochlorophyll anabolism" EXACT []
synonym: "bacteriochlorophyll biosynthesis" EXACT []
synonym: "bacteriochlorophyll formation" EXACT []
synonym: "bacteriochlorophyll synthesis" EXACT []
is_a: GO:0015995 ! chlorophyll biosynthetic process
is_a: GO:0030493 ! bacteriochlorophyll metabolic process

[Term]
id: GO:0030495
name: bacteriochlorophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators]
synonym: "bacteriochlorophyll breakdown" EXACT []
synonym: "bacteriochlorophyll catabolism" EXACT []
synonym: "bacteriochlorophyll degradation" EXACT []
is_a: GO:0015996 ! chlorophyll catabolic process
is_a: GO:0030493 ! bacteriochlorophyll metabolic process

[Term]
id: GO:0030496
name: midbody
namespace: cellular_component
def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Midbody_(cell_biology)
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0030497
name: fatty acid elongation
namespace: biological_process
def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0030500
name: regulation of bone mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators]
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0070167 ! regulation of biomineral tissue development
relationship: regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030501
name: positive regulation of bone mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators]
synonym: "activation of bone mineralization" NARROW []
synonym: "stimulation of bone mineralization" NARROW []
synonym: "up regulation of bone mineralization" EXACT []
synonym: "up-regulation of bone mineralization" EXACT []
synonym: "upregulation of bone mineralization" EXACT []
is_a: GO:0030500 ! regulation of bone mineralization
is_a: GO:0045778 ! positive regulation of ossification
is_a: GO:0070169 ! positive regulation of biomineral tissue development
relationship: positively_regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030502
name: negative regulation of bone mineralization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators]
synonym: "down regulation of bone mineralization" EXACT []
synonym: "down-regulation of bone mineralization" EXACT []
synonym: "downregulation of bone mineralization" EXACT []
synonym: "inhibition of bone mineralization" NARROW []
is_a: GO:0030279 ! negative regulation of ossification
is_a: GO:0030500 ! regulation of bone mineralization
is_a: GO:0070168 ! negative regulation of biomineral tissue development
relationship: negatively_regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030504
name: inorganic diphosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of inorganic diphosphate across a membrane." [PMID:11326272]
synonym: "inorganic pyrophosphate transporter activity" EXACT []
xref: Reactome:R-HSA-5226964 "ANKH transports PPi from cytosol to extracellular region"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0030505
name: inorganic diphosphate transport
namespace: biological_process
def: "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "inorganic pyrophosphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0030506
name: ankyrin binding
namespace: molecular_function
def: "Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030507
name: spectrin binding
namespace: molecular_function
def: "Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732]
is_a: GO:0008092 ! cytoskeletal protein binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0030508
name: obsolete thiol-disulfide exchange intermediate activity
namespace: molecular_function
def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah]
comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process.
synonym: "glutaredoxin" NARROW []
synonym: "thiol-disulfide exchange intermediate activity" EXACT []
synonym: "thiol-disulphide exchange intermediate activity" EXACT []
synonym: "thioredoxin" NARROW []
is_obsolete: true
consider: GO:0003756
consider: GO:0015036

[Term]
id: GO:0030509
name: BMP signaling pathway
namespace: biological_process
alt_id: GO:0008101
def: "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]
synonym: "BMP receptor signaling pathway" RELATED []
synonym: "BMP signalling pathway" EXACT []
synonym: "bone morphogenetic protein signaling pathway" EXACT []
synonym: "bone morphogenetic protein signalling pathway" EXACT []
synonym: "decapentaplegic receptor signaling pathway" NARROW [GOC:bf, GOC:sart, GOC:signaling]
synonym: "decapentaplegic receptor signalling pathway" NARROW []
synonym: "decapentaplegic signaling pathway" NARROW []
synonym: "dpp receptor signaling pathway" NARROW []
synonym: "dpp receptor signalling pathway" NARROW []
synonym: "dpp signaling pathway" NARROW [GOC:bf]
is_a: GO:0141091 ! transforming growth factor beta receptor superfamily signaling pathway
relationship: part_of GO:0071773 ! cellular response to BMP stimulus

[Term]
id: GO:0030510
name: regulation of BMP signaling pathway
namespace: biological_process
alt_id: GO:0090097
def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]
synonym: "regulation of BMP receptor signaling pathway" RELATED []
synonym: "regulation of BMP signalling pathway" EXACT []
synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT []
synonym: "regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf]
synonym: "regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah]
synonym: "regulation of decapentaplegic signaling pathway" NARROW []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030511
name: positive regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT []
synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT []
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1903846 ! positive regulation of cellular response to transforming growth factor beta stimulus
relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0030512
name: negative regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah]
synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT []
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0030513
name: positive regulation of BMP signaling pathway
namespace: biological_process
alt_id: GO:0090098
def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
synonym: "activation of BMP signaling pathway" NARROW []
synonym: "positive regulation of BMP receptor signaling pathway" RELATED []
synonym: "positive regulation of BMP signalling pathway" EXACT []
synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT []
synonym: "positive regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf]
synonym: "positive regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah]
synonym: "positive regulation of decapentaplegic signaling pathway" NARROW []
synonym: "stimulation of BMP signaling pathway" NARROW []
synonym: "up regulation of BMP signaling pathway" EXACT []
synonym: "up-regulation of BMP signaling pathway" EXACT []
synonym: "upregulation of BMP signaling pathway" EXACT []
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030514
name: negative regulation of BMP signaling pathway
namespace: biological_process
alt_id: GO:0090099
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]
synonym: "down regulation of BMP signaling pathway" EXACT []
synonym: "down-regulation of BMP signaling pathway" EXACT []
synonym: "downregulation of BMP signaling pathway" EXACT []
synonym: "inhibition of BMP signaling pathway" NARROW []
synonym: "negative regulation of BMP receptor signaling pathway" RELATED []
synonym: "negative regulation of BMP signalling pathway" EXACT []
synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT []
synonym: "negative regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf]
synonym: "negative regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah]
synonym: "negative regulation of decapentaplegic signaling pathway" NARROW []
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
relationship: negatively_regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030515
name: snoRNA binding
namespace: molecular_function
def: "Binding to a small nucleolar RNA." [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0030516
name: regulation of axon extension
namespace: biological_process
def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061387 ! regulation of extent of cell growth
relationship: regulates GO:0048675 ! axon extension

[Term]
id: GO:0030517
name: negative regulation of axon extension
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah]
synonym: "down regulation of axon extension" EXACT []
synonym: "down-regulation of axon extension" EXACT []
synonym: "downregulation of axon extension" EXACT []
synonym: "inhibition of axon extension" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0050771 ! negative regulation of axonogenesis
relationship: negatively_regulates GO:0048675 ! axon extension

[Term]
id: GO:0030518
name: nuclear receptor-mediated steroid hormone signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a steroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "intracellular steroid hormone receptor signaling pathway" EXACT []
synonym: "steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "steroid hormone receptor signalling pathway" BROAD [GOC:bf]
is_a: GO:0043401 ! steroid hormone receptor signaling pathway
is_a: GO:0141193 ! nuclear receptor-mediated signaling pathway

[Term]
id: GO:0030519
name: snoRNP binding
namespace: molecular_function
def: "Binding to a small nucleolar ribonucleoprotein particle." [GOC:mah]
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0030520
name: estrogen receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]
synonym: "estrogen receptor signalling pathway" BROAD [GOC:bf]
synonym: "intracellular estrogen receptor signaling pathway" EXACT []
synonym: "nuclear receptor-mediated estrogen signaling pathway" EXACT []
is_a: GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0030521
name: androgen receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by an androgen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah]
synonym: "androgen receptor signalling pathway" EXACT []
synonym: "nuclear-receptor-mediated androgen receptor signaling pathway" EXACT []
is_a: GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0030522
name: intracellular receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a receptor located within a cell." [GOC:bf, GOC:mah]
synonym: "intracellular receptor mediated signaling pathway" EXACT []
synonym: "intracellular receptor-mediated signaling pathway" EXACT []
synonym: "intracellular receptor-mediated signalling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0030526
name: granulocyte macrophage colony-stimulating factor receptor complex
namespace: cellular_component
def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah]
synonym: "GM-CSF receptor complex" EXACT [GOC:vk]
synonym: "granulocyte macrophage colony stimulating factor receptor complex" EXACT []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0030527
name: structural constituent of chromatin
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0030528
name: obsolete transcription regulator activity
namespace: molecular_function
def: "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "transcription regulator activity" EXACT []
synonym: "transcriptional regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0140110

[Term]
id: GO:0030530
name: obsolete heterogeneous nuclear ribonucleoprotein complex
namespace: cellular_component
def: "OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732]
comment: This term was made because heterogeneous nuclear ribonucleoprotein is an experimental construct and does not correspond cleanly to a functional cellular entity.
synonym: "heterogeneous nuclear ribonucleoprotein" EXACT []
synonym: "heterogeneous nuclear ribonucleoprotein complex" EXACT []
synonym: "hnRNP" EXACT []
xref: Wikipedia:Heterogeneous_ribonucleoprotein_particle
is_obsolete: true
consider: GO:0005681
consider: GO:1990904

[Term]
id: GO:0030531
name: obsolete small cytoplasmic ribonucleoprotein complex
namespace: cellular_component
def: "OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah]
comment: This term was made obsolete because it was not clearly defined.
synonym: "scRNP" EXACT []
synonym: "small cytoplasmic ribonucleoprotein" EXACT []
synonym: "small cytoplasmic ribonucleoprotein complex" EXACT []
is_obsolete: true
replaced_by: GO:1990904

[Term]
id: GO:0030532
name: small nuclear ribonucleoprotein complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: goslim_pir
synonym: "small nuclear ribonucleoprotein" EXACT []
synonym: "snRNP" EXACT []
xref: Wikipedia:SnRNP
is_a: GO:0120114 ! Sm-like protein family complex
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0030533
name: triplet codon-amino acid adaptor activity
namespace: molecular_function
def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732]
comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_yeast
synonym: "transfer RNA" RELATED []
synonym: "tRNA" RELATED []
is_a: GO:0003729 ! mRNA binding
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0030534
name: adult behavior
namespace: biological_process
def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "adult behavioral response to stimulus" EXACT []
synonym: "adult behaviour" EXACT []
synonym: "adult behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0030535
name: obsolete adult feeding behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "adult feeding behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0008343

[Term]
id: GO:0030536
name: larval feeding behavior
namespace: biological_process
def: "Feeding behavior in a larval (immature) organism." [GOC:mah]
comment: See also the biological process term 'feeding behavior ; GO:0007631'.
synonym: "larval feeding behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0030537 ! larval behavior

[Term]
id: GO:0030537
name: larval behavior
namespace: biological_process
alt_id: GO:0017037
def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "larval behaviour" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0030538
name: embryonic genitalia morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf]
synonym: "embryonic genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0048562 ! embryonic organ morphogenesis

[Term]
id: GO:0030539
name: male genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888]
synonym: "male genital development" EXACT []
is_a: GO:0048806 ! genitalia development
is_a: GO:0061458 ! reproductive system development
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0030540
name: female genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah]
synonym: "female genital development" EXACT []
is_a: GO:0048806 ! genitalia development
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0030541
name: plasmid partitioning
namespace: biological_process
alt_id: GO:0030542
def: "Any process in which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah]
is_a: GO:0006276 ! plasmid maintenance

[Term]
id: GO:0030543
name: 2-micrometer plasmid partitioning
namespace: biological_process
def: "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah]
is_a: GO:0030541 ! plasmid partitioning

[Term]
id: GO:0030544
name: Hsp70 protein binding
namespace: molecular_function
def: "Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]
is_a: GO:0031072 ! heat shock protein binding
is_a: GO:0051087 ! protein-folding chaperone binding

[Term]
id: GO:0030545
name: signaling receptor regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a receptor." [GOC:ceb]
synonym: "receptor regulator activity" BROAD []
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0030546
name: signaling receptor activator activity
namespace: molecular_function
def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb]
synonym: "receptor activator activity" BROAD []
synonym: "signalling receptor activator activity" EXACT []
is_a: GO:0030545 ! signaling receptor regulator activity
is_a: GO:0140677 ! molecular function activator activity

[Term]
id: GO:0030547
name: signaling receptor inhibitor activity
namespace: molecular_function
def: "Binds to and modulates the activity of a signaling receptor." [GOC:ceb]
synonym: "receptor inhibitor activity" BROAD []
is_a: GO:0030545 ! signaling receptor regulator activity
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0030548
name: acetylcholine receptor regulator activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah]
is_a: GO:0099602 ! neurotransmitter receptor regulator activity

[Term]
id: GO:0030549
name: acetylcholine receptor activator activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah]
is_a: GO:0030546 ! signaling receptor activator activity
is_a: GO:0030548 ! acetylcholine receptor regulator activity

[Term]
id: GO:0030550
name: acetylcholine receptor inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of an acetylcholine receptor." [GOC:mah]
is_a: GO:0030547 ! signaling receptor inhibitor activity
is_a: GO:0030548 ! acetylcholine receptor regulator activity

[Term]
id: GO:0030551
name: cyclic nucleotide binding
namespace: molecular_function
def: "Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0030552
name: cAMP binding
namespace: molecular_function
def: "Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]
synonym: "3',5' cAMP binding" EXACT []
synonym: "3',5'-cAMP binding" EXACT []
synonym: "adenosine 3',5'-cyclophosphate binding" EXACT []
synonym: "cyclic AMP binding" EXACT []
xref: Reactome:R-HSA-111925 "cAMP induces dissociation of inactive PKA tetramers"
xref: Reactome:R-HSA-381608 "cAMP activates EPAC2"
xref: Reactome:R-HSA-381668 "cAMP activates EPAC1"
xref: Reactome:R-HSA-381707 "PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP"
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0030553
name: cGMP binding
namespace: molecular_function
def: "Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
synonym: "3',5' cGMP binding" EXACT []
synonym: "3',5'-cGMP binding" EXACT []
synonym: "cyclic GMP binding" EXACT []
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0030554
name: adenyl nucleotide binding
namespace: molecular_function
def: "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]
subset: goslim_chembl
is_a: GO:0017076 ! purine nucleotide binding

[Term]
id: GO:0030555
name: RNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
subset: goslim_yeast
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0030556
name: rRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0019843 ! rRNA binding
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030557
name: tRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000049 ! tRNA binding
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030558
name: RNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030559
name: rRNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030556 ! rRNA modification guide activity
is_a: GO:0030558 ! RNA pseudouridylation guide activity

[Term]
id: GO:0030560
name: tRNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030557 ! tRNA modification guide activity
is_a: GO:0030558 ! RNA pseudouridylation guide activity

[Term]
id: GO:0030561
name: RNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030562
name: rRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030556 ! rRNA modification guide activity
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity

[Term]
id: GO:0030563
name: snRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity
is_a: GO:0030566 ! snRNA modification guide activity

[Term]
id: GO:0030564
name: tRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030557 ! tRNA modification guide activity
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity

[Term]
id: GO:0030565
name: snRNA pseudouridylation guide activity
namespace: molecular_function
def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
is_a: GO:0030558 ! RNA pseudouridylation guide activity
is_a: GO:0030566 ! snRNA modification guide activity

[Term]
id: GO:0030566
name: snRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0017069 ! snRNA binding
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030567
name: obsolete thrombin activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "prothrombin activator activity" RELATED [GOC:dph, GOC:tb]
synonym: "thrombin activator activity" EXACT []
is_obsolete: true
replaced_by: GO:0016504

[Term]
id: GO:0030568
name: obsolete plasmin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "plasmin inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030569
name: obsolete chymotrypsin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term.
synonym: "chymotrypsin inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030570
name: pectate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2]
synonym: "(1->4)-alpha-D-galacturonan lyase activity" RELATED [EC:4.2.2.2]
synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" RELATED [EC:4.2.2.2]
synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" RELATED [EC:4.2.2.2]
synonym: "endogalacturonate transeliminase activity" RELATED [EC:4.2.2.2]
synonym: "endopectin methyltranseliminase activity" RELATED [EC:4.2.2.2]
synonym: "pectate transeliminase activity" RELATED [EC:4.2.2.2]
synonym: "pectic acid lyase activity" RELATED [EC:4.2.2.2]
synonym: "pectic acid transeliminase activity" RELATED [EC:4.2.2.2]
synonym: "pectic lyase activity" BROAD [EC:4.2.2.2]
synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2]
synonym: "PGA lyase activity" RELATED [EC:4.2.2.2]
synonym: "polygalacturonate lyase activity" RELATED [EC:4.2.2.2]
synonym: "polygalacturonic acid lyase activity" RELATED [EC:4.2.2.2]
synonym: "polygalacturonic acid trans-eliminase activity" RELATED [EC:4.2.2.2]
synonym: "polygalacturonic transeliminase activity" RELATED [EC:4.2.2.2]
synonym: "PPase-N activity" RELATED [EC:4.2.2.2]
xref: EC:4.2.2.2
xref: MetaCyc:4.2.2.2-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030572
name: phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group." [GOC:mb]
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0030573
name: bile acid catabolic process
namespace: biological_process
alt_id: GO:0019613
def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW []
synonym: "bile acid breakdown" EXACT []
synonym: "bile acid catabolism" EXACT []
synonym: "bile acid degradation" EXACT []
synonym: "cholate catabolic process" NARROW []
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0030574
name: collagen catabolic process
namespace: biological_process
def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]
synonym: "collagen breakdown" EXACT []
synonym: "collagen catabolism" EXACT []
synonym: "collagen degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0032963 ! collagen metabolic process

[Term]
id: GO:0030575
name: nuclear body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah]
synonym: "nuclear body organisation" EXACT []
synonym: "nuclear body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0030576
name: Cajal body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]
comment: See also the cellular component term 'Cajal body ; GO:0015030'.
synonym: "Cajal body organisation" EXACT []
synonym: "Cajal body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030577
name: Lands organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863]
comment: See also the cellular component term 'Lands ; GO:0016606'.
synonym: "Lands organisation" EXACT []
synonym: "Lands organization and biogenesis" RELATED [GOC:mah]
synonym: "LYSP100-associated nuclear domain organization" EXACT [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030578
name: PML body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078]
comment: See also the cellular component term 'PML body ; GO:0016605'.
synonym: "PML body organisation" EXACT []
synonym: "PML body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030579
name: obsolete ubiquitin-dependent SMAD protein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators]
comment: The reason for obsoletion is that the substrate should be captured as the input.
synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT []
synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT []
synonym: "ubiquitin-dependent SMAD protein degradation" EXACT []
is_obsolete: true
replaced_by: GO:0006511

[Term]
id: GO:0030580
name: obsolete quinone cofactor methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb]
comment: This term was obsoleted because it was an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0008425

[Term]
id: GO:0030581
name: symbiont intracellular protein transport in host
namespace: biological_process
alt_id: GO:0051708
def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]
synonym: "host cell protein transport" EXACT []
synonym: "intracellular protein transport in host" EXACT []
synonym: "intracellular protein transport in other organism during symbiotic interaction" BROAD [GOC:dph]
synonym: "intracellular protein transport in other organism involved in symbiotic interaction" BROAD []
is_a: GO:0015031 ! protein transport
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0030582
name: reproductive fruiting body development
namespace: biological_process
def: "The process whose specific outcome is the progression of a reproductive fruiting body over time, from its formation to the mature structure. A reproductive fruiting body is a multicellular reproductive structure that contains spores." [GOC:mah, GOC:mtg_sensu]
comment: This term describes the development of a fruiting body that is a spore-bearing organ. It is not intended to describe the development of myxococcal fruiting bodies.
synonym: "fruiting body formation" EXACT []
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0030583
name: myxococcal fruiting body development
namespace: biological_process
alt_id: GO:0055084
def: "The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786]
comment: For example, as seen in myxobacterium. It is not intended to describe fruiting body development as is Dictyostelium.
synonym: "fruiting body development in cellular response to starvation" BROAD []
synonym: "fruiting body development in response to starvation" BROAD []
is_a: GO:0032502 ! developmental process
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0030584
name: sporocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu]
synonym: "fruiting body development" BROAD []
is_a: GO:0030582 ! reproductive fruiting body development

[Term]
id: GO:0030585
name: phosphoenolpyruvate carboxykinase (diphosphate) activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate." [EC:4.1.1.38, RHEA:22356]
synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" RELATED [EC:4.1.1.38]
synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.38]
synonym: "PEP carboxyphosphotransferase activity" RELATED [EC:4.1.1.38]
synonym: "PEPCTrP" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" RELATED [EC:4.1.1.38]
synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38]
synonym: "phosphopyruvate carboxykinase (pyrophosphate)" RELATED [EC:4.1.1.38]
synonym: "phosphopyruvate carboxylase (pyrophosphate)" RELATED [EC:4.1.1.38]
xref: EC:4.1.1.38
xref: KEGG_REACTION:R00346
xref: MetaCyc:4.1.1.38-RXN
xref: RHEA:22356
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0030586
name: [methionine synthase] reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [RHEA:23908]
synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED []
synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT []
synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" RELATED [EC:1.16.1.8]
synonym: "methionine synthase reductase activity" RELATED [EC:1.16.1.8]
synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" RELATED [EC:1.16.1.8]
synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" RELATED [EC:1.16.1.8]
xref: EC:1.16.1.8
xref: MetaCyc:2.1.1.135-RXN
xref: Reactome:R-HSA-3149518 "MTRR reduces cob(II)alamin to meCbl"
xref: RHEA:23908
is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[Term]
id: GO:0030587
name: sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4332228]
synonym: "fruiting body development" BROAD []
synonym: "fruiting body formation" BROAD []
synonym: "sorocarp biosynthesis" EXACT []
synonym: "sorocarp formation" EXACT []
is_a: GO:0099120 ! socially cooperative development

[Term]
id: GO:0030588
name: pseudocleavage
namespace: biological_process
def: "Partial constriction of the cytoplasm of a cell to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:30990821, PMID:7729583]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0030589
name: pseudocleavage involved in syncytial blastoderm formation
namespace: biological_process
def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
synonym: "pseudocleavage during syncytial blastoderm formation" RELATED [GOC:dph]
is_a: GO:0030588 ! pseudocleavage
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0030590
name: first cell cycle pseudocleavage
namespace: biological_process
def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583]
is_a: GO:0030588 ! pseudocleavage

[Term]
id: GO:0030591
name: 2'-deoxyguanosine DNA ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983]
synonym: "NAD DNA ADP-ribosyltransferase activity" BROAD []
is_a: GO:0140294 ! NAD DNA ADP-ribosyltransferase activity

[Term]
id: GO:0030592
name: DNA ADP-ribosylation
namespace: biological_process
def: "The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA." [PMID:11592983, PMID:27471034, PMID:29361132, PMID:29520010]
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0030593
name: neutrophil chemotaxis
namespace: biological_process
def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732]
is_a: GO:0071621 ! granulocyte chemotaxis
is_a: GO:1990266 ! neutrophil migration

[Term]
id: GO:0030594
name: neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]
comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity'
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0030595
name: leukocyte chemotaxis
namespace: biological_process
def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl]
synonym: "immune cell chemotaxis" EXACT []
synonym: "leucocyte chemotaxis" EXACT []
is_a: GO:0050900 ! leukocyte migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0030596
name: alpha-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40]
synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40]
synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40]
synonym: "alpha-L-rhamnoside rhamnohydrolase activity" RELATED [EC:3.2.1.40]
xref: EC:3.2.1.40
xref: KEGG_REACTION:R02436
xref: MetaCyc:3.2.1.40-RXN
xref: RHEA:17465
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0030597
name: RNA glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah]
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0030598
name: rRNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah]
synonym: "gelonin" RELATED [EC:3.2.2.22]
synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22]
synonym: "momorcochin-S" RELATED [EC:3.2.2.22]
synonym: "nigrin b" RELATED [EC:3.2.2.22]
synonym: "ribosomal ribonucleate N-glycosidase activity" RELATED [EC:3.2.2.22]
synonym: "ricin" RELATED [EC:3.2.2.22]
synonym: "RNA N-glycosidase activity" RELATED [EC:3.2.2.22]
synonym: "rRNA N-glycohydrolase activity" RELATED [EC:3.2.2.22]
synonym: "rRNA N-glycosidase activity" EXACT []
synonym: "saporins" RELATED [EC:3.2.2.22]
xref: EC:3.2.2.22
xref: MetaCyc:3.2.2.22-RXN
is_a: GO:0030597 ! RNA glycosylase activity
is_a: GO:0140102 ! catalytic activity, acting on a rRNA

[Term]
id: GO:0030599
name: pectinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11]
synonym: "pectase activity" RELATED [EC:3.1.1.11]
synonym: "pectin demethoxylase activity" RELATED [EC:3.1.1.11]
synonym: "pectin methoxylase activity" RELATED [EC:3.1.1.11]
synonym: "pectin methyl esterase activity" RELATED [EC:3.1.1.11]
synonym: "pectin methylesterase activity" EXACT []
synonym: "pectin pectylhydrolase activity" RELATED [EC:3.1.1.11]
synonym: "pectinoesterase activity" RELATED [EC:3.1.1.11]
xref: EC:3.1.1.11
xref: MetaCyc:RXN-19782
xref: RHEA:22380
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0030600
name: feruloyl esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73]
synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" RELATED [EC:3.1.1.73]
synonym: "cinnAE" RELATED [EC:3.1.1.73]
synonym: "cinnamoyl ester hydrolase activity" EXACT []
synonym: "FAE-I" RELATED [EC:3.1.1.73]
synonym: "FAE-II" RELATED [EC:3.1.1.73]
synonym: "FAE-III" RELATED [EC:3.1.1.73]
synonym: "FAEA" RELATED [EC:3.1.1.73]
synonym: "ferulic acid esterase activity" RELATED [EC:3.1.1.73]
synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73]
synonym: "hydroxycinnamoyl esterase activity" RELATED [EC:3.1.1.73]
xref: EC:3.1.1.73
xref: MetaCyc:3.1.1.73-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0030601
name: obsolete aminopeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminopeptidase B activity" EXACT []
synonym: "arginyl aminopeptidase activity" EXACT []
synonym: "arylamidase II" RELATED [EC:3.4.11.6]
synonym: "Cl--activated arginine aminopeptidase activity" RELATED [EC:3.4.11.6]
synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6]
synonym: "L-arginine aminopeptidase activity" RELATED [EC:3.4.11.6]
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0030602
name: obsolete chymosin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4]
comment: This term was made obsolete because it represents a gene product.
synonym: "chymosin activity" EXACT []
synonym: "rennin" RELATED [EC:3.4.23.4]
synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0030603
name: oxaloacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oxaloacetate = acetate + H+ + oxalate." [EC:3.7.1.1, RHEA:24432]
synonym: "oxalacetic hydrolase activity" RELATED [EC:3.7.1.1]
synonym: "oxaloacetate acetylhydrolase activity" RELATED [EC:3.7.1.1]
xref: EC:3.7.1.1
xref: KEGG_REACTION:R00338
xref: MetaCyc:OXALOACETASE-RXN
xref: RHEA:24432
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0030604
name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH." [EC:1.1.1.267, RHEA:13717]
synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" RELATED [EC:1.1.1.267]
synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" RELATED [EC:1.1.1.267]
synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" RELATED [EC:1.1.1.267]
synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" RELATED [EC:1.1.1.267]
synonym: "DOXP reductoisomerase activity" EXACT []
synonym: "DXP-reductoisomerase activity" RELATED [EC:1.1.1.267]
xref: EC:1.1.1.267
xref: KEGG_REACTION:R05688
xref: MetaCyc:DXPREDISOM-RXN
xref: RHEA:13717
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030611
name: arsenate reductase activity
namespace: molecular_function
def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0030612
name: arsenate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin." [MetaCyc:RXN-10737]
xref: MetaCyc:RXN-10737
is_a: GO:0030611 ! arsenate reductase activity

[Term]
id: GO:0030613
name: oxidoreductase activity, acting on phosphorus or arsenic in donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.20.-.-]
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW []
xref: EC:1.20.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0030614
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah]
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT []
xref: EC:1.20.4.-
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0030616
name: obsolete transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
namespace: molecular_function
def: "OBSOLETE. A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]
comment: This term was obsoleted because it is redundant with other terms.
synonym: "co-SMAD protein" RELATED [GOC:rl]
synonym: "common mediator SMAD protein" RELATED [GOC:rl]
synonym: "common partner SMAD protein" RELATED [GOC:rl]
synonym: "common-mediator SMAD protein" RELATED [GOC:rl]
synonym: "common-partner SMAD protein" RELATED []
synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0003712

[Term]
id: GO:0030617
name: obsolete transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
namespace: molecular_function
def: "OBSOLETE. A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503]
comment: This term was obsoleted because it represents the same activity as GO:0140416 ; DNA-binding transcription factor inhibitor activity', occurs in cytosol.
synonym: "inhibitory SMAD protein" RELATED []
synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT []
is_obsolete: true
consider: GO:0140416

[Term]
id: GO:0030618
name: obsolete transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
namespace: molecular_function
def: "OBSOLETE. A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]
comment: This term was obsoleted because it is redundant with other terms.
synonym: "pathway restricted SMAD protein" RELATED [GOC:rl]
synonym: "pathway-restricted SMAD protein" RELATED [GOC:rl]
synonym: "pathway-specific SMAD protein" RELATED []
synonym: "receptor regulated SMAD protein" RELATED [GOC:rl]
synonym: "receptor-regulated SMAD protein" RELATED [GOC:rl]
synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0003712

[Term]
id: GO:0030619
name: U1 snRNA binding
namespace: molecular_function
def: "Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]
comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030620
name: U2 snRNA binding
namespace: molecular_function
def: "Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030621
name: U4 snRNA binding
namespace: molecular_function
def: "Binding to a U4 small nuclear RNA (U4 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030622
name: U4atac snRNA binding
namespace: molecular_function
def: "Binding to a U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030623
name: U5 snRNA binding
namespace: molecular_function
def: "Binding to a U5 small nuclear RNA (U5 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030624
name: U6atac snRNA binding
namespace: molecular_function
def: "Binding to a U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030625
name: U11 snRNA binding
namespace: molecular_function
def: "Binding to a U11 small nuclear RNA (U11 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030626
name: U12 snRNA binding
namespace: molecular_function
def: "Binding to a U12 small nuclear RNA (U12 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030627
name: pre-mRNA 5'-splice site binding
namespace: molecular_function
def: "Binding to a pre-mRNA 5' splice site sequence." [GOC:jl]
synonym: "pre-mRNA 5' splice site binding" EXACT []
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0030628
name: pre-mRNA 3'-splice site binding
namespace: molecular_function
def: "Binding to a pre-mRNA 3' splice site sequence." [GOC:jl]
synonym: "pre-mRNA 3' splice site binding" EXACT []
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0030629
name: U6 snRNA 3'-end binding
namespace: molecular_function
def: "Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end." [GOC:mah]
comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs).
synonym: "U6 snRNA 3' end binding" EXACT []
is_a: GO:0017070 ! U6 snRNA binding

[Term]
id: GO:0030631
name: pyrrolysine incorporation
namespace: biological_process
def: "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321]
synonym: "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT [RESID:AA0321]
synonym: "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT []
xref: RESID:AA0321
is_a: GO:0006451 ! translational readthrough

[Term]
id: GO:0030632
name: D-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [GOC:jsg, GOC:mah]
synonym: "D-alanine anabolism" EXACT []
synonym: "D-alanine biosynthesis" EXACT []
synonym: "D-alanine formation" EXACT []
synonym: "D-alanine synthesis" EXACT []
is_a: GO:0006523 ! alanine biosynthetic process
is_a: GO:0046436 ! D-alanine metabolic process
is_a: GO:0046437 ! D-amino acid biosynthetic process

[Term]
id: GO:0030633
name: obsolete D-alanine family amino acid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "D-alanine family amino acid breakdown" EXACT []
synonym: "D-alanine family amino acid catabolism" EXACT []
synonym: "D-alanine family amino acid degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0030634
name: carbon fixation by acetyl-CoA pathway
namespace: biological_process
def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093]
synonym: "acetyl CoA pathway" RELATED [GOC:cjm, PMID:14602585]
synonym: "Ljungdahl-Wood pathway" EXACT []
synonym: "reductive acetyl CoA pathway" EXACT [GOC:cjm, PMID:18801467]
xref: MetaCyc:CODH-PWY
xref: Wikipedia:Wood-Ljungdahl_pathway
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0015977 ! carbon fixation

[Term]
id: GO:0030635
name: obsolete acetate derivative metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah]
comment: This term was made obsolete because it is an unnecessary grouping term, and has been replaced by terms to describe metabolism of specific compounds.
synonym: "acetate derivative metabolic process" EXACT []
synonym: "acetate derivative metabolism" EXACT []
is_obsolete: true
consider: GO:1900619

[Term]
id: GO:0030636
name: obsolete acetate derivative biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah]
comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds.
synonym: "acetate derivative anabolism" EXACT []
synonym: "acetate derivative biosynthesis" EXACT []
synonym: "acetate derivative biosynthetic process" EXACT []
synonym: "acetate derivative formation" EXACT []
synonym: "acetate derivative synthesis" EXACT []
is_obsolete: true
consider: GO:1900620

[Term]
id: GO:0030637
name: obsolete acetate derivative catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai]
comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds.
synonym: "acetate derivative breakdown" EXACT []
synonym: "acetate derivative catabolic process" EXACT []
synonym: "acetate derivative catabolism" EXACT []
synonym: "acetate derivative degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0030638
name: polyketide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]
synonym: "polyketide metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0030639
name: polyketide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]
synonym: "polyketide anabolism" EXACT []
synonym: "polyketide biosynthesis" EXACT []
synonym: "polyketide formation" EXACT []
synonym: "polyketide synthesis" EXACT []
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0030640
name: polyketide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]
synonym: "polyketide breakdown" EXACT []
synonym: "polyketide catabolism" EXACT []
synonym: "polyketide degradation" EXACT []
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0030641
name: regulation of cellular pH
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb]
synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "proton homeostasis" EXACT []
is_a: GO:0006885 ! regulation of pH
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis

[Term]
id: GO:0030642
name: intracellular sulfate ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of sulfate ions within a cell." [GOC:mah, PMID:24193406]
synonym: "cellular sulfate ion homeostasis" EXACT []
synonym: "sulphate ion homeostasis" BROAD []
is_a: GO:0055063 ! sulfate ion homeostasis
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0030643
name: intracellular phosphate ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell." [GOC:mah]
subset: goslim_pombe
synonym: "cellular phosphate ion homeostasis" EXACT []
synonym: "intracellular phosphate homeostasis" BROAD []
synonym: "intracellular Pi homeostasis" EXACT []
is_a: GO:0055062 ! phosphate ion homeostasis
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0030644
name: intracellular chloride ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell." [GOC:mah]
synonym: "cellular chloride ion homeostasis" EXACT []
is_a: GO:0030002 ! intracellular monoatomic anion homeostasis
is_a: GO:0055064 ! chloride ion homeostasis

[Term]
id: GO:0030645
name: glucose catabolic process to butyrate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732]
synonym: "butyrate fermentation" EXACT []
synonym: "glucose fermentation to butyrate" EXACT []
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006113 ! fermentation
is_a: GO:0019605 ! butyrate metabolic process

[Term]
id: GO:0030647
name: aminoglycoside antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]
synonym: "aminoglycoside antibiotic metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0030648
name: aminoglycoside antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]
synonym: "aminoglycoside antibiotic anabolism" EXACT []
synonym: "aminoglycoside antibiotic biosynthesis" EXACT []
synonym: "aminoglycoside antibiotic formation" EXACT []
synonym: "aminoglycoside antibiotic synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:0030649
name: aminoglycoside antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]
synonym: "aminoglycoside antibiotic breakdown" EXACT []
synonym: "aminoglycoside antibiotic catabolism" EXACT []
synonym: "aminoglycoside antibiotic degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:0030650
name: peptide antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah]
synonym: "peptide antibiotic metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0030651
name: peptide antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah]
synonym: "peptide antibiotic anabolism" EXACT []
synonym: "peptide antibiotic biosynthesis" EXACT []
synonym: "peptide antibiotic formation" EXACT []
synonym: "peptide antibiotic synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0030652
name: peptide antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah]
synonym: "peptide antibiotic breakdown" EXACT []
synonym: "peptide antibiotic catabolism" EXACT []
synonym: "peptide antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0030653
name: beta-lactam antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]
synonym: "beta-lactam antibiotic metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:0030654
name: beta-lactam antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]
synonym: "beta-lactam antibiotic anabolism" EXACT []
synonym: "beta-lactam antibiotic biosynthesis" EXACT []
synonym: "beta-lactam antibiotic formation" EXACT []
synonym: "beta-lactam antibiotic synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0072339 ! lactam biosynthetic process

[Term]
id: GO:0030655
name: beta-lactam antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]
synonym: "beta-lactam antibiotic breakdown" EXACT []
synonym: "beta-lactam antibiotic catabolism" EXACT []
synonym: "beta-lactam antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0072340 ! lactam catabolic process

[Term]
id: GO:0030656
name: regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah]
synonym: "regulation of vitamin metabolism" EXACT []
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0030657
name: obsolete regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030658
name: transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah]
synonym: "constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0030133 ! transport vesicle

[Term]
id: GO:0030659
name: cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
is_a: GO:0012506 ! vesicle membrane
relationship: part_of GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0030660
name: Golgi-associated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]
synonym: "Golgi vesicle membrane" RELATED []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0030661
name: chitosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chitosome." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0045009 ! chitosome

[Term]
id: GO:0030662
name: coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0030135 ! coated vesicle

[Term]
id: GO:0030663
name: COPI-coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah]
synonym: "COPI coated vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030665
name: clathrin-coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]
synonym: "clathrin coated vesicle membrane" NARROW [GOC:sl]
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030666
name: endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0030139 ! endocytic vesicle

[Term]
id: GO:0030667
name: secretory granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a secretory granule." [GOC:mah]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0030668
name: merozoite dense granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0020026 ! merozoite dense granule

[Term]
id: GO:0030669
name: clathrin-coated endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah]
is_a: GO:0030665 ! clathrin-coated vesicle membrane
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle

[Term]
id: GO:0030670
name: phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah]
synonym: "phagosome membrane" EXACT [GOC:mah]
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0030671
name: clathrin-coated phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah]
is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle

[Term]
id: GO:0030672
name: synaptic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]
subset: goslim_synapse
is_a: GO:0099501 ! exocytic vesicle membrane
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0030673
name: axolemma
namespace: cellular_component
def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [PMID:9527135]
synonym: "axonal membrane" EXACT [GOC:vk]
xref: NIF_Subcellular:sao250772229
xref: Wikipedia:Axolemma
is_a: GO:0032589 ! neuron projection membrane
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0030674
name: protein-macromolecule adaptor activity
namespace: molecular_function
def: "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]
subset: goslim_chembl
subset: goslim_yeast
synonym: "protein binding, bridging" EXACT []
synonym: "protein complex scaffold activity" BROAD []
synonym: "protein recruiting activity" RELATED []
synonym: "protein-containing complex scaffold activity" BROAD []
synonym: "protein-protein adaptor" NARROW []
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0030677
name: ribonuclease P complex
namespace: cellular_component
def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]
comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA.
subset: goslim_pir
synonym: "RNase P complex" EXACT []
is_a: GO:1902555 ! endoribonuclease complex
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0030678
name: mitochondrial ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans." [GOC:mah, PMID:12045094, PMID:27187488]
synonym: "mitochondrial RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex
is_a: GO:0098798 ! mitochondrial protein-containing complex

[Term]
id: GO:0030679
name: cyanelle ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
synonym: "cyanelle RNase P complex" EXACT []
is_a: GO:0030681 ! multimeric ribonuclease P complex
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0030680
name: dimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094]
synonym: "dimeric RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030681
name: multimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094]
synonym: "multimeric RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030682
name: symbiont-mediated perturbation of host defenses
namespace: biological_process
alt_id: GO:0044413
alt_id: GO:0044415
alt_id: GO:0051807
alt_id: GO:0051832
alt_id: GO:0051834
def: "A process in which a symbiont alters or subverts the normal execution of a host organism's defense response. The host defense response is mounted by the host in response to the presence of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "avoidance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "avoidance of defenses of other organism involved in symbiotic interaction" NARROW []
synonym: "avoidance of host defences" NARROW []
synonym: "avoidance of host defenses" NARROW []
synonym: "evasion of host defence response" NARROW []
synonym: "evasion of other organism defence response" NARROW []
synonym: "evasion or tolerance of defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "evasion or tolerance of defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "evasion or tolerance of defenses of other organism" RELATED []
synonym: "evasion or tolerance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "evasion or tolerance of defenses of other organism involved in symbiotic interaction" RELATED []
synonym: "evasion or tolerance of host defense response" NARROW []
synonym: "evasion or tolerance of host defenses" RELATED []
synonym: "mitigation of host defenses by symbiont" EXACT []
synonym: "perturbation of host defenses by symbiont" EXACT []
is_a: GO:0052200 ! symbiont-mediated response to host defenses

[Term]
id: GO:0030684
name: preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]
subset: goslim_pir
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0030685
name: obsolete nucleolar preribosome
namespace: cellular_component
def: "OBSOLETE. Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516]
comment: The reason for obsoletion is that this term was added in error (combines a component and a localization)
is_obsolete: true
replaced_by: GO:0030684

[Term]
id: GO:0030686
name: 90S preribosome
namespace: cellular_component
def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030687
name: preribosome, large subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 66S in Saccharomyces.
synonym: "66S preribosome" NARROW []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030688
name: preribosome, small subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 43S in Saccharomyces.
synonym: "43S preribosome" NARROW []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030689
name: Noc complex
namespace: cellular_component
def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found.
subset: goslim_pir
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0030690
name: Noc1p-Noc2p complex
namespace: cellular_component
def: "A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030687 ! preribosome, large subunit precursor

[Term]
id: GO:0030691
name: Noc2p-Noc3p complex
namespace: cellular_component
def: "A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
relationship: part_of GO:0030687 ! preribosome, large subunit precursor

[Term]
id: GO:0030692
name: Noc4p-Nop14p complex
namespace: cellular_component
def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654' and/or 'nuclear pore ; GO:0005643'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Nop7 complex" EXACT [GOC:jh, GOC:mah]
synonym: "Nop7 subcomplex" EXACT [GOC:jh, GOC:mah, PMID:18448671]
is_a: GO:0030689 ! Noc complex
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030688 ! preribosome, small subunit precursor

[Term]
id: GO:0030693
name: obsolete caspase activity
namespace: molecular_function
alt_id: GO:0004199
def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase activity" EXACT []
synonym: "caspase-1 activity" NARROW []
synonym: "caspase-10 activity" NARROW []
synonym: "caspase-2 activity" NARROW []
synonym: "caspase-3 activity" NARROW []
synonym: "caspase-4 activity" NARROW []
synonym: "caspase-5 activity" NARROW []
synonym: "caspase-6 activity" NARROW []
synonym: "caspase-7 activity" NARROW []
synonym: "caspase-8 activity" NARROW []
synonym: "caspase-9 activity" NARROW []
synonym: "effector caspase activity" NARROW []
synonym: "signaling (initiator) caspase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0030694
name: bacterial-type flagellum basal body, rod
namespace: cellular_component
def: "The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
synonym: "flagellar basal body, rod" EXACT []
synonym: "flagellin-based flagellum basal body, rod" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0030695
name: GTPase regulator activity
namespace: molecular_function
alt_id: GO:0005083
def: "Binds to and modulates the activity of a GTPase." [GOC:mah]
synonym: "small GTPase regulator activity" RELATED []
synonym: "small GTPase regulatory/interacting protein activity" RELATED []
is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity

[Term]
id: GO:0030696
name: obsolete tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337]
comment: This term was obsoleted because it is an unnecessary grouing class.
synonym: "RUMT" EXACT []
is_obsolete: true
consider: GO:0030697
consider: GO:0047151

[Term]
id: GO:0030697
name: tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent
namespace: molecular_function
alt_id: GO:0009021
def: "Catalysis of the reaction: S-adenosyl-L-methionine + uridine54 in tRNA = 5-methyluridine54 in tRNA + H+ + S-adenosyl-L-homocysteine." [RHEA:42712]
synonym: "M5U-methyltransferase activity" RELATED [EC:2.1.1.35]
synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35]
synonym: "RUMT" BROAD []
synonym: "RUMT activity" RELATED [EC:2.1.1.35]
synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" RELATED [EC:2.1.1.35]
synonym: "S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity" EXACT []
synonym: "transfer RNA uracil 5-methyltransferase activity" RELATED [EC:2.1.1.35]
synonym: "transfer RNA uracil methylase activity" RELATED [EC:2.1.1.35]
synonym: "tRNA (uracil(54)-C(5))-methyltransferase activity, S-adenosyl methionine-dependent" EXACT []
synonym: "tRNA (uracil-5-)-methyltransferase activity" BROAD []
synonym: "tRNA uracil 5-methyltransferase activity" RELATED [EC:2.1.1.35]
synonym: "tRNA:m(5)U54-methyltransferase activity" RELATED [EC:2.1.1.35]
synonym: "tRNA:m5U54-methyltransferase activity" RELATED [EC:2.1.1.35]
xref: EC:2.1.1.35
xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN
xref: RHEA:42712
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity

[Term]
id: GO:0030698
name: obsolete 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria." [GOC:hjd, ISBN:1555811337]
comment: This term was obsoleted because it represents the same activity as tRNA (uracil(54)-C(5))-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent ; GO:0047151.
synonym: "RUMT" BROAD []
is_obsolete: true
replaced_by: GO:0047151

[Term]
id: GO:0030699
name: glycine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + H2O + NH4 + thioredoxin disulfide = glycine + H+ + phosphate + thioredoxin." [EC:1.21.4.2, RHEA:12232]
synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" RELATED [EC:1.21.4.2]
xref: EC:1.21.4.2
xref: KEGG_REACTION:R07226
xref: MetaCyc:RXN-7566
xref: RHEA:12232
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0030700
name: glycine reductase complex
namespace: cellular_component
def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'.
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0030701
name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37]
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37]
synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" RELATED [EC:2.4.2.37]
synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" RELATED [EC:2.4.2.37]
synonym: "NAD-azoferredoxin (ADPribose)transferase activity" RELATED [EC:2.4.2.37]
synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.37
xref: MetaCyc:2.4.2.37-RXN
xref: RHEA:18077
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0030703
name: eggshell formation
namespace: biological_process
def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030704
name: vitelline membrane formation
namespace: biological_process
def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0035803 ! egg coat formation
is_a: GO:0085029 ! extracellular matrix assembly

[Term]
id: GO:0030705
name: cytoskeleton-dependent intracellular transport
namespace: biological_process
def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0030706
name: germarium-derived oocyte differentiation
namespace: biological_process
def: "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte cell differentiation" RELATED []
is_a: GO:0009994 ! oocyte differentiation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030707
name: follicle cell of egg chamber development
namespace: biological_process
def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
is_a: GO:0002064 ! epithelial cell development
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030708
name: germarium-derived female germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]
is_a: GO:0048139 ! female germ-line cyst encapsulation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0030709
name: border follicle cell delamination
namespace: biological_process
def: "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261]
synonym: "border cell delamination" BROAD []
is_a: GO:0060232 ! delamination
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0030710
name: regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "regulation of border cell delamination" BROAD []
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030711
name: positive regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "activation of border follicle cell delamination" NARROW []
synonym: "positive regulation of border cell delamination" BROAD []
synonym: "stimulation of border follicle cell delamination" NARROW []
synonym: "up regulation of border follicle cell delamination" EXACT []
synonym: "up-regulation of border follicle cell delamination" EXACT []
synonym: "upregulation of border follicle cell delamination" EXACT []
is_a: GO:0030710 ! regulation of border follicle cell delamination
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030712
name: negative regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "down regulation of border follicle cell delamination" EXACT []
synonym: "down-regulation of border follicle cell delamination" EXACT []
synonym: "downregulation of border follicle cell delamination" EXACT []
synonym: "inhibition of border follicle cell delamination" NARROW []
synonym: "negative regulation of border cell delamination" BROAD []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0030710 ! regulation of border follicle cell delamination
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030713
name: follicle cell of egg chamber stalk formation
namespace: biological_process
def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0030714
name: anterior/posterior axis specification, follicular epithelium
namespace: biological_process
def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf]
synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009798 ! axis specification
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium
relationship: part_of GO:0030707 ! follicle cell of egg chamber development

[Term]
id: GO:0030715
name: oocyte growth in germarium-derived egg chamber
namespace: biological_process
def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0001555 ! oocyte growth
relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber

[Term]
id: GO:0030716
name: oocyte fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "oocyte cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination

[Term]
id: GO:0030717
name: oocyte karyosome formation
namespace: biological_process
def: "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
is_a: GO:0061988 ! karyosome formation
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030718
name: germ-line stem cell population maintenance
namespace: biological_process
def: "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
is_a: GO:0019827 ! stem cell population maintenance

[Term]
id: GO:0030719
name: P granule organization
namespace: biological_process
alt_id: GO:0048114
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]
synonym: "P granule organization and biogenesis" RELATED []
synonym: "polar granule organisation" EXACT []
synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0030720
name: oocyte localization involved in germarium-derived egg chamber formation
namespace: biological_process
def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT []
synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT []
synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah]
synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte localization during oogenesis" RELATED []
synonym: "oocyte positioning during oogenesis" NARROW []
synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT []
synonym: "oogenesis, oocyte localization" EXACT []
is_a: GO:0051674 ! localization of cell
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030721
name: spectrosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529]
synonym: "spectrosome organisation" EXACT []
synonym: "spectrosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0030723
name: ovarian fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "ovarian fusome organisation" EXACT []
synonym: "ovarian fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045478 ! fusome organization
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030724
name: testicular fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "testicular fusome organisation" EXACT []
synonym: "testicular fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045478 ! fusome organization
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0030725
name: germline ring canal formation
namespace: biological_process
def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238]
synonym: "ring canal formation" BROAD []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0043063 ! intercellular bridge organization

[Term]
id: GO:0030726
name: male germline ring canal formation
namespace: biological_process
def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238]
synonym: "spermatocyte ring canal formation" NARROW []
synonym: "testicular ring canal formation" NARROW []
is_a: GO:0030725 ! germline ring canal formation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0030727
name: germarium-derived female germ-line cyst formation
namespace: biological_process
def: "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
synonym: "germarium-derived female germline cyst formation" EXACT []
is_a: GO:0048135 ! female germ-line cyst formation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030728
name: ovulation
namespace: biological_process
def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437]
xref: Wikipedia:Ovulation
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0030729
name: acetoacetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+." [EC:6.2.1.16, RHEA:16117]
synonym: "acetoacetate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.16]
synonym: "acetoacetyl-CoA synthetase activity" EXACT []
xref: EC:6.2.1.16
xref: KEGG_REACTION:R01357
xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN
xref: Reactome:R-HSA-5694494 "AACS ligates CoA-SH to ACA, forming ACA-CoA"
xref: RHEA:16117
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0030730
name: triglyceride storage
namespace: biological_process
def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732]
synonym: "retention of triacylglycerol" EXACT []
synonym: "retention of triglyceride" EXACT []
synonym: "sequestering of triacylglycerol" EXACT []
synonym: "sequestering of triglyceride" EXACT []
synonym: "sequestration of triacylglycerol" EXACT []
synonym: "sequestration of triglyceride" EXACT []
synonym: "storage of triacylglycerol" EXACT []
synonym: "storage of triglyceride" EXACT []
synonym: "triacylglycerol retention" EXACT []
synonym: "triacylglycerol sequestering" EXACT []
synonym: "triacylglycerol sequestration" EXACT []
synonym: "triacylglycerol storage" EXACT []
synonym: "triglyceride retention" EXACT []
synonym: "triglyceride sequestering" EXACT []
synonym: "triglyceride sequestration" EXACT []
is_a: GO:0019915 ! lipid storage

[Term]
id: GO:0030731
name: guanidinoacetate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+." [EC:2.1.1.2, RHEA:10656]
synonym: "GA methylpherase activity" RELATED [EC:2.1.1.2]
synonym: "guanidinoacetate methyltransferase activity" RELATED [EC:2.1.1.2]
synonym: "guanidinoacetate transmethylase activity" RELATED [EC:2.1.1.2]
synonym: "guanidoacetate methyltransferase activity" RELATED [EC:2.1.1.2]
synonym: "methionine-guanidinoacetic transmethylase activity" RELATED [EC:2.1.1.2]
synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" RELATED [EC:2.1.1.2]
xref: EC:2.1.1.2
xref: KEGG_REACTION:R01883
xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN
xref: RHEA:10656
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030732
name: methionine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12]
synonym: "methionine methyltransferase activity" RELATED [EC:2.1.1.12]
synonym: "S-adenosyl methionine:methionine methyl transferase activity" RELATED [EC:2.1.1.12]
synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" RELATED [EC:2.1.1.12]
synonym: "S-adenosylmethionine transmethylase activity" RELATED [EC:2.1.1.12]
synonym: "S-adenosylmethionine-methionine methyltransferase activity" RELATED [EC:2.1.1.12]
xref: EC:2.1.1.12
xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN
xref: RHEA:13761
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030733
name: fatty acid O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15]
synonym: "fatty acid methyltransferase activity" RELATED [EC:2.1.1.15]
synonym: "fatty-acid O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" RELATED [EC:2.1.1.15]
xref: EC:2.1.1.15
xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN
xref: RHEA:23012
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030734
name: polysaccharide O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18]
synonym: "acylpolysacharide 6-methyltransferase activity" RELATED [EC:2.1.1.18]
synonym: "polysaccharide methyltransferase activity" RELATED [EC:2.1.1.18]
synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" RELATED [EC:2.1.1.18]
xref: EC:2.1.1.18
xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030735
name: carnosine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H+." [EC:2.1.1.22, RHEA:14205]
synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" RELATED [EC:2.1.1.22]
xref: EC:2.1.1.22
xref: KEGG_REACTION:R02144
xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-8876789 "CARNMT1 methylates CARN to Anserine"
xref: RHEA:14205
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030736
name: phenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H+." [EC:2.1.1.25, RHEA:14809]
synonym: "PMT" RELATED [EC:2.1.1.25]
synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" RELATED [EC:2.1.1.25]
xref: EC:2.1.1.25
xref: KEGG_REACTION:R01239
xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN
xref: RHEA:14809
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030737
name: iodophenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.26, RHEA:14313]
synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" RELATED [EC:2.1.1.26]
xref: EC:2.1.1.26
xref: KEGG_REACTION:R03746
xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN
xref: RHEA:14313
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030738
name: tyramine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.27, RHEA:14865]
synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" RELATED [EC:2.1.1.27]
synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" RELATED [EC:2.1.1.27]
synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" RELATED [EC:2.1.1.27]
synonym: "tyramine methylpherase activity" RELATED [EC:2.1.1.27]
xref: EC:2.1.1.27
xref: KEGG_REACTION:R02384
xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN
xref: RHEA:14865
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030739
name: O-demethylpuromycin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38]
synonym: "O-demethylpuromycin methyltransferase activity" RELATED [EC:2.1.1.38]
synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" RELATED [EC:2.1.1.38]
xref: EC:2.1.1.38
xref: MetaCyc:2.1.1.38-RXN
xref: RHEA:22280
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030740
name: inositol 3-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.39, RHEA:18877]
synonym: "inositol L-1-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" RELATED [EC:2.1.1.39]
synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39]
xref: EC:2.1.1.39
xref: KEGG_REACTION:R01189
xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN
xref: RHEA:18877
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030741
name: inositol 1-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.40, RHEA:17565]
synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" RELATED [EC:2.1.1.40]
synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "inositol D-1-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40]
xref: EC:2.1.1.40
xref: KEGG_REACTION:R01188
xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN
xref: RHEA:17565
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030742
name: GTP-dependent protein binding
namespace: molecular_function
def: "Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state." [GOC:go_curators, GOC:krc]
comment: This term may be used to annotate both partners in a GTP-dependent binding interaction, both the GTP-bound protein and the protein(s) which interact with it.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030743
name: 23S rRNA (adenosine(1067)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H+ + S-adenosyl-L-homocysteine." [EC:2.1.1.230]
synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" RELATED [EC:2.1.1.230]
synonym: "RNA-pentose methylase activity" RELATED []
synonym: "rRNA adenosine 2'-methylase activity" RELATED [EC:2.1.1.230]
synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" RELATED [EC:2.1.1.230]
synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.230]
xref: EC:2.1.1.230
xref: MetaCyc:RXN-12464
xref: RHEA:43212
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity
is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity

[Term]
id: GO:0030744
name: obsolete luteolin O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H+." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of flavone 3'-O-methyltransferase activity ; GO:0102822.
is_obsolete: true
replaced_by: GO:0102822

[Term]
id: GO:0030745
name: obsolete dimethylhistidine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [GOC:curators]
comment: This term was obsoleted because it represents a substep of L-histidine N(alpha)-methyltransferase activity ; GO:0052706.
is_obsolete: true
replaced_by: GO:0052706

[Term]
id: GO:0030746
name: isoflavone 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46]
synonym: "4'-hydroxyisoflavone methyltransferase activity" RELATED [EC:2.1.1.46]
synonym: "isoflavone methyltransferase activity" RELATED [EC:2.1.1.46]
synonym: "isoflavone O-methyltransferase activity" RELATED [EC:2.1.1.46]
synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.46]
xref: EC:2.1.1.46
xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN
xref: RHEA:31739
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030747
name: indolepyruvate C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H+ + S-adenosyl-L-homocysteine." [EC:2.1.1.47]
synonym: "indolepyruvate 3-methyltransferase activity" RELATED [EC:2.1.1.47]
synonym: "indolepyruvate methyltransferase activity" RELATED [EC:2.1.1.47]
synonym: "indolepyruvic acid methyltransferase activity" RELATED [EC:2.1.1.47]
synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" RELATED [EC:2.1.1.47]
synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" RELATED [EC:2.1.1.47]
xref: EC:2.1.1.47
xref: MetaCyc:RXN-17530
xref: RHEA:12112
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030748
name: amine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. Acts on primary, secondary and tertiary amines." [EC:2.1.1.49]
synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49]
synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49]
synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" RELATED [EC:2.1.1.49]
synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49]
synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49]
xref: EC:2.1.1.49
xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030749
name: loganate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50]
synonym: "loganate methyltransferase activity" RELATED [EC:2.1.1.50]
synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" RELATED [EC:2.1.1.50]
synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" RELATED [EC:2.1.1.50]
xref: EC:2.1.1.50
xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN
xref: RHEA:12508
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030750
name: putrescine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.53, RHEA:15037]
synonym: "putrescine methyltransferase activity" RELATED [EC:2.1.1.53]
synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" RELATED [EC:2.1.1.53]
xref: EC:2.1.1.53
xref: KEGG_REACTION:R01153
xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN
xref: RHEA:15037
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030751
name: licodione 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.65, RHEA:18521]
synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" RELATED [EC:2.1.1.65]
xref: EC:2.1.1.65
xref: KEGG_REACTION:R03623
xref: MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN
xref: RHEA:18521
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030752
name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0030764
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69]
synonym: "bergaptol 5-O-methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "bergaptol methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "bergaptol O-methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "BMT activity" RELATED [EC:2.1.1.69]
synonym: "furanocoumarin 5-methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "furanocoumarin 5-O-methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" RELATED [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" RELATED [EC:2.1.1.69]
xref: EC:2.1.1.69
xref: MetaCyc:2.1.1.69-RXN
xref: RHEA:11808
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030753
name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0030765
def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin." [EC:2.1.1.70]
synonym: "furanocoumarin 8-methyltransferase activity" RELATED [EC:2.1.1.70]
synonym: "furanocoumarin 8-O-methyl-transferase activity" RELATED [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" RELATED [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" RELATED [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" RELATED [EC:2.1.1.70]
synonym: "xanthotoxol 8-O-methyltransferase activity" RELATED [EC:2.1.1.70]
synonym: "xanthotoxol methyltransferase activity" RELATED [EC:2.1.1.70]
synonym: "xanthotoxol O-methyltransferase activity" EXACT []
synonym: "XMT activity" RELATED [EC:2.1.1.70]
xref: EC:2.1.1.70
xref: KEGG_REACTION:R02982
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030754
name: apigenin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75]
synonym: "flavonoid methyltransferase activity" RELATED [EC:2.1.1.75]
synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75]
synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.75]
xref: EC:2.1.1.75
xref: MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN
xref: RHEA:20429
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030755
name: quercetin 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76]
synonym: "flavonoid 3-methyltransferase activity" RELATED [EC:2.1.1.76]
synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76]
synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" RELATED [EC:2.1.1.76]
xref: EC:2.1.1.76
xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN
xref: RHEA:17673
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030756
name: isoorientin 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H+ + isoscoparin." [EC:2.1.1.78, RHEA:24096]
synonym: "isoorientin 3'-methyltransferase activity" RELATED [EC:2.1.1.78]
synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" RELATED [EC:2.1.1.78]
xref: EC:2.1.1.78
xref: KEGG_REACTION:R03731
xref: MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN
xref: RHEA:24096
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030757
name: 3-methylquercitin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine." [EC:2.1.1.82, RHEA:16181]
synonym: "3-methylquercetin 7-O-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "7-OMT activity" RELATED [EC:2.1.1.82]
synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" RELATED [EC:2.1.1.82]
xref: EC:2.1.1.82
xref: KEGG_REACTION:R05323
xref: MetaCyc:2.1.1.82-RXN
xref: RHEA:16181
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030758
name: 3,7-dimethylquercitin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.83, RHEA:21832]
synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "4'-OMT activity" RELATED [EC:2.1.1.83]
synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83]
xref: EC:2.1.1.83
xref: KEGG_REACTION:R03456
xref: MetaCyc:2.1.1.83-RXN
xref: RHEA:21832
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030759
name: methylquercetagetin 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.84, RHEA:18717]
synonym: "6-OMT" RELATED [EC:2.1.1.84]
synonym: "flavonol 6-methyltransferase activity" RELATED [EC:2.1.1.84]
synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84]
synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" RELATED [EC:2.1.1.84]
xref: EC:2.1.1.84
xref: KEGG_REACTION:R04505
xref: MetaCyc:2.1.1.84-RXN
xref: RHEA:18717
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030760
name: pyridine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine." [EC:2.1.1.87, RHEA:16893]
synonym: "pyridine methyltransferase activity" RELATED [EC:2.1.1.87]
synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" RELATED [EC:2.1.1.87]
xref: EC:2.1.1.87
xref: KEGG_REACTION:R02862
xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-175987 "NNMT transfers CH3 from AdoMet to PY"
xref: RHEA:16893
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030761
name: 8-hydroxyquercitin 8-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.88, RHEA:16593]
synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" RELATED [EC:2.1.1.88]
synonym: "flavonol 8-methyltransferase activity" RELATED [EC:2.1.1.88]
synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88]
synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" RELATED [EC:2.1.1.88]
xref: EC:2.1.1.88
xref: KEGG_REACTION:R04398
xref: MetaCyc:2.1.1.88-RXN
xref: RHEA:16593
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030762
name: tetrahydrocolumbamine 2-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H+ + tetrahydropalmatine." [EC:2.1.1.89, RHEA:22536]
synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" RELATED [EC:2.1.1.89]
synonym: "tetrahydrocolumbamine methyltransferase activity" RELATED [EC:2.1.1.89]
xref: EC:2.1.1.89
xref: KEGG_REACTION:R04077
xref: MetaCyc:2.1.1.89-RXN
xref: RHEA:22536
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030763
name: isobutyraldoxime O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.91, RHEA:10996]
synonym: "aldoxime methyltransferase activity" RELATED [EC:2.1.1.91]
synonym: "aldoxime O-methyltransferase activity" RELATED [EC:2.1.1.91]
synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" RELATED [EC:2.1.1.91]
synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" RELATED [EC:2.1.1.91]
xref: EC:2.1.1.91
xref: KEGG_REACTION:R04169
xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN
xref: RHEA:10996
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030766
name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94]
synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" RELATED [EC:2.1.1.94]
synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" RELATED [EC:2.1.1.94]
synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" RELATED [EC:2.1.1.94]
synonym: "tabersonine 16-O-methyltransferase activity" RELATED [EC:2.1.1.94]
xref: EC:2.1.1.94
xref: MetaCyc:2.1.1.94-RXN
xref: RHEA:20992
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030767
name: 3-hydroxyanthranilate 4-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.97, RHEA:17833]
synonym: "3-hydroxyanthranilate 4-methyltransferase activity" RELATED [EC:2.1.1.97]
synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" RELATED [EC:2.1.1.97]
xref: EC:2.1.1.97
xref: KEGG_REACTION:R02667
xref: MetaCyc:2.1.1.97-RXN
xref: RHEA:17833
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030768
name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H+." [EC:2.1.1.99, RHEA:11336]
synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" RELATED [EC:2.1.1.99]
synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" RELATED [EC:2.1.1.99]
synonym: "NMT activity" RELATED [EC:2.1.1.99]
synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" RELATED [EC:2.1.1.99]
synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" RELATED [EC:2.1.1.99]
xref: EC:2.1.1.99
xref: KEGG_REACTION:R04013
xref: MetaCyc:2.1.1.99-RXN
xref: RHEA:11336
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030769
name: macrocin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H+ + tylosin." [EC:2.1.1.101, RHEA:17269]
synonym: "macrocin methyltransferase activity" RELATED [EC:2.1.1.101]
synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" RELATED [EC:2.1.1.101]
synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" RELATED [EC:2.1.1.101]
xref: EC:2.1.1.101
xref: KEGG_REACTION:R02858
xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:17269
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030770
name: demethylmacrocin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H+ + macrocin." [EC:2.1.1.102, RHEA:17573]
synonym: "demethylmacrocin methyltransferase activity" RELATED [EC:2.1.1.102]
synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" RELATED [EC:2.1.1.102]
xref: EC:2.1.1.102
xref: KEGG_REACTION:R02859
xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:17573
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030771
name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.105, RHEA:17405]
synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105]
synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" RELATED [EC:2.1.1.105]
synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" RELATED [EC:2.1.1.105]
xref: EC:2.1.1.105
xref: KEGG_REACTION:R04421
xref: MetaCyc:2.1.1.105-RXN
xref: RHEA:17405
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030772
name: tryptophan 2-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H+." [EC:2.1.1.106, RHEA:17321]
synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" RELATED [EC:2.1.1.106]
synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" RELATED [EC:2.1.1.106]
synonym: "tryptophan 2-methyltransferase activity" RELATED [EC:2.1.1.106]
xref: EC:2.1.1.106
xref: KEGG_REACTION:R08547
xref: MetaCyc:RXN-16751
xref: RHEA:17321
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030773
name: 6-hydroxymellein O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.108, RHEA:15201]
synonym: "6-hydroxymellein methyltransferase activity" RELATED [EC:2.1.1.108]
synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" RELATED [EC:2.1.1.108]
xref: EC:2.1.1.108
xref: KEGG_REACTION:R03934
xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:15201
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030774
name: anthranilate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.111, RHEA:12180]
synonym: "anthranilic acid N-methyltransferase activity" RELATED [EC:2.1.1.111]
synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" RELATED [EC:2.1.1.111]
xref: EC:2.1.1.111
xref: KEGG_REACTION:R00984
xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN
xref: RHEA:12180
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030775
name: glucuronoxylan 4-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112]
synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" RELATED [EC:2.1.1.112]
xref: EC:2.1.1.112
xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN
xref: RHEA:20413
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030776
name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115]
synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" RELATED [EC:2.1.1.115]
synonym: "norreticuline N-methyltransferase activity" RELATED [EC:2.1.1.115]
synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" RELATED [EC:2.1.1.115]
xref: EC:2.1.1.115
xref: MetaCyc:2.1.1.115-RXN
xref: RHEA:13005
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030777
name: (S)-scoulerine 9-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.117, RHEA:23808]
synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" RELATED [EC:2.1.1.117]
synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" RELATED [EC:2.1.1.117]
xref: EC:2.1.1.117
xref: KEGG_REACTION:R03835
xref: MetaCyc:2.1.1.117-RXN
xref: RHEA:23808
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030778
name: columbamine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H+ + palmatine." [EC:2.1.1.118, RHEA:15373]
synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" RELATED [EC:2.1.1.118]
xref: EC:2.1.1.118
xref: KEGG_REACTION:R03721
xref: MetaCyc:2.1.1.118-RXN
xref: RHEA:15373
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030779
name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H+." [EC:2.1.1.119, RHEA:18541]
synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" RELATED [EC:2.1.1.119]
xref: EC:2.1.1.119
xref: KEGG_REACTION:R04707
xref: MetaCyc:2.1.1.119-RXN
xref: RHEA:18541
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030780
name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H+." [EC:2.1.1.120, RHEA:21092]
synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" RELATED [EC:2.1.1.120]
xref: EC:2.1.1.120
xref: KEGG_REACTION:R04705
xref: MetaCyc:2.1.1.120-RXN
xref: RHEA:21092
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030781
name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121]
synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" RELATED [EC:2.1.1.121]
xref: EC:2.1.1.121
xref: MetaCyc:2.1.1.121-RXN
xref: RHEA:11892
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030782
name: (S)-tetrahydroprotoberberine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122]
synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" RELATED [EC:2.1.1.122]
synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" RELATED [EC:2.1.1.122]
xref: EC:2.1.1.122
xref: MetaCyc:2.1.1.122-RXN
xref: RHEA:12805
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030783
name: [cytochrome c]-methionine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123]
synonym: "cytochrome c-methionine S-methyltransferase activity" RELATED [EC:2.1.1.123]
synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" RELATED [EC:2.1.1.123]
xref: EC:2.1.1.123
xref: MetaCyc:2.1.1.123-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030784
name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116]
synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" RELATED [EC:2.1.1.116]
xref: EC:2.1.1.116
xref: MetaCyc:2.1.1.116-RXN
xref: RHEA:17789
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030785
name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127]
synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" RELATED [EC:2.1.1.127]
synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" RELATED [EC:2.1.1.127]
synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" RELATED [EC:2.1.1.127]
synonym: "RuBisCO LSMT activity" RELATED [EC:2.1.1.127]
synonym: "RuBisCO methyltransferase activity" RELATED [EC:2.1.1.127]
synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" RELATED [EC:2.1.1.127]
synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" RELATED [EC:2.1.1.127]
xref: EC:2.1.1.127
xref: MetaCyc:2.1.1.127-RXN
xref: RHEA:50996
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030786
name: (RS)-norcoclaurine 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128]
synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" RELATED [EC:2.1.1.128]
xref: EC:2.1.1.128
xref: MetaCyc:2.1.1.128-RXN
xref: RHEA:19941
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030787
name: inositol 4-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.129, RHEA:23248]
synonym: "myo-inositol 4-O-methyltransferase activity" RELATED [EC:2.1.1.129]
synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" RELATED [EC:2.1.1.129]
synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" RELATED [EC:2.1.1.129]
xref: EC:2.1.1.129
xref: KEGG_REACTION:R01190
xref: MetaCyc:2.1.1.129-RXN
xref: RHEA:23248
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030788
name: precorrin-2 C20-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A." [EC:2.1.1.130, RHEA:16841]
synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" RELATED [EC:2.1.1.130]
synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" RELATED [EC:2.1.1.130]
xref: EC:2.1.1.130
xref: KEGG_REACTION:R03948
xref: MetaCyc:2.1.1.130-RXN
xref: RHEA:16841
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030789
name: precorrin-3B C17-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131]
synonym: "CobJ" RELATED [EC:2.1.1.131]
synonym: "precorrin-3 methylase activity" RELATED [EC:2.1.1.131]
synonym: "precorrin-3 methyltransferase activity" RELATED [EC:2.1.1.131]
synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" RELATED [EC:2.1.1.131]
xref: EC:2.1.1.131
xref: MetaCyc:2.1.1.131-RXN
xref: RHEA:12761
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030790
name: chlorophenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136]
synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136]
synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" RELATED [EC:2.1.1.136]
synonym: "trichlorophenol O-methyltransferase activity" RELATED [EC:2.1.1.136]
xref: EC:2.1.1.136
xref: MetaCyc:2.1.1.136-RXN
xref: RHEA:18909
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030791
name: arsenite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137]
comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792).
synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" RELATED [EC:2.1.1.137]
synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" RELATED [EC:2.1.1.137]
synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" RELATED [EC:2.1.1.137]
xref: EC:2.1.1.137
xref: Reactome:R-HSA-5696213 "AS3MT transfers CH3 from AdoMet to methylarsonite"
xref: Reactome:R-HSA-5696220 "AS3MT transfers CH3 from AdoMet to arsenite(3-)"
xref: UM-BBD_reactionID:r0805
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030792
name: obsolete methylarsonite methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [GOC:curators]
comment: This term was obsoleted because the corresponding EC, EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137).
is_obsolete: true
replaced_by: GO:0030791

[Term]
id: GO:0030793
name: 3'-demethylstaurosporine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H+ + staurosporine." [EC:2.1.1.139, RHEA:11696]
synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" RELATED [EC:2.1.1.139]
synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" RELATED [EC:2.1.1.139]
synonym: "staurosporine synthase activity" RELATED [EC:2.1.1.139]
xref: EC:2.1.1.139
xref: KEGG_REACTION:R05757
xref: MetaCyc:2.1.1.139-RXN
xref: RHEA:11696
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030794
name: (S)-coclaurine-N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140]
synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" RELATED [EC:2.1.1.140]
xref: EC:2.1.1.140
xref: MetaCyc:2.1.1.140-RXN
xref: RHEA:17409
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030795
name: methyl jasmonate methylesterase activity
namespace: molecular_function
alt_id: GO:0045546
alt_id: GO:0102078
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate." [RHEA:13349]
synonym: "jasmonic acid carboxyl methyltransferase activity" RELATED [EC:2.1.1.141]
synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" RELATED [EC:2.1.1.141]
synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT []
xref: EC:2.1.1.141
xref: MetaCyc:RXN-10768
xref: RHEA:13349
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030796
name: cycloartenol 24-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.142, RHEA:13137]
synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" RELATED [EC:2.1.1.142]
synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142]
xref: EC:2.1.1.142
xref: KEGG_REACTION:R05760
xref: MetaCyc:2.1.1.142-RXN
xref: RHEA:13137
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030797
name: 24-methylenesterol C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.143, RHEA:21044]
synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" RELATED [EC:2.1.1.143]
synonym: "24-methylenelophenol C-241-methyltransferase activity" RELATED [EC:2.1.1.143]
synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" RELATED [EC:2.1.1.143]
synonym: "SMT(2) activity" NARROW [EC:2.1.1.143]
synonym: "SMT2" RELATED [EC:2.1.1.143]
xref: EC:2.1.1.143
xref: KEGG_REACTION:R05776
xref: MetaCyc:2.1.1.143-RXN
xref: RHEA:21044
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030798
name: trans-aconitate 2-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14969]
synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" RELATED [EC:2.1.1.144]
xref: EC:2.1.1.144
xref: KEGG_REACTION:R05763
xref: MetaCyc:RXN0-2441
xref: RHEA:14969
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030799
name: obsolete regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "regulation of cyclic nucleotide metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030800
name: obsolete negative regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "down regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "downregulation of cyclic nucleotide metabolic process" EXACT []
synonym: "inhibition of cyclic nucleotide metabolic process" NARROW []
synonym: "negative regulation of cyclic nucleotide metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030801
name: obsolete positive regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cyclic nucleotide metabolic process" NARROW []
synonym: "positive regulation of cyclic nucleotide metabolism" EXACT []
synonym: "stimulation of cyclic nucleotide metabolic process" NARROW []
synonym: "up regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "upregulation of cyclic nucleotide metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030802
name: obsolete regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "regulation of cyclic nucleotide anabolism" EXACT []
synonym: "regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "regulation of cyclic nucleotide formation" EXACT []
synonym: "regulation of cyclic nucleotide synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0030803
name: obsolete negative regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW []
synonym: "negative regulation of cyclic nucleotide anabolism" EXACT []
synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "negative regulation of cyclic nucleotide formation" EXACT []
synonym: "negative regulation of cyclic nucleotide synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0030804
name: obsolete positive regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cyclic nucleotide biosynthetic process" NARROW []
synonym: "positive regulation of cyclic nucleotide anabolism" EXACT []
synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "positive regulation of cyclic nucleotide formation" EXACT []
synonym: "positive regulation of cyclic nucleotide synthesis" EXACT []
synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW []
synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030805
name: regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
synonym: "regulation of cyclic nucleotide breakdown" EXACT []
synonym: "regulation of cyclic nucleotide catabolism" EXACT []
synonym: "regulation of cyclic nucleotide degradation" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process

[Term]
id: GO:0030806
name: obsolete negative regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "down regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "downregulation of cyclic nucleotide catabolic process" EXACT []
synonym: "inhibition of cyclic nucleotide catabolic process" NARROW []
synonym: "negative regulation of cyclic nucleotide breakdown" EXACT []
synonym: "negative regulation of cyclic nucleotide catabolism" EXACT []
synonym: "negative regulation of cyclic nucleotide degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0030807
name: obsolete positive regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cyclic nucleotide catabolic process" NARROW []
synonym: "positive regulation of cyclic nucleotide breakdown" EXACT []
synonym: "positive regulation of cyclic nucleotide catabolism" EXACT []
synonym: "positive regulation of cyclic nucleotide degradation" EXACT []
synonym: "stimulation of cyclic nucleotide catabolic process" NARROW []
synonym: "up regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "upregulation of cyclic nucleotide catabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030808
name: regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
synonym: "regulation of nucleotide anabolism" EXACT []
synonym: "regulation of nucleotide biosynthesis" EXACT []
synonym: "regulation of nucleotide formation" EXACT []
synonym: "regulation of nucleotide synthesis" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030809
name: negative regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
synonym: "down regulation of nucleotide biosynthetic process" EXACT []
synonym: "down-regulation of nucleotide biosynthetic process" EXACT []
synonym: "downregulation of nucleotide biosynthetic process" EXACT []
synonym: "inhibition of nucleotide biosynthetic process" NARROW []
synonym: "negative regulation of nucleotide anabolism" EXACT []
synonym: "negative regulation of nucleotide biosynthesis" EXACT []
synonym: "negative regulation of nucleotide formation" EXACT []
synonym: "negative regulation of nucleotide synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030810
name: positive regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
synonym: "activation of nucleotide biosynthetic process" NARROW []
synonym: "positive regulation of nucleotide anabolism" EXACT []
synonym: "positive regulation of nucleotide biosynthesis" EXACT []
synonym: "positive regulation of nucleotide formation" EXACT []
synonym: "positive regulation of nucleotide synthesis" EXACT []
synonym: "stimulation of nucleotide biosynthetic process" NARROW []
synonym: "up regulation of nucleotide biosynthetic process" EXACT []
synonym: "up-regulation of nucleotide biosynthetic process" EXACT []
synonym: "upregulation of nucleotide biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030811
name: regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
synonym: "regulation of nucleotide breakdown" EXACT []
synonym: "regulation of nucleotide catabolism" EXACT []
synonym: "regulation of nucleotide degradation" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0009894 ! regulation of catabolic process
relationship: regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030812
name: negative regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
synonym: "down regulation of nucleotide catabolic process" EXACT []
synonym: "down-regulation of nucleotide catabolic process" EXACT []
synonym: "downregulation of nucleotide catabolic process" EXACT []
synonym: "inhibition of nucleotide catabolic process" NARROW []
synonym: "negative regulation of nucleotide breakdown" EXACT []
synonym: "negative regulation of nucleotide catabolism" EXACT []
synonym: "negative regulation of nucleotide degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030813
name: positive regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
synonym: "activation of nucleotide catabolic process" NARROW []
synonym: "positive regulation of nucleotide breakdown" EXACT []
synonym: "positive regulation of nucleotide catabolism" EXACT []
synonym: "positive regulation of nucleotide degradation" EXACT []
synonym: "stimulation of nucleotide catabolic process" NARROW []
synonym: "up regulation of nucleotide catabolic process" EXACT []
synonym: "up-regulation of nucleotide catabolic process" EXACT []
synonym: "upregulation of nucleotide catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
relationship: positively_regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030814
name: obsolete regulation of cAMP metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "regulation of 3',5' cAMP metabolism" EXACT []
synonym: "regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "regulation of cAMP metabolism" EXACT []
synonym: "regulation of cyclic AMP metabolic process" EXACT []
synonym: "regulation of cyclic AMP metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030815
name: obsolete negative regulation of cAMP metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "down regulation of cAMP metabolic process" EXACT []
synonym: "down-regulation of cAMP metabolic process" EXACT []
synonym: "downregulation of cAMP metabolic process" EXACT []
synonym: "inhibition of cAMP metabolic process" NARROW []
synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "negative regulation of 3',5' cAMP metabolism" EXACT []
synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "negative regulation of cAMP metabolism" EXACT []
synonym: "negative regulation of cyclic AMP metabolic process" EXACT []
synonym: "negative regulation of cyclic AMP metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030816
name: obsolete positive regulation of cAMP metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cAMP metabolic process" NARROW []
synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "positive regulation of 3',5' cAMP metabolism" EXACT []
synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "positive regulation of cAMP metabolism" EXACT []
synonym: "positive regulation of cyclic AMP metabolic process" EXACT []
synonym: "positive regulation of cyclic AMP metabolism" EXACT []
synonym: "stimulation of cAMP metabolic process" NARROW []
synonym: "up regulation of cAMP metabolic process" EXACT []
synonym: "up-regulation of cAMP metabolic process" EXACT []
synonym: "upregulation of cAMP metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030817
name: obsolete regulation of cAMP biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "regulation of cAMP anabolism" EXACT []
synonym: "regulation of cAMP biosynthesis" EXACT []
synonym: "regulation of cAMP formation" EXACT []
synonym: "regulation of cAMP synthesis" EXACT []
synonym: "regulation of cyclic AMP biosynthesis" EXACT []
synonym: "regulation of cyclic AMP biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030818
name: obsolete negative regulation of cAMP biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: The reason for obsoletion is that the term represents a molecular function.
synonym: "down regulation of cAMP biosynthetic process" EXACT []
synonym: "down-regulation of cAMP biosynthetic process" EXACT []
synonym: "downregulation of cAMP biosynthetic process" EXACT []
synonym: "inhibition of cAMP biosynthetic process" NARROW []
synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "negative regulation of cAMP anabolism" EXACT []
synonym: "negative regulation of cAMP biosynthesis" EXACT []
synonym: "negative regulation of cAMP formation" EXACT []
synonym: "negative regulation of cAMP synthesis" EXACT []
synonym: "negative regulation of cyclic AMP biosynthesis" EXACT []
synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030819
name: obsolete positive regulation of cAMP biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
synonym: "activation of cAMP biosynthetic process" NARROW []
synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "positive regulation of cAMP anabolism" EXACT []
synonym: "positive regulation of cAMP biosynthesis" EXACT []
synonym: "positive regulation of cAMP formation" EXACT []
synonym: "positive regulation of cAMP synthesis" EXACT []
synonym: "positive regulation of cyclic AMP biosynthesis" EXACT []
synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT []
synonym: "stimulation of cAMP biosynthetic process" NARROW []
synonym: "up regulation of cAMP biosynthetic process" EXACT []
synonym: "up-regulation of cAMP biosynthetic process" EXACT []
synonym: "upregulation of cAMP biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030820
name: obsolete regulation of cAMP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "regulation of 3',5' cAMP catabolism" EXACT []
synonym: "regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "regulation of cAMP breakdown" EXACT []
synonym: "regulation of cAMP catabolism" EXACT []
synonym: "regulation of cAMP degradation" EXACT []
synonym: "regulation of cyclic AMP catabolic process" EXACT []
synonym: "regulation of cyclic AMP catabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030821
name: obsolete negative regulation of cAMP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "down regulation of cAMP catabolic process" EXACT []
synonym: "down-regulation of cAMP catabolic process" EXACT []
synonym: "downregulation of cAMP catabolic process" EXACT []
synonym: "inhibition of cAMP catabolic process" NARROW []
synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "negative regulation of 3',5' cAMP catabolism" EXACT []
synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "negative regulation of cAMP breakdown" EXACT []
synonym: "negative regulation of cAMP catabolism" EXACT []
synonym: "negative regulation of cAMP degradation" EXACT []
synonym: "negative regulation of cyclic AMP catabolic process" EXACT []
synonym: "negative regulation of cyclic AMP catabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030822
name: obsolete positive regulation of cAMP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cAMP catabolic process" NARROW []
synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "positive regulation of 3',5' cAMP catabolism" EXACT []
synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "positive regulation of cAMP breakdown" EXACT []
synonym: "positive regulation of cAMP catabolism" EXACT []
synonym: "positive regulation of cAMP degradation" EXACT []
synonym: "positive regulation of cyclic AMP catabolic process" EXACT []
synonym: "positive regulation of cyclic AMP catabolism" EXACT []
synonym: "stimulation of cAMP catabolic process" NARROW []
synonym: "up regulation of cAMP catabolic process" EXACT []
synonym: "up-regulation of cAMP catabolic process" EXACT []
synonym: "upregulation of cAMP catabolic process" EXACT []
is_obsolete: true
consider: GO:0071878

[Term]
id: GO:0030823
name: obsolete regulation of cGMP metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "regulation of cGMP metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030824
name: obsolete negative regulation of cGMP metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism.
synonym: "down regulation of cGMP metabolic process" EXACT []
synonym: "down-regulation of cGMP metabolic process" EXACT []
synonym: "downregulation of cGMP metabolic process" EXACT []
synonym: "inhibition of cGMP metabolic process" NARROW []
synonym: "negative regulation of cGMP metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0030825
name: obsolete positive regulation of cGMP metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cGMP metabolic process" NARROW []
synonym: "positive regulation of cGMP metabolism" EXACT []
synonym: "stimulation of cGMP metabolic process" NARROW []
synonym: "up regulation of cGMP metabolic process" EXACT []
synonym: "up-regulation of cGMP metabolic process" EXACT []
synonym: "upregulation of cGMP metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030826
name: obsolete regulation of cGMP biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "regulation of cGMP anabolism" EXACT []
synonym: "regulation of cGMP biosynthesis" EXACT []
synonym: "regulation of cGMP formation" EXACT []
synonym: "regulation of cGMP synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0030827
name: obsolete negative regulation of cGMP biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism.
synonym: "down regulation of cGMP biosynthetic process" EXACT []
synonym: "down-regulation of cGMP biosynthetic process" EXACT []
synonym: "downregulation of cGMP biosynthetic process" EXACT []
synonym: "inhibition of cGMP biosynthetic process" NARROW []
synonym: "negative regulation of cGMP anabolism" EXACT []
synonym: "negative regulation of cGMP biosynthesis" EXACT []
synonym: "negative regulation of cGMP formation" EXACT []
synonym: "negative regulation of cGMP synthesis" EXACT []
is_obsolete: true
consider: GO:0030251

[Term]
id: GO:0030828
name: obsolete positive regulation of cGMP biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cGMP biosynthetic process" NARROW []
synonym: "positive regulation of cGMP anabolism" EXACT []
synonym: "positive regulation of cGMP biosynthesis" EXACT []
synonym: "positive regulation of cGMP formation" EXACT []
synonym: "positive regulation of cGMP synthesis" EXACT []
synonym: "stimulation of cGMP biosynthetic process" NARROW []
synonym: "up regulation of cGMP biosynthetic process" EXACT []
synonym: "up-regulation of cGMP biosynthetic process" EXACT []
synonym: "upregulation of cGMP biosynthetic process" EXACT []
is_obsolete: true
consider: GO:0004383

[Term]
id: GO:0030829
name: obsolete regulation of cGMP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism.
synonym: "regulation of cGMP breakdown" EXACT []
synonym: "regulation of cGMP catabolism" EXACT []
synonym: "regulation of cGMP degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0030830
name: obsolete negative regulation of cGMP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism.
synonym: "down regulation of cGMP catabolic process" EXACT []
synonym: "down-regulation of cGMP catabolic process" EXACT []
synonym: "downregulation of cGMP catabolic process" EXACT []
synonym: "inhibition of cGMP catabolic process" NARROW []
synonym: "negative regulation of cGMP breakdown" EXACT []
synonym: "negative regulation of cGMP catabolism" EXACT []
synonym: "negative regulation of cGMP degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0030831
name: obsolete positive regulation of cGMP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
synonym: "activation of cGMP catabolic process" NARROW []
synonym: "positive regulation of cGMP breakdown" EXACT []
synonym: "positive regulation of cGMP catabolism" EXACT []
synonym: "positive regulation of cGMP degradation" EXACT []
synonym: "stimulation of cGMP catabolic process" NARROW []
synonym: "up regulation of cGMP catabolic process" EXACT []
synonym: "up-regulation of cGMP catabolic process" EXACT []
synonym: "upregulation of cGMP catabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0030832
name: regulation of actin filament length
namespace: biological_process
def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0032535 ! regulation of cellular component size
is_a: GO:0032956 ! regulation of actin cytoskeleton organization

[Term]
id: GO:0030833
name: regulation of actin filament polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
synonym: "regulation of actin polymerization" EXACT []
is_a: GO:0008064 ! regulation of actin polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
relationship: regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030834
name: regulation of actin filament depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
synonym: "regulation of actin depolymerization" EXACT []
is_a: GO:0008064 ! regulation of actin polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
relationship: regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030835
name: negative regulation of actin filament depolymerization
namespace: biological_process
alt_id: GO:0030044
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837').
synonym: "actin filament stabilization" EXACT []
synonym: "down regulation of actin filament depolymerization" EXACT []
synonym: "down-regulation of actin filament depolymerization" EXACT []
synonym: "downregulation of actin filament depolymerization" EXACT []
synonym: "inhibition of actin filament depolymerization" NARROW []
synonym: "negative regulation of actin depolymerization" EXACT []
synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD []
is_a: GO:0030834 ! regulation of actin filament depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1901880 ! negative regulation of protein depolymerization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030836
name: positive regulation of actin filament depolymerization
namespace: biological_process
alt_id: GO:0030045
def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838').
synonym: "actin filament destabilization" EXACT []
synonym: "activation of actin filament depolymerization" NARROW []
synonym: "positive regulation of actin depolymerization" EXACT []
synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD []
synonym: "stimulation of actin filament depolymerization" NARROW []
synonym: "up regulation of actin filament depolymerization" EXACT []
synonym: "up-regulation of actin filament depolymerization" EXACT []
synonym: "upregulation of actin filament depolymerization" EXACT []
is_a: GO:0030834 ! regulation of actin filament depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1901881 ! positive regulation of protein depolymerization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030837
name: negative regulation of actin filament polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835').
synonym: "down regulation of actin filament polymerization" EXACT []
synonym: "down-regulation of actin filament polymerization" EXACT []
synonym: "downregulation of actin filament polymerization" EXACT []
synonym: "inhibition of actin filament polymerization" NARROW []
synonym: "negative regulation of actin polymerization" EXACT []
synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD []
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030838
name: positive regulation of actin filament polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836').
synonym: "activation of actin filament polymerization" NARROW []
synonym: "positive regulation of actin polymerization" EXACT []
synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD []
synonym: "stimulation of actin filament polymerization" NARROW []
synonym: "up regulation of actin filament polymerization" EXACT []
synonym: "up-regulation of actin filament polymerization" EXACT []
synonym: "upregulation of actin filament polymerization" EXACT []
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030839
name: regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah]
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization
relationship: regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030840
name: negative regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843').
synonym: "down regulation of intermediate filament polymerization" EXACT []
synonym: "down-regulation of intermediate filament polymerization" EXACT []
synonym: "downregulation of intermediate filament polymerization" EXACT []
synonym: "inhibition of intermediate filament polymerization" NARROW []
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD []
is_a: GO:0030839 ! regulation of intermediate filament polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030841
name: positive regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844').
synonym: "activation of intermediate filament polymerization" NARROW []
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD []
synonym: "stimulation of intermediate filament polymerization" NARROW []
synonym: "up regulation of intermediate filament polymerization" EXACT []
synonym: "up-regulation of intermediate filament polymerization" EXACT []
synonym: "upregulation of intermediate filament polymerization" EXACT []
is_a: GO:0030839 ! regulation of intermediate filament polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030842
name: regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah]
is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
relationship: regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030843
name: negative regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840').
synonym: "down regulation of intermediate filament depolymerization" EXACT []
synonym: "down-regulation of intermediate filament depolymerization" EXACT []
synonym: "downregulation of intermediate filament depolymerization" EXACT []
synonym: "inhibition of intermediate filament depolymerization" NARROW []
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD []
is_a: GO:0030842 ! regulation of intermediate filament depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1901880 ! negative regulation of protein depolymerization
relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030844
name: positive regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841').
synonym: "activation of intermediate filament depolymerization" NARROW []
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD []
synonym: "stimulation of intermediate filament depolymerization" NARROW []
synonym: "up regulation of intermediate filament depolymerization" EXACT []
synonym: "up-regulation of intermediate filament depolymerization" EXACT []
synonym: "upregulation of intermediate filament depolymerization" EXACT []
is_a: GO:0030842 ! regulation of intermediate filament depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1901881 ! positive regulation of protein depolymerization
relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030845
name: phospholipase C-inhibiting G protein-coupled receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) inhibition.
synonym: "G-protein-coupled inhibitory pathway of phospholipase C" EXACT [PMID:8280098]
synonym: "GPCR signaling pathway coupled to inhibition of phospholipase C activity" EXACT [GOC:signaling]
synonym: "GPCR signaling pathway via inhibition of PLC" EXACT [GOC:signaling]
synonym: "inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway" NARROW [GOC:mah]
synonym: "phospholipase C inhibition" RELATED [GOC:dph, GOC:tb]
synonym: "phospholipase C-inhibiting G-protein coupled receptor signaling pathway" EXACT []
synonym: "PLC-inhibiting GPCR signaling pathway" EXACT [GOC:signaling]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0030846
name: termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "An RNA polymerase II transcription termination process in which cleavage and polyadenylylation of the mRNA 3' end are coupled to transcription termination." [GOC:txnOH, PMID:12944462, PMID:18679429, PMID:27371117]
synonym: "termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED []
synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED []
is_a: GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:0030847
name: termination of RNA polymerase II transcription, exosome-dependent
namespace: biological_process
def: "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [GOC:txnOH, PMID:12944462, PMID:18679429, PMID:27371117]
synonym: "termination of RNA polymerase II transcription, poly(A)-independent" EXACT []
synonym: "transcription termination from Pol II promoter, poly(A)-independent" EXACT []
synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" EXACT []
is_a: GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:0030848
name: threo-3-hydroxyaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate." [EC:4.3.1.16, RHEA:12424]
synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099]
synonym: "L-threo-3-hydroxyaspartate dehydratase activity" RELATED [EC:4.3.1.16]
synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" RELATED [EC:4.3.1.16]
synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" RELATED [EC:4.3.1.16]
synonym: "threo-3-hydroxyaspartate dehydratase activity" RELATED [EC:4.3.1.16]
xref: EC:4.3.1.16
xref: KEGG_REACTION:R05758
xref: MetaCyc:4.3.1.16-RXN
xref: RHEA:12424
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0030849
name: autosome
namespace: cellular_component
def: "Any chromosome other than a sex chromosome." [GOC:mah]
comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism.
xref: Wikipedia:Autosome
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0030850
name: prostate gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751]
synonym: "prostate development" EXACT []
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048732 ! gland development
relationship: part_of GO:0001655 ! urogenital system development

[Term]
id: GO:0030851
name: granulocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm]
synonym: "granulocyte cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030852
name: regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030853
name: negative regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "down regulation of granulocyte differentiation" EXACT []
synonym: "down-regulation of granulocyte differentiation" EXACT []
synonym: "downregulation of granulocyte differentiation" EXACT []
synonym: "inhibition of granulocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: negatively_regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030854
name: positive regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "activation of granulocyte differentiation" NARROW []
synonym: "stimulation of granulocyte differentiation" NARROW []
synonym: "up regulation of granulocyte differentiation" EXACT []
synonym: "up-regulation of granulocyte differentiation" EXACT []
synonym: "upregulation of granulocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: positively_regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030855
name: epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060429 ! epithelium development

[Term]
id: GO:0030856
name: regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030857
name: negative regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of epithelial cell differentiation" EXACT []
synonym: "down-regulation of epithelial cell differentiation" EXACT []
synonym: "downregulation of epithelial cell differentiation" EXACT []
synonym: "inhibition of epithelial cell differentiation" NARROW []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030858
name: positive regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "activation of epithelial cell differentiation" NARROW []
synonym: "stimulation of epithelial cell differentiation" NARROW []
synonym: "up regulation of epithelial cell differentiation" EXACT []
synonym: "up-regulation of epithelial cell differentiation" EXACT []
synonym: "upregulation of epithelial cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030859
name: polarized epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium

[Term]
id: GO:0030860
name: regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030861
name: negative regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of polarized epithelial cell differentiation" EXACT []
synonym: "down-regulation of polarized epithelial cell differentiation" EXACT []
synonym: "downregulation of polarized epithelial cell differentiation" EXACT []
synonym: "inhibition of polarized epithelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation
relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030862
name: positive regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah]
synonym: "activation of polarized epithelial cell differentiation" NARROW []
synonym: "stimulation of polarized epithelial cell differentiation" NARROW []
synonym: "up regulation of polarized epithelial cell differentiation" EXACT []
synonym: "up-regulation of polarized epithelial cell differentiation" EXACT []
synonym: "upregulation of polarized epithelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation
relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030863
name: cortical cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0030864
name: cortical actin cytoskeleton
namespace: cellular_component
def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0030865
name: cortical cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
synonym: "cortical cytoskeleton organisation" EXACT []
synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0030866
name: cortical actin cytoskeleton organization
namespace: biological_process
alt_id: GO:0033109
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:pf]
synonym: "actin cortex stabilization" EXACT []
synonym: "cortical actin cytoskeleton organisation" EXACT []
synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "cortical actin cytoskeleton stabilization" EXACT []
synonym: "cortical resistance" RELATED []
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0030865 ! cortical cytoskeleton organization

[Term]
id: GO:0030867
name: rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah]
synonym: "RER membrane" EXACT [NIF_Subcellular:sao3089754107]
synonym: "rough ER membrane" EXACT []
xref: NIF_Subcellular:sao3089754107
is_a: GO:0005789 ! endoplasmic reticulum membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0030868
name: smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah]
synonym: "SER membrane" EXACT []
synonym: "smooth ER membrane" EXACT []
xref: NIF_Subcellular:sao1596955044
is_a: GO:0005789 ! endoplasmic reticulum membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0030869
name: RENT complex
namespace: cellular_component
def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389]
is_a: GO:0005677 ! chromatin silencing complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0030870
name: Mre11 complex
namespace: cellular_component
def: "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]
synonym: "MRN complex" EXACT []
synonym: "MRX complex" EXACT []
synonym: "Rad50 complex" EXACT []
synonym: "RAD50-MRE11-NBN complex" EXACT [CORUM:2767]
synonym: "Rad50-Rad32-Nbs1 complex" EXACT []
synonym: "RMX complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0030874
name: nucleolar chromatin
namespace: cellular_component
def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah]
is_a: GO:0000785 ! chromatin
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0030875
name: rDNA protrusion
namespace: cellular_component
def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244]
comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern.
synonym: "ribosomal DNA protrusion" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030874 ! nucleolar chromatin

[Term]
id: GO:0030876
name: interleukin-20 receptor complex
namespace: cellular_component
def: "A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits." [PMID:12351624]
synonym: "IL-20 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0030877
name: beta-catenin destruction complex
namespace: cellular_component
alt_id: GO:0034742
alt_id: GO:0034747
def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "23S APC complex" NARROW []
synonym: "APC-Axin-1-beta-catenin complex" EXACT []
synonym: "Axin-APC-beta-catenin-GSK3B complex" EXACT []
synonym: "BDC" EXACT [GOC:bf, GOC:PARL, PMID:22899650]
synonym: "beta-catenin degradation complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0030878
name: thyroid gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0030879
name: mammary gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833]
synonym: "mammogenesis" NARROW [GOC:dph]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0030880
name: RNA polymerase complex
namespace: cellular_component
def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]
subset: goslim_pir
synonym: "multisubunit RNA polymerase" EXACT []
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0030881
name: beta-2-microglobulin binding
namespace: molecular_function
def: "Binding to beta-2-microglobulin." [GOC:mah]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030882
name: lipid antigen binding
namespace: molecular_function
def: "Binding to a lipid antigen." [PMID:14500461]
is_a: GO:0003823 ! antigen binding
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0030883
name: endogenous lipid antigen binding
namespace: molecular_function
def: "Binding to an endogenous cellular lipid antigen." [PMID:14500461]
is_a: GO:0030882 ! lipid antigen binding

[Term]
id: GO:0030884
name: exogenous lipid antigen binding
namespace: molecular_function
def: "Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461]
is_a: GO:0030882 ! lipid antigen binding

[Term]
id: GO:0030885
name: regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030886
name: negative regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah]
synonym: "down regulation of myeloid dendritic cell activation" EXACT []
synonym: "down-regulation of myeloid dendritic cell activation" EXACT []
synonym: "downregulation of myeloid dendritic cell activation" EXACT []
synonym: "inhibition of myeloid dendritic cell activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030887
name: positive regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah]
synonym: "activation of myeloid dendritic cell activation" NARROW []
synonym: "stimulation of myeloid dendritic cell activation" NARROW []
synonym: "up regulation of myeloid dendritic cell activation" EXACT []
synonym: "up-regulation of myeloid dendritic cell activation" EXACT []
synonym: "upregulation of myeloid dendritic cell activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030888
name: regulation of B cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah]
synonym: "regulation of B lymphocyte proliferation" EXACT []
synonym: "regulation of B-cell proliferation" EXACT []
synonym: "regulation of B-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050864 ! regulation of B cell activation
relationship: regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030889
name: negative regulation of B cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah]
synonym: "down regulation of B cell proliferation" EXACT []
synonym: "down-regulation of B cell proliferation" EXACT []
synonym: "downregulation of B cell proliferation" EXACT []
synonym: "inhibition of B cell proliferation" NARROW []
synonym: "negative regulation of B lymphocyte proliferation" EXACT []
synonym: "negative regulation of B-cell proliferation" EXACT []
synonym: "negative regulation of B-lymphocyte proliferation" EXACT []
is_a: GO:0030888 ! regulation of B cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050869 ! negative regulation of B cell activation
relationship: negatively_regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030890
name: positive regulation of B cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah]
synonym: "activation of B cell proliferation" NARROW []
synonym: "positive regulation of B lymphocyte proliferation" EXACT []
synonym: "positive regulation of B-cell proliferation" EXACT []
synonym: "positive regulation of B-lymphocyte proliferation" EXACT []
synonym: "stimulation of B cell proliferation" NARROW []
synonym: "up regulation of B cell proliferation" EXACT []
synonym: "up-regulation of B cell proliferation" EXACT []
synonym: "upregulation of B cell proliferation" EXACT []
is_a: GO:0030888 ! regulation of B cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050871 ! positive regulation of B cell activation
relationship: positively_regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030891
name: VCB complex
namespace: cellular_component
def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071]
synonym: "pVHL-elongin C-elongin B complex" EXACT []
synonym: "VHL complex" EXACT []
synonym: "von Hippel-Lindau tumor suppressor complex" EXACT []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex

[Term]
id: GO:0030892
name: mitotic cohesin complex
namespace: cellular_component
alt_id: GO:0034990
def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522]
synonym: "nuclear mitotic cohesin complex" RELATED []
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030893
name: meiotic cohesin complex
namespace: cellular_component
alt_id: GO:0034991
def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522]
synonym: "nuclear meiotic cohesin complex" RELATED []
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030894
name: replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]
subset: goslim_pir
synonym: "DNA synthesome complex" RELATED [CORUM:1001]
synonym: "RC complex" RELATED [CORUM:309, PMID:12006500]
synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500]
xref: Wikipedia:Replisome
is_a: GO:0032993 ! protein-DNA complex
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0030895
name: apolipoprotein B mRNA editing enzyme complex
namespace: cellular_component
def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591, PMID:12683974]
comment: ASP = APOBEC1 complementation factor 1, a1cf, acf; KSRP = Khsrp (KH-type splicing regulatory protein)
synonym: "apoB mRNA editing enzyme complex" EXACT []
synonym: "APOBEC" EXACT []
is_a: GO:0045293 ! mRNA editing complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0030896
name: checkpoint clamp complex
namespace: cellular_component
def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]
comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p.
synonym: "CCC" EXACT []
synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0030897
name: HOPS complex
namespace: cellular_component
def: "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0099023 ! vesicle tethering complex

[Term]
id: GO:0030899
name: calcium-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)." [GOC:mah]
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0030900
name: forebrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [PMID:4975589, PMID:4992177]
synonym: "prosencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030901
name: midbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177]
synonym: "mesencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030902
name: hindbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [PMID:4975589, PMID:4992177]
synonym: "rhombencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030903
name: notochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh]
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0030904
name: retromer complex
namespace: cellular_component
def: "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157]
subset: goslim_pir
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030905
name: retromer, tubulation complex
namespace: cellular_component
def: "The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodeling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6." [GOC:bf, PMID:26220253, PMID:9700157]
synonym: "heterodimeric membrane-deforming retromer subcomplex" EXACT [GOC:bf, GOC:PARL, PMID:22193161]
synonym: "retromer complex, outer shell" EXACT []
synonym: "SNX-BAR dimer" EXACT [PMID:26220253]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030906
name: retromer, cargo-selective complex
namespace: cellular_component
def: "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157]
synonym: "cargo-selective retromer subcomplex" EXACT [PMID:19531583, PMID:20923837]
synonym: "retromer complex, inner shell" EXACT []
synonym: "retromer CSC" EXACT [GOC:bf, GOC:PARL]
synonym: "retromer, cargo recognition complex" EXACT [PMID:26220253]
synonym: "retromer, CRC" EXACT [GOC:bf, GOC:PARL, PMID:26220253]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030907
name: MBF transcription complex
namespace: cellular_component
def: "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385]
synonym: "DSC1 transcription factor complex" EXACT []
synonym: "MBF" EXACT []
synonym: "Mlu1-box binding factor" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0030908
name: protein splicing
namespace: biological_process
def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah]
xref: Wikipedia:Protein_splicing
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0030909
name: non-intein-mediated protein splicing
namespace: biological_process
def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah]
is_a: GO:0030908 ! protein splicing

[Term]
id: GO:0030910
name: olfactory placode formation
namespace: biological_process
def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0043584 ! nose development
relationship: part_of GO:0071699 ! olfactory placode morphogenesis

[Term]
id: GO:0030911
name: TPR domain binding
namespace: molecular_function
def: "Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]
synonym: "tetratricopeptide repeat domain binding" EXACT [GOC:sl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030912
name: response to deep water
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah]
comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale.
is_a: GO:0009415 ! response to water

[Term]
id: GO:0030913
name: paranodal junction assembly
namespace: biological_process
def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942]
synonym: "paranodal axoglial junction formation" EXACT [PMID:18803321]
synonym: "paranodal junction biosynthesis" EXACT []
synonym: "paranodal junction formation" EXACT []
is_a: GO:0007043 ! cell-cell junction assembly
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0032288 ! myelin assembly

[Term]
id: GO:0030915
name: Smc5-Smc6 complex
namespace: cellular_component
def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]
is_a: GO:0106068 ! SUMO ligase complex
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0030916
name: otic vesicle formation
namespace: biological_process
def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh]
synonym: "otocyst biosynthesis" EXACT []
synonym: "otocyst formation" EXACT []
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0071600 ! otic vesicle morphogenesis

[Term]
id: GO:0030917
name: midbrain-hindbrain boundary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh]
synonym: "isthmic organizer development" EXACT []
synonym: "isthmomesencephalic boundary development" EXACT []
synonym: "isthmus development" EXACT []
synonym: "MHB development" EXACT []
synonym: "midbrain-hindbrain orgainizer development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0030919
name: peptidyl-serine O-acetylation
namespace: biological_process
def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0364
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030920 ! peptidyl-serine acetylation

[Term]
id: GO:0030920
name: peptidyl-serine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-serine." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006473 ! protein acetylation

[Term]
id: GO:0030921
name: obsolete peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine
namespace: biological_process
def: "OBSOLETE. The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0030922
name: obsolete peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine
namespace: biological_process
def: "OBSOLETE. The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0030923
name: obsolete metal incorporation into metallo-oxygen cluster
namespace: biological_process
def: "OBSOLETE. The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg]
comment: This term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0030924
name: obsolete manganese incorporation into metallo-oxygen cluster
namespace: biological_process
def: "OBSOLETE. The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg]
comment: This term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0030925
name: obsolete calcium incorporation into metallo-oxygen cluster
namespace: biological_process
def: "OBSOLETE. The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg]
comment: This term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0030926
name: obsolete calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
namespace: biological_process
def: "OBSOLETE. The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]
comment: This term represents a molecular function.
xref: RESID:AA0366
is_obsolete: true

[Term]
id: GO:0030927
name: obsolete manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
namespace: biological_process
def: "OBSOLETE. The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]
comment: This term represents a molecular function.
xref: RESID:AA0366
is_obsolete: true

[Term]
id: GO:0030929
name: ADPG pyrophosphorylase complex
namespace: cellular_component
def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965]
subset: goslim_pir
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0030930
name: homotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030931
name: heterotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030932
name: amyloplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0030933
name: chloroplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0030934
name: anchoring collagen complex
namespace: cellular_component
def: "Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976]
synonym: "connecting collagen" EXACT [ISBN:0721639976]
synonym: "linking collagen" EXACT [ISBN:0721639976]
is_a: GO:0005581 ! collagen trimer
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0030935
name: sheet-forming collagen trimer
namespace: cellular_component
def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet." [PMID:7188361]
synonym: "hexagonal network-forming collagen" EXACT [ISBN:0815316194]
is_a: GO:0098642 ! network-forming collagen trimer
relationship: part_of GO:0098646 ! collagen sheet

[Term]
id: GO:0030936
name: transmembrane collagen trimer
namespace: cellular_component
def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976]
synonym: "MACIT" EXACT [ISBN:0198599587]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0030937
name: collagen type XVII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin." [ISBN:0721639976, PMID:19693541, PMID:21421911]
is_a: GO:0030936 ! transmembrane collagen trimer
is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion
is_a: GO:0098733 ! hemidesmosome associated protein complex

[Term]
id: GO:0030938
name: collagen type XVIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976, PMID:21421911]
is_a: GO:0098651 ! basement membrane collagen trimer

[Term]
id: GO:0030939
name: obsolete response to long-day photoperiod
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj]
comment: This term was made obsolete because it was wrongly defined.
synonym: "response to long-day photoperiod" EXACT []
is_obsolete: true
consider: GO:0048571

[Term]
id: GO:0030940
name: obsolete response to short-day photoperiod
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj]
comment: This term was made obsolete because it was wrongly defined.
synonym: "response to short-day photoperiod" EXACT []
is_obsolete: true
consider: GO:0048572

[Term]
id: GO:0030941
name: chloroplast targeting sequence binding
namespace: molecular_function
def: "Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah]
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030942
name: endoplasmic reticulum signal peptide binding
namespace: molecular_function
def: "Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah]
synonym: "ER signal peptide binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030943
name: mitochondrion targeting sequence binding
namespace: molecular_function
def: "Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah]
synonym: "mitochondrial targeting sequence binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030944
name: DDEL sequence binding
namespace: molecular_function
def: "Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah]
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0030945
name: obsolete protein tyrosine phosphatase activity, via thiol-phosphate intermediate
namespace: molecular_function
def: "OBSOLETE. The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd]
comment: This term was obsoleted because it represents a specific substrate of protein tyrosine phosphatase activity ; GO:0004725.
is_obsolete: true
replaced_by: GO:0004725

[Term]
id: GO:0030946
name: protein tyrosine phosphatase activity, metal-dependent
namespace: molecular_function
def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions." [GOC:mah]
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0030947
name: regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "regulation of VEGF receptor signaling pathway" EXACT []
synonym: "regulation of VEGF receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030948
name: negative regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "negative regulation of VEGF receptor signaling pathway" EXACT []
synonym: "negative regulation of VEGF receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030949
name: positive regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "positive regulation of VEGF receptor signaling pathway" EXACT []
synonym: "positive regulation of VEGF receptor signalling pathway" EXACT []
synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway
relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030950
name: establishment or maintenance of actin cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030951
name: establishment or maintenance of microtubule cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030952
name: establishment or maintenance of cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah]
synonym: "cytoskeleton polarization" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030953
name: astral microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah]
synonym: "astral microtubule organisation" EXACT []
synonym: "astral microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007051 ! spindle organization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0030954
name: astral microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah]
is_a: GO:0030953 ! astral microtubule organization
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center

[Term]
id: GO:0030955
name: potassium ion binding
namespace: molecular_function
def: "Binding to a potassium ion (K+)." [GOC:mah]
synonym: "K ion binding" EXACT []
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0030956
name: glutamyl-tRNA(Gln) amidotransferase complex
namespace: cellular_component
def: "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'.
synonym: "AdT" RELATED [GOC:rb]
synonym: "GatCAB" NARROW [GOC:rb]
synonym: "GatFAB" NARROW [GOC:rb]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0030957
name: Tat protein binding
namespace: molecular_function
def: "Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689]
is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding

[Term]
id: GO:0030958
name: RITS complex
namespace: cellular_component
def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433]
is_a: GO:0031332 ! RNAi effector complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000792 ! heterochromatin

[Term]
id: GO:0030959
name: obsolete peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0367
is_obsolete: true

[Term]
id: GO:0030960
name: obsolete peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def: "OBSOLETE. The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0368
is_obsolete: true

[Term]
id: GO:0030961
name: peptidyl-arginine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0030962
name: obsolete peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine
namespace: biological_process
def: "OBSOLETE. The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0030963
name: obsolete peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine
namespace: biological_process
def: "OBSOLETE. The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0030964
name: NADH dehydrogenase complex
namespace: cellular_component
alt_id: GO:0030025
alt_id: GO:0030966
alt_id: GO:0031675
alt_id: GO:0031677
alt_id: GO:0031678
alt_id: GO:0045280
def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'.
subset: goslim_pir
synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW []
synonym: "NADH dehydrogenase complex (quinone)" NARROW []
synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW []
synonym: "NADH:plastoquinone reductase complex" NARROW []
synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW []
xref: Wikipedia:NADH_dehydrogenase
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0030965
name: plasma membrane electron transport, NADH to quinone
namespace: biological_process
def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd]
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport

[Term]
id: GO:0030968
name: endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]
comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.
synonym: "ER unfolded protein response" EXACT []
synonym: "erUPR" EXACT []
synonym: "SREBP-mediated signalling pathway" RELATED []
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0035556 ! intracellular signal transduction
relationship: part_of GO:0034620 ! cellular response to unfolded protein

[Term]
id: GO:0030969
name: obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response
namespace: biological_process
def: "OBSOLETE. The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763, PMID:21924241]
comment: The reason for obsoletion is that this process represent a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498).
synonym: "HAC1 mRNA splicing" NARROW [PMID:21924241]
synonym: "IRE1-mediated XBP-1 mRNA splicing" NARROW [GOC:bf]
synonym: "Ire1p-mediated HAC-1 mRNA splicing" NARROW [GOC:bf]
synonym: "non-spliceosomal mRNA splicing in the unfolded protein response pathway" EXACT [PMID:10357823]
synonym: "spliceosome-independent UFP-specific transcription factor mRNA processing" EXACT [GOC:dph]
synonym: "UFP-specific transcription factor mRNA processing during unfolded protein response" RELATED [GOC:dph, GOC:tb]
synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response" EXACT [GOC:bf]
synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum UPR" EXACT [GOC:bf]
synonym: "UFP-specific transcription factor mRNA processing involved in ER unfolded protein response" EXACT [GOC:bf]
synonym: "UFP-specific transcription factor mRNA processing involved in ER UPR" EXACT [GOC:bf]
synonym: "unconventional mRNA splicing involved in UPR" EXACT [GOC:bf]
synonym: "unconventional splicing of XBP1 mRNA" EXACT [PMID:11779464, PMID:26068456]
synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED []
synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED []
synonym: "XBP1 mRNA splicing" EXACT [PMID:11779464, PMID:25968568]
synonym: "XBP1 mRNA splicing under conditions of endoplasmic reticulum (ER) stress" NARROW [PMID:21924241]
synonym: "XBP1 mRNA splicing, via endonucleolytic cleavage and ligation" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0036498

[Term]
id: GO:0030970
name: retrograde protein transport, ER to cytosol
namespace: biological_process
def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744]
synonym: "protein dislocation from ER" EXACT [GOC:dph, GOC:krc]
synonym: "protein retrotranslocation, ER to cytosol" EXACT [GOC:bf]
synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT []
is_a: GO:0032527 ! protein exit from endoplasmic reticulum
is_a: GO:1903513 ! endoplasmic reticulum to cytosol transport
relationship: part_of GO:0036503 ! ERAD pathway

[Term]
id: GO:0030971
name: receptor tyrosine kinase binding
namespace: molecular_function
def: "Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]
synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED []
is_a: GO:0005102 ! signaling receptor binding
is_a: GO:1990782 ! protein tyrosine kinase binding

[Term]
id: GO:0030972
name: obsolete cleavage of cytosolic proteins involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. The proteolytic degradation of proteins in the cytosol that contributes to apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181]
comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.
synonym: "apoptotic cleavage of cytosolic proteins" EXACT []
synonym: "cleavage of cytosolic proteins involved in apoptosis" BROAD []
synonym: "cleavage of cytosolic proteins involved in execution phase of apoptosis" EXACT []
is_obsolete: true
consider: GO:0004197

[Term]
id: GO:0030973
name: molybdate ion binding
namespace: molecular_function
def: "Binding to a molybdate ion (MoO4 2-)." [GOC:mlg]
synonym: "MoO4 ion binding" EXACT []
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0030974
name: thiamine pyrophosphate transmembrane transport
namespace: biological_process
def: "The process in which thiamine pyrophosphate is transported across a membrane." [GOC:mlg]
synonym: "thiamin diphosphate transport" EXACT []
synonym: "thiamin pyrophosphate transport" EXACT []
synonym: "thiamine diphosphate transport" EXACT []
synonym: "thiamine pyrophosphate transport" NARROW []
synonym: "TPP transport" EXACT []
is_a: GO:0015697 ! quaternary ammonium group transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0071934 ! thiamine transmembrane transport

[Term]
id: GO:0030975
name: thiamine binding
namespace: molecular_function
def: "Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg]
synonym: "thiamin binding" EXACT []
synonym: "vitamin B1 binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0043169 ! cation binding
is_a: GO:0043178 ! alcohol binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0030976
name: thiamine pyrophosphate binding
namespace: molecular_function
def: "Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]
synonym: "aneurine pyrophosphate binding" EXACT []
synonym: "cocarboxylase binding" EXACT []
synonym: "diphosphothiamin binding" EXACT []
synonym: "thiamin pyrophosphate binding" EXACT []
synonym: "TPP binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043169 ! cation binding
is_a: GO:0050997 ! quaternary ammonium group binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0030977
name: taurine binding
namespace: molecular_function
def: "Binding to taurine." [GOC:mlg]
is_a: GO:0043210 ! alkanesulfonate binding

[Term]
id: GO:0030978
name: alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]
synonym: "alpha-glucan metabolism" EXACT []
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0030979
name: alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]
synonym: "alpha-glucan anabolism" EXACT []
synonym: "alpha-glucan biosynthesis" EXACT []
synonym: "alpha-glucan formation" EXACT []
synonym: "alpha-glucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0030980
name: alpha-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah]
synonym: "alpha-glucan breakdown" EXACT []
synonym: "alpha-glucan catabolism" EXACT []
synonym: "alpha-glucan degradation" EXACT []
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0030981
name: cortical microtubule cytoskeleton
namespace: cellular_component
def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0030982
name: adventurous gliding motility
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173]
synonym: "adventurous gliding movement" EXACT []
is_a: GO:0071976 ! cell gliding

[Term]
id: GO:0030983
name: mismatched DNA binding
namespace: molecular_function
alt_id: GO:0032134
def: "Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]
synonym: "mispair binding" EXACT []
synonym: "mispaired DNA binding" EXACT []
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0030984
name: kininogen binding
namespace: molecular_function
def: "Binding to a kininogen, a kinin precursor." [GOC:mah, PMID:9520414]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030985
name: high molecular weight kininogen binding
namespace: molecular_function
def: "Binding to a kininogen of high molecular mass." [GOC:mah, PMID:9520414]
synonym: "HK binding" EXACT []
synonym: "HMW kininogen binding" EXACT []
is_a: GO:0030984 ! kininogen binding

[Term]
id: GO:0030986
name: low molecular weight kininogen binding
namespace: molecular_function
def: "Binding to a kininogen of low molecular mass." [GOC:mah, PMID:9520414]
synonym: "LK binding" EXACT []
synonym: "LMW kininogen binding" EXACT []
is_a: GO:0030984 ! kininogen binding

[Term]
id: GO:0030987
name: high molecular weight kininogen receptor binding
namespace: molecular_function
def: "Binding to a high molecular weight kininogen receptor." [GOC:mah]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0030988
name: high molecular weight kininogen receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0030989
name: dynein-driven meiotic oscillatory nuclear movement
namespace: biological_process
def: "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein." [GOC:vw, PMID:16111942, PMID:9572142]
comment: Dynein-driven meiotic oscillatory nuclear movement precedes meiotic recombination.
synonym: "HNM" EXACT []
synonym: "horsetail movement" EXACT []
synonym: "horsetail nuclear movement" EXACT [GOC:vw]
is_a: GO:0030473 ! nuclear migration along microtubule
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0030990
name: intraciliary transport particle
namespace: cellular_component
def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
subset: goslim_pir
synonym: "IFT complex" RELATED []
synonym: "intraflagellar transport complex" EXACT []
synonym: "intraflagellar transport particle" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0030991
name: intraciliary transport particle A
namespace: cellular_component
def: "The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
synonym: "IFT A complex" RELATED []
synonym: "IFT complex A" RELATED []
synonym: "intraflagellar transport complex A" EXACT []
synonym: "intraflagellar transport particle A" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030990 ! intraciliary transport particle

[Term]
id: GO:0030992
name: intraciliary transport particle B
namespace: cellular_component
def: "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
synonym: "IFT B complex" RELATED []
synonym: "IFT complex B" RELATED []
synonym: "intraflagellar transport complex B" EXACT []
synonym: "intraflagellar transport particle B" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030990 ! intraciliary transport particle

[Term]
id: GO:0030993
name: axonemal heterotrimeric kinesin-II complex
namespace: cellular_component
def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0030994
name: primary cell septum disassembly
namespace: biological_process
def: "Dissolution of the primary septum during cell separation." [PMID:12665550]
synonym: "hydrolysis of primary cell septum" EXACT []
synonym: "primary cell septum hydrolysis" EXACT []
synonym: "primary septum hydrolysis" BROAD []
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0000920 ! septum digestion after cytokinesis

[Term]
id: GO:0030995
name: cell septum edging catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814]
synonym: "cell septum edging hydrolysis" EXACT []
synonym: "hydrolysis of cell septum edging" EXACT []
synonym: "hydrolysis of edging of cell septum" EXACT []
synonym: "septum edging hydrolysis" BROAD []
is_a: GO:0000272 ! polysaccharide catabolic process
relationship: part_of GO:0000920 ! septum digestion after cytokinesis

[Term]
id: GO:0030996
name: obsolete mitotic cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:mah, GOC:tb, GOC:vw]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
synonym: "cell cycle arrest in response to nitrogen starvation" BROAD []
is_obsolete: true

[Term]
id: GO:0030997
name: regulation of centriole-centriole cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: part_of GO:0007098 ! centrosome cycle
relationship: regulates GO:0010457 ! centriole-centriole cohesion

[Term]
id: GO:0030998
name: linear element
namespace: cellular_component
def: "A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex." [DOI:10.2323/jgam.28.263, GOC:jb, PMID:12665553, PMID:30640914]
is_a: GO:0099086 ! synaptonemal structure

[Term]
id: GO:0030999
name: linear element assembly
namespace: biological_process
def: "The cell cycle process in which linear elements are assembled in association with fission yeast chromosomes during meiotic prophase. Linear element assembly begins with LinE complex formation and ends when LinE complexes are associated with chromatin in structures visible as nuclear foci. A linear element is a proteinaceous scaffold related to the synaptonemal complex." [GOC:jb, GOC:mah, PMID:30640914]
synonym: "linear element formation" RELATED [GOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis

[Term]
id: GO:0031000
name: response to caffeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:ef, GOC:mah]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0031001
name: response to brefeldin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0031002
name: actin rod
namespace: cellular_component
def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions." [GOC:kp, GOC:krc, PMID:11858703, PMID:19459188, PMID:22623727, PMID:24813767, PMID:27535426, PMID:7820870]
is_a: GO:0032432 ! actin filament bundle

[Term]
id: GO:0031003
name: actin tubule
namespace: cellular_component
def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp]
is_a: GO:0032432 ! actin filament bundle
relationship: part_of GO:0031002 ! actin rod

[Term]
id: GO:0031004
name: potassium ion-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692]
synonym: "Kdp system complex" EXACT []
is_a: GO:0090533 ! cation-transporting ATPase complex

[Term]
id: GO:0031005
name: filamin binding
namespace: molecular_function
alt_id: GO:0031006
alt_id: GO:0031007
alt_id: GO:0031008
def: "Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782]
synonym: "ABP-278/276 binding" NARROW []
synonym: "ABP-280 binding" NARROW []
synonym: "ABPL binding" NARROW []
synonym: "alpha-filamin binding" NARROW []
synonym: "beta-filamin binding" NARROW []
synonym: "filamin A binding" NARROW []
synonym: "filamin B binding" NARROW []
synonym: "filamin C binding" EXACT []
synonym: "filamin-1 binding" NARROW []
synonym: "filamin-2 binding" NARROW []
synonym: "filamin-3 binding" NARROW []
synonym: "filamin-A binding" NARROW []
synonym: "filamin-B binding" EXACT []
synonym: "filamin-C binding" NARROW []
synonym: "gamma-filamin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031009
name: plastid ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah]
is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0031010
name: ISWI-type complex
namespace: cellular_component
def: "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0031011
name: Ino80 complex
namespace: cellular_component
def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]
synonym: "INO80 chromatin remodeling complex" EXACT []
is_a: GO:0097346 ! INO80-type complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0031012
name: extracellular matrix
namespace: cellular_component
alt_id: GO:0005578
def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
synonym: "matrisome" NARROW []
synonym: "proteinaceous extracellular matrix" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090513
xref: Wikipedia:Extracellular_matrix
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0031013
name: troponin I binding
namespace: molecular_function
def: "Binding to troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031014
name: troponin T binding
namespace: molecular_function
def: "Binding to troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031015
name: obsolete karyopherin docking complex
namespace: cellular_component
def: "OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357]
synonym: "Asm4p-containing complex" NARROW []
synonym: "karyopherin docking complex" EXACT []
synonym: "nuclear pore subcomplex" BROAD []
is_obsolete: true
consider: GO:0017056
consider: GO:0044613

[Term]
id: GO:0031016
name: pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones." [GOC:cvs]
xref: Wikipedia:Pancreas
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0031017
name: exocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035272 ! exocrine system development
relationship: part_of GO:0055123 ! digestive system development

[Term]
id: GO:0031018
name: endocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0031019
name: mitochondrial mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607]
synonym: "mitochondrial editosome" EXACT []
is_a: GO:0045293 ! mRNA editing complex
is_a: GO:0098798 ! mitochondrial protein-containing complex

[Term]
id: GO:0031020
name: plastid mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in a plastid." [GOC:mah]
synonym: "plastid editosome" EXACT []
is_a: GO:0045293 ! mRNA editing complex
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0031021
name: interphase microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790]
synonym: "iMTOC" EXACT []
synonym: "interphase microtubule organising center" EXACT []
synonym: "interphase MTOC" EXACT []
is_a: GO:0005815 ! microtubule organizing center

[Term]
id: GO:0031022
name: nuclear migration along microfilament
namespace: biological_process
def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah]
synonym: "nuclear migration, microfilament-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport

[Term]
id: GO:0031023
name: microtubule organizing center organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "microtubule organising center organisation" EXACT []
synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031024
name: interphase microtubule organizing center assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790]
synonym: "interphase microtubule organising center biosynthesis" EXACT []
synonym: "interphase microtubule organising center formation" EXACT []
synonym: "interphase microtubule organizing center biogenesis" RELATED [GOC:mah]
synonym: "interphase microtubule organizing centre assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0031025
name: equatorial microtubule organizing center disassembly
namespace: biological_process
def: "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790]
synonym: "equatorial microtubule organising center disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0031023 ! microtubule organizing center organization
is_a: GO:0031121 ! equatorial microtubule organization

[Term]
id: GO:0031026
name: glutamate synthase complex
namespace: cellular_component
def: "A complex that possesses glutamate synthase activity." [GOC:mah]
subset: goslim_pir
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0031027
name: glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0031028
name: septation initiation signaling
namespace: biological_process
def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007]
synonym: "septation initiation network" EXACT []
synonym: "septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "septation initiation signalling" EXACT []
synonym: "SIN" EXACT []
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0031029
name: regulation of septation initiation signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "regulation of septation initiation network" EXACT []
synonym: "regulation of septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of septation initiation signalling" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031030
name: negative regulation of septation initiation signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "down regulation of septation initiation signaling" EXACT []
synonym: "down-regulation of septation initiation signaling" EXACT []
synonym: "downregulation of septation initiation signaling" EXACT []
synonym: "inhibition of septation initiation signaling" NARROW []
synonym: "negative regulation of septation initiation network" EXACT []
synonym: "negative regulation of septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of septation initiation signalling" EXACT []
is_a: GO:0010974 ! negative regulation of division septum assembly
is_a: GO:0031029 ! regulation of septation initiation signaling
is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction
relationship: negatively_regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031031
name: positive regulation of septation initiation signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "activation of septation initiation signaling" NARROW []
synonym: "positive regulation of septation initiation network" EXACT []
synonym: "positive regulation of septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of septation initiation signalling" EXACT []
synonym: "stimulation of septation initiation signaling" NARROW []
synonym: "up regulation of septation initiation signaling" EXACT []
synonym: "up-regulation of septation initiation signaling" EXACT []
synonym: "upregulation of septation initiation signaling" EXACT []
is_a: GO:0010973 ! positive regulation of division septum assembly
is_a: GO:0031029 ! regulation of septation initiation signaling
is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction
relationship: positively_regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031032
name: actomyosin structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins.
synonym: "actomyosin organization" EXACT []
synonym: "actomyosin structure organisation" EXACT []
synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0031033
name: myosin filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton.
synonym: "myosin filament assembly or disassembly" RELATED [GOC:mah]
synonym: "myosin filament organisation" EXACT [GOC:mah]
synonym: "myosin polymerization or depolymerization" RELATED []
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0031034
name: myosin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah]
synonym: "myosin polymerization" RELATED []
is_a: GO:0031033 ! myosin filament organization
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0031035
name: myosin filament disassembly
namespace: biological_process
def: "The disassembly of a filament composed of myosin molecules." [GOC:mah]
synonym: "myosin depolymerization" RELATED []
is_a: GO:0031033 ! myosin filament organization
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0031036
name: myosin II filament assembly
namespace: biological_process
def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II polymerization" RELATED []
is_a: GO:0031034 ! myosin filament assembly
is_a: GO:0031038 ! myosin II filament organization

[Term]
id: GO:0031037
name: myosin II filament disassembly
namespace: biological_process
def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II depolymerization" RELATED []
is_a: GO:0031035 ! myosin filament disassembly
is_a: GO:0031038 ! myosin II filament organization

[Term]
id: GO:0031038
name: myosin II filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II filament assembly or disassembly" RELATED [GOC:mah]
synonym: "myosin II filament organisation" EXACT [GOC:mah]
synonym: "myosin II polymerization or depolymerization" RELATED []
is_a: GO:0031033 ! myosin filament organization

[Term]
id: GO:0031039
name: macronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns]
xref: Wikipedia:Macronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031040
name: micronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns]
xref: Wikipedia:Micronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031041
name: obsolete O-glycan processing, core 5
namespace: biological_process
def: "OBSOLETE. The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031042
name: obsolete O-glycan processing, core 6
namespace: biological_process
def: "OBSOLETE. The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031043
name: obsolete O-glycan processing, core 7
namespace: biological_process
def: "OBSOLETE. The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031044
name: obsolete O-glycan processing, core 8
namespace: biological_process
def: "OBSOLETE. The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031045
name: dense core granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495]
synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv]
xref: NIF_Subcellular:sao772007592
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031047
name: regulatory ncRNA-mediated gene silencing
namespace: biological_process
def: "A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation." [PMID:15020054]
subset: goslim_drosophila
subset: goslim_generic
synonym: "gene silencing by RNA" RELATED []
synonym: "RNA-dependent gene silencing" EXACT []
synonym: "RNA-mediated gene silencing" RELATED []
is_a: GO:0010629 ! negative regulation of gene expression

[Term]
id: GO:0031048
name: regulatory ncRNA-mediated heterochromatin formation
namespace: biological_process
alt_id: GO:0070924
alt_id: GO:0140458
def: "A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginning of trancription." [PMID:19239886, PMID:21420348]
synonym: "chromatin silencing by small RNA" RELATED []
synonym: "heterochromatin assembly by small RNA" NARROW []
synonym: "heterochromatin assembly involved in chromatin silencing by small RNA" RELATED []
synonym: "heterochromatin formation involved in chromatin silencing by small RNA" RELATED []
synonym: "ncRNA-mediated heterochromatin formation" EXACT []
synonym: "pre-transcriptional gene silencing by RNA" BROAD []
synonym: "pre-transcriptional gene silencing by small non-coding RNA" NARROW []
synonym: "RNA interference-like chromatin silencing" EXACT []
synonym: "RNA-dependent heterochromatin formation" EXACT []
synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb]
synonym: "RNA-mediated heterochromatin formation" RELATED []
synonym: "RNA-mediated TGS" BROAD []
synonym: "RNA-mediated transcriptional silencing" EXACT []
synonym: "RNAi-directed chromatin silencing" EXACT [GOC:vw]
synonym: "RNAi-like chromatin silencing" EXACT []
synonym: "small ncRNA-mediated heterochromatin formation" NARROW []
synonym: "small non-coding RNA-dependent heterochromatin formation" NARROW []
synonym: "small RNA-mediated heterochromatic silencing" NARROW []
synonym: "small RNA-mediated heterochromatin formation" NARROW []
is_a: GO:0031047 ! regulatory ncRNA-mediated gene silencing
is_a: GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031049
name: programmed DNA elimination
namespace: biological_process
def: "A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing." [GOC:mah, GOC:ns, PMID:18708581, PMID:24886889, PMID:32986476]
subset: goslim_pir
is_a: GO:0010629 ! negative regulation of gene expression

[Term]
id: GO:0031052
name: programmed DNA elimination by chromosome breakage
namespace: biological_process
def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns, PMID:15956677, PMID:25303953, PMID:32165395]
comment: Note that this term refers to breakage of chromosomes during normal DNA well characterized in ciliates but also present in many vertebrates; it is not to be used for DNA damage or other abnormal occurrences.
synonym: "chromosome breakage" RELATED []
is_a: GO:0031049 ! programmed DNA elimination

[Term]
id: GO:0031053
name: primary miRNA processing
namespace: biological_process
alt_id: GO:1990729
alt_id: GO:1990744
def: "A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]
synonym: "pri-miRNA processing" EXACT []
synonym: "primary microRNA processing" EXACT []
synonym: "primary miRNA methylation" NARROW []
synonym: "primary miRNA modification" EXACT []
is_a: GO:0035196 ! miRNA processing

[Term]
id: GO:0031054
name: pre-miRNA processing
namespace: biological_process
def: "A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]
synonym: "pre-microRNA processing" EXACT []
is_a: GO:0035196 ! miRNA processing

[Term]
id: GO:0031055
name: chromatin remodeling at centromere
namespace: biological_process
def: "Dynamic structural changes in centromeric DNA." [GOC:mah]
synonym: "chromatin remodelling at centromere" EXACT []
is_a: GO:0006338 ! chromatin remodeling

[Term]
id: GO:0031056
name: obsolete regulation of histone modification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031057
name: obsolete negative regulation of histone modification
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone modification" EXACT []
synonym: "down-regulation of histone modification" EXACT []
synonym: "downregulation of histone modification" EXACT []
synonym: "inhibition of histone modification" NARROW []
is_obsolete: true
consider: GO:0006338
consider: GO:0040029

[Term]
id: GO:0031058
name: obsolete positive regulation of histone modification
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone modification" NARROW []
synonym: "stimulation of histone modification" NARROW []
synonym: "up regulation of histone modification" EXACT []
synonym: "up-regulation of histone modification" EXACT []
synonym: "upregulation of histone modification" EXACT []
is_obsolete: true
consider: GO:0006338
consider: GO:0040029

[Term]
id: GO:0031059
name: obsolete histone deacetylation at centromere
namespace: biological_process
def: "OBSOLETE. The removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function as a biological process, and contains cellular component information.
is_obsolete: true

[Term]
id: GO:0031060
name: obsolete regulation of histone methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031061
name: obsolete negative regulation of histone methylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone methylation" EXACT []
synonym: "down-regulation of histone methylation" EXACT []
synonym: "downregulation of histone methylation" EXACT []
synonym: "inhibition of histone methylation" NARROW []
is_obsolete: true

[Term]
id: GO:0031062
name: obsolete positive regulation of histone methylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone methylation" NARROW []
synonym: "stimulation of histone methylation" NARROW []
synonym: "up regulation of histone methylation" EXACT []
synonym: "up-regulation of histone methylation" EXACT []
synonym: "upregulation of histone methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0031063
name: obsolete regulation of histone deacetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031064
name: obsolete negative regulation of histone deacetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone deacetylation" EXACT []
synonym: "down-regulation of histone deacetylation" EXACT []
synonym: "downregulation of histone deacetylation" EXACT []
synonym: "inhibition of histone deacetylation" NARROW []
is_obsolete: true

[Term]
id: GO:0031065
name: obsolete positive regulation of histone deacetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone deacetylation" NARROW []
synonym: "stimulation of histone deacetylation" NARROW []
synonym: "up regulation of histone deacetylation" EXACT []
synonym: "up-regulation of histone deacetylation" EXACT []
synonym: "upregulation of histone deacetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0031066
name: obsolete regulation of histone deacetylation at centromere
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function as a biological process, and contains cellular component information.
is_obsolete: true

[Term]
id: GO:0031067
name: obsolete negative regulation of histone deacetylation at centromere
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function as a biological process, and contains cellular component information.
synonym: "down regulation of histone deacetylation at centromere" EXACT []
synonym: "down-regulation of histone deacetylation at centromere" EXACT []
synonym: "downregulation of histone deacetylation at centromere" EXACT []
synonym: "inhibition of histone deacetylation at centromere" NARROW []
is_obsolete: true

[Term]
id: GO:0031068
name: obsolete positive regulation of histone deacetylation at centromere
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function as a biological process, and contains cellular component information.
synonym: "activation of histone deacetylation at centromere" NARROW []
synonym: "stimulation of histone deacetylation at centromere" NARROW []
synonym: "up regulation of histone deacetylation at centromere" EXACT []
synonym: "up-regulation of histone deacetylation at centromere" EXACT []
synonym: "upregulation of histone deacetylation at centromere" EXACT []
is_obsolete: true

[Term]
id: GO:0031069
name: hair follicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0022405 ! hair cycle process
relationship: part_of GO:0001942 ! hair follicle development
relationship: part_of GO:0048730 ! epidermis morphogenesis

[Term]
id: GO:0031070
name: intronic snoRNA processing
namespace: biological_process
def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw]
is_a: GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:0031071
name: cysteine desulfurase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]
synonym: "cysteine desulfurylase activity" RELATED [EC:2.8.1.7]
synonym: "IscS" RELATED [EC:2.8.1.7]
synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" RELATED [EC:2.8.1.7]
synonym: "NIFS" RELATED [EC:2.8.1.7]
synonym: "SufS" RELATED [EC:2.8.1.7]
xref: EC:2.8.1.7
xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster"
xref: Reactome:R-HSA-947514 "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3"
xref: RHEA:43892
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0031072
name: heat shock protein binding
namespace: molecular_function
def: "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031073
name: cholesterol 26-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + H+ NADPH + O2 = 26-hydroxycholesterol + H2O + NADP+." [PMID:950499, RHEA:43836]
xref: RHEA:43836
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0031074
name: nucleocytoplasmic transport complex
namespace: cellular_component
def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "nucleocytoplasmic shuttling complex" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0031076
name: embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "embryonic eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0031077
name: post-embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "post-embryonic camera-style eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0031078
name: histone H3K14 deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [PMID:28450737]
synonym: "histone deacetylase activity (H3-K14 specific)" EXACT []
synonym: "histone H3-K14 deacetylase activity" EXACT []
synonym: "histone H3K14 deacetylase activity" BROAD []
is_a: GO:0141050 ! histone H3K deacetylase activity
is_a: GO:0141221 ! histone deacetylase activity, hydrolytic mechanism

[Term]
id: GO:0031079
name: obsolete picornain 3C activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28]
comment: This term was made obsolete because it represents a gene product.
synonym: "3C protease activity" RELATED [EC:3.4.22.28]
synonym: "3C proteinase activity" RELATED [EC:3.4.22.28]
synonym: "coxsackievirus 3C proteinase activity" RELATED [EC:3.4.22.28]
synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "hepatitis A virus 3C proteinase activity" RELATED [EC:3.4.22.28]
synonym: "picornain 3C activity" EXACT []
synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "protease 3C" RELATED [EC:3.4.22.28]
synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28]
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0031080
name: nuclear pore outer ring
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "Nup107-120 complex" EXACT []
synonym: "Nup107-160 complex" EXACT []
synonym: "Nup84 complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0031082
name: BLOC complex
namespace: cellular_component
def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680]
subset: goslim_pir
synonym: "BLOC-1 related complex" EXACT [PMID:25898167]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0031083
name: BLOC-1 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031084
name: BLOC-2 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031085
name: BLOC-3 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031086
name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
namespace: biological_process
def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544]
synonym: "deadenylation-independent mRNA decay" EXACT []
synonym: "deadenylylation-independent mRNA decay" EXACT []
synonym: "mRNA breakdown, deadenylation-independent decay" EXACT []
synonym: "mRNA catabolic process, deadenylation-independent" EXACT []
synonym: "mRNA catabolic process, deadenylylation-independent" EXACT []
synonym: "mRNA catabolism, deadenylation-independent" EXACT []
synonym: "mRNA catabolism, deadenylation-independent decay" EXACT []
synonym: "mRNA catabolism, deadenylylation-independent" EXACT []
synonym: "mRNA degradation, deadenylation-independent decay" EXACT []
synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0031087
name: deadenylation-independent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]
synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED []
synonym: "deadenylylation-independent decapping" EXACT []
is_a: GO:0110156 ! mRNA methylguanosine-cap decapping
relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

[Term]
id: GO:0031088
name: platelet dense granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031089
name: platelet dense granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah]
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031090
name: organelle membrane
namespace: cellular_component
def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]
synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606]
xref: NIF_Subcellular:sao830981606
is_a: GO:0016020 ! membrane
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031091
name: platelet alpha granule
namespace: cellular_component
def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233]
synonym: "platelet alpha-granule" EXACT []
xref: Wikipedia:Platelet_alpha-granule
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031092
name: platelet alpha granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233]
synonym: "platelet alpha-granule membrane" EXACT []
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031093
name: platelet alpha granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233]
synonym: "platelet alpha-granule lumen" EXACT []
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031094
name: platelet dense tubular network
namespace: cellular_component
def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0031095
name: platelet dense tubular network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031096
name: platelet dense tubular network lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031097
name: medial cortex
namespace: cellular_component
def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789]
synonym: "medial ring" EXACT [GOC:vw]
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0031098
name: stress-activated protein kinase signaling cascade
namespace: biological_process
def: "The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal." [GOC:mah]
synonym: "JNK signaling pathway" NARROW []
synonym: "JNK signalling pathway" NARROW []
synonym: "SAPK signaling pathway" EXACT []
synonym: "SAPK signalling pathway" EXACT []
synonym: "stress-activated protein kinase signaling pathway" EXACT []
synonym: "stress-activated protein kinase signalling pathway" EXACT []
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0031099
name: regeneration
namespace: biological_process
def: "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr]
xref: Wikipedia:Regeneration_(biology)
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0031100
name: animal organ regeneration
namespace: biological_process
def: "The regrowth of a lost or destroyed animal organ." [GOC:mah]
is_a: GO:0031099 ! regeneration
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0031101
name: fin regeneration
namespace: biological_process
def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh]
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0031102
name: neuron projection regeneration
namespace: biological_process
def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "neurite regeneration" NARROW [GOC:mah]
is_a: GO:0031099 ! regeneration
is_a: GO:0031175 ! neuron projection development
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0031103
name: axon regeneration
namespace: biological_process
def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
is_a: GO:0031102 ! neuron projection regeneration
is_a: GO:0048678 ! response to axon injury
is_a: GO:0061564 ! axon development

[Term]
id: GO:0031104
name: dendrite regeneration
namespace: biological_process
def: "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
is_a: GO:0016358 ! dendrite development
is_a: GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0031105
name: septin complex
namespace: cellular_component
def: "A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0031106
name: septin ring organization
namespace: biological_process
def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah]
synonym: "septin ring organisation" EXACT []
is_a: GO:0032185 ! septin cytoskeleton organization

[Term]
id: GO:0031107
name: septin ring disassembly
namespace: biological_process
def: "The controlled breakdown of a septin ring." [GOC:mah]
is_a: GO:0031106 ! septin ring organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0031108
name: holo-[acyl-carrier-protein] biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg]
synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT []
synonym: "holo-[acyl-carrier-protein] anabolism" EXACT []
synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT []
synonym: "holo-[acyl-carrier-protein] formation" EXACT []
synonym: "holo-[acyl-carrier-protein] synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0031109
name: microtubule polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
synonym: "microtubule dynamics" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031110
name: regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031111
name: negative regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "downregulation of microtubule polymerization or depolymerization" EXACT []
synonym: "inhibition of microtubule polymerization or depolymerization" NARROW []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031112
name: positive regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "activation of microtubule polymerization or depolymerization" NARROW []
synonym: "stimulation of microtubule polymerization or depolymerization" NARROW []
synonym: "up regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "upregulation of microtubule polymerization or depolymerization" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031113
name: regulation of microtubule polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah]
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031114
name: regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "regulation of microtubule disassembly" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031115
name: negative regulation of microtubule polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization" EXACT []
synonym: "down-regulation of microtubule polymerization" EXACT []
synonym: "downregulation of microtubule polymerization" EXACT []
synonym: "inhibition of microtubule polymerization" NARROW []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031116
name: positive regulation of microtubule polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "activation of microtubule polymerization" NARROW []
synonym: "stimulation of microtubule polymerization" NARROW []
synonym: "up regulation of microtubule polymerization" EXACT []
synonym: "up-regulation of microtubule polymerization" EXACT []
synonym: "upregulation of microtubule polymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031117
name: positive regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "activation of microtubule depolymerization" NARROW []
synonym: "microtubule destabilization" EXACT []
synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of microtubule disassembly" EXACT []
synonym: "stimulation of microtubule depolymerization" NARROW []
synonym: "up regulation of microtubule depolymerization" EXACT []
synonym: "up-regulation of microtubule depolymerization" EXACT []
synonym: "upregulation of microtubule depolymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901881 ! positive regulation of protein depolymerization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031118
name: rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0001522 ! pseudouridine synthesis

[Term]
id: GO:0031119
name: tRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0031120
name: snRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah]
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0040031 ! snRNA modification

[Term]
id: GO:0031121
name: equatorial microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw]
synonym: "equatorial microtubule organisation" EXACT []
synonym: "equatorial microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031122
name: cytoplasmic microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
synonym: "cytoplasmic microtubule organisation" EXACT []
synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0031123
name: RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]
synonym: "RNA 3' end processing" EXACT []
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0031124
name: mRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]
synonym: "mRNA 3' end processing" EXACT []
is_a: GO:0006397 ! mRNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0031125
name: rRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]
synonym: "rRNA 3' end processing" EXACT []
is_a: GO:0006364 ! rRNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0031126
name: sno(s)RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456]
synonym: "sno(s)RNA 3' end processing" EXACT []
synonym: "snoRNA 3'-end processing" NARROW []
synonym: "sRNA 3'-end processing" NARROW []
is_a: GO:0031123 ! RNA 3'-end processing
is_a: GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:0031127
name: alpha-(1,2)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage." [GOC:mah]
synonym: "alpha-(1->2)-fucosyltransferase activity" EXACT []
synonym: "alpha-1,2-fucosyltransferase activity" EXACT []
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0031128
name: developmental induction
namespace: biological_process
def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0031129
name: inductive cell-cell signaling
namespace: biological_process
def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah]
synonym: "inductive cell-cell signalling" EXACT []
is_a: GO:0031128 ! developmental induction

[Term]
id: GO:0031130
name: obsolete creation of an inductive signal
namespace: biological_process
def: "OBSOLETE. The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah]
comment: The reason for obsoletion is that the term is not clearly defined and there is no annotations.
is_obsolete: true

[Term]
id: GO:0031131
name: obsolete reception of an inductive signal
namespace: biological_process
def: "OBSOLETE. The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah]
comment: The reason for obsoletion is that these are pre-composed terms that represent a cell-surface signaling pathway during some developmental process.
is_obsolete: true

[Term]
id: GO:0031132
name: serine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + NADP+ = L-alpha-formylglycine + 2 H+ + NADPH." [EC:1.1.1.276, RHEA:21596]
synonym: "L-serine:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.276]
xref: EC:1.1.1.276
xref: KEGG_REACTION:R06126
xref: MetaCyc:RXN0-2201
xref: RHEA:21596
xref: Wikipedia:Serine_3-dehydrogenase
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0031133
name: regulation of axon diameter
namespace: biological_process
def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032536 ! regulation of cell projection size
is_a: GO:0050770 ! regulation of axonogenesis

[Term]
id: GO:0031134
name: sister chromatid biorientation
namespace: biological_process
def: "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047]
synonym: "chromosome biorientation" EXACT []
synonym: "sister kinetochore biorientation" EXACT []
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
relationship: part_of GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0031135
name: obsolete negative regulation of conjugation
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate of conjugation." [GOC:mah]
comment: This term was obsoleted because its target (conjugation) was not clearly defined.
synonym: "down regulation of conjugation" EXACT []
synonym: "down-regulation of conjugation" EXACT []
synonym: "downregulation of conjugation" EXACT []
synonym: "inhibition of conjugation" NARROW []
is_obsolete: true

[Term]
id: GO:0031136
name: obsolete positive regulation of conjugation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate or frequency of conjugation." [GOC:mah]
comment: This term was obsoleted because its target (conjugation) was not clearly defined.
synonym: "activation of conjugation" NARROW []
synonym: "stimulation of conjugation" NARROW []
synonym: "up regulation of conjugation" EXACT []
synonym: "up-regulation of conjugation" EXACT []
synonym: "upregulation of conjugation" EXACT []
is_obsolete: true

[Term]
id: GO:0031137
name: regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah]
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031138
name: negative regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah]
synonym: "down regulation of conjugation with cellular fusion" EXACT []
synonym: "down-regulation of conjugation with cellular fusion" EXACT []
synonym: "downregulation of conjugation with cellular fusion" EXACT []
synonym: "inhibition of conjugation with cellular fusion" NARROW []
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031139
name: positive regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of conjugation with cellular fusion" NARROW []
synonym: "stimulation of conjugation with cellular fusion" NARROW []
synonym: "up regulation of conjugation with cellular fusion" EXACT []
synonym: "up-regulation of conjugation with cellular fusion" EXACT []
synonym: "upregulation of conjugation with cellular fusion" EXACT []
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031140
name: induction of conjugation upon nutrient starvation
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah]
is_a: GO:0010514 ! induction of conjugation with cellular fusion

[Term]
id: GO:0031141
name: induction of conjugation upon carbon starvation
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah]
is_a: GO:0031140 ! induction of conjugation upon nutrient starvation

[Term]
id: GO:0031142
name: induction of conjugation upon nitrogen starvation
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0031140 ! induction of conjugation upon nutrient starvation

[Term]
id: GO:0031143
name: pseudopodium
namespace: cellular_component
def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732]
subset: goslim_pir
synonym: "axopodium" NARROW []
synonym: "lobopodium" NARROW []
synonym: "pseudopod" EXACT []
synonym: "pseudopodial protrusion" EXACT []
synonym: "reticulopodium" NARROW []
xref: Wikipedia:Pseudopod
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0031144
name: proteasome localization
namespace: biological_process
def: "Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of proteasome localization" EXACT []
synonym: "proteasome localisation" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0031145
name: anaphase-promoting complex-dependent catabolic process
namespace: biological_process
alt_id: GO:0008054
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT []
synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "cyclin breakdown" NARROW []
synonym: "cyclin catabolic process" NARROW []
synonym: "cyclin catabolism" NARROW []
synonym: "cyclin degradation" NARROW []
synonym: "degradation of cyclin" NARROW []
synonym: "negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation" NARROW []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0031146
name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0031147
name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822]
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT []
synonym: "DIF-1 metabolic process" EXACT []
synonym: "DIF-1 metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0031148
name: DIF-1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822]
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT []
synonym: "DIF-1 biosynthesis" EXACT []
is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0031149
name: sorocarp stalk cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4338436]
synonym: "stalk cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031150 ! sorocarp stalk development

[Term]
id: GO:0031150
name: sorocarp stalk development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [GOC:mtg_sensu, ISBN:0521583640, PMID:4338436]
synonym: "sorophore development" EXACT []
synonym: "stalk development" BROAD []
synonym: "stalk formation" BROAD []
is_a: GO:0099120 ! socially cooperative development
relationship: part_of GO:0031154 ! culmination involved in sorocarp development

[Term]
id: GO:0031151
name: histone H3K79 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351]
synonym: "histone H3K79 methylase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K79 specific)" EXACT []
synonym: "histone methylase activity (H3-K79 specific)" EXACT [GOC:mah]
synonym: "histone methyltransferase activity (H3-K79 specific)" EXACT []
synonym: "histone-H3K79 methyltransferase activity" EXACT []
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0031152
name: aggregation involved in sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "aggregate development involved in sorocarp development" EXACT []
synonym: "aggregation during fruiting body development" EXACT []
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0099120 ! socially cooperative development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031153
name: slug development involved in sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "migratory slug development during sorocarp development" NARROW []
synonym: "pseudoplasmodium biosynthesis" EXACT []
synonym: "pseudoplasmodium formation" EXACT []
synonym: "slug development during fruiting body development" EXACT []
synonym: "slug development during sorocarp development" RELATED [GOC:dph, GOC:tb]
synonym: "standing slug development during sorocarp development" NARROW []
is_a: GO:0099120 ! socially cooperative development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031154
name: culmination involved in sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "culminant development" EXACT []
synonym: "culmination during fruiting body development" EXACT []
synonym: "culmination during sorocarp development" RELATED []
is_a: GO:0099120 ! socially cooperative development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031155
name: regulation of reproductive fruiting body development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reproductive fruiting body development." [GOC:mah]
synonym: "regulation of fruiting body formation" EXACT []
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0030582 ! reproductive fruiting body development

[Term]
id: GO:0031156
name: regulation of sorocarp development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, PMID:4332228]
synonym: "regulation of fruiting body development" BROAD []
synonym: "regulation of fruiting body formation" BROAD []
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0030587 ! sorocarp development

[Term]
id: GO:0031157
name: regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:4338436]
synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED []
synonym: "regulation of aggregation during fruiting body formation" RELATED []
is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031158
name: negative regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:5002049]
synonym: "down regulation of aggregate size" EXACT []
synonym: "down-regulation of aggregate size" EXACT []
synonym: "downregulation of aggregate size" EXACT []
synonym: "inhibition of aggregate size" NARROW []
is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development

[Term]
id: GO:0031159
name: positive regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that increases the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:pg, PMID:5002049]
synonym: "activation of aggregate size" NARROW []
synonym: "stimulation of aggregate size" NARROW []
synonym: "up regulation of aggregate size" EXACT []
synonym: "up-regulation of aggregate size" EXACT []
synonym: "upregulation of aggregate size" EXACT []
is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development

[Term]
id: GO:0031160
name: spore wall
namespace: cellular_component
def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]
synonym: "spore coat" EXACT []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0031161
name: phosphatidylinositol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah]
synonym: "phosphatidylinositol breakdown" EXACT []
synonym: "phosphatidylinositol catabolism" EXACT []
synonym: "phosphatidylinositol degradation" EXACT []
synonym: "PtdIns catabolic process" EXACT []
synonym: "PtdIns catabolism" EXACT []
is_a: GO:0046475 ! glycerophospholipid catabolic process
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0031162
name: obsolete sulfur incorporation into metallo-sulfur cluster
namespace: biological_process
def: "OBSOLETE. The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT []
is_obsolete: true

[Term]
id: GO:0031163
name: metallo-sulfur cluster assembly
namespace: biological_process
def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
synonym: "metal-sulfur cluster assembly" EXACT [GOC:pr]
synonym: "metallo-sulfur cluster biosynthesis" RELATED []
synonym: "metallo-sulphur cluster assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0031164
name: contractile vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg]
synonym: "contractile vacuole membrane" EXACT [GOC:mah, GOC:pf]
is_a: GO:0005774 ! vacuolar membrane
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0000331 ! contractile vacuole

[Term]
id: GO:0031165
name: obsolete integral component of contractile vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:pg]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to contractile vacuolar membrane" EXACT []
is_obsolete: true
replaced_by: GO:0031164

[Term]
id: GO:0031166
name: obsolete integral component of vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to vacuolar membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005774

[Term]
id: GO:0031167
name: rRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0001510 ! RNA methylation

[Term]
id: GO:0031168
name: ferrichrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732]
synonym: "ferrichrome metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0031169
name: ferrichrome biosynthetic process
namespace: biological_process
alt_id: GO:0031199
alt_id: GO:0031200
def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732]
synonym: "ferrichrome anabolism" EXACT []
synonym: "ferrichrome biosynthesis" EXACT []
synonym: "ferrichrome biosynthetic process, peptide formation" NARROW []
synonym: "ferrichrome biosynthetic process, peptide modification" NARROW []
synonym: "ferrichrome formation" EXACT []
synonym: "ferrichrome synthesis" EXACT []
is_a: GO:0019539 ! hydroxymate-containing siderophore biosynthetic process
is_a: GO:0031168 ! ferrichrome metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0031170
name: ferricrocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635]
synonym: "ferricrocin metabolism" EXACT []
is_a: GO:0031168 ! ferrichrome metabolic process

[Term]
id: GO:0031171
name: ferricrocin biosynthetic process
namespace: biological_process
alt_id: GO:0031185
alt_id: GO:0031186
def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635]
synonym: "ferricrocin anabolism" EXACT []
synonym: "ferricrocin biosynthesis" EXACT []
synonym: "ferricrocin biosynthetic process, peptide formation" NARROW []
synonym: "ferricrocin biosynthetic process, peptide modification" NARROW []
synonym: "ferricrocin formation" EXACT []
synonym: "ferricrocin synthesis" EXACT []
is_a: GO:0031169 ! ferrichrome biosynthetic process
is_a: GO:0031170 ! ferricrocin metabolic process

[Term]
id: GO:0031172
name: ornithine N5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635]
synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128]
xref: MetaCyc:RXN-11128
xref: RHEA:41508
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0031173
name: otolith mineralization completed early in development
namespace: biological_process
def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873]
synonym: "otoconia mineralization" EXACT []
synonym: "otoconium mineralization" EXACT []
is_a: GO:0045299 ! otolith mineralization

[Term]
id: GO:0031174
name: lifelong otolith mineralization
namespace: biological_process
def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873]
is_a: GO:0045299 ! otolith mineralization

[Term]
id: GO:0031175
name: neuron projection development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite development" NARROW [GOC:dph]
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite outgrowth" NARROW []
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0031176
name: endo-1,4-beta-xylanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8]
synonym: "1,4-beta-D-xylan xylanohydrolase activity" RELATED [EC:3.2.1.8]
synonym: "1,4-beta-xylan xylanohydrolase activity" RELATED [EC:3.2.1.8]
synonym: "beta-1,4-xylan xylanohydrolase activity" RELATED [EC:3.2.1.8]
synonym: "beta-1,4-xylanase activity" RELATED [EC:3.2.1.8]
synonym: "beta-D-xylanase activity" RELATED [EC:3.2.1.8]
synonym: "beta-xylanase activity" RELATED [EC:3.2.1.8]
synonym: "endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity" RELATED [EC:3.2.1.8]
synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" RELATED [EC:3.2.1.8]
synonym: "endo-1,4-beta-D-xylanase activity" RELATED [EC:3.2.1.8]
synonym: "endo-1,4-xylanase activity" RELATED [EC:3.2.1.8]
synonym: "endo-beta-1,4-xylanase activity" RELATED [EC:3.2.1.8]
synonym: "xylanase" BROAD [EC:3.2.1.8]
xref: EC:3.2.1.8
xref: MetaCyc:3.2.1.8-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0031177
name: phosphopantetheine binding
namespace: molecular_function
def: "Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw]
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033218 ! amide binding
is_a: GO:0072341 ! modified amino acid binding

[Term]
id: GO:0031179
name: peptide modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah]
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0031201
name: SNARE complex
namespace: cellular_component
def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031203
name: post-translational protein targeting to membrane, docking
namespace: biological_process
def: "The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814]
synonym: "posttranslational protein membrane targeting, docking" EXACT []
synonym: "posttranslational protein targeting to membrane, docking" EXACT []
synonym: "protein docking during posttranslational protein targeting to membrane" EXACT []
synonym: "Sec-translated protein complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0006620 ! post-translational protein targeting to endoplasmic reticulum membrane

[Term]
id: GO:0031204
name: post-translational protein targeting to membrane, translocation
namespace: biological_process
def: "The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814]
synonym: "posttranslational protein membrane targeting, translocation" EXACT []
synonym: "posttranslational protein targeting to membrane, translocation" EXACT []
synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0006620 ! post-translational protein targeting to endoplasmic reticulum membrane

[Term]
id: GO:0031205
name: endoplasmic reticulum Sec complex
namespace: cellular_component
def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:14617809]
subset: goslim_pir
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0031207
name: Sec62/Sec63 complex
namespace: cellular_component
def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809]
synonym: "ER protein translocation subcomplex" EXACT []
synonym: "Sec62/63 complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex

[Term]
id: GO:0031208
name: POZ domain binding
namespace: molecular_function
def: "Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
synonym: "broad-complex, tramtrack, and bric-a-brac domain binding" EXACT []
synonym: "BTB domain" EXACT [PMID:22621901]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0031209
name: SCAR complex
namespace: cellular_component
def: "A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101]
synonym: "WAVE complex" EXACT []
synonym: "WAVE regulatory complex" EXACT []
synonym: "WRC" BROAD []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031210
name: phosphatidylcholine binding
namespace: molecular_function
def: "Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0043169 ! cation binding
is_a: GO:0050997 ! quaternary ammonium group binding

[Term]
id: GO:0031211
name: endoplasmic reticulum palmitoyltransferase complex
namespace: cellular_component
def: "A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh]
is_a: GO:0002178 ! palmitoyltransferase complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:0031213
name: RSF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179]
synonym: "remodeling and spacing factor complex" EXACT []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0031214
name: biomineral tissue development
namespace: biological_process
def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736]
xref: Wikipedia:Biomineralization
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0031215
name: shell calcification
namespace: biological_process
def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736]
is_a: GO:0031214 ! biomineral tissue development

[Term]
id: GO:0031216
name: neopullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg]
synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" RELATED [EC:3.2.1.135]
synonym: "pullulanase II activity" EXACT []
xref: EC:3.2.1.135
xref: MetaCyc:3.2.1.135-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0031217
name: glucan 1,4-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg]
synonym: "1,4-beta-D-glucan glucohydrolase activity" BROAD [EC:3.2.1.74]
synonym: "beta-1,4-beta-glucanase activity" BROAD [EC:3.2.1.74]
synonym: "beta-1,4-glucanase activity" BROAD []
synonym: "exo-1,4-beta-D-glucosidase activity" RELATED [EC:3.2.1.74]
synonym: "exo-1,4-beta-glucanase activity" EXACT []
synonym: "exo-1,4-beta-glucosidase activity" EXACT []
synonym: "exo-beta-1,4-glucanase activity" EXACT []
synonym: "exo-beta-1,4-glucosidase activity" EXACT []
synonym: "exocellulase activity" EXACT []
xref: EC:3.2.1.74
xref: MetaCyc:3.2.1.74-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0031218
name: arabinogalactan endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg]
synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" RELATED [EC:3.2.1.89]
synonym: "arabinogalactanase activity" EXACT []
synonym: "endo-1,4-beta-galactanase activity" EXACT []
synonym: "galactanase activity" EXACT []
xref: EC:3.2.1.89
xref: MetaCyc:3.2.1.89-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0031219
name: levanase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg]
synonym: "2,6-beta-D-fructan fructanohydrolase activity" RELATED [EC:3.2.1.65]
synonym: "levan hydrolase activity" EXACT []
xref: EC:3.2.1.65
xref: MetaCyc:3.2.1.65-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0031220
name: maltodextrin phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose." [PMID:10348846, RHEA:29691]
xref: MetaCyc:RXN0-5182
xref: RHEA:29691
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0031221
name: arabinan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732]
synonym: "arabinan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0031222
name: arabinan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732]
synonym: "arabinan breakdown" EXACT []
synonym: "arabinan catabolism" EXACT []
synonym: "arabinan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0031221 ! arabinan metabolic process

[Term]
id: GO:0031223
name: auditory behavior
namespace: biological_process
def: "The behavior of an organism in response to a sound." [GOC:pr, GOC:rc]
synonym: "auditory behaviour" EXACT []
synonym: "behavioral response to sound" EXACT []
synonym: "behavioural response to sound" EXACT []
is_a: GO:0007638 ! mechanosensory behavior
relationship: part_of GO:0010996 ! response to auditory stimulus

[Term]
id: GO:0031224
name: obsolete intrinsic component of membrane
namespace: cellular_component
def: "OBSOLETE. The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to membrane" NARROW []
is_obsolete: true
replaced_by: GO:0016020

[Term]
id: GO:0031225
name: obsolete anchored component of membrane
namespace: cellular_component
def: "OBSOLETE. The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "anchored to membrane" EXACT []
is_obsolete: true
replaced_by: GO:0016020

[Term]
id: GO:0031226
name: obsolete intrinsic component of plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to plasma membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005886

[Term]
id: GO:0031227
name: obsolete intrinsic component of endoplasmic reticulum membrane
namespace: cellular_component
def: "OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to endoplasmic reticulum membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005789

[Term]
id: GO:0031228
name: obsolete intrinsic component of Golgi membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to Golgi membrane" NARROW []
is_obsolete: true
replaced_by: GO:0000139

[Term]
id: GO:0031229
name: obsolete intrinsic component of nuclear inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to nuclear inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005637

[Term]
id: GO:0031230
name: obsolete intrinsic component of cell outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah, GOC:mtg_sensu]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to cell outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009279

[Term]
id: GO:0031231
name: obsolete intrinsic component of peroxisomal membrane
namespace: cellular_component
def: "OBSOLETE. The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to peroxisomal membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005778

[Term]
id: GO:0031232
name: extrinsic component of external side of plasma membrane
namespace: cellular_component
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "extrinsic to external side of plasma membrane" NARROW []
is_a: GO:0019897 ! extrinsic component of plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031233
name: obsolete intrinsic component of external side of plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "intrinsic to external side of plasma membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009897

[Term]
id: GO:0031234
name: extrinsic component of cytoplasmic side of plasma membrane
namespace: cellular_component
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]
comment: Consider also annotating to 'cell cortex ; GO:0005938'.
synonym: "extrinsic to cytoplasmic side of plasma membrane" NARROW []
synonym: "extrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "extrinsic to internal side of plasma membrane" EXACT []
is_a: GO:0019897 ! extrinsic component of plasma membrane
relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane

[Term]
id: GO:0031235
name: obsolete intrinsic component of the cytoplasmic side of the plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to cytoplasmic side of plasma membrane" NARROW []
synonym: "intrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "intrinsic to internal side of plasma membrane" EXACT []
is_obsolete: true
replaced_by: GO:0009898

[Term]
id: GO:0031236
name: extrinsic component of periplasmic side of plasma membrane
namespace: cellular_component
alt_id: GO:0031238
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
synonym: "extrinsic to external leaflet of plasma membrane, in periplasmic space" NARROW [GOC:ab]
synonym: "extrinsic to external side of plasma membrane, in periplasmic space" NARROW []
is_a: GO:0031232 ! extrinsic component of external side of plasma membrane
relationship: part_of GO:0098567 ! periplasmic side of plasma membrane

[Term]
id: GO:0031237
name: obsolete intrinsic component of periplasmic side of plasma membrane
namespace: cellular_component
alt_id: GO:0031239
def: "OBSOLETE. The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:mah, GOC:mtg_sensu]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to external leaflet of plasma membrane, in periplasmic space" EXACT [GOC:ab]
synonym: "intrinsic to periplasmic side of plasma membrane" EXACT []
is_obsolete: true
replaced_by: GO:0098567

[Term]
id: GO:0031240
name: external side of cell outer membrane
namespace: cellular_component
def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
synonym: "external leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "external side of outer membrane" RELATED []
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031241
name: periplasmic side of cell outer membrane
namespace: cellular_component
def: "The side (leaflet) of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
comment: In GO, 'internal side' still refers to part of the membrane and does not refer to components beyond (inside of) the membrane.
synonym: "internal leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "internal side of cell outer membrane" EXACT []
synonym: "internal side of outer membrane" EXACT []
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031242
name: extrinsic component of external side of cell outer membrane
namespace: cellular_component
def: "The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
synonym: "extrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "extrinsic to external side of cell outer membrane" NARROW []
synonym: "extrinsic to external side of outer membrane" EXACT []
is_a: GO:0031244 ! extrinsic component of cell outer membrane
relationship: part_of GO:0031240 ! external side of cell outer membrane

[Term]
id: GO:0031243
name: obsolete intrinsic component of external side of cell outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "intrinsic to external side of cell outer membrane" NARROW []
synonym: "intrinsic to external side of outer membrane" EXACT []
is_obsolete: true
replaced_by: GO:0031240

[Term]
id: GO:0031244
name: extrinsic component of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
synonym: "extrinsic to cell outer membrane" NARROW []
is_a: GO:0019898 ! extrinsic component of membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031245
name: extrinsic component of periplasmic side of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
synonym: "extrinsic to internal leaflet of cell outer membrane" NARROW [GOC:ab]
synonym: "extrinsic to internal side of cell outer membrane" EXACT []
synonym: "extrinsic to internal side of outer membrane" EXACT []
synonym: "extrinsic to periplasmic side of cell outer membrane" EXACT []
is_a: GO:0031244 ! extrinsic component of cell outer membrane
relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane

[Term]
id: GO:0031246
name: obsolete intrinsic component of periplasmic side of cell outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to external side of cell outer membrane" NARROW []
synonym: "intrinsic to internal leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "intrinsic to internal side of cell outer membrane" EXACT []
synonym: "intrinsic to internal side of outer membrane" EXACT []
is_obsolete: true
replaced_by: GO:0031241

[Term]
id: GO:0031247
name: actin rod assembly
namespace: biological_process
def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699]
synonym: "actin rod formation" RELATED [GOC:mah]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0031248
name: protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf]
subset: goslim_pir
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902493 ! acetyltransferase complex

[Term]
id: GO:0031249
name: denatured protein binding
namespace: molecular_function
def: "Binding to a denatured protein." [GOC:mlg]
comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031250
name: anaerobic ribonucleoside-triphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031251
name: PAN complex
namespace: cellular_component
def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]
synonym: "poly(A) nuclease complex" EXACT []
is_a: GO:1905354 ! exoribonuclease complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031252
name: cell leading edge
namespace: cellular_component
def: "The area of a motile cell closest to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "front of cell" EXACT []
synonym: "leading edge of cell" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0031253
name: cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]
synonym: "membrane extension" RELATED []
synonym: "membrane projection" RELATED []
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0031254
name: cell trailing edge
namespace: cellular_component
def: "The area of a motile cell opposite to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "back of cell" EXACT []
synonym: "trailing edge" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0031255
name: lateral part of motile cell
namespace: cellular_component
def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg, GOC:pr]
is_a: GO:0097574 ! lateral part of cell

[Term]
id: GO:0031256
name: leading edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0031257
name: cell trailing edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah]
synonym: "trailing edge membrane" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0031254 ! cell trailing edge

[Term]
id: GO:0031258
name: lamellipodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0030027 ! lamellipodium

[Term]
id: GO:0031259
name: uropod membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah]
synonym: "uropodium membrane" EXACT []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031257 ! cell trailing edge membrane
relationship: part_of GO:0001931 ! uropod

[Term]
id: GO:0031260
name: pseudopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0031143 ! pseudopodium

[Term]
id: GO:0031261
name: DNA replication preinitiation complex
namespace: cellular_component
def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]
synonym: "pre-IC" EXACT []
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0031262
name: Ndc80 complex
namespace: cellular_component
def: "An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]
synonym: "Nuf2-Ndc80 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000940 ! outer kinetochore

[Term]
id: GO:0031263
name: obsolete ATPase-coupled amine transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg]
comment: This term was obsoleted because it corresponds to a wide range of substrates not necessarily transported by the same transporter. See https://en.wikipedia.org/wiki/Amine.
synonym: "amine ABC transporter" NARROW []
synonym: "amine-transporting ATPase activity" EXACT []
synonym: "ATP-dependent amine transporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0031264
name: death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10." [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815]
comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
subset: goslim_pir
synonym: "death receptor-induced signaling complex" EXACT []
synonym: "death receptor-induced signalling complex" EXACT []
synonym: "death-inducing signalling complex" EXACT []
synonym: "DISC" EXACT []
synonym: "DISC protein complex" EXACT []
xref: Wikipedia:Death-inducing_signaling_complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0031265
name: CD95 death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
synonym: "CD95 death-inducing signalling complex" EXACT []
synonym: "CD95 DISC" EXACT []
synonym: "Fas death-inducing signaling complex" EXACT []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031266
name: TRAIL death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
synonym: "TRAIL death-inducing signalling complex" EXACT []
synonym: "TRAIL DISC" EXACT []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031267
name: small GTPase binding
namespace: molecular_function
alt_id: GO:0005084
alt_id: GO:0008536
alt_id: GO:0017016
alt_id: GO:0017031
alt_id: GO:0017048
alt_id: GO:0017049
alt_id: GO:0017137
alt_id: GO:0017160
alt_id: GO:0030306
alt_id: GO:0034989
alt_id: GO:0048365
def: "Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]
synonym: "ADP-ribosylation factor binding" NARROW []
synonym: "ARF binding" NARROW []
synonym: "GTP-Ral binding" NARROW []
synonym: "GTP-Rho binding" NARROW []
synonym: "Rab escort protein activity" NARROW []
synonym: "Rab GTPase binding" NARROW []
synonym: "Rab interactor activity" NARROW []
synonym: "Rac GTPase binding" NARROW []
synonym: "Ral GTPase binding" NARROW []
synonym: "Ran GTPase binding" NARROW []
synonym: "Ran protein binding" NARROW []
synonym: "Ran-binding protein" NARROW []
synonym: "Ras GTPase binding" NARROW []
synonym: "Ras interactor activity" NARROW []
synonym: "REP" NARROW []
synonym: "Rho GTPase binding" NARROW []
is_a: GO:0051020 ! GTPase binding

[Term]
id: GO:0031268
name: pseudopodium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg]
synonym: "pseudopodium organisation" EXACT []
synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0031269
name: pseudopodium assembly
namespace: biological_process
def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb]
synonym: "pseudopodium extension" EXACT []
synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031268 ! pseudopodium organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0031270
name: pseudopodium retraction
namespace: biological_process
def: "The myosin-based contraction and retraction of a pseudopodium." [GOC:pg]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0031268 ! pseudopodium organization

[Term]
id: GO:0031271
name: lateral pseudopodium assembly
namespace: biological_process
def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:dph, GOC:mah, GOC:pg, GOC:tb]
synonym: "lateral pseudopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031272
name: regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "regulation of pseudopodium formation" RELATED []
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031273
name: negative regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "down regulation of pseudopodium formation" RELATED []
synonym: "down-regulation of pseudopodium formation" RELATED []
synonym: "downregulation of pseudopodium formation" RELATED []
synonym: "inhibition of pseudopodium formation" NARROW []
synonym: "negative regulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
relationship: negatively_regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031274
name: positive regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "activation of pseudopodium formation" NARROW []
synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph]
synonym: "stimulation of pseudopodium formation" NARROW []
synonym: "up regulation of pseudopodium formation" RELATED []
synonym: "up-regulation of pseudopodium formation" RELATED []
synonym: "upregulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
relationship: positively_regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031275
name: obsolete regulation of lateral pseudopodium assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
comment: The regulation of lateral pseudopodium assembly terms were not used consistently. The negative regulation term has been replaced by GO:0120320 lateral pseudopodium retraction.
synonym: "regulation of lateral pseudopodium formation" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0031276
name: obsolete negative regulation of lateral pseudopodium assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
comment: The regulation of lateral pseudopodium assembly terms were not used consistently. The negative regulation term has been replaced by GO:0120320 lateral pseudopodium retraction.
synonym: "down regulation of lateral pseudopodium formation" RELATED []
synonym: "down-regulation of lateral pseudopodium formation" RELATED []
synonym: "downregulation of lateral pseudopodium formation" RELATED []
synonym: "inhibition of lateral pseudopodium formation" NARROW []
synonym: "negative regulation of lateral pseudopodium formation" RELATED [GOC:dph]
is_obsolete: true
replaced_by: GO:0120320

[Term]
id: GO:0031277
name: obsolete positive regulation of lateral pseudopodium assembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
comment: The regulation of lateral pseudopodium assembly terms were not used consistently. The negative regulation term has been replaced by GO:0120320 lateral pseudopodium retraction.
synonym: "activation of lateral pseudopodium formation" NARROW []
synonym: "positive regulation of lateral pseudopodium formation" RELATED []
synonym: "stimulation of lateral pseudopodium formation" NARROW []
synonym: "up regulation of lateral pseudopodium formation" RELATED []
synonym: "up-regulation of lateral pseudopodium formation" RELATED []
synonym: "upregulation of lateral pseudopodium formation" RELATED []
is_obsolete: true

[Term]
id: GO:0031278
name: alpha-1,2-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655]
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0031279
name: regulation of cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0031280
name: negative regulation of cyclase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of cyclase activity" EXACT []
synonym: "down-regulation of cyclase activity" EXACT []
synonym: "downregulation of cyclase activity" EXACT []
synonym: "inhibition of cyclase activity" NARROW []
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0043086 ! negative regulation of catalytic activity

[Term]
id: GO:0031281
name: positive regulation of cyclase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a cyclase." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of cyclase activity" NARROW []
synonym: "stimulation of cyclase activity" NARROW []
synonym: "up regulation of cyclase activity" EXACT []
synonym: "up-regulation of cyclase activity" EXACT []
synonym: "upregulation of cyclase activity" EXACT []
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0043085 ! positive regulation of catalytic activity

[Term]
id: GO:0031282
name: regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0051339 ! regulation of lyase activity
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process

[Term]
id: GO:0031283
name: negative regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of guanylate cyclase activity" EXACT []
synonym: "down-regulation of guanylate cyclase activity" EXACT []
synonym: "downregulation of guanylate cyclase activity" EXACT []
synonym: "inhibition of guanylate cyclase activity" NARROW []
is_a: GO:0031280 ! negative regulation of cyclase activity
is_a: GO:0031282 ! regulation of guanylate cyclase activity
is_a: GO:0051350 ! negative regulation of lyase activity
is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process

[Term]
id: GO:0031284
name: positive regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of guanylate cyclase activity" NARROW []
synonym: "stimulation of guanylate cyclase activity" NARROW []
synonym: "up regulation of guanylate cyclase activity" EXACT []
synonym: "up-regulation of guanylate cyclase activity" EXACT []
synonym: "upregulation of guanylate cyclase activity" EXACT []
is_a: GO:0031281 ! positive regulation of cyclase activity
is_a: GO:0031282 ! regulation of guanylate cyclase activity
is_a: GO:0051349 ! positive regulation of lyase activity
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process

[Term]
id: GO:0031285
name: regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436]
synonym: "regulation of stalk cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031286
name: negative regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436]
synonym: "down regulation of stalk cell differentiation" EXACT []
synonym: "down-regulation of stalk cell differentiation" EXACT []
synonym: "downregulation of stalk cell differentiation" EXACT []
synonym: "inhibition of stalk cell differentiation" NARROW []
synonym: "negative regulation of stalk cell differentiation" EXACT []
is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031287
name: positive regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436]
synonym: "activation of stalk cell differentiation" NARROW []
synonym: "positive regulation of stalk cell differentiation" EXACT []
synonym: "stimulation of stalk cell differentiation" NARROW []
synonym: "up regulation of stalk cell differentiation" EXACT []
synonym: "up-regulation of stalk cell differentiation" EXACT []
synonym: "upregulation of stalk cell differentiation" EXACT []
is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031288
name: sorocarp morphogenesis
namespace: biological_process
def: "The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4332228]
synonym: "fruiting body morphogenesis" BROAD [DDANAT:0000012]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031289
name: obsolete actin phosphorylation
namespace: biological_process
def: "OBSOLETE. The transfer of one or more phosphate groups to an actin molecule." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031290
name: retinal ganglion cell axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
synonym: "retinal ganglion cell axon pathfinding" EXACT []
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0031291
name: Ran protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the Ran subfamily relays a signal." [GOC:mah]
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0031293
name: membrane protein intracellular domain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018]
synonym: "membrane protein solubilization" RELATED []
is_a: GO:0033619 ! membrane protein proteolysis

[Term]
id: GO:0031294
name: lymphocyte costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149]
synonym: "lymphocyte co-stimulation" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0051251 ! positive regulation of lymphocyte activation

[Term]
id: GO:0031295
name: T cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149]
synonym: "T cell co-stimulation" EXACT []
synonym: "T lymphocyte costimulation" EXACT []
synonym: "T-cell co-stimulation" EXACT []
synonym: "T-cell costimulation" EXACT []
synonym: "T-lymphocyte costimulation" EXACT []
is_a: GO:0031294 ! lymphocyte costimulation
is_a: GO:0050870 ! positive regulation of T cell activation

[Term]
id: GO:0031296
name: B cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149]
synonym: "B cell co-stimulation" EXACT []
synonym: "B lymphocyte co-stimulation" EXACT []
synonym: "B lymphocyte costimulation" EXACT []
synonym: "B-cell co-stimulation" EXACT []
synonym: "B-cell costimulation" EXACT []
synonym: "B-lymphocyte co-stimulation" EXACT []
synonym: "B-lymphocyte costimulation" EXACT []
is_a: GO:0031294 ! lymphocyte costimulation
is_a: GO:0050871 ! positive regulation of B cell activation

[Term]
id: GO:0031297
name: replication fork processing
namespace: biological_process
alt_id: GO:0034065
def: "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]
synonym: "collapsed replication fork processing" EXACT []
synonym: "recovery from replication fork arrest" EXACT []
synonym: "recovery from replication fork arrest at rDNA locus" NARROW []
synonym: "recovery from replication fork stalling" EXACT []
synonym: "recovery from replication fork stalling at rDNA locus" NARROW []
synonym: "replication fork processing at rDNA locus" NARROW []
synonym: "replication fork processing at ribosomal DNA locus" NARROW []
synonym: "replication fork restart" RELATED [PMID:20842177]
synonym: "replication restart" RELATED [GOC:bhm, PMID:15780929]
is_a: GO:0045005 ! DNA-templated DNA replication maintenance of fidelity

[Term]
id: GO:0031298
name: replication fork protection complex
namespace: cellular_component
def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656]
synonym: "replisome progression complex" EXACT [GOC:vw]
synonym: "Swi1-Swi3 complex" NARROW []
synonym: "TIMELESS-TIPIN complex" NARROW [GOC:mah, GOC:vw]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043596 ! nuclear replication fork

[Term]
id: GO:0031299
name: taurine-pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde." [PMID:11082195, RHEA:10420]
synonym: "taurine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.77]
synonym: "Tpa" RELATED [EC:2.6.1.77]
xref: EC:2.6.1.77
xref: KEGG_REACTION:R05652
xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN
xref: RHEA:10420
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0031300
name: obsolete intrinsic component of organelle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to organelle membrane" NARROW []
is_obsolete: true
replaced_by: GO:0031090

[Term]
id: GO:0031301
name: obsolete integral component of organelle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to organelle membrane" EXACT []
is_obsolete: true
replaced_by: GO:0031090

[Term]
id: GO:0031302
name: obsolete intrinsic component of endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to endosome membrane" NARROW []
is_obsolete: true
replaced_by: GO:0010008

[Term]
id: GO:0031303
name: obsolete integral component of endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to endosome membrane" NARROW []
is_obsolete: true
replaced_by: GO:0010008

[Term]
id: GO:0031304
name: obsolete intrinsic component of mitochondrial inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to mitochondrial inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005743

[Term]
id: GO:0031305
name: obsolete integral component of mitochondrial inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to mitochondrial inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005743

[Term]
id: GO:0031306
name: obsolete intrinsic component of mitochondrial outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to mitochondrial outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005741

[Term]
id: GO:0031307
name: obsolete integral component of mitochondrial outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to mitochondrial outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005741

[Term]
id: GO:0031308
name: obsolete intrinsic component of nuclear outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to nuclear outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005640

[Term]
id: GO:0031309
name: obsolete integral component of nuclear outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to nuclear outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005640

[Term]
id: GO:0031310
name: obsolete intrinsic component of vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to vacuolar membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005774

[Term]
id: GO:0031311
name: obsolete intrinsic component of contractile vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to contractile vacuolar membrane" NARROW []
is_obsolete: true
replaced_by: GO:0031164

[Term]
id: GO:0031312
name: extrinsic component of organelle membrane
namespace: cellular_component
def: "The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to organelle membrane" NARROW []
is_a: GO:0019898 ! extrinsic component of membrane
relationship: part_of GO:0031090 ! organelle membrane
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0031313
name: extrinsic component of endosome membrane
namespace: cellular_component
def: "The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to endosome membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031314
name: extrinsic component of mitochondrial inner membrane
namespace: cellular_component
def: "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to mitochondrial inner membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031315
name: extrinsic component of mitochondrial outer membrane
namespace: cellular_component
def: "The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to mitochondrial outer membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0031316
name: extrinsic component of nuclear outer membrane
namespace: cellular_component
def: "The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to nuclear outer membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031317
name: tripartite ATP-independent periplasmic transporter complex
namespace: cellular_component
def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg]
synonym: "TRAP transporter complex" EXACT []
synonym: "TRAP-T transporter complex" EXACT []
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:0031318
name: detection of folic acid
namespace: biological_process
def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg]
synonym: "detection of folate" EXACT []
synonym: "folate detection" EXACT []
synonym: "folate sensing" EXACT []
synonym: "folic acid detection" EXACT []
synonym: "folic acid sensing" EXACT []
is_a: GO:0009594 ! detection of nutrient
is_a: GO:0051593 ! response to folic acid

[Term]
id: GO:0031319
name: detection of cAMP
namespace: biological_process
def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg]
synonym: "3',5'-cAMP detection" EXACT []
synonym: "3',5'-cAMP sensing" EXACT []
synonym: "cAMP detection" EXACT []
synonym: "cAMP sensing" EXACT []
synonym: "cyclic AMP detection" EXACT []
synonym: "detection of 3',5' cAMP" EXACT []
synonym: "detection of 3',5'-cAMP" EXACT []
synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT []
synonym: "detection of cyclic AMP" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051591 ! response to cAMP

[Term]
id: GO:0031320
name: hexitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah]
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0031321
name: ascospore-type prospore assembly
namespace: biological_process
def: "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385]
synonym: "ascospore-type prospore formation" EXACT []
synonym: "forespore formation" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0030437 ! ascospore formation

[Term]
id: GO:0031322
name: ascospore-type prospore-specific spindle pole body remodeling
namespace: biological_process
def: "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385]
synonym: "ascospore-type prospore-specific spindle pole body modification" RELATED [GOC:vw]
synonym: "ascospore-type prospore-specific spindle pole body remodelling" EXACT [GOC:mah]
synonym: "forespore specific spindle pole body remodeling" EXACT []
synonym: "forespore-specific spindle pole body remodeling" EXACT []
synonym: "prospore-specific spindle pole body remodeling" EXACT []
synonym: "sporulation-specific spindle pole body remodeling" EXACT []
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0031321 ! ascospore-type prospore assembly

[Term]
id: GO:0031323
name: obsolete regulation of cellular metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
comment: The reason for obsoletion is that this term is redundant to GO:0019222, regulation of metabolic process
synonym: "regulation of cellular metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0019222

[Term]
id: GO:0031324
name: obsolete negative regulation of cellular metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
comment: The reason for obsoletion is that term is redundant to GO:0009892, negative regulation of metabolic process
synonym: "down regulation of cellular metabolic process" EXACT []
synonym: "down-regulation of cellular metabolic process" EXACT []
synonym: "downregulation of cellular metabolic process" EXACT []
synonym: "inhibition of cellular metabolic process" NARROW []
synonym: "negative regulation of cellular metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0009892

[Term]
id: GO:0031325
name: obsolete positive regulation of cellular metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
comment: The reason for obsoletion is that this term is redundant to GO:0009893
synonym: "activation of cellular metabolic process" NARROW []
synonym: "positive regulation of cellular metabolism" EXACT []
synonym: "stimulation of cellular metabolic process" NARROW []
synonym: "up regulation of cellular metabolic process" EXACT []
synonym: "up-regulation of cellular metabolic process" EXACT []
synonym: "upregulation of cellular metabolic process" EXACT []
is_obsolete: true
replaced_by: GO:0009893

[Term]
id: GO:0031326
name: obsolete regulation of cellular biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
comment: The reason for obsoletion is that this term is now redundant with GO:0009889, regulation of biosynthetic process
synonym: "regulation of cellular anabolism" EXACT []
synonym: "regulation of cellular biosynthesis" EXACT []
synonym: "regulation of cellular formation" EXACT []
synonym: "regulation of cellular synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0009889

[Term]
id: GO:0031327
name: obsolete negative regulation of cellular biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
comment: The reason for obsoletion is that this term is now redundant with GO:0009890, negative regulation of biosynthetic process
synonym: "down regulation of cellular biosynthetic process" EXACT []
synonym: "down-regulation of cellular biosynthetic process" EXACT []
synonym: "downregulation of cellular biosynthetic process" EXACT []
synonym: "inhibition of cellular biosynthetic process" NARROW []
synonym: "negative regulation of cellular anabolism" EXACT []
synonym: "negative regulation of cellular biosynthesis" EXACT []
synonym: "negative regulation of cellular formation" EXACT []
synonym: "negative regulation of cellular synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0009890

[Term]
id: GO:0031328
name: obsolete positive regulation of cellular biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
comment: The reason for this obsoletion is that this term is now redundant to GO:0009892, positive regulation of biosynthetic process
synonym: "activation of cellular biosynthetic process" NARROW []
synonym: "positive regulation of cellular anabolism" EXACT []
synonym: "positive regulation of cellular biosynthesis" EXACT []
synonym: "positive regulation of cellular formation" EXACT []
synonym: "positive regulation of cellular synthesis" EXACT []
synonym: "stimulation of cellular biosynthetic process" NARROW []
synonym: "up regulation of cellular biosynthetic process" EXACT []
synonym: "up-regulation of cellular biosynthetic process" EXACT []
synonym: "upregulation of cellular biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0009891

[Term]
id: GO:0031329
name: obsolete regulation of cellular catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
comment: The reason for obsoletion is that this term is now redundant with GO:0009894, regulation of catabolic process.
synonym: "regulation of cellular breakdown" EXACT []
synonym: "regulation of cellular catabolism" EXACT []
synonym: "regulation of cellular degradation" EXACT []
is_obsolete: true
replaced_by: GO:0009894

[Term]
id: GO:0031330
name: obsolete negative regulation of cellular catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
comment: The reason for obsoletion is that this term is redundant with GO:0009895, negative regulation of catabolic process.
synonym: "down regulation of cellular catabolic process" EXACT []
synonym: "down-regulation of cellular catabolic process" EXACT []
synonym: "downregulation of cellular catabolic process" EXACT []
synonym: "inhibition of cellular catabolic process" NARROW []
synonym: "negative regulation of cellular breakdown" EXACT []
synonym: "negative regulation of cellular catabolism" EXACT []
synonym: "negative regulation of cellular degradation" EXACT []
is_obsolete: true
replaced_by: GO:0009895

[Term]
id: GO:0031331
name: obsolete positive regulation of cellular catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
comment: The reason for obsoletion is that this term is redundant to GO:0009896, postiive regulation of catabolic process
synonym: "activation of cellular catabolic process" NARROW []
synonym: "positive regulation of cellular breakdown" EXACT []
synonym: "positive regulation of cellular catabolism" EXACT []
synonym: "positive regulation of cellular degradation" EXACT []
synonym: "stimulation of cellular catabolic process" NARROW []
synonym: "up regulation of cellular catabolic process" EXACT []
synonym: "up-regulation of cellular catabolic process" EXACT []
synonym: "upregulation of cellular catabolic process" EXACT []
is_obsolete: true
replaced_by: GO:0009896

[Term]
id: GO:0031332
name: RNAi effector complex
namespace: cellular_component
def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433]
subset: goslim_pir
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0031333
name: negative regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]
synonym: "down regulation of protein complex assembly" EXACT []
synonym: "down-regulation of protein complex assembly" EXACT []
synonym: "downregulation of protein complex assembly" EXACT []
synonym: "inhibition of protein complex assembly" NARROW []
synonym: "negative regulation of protein complex assembly" RELATED []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0031334
name: positive regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]
synonym: "activation of protein complex assembly" NARROW []
synonym: "positive regulation of protein complex assembly" RELATED []
synonym: "stimulation of protein complex assembly" NARROW []
synonym: "up regulation of protein complex assembly" EXACT []
synonym: "up-regulation of protein complex assembly" EXACT []
synonym: "upregulation of protein complex assembly" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0031335
name: regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
synonym: "regulation of sulfur amino acid metabolism" EXACT []
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031336
name: negative regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
synonym: "down regulation of sulfur amino acid metabolic process" EXACT []
synonym: "down-regulation of sulfur amino acid metabolic process" EXACT []
synonym: "downregulation of sulfur amino acid metabolic process" EXACT []
synonym: "inhibition of sulfur amino acid metabolic process" NARROW []
synonym: "negative regulation of sulfur amino acid metabolism" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031337
name: positive regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
synonym: "activation of sulfur amino acid metabolic process" NARROW []
synonym: "positive regulation of sulfur amino acid metabolism" EXACT []
synonym: "stimulation of sulfur amino acid metabolic process" NARROW []
synonym: "up regulation of sulfur amino acid metabolic process" EXACT []
synonym: "up-regulation of sulfur amino acid metabolic process" EXACT []
synonym: "upregulation of sulfur amino acid metabolic process" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031338
name: regulation of vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031339
name: negative regulation of vesicle fusion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "down regulation of vesicle fusion" EXACT []
synonym: "down-regulation of vesicle fusion" EXACT []
synonym: "downregulation of vesicle fusion" EXACT []
synonym: "inhibition of vesicle fusion" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031340
name: positive regulation of vesicle fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "activation of vesicle fusion" NARROW []
synonym: "stimulation of vesicle fusion" NARROW []
synonym: "up regulation of vesicle fusion" EXACT []
synonym: "up-regulation of vesicle fusion" EXACT []
synonym: "upregulation of vesicle fusion" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031341
name: regulation of cell killing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0001906 ! cell killing

[Term]
id: GO:0031342
name: negative regulation of cell killing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah]
synonym: "down regulation of cell killing" EXACT []
synonym: "down-regulation of cell killing" EXACT []
synonym: "downregulation of cell killing" EXACT []
synonym: "inhibition of cell killing" NARROW []
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0001906 ! cell killing

[Term]
id: GO:0031343
name: positive regulation of cell killing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah]
synonym: "activation of cell killing" NARROW []
synonym: "stimulation of cell killing" NARROW []
synonym: "up regulation of cell killing" EXACT []
synonym: "up-regulation of cell killing" EXACT []
synonym: "upregulation of cell killing" EXACT []
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0001906 ! cell killing

[Term]
id: GO:0031344
name: regulation of cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "regulation of cell projection organisation" EXACT []
synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031345
name: negative regulation of cell projection organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "down regulation of cell projection organization" EXACT [GOC:mah]
synonym: "down-regulation of cell projection organization" EXACT []
synonym: "downregulation of cell projection organization" EXACT []
synonym: "inhibition of cell projection organization" NARROW []
synonym: "negative regulation of cell projection organisation" EXACT []
synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031346
name: positive regulation of cell projection organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "activation of cell projection organization" NARROW []
synonym: "positive regulation of cell projection organisation" EXACT []
synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell projection organization" NARROW []
synonym: "up regulation of cell projection organization" EXACT []
synonym: "up-regulation of cell projection organization" EXACT []
synonym: "upregulation of cell projection organization" EXACT []
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031347
name: regulation of defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0006952 ! defense response

[Term]
id: GO:0031348
name: negative regulation of defense response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "down regulation of defense response" EXACT []
synonym: "down-regulation of defense response" EXACT []
synonym: "downregulation of defense response" EXACT []
synonym: "inhibition of defense response" NARROW []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031349
name: positive regulation of defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "activation of defense response" NARROW []
synonym: "stimulation of defense response" NARROW []
synonym: "up regulation of defense response" EXACT []
synonym: "up-regulation of defense response" EXACT []
synonym: "upregulation of defense response" EXACT []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031350
name: obsolete intrinsic component of plastid membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to plastid membrane" NARROW []
is_obsolete: true
replaced_by: GO:0042170

[Term]
id: GO:0031351
name: obsolete integral component of plastid membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to plastid membrane" NARROW []
is_obsolete: true
replaced_by: GO:0042170

[Term]
id: GO:0031352
name: obsolete intrinsic component of plastid inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to plastid inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009528

[Term]
id: GO:0031353
name: obsolete integral component of plastid inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to plastid inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009528

[Term]
id: GO:0031354
name: obsolete intrinsic component of plastid outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to plastid outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009527

[Term]
id: GO:0031355
name: obsolete integral component of plastid outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to plastid outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009527

[Term]
id: GO:0031356
name: obsolete intrinsic component of chloroplast inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to chloroplast inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009706

[Term]
id: GO:0031357
name: obsolete integral component of chloroplast inner membrane
namespace: cellular_component
def: "OBSOLETE. The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to chloroplast inner membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009706

[Term]
id: GO:0031358
name: obsolete intrinsic component of chloroplast outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to chloroplast outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009707

[Term]
id: GO:0031359
name: obsolete integral component of chloroplast outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to chloroplast outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009707

[Term]
id: GO:0031360
name: obsolete intrinsic component of thylakoid membrane
namespace: cellular_component
def: "OBSOLETE. The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to thylakoid membrane" NARROW []
is_obsolete: true
replaced_by: GO:0042651

[Term]
id: GO:0031361
name: obsolete integral component of thylakoid membrane
namespace: cellular_component
def: "OBSOLETE. The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to thylakoid membrane" NARROW []
is_obsolete: true
replaced_by: GO:0042651

[Term]
id: GO:0031362
name: obsolete anchored component of external side of plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "anchored to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "anchored to external side of plasma membrane" EXACT []
is_obsolete: true
replaced_by: GO:0009897

[Term]
id: GO:0031363
name: N-terminal protein amino acid deamination
namespace: biological_process
def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0031364
name: N-terminal protein amino acid deamination, from side chain
namespace: biological_process
def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0031363 ! N-terminal protein amino acid deamination

[Term]
id: GO:0031365
name: N-terminal protein amino acid modification
namespace: biological_process
alt_id: GO:0018409
def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "peptide or protein amino-terminal blocking" RELATED []
synonym: "peptide/protein amino-terminal blocking" RELATED []
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0031366
name: obsolete N-terminal peptidyl-asparagine deamination
namespace: biological_process
def: "OBSOLETE. The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:bf, GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031367
name: obsolete N-terminal peptidyl-glutamine deamination
namespace: biological_process
def: "OBSOLETE. The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0031368
name: obsolete Pro-X metallocarboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "Pro-X metallocarboxypeptidase activity" EXACT []
is_obsolete: true
consider: GO:0004181
consider: GO:0008233

[Term]
id: GO:0031369
name: translation initiation factor binding
namespace: molecular_function
def: "Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031370
name: eukaryotic initiation factor 4G binding
namespace: molecular_function
def: "Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
synonym: "eIF4G binding" EXACT []
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0031371
name: ubiquitin conjugating enzyme complex
namespace: cellular_component
def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah]
subset: goslim_pir
synonym: "E2 complex" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0031372
name: UBC13-MMS2 complex
namespace: cellular_component
def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains. In Saccharomyces cerevisiae, the complex comprises Ubc13p and Mms2p; in human it comprises UBE2N and UBE2V1/UBE2V2; and in plants UBC35/UBC36 and UEV1A/UEV1B/UEV1C/UEV1D-4." [GOC:sjm, PMID:15772086, PMID:16129784]
synonym: "BEN-UEV1A complex" EXACT []
synonym: "ubc-13-uev-1 complex" NARROW []
synonym: "UBE2N/UBE2NL complex" NARROW []
synonym: "UBE2V1/UBE2V2 complex" NARROW []
synonym: "Uev1A-ben complex" NARROW []
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex

[Term]
id: GO:0031375
name: obsolete type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
comment: Type II refers to the type of fatty acid synthase. Type I is in a complex, type II is not.
synonym: "type II FAS" EXACT []
synonym: "type II FAS complex" EXACT []
synonym: "type II fatty acid synthase" EXACT []
synonym: "type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031376
name: obsolete cytosolic type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
synonym: "cytosolic type II FAS complex" EXACT []
synonym: "cytosolic type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031377
name: obsolete mitochondrial type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
comment: Obsoleted because type II fatty acid synthases are not complexes
synonym: "mitochondrial type II FAS complex" EXACT []
synonym: "mitochondrial type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031378
name: obsolete plastid type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
comment: Obsoleted because type II fatty acid synthase is not a complex.
synonym: "plastid type II FAS complex" EXACT []
synonym: "plastid type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031379
name: RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0031380
name: nuclear RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]
synonym: "Rdr1 complex" NARROW []
synonym: "RDRC" EXACT []
is_a: GO:0031379 ! RNA-directed RNA polymerase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0031381
name: viral RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301]
is_a: GO:0031379 ! RNA-directed RNA polymerase complex

[Term]
id: GO:0031382
name: mating projection formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532]
synonym: "mating projection assembly" EXACT []
synonym: "mating projection biogenesis" RELATED [GOC:mah]
synonym: "shmooing" NARROW []
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
relationship: part_of GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion

[Term]
id: GO:0031383
name: regulation of mating projection assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532]
synonym: "regulation of mating projection biogenesis" RELATED [GOC:mah]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: regulates GO:0031382 ! mating projection formation

[Term]
id: GO:0031384
name: regulation of initiation of mating projection growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532]
is_a: GO:0031383 ! regulation of mating projection assembly

[Term]
id: GO:0031385
name: regulation of termination of mating projection growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532]
is_a: GO:0031383 ! regulation of mating projection assembly

[Term]
id: GO:0031386
name: protein tag activity
namespace: molecular_function
def: "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]
comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
synonym: "covalent modifier" BROAD [GOC:vw]
synonym: "protein tag" EXACT []
synonym: "protein tagging activity" RELATED []
synonym: "ubiquitin" RELATED []
synonym: "ubiquitin-like protein modifier" EXACT []
is_a: GO:0141047 ! molecular tag activity

[Term]
id: GO:0031387
name: MPF complex
namespace: cellular_component
def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0031388
name: organic acid phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah]
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0031389
name: Rad17 RFC-like complex
namespace: cellular_component
def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842]
synonym: "Rad17-RFC" EXACT []
synonym: "Rad17-RLC" EXACT []
synonym: "Rad24p RFC-like complex" EXACT []
synonym: "RFC (Rad17)" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0031390
name: Ctf18 RFC-like complex
namespace: cellular_component
def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842]
synonym: "Ctf18-RFC" EXACT []
synonym: "Ctf18-RLC" EXACT []
synonym: "RFC (Ctf18)" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0031391
name: Elg1 RFC-like complex
namespace: cellular_component
def: "A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842, PMID:23499004, PMID:27664980]
synonym: "Elg1-RFC" EXACT []
synonym: "Elg1-RLC" EXACT []
synonym: "RFC (Elg1)" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0031392
name: regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "regulation of prostaglandin anabolism" EXACT []
synonym: "regulation of prostaglandin biosynthesis" EXACT []
synonym: "regulation of prostaglandin formation" EXACT []
synonym: "regulation of prostaglandin synthesis" EXACT []
is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process
relationship: regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031393
name: negative regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "down regulation of prostaglandin biosynthetic process" EXACT []
synonym: "down-regulation of prostaglandin biosynthetic process" EXACT []
synonym: "downregulation of prostaglandin biosynthetic process" EXACT []
synonym: "inhibition of prostaglandin biosynthetic process" NARROW []
synonym: "negative regulation of prostaglandin anabolism" EXACT []
synonym: "negative regulation of prostaglandin biosynthesis" EXACT []
synonym: "negative regulation of prostaglandin formation" EXACT []
synonym: "negative regulation of prostaglandin synthesis" EXACT []
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031394
name: positive regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "activation of prostaglandin biosynthetic process" NARROW []
synonym: "positive regulation of prostaglandin anabolism" EXACT []
synonym: "positive regulation of prostaglandin biosynthesis" EXACT []
synonym: "positive regulation of prostaglandin formation" EXACT []
synonym: "positive regulation of prostaglandin synthesis" EXACT []
synonym: "stimulation of prostaglandin biosynthetic process" NARROW []
synonym: "up regulation of prostaglandin biosynthetic process" EXACT []
synonym: "up-regulation of prostaglandin biosynthetic process" EXACT []
synonym: "upregulation of prostaglandin biosynthetic process" EXACT []
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:2001280 ! positive regulation of unsaturated fatty acid biosynthetic process
relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031395
name: bursicon neuropeptide hormone complex
namespace: cellular_component
def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0031396
name: regulation of protein ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031397
name: negative regulation of protein ubiquitination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
synonym: "down regulation of protein ubiquitination" EXACT []
synonym: "down-regulation of protein ubiquitination" EXACT []
synonym: "downregulation of protein ubiquitination" EXACT []
synonym: "inhibition of protein ubiquitination" NARROW []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
relationship: negatively_regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031398
name: positive regulation of protein ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
synonym: "activation of protein ubiquitination" NARROW []
synonym: "stimulation of protein ubiquitination" NARROW []
synonym: "up regulation of protein ubiquitination" EXACT []
synonym: "up-regulation of protein ubiquitination" EXACT []
synonym: "upregulation of protein ubiquitination" EXACT []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
relationship: positively_regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031399
name: regulation of protein modification process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: goslim_yeast
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0036211 ! protein modification process

[Term]
id: GO:0031400
name: negative regulation of protein modification process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein modification" EXACT []
synonym: "down-regulation of protein modification" EXACT []
synonym: "downregulation of protein modification" EXACT []
synonym: "inhibition of protein modification" NARROW []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0036211 ! protein modification process

[Term]
id: GO:0031401
name: positive regulation of protein modification process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein modification" NARROW []
synonym: "stimulation of protein modification" NARROW []
synonym: "up regulation of protein modification" EXACT []
synonym: "up-regulation of protein modification" EXACT []
synonym: "upregulation of protein modification" EXACT []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0036211 ! protein modification process

[Term]
id: GO:0031402
name: sodium ion binding
namespace: molecular_function
def: "Binding to a sodium ion (Na+)." [GOC:mah]
synonym: "Na+ ion binding" EXACT []
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0031403
name: lithium ion binding
namespace: molecular_function
def: "Binding to a lithium ion (Li+)." [GOC:mah]
synonym: "Li+ ion binding" EXACT []
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0031404
name: chloride ion binding
namespace: molecular_function
def: "Binding to a chloride ion (Cl-)." [GOC:mah]
synonym: "chloride binding" EXACT []
synonym: "Cl- ion binding" EXACT []
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0031405
name: lipoic acid binding
namespace: molecular_function
def: "Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732]
is_a: GO:0005504 ! fatty acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0031406
name: carboxylic acid binding
namespace: molecular_function
def: "Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0043168 ! anion binding
is_a: GO:0043177 ! organic acid binding

[Term]
id: GO:0031407
name: oxylipin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741]
synonym: "oxylipin metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0031408
name: oxylipin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741]
synonym: "oxylipin anabolism" EXACT []
synonym: "oxylipin biosynthesis" EXACT []
synonym: "oxylipin formation" EXACT []
synonym: "oxylipin synthesis" EXACT []
is_a: GO:0031407 ! oxylipin metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0031409
name: pigment binding
namespace: molecular_function
def: "Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0031410
name: cytoplasmic vesicle
namespace: cellular_component
alt_id: GO:0016023
def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_mouse
subset: goslim_yeast
synonym: "cytoplasmic membrane bounded vesicle" RELATED []
synonym: "cytoplasmic membrane-enclosed vesicle" RELATED []
synonym: "cytoplasmic, membrane-bounded vesicle" RELATED []
xref: NIF_Subcellular:sao180601769
is_a: GO:0097708 ! intracellular vesicle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031411
name: gas vesicle
namespace: cellular_component
def: "An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations." [PMID:22147705, PMID:8177173]
comment: Note that although this organelle is commonly referred to as a 'vesicle' or 'vacuole' in the literature, it is not surrounded by a membrane.
synonym: "gas vacuole" RELATED [GOC:pr]
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0031412
name: gas vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah]
comment: Note that although gas vesicles are commonly referred to as 'vesicles' or 'vacuoles' in the literature, they are not surrounded by a membrane.
synonym: "gas vesicle biosynthesis" NARROW [GOC:mah]
synonym: "gas vesicle formation" NARROW [GOC:mah]
synonym: "gas vesicle organisation" EXACT []
synonym: "gas vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0031413
name: regulation of buoyancy
namespace: biological_process
def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420]
synonym: "buoyancy regulation" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0031414
name: N-terminal protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah]
synonym: "NAT complex" EXACT []
is_a: GO:0031248 ! protein acetyltransferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031415
name: NatA complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471]
synonym: "N-terminal acetyltransferase A complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031416
name: NatB complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]
synonym: "N-terminal acetyltransferase B complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031417
name: NatC complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]
synonym: "N-terminal acetyltransferase C complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031418
name: L-ascorbic acid binding
namespace: molecular_function
def: "Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]
synonym: "L-ascorbate binding" EXACT []
synonym: "vitamin C binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0048029 ! monosaccharide binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0031419
name: cobalamin binding
namespace: molecular_function
def: "Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]
synonym: "vitamin B12 binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0046906 ! tetrapyrrole binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0031420
name: alkali metal ion binding
namespace: molecular_function
def: "Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah]
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0031421
name: invertasome
namespace: cellular_component
def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0031422
name: RecQ family helicase-topoisomerase III complex
namespace: cellular_component
def: "A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]
synonym: "RecQ helicase-Topo III complex" EXACT [PMID:15889139]
synonym: "Sgs1-Top3 complex" NARROW [PMID:15889139]
is_a: GO:0033202 ! DNA helicase complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0031423
name: hexon binding
namespace: molecular_function
def: "Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031424
name: keratinization
namespace: biological_process
def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0031425
name: chloroplast RNA processing
namespace: biological_process
def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah]
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0031426
name: polycistronic mRNA processing
namespace: biological_process
def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah]
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0031427
name: response to methotrexate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:ef, GOC:mah, ISBN:0198506732]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0031428
name: box C/D methylation guide snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing a box C/D type RNA that is capable of ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya." [ISBN:0879695897, PMID:11842104, PMID:17284456]
synonym: "box C/D small nucleolar ribonucleoprotein complex" NARROW [GOC:cjm]
synonym: "box C/D snoRNP complex" NARROW [ISBN:0879695897]
synonym: "box C/D snoRNP ribose 2'-O methylase complex" EXACT [PMID:17284456]
synonym: "box C/D snoRNP ribose-2'-O-methyltransferase complex" NARROW [PMID:17284456]
synonym: "box C/D sRNP complex" NARROW [PMID:11842104]
is_a: GO:0170049 ! box C/D RNP complex

[Term]
id: GO:0031429
name: box H/ACA snoRNP complex
namespace: cellular_component
def: "A box H/ACA small nucleolar ribonucleoprotein complex located in the nucleolus that catalyzes pseudouridylation of ribosomal RNA residues. The complex is composed of four different core proteins that assemble onto a H/ACA guide RNA scaffold that identifies specific uridines in rRNA for modification during ribosome synthesis." [GOC:vw, PMID:17284456, PMID:20227365, PMID:22065625]
synonym: "box H/ACA small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm]
synonym: "box H/ACA snoRNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:17284456]
is_a: GO:0072588 ! box H/ACA RNP complex
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0031430
name: M band
namespace: cellular_component
def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
synonym: "M disc" EXACT []
synonym: "M line" NARROW []
synonym: "mesophragma" EXACT []
synonym: "midline" BROAD []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0031431
name: Dbf4-dependent protein kinase complex
namespace: cellular_component
def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100]
synonym: "Cdc7-Dbf4 complex" NARROW []
synonym: "DDK" EXACT []
synonym: "Hsk1-Dfp1 kinase complex" NARROW []
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0031432
name: titin binding
namespace: molecular_function
def: "Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031433
name: telethonin binding
namespace: molecular_function
def: "Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031434
name: mitogen-activated protein kinase kinase binding
namespace: molecular_function
def: "Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase." [GOC:mah]
synonym: "MAPKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0031435
name: mitogen-activated protein kinase kinase kinase binding
namespace: molecular_function
def: "Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase." [GOC:bf]
synonym: "MAPKKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0031436
name: BRCA1-BARD1 complex
namespace: cellular_component
def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0031437
name: obsolete regulation of mRNA cleavage
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function
is_obsolete: true

[Term]
id: GO:0031438
name: obsolete negative regulation of mRNA cleavage
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function
synonym: "down regulation of mRNA cleavage" EXACT []
synonym: "down-regulation of mRNA cleavage" EXACT []
synonym: "downregulation of mRNA cleavage" EXACT []
synonym: "inhibition of mRNA cleavage" NARROW []
is_obsolete: true

[Term]
id: GO:0031439
name: obsolete positive regulation of mRNA cleavage
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function
synonym: "activation of mRNA cleavage" NARROW []
synonym: "stimulation of mRNA cleavage" NARROW []
synonym: "up regulation of mRNA cleavage" EXACT []
synonym: "up-regulation of mRNA cleavage" EXACT []
synonym: "upregulation of mRNA cleavage" EXACT []
is_obsolete: true

[Term]
id: GO:0031440
name: regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]
is_a: GO:0050684 ! regulation of mRNA processing
relationship: regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031441
name: negative regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah]
synonym: "down regulation of mRNA 3'-end processing" EXACT []
synonym: "down-regulation of mRNA 3'-end processing" EXACT []
synonym: "downregulation of mRNA 3'-end processing" EXACT []
synonym: "inhibition of mRNA 3'-end processing" NARROW []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:0050686 ! negative regulation of mRNA processing
relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031442
name: positive regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah]
synonym: "activation of mRNA 3'-end processing" NARROW []
synonym: "stimulation of mRNA 3'-end processing" NARROW []
synonym: "up regulation of mRNA 3'-end processing" EXACT []
synonym: "up-regulation of mRNA 3'-end processing" EXACT []
synonym: "upregulation of mRNA 3'-end processing" EXACT []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:0050685 ! positive regulation of mRNA processing
relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031443
name: fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle]
synonym: "fast-twitch skeletal fiber contraction" EXACT []
synonym: "fast-twitch skeletal fibre contraction" EXACT []
synonym: "fast-twitch skeletal muscle fibre contraction" EXACT []
synonym: "fast-twitch skeletal myofiber contraction" EXACT []
synonym: "fast-twitch skeletal myofibre contraction" EXACT []
is_a: GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0031444
name: slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle]
synonym: "slow-twitch skeletal muscle fibre contraction" EXACT []
is_a: GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0031445
name: regulation of heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah]
synonym: "regulation of heterochromatin assembly" EXACT []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1902275 ! regulation of chromatin organization
relationship: regulates GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031446
name: regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction
relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031447
name: negative regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW []
synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031448
name: positive regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "activation of fast-twitch skeletal muscle contraction" NARROW []
synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW []
synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT []
is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031449
name: regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction
relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031450
name: negative regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW []
synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031451
name: positive regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "activation of slow-twitch skeletal muscle contraction" NARROW []
synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW []
synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT []
is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031452
name: negative regulation of heterochromatin formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [PMID:16855380]
synonym: "chromatin decompaction" EXACT []
synonym: "chromatin decondensation" EXACT [PMID:16855380]
synonym: "down regulation of heterochromatin formation" EXACT []
synonym: "down-regulation of heterochromatin formation" EXACT []
synonym: "downregulation of heterochromatin formation" EXACT []
synonym: "inhibition of heterochromatin formation" NARROW []
synonym: "negative regulation of heterochromatin assembly" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0031445 ! regulation of heterochromatin formation
is_a: GO:1905268 ! negative regulation of chromatin organization
relationship: negatively_regulates GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031453
name: positive regulation of heterochromatin formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah]
synonym: "activation of heterochromatin formation" NARROW []
synonym: "positive regulation of heterochromatin assembly" EXACT []
synonym: "stimulation of heterochromatin formation" NARROW []
synonym: "up regulation of heterochromatin formation" EXACT []
synonym: "up-regulation of heterochromatin formation" EXACT []
synonym: "upregulation of heterochromatin formation" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin formation
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1905269 ! positive regulation of chromatin organization
relationship: positively_regulates GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031455
name: glycine betaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah]
synonym: "glycine betaine metabolism" EXACT []
synonym: "N-trimethylglycine metabolic process" EXACT []
synonym: "N-trimethylglycine metabolism" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process

[Term]
id: GO:0031456
name: glycine betaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah]
synonym: "glycine betaine anabolism" EXACT []
synonym: "glycine betaine biosynthesis" EXACT []
synonym: "glycine betaine formation" EXACT []
synonym: "glycine betaine synthesis" EXACT []
synonym: "N-trimethylglycine biosynthesis" EXACT []
synonym: "N-trimethylglycine biosynthetic process" EXACT []
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0031455 ! glycine betaine metabolic process

[Term]
id: GO:0031457
name: glycine betaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah]
synonym: "glycine betaine breakdown" EXACT []
synonym: "glycine betaine catabolism" EXACT []
synonym: "glycine betaine degradation" EXACT []
synonym: "N-trimethylglycine catabolic process" EXACT []
synonym: "N-trimethylglycine catabolism" EXACT []
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0031455 ! glycine betaine metabolic process

[Term]
id: GO:0031458
name: ABC-type betaine transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg]
synonym: "ABC-type betaine transmembrane transporter activity" EXACT []
synonym: "ATP-dependent betaine transporter activity" EXACT []
synonym: "ATPase-coupled betaine transporter activity" RELATED []
synonym: "betaine ABC transporter" NARROW []
synonym: "betaine-transporting ATPase activity" EXACT []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0031459
name: ABC-type glycine betaine transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg, RHEA:32783]
synonym: "ATP-dependent glycine betaine transporter activity" EXACT []
synonym: "ATPase-coupled glycine betaine transporter activity" RELATED []
synonym: "glycine betaine ABC transporter" NARROW []
synonym: "glycine betaine-transporting ATPase activity" RELATED []
synonym: "N-trimethylglycine-transporting ATPase activity" EXACT []
xref: MetaCyc:TRANS-RXN-283
xref: RHEA:32783
is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity
is_a: GO:0015418 ! ABC-type quaternary ammonium compound transporting activity

[Term]
id: GO:0031460
name: glycine betaine transport
namespace: biological_process
def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "N-trimethylglycine transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015838 ! amino-acid betaine transport

[Term]
id: GO:0031461
name: cullin-RING ubiquitin ligase complex
namespace: cellular_component
def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]
synonym: "CRL complex" EXACT []
synonym: "cullin complex" EXACT []
synonym: "cullin-RING ligase" RELATED []
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:0031462
name: Cul2-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
synonym: "CBC complex" BROAD []
synonym: "CDL2 complex" EXACT []
synonym: "CRL2 complex" EXACT []
synonym: "cullin-RING ligase 2" EXACT []
synonym: "EC2S complex" BROAD []
synonym: "ECS complex" BROAD []
synonym: "SCF2 complex" RELATED []
synonym: "VBC complex" NARROW []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031463
name: Cul3-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]
synonym: "BC3B complex" EXACT []
synonym: "BCR3 complex" EXACT []
synonym: "CDL3 complex" EXACT []
synonym: "CRL3 complex" EXACT []
synonym: "cullin-RING ligase 3" EXACT []
synonym: "SCF3 complex" RELATED []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031464
name: Cul4A-RING E3 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]
synonym: "CDL4 complex" EXACT []
synonym: "CRL4 complex" EXACT []
synonym: "cullin-RING ligase 4A" EXACT []
synonym: "DCX complex" EXACT []
synonym: "SCF4 complex" RELATED []
synonym: "VDC complex" NARROW []
is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex

[Term]
id: GO:0031465
name: Cul4B-RING E3 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063]
synonym: "cullin-RING ligase 4B" EXACT []
is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex

[Term]
id: GO:0031466
name: Cul5-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
synonym: "CDL5 complex" EXACT []
synonym: "CRL5 complex" EXACT []
synonym: "cullin-RING ligase 5" EXACT []
synonym: "EC2S complex" BROAD []
synonym: "SCF5 complex" RELATED []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031467
name: Cul7-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063]
synonym: "CDL7 complex" EXACT []
synonym: "CRL7 complex" EXACT []
synonym: "cullin-RING ligase 7" EXACT []
synonym: "SCF7 complex" EXACT []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031468
name: nuclear membrane reassembly
namespace: biological_process
def: "The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah]
synonym: "nuclear envelope reassembly" RELATED []
is_a: GO:0071709 ! membrane assembly
is_a: GO:0071763 ! nuclear membrane organization

[Term]
id: GO:0031469
name: bacterial microcompartment
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081, PMID:34058518, PMID:34340100]
subset: goslim_pir
synonym: "BAC" BROAD []
synonym: "BMC" BROAD []
synonym: "MCP" BROAD []
synonym: "polyhedral organelle" RELATED []
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0031470
name: carboxysome
namespace: cellular_component
def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO2. It augments the concentration of CO2 in the vicinity of RuBisCO to increase the efficiency of CO2 fixation under atmospheric conditions." [GOC:js, PMID:28934381, PMID:8157606, PMID:8491708]
xref: Wikipedia:Carboxysome
is_a: GO:0031469 ! bacterial microcompartment

[Term]
id: GO:0031471
name: ethanolamine degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753]
synonym: "ethanolamine metabolosome" RELATED []
is_a: GO:0031469 ! bacterial microcompartment

[Term]
id: GO:0031472
name: propanediol degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
is_a: GO:0031469 ! bacterial microcompartment

[Term]
id: GO:0031473
name: myosin III binding
namespace: molecular_function
def: "Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0031474
name: myosin IV complex
namespace: cellular_component
def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [Wikipedia:Myosin]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031475
name: myosin V complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [Wikipedia:Myosin]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031476
name: myosin VI complex
namespace: cellular_component
def: "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [PMID:15473855]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031477
name: myosin VII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [PMID:28660889]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031478
name: myosin VIII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [PMID:25247701]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031479
name: myosin IX complex
namespace: cellular_component
def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [PMID:29679756]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031480
name: myosin X complex
namespace: cellular_component
def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [https://doi.org/10.9729/AM.2018.48.2.33, PMID:27580874]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031481
name: myosin XI complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [PMID:22973289, PMID:29307817]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031482
name: myosin XII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [PMID:10722873]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031483
name: myosin XIII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [PMID:10722873]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031484
name: myosin XIV complex
namespace: cellular_component
def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [PMID:10722873]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031485
name: myosin XV complex
namespace: cellular_component
def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [PMID:10722873]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031486
name: myosin XVI complex
namespace: cellular_component
def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [PMID:11294886, PMID:32451869]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031487
name: myosin XVII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [PMID:24443438]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031488
name: myosin XVIII complex
namespace: cellular_component
def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031489
name: myosin V binding
namespace: molecular_function
def: "Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, PMID:11212351, PMID:33541831]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0031490
name: chromatin DNA binding
namespace: molecular_function
def: "Binding to DNA that is assembled into chromatin." [GOC:mah]
is_a: GO:0003677 ! DNA binding
is_a: GO:0003682 ! chromatin binding

[Term]
id: GO:0031491
name: nucleosome binding
namespace: molecular_function
def: "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]
is_a: GO:0003682 ! chromatin binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0031492
name: nucleosomal DNA binding
namespace: molecular_function
def: "Binding to the DNA portion of a nucleosome." [GOC:mah]
is_a: GO:0031490 ! chromatin DNA binding
is_a: GO:0031491 ! nucleosome binding

[Term]
id: GO:0031493
name: obsolete nucleosomal histone binding
namespace: molecular_function
def: "OBSOLETE. Binding to a histone that is assembled into a nucleosome." [GOC:mah]
comment: This term was obsoleted because it represents both an activity and a cellular component.
is_obsolete: true
consider: GO:0000786
consider: GO:0042393

[Term]
id: GO:0031494
name: regulation of mating type switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031495
name: negative regulation of mating type switching
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching." [GOC:mah]
synonym: "down regulation of mating type switching" EXACT []
synonym: "down-regulation of mating type switching" EXACT []
synonym: "downregulation of mating type switching" EXACT []
synonym: "inhibition of mating type switching" NARROW []
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031496
name: positive regulation of mating type switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah]
synonym: "activation of mating type switching" NARROW []
synonym: "stimulation of mating type switching" NARROW []
synonym: "up regulation of mating type switching" EXACT []
synonym: "up-regulation of mating type switching" EXACT []
synonym: "upregulation of mating type switching" EXACT []
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031498
name: obsolete chromatin disassembly
namespace: biological_process
def: "OBSOLETE. The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130]
comment: This term has been obsoleted because this process doesn't happen independently from assembly and is always tied to chromatin remodeling.
synonym: "chromatin maintenance" BROAD []
is_obsolete: true

[Term]
id: GO:0031499
name: TRAMP complex
namespace: cellular_component
def: "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control." [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137]
synonym: "TRAMP4 complex" NARROW []
synonym: "TRAMP5 complex" NARROW []
synonym: "Trf4 complex" NARROW []
synonym: "Trf4 poly(A) polymerase complex" NARROW []
synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" NARROW []
xref: Wikipedia:TRAMP_complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0031500
name: Tea1 cell-end complex
namespace: cellular_component
def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270]
is_a: GO:0005875 ! microtubule associated complex
relationship: part_of GO:0000133 ! polarisome

[Term]
id: GO:0031501
name: mannosyltransferase complex
namespace: cellular_component
def: "A complex that possesses mannosyltransferase activity." [GOC:mah]
subset: goslim_pir
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0031502
name: dolichyl-phosphate-mannose-protein mannosyltransferase complex
namespace: cellular_component
def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, GOC:pr, PMID:15948957]
comment: Note that GO:0004169 'dolichyl-phosphate-mannose-protein mannosyltransferase activity' (part of protein O-linked mannosylation) has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543.
synonym: "PMT family mannosyltransferase complex" RELATED []
synonym: "protein O-mannosyltransferase complex" EXACT []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031503
name: protein-containing complex localization
namespace: biological_process
alt_id: GO:0034629
def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "cellular protein complex localisation" RELATED [GOC:mah]
synonym: "cellular protein complex localization" RELATED []
synonym: "cellular protein-containing complex localization" RELATED []
synonym: "establishment and maintenance of cellular protein complex localization" RELATED []
synonym: "establishment and maintenance of protein complex localization" EXACT []
synonym: "protein complex localisation" EXACT [GOC:mah]
synonym: "protein complex localization" RELATED []
is_a: GO:0051179 ! localization

[Term]
id: GO:0031504
name: peptidoglycan-based cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]
synonym: "peptidoglycan-based cell wall organisation" EXACT [GOC:mah]
synonym: "peptidoglycan-based cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0031505
name: fungal-type cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]
synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED []
synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW []
synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW []
synonym: "chitin-containing cell wall organization and biogenesis" RELATED []
synonym: "fungal-type cell wall organization and biogenesis" RELATED []
is_a: GO:0071555 ! cell wall organization
is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis

[Term]
id: GO:0031506
name: cell wall glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues." [GOC:mah]
synonym: "cell wall glycoprotein anabolism" EXACT []
synonym: "cell wall glycoprotein biosynthesis" EXACT []
synonym: "cell wall glycoprotein formation" EXACT []
synonym: "cell wall glycoprotein synthesis" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0031507
name: heterochromatin formation
namespace: biological_process
alt_id: GO:0006342
alt_id: GO:0006343
alt_id: GO:0016440
alt_id: GO:0070869
alt_id: GO:1904497
def: "An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [PMID:25192661, PMID:33827924]
synonym: "chromatin silencing" EXACT []
synonym: "chromatin-mediated silencing" EXACT []
synonym: "establishment of chromatin silencing" RELATED []
synonym: "establishment of heterochromatic silencing" RELATED []
synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah]
synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie]
synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie]
synonym: "heterochromatic silencing" RELATED []
synonym: "heterochromatin assembly" EXACT []
synonym: "heterochromatin assembly involved in chromatin silencing" RELATED []
synonym: "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" NARROW []
synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie]
synonym: "heterochromatin formation involved in chromatin silencing" RELATED []
synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie]
synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie]
synonym: "heterochromatin maintenance" BROAD []
synonym: "TGS" BROAD []
synonym: "transcriptional gene silencing" RELATED []
is_a: GO:0045814 ! negative regulation of gene expression, epigenetic

[Term]
id: GO:0031508
name: pericentric heterochromatin formation
namespace: biological_process
alt_id: GO:0030702
alt_id: GO:1990141
def: "The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA." [GOC:mah, PMID:14612388, PMID:20206496, PMID:22729156]
synonym: "centric heterochromatin formation" RELATED []
synonym: "centromere chromatin silencing" EXACT [GOC:mah]
synonym: "centromeric heterochromatin biosynthesis" EXACT []
synonym: "centromeric heterochromatin formation" EXACT []
synonym: "centromeric silencing" EXACT [GOC:vw]
synonym: "chromatin silencing at centromere" EXACT []
synonym: "chromatin silencing at centromere outer repeat region" NARROW []
synonym: "chromatin silencing at pericentric region" RELATED [GOC:mah]
synonym: "heterochromatic silencing at centromere" EXACT []
synonym: "pericentric heterochromatin assembly" EXACT []
is_a: GO:0140719 ! constitutive heterochromatin formation

[Term]
id: GO:0031509
name: subtelomeric heterochromatin formation
namespace: biological_process
alt_id: GO:0006348
alt_id: GO:0035390
alt_id: GO:0099114
def: "The compaction of chromatin into heterochromatin at the subtelomeric region." [GOC:mah, PMID:10219245, PMID:26205977]
synonym: "chromatin silencing at subtelomere" RELATED []
synonym: "chromatin silencing at telomere" EXACT []
synonym: "establishment of chromatin silencing at telomere" RELATED []
synonym: "heterochromatic silencing at subtelomere" RELATED []
synonym: "heterochromatic silencing at telomere" EXACT []
synonym: "regulation of chromatin silencing at telomere" RELATED []
synonym: "regulation of subtelomeric heterochromatin assembly" RELATED []
synonym: "subtelomere chromatin silencing" RELATED [GOC:mah]
synonym: "subtelomeric heterochromatin assembly" EXACT []
synonym: "subtelomeric silencing" EXACT [GOC:mah]
synonym: "telomere chromatin silencing" EXACT [GOC:mah]
synonym: "Telomere Position Effect" EXACT [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:21847107]
synonym: "telomeric heterochromatin assembly" RELATED []
synonym: "telomeric heterochromatin formation" RELATED []
synonym: "telomeric silencing" EXACT [GOC:bf]
is_a: GO:0140719 ! constitutive heterochromatin formation
relationship: part_of GO:0032200 ! telomere organization

[Term]
id: GO:0031510
name: SUMO activating enzyme complex
namespace: cellular_component
def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841]
synonym: "SAE" EXACT []
synonym: "SUMO E1 activator enzyme complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0031511
name: Mis6-Sim4 complex
namespace: cellular_component
def: "A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182]
synonym: "Mcm21" RELATED []
synonym: "Mis6 centromere subcomplex" NARROW []
synonym: "Mis6-Mal2-Sim4 centromere complex" EXACT [GOC:vw, PMID:21445296]
synonym: "Sim4 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000939 ! inner kinetochore

[Term]
id: GO:0031514
name: motile cilium
namespace: cellular_component
alt_id: GO:0009434
alt_id: GO:0031512
def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]
synonym: "microtubule-based flagellum" RELATED []
synonym: "motile cilia" EXACT []
synonym: "motile primary cilia" RELATED []
synonym: "motile primary cilium" RELATED []
synonym: "motile secondary cilium" RELATED []
synonym: "nodal cilium" RELATED []
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031515
name: tRNA (m1A) methyltransferase complex
namespace: cellular_component
def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]
is_a: GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0031516
name: far-red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln]
is_a: GO:0009883 ! red or far-red light photoreceptor activity

[Term]
id: GO:0031517
name: red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln]
is_a: GO:0009883 ! red or far-red light photoreceptor activity

[Term]
id: GO:0031518
name: CBF3 complex
namespace: cellular_component
def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0031519
name: PcG protein complex
namespace: cellular_component
def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]
subset: goslim_pir
synonym: "Polycomb Group protein complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0031520
name: plasma membrane of cell tip
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah]
synonym: "'plasma membrane, cell tip'" EXACT []
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0031521
name: spitzenkorper
namespace: cellular_component
def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0001411 ! hyphal tip
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0031522
name: cell envelope Sec protein transport complex
namespace: cellular_component
def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057]
comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'.
synonym: "plasma membrane Sec complex" RELATED []
synonym: "Sec complex" BROAD []
synonym: "Sec secretion complex" NARROW []
synonym: "Sec translocation complex" NARROW []
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0031523
name: Myb complex
namespace: cellular_component
def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
synonym: "Myeloblastosis proto-oncogene protein complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0031524
name: menthol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah]
synonym: "menthol metabolism" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0031525
name: menthol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah]
synonym: "menthol anabolism" EXACT []
synonym: "menthol biosynthesis" EXACT []
synonym: "menthol formation" EXACT []
synonym: "menthol synthesis" EXACT []
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0031524 ! menthol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0031526
name: brush border membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005903 ! brush border

[Term]
id: GO:0031527
name: filopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0031528
name: microvillus membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005902 ! microvillus

[Term]
id: GO:0031529
name: ruffle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235]
synonym: "ruffle organisation" EXACT [GOC:mah]
synonym: "ruffle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0031530
name: gonadotropin-releasing hormone receptor binding
namespace: molecular_function
def: "Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [GOC:pr, PMID:15196882]
synonym: "GnRH receptor binding" EXACT []
synonym: "gonadotrophin-releasing hormone receptor binding" EXACT [GOC:dph]
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0031531
name: thyrotropin-releasing hormone receptor binding
namespace: molecular_function
alt_id: GO:0031888
def: "Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728]
synonym: "thyrotropin releasing hormone receptor binding" EXACT []
synonym: "thyrotropin-releasing hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0031532
name: obsolete actin cytoskeleton reorganization
namespace: biological_process
alt_id: GO:0007012
def: "OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
comment: This term was obsoleted because it represents the same process as actin cytoskeleton organization ; GO:0030036
synonym: "actin cytoskeleton remodeling" EXACT []
synonym: "actin cytoskeleton reorganisation" EXACT []
is_obsolete: true
replaced_by: GO:0030036

[Term]
id: GO:0031533
name: mRNA capping enzyme complex
namespace: cellular_component
def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220, PMID:12455993, PMID:9345280]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0031534
name: minus-end directed microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw]
is_a: GO:0051012 ! microtubule sliding

[Term]
id: GO:0031535
name: plus-end directed microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw]
is_a: GO:0051012 ! microtubule sliding

[Term]
id: GO:0031536
name: positive regulation of exit from mitosis
namespace: biological_process
def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah]
synonym: "activation of exit from mitosis" NARROW []
synonym: "stimulation of exit from mitosis" NARROW []
synonym: "up regulation of exit from mitosis" EXACT []
synonym: "up-regulation of exit from mitosis" EXACT []
synonym: "upregulation of exit from mitosis" EXACT []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
relationship: positively_regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0031537
name: regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "regulation of anthocyanin metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0031538
name: negative regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "down regulation of anthocyanin metabolic process" EXACT []
synonym: "down-regulation of anthocyanin metabolic process" EXACT []
synonym: "downregulation of anthocyanin metabolic process" EXACT []
synonym: "inhibition of anthocyanin metabolic process" NARROW []
synonym: "negative regulation of anthocyanin metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
relationship: negatively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0031539
name: positive regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "activation of anthocyanin metabolic process" NARROW []
synonym: "positive regulation of anthocyanin metabolism" EXACT []
synonym: "stimulation of anthocyanin metabolic process" NARROW []
synonym: "up regulation of anthocyanin metabolic process" EXACT []
synonym: "up-regulation of anthocyanin metabolic process" EXACT []
synonym: "upregulation of anthocyanin metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
relationship: positively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0031540
name: regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "regulation of anthocyanin anabolism" EXACT []
synonym: "regulation of anthocyanin biosynthesis" EXACT []
synonym: "regulation of anthocyanin formation" EXACT []
synonym: "regulation of anthocyanin synthesis" EXACT []
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
relationship: regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process

[Term]
id: GO:0031541
name: negative regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "down regulation of anthocyanin biosynthetic process" EXACT []
synonym: "down-regulation of anthocyanin biosynthetic process" EXACT []
synonym: "downregulation of anthocyanin biosynthetic process" EXACT []
synonym: "inhibition of anthocyanin biosynthetic process" NARROW []
synonym: "negative regulation of anthocyanin anabolism" EXACT []
synonym: "negative regulation of anthocyanin biosynthesis" EXACT []
synonym: "negative regulation of anthocyanin formation" EXACT []
synonym: "negative regulation of anthocyanin synthesis" EXACT []
is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process
is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process
is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process
relationship: negatively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process

[Term]
id: GO:0031542
name: positive regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "activation of anthocyanin biosynthetic process" NARROW []
synonym: "positive regulation of anthocyanin anabolism" EXACT []
synonym: "positive regulation of anthocyanin biosynthesis" EXACT []
synonym: "positive regulation of anthocyanin formation" EXACT []
synonym: "positive regulation of anthocyanin synthesis" EXACT []
synonym: "stimulation of anthocyanin biosynthetic process" NARROW []
synonym: "up regulation of anthocyanin biosynthetic process" EXACT []
synonym: "up-regulation of anthocyanin biosynthetic process" EXACT []
synonym: "upregulation of anthocyanin biosynthetic process" EXACT []
is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process
is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process
is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process
relationship: positively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process

[Term]
id: GO:0031543
name: peptidyl-proline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]
synonym: "proline hydroxylase activity" BROAD [GOC:krc, GOC:pr]
synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [GOC:krc, GOC:pr]
synonym: "prolyl 4-hydroxylase activity" BROAD [GOC:krc, GOC:pr]
synonym: "prolyl hydroxylase activity" BROAD [GOC:krc, GOC:pr]
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0031544
name: peptidyl-proline 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah]
xref: Reactome:R-HSA-9630769 "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23"
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0031545
name: peptidyl-proline 4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah]
synonym: "HIF-type prolyl 4-hydroxylase" NARROW []
synonym: "prolyl 4-hydroxylase" BROAD []
xref: Reactome:R-HSA-1234165 "Nuclear PHD1,3 hydroxylates proline residues on HIF3A"
xref: Reactome:R-HSA-1234166 "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A)"
xref: Reactome:R-HSA-1234173 "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A"
xref: Reactome:R-HSA-1234177 "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A"
xref: Reactome:R-HSA-1234179 "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)"
xref: Reactome:R-HSA-1234181 "Nuclear PHD1,3 hydroxylates proline residues on HIF1A"
xref: RHEA:63484
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0031546
name: brain-derived neurotrophic factor receptor binding
namespace: molecular_function
def: "Binding to a brain-derived neurotrophic factor receptor." [GOC:mah]
synonym: "BDNF receptor binding" EXACT []
synonym: "brain-derived neurotrophic factor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0031547
name: brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "BDNF receptor signaling pathway" EXACT []
synonym: "BDNF signalling pathway" EXACT []
synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0031548
name: regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "regulation of BDNF receptor signaling pathway" EXACT []
synonym: "regulation of BDNF receptor signalling pathway" EXACT []
synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031549
name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "negative regulation of BDNF receptor signaling pathway" EXACT []
synonym: "negative regulation of BDNF receptor signalling pathway" EXACT []
synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031550
name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "positive regulation of BDNF receptor signaling pathway" EXACT []
synonym: "positive regulation of BDNF receptor signalling pathway" EXACT []
synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031551
name: regulation of brain-derived neurotrophic factor-activated receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of BDNF receptor activity" EXACT []
synonym: "regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity

[Term]
id: GO:0031552
name: obsolete negative regulation of brain-derived neurotrophic factor-activated receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "negative regulation of BDNF receptor activity" EXACT []
synonym: "negative regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_obsolete: true

[Term]
id: GO:0031553
name: obsolete positive regulation of brain-derived neurotrophic factor-activated receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "positive regulation of BDNF receptor activity" EXACT []
synonym: "positive regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0031554
name: regulation of termination of DNA-templated transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:mlg, GOC:txnOH]
synonym: "regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "regulation of DNA-templated transcription, termination" EXACT []
synonym: "regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2]
synonym: "transcription antiterminator activity" RELATED []
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:2001141 ! regulation of RNA biosynthetic process
relationship: regulates GO:0006353 ! DNA-templated transcription termination

[Term]
id: GO:0031555
name: transcriptional attenuation
namespace: biological_process
def: "A negative regulation of gene expression mechanism by which bacteria and archae can direct RNA polymerase to prematurely terminate transcription in response to a specific metabolic signal." [PMID:12210530, PMID:15851059, PMID:7007895]
xref: Wikipedia:Attenuator_(genetics)
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0060566 ! positive regulation of termination of DNA-templated transcription

[Term]
id: GO:0031556
name: transcriptional attenuation by ribosome
namespace: biological_process
def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682]
synonym: "ribosome-mediated transcriptional attenuation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031555 ! transcriptional attenuation

[Term]
id: GO:0031557
name: obsolete induction of programmed cell death in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0012501 programmed cell death.
synonym: "induction of programmed cell death in response to chemical stimulus" EXACT []
synonym: "induction of programmed cell death in response to chemical substance" EXACT []
is_obsolete: true

[Term]
id: GO:0031558
name: obsolete induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0006915 apoptotic process.
synonym: "induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "induction of apoptosis in response to chemical substance" EXACT []
is_obsolete: true

[Term]
id: GO:0031559
name: oxidosqualene cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene." [GOC:ct]
comment: Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'.
synonym: "2,3-oxidosqualene cyclase activity" EXACT [GOC:mah]
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0031560
name: cellular bud neck polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0031561
name: cellular bud tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0005934 ! cellular bud tip

[Term]
id: GO:0031562
name: hyphal tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0001411 ! hyphal tip

[Term]
id: GO:0031563
name: mating projection tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0043332 ! mating projection tip

[Term]
id: GO:0031564
name: transcription antitermination
namespace: biological_process
def: "A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions." [ISBN:0198577788, PMID:12456320, PMID:21478900, PMID:30191803]
synonym: "transcriptional readthrough" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0060567 ! negative regulation of termination of DNA-templated transcription

[Term]
id: GO:0031565
name: obsolete cytokinesis checkpoint
namespace: biological_process
alt_id: GO:0000135
def: "OBSOLETE. A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates G2/M transition." [GOC:mtg_cell_cycle]
comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning.
synonym: "contractile ring checkpoint" EXACT []
synonym: "septin checkpoint" EXACT []
is_obsolete: true
consider: GO:0044878
consider: GO:0044879

[Term]
id: GO:0031566
name: actomyosin contractile ring maturation
namespace: biological_process
def: "The cellular process in which the contractile ring cytokinetic ring attains its fully functional state." [GOC:vw, PMID:25451933]
synonym: "actomyosin contractile ring maintenance" RELATED []
synonym: "cytokinesis, contractile ring maintenance" RELATED []
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0044837 ! actomyosin contractile ring organization

[Term]
id: GO:0031567
name: mitotic cell size control checkpoint signaling
namespace: biological_process
alt_id: GO:0072471
def: "A signal transduction process that contributes to a cell size control checkpoint during mitosis." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle cell size control checkpoint" RELATED [GOC:mah]
synonym: "mitotic cell size control checkpoint" RELATED []
synonym: "signal transduction involved in cell size control checkpoint" RELATED []
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition

[Term]
id: GO:0031568
name: mitotic G1 cell size control checkpoint signaling
namespace: biological_process
alt_id: GO:0072450
def: "A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of the cell cycle." [GOC:mtg_cell_cycle]
synonym: "G1 cell size control checkpoint" RELATED []
synonym: "G1 cell size control checkpoint signalling" RELATED []
synonym: "mitotic cell cycle G1/S transition size control checkpoint" EXACT []
synonym: "mitotic G1 cell size control checkpoint" EXACT []
synonym: "signal transduction involved in G1 cell size control checkpoint" RELATED []
synonym: "signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED []
is_a: GO:0031567 ! mitotic cell size control checkpoint signaling
is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle

[Term]
id: GO:0031569
name: mitotic G2 cell size control checkpoint signaling
namespace: biological_process
alt_id: GO:0072453
def: "A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis." [GOC:mtg_cell_cycle]
synonym: "G2 cell size control checkpoint" EXACT []
synonym: "G2/M transition size control checkpoint" EXACT []
synonym: "mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah]
synonym: "mitotic G2 cell size control checkpoint" RELATED []
synonym: "signal transduction involved in G2 cell size control checkpoint" RELATED []
synonym: "signal transduction involved in G2/M transition size control checkpoint" RELATED []
synonym: "signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint" RELATED [GOC:mah]
is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle
is_a: GO:0031567 ! mitotic cell size control checkpoint signaling

[Term]
id: GO:0031570
name: DNA integrity checkpoint signaling
namespace: biological_process
alt_id: GO:0072401
def: "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle]
synonym: "DNA integrity checkpoint" EXACT []
synonym: "signal transduction involved in DNA integrity checkpoint" EXACT []
is_a: GO:0000075 ! cell cycle checkpoint signaling

[Term]
id: GO:0031571
name: mitotic G1 DNA damage checkpoint signaling
namespace: biological_process
alt_id: GO:0044783
alt_id: GO:0072431
alt_id: GO:1902400
def: "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "G1 DNA damage checkpoint" RELATED []
synonym: "G1/S DNA damage checkpoint" RELATED []
synonym: "intracellular signal transduction involved in G1 DNA damage checkpoint" EXACT []
synonym: "intracellular signal transduction involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT []
synonym: "mitotic G1 DNA damage checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint" RELATED []
synonym: "signal transduction involved in mitotic G1 DNA damage checkpoint" RELATED []
synonym: "signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0044773 ! mitotic DNA damage checkpoint signaling
is_a: GO:0044819 ! mitotic G1/S transition checkpoint signaling

[Term]
id: GO:0031573
name: mitotic intra-S DNA damage checkpoint signaling
namespace: biological_process
alt_id: GO:0072428
def: "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]
synonym: "intra-S DNA damage checkpoint" EXACT []
synonym: "mitotic intra-S DNA damage checkpoint" EXACT []
synonym: "S-phase checkpoint" BROAD []
synonym: "signal transduction involved in intra-S DNA damage checkpoint" EXACT []
is_a: GO:0044773 ! mitotic DNA damage checkpoint signaling

[Term]
id: GO:0031577
name: spindle checkpoint signaling
namespace: biological_process
alt_id: GO:0072416
def: "A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term.
subset: gocheck_do_not_annotate
synonym: "signal transduction involved in spindle checkpoint" EXACT []
synonym: "spindle checkpoint" EXACT []
xref: Wikipedia:Spindle_checkpoint
is_a: GO:0000075 ! cell cycle checkpoint signaling

[Term]
id: GO:0031578
name: mitotic spindle orientation checkpoint signaling
namespace: biological_process
alt_id: GO:0072483
def: "A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected." [GOC:mtg_cell_cycle, PMID:14616062]
synonym: "mitotic cell cycle spindle orientation checkpoint" EXACT []
synonym: "mitotic spindle orientation checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cell cycle spindle orientation checkpoint" EXACT []
synonym: "SOC" EXACT []
synonym: "spindle position checkpoint" EXACT []
synonym: "SPOC" EXACT []
is_a: GO:0001100 ! negative regulation of exit from mitosis
is_a: GO:0071174 ! mitotic spindle checkpoint signaling

[Term]
id: GO:0031579
name: membrane raft organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah]
synonym: "lipid raft organization" EXACT [GOC:mah]
synonym: "membrane raft organisation" EXACT [GOC:mah]
synonym: "membrane raft organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0031580
name: membrane raft distribution
namespace: biological_process
def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah]
synonym: "lipid raft distribution" EXACT []
is_a: GO:0031579 ! membrane raft organization
is_a: GO:0051665 ! membrane raft localization

[Term]
id: GO:0031581
name: hemidesmosome assembly
namespace: biological_process
def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403]
is_a: GO:0007044 ! cell-substrate junction assembly

[Term]
id: GO:0031582
name: replication fork arrest at rDNA repeats
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw]
synonym: "replication fork arrest at ribosomal DNA repeats" EXACT []
synonym: "replication fork blocking at rDNA repeats" EXACT []
is_a: GO:0043007 ! maintenance of rDNA
is_a: GO:0043111 ! replication fork arrest

[Term]
id: GO:0031583
name: phospholipase D-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase D (PLD) and a subsequent increase in the intracellular concentration of phosphatidic acid (PA)." [GOC:mah, GOC:signaling, PMID:11812783, PMID:15924269]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation.
synonym: "activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling]
synonym: "G-protein signalling, phospholipase D activating pathway" EXACT []
synonym: "phospholipase D-activating G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0031584
name: activation of phospholipase D activity
namespace: biological_process
def: "Any process that initiates the activity of inactive phospholipase D." [GOC:dph, GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010518 ! positive regulation of phospholipase activity

[Term]
id: GO:0031585
name: regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling]
subset: gocheck_obsoletion_candidate
synonym: "regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling]
synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph]
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:0031586
name: obsolete negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of IP3 receptor activity" EXACT []
synonym: "down-regulation of IP3 receptor activity" EXACT []
synonym: "downregulation of IP3 receptor activity" EXACT []
synonym: "inhibition of IP3 receptor activity" NARROW []
synonym: "negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling]
synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0031587
name: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling]
subset: gocheck_obsoletion_candidate
synonym: "activation of IP3 receptor activity" NARROW []
synonym: "positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf]
synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph]
synonym: "stimulation of IP3 receptor activity" NARROW []
synonym: "up regulation of IP3 receptor activity" EXACT []
synonym: "up-regulation of IP3 receptor activity" EXACT []
synonym: "upregulation of IP3 receptor activity" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:0031588
name: nucleotide-activated protein kinase complex
namespace: cellular_component
def: "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw]
synonym: "5'-AMP-activated protein kinase complex" NARROW []
synonym: "ADP-activated protein kinase complex" NARROW []
synonym: "AMP-activated protein kinase complex" NARROW []
synonym: "AMPK complex" RELATED []
synonym: "Snf1 kinase complex" NARROW []
synonym: "Snf1 serine/threonine protein kinase complex" NARROW []
synonym: "SNF1/AMPK protein kinase complex" NARROW []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:0031589
name: cell-substrate adhesion
namespace: biological_process
def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0031590
name: wybutosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037]
synonym: "wybutosine metabolism" EXACT []
synonym: "yW metabolic process" EXACT []
synonym: "yW metabolism" EXACT []
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0031591
name: wybutosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]
comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
synonym: "yW biosynthesis" EXACT []
synonym: "yW biosynthetic process" EXACT []
is_a: GO:0006400 ! tRNA modification
is_a: GO:0031590 ! wybutosine metabolic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0031592
name: centrosomal corona
namespace: cellular_component
def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah]
comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0031593
name: polyubiquitin modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]
is_a: GO:0140030 ! modification-dependent protein binding

[Term]
id: GO:0031594
name: neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512]
synonym: "NMJ" RELATED [GOC:ha]
xref: NIF_Subcellular:sao1124888485
xref: Wikipedia:Neuromuscular_junction
is_a: GO:0045202 ! synapse

[Term]
id: GO:0031595
name: nuclear proteasome complex
namespace: cellular_component
def: "A proteasome found in the nucleus of a cell." [GOC:mah]
is_a: GO:0000502 ! proteasome complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0031596
name: obsolete ER proteasome complex
namespace: cellular_component
def: "OBSOLETE. A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031597
name: cytosolic proteasome complex
namespace: cellular_component
def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0000502 ! proteasome complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0031598
name: nuclear proteasome regulatory particle
namespace: cellular_component
def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005838 ! proteasome regulatory particle
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031599
name: obsolete ER proteasome regulatory particle
namespace: cellular_component
def: "OBSOLETE. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031600
name: cytosolic proteasome regulatory particle
namespace: cellular_component
def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0005838 ! proteasome regulatory particle
relationship: part_of GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0031601
name: nuclear proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005839 ! proteasome core complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031602
name: obsolete ER proteasome core complex
namespace: cellular_component
def: "OBSOLETE. The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031603
name: cytosolic proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0005839 ! proteasome core complex
relationship: part_of GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0031604
name: nuclear proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031605
name: obsolete ER proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "OBSOLETE. The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031606
name: cytosolic proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex
relationship: part_of GO:0031603 ! cytosolic proteasome core complex

[Term]
id: GO:0031607
name: nuclear proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031608
name: obsolete ER proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "OBSOLETE. The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031609
name: cytosolic proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex
relationship: part_of GO:0031603 ! cytosolic proteasome core complex

[Term]
id: GO:0031610
name: nuclear proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031611
name: obsolete ER proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "OBSOLETE. The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031612
name: cytosolic proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle

[Term]
id: GO:0031613
name: nuclear proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031614
name: obsolete ER proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "OBSOLETE. The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031615
name: cytosolic proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle

[Term]
id: GO:0031616
name: spindle pole centrosome
namespace: cellular_component
def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]
is_a: GO:0005813 ! centrosome
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0031619
name: homologous chromosome orientation in meiotic metaphase I
namespace: biological_process
def: "The cell cycle process in which the sister centromeres and kinetochores of one chromosome are fused and orientated so the chromosomes attach to microtubules that emanate from the same spindle pole. This process ensures that homologous l chromosomes are segregated at anaphase of meiosis I." [PMID:15062096]
synonym: "homologous chromosome orientation during meiosis" RELATED [GOC:dph, GOC:tb]
synonym: "homologous chromosome orientation during meiosis I" RELATED []
is_a: GO:0050000 ! chromosome localization
relationship: part_of GO:0043060 ! meiotic metaphase I homologous chromosome alignment

[Term]
id: GO:0031620
name: regulation of fever generation
namespace: biological_process
def: "Any process that modulates the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of pyrexia" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0031650 ! regulation of heat generation
relationship: regulates GO:0001660 ! fever generation

[Term]
id: GO:0031621
name: negative regulation of fever generation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb]
synonym: "down regulation of fever" EXACT []
synonym: "down-regulation of fever" EXACT []
synonym: "downregulation of fever" EXACT []
synonym: "inhibition of fever" NARROW []
synonym: "negative regulation of pyrexia" EXACT []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0031620 ! regulation of fever generation
is_a: GO:0031651 ! negative regulation of heat generation
relationship: negatively_regulates GO:0001660 ! fever generation

[Term]
id: GO:0031622
name: positive regulation of fever generation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of fever generation." [GOC:add]
synonym: "activation of fever" NARROW []
synonym: "positive regulation of pyrexia" EXACT []
synonym: "stimulation of fever" NARROW []
synonym: "up regulation of fever" EXACT []
synonym: "up-regulation of fever" EXACT []
synonym: "upregulation of fever" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0031620 ! regulation of fever generation
is_a: GO:0031652 ! positive regulation of heat generation
relationship: positively_regulates GO:0001660 ! fever generation

[Term]
id: GO:0031623
name: receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]
is_a: GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0031624
name: ubiquitin conjugating enzyme binding
namespace: molecular_function
def: "Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]
is_a: GO:0044390 ! ubiquitin-like protein conjugating enzyme binding

[Term]
id: GO:0031625
name: ubiquitin protein ligase binding
namespace: molecular_function
def: "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]
synonym: "ubiquitin ligase binding" EXACT []
is_a: GO:0044389 ! ubiquitin-like protein ligase binding

[Term]
id: GO:0031626
name: beta-endorphin binding
namespace: molecular_function
def: "Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560]
is_a: GO:0033218 ! amide binding

[Term]
id: GO:0031627
name: telomeric loop formation
namespace: biological_process
def: "The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214]
synonym: "T loop biosynthesis" EXACT []
synonym: "T loop formation" EXACT []
synonym: "t-loop biosynthesis" EXACT []
synonym: "t-loop formation" EXACT []
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0031628
name: opioid receptor binding
namespace: molecular_function
def: "Binding to an opioid receptor." [GOC:nln]
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031629
name: synaptic vesicle fusion to presynaptic active zone membrane
namespace: biological_process
def: "Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]
subset: goslim_synapse
synonym: "synaptic vesicle fusion" BROAD []
synonym: "synaptic vesicle fusion to pre-synaptic membrane" EXACT []
synonym: "synaptic vesicle fusion to presynaptic membrane" EXACT []
is_a: GO:0048499 ! synaptic vesicle membrane organization
is_a: GO:0099500 ! vesicle fusion to plasma membrane
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0031630
name: regulation of synaptic vesicle fusion to presynaptic active zone membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
subset: goslim_synapse
synonym: "regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT []
synonym: "regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization
relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0031631
name: negative regulation of synaptic vesicle fusion to presynaptic active zone membrane
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
synonym: "down regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT []
synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" BROAD []
synonym: "down-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT []
synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" BROAD []
synonym: "downregulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT []
synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" BROAD []
synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" BROAD []
synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane" EXACT []
synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic membrane" BROAD []
synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" BROAD []
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane
is_a: GO:1901633 ! negative regulation of synaptic vesicle membrane organization
is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis
relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0031632
name: positive regulation of synaptic vesicle fusion to presynaptic active zone membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW []
synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "positive regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT []
synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW []
synonym: "up regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT []
synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "up-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT []
synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane
is_a: GO:1901634 ! positive regulation of synaptic vesicle membrane organization
relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0031633
name: xanthophore
namespace: cellular_component
def: "A chromatophore containing yellow pigment." [ISBN:0395825172]
comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells.
is_a: GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0031634
name: replication fork barrier binding
namespace: molecular_function
def: "Binding to replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0031635
name: adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:mah]
synonym: "opioid receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
is_a: GO:0038003 ! G protein-coupled opioid receptor signaling pathway

[Term]
id: GO:0031637
name: regulation of neuronal synaptic plasticity in response to neurotrophin
namespace: biological_process
def: "The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078]
synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT []
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0031638
name: zymogen activation
namespace: biological_process
def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
subset: goslim_chembl
synonym: "zymogen activation by proteolytic cleavage" EXACT []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0031639
name: plasminogen activation
namespace: biological_process
def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733]
subset: goslim_chembl
synonym: "cleavage of plasminogen to plasmin" EXACT []
is_a: GO:0031638 ! zymogen activation

[Term]
id: GO:0031640
name: killing of cells of another organism
namespace: biological_process
alt_id: GO:0001908
def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
synonym: "killing of cells of other organism" EXACT []
is_a: GO:0001906 ! cell killing
is_a: GO:0141061 ! disruption of cell in another organism

[Term]
id: GO:0031641
name: regulation of myelination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051960 ! regulation of nervous system development
relationship: regulates GO:0042552 ! myelination

[Term]
id: GO:0031642
name: negative regulation of myelination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "down regulation of myelination" EXACT []
synonym: "down-regulation of myelination" EXACT []
synonym: "downregulation of myelination" EXACT []
synonym: "inhibition of myelination" NARROW []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0042552 ! myelination

[Term]
id: GO:0031643
name: positive regulation of myelination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "activation of myelination" NARROW []
synonym: "stimulation of myelination" NARROW []
synonym: "up regulation of myelination" EXACT []
synonym: "up-regulation of myelination" EXACT []
synonym: "upregulation of myelination" EXACT []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0042552 ! myelination

[Term]
id: GO:0031644
name: regulation of nervous system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurological system process" EXACT []
synonym: "regulation of neurophysiological process" EXACT []
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0050877 ! nervous system process

[Term]
id: GO:0031645
name: negative regulation of nervous system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of neurological process" EXACT []
synonym: "down-regulation of neurological process" EXACT []
synonym: "downregulation of neurological process" EXACT []
synonym: "inhibition of neurological process" NARROW []
synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of neurological system process" EXACT []
synonym: "negative regulation of neurophysiological process" EXACT []
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0050877 ! nervous system process

[Term]
id: GO:0031646
name: positive regulation of nervous system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of neurological process" NARROW []
synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of neurological system process" EXACT []
synonym: "positive regulation of neurophysiological process" EXACT []
synonym: "stimulation of neurological process" NARROW []
synonym: "up regulation of neurological process" EXACT []
synonym: "up-regulation of neurological process" EXACT []
synonym: "upregulation of neurological process" EXACT []
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0050877 ! nervous system process

[Term]
id: GO:0031647
name: regulation of protein stability
namespace: biological_process
def: "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031648
name: protein destabilization
namespace: biological_process
def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]
synonym: "negative regulation of protein stability" EXACT []
synonym: "protein destabilisation" EXACT [GOC:ah]
is_a: GO:0031647 ! regulation of protein stability

[Term]
id: GO:0031649
name: heat generation
namespace: biological_process
def: "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature." [GOC:mah]
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0031650
name: regulation of heat generation
namespace: biological_process
def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0031649 ! heat generation

[Term]
id: GO:0031651
name: negative regulation of heat generation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of heat generation" EXACT []
synonym: "down-regulation of heat generation" EXACT []
synonym: "downregulation of heat generation" EXACT []
synonym: "inhibition of heat generation" NARROW []
is_a: GO:0031650 ! regulation of heat generation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0031649 ! heat generation

[Term]
id: GO:0031652
name: positive regulation of heat generation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of heat generation" NARROW []
synonym: "stimulation of heat generation" NARROW []
synonym: "up regulation of heat generation" EXACT []
synonym: "up-regulation of heat generation" EXACT []
synonym: "upregulation of heat generation" EXACT []
is_a: GO:0031650 ! regulation of heat generation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0031649 ! heat generation

[Term]
id: GO:0031653
name: heat dissipation
namespace: biological_process
def: "Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah]
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0031654
name: regulation of heat dissipation
namespace: biological_process
def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031655
name: negative regulation of heat dissipation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of heat dissipation" EXACT []
synonym: "down-regulation of heat dissipation" EXACT []
synonym: "downregulation of heat dissipation" EXACT []
synonym: "inhibition of heat dissipation" NARROW []
is_a: GO:0031654 ! regulation of heat dissipation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031656
name: positive regulation of heat dissipation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of heat dissipation" NARROW []
synonym: "stimulation of heat dissipation" NARROW []
synonym: "up regulation of heat dissipation" EXACT []
synonym: "up-regulation of heat dissipation" EXACT []
synonym: "upregulation of heat dissipation" EXACT []
is_a: GO:0031654 ! regulation of heat dissipation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031657
name: obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that controls the frequency, rate or extent of G1 cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:mtg_cell_cycle, GOC:pr]
comment: The term has been obsoleted because it represents a GO-CAM model.
synonym: "G1/S-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD []
is_obsolete: true

[Term]
id: GO:0031658
name: obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
comment: The term has been obsoleted because it represents a GO-CAM model.
synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD []
is_obsolete: true

[Term]
id: GO:0031659
name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
comment: The term has been obsoleted because it represents a GO-CAM model.
synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "positive regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD []
is_obsolete: true

[Term]
id: GO:0031660
name: obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
comment: This term was obsoleted because it is a MF represented as a BP.
synonym: "G2/M-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD []
is_obsolete: true
consider: GO:0010389

[Term]
id: GO:0031661
name: obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
comment: This term was obsoleted because it is a MF represented as a BP.
synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD []
is_obsolete: true
consider: GO:0010389

[Term]
id: GO:0031663
name: lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975]
synonym: "lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "LPS-mediated signaling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide

[Term]
id: GO:0031664
name: regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "regulation of LPS-mediated signaling pathway" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031665
name: negative regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "negative regulation of LPS-mediated signaling pathway" EXACT []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway
is_a: GO:0032102 ! negative regulation of response to external stimulus
relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031666
name: positive regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "positive regulation of LPS-mediated signaling pathway" EXACT []
synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway
is_a: GO:0032103 ! positive regulation of response to external stimulus
relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031667
name: response to nutrient levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0031668
name: obsolete cellular response to extracellular stimulus
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah]
comment: The reason for obsoletion is that this term is too vague.
is_obsolete: true
consider: GO:0051716

[Term]
id: GO:0031669
name: cellular response to nutrient levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0031670
name: cellular response to nutrient
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah]
is_a: GO:0007584 ! response to nutrient
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0031671
name: primary cell septum biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl]
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0140278 ! mitotic division septum assembly

[Term]
id: GO:0031672
name: A band
namespace: cellular_component
def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131]
synonym: "A disc" EXACT []
synonym: "anisotropic disc" EXACT []
synonym: "Q disc" EXACT []
synonym: "transverse disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031673
name: H zone
namespace: cellular_component
def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131]
synonym: "H band" EXACT []
synonym: "H disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0031674
name: I band
namespace: cellular_component
def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131]
synonym: "I disc" EXACT []
synonym: "isotropic disc" EXACT []
synonym: "J disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031676
name: plasma membrane-derived thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu]
synonym: "plasma membrane thylakoid membrane" EXACT []
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0031679
name: obsolete NADH dehydrogenase (plastoquinone) activity
namespace: molecular_function
alt_id: GO:0030024
def: "OBSOLETE. Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah]
comment: The reason for obsoletion is that this term is equivalent to NADPH dehydrogenase (quinone) activity ; GO:0008753.
synonym: "NADH:plastoquinone reductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008753

[Term]
id: GO:0031680
name: G-protein beta/gamma-subunit complex
namespace: cellular_component
def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G-beta/G-gamma complex" EXACT []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031681
name: G-protein beta-subunit binding
namespace: molecular_function
def: "Binding to a G-protein beta subunit." [GOC:mah]
synonym: "G-beta protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031682
name: G-protein gamma-subunit binding
namespace: molecular_function
def: "Binding to a G-protein gamma subunit." [GOC:mah]
synonym: "G-gamma protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031683
name: G-protein beta/gamma-subunit complex binding
namespace: molecular_function
def: "Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0031684
name: obsolete heterotrimeric G-protein complex cycle
namespace: biological_process
def: "OBSOLETE. The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln]
comment: The reason for obsoleting is that it is an arbitrary grouping term that groups the molecular functions required for the G-protein complex cycle, and this is not a bona fide biological process.
is_obsolete: true

[Term]
id: GO:0031685
name: adenosine receptor binding
namespace: molecular_function
def: "Binding to an adenosine receptor." [GOC:mah, GOC:nln]
synonym: "adenosine receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031686
name: A1 adenosine receptor binding
namespace: molecular_function
def: "Binding to an A1 adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A1 adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031687
name: A2A adenosine receptor binding
namespace: molecular_function
def: "Binding to an A2A adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A2A adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031688
name: A2B adenosine receptor binding
namespace: molecular_function
def: "Binding to an A2B adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A2B adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031689
name: A3 adenosine receptor binding
namespace: molecular_function
def: "Binding to an A3 adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A3 adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031690
name: adrenergic receptor binding
namespace: molecular_function
def: "Binding to an adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "adrenergic receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031691
name: alpha-1A adrenergic receptor binding
namespace: molecular_function
def: "Binding to an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1A adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031692
name: alpha-1B adrenergic receptor binding
namespace: molecular_function
def: "Binding to an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1B adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031693
name: alpha-1D adrenergic receptor binding
namespace: molecular_function
def: "Binding to an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1D adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031694
name: alpha-2A adrenergic receptor binding
namespace: molecular_function
def: "Binding to an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2A adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031695
name: alpha-2B adrenergic receptor binding
namespace: molecular_function
def: "Binding to an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2B adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031696
name: alpha-2C adrenergic receptor binding
namespace: molecular_function
def: "Binding to an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2C adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031697
name: beta-1 adrenergic receptor binding
namespace: molecular_function
def: "Binding to a beta-1 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-1 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031698
name: beta-2 adrenergic receptor binding
namespace: molecular_function
def: "Binding to a beta-2 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-2 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031699
name: beta-3 adrenergic receptor binding
namespace: molecular_function
def: "Binding to a beta-3 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-3 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031700
name: adrenomedullin receptor binding
namespace: molecular_function
def: "Binding to an adrenomedullin receptor." [GOC:mah, GOC:nln]
synonym: "adrenomedullin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031701
name: angiotensin receptor binding
namespace: molecular_function
def: "Binding to an angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "angiotensin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031702
name: type 1 angiotensin receptor binding
namespace: molecular_function
def: "Binding to a type 1 angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "AT1 receptor binding" EXACT []
synonym: "type 1 angiotensin receptor ligand" NARROW []
is_a: GO:0031701 ! angiotensin receptor binding

[Term]
id: GO:0031703
name: type 2 angiotensin receptor binding
namespace: molecular_function
def: "Binding to a type 2 angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "AT2 receptor binding" EXACT []
synonym: "type 2 angiotensin receptor ligand" NARROW []
is_a: GO:0031701 ! angiotensin receptor binding

[Term]
id: GO:0031704
name: apelin receptor binding
namespace: molecular_function
alt_id: GO:0042569
def: "Binding to an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050]
synonym: "apelin receptor ligand" NARROW []
synonym: "APJ receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031705
name: bombesin receptor binding
namespace: molecular_function
def: "Binding to a bombesin receptor." [GOC:mah, GOC:nln]
synonym: "bombesin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031706
name: subtype 3 bombesin receptor binding
namespace: molecular_function
def: "Binding to a subtype 3 bombesin receptor." [GOC:mah, GOC:nln]
synonym: "subtype 3 bombesin receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031707
name: endothelin A receptor binding
namespace: molecular_function
def: "Binding to an endothelin A receptor." [GOC:mah, GOC:nln]
synonym: "endothelin A receptor ligand" NARROW []
synonym: "endothelin-1 receptor binding" EXACT []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031708
name: endothelin B receptor binding
namespace: molecular_function
def: "Binding to an endothelin B receptor." [GOC:mah, GOC:nln]
synonym: "endothelin B receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031709
name: gastrin-releasing peptide receptor binding
namespace: molecular_function
def: "Binding to a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln]
synonym: "gastrin-releasing peptide receptor ligand" NARROW []
synonym: "GRP receptor binding" EXACT []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031710
name: neuromedin B receptor binding
namespace: molecular_function
def: "Binding to a neuromedin B receptor." [GOC:mah, GOC:nln]
synonym: "neuromedin B receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031711
name: bradykinin receptor binding
namespace: molecular_function
def: "Binding to a bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "bradykinin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031712
name: B1 bradykinin receptor binding
namespace: molecular_function
def: "Binding to a B1 bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "B1 bradykinin receptor ligand" NARROW []
is_a: GO:0031711 ! bradykinin receptor binding

[Term]
id: GO:0031713
name: B2 bradykinin receptor binding
namespace: molecular_function
def: "Binding to a B2 bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "B2 bradykinin receptor ligand" NARROW []
is_a: GO:0031711 ! bradykinin receptor binding

[Term]
id: GO:0031714
name: C5a anaphylatoxin chemotactic receptor binding
namespace: molecular_function
def: "Binding to a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln]
synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031715
name: C5L2 anaphylatoxin chemotactic receptor binding
namespace: molecular_function
def: "Binding to a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln]
synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW []
is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding

[Term]
id: GO:0031716
name: calcitonin receptor binding
namespace: molecular_function
def: "Binding to a calcitonin receptor." [GOC:mah, GOC:nln]
synonym: "calcitonin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031717
name: cannabinoid receptor binding
namespace: molecular_function
def: "Binding to a cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "cannabinoid receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031718
name: type 1 cannabinoid receptor binding
namespace: molecular_function
def: "Binding to a type 1 cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "type 1 cannabinoid receptor ligand" NARROW []
is_a: GO:0031717 ! cannabinoid receptor binding

[Term]
id: GO:0031719
name: type 2 cannabinoid receptor binding
namespace: molecular_function
def: "Binding to a type 2 cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "type 2 cannabinoid receptor ligand" NARROW []
is_a: GO:0031717 ! cannabinoid receptor binding

[Term]
id: GO:0031720
name: haptoglobin binding
namespace: molecular_function
def: "Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031721
name: hemoglobin alpha binding
namespace: molecular_function
def: "Binding to a hemoglobin alpha chain." [GOC:mah]
is_a: GO:0030492 ! hemoglobin binding

[Term]
id: GO:0031722
name: hemoglobin beta binding
namespace: molecular_function
def: "Binding to a hemoglobin beta chain." [GOC:mah]
is_a: GO:0030492 ! hemoglobin binding

[Term]
id: GO:0031723
name: CXCR4 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CXCR4 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CXCR4 chemokine receptor ligand" NARROW []
synonym: "stromal cell-derived factor 1 receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031724
name: CXCR5 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CXCR5 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CXCR5 chemokine receptor ligand" NARROW []
synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031725
name: CXCR6 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CXCR6 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "bonzo receptor binding" EXACT []
synonym: "CXCR6 chemokine receptor ligand" NARROW []
synonym: "STRL33 receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031726
name: CCR1 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR1 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR1 chemokine receptor ligand" NARROW []
synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031727
name: CCR2 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR2 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR2 chemokine receptor ligand" NARROW []
synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031728
name: CCR3 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR3 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR3 chemokine receptor ligand" NARROW []
synonym: "eosinophil eotaxin receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031729
name: CCR4 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR4 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR4 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031730
name: CCR5 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR5 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR5 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031731
name: CCR6 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR6 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR6 chemokine receptor ligand" NARROW []
synonym: "LARC receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031732
name: CCR7 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR7 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR7 chemokine receptor ligand" NARROW []
synonym: "MIP-3 beta receptor binding" EXACT []
synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031733
name: CCR8 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR8 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR8 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031734
name: CCR9 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR9 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR9 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031735
name: CCR10 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR10 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR10 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031736
name: CCR11 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR11 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR11 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031737
name: CX3C chemokine receptor binding
namespace: molecular_function
def: "Binding to a CX3C chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CX3C chemokine receptor ligand" NARROW []
synonym: "fractalkine receptor binding" EXACT []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0031738
name: XCR1 chemokine receptor binding
namespace: molecular_function
def: "Binding to a XCR1 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "lymphotactin receptor binding" EXACT []
synonym: "XCR1 chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0031739
name: cholecystokinin receptor binding
namespace: molecular_function
def: "Binding to a cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "cholecystokinin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031740
name: type A cholecystokinin receptor binding
namespace: molecular_function
def: "Binding to a type A cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "type A cholecystokinin receptor ligand" NARROW []
is_a: GO:0031739 ! cholecystokinin receptor binding

[Term]
id: GO:0031741
name: type B gastrin/cholecystokinin receptor binding
namespace: molecular_function
def: "Binding to a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW []
is_a: GO:0031739 ! cholecystokinin receptor binding

[Term]
id: GO:0031745
name: cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Binding to a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031746
name: type 1 cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Binding to a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0031745 ! cysteinyl leukotriene receptor binding

[Term]
id: GO:0031747
name: type 2 cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Binding to a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0031745 ! cysteinyl leukotriene receptor binding

[Term]
id: GO:0031748
name: D1 dopamine receptor binding
namespace: molecular_function
def: "Binding to a D1 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D1 dopamine receptor ligand" NARROW []
synonym: "D1A dopamine receptor binding" EXACT []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031749
name: D2 dopamine receptor binding
namespace: molecular_function
def: "Binding to a D2 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D2 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031750
name: D3 dopamine receptor binding
namespace: molecular_function
def: "Binding to a D3 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D3 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031751
name: D4 dopamine receptor binding
namespace: molecular_function
def: "Binding to a D4 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D4 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031752
name: D5 dopamine receptor binding
namespace: molecular_function
def: "Binding to a D5 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D1B dopamine receptor binding" EXACT []
synonym: "D5 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031753
name: endothelial differentiation G protein-coupled receptor binding
namespace: molecular_function
def: "Binding to an endothelial differentiation G protein-coupled receptor." [GOC:mah, GOC:nln]
synonym: "endothelial differentiation G-protein coupled receptor binding" EXACT []
synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031754
name: Edg-1 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Binding to an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding

[Term]
id: GO:0031755
name: Edg-2 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Binding to an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA1 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding

[Term]
id: GO:0031756
name: Edg-3 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Binding to an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding

[Term]
id: GO:0031757
name: Edg-4 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Binding to an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA2 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding

[Term]
id: GO:0031758
name: Edg-5 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Binding to an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding

[Term]
id: GO:0031759
name: Edg-6 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Binding to an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding

[Term]
id: GO:0031760
name: Edg-7 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Binding to an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA3 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding

[Term]
id: GO:0031761
name: fMet-Leu-Phe receptor binding
namespace: molecular_function
def: "Binding to a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln]
synonym: "fMet-Leu-Phe receptor ligand" NARROW []
synonym: "N-formyl peptide receptor binding" EXACT []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031762
name: follicle-stimulating hormone receptor binding
namespace: molecular_function
def: "Binding to a follicle-stimulating hormone receptor." [GOC:mah, GOC:nln]
synonym: "follicle stimulating hormone receptor binding" EXACT []
synonym: "follicle stimulating hormone receptor ligand" NARROW []
synonym: "FSH receptor binding" EXACT []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031763
name: galanin receptor binding
namespace: molecular_function
def: "Binding to a galanin receptor." [GOC:mah, GOC:nln]
synonym: "galanin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031764
name: type 1 galanin receptor binding
namespace: molecular_function
def: "Binding to a type 1 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031765
name: type 2 galanin receptor binding
namespace: molecular_function
def: "Binding to a type 2 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031766
name: type 3 galanin receptor binding
namespace: molecular_function
def: "Binding to a type 3 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031767
name: gastric inhibitory polypeptide receptor binding
namespace: molecular_function
def: "Binding to a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "gastric inhibitory polypeptide receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031768
name: ghrelin receptor binding
namespace: molecular_function
def: "Binding to a ghrelin receptor." [GOC:mah, GOC:nln]
synonym: "ghrelin receptor ligand" NARROW []
synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031769
name: glucagon receptor binding
namespace: molecular_function
def: "Binding to a glucagon receptor." [GOC:mah, GOC:nln]
synonym: "glucagon receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031770
name: growth hormone-releasing hormone receptor binding
namespace: molecular_function
def: "Binding to a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln]
synonym: "growth hormone-releasing hormone receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031771
name: type 1 orexin receptor binding
namespace: molecular_function
def: "Binding to a type 1 orexin receptor." [GOC:mah, GOC:nln]
synonym: "OX1 orexin receptor binding" EXACT []
synonym: "type 1 hypocretin receptor binding" EXACT []
synonym: "type 1 hypocretin receptor ligand" NARROW []
is_a: GO:0042324 ! orexin receptor binding

[Term]
id: GO:0031772
name: type 2 orexin receptor binding
namespace: molecular_function
def: "Binding to a type 2 orexin receptor." [GOC:mah, GOC:nln]
synonym: "OX2 orexin receptor binding" EXACT []
synonym: "type 2 hypocretin receptor binding" EXACT []
synonym: "type 2 hypocretin receptor ligand" NARROW []
is_a: GO:0042324 ! orexin receptor binding

[Term]
id: GO:0031773
name: kisspeptin receptor binding
namespace: molecular_function
def: "Binding to a kisspeptin receptor." [GOC:mah, GOC:nln]
synonym: "G-protein coupled receptor 54 binding" EXACT []
synonym: "hOT7T175 receptor binding" EXACT []
synonym: "hypogonadotropin-1 receptor binding" EXACT []
synonym: "KiSS-1 receptor binding" EXACT []
synonym: "kisspeptin receptor ligand" NARROW []
synonym: "metastin receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031774
name: leukotriene receptor binding
namespace: molecular_function
def: "Binding to a leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "leukotriene receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031775
name: lutropin-choriogonadotropic hormone receptor binding
namespace: molecular_function
def: "Binding to a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln]
synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031776
name: melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Binding to a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031777
name: type 1 melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Binding to a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0031776 ! melanin-concentrating hormone receptor binding

[Term]
id: GO:0031778
name: type 2 melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Binding to a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0031776 ! melanin-concentrating hormone receptor binding

[Term]
id: GO:0031779
name: melanocortin receptor binding
namespace: molecular_function
def: "Binding to a melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "melanocortin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031780
name: corticotropin hormone receptor binding
namespace: molecular_function
alt_id: GO:0071856
def: "Binding to a corticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln]
synonym: "ACTH receptor binding" EXACT []
synonym: "adrenocorticotropic hormone receptor ligand" NARROW []
synonym: "adrenocorticotropin hormone receptor binding" EXACT [GOC:dph, GOC:tb]
synonym: "adrenocorticotropin receptor binding" EXACT [GOC:dph]
synonym: "corticotropin receptor binding" EXACT [GOC:bf]
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031781
name: type 3 melanocortin receptor binding
namespace: molecular_function
def: "Binding to a type 3 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031782
name: type 4 melanocortin receptor binding
namespace: molecular_function
def: "Binding to a type 4 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 4 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031783
name: type 5 melanocortin receptor binding
namespace: molecular_function
def: "Binding to a type 5 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 5 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031784
name: melatonin receptor binding
namespace: molecular_function
def: "Binding to a melatonin receptor." [GOC:mah, GOC:nln]
synonym: "melatonin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031785
name: type 1A melatonin receptor binding
namespace: molecular_function
def: "Binding to a type 1A melatonin receptor." [GOC:mah, GOC:nln]
synonym: "type 1A melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031786
name: type 1B melatonin receptor binding
namespace: molecular_function
def: "Binding to a type 1B melatonin receptor." [GOC:mah, GOC:nln]
synonym: "type 1B melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031787
name: H9 melatonin receptor binding
namespace: molecular_function
def: "Binding to a H9 melatonin receptor." [GOC:mah, GOC:nln]
synonym: "H9 melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031788
name: motilin receptor binding
namespace: molecular_function
def: "Binding to a motilin receptor." [GOC:mah, GOC:nln]
synonym: "motilin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031789
name: G protein-coupled acetylcholine receptor binding
namespace: molecular_function
alt_id: GO:0031790
alt_id: GO:0031791
alt_id: GO:0031792
alt_id: GO:0031793
alt_id: GO:0031794
def: "Binding to a G protein-coupled acetylcholine receptor." [GOC:bf, GOC:mah, GOC:nln]
synonym: "G-protein coupled acetylcholine receptor binding" EXACT []
synonym: "M1 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M2 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M3 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M4 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M5 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "muscarinic acetylcholine receptor binding" EXACT [GOC:bf]
synonym: "muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031795
name: G protein-coupled GABA receptor binding
namespace: molecular_function
def: "Binding to a G protein-coupled (metabotropic) GABA receptor." [GOC:mah, GOC:nln]
synonym: "G-protein coupled GABA receptor binding" EXACT []
synonym: "GABAB receptor binding" EXACT []
synonym: "metabotropic GABA receptor binding" EXACT [GOC:bf]
synonym: "metabotropic GABA receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding
is_a: GO:0050811 ! GABA receptor binding

[Term]
id: GO:0031796
name: type 1 metabotropic GABA receptor binding
namespace: molecular_function
def: "Binding to a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln]
synonym: "type 1 metabotropic GABA receptor ligand" NARROW []
is_a: GO:0031795 ! G protein-coupled GABA receptor binding

[Term]
id: GO:0031797
name: type 2 metabotropic GABA receptor binding
namespace: molecular_function
def: "Binding to a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln]
synonym: "type 2 metabotropic GABA receptor ligand" NARROW []
is_a: GO:0031795 ! G protein-coupled GABA receptor binding

[Term]
id: GO:0031798
name: type 1 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 1 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031799
name: type 2 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 2 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031800
name: type 3 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 3 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031801
name: type 4 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 4 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031802
name: type 5 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 5 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031803
name: type 6 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 6 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031804
name: type 7 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 7 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031805
name: type 8 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 8 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G protein-coupled glutamate receptor binding

[Term]
id: GO:0031806
name: G protein-coupled histamine receptor binding
namespace: molecular_function
def: "Binding to a G protein-coupled (metabotropic) histamine receptor." [GOC:mah, GOC:nln, PMID:12679144]
synonym: "G-protein coupled histamine receptor binding" EXACT []
synonym: "metabotropic histamine receptor binding" EXACT [GOC:bf]
synonym: "metabotropic histamine receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031807
name: H1 histamine receptor binding
namespace: molecular_function
def: "Binding to a H1 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H1 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G protein-coupled histamine receptor binding

[Term]
id: GO:0031808
name: H2 histamine receptor binding
namespace: molecular_function
def: "Binding to a H2 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H2 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G protein-coupled histamine receptor binding

[Term]
id: GO:0031809
name: H3 histamine receptor binding
namespace: molecular_function
def: "Binding to a H3 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H3 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G protein-coupled histamine receptor binding

[Term]
id: GO:0031810
name: H4 histamine receptor binding
namespace: molecular_function
def: "Binding to a H4 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H4 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G protein-coupled histamine receptor binding

[Term]
id: GO:0031811
name: G protein-coupled nucleotide receptor binding
namespace: molecular_function
def: "Binding to a G protein-coupled (metabotropic) nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "G-protein coupled nucleotide receptor binding" EXACT []
synonym: "metabotropic nucleotide receptor binding" EXACT [GOC:bf]
synonym: "metabotropic nucleotide receptor ligand" NARROW []
synonym: "P2Y receptor binding" EXACT []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031812
name: P2Y1 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y1 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031813
name: P2Y2 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y2 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031814
name: P2Y4 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y4 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031815
name: P2Y5 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y5 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031816
name: P2Y6 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y6 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031817
name: P2Y8 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y8 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031818
name: P2Y9 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y9 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031819
name: P2Y10 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y10 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031820
name: P2Y11 nucleotide receptor binding
namespace: molecular_function
def: "Binding to a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y11 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding

[Term]
id: GO:0031821
name: G protein-coupled serotonin receptor binding
namespace: molecular_function
def: "Binding to a metabotropic serotonin receptor." [GOC:mah, GOC:nln]
synonym: "G-protein coupled serotonin receptor binding" EXACT []
synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT []
synonym: "metabotropic serotonin receptor binding" EXACT [GOC:bf]
synonym: "metabotropic serotonin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031822
name: type 1B serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 1B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1B receptor binding" EXACT []
synonym: "type 1B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031823
name: type 1D serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 1D serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1D receptor binding" EXACT []
synonym: "type 1D serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031824
name: type 1E serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 1E serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1E receptor binding" EXACT []
synonym: "type 1E serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031825
name: type 1F serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 1F serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1F receptor binding" EXACT []
synonym: "type 1F serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031826
name: type 2A serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 2A serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2A receptor binding" EXACT []
synonym: "type 2A serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031827
name: type 2B serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 2B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2B receptor binding" EXACT []
synonym: "type 2B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031828
name: type 2C serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 2C serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2C receptor binding" EXACT []
synonym: "type 2C serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031829
name: type 4 serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 4 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 4 receptor binding" EXACT []
synonym: "type 4 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031830
name: type 5A serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 5A serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 5A receptor binding" EXACT []
synonym: "type 5A serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031831
name: type 5B serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 5B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 5B receptor binding" EXACT []
synonym: "type 5B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031832
name: type 6 serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 6 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 6 receptor binding" EXACT []
synonym: "type 6 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031833
name: type 7 serotonin receptor binding
namespace: molecular_function
def: "Binding to a type 7 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 7 receptor binding" EXACT []
synonym: "type 7 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G protein-coupled serotonin receptor binding

[Term]
id: GO:0031834
name: neurokinin receptor binding
namespace: molecular_function
def: "Binding to a neurokinin receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031835
name: substance P receptor binding
namespace: molecular_function
def: "Binding to a substance P receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-1 receptor binding" EXACT []
synonym: "substance P receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031836
name: neuromedin K receptor binding
namespace: molecular_function
def: "Binding to a neuromedin K receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-B receptor binding" EXACT []
synonym: "neuromedin K receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031837
name: substance K receptor binding
namespace: molecular_function
def: "Binding to a substance K receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-A receptor binding" EXACT []
synonym: "substance K receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031838
name: haptoglobin-hemoglobin complex
namespace: cellular_component
def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0031839
name: type 1 neuromedin U receptor binding
namespace: molecular_function
def: "Binding to a type 1 neuromedin U receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neuromedin U receptor ligand" NARROW []
is_a: GO:0042922 ! neuromedin U receptor binding

[Term]
id: GO:0031840
name: type 2 neuromedin U receptor binding
namespace: molecular_function
def: "Binding to a type 2 neuromedin U receptor." [GOC:mah, GOC:nln]
synonym: "type 2 neuromedin U receptor ligand" NARROW []
is_a: GO:0042922 ! neuromedin U receptor binding

[Term]
id: GO:0031841
name: neuropeptide Y receptor binding
namespace: molecular_function
def: "Binding to a neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "neuropeptide Y receptor ligand" NARROW []
synonym: "NPY receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031842
name: type 1 neuropeptide Y receptor binding
namespace: molecular_function
def: "Binding to a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031843
name: type 2 neuropeptide Y receptor binding
namespace: molecular_function
def: "Binding to a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 2 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031844
name: type 4 neuropeptide Y receptor binding
namespace: molecular_function
def: "Binding to a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "pancreatic polypeptide receptor binding" EXACT []
synonym: "type 4 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031845
name: type 5 neuropeptide Y receptor binding
namespace: molecular_function
def: "Binding to a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 5 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031846
name: neurotensin receptor binding
namespace: molecular_function
def: "Binding to a neurotensin receptor." [GOC:mah, GOC:nln]
synonym: "neurotensin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031847
name: type 1 neurotensin receptor binding
namespace: molecular_function
def: "Binding to a type 1 neurotensin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neurotensin receptor ligand" NARROW []
is_a: GO:0031846 ! neurotensin receptor binding

[Term]
id: GO:0031848
name: protection from non-homologous end joining at telomere
namespace: biological_process
def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah]
synonym: "protection from NHEJ-mediated telomere fusion" EXACT []
is_a: GO:0043247 ! telomere maintenance in response to DNA damage
relationship: part_of GO:0016233 ! telomere capping

[Term]
id: GO:0031849
name: olfactory receptor binding
namespace: molecular_function
def: "Binding to an olfactory receptor." [GOC:mah, GOC:nln]
synonym: "olfactory receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031850
name: delta-type opioid receptor binding
namespace: molecular_function
def: "Binding to a delta-type opioid receptor." [GOC:mah, GOC:nln]
synonym: "delta-type opioid receptor ligand" NARROW []
synonym: "enkephalin receptor binding" RELATED [GOC:sl]
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031851
name: kappa-type opioid receptor binding
namespace: molecular_function
def: "Binding to a kappa-type opioid receptor." [GOC:mah, GOC:nln]
synonym: "dynorphin receptor binding" RELATED []
synonym: "kappa-type opioid receptor ligand" NARROW [GOC:sl]
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031852
name: mu-type opioid receptor binding
namespace: molecular_function
def: "Binding to a mu-type opioid receptor." [GOC:mah, GOC:nln, GOC:sl]
synonym: "morphine receptor binding" RELATED [GOC:sl]
synonym: "mu-type opioid receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031853
name: nociceptin receptor binding
namespace: molecular_function
def: "Binding to a nociceptin receptor." [GOC:mah, GOC:nln]
synonym: "nociceptin receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031854
name: orexigenic neuropeptide QRFP receptor binding
namespace: molecular_function
def: "Binding to an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln]
synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031855
name: oxytocin receptor binding
namespace: molecular_function
def: "Binding to an oxytocin receptor." [GOC:mah, GOC:nln]
synonym: "oxytocin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031856
name: parathyroid hormone receptor binding
namespace: molecular_function
def: "Binding to a parathyroid hormone receptor." [GOC:mah, GOC:nln]
synonym: "parathyroid hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031857
name: type 1 parathyroid hormone receptor binding
namespace: molecular_function
def: "Binding to a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 1 parathyroid hormone receptor ligand" NARROW []
is_a: GO:0031856 ! parathyroid hormone receptor binding

[Term]
id: GO:0031858
name: pituitary adenylate cyclase-activating polypeptide receptor binding
namespace: molecular_function
def: "Binding to a pituitary adenylate cyclase-activating polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "PACAP receptor binding" EXACT []
synonym: "pituitary adenylate cyclase activating peptide receptor binding" EXACT [GOC:dph, GOC:tb]
synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031859
name: platelet activating factor receptor binding
namespace: molecular_function
def: "Binding to a platelet activating factor receptor." [GOC:mah, GOC:nln]
synonym: "platelet activating factor receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031860
name: telomeric 3' overhang formation
namespace: biological_process
def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639]
synonym: "telomere 3'-end processing" EXACT [GOC:mah, GOC:vw]
synonym: "telomere end processing" RELATED [GOC:mah, GOC:vw]
is_a: GO:0022616 ! DNA strand elongation
relationship: part_of GO:0016233 ! telomere capping

[Term]
id: GO:0031861
name: prolactin-releasing peptide receptor binding
namespace: molecular_function
def: "Binding to a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln]
synonym: "prolactin-releasing peptide receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031862
name: prostanoid receptor binding
namespace: molecular_function
def: "Binding to a prostanoid receptor." [GOC:mah, GOC:nln]
synonym: "prostanoid receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031863
name: prostaglandin D2 receptor binding
namespace: molecular_function
def: "Binding to a prostaglandin D2 receptor." [GOC:mah, GOC:nln]
synonym: "prostaglandin D2 receptor ligand" NARROW []
synonym: "prostanoid DP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031864
name: EP1 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Binding to an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP1 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031865
name: EP2 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Binding to an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP2 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031866
name: EP3 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Binding to an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP3 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031867
name: EP4 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Binding to an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP4 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031868
name: prostaglandin F2-alpha receptor binding
namespace: molecular_function
def: "Binding to a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln]
synonym: "prostaglandin F2-alpha receptor ligand" NARROW []
synonym: "prostanoid FP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031869
name: prostacyclin receptor binding
namespace: molecular_function
def: "Binding to a prostacyclin receptor." [GOC:mah, GOC:nln]
synonym: "prostacyclin receptor ligand" NARROW []
synonym: "prostanoid IP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031870
name: thromboxane A2 receptor binding
namespace: molecular_function
def: "Binding to a thromboxane A2 receptor." [GOC:mah, GOC:nln]
synonym: "prostanoid TP receptor binding" EXACT []
synonym: "thromboxane A2 receptor ligand" NARROW []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031871
name: proteinase activated receptor binding
namespace: molecular_function
def: "Binding to a proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "proteinase activated receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031872
name: type 1 proteinase activated receptor binding
namespace: molecular_function
def: "Binding to a type 1 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "thrombin receptor binding" EXACT []
synonym: "type 1 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031873
name: type 2 proteinase activated receptor binding
namespace: molecular_function
def: "Binding to a type 2 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 2 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031874
name: type 3 proteinase activated receptor binding
namespace: molecular_function
def: "Binding to a type 3 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 3 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031875
name: type 4 proteinase activated receptor binding
namespace: molecular_function
def: "Binding to a type 4 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 4 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031876
name: secretin receptor binding
namespace: molecular_function
def: "Binding to a secretin receptor." [GOC:mah, GOC:nln]
synonym: "secretin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031877
name: somatostatin receptor binding
namespace: molecular_function
def: "Binding to a somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "somatostatin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031878
name: type 1 somatostatin receptor binding
namespace: molecular_function
def: "Binding to a type 1 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031879
name: type 2 somatostatin receptor binding
namespace: molecular_function
def: "Binding to a type 2 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031880
name: type 3 somatostatin receptor binding
namespace: molecular_function
def: "Binding to a type 3 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031881
name: type 4 somatostatin receptor binding
namespace: molecular_function
def: "Binding to a type 4 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 4 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031882
name: type 5 somatostatin receptor binding
namespace: molecular_function
def: "Binding to a type 5 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 5 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031883
name: taste receptor binding
namespace: molecular_function
def: "Binding to a taste receptor." [GOC:mah, GOC:nln]
synonym: "taste receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031884
name: type 1 member 1 taste receptor binding
namespace: molecular_function
def: "Binding to a type 1 member 1 taste receptor." [GOC:mah, GOC:nln]
synonym: "type 1 member 1 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031885
name: type 1 member 2 taste receptor binding
namespace: molecular_function
def: "Binding to a type 1 member 2 taste receptor." [GOC:mah, GOC:nln]
synonym: "type 1 member 2 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031886
name: type 1 member 3 taste receptor binding
namespace: molecular_function
def: "Binding to a type 1 member 3 taste receptor." [GOC:mah, GOC:nln]
synonym: "sweet taste receptor binding" EXACT []
synonym: "type 1 member 3 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031887
name: lipid droplet transport along microtubule
namespace: biological_process
def: "The directed movement of a lipid droplet along a microtubule, mediated by motor proteins." [PMID:9491895]
synonym: "adiposome transport along microtubule" EXACT []
synonym: "lipid body transport along microtubule" EXACT []
synonym: "lipid particle transport along microtubule" EXACT []
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0031889
name: urotensin receptor binding
namespace: molecular_function
def: "Binding to a urotensin receptor." [GOC:mah, GOC:nln]
synonym: "urotensin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031890
name: vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Binding to a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "VIP receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031891
name: type 1 vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Binding to a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "type 2 PACAP receptor binding" EXACT []
is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding

[Term]
id: GO:0031892
name: type 2 vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Binding to a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "type 3 PACAP receptor binding" EXACT []
is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding

[Term]
id: GO:0031893
name: vasopressin receptor binding
namespace: molecular_function
def: "Binding to a vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "vasopressin receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0031894
name: V1A vasopressin receptor binding
namespace: molecular_function
def: "Binding to a V1A vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V1A vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031895
name: V1B vasopressin receptor binding
namespace: molecular_function
def: "Binding to a V1B vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V1B vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031896
name: V2 vasopressin receptor binding
namespace: molecular_function
def: "Binding to a V2 vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V2 vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031897
name: Tic complex
namespace: cellular_component
def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016]
synonym: "chloroplast inner membrane translocase complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031898
name: chromoplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009509 ! chromoplast

[Term]
id: GO:0031899
name: chromoplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031900
name: chromoplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz]
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031901
name: early endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an early endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031902
name: late endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a late endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031903
name: microbody membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a microbody." [GOC:mah]
is_a: GO:0042579 ! microbody
is_a: GO:0098588 ! bounding membrane of organelle

[Term]
id: GO:0031904
name: endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endosome." [GOC:mah]
xref: NIF_Subcellular:sao1547508851
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0031905
name: early endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an early endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031906
name: late endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a late endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031907
name: microbody lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a microbody." [GOC:mah]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0042579 ! microbody

[Term]
id: GO:0031908
name: glyoxysomal lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah]
is_a: GO:0005782 ! peroxisomal matrix

[Term]
id: GO:0031910
name: cytostome
namespace: cellular_component
def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189]
xref: Wikipedia:Cytostome
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0031911
name: cytoproct
namespace: cellular_component
def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189, PMID:23317460, PMID:27889663]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0031912
name: oral apparatus
namespace: cellular_component
def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189]
comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals.
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0031913
name: contractile vacuole pore
namespace: cellular_component
def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031914
name: negative regulation of synaptic plasticity
namespace: biological_process
def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah]
synonym: "down regulation of synaptic plasticity" EXACT []
synonym: "down-regulation of synaptic plasticity" EXACT []
synonym: "downregulation of synaptic plasticity" EXACT []
synonym: "inhibition of synaptic plasticity" NARROW []
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031915
name: positive regulation of synaptic plasticity
namespace: biological_process
def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah]
synonym: "activation of synaptic plasticity" NARROW []
synonym: "stimulation of synaptic plasticity" NARROW []
synonym: "up regulation of synaptic plasticity" EXACT []
synonym: "up-regulation of synaptic plasticity" EXACT []
synonym: "upregulation of synaptic plasticity" EXACT []
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031916
name: regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031917
name: negative regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
synonym: "down regulation of synaptic metaplasticity" EXACT []
synonym: "down-regulation of synaptic metaplasticity" EXACT []
synonym: "downregulation of synaptic metaplasticity" EXACT []
synonym: "inhibition of synaptic metaplasticity" NARROW []
is_a: GO:0031914 ! negative regulation of synaptic plasticity
is_a: GO:0031916 ! regulation of synaptic metaplasticity

[Term]
id: GO:0031918
name: positive regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
synonym: "activation of synaptic metaplasticity" NARROW []
synonym: "stimulation of synaptic metaplasticity" NARROW []
synonym: "up regulation of synaptic metaplasticity" EXACT []
synonym: "up-regulation of synaptic metaplasticity" EXACT []
synonym: "upregulation of synaptic metaplasticity" EXACT []
is_a: GO:0031915 ! positive regulation of synaptic plasticity
is_a: GO:0031916 ! regulation of synaptic metaplasticity

[Term]
id: GO:0031919
name: vitamin B6 transport
namespace: biological_process
def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0031920
name: pyridoxal transport
namespace: biological_process
def: "The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031921
name: pyridoxal phosphate transport
namespace: biological_process
def: "The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031922
name: pyridoxamine transport
namespace: biological_process
def: "The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031923
name: pyridoxine transport
namespace: biological_process
def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031924
name: vitamin B6 transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other." [GOC:mah]
synonym: "vitamin B6 transporter activity" RELATED []
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0031925
name: pyridoxal transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxal transporter activity" BROAD []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0031926
name: pyridoxal phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0031927
name: pyridoxamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0031928
name: pyridoxine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxine transporter activity" BROAD []
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0031929
name: TOR signaling
namespace: biological_process
def: "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]
comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
synonym: "target of rapamycin signaling pathway" EXACT []
synonym: "target of rapamycin signalling pathway" EXACT []
synonym: "TOR signal transduction" EXACT [GOC:signaling]
synonym: "TOR signaling cascade" RELATED [GOC:signaling]
synonym: "TOR signaling pathway" EXACT []
synonym: "TOR signalling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0031930
name: mitochondria-nucleus signaling pathway
namespace: biological_process
def: "The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799]
synonym: "mitochondria-nucleus signal transduction" EXACT [GOC:signaling]
synonym: "mitochondrial signaling pathway" EXACT []
synonym: "mitochondrial signalling pathway" EXACT []
synonym: "retrograde response" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0031931
name: TORC1 complex
namespace: cellular_component
def: "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]
synonym: "dTOR/dRaptor complex" NARROW [PMID:17183368]
synonym: "dTORC1" NARROW [PMID:17183368]
synonym: "mTORC1" NARROW [PMID:18765678, PMID:21548787]
synonym: "nutrient sensitive complex" EXACT []
synonym: "rapamycin and nutrient-sensitive TOR complex" EXACT [PMID:21548787]
synonym: "TOR complex 1" EXACT []
synonym: "TORC 1 complex" EXACT []
synonym: "TORC1" EXACT [PMID:21548787]
xref: Wikipedia:MTORC1
is_a: GO:0038201 ! TOR complex

[Term]
id: GO:0031932
name: TORC2 complex
namespace: cellular_component
def: "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]
synonym: "mTORC2" NARROW [PMID:20496258, PMID:21548787]
synonym: "rapamycin and nutrient-insensitive TOR complex" EXACT [PMID:21548787]
synonym: "TOR complex 2" EXACT []
synonym: "TORC 2 complex" EXACT []
synonym: "TORC2" EXACT [PMID:21548787]
xref: Wikipedia:MTORC1
is_a: GO:0038201 ! TOR complex

[Term]
id: GO:0031933
name: obsolete telomeric heterochromatin
namespace: cellular_component
def: "OBSOLETE. Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah]
comment: This term was obsoleted because there is no heterochromatin at the telomere and the term had been used inconsistently.
synonym: "telomeric chromatin" BROAD [GOC:pr]
is_obsolete: true

[Term]
id: GO:0031934
name: mating-type region heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0031935
name: obsolete regulation of chromatin silencing
namespace: biological_process
def: "OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways.
synonym: "regulation of heterochromatic silencing" RELATED []
is_obsolete: true

[Term]
id: GO:0031936
name: obsolete negative regulation of chromatin silencing
namespace: biological_process
alt_id: GO:0006345
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways.
synonym: "down regulation of chromatin silencing" EXACT []
synonym: "down-regulation of chromatin silencing" EXACT []
synonym: "downregulation of chromatin silencing" EXACT []
synonym: "inhibition of chromatin silencing" NARROW []
synonym: "loss of chromatin silencing" EXACT []
synonym: "negative regulation of heterochromatic silencing" EXACT []
is_obsolete: true

[Term]
id: GO:0031937
name: obsolete positive regulation of chromatin silencing
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah]
comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways.
synonym: "activation of chromatin silencing" NARROW []
synonym: "positive regulation of heterochromatic silencing" EXACT []
synonym: "stimulation of chromatin silencing" NARROW []
synonym: "up regulation of chromatin silencing" EXACT []
synonym: "up-regulation of chromatin silencing" EXACT []
synonym: "upregulation of chromatin silencing" EXACT []
is_obsolete: true

[Term]
id: GO:0031938
name: obsolete regulation of chromatin silencing at telomere
namespace: biological_process
def: "OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah]
comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
synonym: "regulation of heterochromatic silencing at telomere" EXACT []
is_obsolete: true
consider: GO:0031509

[Term]
id: GO:0031939
name: obsolete negative regulation of chromatin silencing at telomere
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
synonym: "down regulation of chromatin silencing at telomere" EXACT []
synonym: "down-regulation of chromatin silencing at telomere" EXACT []
synonym: "downregulation of chromatin silencing at telomere" EXACT []
synonym: "inhibition of chromatin silencing at telomere" NARROW []
synonym: "negative regulation of heterochromatic silencing at telomere" EXACT []
is_obsolete: true

[Term]
id: GO:0031940
name: obsolete positive regulation of chromatin silencing at telomere
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
synonym: "activation of chromatin silencing at telomere" NARROW []
synonym: "positive regulation of heterochromatic silencing at telomere" EXACT []
synonym: "stimulation of chromatin silencing at telomere" NARROW []
synonym: "up regulation of chromatin silencing at telomere" EXACT []
synonym: "up-regulation of chromatin silencing at telomere" EXACT []
synonym: "upregulation of chromatin silencing at telomere" EXACT []
is_obsolete: true

[Term]
id: GO:0031941
name: filamentous actin
namespace: cellular_component
def: "A two-stranded helical polymer of the protein actin." [GOC:mah]
comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'.
synonym: "F-actin" EXACT []
xref: Wikipedia:Actin
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005884 ! actin filament

[Term]
id: GO:0031942
name: i-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:0031943
name: regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "regulation of glucocorticoid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031944
name: negative regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid metabolic process" EXACT []
synonym: "down-regulation of glucocorticoid metabolic process" EXACT []
synonym: "downregulation of glucocorticoid metabolic process" EXACT []
synonym: "inhibition of glucocorticoid metabolic process" NARROW []
synonym: "negative regulation of glucocorticoid metabolism" EXACT []
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031945
name: positive regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid metabolic process" NARROW []
synonym: "positive regulation of glucocorticoid metabolism" EXACT []
synonym: "stimulation of glucocorticoid metabolic process" NARROW []
synonym: "up regulation of glucocorticoid metabolic process" EXACT []
synonym: "up-regulation of glucocorticoid metabolic process" EXACT []
synonym: "upregulation of glucocorticoid metabolic process" EXACT []
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031946
name: regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031947
name: negative regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "downregulation of glucocorticoid biosynthetic process" EXACT []
synonym: "inhibition of glucocorticoid biosynthetic process" NARROW []
is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031948
name: positive regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid biosynthetic process" NARROW []
synonym: "stimulation of glucocorticoid biosynthetic process" NARROW []
synonym: "up regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "upregulation of glucocorticoid biosynthetic process" EXACT []
is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031949
name: regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031950
name: negative regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid catabolic process" EXACT []
synonym: "down-regulation of glucocorticoid catabolic process" EXACT []
synonym: "downregulation of glucocorticoid catabolic process" EXACT []
synonym: "inhibition of glucocorticoid catabolic process" NARROW []
is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process
is_a: GO:0031949 ! regulation of glucocorticoid catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031951
name: positive regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid catabolic process" NARROW []
synonym: "stimulation of glucocorticoid catabolic process" NARROW []
synonym: "up regulation of glucocorticoid catabolic process" EXACT []
synonym: "up-regulation of glucocorticoid catabolic process" EXACT []
synonym: "upregulation of glucocorticoid catabolic process" EXACT []
is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process
is_a: GO:0031949 ! regulation of glucocorticoid catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031952
name: regulation of protein autophosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid autophosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
relationship: regulates GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0031953
name: negative regulation of protein autophosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein amino acid autophosphorylation" EXACT []
synonym: "down-regulation of protein amino acid autophosphorylation" EXACT []
synonym: "downregulation of protein amino acid autophosphorylation" EXACT []
synonym: "inhibition of protein amino acid autophosphorylation" NARROW []
synonym: "negative regulation of protein amino acid autophosphorylation" EXACT [GOC:bf]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0031952 ! regulation of protein autophosphorylation
relationship: negatively_regulates GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0031954
name: positive regulation of protein autophosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein amino acid autophosphorylation" NARROW []
synonym: "positive regulation of protein amino acid autophosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid autophosphorylation" NARROW []
synonym: "up regulation of protein amino acid autophosphorylation" EXACT []
synonym: "up-regulation of protein amino acid autophosphorylation" EXACT []
synonym: "upregulation of protein amino acid autophosphorylation" EXACT []
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0031952 ! regulation of protein autophosphorylation
relationship: positively_regulates GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0031955
name: short-chain fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [PMID:34904027, RHEA:52860]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "short-chain fatty acid activation" RELATED []
synonym: "short-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf]
synonym: "short-chain-fatty-acid-CoA ligase activity" EXACT []
xref: RHEA:52860
is_a: GO:0120515 ! fatty acid-CoA ligase activity

[Term]
id: GO:0031956
name: medium-chain fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:48340]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "medium-chain fatty acid activation" RELATED []
synonym: "medium-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf]
synonym: "medium-chain-fatty-acid-CoA ligase activity" EXACT []
xref: EC:6.2.1.2
xref: Reactome:R-HSA-8875013 "ACSM3,ACSM6 ligate CoA to BUT"
xref: RHEA:48340
is_a: GO:0120515 ! fatty acid-CoA ligase activity

[Term]
id: GO:0031957
name: very long-chain fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:18024425, RHEA:54536]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very-long-chain fatty acid activation" RELATED []
synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT []
synonym: "very-long-chain-fatty-acid-CoA ligase activity" EXACT []
xref: Reactome:R-HSA-5695957 "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA"
xref: Reactome:R-HSA-5696007 "ACSF3 ligates CoA-SH to VLCFA"
xref: Reactome:R-HSA-8875077 "SLC27A3 ligates CoA-SH to VLCFA"
xref: Reactome:R-HSA-9914143 "SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH"
xref: RHEA:54536
is_a: GO:0120515 ! fatty acid-CoA ligase activity

[Term]
id: GO:0031958
name: nuclear receptor-mediated corticosteroid signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a corticosteroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:11027914, PMID:12606724]
synonym: "corticosteroid receptor signalling pathway" BROAD []
synonym: "intracellular corticosteroid receptor signaling pathway" EXACT []
is_a: GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0031959
name: nuclear receptor-mediated mineralocorticoid signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a mineralocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:11027914, PMID:12606724]
synonym: "intracellular mineralocorticoid receptor signaling pathway" EXACT []
synonym: "mineralocorticoid receptor signaling pathway" BROAD []
synonym: "mineralocorticoid receptor signalling pathway" BROAD []
is_a: GO:0031958 ! nuclear receptor-mediated corticosteroid signaling pathway

[Term]
id: GO:0031960
name: response to corticosteroid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914]
synonym: "response to corticosteroid stimulus" EXACT [GOC:dos]
is_a: GO:0048545 ! response to steroid hormone

[Term]
id: GO:0031961
name: nuclear cortisol receptor binding
namespace: molecular_function
def: "Binding to a nuclear cortisol receptor." [GOC:mah, PMID:12511169]
synonym: "cortisol receptor binding" BROAD []
is_a: GO:0035259 ! nuclear glucocorticoid receptor binding

[Term]
id: GO:0031962
name: nuclear mineralocorticoid receptor binding
namespace: molecular_function
def: "Binding to a nuclear mineralocorticoid receptor." [GOC:mah, PMID:12511169]
synonym: "mineralocorticoid receptor binding" BROAD []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0031963
name: nuclear cortisol receptor activity
namespace: molecular_function
def: "A nuclear receptor activity regulated by cortisol binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:mah, PMID:12511169]
synonym: "cortisol receptor activity" BROAD []
is_a: GO:0004883 ! nuclear glucocorticoid receptor activity

[Term]
id: GO:0031964
name: beta-alanyl-histamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine." [GOC:rc, PMID:16299587]
synonym: "carcinine hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0031965
name: nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
xref: NIF_Subcellular:sao1687101204
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0031966
name: mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
xref: NIF_Subcellular:sao1045389829
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0031967
name: organelle envelope
namespace: cellular_component
def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]
subset: goslim_mouse
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043227 ! membrane-bounded organelle
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0031968
name: organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah]
is_a: GO:0019867 ! outer membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031969
name: chloroplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz]
xref: Wikipedia:Chloroplast_membrane
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031970
name: organelle envelope lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah]
synonym: "organelle intermembrane space" EXACT []
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031972
name: chloroplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah]
synonym: "chloroplast envelope lumen" EXACT []
is_a: GO:0009529 ! plastid intermembrane space
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031973
name: chromoplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah]
synonym: "chromoplast envelope lumen" EXACT []
is_a: GO:0009529 ! plastid intermembrane space
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0031974
name: membrane-enclosed lumen
namespace: cellular_component
def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0031975
name: obsolete envelope
namespace: cellular_component
def: "OBSOLETE. A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz]
comment: The reason for obsoletion is that it is an unnecessary (and confusing) grouping term: mixes cell envelope and organelle envelopes.
is_obsolete: true

[Term]
id: GO:0031976
name: plastid thylakoid
namespace: cellular_component
def: "Any thylakoid within a plastid." [GOC:pz]
is_a: GO:0009579 ! thylakoid
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0031977
name: thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0031978
name: plastid thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0031979
name: plasma membrane-derived thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu]
synonym: "plasma membrane thylakoid lumen" EXACT []
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0031981
name: nuclear lumen
namespace: cellular_component
def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0031982
name: vesicle
namespace: cellular_component
alt_id: GO:0031988
def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]
subset: goslim_pir
synonym: "membrane-bounded vesicle" RELATED []
synonym: "membrane-enclosed vesicle" RELATED []
xref: NIF_Subcellular:sao221389602
xref: Wikipedia:Vesicle_(biology)
is_a: GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031983
name: vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]
xref: NIF_Subcellular:sao797538226
is_a: GO:0043233 ! organelle lumen
relationship: part_of GO:0031982 ! vesicle

[Term]
id: GO:0031984
name: organelle subcompartment
namespace: cellular_component
def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz]
comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles.
synonym: "suborganelle compartment" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043227 ! membrane-bounded organelle
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0031985
name: Golgi cisterna
namespace: cellular_component
def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]
synonym: "Golgi apparatus cisterna" EXACT []
synonym: "Golgi lamellae" RELATED [NIF_Subcellular:sao561419532]
xref: NIF_Subcellular:sao561419532
is_a: GO:0098791 ! Golgi apparatus subcompartment
relationship: part_of GO:0005795 ! Golgi stack

[Term]
id: GO:0031986
name: proteinoplast
namespace: cellular_component
def: "A leucoplast in which protein is stored." [GOC:pz]
xref: Wikipedia:Proteinoplast
is_a: GO:0009516 ! leucoplast

[Term]
id: GO:0031987
name: locomotion involved in locomotory behavior
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
synonym: "locomotion during locomotory behaviour" EXACT []
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0007626 ! locomotory behavior

[Term]
id: GO:0031989
name: bombesin receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah]
synonym: "bombesin receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0031990
name: mRNA export from nucleus in response to heat stress
namespace: biological_process
def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw]
synonym: "mRNA export from cell nucleus during heat stress" EXACT []
synonym: "mRNA export from nucleus during heat stress" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006406 ! mRNA export from nucleus
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0034605 ! cellular response to heat
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0031991
name: regulation of actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of actomyosin contractile ring constriction" EXACT [GOC:vw]
synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "regulation of contractile ring contraction involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0032954 ! regulation of cytokinetic process
relationship: regulates GO:0000916 ! actomyosin contractile ring contraction

[Term]
id: GO:0031992
name: energy transducer activity
namespace: molecular_function
def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators]
subset: goslim_pir
synonym: "light harvesting activity" RELATED []
synonym: "photon capture" RELATED []
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0031993
name: light transducer activity
namespace: molecular_function
def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg]
is_a: GO:0031992 ! energy transducer activity

[Term]
id: GO:0031994
name: insulin-like growth factor I binding
namespace: molecular_function
def: "Binding to insulin-like growth factor I." [GOC:mah]
subset: goslim_chembl
synonym: "IGF-I binding" EXACT []
is_a: GO:0005520 ! insulin-like growth factor binding

[Term]
id: GO:0031995
name: insulin-like growth factor II binding
namespace: molecular_function
def: "Binding to insulin-like growth factor II." [GOC:mah]
subset: goslim_chembl
synonym: "IGF-II binding" EXACT []
is_a: GO:0005520 ! insulin-like growth factor binding

[Term]
id: GO:0031996
name: thioesterase binding
namespace: molecular_function
def: "Binding to a thioesterase." [GOC:dl]
synonym: "thiolesterase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0031997
name: obsolete N-terminal myristoylation domain binding
namespace: molecular_function
def: "OBSOLETE. Binding to the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291]
comment: It is beyond GO scope.
is_obsolete: true
replaced_by: GO:0005515

[Term]
id: GO:0031998
name: regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah]
is_a: GO:0046320 ! regulation of fatty acid oxidation
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0031999
name: negative regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah]
synonym: "down regulation of fatty acid beta-oxidation" EXACT []
synonym: "down-regulation of fatty acid beta-oxidation" EXACT []
synonym: "downregulation of fatty acid beta-oxidation" EXACT []
synonym: "inhibition of fatty acid beta-oxidation" NARROW []
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
is_a: GO:0046322 ! negative regulation of fatty acid oxidation
is_a: GO:0050995 ! negative regulation of lipid catabolic process
relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0032000
name: positive regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah]
synonym: "activation of fatty acid beta-oxidation" NARROW []
synonym: "stimulation of fatty acid beta-oxidation" NARROW []
synonym: "up regulation of fatty acid beta-oxidation" EXACT []
synonym: "up-regulation of fatty acid beta-oxidation" EXACT []
synonym: "upregulation of fatty acid beta-oxidation" EXACT []
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
is_a: GO:0046321 ! positive regulation of fatty acid oxidation
is_a: GO:0050996 ! positive regulation of lipid catabolic process
relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0032001
name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan." [EC:2.4.1.24]
synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT []
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT []
synonym: "D-glucosyltransferase" BROAD []
synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24]
synonym: "T-enzyme" NARROW []
xref: EC:2.4.1.24
xref: MetaCyc:2.4.1.24-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0032002
name: interleukin-28 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1)." [GOC:rph]
synonym: "IL-28 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0032003
name: interleukin-28 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-28 receptor." [GOC:rph]
synonym: "IL-28" NARROW []
synonym: "interleukin-28 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0032005
name: signal transduction involved in positive regulation of conjugation with cellular fusion
namespace: biological_process
def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion

[Term]
id: GO:0032006
name: regulation of TOR signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]
synonym: "regulation of target of rapamycin signaling pathway" EXACT []
synonym: "regulation of target of rapamycin signalling pathway" EXACT []
synonym: "regulation of TOR signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of TOR signaling pathway" EXACT []
synonym: "regulation of TOR signalling pathway" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0031929 ! TOR signaling

[Term]
id: GO:0032007
name: negative regulation of TOR signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]
synonym: "down regulation of TOR signaling pathway" EXACT []
synonym: "down-regulation of TOR signaling pathway" EXACT []
synonym: "downregulation of TOR signaling pathway" EXACT []
synonym: "inhibition of TOR signaling pathway" NARROW []
synonym: "negative regulation of target of rapamycin signaling pathway" EXACT []
synonym: "negative regulation of target of rapamycin signalling pathway" EXACT []
synonym: "negative regulation of TOR signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of TOR signaling pathway" EXACT []
synonym: "negative regulation of TOR signalling pathway" EXACT []
is_a: GO:0032006 ! regulation of TOR signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0031929 ! TOR signaling

[Term]
id: GO:0032008
name: positive regulation of TOR signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
synonym: "activation of TOR signaling pathway" NARROW []
synonym: "positive regulation of target of rapamycin signaling pathway" EXACT []
synonym: "positive regulation of target of rapamycin signalling pathway" EXACT []
synonym: "positive regulation of TOR signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of TOR signaling pathway" EXACT []
synonym: "positive regulation of TOR signalling pathway" EXACT []
synonym: "stimulation of TOR signaling pathway" NARROW []
synonym: "up regulation of TOR signaling pathway" EXACT []
synonym: "up-regulation of TOR signaling pathway" EXACT []
synonym: "upregulation of TOR signaling pathway" EXACT []
is_a: GO:0032006 ! regulation of TOR signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0031929 ! TOR signaling

[Term]
id: GO:0032009
name: early phagosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753]
synonym: "early phagocytic vesicle" EXACT []
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032010
name: phagolysosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753, PMID:14733906]
synonym: "late phagocytic vesicle" RELATED []
synonym: "late phagosome" RELATED []
xref: Wikipedia:Phagolysosome
is_a: GO:0005767 ! secondary lysosome
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032011
name: ARF protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the ARF subfamily relays a signal." [GOC:mah]
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0032012
name: regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032013
name: negative regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
synonym: "down regulation of ARF protein signal transduction" EXACT []
synonym: "down-regulation of ARF protein signal transduction" EXACT []
synonym: "downregulation of ARF protein signal transduction" EXACT []
synonym: "inhibition of ARF protein signal transduction" NARROW []
is_a: GO:0032012 ! regulation of ARF protein signal transduction
is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction
relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032014
name: positive regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
synonym: "activation of ARF protein signal transduction" NARROW []
synonym: "stimulation of ARF protein signal transduction" NARROW []
synonym: "up regulation of ARF protein signal transduction" EXACT []
synonym: "up-regulation of ARF protein signal transduction" EXACT []
synonym: "upregulation of ARF protein signal transduction" EXACT []
is_a: GO:0032012 ! regulation of ARF protein signal transduction
is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction
relationship: positively_regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032015
name: obsolete regulation of Ran protein signal transduction
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
comment: This term was obsoleted because this process is not known to be regulated.
is_obsolete: true
replaced_by: GO:0031291

[Term]
id: GO:0032016
name: obsolete negative regulation of Ran protein signal transduction
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
comment: This term was obsoleted because this process is not known to be regulated.
synonym: "down regulation of Ran protein signal transduction" EXACT []
synonym: "down-regulation of Ran protein signal transduction" EXACT []
synonym: "downregulation of Ran protein signal transduction" EXACT []
synonym: "inhibition of Ran protein signal transduction" NARROW []
is_obsolete: true
replaced_by: GO:0031291

[Term]
id: GO:0032017
name: obsolete positive regulation of Ran protein signal transduction
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
comment: This term was obsoleted because this process is not known to be regulated.
synonym: "activation of Ran protein signal transduction" NARROW []
synonym: "stimulation of Ran protein signal transduction" NARROW []
synonym: "up regulation of Ran protein signal transduction" EXACT []
synonym: "up-regulation of Ran protein signal transduction" EXACT []
synonym: "upregulation of Ran protein signal transduction" EXACT []
is_obsolete: true
replaced_by: GO:0031291

[Term]
id: GO:0032018
name: 2-methylbutanal reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903]
synonym: "2-methylbutanal reductase (NADP) activity" EXACT []
synonym: "2-methylbutanol:NADP oxidoreductase activity" EXACT []
synonym: "2-methylbutyraldehyde reductase (NADP) activity" EXACT []
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity

[Term]
id: GO:0032019
name: mitochondrial cloud
namespace: cellular_component
def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166]
synonym: "Balbiani body" EXACT []
synonym: "mitochondrial aggregate" RELATED []
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0032020
name: ISG15-protein conjugation
namespace: biological_process
def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah]
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0032021
name: NELF complex
namespace: cellular_component
def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062]
synonym: "negative elongation factor complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032023
name: trypsinogen activation
namespace: biological_process
def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah]
synonym: "cleavage of trypsinogen to trypsin" EXACT []
is_a: GO:0031638 ! zymogen activation

[Term]
id: GO:0032024
name: positive regulation of insulin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]
synonym: "activation of insulin secretion" NARROW []
synonym: "stimulation of insulin secretion" NARROW []
synonym: "up regulation of insulin secretion" EXACT []
synonym: "up-regulation of insulin secretion" EXACT []
synonym: "upregulation of insulin secretion" EXACT []
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0032025
name: response to cobalt ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion (Co2+) stimulus." [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0032026
name: response to magnesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0032027
name: myosin light chain binding
namespace: molecular_function
def: "Binding to a light chain of a myosin complex." [GOC:mah]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0032028
name: myosin head/neck binding
namespace: molecular_function
def: "Binding to the head/neck region of a myosin heavy chain." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032029
name: myosin tail binding
namespace: molecular_function
def: "Binding to the tail region of a myosin heavy chain." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032030
name: myosin I light chain binding
namespace: molecular_function
def: "Binding to a light chain of a myosin I complex." [GOC:mah]
is_a: GO:0017024 ! myosin I binding
is_a: GO:0032027 ! myosin light chain binding

[Term]
id: GO:0032031
name: myosin I head/neck binding
namespace: molecular_function
def: "Binding to the head/neck region of a myosin I heavy chain." [GOC:mah]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0032037 ! myosin I heavy chain binding

[Term]
id: GO:0032032
name: myosin I tail binding
namespace: molecular_function
def: "Binding to the tail region of a myosin I heavy chain." [GOC:mah]
is_a: GO:0032029 ! myosin tail binding
is_a: GO:0032037 ! myosin I heavy chain binding

[Term]
id: GO:0032033
name: myosin II light chain binding
namespace: molecular_function
def: "Binding to a light chain of a myosin II complex." [GOC:mah]
is_a: GO:0032027 ! myosin light chain binding
is_a: GO:0045159 ! myosin II binding

[Term]
id: GO:0032034
name: myosin II head/neck binding
namespace: molecular_function
def: "Binding to the head/neck region of a myosin II heavy chain." [GOC:mah]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0032038 ! myosin II heavy chain binding

[Term]
id: GO:0032035
name: myosin II tail binding
namespace: molecular_function
def: "Binding to the tail region of a myosin II heavy chain." [GOC:mah]
is_a: GO:0032029 ! myosin tail binding
is_a: GO:0032038 ! myosin II heavy chain binding

[Term]
id: GO:0032036
name: myosin heavy chain binding
namespace: molecular_function
def: "Binding to a heavy chain of a myosin complex." [GOC:mah]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0032037
name: myosin I heavy chain binding
namespace: molecular_function
def: "Binding to a heavy chain of a myosin I complex." [GOC:mah]
is_a: GO:0017024 ! myosin I binding
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032038
name: myosin II heavy chain binding
namespace: molecular_function
def: "Binding to a heavy chain of a myosin II complex." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding
is_a: GO:0045159 ! myosin II binding

[Term]
id: GO:0032039
name: integrator complex
namespace: cellular_component
def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032040
name: small-subunit processome
namespace: cellular_component
def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]
synonym: "small subunit processome" EXACT []
synonym: "SSU processome" EXACT []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0032041
name: histone H3K14 deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K14 to NAD, producing nicotinamide." [PMID:28450737]
synonym: "NAD-dependent histone deacetylase activity (H3-K14 specific)" EXACT []
synonym: "NAD-dependent histone H3-K14 deacetylase activity" EXACT []
synonym: "NAD-dependent histone H3K14 deacetylase activity" EXACT []
is_a: GO:0017136 ! histone deacetylase activity, NAD-dependent
is_a: GO:0141050 ! histone H3K deacetylase activity

[Term]
id: GO:0032042
name: mitochondrial DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA metabolism" EXACT []
synonym: "mtDNA metabolic process" EXACT []
synonym: "mtDNA metabolism" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0000002 ! mitochondrial genome maintenance

[Term]
id: GO:0032043
name: mitochondrial DNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA breakdown" EXACT []
synonym: "mitochondrial DNA catabolism" EXACT []
synonym: "mitochondrial DNA degradation" EXACT []
synonym: "mtDNA breakdown" EXACT []
synonym: "mtDNA catabolic process" EXACT []
synonym: "mtDNA catabolism" EXACT []
synonym: "mtDNA degradation" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:0032044
name: DSIF complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865]
synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT []
synonym: "DRB sensitivity inducing factor complex" EXACT []
synonym: "Spt4-Spt5 complex" EXACT []
synonym: "Spt5-Spt4 complex" EXACT [GOC:vw]
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032045
name: guanyl-nucleotide exchange factor complex
namespace: cellular_component
def: "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah]
synonym: "guanine nucleotide exchange factor" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0032046
name: micropexophagy-specific membrane apparatus
namespace: cellular_component
def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611]
synonym: "micropexophagic apparatus" EXACT []
synonym: "MIPA" EXACT []
is_a: GO:0031984 ! organelle subcompartment
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0032047
name: mitosome
namespace: cellular_component
def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria." [GOC:giardia, PMID:10361303, PMID:14614504, PMID:24316280]
comment: In Giardia species, mitosomes are sometimes present between the two nuclei.
synonym: "crypton" EXACT []
xref: Wikipedia:Mitosome
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0032048
name: cardiolipin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]
synonym: "cardiolipin metabolism" EXACT []
synonym: "diphosphatidylglycerol metabolic process" RELATED []
synonym: "diphosphatidylglycerol metabolism" RELATED []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process

[Term]
id: GO:0032049
name: cardiolipin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]
synonym: "diphosphatidylglycerol biosynthesis" RELATED []
synonym: "diphosphatidylglycerol biosynthetic process" RELATED []
xref: MetaCyc:PWY-5269
is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process
is_a: GO:0032048 ! cardiolipin metabolic process

[Term]
id: GO:0032050
name: clathrin heavy chain binding
namespace: molecular_function
def: "Binding to a clathrin heavy chain." [GOC:mah]
is_a: GO:0030276 ! clathrin binding

[Term]
id: GO:0032051
name: clathrin light chain binding
namespace: molecular_function
def: "Binding to a clathrin light chain." [GOC:mah]
is_a: GO:0030276 ! clathrin binding

[Term]
id: GO:0032052
name: bile acid binding
namespace: molecular_function
def: "Binding to a bile acid, a steroid carboxylic acids occurring in bile." [GOC:rph]
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0032053
name: ciliary basal body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124]
synonym: "microtubule basal body organisation" BROAD [GOC:mah]
synonym: "microtubule basal body organization" BROAD []
synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031023 ! microtubule organizing center organization
is_a: GO:0044782 ! cilium organization

[Term]
id: GO:0032055
name: negative regulation of translation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation in response to stress" EXACT []
synonym: "down-regulation of translation in response to stress" EXACT []
synonym: "downregulation of translation in response to stress" EXACT []
synonym: "inhibition of translation in response to stress" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0032056
name: positive regulation of translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation in response to stress" NARROW []
synonym: "stimulation of translation in response to stress" NARROW []
synonym: "up regulation of translation in response to stress" EXACT []
synonym: "up-regulation of translation in response to stress" EXACT []
synonym: "upregulation of translation in response to stress" EXACT []
is_a: GO:0043555 ! regulation of translation in response to stress
is_a: GO:0045727 ! positive regulation of translation

[Term]
id: GO:0032057
name: negative regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation initiation in response to stress" EXACT []
synonym: "down-regulation of translation initiation in response to stress" EXACT []
synonym: "downregulation of translation initiation in response to stress" EXACT []
synonym: "inhibition of translation initiation in response to stress" NARROW []
is_a: GO:0045947 ! negative regulation of translational initiation
relationship: part_of GO:0006950 ! response to stress

[Term]
id: GO:0032058
name: positive regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation initiation in response to stress" NARROW []
synonym: "stimulation of translation initiation in response to stress" NARROW []
synonym: "up regulation of translation initiation in response to stress" EXACT []
synonym: "up-regulation of translation initiation in response to stress" EXACT []
synonym: "upregulation of translation initiation in response to stress" EXACT []
is_a: GO:0045948 ! positive regulation of translational initiation
relationship: part_of GO:0006950 ! response to stress

[Term]
id: GO:0032059
name: bleb
namespace: cellular_component
def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
subset: goslim_pir
synonym: "plasma membrane bleb" EXACT [GOC:pr]
xref: Wikipedia:Bleb_(cell_biology)
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0032060
name: bleb assembly
namespace: biological_process
def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
synonym: "blebbing" BROAD [GOC:pr]
synonym: "cell blebbing" EXACT []
synonym: "membrane blebbing" BROAD [GOC:pr]
synonym: "plasma membrane bleb assembly" EXACT [GOC:pr]
synonym: "plasma membrane blebbing" EXACT [GOC:pr]
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0032061
name: negative regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "down regulation of translation in response to osmotic stress" EXACT []
synonym: "down-regulation of translation in response to osmotic stress" EXACT []
synonym: "downregulation of translation in response to osmotic stress" EXACT []
synonym: "inhibition of translation in response to osmotic stress" NARROW []
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0043557 ! regulation of translation in response to osmotic stress

[Term]
id: GO:0032062
name: positive regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "activation of translation in response to osmotic stress" NARROW []
synonym: "stimulation of translation in response to osmotic stress" NARROW []
synonym: "up regulation of translation in response to osmotic stress" EXACT []
synonym: "up-regulation of translation in response to osmotic stress" EXACT []
synonym: "upregulation of translation in response to osmotic stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0043557 ! regulation of translation in response to osmotic stress

[Term]
id: GO:0032063
name: negative regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "down regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "downregulation of translation initiation in response to osmotic stress" EXACT []
synonym: "inhibition of translation initiation in response to osmotic stress" NARROW []
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress
is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress

[Term]
id: GO:0032064
name: positive regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "activation of translation initiation in response to osmotic stress" NARROW []
synonym: "stimulation of translation initiation in response to osmotic stress" NARROW []
synonym: "up regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "upregulation of translation initiation in response to osmotic stress" EXACT []
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress
is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress

[Term]
id: GO:0032065
name: maintenance of protein location in cell cortex
namespace: biological_process
def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw]
synonym: "cortical protein anchoring" RELATED []
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0032067
name: type IV site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995]
synonym: "type IV restriction enzyme activity" EXACT []
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity

[Term]
id: GO:0032068
name: type IV site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995]
synonym: "type IV restriction enzyme complex" EXACT []
is_a: GO:1905347 ! endodeoxyribonuclease complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0032069
name: regulation of nuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "nuclease regulator activity" RELATED []
is_a: GO:0051336 ! regulation of hydrolase activity
is_a: GO:0060255 ! regulation of macromolecule metabolic process

[Term]
id: GO:0032070
name: regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "deoxyribonuclease regulator" RELATED []
synonym: "DNase regulator" RELATED []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0051052 ! regulation of DNA metabolic process

[Term]
id: GO:0032071
name: regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "endodeoxyribonuclease regulator" RELATED []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity

[Term]
id: GO:0032072
name: regulation of restriction endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity

[Term]
id: GO:0032073
name: negative regulation of restriction endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW []
synonym: "restriction alleviation" NARROW []
synonym: "restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "restriction enzyme inhibitor" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity

[Term]
id: GO:0032074
name: negative regulation of nuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of nuclease activity" EXACT []
synonym: "down-regulation of nuclease activity" EXACT []
synonym: "downregulation of nuclease activity" EXACT []
synonym: "inhibition of nuclease activity" NARROW []
synonym: "nuclease inhibitor" RELATED []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0032075
name: positive regulation of nuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of nuclease activity" NARROW []
synonym: "nuclease activator" RELATED []
synonym: "stimulation of nuclease activity" NARROW []
synonym: "up regulation of nuclease activity" EXACT []
synonym: "up-regulation of nuclease activity" EXACT []
synonym: "upregulation of nuclease activity" EXACT []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0032076
name: negative regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "deoxyribonuclease inhibitor" RELATED []
synonym: "DNase inhibitor" RELATED []
synonym: "down regulation of deoxyribonuclease activity" EXACT []
synonym: "down-regulation of deoxyribonuclease activity" EXACT []
synonym: "downregulation of deoxyribonuclease activity" EXACT []
synonym: "inhibition of deoxyribonuclease activity" NARROW []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032074 ! negative regulation of nuclease activity
is_a: GO:0051053 ! negative regulation of DNA metabolic process

[Term]
id: GO:0032077
name: positive regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activator" RELATED []
synonym: "DNase activator" RELATED []
synonym: "stimulation of deoxyribonuclease activity" NARROW []
synonym: "up regulation of deoxyribonuclease activity" EXACT []
synonym: "up-regulation of deoxyribonuclease activity" EXACT []
synonym: "upregulation of deoxyribonuclease activity" EXACT []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0051054 ! positive regulation of DNA metabolic process

[Term]
id: GO:0032078
name: negative regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of endodeoxyribonuclease activity" EXACT []
synonym: "endodeoxyribonuclease inhibitor" RELATED []
synonym: "inhibition of endodeoxyribonuclease activity" NARROW []
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity

[Term]
id: GO:0032079
name: positive regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of endodeoxyribonuclease activity" NARROW []
synonym: "endodeoxyribonuclease activator" RELATED []
synonym: "stimulation of endodeoxyribonuclease activity" NARROW []
synonym: "up regulation of endodeoxyribonuclease activity" EXACT []
synonym: "up-regulation of endodeoxyribonuclease activity" EXACT []
synonym: "upregulation of endodeoxyribonuclease activity" EXACT []
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity

[Term]
id: GO:0032080
name: obsolete negative regulation of type I site-specific deoxyribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the rate of type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of type I restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "type I restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "type I restriction enzyme inhibitor" RELATED []
is_obsolete: true

[Term]
id: GO:0032081
name: obsolete negative regulation of type II site-specific deoxyribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of type II restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "type II restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "type II restriction enzyme inhibitor" RELATED []
is_obsolete: true

[Term]
id: GO:0032082
name: obsolete negative regulation of type III site-specific deoxyribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the rate of type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of type III restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "type III restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "type III restriction enzyme inhibitor" RELATED []
is_obsolete: true

[Term]
id: GO:0032083
name: obsolete negative regulation of type IV site-specific deoxyribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the rate of type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of type IV restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "type IV restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "type IV restriction enzyme inhibitor" RELATED []
is_obsolete: true

[Term]
id: GO:0032084
name: regulation of type I site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "type I restriction endodeoxyribonuclease regulator" RELATED []
synonym: "type I restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
is_a: GO:0043462 ! regulation of ATP-dependent activity

[Term]
id: GO:0032085
name: regulation of type II site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "type II restriction endodeoxyribonuclease regulator" RELATED []
synonym: "type II restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity

[Term]
id: GO:0032086
name: regulation of type III site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of type III restriction endoribonuclease activity" EXACT [GOC:dph]
synonym: "type III restriction endodeoxyribonuclease regulator" RELATED []
synonym: "type III restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity

[Term]
id: GO:0032087
name: regulation of type IV site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "type IV restriction endodeoxyribonuclease regulator" RELATED []
synonym: "type IV restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity

[Term]
id: GO:0032088
name: negative regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "NF-kappaB inhibitor" RELATED []
is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity

[Term]
id: GO:0032089
name: NACHT domain binding
namespace: molecular_function
def: "Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs." [GOC:rl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032090
name: Pyrin domain binding
namespace: molecular_function
def: "Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl]
synonym: "DAPIN domain binding" EXACT []
synonym: "PAAD domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032091
name: negative regulation of protein binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of protein binding" EXACT []
synonym: "down-regulation of protein binding" EXACT []
synonym: "downregulation of protein binding" EXACT []
synonym: "inhibition of protein binding" NARROW []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051100 ! negative regulation of binding

[Term]
id: GO:0032092
name: positive regulation of protein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of protein binding" NARROW []
synonym: "stimulation of protein binding" NARROW []
synonym: "up regulation of protein binding" EXACT []
synonym: "up-regulation of protein binding" EXACT []
synonym: "upregulation of protein binding" EXACT []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051099 ! positive regulation of binding

[Term]
id: GO:0032093
name: SAM domain binding
namespace: molecular_function
def: "Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230]
synonym: "Sterile Alpha Motif domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032094
name: response to food
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0032095
name: regulation of response to food
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add]
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: regulates GO:0032094 ! response to food

[Term]
id: GO:0032096
name: negative regulation of response to food
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add]
synonym: "down regulation of response to food" EXACT []
synonym: "down-regulation of response to food" EXACT []
synonym: "downregulation of response to food" EXACT []
synonym: "inhibition of response to food" NARROW []
is_a: GO:0032095 ! regulation of response to food
is_a: GO:0032108 ! negative regulation of response to nutrient levels
relationship: negatively_regulates GO:0032094 ! response to food

[Term]
id: GO:0032097
name: positive regulation of response to food
namespace: biological_process
def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add]
synonym: "activation of response to food" NARROW []
synonym: "stimulation of response to food" NARROW []
synonym: "up regulation of response to food" EXACT []
synonym: "up-regulation of response to food" EXACT []
synonym: "upregulation of response to food" EXACT []
is_a: GO:0032095 ! regulation of response to food
is_a: GO:0032109 ! positive regulation of response to nutrient levels
relationship: positively_regulates GO:0032094 ! response to food

[Term]
id: GO:0032098
name: regulation of appetite
namespace: biological_process
def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add]
synonym: "regulation of hunger" RELATED []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032099
name: negative regulation of appetite
namespace: biological_process
def: "Any process that reduces appetite." [GOC:add]
synonym: "appetite suppression" RELATED []
synonym: "down regulation of appetite" EXACT []
synonym: "down-regulation of appetite" EXACT []
synonym: "downregulation of appetite" EXACT []
synonym: "inhibition of appetite" NARROW []
synonym: "negative regulation of hunger" RELATED []
is_a: GO:0032096 ! negative regulation of response to food
is_a: GO:0032098 ! regulation of appetite

[Term]
id: GO:0032100
name: positive regulation of appetite
namespace: biological_process
def: "Any process that increases appetite." [GOC:add]
synonym: "activation of appetite" NARROW []
synonym: "appetite stimulation" RELATED []
synonym: "positive regulation of hunger" RELATED []
synonym: "stimulation of appetite" NARROW []
synonym: "up regulation of appetite" EXACT []
synonym: "up-regulation of appetite" EXACT []
synonym: "upregulation of appetite" EXACT []
is_a: GO:0032097 ! positive regulation of response to food
is_a: GO:0032098 ! regulation of appetite

[Term]
id: GO:0032101
name: regulation of response to external stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032102
name: negative regulation of response to external stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to external stimulus" EXACT []
synonym: "down-regulation of response to external stimulus" EXACT []
synonym: "downregulation of response to external stimulus" EXACT []
synonym: "inhibition of response to external stimulus" NARROW []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032103
name: positive regulation of response to external stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to external stimulus" NARROW []
synonym: "stimulation of response to external stimulus" NARROW []
synonym: "up regulation of response to external stimulus" EXACT []
synonym: "up-regulation of response to external stimulus" EXACT []
synonym: "upregulation of response to external stimulus" EXACT []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032104
name: obsolete regulation of response to extracellular stimulus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah]
comment: The reason for obsoletion is that this term is too vague.
is_obsolete: true
consider: GO:0048583

[Term]
id: GO:0032105
name: obsolete negative regulation of response to extracellular stimulus
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah]
comment: The reason for obsoletion is that this term is too vague.
synonym: "down regulation of response to extracellular stimulus" EXACT []
synonym: "down-regulation of response to extracellular stimulus" EXACT []
synonym: "downregulation of response to extracellular stimulus" EXACT []
synonym: "inhibition of response to extracellular stimulus" NARROW []
is_obsolete: true
consider: GO:0048585

[Term]
id: GO:0032106
name: obsolete positive regulation of response to extracellular stimulus
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah]
comment: The reason for obsoletion is that this term is too vague.
synonym: "activation of response to extracellular stimulus" NARROW []
synonym: "stimulation of response to extracellular stimulus" NARROW []
synonym: "up regulation of response to extracellular stimulus" EXACT []
synonym: "up-regulation of response to extracellular stimulus" EXACT []
synonym: "upregulation of response to extracellular stimulus" EXACT []
is_obsolete: true
consider: GO:0048584

[Term]
id: GO:0032107
name: regulation of response to nutrient levels
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032108
name: negative regulation of response to nutrient levels
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
synonym: "down regulation of response to nutrient levels" EXACT []
synonym: "down-regulation of response to nutrient levels" EXACT []
synonym: "downregulation of response to nutrient levels" EXACT []
synonym: "inhibition of response to nutrient levels" NARROW []
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032109
name: positive regulation of response to nutrient levels
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
synonym: "activation of response to nutrient levels" NARROW []
synonym: "stimulation of response to nutrient levels" NARROW []
synonym: "up regulation of response to nutrient levels" EXACT []
synonym: "up-regulation of response to nutrient levels" EXACT []
synonym: "upregulation of response to nutrient levels" EXACT []
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032110
name: regulation of protein histidine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0032111
name: obsolete activation of protein histidine kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein histidine kinase activator" RELATED []
is_obsolete: true
consider: GO:0030295

[Term]
id: GO:0032112
name: obsolete negative regulation of protein histidine kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of protein histidine kinase activity" EXACT []
synonym: "down-regulation of protein histidine kinase activity" EXACT []
synonym: "downregulation of protein histidine kinase activity" EXACT []
synonym: "inhibition of protein histidine kinase activity" NARROW []
synonym: "protein histidine kinase inhibitor" RELATED []
is_obsolete: true

[Term]
id: GO:0032113
name: regulation of carbohydrate phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0032114
name: obsolete regulation of glucose-6-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0032115
name: sorbose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucitol + NADP+ = L-sorbose + H+ + NADPH. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.1.289, RHEA:14609]
synonym: "D-glucitol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.289]
synonym: "Sou1p" RELATED [EC:1.1.1.289]
xref: EC:1.1.1.289
xref: KEGG_REACTION:R07346
xref: MetaCyc:1.1.1.289-RXN
xref: RHEA:14609
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032116
name: SMC loading complex
namespace: cellular_component
def: "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066]
synonym: "chromatin loading complex" RELATED []
synonym: "cohesin loading complex" NARROW []
synonym: "SCC2/SCC4 loading complex" NARROW []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032117
name: horsetail-astral microtubule array
namespace: cellular_component
def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942]
synonym: "HAA" EXACT []
is_a: GO:0005818 ! aster
relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton

[Term]
id: GO:0032118
name: horsetail-astral microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah]
synonym: "horsetail-astral microtubule array organization" EXACT []
synonym: "horsetail-astral microtubule organisation" EXACT [GOC:mah]
synonym: "horsetail-astral microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement

[Term]
id: GO:0032119
name: obsolete sequestering of zinc ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
is_obsolete: true
consider: GO:0140487

[Term]
id: GO:0032120
name: ascospore-type prospore membrane formation
namespace: biological_process
alt_id: GO:0099097
def: "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt, PMID:27630265]
synonym: "ascospore-type prospore membrane assembly" RELATED []
synonym: "forespore membrane biosynthesis" EXACT []
synonym: "forespore membrane formation" EXACT []
synonym: "FSM assembly" EXACT []
synonym: "FSM biosynthesis" EXACT []
synonym: "FSM formation" EXACT []
synonym: "prospore membrane biogenesis" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0071709 ! membrane assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0031321 ! ascospore-type prospore assembly

[Term]
id: GO:0032121
name: meiotic attachment of telomeric heterochromatin to spindle pole body
namespace: biological_process
def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation." [GOC:pr, PMID:16615890]
synonym: "attachment of telomeres to spindle pole body" BROAD []
synonym: "attachment of telomeric chromatin to spindle pole body" BROAD []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045141 ! meiotic telomere clustering

[Term]
id: GO:0032122
name: oral apparatus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830]
synonym: "oral apparatus morphogenesis" RELATED []
synonym: "oral apparatus organisation" EXACT [GOC:mah]
synonym: "oral apparatus organization and biogenesis" RELATED [GOC:mah]
synonym: "stomatogenesis" RELATED []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0032123
name: deep fiber
namespace: cellular_component
def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189]
synonym: "deep fibre" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0031912 ! oral apparatus

[Term]
id: GO:0032124
name: macronucleus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]
synonym: "macronuclear organization" EXACT []
synonym: "macronuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "macronucleus organisation" EXACT [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0032125
name: micronucleus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]
synonym: "micronuclear organization" EXACT []
synonym: "micronuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "micronucleus organisation" EXACT [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0032126
name: eisosome
namespace: cellular_component
def: "A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization." [GOC:al, GOC:vw, PMID:16496001, PMID:22368779]
xref: Wikipedia:Eisosome
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0032127
name: dense core granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense core granule." [GOC:mah]
synonym: "dense core vesicle membrane" EXACT [GOC:kmv]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031045 ! dense core granule

[Term]
id: GO:0032129
name: histone H3K9 deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [PMID:28450737]
synonym: "histone deacetylase activity (H3-K9 specific)" EXACT []
synonym: "histone H3-K9 deacetylase activity" EXACT []
synonym: "histone H3K9 deacetylase activity" BROAD []
is_a: GO:0141050 ! histone H3K deacetylase activity
is_a: GO:0141221 ! histone deacetylase activity, hydrolytic mechanism

[Term]
id: GO:0032130
name: medial membrane band assembly
namespace: biological_process
def: "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003]
synonym: "medial membrane band formation" RELATED [GOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:0032131
name: alkylated DNA binding
namespace: molecular_function
def: "Binding to an alkylated residue in DNA." [GOC:mah]
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:0032132
name: O6-alkylguanine-DNA binding
namespace: molecular_function
def: "Binding to an O6-alkylguanine adduct in DNA." [GOC:mah, PMID:16679453]
is_a: GO:0032131 ! alkylated DNA binding

[Term]
id: GO:0032133
name: chromosome passenger complex
namespace: cellular_component
def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
synonym: "chromosomal passenger complex" EXACT [GOC:mcc]
synonym: "CPC" BROAD [GOC:mah]
synonym: "CPC complex" EXACT [GOC:vw]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0032135
name: DNA insertion or deletion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing an insertion or a deletion." [GOC:vk]
synonym: "DNA insertion binding" NARROW []
synonym: "insertion binding" EXACT []
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032136
name: adenine/cytosine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing an A/C mispair." [GOC:vk]
synonym: "A/C mispair binding" EXACT [GOC:bf]
synonym: "C/A mispair binding" EXACT [GOC:bf]
synonym: "cytosine/adenine mispair binding" RELATED [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032137
name: guanine/thymine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a G/T mispair." [GOC:vk]
synonym: "G/T mispair binding" EXACT [GOC:bf]
synonym: "T/G mispair binding" EXACT [GOC:bf]
synonym: "thymine/guanine mispair binding" EXACT [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032138
name: single base insertion or deletion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a single base insertion or deletion." [GOC:vk]
synonym: "single base insertion binding" NARROW []
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0032139
name: dinucleotide insertion or deletion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion." [GOC:vk]
synonym: "dinucleotide insertion binding" NARROW []
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0032140
name: single adenine insertion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032141
name: single cytosine insertion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032142
name: single guanine insertion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032143
name: single thymine insertion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032144
name: 4-aminobutyrate transaminase complex
namespace: cellular_component
def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998]
synonym: "ABAT complex" EXACT []
synonym: "GABA transaminase complex" EXACT []
synonym: "GABA-T complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0032145
name: succinate-semialdehyde dehydrogenase binding
namespace: molecular_function
def: "Binding to succinate-semialdehyde dehydrogenase." [GOC:mah]
synonym: "succinic semialdehyde dehydrogenase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0032147
name: activation of protein kinase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "protein kinase activation" RELATED []
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0032148
name: activation of protein kinase B activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg]
subset: gocheck_obsoletion_candidate
synonym: "protein kinase B activation" EXACT []
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0032149
name: response to rhamnose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg]
synonym: "response to L-rhamnose stimulus" NARROW []
synonym: "response to rhamnose stimulus" EXACT [GOC:dos]
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:0032150
name: ubiquinone biosynthetic process from chorismate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0032151
name: mitotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032152
name: meiotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032153
name: cell division site
namespace: cellular_component
def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]
comment: Note that this term refers to the future site of division in a cell that has not yet divided.
subset: goslim_pir
synonym: "cell division plane" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0032154
name: cleavage furrow
namespace: cellular_component
def: "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409]
comment: While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists.
xref: Wikipedia:Cleavage_furrow
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0032155
name: obsolete cell division site part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "cell division plane part" EXACT []
is_obsolete: true
consider: GO:0032153

[Term]
id: GO:0032156
name: septin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0032157
name: prospore contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555]
synonym: "actomyosin ring" RELATED []
synonym: "cytokinetic ring" RELATED []
synonym: "meiotic contractile ring" RELATED []
is_a: GO:0110086 ! meiotic actomyosin contractile ring
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0032158
name: septin band
namespace: cellular_component
def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032159
name: septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0032160
name: septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244]
synonym: "septin bar" RELATED []
is_a: GO:0032156 ! septin cytoskeleton
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0032161
name: cleavage apparatus septin structure
namespace: cellular_component
def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0032153 ! cell division site
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032162
name: mating projection septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0032158 ! septin band
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0032163
name: hyphal septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0032158 ! septin band

[Term]
id: GO:0032164
name: hyphal septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap

[Term]
id: GO:0032165
name: prospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032166
name: chlamydospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032167
name: obsolete septin patch
namespace: cellular_component
def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555]
comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure.
synonym: "septin patch" EXACT []
is_obsolete: true

[Term]
id: GO:0032168
name: hyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032169
name: prospore septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0032170
name: pseudohyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032171
name: germ tube septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap
relationship: part_of GO:0032179 ! germ tube

[Term]
id: GO:0032172
name: germ tube septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244]
is_a: GO:0005940 ! septin ring
relationship: part_of GO:0032179 ! germ tube

[Term]
id: GO:0032173
name: septin collar
namespace: cellular_component
def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244]
synonym: "septin hourglass" EXACT [PMID:32386534]
is_a: GO:0032156 ! septin cytoskeleton
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0032174
name: cellular bud neck septin collar
namespace: cellular_component
def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032173 ! septin collar

[Term]
id: GO:0032175
name: mating projection septin ring
namespace: cellular_component
def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0032176
name: split septin rings
namespace: cellular_component
def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0032177
name: cellular bud neck split septin rings
namespace: cellular_component
def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032176 ! split septin rings

[Term]
id: GO:0032178
name: medial membrane band
namespace: cellular_component
def: "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003]
synonym: "sterol-rich membrane band" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0032179
name: germ tube
namespace: cellular_component
def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148]
subset: goslim_pir
xref: Wikipedia:Germ_tube
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0032180
name: ubiquinone biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032181
name: dinucleotide repeat insertion binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk]
is_a: GO:0032139 ! dinucleotide insertion or deletion binding

[Term]
id: GO:0032182
name: ubiquitin-like protein binding
namespace: molecular_function
def: "Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah]
subset: goslim_chembl
subset: goslim_yeast
synonym: "small conjugating protein binding" EXACT [GOC:dph]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032183
name: SUMO binding
namespace: molecular_function
def: "Binding to the small ubiquitin-like protein SUMO." [GOC:mah]
synonym: "Smt3 binding" RELATED []
synonym: "Smt3 monomer binding" NARROW []
is_a: GO:0032182 ! ubiquitin-like protein binding

[Term]
id: GO:0032184
name: SUMO polymer binding
namespace: molecular_function
def: "Binding to a polymer of the small ubiquitin-like protein SUMO." [GOC:mah]
synonym: "Smt3 polymer binding" EXACT []
is_a: GO:0032183 ! SUMO binding

[Term]
id: GO:0032185
name: septin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
synonym: "septin cytoskeleton organisation" EXACT [GOC:mah]
synonym: "septin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0032186
name: cellular bud neck septin ring organization
namespace: biological_process
def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah]
synonym: "cellular bud neck septin ring organisation" EXACT [GOC:mah]
is_a: GO:0031106 ! septin ring organization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000281 ! mitotic cytokinesis
relationship: part_of GO:0007105 ! cytokinesis, division site positioning

[Term]
id: GO:0032187
name: obsolete actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. The process in which a contractile ring is positioned or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah]
comment: The reason for obsoletion is that this represents a phenotype.
synonym: "contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
is_obsolete: true
replaced_by: GO:0007105

[Term]
id: GO:0032188
name: obsolete establishment of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis." [GOC:mah]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
synonym: "actomyosin ring positioning" RELATED [GOC:mah]
synonym: "contractile ring positioning" BROAD [GOC:mah]
synonym: "cytokinesis site selection by contractile ring positioning" EXACT [GOC:mah, GOC:vw]
synonym: "establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0007105

[Term]
id: GO:0032189
name: obsolete maintenance of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah]
comment: The reason for obsoletion is that this represents a phenotype.
synonym: "cytokinetic ring anchoring" RELATED []
synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0032190
name: acrosin binding
namespace: molecular_function
alt_id: GO:0032191
alt_id: GO:0032192
def: "Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221]
synonym: "acrosin heavy chain binding" NARROW []
synonym: "acrosin light chain binding" NARROW []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0032193
name: ubiquinone biosynthetic process via 2-polyprenylphenol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032194
name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032195
name: post-lysosomal vacuole
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:23494323, PMID:9276759, PMID:9394012]
synonym: "post-lysosome" EXACT [GOC:dph]
synonym: "postlysosome" EXACT []
is_a: GO:0005773 ! vacuole
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0032196
name: transposition
namespace: biological_process
def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site." [ISBN:1555812090, PMID:14682279, PMID:25893143]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_pir
subset: goslim_yeast
xref: Wikipedia:Transposon
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0032197
name: retrotransposition
namespace: biological_process
alt_id: GO:0006319
alt_id: GO:0006320
alt_id: GO:0006321
alt_id: GO:0006322
def: "A type of transposition in which a transposable element (transposon) copies and pastes itself into a different genomic location by transcription and convertsion of the transcribed RNA back into DNA through reverse transcription." [ISBN:1555812090, PMID:26912865, PMID:30416149, PMID:30958115, PMID:32588192]
synonym: "Class I transposition" EXACT []
synonym: "retrotransposon transposition" EXACT []
synonym: "RNA-mediated transposition" EXACT [GOC:dph, GOC:tb]
synonym: "Tf transposition" NARROW []
synonym: "transposition via RNA intermediate" EXACT []
synonym: "transposition, RNA-mediated" EXACT []
synonym: "Ty element transposition" NARROW []
synonym: "Ty1 element transposition" NARROW []
synonym: "Ty2 element transposition" NARROW []
synonym: "Ty3 element transposition" NARROW []
xref: Wikipedia:Transposon##Class_I\:_Retrotransposons
is_a: GO:0032196 ! transposition

[Term]
id: GO:0032198
name: obsolete MITE transposition
namespace: biological_process
def: "OBSOLETE. Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
replaced_by: GO:0006313

[Term]
id: GO:0032199
name: obsolete reverse transcription involved in RNA-mediated transposition
namespace: biological_process
def: "OBSOLETE. The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, GOC:txnOH, ISBN:1555812090]
comment: This term was obsoleted because it represents a molecular function.
synonym: "reverse transcription during retrotransposition" EXACT []
is_obsolete: true
replaced_by: GO:0032197

[Term]
id: GO:0032200
name: telomere organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "chromosome organization, telomeric" EXACT []
synonym: "organization of chromosome, telomeric region" EXACT []
synonym: "telomere organisation" EXACT [GOC:mah]
synonym: "telomere organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0032201
name: telomere maintenance via semi-conservative replication
namespace: biological_process
def: "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication." [GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:vw, PMID:16598261]
synonym: "equal telomere replication" RELATED []
synonym: "telomeric fork progression" NARROW []
synonym: "telomeric replication fork progression" NARROW []
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0032202
name: telomere assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins." [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671]
synonym: "telomere formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032200 ! telomere organization

[Term]
id: GO:0032203
name: telomere formation via telomerase
namespace: biological_process
def: "A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme." [GOC:cjm, GOC:ns, PMID:11902675, PMID:8622671]
is_a: GO:0032202 ! telomere assembly

[Term]
id: GO:0032204
name: regulation of telomere maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032205
name: negative regulation of telomere maintenance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
synonym: "down regulation of telomere maintenance" EXACT []
synonym: "down-regulation of telomere maintenance" EXACT []
synonym: "downregulation of telomere maintenance" EXACT []
synonym: "inhibition of telomere maintenance" NARROW []
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032206
name: positive regulation of telomere maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
synonym: "activation of telomere maintenance" NARROW []
synonym: "stimulation of telomere maintenance" NARROW []
synonym: "up regulation of telomere maintenance" EXACT []
synonym: "up-regulation of telomere maintenance" EXACT []
synonym: "upregulation of telomere maintenance" EXACT []
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032207
name: regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0072695 ! regulation of DNA recombination at telomere
relationship: regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032208
name: negative regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
synonym: "down regulation of telomere maintenance via recombination" EXACT []
synonym: "down-regulation of telomere maintenance via recombination" EXACT []
synonym: "downregulation of telomere maintenance via recombination" EXACT []
synonym: "inhibition of telomere maintenance via recombination" NARROW []
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:0032207 ! regulation of telomere maintenance via recombination
is_a: GO:0045950 ! negative regulation of mitotic recombination
is_a: GO:0048239 ! negative regulation of DNA recombination at telomere
relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032209
name: positive regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
synonym: "activation of telomere maintenance via recombination" NARROW []
synonym: "stimulation of telomere maintenance via recombination" NARROW []
synonym: "up regulation of telomere maintenance via recombination" EXACT []
synonym: "up-regulation of telomere maintenance via recombination" EXACT []
synonym: "upregulation of telomere maintenance via recombination" EXACT []
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0032207 ! regulation of telomere maintenance via recombination
is_a: GO:0045951 ! positive regulation of mitotic recombination
is_a: GO:0072696 ! positive regulation of DNA recombination at telomere
relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032210
name: regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening
is_a: GO:2000278 ! regulation of DNA biosynthetic process
relationship: regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032211
name: negative regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
synonym: "down regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "downregulation of telomere maintenance via telomerase activity" EXACT []
synonym: "inhibition of telomere maintenance via telomerase" NARROW []
is_a: GO:0032210 ! regulation of telomere maintenance via telomerase
is_a: GO:1904357 ! negative regulation of telomere maintenance via telomere lengthening
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032212
name: positive regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
synonym: "activation of telomere maintenance via telomerase" NARROW []
synonym: "stimulation of telomere maintenance via telomerase" NARROW []
synonym: "up regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "upregulation of telomere maintenance via telomerase activity" EXACT []
is_a: GO:0032210 ! regulation of telomere maintenance via telomerase
is_a: GO:1904358 ! positive regulation of telomere maintenance via telomere lengthening
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032213
name: regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032214
name: negative regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication
relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032215
name: positive regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
synonym: "activation of telomere maintenance via semi-conservative replication" NARROW []
synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW []
synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT []
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032216
name: glucosaminyl-phosphatidylinositol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA." [PMID:29484956]
synonym: "glucosaminyl-phosphotidylinositol O-acyltransferase activity" EXACT []
synonym: "GPI-inositol acyltransferase" RELATED []
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0032217
name: riboflavin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
synonym: "riboflavin transporter activity" RELATED []
xref: Reactome:R-HSA-3165230 "SLC52A1,2,3 transport RIB from extracellular region to cytosol"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0032218
name: riboflavin transport
namespace: biological_process
def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0032219
name: cell wall macromolecule catabolic process involved in cytogamy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy." [GOC:mah]
synonym: "cell wall macromolecule catabolic process during cytogamy" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016998 ! cell wall macromolecule catabolic process
relationship: part_of GO:0000755 ! cytogamy

[Term]
id: GO:0032220
name: plasma membrane fusion involved in cytogamy
namespace: biological_process
alt_id: GO:0070872
def: "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy." [GOC:mah, PMID:29134248]
synonym: "plasma membrane fusion during cytogamy" RELATED [GOC:dph, GOC:tb]
synonym: "plasma membrane organization involved in conjugation with cellular fusion" EXACT []
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0000755 ! cytogamy

[Term]
id: GO:0032221
name: Rpd3S complex
namespace: cellular_component
alt_id: GO:0000509
def: "A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151]
synonym: "Clr6 histone deacetylase complex II" EXACT []
synonym: "Clr6 histone deacetylase complex II'" EXACT [GOC:vw]
synonym: "Clr6-CII complex" EXACT []
synonym: "Clr6S complex" EXACT [PMID:19040720]
synonym: "Rpd3C(S)" EXACT []
synonym: "Rpd3S" EXACT []
synonym: "Sin3S" EXACT [PMID:25960410, PMID:37076472]
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0032222
name: regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032223
name: negative regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "down regulation of synaptic transmission, cholinergic" EXACT []
synonym: "down-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "downregulation of synaptic transmission, cholinergic" EXACT []
synonym: "inhibition of synaptic transmission, cholinergic" NARROW []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032224
name: positive regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "activation of synaptic transmission, cholinergic" NARROW []
synonym: "stimulation of synaptic transmission, cholinergic" NARROW []
synonym: "up regulation of synaptic transmission, cholinergic" EXACT []
synonym: "up-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "upregulation of synaptic transmission, cholinergic" EXACT []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032225
name: regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032226
name: positive regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "activation of synaptic transmission, dopaminergic" NARROW []
synonym: "stimulation of synaptic transmission, dopaminergic" NARROW []
synonym: "up regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "upregulation of synaptic transmission, dopaminergic" EXACT []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032227
name: negative regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "down regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "downregulation of synaptic transmission, dopaminergic" EXACT []
synonym: "inhibition of synaptic transmission, dopaminergic" NARROW []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032228
name: regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032229
name: negative regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "down regulation of synaptic transmission, GABAergic" EXACT []
synonym: "down-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "downregulation of synaptic transmission, GABAergic" EXACT []
synonym: "inhibition of synaptic transmission, GABAergic" NARROW []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032230
name: positive regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "activation of synaptic transmission, GABAergic" NARROW []
synonym: "stimulation of synaptic transmission, GABAergic" NARROW []
synonym: "up regulation of synaptic transmission, GABAergic" EXACT []
synonym: "up-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "upregulation of synaptic transmission, GABAergic" EXACT []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032231
name: regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0110053 ! regulation of actin filament organization
relationship: regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032232
name: negative regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "down regulation of actin filament bundle formation" EXACT []
synonym: "down-regulation of actin filament bundle formation" EXACT []
synonym: "downregulation of actin filament bundle formation" EXACT []
synonym: "inhibition of actin filament bundle formation" NARROW []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032233
name: positive regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "activation of actin filament bundle formation" NARROW []
synonym: "stimulation of actin filament bundle formation" NARROW []
synonym: "up regulation of actin filament bundle formation" EXACT []
synonym: "up-regulation of actin filament bundle formation" EXACT []
synonym: "upregulation of actin filament bundle formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032234
name: obsolete regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "regulation of calcium ion transport via store-operated calcium channel activity" EXACT []
synonym: "regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "regulation of store-operated calcium channel activity" EXACT []
is_obsolete: true
consider: GO:0015279

[Term]
id: GO:0032235
name: obsolete negative regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "negative regulation of calcium ion transport via store-operated calcium channel activity" EXACT []
synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "negative regulation of store-operated calcium channel activity" EXACT []
is_obsolete: true
consider: GO:0015279

[Term]
id: GO:0032236
name: obsolete positive regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "positive regulation of calcium ion transport via store-operated calcium channel activity" EXACT []
synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "positive regulation of store-operated calcium channel activity" EXACT []
synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT []
is_obsolete: true
consider: GO:0015279

[Term]
id: GO:0032237
name: activation of store-operated calcium channel activity
namespace: biological_process
def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:1901341 ! positive regulation of store-operated calcium channel activity

[Term]
id: GO:0032238
name: adenosine transport
namespace: biological_process
def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0032239
name: regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032240
name: negative regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032241
name: positive regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032242
name: regulation of nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
relationship: regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032243
name: negative regulation of nucleoside transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleoside transport" EXACT []
synonym: "down-regulation of nucleoside transport" EXACT []
synonym: "downregulation of nucleoside transport" EXACT []
synonym: "inhibition of nucleoside transport" NARROW []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0032242 ! regulation of nucleoside transport
relationship: negatively_regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032244
name: positive regulation of nucleoside transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleoside transport" NARROW []
synonym: "stimulation of nucleoside transport" NARROW []
synonym: "up regulation of nucleoside transport" EXACT []
synonym: "up-regulation of nucleoside transport" EXACT []
synonym: "upregulation of nucleoside transport" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0032242 ! regulation of nucleoside transport
relationship: positively_regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032245
name: regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032242 ! regulation of nucleoside transport

[Term]
id: GO:0032246
name: regulation of pyrimidine nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032242 ! regulation of nucleoside transport
relationship: regulates GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0032247
name: negative regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of purine nucleoside transport" EXACT []
synonym: "down-regulation of purine nucleoside transport" EXACT []
synonym: "downregulation of purine nucleoside transport" EXACT []
synonym: "inhibition of purine nucleoside transport" NARROW []
is_a: GO:0032243 ! negative regulation of nucleoside transport
is_a: GO:0032245 ! regulation of purine nucleoside transport

[Term]
id: GO:0032248
name: positive regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of purine nucleoside transport" NARROW []
synonym: "stimulation of purine nucleoside transport" NARROW []
synonym: "up regulation of purine nucleoside transport" EXACT []
synonym: "up-regulation of purine nucleoside transport" EXACT []
synonym: "upregulation of purine nucleoside transport" EXACT []
is_a: GO:0032244 ! positive regulation of nucleoside transport
is_a: GO:0032245 ! regulation of purine nucleoside transport

[Term]
id: GO:0032249
name: regulation of adenosine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032245 ! regulation of purine nucleoside transport
relationship: regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032250
name: negative regulation of adenosine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of adenosine transport" EXACT []
synonym: "down-regulation of adenosine transport" EXACT []
synonym: "downregulation of adenosine transport" EXACT []
synonym: "inhibition of adenosine transport" NARROW []
is_a: GO:0032247 ! negative regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
relationship: negatively_regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032251
name: positive regulation of adenosine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of adenosine transport" NARROW []
synonym: "stimulation of adenosine transport" NARROW []
synonym: "up regulation of adenosine transport" EXACT []
synonym: "up-regulation of adenosine transport" EXACT []
synonym: "upregulation of adenosine transport" EXACT []
is_a: GO:0032248 ! positive regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
relationship: positively_regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032252
name: secretory granule localization
namespace: biological_process
def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "secretory granule clustering" RELATED []
synonym: "secretory granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization

[Term]
id: GO:0032253
name: dense core granule localization
namespace: biological_process
def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "dense core granule clustering" RELATED []
synonym: "dense core granule localisation" EXACT [GOC:mah]
synonym: "dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032252 ! secretory granule localization

[Term]
id: GO:0032254
name: establishment of secretory granule localization
namespace: biological_process
def: "The directed movement of a secretory granule to a specific location." [GOC:mah]
synonym: "establishment of secretory granule localisation" EXACT [GOC:mah]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0032252 ! secretory granule localization

[Term]
id: GO:0032255
name: maintenance of secretory granule location
namespace: biological_process
def: "Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051655 ! maintenance of vesicle location
relationship: part_of GO:0032252 ! secretory granule localization

[Term]
id: GO:0032256
name: establishment of dense core granule localization
namespace: biological_process
def: "The directed movement of a dense core granule to a specific location." [GOC:mah]
synonym: "establishment of dense core granule localisation" EXACT [GOC:mah]
synonym: "establishment of dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032254 ! establishment of secretory granule localization
relationship: part_of GO:0032253 ! dense core granule localization

[Term]
id: GO:0032257
name: maintenance of dense core granule location
namespace: biological_process
def: "Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of dense core vesicle location" EXACT [GOC:kmv]
is_a: GO:0032255 ! maintenance of secretory granule location
relationship: part_of GO:0032253 ! dense core granule localization

[Term]
id: GO:0032258
name: cytoplasm to vacuole targeting by the Cvt pathway
namespace: biological_process
def: "A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643]
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:0061919 ! process utilizing autophagic mechanism

[Term]
id: GO:0032259
name: methylation
namespace: biological_process
def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah]
subset: goslim_chembl
xref: Wikipedia:Methylation
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0032260
name: response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah]
synonym: "response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009753 ! response to jasmonic acid
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0032261
name: purine nucleotide salvage
namespace: biological_process
def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp]
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0043101 ! purine-containing compound salvage
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0032262
name: pyrimidine nucleotide salvage
namespace: biological_process
def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0032263
name: GMP salvage
namespace: biological_process
def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006177 ! GMP biosynthetic process
is_a: GO:0106380 ! purine ribonucleotide salvage

[Term]
id: GO:0032264
name: IMP salvage
namespace: biological_process
def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006188 ! IMP biosynthetic process
is_a: GO:0106380 ! purine ribonucleotide salvage

[Term]
id: GO:0032265
name: XMP salvage
namespace: biological_process
def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0097293 ! XMP biosynthetic process
is_a: GO:0106380 ! purine ribonucleotide salvage

[Term]
id: GO:0032266
name: phosphatidylinositol-3-phosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]
synonym: "phosphatidylinositol 3-phosphate binding" EXACT []
synonym: "PtdIns-3-P binding" EXACT []
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0032267
name: tRNA(Ile)-lysidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H+ + lysidine(34) in tRNA(Ile2). This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414, RHEA:43744]
synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT []
synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT []
xref: EC:6.3.4.19
xref: RHEA:43744
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0032271
name: regulation of protein polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "regulation of protein polymerisation" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032272
name: negative regulation of protein polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "down regulation of protein polymerization" EXACT []
synonym: "down-regulation of protein polymerization" EXACT []
synonym: "downregulation of protein polymerization" EXACT []
synonym: "inhibition of protein polymerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
relationship: negatively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032273
name: positive regulation of protein polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "activation of protein polymerization" NARROW []
synonym: "stimulation of protein polymerization" NARROW []
synonym: "up regulation of protein polymerization" EXACT []
synonym: "up-regulation of protein polymerization" EXACT []
synonym: "upregulation of protein polymerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
relationship: positively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032274
name: gonadotropin secretion
namespace: biological_process
def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544]
synonym: "gonadotrophin secretion" EXACT []
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032275
name: luteinizing hormone secretion
namespace: biological_process
def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732]
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032276
name: regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "regulation of gonadotrophin secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032277
name: negative regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "down regulation of gonadotropin secretion" EXACT []
synonym: "down-regulation of gonadotropin secretion" EXACT []
synonym: "downregulation of gonadotropin secretion" EXACT []
synonym: "inhibition of gonadotropin secretion" NARROW []
synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph]
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032278
name: positive regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "activation of gonadotropin secretion" NARROW []
synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph]
synonym: "stimulation of gonadotropin secretion" NARROW []
synonym: "up regulation of gonadotropin secretion" EXACT []
synonym: "up-regulation of gonadotropin secretion" EXACT []
synonym: "upregulation of gonadotropin secretion" EXACT []
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032279
name: asymmetric synapse
namespace: cellular_component
def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef]
synonym: "Gray's type I synapse" EXACT []
is_a: GO:0098984 ! neuron to neuron synapse

[Term]
id: GO:0032280
name: symmetric synapse
namespace: cellular_component
def: "A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typically inhibitory." [GOC:dgh, GOC:ef]
comment: The term 'symmetric' in this name refers only to gross morphology. There is no implication of functional symmetry.
synonym: "Gray's type II synapse" EXACT []
is_a: GO:0098984 ! neuron to neuron synapse

[Term]
id: GO:0032281
name: AMPA glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef]
synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex" EXACT []
synonym: "AMPA receptor" RELATED []
synonym: "AMPA-selective glutamate receptor complex" EXACT []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0032282
name: plastid acetyl-CoA carboxylase complex
namespace: cellular_component
def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah]
synonym: "plastid ACCase complex" EXACT []
is_a: GO:0009317 ! acetyl-CoA carboxylase complex
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0032283
name: plastid acetate CoA-transferase complex
namespace: cellular_component
def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah]
is_a: GO:0009329 ! acetate CoA-transferase complex
relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex

[Term]
id: GO:0032284
name: obsolete plastid biotin carboxylase complex
namespace: cellular_component
def: "OBSOLETE. A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah]
comment: This term was obsoleted because it represents a homomer.
is_obsolete: true

[Term]
id: GO:0032285
name: non-myelinated axon ensheathment
namespace: biological_process
def: "The process in which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh]
synonym: "ensheathment of non-myelinated axons" EXACT []
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032286
name: central nervous system myelin maintenance
namespace: biological_process
def: "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh]
synonym: "central nervous system myelin sheath maintenance" EXACT []
synonym: "myelin maintenance in central nervous system" EXACT []
is_a: GO:0043217 ! myelin maintenance
relationship: part_of GO:0022010 ! central nervous system myelination

[Term]
id: GO:0032287
name: peripheral nervous system myelin maintenance
namespace: biological_process
def: "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh]
synonym: "myelin maintenance in peripheral nervous system" EXACT []
synonym: "peripheral nervous system myelin sheath maintenance" EXACT []
is_a: GO:0043217 ! myelin maintenance
relationship: part_of GO:0022011 ! myelination in peripheral nervous system

[Term]
id: GO:0032288
name: myelin assembly
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "myelin formation" RELATED [GOC:dph, GOC:tb]
synonym: "myelin sheath assembly" EXACT []
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0042552 ! myelination

[Term]
id: GO:0032289
name: central nervous system myelin formation
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh]
synonym: "central nervous system myelin sheath formation" EXACT []
synonym: "myelin formation in central nervous system" EXACT []
is_a: GO:0032288 ! myelin assembly
relationship: part_of GO:0022010 ! central nervous system myelination

[Term]
id: GO:0032290
name: peripheral nervous system myelin formation
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system." [GOC:dgh]
synonym: "myelin formation in peripheral nervous system" EXACT []
synonym: "peripheral nervous system myelin sheath formation" EXACT []
is_a: GO:0032288 ! myelin assembly
relationship: part_of GO:0022011 ! myelination in peripheral nervous system

[Term]
id: GO:0032291
name: axon ensheathment in central nervous system
namespace: biological_process
def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
synonym: "ensheathment of axons in central nervous system" EXACT []
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032292
name: peripheral nervous system axon ensheathment
namespace: biological_process
def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
synonym: "ensheathment of axons in peripheral nervous system" EXACT []
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032293
name: non-myelinated axon ensheathment in central nervous system
namespace: biological_process
def: "The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh]
synonym: "ensheathment of non-myelinated axons in central nervous system" EXACT []
is_a: GO:0032285 ! non-myelinated axon ensheathment
is_a: GO:0032291 ! axon ensheathment in central nervous system

[Term]
id: GO:0032294
name: peripheral nervous system non-myelinated axon ensheathment
namespace: biological_process
def: "The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh]
synonym: "ensheathment of non-myelinated axons in peripheral nervous system" EXACT []
is_a: GO:0032285 ! non-myelinated axon ensheathment
is_a: GO:0032292 ! peripheral nervous system axon ensheathment

[Term]
id: GO:0032295
name: ensheathment of neuronal cell bodies
namespace: biological_process
def: "The process in which satellite glial cells isolate neuronal cell bodies." [GOC:dgh]
is_a: GO:0007272 ! ensheathment of neurons

[Term]
id: GO:0032296
name: double-stranded RNA-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah]
synonym: "double-stranded RNA-specific RNase activity" EXACT []
synonym: "dsRNA-specific ribonuclease activity" EXACT []
synonym: "dsRNA-specific RNase activity" EXACT []
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0032297
name: negative regulation of DNA-templated DNA replication initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah]
synonym: "down regulation of DNA replication initiation" EXACT []
synonym: "down-regulation of DNA replication initiation" EXACT []
synonym: "downregulation of DNA replication initiation" EXACT []
synonym: "inhibition of DNA replication initiation" NARROW []
synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw]
synonym: "negative regulation of DNA-dependent DNA replication initiation" EXACT []
is_a: GO:0030174 ! regulation of DNA-templated DNA replication initiation
is_a: GO:2000104 ! negative regulation of DNA-templated DNA replication
relationship: negatively_regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0032298
name: positive regulation of DNA-templated DNA replication initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah]
synonym: "activation of DNA replication initiation" NARROW []
synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw]
synonym: "positive regulation of DNA-dependent DNA replication initiation" EXACT []
synonym: "stimulation of DNA replication initiation" NARROW []
synonym: "up regulation of DNA replication initiation" EXACT []
synonym: "up-regulation of DNA replication initiation" EXACT []
synonym: "upregulation of DNA replication initiation" EXACT []
is_a: GO:0030174 ! regulation of DNA-templated DNA replication initiation
is_a: GO:2000105 ! positive regulation of DNA-templated DNA replication
relationship: positively_regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0032299
name: ribonuclease H2 complex
namespace: cellular_component
def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815]
synonym: "RNase H2 complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0032300
name: mismatch repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0032301
name: MutSalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803]
synonym: "MMR complex" BROAD []
synonym: "MSH2/MSH6 complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032302
name: MutSbeta complex
namespace: cellular_component
def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803]
synonym: "MMR complex" BROAD []
synonym: "MSH2/MSH3 complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032303
name: regulation of icosanoid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah]
synonym: "regulation of eicosanoid secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:2000191 ! regulation of fatty acid transport
relationship: regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032304
name: negative regulation of icosanoid secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah]
synonym: "down regulation of icosanoid secretion" EXACT []
synonym: "down-regulation of icosanoid secretion" EXACT []
synonym: "downregulation of icosanoid secretion" EXACT []
synonym: "inhibition of icosanoid secretion" NARROW []
synonym: "negative regulation of eicosanoid secretion" EXACT []
is_a: GO:0032303 ! regulation of icosanoid secretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:2000192 ! negative regulation of fatty acid transport
relationship: negatively_regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032305
name: positive regulation of icosanoid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah]
synonym: "activation of icosanoid secretion" NARROW []
synonym: "positive regulation of eicosanoid secretion" EXACT []
synonym: "stimulation of icosanoid secretion" NARROW []
synonym: "up regulation of icosanoid secretion" EXACT []
synonym: "up-regulation of icosanoid secretion" EXACT []
synonym: "upregulation of icosanoid secretion" EXACT []
is_a: GO:0032303 ! regulation of icosanoid secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:2000193 ! positive regulation of fatty acid transport
relationship: positively_regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032306
name: regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah]
synonym: "regulation of prostacyclin secretion" NARROW []
is_a: GO:0032303 ! regulation of icosanoid secretion
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032307
name: negative regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah]
synonym: "down regulation of prostaglandin secretion" EXACT []
synonym: "down-regulation of prostaglandin secretion" EXACT []
synonym: "downregulation of prostaglandin secretion" EXACT []
synonym: "inhibition of prostaglandin secretion" NARROW []
synonym: "negative regulation of prostacyclin secretion" NARROW []
is_a: GO:0032304 ! negative regulation of icosanoid secretion
is_a: GO:0032306 ! regulation of prostaglandin secretion
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032308
name: positive regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah]
synonym: "activation of prostaglandin secretion" NARROW []
synonym: "positive regulation of prostacyclin secretion" NARROW []
synonym: "stimulation of prostaglandin secretion" NARROW []
synonym: "up regulation of prostaglandin secretion" EXACT []
synonym: "up-regulation of prostaglandin secretion" EXACT []
synonym: "upregulation of prostaglandin secretion" EXACT []
is_a: GO:0032305 ! positive regulation of icosanoid secretion
is_a: GO:0032306 ! regulation of prostaglandin secretion
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032309
name: icosanoid secretion
namespace: biological_process
def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue." [GOC:mah]
synonym: "eicosanoid secretion" EXACT []
is_a: GO:0046903 ! secretion
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:0032310
name: prostaglandin secretion
namespace: biological_process
def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue." [GOC:mah]
synonym: "prostacyclin secretion" NARROW []
is_a: GO:0015732 ! prostaglandin transport
is_a: GO:0023061 ! signal release
is_a: GO:0032309 ! icosanoid secretion
is_a: GO:0140353 ! lipid export from cell

[Term]
id: GO:0032311
name: angiogenin-PRI complex
namespace: cellular_component
def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787]
synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0032322
name: ubiquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
synonym: "ubiquinone breakdown" EXACT []
synonym: "ubiquinone catabolism" EXACT []
synonym: "ubiquinone degradation" EXACT []
is_a: GO:0006743 ! ubiquinone metabolic process
is_a: GO:1901662 ! quinone catabolic process

[Term]
id: GO:0032323
name: lipoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipoate." [GOC:mah]
synonym: "lipoic acid breakdown" EXACT []
synonym: "lipoic acid catabolism" EXACT []
synonym: "lipoic acid degradation" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0009106 ! lipoate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0032324
name: molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]
synonym: "molybdopterin cofactor anabolism" EXACT []
synonym: "molybdopterin cofactor biosynthesis" RELATED []
synonym: "molybdopterin cofactor formation" RELATED []
synonym: "molybdopterin cofactor synthesis" EXACT []
xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0032325
name: molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0032326
name: Mo-molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah]
synonym: "Mo-molybdopterin cofactor breakdown" EXACT []
synonym: "Mo-molybdopterin cofactor catabolism" EXACT []
synonym: "Mo-molybdopterin cofactor degradation" EXACT []
synonym: "Moco catabolic process" BROAD []
synonym: "Moco catabolism" BROAD []
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
is_a: GO:0032325 ! molybdopterin cofactor catabolic process

[Term]
id: GO:0032327
name: W-molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah]
synonym: "Moco catabolic process" BROAD []
synonym: "Moco catabolism" BROAD []
synonym: "W-molybdopterin cofactor breakdown" EXACT []
synonym: "W-molybdopterin cofactor catabolism" EXACT []
synonym: "W-molybdopterin cofactor degradation" EXACT []
is_a: GO:0032325 ! molybdopterin cofactor catabolic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process

[Term]
id: GO:0032328
name: alanine transport
namespace: biological_process
def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0032329
name: serine transport
namespace: biological_process
alt_id: GO:0090478
def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "serine import" NARROW []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0032330
name: regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0061035 ! regulation of cartilage development
relationship: regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032331
name: negative regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "down regulation of chondrocyte differentiation" EXACT []
synonym: "down-regulation of chondrocyte differentiation" EXACT []
synonym: "downregulation of chondrocyte differentiation" EXACT []
synonym: "inhibition of chondrocyte differentiation" NARROW []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0061037 ! negative regulation of cartilage development
relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032332
name: positive regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "activation of chondrocyte differentiation" NARROW []
synonym: "stimulation of chondrocyte differentiation" NARROW []
synonym: "up regulation of chondrocyte differentiation" EXACT []
synonym: "up-regulation of chondrocyte differentiation" EXACT []
synonym: "upregulation of chondrocyte differentiation" EXACT []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0061036 ! positive regulation of cartilage development
relationship: positively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032333
name: activin secretion
namespace: biological_process
def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah]
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0032334
name: inhibin secretion
namespace: biological_process
def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032335
name: regulation of activin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah]
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032336
name: negative regulation of activin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah]
synonym: "down regulation of activin secretion" EXACT []
synonym: "down-regulation of activin secretion" EXACT []
synonym: "downregulation of activin secretion" EXACT []
synonym: "inhibition of activin secretion" NARROW []
is_a: GO:0032335 ! regulation of activin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
relationship: negatively_regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032337
name: positive regulation of activin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah]
synonym: "activation of activin secretion" NARROW []
synonym: "stimulation of activin secretion" NARROW []
synonym: "up regulation of activin secretion" EXACT []
synonym: "up-regulation of activin secretion" EXACT []
synonym: "upregulation of activin secretion" EXACT []
is_a: GO:0032335 ! regulation of activin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032338
name: regulation of inhibin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032339
name: negative regulation of inhibin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah]
synonym: "down regulation of inhibin secretion" EXACT []
synonym: "down-regulation of inhibin secretion" EXACT []
synonym: "downregulation of inhibin secretion" EXACT []
synonym: "inhibition of inhibin secretion" NARROW []
is_a: GO:0032338 ! regulation of inhibin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032340
name: positive regulation of inhibin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah]
synonym: "activation of inhibin secretion" NARROW []
synonym: "stimulation of inhibin secretion" NARROW []
synonym: "up regulation of inhibin secretion" EXACT []
synonym: "up-regulation of inhibin secretion" EXACT []
synonym: "upregulation of inhibin secretion" EXACT []
is_a: GO:0032338 ! regulation of inhibin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032341
name: aldosterone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
synonym: "aldosterone metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0032342
name: aldosterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
is_a: GO:0006700 ! C21-steroid hormone biosynthetic process
is_a: GO:0006705 ! mineralocorticoid biosynthetic process
is_a: GO:0032341 ! aldosterone metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process

[Term]
id: GO:0032343
name: aldosterone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
is_a: GO:0006712 ! mineralocorticoid catabolic process
is_a: GO:0008208 ! C21-steroid hormone catabolic process
is_a: GO:0032341 ! aldosterone metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0032344
name: regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "regulation of aldosterone metabolism" EXACT []
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032345
name: negative regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "down regulation of aldosterone metabolic process" EXACT []
synonym: "down-regulation of aldosterone metabolic process" EXACT []
synonym: "downregulation of aldosterone metabolic process" EXACT []
synonym: "inhibition of aldosterone metabolic process" NARROW []
synonym: "negative regulation of aldosterone metabolism" EXACT []
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032346
name: positive regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "activation of aldosterone metabolic process" NARROW []
synonym: "positive regulation of aldosterone metabolism" EXACT []
synonym: "stimulation of aldosterone metabolic process" NARROW []
synonym: "up regulation of aldosterone metabolic process" EXACT []
synonym: "up-regulation of aldosterone metabolic process" EXACT []
synonym: "upregulation of aldosterone metabolic process" EXACT []
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032347
name: regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032348
name: negative regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
synonym: "down regulation of aldosterone biosynthetic process" EXACT []
synonym: "down-regulation of aldosterone biosynthetic process" EXACT []
synonym: "downregulation of aldosterone biosynthetic process" EXACT []
synonym: "inhibition of aldosterone biosynthetic process" NARROW []
is_a: GO:0032345 ! negative regulation of aldosterone metabolic process
is_a: GO:0032347 ! regulation of aldosterone biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032349
name: positive regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
synonym: "activation of aldosterone biosynthetic process" NARROW []
synonym: "stimulation of aldosterone biosynthetic process" NARROW []
synonym: "up regulation of aldosterone biosynthetic process" EXACT []
synonym: "up-regulation of aldosterone biosynthetic process" EXACT []
synonym: "upregulation of aldosterone biosynthetic process" EXACT []
is_a: GO:0032346 ! positive regulation of aldosterone metabolic process
is_a: GO:0032347 ! regulation of aldosterone biosynthetic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032350
name: regulation of hormone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "regulation of hormone metabolism" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032351
name: negative regulation of hormone metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "down regulation of hormone metabolic process" EXACT []
synonym: "down-regulation of hormone metabolic process" EXACT []
synonym: "downregulation of hormone metabolic process" EXACT []
synonym: "inhibition of hormone metabolic process" NARROW []
synonym: "negative regulation of hormone metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: negatively_regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032352
name: positive regulation of hormone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "activation of hormone metabolic process" NARROW []
synonym: "positive regulation of hormone metabolism" EXACT []
synonym: "stimulation of hormone metabolic process" NARROW []
synonym: "up regulation of hormone metabolic process" EXACT []
synonym: "up-regulation of hormone metabolic process" EXACT []
synonym: "upregulation of hormone metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: positively_regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032353
name: negative regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "down regulation of hormone biosynthetic process" EXACT []
synonym: "down-regulation of hormone biosynthetic process" EXACT []
synonym: "downregulation of hormone biosynthetic process" EXACT []
synonym: "inhibition of hormone biosynthetic process" NARROW []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0032354
name: response to follicle-stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah]
synonym: "response to follicle stimulating hormone stimulus" EXACT []
synonym: "response to follicle-stimulating hormone stimulus" EXACT [GOC:dos]
synonym: "response to FSH stimulus" EXACT []
is_a: GO:0034698 ! response to gonadotropin

[Term]
id: GO:0032355
name: response to estradiol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123]
synonym: "response to E2 stimulus" EXACT []
synonym: "response to estradiol stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032356
name: oxidized DNA binding
namespace: molecular_function
def: "Binding to a DNA region containing an oxidized residue." [GOC:vk]
synonym: "oxidised DNA binding" EXACT []
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:0032357
name: oxidized purine DNA binding
namespace: molecular_function
def: "Binding to a DNA region containing an oxidized purine residue." [GOC:vk]
synonym: "oxidised purine DNA binding" EXACT []
synonym: "oxidized purine base DNA binding" EXACT []
synonym: "oxidized purine nucleobase DNA binding" EXACT []
is_a: GO:0032356 ! oxidized DNA binding

[Term]
id: GO:0032358
name: oxidized pyrimidine DNA binding
namespace: molecular_function
def: "Binding to a DNA region containing an oxidized pyrimidine residue." [GOC:vk]
synonym: "oxidised pyrimidine DNA binding" EXACT []
synonym: "oxidized pyrimidine base DNA binding" EXACT []
synonym: "oxidized pyrimidine nucleobase DNA binding" EXACT []
is_a: GO:0032356 ! oxidized DNA binding

[Term]
id: GO:0032359
name: provirus excision
namespace: biological_process
def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg, VZ:3969]
synonym: "prophage excision" EXACT []
xref: VZ:3969 "Viral genome excision"
is_a: GO:0019046 ! release from viral latency

[Term]
id: GO:0032361
name: pyridoxal phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah]
is_a: GO:0042820 ! vitamin B6 catabolic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0032362
name: obsolete FAD catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide." [GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "FAD breakdown" EXACT [GOC:mah]
synonym: "FAD catabolism" EXACT [GOC:mah]
synonym: "FAD degradation" EXACT [GOC:mah]
synonym: "oxidized flavin adenine dinucleotide catabolic process" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0032363
name: FMN catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah]
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process
is_a: GO:0046444 ! FMN metabolic process

[Term]
id: GO:0032364
name: intracellular oxygen homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell." [GOC:rph]
synonym: "cellular oxygen homeostasis" EXACT []
synonym: "oxygen homeostasis" BROAD []
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0032365
name: intracellular lipid transport
namespace: biological_process
def: "The directed movement of lipids within cells." [GOC:mah]
is_a: GO:0006869 ! lipid transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0032366
name: intracellular sterol transport
namespace: biological_process
def: "The directed movement of sterols within cells." [GOC:mah]
is_a: GO:0015918 ! sterol transport
is_a: GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032367
name: intracellular cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah]
is_a: GO:0030301 ! cholesterol transport
is_a: GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032368
name: regulation of lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
is_a: GO:1905952 ! regulation of lipid localization
relationship: regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032369
name: negative regulation of lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of lipid transport" EXACT []
synonym: "down-regulation of lipid transport" EXACT []
synonym: "downregulation of lipid transport" EXACT []
synonym: "inhibition of lipid transport" NARROW []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1905953 ! negative regulation of lipid localization
relationship: negatively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032370
name: positive regulation of lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of lipid transport" NARROW []
synonym: "stimulation of lipid transport" NARROW []
synonym: "up regulation of lipid transport" EXACT []
synonym: "up-regulation of lipid transport" EXACT []
synonym: "upregulation of lipid transport" EXACT []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1905954 ! positive regulation of lipid localization
relationship: positively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032371
name: regulation of sterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
relationship: regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032372
name: negative regulation of sterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of sterol transport" EXACT []
synonym: "down-regulation of sterol transport" EXACT []
synonym: "downregulation of sterol transport" EXACT []
synonym: "inhibition of sterol transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032371 ! regulation of sterol transport
relationship: negatively_regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032373
name: positive regulation of sterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of sterol transport" NARROW []
synonym: "stimulation of sterol transport" NARROW []
synonym: "up regulation of sterol transport" EXACT []
synonym: "up-regulation of sterol transport" EXACT []
synonym: "upregulation of sterol transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032371 ! regulation of sterol transport
relationship: positively_regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032374
name: regulation of cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032371 ! regulation of sterol transport
relationship: regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032375
name: negative regulation of cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of cholesterol transport" EXACT []
synonym: "down-regulation of cholesterol transport" EXACT []
synonym: "downregulation of cholesterol transport" EXACT []
synonym: "inhibition of cholesterol transport" NARROW []
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: negatively_regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032376
name: positive regulation of cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of cholesterol transport" NARROW []
synonym: "stimulation of cholesterol transport" NARROW []
synonym: "up regulation of cholesterol transport" EXACT []
synonym: "up-regulation of cholesterol transport" EXACT []
synonym: "upregulation of cholesterol transport" EXACT []
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: positively_regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032377
name: regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032378
name: negative regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "down regulation of intracellular lipid transport" EXACT []
synonym: "down-regulation of intracellular lipid transport" EXACT []
synonym: "downregulation of intracellular lipid transport" EXACT []
synonym: "inhibition of intracellular lipid transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032387 ! negative regulation of intracellular transport
relationship: negatively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032379
name: positive regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "activation of intracellular lipid transport" NARROW []
synonym: "stimulation of intracellular lipid transport" NARROW []
synonym: "up regulation of intracellular lipid transport" EXACT []
synonym: "up-regulation of intracellular lipid transport" EXACT []
synonym: "upregulation of intracellular lipid transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032388 ! positive regulation of intracellular transport
relationship: positively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032380
name: regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
is_a: GO:0032371 ! regulation of sterol transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
relationship: regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032381
name: negative regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
synonym: "down regulation of intracellular sterol transport" EXACT []
synonym: "down-regulation of intracellular sterol transport" EXACT []
synonym: "downregulation of intracellular sterol transport" EXACT []
synonym: "inhibition of intracellular sterol transport" NARROW []
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0032378 ! negative regulation of intracellular lipid transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
relationship: negatively_regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032382
name: positive regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
synonym: "activation of intracellular sterol transport" NARROW []
synonym: "stimulation of intracellular sterol transport" NARROW []
synonym: "up regulation of intracellular sterol transport" EXACT []
synonym: "up-regulation of intracellular sterol transport" EXACT []
synonym: "upregulation of intracellular sterol transport" EXACT []
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:0032379 ! positive regulation of intracellular lipid transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
relationship: positively_regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032383
name: regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
is_a: GO:0032374 ! regulation of cholesterol transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
relationship: regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032384
name: negative regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
synonym: "down regulation of intracellular cholesterol transport" EXACT []
synonym: "down-regulation of intracellular cholesterol transport" EXACT []
synonym: "downregulation of intracellular cholesterol transport" EXACT []
synonym: "inhibition of intracellular cholesterol transport" NARROW []
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0032381 ! negative regulation of intracellular sterol transport
is_a: GO:0032383 ! regulation of intracellular cholesterol transport
relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032385
name: positive regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
synonym: "activation of intracellular cholesterol transport" NARROW []
synonym: "stimulation of intracellular cholesterol transport" NARROW []
synonym: "up regulation of intracellular cholesterol transport" EXACT []
synonym: "up-regulation of intracellular cholesterol transport" EXACT []
synonym: "upregulation of intracellular cholesterol transport" EXACT []
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:0032382 ! positive regulation of intracellular sterol transport
is_a: GO:0032383 ! regulation of intracellular cholesterol transport
relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032386
name: regulation of intracellular transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032387
name: negative regulation of intracellular transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "down regulation of intracellular transport" EXACT []
synonym: "down-regulation of intracellular transport" EXACT []
synonym: "downregulation of intracellular transport" EXACT []
synonym: "inhibition of intracellular transport" NARROW []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032388
name: positive regulation of intracellular transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "activation of intracellular transport" NARROW []
synonym: "stimulation of intracellular transport" NARROW []
synonym: "up regulation of intracellular transport" EXACT []
synonym: "up-regulation of intracellular transport" EXACT []
synonym: "upregulation of intracellular transport" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032389
name: MutLalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk]
synonym: "MLH1/PMS2 complex" EXACT []
synonym: "MMR complex" BROAD []
synonym: "MutL-alpha complex" EXACT [CORUM:292]
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032390
name: MutLbeta complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk]
synonym: "MLH1/PMS1 complex" EXACT []
synonym: "MMR complex" BROAD []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032391
name: photoreceptor connecting cilium
namespace: cellular_component
def: "The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone." [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680]
synonym: "photoreceptor cilium" RELATED []
is_a: GO:0035869 ! ciliary transition zone
relationship: part_of GO:0097733 ! photoreceptor cell cilium

[Term]
id: GO:0032392
name: DNA geometric change
namespace: biological_process
def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah]
comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo.
subset: goslim_pir
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0032393
name: MHC class I receptor activity
namespace: molecular_function
def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140375 ! immune receptor activity

[Term]
id: GO:0032394
name: MHC class Ib receptor activity
namespace: molecular_function
def: "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140375 ! immune receptor activity

[Term]
id: GO:0032395
name: MHC class II receptor activity
namespace: molecular_function
def: "Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140375 ! immune receptor activity

[Term]
id: GO:0032396
name: inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134]
is_a: GO:0032393 ! MHC class I receptor activity

[Term]
id: GO:0032397
name: activating MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134]
is_a: GO:0032393 ! MHC class I receptor activity

[Term]
id: GO:0032398
name: MHC class Ib protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0032399
name: HECT domain binding
namespace: molecular_function
def: "Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein." [GOC:mah, Pfam:PF00632]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032400
name: melanosome localization
namespace: biological_process
def: "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln]
synonym: "melanosome localisation" EXACT [GOC:mah]
is_a: GO:0051875 ! pigment granule localization

[Term]
id: GO:0032401
name: establishment of melanosome localization
namespace: biological_process
def: "The directed movement of a melanosome to a specific location." [GOC:mah]
synonym: "establishment of melanosome localisation" EXACT [GOC:mah]
is_a: GO:0051905 ! establishment of pigment granule localization
relationship: part_of GO:0032400 ! melanosome localization

[Term]
id: GO:0032402
name: melanosome transport
namespace: biological_process
def: "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln]
is_a: GO:0032400 ! melanosome localization
is_a: GO:0032401 ! establishment of melanosome localization
is_a: GO:0051904 ! pigment granule transport

[Term]
id: GO:0032404
name: mismatch repair complex binding
namespace: molecular_function
def: "Binding to a mismatch repair complex." [GOC:vk]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0032405
name: MutLalpha complex binding
namespace: molecular_function
def: "Binding to a MutLalpha mismatch repair complex." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032406
name: MutLbeta complex binding
namespace: molecular_function
def: "Binding to a MutLbeta mismatch repair complex." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032407
name: MutSalpha complex binding
namespace: molecular_function
def: "Binding to a MutSalpha mismatch repair complex." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032408
name: MutSbeta complex binding
namespace: molecular_function
def: "Binding to a MutSbeta mismatch repair complex." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032409
name: regulation of transporter activity
namespace: biological_process
def: "Any process that modulates the activity of a transporter." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0032410
name: negative regulation of transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a transporter." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of transporter activity" EXACT []
synonym: "down-regulation of transporter activity" EXACT []
synonym: "downregulation of transporter activity" EXACT []
synonym: "inhibition of transporter activity" NARROW []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051051 ! negative regulation of transport

[Term]
id: GO:0032411
name: positive regulation of transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a transporter." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of transporter activity" NARROW []
synonym: "stimulation of transporter activity" NARROW []
synonym: "up regulation of transporter activity" EXACT []
synonym: "up-regulation of transporter activity" EXACT []
synonym: "upregulation of transporter activity" EXACT []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051050 ! positive regulation of transport

[Term]
id: GO:0032412
name: regulation of monoatomic ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ion transmembrane transporter activity" BROAD []
synonym: "regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0022898 ! regulation of transmembrane transporter activity

[Term]
id: GO:0032413
name: negative regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of ion transporter activity" EXACT []
synonym: "down-regulation of ion transporter activity" EXACT []
synonym: "downregulation of ion transporter activity" EXACT []
synonym: "inhibition of ion transporter activity" NARROW []
synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport

[Term]
id: GO:0032414
name: positive regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "activation of ion transporter activity" NARROW []
synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb]
synonym: "stimulation of ion transporter activity" NARROW []
synonym: "up regulation of ion transporter activity" EXACT []
synonym: "up-regulation of ion transporter activity" EXACT []
synonym: "upregulation of ion transporter activity" EXACT []
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport

[Term]
id: GO:0032415
name: regulation of sodium:proton antiporter activity
namespace: biological_process
def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport]
subset: gocheck_obsoletion_candidate
synonym: "regulation of sodium:hydrogen antiporter activity" EXACT []
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:0032416
name: negative regulation of sodium:proton antiporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW []
synonym: "negative regulation of sodium:hydrogen antiporter activity" EXACT []
is_a: GO:0032415 ! regulation of sodium:proton antiporter activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:0032417
name: positive regulation of sodium:proton antiporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of sodium:hydrogen antiporter activity" NARROW []
synonym: "positive regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW []
synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT []
is_a: GO:0032415 ! regulation of sodium:proton antiporter activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:0032418
name: lysosome localization
namespace: biological_process
def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "lysosome localisation" EXACT [GOC:mah]
is_a: GO:1990849 ! vacuolar localization

[Term]
id: GO:0032419
name: obsolete extrinsic component of lysosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "extrinsic to lysosomal membrane" EXACT []
synonym: "extrinsic to lysosome membrane" EXACT []
is_obsolete: true
consider: GO:0005765

[Term]
id: GO:0032420
name: stereocilium
namespace: cellular_component
def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137]
is_a: GO:0043005 ! neuron projection
is_a: GO:0098858 ! actin-based cell projection
relationship: part_of GO:0032421 ! stereocilium bundle
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0032421
name: stereocilium bundle
namespace: cellular_component
def: "A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137]
subset: goslim_pir
synonym: "stereocilia bundle" EXACT []
is_a: GO:0098862 ! cluster of actin-based cell projections

[Term]
id: GO:0032422
name: purine-rich negative regulatory element binding
namespace: molecular_function
def: "Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411]
synonym: "PNR element binding" BROAD []
is_a: GO:0000976 ! transcription cis-regulatory region binding

[Term]
id: GO:0032423
name: regulation of mismatch repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk]
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032424
name: negative regulation of mismatch repair
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair." [GOC:vk]
synonym: "down regulation of mismatch repair" EXACT []
synonym: "down-regulation of mismatch repair" EXACT []
synonym: "downregulation of mismatch repair" EXACT []
synonym: "inhibition of mismatch repair" NARROW []
is_a: GO:0032423 ! regulation of mismatch repair
is_a: GO:0045738 ! negative regulation of DNA repair
relationship: negatively_regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032425
name: positive regulation of mismatch repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk]
synonym: "activation of mismatch repair" NARROW []
synonym: "stimulation of mismatch repair" NARROW []
synonym: "up regulation of mismatch repair" EXACT []
synonym: "up-regulation of mismatch repair" EXACT []
synonym: "upregulation of mismatch repair" EXACT []
is_a: GO:0032423 ! regulation of mismatch repair
is_a: GO:0045739 ! positive regulation of DNA repair
relationship: positively_regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032426
name: stereocilium tip
namespace: cellular_component
def: "A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation." [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0032427
name: GBD domain binding
namespace: molecular_function
def: "Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac." [GOC:mah, GOC:pg, PMID:9119069]
synonym: "Cdc42/Rac interactive binding motif binding" EXACT [PMID:9119069]
synonym: "CRIB motif binding" EXACT [PMID:9119069]
synonym: "P21-Rho-binding domain binding" EXACT [GOC:rl]
synonym: "PMD binding" EXACT [GOC:rl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032428
name: beta-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53]
xref: EC:3.2.1.53
xref: MetaCyc:3.2.1.53-RXN
is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity

[Term]
id: GO:0032429
name: regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0010517 ! regulation of phospholipase activity

[Term]
id: GO:0032430
name: positive regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of phospholipase A2 activity" NARROW []
synonym: "stimulation of phospholipase A2 activity" NARROW []
synonym: "up regulation of phospholipase A2 activity" EXACT []
synonym: "up-regulation of phospholipase A2 activity" EXACT []
synonym: "upregulation of phospholipase A2 activity" EXACT []
is_a: GO:0010518 ! positive regulation of phospholipase activity
is_a: GO:0032429 ! regulation of phospholipase A2 activity

[Term]
id: GO:0032431
name: activation of phospholipase A2 activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "phospholipase A2 activation" EXACT []
is_a: GO:0032430 ! positive regulation of phospholipase A2 activity

[Term]
id: GO:0032432
name: actin filament bundle
namespace: cellular_component
alt_id: GO:0000141
alt_id: GO:0030482
def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]
synonym: "actin cable" RELATED [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0032433
name: filopodium tip
namespace: cellular_component
def: "The end of a filopodium distal to the body of the cell." [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0032434
name: regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process
relationship: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032435
name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process
is_a: GO:2000059 ! negative regulation of ubiquitin-dependent protein catabolic process
relationship: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032436
name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process
is_a: GO:2000060 ! positive regulation of ubiquitin-dependent protein catabolic process
relationship: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032437
name: cuticular plate
namespace: cellular_component
def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0032438
name: melanosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk]
synonym: "melanosome organisation" EXACT [GOC:mah]
synonym: "melanosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0032440
name: 2-alkenal reductase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.3.1.74]
synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" RELATED [EC:1.3.1.74]
xref: EC:1.3.1.74
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032441
name: pheophorbide a oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O." [PMID:14657372]
xref: EC:1.14.15.17
xref: MetaCyc:RXN-7740
xref: RHEA:48140
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0032442
name: phenylcoumaran benzylic ether reductase activity
namespace: molecular_function
def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+." [PMID:11030549, PMID:13129921]
synonym: "PCBER activity" EXACT []
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032443
name: regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah]
is_a: GO:0106118 ! regulation of sterol biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0032444
name: activin responsive factor complex
namespace: cellular_component
def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972]
comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor).
synonym: "ARF complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0032446
name: protein modification by small protein conjugation
namespace: biological_process
def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]
is_a: GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:0032447
name: protein urmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw]
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0032448
name: DNA hairpin binding
namespace: molecular_function
def: "Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0032449
name: CBM complex
namespace: cellular_component
def: "A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation." [PMID:12909454, PMID:30467369]
synonym: "CARMA1-BCL10-Malt1 complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0032450
name: obsolete maltose alpha-glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
comment: This term was obsoleted because it represents a specific substrate of alpha-1,4-glucosidase activity ; GO:0004558.
synonym: "maltase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004558

[Term]
id: GO:0032451
name: demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah]
subset: goslim_pir
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0032452
name: histone demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah]
xref: Reactome:R-HSA-3214912 "KDM1A, KDM1B demethylate MeK5-histone H3"
xref: Reactome:R-HSA-4722133 "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3"
xref: Reactome:R-HSA-4724279 "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3"
xref: Reactome:R-HSA-4724284 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3"
xref: Reactome:R-HSA-4754176 "JMJD6 demethylates MeR3-histone H3"
xref: Reactome:R-HSA-4754181 "KDM5A-D demethylate Me2K5-histone H3"
xref: Reactome:R-HSA-4754187 "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3"
xref: Reactome:R-HSA-5423117 "PHF8 demethylates MeK21-histone H4"
xref: Reactome:R-HSA-5625797 "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters"
xref: Reactome:R-HSA-5625848 "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters"
xref: Reactome:R-HSA-5625870 "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters"
xref: Reactome:R-HSA-5661114 "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3"
xref: Reactome:R-HSA-5661115 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3"
xref: Reactome:R-HSA-5661116 "KDM5A-D demethylate Me3K5-histone H3"
xref: Reactome:R-HSA-5661120 "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3"
xref: Reactome:R-HSA-5661121 "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3"
xref: Reactome:R-HSA-5661122 "JMJD6 demethylates Me2R3-histone H3"
xref: Reactome:R-HSA-5661123 "KDM1A, KDM1B demethylate Me2K5-histone H3"
xref: Reactome:R-HSA-5661124 "JMJD6 demethylates MeR4-HIST1H4"
xref: Reactome:R-HSA-5661125 "JMJD6 demethylates Me2sR4-HIST1H4"
is_a: GO:0140457 ! protein demethylase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0032453
name: histone H3K4 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein." [GOC:mah]
synonym: "histone demethylase activity (H3-K4 specific)" EXACT []
synonym: "histone demethylase activity (H3K4-specific)" EXACT []
synonym: "histone H3-K4 demethylase activity" EXACT []
synonym: "histone H3-methyl-lysine-4 demethylase activity" EXACT []
xref: Reactome:R-HSA-9822461 "KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3)"
xref: Reactome:R-HSA-9822467 "KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)"
is_a: GO:0141052 ! histone H3 demethylase activity

[Term]
id: GO:0032454
name: histone H3K9 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057]
synonym: "histone demethylase activity (H3-K9 specific)" EXACT []
synonym: "histone H3-K49 demethylase activity" EXACT []
synonym: "histone H3-methyl-lysine-9 demethylase activity" EXACT []
xref: Reactome:R-HSA-9011949 "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers"
xref: Reactome:R-HSA-9011985 "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen"
xref: Reactome:R-HSA-997263 "JMJD1C demethylates H3K9 mono- and di-methylation"
is_a: GO:0141052 ! histone H3 demethylase activity

[Term]
id: GO:0032455
name: nerve growth factor processing
namespace: biological_process
def: "The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor." [GOC:mah, PMID:8615794]
synonym: "beta-nerve growth factor processing" EXACT [PR:000011194]
synonym: "NGF processing" EXACT [PR:000011194]
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0032456
name: endocytic recycling
namespace: biological_process
alt_id: GO:1990126
def: "The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]
synonym: "retrograde transport of endocytic vesicles" RELATED []
synonym: "retrograde transport, endosome to plasma membrane" EXACT []
is_a: GO:0016197 ! endosomal transport
is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane

[Term]
id: GO:0032457
name: fast endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
synonym: "direct endocytic recycling" EXACT []
is_a: GO:0032456 ! endocytic recycling

[Term]
id: GO:0032458
name: slow endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
is_a: GO:0032456 ! endocytic recycling

[Term]
id: GO:0032459
name: regulation of protein oligomerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0032460
name: negative regulation of protein oligomerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah]
synonym: "down regulation of protein oligomerization" EXACT []
synonym: "down-regulation of protein oligomerization" EXACT []
synonym: "downregulation of protein oligomerization" EXACT []
synonym: "inhibition of protein oligomerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0032459 ! regulation of protein oligomerization
relationship: negatively_regulates GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0032461
name: positive regulation of protein oligomerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah]
synonym: "activation of protein oligomerization" NARROW []
synonym: "induction of protein oligomerization" RELATED []
synonym: "stimulation of protein oligomerization" NARROW []
synonym: "up regulation of protein oligomerization" EXACT []
synonym: "up-regulation of protein oligomerization" EXACT []
synonym: "upregulation of protein oligomerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0032459 ! regulation of protein oligomerization
relationship: positively_regulates GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0032462
name: regulation of protein homooligomerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah]
is_a: GO:0032459 ! regulation of protein oligomerization
relationship: regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032463
name: negative regulation of protein homooligomerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah]
synonym: "down regulation of protein homooligomerization" EXACT []
synonym: "down-regulation of protein homooligomerization" EXACT []
synonym: "downregulation of protein homooligomerization" EXACT []
synonym: "inhibition of protein homooligomerization" NARROW []
is_a: GO:0032460 ! negative regulation of protein oligomerization
is_a: GO:0032462 ! regulation of protein homooligomerization
relationship: negatively_regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032464
name: positive regulation of protein homooligomerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah]
synonym: "activation of protein homooligomerization" NARROW []
synonym: "induction of protein homooligomerization" RELATED []
synonym: "stimulation of protein homooligomerization" NARROW []
synonym: "up regulation of protein homooligomerization" EXACT []
synonym: "up-regulation of protein homooligomerization" EXACT []
synonym: "upregulation of protein homooligomerization" EXACT []
is_a: GO:0032461 ! positive regulation of protein oligomerization
is_a: GO:0032462 ! regulation of protein homooligomerization
relationship: positively_regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032465
name: regulation of cytokinesis
namespace: biological_process
alt_id: GO:0071775
def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]
synonym: "regulation of cell cycle cytokinesis" EXACT []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032466
name: negative regulation of cytokinesis
namespace: biological_process
alt_id: GO:0071776
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]
synonym: "down regulation of cytokinesis" EXACT []
synonym: "down-regulation of cytokinesis" EXACT []
synonym: "downregulation of cytokinesis" EXACT []
synonym: "inhibition of cytokinesis" NARROW []
synonym: "negative regulation of cell cycle cytokinesis" RELATED []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:0051782 ! negative regulation of cell division
relationship: negatively_regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032467
name: positive regulation of cytokinesis
namespace: biological_process
alt_id: GO:0071777
def: "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]
synonym: "activation of cytokinesis" NARROW []
synonym: "positive regulation of cell cycle cytokinesis" RELATED []
synonym: "stimulation of cytokinesis" NARROW []
synonym: "up regulation of cytokinesis" EXACT []
synonym: "up-regulation of cytokinesis" EXACT []
synonym: "upregulation of cytokinesis" EXACT []
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032468
name: Golgi calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah]
synonym: "calcium ion homeostasis in Golgi" EXACT []
synonym: "Golgi calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in Golgi" EXACT []
synonym: "regulation of Golgi calcium ion concentration" EXACT []
is_a: GO:0006874 ! intracellular calcium ion homeostasis

[Term]
id: GO:0032469
name: endoplasmic reticulum calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]
synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT []
synonym: "calcium ion homeostasis in ER" EXACT []
synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT []
synonym: "ER calcium ion concentration regulation" EXACT []
synonym: "ER calcium ion homeostasis" EXACT []
synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "regulation of calcium ion concentration in ER" EXACT []
synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "regulation of ER calcium ion concentration" EXACT []
is_a: GO:0006874 ! intracellular calcium ion homeostasis

[Term]
id: GO:0032470
name: positive regulation of endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]
synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "elevation of endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "elevation of ER calcium ion concentration" EXACT []
synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0032471
name: negative regulation of endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]
synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT []
synonym: "ER calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "reduction of calcium ion concentration in ER" EXACT []
synonym: "reduction of endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "reduction of ER calcium ion concentration" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0032472
name: Golgi calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah]
synonym: "Golgi calcium transport" EXACT []
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0032473
name: cytoplasmic side of mitochondrial outer membrane
namespace: cellular_component
def: "The external (cytoplasmic) face of the mitochondrial outer membrane." [GOC:mah]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
synonym: "cytosolic side of mitochondrial outer membrane" EXACT []
synonym: "external leaflet of mitochondrial outer membrane" EXACT [GOC:ab]
synonym: "external side of mitochondrial envelope" RELATED []
synonym: "external side of mitochondrial outer membrane" EXACT []
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0032474
name: otolith morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an otolith are generated and organized." [GOC:dgh]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0048840 ! otolith development

[Term]
id: GO:0032475
name: otolith formation
namespace: biological_process
def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0032474 ! otolith morphogenesis

[Term]
id: GO:0032476
name: polyprenyl diphosphate synthase complex
namespace: cellular_component
def: "A complex that possesses polyprenyl diphosphate synthase activity involved in the synthesis of the isoprenoid chain of ubiquinone whose length varies between organisms." [GOC:mah, PMID:14519123, PMID:16262699]
subset: goslim_pir
synonym: "decaprenyl diphosphate synthase complex" NARROW []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0032477
name: homodimeric polyprenyl diphosphate synthase complex
namespace: cellular_component
def: "A homodimeric complex that possesses polyprenyl diphosphate synthase activity involved in the synthesis of the isoprenoid chain of ubiquinone whose length varies between organisms." [PMID:14519123]
synonym: "homodimeric decaprenyl diphosphate synthase complex" NARROW []
is_a: GO:0032476 ! polyprenyl diphosphate synthase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0032478
name: heterotetrameric polyprenyl diphosphate synthase complex
namespace: cellular_component
def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses polyprenyl diphosphate synthase activity involved in the synthesis of the isoprenoid chain of ubiquinone whose length varies between organisms. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123, PMID:16262699]
synonym: "heterotetrameric decaprenyl diphosphate synthase complex" NARROW []
is_a: GO:0032476 ! polyprenyl diphosphate synthase complex
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:0032479
name: regulation of type I interferon production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "regulation of type I IFN production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032480
name: negative regulation of type I interferon production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "down regulation of type I interferon production" EXACT []
synonym: "down-regulation of type I interferon production" EXACT []
synonym: "downregulation of type I interferon production" EXACT []
synonym: "inhibition of type I interferon production" NARROW []
synonym: "negative regulation of type I IFN production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032479 ! regulation of type I interferon production
relationship: negatively_regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032481
name: positive regulation of type I interferon production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "activation of type I interferon production" NARROW []
synonym: "positive regulation of type I IFN production" EXACT []
synonym: "stimulation of type I interferon production" NARROW []
synonym: "up regulation of type I interferon production" EXACT []
synonym: "up-regulation of type I interferon production" EXACT []
synonym: "upregulation of type I interferon production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032479 ! regulation of type I interferon production
relationship: positively_regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032482
name: Rab protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0032483
name: regulation of Rab protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0032482 ! Rab protein signal transduction

[Term]
id: GO:0032484
name: Ral protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the RaI subfamily relays a signal." [GOC:mah]
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0032485
name: regulation of Ral protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0032484 ! Ral protein signal transduction

[Term]
id: GO:0032486
name: Rap protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal." [GOC:mah]
is_a: GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0032487
name: regulation of Rap protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0032486 ! Rap protein signal transduction

[Term]
id: GO:0032488
name: Cdc42 protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]
synonym: "Cdc42 signaling" RELATED [GOC:vw]
synonym: "Cdc42 signaling pathway" RELATED [GOC:vw]
synonym: "cdc42 signalling pathway" RELATED [GOC:vw]
is_a: GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0032489
name: regulation of Cdc42 protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah]
is_a: GO:0035023 ! regulation of Rho protein signal transduction
relationship: regulates GO:0032488 ! Cdc42 protein signal transduction

[Term]
id: GO:0032490
name: detection of molecule of bacterial origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl]
synonym: "detection of bacteria associated molecule" EXACT []
synonym: "detection of bacterial associated molecule" EXACT []
synonym: "detection of bacterium associated molecule" EXACT []
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0098581 ! detection of external biotic stimulus

[Term]
id: GO:0032491
name: detection of molecule of fungal origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
synonym: "detection of fungal associated molecule" EXACT []
synonym: "detection of fungus associated molecule" EXACT []
is_a: GO:0002238 ! response to molecule of fungal origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0098581 ! detection of external biotic stimulus

[Term]
id: GO:0032492
name: detection of molecule of oomycetes origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
synonym: "detection of oomycetes associated molecule" EXACT []
is_a: GO:0002240 ! response to molecule of oomycetes origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0098581 ! detection of external biotic stimulus

[Term]
id: GO:0032493
name: response to bacterial lipoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222]
is_a: GO:0002237 ! response to molecule of bacterial origin

[Term]
id: GO:0032494
name: response to peptidoglycan
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032495
name: response to muramyl dipeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032496
name: response to lipopolysaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]
synonym: "response to endotoxin" BROAD [GOC:sl]
synonym: "response to LPS" EXACT []
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032497
name: detection of lipopolysaccharide
namespace: biological_process
def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797]
synonym: "detection of LPS" EXACT []
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032496 ! response to lipopolysaccharide

[Term]
id: GO:0032498
name: detection of muramyl dipeptide
namespace: biological_process
def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797]
is_a: GO:0032495 ! response to muramyl dipeptide
is_a: GO:0032499 ! detection of peptidoglycan

[Term]
id: GO:0032499
name: detection of peptidoglycan
namespace: biological_process
def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032494 ! response to peptidoglycan

[Term]
id: GO:0032500
name: muramyl dipeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl]
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0032501
name: multicellular organismal process
namespace: biological_process
alt_id: GO:0044707
alt_id: GO:0050874
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "organismal physiological process" EXACT []
synonym: "single-multicellular organism process" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032502
name: developmental process
namespace: biological_process
alt_id: GO:0044767
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_pir
synonym: "development" NARROW []
synonym: "single-organism developmental process" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032504
name: obsolete multicellular organism reproduction
namespace: biological_process
def: "OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
comment: The reason for obsoletion is that this term is equivalent to multicellular organismal reproductive process.
is_obsolete: true
replaced_by: GO:0048609

[Term]
id: GO:0032505
name: obsolete reproduction of a single-celled organism
namespace: biological_process
def: "OBSOLETE. The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete]
comment: The reason for obsoletion is that this term is equivalent to reproductive process in single-celled organism.
is_obsolete: true
replaced_by: GO:0022413

[Term]
id: GO:0032506
name: cytokinetic process
namespace: biological_process
def: "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells)." [GOC:bf, GOC:isa_complete, GOC:mah]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000910 ! cytokinesis

[Term]
id: GO:0032507
name: maintenance of protein location in cell
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]
synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb]
is_a: GO:0045185 ! maintenance of protein location
is_a: GO:0051651 ! maintenance of location in cell

[Term]
id: GO:0032508
name: DNA duplex unwinding
namespace: biological_process
def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
synonym: "DNA unwinding" EXACT []
synonym: "duplex DNA melting" EXACT []
is_a: GO:0032392 ! DNA geometric change

[Term]
id: GO:0032509
name: endosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome transport via MVB sorting pathway" EXACT []
is_a: GO:0016197 ! endosomal transport
is_a: GO:0071985 ! multivesicular body sorting pathway

[Term]
id: GO:0032510
name: endosome to lysosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT []
is_a: GO:0008333 ! endosome to lysosome transport
is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway

[Term]
id: GO:0032511
name: late endosome to vacuole transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT []
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway
is_a: GO:0045324 ! late endosome to vacuole transport

[Term]
id: GO:0032515
name: obsolete negative regulation of phosphoprotein phosphatase activity
namespace: biological_process
alt_id: GO:0032513
alt_id: GO:0034048
def: "OBSOLETE. Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "down regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl]
synonym: "down regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "down regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "down regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "down regulation of protein phosphatase type 2A activity" NARROW []
synonym: "down regulation of protein phosphatase type 2B activity" NARROW []
synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "down-regulation of protein phosphatase type 2A activity" NARROW []
synonym: "down-regulation of protein phosphatase type 2B activity" NARROW []
synonym: "downregulation of calcineurin activity" NARROW [GOC:dph, GOC:rl]
synonym: "downregulation of phosphoprotein phosphatase activity" EXACT []
synonym: "downregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "downregulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "downregulation of protein phosphatase type 2A activity" NARROW []
synonym: "downregulation of protein phosphatase type 2B activity" NARROW []
synonym: "inhibition of calcineurin activity" NARROW [GOC:dph, GOC:rl]
synonym: "inhibition of phosphoprotein phosphatase activity" NARROW []
synonym: "inhibition of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "inhibition of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "inhibition of protein phosphatase type 2A activity" NARROW []
synonym: "inhibition of protein phosphatase type 2B activity" NARROW []
synonym: "negative regulation of calcineurin activity" NARROW []
synonym: "negative regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "negative regulation of protein phosphatase type 2A activity" NARROW []
synonym: "negative regulation of protein phosphatase type 2B activity" NARROW []
synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
is_obsolete: true

[Term]
id: GO:0032516
name: obsolete positive regulation of phosphoprotein phosphatase activity
namespace: biological_process
alt_id: GO:0032514
alt_id: GO:0034049
def: "OBSOLETE. Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "activation of calcineurin activity" NARROW [GOC:dph, GOC:rl]
synonym: "activation of phosphoprotein phosphatase activity" NARROW []
synonym: "activation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "activation of protein phosphatase type 2A activity" NARROW []
synonym: "activation of protein phosphatase type 2B activity" NARROW []
synonym: "calcineurin activation" NARROW []
synonym: "positive regulation of calcineurin activity" NARROW []
synonym: "positive regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "positive regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "positive regulation of protein phosphatase type 2A activity" NARROW []
synonym: "positive regulation of protein phosphatase type 2B activity" NARROW []
synonym: "stimulation of phosphoprotein phosphatase activity" NARROW []
synonym: "stimulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "stimulation of protein phosphatase type 2A activity" NARROW []
synonym: "stimulation of protein phosphatase type 2B activity" NARROW []
synonym: "up regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl]
synonym: "up regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "up regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "up regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "up regulation of protein phosphatase type 2A activity" NARROW []
synonym: "up regulation of protein phosphatase type 2B activity" NARROW []
synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "up-regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "up-regulation of protein phosphatase type 2A activity" NARROW []
synonym: "up-regulation of protein phosphatase type 2B activity" NARROW []
synonym: "upregulation of phosphoprotein phosphatase activity" EXACT []
synonym: "upregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "upregulation of protein phosphatase type 2A activity" NARROW []
synonym: "upregulation of protein phosphatase type 2B activity" NARROW []
is_obsolete: true

[Term]
id: GO:0032517
name: SOD1-calcineurin complex
namespace: cellular_component
def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0032523
name: silicon efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566]
synonym: "silicon efflux transporter activity" EXACT []
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0032524
name: obsolete nutrient export
namespace: biological_process
def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah]
comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning.
synonym: "nutrient export" EXACT []
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0032525
name: somite rostral/caudal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776]
synonym: "somite rostrocaudal axis specification" EXACT []
synonym: "somite rostrocaudal polarity" RELATED []
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0032526
name: response to retinoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl]
synonym: "response to vitamin A acid" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032527
name: protein exit from endoplasmic reticulum
namespace: biological_process
def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb]
synonym: "protein exit from ER" EXACT []
synonym: "protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "protein export from ER" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0032528
name: microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah]
synonym: "microvillus organisation" EXACT [GOC:mah]
synonym: "microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0032529
name: follicle cell microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588]
synonym: "follicle cell microvillus organisation" EXACT [GOC:mah]
synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032528 ! microvillus organization

[Term]
id: GO:0032530
name: regulation of microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah]
synonym: "regulation of microvillus organisation" EXACT [GOC:mah]
synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
relationship: regulates GO:0032528 ! microvillus organization

[Term]
id: GO:0032531
name: regulation of follicle cell microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah]
synonym: "regulation of follicle cell microvillus organisation" EXACT [GOC:mah]
synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
relationship: regulates GO:0032529 ! follicle cell microvillus organization

[Term]
id: GO:0032532
name: regulation of microvillus length
namespace: biological_process
def: "A process that modulates the length of a microvillus." [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0032536 ! regulation of cell projection size

[Term]
id: GO:0032533
name: regulation of follicle cell microvillus length
namespace: biological_process
def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500]
is_a: GO:0008361 ! regulation of cell size
is_a: GO:0032531 ! regulation of follicle cell microvillus organization
is_a: GO:0032532 ! regulation of microvillus length

[Term]
id: GO:0032534
name: regulation of microvillus assembly
namespace: biological_process
def: "A process that modulates the formation of a microvillus." [GOC:mah]
synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: regulates GO:0030033 ! microvillus assembly

[Term]
id: GO:0032535
name: regulation of cellular component size
namespace: biological_process
def: "A process that modulates the size of a cellular component." [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0032536
name: regulation of cell projection size
namespace: biological_process
def: "A process that modulates the size of a cell projection." [GOC:mah]
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0032537
name: host-seeking behavior
namespace: biological_process
def: "The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, GOC:pr, PMID:11931033]
synonym: "host-seeking behaviour" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0032538
name: regulation of host-seeking behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "regulation of host-seeking behaviour" EXACT []
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032539
name: negative regulation of host-seeking behavior
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "down regulation of host-seeking behavior" EXACT []
synonym: "down-regulation of host-seeking behavior" EXACT []
synonym: "downregulation of host-seeking behavior" EXACT []
synonym: "inhibition of host-seeking behavior" NARROW []
synonym: "negative regulation of host-seeking behaviour" EXACT []
is_a: GO:0032538 ! regulation of host-seeking behavior
is_a: GO:0048521 ! negative regulation of behavior
relationship: negatively_regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032540
name: positive regulation of host-seeking behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "activation of host-seeking behavior" NARROW []
synonym: "positive regulation of host-seeking behaviour" EXACT []
synonym: "stimulation of host-seeking behavior" NARROW []
synonym: "up regulation of host-seeking behavior" EXACT []
synonym: "up-regulation of host-seeking behavior" EXACT []
synonym: "upregulation of host-seeking behavior" EXACT []
is_a: GO:0032538 ! regulation of host-seeking behavior
is_a: GO:0048520 ! positive regulation of behavior
relationship: positively_regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032541
name: cortical endoplasmic reticulum
namespace: cellular_component
def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782]
comment: The dynamic nature of the cortical ER and the movements it undergoes (branching and ring closure) has been shown in both yeast and mammalian cells, so appears highly conserved. (PMID:10931860)
synonym: "cortical ER" EXACT []
synonym: "ER-PM peripheral junction" BROAD [GOC:ans, PMID:21062895]
synonym: "peripheral endoplasmic reticulum" RELATED []
synonym: "peripheral ER" RELATED []
is_a: GO:0071782 ! endoplasmic reticulum tubular network
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0032542
name: sulfiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934]
synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT []
synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2]
synonym: "Srx1" RELATED [EC:1.8.98.2]
synonym: "sulphiredoxin activity" EXACT []
xref: EC:1.8.98.2
xref: MetaCyc:1.8.98.2-RXN
xref: Reactome:R-HSA-9760094 "SRXN1 reduces hyperoxidized PRDX1 dimer"
xref: RHEA:17545
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0032543
name: mitochondrial translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
subset: goslim_yeast
synonym: "mitochondrial protein anabolism" EXACT []
synonym: "mitochondrial protein biosynthesis" EXACT []
synonym: "mitochondrial protein formation" EXACT []
synonym: "mitochondrial protein synthesis" EXACT []
synonym: "mitochondrial protein translation" EXACT []
is_a: GO:0006412 ! translation
relationship: part_of GO:0140053 ! mitochondrial gene expression

[Term]
id: GO:0032544
name: plastid translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
synonym: "plastid protein anabolism" EXACT []
synonym: "plastid protein biosynthesis" EXACT []
synonym: "plastid protein formation" EXACT []
synonym: "plastid protein synthesis" EXACT []
synonym: "plastid protein translation" EXACT []
is_a: GO:0006412 ! translation
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0032545
name: CURI complex
namespace: cellular_component
def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p." [PMID:17452446]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032546
name: deoxyribonucleoside binding
namespace: molecular_function
def: "Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0032547
name: purine deoxyribonucleoside binding
namespace: molecular_function
def: "Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah]
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032546 ! deoxyribonucleoside binding

[Term]
id: GO:0032548
name: pyrimidine deoxyribonucleoside binding
namespace: molecular_function
def: "Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah]
is_a: GO:0001884 ! pyrimidine nucleoside binding
is_a: GO:0032546 ! deoxyribonucleoside binding

[Term]
id: GO:0032549
name: ribonucleoside binding
namespace: molecular_function
def: "Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0032550
name: purine ribonucleoside binding
namespace: molecular_function
def: "Binding to a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah]
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032549 ! ribonucleoside binding

[Term]
id: GO:0032551
name: pyrimidine ribonucleoside binding
namespace: molecular_function
def: "Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah]
is_a: GO:0001884 ! pyrimidine nucleoside binding
is_a: GO:0032549 ! ribonucleoside binding

[Term]
id: GO:0032552
name: deoxyribonucleotide binding
namespace: molecular_function
def: "Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0032553
name: ribonucleotide binding
namespace: molecular_function
def: "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0032554
name: purine deoxyribonucleotide binding
namespace: molecular_function
def: "Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
is_a: GO:0017076 ! purine nucleotide binding
is_a: GO:0032552 ! deoxyribonucleotide binding

[Term]
id: GO:0032555
name: purine ribonucleotide binding
namespace: molecular_function
def: "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
is_a: GO:0017076 ! purine nucleotide binding
is_a: GO:0032553 ! ribonucleotide binding

[Term]
id: GO:0032556
name: pyrimidine deoxyribonucleotide binding
namespace: molecular_function
def: "Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
is_a: GO:0019103 ! pyrimidine nucleotide binding
is_a: GO:0032552 ! deoxyribonucleotide binding

[Term]
id: GO:0032557
name: pyrimidine ribonucleotide binding
namespace: molecular_function
def: "Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
is_a: GO:0019103 ! pyrimidine nucleotide binding
is_a: GO:0032553 ! ribonucleotide binding

[Term]
id: GO:0032558
name: adenyl deoxyribonucleotide binding
namespace: molecular_function
def: "Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0032554 ! purine deoxyribonucleotide binding

[Term]
id: GO:0032559
name: adenyl ribonucleotide binding
namespace: molecular_function
def: "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0032555 ! purine ribonucleotide binding

[Term]
id: GO:0032560
name: guanyl deoxyribonucleotide binding
namespace: molecular_function
def: "Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
is_a: GO:0019001 ! guanyl nucleotide binding
is_a: GO:0032554 ! purine deoxyribonucleotide binding

[Term]
id: GO:0032561
name: guanyl ribonucleotide binding
namespace: molecular_function
def: "Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
is_a: GO:0019001 ! guanyl nucleotide binding
is_a: GO:0032555 ! purine ribonucleotide binding

[Term]
id: GO:0032562
name: dAMP binding
namespace: molecular_function
def: "Binding to dAMP, deoxyadenosine monophosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032563
name: dADP binding
namespace: molecular_function
def: "Binding to dADP, deoxyadenosine diphosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032564
name: dATP binding
namespace: molecular_function
def: "Binding to dATP, deoxyadenosine triphosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032565
name: dGMP binding
namespace: molecular_function
def: "Binding to dGMP, deoxyguanosine monophosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032566
name: dGDP binding
namespace: molecular_function
def: "Binding to dGDP, deoxyguanosine diphosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032567
name: dGTP binding
namespace: molecular_function
def: "Binding to dGTP, deoxyguanosine triphosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032570
name: response to progesterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl]
synonym: "response to progesterone stimulus" EXACT [GOC:dos]
is_a: GO:0048545 ! response to steroid hormone
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0032571
name: response to vitamin K
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl]
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0032572
name: response to menaquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl]
synonym: "response to menatetrenone" EXACT []
synonym: "response to vitamin K2" EXACT []
is_a: GO:0032571 ! response to vitamin K

[Term]
id: GO:0032573
name: response to phylloquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl]
synonym: "response to vitamin K1" EXACT []
is_a: GO:0032571 ! response to vitamin K

[Term]
id: GO:0032574
name: 5'-3' RNA helicase activity
namespace: molecular_function
alt_id: GO:0032575
def: "Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [GOC:jp]
synonym: "5' to 3' RNA helicase activity" EXACT []
synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT []
synonym: "ATP-dependent 5'-3' RNA helicase activity" EXACT []
xref: EC:5.6.2.5
xref: Reactome:R-HSA-9682695 "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template"
xref: Reactome:R-HSA-9694265 "nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template"
is_a: GO:0003724 ! RNA helicase activity

[Term]
id: GO:0032576
name: O-linoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0032577
name: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah]
synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT []
is_a: GO:0032576 ! O-linoleoyltransferase activity

[Term]
id: GO:0032578
name: aleurone grain membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0033095 ! aleurone grain

[Term]
id: GO:0032579
name: apical lamina of hyaline layer
namespace: cellular_component
def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0033166 ! hyaline layer

[Term]
id: GO:0032580
name: Golgi cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
synonym: "Golgi apparatus cisterna membrane" EXACT []
synonym: "Golgi stack membrane" EXACT []
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0031985 ! Golgi cisterna

[Term]
id: GO:0032581
name: ER-dependent peroxisome organization
namespace: biological_process
def: "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum." [GOC:mah, PMID:16717127, PMID:17646399]
synonym: "endoplasmic reticulum-dependent peroxisome organization" EXACT [GOC:mah]
synonym: "ER-dependent peroxisome biogenesis" RELATED [GOC:mah]
synonym: "ER-dependent peroxisome organisation" EXACT [GOC:mah]
is_a: GO:0007031 ! peroxisome organization

[Term]
id: GO:0032584
name: growth cone membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0030426 ! growth cone

[Term]
id: GO:0032585
name: multivesicular body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah]
synonym: "multivesicular endosome membrane" EXACT []
synonym: "MVB membrane" EXACT []
synonym: "MVE membrane" EXACT []
is_a: GO:0031902 ! late endosome membrane
relationship: part_of GO:0005771 ! multivesicular body

[Term]
id: GO:0032586
name: protein storage vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah]
is_a: GO:0009705 ! plant-type vacuole membrane
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0032587
name: ruffle membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah]
synonym: "membrane ruffle" RELATED []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0001726 ! ruffle

[Term]
id: GO:0032588
name: trans-Golgi network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]
synonym: "Golgi trans face membrane" RELATED []
synonym: "trans Golgi network membrane" EXACT []
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0005802 ! trans-Golgi network

[Term]
id: GO:0032589
name: neuron projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0032590
name: dendrite membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah]
is_a: GO:0032589 ! neuron projection membrane
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0032591
name: dendritic spine membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah]
is_a: GO:0032589 ! neuron projection membrane
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0032590 ! dendrite membrane
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0032592
name: obsolete integral component of mitochondrial membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to mitochondrial membrane" NARROW []
is_obsolete: true
replaced_by: GO:0031966

[Term]
id: GO:0032593
name: insulin-responsive compartment
namespace: cellular_component
def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329]
synonym: "GLUT4 storage compartment" EXACT []
synonym: "GSC" RELATED []
synonym: "IRC" RELATED []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0032594
name: protein transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah]
synonym: "protein translocation within membrane" EXACT []
synonym: "receptor translocation within membrane" NARROW []
synonym: "receptor transport within lipid bilayer" NARROW []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0032595
name: B cell receptor transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah]
synonym: "B cell receptor translocation within membrane" EXACT []
synonym: "BCR translocation within membrane" EXACT []
synonym: "BCR transport within lipid bilayer" EXACT []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0032596
name: protein transport into membrane raft
namespace: biological_process
def: "The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah]
synonym: "protein translocation into membrane raft" EXACT []
synonym: "protein transport into lipid raft" EXACT []
synonym: "receptor translocation into membrane raft" NARROW []
synonym: "receptor transport into membrane raft" NARROW []
is_a: GO:0032594 ! protein transport within lipid bilayer
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:1903044 ! protein localization to membrane raft

[Term]
id: GO:0032597
name: B cell receptor transport into membrane raft
namespace: biological_process
def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah]
synonym: "B cell receptor translocation into membrane raft" EXACT []
synonym: "B cell receptor transport into lipid raft" EXACT []
synonym: "BCR translocation into membrane raft" EXACT []
synonym: "BCR transport into membrane raft" EXACT []
is_a: GO:0032595 ! B cell receptor transport within lipid bilayer
is_a: GO:0032596 ! protein transport into membrane raft

[Term]
id: GO:0032598
name: B cell receptor transport into immunological synapse
namespace: biological_process
def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah]
synonym: "B cell receptor translocation into immunological synapse" EXACT []
synonym: "BCR translocation into immunological synapse" EXACT []
synonym: "BCR transport into immunological synapse" EXACT []
is_a: GO:0032597 ! B cell receptor transport into membrane raft

[Term]
id: GO:0032599
name: protein transport out of membrane raft
namespace: biological_process
def: "The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah]
synonym: "protein translocation out of membrane raft" EXACT []
synonym: "protein transport out of lipid raft" EXACT []
synonym: "receptor translocation out of membrane raft" NARROW []
synonym: "receptor transport out of membrane raft" NARROW []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0032600
name: chemokine receptor transport out of membrane raft
namespace: biological_process
def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah]
synonym: "chemokine receptor translocation out of membrane raft" EXACT []
synonym: "chemokine receptor transport out of lipid raft" EXACT []
is_a: GO:0032599 ! protein transport out of membrane raft
is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer

[Term]
id: GO:0032601
name: connective tissue growth factor production
namespace: biological_process
def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CCN2 production" EXACT []
synonym: "CTGF production" EXACT []
synonym: "Fisp12 production" EXACT []
synonym: "Hcs24 production" EXACT []
synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "IGFBP8 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032602
name: chemokine production
namespace: biological_process
alt_id: GO:0042033
alt_id: GO:0050755
alt_id: GO:0090195
def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, ISBN:0198506732, PMID:12183377, Wikipedia:Chemokine]
subset: gocheck_do_not_annotate
synonym: "chemokine anabolism" EXACT []
synonym: "chemokine biosynthesis" EXACT []
synonym: "chemokine biosynthetic process" NARROW []
synonym: "chemokine formation" EXACT []
synonym: "chemokine metabolic process" NARROW []
synonym: "chemokine secretion" NARROW []
synonym: "chemokine synthesis" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032603
name: fractalkine production
namespace: biological_process
alt_id: GO:0050751
alt_id: GO:0050754
alt_id: GO:0050756
def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:12729461]
subset: gocheck_do_not_annotate
synonym: "ABCD-3 production" EXACT []
synonym: "CX3CL1 production" EXACT []
synonym: "fractalkine biosynthetic process" NARROW []
synonym: "fractalkine metabolic process" NARROW []
synonym: "neurotactin production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0032604
name: granulocyte macrophage colony-stimulating factor production
namespace: biological_process
alt_id: GO:0042253
def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, ISBN:0198506732]
subset: gocheck_do_not_annotate
synonym: "GM-CSF production" EXACT [GOC:vk]
synonym: "granulocyte macrophage colony stimulating factor production" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
is_a: GO:0001816 ! cytokine production
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0032605
name: hepatocyte growth factor production
namespace: biological_process
alt_id: GO:0048175
def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:1838014]
subset: gocheck_do_not_annotate
synonym: "hepatocyte growth factor biosynthetic process" NARROW []
synonym: "HGF production" EXACT []
synonym: "scatter factor production" EXACT []
is_a: GO:0001816 ! cytokine production
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0032606
name: type I interferon production
namespace: biological_process
alt_id: GO:0045351
alt_id: GO:0072641
def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "interferon type I production" EXACT []
synonym: "type I IFN production" EXACT [GOC:mah]
synonym: "type I interferon biosynthetic process" NARROW []
synonym: "type I interferon secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032607
name: interferon-alpha production
namespace: biological_process
alt_id: GO:0045349
alt_id: GO:0072642
def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-alpha production" EXACT [GOC:mah]
synonym: "IFNA production" EXACT [GOC:mah]
synonym: "interferon-alpha biosynthetic process" NARROW []
synonym: "interferon-alpha secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032608
name: interferon-beta production
namespace: biological_process
alt_id: GO:0035546
alt_id: GO:0045350
def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-beta production" EXACT []
synonym: "IFNB production" EXACT [GOC:mah]
synonym: "interferon-beta biosynthetic process" NARROW []
synonym: "interferon-beta secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032609
name: type II interferon production
namespace: biological_process
alt_id: GO:0042095
alt_id: GO:0072643
def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
subset: gocheck_do_not_annotate
synonym: "IFNG production" EXACT [GOC:mah]
synonym: "interferon-gamma biosynthetic process" NARROW []
synonym: "interferon-gamma production" EXACT []
synonym: "interferon-gamma secretion" NARROW []
synonym: "type II IFN production" EXACT [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032610
name: interleukin-1 alpha production
namespace: biological_process
alt_id: GO:0050703
alt_id: GO:0050719
def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-1 alpha production" EXACT []
synonym: "interleukin-1 alpha biosynthetic process" NARROW []
synonym: "interleukin-1 alpha secretion" NARROW []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032611
name: interleukin-1 beta production
namespace: biological_process
alt_id: GO:0050702
alt_id: GO:0050720
def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-1 beta production" EXACT []
synonym: "interleukin-1 beta biosynthetic process" NARROW []
synonym: "interleukin-1 beta secretion" NARROW []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032612
name: interleukin-1 production
namespace: biological_process
alt_id: GO:0042222
alt_id: GO:0050701
def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-1 production" EXACT []
synonym: "interleukin-1 biosynthetic process" NARROW []
synonym: "interleukin-1 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032613
name: interleukin-10 production
namespace: biological_process
alt_id: GO:0042091
alt_id: GO:0072608
def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-10 production" EXACT []
synonym: "interleukin-10 biosynthetic process" NARROW []
synonym: "interleukin-10 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032614
name: interleukin-11 production
namespace: biological_process
alt_id: GO:0042230
alt_id: GO:0072609
def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-11 production" EXACT []
synonym: "interleukin-11 biosynthetic process" NARROW []
synonym: "interleukin-11 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032615
name: interleukin-12 production
namespace: biological_process
alt_id: GO:0042090
alt_id: GO:0072610
def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CLMF production" NARROW [GOC:BHF]
synonym: "IL-12 production" EXACT []
synonym: "interleukin-12 biosynthetic process" NARROW []
synonym: "interleukin-12 secretion" NARROW []
synonym: "NKSF production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032616
name: interleukin-13 production
namespace: biological_process
alt_id: GO:0042231
alt_id: GO:0072611
def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-13 production" EXACT []
synonym: "interleukin-13 biosynthetic process" NARROW []
synonym: "interleukin-13 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032617
name: obsolete interleukin-14 production
namespace: biological_process
alt_id: GO:0042232
alt_id: GO:0072612
def: "OBSOLETE. The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
synonym: "IL-14 production" EXACT []
synonym: "interleukin-14 biosynthetic process" NARROW []
synonym: "interleukin-14 secretion" NARROW []
is_obsolete: true

[Term]
id: GO:0032618
name: interleukin-15 production
namespace: biological_process
alt_id: GO:0042233
alt_id: GO:0072613
def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-15 production" EXACT []
synonym: "interleukin-15 biosynthetic process" NARROW []
synonym: "interleukin-15 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032619
name: interleukin-16 production
namespace: biological_process
alt_id: GO:0042234
alt_id: GO:0072614
def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-16 production" EXACT []
synonym: "interleukin-16 biosynthetic process" NARROW []
synonym: "interleukin-16 secretion" NARROW []
synonym: "LCF production" NARROW [GOC:BHF]
synonym: "pro-interleukin-16 production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032620
name: interleukin-17 production
namespace: biological_process
alt_id: GO:0042235
alt_id: GO:0072615
def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, Wikipedia:Interleukin_17]
subset: gocheck_do_not_annotate
synonym: "CTLA-8 production" EXACT [GOC:BHF]
synonym: "Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:BHF]
synonym: "IL-17 production" EXACT []
synonym: "interleukin-17 biosynthetic process" NARROW []
synonym: "interleukin-17 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032621
name: interleukin-18 production
namespace: biological_process
alt_id: GO:0042241
alt_id: GO:0072616
def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IGIF production" EXACT [GOC:BHF]
synonym: "IL-18 production" EXACT []
synonym: "IL1F4 production" NARROW [GOC:BHF]
synonym: "interleukin-18 biosynthetic process" NARROW []
synonym: "interleukin-18 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032622
name: interleukin-19 production
namespace: biological_process
alt_id: GO:0042236
alt_id: GO:0072617
def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-19 production" EXACT []
synonym: "IL-19 secretion" NARROW [GOC:BHF]
synonym: "interleukin-19 biosynthetic process" NARROW []
synonym: "interleukin-19 secretion" NARROW []
synonym: "ZMDA1 secretion" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032623
name: interleukin-2 production
namespace: biological_process
alt_id: GO:0042094
alt_id: GO:0070970
def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-2 production" EXACT []
synonym: "interleukin-2 biosynthetic process" NARROW []
synonym: "interleukin-2 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032624
name: interleukin-20 production
namespace: biological_process
alt_id: GO:0042237
alt_id: GO:0072618
def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-20 production" EXACT []
synonym: "interleukin-20 biosynthetic process" NARROW []
synonym: "interleukin-20 secretion" NARROW []
synonym: "ZCYTO10 production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032625
name: interleukin-21 production
namespace: biological_process
alt_id: GO:0042238
alt_id: GO:0072619
def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-21 production" EXACT []
synonym: "interleukin-21 biosynthetic process" NARROW []
synonym: "interleukin-21 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032626
name: interleukin-22 production
namespace: biological_process
alt_id: GO:0042239
alt_id: GO:0072620
def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-22 production" EXACT []
synonym: "IL22 production" EXACT [GOC:BHF]
synonym: "ILTIF production" EXACT [GOC:BHF]
synonym: "interleukin-22 biosynthetic process" NARROW []
synonym: "interleukin-22 secretion" NARROW []
synonym: "ZCYTO18 production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032627
name: interleukin-23 production
namespace: biological_process
alt_id: GO:0042240
alt_id: GO:0072621
def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-23 production" EXACT []
synonym: "interleukin-23 biosynthetic process" NARROW []
synonym: "interleukin-23 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032628
name: interleukin-24 production
namespace: biological_process
alt_id: GO:0045524
alt_id: GO:0072622
def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-24 production" EXACT []
synonym: "interleukin-24 biosynthetic process" NARROW []
synonym: "interleukin-24 secretion" NARROW []
synonym: "MDA7 production" NARROW [GOC:BHF]
synonym: "ST16 production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032629
name: interleukin-25 production
namespace: biological_process
alt_id: GO:0045525
alt_id: GO:0072623
def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-25 production" EXACT []
synonym: "IL-25 secretion" NARROW [GOC:BHF]
synonym: "IL17E secretion" NARROW [GOC:BHF]
synonym: "interleukin-25 anabolism" NARROW []
synonym: "interleukin-25 biosynthesis" NARROW []
synonym: "interleukin-25 biosynthetic process" NARROW []
synonym: "interleukin-25 formation" NARROW []
synonym: "interleukin-25 secretion" NARROW []
synonym: "interleukin-25 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032630
name: interleukin-26 production
namespace: biological_process
alt_id: GO:0045526
alt_id: GO:0072624
def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "AK155 secretion" NARROW [GOC:BHF]
synonym: "IL-26 production" EXACT []
synonym: "interleukin-26 anabolism" NARROW []
synonym: "interleukin-26 biosynthesis" NARROW []
synonym: "interleukin-26 biosynthetic process" NARROW []
synonym: "interleukin-26 formation" NARROW []
synonym: "interleukin-26 secretion" NARROW []
synonym: "interleukin-26 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032631
name: interleukin-27 production
namespace: biological_process
alt_id: GO:0045527
alt_id: GO:0072625
def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-27 production" EXACT []
synonym: "interleukin-27 biosynthetic process" NARROW []
synonym: "interleukin-27 formation" NARROW []
synonym: "interleukin-27 secretion" NARROW []
synonym: "interleukin-27 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032632
name: interleukin-3 production
namespace: biological_process
alt_id: GO:0042223
alt_id: GO:0072601
def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-3 production" EXACT []
synonym: "interleukin-3 biosynthetic process" NARROW []
synonym: "interleukin-3 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032633
name: interleukin-4 production
namespace: biological_process
alt_id: GO:0042097
alt_id: GO:0042224
alt_id: GO:0072602
def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-4 production" EXACT []
synonym: "interleukin-4 biosynthetic process" NARROW []
synonym: "interleukin-4 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032634
name: interleukin-5 production
namespace: biological_process
alt_id: GO:0042225
alt_id: GO:0072603
def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-5 production" EXACT []
synonym: "interleukin-5 biosynthetic process" NARROW []
synonym: "interleukin-5 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032635
name: interleukin-6 production
namespace: biological_process
alt_id: GO:0042226
alt_id: GO:0072604
def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-6 production" EXACT []
synonym: "interleukin-6 biosynthetic process" NARROW []
synonym: "interleukin-6 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032636
name: interleukin-7 production
namespace: biological_process
alt_id: GO:0042227
alt_id: GO:0072605
def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-7 production" EXACT []
synonym: "interleukin-7 biosynthetic process" NARROW []
synonym: "interleukin-7 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032637
name: interleukin-8 production
namespace: biological_process
alt_id: GO:0042228
alt_id: GO:0072606
def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-8 production" EXACT []
synonym: "interleukin-8 biosynthetic process" NARROW []
synonym: "interleukin-8 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032638
name: interleukin-9 production
namespace: biological_process
alt_id: GO:0042229
alt_id: GO:0072607
def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-9 production" EXACT []
synonym: "interleukin-9 biosynthetic process" NARROW []
synonym: "interleukin-9 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032639
name: TRAIL production
namespace: biological_process
alt_id: GO:0045553
def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9311998]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "TRAIL biosynthetic process" NARROW []
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032640
name: tumor necrosis factor production
namespace: biological_process
alt_id: GO:0042533
alt_id: GO:1990774
def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:mah, PMID:10891884, PMID:15560120]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cachectin production" EXACT []
synonym: "TNF alpha biosynthesis" NARROW []
synonym: "TNF biosynthesis" NARROW []
synonym: "TNF biosynthetic process" NARROW []
synonym: "TNF production" EXACT []
synonym: "TNF-alpha biosynthesis" NARROW []
synonym: "TNF-alpha biosynthetic process" NARROW []
synonym: "TNF-alpha production" RELATED []
synonym: "Tnfa production" RELATED []
synonym: "tumor necrosis factor anabolism" NARROW []
synonym: "tumor necrosis factor biosynthesis" NARROW []
synonym: "tumor necrosis factor biosynthetic process" NARROW []
synonym: "tumor necrosis factor formation" NARROW []
synonym: "tumor necrosis factor secretion" NARROW []
synonym: "tumor necrosis factor synthesis" NARROW []
synonym: "tumor necrosis factor-alpha production" RELATED []
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032641
name: lymphotoxin A production
namespace: biological_process
alt_id: GO:0042109
def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "LTA production" EXACT []
synonym: "lymphotoxin A biosynthetic process" NARROW []
synonym: "lymphotoxin A formation" RELATED []
synonym: "lymphotoxin A synthesis" NARROW []
synonym: "lymphotoxin-alpha production" EXACT []
synonym: "TNF-B production" EXACT []
synonym: "TNF-beta production" EXACT []
synonym: "tumor necrosis factor-beta production" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032642
name: regulation of chemokine production
namespace: biological_process
alt_id: GO:0045073
alt_id: GO:0090196
def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah]
synonym: "regulation of chemokine biosynthetic process" NARROW []
synonym: "regulation of chemokine secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032643
name: regulation of connective tissue growth factor production
namespace: biological_process
alt_id: GO:0045420
def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "regulation of CCN2 production" EXACT []
synonym: "regulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "regulation of CTGF production" EXACT []
synonym: "regulation of Fisp12 production" EXACT []
synonym: "regulation of Hcs24 production" EXACT []
synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "regulation of IGFBP8 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032644
name: regulation of fractalkine production
namespace: biological_process
alt_id: GO:0050752
def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "regulation of CX3CL1 biosynthesis" NARROW []
synonym: "regulation of CX3CL1 production" NARROW []
synonym: "regulation of fractalkine biosynthetic process" NARROW []
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032645
name: regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
alt_id: GO:0045423
def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "regulation of GM-CSF production" EXACT [GOC:vk]
synonym: "regulation of granulocyte macrophage colony stimulating factor production" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032646
name: regulation of hepatocyte growth factor production
namespace: biological_process
alt_id: GO:0048176
def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah, PMID:1838014]
synonym: "regulation of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "regulation of HGF production" EXACT []
synonym: "regulation of scatter factor production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032647
name: regulation of interferon-alpha production
namespace: biological_process
alt_id: GO:0045354
alt_id: GO:1902739
def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383]
synonym: "regulation of interferon-alpha biosynthetic process" NARROW []
synonym: "regulation of interferon-alpha secretion" NARROW []
is_a: GO:0032479 ! regulation of type I interferon production
relationship: regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032648
name: regulation of interferon-beta production
namespace: biological_process
alt_id: GO:0035547
alt_id: GO:0045357
def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383]
synonym: "regulation of IFN-beta production" EXACT []
synonym: "regulation of interferon-beta biosynthetic process" NARROW []
synonym: "regulation of interferon-beta secretion" NARROW []
is_a: GO:0032479 ! regulation of type I interferon production
relationship: regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032649
name: regulation of type II interferon production
namespace: biological_process
alt_id: GO:0045072
alt_id: GO:1902713
def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
synonym: "regulation of interferon-gamma biosynthetic process" NARROW []
synonym: "regulation of interferon-gamma production" EXACT []
synonym: "regulation of interferon-gamma secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032609 ! type II interferon production

[Term]
id: GO:0032650
name: regulation of interleukin-1 alpha production
namespace: biological_process
alt_id: GO:0050705
alt_id: GO:0050721
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "regulation of IL-1 alpha production" EXACT []
synonym: "regulation of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "regulation of interleukin-1 alpha secretion" NARROW []
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032651
name: regulation of interleukin-1 beta production
namespace: biological_process
alt_id: GO:0050706
alt_id: GO:0050722
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "regulation of IL-1 beta production" EXACT []
synonym: "regulation of interleukin-1 beta biosynthetic process" NARROW []
synonym: "regulation of interleukin-1 beta secretion" NARROW []
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032652
name: regulation of interleukin-1 production
namespace: biological_process
alt_id: GO:0045360
alt_id: GO:0050704
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "regulation of IL-1 production" EXACT []
synonym: "regulation of interleukin-1 biosynthetic process" NARROW []
synonym: "regulation of interleukin-1 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032653
name: regulation of interleukin-10 production
namespace: biological_process
alt_id: GO:0045074
alt_id: GO:2001179
def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "regulation of IL-10 production" EXACT []
synonym: "regulation of interleukin-10 biosynthetic process" NARROW []
synonym: "regulation of interleukin-10 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032654
name: regulation of interleukin-11 production
namespace: biological_process
alt_id: GO:0045363
alt_id: GO:0150169
def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137]
synonym: "regulation of IL-11 production" EXACT []
synonym: "regulation of interleukin-11 biosynthetic process" NARROW []
synonym: "regulation of interleukin-11 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032655
name: regulation of interleukin-12 production
namespace: biological_process
alt_id: GO:0045075
alt_id: GO:2001182
def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "regulation of CLMF production" RELATED [GOC:obol]
synonym: "regulation of IL-12 production" EXACT []
synonym: "regulation of interleukin-12 biosynthetic process" NARROW []
synonym: "regulation of interleukin-12 secretion" NARROW []
synonym: "regulation of NKSF production" RELATED [GOC:obol]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032656
name: regulation of interleukin-13 production
namespace: biological_process
alt_id: GO:0045366
alt_id: GO:2000665
def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "regulation of IL-13 production" EXACT []
synonym: "regulation of interleukin-13 biosynthetic process" NARROW []
synonym: "regulation of interleukin-13 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032657
name: obsolete regulation of interleukin-14 production
namespace: biological_process
alt_id: GO:0045369
def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
synonym: "regulation of IL-14 production" EXACT []
synonym: "regulation of interleukin-14 biosynthetic process" NARROW []
is_obsolete: true

[Term]
id: GO:0032658
name: regulation of interleukin-15 production
namespace: biological_process
alt_id: GO:0045372
def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "regulation of IL-15 production" EXACT []
synonym: "regulation of interleukin-15 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032659
name: regulation of interleukin-16 production
namespace: biological_process
alt_id: GO:0045375
def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "regulation of IL-16 production" EXACT []
synonym: "regulation of interleukin-16 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032660
name: regulation of interleukin-17 production
namespace: biological_process
alt_id: GO:0045378
alt_id: GO:1905076
def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511]
synonym: "regulation of CTLA-8 production" EXACT [GOC:TermGenie]
synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT []
synonym: "regulation of IL-17 production" EXACT []
synonym: "regulation of interleukin-17 biosynthetic process" NARROW []
synonym: "regulation of interleukin-17 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032661
name: regulation of interleukin-18 production
namespace: biological_process
alt_id: GO:0045381
alt_id: GO:0150120
def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316]
synonym: "regulation of IL-18 production" EXACT []
synonym: "regulation of interleukin-18 biosynthetic process" NARROW []
synonym: "regulation of interleukin-18 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032662
name: regulation of interleukin-19 production
namespace: biological_process
alt_id: GO:0045384
def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "regulation of IL-19 production" EXACT []
synonym: "regulation of interleukin-19 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032663
name: regulation of interleukin-2 production
namespace: biological_process
alt_id: GO:0045076
alt_id: GO:1900040
def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "regulation of IL-2 production" EXACT []
synonym: "regulation of interleukin-2 biosynthetic process" NARROW []
synonym: "regulation of interleukin-2 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032664
name: regulation of interleukin-20 production
namespace: biological_process
alt_id: GO:0045387
def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "regulation of IL-20 production" EXACT []
synonym: "regulation of interleukin-20 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032665
name: regulation of interleukin-21 production
namespace: biological_process
alt_id: GO:0045390
def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "regulation of IL-21 production" EXACT []
synonym: "regulation of interleukin-21 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032666
name: regulation of interleukin-22 production
namespace: biological_process
alt_id: GO:0045393
def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "regulation of IL-22 production" EXACT []
synonym: "regulation of interleukin-22 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032667
name: regulation of interleukin-23 production
namespace: biological_process
alt_id: GO:0045396
def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "regulation of IL-23 biosynthetic process" EXACT []
synonym: "regulation of IL-23 production" EXACT []
synonym: "regulation of interleukin-23 anabolism" NARROW []
synonym: "regulation of interleukin-23 biosynthesis" NARROW []
synonym: "regulation of interleukin-23 biosynthetic process" NARROW []
synonym: "regulation of interleukin-23 formation" NARROW []
synonym: "regulation of interleukin-23 synthesis" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032668
name: regulation of interleukin-24 production
namespace: biological_process
alt_id: GO:0045528
def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "regulation of IL-24 production" EXACT []
synonym: "regulation of interleukin-24 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032669
name: regulation of interleukin-25 production
namespace: biological_process
alt_id: GO:0045529
alt_id: GO:0150148
def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah, PMID:27901018]
synonym: "regulation of IL-25 production" EXACT []
synonym: "regulation of interleukin-25 biosynthetic process" NARROW []
synonym: "regulation of interleukin-25 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032670
name: regulation of interleukin-26 production
namespace: biological_process
alt_id: GO:0045530
def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "regulation of IL-26 production" EXACT []
synonym: "regulation of interleukin-26 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032671
name: regulation of interleukin-27 production
namespace: biological_process
alt_id: GO:0045531
def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "regulation of IL-27 production" EXACT []
synonym: "regulation of interleukin-27 biosynthetic process" NARROW []
synonym: "regulation of interleukin-27 formation" NARROW []
synonym: "regulation of interleukin-27 synthesis" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032672
name: regulation of interleukin-3 production
namespace: biological_process
alt_id: GO:0045399
def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "regulation of IL-3 production" EXACT []
synonym: "regulation of interleukin-3 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032673
name: regulation of interleukin-4 production
namespace: biological_process
alt_id: GO:0045402
alt_id: GO:0150133
def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524]
synonym: "regulation of IL-4 production" EXACT []
synonym: "regulation of interleukin-4 biosynthetic process" NARROW []
synonym: "regulation of interleukin-4 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032674
name: regulation of interleukin-5 production
namespace: biological_process
alt_id: GO:0045405
alt_id: GO:2000662
def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "regulation of IL-5 production" EXACT []
synonym: "regulation of interleukin-5 biosynthetic process" NARROW []
synonym: "regulation of interleukin-5 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032675
name: regulation of interleukin-6 production
namespace: biological_process
alt_id: GO:0045408
def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "regulation of IL-6 production" EXACT []
synonym: "regulation of interleukin-6 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032676
name: regulation of interleukin-7 production
namespace: biological_process
alt_id: GO:0045411
alt_id: GO:0150112
def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782]
synonym: "regulation of IL-7 production" EXACT []
synonym: "regulation of interleukin-7 biosynthetic process" NARROW []
synonym: "regulation of interleukin-7 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032677
name: regulation of interleukin-8 production
namespace: biological_process
alt_id: GO:0045414
alt_id: GO:2000482
def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "regulation of IL-8 production" EXACT []
synonym: "regulation of interleukin-8 biosynthetic process" NARROW []
synonym: "regulation of interleukin-8 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032678
name: regulation of interleukin-9 production
namespace: biological_process
alt_id: GO:0045417
def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "regulation of IL-9 production" EXACT []
synonym: "regulation of interleukin-9 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032679
name: regulation of TRAIL production
namespace: biological_process
alt_id: GO:0045554
def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah]
synonym: "regulation of TRAIL biosynthetic process" NARROW []
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
relationship: regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032680
name: regulation of tumor necrosis factor production
namespace: biological_process
alt_id: GO:0042534
alt_id: GO:1904467
def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor production." [GOC:mah, PMID:10891884, PMID:15560120]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "regulation of cachectin production" EXACT [GOC:TermGenie]
synonym: "regulation of TNF production" EXACT []
synonym: "regulation of TNF-alpha production" EXACT []
synonym: "regulation of tumor necrosis factor biosynthetic process" NARROW []
synonym: "regulation of tumor necrosis factor secretion" NARROW []
synonym: "regulation of tumor necrosis factor-alpha production" EXACT []
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
relationship: regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032681
name: regulation of lymphotoxin A production
namespace: biological_process
alt_id: GO:0043016
def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "regulation of LTA production" EXACT []
synonym: "regulation of lymphotoxin A biosynthetic process" NARROW []
synonym: "regulation of lymphotoxin-alpha production" EXACT []
synonym: "regulation of TNF-beta production" EXACT []
synonym: "regulation of tumor necrosis factor-beta production" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
relationship: regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032682
name: negative regulation of chemokine production
namespace: biological_process
alt_id: GO:0045079
alt_id: GO:0090198
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah]
synonym: "down regulation of chemokine production" EXACT []
synonym: "down-regulation of chemokine production" EXACT []
synonym: "downregulation of chemokine production" EXACT []
synonym: "inhibition of chemokine production" NARROW []
synonym: "negative regulation of chemokine biosynthetic process" NARROW []
synonym: "negative regulation of chemokine secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032642 ! regulation of chemokine production
relationship: negatively_regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032683
name: negative regulation of connective tissue growth factor production
namespace: biological_process
alt_id: GO:0045421
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "down regulation of connective tissue growth factor production" EXACT []
synonym: "down-regulation of connective tissue growth factor production" EXACT []
synonym: "downregulation of connective tissue growth factor production" EXACT []
synonym: "inhibition of connective tissue growth factor production" NARROW []
synonym: "negative regulation of CCN2 production" EXACT []
synonym: "negative regulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "negative regulation of CTGF production" EXACT []
synonym: "negative regulation of Fisp12 production" EXACT []
synonym: "negative regulation of Hcs24 production" EXACT []
synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "negative regulation of IGFBP8 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032643 ! regulation of connective tissue growth factor production
relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032684
name: negative regulation of fractalkine production
namespace: biological_process
alt_id: GO:0050753
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "down regulation of fractalkine production" EXACT []
synonym: "down-regulation of fractalkine production" EXACT []
synonym: "downregulation of fractalkine production" EXACT []
synonym: "inhibition of fractalkine production" NARROW []
synonym: "negative regulation of CX3CL1 biosynthesis" NARROW []
synonym: "negative regulation of CX3CL1 production" EXACT []
synonym: "negative regulation of fractalkine biosynthetic process" NARROW []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0032682 ! negative regulation of chemokine production
relationship: negatively_regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032685
name: negative regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
alt_id: GO:0045424
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "negative regulation of GM-CSF production" EXACT [GOC:vk]
synonym: "negative regulation of granulocyte macrophage colony stimulating factor production" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032686
name: negative regulation of hepatocyte growth factor production
namespace: biological_process
alt_id: GO:0048178
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah, PMID:1838014]
synonym: "down regulation of hepatocyte growth factor production" EXACT []
synonym: "down-regulation of hepatocyte growth factor production" EXACT []
synonym: "downregulation of hepatocyte growth factor production" EXACT []
synonym: "inhibition of hepatocyte growth factor production" NARROW []
synonym: "negative regulation of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "negative regulation of HGF production" EXACT []
synonym: "negative regulation of scatter factor production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032687
name: negative regulation of interferon-alpha production
namespace: biological_process
alt_id: GO:0045355
alt_id: GO:1902740
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383]
synonym: "down regulation of interferon-alpha production" EXACT []
synonym: "down-regulation of interferon-alpha production" EXACT []
synonym: "downregulation of interferon-alpha production" EXACT []
synonym: "inhibition of interferon-alpha production" NARROW []
synonym: "negative regulation of interferon-alpha biosynthetic process" NARROW []
synonym: "negative regulation of interferon-alpha secretion" NARROW []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032647 ! regulation of interferon-alpha production
relationship: negatively_regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032688
name: negative regulation of interferon-beta production
namespace: biological_process
alt_id: GO:0035548
alt_id: GO:0045358
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383]
synonym: "down regulation of interferon-beta production" EXACT []
synonym: "down-regulation of interferon-beta production" EXACT []
synonym: "downregulation of interferon-beta production" EXACT []
synonym: "inhibition of interferon-beta production" NARROW []
synonym: "negative regulation of IFN-beta production" EXACT []
synonym: "negative regulation of interferon-beta biosynthetic process" NARROW []
synonym: "negative regulation of interferon-beta secretion" NARROW []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032648 ! regulation of interferon-beta production
relationship: negatively_regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032689
name: negative regulation of type II interferon production
namespace: biological_process
alt_id: GO:0045077
alt_id: GO:1902714
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
synonym: "down regulation of interferon-gamma production" EXACT []
synonym: "down-regulation of interferon-gamma production" EXACT []
synonym: "downregulation of interferon-gamma production" EXACT []
synonym: "inhibition of interferon-gamma production" NARROW []
synonym: "negative regulation of interferon-gamma biosynthetic process" NARROW []
synonym: "negative regulation of interferon-gamma production" EXACT []
synonym: "negative regulation of interferon-gamma secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032649 ! regulation of type II interferon production
relationship: negatively_regulates GO:0032609 ! type II interferon production

[Term]
id: GO:0032690
name: negative regulation of interleukin-1 alpha production
namespace: biological_process
alt_id: GO:0050712
alt_id: GO:0050723
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "down regulation of interleukin-1 alpha production" EXACT []
synonym: "down-regulation of interleukin-1 alpha production" EXACT []
synonym: "downregulation of interleukin-1 alpha production" EXACT []
synonym: "inhibition of interleukin-1 alpha production" NARROW []
synonym: "negative regulation of IL-1 alpha production" EXACT []
synonym: "negative regulation of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-1 alpha secretion" NARROW []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032691
name: negative regulation of interleukin-1 beta production
namespace: biological_process
alt_id: GO:0050713
alt_id: GO:0050724
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "down regulation of interleukin-1 beta production" EXACT []
synonym: "down-regulation of interleukin-1 beta production" EXACT []
synonym: "downregulation of interleukin-1 beta production" EXACT []
synonym: "inhibition of interleukin-1 beta production" NARROW []
synonym: "negative regulation of IL-1 beta production" EXACT []
synonym: "negative regulation of interleukin-1 beta biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-1 beta secretion" NARROW []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032692
name: negative regulation of interleukin-1 production
namespace: biological_process
alt_id: GO:0045361
alt_id: GO:0050711
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "down regulation of interleukin-1 production" EXACT []
synonym: "down-regulation of interleukin-1 production" EXACT []
synonym: "downregulation of interleukin-1 production" EXACT []
synonym: "inhibition of interleukin-1 production" NARROW []
synonym: "negative regulation of IL-1 production" EXACT []
synonym: "negative regulation of interleukin-1 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-1 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: negatively_regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032693
name: negative regulation of interleukin-10 production
namespace: biological_process
alt_id: GO:0045081
alt_id: GO:2001180
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "down regulation of interleukin-10 production" EXACT []
synonym: "down-regulation of interleukin-10 production" EXACT []
synonym: "downregulation of interleukin-10 production" EXACT []
synonym: "inhibition of interleukin-10 production" NARROW []
synonym: "negative regulation of IL-10 production" EXACT []
synonym: "negative regulation of interleukin-10 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-10 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032653 ! regulation of interleukin-10 production
relationship: negatively_regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032694
name: negative regulation of interleukin-11 production
namespace: biological_process
alt_id: GO:0045364
alt_id: GO:0150170
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137]
synonym: "down regulation of interleukin-11 production" EXACT []
synonym: "down-regulation of interleukin-11 production" EXACT []
synonym: "downregulation of interleukin-11 production" EXACT []
synonym: "inhibition of interleukin-11 production" NARROW []
synonym: "negative regulation of IL-11 production" EXACT []
synonym: "negative regulation of interleukin-11 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-11 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032654 ! regulation of interleukin-11 production
relationship: negatively_regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032695
name: negative regulation of interleukin-12 production
namespace: biological_process
alt_id: GO:0045083
alt_id: GO:2001183
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "down regulation of interleukin-12 production" EXACT []
synonym: "down-regulation of interleukin-12 production" EXACT []
synonym: "downregulation of interleukin-12 production" EXACT []
synonym: "inhibition of interleukin-12 production" NARROW []
synonym: "negative regulation of CLMF production" RELATED [GOC:obol]
synonym: "negative regulation of IL-12 production" EXACT []
synonym: "negative regulation of interleukin-12 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-12 secretion" NARROW []
synonym: "negative regulation of NKSF production" RELATED [GOC:obol]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032655 ! regulation of interleukin-12 production
relationship: negatively_regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032696
name: negative regulation of interleukin-13 production
namespace: biological_process
alt_id: GO:0045367
alt_id: GO:2000666
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "down regulation of interleukin-13 production" EXACT []
synonym: "down-regulation of interleukin-13 production" EXACT []
synonym: "downregulation of interleukin-13 production" EXACT []
synonym: "inhibition of interleukin-13 production" NARROW []
synonym: "negative regulation of IL-13 production" EXACT []
synonym: "negative regulation of interleukin-13 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-13 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032656 ! regulation of interleukin-13 production
relationship: negatively_regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032697
name: obsolete negative regulation of interleukin-14 production
namespace: biological_process
alt_id: GO:0045370
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
synonym: "down regulation of interleukin-14 production" EXACT []
synonym: "down-regulation of interleukin-14 production" EXACT []
synonym: "downregulation of interleukin-14 production" EXACT []
synonym: "inhibition of interleukin-14 production" NARROW []
synonym: "negative regulation of IL-14 production" EXACT []
synonym: "negative regulation of interleukin-14 biosynthetic process" NARROW []
is_obsolete: true

[Term]
id: GO:0032698
name: negative regulation of interleukin-15 production
namespace: biological_process
alt_id: GO:0045373
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "down regulation of interleukin-15 production" EXACT []
synonym: "down-regulation of interleukin-15 production" EXACT []
synonym: "downregulation of interleukin-15 production" EXACT []
synonym: "inhibition of interleukin-15 production" NARROW []
synonym: "negative regulation of IL-15 production" EXACT []
synonym: "negative regulation of interleukin-15 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032658 ! regulation of interleukin-15 production
relationship: negatively_regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032699
name: negative regulation of interleukin-16 production
namespace: biological_process
alt_id: GO:0045376
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "down regulation of interleukin-16 production" EXACT []
synonym: "down-regulation of interleukin-16 production" EXACT []
synonym: "downregulation of interleukin-16 production" EXACT []
synonym: "inhibition of interleukin-16 production" NARROW []
synonym: "negative regulation of IL-16 production" EXACT []
synonym: "negative regulation of interleukin-16 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032659 ! regulation of interleukin-16 production
relationship: negatively_regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032700
name: negative regulation of interleukin-17 production
namespace: biological_process
alt_id: GO:0045379
alt_id: GO:1905077
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511]
synonym: "down regulation of interleukin-17 production" EXACT []
synonym: "downregulation of interleukin-17 production" EXACT []
synonym: "inhibition of interleukin-17 production" NARROW []
synonym: "negative regulation of CTLA-8 production" NARROW [GOC:TermGenie]
synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of IL-17 production" EXACT []
synonym: "negative regulation of interleukin-17 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-17 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032660 ! regulation of interleukin-17 production
relationship: negatively_regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032701
name: negative regulation of interleukin-18 production
namespace: biological_process
alt_id: GO:0045382
alt_id: GO:0150121
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316]
synonym: "down regulation of interleukin-18 production" EXACT []
synonym: "down-regulation of interleukin-18 production" EXACT []
synonym: "downregulation of interleukin-18 production" EXACT []
synonym: "inhibition of interleukin-18 production" NARROW []
synonym: "negative regulation of IL-18 production" EXACT []
synonym: "negative regulation of interleukin-18 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-18 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032661 ! regulation of interleukin-18 production
relationship: negatively_regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032702
name: negative regulation of interleukin-19 production
namespace: biological_process
alt_id: GO:0045385
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "down regulation of interleukin-19 production" EXACT []
synonym: "down-regulation of interleukin-19 production" EXACT []
synonym: "downregulation of interleukin-19 production" EXACT []
synonym: "inhibition of interleukin-19 production" NARROW []
synonym: "negative regulation of IL-19 production" EXACT []
synonym: "negative regulation of interleukin-19 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032662 ! regulation of interleukin-19 production
relationship: negatively_regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032703
name: negative regulation of interleukin-2 production
namespace: biological_process
alt_id: GO:0045085
alt_id: GO:1900041
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "down regulation of interleukin-2 production" EXACT []
synonym: "down-regulation of interleukin-2 production" EXACT []
synonym: "downregulation of interleukin-2 production" EXACT []
synonym: "inhibition of interleukin-2 production" NARROW []
synonym: "negative regulation of IL-2 production" EXACT []
synonym: "negative regulation of interleukin-2 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-2 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032663 ! regulation of interleukin-2 production
relationship: negatively_regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032704
name: negative regulation of interleukin-20 production
namespace: biological_process
alt_id: GO:0045388
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "down regulation of interleukin-20 production" EXACT []
synonym: "down-regulation of interleukin-20 production" EXACT []
synonym: "downregulation of interleukin-20 production" EXACT []
synonym: "inhibition of interleukin-20 production" NARROW []
synonym: "negative regulation of IL-20 production" EXACT []
synonym: "negative regulation of interleukin-20 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032664 ! regulation of interleukin-20 production
relationship: negatively_regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032705
name: negative regulation of interleukin-21 production
namespace: biological_process
alt_id: GO:0045391
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "down regulation of interleukin-21 production" EXACT []
synonym: "down-regulation of interleukin-21 production" EXACT []
synonym: "downregulation of interleukin-21 production" EXACT []
synonym: "negative regulation of interleukin-21 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032665 ! regulation of interleukin-21 production
relationship: negatively_regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032706
name: negative regulation of interleukin-22 production
namespace: biological_process
alt_id: GO:0045394
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "down regulation of interleukin-22 production" EXACT []
synonym: "down-regulation of interleukin-22 production" EXACT []
synonym: "downregulation of interleukin-22 production" EXACT []
synonym: "inhibition of interleukin-22 production" NARROW []
synonym: "negative regulation of IL-22 production" EXACT []
synonym: "negative regulation of interleukin-22 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032666 ! regulation of interleukin-22 production
relationship: negatively_regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032707
name: negative regulation of interleukin-23 production
namespace: biological_process
alt_id: GO:0045397
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "down regulation of interleukin-23 production" EXACT []
synonym: "down-regulation of interleukin-23 production" EXACT []
synonym: "downregulation of interleukin-23 production" EXACT []
synonym: "inhibition of interleukin-23 production" NARROW []
synonym: "negative regulation of IL-23 production" EXACT []
synonym: "negative regulation of interleukin-23 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032667 ! regulation of interleukin-23 production
relationship: negatively_regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032708
name: negative regulation of interleukin-24 production
namespace: biological_process
alt_id: GO:0045532
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "down regulation of interleukin-24 production" EXACT []
synonym: "down-regulation of interleukin-24 production" EXACT []
synonym: "downregulation of interleukin-24 production" EXACT []
synonym: "inhibition of interleukin-24 production" NARROW []
synonym: "negative regulation of IL-24 production" EXACT []
synonym: "negative regulation of interleukin-24 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032668 ! regulation of interleukin-24 production
relationship: negatively_regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032709
name: negative regulation of interleukin-25 production
namespace: biological_process
alt_id: GO:0045533
alt_id: GO:0150149
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "down regulation of interleukin-25 production" EXACT []
synonym: "down-regulation of interleukin-25 production" EXACT []
synonym: "downregulation of interleukin-25 production" EXACT []
synonym: "inhibition of interleukin-25 production" NARROW []
synonym: "negative regulation of IL-25 production" EXACT []
synonym: "negative regulation of interleukin-25 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-25 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032669 ! regulation of interleukin-25 production
relationship: negatively_regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032710
name: negative regulation of interleukin-26 production
namespace: biological_process
alt_id: GO:0045534
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "down regulation of interleukin-26 production" EXACT []
synonym: "down-regulation of interleukin-26 production" EXACT []
synonym: "downregulation of interleukin-26 production" EXACT []
synonym: "inhibition of interleukin-26 production" NARROW []
synonym: "negative regulation of IL-26 production" EXACT []
synonym: "negative regulation of interleukin-26 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032670 ! regulation of interleukin-26 production
relationship: negatively_regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032711
name: negative regulation of interleukin-27 production
namespace: biological_process
alt_id: GO:0045535
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "down regulation of interleukin-27 production" EXACT []
synonym: "down-regulation of interleukin-27 production" EXACT []
synonym: "downregulation of interleukin-27 production" EXACT []
synonym: "inhibition of interleukin-27 production" NARROW []
synonym: "negative regulation of IL-27 production" EXACT []
synonym: "negative regulation of interleukin-27 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032671 ! regulation of interleukin-27 production
relationship: negatively_regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032712
name: negative regulation of interleukin-3 production
namespace: biological_process
alt_id: GO:0045400
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "down regulation of interleukin-3 production" EXACT []
synonym: "down-regulation of interleukin-3 production" EXACT []
synonym: "downregulation of interleukin-3 production" EXACT []
synonym: "inhibition of interleukin-3 production" NARROW []
synonym: "negative regulation of IL-3 production" EXACT []
synonym: "negative regulation of interleukin-3 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032672 ! regulation of interleukin-3 production
relationship: negatively_regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032713
name: negative regulation of interleukin-4 production
namespace: biological_process
alt_id: GO:0045403
alt_id: GO:0150134
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524]
synonym: "down regulation of interleukin-4 production" EXACT []
synonym: "down-regulation of interleukin-4 production" EXACT []
synonym: "downregulation of interleukin-4 production" EXACT []
synonym: "inhibition of interleukin-4 production" NARROW []
synonym: "negative regulation of IL-4 production" EXACT []
synonym: "negative regulation of interleukin-4 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-4 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032673 ! regulation of interleukin-4 production
relationship: negatively_regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032714
name: negative regulation of interleukin-5 production
namespace: biological_process
alt_id: GO:0045406
alt_id: GO:2000663
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "down regulation of interleukin-5 production" EXACT []
synonym: "down-regulation of interleukin-5 production" EXACT []
synonym: "downregulation of interleukin-5 production" EXACT []
synonym: "inhibition of interleukin-5 production" NARROW []
synonym: "negative regulation of IL-5 production" EXACT []
synonym: "negative regulation of interleukin-5 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-5 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032674 ! regulation of interleukin-5 production
relationship: negatively_regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032715
name: negative regulation of interleukin-6 production
namespace: biological_process
alt_id: GO:0045409
alt_id: GO:1900165
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "down regulation of interleukin-6 production" EXACT []
synonym: "down-regulation of interleukin-6 production" EXACT []
synonym: "downregulation of interleukin-6 production" EXACT []
synonym: "inhibition of interleukin-6 production" NARROW []
synonym: "negative regulation of IL-6 production" EXACT []
synonym: "negative regulation of interleukin-6 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-6 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032675 ! regulation of interleukin-6 production
relationship: negatively_regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032716
name: negative regulation of interleukin-7 production
namespace: biological_process
alt_id: GO:0045412
alt_id: GO:0150113
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782]
synonym: "down regulation of interleukin-7 production" EXACT []
synonym: "down-regulation of interleukin-7 production" EXACT []
synonym: "downregulation of interleukin-7 production" EXACT []
synonym: "inhibition of interleukin-7 production" NARROW []
synonym: "negative regulation of IL-7 production" EXACT []
synonym: "negative regulation of interleukin-7 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-7 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032676 ! regulation of interleukin-7 production
relationship: negatively_regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032717
name: negative regulation of interleukin-8 production
namespace: biological_process
alt_id: GO:0045415
alt_id: GO:2000483
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "down regulation of interleukin-8 production" EXACT []
synonym: "down-regulation of interleukin-8 production" EXACT []
synonym: "downregulation of interleukin-8 production" EXACT []
synonym: "inhibition of interleukin-8 production" NARROW []
synonym: "negative regulation of IL-8 production" EXACT []
synonym: "negative regulation of interleukin-8 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-8 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032677 ! regulation of interleukin-8 production
relationship: negatively_regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032718
name: negative regulation of interleukin-9 production
namespace: biological_process
alt_id: GO:0045418
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "down regulation of interleukin-9 production" EXACT []
synonym: "down-regulation of interleukin-9 production" EXACT []
synonym: "downregulation of interleukin-9 production" EXACT []
synonym: "inhibition of interleukin-9 production" NARROW []
synonym: "negative regulation of IL-9 production" EXACT []
synonym: "negative regulation of interleukin-9 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032678 ! regulation of interleukin-9 production
relationship: negatively_regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032719
name: negative regulation of TRAIL production
namespace: biological_process
alt_id: GO:0045555
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah]
synonym: "down regulation of TRAIL production" EXACT []
synonym: "down-regulation of TRAIL production" EXACT []
synonym: "downregulation of TRAIL production" EXACT []
synonym: "inhibition of TRAIL production" NARROW []
synonym: "negative regulation of TRAIL biosynthetic process" NARROW []
is_a: GO:0032679 ! regulation of TRAIL production
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
relationship: negatively_regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032720
name: negative regulation of tumor necrosis factor production
namespace: biological_process
alt_id: GO:0042536
alt_id: GO:1904468
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah, PMID:10891884, PMID:15560120]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "down regulation of tumor necrosis factor production" EXACT []
synonym: "down-regulation of tumor necrosis factor production" EXACT []
synonym: "downregulation of tumor necrosis factor production" EXACT []
synonym: "inhibition of cachectin production" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor production" NARROW []
synonym: "negative regulation of tumor necrosis factor biosynthetic process" NARROW []
synonym: "negative regulation of tumor necrosis factor secretion" NARROW []
synonym: "negative regulation TNF production" EXACT []
synonym: "negative regulation TNF-alpha production" EXACT []
synonym: "negative regulation tumor necrosis factor-alpha production" EXACT []
is_a: GO:0032680 ! regulation of tumor necrosis factor production
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032721
name: negative regulation of lymphotoxin A production
namespace: biological_process
alt_id: GO:0043018
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "down regulation of lymphotoxin A production" EXACT []
synonym: "down-regulation of lymphotoxin A production" EXACT []
synonym: "downregulation of lymphotoxin A production" EXACT []
synonym: "inhibition of lymphotoxin A production" NARROW []
synonym: "negative regulation of LTA production" EXACT []
synonym: "negative regulation of lymphotoxin A biosynthetic process" NARROW []
synonym: "negative regulation of lymphotoxin-alpha production" EXACT []
synonym: "negative regulation of TNF-beta production" EXACT []
synonym: "negative regulation of tumor necrosis factor-beta production" EXACT []
is_a: GO:0032681 ! regulation of lymphotoxin A production
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
relationship: negatively_regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032722
name: positive regulation of chemokine production
namespace: biological_process
alt_id: GO:0045080
alt_id: GO:0090197
def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah]
synonym: "activation of chemokine production" NARROW []
synonym: "positive regulation of chemokine biosynthetic process" NARROW []
synonym: "positive regulation of chemokine secretion" NARROW []
synonym: "stimulation of chemokine production" NARROW []
synonym: "up regulation of chemokine production" EXACT []
synonym: "up-regulation of chemokine production" EXACT []
synonym: "upregulation of chemokine production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032642 ! regulation of chemokine production
relationship: positively_regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032723
name: positive regulation of connective tissue growth factor production
namespace: biological_process
alt_id: GO:0045422
def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "activation of connective tissue growth factor production" NARROW []
synonym: "positive regulation of CCN2 production" EXACT []
synonym: "positive regulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "positive regulation of CTGF production" EXACT []
synonym: "positive regulation of Fisp12 production" EXACT []
synonym: "positive regulation of Hcs24 production" EXACT []
synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "positive regulation of IGFBP8 production" EXACT []
synonym: "stimulation of connective tissue growth factor production" NARROW []
synonym: "up regulation of connective tissue growth factor production" EXACT []
synonym: "up-regulation of connective tissue growth factor production" EXACT []
synonym: "upregulation of connective tissue growth factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032643 ! regulation of connective tissue growth factor production
relationship: positively_regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032724
name: positive regulation of fractalkine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "activation of fractalkine production" NARROW []
synonym: "stimulation of fractalkine production" NARROW []
synonym: "up regulation of fractalkine production" EXACT []
synonym: "up-regulation of fractalkine production" EXACT []
synonym: "upregulation of fractalkine production" EXACT []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0032722 ! positive regulation of chemokine production
relationship: positively_regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032725
name: positive regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
alt_id: GO:0045425
def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "positive regulation of GM-CSF production" EXACT [GOC:vk]
synonym: "positive regulation of granulocyte macrophage colony stimulating factor production" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032726
name: positive regulation of hepatocyte growth factor production
namespace: biological_process
alt_id: GO:0048177
def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah, PMID:1838014]
synonym: "activation of hepatocyte growth factor production" NARROW []
synonym: "positive regulation of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "positive regulation of HGF production" EXACT []
synonym: "positive regulation of scatter factor production" EXACT []
synonym: "stimulation of hepatocyte growth factor production" NARROW []
synonym: "up regulation of hepatocyte growth factor production" EXACT []
synonym: "up-regulation of hepatocyte growth factor production" EXACT []
synonym: "upregulation of hepatocyte growth factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032727
name: positive regulation of interferon-alpha production
namespace: biological_process
alt_id: GO:0045356
alt_id: GO:1902741
def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383]
synonym: "activation of interferon-alpha production" NARROW []
synonym: "positive regulation of interferon-alpha biosynthetic process" NARROW []
synonym: "positive regulation of interferon-alpha secretion" NARROW []
synonym: "stimulation of interferon-alpha production" NARROW []
synonym: "up regulation of interferon-alpha production" EXACT []
synonym: "up-regulation of interferon-alpha production" EXACT []
synonym: "upregulation of interferon-alpha production" EXACT []
is_a: GO:0032481 ! positive regulation of type I interferon production
is_a: GO:0032647 ! regulation of interferon-alpha production
relationship: positively_regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032728
name: positive regulation of interferon-beta production
namespace: biological_process
alt_id: GO:0035549
alt_id: GO:0045359
def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383]
synonym: "activation of interferon-beta production" NARROW []
synonym: "positive regulation of IFN-beta production" EXACT []
synonym: "positive regulation of interferon-beta biosynthetic process" NARROW []
synonym: "positive regulation of interferon-beta secretion" NARROW []
synonym: "stimulation of interferon-beta production" NARROW []
synonym: "up regulation of interferon-beta production" EXACT []
synonym: "up-regulation of interferon-beta production" EXACT []
synonym: "upregulation of interferon-beta production" EXACT []
is_a: GO:0032481 ! positive regulation of type I interferon production
is_a: GO:0032648 ! regulation of interferon-beta production
relationship: positively_regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032729
name: positive regulation of type II interferon production
namespace: biological_process
alt_id: GO:0045078
alt_id: GO:1902715
def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
synonym: "activation of interferon-gamma production" NARROW []
synonym: "positive regulation of interferon-gamma biosynthetic process" NARROW []
synonym: "positive regulation of interferon-gamma production" EXACT []
synonym: "positive regulation of interferon-gamma secretion" NARROW []
synonym: "stimulation of interferon-gamma production" NARROW []
synonym: "up regulation of interferon-gamma production" EXACT []
synonym: "up-regulation of interferon-gamma production" EXACT []
synonym: "upregulation of interferon-gamma production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032649 ! regulation of type II interferon production
relationship: positively_regulates GO:0032609 ! type II interferon production

[Term]
id: GO:0032730
name: positive regulation of interleukin-1 alpha production
namespace: biological_process
alt_id: GO:0050717
alt_id: GO:0050726
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "activation of interleukin-1 alpha production" NARROW []
synonym: "positive regulation of IL-1 alpha production" EXACT []
synonym: "positive regulation of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-1 alpha secretion" NARROW []
synonym: "stimulation of interleukin-1 alpha production" NARROW []
synonym: "up regulation of interleukin-1 alpha production" EXACT []
synonym: "up-regulation of interleukin-1 alpha production" EXACT []
synonym: "upregulation of interleukin-1 alpha production" EXACT []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0032732 ! positive regulation of interleukin-1 production
relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032731
name: positive regulation of interleukin-1 beta production
namespace: biological_process
alt_id: GO:0050718
alt_id: GO:0050725
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "activation of interleukin-1 beta production" NARROW []
synonym: "positive regulation of IL-1 beta production" EXACT []
synonym: "positive regulation of interleukin-1 beta biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-1 beta secretion" NARROW []
synonym: "stimulation of interleukin-1 beta production" NARROW []
synonym: "up regulation of interleukin-1 beta production" EXACT []
synonym: "up-regulation of interleukin-1 beta production" EXACT []
synonym: "upregulation of interleukin-1 beta production" EXACT []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0032732 ! positive regulation of interleukin-1 production
relationship: positively_regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032732
name: positive regulation of interleukin-1 production
namespace: biological_process
alt_id: GO:0045362
alt_id: GO:0050716
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "activation of interleukin-1 production" NARROW []
synonym: "positive regulation of IL-1 production" EXACT []
synonym: "positive regulation of interleukin-1 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-1 secretion" NARROW []
synonym: "stimulation of interleukin-1 production" NARROW []
synonym: "up regulation of interleukin-1 production" EXACT []
synonym: "up-regulation of interleukin-1 production" EXACT []
synonym: "upregulation of interleukin-1 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: positively_regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032733
name: positive regulation of interleukin-10 production
namespace: biological_process
alt_id: GO:0045082
alt_id: GO:2001181
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "activation of interleukin-10 production" NARROW []
synonym: "positive regulation of IL-10 production" EXACT []
synonym: "positive regulation of interleukin-10 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-10 secretion" NARROW []
synonym: "stimulation of interleukin-10 production" NARROW []
synonym: "up regulation of interleukin-10 production" EXACT []
synonym: "up-regulation of interleukin-10 production" EXACT []
synonym: "upregulation of interleukin-10 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032653 ! regulation of interleukin-10 production
relationship: positively_regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032734
name: positive regulation of interleukin-11 production
namespace: biological_process
alt_id: GO:0045365
alt_id: GO:0150171
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "activation of interleukin-11 production" NARROW []
synonym: "positive regulation of IL-11 production" EXACT []
synonym: "positive regulation of interleukin-11 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-11 secretion" NARROW []
synonym: "stimulation of interleukin-11 production" NARROW []
synonym: "up regulation of interleukin-11 production" EXACT []
synonym: "up-regulation of interleukin-11 production" EXACT []
synonym: "upregulation of interleukin-11 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032654 ! regulation of interleukin-11 production
relationship: positively_regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032735
name: positive regulation of interleukin-12 production
namespace: biological_process
alt_id: GO:0045084
alt_id: GO:2001184
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "activation of interleukin-12 production" NARROW []
synonym: "positive regulation of CLMF production" RELATED [GOC:obol]
synonym: "positive regulation of IL-12 production" EXACT []
synonym: "positive regulation of interleukin-12 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-12 secretion" NARROW []
synonym: "positive regulation of NKSF production" RELATED [GOC:obol]
synonym: "stimulation of interleukin-12 production" NARROW []
synonym: "up regulation of interleukin-12 production" EXACT []
synonym: "up-regulation of interleukin-12 production" EXACT []
synonym: "upregulation of interleukin-12 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032655 ! regulation of interleukin-12 production
relationship: positively_regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032736
name: positive regulation of interleukin-13 production
namespace: biological_process
alt_id: GO:0045368
alt_id: GO:2000667
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "activation of interleukin-13 production" NARROW []
synonym: "positive regulation of IL-13 production" EXACT []
synonym: "positive regulation of interleukin-13 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-13 secretion" NARROW []
synonym: "stimulation of interleukin-13 production" NARROW []
synonym: "up regulation of interleukin-13 production" EXACT []
synonym: "up-regulation of interleukin-13 production" EXACT []
synonym: "upregulation of interleukin-13 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032656 ! regulation of interleukin-13 production
relationship: positively_regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032737
name: obsolete positive regulation of interleukin-14 production
namespace: biological_process
alt_id: GO:0045371
def: "OBSOLETE. Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
synonym: "activation of interleukin-14 production" NARROW []
synonym: "positive regulation of IL-14 production" EXACT []
synonym: "positive regulation of interleukin-14 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-14 production" NARROW []
synonym: "up regulation of interleukin-14 production" EXACT []
synonym: "up-regulation of interleukin-14 production" EXACT []
synonym: "upregulation of interleukin-14 production" EXACT []
is_obsolete: true

[Term]
id: GO:0032738
name: positive regulation of interleukin-15 production
namespace: biological_process
alt_id: GO:0045374
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "activation of interleukin-15 production" NARROW []
synonym: "positive regulation of IL-15 production" EXACT []
synonym: "positive regulation of interleukin-15 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-15 production" NARROW []
synonym: "up regulation of interleukin-15 production" EXACT []
synonym: "up-regulation of interleukin-15 production" EXACT []
synonym: "upregulation of interleukin-15 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032658 ! regulation of interleukin-15 production
relationship: positively_regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032739
name: positive regulation of interleukin-16 production
namespace: biological_process
alt_id: GO:0045377
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "activation of interleukin-16 production" NARROW []
synonym: "positive regulation of IL-16 production" EXACT []
synonym: "positive regulation of interleukin-16 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-16 production" NARROW []
synonym: "up regulation of interleukin-16 production" EXACT []
synonym: "up-regulation of interleukin-16 production" EXACT []
synonym: "upregulation of interleukin-16 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032659 ! regulation of interleukin-16 production
relationship: positively_regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032740
name: positive regulation of interleukin-17 production
namespace: biological_process
alt_id: GO:0045380
alt_id: GO:1905078
def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511]
synonym: "activation of interleukin-17 production" NARROW []
synonym: "positive regulation of CTLA-8 production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:TermGenie]
synonym: "positive regulation of IL-17 production" EXACT []
synonym: "positive regulation of interleukin-17 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-17 secretion" NARROW []
synonym: "stimulation of interleukin-17 production" NARROW []
synonym: "up regulation of interleukin-17 production" EXACT []
synonym: "up-regulation of interleukin-17 production" EXACT []
synonym: "upregulation of interleukin-17 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032660 ! regulation of interleukin-17 production
relationship: positively_regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032741
name: positive regulation of interleukin-18 production
namespace: biological_process
alt_id: GO:0045383
alt_id: GO:0150122
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "activation of interleukin-18 production" NARROW []
synonym: "positive regulation of IL-18 production" EXACT []
synonym: "positive regulation of interleukin-18 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-18 secretion" NARROW []
synonym: "stimulation of interleukin-18 production" NARROW []
synonym: "up regulation of interleukin-18 production" EXACT []
synonym: "up-regulation of interleukin-18 production" EXACT []
synonym: "upregulation of interleukin-18 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032661 ! regulation of interleukin-18 production
relationship: positively_regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032742
name: positive regulation of interleukin-19 production
namespace: biological_process
alt_id: GO:0045386
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "activation of interleukin-19 production" NARROW []
synonym: "positive regulation of IL-19 production" EXACT []
synonym: "positive regulation of interleukin-19 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-19 production" NARROW []
synonym: "up regulation of interleukin-19 production" EXACT []
synonym: "up-regulation of interleukin-19 production" EXACT []
synonym: "upregulation of interleukin-19 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032662 ! regulation of interleukin-19 production
relationship: positively_regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032743
name: positive regulation of interleukin-2 production
namespace: biological_process
alt_id: GO:0045086
alt_id: GO:1900042
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "activation of interleukin-2 production" NARROW []
synonym: "positive regulation of IL-2 production" EXACT []
synonym: "positive regulation of interleukin-2 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-2 secretion" NARROW []
synonym: "stimulation of interleukin-2 production" NARROW []
synonym: "up regulation of interleukin-2 production" EXACT []
synonym: "up-regulation of interleukin-2 production" EXACT []
synonym: "upregulation of interleukin-2 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032663 ! regulation of interleukin-2 production
relationship: positively_regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032744
name: positive regulation of interleukin-20 production
namespace: biological_process
alt_id: GO:0045389
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "activation of interleukin-20 production" NARROW []
synonym: "positive regulation of IL-20 production" EXACT []
synonym: "positive regulation of interleukin-20 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-20 production" NARROW []
synonym: "up regulation of interleukin-20 production" EXACT []
synonym: "up-regulation of interleukin-20 production" EXACT []
synonym: "upregulation of interleukin-20 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032664 ! regulation of interleukin-20 production
relationship: positively_regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032745
name: positive regulation of interleukin-21 production
namespace: biological_process
alt_id: GO:0045392
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "activation of interleukin-21 production" NARROW []
synonym: "positive regulation of IL-21 production" EXACT []
synonym: "positive regulation of interleukin-21 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-21 production" NARROW []
synonym: "up regulation of interleukin-21 production" EXACT []
synonym: "up-regulation of interleukin-21 production" EXACT []
synonym: "upregulation of interleukin-21 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032665 ! regulation of interleukin-21 production
relationship: positively_regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032746
name: positive regulation of interleukin-22 production
namespace: biological_process
alt_id: GO:0045395
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "activation of interleukin-22 production" NARROW []
synonym: "positive regulation of IL-22 production" EXACT []
synonym: "positive regulation of interleukin-22 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-22 production" NARROW []
synonym: "up regulation of interleukin-22 production" EXACT []
synonym: "up-regulation of interleukin-22 production" EXACT []
synonym: "upregulation of interleukin-22 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032666 ! regulation of interleukin-22 production
relationship: positively_regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032747
name: positive regulation of interleukin-23 production
namespace: biological_process
alt_id: GO:0045398
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "activation of interleukin-23 production" NARROW []
synonym: "positive regulation of IL-23 production" EXACT []
synonym: "positive regulation of interleukin-23 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-23 production" NARROW []
synonym: "up regulation of interleukin-23 production" EXACT []
synonym: "up-regulation of interleukin-23 production" EXACT []
synonym: "upregulation of interleukin-23 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032667 ! regulation of interleukin-23 production
relationship: positively_regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032748
name: positive regulation of interleukin-24 production
namespace: biological_process
alt_id: GO:0045536
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "activation of interleukin-24 production" NARROW []
synonym: "positive regulation of IL-24 production" EXACT []
synonym: "positive regulation of interleukin-24 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-24 production" NARROW []
synonym: "up regulation of interleukin-24 production" EXACT []
synonym: "up-regulation of interleukin-24 production" EXACT []
synonym: "upregulation of interleukin-24 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032668 ! regulation of interleukin-24 production
relationship: positively_regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032749
name: positive regulation of interleukin-25 production
namespace: biological_process
alt_id: GO:0045537
alt_id: GO:0150150
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "activation of interleukin-25 production" NARROW []
synonym: "positive regulation of IL-25 production" EXACT []
synonym: "positive regulation of interleukin-25 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-25 secretion" NARROW []
synonym: "stimulation of interleukin-25 production" NARROW []
synonym: "up regulation of interleukin-25 production" EXACT []
synonym: "up-regulation of interleukin-25 production" EXACT []
synonym: "upregulation of interleukin-25 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032669 ! regulation of interleukin-25 production
relationship: positively_regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032750
name: positive regulation of interleukin-26 production
namespace: biological_process
alt_id: GO:0045538
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "activation of interleukin-26 production" NARROW []
synonym: "positive regulation of IL-26 production" EXACT []
synonym: "positive regulation of interleukin-26 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-26 production" NARROW []
synonym: "up regulation of interleukin-26 production" EXACT []
synonym: "up-regulation of interleukin-26 production" EXACT []
synonym: "upregulation of interleukin-26 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032670 ! regulation of interleukin-26 production
relationship: positively_regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032751
name: positive regulation of interleukin-27 production
namespace: biological_process
alt_id: GO:0045539
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "activation of interleukin-27 production" NARROW []
synonym: "positive regulation of IL-27 production" EXACT []
synonym: "positive regulation of interleukin-27 anabolism" NARROW []
synonym: "positive regulation of interleukin-27 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-27 production" NARROW []
synonym: "up regulation of interleukin-27 production" EXACT []
synonym: "up-regulation of interleukin-27 production" EXACT []
synonym: "upregulation of interleukin-27 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032671 ! regulation of interleukin-27 production
relationship: positively_regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032752
name: positive regulation of interleukin-3 production
namespace: biological_process
alt_id: GO:0045401
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "activation of interleukin-3 production" NARROW []
synonym: "positive regulation of IL-3 production" EXACT []
synonym: "positive regulation of interleukin-3 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-3 production" NARROW []
synonym: "up regulation of interleukin-3 production" EXACT []
synonym: "up-regulation of interleukin-3 production" EXACT []
synonym: "upregulation of interleukin-3 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032672 ! regulation of interleukin-3 production
relationship: positively_regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032753
name: positive regulation of interleukin-4 production
namespace: biological_process
alt_id: GO:0045404
alt_id: GO:0150135
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "activation of interleukin-4 production" NARROW []
synonym: "positive regulation of IL-4 production" EXACT []
synonym: "positive regulation of interleukin-4 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-4 secretion" NARROW []
synonym: "stimulation of interleukin-4 production" NARROW []
synonym: "up regulation of interleukin-4 production" EXACT []
synonym: "up-regulation of interleukin-4 production" EXACT []
synonym: "upregulation of interleukin-4 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032673 ! regulation of interleukin-4 production
relationship: positively_regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032754
name: positive regulation of interleukin-5 production
namespace: biological_process
alt_id: GO:0045407
alt_id: GO:2000664
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "activation of interleukin-5 production" NARROW []
synonym: "positive regulation of IL-5 production" EXACT []
synonym: "positive regulation of interleukin-5 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-5 secretion" NARROW []
synonym: "stimulation of interleukin-5 production" NARROW []
synonym: "up regulation of interleukin-5 production" EXACT []
synonym: "up-regulation of interleukin-5 production" EXACT []
synonym: "upregulation of interleukin-5 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032674 ! regulation of interleukin-5 production
relationship: positively_regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032755
name: positive regulation of interleukin-6 production
namespace: biological_process
alt_id: GO:0045410
alt_id: GO:2000778
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "activation of interleukin-6 production" NARROW []
synonym: "positive regulation of IL-6 production" EXACT []
synonym: "positive regulation of interleukin-6 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-6 secretion" NARROW []
synonym: "stimulation of interleukin-6 production" NARROW []
synonym: "up regulation of interleukin-6 production" EXACT []
synonym: "up-regulation of interleukin-6 production" EXACT []
synonym: "upregulation of interleukin-6 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032675 ! regulation of interleukin-6 production
relationship: positively_regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032756
name: positive regulation of interleukin-7 production
namespace: biological_process
alt_id: GO:0045413
alt_id: GO:0150114
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "activation of interleukin-7 production" NARROW []
synonym: "positive regulation of IL-7 production" EXACT []
synonym: "positive regulation of interleukin-7 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-7 secretion" NARROW []
synonym: "stimulation of interleukin-7 production" NARROW []
synonym: "up regulation of interleukin-7 production" EXACT []
synonym: "up-regulation of interleukin-7 production" EXACT []
synonym: "upregulation of interleukin-7 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032676 ! regulation of interleukin-7 production
relationship: positively_regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032757
name: positive regulation of interleukin-8 production
namespace: biological_process
alt_id: GO:0045416
alt_id: GO:2000484
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "activation of interleukin-8 production" NARROW []
synonym: "positive regulation of IL-8 production" EXACT []
synonym: "positive regulation of interleukin-8 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-8 secretion" NARROW []
synonym: "stimulation of interleukin-8 production" NARROW []
synonym: "up regulation of interleukin-8 production" EXACT []
synonym: "up-regulation of interleukin-8 production" EXACT []
synonym: "upregulation of interleukin-8 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032677 ! regulation of interleukin-8 production
relationship: positively_regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032758
name: positive regulation of interleukin-9 production
namespace: biological_process
alt_id: GO:0045419
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "activation of interleukin-9 production" NARROW []
synonym: "positive regulation of IL-9 production" EXACT []
synonym: "positive regulation of interleukin-9 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-9 production" NARROW []
synonym: "up regulation of interleukin-9 production" EXACT []
synonym: "up-regulation of interleukin-9 production" EXACT []
synonym: "upregulation of interleukin-9 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032678 ! regulation of interleukin-9 production
relationship: positively_regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032759
name: positive regulation of TRAIL production
namespace: biological_process
alt_id: GO:0045556
def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah]
synonym: "activation of TRAIL production" NARROW []
synonym: "positive regulation of TRAIL biosynthetic process" NARROW []
synonym: "stimulation of TRAIL production" NARROW []
synonym: "up regulation of TRAIL production" EXACT []
synonym: "up-regulation of TRAIL production" EXACT []
synonym: "upregulation of TRAIL production" EXACT []
is_a: GO:0032679 ! regulation of TRAIL production
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
relationship: positively_regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032760
name: positive regulation of tumor necrosis factor production
namespace: biological_process
alt_id: GO:0042535
alt_id: GO:1904469
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production." [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "activation of tumor necrosis factor production" NARROW []
synonym: "positive regulation of cachectin secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of TNF production" EXACT []
synonym: "positive regulation of TNF secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of TNF-alpha production" EXACT []
synonym: "positive regulation of tumor necrosis factor biosynthesis" NARROW []
synonym: "positive regulation of tumor necrosis factor biosynthetic process" NARROW []
synonym: "positive regulation of tumor necrosis factor formation" NARROW []
synonym: "positive regulation of tumor necrosis factor secretion" NARROW []
synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT []
synonym: "stimulation of tumor necrosis factor production" NARROW []
synonym: "up regulation of tumor necrosis factor production" EXACT []
synonym: "up-regulation of tumor necrosis factor production" EXACT []
synonym: "upregulation of tumor necrosis factor production" EXACT []
is_a: GO:0032680 ! regulation of tumor necrosis factor production
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
relationship: positively_regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032761
name: positive regulation of lymphotoxin A production
namespace: biological_process
alt_id: GO:0043017
def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "activation of lymphotoxin A production" NARROW []
synonym: "positive regulation of LTA production" EXACT []
synonym: "positive regulation of lymphotoxin A biosynthetic process" NARROW []
synonym: "positive regulation of lymphotoxin-alpha production" EXACT []
synonym: "positive regulation of TNF-beta production" EXACT []
synonym: "positive regulation of tumor necrosis factor-beta production" EXACT []
synonym: "stimulation of lymphotoxin A production" NARROW []
synonym: "up regulation of lymphotoxin A production" EXACT []
synonym: "up-regulation of lymphotoxin A production" EXACT []
synonym: "upregulation of lymphotoxin A production" EXACT []
is_a: GO:0032681 ! regulation of lymphotoxin A production
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
relationship: positively_regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032762
name: mast cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0032763
name: regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
relationship: regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032764
name: negative regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
synonym: "down regulation of mast cell cytokine production" EXACT []
synonym: "down-regulation of mast cell cytokine production" EXACT []
synonym: "downregulation of mast cell cytokine production" EXACT []
synonym: "inhibition of mast cell cytokine production" NARROW []
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0032763 ! regulation of mast cell cytokine production
relationship: negatively_regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032765
name: positive regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
synonym: "activation of mast cell cytokine production" NARROW []
synonym: "stimulation of mast cell cytokine production" NARROW []
synonym: "up regulation of mast cell cytokine production" EXACT []
synonym: "up-regulation of mast cell cytokine production" EXACT []
synonym: "upregulation of mast cell cytokine production" EXACT []
is_a: GO:0032763 ! regulation of mast cell cytokine production
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
relationship: positively_regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032766
name: NHE3/E3KARP/ACTN4 complex
namespace: cellular_component
def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184]
synonym: "NHE3/E3KARP/alpha-actinin complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0032767
name: copper-dependent protein binding
namespace: molecular_function
def: "Binding to a protein or protein complex, in the presence of copper." [GOC:ecd, PMID:16884690]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032768
name: regulation of monooxygenase activity
namespace: biological_process
def: "Any process that modulates the activity of a monooxygenase." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0032769
name: negative regulation of monooxygenase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of monooxygenase activity" EXACT []
synonym: "down-regulation of monooxygenase activity" EXACT []
synonym: "downregulation of monooxygenase activity" EXACT []
synonym: "inhibition of monooxygenase activity" NARROW []
is_a: GO:0032768 ! regulation of monooxygenase activity
is_a: GO:0051354 ! negative regulation of oxidoreductase activity

[Term]
id: GO:0032770
name: positive regulation of monooxygenase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of monooxygenase activity" NARROW []
synonym: "stimulation of monooxygenase activity" NARROW []
synonym: "up regulation of monooxygenase activity" EXACT []
synonym: "up-regulation of monooxygenase activity" EXACT []
synonym: "upregulation of monooxygenase activity" EXACT []
is_a: GO:0032768 ! regulation of monooxygenase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity

[Term]
id: GO:0032771
name: regulation of tyrosinase activity
namespace: biological_process
def: "Any process that modulates the activity of a tyrosinase enzyme." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]
subset: gocheck_obsoletion_candidate
synonym: "regulation of monophenol monooxygenase activity" RELATED []
synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0032772
name: obsolete negative regulation of tyrosinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the activity of a tyrosinase enzyme." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of monophenol oxygenase activity" EXACT []
synonym: "down-regulation of monophenol oxygenase activity" EXACT []
synonym: "downregulation of monophenol oxygenase activity" EXACT []
synonym: "inhibition of monophenol oxygenase activity" NARROW []
synonym: "negative regulation of monophenol monooxygenase activity" RELATED []
synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997]
is_obsolete: true

[Term]
id: GO:0032773
name: positive regulation of tyrosinase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a tyrosinase enzyme monophenol oxygenase." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]
subset: gocheck_obsoletion_candidate
synonym: "activation of monophenol oxygenase activity" NARROW []
synonym: "positive regulation of monophenol monooxygenase activity" RELATED []
synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997]
synonym: "stimulation of monophenol oxygenase activity" NARROW []
synonym: "up regulation of monophenol oxygenase activity" EXACT []
synonym: "up-regulation of monophenol oxygenase activity" EXACT []
synonym: "upregulation of monophenol oxygenase activity" EXACT []
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0032771 ! regulation of tyrosinase activity

[Term]
id: GO:0032774
name: RNA biosynthetic process
namespace: biological_process
alt_id: GO:0062103
def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]
comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
subset: gocheck_do_not_annotate
synonym: "double-stranded RNA biosynthesis" NARROW []
synonym: "double-stranded RNA biosynthetic process" NARROW []
synonym: "dsRNA biosynthesis" NARROW []
synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl]
synonym: "RNA anabolism" EXACT []
synonym: "RNA biosynthesis" EXACT []
synonym: "RNA formation" EXACT []
synonym: "RNA synthesis" EXACT []
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0141187 ! nucleic acid biosynthetic process

[Term]
id: GO:0032775
name: obsolete DNA methylation on adenine
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "adenine methylation" RELATED []
is_obsolete: true
consider: GO:0009007
consider: GO:0009307
consider: GO:0040029

[Term]
id: GO:0032776
name: obsolete DNA methylation on cytosine
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytosine methylation" BROAD []
is_obsolete: true
consider: GO:0003886
consider: GO:0031507

[Term]
id: GO:0032777
name: piccolo histone acetyltransferase complex
namespace: cellular_component
def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [GOC:rb, PMID:12782659, PMID:15964809]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0032778
name: P-type cobalt transporter activity
namespace: molecular_function
alt_id: GO:0015632
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Co2+(out) = ADP + phosphate + Co2+(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729]
synonym: "ATP-dependent cobalt transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled cobalt transmembrane transporter activity" RELATED []
synonym: "cobalt porter activity" RELATED []
synonym: "cobalt transporting ATPase activity" RELATED []
synonym: "cobalt-transporting ATPase activity" RELATED []
xref: MetaCyc:TRANS-RXN-459
xref: RHEA:32779
is_a: GO:0015087 ! cobalt ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0032780
name: negative regulation of ATP-dependent activity
namespace: biological_process
def: "Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of ATPase activity" EXACT []
synonym: "down-regulation of ATPase activity" EXACT []
synonym: "downregulation of ATPase activity" EXACT []
synonym: "inhibition of ATPase activity" NARROW []
synonym: "negative regulation of adenosinetriphosphatase activity" EXACT []
synonym: "negative regulation of ATPase activity" EXACT []
is_a: GO:0043462 ! regulation of ATP-dependent activity
is_a: GO:0044092 ! negative regulation of molecular function

[Term]
id: GO:0032781
name: positive regulation of ATP-dependent activity
namespace: biological_process
def: "Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of ATPase activity" NARROW []
synonym: "positive regulation of adenosinetriphosphatase activity" EXACT []
synonym: "positive regulation of ATPase activity" EXACT []
synonym: "stimulation of ATPase activity" NARROW []
synonym: "up regulation of ATPase activity" EXACT []
synonym: "up-regulation of ATPase activity" EXACT []
synonym: "upregulation of ATPase activity" EXACT []
is_a: GO:0043462 ! regulation of ATP-dependent activity
is_a: GO:0044093 ! positive regulation of molecular function

[Term]
id: GO:0032782
name: bile acid secretion
namespace: biological_process
def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0032783
name: super elongation complex
namespace: cellular_component
def: "A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae." [PMID:17150956, PMID:30102332]
synonym: "ELL-EAF complex" NARROW []
synonym: "ELL-EAF-EBP complex" NARROW []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032784
name: regulation of DNA-templated transcription elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "regulation of DNA-templated transcription, elongation" EXACT []
synonym: "regulation of RNA elongation" BROAD []
synonym: "regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "regulation of transcriptional elongation" BROAD []
synonym: "transcription elongation regulator activity" RELATED []
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0006354 ! DNA-templated transcription elongation

[Term]
id: GO:0032785
name: negative regulation of DNA-templated transcription, elongation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "down regulation of RNA elongation" BROAD []
synonym: "down-regulation of RNA elongation" BROAD []
synonym: "downregulation of RNA elongation" BROAD []
synonym: "inhibition of RNA elongation" BROAD []
synonym: "negative regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "negative regulation of transcription elongation" BROAD []
synonym: "negative regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "negative regulation of transcriptional elongation" BROAD []
synonym: "negative transcription elongation regulator activity" RELATED []
is_a: GO:0032784 ! regulation of DNA-templated transcription elongation
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
relationship: negatively_regulates GO:0006354 ! DNA-templated transcription elongation

[Term]
id: GO:0032786
name: positive regulation of DNA-templated transcription, elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "activation of RNA elongation" BROAD []
synonym: "positive regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "positive regulation of transcription elongation" BROAD []
synonym: "positive regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "positive regulation of transcriptional elongation" BROAD []
synonym: "positive transcription elongation regulator activity" RELATED []
synonym: "stimulation of RNA elongation" BROAD []
synonym: "up regulation of RNA elongation" BROAD []
synonym: "up-regulation of RNA elongation" BROAD []
synonym: "upregulation of RNA elongation" BROAD []
is_a: GO:0032784 ! regulation of DNA-templated transcription elongation
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
relationship: positively_regulates GO:0006354 ! DNA-templated transcription elongation

[Term]
id: GO:0032787
name: monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]
subset: goslim_yeast
synonym: "monocarboxylate metabolic process" EXACT []
synonym: "monocarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0032788
name: saturated monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk]
synonym: "saturated monocarboxylate metabolic process" EXACT []
synonym: "saturated monocarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0032789
name: unsaturated monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk]
synonym: "unsaturated monocarboxylate metabolic process" EXACT []
synonym: "unsaturated monocarboxylic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0032790
name: ribosome disassembly
namespace: biological_process
def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk]
synonym: "ribosome dissociation factor" RELATED []
synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391]
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0032791
name: lead ion binding
namespace: molecular_function
def: "Binding to lead (Pb) ions." [GOC:mah]
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0032792
name: negative regulation of CREB transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "CREB inhibitor" RELATED []
synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity

[Term]
id: GO:0032793
name: positive regulation of CREB transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "activation of CREB" EXACT []
synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "CREB activator" RELATED []
is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity

[Term]
id: GO:0032794
name: GTPase activating protein binding
namespace: molecular_function
def: "Binding to a GTPase activating protein." [GOC:nln]
synonym: "GAP binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032795
name: heterotrimeric G-protein binding
namespace: molecular_function
def: "Binding to a heterotrimeric G-protein." [GOC:nln]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0032796
name: uropod organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]
synonym: "uropod organisation" EXACT [GOC:mah]
synonym: "uropod organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0032797
name: SMN complex
namespace: cellular_component
def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]
comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'.
synonym: "SMN core complex" EXACT []
synonym: "survival motor neuron complex" EXACT []
is_a: GO:0120114 ! Sm-like protein family complex
relationship: part_of GO:0034719 ! SMN-Sm protein complex

[Term]
id: GO:0032798
name: Swi5-Sfr1 complex
namespace: cellular_component
def: "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379]
comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p.
synonym: "Sae3-Mei5 complex" EXACT [GOC:elh, GOC:vw]
synonym: "Swi5 complex" BROAD []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0032799
name: low-density lipoprotein receptor particle metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk]
synonym: "LDL receptor metabolic process" EXACT []
synonym: "low-density lipoprotein receptor metabolic process" EXACT [GOC:bf, GOC:dph]
synonym: "low-density lipoprotein receptor metabolism" EXACT []
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0032800
name: obsolete receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
comment: The reason for obsoletion is that this represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "receptor anabolism" EXACT []
synonym: "receptor biosynthesis" EXACT []
synonym: "receptor formation" EXACT []
synonym: "receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0032801
name: receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "receptor breakdown" EXACT []
synonym: "receptor catabolism" EXACT []
synonym: "receptor degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0043112 ! receptor metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0032802
name: low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "LDL receptor breakdown" EXACT []
synonym: "LDL receptor catabolic process" EXACT []
synonym: "LDL receptor catabolism" RELATED []
synonym: "LDL receptor degradation" EXACT []
synonym: "low-density lipoprotein receptor breakdown" EXACT []
synonym: "low-density lipoprotein receptor catabolic process" EXACT [GOC:dph]
synonym: "low-density lipoprotein receptor catabolism" EXACT []
synonym: "low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process
is_a: GO:0032801 ! receptor catabolic process

[Term]
id: GO:0032803
name: regulation of low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah]
synonym: "regulation of LDLr catabolic process" EXACT []
synonym: "regulation of LDLr catabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph]
synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:2000644 ! regulation of receptor catabolic process
relationship: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process

[Term]
id: GO:0032804
name: negative regulation of low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah]
synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:dph]
synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:2000645 ! negative regulation of receptor catabolic process
relationship: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process

[Term]
id: GO:0032805
name: positive regulation of low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah]
synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph]
synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT []
synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT []
is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:2000646 ! positive regulation of receptor catabolic process
relationship: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process

[Term]
id: GO:0032806
name: carboxy-terminal domain protein kinase complex
namespace: cellular_component
def: "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683]
synonym: "CTDK complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0032807
name: DNA ligase IV complex
namespace: cellular_component
def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503]
synonym: "DNA ligase IV-XRCC4 complex" EXACT [GOC:mah]
is_a: GO:0070419 ! nonhomologous end joining complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0032808
name: lacrimal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035272 ! exocrine system development

[Term]
id: GO:0032809
name: neuronal cell body membrane
namespace: cellular_component
def: "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites." [GOC:jl]
synonym: "neuron cell body membrane" EXACT []
synonym: "neuronal cell soma membrane" EXACT []
is_a: GO:0044298 ! cell body membrane
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0032810
name: sterol response element binding
namespace: molecular_function
def: "Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399]
synonym: "SRE binding" EXACT []
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0032811
name: negative regulation of epinephrine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk]
synonym: "down regulation of epinephrine secretion" EXACT []
synonym: "down-regulation of epinephrine secretion" EXACT []
synonym: "downregulation of epinephrine secretion" EXACT []
synonym: "inhibition of epinephrine secretion" NARROW []
synonym: "negative regulation of adrenaline secretion" EXACT []
is_a: GO:0014060 ! regulation of epinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
relationship: negatively_regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0032812
name: positive regulation of epinephrine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk]
synonym: "activation of epinephrine secretion" NARROW []
synonym: "positive regulation of adrenaline secretion" EXACT []
synonym: "stimulation of epinephrine secretion" NARROW []
synonym: "up regulation of epinephrine secretion" EXACT []
synonym: "up-regulation of epinephrine secretion" EXACT []
synonym: "upregulation of epinephrine secretion" EXACT []
is_a: GO:0014060 ! regulation of epinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
relationship: positively_regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0032813
name: tumor necrosis factor receptor superfamily binding
namespace: molecular_function
def: "Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]
synonym: "TNF receptor superfamily binding" EXACT []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0032814
name: regulation of natural killer cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "regulation of NK cell activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032815
name: negative regulation of natural killer cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "down regulation of natural killer cell activation" EXACT []
synonym: "down-regulation of natural killer cell activation" EXACT []
synonym: "downregulation of natural killer cell activation" EXACT []
synonym: "inhibition of natural killer cell activation" NARROW []
synonym: "negative regulation of NK cell activation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032816
name: positive regulation of natural killer cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "activation of natural killer cell activation" NARROW []
synonym: "positive regulation of NK cell activation" EXACT []
synonym: "stimulation of natural killer cell activation" NARROW []
synonym: "up regulation of natural killer cell activation" EXACT []
synonym: "up-regulation of natural killer cell activation" EXACT []
synonym: "upregulation of natural killer cell activation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032817
name: regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "regulation of NK cell proliferation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
relationship: regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032818
name: negative regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "down regulation of natural killer cell proliferation" EXACT []
synonym: "down-regulation of natural killer cell proliferation" EXACT []
synonym: "downregulation of natural killer cell proliferation" EXACT []
synonym: "inhibition of natural killer cell proliferation" NARROW []
synonym: "negative regulation of NK cell proliferation" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032819
name: positive regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "activation of natural killer cell proliferation" NARROW []
synonym: "positive regulation of NK cell proliferation" EXACT []
synonym: "stimulation of natural killer cell proliferation" NARROW []
synonym: "up regulation of natural killer cell proliferation" EXACT []
synonym: "up-regulation of natural killer cell proliferation" EXACT []
synonym: "upregulation of natural killer cell proliferation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
relationship: positively_regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032820
name: regulation of natural killer cell proliferation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah]
synonym: "regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "regulation of NK cell proliferation during immune response" RELATED []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002324 ! natural killer cell proliferation involved in immune response

[Term]
id: GO:0032821
name: negative regulation of natural killer cell proliferation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah]
synonym: "down regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "down-regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "downregulation of natural killer cell proliferation during immune response" RELATED []
synonym: "inhibition of natural killer cell proliferation during immune response" NARROW []
synonym: "negative regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "negative regulation of NK cell proliferation during immune response" RELATED []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0032818 ! negative regulation of natural killer cell proliferation
is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response

[Term]
id: GO:0032822
name: positive regulation of natural killer cell proliferation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah]
synonym: "activation of natural killer cell proliferation during immune response" NARROW []
synonym: "positive regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "positive regulation of NK cell proliferation during immune response" RELATED []
synonym: "stimulation of natural killer cell proliferation during immune response" NARROW []
synonym: "up regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "up-regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "upregulation of natural killer cell proliferation during immune response" RELATED []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0032819 ! positive regulation of natural killer cell proliferation
is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response
relationship: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response

[Term]
id: GO:0032823
name: regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of natural killer cell development" RELATED [GOC:add]
synonym: "regulation of NK cell differentiation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0045619 ! regulation of lymphocyte differentiation
relationship: regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032824
name: negative regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of natural killer cell differentiation" EXACT []
synonym: "down-regulation of natural killer cell differentiation" EXACT []
synonym: "downregulation of natural killer cell differentiation" EXACT []
synonym: "inhibition of natural killer cell differentiation" NARROW []
synonym: "negative regulation of natural killer cell development" RELATED [GOC:add]
synonym: "negative regulation of NK cell differentiation" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032825
name: positive regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of natural killer cell differentiation" NARROW []
synonym: "positive regulation of natural killer cell development" RELATED [GOC:add]
synonym: "positive regulation of NK cell differentiation" EXACT []
synonym: "stimulation of natural killer cell differentiation" NARROW []
synonym: "up regulation of natural killer cell differentiation" EXACT []
synonym: "up-regulation of natural killer cell differentiation" EXACT []
synonym: "upregulation of natural killer cell differentiation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
relationship: positively_regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032826
name: regulation of natural killer cell differentiation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "regulation of NK cell differentiation during immune response" RELATED []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0032823 ! regulation of natural killer cell differentiation
relationship: regulates GO:0002325 ! natural killer cell differentiation involved in immune response

[Term]
id: GO:0032827
name: negative regulation of natural killer cell differentiation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "down-regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "downregulation of natural killer cell differentiation during immune response" RELATED []
synonym: "inhibition of natural killer cell differentiation during immune response" NARROW []
synonym: "negative regulation of natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "negative regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "negative regulation of NK cell differentiation during immune response" RELATED []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0032824 ! negative regulation of natural killer cell differentiation
is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response

[Term]
id: GO:0032828
name: positive regulation of natural killer cell differentiation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of natural killer cell differentiation during immune response" NARROW []
synonym: "positive regulation of natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "positive regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "positive regulation of NK cell differentiation during immune response" RELATED []
synonym: "stimulation of natural killer cell differentiation during immune response" NARROW []
synonym: "up regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "up-regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "upregulation of natural killer cell differentiation during immune response" RELATED []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0032825 ! positive regulation of natural killer cell differentiation
is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response

[Term]
id: GO:0032829
name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032830
name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation
relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032831
name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation
relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032832
name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

[Term]
id: GO:0032833
name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add]
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

[Term]
id: GO:0032834
name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add]
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

[Term]
id: GO:0032835
name: glomerulus development
namespace: biological_process
def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." [GOC:mah, GOC:mtg_kidney_jan10]
synonym: "glomerular development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0032836
name: glomerular basement membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr]
is_a: GO:0030198 ! extracellular matrix organization
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0032837
name: distributive segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart]
is_a: GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0032838
name: plasma membrane bounded cell projection cytoplasm
namespace: cellular_component
def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah]
is_a: GO:0099568 ! cytoplasmic region
relationship: part_of GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0032839
name: dendrite cytoplasm
namespace: cellular_component
def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah]
synonym: "dendritic cytoplasm" EXACT []
is_a: GO:0120111 ! neuron projection cytoplasm
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0032840
name: obsolete intramolecular proline-rich ligand binding
namespace: molecular_function
def: "OBSOLETE. Binding to a proline-rich region within the same polypeptide." [GOC:pf]
comment: Out of scope; capture mechanistic information about binding.
synonym: "intramolecular proline-rich region binding" EXACT []
is_obsolete: true

[Term]
id: GO:0032841
name: calcitonin binding
namespace: molecular_function
def: "Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd]
is_a: GO:0097644 ! calcitonin family binding

[Term]
id: GO:0032843
name: hydroperoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol." [GOC:mlg, PMID:12540833]
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0032847
name: regulation of cellular pH reduction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "regulation of cell pH reduction" EXACT []
synonym: "regulation of cellular acidification" EXACT []
synonym: "regulation of intracellular acidification" RELATED []
synonym: "regulation of intracellular pH reduction" EXACT []
synonym: "regulation of reduction of cellular pH" EXACT []
synonym: "regulation of reduction of pH in cell" EXACT []
is_a: GO:0050789 ! regulation of biological process
is_a: GO:0051453 ! regulation of intracellular pH
relationship: regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032848
name: negative regulation of cellular pH reduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "down regulation of cellular pH reduction" EXACT []
synonym: "down-regulation of cellular pH reduction" EXACT []
synonym: "downregulation of cellular pH reduction" EXACT []
synonym: "inhibition of cellular pH reduction" NARROW []
synonym: "negative regulation of cell pH reduction" EXACT []
synonym: "negative regulation of cellular acidification" EXACT []
synonym: "negative regulation of intracellular acidification" RELATED []
synonym: "negative regulation of intracellular pH reduction" EXACT []
synonym: "negative regulation of reduction of cellular pH" EXACT []
synonym: "negative regulation of reduction of pH in cell" EXACT []
is_a: GO:0032847 ! regulation of cellular pH reduction
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032849
name: positive regulation of cellular pH reduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "activation of cellular pH reduction" NARROW []
synonym: "positive regulation of cell pH reduction" EXACT []
synonym: "positive regulation of cellular acidification" EXACT []
synonym: "positive regulation of intracellular acidification" RELATED []
synonym: "positive regulation of intracellular pH reduction" EXACT []
synonym: "positive regulation of reduction of cellular pH" EXACT []
synonym: "positive regulation of reduction of pH in cell" EXACT []
synonym: "stimulation of cellular pH reduction" NARROW []
synonym: "up regulation of cellular pH reduction" EXACT []
synonym: "up-regulation of cellular pH reduction" EXACT []
synonym: "upregulation of cellular pH reduction" EXACT []
is_a: GO:0032847 ! regulation of cellular pH reduction
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032865
name: ERMES complex
namespace: cellular_component
def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles." [GOC:mcc, PMID:19556461, PMID:29279306]
synonym: "ER-mitochondria encounter structure" EXACT []
synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT []
synonym: "mitochore" EXACT [GOC:mcc]
synonym: "MMM1 complex" EXACT [GOC:mcc]
is_a: GO:0098799 ! outer mitochondrial membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0044233 ! mitochondria-associated endoplasmic reticulum membrane contact site

[Term]
id: GO:0032866
name: D-xylose reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173, RHEA:27445]
synonym: "D-xylose reductase activity" BROAD []
synonym: "D-xylose:NADP reductase activity" EXACT []
synonym: "xylose reductase activity" BROAD []
xref: MetaCyc:RXN-8773
xref: RHEA:27445
is_a: GO:0004032 ! aldose reductase (NADPH) activity

[Term]
id: GO:0032867
name: L-arabinose reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173, RHEA:25229]
synonym: "arabinose reductase activity" BROAD []
synonym: "arabinose:NADP reductase activity" BROAD []
synonym: "L-arabinose:NADP reductase activity" EXACT []
xref: KEGG_REACTION:R01759
xref: MetaCyc:RXN-8772
xref: RHEA:25229
xref: SABIO-RK:1858
is_a: GO:0004032 ! aldose reductase (NADPH) activity

[Term]
id: GO:0032868
name: response to insulin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
synonym: "response to insulin stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0032869
name: cellular response to insulin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
is_a: GO:0032868 ! response to insulin
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0032870
name: cellular response to hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]
is_a: GO:0009725 ! response to hormone
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0032871
name: regulation of karyogamy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah]
is_a: GO:1903353 ! regulation of nucleus organization
relationship: regulates GO:0000741 ! karyogamy

[Term]
id: GO:0032872
name: regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "regulation of p38 MAPK signaling" EXACT []
synonym: "regulation of p38 MAPK signalling" EXACT []
synonym: "regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade
relationship: regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032873
name: negative regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "down regulation of stress-activated MAPK cascade" EXACT []
synonym: "down-regulation of stress-activated MAPK cascade" EXACT []
synonym: "downregulation of stress-activated MAPK cascade" EXACT []
synonym: "inhibition of stress-activated MAPK cascade" NARROW []
synonym: "negative regulation of p38 MAPK signaling" EXACT []
synonym: "negative regulation of p38 MAPK signalling" EXACT []
synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade
relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032874
name: positive regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "activation of stress-activated MAPK cascade" NARROW []
synonym: "positive regulation of p38 MAPK signaling" EXACT []
synonym: "positive regulation of p38 MAPK signalling" EXACT []
synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT []
synonym: "stimulation of stress-activated MAPK cascade" NARROW []
synonym: "up regulation of stress-activated MAPK cascade" EXACT []
synonym: "up-regulation of stress-activated MAPK cascade" EXACT []
synonym: "upregulation of stress-activated MAPK cascade" EXACT []
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade
relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032875
name: regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "regulation of DNA endoreplication" EXACT []
synonym: "regulation of DNA re-duplication" EXACT []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
relationship: regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032876
name: negative regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "down regulation of DNA endoreduplication" EXACT []
synonym: "down-regulation of DNA endoreduplication" EXACT []
synonym: "downregulation of DNA endoreduplication" EXACT []
synonym: "inhibition of DNA endoreduplication" NARROW []
synonym: "negative regulation of DNA endoreplication" EXACT []
synonym: "negative regulation of DNA re-duplication" EXACT []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0032875 ! regulation of DNA endoreduplication
is_a: GO:2000104 ! negative regulation of DNA-templated DNA replication
relationship: negatively_regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032877
name: positive regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "activation of DNA endoreduplication" NARROW []
synonym: "positive regulation of DNA endoreplication" EXACT []
synonym: "positive regulation of DNA re-duplication" EXACT []
synonym: "stimulation of DNA endoreduplication" NARROW []
synonym: "up regulation of DNA endoreduplication" EXACT []
synonym: "up-regulation of DNA endoreduplication" EXACT []
synonym: "upregulation of DNA endoreduplication" EXACT []
is_a: GO:0032875 ! regulation of DNA endoreduplication
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:2000105 ! positive regulation of DNA-templated DNA replication
relationship: positively_regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032878
name: regulation of establishment or maintenance of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0032879
name: regulation of localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "regulation of localisation" EXACT [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0051179 ! localization

[Term]
id: GO:0032880
name: regulation of protein localization
namespace: biological_process
alt_id: GO:1903827
def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_chembl
synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein localization" EXACT []
synonym: "regulation of protein localisation" EXACT [GOC:mah]
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0008104 ! protein localization

[Term]
id: GO:0032881
name: regulation of polysaccharide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0032882
name: regulation of chitin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah]
synonym: "regulation of chitin metabolism" EXACT []
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0006030 ! chitin metabolic process

[Term]
id: GO:0032883
name: regulation of chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah]
synonym: "regulation of chitin anabolism" EXACT []
synonym: "regulation of chitin biosynthesis" RELATED []
synonym: "regulation of chitin formation" EXACT []
synonym: "regulation of chitin synthesis" EXACT []
is_a: GO:0032882 ! regulation of chitin metabolic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0006031 ! chitin biosynthetic process

[Term]
id: GO:0032884
name: obsolete regulation of cell wall chitin biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah]
comment: The reason for obsoletion is that this term is mixing biological process and cellular component.
synonym: "regulation of cell wall chitin anabolism" EXACT []
synonym: "regulation of cell wall chitin biosynthesis" EXACT []
synonym: "regulation of cell wall chitin formation" EXACT []
synonym: "regulation of cell wall chitin synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0032883

[Term]
id: GO:0032885
name: regulation of polysaccharide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0000271 ! polysaccharide biosynthetic process

[Term]
id: GO:0032886
name: regulation of microtubule-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007017 ! microtubule-based process

[Term]
id: GO:0032887
name: regulation of spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032886 ! regulation of microtubule-based process
relationship: regulates GO:0051231 ! spindle elongation

[Term]
id: GO:0032888
name: regulation of mitotic spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah]
is_a: GO:0032887 ! regulation of spindle elongation
relationship: part_of GO:0033047 ! regulation of mitotic sister chromatid segregation
relationship: regulates GO:0000022 ! mitotic spindle elongation

[Term]
id: GO:0032889
name: regulation of vacuole fusion, non-autophagic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah]
is_a: GO:0044088 ! regulation of vacuole organization
relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic

[Term]
id: GO:0032890
name: regulation of organic acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032891
name: negative regulation of organic acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of organic acid transport" EXACT []
synonym: "down-regulation of organic acid transport" EXACT []
synonym: "downregulation of organic acid transport" EXACT []
synonym: "inhibition of organic acid transport" NARROW []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032892
name: positive regulation of organic acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of organic acid transport" NARROW []
synonym: "stimulation of organic acid transport" NARROW []
synonym: "up regulation of organic acid transport" EXACT []
synonym: "up-regulation of organic acid transport" EXACT []
synonym: "upregulation of organic acid transport" EXACT []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032896
name: palmitoyl-CoA 9-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv, PMID:16443825]
synonym: "palmitoyl-CoA delta9-desaturase activity" EXACT []
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0032897
name: negative regulation of viral transcription
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:mah]
synonym: "down regulation of viral transcription" EXACT []
synonym: "down-regulation of viral transcription" EXACT []
synonym: "downregulation of viral transcription" EXACT []
synonym: "inhibition of viral transcription" NARROW []
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:0048525 ! negative regulation of viral process
relationship: negatively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0032898
name: neurotrophin production
namespace: biological_process
def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0032899
name: regulation of neurotrophin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032900
name: negative regulation of neurotrophin production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
synonym: "down regulation of neurotrophin production" EXACT []
synonym: "down-regulation of neurotrophin production" EXACT []
synonym: "downregulation of neurotrophin production" EXACT []
synonym: "inhibition of neurotrophin production" NARROW []
is_a: GO:0032899 ! regulation of neurotrophin production
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032901
name: positive regulation of neurotrophin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
synonym: "activation of neurotrophin production" NARROW []
synonym: "stimulation of neurotrophin production" NARROW []
synonym: "up regulation of neurotrophin production" EXACT []
synonym: "up-regulation of neurotrophin production" EXACT []
synonym: "upregulation of neurotrophin production" EXACT []
is_a: GO:0032899 ! regulation of neurotrophin production
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032902
name: nerve growth factor production
namespace: biological_process
def: "The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah]
synonym: "beta-nerve growth factor production" EXACT [PR:000011194]
synonym: "NGF production" EXACT []
is_a: GO:0032898 ! neurotrophin production

[Term]
id: GO:0032903
name: regulation of nerve growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah]
synonym: "regulation of beta-nerve growth factor production" EXACT [PR:000011194]
synonym: "regulation of NGF production" EXACT []
is_a: GO:0032899 ! regulation of neurotrophin production
relationship: regulates GO:0032902 ! nerve growth factor production

[Term]
id: GO:0032904
name: negative regulation of nerve growth factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah]
synonym: "down regulation of nerve growth factor production" EXACT []
synonym: "down-regulation of nerve growth factor production" EXACT []
synonym: "downregulation of nerve growth factor production" EXACT []
synonym: "inhibition of nerve growth factor production" NARROW []
synonym: "negative regulation of NGF production" EXACT []
is_a: GO:0032900 ! negative regulation of neurotrophin production
is_a: GO:0032903 ! regulation of nerve growth factor production
relationship: negatively_regulates GO:0032902 ! nerve growth factor production

[Term]
id: GO:0032905
name: transforming growth factor beta1 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B1 production" EXACT []
synonym: "TGFB1 production" EXACT []
synonym: "transforming growth factor-beta1 production" EXACT [GOC:bf]
is_a: GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0032906
name: transforming growth factor beta2 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B2 production" EXACT []
synonym: "TGFB2 production" EXACT []
synonym: "transforming growth factor-beta2 production" EXACT [GOC:bf]
is_a: GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0032907
name: transforming growth factor beta3 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B3 production" EXACT []
synonym: "TGFB3 production" EXACT []
synonym: "transforming growth factor-beta3 production" EXACT [GOC:bf]
is_a: GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0032908
name: regulation of transforming growth factor beta1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "regulation of TGF-B1 production" EXACT []
synonym: "regulation of TGFB1 production" EXACT []
synonym: "regulation of transforming growth factor-beta1 production" EXACT [GOC:bf]
is_a: GO:0071634 ! regulation of transforming growth factor beta production
relationship: regulates GO:0032905 ! transforming growth factor beta1 production

[Term]
id: GO:0032909
name: regulation of transforming growth factor beta2 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "regulation of TGF-B2 production" EXACT []
synonym: "regulation of TGFB2 production" EXACT []
synonym: "regulation of transforming growth factor-beta2 production" EXACT [GOC:bf]
is_a: GO:0071634 ! regulation of transforming growth factor beta production
relationship: regulates GO:0032906 ! transforming growth factor beta2 production

[Term]
id: GO:0032910
name: regulation of transforming growth factor beta3 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "regulation of TGF-B3 production" EXACT []
synonym: "regulation of TGFB3 production" EXACT []
synonym: "regulation of transforming growth factor-beta3 production" EXACT [GOC:bf]
is_a: GO:0071634 ! regulation of transforming growth factor beta production
relationship: regulates GO:0032907 ! transforming growth factor beta3 production

[Term]
id: GO:0032911
name: negative regulation of transforming growth factor beta1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta1 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta1 production" EXACT []
synonym: "downregulation of transforming growth factor-beta1 production" EXACT []
synonym: "inhibition of transforming growth factor-beta1 production" NARROW []
synonym: "negative regulation of TGF-B1 production" EXACT []
synonym: "negative regulation of TGFB1 production" EXACT []
synonym: "negative regulation of transforming growth factor-beta1 production" EXACT [GOC:bf]
is_a: GO:0032908 ! regulation of transforming growth factor beta1 production
is_a: GO:0071635 ! negative regulation of transforming growth factor beta production
relationship: negatively_regulates GO:0032905 ! transforming growth factor beta1 production

[Term]
id: GO:0032912
name: negative regulation of transforming growth factor beta2 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta2 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta2 production" EXACT []
synonym: "downregulation of transforming growth factor-beta2 production" EXACT []
synonym: "inhibition of transforming growth factor-beta2 production" NARROW []
synonym: "negative regulation of TGF-B2 production" EXACT []
synonym: "negative regulation of TGFB2 production" EXACT []
synonym: "negative regulation of transforming growth factor-beta2 production" EXACT [GOC:bf]
is_a: GO:0032909 ! regulation of transforming growth factor beta2 production
is_a: GO:0071635 ! negative regulation of transforming growth factor beta production
relationship: negatively_regulates GO:0032906 ! transforming growth factor beta2 production

[Term]
id: GO:0032913
name: negative regulation of transforming growth factor beta3 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta3 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta3 production" EXACT []
synonym: "downregulation of transforming growth factor-beta3 production" EXACT []
synonym: "inhibition of transforming growth factor-beta3 production" NARROW []
synonym: "negative regulation of TGF-B3 production" EXACT []
synonym: "negative regulation of TGFB3 production" EXACT []
synonym: "negative regulation of transforming growth factor-beta3 production" EXACT [GOC:bf]
is_a: GO:0032910 ! regulation of transforming growth factor beta3 production
is_a: GO:0071635 ! negative regulation of transforming growth factor beta production
relationship: negatively_regulates GO:0032907 ! transforming growth factor beta3 production

[Term]
id: GO:0032914
name: positive regulation of transforming growth factor beta1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "activation of transforming growth factor-beta1 production" NARROW [GOC:bf]
synonym: "positive regulation of TGF-B1 production" EXACT []
synonym: "positive regulation of TGFB1 production" EXACT []
synonym: "stimulation of transforming growth factor-beta1 production" NARROW []
synonym: "up regulation of transforming growth factor-beta1 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta1 production" EXACT []
synonym: "upregulation of transforming growth factor-beta1 production" EXACT []
is_a: GO:0032908 ! regulation of transforming growth factor beta1 production
is_a: GO:0071636 ! positive regulation of transforming growth factor beta production
relationship: positively_regulates GO:0032905 ! transforming growth factor beta1 production

[Term]
id: GO:0032915
name: positive regulation of transforming growth factor beta2 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "activation of transforming growth factor-beta2 production" NARROW []
synonym: "positive regulation of TGF-B2 production" EXACT []
synonym: "positive regulation of TGFB2 production" EXACT []
synonym: "positive regulation of transforming growth factor-beta2 production" EXACT [GOC:bf]
synonym: "stimulation of transforming growth factor-beta2 production" NARROW []
synonym: "up regulation of transforming growth factor-beta2 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta2 production" EXACT []
synonym: "upregulation of transforming growth factor-beta2 production" EXACT []
is_a: GO:0032909 ! regulation of transforming growth factor beta2 production
is_a: GO:0071636 ! positive regulation of transforming growth factor beta production
relationship: positively_regulates GO:0032906 ! transforming growth factor beta2 production

[Term]
id: GO:0032916
name: positive regulation of transforming growth factor beta3 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "activation of transforming growth factor-beta3 production" NARROW []
synonym: "positive regulation of TGF-B3 production" EXACT []
synonym: "positive regulation of TGFB3 production" EXACT []
synonym: "positive regulation of transforming growth factor-beta3 production" EXACT [GOC:bf]
synonym: "stimulation of transforming growth factor-beta3 production" NARROW []
synonym: "up regulation of transforming growth factor-beta3 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta3 production" EXACT []
synonym: "upregulation of transforming growth factor-beta3 production" EXACT []
is_a: GO:0032910 ! regulation of transforming growth factor beta3 production
is_a: GO:0071636 ! positive regulation of transforming growth factor beta production
relationship: positively_regulates GO:0032907 ! transforming growth factor beta3 production

[Term]
id: GO:0032917
name: polyamine acetylation
namespace: biological_process
def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg]
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0032918
name: spermidine acetylation
namespace: biological_process
def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0008216 ! spermidine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032919
name: spermine acetylation
namespace: biological_process
def: "The modification of spermine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0008215 ! spermine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032920
name: putrescine acetylation
namespace: biological_process
def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0009445 ! putrescine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032921
name: sarcosine oxidase complex
namespace: cellular_component
def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg]
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0032922
name: circadian regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]
synonym: "circadian regulation of protein expression" RELATED []
synonym: "diurnal variation of gene expression" RELATED []
synonym: "diurnal variation of protein expression" RELATED []
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0032923
name: organic phosphonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js]
synonym: "organophosphonate biosynthetic process" RELATED []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0019634 ! organic phosphonate metabolic process

[Term]
id: GO:0032924
name: activin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling]
synonym: "activin receptor signalling pathway" EXACT []
is_a: GO:0141091 ! transforming growth factor beta receptor superfamily signaling pathway

[Term]
id: GO:0032925
name: regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
synonym: "regulation of activin receptor signalling pathway" EXACT []
synonym: "regulation of activin signaling pathway" RELATED []
synonym: "regulation of activin signalling pathway" RELATED []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032926
name: negative regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
synonym: "down regulation of activin receptor signaling pathway" EXACT []
synonym: "down-regulation of activin receptor signaling pathway" EXACT []
synonym: "downregulation of activin receptor signaling pathway" EXACT []
synonym: "inhibition of activin receptor signaling pathway" NARROW []
synonym: "negative regulation of activin receptor signalling pathway" EXACT []
synonym: "negative regulation of activin signaling pathway" RELATED []
synonym: "negative regulation of activin signalling pathway" RELATED []
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032927
name: positive regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
synonym: "activation of activin receptor signaling pathway" NARROW []
synonym: "positive regulation of activin receptor signalling pathway" EXACT []
synonym: "positive regulation of activin signaling pathway" RELATED []
synonym: "positive regulation of activin signalling pathway" RELATED []
synonym: "stimulation of activin receptor signaling pathway" NARROW []
synonym: "up regulation of activin receptor signaling pathway" EXACT []
synonym: "up-regulation of activin receptor signaling pathway" EXACT []
synonym: "upregulation of activin receptor signaling pathway" EXACT []
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032928
name: regulation of superoxide anion generation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "regulation of superoxide release" EXACT [GOC:dph, GOC:tb]
is_a: GO:0090322 ! regulation of superoxide metabolic process
relationship: regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032929
name: negative regulation of superoxide anion generation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "down regulation of superoxide release" EXACT []
synonym: "down-regulation of superoxide release" EXACT []
synonym: "downregulation of superoxide release" EXACT []
synonym: "inhibition of superoxide release" NARROW []
synonym: "negative regulation of superoxide release" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032928 ! regulation of superoxide anion generation
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
relationship: negatively_regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032930
name: positive regulation of superoxide anion generation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "activation of superoxide release" NARROW []
synonym: "positive regulation of superoxide release" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of superoxide release" NARROW []
synonym: "up regulation of superoxide release" EXACT []
synonym: "up-regulation of superoxide release" EXACT []
synonym: "upregulation of superoxide release" EXACT []
is_a: GO:0032928 ! regulation of superoxide anion generation
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
relationship: positively_regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032931
name: histone H3K56 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [PMID:19056256]
synonym: "histone acetylase activity (H3-K56 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K56 specific)" EXACT []
synonym: "histone H3-K56 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K56 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0032932
name: negative regulation of astral microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah]
synonym: "astral microtubule stabilization" EXACT []
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0090224 ! regulation of spindle organization
relationship: negatively_regulates GO:0060172 ! astral microtubule depolymerization

[Term]
id: GO:0032933
name: SREBP signaling pathway
namespace: biological_process
alt_id: GO:0006994
alt_id: GO:0030967
alt_id: GO:0035104
def: "The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]
synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW []
synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT []
synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT []
synonym: "ER to nucleus sterol response pathway" EXACT []
synonym: "ER-nuclear sterol response pathway" EXACT []
synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of transcription via sterol regulatory element binding" NARROW [GOC:vw]
synonym: "positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway" NARROW [GOC:vw]
synonym: "SREBP signalling" EXACT [GOC:bf]
synonym: "SREBP target gene transcriptional activation" EXACT []
synonym: "SREBP-mediated signaling pathway" RELATED []
synonym: "SREBP-mediated signalling pathway" EXACT []
synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung]
synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD []
synonym: "sterol response element binding protein signaling pathway" EXACT [GOC:bf]
synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW []
synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT []
synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT []
synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT []
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0071501 ! cellular response to sterol depletion

[Term]
id: GO:0032934
name: sterol binding
namespace: molecular_function
alt_id: GO:0005498
def: "Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah]
synonym: "sterol carrier activity" RELATED [GOC:mah]
is_a: GO:0005496 ! steroid binding

[Term]
id: GO:0032935
name: sterol sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah]
synonym: "sterol sensing activity" EXACT []
synonym: "sterol-sensing domain" NARROW []
is_a: GO:0106254 ! lipid sensor activity

[Term]
id: GO:0032936
name: SREBP-SCAP complex
namespace: cellular_component
def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525]
synonym: "Sre1-Scp1 complex" EXACT []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0032937
name: SREBP-SCAP-Insig complex
namespace: cellular_component
def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane." [PMID:12923525]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0032938
name: negative regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0043556 ! regulation of translation in response to oxidative stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0032939
name: positive regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "activation of translation in response to oxidative stress" NARROW []
synonym: "stimulation of translation in response to oxidative stress" NARROW []
synonym: "up regulation of translation in response to oxidative stress" EXACT []
synonym: "up-regulation of translation in response to oxidative stress" EXACT []
synonym: "upregulation of translation in response to oxidative stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
relationship: part_of GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0032940
name: secretion by cell
namespace: biological_process
def: "The controlled release of a substance by a cell." [GOC:mah]
synonym: "cellular secretion" EXACT []
xref: Wikipedia:Secretion
is_a: GO:0046903 ! secretion
is_a: GO:0140352 ! export from cell

[Term]
id: GO:0032941
name: secretion by tissue
namespace: biological_process
def: "The controlled release of a substance by a tissue." [GOC:mah]
synonym: "expulsion of gland contents" RELATED [GOC:mah]
synonym: "tissue secretion" EXACT []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032942
name: inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + ADP + H+." [MetaCyc:RXN-7182, PMID:16107538]
synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" BROAD []
synonym: "inositol tetrakisphosphate 2-kinase activity" BROAD []
synonym: "inositol-tetrakisphosphate 2-kinase activity" BROAD []
xref: MetaCyc:RXN-7182
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0032943
name: mononuclear cell proliferation
namespace: biological_process
def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
synonym: "PBMC proliferation" NARROW []
synonym: "peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0032944
name: regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "regulation of PBMC proliferation" NARROW []
synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032945
name: negative regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "negative regulation of PBMC proliferation" NARROW []
synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032946
name: positive regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "activation of mononuclear cell proliferation" NARROW []
synonym: "positive regulation of PBMC proliferation" NARROW []
synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW []
synonym: "stimulation of mononuclear cell proliferation" NARROW []
synonym: "up regulation of mononuclear cell proliferation" EXACT []
synonym: "up-regulation of mononuclear cell proliferation" EXACT []
synonym: "upregulation of mononuclear cell proliferation" EXACT []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032948
name: regulation of alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah]
synonym: "regulation of alpha-glucan metabolism" EXACT []
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0032949
name: regulation of alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah]
synonym: "regulation of alpha-glucan anabolism" EXACT []
synonym: "regulation of alpha-glucan biosynthesis" EXACT []
synonym: "regulation of alpha-glucan formation" EXACT []
synonym: "regulation of alpha-glucan synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0032948 ! regulation of alpha-glucan metabolic process
relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process

[Term]
id: GO:0032950
name: regulation of beta-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah]
synonym: "regulation of beta-glucan metabolism" EXACT []
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0032951
name: regulation of beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah]
synonym: "regulation of beta-glucan anabolism" EXACT []
synonym: "regulation of beta-glucan biosynthesis" EXACT []
synonym: "regulation of beta-glucan formation" EXACT []
synonym: "regulation of beta-glucan synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
relationship: regulates GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0032952
name: regulation of (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans." [GOC:mah]
synonym: "regulation of (1->3)-beta-D-glucan metabolism" EXACT []
synonym: "regulation of 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "regulation of 1,3-beta-glucan metabolic process" BROAD []
synonym: "regulation of 1,3-beta-glucan metabolism" EXACT []
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
relationship: regulates GO:0006074 ! (1->3)-beta-D-glucan metabolic process

[Term]
id: GO:0032953
name: regulation of (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:mah]
synonym: "regulation of 1,3-beta-glucan anabolism" EXACT []
synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT []
synonym: "regulation of 1,3-beta-glucan biosynthetic process" BROAD []
synonym: "regulation of 1,3-beta-glucan formation" EXACT []
synonym: "regulation of 1,3-beta-glucan synthesis" EXACT []
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
is_a: GO:0032952 ! regulation of (1->3)-beta-D-glucan metabolic process
relationship: regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0032954
name: regulation of cytokinetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0032506 ! cytokinetic process

[Term]
id: GO:0032955
name: regulation of division septum assembly
namespace: biological_process
alt_id: GO:1901138
alt_id: GO:1902468
def: "Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "regulation of division septum formation" EXACT []
is_a: GO:1901891 ! regulation of cell septum assembly
relationship: regulates GO:0000917 ! division septum assembly

[Term]
id: GO:0032956
name: regulation of actin cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032970 ! regulation of actin filament-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: regulates GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0032957
name: inositol trisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [GOC:mah]
synonym: "inositol trisphosphate metabolism" EXACT []
synonym: "IP3 metabolic process" EXACT []
synonym: "IP3 metabolism" EXACT []
synonym: "myo-inositol trisphosphate metabolic process" NARROW []
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0032958
name: inositol phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]
synonym: "inositol phosphate anabolism" EXACT []
synonym: "inositol phosphate biosynthesis" EXACT []
synonym: "inositol phosphate formation" EXACT []
synonym: "inositol phosphate synthesis" EXACT []
synonym: "myo-inositol phosphate biosynthetic process" NARROW []
is_a: GO:0043647 ! inositol phosphate metabolic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0032959
name: inositol trisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [GOC:mah]
synonym: "inositol trisphosphate anabolism" EXACT []
synonym: "inositol trisphosphate biosynthesis" EXACT []
synonym: "inositol trisphosphate formation" EXACT []
synonym: "inositol trisphosphate synthesis" EXACT []
synonym: "IP3 biosynthesis" EXACT []
synonym: "IP3 biosynthetic process" EXACT []
synonym: "myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0032957 ! inositol trisphosphate metabolic process
is_a: GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0032960
name: regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "regulation of inositol trisphosphate anabolism" EXACT []
synonym: "regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "regulation of inositol trisphosphate formation" EXACT []
synonym: "regulation of inositol trisphosphate synthesis" EXACT []
synonym: "regulation of IP3 biosynthesis" EXACT []
synonym: "regulation of IP3 biosynthetic process" EXACT []
synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032961
name: negative regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "negative regulation of inositol trisphosphate anabolism" EXACT []
synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "negative regulation of inositol trisphosphate formation" EXACT []
synonym: "negative regulation of inositol trisphosphate synthesis" EXACT []
synonym: "negative regulation of IP3 biosynthesis" EXACT []
synonym: "negative regulation of IP3 biosynthetic process" EXACT []
synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0010920 ! negative regulation of inositol phosphate biosynthetic process
is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process
relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032962
name: positive regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "positive regulation of inositol trisphosphate anabolism" EXACT []
synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "positive regulation of inositol trisphosphate formation" EXACT []
synonym: "positive regulation of inositol trisphosphate synthesis" EXACT []
synonym: "positive regulation of IP3 biosynthesis" EXACT []
synonym: "positive regulation of IP3 biosynthetic process" EXACT []
synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process
is_a: GO:0060732 ! positive regulation of inositol phosphate biosynthetic process
relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032963
name: collagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0032964
name: collagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen anabolism" EXACT []
synonym: "collagen biosynthesis" EXACT []
synonym: "collagen formation" EXACT []
synonym: "collagen synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0032963 ! collagen metabolic process

[Term]
id: GO:0032965
name: regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "regulation of collagen anabolism" EXACT []
synonym: "regulation of collagen biosynthesis" EXACT []
synonym: "regulation of collagen formation" EXACT []
synonym: "regulation of collagen synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0010712 ! regulation of collagen metabolic process
relationship: regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032966
name: negative regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "negative regulation of collagen anabolism" EXACT []
synonym: "negative regulation of collagen biosynthesis" EXACT []
synonym: "negative regulation of collagen formation" EXACT []
synonym: "negative regulation of collagen synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032967
name: positive regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "positive regulation of collagen anabolism" EXACT []
synonym: "positive regulation of collagen biosynthesis" EXACT []
synonym: "positive regulation of collagen formation" EXACT []
synonym: "positive regulation of collagen synthesis" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
relationship: positively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032968
name: positive regulation of transcription elongation by RNA polymerase II
namespace: biological_process
alt_id: GO:0090040
def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "positive regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED []
synonym: "positive regulation of RNA elongation from RNA polymerase II promoter" EXACT []
synonym: "positive regulation of transcription elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation
is_a: GO:0034243 ! regulation of transcription elongation by RNA polymerase II
is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II
relationship: positively_regulates GO:0006368 ! transcription elongation by RNA polymerase II

[Term]
id: GO:0032969
name: endosomal scaffold complex
namespace: cellular_component
def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling." [PMID:15263099, PMID:16227978, PMID:17496910]
synonym: "endosomal adaptor complex" EXACT [GOC:hjd]
synonym: "MP1-p14 scaffolding complex" EXACT [GOC:mah]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031902 ! late endosome membrane

[Term]
id: GO:0032970
name: regulation of actin filament-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0030029 ! actin filament-based process

[Term]
id: GO:0032971
name: regulation of muscle filament sliding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd]
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:1903115 ! regulation of actin filament-based movement
relationship: regulates GO:0030049 ! muscle filament sliding

[Term]
id: GO:0032972
name: regulation of muscle filament sliding speed
namespace: biological_process
def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb]
is_a: GO:0032971 ! regulation of muscle filament sliding
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0032973
name: amino acid export across plasma membrane
namespace: biological_process
alt_id: GO:0044746
def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl]
synonym: "amino acid efflux" EXACT []
synonym: "amino acid export" BROAD []
synonym: "amino acid transmembrane export" BROAD []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0032974
name: amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
synonym: "amino acid efflux from vacuole" EXACT []
synonym: "vacuolar amino acid export" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0034486 ! vacuolar transmembrane transport

[Term]
id: GO:0032975
name: amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
synonym: "vacuolar amino acid import" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0034486 ! vacuolar transmembrane transport

[Term]
id: GO:0032976
name: release of matrix enzymes from mitochondria
namespace: biological_process
def: "The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process." [GOC:mah, GOC:mtg_apoptosis, PMID:9843949]
comment: Annotation to this term should be done with caution, particularly if the mechanism is not well clarified.
synonym: "mAST release from mitochondria" NARROW []
synonym: "release of aspartate aminotransferase from mitochondria" NARROW []
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0032977
name: membrane insertase activity
namespace: molecular_function
def: "Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]
xref: Reactome:R-HSA-1268025 "SAM50 complex inserts proteins into mitochondrial outer membrane"
xref: Reactome:R-HSA-1299482 "TIMM23 SORT inserts proteins into inner membrane"
xref: Reactome:R-HSA-1307803 "TIMM22 inserts proteins into inner membrane"
xref: Reactome:R-HSA-9902096 "COX18 inserts nascent MT-CO2 in COX20:TMEM77"
xref: Reactome:R-HSA-9906955 "MT-ND4 is translated"
is_a: GO:0140597 ! protein carrier chaperone

[Term]
id: GO:0032978
name: protein insertion into membrane from inner side
namespace: biological_process
def: "The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843]
synonym: "insertion of proteins into membrane from the inner side" EXACT []
is_a: GO:0051205 ! protein insertion into membrane

[Term]
id: GO:0032979
name: protein insertion into mitochondrial inner membrane from matrix
namespace: biological_process
def: "The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [GOC:vw, PMID:12880202, PMID:15473843]
synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT []
synonym: "protein insertion into mitochondrial inner membrane from matrix side" EXACT []
synonym: "protein insertion into mitochondrial membrane from inner side" EXACT []
is_a: GO:0007007 ! inner mitochondrial membrane organization
is_a: GO:0032978 ! protein insertion into membrane from inner side
is_a: GO:0051204 ! protein insertion into mitochondrial membrane

[Term]
id: GO:0032980
name: keratinocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0032981
name: mitochondrial respiratory chain complex I assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]
synonym: "mitochondrial complex I assembly" EXACT []
synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT []
is_a: GO:0010257 ! NADH dehydrogenase complex assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly

[Term]
id: GO:0032982
name: myosin filament
namespace: cellular_component
def: "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah]
synonym: "myosin thick filament" RELATED []
synonym: "thick filament" RELATED []
is_a: GO:0099512 ! supramolecular fiber

[Term]
id: GO:0032983
name: kainate selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits." [GOC:bf, PMID:18655795]
is_a: GO:0008328 ! ionotropic glutamate receptor complex
is_a: GO:0034705 ! potassium channel complex
is_a: GO:0034706 ! sodium channel complex

[Term]
id: GO:0032984
name: protein-containing complex disassembly
namespace: biological_process
alt_id: GO:0034623
alt_id: GO:0043241
alt_id: GO:0043624
def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah]
synonym: "cellular macromolecule complex disassembly" RELATED []
synonym: "cellular protein complex disassembly" RELATED []
synonym: "macromolecule complex disassembly" RELATED []
synonym: "protein complex disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0032985
name: protein-carbohydrate complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah]
is_a: GO:0032984 ! protein-containing complex disassembly
is_a: GO:0071823 ! protein-carbohydrate complex subunit organization

[Term]
id: GO:0032986
name: protein-DNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah]
synonym: "DNA-protein complex disassembly" EXACT [GOC:mah]
is_a: GO:0032984 ! protein-containing complex disassembly
is_a: GO:0071824 ! protein-DNA complex organization

[Term]
id: GO:0032987
name: protein-lipid complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah]
is_a: GO:0032984 ! protein-containing complex disassembly
is_a: GO:0071825 ! protein-lipid complex organization

[Term]
id: GO:0032988
name: protein-RNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah]
synonym: "ribonucleoprotein complex disassembly" EXACT []
synonym: "RNA-protein complex disassembly" EXACT []
synonym: "RNP complex disassembly" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly
is_a: GO:0071826 ! protein-RNA complex organization

[Term]
id: GO:0032989
name: cellular anatomical entity morphogenesis
namespace: biological_process
def: "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
synonym: "cellular component morphogenesis" EXACT []
synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0032990
name: obsolete cell part morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of a cell part are generated and organized." [GOC:mah]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0032989

[Term]
id: GO:0032991
name: protein-containing complex
namespace: cellular_component
alt_id: GO:0043234
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "macromolecular complex" EXACT []
synonym: "macromolecule complex" EXACT []
synonym: "protein complex" NARROW []
synonym: "protein containing complex" EXACT []
synonym: "protein-protein complex" NARROW []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0032992
name: protein-carbohydrate complex
namespace: cellular_component
def: "A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other." [GOC:mah]
comment: Macromolecular complexes in which the carbohydrate component is all covalently bound to protein are not considered protein carbohydrate complexes.
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0032993
name: protein-DNA complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah]
comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here.
subset: goslim_pir
synonym: "DNA-protein complex" EXACT [GOC:mah]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0032994
name: protein-lipid complex
namespace: cellular_component
def: "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah]
comment: Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes.
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0032995
name: regulation of fungal-type cell wall biogenesis
namespace: biological_process
def: "Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" RELATED [GOC:mah]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0032996
name: Bcl3-Bcl10 complex
namespace: cellular_component
def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0032997
name: Fc receptor complex
namespace: cellular_component
def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149]
subset: goslim_pir
synonym: "Fc-receptor complex" EXACT []
synonym: "FcR complex" EXACT []
synonym: "immunoglobulin receptor complex" BROAD []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0032998
name: Fc-epsilon receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149]
synonym: "FceRI complex" EXACT []
synonym: "IgE receptor complex" BROAD []
synonym: "immunoglobulin E receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0032999
name: Fc-alpha receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149, PMID:12524384]
synonym: "FcaRI complex" EXACT []
synonym: "IgA receptor complex" BROAD []
synonym: "immunoglobulin A receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033000
name: Fc-gamma receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532]
synonym: "FcgRI complex" EXACT []
synonym: "IgG receptor complex" BROAD []
synonym: "immunoglobulin G receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033001
name: Fc-gamma receptor III complex
namespace: cellular_component
def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532]
synonym: "FcgRIII complex" EXACT []
synonym: "IgG receptor complex" BROAD []
synonym: "immunoglobulin G receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033002
name: muscle cell proliferation
namespace: biological_process
def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah]
synonym: "myocyte proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0033003
name: regulation of mast cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033004
name: negative regulation of mast cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0033003 ! regulation of mast cell activation
relationship: negatively_regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033005
name: positive regulation of mast cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0033003 ! regulation of mast cell activation
relationship: positively_regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033006
name: regulation of mast cell activation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah]
synonym: "regulation of mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0033003 ! regulation of mast cell activation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002279 ! mast cell activation involved in immune response

[Term]
id: GO:0033007
name: negative regulation of mast cell activation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah]
synonym: "negative regulation of mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0033004 ! negative regulation of mast cell activation
is_a: GO:0033006 ! regulation of mast cell activation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002279 ! mast cell activation involved in immune response

[Term]
id: GO:0033008
name: positive regulation of mast cell activation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah]
synonym: "positive regulation of mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0033005 ! positive regulation of mast cell activation
is_a: GO:0033006 ! regulation of mast cell activation involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002279 ! mast cell activation involved in immune response

[Term]
id: GO:0033009
name: nucleomorph
namespace: cellular_component
def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254]
xref: Wikipedia:Nucleomorph
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0033010
name: paranodal junction
namespace: cellular_component
def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217]
synonym: "axoglial septate junction" EXACT [MP:0010735]
synonym: "paranodal axoglial junction" EXACT [PMID:18803321]
synonym: "paranodal septate junction" EXACT [MP:0010735]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0033011
name: perinuclear theca
namespace: cellular_component
def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156]
is_a: GO:0005856 ! cytoskeleton
relationship: part_of GO:0048471 ! perinuclear region of cytoplasm

[Term]
id: GO:0033012
name: porosome
namespace: cellular_component
def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225]
xref: Wikipedia:Porosome
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0033013
name: tetrapyrrole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "tetrapyrrole metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0033014
name: tetrapyrrole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]
synonym: "tetrapyrrole anabolism" EXACT []
synonym: "tetrapyrrole biosynthesis" EXACT []
synonym: "tetrapyrrole formation" EXACT []
synonym: "tetrapyrrole synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:0033015
name: tetrapyrrole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]
synonym: "tetrapyrrole breakdown" EXACT []
synonym: "tetrapyrrole catabolism" EXACT []
synonym: "tetrapyrrole degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:0033016
name: rhoptry membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a rhoptry." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0020008 ! rhoptry

[Term]
id: GO:0033017
name: sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph]
is_a: GO:0005789 ! endoplasmic reticulum membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0033018
name: sarcoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph]
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0033019
name: 5-hydroxyvalerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033020
name: cyclopentanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764]
synonym: "cyclopentanol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0033021
name: cyclopentanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764]
synonym: "cyclopentanol anabolism" EXACT []
synonym: "cyclopentanol biosynthesis" EXACT []
synonym: "cyclopentanol formation" EXACT []
synonym: "cyclopentanol synthesis" EXACT []
is_a: GO:0033020 ! cyclopentanol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0033022
name: cyclopentanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764]
synonym: "cyclopentanol breakdown" EXACT []
synonym: "cyclopentanol catabolism" EXACT []
synonym: "cyclopentanol degradation" EXACT []
is_a: GO:0033020 ! cyclopentanol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0033023
name: mast cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031]
comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0033024
name: mast cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130]
synonym: "apoptosis of mast cells" EXACT []
synonym: "mast cell apoptosis" NARROW []
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process
relationship: part_of GO:0033023 ! mast cell homeostasis

[Term]
id: GO:0033025
name: regulation of mast cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of mast cell apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
relationship: regulates GO:0033024 ! mast cell apoptotic process

[Term]
id: GO:0033026
name: negative regulation of mast cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of mast cell apoptosis" EXACT []
synonym: "down-regulation of mast cell apoptosis" EXACT []
synonym: "downregulation of mast cell apoptosis" EXACT []
synonym: "inhibition of mast cell apoptosis" NARROW []
synonym: "negative regulation of mast cell apoptosis" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0033025 ! regulation of mast cell apoptotic process
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
relationship: negatively_regulates GO:0033024 ! mast cell apoptotic process

[Term]
id: GO:0033027
name: positive regulation of mast cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of mast cell apoptosis" NARROW []
synonym: "positive regulation of mast cell apoptosis" NARROW []
synonym: "stimulation of mast cell apoptosis" NARROW []
synonym: "up regulation of mast cell apoptosis" EXACT []
synonym: "up-regulation of mast cell apoptosis" EXACT []
synonym: "upregulation of mast cell apoptosis" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0033025 ! regulation of mast cell apoptotic process
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
relationship: positively_regulates GO:0033024 ! mast cell apoptotic process

[Term]
id: GO:0033028
name: myeloid cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093]
synonym: "apoptosis of myeloid cells" EXACT []
synonym: "myeloid cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0033029
name: regulation of neutrophil apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of neutrophil apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
relationship: regulates GO:0001781 ! neutrophil apoptotic process

[Term]
id: GO:0033030
name: negative regulation of neutrophil apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of neutrophil apoptosis" EXACT []
synonym: "down-regulation of neutrophil apoptosis" EXACT []
synonym: "downregulation of neutrophil apoptosis" EXACT []
synonym: "inhibition of neutrophil apoptosis" NARROW []
synonym: "negative regulation of neutrophil apoptosis" NARROW []
is_a: GO:0033029 ! regulation of neutrophil apoptotic process
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
relationship: negatively_regulates GO:0001781 ! neutrophil apoptotic process

[Term]
id: GO:0033031
name: positive regulation of neutrophil apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of neutrophil apoptosis" NARROW []
synonym: "positive regulation of neutrophil apoptosis" NARROW []
synonym: "stimulation of neutrophil apoptosis" NARROW []
synonym: "up regulation of neutrophil apoptosis" EXACT []
synonym: "up-regulation of neutrophil apoptosis" EXACT []
synonym: "upregulation of neutrophil apoptosis" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0033029 ! regulation of neutrophil apoptotic process
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
relationship: positively_regulates GO:0001781 ! neutrophil apoptotic process

[Term]
id: GO:0033032
name: regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033033
name: negative regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of myeloid cell apoptosis" EXACT []
synonym: "down-regulation of myeloid cell apoptosis" EXACT []
synonym: "downregulation of myeloid cell apoptosis" EXACT []
synonym: "inhibition of myeloid cell apoptosis" NARROW []
synonym: "negative regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
relationship: negatively_regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033034
name: positive regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of myeloid cell apoptosis" NARROW []
synonym: "positive regulation of myeloid cell apoptosis" NARROW []
synonym: "stimulation of myeloid cell apoptosis" NARROW []
synonym: "up regulation of myeloid cell apoptosis" EXACT []
synonym: "up-regulation of myeloid cell apoptosis" EXACT []
synonym: "upregulation of myeloid cell apoptosis" EXACT []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
relationship: positively_regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033036
name: macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]
subset: goslim_flybase_ribbon
synonym: "macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0033037
name: polysaccharide localization
namespace: biological_process
def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "polysaccharide localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0033038
name: bitter taste receptor activity
namespace: molecular_function
def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033039
name: ionotropic salty taste receptor activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a soluble salty compound has been bound by the channel complex or one of its constituent parts." [GOC:mah, PMID:36332657]
is_a: GO:0170021 ! ionotropic taste receptor activity

[Term]
id: GO:0033040
name: sour taste receptor activity
namespace: molecular_function
def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033041
name: sweet taste receptor activity
namespace: molecular_function
def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033042
name: umami taste receptor activity
namespace: molecular_function
def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah]
is_a: GO:0090681 ! GPCR taste receptor activity

[Term]
id: GO:0033043
name: regulation of organelle organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]
subset: goslim_yeast
synonym: "regulation of organelle organisation" EXACT [GOC:mah]
synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0006996 ! organelle organization

[Term]
id: GO:0033044
name: regulation of chromosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]
synonym: "regulation of chromosome organisation" EXACT [GOC:mah]
synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0051276 ! chromosome organization

[Term]
id: GO:0033045
name: regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051983 ! regulation of chromosome segregation
relationship: regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033046
name: negative regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033047
name: regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033045 ! regulation of sister chromatid segregation
relationship: regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033048
name: negative regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033046 ! negative regulation of sister chromatid segregation
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033049
name: clavulanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah]
synonym: "clavulanic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:0033050
name: clavulanic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah]
synonym: "clavulanic acid anabolism" EXACT []
synonym: "clavulanic acid biosynthesis" EXACT []
synonym: "clavulanic acid formation" EXACT []
synonym: "clavulanic acid synthesis" EXACT []
xref: Wikipedia:Clavulanic_acid
is_a: GO:0033049 ! clavulanic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072339 ! lactam biosynthetic process

[Term]
id: GO:0033051
name: aminophosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah]
synonym: "aminophosphonate metabolism" EXACT []
xref: KEGG_PATHWAY:map00440
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0033052
name: cyanoamino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729]
synonym: "cyanoamino acid metabolism" EXACT []
is_a: GO:0050898 ! nitrile metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0033053
name: D-glutamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid." [GOC:jsg, GOC:mah]
synonym: "D-glutamine metabolism" EXACT []
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033054
name: D-glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [GOC:jsg, GOC:mah]
synonym: "D-glutamate metabolism" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033055
name: D-arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid." [GOC:jsg, GOC:mah]
synonym: "D-arginine metabolism" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033056
name: D-ornithine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [GOC:jsg, GOC:mah]
synonym: "D-ornithine metabolism" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033058
name: directional locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07]
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0033059
name: cellular pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]
is_a: GO:0009987 ! cellular process
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0033060
name: ocellus pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07]
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0033061
name: DNA recombinase mediator complex
namespace: cellular_component
def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992, PMID:32414915]
comment: Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0033063
name: Rad51B-Rad51C-Rad51D-XRCC2 complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "BCDX2 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0033064
name: XRCC2-RAD51D complex
namespace: cellular_component
def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548]
synonym: "DX2 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0033065
name: Rad51C-XRCC3 complex
namespace: cellular_component
alt_id: GO:0033062
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, GOC:vw, PMID:12427746, PMID:16093548, PMID:17114795]
synonym: "CX3 complex" EXACT []
synonym: "Rad55-Rad57 complex" EXACT []
synonym: "Rhp55-Rhp57 complex" RELATED []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0033066
name: Rad51B-Rad51C complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "BC complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0033067
name: macrolide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179]
synonym: "macrolide metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:0033068
name: macrolide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179]
synonym: "macrolide anabolism" EXACT []
synonym: "macrolide biosynthesis" EXACT []
synonym: "macrolide formation" EXACT []
synonym: "macrolide synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0033067 ! macrolide metabolic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0033069
name: ansamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, https://doi.org/10.1016/j.crci.2008.07.003]
synonym: "ansamycin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:0033070
name: ansamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, https://doi.org/10.1016/j.crci.2008.07.003]
synonym: "ansamycin anabolism" EXACT []
synonym: "ansamycin biosynthesis" EXACT []
synonym: "ansamycin formation" EXACT []
synonym: "ansamycin synthesis" EXACT []
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0033069 ! ansamycin metabolic process
is_a: GO:0072339 ! lactam biosynthetic process

[Term]
id: GO:0033071
name: vancomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [GOC:mah]
synonym: "vancomycin metabolism" EXACT []
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0033072
name: vancomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [GOC:mah]
synonym: "vancomycin anabolism" EXACT []
synonym: "vancomycin biosynthesis" EXACT []
synonym: "vancomycin formation" EXACT []
synonym: "vancomycin synthesis" EXACT []
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0030651 ! peptide antibiotic biosynthetic process
is_a: GO:0033071 ! vancomycin metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0033073
name: pinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, PMID:12623076]
synonym: "pinene metabolism" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process

[Term]
id: GO:0033074
name: pinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, PMID:11452597]
synonym: "pinene breakdown" EXACT []
synonym: "pinene catabolism" EXACT []
synonym: "pinene degradation" EXACT []
is_a: GO:0033073 ! pinene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process

[Term]
id: GO:0033075
name: isoquinoline alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, PMID:26503307]
synonym: "ipecac alkaloid biosynthesis" RELATED []
synonym: "isoquinoline alkaloid anabolism" EXACT []
synonym: "isoquinoline alkaloid biosynthesis" EXACT []
synonym: "isoquinoline alkaloid formation" EXACT []
synonym: "isoquinoline alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0033076
name: isoquinoline alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, PMID:26503307]
synonym: "ipecac alkaloid metabolism" RELATED []
synonym: "isoquinoline alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process

[Term]
id: GO:0033077
name: T cell differentiation in thymus
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development in thymus" RELATED [GOC:add]
synonym: "thymic T cell differentiation" EXACT []
synonym: "thymocyte cell differentiation" EXACT []
synonym: "thymocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0033078
name: extrathymic T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0033079
name: immature T cell proliferation
namespace: biological_process
def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149]
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0033080
name: immature T cell proliferation in thymus
namespace: biological_process
def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149]
synonym: "thymic T cell proliferation" EXACT []
synonym: "thymocyte cell proliferation" EXACT []
synonym: "thymocyte proliferation" EXACT []
is_a: GO:0033079 ! immature T cell proliferation
relationship: part_of GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033081
name: regulation of T cell differentiation in thymus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T cell development in thymus" RELATED [GOC:add]
synonym: "regulation of thymic T cell differentiation" EXACT []
synonym: "regulation of thymocyte cell differentiation" EXACT []
synonym: "regulation of thymocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033082
name: regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033083
name: regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0042129 ! regulation of T cell proliferation
relationship: regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033084
name: regulation of immature T cell proliferation in thymus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of thymic T cell proliferation" EXACT []
synonym: "regulation of thymocyte cell proliferation" EXACT []
synonym: "regulation of thymocyte proliferation" EXACT []
is_a: GO:0033083 ! regulation of immature T cell proliferation
relationship: regulates GO:0033080 ! immature T cell proliferation in thymus

[Term]
id: GO:0033085
name: negative regulation of T cell differentiation in thymus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "negative regulation of T cell development in thymus" RELATED [GOC:add]
synonym: "negative regulation of thymic T cell differentiation" EXACT []
synonym: "negative regulation of thymocyte cell differentiation" EXACT []
synonym: "negative regulation of thymocyte differentiation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in thymus
is_a: GO:0045581 ! negative regulation of T cell differentiation
relationship: negatively_regulates GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033086
name: negative regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "negative regulation of extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0033082 ! regulation of extrathymic T cell differentiation
is_a: GO:0045581 ! negative regulation of T cell differentiation
relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033087
name: negative regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0033083 ! regulation of immature T cell proliferation
is_a: GO:0042130 ! negative regulation of T cell proliferation
relationship: negatively_regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033088
name: negative regulation of immature T cell proliferation in thymus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
synonym: "negative regulation of thymic T cell proliferation" EXACT []
synonym: "negative regulation of thymocyte cell proliferation" EXACT []
synonym: "negative regulation of thymocyte proliferation" EXACT []
is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus
is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus
is_a: GO:0033087 ! negative regulation of immature T cell proliferation
relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus

[Term]
id: GO:0033089
name: positive regulation of T cell differentiation in thymus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "positive regulation of T cell development in thymus" RELATED [GOC:add]
synonym: "positive regulation of thymic T cell differentiation" EXACT []
synonym: "positive regulation of thymocyte cell differentiation" EXACT []
synonym: "positive regulation of thymocyte differentiation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in thymus
is_a: GO:0045582 ! positive regulation of T cell differentiation
relationship: positively_regulates GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033090
name: positive regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "positive regulation of extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0033082 ! regulation of extrathymic T cell differentiation
is_a: GO:0045582 ! positive regulation of T cell differentiation
relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033091
name: positive regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0033083 ! regulation of immature T cell proliferation
is_a: GO:0042102 ! positive regulation of T cell proliferation
relationship: positively_regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033092
name: positive regulation of immature T cell proliferation in thymus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
synonym: "positive regulation of thymic T cell proliferation" EXACT []
synonym: "positive regulation of thymocyte cell proliferation" EXACT []
synonym: "positive regulation of thymocyte proliferation" EXACT []
is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus
is_a: GO:0033091 ! positive regulation of immature T cell proliferation
relationship: positively_regulates GO:0033080 ! immature T cell proliferation in thymus

[Term]
id: GO:0033093
name: Weibel-Palade body
namespace: cellular_component
def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708]
xref: Wikipedia:Weibel-Palade_body
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0033094
name: putrescine--2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline." [EC:2.6.1.82, GOC:mlg, RHEA:12268]
synonym: "butane-1,4-diamine:2-oxoglutarate aminotransferase activity" RELATED []
synonym: "PAT activity" RELATED []
synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82]
synonym: "putrescine transaminase activity" BROAD []
synonym: "putrescine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.82]
synonym: "putrescine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.82]
synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.82]
synonym: "YgjG" RELATED [EC:2.6.1.82]
xref: EC:2.6.1.82
xref: MetaCyc:PUTTRANSAM-RXN
xref: RHEA:12268
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033095
name: aleurone grain
namespace: cellular_component
def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [PMID:22452734, Wikipedia:Aleurone]
synonym: "aleurone body" EXACT []
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0033096
name: amyloplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0033097
name: amyloplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0033096 ! amyloplast envelope

[Term]
id: GO:0033098
name: amyloplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0033097 ! amyloplast membrane

[Term]
id: GO:0033099
name: attachment organelle
namespace: cellular_component
def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [PMID:11325545, PMID:12003948]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0033100
name: NuA3 histone acetyltransferase complex
namespace: cellular_component
def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260]
is_a: GO:0070775 ! H3 histone acetyltransferase complex

[Term]
id: GO:0033101
name: cellular bud membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah]
synonym: "cellular bud plasma membrane" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0033102
name: acidocalcisome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195]
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0020022 ! acidocalcisome

[Term]
id: GO:0033103
name: protein secretion by the type VI secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'.
synonym: "protein secretion by the T6SS" EXACT []
synonym: "protein secretion by the type VI protein secretion system" EXACT []
synonym: "type VI protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0033104
name: type VI protein secretion system complex
namespace: cellular_component
def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151]
synonym: "T6SS complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0033105
name: chlorosome envelope
namespace: cellular_component
def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128]
comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'.
synonym: "chlorosome membrane" EXACT []
is_a: GO:0034646 ! organelle-enclosing lipid monolayer
relationship: part_of GO:0046858 ! chlorosome

[Term]
id: GO:0033106
name: cis-Golgi network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah]
synonym: "cis Golgi network membrane" EXACT []
synonym: "Golgi cis face membrane" RELATED []
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005801 ! cis-Golgi network

[Term]
id: GO:0033107
name: Cvt vesicle
namespace: cellular_component
def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258]
synonym: "cytoplasm to vacuole targeting vesicle" EXACT []
synonym: "cytoplasm-to-vacuole targeting vesicle" EXACT []
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0033108
name: mitochondrial respiratory chain complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex or between respiratory chain complexes to form high-order structures." [GOC:mah]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0007005 ! mitochondrion organization

[Term]
id: GO:0033110
name: Cvt vesicle membrane
namespace: cellular_component
def: "Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway." [GOC:ecd, PMID:20065092]
synonym: "cytoplasm to vacuole targeting vesicle membrane" EXACT []
synonym: "cytoplasm-to-vacuole targeting vesicle membrane" EXACT []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0033107 ! Cvt vesicle

[Term]
id: GO:0033111
name: attachment organelle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane." [GOC:ecd]
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0033099 ! attachment organelle

[Term]
id: GO:0033112
name: cyanelle envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0033113
name: cyanelle membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0033112 ! cyanelle envelope

[Term]
id: GO:0033114
name: cyanelle thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah]
is_a: GO:0031978 ! plastid thylakoid lumen
relationship: part_of GO:0009843 ! cyanelle thylakoid

[Term]
id: GO:0033115
name: cyanelle thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah]
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0009843 ! cyanelle thylakoid

[Term]
id: GO:0033116
name: endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730]
synonym: "ER-Golgi intermediate compartment membrane" EXACT []
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment

[Term]
id: GO:0033117
name: esterosome
namespace: cellular_component
def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0033118
name: esterosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0033117 ! esterosome

[Term]
id: GO:0033119
name: negative regulation of RNA splicing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0043484 ! regulation of RNA splicing
relationship: negatively_regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0033120
name: positive regulation of RNA splicing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0043484 ! regulation of RNA splicing
relationship: positively_regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0033121
name: regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "regulation of purine nucleotide breakdown" EXACT []
synonym: "regulation of purine nucleotide catabolism" EXACT []
synonym: "regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
relationship: regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033122
name: negative regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "negative regulation of purine nucleotide breakdown" EXACT []
synonym: "negative regulation of purine nucleotide catabolism" EXACT []
synonym: "negative regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033123
name: positive regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "positive regulation of purine nucleotide breakdown" EXACT []
synonym: "positive regulation of purine nucleotide catabolism" EXACT []
synonym: "positive regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030813 ! positive regulation of nucleotide catabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033124
name: obsolete regulation of GTP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "regulation of GTP breakdown" EXACT []
synonym: "regulation of GTP catabolism" EXACT []
synonym: "regulation of GTP degradation" EXACT []
is_obsolete: true
consider: GO:0043087

[Term]
id: GO:0033125
name: obsolete negative regulation of GTP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "negative regulation of GTP breakdown" EXACT []
synonym: "negative regulation of GTP catabolism" EXACT []
synonym: "negative regulation of GTP degradation" EXACT []
is_obsolete: true
consider: GO:0034260

[Term]
id: GO:0033126
name: obsolete positive regulation of GTP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "positive regulation of GTP breakdown" EXACT []
synonym: "positive regulation of GTP catabolism" EXACT []
synonym: "positive regulation of GTP degradation" EXACT []
is_obsolete: true
consider: GO:0043547

[Term]
id: GO:0033127
name: obsolete regulation of histone phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0019887

[Term]
id: GO:0033128
name: obsolete negative regulation of histone phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0004860

[Term]
id: GO:0033129
name: obsolete positive regulation of histone phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0030295

[Term]
id: GO:0033130
name: acetylcholine receptor binding
namespace: molecular_function
def: "Binding to an acetylcholine receptor." [GOC:mah]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0033131
name: regulation of glucokinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "glucokinase regulator" NARROW []
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:1903299 ! regulation of hexokinase activity

[Term]
id: GO:0033132
name: negative regulation of glucokinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of glucokinase activity" EXACT []
synonym: "down-regulation of glucokinase activity" EXACT []
synonym: "downregulation of glucokinase activity" EXACT []
synonym: "glucokinase inhibitor" NARROW []
synonym: "inhibition of glucokinase activity" NARROW []
is_a: GO:0033131 ! regulation of glucokinase activity
is_a: GO:1903300 ! negative regulation of hexokinase activity

[Term]
id: GO:0033133
name: positive regulation of glucokinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "glucokinase activator" NARROW []
synonym: "stimulation of glucokinase activity" NARROW []
synonym: "up regulation of glucokinase activity" EXACT []
synonym: "up-regulation of glucokinase activity" EXACT []
synonym: "upregulation of glucokinase activity" EXACT []
is_a: GO:0033131 ! regulation of glucokinase activity
is_a: GO:1903301 ! positive regulation of hexokinase activity

[Term]
id: GO:0033134
name: ubiquitin activating enzyme binding
namespace: molecular_function
def: "Binding to a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah]
is_a: GO:0044388 ! small protein activating enzyme binding

[Term]
id: GO:0033135
name: regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0001932 ! regulation of protein phosphorylation
relationship: regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033137
name: negative regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
relationship: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033138
name: positive regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
relationship: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033139
name: regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:1903261
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of serine phosphorylation of STAT3 protein" NARROW []
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
relationship: regulates GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033140
name: negative regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:1903262
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "down-regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "downregulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "inhibition of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "negative regulation of serine phosphorylation of STAT3 protein" NARROW []
is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation
is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033141
name: positive regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:1903263
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "positive regulation of serine phosphorylation of STAT3 protein" NARROW []
synonym: "up regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "up-regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "upregulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
is_a: GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein
relationship: positively_regulates GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033142
name: nuclear progesterone receptor binding
namespace: molecular_function
def: "Binding to a nuclear progesterone receptor." [GOC:mah]
synonym: "progesterone receptor binding" BROAD []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0033143
name: regulation of intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "regulation of steroid hormone receptor signalling pathway" BROAD []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0033144
name: negative regulation of intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "negative regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "negative regulation of steroid hormone receptor signalling pathway" BROAD [GOC:bf]
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0033145
name: positive regulation of intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "positive regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "positive regulation of steroid hormone receptor signalling pathway" BROAD []
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0033146
name: regulation of intracellular estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah]
synonym: "regulation of estrogen receptor signaling pathway" BROAD [GOC:bf]
synonym: "regulation of estrogen receptor signalling pathway" EXACT []
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
relationship: regulates GO:0030520 ! estrogen receptor signaling pathway

[Term]
id: GO:0033147
name: negative regulation of intracellular estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah]
synonym: "negative regulation of estrogen receptor signaling pathway" BROAD [GOC:bf]
synonym: "negative regulation of estrogen receptor signalling pathway" EXACT []
is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway
relationship: negatively_regulates GO:0030520 ! estrogen receptor signaling pathway

[Term]
id: GO:0033148
name: positive regulation of intracellular estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah]
synonym: "positive regulation of estrogen receptor signaling pathway" BROAD [GOC:bf]
synonym: "positive regulation of estrogen receptor signalling pathway" BROAD []
is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway
relationship: positively_regulates GO:0030520 ! estrogen receptor signaling pathway

[Term]
id: GO:0033149
name: FFAT motif binding
namespace: molecular_function
def: "Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0033150
name: cytoskeletal calyx
namespace: cellular_component
def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0033011 ! perinuclear theca

[Term]
id: GO:0033151
name: V(D)J recombination
namespace: biological_process
def: "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149]
synonym: "V(D)J joining" EXACT []
synonym: "V-D-J joining" EXACT []
synonym: "V-D-J recombination" EXACT []
synonym: "V-J joining" EXACT []
synonym: "V-J recombination" EXACT []
xref: Wikipedia:V(D)J_recombination
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus

[Term]
id: GO:0033152
name: immunoglobulin V(D)J recombination
namespace: biological_process
def: "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." [GOC:add, ISBN:0781735149]
synonym: "immunoglobulin V(D)J joining" EXACT [GOC:add]
synonym: "immunoglobulin V-D-J joining" NARROW [GOC:add]
synonym: "immunoglobulin V-D-J recombination" NARROW [GOC:add]
synonym: "immunoglobulin V-J joining" NARROW [GOC:add]
synonym: "immunoglobulin V-J recombination" NARROW [GOC:add]
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments
is_a: GO:0033151 ! V(D)J recombination

[Term]
id: GO:0033153
name: T cell receptor V(D)J recombination
namespace: biological_process
def: "The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221]
synonym: "T cell receptor V(D)J joining" EXACT [GOC:add]
synonym: "T cell receptor V-D-J joining" NARROW [GOC:add]
synonym: "T cell receptor V-D-J recombination" NARROW [GOC:add]
synonym: "T cell receptor V-J joining" NARROW [GOC:add]
synonym: "T cell receptor V-J recombination" NARROW [GOC:add]
synonym: "T-cell receptor V(D)J recombination" EXACT [GOC:add]
synonym: "TCR V(D)J recombination" EXACT [GOC:add]
is_a: GO:0002681 ! somatic recombination of T cell receptor gene segments
is_a: GO:0033151 ! V(D)J recombination

[Term]
id: GO:0033154
name: ABC-type oligogalacturonide transporter activity
namespace: molecular_function
alt_id: GO:0033155
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg, PMID:11555291, PMID:17451747]
synonym: "ATP-dependent oligogalacturonide transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled oligogalacturonide transmembrane transporter activity" RELATED []
synonym: "oligogalacturonide transmembrane transporter activity" NARROW []
synonym: "oligogalacturonide transporting ATPase activity" RELATED []
synonym: "oligogalacturonide-transporting ATPase activity" EXACT []
xref: TC:3.A.1.1.11
is_a: GO:0015422 ! ABC-type oligosaccharide transporter activity

[Term]
id: GO:0033156
name: oligogalacturonide transport
namespace: biological_process
def: "The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0033157
name: regulation of intracellular protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051223 ! regulation of protein transport
relationship: regulates GO:0006886 ! intracellular protein transport

[Term]
id: GO:0033158
name: obsolete regulation of protein import into nucleus, translocation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used.
synonym: "regulation of protein import into cell nucleus, translocation" EXACT []
is_obsolete: true

[Term]
id: GO:0033159
name: obsolete negative regulation of protein import into nucleus, translocation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used.
synonym: "negative regulation of protein import into cell nucleus, translocation" EXACT []
is_obsolete: true

[Term]
id: GO:0033160
name: obsolete positive regulation of protein import into nucleus, translocation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used.
synonym: "positive regulation of protein import into cell nucleus, translocation" EXACT []
is_obsolete: true

[Term]
id: GO:0033161
name: mitogen-activated protein kinase kinase kinase kinase binding
namespace: molecular_function
def: "Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah]
synonym: "MAPKKKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0033162
name: melanosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a melanosome." [GOC:mah]
is_a: GO:0090741 ! pigment granule membrane
relationship: part_of GO:0042470 ! melanosome
relationship: part_of GO:0045009 ! chitosome

[Term]
id: GO:0033163
name: microneme membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a microneme." [GOC:mah]
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0020009 ! microneme

[Term]
id: GO:0033164
name: glycolipid 1,6-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage." [GOC:mcc, PMID:16878994, PMID:2644248]
synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.232]
synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.232]
synonym: "GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.232]
synonym: "glycolipid 6-alpha-mannosyltransferase activity" EXACT []
synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" RELATED [EC:2.4.1.232]
xref: EC:2.4.1.232
xref: MetaCyc:2.4.1.232-RXN
is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0033165
name: interphotoreceptor matrix
namespace: cellular_component
def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [PMID:1862095, PMID:2194288]
is_a: GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0033166
name: hyaline layer
namespace: cellular_component
def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [PMID:1721506, PMID:9473317]
is_a: GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0033167
name: ARC complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250]
synonym: "argonaute siRNA chaperone complex" EXACT []
is_a: GO:0031332 ! RNAi effector complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0033168
name: obsolete conversion of ds siRNA to ss siRNA involved in RNA interference
namespace: biological_process
def: "OBSOLETE. The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference." [GOC:mah, PMID:17310250]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "RNA interference, conversion of ds siRNA to ss siRNA" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0004521

[Term]
id: GO:0033169
name: obsolete histone H3-K9 demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0033171
name: obsolete nucleoprotein filament-forming ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament." [GOC:mah, GOC:vw]
comment: This term was made obsolete because nucleoprotein filament formation does not require ATP hydrolysis, so the term is misleading.
synonym: "nucleoprotein filament-forming ATPase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0033172
name: gas vesicle shell
namespace: cellular_component
def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd]
synonym: "gas vesicle membrane" RELATED []
synonym: "gas vesicle wall" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031411 ! gas vesicle

[Term]
id: GO:0033173
name: calcineurin-NFAT signaling cascade
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]
synonym: "calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "calcineurin-NFAT signalling pathway" RELATED []
is_a: GO:0097720 ! calcineurin-mediated signaling

[Term]
id: GO:0033174
name: obsolete chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)
namespace: cellular_component
def: "OBSOLETE. The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT []
is_obsolete: true
replaced_by: GO:0045261

[Term]
id: GO:0033175
name: obsolete chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)
namespace: cellular_component
def: "OBSOLETE. All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT []
synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT []
is_obsolete: true
replaced_by: GO:0045263

[Term]
id: GO:0033176
name: proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]
synonym: "hydrogen-translocating V-type ATPase complex" EXACT []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
is_a: GO:0090533 ! cation-transporting ATPase complex
is_a: GO:1904949 ! ATPase complex

[Term]
id: GO:0033177
name: proton-transporting two-sector ATPase complex, proton-transporting domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033178
name: proton-transporting two-sector ATPase complex, catalytic domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033179
name: proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain
relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex

[Term]
id: GO:0033180
name: proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain
relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex

[Term]
id: GO:0033181
name: plasma membrane proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT []
is_a: GO:0033176 ! proton-transporting V-type ATPase complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0033182
name: obsolete regulation of histone ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0033183
name: obsolete negative regulation of histone ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0033184
name: obsolete positive regulation of histone ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0033185
name: dolichol-phosphate-mannose synthase complex
namespace: cellular_component
def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346]
synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT []
synonym: "DPM synthase complex" EXACT []
is_a: GO:0031501 ! mannosyltransferase complex

[Term]
id: GO:0033186
name: CAF-1 complex
namespace: cellular_component
def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276]
comment: In yeast the subunits are MSI1/p50, CAC2/p60 and CAC1/p90.
synonym: "chromatin assembly factor 1 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0033187
name: obsolete inositol hexakisphosphate 4-kinase or 6-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "inositol hexakisphosphate 4-kinase or 6-kinase activity" EXACT []
is_obsolete: true
consider: GO:0000830
consider: GO:0000831

[Term]
id: GO:0033188
name: sphingomyelin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin." [EC:2.7.8.27, RHEA:18765]
synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" RELATED [EC:2.7.8.27]
synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" RELATED [EC:2.7.8.27]
synonym: "SM synthase activity" RELATED [EC:2.7.8.27]
synonym: "SMS1" RELATED [EC:2.7.8.27]
synonym: "SMS2" RELATED [EC:2.7.8.27]
xref: EC:2.7.8.27
xref: KEGG_REACTION:R08969
xref: MetaCyc:2.7.8.27-RXN
xref: Reactome:R-HSA-429786 "SGMS2 transfers phosphocholine onto ceramide"
xref: Reactome:R-HSA-429798 "SGMS1 transfers phosphocholine onto ceramide"
xref: RHEA:18765
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0033189
name: response to vitamin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:sl]
synonym: "response to retinol" NARROW []
is_a: GO:0033273 ! response to vitamin
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0033190
name: solanapyrone synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0033191
name: macrophomate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [GOC:cb, PMID:10984474]
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0033192
name: calmodulin-dependent protein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118]
synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED []
synonym: "calcineurin activity" NARROW []
synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT []
synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT []
xref: Reactome:R-HSA-2730849 "Calcineurin binds and dephosphorylates NFAT"
xref: Reactome:R-HSA-4551451 "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling"
is_a: GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity

[Term]
id: GO:0033193
name: Lsd1/2 complex
namespace: cellular_component
def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621]
synonym: "SAPHIRE complex" EXACT [PMID:17371846]
synonym: "Swm complex" EXACT [PMID:17440621]
synonym: "Swm1/2 complex" RELATED [PMID:17440621]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0033194
name: response to hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah]
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033195
name: response to alkyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah]
is_a: GO:0033194 ! response to hydroperoxide

[Term]
id: GO:0033196
name: tryparedoxin peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O." [GOC:mah, PMID:32388269]
synonym: "TXNPx activity" EXACT []
xref: MetaCyc:1.11.1.15-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0033197
name: response to vitamin E
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:sl]
synonym: "response to DL-alpha-tocopherol acetate" NARROW []
synonym: "response to DL-alpha-tocopheryl acetate" NARROW []
synonym: "response to O-Acetyl-alpha-tocopherol" NARROW []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033198
name: response to ATP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl]
synonym: "response to adenosine 5'-triphosphate" EXACT []
synonym: "response to adenosine triphosphate" EXACT []
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033199
name: obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "inositol heptakisphosphate 4-kinase or 6-kinase activity" EXACT []
is_obsolete: true
consider: GO:0000833
consider: GO:0000834

[Term]
id: GO:0033200
name: diphosphoinositol pentakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = ADP + 4,5-bisdiphosphoinositol-1D-myo-inositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = ADP + 5,6-bisdiphosphoinositol-1D-myo-inositol (1,2,3,4)tetrakisphosphate." [PMID:17412958]
synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT []
synonym: "inositol heptakisphosphate 5-kinase activity" EXACT []
synonym: "IP7 5-kinase activity" EXACT []
is_a: GO:0000829 ! diphosphoinositol pentakisphosphate kinase activity

[Term]
id: GO:0033201
name: obsolete alpha-1,4-glucan synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966]
comment: The reason for obsoletion is that this term is equivalent to GO:0033840 alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity.
synonym: "1,4-alpha-glucan synthase activity" EXACT []
is_obsolete: true
replaced_by: GO:0033840

[Term]
id: GO:0033202
name: DNA helicase complex
namespace: cellular_component
def: "A protein complex that possesses DNA helicase activity." [GOC:mah]
subset: goslim_metagenomics
subset: goslim_pir
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0033203
name: DNA helicase A complex
namespace: cellular_component
def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0033204
name: ribonuclease P RNA binding
namespace: molecular_function
def: "Binding to RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963]
synonym: "RNase P RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0033206
name: meiotic cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cytokinesis after meiosis" EXACT []
is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0033207
name: obsolete beta-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah]
comment: This term was obsoleted because it represents the same reaction as N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity ; GO:0033842.
synonym: "beta-1,4-GalNAc transferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0033842

[Term]
id: GO:0033208
name: obsolete UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623]
comment: This term was obsoleted because it represents a specific substrate of N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity ; GO:0033842.
synonym: "Sda beta 1,4GalNAc transferase" RELATED []
synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0033842

[Term]
id: GO:0033209
name: tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "TNF-alpha-mediated signaling pathway" NARROW []
synonym: "tumor necrosis factor alpha-mediated signaling pathway" NARROW []
synonym: "tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071356 ! cellular response to tumor necrosis factor

[Term]
id: GO:0033210
name: leptin-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body." [GOC:mah, GOC:signaling, GOC:yaf]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "leptin-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0044320 ! cellular response to leptin stimulus

[Term]
id: GO:0033211
name: adiponectin-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:20536390]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "adiponectin-mediated signaling pathway" RELATED []
synonym: "adiponectin-mediated signalling pathway" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0033212
name: iron import into cell
namespace: biological_process
alt_id: GO:0070627
def: "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [PMID:18622392, PMID:23192658, Wikipedia:Human_iron_metabolism]
synonym: "ferrous ion import" NARROW []
synonym: "ferrous iron import" NARROW []
synonym: "ferrous iron uptake" NARROW []
synonym: "iron assimilation" RELATED []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0006879 ! intracellular iron ion homeostasis
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0033214
name: siderophore-dependent iron import into cell
namespace: biological_process
alt_id: GO:0015688
alt_id: GO:0033213
def: "A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors." [GOC:mah, PMID:16963626]
synonym: "iron assimilation by capture and transport" RELATED []
synonym: "iron assimilation by chelation and transport" EXACT []
synonym: "iron chelate transport" BROAD []
is_a: GO:0033212 ! iron import into cell
is_a: GO:0098657 ! import into cell
is_a: GO:1901678 ! iron coordination entity transport

[Term]
id: GO:0033215
name: reductive iron assimilation
namespace: biological_process
def: "A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins." [GOC:cjm, GOC:mah, PMID:16963626]
synonym: "iron assimilation by reduction and transport" EXACT []
is_a: GO:0033212 ! iron import into cell

[Term]
id: GO:0033217
name: obsolete regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
namespace: biological_process
def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT []
is_obsolete: true
consider: GO:0006357
consider: GO:0010106

[Term]
id: GO:0033218
name: amide binding
namespace: molecular_function
def: "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0033219
name: urea binding
namespace: molecular_function
def: "Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [GOC:mah, ISBN:0198506732]
is_a: GO:0033218 ! amide binding
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0033220
name: obsolete ATPase-coupled amide-transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "amide-transporting ATPase activity" EXACT []
synonym: "ATP-dependent amide-transporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0033221
name: ATPase-coupled urea transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg]
synonym: "ATP-dependent urea transmembrane transporter activity" EXACT []
synonym: "carbamide-transporting ATPase activity" EXACT []
synonym: "urea-transporting ATPase activity" EXACT []
xref: RHEA:32803
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0033222
name: xylose binding
namespace: molecular_function
def: "Binding to the D- or L-enantiomer of xylose." [GOC:mah]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0033223
name: 2-aminoethylphosphonate transport
namespace: biological_process
def: "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
synonym: "2-phosphonoethylamine transport" EXACT []
synonym: "ciliatine transport" EXACT []
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0033225
name: ATPase-coupled 2-aminoethylphosphonate transporter activity
namespace: molecular_function
alt_id: GO:0033224
def: "Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg]
comment: There is no annotated example of this MF; therefore we cannot classify it more precisely.
synonym: "2-aminoethylphosphonate transmembrane transporter activity" RELATED []
synonym: "2-aminoethylphosphonate transporting ATPase activity" RELATED []
synonym: "2-aminoethylphosphonate-transporting ATPase activity" EXACT []
synonym: "2-phosphonoethylamine transmembrane transporter activity" RELATED []
synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT []
synonym: "ATP-dependent 2-aminoethylphosphonate transporter activity" EXACT []
synonym: "ciliatine transporter activity" RELATED []
synonym: "ciliatine transportingATPase activity" EXACT []
xref: RHEA:32775
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0033226
name: 2-aminoethylphosphonate binding
namespace: molecular_function
def: "Binding to 2-aminoethylphosphonate." [GOC:mlg]
synonym: "2-phosphonoethylamine binding" EXACT []
synonym: "ciliatine binding" EXACT []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0033227
name: dsRNA transport
namespace: biological_process
def: "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0033228
name: cysteine export across plasma membrane
namespace: biological_process
def: "The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mlg]
synonym: "cysteine export" BROAD []
is_a: GO:0032973 ! amino acid export across plasma membrane
is_a: GO:1903712 ! cysteine transmembrane transport

[Term]
id: GO:0033229
name: cysteine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cysteine from one side of a membrane to the other." [GOC:mah]
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity

[Term]
id: GO:0033230
name: ABC-type cysteine transporter activity
namespace: molecular_function
alt_id: GO:0032519
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-cysteine(in) = ADP + H+ + L-cysteine(out) + phosphate." [PMID:25837721, PMID:32144203, RHEA:29783]
synonym: "ATP-dependent cysteine transporter activity" EXACT []
synonym: "ATPase-coupled cysteine transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled cysteine transporter activity" RELATED []
synonym: "cysteine exporter" RELATED []
synonym: "cysteine-exporting ATPase activity" RELATED []
synonym: "cysteine-transporting ATPase activity" EXACT []
xref: MetaCyc:RXN0-3
xref: RHEA:29783
is_a: GO:0015424 ! ABC-type amino acid transporter activity
is_a: GO:0033229 ! cysteine transmembrane transporter activity
is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity

[Term]
id: GO:0033231
name: carbohydrate export
namespace: biological_process
def: "The directed movement of carbohydrates out of a cell or organelle." [GOC:mlg]
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0033232
name: ABC-type D-methionine transporter activity
namespace: molecular_function
alt_id: GO:0032521
alt_id: GO:0032522
alt_id: GO:0048474
alt_id: GO:1901243
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg, PMID:12169620, PMID:12819857, PMID:18621668, RHEA:29767]
synonym: "ATP-dependent D-methionine transporter activity" RELATED []
synonym: "ATP-dependent methionine transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled D-methionine transporter activity" RELATED []
synonym: "ATPase-coupled methionine transmembrane transporter activity" RELATED []
synonym: "D-methionine exporter" RELATED []
synonym: "D-methionine importer" RELATED []
synonym: "D-methionine transmembrane transporter activity" RELATED []
synonym: "D-methionine transporter activity" RELATED []
synonym: "D-methionine-exporting ATPase activity" RELATED []
synonym: "D-methionine-importing ATPase activity" RELATED []
synonym: "D-methionine-transporting ATPase activity" RELATED []
synonym: "methionine transmembrane-transporting ATPase activity" RELATED []
xref: EC:7.4.2.11
xref: MetaCyc:TRANS-RXN0-202
xref: RHEA:29767
is_a: GO:0015424 ! ABC-type amino acid transporter activity
is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity
is_a: GO:0043865 ! methionine transmembrane transporter activity

[Term]
id: GO:0033233
name: regulation of protein sumoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]
synonym: "regulation of sumoylation" EXACT []
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033234
name: negative regulation of protein sumoylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]
synonym: "negative regulation of sumoylation" EXACT []
is_a: GO:0033233 ! regulation of protein sumoylation
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
relationship: negatively_regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033235
name: positive regulation of protein sumoylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]
synonym: "positive regulation of sumoylation" EXACT []
is_a: GO:0033233 ! regulation of protein sumoylation
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
relationship: positively_regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033236
name: obsolete 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036]
synonym: "11-beta-hydroxysteroid dehydrogenase (NAD+) activity" EXACT []
is_obsolete: true
replaced_by: GO:0070523

[Term]
id: GO:0033237
name: obsolete 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146]
synonym: "11-beta-hydroxysteroid dehydrogenase (NADP+) activity" EXACT []
synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" RELATED [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-beta-dehydrogenase activity" RELATED [EC:1.1.1.146]
is_obsolete: true
replaced_by: GO:0070524

[Term]
id: GO:0033238
name: regulation of amine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah]
synonym: "regulation of amine metabolism" EXACT []
synonym: "regulation of cellular amine metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0009308 ! amine metabolic process

[Term]
id: GO:0033239
name: negative regulation of amine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "negative regulation of amine metabolism" EXACT []
synonym: "negative regulation of cellular amine metabolic process" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
relationship: negatively_regulates GO:0009308 ! amine metabolic process

[Term]
id: GO:0033240
name: positive regulation of amine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "positive regulation of amine metabolism" EXACT []
synonym: "positive regulation of cellular amine metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
relationship: positively_regulates GO:0009308 ! amine metabolic process

[Term]
id: GO:0033241
name: regulation of amine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "regulation of amine breakdown" EXACT []
synonym: "regulation of amine catabolism" EXACT []
synonym: "regulation of amine degradation" EXACT []
synonym: "regulation of cellular amine catabolic process" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
relationship: regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033242
name: negative regulation of amine catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "negative regulation of amine breakdown" EXACT []
synonym: "negative regulation of amine catabolism" EXACT []
synonym: "negative regulation of amine degradation" EXACT []
synonym: "negative regulation of cellular amine catabolic process" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0033241 ! regulation of amine catabolic process
relationship: negatively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033243
name: positive regulation of amine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "positive regulation of amine breakdown" EXACT []
synonym: "positive regulation of amine catabolism" EXACT []
synonym: "positive regulation of amine degradation" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0033241 ! regulation of amine catabolic process
relationship: positively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033244
name: regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "regulation of penicillin metabolism" EXACT []
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033245
name: negative regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "negative regulation of penicillin metabolism" EXACT []
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033246
name: positive regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "positive regulation of penicillin metabolism" EXACT []
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033247
name: regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "regulation of penicillin breakdown" EXACT []
synonym: "regulation of penicillin catabolism" EXACT []
synonym: "regulation of penicillin degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
relationship: regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033248
name: negative regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "negative regulation of penicillin breakdown" EXACT []
synonym: "negative regulation of penicillin catabolism" EXACT []
synonym: "negative regulation of penicillin degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0033245 ! negative regulation of penicillin metabolic process
is_a: GO:0033247 ! regulation of penicillin catabolic process
relationship: negatively_regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033249
name: positive regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "positive regulation of penicillin breakdown" EXACT []
synonym: "positive regulation of penicillin catabolism" EXACT []
synonym: "positive regulation of penicillin degradation" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0033246 ! positive regulation of penicillin metabolic process
is_a: GO:0033247 ! regulation of penicillin catabolic process
relationship: positively_regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033250
name: obsolete penicillinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg]
comment: This term was obsoleted because it represents a specific substrate of beta-lactamase activity ; GO:0008800.
is_obsolete: true
replaced_by: GO:0008800

[Term]
id: GO:0033251
name: obsolete cephalosporinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg]
comment: This term was obsoleted because it represents a specific substrate of beta-lactamase activity ; GO:0008800.
is_obsolete: true
replaced_by: GO:0008800

[Term]
id: GO:0033252
name: regulation of beta-lactamase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0033253
name: obsolete regulation of penicillinase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0033254
name: vacuolar transporter chaperone complex
namespace: cellular_component
def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729, PMID:34544285]
synonym: "VTC complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0033255
name: SAS acetyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653]
synonym: "SAS-I complex" EXACT []
is_a: GO:0032777 ! piccolo histone acetyltransferase complex

[Term]
id: GO:0033256
name: I-kappaB/NF-kappaB complex
namespace: cellular_component
def: "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099]
subset: goslim_pir
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0033257
name: Bcl3/NF-kappaB2 complex
namespace: cellular_component
def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099]
synonym: "Bcl3-NFKB2 complex" RELATED []
synonym: "Bcl3-p52 complex" EXACT []
is_a: GO:0033256 ! I-kappaB/NF-kappaB complex

[Term]
id: GO:0033258
name: plastid DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving plastid DNA." [GOC:mah]
synonym: "plastid DNA metabolism" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0009657 ! plastid organization

[Term]
id: GO:0033259
name: plastid DNA replication
namespace: biological_process
def: "The process in which new strands of DNA are synthesized in a plastid." [GOC:mah]
synonym: "plastid DNA synthesis" RELATED []
synonym: "replication of plastid DNA" EXACT []
is_a: GO:0006261 ! DNA-templated DNA replication
is_a: GO:0033258 ! plastid DNA metabolic process

[Term]
id: GO:0033260
name: nuclear DNA replication
namespace: biological_process
def: "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]
synonym: "DNA replication during S phase" RELATED [GOC:dph, GOC:tb]
synonym: "DNA replication involved in S phase" EXACT []
synonym: "DNA replication involved in S-phase" EXACT []
synonym: "nuclear cell cycle DNA replication" EXACT []
is_a: GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:0033261
name: obsolete regulation of S phase
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because cell cycle phases are intervals and so cannot be regulated as such, rather it is the transitions between the phases that are regulated. This term was often also used to annotate genes which should have been annotated to 'regulation of DNA replication', or one of its children.
synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of S phase" EXACT []
synonym: "regulation of S-phase" EXACT []
is_obsolete: true
consider: GO:0044770

[Term]
id: GO:0033262
name: regulation of nuclear cell cycle DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]
synonym: "regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of DNA replication involved in S phase" EXACT []
synonym: "regulation of DNA replication involved in S-phase" EXACT []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
relationship: regulates GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0033263
name: CORVET complex
namespace: cellular_component
def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]
is_a: GO:0099023 ! vesicle tethering complex
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0033264
name: obsolete bontoxilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "BoNT" RELATED []
synonym: "bontoxilysin activity" EXACT []
synonym: "botulinum neurotoxin activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0033265
name: choline binding
namespace: molecular_function
def: "Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [GOC:mlg]
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0033266
name: ABC-type choline transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane." [GOC:mlg]
synonym: "ABC-type choline transmembrane transporter activity" EXACT []
synonym: "ATP-dependent choline transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled choline transmembrane transporter activity" RELATED []
synonym: "choline-transporting ATPase activity" RELATED []
is_a: GO:0015220 ! choline transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0033267
name: obsolete axon part
namespace: cellular_component
def: "OBSOLETE. A part of an axon, a cell projection of a neuron." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0030424

[Term]
id: GO:0033268
name: node of Ranvier
namespace: cellular_component
def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh]
synonym: "node of Ranvier axon" RELATED [NIF_Subcellular:sao188049490]
xref: NIF_Subcellular:birnlex_1152_2
xref: Wikipedia:Nodes_of_Ranvier
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033269
name: internode region of axon
namespace: cellular_component
def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh]
synonym: "internode" EXACT []
xref: NIF_Subcellular:sao206157942
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033270
name: paranode region of axon
namespace: cellular_component
def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858]
synonym: "paranode" EXACT []
xref: NIF_Subcellular:sao234066064
xref: NIF_Subcellular:sao936144858
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033271
name: myo-inositol phosphate transport
namespace: biological_process
def: "The directed movement of any phosphorylated myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0033272
name: myo-inositol hexakisphosphate transport
namespace: biological_process
def: "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "phytate transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0033271 ! myo-inositol phosphate transport

[Term]
id: GO:0033273
name: response to vitamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl]
is_a: GO:0007584 ! response to nutrient

[Term]
id: GO:0033274
name: response to vitamin B2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:sl]
synonym: "response to riboflavin" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033275
name: actin-myosin filament sliding
namespace: biological_process
def: "The sliding movement of actin thin filaments and myosin thick filaments past each other." [GOC:pf]
synonym: "actin filament sliding" RELATED []
is_a: GO:0070252 ! actin-mediated cell contraction

[Term]
id: GO:0033276
name: transcription factor TFTC complex
namespace: cellular_component
def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525]
is_a: GO:0070461 ! SAGA-type complex
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme

[Term]
id: GO:0033277
name: obsolete abortive mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
synonym: "abortive mitosis" RELATED []
is_obsolete: true

[Term]
id: GO:0033278
name: cell proliferation in midbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf]
synonym: "cell proliferation in mesencephalon" EXACT []
synonym: "mesencepahalic cell proliferation" RELATED []
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:0033280
name: response to vitamin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:sl]
synonym: "response to calciferol" EXACT []
synonym: "response to cholecalciferol" NARROW []
synonym: "response to ergocalciferol" NARROW []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033281
name: TAT protein transport complex
namespace: cellular_component
def: "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins." [GOC:pamgo_curators]
synonym: "TAT protein secretion complex" NARROW []
synonym: "TAT protein translocation system complex" NARROW []
synonym: "Twin-arginine translocation complex" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0033282
name: protein C inhibitor-acrosin complex
namespace: cellular_component
def: "A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin." [GOC:pr, PMID:11120760, PMID:7521127]
synonym: "PCI-ACR complex" EXACT [PR:000003652, PR:000014685]
synonym: "PCI-acrosin complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-acrosin complex" EXACT [PR:000014685]
synonym: "serpin A5-acrosin complex" EXACT [PR:000014685]
synonym: "SERPINA5-acrosin complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0033283
name: ATPase-coupled organic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an organic acid from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg]
synonym: "ATP-dependent organic acid transmembrane transporter activity" EXACT []
synonym: "organic acid-transporting ATPase activity" EXACT []
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0033284
name: ATPase-coupled carboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg]
synonym: "ATP-dependent carboxylic acid transporter activity" EXACT []
synonym: "carboxylic acid-transporting ATPase activity" EXACT []
is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0033285
name: ATPase-coupled monocarboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg]
synonym: "ATP-dependent monocarboxylic acid transmembrane transporter activity" EXACT []
synonym: "monocarboxylic acid-transporting ATPase activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity

[Term]
id: GO:0033286
name: ATPase-coupled ectoine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0051471
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg, RHEA:32787]
synonym: "ATP-dependent ectoine transmembrane transporter activity" EXACT []
synonym: "ectoine transmembrane transporter activity" BROAD []
synonym: "ectoine-transporting ATPase activity" EXACT []
xref: RHEA:32787
is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0033288
name: ATPase-coupled hydroxyectoine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0033287
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg]
synonym: "ATP-dependent hydroxyectoine transmembrane transporter activity" EXACT []
synonym: "hydroxyectoine transmembrane transporter activity" BROAD []
synonym: "hydroxyectoine-transporting ATPase activity" EXACT []
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0033289
name: intraconoid microtubule
namespace: cellular_component
def: "A microtubule located such that it threads through the conoid and projects through the polar ring." [GOC:mah, PMID:11901169, PMID:16518471]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0033290
name: eukaryotic 48S preinitiation complex
namespace: cellular_component
alt_id: GO:0016283
def: "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC." [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639]
synonym: "eukaryotic 48S initiation complex" RELATED []
synonym: "eukaryotic 48S pre-initiation complex" EXACT []
is_a: GO:0070993 ! translation preinitiation complex

[Term]
id: GO:0033291
name: eukaryotic 80S initiation complex
namespace: cellular_component
def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049]
is_a: GO:0070992 ! translation initiation complex

[Term]
id: GO:0033292
name: T-tubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:dph, GOC:jl, GOC:mah]
synonym: "T-tubule organisation" EXACT [GOC:mah]
synonym: "T-tubule organization and biogenesis" RELATED [GOC:mah]
synonym: "transverse tubule organization" EXACT [GOC:rl]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0007009 ! plasma membrane organization
relationship: part_of GO:0055001 ! muscle cell development

[Term]
id: GO:0033293
name: monocarboxylic acid binding
namespace: molecular_function
def: "Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah]
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0033294
name: ectoine binding
namespace: molecular_function
def: "Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0033295
name: hydroxyectoine binding
namespace: molecular_function
def: "Binding to hydroxyectoine." [GOC:mlg]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0043178 ! alcohol binding
is_a: GO:0050997 ! quaternary ammonium group binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0033296
name: rhamnose binding
namespace: molecular_function
def: "Binding to the D- or L-enantiomer of rhamnose." [GOC:mah]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0033298
name: contractile vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores." [GOC:mah]
synonym: "contractile vacuole organisation" EXACT [GOC:mah]
synonym: "contractile vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0016050 ! vesicle organization

[Term]
id: GO:0033299
name: secretion of lysosomal enzymes
namespace: biological_process
def: "The controlled release of lysosomal enzymes by a cell." [GOC:mah]
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0033300
name: dehydroascorbic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other." [GOC:go_curators]
synonym: "dehydroascorbate transporter activity" EXACT []
synonym: "dehydroascorbic acid transporter activity" RELATED []
xref: Reactome:R-HSA-198818 "SLC2A1,3 transports DeHA from extracellular region to cytosol"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0033301
name: cell cycle comprising mitosis without cytokinesis
namespace: biological_process
def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah]
comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers.
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0033302
name: quercetin O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [GOC:mah]
synonym: "quercetin O-glucoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0051552 ! flavone metabolic process

[Term]
id: GO:0033303
name: quercetin O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin." [GOC:mah, MetaCyc:PWY-5321]
synonym: "quercetin O-glucoside anabolism" EXACT []
synonym: "quercetin O-glucoside biosynthesis" EXACT []
synonym: "quercetin O-glucoside formation" EXACT []
synonym: "quercetin O-glucoside synthesit" EXACT []
xref: MetaCyc:PWY-5321
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0033302 ! quercetin O-glucoside metabolic process
is_a: GO:0051553 ! flavone biosynthetic process

[Term]
id: GO:0033304
name: chlorophyll a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyll a." [GOC:mah]
synonym: "chlorophyll a metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0033305
name: chlorophyll a biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a." [GOC:mah]
synonym: "chlorophyll a anabolism" EXACT []
synonym: "chlorophyll a biosynthesis" EXACT []
synonym: "chlorophyll a formation" EXACT []
synonym: "chlorophyll a synthesis" EXACT []
is_a: GO:0015995 ! chlorophyll biosynthetic process
is_a: GO:0033304 ! chlorophyll a metabolic process

[Term]
id: GO:0033306
name: phytol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah]
synonym: "phytol metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:0033307
name: phytol salvage
namespace: biological_process
def: "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis." [GOC:mah, MetaCyc:PWY-5107]
synonym: "phytol salvage pathway" EXACT []
xref: MetaCyc:PWY-5107
is_a: GO:0033520 ! phytol biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0033308
name: hydroxyectoine transmembrane transport
namespace: biological_process
def: "The directed movement of hydroxyectoine across a membrane by means of some agent such as a transporter or a pore." [GOC:mlg]
synonym: "hydroxyectoine transport" RELATED []
is_a: GO:0015697 ! quaternary ammonium group transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0033309
name: SBF transcription complex
namespace: cellular_component
def: "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:19150335, PMID:7917338]
synonym: "SBF complex" EXACT [GOC:mah]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0033310
name: chlorophyll a catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of chlorophyll a." [GOC:mah]
synonym: "chlorophyll a breakdown" EXACT []
synonym: "chlorophyll a catabolism" EXACT []
synonym: "chlorophyll a degradation" EXACT []
xref: MetaCyc:PWY-5098
is_a: GO:0015996 ! chlorophyll catabolic process
is_a: GO:0033304 ! chlorophyll a metabolic process

[Term]
id: GO:0033311
name: chlorophyll a biosynthetic process via phytyl diphosphate
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate." [GOC:mah, MetaCyc:PWY-5086]
synonym: "chlorophyll a anabolism via phytyl diphosphate" EXACT []
synonym: "chlorophyll a biosynthesis via phytyl diphosphate" EXACT []
synonym: "chlorophyll a biosynthetic process via phytyl-PP" EXACT []
synonym: "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP" EXACT []
synonym: "chlorophyll a synthesis via phytyl diphosphate" EXACT []
xref: MetaCyc:PWY-5086
is_a: GO:0033305 ! chlorophyll a biosynthetic process

[Term]
id: GO:0033312
name: chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a." [GOC:mah, MetaCyc:PWY-5064]
synonym: "chlorophyll a anabolism via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a formation via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a synthesis via geranylgeranyl-chlorophyll a" EXACT []
xref: MetaCyc:PWY-5064
is_a: GO:0033305 ! chlorophyll a biosynthetic process

[Term]
id: GO:0033313
name: meiotic cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0072411
def: "A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
synonym: "meiotic cell cycle checkpoint" EXACT []
synonym: "signal transduction involved in meiotic cell cycle checkpoint" EXACT []
is_a: GO:0000075 ! cell cycle checkpoint signaling
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0033314
name: mitotic DNA replication checkpoint signaling
namespace: biological_process
alt_id: GO:0031574
alt_id: GO:0072443
alt_id: GO:0072446
alt_id: GO:0072459
def: "A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle DNA replication checkpoint" EXACT []
synonym: "mitotic DNA replication checkpoint" EXACT []
synonym: "S-M checkpoint" EXACT []
synonym: "S-M DNA replication checkpoint" EXACT []
synonym: "S-phase checkpoint" BROAD []
synonym: "signal transduction involved in mitotic DNA replication checkpoint" NARROW []
synonym: "signal transduction involved in mitotic G2/M transition decatenation checkpoint" RELATED []
synonym: "signal transduction involved in S-M checkpoint" EXACT []
is_a: GO:0000076 ! DNA replication checkpoint signaling
is_a: GO:0044774 ! mitotic DNA integrity checkpoint signaling
is_a: GO:0044818 ! mitotic G2/M transition checkpoint

[Term]
id: GO:0033315
name: meiotic G2/MI DNA replication checkpoint signaling
namespace: biological_process
alt_id: GO:0072440
def: "A signal transduction process that controls the G2/M1 transition of the meiotic cell cycle and prevents the initiation of nuclear division until DNA replication is complete." [GOC:mtg_cell_cycle]
synonym: "meiotic cell cycle DNA replication checkpoint" EXACT []
synonym: "meiotic G2/MI DNA replication checkpoint" EXACT []
synonym: "signal transduction involved in meiotic DNA replication checkpoint" EXACT []
is_a: GO:0000076 ! DNA replication checkpoint signaling
is_a: GO:0044778 ! meiotic DNA integrity checkpoint signaling
is_a: GO:0110031 ! negative regulation of G2/MI transition of meiotic cell cycle

[Term]
id: GO:0033316
name: meiotic spindle assembly checkpoint signaling
namespace: biological_process
alt_id: GO:0072465
def: "A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah]
synonym: "meiotic spindle assembly checkpoint" EXACT []
synonym: "signal transduction involved in meiotic spindle assembly checkpoint" EXACT []
is_a: GO:0044779 ! meiotic spindle checkpoint signaling
is_a: GO:0071173 ! spindle assembly checkpoint signaling

[Term]
id: GO:0033319
name: UDP-D-xylose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-xylose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033320
name: UDP-D-xylose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-4821]
synonym: "UDP-D-xylose anabolism" EXACT []
synonym: "UDP-D-xylose biosynthesis" EXACT []
synonym: "UDP-D-xylose formation" EXACT []
synonym: "UDP-D-xylose synthesis" EXACT []
xref: MetaCyc:PWY-4821
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033319 ! UDP-D-xylose metabolic process

[Term]
id: GO:0033321
name: homomethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah]
synonym: "homomethionine metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0033322
name: L-homomethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-homomethionine, a non-protein amino acid synthesized from L-methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186]
synonym: "homomethionine anabolism" EXACT []
synonym: "homomethionine biosynthesis" EXACT []
synonym: "homomethionine biosynthetic process" EXACT []
synonym: "homomethionine formation" EXACT []
synonym: "homomethionine synthesis" EXACT []
xref: MetaCyc:PWY-1186
is_a: GO:0033321 ! homomethionine metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0033323
name: choline biosynthetic process via CDP-choline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline." [GOC:mah, MetaCyc:PWY-3561]
synonym: "choline anabolism via CDP-choline" EXACT []
synonym: "choline biosynthesis via CDP-choline" EXACT []
synonym: "choline formation via CDP-choline" EXACT []
synonym: "choline synthesis via CDP-choline" EXACT []
xref: MetaCyc:PWY-3561
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033324
name: choline biosynthetic process via N-monomethylethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine." [GOC:mah, MetaCyc:PWY-3542]
synonym: "choline anabolism via N-monomethylethanolamine" EXACT []
synonym: "choline biosynthesis via N-monomethylethanolamine" EXACT []
synonym: "choline formation via N-monomethylethanolamine" EXACT []
synonym: "choline synthesis via N-monomethylethanolamine" EXACT []
xref: MetaCyc:PWY-3542
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033325
name: choline biosynthetic process via phosphoryl-ethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine." [GOC:mah, MetaCyc:PWY-3385]
synonym: "choline anabolism via phosphoryl-ethanolamine" EXACT []
synonym: "choline biosynthesis via phosphoryl-ethanolamine" EXACT []
synonym: "choline formation via phosphoryl-ethanolamine" EXACT []
synonym: "choline synthesis via phosphoryl-ethanolamine" EXACT []
xref: MetaCyc:PWY-3385
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033326
name: cerebrospinal fluid secretion
namespace: biological_process
def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, PMID:10716451]
synonym: "CSF secretion" EXACT []
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0033327
name: Leydig cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0033328
name: peroxisome membrane targeting sequence binding
namespace: molecular_function
def: "Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130, PMID:17020786]
synonym: "mPTS binding" EXACT []
synonym: "peroxisomal membrane protein (PMP) targeting signal (mPTS) binding" EXACT [PMID:14709540]
synonym: "PMP targeting signal (mPTS) binding" EXACT [PMID:14709540]
synonym: "PMP targeting signal binding" EXACT [PMID:14709540]
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0033329
name: kaempferol O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah]
synonym: "kaempferol O-glucoside metabolism" EXACT []
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:0033330
name: kaempferol O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320]
synonym: "kaempferol O-glucoside anabolism" EXACT []
synonym: "kaempferol O-glucoside biosynthesis" EXACT []
synonym: "kaempferol O-glucoside formation" EXACT []
synonym: "kaempferol O-glucoside synthesit" EXACT []
xref: MetaCyc:PWY-5320
is_a: GO:0033329 ! kaempferol O-glucoside metabolic process
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0033331
name: ent-kaurene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, PMID:17064690]
synonym: "ent-kaurene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0033332
name: ent-kaurene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]
synonym: "ent-kaurene anabolism" EXACT []
synonym: "ent-kaurene biosynthesis" EXACT []
synonym: "ent-kaurene formation" EXACT []
synonym: "ent-kaurene synthesis" EXACT []
xref: MetaCyc:PWY-5032
is_a: GO:0033331 ! ent-kaurene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0033333
name: fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0033334
name: fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a fin are generated and organized." [GOC:dgh]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0033333 ! fin development

[Term]
id: GO:0033335
name: anal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033336
name: caudal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033337
name: dorsal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033338
name: medial fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure." [GOC:dgh]
synonym: "median fin development" EXACT []
is_a: GO:0033333 ! fin development

[Term]
id: GO:0033339
name: pectoral fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development
is_a: GO:0060173 ! limb development

[Term]
id: GO:0033340
name: pelvic fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development
is_a: GO:0060173 ! limb development

[Term]
id: GO:0033341
name: regulation of collagen binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0033342
name: negative regulation of collagen binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of collagen binding" EXACT []
synonym: "down-regulation of collagen binding" EXACT []
synonym: "downregulation of collagen binding" EXACT []
synonym: "inhibition of collagen binding" NARROW []
is_a: GO:0033341 ! regulation of collagen binding
is_a: GO:0051100 ! negative regulation of binding

[Term]
id: GO:0033343
name: positive regulation of collagen binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of collagen binding" NARROW []
synonym: "stimulation of collagen binding" NARROW []
synonym: "up regulation of collagen binding" EXACT []
synonym: "up-regulation of collagen binding" EXACT []
synonym: "upregulation of collagen binding" EXACT []
is_a: GO:0033341 ! regulation of collagen binding
is_a: GO:0051099 ! positive regulation of binding

[Term]
id: GO:0033344
name: cholesterol efflux
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:sart]
synonym: "cholesterol export" EXACT []
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0033345
name: asparagine catabolic process via L-aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]
xref: MetaCyc:ASPARAGINE-DEG1-PWY
is_a: GO:0006530 ! asparagine catabolic process

[Term]
id: GO:0033346
name: asparagine catabolic process via 2-oxosuccinamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate." [GOC:mah, MetaCyc:PWY-4002]
xref: MetaCyc:PWY-4002
is_a: GO:0006530 ! asparagine catabolic process

[Term]
id: GO:0033347
name: tetrose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah]
synonym: "tetrose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0033348
name: tetrose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah]
synonym: "tetrose anabolism" EXACT []
synonym: "tetrose biosynthesis" EXACT []
synonym: "tetrose formation" EXACT []
synonym: "tetrose synthesis" EXACT []
is_a: GO:0033347 ! tetrose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0033349
name: apiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [GOC:mah]
synonym: "apiose metabolism" EXACT []
is_a: GO:0033347 ! tetrose metabolic process

[Term]
id: GO:0033350
name: apiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [GOC:mah]
synonym: "apiose anabolism" EXACT []
synonym: "apiose biosynthesis" EXACT []
synonym: "apiose formation" EXACT []
synonym: "apiose synthesis" EXACT []
is_a: GO:0033348 ! tetrose biosynthetic process
is_a: GO:0033349 ! apiose metabolic process

[Term]
id: GO:0033351
name: UDP-D-apiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-apiose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033352
name: UDP-D-apiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-5113]
synonym: "UDP-D-apiose anabolism" EXACT []
synonym: "UDP-D-apiose biosynthesis" EXACT []
synonym: "UDP-D-apiose formation" EXACT []
synonym: "UDP-D-apiose synthesis" EXACT []
xref: MetaCyc:PWY-5113
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033351 ! UDP-D-apiose metabolic process

[Term]
id: GO:0033353
name: S-adenosylmethionine cycle
namespace: biological_process
def: "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]
synonym: "activated methyl cycle" EXACT []
synonym: "SAM cycle" EXACT []
xref: MetaCyc:PWY-5041
is_a: GO:0046500 ! S-adenosylmethionine metabolic process

[Term]
id: GO:0033354
name: chlorophyll cycle
namespace: biological_process
def: "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates." [GOC:mah, MetaCyc:PWY-5068]
xref: MetaCyc:PWY-5068
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0033355
name: ascorbate glutathione cycle
namespace: biological_process
def: "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH." [GOC:mah, MetaCyc:PWY-2261]
synonym: "hydrogen peroxide detoxification" RELATED []
xref: MetaCyc:PWY-2261
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042744 ! hydrogen peroxide catabolic process

[Term]
id: GO:0033356
name: UDP-L-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-L-arabinose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033357
name: L-arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose." [GOC:mah]
synonym: "L-arabinose anabolism" EXACT []
synonym: "L-arabinose biosynthesis" EXACT []
synonym: "L-arabinose formation" EXACT []
synonym: "L-arabinose synthesis" EXACT []
is_a: GO:0019567 ! arabinose biosynthetic process
is_a: GO:0046373 ! L-arabinose metabolic process

[Term]
id: GO:0033358
name: UDP-L-arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-82]
synonym: "UDP-L-arabinose anabolism" EXACT []
synonym: "UDP-L-arabinose biosynthesis" EXACT []
synonym: "UDP-L-arabinose formation" EXACT []
synonym: "UDP-L-arabinose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033356 ! UDP-L-arabinose metabolic process

[Term]
id: GO:0033359
name: lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY]
synonym: "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
xref: MetaCyc:DAPLYSINESYN-PWY
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033360
name: lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:PWY-2941]
synonym: "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
xref: MetaCyc:PWY-2941
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033361
name: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step." [GOC:mah, GOC:pr, MetaCyc:PWY-2942]
synonym: "lysine anabolism via diaminopimelate, dehydrogenase pathway" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway" EXACT []
synonym: "lysine formation via diaminopimelate, dehydrogenase pathway" EXACT []
synonym: "lysine synthesis via diaminopimelate, dehydrogenase pathway" EXACT []
xref: MetaCyc:PWY-2942
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033362
name: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps." [GOC:mah, GOC:pr, MetaCyc:PWY-5097]
synonym: "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
xref: MetaCyc:PWY-5097
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033363
name: secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "secretory granule organisation" EXACT [GOC:mah]
synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0033364
name: mast cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "mast cell secretory granule maturation" RELATED []
synonym: "mast cell secretory granule organisation" EXACT [GOC:mah]
synonym: "mast cell secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0033365
name: protein localization to organelle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]
synonym: "protein localisation to organelle" EXACT [GOC:mah]
synonym: "protein localization in organelle" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0033366
name: protein localization to secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah]
synonym: "protein localisation in secretory granule" EXACT [GOC:mah]
synonym: "protein localization in secretory granule" EXACT []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0033367
name: protein localization to mast cell secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "protein localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "protein localization in mast cell secretory granule" EXACT []
is_a: GO:0033366 ! protein localization to secretory granule
relationship: part_of GO:0033364 ! mast cell secretory granule organization

[Term]
id: GO:0033368
name: protease localization to mast cell secretory granule
namespace: biological_process
def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "protease localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "protease localization in mast cell secretory granule" EXACT []
is_a: GO:0033367 ! protein localization to mast cell secretory granule

[Term]
id: GO:0033369
name: establishment of protein localization to mast cell secretory granule
namespace: biological_process
def: "The directed movement of a protein to a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "establishment of protein localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protein localization in mast cell secretory granule" EXACT []
is_a: GO:0006886 ! intracellular protein transport
relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule

[Term]
id: GO:0033370
name: maintenance of protein location in mast cell secretory granule
namespace: biological_process
def: "A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protein localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "mast cell protein retention" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule

[Term]
id: GO:0033371
name: T cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "T cell secretory granule organisation" EXACT [GOC:mah]
synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah]
synonym: "T lymphocyte secretory granule organization" EXACT []
synonym: "T-cell secretory granule organization" EXACT []
synonym: "T-lymphocyte secretory granule maturation" RELATED []
synonym: "T-lymphocyte secretory granule organization" EXACT []
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0033372
name: establishment of protease localization to mast cell secretory granule
namespace: biological_process
def: "The directed movement of a protease to a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "establishment of protease localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protease localization in mast cell secretory granule" EXACT []
is_a: GO:0033369 ! establishment of protein localization to mast cell secretory granule
relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule

[Term]
id: GO:0033373
name: maintenance of protease location in mast cell secretory granule
namespace: biological_process
def: "A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protease localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "mast cell protease retention" EXACT []
is_a: GO:0033370 ! maintenance of protein location in mast cell secretory granule
relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule

[Term]
id: GO:0033374
name: protein localization to T cell secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "protein localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "protein localization in T cell secretory granule" EXACT []
synonym: "protein localization in T lymphocyte secretory granule" EXACT []
synonym: "protein localization in T-cell secretory granule" EXACT []
synonym: "protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033366 ! protein localization to secretory granule
relationship: part_of GO:0033371 ! T cell secretory granule organization

[Term]
id: GO:0033375
name: protease localization to T cell secretory granule
namespace: biological_process
def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "protease localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "protease localization in T cell secretory granule" EXACT []
synonym: "protease localization in T lymphocyte secretory granule" EXACT []
synonym: "protease localization in T-cell secretory granule" EXACT []
synonym: "protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033374 ! protein localization to T cell secretory granule

[Term]
id: GO:0033376
name: establishment of protein localization to T cell secretory granule
namespace: biological_process
def: "The directed movement of a protein to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of protein localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protein localization in T cell secretory granule" EXACT []
synonym: "establishment of protein localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of protein localization in T-cell secretory granule" EXACT []
synonym: "establishment of protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0006886 ! intracellular protein transport
relationship: part_of GO:0033374 ! protein localization to T cell secretory granule

[Term]
id: GO:0033377
name: maintenance of protein location in T cell secretory granule
namespace: biological_process
def: "A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protein localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protein localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of protein localization in T-cell secretory granule" EXACT []
synonym: "maintenance of protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0033374 ! protein localization to T cell secretory granule

[Term]
id: GO:0033378
name: establishment of protease localization to T cell secretory granule
namespace: biological_process
def: "The directed movement of a protease to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of protease localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protease localization in T cell secretory granule" EXACT []
synonym: "establishment of protease localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of protease localization in T-cell secretory granule" EXACT []
synonym: "establishment of protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033376 ! establishment of protein localization to T cell secretory granule
relationship: part_of GO:0033375 ! protease localization to T cell secretory granule

[Term]
id: GO:0033379
name: maintenance of protease location in T cell secretory granule
namespace: biological_process
def: "A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protease localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protease localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of protease localization in T-cell secretory granule" EXACT []
synonym: "maintenance of protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033377 ! maintenance of protein location in T cell secretory granule
relationship: part_of GO:0033375 ! protease localization to T cell secretory granule

[Term]
id: GO:0033380
name: granzyme B localization to T cell secretory granule
namespace: biological_process
def: "Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "granzyme B localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "granzyme B localization in T cell secretory granule" EXACT []
synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "granzyme B localization in T-cell secretory granule" EXACT []
synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033375 ! protease localization to T cell secretory granule

[Term]
id: GO:0033381
name: establishment of granzyme B localization to T cell secretory granule
namespace: biological_process
def: "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of granzyme B localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of granzyme B localization in T cell secretory granule" EXACT []
synonym: "establishment of granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of granzyme B localization in T-cell secretory granule" EXACT []
synonym: "establishment of granzyme B localization in T-lymphocyte secretory granule" EXACT []
synonym: "T-lymphocyte secretory granule storage of granzyme B" RELATED []
is_a: GO:0033378 ! establishment of protease localization to T cell secretory granule
relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule

[Term]
id: GO:0033382
name: maintenance of granzyme B location in T cell secretory granule
namespace: biological_process
def: "A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:mah]
synonym: "maintenance of granzyme B localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of granzyme B localization in T-cell secretory granule" EXACT []
synonym: "maintenance of granzyme B localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033379 ! maintenance of protease location in T cell secretory granule
relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule

[Term]
id: GO:0033383
name: geranyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah]
synonym: "geranyl diphosphate metabolism" EXACT []
synonym: "geranyldiphosphate metabolic process" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0033384
name: geranyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geranyl diphosphate." [GOC:mah, MetaCyc:PWY-5122]
synonym: "geranyl diphosphate anabolism" EXACT []
synonym: "geranyl diphosphate biosynthesis" EXACT []
synonym: "geranyl diphosphate formation" EXACT []
synonym: "geranyl diphosphate synthesis" EXACT []
synonym: "geranyldiphosphate biosynthetic process" EXACT []
xref: MetaCyc:PWY-5122
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033383 ! geranyl diphosphate metabolic process

[Term]
id: GO:0033385
name: geranylgeranyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah]
synonym: "geranylgeranyl diphosphate metabolism" EXACT []
synonym: "geranylgeranyldiphosphate metabolic process" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0033386
name: geranylgeranyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah]
synonym: "geranylgeranyl diphosphate anabolism" EXACT []
synonym: "geranylgeranyl diphosphate biosynthesis" EXACT []
synonym: "geranylgeranyl diphosphate formation" EXACT []
synonym: "geranylgeranyl diphosphate synthesis" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process

[Term]
id: GO:0033387
name: putrescine biosynthetic process from arginine, via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine, via decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]
synonym: "putrescine anabolism from ornithine" EXACT []
synonym: "putrescine biosynthesis from ornithine" EXACT []
synonym: "putrescine biosynthetic process from ornithine" EXACT []
synonym: "putrescine formation from ornithine" EXACT []
synonym: "putrescine synthesis from ornithine" EXACT []
xref: MetaCyc:PWY-46
is_a: GO:0033388 ! putrescine biosynthetic process from arginine

[Term]
id: GO:0033388
name: putrescine biosynthetic process from arginine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah]
synonym: "putrescine anabolism from arginine" EXACT []
synonym: "putrescine biosynthesis from arginine" EXACT []
synonym: "putrescine formation from arginine" EXACT []
synonym: "putrescine synthesis from arginine" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0009446 ! putrescine biosynthetic process

[Term]
id: GO:0033389
name: putrescine biosynthetic process from arginine, via agmatine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine via agmatine." [GOC:mah, MetaCyc:PWY-40]
synonym: "putrescine anabolism from arginine, using agmatinase" EXACT []
synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT []
synonym: "putrescine biosynthetic process from arginine, using agmatinase" EXACT []
synonym: "putrescine formation from arginine, using agmatinase" EXACT []
synonym: "putrescine synthesis from arginine, using agmatinase" EXACT []
xref: MetaCyc:PWY-40
is_a: GO:0033388 ! putrescine biosynthetic process from arginine

[Term]
id: GO:0033390
name: putrescine biosynthetic process from arginine via N-carbamoylputrescine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps." [GOC:mah, MetaCyc:PWY-43]
synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT []
xref: MetaCyc:PWY-43
is_a: GO:0033388 ! putrescine biosynthetic process from arginine

[Term]
id: GO:0033391
name: chromatoid body
namespace: cellular_component
def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363]
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0033392
name: obsolete actin homodimerization activity
namespace: molecular_function
def: "OBSOLETE. Binding to an identical actin monomer to form a homodimer." [GOC:mah]
comment: This term was made obsolete because it was added in error; formation of an actin dimer is simply a transient step in the polymerization of actin. Also, this term may not represent a real molecular function in GO, but rather that a gene product (actin itself) is part of an actin homodimer transient protein complex.
synonym: "actin dimerization activity" BROAD []
synonym: "actin homodimerization activity" EXACT []
synonym: "actin polymerizing activity" RELATED []
is_obsolete: true

[Term]
id: GO:0033393
name: homogalacturonan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:mah]
synonym: "homogalacturonan breakdown" EXACT []
synonym: "homogalacturonan catabolism" EXACT []
synonym: "homogalacturonan degradation" EXACT []
xref: MetaCyc:PWY-1081
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010394 ! homogalacturonan metabolic process

[Term]
id: GO:0033394
name: beta-alanine biosynthetic process via 1,3 diaminopropane
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane." [GOC:mah, MetaCyc:PWY-3981]
synonym: "beta-alanine anabolism via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine biosynthesis via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine formation via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine synthesis via 1,3 diaminopropane" EXACT []
xref: MetaCyc:PWY-3981
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033395
name: beta-alanine biosynthetic process via 3-hydroxypropionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate." [GOC:mah, MetaCyc:PWY-3941]
synonym: "beta-alanine anabolism via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine biosynthesis via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine formation via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine synthesis via 3-hydroxypropionate" EXACT []
xref: MetaCyc:PWY-3941
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033396
name: beta-alanine biosynthetic process via 3-ureidopropionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982]
synonym: "beta-alanine anabolism via 3-ureidopropionate" EXACT []
synonym: "beta-alanine formation via 3-ureidopropionate" EXACT []
synonym: "beta-alanine synthesis via 3-ureidopropionate" EXACT []
xref: MetaCyc:PWY-3982
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033397
name: zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah]
synonym: "zeatin metabolism" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0033398
name: zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah]
synonym: "zeatin anabolism" EXACT []
synonym: "zeatin biosynthesis" EXACT []
synonym: "zeatin formation" EXACT []
synonym: "zeatin synthesis" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0033397 ! zeatin metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0033399
name: cis-zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah]
synonym: "cis-zeatin metabolism" EXACT []
is_a: GO:0033397 ! zeatin metabolic process

[Term]
id: GO:0033400
name: trans-zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah]
synonym: "trans-zeatin metabolism" EXACT []
is_a: GO:0033397 ! zeatin metabolic process

[Term]
id: GO:0033401
name: UUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUU codon." [GOC:mah]
comment: Note that in the standard genetic code, TTT codes for phenylalanine.
synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033402
name: UUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUC codon." [GOC:mah]
comment: Note that in the standard genetic code, TTC codes for phenylalanine.
synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033403
name: UUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUA codon." [GOC:mah]
comment: Note that in the standard genetic code, TTA codes for leucine.
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033404
name: UUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUG codon." [GOC:mah]
comment: Note that in the standard genetic code, TTG codes for leucine.
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033405
name: UCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCU codon." [GOC:mah]
comment: Note that in the standard genetic code, TCT codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033406
name: UCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCC codon." [GOC:mah]
comment: Note that in the standard genetic code, TCC codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033407
name: UCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCA codon." [GOC:mah]
comment: Note that in the standard genetic code, TCA codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033408
name: UCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCG codon." [GOC:mah]
comment: Note that in the standard genetic code, TCG codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033409
name: UAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAU codon." [GOC:mah]
comment: Note that in the standard genetic code, TAT codes for tyrosine.
synonym: "TAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033410
name: UAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAC codon." [GOC:mah]
comment: Note that in the standard genetic code, TAC codes for tyrosine.
synonym: "TAC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033411
name: UAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAA codon." [GOC:mah]
comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA.
synonym: "TAA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033412
name: UAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAG codon." [GOC:mah]
comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA.
synonym: "TAG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033413
name: UGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGU codon." [GOC:mah]
comment: Note that in the standard genetic code, TGT codes for cysteine.
synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033414
name: UGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGC codon." [GOC:mah]
comment: Note that in the standard genetic code, TGC codes for cysteine.
synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TGC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033415
name: UGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGA codon." [GOC:mah]
comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA.
synonym: "TGA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033416
name: UGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGG codon." [GOC:mah]
comment: Note that in the standard genetic code, TGG codes for tryptophan.
synonym: "TGG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tryptophan tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033417
name: CUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUU codon." [GOC:mah]
comment: Note that in the standard genetic code, CTT codes for leucine.
synonym: "CTT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033418
name: CUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUC codon." [GOC:mah]
comment: Note that in the standard genetic code, CTC codes for leucine.
synonym: "CTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033419
name: CUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUA codon." [GOC:mah]
comment: Note that in the standard genetic code, CTA codes for leucine.
synonym: "CTA codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033420
name: CUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUG codon." [GOC:mah]
comment: Note that in the standard genetic code, CTG codes for leucine.
synonym: "CTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033421
name: CCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCU codon." [GOC:mah]
comment: Note that in the standard genetic code, CCT codes for proline.
synonym: "CCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033422
name: CCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah]
comment: Note that in the standard genetic code, CCC codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033423
name: CCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah]
comment: Note that in the standard genetic code, CCA codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033424
name: CCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah]
comment: Note that in the standard genetic code, CCG codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033425
name: CAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAU codon." [GOC:mah]
comment: Note that in the standard genetic code, CAT codes for histidine.
synonym: "CAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033426
name: CAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah]
comment: Note that in the standard genetic code, CAC codes for histidine.
synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033427
name: CAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah]
comment: Note that in the standard genetic code, CAA codes for glutamine.
synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033428
name: CAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah]
comment: Note that in the standard genetic code, CAG codes for glutamine.
synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033429
name: CGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGU codon." [GOC:mah]
comment: Note that in the standard genetic code, CGT codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "CGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033430
name: CGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah]
comment: Note that in the standard genetic code, CGC codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033431
name: CGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah]
comment: Note that in the standard genetic code, CGA codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033432
name: CGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah]
comment: Note that in the standard genetic code, CGG codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033433
name: AUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUU codon." [GOC:mah]
comment: Note that in the standard genetic code, ATT codes for isoleucine.
synonym: "ATT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033434
name: AUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUC codon." [GOC:mah]
comment: Note that in the standard genetic code, ATC codes for isoleucine.
synonym: "ATC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033435
name: AUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUA codon." [GOC:mah]
comment: Note that in the standard genetic code, ATA codes for isoleucine.
synonym: "ATA codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033436
name: AUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUG codon." [GOC:mah]
comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon.
synonym: "ATG codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "initiator methionine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "methionine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033437
name: ACU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACU codon." [GOC:mah]
comment: Note that in the standard genetic code, ACT codes for threonine.
synonym: "ACT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033438
name: ACC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah]
comment: Note that in the standard genetic code, ACC codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033439
name: ACA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah]
comment: Note that in the standard genetic code, ACA codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033440
name: ACG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah]
comment: Note that in the standard genetic code, ACG codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033441
name: AAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAU codon." [GOC:mah]
comment: Note that in the standard genetic code, AAT codes for asparagine.
synonym: "AAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033442
name: AAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah]
comment: Note that in the standard genetic code, AAC codes for asparagine.
synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033443
name: AAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah]
comment: Note that in the standard genetic code, AAA codes for lysine.
synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033444
name: AAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah]
comment: Note that in the standard genetic code, AAG codes for lysine.
synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033445
name: AGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGU codon." [GOC:mah]
comment: Note that in the standard genetic code, AGT codes for serine.
synonym: "AGT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033446
name: AGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah]
comment: Note that in the standard genetic code, AGC codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033447
name: AGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah]
comment: Note that in the standard genetic code, AGA codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033448
name: AGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah]
comment: Note that in the standard genetic code, AGG codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033449
name: GUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUU codon." [GOC:mah]
comment: Note that in the standard genetic code, GTT codes for valine.
synonym: "GTT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033450
name: GUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUC codon." [GOC:mah]
comment: Note that in the standard genetic code, GTC codes for valine.
synonym: "GTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033451
name: GUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUA codon." [GOC:mah]
comment: Note that in the standard genetic code, GTA codes for valine.
synonym: "GTA codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033452
name: GUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUG codon." [GOC:mah]
comment: Note that in the standard genetic code, GTG codes for valine.
synonym: "GTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033453
name: GCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCU codon." [GOC:mah]
comment: Note that in the standard genetic code, GCT codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "GCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033454
name: GCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah]
comment: Note that in the standard genetic code, GCC codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033455
name: GCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah]
comment: Note that in the standard genetic code, GCA codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033456
name: GCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah]
comment: Note that in the standard genetic code, GCG codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033457
name: GAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAU codon." [GOC:mah]
comment: Note that in the standard genetic code, GAT codes for aspartic acid.
synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "GAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033458
name: GAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah]
comment: Note that in the standard genetic code, GAC codes for aspartic acid.
synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033459
name: GAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah]
comment: Note that in the standard genetic code, GAA codes for glutamic acid.
synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033460
name: GAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah]
comment: Note that in the standard genetic code, GAG codes for glutamic acid.
synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033461
name: GGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGU codon." [GOC:mah]
comment: Note that in the standard genetic code, GGT codes for glycine.
synonym: "GGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033462
name: GGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah]
comment: Note that in the standard genetic code, GGC codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033463
name: GGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah]
comment: Note that in the standard genetic code, GGA codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033464
name: GGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah]
comment: Note that in the standard genetic code, GGG codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033465
name: cis-zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah]
synonym: "cis-zeatin anabolism" EXACT []
synonym: "cis-zeatin biosynthesis" EXACT []
synonym: "cis-zeatin formation" EXACT []
synonym: "cis-zeatin synthesis" EXACT []
xref: MetaCyc:PWY-2781
is_a: GO:0033398 ! zeatin biosynthetic process
is_a: GO:0033399 ! cis-zeatin metabolic process

[Term]
id: GO:0033466
name: trans-zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah]
synonym: "trans-zeatin anabolism" EXACT []
synonym: "trans-zeatin biosynthesis" EXACT []
synonym: "trans-zeatin formation" EXACT []
synonym: "trans-zeatin synthesis" EXACT []
xref: MetaCyc:PWY-2681
is_a: GO:0033398 ! zeatin biosynthetic process
is_a: GO:0033400 ! trans-zeatin metabolic process

[Term]
id: GO:0033467
name: CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah]
synonym: "CMP-KDO metabolic process" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT []
synonym: "CMP-ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732]
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033468
name: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-1269]
synonym: "CMP-KDO biosynthesis" EXACT []
synonym: "CMP-KDO biosynthetic process" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid formation" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT []
synonym: "CMP-ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732]
xref: MetaCyc:PWY-1269
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033467 ! CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process

[Term]
id: GO:0033469
name: gibberellin 12 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [GOC:mah]
synonym: "GA12 metabolic process" EXACT []
synonym: "gibberellin 12 metabolism" EXACT []
synonym: "gibberellin A12 metabolic process" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0033470
name: gibberellin 12 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [GOC:mah]
synonym: "GA12 biosynthetic process" EXACT []
synonym: "gibberellin 12 anabolism" EXACT []
synonym: "gibberellin 12 biosynthesis" EXACT []
synonym: "gibberellin 12 formation" EXACT []
synonym: "gibberellin 12 synthesis" EXACT []
synonym: "gibberellin A12 biosynthetic process" EXACT []
xref: MetaCyc:PWY-5034
is_a: GO:0009686 ! gibberellin biosynthetic process
is_a: GO:0033469 ! gibberellin 12 metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0033471
name: GDP-L-galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah]
synonym: "GDP-L-galactose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033472
name: GDP-L-galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah]
synonym: "GDP-L-galactose anabolism" EXACT []
synonym: "GDP-L-galactose biosynthesis" EXACT []
synonym: "GDP-L-galactose formation" EXACT []
synonym: "GDP-L-galactose synthesis" EXACT []
xref: MetaCyc:PWY-5115
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033471 ! GDP-L-galactose metabolic process

[Term]
id: GO:0033473
name: indoleacetic acid conjugate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah]
synonym: "IAA conjugate metabolic process" EXACT []
synonym: "indole acetic acid conjugate metabolic process" EXACT []
synonym: "indole acetic acid conjugate metabolism" EXACT []
synonym: "indoleacetic acid conjugate metabolism" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process

[Term]
id: GO:0033474
name: indoleacetic acid conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah]
synonym: "IAA conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid conjugate biosynthesis" EXACT []
synonym: "indole acetic acid conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid conjugate anabolism" EXACT []
synonym: "indoleacetic acid conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid conjugate formation" EXACT []
synonym: "indoleacetic acid conjugate synthesis" EXACT []
is_a: GO:0009851 ! auxin biosynthetic process
is_a: GO:0033473 ! indoleacetic acid conjugate metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process

[Term]
id: GO:0033475
name: indoleacetic acid amide conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond." [GOC:mah, MetaCyc:PWY-1782]
synonym: "IAA amide conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid amide conjugate biosynthesis" EXACT []
synonym: "indole acetic acid amide conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid amide conjugate anabolism" EXACT []
synonym: "indoleacetic acid amide conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid amide conjugate formation" EXACT []
synonym: "indoleacetic acid amide conjugate synthesis" EXACT []
xref: MetaCyc:PWY-1782
is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0033476
name: indoleacetic acid ester conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond." [GOC:mah, MetaCyc:PWY-1741]
synonym: "IAA ester conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid ester conjugate biosynthesis" EXACT []
synonym: "indole acetic acid ester conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid ester conjugate anabolism" EXACT []
synonym: "indoleacetic acid ester conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid ester conjugate formation" EXACT []
synonym: "indoleacetic acid ester conjugate synthesis" EXACT []
xref: MetaCyc:PWY-1741
is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process

[Term]
id: GO:0033477
name: S-methylmethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [GOC:mah, PMID:12692340]
synonym: "S-methylmethionine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0033478
name: UDP-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [GOC:mah, PMID:15134748]
synonym: "UDP-rhamnose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033479
name: UDP-D-galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-galacturonate metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033480
name: UDP-D-galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-galacturonate anabolism" EXACT []
synonym: "UDP-D-galacturonate biosynthesis" EXACT []
synonym: "UDP-D-galacturonate formation" EXACT []
synonym: "UDP-D-galacturonate synthesis" EXACT []
xref: MetaCyc:PWY-4
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033479 ! UDP-D-galacturonate metabolic process

[Term]
id: GO:0033481
name: galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid." [GOC:mah]
synonym: "galacturonate anabolism" EXACT []
synonym: "galacturonate biosynthesis" EXACT []
synonym: "galacturonate formation" EXACT []
synonym: "galacturonate synthesis" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0033482
name: D-galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:jsg, GOC:mah]
synonym: "D-galacturonate anabolism" EXACT []
synonym: "D-galacturonate biosynthesis" EXACT []
synonym: "D-galacturonate formation" EXACT []
synonym: "D-galacturonate synthesis" EXACT []
is_a: GO:0033481 ! galacturonate biosynthetic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0046396 ! D-galacturonate metabolic process

[Term]
id: GO:0033483
name: obsolete gas homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0033484
name: intracellular nitric oxide homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of nitric oxide within a cell." [GOC:mah]
synonym: "cellular nitric oxide homeostasis" EXACT []
synonym: "nitric oxide homeostasis" BROAD []
synonym: "NO homeostasis" BROAD []
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0033485
name: cyanidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125]
synonym: "cyanidin 3-O-glucoside anabolism" EXACT []
synonym: "cyanidin 3-O-glucoside biosynthesis" EXACT []
synonym: "cyanidin 3-O-glucoside formation" EXACT []
synonym: "cyanidin 3-O-glucoside synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:1901038 ! cyanidin 3-O-glucoside metabolic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0033486
name: delphinidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5153]
synonym: "delphinidin 3-O-glucoside anabolism" EXACT []
synonym: "delphinidin 3-O-glucoside biosynthesis" EXACT []
synonym: "delphinidin 3-O-glucoside formation" EXACT []
synonym: "delphinidin 3-O-glucoside synthesis" EXACT []
xref: MetaCyc:PWY-5153
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0033487
name: pelargonidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125]
synonym: "pelargonidin 3-O-glucoside anabolism" EXACT []
synonym: "pelargonidin 3-O-glucoside biosynthesis" EXACT []
synonym: "pelargonidin 3-O-glucoside formation" EXACT []
synonym: "pelargonidin 3-O-glucoside synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0033488
name: cholesterol biosynthetic process via 24,25-dihydrolanosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol." [GOC:mah, MetaCyc:PWY66-3]
synonym: "cholesterol anabolism via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol biosynthesis via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol formation via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol synthesis via 24,25-dihydrolanosterol" EXACT []
xref: MetaCyc:PWY66-3
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033489
name: cholesterol biosynthetic process via desmosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol." [GOC:mah, MetaCyc:PWY66-4]
synonym: "cholesterol anabolism via desmosterol" EXACT []
synonym: "cholesterol biosynthesis via desmosterol" EXACT []
synonym: "cholesterol formation via desmosterol" EXACT []
synonym: "cholesterol synthesis via desmosterol" EXACT []
xref: MetaCyc:PWY66-4
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033490
name: cholesterol biosynthetic process via lathosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341]
synonym: "cholesterol anabolism via lathosterol" EXACT []
synonym: "cholesterol biosynthesis via lathosterol" EXACT []
synonym: "cholesterol formation via lathosterol" EXACT []
synonym: "cholesterol synthesis via lathosterol" EXACT []
xref: MetaCyc:PWY66-341
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033491
name: coniferin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside." [GOC:mah, MetaCyc:PWY-116]
synonym: "coniferin metabolism" EXACT []
xref: MetaCyc:PWY-116
is_a: GO:0018904 ! ether metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:0033492
name: esculetin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin." [GOC:mah]
synonym: "esculetin metabolism" EXACT []
is_a: GO:0009804 ! coumarin metabolic process

[Term]
id: GO:0033493
name: esculetin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin." [GOC:mah]
synonym: "esculetin anabolism" EXACT []
synonym: "esculetin biosynthesis" EXACT []
synonym: "esculetin formation" EXACT []
synonym: "esculetin synthesis" EXACT []
xref: MetaCyc:PWY-5349
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:0033492 ! esculetin metabolic process

[Term]
id: GO:0033494
name: ferulate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah]
synonym: "ferulate metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0033495
name: ferulate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah]
synonym: "ferulate anabolism" EXACT []
synonym: "ferulate biosynthesis" EXACT []
synonym: "ferulate formation" EXACT []
synonym: "ferulate synthesis" EXACT []
is_a: GO:0033494 ! ferulate metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0033496
name: sinapate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah]
synonym: "sinapate metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0033497
name: sinapate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah]
synonym: "sinapate anabolism" EXACT []
synonym: "sinapate biosynthesis" EXACT []
synonym: "sinapate formation" EXACT []
synonym: "sinapate synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033496 ! sinapate metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0033498
name: galactose catabolic process via D-galactonate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate." [GOC:mah, MetaCyc:GALDEG-PWY]
synonym: "galactose breakdown via D-galactonate" EXACT []
synonym: "galactose catabolism via D-galactonate" EXACT []
synonym: "galactose degradation via D-galactonate" EXACT []
xref: MetaCyc:GALDEG-PWY
is_a: GO:0019388 ! galactose catabolic process

[Term]
id: GO:0033499
name: galactose catabolic process via UDP-galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah]
synonym: "galactose breakdown via UDP-galactose" EXACT []
synonym: "galactose catabolism via UDP-galactose" EXACT []
synonym: "galactose degradation via UDP-galactose" EXACT []
synonym: "Leloir Pathway" RELATED [PMID:14741191]
xref: MetaCyc:PWY-6317
is_a: GO:0019388 ! galactose catabolic process

[Term]
id: GO:0033500
name: carbohydrate homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0033501
name: obsolete galactose homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell." [GOC:mah]
comment: This term was obsoleted because it does not specify whether it represent an intracellular or an organism-level process.
is_obsolete: true
consider: GO:0140425

[Term]
id: GO:0033502
name: obsolete intracellular galactose homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of galactose within a cell." [GOC:dph, GOC:mah, GOC:tb, PMID:21621292]
comment: This term was obsoleted because there is no evidence that this process exist.
synonym: "cell galactose homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "cellular galactose homeostasis" EXACT []
is_obsolete: true
consider: GO:0140425

[Term]
id: GO:0033503
name: HULC complex
namespace: cellular_component
def: "A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0033504
name: floor plate development
namespace: biological_process
def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0033505
name: floor plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0033504 ! floor plate development

[Term]
id: GO:0033506
name: glucosinolate biosynthetic process from homomethionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine." [GOC:mah, MetaCyc:PWY-1187]
synonym: "glucosinolate anabolism from homomethionine" EXACT []
synonym: "glucosinolate biosynthesis from homomethionine" EXACT []
synonym: "glucosinolate formation from homomethionine" EXACT []
synonym: "glucosinolate synthesis from homomethionine" EXACT []
xref: MetaCyc:PWY-1187
is_a: GO:0019761 ! glucosinolate biosynthetic process
is_a: GO:0033321 ! homomethionine metabolic process

[Term]
id: GO:0033507
name: glucosinolate biosynthetic process from phenylalanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine." [GOC:mah, MetaCyc:PWY-2821]
synonym: "glucosinolate anabolism from phenylalanine" EXACT []
synonym: "glucosinolate biosynthesis from phenylalanine" EXACT []
synonym: "glucosinolate formation from phenylalanine" EXACT []
synonym: "glucosinolate synthesis from phenylalanine" EXACT []
xref: MetaCyc:PWY-2821
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0033508
name: glutamate catabolic process to butyrate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate." [GOC:mah, MetaCyc:PWY-5087]
synonym: "glutamate breakdown to butyrate" EXACT []
synonym: "glutamate degradation to butyrate" EXACT []
xref: MetaCyc:PWY-5087
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019605 ! butyrate metabolic process

[Term]
id: GO:0033509
name: glutamate catabolic process to propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate." [GOC:mah, MetaCyc:PWY-5088]
synonym: "glutamate breakdown to propionate" EXACT []
synonym: "glutamate degradation to propionate" EXACT []
xref: MetaCyc:PWY-5088
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0033510
name: luteolin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah]
synonym: "luteolin metabolism" EXACT []
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0033511
name: luteolin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah]
synonym: "luteolin anabolism" EXACT []
synonym: "luteolin biosynthesis" EXACT []
synonym: "luteolin formation" EXACT []
synonym: "luteolin synthesis" EXACT []
xref: MetaCyc:PWY-5060
is_a: GO:0033510 ! luteolin metabolic process
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0033512
name: L-lysine catabolic process to acetyl-CoA via saccharopine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine." [GOC:mah, MetaCyc:LYSINE-DEG1-PWY]
synonym: "L-lysine breakdown to acetyl-CoA via saccharopine" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via saccharopine" EXACT []
xref: MetaCyc:LYSINE-DEG1-PWY
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033513
name: L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide." [GOC:mah, MetaCyc:PWY-5280]
synonym: "L-lysine breakdown to acetyl-CoA via 5-aminopentanamide" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via 5-aminopentanamide" EXACT []
xref: MetaCyc:PWY-5280
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033514
name: L-lysine catabolic process to acetyl-CoA via L-pipecolate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate." [GOC:mah, MetaCyc:PWY-5283]
synonym: "L-lysine breakdown to acetyl-CoA via L-pipecolate" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via L-pipecolate" EXACT []
xref: MetaCyc:PWY-5283
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033515
name: L-lysine catabolic process using lysine 6-aminotransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase." [GOC:mah, MetaCyc:PWY-5298]
synonym: "L-lysine breakdown using lysine 6-aminotransferase" EXACT [GOC:mah]
synonym: "L-lysine degradation using lysine 6-aminotransferase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5298
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033516
name: L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine." [GOC:mah, MetaCyc:PWY-702]
synonym: "L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:PWY-702
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0033517
name: myo-inositol hexakisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [PMID:16107538]
synonym: "myo-inositol hexakisphosphate metabolism" EXACT []
synonym: "phytate metabolic process" EXACT []
synonym: "phytate metabolism" EXACT []
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0033518
name: obsolete myo-inositol hexakisphosphate dephosphorylation
namespace: biological_process
def: "OBSOLETE. The process of removing one or more phosphate group from myo-inositol hexakisphosphate." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "phytate dephosphorylation" EXACT []
is_obsolete: true

[Term]
id: GO:0033519
name: phytyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [GOC:mah]
synonym: "phytyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0033520
name: phytol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah]
synonym: "phytol anabolism" EXACT []
synonym: "phytol biosynthesis" EXACT []
synonym: "phytol formation" EXACT []
synonym: "phytol synthesis" EXACT []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0033306 ! phytol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1903175 ! fatty alcohol biosynthetic process

[Term]
id: GO:0033521
name: phytyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [GOC:mah]
synonym: "phytyl diphosphate anabolism" EXACT []
synonym: "phytyl diphosphate biosynthesis" EXACT []
synonym: "phytyl diphosphate formation" EXACT []
synonym: "phytyl diphosphate synthesis" EXACT []
xref: MetaCyc:PWY-5063
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033519 ! phytyl diphosphate metabolic process

[Term]
id: GO:0033522
name: obsolete histone H2A ubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by addition of one or more ubiquitin groups." [GOC:bf, GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0033523
name: obsolete histone H2B ubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H2B by addition of ubiquitin groups." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0033524
name: sinapate ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah]
synonym: "sinapate ester metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0033525
name: sinapate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah]
synonym: "sinapate ester anabolism" EXACT []
synonym: "sinapate ester biosynthesis" EXACT []
synonym: "sinapate ester formation" EXACT []
synonym: "sinapate ester synthesis" EXACT []
xref: MetaCyc:PWY-3301
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033524 ! sinapate ester metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0033526
name: tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [GOC:mah, MetaCyc:PWY-5188]
synonym: "tetrapyrrole anabolism from glutamate" EXACT []
synonym: "tetrapyrrole biosynthesis from glutamate" EXACT []
synonym: "tetrapyrrole formation from glutamate" EXACT []
synonym: "tetrapyrrole synthesis from glutamate" EXACT []
xref: MetaCyc:PWY-5188
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:0033527
name: tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA." [GOC:mah, MetaCyc:PWY-5189]
synonym: "tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole formation from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT []
xref: MetaCyc:PWY-5189
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:0033528
name: S-methylmethionine cycle
namespace: biological_process
def: "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441]
xref: MetaCyc:PWY-5441
is_a: GO:0033477 ! S-methylmethionine metabolic process

[Term]
id: GO:0033529
name: raffinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "raffinose anabolism" EXACT []
synonym: "raffinose biosynthesis" EXACT []
synonym: "raffinose formation" EXACT []
synonym: "raffinose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0033530
name: raffinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "raffinose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033531
name: stachyose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "stachyose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033532
name: stachyose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "stachyose anabolism" EXACT []
synonym: "stachyose biosynthesis" EXACT []
synonym: "stachyose formation" EXACT []
synonym: "stachyose synthesis" EXACT []
xref: MetaCyc:PWY-5337
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033531 ! stachyose metabolic process

[Term]
id: GO:0033533
name: verbascose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "verbascose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033534
name: verbascose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "verbascose anabolism" EXACT []
synonym: "verbascose biosynthesis" EXACT []
synonym: "verbascose formation" EXACT []
synonym: "verbascose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033533 ! verbascose metabolic process

[Term]
id: GO:0033535
name: ajugose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "ajugose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033536
name: ajugose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "ajugose anabolism" EXACT []
synonym: "ajugose biosynthesis" EXACT []
synonym: "ajugose formation" EXACT []
synonym: "ajugose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033535 ! ajugose metabolic process

[Term]
id: GO:0033537
name: ajugose biosynthetic process using galactinol:raffinose galactosyltransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide." [GOC:mah, MetaCyc:PWY-5342]
synonym: "ajugose anabolism using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose biosynthesis using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose formation using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose synthesis using galactinol:raffinose galactosyltransferase" EXACT []
xref: MetaCyc:PWY-5342
is_a: GO:0033536 ! ajugose biosynthetic process

[Term]
id: GO:0033538
name: ajugose biosynthetic process using galactan:galactan galactosyltransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another." [GOC:mah, MetaCyc:PWY-5343]
synonym: "ajugose anabolism using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose biosynthesis using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose formation using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose synthesis using galactan:galactan galactosyltransferase" EXACT []
xref: MetaCyc:PWY-5343
is_a: GO:0033536 ! ajugose biosynthetic process

[Term]
id: GO:0033539
name: fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY]
xref: MetaCyc:FAO-PWY
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033540
name: fatty acid beta-oxidation using acyl-CoA oxidase
namespace: biological_process
def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]
xref: MetaCyc:PWY-5136
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033541
name: fatty acid beta-oxidation, unsaturated, odd number
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5137]
xref: MetaCyc:PWY-5137
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033542
name: fatty acid beta-oxidation, unsaturated, even number
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
xref: MetaCyc:PWY-5138
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033543
name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number

[Term]
id: GO:0033544
name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number

[Term]
id: GO:0033545
name: myo-inositol hexakisphosphate biosynthetic process, lipid-dependent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C." [GOC:mah, MetaCyc:PWY-6555]
synonym: "myo-inositol hexakisphosphate anabolism, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate formation, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, lipid-dependent" EXACT []
synonym: "phytate biosynthesis, lipid-dependent" EXACT []
synonym: "phytate biosynthetic process, lipid-dependent" EXACT []
xref: MetaCyc:PWY-6555
is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process

[Term]
id: GO:0033546
name: myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further." [GOC:mah, MetaCyc:PWY-6554]
synonym: "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "phytate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "phytate biosynthetic process, via inositol 1,3,4-trisphosphate" EXACT []
xref: MetaCyc:PWY-6554
is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent

[Term]
id: GO:0033547
name: obsolete myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 1D myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate." [GOC:mah, MetaCyc:PWY-4541]
comment: This term was made obsolete because its only cross-reference points to a MetaCyc entry (PWY-4541) that was deleted from the MetaCyc database.
synonym: "myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
is_obsolete: true

[Term]
id: GO:0033548
name: myo-inositol hexakisphosphate biosynthetic process, lipid-independent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate." [GOC:mah, MetaCyc:PWY-4661]
synonym: "myo-inositol hexakisphosphate anabolism, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate formation, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, lipid-independent" EXACT []
synonym: "phytate biosynthesis, lipid-independent" EXACT []
synonym: "phytate biosynthetic process, lipid-independent" EXACT []
xref: MetaCyc:PWY-4661
is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process

[Term]
id: GO:0033549
name: MAP kinase phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]
synonym: "MAPK phosphatase activity" EXACT [PMID:12184814]
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0033550
name: MAP kinase tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah]
synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT []
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity

[Term]
id: GO:0033551
name: monopolin complex
namespace: cellular_component
def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824]
synonym: "monopolin subcomplex Csm1/Lrs4" NARROW []
synonym: "Pcs1/Mde4 complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0033552
name: response to vitamin B3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:sl]
synonym: "response to niacin" NARROW []
synonym: "response to nicotinamide" NARROW []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033553
name: rDNA heterochromatin
namespace: cellular_component
alt_id: GO:1902377
def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah, PMID:20661445]
synonym: "nuclear rDNA heterochromatin" NARROW []
synonym: "ribosomal DNA heterochromatin" EXACT []
synonym: "ribosomal DNA heterochromatin of cell nucleus" NARROW [GOC:TermGenie]
synonym: "ribosomal DNA heterochromatin of nucleus" NARROW [GOC:TermGenie]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0033554
name: cellular response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
is_a: GO:0006950 ! response to stress
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0033555
name: multicellular organismal response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
is_a: GO:0006950 ! response to stress
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0033556
name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995]
synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033557
name: Slx1-Slx4 complex
namespace: cellular_component
def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0033558
name: protein lysine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: Removal of an acetyl group from a lysine residue in a protein." [PMID:27296530, RHEA:58108]
synonym: "protein deacetylase activity" EXACT []
xref: Reactome:R-HSA-5693092 "Unknown deacetylase deacetylates 7K-BACE1(46-501)"
xref: Reactome:R-HSA-8952069 "HDAC4 deacetylates RUNX3"
xref: Reactome:R-HSA-9626962 "SIRT1 deacetylates FOXO1"
xref: Reactome:R-HSA-9701565 "HDACs deacetylate p-STAT3 dimers"
xref: Reactome:R-HSA-9825772 "SIRT1 deacetylates HINT1 dimer"
xref: Reactome:R-HSA-9841847 "SIRT3 deacetylates Ac-K272,K290-FOXO3"
xref: RHEA:58108
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0033559
name: unsaturated fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah]
synonym: "unsaturated fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0033560
name: folate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pde]
xref: Reactome:R-HSA-197963 "DHFR2 reduces FOLA to DHF"
xref: Reactome:R-HSA-197972 "DHF is reduced to tetrahydrofolate (THF)"
xref: Reactome:R-HSA-9709098 "DHFR dimer reduces FOLA to DHF"
xref: RHEA:31103
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033561
name: obsolete regulation of water loss via skin
namespace: biological_process
def: "OBSOLETE. A process that modulates the rate or extent of water loss from an organism via the skin." [GOC:mah]
comment: This term was obsoleted because it represents a readout.
synonym: "skin barrier function" RELATED []
is_obsolete: true
consider: GO:0043589
consider: GO:0098773

[Term]
id: GO:0033562
name: co-transcriptional gene silencing by RNA interference machinery
namespace: biological_process
def: "A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin." [GOC:mah, GOC:vw, PMID:17512405, PMID:21151114, PMID:22431512]
synonym: "co-transcriptional gene silencing by small RNA" EXACT [GOC:vw]
synonym: "cotranscriptional gene silencing by RNA interference machinery" RELATED []
synonym: "cotranscriptional gene silencing by small RNA" RELATED []
synonym: "RNAi-mediated CTGS" EXACT [GOC:vw]
synonym: "small RNA-mediated cotranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031047 ! regulatory ncRNA-mediated gene silencing

[Term]
id: GO:0033563
name: dorsal/ventral axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb]
synonym: "dorsal-ventral axon guidance" EXACT [GOC:mah]
synonym: "dorsal/ventral axon pathfinding" EXACT [GOC:mah]
synonym: "dorsoventral axon guidance" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0033564
name: anterior/posterior axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:kmv, GOC:tb]
synonym: "anterior-posterior axon guidance" EXACT []
synonym: "anterior/posterior axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0033565
name: ESCRT-0 complex
namespace: cellular_component
def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868]
synonym: "Hrs/STAM complex" EXACT []
synonym: "Vps27p-Hse1p complex" EXACT []
is_a: GO:0036452 ! ESCRT complex

[Term]
id: GO:0033566
name: gamma-tubulin complex localization
namespace: biological_process
def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT []
synonym: "gamma-tubulin complex localisation" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0033567
name: DNA replication, Okazaki fragment processing
namespace: biological_process
def: "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006273 ! lagging strand elongation

[Term]
id: GO:0033568
name: lactoferrin receptor activity
namespace: molecular_function
def: "Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH." [GOC:bf, GOC:mlg, PMID:16261254]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0033569
name: lactoferrin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg]
is_a: GO:0008320 ! protein transmembrane transporter activity

[Term]
id: GO:0033570
name: obsolete transferrin transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of transferrin from one side of a membrane to the other." [GOC:mlg]
comment: This term was obsoleted because there is no evidence that this function exists.
is_obsolete: true

[Term]
id: GO:0033571
name: lactoferrin transport
namespace: biological_process
def: "The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
is_a: GO:0006826 ! iron ion transport
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0033572
name: transferrin transport
namespace: biological_process
def: "The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
synonym: "melanotransferrin transport" EXACT [PR:000001887]
is_a: GO:0006826 ! iron ion transport
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0033573
name: high-affinity iron permease complex
namespace: cellular_component
def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jp, PMID:16522632, PMID:8599111]
synonym: "high affinity iron permease complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902495 ! transmembrane transporter complex
is_a: GO:1905862 ! ferroxidase complex

[Term]
id: GO:0033574
name: response to testosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl]
synonym: "response to testosterone stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0033575
name: obsolete protein glycosylation at cell surface
namespace: biological_process
def: "OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid at the surface of a cell." [GOC:mah, GOC:pr, PMID:12042244]
comment: This term was obsoleted because it represented both a process and a cellular component.
synonym: "protein amino acid glycosylation at cell surface" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0006486

[Term]
id: GO:0033576
name: obsolete protein glycosylation in cytosol
namespace: biological_process
def: "OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol." [GOC:mah, GOC:pr, PMID:12042244]
comment: This term was obsoleted because it represented both a process and a cellular component.
synonym: "protein amino acid glycosylation in cytosol" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0006486

[Term]
id: GO:0033577
name: obsolete protein glycosylation in endoplasmic reticulum
namespace: biological_process
def: "OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, GOC:pr, PMID:12042244]
synonym: "core glycosylation" RELATED [PMID:6345657]
synonym: "protein amino acid glycosylation in endoplasmic reticulum" EXACT [GOC:bf]
synonym: "protein amino acid glycosylation in ER" EXACT []
is_obsolete: true
replaced_by: GO:0006486

[Term]
id: GO:0033578
name: obsolete protein glycosylation in Golgi
namespace: biological_process
def: "OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, GOC:pr, PMID:12042244]
synonym: "protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
synonym: "terminal glycosylation" NARROW [PMID:6345657]
is_obsolete: true
replaced_by: GO:0006486

[Term]
id: GO:0033579
name: obsolete protein galactosylation in endoplasmic reticulum
namespace: biological_process
def: "OBSOLETE. The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah]
synonym: "protein amino acid galactosylation in endoplasmic reticulum" EXACT [GOC:bf]
synonym: "protein amino acid galactosylation in ER" EXACT []
is_obsolete: true
replaced_by: GO:0042125

[Term]
id: GO:0033580
name: obsolete protein galactosylation at cell surface
namespace: biological_process
def: "OBSOLETE. The addition of a galactose unit to a protein amino acid at the surface of a cell." [GOC:mah]
comment: This term was obsoleted because it represented both a process and a cellular component.
synonym: "protein amino acid galactosylation at cell surface" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0042125

[Term]
id: GO:0033581
name: obsolete protein galactosylation in Golgi
namespace: biological_process
def: "OBSOLETE. The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah]
synonym: "protein amino acid galactosylation in Golgi" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0042125

[Term]
id: GO:0033582
name: obsolete protein galactosylation in cytosol
namespace: biological_process
def: "OBSOLETE. The addition of a galactose unit to a protein amino acid in the cytosol." [GOC:mah]
comment: This term was obsoleted because it represented both a process and a cellular component.
synonym: "protein amino acid galactosylation in cytosol" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0042125

[Term]
id: GO:0033583
name: rhabdomere membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0033584
name: L-tyrosine biosynthetic process from chorismate via L-arogenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-tyrosine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:mah]
synonym: "L-tyrosine anabolism from chorismate via L-arogenate" EXACT []
synonym: "L-tyrosine formation from chorismate via L-arogenate" EXACT []
synonym: "L-tyrosine synthesis from chorismate via L-arogenate" EXACT []
synonym: "tyrosine biosynthetic process from chorismate via L-arogenate" BROAD []
xref: MetaCyc:PWY-3461
is_a: GO:0006571 ! tyrosine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0033585
name: L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate." [GOC:go_curators]
synonym: "L-phenylalanine anabolism from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine biosynthesis from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine formation from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine synthesis from chorismate via phenylpyruvate" EXACT []
xref: MetaCyc:PHESYN
is_a: GO:0009094 ! L-phenylalanine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0033586
name: L-phenylalanine biosynthetic process from chorismate via L-arogenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:go_curators]
synonym: "L-phenylalanine anabolism from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine biosynthesis from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine formation from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine synthesis from chorismate via L-arogenate" EXACT []
xref: MetaCyc:PWY-3462
is_a: GO:0009094 ! L-phenylalanine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0033588
name: elongator holoenzyme complex
namespace: cellular_component
alt_id: GO:0033589
def: "A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]
comment: Despite its name, this complex is not directly involved in transcriptional elongation (PMID:23165209).
synonym: "Elongator core complex" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0033590
name: response to cobalamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:sl]
synonym: "response to vitamin B12" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033591
name: response to L-ascorbic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:sl]
synonym: "response to ascorbic acid" BROAD []
synonym: "response to L-ascorbate" EXACT []
synonym: "response to vitamin C" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:0034284 ! response to monosaccharide

[Term]
id: GO:0033592
name: RNA strand annealing activity
namespace: molecular_function
def: "An activity that facilitates the formation of a complementary double-stranded RNA molecule." [GOC:mah, PMID:7543843]
is_a: GO:0003727 ! single-stranded RNA binding
is_a: GO:0140666 ! annealing activity

[Term]
id: GO:0033593
name: BRCA2-MAGE-D1 complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0033594
name: response to hydroxyisoflavone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah]
is_a: GO:0080184 ! response to phenylpropanoid
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0033595
name: response to genistein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah]
is_a: GO:0033594 ! response to hydroxyisoflavone

[Term]
id: GO:0033596
name: TSC1-TSC2 complex
namespace: cellular_component
def: "A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671]
synonym: "tuberin-hamartin complex" EXACT []
synonym: "tuberous sclerosis complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0033597
name: mitotic checkpoint complex
namespace: cellular_component
def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307]
synonym: "MCC" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0033598
name: mammary gland epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0061180 ! mammary gland epithelium development

[Term]
id: GO:0033599
name: regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033600
name: negative regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
synonym: "down regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "down-regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "downregulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "inhibition of mammary gland epithelial cell proliferation" NARROW []
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033601
name: positive regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
synonym: "activation of mammary gland epithelial cell proliferation" NARROW []
synonym: "stimulation of mammary gland epithelial cell proliferation" NARROW []
synonym: "up regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "up-regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "upregulation of mammary gland epithelial cell proliferation" EXACT []
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033602
name: negative regulation of dopamine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "down regulation of dopamine secretion" EXACT []
synonym: "down-regulation of dopamine secretion" EXACT []
synonym: "downregulation of dopamine secretion" EXACT []
synonym: "inhibition of dopamine secretion" NARROW []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
relationship: negatively_regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0033603
name: positive regulation of dopamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "activation of dopamine secretion" NARROW []
synonym: "stimulation of dopamine secretion" NARROW []
synonym: "up regulation of dopamine secretion" EXACT []
synonym: "up-regulation of dopamine secretion" EXACT []
synonym: "upregulation of dopamine secretion" EXACT []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
relationship: positively_regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0033604
name: negative regulation of catecholamine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "down regulation of catecholamine secretion" EXACT []
synonym: "down-regulation of catecholamine secretion" EXACT []
synonym: "downregulation of catecholamine secretion" EXACT []
synonym: "inhibition of catecholamine secretion" NARROW []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033605
name: positive regulation of catecholamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "activation of catecholamine secretion" NARROW []
synonym: "stimulation of catecholamine secretion" NARROW []
synonym: "up regulation of catecholamine secretion" EXACT []
synonym: "up-regulation of catecholamine secretion" EXACT []
synonym: "upregulation of catecholamine secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033606
name: chemokine receptor transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a chemokine receptor within a lipid bilayer." [GOC:mah]
synonym: "chemokine receptor translocation within membrane" EXACT []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0033607
name: SOD1-Bcl-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0033608
name: formyl-CoA transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, RHEA:16545]
synonym: "formyl-CoA oxalate CoA-transferase activity" RELATED [EC:2.8.3.16]
synonym: "formyl-CoA:oxalate CoA-transferase activity" RELATED [EC:2.8.3.16]
synonym: "formyl-coenzyme A transferase activity" RELATED [EC:2.8.3.16]
xref: EC:2.8.3.16
xref: KEGG_REACTION:R07290
xref: MetaCyc:RXN0-1382
xref: RHEA:16545
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0033609
name: oxalate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate." [GOC:mlg]
synonym: "ethanedioate metabolic process" EXACT []
synonym: "ethanedioic acid metabolic process" EXACT []
synonym: "oxalate metabolism" EXACT []
synonym: "oxalic acid metabolic process" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0033610
name: oxalate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate." [GOC:mlg]
synonym: "ethanedioate biosynthetic process" EXACT []
synonym: "ethanedioic acid biosynthetic process" EXACT []
synonym: "oxalate anabolism" EXACT []
synonym: "oxalate biosynthesis" EXACT []
synonym: "oxalate formation" EXACT []
synonym: "oxalate synthesis" EXACT []
synonym: "oxalic acid biosynthetic process" EXACT []
is_a: GO:0033609 ! oxalate metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0033611
name: oxalate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate." [GOC:mlg]
synonym: "ethanedioate catabolic process" EXACT []
synonym: "ethanedioic acid catabolic process" EXACT []
synonym: "oxalate breakdown" EXACT []
synonym: "oxalate catabolism" EXACT []
synonym: "oxalate degradation" EXACT []
synonym: "oxalic acid catabolic process" EXACT []
is_a: GO:0033609 ! oxalate metabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0033612
name: receptor serine/threonine kinase binding
namespace: molecular_function
def: "Binding to a receptor that possesses protein serine/threonine kinase activity." [GOC:mah]
synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0033614
name: chloroplast proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
relationship: part_of GO:0009658 ! chloroplast organization

[Term]
id: GO:0033615
name: mitochondrial proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah]
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly

[Term]
id: GO:0033616
name: plasma membrane proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0033617
name: mitochondrial cytochrome c oxidase assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]
synonym: "mitochondrial cytochrome c oxidase biogenesis" BROAD []
synonym: "mitochondrial cytochrome c oxidase complex assembly" EXACT []
synonym: "mitochondrial respiratory chain complex IV assembly" EXACT []
is_a: GO:0008535 ! respiratory chain complex IV assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly

[Term]
id: GO:0033618
name: plasma membrane respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane." [GOC:mah]
synonym: "plasma membrane cytochrome c oxidase biogenesis" BROAD []
synonym: "plasma membrane cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0008535 ! respiratory chain complex IV assembly
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0033619
name: membrane protein proteolysis
namespace: biological_process
def: "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pde]
is_a: GO:0006508 ! proteolysis

[Term]
id: GO:0033620
name: Mei2 nuclear dot complex
namespace: cellular_component
def: "A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [GOC:vw, PMID:12808043]
synonym: "Mei2 dot" EXACT []
synonym: "Mei2 nuclear dot" BROAD []
synonym: "nuclear body" RELATED []
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0033621
name: nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
namespace: biological_process
def: "The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [PMID:16823445]
comment: Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing.
synonym: "degradation of meiosis-specific transcripts" EXACT []
synonym: "mRNA breakdown, meiosis-specific transcripts" EXACT []
synonym: "mRNA catabolism, meiosis-specific transcripts" EXACT []
synonym: "mRNA degradation, meiosis-specific transcripts" EXACT []
synonym: "nuclear mRNA catabolic process, meiosis-specific transcripts" EXACT []
is_a: GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0033622
name: integrin activation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "integrin complex activation" EXACT []
synonym: "integrin complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0033623
name: regulation of integrin activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "regulation of integrin complex activation" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033624
name: negative regulation of integrin activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "negative regulation of integrin complex activation" EXACT []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0033623 ! regulation of integrin activation
relationship: negatively_regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033625
name: positive regulation of integrin activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "positive regulation of integrin complex activation" EXACT []
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0033623 ! regulation of integrin activation
relationship: positively_regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033626
name: positive regulation of integrin activation by cell surface receptor linked signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of integrin activation by cell surface receptor linked signal transduction. This can occur by increased affinity of an integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell surface receptor linked signal transduction leading to integrin activation" EXACT [GOC:bf, GOC:signaling]
synonym: "cell surface receptor linked signal transduction leading to integrin complex activation" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0033625 ! positive regulation of integrin activation

[Term]
id: GO:0033627
name: cell adhesion mediated by integrin
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0033628
name: regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033629
name: negative regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "negative regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
relationship: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033630
name: positive regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "positive regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
is_a: GO:0045785 ! positive regulation of cell adhesion
relationship: positively_regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033631
name: cell-cell adhesion mediated by integrin
namespace: biological_process
def: "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0033627 ! cell adhesion mediated by integrin
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0033632
name: regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
relationship: regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033633
name: negative regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "negative regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin
is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin
relationship: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033634
name: positive regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "positive regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin
is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin
relationship: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033635
name: symbiont-mediated perturbation of host response to abiotic stimulus
namespace: biological_process
def: "A process in which a symbiont alters or subverts the response of its host to an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modulation by symbiont of host response to abiotic stimulus" EXACT []
is_a: GO:0044003 ! symbiont-mediated perturbation of host process

[Term]
id: GO:0033636
name: obsolete modulation by symbiont of host response to temperature stimulus
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation by symbiont of host response to thermal stimulus" EXACT []
is_obsolete: true

[Term]
id: GO:0033637
name: obsolete modulation by symbiont of host response to cold
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "freezing tolerance" RELATED []
is_obsolete: true

[Term]
id: GO:0033638
name: symbiont-mediated perturbation of host heat acclimation
namespace: biological_process
def: "A process in which a symbiont alters or subverts the response of its host to heat acclimation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:17425405, PMID:35350854]
synonym: "modulation by symbiont of host heat acclimation" EXACT []
synonym: "modulation by symbiont of host response to heat" RELATED []
synonym: "response to heat shock" RELATED []
is_a: GO:0033635 ! symbiont-mediated perturbation of host response to abiotic stimulus

[Term]
id: GO:0033639
name: obsolete modulation by symbiont of host response to water
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0033640
name: obsolete modulation by symbiont of host response to osmotic stress
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0033641
name: obsolete modulation by symbiont of host response to pH
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0033642
name: obsolete modulation by symbiont of host response to gravitational stimulus
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "response to gravitational stimulus" BROAD []
is_obsolete: true

[Term]
id: GO:0033643
name: host cell part
namespace: cellular_component
def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0018995 ! host cellular component

[Term]
id: GO:0033644
name: host cell membrane
namespace: cellular_component
def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0033645
name: host cell endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0033646
name: host intracellular part
namespace: cellular_component
def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "host cell intracellular part" EXACT []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043656 ! host intracellular region

[Term]
id: GO:0033647
name: host intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0033648
name: host intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "host intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0033647 ! host intracellular organelle

[Term]
id: GO:0033650
name: host cell mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "host mitochondria" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0033651
name: host cell plastid
namespace: cellular_component
def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033648 ! host intracellular membrane-bounded organelle

[Term]
id: GO:0033652
name: host cell chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033651 ! host cell plastid

[Term]
id: GO:0033653
name: host cell chloroplast part
namespace: cellular_component
def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "host chloroplast component" EXACT []
is_a: GO:0033652 ! host cell chloroplast

[Term]
id: GO:0033654
name: host cell chloroplast thylakoid membrane
namespace: cellular_component
def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033653 ! host cell chloroplast part
is_a: GO:0044160 ! host thylakoid membrane

[Term]
id: GO:0033655
name: host cell cytoplasm part
namespace: cellular_component
def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cytoplasm component" BROAD []
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0030430 ! host cell cytoplasm

[Term]
id: GO:0033656
name: symbiont-mediated disruption of host chloroplast
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "disruption by symbiont of host chloroplast" EXACT []
synonym: "modification by symbiont of host chloroplast" RELATED []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0033657
name: obsolete disruption by symbiont of host chloroplast part
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "modification by symbiont of host chloroplast part" RELATED []
is_obsolete: true

[Term]
id: GO:0033658
name: symbiont-mediated disruption of host chloroplast thylakoid
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "disruption by symbiont of host chloroplast thylakoid" EXACT []
synonym: "modification by symbiont of host chloroplast thylakoid" RELATED []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0033659
name: symbiont-mediated disruption of host mitochondrion
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:35069483, PMID:37175745]
synonym: "disruption by symbiont of host mitochondrion" EXACT []
synonym: "modification by symbiont of host mitochondrion" RELATED []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0033660
name: symbiont-mediated suppression of host resistance gene-dependent defense response
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal execution of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "down regulation by symbiont of defense response in host by specific elicitors" EXACT []
synonym: "down-regulation by symbiont of host gene-for-gene resistance" EXACT []
synonym: "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
synonym: "inhibition by symbiont of host resistance gene-dependent defense response" NARROW []
synonym: "negative regulation by symbiont of host resistance gene-dependent defense response" EXACT []
synonym: "suppression by symbiont of host resistance gene-dependent defense response" EXACT []
is_a: GO:0044414 ! symbiont-mediated suppression of host defenses
is_a: GO:0052158 ! symbiont-mediated perturbation of host resistance gene-dependent defense response

[Term]
id: GO:0033661
name: effector-mediated defense to host-produced reactive oxygen species
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of reactive oxygen species produced by the host as part of its innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "down regulation by organism of defense-related host metabolic burst" EXACT []
synonym: "down-regulation by organism of defense-related host oxidative burst" EXACT []
synonym: "downregulation by organism of defense-related host AOS production" EXACT []
synonym: "negative regulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "negative regulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "negative regulation by organism of defense-related host respiratory burst" EXACT []
synonym: "negative regulation by organism of defense-related host ROI production" EXACT []
synonym: "negative regulation by organism of defense-related host ROS production" EXACT []
synonym: "negative regulation by symbiont of defense-related host reactive oxygen species production" EXACT []
synonym: "suppression by symbiont of defense-related host reactive oxygen species production" RELATED []
is_a: GO:0052164 ! symbiont defense to host-produced reactive oxygen species

[Term]
id: GO:0033662
name: obsolete modulation by symbiont of host defense-related protein level
namespace: biological_process
def: "OBSOLETE. The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
is_obsolete: true

[Term]
id: GO:0033663
name: obsolete negative regulation by symbiont of host defense-related protein level
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
is_obsolete: true

[Term]
id: GO:0033664
name: obsolete positive regulation by symbiont of host defense-related protein level
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
is_obsolete: true

[Term]
id: GO:0033665
name: obsolete regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:dph, GOC:pamgo_curators, GOC:tb]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "modulation of growth or development of organism within host" EXACT []
synonym: "modulation of growth or development of symbiont within host" EXACT [GOC:dph, GOC:tb]
synonym: "modulation of invasive growth" BROAD []
synonym: "regulation of growth or development of symbiont in host" EXACT []
synonym: "regulation of growth or development of symbiont within host" EXACT []
is_obsolete: true
consider: GO:0044127

[Term]
id: GO:0033666
name: obsolete positive regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "positive regulation of growth or development of symbiont in host" EXACT []
synonym: "positive regulation of growth or development of symbiont within host" EXACT []
synonym: "positive regulation of invasive growth" BROAD []
synonym: "up regulation of growth or development of organism within host" EXACT []
synonym: "up-regulation of growth or development of organism within host" EXACT []
synonym: "upregulation of growth or development of organism within host" EXACT []
is_obsolete: true
consider: GO:0044129

[Term]
id: GO:0033667
name: obsolete negative regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "down regulation of growth or development of organism within host" EXACT []
synonym: "down-regulation of growth or development of organism within host" EXACT []
synonym: "downregulation of growth or development of organism within host" EXACT []
synonym: "inhibition of growth of development of organism within host" NARROW []
synonym: "negative regulation of growth or development of symbiont in host" EXACT []
synonym: "negative regulation of growth or development of symbiont within host" EXACT []
synonym: "negative regulation of invasive growth" BROAD []
is_obsolete: true
consider: GO:0044131

[Term]
id: GO:0033668
name: symbiont-mediated suppression of host apoptosis
namespace: biological_process
alt_id: GO:0039650
def: "A process in which a symbiont inhibits or disrupts the normal execution of host apoptosis, leading to a decrease in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'.
synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "inhibition by organism of host apoptotic programmed cell death" EXACT []
synonym: "negative regulation by symbiont of host apoptosis" EXACT []
synonym: "negative regulation by symbiont of host apoptotic process" EXACT []
synonym: "negative regulation by virus of host apoptosis" NARROW []
synonym: "suppression by symbiont of host apoptotic process" EXACT []
synonym: "suppression by virus of host apoptosis" NARROW []
is_a: GO:0052041 ! symbiont-mediated suppression of host programmed cell death
is_a: GO:0052150 ! symbiont-mediated perturbation of host apoptosis

[Term]
id: GO:0033670
name: regulation of NAD+ kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "NAD kinase regulator" NARROW []
synonym: "regulation of NAD kinase activity" EXACT []
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:0033671
name: obsolete negative regulation of NAD+ kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of NAD+ kinase activity" EXACT []
synonym: "down-regulation of NAD+ kinase activity" EXACT []
synonym: "downregulation of NAD+ kinase activity" EXACT []
synonym: "inhibition of NAD+ kinase activity" NARROW []
synonym: "NAD+ kinase inhibitor" NARROW []
is_obsolete: true

[Term]
id: GO:0033672
name: obsolete positive regulation of NAD+ kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "NAD+ kinase activator" NARROW []
synonym: "stimulation of NAD+ kinase activity" NARROW []
synonym: "up regulation of NAD+ kinase activity" EXACT []
synonym: "up-regulation of NAD+ kinase activity" EXACT []
synonym: "upregulation of NAD+ kinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0033673
name: negative regulation of kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of kinase activity" EXACT []
synonym: "down-regulation of kinase activity" EXACT []
synonym: "downregulation of kinase activity" EXACT []
synonym: "inhibition of kinase activity" NARROW []
synonym: "kinase inhibitor" NARROW []
is_a: GO:0042326 ! negative regulation of phosphorylation
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051348 ! negative regulation of transferase activity

[Term]
id: GO:0033674
name: positive regulation of kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "kinase activator" NARROW []
synonym: "stimulation of kinase activity" NARROW []
synonym: "up regulation of kinase activity" EXACT []
synonym: "up-regulation of kinase activity" EXACT []
synonym: "upregulation of kinase activity" EXACT []
is_a: GO:0042327 ! positive regulation of phosphorylation
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051347 ! positive regulation of transferase activity

[Term]
id: GO:0033675
name: pericanalicular vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0033677
name: DNA/RNA helicase activity
namespace: molecular_function
alt_id: GO:0033680
def: "Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis." [GOC:mah]
synonym: "ATP-dependent DNA/RNA helicase activity" EXACT []
is_a: GO:0004386 ! helicase activity
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA
is_a: GO:0008186 ! ATP-dependent activity, acting on RNA
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0033678
name: 5'-3' DNA/RNA helicase activity
namespace: molecular_function
alt_id: GO:0033682
def: "Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis." [GOC:mah]
synonym: "5' to 3' DNA/RNA helicase activity" EXACT []
synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT []
synonym: "ATP-dependent 5'-3' DNA/RNA helicase activity" EXACT []
xref: Reactome:R-HSA-163120 "Disassociation of Telomerase RNP and the Chromosome End"
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033679
name: 3'-5' DNA/RNA helicase activity
namespace: molecular_function
alt_id: GO:0033681
def: "Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:mah]
synonym: "3' to 5' DNA/RNA helicase activity" EXACT []
synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT []
synonym: "ATP-dependent 3'-5' DNA/RNA helicase activity" EXACT []
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033683
name: obsolete nucleotide-excision repair, DNA incision
namespace: biological_process
def: "OBSOLETE. A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound." [GOC:elh, PMID:8631896]
comment: This term was obsoleted because it represents a molecular function.
synonym: "DNA incision involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb]
synonym: "nucleic acid cleavage involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0006289

[Term]
id: GO:0033684
name: regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
is_a: GO:0032276 ! regulation of gonadotropin secretion
relationship: regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033685
name: negative regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "down regulation of luteinizing hormone secretion" EXACT []
synonym: "down-regulation of luteinizing hormone secretion" EXACT []
synonym: "downregulation of luteinizing hormone secretion" EXACT []
synonym: "inhibition of luteinizing hormone secretion" NARROW []
is_a: GO:0032277 ! negative regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
relationship: negatively_regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033686
name: positive regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "activation of luteinizing hormone secretion" NARROW []
synonym: "stimulation of luteinizing hormone secretion" NARROW []
synonym: "up regulation of luteinizing hormone secretion" EXACT []
synonym: "up-regulation of luteinizing hormone secretion" EXACT []
synonym: "upregulation of luteinizing hormone secretion" EXACT []
is_a: GO:0032278 ! positive regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033687
name: osteoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0033688
name: regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033689
name: negative regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah]
synonym: "down regulation of osteoblast proliferation" EXACT []
synonym: "down-regulation of osteoblast proliferation" EXACT []
synonym: "downregulation of osteoblast proliferation" EXACT []
synonym: "inhibition of osteoblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0033688 ! regulation of osteoblast proliferation
relationship: negatively_regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033690
name: positive regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah]
synonym: "activation of osteoblast proliferation" NARROW []
synonym: "stimulation of osteoblast proliferation" NARROW []
synonym: "up regulation of osteoblast proliferation" EXACT []
synonym: "up-regulation of osteoblast proliferation" EXACT []
synonym: "upregulation of osteoblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0033688 ! regulation of osteoblast proliferation
relationship: positively_regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033691
name: sialic acid binding
namespace: molecular_function
def: "Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [GOC:add, ISBN:9780721601465]
synonym: "N-acetylneuraminic acid binding" NARROW []
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0033692
name: obsolete cellular polysaccharide biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell." [GOC:go_curators]
comment: This term was obsoleted because it is not different from its parent, polysaccharide biosynthetic process ; GO:0000271.
synonym: "cellular glycan biosynthesis" EXACT []
synonym: "cellular glycan biosynthetic process" EXACT []
synonym: "cellular polysaccharide anabolism" EXACT []
synonym: "cellular polysaccharide biosynthesis" EXACT []
synonym: "cellular polysaccharide formation" EXACT []
synonym: "cellular polysaccharide synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0000271

[Term]
id: GO:0033693
name: neurofilament bundle assembly
namespace: biological_process
def: "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules." [PMID:11034913, PMID:11264295]
synonym: "NF bundle assembly" EXACT []
is_a: GO:0045110 ! intermediate filament bundle assembly

[Term]
id: GO:0033694
name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
xref: EC:1.5.7.-
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0033695
name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5.-, GOC:mah]
xref: EC:1.17.5.-
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033696
name: heterochromatin boundary formation
namespace: biological_process
alt_id: GO:0031454
def: "A process that forms a boundary that limits the spreading of heterochromatin along a chromosome." [GOC:mah]
synonym: "maintenance of heterochromatin boundaries" RELATED []
synonym: "negative regulation of extent of heterochromatin assembly" RELATED []
synonym: "negative regulation of extent of heterochromatin formation" RELATED []
synonym: "negative regulation of heterochromatin spreading" RELATED []
synonym: "regulation of extent of heterochromatin assembly" RELATED []
synonym: "regulation of extent of heterochromatin formation" EXACT []
synonym: "regulation of heterochromatin spreading" RELATED []
is_a: GO:0070828 ! heterochromatin organization
relationship: part_of GO:0031507 ! heterochromatin formation

[Term]
id: GO:0033697
name: obsolete positive regulation of extent of heterochromatin assembly
namespace: biological_process
def: "OBSOLETE. Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah]
comment: This term has been obsoleted because there is no evidence it exists.
synonym: "positive regulation of extent of heterochromatin formation" EXACT []
synonym: "positive regulation of heterochromatin spreading" RELATED []
is_obsolete: true
consider: GO:0031507

[Term]
id: GO:0033698
name: Rpd3L complex
namespace: cellular_component
alt_id: GO:0000508
def: "A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a two copies of catalytic histone deacetylase subunit (S. pombe Clr6/ S. cerevisiae Rpd3p), an Sds-3 family protein (S. pombe /S. cerevisiae Sds3(p) ), two copies of SIN3 family co-repressor (S. pombe Pst1/ S. cerevisiae Sin3p, a WD repeat protein/ histone chaperone (S. pombe Prw1/ S. cerevisiae Ume1p), and a zf- PHD finger ( S. pombe Png2/ S. cerevisiae Pho23p), plus 4 additional subunits, and associated factors." [GOC:vw, PMID:17450151]
synonym: "Clr6 histone deacetylase complex I/I'" EXACT [GOC:rb, GOC:vw]
synonym: "Clr6L complex" EXACT [PMID:19040720]
synonym: "Rpd3C(L)" EXACT [PMID:32391601, PMID:34979096, PMID:37076472]
synonym: "Sin3L complex" EXACT []
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0033699
name: DNA 5'-adenosine monophosphate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982]
synonym: "AMP-removal activity" RELATED []
synonym: "DNA 5'-adenylate hydrolase activity" EXACT []
synonym: "DNA adenylate hydrolysis activity" BROAD []
synonym: "DNA de-adenylation" RELATED []
synonym: "DNA deadenylation" RELATED []
xref: EC:3.6.1.71
is_a: GO:0035312 ! 5'-3' DNA exonuclease activity

[Term]
id: GO:0033700
name: phospholipid efflux
namespace: biological_process
def: "The directed movement of a phospholipid out of a cell or organelle." [GOC:mah]
synonym: "phospholipid export" EXACT []
is_a: GO:0015914 ! phospholipid transport

[Term]
id: GO:0033701
name: dTDP-galactose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186]
synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" RELATED [EC:1.1.1.186]
synonym: "dTDPgalactose 6-dehydrogenase activity" RELATED [EC:1.1.1.186]
synonym: "thymidine-diphosphate-galactose dehydrogenase activity" RELATED [EC:1.1.1.186]
xref: EC:1.1.1.186
xref: MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN
xref: RHEA:12396
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033702
name: (+)-trans-carveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,5S)-carveol + NAD+ = (S)-carvone + H+ + NADH." [EC:1.1.1.275, RHEA:14825]
synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.275]
xref: EC:1.1.1.275
xref: KEGG_REACTION:R06117
xref: MetaCyc:RXN-9397
xref: RHEA:14825
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033703
name: 3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxy-5-beta-pregnane-20-one + NADP+ = 5-beta-pregnan-3,20-dione + H+ + NADPH." [RHEA:22944]
synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.277]
synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" RELATED [EC:1.1.1.277]
synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" RELATED [EC:1.1.1.277]
xref: EC:1.1.1.277
xref: KEGG_REACTION:R06166
xref: MetaCyc:1.1.1.277-RXN
xref: RHEA:22944
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033704
name: 3-beta-hydroxy-5-alpha-steroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: -3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5-alpha-pregnane-3,20-dione + H+ + NADPH." [RHEA:18137]
synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.278]
xref: EC:1.1.1.278
xref: KEGG_REACTION:R07138
xref: MetaCyc:1.1.1.278-RXN
xref: RHEA:18137
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033705
name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281]
comment: Note that this enzyme differs from EC:1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose).
synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281]
synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" RELATED [EC:1.1.1.281]
synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" RELATED [EC:1.1.1.281]
synonym: "Rmd" RELATED [EC:1.1.1.281]
xref: EC:1.1.1.281
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033706
name: obsolete quinate/shikimate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+, and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282]
comment: This term was made obsolete because it represents four reactions, and should be four separate terms.
synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" RELATED [EC:1.1.1.282]
synonym: "quinate/shikimate dehydrogenase activity" EXACT []
synonym: "YdiB" RELATED [EC:1.1.1.282]
is_obsolete: true
consider: GO:0004764
consider: GO:0030266
consider: GO:0052733
consider: GO:0052734

[Term]
id: GO:0033707
name: 3''-deamino-3''-oxonicotianamine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285]
synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" RELATED [EC:1.1.1.285]
xref: EC:1.1.1.285
xref: MetaCyc:1.1.1.285-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033708
name: isocitrate-homoisocitrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286]
synonym: "homoisocitrate-isocitrate dehydrogenase activity" RELATED [EC:1.1.1.286]
synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" RELATED [EC:1.1.1.286]
synonym: "PH1722" RELATED [EC:1.1.1.286]
xref: EC:1.1.1.286
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033709
name: D-arabinitol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+. Can also produce D-ribulose." [EC:1.1.1.287]
synonym: "ARD1p" RELATED [EC:1.1.1.287]
synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287]
synonym: "D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity" RELATED []
synonym: "D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity" RELATED []
synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287]
synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287]
xref: EC:1.1.1.287
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033711
name: 4-phosphoerythronate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH." [EC:1.1.1.290, RHEA:18829]
synonym: "4-O-phosphoerythronate dehydrogenase activity" RELATED [EC:1.1.1.290]
synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.290]
synonym: "4PE dehydrogenase activity" RELATED [EC:1.1.1.290]
synonym: "erythronate-4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.290]
synonym: "PdxB" RELATED [EC:1.1.1.290]
synonym: "PdxB 4PE dehydrogenase activity" RELATED [EC:1.1.1.290]
xref: EC:1.1.1.290
xref: KEGG_REACTION:R04210
xref: MetaCyc:ERYTHRON4PDEHYDROG-RXN
xref: RHEA:18829
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033712
name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH." [EC:1.1.1.292, RHEA:24208]
synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.292]
synonym: "AFR" RELATED [EC:1.1.1.292]
xref: EC:1.1.1.292
xref: KEGG_REACTION:R08194
xref: MetaCyc:1.1.1.292-RXN
xref: RHEA:24208
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033713
name: choline:oxygen 1-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide." [EC:1.1.3.17, RHEA:13505]
synonym: "choline oxidase activity" BROAD [EC:1.1.3.17]
xref: EC:1.1.3.17
xref: MetaCyc:CHOLINE-OXIDASE-RXN
xref: RHEA:13505
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033714
name: secondary-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: secondary alcohol + O2 = H2O2 + ketone." [EC:1.1.3.18, RHEA:23180]
synonym: "polyvinyl alcohol oxidase activity" RELATED [EC:1.1.3.18]
synonym: "secondary alcohol oxidase activity" RELATED [EC:1.1.3.18]
synonym: "secondary-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.18]
xref: EC:1.1.3.18
xref: KEGG_REACTION:R02277
xref: MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN
xref: RHEA:23180
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033715
name: nucleoside oxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28, RHEA:28651]
synonym: "nucleoside:oxygen 5'-oxidoreductase activity" RELATED [EC:1.1.3.28]
xref: EC:1.1.3.28
xref: MetaCyc:NUCLEOSIDE-OXIDASE-RXN
xref: RHEA:28651
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033716
name: nucleoside oxidase (hydrogen peroxide-forming) activity
namespace: molecular_function
def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide." [EC:1.1.3.39, RHEA:15489]
comment: Two other reactions might be associated with this activity: (1a) adenosine + O2 = 5'-dehydroadenosine + hydrogen peroxide, and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + hydrogen peroxide.
synonym: "nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity" RELATED [EC:1.1.3.39]
xref: EC:1.1.3.39
xref: MetaCyc:1.1.3.39-RXN
xref: RHEA:15489
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033717
name: gluconate 2-dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [RHEA:12769]
synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3]
synonym: "D-gluconate dehydrogenase activity" RELATED [EC:1.1.99.3]
synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" RELATED [EC:1.1.99.3]
synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.99.3]
synonym: "D-gluconate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.3]
synonym: "gluconate oxidase activity" RELATED [EC:1.1.99.3]
synonym: "gluconic acid dehydrogenase activity" RELATED [EC:1.1.99.3]
synonym: "gluconic dehydrogenase activity" RELATED [EC:1.1.99.3]
xref: EC:1.1.99.3
xref: MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN
xref: RHEA:12769
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0033718
name: pyranose dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29]
synonym: "PDH" RELATED [EC:1.1.99.29]
synonym: "pyranose dehydrogenase activity" RELATED [EC:1.1.99.29]
synonym: "pyranose-quinone oxidoreductase activity" RELATED [EC:1.1.99.29]
synonym: "pyranose:acceptor oxidoreductase activity" RELATED [EC:1.1.99.29]
synonym: "quinone-dependent pyranose dehydrogenase activity" RELATED [EC:1.1.99.29]
xref: EC:1.1.99.29
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033719
name: 2-oxo-acid reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30]
synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" RELATED [EC:1.1.99.30]
synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" RELATED [EC:1.1.99.30]
synonym: "2-oxoacid reductase activity" RELATED [EC:1.1.99.30]
synonym: "HVOR" RELATED [EC:1.1.99.30]
xref: EC:1.1.99.30
xref: MetaCyc:1.1.99.30-RXN
xref: RHEA:23664
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033720
name: (S)-mandelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31]
synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.31]
synonym: "L(+)-mandelate dehydrogenase activity" RELATED [EC:1.1.99.31]
synonym: "MDH" RELATED [EC:1.1.99.31]
xref: EC:1.1.99.31
xref: MetaCyc:MANDELATE-DEHYDROGENASE-RXN
xref: RHEA:15749
xref: UM-BBD_reactionID:r1048
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033721
name: aldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [RHEA:11888]
synonym: "aldehyde:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.4]
synonym: "NADP-acetaldehyde dehydrogenase activity" RELATED [EC:1.2.1.4]
synonym: "NADP-dependent aldehyde dehydrogenase activity" RELATED [EC:1.2.1.4]
xref: EC:1.2.1.4
xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:11888
is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0033722
name: malonate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15]
synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.15]
synonym: "malonic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.15]
xref: EC:1.2.1.15
xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033723
name: fluoroacetaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69]
synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.69]
xref: EC:1.2.1.69
xref: RHEA:16677
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0033726
name: aldehyde ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5]
synonym: "aldehyde:ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.5]
synonym: "AOR" RELATED [EC:1.2.7.5]
synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.5]
xref: EC:1.2.7.5
xref: MetaCyc:1.2.7.5-RXN
xref: RHEA:16421
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0033727
name: aldehyde dehydrogenase (FAD-independent) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7]
synonym: "aldehyde oxidoreductase activity" RELATED [EC:1.2.99.7]
synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" RELATED [EC:1.2.99.7]
synonym: "AORDd" RELATED [EC:1.2.99.7]
synonym: "Mop" RELATED [EC:1.2.99.7]
xref: EC:1.2.99.7
xref: MetaCyc:1.2.99.7-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0033728
name: divinyl chlorophyllide a 8-vinyl-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75]
synonym: "4VCR" RELATED [EC:1.3.1.75]
synonym: "[4-vinyl]chlorophyllide a reductase activity" RELATED [EC:1.3.1.75]
synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.75]
xref: EC:1.3.1.75
xref: MetaCyc:RXN-5286
xref: RHEA:14449
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033729
name: anthocyanidin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77]
synonym: "ANR" RELATED [EC:1.3.1.77]
synonym: "AtANR" RELATED [EC:1.3.1.77]
synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.3.1.77]
synonym: "MtANR" RELATED [EC:1.3.1.77]
xref: EC:1.3.1.77
xref: MetaCyc:RXN-10693
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033730
name: arogenate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78]
synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78]
synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" RELATED [EC:1.3.1.78]
synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78]
synonym: "TyrAa" RELATED [EC:1.3.1.78]
synonym: "TyrAAT1" RELATED [EC:1.3.1.78]
synonym: "TyrAAT2" RELATED [EC:1.3.1.78]
xref: EC:1.3.1.78
xref: MetaCyc:RXN-5682
xref: RHEA:15417
is_a: GO:0033731 ! arogenate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0033731
name: arogenate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79]
synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79]
synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" RELATED [EC:1.3.1.79]
synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79]
xref: EC:1.3.1.79
xref: MetaCyc:RXN-14476
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033732
name: pyrroloquinoline-quinone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone." [EC:1.3.3.11, RHEA:10692]
synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" RELATED [EC:1.3.3.11]
synonym: "PqqC" RELATED [EC:1.3.3.11]
xref: EC:1.3.3.11
xref: KEGG_REACTION:R07353
xref: MetaCyc:RXN-11181
xref: RHEA:10692
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0033734
name: (R)-benzylsuccinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.8.3]
synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" RELATED [EC:1.3.8.3]
synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" RELATED [EC:1.3.8.3]
synonym: "BbsG" RELATED [EC:1.3.8.3]
xref: EC:1.3.8.3
xref: RHEA:20876
xref: UM-BBD_reactionID:r0330
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

[Term]
id: GO:0033735
name: aspartate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0106351
alt_id: GO:0106352
def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21]
synonym: "aspartate dehydrogenase NAD activity" NARROW []
synonym: "aspartate dehydrogenase NADP activity" NARROW []
synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" RELATED []
synonym: "NAD-dependent aspartate dehydrogenase activity" RELATED [EC:1.4.1.21]
synonym: "NADH2-dependent aspartate dehydrogenase activity" RELATED [EC:1.4.1.21]
synonym: "NADP+-dependent aspartate dehydrogenase activity" RELATED [EC:1.4.1.21]
xref: EC:1.4.1.21
xref: KEGG_REACTION:R07164
xref: KEGG_REACTION:R07165
xref: MetaCyc:1.4.1.21-RXN
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0033736
name: L-lysine 6-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4+." [RHEA:22548]
synonym: "L-lysine-epsilon-oxidase activity" RELATED [EC:1.4.3.20]
synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" RELATED [EC:1.4.3.20]
synonym: "Lod" RELATED [EC:1.4.3.20]
synonym: "LodA" RELATED [EC:1.4.3.20]
synonym: "marinocine" RELATED [EC:1.4.3.20]
xref: EC:1.4.3.20
xref: KEGG_REACTION:R07598
xref: MetaCyc:1.4.3.20-RXN
xref: RHEA:22548
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0033737
name: obsolete 1-pyrroline dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [MetaCyc:1.5.1.35-RXN]
comment: This term was obsoleted because it represents the same reaction as aminobutyraldehyde dehydrogenase activity ; GO:0019145.
synonym: "1-pyrroline:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.35]
synonym: "ABALDH" RELATED [EC:1.5.1.35]
synonym: "gamma-aminobutyraldehyde dehydrogenase activity" RELATED [EC:1.5.1.35]
synonym: "YdcW" RELATED [EC:1.5.1.35]
is_obsolete: true
replaced_by: GO:0019145

[Term]
id: GO:0033738
name: methylenetetrahydrofolate reductase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1]
synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1]
synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" RELATED [EC:1.5.7.1]
xref: EC:1.5.7.1
xref: MetaCyc:RXN-5061
xref: RHEA:14229
is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0033739
name: preQ1 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH." [EC:1.7.1.13, RHEA:13409]
synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.7.1.13]
synonym: "7-cyano-7-deazaguanine reductase activity" RELATED [EC:1.7.1.13]
synonym: "preQ0 oxidoreductase activity" RELATED [EC:1.7.1.13]
synonym: "preQ0 reductase activity" RELATED [EC:1.7.1.13]
synonym: "QueF" RELATED [EC:1.7.1.13]
synonym: "queuine synthase activity" RELATED []
synonym: "queuine:NADP+ oxidoreductase activity" RELATED []
synonym: "YkvM" RELATED [EC:1.7.1.13]
xref: EC:1.7.1.13
xref: KEGG_REACTION:R07605
xref: MetaCyc:RXN0-4022
xref: RHEA:13409
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0033740
name: hydroxylamine oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.2.8]
synonym: "hydroxylamine:acceptor oxidoreductase activity" RELATED [EC:1.7.2.8]
xref: EC:1.7.2.8
xref: MetaCyc:1.7.99.8-RXN
xref: RHEA:23232
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033741
name: adenylyl-sulfate reductase (glutathione) activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + glutathione disulfide + H+ + sulfite = 5'-adenylyl sulfate + 2 glutathione." [EC:1.8.4.9, RHEA:14141]
synonym: "5'-adenylylsulfate reductase activity" RELATED [EC:1.8.4.9]
synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" RELATED [EC:1.8.4.9]
synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" RELATED [EC:1.8.4.9]
synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9]
xref: EC:1.8.4.9
xref: KEGG_REACTION:R05717
xref: MetaCyc:1.8.4.9-RXN
xref: RHEA:14141
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033743
name: peptide-methionine (R)-S-oxide reductase activity
namespace: molecular_function
alt_id: GO:0000318
def: "Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]
synonym: "methionine S-oxide reductase (R-form oxidizing) activity" RELATED [EC:1.8.4.12]
synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12]
synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12]
synonym: "MsrB" RELATED [EC:1.8.4.12]
synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" RELATED [EC:1.8.4.12]
synonym: "PilB" RELATED [EC:1.8.4.12]
synonym: "pMRsr" RELATED [EC:1.8.4.12]
synonym: "pMSR" RELATED [EC:1.8.4.12]
synonym: "protein-methionine-R-oxide reductase activity" EXACT []
synonym: "selenoprotein R" RELATED [EC:1.8.4.12]
synonym: "SelR" RELATED [EC:1.8.4.12]
synonym: "SelX" RELATED [EC:1.8.4.12]
xref: EC:1.8.4.12
xref: KEGG_REACTION:R07607
xref: MetaCyc:1.8.4.12-RXN
xref: Reactome:R-HSA-5676917 "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine"
xref: RHEA:24164
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033744
name: L-methionine:thioredoxin-disulfide S-oxidoreductase activity
namespace: molecular_function
alt_id: GO:0000317
def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13]
synonym: "acetylmethionine sulfoxide reductase activity" RELATED [EC:1.8.4.13]
synonym: "free-methionine (S)-S-oxide reductase activity" RELATED [EC:1.8.4.13]
synonym: "fSMsr" RELATED [EC:1.8.4.13]
synonym: "L-methionine-(S)-S-oxide reductase activity" NARROW [GOC:bf, GOC:vw]
synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" RELATED [EC:1.8.4.13]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13]
synonym: "methionine-S-oxide reductase activity" EXACT [PMID:11169920]
synonym: "methyl sulfoxide reductase I and II activity" RELATED [EC:1.8.4.13]
xref: EC:1.8.4.13
xref: KEGG_REACTION:R07606
xref: MetaCyc:1.8.4.13-RXN
xref: RHEA:19993
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033745
name: L-methionine-(R)-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14]
synonym: "free met-R-(o) reductase activity" RELATED [EC:1.8.4.14]
synonym: "free-methionine (R)-S-oxide reductase activity" RELATED [EC:1.8.4.14]
synonym: "FRMsr" RELATED [EC:1.8.4.14]
synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" RELATED [EC:1.8.4.14]
synonym: "methionine-R-sulfoxide reductase activity" RELATED []
xref: EC:1.8.4.14
xref: MetaCyc:1.8.4.14-RXN
xref: RHEA:21260
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033746
name: histone H3R2 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17947579, PMID:22483719, PMID:29233856]
synonym: "histone demethylase activity (H3-R2 specific)" EXACT []
synonym: "histone H3-methyl-arginine-2 demethylase activity" EXACT []
synonym: "histone H3-R2 demethylase activity" EXACT []
synonym: "histone H3R2me demethylase activity" EXACT []
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0141052 ! histone H3 demethylase activity

[Term]
id: GO:0033747
name: obsolete versatile peroxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: Reactive Black 5 + hydrogen peroxide = oxidized Reactive Black 5 + 2 H2O, and donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.16]
synonym: "hybrid peroxidase activity" RELATED [EC:1.11.1.16]
synonym: "polyvalent peroxidase activity" RELATED [EC:1.11.1.16]
synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.16]
synonym: "versatile peroxidase activity" EXACT []
synonym: "VP" RELATED [EC:1.11.1.16]
is_obsolete: true
replaced_by: GO:0004601
consider: GO:0052750

[Term]
id: GO:0033748
name: hydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6]
synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6]
synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6]
synonym: "hydrogen:(acceptor) oxidoreductase activity" RELATED [EC:1.12.99.6]
synonym: "hydrogen:acceptor oxidoreductase activity" RELATED [EC:1.12.99.6]
synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6]
synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6]
xref: EC:1.12.99.6
xref: MetaCyc:RXN0-4141
xref: RHEA:12116
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0033749
name: histone H4R3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17947579]
synonym: "histone demethylase activity (H4-R3 specific)" EXACT []
synonym: "histone H4-methyl-arginine-3 demethylase activity" EXACT []
synonym: "histone H4R3me demethylase activity" EXACT []
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0141058 ! histone H4 demethylase activity

[Term]
id: GO:0033750
name: ribosome localization
namespace: biological_process
alt_id: GO:0033753
def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "establishment of ribosome localisation" RELATED []
synonym: "establishment of ribosome localization" RELATED []
synonym: "ribosome localisation" RELATED []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0033751
name: obsolete linoleate 8R-lipoxygenase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [GOC:curators]
comment: The reason for obsoletion is because there is no support for the reaction. EC and RHEA mappings have been obsoleted at their source.
synonym: "5,8-linoleate diol synthase (bifunctional enzyme)" RELATED []
synonym: "7,8-linoleate diol synthase (bifunctional enzyme)" RELATED []
synonym: "linoleate diol synthase activity" RELATED []
is_obsolete: true

[Term]
id: GO:0033752
name: acetylacetone-cleaving enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50]
synonym: "acetylacetone dioxygenase activity" RELATED [EC:1.13.11.50]
synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50]
synonym: "acetylacetone:oxygen oxidoreductase activity" RELATED [EC:1.13.11.50]
synonym: "diketone cleaving dioxygenase activity" RELATED [EC:1.13.11.50]
synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50]
synonym: "Dke1" RELATED [EC:1.13.11.50]
xref: EC:1.13.11.50
xref: RHEA:12877
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033754
name: indoleamine 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine." [EC:1.13.11.52]
synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52]
synonym: "IDO" RELATED [EC:1.13.11.52]
synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52]
xref: EC:1.13.11.52
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033755
name: sulfur oxygenase/reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55, PMID:1522063]
synonym: "SOR" RELATED [EC:1.13.11.55]
synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55]
synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" RELATED [EC:1.13.11.55]
synonym: "sulphur oxygenase/reductase activity" EXACT []
xref: EC:1.13.11.55
xref: MetaCyc:1.13.11.55-RXN
xref: RHEA:13957
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033756
name: Oplophorus-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13]
synonym: "Oplophorus luciferase activity" RELATED [EC:1.13.12.13]
synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" RELATED [EC:1.13.12.13]
xref: EC:1.13.12.13
xref: MetaCyc:RXN-3361
xref: RHEA:20417
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0033757
name: glucoside 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13]
synonym: "D-aldohexopyranoside dehydrogenase" RELATED [EC:1.1.99.13]
synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" RELATED [EC:1.1.99.13]
synonym: "D-aldohexoside:acceptor 3-oxidoreductase" RELATED [EC:1.1.99.13]
synonym: "D-aldohexoside:cytochrome c oxidoreductase" RELATED [EC:1.1.99.13]
synonym: "hexopyranoside-cytochrome c oxidoreductase" RELATED [EC:1.1.99.13]
xref: EC:1.1.99.13
xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN
xref: RHEA:16589
xref: Wikipedia:Glucoside_3-dehydrogenase
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033758
name: clavaminate synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21]
synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21]
synonym: "clavaminic acid synthase activity" RELATED [EC:1.14.11.21]
synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.21]
xref: EC:1.14.11.21
xref: MetaCyc:1.14.11.21-RXN
xref: RHEA:20021
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0033759
name: flavone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.20.5]
synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" RELATED [EC:1.14.20.5]
synonym: "flavone synthase I activity" RELATED [EC:1.14.20.5]
synonym: "FNS I" RELATED [EC:1.14.20.5]
xref: EC:1.14.20.5
xref: MetaCyc:RXN-8000
xref: RHEA:10448
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0033760
name: 2'-deoxymugineic-acid 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + H+ + mugineate + succinate." [EC:1.14.11.24, RHEA:12200]
synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" RELATED [EC:1.14.11.24]
synonym: "IDS3" RELATED [EC:1.14.11.24]
xref: EC:1.14.11.24
xref: KEGG_REACTION:R07185
xref: MetaCyc:1.14.11.24-RXN
xref: RHEA:12200
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0033761
name: mugineic-acid 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: mugineate + 2-oxoglutarate + O2 = 3-epihydroxymugineate + CO2 + H+ + succinate. Also converts 2'-deoxymugineate to 3-epihydroxy-2'-deoxymugineate." [EC:1.14.11.25]
synonym: "IDS2" RELATED [EC:1.14.11.25]
synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.25]
xref: EC:1.14.11.25
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0033762
name: response to glucagon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl]
synonym: "response to glucagon stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0033763
name: proline 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28]
synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.28]
synonym: "P-3-H" RELATED [EC:1.14.11.28]
xref: EC:1.14.11.28
xref: MetaCyc:1.14.11.28-RXN
xref: RHEA:20265
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0033764
name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah]
xref: Reactome:R-HSA-9758682 "AKR1C1 hydrogenates PREDN,PREDL"
is_a: GO:0016229 ! steroid dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033765
name: steroid dehydrogenase activity, acting on the CH-CH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah]
is_a: GO:0016229 ! steroid dehydrogenase activity
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0033766
name: 2-hydroxyquinoline 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + quinolin-2-ol = H2O + NAD+ + quinoline-2,8-diol." [EC:1.14.13.61, RHEA:22080]
synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" RELATED [EC:1.14.13.61]
synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" RELATED [EC:1.14.13.61]
xref: EC:1.14.13.61
xref: KEGG_REACTION:R05158
xref: MetaCyc:1.14.13.61-RXN
xref: RHEA:22080
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033767
name: 4-hydroxyacetophenone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-hydroxyphenyl acetate + H2O + NADP+." [EC:1.14.13.84, RHEA:22916]
synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT systematic_synonym [EC:1.14.13.84]
synonym: "HAPMO" RELATED [EC:1.14.13.84]
xref: EC:1.14.13.84
xref: KEGG_REACTION:R06892
xref: MetaCyc:1.14.13.84-RXN
xref: RHEA:22916
xref: UM-BBD_reactionID:r0756
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033768
name: SUMO-targeted ubiquitin ligase complex
namespace: cellular_component
def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0033769
name: glyceollin synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin II or glyceollin III + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin I + NADP+ + 2 H2O." [EC:1.14.14.135]
synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" EXACT [EC:1.14.14.135]
xref: EC:1.14.14.135
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033770
name: 2-hydroxyisoflavanone synthase activity
namespace: molecular_function
alt_id: GO:0102604
alt_id: GO:0102668
def: "Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase]." [EC:1.14.14.87]
synonym: "isoflavonoid synthase" BROAD [EC:1.14.14.87]
xref: EC:1.14.14.87
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033771
name: flavanone 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [EC:1.14.14.162, RHEA:57584]
synonym: "licodione synthase activity" NARROW []
xref: EC:1.14.14.162
xref: KEGG_REACTION:R07198
xref: MetaCyc:RXN-19645
xref: RHEA:57584
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033772
name: flavonoid 3',5'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H+ + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]." [RHEA:55448]
synonym: "F3',5'H" RELATED [EC:1.14.14.81]
synonym: "F3'5'H" RELATED [EC:1.14.14.81]
synonym: "flavanone,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.81]
xref: EC:1.14.14.81
xref: MetaCyc:RXN-13192
xref: RHEA:55448
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033773
name: isoflavone 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [RHEA:18849]
synonym: "CYP Ge-3" RELATED [EC:1.14.14.90]
synonym: "CYP81E1" RELATED [EC:1.14.14.90]
synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.14.90]
xref: EC:1.14.14.90
xref: MetaCyc:RXN-11846
xref: RHEA:18849
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033774
name: basal labyrinth
namespace: cellular_component
def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0033775
name: deoxysarpagine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deoxysarpagine + H+ + NADPH + O2 = H2O + NADP+ + sarpagine." [EC:1.14.14.136, RHEA:14237]
synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" RELATED [EC:1.14.14.136]
synonym: "DOSH" RELATED [EC:1.14.14.136]
xref: EC:1.14.14.136
xref: KEGG_REACTION:R05828
xref: MetaCyc:1.14.13.91-RXN
xref: RHEA:14237
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033776
name: phenylacetone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+." [EC:1.14.13.92, RHEA:10124]
synonym: "PAMO" RELATED [EC:1.14.13.92]
synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.13.92]
xref: EC:1.14.13.92
xref: KEGG_REACTION:R07201
xref: MetaCyc:1.14.13.92-RXN
xref: RHEA:10124
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033777
name: lithocholate 6beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + lithocholate + NADPH + O2 = 6-beta-hydroxylithocholate + H2O + NADP+." [EC:1.14.14.138, RHEA:18857]
synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.14.138]
synonym: "CYP3A10" RELATED [EC:1.14.14.138]
synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" RELATED [EC:1.14.14.138]
synonym: "lithocholate 6beta-monooxygenase activity" RELATED [EC:1.14.14.138]
synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" RELATED [EC:1.14.14.138]
xref: EC:1.14.14.138
xref: KEGG_REACTION:R07203
xref: MetaCyc:1.14.13.94-RXN
xref: RHEA:18857
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033778
name: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+." [PMID:10051404, PMID:1400444, RHEA:46752]
xref: KEGG_REACTION:R04826
xref: MetaCyc:1.14.13.95-RXN
xref: Reactome:R-HSA-192157 "CYP8B1 12-hydroxylates 4CHOL7aOLONE"
xref: Reactome:R-HSA-193709 "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL"
xref: Reactome:R-HSA-193845 "CYP8B1 12-hydroxylates 4CHOL7a,27DONE"
xref: RHEA:46752
is_a: GO:0008397 ! sterol 12-alpha-hydroxylase activity

[Term]
id: GO:0033779
name: 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+." [RHEA:15261]
synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" RELATED [EC:1.14.14.139]
synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" RELATED [EC:1.14.14.139]
xref: KEGG_REACTION:R07204
xref: MetaCyc:1.14.13.96-RXN
xref: RHEA:15261
is_a: GO:0008397 ! sterol 12-alpha-hydroxylase activity

[Term]
id: GO:0033780
name: taurochenodeoxycholate 6alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: taurochenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] +  = taurohyocholate H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate." [EC:1.14.14.57]
synonym: "CYP3A4" RELATED [EC:1.14.14.57]
synonym: "CYP4A21" RELATED [EC:1.14.14.57]
synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" RELATED [EC:1.14.14.57]
synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" RELATED []
xref: EC:1.14.14.57
xref: MetaCyc:RXN-7977
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033781
name: cholesterol 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]
synonym: "cholesterol 24-monooxygenase activity" RELATED [EC:1.14.14.25]
synonym: "cholesterol 24S-hydroxylase activity" RELATED [EC:1.14.14.25]
synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" RELATED [EC:1.14.14.25]
synonym: "CYP46" RELATED [EC:1.14.14.25]
synonym: "CYP46A1" RELATED [EC:1.14.14.25]
synonym: "cytochrome P450 46A1" RELATED [EC:1.14.14.25]
xref: EC:1.14.14.25
xref: KEGG_REACTION:R07207
xref: MetaCyc:1.14.13.98-RXN
xref: Reactome:R-HSA-192061 "CYP46A1 24-hydroxylates CHOL"
xref: RHEA:22716
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033782
name: 24S-hydroxycholesterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [PMID:10748047, PMID:11013305, RHEA:46124]
synonym: "24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED []
synonym: "24-hydroxycholesterol 7alpha-hydroxylase activity" BROAD []
synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.26]
xref: EC:1.14.14.26
xref: KEGG_REACTION:R07208
xref: MetaCyc:1.14.13.99-RXN
xref: RHEA:46124
is_a: GO:0008387 ! steroid 7-alpha-hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033783
name: 25-hydroxycholesterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Also converts (25R)-cholest-5-ene-3beta,26-diol to (25R)-cholest-5-en-3beta,7alpha,26-triol." [EC:1.14.14.29]
synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.29]
synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED [EC:1.14.14.29]
synonym: "CYP7B1" RELATED [EC:1.14.14.29]
synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" RELATED [EC:1.14.14.29]
xref: EC:1.14.14.29
is_a: GO:0008387 ! steroid 7-alpha-hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033784
name: senecionine N-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + senecionine = H2O + NADP+ + senecionine N-oxide." [EC:1.14.13.101, RHEA:11420]
synonym: "senecionine monooxygenase (N-oxide-forming) activity" RELATED [EC:1.14.13.101]
synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" RELATED [EC:1.14.13.101]
synonym: "SNO" RELATED [EC:1.14.13.101]
xref: EC:1.14.13.101
xref: KEGG_REACTION:R07373
xref: MetaCyc:1.14.13.101-RXN
xref: RHEA:11420
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033785
name: heptose 7-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [RHEA:27473]
synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT []
xref: EC:2.7.1.167
xref: MetaCyc:RXN0-4341
xref: RHEA:27473
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033786
name: heptose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342]
synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT []
synonym: "heptose 1-phosphate adenyltransferase activity" EXACT []
xref: MetaCyc:RXN0-4342
xref: RHEA:27465
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0033787
name: cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH." [RHEA:16113]
synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" RELATED [EC:1.16.1.6]
synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" RELATED [EC:1.16.1.6]
synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" RELATED [EC:1.16.1.6]
synonym: "cyanocobalamin reductase activity" RELATED [EC:1.16.1.6]
synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" RELATED [EC:1.16.1.6]
synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" RELATED [EC:1.16.1.6]
xref: EC:1.16.1.6
xref: KEGG_REACTION:R02999
xref: MetaCyc:1.6.99.12-RXN
xref: Reactome:R-HSA-3149519 "MMACHC decyanates CNCbl"
xref: RHEA:16113
is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[Term]
id: GO:0033788
name: leucoanthocyanidin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3]
synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" RELATED [EC:1.17.1.3]
synonym: "leucocyanidin reductase activity" RELATED [EC:1.17.1.3]
xref: EC:1.17.1.3
xref: MetaCyc:RXN-1484
xref: RHEA:10616
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0033789
name: phenylacetyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1,4-benzoquinone + H2O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA." [RHEA:15705]
synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" RELATED [EC:1.17.5.1]
synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" RELATED [EC:1.17.5.1]
xref: EC:1.17.5.1
xref: KEGG_REACTION:R07222
xref: MetaCyc:1.17.5.1-RXN
xref: RHEA:15705
is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

[Term]
id: GO:0033790
name: hydroxymethylfurfural reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033791
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3]
synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" RELATED [EC:1.17.99.3]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" RELATED [EC:1.17.99.3]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" RELATED [EC:1.17.99.3]
synonym: "THC-CoA oxidase activity" RELATED [EC:1.17.99.3]
synonym: "THCA-CoA oxidase activity" RELATED [EC:1.17.99.3]
synonym: "trihydroxycoprostanoyl-CoA oxidase activity" RELATED [EC:1.17.99.3]
xref: EC:1.17.99.3
xref: MetaCyc:1.17.99.3-RXN
xref: RHEA:15733
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033792
name: 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH." [PMID:23836456, RHEA:55380]
comment: Note that this was originally described as bile acid 7-dehydroxylase (PubMed:3549693). In fact, the 7-dehydroxylation process is catalyzed by multiple enzymes.
synonym: "7alpha-dehydroxylase activity" RELATED []
synonym: "bile acid 7-dehydroxylase activity" RELATED []
synonym: "bile-acid 7alpha-dehydroxylase activity" RELATED []
synonym: "cholate 7alpha-dehydroxylase activity" RELATED []
xref: EC:1.1.1.395
xref: RHEA:55380
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033793
name: aureusidin synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+ + O2 = aureusidin 6-O-beta-glucoside + H2O, 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H+ + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O, and 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H+ + O2 = bracteatin 6-O-beta-glucoside + H2O. This activity consists of two separate chemical transformations: 3-hydroxylation and oxidative cyclization (2',-dehydrogenation)." [EC:1.21.3.6]
synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" RELATED [EC:1.21.3.6]
xref: EC:1.21.3.6
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0033794
name: sarcosine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3]
synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" RELATED [EC:1.21.4.3]
xref: EC:1.21.4.3
xref: RHEA:12825
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0033795
name: betaine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H+ + phosphate." [RHEA:11848]
synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" RELATED [EC:1.21.4.4]
xref: EC:1.21.4.4
xref: RHEA:11848
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0033796
name: sulfur reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide, H2 + n sulfur = H+ + hydrogen sulfide + (n-1) sulfur." [RHEA:35591]
synonym: "(donor):sulfur oxidoreductase activity" RELATED [EC:1.12.98.4]
synonym: "sulphur reductase activity" EXACT []
xref: EC:1.12.98.4
xref: MetaCyc:RXN-8269
xref: RHEA:35591
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033797
name: selenate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 e(-) + 2 H+ + selenate = H2O + selenite." [RHEA:14029]
synonym: "selenite:reduced acceptor oxidoreductase activity" RELATED [EC:1.97.1.9]
xref: EC:1.97.1.9
xref: KEGG_REACTION:R07229
xref: MetaCyc:RXN0-2101
xref: RHEA:14029
xref: UM-BBD_reactionID:r0828
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033798
name: thyroxine 5-deiodinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.21.99.3]
synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" RELATED [EC:1.21.99.3]
synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.21.99.3]
synonym: "inner ring-deiodinating pathway" EXACT [PMID:20403357]
synonym: "iodothyronine 5-deiodinase activity" RELATED [EC:1.21.99.3]
synonym: "iodothyronine inner ring monodeiodinase activity" RELATED [EC:1.21.99.3]
synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.21.99.3]
xref: EC:1.21.99.3
xref: MetaCyc:1.97.1.11-RXN
xref: RHEA:18897
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033799
name: myricetin 3'-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0102437
def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [RHEA:25629]
synonym: "CrCOMT2" RELATED []
synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED []
synonym: "myricetin 3-O-methyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED []
xref: KEGG_REACTION:R06815
xref: MetaCyc:RXN-8451
xref: RHEA:25629
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033800
name: isoflavone 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150]
synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" RELATED [EC:2.1.1.150]
xref: EC:2.1.1.150
xref: MetaCyc:RXN-6241
xref: RHEA:17933
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033801
name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153]
synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" RELATED [EC:2.1.1.153]
xref: EC:2.1.1.153
xref: MetaCyc:RXN-4981
xref: RHEA:11432
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033802
name: isoliquiritigenin 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.154, RHEA:21608]
synonym: "chalcone OMT" RELATED [EC:2.1.1.154]
synonym: "CHMT" RELATED [EC:2.1.1.154]
synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" RELATED [EC:2.1.1.154]
xref: EC:2.1.1.154
xref: KEGG_REACTION:R07242
xref: MetaCyc:RXN-3501
xref: RHEA:21608
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033803
name: kaempferol 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H+ + kaempferide." [RHEA:15105]
synonym: "F 4'-OMT" RELATED [EC:2.1.1.155]
synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" RELATED [EC:2.1.1.155]
synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.155]
xref: EC:2.1.1.155
xref: KEGG_REACTION:R06807
xref: MetaCyc:2.1.1.155-RXN
xref: RHEA:15105
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033804
name: obsolete glycine/sarcosine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine, and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "ApGSMT" RELATED [EC:2.1.1.156]
synonym: "glycine sarcosine N-methyltransferase activity" RELATED [EC:2.1.1.156]
synonym: "glycine-sarcosine methyltransferase activity" RELATED [EC:2.1.1.156]
synonym: "glycine/sarcosine N-methyltransferase activity" EXACT []
synonym: "GMT" RELATED [EC:2.1.1.156]
synonym: "GSMT" RELATED [EC:2.1.1.156]
synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" RELATED [EC:2.1.1.156]
is_obsolete: true
consider: GO:0017174
consider: GO:0052730

[Term]
id: GO:0033805
name: obsolete sarcosine/dimethylglycine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine, and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [GOC:curators]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "ApDMT" RELATED [EC:2.1.1.157]
synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157]
synonym: "sarcosine dimethylglycine methyltransferase activity" NARROW [EC:2.1.1.157]
synonym: "sarcosine dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157]
synonym: "sarcosine/dimethylglycine N-methyltransferase activity" EXACT []
synonym: "SDMT" RELATED [EC:2.1.1.157]
is_obsolete: true
consider: GO:0052729
consider: GO:0052730

[Term]
id: GO:0033806
name: fluorothreonine transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [RHEA:11748]
synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" RELATED [EC:2.2.1.8]
xref: EC:2.2.1.8
xref: RHEA:11748
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0033807
name: obsolete icosanoyl-CoA synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [GOC:curators]
comment: This term was obsoleted because the it was obsoleted by the authoritative databases, EC and MetaCyc.
synonym: "acyl-CoA elongase activity" RELATED []
synonym: "C18-CoA elongase activity" RELATED []
synonym: "stearoyl-CoA elongase activity" RELATED []
synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" RELATED []
is_obsolete: true
consider: GO:0009922
consider: GO:0102158
consider: GO:0102758
consider: GO:0141040

[Term]
id: GO:0033808
name: 6'-deoxychalcone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" RELATED [EC:2.3.1.170]
xref: EC:2.3.1.170
xref: MetaCyc:RXN-3142
xref: RHEA:10584
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0033809
name: anthocyanin 6''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [RHEA:16025]
synonym: "3MaT" RELATED [EC:2.3.1.171]
synonym: "Dv3MaT" RELATED [EC:2.3.1.171]
synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.171]
synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.171]
xref: EC:2.3.1.171
xref: MetaCyc:2.3.1.171-RXN
xref: RHEA:16025
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0033810
name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172]
synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" RELATED [EC:2.3.1.172]
synonym: "Ss5MaT1" RELATED [EC:2.3.1.172]
xref: EC:2.3.1.172
xref: MetaCyc:2.3.1.172-RXN
xref: RHEA:21988
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0033811
name: flavonol-3-O-triglucoside O-coumaroyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173]
synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" RELATED [EC:2.3.1.173]
xref: EC:2.3.1.173
xref: MetaCyc:2.3.1.173-RXN
xref: RHEA:22160
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0033812
name: 3-oxoadipyl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [RHEA:19481]
synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" RELATED [EC:2.3.1.174]
xref: EC:2.3.1.174
xref: MetaCyc:RXN-3641
xref: RHEA:19481
is_a: GO:0003988 ! acetyl-CoA C-acyltransferase activity

[Term]
id: GO:0033813
name: deacetylcephalosporin-C acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA." [EC:2.3.1.175, RHEA:23860]
synonym: "acetyl coenzyme A:DAC acetyltransferase activity" RELATED [EC:2.3.1.175]
synonym: "acetyl-CoA:DAC acetyltransferase activity" RELATED [EC:2.3.1.175]
synonym: "acetyl-CoA:DAC O-acetyltransferase activity" RELATED [EC:2.3.1.175]
synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" RELATED [EC:2.3.1.175]
synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" RELATED [EC:2.3.1.175]
synonym: "cefG" RELATED [EC:2.3.1.175]
synonym: "CPC acetylhydrolase activity" RELATED [EC:2.3.1.175]
synonym: "DAC acetyltransferase activity" RELATED [EC:2.3.1.175]
synonym: "DAC-AT" RELATED [EC:2.3.1.175]
synonym: "deacetylcephalosporin C acetyltransferase activity" RELATED [EC:2.3.1.175]
xref: EC:2.3.1.175
xref: KEGG_REACTION:R03064
xref: MetaCyc:2.3.1.175-RXN
xref: RHEA:23860
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0033814
name: propanoyl-CoA C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA." [RHEA:16865]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" RELATED [EC:2.3.1.176]
synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176]
synonym: "PTE-2" RELATED [EC:2.3.1.176]
synonym: "SCP-X" RELATED [EC:2.3.1.176]
synonym: "SCPchi" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176]
xref: MetaCyc:2.3.1.176-RXN
xref: RHEA:16865
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0033815
name: biphenyl synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177]
synonym: "BIS" RELATED [EC:2.3.1.177]
synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" RELATED [EC:2.3.1.177]
xref: EC:2.3.1.177
xref: MetaCyc:2.3.1.177-RXN
xref: RHEA:22292
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0033816
name: diaminobutyrate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H+." [EC:2.3.1.178, RHEA:16901]
synonym: "2,4-diaminobutanoate acetyltransferase activity" RELATED [EC:2.3.1.178]
synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" RELATED [EC:2.3.1.178]
synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" RELATED [EC:2.3.1.178]
synonym: "DAB acetyltransferase activity" RELATED [EC:2.3.1.178]
synonym: "DABA acetyltransferase activity" RELATED [EC:2.3.1.178]
synonym: "DABAcT" RELATED [EC:2.3.1.178]
synonym: "diaminobutyric acid acetyltransferase activity" RELATED [EC:2.3.1.178]
synonym: "EctA" RELATED [EC:2.3.1.178]
synonym: "L-2,4-diaminobutanoate acetyltransferase activity" RELATED [EC:2.3.1.178]
synonym: "L-2,4-diaminobutyrate acetyltransferase activity" RELATED [EC:2.3.1.178]
xref: EC:2.3.1.178
xref: KEGG_REACTION:R06978
xref: MetaCyc:R102-RXN
xref: RHEA:16901
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0033818
name: beta-ketoacyl-acyl-carrier-protein synthase III activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.180]
synonym: "3-ketoacyl-acyl carrier protein synthase III activity" RELATED [EC:2.3.1.180]
synonym: "3-oxoacyl:ACP synthase III activity" RELATED [EC:2.3.1.180]
synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" RELATED [EC:2.3.1.180]
synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" RELATED [EC:2.3.1.180]
synonym: "beta-ketoacyl-ACP synthase III activity" RELATED [EC:2.3.1.180]
synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" RELATED [EC:2.3.1.180]
synonym: "FabH" RELATED [EC:2.3.1.180]
synonym: "KAS III" RELATED [EC:2.3.1.180]
synonym: "KASIII" RELATED [EC:2.3.1.180]
xref: EC:2.3.1.180
xref: MetaCyc:2.3.1.180-RXN
xref: RHEA:12080
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0033819
name: lipoyl(octanoyl) transferase activity
namespace: molecular_function
alt_id: GO:0102555
def: "Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]." [RHEA:17665]
synonym: "lipoate/octanoate transferase activity" EXACT [EC:2.3.1.181]
synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" EXACT [EC:2.3.1.181]
synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl transferase activity (acting on glycine-cleavage complex H protein)" NARROW []
synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
xref: EC:2.3.1.181
xref: MetaCyc:RXN0-947
xref: Reactome:R-HSA-6793590 "LIPT2 transfers octanoyl group to GCSH"
xref: RHEA:17665
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0033820
name: DNA alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.26]
synonym: "T2-HMC-alpha-glucosyl transferase activity" RELATED [EC:2.4.1.26]
synonym: "T4-HMC-alpha-glucosyl transferase activity" RELATED [EC:2.4.1.26]
synonym: "T6-HMC-alpha-glucosyl transferase activity" RELATED [EC:2.4.1.26]
synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.26]
synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" RELATED [EC:2.4.1.26]
synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" RELATED [EC:2.4.1.26]
xref: EC:2.4.1.26
xref: MetaCyc:2.4.1.26-RXN
is_a: GO:0046527 ! glucosyltransferase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0033821
name: DNA beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.27]
synonym: "T4 phage beta-glucosyltransferase activity" RELATED [EC:2.4.1.27]
synonym: "T4-beta-glucosyl transferase activity" RELATED [EC:2.4.1.27]
synonym: "T4-HMC-beta-glucosyl transferase activity" RELATED [EC:2.4.1.27]
synonym: "UDP glucose-DNA beta-glucosyltransferase activity" RELATED [EC:2.4.1.27]
synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.27]
synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.27]
synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" RELATED [EC:2.4.1.27]
xref: EC:2.4.1.27
xref: MetaCyc:2.4.1.27-RXN
is_a: GO:0046527 ! glucosyltransferase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0033822
name: glucosyl-DNA beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28]
synonym: "T6-beta-glucosyl transferase activity" RELATED [EC:2.4.1.28]
synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" RELATED [EC:2.4.1.28]
synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.28]
synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.28]
synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" RELATED [EC:2.4.1.28]
xref: EC:2.4.1.28
xref: MetaCyc:2.4.1.28-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033823
name: procollagen glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66]
synonym: "collagen glucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "collagen hydroxylysyl glucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "galactosylhydroxylysine glucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "galactosylhydroxylysine-glucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "galactosylhydroxylysyl glucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "UDP-glucose-collagenglucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" RELATED [EC:2.4.1.66]
synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" RELATED [EC:2.4.1.66]
xref: EC:2.4.1.66
xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-1981157 "Glucosylation of collagen propeptide hydroxylysines"
xref: RHEA:12576
is_a: GO:0046527 ! glucosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0033824
name: obsolete alternansucrase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as dextransucrase activity ; GO:0047849.
is_obsolete: true
replaced_by: GO:0047849

[Term]
id: GO:0033825
name: oligosaccharide 4-alpha-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161]
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.161]
synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" RELATED [EC:2.4.1.161]
synonym: "amylase III activity" RELATED [EC:2.4.1.161]
xref: EC:2.4.1.161
xref: MetaCyc:2.4.1.161-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033826
name: xyloglucan 4-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168]
synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.168]
synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.168]
synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" RELATED [EC:2.4.1.168]
synonym: "xyloglucan 4beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.168]
synonym: "xyloglucan glucosyltransferase activity" RELATED [EC:2.4.1.168]
xref: EC:2.4.1.168
xref: MetaCyc:RXN-12419
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033827
name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197]
synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197]
synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197]
synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197]
synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197]
xref: EC:2.4.1.197
xref: MetaCyc:2.4.1.197-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033828
name: glucosylglycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H+." [EC:2.4.1.213, RHEA:12881]
synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.213]
synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.213]
synonym: "GG-phosphate synthase activity" RELATED [EC:2.4.1.213]
synonym: "GGPS" RELATED [EC:2.4.1.213]
synonym: "glucosyl-glycerol-phosphate synthase activity" RELATED [EC:2.4.1.213]
xref: EC:2.4.1.213
xref: KEGG_REACTION:R05328
xref: MetaCyc:2.4.1.213-RXN
xref: RHEA:12881
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033829
name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222]
synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.222]
synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.222]
xref: EC:2.4.1.222
xref: MetaCyc:2.4.1.222-RXN
xref: Reactome:R-HSA-1912355 "Glycosylation of Pre-NOTCH by FRINGE"
xref: Reactome:R-HSA-5096538 "Defective LFNG does not transfer GlcNAc to Pre-NOTCH"
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033830
name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229]
synonym: "Skp1-HyPro GlcNAc-transferase activity" RELATED [EC:2.4.1.229]
synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" RELATED [EC:2.4.1.229]
synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" RELATED [EC:2.4.1.229]
synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" RELATED [EC:2.4.1.229]
synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" RELATED [EC:2.4.1.229]
xref: EC:2.4.1.229
xref: RHEA:17841
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0033831
name: kojibiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.230, RHEA:11176]
synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.230]
xref: EC:2.4.1.230
xref: KEGG_REACTION:R07264
xref: MetaCyc:2.4.1.230-RXN
xref: RHEA:11176
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033832
name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [RHEA:16257]
synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.231]
synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231]
xref: EC:2.4.1.231
xref: MetaCyc:RXN-4441
xref: RHEA:16257
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033833
name: hydroxymethylfurfural reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
xref: MetaCyc:RXN-10738
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033834
name: kaempferol 3-O-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [RHEA:15709]
synonym: "F3GalTase activity" RELATED [EC:2.4.1.234]
synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.234]
xref: EC:2.4.1.234
xref: MetaCyc:2.4.1.234-RXN
xref: RHEA:15709
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0033835
name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236]
synonym: "1->2 UDP-rhamnosyltransferase activity" RELATED [EC:2.4.1.236]
synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" RELATED [EC:2.4.1.236]
synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" RELATED [EC:2.4.1.236]
xref: EC:2.4.1.236
xref: MetaCyc:RXN-5001
xref: RHEA:15473
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0033836
name: flavonol 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237]
synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.237]
synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.237]
xref: EC:2.4.1.237
xref: MetaCyc:2.4.1.237-RXN
xref: RHEA:23164
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033837
name: anthocyanin 3'-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238]
synonym: "3'GT" RELATED [EC:2.4.1.238]
synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.238]
synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" RELATED [EC:2.4.1.238]
xref: EC:2.4.1.238
xref: MetaCyc:RXN-8231
xref: RHEA:35627
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033838
name: flavonol-3-O-glucoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239]
synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.239]
xref: EC:2.4.1.239
xref: MetaCyc:2.4.1.239-RXN
xref: RHEA:18893
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033839
name: flavonol-3-O-glycoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240]
synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.240]
xref: EC:2.4.1.240
xref: MetaCyc:2.4.1.240-RXN
xref: RHEA:23544
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033840
name: alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H+, where NDP is ADP or UDP." [EC:2.4.1.242, PMID:17472966, RHEA:15873]
synonym: "GBSS" RELATED [EC:2.4.1.242]
synonym: "GBSSI" RELATED [EC:2.4.1.242]
synonym: "GBSSII" RELATED [EC:2.4.1.242]
synonym: "granule-bound starch synthase activity" RELATED [EC:2.4.1.242]
synonym: "granule-bound starch synthase I activity" RELATED [EC:2.4.1.242]
synonym: "granule-bound starch synthase II activity" RELATED [EC:2.4.1.242]
synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.242]
synonym: "NDPglucose-starch glucosyltransferase activity" RELATED [EC:2.4.1.242]
synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" RELATED [EC:2.4.1.242]
synonym: "starch synthase II activity" RELATED [EC:2.4.1.242]
synonym: "waxy protein" RELATED [EC:2.4.1.242]
xref: EC:2.4.1.242
xref: MetaCyc:2.4.1.242-RXN
xref: RHEA:15873
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033841
name: 6G-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243]
synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" RELATED [EC:2.4.1.243]
synonym: "6G-FFT" RELATED [EC:2.4.1.243]
synonym: "6G-fructotransferase activity" RELATED [EC:2.4.1.243]
synonym: "6G-FT" RELATED [EC:2.4.1.243]
synonym: "fructan:fructan 6G-fructosyltransferase activity" RELATED [EC:2.4.1.243]
xref: EC:2.4.1.243
xref: MetaCyc:2.4.1.243-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0033842
name: N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H+." [RHEA:20493]
synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" RELATED [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" RELATED [EC:2.4.1.244]
synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244]
synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244]
synonym: "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.244]
xref: EC:2.4.1.244
xref: MetaCyc:2.4.1.244-RXN
xref: RHEA:20493
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0033843
name: xyloglucan 6-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39]
synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" RELATED [EC:2.4.2.39]
synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" RELATED [EC:2.4.2.39]
synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" RELATED [EC:2.4.2.39]
xref: EC:2.4.2.39
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0033844
name: galactose-6-sulfurylase activity
namespace: molecular_function
def: "Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5]
synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" RELATED [EC:2.5.1.5]
synonym: "galactose 6-sulfatase activity" RELATED [EC:2.5.1.5]
synonym: "galactose-6-sulfatase activity" RELATED [EC:2.5.1.5]
synonym: "porphyran sulfatase activity" RELATED [EC:2.5.1.5]
xref: EC:2.5.1.5
xref: MetaCyc:2.5.1.5-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033845
name: hydroxymethylfurfural reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033846
name: adenosyl-fluoride synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63]
synonym: "fluorinase activity" RELATED [EC:2.5.1.63]
synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" RELATED [EC:2.5.1.63]
xref: EC:2.5.1.63
xref: MetaCyc:2.5.1.63-RXN
xref: RHEA:16661
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033847
name: O-phosphoserine sulfhydrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65]
synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.65]
synonym: "O-phosphoserine(thiol)-lyase activity" RELATED [EC:2.5.1.65]
xref: EC:2.5.1.65
xref: MetaCyc:2.5.1.65-RXN
xref: RHEA:10252
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033848
name: N2-(2-carboxyethyl)arginine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H+ + phosphate." [EC:2.5.1.66, RHEA:10556]
synonym: "CEA synthetase activity" RELATED [EC:2.5.1.66]
synonym: "CEAS" RELATED [EC:2.5.1.66]
synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" RELATED [EC:2.5.1.66]
synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" RELATED [EC:2.5.1.66]
synonym: "N2-(2-carboxyethyl)arginine synthetase activity" RELATED [EC:2.5.1.66]
xref: EC:2.5.1.66
xref: KEGG_REACTION:R05465
xref: MetaCyc:2.5.1.66-RXN
xref: RHEA:10556
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033849
name: chrysanthemyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate." [EC:2.5.1.67, RHEA:14009]
synonym: "CPPase activity" RELATED [EC:2.5.1.67]
synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" RELATED [EC:2.5.1.67]
xref: EC:2.5.1.67
xref: KEGG_REACTION:R08948
xref: MetaCyc:2.5.1.67-RXN
xref: RHEA:14009
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033850
name: Z-farnesyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.68, RHEA:23300]
synonym: "(Z)-farnesyl diphosphate synthase activity" RELATED [EC:2.5.1.68]
synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" RELATED [EC:2.5.1.68]
xref: EC:2.5.1.68
xref: KEGG_REACTION:R08528
xref: MetaCyc:2.5.1.68-RXN
xref: RHEA:23300
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033851
name: lavandulyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69, RHEA:21676]
synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" RELATED [EC:2.5.1.69]
synonym: "FDS-5" RELATED [EC:2.5.1.69]
xref: EC:2.5.1.69
xref: KEGG_REACTION:R08950
xref: MetaCyc:2.5.1.69-RXN
xref: RHEA:21676
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033852
name: thyroid-hormone transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate." [EC:2.6.1.26, RHEA:19133]
synonym: "3,5-dinitrotyrosine aminotransferase activity" RELATED [EC:2.6.1.26]
synonym: "3,5-dinitrotyrosine transaminase activity" RELATED [EC:2.6.1.26]
synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.26]
synonym: "thyroid hormone aminotransferase activity" RELATED [EC:2.6.1.26]
synonym: "thyroid-hormone aminotransferase activity" RELATED [EC:2.6.1.26]
xref: EC:2.6.1.26
xref: KEGG_REACTION:R03952
xref: MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN
xref: RHEA:19133
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033853
name: aspartate-prephenate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [RHEA:20445]
synonym: "L-arogenate:oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.78]
synonym: "L-aspartate:prephenate aminotransferase activity" RELATED [EC:2.6.1.78]
synonym: "PAT" RELATED [EC:2.6.1.78]
synonym: "prephenate aspartate aminotransferase activity" RELATED [EC:2.6.1.78]
synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78]
xref: EC:2.6.1.78
xref: MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN
xref: RHEA:20445
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033854
name: glutamate-prephenate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate." [EC:2.6.1.79, RHEA:22880]
synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.79]
synonym: "L-glutamate:prephenate aminotransferase activity" RELATED [EC:2.6.1.79]
synonym: "PAT" RELATED [EC:2.6.1.79]
synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79]
xref: EC:2.6.1.79
xref: KEGG_REACTION:R07276
xref: MetaCyc:PREPHENATE-TRANSAMINE-RXN
xref: RHEA:22880
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033855
name: nicotianamine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80, RHEA:22104]
synonym: "NAAT" RELATED [EC:2.6.1.80]
synonym: "NAAT-I" RELATED [EC:2.6.1.80]
synonym: "NAAT-II" RELATED [EC:2.6.1.80]
synonym: "NAAT-III" RELATED [EC:2.6.1.80]
synonym: "nicotianamine transaminase activity" RELATED [EC:2.6.1.80]
synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.80]
xref: EC:2.6.1.80
xref: KEGG_REACTION:R07277
xref: MetaCyc:2.6.1.80-RXN
xref: RHEA:22104
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033856
name: pyridoxine 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H2O + H+ + phosphate + pyridoxine 5'-phosphate." [RHEA:15265]
synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" RELATED [EC:2.6.99.2]
synonym: "PNP synthase activity" RELATED [EC:2.6.99.2]
synonym: "pyridoxine 5-phosphate phospho lyase activity" RELATED [EC:2.6.99.2]
xref: EC:2.6.99.2
xref: KEGG_REACTION:R05838
xref: MetaCyc:PDXJ-RXN
xref: RHEA:15265
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0033857
name: 5-diphosphoinositol pentakisphosphate 1-kinase activity
namespace: molecular_function
alt_id: GO:0102092
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate." [EC:2.7.4.24]
synonym: "diphosphoinositol-pentakisphosphate kinase activity" BROAD []
synonym: "inositol heptakisphosphate 1-kinase activity" BROAD []
synonym: "PP-InsP5 kinase activity" RELATED [EC:2.7.4.24]
synonym: "PP-IP5 kinase activity" RELATED [EC:2.7.4.24]
synonym: "PPIP5K" RELATED []
xref: MetaCyc:2.7.4.24-RXN
is_a: GO:0000829 ! diphosphoinositol pentakisphosphate kinase activity

[Term]
id: GO:0033858
name: N-acetylgalactosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157]
synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" RELATED [EC:2.7.1.157]
synonym: "GALK2" RELATED [EC:2.7.1.157]
synonym: "GalNAc kinase activity" RELATED [EC:2.7.1.157]
synonym: "GK2" RELATED [EC:2.7.1.157]
synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" RELATED [EC:2.7.1.157]
xref: EC:2.7.1.157
xref: MetaCyc:2.7.1.157-RXN
xref: RHEA:12617
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033859
name: furaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass." [GOC:jp, PMID:15338422, PMID:16652391]
is_a: GO:0006081 ! aldehyde metabolic process

[Term]
id: GO:0033860
name: regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0033861
name: negative regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of NAD(P)H oxidase activity" EXACT []
synonym: "down-regulation of NAD(P)H oxidase activity" EXACT []
synonym: "downregulation of NAD(P)H oxidase activity" EXACT []
synonym: "inhibition of NAD(P)H oxidase activity" NARROW []
is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity
is_a: GO:0051354 ! negative regulation of oxidoreductase activity

[Term]
id: GO:0033862
name: UMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22]
synonym: "ATP:UMP phosphotransferase activity" RELATED [EC:2.7.4.22]
synonym: "PyrH" RELATED [EC:2.7.4.22]
synonym: "SmbA" RELATED [EC:2.7.4.22]
synonym: "UMP-kinase activity" RELATED [EC:2.7.4.22]
synonym: "UMPK" RELATED [EC:2.7.4.22]
synonym: "uridine monophosphate kinase activity" RELATED [EC:2.7.4.22]
xref: EC:2.7.4.22
xref: MetaCyc:2.7.4.22-RXN
xref: RHEA:24400
is_a: GO:0009041 ! UMP/dUMP kinase activity

[Term]
id: GO:0033863
name: ribose 1,5-bisphosphate phosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+." [EC:2.7.4.23, RHEA:20109]
synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" RELATED [EC:2.7.4.23]
synonym: "PhnN" RELATED [EC:2.7.4.23]
synonym: "ribose 1,5-bisphosphokinase activity" RELATED [EC:2.7.4.23]
xref: EC:2.7.4.23
xref: KEGG_REACTION:R06836
xref: MetaCyc:RXN0-1401
xref: RHEA:20109
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033864
name: positive regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of NAD(P)H oxidase activity" NARROW []
synonym: "stimulation of NAD(P)H oxidase activity" NARROW []
synonym: "up regulation of NAD(P)H oxidase activity" EXACT []
synonym: "up-regulation of NAD(P)H oxidase activity" EXACT []
synonym: "upregulation of NAD(P)H oxidase activity" EXACT []
is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity

[Term]
id: GO:0033865
name: nucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "nucleoside bisphosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0033866
name: nucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "nucleoside bisphosphate anabolism" EXACT []
synonym: "nucleoside bisphosphate biosynthesis" EXACT []
synonym: "nucleoside bisphosphate formation" EXACT []
synonym: "nucleoside bisphosphatehate synthesis" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0033867
name: Fas-activated serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8]
synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" RELATED [EC:2.7.11.8]
synonym: "FAST" RELATED [EC:2.7.11.8]
synonym: "FASTK" RELATED [EC:2.7.11.8]
synonym: "STK10" RELATED [EC:2.7.11.8]
xref: EC:2.7.11.8
xref: MetaCyc:2.7.11.8-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0033868
name: obsolete Goodpasture-antigen-binding protein kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [GOC:curators]
comment: This term was made obsolete because it represents a specific gene product.
is_obsolete: true

[Term]
id: GO:0033869
name: nucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "nucleoside bisphosphate breakdown" EXACT []
synonym: "nucleoside bisphosphate catabolism" EXACT []
synonym: "nucleoside bisphosphate degradation" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0033870
name: thiol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16]
synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" RELATED [EC:2.8.2.16]
synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" RELATED [EC:2.8.2.16]
synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16]
xref: EC:2.8.2.16
xref: MetaCyc:THIOL-SULFOTRANSFERASE-RXN
xref: RHEA:14637
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033871
name: heparan sulfate 3-sulfotransferase 2 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. Modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "3-OST-2" RELATED [EC:2.8.2.29]
synonym: "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity" EXACT []
synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" RELATED [EC:2.8.2.29]
synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" RELATED [EC:2.8.2.29]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED []
synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29]
xref: EC:2.8.2.29
xref: MetaCyc:2.8.2.29-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0033872
name: heparan sulfate 3-sulfotransferase 3 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+." [EC:2.8.2.30]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30]
synonym: "3-OST-3" RELATED [EC:2.8.2.30]
synonym: "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity" EXACT []
synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" RELATED [EC:2.8.2.30]
synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" RELATED [EC:2.8.2.30]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" RELATED [EC:2.8.2.30]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" RELATED [EC:2.8.2.30]
synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED []
synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30]
xref: EC:2.8.2.30
xref: MetaCyc:2.8.2.30-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0033873
name: petromyzonol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H+." [EC:2.8.2.31, RHEA:16997]
synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" RELATED [EC:2.8.2.31]
synonym: "PZ-SULT" RELATED [EC:2.8.2.31]
xref: EC:2.8.2.31
xref: KEGG_REACTION:R07797
xref: MetaCyc:2.8.2.31-RXN
xref: RHEA:16997
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033874
name: scymnol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H+." [EC:2.8.2.32, RHEA:15477]
xref: EC:2.8.2.32
xref: KEGG_REACTION:R07798
xref: MetaCyc:2.8.2.32-RXN
xref: RHEA:15477
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033875
name: ribonucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "ribonucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process

[Term]
id: GO:0033876
name: glycochenodeoxycholate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H+." [EC:2.8.2.34, RHEA:17689]
synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" RELATED [EC:2.8.2.34]
synonym: "BAST" RELATED [EC:2.8.2.34]
synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34]
synonym: "bile acid:PAPS:sulfotransferase activity" RELATED [EC:2.8.2.34]
xref: EC:2.8.2.34
xref: KEGG_REACTION:R07289
xref: MetaCyc:2.8.2.34-RXN
xref: RHEA:17689
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033877
name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity
namespace: molecular_function
alt_id: GO:0018728
def: "Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate." [EC:2.8.3.15, RHEA:16469]
synonym: "benzylsuccinate CoA-transferase activity" RELATED [EC:2.8.3.15]
synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" RELATED [EC:2.8.3.15]
synonym: "succinyl-CoA:benzylsuccinate CoA-transferase activity" EXACT []
xref: EC:2.8.3.15
xref: KEGG_REACTION:R05588
xref: MetaCyc:RXN-864
xref: RHEA:16469
xref: UM-BBD_reactionID:r0329
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0033878
name: obsolete hormone-sensitive lipase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [GOC:curators]
comment: This term was obsoleted because it represents a specific gene product that corresponds to diacylglycerol lipase activity ; GO:0120516.
is_obsolete: true
replaced_by: GO:0120516

[Term]
id: GO:0033879
name: acetylajmaline esterase activity
namespace: molecular_function
def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80]
synonym: "17-O-acetylajmaline O-acetylhydrolase activity" RELATED [EC:3.1.1.80]
synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" RELATED [EC:3.1.1.80]
synonym: "AAE" RELATED [EC:3.1.1.80]
synonym: "acetylajmalan esterase activity" RELATED [EC:3.1.1.80]
xref: EC:3.1.1.80
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0033880
name: phenylacetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phenylglyoxylyl-CoA = CoA + H+ + phenylglyoxylate." [EC:3.1.2.25, RHEA:15337]
synonym: "phenylglyoxylyl-CoA hydrolase activity" RELATED [EC:3.1.2.25]
xref: EC:3.1.2.25
xref: KEGG_REACTION:R07294
xref: MetaCyc:3.1.2.25-RXN
xref: RHEA:15337
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0033881
name: bile-acid-CoA transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA." [PMID:22021638, RHEA:49436]
synonym: "bile-acid-CoA hydrolase activity" RELATED []
synonym: "deoxycholoyl-CoA transferase activity" RELATED []
xref: EC:2.8.3.25
xref: KEGG_REACTION:R07295
xref: RHEA:49436
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0033882
name: choloyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27]
synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" RELATED [EC:3.1.2.27]
synonym: "choloyl-coenzyme A thioesterase activity" RELATED [EC:3.1.2.27]
synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27]
synonym: "PTE-2" RELATED [EC:3.1.2.27]
xref: EC:3.1.2.27
xref: MetaCyc:3.1.2.27-RXN
xref: RHEA:14541
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0033883
name: pyridoxal phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74]
synonym: "PLP phosphatase activity" RELATED [EC:3.1.3.74]
synonym: "PNP phosphatase activity" RELATED [EC:3.1.3.74]
synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.74]
synonym: "vitamin B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74]
synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74]
xref: EC:3.1.3.74
xref: MetaCyc:3.1.3.74-RXN
xref: RHEA:20533
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0033884
name: obsolete phosphoethanolamine/phosphocholine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate, and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "phosphoethanolamine/phosphocholine phosphatase activity" EXACT []
is_obsolete: true
consider: GO:0052731
consider: GO:0052732

[Term]
id: GO:0033885
name: 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76, RHEA:16537]
synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity" RELATED [EC:3.1.3.76]
synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.76]
synonym: "dihydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "hydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "hydroxy lipid phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "lipid-phosphate phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "sEH" RELATED [EC:3.1.3.76]
synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76]
xref: EC:3.1.3.76
xref: KEGG_REACTION:R07582
xref: MetaCyc:3.1.3.76-RXN
xref: RHEA:16537
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0033886
name: cellulose-polysulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7]
synonym: "cellulose-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.7]
xref: EC:3.1.6.7
xref: MetaCyc:3.1.6.7-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033887
name: chondro-4-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate." [EC:3.1.6.9, RHEA:11444]
synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" RELATED [EC:3.1.6.9]
xref: EC:3.1.6.9
xref: KEGG_REACTION:R03517
xref: MetaCyc:CHONDRO-4-SULFATASE-RXN
xref: RHEA:11444
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033888
name: chondro-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate." [EC:3.1.6.10, RHEA:10536]
synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" RELATED [EC:3.1.6.10]
xref: EC:3.1.6.10
xref: KEGG_REACTION:R03518
xref: MetaCyc:CHONDRO-6-SULFATASE-RXN
xref: RHEA:10536
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033889
name: N-sulfoglucosamine-3-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15]
synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15]
synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" RELATED [EC:3.1.6.15]
xref: EC:3.1.6.15
xref: MetaCyc:3.1.6.15-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033890
name: ribonuclease D activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5]
synonym: "RNase D activity" RELATED [EC:3.1.13.5]
xref: EC:3.1.13.5
xref: MetaCyc:3.1.13.5-RXN
is_a: GO:0016896 ! RNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033891
name: CC-preferring endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6]
synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" RELATED [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" RELATED [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" RELATED [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" RELATED [EC:3.1.21.6]
xref: EC:3.1.21.6
xref: MetaCyc:3.1.21.6-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033892
name: deoxyribonuclease (pyrimidine dimer) activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1]
synonym: "bacteriophage T4 endodeoxyribonuclease V activity" RELATED [EC:3.1.25.1]
synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" RELATED [EC:3.1.25.1]
synonym: "T4 endonuclease V activity" RELATED [EC:3.1.25.1]
xref: EC:3.1.25.1
xref: MetaCyc:3.1.25.1-RXN
is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base

[Term]
id: GO:0033893
name: ribonuclease IV activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6]
synonym: "endoribonuclease IV activity" RELATED [EC:3.1.26.6]
xref: EC:3.1.26.6
xref: MetaCyc:3.1.26.6-RXN
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033894
name: ribonuclease P4 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7]
xref: EC:3.1.26.7
xref: MetaCyc:3.1.26.7-RXN
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033895
name: ribonuclease [poly-(U)-specific] activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9]
synonym: "ribonuclease (uracil-specific) activity" RELATED [EC:3.1.26.9]
synonym: "uracil-specific endoribonuclease activity" RELATED [EC:3.1.26.9]
synonym: "uracil-specific RNase activity" RELATED [EC:3.1.26.9]
xref: EC:3.1.26.9
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033896
name: ribonuclease IX activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10]
synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" RELATED [EC:3.1.26.10]
xref: EC:3.1.26.10
xref: MetaCyc:3.1.26.10-RXN
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033897
name: ribonuclease T2 activity
namespace: molecular_function
def: "Catalysis of the reaction: a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H+. This reaction is a two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.19, RHEA:68052]
synonym: "acid ribonuclease activity" EXACT []
synonym: "acid RNase activity" EXACT []
synonym: "base-non-specific ribonuclease activity" EXACT []
synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT []
synonym: "Escherichia coli ribonuclease II activity" RELATED [EC:4.6.1.19]
synonym: "non-base specific ribonuclease activity" EXACT []
synonym: "nonbase-specific RNase activity" EXACT []
synonym: "nonspecific RNase activity" EXACT []
synonym: "ribonnuclease (non-base specific) activity" EXACT []
synonym: "ribonuclease (non-base specific) activity" RELATED []
synonym: "ribonuclease II activity" BROAD [EC:4.6.1.19]
synonym: "ribonuclease M activity" EXACT []
synonym: "ribonuclease N2 activity" EXACT []
synonym: "ribonuclease PP3 activity" RELATED []
synonym: "ribonuclease U4 activity" EXACT []
synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT []
synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD []
synonym: "RNAase CL activity" EXACT []
synonym: "RNase (non-base specific) activity" EXACT []
synonym: "RNase II activity" BROAD [EC:4.6.1.19]
synonym: "RNase M activity" RELATED []
synonym: "RNase Ms activity" EXACT []
synonym: "RNase T2 activity" RELATED [EC:4.6.1.19]
xref: EC:4.6.1.19
xref: MetaCyc:3.1.27.5-RXN
xref: RHEA:68052
is_a: GO:0004521 ! RNA endonuclease activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0033898
name: obsolete Bacillus subtilis ribonuclease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides." [GOC:rynl]
comment: The reason for obsoletion is that the term represents a subreaction of GO:0033897 ribonuclease T2 activity.
synonym: "proteus mirabilis RNase activity" EXACT []
synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD []
is_obsolete: true
replaced_by: GO:0033897

[Term]
id: GO:0033899
name: ribonuclease U2 activity
namespace: molecular_function
def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.20]
synonym: "pleospora RNase activity" EXACT []
synonym: "purine specific endoribonuclease activity" EXACT []
synonym: "purine-specific ribonuclease activity" EXACT []
synonym: "purine-specific RNase activity" EXACT []
synonym: "ribonuclease (purine) activity" EXACT []
synonym: "RNase U2 activity" RELATED [EC:4.6.1.20]
synonym: "trichoderma koningi RNase III activity" EXACT []
xref: EC:4.6.1.20
xref: MetaCyc:RXN-19928
is_a: GO:0016892 ! RNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033900
name: ribonuclease F activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7]
synonym: "ribonuclease F (E. coli) activity" RELATED [EC:3.1.27.7]
synonym: "RNase F activity" RELATED [EC:3.1.27.7]
xref: EC:3.1.27.7
xref: MetaCyc:3.1.27.7-RXN
is_a: GO:0016892 ! RNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033901
name: ribonuclease V activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8]
synonym: "endoribonuclease V activity" RELATED [EC:3.1.27.8]
xref: EC:3.1.27.8
xref: MetaCyc:3.1.27.8-RXN
is_a: GO:0016892 ! RNA endonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033902
name: rRNA endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [GOC:curators]
synonym: "alpha-sarcin" RELATED []
xref: EC:4.6.1.23
xref: MetaCyc:3.1.27.10-RXN
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0033903
name: obsolete endo-1,3(4)-beta-glucanase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [GOC:curators]
comment: This term was made obsolete because it was representing two different activities, for which new GO terms have now been created: GO:0052861 glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group and GO:0052862 glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group.
synonym: "endo-1,3(4)-beta-glucanase activity" EXACT []
is_obsolete: true
replaced_by: GO:0052861

[Term]
id: GO:0033904
name: dextranase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11]
synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" RELATED [EC:3.2.1.11]
synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" RELATED [EC:3.2.1.11]
synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" RELATED [EC:3.2.1.11]
synonym: "dextran hydrolase activity" RELATED [EC:3.2.1.11]
synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11]
synonym: "DL 2" RELATED [EC:3.2.1.11]
synonym: "endo-dextranase activity" RELATED [EC:3.2.1.11]
synonym: "endodextranase activity" RELATED [EC:3.2.1.11]
xref: EC:3.2.1.11
xref: MetaCyc:3.2.1.11-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033905
name: xylan endo-1,3-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans." [EC:3.2.1.32]
synonym: "1,3-beta-D-xylan xylanohydrolase activity" RELATED [EC:3.2.1.32]
synonym: "1,3-beta-xylanase activity" RELATED [EC:3.2.1.32]
synonym: "1,3-xylanase activity" RELATED [EC:3.2.1.32]
synonym: "beta-1,3-xylanase activity" RELATED [EC:3.2.1.32]
synonym: "endo-1,3-beta-xylanase activity" RELATED [EC:3.2.1.32]
synonym: "endo-1,3-xylanase activity" RELATED [EC:3.2.1.32]
synonym: "endo-beta-1,3-xylanase activity" RELATED [EC:3.2.1.32]
synonym: "xylanase activity" BROAD [EC:3.2.1.32]
xref: EC:3.2.1.32
xref: MetaCyc:3.2.1.32-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0033906
name: hyaluronoglucuronidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36]
synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" RELATED [EC:3.2.1.36]
synonym: "hyaluronate 3-glycanohydrolase activity" RELATED [EC:3.2.1.36]
synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36]
synonym: "orgelase activity" RELATED [EC:3.2.1.36]
xref: EC:3.2.1.36
xref: MetaCyc:3.2.1.36-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033907
name: beta-D-fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38]
synonym: "beta-D-fucoside fucohydrolase activity" RELATED [EC:3.2.1.38]
synonym: "beta-fucosidase activity" RELATED [EC:3.2.1.38]
xref: EC:3.2.1.38
xref: MetaCyc:3.2.1.38-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033908
name: beta-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43]
synonym: "beta-L-rhamnoside rhamnohydrolase activity" RELATED [EC:3.2.1.43]
xref: EC:3.2.1.43
xref: MetaCyc:3.2.1.43-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033909
name: fucoidanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [PMID:11910806, PMID:6417453]
synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" RELATED [EC:3.2.1.211]
xref: EC:3.2.1.211
xref: MetaCyc:RXN-20949
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033910
name: glucan 1,4-alpha-maltotetraohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60]
synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" RELATED [EC:3.2.1.60]
synonym: "exo-maltotetraohydrolase activity" RELATED [EC:3.2.1.60]
synonym: "G4-amylase activity" RELATED [EC:3.2.1.60]
synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" RELATED [EC:3.2.1.60]
synonym: "maltotetraose-forming amylase activity" RELATED [EC:3.2.1.60]
xref: EC:3.2.1.60
xref: MetaCyc:3.2.1.60-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033911
name: mycodextranase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61]
synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.61]
xref: EC:3.2.1.61
xref: MetaCyc:3.2.1.61-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033912
name: 2,6-beta-fructan 6-levanbiohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64]
synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" RELATED [EC:3.2.1.64]
synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" RELATED [EC:3.2.1.64]
synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" RELATED [EC:3.2.1.64]
synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" RELATED [EC:3.2.1.64]
synonym: "levanbiose-producing levanase activity" RELATED [EC:3.2.1.64]
xref: EC:3.2.1.64
xref: MetaCyc:3.2.1.64-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033913
name: glucan endo-1,2-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans." [EC:3.2.1.71]
synonym: "1,2-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.71]
synonym: "beta-D-1,2-glucanase activity" RELATED [EC:3.2.1.71]
synonym: "endo-(1->2)-beta-D-glucanase activity" RELATED [EC:3.2.1.71]
synonym: "endo-1,2-beta-glucanase activity" RELATED [EC:3.2.1.71]
xref: EC:3.2.1.71
xref: MetaCyc:3.2.1.71-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0033914
name: xylan 1,3-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans." [EC:3.2.1.72]
synonym: "1,3-beta-D-xylan xylohydrolase activity" RELATED [EC:3.2.1.72]
synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" RELATED [EC:3.2.1.72]
synonym: "beta-1,3'-xylanase activity" RELATED [EC:3.2.1.72]
synonym: "exo-1,3-beta-xylosidase activity" RELATED [EC:3.2.1.72]
synonym: "exo-beta-1,3'-xylanase activity" RELATED [EC:3.2.1.72]
xref: EC:3.2.1.72
xref: MetaCyc:3.2.1.72-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0033915
name: mannan 1,2-(1,3)-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose." [EC:3.2.1.77]
synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" RELATED [EC:3.2.1.77]
synonym: "exo-1,2-1,3-alpha-mannosidase activity" RELATED [EC:3.2.1.77]
xref: EC:3.2.1.77
xref: MetaCyc:3.2.1.77-RXN
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0033916
name: beta-agarase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81]
synonym: "AgaA" RELATED [EC:3.2.1.81]
synonym: "AgaB" RELATED [EC:3.2.1.81]
synonym: "agarase activity" BROAD [EC:3.2.1.81]
synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81]
synonym: "agarose 4-glycanohydrolase activity" RELATED [EC:3.2.1.81]
xref: EC:3.2.1.81
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033917
name: exo-poly-alpha-galacturonosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82]
synonym: "exopolygalacturanosidase activity" RELATED [EC:3.2.1.82]
synonym: "exopolygalacturonosidase activity" RELATED [EC:3.2.1.82]
xref: EC:3.2.1.82
xref: MetaCyc:3.2.1.82-RXN
xref: RHEA:56232
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033918
name: kappa-carrageenase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83]
synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" RELATED [EC:3.2.1.83]
synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" RELATED [EC:3.2.1.83]
xref: EC:3.2.1.83
xref: MetaCyc:3.2.1.83-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033919
name: glucan 1,3-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84]
synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" RELATED [EC:3.2.1.84]
synonym: "exo-1,3-alpha-glucanase activity" RELATED [EC:3.2.1.84]
xref: EC:3.2.1.84
xref: MetaCyc:3.2.1.84-RXN
xref: Reactome:R-HSA-532667 "Removal of the second glucose by glucosidase II"
xref: Reactome:R-HSA-548890 "Removal of the third glucose by glucosidase II and release from the chaperone"
xref: Reactome:R-HSA-9683663 "N-glycan trimming of Spike"
xref: Reactome:R-HSA-9694364 "N-glycan glucose trimming of Spike"
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0033920
name: 6-phospho-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [RHEA:24568]
synonym: "6-phospho-beta-D-galactosidase activity" RELATED [EC:3.2.1.85]
synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" RELATED [EC:3.2.1.85]
synonym: "beta-D-phosphogalactoside galactohydrolase activity" RELATED [EC:3.2.1.85]
synonym: "phospho-beta-D-galactosidase activity" RELATED [EC:3.2.1.85]
synonym: "phospho-beta-galactosidase activity" RELATED [EC:3.2.1.85]
xref: EC:3.2.1.85
xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN
xref: RHEA:24568
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033921
name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87]
synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" RELATED [EC:3.2.1.87]
synonym: "capsular polysaccharide galactohydrolase activity" RELATED [EC:3.2.1.87]
synonym: "polysaccharide depolymerase activity" RELATED [EC:3.2.1.87]
xref: EC:3.2.1.87
xref: MetaCyc:3.2.1.87-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033922
name: peptidoglycan beta-N-acetylmuramidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92]
synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" RELATED [EC:3.2.1.92]
synonym: "exo-beta-acetylmuramidase activity" RELATED [EC:3.2.1.92]
synonym: "exo-beta-N-acetylmuramidase activity" RELATED [EC:3.2.1.92]
synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" RELATED [EC:3.2.1.92]
xref: EC:3.2.1.92
xref: MetaCyc:3.2.1.92-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033923
name: glucan 1,6-alpha-isomaltosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94]
synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" RELATED [EC:3.2.1.94]
synonym: "exo-isomaltohydrolase activity" RELATED [EC:3.2.1.94]
synonym: "G2-dextranase activity" RELATED [EC:3.2.1.94]
synonym: "isomalto-dextranase activity" RELATED [EC:3.2.1.94]
synonym: "isomaltodextranase activity" RELATED [EC:3.2.1.94]
xref: EC:3.2.1.94
xref: MetaCyc:3.2.1.94-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033924
name: dextran 1,6-alpha-isomaltotriosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95]
synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" RELATED [EC:3.2.1.95]
synonym: "exo-isomaltotriohydrolase activity" RELATED [EC:3.2.1.95]
xref: EC:3.2.1.95
xref: MetaCyc:3.2.1.95-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033925
name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96]
synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96]
synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96]
synonym: "endo-beta-acetylglucosaminidase activity" RELATED [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase D activity" RELATED [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase F activity" RELATED [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase H activity" RELATED [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase L activity" RELATED [EC:3.2.1.96]
synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" RELATED [EC:3.2.1.96]
synonym: "endo-N-acetyl-beta-glucosaminidase activity" RELATED [EC:3.2.1.96]
synonym: "endoglycosidase H activity" RELATED [EC:3.2.1.96]
synonym: "endoglycosidase S activity" RELATED [EC:3.2.1.96]
synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" RELATED [EC:3.2.1.96]
synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" RELATED [EC:3.2.1.96]
synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" RELATED [EC:3.2.1.96]
synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" RELATED [EC:3.2.1.96]
synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96]
xref: EC:3.2.1.96
xref: MetaCyc:3.2.1.96-RXN
xref: Reactome:R-HSA-8853379 "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033926
name: endo-alpha-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the reactions : D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine and D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-threonyl + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-threonyl." [EC:3.2.1.97]
synonym: "D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine mucinaminohydrolase activity" RELATED [EC:3.2.1.97]
synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" RELATED [EC:3.2.1.97]
synonym: "endo-alpha-acetylgalactosaminidase activity" RELATED [EC:3.2.1.97]
synonym: "mucinaminylserine mucinaminidase activity" EXACT [EC:3.2.1.97]
xref: EC:3.2.1.97
xref: KEGG_REACTION:R04527
xref: MetaCyc:3.2.1.97-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0033927
name: glucan 1,4-alpha-maltohexaosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98]
synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" RELATED [EC:3.2.1.98]
synonym: "exo-maltohexaohydrolase activity" RELATED [EC:3.2.1.98]
synonym: "G6-amylase activity" RELATED [EC:3.2.1.98]
synonym: "maltohexaose-producing amylase activity" RELATED [EC:3.2.1.98]
xref: EC:3.2.1.98
xref: MetaCyc:3.2.1.98-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033928
name: mannan 1,4-mannobiosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100]
synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100]
synonym: "exo-1,4-beta-mannobiohydrolase activity" RELATED [EC:3.2.1.100]
synonym: "exo-beta-mannanase activity" RELATED [EC:3.2.1.100]
synonym: "mannan 1,4-beta-mannobiosidase activity" RELATED [EC:3.2.1.100]
xref: EC:3.2.1.100
xref: MetaCyc:3.2.1.100-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033929
name: blood-group-substance endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102]
synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" RELATED [EC:3.2.1.102]
synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102]
xref: EC:3.2.1.102
xref: MetaCyc:3.2.1.102-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033930
name: keratan-sulfate endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103]
synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103]
synonym: "keratan sulfate endogalactosidase activity" RELATED [EC:3.2.1.103]
synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" RELATED [EC:3.2.1.103]
synonym: "keratanase activity" RELATED [EC:3.2.1.103]
xref: EC:3.2.1.103
xref: MetaCyc:3.2.1.103-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033931
name: endogalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109]
synonym: "galactosaminoglycan glycanohydrolase activity" RELATED [EC:3.2.1.109]
xref: EC:3.2.1.109
xref: MetaCyc:3.2.1.109-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0033932
name: 1,3-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111]
synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" RELATED [EC:3.2.1.111]
synonym: "almond emulsin fucosidase I activity" RELATED [EC:3.2.1.111]
xref: EC:3.2.1.111
xref: MetaCyc:3.2.1.111-RXN
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0033933
name: branched-dextran exo-1,2-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115]
synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" RELATED [EC:3.2.1.115]
synonym: "dextran 1,2-alpha-glucosidase activity" RELATED [EC:3.2.1.115]
synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115]
xref: EC:3.2.1.115
xref: MetaCyc:3.2.1.115-RXN
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0033934
name: glucan 1,4-alpha-maltotriohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116]
synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" RELATED [EC:3.2.1.116]
synonym: "exo-maltotriohydrolase activity" RELATED [EC:3.2.1.116]
synonym: "maltotriohydrolase activity" RELATED [EC:3.2.1.116]
xref: EC:3.2.1.116
xref: MetaCyc:3.2.1.116-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033935
name: oligoxyloglucan beta-glycosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120]
synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" RELATED [EC:3.2.1.120]
synonym: "oligoxyloglucan hydrolase activity" RELATED [EC:3.2.1.120]
synonym: "oligoxyloglucan xyloglucohydrolase activity" RELATED [EC:3.2.1.120]
xref: EC:3.2.1.120
xref: MetaCyc:3.2.1.120-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0033936
name: polymannuronate hydrolase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121]
synonym: "poly(mannuronide) mannuronohydrolase activity" RELATED [EC:3.2.1.121]
synonym: "polymannuronic acid polymerase activity" RELATED [EC:3.2.1.121]
xref: EC:3.2.1.121
xref: MetaCyc:3.2.1.121-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033937
name: 3-deoxy-2-octulosonidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124]
synonym: "2-keto-3-deoxyoctonate hydrolase activity" RELATED [EC:3.2.1.124]
synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" RELATED [EC:3.2.1.124]
synonym: "octulofuranosylono hydrolase activity" RELATED [EC:3.2.1.124]
synonym: "octulopyranosylonohydrolase activity" RELATED [EC:3.2.1.124]
synonym: "octulosylono hydrolase activity" RELATED [EC:3.2.1.124]
xref: EC:3.2.1.124
xref: MetaCyc:3.2.1.124-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033938
name: 1,6-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127]
synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" RELATED [EC:3.2.1.127]
xref: EC:3.2.1.127
xref: MetaCyc:3.2.1.127-RXN
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0033939
name: xylan alpha-1,2-glucuronosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131]
synonym: "1,2-alpha-glucuronidase activity" RELATED [EC:3.2.1.131]
synonym: "alpha-(1->2)-glucuronidase activity" RELATED [EC:3.2.1.131]
synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" RELATED [EC:3.2.1.131]
xref: EC:3.2.1.131
xref: MetaCyc:3.2.1.131-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033940
name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136]
synonym: "endoarabinoxylanase activity" RELATED [EC:3.2.1.136]
synonym: "feraxan endoxylanase activity" RELATED [EC:3.2.1.136]
synonym: "feraxanase activity" RELATED [EC:3.2.1.136]
synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" RELATED [EC:3.2.1.136]
synonym: "glucuronoxylan xylanohydrolase activity" RELATED [EC:3.2.1.136]
synonym: "glucuronoxylan xylohydrolase activity" RELATED [EC:3.2.1.136]
synonym: "glucuronoxylanase activity" RELATED [EC:3.2.1.136]
xref: EC:3.2.1.136
xref: MetaCyc:3.2.1.136-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0033941
name: mannan exo-1,2-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose." [EC:3.2.1.137]
synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" RELATED [EC:3.2.1.137]
synonym: "exo-1,2-1,6-alpha-mannosidase activity" RELATED [EC:3.2.1.137]
xref: EC:3.2.1.137
xref: MetaCyc:3.2.1.137-RXN
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0033942
name: 4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141]
synonym: "4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" RELATED [EC:3.2.1.141]
synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" RELATED [EC:3.2.1.141]
synonym: "malto-oligosyltrehalose trehalohydrolase activity" RELATED [EC:3.2.1.141]
synonym: "maltooligosyl trehalose trehalohydrolase activity" RELATED [EC:3.2.1.141]
xref: EC:3.2.1.141
xref: MetaCyc:3.2.1.141-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033943
name: galactan 1,3-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145]
synonym: "galactan (1,3)-beta-D-galactosidase activity" RELATED [EC:3.2.1.145]
synonym: "galactan (1->3)-beta-D-galactosidase activity" RELATED [EC:3.2.1.145]
xref: EC:3.2.1.145
xref: MetaCyc:3.2.1.145-RXN
is_a: GO:0004565 ! beta-galactosidase activity

[Term]
id: GO:0033944
name: beta-galactofuranosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146]
synonym: "beta-D-galactofuranosidase activity" RELATED [EC:3.2.1.146]
synonym: "beta-D-galactofuranoside hydrolase activity" RELATED [EC:3.2.1.146]
synonym: "exo-beta-D-galactofuranosidase activity" RELATED [EC:3.2.1.146]
synonym: "exo-beta-galactofuranosidase activity" RELATED [EC:3.2.1.146]
xref: EC:3.2.1.146
xref: MetaCyc:3.2.1.146-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033945
name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150]
synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" RELATED [EC:3.2.1.150]
synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" RELATED [EC:3.2.1.150]
xref: EC:3.2.1.150
xref: MetaCyc:3.2.1.150-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033946
name: xyloglucan-specific endo-beta-1,4-glucanase activity
namespace: molecular_function
def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.151]
synonym: "1,4-beta-D-glucan glucanohydrolase activity" BROAD [EC:3.2.1.151]
synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.151]
synonym: "XEG" RELATED [EC:3.2.1.151]
synonym: "XH" RELATED [EC:3.2.1.151]
synonym: "xyloglucan endo-beta-1,4-glucanase activity" RELATED [EC:3.2.1.151]
synonym: "xyloglucanase activity" RELATED [EC:3.2.1.151]
synonym: "xyloglucanendohydrolase activity" RELATED [EC:3.2.1.151]
xref: EC:3.2.1.151
xref: MetaCyc:3.2.1.151-RXN
is_a: GO:0052736 ! beta-glucanase activity

[Term]
id: GO:0033947
name: mannosylglycoprotein endo-beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152]
synonym: "endo-beta-mannosidase activity" RELATED [EC:3.2.1.152]
xref: EC:3.2.1.152
xref: MetaCyc:3.2.1.152-RXN
is_a: GO:0004567 ! beta-mannosidase activity

[Term]
id: GO:0033948
name: fructan beta-(2,1)-fructosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153]
synonym: "1-FEH II" RELATED [EC:3.2.1.153]
synonym: "1-FEH w1" RELATED [EC:3.2.1.153]
synonym: "1-FEH w2" RELATED [EC:3.2.1.153]
synonym: "1-fructan exohydrolase activity" RELATED [EC:3.2.1.153]
synonym: "beta-(2,1)-D-fructan fructohydrolase activity" RELATED [EC:3.2.1.153]
synonym: "beta-(2,1)-fructan exohydrolase activity" RELATED [EC:3.2.1.153]
synonym: "beta-(2,1)-linkage-specific fructan-beta-fructosidase activity" RELATED [EC:3.2.1.153]
xref: EC:3.2.1.153
xref: MetaCyc:3.2.1.153-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033949
name: fructan beta-(2,6)-fructosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154]
synonym: "6-FEH" RELATED [EC:3.2.1.154]
synonym: "beta-(2,6)-D-fructan fructohydrolase activity" RELATED [EC:3.2.1.154]
synonym: "beta-(2,6)-fructan exohydrolase activity" RELATED [EC:3.2.1.154]
xref: EC:3.2.1.154
xref: MetaCyc:3.2.1.154-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033950
name: xyloglucan-specific exo-beta-1,4-glucanase activity
namespace: molecular_function
def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.155]
synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" RELATED [EC:3.2.1.155]
synonym: "Cel74A" RELATED [EC:3.2.1.155]
xref: EC:3.2.1.155
xref: MetaCyc:3.2.1.155-RXN
is_a: GO:0052736 ! beta-glucanase activity

[Term]
id: GO:0033951
name: oligosaccharide reducing-end xylanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156]
synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" RELATED [EC:3.2.1.156]
synonym: "reducing end xylose-releasing exo-oligoxylanase activity" RELATED [EC:3.2.1.156]
synonym: "Rex" RELATED [EC:3.2.1.156]
xref: EC:3.2.1.156
xref: MetaCyc:3.2.1.156-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033952
name: iota-carrageenase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157]
synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" RELATED [EC:3.2.1.157]
xref: EC:3.2.1.157
xref: MetaCyc:3.2.1.157-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033953
name: alpha-agarase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158]
synonym: "agarase A33 activity" NARROW [EC:3.2.1.158]
synonym: "agarase activity" BROAD [EC:3.2.1.158]
synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158]
xref: EC:3.2.1.158
xref: MetaCyc:3.2.1.158-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033954
name: alpha-neoagaro-oligosaccharide hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159]
synonym: "alpha-NAOS hydrolase activity" RELATED [EC:3.2.1.159]
synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" RELATED [EC:3.2.1.159]
synonym: "alpha-neoagarooligosaccharide hydrolase activity" RELATED [EC:3.2.1.159]
xref: EC:3.2.1.159
xref: MetaCyc:3.2.1.159-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033955
name: obsolete mitochondrial DNA inheritance
namespace: biological_process
alt_id: GO:0090142
def: "OBSOLETE. The process in which copies of the mitochondrial genome are distributed into daughter mitochondria upon mitochondrial fission." [GOC:mah]
comment: This term was obsoleted because it represented a phenotype.
synonym: "mitochondrial chromosome segregation" RELATED []
synonym: "mitochondrial DNA segregation" RELATED []
is_obsolete: true
consider: GO:0000002
consider: GO:0000266

[Term]
id: GO:0033956
name: beta-apiosyl-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161]
synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" RELATED [EC:3.2.1.161]
synonym: "furcatin hydrolase activity" RELATED [EC:3.2.1.161]
synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" RELATED [EC:3.2.1.161]
synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" RELATED [EC:3.2.1.161]
xref: EC:3.2.1.161
xref: MetaCyc:RXN-9156
xref: RHEA:21488
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0033957
name: lambda-carrageenase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162]
synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" RELATED [EC:3.2.1.162]
xref: EC:3.2.1.162
xref: MetaCyc:3.2.1.162-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033958
name: DNA-deoxyinosine glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15]
synonym: "deoxyribonucleic acid glycosylase activity" RELATED [EC:3.2.2.15]
synonym: "DNA(hypoxanthine) glycohydrolase activity" RELATED [EC:3.2.2.15]
synonym: "DNA-deoxyinosine deoxyribohydrolase activity" RELATED [EC:3.2.2.15]
synonym: "DNA-deoxyinosine glycosidase activity" RELATED [EC:3.2.2.15]
synonym: "hypoxanthine-DNA glycosylase activity" RELATED [EC:3.2.2.15]
xref: EC:3.2.2.15
xref: MetaCyc:3.2.2.15-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0033959
name: deoxyribodipyrimidine endonucleosidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17]
synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" RELATED [EC:3.2.2.17]
synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" RELATED [EC:3.2.2.17]
synonym: "endonuclease V activity" BROAD [EC:3.2.2.17]
synonym: "PD-DNA glycosylase activity" RELATED [EC:3.2.2.17]
synonym: "pyrimidine dimer DNA glycosylase activity" RELATED [EC:3.2.2.17]
synonym: "pyrimidine dimer DNA-glycosylase activity" RELATED [EC:3.2.2.17]
synonym: "T4-induced UV endonuclease activity" RELATED [EC:3.2.2.17]
xref: EC:3.2.2.17
xref: MetaCyc:3.2.2.17-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0033960
name: N-methyl nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + H+ + ribofuranose." [EC:3.2.2.25, RHEA:10880]
synonym: "7-methylxanthosine nucleosidase activity" RELATED [EC:3.2.2.25]
synonym: "7-methylxanthosine ribohydrolase activity" RELATED [EC:3.2.2.25]
synonym: "methylpurine nucleosidase activity" RELATED [EC:3.2.2.25]
synonym: "N-MeNase activity" RELATED [EC:3.2.2.25]
synonym: "N-methyl nucleoside hydrolase activity" RELATED [EC:3.2.2.25]
xref: EC:3.2.2.25
xref: KEGG_REACTION:R07918
xref: MetaCyc:RXN-7597
xref: RHEA:10880
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0033961
name: cis-stilbene-oxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]
subset: goslim_chembl
synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9]
synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9]
synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "cis-epoxide hydrolase activity" RELATED [EC:3.3.2.9]
synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9]
synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9]
synonym: "mEH" RELATED [EC:3.3.2.9]
synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9]
synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9]
xref: EC:3.3.2.9
xref: MetaCyc:3.3.2.9-RXN
xref: Reactome:R-HSA-5694077 "EPHX1 hydrates BaP4,5O to BaP4,5-DHD"
xref: RHEA:23900
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0033962
name: P-body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]
synonym: "cytoplasmic mRNA processing body assembly" EXACT []
synonym: "P body assembly" EXACT []
synonym: "P body biogenesis" RELATED []
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:0033963
name: cholesterol-5,6-oxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11]
synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" RELATED [EC:3.3.2.11]
synonym: "ChEH" RELATED [EC:3.3.2.11]
synonym: "cholesterol-epoxide hydrolase activity" RELATED [EC:3.3.2.11]
xref: EC:3.3.2.11
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0033964
name: glycosphingolipid deacylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69]
synonym: "glycosphingolipid amidohydrolase activity" RELATED [EC:3.5.1.69]
synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69]
xref: EC:3.5.1.69
xref: MetaCyc:3.5.1.69-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033965
name: aculeacin-A deacylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70]
synonym: "aculeacin A acylase activity" RELATED [EC:3.5.1.70]
synonym: "aculeacin-A amidohydrolase activity" RELATED [EC:3.5.1.70]
xref: EC:3.5.1.70
xref: MetaCyc:3.5.1.70-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033966
name: N-substituted formamide deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91]
synonym: "N-benzylformamide amidohydrolase activity" RELATED [EC:3.5.1.91]
synonym: "NfdA" RELATED [EC:3.5.1.91]
xref: MetaCyc:3.5.1.91-RXN
xref: RHEA:12096
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033967
name: box C/D sno(s)RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving box C/D type small nucleolar RNA." [GOC:krc, GOC:mah]
synonym: "box C/D snoRNA metabolic process" NARROW []
synonym: "box C/D sRNA metabolic process" NARROW []
is_a: GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:0033968
name: glutaryl-7-aminocephalosporanic-acid acylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93]
synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" RELATED [EC:3.5.1.93]
synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" RELATED [EC:3.5.1.93]
synonym: "CA" RELATED [EC:3.5.1.93]
synonym: "cephalosporin acylase activity" RELATED [EC:3.5.1.93]
synonym: "cephalosporin C acylase activity" RELATED [EC:3.5.1.93]
synonym: "GA" RELATED [EC:3.5.1.93]
synonym: "GCA" RELATED [EC:3.5.1.93]
synonym: "GL-7-ACA acylase activity" RELATED [EC:3.5.1.93]
synonym: "glutaryl-7-ACA acylase activity" RELATED [EC:3.5.1.93]
synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" RELATED [EC:3.5.1.93]
xref: EC:3.5.1.93
xref: MetaCyc:3.5.1.93-RXN
xref: RHEA:23508
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033969
name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94, RHEA:19737]
synonym: "4-(glutamylamino)butanoate amidohydrolase activity" RELATED [EC:3.5.1.94]
synonym: "gamma-glutamyl-GABA hydrolase activity" RELATED [EC:3.5.1.94]
synonym: "PuuD" RELATED [EC:3.5.1.94]
synonym: "YcjL" RELATED [EC:3.5.1.94]
xref: EC:3.5.1.94
xref: KEGG_REACTION:R07419
xref: MetaCyc:RXN0-3942
xref: RHEA:19737
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033970
name: N-malonylurea hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = H+ + malonate + urea." [EC:3.5.1.95, RHEA:17361]
synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" RELATED [EC:3.5.1.95]
synonym: "ureidomalonase activity" RELATED [EC:3.5.1.95]
xref: EC:3.5.1.95
xref: KEGG_REACTION:R07629
xref: MetaCyc:3.5.1.95-RXN
xref: RHEA:17361
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033971
name: hydroxyisourate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+." [EC:3.5.2.17, RHEA:23736]
synonym: "5-hydroxyisourate amidohydrolase activity" RELATED [EC:3.5.2.17]
synonym: "5-hydroxyisourate hydrolase activity" RELATED [EC:3.5.2.17]
synonym: "HIUHase activity" RELATED [EC:3.5.2.17]
xref: EC:3.5.2.17
xref: KEGG_REACTION:R06601
xref: MetaCyc:3.5.2.17-RXN
xref: RHEA:23736
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0033972
name: proclavaminate amidinohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea." [EC:3.5.3.22, RHEA:17001]
synonym: "PAH" RELATED [EC:3.5.3.22]
synonym: "proclavaminate amidino hydrolase activity" RELATED [EC:3.5.3.22]
synonym: "proclavaminic acid amidino hydrolase activity" RELATED [EC:3.5.3.22]
xref: EC:3.5.3.22
xref: KEGG_REACTION:R05357
xref: MetaCyc:3.5.3.22-RXN
xref: RHEA:17001
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0033973
name: dCTP deaminase (dUMP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + 2 H2O = diphosphate + dUMP + H+ + NH4." [EC:3.5.4.30, RHEA:19205]
synonym: "dCTP aminohydrolase (dUMP-forming) activity" RELATED [EC:3.5.4.30]
xref: EC:3.5.4.30
xref: KEGG_REACTION:R07307
xref: MetaCyc:3.5.4.30-RXN
xref: RHEA:19205
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0033974
name: nucleoside phosphoacylhydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of mixed phospho-anhydride bonds." [EC:3.6.1.24]
synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" RELATED [EC:3.6.1.24]
xref: EC:3.6.1.24
xref: MetaCyc:3.6.1.24-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0033975
name: (R)-2-haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9]
synonym: "(R)-2-haloacid halidohydrolase activity" RELATED [EC:3.8.1.9]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9]
synonym: "D-2-haloacid dehalogenase activity" RELATED [EC:3.8.1.9]
synonym: "D-DEX" RELATED [EC:3.8.1.9]
xref: EC:3.8.1.9
xref: MetaCyc:RXN-6264
xref: RHEA:22188
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033976
name: 2-haloacid dehalogenase (configuration-inverting) activity
namespace: molecular_function
def: "Catalysis of the reactions: an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H+, and an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H+." [EC:3.8.1.10]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD []
synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" RELATED []
synonym: "DL-2-haloacid dehalogenase activity" BROAD []
synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" RELATED []
synonym: "DL-DEXi" RELATED []
xref: EC:3.8.1.10
xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033977
name: 2-haloacid dehalogenase (configuration-retaining) activity
namespace: molecular_function
def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [RHEA:12072]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD []
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD []
synonym: "DL-2-haloacid dehalogenase activity" BROAD []
synonym: "DL-DEXr" RELATED []
xref: EC:3.8.1.11
xref: MetaCyc:3.8.1.11-RXN
xref: RHEA:12072
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033978
name: phosphonopyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphonopyruvate + H2O = H+ + phosphate + pyruvate." [RHEA:16673]
synonym: "PPH" RELATED [EC:3.11.1.3]
xref: EC:3.11.1.3
xref: KEGG_REACTION:R08200
xref: MetaCyc:3.11.1.3-RXN
xref: RHEA:16673
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0033979
name: box H/ACA sno(s)RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:krc, GOC:mah]
synonym: "box H/ACA snoRNA metabolic process" NARROW []
synonym: "box H/ACA sRNA metabolic process" NARROW []
is_a: GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:0033980
name: phosphonopyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20768]
synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" RELATED [EC:4.1.1.82]
synonym: "3-phosphonopyruvate carboxy-lyase activity" RELATED [EC:4.1.1.82]
xref: EC:4.1.1.82
xref: KEGG_REACTION:R04053
xref: MetaCyc:4.1.1.82-RXN
xref: RHEA:20768
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033981
name: D-dopachrome decarboxylase activity
namespace: molecular_function
alt_id: GO:0030928
def: "Catalysis of the reaction: D-dopachrome + H+ = 5,6-dihydroxyindole + CO2." [EC:4.1.1.84, RHEA:18441]
synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" RELATED [EC:4.1.1.84]
synonym: "D-dopachrome carboxy-lyase activity" RELATED [EC:4.1.1.84]
synonym: "D-dopachrome tautomerase activity" RELATED [EC:4.1.1.84]
synonym: "D-tautomerase activity" RELATED [EC:4.1.1.84]
synonym: "dopachrome conversion activity" BROAD []
synonym: "dopachrome decarboxylase activity" EXACT []
synonym: "phenylpyruvate tautomerase II activity" RELATED [EC:4.1.1.84]
xref: EC:4.1.1.84
xref: KEGG_REACTION:R07313
xref: MetaCyc:4.1.1.84-RXN
xref: RHEA:18441
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033982
name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2." [EC:4.1.1.85, RHEA:14353]
synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" RELATED [EC:4.1.1.85]
synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" RELATED [EC:4.1.1.85]
synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" RELATED [EC:4.1.1.85]
synonym: "KGPDC" RELATED [EC:4.1.1.85]
synonym: "SgaH" RELATED [EC:4.1.1.85]
synonym: "SgbH" RELATED [EC:4.1.1.85]
synonym: "UlaD" RELATED [EC:4.1.1.85]
xref: EC:4.1.1.85
xref: KEGG_REACTION:R07125
xref: MetaCyc:RXN0-705
xref: RHEA:14353
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033983
name: diaminobutyrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutyrate + H+ = 1,3-diaminopropane + CO2." [EC:4.1.1.86, RHEA:15689]
synonym: "DABA DC" RELATED [EC:4.1.1.86]
synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" RELATED [EC:4.1.1.86]
synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" RELATED [EC:4.1.1.86]
synonym: "L-2,4-diaminobutyrate decarboxylase activity" RELATED [EC:4.1.1.86]
xref: EC:4.1.1.86
xref: KEGG_REACTION:R07650
xref: MetaCyc:4.1.1.86-RXN
xref: RHEA:15689
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033984
name: indole-3-glycerol-phosphate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8]
synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" RELATED [EC:4.1.2.8]
synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.8]
synonym: "BX1" RELATED [EC:4.1.2.8]
synonym: "IGL" RELATED [EC:4.1.2.8]
synonym: "indole glycerol phosphate hydrolase activity" RELATED [EC:4.1.2.8]
synonym: "indole synthase activity" RELATED [EC:4.1.2.8]
synonym: "indole-3-glycerol phosphate lyase activity" RELATED [EC:4.1.2.8]
synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.8]
synonym: "indoleglycerolphosphate aldolase activity" RELATED [EC:4.1.2.8]
synonym: "tryptophan synthase alpha activity" NARROW [EC:4.1.2.8]
synonym: "tryptophan synthase alpha subunit activity" NARROW [EC:4.1.2.8]
synonym: "TSA" RELATED [EC:4.1.2.8]
xref: EC:4.1.2.8
xref: KEGG_REACTION:R02340
xref: MetaCyc:RXN0-2381
xref: RHEA:14081
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0033985
name: acidocalcisome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0020022 ! acidocalcisome

[Term]
id: GO:0033986
name: response to methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl]
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0033987
name: 2-hydroxyisoflavanone dehydratase activity
namespace: molecular_function
def: "Catalysis of the reactions: (2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H+ + H2O, and 2-hydroxy-2,3-dihydrogenistein = genistein + H+ + H2O." [EC:4.2.1.105]
synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" RELATED [EC:4.2.1.105]
synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" RELATED [EC:4.2.1.105]
xref: EC:4.2.1.105
xref: MetaCyc:RXN-3284
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033988
name: bile-acid 7alpha-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O." [PMID:26650892, RHEA:10436]
synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" RELATED [EC:4.2.1.106]
synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" RELATED [EC:4.2.1.106]
synonym: "BA7 alpha dehydratase activity" RELATED [EC:4.2.1.106]
xref: EC:4.2.1.106
xref: KEGG_REACTION:R07318
xref: MetaCyc:BA7DEHYDRA-RXN
xref: RHEA:10436
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033989
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107]
synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" RELATED [EC:4.2.1.107]
synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.107]
synonym: "46 kDa hydratase 2 activity" RELATED [EC:4.2.1.107]
synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107]
xref: EC:4.2.1.107
xref: MetaCyc:4.2.1.107-RXN
xref: Reactome:R-HSA-192331 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA"
xref: Reactome:R-HSA-193535 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA"
xref: RHEA:18933
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033990
name: ectoine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H2O." [EC:4.2.1.108, RHEA:17281]
synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" RELATED [EC:4.2.1.108]
synonym: "EctC" RELATED [EC:4.2.1.108]
synonym: "L-ectoine synthase activity" RELATED [EC:4.2.1.108]
synonym: "N-acetyldiaminobutanoate dehydratase activity" RELATED [EC:4.2.1.108]
synonym: "N-acetyldiaminobutyrate dehydratase activity" RELATED [EC:4.2.1.108]
synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" RELATED [EC:4.2.1.108]
xref: EC:4.2.1.108
xref: KEGG_REACTION:R06979
xref: MetaCyc:R103-RXN
xref: RHEA:17281
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033991
name: aldos-2-ulose dehydratase activity
namespace: molecular_function
def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110]
synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" RELATED [EC:4.2.1.110]
synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" RELATED [EC:4.2.1.110]
synonym: "AUDH" RELATED [EC:4.2.1.110]
synonym: "pyranosone dehydratase activity" RELATED [EC:4.2.1.110]
xref: EC:4.2.1.110
xref: MetaCyc:RXN-14306
xref: RHEA:12100
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033992
name: 1,5-anhydro-D-fructose dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111]
synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" RELATED [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" RELATED [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" RELATED [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydro-lyase activity" RELATED [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydrolyase activity" RELATED [EC:4.2.1.111]
synonym: "AF dehydratase activity" RELATED [EC:4.2.1.111]
synonym: "AFDH" RELATED [EC:4.2.1.111]
xref: EC:4.2.1.111
xref: MetaCyc:4.2.1.111-RXN
xref: RHEA:15725
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033993
name: response to lipid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0033994
name: glucuronan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14]
synonym: "(1,4)-beta-D-glucuronan lyase activity" RELATED [EC:4.2.2.14]
xref: EC:4.2.2.14
xref: MetaCyc:4.2.2.14-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033995
name: anhydrosialidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15]
synonym: "anhydroneuraminidase activity" RELATED [EC:4.2.2.15]
synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" RELATED [EC:4.2.2.15]
synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" RELATED [EC:4.2.2.15]
synonym: "sialidase L activity" RELATED [EC:4.2.2.15]
xref: EC:4.2.2.15
xref: MetaCyc:4.2.2.15-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033996
name: levan fructotransferase (DFA-IV-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16]
synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" RELATED [EC:4.2.2.16]
synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" RELATED [EC:4.2.2.16]
synonym: "levan fructotransferase activity" RELATED [EC:4.2.2.16]
xref: EC:4.2.2.16
xref: MetaCyc:4.2.2.16-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033997
name: inulin fructotransferase (DFA-I-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17]
synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" RELATED [EC:4.2.2.17]
synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" RELATED [EC:4.2.2.17]
synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" RELATED [EC:4.2.2.17]
synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" RELATED [EC:4.2.2.17]
synonym: "inulin fructotransferase (DFA-I-producing) activity" RELATED [EC:4.2.2.17]
xref: EC:4.2.2.17
xref: MetaCyc:4.2.2.17-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033998
name: inulin fructotransferase (DFA-III-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18]
synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" RELATED [EC:4.2.2.18]
synonym: "inulase II activity" RELATED [EC:4.2.2.18]
synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" RELATED [EC:4.2.2.18]
synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" RELATED [EC:4.2.2.18]
synonym: "inulin fructotransferase (depolymerizing) activity" RELATED [EC:4.2.2.18]
synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" RELATED [EC:4.2.2.18]
synonym: "inulin fructotransferase (DFA-III-producing) activity" RELATED [EC:4.2.2.18]
synonym: "inulinase II activity" RELATED [EC:4.2.2.18]
xref: EC:4.2.2.18
xref: MetaCyc:4.2.2.18-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033999
name: chondroitin B lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate." [EC:4.2.2.19]
synonym: "ChnB" RELATED [EC:4.2.2.19]
synonym: "chonB" RELATED [EC:4.2.2.19]
synonym: "chondroitinase B activity" RELATED [EC:4.2.2.19]
synonym: "dermatan sulfate lyase activity" EXACT []
xref: EC:4.2.2.19
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0034000
name: chondroitin-sulfate-ABC endolyase activity
namespace: molecular_function
def: "Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20]
synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC endoeliminase activity" RELATED [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC endolyase activity" RELATED [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20]
synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20]
synonym: "chondroitinase activity" BROAD [EC:4.2.2.20]
synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20]
synonym: "ChS ABC lyase I activity" RELATED [EC:4.2.2.20]
xref: EC:4.2.2.20
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0034001
name: chondroitin-sulfate-ABC exolyase activity
namespace: molecular_function
def: "Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21]
synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC exoeliminase activity" RELATED [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC exolyase activity" RELATED [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21]
synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21]
synonym: "chondroitinase activity" BROAD [EC:4.2.2.21]
synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21]
synonym: "ChS ABC lyase II activity" RELATED [EC:4.2.2.21]
xref: EC:4.2.2.21
xref: MetaCyc:4.2.2.21-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0034002
name: (R)-limonene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate." [EC:4.2.3.20, RHEA:10940]
synonym: "(+)-limonene synthase activity" RELATED [EC:4.2.3.20]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" RELATED [EC:4.2.3.20]
synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" RELATED [EC:4.2.3.20]
xref: EC:4.2.3.20
xref: KEGG_REACTION:R06120
xref: MetaCyc:4.2.3.20-RXN
xref: RHEA:10940
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0034003
name: vetispiradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene." [EC:4.2.3.21, RHEA:10340]
synonym: "HVS" RELATED [EC:4.2.3.21]
synonym: "pemnaspirodiene synthase activity" RELATED [EC:4.2.3.21]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" RELATED [EC:4.2.3.21]
synonym: "vetispiradiene cyclase activity" RELATED [EC:4.2.3.21]
synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" RELATED [EC:4.2.3.21]
xref: EC:4.2.3.21
xref: KEGG_REACTION:R06523
xref: MetaCyc:RXN-4823
xref: RHEA:10340
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0034004
name: germacradienol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate." [EC:4.2.3.22]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" RELATED [EC:4.2.3.22]
xref: EC:4.2.3.22
xref: RHEA:22436
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034005
name: germacrene-A synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23, RHEA:12516]
synonym: "(+)-(10R)-germacrene A synthase activity" RELATED [EC:4.2.3.23]
synonym: "(+)-germacrene A synthase activity" RELATED [EC:4.2.3.23]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" RELATED [EC:4.2.3.23]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" RELATED [EC:4.2.3.23]
synonym: "GAS" RELATED [EC:4.2.3.23]
synonym: "germacrene A synthase activity" RELATED [EC:4.2.3.23]
xref: EC:4.2.3.23
xref: KEGG_REACTION:R07649
xref: MetaCyc:RXN-11527
xref: RHEA:12516
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0034006
name: amorpha-4,11-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24, RHEA:18325]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" RELATED [EC:4.2.3.24]
synonym: "amorphadiene synthase activity" RELATED [EC:4.2.3.24]
xref: EC:4.2.3.24
xref: KEGG_REACTION:R07630
xref: MetaCyc:RXN-8046
xref: RHEA:18325
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0034007
name: S-linalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H2O = (S)-linalool + diphosphate." [EC:4.2.3.25, RHEA:24116]
synonym: "3S-linalool synthase activity" RELATED [EC:4.2.3.25]
synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" RELATED [EC:4.2.3.25]
synonym: "LIS" RELATED [EC:4.2.3.25]
xref: EC:4.2.3.25
xref: KEGG_REACTION:R07631
xref: MetaCyc:4.2.3.25-RXN
xref: RHEA:24116
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034008
name: R-linalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H2O = (R)-linalool + diphosphate." [EC:4.2.3.26, RHEA:15809]
synonym: "(-)-3R-linalool synthase activity" RELATED [EC:4.2.3.26]
synonym: "(3R)-linalool synthase activity" RELATED [EC:4.2.3.26]
synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" RELATED [EC:4.2.3.26]
xref: EC:4.2.3.26
xref: KEGG_REACTION:R07632
xref: MetaCyc:4.2.3.26-RXN
xref: RHEA:15809
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034009
name: isoprene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene." [RHEA:13369]
synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" RELATED [EC:4.2.3.27]
synonym: "ISPC" RELATED [EC:4.2.3.27]
synonym: "ISPS" RELATED [EC:4.2.3.27]
xref: EC:4.2.3.27
xref: KEGG_REACTION:R08199
xref: MetaCyc:4.2.3.27-RXN
xref: RHEA:13369
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0034010
name: sulfolactate sulfo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite." [EC:4.4.1.24, RHEA:21428]
synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" RELATED [EC:4.4.1.24]
synonym: "3-sulfolactate bisulfite-lyase activity" RELATED [EC:4.4.1.24]
synonym: "Suy" RELATED [EC:4.4.1.24]
synonym: "SuyAB" RELATED [EC:4.4.1.24]
xref: EC:4.4.1.24
xref: KEGG_REACTION:R07633
xref: MetaCyc:RXN-11691
xref: RHEA:21428
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034011
name: L-cysteate sulfo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteate + H2O = NH4 + pyruvate + sulfite." [EC:4.4.1.25, RHEA:13441]
synonym: "CuyA" RELATED [EC:4.4.1.25]
synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" RELATED [EC:4.4.1.25]
synonym: "L-cysteate sulfo-lyase (deaminating) activity" RELATED [EC:4.4.1.25]
xref: EC:4.4.1.25
xref: KEGG_REACTION:R07634
xref: MetaCyc:4.4.1.25-RXN
xref: RHEA:13441
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034012
name: FAD-AMP lyase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: FAD = AMP + H+ + riboflavin cyclic-4',5'-phosphate." [RHEA:13729]
synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" RELATED [EC:4.6.1.15]
synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" RELATED [EC:4.6.1.15]
synonym: "FMN cyclase activity" RELATED [EC:4.6.1.15]
xref: EC:4.6.1.15
xref: RHEA:13729
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0034013
name: aliphatic aldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [RHEA:11316]
synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.8.1.2]
xref: EC:4.8.1.2
xref: MetaCyc:4.99.1.5-RXN
xref: RHEA:11316
is_a: GO:0141122 ! nitrogen-oxygen hydrolyase activity

[Term]
id: GO:0034014
name: response to triglyceride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:sl]
synonym: "response to triacylglyceride" EXACT []
synonym: "response to triacylglycerol" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034015
name: L-ribulose-5-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22, RHEA:18497]
synonym: "L-xylulose 5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.22]
synonym: "SgaU" RELATED [EC:5.1.3.22]
synonym: "UlaE" RELATED [EC:5.1.3.22]
xref: EC:5.1.3.22
xref: MetaCyc:LXULRU5P-RXN
xref: RHEA:18497
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0034016
name: polyenoic fatty acid isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate." [RHEA:14889]
synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" RELATED [EC:5.3.3.13]
synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" RELATED [EC:5.3.3.13]
synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" RELATED [EC:5.3.3.13]
synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" RELATED [EC:5.3.3.13]
synonym: "PFI" RELATED [EC:5.3.3.13]
xref: EC:5.3.3.13
xref: KEGG_REACTION:R06502
xref: MetaCyc:5.3.3.13-RXN
xref: RHEA:14889
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034017
name: trans-2-decenoyl-acyl-carrier-protein isomerase activity
namespace: molecular_function
alt_id: GO:0043832
def: "Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]." [RHEA:23568]
synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14]
synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" RELATED [EC:5.3.3.14]
synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT []
synonym: "trans-2, cis-3 decenoyl-ACP isomerase activity" EXACT []
synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" RELATED [EC:5.3.3.14]
synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" RELATED [EC:5.3.3.14]
synonym: "trans-2-decenoyl-ACP isomerase activity" RELATED [EC:5.3.3.14]
xref: EC:5.3.3.14
xref: MetaCyc:5.3.3.14-RXN
xref: RHEA:23568
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034018
name: ascopyrone tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.2.7]
synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" RELATED [EC:5.3.2.7]
synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" RELATED [EC:5.3.2.7]
synonym: "APM tautomerase activity" RELATED [EC:5.3.2.7]
synonym: "APTM" RELATED [EC:5.3.2.7]
synonym: "ascopyrone intramolecular oxidoreductase activity" RELATED [EC:5.3.2.7]
synonym: "ascopyrone isomerase activity" RELATED [EC:5.3.2.7]
synonym: "ascopyrone P tautomerase activity" RELATED [EC:5.3.2.7]
xref: EC:5.3.2.7
xref: MetaCyc:5.3.3.15-RXN
xref: RHEA:22568
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0034019
name: obsolete capsanthin/capsorubin synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: violaxanthin = capsorubin, and antheraxanthin = capsanthin." [GOC:curators]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "capsanthin/capsorubin synthase activity" EXACT []
is_obsolete: true
consider: GO:0052727
consider: GO:0052728

[Term]
id: GO:0034020
name: neoxanthin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin." [EC:5.3.99.9, RHEA:10128]
synonym: "NSY" RELATED [EC:5.3.99.9]
synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" RELATED [EC:5.3.99.9]
xref: EC:5.3.99.9
xref: KEGG_REACTION:R06948
xref: MetaCyc:RXN1F-155
xref: RHEA:10128
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034021
name: response to silicon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:sl]
synonym: "response to silica" EXACT []
synonym: "response to silox" EXACT []
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034022
name: 3-(hydroxyamino)phenol mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3, RHEA:20577]
synonym: "3-(hydroxyamino)phenol hydroxymutase activity" RELATED [EC:5.4.4.3]
synonym: "3-hydroxylaminophenol mutase activity" RELATED [EC:5.4.4.3]
synonym: "3HAP mutase activity" RELATED [EC:5.4.4.3]
xref: EC:5.4.4.3
xref: KEGG_REACTION:R06988
xref: MetaCyc:5.4.4.3-RXN
xref: RHEA:20577
xref: UM-BBD_enzymeID:r1496
is_a: GO:0050486 ! intramolecular hydroxytransferase activity

[Term]
id: GO:0034023
name: 5-(carboxyamino)imidazole ribonucleotide mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18]
synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" RELATED [EC:5.4.99.18]
synonym: "class I PurE" RELATED [EC:5.4.99.18]
synonym: "N5-CAIR mutase activity" RELATED [EC:5.4.99.18]
synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" RELATED [EC:5.4.99.18]
synonym: "PurE" RELATED [EC:5.4.99.18]
xref: EC:5.4.99.18
xref: MetaCyc:RXN0-743
xref: RHEA:13193
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034024
name: glutamate-putrescine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H+ + phosphate." [EC:6.3.1.11, RHEA:13633]
synonym: "gamma-glutamylputrescine synthetase activity" RELATED [EC:6.3.1.11]
synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" RELATED [EC:6.3.1.11]
synonym: "YcjK" RELATED [EC:6.3.1.11]
xref: EC:6.3.1.11
xref: KEGG_REACTION:R07414
xref: MetaCyc:RXN0-3901
xref: RHEA:13633
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0034025
name: D-aspartate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12]
synonym: "aslfm" RELATED [EC:6.3.1.12]
synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" RELATED [EC:6.3.1.12]
synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12]
synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" RELATED [EC:6.3.1.12]
xref: EC:6.3.1.12
xref: MetaCyc:6.3.1.12-RXN
xref: RHEA:10752
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0034026
name: L-amino-acid alpha-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.49]
synonym: "bacilysin synthetase activity" EXACT []
synonym: "L-amino acid alpha-ligase activity" EXACT []
synonym: "L-amino acid ligase activity" EXACT []
synonym: "YwfE" RELATED []
xref: EC:6.3.2.49
xref: MetaCyc:RXN-16296
xref: RHEA:44332
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0034027
name: (carboxyethyl)arginine beta-lactam-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H+." [EC:6.3.3.4, RHEA:23620]
synonym: "beta-lactam synthetase activity" RELATED [EC:6.3.3.4]
synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" RELATED [EC:6.3.3.4]
synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" RELATED [EC:6.3.3.4]
xref: EC:6.3.3.4
xref: KEGG_REACTION:R05467
xref: MetaCyc:6.3.3.4-RXN
xref: RHEA:23620
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0034028
name: 5-(carboxyamino)imidazole ribonucleotide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate." [EC:6.3.4.18, RHEA:19317]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" RELATED [EC:6.3.4.18]
synonym: "N5-CAIR synthetase activity" RELATED [EC:6.3.4.18]
synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.4.18]
synonym: "PurK" RELATED [EC:6.3.4.18]
xref: EC:6.3.4.18
xref: KEGG_REACTION:R07404
xref: MetaCyc:RXN0-742
xref: RHEA:19317
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0034029
name: 2-oxoglutarate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H+ + oxalosuccinate + phosphate." [EC:6.4.1.7, RHEA:20425]
synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7]
synonym: "CFI" RELATED [EC:6.4.1.7]
synonym: "OGC" RELATED [EC:6.4.1.7]
synonym: "oxalosuccinate synthetase activity" RELATED [EC:6.4.1.7]
xref: EC:6.4.1.7
xref: KEGG_REACTION:R08201
xref: MetaCyc:RXN-8457
xref: RHEA:20425
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0034030
name: ribonucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "ribonucleoside bisphosphate anabolism" EXACT []
synonym: "ribonucleoside bisphosphate biosynthesis" EXACT []
synonym: "ribonucleoside bisphosphate formation" EXACT []
synonym: "ribonucleoside bisphosphate synthesis" EXACT []
is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034031
name: ribonucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "ribonucleoside bisphosphate breakdown" EXACT []
synonym: "ribonucleoside bisphosphate catabolism" EXACT []
synonym: "ribonucleoside bisphosphate degradation" EXACT []
is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034032
name: purine nucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "purine nucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0034033
name: purine nucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "purine nucleoside bisphosphate anabolism" EXACT []
synonym: "purine nucleoside bisphosphate biosynthesis" EXACT []
synonym: "purine nucleoside bisphosphate formation" EXACT []
synonym: "purine nucleoside bisphosphate synthesis" EXACT []
is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0034034
name: purine nucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "purine nucleoside bisphosphate breakdown" EXACT []
synonym: "purine nucleoside bisphosphate catabolism" EXACT []
synonym: "purine nucleoside bisphosphate degradation" EXACT []
is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0034035
name: purine ribonucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "purine ribonucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process

[Term]
id: GO:0034036
name: purine ribonucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "purine ribonucleoside bisphosphate anabolism" EXACT []
synonym: "purine ribonucleoside bisphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside bisphosphate formation" EXACT []
synonym: "purine ribonucleoside bisphosphate synthesis" EXACT []
is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034037
name: purine ribonucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
synonym: "purine ribonucleoside bisphosphate breakdown" EXACT []
synonym: "purine ribonucleoside bisphosphate catabolism" EXACT []
synonym: "purine ribonucleoside bisphosphate degradation" EXACT []
is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034038
name: deoxyhypusine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [GOC:pde, RHEA:33299]
comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'.
synonym: "(4-aminobutyl)lysine synthase" BROAD [EC:2.5.1.46]
synonym: "eIF-5A-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46]
synonym: "spermidine dehydrogenase" BROAD [EC:2.5.1.46]
xref: EC:2.5.1.46
xref: MetaCyc:2.5.1.46-RXN
xref: Reactome:R-HSA-204617 "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A"
xref: Reactome:R-HSA-204647 "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine"
xref: RHEA:33299
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0034039
name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "8-oxoG DNA N-glycosylase activity" EXACT []
is_a: GO:0008534 ! oxidized purine nucleobase lesion DNA N-glycosylase activity

[Term]
id: GO:0034040
name: ATPase-coupled lipid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:BHF, GOC:rl]
synonym: "ATP-dependent lipid transmembrane transporter activity" EXACT []
synonym: "lipid-transporting ATPase activity" BROAD []
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:0034041
name: ABC-type sterol transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:BHF, GOC:rl]
synonym: "ATP-coupled sterol transmembrane transporter activity" RELATED []
synonym: "ATP-dependent sterol transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled sterol transmembrane transporter activity" RELATED []
synonym: "sterol-transporting ATPase activity" RELATED []
xref: Reactome:R-HSA-265783 "ABCG5:ABCG8 transports sterols from cytosol to extracellular region"
xref: Reactome:R-HSA-5679101 "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region"
xref: Reactome:R-HSA-5679145 "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region"
is_a: GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0034042
name: 5-formyluracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "5-foU DNA N-glycosylase activity" EXACT []
is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

[Term]
id: GO:0034043
name: 5-hydroxymethyluracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "5-hmU DNA N-glycosylase activity" EXACT []
is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

[Term]
id: GO:0034044
name: exomer complex
namespace: cellular_component
def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0034045
name: phagophore assembly site membrane
namespace: cellular_component
def: "A cellular membrane associated with the phagophore assembly site." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324]
synonym: "isolation membrane" RELATED []
synonym: "PAS membrane" EXACT []
synonym: "phagophore" RELATED [PMID:20811355]
synonym: "pre-autophagosomal structure membrane" NARROW []
is_a: GO:0016020 ! membrane
relationship: part_of GO:0000407 ! phagophore assembly site

[Term]
id: GO:0034046
name: poly(G) binding
namespace: molecular_function
def: "Binding to a sequence of guanine residues in an RNA molecule." [GOC:mah]
synonym: "poly(G) binding, within an RNA molecule" EXACT []
synonym: "poly(rG) binding" EXACT [GOC:mah]
is_a: GO:0070717 ! poly-purine tract binding

[Term]
id: GO:0034050
name: symbiont-induced defense-related programmed cell death
namespace: biological_process
def: "Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules." [GOC:pamgo_curators]
comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'symbiont-mediated activation of host programmed cell death' ; GO:0052042'.
synonym: "host programmed cell death induced by symbiont" EXACT []
synonym: "programmed cell death induced by symbiont" EXACT []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0034051
name: negative regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators]
synonym: "down regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "down-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "downregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "inhibition of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "negative regulation of HR" EXACT [GOC:pamgo_curators]
synonym: "negative regulation of HR-PCD" EXACT [GOC:pamgo_curators]
synonym: "negative regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators]
is_a: GO:0010363 ! regulation of plant-type hypersensitive response
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0045824 ! negative regulation of innate immune response
relationship: negatively_regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0034052
name: positive regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators]
synonym: "activation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "positive regulation of HR" EXACT [GOC:pamgo_curators]
synonym: "positive regulation of HR-PCD" RELATED [GOC:pamgo_curators]
synonym: "positive regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "stimulation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "up regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "up-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "upregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
is_a: GO:0010363 ! regulation of plant-type hypersensitive response
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0045089 ! positive regulation of innate immune response
relationship: positively_regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0034053
name: obsolete symbiont-mediated perturbation of host defense-related programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process in which a symbiont modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents the same process as symbiont-mediated perturbation of host programmed cell death ; GO:0052040.
synonym: "modulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "modulation by symbiont of host defense-related programmed cell death" EXACT []
synonym: "modulation by symbiont of host HR" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of host hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
is_obsolete: true
replaced_by: GO:0052040

[Term]
id: GO:0034054
name: obsolete symbiont-mediated suppression of host defense-related programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host programmed cell death ; GO:0052041.
synonym: "down regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "down-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "downregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "inhibition by symbiont of host defense-related PCD" NARROW [GOC:pamgo_curators]
synonym: "inhibition by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "inhibition of host defense-related PCD" NARROW [GOC:pamgo_curators]
synonym: "inhibition of HR" NARROW [GOC:pamgo_curators]
synonym: "inhibition of hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of host defense-related programmed cell death" EXACT []
synonym: "negative regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "suppression by symbiont of host defense-related programmed cell death" EXACT []
synonym: "suppression of HR" NARROW [GOC:pamgo_curators]
is_obsolete: true
replaced_by: GO:0052041

[Term]
id: GO:0034055
name: effector-mediated activation of host programmed cell death by symbiont
namespace: biological_process
def: "A symbiont process in which a molecule secreted by the symbiont activates a programmed cell death pathway in the host to suppress the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "effector-mediated activation of programmed cell death in host" EXACT []
synonym: "effector-mediated induction of programmed cell death in host" EXACT []
synonym: "enhancement by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of host defense-related programmed cell death" RELATED []
synonym: "stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
is_a: GO:0052042 ! symbiont-mediated activation of host programmed cell death
is_a: GO:0140403 ! effector-mediated suppression of host innate immune response

[Term]
id: GO:0034056
name: estrogen response element binding
namespace: molecular_function
def: "Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005]
synonym: "ERE binding" EXACT []
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0034057
name: RNA strand-exchange activity
namespace: molecular_function
def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100]
is_a: GO:0003725 ! double-stranded RNA binding
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0034058
name: endosomal vesicle fusion
namespace: biological_process
def: "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]
synonym: "endosome vesicle fusion" EXACT []
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:0034059
name: response to anoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv]
comment: Note that this term should not be confused with 'response to hypoxia ; GO:0001666'.
synonym: "response to anoxic stress" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0036293 ! response to decreased oxygen levels

[Term]
id: GO:0034060
name: cyanelle stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0034061
name: DNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)." [RHEA:22508]
xref: RHEA:22508
is_a: GO:0016779 ! nucleotidyltransferase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0034062
name: 5'-3' RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end." [GOC:mah, GOC:pf, RHEA:21248]
synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6]
synonym: "C RNA formation factors" RELATED [EC:2.7.7.6]
synonym: "ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.6]
synonym: "ribonucleate polymerase activity" RELATED [EC:2.7.7.6]
synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6]
synonym: "ribonucleic acid polymerase activity" RELATED [EC:2.7.7.6]
synonym: "ribonucleic acid transcriptase activity" RELATED [EC:2.7.7.6]
synonym: "ribonucleic polymerase activity" RELATED [EC:2.7.7.6]
synonym: "ribonucleic transcriptase activity" RELATED [EC:2.7.7.6]
synonym: "RNA nucleotidyltransferase activity" RELATED [EC:2.7.7.6]
synonym: "RNA polymerase activity" BROAD []
synonym: "RNA transcriptase activity" RELATED [EC:2.7.7.6]
synonym: "transcriptase" BROAD [EC:2.7.7.6]
xref: Reactome:R-HSA-5696807 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA"
xref: Reactome:R-HSA-6786881 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA"
xref: RHEA:21248
is_a: GO:0097747 ! RNA polymerase activity

[Term]
id: GO:0034063
name: stress granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]
synonym: "SG assembly" EXACT [PMID:19825938]
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:0034064
name: Tor2-Mei2-Ste11 complex
namespace: cellular_component
def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0034066
name: Ric1-Rgp1 guanyl-nucleotide exchange factor complex
namespace: cellular_component
def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452]
synonym: "Ric1p-Rgp1p complex" RELATED []
is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0034067
name: protein localization to Golgi apparatus
namespace: biological_process
alt_id: GO:0000042
alt_id: GO:0072600
def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]
synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah]
synonym: "establishment of protein localization in Golgi" NARROW []
synonym: "establishment of protein localization to Golgi" NARROW []
synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah]
synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah]
synonym: "protein localization in Golgi apparatus" EXACT []
synonym: "protein targeting to Golgi" RELATED []
synonym: "protein-Golgi targeting" RELATED []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0034068
name: aminoglycoside nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb]
synonym: "aminoglycoside adenylyltransferase activity" NARROW []
synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0034069
name: aminoglycoside N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb]
synonym: "kanamycin acetyltransferase activity" NARROW []
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0034070
name: aminoglycoside 1-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb]
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0034071
name: aminoglycoside phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah]
synonym: "aminoglycoside kinase activity" EXACT []
xref: EC:2.7.1.190
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0034072
name: squalene cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0034073
name: tetrahymanol cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = tetrahymanol." [GOC:cb, PMID:18033581]
is_a: GO:0034072 ! squalene cyclase activity

[Term]
id: GO:0034074
name: marneral synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, PMID:16425307, PMID:18033581]
xref: MetaCyc:RXN-9664
xref: RHEA:31875
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034075
name: arabidiol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751]
xref: EC:4.2.1.124
xref: MetaCyc:RXN-9684
xref: RHEA:31035
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034076
name: cucurbitadienol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, PMID:18033581]
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034077
name: butanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123]
synonym: "butanediol metabolism" EXACT []
synonym: "butylene glycol metabolic process" EXACT []
synonym: "butylene glycol metabolism" EXACT []
is_a: GO:0042844 ! glycol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0034078
name: butanediol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123]
synonym: "butanediol breakdown" EXACT []
synonym: "butanediol catabolism" EXACT []
synonym: "butanediol degradation" EXACT []
synonym: "butanediol utilization" RELATED []
synonym: "butylene glycol catabolic process" EXACT []
synonym: "butylene glycol catabolism" EXACT []
is_a: GO:0034077 ! butanediol metabolic process
is_a: GO:0042846 ! glycol catabolic process

[Term]
id: GO:0034079
name: butanediol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:P125-PWY]
synonym: "butanediol anabolism" EXACT []
synonym: "butanediol biosynthesis" EXACT []
synonym: "butanediol formation" EXACT []
synonym: "butanediol synthesis" EXACT []
synonym: "butylene glycol biosynthesis" EXACT []
synonym: "butylene glycol biosynthetic process" EXACT []
xref: MetaCyc:P125-PWY
is_a: GO:0034077 ! butanediol metabolic process
is_a: GO:0042845 ! glycol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0034080
name: CENP-A containing chromatin assembly
namespace: biological_process
alt_id: GO:0034509
alt_id: GO:0061641
def: "The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]
synonym: "CenH3-containing nucleosome assembly at centromere" RELATED []
synonym: "CENP-A containing chromatin organization" RELATED []
synonym: "CENP-A containing nucleosome assembly" RELATED []
synonym: "CENP-A containing nucleosome assembly at centromere" EXACT [GOC:vw]
synonym: "CENP-A deposition" RELATED [GOC:vw]
synonym: "CENP-A loading" RELATED [GOC:vw]
synonym: "centromere specific nucleosome exchange" RELATED [GOC:mah]
synonym: "centromere-specific histone exchange" EXACT [GOC:mah, GOC:vw]
synonym: "centromeric chromatin organization" RELATED [GOC:dph]
synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:mah]
synonym: "DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:mah]
is_a: GO:0031055 ! chromatin remodeling at centromere
relationship: part_of GO:0034508 ! centromere complex assembly

[Term]
id: GO:0034081
name: polyketide synthase complex
namespace: cellular_component
def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085]
synonym: "PKS" RELATED []
synonym: "PKS complex" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034082
name: type II polyketide synthase complex
namespace: cellular_component
def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085]
synonym: "type II PKS" EXACT []
synonym: "type II PKS complex" EXACT []
synonym: "type II polyketide synthase" EXACT []
is_a: GO:0034081 ! polyketide synthase complex

[Term]
id: GO:0034083
name: type III polyketide synthase complex
namespace: cellular_component
def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085]
synonym: "type III PKS" EXACT []
synonym: "type III PKS complex" EXACT []
synonym: "type III polyketide synthase" EXACT []
is_a: GO:0034081 ! polyketide synthase complex

[Term]
id: GO:0034084
name: steryl deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159]
synonym: "sterol deacetylase activity" EXACT []
synonym: "steryl acetyl hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0034085
name: establishment of sister chromatid cohesion
namespace: biological_process
def: "The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase." [GOC:jh, GOC:mah, PMID:14623866]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0034086
name: maintenance of sister chromatid cohesion
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0034087
name: establishment of mitotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah]
is_a: GO:0034085 ! establishment of sister chromatid cohesion
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0034088
name: maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]
synonym: "mitotic cohesion stability" RELATED []
is_a: GO:0034086 ! maintenance of sister chromatid cohesion
relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0034089
name: establishment of meiotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah]
is_a: GO:0034085 ! establishment of sister chromatid cohesion
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0034090
name: maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah]
is_a: GO:0034086 ! maintenance of sister chromatid cohesion
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0034091
name: regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0007063 ! regulation of sister chromatid cohesion
relationship: regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034092
name: negative regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0045875 ! negative regulation of sister chromatid cohesion
relationship: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034093
name: positive regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0045876 ! positive regulation of sister chromatid cohesion
relationship: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034094
name: regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
relationship: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034095
name: negative regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
relationship: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034096
name: positive regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
relationship: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034097
name: response to cytokine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]
synonym: "response to cytokine stimulus" EXACT [GOC:dos]
is_a: GO:1901652 ! response to peptide

[Term]
id: GO:0034098
name: VCP-NPL4-UFD1 AAA ATPase complex
namespace: cellular_component
def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry)." [PMID:11813000, PMID:16179952]
synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex" NARROW []
synonym: "p97-Ufd1-Npl4 complex" EXACT [PMID:12847084]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0034099
name: luminal surveillance complex
namespace: cellular_component
def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065]
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005788 ! endoplasmic reticulum lumen

[Term]
id: GO:0034101
name: erythrocyte homeostasis
namespace: biological_process
def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397]
synonym: "RBC homeostasis" EXACT [CL:0000232]
synonym: "red blood cell homeostasis" EXACT [CL:0000232]
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0034102
name: erythrocyte clearance
namespace: biological_process
def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397]
comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont.
synonym: "neocytolysis" NARROW [PMID:14754397]
synonym: "RBC clearance" EXACT [CL:0000232]
synonym: "red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0034101 ! erythrocyte homeostasis

[Term]
id: GO:0034103
name: regulation of tissue remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add]
synonym: "regulation of tissue remodelling" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034104
name: negative regulation of tissue remodeling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add]
synonym: "negative regulation of tissue remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034105
name: positive regulation of tissue remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add]
synonym: "positive regulation of tissue remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034106
name: regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "regulation of RBC clearance" EXACT [CL:0000232]
synonym: "regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034107
name: negative regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "negative regulation of RBC clearance" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0034106 ! regulation of erythrocyte clearance
relationship: negatively_regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034108
name: positive regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "positive regulation of RBC clearance" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0034106 ! regulation of erythrocyte clearance
relationship: positively_regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034109
name: homotypic cell-cell adhesion
namespace: biological_process
def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add]
comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms.
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0034110
name: regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034111
name: negative regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034112
name: positive regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034113
name: heterotypic cell-cell adhesion
namespace: biological_process
def: "The attachment of a cell to a cell of a different type via adhesion molecules." [GOC:add]
comment: Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms.
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0034114
name: regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034115
name: negative regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion
is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation
relationship: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034116
name: positive regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion
relationship: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034117
name: erythrocyte aggregation
namespace: biological_process
def: "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules." [GOC:add, PMID:14631543]
synonym: "RBC aggregation" EXACT [CL:0000232]
synonym: "red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034118
name: regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
relationship: regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034119
name: negative regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "negative regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:0034118 ! regulation of erythrocyte aggregation
relationship: negatively_regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034120
name: positive regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "positive regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:0034118 ! regulation of erythrocyte aggregation
relationship: positively_regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034121
name: regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR signaling pathway" EXACT []
synonym: "regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034122
name: negative regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034123
name: positive regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034124
name: regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation ofMyD88-dependent TLR signaling pathway" EXACT []
synonym: "regulation ofMyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034125
name: negative regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of MyD88-dependent TLR signaling pathway" EXACT []
synonym: "negative regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034126
name: positive regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of MyD88-dependent TLR signaling pathway" EXACT []
synonym: "positive regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway
relationship: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034127
name: regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation ofMyD88-independent TLR signaling pathway" EXACT []
synonym: "regulation ofMyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034128
name: negative regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of MyD88-independent TLR signaling pathway" EXACT []
synonym: "negative regulation of MyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034129
name: positive regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of MyD88-independent TLR signaling pathway" EXACT []
synonym: "positive regulation of MyD88-independent toll-like receptor" EXACT []
synonym: "positive regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway
relationship: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034130
name: toll-like receptor 1 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 1." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR1 signaling pathway" EXACT []
synonym: "toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0002752 ! cell surface pattern recognition receptor signaling pathway

[Term]
id: GO:0034131
name: regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR1 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034132
name: negative regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR1 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway
relationship: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034133
name: positive regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR1 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034134
name: toll-like receptor 2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 2." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR2 signaling pathway" EXACT []
synonym: "toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0140895 ! cell surface toll-like receptor signaling pathway

[Term]
id: GO:0034135
name: regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR2 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034136
name: negative regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR2 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway
relationship: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034137
name: positive regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR2 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034138
name: toll-like receptor 3 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR3 signaling pathway" EXACT []
synonym: "toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0140894 ! endolysosomal toll-like receptor signaling pathway

[Term]
id: GO:0034139
name: regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR3 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034140
name: negative regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR3 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034141
name: positive regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR3 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034142
name: toll-like receptor 4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 4." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR4 signaling pathway" EXACT []
synonym: "toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0140895 ! cell surface toll-like receptor signaling pathway

[Term]
id: GO:0034143
name: regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR4 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034144
name: negative regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR4 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway
relationship: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034145
name: positive regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR4 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034146
name: toll-like receptor 5 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 5." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR5 signaling pathway" EXACT []
synonym: "toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0140895 ! cell surface toll-like receptor signaling pathway

[Term]
id: GO:0034147
name: regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR5 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034148
name: negative regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR5 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway
relationship: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034149
name: positive regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR5 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034150
name: toll-like receptor 6 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 6." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR6 signaling pathway" EXACT []
synonym: "toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0140895 ! cell surface toll-like receptor signaling pathway

[Term]
id: GO:0034151
name: regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR6 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034152
name: negative regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR6 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway
relationship: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034153
name: positive regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR6 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034154
name: toll-like receptor 7 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 7." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR7 signaling pathway" EXACT []
synonym: "toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0140894 ! endolysosomal toll-like receptor signaling pathway

[Term]
id: GO:0034155
name: regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR7 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034156
name: negative regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR7 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034157
name: positive regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR7 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034158
name: toll-like receptor 8 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 8." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR8 signaling pathway" EXACT []
synonym: "toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0140894 ! endolysosomal toll-like receptor signaling pathway

[Term]
id: GO:0034159
name: regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR8 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034160
name: negative regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR8 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034161
name: positive regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR8 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034162
name: toll-like receptor 9 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 9." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR9 signaling pathway" EXACT []
synonym: "toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0140894 ! endolysosomal toll-like receptor signaling pathway

[Term]
id: GO:0034163
name: regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR9 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034164
name: negative regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR9 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034165
name: positive regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR9 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034166
name: toll-like receptor 10 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 10." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR10 signaling pathway" EXACT []
synonym: "toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0140895 ! cell surface toll-like receptor signaling pathway

[Term]
id: GO:0034167
name: regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR10 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034168
name: negative regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR10 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway
relationship: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034169
name: positive regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR10 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034170
name: toll-like receptor 11 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 11." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR11 signaling pathway" EXACT []
synonym: "toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0140894 ! endolysosomal toll-like receptor signaling pathway

[Term]
id: GO:0034171
name: regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR11 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034172
name: negative regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR11 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034173
name: positive regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR11 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034174
name: toll-like receptor 12 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 12." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR12 signaling pathway" EXACT []
synonym: "toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0140894 ! endolysosomal toll-like receptor signaling pathway

[Term]
id: GO:0034175
name: regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR12 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034176
name: negative regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR12 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034177
name: positive regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR12 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034178
name: toll-like receptor 13 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 13." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR13 signaling pathway" EXACT []
synonym: "toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0140894 ! endolysosomal toll-like receptor signaling pathway

[Term]
id: GO:0034179
name: regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR13 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034180
name: negative regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR13 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034181
name: positive regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR13 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034182
name: regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
relationship: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034183
name: negative regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
relationship: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034184
name: positive regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
relationship: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034185
name: apolipoprotein binding
namespace: molecular_function
def: "Binding to an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0034186
name: apolipoprotein A-I binding
namespace: molecular_function
def: "Binding to apolipoprotein A-I." [GOC:BHF, GOC:rl]
is_a: GO:0034185 ! apolipoprotein binding

[Term]
id: GO:0034187
name: obsolete apolipoprotein E binding
namespace: molecular_function
def: "OBSOLETE. Binding to apolipoprotein E." [GOC:BHF, GOC:rl]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "apolipoprotein E binding" EXACT []
is_obsolete: true
replaced_by: GO:0034185

[Term]
id: GO:0034188
name: apolipoprotein A-I receptor activity
namespace: molecular_function
def: "Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:BHF, GOC:rl, GOC:signaling, PMID:16443932]
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0030226 ! apolipoprotein receptor activity

[Term]
id: GO:0034189
name: very-low-density lipoprotein particle binding
namespace: molecular_function
def: "Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm." [GOC:BHF, GOC:mah]
synonym: "very-low-density lipoprotein binding" EXACT [GOC:bf, GOC:dph]
synonym: "VLDL binding" EXACT []
is_a: GO:0005515 ! protein binding
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0034190
name: apolipoprotein receptor binding
namespace: molecular_function
def: "Binding to an apolipoprotein receptor." [GOC:BHF, GOC:rl]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0034191
name: apolipoprotein A-I receptor binding
namespace: molecular_function
def: "Binding to an apolipoprotein A-I receptor." [GOC:BHF, GOC:rl]
comment: Note that this term is to be used only to annotate gene products that bind to lipid-free APOA1. For receptors that bind lipid-associated apolipoproteins (plasma lipoprotein particles), consider annotating to 'lipoprotein receptor activity ; GO:0030228' or its child terms.
is_a: GO:0034190 ! apolipoprotein receptor binding

[Term]
id: GO:0034192
name: D-galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid." [GOC:mah]
synonym: "D-galactonate metabolism" EXACT []
is_a: GO:0019583 ! galactonate metabolic process

[Term]
id: GO:0034193
name: L-galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid." [GOC:mah]
synonym: "L-galactonate metabolism" EXACT []
is_a: GO:0019583 ! galactonate metabolic process

[Term]
id: GO:0034194
name: D-galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid." [GOC:ai, GOC:mah]
synonym: "D-galactonate breakdown" EXACT []
synonym: "D-galactonate catabolism" EXACT []
synonym: "D-galactonate degradation" EXACT []
xref: MetaCyc:GALACTCAT-PWY
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019584 ! galactonate catabolic process
is_a: GO:0034192 ! D-galactonate metabolic process

[Term]
id: GO:0034195
name: L-galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid." [GOC:ai, GOC:mah]
synonym: "L-galactonate breakdown" EXACT []
synonym: "L-galactonate catabolism" EXACT []
synonym: "L-galactonate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019584 ! galactonate catabolic process
is_a: GO:0034193 ! L-galactonate metabolic process

[Term]
id: GO:0034196
name: acylglycerol transport
namespace: biological_process
def: "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl]
synonym: "glyceride transport" EXACT []
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0034197
name: triglyceride transport
namespace: biological_process
def: "The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [GOC:BHF, GOC:rl]
synonym: "triacylglycerol transport" EXACT []
is_a: GO:0034196 ! acylglycerol transport

[Term]
id: GO:0034198
name: cellular response to amino acid starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]
synonym: "GAAC response" NARROW [PMID:29596413]
synonym: "general amino acid control response" NARROW [PMID:29596413]
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:1990928 ! response to amino acid starvation

[Term]
id: GO:0034199
name: activation of protein kinase A activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase A." [GOC:pde]
subset: gocheck_obsoletion_candidate
synonym: "protein kinase A activation" EXACT []
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0034200
name: D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate." [PMID:11279237, RHEA:28518]
synonym: "D,D-heptose 1,7-bisphosphate phosphatase activity" EXACT []
xref: EC:3.1.3.82
xref: MetaCyc:RXN0-4361
xref: RHEA:28518
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0034201
name: response to oleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:lp]
synonym: "response to oleate" EXACT [GOC:mah]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0034202
name: glycolipid floppase activity
namespace: molecular_function
def: "Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [GOC:krc, PMID:11807558]
synonym: "ATP-dependent intramembrane glycolipid transporter activity" BROAD []
synonym: "ATPase-coupled intramembrane glycolipid transporter activity" BROAD []
synonym: "glycolipid floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
synonym: "glycolipid-translocating activity" BROAD []
synonym: "M5GN2-PP-Dol flippase activity" NARROW []
synonym: "Man(5)GlcNAc(2)-PP-dolichol translocator" NARROW []
synonym: "Man5GlcNac2-PP-Dol ER flippase activity" NARROW []
xref: Reactome:R-HSA-446212 "Flipping of the N-glycan precursor to inside the ER"
xref: Reactome:R-HSA-4570573 "Defective RFT1 does not flip the N-glycan precursor"
is_a: GO:0140328 ! floppase activity

[Term]
id: GO:0034203
name: glycolipid translocation
namespace: biological_process
def: "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558]
is_a: GO:0034204 ! lipid translocation
is_a: GO:0046836 ! glycolipid transport

[Term]
id: GO:0034204
name: lipid translocation
namespace: biological_process
def: "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah]
synonym: "intramembrane lipid transfer" EXACT []
is_a: GO:0006869 ! lipid transport
is_a: GO:0097035 ! regulation of membrane lipid distribution

[Term]
id: GO:0034205
name: amyloid-beta formation
namespace: biological_process
def: "The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP)." [GOC:mah]
comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000).
synonym: "beta-amyloid formation" EXACT []
synonym: "beta-amyloid polypeptide formation from amyloid precursor protein" EXACT []
synonym: "beta-amyloid polypeptide formation from APP" EXACT []
is_a: GO:0042987 ! amyloid precursor protein catabolic process
is_a: GO:0050435 ! amyloid-beta metabolic process

[Term]
id: GO:0034206
name: enhanceosome
namespace: cellular_component
def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024]
xref: Wikipedia:Enhanceosome
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0034207
name: obsolete steroid acetylation
namespace: biological_process
def: "OBSOLETE. The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008202

[Term]
id: GO:0034208
name: obsolete steroid deacetylation
namespace: biological_process
def: "OBSOLETE. The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008202

[Term]
id: GO:0034209
name: obsolete sterol acetylation
namespace: biological_process
def: "OBSOLETE. The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0016125

[Term]
id: GO:0034210
name: obsolete sterol deacetylation
namespace: biological_process
def: "OBSOLETE. The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0016125

[Term]
id: GO:0034211
name: GTP-dependent protein kinase activity
namespace: molecular_function
def: "GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate." [GOC:ecd, PMID:17200152]
comment: The reaction requires the presence of GTP.
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0034212
name: peptide N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah]
xref: Reactome:R-HSA-3371554 "HSF1 acetylation at Lys80"
xref: Reactome:R-HSA-9760081 "CREBBP, EP300 acetylates NFE2L2"
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0034213
name: quinolinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah]
synonym: "quinolinate breakdown" EXACT []
synonym: "quinolinate catabolism" EXACT []
synonym: "quinolinate degradation" EXACT []
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046874 ! quinolinate metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0034214
name: protein hexamerization
namespace: biological_process
def: "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd]
synonym: "protein hexamer assembly" EXACT []
synonym: "protein hexamer biosynthesis" EXACT []
synonym: "protein hexamer biosynthetic process" EXACT []
synonym: "protein hexamer formation" EXACT []
is_a: GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0034215
name: thiamine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)." [GOC:mah]
synonym: "thiamin:hydrogen symporter activity" EXACT []
synonym: "thiamin:proton symporter activity" EXACT []
synonym: "thiamine:hydrogen symporter activity" EXACT []
is_a: GO:0015234 ! thiamine transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0034216
name: high-affinity thiamine:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity thiamin:hydrogen symporter activity" EXACT []
synonym: "high-affinity thiamin:hydrogen symporter activity" EXACT []
synonym: "high-affinity thiamin:proton symporter activity" EXACT []
synonym: "high-affinity thiamine:hydrogen symporter activity" EXACT []
is_a: GO:0034215 ! thiamine:proton symporter activity

[Term]
id: GO:0034217
name: obsolete ascospore wall chitin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "ascospore wall chitin anabolism" EXACT []
synonym: "ascospore wall chitin biosynthesis" EXACT []
synonym: "ascospore wall chitin formation" EXACT []
synonym: "ascospore wall chitin synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0006031

[Term]
id: GO:0034218
name: obsolete ascospore wall chitin metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "ascospore wall chitin metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006030

[Term]
id: GO:0034219
name: carbohydrate transmembrane transport
namespace: biological_process
def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "carbohydrate membrane transport" EXACT []
synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034220
name: monoatomic ion transmembrane transport
namespace: biological_process
alt_id: GO:0099131
def: "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW []
synonym: "ion membrane transport" EXACT []
synonym: "ion transmembrane transport" BROAD []
synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006811 ! monoatomic ion transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034221
name: obsolete fungal-type cell wall chitin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells." [GOC:mah]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "fungal-type cell wall chitin anabolism" EXACT []
synonym: "fungal-type cell wall chitin biosynthesis" EXACT []
synonym: "fungal-type cell wall chitin formation" EXACT []
synonym: "fungal-type cell wall chitin synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0006031

[Term]
id: GO:0034222
name: obsolete regulation of cell wall chitin metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall." [GOC:mah]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "regulation of cell wall chitin metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0032882

[Term]
id: GO:0034223
name: obsolete regulation of ascospore wall chitin biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin." [GOC:mah]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "regulation of ascospore wall chitin anabolism" EXACT []
synonym: "regulation of ascospore wall chitin biosynthesis" EXACT []
synonym: "regulation of ascospore wall chitin formation" EXACT []
synonym: "regulation of ascospore wall chitin synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0032883

[Term]
id: GO:0034224
name: cellular response to zinc ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah]
synonym: "cellular response to zinc ion limitation" EXACT []
synonym: "cellular response to zinc starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0120127 ! response to zinc ion starvation

[Term]
id: GO:0034225
name: obsolete regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation
namespace: biological_process
def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc deficiency" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation" EXACT []
is_obsolete: true
consider: GO:0006357
consider: GO:0034224

[Term]
id: GO:0034227
name: tRNA thio-modification
namespace: biological_process
def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]
synonym: "tRNA thiolation" EXACT [PMID:24774365]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0034228
name: ethanolamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579]
synonym: "2-aminoethanol transmembrane transporter activity" EXACT []
synonym: "ethanolamine permease activity" EXACT []
synonym: "monoethanolamine transmembrane transporter activity" EXACT []
xref: MetaCyc:TRANS-RXN0-476
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0034229
name: ethanolamine transport
namespace: biological_process
def: "The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579]
synonym: "2-aminoethanol transport" EXACT []
synonym: "monoethanolamine transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015837 ! amine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0034230
name: enkephalin processing
namespace: biological_process
def: "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide." [GOC:BHF, GOC:mah, GOC:rl, PMID:8262946]
synonym: "enkephalin formation" EXACT []
synonym: "peptide enkephalin formation" EXACT []
synonym: "peptide enkephalin processing" EXACT []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0034231
name: islet amyloid polypeptide processing
namespace: biological_process
def: "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP)." [GOC:BHF, GOC:rl, PMID:15983213, PMID:8262946]
synonym: "IAPP formation" EXACT []
synonym: "IAPP processing" EXACT []
synonym: "islet amyloid peptide formation" EXACT []
synonym: "islet amyloid peptide processing" EXACT []
synonym: "islet amyloid polypeptide formation" RELATED []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0034232
name: obsolete ascospore wall chitin catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "ascospore wall chitin breakdown" EXACT []
synonym: "ascospore wall chitin catabolism" EXACT []
synonym: "ascospore wall chitin degradation" EXACT []
is_obsolete: true
replaced_by: GO:0006032

[Term]
id: GO:0034233
name: obsolete regulation of cell wall chitin catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin." [GOC:mah]
comment: The reason for obsoletion is that this^Cerm is mixing biological process and cellular component.
synonym: "regulation of cell wall chitin breakdown" EXACT []
synonym: "regulation of cell wall chitin catabolism" EXACT []
synonym: "regulation of cell wall chitin degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0034234
name: obsolete regulation of ascospore wall chitin catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin." [GOC:mah]
comment: The reason for obsoletion is that this term is mixing biological process and cellular component.
synonym: "regulation of ascospore wall chitin breakdown" EXACT []
synonym: "regulation of ascospore wall chitin catabolism" EXACT []
synonym: "regulation of ascospore wall chitin degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0034235
name: GPI anchor binding
namespace: molecular_function
def: "Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]
comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached.
synonym: "glycosylphosphatidylinositol binding" EXACT []
is_a: GO:0035091 ! phosphatidylinositol binding
is_a: GO:0051861 ! glycolipid binding

[Term]
id: GO:0034236
name: protein kinase A catalytic subunit binding
namespace: molecular_function
def: "Binding to one or both of the catalytic subunits of protein kinase A." [GOC:mah]
synonym: "PKA catalytic subunit binding" EXACT []
is_a: GO:0019901 ! protein kinase binding
is_a: GO:0051018 ! protein kinase A binding

[Term]
id: GO:0034237
name: protein kinase A regulatory subunit binding
namespace: molecular_function
def: "Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]
synonym: "PKA regulatory subunit binding" EXACT []
synonym: "protein kinase A anchoring activity" RELATED []
is_a: GO:0051018 ! protein kinase A binding

[Term]
id: GO:0034238
name: macrophage fusion
namespace: biological_process
def: "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell." [GOC:sl]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0034239
name: regulation of macrophage fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034240
name: negative regulation of macrophage fusion
namespace: biological_process
def: "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0034239 ! regulation of macrophage fusion
is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion
relationship: negatively_regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034241
name: positive regulation of macrophage fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0034239 ! regulation of macrophage fusion
is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion
relationship: positively_regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034242
name: negative regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0034243
name: regulation of transcription elongation by RNA polymerase II
namespace: biological_process
alt_id: GO:0090039
def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED []
synonym: "regulation of RNA elongation from RNA polymerase II promoter" EXACT []
synonym: "regulation of transcription elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0032784 ! regulation of DNA-templated transcription elongation
relationship: regulates GO:0006368 ! transcription elongation by RNA polymerase II

[Term]
id: GO:0034244
name: negative regulation of transcription elongation by RNA polymerase II
namespace: biological_process
alt_id: GO:0090041
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "negative regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED []
synonym: "negative regulation of RNA elongation from RNA polymerase II promoter" EXACT []
synonym: "negative regulation of transcription elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation
is_a: GO:0034243 ! regulation of transcription elongation by RNA polymerase II
relationship: negatively_regulates GO:0006368 ! transcription elongation by RNA polymerase II

[Term]
id: GO:0034245
name: mitochondrial DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382]
synonym: "mitochondrial RNA polymerase complex" BROAD []
synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT []
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0098798 ! mitochondrial protein-containing complex

[Term]
id: GO:0034246
name: mitochondrial transcription factor activity
namespace: molecular_function
alt_id: GO:0000998
alt_id: GO:0001142
alt_id: GO:0001143
alt_id: GO:0001144
def: "Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175]
synonym: "mitochondrial DNA-binding transcription factor activity" NARROW []
synonym: "mitochondrial polymerase transcription factor activity" EXACT []
synonym: "mitochondrial RNA polymerase binding promoter specificity activity" EXACT []
synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "mitochondrial RNA polymerase promoter specificity activity" RELATED []
synonym: "mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding" EXACT []
synonym: "mitochondrial sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "mitochondrial sequence-specific DNA-binding transcription factor activity" NARROW []
synonym: "mitochondrial transcription initiation factor activity" EXACT []
synonym: "sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity" EXACT []
synonym: "transcription factor activity, mitochondrial proximal promoter sequence-specific binding" EXACT []
synonym: "transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding" EXACT []
synonym: "transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding" EXACT []
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0034247
name: snoRNA splicing
namespace: biological_process
def: "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah]
is_a: GO:0008380 ! RNA splicing
is_a: GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:0034248
name: regulation of amide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "regulation of amide metabolism" EXACT []
synonym: "regulation of cellular amide metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0043603 ! amide metabolic process

[Term]
id: GO:0034249
name: negative regulation of amide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "negative regulation of amide metabolism" EXACT []
synonym: "negative regulation of cellular amide metabolic process" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
relationship: negatively_regulates GO:0043603 ! amide metabolic process

[Term]
id: GO:0034250
name: positive regulation of amide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "positive regulation of amide metabolism" EXACT []
synonym: "positive regulation of cellular amide metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
relationship: positively_regulates GO:0043603 ! amide metabolic process

[Term]
id: GO:0034251
name: regulation of amide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "regulation of amide breakdown" EXACT []
synonym: "regulation of amide catabolism" EXACT []
synonym: "regulation of amide degradation" EXACT []
synonym: "regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
relationship: regulates GO:0043605 ! amide catabolic process

[Term]
id: GO:0034252
name: negative regulation of amide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "negative regulation of amide breakdown" EXACT []
synonym: "negative regulation of amide catabolism" EXACT []
synonym: "negative regulation of amide degradation" RELATED []
synonym: "negative regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0034251 ! regulation of amide catabolic process
relationship: negatively_regulates GO:0043605 ! amide catabolic process

[Term]
id: GO:0034253
name: positive regulation of amide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "positive regulation of amide breakdown" EXACT []
synonym: "positive regulation of amide catabolism" EXACT []
synonym: "positive regulation of amide degradation" RELATED []
synonym: "positive regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0034251 ! regulation of amide catabolic process
relationship: positively_regulates GO:0043605 ! amide catabolic process

[Term]
id: GO:0034254
name: regulation of urea catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea." [GOC:mah]
synonym: "regulation of urea breakdown" EXACT []
synonym: "regulation of urea catabolism" EXACT []
synonym: "regulation of urea degradation" EXACT []
is_a: GO:0034251 ! regulation of amide catabolic process
is_a: GO:0034255 ! regulation of urea metabolic process
relationship: regulates GO:0043419 ! urea catabolic process

[Term]
id: GO:0034255
name: regulation of urea metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea." [GOC:mah]
synonym: "regulation of urea metabolism" EXACT []
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
relationship: regulates GO:0019627 ! urea metabolic process

[Term]
id: GO:0034256
name: chlorophyll(ide) b reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678]
synonym: "Chl b reductase activity" EXACT []
synonym: "chlorophyll b reductase activity" EXACT []
synonym: "chlorophyllide b reductase activity" EXACT []
xref: EC:1.1.1.294
xref: MetaCyc:RXN-7678
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034257
name: nicotinamide riboside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se]
xref: MetaCyc:TRANS-RXN0-481
is_a: GO:0005337 ! nucleoside transmembrane transporter activity

[Term]
id: GO:0034258
name: nicotinamide riboside transport
namespace: biological_process
def: "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:se]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0034260
name: negative regulation of GTPase activity
namespace: biological_process
alt_id: GO:0034259
alt_id: GO:0034261
alt_id: GO:1902264
alt_id: GO:1902881
def: "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]
comment: An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
subset: gocheck_obsoletion_candidate
synonym: "down regulation of GTPase activity" EXACT []
synonym: "down regulation of Rab GTPase activity" NARROW [GOC:pf]
synonym: "down regulation of Ras GTPase activity" NARROW []
synonym: "down regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Rho GTPase activity" NARROW []
synonym: "down-regulation of GTPase activity" EXACT []
synonym: "down-regulation of Rab GTPase activity" NARROW [GOC:pf]
synonym: "down-regulation of Ras GTPase activity" NARROW []
synonym: "down-regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Rho GTPase activity" NARROW []
synonym: "downregulation of GTPase activity" EXACT []
synonym: "downregulation of Rab GTPase activity" NARROW [GOC:pf]
synonym: "downregulation of Ras GTPase activity" NARROW []
synonym: "downregulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Rho GTPase activity" NARROW []
synonym: "inhibition of GTPase activity" NARROW []
synonym: "inhibition of Rab GTPase activity" NARROW [GOC:pf]
synonym: "inhibition of Ras GTPase activity" NARROW []
synonym: "inhibition of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Rho GTPase activity" NARROW []
synonym: "negative regulation of guanosinetriphosphatase activity" EXACT []
synonym: "negative regulation of Rab GTPase activity" NARROW []
synonym: "negative regulation of Ran GTPase activity" NARROW []
synonym: "negative regulation of Ras GTPase activity" NARROW []
synonym: "negative regulation of Rho GTPase activity" NARROW []
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0034263
name: positive regulation of autophagy in response to ER overload
namespace: biological_process
def: "The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy." [GOC:mah]
synonym: "autophagy in response to endoplasmic reticulum overload" EXACT []
synonym: "autophagy in response to ER stress" EXACT []
is_a: GO:0006983 ! ER overload response
is_a: GO:0010508 ! positive regulation of autophagy

[Term]
id: GO:0034264
name: isopentenyl adenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
synonym: "isopentenyl adenine metabolism" EXACT []
synonym: "isopentenyladenine metabolic process" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0034265
name: isopentenyl adenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
synonym: "isopentenyl adenine anabolism" EXACT []
synonym: "isopentenyl adenine biosynthesis" EXACT []
synonym: "isopentenyl adenine formation" EXACT []
synonym: "isopentenyl adenine synthesis" EXACT []
synonym: "isopentenyladenine biosynthetic process" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0034264 ! isopentenyl adenine metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0034266
name: isopentenyl adenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
synonym: "isopentenyl adenine breakdown" EXACT []
synonym: "isopentenyl adenine catabolism" EXACT []
synonym: "isopentenyl adenine degradation" EXACT []
synonym: "isopentenyladenine catabolic process" EXACT []
is_a: GO:0009823 ! cytokinin catabolic process
is_a: GO:0034264 ! isopentenyl adenine metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0034267
name: discadenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah]
synonym: "discadenine metabolism" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0034268
name: discadenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah]
synonym: "discadenine anabolism" EXACT []
synonym: "discadenine biosynthesis" EXACT []
synonym: "discadenine formation" EXACT []
synonym: "discadenine synthesis" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0034267 ! discadenine metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0034269
name: discadenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah]
synonym: "discadenine breakdown" EXACT []
synonym: "discadenine catabolism" EXACT []
synonym: "discadenine degradation" EXACT []
is_a: GO:0009823 ! cytokinin catabolic process
is_a: GO:0034267 ! discadenine metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0034270
name: Cvt complex
namespace: cellular_component
def: "A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p." [GOC:rb, PMID:15659643]
synonym: "cytoplasm to vacuole targeting complex" EXACT []
synonym: "cytoplasm-to-vacuole targeting complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034271
name: phosphatidylinositol 3-kinase complex, class III, type I
namespace: cellular_component
def: "A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]
comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
synonym: "autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex" EXACT []
synonym: "phosphatidylinositol 3-kinase complex I" RELATED []
synonym: "PtdIns-3-kinase complex I" RELATED []
is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III

[Term]
id: GO:0034272
name: phosphatidylinositol 3-kinase complex, class III, type II
namespace: cellular_component
def: "A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]
comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
synonym: "phosphatidylinositol 3-kinase complex II" RELATED []
synonym: "PtdIns-3-kinase complex II" RELATED []
is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III

[Term]
id: GO:0034274
name: Atg12-Atg5-Atg16 complex
namespace: cellular_component
def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448]
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034275
name: kynurenic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [GOC:mah]
synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT []
synonym: "kynurenic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0034276
name: kynurenic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [GOC:mah]
synonym: "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT []
synonym: "kynurenic acid anabolism" EXACT []
synonym: "kynurenic acid biosynthesis" EXACT []
synonym: "kynurenic acid formation" RELATED []
synonym: "kynurenic acid synthesis" EXACT []
is_a: GO:0034275 ! kynurenic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0034277
name: ent-cassa-12,15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [EC:4.2.3.28, RHEA:25532]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity" EXACT systematic_synonym [EC:4.2.3.28, KEGG_REACTION:R09119]
xref: EC:4.2.3.28
xref: KEGG_REACTION:R09119
xref: MetaCyc:RXN-4881
xref: RHEA:25532
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034278
name: stemar-13-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [RHEA:25552]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09115]
xref: EC:4.2.3.33
xref: KEGG_REACTION:R09115
xref: MetaCyc:RXN-4882
xref: RHEA:25552
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034279
name: syn-pimara-7,15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [RHEA:25560]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09117]
xref: EC:4.2.3.35
xref: KEGG_REACTION:R09117
xref: MetaCyc:RXN-4883
xref: RHEA:25560
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034280
name: ent-sandaracopimaradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [RHEA:25536]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09120]
synonym: "ent-pimaradiene synthase activity" BROAD []
xref: EC:4.2.3.29
xref: KEGG_REACTION:R09120
xref: MetaCyc:RXN-4884
xref: RHEA:25536
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034281
name: ent-isokaurene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283]
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0034282
name: ent-pimara-8(14),15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate." [RHEA:25540]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09121]
synonym: "ent-pimaradiene synthase activity" BROAD []
xref: EC:4.2.3.30
xref: KEGG_REACTION:R09121
xref: MetaCyc:RXN-7788
xref: RHEA:25540
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034283
name: syn-stemod-13(17)-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [RHEA:25556]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09116]
synonym: "exo-stemodene synthase activity" EXACT []
synonym: "stemod-13(17)-ene synthase activity" EXACT []
synonym: "stemodene synthase activity" EXACT []
synonym: "syn-stemodene synthase activity" EXACT []
xref: EC:4.2.3.34
xref: KEGG_REACTION:R09116
xref: MetaCyc:RXN-9291
xref: RHEA:25556
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034284
name: response to monosaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah]
synonym: "response to monosaccharide stimulus" EXACT [GOC:dos]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0034285
name: response to disaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:sart]
synonym: "response to disaccharide stimulus" EXACT [GOC:dos]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0034286
name: response to maltose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:sart]
synonym: "response to maltose stimulus" EXACT [GOC:dos]
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0034287
name: detection of monosaccharide stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal." [GOC:mah]
synonym: "perception of monosaccharide stimulus" RELATED []
is_a: GO:0009730 ! detection of carbohydrate stimulus
is_a: GO:0034284 ! response to monosaccharide

[Term]
id: GO:0034288
name: detection of disaccharide stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal." [GOC:sart]
synonym: "perception of disaccharide stimulus" RELATED []
is_a: GO:0009730 ! detection of carbohydrate stimulus
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0034289
name: detection of maltose stimulus
namespace: biological_process
def: "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart]
synonym: "perception of maltose stimulus" RELATED []
is_a: GO:0034286 ! response to maltose
is_a: GO:0034288 ! detection of disaccharide stimulus

[Term]
id: GO:0034293
name: sexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of meiosis." [GOC:mah]
synonym: "meiotic spore formation" EXACT []
synonym: "meiotic sporulation" EXACT []
synonym: "sexual spore formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0043934 ! sporulation
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0034294
name: sexual spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:mah]
synonym: "sexual spore wall formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042244 ! spore wall assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0034293 ! sexual sporulation

[Term]
id: GO:0034295
name: basidiospore formation
namespace: biological_process
def: "The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:di, GOC:ds, GOC:mah, GOC:mcc, https://en.wikipedia.org/wiki/Basidiospore]
comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked.
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034296
name: zygospore formation
namespace: biological_process
def: "The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, PMID:21858438]
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034297
name: oidium formation
namespace: biological_process
def: "The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus." [GOC:mah, https://doi.org/10.1007/BF02464287]
is_a: GO:0030436 ! asexual sporulation

[Term]
id: GO:0034298
name: arthrospore formation
namespace: biological_process
def: "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation." [GOC:mah]
synonym: "arthroconidium formation" EXACT []
is_a: GO:0048315 ! conidium formation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0034299
name: reproductive blastospore formation
namespace: biological_process
def: "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota." [GOC:mah, PMID:30910084]
comment: Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species.
synonym: "blastoconidium formation" EXACT []
is_a: GO:0048315 ! conidium formation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0034300
name: sporangiospore formation
namespace: biological_process
def: "The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:ds, GOC:mah, PMID:32839172]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034301
name: endospore formation
namespace: biological_process
def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034302
name: akinete formation
namespace: biological_process
def: "The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria." [GOC:ds, GOC:mah, https://doi.org/10.1016/S1369-703X(02)00136-5, PMID:11948167]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034303
name: myxospore formation
namespace: biological_process
def: "The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, desiccation, and UV than vegetative myxobacteria." [GOC:ds, ISBN:0122268008]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034304
name: actinomycete-type spore formation
namespace: biological_process
def: "The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales." [GOC:ds, ISBN:0122268008]
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034305
name: regulation of asexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah]
synonym: "regulation of asexual spore formation" EXACT []
synonym: "regulation of mitotic spore formation" EXACT []
synonym: "regulation of mitotic sporulation" EXACT []
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:1903664 ! regulation of asexual reproduction
relationship: regulates GO:0030436 ! asexual sporulation

[Term]
id: GO:0034306
name: regulation of sexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah]
synonym: "MAPKKK cascade during sporulation" RELATED []
synonym: "regulation of meiotic spore formation" EXACT []
synonym: "regulation of meiotic sporulation" EXACT []
synonym: "regulation of sexual spore formation" EXACT []
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051445 ! regulation of meiotic cell cycle
relationship: regulates GO:0034293 ! sexual sporulation

[Term]
id: GO:0034307
name: regulation of ascospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah]
synonym: "MAPKKK cascade during sporulation" RELATED []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0034308
name: primary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]
synonym: "monohydric alcohol metabolic process" EXACT []
synonym: "primary alcohol metabolism" EXACT [GOC:mah]
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0034309
name: primary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]
synonym: "monohydric alcohol biosynthetic process" EXACT []
synonym: "primary alcohol anabolism" EXACT [GOC:mah]
synonym: "primary alcohol biosynthesis" EXACT [GOC:mah]
synonym: "primary alcohol formation" EXACT [GOC:mah]
synonym: "primary alcohol synthesis" EXACT [GOC:mah]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0034310
name: primary alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]
synonym: "monohydric alcohol catabolic process" EXACT []
synonym: "primary alcohol breakdown" EXACT [GOC:mah]
synonym: "primary alcohol catabolism" EXACT [GOC:mah]
synonym: "primary alcohol degradation" EXACT [GOC:mah]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0034311
name: diol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic." [GOC:curators]
synonym: "dihydric alcohol metabolic process" RELATED []
synonym: "diol metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:0034312
name: diol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]
synonym: "dihydric alcohol biosynthetic process" EXACT []
synonym: "diol anabolism" EXACT []
synonym: "diol biosynthesis" EXACT []
synonym: "diol formation" EXACT []
synonym: "diol synthesis" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0034313
name: diol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]
synonym: "dihydric alcohol catabolic process" EXACT []
synonym: "diol breakdown" EXACT []
synonym: "diol catabolism" EXACT []
synonym: "diol degradation" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0034314
name: Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]
synonym: "actin filament branch nucleation" EXACT []
synonym: "branched actin filament nucleation" EXACT []
is_a: GO:0045010 ! actin nucleation

[Term]
id: GO:0034315
name: regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]
is_a: GO:0051125 ! regulation of actin nucleation
relationship: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation

[Term]
id: GO:0034316
name: negative regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963]
is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation
is_a: GO:0051126 ! negative regulation of actin nucleation
relationship: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation

[Term]
id: GO:0034317
name: nicotinate riboside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + beta-D-ribosylnicotinate = ADP + H+ + nicotinate beta-D-ribonucleotide." [PMID:17914902, RHEA:25568]
synonym: "nicotinic acid riboside kinase" EXACT []
synonym: "ribosylnicotinic acid kinase" EXACT []
xref: EC:2.7.1.173
xref: MetaCyc:RXN-8443
xref: RHEA:25568
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0034318
name: alcohol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah]
synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT []
synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW []
synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT []
synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW []
synonym: "AEATase activity" NARROW []
synonym: "alcohol acyltransferase activity" EXACT []
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0034319
name: obsolete alcohol O-butanoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250]
comment: This term was obsoleted because it represents a specific substrate of alcohol O-acetyltransferase activity ; GO:0004026.
is_obsolete: true
replaced_by: GO:0004026

[Term]
id: GO:0034320
name: obsolete alcohol O-hexanoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250]
comment: This term was obsoleted because it represents a specific substrate of alcohol O-acetyltransferase activity ; GO:0004026.
is_obsolete: true
replaced_by: GO:0004026

[Term]
id: GO:0034321
name: obsolete alcohol O-octanoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250]
comment: This term was obsoleted because it represents a specific substrate of alcohol O-acetyltransferase activity ; GO:0004026.
is_obsolete: true
replaced_by: GO:0004026

[Term]
id: GO:0034322
name: obsolete alcohol O-decanoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250]
comment: This term was obsoleted because it represents a specific substrate of alcohol O-acetyltransferase activity ; GO:0004026.
is_obsolete: true
replaced_by: GO:0004026

[Term]
id: GO:0034323
name: O-butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034326 ! butanoyltransferase activity

[Term]
id: GO:0034324
name: O-hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034327 ! hexanoyltransferase activity

[Term]
id: GO:0034325
name: O-decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034328 ! decanoyltransferase activity

[Term]
id: GO:0034326
name: butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0034327
name: hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0034328
name: decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0034329
name: cell junction assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0034330
name: cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "cell junction assembly and maintenance" EXACT []
synonym: "cell junction biogenesis" RELATED []
synonym: "cell junction organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0034331
name: cell junction maintenance
namespace: biological_process
def: "The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0034330 ! cell junction organization
is_a: GO:0043954 ! cellular component maintenance

[Term]
id: GO:0034332
name: adherens junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]
synonym: "adherens junction organisation" EXACT []
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0034333
name: adherens junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:mah]
synonym: "adherens junction formation" EXACT []
is_a: GO:0007043 ! cell-cell junction assembly
is_a: GO:0034332 ! adherens junction organization

[Term]
id: GO:0034334
name: adherens junction maintenance
namespace: biological_process
def: "The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:mah]
is_a: GO:0034332 ! adherens junction organization
is_a: GO:0045217 ! cell-cell junction maintenance

[Term]
id: GO:0034335
name: DNA negative supercoiling activity
namespace: molecular_function
def: "Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:DNA_gyrase]
comment: Note that this term was reinstated from obsolete.
synonym: "DNA gyrase activity" RELATED []
synonym: "DNA-gyrase activity" RELATED []
is_a: GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

[Term]
id: GO:0034336
name: misfolded RNA binding
namespace: molecular_function
def: "Binding to an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192]
synonym: "RNA chaperone" RELATED []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034337
name: RNA folding
namespace: biological_process
def: "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure." [GOC:mah, PMID:10393192]
synonym: "RNA chaperone" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0034338
name: short-chain carboxylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp]
synonym: "butyrate esterase activity" NARROW []
synonym: "butyryl esterase activity" NARROW []
synonym: "methylbutyrase activity" NARROW []
synonym: "methylbutyrate esterase activity" NARROW []
synonym: "monobutyrase activity" NARROW []
synonym: "propionyl esterase activity" NARROW []
synonym: "short-chain esterase activity" BROAD []
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0034339
name: obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
namespace: biological_process
def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GO_REF:0000021, GOC:mah, GOC:mh]
comment: This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand.
synonym: "regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT []
is_obsolete: true
consider: GO:0003713
consider: GO:0004879
consider: GO:0006357
consider: GO:0030522

[Term]
id: GO:0034340
name: response to type I interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "response to type I IFN" EXACT []
is_a: GO:0034097 ! response to cytokine
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034341
name: response to type II interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:add, ISBN:0126896631, PMID:15546383]
synonym: "response to gamma-interferon" RELATED []
synonym: "response to immune interferon" EXACT []
synonym: "response to interferon-gamma" BROAD []
synonym: "response to type II IFN" BROAD []
is_a: GO:0034097 ! response to cytokine
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034342
name: response to type III interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
synonym: "response to interferon-lambda" NARROW []
synonym: "response to type III IFN" EXACT []
is_a: GO:0034097 ! response to cytokine
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034343
name: type III interferon production
namespace: biological_process
alt_id: GO:0072644
def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. This term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
synonym: "type III IFN production" EXACT []
synonym: "type III interferon secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0034344
name: regulation of type III interferon production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "regulation of type III IFN production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034345
name: negative regulation of type III interferon production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "down regulation of type III interferon production" EXACT []
synonym: "down-regulation of type III interferon production" EXACT []
synonym: "downregulation of type III interferon production" EXACT []
synonym: "inhibition of type III interferon production" NARROW []
synonym: "negative regulation of type III IFN production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0034344 ! regulation of type III interferon production
relationship: negatively_regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034346
name: positive regulation of type III interferon production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "activation of type III interferon production" NARROW []
synonym: "positive regulation of type III IFN production" EXACT []
synonym: "stimulation of type III interferon production" NARROW []
synonym: "up regulation of type III interferon production" EXACT []
synonym: "up-regulation of type III interferon production" EXACT []
synonym: "upregulation of type III interferon production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0034344 ! regulation of type III interferon production
relationship: positively_regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034347
name: type III interferon binding
namespace: molecular_function
def: "Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "interferon-lambda binding" NARROW []
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0034348
name: type III interferon receptor activity
namespace: molecular_function
def: "Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "interferon-lambda receptor activity" NARROW [PR:000001362]
is_a: GO:0004904 ! interferon receptor activity

[Term]
id: GO:0034349
name: glial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart]
synonym: "apoptosis of glia" EXACT []
synonym: "apoptosis of glial cells" EXACT []
synonym: "glia apoptosis" EXACT []
synonym: "glia programmed cell death by apoptosis" EXACT []
synonym: "glial cell apoptosis" NARROW []
synonym: "glial cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of glia by apoptosis" EXACT []
synonym: "programmed cell death of glial cells by apoptosis" EXACT []
synonym: "programmed cell death, glia" EXACT []
synonym: "programmed cell death, glial cells" EXACT []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0034350
name: regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of glial cell apoptosis" RELATED []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034351
name: negative regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "down regulation of glial cell apoptosis" EXACT []
synonym: "down-regulation of glial cell apoptosis" EXACT []
synonym: "downregulation of glial cell apoptosis" EXACT []
synonym: "inhibition of glial cell apoptosis" NARROW []
synonym: "negative regulation of glial cell apoptosis" NARROW []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
relationship: negatively_regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034352
name: positive regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "activation of glial cell apoptosis" NARROW []
synonym: "positive regulation of glial cell apoptosis" NARROW []
synonym: "stimulation of glial cell apoptosis" NARROW []
synonym: "up regulation of glial cell apoptosis" EXACT []
synonym: "up-regulation of glial cell apoptosis" EXACT []
synonym: "upregulation of glial cell apoptosis" EXACT []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
relationship: positively_regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034353
name: mRNA 5'-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662]
synonym: "RNA pyrophosphohydrolase activity" BROAD []
is_a: GO:0016462 ! pyrophosphatase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0034354
name: 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604]
synonym: "de novo NAD biosynthetic process from tryptophan" RELATED []
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0034627 ! 'de novo' NAD biosynthetic process

[Term]
id: GO:0034355
name: NAD salvage
namespace: biological_process
def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681, PMID:27374990]
synonym: "NAD salvage pathway" EXACT []
is_a: GO:0009435 ! NAD biosynthetic process
is_a: GO:0019365 ! pyridine nucleotide salvage
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0034356
name: NAD biosynthesis via nicotinamide riboside salvage pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside." [PMID:17482543]
synonym: "nicotinamide riboside salvage pathway" EXACT []
synonym: "NR salvage pathway" EXACT []
is_a: GO:0009435 ! NAD biosynthetic process

[Term]
id: GO:0034357
name: photosynthetic membrane
namespace: cellular_component
def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah]
is_a: GO:0016020 ! membrane
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0034358
name: plasma lipoprotein particle
namespace: cellular_component
def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:BHF, GOC:expert_pt, GOC:rl]
is_a: GO:1990777 ! lipoprotein particle
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0034359
name: mature chylomicron
namespace: cellular_component
def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0042627 ! chylomicron

[Term]
id: GO:0034360
name: chylomicron remnant
namespace: cellular_component
def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0042627 ! chylomicron

[Term]
id: GO:0034361
name: very-low-density lipoprotein particle
namespace: cellular_component
def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "very-low-density lipoprotein complex" EXACT []
synonym: "VLDL complex" EXACT []
synonym: "VLDL particle" EXACT []
is_a: GO:0034385 ! triglyceride-rich plasma lipoprotein particle

[Term]
id: GO:0034362
name: low-density lipoprotein particle
namespace: cellular_component
def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "LDL complex" EXACT []
synonym: "LDL particle" EXACT []
synonym: "low-density lipoprotein complex" EXACT []
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034363
name: intermediate-density lipoprotein particle
namespace: cellular_component
def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL complex" EXACT []
synonym: "IDL particle" EXACT []
synonym: "intermediate-density lipoprotein complex" EXACT []
is_a: GO:0034385 ! triglyceride-rich plasma lipoprotein particle

[Term]
id: GO:0034364
name: high-density lipoprotein particle
namespace: cellular_component
def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl]
synonym: "HDL complex" EXACT []
synonym: "HDL particle" EXACT []
synonym: "HDL2" RELATED []
synonym: "HDL3" RELATED []
synonym: "high-density lipoprotein class complex" EXACT []
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034365
name: discoidal high-density lipoprotein particle
namespace: cellular_component
def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "discoidal HDL" EXACT []
synonym: "nascent HDL" EXACT []
synonym: "nascent high-density lipoprotein particle" EXACT []
is_a: GO:0034364 ! high-density lipoprotein particle

[Term]
id: GO:0034366
name: spherical high-density lipoprotein particle
namespace: cellular_component
def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "mature HDL" EXACT []
synonym: "mature high-density lipoprotein particle" EXACT []
synonym: "spherical HDL" EXACT []
is_a: GO:0034364 ! high-density lipoprotein particle

[Term]
id: GO:0034367
name: protein-containing complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl]
synonym: "macromolecular complex remodeling" RELATED []
synonym: "macromolecular complex remodelling" RELATED []
synonym: "protein-containing complex remodelling" EXACT []
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0034368
name: protein-lipid complex remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "protein-lipid complex remodelling" EXACT []
is_a: GO:0034367 ! protein-containing complex remodeling
is_a: GO:0071825 ! protein-lipid complex organization

[Term]
id: GO:0034369
name: plasma lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "plasma lipoprotein particle remodelling" EXACT []
is_a: GO:0034368 ! protein-lipid complex remodeling
is_a: GO:0071827 ! plasma lipoprotein particle organization
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels

[Term]
id: GO:0034370
name: triglyceride-rich lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "triacylglycerol-rich lipoprotein particle remodeling" EXACT [GOC:mah]
synonym: "triacylglycerol-rich lipoprotein particle remodelling" EXACT []
synonym: "triglyceride-rich lipoprotein particle remodelling" EXACT []
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034371
name: chylomicron remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "chylomicron remnant formation" RELATED []
synonym: "chylomicron remodelling" EXACT []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034372
name: very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "VDL formation" RELATED []
synonym: "VDL remodeling" EXACT []
synonym: "VDL remodelling" EXACT []
synonym: "very-low-density lipoprotein particle remodelling" EXACT []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034373
name: intermediate-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL remodeling" EXACT []
synonym: "IDL remodelling" EXACT []
synonym: "intermediate-density lipoprotein particle formation" RELATED []
synonym: "intermediate-density lipoprotein particle remodelling" EXACT []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034374
name: low-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "LDL remodeling" EXACT []
synonym: "LDL remodelling" EXACT []
synonym: "low-density lipoprotein particle remodelling" EXACT []
synonym: "small dense LDL formation" RELATED [GOC:BHF]
synonym: "small dense low-density lipoprotein particle formation" RELATED [GOC:BHF]
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034375
name: high-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "HDL remodeling" EXACT []
synonym: "HDL remodelling" EXACT []
synonym: "high-density lipoprotein particle remodelling" EXACT []
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034376
name: conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle
namespace: biological_process
def: "The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle." [GOC:BHF, GOC:mah, GOC:pde]
synonym: "conversion of discoidal HDL to spherical HDL" EXACT []
synonym: "discoidal HDL remodeling" RELATED []
synonym: "discoidal high-density lipoprotein remodeling" RELATED []
is_a: GO:0034375 ! high-density lipoprotein particle remodeling

[Term]
id: GO:0034377
name: plasma lipoprotein particle assembly
namespace: biological_process
def: "The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle." [GOC:BHF, GOC:mah]
is_a: GO:0065005 ! protein-lipid complex assembly
is_a: GO:0071827 ! plasma lipoprotein particle organization
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels

[Term]
id: GO:0034378
name: chylomicron assembly
namespace: biological_process
def: "The non-covalent aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron." [GOC:BHF, GOC:mah]
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034379
name: very-low-density lipoprotein particle assembly
namespace: biological_process
def: "The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle." [GOC:BHF, GOC:mah]
synonym: "VLDL assembly" EXACT []
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034380
name: high-density lipoprotein particle assembly
namespace: biological_process
def: "The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:mah]
synonym: "HDL assembly" EXACT []
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034381
name: plasma lipoprotein particle clearance
namespace: biological_process
def: "The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb]
synonym: "lipoprotein particle clearance" EXACT [GOC:mah]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels

[Term]
id: GO:0034382
name: chylomicron remnant clearance
namespace: biological_process
def: "The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF, GOC:mah, GOC:pde]
is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance

[Term]
id: GO:0034383
name: low-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah]
synonym: "LDL clearance" EXACT []
is_a: GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0034384
name: high-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah]
synonym: "HDL clearance" EXACT []
is_a: GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0034385
name: triglyceride-rich plasma lipoprotein particle
namespace: cellular_component
def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "triacylglycerol-rich lipoprotein particle" NARROW [GOC:mah]
synonym: "triglyceride-rich lipoprotein particle" BROAD [GOC:mah]
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034386
name: 4-aminobutyrate:2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde." [RHEA:23352]
synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutaric acid transaminase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-alpha-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "GABA-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" RELATED [EC:2.6.1.19]
xref: EC:2.6.1.19
xref: MetaCyc:GABATRANSAM-RXN
xref: RHEA:23352
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0034387
name: 4-aminobutyrate:pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine. Also converts glyoxylate to glycine." [EC:2.6.1.96]
synonym: "gamma-aminobutyric acid pyruvate transaminase activity" RELATED [EC:2.6.1.96]
xref: EC:2.6.1.96
xref: MetaCyc:RXN-6902
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0034388
name: Pwp2p-containing subcomplex of 90S preribosome
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "25-30 S subcomplex of 90S preribosome" EXACT []
synonym: "UTP-B complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005730 ! nucleolus
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034389
name: lipid droplet organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]
synonym: "adiposome organization" EXACT []
synonym: "lipid body organization" EXACT []
synonym: "lipid particle organisation" EXACT []
synonym: "lipid particle organization" EXACT []
synonym: "lipid particle organization and biogenesis" BROAD [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0034390
name: smooth muscle cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]
synonym: "apoptosis of smooth muscle cells" EXACT []
synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT []
synonym: "programmed cell death, smooth muscle cells" EXACT []
synonym: "SMC apoptosis" EXACT []
synonym: "smooth muscle cell apoptosis" NARROW []
synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT []
is_a: GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0034391
name: regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "regulation of SMC apoptosis" EXACT []
synonym: "regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
relationship: regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034392
name: negative regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "down regulation of smooth muscle cell apoptosis" EXACT []
synonym: "down-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "downregulation of smooth muscle cell apoptosis" EXACT []
synonym: "inhibition of smooth muscle cell apoptosis" NARROW []
synonym: "negative regulation of SMC apoptosis" EXACT []
synonym: "negative regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034393
name: positive regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "activation of smooth muscle cell apoptosis" NARROW []
synonym: "positive regulation of SMC apoptosis" EXACT []
synonym: "positive regulation of smooth muscle cell apoptosis" NARROW []
synonym: "stimulation of smooth muscle cell apoptosis" NARROW []
synonym: "up regulation of smooth muscle cell apoptosis" EXACT []
synonym: "up-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "upregulation of smooth muscle cell apoptosis" EXACT []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034394
name: protein localization to cell surface
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]
synonym: "protein localisation at cell surface" EXACT [GOC:mah]
synonym: "protein localization at cell surface" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0034395
name: obsolete regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GO_REF:0000021, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of specific transcription from RNA polymerase II promoter in response to iron" EXACT []
is_obsolete: true
consider: GO:0006357
consider: GO:0071281

[Term]
id: GO:0034396
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW []
synonym: "negative regulation of transcription from Pol II promoter in response to iron" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0071281

[Term]
id: GO:0034397
name: telomere localization
namespace: biological_process
def: "Any process in which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah, GOC:vw]
synonym: "telomere localisation" EXACT [GOC:mah]
is_a: GO:0050000 ! chromosome localization

[Term]
id: GO:0034398
name: telomere tethering at nuclear periphery
namespace: biological_process
def: "The process in which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah]
is_a: GO:0034397 ! telomere localization

[Term]
id: GO:0034399
name: nuclear periphery
namespace: cellular_component
def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0034400
name: gerontoplast
namespace: cellular_component
def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:24668747]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0034401
name: obsolete chromatin organization involved in regulation of transcription
namespace: biological_process
alt_id: GO:1903756
alt_id: GO:1903757
def: "OBSOLETE. Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators, PMID:21102443]
comment: This term was obsoleted because these it was redundant with other terms: heterochromatin assembly and regulation of gene expression, epigenetic.
synonym: "activation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter by histone modification" NARROW []
synonym: "positive regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "regulation of transcription by chromatin organisation" EXACT [GOC:mah]
synonym: "regulation of transcription by chromatin organization" EXACT []
synonym: "regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter by histone modification" NARROW []
synonym: "regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:0034402
name: obsolete recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "OBSOLETE. The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0034403
name: alignment of 3' and 5' splice sites of mRNA
namespace: biological_process
def: "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur." [GOC:krc, PMID:9430647]
synonym: "alignment of 3' and 5' splice sites of nuclear mRNA" EXACT [GOC:vw]
is_a: GO:0000389 ! mRNA 3'-splice site recognition
is_a: GO:0000395 ! mRNA 5'-splice site recognition
relationship: part_of GO:0000350 ! generation of catalytic spliceosome for second transesterification step

[Term]
id: GO:0034404
name: nucleobase-containing small molecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah]
synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT []
synonym: "nucleobase, nucleoside and nucleotide formation" EXACT []
synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT []
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0034405
name: response to fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:sl]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0034406
name: cell wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall beta-glucan metabolism" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0034407
name: cell wall (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "cell wall 1,3-beta-glucan metabolic process" BROAD []
synonym: "cell wall 1,3-beta-glucan metabolism" EXACT []
synonym: "cell wall beta-1,3 glucan metabolic process" EXACT []
synonym: "cell wall beta-1,3 glucan metabolism" EXACT []
is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process
is_a: GO:0034406 ! cell wall beta-glucan metabolic process

[Term]
id: GO:0034408
name: ascospore wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall beta-glucan metabolism" EXACT []
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0034409
name: ascospore wall (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "ascospore wall 1,3-beta-glucan metabolic process" BROAD []
synonym: "ascospore wall 1,3-beta-glucan metabolism" EXACT [GOC:mah]
synonym: "ascospore wall beta-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall beta-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process
is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process

[Term]
id: GO:0034410
name: cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall beta-glucan anabolism" EXACT []
synonym: "cell wall beta-glucan biosynthesis" EXACT []
synonym: "cell wall beta-glucan formation" EXACT []
synonym: "cell wall beta-glucan synthesis" EXACT []
is_a: GO:0034406 ! cell wall beta-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0034411
name: cell wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "cell wall 1,3-beta-glucan anabolism" EXACT []
synonym: "cell wall 1,3-beta-glucan biosynthesis" EXACT []
synonym: "cell wall 1,3-beta-glucan biosynthetic process" BROAD []
synonym: "cell wall 1,3-beta-glucan formation" EXACT []
synonym: "cell wall 1,3-beta-glucan synthesis" EXACT []
synonym: "cell wall beta-1,3-glucan anabolism" EXACT []
synonym: "cell wall beta-1,3-glucan biosynthesis" EXACT []
synonym: "cell wall beta-1,3-glucan biosynthetic process" EXACT []
synonym: "cell wall beta-1,3-glucan formation" EXACT []
synonym: "cell wall beta-1,3-glucan synthesis" EXACT []
is_a: GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process
is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process

[Term]
id: GO:0034412
name: ascospore wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall beta-glucan anabolism" EXACT []
synonym: "ascospore wall beta-glucan biosynthesis" EXACT []
synonym: "ascospore wall beta-glucan formation" EXACT []
synonym: "ascospore wall beta-glucan synthesis" EXACT []
is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process
is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process

[Term]
id: GO:0034413
name: ascospore wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "ascospore wall 1,3-beta-glucan anabolism" EXACT []
synonym: "ascospore wall 1,3-beta-glucan biosynthesis" EXACT []
synonym: "ascospore wall 1,3-beta-glucan biosynthetic process" BROAD []
synonym: "ascospore wall 1,3-beta-glucan formation" EXACT []
synonym: "ascospore wall 1,3-beta-glucan synthesis" EXACT []
synonym: "ascospore wall beta-1,3-glucan anabolism" EXACT []
synonym: "ascospore wall beta-1,3-glucan biosynthesis" EXACT []
synonym: "ascospore wall beta-1,3-glucan biosynthetic process" EXACT []
synonym: "ascospore wall beta-1,3-glucan formation" EXACT []
synonym: "ascospore wall beta-1,3-glucan synthesis" EXACT []
is_a: GO:0034409 ! ascospore wall (1->3)-beta-D-glucan metabolic process
is_a: GO:0034412 ! ascospore wall beta-glucan biosynthetic process
is_a: GO:0071970 ! fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0034414
name: obsolete tRNA 3'-trailer cleavage, endonucleolytic
namespace: biological_process
def: "OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah]
comment: The reason for obsoletion is that the term represents a molecular function.
synonym: "endonucleolytic tRNA 3'-end cleavage" EXACT []
synonym: "endonucleolytic tRNA 3'-trailer cleavage" RELATED []
synonym: "tRNA 3'-end cleavage, endonucleolytic" EXACT []
is_obsolete: true
replaced_by: GO:0042780

[Term]
id: GO:0034415
name: obsolete tRNA 3'-trailer cleavage, exonucleolytic
namespace: biological_process
def: "OBSOLETE. Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah]
comment: The reason for obsoletion is that the term represents a molecular functions.
synonym: "exonucleolytic tRNA 3'-end cleavage" EXACT []
synonym: "exonucleolytic tRNA 3'-trailer cleavage" EXACT []
synonym: "tRNA 3'-end cleavage, exonucleolytic" EXACT []
is_obsolete: true
replaced_by: GO:0042780

[Term]
id: GO:0034416
name: obsolete bisphosphoglycerate phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [GOC:mah, PMID:18413611]
comment: This term was obsoleted because it is not different from its child bisphosphoglycerate 3-phosphatase activity ; GO:0034417.
synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT []
synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT []
synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT []
synonym: "diphosphoglycerate phosphatase activity" EXACT []
synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT []
is_obsolete: true
replaced_by: GO:0034417

[Term]
id: GO:0034417
name: bisphosphoglycerate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate." [GOC:mah, PMID:18413611, RHEA:27381]
synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" RELATED [EC:3.1.3.80]
xref: EC:3.1.3.80
xref: KEGG_REACTION:R09532
xref: MetaCyc:RXN-11102
xref: RHEA:27381
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0034418
name: urate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine." [GOC:mah]
synonym: "urate anabolism" RELATED []
synonym: "urate biosynthesis" EXACT []
synonym: "urate formation" EXACT []
synonym: "urate synthesis" EXACT []
synonym: "uric acid biosynthetic process" EXACT []
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046415 ! urate metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0034419
name: obsolete L-2-hydroxyglutarate oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + hydrogen peroxide." [PMID:18390652]
comment: This term was obsoleted because this activity is not believed to exist.
is_obsolete: true
consider: GO:0140696

[Term]
id: GO:0034420
name: obsolete co-translational protein acetylation
namespace: biological_process
def: "OBSOLETE. The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "co-translational protein amino acid acetylation" EXACT [GOC:bf]
synonym: "cotranslational protein amino acid acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034421
name: post-translational protein acetylation
namespace: biological_process
def: "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "post-translational protein amino acid acetylation" EXACT [GOC:bf]
synonym: "posttranslational protein amino acid acetylation" EXACT []
is_a: GO:0006473 ! protein acetylation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0034422
name: aleurone grain lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0033095 ! aleurone grain

[Term]
id: GO:0034423
name: autophagosome lumen
namespace: cellular_component
def: "The volume enclosed within the autophagosome double-membrane." [GOC:autophagy, GOC:rph]
comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation.
synonym: "autophagic vacuole lumen" EXACT [GOC:autophagy]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0005776 ! autophagosome

[Term]
id: GO:0034424
name: Vps55/Vps68 complex
namespace: cellular_component
def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0034425
name: etioplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0034426
name: etioplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0034425 ! etioplast envelope

[Term]
id: GO:0034427
name: obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah]
comment: The reason for obsoletion is that this represents an unnecessary grouping term
is_obsolete: true
replaced_by: GO:0000956

[Term]
id: GO:0034428
name: obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0000956

[Term]
id: GO:0034429
name: tectobulbar tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain." [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0034430
name: monolayer-surrounded lipid storage body outer lipid monolayer
namespace: cellular_component
def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph]
synonym: "lipid droplet outer lipid monolayer" RELATED []
synonym: "lipid storage body surface lipid monolayer" EXACT []
synonym: "oil body outer lipid monolayer" EXACT []
synonym: "oleosome outer lipid monolayer" EXACT []
synonym: "spherosome outer lipid monolayer" EXACT []
is_a: GO:0034646 ! organelle-enclosing lipid monolayer
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0012511 ! monolayer-surrounded lipid storage body

[Term]
id: GO:0034431
name: bis(5'-adenosyl)-hexaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008, RHEA:32047]
synonym: "AP(6)A hydrolase activity" EXACT []
synonym: "AP-6-A hydrolase activity" EXACT []
synonym: "AP6A hydrolase activity" EXACT []
synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT []
xref: RHEA:32047
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0034432
name: bis(5'-adenosyl)-pentaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008]
synonym: "AP(5)A hydrolase activity" EXACT []
synonym: "AP-5-A hydrolase activity" EXACT []
synonym: "AP5A hydrolase activity" EXACT []
synonym: "Ap5a pyrophosphohydrolase activity" EXACT [GOC:tb]
synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT []
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0034433
name: obsolete steroid esterification
namespace: biological_process
def: "OBSOLETE. A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0034434
name: obsolete sterol esterification
namespace: biological_process
def: "OBSOLETE. A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008203

[Term]
id: GO:0034435
name: obsolete cholesterol esterification
namespace: biological_process
def: "OBSOLETE. A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008203

[Term]
id: GO:0034436
name: glycoprotein transport
namespace: biological_process
def: "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0015031 ! protein transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0034437
name: obsolete glycoprotein transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a glycoprotein from one side of a membrane to the other." [GOC:BHF, GOC:mah, GOC:rl]
comment: This term was obsoleted because there is no transmembrane transporter specific for glycoproteins.
synonym: "glycoprotein transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0034438
name: obsolete lipoprotein amino acid oxidation
namespace: biological_process
def: "OBSOLETE. The modification of a lipoprotein by oxidation of one or more amino acids in the protein." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0034439
name: lipoprotein lipid oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:mah]
is_a: GO:0034440 ! lipid oxidation
is_a: GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034440
name: lipid oxidation
namespace: biological_process
def: "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah]
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034441
name: plasma lipoprotein particle oxidation
namespace: biological_process
def: "The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids." [GOC:BHF, GOC:mah]
synonym: "plasma lipoprotein oxidation" RELATED [GOC:dph]
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034442
name: regulation of lipoprotein oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah]
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
relationship: regulates GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034443
name: negative regulation of lipoprotein oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah]
synonym: "inhibition of lipoprotein oxidation" NARROW []
is_a: GO:0034442 ! regulation of lipoprotein oxidation
is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process
relationship: negatively_regulates GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034444
name: regulation of plasma lipoprotein oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah]
synonym: "regulation of plasma lipoprotein particle oxidation" RELATED [GOC:dph]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0034441 ! plasma lipoprotein particle oxidation

[Term]
id: GO:0034445
name: negative regulation of plasma lipoprotein oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah]
synonym: "inhibition of plasma lipoprotein oxidation" NARROW []
synonym: "negative regulation of plasma lipoprotein particle oxidation" RELATED [GOC:dph]
is_a: GO:0034444 ! regulation of plasma lipoprotein oxidation
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0034441 ! plasma lipoprotein particle oxidation

[Term]
id: GO:0034446
name: substrate adhesion-dependent cell spreading
namespace: biological_process
def: "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732]
synonym: "cell spreading during cell substrate adhesion" EXACT []
synonym: "substrate adhesion dependent cell spreading" EXACT []
is_a: GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0034447
name: very-low-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:rl]
synonym: "VLDL clearance" EXACT []
is_a: GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0034450
name: ubiquitin-ubiquitin ligase activity
namespace: molecular_function
def: "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
synonym: "E4" EXACT []
xref: Reactome:R-HSA-937050 "Pellino ubiquitinates hp-IRAK1"
xref: Reactome:R-HSA-975122 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>"
is_a: GO:0061630 ! ubiquitin protein ligase activity

[Term]
id: GO:0034451
name: centriolar satellite
namespace: cellular_component
def: "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0034452
name: dynactin binding
namespace: molecular_function
def: "Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0034453
name: microtubule anchoring
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0034454
name: microtubule anchoring at centrosome
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]
is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center

[Term]
id: GO:0034455
name: t-UTP complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:krc, GOC:mah, GOC:vw, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Nan1p-containing subcomplex of 90S preribosome" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0034456
name: UTP-C complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Rrp7p-containing subcomplex of 90S preribosome" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005730 ! nucleolus
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034457
name: Mpp10 complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005730 ! nucleolus
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034458
name: 3'-5' RNA helicase activity
namespace: molecular_function
alt_id: GO:0034459
def: "Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:jp]
synonym: "3' to 5' RNA helicase activity" EXACT []
synonym: "ATP-dependent 3' to 5' RNA helicase activity" EXACT []
synonym: "ATP-dependent 3'-5' RNA helicase activity" EXACT []
xref: EC:5.6.2.6
xref: Reactome:R-HSA-9836927 "SUPV3L1 unwinds double-stranded mitochondiral RNA"
is_a: GO:0003724 ! RNA helicase activity

[Term]
id: GO:0034460
name: uropod assembly
namespace: biological_process
def: "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane." [GOC:mah]
synonym: "uropod formation" EXACT [GOC:mah]
is_a: GO:0032796 ! uropod organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0034461
name: uropod retraction
namespace: biological_process
def: "The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell." [GOC:mah, PMID:10704379]
is_a: GO:0032796 ! uropod organization

[Term]
id: GO:0034462
name: small-subunit processome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah]
synonym: "small subunit processome assembly" EXACT []
synonym: "SSU processome assembly" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0180025 ! cytosolic small ribosomal subunit assembly

[Term]
id: GO:0034463
name: 90S preribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions." [GOC:krc, GOC:mah, GOC:tb]
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0042256 ! cytosolic ribosome assembly

[Term]
id: GO:0034464
name: BBSome
namespace: cellular_component
def: "A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B." [GOC:BHF, GOC:cilia, PMID:15231740, PMID:17574030, PMID:26498262]
synonym: "Bardet-Biedl syndrome complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0034465
name: response to carbon monoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034466
name: chromaffin granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a chromaffin granule." [GOC:rph]
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042583 ! chromaffin granule

[Term]
id: GO:0034467
name: esterosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an esterosome." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0033117 ! esterosome

[Term]
id: GO:0034468
name: glycosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a glycosome." [GOC:rph]
is_a: GO:0005782 ! peroxisomal matrix
relationship: part_of GO:0020015 ! glycosome

[Term]
id: GO:0034469
name: Golgi stack lumen
namespace: cellular_component
def: "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex." [GOC:mah]
is_a: GO:0005796 ! Golgi lumen
relationship: part_of GO:0005795 ! Golgi stack

[Term]
id: GO:0034470
name: obsolete ncRNA processing
namespace: biological_process
alt_id: GO:0031050
def: "OBSOLETE. Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah, PMID:27573892]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0006396

[Term]
id: GO:0034471
name: obsolete ncRNA 5'-end processing
namespace: biological_process
def: "OBSOLETE. Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0000966

[Term]
id: GO:0034472
name: snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
synonym: "snRNA 3' end processing" EXACT []
is_a: GO:0016180 ! snRNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0034473
name: U1 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U1 snRNA molecule." [GOC:mah]
synonym: "U1 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034474
name: U2 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah]
synonym: "U2 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034475
name: U4 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U4 snRNA molecule." [GOC:mah]
synonym: "U4 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034476
name: U5 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U5 snRNA molecule." [GOC:mah]
synonym: "U5 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034477
name: U6 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah]
synonym: "U6 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034478
name: phosphatidylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [GOC:mah]
synonym: "phosphatidylglycerol breakdown" EXACT []
synonym: "phosphatidylglycerol catabolism" EXACT []
synonym: "phosphatidylglycerol degradation" EXACT []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0034479
name: phosphatidylglycerol phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate." [GOC:mah, PMID:18434318]
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0034480
name: phosphatidylcholine phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine." [GOC:mah, RHEA:10604]
synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3]
synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3]
synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3]
synonym: "lipophosphodiesterase I activity" RELATED [EC:3.1.4.3]
synonym: "phosphatidylcholine cholinephosphohydrolase activity" RELATED []
synonym: "phospholipase C, acting on phosphatidylcholine" EXACT []
xref: EC:3.1.4.3
xref: MetaCyc:PHOSPHOLIPASE-C-RXN
xref: Reactome:R-HSA-9680388 "CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine"
xref: RHEA:10604
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0034481
name: chondroitin sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate." [GOC:curators]
is_a: GO:0050698 ! proteoglycan sulfotransferase activity

[Term]
id: GO:0034482
name: chondroitin 2-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues." [PMID:17227754]
synonym: "chondroitin 2-O-sulfotransferase activity" EXACT []
synonym: "chondroitin 2-O-sulphotransferase activity" EXACT []
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0034483
name: heparan sulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah]
is_a: GO:0050698 ! proteoglycan sulfotransferase activity

[Term]
id: GO:0034484
name: raffinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah]
synonym: "raffinose breakdown" EXACT []
synonym: "raffinose catabolism" EXACT []
synonym: "raffinose degradation" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0034485
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate." [EC:3.1.3.86, GOC:pf]
xref: EC:3.1.3.86
xref: MetaCyc:RXN-10036
xref: Reactome:R-HSA-1675949 "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane"
xref: RHEA:25528
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity

[Term]
id: GO:0034486
name: vacuolar transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034487
name: vacuolar amino acid transmembrane transport
namespace: biological_process
def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar amino acid membrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport

[Term]
id: GO:0034488
name: basic amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:0034487 ! vacuolar amino acid transmembrane transport
is_a: GO:1990822 ! basic amino acid transmembrane transport

[Term]
id: GO:0034489
name: neutral amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole

[Term]
id: GO:0034490
name: basic amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of basic amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:1990822 ! basic amino acid transmembrane transport

[Term]
id: GO:0034491
name: neutral amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole

[Term]
id: GO:0034492
name: hydrogenosome lumen
namespace: cellular_component
def: "The volume enclosed by the hydrogenosome membrane." [GOC:rph]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0042566 ! hydrogenosome

[Term]
id: GO:0034493
name: melanosome lumen
namespace: cellular_component
def: "The volume enclosed by the melanosome membrane." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0042470 ! melanosome

[Term]
id: GO:0034494
name: microneme lumen
namespace: cellular_component
def: "The volume enclosed by the microneme membrane." [GOC:rph]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0020009 ! microneme

[Term]
id: GO:0034495
name: protein storage vacuole lumen
namespace: cellular_component
def: "The volume enclosed by the protein storage vacuole membrane." [GOC:rph]
is_a: GO:0000330 ! plant-type vacuole lumen
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0034496
name: multivesicular body membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of multivesicular bodies." [GOC:rb]
synonym: "MVB membrane disassembly" EXACT []
is_a: GO:0030397 ! membrane disassembly
relationship: part_of GO:0036257 ! multivesicular body organization

[Term]
id: GO:0034497
name: protein localization to phagophore assembly site
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS)." [GOC:rb]
synonym: "protein localisation to phagophore assembly site" EXACT [GOC:mah]
synonym: "protein localization to PAS" EXACT []
synonym: "protein localization to pre-autophagosomal structure" NARROW []
is_a: GO:0008104 ! protein localization
relationship: part_of GO:0000045 ! autophagosome assembly

[Term]
id: GO:0034498
name: early endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from early endosomes to the Golgi." [GOC:rb]
synonym: "PGE to Golgi transport" EXACT []
synonym: "post-Golgi endosome to Golgi transport" EXACT []
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0034499
name: late endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from late endosomes to the Golgi." [GOC:rb]
synonym: "prevacuolar endosome to Golgi transport" EXACT []
synonym: "PVE to Golgi transport" EXACT []
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0034501
name: protein localization to kinetochore
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]
synonym: "condensin localization to kinetochore" NARROW []
synonym: "protein localisation to kinetochore" EXACT [GOC:mah]
is_a: GO:0071459 ! protein localization to chromosome, centromeric region
is_a: GO:1903083 ! protein localization to condensed chromosome

[Term]
id: GO:0034502
name: protein localization to chromosome
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah]
synonym: "condensin localization to chromosome" NARROW []
synonym: "protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0034503
name: protein localization to nucleolar rDNA repeats
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus." [GOC:mah]
synonym: "condensin localization to nucleolar rDNA repeats" NARROW []
synonym: "protein localisation to nucleolar rDNA repeats" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
relationship: part_of GO:0007000 ! nucleolus organization

[Term]
id: GO:0034504
name: protein localization to nucleus
namespace: biological_process
alt_id: GO:0044744
def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]
synonym: "protein localisation to nucleus" EXACT [GOC:mah]
synonym: "protein localization in cell nucleus" EXACT []
synonym: "protein localization in nucleus" EXACT [GOC:mah]
synonym: "protein targeting to nucleus" RELATED []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0034505
name: tooth mineralization
namespace: biological_process
def: "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum." [GOC:mah, MP:0002817, MSH:D014074]
synonym: "tooth calcification" EXACT []
is_a: GO:0031214 ! biomineral tissue development
relationship: part_of GO:0042476 ! odontogenesis

[Term]
id: GO:0034506
name: chromosome, centromeric core domain
namespace: cellular_component
def: "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw]
synonym: "chromosome, centric core region" RELATED []
synonym: "chromosome, centromeric core region" EXACT [GOC:vw]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0034508
name: centromere complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]
synonym: "centromere assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "centromere organization" EXACT [GOC:dph, PMID:18923422]
synonym: "chromosome, centromeric region assembly" EXACT [GOC:pr]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0065004 ! protein-DNA complex assembly

[Term]
id: GO:0034510
name: centromere separation
namespace: biological_process
def: "The cell cycle process in which centromeres are physically detached from each other during chromosome separation." [GOC:mah]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051304 ! chromosome separation
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0034511
name: U3 snoRNA binding
namespace: molecular_function
def: "Binding to a U3 small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034512
name: box C/D sno(s)RNA binding
namespace: molecular_function
def: "Binding to a box C/D small nucleolar RNA." [GOC:mah]
synonym: "box C/D snoRNA binding" NARROW []
synonym: "box C/D sRNA binding" NARROW []
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034513
name: box H/ACA snoRNA binding
namespace: molecular_function
def: "Binding to a box H/ACA small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034514
name: mitochondrial unfolded protein response
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004]
synonym: "mtUPR" EXACT []
is_a: GO:0034620 ! cellular response to unfolded protein

[Term]
id: GO:0034515
name: proteasome storage granule
namespace: cellular_component
def: "An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036]
synonym: "PSG" RELATED []
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034516
name: response to vitamin B6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah, GOC:rph]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034517
name: ribophagy
namespace: biological_process
def: "The selective degradation of mature ribosomes by macroautophagy." [GOC:autophagy, PMID:18391941]
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0034518
name: RNA cap binding complex
namespace: cellular_component
def: "A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation." [GOC:mah]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0034519
name: obsolete cytoplasmic RNA cap binding complex
namespace: cellular_component
def: "OBSOLETE. A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA." [PMID:16405910]
comment: This term was obsoleted because it represents the same complex as the eukaryotic translation initiation factor 4F complex ; GO:0016281.
is_obsolete: true
replaced_by: GO:0016281

[Term]
id: GO:0034520
name: obsolete 2-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+." [UM-BBD_reactionID:r0772]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034521
name: obsolete 1-naphthoic acid dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+." [UM-BBD_reactionID:r0773]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034522
name: obsolete cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034523
name: obsolete 3-formylsalicylate oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034524
name: obsolete 2-hydroxyisophthalate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034525
name: obsolete 1-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034526
name: obsolete 2-methylnaphthalene hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0788]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034527
name: obsolete 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034528
name: obsolete 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." [UM-BBD_reactionID:r0791]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034529
name: obsolete 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate." [PMID:7710320]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034530
name: obsolete 4-hydroxymethylsalicyaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+." [UM-BBD_reactionID:r0767]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034531
name: obsolete 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde." [PMID:8042906]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034532
name: obsolete 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate." [UM-BBD_reactionID:r0765]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034533
name: obsolete 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034534
name: obsolete 1-methylnaphthalene hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0795]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034535
name: obsolete 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034536
name: obsolete 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate." [UM-BBD_reactionID:r0782]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034537
name: obsolete 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde." [PMID:8042906]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034538
name: obsolete 3-methylsalicylaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034539
name: obsolete 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr." [UM-BBD_reactionID:r0821]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034540
name: obsolete 3-monobromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr." [UM-BBD_reactionID:r0824]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034541
name: obsolete dimethylarsinite methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034542
name: obsolete trimethylarsine oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O." [UM-BBD_reactionID:r0807]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034543
name: obsolete 5-aminosalicylate dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate." [UM-BBD_reactionID:r0809]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034544
name: obsolete trans-ACOHDA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3." [UM-BBD_reactionID:r0810]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034545
name: fumarylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811]
xref: EC:3.7.1.20
xref: RHEA:26168
xref: UM-BBD_reactionID:r0811
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034546
name: obsolete 2,4-dichloroaniline reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl." [UM-BBD_reactionID:r0819]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034547
name: N-cyclopropylmelamine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3." [UM-BBD_reactionID:r0825]
xref: MetaCyc:RXN-8018
xref: UM-BBD_reactionID:r0825
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034548
name: N-cyclopropylammeline deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3." [UM-BBD_reactionID:r0826]
xref: MetaCyc:RXN-8019
xref: UM-BBD_reactionID:r0826
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034549
name: N-cyclopropylammelide alkylamino hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid." [UM-BBD_reactionID:r0827]
xref: KEGG_REACTION:R06972
xref: MetaCyc:RXN-8020
xref: UM-BBD_reactionID:r0827
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034550
name: obsolete dimethylarsinate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O." [UM-BBD_reactionID:r0838]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034551
name: mitochondrial respiratory chain complex III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]
synonym: "mitochondrial cytochrome bc(1) complex assembly" EXACT [GOC:mcc]
is_a: GO:0017062 ! respiratory chain complex III assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly

[Term]
id: GO:0034552
name: respiratory chain complex II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." [GOC:dgf]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0034553
name: mitochondrial respiratory chain complex II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly
is_a: GO:0034552 ! respiratory chain complex II assembly

[Term]
id: GO:0034554
name: obsolete 3,3',5-tribromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr." [UM-BBD_reactionID:r0842]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034555
name: obsolete 3,3'-dibromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr." [UM-BBD_reactionID:r0844]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034556
name: obsolete nitrobenzoate nitroreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034557
name: 2-hydroxylaminobenzoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O." [MetaCyc:RXN-8848]
synonym: "o-hydroxylaminobenzoate nitroreductase activity" RELATED [UM-BBD_reactionID:r0850]
xref: MetaCyc:RXN-8848
xref: UM-BBD_reactionID:r0850
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0034558
name: obsolete technetium (VII) reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034559
name: obsolete bisphenol A hydroxylase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034560
name: obsolete bisphenol A hydroxylase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0861]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034561
name: obsolete 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034562
name: obsolete 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034563
name: obsolete 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034564
name: obsolete 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034565
name: obsolete 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol." [UM-BBD_reactionID:r0872]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034567
name: chromate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chromate = chromium (III)." [PMID:14766567, PMID:22558308, UM-BBD_reactionID:r0884]
xref: UM-BBD_reactionID:r0884
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034568
name: obsolete isoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0892]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034569
name: obsolete monodemethylisoproturon dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0893]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034570
name: obsolete hydroxymonomethylisoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0894]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034571
name: obsolete 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034572
name: obsolete monodemethylisoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." [UM-BBD_reactionID:r0897]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034573
name: obsolete didemethylisoproturon amidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034574
name: obsolete didemethylisoproturon dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0899]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034575
name: obsolete 4-isopropylaniline dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-." [UM-BBD_reactionID:r0901]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034576
name: obsolete N-isopropylacetanilide amidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034577
name: obsolete N-isopropylacetaniline monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone." [UM-BBD_reactionID:r0914]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034578
name: obsolete limonene 8-hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: limonene + H2O = alpha-terpineol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034579
name: obsolete (1-methylpentyl)succinate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034580
name: obsolete 4-methyloctanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0924]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034581
name: obsolete 4-methyloct-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034582
name: obsolete 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034583
name: 21U-RNA binding
namespace: molecular_function
def: "Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034584
name: piRNA binding
namespace: molecular_function
def: "Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
synonym: "Piwi-associated RNA binding" EXACT []
is_a: GO:0061980 ! regulatory RNA binding

[Term]
id: GO:0034585
name: 21U-RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
synonym: "21U-RNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0034586
name: 21U-RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
synonym: "21U-RNA breakdown" EXACT []
synonym: "21U-RNA catabolism" EXACT []
synonym: "21U-RNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0034585 ! 21U-RNA metabolic process

[Term]
id: GO:0034587
name: piRNA processing
namespace: biological_process
alt_id: GO:1990511
def: "A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]
subset: goslim_drosophila
synonym: "piRNA biogenesis" EXACT []
synonym: "piRNA biosynthetic process" RELATED []
synonym: "piRNA metabolic process" RELATED []
synonym: "piRNA metabolism" RELATED []
synonym: "PIWI-associated RNA biogenesis" EXACT []
synonym: "Piwi-associated RNA biosynthetic process" RELATED []
synonym: "Piwi-associated RNA metabolic process" RELATED []
synonym: "PIWI-associated RNA processing" EXACT []
is_a: GO:0070918 ! regulatory ncRNA processing

[Term]
id: GO:0034588
name: obsolete piRNA catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
comment: This term has been obsoleted because there is no evidence for a specific pathway for piRNA degradation.
synonym: "piRNA breakdown" EXACT []
synonym: "piRNA catabolism" EXACT []
synonym: "piRNA degradation" EXACT []
synonym: "Piwi-associated RNA catabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0034589
name: hydroxyproline transport
namespace: biological_process
def: "The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, PMID:14502423]
synonym: "4-hydroxyproline transport" EXACT []
synonym: "L-hydroxyproline transport" NARROW []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0034590
name: L-hydroxyproline transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-hydroxyproline from one side of a membrane to the other." [GOC:mah, PMID:14502423]
synonym: "4-hydroxyproline transmembrane transporter activity" BROAD []
xref: Reactome:R-HSA-6784213 "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0034591
name: rhoptry lumen
namespace: cellular_component
def: "The volume enclosed by the rhoptry membrane." [GOC:rph, PMID:17997128]
is_a: GO:0043233 ! organelle lumen
relationship: part_of GO:0020008 ! rhoptry

[Term]
id: GO:0034592
name: synaptic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph]
subset: goslim_synapse
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0034593
name: phosphatidylinositol bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]
synonym: "diphosphoinositide phosphatase activity" RELATED []
synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" EXACT []
synonym: "phosphatidylinositol-bisphosphatase activity" RELATED []
synonym: "triphosphoinositide phosphatase activity" RELATED []
synonym: "triphosphoinositide phosphomonoesterase activity" RELATED []
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034594
name: phosphatidylinositol trisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate." [GOC:mah]
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034595
name: phosphatidylinositol phosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate." [GOC:elh]
synonym: "phosphoinositide 5-phosphatase activity" EXACT []
synonym: "polyphosphoinositol lipid 5-phosphatase activity" EXACT []
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034596
name: phosphatidylinositol phosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah]
synonym: "inositol 4-phosphatase" NARROW [GOC:rl]
synonym: "phosphoinositide 4-phosphatase activity" EXACT []
synonym: "PI(4)P-phosphatase activity" EXACT [GOC:rl]
synonym: "PI4P-phosphatase activity" EXACT [GOC:rl]
synonym: "PtdIns4P-phosphatase activity" EXACT [GOC:rl]
xref: Reactome:R-HSA-1675988 "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane"
xref: Reactome:R-HSA-1676124 "PI4P is dephosphorylated to PI by SACM1L at the ER membrane"
xref: Reactome:R-HSA-1676133 "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane"
xref: Reactome:R-HSA-8849969 "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane"
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034597
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah, RHEA:25674]
synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT []
synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT []
xref: EC:3.1.3.78
xref: Reactome:R-HSA-6810410 "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus"
xref: RHEA:25674
is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity
is_a: GO:0106019 ! phosphatidylinositol-4,5-bisphosphate phosphatase activity

[Term]
id: GO:0034598
name: phosphothreonine lyase activity
namespace: molecular_function
def: "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product." [PMID:17303758, PMID:18084305]
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034599
name: cellular response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk]
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:0062197 ! cellular response to chemical stress

[Term]
id: GO:0034601
name: oxoglutarate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H." [GOC:curators]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034602
name: oxoglutarate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH." [GOC:mah, RHEA:27786]
xref: EC:1.2.1.105
xref: KEGG_REACTION:R08549
xref: MetaCyc:2OXOGLUTARATEDEH-RXN
xref: RHEA:27786
is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0034603
name: pyruvate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [GOC:mah]
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034604
name: pyruvate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH." [GOC:mah, ISBN:0201090910]
xref: EC:1.2.1.104
xref: KEGG_REACTION:R00209
xref: MetaCyc:PYRUVDEH-RXN
xref: RHEA:28042
is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0034605
name: cellular response to heat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
synonym: "cellular response to heat stress" EXACT []
is_a: GO:0009408 ! response to heat
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0034606
name: response to hermaphrodite contact
namespace: biological_process
def: "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [PMID:18050467, WB_REF:WBPaper00002109]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034607
name: turning behavior involved in mating
namespace: biological_process
def: "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [PMID:18050467, WB_REF:WBPaper00002109]
synonym: "turning behavior during mating" EXACT []
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034608
name: vulval location
namespace: biological_process
def: "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [PMID:18050467]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034609
name: spicule insertion
namespace: biological_process
def: "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [PMID:18050467]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034610
name: oligodeoxyribonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates." [GOC:mah]
synonym: "DNA oligonucleotidase activity" EXACT []
is_a: GO:0004536 ! DNA nuclease activity
is_a: GO:0008946 ! oligonucleotidase activity

[Term]
id: GO:0034611
name: oligoribonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates." [GOC:mah]
synonym: "RNA oligonucleotidase activity" EXACT []
xref: Reactome:R-HSA-9009950 "PDE12 cleaves 2'-5' oligoadenylates"
xref: Reactome:R-HSA-9615042 "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates"
is_a: GO:0004540 ! RNA nuclease activity
is_a: GO:0008946 ! oligonucleotidase activity

[Term]
id: GO:0034612
name: response to tumor necrosis factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]
synonym: "response to TNF" EXACT []
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0034614
name: cellular response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]
synonym: "cellular response to active oxygen species" EXACT []
synonym: "cellular response to AOS" EXACT []
synonym: "cellular response to reactive oxidative species" EXACT []
synonym: "cellular response to reactive oxygen intermediate" EXACT []
synonym: "cellular response to ROI" EXACT []
synonym: "cellular response to ROS" EXACT []
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0034615
name: GCH1 complex
namespace: cellular_component
def: "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive." [PMID:16696853]
synonym: "GTP cyclohydrolase I complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0034616
name: response to laminar fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." [GOC:ecd]
is_a: GO:0034405 ! response to fluid shear stress

[Term]
id: GO:0034617
name: tetrahydrobiopterin binding
namespace: molecular_function
def: "Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "BH4 binding" EXACT []
synonym: "H4biopterin binding" EXACT []
synonym: "sapropterin binding" EXACT []
xref: Reactome:R-HSA-1497784 "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle"
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0034618
name: arginine binding
namespace: molecular_function
def: "Binding to 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:BHF, GOC:rl]
synonym: "aminopentanoic acid binding" RELATED []
synonym: "Arg binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0034620
name: cellular response to unfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]
comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER.
synonym: "heat shock protein activity" RELATED []
is_a: GO:0006986 ! response to unfolded protein
is_a: GO:0035967 ! cellular response to topologically incorrect protein

[Term]
id: GO:0034624
name: obsolete DNA recombinase assembly involved in gene conversion at mating-type locus
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0034625
name: fatty acid elongation, monounsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which one C-C double bond has been introduced." [GOC:mah]
is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid

[Term]
id: GO:0034626
name: fatty acid elongation, polyunsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced." [GOC:mah]
is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid

[Term]
id: GO:0034627
name: 'de novo' NAD biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk, PMID:17161604]
synonym: "de novo NAD biosynthetic process" RELATED []
is_a: GO:0009435 ! NAD biosynthetic process

[Term]
id: GO:0034628
name: 'de novo' NAD biosynthetic process from aspartate
namespace: biological_process
alt_id: GO:0019355
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk]
synonym: "de novo NAD biosynthetic process from aspartate" RELATED []
synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT []
synonym: "nicotinamide nucleotide biosynthetic process from aspartate" EXACT []
synonym: "nicotinamide nucleotide formation from aspartate" EXACT []
synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0034627 ! 'de novo' NAD biosynthetic process

[Term]
id: GO:0034630
name: RITS complex localization
namespace: biological_process
def: "Any process in which a RITS complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of RITS complex localization" EXACT []
synonym: "RITS complex localisation" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0034631
name: microtubule anchoring at spindle pole body
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116]
synonym: "attachment of spindle microtubules to SPB" EXACT []
synonym: "attachment of spindle microtubules to spindle pole body" EXACT []
synonym: "microtubule anchoring at SPB" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center
relationship: part_of GO:0007051 ! spindle organization

[Term]
id: GO:0034632
name: retinol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "retinol transporter activity" RELATED []
synonym: "vitamin A1 transporter activity" EXACT []
xref: Reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport"
xref: Reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol"
xref: Reactome:R-HSA-2466802 "Defective ABCA4 does not transport NRPE from disc membranes"
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:0034633
name: retinol transport
namespace: biological_process
def: "The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "vitamin A1 transport" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0046865 ! terpenoid transport

[Term]
id: GO:0034634
name: glutathione transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other." [GOC:mah]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0042937 ! tripeptide transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0034635
name: glutathione transport
namespace: biological_process
def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0042939 ! tripeptide transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0034637
name: obsolete cellular carbohydrate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah]
comment: This term was obsoleted because it is not different from its parent, carbohydrate biosynthetic process ; GO:0016051.
is_obsolete: true
replaced_by: GO:0016051

[Term]
id: GO:0034638
name: phosphatidylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:jp]
synonym: "phosphatidylcholine breakdown" EXACT []
synonym: "phosphatidylcholine catabolism" EXACT []
synonym: "phosphatidylcholine degradation" EXACT []
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0034639
name: L-amino acid efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane." [GOC:mah]
synonym: "L-amino acid efflux permease activity" EXACT []
synonym: "L-amino acid export transporter activity" EXACT []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0034640
name: establishment of mitochondrion localization by microtubule attachment
namespace: biological_process
def: "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization." [GOC:mah, PMID:12972644]
synonym: "establishment of mitochondrion localisation by microtubule attachment" EXACT [GOC:mah]
synonym: "mitochondrial localization by microtubule attachment" EXACT []
synonym: "mitochondrial migration by microtubule attachment" EXACT []
synonym: "mitochondrion migration by microtubule attachment" EXACT []
is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated
is_a: GO:0099098 ! microtubule polymerization based movement

[Term]
id: GO:0034641
name: obsolete cellular nitrogen compound metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "cellular nitrogen compound metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0008152

[Term]
id: GO:0034642
name: mitochondrion migration along actin filament
namespace: biological_process
def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220]
synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb]
synonym: "mitochondrial migration along microfilament" EXACT []
synonym: "mitochondrial migration, actin-mediated" EXACT []
synonym: "mitochondrion migration along microfilament" EXACT []
synonym: "mitochondrion transport along actin filament" EXACT []
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0051654 ! establishment of mitochondrion localization
is_a: GO:0099515 ! actin filament-based transport

[Term]
id: GO:0034643
name: establishment of mitochondrion localization, microtubule-mediated
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220]
synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah]
synonym: "microtubule-mediated mitochondrion localization" EXACT []
synonym: "mitochondrial localization, microtubule-mediated" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0051654 ! establishment of mitochondrion localization

[Term]
id: GO:0034644
name: cellular response to UV
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]
synonym: "cellular response to ultraviolet light stimulus" EXACT []
synonym: "cellular response to ultraviolet radiation stimulus" EXACT []
synonym: "cellular response to UV light stimulus" EXACT []
synonym: "cellular response to UV radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0034645
name: obsolete cellular macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0034961
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [GOC:mah]
comment: This term was obsoleted because it is not different from its parent, macromolecule biosynthetic process ; GO:0009059.
synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule anabolism" EXACT [GOC:mah]
synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "cellular macromolecule formation" EXACT [GOC:mah]
synonym: "cellular macromolecule synthesis" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0009059

[Term]
id: GO:0034646
name: organelle-enclosing lipid monolayer
namespace: cellular_component
def: "A lipid monolayer that surrounds and encloses an organelle." [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0034647
name: histone H3K4me/H3K4me2/H3K4me3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17550896, PMID:22473470]
synonym: "H3K4me3 demethylase activity" RELATED []
synonym: "histone demethylase activity (H3-K4-me3 specific)" EXACT []
synonym: "histone demethylase activity (H3-trimethyl-K4 specific)" EXACT []
synonym: "histone H3-K4me2 demethylase activity" BROAD []
synonym: "histone H3-K4me3 demethylase activity" RELATED []
synonym: "histone H3-tri/di/monomethyl-lysine-4 demethylase activity" EXACT []
synonym: "histone H3K4me2 demethylase activity" BROAD []
xref: EC:1.14.11.67
xref: RHEA:60208
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0032453 ! histone H3K4 demethylase activity

[Term]
id: GO:0034648
name: obsolete histone demethylase activity (H3-dimethyl-K4 specific)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
comment: This term was obsoleted to align with RHEA and EC: this is a sub-reaction both in RHEA:60208 and EC:1.14.11.67.
synonym: "histone demethylase activity (H3-K4-me2 specific)" EXACT []
is_obsolete: true
consider: GO:0034647
consider: GO:0140682

[Term]
id: GO:0034649
name: obsolete histone demethylase activity (H3-monomethyl-K4 specific)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:16223729]
comment: This term was obsoleted to align with RHEA and EC: this is a sub-reaction both in RHEA:60208 and EC:1.14.11.67.
synonym: "histone demethylase activity (H3-K4-me1 specific)" EXACT []
is_obsolete: true
consider: GO:0034647
consider: GO:0140682

[Term]
id: GO:0034650
name: cortisol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "cortisol metabolism" EXACT []
is_a: GO:0008211 ! glucocorticoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0034651
name: cortisol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "cortisol anabolism" NARROW []
synonym: "cortisol biosynthesis" EXACT []
synonym: "cortisol formation" EXACT []
synonym: "cortisol synthesis" EXACT []
is_a: GO:0006704 ! glucocorticoid biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0034650 ! cortisol metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0034652
name: obsolete extrachromosomal circular DNA localization involved in cell aging
namespace: biological_process
def: "OBSOLETE. A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging." [GOC:dph, GOC:jp, GOC:tb, PMID:18660802]
comment: This term was obsoleted because it represents a phenotype.
synonym: "extrachromosomal circular DNA localisation involved in cell aging" EXACT [GOC:mah]
synonym: "extrachromosomal circular DNA localization during cell ageing" EXACT []
synonym: "extrachromosomal circular DNA localization during cell aging" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0034653
name: retinoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah]
synonym: "retinoic acid breakdown" EXACT []
synonym: "retinoic acid catabolism" EXACT []
synonym: "retinoic acid degradation" EXACT []
synonym: "vitamin A1 acid catabolic process" EXACT []
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:0042573 ! retinoic acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0034654
name: nucleobase-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0034655
name: nucleobase-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
subset: goslim_chembl
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0034656
name: nucleobase-containing small molecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah]
synonym: "nucleobase, nucleoside and nucleotide breakdown" EXACT []
synonym: "nucleobase, nucleoside and nucleotide catabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide degradation" EXACT []
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0034657
name: GID complex
namespace: cellular_component
def: "A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species." [PMID:12686616, PMID:18508925, PMID:35682545]
synonym: "C-terminal to LisH complex" EXACT [PMID:29911972]
synonym: "CTLH complex" EXACT [PMID:29911972]
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:0034658
name: isopropylmalate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of isopropylmalate from one side of a membrane to the other." [GOC:mah]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0034659
name: isopropylmalate transport
namespace: biological_process
def: "The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0034660
name: obsolete ncRNA metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "ncRNA metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0016070

[Term]
id: GO:0034661
name: obsolete ncRNA catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0006401

[Term]
id: GO:0034662
name: CFTR-NHERF-ezrin complex
namespace: cellular_component
def: "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity." [PMID:16129695, PMID:16798722, PMID:16926444]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0034663
name: endoplasmic reticulum chaperone complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]
synonym: "endoplasmic reticulum network complex" RELATED []
synonym: "ER chaperone complex" EXACT []
synonym: "ER network complex" RELATED []
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:0034664
name: Ig heavy chain-bound endoplasmic reticulum chaperone complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]
synonym: "Ig heavy chain-bound ER chaperone complex" EXACT []
synonym: "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex" EXACT []
is_a: GO:0101031 ! protein folding chaperone complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:0034665
name: integrin alpha1-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha1-beta1 integrin complex" EXACT []
synonym: "ITGA1-ITGB1 complex" NARROW []
synonym: "VLA-1 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034666
name: integrin alpha2-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha2 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA2-ITGB1 complex" NARROW [CORUM:2432]
synonym: "VLA-2 complex" EXACT [PMID:3546305]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034667
name: integrin alpha3-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha3-beta1 integrin complex" EXACT []
synonym: "ITGA3-ITGB1 complex" NARROW [CORUM:2406]
synonym: "VLA-3 complex" EXACT [PMID:3546305]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034668
name: integrin alpha4-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha4 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha4-beta1 integrin complex" EXACT []
synonym: "ITGA4-ITGB1 complex" NARROW []
synonym: "VLA-4 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034669
name: integrin alpha4-beta7 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha4 subunit and one beta7 subunit." [PMID:12297042]
synonym: "alpha4-beta7 integrin complex" EXACT []
synonym: "ITGA4-ITGB7 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034670
name: chemotaxis to arachidonate
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of arachidonic acid." [GOC:go_curators, PMID:18202452]
synonym: "chemotaxis to arachidonic acid" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0034671
name: obsolete retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros." [GOC:mh]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model.
synonym: "retinoic acid receptor signaling pathway involved in pronephric kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0034672
consider: GO:0048384

[Term]
id: GO:0034672
name: anterior/posterior pattern specification involved in pronephros development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah]
synonym: "anterior/posterior pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development

[Term]
id: GO:0034673
name: inhibin-betaglycan-ActRII complex
namespace: cellular_component
def: "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B." [GOC:BHF, PMID:10746731]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0034674
name: integrin alpha5-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha5-beta1 integrin complex" EXACT []
synonym: "ITGA5-ITGB1 complex" NARROW []
synonym: "VLA-5 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034675
name: integrin alpha6-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha6-beta1 integrin complex" EXACT []
synonym: "ITGA6-ITGB1 complex" NARROW [CORUM:2413]
synonym: "VLA-6 complex" EXACT [PMID:2649503]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034676
name: integrin alpha6-beta4 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha6 subunit and one beta4 subunit." [PMID:12297042]
synonym: "alpha6-beta4 integrin complex" EXACT []
synonym: "ITGA6-ITGB4 complex" NARROW [CORUM:2323]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034677
name: integrin alpha7-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha7-beta1 integrin complex" EXACT []
synonym: "ITGA7-ITGB1 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034678
name: integrin alpha8-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha8-beta1 integrin complex" EXACT []
synonym: "ITGA8-ITGB1 complex" NARROW [CORUM:2439]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034679
name: integrin alpha9-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha9-beta1 integrin complex" EXACT []
synonym: "ITGA9-ITGB1 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034680
name: integrin alpha10-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha10-beta1 integrin complex" EXACT []
synonym: "ITGA10-ITGB1 complex" NARROW [CORUM:3057]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034681
name: integrin alpha11-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha11-beta1 integrin complex" EXACT []
synonym: "ITGA11-ITGB1 complex" NARROW [CORUM:3058]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034682
name: integrin alphav-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042]
synonym: "alphav-beta1 integrin complex" EXACT []
synonym: "ITGAV-ITGB1 complex" NARROW [CORUM:2436]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034683
name: integrin alphav-beta3 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta3 subunit." [PMID:12297042]
synonym: "alphav-beta3 integrin complex" EXACT []
synonym: "ITGAV-ITGB3 complex" NARROW [CORUM:2816]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034684
name: integrin alphav-beta5 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta5 subunit." [PMID:12297042]
synonym: "alphav-beta5 integrin complex" EXACT []
synonym: "ITGAV-ITGB5 complex" NARROW [CORUM:2350]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034685
name: integrin alphav-beta6 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta6 subunit." [PMID:12297042]
synonym: "alphav-beta6 integrin complex" EXACT []
synonym: "ITGAV-ITGB6 complex" NARROW [CORUM:2354]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034686
name: integrin alphav-beta8 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta8 subunit." [PMID:12297042]
synonym: "alphav-beta8 integrin complex" EXACT []
synonym: "ITGAV-ITGB8 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034687
name: integrin alphaL-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaL subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaL-beta2 integrin complex" EXACT []
synonym: "Itgal-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034688
name: integrin alphaM-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaM subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaM-beta2 integrin complex" EXACT []
synonym: "Itgam-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034689
name: integrin alphaX-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaX subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaX-beta2 integrin complex" EXACT []
synonym: "Itgax-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034690
name: integrin alphaD-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaD subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaD-beta2 integrin complex" EXACT []
synonym: "Itgad-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034691
name: integrin alphaE-beta7 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaE subunit and one beta7 subunit." [PMID:12297042]
synonym: "Itgae-Itgb7 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034692
name: E.F.G complex
namespace: cellular_component
def: "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex." [PMID:8641291]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0034693
name: U11/U12 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077]
synonym: "18S U11/U12 snRNP" NARROW []
synonym: "snRNP U11/U12" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0034694
name: response to prostaglandin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0034695
name: response to prostaglandin E
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin E stimulus" EXACT [GOC:dos]
is_a: GO:0034694 ! response to prostaglandin
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0034696
name: response to prostaglandin F
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin F stimulus" EXACT [GOC:dos]
is_a: GO:0034694 ! response to prostaglandin

[Term]
id: GO:0034697
name: response to prostaglandin I
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin I stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0034694 ! response to prostaglandin
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034698
name: response to gonadotropin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:BHF, GOC:vk]
synonym: "response to gonadotropin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0034699
name: response to luteinizing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:BHF, GOC:vk]
synonym: "response to luteinizing hormone stimulus" EXACT [GOC:dos]
is_a: GO:0034698 ! response to gonadotropin
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0034700
name: allulose 6-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-allulose 6-phosphate = keto-D-fructose 6-phosphate." [RHEA:28426]
xref: MetaCyc:RXN0-304
xref: RHEA:28426
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0034701
name: tripeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a tripeptide." [GOC:mah]
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0034702
name: monoatomic ion channel complex
namespace: cellular_component
def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X]
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:0034703
name: cation channel complex
namespace: cellular_component
def: "An ion channel complex through which cations pass." [GOC:mah]
is_a: GO:0034702 ! monoatomic ion channel complex

[Term]
id: GO:0034704
name: calcium channel complex
namespace: cellular_component
def: "An ion channel complex through which calcium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034705
name: potassium channel complex
namespace: cellular_component
def: "An ion channel complex through which potassium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034706
name: sodium channel complex
namespace: cellular_component
def: "An ion channel complex through which sodium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034707
name: chloride channel complex
namespace: cellular_component
def: "An ion channel complex through which chloride ions pass." [GOC:mah]
is_a: GO:0034702 ! monoatomic ion channel complex

[Term]
id: GO:0034708
name: methyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses methyltransferase activity." [GOC:mah]
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0034709
name: methylosome
namespace: cellular_component
def: "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452]
synonym: "20S methylosome" EXACT []
synonym: "20S methyltransferase complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034710
name: inhibin complex binding
namespace: molecular_function
def: "Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit." [GOC:BHF, GOC:mah]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0034711
name: inhibin binding
namespace: molecular_function
alt_id: GO:0034712
alt_id: GO:0048186
alt_id: GO:0048187
def: "Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers." [GOC:BHF, GOC:mah]
synonym: "inhibin alpha binding" NARROW []
synonym: "inhibin beta-A binding" NARROW []
synonym: "inhibin beta-B binding" NARROW []
synonym: "inhibin monomer binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0034713
name: type I transforming growth factor beta receptor binding
namespace: molecular_function
alt_id: GO:0005103
alt_id: GO:0005116
alt_id: GO:0005120
def: "Binding to a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah]
synonym: "babo binding" NARROW []
synonym: "babo ligand" NARROW []
synonym: "baboon binding" NARROW []
synonym: "baboon ligand" NARROW []
synonym: "baboon receptor ligand" NARROW []
synonym: "sax binding" NARROW []
synonym: "sax ligand" NARROW []
synonym: "saxophone binding" NARROW []
synonym: "saxophone ligand" NARROW []
synonym: "TGF-beta type I binding" EXACT []
synonym: "thickveins binding" NARROW []
synonym: "thickveins ligand" NARROW []
synonym: "tkv binding" NARROW []
synonym: "tkv ligand" NARROW []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta receptor type I binding" EXACT []
synonym: "type I TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0034714
name: type III transforming growth factor beta receptor binding
namespace: molecular_function
def: "Binding to a type III transforming growth factor beta receptor." [GOC:BHF, GOC:mah]
synonym: "betaglycan binding" RELATED []
synonym: "TGF-beta type III binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED []
synonym: "transforming growth factor beta receptor type III binding" EXACT []
synonym: "type IIII TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0034715
name: pICln-Sm protein complex
namespace: cellular_component
def: "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266]
synonym: "6S pICln complex" EXACT []
is_a: GO:0120114 ! Sm-like protein family complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034716
name: Gemin3-Gemin4-Gemin5 complex
namespace: cellular_component
def: "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly." [GOC:mah, PMID:17640873]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0034717
name: Gemin6-Gemin7-unrip complex
namespace: cellular_component
def: "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly." [GOC:mah, PMID:17640873]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0034718
name: SMN-Gemin2 complex
namespace: cellular_component
def: "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
is_a: GO:0120114 ! Sm-like protein family complex

[Term]
id: GO:0034719
name: SMN-Sm protein complex
namespace: cellular_component
def: "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408]
comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797.
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0120114 ! Sm-like protein family complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034720
name: obsolete histone H3-K4 demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "H3K4 demethylation (me1 me2 and me3)" RELATED []
is_obsolete: true

[Term]
id: GO:0034721
name: obsolete histone H3-K4 demethylation, trimethyl-H3-K4-specific
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "H3K4 demethylation (me3)" EXACT []
synonym: "histone H3-K4 tridemethylation" RELATED []
is_obsolete: true

[Term]
id: GO:0034722
name: gamma-glutamyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26]
synonym: "gamma-glutamyl hydrolase activity" RELATED [EC:3.4.19.9]
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0034725
name: obsolete DNA replication-dependent nucleosome disassembly
namespace: biological_process
def: "OBSOLETE. The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629]
comment: This term was obsoleted because it did not describe a different process from that described by its parent.
synonym: "DNA replication-dependent chromatin disassembly" EXACT []
is_obsolete: true
consider: GO:0006337

[Term]
id: GO:0034726
name: obsolete DNA replication-independent nucleosome disassembly
namespace: biological_process
def: "OBSOLETE. The controlled disassembly of chromatin outside the context of DNA replication." [GOC:mah, PMID:17510629]
comment: This term was obsoleted because it did not describe a different process from that described by its parent.
synonym: "DNA replication-independent chromatin disassembly" RELATED []
is_obsolete: true

[Term]
id: GO:0034727
name: piecemeal microautophagy of the nucleus
namespace: biological_process
def: "Degradation of a cell nucleus by microautophagy." [GOC:autophagy, GOC:jp, PMID:18701704]
synonym: "PMN" EXACT []
is_a: GO:0016237 ! microautophagy
is_a: GO:0044804 ! nucleophagy

[Term]
id: GO:0034728
name: nucleosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah]
synonym: "nucleosome organisation" EXACT []
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0071824 ! protein-DNA complex organization

[Term]
id: GO:0034729
name: obsolete histone H3-K79 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [GOC:se]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K79 methylation" EXACT []
synonym: "histone H3K79me" EXACT []
synonym: "histone lysine H3 K79 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034730
name: SmD-containing SMN-Sm protein complex
namespace: cellular_component
def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408]
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0034719 ! SMN-Sm protein complex

[Term]
id: GO:0034731
name: Lsm-containing SMN-Sm protein complex
namespace: cellular_component
def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA." [PMID:12975319, PMID:17401408]
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0034719 ! SMN-Sm protein complex

[Term]
id: GO:0034732
name: transcription factor TFIIIB-alpha complex
namespace: cellular_component
def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." [PMID:11433012]
is_a: GO:0000126 ! transcription factor TFIIIB complex

[Term]
id: GO:0034733
name: transcription factor TFIIIB-beta complex
namespace: cellular_component
def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters." [PMID:11433012]
comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans.
is_a: GO:0000126 ! transcription factor TFIIIB complex

[Term]
id: GO:0034734
name: transcription factor TFIIIC1 complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity." [GOC:mah, PMID:11433012, PMID:15096501]
is_a: GO:0090576 ! RNA polymerase III transcription regulator complex
relationship: part_of GO:0000127 ! transcription factor TFIIIC complex

[Term]
id: GO:0034735
name: transcription factor TFIIIC2 complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter." [GOC:mah, PMID:11433012]
is_a: GO:0090576 ! RNA polymerase III transcription regulator complex
relationship: part_of GO:0000127 ! transcription factor TFIIIC complex

[Term]
id: GO:0034736
name: cholesterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA." [RHEA:17729]
synonym: "ACAT activity" BROAD [EC:2.3.1.26]
synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" RELATED [EC:2.3.1.26]
synonym: "acyl-CoA:cholesterol acyltransferase activity" RELATED [EC:2.3.1.26]
synonym: "acyl-CoA:cholesterol O-acyltransferase activity" RELATED [EC:2.3.1.26]
synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT []
synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26]
synonym: "cholesterol ester synthetase activity" RELATED [EC:2.3.1.26]
synonym: "cholesteryl ester synthetase activity" RELATED [EC:2.3.1.26]
xref: KEGG_REACTION:R01461
xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN
xref: Reactome:R-HSA-8876696 "SOAT1,2 transfer acyl group to CHOL forming CHEST"
xref: RHEA:17729
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034737
name: ergosterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [GOC:mah]
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034738
name: lanosterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [GOC:mah]
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034739
name: histone H4K16 deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [GOC:vw, PMID:28450737]
synonym: "histone deacetylase activity (H4-K16 specific)" EXACT []
synonym: "histone H4-K16 deacetylase activity" EXACT []
synonym: "histone H4K12 deacetylase activity" BROAD []
is_a: GO:0141051 ! histone H4K deacetylase activity

[Term]
id: GO:0034740
name: TFIIIC-TOP1-SUB1 complex
namespace: cellular_component
def: "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III." [PMID:9660958]
synonym: "TFIIIC-Topoisomerase 1-PC4 complex" EXACT []
is_a: GO:0090576 ! RNA polymerase III transcription regulator complex

[Term]
id: GO:0034741
name: APC-tubulin-IQGAP1 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization." [PMID:17126424]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "60S APC complex" NARROW []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1905360 ! GTPase complex

[Term]
id: GO:0034743
name: APC-IQGAP complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1905360 ! GTPase complex
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034744
name: APC-IQGAP1-Cdc42 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1905360 ! GTPase complex
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034745
name: APC-IQGAP1-Rac1 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1905360 ! GTPase complex
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034746
name: APC-IQGAP1-CLIP-170 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1905360 ! GTPase complex
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034748
name: Par3-APC-KIF3A complex
namespace: cellular_component
def: "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity." [PMID:15556865]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034749
name: Scrib-APC complex
namespace: cellular_component
def: "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation." [PMID:16611247]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "hScrib-APC complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034750
name: Scrib-APC-beta-catenin complex
namespace: cellular_component
def: "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "hScrib-APC-beta-catenin complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034751
name: aryl hydrocarbon receptor complex
namespace: cellular_component
def: "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]
synonym: "AhR complex" EXACT []
synonym: "AHRC" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0034752
name: cytosolic aryl hydrocarbon receptor complex
namespace: cellular_component
def: "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." [PMID:7598497, PMID:8937476, PMID:9447995]
synonym: "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex" RELATED []
synonym: "cytosolic AhR complex" EXACT []
synonym: "cytosolic AHRC" EXACT []
is_a: GO:0034751 ! aryl hydrocarbon receptor complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0034753
name: nuclear aryl hydrocarbon receptor complex
namespace: cellular_component
def: "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT)." [PMID:7598497]
synonym: "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex" RELATED []
synonym: "nuclear AhR complex" EXACT []
synonym: "nuclear AHRC" EXACT []
is_a: GO:0034751 ! aryl hydrocarbon receptor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0034755
name: iron ion transmembrane transport
namespace: biological_process
alt_id: GO:0000040
alt_id: GO:0006827
alt_id: GO:0061839
alt_id: GO:1903874
def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ferrous ion transmembrane transport" NARROW []
synonym: "ferrous iron transmembrane transport" NARROW []
synonym: "high affinity ferrous ion transmembrane transport" NARROW []
synonym: "high affinity iron ion transport" NARROW []
synonym: "high-affinity ferrous ion transmembrane transport" NARROW []
synonym: "high-affinity iron ion transmembrane transport" NARROW []
synonym: "high-affinity iron ion transport" NARROW []
synonym: "iron ion membrane transport" EXACT []
synonym: "iron(2+) transmembrane transport" NARROW []
synonym: "low affinity iron ion transport" NARROW []
synonym: "low-affinity iron ion transmembrane transport" NARROW []
synonym: "low-affinity iron ion transport" NARROW []
synonym: "transmembrane iron transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0034756
name: regulation of iron ion transport
namespace: biological_process
alt_id: GO:1900390
def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of Fe transport" EXACT []
synonym: "regulation of iron import" NARROW [GOC:TermGenie]
synonym: "regulation of iron ion import" NARROW []
synonym: "regulation of iron transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034757
name: negative regulation of iron ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of iron ion transport" EXACT []
synonym: "down-regulation of iron ion transport" EXACT []
synonym: "downregulation of iron ion transport" EXACT []
synonym: "inhibition of iron ion transport" NARROW []
synonym: "negative regulation of iron transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
relationship: negatively_regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034758
name: positive regulation of iron ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of iron ion transport" NARROW []
synonym: "positive regulation of iron transport" EXACT []
synonym: "stimulation of iron ion transport" NARROW []
synonym: "up regulation of iron ion transport" EXACT []
synonym: "up-regulation of iron ion transport" EXACT []
synonym: "upregulation of iron ion transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
relationship: positively_regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034759
name: regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of iron ion membrane transport" EXACT []
synonym: "regulation of transmembrane Fe transport" EXACT []
synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of transmembrane iron transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034760
name: negative regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of transmembrane iron ion transport" EXACT []
synonym: "down-regulation of transmembrane iron ion transport" EXACT []
synonym: "downregulation of transmembrane iron ion transport" EXACT []
synonym: "inhibition of transmembrane iron ion transport" NARROW []
synonym: "negative regulation of iron ion membrane transport" EXACT []
synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of transmembrane iron transport" EXACT []
is_a: GO:0034757 ! negative regulation of iron ion transport
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
relationship: negatively_regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034761
name: positive regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of transmembrane iron ion transport" NARROW []
synonym: "positive regulation of iron ion membrane transport" EXACT []
synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of transmembrane iron transport" EXACT []
synonym: "stimulation of transmembrane iron ion transport" NARROW []
synonym: "up regulation of transmembrane iron ion transport" EXACT []
synonym: "up-regulation of transmembrane iron ion transport" EXACT []
synonym: "upregulation of transmembrane iron ion transport" EXACT []
is_a: GO:0034758 ! positive regulation of iron ion transport
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
relationship: positively_regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034762
name: regulation of transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of membrane transport" EXACT []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034763
name: negative regulation of transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane transport" EXACT []
synonym: "down-regulation of transmembrane transport" EXACT []
synonym: "downregulation of transmembrane transport" EXACT []
synonym: "inhibition of transmembrane transport" NARROW []
synonym: "negative regulation of membrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034764
name: positive regulation of transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane transport" NARROW []
synonym: "positive regulation of membrane transport" EXACT []
synonym: "stimulation of transmembrane transport" NARROW []
synonym: "up regulation of transmembrane transport" EXACT []
synonym: "up-regulation of transmembrane transport" EXACT []
synonym: "upregulation of transmembrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034765
name: regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of ion membrane transport" EXACT []
synonym: "regulation of ion transmembrane transport" BROAD []
synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0043269 ! regulation of monoatomic ion transport
relationship: regulates GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0034766
name: negative regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane ion transport" EXACT []
synonym: "down-regulation of transmembrane ion transport" EXACT []
synonym: "downregulation of transmembrane ion transport" EXACT []
synonym: "inhibition of transmembrane ion transport" NARROW []
synonym: "negative regulation of ion membrane transport" EXACT []
synonym: "negative regulation of ion transmembrane transport" BROAD []
synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
relationship: negatively_regulates GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0034767
name: positive regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane ion transport" NARROW []
synonym: "positive regulation of ion membrane transport" EXACT []
synonym: "positive regulation of ion transmembrane transport" BROAD []
synonym: "positive regulation of transmembrane ion transport" EXACT []
synonym: "stimulation of transmembrane ion transport" NARROW []
synonym: "up regulation of transmembrane ion transport" EXACT []
synonym: "up-regulation of transmembrane ion transport" EXACT []
synonym: "upregulation of transmembrane ion transport" EXACT []
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
relationship: positively_regulates GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0034768
name: (E)-beta-ocimene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [EC:4.2.3.106, PMID:12624761]
xref: EC:4.2.3.106
xref: MetaCyc:RXN-5109
xref: RHEA:32691
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034769
name: basement membrane disassembly
namespace: biological_process
alt_id: GO:0060881
def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer.
synonym: "basal lamina disassembly" RELATED []
is_a: GO:0022617 ! extracellular matrix disassembly
is_a: GO:0071711 ! basement membrane organization

[Term]
id: GO:0034770
name: obsolete histone H4-K20 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 K20 methylation" EXACT []
synonym: "histone H4K20me" EXACT []
synonym: "histone lysine H4 K20 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034771
name: obsolete histone H4-K20 monomethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 K20 monomethylation" EXACT []
synonym: "histone lysine H4 K20 monomethylation" EXACT []
is_obsolete: true
consider: GO:0042799

[Term]
id: GO:0034772
name: obsolete histone H4-K20 dimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 K20 dimethylation" EXACT []
synonym: "histone lysine H4 K20 dimethylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034773
name: obsolete histone H4-K20 trimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 K20 trimethylation" EXACT []
synonym: "histone lysine H4 K20 trimethylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034774
name: secretory granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a secretory granule." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0034775
name: glutathione transmembrane transport
namespace: biological_process
def: "A process in which glutathione is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "glutathione membrane transport" EXACT []
synonym: "transmembrane glutathione transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034635 ! glutathione transport
is_a: GO:0035443 ! tripeptide transmembrane transport

[Term]
id: GO:0034776
name: response to histamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "response to histamine stimulus" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0034777
name: recycling endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a recycling endosome." [GOC:rph]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0055037 ! recycling endosome

[Term]
id: GO:0034778
name: obsolete 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034779
name: obsolete 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034780
name: obsolete glyphosate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034781
name: obsolete N-cyclohexylformamide amidohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034782
name: obsolete dimethylmalonate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034783
name: obsolete pivalate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034784
name: pivalyl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA." [RHEA:52620]
comment: Pivalyl-CoA is a synonym for 2,2-dimethylpropanoyl-CoA.
xref: MetaCyc:RXN-18585
xref: RHEA:52620
xref: UM-BBD_reactionID:r1033
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034785
name: salicylate 5-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034]
xref: EC:1.14.13.172
xref: MetaCyc:RXN-10446
xref: RHEA:35307
xref: UM-BBD_reactionID:r1034
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034786
name: obsolete 9-fluorenone-3,4-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034787
name: obsolete 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034788
name: obsolete 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034789
name: obsolete 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034790
name: obsolete 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034791
name: obsolete isobutylamine N-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O." [UM-BBD_reactionID:r1053]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034792
name: obsolete hypophosphite dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034793
name: obsolete cyclopropanecarboxylate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034794
name: obsolete cyclopropanecarboxyl-CoA decyclase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA." [UM-BBD_reactionID:r1057]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034795
name: obsolete cyclohexane monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O." [UM-BBD_reactionID:r1059]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "butane monooxygenase activity" RELATED []
synonym: "cyclohexane hydroxylase activity" EXACT [MetaCyc:RXN-8697]
is_obsolete: true

[Term]
id: GO:0034796
name: obsolete adipate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034797
name: obsolete fosfomycin 2-glutathione ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034798
name: obsolete fosfomycin 2-L-cysteine ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034799
name: obsolete dihydride TNP tautomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034800
name: obsolete trinitrophenol dihydride denitratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP." [UM-BBD_reactionID:r1067]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "2,4,6-trinitrophenol dihydride denitratase activity" EXACT []
synonym: "TNP dihydride denitratase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0034801
name: obsolete 2,4-dinitrocyclohexanone hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034802
name: obsolete branched-chain dodecylbenzene sulfonate monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite." [UM-BBD_reactionID:r1079]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034803
name: obsolete 3-hydroxy-2-naphthoate 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate." [UM-BBD_reactionID:r1104]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034804
name: obsolete benzo(a)pyrene 11,12-epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034805
name: obsolete benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034806
name: obsolete benzo(a)pyrene 11,12-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol." [UM-BBD_reactionID:r1124]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034807
name: obsolete 4,5-dihydroxybenzo(a)pyrene methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034808
name: obsolete benzo(a)pyrene 4,5-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol." [UM-BBD_reactionID:r1126]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034809
name: obsolete benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034810
name: obsolete 4,5-dihydroxybenzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate." [UM-BBD_reactionID:r1128]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034811
name: obsolete benzo(a)pyrene 9,10-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." [UM-BBD_reactionID:r1132]
comment: The reason for obsoletion is that this term represents a substrate-specific activity of a broad-specificity enzyme,
is_obsolete: true
replaced_by: GO:0070330

[Term]
id: GO:0034812
name: obsolete 9,10-dihydroxybenzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1134]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034813
name: obsolete benzo(a)pyrene 7,8-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol." [UM-BBD_reactionID:1137]
comment: The reason for obsoletion is that this term represents a substrate-specific activity of a broad-specificity enzyme,
is_obsolete: true
replaced_by: GO:0070330

[Term]
id: GO:0034814
name: obsolete 7,8-dihydroxy benzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1138]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034815
name: obsolete cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+." [UM-BBD_reactionID:r1135]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034816
name: obsolete anthracene 9,10-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034817
name: obsolete cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034818
name: obsolete ADD 9alpha-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin." [UM-BBD_reactionID:r1149]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034819
name: obsolete 3-HSA hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O." [UM-BBD_reactionID:r1150]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034820
name: obsolete 4,9-DSHA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034821
name: obsolete citronellol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034822
name: obsolete citronellal dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034823
name: citronellyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1157]
xref: KEGG_REACTION:R08088
xref: UM-BBD_reactionID:r1157
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034824
name: citronellyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+." [PMID:31964529]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034825
name: obsolete tetralin ring-hydroxylating dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+." [UM-BBD_reactionID:r1169]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034826
name: obsolete 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034827
name: obsolete 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+." [UM-BBD_reactionID:r1171]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034828
name: obsolete 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034829
name: obsolete 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034830
name: obsolete (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate." [UM-BBD_reactionID:r1174]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034831
name: obsolete (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034832
name: geranial dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E)-geranial + H2O + NAD+ = geranate + 2 H+ + NADH." [RHEA:34351]
xref: EC:1.2.1.86
xref: MetaCyc:RXN-11970
xref: RHEA:34351
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034833
name: obsolete geranylate CoA-transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034834
name: obsolete 2-mercaptobenzothiazole dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol." [UM-BBD_reactionID:r1177]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034835
name: obsolete 2-mercaptobenzothiazole monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1178]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034836
name: obsolete 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1181]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034837
name: obsolete 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034838
name: obsolete menthone dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034839
name: obsolete menth-2-enone hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034840
name: obsolete 3-hydroxymenthone dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034841
name: obsolete mentha-1,3-dione-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034842
name: obsolete thiophene-2-carboxylate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034843
name: obsolete 2-oxoglutaryl-CoA thioesterase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034844
name: obsolete naphthyl-2-methyl-succinate CoA-transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034845
name: obsolete naphthyl-2-methyl-succinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1258]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034846
name: obsolete naphthyl-2-methylene-succinyl-CoA lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034847
name: obsolete naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034848
name: obsolete naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034849
name: obsolete 2-naphthoate CoA-transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034850
name: obsolete isooctane monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol." [UM-BBD_reactionID:r1269]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034851
name: obsolete 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034852
name: obsolete 4,4-dimethyl-3-oxopentanal dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034853
name: obsolete 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034854
name: obsolete 4,4-dimethyl-3-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034855
name: obsolete 4-AD 9alpha-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O." [UM-BBD_reactionID:r1153]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034856
name: 2-hydroxyhexa-2,4-dienoate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate." [UM-BBD_reactionID:r1281]
xref: EC:4.2.1.132
xref: RHEA:32535
xref: UM-BBD_reactionID:r1281
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034857
name: obsolete 2-(methylthio)benzothiazole monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034858
name: obsolete 2-hydroxybenzothiazole monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034859
name: obsolete benzothiazole monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034860
name: obsolete 2-mercaptobenzothiazole desulfurase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor." [UM-BBD_reactionID:r1288]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034861
name: obsolete benzothiazole-2-sulfonate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-." [UM-BBD_reactionID:r1290]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034862
name: obsolete 2,6-dihydroxybenzothiazole monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034863
name: obsolete 2,4,4-trimethyl-1-pentanol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034864
name: obsolete 2,4,4-trimethylpentanal dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034865
name: obsolete 2,4,4-trimethylpentanoate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034866
name: obsolete 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034867
name: obsolete 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034868
name: obsolete 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034869
name: obsolete 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034870
name: obsolete pinacolone 5-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034871
name: obsolete 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034872
name: obsolete trans-geranyl-CoA isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA." [UM-BBD_reactionID:r1310]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034873
name: obsolete thioacetamide S-oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034874
name: obsolete thioacetamide S-oxide S-oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034875
name: caffeine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O." [RHEA:47148]
xref: EC:1.17.5.2
xref: RHEA:47148
xref: UM-BBD_reactionID:r1321
is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

[Term]
id: GO:0034876
name: obsolete isonicotinic acid hydrazide hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034877
name: obsolete isonicotinate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034878
name: obsolete 2-hydroxyisonicotinate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034879
name: obsolete 2,3,6-trihydroxyisonicotinate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034880
name: obsolete citrazinate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034881
name: obsolete citrazinate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: citrazinate + H2O = cis-aconitamide." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034882
name: obsolete cis-aconitamide amidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034883
name: obsolete isonicotinate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate." [UM-BBD_reactionID:r1347]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "isonicotinate reductase activity" EXACT []
is_obsolete: true
consider: GO:0016627

[Term]
id: GO:0034884
name: obsolete gamma-N-formylaminovinylacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1349]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "gamma-N-formylaminovinylacetaldehyde dehydrogenase activity" EXACT []
is_obsolete: true
consider: GO:0016903

[Term]
id: GO:0034885
name: obsolete gamma-N-formylaminovinylacetate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034886
name: obsolete gamma-aminovinylacetate deaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3." [UM-BBD_reactionID:r1351]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034887
name: obsolete 1,4-dihydroisonicotinate 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2." [UM-BBD_reactionID:r1348]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "1,4-dihydroisonicotinate 2,3-dioxygenase activity" EXACT []
is_obsolete: true
consider: GO:0016702

[Term]
id: GO:0034888
name: obsolete endosulfan monooxygenase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034889
name: obsolete endosulfan hemisulfate sulfatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034890
name: obsolete endosulfan diol hydrolyase (cyclizing) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034891
name: obsolete endosulfan diol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034892
name: obsolete endosulfan lactone lactonase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034893
name: obsolete N-nitrodimethylamine hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034894
name: obsolete 4-hydroxypyridine-3-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+." [UM-BBD_reactionID:r1397]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034895
name: obsolete pyridine-3,4-diol dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate." [UM-BBD_reactionID:r1398]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034896
name: obsolete 3-formiminopyruvate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." [UM-BBD_reactionID:r1400]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034897
name: obsolete 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034898
name: obsolete hexadecyltrimethylammonium chloride monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O." [UM-BBD_reactionID:r1373]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034899
name: trimethylamine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O." [EC:1.14.13.148, UM-BBD_reactionID:r1407]
xref: EC:1.14.13.148
xref: KEGG_REACTION:R05623
xref: RHEA:31979
xref: UM-BBD_reactionID:r1407
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034900
name: obsolete 3-(N-formyl)-formiminopyruvate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate." [UM-BBD_reactionID:r1399]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034901
name: obsolete endosulfan hydroxyether dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034902
name: obsolete endosulfan sulfate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034903
name: obsolete endosulfan ether monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034904
name: obsolete 5-chloro-2-oxopent-4-enoate hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034905
name: obsolete 5-chloro-4-hydroxy-2-oxopentanate aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde." [UM-BBD_reactionID:r1437]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034906
name: obsolete N-isopropylaniline 1,2-dixoxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine." [UM-BBD_reactionID:r0721]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034907
name: obsolete acetanilide 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide." [UM-BBD_reactionID:r0723]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034908
name: obsolete 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+." [UM-BBD_reactionID:r0724]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034909
name: 6-hydroxypseudooxynicotine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine." [UM-BBD_reactionID:r1441]
xref: EC:1.5.99.14
xref: RHEA:34223
xref: UM-BBD_reactionID:r1441
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034910
name: obsolete 6-hydroxy-3-succinoylpyridine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034911
name: obsolete phthalate 3,4-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+." [UM-BBD_reactionID:r1444]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034912
name: phthalate 3,4-cis-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+." [UM-BBD_reactionID:r1445]
xref: MetaCyc:RXN5F9-56
xref: UM-BBD_reactionID:r1445
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034914
name: obsolete trinitrophenol hydride denitratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP." [UM-BBD_reactionID:r1448]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "2,4,6-trinitrophenol hydride denitratase activity" EXACT []
synonym: "TNP hydride denitratase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0034915
name: obsolete 2-methylhexanoyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0927]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034916
name: obsolete 2-methylhexanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-." [UM-BBD_reactionID:r0928]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034917
name: obsolete 2-methylhex-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034918
name: obsolete 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034919
name: obsolete butyryl-CoA 2-C-propionyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034920
name: obsolete pyrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0934]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034921
name: obsolete cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034922
name: obsolete 4,5-dihydroxypyrene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+." [UM-BBD_reactionID:r0936]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034923
name: obsolete phenanthrene-4,5-dicarboxylate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034924
name: obsolete cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034925
name: obsolete pyrene 4,5-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034926
name: obsolete pyrene-4,5-epoxide hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034927
name: obsolete pyrene 1,2-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034928
name: obsolete 1-hydroxypyrene 6,7-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034929
name: obsolete 1-hydroxypyrene 7,8-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034930
name: obsolete 1-hydroxypyrene sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true
replaced_by: GO:0004062

[Term]
id: GO:0034931
name: obsolete 1-hydroxypyrene methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034932
name: obsolete 1-methoxypyrene 6,7-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034933
name: obsolete 1-hydroxy-6-methoxypyrene methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034934
name: obsolete phenanthrene-4-carboxylate dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate." [UM-BBD_reactionID:r0939]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034935
name: obsolete tetrachlorobenzene dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+." [UM-BBD_reactionID:r0957]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034936
name: obsolete 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+." [UM-BBD_reactionID:r0959]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034937
name: obsolete perchlorate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O." [UM-BBD_reactionID:r0980]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034938
name: pyrrole-2-carboxylate monooxygenase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD+." [RHEA:30351]
xref: EC:1.14.13.130
xref: RHEA:30351
xref: UM-BBD_reactionID:r0968
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034939
name: obsolete 5-hydroxypyrrole-2-carboxylate tautomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034940
name: obsolete 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034941
name: pyrrole-2-carboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2." [UM-BBD_reactionID:r0970]
xref: EC:4.1.1.93
xref: UM-BBD_reactionID:r0970
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034942
name: obsolete cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034943
name: obsolete trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034944
name: obsolete 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034945
name: obsolete 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r0987]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034946
name: obsolete 3-isopropylbut-3-enoyl-CoA thioesterase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034947
name: obsolete terephthalate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034948
name: obsolete 2,6-dihydroxypseudooxynicotine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate." [UM-BBD_reactionID:r0482]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034949
name: obsolete 1,1-dichloroethane reductive dehalogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl." [UM-BBD_reactionID:r1008]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034950
name: obsolete phenylboronic acid monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034951
name: obsolete o-hydroxylaminobenzoate mutase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate." [UM-BBD_reactionID:r1026]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034952
name: obsolete malonate semialdehyde decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034953
name: obsolete perillyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034954
name: obsolete diphenyl ether 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether." [UM-BBD_reactionID:r1450]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034955
name: obsolete 2,3-dihydroxydiphenyl ether dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol." [UM-BBD_reactionID:r1451]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034956
name: obsolete diphenyl ether 1,2-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+." [UM-BBD_reactionID:r1453]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034957
name: obsolete 3-nitrophenol nitroreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific reaction exists.
is_obsolete: true

[Term]
id: GO:0034958
name: obsolete aminohydroquinone monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3." [UM-BBD_reactionID:r1497]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0034959
name: endothelin maturation
namespace: biological_process
def: "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin." [GOC:BHF, GOC:rl]
is_a: GO:0016486 ! peptide hormone processing
relationship: part_of GO:0003100 ! regulation of systemic arterial blood pressure by endothelin

[Term]
id: GO:0034963
name: box C/D sno(s)RNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box C/D type small RNA transcript into a mature box C/D RNA." [GOC:krc, GOC:mah]
synonym: "box C/D snoRNA processing" NARROW []
synonym: "box C/D sRNA processing" NARROW []
is_a: GO:0033967 ! box C/D sno(s)RNA metabolic process
is_a: GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:0034964
name: box H/ACA sno(s)RNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box H/ACA type small RNA transcript into a mature box H/ACA RNA." [GOC:krc, GOC:mah]
synonym: "box H/ACA snoRNA processing" NARROW []
synonym: "box H/ACA sRNA processing" NARROW []
is_a: GO:0033979 ! box H/ACA sno(s)RNA metabolic process
is_a: GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:0034965
name: intronic box C/D snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA." [GOC:krc, GOC:mah]
is_a: GO:0031070 ! intronic snoRNA processing
is_a: GO:0034963 ! box C/D sno(s)RNA processing

[Term]
id: GO:0034966
name: intronic box H/ACA snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA." [GOC:mah]
is_a: GO:0031070 ! intronic snoRNA processing
is_a: GO:0034964 ! box H/ACA sno(s)RNA processing

[Term]
id: GO:0034967
name: Set3 complex
namespace: cellular_component
def: "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434]
synonym: "HDAC3 complex" EXACT []
synonym: "SET3C" EXACT []
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0034968
name: obsolete histone lysine methylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0034969
name: obsolete histone arginine methylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0034970
name: obsolete histone H3-R2 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 R2 methylation" EXACT []
synonym: "histone H3R2me" EXACT []
synonym: "histone lysine H3 R2 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034971
name: obsolete histone H3-R17 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 R17 methylation" EXACT []
synonym: "histone H3R17me" EXACT []
synonym: "histone lysine H3 R17 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034972
name: obsolete histone H3-R26 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 R26 methylation" EXACT []
synonym: "histone H3R26me" EXACT []
synonym: "histone lysine H3 R26 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0034973
name: Sid2-Mob1 complex
namespace: cellular_component
def: "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex." [GOC:vw, PMID:10837231, PMID:15060149]
synonym: "Dbf2p-Mob1p complex" EXACT []
synonym: "Sid2-Mob1 kinase complex" EXACT []
synonym: "Sid2p-Mob1p complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034974
name: Swi5-Swi2 complex
namespace: cellular_component
def: "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140]
comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p.
synonym: "Swi5 complex" BROAD []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0034975
name: protein folding in endoplasmic reticulum
namespace: biological_process
def: "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]
synonym: "oxidative protein folding" EXACT [PMID:25091901]
synonym: "protein folding in ER" EXACT []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0034976
name: response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]
synonym: "cellular response to endoplasmic reticulum stress" EXACT []
synonym: "ER stress response" EXACT []
synonym: "response to ER stress" EXACT []
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0034977
name: ABIN2-NFKB1-MAP3K8 complex
namespace: cellular_component
def: "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." [PMID:15169888]
synonym: "ABIN2-NFKB1-TPL-1 complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0034978
name: PDX1-PBX1b-MRG1 complex
namespace: cellular_component
def: "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes." [PMID:11279116, PMID:9710595]
synonym: "acinar cell-specific C complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0034979
name: NAD-dependent protein lysine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide." [GOC:BHF, GOC:mah, RHEA:43636]
synonym: "NAD(+)-dependent protein deacetylase" EXACT []
synonym: "NAD(+)-dependent protein deacylase" BROAD []
synonym: "NAD-dependent protein deacetylase activity" BROAD []
synonym: "protein acetyllysine N-acetyltransferase" BROAD []
synonym: "protein lysine deacetylase" BROAD []
synonym: "protein lysine deacylase" BROAD []
xref: EC:2.3.1.286
xref: Reactome:R-HSA-3371467 "SIRT1 deacetylates HSF1"
xref: Reactome:R-HSA-5211239 "SIRT1 deacetylates TAF1B in SL1 complex"
xref: Reactome:R-HSA-5685953 "SIRT6 deacetylates RBBP8"
xref: Reactome:R-HSA-5688289 "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2"
xref: Reactome:R-HSA-5688294 "SIRT5 deacetylates Cytochrome C"
xref: Reactome:R-HSA-9620532 "SIRT1,SIRT3 deacetylate FOXO3"
xref: Reactome:R-HSA-9667952 "ANKLE2 is deacetylated by SIRT2"
xref: Reactome:R-HSA-9854463 "SIRT3 deacetylates AcK-IDH2 dimer"
xref: RHEA:43636
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups
is_a: GO:0141218 ! NAD-dependent protein lysine deacylase activity

[Term]
id: GO:0034980
name: FHL2-CREB complex
namespace: cellular_component
def: "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation." [PMID:11046156]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0034981
name: FHL3-CREB complex
namespace: cellular_component
def: "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation." [PMID:11046156]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0034982
name: mitochondrial protein processing
namespace: biological_process
def: "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]
synonym: "mitochondrial protein modification" RELATED []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0034983
name: peptidyl-lysine deacetylation
namespace: biological_process
def: "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:BHF, GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "protein lysine acetylation" RELATED []
is_a: GO:0006476 ! protein deacetylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0034985
name: Ecsit-NDUFAF1 complex
namespace: cellular_component
def: "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed." [PMID:17344420]
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0034986
name: iron chaperone activity
namespace: molecular_function
def: "Directly binding to and delivering iron ions to a target protein." [GOC:BHF, GOC:vk]
xref: Reactome:R-HSA-9854405 "Frataxin transfers Fe2+ to ACO2"
xref: Reactome:R-HSA-9854984 "Transfer of Fe-S clusters to SDHB"
xref: Reactome:R-HSA-9866272 "2Fe-2S is inserted in UQCRFS1"
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0034987
name: immunoglobulin receptor binding
namespace: molecular_function
def: "Binding to one or more specific sites on an immunoglobulin receptor molecule." [GOC:BHF, GOC:vk]
synonym: "Fc receptor binding" RELATED []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0034988
name: Fc-gamma receptor I complex binding
namespace: molecular_function
def: "Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG." [GOC:BHF, GOC:vk]
is_a: GO:0034987 ! immunoglobulin receptor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0034992
name: microtubule organizing center attachment site
namespace: cellular_component
def: "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [GOC:mah, PMID:18692466]
comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
synonym: "MAS" EXACT []
synonym: "microtubule organising centre attachment site" EXACT []
synonym: "MTOC attachment site" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0034993
name: meiotic nuclear membrane microtubule tethering complex
namespace: cellular_component
def: "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis." [GOC:mah, PMID:18692466]
synonym: "LINC complex" EXACT []
synonym: "LInker of Nucleoskeleton and Cytoskeleton complex" EXACT []
synonym: "SUN-KASH complex" EXACT []
is_a: GO:0106094 ! nuclear membrane microtubule tethering complex
relationship: part_of GO:0034992 ! microtubule organizing center attachment site

[Term]
id: GO:0034994
name: microtubule organizing center attachment site organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches." [GOC:mah, PMID:18692466]
synonym: "MAS organization" EXACT []
synonym: "microtubule organising centre attachment site organisation" RELATED []
synonym: "MTOC attachment site organization" EXACT []
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0006998 ! nuclear envelope organization

[Term]
id: GO:0034995
name: SC5b-7 complex
namespace: cellular_component
def: "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly." [PMID:10090939]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0034996
name: RasGAP-Fyn-Lyn-Yes complex
namespace: cellular_component
def: "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." [PMID:1544885]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0034997
name: alphav-beta5 integrin-vitronectin complex
namespace: cellular_component
def: "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin." [PMID:1694173]
synonym: "ITGAV-ITGB5-VTN complex" NARROW [CORUM:3117]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0034998
name: obsolete oligosaccharyltransferase I complex
namespace: cellular_component
def: "OBSOLETE. An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887]
comment: The reason for obsoletion is that the meaning of the term is ambiguous and the data from the paper for which the term was requested can be accurately described using GO:0008250 oligosaccharyltransferase complex.
synonym: "OSTCI" EXACT []
is_obsolete: true
replaced_by: GO:0008250

[Term]
id: GO:0034999
name: obsolete oligosaccharyltransferase II complex
namespace: cellular_component
def: "OBSOLETE. An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes." [GOC:BHF, PMID:15835887]
comment: The reason for obsoletion is that the meaning of the term is ambiguous and the data from the paper for which the term was requested can be accurately described using GO:0008250 oligosaccharyltransferase complex.
synonym: "OSTCII" EXACT []
is_obsolete: true
replaced_by: GO:0008250

[Term]
id: GO:0035000
name: obsolete oligosaccharyltransferase III complex
namespace: cellular_component
def: "OBSOLETE. An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes." [PMID:15835887]
comment: The reason for obsoletion is that the meaning of the term is ambiguous and the data from the paper for which the term was requested can be accurately described using GO:0008250 oligosaccharyltransferase complex.
synonym: "OSTCIII" EXACT []
is_obsolete: true
replaced_by: GO:0008250

[Term]
id: GO:0035001
name: dorsal trunk growth, open tracheal system
namespace: biological_process
def: "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "dorsal trunk growth" RELATED []
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035002
name: liquid clearance, open tracheal system
namespace: biological_process
def: "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
synonym: "tracheal liquid clearance" EXACT []
is_a: GO:0042045 ! epithelial fluid transport
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035003
name: subapical complex
namespace: cellular_component
def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
synonym: "SAC" BROAD []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0035004
name: obsolete phosphatidylinositol 3-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "phosphoinositide 3-kinase activity" EXACT []
xref: Wikipedia:Phosphoinositide_3-kinase
is_obsolete: true
replaced_by: GO:0016303

[Term]
id: GO:0035005
name: 1-phosphatidylinositol-4-phosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + H+." [EC:2.7.1.154, RHEA:18373]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" RELATED [EC:2.7.1.154]
synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154]
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "phosphatidylinositol-4-phosphate 3-kinase activity" EXACT []
synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154]
xref: EC:2.7.1.154
xref: KEGG_REACTION:R05795
xref: MetaCyc:2.7.1.154-RXN
xref: Reactome:R-HSA-1675928 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane"
xref: Reactome:R-HSA-1676109 "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane"
xref: Reactome:R-HSA-1676206 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane"
xref: Reactome:R-HSA-8868072 "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2"
xref: RHEA:18373
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0035006
name: melanization defense response
namespace: biological_process
def: "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
synonym: "melanization defence response" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0035007
name: regulation of melanization defense response
namespace: biological_process
def: "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
synonym: "regulation of melanization defence response" EXACT []
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035008
name: positive regulation of melanization defense response
namespace: biological_process
def: "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]
synonym: "activation of melanization defense response" NARROW []
synonym: "positive regulation of melanization defence response" EXACT []
synonym: "stimulation of melanization defense response" NARROW []
synonym: "up regulation of melanization defense response" EXACT []
synonym: "up-regulation of melanization defense response" EXACT []
synonym: "upregulation of melanization defense response" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0035007 ! regulation of melanization defense response
is_a: GO:0045089 ! positive regulation of innate immune response
relationship: positively_regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035009
name: negative regulation of melanization defense response
namespace: biological_process
def: "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809]
synonym: "down regulation of melanization defense response" EXACT []
synonym: "down-regulation of melanization defense response" EXACT []
synonym: "downregulation of melanization defense response" EXACT []
synonym: "inhibition of melanization defense response" NARROW []
synonym: "negative regulation of melanization defence response" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0035007 ! regulation of melanization defense response
is_a: GO:0045824 ! negative regulation of innate immune response
relationship: negatively_regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035010
name: encapsulation of foreign target
namespace: biological_process
def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, PMID:11846478, PMID:12225920]
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0035011
name: melanotic encapsulation of foreign target
namespace: biological_process
def: "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
is_a: GO:0035006 ! melanization defense response
is_a: GO:0035010 ! encapsulation of foreign target

[Term]
id: GO:0035012
name: obsolete polytene chromosome, telomeric region
namespace: cellular_component
def: "OBSOLETE. The terminal region of a polytene chromosome." [GOC:bf]
comment: This term was obsoleted because it likely represents an assay for GO:0099115 chromosome, subtelomeric region.
is_obsolete: true

[Term]
id: GO:0035013
name: myosuppressin receptor activity
namespace: molecular_function
def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0035014
name: phosphatidylinositol 3-kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069]
comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
synonym: "phosphoinositide 3-kinase regulator activity" EXACT []
synonym: "PI3K regulator activity" EXACT []
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0035015
name: elongation of arista core
namespace: biological_process
def: "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0035016
name: elongation of arista lateral
namespace: biological_process
def: "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0035017
name: cuticle pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0035018
name: adult chitin-based cuticle pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "adult cuticle pattern formation" BROAD []
is_a: GO:0035017 ! cuticle pattern formation
relationship: part_of GO:0008365 ! adult chitin-based cuticle development

[Term]
id: GO:0035019
name: somatic stem cell population maintenance
namespace: biological_process
def: "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
is_a: GO:0019827 ! stem cell population maintenance

[Term]
id: GO:0035020
name: regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035021
name: negative regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
synonym: "down regulation of Rac protein signal transduction" EXACT []
synonym: "down-regulation of Rac protein signal transduction" EXACT []
synonym: "downregulation of Rac protein signal transduction" EXACT []
synonym: "inhibition of Rac protein signal transduction" NARROW []
is_a: GO:0035020 ! regulation of Rac protein signal transduction
is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction
relationship: negatively_regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035022
name: positive regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
synonym: "activation of Rac protein signal transduction" NARROW []
synonym: "stimulation of Rac protein signal transduction" NARROW []
synonym: "up regulation of Rac protein signal transduction" EXACT []
synonym: "up-regulation of Rac protein signal transduction" EXACT []
synonym: "upregulation of Rac protein signal transduction" EXACT []
is_a: GO:0035020 ! regulation of Rac protein signal transduction
is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction
relationship: positively_regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035023
name: regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035024
name: negative regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
synonym: "down regulation of Rho protein signal transduction" EXACT []
synonym: "down-regulation of Rho protein signal transduction" EXACT []
synonym: "downregulation of Rho protein signal transduction" EXACT []
synonym: "inhibition of Rho protein signal transduction" NARROW []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction
relationship: negatively_regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035025
name: positive regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
synonym: "activation of Rho protein signal transduction" NARROW []
synonym: "stimulation of Rho protein signal transduction" NARROW []
synonym: "up regulation of Rho protein signal transduction" EXACT []
synonym: "up-regulation of Rho protein signal transduction" EXACT []
synonym: "upregulation of Rho protein signal transduction" EXACT []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction
relationship: positively_regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035026
name: leading edge cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0035027
name: leading edge cell fate commitment
namespace: biological_process
def: "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet." [GOC:bf]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0035026 ! leading edge cell differentiation

[Term]
id: GO:0035028
name: leading edge cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0035027 ! leading edge cell fate commitment

[Term]
id: GO:0035029
name: dorsal closure, leading edge cell fate commitment
namespace: biological_process
def: "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis." [GOC:bf]
is_a: GO:0035027 ! leading edge cell fate commitment
relationship: part_of GO:0046663 ! dorsal closure, leading edge cell differentiation

[Term]
id: GO:0035032
name: phosphatidylinositol 3-kinase complex, class III
namespace: cellular_component
def: "A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069]
synonym: "class III PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class III" EXACT []
is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex

[Term]
id: GO:0035033
name: histone deacetylase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of histone deacetylase." [GOC:bf]
comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'.
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0035034
name: histone acetyltransferase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of histone acetyltransferase." [GOC:bf]
comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "histone acetylase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0035035
name: histone acetyltransferase binding
namespace: molecular_function
def: "Binding to an histone acetyltransferase." [GOC:bf]
synonym: "histone acetylase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035036
name: sperm-egg recognition
namespace: biological_process
def: "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf]
is_a: GO:0009988 ! cell-cell recognition
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035037
name: sperm entry
namespace: biological_process
def: "An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur." [GOC:bf, PMID:9630751]
is_a: GO:0006897 ! endocytosis
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035038
name: female pronucleus assembly
namespace: biological_process
def: "Assembly of the haploid nucleus of the unfertilized egg." [GOC:bf, ISBN:0582227089]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035039
name: male pronucleus assembly
namespace: biological_process
def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001]
synonym: "male pronucleus formation" RELATED [GOC:dph]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035040
name: sperm nuclear envelope removal
namespace: biological_process
def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001]
is_a: GO:0051081 ! nuclear membrane disassembly
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035041
name: sperm DNA decondensation
namespace: biological_process
def: "Unwinding of the condensed nuclear chromatin of an inactive male pronucleus after fertilization." [GOC:bf, PMID:11735001, PMID:23352575]
synonym: "sperm chromatin decondensation" EXACT []
is_a: GO:0006325 ! chromatin organization
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035042
name: obsolete fertilization, exchange of chromosomal proteins
namespace: biological_process
def: "OBSOLETE. Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001]
comment: This term has been obsoleted because it represents a molecular function (histone chaperone activity) and a process (sperm DNA decondensation).
synonym: "sperm-specific histone exchange" EXACT []
synonym: "sperm-specific histone replacement" EXACT []
is_obsolete: true
consider: GO:0035041
consider: GO:0140713

[Term]
id: GO:0035043
name: male pronuclear envelope synthesis
namespace: biological_process
def: "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation." [GOC:bf, PMID:11735001]
is_a: GO:0018985 ! pronuclear envelope synthesis
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035044
name: sperm aster formation
namespace: biological_process
def: "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035045
name: sperm plasma membrane disassembly
namespace: biological_process
def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238]
synonym: "sperm plasma membrane breakdown" EXACT []
synonym: "sperm plasma membrane catabolism" EXACT []
synonym: "sperm plasma membrane degradation" EXACT []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030397 ! membrane disassembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035046
name: pronuclear migration
namespace: biological_process
def: "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363]
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035047
name: centrosomal and pronuclear rotation
namespace: biological_process
def: "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion." [GOC:bf, ISBN:087969307X, PMID:10085292]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035048
name: obsolete splicing factor protein import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "splicing factor protein transport from cytoplasm to nucleus" EXACT []
synonym: "splicing factor protein-nucleus import" EXACT []
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0035049
name: obsolete juvenile hormone acid methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf]
comment: This term was obsoleted because it represents the same activity as farnesoic acid O-methyltransferase activity ; GO:0019010.
is_obsolete: true
replaced_by: GO:0019010

[Term]
id: GO:0035050
name: embryonic heart tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0007507 ! heart development
relationship: part_of GO:0048568 ! embryonic organ development

[Term]
id: GO:0035051
name: cardiocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
synonym: "cardiac cell differentiation" EXACT []
synonym: "heart cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0035052
name: dorsal vessel aortic cell fate commitment
namespace: biological_process
def: "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification

[Term]
id: GO:0035053
name: dorsal vessel heart proper cell fate commitment
namespace: biological_process
def: "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification

[Term]
id: GO:0035054
name: embryonic heart tube anterior/posterior pattern specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta." [GOC:bf, PMID:12435360]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0035059
name: RCAF complex
namespace: cellular_component
def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219]
synonym: "replication-coupling assembly factor complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0035060
name: brahma complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof." [GOC:bhm, PMID:10809665, PMID:12482982]
synonym: "BRM complex" EXACT []
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0035061
name: interchromatin granule
namespace: cellular_component
def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
synonym: "ICG" EXACT []
xref: NIF_Subcellular:sao1049471211
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0035062
name: omega speckle
namespace: cellular_component
def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
is_a: GO:0016607 ! nuclear speck

[Term]
id: GO:0035063
name: nuclear speck organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators]
comment: See also the cellular component term 'nuclear speck ; GO:0016607'.
synonym: "nuclear speck organisation" EXACT []
synonym: "nuclear speck organization and biogenesis" RELATED [GOC:mah]
synonym: "nuclear speckle assembly" NARROW [GOC:mah]
synonym: "nuclear speckle organization" EXACT []
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0035064
name: methylated histone binding
namespace: molecular_function
def: "Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]
is_a: GO:0042393 ! histone binding
is_a: GO:0140034 ! methylation-dependent protein binding

[Term]
id: GO:0035065
name: obsolete regulation of histone acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0035066
name: obsolete positive regulation of histone acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone acetylation" NARROW []
synonym: "stimulation of histone acetylation" NARROW []
synonym: "up regulation of histone acetylation" EXACT []
synonym: "up-regulation of histone acetylation" EXACT []
synonym: "upregulation of histone acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0035067
name: obsolete negative regulation of histone acetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone acetylation" EXACT []
synonym: "down-regulation of histone acetylation" EXACT []
synonym: "downregulation of histone acetylation" EXACT []
synonym: "inhibition of histone acetylation" NARROW []
is_obsolete: true

[Term]
id: GO:0035069
name: larval midgut histolysis
namespace: biological_process
def: "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683]
synonym: "larval midgut regression" EXACT []
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0035070
name: salivary gland histolysis
namespace: biological_process
def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683]
synonym: "salivary gland regression" EXACT []
is_a: GO:0007435 ! salivary gland morphogenesis
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0035071
name: obsolete salivary gland cell autophagic cell death
namespace: biological_process
def: "OBSOLETE. The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
comment: The reason for obsoletion is that this term was added in error.
is_obsolete: true

[Term]
id: GO:0035072
name: obsolete ecdysone-mediated induction of salivary gland cell autophagic cell death
namespace: biological_process
def: "OBSOLETE. Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf]
comment: The reason for obsoletion is that this term was added in error.
is_obsolete: true

[Term]
id: GO:0035073
name: pupariation
namespace: biological_process
def: "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
synonym: "puparium biosynthesis" EXACT []
synonym: "puparium formation" EXACT []
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0035210 ! prepupal development

[Term]
id: GO:0035074
name: pupation
namespace: biological_process
def: "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
synonym: "head eversion" EXACT []
synonym: "prepupal-pupal transition" EXACT []
xref: Wikipedia:Pupa
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0035209 ! pupal development

[Term]
id: GO:0035075
name: response to ecdysone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
is_a: GO:0036314 ! response to sterol
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0035076
name: ecdysone receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by an ecdysone binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf]
synonym: "ecdysone receptor-mediated signalling pathway" EXACT []
synonym: "nuclear receptor-mediated ecdysone signaling pathway" EXACT []
is_a: GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway
relationship: part_of GO:0071390 ! cellular response to ecdysone

[Term]
id: GO:0035077
name: ecdysone-mediated polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation." [GOC:bf, PMID:12543962]
is_a: GO:0035079 ! polytene chromosome puffing
relationship: part_of GO:0071390 ! cellular response to ecdysone

[Term]
id: GO:0035078
name: induction of programmed cell death by ecdysone
namespace: biological_process
def: "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf]
is_a: GO:0035081 ! induction of programmed cell death by hormones
relationship: part_of GO:0035075 ! response to ecdysone

[Term]
id: GO:0035079
name: polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0035080
name: heat shock-mediated polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962]
is_a: GO:0034605 ! cellular response to heat
is_a: GO:0035079 ! polytene chromosome puffing

[Term]
id: GO:0035081
name: induction of programmed cell death by hormones
namespace: biological_process
def: "Any process induced by hormones that directly activates any of the steps required for programmed cell death." [GOC:bf]
is_a: GO:0012502 ! induction of programmed cell death

[Term]
id: GO:0035082
name: axoneme assembly
namespace: biological_process
alt_id: GO:0035083
alt_id: GO:0035084
def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "axoneme biogenesis" RELATED [GOC:mah]
synonym: "ciliary axoneme assembly" EXACT []
synonym: "cilium axoneme assembly" EXACT []
synonym: "cilium axoneme biogenesis" RELATED [GOC:mah]
synonym: "flagellar axoneme assembly" EXACT []
synonym: "flagellum axoneme assembly" EXACT []
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0060271 ! cilium assembly

[Term]
id: GO:0035088
name: establishment or maintenance of apical/basal cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity

[Term]
id: GO:0035089
name: establishment of apical/basal cell polarity
namespace: biological_process
def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf]
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity
is_a: GO:0061162 ! establishment of monopolar cell polarity

[Term]
id: GO:0035090
name: maintenance of apical/basal cell polarity
namespace: biological_process
def: "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf]
is_a: GO:0030011 ! maintenance of cell polarity
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity

[Term]
id: GO:0035091
name: phosphatidylinositol binding
namespace: molecular_function
def: "Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
synonym: "phosphoinositide binding" EXACT []
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0035092
name: sperm DNA condensation
namespace: biological_process
alt_id: GO:0035093
def: "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001]
synonym: "sperm chromatin condensation" EXACT []
synonym: "spermatogenesis, exchange of chromosomal proteins" RELATED []
is_a: GO:0006325 ! chromatin organization
relationship: part_of GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0035094
name: response to nicotine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0035095
name: behavioral response to nicotine
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732]
synonym: "behavioural response to nicotine" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0035094 ! response to nicotine

[Term]
id: GO:0035096
name: larval midgut cell programmed cell death
namespace: biological_process
def: "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ." [GOC:bf, GOC:mtg_apoptosis]
synonym: "larval midgut cell death" EXACT []
synonym: "programmed cell death of larval midgut cells" EXACT []
is_a: GO:0010623 ! programmed cell death involved in cell development
relationship: part_of GO:0035069 ! larval midgut histolysis

[Term]
id: GO:0035097
name: histone methyltransferase complex
namespace: cellular_component
def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]
subset: goslim_pir
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0035098
name: ESC/E(Z) complex
namespace: cellular_component
def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:krc, GOC:sp, PMID:12408863, PMID:12408864, PMID:17107999, PMID:20064375, PMID:31123059, PMID:33232890]
synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT []
synonym: "polycomb repressive complex 2" EXACT []
synonym: "PRC2 complex" EXACT [GOC:sp, PMID:20064375]
is_a: GO:0031519 ! PcG protein complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0035099
name: hemocyte migration
namespace: biological_process
def: "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
synonym: "arthropod blood cell migration" EXACT []
synonym: "hemocyte cell migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0035100
name: ecdysone binding
namespace: molecular_function
def: "Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732, ISBN:0582227089]
is_a: GO:0032934 ! sterol binding
is_a: GO:0042562 ! hormone binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0035101
name: FACT complex
namespace: cellular_component
def: "A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage." [PMID:12934006, PMID:12934007, PMID:16678108, PMID:34731638]
synonym: "Facilitates chromatin transcription complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0035102
name: PRC1 complex
namespace: cellular_component
def: "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]
comment: In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.
synonym: "Polycomb repressive complex 1" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0031519 ! PcG protein complex

[Term]
id: GO:0035103
name: obsolete sterol regulatory element binding protein cleavage
namespace: biological_process
alt_id: GO:0006992
def: "OBSOLETE. The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525]
comment: This term was obsoleted because it represents a molecular function.
synonym: "SREBP cleavage" EXACT []
synonym: "sterol depletion response, SREBP cleavage" EXACT []
synonym: "sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway" NARROW [GOC:vw]
is_obsolete: true

[Term]
id: GO:0035105
name: obsolete sterol regulatory element binding protein import into nucleus
namespace: biological_process
alt_id: GO:0006993
def: "OBSOLETE. The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, GOC:vw, PMID:12923525]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "SREBP import into nucleus" EXACT [GOC:mah]
synonym: "SREBP import into nucleus involved in sterol depletion response" EXACT [GOC:mah]
synonym: "SREBP nuclear translocation" NARROW [GOC:mah]
synonym: "sterol depletion response, SREBP import into nucleus" EXACT [GOC:mah]
synonym: "sterol depletion response, SREBP nuclear translocation" NARROW [GOC:mah]
synonym: "sterol depletion response, sterol regulatory element binding protein import into nucleus" EXACT []
synonym: "sterol depletion response, sterol regulatory element binding protein nuclear translocation" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "sterol regulatory element binding protein import into nucleus involved in sterol depletion response" NARROW [GOC:vw]
synonym: "sterol regulatory element binding protein nuclear translocation" NARROW [GOC:mah]
synonym: "sterol regulatory element binding protein nuclear translocation involved in sterol depletion response" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0006606
consider: GO:0042306

[Term]
id: GO:0035106
name: operant conditioning
namespace: biological_process
def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373]
synonym: "instrumental conditioning" EXACT []
xref: Wikipedia:Operant_conditioning
is_a: GO:0007612 ! learning

[Term]
id: GO:0035107
name: appendage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048736 ! appendage development

[Term]
id: GO:0035108
name: limb morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping." [UBERON:0002101]
synonym: "limb bud morphogenesis" NARROW [GOC:dph]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0060173 ! limb development

[Term]
id: GO:0035109
name: obsolete imaginal disc-derived limb morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
comment: This term was made obsolete because the term 'limb' is not widely used in the insect community. In GO, 'limb' is used to describe the vertebrate hindlimbs and forelimbs.
synonym: "imaginal disc-derived limb morphogenesis" EXACT []
is_obsolete: true
consider: GO:0035114

[Term]
id: GO:0035110
name: obsolete leg morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of a leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf, ISBN:0198612001]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "leg morphogenesis" EXACT []
is_obsolete: true
consider: GO:0007480
consider: GO:0035108
consider: GO:0035137

[Term]
id: GO:0035111
name: obsolete leg joint morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur." [GOC:bf, ISBN:0582227089, PMID:12051824]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "leg joint morphogenesis" EXACT []
is_obsolete: true
consider: GO:0016348
consider: GO:0036023

[Term]
id: GO:0035112
name: genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf]
synonym: "genital morphogenesis" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0048806 ! genitalia development

[Term]
id: GO:0035113
name: embryonic appendage morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0035107 ! appendage morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0035114
name: imaginal disc-derived appendage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:mtg_sensu, ISBN:0582227089]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0048737 ! imaginal disc-derived appendage development

[Term]
id: GO:0035115
name: embryonic forelimb morphogenesis
namespace: biological_process
alt_id: GO:0035117
def: "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [ISBN:0198612001]
synonym: "embryonic arm morphogenesis" NARROW [GOC:bf, GOC:cjm]
is_a: GO:0030326 ! embryonic limb morphogenesis
is_a: GO:0035136 ! forelimb morphogenesis

[Term]
id: GO:0035116
name: embryonic hindlimb morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal." [ISBN:0198612001]
is_a: GO:0030326 ! embryonic limb morphogenesis
is_a: GO:0035137 ! hindlimb morphogenesis

[Term]
id: GO:0035118
name: embryonic pectoral fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035113 ! embryonic appendage morphogenesis
is_a: GO:0035138 ! pectoral fin morphogenesis

[Term]
id: GO:0035119
name: embryonic pelvic fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035113 ! embryonic appendage morphogenesis
is_a: GO:0035139 ! pelvic fin morphogenesis

[Term]
id: GO:0035120
name: post-embryonic appendage morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0035107 ! appendage morphogenesis

[Term]
id: GO:0035121
name: obsolete tail morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of the tail are generated and organized. The tail is the hindmost part of some animals." [ISBN:0198612001]
comment: This term was made obsolete because 'tail' has different meanings in different organisms, and is therefore not a useful grouping term.
synonym: "tail morphogenesis" EXACT []
is_obsolete: true
consider: GO:0003002
consider: GO:0036342
consider: GO:0048809

[Term]
id: GO:0035122
name: embryonic medial fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "embryonic unpaired fin morphogenesis" EXACT []
is_a: GO:0035113 ! embryonic appendage morphogenesis
is_a: GO:0035141 ! medial fin morphogenesis

[Term]
id: GO:0035123
name: embryonic dorsal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035142 ! dorsal fin morphogenesis

[Term]
id: GO:0035124
name: embryonic caudal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035143 ! caudal fin morphogenesis

[Term]
id: GO:0035125
name: embryonic anal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035144 ! anal fin morphogenesis

[Term]
id: GO:0035126
name: post-embryonic genitalia morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf]
synonym: "post-embryonic genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis

[Term]
id: GO:0035127
name: post-embryonic limb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [ISBN:0395825172]
is_a: GO:0035108 ! limb morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis

[Term]
id: GO:0035128
name: post-embryonic forelimb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism." [GOC:bf]
is_a: GO:0035127 ! post-embryonic limb morphogenesis
is_a: GO:0035136 ! forelimb morphogenesis

[Term]
id: GO:0035129
name: post-embryonic hindlimb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized." [GOC:bf]
is_a: GO:0035127 ! post-embryonic limb morphogenesis
is_a: GO:0035137 ! hindlimb morphogenesis

[Term]
id: GO:0035130
name: post-embryonic pectoral fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
is_a: GO:0035138 ! pectoral fin morphogenesis

[Term]
id: GO:0035131
name: post-embryonic pelvic fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
is_a: GO:0035139 ! pelvic fin morphogenesis

[Term]
id: GO:0035132
name: post-embryonic medial fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "post-embryonic unpaired fin morphogenesis" EXACT []
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
is_a: GO:0035141 ! medial fin morphogenesis

[Term]
id: GO:0035133
name: post-embryonic caudal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035143 ! caudal fin morphogenesis

[Term]
id: GO:0035134
name: post-embryonic dorsal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035142 ! dorsal fin morphogenesis

[Term]
id: GO:0035135
name: post-embryonic anal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035144 ! anal fin morphogenesis

[Term]
id: GO:0035136
name: forelimb morphogenesis
namespace: biological_process
alt_id: GO:0035140
def: "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [GOC:go_curators]
synonym: "arm morphogenesis" NARROW [GOC:bf, GOC:cjm]
is_a: GO:0035108 ! limb morphogenesis

[Term]
id: GO:0035137
name: hindlimb morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindlimb are generated and organized." [GOC:go_curators]
is_a: GO:0035108 ! limb morphogenesis

[Term]
id: GO:0035138
name: pectoral fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0033334 ! fin morphogenesis
relationship: part_of GO:0033339 ! pectoral fin development

[Term]
id: GO:0035139
name: pelvic fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0033334 ! fin morphogenesis
relationship: part_of GO:0033340 ! pelvic fin development

[Term]
id: GO:0035141
name: medial fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "median fin morphogenesis" EXACT []
synonym: "unpaired fin morphogenesis" EXACT []
is_a: GO:0033334 ! fin morphogenesis
relationship: part_of GO:0033338 ! medial fin development

[Term]
id: GO:0035142
name: dorsal fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033337 ! dorsal fin development

[Term]
id: GO:0035143
name: caudal fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033336 ! caudal fin development

[Term]
id: GO:0035144
name: anal fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033335 ! anal fin development

[Term]
id: GO:0035145
name: exon-exon junction complex
namespace: cellular_component
def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]
synonym: "EJC" EXACT []
synonym: "exon junction complex" EXACT [GOC:dph]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0035146
name: tube fusion
namespace: biological_process
def: "The joining of specific branches of a tubular system to form a continuous network." [GOC:bf]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0048754 ! branching morphogenesis of an epithelial tube

[Term]
id: GO:0035147
name: branch fusion, open tracheal system
namespace: biological_process
def: "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
synonym: "tracheal branch fusion" EXACT []
is_a: GO:0035146 ! tube fusion
relationship: part_of GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0035148
name: tube formation
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]
synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah]
synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035239 ! tube morphogenesis

[Term]
id: GO:0035149
name: lumen formation, open tracheal system
namespace: biological_process
def: "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
synonym: "tracheal lumen formation" EXACT []
is_a: GO:0035148 ! tube formation
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035150
name: regulation of tube size
namespace: biological_process
def: "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes." [PMID:10887083]
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0035151
name: regulation of tube size, open tracheal system
namespace: biological_process
def: "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
synonym: "regulation of tracheal tube size" EXACT []
is_a: GO:0035150 ! regulation of tube size
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035152
name: regulation of tube architecture, open tracheal system
namespace: biological_process
def: "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
synonym: "regulation of tracheal tube architecture" EXACT []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035153
name: epithelial cell type specification, open tracheal system
namespace: biological_process
def: "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
synonym: "tracheal cell type specification" BROAD []
synonym: "tracheal epithelial cell type specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035154
name: terminal cell fate specification, open tracheal system
namespace: biological_process
def: "The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
synonym: "terminal cell fate specification" EXACT []
is_a: GO:0035153 ! epithelial cell type specification, open tracheal system

[Term]
id: GO:0035155
name: negative regulation of terminal cell fate specification, open tracheal system
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581]
synonym: "down regulation of terminal cell fate specification" EXACT []
synonym: "down-regulation of terminal cell fate specification" EXACT []
synonym: "downregulation of terminal cell fate specification" EXACT []
synonym: "inhibition of terminal cell fate specification" NARROW []
synonym: "negative regulation of terminal cell fate specification" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system

[Term]
id: GO:0035156
name: fusion cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion." [PMID:11063940]
is_a: GO:0035153 ! epithelial cell type specification, open tracheal system

[Term]
id: GO:0035157
name: negative regulation of fusion cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581]
synonym: "down regulation of fusion cell fate specification" EXACT []
synonym: "down-regulation of fusion cell fate specification" EXACT []
synonym: "downregulation of fusion cell fate specification" EXACT []
synonym: "inhibition of fusion cell fate specification" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0035156 ! fusion cell fate specification

[Term]
id: GO:0035158
name: regulation of tube diameter, open tracheal system
namespace: biological_process
def: "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
synonym: "regulation of tracheal tube diameter" EXACT []
synonym: "tracheal tube dilation" NARROW []
synonym: "tracheal tube expansion" NARROW []
is_a: GO:0035151 ! regulation of tube size, open tracheal system
is_a: GO:0035296 ! regulation of tube diameter

[Term]
id: GO:0035159
name: regulation of tube length, open tracheal system
namespace: biological_process
def: "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
synonym: "regulation of tracheal tube length" EXACT []
synonym: "tracheal tube elongation" NARROW []
is_a: GO:0035151 ! regulation of tube size, open tracheal system

[Term]
id: GO:0035160
name: maintenance of epithelial integrity, open tracheal system
namespace: biological_process
def: "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183]
synonym: "maintenance of tracheal epithelial integrity" EXACT []
is_a: GO:0010669 ! epithelial structure maintenance
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035161
name: imaginal disc lineage restriction
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0007447 ! imaginal disc pattern formation

[Term]
id: GO:0035162
name: embryonic hemopoiesis
namespace: biological_process
def: "The stages of blood cell formation that take place within the embryo." [GOC:bf]
synonym: "embryonic haematopoiesis" EXACT []
synonym: "embryonic haemopoiesis" EXACT []
synonym: "embryonic hematopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0035163
name: embryonic hemocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
synonym: "embryonic arthropod blood cell differentiation" EXACT []
synonym: "embryonic hemocyte cell differentiation" EXACT []
is_a: GO:0042386 ! hemocyte differentiation
relationship: part_of GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0035164
name: embryonic plasmatocyte differentiation
namespace: biological_process
def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791]
synonym: "embryonic plasmatocyte cell differentiation" EXACT []
is_a: GO:0035163 ! embryonic hemocyte differentiation
is_a: GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0035165
name: embryonic crystal cell differentiation
namespace: biological_process
def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0035163 ! embryonic hemocyte differentiation
is_a: GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0035166
name: post-embryonic hemopoiesis
namespace: biological_process
def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf]
synonym: "post-embryonic haemopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0035167
name: larval lymph gland hemopoiesis
namespace: biological_process
def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
synonym: "larval lymph gland haematopoiesis" EXACT []
synonym: "larval lymph gland haemopoiesis" EXACT []
synonym: "larval lymph gland hematopoiesis" EXACT []
is_a: GO:0035166 ! post-embryonic hemopoiesis
relationship: part_of GO:0002164 ! larval development
relationship: part_of GO:0048542 ! lymph gland development

[Term]
id: GO:0035168
name: larval lymph gland hemocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
synonym: "larval lymph gland arthropod blood cell differentiation" EXACT []
is_a: GO:0042386 ! hemocyte differentiation
relationship: part_of GO:0035167 ! larval lymph gland hemopoiesis

[Term]
id: GO:0035169
name: lymph gland plasmatocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791]
synonym: "lymph gland plasmatocyte cell differentiation" EXACT []
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation
is_a: GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0035170
name: lymph gland crystal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation
is_a: GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0035171
name: lamellocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
synonym: "lamellocyte cell differentiation" EXACT []
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation

[Term]
id: GO:0035172
name: hemocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
synonym: "arthropod blood cell proliferation" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0035173
name: histone kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone." [GOC:bf]
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0035174
name: obsolete histone serine kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a phosphate group to a serine residue of a histone." [GOC:bf]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "histone-serine kinase activity" EXACT []
is_obsolete: true
consider: GO:0140995
consider: GO:0140996
consider: GO:0140997
consider: GO:0140998

[Term]
id: GO:0035175
name: histone H3S10 kinase activity
namespace: molecular_function
alt_id: GO:0044021
def: "Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3." [GOC:bf, PMID:15041176]
synonym: "histone kinase activity (H3-S10 specific)" EXACT []
synonym: "histone serine kinase activity (H3-S10 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0035176
name: social behavior
namespace: biological_process
def: "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior.
synonym: "cooperative behavior" RELATED []
synonym: "social behaviour" EXACT []
xref: Wikipedia:Social_behavior
is_a: GO:0007610 ! behavior
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms

[Term]
id: GO:0035177
name: larval foraging behavior
namespace: biological_process
def: "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927]
synonym: "larval foraging behaviour" EXACT []
is_a: GO:0030537 ! larval behavior
is_a: GO:0060756 ! foraging behavior

[Term]
id: GO:0035178
name: turning behavior
namespace: biological_process
def: "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source." [PMID:10880478]
synonym: "turning behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior

[Term]
id: GO:0035179
name: obsolete larval turning behavior
namespace: biological_process
def: "OBSOLETE. Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source." [PMID:10880478]
comment: The reason for obsoletion is that this term represent an assay and not a GO process.
synonym: "larval turning behaviour" EXACT []
is_obsolete: true
replaced_by: GO:0008345

[Term]
id: GO:0035180
name: larval wandering behavior
namespace: biological_process
def: "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960]
synonym: "larval wandering behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior

[Term]
id: GO:0035181
name: larval burrowing behavior
namespace: biological_process
def: "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation." [PMID:12848927, PMID:12848939]
synonym: "larval burrowing behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior

[Term]
id: GO:0035182
name: female germline ring canal outer rim
namespace: cellular_component
def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006]
comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'.
synonym: "germline ring canal outer rim" BROAD []
synonym: "nurse cell ring canal outer rim" NARROW []
synonym: "ovarian ring canal outer rim" NARROW []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0035324 ! female germline ring canal

[Term]
id: GO:0035183
name: female germline ring canal inner rim
namespace: cellular_component
def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858]
comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'.
synonym: "germline ring canal inner rim" BROAD []
synonym: "nurse cell ring canal inner rim" NARROW []
synonym: "ovarian ring canal inner rim" NARROW []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0035324 ! female germline ring canal

[Term]
id: GO:0035184
name: obsolete histone threonine kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a phosphate group to a threonine residue of a histone." [GOC:bf]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "histone-threonine kinase activity" EXACT []
is_obsolete: true
consider: GO:0140995
consider: GO:0140996
consider: GO:0140997
consider: GO:0140998

[Term]
id: GO:0035185
name: preblastoderm mitotic cell cycle
namespace: biological_process
def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis
is_a: GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0035186
name: syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis
is_a: GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0035187
name: hatching behavior
namespace: biological_process
def: "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051]
synonym: "hatching behaviour" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0035188 ! hatching

[Term]
id: GO:0035188
name: hatching
namespace: biological_process
def: "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001]
is_a: GO:0071684 ! organism emergence from protective structure
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0035189
name: Rb-E2F complex
namespace: cellular_component
def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073]
synonym: "retinoblastoma-E2F complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0035190
name: syncytial nuclear migration
namespace: biological_process
def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839]
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0035191
name: nuclear axial expansion
namespace: biological_process
def: "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839]
synonym: "nuclear distribution along anterior-posterior axis" EXACT []
synonym: "nucleus distribution along anterior-posterior axis" EXACT []
is_a: GO:0035190 ! syncytial nuclear migration

[Term]
id: GO:0035192
name: nuclear cortical migration
namespace: biological_process
def: "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo." [PMID:8314839]
is_a: GO:0035190 ! syncytial nuclear migration

[Term]
id: GO:0035193
name: larval central nervous system remodeling
namespace: biological_process
def: "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692]
synonym: "central nervous system metamorphosis" EXACT []
synonym: "CNS metamorphosis" EXACT []
synonym: "larval central nervous system remodelling" EXACT []
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0002165 ! instar larval or pupal development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0035194
name: regulatory ncRNA-mediated post-transcriptional gene silencing
namespace: biological_process
alt_id: GO:0016246
def: "A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation." [GOC:ems, PMID:11201747, PMID:11713190, PMID:15020054, PMID:15066275, PMID:18771919, PMID:32885814, PMID:33184244]
synonym: "cosuppression" RELATED []
synonym: "ncRNA-mediated post-transcriptional gene silencing" EXACT []
synonym: "post-transcriptional gene silencing by RNA" RELATED []
synonym: "posttranscriptional gene silencing by RNA" EXACT []
synonym: "PTGS" BROAD []
synonym: "quelling" RELATED []
synonym: "RNA interference" BROAD []
synonym: "RNA-dependent post-transcriptional gene silencing" EXACT []
synonym: "RNA-mediated post-transcriptional gene silencing" EXACT []
synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
synonym: "RNAi" BROAD []
xref: Wikipedia:RNA_interference
is_a: GO:0016441 ! post-transcriptional gene silencing
is_a: GO:0031047 ! regulatory ncRNA-mediated gene silencing

[Term]
id: GO:0035195
name: miRNA-mediated post-transcriptional gene silencing
namespace: biological_process
def: "A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants." [GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604]
synonym: "gene silencing by microRNA" EXACT [GOC:pr]
synonym: "gene silencing by miRNA" EXACT [GOC:dph, GOC:tb]
synonym: "microRNA-mediated gene silencing" EXACT []
synonym: "miRNA-mediated gene silencing" BROAD []
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0035196
name: miRNA processing
namespace: biological_process
alt_id: GO:0030918
def: "A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604]
synonym: "gene silencing by miRNA, production of miRNAs" EXACT [GOC:mah]
synonym: "microRNA biogenesis" EXACT [GOC:tb]
synonym: "microRNA biosynthesis" BROAD []
synonym: "microRNA biosynthetic process" BROAD []
synonym: "microRNA metabolic process" BROAD []
synonym: "microRNA metabolism" BROAD []
synonym: "microRNA processing" EXACT []
synonym: "microRNA-mediated gene silencing, production of microRNAs" EXACT []
synonym: "miRNA biogenesis" RELATED []
synonym: "miRNA biosynthetic process" BROAD []
synonym: "miRNA maturation" EXACT []
synonym: "miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:dph, GOC:tb]
synonym: "production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:pr]
synonym: "production of miRNAs involved in gene silencing by miRNA" EXACT []
is_a: GO:0070918 ! regulatory ncRNA processing

[Term]
id: GO:0035197
name: siRNA binding
namespace: molecular_function
def: "Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283]
synonym: "small interfering RNA binding" EXACT []
is_a: GO:0061980 ! regulatory RNA binding

[Term]
id: GO:0035198
name: miRNA binding
namespace: molecular_function
def: "Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]
synonym: "microRNA binding" EXACT []
is_a: GO:0061980 ! regulatory RNA binding

[Term]
id: GO:0035199
name: salt aversion
namespace: biological_process
def: "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
synonym: "behavioral response to salt" BROAD []
is_a: GO:0007631 ! feeding behavior
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0035200
name: leg disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc." [GOC:bf]
is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc
is_a: GO:0035223 ! leg disc pattern formation

[Term]
id: GO:0035201
name: leg disc anterior/posterior lineage restriction
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf]
is_a: GO:0048099 ! anterior/posterior lineage restriction, imaginal disc
relationship: part_of GO:0035200 ! leg disc anterior/posterior pattern formation

[Term]
id: GO:0035202
name: tracheal pit formation in open tracheal system
namespace: biological_process
def: "Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584]
synonym: "tracheal placode invagination" RELATED []
synonym: "tracheal sac formation" BROAD []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035203
name: regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
is_a: GO:0045610 ! regulation of hemocyte differentiation
is_a: GO:1903706 ! regulation of hemopoiesis
relationship: regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035204
name: negative regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
synonym: "down regulation of lamellocyte differentiation" EXACT []
synonym: "down-regulation of lamellocyte differentiation" EXACT []
synonym: "downregulation of lamellocyte differentiation" EXACT []
synonym: "inhibition of lamellocyte differentiation" NARROW []
is_a: GO:0035203 ! regulation of lamellocyte differentiation
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
relationship: negatively_regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035205
name: positive regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
synonym: "activation of lamellocyte differentiation" NARROW []
synonym: "stimulation of lamellocyte differentiation" NARROW []
synonym: "up regulation of lamellocyte differentiation" EXACT []
synonym: "up-regulation of lamellocyte differentiation" EXACT []
synonym: "upregulation of lamellocyte differentiation" EXACT []
is_a: GO:0035203 ! regulation of lamellocyte differentiation
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
relationship: positively_regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035206
name: regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "regulation of arthropod blood cell proliferation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035207
name: negative regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "down regulation of hemocyte proliferation" EXACT []
synonym: "down-regulation of hemocyte proliferation" EXACT []
synonym: "downregulation of hemocyte proliferation" EXACT []
synonym: "inhibition of hemocyte proliferation" NARROW []
synonym: "negative regulation of arthropod blood cell proliferation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0035206 ! regulation of hemocyte proliferation
relationship: negatively_regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035208
name: positive regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "activation of hemocyte proliferation" NARROW []
synonym: "positive regulation of arthropod blood cell proliferation" EXACT []
synonym: "stimulation of hemocyte proliferation" NARROW []
synonym: "up regulation of hemocyte proliferation" EXACT []
synonym: "up-regulation of hemocyte proliferation" EXACT []
synonym: "upregulation of hemocyte proliferation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0035206 ! regulation of hemocyte proliferation
relationship: positively_regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035209
name: pupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0035210
name: prepupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm]
comment: See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'.
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0035211
name: spermathecum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
comment: See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'.
is_a: GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0035212
name: cell competition in a multicellular organism
namespace: biological_process
def: "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
is_a: GO:0009987 ! cellular process
is_a: GO:0040008 ! regulation of growth
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0035213
name: clypeo-labral disc development
namespace: biological_process
def: "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite." [GOC:bf, ISBN:0879694238]
synonym: "development of structures derived from the clypeo-labral disc" EXACT []
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035214
name: eye-antennal disc development
namespace: biological_process
def: "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035215
name: genital disc development
namespace: biological_process
def: "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035216
name: haltere disc development
namespace: biological_process
def: "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035217
name: labial disc development
namespace: biological_process
def: "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035218
name: leg disc development
namespace: biological_process
def: "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035219
name: prothoracic disc development
namespace: biological_process
def: "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035220
name: wing disc development
namespace: biological_process
def: "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035221
name: genital disc pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035222
name: wing disc pattern formation
namespace: biological_process
def: "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0035223
name: leg disc pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035218 ! leg disc development

[Term]
id: GO:0035224
name: genital disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc
is_a: GO:0035221 ! genital disc pattern formation

[Term]
id: GO:0035225
name: determination of genital disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
is_a: GO:0007445 ! determination of imaginal disc primordium
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035226
name: glutamate-cysteine ligase catalytic subunit binding
namespace: molecular_function
def: "Binding to the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035227
name: regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that modulates the activity of glutamate-cysteine ligase." [GOC:bf]
subset: gocheck_obsoletion_candidate
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:0035228
name: obsolete negative regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "down-regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "downregulation of glutamate-cysteine ligase activity" EXACT []
synonym: "inhibition of glutamate-cysteine ligase activity" NARROW []
is_obsolete: true

[Term]
id: GO:0035229
name: positive regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617]
subset: gocheck_obsoletion_candidate
synonym: "activation of glutamate-cysteine ligase activity" NARROW []
synonym: "stimulation of glutamate-cysteine ligase activity" NARROW []
synonym: "up regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "up-regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "upregulation of glutamate-cysteine ligase activity" EXACT []
is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity
is_a: GO:0051351 ! positive regulation of ligase activity

[Term]
id: GO:0035230
name: cytoneme
namespace: cellular_component
def: "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901]
subset: goslim_pir
synonym: "membrane nanotube" EXACT [Wikipedia:Membrane_nanotube]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0035231
name: cytoneme assembly
namespace: biological_process
def: "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901]
synonym: "cytoneme biogenesis" RELATED [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
relationship: part_of GO:0003399 ! cytoneme morphogenesis

[Term]
id: GO:0035232
name: germ cell attraction
namespace: biological_process
def: "The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551]
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0008354 ! germ cell migration

[Term]
id: GO:0035233
name: germ cell repulsion
namespace: biological_process
def: "The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551]
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0008354 ! germ cell migration

[Term]
id: GO:0035234
name: ectopic germ cell programmed cell death
namespace: biological_process
def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
synonym: "programmed cell death of ectopic germ cells" EXACT []
synonym: "programmed cell death, ectopic germ cells" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! programmed cell death involved in cell development

[Term]
id: GO:0035235
name: ionotropic glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
synonym: "ionotropic glutamate receptor signalling pathway" EXACT []
is_a: GO:0007215 ! glutamate receptor signaling pathway
is_a: GO:1990806 ! ligand-gated ion channel signaling pathway

[Term]
id: GO:0035236
name: proctolin receptor activity
namespace: molecular_function
def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0035237
name: corazonin receptor activity
namespace: molecular_function
def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0035238
name: vitamin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606]
synonym: "vitamin A anabolism" EXACT []
synonym: "vitamin A biosynthesis" EXACT []
synonym: "vitamin A formation" EXACT []
synonym: "vitamin A synthesis" EXACT []
is_a: GO:0006776 ! vitamin A metabolic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process

[Term]
id: GO:0035239
name: tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0035295 ! tube development

[Term]
id: GO:0035240
name: dopamine binding
namespace: molecular_function
def: "Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732]
is_a: GO:0043169 ! cation binding
is_a: GO:1901338 ! catecholamine binding

[Term]
id: GO:0035241
name: protein-arginine omega-N monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069]
comment: Type III protein arginine methyltransferases catalyze the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyze this reaction, type III enzymes do not methylate the substrate any further.
synonym: "protein arginine omega-N monomethylase activity" EXACT []
synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)" RELATED [EC:2.1.1.321]
synonym: "type III protein arginine methyltransferase activity" RELATED [EC:2.1.1.321]
xref: EC:2.1.1.321
xref: RHEA:48100
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0035242
name: protein-arginine omega-N asymmetric methyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965]
comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'.
synonym: "protein arginine omega-N asymmetric methylase activity" EXACT []
synonym: "protein arginine omega-N asymmetric methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.319]
synonym: "type I PRMT activity" RELATED []
synonym: "type I protein arginine methyltransferase activity" RELATED [EC:2.1.1.319]
xref: EC:2.1.1.319
xref: Reactome:R-HSA-9729283 "Nucleoprotein is methylated by PRMT1"
xref: RHEA:48096
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0035243
name: protein-arginine omega-N symmetric methyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069]
comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'.
synonym: "protein arginine omega-N symmetric methylase activity" EXACT []
synonym: "protein arginine omega-N symmetric methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.320]
synonym: "type II PRMT activity" RELATED []
synonym: "type II protein arginine methyltransferase activity" RELATED []
xref: EC:2.1.1.320
xref: Reactome:R-HSA-6804383 "PRMT5 methylates TP53"
xref: RESID:AA0067
xref: RESID:AA0069
xref: RHEA:48108
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0035244
name: protein-arginine C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. This modification has been detected in anaerobic bacteria." [GOC:bf, PMID:29743535, PMID:33162960, RHEA:66028]
synonym: "peptidyl arginine C-methyltransferase activity" EXACT []
synonym: "peptidyl-arginine C-methylase activity" EXACT []
synonym: "peptidyl-arginine C-methyltransferase activity" EXACT []
synonym: "protein-arginine C-methylase activity" EXACT []
xref: EC:2.1.1.379
xref: RHEA:66028
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0035245
name: obsolete peptidyl-arginine C-methylation
namespace: biological_process
def: "OBSOLETE. The addition of a methyl group onto a carbon atom of an arginine residue in a protein." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0035244

[Term]
id: GO:0035246
name: peptidyl-arginine N-methylation
namespace: biological_process
def: "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf]
subset: gocheck_obsoletion_candidate
is_a: GO:0018216 ! peptidyl-arginine methylation

[Term]
id: GO:0035247
name: peptidyl-arginine omega-N-methylation
namespace: biological_process
def: "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0067
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0035246 ! peptidyl-arginine N-methylation

[Term]
id: GO:0035248
name: alpha-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086]
synonym: "alpha-1,4-GalNAc transferase activity" EXACT []
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0035249
name: synaptic transmission, glutamatergic
namespace: biological_process
def: "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]
synonym: "glutamatergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0035250
name: UDP-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0035251
name: UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [PMID:19858195]
xref: Reactome:R-HSA-1912353 "Glucosylation of Pre-NOTCH by POGLUT1"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0035252
name: UDP-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [PMID:30127001]
xref: Reactome:R-HSA-5617138 "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA"
xref: Reactome:R-HSA-6785668 "Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA"
xref: Reactome:R-HSA-9638090 "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0035253
name: ciliary rootlet
namespace: cellular_component
def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]
synonym: "cilial rootlet" EXACT []
synonym: "cilium rootlet" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0035254
name: glutamate receptor binding
namespace: molecular_function
def: "Binding to a glutamate receptor." [GOC:bf]
subset: goslim_chembl
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0035255
name: ionotropic glutamate receptor binding
namespace: molecular_function
def: "Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732]
is_a: GO:0035254 ! glutamate receptor binding

[Term]
id: GO:0035256
name: G protein-coupled glutamate receptor binding
namespace: molecular_function
def: "Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)." [GOC:bf, ISBN:0198506732, PMID:9069287]
synonym: "G-protein coupled glutamate receptor binding" EXACT []
synonym: "metabotropic glutamate receptor binding" EXACT [GOC:bf]
is_a: GO:0001664 ! G protein-coupled receptor binding
is_a: GO:0035254 ! glutamate receptor binding

[Term]
id: GO:0035259
name: nuclear glucocorticoid receptor binding
namespace: molecular_function
def: "Binding to a nuclear glucocorticoid receptor." [GOC:bf]
synonym: "glucocorticoid receptor binding" BROAD []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0035260
name: internal genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [PMID:24793987, PMID:25247640]
is_a: GO:0035112 ! genitalia morphogenesis

[Term]
id: GO:0035261
name: external genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [PMID:24793987, PMID:25247640]
is_a: GO:0035112 ! genitalia morphogenesis

[Term]
id: GO:0035262
name: gonad morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0008406 ! gonad development

[Term]
id: GO:0035263
name: genital disc sexually dimorphic development
namespace: biological_process
def: "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007548 ! sex differentiation
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035264
name: multicellular organism growth
namespace: biological_process
def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
synonym: "body growth" RELATED []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0035265
name: organ growth
namespace: biological_process
def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0035266
name: meristem growth
namespace: biological_process
def: "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:bf, ISBN:0198547684]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0035267
name: NuA4 histone acetyltransferase complex
namespace: cellular_component
def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
synonym: "TIP60 histone acetylase complex" EXACT []
synonym: "TIP60 histone acetyltransferase complex" EXACT []
is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex

[Term]
id: GO:0035268
name: protein mannosylation
namespace: biological_process
def: "The addition of a mannose residue to a protein acceptor molecule." [GOC:bf, GOC:pr]
synonym: "protein amino acid mannosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation
is_a: GO:0097502 ! mannosylation

[Term]
id: GO:0035269
name: protein O-linked mannosylation
namespace: biological_process
def: "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]
synonym: "protein amino acid O-linked mannosylation" EXACT [GOC:bf]
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0035268 ! protein mannosylation

[Term]
id: GO:0035270
name: endocrine system development
namespace: biological_process
def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system]
is_a: GO:0048731 ! system development

[Term]
id: GO:0035271
name: ring gland development
namespace: biological_process
def: "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098]
comment: See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799.
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0035272
name: exocrine system development
namespace: biological_process
def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland]
is_a: GO:0048731 ! system development

[Term]
id: GO:0035273
name: phthalate binding
namespace: molecular_function
def: "Binding to a phthalate, any ester or salt of phthalic acid." [PMID:31116073]
subset: goslim_pir
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0035274
name: diphenyl phthalate binding
namespace: molecular_function
def: "Binding to diphenyl phthalate, C(20)H(14)O(4)." [PMID:34697989]
synonym: "DPP binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0035275
name: dibutyl phthalate binding
namespace: molecular_function
def: "Binding to dibutyl phthalate, C(16)H(22)O(4)." [PMID:31954361, PMID:35408690]
synonym: "DBP binding" EXACT []
synonym: "phthalic acid dibutyl ester binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0035276
name: ethanol binding
namespace: molecular_function
def: "Binding to ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732]
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0035277
name: spiracle morphogenesis, open tracheal system
namespace: biological_process
def: "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
synonym: "spiracle morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035278
name: miRNA-mediated gene silencing by inhibition of translation
namespace: biological_process
def: "An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554]
synonym: "down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "gene silencing by miRNA, negative regulation of translation" EXACT [GOC:mah]
synonym: "inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:mah]
synonym: "miRNA mediated inhibition of translation" EXACT []
synonym: "miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:pr]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0035195 ! miRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0035279
name: miRNA-mediated gene silencing by mRNA destabilization
namespace: biological_process
def: "An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554, PMID:21118121, PMID:23209154]
synonym: "deadenylation involved in gene silencing by miRNA" RELATED []
synonym: "gene silencing by miRNA, mRNA cleavage" EXACT [GOC:mah]
synonym: "gene silencing by mRNA cleavage" BROAD []
synonym: "miRNA-mediated gene silencing by mRNA deadenylation" RELATED []
synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb]
synonym: "mRNA cleavage involved in gene silencing by microRNA" EXACT [GOC:pr]
synonym: "mRNA cleavage involved in gene silencing by miRNA" EXACT []
synonym: "mRNA deadenylation-mediated gene silencing by miRNA" RELATED []
synonym: "mRNA destabilization-mediated gene silencing by miRNA" EXACT []
is_a: GO:0035195 ! miRNA-mediated post-transcriptional gene silencing
is_a: GO:0061157 ! mRNA destabilization

[Term]
id: GO:0035281
name: pre-miRNA export from nucleus
namespace: biological_process
def: "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product." [GOC:sl, PMID:14744438]
synonym: "pre-microRNA export from cell nucleus" EXACT []
synonym: "pre-microRNA export from nucleus" RELATED []
synonym: "pre-microRNA export out of nucleus" EXACT []
synonym: "pre-microRNA transport from nucleus to cytoplasm" EXACT []
synonym: "pre-microRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
relationship: part_of GO:0035195 ! miRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0035282
name: segmentation
namespace: biological_process
def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
xref: Wikipedia:Segmentation_(biology)
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0035283
name: central nervous system segmentation
namespace: biological_process
def: "Division of the central nervous system into a series of semi-repetitive parts or segments." [GOC:bf]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0035284
name: brain segmentation
namespace: biological_process
def: "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007420 ! brain development
relationship: part_of GO:0035283 ! central nervous system segmentation

[Term]
id: GO:0035285
name: appendage segmentation
namespace: biological_process
def: "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented." [PMID:10357895]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0035107 ! appendage morphogenesis

[Term]
id: GO:0035286
name: obsolete leg segmentation
namespace: biological_process
def: "OBSOLETE. Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint." [PMID:10357895]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "leg segmentation" EXACT []
is_obsolete: true
consider: GO:0035285
consider: GO:0036011

[Term]
id: GO:0035287
name: head segmentation
namespace: biological_process
def: "Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837]
comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children.
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0007350 ! blastoderm segmentation
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0035288
name: anterior head segmentation
namespace: biological_process
def: "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136]
comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children.
synonym: "procephalic segmentation" RELATED []
is_a: GO:0035287 ! head segmentation
relationship: part_of GO:0097065 ! anterior head development

[Term]
id: GO:0035289
name: posterior head segmentation
namespace: biological_process
def: "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children.
synonym: "gnathal segmentation" RELATED []
is_a: GO:0035287 ! head segmentation

[Term]
id: GO:0035290
name: trunk segmentation
namespace: biological_process
def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0035291
name: specification of segmental identity, intercalary segment
namespace: biological_process
def: "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305]
comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035288 ! anterior head segmentation

[Term]
id: GO:0035292
name: specification of segmental identity, trunk
namespace: biological_process
def: "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [PMID:1360402]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0035290 ! trunk segmentation

[Term]
id: GO:0035293
name: chitin-based larval cuticle pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0035017 ! cuticle pattern formation
relationship: part_of GO:0008363 ! larval chitin-based cuticle development

[Term]
id: GO:0035294
name: determination of wing disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238]
is_a: GO:0007445 ! determination of imaginal disc primordium
is_a: GO:0035220 ! wing disc development

[Term]
id: GO:0035295
name: tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0035296
name: regulation of tube diameter
namespace: biological_process
def: "Any process that modulates the diameter of a tube." [GOC:bf]
is_a: GO:0035150 ! regulation of tube size

[Term]
id: GO:0035297
name: regulation of Malpighian tubule diameter
namespace: biological_process
def: "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producing tubes with a cirumference of two cells." [PMID:9286684]
is_a: GO:0035296 ! regulation of tube diameter
is_a: GO:0035298 ! regulation of Malpighian tubule size

[Term]
id: GO:0035298
name: regulation of Malpighian tubule size
namespace: biological_process
def: "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf]
is_a: GO:0035150 ! regulation of tube size
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0035299
name: inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H+." [RHEA:20313]
synonym: "inositol hexakisphosphate synthase" RELATED []
synonym: "inositol pentakisphosphate 2-kinase activity" EXACT []
synonym: "inositol polyphosphate kinase activity" RELATED [EC:2.7.1.158]
synonym: "inositol-pentakisphosphate 2-kinase activity" RELATED [EC:2.7.1.158]
synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" RELATED [EC:2.7.1.158]
synonym: "IP5 2-kinase activity" RELATED [EC:2.7.1.158]
xref: EC:2.7.1.158
xref: KEGG_REACTION:R05202
xref: MetaCyc:RXN-7163
xref: Reactome:R-HSA-1855176 "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus"
xref: Reactome:R-HSA-1855179 "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol"
xref: RHEA:20313
is_a: GO:0120517 ! inositol pentakisphosphate kinase activity

[Term]
id: GO:0035300
name: obsolete inositol-1,3,4-trisphosphate 5/6-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [PMID:9126335]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW []
synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW []
synonym: "inositol-1,3,4-trisphosphate 5/6-kinase activity" EXACT []
is_obsolete: true
consider: GO:0052725
consider: GO:0052726

[Term]
id: GO:0035301
name: Hedgehog signaling complex
namespace: cellular_component
def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936]
synonym: "Hedgehog signalling complex" EXACT []
synonym: "HSC" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0035302
name: ecdysteroid 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732, PMID:15350618]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol).
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0035303
name: regulation of dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035304
name: obsolete regulation of protein dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "regulation of protein amino acid dephosphorylation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035305
name: negative regulation of dephosphorylation
namespace: biological_process
def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
synonym: "down regulation of dephosphorylation" EXACT []
synonym: "down-regulation of dephosphorylation" EXACT []
synonym: "downregulation of dephosphorylation" EXACT []
synonym: "inhibition of dephosphorylation" NARROW []
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
relationship: negatively_regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035306
name: positive regulation of dephosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
synonym: "activation of dephosphorylation" NARROW []
synonym: "stimulation of dephosphorylation" NARROW []
synonym: "up regulation of dephosphorylation" EXACT []
synonym: "up-regulation of dephosphorylation" EXACT []
synonym: "upregulation of dephosphorylation" EXACT []
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
relationship: positively_regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035307
name: obsolete positive regulation of protein dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "activation of protein amino acid dephosphorylation" NARROW []
synonym: "positive regulation of protein amino acid dephosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid dephosphorylation" NARROW []
synonym: "up regulation of protein amino acid dephosphorylation" EXACT []
synonym: "up-regulation of protein amino acid dephosphorylation" EXACT []
synonym: "upregulation of protein amino acid dephosphorylation" EXACT []
is_obsolete: true

[Term]
id: GO:0035308
name: obsolete negative regulation of protein dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "down regulation of protein amino acid dephosphorylation" EXACT []
synonym: "down-regulation of protein amino acid dephosphorylation" EXACT []
synonym: "downregulation of protein amino acid dephosphorylation" EXACT []
synonym: "inhibition of protein amino acid dephosphorylation" NARROW []
synonym: "negative regulation of protein amino acid dephosphorylation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035309
name: wing and notum subfield formation
namespace: biological_process
def: "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0035310
name: notum cell fate specification
namespace: biological_process
def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999]
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0035309 ! wing and notum subfield formation

[Term]
id: GO:0035311
name: wing cell fate specification
namespace: biological_process
def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999]
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0035309 ! wing and notum subfield formation

[Term]
id: GO:0035312
name: 5'-3' DNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]
synonym: "5'-3' exodeoxyribonuclease activity" EXACT []
is_a: GO:0008409 ! 5'-3' exonuclease activity
is_a: GO:0016895 ! DNA exonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0035313
name: wound healing, spreading of epidermal cells
namespace: biological_process
def: "The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis." [GOC:bf, PMID:15269788]
is_a: GO:0044319 ! wound healing, spreading of cells

[Term]
id: GO:0035314
name: scab formation
namespace: biological_process
def: "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0035315
name: hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf]
is_a: GO:0009913 ! epidermal cell differentiation
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0035316
name: non-sensory hair organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425]
comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'.
synonym: "non-sensory hair organization and biogenesis" RELATED [GOC:mah]
synonym: "trichome organisation" BROAD []
synonym: "trichome organization and biogenesis" BROAD []
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
relationship: part_of GO:0035315 ! hair cell differentiation

[Term]
id: GO:0035317
name: imaginal disc-derived wing hair organization
namespace: biological_process
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'.
synonym: "imaginal disc-derived wing hair organization and biogenesis" RELATED [GOC:mah]
synonym: "wing hair organisation" EXACT []
synonym: "wing hair organization and biogenesis" RELATED [GOC:mah]
synonym: "wing trichome organization and biogenesis" EXACT []
is_a: GO:0035316 ! non-sensory hair organization
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0035318
name: imaginal disc-derived wing hair outgrowth
namespace: biological_process
def: "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551]
synonym: "wing hair outgrowth" EXACT []
synonym: "wing prehair outgrowth" RELATED []
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035319
name: imaginal disc-derived wing hair elongation
namespace: biological_process
def: "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles." [GOC:mtg_sensu, PMID:11832234]
synonym: "wing hair elongation" EXACT []
synonym: "wing prehair extension" RELATED []
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035320
name: imaginal disc-derived wing hair site selection
namespace: biological_process
def: "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551]
synonym: "prehair localization" RELATED []
synonym: "wing hair site selection" EXACT []
is_a: GO:0022606 ! establishment of proximal/distal cell polarity
relationship: part_of GO:0001737 ! establishment of imaginal disc-derived wing hair orientation

[Term]
id: GO:0035321
name: maintenance of imaginal disc-derived wing hair orientation
namespace: biological_process
def: "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220]
synonym: "maintenance of wing hair orientation" EXACT []
is_a: GO:0009954 ! proximal/distal pattern formation
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035322
name: mesenchymal cell migration involved in limb bud formation
namespace: biological_process
def: "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud." [GOC:dgh]
is_a: GO:0090497 ! mesenchymal cell migration
relationship: part_of GO:0090496 ! mesenchyme migration involved in limb bud formation

[Term]
id: GO:0035323
name: male germline ring canal
namespace: cellular_component
def: "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420]
synonym: "spermatocyte ring canal" NARROW []
synonym: "testicular ring canal" NARROW []
is_a: GO:0045172 ! germline ring canal

[Term]
id: GO:0035324
name: female germline ring canal
namespace: cellular_component
def: "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
synonym: "nurse cell ring canal" NARROW []
synonym: "ovarian ring canal" NARROW []
is_a: GO:0045172 ! germline ring canal

[Term]
id: GO:0035325
name: Toll-like receptor binding
namespace: molecular_function
def: "Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response." [PMID:19076341]
synonym: "TLR binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0035329
name: hippo signaling
namespace: biological_process
def: "An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846]
synonym: "hippo signal transduction" EXACT [GOC:signaling]
synonym: "hippo signaling cascade" RELATED [GOC:signaling]
synonym: "hippo signaling pathway" EXACT []
synonym: "hippo signalling cascade" RELATED [GOC:mah]
synonym: "Salvador-Warts-Hippo signaling pathway" NARROW []
synonym: "SWH pathway" NARROW []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0035330
name: regulation of hippo signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf]
synonym: "regulation of hippo signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of hippo signaling pathway" EXACT []
synonym: "regulation of hippo signalling cascade" RELATED [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0035329 ! hippo signaling

[Term]
id: GO:0035331
name: negative regulation of hippo signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]
synonym: "negative regulation of hippo signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of hippo signaling pathway" EXACT []
synonym: "negative regulation of hippo signalling cascade" RELATED [GOC:mah]
is_a: GO:0035330 ! regulation of hippo signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0035329 ! hippo signaling

[Term]
id: GO:0035332
name: positive regulation of hippo signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]
synonym: "positive regulation of hippo signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of hippo signaling pathway" EXACT []
synonym: "positive regulation of hippo signalling cascade" RELATED [GOC:mah]
is_a: GO:0035330 ! regulation of hippo signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0035329 ! hippo signaling

[Term]
id: GO:0035333
name: Notch receptor processing, ligand-dependent
namespace: biological_process
def: "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD)." [GOC:bf, PMID:12651094]
synonym: "Notch S2 cleavage" NARROW [PMID:12651094]
synonym: "Notch S3 cleavage" NARROW [PMID:12651094]
is_a: GO:0031293 ! membrane protein intracellular domain proteolysis
relationship: part_of GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0007220 ! Notch receptor processing

[Term]
id: GO:0035334
name: Notch receptor processing, ligand-independent
namespace: biological_process
def: "The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface." [GOC:bf, PMID:12651094]
synonym: "Notch S1 cleavage" NARROW [PMID:12651094]
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0007220 ! Notch receptor processing

[Term]
id: GO:0035335
name: peptidyl-tyrosine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
subset: gocheck_obsoletion_candidate
is_a: GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0035336
name: long-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acyl CoA metabolic process" EXACT []
synonym: "long-chain fatty acyl-CoA metabolism" EXACT []
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:0035337
name: fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]
synonym: "fatty acyl CoA metabolic process" EXACT []
synonym: "fatty-acyl-CoA metabolism" EXACT []
is_a: GO:0006637 ! acyl-CoA metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:0035338
name: long-chain fatty-acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acyl CoA biosynthetic process" EXACT []
synonym: "long-chain fatty-acyl-CoA anabolism" EXACT []
synonym: "long-chain fatty-acyl-CoA biosynthesis" EXACT []
synonym: "long-chain fatty-acyl-CoA formation" EXACT []
synonym: "long-chain fatty-acyl-CoA synthesis" EXACT []
is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process

[Term]
id: GO:0035339
name: obsolete SPOTS complex
namespace: cellular_component
def: "OBSOLETE. A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis." [PMID:20182505]
comment: The reason for obsoletion is that this term is equivalent to serine C-palmitoyltransferase complex.
synonym: "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex" NARROW []
is_obsolete: true
replaced_by: GO:0017059

[Term]
id: GO:0035340
name: inosine transport
namespace: biological_process
def: "The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:19135251]
synonym: "hypoxanthine riboside transport" EXACT []
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0035341
name: regulation of inosine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "regulation of hypoxanthine riboside transport" EXACT []
is_a: GO:0032245 ! regulation of purine nucleoside transport
relationship: regulates GO:0035340 ! inosine transport

[Term]
id: GO:0035342
name: positive regulation of inosine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "positive regulation of hypoxanthine riboside transport" EXACT []
is_a: GO:0032248 ! positive regulation of purine nucleoside transport
is_a: GO:0035341 ! regulation of inosine transport
relationship: positively_regulates GO:0035340 ! inosine transport

[Term]
id: GO:0035343
name: negative regulation of inosine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "negative regulation of hypoxanthine riboside transport" EXACT []
is_a: GO:0032247 ! negative regulation of purine nucleoside transport
is_a: GO:0035341 ! regulation of inosine transport
relationship: negatively_regulates GO:0035340 ! inosine transport

[Term]
id: GO:0035344
name: hypoxanthine transport
namespace: biological_process
def: "The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sl]
synonym: "6-hydroxypurine transport" EXACT []
synonym: "hypoxanthine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006863 ! purine nucleobase transport

[Term]
id: GO:0035345
name: regulation of hypoxanthine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "regulation of 6-hydroxypurine transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
relationship: regulates GO:0035344 ! hypoxanthine transport

[Term]
id: GO:0035346
name: positive regulation of hypoxanthine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "positive regulation of 6-hydroxypurine transport" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0035345 ! regulation of hypoxanthine transport
relationship: positively_regulates GO:0035344 ! hypoxanthine transport

[Term]
id: GO:0035347
name: negative regulation of hypoxanthine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "negative regulation of 6-hydroxypurine transport" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0035345 ! regulation of hypoxanthine transport
relationship: negatively_regulates GO:0035344 ! hypoxanthine transport

[Term]
id: GO:0035348
name: acetyl-CoA transmembrane transport
namespace: biological_process
def: "The process in which acetyl-CoA is transported across a membrane. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GO:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "acetyl-CoA membrane transport" EXACT []
is_a: GO:0015876 ! acetyl-CoA transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport

[Term]
id: GO:0035349
name: coenzyme A transmembrane transport
namespace: biological_process
def: "The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "coenzyme A membrane transport" EXACT []
is_a: GO:0015880 ! coenzyme A transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport

[Term]
id: GO:0035350
name: FAD transmembrane transport
namespace: biological_process
def: "The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [GOC:bf, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "FAD membrane transport" EXACT []
is_a: GO:0015883 ! FAD transport
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:0035351
name: heme transmembrane transport
namespace: biological_process
def: "The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "heme membrane transport" EXACT []
is_a: GO:0015886 ! heme transport
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0035352
name: NAD transmembrane transport
namespace: biological_process
def: "The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "NAD membrane transport" EXACT []
is_a: GO:0043132 ! NAD transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:0035353
name: nicotinamide mononucleotide transmembrane transport
namespace: biological_process
def: "The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [GOC:bf, ISBN:0721662544]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nicotinamide mononucleotide membrane transport" EXACT []
is_a: GO:0015890 ! nicotinamide mononucleotide transport
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:0035354
name: Toll-like receptor 1-Toll-like receptor 2 protein complex
namespace: cellular_component
alt_id: GO:0038125
def: "A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2)." [GOC:add, GOC:signaling, PMID:17889651, PMID:21481769]
synonym: "TLR1-TLR2 protein complex" EXACT []
synonym: "TLR1:TLR2 complex" EXACT []
synonym: "TLR2:TLR1 heterodimer" EXACT [GOC:bf]
synonym: "toll-like receptor TLR1:TLR2 heterodimeric complex" EXACT [GOC:bf]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0035355
name: Toll-like receptor 2-Toll-like receptor 6 protein complex
namespace: cellular_component
alt_id: GO:0038126
def: "A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6)." [GOC:add, GOC:signaling, PMID:19931471, PMID:21481769]
synonym: "TLR2-TLR6 protein complex" EXACT []
synonym: "TLR2:TLR6 heterodimer" EXACT [GOC:bf]
synonym: "TLR6:TLR2 complex" EXACT []
synonym: "toll-like receptor TLR6:TLR2 heterodimeric complex" EXACT [GOC:bf]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0035356
name: intracellular triglyceride homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell." [GOC:BHF]
synonym: "cellular triglyceride homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis
is_a: GO:0070328 ! triglyceride homeostasis

[Term]
id: GO:0035357
name: peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a ligand binding to an intracellular peroxisome proliferator activated receptor (alpha, beta or gamma) of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:18221086]
synonym: "peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "PPAR signaling pathway" EXACT []
is_a: GO:0141193 ! nuclear receptor-mediated signaling pathway

[Term]
id: GO:0035358
name: regulation of peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf]
synonym: "regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "regulation of PPAR signaling pathway" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway

[Term]
id: GO:0035359
name: negative regulation of peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf]
synonym: "negative regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "negative regulation of PPAR signaling pathway" EXACT []
is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway

[Term]
id: GO:0035360
name: positive regulation of peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf]
synonym: "positive regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "positive regulation of PPAR signaling pathway" EXACT []
is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway

[Term]
id: GO:0035361
name: Cul8-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins." [GOC:krc, PMID:20139071]
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0035362
name: protein-DNA ISRE complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, PMID:11747630]
synonym: "protein-DNA interferon-stimulated response element complex assembly" EXACT []
is_a: GO:0065004 ! protein-DNA complex assembly

[Term]
id: GO:0035363
name: histone locus body
namespace: cellular_component
def: "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235]
synonym: "HLB" EXACT [PMID:16533947, PMID:18927579, PMID:19620235]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0035364
name: thymine transport
namespace: biological_process
def: "The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO:sl]
synonym: "5-methyluracil transport" EXACT []
synonym: "thymine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0015855 ! pyrimidine nucleobase transport

[Term]
id: GO:0035365
name: regulation of thymine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl]
synonym: "regulation of 5-methyluracil transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
relationship: regulates GO:0035364 ! thymine transport

[Term]
id: GO:0035366
name: negative regulation of thymine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl]
synonym: "negative regulation of 5-methyluracil transport" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0035365 ! regulation of thymine transport
relationship: negatively_regulates GO:0035364 ! thymine transport

[Term]
id: GO:0035367
name: positive regulation of thymine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl]
synonym: "positive regulation of 5-methyluracil transport" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0035365 ! regulation of thymine transport
relationship: positively_regulates GO:0035364 ! thymine transport

[Term]
id: GO:0035368
name: selenocysteine insertion sequence binding
namespace: molecular_function
def: "Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation." [GOC:imk, PMID:10760958]
synonym: "SECIS binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0035369
name: pre-B cell receptor complex
namespace: cellular_component
def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522]
comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
synonym: "pre-BCR" EXACT []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0035370
name: obsolete UBC13-UEV1A complex
namespace: cellular_component
def: "OBSOLETE. A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A)." [GOC:amm, PMID:16129784]
comment: This term was obsoleted because it represents the same concept as UBC13-MMS2 complex ; GO:0031372.
is_obsolete: true
replaced_by: GO:0031372

[Term]
id: GO:0035371
name: microtubule plus-end
namespace: cellular_component
def: "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
synonym: "growing microtubule plus end" EXACT []
synonym: "microtubule plus end" EXACT []
is_a: GO:1990752 ! microtubule end

[Term]
id: GO:0035372
name: protein localization to microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb]
synonym: "protein localisation to microtubule" EXACT [GOC:mah]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton

[Term]
id: GO:0035373
name: chondroitin sulfate proteoglycan binding
namespace: molecular_function
def: "Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit." [GOC:kmv, ISBN:0198506732]
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:0043394 ! proteoglycan binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0035374
name: chondroitin sulfate binding
namespace: molecular_function
def: "Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)." [GOC:kmv, ISBN:0198506732]
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0035375
name: zymogen binding
namespace: molecular_function
def: "Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." [ISBN:0198506732]
synonym: "proenzyme binding" NARROW [ISBN:0198506732]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035376
name: sterol import
namespace: biological_process
def: "The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, PMID:19793923]
synonym: "sterol influx" EXACT [PMID:12077145]
synonym: "sterol uptake" EXACT [PMID:12077145]
is_a: GO:0015918 ! sterol transport

[Term]
id: GO:0035377
name: transepithelial water transport
namespace: biological_process
def: "The directed movement of water (H2O) from one side of an epithelium to the other." [GOC:yaf]
is_a: GO:0006833 ! water transport
is_a: GO:0042045 ! epithelial fluid transport

[Term]
id: GO:0035378
name: carbon dioxide transmembrane transport
namespace: biological_process
def: "The process in which carbon dioxide (CO2) is transported across a membrane." [GOC:yaf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "carbon dioxide membrane transport" EXACT []
is_a: GO:0015670 ! carbon dioxide transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0035379
name: carbon dioxide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other." [GOC:yaf]
xref: Reactome:R-HSA-1237042 "AQP1 tetramer transports CO2 from extracellular region to cytosol"
xref: Reactome:R-HSA-1237069 "RHAG transports CO2 from extracellular region to cytosol"
xref: Reactome:R-HSA-1247645 "RHAG transports CO2 from cytosol to extracellular region"
xref: Reactome:R-HSA-1247649 "AQP1 tetramer transports CO2 from cytosol to extracellular region"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0035380
name: very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:pde]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity" EXACT []
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0035381
name: ATP-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf]
is_a: GO:0022834 ! ligand-gated channel activity

[Term]
id: GO:0035382
name: sterol transmembrane transport
namespace: biological_process
def: "The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "sterol membrane transport" EXACT []
is_a: GO:0015918 ! sterol transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0035383
name: thioester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [GOC:bf, Wikipedia:Thioester]
synonym: "thioester metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0035384
name: thioester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester]
synonym: "thioester anabolism" EXACT []
synonym: "thioester biosynthesis" EXACT []
synonym: "thioester formation" EXACT []
synonym: "thioester synthesis" EXACT []
is_a: GO:0035383 ! thioester metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0035385
name: Roundabout signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a SLIT protein binding to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "ROBO signaling pathway" EXACT []
synonym: "ROBO/SLIT signaling pathway" EXACT []
synonym: "Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0035386
name: regulation of Roundabout signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF]
synonym: "regulation of Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0035385 ! Roundabout signaling pathway

[Term]
id: GO:0035387
name: negative regulation of Roundabout signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF]
synonym: "negative regulation of Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0035386 ! regulation of Roundabout signaling pathway
relationship: negatively_regulates GO:0035385 ! Roundabout signaling pathway

[Term]
id: GO:0035388
name: positive regulation of Roundabout signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF]
synonym: "positive regulation of Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0035386 ! regulation of Roundabout signaling pathway
relationship: positively_regulates GO:0035385 ! Roundabout signaling pathway

[Term]
id: GO:0035391
name: obsolete maintenance of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci." [GOC:vw]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0035392
name: obsolete maintenance of chromatin silencing at telomere
namespace: biological_process
def: "OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere." [GOC:vw]
comment: This term was obsoleted because it represented a phenotype.
is_obsolete: true

[Term]
id: GO:0035393
name: chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add]
subset: gocheck_do_not_annotate
synonym: "CXCL9 production" EXACT []
synonym: "MIG production" EXACT []
synonym: "Monokine induced by gamma interferon production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0035394
name: regulation of chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf]
synonym: "regulation of CXCL9 production" EXACT []
synonym: "regulation of MIG production" EXACT []
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production

[Term]
id: GO:0035395
name: negative regulation of chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf]
synonym: "negative regulation of CXCL9 production" EXACT []
synonym: "negative regulation of MIG production" EXACT []
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production
relationship: negatively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production

[Term]
id: GO:0035396
name: positive regulation of chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf]
synonym: "positive regulation of CXCL9 production" EXACT []
synonym: "positive regulation of MIG production" EXACT []
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production
relationship: positively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production

[Term]
id: GO:0035397
name: helper T cell enhancement of adaptive immune response
namespace: biological_process
def: "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell." [GOC:add]
synonym: "provision of T cell help" EXACT []
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0035398
name: helper T cell enhancement of T cell mediated immune response
namespace: biological_process
def: "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add]
synonym: "helper T cell enhancement of T cell mediated immunity" EXACT []
synonym: "provision of T cell help to T cell" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response

[Term]
id: GO:0035399
name: helper T cell enhancement of B cell mediated immune response
namespace: biological_process
def: "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add]
synonym: "helper T cell enhancement of B cell mediated immunity" EXACT []
synonym: "provision of T cell help to B cell" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response

[Term]
id: GO:0035400
name: obsolete histone tyrosine kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone." [GOC:bf]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "histone-tyrosine kinase activity" EXACT []
is_obsolete: true
consider: GO:0140995
consider: GO:0140996
consider: GO:0140997
consider: GO:0140998

[Term]
id: GO:0035401
name: histone H3Y41 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3." [GOC:bf]
synonym: "histone H3-Y41 kinase activity" EXACT []
synonym: "histone kinase activity (H3-Y41 specific)" EXACT []
synonym: "histone tyrosine kinase activity (H3-Y41 specific)" EXACT []
synonym: "histone-tyrosine kinase activity (H3-Y41 specific)" EXACT []
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0035402
name: histone H3T11 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3." [GOC:bf]
synonym: "histone H3-T11 kinase activity" EXACT []
synonym: "histone kinase activity (H3-T11 specific)" EXACT []
synonym: "histone threonine kinase activity (H3-T11 specific)" EXACT []
synonym: "histone-threonine kinase activity (H3-T11 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0035403
name: histone H3T6 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3." [GOC:bf]
synonym: "histone H3-T6 kinase activity" EXACT []
synonym: "histone kinase activity (H3-T6 specific)" EXACT []
synonym: "histone threonine kinase activity (H3-T6 specific)" EXACT []
synonym: "histone-threonine kinase activity (H3-T6 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0035404
name: obsolete histone-serine phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by addition of a phosphate group to a serine residue." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone serine phosphorylation" EXACT []
is_obsolete: true
consider: GO:0035173

[Term]
id: GO:0035405
name: obsolete histone-threonine phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by addition of a phosphate group to a threonine residue." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone threonine phosphorylation" EXACT []
is_obsolete: true

[Term]
id: GO:0035406
name: obsolete histone-tyrosine phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histones by addition of a phosphate group to a tyrosine residue." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone tyrosine phosphorylation" EXACT []
is_obsolete: true
consider: GO:0035173

[Term]
id: GO:0035407
name: obsolete histone H3-T11 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035402

[Term]
id: GO:0035408
name: obsolete histone H3-T6 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035403

[Term]
id: GO:0035409
name: obsolete histone H3-Y41 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035401

[Term]
id: GO:0035410
name: obsolete dihydrotestosterone 17-beta-dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH." [GOC:ecd, PMID:4152755]
comment: This term was obsoleted because it represents a specific substrate of testosterone dehydrogenase [NAD(P)+] activity ; GO:0030283.
is_obsolete: true
replaced_by: GO:0030283

[Term]
id: GO:0035415
name: obsolete regulation of mitotic prometaphase
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of mitotic prometaphase" EXACT []
is_obsolete: true

[Term]
id: GO:0035416
name: obsolete positive regulation of mitotic prometaphase
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "positive regulation of mitotic prometaphase" EXACT []
is_obsolete: true

[Term]
id: GO:0035417
name: obsolete negative regulation of mitotic prometaphase
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "negative regulation of mitotic prometaphase" EXACT []
is_obsolete: true

[Term]
id: GO:0035418
name: protein localization to synapse
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]
synonym: "protein localisation to synapse" EXACT [GOC:mah]
is_a: GO:1902414 ! protein localization to cell junction

[Term]
id: GO:0035419
name: obsolete activation of MAPK activity involved in innate immune response
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
comment: This term was obsoleted because it should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0035420
name: obsolete MAPK cascade involved in innate immune response
namespace: biological_process
def: "OBSOLETE. A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "MAPKKK cascade involved in innate immune response" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0035421
name: obsolete activation of MAPKK activity involved in innate immune response
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035422
name: obsolete activation of MAPKKK activity involved in innate immune response
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
comment: This term was obsoleted because it should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0035423
name: obsolete inactivation of MAPK activity involved in innate immune response
namespace: biological_process
def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0035424
name: obsolete MAPK import into nucleus involved in innate immune response
namespace: biological_process
def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "nuclear translocation of MAPK involved in innate immune response" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0035425
name: autocrine signaling
namespace: biological_process
def: "Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type." [GOC:bf, ISBN:3527303782]
synonym: "autocrine signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0035426
name: extracellular matrix-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information between the extracellular matrix and a cell." [GOC:bf]
synonym: "cell-extracellular matrix signalling" EXACT []
synonym: "extracellular matrix-cell signalling" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023052 ! signaling

[Term]
id: GO:0035429
name: gluconate transmembrane transport
namespace: biological_process
alt_id: GO:0015725
def: "The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose." [GOC:vw, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "gluconate membrane transport" EXACT []
synonym: "gluconate transport" RELATED []
is_a: GO:0042873 ! aldonate transmembrane transport

[Term]
id: GO:0035430
name: regulation of gluconate transmembrane transport
namespace: biological_process
alt_id: GO:0032893
def: "Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "regulation of gluconate membrane transport" EXACT []
synonym: "regulation of gluconate transport" RELATED []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:0035429 ! gluconate transmembrane transport

[Term]
id: GO:0035431
name: negative regulation of gluconate transmembrane transport
namespace: biological_process
alt_id: GO:0032894
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "down regulation of gluconate transport" EXACT []
synonym: "down-regulation of gluconate transport" EXACT []
synonym: "downregulation of gluconate transport" EXACT []
synonym: "inhibition of gluconate transport" NARROW []
synonym: "negative regulation of gluconate membrane transport" EXACT []
synonym: "negative regulation of gluconate transport" RELATED []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0035430 ! regulation of gluconate transmembrane transport
relationship: negatively_regulates GO:0035429 ! gluconate transmembrane transport

[Term]
id: GO:0035432
name: positive regulation of gluconate transmembrane transport
namespace: biological_process
alt_id: GO:0032895
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "activation of gluconate transport" NARROW []
synonym: "induction of gluconate transport" NARROW []
synonym: "positive regulation of gluconate membrane transport" EXACT []
synonym: "positive regulation of gluconate transport" RELATED []
synonym: "stimulation of gluconate transport" NARROW []
synonym: "up regulation of gluconate transport" EXACT []
synonym: "up-regulation of gluconate transport" EXACT []
synonym: "upregulation of gluconate transport" EXACT []
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0035430 ! regulation of gluconate transmembrane transport
relationship: positively_regulates GO:0035429 ! gluconate transmembrane transport

[Term]
id: GO:0035433
name: acetate transmembrane transport
namespace: biological_process
def: "The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "acetate membrane transport" EXACT []
is_a: GO:0006846 ! acetate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0035434
name: copper ion transmembrane transport
namespace: biological_process
alt_id: GO:1901473
def: "The directed movement of copper cation across a membrane." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "copper cation transmembrane transport" EXACT []
synonym: "copper ion membrane transport" EXACT []
is_a: GO:0006825 ! copper ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0035435
name: phosphate ion transmembrane transport
namespace: biological_process
def: "The process in which a phosphate is transported across a membrane." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "phosphate ion membrane transport" EXACT []
is_a: GO:0006817 ! phosphate ion transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:0035436
name: triose phosphate transmembrane transport
namespace: biological_process
def: "The process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester." [GOC:bf, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "triose phosphate membrane transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015717 ! triose phosphate transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0035437
name: maintenance of protein localization in endoplasmic reticulum
namespace: biological_process
def: "Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum." [GOC:bf, GOC:vw]
synonym: "maintenance of protein localisation in endoplasmic reticulum" EXACT [GOC:mah]
synonym: "maintenance of protein localization in ER" EXACT []
synonym: "maintenance of protein location in endoplasmic reticulum" EXACT []
synonym: "maintenance of protein location in ER" EXACT []
synonym: "protein-endoplasmic reticulum retention" EXACT []
synonym: "protein-ER retention" EXACT []
synonym: "retention of protein in endoplasmic reticulum" EXACT []
synonym: "retention of protein in ER" EXACT []
is_a: GO:0072595 ! maintenance of protein localization in organelle
relationship: part_of GO:0070972 ! protein localization to endoplasmic reticulum

[Term]
id: GO:0035438
name: cyclic-di-GMP binding
namespace: molecular_function
def: "Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate." [GOC:bf]
synonym: "3',5'-cyclic di-GMP binding" EXACT []
synonym: "c-di-GMP binding" EXACT []
synonym: "cyclic dinucleotide di-GMP binding" EXACT []
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0035439
name: halimadienyl-diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate." [EC:5.5.1.16]
synonym: "halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)" RELATED [EC:5.5.1.16]
synonym: "halimadienyl diphosphate synthase activity" RELATED [EC:5.5.1.16]
xref: EC:5.5.1.16
xref: RHEA:25621
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0035440
name: tuberculosinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria." [MetaCyc:PWY-5935]
synonym: "halima-5,6,dien-15-ol biosynthesis" EXACT []
synonym: "halima-5,6,dien-15-ol biosynthetic process" EXACT []
synonym: "tuberculosinol biosynthesis" EXACT []
xref: MetaCyc:PWY-5935
is_a: GO:0016102 ! diterpenoid biosynthetic process

[Term]
id: GO:0035441
name: cell migration involved in vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0001570 ! vasculogenesis

[Term]
id: GO:0035442
name: dipeptide transmembrane transport
namespace: biological_process
def: "The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "dipeptide membrane transport" EXACT []
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0042938 ! dipeptide transport

[Term]
id: GO:0035443
name: tripeptide transmembrane transport
namespace: biological_process
def: "The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "tripeptide membrane transport" EXACT []
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0042939 ! tripeptide transport

[Term]
id: GO:0035444
name: nickel cation transmembrane transport
namespace: biological_process
def: "The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nickel cation membrane transport" EXACT []
is_a: GO:0015675 ! nickel cation transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0035445
name: borate transmembrane transport
namespace: biological_process
def: "The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [GOC:curators]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "borate membrane transport" EXACT []
synonym: "boron transmembrane transport" RELATED []
is_a: GO:0046713 ! borate transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:0035446
name: cysteine-glucosaminylinositol ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins." [EC:6.3.1.13, PMID:12033919]
synonym: "desacetylmycothiol synthase" RELATED [PMID:12033919]
synonym: "L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase" RELATED [EC:6.3.1.13]
synonym: "MshC ligase" RELATED [EC:6.3.1.13]
xref: EC:6.3.1.13
xref: MetaCyc:RXN1G-121
xref: RHEA:26176
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0035447
name: mycothiol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol-2-(L-cysteinylamido)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coA + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol." [EC:2.3.1.189, PMID:12033919]
synonym: "acetyl-CoA:Cys-GlcN-Ins acetyltransferase" EXACT []
xref: EC:2.3.1.189
xref: MetaCyc:RXN1G-4
xref: RHEA:26172
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0035448
name: extrinsic component of thylakoid membrane
namespace: cellular_component
def: "The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to thylakoid membrane" NARROW []
synonym: "peripheral to thylakoid membrane" EXACT []
is_a: GO:0019898 ! extrinsic component of membrane
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0035449
name: extrinsic component of plastid thylakoid membrane
namespace: cellular_component
def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to plastid thylakoid membrane" NARROW []
synonym: "peripheral to plastid thylakoid membrane" EXACT []
is_a: GO:0035448 ! extrinsic component of thylakoid membrane
is_a: GO:0035452 ! extrinsic component of plastid membrane
relationship: part_of GO:0055035 ! plastid thylakoid membrane

[Term]
id: GO:0035450
name: extrinsic component of lumenal side of plastid thylakoid membrane
namespace: cellular_component
def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to lumenal leaflet of plastid thylakoid membrane" EXACT [GOC:ab]
synonym: "extrinsic to lumenal side of plastid thylakoid membrane" NARROW []
synonym: "peripheral to lumenal side of plastid thylakoid membrane" EXACT []
is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane
is_a: GO:0035453 ! extrinsic component of plastid inner membrane
relationship: part_of GO:0098570 ! stromal side of plastid inner membrane

[Term]
id: GO:0035451
name: extrinsic component of stromal side of plastid thylakoid membrane
namespace: cellular_component
def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to stromal leaflet of plastid thylakoid membrane" EXACT [GOC:ab]
synonym: "extrinsic to stromal side of plastid thylakoid membrane" NARROW []
synonym: "peripheral to stromal side of plastid thylakoid membrane" EXACT []
is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane
relationship: part_of GO:0098572 ! stromal side of plastid thylakoid membrane

[Term]
id: GO:0035452
name: extrinsic component of plastid membrane
namespace: cellular_component
def: "The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to plastid membrane" NARROW []
synonym: "peripheral to plastid membrane" EXACT []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0042170 ! plastid membrane

[Term]
id: GO:0035453
name: extrinsic component of plastid inner membrane
namespace: cellular_component
def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to plastid inner membrane" NARROW []
synonym: "peripheral to plastid inner membrane" EXACT []
is_a: GO:0035452 ! extrinsic component of plastid membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0035454
name: extrinsic component of stromal side of plastid inner membrane
namespace: cellular_component
def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to stromal leaflet of plastid inner membrane" EXACT [GOC:ab]
synonym: "extrinsic to stromal side of plastid inner membrane" NARROW []
synonym: "peripheral to stromal side of plastid inner membrane" EXACT []
is_a: GO:0035450 ! extrinsic component of lumenal side of plastid thylakoid membrane

[Term]
id: GO:0035455
name: response to interferon-alpha
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PMID:11356686]
synonym: "response to interferon alfa-n1" RELATED [GOC:sl]
synonym: "response to interferon alfa-n3" RELATED [GOC:sl]
synonym: "response to leukocyte interferon" EXACT [GOC:sl]
synonym: "response to lymphoblast interferon" EXACT [GOC:sl]
synonym: "response to lymphoblastoid interferon" EXACT [GOC:sl]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0035456
name: response to interferon-beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374]
synonym: "response to beta-1 interferon" RELATED [GOC:sl]
synonym: "response to fiblaferon" EXACT [GOC:sl]
synonym: "response to fibroblast interferon" EXACT [GOC:sl]
synonym: "response to interferon beta" EXACT [GOC:hp, PR:000008924]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0035457
name: cellular response to interferon-alpha
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl]
synonym: "cellular response to interferon alfa-n1" RELATED [GOC:sl]
synonym: "cellular response to interferon alfa-n3" RELATED [GOC:sl]
synonym: "cellular response to leukocyte interferon" EXACT [GOC:sl]
synonym: "cellular response to lymphoblast interferon" EXACT [GOC:sl]
synonym: "cellular response to lymphoblastoid interferon" EXACT [GOC:sl]
is_a: GO:0035455 ! response to interferon-alpha
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0035458
name: cellular response to interferon-beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl]
synonym: "cellular response to beta-1 interferon" RELATED [GOC:sl]
synonym: "cellular response to fiblaferon" EXACT [GOC:sl]
synonym: "cellular response to fibroblast interferon" EXACT [GOC:sl]
is_a: GO:0035456 ! response to interferon-beta
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0035459
name: vesicle cargo loading
namespace: biological_process
def: "The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle." [GOC:bf, GOC:lb]
synonym: "cargo loading into vesicle" EXACT []
synonym: "cargo selection" EXACT [GOC:vw]
is_a: GO:0006810 ! transport
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0035460
name: L-ascorbate 6-phosphate lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate." [PMID:18097099, PMID:20359483]
xref: RHEA:28803
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0035461
name: vitamin transmembrane transport
namespace: biological_process
def: "The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vitamin membrane transport" EXACT []
is_a: GO:0051180 ! vitamin transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0035462
name: determination of left/right asymmetry in diencephalon
namespace: biological_process
def: "The establishment of the diencephalon with respect to the left and right halves." [GOC:dgh, PMID:15084459]
is_a: GO:0035545 ! determination of left/right asymmetry in nervous system
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0035463
name: obsolete transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves." [GOC:dgh, GOC:signaling]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0035464
name: obsolete regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves." [GOC:dgh]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0035465
name: obsolete regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of the lateral plate mesoderm with respect to its left and right halves." [GOC:dgh, PMID:15084459]
comment: This term was made obsolete because it describes regulation of the nodal signaling pathway. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm.
synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
is_obsolete: true
consider: GO:0003140
consider: GO:0017015

[Term]
id: GO:0035469
name: determination of pancreatic left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism." [GOC:dgh, PMID:12702646]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0031016 ! pancreas development

[Term]
id: GO:0035470
name: positive regulation of vascular wound healing
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:rph]
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:0061043 ! regulation of vascular wound healing
is_a: GO:0090303 ! positive regulation of wound healing
relationship: positively_regulates GO:0061042 ! vascular wound healing

[Term]
id: GO:0035471
name: luteinizing hormone signaling pathway involved in ovarian follicle development
namespace: biological_process
def: "The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:bf]
synonym: "luteinizing hormone signalling pathway involved in ovarian follicle development" EXACT [GOC:mah]
is_a: GO:0042700 ! luteinizing hormone signaling pathway
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0035472
name: choriogonadotropin hormone receptor activity
namespace: molecular_function
def: "Combining with the choriogonadotropin hormone to initiate a change in cell activity." [GOC:bf, ISBN:0198506732, PMID:1922095]
synonym: "CG receptor activity" EXACT [ISBN:0198506732]
synonym: "chorio-gonadotrophin receptor activity" EXACT [ISBN:0198506732]
synonym: "chorionic gonadotropin hormone receptor" EXACT [ISBN:0198506732]
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0035473
name: lipase binding
namespace: molecular_function
def: "Binding to a lipase." [GOC:BHF]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035474
name: selective angioblast sprouting
namespace: biological_process
def: "The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel." [GOC:dgh, PMID:19815777]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0035475
name: angioblast cell migration involved in selective angioblast sprouting
namespace: biological_process
def: "The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations." [GOC:dgh, PMID:19815777]
is_a: GO:0035476 ! angioblast cell migration
relationship: part_of GO:0035474 ! selective angioblast sprouting

[Term]
id: GO:0035476
name: angioblast cell migration
namespace: biological_process
def: "The orderly movement of angioblasts, cells involved in blood vessel morphogenesis." [GOC:dgh, PMID:19815777]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0035477
name: regulation of angioblast cell migration involved in selective angioblast sprouting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting." [GOC:dgh, PMID:19815777]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:1901342 ! regulation of vasculature development
relationship: regulates GO:0035475 ! angioblast cell migration involved in selective angioblast sprouting

[Term]
id: GO:0035478
name: chylomicron binding
namespace: molecular_function
def: "Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE." [GOC:BHF, PMID:17403372]
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0035479
name: angioblast cell migration from lateral mesoderm to midline
namespace: biological_process
def: "The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature." [GOC:dgh, PMID:11861480]
is_a: GO:0035476 ! angioblast cell migration

[Term]
id: GO:0035480
name: obsolete regulation of Notch signaling pathway involved in heart induction
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003129
consider: GO:0008593

[Term]
id: GO:0035481
name: obsolete positive regulation of Notch signaling pathway involved in heart induction
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM.
synonym: "positive regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003129
consider: GO:0045747

[Term]
id: GO:0035482
name: gastric motility
namespace: biological_process
def: "The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum." [GOC:cy, ISBN:9781416032458, PMID:16139031]
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0035483
name: gastric emptying
namespace: biological_process
def: "The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:cy, ISBN:9781416032458]
is_a: GO:0035482 ! gastric motility

[Term]
id: GO:0035484
name: adenine/adenine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing an A/A mispair." [GOC:bf, GOC:jh]
synonym: "A/A mispair binding" EXACT [GOC:jh]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0035485
name: adenine/guanine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing an A/G mispair." [GOC:bf, GOC:jh]
synonym: "A/G mispair binding" EXACT [GOC:jh]
synonym: "G/A mispair binding" RELATED [GOC:bf]
synonym: "guanine-adenine mispair binding" EXACT [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0035486
name: cytosine/cytosine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a C/C mispair." [GOC:bf, GOC:jh]
synonym: "C/C mispair binding" EXACT [GOC:jh]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0035487
name: thymine/thymine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a T/T mispair." [GOC:bf, GOC:jh]
synonym: "T/T mispair binding" EXACT []
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0035488
name: cytosine/thymine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a C/T mispair." [GOC:bf, GOC:jh]
synonym: "C/T mispair binding" EXACT [GOC:jh]
synonym: "T/C mispair binding" EXACT [GOC:bf]
synonym: "thymine/cytosine mispair binding" EXACT [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0035489
name: guanine/guanine mispair binding
namespace: molecular_function
def: "Binding to a double-stranded DNA region containing a G/G mispair." [GOC:bf, GOC:jh]
synonym: "G/G mispair binding" EXACT [GOC:jh]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0035490
name: regulation of leukotriene production involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0002540 ! leukotriene production involved in inflammatory response

[Term]
id: GO:0035491
name: positive regulation of leukotriene production involved in inflammatory response
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf]
is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0002540 ! leukotriene production involved in inflammatory response

[Term]
id: GO:0035492
name: negative regulation of leukotriene production involved in inflammatory response
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf]
is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0002540 ! leukotriene production involved in inflammatory response

[Term]
id: GO:0035493
name: SNARE complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0006906 ! vesicle fusion

[Term]
id: GO:0035494
name: SNARE complex disassembly
namespace: biological_process
def: "The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877]
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0035495
name: regulation of SNARE complex disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
relationship: regulates GO:0035494 ! SNARE complex disassembly

[Term]
id: GO:0035496
name: lipopolysaccharide-1,5-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide." [PMID:11304545]
synonym: "LPS-1,5-galactosyltransferase activity" EXACT [PMID:11304545]
synonym: "UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase" EXACT [PMID:11304545]
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0035497
name: cAMP response element binding
namespace: molecular_function
def: "Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470]
synonym: "cAMP-responsive element binding" EXACT [PMID:2875459]
synonym: "CRE binding" EXACT [PMID:2900470]
synonym: "cyclic AMP response element binding" EXACT [PMID:2900470]
synonym: "cyclic-AMP response element binding" EXACT [PMID:2900470]
synonym: "cyclic-AMP-responsive element binding" EXACT [PMID:2875459]
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0035498
name: carnosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine)." [PMID:20097752]
synonym: "carnosine metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0035499
name: carnosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine)." [PMID:20097752]
synonym: "carnosine anabolism" EXACT []
synonym: "carnosine biosynthesis" EXACT []
synonym: "carnosine formation" EXACT []
synonym: "carnosine synthesis" EXACT []
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0035498 ! carnosine metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0035500
name: MH2 domain binding
namespace: molecular_function
def: "Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers." [GOC:curators]
synonym: "MAD homology 2 domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0035501
name: MH1 domain binding
namespace: molecular_function
def: "Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors." [Pfam:PF03165]
synonym: "MAD homology 1 domain binding" EXACT [Pfam:PF03165]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0035502
name: metanephric part of ureteric bud development
namespace: biological_process
def: "The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0003338 ! metanephros morphogenesis

[Term]
id: GO:0035503
name: ureter part of ureteric bud development
namespace: biological_process
def: "The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0072197 ! ureter morphogenesis

[Term]
id: GO:0035504
name: regulation of myosin light chain kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:0035505
name: positive regulation of myosin light chain kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0035504 ! regulation of myosin light chain kinase activity
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity

[Term]
id: GO:0035506
name: obsolete negative regulation of myosin light chain kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0035507
name: obsolete regulation of myosin-light-chain-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
is_obsolete: true

[Term]
id: GO:0035508
name: obsolete positive regulation of myosin-light-chain-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
is_obsolete: true

[Term]
id: GO:0035509
name: obsolete negative regulation of myosin-light-chain-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
is_obsolete: true

[Term]
id: GO:0035510
name: DNA dealkylation
namespace: biological_process
def: "The removal of an alkyl group from one or more nucleotides within an DNA molecule." [GOC:bf]
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0035511
name: obsolete oxidative DNA demethylation
namespace: biological_process
def: "OBSOLETE. Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035516

[Term]
id: GO:0035512
name: obsolete hydrolytic DNA demethylation
namespace: biological_process
def: "OBSOLETE. The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0051747

[Term]
id: GO:0035513
name: oxidative RNA demethylation
namespace: biological_process
def: "The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]
is_a: GO:0009451 ! RNA modification
is_a: GO:0070989 ! oxidative demethylation

[Term]
id: GO:0035514
name: DNA demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule." [GOC:bf]
is_a: GO:0032451 ! demethylase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0035515
name: oxidative RNA demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]
synonym: "2-oxoglutarate-dependent RNA demethylase" EXACT [PMID:17991826]
xref: Reactome:R-HSA-8857692 "RNA demethylases demethylate N6-methyladenosine RNA"
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0032451 ! demethylase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0035516
name: broad specificity oxidative DNA demethylase activity
namespace: molecular_function
alt_id: GO:0103051
alt_id: GO:0103052
alt_id: GO:0103053
def: "Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA." [PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299]
comment: This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system.
synonym: "1-ethyladenine demethylase activity" NARROW []
synonym: "2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826]
synonym: "5-formylcytosine dioxygenase activity" NARROW []
synonym: "5-hydroxymethylcytosine dioxygenase activity" NARROW []
synonym: "5fC dioxygenase" NARROW []
synonym: "5hmC dioxygenase" NARROW []
synonym: "N1-methyladenine demethylase activity" NARROW []
synonym: "N3-methylcytosine demethylase activity" NARROW []
synonym: "oxidative DNA demethylase activity" BROAD []
xref: EC:1.14.11.33
xref: MetaCyc:RXN-12353
xref: Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2"
xref: Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"
xref: RHEA:30299
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0035514 ! DNA demethylase activity

[Term]
id: GO:0035517
name: PR-DUB complex
namespace: cellular_component
def: "A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively." [PMID:20436459]
synonym: "Polycomb repressive deubiquitinase complex" EXACT [PMID:20436459]
is_a: GO:0031519 ! PcG protein complex

[Term]
id: GO:0035518
name: obsolete histone H2A monoubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group." [PMID:18206970]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0035519
name: protein K29-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation." [PMID:17028573]
synonym: "protein K29-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0035520
name: monoubiquitinated protein deubiquitination
namespace: biological_process
def: "The removal of the ubiquitin group from a monoubiquitinated protein." [GOC:bf]
synonym: "monoubiquitinated protein deubiquitinylation" EXACT []
synonym: "monoubiquitinated protein deubiquitylation" EXACT []
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0035521
name: obsolete monoubiquitinated histone deubiquitination
namespace: biological_process
def: "OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone protein." [GOC:bf, PMID:20436459]
comment: This term was obsoleted because it represents a molecular function.
synonym: "monoubiquitinated histone deubiquitinylation" EXACT []
synonym: "monoubiquitinated histone deubiquitylation" EXACT []
is_obsolete: true

[Term]
id: GO:0035522
name: obsolete monoubiquitinated histone H2A deubiquitination
namespace: biological_process
def: "OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]
comment: This term was obsoleted because it represents a molecular function.
synonym: "monoubiquitinated histone H2A deubiquitinylation" EXACT []
synonym: "monoubiquitinated histone H2A deubiquitylation" EXACT []
is_obsolete: true

[Term]
id: GO:0035523
name: protein K29-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein." [GOC:bf]
synonym: "protein K29-linked deubiquitinylation" EXACT []
synonym: "protein K29-linked deubiquitylation" EXACT []
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0035524
name: proline transmembrane transport
namespace: biological_process
def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "proline membrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0035525
name: NF-kappaB p50/p65 complex
namespace: cellular_component
def: "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584]
comment: Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.
synonym: "NF-kappa B1/p65 complex" EXACT [PMID:9299584]
synonym: "NF-kappa B1/RelA complex" EXACT [PMID:9299584]
synonym: "NF-kappa p105/p65 complex" RELATED [PMID:9299584]
synonym: "NF-kappa p105/RelA complex" RELATED [PMID:9299584]
synonym: "NF-kappa p50/RelA complex" EXACT [PMID:9299584]
is_a: GO:0071159 ! NF-kappaB complex

[Term]
id: GO:0035526
name: retrograde transport, plasma membrane to Golgi
namespace: biological_process
def: "The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles." [GOC:lb, PMID:17488291]
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0035527
name: 3-hydroxypropionate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH." [RHEA:26438]
synonym: "3-hydroxypropanoate dehydrogenase (NADP+) activity" EXACT []
synonym: "3-hydroxypropanoate:NADP+ oxidoreductase" RELATED [EC:1.1.1.298]
synonym: "3-hydroxypropionate:NADP+ oxidoreductase" RELATED [EC:1.1.1.298]
xref: EC:1.1.1.298
xref: KEGG_REACTION:R09289
xref: MetaCyc:RXN-8974
xref: RHEA:26438
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0035528
name: obsolete UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin." [GOC:bf]
comment: This term was obsoleted because it does not represent a specific pathway.
synonym: "UDP-GlcNAc biosynthesis involved in chitin biosynthesis" EXACT []
synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthesis" EXACT []
synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthetic process" EXACT []
synonym: "UDP-N-acetylglucosamine anabolism involved in chitin biosynthesis" EXACT []
synonym: "UDP-N-acetylglucosamine biosynthetic process involved in chitin biosynthetic process" EXACT []
synonym: "UDP-N-acetylglucosamine formation involved in chitin biosynthesis" EXACT []
synonym: "UDP-N-acetylglucosamine synthesis involved in chitin biosynthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0035529
name: NADH pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [PMID:12399474, PMID:20181750, RHEA:48868]
synonym: "NADH diphosphatase activity" EXACT []
synonym: "NADH pyrophosphohydrolase activity" EXACT []
xref: KEGG_REACTION:R00103
xref: MetaCyc:RXN0-4401
xref: Reactome:R-HSA-6809287 "NUDT12 hydrolyses NADH to NMNH"
xref: RHEA:48868
is_a: GO:0004551 ! dinucleotide phosphatase activity

[Term]
id: GO:0035530
name: chemokine (C-C motif) ligand 6 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, PMID:19812544]
subset: gocheck_do_not_annotate
synonym: "CCL6 production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0035531
name: regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
alt_id: GO:0035534
alt_id: GO:0035535
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "chemokine (C-C motif) ligand 6 secretion" NARROW []
synonym: "regulation of CCL6 production" EXACT []
synonym: "regulation of chemokine (C-C motif) ligand 6 secretion" NARROW []
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production

[Term]
id: GO:0035532
name: negative regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
alt_id: GO:0035536
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "negative regulation of CCL6 production" EXACT []
synonym: "negative regulation of chemokine (C-C motif) ligand 6 secretion" NARROW []
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
relationship: negatively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production

[Term]
id: GO:0035533
name: positive regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
alt_id: GO:0035537
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "positive regulation of CCL6 production" EXACT []
synonym: "positive regulation of chemokine (C-C motif) ligand 6 secretion" NARROW []
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
relationship: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production

[Term]
id: GO:0035538
name: carbohydrate response element binding
namespace: molecular_function
def: "Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes." [GOC:BHF, PMID:20001964]
synonym: "ChoRE binding" EXACT [PMID:20001964]
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0035539
name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA." [PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575]
synonym: "8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity" EXACT [PMID:17804481]
synonym: "8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity" EXACT [PMID:17804481]
synonym: "8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity" EXACT [PMID:7782328]
synonym: "8-oxo-dGTP pyrophosphohydrolase activity" EXACT [PMID:17804481]
synonym: "8-oxo-dGTPase activity" EXACT [PMID:7782328]
xref: EC:3.6.1.55
xref: Reactome:R-HSA-2395849 "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP"
xref: Reactome:R-HSA-2395869 "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP"
xref: Reactome:R-HSA-9750555 "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP"
xref: RHEA:31575
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0035540
name: positive regulation of SNARE complex disassembly
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0035495 ! regulation of SNARE complex disassembly
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0035494 ! SNARE complex disassembly

[Term]
id: GO:0035541
name: negative regulation of SNARE complex disassembly
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0035495 ! regulation of SNARE complex disassembly
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0035494 ! SNARE complex disassembly

[Term]
id: GO:0035542
name: regulation of SNARE complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0035493 ! SNARE complex assembly

[Term]
id: GO:0035543
name: positive regulation of SNARE complex assembly
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0035542 ! regulation of SNARE complex assembly
relationship: positively_regulates GO:0035493 ! SNARE complex assembly

[Term]
id: GO:0035544
name: negative regulation of SNARE complex assembly
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0035542 ! regulation of SNARE complex assembly
relationship: negatively_regulates GO:0035493 ! SNARE complex assembly

[Term]
id: GO:0035545
name: determination of left/right asymmetry in nervous system
namespace: biological_process
def: "The establishment of the nervous system with respect to the left and right halves." [GOC:kmv, PMID:17717195, PMID:19641012]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0035550
name: urease complex
namespace: cellular_component
def: "A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide)." [InterPro:IPR008221, PMID:2651866]
comment: Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes.
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0035551
name: obsolete protein initiator methionine removal involved in protein maturation
namespace: biological_process
def: "OBSOLETE. Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein." [GOC:bf, GOC:hjd, GOC:vw]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0035552
name: obsolete oxidative single-stranded DNA demethylation
namespace: biological_process
def: "OBSOLETE. Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698]
comment: This term was obsoleted because it represents a molecular function.
synonym: "oxidative ssDNA demethylation" EXACT []
is_obsolete: true
consider: GO:0035516

[Term]
id: GO:0035553
name: obsolete oxidative single-stranded RNA demethylation
namespace: biological_process
def: "OBSOLETE. Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698]
comment: This term was obsoleted because it represents a molecular function.
synonym: "oxidative ssRNA demethylation" EXACT []
is_obsolete: true
consider: GO:0035516

[Term]
id: GO:0035554
name: termination of Roundabout signal transduction
namespace: biological_process
def: "The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated." [GOC:BHF, GOC:vk]
is_a: GO:0023021 ! termination of signal transduction
is_a: GO:0035387 ! negative regulation of Roundabout signaling pathway
relationship: part_of GO:0035385 ! Roundabout signaling pathway

[Term]
id: GO:0035555
name: obsolete initiation of Roundabout signal transduction
namespace: biological_process
def: "OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO)." [GOC:vk]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "initiation of Roundabout signal transduction" EXACT []
is_obsolete: true
consider: GO:0035385
consider: GO:0038023
consider: GO:0048495

[Term]
id: GO:0035556
name: intracellular signal transduction
namespace: biological_process
alt_id: GO:0007242
alt_id: GO:0007243
alt_id: GO:0023013
alt_id: GO:0023034
def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
subset: goslim_drosophila
synonym: "intracellular signal transduction pathway" NARROW []
synonym: "intracellular signaling cascade" RELATED [GOC:signaling]
synonym: "intracellular signaling pathway" RELATED []
synonym: "signal transmission via intracellular cascade" NARROW []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0035557
name: obsolete intracellular signal transduction involved in cell surface receptor linked signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]
comment: This term was made obsolete because the syntax of the term is incorrect.
synonym: "intracellular signal transduction involved in cell surface receptor linked signaling" EXACT []
synonym: "intracellular signal transduction involved in cell surface receptor linked signalling" EXACT [GOC:mah]
synonym: "intracellular signaling cascade involved in cell surface receptor linked signaling" EXACT []
synonym: "intracellular signaling chain involved in cell surface receptor signaling" EXACT [ISBN:3527303782]
is_obsolete: true

[Term]
id: GO:0035558
name: obsolete phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:signaling]
comment: This term was made obsolete because the syntax of the term is incorrect.
synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling" EXACT []
synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signalling" EXACT []
synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signaling" EXACT []
synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signalling" EXACT [GOC:mah]
synonym: "PI3K cascade involved in signaling from the insulin receptor" EXACT []
is_obsolete: true
consider: GO:0008286

[Term]
id: GO:0035559
name: obsolete MAPKKK cascade involved in epidermal growth factor receptor signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling]
comment: This term was made obsolete because the syntax of the term is incorrect.
synonym: "MAPKKK cascade involved in epidermal growth factor receptor signaling" EXACT []
synonym: "MAPKKK cascade involved in epidermal growth factor receptor signalling" EXACT [GOC:mah]
synonym: "MAPKKK cascade involved in signaling from the EGFR" EXACT []
is_obsolete: true

[Term]
id: GO:0035560
name: pheophorbidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a." [PMID:16228561, RHEA:32483]
synonym: "phedase activity" RELATED [EC:3.1.1.82]
synonym: "pheophoridase activity" RELATED []
synonym: "PPD activity" RELATED [EC:3.1.1.82]
xref: EC:3.1.1.82
xref: RHEA:32483
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0035561
name: regulation of chromatin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0035562
name: negative regulation of chromatin binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0035561 ! regulation of chromatin binding
is_a: GO:0051100 ! negative regulation of binding

[Term]
id: GO:0035563
name: positive regulation of chromatin binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0035561 ! regulation of chromatin binding
is_a: GO:0051099 ! positive regulation of binding

[Term]
id: GO:0035564
name: regulation of kidney size
namespace: biological_process
def: "Any process that modulates the size of a kidney." [GOC:bf]
is_a: GO:0090066 ! regulation of anatomical structure size
relationship: part_of GO:0060993 ! kidney morphogenesis

[Term]
id: GO:0035565
name: regulation of pronephros size
namespace: biological_process
def: "Any process that modulates the size of a pronephric kidney." [GOC:bf]
synonym: "regulation of pronephric kidney size" EXACT [GOC:bf]
is_a: GO:0035564 ! regulation of kidney size
relationship: part_of GO:0072114 ! pronephros morphogenesis

[Term]
id: GO:0035566
name: regulation of metanephros size
namespace: biological_process
def: "Any process that modulates the size of a metanephric kidney." [GOC:bf]
synonym: "regulation of metanephric kidney size" EXACT [GOC:bf]
is_a: GO:0035564 ! regulation of kidney size
relationship: part_of GO:0003338 ! metanephros morphogenesis

[Term]
id: GO:0035567
name: non-canonical Wnt signaling pathway
namespace: biological_process
def: "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin." [PMID:37804416]
comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term.
synonym: "beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:signaling]
synonym: "non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0035568
name: N-terminal peptidyl-proline methylation
namespace: biological_process
def: "The methylation of the N-terminal proline of proteins." [PMID:20668449, RESID:AA0419]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0419
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0035569
name: obsolete N-terminal peptidyl-proline trimethylation
namespace: biological_process
def: "OBSOLETE. The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline." [PMID:20668449]
comment: This term was made obsolete because N-terminal proline residues cannot be trimethylated.
synonym: "N-terminal peptidyl-proline trimethylation" EXACT []
is_obsolete: true

[Term]
id: GO:0035570
name: N-terminal peptidyl-serine methylation
namespace: biological_process
def: "The methylation of the N-terminal serine of proteins." [PMID:20668449]
subset: gocheck_obsoletion_candidate
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0035571
name: obsolete N-terminal peptidyl-serine monomethylation
namespace: biological_process
def: "OBSOLETE. The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine." [PMID:20668449]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0035572
name: N-terminal peptidyl-serine dimethylation
namespace: biological_process
def: "The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine." [PMID:20668449]
subset: gocheck_obsoletion_candidate
is_a: GO:0035570 ! N-terminal peptidyl-serine methylation

[Term]
id: GO:0035573
name: N-terminal peptidyl-serine trimethylation
namespace: biological_process
def: "The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine." [PMID:20668449]
subset: gocheck_obsoletion_candidate
is_a: GO:0035570 ! N-terminal peptidyl-serine methylation

[Term]
id: GO:0035574
name: obsolete histone H4-K20 demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone." [GOC:sp, PMID:20622853]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035575

[Term]
id: GO:0035575
name: histone H4K20 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:20622853, PMID:26214369, PMID:32209475]
synonym: "histone demethylase activity (H4-K20 specific)" EXACT []
synonym: "histone demethylase activity (H4K20-specific)" EXACT []
synonym: "histone H4-K20 demethylase activity" EXACT []
synonym: "histone H4-methyl-lysine-20 demethylase activity" EXACT []
synonym: "histone H4K20me demethylase activity" EXACT []
xref: Reactome:R-HSA-2172678 "PHF8 demethylates histone H4K20me1"
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0141058 ! histone H4 demethylase activity

[Term]
id: GO:0035576
name: obsolete retinoic acid receptor signaling pathway involved in pronephric field specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop." [GOC:bf, PMID:16979153, PMID:19909807]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model.
synonym: "retinoic acid receptor signalling pathway involved in pronephric field specification" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0039003
consider: GO:0048384

[Term]
id: GO:0035577
name: azurophil granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095]
synonym: "primary granule membrane" EXACT []
is_a: GO:0005765 ! lysosomal membrane
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042582 ! azurophil granule

[Term]
id: GO:0035578
name: azurophil granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095]
synonym: "primary granule lumen" EXACT []
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042582 ! azurophil granule

[Term]
id: GO:0035579
name: specific granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549]
synonym: "secondary granule membrane" EXACT []
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042581 ! specific granule

[Term]
id: GO:0035580
name: specific granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549]
synonym: "secondary granule lumen" EXACT []
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042581 ! specific granule

[Term]
id: GO:0035581
name: sequestering of extracellular ligand from receptor
namespace: biological_process
def: "The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor." [GOC:BHF, GOC:signaling]
comment: Preventing a ligand from binding to its cell surface receptor be achieved by binding to the ligand directly, or by binding to members of a ligand-containing complex.
synonym: "extracellular sequestering of receptor ligand" EXACT [GOC:bf]
synonym: "negative regulation of protein bioavailability" RELATED [GOC:BHF]
is_a: GO:1900116 ! extracellular negative regulation of signal transduction

[Term]
id: GO:0035582
name: sequestering of BMP in extracellular matrix
namespace: biological_process
def: "Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins." [GOC:BHF, PMID:20855508]
comment: Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
synonym: "BMP sequestration in the ECM" EXACT [PMID:20855508]
synonym: "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" EXACT [GOC:bf]
synonym: "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" EXACT [GOC:mah]
synonym: "negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein" EXACT []
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
is_a: GO:0071694 ! maintenance of protein location in extracellular region

[Term]
id: GO:0035583
name: sequestering of TGFbeta in extracellular matrix
namespace: biological_process
def: "Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins." [GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508]
synonym: "negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:bf]
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:mah]
synonym: "sequestering of TGFbeta large latency complex in extracellular matrix" EXACT [PMID:12482908]
synonym: "sequestering of TGFbeta LLC in extracellular matrix" EXACT [PMID:12482908]
is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
is_a: GO:0071694 ! maintenance of protein location in extracellular region

[Term]
id: GO:0035584
name: obsolete calcium-mediated signaling using intracellular calcium source
namespace: biological_process
def: "OBSOLETE. The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754]
comment: The reason for obsoletion is that these pathways are not clearly defined and likely overlap with transport.
synonym: "calcium signaling using intracellular calcium source" EXACT []
synonym: "calcium signalling using intracellular calcium source" EXACT []
synonym: "calcium-mediated signalling using intracellular calcium source" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:1990034

[Term]
id: GO:0035585
name: obsolete calcium-mediated signaling using extracellular calcium source
namespace: biological_process
def: "OBSOLETE. The series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754]
comment: The reason for obsoletion is that these pathways are not clearly defined and likely overlap with transport.
synonym: "calcium signaling using extracellular calcium source" EXACT []
synonym: "calcium signalling using extracellular calcium source" EXACT []
synonym: "calcium-mediated signalling using extracellular calcium source" EXACT []
synonym: "extracellular calcium influx" NARROW [GOC:BHF]
is_obsolete: true
consider: GO:0007165
consider: GO:1990034

[Term]
id: GO:0035588
name: G protein-coupled purinergic receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by an extracellular purine or purine derivative binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:BHF, PMID:9755289]
synonym: "G-protein coupled purinergic receptor signaling pathway" EXACT []
synonym: "G-protein coupled purinergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway

[Term]
id: GO:0035589
name: G protein-coupled purinergic nucleotide receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:BHF, PMID:9755289]
synonym: "G-protein coupled purinergic nucleotide receptor signaling pathway" EXACT []
synonym: "G-protein coupled purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah]
synonym: "P2Y receptor signaling pathway" EXACT [PMID:9755289]
is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway

[Term]
id: GO:0035590
name: purinergic nucleotide receptor signaling pathway
namespace: biological_process
alt_id: GO:0035587
def: "The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:9755289]
synonym: "P2 receptor signaling pathway" RELATED [PMID:9755289]
synonym: "purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah]
synonym: "purinergic receptor signaling pathway" RELATED []
synonym: "purinergic receptor signalling pathway" RELATED [GOC:mah]
synonym: "purinoceptor signaling pathway" RELATED [PMID:9755289]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0035591
name: signaling adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]
comment: A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498).
synonym: "signaling protein recruiting activity" EXACT []
synonym: "signaling scaffold activity" RELATED []
synonym: "signalling adaptor activity" EXACT [GOC:mah]
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0035592
name: establishment of protein localization to extracellular region
namespace: biological_process
def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF]
synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "establishment of protein localization in extracellular region" EXACT []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071692 ! protein localization to extracellular region

[Term]
id: GO:0035593
name: obsolete positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region." [GOC:BHF, PMID:19906850]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of Wnt diffusion" NARROW [PMID:19906850]
synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region" EXACT []
synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region" EXACT [GOC:mah]
synonym: "positive regulation of Wnt signaling range" RELATED [PMID:19906850]
synonym: "positive regulation of Wnt-activated signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0030177

[Term]
id: GO:0035594
name: ganglioside binding
namespace: molecular_function
def: "Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues." [GOC:yaf]
is_a: GO:0043208 ! glycosphingolipid binding
is_a: GO:0097001 ! ceramide binding

[Term]
id: GO:0035595
name: N-acetylglucosaminylinositol deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol." [RHEA:26180]
synonym: "1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity" RELATED [EC:3.5.1.103]
synonym: "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity" RELATED [EC:3.5.1.103]
synonym: "GlcNAc-Ins deacetylase activity" EXACT [GOC:rs]
synonym: "N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity" RELATED [EC:3.5.1.103]
xref: EC:3.5.1.103
xref: KEGG_REACTION:R09651
xref: MetaCyc:RXN1G-2
xref: RHEA:26180
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0035596
name: methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor." [GOC:jh2, PMID:20472640]
synonym: "MTTase" EXACT [PMID:20472640]
is_a: GO:0050497 ! alkylthioltransferase activity

[Term]
id: GO:0035597
name: N6-isopentenyladenosine methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)." [PMID:20472640]
synonym: "i6A methylthiotransferase activity" EXACT [PMID:20472640]
is_a: GO:0035596 ! methylthiotransferase activity

[Term]
id: GO:0035598
name: N6-threonylcarbomyladenosine methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)." [PMID:20472640, PMID:20584901]
synonym: "t6A methylthiotransferase activity" EXACT [PMID:20472640]
xref: Reactome:R-HSA-6786571 "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37"
is_a: GO:0035596 ! methylthiotransferase activity

[Term]
id: GO:0035599
name: aspartic acid methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid." [PMID:18252828, PMID:8844851, RESID:AA0232]
comment: Note that peptidyl-L-beta-methylthioaspartic acid is typical of bacterial ribosomal protein S12.
xref: RESID:AA0232
is_a: GO:0035596 ! methylthiotransferase activity

[Term]
id: GO:0035600
name: tRNA methylthiolation
namespace: biological_process
def: "The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0035601
name: protein deacylation
namespace: biological_process
def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid deacylation" EXACT [GOC:se]
is_a: GO:0036211 ! protein modification process
is_a: GO:0098732 ! macromolecule deacylation

[Term]
id: GO:0035602
name: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mtg_apoptosis, GOC:yaf]
synonym: "FGF receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" NARROW []
synonym: "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow" EXACT []
synonym: "fibroblast growth factor receptor signalling pathway involved in negative regulation of apoptotic process in bone marrow" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0071866 ! negative regulation of apoptotic process in bone marrow cell

[Term]
id: GO:0035603
name: fibroblast growth factor receptor signaling pathway involved in hemopoiesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis." [GOC:yaf]
synonym: "FGF receptor signaling pathway involved in hematopoiesis" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in hematopoiesis" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signaling pathway involved in hematopoiesis" EXACT [GOC:yaf]
synonym: "fibroblast growth factor receptor signalling pathway involved in hemopoiesis" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0035604
name: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:yaf]
synonym: "FGF receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signalling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0071864 ! positive regulation of cell proliferation in bone marrow

[Term]
id: GO:0035605
name: peptidyl-cysteine S-nitrosylase activity
namespace: molecular_function
def: "Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein." [GOC:sp, PMID:20972425, PMID:20972426]
comment: This term should not be used to annotate the nitrosylating action of nitric oxide synthase (NOS) if the nitroso group is synthesized directly on the substrate.
synonym: "protein nitrosylase activity" RELATED [GOC:sp]
synonym: "S-nitrosylase activity" EXACT [PMID:20972426]
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0035606
name: peptidyl-cysteine S-trans-nitrosylation
namespace: biological_process
def: "Transfer of a nitric oxide (NO) group from one cysteine residue to another." [PMID:19854201, PMID:20972425, PMID:20972426]
subset: gocheck_obsoletion_candidate
synonym: "cysteine to cysteine nitrosylation" EXACT [PMID:20972426]
synonym: "cysteine-to-cysteine transnitrosylation" EXACT [PMID:20972426]
synonym: "protein-to-protein transnitrosylation" BROAD [PMID:20972426]
synonym: "S-transnitrosylation" EXACT [PMID:20972426]
is_a: GO:0018119 ! peptidyl-cysteine S-nitrosylation

[Term]
id: GO:0035607
name: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state." [GOC:yaf]
synonym: "FGF receptor signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021769 ! orbitofrontal cortex development

[Term]
id: GO:0035608
name: protein deglutamylation
namespace: biological_process
def: "The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation." [GOC:sp, PMID:21074048]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid deglutamylation" EXACT [GOC:bf]
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0035609
name: C-terminal protein deglutamylation
namespace: biological_process
def: "The removal of a C-terminal, gene-encoded glutamate residue from a protein." [GOC:sp, PMID:21074048]
subset: gocheck_obsoletion_candidate
synonym: "protein primary sequence deglutamylation" EXACT [PMID:21074048]
is_a: GO:0018410 ! C-terminal protein amino acid modification
is_a: GO:0035608 ! protein deglutamylation

[Term]
id: GO:0035610
name: protein side chain deglutamylation
namespace: biological_process
def: "The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048]
subset: gocheck_obsoletion_candidate
synonym: "removal of posttranslational polyglutamylation" EXACT [PMID:21074048]
synonym: "shortening of glutamate side chain" RELATED [PMID:21074048]
is_a: GO:0035608 ! protein deglutamylation

[Term]
id: GO:0035611
name: protein branching point deglutamylation
namespace: biological_process
def: "The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue." [GOC:sp, PMID:21074048]
subset: gocheck_obsoletion_candidate
is_a: GO:0035608 ! protein deglutamylation

[Term]
id: GO:0035612
name: AP-2 adaptor complex binding
namespace: molecular_function
def: "Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499]
synonym: "AP-2 clathrin adaptor complex binding" RELATED [GOC:bf]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0035613
name: RNA stem-loop binding
namespace: molecular_function
def: "Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]
synonym: "RNA hairpin binding" EXACT [PMID:16568238]
synonym: "RNA hairpin loop binding" EXACT [PMID:16568238]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0035614
name: snRNA stem-loop binding
namespace: molecular_function
def: "Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]
synonym: "small nuclear RNA stem-loop binding" EXACT []
synonym: "snRNA hairpin binding" EXACT [PMID:16568238]
synonym: "snRNA hairpin loop binding" EXACT [PMID:16568238]
is_a: GO:0017069 ! snRNA binding
is_a: GO:0035613 ! RNA stem-loop binding

[Term]
id: GO:0035615
name: clathrin adaptor activity
namespace: molecular_function
def: "Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]
synonym: "clathrin-associated adaptor activity" EXACT [PMID:15728179]
is_a: GO:0140312 ! cargo adaptor activity

[Term]
id: GO:0035616
name: obsolete histone H2B conserved C-terminal lysine deubiquitination
namespace: biological_process
def: "OBSOLETE. A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:bf, GOC:vw, PMID:15657442]
comment: This term was obsoleted because it represents a molecular function.
synonym: "budding yeast H2B K123 deubiquitination" NARROW [GOC:vw]
synonym: "fission yeast H2B K119 deubiquitination" NARROW [GOC:vw]
synonym: "mammalian H2B K120 deubiquitination" NARROW [GOC:vw]
is_obsolete: true

[Term]
id: GO:0035617
name: stress granule disassembly
namespace: biological_process
def: "The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938]
synonym: "SG disassembly" EXACT [PMID:19825938]
is_a: GO:0032988 ! protein-RNA complex disassembly
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0035618
name: root hair
namespace: cellular_component
def: "A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall." [PMID:24982600, PO:0000256]
comment: This term is a child of 'cell projection' and not 'cell hair' to distinguish it from animal cell hairs, which are morphologically distinct.
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0035619
name: root hair tip
namespace: cellular_component
def: "The tip portion of an outgrowth of a root epidermal cell." [PMID:16567499]
synonym: "root hair cell tip" EXACT []
is_a: GO:0051286 ! cell tip
relationship: part_of GO:0035618 ! root hair

[Term]
id: GO:0035621
name: ER to Golgi ceramide transport
namespace: biological_process
def: "The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229]
synonym: "endoplasmic reticulum to Golgi ceramide transport" EXACT [GOC:bf]
synonym: "ER to Golgi ceramide translocation" EXACT [PMID:14685229]
synonym: "non-vesicular ceramide trafficking" EXACT [PMID:14685229]
is_a: GO:0032365 ! intracellular lipid transport
is_a: GO:0035627 ! ceramide transport

[Term]
id: GO:0035622
name: intrahepatic bile duct development
namespace: biological_process
def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624]
synonym: "IHBD development" EXACT [PMID:20614624]
synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624]
is_a: GO:0061009 ! common bile duct development
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0035623
name: renal D-glucose absorption
namespace: biological_process
def: "A renal system process in which D-glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:yaf, PMID:11269503]
synonym: "glucose reabsorption" EXACT [GOC:yaf]
synonym: "nephron glucose absorption" EXACT [GOC:yaf]
synonym: "renal glucose absorption" EXACT []
is_a: GO:0070293 ! renal absorption
is_a: GO:1904659 ! D-glucose transmembrane transport

[Term]
id: GO:0035624
name: receptor transactivation
namespace: biological_process
def: "The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer." [GOC:al, GOC:bf, GOC:BHF, PMID:16870826, PMID:21063387]
subset: gocheck_do_not_annotate
is_a: GO:2000273 ! positive regulation of signaling receptor activity

[Term]
id: GO:0035625
name: obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. The process in which an epidermal growth factor-activated receptor is activated via signaling events from a consequence of a G protein-coupled . This is an example of cross-talk between the EGF and GPCR signaling pathways." [GOC:bf, GOC:BHF, PMID:10622253, PMID:17655843]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
synonym: "EGFR transactivation by GPCR" EXACT [GOC:bf]
synonym: "EGFR transactivation upon GPCR stimulation" EXACT [PMID:10622253]
synonym: "epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway" EXACT [GOC:bf, GOC:signaling]
synonym: "epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signalling pathway" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0035626
name: juvenile hormone mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a juvenile hormone binding to its receptor, a bHLH-PAS transcription factor, to regulate gene expression." [PMID:28285758, PMID:29888456]
synonym: "juvenile hormone mediated signalling pathway" EXACT [GOC:bf]
synonym: "juvenile hormone-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0030522 ! intracellular receptor signaling pathway

[Term]
id: GO:0035627
name: ceramide transport
namespace: biological_process
def: "The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart]
is_a: GO:0006869 ! lipid transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0035628
name: cystic duct development
namespace: biological_process
def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct." [PMID:20614624]
is_a: GO:0061009 ! common bile duct development

[Term]
id: GO:0035629
name: obsolete N-terminal protein amino acid N-linked glycosylation
namespace: biological_process
def: "OBSOLETE. Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein." [GOC:bf, GOC:pr]
comment: The reason for obsoletion is that these term were added in error.
is_obsolete: true
replaced_by: GO:0006487

[Term]
id: GO:0035630
name: bone mineralization involved in bone maturation
namespace: biological_process
def: "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state." [GOC:bf, GOC:BHF]
comment: Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'.
is_a: GO:0030282 ! bone mineralization
relationship: part_of GO:0043931 ! ossification involved in bone maturation

[Term]
id: GO:0035631
name: CD40 receptor complex
namespace: cellular_component
def: "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0035632
name: mitochondrial prohibitin complex
namespace: cellular_component
def: "A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death." [GOC:kmv, PMID:12237468, PMID:21164222]
synonym: "mitochondrial inner membrane prohibitin complex" EXACT [GOC:bf]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:0035633
name: maintenance of blood-brain barrier
namespace: biological_process
def: "Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation." [GOC:aruk, GOC:bc, GOC:bf, GOC:sl, PMID:20080302, PMID:30280653]
comment: Homeostasis and maintenance processes are regulatory processes, therefore, regulation child terms, such as: regulation of maintenance of blood-brain barrier, should not exist for these terms. \nInstead, for capturing regulation at the blood-brain barrier, consider using the part_of child term: regulation of blood-brain barrier permeability.
synonym: "maintenance of BBB" EXACT []
synonym: "maintenance of blood/brain barrier" EXACT []
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0035634
name: response to stilbenoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones." [GOC:yaf, Wikipedia:Stilbenoid]
subset: goslim_chembl
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0035635
name: entry of bacterium into host cell
namespace: biological_process
def: "The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:21187937]
synonym: "bacterial entry into host cell" EXACT [GOC:bf]
synonym: "invasion of bacteria into host cell" EXACT [GOC:bf]
is_a: GO:0044409 ! symbiont entry into host

[Term]
id: GO:0035636
name: obsolete multi-organism signaling
namespace: biological_process
def: "OBSOLETE. The transfer of information between living organisms." [GOC:go_curators]
comment: This term was obsoleted because it was a grouping term but had no subclasses.
synonym: "multi-organism signalling" EXACT [GOC:bf]
synonym: "pheromone signaling" NARROW [GOC:bf]
synonym: "signaling between organisms" EXACT [GOC:bf]
synonym: "signaling with other organism" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035637
name: obsolete multicellular organismal signaling
namespace: biological_process
def: "OBSOLETE. The transfer of information occurring at the level of a multicellular organism." [GOC:go_curators]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "multicellular organismal signalling" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035639
name: purine ribonucleoside triphosphate binding
namespace: molecular_function
def: "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732]
synonym: "purine NTP binding" BROAD [GOC:ebc]
is_a: GO:0043168 ! anion binding
is_a: GO:1901265 ! nucleoside phosphate binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0035640
name: exploration behavior
namespace: biological_process
def: "The specific behavior of an organism in response to a novel environment or stimulus." [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169]
comment: For changes in locomotory behavior upon introduction to a novel environment, consider instead the child term: locomotory exploration behavior ; GO:0035641.
synonym: "exploration behaviour" EXACT [GOC:bf]
synonym: "exploratory behavior" EXACT [PMID:20869398]
synonym: "exploratory behaviour" EXACT [PMID:11682103]
synonym: "open-field behavior" NARROW [PMID:11682103]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0035641
name: locomotory exploration behavior
namespace: biological_process
def: "The specific movement from place to place of an organism in response to a novel environment." [GOC:sart, PMID:17151232]
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0035640 ! exploration behavior

[Term]
id: GO:0035642
name: histone H3R17 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to the arginine residue at position 17 of histone H3." [GOC:sp, PMID:11341840]
synonym: "histone methylase activity (H3-R17 specific)" EXACT [GOC:bf]
synonym: "histone methyltransferase activity (H3-R17 specific)" EXACT []
synonym: "histone-arginine N-methyltransferase activity (H3-R17 specific)" EXACT [GOC:bf]
synonym: "histone-H3R17 methyltransferase activity" EXACT []
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0035643
name: L-DOPA receptor activity
namespace: molecular_function
def: "Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine." [PMID:18828673, Wikipedia:L-DOPA]
synonym: "L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity" EXACT []
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0035644
name: phosphoanandamide dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from a phosphorylated anandamide." [GOC:BHF, PMID:16938887]
is_a: GO:0016311 ! dephosphorylation

[Term]
id: GO:0035645
name: enteric smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF]
synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0035646
name: endosome to melanosome transport
namespace: biological_process
def: "The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle." [PMID:16162817]
is_a: GO:0043485 ! endosome to pigment granule transport

[Term]
id: GO:0035647
name: obsolete 3-oxo-delta(4,5)-steroid 5-beta-reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H+ = a 5-beta-3-oxo-steroid + NADP+." [GOC:kad, MetaCyc:RXN-9726, PMID:19166903]
comment: The reason for obsoletion is that this term is equivalent to GO:0047787 delta4-3-oxosteroid 5beta-reductase activity.
synonym: "3-oxo-delta4,5-steroid 5beta-reductase" EXACT [GOC:kad]
is_obsolete: true
replaced_by: GO:0047787

[Term]
id: GO:0035648
name: circadian mating behavior
namespace: biological_process
def: "The fluctuation in mating behavior that occurs over an approximately 24 hour cycle." [GOC:bf, GOC:dos, PMID:11470898, PMID:17276917]
synonym: "circadian mating behaviour" EXACT [GOC:bf]
synonym: "circadian mating rhythm" EXACT [GOC:dos]
is_a: GO:0007617 ! mating behavior
is_a: GO:0048512 ! circadian behavior

[Term]
id: GO:0035649
name: Nrd1 complex
namespace: cellular_component
def: "A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p." [GOC:jh, PMID:10655211, PMID:16427013, PMID:21084293]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0035650
name: AP-1 adaptor complex binding
namespace: molecular_function
def: "Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [PMID:21097499]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0035651
name: AP-3 adaptor complex binding
namespace: molecular_function
def: "Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [PMID:21097499]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0035652
name: clathrin-coated vesicle cargo loading
namespace: biological_process
def: "Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle." [GOC:lb, PMID:16162817]
synonym: "cargo loading into clathrin-coated vesicle" EXACT []
is_a: GO:0035459 ! vesicle cargo loading

[Term]
id: GO:0035653
name: clathrin-coated vesicle cargo loading, AP-1-mediated
namespace: biological_process
def: "Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking." [GOC:lb, PMID:12802059, PMID:16162817]
synonym: "cargo loading into clathrin-coated vesicle, AP-1-mediated" EXACT []
is_a: GO:0035652 ! clathrin-coated vesicle cargo loading

[Term]
id: GO:0035654
name: clathrin-coated vesicle cargo loading, AP-3-mediated
namespace: biological_process
def: "Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle." [GOC:lb, PMID:12802059, PMID:16162817]
synonym: "cargo loading into clathrin-coated vesicle, AP-3-mediated" EXACT []
is_a: GO:0035652 ! clathrin-coated vesicle cargo loading

[Term]
id: GO:0035655
name: interleukin-18-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:signaling]
synonym: "interleukin-18-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071351 ! cellular response to interleukin-18

[Term]
id: GO:0035656
name: obsolete kinesin-associated melanosomal adaptor activity
namespace: molecular_function
def: "OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes." [PMID:19841138]
comment: This term was obsoleted because it represents the function of a specific protein.
synonym: "kinesin-melanosome adaptor activity" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0008093
consider: GO:0030674

[Term]
id: GO:0035657
name: eRF1 methyltransferase complex
namespace: cellular_component
def: "A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p." [GOC:rb, PMID:17008308, PMID:20400505]
synonym: "eRF1 MTase complex" EXACT [PMID:17008308]
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0035658
name: Mon1-Ccz1 complex
namespace: cellular_component
def: "A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862]
is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0035659
name: obsolete Wnt signaling pathway involved in wound healing, spreading of epidermal cells
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells" EXACT []
synonym: "Wnt receptor signalling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0016055
consider: GO:0042060

[Term]
id: GO:0035660
name: MyD88-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834, PMID:20385024]
synonym: "MyD88-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "MyD88-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0035661
name: MyD88-dependent toll-like receptor 2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response." [GOC:BHF, PMID:20385024]
synonym: "MyD88-dependent TLR2 signaling pathway" EXACT [GOC:bf]
synonym: "MyD88-dependent toll-like receptor 2 signalling pathway" EXACT [GOC:bf]
is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway
is_a: GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0035662
name: Toll-like receptor 4 binding
namespace: molecular_function
def: "Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834]
synonym: "TLR4 binding" EXACT [GOC:bf]
is_a: GO:0035325 ! Toll-like receptor binding

[Term]
id: GO:0035663
name: Toll-like receptor 2 binding
namespace: molecular_function
def: "Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response." [GOC:BHF]
synonym: "TLR2 binding" EXACT [GOC:bf]
is_a: GO:0035325 ! Toll-like receptor binding

[Term]
id: GO:0035664
name: TIRAP-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response." [GOC:BHF, PMID:11526399, PMID:11544529, PMID:12447442]
synonym: "MAL-dependent toll-like receptor signaling pathway" EXACT [PMID:11544529]
synonym: "MyD88 adapter-like dependent toll-like receptor signaling pathway" EXACT [PMID:11544529]
synonym: "TIRAP-dependent TLR signaling pathway" EXACT [GOC:bf]
synonym: "TIRAP-dependent toll-like receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0035665
name: TIRAP-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:12447441]
synonym: "MAL-dependent toll-like receptor 4 signaling pathway" EXACT [PMID:11544529]
synonym: "MyD88 adapter-like dependent toll-like receptor 4 signaling pathway" EXACT [GOC:11544529]
synonym: "TIRAP-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "TIRAP-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway
is_a: GO:0035664 ! TIRAP-dependent toll-like receptor signaling pathway

[Term]
id: GO:0035666
name: TRIF-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response." [GOC:BHF, PMID:12855817]
synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway" EXACT [PMID:12855817]
synonym: "TRIF-dependent TLR signaling pathway" EXACT [GOC:bf]
synonym: "TRIF-dependent toll-like receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0035667
name: TRIF-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18641322, PMID:20511708]
synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway" EXACT [PMID:12855817]
synonym: "TRIF-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "TRIF-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway
is_a: GO:0035666 ! TRIF-dependent toll-like receptor signaling pathway

[Term]
id: GO:0035668
name: TRAM-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response." [GOC:BHF, PMID:14556004]
synonym: "TRAM-dependent TLR signaling pathway" EXACT [GOC:bf]
synonym: "TRAM-dependent toll-like receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0035669
name: TRAM-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:14556004, PMID:18297073]
synonym: "TRAM-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "TRAM-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway
is_a: GO:0035668 ! TRAM-dependent toll-like receptor signaling pathway

[Term]
id: GO:0035670
name: plant-type ovary development
namespace: biological_process
def: "The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed." [GOC:bf, GOC:tb, ISBN:0879015322]
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0035671
name: enone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+." [GOC:kad, PMID:17945329, PMID:19166903]
xref: MetaCyc:RXN-12267
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0035672
name: oligopeptide transmembrane transport
namespace: biological_process
def: "The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "oligopeptide membrane transport" EXACT []
is_a: GO:0006857 ! oligopeptide transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0035673
name: oligopeptide transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015198
def: "Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732]
synonym: "oligopeptide transporter activity" RELATED []
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0035674
name: tricarboxylic acid transmembrane transport
namespace: biological_process
def: "The process in which a tricarboxylic acid is transported across a membrane." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "tricarboxylic acid membrane transport" EXACT []
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0035675
name: neuromast hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0000856]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0048886 ! neuromast hair cell differentiation

[Term]
id: GO:0035676
name: anterior lateral line neuromast hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509, ISBN:0387968377]
is_a: GO:0035675 ! neuromast hair cell development
relationship: part_of GO:0048903 ! anterior lateral line neuromast hair cell differentiation

[Term]
id: GO:0035677
name: posterior lateral line neuromast hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509]
is_a: GO:0035675 ! neuromast hair cell development
relationship: part_of GO:0048923 ! posterior lateral line neuromast hair cell differentiation

[Term]
id: GO:0035678
name: neuromast hair cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [CL:0000856]
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0035675 ! neuromast hair cell development

[Term]
id: GO:0035679
name: anterior lateral line neuromast hair cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509, ISBN:0387968377]
is_a: GO:0035678 ! neuromast hair cell morphogenesis
relationship: part_of GO:0035676 ! anterior lateral line neuromast hair cell development

[Term]
id: GO:0035680
name: posterior lateral line neuromast hair cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509]
is_a: GO:0035678 ! neuromast hair cell morphogenesis
relationship: part_of GO:0035677 ! posterior lateral line neuromast hair cell development

[Term]
id: GO:0035681
name: toll-like receptor 15 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 15." [GOC:pde]
synonym: "TLR15 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
is_a: GO:0140895 ! cell surface toll-like receptor signaling pathway

[Term]
id: GO:0035682
name: toll-like receptor 21 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to toll-like receptor 21." [GOC:pde]
synonym: "TLR21 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0035683
name: memory T cell extravasation
namespace: biological_process
def: "The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [CL:0000813, GOC:BHF]
synonym: "memory T-cell extravasation" EXACT [GOC:ebc]
is_a: GO:0072683 ! T cell extravasation

[Term]
id: GO:0035684
name: helper T cell extravasation
namespace: biological_process
def: "The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells." [CL:0000912, GOC:BHF]
synonym: "helper T-cell extravasation" EXACT [GOC:ebc]
synonym: "T-helper cell extravasation" EXACT [CL:0000912]
is_a: GO:0072683 ! T cell extravasation

[Term]
id: GO:0035685
name: helper T cell diapedesis
namespace: biological_process
def: "The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [CL:0000912, GOC:BHF]
synonym: "helper T-cell diapedesis" EXACT [CL:0000912]
synonym: "T-helper cell diapedesis" EXACT [CL:0000912]
is_a: GO:0050904 ! diapedesis
is_a: GO:0072678 ! T cell migration
relationship: part_of GO:0035684 ! helper T cell extravasation

[Term]
id: GO:0035686
name: sperm fibrous sheath
namespace: cellular_component
def: "A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat." [GOC:BHF, GOC:cilia, GOC:krc, PMID:20731842, PMID:3282552]
synonym: "flagellar fibrous sheath" EXACT []
synonym: "flagellum fibrous sheath" EXACT [GOC:bf]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0036126 ! sperm flagellum

[Term]
id: GO:0035687
name: T-helper 1 cell extravasation
namespace: biological_process
def: "The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF]
synonym: "Th1 cell extravasation" EXACT [CL:0000545]
is_a: GO:0035684 ! helper T cell extravasation
is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation

[Term]
id: GO:0035688
name: T-helper 1 cell diapedesis
namespace: biological_process
def: "The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF, PMID:10477596]
synonym: "Th1 cell diapedesis" EXACT [CL:0000545]
is_a: GO:0035685 ! helper T cell diapedesis
relationship: part_of GO:0035687 ! T-helper 1 cell extravasation

[Term]
id: GO:0035689
name: chemokine (C-C motif) ligand 5 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by chemokine CCL5 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:18337562]
synonym: "CCL5-mediated signaling pathway" EXACT [PMID:18337562]
synonym: "chemokine (C-C motif) ligand 5 signalling pathway" EXACT [GOC:mah]
synonym: "RANTES-mediated signaling pathway" EXACT [PMID:19122644]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0035691
name: macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by macrophage migration inhibitory factor binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:12782713, PMID:19413900]
synonym: "macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "MIF signaling pathway" EXACT [GOC:ebc]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0035692
name: macrophage migration inhibitory factor receptor complex
namespace: cellular_component
def: "A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins." [GOC:BHF, PMID:12782713, PMID:17045821]
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0035693
name: NOS2-CD74 complex
namespace: cellular_component
def: "A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases." [GOC:BHF, PMID:18003616]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0035694
name: mitochondrial protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228]
synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf]
synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf]
is_a: GO:0030163 ! protein catabolic process
relationship: part_of GO:0007005 ! mitochondrion organization

[Term]
id: GO:0035695
name: mitophagy by internal vacuole formation
namespace: biological_process
def: "The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228]
comment: In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome.
synonym: "MIV-mediated mitophagy" NARROW [PMID:21264228]
is_a: GO:0000422 ! autophagy of mitochondrion

[Term]
id: GO:0035696
name: monocyte extravasation
namespace: biological_process
def: "The migration of a monocyte from the blood vessels into the surrounding tissue." [CL:0000576, GOC:BHF, PMID:10657654]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:0071674 ! mononuclear cell migration
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0035697
name: CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue." [CL:0000625, GOC:BHF]
is_a: GO:0072683 ! T cell extravasation

[Term]
id: GO:0035698
name: CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue." [CL:0000794, GOC:BHF]
is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation

[Term]
id: GO:0035699
name: T-helper 17 cell extravasation
namespace: biological_process
def: "The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue." [CL:0000899, GOC:BHF]
is_a: GO:0035684 ! helper T cell extravasation
is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation

[Term]
id: GO:0035700
name: astrocyte chemotaxis
namespace: biological_process
def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471]
is_a: GO:0043615 ! astrocyte cell migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0035701
name: hematopoietic stem cell migration
namespace: biological_process
def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092]
synonym: "hemopoietic stem cell migration" EXACT [CL:0000037]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0035702
name: monocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716]
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0035703
name: monocyte migration into blood stream
namespace: biological_process
def: "The movement of a monocyte from the bone marrow to the blood stream." [CL:0000576, GOC:BHF]
synonym: "release of monocytes into circulation" EXACT [GOC:bf]
is_a: GO:0071674 ! mononuclear cell migration
is_a: GO:0097529 ! myeloid leukocyte migration
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0035704
name: helper T cell chemotaxis
namespace: biological_process
def: "The directed movement of a helper T cell in response to an external stimulus." [CL:0000912, GOC:BHF]
synonym: "T-helper cell chemotaxis" EXACT [CL:0000912]
is_a: GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0035705
name: T-helper 17 cell chemotaxis
namespace: biological_process
def: "The directed movement of a T-helper 17 cell in response to an external stimulus." [CL:0000899, GOC:BHF]
synonym: "Th17 cell chemotaxis" EXACT [CL:0000899]
is_a: GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0035706
name: T-helper 1 cell chemotaxis
namespace: biological_process
def: "The directed movement of a T-helper 1 cell in response to an external stimulus." [CL:0000545, GOC:BHF]
synonym: "Th1 cell chemotaxis" EXACT [CL:0000545]
is_a: GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0035707
name: T-helper 2 cell chemotaxis
namespace: biological_process
def: "The directed movement of a T-helper 2 cell in response to an external stimulus." [CL:0000546, GOC:BHF]
synonym: "Th2 cell chemotaxis" EXACT [CL:0000546]
is_a: GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0035708
name: interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4)." [GOC:BHF, PMID:12496423]
synonym: "IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:add, GOC:bf]
is_a: GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0035709
name: memory T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000813, GOC:BHF]
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0035710
name: CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000624, GOC:BHF]
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0035711
name: T-helper 1 cell activation
namespace: biological_process
def: "The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000545, GOC:BHF]
synonym: "Th1 cell activation" EXACT [CL:0000545]
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation

[Term]
id: GO:0035712
name: T-helper 2 cell activation
namespace: biological_process
def: "The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000546, GOC:BHF]
synonym: "Th2 cell activation" EXACT [CL:0000546]
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation

[Term]
id: GO:0035713
name: response to nitrogen dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [GOC:BHF]
synonym: "response to NO2" EXACT []
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0035714
name: cellular response to nitrogen dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [GOC:BHF]
synonym: "cellular response to NO2" EXACT []
is_a: GO:0035713 ! response to nitrogen dioxide
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0035715
name: chemokine (C-C motif) ligand 2 binding
namespace: molecular_function
def: "Binding to chemokine (C-C motif) ligand 2." [GOC:BHF]
synonym: "CCL2 binding" EXACT [GOC:ebc]
is_a: GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0035716
name: chemokine (C-C motif) ligand 12 binding
namespace: molecular_function
def: "Binding to chemokine (C-C motif) ligand 12." [GOC:BHF]
synonym: "CCL12 binding" EXACT [GOC:ebc]
is_a: GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0035717
name: chemokine (C-C motif) ligand 7 binding
namespace: molecular_function
def: "Binding to chemokine (C-C motif) ligand 7." [GOC:BHF]
synonym: "CCL7 binding" EXACT [GOC:ebc]
is_a: GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0035718
name: macrophage migration inhibitory factor binding
namespace: molecular_function
def: "Binding to the cytokine, macrophage migration inhibitory factor." [GOC:BHF, PMID:19601712]
synonym: "MIF binding" EXACT [PMID:19601712]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0035719
name: tRNA import into nucleus
namespace: biological_process
def: "The directed movement of tRNA from the cytoplasm to the nucleus." [GOC:vw, PMID:20032305]
synonym: "retrograde tRNA transport into nucleus" EXACT [GOC:vw, PMID:20032305]
synonym: "tRNA nuclear import" EXACT [GOC:vw]
is_a: GO:0006404 ! RNA import into nucleus
is_a: GO:0051031 ! tRNA transport

[Term]
id: GO:0035720
name: intraciliary anterograde transport
namespace: biological_process
def: "The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins." [GOC:BHF, GOC:cilia, PMID:17895364]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "intraflagellar anterograde transport" EXACT []
is_a: GO:0042073 ! intraciliary transport

[Term]
id: GO:0035721
name: intraciliary retrograde transport
namespace: biological_process
def: "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "intraflagellar retrograde transport" EXACT []
is_a: GO:0042073 ! intraciliary transport

[Term]
id: GO:0035722
name: interleukin-12-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-12-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-12-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071349 ! cellular response to interleukin-12

[Term]
id: GO:0035723
name: interleukin-15-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-15 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-15-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-15-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071350 ! cellular response to interleukin-15

[Term]
id: GO:0035724
name: CD24 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation." [GOC:BHF]
synonym: "CD24 anabolism" EXACT [GOC:bf]
synonym: "CD24 biosynthesis" EXACT [GOC:bf]
synonym: "CD24 formation" EXACT [GOC:bf]
synonym: "CD24 synthesis" EXACT [GOC:bf]
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0035725
name: sodium ion transmembrane transport
namespace: biological_process
def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "sodium ion membrane transport" EXACT []
is_a: GO:0006814 ! sodium ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0035726
name: common myeloid progenitor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage." [CL:0000049, GOC:BHF]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0035727
name: lysophosphatidic acid binding
namespace: molecular_function
def: "Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors." [GOC:curators]
synonym: "LPA binding" EXACT []
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0035728
name: response to hepatocyte growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf]
synonym: "response to hepatocyte growth factor stimulus" EXACT [GOC:dos]
synonym: "response to HGF stimulus" EXACT [GOC:bf]
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:0035729
name: cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf]
synonym: "cellular response to HGF stimulus" EXACT [GOC:bf]
is_a: GO:0035728 ! response to hepatocyte growth factor
is_a: GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0035730
name: S-nitrosoglutathione binding
namespace: molecular_function
def: "Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems." [GOC:BHF]
synonym: "GSNO binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0035731
name: dinitrosyl-iron complex binding
namespace: molecular_function
def: "Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO." [GOC:BHF, PMID:10534443]
synonym: "dinitrosyl-diglutathionyl-iron complex binding" EXACT [PMID:12871931]
synonym: "DNDGIC binding" EXACT [PMID:12871931]
synonym: "DNIC binding" EXACT [PMID:10534443]
is_a: GO:0051540 ! metal cluster binding

[Term]
id: GO:0035732
name: nitric oxide storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins." [GOC:BHF, PMID:12871945]
synonym: "NO storage" EXACT [GOC:bf]
is_a: GO:0051179 ! localization
relationship: part_of GO:0033484 ! intracellular nitric oxide homeostasis

[Term]
id: GO:0035733
name: hepatic stellate cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor." [CL:0000632, GOC:bf]
is_a: GO:0072537 ! fibroblast activation

[Term]
id: GO:0035735
name: intraciliary transport involved in cilium assembly
namespace: biological_process
def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia]
synonym: "intraciliary transport involved in cilium morphogenesis" RELATED []
synonym: "intraflagellar transport" BROAD []
synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED []
is_a: GO:0042073 ! intraciliary transport
relationship: part_of GO:0060271 ! cilium assembly

[Term]
id: GO:0035736
name: cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0035737
name: obsolete injection of substance in to other organism
namespace: biological_process
def: "OBSOLETE. The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes." [GOC:pamgo_curators]
comment: This term was obsoleted because it is specific to species that delivers venoms by biting; other organisms deliver venoms by other mechanisms, such as direct skin contact. Hence this terms describes a species rather than a specific process.
is_obsolete: true

[Term]
id: GO:0035738
name: envenomation resulting in modulation of process in another organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism." [GOC:pamgo_curators]
synonym: "envenomation resulting in modification of morphology or physiology of other organism" EXACT []
synonym: "envenomation resulting in modulation of process in other organism" EXACT []
is_a: GO:0035821 ! modulation of process of another organism

[Term]
id: GO:0035739
name: CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of a CD4-positive, alpha-beta T cell population by cell division." [CL:0000624, GOC:BHF]
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation
is_a: GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0035740
name: CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of a CD8-positive, alpha-beta T cell population by cell division." [CL:0000625, GOC:BHF]
is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation
is_a: GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0035741
name: activated CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of an activated CD4-positive, alpha-beta T cell population by cell division." [CL:0000896, GOC:BHF]
is_a: GO:0035739 ! CD4-positive, alpha-beta T cell proliferation

[Term]
id: GO:0035742
name: activated CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of an activated CD8-positive, alpha-beta T cell population by cell division." [CL:0000906, GOC:BHF]
is_a: GO:0035740 ! CD8-positive, alpha-beta T cell proliferation

[Term]
id: GO:0035743
name: CD4-positive, alpha-beta T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell." [CL:0000624, GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002369 ! T cell cytokine production

[Term]
id: GO:0035744
name: T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T-helper 1 cell." [CL:0000545, GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "Th1 cell cytokine production" EXACT [CL:0000545]
is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production
relationship: part_of GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0035745
name: T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T-helper 2 cell." [CL:0000546, GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "Th2 cell cytokine production" EXACT [CL:0000546]
is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production
relationship: part_of GO:0042092 ! type 2 immune response

[Term]
id: GO:0035746
name: granzyme A production
namespace: biological_process
def: "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0035747
name: natural killer cell chemotaxis
namespace: biological_process
def: "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000623, GOC:BHF]
is_a: GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0035748
name: myelin sheath abaxonal region
namespace: cellular_component
def: "The region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0035749
name: myelin sheath adaxonal region
namespace: cellular_component
def: "The region of the myelin sheath nearest to the axon." [GOC:BHF, PMID:20237282]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0035750
name: protein localization to myelin sheath abaxonal region
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282]
synonym: "protein localisation to myelin sheath abaxonal region" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0035751
name: regulation of lysosomal lumen pH
namespace: biological_process
def: "Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph]
is_a: GO:0051453 ! regulation of intracellular pH
relationship: part_of GO:0007040 ! lysosome organization

[Term]
id: GO:0035752
name: lysosomal lumen pH elevation
namespace: biological_process
def: "Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:bf, GOC:rph]
synonym: "lysosome pH elevation" EXACT [GOC:bf, GOC:rph]
is_a: GO:0035751 ! regulation of lysosomal lumen pH
is_a: GO:0051454 ! intracellular pH elevation

[Term]
id: GO:0035753
name: maintenance of DNA trinucleotide repeats
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs." [GOC:rb, PMID:21347277, SO:0000291]
is_a: GO:0043570 ! maintenance of DNA repeat elements

[Term]
id: GO:0035754
name: B cell chemotaxis
namespace: biological_process
def: "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000236, GOC:BHF]
is_a: GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0035755
name: cardiolipin hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA)." [GOC:sp, PMID:17028579, PMID:21397848]
xref: Reactome:R-HSA-8954398 "PLD6 dimer hydrolyses cardiolipin to PA and PG"
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0035756
name: symbiont-mediated migration across host transepithelium
namespace: biological_process
def: "A process in which a symbiont moves from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:10639460]
synonym: "migration in host through an epithelial cell layer" EXACT [GOC:bf]
synonym: "migration of symbiont within host by transepithelial trafficking" EXACT [GOC:bf]
synonym: "symbiont-mediated migration through host transepithelium" EXACT []
synonym: "transepithelial migration of symbiont in host" EXACT []
synonym: "transmigration of symbiont in host" RELATED []
is_a: GO:0141142 ! symbiont-mediated migration across host tissue barrier

[Term]
id: GO:0035757
name: chemokine (C-C motif) ligand 19 binding
namespace: molecular_function
def: "Binding to chemokine (C-C motif) ligand 19." [GOC:BHF]
synonym: "CCL19 binding" EXACT [GOC:bf]
is_a: GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0035758
name: chemokine (C-C motif) ligand 21 binding
namespace: molecular_function
def: "Binding to chemokine (C-C motif) ligand 21." [GOC:BHF]
synonym: "CCL21 binding" EXACT [GOC:bf]
is_a: GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0035759
name: mesangial cell-matrix adhesion
namespace: biological_process
def: "The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney." [CL:0000650, GOC:BHF, PMID:15569314]
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0035760
name: cytoplasmic polyadenylation-dependent rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate." [PMID:20368444]
synonym: "cytoplasmic poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0016075 ! rRNA catabolic process
is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process
is_a: GO:0180018 ! cytoplasmic polyadenylation-dependent RNA catabolic process

[Term]
id: GO:0035761
name: dorsal motor nucleus of vagus nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state." [GOC:dgh]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development

[Term]
id: GO:0035762
name: dorsal motor nucleus of vagus nerve morphogenesis
namespace: biological_process
def: "The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development

[Term]
id: GO:0035763
name: dorsal motor nucleus of vagus nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "dorsal motor nucleus of vagus nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis

[Term]
id: GO:0035764
name: dorsal motor nucleus of vagus nerve formation
namespace: biological_process
def: "The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis

[Term]
id: GO:0035765
name: motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation
namespace: biological_process
def: "The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve." [GOC:dgh, PMID:21262462]
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0035764 ! dorsal motor nucleus of vagus nerve formation

[Term]
id: GO:0035766
name: cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF)." [GOC:BHF]
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus

[Term]
id: GO:0035767
name: endothelial cell chemotaxis
namespace: biological_process
def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF]
is_a: GO:0043542 ! endothelial cell migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0035768
name: endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF)." [CL:0000115, GOC:BHF]
is_a: GO:0035766 ! cell chemotaxis to fibroblast growth factor
is_a: GO:0035767 ! endothelial cell chemotaxis

[Term]
id: GO:0035769
name: B cell chemotaxis across high endothelial venule
namespace: biological_process
def: "The movement of a B cell to cross a high endothelial venule in response to an external stimulus." [CL:0000236, GOC:BHF]
synonym: "B-cell chemotaxis across high endothelial venule" EXACT [GOC:ebc]
is_a: GO:0002518 ! lymphocyte chemotaxis across high endothelial venule
is_a: GO:0035754 ! B cell chemotaxis

[Term]
id: GO:0035770
name: ribonucleoprotein granule
namespace: cellular_component
def: "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]
synonym: "mRNP granule" EXACT []
synonym: "RNA granule" NARROW []
synonym: "RNP granule" EXACT []
is_a: GO:0043232 ! intracellular membraneless organelle
is_a: GO:0099080 ! supramolecular complex

[Term]
id: GO:0035771
name: interleukin-4-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-4 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-4-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-4-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071353 ! cellular response to interleukin-4

[Term]
id: GO:0035772
name: interleukin-13-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-13 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-13-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-13-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0035963 ! cellular response to interleukin-13

[Term]
id: GO:0035773
name: insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079]
synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf]
is_a: GO:0030073 ! insulin secretion
is_a: GO:0051649 ! establishment of localization in cell
relationship: part_of GO:0071333 ! cellular response to glucose stimulus

[Term]
id: GO:0035774
name: positive regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf]
synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf]
is_a: GO:0032024 ! positive regulation of insulin secretion
is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus
relationship: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus

[Term]
id: GO:0035775
name: pronephric glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus.
is_a: GO:0072102 ! glomerulus morphogenesis
relationship: part_of GO:0039021 ! pronephric glomerulus development

[Term]
id: GO:0035776
name: pronephric proximal tubule development
namespace: biological_process
def: "The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
is_a: GO:0039020 ! pronephric nephron tubule development
is_a: GO:0072014 ! proximal tubule development

[Term]
id: GO:0035777
name: pronephric distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
is_a: GO:0039020 ! pronephric nephron tubule development
is_a: GO:0072017 ! distal tubule development

[Term]
id: GO:0035778
name: pronephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
is_a: GO:0039014 ! cell differentiation involved in pronephros development
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: part_of GO:0039020 ! pronephric nephron tubule development

[Term]
id: GO:0035779
name: angioblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf]
synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566]
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0035780
name: CD80 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival." [GOC:BHF, GOC:ebc]
synonym: "CD80 anabolism" EXACT [GOC:bf]
synonym: "CD80 biosynthesis" EXACT [GOC:bf]
synonym: "CD80 formation" EXACT [GOC:bf]
synonym: "CD80 synthesis" EXACT [GOC:bf]
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0035781
name: CD86 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival." [GOC:BHF, GOC:ebc]
synonym: "CD86 anabolism" EXACT [GOC:bf]
synonym: "CD86 biosynthesis" EXACT [GOC:bf]
synonym: "CD86 formation" EXACT [GOC:bf]
synonym: "CD86 synthesis" EXACT [GOC:bf]
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0035782
name: mature natural killer cell chemotaxis
namespace: biological_process
def: "The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules." [CL:0000824, GOC:BHF]
synonym: "activated natural killer cell chemotaxis" EXACT [GOC:ebc]
is_a: GO:0035747 ! natural killer cell chemotaxis

[Term]
id: GO:0035783
name: CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation." [CL:0000624, GOC:BHF, GOC:pr]
synonym: "CD4-positive, alpha beta T cell costimulation" EXACT []
is_a: GO:0031295 ! T cell costimulation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation

[Term]
id: GO:0035784
name: obsolete nickel cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell." [GOC:kmv]
comment: The term is not clearly defined and usage has been inconsistent. For homeostasis terms, we would like to specify whether the homeostasis takes place intracellularly or at the level of the organism.
synonym: "nickel homeostasis" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0035785

[Term]
id: GO:0035785
name: intracellular nickel ion homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of nickel ions within a cell." [GOC:kmv]
synonym: "cellular nickel homeostasis" EXACT [GOC:bf]
synonym: "cellular nickel ion homeostasis" EXACT []
is_a: GO:0030003 ! intracellular monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0035787
name: cell migration involved in kidney development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0035788
name: cell migration involved in metanephros development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]
synonym: "cell migration involved in metanephric kidney development" EXACT [GOC:bf]
is_a: GO:0035787 ! cell migration involved in kidney development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0035789
name: metanephric mesenchymal cell migration
namespace: biological_process
def: "The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101, PMID:19019919]
synonym: "metanephric mesenchyme chemotaxis" NARROW [PMID:19019919]
is_a: GO:0035788 ! cell migration involved in metanephros development

[Term]
id: GO:0035790
name: platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961]
synonym: "alphaPDGF receptor signaling pathway" EXACT [PMID:10372961]
synonym: "PDGF receptor-alpha signaling pathway" EXACT [GOC:bf]
synonym: "PDGFR-alpha signaling pathway" RELATED [GOC:bf]
synonym: "platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0035791
name: platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961]
synonym: "betaPDGF receptor signaling pathway" EXACT [PMID:10372961]
synonym: "PDGF receptor-beta signaling pathway" EXACT [GOC:bf]
synonym: "PDGFR-beta signaling pathway" EXACT [GOC:bf]
synonym: "platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0035792
name: host cell postsynaptic membrane
namespace: cellular_component
def: "A postsynaptic membrane that is part of a host cell. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane." [GOC:ecd]
synonym: "other organism post-synaptic membrane" EXACT []
synonym: "other organism postsynaptic membrane" RELATED []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane

[Term]
id: GO:0035793
name: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration resulting from the platelet-derived growth factor receptor-beta signaling pathway." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101]
synonym: "positive regulation of metanephric mesenchymal cell migration by betaPDGF receptor signaling pathway" EXACT [PMID:10734101]
synonym: "positive regulation of metanephric mesenchymal cell migration by PDGF receptor-beta signaling pathway" EXACT [GOC:bf]
synonym: "positive regulation of metanephric mesenchymal cell migration by PDGFR-beta signaling pathway" EXACT [GOC:bf]
synonym: "positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:1900238 ! regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
is_a: GO:2000591 ! positive regulation of metanephric mesenchymal cell migration

[Term]
id: GO:0035794
name: positive regulation of mitochondrial membrane permeability
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810]
synonym: "mitochondrial membrane permeability transition" NARROW [PMID:17136322]
synonym: "mitochondrial membrane permeabilization" NARROW [PMID:12546810]
synonym: "mitochondrial permeability transition" NARROW [PMID:21424245]
synonym: "MPT" NARROW []
synonym: "positive regulation of transport across mitochondrial membrane" EXACT [GOC:bf]
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
is_a: GO:1905710 ! positive regulation of membrane permeability

[Term]
id: GO:0035795
name: negative regulation of mitochondrial membrane permeability
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [PMID:10781072]
synonym: "mitochondrial membrane impermeability" RELATED [PMID:10781072]
synonym: "mitochondrial membrane impermeabilization" NARROW [GOC:bf]
synonym: "negative regulation of transport across mitochondrial membrane" EXACT [GOC:bf]
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
is_a: GO:1905709 ! negative regulation of membrane permeability

[Term]
id: GO:0035796
name: ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing
namespace: cellular_component
def: "A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [PMID:18931129, PMID:20972419, PMID:21135102]
comment: The ECF-type transporters differs from other types of ABC transporters because the substrate-binding subunit lies integral to the membrane.
synonym: "ATP-binding cassette (ABC) transporter complex, ECF-type" EXACT [GOC:bf]
synonym: "energy coupling factor (ECF)-type ABC transporter" EXACT [PMID:21135102]
synonym: "energy-coupling factor transporter" EXACT [PMID:18931129]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0035797
name: tellurite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)." [GOC:bf, GOC:kad, PMID:11053398, PMID:21244361]
synonym: "S-adenosyl-L-methionine-dependent tellurite methyltransferase activity" EXACT [GOC:bf]
synonym: "SAM-dependent tellurite methyltransferase activity" EXACT [GOC:bf]
synonym: "tellurite methylase activity" BROAD [GOC:bf]
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0035798
name: 2-alkenal reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+." [PMID:16299173, RHEA:13737]
synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT [GOC:bf, GOC:kad]
xref: EC:1.3.1.102
xref: RHEA:13737
is_a: GO:0032440 ! 2-alkenal reductase [NAD(P)+] activity

[Term]
id: GO:0035799
name: ureter maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:17881463]
is_a: GO:0048799 ! animal organ maturation
relationship: part_of GO:0072189 ! ureter development

[Term]
id: GO:0035800
name: deubiquitinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a deubiquitinase." [GOC:sart, ISBN:0120793709]
is_a: GO:0016504 ! peptidase activator activity

[Term]
id: GO:0035801
name: adrenal cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens)." [PMID:12185666, PMID:21115154, Wikipedia:Adrenal_cortex]
synonym: "adrenal gland cortex development" EXACT [MA:0000118]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030325 ! adrenal gland development

[Term]
id: GO:0035802
name: adrenal cortex formation
namespace: biological_process
def: "The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate)." [PMID:12185666, PMID:21115154]
synonym: "adrenal gland cortex formation" EXACT [MA:0000118]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035801 ! adrenal cortex development

[Term]
id: GO:0035803
name: egg coat formation
namespace: biological_process
def: "Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [GOC:bf, GOC:sart, GOC:yaf, PMID:16944418, PMID:17163408]
synonym: "VE formation" NARROW [PMID:16944418, PMID:17163408]
synonym: "vitelline envelope formation" NARROW [PMID:16944418]
synonym: "zona pellucida assembly" NARROW [GOC:yaf, PMID:18420282]
synonym: "ZP assembly" NARROW [PMID:18420282]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0035804
name: structural constituent of egg coat
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408]
synonym: "structural constituent of vitelline envelope" NARROW [PMID:16944418, PMID:17163408]
synonym: "structural constituent of zona pellucida" NARROW [PMID:16944418, PMID:17163408]
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0035805
name: egg coat
namespace: cellular_component
def: "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408]
synonym: "vitelline membrane" NARROW [PMID:16944418, PMID:17163408]
synonym: "zona pellucida" NARROW [PMID:16944418, PMID:17163408]
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0035806
name: perturbation of blood coagulation in another organism
namespace: biological_process
def: "The process in which an organism effects a change that affects blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj]
synonym: "modulation by organism of blood clotting in other organism" EXACT [GOC:bf]
synonym: "modulation by organism of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "modulation of blood coagulation in another organism" EXACT []
synonym: "modulation of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "perturbation of blood clotting in another organism" EXACT []
synonym: "regulation by organism of blood clotting in other organism" EXACT [GOC:bf]
synonym: "regulation of blood clotting in other organism" EXACT [GOC:bf]
synonym: "regulation of blood coagulation in other organism" EXACT [GOC:bf]
is_a: GO:0035821 ! modulation of process of another organism

[Term]
id: GO:0035807
name: induction of blood coagulation in another organism
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj, PMID:12362232]
synonym: "induction of blood clotting in another organism" EXACT []
synonym: "positive regulation by organism of blood clotting in other organism" EXACT [GOC:bf]
synonym: "positive regulation by organism of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "positive regulation of blood clotting in other organism" EXACT [GOC:bf]
synonym: "positive regulation of blood coagulation in another organism" RELATED []
synonym: "positive regulation of blood coagulation in other organism" EXACT []
is_a: GO:0035806 ! perturbation of blood coagulation in another organism

[Term]
id: GO:0035808
name: meiotic recombination initiation complex
namespace: cellular_component
def: "A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins." [GOC:vw, PMID:12897161, PMID:20364342, PMID:21429938]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0035809
name: regulation of urine volume
namespace: biological_process
def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf]
synonym: "regulation of urinary volume" EXACT []
synonym: "regulation of urine flow" EXACT []
is_a: GO:0003014 ! renal system process
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0035810
name: positive regulation of urine volume
namespace: biological_process
def: "Any process that increases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf]
synonym: "diuresis" BROAD [GOC:mtg_25march11]
synonym: "elevation of urinary volume" EXACT [GOC:mtg_25march11]
synonym: "increase in urine flow" EXACT [GOC:mtg_25march11]
is_a: GO:0035809 ! regulation of urine volume

[Term]
id: GO:0035811
name: negative regulation of urine volume
namespace: biological_process
def: "Any process that decreases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf]
synonym: "antidiuresis" BROAD [GOC:mtg_25march11]
synonym: "decrease in urine flow" EXACT [GOC:mtg_25march11]
synonym: "reduction of urinary volume" EXACT [GOC:mtg_25march11]
is_a: GO:0035809 ! regulation of urine volume

[Term]
id: GO:0035812
name: renal sodium excretion
namespace: biological_process
def: "The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:mtg_25march11, GOC:yaf, PMID:25287933]
is_a: GO:0097254 ! renal tubular secretion
relationship: part_of GO:0055078 ! sodium ion homeostasis

[Term]
id: GO:0035813
name: regulation of renal sodium excretion
namespace: biological_process
def: "Any process that modulates the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0044062 ! regulation of excretion
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:0035812 ! renal sodium excretion

[Term]
id: GO:0035814
name: negative regulation of renal sodium excretion
namespace: biological_process
def: "Any process that decreases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
comment: The amount of sodium excreted in urine over a unit of time can be decreased by decreasing the volume of urine produced (antidiuresis) and/or by decreasing the concentration of sodium in the urine.
is_a: GO:0035813 ! regulation of renal sodium excretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0035812 ! renal sodium excretion

[Term]
id: GO:0035815
name: positive regulation of renal sodium excretion
namespace: biological_process
def: "Any process that increases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
comment: The amount of sodium excreted in urine over a unit of time can be increased by increasing the volume of urine produced (diuresis) and/or by increasing the concentration of sodium in the urine.
synonym: "natriuresis" BROAD [GOC:mtg_25march11]
is_a: GO:0035813 ! regulation of renal sodium excretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0035812 ! renal sodium excretion

[Term]
id: GO:0035816
name: obsolete renal water absorption involved in negative regulation of urine volume
namespace: biological_process
def: "OBSOLETE. Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time." [GOC:mtg_25march11, GOC:yaf]
comment: The reason for obsoletion is that there are no annotations and should be captured in GO-CAM and annotation extensions.
is_obsolete: true

[Term]
id: GO:0035817
name: renal sodium ion absorption involved in negative regulation of renal sodium excretion
namespace: biological_process
def: "Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0070294 ! renal sodium ion absorption
relationship: part_of GO:0035814 ! negative regulation of renal sodium excretion

[Term]
id: GO:0035818
name: positive regulation of urine volume by pressure natriuresis
namespace: biological_process
def: "An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf]
synonym: "diuresis resulting from pressure natriuresis" RELATED [GOC:mtg_25march11]
is_a: GO:0003095 ! pressure natriuresis
is_a: GO:0035810 ! positive regulation of urine volume

[Term]
id: GO:0035819
name: positive regulation of renal sodium excretion by pressure natriuresis
namespace: biological_process
def: "An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf]
synonym: "natriuresis resulting from pressure natriuresis" RELATED []
is_a: GO:0003095 ! pressure natriuresis
is_a: GO:0035815 ! positive regulation of renal sodium excretion

[Term]
id: GO:0035820
name: negative regulation of renal sodium excretion by angiotensin
namespace: biological_process
def: "The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0003083 ! negative regulation of renal output by angiotensin
is_a: GO:0035814 ! negative regulation of renal sodium excretion

[Term]
id: GO:0035821
name: modulation of process of another organism
namespace: biological_process
def: "The process in which an organism effects a change in the structure or processes of another organism." [GOC:bf]
synonym: "modification of morphology or physiology of other organism" EXACT []
synonym: "modulation of process of other organism" EXACT []
synonym: "regulation of morphology of other organism" NARROW [GOC:bf]
synonym: "regulation of morphology or physiology of other organism" RELATED [GOC:bf]
synonym: "regulation of physiological process of other organism" NARROW [GOC:bf]
synonym: "regulation of physiology of other organism" NARROW [GOC:bf]
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0035822
name: gene conversion
namespace: biological_process
def: "A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor. The resulting acceptor sequence is identical to that of the donor." [GOC:mah, PMID:17846636]
is_a: GO:0035825 ! homologous recombination

[Term]
id: GO:0035823
name: short tract gene conversion
namespace: biological_process
def: "A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385]
is_a: GO:0035822 ! gene conversion

[Term]
id: GO:0035824
name: long tract gene conversion
namespace: biological_process
def: "A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385]
is_a: GO:0035822 ! gene conversion

[Term]
id: GO:0035825
name: homologous recombination
namespace: biological_process
def: "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215]
synonym: "chromosomal crossover" RELATED [GOC:mah, Wikipedia:Chromosomal_crossover]
synonym: "interchromosomal DNA recombination" EXACT []
synonym: "interstrand DNA recombination" EXACT []
synonym: "reciprocal DNA recombination" NARROW []
xref: Wikipedia:Chromosomal_crossover
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0035826
name: obsolete rubidium ion transport
namespace: biological_process
def: "OBSOLETE. The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "Rb+ transport" EXACT []
synonym: "rubidium cation transport" EXACT []
is_obsolete: true

[Term]
id: GO:0035827
name: obsolete rubidium ion transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of rubidium ions (Rb+) from one side of a membrane to the other." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "Rb+ transmembrane transporter activity" EXACT []
synonym: "rubidium cation transmembrane transporter activity" EXACT []
synonym: "rubidium transmembrane transporter activity" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035828
name: obsolete renal rubidium ion transport
namespace: biological_process
def: "OBSOLETE. The directed movement of rubidium ions (Rb+) by the kidney." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "renal Rb+ transport" EXACT []
synonym: "renal rubidium cation transport" EXACT []
is_obsolete: true

[Term]
id: GO:0035829
name: obsolete renal rubidium ion absorption
namespace: biological_process
def: "OBSOLETE. A renal system process in which rubidium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "renal Rb+ absorption" EXACT []
synonym: "renal rubidium cation absorption" EXACT []
is_obsolete: true

[Term]
id: GO:0035830
name: palmatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants." [GOC:yaf, PMID:25285405]
synonym: "palmatine metabolism" EXACT [GOC:bf]
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0035831
name: palmatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants." [GOC:yaf, PMID:21327819]
synonym: "palmatine anabolism" EXACT [GOC:bf]
synonym: "palmatine biosynthesis" EXACT [GOC:bf]
synonym: "palmatine formation" EXACT [GOC:bf]
synonym: "palmatine synthesis" EXACT [GOC:bf]
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:0035830 ! palmatine metabolic process

[Term]
id: GO:0035832
name: berbamunine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid." [GOC:yaf]
synonym: "berbamunine metabolism" EXACT [GOC:bf]
is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0035833
name: berbamunine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid." [GOC:yaf]
synonym: "berbamunine anabolism" EXACT [GOC:bf]
synonym: "berbamunine biosynthesis" EXACT [GOC:bf]
synonym: "berbamunine formation" EXACT [GOC:bf]
synonym: "berbamunine synthesis" EXACT [GOC:bf]
is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process
is_a: GO:0035832 ! berbamunine metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0035834
name: indole alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf]
synonym: "indole alkaloid metabolism" EXACT [GOC:bf]
is_a: GO:0009820 ! alkaloid metabolic process

[Term]
id: GO:0035835
name: indole alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf]
synonym: "indole alkaloid anabolism" EXACT [GOC:bf]
synonym: "indole alkaloid biosynthesis" EXACT [GOC:bf]
synonym: "indole alkaloid formation" EXACT [GOC:bf]
synonym: "indole alkaloid synthesis" EXACT [GOC:bf]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0035834 ! indole alkaloid metabolic process

[Term]
id: GO:0035836
name: ergot alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid." [GOC:yaf]
synonym: "ergot alkaloid metabolism" EXACT [GOC:bf]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process

[Term]
id: GO:0035837
name: ergot alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an ergot alkaloid." [GOC:yaf]
synonym: "ergot alkaloid anabolism" EXACT [GOC:bf]
synonym: "ergot alkaloid biosynthesis" EXACT [GOC:bf]
synonym: "ergot alkaloid formation" EXACT [GOC:bf]
synonym: "ergot alkaloid synthesis" EXACT [GOC:bf]
is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process
is_a: GO:0035836 ! ergot alkaloid metabolic process

[Term]
id: GO:0035838
name: growing cell tip
namespace: cellular_component
def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs." [GOC:mah]
synonym: "growing cell end" EXACT [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0051286 ! cell tip

[Term]
id: GO:0035839
name: non-growing cell tip
namespace: cellular_component
def: "A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures." [GOC:expert_jd, GOC:mah]
synonym: "new cell end" RELATED [GOC:mah]
synonym: "non-growing cell end" EXACT [GOC:mah]
is_a: GO:0051286 ! cell tip

[Term]
id: GO:0035840
name: old growing cell tip
namespace: cellular_component
def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah]
synonym: "old growing cell end" EXACT [GOC:mah]
is_a: GO:0035838 ! growing cell tip

[Term]
id: GO:0035841
name: new growing cell tip
namespace: cellular_component
def: "A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth." [GOC:expert_jd, GOC:mah, PMID:19431238]
synonym: "new cell tip after activation of bipolar cell growth" EXACT [GOC:bf]
synonym: "post-NETO new cell end" EXACT [GOC:mah]
synonym: "post-NETO new cell tip" EXACT [GOC:mah]
synonym: "post-new end take-off new cell tip" EXACT [GOC:mah]
is_a: GO:0035838 ! growing cell tip

[Term]
id: GO:0035842
name: old cell tip after activation of bipolar cell growth
namespace: cellular_component
def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah]
synonym: "post-NETO old cell end" EXACT [GOC:mah]
synonym: "post-NETO old cell tip" EXACT [GOC:mah]
synonym: "post-new end take-off old cell tip" EXACT [GOC:mah]
is_a: GO:0035840 ! old growing cell tip

[Term]
id: GO:0035843
name: endonuclear canal
namespace: cellular_component
def: "A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope." [GOC:bf, PMID:18359585]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0001673 ! male germ cell nucleus

[Term]
id: GO:0035844
name: cloaca development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089]
synonym: "cloacal development" EXACT [GOC:bf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001655 ! urogenital system development
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0035845
name: photoreceptor cell outer segment organization
namespace: biological_process
def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials." [ISBN:0824072820, PMID:14507858]
synonym: "photoreceptor cell outer segment organisation" EXACT [GOC:mah]
synonym: "photoreceptor outer segment organization" EXACT [GOC:bf]
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0042461 ! photoreceptor cell development

[Term]
id: GO:0035846
name: oviduct epithelium development
namespace: biological_process
def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, PMID:34496237]
synonym: "fallopian tube epithelium development" NARROW [GOC:yaf]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0060066 ! oviduct development

[Term]
id: GO:0035847
name: uterine epithelium development
namespace: biological_process
def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf]
synonym: "uterus epithelial development" EXACT [GOC:yaf]
is_a: GO:0035846 ! oviduct epithelium development
relationship: part_of GO:0060065 ! uterus development

[Term]
id: GO:0035848
name: oviduct morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, PMID:22918811]
synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0060066 ! oviduct development

[Term]
id: GO:0035849
name: nephric duct elongation
namespace: biological_process
def: "The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0072178 ! nephric duct morphogenesis

[Term]
id: GO:0035850
name: epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development

[Term]
id: GO:0035851
name: Krueppel-associated box domain binding
namespace: molecular_function
def: "Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors." [InterPro:IPR001909]
synonym: "KRAB domain binding" EXACT [InterPro:IPR001909]
synonym: "Krueppel-associated box binding" EXACT [InterPro:IPR001909]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0035852
name: horizontal cell localization
namespace: biological_process
def: "Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina." [CL:0000745, GOC:bf, GOC:yaf, PMID:18094249]
synonym: "horizontal cell localisation" EXACT [GOC:mah]
synonym: "horizontal cell positioning" EXACT [PMID:18094249]
synonym: "laminar positioning of retinal horizontal cell" EXACT [PMID:18094249]
synonym: "retinal horizontal cell positioning" EXACT [PMID:18094249]
is_a: GO:0051674 ! localization of cell
relationship: part_of GO:0010842 ! retina layer formation

[Term]
id: GO:0035853
name: chromosome passenger complex localization to spindle midzone
namespace: biological_process
def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:mah, GOC:vw, PMID:15296749]
synonym: "chromosomal passenger complex localization to spindle midzone" EXACT [GOC:bf]
synonym: "chromosome passenger complex localisation to spindle midzone" EXACT [GOC:bf]
synonym: "chromosome passenger complex localization to central spindle" EXACT [PMID:14528012]
synonym: "chromosome passenger complex localization to spindle equator" EXACT [GOC:bf]
synonym: "CPC complex localization to spindle midzone" EXACT [GOC:bf]
synonym: "CPC localization to spindle midzone" EXACT [GOC:bf]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0044380 ! protein localization to cytoskeleton

[Term]
id: GO:0035854
name: eosinophil fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [CL:0000771, GOC:BHF, GOC:vk]
synonym: "eosinophil cell fate commitment" EXACT [GOC:bf]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0035855
name: megakaryocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk]
synonym: "megakaryocyte cell development" EXACT [GOC:bf]
is_a: GO:0061515 ! myeloid cell development
relationship: part_of GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0035857
name: eosinophil fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [CL:0000771, GOC:BHF, GOC:vk]
synonym: "eosinophil cell fate specification" EXACT [GOC:bf]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0035854 ! eosinophil fate commitment

[Term]
id: GO:0035858
name: eosinophil fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000771, GOC:BHF, GOC:vk]
synonym: "eosinophil cell fate determination" EXACT [GOC:bf]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0035854 ! eosinophil fate commitment

[Term]
id: GO:0035859
name: Seh1-associated complex
namespace: cellular_component
def: "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112]
comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
synonym: "GATOR complex" EXACT [GOC:rb, PMID:23723238]
synonym: "SEA complex" EXACT [GOC:jh, PMID:21454883]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0035860
name: glial cell-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a glial cell-derived neurotrophic factor receptor." [GOC:yaf, PMID:12953054, PMID:29245123]
synonym: "GDNF receptor signaling pathway" EXACT [GOC:yaf]
synonym: "glial cell derived neurotrophic factor receptor signaling pathway" EXACT [GOC:bf]
synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:yaf]
synonym: "glial cell-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0035861
name: site of double-strand break
namespace: cellular_component
def: "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]
synonym: "DNA damage foci" RELATED [GOC:vw]
synonym: "DNA damage focus" RELATED [GOC:mah, PMID:20096808, PMID:21035408]
synonym: "ionizing radiation-induced foci" RELATED [PMID:20096808, PMID:21035408]
synonym: "IRIF" RELATED [PMID:20096808, PMID:21035408]
synonym: "site of DSB" EXACT [PMID:21035408]
is_a: GO:0090734 ! site of DNA damage

[Term]
id: GO:0035862
name: dITP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [GOC:bf]
synonym: "2'-Deoxyinosine 5'-triphosphate metabolic process" EXACT []
synonym: "2'-Deoxyinosine-5'-triphosphate metabolic process" EXACT []
synonym: "deoxyinosine 5'-triphosphate metabolic process" EXACT []
synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process" EXACT [GOC:dgf]
synonym: "dITP metabolism" EXACT [GOC:bf]
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0035863
name: dITP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [GOC:dgf]
synonym: "2'-Deoxyinosine 5'-triphosphate catabolic process" EXACT []
synonym: "2'-Deoxyinosine-5'-triphosphate catabolic process" EXACT []
synonym: "deoxyinosine 5'-triphosphate catabolic process" EXACT []
synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) catabolic process" EXACT [GOC:dgf]
synonym: "dITP breakdown" EXACT [GOC:bf]
synonym: "dITP catabolism" EXACT [GOC:bf]
synonym: "dITP degradation" EXACT [GOC:bf]
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0035862 ! dITP metabolic process

[Term]
id: GO:0035864
name: response to potassium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf]
synonym: "response to K+ ion" EXACT [GOC:bf]
synonym: "response to potassium" EXACT [GOC:bf]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0035865
name: cellular response to potassium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf]
synonym: "cellular response to K+ ion" EXACT [GOC:bf]
synonym: "cellular response to potassium" EXACT [GOC:bf]
is_a: GO:0035864 ! response to potassium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0035866
name: alphav-beta3 integrin-PKCalpha complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha." [GOC:BHF, GOC:ebc, PMID:16014375]
synonym: "alphav-beta3 integrin-PKCa complex" EXACT [GOC:ebc]
synonym: "alphav-beta3 integrin-protein kinase C alpha complex" EXACT [GOC:bf]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0035867
name: alphav-beta3 integrin-IGF-1-IGF1R complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits." [GOC:BHF, GOC:ebc, PMID:19578119]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0035868
name: alphav-beta3 integrin-HMGB1 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein." [GOC:BHF, GOC:ebc, PMID:20826760]
synonym: "alphav-beta3 integrin-high mobility group box 1 complex" EXACT [GOC:bf]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0035869
name: ciliary transition zone
namespace: cellular_component
def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]
comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone.
synonym: "cilial transition zone" EXACT []
synonym: "cilium transition zone" EXACT []
synonym: "connecting cilium" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0035870
name: dITP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate." [GOC:dgf, PMID:21548881, RHEA:28342]
synonym: "2'-deoxyinosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R03531]
synonym: "deoxyinosine triphosphate pyrophosphatase activity" EXACT [GOC:bf]
synonym: "dITP pyrophosphatase activity" EXACT [GOC:bf]
xref: KEGG_REACTION:R03531
xref: MetaCyc:RXN0-1602
xref: Reactome:R-HSA-2509838 "ITPA hydrolyses dITP to dIMP"
xref: RHEA:28342
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0035871
name: protein K11-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein." [GOC:sp, PMID:21596315]
synonym: "protein K11-linked deubiquitinylation" EXACT [GOC:bf]
synonym: "protein K11-linked deubiquitylation" EXACT [GOC:bf]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0035872
name: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number." [GOC:sj, PMID:18280719, PMID:32838963, PMID:36973360]
synonym: "NLR signaling pathway" EXACT [PMID:18280719]
synonym: "NOD-like receptor signaling pathway" RELATED [Wikipedia:NOD-like_receptor]
synonym: "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway" EXACT [PMID:18280719]
synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction" EXACT [GOC:bf]
synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway" EXACT [GOC:bf]
synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0035873
name: lactate transmembrane transport
namespace: biological_process
def: "The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:mcc, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "lactate membrane transport" EXACT []
is_a: GO:0015727 ! lactate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0035874
name: cellular response to copper ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions." [GOC:vw, PMID:16467469]
synonym: "cellular response to copper starvation" EXACT [GOC:bf]
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0120126 ! response to copper ion starvation

[Term]
id: GO:0035875
name: maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436]
synonym: "maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf]
synonym: "maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:bf]
synonym: "maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:bf]
is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion
relationship: part_of GO:0051754 ! meiotic sister chromatid cohesion, centromeric

[Term]
id: GO:0035876
name: obsolete maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "OBSOLETE. The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436]
comment: This term was added in error
synonym: "maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:bf]
synonym: "maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035877
name: death effector domain binding
namespace: molecular_function
def: "Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)." [GOC:ecd, InterPro:IPR001875]
comment: For binding to the death domain, consider instead the term 'death domain binding ; GO:0070513'.
synonym: "DED binding" EXACT [InterPro:IPR001875]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0035878
name: nail development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060173 ! limb development

[Term]
id: GO:0035879
name: plasma membrane lactate transport
namespace: biological_process
def: "The directed movement of lactate across a plasma membrane." [GOC:mcc]
synonym: "lactate plasma membrane transport" EXACT [GOC:bf]
is_a: GO:0035873 ! lactate transmembrane transport

[Term]
id: GO:0035880
name: embryonic nail plate morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits." [GOC:BHF, GOC:vk, ISBN:0323025781, PMID:11369996, UBERON:0008198, Wikipedia:Nail_(anatomy)]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0035878 ! nail development
relationship: part_of GO:0042733 ! embryonic digit morphogenesis

[Term]
id: GO:0035881
name: amacrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons." [CL:0000561, GOC:bf]
synonym: "amacrine neuron differentiation" EXACT [CL:0000561]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0003407 ! neural retina development

[Term]
id: GO:0035882
name: defecation rhythm
namespace: biological_process
def: "The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated." [GOC:bf, GOC:kmv, PMID:7479775, PMID:8158250, PMID:9066270]
synonym: "defecation behavior" RELATED [PMID:7479775, PMID:9066270]
synonym: "defecation cycle" EXACT [PMID:8158250]
synonym: "defecation motor program" EXACT [GOC:kmv, PMID:9066270]
synonym: "DMP" EXACT [PMID:9066270]
is_a: GO:0007624 ! ultradian rhythm
relationship: part_of GO:0030421 ! defecation

[Term]
id: GO:0035883
name: enteroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf]
is_a: GO:0002067 ! glandular epithelial cell differentiation

[Term]
id: GO:0035884
name: arabinan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues." [GOC:rs, ISBN:0198506732]
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0031221 ! arabinan metabolic process

[Term]
id: GO:0035885
name: exochitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain." [GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509]
xref: MetaCyc:RXN-12309
xref: RHEA:50672
is_a: GO:0004568 ! chitinase activity

[Term]
id: GO:0035886
name: vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954]
synonym: "vascular smooth muscle cell differentiation" EXACT []
synonym: "VSMC differentiation" EXACT [PMID:16151017]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0035887
name: aortic smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl]
is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation

[Term]
id: GO:0035888
name: isoguanine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine." [PMID:21604715, RHEA:47720]
synonym: "2-hydroxyadenine deaminase activity" EXACT [PMID:14709079, PMID:8841637]
synonym: "2-oxoadenine deaminase activity" EXACT [PMID:14709079]
xref: MetaCyc:RXN0-6708
xref: RHEA:47720
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0035889
name: otolith tethering
namespace: biological_process
def: "The attachment of a developing otolith to the kinocilia of tether cells in the inner ear." [GOC:dgh, PMID:14499652]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0048840 ! otolith development

[Term]
id: GO:0035891
name: exit from host cell
namespace: biological_process
alt_id: GO:0035890
def: "The movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:rs, PMID:19325115]
subset: goslim_virus
synonym: "ejection from host" RELATED [GOC:bf]
synonym: "ejection from host cell" RELATED [PMID:19325115]
synonym: "exit from host" RELATED []
synonym: "host cell exit" EXACT [PMID:19325115]
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0035892
name: perturbation of platelet aggregation in another organism
namespace: biological_process
def: "The process in which an organism effects a change that affects platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:bf, GOC:fj, PMID:15922770]
synonym: "modulation by organism of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "modulation of platelet aggregation in another organism" EXACT []
synonym: "modulation of platelet aggregation in other organism" EXACT []
synonym: "regulation of platelet aggregation in other organism" RELATED [GOC:bf]
is_a: GO:0035806 ! perturbation of blood coagulation in another organism
is_a: GO:0090330 ! regulation of platelet aggregation

[Term]
id: GO:0035893
name: suppression of platelet aggregation in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism." [GOC:bf, GOC:fj, PMID:15922770]
synonym: "disruption of platelet aggregation in other organism" EXACT []
synonym: "down-regulation of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "downregulation of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "inhibition of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "negative regulation of platelet aggregation in another organism" RELATED []
synonym: "negative regulation of platelet aggregation in other organism" EXACT []
is_a: GO:0035892 ! perturbation of platelet aggregation in another organism
is_a: GO:0035899 ! suppression of blood coagulation in another organism

[Term]
id: GO:0035894
name: induction of platelet aggregation in another organism
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism." [GOC:bf, GOC:fj, PMID:11453648, PMID:18804547]
synonym: "positive regulation of platelet aggregation in another organism" RELATED []
synonym: "positive regulation of platelet aggregation in other organism" EXACT []
synonym: "up-regulation of platelet aggregation in other organism" RELATED [GOC:bf]
synonym: "upregulation of platelet aggregation in other organism" EXACT [GOC:bf]
is_a: GO:0035807 ! induction of blood coagulation in another organism
is_a: GO:0035892 ! perturbation of platelet aggregation in another organism

[Term]
id: GO:0035895
name: modulation of mast cell degranulation in another organism
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [GOC:bf, GOC:fj, PMID:21549739]
synonym: "modulation of mast cell degranulation in other organism" EXACT []
synonym: "regulation of mast cell degranulation in other organism" EXACT [GOC:bf]
is_a: GO:0035821 ! modulation of process of another organism
is_a: GO:0043304 ! regulation of mast cell degranulation

[Term]
id: GO:0035896
name: positive regulation of mast cell degranulation in another organism
namespace: biological_process
def: "Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism." [GOC:bf, GOC:fj]
synonym: "positive regulation of mast cell degranulation in other organism" EXACT []
synonym: "up-regulation of mast cell degranulation in other organism" RELATED [GOC:bf]
synonym: "upregulation of mast cell degranulation in other organism" EXACT [GOC:bf]
is_a: GO:0035895 ! modulation of mast cell degranulation in another organism
is_a: GO:0043306 ! positive regulation of mast cell degranulation

[Term]
id: GO:0035897
name: obsolete proteolysis in other organism
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the hydrolysis of proteins in another organism by cleavage of their peptide bonds." [GOC:bf, GOC:fj, PMID:15922779]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0035898
name: parathyroid hormone secretion
namespace: biological_process
def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021]
synonym: "parathormone secretion" EXACT [PR:000013429]
synonym: "parathyrin secretion" EXACT [PR:000013429]
synonym: "PTH secretion" EXACT [PMID:12171519, PR:000013429]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0035899
name: suppression of blood coagulation in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:fj, PMID:30563903]
synonym: "disruption of blood coagulation in other organism" EXACT []
synonym: "down-regulation of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "downregulation of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "inhibition of blood coagulation in other organism" NARROW [GOC:bf]
synonym: "negative regulation of blood clotting in other organism" EXACT [GOC:bf]
synonym: "negative regulation of blood coagulation in another organism" RELATED []
synonym: "negative regulation of blood coagulation in other organism" EXACT []
synonym: "suppression of blood clotting in another organism" EXACT []
is_a: GO:0035806 ! perturbation of blood coagulation in another organism

[Term]
id: GO:0035900
name: response to isolation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532]
synonym: "response to social isolation" EXACT [PMID:20203532]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0035901
name: cellular response to isolation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532]
synonym: "cellular response to social isolation" EXACT [PMID:20203532]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035900 ! response to isolation stress

[Term]
id: GO:0035902
name: response to immobilization stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991]
synonym: "response to immobilisation stress" EXACT [GOC:bf]
synonym: "response to restraint stress" RELATED [GOC:sl]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0035903
name: cellular response to immobilization stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991]
synonym: "cellular response to immobilisation stress" EXACT [GOC:bf]
synonym: "cellular response to restraint stress" RELATED [GOC:sl]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035902 ! response to immobilization stress

[Term]
id: GO:0035904
name: aorta development
namespace: biological_process
def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0060840 ! artery development

[Term]
id: GO:0035905
name: ascending aorta development
namespace: biological_process
def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035904 ! aorta development

[Term]
id: GO:0035906
name: descending aorta development
namespace: biological_process
def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035904 ! aorta development

[Term]
id: GO:0035907
name: dorsal aorta development
namespace: biological_process
def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035904 ! aorta development

[Term]
id: GO:0035908
name: ventral aorta development
namespace: biological_process
def: "The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]
is_a: GO:0035904 ! aorta development

[Term]
id: GO:0035909
name: aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0048844 ! artery morphogenesis
relationship: part_of GO:0035904 ! aorta development

[Term]
id: GO:0035910
name: ascending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0035905 ! ascending aorta development
relationship: part_of GO:0035909 ! aorta morphogenesis

[Term]
id: GO:0035911
name: descending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0035906 ! descending aorta development
relationship: part_of GO:0035909 ! aorta morphogenesis

[Term]
id: GO:0035912
name: dorsal aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035909 ! aorta morphogenesis
relationship: part_of GO:0035907 ! dorsal aorta development

[Term]
id: GO:0035913
name: ventral aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]
is_a: GO:0035909 ! aorta morphogenesis
relationship: part_of GO:0035908 ! ventral aorta development

[Term]
id: GO:0035914
name: skeletal muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0035915
name: pore formation in membrane of another organism
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism." [GOC:bf, GOC:fj, PMID:21549739]
synonym: "pore complex assembly in other organism" EXACT []
synonym: "pore complex biogenesis in other organism" EXACT [GOC:bf]
synonym: "pore formation in membrane of other organism" EXACT []
synonym: "pore formation in other organism" EXACT [GOC:bf]
synonym: "pore-forming toxin activity" RELATED [GOC:bf]
is_a: GO:0051673 ! disruption of plasma membrane integrity in another organism

[Term]
id: GO:0035916
name: modulation of calcium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515]
synonym: "modulation of calcium channel activity in other organism" EXACT []
is_a: GO:0044561 ! modulation of ion channel activity in another organism

[Term]
id: GO:0035917
name: negative regulation of calcium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515]
synonym: "down-regulation of calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of calcium channel activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of calcium channel activity in other organism" EXACT [GOC:bf]
is_a: GO:0035916 ! modulation of calcium channel activity in another organism

[Term]
id: GO:0035918
name: negative regulation of voltage-gated calcium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]
synonym: "down-regulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of voltage-gated calcium channel activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of voltage gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of voltage-gated calcium channel activity in other organism" EXACT []
synonym: "negative regulation of voltage-sensitive calcium channel activity in other organism" EXACT [GOC:bf]
is_a: GO:0035917 ! negative regulation of calcium channel activity in another organism

[Term]
id: GO:0035919
name: negative regulation of low voltage-gated calcium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]
synonym: "down-regulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of low voltage-gated calcium channel activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of low voltage gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of low voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of low voltage-gated calcium channel activity in other organism" EXACT []
is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in another organism

[Term]
id: GO:0035920
name: negative regulation of high voltage-gated calcium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]
synonym: "down-regulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of high voltage-gated calcium channel activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of high voltage gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of high voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in another organism

[Term]
id: GO:0035921
name: desmosome disassembly
namespace: biological_process
def: "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671]
synonym: "desmosome dissociation" EXACT [PMID:9182671]
is_a: GO:0002934 ! desmosome organization
is_a: GO:0150147 ! cell-cell junction disassembly

[Term]
id: GO:0035922
name: foramen ovale closure
namespace: biological_process
def: "The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow." [GOC:BHF, GOC:vk, PMID:19762328, UBERON:0004754, Wikipedia:Foramen_ovale_(heart)]
synonym: "foramen ovale of heart closure" EXACT [UBERON:0004754]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060411 ! cardiac septum morphogenesis

[Term]
id: GO:0035923
name: flurbiprofen binding
namespace: molecular_function
def: "Binding to flurbiprofen." [GOC:BHF, GOC:rl]
synonym: "2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding" EXACT []
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0035924
name: cellular response to vascular endothelial growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, PMID:18440775]
synonym: "cellular response to vascular endothelial growth factor" EXACT [GOC:rl]
synonym: "cellular response to VEGF" EXACT [GOC:rl]
synonym: "cellular response to VEGFA" NARROW [GOC:rl]
synonym: "cellular response to VEGFB" NARROW [GOC:rl]
is_a: GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0035925
name: mRNA 3'-UTR AU-rich region binding
namespace: molecular_function
alt_id: GO:0017091
def: "Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]
synonym: "adenylate/uridylate-rich element binding" EXACT []
synonym: "ARE binding" RELATED []
synonym: "AU-rich element binding" RELATED []
synonym: "mRNA 3'-UTR adenylate/uridylate-rich element binding" EXACT [PMID:8578590]
is_a: GO:0003730 ! mRNA 3'-UTR binding

[Term]
id: GO:0035927
name: RNA import into mitochondrion
namespace: biological_process
def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix." [GOC:ans, PMID:20691904]
synonym: "cytoplasmic RNA import into mitochondrion" NARROW [GOC:ans]
synonym: "nuclear-encoded RNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0050658 ! RNA transport
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:0035928
name: rRNA import into mitochondrion
namespace: biological_process
def: "The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix." [GOC:ans, PMID:20691904]
synonym: "cytoplasmic rRNA import into mitochondrion" NARROW [GOC:ans]
synonym: "nuclear-encoded rRNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0035927 ! RNA import into mitochondrion
is_a: GO:0051029 ! rRNA transport

[Term]
id: GO:0035929
name: steroid hormone secretion
namespace: biological_process
def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl]
is_a: GO:0060986 ! endocrine hormone secretion
is_a: GO:0140353 ! lipid export from cell

[Term]
id: GO:0035930
name: corticosteroid hormone secretion
namespace: biological_process
def: "The regulated release of any corticosteroid hormone into the circulatory system." [GOC:sl]
synonym: "corticosteroid secretion" BROAD [GOC:bf]
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035931
name: mineralocorticoid secretion
namespace: biological_process
def: "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." [GOC:sl]
is_a: GO:0035930 ! corticosteroid hormone secretion

[Term]
id: GO:0035932
name: aldosterone secretion
namespace: biological_process
def: "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." [GOC:sl]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035931 ! mineralocorticoid secretion

[Term]
id: GO:0035933
name: glucocorticoid secretion
namespace: biological_process
def: "The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood." [GOC:sl]
is_a: GO:0035930 ! corticosteroid hormone secretion

[Term]
id: GO:0035934
name: corticosterone secretion
namespace: biological_process
def: "The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands." [GOC:sl]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035933 ! glucocorticoid secretion

[Term]
id: GO:0035935
name: androgen secretion
namespace: biological_process
def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl]
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035936
name: testosterone secretion
namespace: biological_process
def: "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." [GOC:sl, PMID:12606499]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0046879 ! hormone secretion
is_a: GO:0140353 ! lipid export from cell

[Term]
id: GO:0035937
name: estrogen secretion
namespace: biological_process
def: "The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals." [GOC:sl]
synonym: "oestrogen secretion" RELATED []
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035938
name: estradiol secretion
namespace: biological_process
def: "The regulated release of estradiol into the circulatory system." [GOC:sl, PMID:21632818]
synonym: "oestradiol secretion" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035939
name: microsatellite binding
namespace: molecular_function
def: "Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem." [GOC:yaf, PMID:21290414, SO:0000289]
synonym: "microsatellite DNA binding" EXACT [GOC:bf]
synonym: "variable number tandem repeat binding" EXACT [PMID:21290414]
synonym: "VNTR binding" EXACT [SO:0000289]
is_a: GO:0003696 ! satellite DNA binding

[Term]
id: GO:0035940
name: obsolete negative regulation of peptidase activity in other organism
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism." [GOC:klp, PMID:10595640]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of peptidase activity in other organism" EXACT [GOC:bf]
synonym: "down-regulation of protease activity in other organism" NARROW [GOC:bf]
synonym: "downregulation of peptidase activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of protease activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of protease activity in other organism" NARROW [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035941
name: androstenedione secretion
namespace: biological_process
def: "The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system." [GOC:sl]
synonym: "androst-4-ene-3,17-dione secretion" EXACT []
is_a: GO:0046879 ! hormone secretion
is_a: GO:0140353 ! lipid export from cell

[Term]
id: GO:0035942
name: dehydroepiandrosterone secretion
namespace: biological_process
def: "The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system." [GOC:sl]
synonym: "3beta-hydroxyandrost-5-en-17-one secretion" EXACT []
synonym: "dehydroisoandrosterone secretion" EXACT []
synonym: "DHEA secretion" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0046879 ! hormone secretion
is_a: GO:0140353 ! lipid export from cell

[Term]
id: GO:0035943
name: estrone secretion
namespace: biological_process
def: "The regulated release of estrone into the circulatory system." [GOC:sl, PMID:8395854]
synonym: "3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT []
synonym: "folliculin secretion" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0035944
name: perforin production
namespace: biological_process
def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0035945
name: mitochondrial ncRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion." [GOC:ans, PMID:19864255]
synonym: "mitochondrial aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "mitochondrial ncRNA quality control" EXACT [GOC:dgf, GOC:krc]
synonym: "mitochondrial non-coding RNA surveillance" EXACT [GOC:bf]
is_a: GO:2000827 ! mitochondrial RNA surveillance

[Term]
id: GO:0035946
name: mitochondrial mRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion." [GOC:ans, PMID:19864255]
synonym: "mitochondrial aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "mitochondrial messenger RNA surveillance" EXACT [GOC:bf]
synonym: "mitochondrial mRNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0000958 ! mitochondrial mRNA catabolic process
is_a: GO:2000827 ! mitochondrial RNA surveillance

[Term]
id: GO:0035947
name: obsolete regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of gluconeogenesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035948
name: obsolete positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of gluconeogenesis by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of glucose biosynthetic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035949
name: obsolete positive regulation of gluconeogenesis by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gluconeogenesis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of gluconeogenesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of gluconeogenesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of gluconeogenesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of gluconeogenesis by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol]
synonym: "positive regulation of gluconeogenesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035950
name: obsolete regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of oligopeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of oligopeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035951
name: obsolete positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of oligopeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of oligopeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035952
name: obsolete negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of oligopeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of oligopeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of oligopeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of oligopeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol]
synonym: "negative regulation of oligopeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035953
name: obsolete regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of dipeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of dipeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035954
name: obsolete positive regulation of dipeptide transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of dipeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of dipeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035955
name: obsolete negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:10850718, PMID:17005992, PMID:9427760]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of dipeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of dipeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of dipeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of dipeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol]
synonym: "negative regulation of dipeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035956
name: obsolete regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the breakdown of starch, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9342405]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GGOC:obol]
synonym: "regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035957
name: obsolete positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the breakdown of starch, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035958
name: obsolete regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the glyoxylate cycle by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of glyoxylate bypass by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glyoxylate bypass by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glyoxylate cycle by regulation of transcription from Pol II promoter" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035959
name: obsolete positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the glyoxylate cycle by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035960
name: obsolete regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ergosterol biosynthetic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229, PMID:16055745]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of ergosterol anabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol anabolism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol biosynthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol biosynthetic process by regulation of transcription from Pol II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol formation by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol formation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol synthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol synthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035961
name: obsolete positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ergosterol biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by activation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by positive regulation of transcription from Pol II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by stimulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by up regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by upregulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol formation by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol formation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol formation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol formation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol formation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035962
name: response to interleukin-13
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461]
synonym: "response to IL-13" EXACT [GOC:bf]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0035963
name: cellular response to interleukin-13
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461]
synonym: "cellular response to IL-13" EXACT [GOC:bf]
is_a: GO:0035962 ! response to interleukin-13
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0035964
name: COPI-coated vesicle budding
namespace: biological_process
def: "The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle." [GOC:br, PMID:10052452, PMID:17041781]
synonym: "COPI vesicle budding" EXACT [PMID:17041781]
is_a: GO:0006900 ! vesicle budding from membrane
relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0035965
name: cardiolipin acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids." [GOC:bf, GOC:rb, PMID:19244244]
synonym: "cardiolipin acyl-chain remodelling" EXACT [GOC:bf]
synonym: "cardiolipin maturation" BROAD [GOC:rb]
synonym: "diphosphatidylglycerol remodeling" RELATED []
is_a: GO:0032048 ! cardiolipin metabolic process

[Term]
id: GO:0035966
name: response to topologically incorrect protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]
synonym: "response to misfolded or unfolded protein" RELATED [GOC:bf]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0035967
name: cellular response to topologically incorrect protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]
synonym: "cellular response to misfolded or unfolded protein" RELATED [GOC:bf]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035966 ! response to topologically incorrect protein

[Term]
id: GO:0035968
name: obsolete regulation of sterol import by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sterol import, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:12077145]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of sterol import by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of sterol influx by regulation of transcription from Pol II promoter" EXACT [GOC:bf]
synonym: "regulation of sterol influx by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of sterol uptake by regulation of transcription from Pol II promoter" EXACT [GOC:bf]
synonym: "regulation of sterol uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0035969
name: obsolete positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of sterol import by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:0035970
name: peptidyl-threonine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]
subset: gocheck_obsoletion_candidate
is_a: GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0035971
name: peptidyl-histidine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine." [GOC:BHF, GOC:vk, PMID:12383260]
subset: gocheck_obsoletion_candidate
is_a: GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0035973
name: aggrephagy
namespace: biological_process
alt_id: GO:0035972
def: "The selective degradation of protein aggregates by macroautophagy." [GOC:autophagy, GOC:kmv, PMID:18508269, PMID:25062811]
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0035974
name: meiotic spindle pole body
namespace: cellular_component
def: "The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome." [GOC:vw, PMID:21775631]
is_a: GO:0005816 ! spindle pole body

[Term]
id: GO:0035975
name: obsolete carbamoyl phosphate catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [GOC:yaf, UniPathway:UPA00996]
comment: This term was obsoleted because it represents a molecular function.
synonym: "carbamoyl phosphate breakdown" EXACT [GOC:bf]
synonym: "carbamoyl phosphate catabolism" EXACT [GOC:bf]
synonym: "carbamoyl phosphate degradation" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0006526
consider: GO:0019856

[Term]
id: GO:0035976
name: transcription factor AP-1 complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes." [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor]
synonym: "Activating protein 1 complex" EXACT [GOC:rl]
synonym: "AP-1 complex" EXACT [GOC:rl]
synonym: "AP1 complex" EXACT [GOC:rl]
synonym: "transcription factor AP1 complex" EXACT [GOC:rl]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0035977
name: protein deglycosylation involved in glycoprotein catabolic process
namespace: biological_process
def: "The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein." [GOC:bf, GOC:vw]
subset: gocheck_obsoletion_candidate
is_a: GO:0006517 ! protein deglycosylation
relationship: part_of GO:0006516 ! glycoprotein catabolic process

[Term]
id: GO:0035978
name: obsolete histone H2A-S139 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone." [GOC:yaf, PMID:16061642]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A.x phosphorylation at S139" NARROW [GOC:bf, PMID:16061642]
is_obsolete: true
consider: GO:0035979

[Term]
id: GO:0035979
name: histone H2AXS139 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX." [GOC:yaf, PMID:11893489, PMID:16061642]
comment: Residue 1 of histone H2A is taken as the first residue following removal of the initiating Methionine (Met).
synonym: "histone H2AS139 kinase activity" RELATED []
synonym: "histone kinase activity (H2A-S139 specific)" RELATED []
synonym: "histone kinase activity (H2A.x-S139 specific)" NARROW [GOC:bf, PMID:16061642]
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0141003 ! histone H2AX kinase activity

[Term]
id: GO:0035980
name: obsolete invasive growth in response to nitrogen limitation
namespace: biological_process
def: "OBSOLETE. The growth of colonies in filamentous chains of cells as a result of a reduced availability of nitrogen." [GOC:vw]
comment: This term was made obsolete because the GO term 'pseudohyphal growth ; GO:0007124' describes growth under nitrogen-limiting conditions.
synonym: "invasive growth in response to nitrogen limitation" EXACT []
is_obsolete: true
consider: GO:0007124

[Term]
id: GO:0035981
name: tongue muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell." [CL:0002673, GOC:yaf, PMID:3393851]
is_a: GO:0098528 ! skeletal muscle fiber differentiation

[Term]
id: GO:0035982
name: obsolete age-dependent behavioral decline
namespace: biological_process
def: "OBSOLETE. A developmental process that arises as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:kmv, PMID:20523893]
comment: This term was made obsolete because it describes a phenotype.
synonym: "age-dependent behavioural decline" EXACT [GOC:bf]
synonym: "age-related behavioral decline" EXACT [GOC:kmv]
synonym: "behavioral aging" EXACT [GOC:kmv]
is_obsolete: true

[Term]
id: GO:0035983
name: response to trichostatin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [GOC:yaf, PMID:20181743]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0035984
name: cellular response to trichostatin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [GOC:yaf, PMID:20181743]
is_a: GO:0035983 ! response to trichostatin A
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0035985
name: senescence-associated heterochromatin focus
namespace: cellular_component
def: "A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468]
synonym: "SAHF" EXACT [GOC:yaf]
synonym: "senescence-associated heterochromatin foci" EXACT [PMID:15621527, PMID:21248468]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0035986
name: obsolete senescence-associated heterochromatin focus assembly
namespace: biological_process
def: "OBSOLETE. The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468]
comment: This term was obsoleted because there is no evidence that this is a distinct process; this should be captured as an extension.
synonym: "SAHF formation" EXACT [GOC:yaf]
synonym: "senescence-associated heterochromatin foci formation" EXACT [GOC:yaf]
synonym: "senescence-associated heterochromatin focus formation" EXACT []
is_obsolete: true
consider: GO:0031507

[Term]
id: GO:0035987
name: endodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332]
synonym: "endoderm cell differentiation" EXACT [CL:0000223]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001706 ! endoderm formation

[Term]
id: GO:0035988
name: chondrocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:yaf, PMID:21484705]
synonym: "cartilage cell proliferation" EXACT [CL:0000138]
synonym: "chondrocyte cell proliferation" EXACT [GOC:bf]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0035989
name: tendon development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043]
synonym: "sinew development" RELATED [UBERON:0000043]
is_a: GO:0061448 ! connective tissue development

[Term]
id: GO:0035990
name: tendon cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429]
synonym: "muscle attachment cell differentiation" EXACT [CL:0000388]
synonym: "tenocyte differentiation" RELATED [CL:0000388]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0035992 ! tendon formation

[Term]
id: GO:0035991
name: nitric oxide sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)." [GOC:kmv, PMID:21491957]
synonym: "NO sensor activity" EXACT []
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0035992
name: tendon formation
namespace: biological_process
def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035989 ! tendon development

[Term]
id: GO:0035993
name: deltoid tuberosity development
namespace: biological_process
def: "The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase." [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060173 ! limb development
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0035994
name: response to muscle stretch
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length." [GOC:BHF, GOC:vk, PMID:14583192]
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0035995
name: detection of muscle stretch
namespace: biological_process
def: "The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal." [PMID:14583192]
is_a: GO:0035994 ! response to muscle stretch
is_a: GO:0050982 ! detection of mechanical stimulus

[Term]
id: GO:0035996
name: rhabdomere microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projection on the surface of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]
is_a: GO:0005902 ! microvillus
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0035997
name: rhabdomere microvillus membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a microvillus of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]
is_a: GO:0031528 ! microvillus membrane
relationship: part_of GO:0033583 ! rhabdomere membrane
relationship: part_of GO:0035996 ! rhabdomere microvillus

[Term]
id: GO:0035998
name: obsolete 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [GOC:yaf, UniPathway:UPA00848]
comment: This term was obsoleted because it represents a molecular function.
synonym: "7,8-dihydroneopterin 3'-triphosphate anabolism" EXACT [GOC:bf]
synonym: "7,8-dihydroneopterin 3'-triphosphate biosynthesis" EXACT [GOC:bf]
synonym: "7,8-dihydroneopterin 3'-triphosphate formation" EXACT [GOC:bf]
synonym: "7,8-dihydroneopterin 3'-triphosphate synthesis" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0003933
consider: GO:0046656

[Term]
id: GO:0035999
name: tetrahydrofolate interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]
xref: MetaCyc:PWY-2201
is_a: GO:0006730 ! one-carbon metabolic process
is_a: GO:0046653 ! tetrahydrofolate metabolic process

[Term]
id: GO:0036000
name: mucocyst
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion." [GOC:mag, PMID:10723937, PMID:4629881]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0036001
name: 'de novo' pyridoxal 5'-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components." [GOC:bf, GOC:yaf, MetaCyc:PYRIDOXSYN-PWY]
synonym: "'de novo' PLP biosynthesis" EXACT [MetaCyc:PYRIDOXSYN-PWY]
synonym: "'de novo' pyridoxal 5'-phosphate anabolism" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal 5'-phosphate biosynthesis" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal 5'-phosphate formation" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal 5'-phosphate synthesis" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal phosphate biosynthetic process" BROAD [GOC:bf]
xref: MetaCyc:PYRIDOXSYN-PWY
is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process

[Term]
id: GO:0036002
name: pre-mRNA binding
namespace: molecular_function
def: "Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]
synonym: "protein-coding primary transcript binding" RELATED [SO:0000120]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0036003
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mcc]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0033554
consider: GO:0045944

[Term]
id: GO:0036004
name: GAF domain binding
namespace: molecular_function
def: "Binding to a GAF protein domain." [GOC:yaf, InterPro:IPR003018]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0036005
name: response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666]
synonym: "response to M-CSF" EXACT [GOC:bf, PMID:14687666]
synonym: "response to macrophage colony-stimulating factor stimulus" EXACT [GOC:dos]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0036006
name: cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666]
synonym: "cellular response to M-CSF stimulus" EXACT [GOC:bf, PMID:14687666]
synonym: "cellular response to macrophage colony-stimulating factor" EXACT [GOC:bf]
is_a: GO:0036005 ! response to macrophage colony-stimulating factor
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0036007
name: scintillon
namespace: cellular_component
def: "A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen." [GOC:mag, GOC:pr, PMID:4501583, PMID:5642469]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0036008
name: sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate." [GOC:bf, GOC:dgf, MetaCyc:SUCUTIL-PWY]
xref: MetaCyc:SUCUTIL-PWY
is_a: GO:0005987 ! sucrose catabolic process
is_a: GO:0006002 ! fructose 6-phosphate metabolic process
is_a: GO:0051156 ! glucose 6-phosphate metabolic process

[Term]
id: GO:0036009
name: protein-glutamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine." [GOC:imk, PMID:11847124]
synonym: "protein glutamine N-methylase activity" EXACT []
synonym: "protein glutamine N-methyltransferase activity" EXACT []
xref: Reactome:R-HSA-6800138 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0036010
name: protein localization to endosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an endosome." [GOC:yaf]
synonym: "protein localisation in endosome" EXACT [GOC:bf]
synonym: "protein localization in endosome" EXACT []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0036011
name: imaginal disc-derived leg segmentation
namespace: biological_process
def: "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
is_a: GO:0035285 ! appendage segmentation
relationship: part_of GO:0007480 ! imaginal disc-derived leg morphogenesis

[Term]
id: GO:0036012
name: cyanelle inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma." [GOC:aa, PMID:18976493]
synonym: "cyanelle inner envelope membrane" EXACT [PMID:18976493]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0033113 ! cyanelle membrane

[Term]
id: GO:0036013
name: cyanelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope." [GOC:aa]
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0033113 ! cyanelle membrane

[Term]
id: GO:0036014
name: cyanelle intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer." [GOC:aa]
synonym: "cyanelle envelope lumen" EXACT [GOC:bf]
synonym: "cyanelle periplasm" EXACT [PMID:18976493]
is_a: GO:0009529 ! plastid intermembrane space
relationship: part_of GO:0033112 ! cyanelle envelope

[Term]
id: GO:0036015
name: response to interleukin-3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf]
synonym: "response to IL-3" EXACT [GOC:bf]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0036016
name: cellular response to interleukin-3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf]
synonym: "cellular response to IL-3" EXACT [GOC:bf]
is_a: GO:0036015 ! response to interleukin-3
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0036017
name: response to erythropoietin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0036018
name: cellular response to erythropoietin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf]
is_a: GO:0036017 ! response to erythropoietin
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0036019
name: endolysosome
namespace: cellular_component
def: "An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991]
is_a: GO:0005764 ! lysosome
is_a: GO:0005768 ! endosome

[Term]
id: GO:0036020
name: endolysosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]
synonym: "endolysosomal membrane" EXACT [GOC:bf]
is_a: GO:0005765 ! lysosomal membrane
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0036019 ! endolysosome

[Term]
id: GO:0036021
name: endolysosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]
synonym: "endolysosomal lumen" EXACT [GOC:bf]
is_a: GO:0031904 ! endosome lumen
is_a: GO:0043202 ! lysosomal lumen
relationship: part_of GO:0036019 ! endolysosome

[Term]
id: GO:0036022
name: limb joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner." [GOC:bf]
synonym: "knee morphogenesis" NARROW [GOC:bf]
synonym: "leg joint morphogenesis" NARROW [GOC:bf]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0035108 ! limb morphogenesis

[Term]
id: GO:0036023
name: embryonic skeletal limb joint morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb." [GOC:bf, Wikipedia:Joint]
is_a: GO:0036022 ! limb joint morphogenesis
is_a: GO:0060272 ! embryonic skeletal joint morphogenesis
relationship: part_of GO:0030326 ! embryonic limb morphogenesis

[Term]
id: GO:0036024
name: protein C inhibitor-TMPRSS7 complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7." [GOC:ans, PMID:15853774]
synonym: "PCI-TMPRSS7 complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-TMPRSS7 complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-matriptase-3 complex" EXACT [PMID:15853774, PR:000016461]
synonym: "protein C inhibitor-transmembrane protease serine 7 complex" EXACT [PR:000016461]
synonym: "serpin A5-TMPRSS7 complex" EXACT [PR:000014685]
synonym: "SERPINA5-TMPRSS7 complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0036025
name: protein C inhibitor-TMPRSS11E complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E." [GOC:ans, PMID:15328353]
synonym: "PCI-TMPRSS11E complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-TMPRSS11E complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-transmembrane protease serine 11E complex" EXACT [PR:000016451]
synonym: "serpin A5-TMPRSS11E complex" EXACT [PR:000014685]
synonym: "SERPINA5-TMPRSS11E complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0036026
name: protein C inhibitor-PLAT complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator." [GOC:ans, PMID:10340997]
synonym: "PCI-PLAT complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-PLAT complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-tissue-type plasminogen activator complex" EXACT [PMID:10340997, PR:000012825]
synonym: "protein C inhibitor-tPA complex" EXACT [PMID:10340997, PR:000012825]
synonym: "serpin A5-PLAT complex" EXACT [PR:000014685]
synonym: "SERPINA5-PLAT complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0036027
name: protein C inhibitor-PLAU complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator." [GOC:ans, PMID:10340997, PMID:3501295, PMID:8536714]
synonym: "PCI-PLAU complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-PLAU complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-U-plasminogen activator complex" EXACT [PR:000012826]
synonym: "protein C inhibitor-uPA complex" EXACT [PR:000012826]
synonym: "protein C inhibitor-urokinase-type plasminogen activator complex" EXACT [PR:000012826]
synonym: "serpin A5-PLAU complex" EXACT [PR:000014685]
synonym: "SERPINA5-PLAU complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0036028
name: protein C inhibitor-thrombin complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin." [GOC:ans, PMID:6323392]
synonym: "PCI-thrombin complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-thrombin complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-coagulation factor II complex" EXACT [PR:000007299]
synonym: "protein C inhibitor-F2 complex" EXACT [PR:000007299]
synonym: "serpin A5-thrombin complex" EXACT [PR:000014685]
synonym: "SERPINA5-thrombin complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0036029
name: protein C inhibitor-KLK3 complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen." [GOC:ans, PMID:1725227]
synonym: "PCI-KLK3 complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-KLK3 complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-kallikrein-3 complex" EXACT [PR:000003015]
synonym: "protein C inhibitor-prostate-specific antigen complex" EXACT [PR:000003015]
synonym: "serpin A5-KLK3 complex" EXACT [PR:000014685]
synonym: "SERPINA5-KLK3 complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0036030
name: protein C inhibitor-plasma kallikrein complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein." [GOC:ans, PMID:2844223, PMID:8536714]
synonym: "PCI-plasma kallikrein complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-plasma kallikrein complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-KLKB1 complex" EXACT [PR:000009420]
synonym: "serpin A5-plasma kallikrein complex" EXACT [PR:000014685]
synonym: "SERPINA5-plasma kallikrein complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0036031
name: obsolete recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "OBSOLETE. The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript." [GOC:bf, GOC:rb, PMID:10594013]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "capping enzyme targeting to RNA polymerase II" EXACT [PMID:10594013]
synonym: "recruitment of guanylyltransferase to RNA polymerase II holoenzyme complex" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036032
name: neural crest cell delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube." [CL:0000333, PMID:17076275]
synonym: "neural crest cell emigration" EXACT [PMID:17076275]
synonym: "neural crest cell individualization" EXACT [PMID:17076275]
synonym: "neural crest cell segregation" RELATED [PMID:17076275]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0036033
name: mediator complex binding
namespace: molecular_function
def: "Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:18391015]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0036034
name: mediator complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:17641689]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0036035
name: osteoclast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf]
synonym: "osteoclast cell development" EXACT [GOC:bf]
is_a: GO:0061515 ! myeloid cell development
is_a: GO:0098751 ! bone cell development
relationship: part_of GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0036036
name: cardiac neural crest cell delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube." [GOC:hjd, PMID:17076275, PMID:18539270, PMID:20490374]
is_a: GO:0036032 ! neural crest cell delamination

[Term]
id: GO:0036037
name: CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000625, GOC:yaf]
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0036038
name: MKS complex
namespace: cellular_component
def: "A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane." [GOC:cilia, GOC:sp, PMID:21422230, PMID:21565611, PMID:21725307, PMID:22179047, PMID:25869670, PMID:26595381, PMID:26982032]
comment: Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
synonym: "B9 complex" NARROW []
synonym: "MKS module" EXACT []
synonym: "TCTN-B9D complex" BROAD []
synonym: "tectonic complex" NARROW []
synonym: "tectonic-like complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0035869 ! ciliary transition zone

[Term]
id: GO:0036039
name: curcumin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the polyphenol, curcumin." [PMID:21467222]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolic process" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolism" EXACT [GOC:obol]
synonym: "curcumin metabolism" EXACT [GOC:obol]
synonym: "diferuloylmethane metabolic process" EXACT [GOC:obol]
synonym: "diferuloylmethane metabolism" EXACT [GOC:obol]
synonym: "turmeric yellow metabolic process" EXACT [GOC:obol]
synonym: "turmeric yellow metabolism" EXACT [GOC:obol]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0036040
name: curcumin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin." [PMID:21467222]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione breakdown" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolic process" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolism" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione degradation" EXACT [GOC:obol]
synonym: "curcumin breakdown" EXACT [GOC:obol]
synonym: "curcumin catabolism" EXACT [GOC:obol]
synonym: "curcumin degradation" EXACT [GOC:obol]
synonym: "diferuloylmethane breakdown" EXACT [GOC:obol]
synonym: "diferuloylmethane catabolic process" EXACT [GOC:obol]
synonym: "diferuloylmethane catabolism" EXACT [GOC:obol]
synonym: "diferuloylmethane degradation" EXACT [GOC:obol]
synonym: "turmeric yellow breakdown" EXACT [GOC:obol]
synonym: "turmeric yellow catabolic process" EXACT [GOC:obol]
synonym: "turmeric yellow catabolism" EXACT [GOC:obol]
synonym: "turmeric yellow degradation" EXACT [GOC:obol]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0036039 ! curcumin metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0036041
name: long-chain fatty acid binding
namespace: molecular_function
def: "Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:pm, PMID:12641450]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long chain fatty acid binding" EXACT [PMID:12641450]
is_a: GO:0005504 ! fatty acid binding

[Term]
id: GO:0036042
name: long-chain fatty acyl-CoA binding
namespace: molecular_function
def: "Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:krc, GOC:pm]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acyl-coenyme A binding" EXACT []
is_a: GO:0000062 ! fatty-acyl-CoA binding

[Term]
id: GO:0036043
name: obsolete microspike
namespace: cellular_component
def: "OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735]
comment: This term was made obsolete because it accidentally reused an existing id. See replacement term GO:0044393.
synonym: "microspike" EXACT []
is_obsolete: true
replaced_by: GO:0044393

[Term]
id: GO:0036044
name: obsolete protein malonylation
namespace: biological_process
def: "OBSOLETE. The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [GOC:sp]
comment: This term was made obsolete because it accidentally shared the same ID as negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway by negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity. New id is GO:0044394.
synonym: "protein malonylation" EXACT []
is_obsolete: true
replaced_by: GO:0044394

[Term]
id: GO:0036045
name: obsolete peptidyl-lysine malonylation
namespace: biological_process
def: "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568]
comment: This term was made obsolete because it accidentally reused an existing id. See replacement term GO:0044392.
synonym: "lysine malonylation" EXACT [PMID:21908771]
synonym: "peptidyl-lysine malonylation" EXACT []
xref: RESID:AA0568
is_obsolete: true

[Term]
id: GO:0036046
name: protein demalonylation
namespace: biological_process
def: "The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide." [GOC:sp, PMID:22076378]
subset: gocheck_obsoletion_candidate
is_a: GO:0035601 ! protein deacylation

[Term]
id: GO:0036047
name: peptidyl-lysine demalonylation
namespace: biological_process
def: "The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378]
subset: gocheck_obsoletion_candidate
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0036046 ! protein demalonylation

[Term]
id: GO:0036048
name: protein desuccinylation
namespace: biological_process
def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein." [GOC:sp, PMID:22076378]
subset: gocheck_obsoletion_candidate
is_a: GO:0035601 ! protein deacylation

[Term]
id: GO:0036049
name: peptidyl-lysine desuccinylation
namespace: biological_process
def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378]
subset: gocheck_obsoletion_candidate
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0036048 ! protein desuccinylation

[Term]
id: GO:0036050
name: obsolete peptidyl-lysine succinylation
namespace: biological_process
def: "OBSOLETE. The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21151122, RESID:AA0545]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0036051
name: protein localization to trailing edge
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement." [GOC:pf, GOC:pg]
synonym: "protein localisation to trailing edge" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0036052
name: protein localization to uropod
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell." [GOC:add, GOC:pf, ISBN:0781735149, PMID:12714569, PMID:12787750]
synonym: "protein localisation to uropod" EXACT [GOC:mah]
is_a: GO:0036051 ! protein localization to trailing edge

[Term]
id: GO:0036053
name: glomerular endothelium fenestra
namespace: cellular_component
def: "A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes." [GOC:cjm, MP:0011454, PMID:19129259]
synonym: "GEnC fenestration" EXACT [PMID:19129259]
synonym: "glomerular endothelial cell fenestration" EXACT [PMID:19129259]
is_a: GO:0046930 ! pore complex

[Term]
id: GO:0036054
name: protein-malonyllysine demalonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378]
synonym: "peptidyl-malonyllysine demalonylase activity" EXACT []
synonym: "protein lysine demalonylation activity" EXACT [PMID:21908771]
synonym: "protein malonyl lysine demalonylation activity" EXACT [GOC:bf]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0036055
name: protein-succinyllysine desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:sp, PMID:22076378]
comment: This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
synonym: "peptidyl-succinyllysine desuccinylase activity" EXACT []
synonym: "succinyl lysine desuccinylase activity" BROAD [GOC:bf]
synonym: "succinyllysine desuccinylase activity" BROAD []
xref: RHEA:47668
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0036056
name: filtration diaphragm
namespace: cellular_component
def: "A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0036057
name: slit diaphragm
namespace: cellular_component
def: "A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094]
is_a: GO:0036056 ! filtration diaphragm

[Term]
id: GO:0036058
name: filtration diaphragm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929]
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0036059
name: nephrocyte diaphragm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
is_a: GO:0034333 ! adherens junction assembly
is_a: GO:0036058 ! filtration diaphragm assembly

[Term]
id: GO:0036060
name: slit diaphragm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:20633639]
is_a: GO:0036058 ! filtration diaphragm assembly

[Term]
id: GO:0036061
name: muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells." [GOC:sart, PMID:19793885]
synonym: "muscle cell attraction" RELATED [GOC:bf]
synonym: "muscle cell chemotaxis towards tendon cell" EXACT [GOC:bf, GOC:sart]
is_a: GO:0014812 ! muscle cell migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0036062
name: presynaptic periactive zone
namespace: cellular_component
def: "A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development." [GOC:sart, PMID:10976048, PMID:18439406]
synonym: "periactive zone" EXACT [PMID:10976048, PMID:18439406]
synonym: "pre-synaptic periactive zone" EXACT []
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane

[Term]
id: GO:0036063
name: acroblast
namespace: cellular_component
def: "A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle." [GOC:sart, PMID:19934220]
comment: See also the fly_anatomy.ontology term 'acroblast ; FBbt:00004947'.
synonym: "spermatid acroblast" EXACT [GOC:bf]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0036064
name: ciliary basal body
namespace: cellular_component
alt_id: GO:0005932
def: "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]
comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
synonym: "basal body" BROAD []
synonym: "cilial basal body" EXACT []
synonym: "cilium basal body" EXACT [GOC:bf]
synonym: "kinetosome" EXACT [PMID:11125699]
synonym: "microtubule basal body" EXACT []
xref: NIF_Subcellular:sao11978067
is_a: GO:0005815 ! microtubule organizing center
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0036065
name: fucosylation
namespace: biological_process
def: "The covalent attachment of a fucosyl group to an acceptor molecule." [GOC:sart, PMID:19948734]
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0036066
name: protein O-linked fucosylation
namespace: biological_process
def: "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734]
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0036065 ! fucosylation

[Term]
id: GO:0036067
name: light-dependent chlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light." [GOC:yaf, PMID:12242396]
synonym: "light dependent chlorophyll biosynthetic process" EXACT [GOC:yaf]
synonym: "light-dependent chlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-dependent chlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-dependent chlorophyll formation" EXACT [GOC:bf]
synonym: "light-dependent chlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0015995 ! chlorophyll biosynthetic process

[Term]
id: GO:0036068
name: light-independent chlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light." [GOC:yaf, PMID:12242396]
synonym: "light independent chlorophyll biosynthetic process" EXACT [GOC:yaf]
synonym: "light-independent chlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-independent chlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-independent chlorophyll formation" EXACT [GOC:bf]
synonym: "light-independent chlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0015995 ! chlorophyll biosynthetic process

[Term]
id: GO:0036069
name: light-dependent bacteriochlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396]
synonym: "light dependent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll formation" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process
is_a: GO:0036067 ! light-dependent chlorophyll biosynthetic process

[Term]
id: GO:0036070
name: light-independent bacteriochlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396]
synonym: "light independent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll formation" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process
is_a: GO:0036068 ! light-independent chlorophyll biosynthetic process

[Term]
id: GO:0036071
name: N-glycan fucosylation
namespace: biological_process
def: "The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [GOC:sart, PMID:19948734]
synonym: "glycoprotein fucosylation" RELATED [GOC:bf]
is_a: GO:0036065 ! fucosylation

[Term]
id: GO:0036072
name: direct ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034]
is_a: GO:0001503 ! ossification

[Term]
id: GO:0036073
name: perichondral ossification
namespace: biological_process
def: "Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage." [GO_REF:0000034]
is_a: GO:0001957 ! intramembranous ossification

[Term]
id: GO:0036074
name: metaplastic ossification
namespace: biological_process
def: "Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division." [GO_REF:0000034]
comment: Some intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "metaplasia" RELATED [GO_REF:0000034]
is_a: GO:0036072 ! direct ossification

[Term]
id: GO:0036075
name: replacement ossification
namespace: biological_process
def: "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." [GO_REF:0000034]
synonym: "indirect ossification" EXACT [GO_REF:0000034]
is_a: GO:0001503 ! ossification

[Term]
id: GO:0036076
name: ligamentous ossification
namespace: biological_process
def: "Ossification wherein bone tissue forms within ligamentous tissue." [GO_REF:0000034]
comment: Ligamentous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance.
is_a: GO:0001503 ! ossification

[Term]
id: GO:0036077
name: intratendonous ossification
namespace: biological_process
def: "Ossification wherein bone tissue forms within tendonous tissue." [GO_REF:0000034]
comment: Tendonous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance.
is_a: GO:0001503 ! ossification

[Term]
id: GO:0036078
name: minus-end specific microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from the minus end of a microtubule." [GOC:sart, PMID:17452528]
is_a: GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0036080
name: purine nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:sart, PMID:19948734]
is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0036081
name: extracellular ammonia-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
synonym: "extracellular ammonia-gated ion channel activity" BROAD []
synonym: "ionotropic ammonia receptor activity" RELATED [PMID:19135896]
is_a: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity

[Term]
id: GO:0036082
name: extracellular phenylacetaldehyde-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
synonym: "extracellular phenylacetaldehyde-gated ion channel activity" BROAD []
synonym: "ionotropic phenylacetaldehyde receptor activity" RELATED [PMID:19135896]
is_a: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity

[Term]
id: GO:0036083
name: obsolete positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9927444]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0036084
name: GDP-fucose import into endoplasmic reticulum lumen
namespace: biological_process
def: "The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]
synonym: "GDP-fucose import into endoplasmic reticulum" EXACT [GOC:bf]
synonym: "GDP-fucose transport across endoplasmic reticulum membrane" EXACT [GOC:bf]
synonym: "GDP-fucose transport into endoplasmic reticulum lumen" EXACT [GOC:sart]
is_a: GO:0015783 ! GDP-fucose transmembrane transport
is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport

[Term]
id: GO:0036085
name: GDP-fucose import into Golgi lumen
namespace: biological_process
def: "The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]
synonym: "GDP-fucose import into Golgi" EXACT [GOC:bf]
synonym: "GDP-fucose transport across Golgi membrane" EXACT [GOC:bf]
synonym: "GDP-fucose transport into Golgi lumen" EXACT [GOC:sart]
is_a: GO:0015783 ! GDP-fucose transmembrane transport
is_a: GO:0140820 ! cytosol to Golgi apparatus transport

[Term]
id: GO:0036086
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:cjk]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0010106
consider: GO:0045944

[Term]
id: GO:0036087
name: glutathione synthase complex
namespace: cellular_component
def: "A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer." [GOC:al, PMID:12734194, PMID:14990577, PMID:1958212]
synonym: "glutathione synthetase complex" EXACT [PMID:12734194, PMID:14990577, PMID:1958212]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0036088
name: D-serine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:imk]
synonym: "D-serine breakdown" EXACT [GOC:bf]
synonym: "D-serine catabolism" EXACT [GOC:bf]
synonym: "D-serine degradation" EXACT [GOC:bf]
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0070178 ! D-serine metabolic process

[Term]
id: GO:0036089
name: cleavage furrow formation
namespace: biological_process
def: "Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell." [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590]
comment: Consider also annotating to 'establishment of contractile ring localization involved in cell cycle cytokinesis ; GO:0032188'.
synonym: "cleavage furrow positioning" NARROW [PMID:14757750]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0099024 ! plasma membrane invagination
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0036090
name: cleavage furrow ingression
namespace: biological_process
def: "Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468]
comment: Consider also annotating to 'contractile ring contraction involved in cell cycle cytokinesis ; GO:0000916'.
synonym: "cleavage furrow contraction" EXACT [PMID:3413069]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0099024 ! plasma membrane invagination
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0036091
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:rn, PMID:14978214, PMID:18439143]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0034599
consider: GO:0045944

[Term]
id: GO:0036092
name: phosphatidylinositol-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [GOC:al, GOC:vw]
synonym: "phosphatidylinositol-3-phosphate anabolism" EXACT [GOC:bf]
synonym: "phosphatidylinositol-3-phosphate biosynthesis" EXACT [GOC:bf]
synonym: "phosphatidylinositol-3-phosphate formation" EXACT [GOC:bf]
synonym: "phosphatidylinositol-3-phosphate synthesis" EXACT [GOC:bf]
synonym: "PI(3)P biosynthesis" EXACT []
synonym: "PtdIns3P biosynthesis" EXACT []
is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process

[Term]
id: GO:0036093
name: germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0036094
name: small molecule binding
namespace: molecular_function
def: "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_agr
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
is_a: GO:0005488 ! binding

[Term]
id: GO:0036095
name: obsolete positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of invasive growth as a result of deprivation of glucose, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:jh, PMID:14668363]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transcriptional activation of genes involved in invasive growth" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036096
name: obsolete 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing
namespace: molecular_function
def: "OBSOLETE. Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292]
comment: This term was made obsolete because it is not real a process, and was created accidentally.
synonym: "3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing" EXACT []
synonym: "exonucleolytic trimming to generate 3' end of miRNA from pre-miRNA" RELATED [GOC:sart]
is_obsolete: true

[Term]
id: GO:0036097
name: obsolete pre-miRNA 3'-end processing
namespace: biological_process
def: "OBSOLETE. Any process involved in forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292]
comment: This term was made obsolete because it is not real a process, and was created accidentally.
synonym: "microRNA 3'-end processing" BROAD [PMID:22055292]
synonym: "miRNA 3'-end processing" BROAD [PMID:22055292]
synonym: "pre-miRNA 3'-end processing" EXACT []
is_obsolete: true

[Term]
id: GO:0036098
name: male germ-line stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of male germ-line stem cells." [GOC:sart, PMID:21752937]
is_a: GO:0030718 ! germ-line stem cell population maintenance

[Term]
id: GO:0036099
name: female germ-line stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
is_a: GO:0030718 ! germ-line stem cell population maintenance

[Term]
id: GO:0036100
name: leukotriene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:yaf]
synonym: "leukotriene breakdown" EXACT [GOC:bf]
synonym: "leukotriene catabolism" EXACT [GOC:bf]
synonym: "leukotriene degradation" EXACT [GOC:bf]
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0036101
name: leukotriene B4 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:yaf, PMID:9799565]
synonym: "leukotriene B4 breakdown" EXACT [GOC:bf]
synonym: "leukotriene B4 catabolism" EXACT [GOC:bf]
synonym: "leukotriene B4 degradation" EXACT [GOC:bf]
synonym: "LTB4 catabolism" EXACT []
is_a: GO:0036100 ! leukotriene catabolic process
is_a: GO:0036102 ! leukotriene B4 metabolic process
is_a: GO:0042758 ! long-chain fatty acid catabolic process
is_a: GO:1901523 ! icosanoid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0036102
name: leukotriene B4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:bf]
synonym: "LTB4 metabolism" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0036103
name: Kdo2-lipid A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:bf]
synonym: "Kdo2-lipid A metabolism" EXACT [GOC:bf]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:0036104
name: Kdo2-lipid A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:yaf, PMID:21106097]
synonym: "3-deoxy-d-manno-octulosonic acid-lipid A biosynthesis" EXACT [PMID:24838025]
synonym: "Kdo2-lipid A anabolism" EXACT [GOC:bf]
synonym: "Kdo2-lipid A biosynthesis" EXACT [GOC:bf]
synonym: "Kdo2-lipid A formation" EXACT [GOC:bf]
synonym: "Kdo2-lipid A synthesis" EXACT [GOC:bf]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0036103 ! Kdo2-lipid A metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:1901271 ! lipooligosaccharide biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process

[Term]
id: GO:0036105
name: peroxisome membrane class-1 targeting sequence binding
namespace: molecular_function
def: "Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner." [GOC:pm, PMID:14709540, PMID:17020786]
comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence.
synonym: "class 1 mPTS binding" EXACT [PMID:14709540]
synonym: "PEX19-dependent mPTS binding" RELATED [PMID:14709540]
is_a: GO:0033328 ! peroxisome membrane targeting sequence binding

[Term]
id: GO:0036106
name: peroxisome membrane class-2 targeting sequence binding
namespace: molecular_function
def: "Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner." [GOC:pm, PMID:14709540, PMID:17020786]
comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence.
synonym: "class 2 mPTS binding" EXACT [PMID:14709540]
synonym: "PEX19-independent mPTS binding" RELATED [PMID:14709540]
is_a: GO:0033328 ! peroxisome membrane targeting sequence binding

[Term]
id: GO:0036107
name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [PMID:15695810]
synonym: "4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate metabolic process" EXACT []
synonym: "undecaprenyl phosphate alpha-L-Ara4N metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0036108
name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [GOC:yaf, PMID:15695810]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate anabolism" EXACT [GOC:bf]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthesis" EXACT [GOC:bf]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate formation" EXACT [GOC:bf]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate synthesis" EXACT [GOC:bf]
synonym: "undecaprenyl phosphate alpha-L-Ara4N biosynthesis" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0036107 ! 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process

[Term]
id: GO:0036109
name: alpha-linolenic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [PMID:15538555]
synonym: "ALA metabolism" EXACT [CHEBI:27432]
synonym: "alpha-linolenic acid metabolism" EXACT [GOC:bf]
xref: Wikipedia:Linoleic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0036110
name: cellular response to inositol starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol." [GOC:al, PMID:19606215]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0036111
name: very long-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:pm]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very long-chain fatty acyl CoA metabolic process" EXACT [GOC:bf]
synonym: "very long-chain fatty acyl-CoA metabolism" EXACT [GOC:bf]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:0036112
name: medium-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [GOC:pm]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "medium-chain fatty acyl CoA metabolic process" EXACT [GOC:bf]
synonym: "medium-chain fatty acyl-CoA metabolism" EXACT [GOC:bf]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:0036113
name: very long-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:pm]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "very long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "very long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0036111 ! very long-chain fatty-acyl-CoA metabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process

[Term]
id: GO:0036114
name: medium-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [GOC:pm]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "medium-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "medium-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "medium-chain fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0036112 ! medium-chain fatty-acyl-CoA metabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process

[Term]
id: GO:0036115
name: fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [PMID:10578051]
synonym: "fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process

[Term]
id: GO:0036116
name: long-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:pm]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process

[Term]
id: GO:0036117
name: hyaluranon cable
namespace: cellular_component
def: "A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089]
synonym: "HA cable" EXACT [PMID:16900089]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0036118
name: hyaluranon cable assembly
namespace: biological_process
def: "A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089]
synonym: "HA cable assembly" EXACT [PMID:16900089]
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0036119
name: response to platelet-derived growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf]
synonym: "response to PDGF stimulus" EXACT [GOC:bf]
synonym: "response to platelet-derived growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:0036120
name: cellular response to platelet-derived growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf]
synonym: "cellular response to PDGF stimulus" EXACT [GOC:bf]
is_a: GO:0036119 ! response to platelet-derived growth factor
is_a: GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0036121
name: double-stranded DNA helicase activity
namespace: molecular_function
alt_id: GO:0033676
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix." [GOC:kmv]
synonym: "double-stranded DNA-dependent ATP-dependent DNA helicase activity" EXACT []
synonym: "double-stranded DNA-dependent ATPase activity" EXACT []
synonym: "dsDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:kmv]
synonym: "dsDNA-dependent ATPase activity" EXACT []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0036122
name: BMP binding
namespace: molecular_function
def: "Binding to a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951]
synonym: "bone morphogenetic protein binding" EXACT [GOC:bf]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0036123
name: obsolete histone H3-K9 dimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone." [GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K9 dimethylation" EXACT []
synonym: "histone lysine H3 K9 dimethylation" EXACT []
is_obsolete: true

[Term]
id: GO:0036124
name: obsolete histone H3-K9 trimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone." [GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0036125
name: fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def: "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743]
comment: For fatty acid beta-oxidation multienzyme complexes located in the mitochondrial matrix, consider instead the term 'mitochondrial fatty acid beta-oxidation multienzyme complex ; GO:0016507'.
is_a: GO:1990204 ! oxidoreductase complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0036126
name: sperm flagellum
namespace: cellular_component
def: "A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is always 'flagellum', hence the primary term name, but the cilium parentage is deliberate.
synonym: "sperm cilium" EXACT []
synonym: "sperm tail" EXACT [GOC:sart]
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0036127
name: 3-sulfino-L-alanine binding
namespace: molecular_function
def: "Binding to 3-sulfino-L-alanine (cysteine sulfinate)." [GOC:al, PMID:8346915]
synonym: "cysteine sulfinate binding" EXACT [GOC:al]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0036128
name: CatSper complex
namespace: cellular_component
def: "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]
synonym: "CATSPER channel" EXACT [PMID:21224844]
synonym: "CatSper channel complex" EXACT [PMID:17478420]
is_a: GO:0005891 ! voltage-gated calcium channel complex

[Term]
id: GO:0036129
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:al]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:0036130
name: prostaglandin H2 endoperoxidase reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)." [GOC:mw, KEGG_REACTION:R02264, PMID:10622721, PMID:14979715, PMID:16475787]
synonym: "PGH2 9,11-endoperoxidase" EXACT [PMID:12664595]
synonym: "PGH2 9-,11-endoperoxide reductase" EXACT [PMID:12432932]
xref: KEGG_REACTION:R02264
xref: Reactome:R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3"
xref: RHEA:45312
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036131
name: prostaglandin D2 11-ketoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+." [PMID:1504718, PMID:3862115, RHEA:45316]
synonym: "PGD2 11-ketoreductase" EXACT [PMID:14996743]
synonym: "prostaglandin 11-keto reductase" EXACT [PMID:7248318]
xref: KEGG_REACTION:R02799
xref: Reactome:R-HSA-2161614 "PGD2 is reduced to 11-epi-PGF2a by AKRIC3"
xref: RHEA:45316
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036132
name: obsolete 13-prostaglandin reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [GOC:mw, PMID:17449869]
comment: This term was obsoleted because it represents the same activity as 15-oxoprostaglandin 13-oxidase activity ; GO:0047522.
synonym: "15-oxoprostaglandin 13-reductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047522

[Term]
id: GO:0036133
name: 11-hydroxythromboxane B2 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+." [GOC:mw, KEGG_REACTION:R05060, PMID:3461463, PMID:3823488, PMID:8200461]
comment: Note that the KEGG_REACTION:R05060 reaction does not stipulate the acceptor group, and is therefore slightly more general than the activity described by GO:0036133.
synonym: "NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity" EXACT [PMID:1632314]
xref: KEGG_REACTION:R05060
xref: Reactome:R-HSA-2161732 "TXB2 is converted to 11dh-TXB2 by TXDH"
xref: RHEA:52312
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036134
name: 12-hydroxyheptadecatrienoic acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)." [GOC:mw, PMID:11297515]
synonym: "prostaglandin H2 degradation activity" RELATED [GOC:mw]
xref: Reactome:R-HSA-2161613 "PGH2 is degraded to 12S-HHT and MDA by TBXAS1"
xref: RHEA:48644
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036135
name: Schwann cell migration
namespace: biological_process
def: "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintenance and function." [CL:0002573, PMID:20335460]
is_a: GO:0008347 ! glial cell migration

[Term]
id: GO:0036136
name: obsolete kynurenine-oxaloacetate transaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate." [GOC:pde, PMID:15606768, PMID:4149765]
comment: This term was obsoleted because there is no evidence that this reaction exists.
synonym: "L-kynurenine-oxaloacetate transaminase activity" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0016212

[Term]
id: GO:0036137
name: obsolete kynurenine aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid." [GOC:pde]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "kynurenine-oxo-acid transaminase activity" NARROW [GOC:bf]
synonym: "L-kynurenine transaminase activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036138
name: obsolete peptidyl-histidine hydroxylation
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine." [GOC:reh, PMID:21251231]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0036139
name: peptidyl-histidine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2." [PMID:21251231, RHEA:54256]
synonym: "protein histidyl hydroxylase" BROAD []
synonym: "protein-L-histidine (3S)-3-hydroxylase" EXACT []
xref: EC:1.14.11.79
xref: MetaCyc:RXN-22839
xref: Reactome:R-HSA-9630967 "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A"
xref: Reactome:R-HSA-9630993 "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8"
xref: RHEA:54256
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0036140
name: [protein]-asparagine 3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0102113
def: "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2." [GOC:reh, PMID:12215170, RHEA:54260]
synonym: "hypoxia-inducible factor-asparagine oxygenase activity" NARROW []
synonym: "peptidyl-asparagine 3-dioxygenase activity" EXACT []
xref: RHEA:54260
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0036141
name: obsolete L-phenylalanine-oxaloacetate transaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate." [GOC:pde, PMID:15606768]
comment: This term was obsoleted because it represents the same activity as L-phenylalanine-2-oxoglutarate transaminase activity ; GO:0080130.
synonym: "L-phenylalanine:oxaloacetate transaminase activity" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0080130

[Term]
id: GO:0036143
name: kringle domain binding
namespace: molecular_function
def: "Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." [GOC:yaf, Wikipedia:Kringle_domain]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0036145
name: dendritic cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316]
synonym: "DC homeostasis" RELATED [PMID:19176316]
is_a: GO:0001776 ! leukocyte homeostasis

[Term]
id: GO:0036146
name: cellular response to mycotoxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:di, PMID:20548963]
is_a: GO:0010046 ! response to mycotoxin
is_a: GO:0097237 ! cellular response to toxic substance

[Term]
id: GO:0036147
name: rumination
namespace: biological_process
def: "A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again." [GOC:maf, Wikipedia:Rumination]
synonym: "digestive rumination" EXACT [Wikipedia:Rumination]
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0036148
name: phosphatidylglycerol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15485873, PMID:18458083]
synonym: "phosphatidylglycerol acyl-chain remodelling" EXACT []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process

[Term]
id: GO:0036149
name: phosphatidylinositol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [GOC:mw, PMID:18094042, PMID:18772128]
synonym: "phosphatidylinositol acyl-chain remodelling" EXACT []
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0036150
name: phosphatidylserine acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18287005, PMID:18458083]
synonym: "phosphatidyl-L-serine acyl-chain remodeling" EXACT []
synonym: "phosphatidylserine acyl-chain remodelling" EXACT []
is_a: GO:0006658 ! phosphatidylserine metabolic process

[Term]
id: GO:0036151
name: phosphatidylcholine acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18195019, PMID:18458083]
synonym: "phosphatidylcholine acyl-chain remodelling" EXACT []
is_a: GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0036152
name: phosphatidylethanolamine acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18287005, PMID:18458083]
synonym: "phosphatidylethanolamine acyl-chain remodelling" EXACT []
is_a: GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0036153
name: triglyceride acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929]
synonym: "triacylglycerol acyl-chain remodeling" EXACT [GOC:mw, KEGG:C00422]
synonym: "triglyceride acyl-chain remodelling" EXACT []
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0036155 ! acylglycerol acyl-chain remodeling

[Term]
id: GO:0036154
name: diacylglycerol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929]
synonym: "diacylglycerol acyl-chain remodelling" EXACT []
synonym: "diglyceride acyl-chain remodeling" EXACT [GOC:mw, KEGG:C00165]
is_a: GO:0036155 ! acylglycerol acyl-chain remodeling
is_a: GO:0046339 ! diacylglycerol metabolic process

[Term]
id: GO:0036155
name: acylglycerol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929]
synonym: "acylglycerol acyl-chain remodelling" EXACT []
synonym: "glyceride acyl-chain remodeling" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0036156
name: inner dynein arm
namespace: cellular_component
def: "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092]
synonym: "inner dynein arm complex" EXACT []
is_a: GO:0005858 ! axonemal dynein complex

[Term]
id: GO:0036157
name: outer dynein arm
namespace: cellular_component
def: "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174]
synonym: "outer dynein arm complex" EXACT []
is_a: GO:0005858 ! axonemal dynein complex

[Term]
id: GO:0036158
name: outer dynein arm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]
synonym: "ODA assembly" EXACT [PMID:19944400]
is_a: GO:0070286 ! axonemal dynein complex assembly

[Term]
id: GO:0036159
name: inner dynein arm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]
synonym: "IDA assembly" EXACT [PMID:19944400]
is_a: GO:0070286 ! axonemal dynein complex assembly

[Term]
id: GO:0036160
name: melanocyte-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone]
synonym: "MSH secretion" EXACT [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0036161
name: calcitonin secretion
namespace: biological_process
def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0036162
name: oxytocin production
namespace: biological_process
def: "The appearance of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG, due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior. It also acts as a neurotransmitter in the brain." [GOC:cjm, Wikipedia:Oxytocin]
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular oxytocin levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting oxytocin molecules, or increased conversion from precursor molecules.
synonym: "oxytocin biosynthesis" NARROW []
synonym: "oxytocin secretion" NARROW []
is_a: GO:0010467 ! gene expression

[Term]
id: GO:0036163
name: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2." [GOC:mw, KEGG_REACTION:R06866, PMID:620805, PMID:7028108]
xref: KEGG_REACTION:R06866
xref: RHEA:44768
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0036164
name: cell-abiotic substrate adhesion
namespace: biological_process
def: "The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules." [GOC:di]
synonym: "cell-abiotic surface adhesion" RELATED [GOC:di]
is_a: GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0036165
name: invasive growth in response to heat
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of an increase in temperature." [GOC:di, PMID:22365851]
synonym: "invasive growth in response to elevated temperature" EXACT [PMID:22365851]
synonym: "invasive growth in response to high temperature" EXACT [PMID:22365851]
synonym: "invasive growth in response to temperature stimulus" BROAD [GOC:di]
is_a: GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
is_a: GO:0036267 ! invasive filamentous growth

[Term]
id: GO:0036166
name: phenotypic switching
namespace: biological_process
def: "A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues." [GOC:bf, GOC:di, PMID:12443899, PMID:22406749, PMID:8456504, Wikipedia:Phenotypic_switching]
comment: Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
synonym: "phenotypic dimorphism" RELATED [Wikipedia:Phenotypic_switching]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0036167
name: obsolete phenotypic switching in response to host
namespace: biological_process
def: "OBSOLETE. A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:di, PMID:16696644, Wikipedia:Phenotypic_switching]
comment: This term was obsoleted because it represents the same process as phenotypic switching ; GO:0036166, but under a specific condition.
is_obsolete: true
replaced_by: GO:0036166

[Term]
id: GO:0036168
name: filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature." [GOC:di, PMID:17554048]
is_a: GO:0009408 ! response to heat
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:0036169
name: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2." [GOC:mw, PMID:620805, PMID:7028108]
xref: Reactome:R-HSA-2162195 "COQ4 decarboxylates MHDB"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0036170
name: filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment." [GOC:di, PMID:17554048]
is_a: GO:0042594 ! response to starvation
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:0036171
name: filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus." [GOC:di, PMID:17554048]
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0036172
name: thiamine salvage
namespace: biological_process
def: "A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis." [PMID:15150256, PMID:16952958]
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0009228 ! thiamine biosynthetic process

[Term]
id: GO:0036173
name: thiosulfate binding
namespace: molecular_function
def: "Binding to a thiosulfate, a sulfur oxide that has formula O3S2." [GOC:db, PMID:2188959]
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0036174
name: butane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O." [GOC:dh, PMID:17526838, PMID:19383682]
synonym: "sBMO" RELATED [PMID:19383682]
synonym: "soluble butane monooxygenase" RELATED [PMID:19383682]
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036175
name: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin." [GOC:bf, GOC:pde, PMID:19176520, PMID:31266802, PMID:7476363]
xref: Reactome:R-HSA-111742 "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)"
xref: Reactome:R-HSA-8866405 "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)"
is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0036176
name: response to neutral pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, Wikipedia:PH]
is_a: GO:0009268 ! response to pH

[Term]
id: GO:0036177
name: filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, Wikipedia:PH]
is_a: GO:0009268 ! response to pH
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:0036178
name: filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus." [GOC:di, PMID:6374461]
is_a: GO:0036176 ! response to neutral pH
is_a: GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH

[Term]
id: GO:0036179
name: osteoclast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg]
synonym: "chondroclast maturation" RELATED [CL:0000092]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0036035 ! osteoclast development

[Term]
id: GO:0036180
name: filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus." [GOC:di]
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:0036181
name: protein localization to linear element
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase." [GOC:mah, PMID:19756689]
synonym: "protein localisation to linear element" EXACT [GOC:mah]
is_a: GO:1903084 ! protein localization to condensed nuclear chromosome

[Term]
id: GO:0036182
name: asperthecin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di]
synonym: "asperthecin metabolism" EXACT [GOC:bf]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0036183
name: asperthecin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di]
synonym: "asperthecin breakdown" EXACT [GOC:bf]
synonym: "asperthecin catabolism" EXACT [GOC:bf]
synonym: "asperthecin degradation" EXACT [GOC:bf]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0036182 ! asperthecin metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0036184
name: asperthecin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di]
synonym: "asperthecin biosynthesis" EXACT [GOC:bf]
synonym: "asperthecin formation" EXACT [GOC:bf]
synonym: "asperthecin synthesis" EXACT [GOC:bf]
is_a: GO:0036182 ! asperthecin metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0036185
name: 13-lipoxin reductase activity
namespace: molecular_function
def: "Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+." [GOC:mw, PMID:10837478]
xref: Reactome:R-HSA-2161844 "15k-LXA4 is reduced to dhk-LXA4 by PTGR1"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036186
name: early phagosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an early phagosome." [GOC:phg]
synonym: "early phagocytic vesicle membrane" EXACT [GOC:bf]
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0032009 ! early phagosome

[Term]
id: GO:0036187
name: cell growth mode switching, budding to filamentous
namespace: biological_process
def: "The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans." [GOC:di]
synonym: "yeast to hyphal transition" RELATED [GOC:di]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0036188
name: abieta-7,13-dien-18-al dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+." [EC:1.2.1.74]
synonym: "abietadienal dehydrogenase" BROAD [EC:1.2.1.74]
xref: EC:1.2.1.74
xref: KEGG_REACTION:R06357
xref: MetaCyc:RXN-10624
xref: RHEA:26225
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036189
name: abieta-7,13-diene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O." [EC:1.14.14.144]
synonym: "abietadiene hydroxylase" BROAD [EC:1.14.14.144]
xref: EC:1.14.14.144
xref: KEGG_REACTION:R06351
xref: MetaCyc:RXN-8507
xref: RHEA:26217
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036190
name: indole-2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]." [RHEA:31899]
xref: EC:1.14.14.153
xref: KEGG_REACTION:R07403
xref: RHEA:31899
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036191
name: indolin-2-one monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O." [EC:1.14.14.157, RHEA:31919]
synonym: "indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.14.157]
xref: EC:1.14.14.157
xref: KEGG_REACTION:R07421
xref: RHEA:31919
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036192
name: 3-hydroxyindolin-2-one monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:31927]
synonym: "3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)" RELATED [EC:1.14.14.109]
xref: EC:1.14.14.109
xref: KEGG_REACTION:R07422
xref: RHEA:31927
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036193
name: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:31939]
xref: EC:1.14.14.110
xref: KEGG_REACTION:R07423
xref: RHEA:31939
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036194
name: muscle cell projection
namespace: cellular_component
def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
synonym: "muscle arm" NARROW [GOC:kmv]
synonym: "myocyte projection" EXACT [CL:0000187]
synonym: "myopodia" NARROW [GOC:kmv]
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0036195
name: muscle cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0036194 ! muscle cell projection

[Term]
id: GO:0036196
name: zymosterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [GOC:yaf]
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0036197
name: zymosterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [GOC:yaf, MetaCyc:PWY-6074]
synonym: "zymosterol anabolism" EXACT [GOC:bf]
synonym: "zymosterol biosynthesis" EXACT [GOC:bf]
synonym: "zymosterol formation" EXACT [GOC:bf]
synonym: "zymosterol synthesis" EXACT [GOC:bf]
xref: MetaCyc:PWY-6074
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0036196 ! zymosterol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0036198
name: dTMP salvage
namespace: biological_process
def: "Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis." [GOC:yaf, PMID:5387459]
synonym: "deoxythymidine monophosphate biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459]
synonym: "dTMP biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459]
is_a: GO:0006231 ! dTMP biosynthetic process
is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage

[Term]
id: GO:0036199
name: cholest-4-en-3-one 26-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate." [EC:1.14.15.29]
xref: EC:1.14.15.29
xref: KEGG_REACTION:R09859
xref: RHEA:51564
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036200
name: 3-ketosteroid 9-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [EC:1.14.15.30]
synonym: "3-ketosteroid 9alpha-hydroxylase activity" RELATED [EC:1.14.15.30]
synonym: "KshAB activity" RELATED [EC:1.14.15.30]
xref: EC:1.14.15.30
xref: KEGG_REACTION:R09860
xref: RHEA:32199
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036201
name: ent-isokaurene C2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+." [EC:1.14.14.76]
xref: EC:1.14.14.76
xref: KEGG_REACTION:R09861
xref: RHEA:56336
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036202
name: ent-cassa-12,15-diene 11-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O." [EC:1.14.14.112]
synonym: "ent-cassadiene C11alpha-hydroxylase activity" RELATED [EC:1.14.14.112]
xref: EC:1.14.14.112
xref: KEGG_REACTION:R09866
xref: RHEA:31967
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036203
name: taxoid 14-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O." [EC:1.14.13.146]
xref: EC:1.14.13.146
xref: KEGG_REACTION:R09867
xref: RHEA:31971
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036204
name: abieta-7,13-dien-18-ol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O." [EC:1.14.14.145]
xref: EC:1.14.14.145
xref: KEGG_REACTION:R06354
xref: MetaCyc:RXN-12799
xref: RHEA:26221
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036205
name: histone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells." [GOC:krc]
comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells.
synonym: "histone protein catabolic process" EXACT [GOC:bf, GOC:jl]
is_a: GO:0030163 ! protein catabolic process

[Term]
id: GO:0036206
name: obsolete regulation of histone gene expression
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]
comment: This term was obsoleted because it refers to a specific gene product. The gene product should be captured as an annotation extension using 'has input'.
synonym: "regulation of expression of histone-encoding gene" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0036207
name: obsolete positive regulation of histone gene expression
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]
comment: This term was obsoleted because it refers to a specific gene product. The gene product should be captured as an annotation extension using 'has input'.
synonym: "activation of histone gene expression" NARROW [GOC:bf]
synonym: "positive regulation of expression of histone-encoding gene" EXACT [GOC:bf]
synonym: "up-regulation of histone gene expression" EXACT [GOC:bf]
synonym: "upregulation of histone gene expression" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0036208
name: obsolete negative regulation of histone gene expression
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]
comment: This term was obsoleted because the gene product should be captured as an annotation extension using 'has input'.
synonym: "down-regulation of histone gene expression" EXACT [GOC:bf]
synonym: "downregulation of histone gene expression" EXACT [GOC:bf]
synonym: "inhibition of histone gene expression" NARROW [GOC:bf]
synonym: "negative regulation of expression of histone-encoding gene" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:0036209
name: 9beta-pimara-7,15-diene oxidase activity
namespace: molecular_function
alt_id: GO:0102609
def: "Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]." [RHEA:31951]
synonym: "9-beta-stemod-13(17)-ene oxidase activity" RELATED []
xref: EC:1.14.14.111
xref: KEGG_REACTION:R09865
xref: MetaCyc:RXN-15437
xref: RHEA:31951
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036210
name: obsolete protein modification process in another organism
namespace: biological_process
def: "OBSOLETE. The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]
comment: This term was obsoleted because it represents a readout.
synonym: "protein modification in other organism" EXACT [GOC:bf]
synonym: "protein modification process in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0036211
name: protein modification process
namespace: biological_process
alt_id: GO:0006464
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
synonym: "cellular protein modification process" EXACT []
synonym: "process resulting in protein modification" EXACT []
synonym: "protein modification" EXACT [GOC:bf]
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0036212
name: obsolete contractile ring maintenance
namespace: biological_process
def: "OBSOLETE. The process in which the contractile ring is maintained, typically in response to an internal or external cue." [GOC:mah, GOC:vw]
comment: The reason for obsoletion is that this represents a phenotype.
is_obsolete: true

[Term]
id: GO:0036213
name: contractile ring contraction
namespace: biological_process
def: "The process of an actomyosin ring getting smaller in diameter." [GOC:mah, GOC:vw]
comment: This term can be used to annotate contraction of either bacterial or fungal contractile rings.
synonym: "contractile ring constriction" EXACT [GOC:vw]
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0036214
name: obsolete contractile ring localization
namespace: biological_process
def: "OBSOLETE. The process in which a contractile ring is positioned or maintained in a specific location." [GOC:mah, GOC:vw]
comment: This term was an unnecessary grpuping term.
is_obsolete: true
replaced_by: GO:0007105

[Term]
id: GO:0036215
name: response to stem cell factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh]
synonym: "response to hematopoietic growth factor KL" EXACT [PR:000009345]
synonym: "response to KIT ligand" EXACT [PR:000009345]
synonym: "response to SCF" EXACT [PR:000009345]
synonym: "response to stem cell factor stimulus" EXACT [GOC:dos]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0036216
name: cellular response to stem cell factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444]
synonym: "cellular response to hematopoietic growth factor KL" EXACT [PR:000009345]
synonym: "cellular response to KIT ligand" EXACT [PR:000009345]
synonym: "cellular response to KITLG" EXACT [PMID:18787413]
synonym: "cellular response to SCF" EXACT [PR:000009345]
is_a: GO:0036215 ! response to stem cell factor
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0036217
name: dGTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate." [GOC:dgf, PMID:17090528, PMID:22531138, RHEA:28362]
synonym: "2'-deoxyguanosine 5'-triphosphate diphosphohydrolase" EXACT [KEGG_REACTION:R01855]
synonym: "dGTP pyrophosphatase activity" EXACT []
xref: KEGG_REACTION:R01855
xref: RHEA:28362
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0036218
name: dTTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate." [GOC:dgf, PMID:22531138, RHEA:28534]
synonym: "dTTP pyrophosphatase activity" EXACT []
xref: MetaCyc:RXN0-5107
xref: RHEA:28534
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0036219
name: GTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate." [GOC:dgf, PMID:22531138, RHEA:29391]
synonym: "GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase" EXACT [KEGG_REACTION:R00426]
synonym: "GTP diphosphohydrolase activity" EXACT [GOC:bf]
synonym: "GTP pyrophosphatase activity" EXACT []
xref: KEGG_REACTION:R00426
xref: RHEA:29391
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0036220
name: ITP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ITP + H2O = IMP + H+ + diphosphate." [GOC:dgf, PMID:17899088, PMID:22531138, RHEA:29399]
synonym: "inosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R00720]
synonym: "ITP pyrophosphatase activity" EXACT []
xref: EC:3.6.1.66
xref: KEGG_REACTION:R00720
xref: MetaCyc:RXN0-6382
xref: Reactome:R-HSA-2509827 "ITPA hydrolyses ITP to IMP"
xref: RHEA:29399
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0036221
name: UTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate." [GOC:dgf, PMID:17899088, RHEA:29395]
synonym: "uridine triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R00662]
xref: KEGG_REACTION:R00662
xref: RHEA:29395
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0036222
name: XTP diphosphatase activity
namespace: molecular_function
alt_id: GO:0103024
def: "Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate." [GOC:pz, PMID:16216582, PMID:22531138, RHEA:28610]
comment: While XTP is not produced by cells, deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP, XTP, and dXTP. XTPase contributes to the removal of these abnormal bases from the cellular pool of nucleotide triphosphates.
synonym: "hypoxanthine/xanthine dNTP pyrophosphatase" RELATED [EC:3.6.1.66]
synonym: "XTP pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R02720]
synonym: "XTP/dITP diphosphatase" RELATED [EC:3.6.1.66]
synonym: "XTPase activity" EXACT []
xref: KEGG_REACTION:R02720
xref: MetaCyc:RXN0-1603
xref: Reactome:R-HSA-2509831 "ITPA hydrolyses XTP to XMP"
xref: RHEA:28610
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0036223
name: cellular response to adenine starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine." [GOC:ai]
synonym: "cellular response to adenine deprivation" EXACT [GOC:bf]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0036224
name: pairing center
namespace: cellular_component
def: "A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment." [GOC:kmv, PMID:18597662]
synonym: "homolog recognition region" EXACT [GOC:kmv]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0036225
name: cellular response to vitamin B1 starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine)." [GOC:al, Wikipedia:Thiamine]
synonym: "cellular response to thiamin starvation" EXACT []
synonym: "cellular response to vitamin B1 deprivation" EXACT [GOC:bf]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0036226
name: obsolete mitotic cell cycle arrest in response to glucose starvation
namespace: biological_process
def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose." [GOC:al, GOC:mah, PMID:958201]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G2 cell cycle arrest in response to glucose starvation' has been observed.
synonym: "cell cycle arrest in response to glucose starvation" BROAD []
is_obsolete: true

[Term]
id: GO:0036227
name: mitotic G2 cell cycle arrest in response to glucose starvation
namespace: biological_process
def: "The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose." [GOC:al, GOC:mah, GOC:mtg_cell_cycle, PMID:958201]
is_a: GO:0051726 ! regulation of cell cycle

[Term]
id: GO:0036228
name: protein localization to nuclear inner membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane." [GOC:dgf, PMID:16929305]
synonym: "protein targeting to INM" RELATED [PMID:16929305]
synonym: "protein targeting to nuclear inner membrane" RELATED []
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0090435 ! protein localization to nuclear envelope

[Term]
id: GO:0036230
name: granulocyte activation
namespace: biological_process
def: "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0036234
name: deglucuronidation
namespace: biological_process
def: "The removal of glucuronic acid from a conjugated substrate." [GOC:BHF, GOC:vk, PMID:22294686, PMID:8560473]
is_a: GO:0019585 ! glucuronate metabolic process

[Term]
id: GO:0036235
name: acyl deglucuronidation
namespace: biological_process
def: "The removal of glucuronic acid from an acyl-glucuronide." [GOC:BHF, GOC:vk, PMID:22294686]
is_a: GO:0036234 ! deglucuronidation

[Term]
id: GO:0036236
name: acyl glucuronidation
namespace: biological_process
def: "The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside)." [GOC:BHF, GOC:vk, PMID:12485951, PMID:22294686]
is_a: GO:0052695 ! cellular glucuronidation

[Term]
id: GO:0036237
name: acyl-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate." [GOC:BHF, GOC:vk, PMID:22294686]
synonym: "acyl-glucuronide deglucuronidation activity" NARROW [PMID:22294686]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0036238
name: gallate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate." [EC:1.13.11.57, PMID:16030014]
xref: EC:1.13.11.57
xref: KEGG_REACTION:R09565
xref: MetaCyc:GALLATE-DIOXYGENASE-RXN
xref: RHEA:28927
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0036239
name: taxoid 7beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O. Also converts 2alpha-hydroxytaxusin to 2alpha,7beta-dihydroxytaxusin." [EC:1.14.14.182, PMID:15157877, PMID:15178487]
xref: EC:1.14.14.182
xref: KEGG_REACTION:R09868
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036240
name: septal periplasm
namespace: cellular_component
def: "The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi." [GOC:di, PMID:21564341]
synonym: "cell wall-enclosed septal periplasm" EXACT [GOC:di]
is_a: GO:0042597 ! periplasmic space

[Term]
id: GO:0036241
name: glutamate catabolic process to 4-hydroxybutyrate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate." [GOC:bf, MetaCyc:PWY-4321]
comment: In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase.
synonym: "glutamate degradation to 4-hydroxybutyrate" EXACT [MetaCyc:PWY-4321]
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0036242
name: obsolete glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf]
comment: The reason for obsoletion is that this term was added in error (unnecessary specificity, these are steps in a single pathway)
is_obsolete: true
replaced_by: GO:0006540

[Term]
id: GO:0036243
name: succinate-semialdehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [GOC:bf, RHEA:13213]
comment: This function is similar to EC:1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC:1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+.
synonym: "NADP-dependent succinate-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.79]
synonym: "succinate semialdehyde:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.79]
synonym: "succinic semialdehyde dehydrogenase (NADP+) activity" RELATED [EC:1.2.1.79]
synonym: "succinyl semialdehyde dehydrogenase (NADP+) activity" RELATED [EC:1.2.1.79]
xref: EC:1.2.1.79
xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN
xref: RHEA:13213
is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0036244
name: cellular response to neutral pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, Wikipedia:PH]
is_a: GO:0036176 ! response to neutral pH
is_a: GO:0071467 ! cellular response to pH

[Term]
id: GO:0036245
name: cellular response to menadione
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al, Wikipedia:Menadione]
synonym: "cellular response to vitamin K3" EXACT [GOC:al]
is_a: GO:0071307 ! cellular response to vitamin K

[Term]
id: GO:0036246
name: phytochelatin 2 import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374]
synonym: "PC2 import into vacuole" EXACT [GOC:al]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0071995 ! phytochelatin import into vacuole

[Term]
id: GO:0036247
name: phytochelatin 3 import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374]
synonym: "PC3 import into vacuole" EXACT [GOC:al]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0071995 ! phytochelatin import into vacuole

[Term]
id: GO:0036248
name: phytochelatin 4 import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374]
synonym: "PC4 import into vacuole" EXACT [GOC:al]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0071995 ! phytochelatin import into vacuole

[Term]
id: GO:0036249
name: cadmium ion import into vacuole
namespace: biological_process
def: "The directed movement of cadmium ions into the vacuole." [GOC:al]
synonym: "vacuolar cadmium import" RELATED [GOC:bf]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0070574 ! cadmium ion transmembrane transport

[Term]
id: GO:0036250
name: peroxisome transport along microtubule
namespace: biological_process
def: "The directed movement of a peroxisome along a microtubule, mediated by motor proteins." [GOC:pm, PMID:21525035]
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0036251
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:0071472

[Term]
id: GO:0036252
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to menadione
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to menadione stress" NARROW [GOC:al]
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:0036253
name: obsolete response to amiloride
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:0036254
name: obsolete cellular response to amiloride
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:0036255
name: response to methylamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah]
is_a: GO:0014075 ! response to amine

[Term]
id: GO:0036256
name: cellular response to methylamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah]
is_a: GO:0036255 ! response to methylamine
is_a: GO:0071418 ! cellular response to amine stimulus

[Term]
id: GO:0036257
name: multivesicular body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881]
synonym: "MVB organization" EXACT [GOC:bf]
is_a: GO:0007032 ! endosome organization

[Term]
id: GO:0036258
name: multivesicular body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881, PMID:19571114]
synonym: "multivesicular body biogenesis" EXACT [PMID:19571114]
synonym: "MVB biogenesis" EXACT [PMID:19571114]
synonym: "MVB formation" EXACT [PMID:19571114]
is_a: GO:0036257 ! multivesicular body organization
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0036259
name: aerobic raffinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen." [GOC:al, PMID:10082789]
synonym: "aerobic raffinose breakdown" EXACT [GOC:bf]
synonym: "aerobic raffinose catabolism" EXACT [GOC:bf]
synonym: "aerobic raffinose degradation" EXACT [GOC:bf]
is_a: GO:0034484 ! raffinose catabolic process

[Term]
id: GO:0036260
name: RNA capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673]
is_a: GO:0000966 ! RNA 5'-end processing

[Term]
id: GO:0036261
name: 7-methylguanosine cap hypermethylation
namespace: biological_process
def: "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984]
synonym: "2,2,7-trimethylguanosine cap formation" EXACT [PMID:11983179]
synonym: "conversion of m(7)G to m(3)G" EXACT [PMID:11983179]
synonym: "hypermethylation of snoRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah]
synonym: "hypermethylation of snRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah]
synonym: "m(7)G cap hypermethylation" EXACT [GOC:bf]
synonym: "snoRNA capping" NARROW [GOC:rl]
synonym: "snRNA capping" NARROW [GOC:rl]
synonym: "TMG cap formation" EXACT [PMID:11983179]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0036260 ! RNA capping

[Term]
id: GO:0036262
name: granulysin production
namespace: biological_process
def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0036265
name: RNA (guanine-N7)-methylation
namespace: biological_process
def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule." [GOC:BHF, GOC:rl]
is_a: GO:0001510 ! RNA methylation

[Term]
id: GO:0036266
name: Cdc48p-Npl4p-Vms1p AAA ATPase complex
namespace: cellular_component
def: "A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p." [GOC:rn, PMID:21070972, PMID:21936843]
synonym: "Cdc48p-Npl4p-Vms1p complex" EXACT [GOC:rn]
synonym: "Vms1-Cdc48-Npl4 complex" EXACT [GOC:rn]
synonym: "Vms1p-Cdc48p-Npl4p complex" EXACT [GOC:rn]
is_a: GO:0098799 ! outer mitochondrial membrane protein complex

[Term]
id: GO:0036267
name: invasive filamentous growth
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells into a substrate." [GOC:di, PMID:22276126]
synonym: "invasive growth" EXACT [GOC:di]
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0036268
name: swimming
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through water, often by means of active fin movement." [GOC:cvs, PMID:22459995]
comment: For behavioral aspects of swimming, consider instead annotating to 'swimming behavior ; GO:0036269'.
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0036269
name: swimming behavior
namespace: biological_process
def: "The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water." [GOC:cvs, PMID:16764679]
synonym: "swimming behaviour" EXACT [PMID:16764679]
is_a: GO:0007626 ! locomotory behavior

[Term]
id: GO:0036270
name: response to diuretic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0036271
name: response to methylphenidate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus." [GOC:hp, Wikipedia:Methylphenidate]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to MPD" EXACT [CHEBI:6887]
synonym: "response to MPH" EXACT [CHEBI:6887]
synonym: "response to ritalin" EXACT [CHEBI:6887]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0036272
name: response to gemcitabine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas." [GOC:hp, Wikipedia:Gemcitabine]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901]
synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0036273
name: response to statin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664]
synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0036274
name: response to lapatinib
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0036275
name: response to 5-fluorouracil
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345]
synonym: "response to fluorouracil" EXACT [GOC:hp]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0036276
name: response to antidepressant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0036277
name: response to anticonvulsant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0036278
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen." [GOC:al, PMID:21118960]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006995
consider: GO:0045944

[Term]
id: GO:0036279
name: positive regulation of protein export from nucleus in response to glucose starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose." [GOC:al, PMID:3541942]
is_a: GO:0042149 ! cellular response to glucose starvation
is_a: GO:0046827 ! positive regulation of protein export from nucleus

[Term]
id: GO:0036280
name: cellular response to L-canavanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group." [GOC:al]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901354 ! response to L-canavanine
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0036283
name: obsolete positive regulation of transcription factor import into nucleus in response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus under conditions of oxidative stress." [GOC:al, PMID:9585505]
comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
synonym: "positive regulation of transcription factor import into nucleus in response to hydrogen peroxide" RELATED [GOC:al]
is_obsolete: true
consider: GO:0034599
consider: GO:0042307

[Term]
id: GO:0036284
name: tubulobulbar complex
namespace: cellular_component
def: "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes." [GOC:sl, PMID:22510523]
synonym: "TBC" EXACT [GOC:sl, PMID:22510523]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0036285
name: SAGA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof." [GOC:mah, PMID:10637607, PMID:22456315]
synonym: "SAGA complex formation" EXACT [GOC:bf]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0036286
name: eisosome filament
namespace: cellular_component
def: "A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:vw, PMID:21900489, PMID:23722945]
synonym: "linear eisosome" EXACT [GOC:vw]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030863 ! cortical cytoskeleton
relationship: part_of GO:0032126 ! eisosome

[Term]
id: GO:0036287
name: response to iloperidone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0036288
name: response to ximelagatran
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0036289
name: peptidyl-serine autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein." [GOC:pm]
subset: gocheck_obsoletion_candidate
synonym: "serine autophosphorylation" EXACT [GOC:bf]
is_a: GO:0018105 ! peptidyl-serine phosphorylation
is_a: GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0036290
name: protein trans-autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:jsg, PMID:20516151]
subset: gocheck_obsoletion_candidate
synonym: "trans-autophosphorylation" EXACT [GOC:jsg]
is_a: GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0036291
name: obsolete protein cis-autophosphorylation
namespace: biological_process
def: "OBSOLETE. The phosphorylation by a protein of one or more of its own amino acid residues." [GOC:jsg, PMID:9201908]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cis-autophosphorylation" EXACT [GOC:jsg]
is_obsolete: true

[Term]
id: GO:0036292
name: DNA rewinding
namespace: biological_process
def: "The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634]
synonym: "DNA annealing" RELATED [GOC:sp]
synonym: "RPA-dependent DNA rewinding" NARROW [PMID:21078962]
synonym: "single-stranded DNA bubble rewinding" NARROW [PMID:18974355]
is_a: GO:0032392 ! DNA geometric change

[Term]
id: GO:0036293
name: response to decreased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]
comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'.
synonym: "response to lowered oxygen levels" EXACT [GOC:bf]
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0036294
name: cellular response to decreased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]
comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'cellular response to hypoxia ; GO:0071456'.
synonym: "cellular response to lowered oxygen levels" EXACT [GOC:bf]
is_a: GO:0036293 ! response to decreased oxygen levels
is_a: GO:0071453 ! cellular response to oxygen levels

[Term]
id: GO:0036295
name: cellular response to increased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]
comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'cellular response to hyperoxia ; GO:0071455'.
synonym: "cellular response to raised oxygen levels" EXACT [GOC:bf]
is_a: GO:0036296 ! response to increased oxygen levels
is_a: GO:0071453 ! cellular response to oxygen levels

[Term]
id: GO:0036296
name: response to increased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]
comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'response to hyperoxia ; GO:0055093.
synonym: "response to raised oxygen levels" EXACT [GOC:bf]
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0036297
name: interstrand cross-link repair
namespace: biological_process
def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]
synonym: "ICL repair" EXACT [PMID:20658649]
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0036298
name: recombinational interstrand cross-link repair
namespace: biological_process
def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:vw, PMID:20658649]
synonym: "Fanconi pathway" RELATED [PMID:31563844]
synonym: "recombination-dependent interstrand cross-link repair" EXACT [GOC:vw]
is_a: GO:0000725 ! recombinational repair
is_a: GO:0036297 ! interstrand cross-link repair

[Term]
id: GO:0036299
name: non-recombinational interstrand cross-link repair
namespace: biological_process
def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination." [GOC:vw, PMID:11154259, PMID:22064477]
synonym: "recombination-independent ICL repair" EXACT [GOC:vw]
synonym: "recombination-independent interstrand cross-link repair" EXACT [GOC:vw]
is_a: GO:0036297 ! interstrand cross-link repair

[Term]
id: GO:0036300
name: B cell receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell." [GOC:add, GOC:amm]
synonym: "B cell receptor uptake of antigen" NARROW [PMID:10996020]
synonym: "BCR endocytosis" EXACT [GOC:bf]
synonym: "BCR receptor internalization" EXACT [GOC:amm]
is_a: GO:0031623 ! receptor internalization

[Term]
id: GO:0036301
name: macrophage colony-stimulating factor production
namespace: biological_process
def: "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:vk]
subset: gocheck_do_not_annotate
synonym: "M-CSF production" EXACT [GOC:vk]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0036302
name: atrioventricular canal development
namespace: biological_process
def: "The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle." [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0036303
name: lymph vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph." [GOC:BHF, GOC:gr, PMID:18093989]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0001945 ! lymph vessel development

[Term]
id: GO:0036304
name: umbilical cord morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:gr, PMID:15107403]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0061027 ! umbilical cord development

[Term]
id: GO:0036305
name: ameloblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ." [CL:0000059]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0036306
name: embryonic heart tube elongation
namespace: biological_process
def: "The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:BHF, GOC:gr, PMID:15901664]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0036307
name: 23S rRNA (adenine(2030)-N(6))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA." [GOC:imk, PMID:22847818, RHEA:43736]
xref: EC:2.1.1.266
xref: RHEA:43736
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity

[Term]
id: GO:0036308
name: 16S rRNA (guanine(1516)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine." [GOC:imk, PMID:22079366]
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0036309
name: protein localization to M-band
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere." [GOC:BHF, GOC:rl, PMID:18782775]
synonym: "cellular protein localization to M-band" EXACT [GOC:rl]
synonym: "protein localization to M disc" EXACT [GOC:rl]
synonym: "protein localization to M line" NARROW [GOC:rl]
synonym: "protein localization to mesophragma" EXACT [GOC:rl]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0036310
name: ATP-dependent DNA/DNA annealing activity
namespace: molecular_function
def: "An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634, PMID:22888405]
synonym: "annealing helicase activity" RELATED [PMID:22888405]
synonym: "ATP-dependent DNA annealing activity" RELATED [GOC:sp]
synonym: "DNA rewinding activity" RELATED [PMID:22888405]
synonym: "nucleoside-triphosphatase activity involved in DNA annealing" EXACT [GOC:bf]
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA
is_a: GO:1990814 ! DNA/DNA annealing activity

[Term]
id: GO:0036311
name: chitin disaccharide deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine." [RHEA:27469]
comment: In contrast to EC:3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide.
synonym: "chitin oligosaccharide amidohydrolase activity" RELATED [EC:3.5.1.105]
synonym: "chitin oligosaccharide deacetylase activity" RELATED [EC:3.5.1.105]
synonym: "chitobiose amidohydrolase activity" RELATED [EC:3.5.1.105]
xref: EC:3.5.1.105
xref: MetaCyc:RXN-11313
xref: RHEA:27469
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0036312
name: phosphatidylinositol 3-kinase regulatory subunit binding
namespace: molecular_function
def: "Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location." [GOC:bf, PMID:20505341]
synonym: "p85 binding" RELATED [PMID:10627473, PMID:20505341]
synonym: "PI3K regulatory subunit binding" EXACT [GOC:bf]
is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding

[Term]
id: GO:0036313
name: phosphatidylinositol 3-kinase catalytic subunit binding
namespace: molecular_function
def: "Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214]
synonym: "p110 binding" RELATED [PMID:17475214]
synonym: "PI3K catalytic subunit binding" EXACT [GOC:bf]
is_a: GO:0019900 ! kinase binding
is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding

[Term]
id: GO:0036314
name: response to sterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [GOC:bf]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0036315
name: cellular response to sterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [GOC:bf]
is_a: GO:0036314 ! response to sterol
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0036316
name: SREBP-SCAP complex retention in endoplasmic reticulum
namespace: biological_process
def: "Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER." [GOC:bf, PMID:16525117]
comment: Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937.
is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
relationship: part_of GO:0036315 ! cellular response to sterol

[Term]
id: GO:0036317
name: tyrosyl-RNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis." [GOC:bf, GOC:sp, PMID:21408223, PMID:22908287]
synonym: "unlinkase activity" EXACT [PMID:21408223]
synonym: "uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity" EXACT [PMID:21408223]
synonym: "VPg unlinkase activity" EXACT [GOC:sp, PMID:21408223, PMID:22908287]
synonym: "Y-pUpN PDE activity" EXACT [PMID:21408223]
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0036318
name: peptide pheromone receptor activity
namespace: molecular_function
def: "Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:al]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity
is_a: GO:0016503 ! pheromone receptor activity

[Term]
id: GO:0036319
name: mating-type M-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus." [GOC:al, PMID:7941744]
synonym: "M-factor mating pheromone receptor activity" EXACT []
synonym: "M-factor receptor activity" EXACT []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity

[Term]
id: GO:0036320
name: mating-type P-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [GOC:al, PMID:8314086]
synonym: "P-factor mating pheromone receptor activity" EXACT []
synonym: "P-factor receptor activity" EXACT []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity

[Term]
id: GO:0036321
name: ghrelin secretion
namespace: biological_process
def: "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin]
synonym: "pancreatic ghrelin secretion" NARROW [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0036322
name: pancreatic polypeptide secretion
namespace: biological_process
def: "The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas." [GOC:cjm, PMID:12730894, Wikipedia:Pancreatic_polypeptide]
synonym: "PP secretion" NARROW [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0036323
name: vascular endothelial growth factor receptor-1 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:FLT1, Wikipedia:VEGF_receptors]
synonym: "FLT1 signaling pathway" EXACT [GOC:uh, PR:000007563]
synonym: "VEGFR-1 signaling pathway" EXACT [PR:000007563, Wikipedia:VEGF_receptors]
synonym: "VEGFR1 signaling pathway" EXACT []
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0036324
name: vascular endothelial growth factor receptor-2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]
synonym: "FLK-1 signaling pathway" EXACT [PR:000002112]
synonym: "KDR signaling pathway" EXACT [GOC:uh, PR:000002112, Wikipedia:Kinase_insert_domain_receptor]
synonym: "VEGFR-2 signaling pathway" EXACT [PR:000002112, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]
synonym: "VEGFR2 signaling pathway" EXACT []
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0036325
name: vascular endothelial growth factor receptor-3 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-3 (VEGFR-3) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3]
synonym: "FLT4 signaling pathway" EXACT [GOC:uh, PR:000007565]
synonym: "VEGFR-3 signaling pathway" EXACT [Wikipedia:VEGF_receptors]
synonym: "VEGFR3 signaling pathway" EXACT [Wikipedia:VEGFR3]
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0036331
name: avascular cornea development in camera-type eye
namespace: biological_process
def: "The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees." [GOC:uh, PMID:16849433, PMID:17051153]
synonym: "avascular cornea development" EXACT [GOC:bf]
is_a: GO:0061303 ! cornea development in camera-type eye

[Term]
id: GO:0036332
name: placental growth factor receptor activity
namespace: molecular_function
def: "Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, Wikipedia:Placental_growth_factor]
synonym: "placental growth factor-activated receptor activity" EXACT []
synonym: "PlGF receptor activity" RELATED [PMID:12871269]
synonym: "PlGF-activated receptor activity" EXACT [GOC:uh, PMID:12871269]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0036333
name: hepatocyte homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874]
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0036334
name: epidermal stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529]
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0036335
name: intestinal stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863, PMID:22608824]
synonym: "intestinal crypt stem cell homeostasis" NARROW []
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0036336
name: dendritic cell migration
namespace: biological_process
def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990]
is_a: GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0036337
name: Fas signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily." [GOC:nhn, PMID:12040174, Wikipedia:Fas_receptor]
synonym: "Apo-1 signaling pathway" EXACT [PMID:12040174]
synonym: "CD95 signaling pathway" EXACT [PMID:12040174]
synonym: "FAS ligand-Fas signaling pathway" NARROW [PMID:12040174]
synonym: "Fas receptor signaling pathway" EXACT [Wikipedia:Fas_receptor]
synonym: "Fas-FasL signaling pathway" NARROW [GOC:bf]
synonym: "FasL signaling pathway" RELATED [Wikipedia:Fas_ligand]
synonym: "FasR signaling pathway" EXACT [Wikipedia:Fas_receptor]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0036338
name: viral membrane
namespace: cellular_component
def: "The lipid bilayer of a virion, a complete fully infectious extracellular virus particle." [GOC:bm]
is_a: GO:0044423 ! virion component

[Term]
id: GO:0036339
name: lymphocyte adhesion to endothelial cell of high endothelial venule
namespace: biological_process
def: "The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [CL:0000542, CL:0002652, GOC:nhn, PMID:19339990, PMID:7679710, Wikipedia:High_endothelial_venules]
comment: For the transition of leukocytes from rolling to adhered, consider instead annotating to 'leukocyte adhesive activation ; GO:0050902'.
synonym: "lymphocyte adhesion to HEV cell" EXACT [PMID:7679710, Wikipedia:High_endothelial_venules]
synonym: "lymphocyte adhesion to high endothelial venule" EXACT [GOC:nhn]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell

[Term]
id: GO:0036340
name: chitin-based cuticle sclerotization by biomineralization
namespace: biological_process
def: "The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate." [GOC:sart]
synonym: "chitin-based cuticle hardening by biomineralisation" EXACT [GOC:bf]
is_a: GO:0007593 ! chitin-based cuticle sclerotization
is_a: GO:0031214 ! biomineral tissue development

[Term]
id: GO:0036341
name: chitin-based cuticle sclerotization by protein cross-linking
namespace: biological_process
def: "The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle." [GOC:bf, GOC:sart]
synonym: "chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning" NARROW [GOC:bf, GOC:dos, GOC:sart]
is_a: GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0036342
name: post-anal tail morphogenesis
namespace: biological_process
def: "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0036343
name: psychomotor behavior
namespace: biological_process
def: "The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument." [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning]
is_a: GO:0061744 ! motor behavior

[Term]
id: GO:0036344
name: platelet morphogenesis
namespace: biological_process
def: "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk]
is_a: GO:0000902 ! cell morphogenesis

[Term]
id: GO:0036345
name: platelet maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk]
is_a: GO:0048469 ! cell maturation

[Term]
id: GO:0036346
name: cellular response to L-cysteine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration." [GOC:al]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901367 ! response to L-cysteine
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0036348
name: hydantoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin." [EC:5.1.99.5, InterPro:IPR015942]
xref: EC:5.1.99.5
xref: KEGG_REACTION:R09704
xref: MetaCyc:RXN-9781
xref: RHEA:46624
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0036349
name: galactose-specific flocculation
namespace: biological_process
alt_id: GO:0098611
def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:vw, PMID:22098069]
synonym: "cell-cell adhesion involved in galactose-specific flocculation" EXACT []
is_a: GO:0000128 ! flocculation

[Term]
id: GO:0036350
name: mannose-specific flocculation
namespace: biological_process
alt_id: GO:0098612
def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:vw, PMID:9851992]
synonym: "cell-cell adhesion involved in mannose-specific flocculation" EXACT []
is_a: GO:0000128 ! flocculation

[Term]
id: GO:0036351
name: obsolete histone H2A-K13 ubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A ubiquitination (H2A-K13)" EXACT [GOC:sp]
is_obsolete: true

[Term]
id: GO:0036352
name: obsolete histone H2A-K15 ubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A ubiquitination (H2A-K15)" EXACT [GOC:sp]
is_obsolete: true

[Term]
id: GO:0036353
name: obsolete histone H2A-K119 monoubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A monoubiquitination (H2A-K119)" EXACT [GOC:sp]
is_obsolete: true

[Term]
id: GO:0036354
name: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+." [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569]
xref: MetaCyc:RXN-8787
xref: RHEA:19733
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0036355
name: 2-iminoacetate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+." [EC:4.1.99.19, GOC:crds, MetaCyc:RXN-11319, PMID:17403671]
xref: EC:4.1.99.19
xref: MetaCyc:RXN-11319
xref: RHEA:26361
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0036356
name: cyclic 2,3-diphosphoglycerate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate." [GOC:crds, PMID:2226838, PMID:8320225, PMID:9811660]
comment: This reaction is the intramolecular cyclization of 2,3-diphosphoglycerate to cyclic 2,3-diphosphoglycerate and is the second step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG).
synonym: "cDPGS activity" EXACT [PMID:9811660]
synonym: "CPGS activity" EXACT [GOC:bf]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0036357
name: obsolete 2-phosphoglycerate kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP." [GOC:bf, InterPro:IPR020872, PMID:2226838, PMID:8159166]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "2PGK activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036358
name: lipoteichoic acid D-alanylation
namespace: biological_process
def: "The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA)." [GOC:crds, PMID:22750871, PMID:8682792]
synonym: "D-alanyl lipoteichoic acid formation" EXACT [PMID:8682792]
synonym: "D-alanyl LTA formation" EXACT [PMID:8682792]
synonym: "LTA D-alanylation" EXACT [PMID:22750871]
is_a: GO:0070400 ! teichoic acid D-alanylation

[Term]
id: GO:0036359
name: renal potassium excretion
namespace: biological_process
def: "The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:gap, PMID:15034090, PMID:25287933]
synonym: "renal K(+) excretion" EXACT [PMID:16014448]
synonym: "renal K+ elimination" EXACT [PMID:15034090]
synonym: "renal potassium ion excretion" EXACT [GOC:bf]
is_a: GO:0097254 ! renal tubular secretion

[Term]
id: GO:0036360
name: sorocarp stalk morphogenesis
namespace: biological_process
def: "The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [DDANAT:0000068, GOC:pf, PMID:22902739]
synonym: "fruiting body stalk morphogenesis" BROAD [DDANAT:0000068]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0031150 ! sorocarp stalk development
relationship: part_of GO:0031288 ! sorocarp morphogenesis

[Term]
id: GO:0036361
name: racemase activity, acting on amino acids and derivatives
namespace: molecular_function
def: "Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative." [GOC:crds]
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0036362
name: ascus membrane
namespace: cellular_component
def: "A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi." [GOC:mcc, GOC:vw, PMID:21900489]
is_a: GO:0016020 ! membrane

[Term]
id: GO:0036363
name: obsolete transforming growth factor beta activation
namespace: biological_process
def: "OBSOLETE. The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms." [GOC:bf, GOC:sl, PMID:12482908, PMID:9170210]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "L-TGF-beta activation" EXACT [PMID:2070685]
synonym: "latent TGF-beta activation" EXACT [PMID:2070685]
synonym: "TGF-B activation" EXACT [GOC:sl]
synonym: "TGF-beta activation" EXACT [PR:000000046]
synonym: "TGFB activation" EXACT [GOC:sl]
synonym: "TGFbeta activation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036364
name: obsolete transforming growth factor beta1 activation
namespace: biological_process
def: "OBSOLETE. The release of transforming growth factor beta1 (TGF-beta1) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "L-TGF-beta 1 activation" EXACT [PMID:2070685]
synonym: "latent-TGF-beta1 activation" EXACT [PMID:19439069]
synonym: "TGF-beta 1 activation" EXACT [PR:000000182]
synonym: "TGFB1 activation" EXACT [PR:000000182]
synonym: "TGFbeta 1 activation" EXACT [GOC:bf]
synonym: "transforming growth factor-beta1 activation" EXACT [PMID:19513812]
is_obsolete: true

[Term]
id: GO:0036365
name: obsolete transforming growth factor beta2 activation
namespace: biological_process
def: "OBSOLETE. The release of transforming growth factor beta 2 (TGF-beta2) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "TGF-beta 2 activation" EXACT [PR:000000183]
synonym: "TGFB2 activation" EXACT [PR:000000183]
synonym: "TGFbeta 2 activation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036366
name: obsolete transforming growth factor beta3 activation
namespace: biological_process
def: "OBSOLETE. The release of transforming growth factor beta 3 (TGF-beta3) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]
comment: The reason for obsoletion is that these represent molecular functions.
synonym: "TGF-beta 3 activation" EXACT [PR:000000184]
synonym: "TGFB3 activation" EXACT [PR:000000184]
synonym: "TGFbeta 3 activation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036367
name: light adaption
namespace: biological_process
def: "The ability of a photoreceptor to adjust to varying levels of light." [GOC:gap, PMID:16039565]
comment: Light adaptation is usually a combination of cell desensitization and response acceleration.
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0036368
name: cone photoresponse recovery
namespace: biological_process
def: "The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers." [GOC:gap, PMID:16039565, PMID:22802362]
synonym: "cone phototransduction termination" RELATED [GOC:bf]
synonym: "cone response recovery" EXACT [PMID:12732716]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0036369
name: obsolete transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:al, GOC:vw, PMID:22833559]
comment: The reason for obsoletion is that this does not represent a specific pathway but a class of substrates.
synonym: "proteasome-mediated transcription factor catabolism" EXACT [GOC:bf]
synonym: "sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:bf]
synonym: "transcription factor breakdown" EXACT [GOC:bf]
synonym: "transcription factor catabolism" EXACT [GOC:bf]
synonym: "transcription factor degradation" EXACT [PMID:22833559]
is_obsolete: true
replaced_by: GO:0043161

[Term]
id: GO:0036370
name: D-alanyl carrier activity
namespace: molecular_function
def: "Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG)." [GOC:crds, PMID:11222605, PMID:22750871, PMID:8682792]
synonym: "D-alanyl carrier protein" RELATED [GOC:crds, PMID:11222605]
is_a: GO:0140414 ! phosphopantetheine-dependent carrier activity

[Term]
id: GO:0036371
name: protein localization to T-tubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:BHF, GOC:rl, PMID:16292983]
synonym: "protein localisation to T-tubule" EXACT [GOC:rl]
synonym: "protein localization to T tubule" EXACT [GOC:rl]
synonym: "protein localization to transverse tubule" EXACT [GOC:rl]
is_a: GO:0072659 ! protein localization to plasma membrane

[Term]
id: GO:0036372
name: opsin transport
namespace: biological_process
def: "The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:atm, PMID:20238016, PMID:22855808]
synonym: "ciliary transport of opsin" NARROW [GOC:20238016]
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0036373
name: L-fucose mutarotase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-L-fucose = beta-L-fucose." [GOC:crds, PMID:15060078, RHEA:25580]
synonym: "alpha-L-fucose 1-epimerase activity" RELATED [EC:5.1.3.29]
synonym: "fucose 1-epimerase activity" RELATED [EC:5.1.3.29]
synonym: "type-2 mutarotase activity" RELATED [EC:5.1.3.29]
xref: EC:5.1.3.29
xref: MetaCyc:RXN0-5298
xref: RHEA:25580
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0036374
name: glutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]
synonym: "gamma-glutamyltranspeptidase activity" RELATED [EC:3.4.19.13]
synonym: "glutathionase activity" RELATED [EC:3.4.19.13]
xref: EC:3.4.19.13
xref: KEGG_REACTION:R00494
xref: MetaCyc:RXN-12618
xref: Reactome:R-HSA-1222712 "Nitrosoglutathione gets cleaved to Cys(NO)-Gly"
xref: Reactome:R-HSA-266046 "GGT1, 5 dimers hydrolyse LTC4 to LTD4"
xref: Reactome:R-HSA-5433072 "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG"
xref: Reactome:R-HSA-5602984 "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG"
xref: Reactome:R-HSA-8943279 "GGT dimers hydrolyse GSH"
xref: Reactome:R-HSA-9026757 "GGT hydrolyses MCTR1 to MCTR2"
xref: Reactome:R-HSA-9026907 "GGT hydrolyses PCTR2 to PCTR3"
xref: Reactome:R-HSA-9026912 "GGT hydrolyses PCTR1 to PCTR2"
xref: Reactome:R-HSA-9026916 "GGT hydrolyses RCTR2 to RCTR3"
xref: Reactome:R-HSA-9026927 "GGT hydrolyses RCTR1 to RCTR2"
xref: Reactome:R-HSA-9035966 "Defective GGT1 does not hydrolyse GSH"
xref: Reactome:R-HSA-9753634 "GGT dimers hydrolyse APAP-SG"
xref: RHEA:28807
is_a: GO:0008242 ! omega peptidase activity
is_a: GO:0070003 ! threonine-type peptidase activity

[Term]
id: GO:0036375
name: Kibra-Ex-Mer complex
namespace: cellular_component
def: "An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598]
synonym: "Kbr, Ex and Mer complex" EXACT [PMID:20159598]
synonym: "KEM complex" EXACT [PMID:20159598]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0036376
name: sodium ion export across plasma membrane
namespace: biological_process
alt_id: GO:0071436
alt_id: GO:0098667
def: "The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:14674689]
synonym: "sodium export" RELATED [GOC:mah]
synonym: "sodium ion export" RELATED []
synonym: "sodium ion export from cell" EXACT []
is_a: GO:0035725 ! sodium ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0036377
name: arbuscular mycorrhizal association
namespace: biological_process
def: "A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil." [GOC:sk, Wikipedia:Arbuscular_mycorrhiza]
synonym: "arbuscular mycorrhizae formation" EXACT [Wikipedia:Arbuscular_mycorrhiza]
synonym: "arbuscular mycorrhizal symbiosis" RELATED [Wikipedia:Arbuscular_mycorrhiza]
synonym: "arbuscular mycorrhizas formation" EXACT [Wikipedia:Arbuscular_mycorrhiza]
is_a: GO:0044403 ! biological process involved in symbiotic interaction

[Term]
id: GO:0036378
name: calcitriol biosynthetic process from calciol
namespace: biological_process
def: "Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol." [GOC:BHF, GOC:rl, PMID:17426122, PMID:20511049]
synonym: "1alpha,25(OH)2D3 biosynthesis" BROAD [CHEBI:17823]
synonym: "1alpha,25-dihydroxycholecalciferol biosynthesis" BROAD [CHEBI:17823]
synonym: "1alpha,25-dihydroxyvitamin D3 biosynthesis" BROAD [CHEBI:17823]
synonym: "calcitriol biosynthesis from calciol" EXACT [GOC:bf]
synonym: "vitamin D3 activation" EXACT [GOC:bf, PMID:20506379]
is_a: GO:0042368 ! vitamin D biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0070640 ! vitamin D3 metabolic process

[Term]
id: GO:0036379
name: myofilament
namespace: cellular_component
def: "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament]
synonym: "striated muscle filament" EXACT [GOC:bf]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0036380
name: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.33, GOC:rs]
synonym: "GlcNAc-P-P-Und synthase activity" RELATED [EC:2.7.8.33]
synonym: "UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity" RELATED [EC:2.7.8.33]
synonym: "UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" RELATED [EC:2.7.8.33]
synonym: "UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity" RELATED [EC:2.7.8.33]
synonym: "UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" RELATED [EC:2.7.8.33]
xref: EC:2.7.8.33
xref: KEGG_REACTION:R08856
xref: MetaCyc:GLCNACPTRANS-RXN
xref: RHEA:28090
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0036381
name: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate." [EC:4.3.3.6, GOC:rs]
synonym: "PdxST activity" RELATED [EC:4.3.3.6]
synonym: "pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity" RELATED [EC:4.3.3.6]
xref: EC:4.3.3.6
xref: KEGG_REACTION:R10089
xref: MetaCyc:RXN-11322
xref: RHEA:31507
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0036382
name: flavin reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH." [GOC:rs, RHEA:31303]
xref: EC:1.5.1.36
xref: KEGG_REACTION:R09662
xref: MetaCyc:RXN-12446
xref: RHEA:31303
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036383
name: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O." [EC:1.14.14.12, GOC:rs]
xref: EC:1.14.14.12
xref: KEGG_REACTION:R09819
xref: MetaCyc:RXN-12717
xref: RHEA:31731
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0036384
name: CDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP + H2O = CMP + phosphate." [GOC:al, RHEA:64880]
synonym: "CDP diphosphatase activity" BROAD []
synonym: "CDPase activity" EXACT [GOC:al]
synonym: "cytidine diphosphatase activity" EXACT []
synonym: "cytidine-diphosphatase activity" EXACT []
xref: RHEA:64880
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0036385
name: obsolete nucleoid DNA packaging
namespace: biological_process
def: "OBSOLETE. Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid." [GOC:bf, GOC:bhm]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0036386
name: bacterial nucleoid packaging
namespace: biological_process
def: "A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling." [GOC:bf, GOC:bhm, PMID:17097674, PMID:17360520]
subset: goslim_prokaryote
synonym: "bacterial nucleoid DNA packaging" EXACT []
synonym: "chromosomal compaction" BROAD [PMID:17097674]
synonym: "nucleoid compaction" BROAD [PMID:17097674]
synonym: "prokaryotic DNA condensation" BROAD [Wikipedia:DNA_condensation]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0036387
name: pre-replicative complex
namespace: cellular_component
def: "A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, Wikipedia:Pre-replication_complex]
comment: This term describes pre-replicative complexes across organisms.
synonym: "pre-RC" EXACT [Wikipedia:Pre-replication_complex]
synonym: "pre-replication complex" EXACT [Wikipedia:Pre-replication_complex]
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0036388
name: pre-replicative complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "pre-RC assembly" EXACT [Wikipedia:Pre-replication_complex]
synonym: "pre-replication complex assembly" RELATED [Wikipedia:Pre-replication_complex]
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0036389
name: bacterial pre-replicative complex
namespace: cellular_component
def: "A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, Wikipedia:Pre-replication_complex]
synonym: "bacterial pre-RC" EXACT [GOC:bf, GOC:bhm, GOC:jh2]
is_a: GO:0036387 ! pre-replicative complex

[Term]
id: GO:0036390
name: pre-replicative complex assembly involved in bacterial-type DNA replication
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, PMID:21895796]
synonym: "bacterial pre-RC assembly" EXACT [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "bacterial pre-replicative complex assembly" EXACT []
is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication

[Term]
id: GO:0036391
name: medial cortex septin ring
namespace: cellular_component
def: "A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins." [GOC:vw, PMID:16009555]
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
relationship: part_of GO:0031097 ! medial cortex

[Term]
id: GO:0036392
name: chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:jc]
subset: gocheck_do_not_annotate
synonym: "C-C motif chemokine 20 production" EXACT []
synonym: "CCL-20 production" EXACT []
synonym: "CCL20 production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0036393
name: thiocyanate peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate." [GOC:pm, PMID:12626341]
synonym: "lactoperoxidase activity" BROAD [PMID:12626341, Wikipedia:Lactoperoxidase]
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0036394
name: amylase secretion
namespace: biological_process
def: "The controlled release of amylase from a cell." [GOC:jc, PMID:19028687]
synonym: "amylase release" EXACT [PMID:19028687]
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0036395
name: pancreatic amylase secretion
namespace: biological_process
def: "The controlled release of amylase from a cell of the pancreas." [GOC:jc, PMID:19028687]
is_a: GO:0036394 ! amylase secretion
relationship: part_of GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:0036396
name: RNA N6-methyladenosine methyltransferase complex
namespace: cellular_component
def: "A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B)." [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716]
synonym: "m(6)A writer complex" RELATED []
synonym: "m6A methyltransferase complex" RELATED []
synonym: "METTL3-METTL14-WTAP methyltransferase complex" RELATED []
synonym: "MIS complex" RELATED []
synonym: "Mum2, Ime4, and Slz1 complex" EXACT [PMID:22685417]
synonym: "WMM complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0036397
name: formate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + a quinone = CO2 + a quinol." [GOC:bhm, RHEA:48592]
synonym: "Fdh-N activity" RELATED []
synonym: "formate dehydrogenase-N activity" RELATED [EC:1.17.5.3]
synonym: "formate:quinone oxidoreductase activity" RELATED []
xref: EC:1.17.5.3
xref: KEGG_REACTION:R09494
xref: MetaCyc:FORMATEDEHYDROG-RXN
xref: RHEA:48592
is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

[Term]
id: GO:0036398
name: TCR signalosome
namespace: cellular_component
def: "A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology." [GOC:krc, PMID:17534068, PMID:20107804, PMID:22426112]
synonym: "LAT signalosome" EXACT [GOC:krc, PMID:17534068]
synonym: "linker for activation of T cells signalosome" EXACT [PMID:17534068]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0036399
name: TCR signalosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome." [GOC:krc, PMID:22426112]
synonym: "LAT signalosome assembly" EXACT [GOC:krc, PMID:17534068]
synonym: "linker for activation of T cells signalosome assembly" EXACT [PMID:17534068]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0036400
name: short neuropeptide F receptor activity
namespace: molecular_function
def: "Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide." [GOC:ha, PMID:16330127, PMID:21440021]
comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related.
synonym: "sNPF receptor activity" EXACT [PMID:12372405, PMID:21440021]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0036401
name: pyrokinin receptor activity
namespace: molecular_function
def: "Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060]
synonym: "PK receptor activity" EXACT [PMID:17065249]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0036402
name: proteasome-activating activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818]
synonym: "ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:bf]
synonym: "proteasomal ATPase activity" EXACT [GOC:bf]
synonym: "proteasome channel gating activity" NARROW [GOC:rb]
synonym: "proteasome channel opening activity" NARROW [GOC:rb]
synonym: "proteasome-activating ATPase activity" EXACT []
xref: EC:5.6.1.5
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0036403
name: arachidonate 8(S)-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [GOC:lb, PMID:10625675, RHEA:38675]
comment: This activity produces the S-enantiomer of HPETE, 8(S)-HPETE. For the reaction producing the S-enantiomer, see GO:0047677.
synonym: "8(S)-lipoxygenase activity" BROAD [GOC:bf]
synonym: "8-lipoxygenase (S-type)" BROAD [KEGG_REACTION:R07053]
xref: KEGG_REACTION:R07053
xref: RHEA:38675
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0036404
name: obsolete conversion of ds siRNA to ss siRNA
namespace: biological_process
def: "OBSOLETE. The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA)." [GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA" RELATED [GOC:bf]
is_obsolete: true
consider: GO:0004521

[Term]
id: GO:0036405
name: obsolete anchored component of cell outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:md]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "anchored to cell outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009279

[Term]
id: GO:0036406
name: obsolete anchored component of periplasmic side of cell outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only." [GOC:dos, GOC:md]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "anchored to internal side of cell outer membrane" EXACT []
synonym: "anchored to periplasmic side of cell outer membrane" NARROW []
is_obsolete: true
replaced_by: GO:0031241

[Term]
id: GO:0036407
name: mycolate outer membrane
namespace: cellular_component
def: "A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria)." [GOC:bf, GOC:das, GOC:md, PMID:18316738, PMID:18567661]
synonym: "MOM" EXACT [GOC:md]
synonym: "mycobacterial outer membrane" EXACT [GOC:md]
synonym: "mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0009279 ! cell outer membrane

[Term]
id: GO:0036408
name: histone H3K14 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)." [GOC:vw, PMID:18552846, PMID:19056256, PMID:21289066]
synonym: "histone acetylase activity (H3-K14 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K14 specific)" EXACT []
synonym: "histone H3-K14 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K14 specific)" EXACT [GOC:bf]
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0036409
name: histone H3-K14 acetyltransferase complex
namespace: cellular_component
def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3." [GOC:vw, PMID:21289066]
synonym: "H3-K14 histone acetyltransferase complex" EXACT [GOC:bf]
synonym: "histone acetyltransferase complex (H3-K14 specific)" EXACT [GOC:bf]
synonym: "histone H3 Lys 14 (H3K14) acetyltransferase complex" EXACT [PMID:21289066]
synonym: "histone H3K14 acetyltransferase complex" EXACT [PMID:21289066]
is_a: GO:0070775 ! H3 histone acetyltransferase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0036410
name: Mst2 histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6." [GOC:vw, PMID:21289066]
synonym: "Mst2 complex" EXACT [PMID:21289066]
synonym: "Mst2 H3K14 acetyltransferase complex" EXACT [PMID:21289066]
synonym: "Mst2 histone H3K14 acetyltransferase complex" EXACT [PMID:21289066]
is_a: GO:0036409 ! histone H3-K14 acetyltransferase complex

[Term]
id: GO:0036411
name: H-NS-Cnu complex
namespace: cellular_component
def: "A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:18189420, PMID:22358512]
is_a: GO:0017053 ! transcription repressor complex

[Term]
id: GO:0036412
name: acetyl-CoA:oxalate CoA-transferase
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA." [GOC:imk, PMID:23935849]
xref: RHEA:37883
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0036413
name: obsolete histone H3-R26 citrullination
namespace: biological_process
def: "OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3." [GOC:als, PMID:22853951]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 arginine 26 citrullination" EXACT [GOC:als]
is_obsolete: true
consider: GO:0140798

[Term]
id: GO:0036414
name: obsolete histone citrullination
namespace: biological_process
def: "OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein." [GOC:als, PMID:22853951, PMID:23175390]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone deimination" EXACT [Wikipedia:Citrullination]
is_obsolete: true
consider: GO:0140794

[Term]
id: GO:0036415
name: regulation of tRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs." [GOC:aa, PMID:21502523, PMID:23572593]
is_a: GO:0043487 ! regulation of RNA stability
is_a: GO:1902370 ! regulation of tRNA catabolic process

[Term]
id: GO:0036416
name: tRNA stabilization
namespace: biological_process
def: "Prevention of degradation of tRNA molecules." [GOC:aa, GOC:bf, PMID:20459084]
is_a: GO:0036415 ! regulation of tRNA stability
is_a: GO:0043489 ! RNA stabilization
is_a: GO:1902371 ! negative regulation of tRNA catabolic process

[Term]
id: GO:0036417
name: tRNA destabilization
namespace: biological_process
def: "Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes." [GOC:aa, GOC:bf]
is_a: GO:0036415 ! regulation of tRNA stability
is_a: GO:0050779 ! RNA destabilization
is_a: GO:1902372 ! positive regulation of tRNA catabolic process

[Term]
id: GO:0036418
name: obsolete intrinsic component of mycolate outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:md]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to MOM" EXACT [GOC:md]
synonym: "intrinsic to mycolate outer membrane" NARROW []
synonym: "intrinsic to mycomembrane" EXACT [GOC:das, GOC:md]
is_obsolete: true
replaced_by: GO:0036407

[Term]
id: GO:0036419
name: obsolete integral component of mycolate outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:md]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to MOM" EXACT [GOC:md]
synonym: "integral to mycolate outer membrane" NARROW []
synonym: "integral to mycomembrane" EXACT [GOC:das, GOC:md]
is_obsolete: true
replaced_by: GO:0036407

[Term]
id: GO:0036420
name: extrinsic component of mycolate outer membrane
namespace: cellular_component
def: "The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:md]
synonym: "extrinsic to MOM" EXACT [GOC:md]
synonym: "extrinsic to mycolate outer membrane" NARROW []
synonym: "extrinsic to mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0031244 ! extrinsic component of cell outer membrane
relationship: part_of GO:0036407 ! mycolate outer membrane

[Term]
id: GO:0036421
name: extrinsic component of external side of mycolate outer membrane
namespace: cellular_component
def: "The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:md]
synonym: "extrinsic to external side of MOM" EXACT [GOC:md]
synonym: "extrinsic to external side of mycolate outer membrane" NARROW []
synonym: "extrinsic to external side of mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0031242 ! extrinsic component of external side of cell outer membrane
is_a: GO:0036420 ! extrinsic component of mycolate outer membrane
relationship: part_of GO:0098568 ! external side of mycolate outer membrane

[Term]
id: GO:0036423
name: hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.83, RHEA:27559]
synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.83]
synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.83]
synonym: "HexPS activity" EXACT [EC:2.5.1.83]
xref: EC:2.5.1.83
xref: KEGG_REACTION:R09245
xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN
xref: RHEA:27559
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0036424
name: L-phosphoserine phosphatase activity
namespace: molecular_function
alt_id: GO:0004647
def: "Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid." [PMID:25037224, PMID:9188776, RHEA:21208]
comment: Do not confuse with protein phosphatases. For protein phosphatases, consider GO:0004722 ; protein serine/threonine phosphatase activity or GO:0008138 ; protein tyrosine/serine/threonine phosphatase activity.
synonym: "O-phosphoserine phosphohydrolase activity" RELATED [EC:3.1.3.3]
synonym: "phosphoserine phosphatase activity" RELATED []
xref: KEGG_REACTION:R00582
xref: MetaCyc:RXN0-5114
xref: Reactome:R-HSA-977324 "PSPH:Mg2+ dimer dephosphorylates O-P-Ser"
xref: RHEA:21208
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0036425
name: obsolete D-phosphoserine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O-phospho-D-serine + H2O = L-serine + phosphate, on a free amino acid." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this function exists. This reaction corresponds to RHEA:24873 and KEGG_REACTION:R02853.
is_obsolete: true
consider: GO:0036424

[Term]
id: GO:0036426
name: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [GOC:curators]
xref: KEGG_REACTION:R07257
xref: MetaCyc:2.4.1.54-RXN
is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity

[Term]
id: GO:0036427
name: all-trans-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:28118]
xref: RHEA:28118
is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity

[Term]
id: GO:0036428
name: obsolete adenosylcobinamide kinase (GTP-specific) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+." [GOC:rynl]
comment: The reason for obsoletion is that this is more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0043752

[Term]
id: GO:0036429
name: obsolete adenosylcobinamide kinase (ATP-specific) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+." [GOC:rynl]
comment: The reason for obsoletion is that this is more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0043752

[Term]
id: GO:0036430
name: CMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CMP = ADP + CDP." [RHEA:11600]
xref: KEGG_REACTION:R00512
xref: MetaCyc:RXN-11832
xref: RHEA:11600
is_a: GO:0004127 ! (d)CMP kinase activity

[Term]
id: GO:0036431
name: dCMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dCMP = ADP + dCDP." [RHEA:25094]
synonym: "ATP:dCMP phosphotransferase activity" EXACT [KEGG_REACTION:R01665]
xref: KEGG_REACTION:R01665
xref: MetaCyc:RXN-7913
xref: RHEA:25094
is_a: GO:0004127 ! (d)CMP kinase activity

[Term]
id: GO:0036432
name: all-trans undecaprenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+." [RHEA:23752]
xref: RHEA:23752
is_a: GO:0009038 ! undecaprenol kinase activity

[Term]
id: GO:0036433
name: di-trans, poly-cis-undecaprenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+." [RHEA:28122]
synonym: "ditrans,polycis-undecaprenol kinase activity" RELATED []
xref: EC:2.7.1.66
xref: KEGG_REACTION:R05626
xref: MetaCyc:UNDECAPRENOL-KINASE-RXN
xref: RHEA:28122
is_a: GO:0009038 ! undecaprenol kinase activity

[Term]
id: GO:0036434
name: nitronate monooxygenase (FMN-linked) activity
namespace: molecular_function
def: "Catalysis of the reaction: ethylnitronate + FMNH(2) + O2 = acetaldehyde + FMN + H2O + H+ + nitrite." [RHEA:26458]
xref: KEGG_REACTION:R00025
xref: RHEA:26458
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0036435
name: K48-linked polyubiquitin modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein." [GOC:al, PMID:20739285]
xref: Reactome:R-HSA-5683077 "RNF8 and RNF168 ubiquitinate KDM4A,B"
is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding

[Term]
id: GO:0036436
name: Isw1a complex
namespace: cellular_component
def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p." [GOC:jd, PMID:12482963]
is_a: GO:0016587 ! Isw1 complex

[Term]
id: GO:0036437
name: Isw1b complex
namespace: cellular_component
def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p." [GOC:jd, PMID:12482963]
is_a: GO:0016587 ! Isw1 complex

[Term]
id: GO:0036438
name: maintenance of lens transparency
namespace: biological_process
def: "A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina." [GOC:nhn, PMID:22095752]
synonym: "maintenance of ocular lens transparency" EXACT [PMID:22095752]
synonym: "preservation of lens transparency" EXACT [PMID:22095752]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0036440
name: citrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA." [RHEA:16845]
xref: EC:2.3.3.16
xref: KEGG_REACTION:R00351
xref: MetaCyc:CITSYN-RXN
xref: RHEA:16845
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0036441
name: 2-dehydropantolactone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+." [RHEA:18981]
xref: KEGG_REACTION:R03155
xref: RHEA:18981
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0036443
name: obsolete dermatan 6-sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate." [GOC:bf, KEGG_REACTION:R07288]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0036444
name: calcium import into the mitochondrion
namespace: biological_process
def: "A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix." [GOC:vw]
synonym: "calcium ion import into mitochondrion" BROAD []
synonym: "calcium ion transmembrane import into mitochondrion" EXACT []
synonym: "mitochondrial calcium ion import" BROAD [GOC:vw]
synonym: "mitochondrial calcium uptake" EXACT []
is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:0036445
name: neuronal stem cell division
namespace: biological_process
def: "The self-renewing division of a neuronal stem cell." [CL:0000047, GOC:nhn]
synonym: "NSC division" EXACT [CL:0000047]
is_a: GO:0048103 ! somatic stem cell division

[Term]
id: GO:0036446
name: myofibroblast differentiation
namespace: biological_process
def: "The process in which an undifferentiated cell acquires the features of a myofibroblast cell." [CL:0000186, GOC:nhn]
synonym: "myofibroblast cell differentiation" EXACT [CL:0000186]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0036447
name: cellular response to sugar-phosphate stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate." [GOC:am, PMID:17383224]
synonym: "cellular response to presence of non-metabolizable sugars" RELATED [GOC:am]
is_a: GO:0062197 ! cellular response to chemical stress

[Term]
id: GO:0036448
name: cellular response to glucose-phosphate stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate." [GOC:am, PMID:17383224]
is_a: GO:0036447 ! cellular response to sugar-phosphate stress

[Term]
id: GO:0036449
name: microtubule minus-end
namespace: cellular_component
def: "The end of a microtubule that does not preferentially grow (polymerize)." [GOC:lb, PMID:23169647]
synonym: "microtubule minus end" EXACT [GOC:lb]
is_a: GO:1990752 ! microtubule end

[Term]
id: GO:0036450
name: polyuridylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end." [GOC:vw, PMID:19430462]
synonym: "uridylation-dependent decapping of nuclear-transcribed mRNA" BROAD [GOC:vw]
is_a: GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA
relationship: part_of GO:1990074 ! polyuridylation-dependent mRNA catabolic process

[Term]
id: GO:0036451
name: obsolete cap mRNA methylation
namespace: biological_process
def: "OBSOLETE. Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA." [GOC:bf, PMID:20713356]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006370

[Term]
id: GO:0036452
name: ESCRT complex
namespace: cellular_component
def: "An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]
synonym: "endosomal sorting complex required for transport" EXACT [PMID:22718754]
xref: Wikipedia:ESCRT
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0036453
name: transitive RNA interference
namespace: biological_process
def: "An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence." [GOC:pf, PMID:11719187, PMID:12554873, PMID:23724097, PMID:24369430]
synonym: "transitive RNAi" EXACT [PMID:12554873]
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0036454
name: growth factor complex
namespace: cellular_component
def: "A protein complex that has growth factor activity." [GOC:bhm]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0036455
name: iron-sulfur transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)." [GOC:bhm]
synonym: "Fe-S transferase activity" EXACT [GOC:bf]
xref: Reactome:R-HSA-2564828 "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins"
is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups

[Term]
id: GO:0036456
name: L-methionine-(S)-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O." [GOC:vw, RHEA:19995]
xref: RHEA:19995
is_a: GO:0033744 ! L-methionine:thioredoxin-disulfide S-oxidoreductase activity

[Term]
id: GO:0036457
name: keratohyalin granule
namespace: cellular_component
def: "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0036458
name: hepatocyte growth factor binding
namespace: molecular_function
def: "Binding to a hepatocyte growth factor." [GOC:curators]
synonym: "HGF binding" EXACT [PR:000008534]
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0036460
name: cellular response to cell envelope stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope." [GOC:imk, PMID:15101969, PMID:15882407]
synonym: "envelope stress response" EXACT [PMID:15882407]
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0036461
name: BLOC-2 complex binding
namespace: molecular_function
def: "Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules." [GOC:bf, GOC:PARL, PMID:22511774]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0036462
name: TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface." [GOC:bf, GOC:PARL, PMID:21785459]
synonym: "TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "TRAIL-induced apoptotic signaling pathway" EXACT [PMID:21785459]
synonym: "tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [PMID:21785459]
is_a: GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors

[Term]
id: GO:0036463
name: TRAIL receptor activity
namespace: molecular_function
def: "Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death." [GOC:bf, GOC:PARL]
synonym: "tumor necrosis factor-related apoptosis-inducing ligand receptor" EXACT [PMID:21785459]
is_a: GO:0005035 ! death receptor activity

[Term]
id: GO:0036464
name: cytoplasmic ribonucleoprotein granule
namespace: cellular_component
def: "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]
synonym: "Staufen granule" NARROW [PMID:15121898]
is_a: GO:0035770 ! ribonucleoprotein granule
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0036465
name: synaptic vesicle recycling
namespace: biological_process
def: "The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]
synonym: "kiss-and-run synaptic vesicle recycling" NARROW [PMID:15217342]
synonym: "kiss-and-stay synaptic vesicle recycling" NARROW [PMID:15217342]
is_a: GO:0006810 ! transport
is_a: GO:0051649 ! establishment of localization in cell
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0036466
name: synaptic vesicle recycling via endosome
namespace: biological_process
alt_id: GO:0099090
def: "Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate." [GOC:aruk, GOC:bc, GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342]
subset: goslim_synapse
synonym: "recycling endosome localization within postsynapse" EXACT []
is_a: GO:0036465 ! synaptic vesicle recycling
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing

[Term]
id: GO:0036467
name: 5-hydroxy-L-tryptophan decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin." [GOC:bf, GOC:PARL, RHEA:18533]
synonym: "5-hydroxytryptophan decarboxylase activity" BROAD [EC:4.1.1.28]
xref: RHEA:18533
is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity

[Term]
id: GO:0036468
name: L-dopa decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine." [GOC:bf, GOC:PARL, RHEA:12272]
synonym: "4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [PMID:19703902]
synonym: "DDC activity" EXACT [PMID:19703902]
synonym: "DOPA decarboxylase activity" RELATED [EC:4.1.1.28]
xref: RHEA:12272
is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity

[Term]
id: GO:0036469
name: L-tryptophan decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine." [GOC:bf, GOC:PARL, RHEA:30339]
xref: EC:4.1.1.105
xref: RHEA:30339
is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity

[Term]
id: GO:0036470
name: tyrosine 3-monooxygenase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase)." [GOC:bf, GOC:PARL, PMID:19703902]
synonym: "TH activator activity" EXACT [PMID:19703902]
synonym: "tyrosine hydroxylase activator activity" EXACT [PMID:19703902]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0036471
name: cellular response to glyoxal
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus." [GOC:bf, GOC:PARL]
is_a: GO:0110096 ! cellular response to aldehyde

[Term]
id: GO:0036472
name: obsolete suppression by virus of host protein-protein interaction
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins." [GOC:bf, GOC:PARL, PMID:17297443]
comment: This term was obsoleted because it represents a molecular function.
synonym: "suppression by virus of host protein binding" EXACT [GOC:bf]
synonym: "suppression by virus of host protein interaction" EXACT [GOC:bf]
synonym: "suppression by virus of host protein:protein binding" EXACT [GOC:bf]
synonym: "suppression by virus of host protein:protein interaction" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0098772
consider: GO:0140311

[Term]
id: GO:0036473
name: obsolete cell death in response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
is_obsolete: true

[Term]
id: GO:0036474
name: obsolete cell death in response to hydrogen peroxide
namespace: biological_process
def: "OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "cell death in response to H2O2" EXACT [GOC:bf]
synonym: "hydrogen peroxide-mediated cell death" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036475
name: obsolete neuron death in response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL]
comment: The reason for obsoletion is that this term often represents an assay, or a phenotype and not a GO process.
synonym: "neuronal cell death in response to oxidative stress" EXACT [GOC:bf]
synonym: "oxidative stress-induced neuron death" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036476
name: obsolete neuron death in response to hydrogen peroxide
namespace: biological_process
def: "OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "hydrogen peroxide-induced neuron death" EXACT [GOC:bf]
synonym: "neuron death in response to H2O2" EXACT [GOC:bf]
synonym: "neuronal cell death in response to hydrogen peroxide" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036477
name: somatodendritic compartment
namespace: cellular_component
def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0036478
name: L-dopa decarboxylase activator activity
namespace: molecular_function
def: "Interacts with and increases L-dopa decarboxylase activity." [GOC:bf, GOC:PARL]
comment: GO:0036478 is reserved for cases when the activator directly interacts with L-dopa decarboxylase. When activation of L-dopa decarboxylase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'positive regulation of L-dopa decarboxylase activity ; GO:1903200'.
synonym: "DDC activator activity" EXACT [GOC:bf]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0036479
name: peroxidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of peroxidase." [GOC:bf, GOC:PARL]
comment: GO:0036479 is reserved for cases when the inhibitor directly interacts with the peroxidase. When inhibition of peroxidase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'negative regulation of peroxidase activity ; GO:2000469'.
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0036480
name: neuron intrinsic apoptotic signaling pathway in response to oxidative stress
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059]
synonym: "neuron apoptosis in response to oxidative stress" RELATED [GOC:bf]
synonym: "oxidative stress-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "oxidative stress-induced neuronal apoptosis" BROAD [GOC:bf]
is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: part_of GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0036481
name: intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]
synonym: "H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:bf]
synonym: "hydrogen peroxide-induced apoptosis" BROAD [GOC:bf]
synonym: "hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf]
is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: part_of GO:0010421 ! hydrogen peroxide-mediated programmed cell death

[Term]
id: GO:0036482
name: neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide." [GOC:bf, GOC:PARL]
synonym: "H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:bf]
synonym: "neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:bf]
synonym: "neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf]
is_a: GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
is_a: GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide

[Term]
id: GO:0036483
name: neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:bf, GOC:PARL, PMID:21113145]
synonym: "endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "ER stress-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
is_a: GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
relationship: part_of GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0036484
name: trunk neural crest cell migration
namespace: biological_process
def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]
synonym: "trunk NCC migration" EXACT [PMID:2387238]
is_a: GO:0001755 ! neural crest cell migration
relationship: part_of GO:0035290 ! trunk segmentation

[Term]
id: GO:0036485
name: dorsolateral trunk neural crest cell migration
namespace: biological_process
def: "The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]
synonym: "dorsolateral trunk NCC migration" EXACT [PMID:2387238]
is_a: GO:0036484 ! trunk neural crest cell migration

[Term]
id: GO:0036486
name: ventral trunk neural crest cell migration
namespace: biological_process
def: "The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta." [GOC:bf, GOC:mat, GOC:PARL, PMID:16319111, PMID:19386662]
synonym: "trunk NCC migration through anterior sclerotome" EXACT [PMID:19386662]
synonym: "trunk NCC migration within somite" EXACT [GOC:mat]
synonym: "ventral trunk NCC migration" EXACT [GOC:bf]
is_a: GO:0036484 ! trunk neural crest cell migration

[Term]
id: GO:0036487
name: nitric-oxide synthase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of nitric oxide synthase." [GOC:BHF, GOC:rl, PMID:17242280]
synonym: "nitric oxide synthase inhibitor activity" EXACT [GOC:bf]
synonym: "NOS inhibitor activity" EXACT [GOC:bf]
xref: Reactome:R-HSA-203712 "eNOS associates with Caveolin-1"
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0030235 ! nitric-oxide synthase regulator activity

[Term]
id: GO:0036488
name: CHOP-C/EBP complex
namespace: cellular_component
def: "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942]
synonym: "CHOP-C/EBP dimer" EXACT [PMID:8657121]
synonym: "CHOP-C/EBP heterodimer" EXACT [PMID:8657121]
synonym: "GADD153-C/EBP complex" EXACT [PMID:8657121]
synonym: "GADD153-C/EBP-alpha complex" NARROW [PMID:8657121]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0036489
name: neuromelanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers." [GOC:bf, GOC:PARL, Wiki:Neuromelanin]
synonym: "neuromelanin anabolism" EXACT [GOC:bf]
synonym: "neuromelanin biosynthesis" EXACT [GOC:bf]
synonym: "neuromelanin formation" EXACT [GOC:bf]
synonym: "neuromelanin synthesis" EXACT [GOC:bf]
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0036490
name: regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]
synonym: "regulation of translation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0043555 ! regulation of translation in response to stress
relationship: part_of GO:0034976 ! response to endoplasmic reticulum stress

[Term]
id: GO:0036491
name: regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]
synonym: "regulation of translation initiation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0036492
name: eiF2alpha phosphorylation in response to endoplasmic reticulum stress
namespace: biological_process
def: "The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]
subset: gocheck_obsoletion_candidate
synonym: "eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:bf]
synonym: "regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf]
is_a: GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress

[Term]
id: GO:0036493
name: positive regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]
synonym: "positive regulation of translation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress

[Term]
id: GO:0036494
name: positive regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]
synonym: "positive regulation of translation initiation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress
is_a: GO:0036493 ! positive regulation of translation in response to endoplasmic reticulum stress

[Term]
id: GO:0036495
name: negative regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]
synonym: "negative regulation of translation initiation in response to ER stress" RELATED [GOC:bf]
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress
is_a: GO:1902010 ! negative regulation of translation in response to endoplasmic reticulum stress

[Term]
id: GO:0036496
name: regulation of translational initiation by eIF2 alpha dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha." [GOC:bf, GOC:PARL]
subset: gocheck_obsoletion_candidate
is_a: GO:0006470 ! protein dephosphorylation
is_a: GO:0032535 ! regulation of cellular component size
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0036497
name: eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
namespace: biological_process
def: "The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:16835242]
subset: gocheck_obsoletion_candidate
synonym: "eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:bf]
synonym: "regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf]
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress
is_a: GO:0036496 ! regulation of translational initiation by eIF2 alpha dephosphorylation

[Term]
id: GO:0036498
name: IRE1-mediated unfolded protein response
namespace: biological_process
def: "The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB." [GOC:bf, GOC:PARL, PMID:22013210]
comment: Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
synonym: "endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:bf]
synonym: "ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "inositol-requiring enzyme 1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [PMID:22013210]
synonym: "IRE1 branch of UPR" EXACT [GOC:bf]
synonym: "IRE1 signal transduction pathway" BROAD [GOC:bf]
synonym: "IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "IRE1alpha unfolded protein response" NARROW [PMID:22013210]
synonym: "IRE1p unfolded protein response" NARROW [PMID:22013210]
synonym: "UPR signaling by IRE1 stress sensor" EXACT [GOC:bf]
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:0036499
name: PERK-mediated unfolded protein response
namespace: biological_process
def: "The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041]
synonym: "EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:bf]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "PERK branch of UPR" EXACT [GOC:bf]
synonym: "PERK signal transduction pathway" BROAD [GOC:bf]
synonym: "PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "PKR-like ER kinase signal transduction" EXACT [PMID:22013210]
synonym: "UPR signaling by PERK stress sensor" EXACT [GOC:bf]
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response
is_a: GO:0140467 ! integrated stress response signaling

[Term]
id: GO:0036500
name: ATF6-mediated unfolded protein response
namespace: biological_process
def: "The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210]
synonym: "activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:bf]
synonym: "ATF6 branch of UPR" EXACT [GOC:bf]
synonym: "ATF6 signal transduction pathway" BROAD [GOC:bf]
synonym: "ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "ATF6-alpha UPR branch" NARROW [GOC:bf]
synonym: "ATF6-beta UPR branch" NARROW [GOC:bf]
synonym: "endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:bf]
synonym: "UPR signaling by ATF6 stress sensor" EXACT [GOC:bf]
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:0036501
name: UFD1-NPL4 complex
namespace: cellular_component
def: "A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p." [GOC:bf, GOC:PARL, PMID:10811609, PMID:17289586]
synonym: "Npl4p-Ufd1p complex" EXACT [PMID:17289586]
synonym: "Ufd1-Npl4 binary complex" EXACT [PMID:10811609]
synonym: "Ufd1-Npl4 cofactor complex" EXACT [PMID:10811609]
synonym: "Ufd1/Npl4 complex" EXACT [PMID:10811609]
synonym: "UFD1L-NPLOC4 complex" EXACT [GOC:bf]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0036502
name: Derlin-1-VIMP complex
namespace: cellular_component
def: "A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]
synonym: "Derlin-1/VIMP complex" EXACT [PMID:15215856]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0036503
name: ERAD pathway
namespace: biological_process
def: "The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]
comment: ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
synonym: "endoplasmic reticulum-associated degradation" EXACT [PMID:22535891]
synonym: "endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:bf]
synonym: "ER-associated degradation pathway" RELATED [PMID:24699081]
synonym: "protein degradation by ERAD" EXACT [GOC:bf]
is_a: GO:0010498 ! proteasomal protein catabolic process
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0036504
name: Golgi membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691]
synonym: "Golgi apparatus membrane fusion" EXACT []
synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf]
synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609]
is_a: GO:0090174 ! organelle membrane fusion
relationship: part_of GO:0090168 ! Golgi reassembly

[Term]
id: GO:0036505
name: prosaposin receptor activity
namespace: molecular_function
def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493]
synonym: "prosaposin-activated receptor activity" EXACT [GOC:bf]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0036506
name: maintenance of unfolded protein
namespace: biological_process
def: "Maintaining a protein in an unfolded, soluble state." [GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, PMID:21636303]
is_a: GO:0031647 ! regulation of protein stability

[Term]
id: GO:0036507
name: protein demannosylation
namespace: biological_process
def: "The removal of one or more mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:25092655]
comment: Consider also annotating to the term 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
subset: gocheck_obsoletion_candidate
synonym: "protein de-mannosylation" EXACT [GOC:bf]
is_a: GO:0006517 ! protein deglycosylation

[Term]
id: GO:0036508
name: protein alpha-1,2-demannosylation
namespace: biological_process
def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:21062743, PMID:25092655]
comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
subset: gocheck_obsoletion_candidate
synonym: "glycoprotein mannose trimming" RELATED [GOC:bf]
synonym: "mannose trimming" BROAD [PMID:21062743]
is_a: GO:0036507 ! protein demannosylation

[Term]
id: GO:0036509
name: obsolete trimming of terminal mannose on B branch
namespace: biological_process
def: "OBSOLETE. The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:22160784]
comment: This term was obsoleted because it represents a molecular function.
synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2" RELATED [PMID:22160784]
synonym: "conversion of M9 to M8B" RELATED [PMID:25092655]
synonym: "glycoprotein mannose trimming on B branch" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036510
name: trimming of terminal mannose on C branch
namespace: biological_process
def: "The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:20065073]
comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
subset: gocheck_obsoletion_candidate
synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2" RELATED [PMID:20065073]
synonym: "conversion of M9 to M8C" RELATED [GOC:bf]
synonym: "glycoprotein mannose trimming on C branch" EXACT [GOC:bf]
is_a: GO:1904380 ! endoplasmic reticulum mannose trimming

[Term]
id: GO:0036511
name: obsolete trimming of first mannose on A branch
namespace: biological_process
def: "OBSOLETE. The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701]
comment: This term was obsoleted because it represents a molecular function.
synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2" RELATED [GOC:bf]
synonym: "conversion of M9 to M8A" RELATED [GOC:bf]
synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036512
name: obsolete trimming of second mannose on A branch
namespace: biological_process
def: "OBSOLETE. The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701]
comment: This term was obsoleted because it represents a molecular function.
synonym: "conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2" RELATED [GOC:bf]
synonym: "conversion of M8A to M7AA" RELATED [GOC:bf]
synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf]
is_obsolete: true

[Term]
id: GO:0036513
name: Derlin-1 retrotranslocation complex
namespace: cellular_component
def: "A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]
comment: The Derlin-1 retrotranslocation complex is likely to assemble in steps, thereby containing different components at different stages of the retrotranslocation process.
synonym: "Derlin-1 complex" EXACT [PMID:18555783]
synonym: "Derlin-1 protein dislocation complex" EXACT [PMID:18555783]
synonym: "Derlin-1 retro-translocation complex" EXACT [GOC:bf]
synonym: "Derlin-1 retrotranslocon" EXACT [GOC:bf]
synonym: "ERAD protein dislocation complex" EXACT [PMID:18555783]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0036514
name: dopaminergic neuron axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]
synonym: "DA axon guidance" EXACT [PMID:23517308]
synonym: "dopaminergic axon guidance" EXACT [GOC:bf]
synonym: "mdDA axon guidance" EXACT [PMID:21106844]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0036515
name: serotonergic neuron axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]
synonym: "5-HT axon guidance" EXACT [GOC:bf, PMID:21106844]
synonym: "serotonergic axon guidance" EXACT [GOC:bf]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0036516
name: chemoattraction of dopaminergic neuron axon
namespace: biological_process
def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:bf, GOC:PARL, PMID:21106844]
synonym: "chemoattraction of DA axon" EXACT [GOC:bf]
synonym: "chemoattraction of dopaminergic axon" EXACT [GOC:bf]
is_a: GO:0061642 ! chemoattraction of axon
relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance

[Term]
id: GO:0036517
name: chemoattraction of serotonergic neuron axon
namespace: biological_process
def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]
synonym: "chemoattraction of 5-HT axon" EXACT [GOC:bf, PMID:21106844]
synonym: "chemoattraction of serotonergic axon" EXACT [GOC:bf]
is_a: GO:0061642 ! chemoattraction of axon
relationship: part_of GO:0036515 ! serotonergic neuron axon guidance

[Term]
id: GO:0036518
name: chemorepulsion of dopaminergic neuron axon
namespace: biological_process
def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]
synonym: "chemorepulsion of DA axon" EXACT [GOC:bf, PMID:23517308]
synonym: "chemorepulsion of dopaminergic axon" RELATED [GOC:bf]
is_a: GO:0061643 ! chemorepulsion of axon
relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance

[Term]
id: GO:0036519
name: chemorepulsion of serotonergic neuron axon
namespace: biological_process
def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]
synonym: "chemorepulsion of 5-HT axon" EXACT [GOC:bf, PMID:21106844]
synonym: "chemorepulsion of serotonergic axon" RELATED [GOC:bf]
is_a: GO:0061643 ! chemorepulsion of axon
relationship: part_of GO:0036515 ! serotonergic neuron axon guidance

[Term]
id: GO:0036520
name: astrocyte-dopaminergic neuron signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron." [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258]
synonym: "astrocyte-dopaminergic neuron cell signaling" EXACT [GOC:bf]
synonym: "dopaminergic neuron-astrocyte crosstalk" RELATED [PMID:21752258]
synonym: "mesencephalic dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258]
synonym: "midbrain dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258]
is_a: GO:0150098 ! glial cell-neuron signaling

[Term]
id: GO:0036521
name: obsolete modulation by symbiont of host protein localization to phagocytic vesicle
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modulation by symbiont of host protein localisation to phagosome" RELATED [GOC:bf]
is_obsolete: true
consider: GO:0036522

[Term]
id: GO:0036522
name: symbiont-mediated suppression of host protein localization to phagocytic vesicle
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal localization of a protein to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865]
synonym: "disruption of host protein localisation to phagosome" EXACT [GOC:bf]
synonym: "inhibition of host protein localisation to phagosome" EXACT [GOC:bf]
synonym: "negative regulation by symbiont of host protein localization to phagocytic vesicle" EXACT []
synonym: "suppression of host protein localisation to phagosome" EXACT [GOC:bf]
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0036523
name: obsolete induction by symbiont of host cytokine production
namespace: biological_process
def: "OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865]
comment: This term was obsoleted because it does not represent a real process.
synonym: "'induction by symbiont of host cytokine secretion'" NARROW []
synonym: "induction by symbiont of host cytokine secretion" RELATED [PMID:25063865]
synonym: "positive regulation by symbiont of host cytokine secretion" NARROW []
is_obsolete: true

[Term]
id: GO:0036524
name: protein deglycase activity
namespace: molecular_function
def: "Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal." [EC:3.5.1.124, GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785, PMID:26873906]
synonym: "glyoxylase III" EXACT []
synonym: "protein deglycating enzyme" RELATED [PMID:26873906]
xref: EC:3.5.1.124
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0036525
name: protein deglycation
namespace: biological_process
def: "The removal of a sugar or dicarbonyl from a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]
comment: Glycation is a non enzymatic covalent addition of a sugar or dicarbonyl (methylglyoxal, glyoxal) to a protein. Deglycation repairs the glycated amino acids.
subset: gocheck_obsoletion_candidate
synonym: "glycated protein repair" RELATED [PMID:25416785]
is_a: GO:0030091 ! protein repair
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0036526
name: peptidyl-cysteine deglycation
namespace: biological_process
def: "The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]
subset: gocheck_obsoletion_candidate
synonym: "deglycation of N-acetylcysteine" RELATED [PMID:25416785]
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0036525 ! protein deglycation

[Term]
id: GO:0036527
name: peptidyl-arginine deglycation
namespace: biological_process
def: "The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]
subset: gocheck_obsoletion_candidate
synonym: "deglycation of N-acetylarginine" RELATED [PMID:25416785]
is_a: GO:0018195 ! peptidyl-arginine modification
is_a: GO:0036525 ! protein deglycation

[Term]
id: GO:0036528
name: peptidyl-lysine deglycation
namespace: biological_process
def: "The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]
subset: gocheck_obsoletion_candidate
synonym: "deglycation of N-acetyllysine" RELATED [PMID:25416785]
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0036525 ! protein deglycation

[Term]
id: GO:0036529
name: protein deglycation, glyoxal removal
namespace: biological_process
def: "The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein." [GOC:bf, GOC:PARL, PMID:25416785]
subset: gocheck_obsoletion_candidate
synonym: "protein deglycation of glyoxal-glycated protein" RELATED [PMID:25416785]
is_a: GO:0036525 ! protein deglycation
is_a: GO:0046295 ! glycolate biosynthetic process
is_a: GO:1903189 ! glyoxal metabolic process

[Term]
id: GO:0036530
name: protein deglycation, methylglyoxal removal
namespace: biological_process
def: "The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein." [GOC:bf, GOC:PARL, PMID:25416785]
subset: gocheck_obsoletion_candidate
synonym: "protein deglycation of methylglyoxal-glycated protein" RELATED [PMID:25416785]
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0019249 ! lactate biosynthetic process
is_a: GO:0036525 ! protein deglycation

[Term]
id: GO:0036531
name: obsolete glutathione deglycation
namespace: biological_process
def: "OBSOLETE. The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine." [GOC:bf, GOC:PARL, PMID:25416785]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0038001
name: paracrine signaling
namespace: biological_process
def: "The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other." [GOC:mtg_signaling_feb11, ISBN:3527303782]
comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from endocrine signaling.
synonym: "paracrine signalling" EXACT [GOC:bf]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0038002
name: endocrine signaling
namespace: biological_process
def: "The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other." [GOC:mtg_signaling_feb11, ISBN:0199264678, ISBN:3527303782]
comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from paracrine signaling.
synonym: "endocrine signalling" EXACT [GOC:bf]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0050886 ! endocrine process

[Term]
id: GO:0038003
name: G protein-coupled opioid receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:bf, PMID:20494127]
synonym: "opioid receptor signaling pathway" BROAD []
synonym: "opioid receptor signalling pathway" EXACT [GOC:mah]
xref: Wikipedia:Opioid_receptor
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038004
name: epidermal growth factor receptor ligand maturation
namespace: biological_process
alt_id: GO:0038005
def: "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524, PMID:11672525]
synonym: "EGFR ligand maturation" EXACT [GOC:bf]
synonym: "EGFR ligand maturation by peptide bond cleavage" NARROW [GOC:bf]
synonym: "EGFR ligand processing" NARROW [GOC:bf]
synonym: "epidermal growth factor receptor ligand processing" RELATED [GOC:bf]
synonym: "peptide bond cleavage involved in EGFR ligand maturation" NARROW [GOC:bf]
synonym: "peptide bond cleavage involved in epidermal growth factor receptor ligand maturation" RELATED []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0038006
name: netrin receptor activity involved in chemoattraction
namespace: molecular_function
def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin." [GOC:signaling]
synonym: "attractive netrin receptor activity" EXACT [GOC:bf]
synonym: "netrin receptor activity involved in positive chemotaxis" EXACT [GOC:bf]
is_a: GO:0005042 ! netrin receptor activity

[Term]
id: GO:0038007
name: netrin-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]
synonym: "netrin signaling pathway" EXACT [GOC:bf]
synonym: "netrin-activated signal transduction pathway" EXACT [GOC:bf]
synonym: "netrin-activated signalling pathway" EXACT [GOC:bf]
synonym: "netrin-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0038008
name: obsolete TRAF-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components." [GOC:bf, PMID:19918944, PMID:20596822]
comment: This term was obsoleted because it represents an activity present in multiple different pathways.
synonym: "TRAF signaling" EXACT [GOC:bf]
synonym: "TRAF-mediated intracellular signaling" EXACT [GOC:bf]
synonym: "TRAF-mediated signaling" EXACT [GOC:bf]
synonym: "TRAF-mediated signalling" EXACT [GOC:bf]
synonym: "tumor necrosis factor receptor-associated factor signal transduction" EXACT [GOC:bf]
synonym: "tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0038009
name: regulation of signal transduction by receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway." [GOC:bf, GOC:signaling, PMID:17011816, PMID:19696798]
synonym: "regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031623 ! receptor internalization

[Term]
id: GO:0038010
name: positive regulation of signal transduction by receptor internalization
namespace: biological_process
def: "Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]
synonym: "positive regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0038009 ! regulation of signal transduction by receptor internalization

[Term]
id: GO:0038011
name: negative regulation of signal transduction by receptor internalization
namespace: biological_process
def: "Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]
synonym: "negative regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0038009 ! regulation of signal transduction by receptor internalization

[Term]
id: GO:0038012
name: obsolete negative regulation of Wnt signaling pathway by Wnt receptor internalization
namespace: biological_process
def: "OBSOLETE. Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction." [GOC:bf, GOC:BHF, GOC:rl, PMID:17908284, PMID:19643732]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "ligand-dependent internalization of Frizzled" NARROW [PMID:19643732]
synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor endocytosis" NARROW [GOC:bf]
synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway by Wnt receptor internalization" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway by Wnt receptor internalization" EXACT [GOC:signaling]
is_obsolete: true
replaced_by: GO:0030178

[Term]
id: GO:0038013
name: obsolete positive regulation of Wnt signaling pathway by Wnt receptor internalization
namespace: biological_process
def: "OBSOLETE. Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway." [GOC:bf, GOC:signaling, PMID:17908284]
comment: This term was obsoleted because there is no evidence that this process exists. Endocytosis of the ligand is part of the signaling pathway.
synonym: "positive regulation of Wnt receptor signaling pathway by Frizzled internalization" RELATED []
synonym: "positive regulation of Wnt receptor signaling pathway by LRP6 internalization" NARROW [GOC:bf]
synonym: "positive regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway by Wnt receptor endocytosis" EXACT [GOC:bf]
synonym: "positive regulation of Wnt-activated signaling pathway by Wnt receptor internalization" RELATED [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038014
name: negative regulation of insulin receptor signaling pathway by insulin receptor internalization
namespace: biological_process
def: "Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation." [GOC:bf, GOC:signaling, PMID:18492485, PMID:7821727, PMID:7978876, PMID:9609114]
synonym: "agonist-stimulated insulin receptor internalization" BROAD [PMID:18492485]
synonym: "negative regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah]
is_a: GO:0038011 ! negative regulation of signal transduction by receptor internalization
is_a: GO:0038016 ! insulin receptor internalization
is_a: GO:0046627 ! negative regulation of insulin receptor signaling pathway

[Term]
id: GO:0038015
name: positive regulation of insulin receptor signaling pathway by insulin receptor internalization
namespace: biological_process
def: "Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane." [GOC:bf, GOC:signaling, PMID:9609114]
synonym: "positive regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah]
is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization
is_a: GO:0038016 ! insulin receptor internalization
is_a: GO:0046628 ! positive regulation of insulin receptor signaling pathway

[Term]
id: GO:0038016
name: insulin receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:3907718, PMID:9609114]
synonym: "insulin receptor endocytosis" BROAD [GOC:bf]
is_a: GO:0031623 ! receptor internalization

[Term]
id: GO:0038017
name: Wnt receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:17908284]
synonym: "Wnt receptor endocytosis" BROAD [GOC:bf]
is_a: GO:0031623 ! receptor internalization

[Term]
id: GO:0038018
name: Wnt receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:BHF, GOC:rl, GOC:signaling, PMID:19643732]
synonym: "Frizzled degradation" NARROW [PMID:19643732]
synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation" EXACT [GOC:bf]
synonym: "Wnt receptor breakdown" EXACT [GOC:bf]
synonym: "Wnt receptor catabolism" EXACT [GOC:bf]
synonym: "Wnt receptor degradation" RELATED [GOC:bf]
is_a: GO:0032801 ! receptor catabolic process
relationship: part_of GO:0030178 ! negative regulation of Wnt signaling pathway

[Term]
id: GO:0038019
name: Wnt receptor recycling
namespace: biological_process
def: "The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:19643732]
synonym: "Frizzled recycling" NARROW [PMID:19643732]
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0030177 ! positive regulation of Wnt signaling pathway

[Term]
id: GO:0038020
name: insulin receptor recycling
namespace: biological_process
def: "The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:3907718]
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0046628 ! positive regulation of insulin receptor signaling pathway

[Term]
id: GO:0038021
name: leptin receptor activity
namespace: molecular_function
def: "Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:9102398, Wikipedia:Leptin_receptor]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0038022
name: G protein-coupled olfactory receptor activity
namespace: molecular_function
def: "Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:sart, PMID:21041441]
synonym: "G-protein coupled odorant receptor activity" EXACT [GOC:bf, PMID:21041441]
synonym: "G-protein coupled olfactory receptor activity" EXACT []
synonym: "odorant receptor activity, G-protein coupled" NARROW [GOC:bf, PMID:21041441]
synonym: "olfactory receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0004984 ! olfactory receptor activity

[Term]
id: GO:0038023
name: signaling receptor activity
namespace: molecular_function
alt_id: GO:0004872
alt_id: GO:0019041
def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "receptor activity" BROAD []
synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf]
synonym: "signalling receptor activity" EXACT []
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0038024
name: cargo receptor activity
namespace: molecular_function
def: "Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles." [PMID:15239958, PMID:27903609]
comment: Notes: (1) For receptors binding a molecule but coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857'.
subset: goslim_drosophila
subset: goslim_generic
synonym: "endocytic receptor activity" NARROW [GOC:signaling, ISBN:0123645387, PMID:12671190]
synonym: "receptor activity" BROAD []
synonym: "receptor activity involved in receptor-mediated endocytosis" NARROW [GOC:bf]
synonym: "transport receptor activity" BROAD [GOC:signaling]
xref: Reactome:R-HSA-203716 "eNOS:Caveolin-1 complex binds to Nostrin"
xref: Reactome:R-HSA-3000103 "CUBN:AMN binds CBLIF:RCbl"
xref: Reactome:R-HSA-3000112 "CD320-mediated TCN2:RCbl uptake and delivery to lysosome"
xref: Reactome:R-HSA-3000122 "CD320 binds extracellular TCN2:RCbl"
xref: Reactome:R-HSA-3000137 "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome"
xref: Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D"
xref: Reactome:R-HSA-9759202 "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome"
xref: Reactome:R-HSA-9759209 "LRP2 binds extracellular TCN2:RCbl"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0038025
name: reelin receptor activity
namespace: molecular_function
def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215]
synonym: "reeler receptor activity" EXACT [PR:000013879]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0038026
name: reelin-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215]
synonym: "reeler-mediated signaling pathway" EXACT [GOC:bf, PR:000013879]
synonym: "reelin-mediated signal transduction pathway" EXACT [GOC:bf]
synonym: "reelin-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0038027
name: apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:16443932]
synonym: "apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0038028
name: obsolete insulin receptor signaling pathway via phosphatidylinositol 3-kinase
namespace: biological_process
def: "OBSOLETE. An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade." [GOC:bf, GOC:signaling, PMID:19322168, PMID:20696212]
comment: The reason for obsoletion is that insulin signaling activates the PI3K/PKB pathway (see Fig 3 in PMID:34274528), so this term is redundant with GO:0008286 insulin receptor signaling pathway.
synonym: "insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "insulin receptor signaling pathway via PI3K cascade" EXACT [GOC:bf]
synonym: "insulin receptor signaling via PI3K" EXACT [GOC:bf]
synonym: "insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0008286
consider: GO:0051897

[Term]
id: GO:0038029
name: obsolete epidermal growth factor receptor signaling pathway via MAPK cascade
namespace: biological_process
def: "OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal is transmitted via the MAPKKK cascade." [GOC:bf, GOC:signaling, PMID:21167805]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "EGFR signaling pathway via MAPKKK cascade" EXACT [GOC:bf]
synonym: "EGFR signaling via MAPKKK cascade" EXACT [GOC:bf]
synonym: "EGFR/MAPK signaling" EXACT [GOC:bf]
synonym: "epidermal growth factor receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling]
synonym: "epidermal growth factor receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0007173

[Term]
id: GO:0038030
name: obsolete non-canonical Wnt signaling pathway via MAPK cascade
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by a Wnt protein binding to a frizzled family receptor on the surface of a target cell, where the signal is passed on via the MAPKKK cascade." [GOC:BHF, GOC:signaling, GOC:vk, PMID:17720811]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "non-canonical Wnt receptor signaling pathway via MAPK cascade" EXACT []
synonym: "non-canonical Wnt receptor signaling pathway via MAPK signaling" EXACT [GOC:bf]
synonym: "non-canonical Wnt receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling]
synonym: "non-canonical Wnt receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf]
synonym: "non-canonical Wnt-activated signaling pathway via MAPK cascade" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0035567

[Term]
id: GO:0038031
name: obsolete non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade." [GOC:BHF, GPC:rl, PMID:19137009, PMID:20032469]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:bf]
synonym: "non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0035567
consider: GO:0046330

[Term]
id: GO:0038032
name: termination of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
synonym: "termination of G-protein coupled receptor signaling pathway" EXACT []
synonym: "termination of G-protein coupled receptor signalling pathway" EXACT [GOC:mah]
synonym: "termination of GPCR signaling pathway" EXACT [GOC:bf]
is_a: GO:0023021 ! termination of signal transduction
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway

[Term]
id: GO:0038033
name: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:bf, GOC:BHF, GOC:rl, PMID:21245381]
synonym: "positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway" EXACT [GOC:bf]
synonym: "vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis" RELATED [GOC:bf]
synonym: "VEGF-mediated chemotactic endothelial cell migration" BROAD [GOC:bf, PMID:21245381]
synonym: "VEGF-VEGFR-induced endothelial cell chemotaxis" EXACT [GOC:bf]
is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis

[Term]
id: GO:0038034
name: signal transduction in absence of ligand
namespace: biological_process
def: "The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679]
synonym: "addiction receptor signaling pathway" BROAD [PMID:15044679]
synonym: "basal signaling" NARROW [GOC:al]
synonym: "dependence receptor signaling pathway" BROAD [PMID:15044679]
synonym: "negative signal transduction" RELATED [PMID:15044679]
synonym: "non-classical signal transduction" BROAD [PMID:15044679]
synonym: "signal transduction in absence of agonist" EXACT [GOC:bf]
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0038035
name: ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway in which the receptor constitutively activates adenylate cyclase, without binding to an agonist." [PMID:12402500, PMID:17629961]
synonym: "basal G-protein coupled receptor signaling" NARROW [GOC:al]
synonym: "G protein-coupled receptor signaling in absence of ligand" BROAD []
synonym: "G-protein coupled receptor signaling in absence of agonist" BROAD [GOC:bf]
synonym: "G-protein coupled receptor signaling in absence of ligand" BROAD []
synonym: "G-protein coupled receptor signalling in absence of ligand" BROAD [GOC:mah]
is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway
is_a: GO:0038034 ! signal transduction in absence of ligand

[Term]
id: GO:0038036
name: sphingosine-1-phosphate receptor activity
namespace: molecular_function
def: "Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, PMID:12728273, Wikipedia:S1PR1]
synonym: "S1P receptor activity" EXACT [Wikipedia:Sphingosine_1-phosphate]
is_a: GO:0045125 ! bioactive lipid receptor activity

[Term]
id: GO:0038037
name: G protein-coupled receptor dimeric complex
namespace: cellular_component
def: "A protein complex that contains two G protein-coupled receptors." [GOC:al, GOC:bf, PMID:10713101]
synonym: "G-protein coupled receptor dimer" EXACT [GOC:bf]
synonym: "G-protein coupled receptor dimeric complex" EXACT []
synonym: "GPCR dimer" EXACT [GOC:bf]
is_a: GO:0097648 ! G protein-coupled receptor complex

[Term]
id: GO:0038038
name: G protein-coupled receptor homodimeric complex
namespace: cellular_component
def: "A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor." [GOC:al, GOC:bf, PMID:10713101, PMID:16670762]
synonym: "G-protein coupled receptor homodimer" EXACT [GOC:bf]
synonym: "G-protein coupled receptor homodimeric complex" EXACT []
synonym: "GPCR homodimer" EXACT [GOC:bf]
is_a: GO:0038037 ! G protein-coupled receptor dimeric complex

[Term]
id: GO:0038039
name: G protein-coupled receptor heterodimeric complex
namespace: cellular_component
def: "A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]
synonym: "G-protein coupled receptor heterodimer" EXACT [GOC:bf]
synonym: "G-protein coupled receptor heterodimeric complex" EXACT []
synonym: "GPCR heterodimer" EXACT [PMID:20150590]
is_a: GO:0038037 ! G protein-coupled receptor dimeric complex

[Term]
id: GO:0038040
name: obsolete cross-receptor activation within G-protein coupled receptor heterodimer
namespace: biological_process
def: "OBSOLETE. Activation of one protomer of a consequence of a G protein-coupled (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter." [GOC:al, GOC:bf, PMID:21063387]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0038041
name: cross-receptor inhibition within G protein-coupled receptor heterodimer
namespace: biological_process
def: "Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit." [GOC:al, GOC:bf, PMID:15979374]
subset: gocheck_obsoletion_candidate
synonym: "cross-receptor inhibition within G-protein coupled receptor heterodimer" EXACT []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
is_a: GO:2000272 ! negative regulation of signaling receptor activity

[Term]
id: GO:0038043
name: interleukin-5-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]
synonym: "IL-5-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-5-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038045
name: large latent transforming growth factor-beta complex
namespace: cellular_component
def: "A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors." [GOC:bf, PMID:2350783, PMID:8680476, PMID:9805445]
synonym: "large latent complex" EXACT []
synonym: "LLC" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0038046
name: G protein-coupled enkephalin receptor activity
namespace: molecular_function
def: "Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body." [GOC:bf, Wikipedia:Enkephalin]
synonym: "delta-opioid receptor activity" RELATED [GOC:bf]
synonym: "enkephalin receptor activity" BROAD []
is_a: GO:0004985 ! G protein-coupled opioid receptor activity
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0038047
name: morphine receptor activity
namespace: molecular_function
def: "Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf]
synonym: "mu-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! G protein-coupled opioid receptor activity

[Term]
id: GO:0038048
name: dynorphin receptor activity
namespace: molecular_function
def: "Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin." [GOC:bf, Wikipedia:Dynorphin]
synonym: "kappa-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! G protein-coupled opioid receptor activity
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0038053
name: obsolete transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Combining with estrogen and transmitting the signal to the transcriptional machinery by binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements." [GOC:signaling, PMID:17615392]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "estrogen nuclear receptor activity" BROAD [GOC:bf]
synonym: "estrogen-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0038054
name: G protein-coupled estrogen receptor activity
namespace: molecular_function
def: "Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:signaling, PMID:17379646, PMID:20960099]
synonym: "estrogen receptor activity" BROAD []
synonym: "G-protein coupled estrogen receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0038055
name: BMP secretion
namespace: biological_process
def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart]
synonym: "BMP protein secretion" EXACT [GOC:bf]
synonym: "bone morphogenetic protein secretion" EXACT [GOC:bf]
is_a: GO:0009306 ! protein secretion
is_a: GO:0023061 ! signal release

[Term]
id: GO:0038056
name: obsolete negative regulation of BMP signaling pathway by negative regulation of BMP secretion
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell." [GOC:bf, GOC:sart, PMID:21750037]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of BMP signaling pathway by negative regulation of bone morphogenetic protein secretion" EXACT [GOC:bf]
synonym: "negative regulation of BMP signalling pathway by negative regulation of BMP secretion" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0030514

[Term]
id: GO:0038057
name: TNFSF11 binding
namespace: molecular_function
def: "Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm]
synonym: "CD254 binding" EXACT [GOC:sl, PR:000002107]
synonym: "ODF binding" EXACT [GOC:sl, PR:000002107]
synonym: "OPGL binding" EXACT [GOC:sl, PR:000002107]
synonym: "osteoclast differentiation factor binding" EXACT [GOC:sl, PR:000002107]
synonym: "osteoprotegerin ligand binding" EXACT [GOC:sl, PR:000002107]
synonym: "RANKL binding" EXACT [GOC:sl, PR:000002107]
synonym: "receptor activator of nuclear factor kappa-B ligand binding" EXACT [GOC:sl, PR:000002107]
synonym: "TNF-related activation-induced cytokine binding" EXACT [GOC:sl, PR:000002107]
synonym: "TRANCE binding" EXACT [GOC:sl, PR:000002107]
synonym: "tumor necrosis factor (ligand) superfamily member 11 binding" EXACT [GOC:bf]
synonym: "tumor necrosis factor ligand superfamily member 11 binding" EXACT [PR:000002107]
synonym: "tumor necrosis factor superfamily member 11 binding" EXACT [GOC:bf]
is_a: GO:0043120 ! tumor necrosis factor binding

[Term]
id: GO:0038058
name: obsolete TNFSF11 receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm]
comment: This term aws obsoleted because it represents a gene product.
synonym: "RANKL receptor activity" EXACT [PR:000002107, Wikipedia:RANKL]
synonym: "tumor necrosis factor ligand superfamily member 11 receptor activity" EXACT [PR:000002107, Wikipedia:RANKL]
is_obsolete: true
replaced_by: GO:0005031

[Term]
id: GO:0038059
name: IKKalpha-IKKalpha complex
namespace: cellular_component
def: "A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits." [GOC:bf, PMID:18626576, PMID:21173796]
synonym: "IkappaB kinase alpha homodimer" EXACT [GOC:bf]
synonym: "IkappaB kinase-alpha homodimer" EXACT [PMID:21173796]
synonym: "IKKalpha homodimer" EXACT [GOC:bf]
synonym: "IKKalpha homodimeric complex" EXACT [GOC:bf]
synonym: "IKKalpha-IKKalpha protein complex" EXACT [GOC:bf]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0038060
name: nitric oxide-cGMP-mediated signaling
namespace: biological_process
def: "An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632]
synonym: "canonical nitric oxide signaling" EXACT [GOC:bf]
synonym: "classical nitric oxide signaling" EXACT [PMID:21549190]
synonym: "nitric oxide-cGMP-mediated signal transduction" EXACT []
synonym: "nitric oxide-cGMP-mediated signaling pathway" EXACT []
synonym: "nitric oxide-cGMP-mediated signalling pathway" EXACT [GOC:mah]
synonym: "NO-cGMP signaling pathway" EXACT [PMID:22019632]
is_a: GO:0007263 ! nitric oxide mediated signal transduction
is_a: GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0038061
name: non-canonical NF-kappaB signal transduction
namespace: biological_process
def: "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]
synonym: "NF-kappaB cascade" BROAD []
synonym: "NIK-IKK kinase cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]
synonym: "NIK-IKK signaling pathway" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]
synonym: "NIK-IKK-alpha cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]
synonym: "NIK/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "NIK/NF-kappaB signal transduction" EXACT [GOC:signaling]
synonym: "NIK/NF-kappaB signaling" EXACT []
synonym: "non-canonical NF-KB signaling" EXACT [PMID:21173796]
synonym: "noncanonical NF-kappaB signaling" EXACT [PMID:20501935]
synonym: "noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [PMID:20501935]
synonym: "p52-dependent NF-kappaB signaling" NARROW [PMID:18292232]
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0038062
name: protein tyrosine kinase collagen receptor activity
namespace: molecular_function
def: "Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:bf, GOC:uh, PMID:16626936, PMID:21568710]
synonym: "collagen RTK activity" EXACT [PMID:21568710]
synonym: "discoidin domain receptor" RELATED [PMID:16626936]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
is_a: GO:0038064 ! collagen receptor activity

[Term]
id: GO:0038063
name: collagen-activated tyrosine kinase receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:15888913, PMID:16626936]
synonym: "collagen-activated RTK signaling pathway" EXACT [PMID:21568710]
synonym: "collagen-activated tyrosine kinase receptor signalling pathway" EXACT [GOC:mah]
synonym: "DDR signaling pathway" NARROW [PMID:16626936]
synonym: "discoidin domain receptor signaling pathway" NARROW [PMID:16626936]
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
is_a: GO:0038065 ! collagen-activated signaling pathway

[Term]
id: GO:0038064
name: collagen receptor activity
namespace: molecular_function
def: "Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:uh, PMID:21568710]
synonym: "transmembrane collagen receptor activity" EXACT [PMID:21568710]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0038065
name: collagen-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:21568710]
synonym: "collagen-activated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0038066
name: p38MAPK cascade
namespace: biological_process
def: "A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:20811974, PMID:23125017, PMID:32794416]
synonym: "MAPK14 cascade" RELATED []
synonym: "osmosensory signaling MAPK cascade" NARROW []
synonym: "p38 cascade" EXACT [PMID:20811974]
synonym: "p38 MAPK cascade" EXACT [GOC:bf]
is_a: GO:0000165 ! MAPK cascade

[Term]
id: GO:0038067
name: obsolete MAP kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP kinase activity involved in cell wall biogenesis" NARROW []
synonym: "MAP kinase activity involved in cell wall integrity" RELATED [GOC:vw]
synonym: "MAPK activity involved in cell wall biogenesis" NARROW [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038068
name: obsolete MAP kinase kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP kinase kinase activity involved in cell wall biogenesis" NARROW [GOC:vw]
synonym: "MAP2K activity involved in cell wall integrity" EXACT [GOC:bf]
synonym: "MAPKK activity involved in cell wall integrity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0038069
name: obsolete MAP kinase phosphatase activity involved in regulation of cell wall biogenesis
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "Mpk1 phosphatase activity" NARROW [PMID:10523653]
synonym: "Slt2 phosphatase activity" NARROW [PMID:10523653]
is_obsolete: true

[Term]
id: GO:0038070
name: obsolete MAP kinase kinase kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP kinase kinase kinase activity involved in cell wall biogenesis" EXACT [GOC:vw]
synonym: "MAP3K activity involved in cell wall integrity" EXACT [GOC:bf]
synonym: "MAPKKK activity involved in cell wall integrity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0038071
name: obsolete MAP kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAPK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038072
name: obsolete MAP kinase kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP2K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
synonym: "MAPKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038073
name: obsolete MAP kinase kinase kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP3K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
synonym: "MAPKKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038074
name: obsolete MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAPK phosphatase activity involved in regulation of conjugation with cellular fusion" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0038075
name: obsolete MAP kinase activity involved in innate immune response
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
comment: This term was obsoleted because it should be represented as a GO-CAM model.
synonym: "MAPK activity involved in innate immune response" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038076
name: obsolete MAP kinase kinase activity involved in innate immune response
namespace: molecular_function
def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP2K activity involved in innate immune response" EXACT [GOC:signaling]
synonym: "MAPKK activity involved in innate immune response" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038077
name: obsolete MAP kinase kinase kinase activity involved in innate immune response
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP3K activity involved in innate immune response" EXACT [GOC:signaling]
synonym: "MAPKKK activity involved in innate immune response" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038078
name: obsolete MAP kinase phosphatase activity involved in regulation of innate immune response
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
comment: This term was obsoleted because it represents a biological process within the molecular function branch.
synonym: "MAPK phosphatase activity involved in regulation of innate immune response" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0038079
name: obsolete MAP kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAPK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038080
name: obsolete MAP kinase kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAP2K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
synonym: "MAPKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038081
name: obsolete MAP kinase kinase kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "MAP kinase kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAP3K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
synonym: "MAPKKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
is_obsolete: true

[Term]
id: GO:0038082
name: obsolete MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
synonym: "Hog1 phosphatase activity" NARROW [PMID:20880736]
synonym: "MAP kinase phosphatase activity involved in regulation of osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAPK phosphatase activity involved in regulation of osmosensory signaling pathway" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0038083
name: peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein." [PMID:10037737, PMID:10068444, PMID:10940390]
subset: gocheck_obsoletion_candidate
synonym: "receptor tyrosine kinase autophosphorylation" NARROW [PMID:20432069]
synonym: "RTK autophosphorylation" NARROW [PMID:20432069]
synonym: "tyrosine autophosphorylation" EXACT [PMID:16431914]
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
is_a: GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0038084
name: vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
synonym: "vascular endothelial growth factor signalling pathway" EXACT [GOC:bf]
synonym: "VEGF signaling" EXACT [GOC:bf]
synonym: "VEGF-activated signaling pathway" EXACT [GOC:bf]
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus

[Term]
id: GO:0038085
name: vascular endothelial growth factor binding
namespace: molecular_function
def: "Binding to a vascular endothelial growth factor." [PMID:17470632]
synonym: "VEGF binding" EXACT [GOC:bf]
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0038086
name: VEGF-activated platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A/PDGFR signaling" NARROW [PMID:17470632]
synonym: "VEGF-activated PDGFR signalling pathway" EXACT [GOC:bf]
synonym: "VEGF-activated platelet-derived growth factor receptor signalling pathway" EXACT [GOC:bf]
synonym: "VEGF/PDGFR signaling pathway" EXACT [PMID:17470632]
is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway
is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0038087
name: VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A/PDGFRalpha signaling" NARROW [PMID:17470632]
synonym: "VEGF-activated PDGFRalpha signalling pathway" EXACT [GOC:bf]
synonym: "VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:bf]
synonym: "VEGF/PDGFRalpha signaling pathway" EXACT [PMID:17470632]
is_a: GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0038088
name: VEGF-activated platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A/PDGFRbeta signaling" NARROW [PMID:17470632]
synonym: "VEGF-activated PDGFRbeta signalling pathway" EXACT [GOC:bf]
synonym: "VEGF-activated platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:bf]
synonym: "VEGF/PDGFRbeta signaling pathway" EXACT [PMID:17470632]
is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0038089
name: positive regulation of cell migration by vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling]
synonym: "positive regulation of cell migration by vascular endothelial growth factor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of cell migration by VEGF signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A-induced cell migration" NARROW [PMID:17470632]
synonym: "VEGF-induced cell migration" EXACT [GOC:bf]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway

[Term]
id: GO:0038090
name: positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PMID:17470632]
synonym: "positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of cell migration by VEGF/PDGFR signaling pathway" EXACT [PMID:17470632]
synonym: "VEGF/PDGFR-induced cell migration" EXACT [PMID:17470632]
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway
is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway

[Term]
id: GO:0038091
name: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation." [GOC:signaling, PMID:17470632]
synonym: "positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of cell proliferation by VEGF/PDGFR signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A-induced cell proliferation" NARROW [PMID:17470632]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0038092
name: nodal signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255]
synonym: "nodal signaling" EXACT [GOC:bf]
synonym: "nodal signalling pathway" EXACT [GOC:mah]
is_a: GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0038093
name: Fc receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor]
synonym: "Fc receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0038094
name: Fc-gamma receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:11244038]
synonym: "Fc-gamma receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0038093 ! Fc receptor signaling pathway

[Term]
id: GO:0038095
name: Fc-epsilon receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:12413516, PMID:15048725]
synonym: "Fc-epsilon receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0038093 ! Fc receptor signaling pathway

[Term]
id: GO:0038096
name: Fc-gamma receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GOC:phg, PMID:12488490, PMID:15466916]
synonym: "Fc gamma receptor-dependent phagocytosis" EXACT [PMID:18832707]
synonym: "Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:bf]
synonym: "Fcgamma receptor-mediated phagocytosis" EXACT [PMID:15466916]
synonym: "IgG-mediated phagocytosis" EXACT [PMID:1248849]
is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway
is_a: GO:0002433 ! immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
is_a: GO:0038094 ! Fc-gamma receptor signaling pathway

[Term]
id: GO:0038097
name: positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
namespace: biological_process
def: "An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:phg, PMID:12413516]
synonym: "Fc epsilon RI-dependent mast cell activation" EXACT [PMID:18377769]
synonym: "Fc epsilon RI-mediated mast cell activation" EXACT [PMID:17336609]
synonym: "positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway
is_a: GO:0033005 ! positive regulation of mast cell activation
is_a: GO:0038095 ! Fc-epsilon receptor signaling pathway

[Term]
id: GO:0038098
name: sequestering of BMP from receptor via BMP binding
namespace: biological_process
def: "Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014]
synonym: "extracellular sequestering of BMP" BROAD [GOC:bf]
synonym: "extracellular sequestering of bone morphogenetic protein" BROAD [GOC:bf]
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor

[Term]
id: GO:0038099
name: nodal receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals)." [GOC:bf, GOC:signaling, PMID:15062104]
synonym: "ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:bf]
synonym: "nodal receptor complex formation" EXACT [GOC:bf]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0038092 ! nodal signaling pathway

[Term]
id: GO:0038100
name: nodal binding
namespace: molecular_function
def: "Binding to a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0038101
name: sequestering of nodal from receptor via nodal binding
namespace: biological_process
def: "Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor." [GOC:signaling, PMID:14570583, PMID:15062104]
synonym: "binding to and sequestering nodal" EXACT [GOC:bf]
synonym: "extracellular regulation of nodal" BROAD [GOC:bf]
synonym: "nodal antagonist activity" BROAD [PMID:14570583]
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
relationship: part_of GO:1900108 ! negative regulation of nodal signaling pathway

[Term]
id: GO:0038102
name: activin receptor antagonist activity
namespace: molecular_function
def: "Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104]
comment: This term refers to inhibition of a member of the activin receptor family; activin receptors bind to multiple ligands including activin and nodal.
is_a: GO:0048019 ! receptor antagonist activity

[Term]
id: GO:0038103
name: obsolete activin receptor antagonist activity involved in negative regulation of nodal signaling pathway
namespace: molecular_function
def: "OBSOLETE. Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activin receptor antagonist activity involved in negative regulation of nodal signalling pathway" EXACT [GOC:mah]
synonym: "nodal antagonist activity" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0048018

[Term]
id: GO:0038104
name: nodal receptor complex
namespace: cellular_component
def: "A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell." [GOC:bf, GOC:signaling, PMID:11024047, PMID:15062104]
comment: Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex.
synonym: "ActRIIB.ALK4.EGF-CFC complex" NARROW [GOC:bf]
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0038105
name: sequestering of TGFbeta from receptor via TGFbeta binding
namespace: biological_process
def: "Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014]
comment: This term is for annotation of gene products that bind to TGFbeta. For gene products that tether the TGFbeta-containing latency complex to the extracellular matrix, but do not necessarily bind TGF-beta directly, consider instead annotating to 'sequestering of TGFbeta in extracellular matrix ; GO:0035583'.
synonym: "extracellular sequestering of TGFbeta" BROAD [GOC:bf]
synonym: "extracellular sequestering of transforming growth factor-beta" BROAD [GOC:bf]
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor

[Term]
id: GO:0038106
name: choriogonadotropin hormone binding
namespace: molecular_function
def: "Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit." [GOC:BHF, GOC:rl, Wikipedia:Human_chorionic_gonadotropin]
synonym: "chorionic gonadotrophin binding" EXACT [Wikipedia:Human_chorionic_gonadotropin]
synonym: "chorionic gonadotropin binding" EXACT [Wikipedia:Human_chorionic_gonadotropin]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0038107
name: obsolete nodal signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by a nodal protein binding of to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, GOC:vk, PMID:12857784, PMID:17287255, PMID:20413706]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0007368
consider: GO:0038092

[Term]
id: GO:0038108
name: negative regulation of appetite by leptin-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food." [GOC:BHF, GOC:vk, PMID:19150989]
synonym: "inhibition of appetite by leptin signaling" EXACT [GOC:bf]
synonym: "negative regulation of appetite by leptin-mediated signalling pathway" EXACT [GOC:mah]
synonym: "reduction of appetite by leptin-mediated signaling" EXACT [GOC:bf]
synonym: "suppression of appetite by leptin-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0032099 ! negative regulation of appetite
is_a: GO:0033210 ! leptin-mediated signaling pathway

[Term]
id: GO:0038109
name: Kit signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell." [GOC:nhn, GOC:signaling, PMID:16129412]
synonym: "Kit signalling pathway" EXACT [GOC:mah]
synonym: "SCF signaling pathway" EXACT [PMID:18787413]
synonym: "stem cell factor receptor signaling pathway" EXACT [PMID:16129412]
synonym: "stem cell factor signaling pathway" EXACT [PMID:16129412]
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0036216 ! cellular response to stem cell factor stimulus

[Term]
id: GO:0038110
name: interleukin-2-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-2-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-2-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071352 ! cellular response to interleukin-2

[Term]
id: GO:0038111
name: interleukin-7-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-7-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-7-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0098761 ! cellular response to interleukin-7

[Term]
id: GO:0038112
name: interleukin-8-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-8 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-8-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-8-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0098759 ! cellular response to interleukin-8

[Term]
id: GO:0038113
name: interleukin-9-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-9 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-9-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-9-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071355 ! cellular response to interleukin-9

[Term]
id: GO:0038114
name: interleukin-21-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-21 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-21-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-21-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0098757 ! cellular response to interleukin-21

[Term]
id: GO:0038115
name: chemokine (C-C motif) ligand 19 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
comment: The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'.
synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845]
synonym: "CCL19-mediated signaling pathway" EXACT [PMID:15059845]
synonym: "chemokine (C-C motif) ligand 19 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038116
name: chemokine (C-C motif) ligand 21 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
comment: The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203]
synonym: "CCL21-mediated signaling pathway" EXACT [PMID:15059845]
synonym: "chemokine (C-C motif) ligand 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038117
name: C-C motif chemokine 19 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845]
synonym: "CCL19 receptor activity" RELATED [PMID:15059845]
is_a: GO:0016493 ! C-C chemokine receptor activity

[Term]
id: GO:0038118
name: C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365]
comment: This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
synonym: "C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:mah]
synonym: "CCR7 signaling pathway" RELATED []
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038119
name: CCL19-activated CCR7 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
synonym: "CCL19-activated CCR7 signalling pathway" EXACT [GOC:mah]
is_a: GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway
is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway

[Term]
id: GO:0038120
name: CCL21-activated CCR7 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
synonym: "CCL21-activated CCR7 signalling pathway" EXACT [GOC:mah]
is_a: GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway
is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway

[Term]
id: GO:0038121
name: C-C motif chemokine 21 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845]
synonym: "CCL21 receptor activity" RELATED [PMID:15059845]
is_a: GO:0016493 ! C-C chemokine receptor activity

[Term]
id: GO:0038122
name: C-C motif chemokine 5 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling]
synonym: "CCL5 receptor activity" EXACT [PR:000002094]
synonym: "RANTES receptor activity" EXACT [GOC:bf]
synonym: "small inducible cytokine A5 receptor activity" EXACT [PR:000002094]
is_a: GO:0016493 ! C-C chemokine receptor activity

[Term]
id: GO:0038123
name: toll-like receptor TLR1:TLR2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding of a heterodimeric TLR1:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230]
synonym: "TLR2:TLR1 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor TLR1:TLR2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0038124
name: toll-like receptor TLR6:TLR2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230]
synonym: "TLR2:TLR6 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor TLR6:TLR2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0038127
name: ERBB signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Wikipedia:ErbB]
synonym: "EGF receptor family signaling pathway" EXACT [PMID:11597398]
synonym: "EGFR family signaling pathway" RELATED [PMID:11597398]
synonym: "ErbB signaling" EXACT [PMID:20933094, Wikipedia:ErbB]
synonym: "ERBB signalling pathway" EXACT [GOC:mah]
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0038128
name: ERBB2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914]
synonym: "ERBB2 signalling pathway" EXACT [GOC:mah]
synonym: "HER2 signaling pathway" EXACT [PR:000002082]
synonym: "NEU signaling" EXACT []
synonym: "receptor tyrosine-protein kinase erbB-2 signaling pathway" EXACT [PR:000002082]
is_a: GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:0038129
name: ERBB3 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914]
synonym: "ERBB3 signalling pathway" EXACT [GOC:mah]
synonym: "HER3 signaling pathway" EXACT [PR:000007159]
synonym: "receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [PR:000007159]
is_a: GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:0038130
name: ERBB4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914]
synonym: "ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER4 signaling pathway" EXACT [PR:000007160]
synonym: "receptor tyrosine-protein kinase erbB-4 signaling pathway" EXACT [PR:000007160]
is_a: GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:0038131
name: neuregulin receptor activity
namespace: molecular_function
def: "Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:16460914, PMID:20672328]
comment: Consider also annotating to 'ERBB3 signaling pathway ; GO:0038129' and/or 'ERBB4 signaling pathway ; GO:0038130'.
synonym: "NRG receptor activity" EXACT [PMID:16460914]
synonym: "NRG1 receptor activity" NARROW [PMID:16460914]
synonym: "NRG2 receptor activity" NARROW [PMID:16460914]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0038132
name: neuregulin binding
namespace: molecular_function
def: "Binding to a neuregulin, a member of the EGF family of growth factors." [GOC:bf, GOC:signaling]
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0038133
name: ERBB2-ERBB3 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission." [GOC:signaling, PMID:16460914]
synonym: "ERBB2-ERBB3 signalling pathway" EXACT [GOC:mah]
synonym: "HER2-HER3 signaling pathway" EXACT [PR:000002082, PR:000007159]
is_a: GO:0038128 ! ERBB2 signaling pathway
is_a: GO:0038129 ! ERBB3 signaling pathway

[Term]
id: GO:0038134
name: ERBB2-EGFR signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914]
synonym: "EGFR-HER2 signaling pathway" EXACT [PR:000002082, PR:000006933]
synonym: "ERBB2-EGFR signalling pathway" EXACT [GOC:mah]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
is_a: GO:0038128 ! ERBB2 signaling pathway

[Term]
id: GO:0038135
name: ERBB2-ERBB4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914]
synonym: "ERBB2-ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER2-HER4 signaling pathway" EXACT [PR:000002082, PR:000007160]
is_a: GO:0038128 ! ERBB2 signaling pathway
is_a: GO:0038130 ! ERBB4 signaling pathway

[Term]
id: GO:0038136
name: ERBB3-ERBB4 signaling pathway
namespace: biological_process
def: "The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914]
synonym: "ERBB3-ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER3-HER4 signaling pathway" EXACT [PR:000007159, PR:000007160]
is_a: GO:0038129 ! ERBB3 signaling pathway
is_a: GO:0038130 ! ERBB4 signaling pathway

[Term]
id: GO:0038137
name: ERBB4-EGFR signaling pathway
namespace: biological_process
def: "The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914]
synonym: "ERBB1-ERBB4 signaling pathway" EXACT [PR:000006933, PR:000007160]
synonym: "ERBB4-EGFR signalling pathway" EXACT [GOC:mah]
synonym: "HER1-HER4 signaling pathway" EXACT [PR:000006933, PR:000007160]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
is_a: GO:0038130 ! ERBB4 signaling pathway

[Term]
id: GO:0038138
name: ERBB4-ERBB4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914]
synonym: "ERBB4 homodimeric signaling pathway" EXACT [PMID:16460914]
synonym: "ERBB4-ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER4-HER4 signaling pathway" EXACT [PR:000007160]
is_a: GO:0038130 ! ERBB4 signaling pathway

[Term]
id: GO:0038139
name: ERBB4-EGFR complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1)." [GOC:signaling, PMID:16460914]
synonym: "EGFR-ERBB4 complex" EXACT [GOC:bf]
synonym: "ERBB4:EGFR heterodimer" EXACT []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0038140
name: ERBB4-ERBB3 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission." [GOC:signaling, PMID:16460914]
synonym: "ERBB3-ERBB4 complex" EXACT [GOC:bf]
synonym: "ERBB4:ERBB3 heterodimer" EXACT []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0038141
name: ERBB4-ERBB4 complex
namespace: cellular_component
def: "A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4)." [GOC:signaling, PMID:16460914]
synonym: "ERBB4 homodimer" EXACT []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0038142
name: EGFR:ERBB2 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, PMID:1973074]
synonym: "EGF:EGFR:ERBB2 complex" NARROW []
synonym: "EGFR:ERBB2 heterodimer" RELATED []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0038143
name: ERBB3:ERBB2 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3." [GOC:signaling, PMID:16460914, PMID:8665853]
synonym: "EGFR:ERBB2 heterodimer" NARROW []
synonym: "NRG1/2:ERBB3:ERBB2" NARROW []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0038144
name: ERBB4:ERBB2 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, PMID:16978839]
synonym: "ERBB4:ERBB2 heterodimer" NARROW []
synonym: "NRGs/EGFLs:ERBB4:ERBB2" NARROW []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0038145
name: macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor]
synonym: "M-CSF signaling pathway" EXACT [PMID:12138890]
synonym: "macrophage colony-stimulating factor signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus

[Term]
id: GO:0038146
name: chemokine (C-X-C motif) ligand 12 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:Stromal_cell-derived_factor-1]
synonym: "CXCL12 signaling pathway" EXACT [GOC:bf]
synonym: "CXCL12-activated CXCR7 signaling pathway" NARROW [GOC:bf]
synonym: "SDF1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066]
synonym: "stromal cell-derived factor-1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038147
name: C-X-C motif chemokine 12 receptor activity
namespace: molecular_function
def: "Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:22204316]
synonym: "CXCL12 receptor activity" EXACT [GOC:bf]
synonym: "CXCR4" NARROW [PMID:22204316]
synonym: "CXCR7" NARROW [PMID:22204316]
synonym: "SDF-1 receptor activity" RELATED [HGNC:10672, PR:000006066]
synonym: "stromal cell-derived factor-1 receptor activity" EXACT [HGNC:10672, PR:000006066]
is_a: GO:0016494 ! C-X-C chemokine receptor activity

[Term]
id: GO:0038148
name: chemokine (C-C motif) ligand 2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:CCL2]
synonym: "CCL2 signaling pathway" EXACT [GOC:bf]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038149
name: C-C motif chemokine 2 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling]
synonym: "CCL2 receptor activity" EXACT [GOC:bf]
is_a: GO:0016493 ! C-C chemokine receptor activity

[Term]
id: GO:0038150
name: C-C chemokine receptor CCR2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "C-C chemokine receptor type 2 signaling pathway" EXACT [PR:000001199]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038151
name: CCL2-activated CCR2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "CCL2/CCR2 signaling pathway" EXACT [GOC:bf]
is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway
is_a: GO:0038150 ! C-C chemokine receptor CCR2 signaling pathway

[Term]
id: GO:0038152
name: C-C chemokine receptor CCR4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "C-C chemokine receptor type 4 signaling pathway" EXACT [PR:000001200]
synonym: "chemokine receptor CCR4 signaling pathway" EXACT [GOC:bf]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038153
name: CCL2-activated CCR4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "CCL2/CCR4 signaling pathway" RELATED [GOC:bf]
is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway
is_a: GO:0038152 ! C-C chemokine receptor CCR4 signaling pathway

[Term]
id: GO:0038154
name: interleukin-11-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-11-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-11-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038155
name: interleukin-23-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-23 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-23-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-23-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038156
name: interleukin-3-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-3-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-3-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038157
name: granulocyte-macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors." [GOC:nhn, GOC:signaling, PMID:17027509]
synonym: "CSF2 signaling pathway" EXACT [PR:000005931]
synonym: "GM-CSF receptor signaling pathway" EXACT [GOC:nhn]
synonym: "GM-CSF signaling pathway" EXACT [PR:000005931]
synonym: "granulocyte-macrophage colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn]
synonym: "granulocyte-macrophage colony-stimulating factor signalling pathway" RELATED [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038158
name: granulocyte colony-stimulating factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R)." [GOC:nhn, GOC:signaling]
synonym: "CSF3 signaling pathway" EXACT [PR:000005932]
synonym: "G-CSF receptor signaling pathway" EXACT [GOC:nhn]
synonym: "G-CSF signaling pathway" EXACT [PR:000005932]
synonym: "granulocyte colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn]
synonym: "granulocyte colony-stimulating factor signalling pathway" RELATED [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038159
name: C-X-C chemokine receptor CXCR4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "CXCR4 signaling pathway" EXACT [PR:000001208]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038160
name: CXCL12-activated CXCR4 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn]
synonym: "CXCL12-activated CXCR4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0038146 ! chemokine (C-X-C motif) ligand 12 signaling pathway
is_a: GO:0038159 ! C-X-C chemokine receptor CXCR4 signaling pathway

[Term]
id: GO:0038161
name: prolactin signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429]
synonym: "PRL signaling pathway" EXACT [PMID:21664429, PR:000013246]
synonym: "prolactin-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038162
name: erythropoietin-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by erythropoietin (EPO) binding to the erythropoietin receptor (EPO-R) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:12489509]
synonym: "EPO-R signaling pathway" EXACT [PMID:12489509]
synonym: "erythropoietin receptor signaling pathway" EXACT [PMID:12489509]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0036018 ! cellular response to erythropoietin

[Term]
id: GO:0038163
name: thrombopoietin-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:19630807]
synonym: "THPO signaling pathway" EXACT [PR:000016318]
synonym: "THPO/MPL signaling pathway" EXACT [PMID:18371409]
synonym: "thrombopoietin receptor signaling pathway" EXACT [GOC:nhn, PR:000001939]
is_a: GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0038164
name: thrombopoietin receptor activity
namespace: molecular_function
def: "Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19630807]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0038165
name: oncostatin-M-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by oncostatin-M (OSM) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways." [GOC:nhn, GOC:signaling, PMID:10579456, PMID:12811586]
synonym: "oncostatin-M signaling pathway" EXACT [GOC:bf]
synonym: "OSM signaling pathway" EXACT [PMID:10579456, PR:000012059]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038166
name: angiotensin-activated signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]
synonym: "angiotensin II-mediated signaling pathway" EXACT [GOC:bf]
synonym: "angiotensin receptor signaling pathway" EXACT [GOC:bf, GOC:mtg_cardiac_conduct_nov11]
synonym: "angiotensin-mediated signaling pathway" RELATED []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
relationship: part_of GO:1904385 ! cellular response to angiotensin

[Term]
id: GO:0038167
name: obsolete epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal transmitted via the activation of the transcription factor NF-kappaB." [GOC:signaling, GOC:uh, PMID:21229383, PMID:21518868, PMID:22132240]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "EGFR signaling pathway via activation of NF-kappaB" EXACT [GOC:bf]
synonym: "epidermal growth factor receptor signalling pathway via positive regulation of NF-kappaB transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0007173

[Term]
id: GO:0038168
name: obsolete epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal transmitted via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB." [GOC:bf, PMID:22132240]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "EGFR signaling pathway via IKK-dependent activation of NF-kappaB" EXACT [GOC:bf]
synonym: "EGFR signaling pathway via IKK/NF-kappaB cascade" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0007173

[Term]
id: GO:0038169
name: somatostatin receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:jc, PMID:18006219, PMID:8769369]
comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'.
synonym: "SST receptor signaling pathway" EXACT [GOC:bf]
synonym: "SSTR signaling pathway" RELATED [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038170
name: somatostatin signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin]
synonym: "somatostatin signalling pathway" EXACT [GOC:bf]
synonym: "somatostatin-activated somatostatin receptor signaling pathway" EXACT [GOC:bf]
synonym: "somatostatin-mediated signaling pathway" EXACT [GOC:bf]
synonym: "somatotrophin release inhibiting factor signaling pathway" EXACT [Wikipedia:Somatostatin]
synonym: "SRIF signaling pathway" EXACT [Wikipedia:Somatostatin]
synonym: "SST signaling pathway" EXACT [Wikipedia:Somatostatin]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0038169 ! somatostatin receptor signaling pathway

[Term]
id: GO:0038171
name: cannabinoid signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid]
synonym: "cannabinoid receptor signaling pathway" EXACT [GOC:bf]
synonym: "cannabinoid-activated signaling pathway" EXACT [GOC:bf]
synonym: "cannabinoid-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038172
name: interleukin-33-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling]
synonym: "IL-33-mediated signaling pathway" EXACT [GOC:bf]
synonym: "IL33 signaling pathway" EXACT [PR:000001389]
synonym: "interleukin-33 signaling pathway" RELATED [GOC:jc]
synonym: "interleukin-33-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038173
name: interleukin-17A-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling]
synonym: "IL-17A-mediated signaling pathway" EXACT [GOC:bf]
synonym: "IL17A signaling pathway" EXACT [PR:000001138, Wikipedia:IL17A]
synonym: "interleukin-17A signaling pathway" RELATED [GOC:jc]
synonym: "interleukin-17A-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0038174
name: interleukin-17A receptor activity
namespace: molecular_function
def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling]
is_a: GO:0030368 ! interleukin-17 receptor activity

[Term]
id: GO:0038175
name: negative regulation of SREBP signaling pathway in response to increased oxygen levels
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels." [GOC:al, PMID:22017871]
synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen" RELATED [PMID:22017871]
synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels" EXACT [GOC:bf, GOC:vw]
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
relationship: part_of GO:0036295 ! cellular response to increased oxygen levels

[Term]
id: GO:0038176
name: positive regulation of SREBP signaling pathway in response to decreased oxygen levels
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels." [GOC:al, PMID:22017871]
synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen" RELATED [PMID:22017871]
synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels" EXACT [GOC:bf, GOC:vw]
is_a: GO:2000640 ! positive regulation of SREBP signaling pathway
relationship: part_of GO:0036294 ! cellular response to decreased oxygen levels

[Term]
id: GO:0038177
name: death receptor agonist activity
namespace: molecular_function
def: "Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor." [GOC:mtg_apoptosis, GOC:pr]
synonym: "death receptor activator activity" EXACT [GOC:pr]
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0038178
name: complement component C5a signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor." [GOC:jc, PMID:15313431, Wikipedia:Complement_component_5a]
synonym: "complement component C5a-induced signaling pathway" EXACT [GOC:jc]
is_a: GO:0002430 ! complement receptor mediated signaling pathway
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038179
name: neurotrophin signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin]
comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
synonym: "neurotrophin receptor signaling pathway" EXACT [PMID:22333586]
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0038180
name: nerve growth factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933]
comment: Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase.
synonym: "nerve growth factor signalling pathway" EXACT [GOC:bf]
synonym: "NGF signaling pathway" EXACT [PR:000011194, Wikipedia:Nerve_growth_factor]
xref: Wikipedia:Nerve_growth_factor
is_a: GO:0038179 ! neurotrophin signaling pathway
relationship: part_of GO:1990090 ! cellular response to nerve growth factor stimulus

[Term]
id: GO:0038181
name: obsolete bile acid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile." [GOC:bf, PMID:10334992, PMID:12718893]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true
consider: GO:0038182
consider: GO:0038186

[Term]
id: GO:0038182
name: G protein-coupled bile acid receptor activity
namespace: molecular_function
def: "Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [PMID:12524422, PMID:32480317, PMID:35415765, PMID:36409000]
synonym: "cell surface bile acid receptor" BROAD [GOC:bf]
synonym: "G-protein coupled bile acid receptor activity" EXACT []
synonym: "lithocholic acid receptor activity" BROAD []
synonym: "membrane bile acid receptor activity" BROAD [PMID:12419312]
xref: Wikipedia:G_protein-coupled_bile_acid_receptor
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0038183
name: bile acid signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:12016314, PMID:36409000]
comment: This term is not for direct annotation. Please use a more specific child: 'cell surface bile acid receptor signaling pathway' for GPCRs and 'intracellular bile acid receptor signaling pathway' for nuclear receptors.
subset: gocheck_do_not_annotate
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0038184
name: adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to a bile acid receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [PMID:12419312, PMID:19442546, PMID:36409000]
synonym: "cell surface bile acid receptor signaling pathway" BROAD []
synonym: "membrane bile acid receptor signaling pathway" RELATED [GOC:bf]
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway
is_a: GO:0038183 ! bile acid signaling pathway

[Term]
id: GO:0038185
name: nuclear receptor-mediated bile acid signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a bile acid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:10334992, PMID:36409000]
synonym: "BAR signaling pathway" RELATED [Wikipedia:Farnesoid_X_receptor]
synonym: "farnesoid X receptor signaling pathway" EXACT [Wikipedia:Farnesoid_X_receptor]
synonym: "FXR signaling pathway" EXACT [Wikipedia:Farnesoid_X_receptor]
synonym: "intracellular bile acid receptor signaling pathway" EXACT []
synonym: "nuclear bile acid receptor signaling pathway" RELATED []
is_a: GO:0038183 ! bile acid signaling pathway
is_a: GO:0141193 ! nuclear receptor-mediated signaling pathway

[Term]
id: GO:0038186
name: bile acid nuclear receptor activity
namespace: molecular_function
def: "A nuclear receptor activity regulated by a bile acid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [PMID:32480317, PMID:35415765, PMID:36409000]
synonym: "farnesoid X nuclear receptor activity" RELATED []
synonym: "farnesoid X receptor activity" RELATED [PMID:10334992]
synonym: "lithocholic acid receptor activity" BROAD []
xref: Reactome:R-HSA-5340195 "NR1H4 binds DCA, CDCA, LCHA"
is_a: GO:0004879 ! nuclear receptor activity

[Term]
id: GO:0038187
name: pattern recognition receptor activity
namespace: molecular_function
alt_id: GO:0008329
def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response." [GOC:ar, GOC:bf]
synonym: "macrophage receptor activity" RELATED []
synonym: "MAMP receptor activity" NARROW []
synonym: "microbe-associated molecular pattern receptor activity" NARROW []
synonym: "PAMP receptor activity" NARROW []
synonym: "pathogen associated molecular pattern receptor activity" NARROW []
synonym: "PRR" EXACT []
synonym: "PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor]
synonym: "signaling pattern recognition receptor activity" RELATED []
xref: Wikipedia:Pattern_recognition_receptor
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0038188
name: cholecystokinin signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:11181948]
synonym: "CCK signaling" EXACT [PMID:11181948, Wikipedia:Cholecystokinin]
synonym: "cholecystokinin receptor signaling pathway" RELATED [GOC:bf]
xref: Wikipedia:Cholecystokinin
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038189
name: neuropilin signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:12852851]
synonym: "Npn signaling" EXACT [PMID:12852851]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0038190
name: VEGF-activated neuropilin signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:rl, PMID:12852851]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-Npn-1 signaling" EXACT [PMID:12852851]
is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway
is_a: GO:0038189 ! neuropilin signaling pathway

[Term]
id: GO:0038191
name: neuropilin binding
namespace: molecular_function
def: "Binding to a member of the neuropilin family." [GOC:bf, PMID:23871893]
synonym: "neuropilin-binding" EXACT [PMID:12852851]
synonym: "Nrp binding" EXACT [PMID:23871893]
synonym: "Nrp ligand" NARROW [PMID:23871893]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0038192
name: gastric inhibitory peptide signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15955806]
synonym: "gastric inhibitory polypeptide receptor signaling pathway" EXACT [GOC:nhn]
synonym: "GIP signaling" EXACT [PMID:19251046]
synonym: "glucose-dependent insulinotropic polypeptide signaling" EXACT [PMID:19251046]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038193
name: thromboxane A2 signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by thromboxane A2 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15893915]
synonym: "TXA(2) receptor signaling" EXACT [PMID:15893915]
synonym: "TXA2 signaling" EXACT [PMID:15242977]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038194
name: thyroid-stimulating hormone signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:10809230]
synonym: "thyrotropin signaling pathway" EXACT [GOC:gap, PMID:10809230]
synonym: "TSH signaling pathway" EXACT [PMID:10809230]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0038195
name: urokinase plasminogen activator signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by urokinase plasminogen activator binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:9417082]
synonym: "uPA signaling pathway" EXACT [PMID:9417082]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0038196
name: type III interferon-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far." [GOC:signaling, PMID:32464097]
synonym: "interferon lambda signaling pathway" NARROW []
synonym: "type III interferon signaling pathway" EXACT []
synonym: "type III interferon-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0140888 ! interferon-mediated signaling pathway
relationship: part_of GO:0071358 ! cellular response to type III interferon

[Term]
id: GO:0038197
name: type I interferon receptor complex
namespace: cellular_component
def: "A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:cjm, GOC:signaling, PMID:17502368]
synonym: "interferon-alpha/beta receptor complex" NARROW [GOC:bf]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0038198
name: auxin receptor activity
namespace: molecular_function
def: "Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)." [GOC:signaling, PMID:15917797]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0038199
name: ethylene receptor activity
namespace: molecular_function
def: "Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity." [GOC:signaling, PMID:22467798, PMID:24012247]
synonym: "C2H4 receptor activity" EXACT [PMID:24012247]
synonym: "ethylene response sensor" RELATED [PMID:22467798]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0038200
name: ethylene receptor histidine kinase activity
namespace: molecular_function
def: "Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:signaling, PMID:22467798]
is_a: GO:0038199 ! ethylene receptor activity

[Term]
id: GO:0038201
name: TOR complex
namespace: cellular_component
def: "A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K." [Wikipedia:MTORC1, Wikipedia:MTORC2]
synonym: "mTOR complex" NARROW [Wikipedia:MTORC1]
synonym: "target of rapamycin complex" EXACT [GOC:bf]
synonym: "TOR signaling complex" EXACT [GOC:bf]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0038202
name: TORC1 signaling
namespace: biological_process
def: "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
synonym: "TORC1 signal transduction" EXACT [GOC:signaling]
is_a: GO:0031929 ! TOR signaling

[Term]
id: GO:0038203
name: TORC2 signaling
namespace: biological_process
def: "A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
synonym: "TORC2 signal transduction" EXACT [GOC:signaling]
is_a: GO:0031929 ! TOR signaling

[Term]
id: GO:0039003
name: pronephric field specification
namespace: biological_process
def: "The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney field specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072004 ! kidney field specification

[Term]
id: GO:0039004
name: specification of pronephric proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0039005 ! specification of pronephric tubule identity
is_a: GO:0072082 ! specification of proximal tubule identity
is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development
relationship: part_of GO:0039011 ! pronephric proximal tubule morphogenesis

[Term]
id: GO:0039005
name: specification of pronephric tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis

[Term]
id: GO:0039006
name: pronephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10]
synonym: "pronephric tubule formation" EXACT [GOC:mtg_kidney_jan10]
synonym: "pronephros tubule formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis
relationship: part_of GO:0072116 ! pronephros formation

[Term]
id: GO:0039007
name: pronephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0039019 ! pronephric nephron development
relationship: part_of GO:0072114 ! pronephros morphogenesis

[Term]
id: GO:0039008
name: pronephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0039007 ! pronephric nephron morphogenesis
relationship: part_of GO:0039020 ! pronephric nephron tubule development

[Term]
id: GO:0039009
name: rectal diverticulum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior." [GOC:mtg_kidney_jan10, PMID:10535314, PMID:18226983, XAO:0001015]
synonym: "pronephric rectal diverticulum development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039010
name: specification of pronephric distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0039005 ! specification of pronephric tubule identity
is_a: GO:0072084 ! specification of distal tubule identity
is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development
relationship: part_of GO:0039013 ! pronephric distal tubule morphogenesis

[Term]
id: GO:0039011
name: pronephric proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10]
synonym: "pronephros proximal tubule morphogenesis" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039008 ! pronephric nephron tubule morphogenesis
is_a: GO:0072158 ! proximal tubule morphogenesis
relationship: part_of GO:0035776 ! pronephric proximal tubule development

[Term]
id: GO:0039012
name: pronephric sinus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules." [GOC:mtg_kidney_jan10, PMID:10535314, XAO:0000385]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039013
name: pronephric distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10]
is_a: GO:0039008 ! pronephric nephron tubule morphogenesis
is_a: GO:0072156 ! distal tubule morphogenesis
relationship: part_of GO:0035777 ! pronephric distal tubule development

[Term]
id: GO:0039014
name: cell differentiation involved in pronephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "cell differentiation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039015
name: cell proliferation involved in pronephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10]
synonym: "cell proliferation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039016
name: cell-cell signaling involved in pronephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signaling involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in pronephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039017
name: pattern specification involved in pronephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039018
name: nephrostome development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity." [GOC:mtg_kidney_jan10, PMID:14686690, PMID:15647339, XAO:0000062]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039019
name: pronephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785]
is_a: GO:0072006 ! nephron development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039020
name: pronephric nephron tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0039019 ! pronephric nephron development

[Term]
id: GO:0039021
name: pronephric glomerulus development
namespace: biological_process
def: "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557]
comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus.
is_a: GO:0032835 ! glomerulus development
relationship: part_of GO:0039019 ! pronephric nephron development

[Term]
id: GO:0039022
name: pronephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150]
is_a: GO:0072176 ! nephric duct development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0039023
name: pronephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150]
is_a: GO:0072178 ! nephric duct morphogenesis
relationship: part_of GO:0039022 ! pronephric duct development
relationship: part_of GO:0072114 ! pronephros morphogenesis

[Term]
id: GO:0039501
name: obsolete suppression by virus of host type I interferon production
namespace: biological_process
def: "OBSOLETE. Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host type I interferon-mediated signaling pathway ; GO:0039502.
synonym: "negative regulation by virus of host type I interferon production" EXACT [GOC:bf]
synonym: "suppression by virus of host interferon type I production" EXACT [GOC:bf]
synonym: "suppression by virus of host type I IFN production" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0039502

[Term]
id: GO:0039502
name: symbiont-mediated suppression of host type I interferon-mediated signaling pathway
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, PMID:19802576, PMID:26712804, PMID:32464097, PMID:32733001, PMID:33097660]
synonym: "inhibition of host interferon signaling pathway by virus" RELATED [UniProtKB-KW:KW-1114]
synonym: "negative regulation by virus of host type I interferon-mediated signaling pathway" EXACT [GOC:bf]
synonym: "suppression by virus of host type I IFN-mediated signaling pathway" EXACT [GOC:bf]
synonym: "suppression by virus of host type I interferon-mediated signaling pathway" NARROW []
synonym: "suppression by virus of host type I interferon-mediated signalling pathway" EXACT [GOC:bf]
xref: VZ:883 "Inhibition of host IFN-mediated response initiation by virus"
is_a: GO:0140886 ! symbiont-mediated suppression of host interferon-mediated signaling pathway

[Term]
id: GO:0039503
name: obsolete suppression by virus of host innate immune response
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1090]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host innate immune response ; GO:0052170.
synonym: "inhibition of host innate immune response by virus" EXACT [UniProtKB-KW:KW-1090]
synonym: "negative regulation by virus of host innate immune response" EXACT [GOC:bf]
synonym: "negative regulation by virus of host innate immunity" EXACT [GOC:bf]
synonym: "suppression by virus of host innate immunity" EXACT [GOC:pg]
is_obsolete: true
replaced_by: GO:0052170

[Term]
id: GO:0039504
name: symbiont-mediated suppression of host adaptive immune response
namespace: biological_process
def: "A process by which a symbiont inhibits or disrupts the normal execution of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:bf, GOC:sp]
synonym: "inhibition of host adaptive immune response by virus" NARROW [UniProtKB-KW:KW-1080]
synonym: "negative regulation of host adaptive immune response" EXACT [GOC:bf]
synonym: "negative regulation of host adaptive immunity" EXACT [GOC:bf]
synonym: "suppression by virus of host adaptive immune response" NARROW []
synonym: "suppression of host acquired immune response" EXACT [ISBN:068340007X]
is_a: GO:0052562 ! symbiont-mediated suppression of host immune response

[Term]
id: GO:0039505
name: symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, GOC:bf, PMID:27832589, VZ:820]
synonym: "inhibition of host MHC class II molecule presentation by virus" NARROW [UniProtKB-KW:KW-1116]
synonym: "suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II" NARROW []
xref: VZ:820 "Inhibition of host MHC class II molecule presentation by virus"
is_a: GO:0039588 ! symbiont-mediated suppression of host antigen processing and presentation

[Term]
id: GO:0039506
name: obsolete modulation by virus of host molecular function
namespace: biological_process
def: "OBSOLETE. The process in which a virus effects a change in the function of a host protein via a direct interaction." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modification by virus of host protein function" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039507
name: obsolete suppression by virus of host molecular function
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation by virus of host protein function" EXACT [GOC:bf]
synonym: "down-regulation by virus of host protein function" EXACT [GOC:bf]
synonym: "inhibition by virus of host protein function" NARROW [GOC:bf]
synonym: "inhibition of host protein function" NARROW [GOC:bf]
synonym: "negative regulation by virus of host molecular function" EXACT [GOC:bf]
synonym: "negative regulation by virus of host protein function" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039508
name: obsolete suppression by virus of host receptor activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down-regulation by virus of host receptor activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host receptor activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host receptor activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host receptor activity" EXACT [GOC:bf]
synonym: "suppression by virus of host receptor function" EXACT [GOC:bf]
synonym: "viral inhibition of host receptor" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039509
name: obsolete suppression by virus of host pattern recognition receptor activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf]
synonym: "down-regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host pattern recognition receptor activity" NARROW [GOC:rf]
synonym: "negative regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf]
synonym: "suppression by virus of host pattern recognition receptor function" EXACT [GOC:bf]
synonym: "viral inhibition of host pattern recognition receptor activity" NARROW [GOC:bf]
is_obsolete: true
consider: GO:0039537

[Term]
id: GO:0039510
name: obsolete suppression by virus of host ATP-dependent RNA helicase activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down-regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host ATP-dependent RNA helicase activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039511
name: obsolete suppression by virus of host interferon receptor activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1091, VZ:843]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down-regulation by virus of host interferon receptor activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host interferon receptor activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host interferon receptor activity" NARROW [GOC:bf]
synonym: "inhibition of host interferon receptors by virus" EXACT [UniProtKB-KW:KW-1091]
synonym: "negative regulation by virus of host interferon receptor activity" EXACT [GOC:bf]
xref: VZ:843 "Inhibition of host interferon receptors by virus"
is_obsolete: true
consider: GO:0140886

[Term]
id: GO:0039512
name: obsolete suppression by virus of host protein tyrosine kinase activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
synonym: "down-regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host protein tyrosine kinase activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039513
name: obsolete suppression by virus of host catalytic activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down-regulation by virus of host enzyme activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host catalytic activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host catalytic activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host catalytic activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039514
name: symbiont-mediated suppression of host JAK-STAT cascade
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:20624917, PMID:22919663, PMID:27437422, PMID:29924996, PMID:31413201]
synonym: "disruption by virus of host JAK-STAT cascade" NARROW []
synonym: "down-regulation by virus of host JAK-STAT cascade" NARROW [GOC:bf]
synonym: "downregulation by virus of host JAK-STAT cascade" NARROW [GOC:bf]
synonym: "inhibition by virus of host JAK-STAT cascade" NARROW [GOC:bf]
synonym: "negative regulation by virus of host JAK-STAT cascade" NARROW [GOC:bf]
synonym: "suppression by virus of host JAK-STAT cascade" NARROW []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0039516
name: obsolete modulation by virus of host catalytic activity
namespace: biological_process
def: "OBSOLETE. The process in which a virus effects a change in host enzyme activity." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation of catalytic activity of host by virus" EXACT [GOC:bf]
synonym: "regulation by virus of host catalytic activity" EXACT [GOC:bf]
synonym: "regulation of host catalytic activity by virus" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039517
name: obsolete modulation by virus of host protein serine/threonine phosphatase activity
namespace: biological_process
def: "OBSOLETE. The process in which a virus effects a change in host protein serine/threonine phosphatase activity." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
synonym: "modulation by virus of protein serine/threonine phosphatase activity in host" EXACT [GOC:bf]
synonym: "regulation by virus of host protein serine/threonine phosphatase activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039518
name: obsolete suppression by virus of host cytokine activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down-regulation by virus of host cytokine activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host cytokine activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host cytokine activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host cytokine activity" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0052170

[Term]
id: GO:0039519
name: obsolete modulation by virus of host autophagy
namespace: biological_process
def: "OBSOLETE. Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp]
comment: This term was osboleted because it represents the same process as symbiont-mediated perturbation of host autophagy ; GO:0075071.
synonym: "regulation by virus of host autophagy" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0075071

[Term]
id: GO:0039520
name: symbiont-mediated activation of host autophagy
namespace: biological_process
alt_id: GO:0075044
def: "A process in which a symbiont initiates, promotes, or enhances the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. For example, some viruses are able to activate host autophagy as a cellular survival mechanism, hence delaying or inhibiting apoptosis." [GOC:bf, GOC:sp, VZ:846]
synonym: "activation of host autophagy by virus" EXACT [UniProtKB-KW:KW-1072]
synonym: "autophagy of host cells involved in interaction with symbiont" RELATED []
synonym: "induction by virus of host autophagy" NARROW []
synonym: "positive regulation by virus of host autophagy" BROAD [GOC:bf]
xref: VZ:846 "Activation of host autophagy by virus"
is_a: GO:0075071 ! symbiont-mediated perturbation of host autophagy

[Term]
id: GO:0039521
name: obsolete suppression by virus of host autophagy
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host autophagy ; GO:0140321.
synonym: "inhibition by virus of host autophagy" EXACT [GOC:bf]
synonym: "negative regulation by virus of host autophagy" BROAD [GOC:bf]
is_obsolete: true
replaced_by: GO:0140321

[Term]
id: GO:0039522
name: symbiont-mediated suppression of host mRNA export from nucleus
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:22334672]
synonym: "inhibition by virus of host mRNA nuclear export" NARROW [GOC:bf]
synonym: "inhibition of host mRNA nuclear export by virus" NARROW [UniProtKB-KW:KW-1099]
synonym: "negative regulation by virus of host mRNA nuclear export" BROAD [GOC:bf]
synonym: "suppression by virus of host mRNA export from nucleus" NARROW []
synonym: "suppression of host mRNA nuclear export by virus" NARROW []
xref: VZ:902 "Inhibition of host mRNA nuclear export by virus"
is_a: GO:0039657 ! symbiont-mediated suppression of host gene expression
is_a: GO:0052038 ! symbiont-mediated perturbation of host intracellular transport

[Term]
id: GO:0039523
name: symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the transcription of genes into mRNA in its host by directly inhibiting host RNA polymerase II activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:25233083, PMID:36144426]
synonym: "inhibition of host RNA polymerase II activity by virus" NARROW [GOC:bf]
synonym: "inhibition of host RNA polymerase II by virus" EXACT []
synonym: "negative regulation by virus of host RNA polymerase II activity" NARROW [GOC:bf]
synonym: "suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity" NARROW []
synonym: "suppression by virus of host RNA polymerase II activity" NARROW []
is_a: GO:0039653 ! symbiont-mediated suppression of host transcription

[Term]
id: GO:0039524
name: symbiont-mediated suppression of host mRNA processing
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts mRNA processing in its host. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:16571812, VZ:903]
synonym: "inhibition by virus of host mRNA processing" NARROW [GOC:bf]
synonym: "inhibition of host mRNA processing" EXACT []
synonym: "inhibition of host pre-mRNA processing by virus" NARROW [UniProtKB-KW:KW-1103, VZ:903]
synonym: "negative regulation of host mRNA processing" BROAD []
synonym: "suppression by virus of host mRNA processing" NARROW []
xref: VZ:903 "Inhibition of host pre-mRNA processing by virus"
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0039525
name: symbiont-mediated perturbation of host chromatin organization
namespace: biological_process
def: "A process in which a symbiont alters or subverts the organization of chromatin in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:11483770, PMID:16687403]
synonym: "modulation by virus of host chromatin organisation" EXACT [GOC:mah]
synonym: "modulation by virus of host chromatin organization" NARROW []
synonym: "modulation of host chromatin by virus" EXACT [VZ:899]
synonym: "modulation of host chromatin structure by virus" EXACT [GOC:bf]
synonym: "regulation by virus of host chromatin organization" RELATED [GOC:bf]
xref: VZ:899
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0039526
name: obsolete perturbation by virus of host apoptosis
namespace: biological_process
def: "OBSOLETE. A process in which a viral gene product affects host apoptosis, leading to a change in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:mtg_apoptosis, GOC:sp, PMID:12867651, PMID:15225638, PMID:16037790, UniProtKB-KW:KW-1119]
comment: This term has been obsoleted because it is too specific, consider symbiont-mediated perturbation of host apoptosis ; GO:0052150.
synonym: "modulation by virus of host apoptosis" EXACT []
synonym: "modulation by virus of host apoptotic process" EXACT []
synonym: "modulation of host cell apoptosis by virus" EXACT [UniProtKB-KW:KW-1119]
synonym: "perturbation by virus of host apoptotic process" EXACT []
synonym: "regulation by virus of host apoptosis" EXACT [GOC:bf]
xref: VZ:1581 "Apoptosis modulation"
is_obsolete: true
replaced_by: GO:0052150

[Term]
id: GO:0039527
name: symbiont-mediated suppression of host TRAF-mediated signal transduction
namespace: biological_process
alt_id: GO:0039547
def: "A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:20335533, PMID:27387501, PMID:28522607, PMID:31311877, PMID:33372174]
synonym: "disruption by virus of host TRAF-mediated signal transduction" NARROW []
synonym: "inhibition of host TRAF-mediated signal transduction by virus" EXACT [GOC:bf]
synonym: "inhibition of host TRAFs by virus" NARROW []
synonym: "negative regulation by virus of host TRAF-mediated signal transduction" BROAD [GOC:bf]
synonym: "suppression by virus of host TRAF activity" EXACT []
synonym: "suppression by virus of host TRAF-mediated signal transduction" EXACT []
synonym: "suppression by virus of host tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf]
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0039529
name: RIG-I signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines." [GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580, PMID:25579795]
synonym: "DDX58 signaling pathway" EXACT [HGNC:19102]
synonym: "retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102]
synonym: "RIG-I signalling pathway" EXACT [GOC:mah]
synonym: "RIG-I-like receptor (RLR) signaling pathway" EXACT []
synonym: "RIG-like helicase signaling pathway" EXACT []
synonym: "RIG-like receptor signaling pathway" EXACT []
synonym: "RLH signaling pathway" EXACT []
synonym: "RLR signaling pathway" EXACT []
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039530
name: MDA-5 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines." [GOC:bf, PMID:19620789, PMID:33087405]
synonym: "IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "MDA5 signaling pathway" NARROW [PMID:17328678]
synonym: "melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039531
name: regulation of cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl]
synonym: "regulation of cytosolic pattern recognition receptor signaling pathway" EXACT []
synonym: "regulation of MAV signaling" NARROW [GOC:bf, GOC:sp]
synonym: "regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway" NARROW []
synonym: "regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" NARROW [GOC:mah]
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039532
name: negative regulation of cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl]
synonym: "negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus" NARROW [GOC:bf]
synonym: "negative regulation of cytosolic pattern recognition receptor signaling pathway" EXACT []
synonym: "negative regulation of MAVS signaling" RELATED [GOC:bf]
synonym: "negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway" NARROW []
synonym: "negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" NARROW [GOC:mah]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039533
name: regulation of MDA-5 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl]
synonym: "regulation of IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "regulation of MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "regulation of MDA5 signaling pathway" EXACT [PMID:17328678]
synonym: "regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0039530 ! MDA-5 signaling pathway

[Term]
id: GO:0039534
name: negative regulation of MDA-5 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of the MDA-5 signaling pathway." [GOC:bf, GOC:jl]
synonym: "negative regulation of IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "negative regulation of MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of MDA5 signaling pathway" EXACT [PMID:17328678]
synonym: "negative regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0039533 ! regulation of MDA-5 signaling pathway
relationship: negatively_regulates GO:0039530 ! MDA-5 signaling pathway

[Term]
id: GO:0039535
name: regulation of RIG-I signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway." [GOC:bf, GOC:jl]
synonym: "regulation of DDX58 signaling pathway" EXACT [HGNC:19102]
synonym: "regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102]
synonym: "regulation of RIG-I signalling pathway" EXACT [GOC:mah]
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0039529 ! RIG-I signaling pathway

[Term]
id: GO:0039536
name: negative regulation of RIG-I signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway." [GOC:bf, GOC:jl]
synonym: "negative regulation of DDX58 signaling pathway" EXACT [HGNC:19102]
synonym: "negative regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102]
synonym: "negative regulation of RIG-I signalling pathway" EXACT [GOC:mah]
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0039535 ! regulation of RIG-I signaling pathway
relationship: negatively_regulates GO:0039529 ! RIG-I signaling pathway

[Term]
id: GO:0039537
name: symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl]
comment: Note that this term should be used when the symbiont directly inhibits a component of a host cytoplasmic receptor signaling pathway. In cases where the symbiont modifies its own molecules (proteins, DNA, RNA, lipids) to avoid recognition by the host, consider annotating to evasion of symbiont recognition by host pattern recognition receptor ; GO:0141141.
synonym: "suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf]
synonym: "suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RLR signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway" NARROW []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0052078 ! symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway

[Term]
id: GO:0039540
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity
namespace: biological_process
alt_id: GO:0039538
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19454348, PMID:26138103]
comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response initiated by host RIG-I, either by binding and inhibiting host RIG-I directly, or by interfering with other processes so that RIG-I is unable to carry out its normal function (e.g. by processing viral RNA so it cannot be recognized by RIG-I, or by promoting the degradation of RIG-I).
synonym: "inhibition by virus of host DDX58 activity" RELATED [GOC:sp]
synonym: "inhibition by virus of host RIG-I" RELATED []
synonym: "inhibition by virus of host RIG-I signaling" RELATED []
synonym: "inhibition of host DDX58/RIG-I by virus" EXACT []
synonym: "suppression by virus of host DDX58 signaling pathway" RELATED []
synonym: "suppression by virus of host RIG-I activity" RELATED []
synonym: "suppression by virus of host RIG-I signaling pathway" RELATED []
synonym: "suppression by virus of host RIG-I signalling pathway" EXACT []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity" NARROW []
synonym: "symbiont-mediated suppression of host RIG-I signaling pathway" RELATED []
xref: VZ:856
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039541
name: obsolete suppression by virus of host RIG-I via RIG-I binding
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by binding to RIG-I itself." [PMID:19193793, PMID:20007272, VZ:856]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition by virus of host DDX58:MAVS binding" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039542
name: obsolete suppression by virus of host RIG-I K63-linked ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity." [PMID:19454348, PMID:21890623]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition by virus of host DDX58 K63-linked ubiquitination" EXACT [GOC:bf]
synonym: "inhibition by virus of host RIG-I activity by inhibition of RIG-I ubiquitination" BROAD [GOC:bf]
synonym: "inhibition by virus of TRIM25-mediated ubiquitination of host RIG-I" EXACT [PMID:19454348]
is_obsolete: true

[Term]
id: GO:0039543
name: obsolete suppression by virus of host RIG-I activity by viral RNA 5' processing
namespace: biological_process
def: "OBSOLETE. The post-transcriptional removal by a virus of the 5' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5' triphosphates; removal by the virus of the 5'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition." [PMID:18446221, VZ:856]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "suppression by virus of host RIG-I activity by inhibition of RNA binding" NARROW [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039544
name: obsolete suppression by virus of host RIG-I activity by RIG-I proteolysis
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction." [PMID:19628239]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "cleavage of RIG-I by viral proteinase" EXACT [PMID:19628239]
synonym: "inhibition by virus of host RIG-I activity by RIG-I proteolysis" RELATED [VZ:856]
is_obsolete: true

[Term]
id: GO:0039545
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses." [PMID:17438296, PMID:22674996]
comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
synonym: "inhibition of host MAVS by virus" RELATED []
synonym: "suppression by virus of host MAVS activity" RELATED []
synonym: "suppression by virus of host mitochondrial antiviral-signaling protein" RELATED []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity" NARROW []
xref: VZ:704
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039546
name: obsolete suppression by virus of host MAVS activity by MAVS proteolysis
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling." [PMID:21436888, PMID:22238314]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "viral protease cleavage of MAVS" EXACT [PMID:22238314]
is_obsolete: true

[Term]
id: GO:0039548
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:21632562]
comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
synonym: "inhibition of host IRF3 by virus" RELATED []
synonym: "inhibition of IRF3-dependent antiviral response" RELATED [PMID:19125153]
synonym: "suppression by virus of host interferon regulatory factor 3" RELATED []
synonym: "suppression by virus of host IRF3 activity" RELATED []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity" NARROW []
xref: VZ:757
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039549
name: obsolete suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes." [PMID:11124948, PMID:12829834, PMID:20631144, PMID:9566918]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition of phosphorylation-induced activation of host IRF3" RELATED [PMID:11124948]
synonym: "inhibition of virus-induced IRF-3 phosphorylation" BROAD [PMID:12829834]
is_obsolete: true

[Term]
id: GO:0039550
name: obsolete suppression by virus of host IRF3 activity by inhibition of DNA binding
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites." [PMID:21632562]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition by virus of host IRF3-DNA binding" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039551
name: obsolete suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome." [VZ:757]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "promotion by virus of proteosome-dependent IRF3 degradation" EXACT [VZ:757]
is_obsolete: true

[Term]
id: GO:0039552
name: RIG-I binding
namespace: molecular_function
def: "Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA." [GOC:bf, PMID:21233210]
synonym: "DDX58 binding" EXACT [GOC:sp]
synonym: "DDX58/RIG-I binding" EXACT [GOC:sp]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0039553
name: obsolete suppression by virus of host chemokine activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1086, VZ:813]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down-regulation by virus of host chemokine activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host chemokine activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host chemokine activity" NARROW [GOC:bf]
synonym: "inhibition of host chemokines by virus" NARROW [UniProtKB-KW:KW-1086]
synonym: "negative regulation by virus of host chemokine activity" EXACT [GOC:bf]
xref: VZ:813 "Inhibition of host chemokines by virus"
is_obsolete: true
consider: GO:0052170

[Term]
id: GO:0039554
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
namespace: biological_process
alt_id: GO:0039539
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19019954, PMID:33727702]
synonym: "inhibition by virus of host MDA-5 signaling" RELATED []
synonym: "inhibition of host IFIH1/MDA5 by virus" RELATED []
synonym: "Inhibition of host MDA5 by virus" RELATED []
synonym: "suppression by virus of host IFIH1 signaling pathway" RELATED []
synonym: "suppression by virus of host MDA-5 activity" RELATED []
synonym: "suppression by virus of host MDA-5 signaling pathway" RELATED []
synonym: "suppression by virus of host MDA-5 signalling pathway" RELATED []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity" NARROW []
xref: VZ:603
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039555
name: obsolete suppression by virus of host MDA-5 activity via MDA-5 binding
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by binding to MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector." [PMID:19019954, VZ:603]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "suppression by virus of host MDA5 activity by MDA-5 binding" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039556
name: MDA-5 binding
namespace: molecular_function
def: "Binding to MDA-5, a cytoplasmic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA." [PMID:19019954]
synonym: "MDA5 binding" EXACT [GOC:bf]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0039557
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:11943871, PMID:16014964, PMID:19557165]
comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
synonym: "inhibition of host interferon regulatory factor-7 by virus" RELATED []
synonym: "inhibition of host IRF7 by virus" RELATED []
synonym: "suppression by virus of host interferon regulatory factor 7 activity" RELATED []
synonym: "suppression by virus of host IRF7 activity" RELATED []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity" NARROW []
xref: VZ:653
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039558
name: obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity." [PMID:18635538, PMID:19694547, VZ:653]
comment: The reason for obsoleting is that the term is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "promotion of IRF-7 SUMOylation" EXACT [PMID:19694547]
synonym: "suppression by virus of host interferon regulatory factor-7 activity by positive regulation of IRF7 sumoylation" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039559
name: obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome." [PMID:17301153, VZ:653]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "promotion by virus of proteosome-dependent IRF7 degradation" EXACT [VZ:653]
is_obsolete: true

[Term]
id: GO:0039560
name: symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. For example, viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes." [PMID:10388655, PMID:19109390]
comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
synonym: "disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity" NARROW []
synonym: "inhibition of host interferon regulatory factor-9 by virus" NARROW [GOC:bf]
synonym: "inhibition of host IRF9 by virus" NARROW []
synonym: "suppression by virus of host interferon regulatory factor 9 activity" NARROW []
synonym: "suppression by virus of host IRF9 activity" NARROW []
synonym: "suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity" NARROW []
xref: VZ:683
is_a: GO:0039514 ! symbiont-mediated suppression of host JAK-STAT cascade
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response

[Term]
id: GO:0039561
name: obsolete suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism." [PMID:19109390]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "suppression by virus of host IRF9 activity by nuclear localization of IRF9" RELATED [PMID:19109390]
synonym: "suppression of interferon signaling by nuclear accumulation of IRF9" RELATED [PMID:19109390]
is_obsolete: true

[Term]
id: GO:0039562
name: symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [GOC:bf]
comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
synonym: "disruption by virus of host JAK-STAT cascade via inhibition of STAT activity" NARROW []
synonym: "inhibition by virus of host STAT activity" NARROW [GOC:bf]
synonym: "suppression by virus of host JAK-STAT cascade via inhibition of STAT activity" EXACT []
synonym: "suppression by virus of host signal transducer and activator of transcription activity" EXACT [GOC:bf]
synonym: "suppression by virus of host STAT activity" EXACT []
is_a: GO:0039514 ! symbiont-mediated suppression of host JAK-STAT cascade

[Term]
id: GO:0039563
name: symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1)." [PMID:32699158]
comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
synonym: "disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity" NARROW []
synonym: "inhibition by virus of host STAT1 activity" NARROW [GOC:bf]
synonym: "inhibition of host STAT1 by virus" NARROW []
synonym: "suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity" NARROW []
synonym: "suppression by virus of host STAT1 activity" NARROW []
xref: VZ:282
is_a: GO:0039562 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity

[Term]
id: GO:0039564
name: symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2)." [PMID:32699158]
comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
synonym: "disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity" NARROW []
synonym: "inhibition by virus of host STAT2 activity" NARROW [GOC:bf]
synonym: "inhibition of host STAT2 by virus" NARROW []
synonym: "suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity" NARROW []
synonym: "suppression by virus of host STAT2 activity" NARROW []
xref: VZ:257
is_a: GO:0039562 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity

[Term]
id: GO:0039565
name: obsolete suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome." [PMID:15280488, PMID:16227264, VZ:282]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "promotion by virus of proteosome-dependent STAT1 degradation" EXACT []
synonym: "suppression by virus of host STAT1 activity by positive promotion of STAT1 proteasome-mediated degradation" EXACT [GOC:bf]
synonym: "targeting STAT1 for proteasome-mediated degradation" EXACT [VZ:282]
is_obsolete: true

[Term]
id: GO:0039566
name: obsolete suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by the removal of phosphoric residues from STAT1-O-phospho-tyrosine to form STAT1-tyrosine. For example, the viral phosphatase VH1 dephosphorylates STAT1 to reverse STAT1 activation." [PMID:11238845, PMID:21362620, VZ:282]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "suppression by virus of host STAT1 activity by peptidyl-tyrosine dephosphorylation of STAT1" EXACT [GOC:bf]
synonym: "viral tyrosine phosphatase activity involved in suppression of host STAT1" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039567
name: obsolete suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668, PMID:16254375, PMID:17287281]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "cytoplasmic sequestration of STAT1" BROAD [PMID:14557668]
synonym: "suppression by virus of host STAT1 activity by cytoplasmic sequestering of STAT1" EXACT [PMID:14557668]
is_obsolete: true

[Term]
id: GO:0039568
name: obsolete suppression by virus of host STAT1 activity by inhibition of DNA binding
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces STAT1-dependent gene transcription, by preventing STAT1 from binding to promoter sites in the nucleus." [PMID:17287281]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition of DNA binding of STAT1" EXACT [PMID:17287281]
synonym: "suppression by virus of host STAT1 activity by negative regulation of DNA binding" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039569
name: obsolete suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome." [PMID:11336548, PMID:17251292, PMID:19279106, VZ:257]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "promotion by virus of proteosome-dependent STAT2 degradation" EXACT []
synonym: "suppression by virus of host STAT2 activity by positive promotion of STAT2 proteasome-mediated degradation" EXACT [GOC:bf]
synonym: "targeting STAT2 for proteasome-mediated degradation" EXACT [VZ:257]
is_obsolete: true

[Term]
id: GO:0039570
name: obsolete suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "cytoplasmic sequestering of STAT2" EXACT [GOC:bf]
synonym: "cytoplasmic sequestration of STAT2" EXACT [PMID:14557668]
is_obsolete: true

[Term]
id: GO:0039571
name: obsolete suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation." [PMID:12804771]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition by virus of tyrosine phosphorylation of STAT1" RELATED [PMID:12804771]
is_obsolete: true

[Term]
id: GO:0039572
name: obsolete suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation." [PMID:12804771]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition by virus of tyrosine phosphorylation of STAT2" EXACT [PMID:12804771]
is_obsolete: true

[Term]
id: GO:0039573
name: obsolete suppression by virus of host complement activation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase." [PMID:21191012, PMID:7745740]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host complement activation ; GO:0042784.
synonym: "inhibition of host complement activation by virus" EXACT [GOC:bf]
synonym: "inhibition of host complement cascade by virus" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0039574
name: symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits." [PMID:16987978, PMID:19085955]
comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
synonym: "disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW []
synonym: "suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW []
synonym: "suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" NARROW []
synonym: "suppression by virus of host TYK2 activity" NARROW []
xref: VZ:720
is_a: GO:0039514 ! symbiont-mediated suppression of host JAK-STAT cascade
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response

[Term]
id: GO:0039575
name: obsolete suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2." [PMID:10523853, PMID:16987978, PMID:19254804]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "inhibition by virus of host TYK2 activation" BROAD [GOC:bf, PMID:19254804]
synonym: "inhibition by virus of host TYK2 phosphorylation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039576
name: symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
namespace: biological_process
alt_id: GO:0039515
def: "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host JAK1 (Janus Kinase 1)." [PMID:16188985]
comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
synonym: "disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity" NARROW []
synonym: "inhibition of host JAK activity by virus" NARROW [GOC:bf]
synonym: "negative regulation by virus of host JAK" NARROW [GOC:bf]
synonym: "negative regulation by virus of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf]
synonym: "suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity" NARROW []
synonym: "suppression by virus of host JAK1 activity" NARROW []
synonym: "suppression by virus of tyrosine phosphorylation of host STAT protein" NARROW []
synonym: "viral inhibition of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf]
xref: VZ:784 "Inhibition of host JAK1 by virus"
is_a: GO:0039514 ! symbiont-mediated suppression of host JAK-STAT cascade

[Term]
id: GO:0039577
name: obsolete suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1." [PMID:12620806]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
is_obsolete: true

[Term]
id: GO:0039578
name: obsolete suppression by virus of host JAK1 activity via JAK1 binding
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive." [PMID:9448289]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
is_obsolete: true

[Term]
id: GO:0039579
name: symbiont-mediated suppression of host ISG15-protein conjugation
namespace: biological_process
def: "Any process in which a symbiont inhibits or disrupts a host ubiquitin-like protein ISG15 conjugation to a substrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. For example, some viruses escape the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15, while the papain-like protease from the coronavirus cleaves ISG15 derivatives." [PMID:11157743, PMID:18078692, PMID:18604270, PMID:32845033]
synonym: "suppression by virus of host ISG15 activity" RELATED []
synonym: "suppression by virus of host ISG15-protein conjugation" NARROW []
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response

[Term]
id: GO:0039580
name: symbiont-mediated suppression of host PKR/eIFalpha signaling
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts host PKR (Protein Kinase regulated by RNA) signaling. PKR phosphorylates host targets such as the translation initiation factor eIF2alpha that inhibits protein synthesis as an antimicrobial response. Inhibition of host PKR signaling maintains the host ability to translate mRNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15207627]
synonym: "suppression by virus of host EIF2AK2 activity" NARROW []
synonym: "suppression by virus of host PKR activity" NARROW []
synonym: "suppression by virus of host PKR signaling" NARROW []
xref: VZ:554
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway
is_a: GO:0141154 ! symbiont-mediated suppression of host-directed shutoff of host translation

[Term]
id: GO:0039581
name: obsolete suppression by virus of host PKR activity via double-stranded RNA binding
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by binding to double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding." [PMID:7514679]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "suppression by virus of host PKR activity by binding to dsRNA" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039582
name: obsolete suppression by virus of host PKR activity by positive regulation of PKR nuclear localization
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha)." [PMID:16987971]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "suppression by virus of host PKR activity by nuclear sequestration of PKR" EXACT [GOC:bf]
synonym: "suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus" EXACT [GOC:bf]
synonym: "suppression by virus of host PKR activity by sequestering of PKR in nucleus" EXACT [PMID:16987971]
is_obsolete: true

[Term]
id: GO:0039583
name: obsolete suppression by virus of host PKR activity by positive regulation of PKR catabolic process
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes." [PMID:19751406]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "downregulation of PKR by degradation through proteosome" EXACT [PMID:19751406]
synonym: "promotion by virus of proteosome-dependent PKR degradation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039584
name: obsolete suppression by virus of host protein kinase activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity." [GOC:bf]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
is_obsolete: true

[Term]
id: GO:0039585
name: PKR/eIFalpha signaling
namespace: biological_process
def: "An intracellular signaling cassette that starts with activation and autophosphorylation of PKR (also known as EIF2AK2), which phosphorylates proteins including the translation initiation factor eIF2 to inhibit translation. PKR is activated by stress signals and during the antiviral response, activated by binding to viral double-stranded RNA (dsRNA) leading to inhibition of protein synthesis during viral infection." [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576]
synonym: "EIF2AK2 signal transduction" EXACT []
synonym: "EIF2AK2/PRK signaling" EXACT []
synonym: "PKR signal transduction" EXACT []
synonym: "PKR signaling pathway" EXACT [PMID:22102852]
synonym: "signaling through PKR" EXACT [GOC:bf]
is_a: GO:0140467 ! integrated stress response signaling

[Term]
id: GO:0039586
name: obsolete modulation by virus of host PP1 activity
namespace: biological_process
def: "OBSOLETE. The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response." [UniProtKB-KW:KW-1126, VZ:803]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
synonym: "modulation of host PP1 activity by virus" EXACT [UniProtKB-KW:KW-1126]
synonym: "regulation by virus of host PP1 activity" EXACT [GOC:bf]
xref: VZ:803 "Modulation of host PP1 activity by virus"
is_obsolete: true

[Term]
id: GO:0039587
name: symbiont-mediated-mediated suppression of host tetherin activity
namespace: biological_process
def: "Any process in which a symbiont stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects." [PMID:22493439]
synonym: "evasion of suppression of viral release by host via inhibition of host tetherin activity" NARROW []
synonym: "inhibition of host BST2/Tetherin by virus" EXACT []
synonym: "suppression by virus of host tetherin activity" EXACT []
xref: VZ:665
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0039588
name: symbiont-mediated suppression of host antigen processing and presentation
namespace: biological_process
def: "A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC protein complex." [VZ:815]
synonym: "suppression by virus of host antigen processing and presentation" NARROW []
xref: VZ:815 "Inhibition of host proteasome antigen processing by virus"
is_a: GO:0039504 ! symbiont-mediated suppression of host adaptive immune response

[Term]
id: GO:0039589
name: obsolete suppression by virus of host TAP complex
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response." [PMID:16691491, UniProtKB-KW:KW-1107, VZ:817]
comment: This term was obsoleted because this type of process is now represented by the actual function inhibited.
synonym: "inhibition of host TAP by virus" EXACT [UniProtKB-KW:KW-1107]
xref: VZ:817 "Inhibition of host TAP by virus"
is_obsolete: true
consider: GO:0039588

[Term]
id: GO:0039592
name: symbiont-mediated arrest of host cell cycle during G2/M transition
namespace: biological_process
def: "A process in which a symbiont interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase. The arrest in G2/M allows some viruses to replicate their genome before cells enter mitosis. Alternatively, it can inhibit the antiviral immune response by preventing the clonal expansion of infected lymphocytes." [PMID:10946289, PMID:12208959, PMID:9882364, VZ:876]
synonym: "host G2/M cell cycle arrest by virus" NARROW []
synonym: "perturbation by virus of G2/M transition of host mitotic cell cycle" NARROW []
synonym: "suppression by virus of G2/M transition of host mitotic cell cycle" NARROW []
xref: VZ:876 "Host G2/M cell cycle arrest by virus"
is_a: GO:0044071 ! symbiont-mediated perturbation of host cell cycle progression

[Term]
id: GO:0039593
name: symbiont-mediated perturbation of host exit from mitosis
namespace: biological_process
def: "A process in which a virus interferes with the host cell completing the M phase of the cell cycle." [VZ:877]
synonym: "inhibition of host mitotic exit by virus" EXACT [UniProtKB-KW:KW-1098, VZ:877]
synonym: "perturbation by virus of host exit from mitosis" NARROW []
synonym: "suppression by virus of host exit from mitosis" RELATED []
xref: VZ:877 "Inhibition of host mitotic exit by virus"
is_a: GO:0044071 ! symbiont-mediated perturbation of host cell cycle progression

[Term]
id: GO:0039594
name: obsolete endoribonuclease activity involved in viral induction of host mRNA catabolic process
namespace: molecular_function
def: "OBSOLETE. Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA." [GOC:bf, PMID:22046136]
comment: This term was obsoleted because it represents the same process as symbiont-mediated degradation of host mRNA ; GO:0039595.
is_obsolete: true
replaced_by: GO:0039595

[Term]
id: GO:0039595
name: symbiont-mediated degradation of host mRNA
namespace: biological_process
def: "The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA)." [PMID:12163576, PMID:16477041, PMID:17360652, PMID:22696660]
synonym: "induction by virus of catabolism of host mRNA" EXACT []
synonym: "induction by virus of host mRNA catabolic process" EXACT [GOC:bf]
synonym: "induction of host mRNA decay" EXACT [VZ:901]
synonym: "promotion of host mRNA degradation" EXACT []
synonym: "viral induction of host mRNA decay" EXACT [GOC:bf]
synonym: "virus-mediated mRNA decay" EXACT [VZ:901]
xref: VZ:901 "Virus-mediated host mRNA decay"
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0039596
name: obsolete modulation by virus of host protein dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein." [GOC:bf]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
is_obsolete: true

[Term]
id: GO:0039597
name: obsolete induction by virus of host endoribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity." [PMID:22174690]
comment: This term was obsoleted because it represents a molecular function.
synonym: "viral induction of host RNAse activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039598
name: obsolete induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "OBSOLETE. The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA) initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:sp]
comment: This term was made obsolete because it is unclear what role the viral protein is playing in this process. and there is insufficient evidence to use this term for annotation.
synonym: "induction by virus of host nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw]
synonym: "induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process" EXACT []
synonym: "virus-mediated host mRNA decay by hyperadenylation" NARROW [GOC:sp]
is_obsolete: true

[Term]
id: GO:0039602
name: symbiont-mediated suppression of host transcription initiation from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0039601
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:1316611]
synonym: "inhibition of host transcription initiation by virus" NARROW [GOC:bf]
synonym: "suppression by virus of host DNA-dependent transcription, initiation" NARROW []
synonym: "suppression by virus of host transcription initiation from RNA polymerase II promoter" NARROW []
xref: VZ:904 "Inhibition of host transcription initiation by virus"
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0039603
name: obsolete TBP-class protein binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter
namespace: molecular_function
def: "OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the class of TATA-binding proteins (TBP) in the host, including any of the TBP-related factors (TRFs), which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:11968006]
comment: The reason for obsoletion is that the term is too specific, and the paper referenced in the term should instead be annotated to GO:0039602 ; suppression by virus of host transcription initiation from RNA polymerase II promoter.
is_obsolete: true

[Term]
id: GO:0039604
name: symbiont-mediated suppression of host translation
namespace: biological_process
alt_id: GO:0039599
alt_id: GO:0039600
def: "A process in which a symbiont inhibits or disrupts the translation of host mRNA into protein, for example by cleavage of the host mRNAs. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22046136, PMID:22174690, PMID:32703221]
synonym: "host mRNA cleavage by viral endoribonuclease" NARROW [GOC:bf]
synonym: "host translation shutoff" EXACT []
synonym: "host translation shutoff by virus" NARROW [UniProtKB-KW:KW-1193, VZ:1579]
synonym: "suppression by virus of host translation" NARROW []
synonym: "viral host shutoff protein" NARROW []
synonym: "viral inhibition of cellular protein synthesis" NARROW [VZ:1579]
synonym: "viral shutoff of host protein synthesis" NARROW [PMID:8643618]
xref: VZ:1579 "Translation shutoff"
is_a: GO:0019057 ! symbiont-mediated perturbation of host translation

[Term]
id: GO:0039605
name: obsolete TFIIB-class transcription factor binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter
namespace: molecular_function
def: "OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the TFIIB-class of host transcription factors, which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:18768974]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
is_obsolete: true

[Term]
id: GO:0039606
name: symbiont-mediated suppression of host translation initiation
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts translation initiation in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf]
synonym: "suppression by virus of host translation initiation" NARROW []
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0039607
name: obsolete proteolysis by virus of host translation initiation factor
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of a host translation initiation factor by cleavage of its peptide bonds." [PMID:18572216]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
synonym: "cleavage of host translation initiation factor by viral protease" EXACT [GOC:bf]
synonym: "cleavage of host translation initiation factor by virus" RELATED [GOC:sp]
synonym: "proteolytic cleavage by virus of host translation initiation factor" EXACT [GOC:bf]
synonym: "suppression by virus of host translation initiation factor activity by proteolysis" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039608
name: obsolete suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein." [PMID:12239292, PMID:8643618]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
is_obsolete: true

[Term]
id: GO:0039611
name: obsolete suppression by virus of host translation initiation factor activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor." [GOC:bf, UniProtKB-KW:KW-1075]
comment: This term has been obsoleted because it represents a molecular function as a biological process.
synonym: "inactivation of eIF2 activity" NARROW [PMID:12239292]
synonym: "inhibition of activity of host translation initiation factor" EXACT [PMID:12239292]
synonym: "Inhibition of host translation factors by virus" BROAD [UniProtKB-KW:KW-1075]
synonym: "suppression by virus of host EIF-4E activity" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0039606

[Term]
id: GO:0039612
name: obsolete modulation by virus of host protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
is_obsolete: true

[Term]
id: GO:0039613
name: obsolete suppression by virus of host protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
synonym: "viral inhibition of host protein phosphorylation" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0039614
name: obsolete induction by virus of host protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
is_obsolete: true

[Term]
id: GO:0039615
name: T=1 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres." [VZ:1057]
xref: VZ:1057 "T=1 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039616
name: T=2 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers." [VZ:838]
comment: The T=2 symmetry is an non-official appellation; strictly speaking the capsid has a T=1 symmetry with each unit composed of a homodimer.
xref: VZ:838 "T=2 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039617
name: T=3 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [VZ:806]
xref: VZ:806 "T=3 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039618
name: T=pseudo3 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [VZ:809]
comment: T=pseudo3 capsids are not T=3 symmetry as described by Caspar and Klug (PMID:14019094) because the basic unit is composed of three different proteins. Since the three subunits are morphologically very similar, the structure is therefore a pseudo T=3.
xref: VZ:809 "T=pseudo3 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039619
name: T=4 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres." [VZ:808]
xref: VZ:808 "T=4 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039620
name: T=7 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres." [VZ:804]
comment: Spherical viruses with T numbers greater than or equal to 7 are skewed. They are therefore described as either right-handed (dextro) or left-handed (laevo).
xref: VZ:804 "T=7 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039621
name: T=13 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres." [VZ:260]
xref: VZ:260 "T=13 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039622
name: T=16 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres." [VZ:807]
xref: VZ:807 "T=16 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039623
name: T=25 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres." [VZ:810]
xref: VZ:810 "T=25 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039624
name: viral outer capsid
namespace: cellular_component
def: "The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1152]
synonym: "outer capsid" EXACT [GOC:bf]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039625
name: viral inner capsid
namespace: cellular_component
def: "The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1153]
synonym: "inner capsid" EXACT [GOC:bf]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039626
name: viral intermediate capsid
namespace: cellular_component
def: "The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions." [UniProtKB-KW:KW-1154]
synonym: "intermediate capsid" EXACT [GOC:bf]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039627
name: T=147 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins." [GOC:plm, UniProtKB-KW:KW-0167]
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039628
name: T=169 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins." [GOC:plm, VZ:10117]
synonym: "T=169 icosahedral capsid" EXACT [GOC:bf]
xref: VZ:10117 "T=169 icosahedral capsid"
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039629
name: T=219 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1151]
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039630
name: RNA translocase activity
namespace: molecular_function
def: "Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis." [GOC:bm, PMID:22713318]
comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.
is_a: GO:0008186 ! ATP-dependent activity, acting on RNA

[Term]
id: GO:0039631
name: obsolete DNA translocase activity involved in viral DNA genome packaging
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid." [GOC:bm, PMID:17501915]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "viral DNA packaging activity" RELATED [GOC:bm]
synonym: "viral DNA packaging motor activity" RELATED [PMID:17501915]
is_obsolete: true

[Term]
id: GO:0039632
name: obsolete RNA translocase activity involved in viral RNA genome packaging
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid." [GOC:bm, PMID:22297533]
comment: This term was obsoleted because it represents both a molecular function and a biological process.
synonym: "RNA packaging ATPase activity" EXACT [PMID:22297533]
synonym: "viral RNA packaging activity" RELATED [GOC:bm]
is_obsolete: true
replaced_by: GO:0039630

[Term]
id: GO:0039633
name: obsolete killing by virus of host cell
namespace: biological_process
def: "OBSOLETE. Any process mediated by a virus that results in the death of a cell in the host organism." [GOC:bf, GOC:bm, GOC:jl]
comment: This term was obsoleted because it was redundant with other terms.
synonym: "killing by phage of host cells" NARROW [GOC:bm]
synonym: "killing by virus of host cells" EXACT []
is_obsolete: true

[Term]
id: GO:0039634
name: killing by virus of host cell during superinfection exclusion
namespace: biological_process
def: "The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bf, GOC:bm, GOC:jl, PMID:22398285]
synonym: "killing by virus of host cells during superinfection exclusion" EXACT []
synonym: "killing by virus of host cells involved in superinfection exclusion" EXACT [GOC:bf]
synonym: "Rex exclusion" NARROW []
is_a: GO:0001907 ! symbiont-mediated killing of host cell
is_a: GO:0009615 ! response to virus

[Term]
id: GO:0039635
name: symbiont-mediated suppression of host peptidoglycan biosynthetic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm, GOC:jl]
synonym: "suppression by virus of host peptidoglycan biosynthetic process" NARROW []
synonym: "viral inhibition of host peptidoglycan biosynthesis" RELATED [GOC:bf]
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0039636
name: symbiont-mediated suppression of host cell wall biogenesis
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts." [GOC:bf, GOC:bm, GOC:jl]
synonym: "suppression by virus of host cell wall biogenesis" NARROW []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0039637
name: obsolete catabolism by virus of host DNA
namespace: biological_process
def: "OBSOLETE. The breakdown of host DNA, deoxyribonucleic acid, by a virus." [GOC:bf, GOC:bm, GOC:jl]
comment: This term was obsoleted because it was an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0039638
name: lipopolysaccharide-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface." [GOC:bf, GOC:bm, PMID:12837775]
synonym: "lipopolysaccharide binding involved in viral attachment to host cell" EXACT [GOC:bf, GOC:bm]
synonym: "LPS binding involved in viral attachment to host cell" EXACT [GOC:bf]
synonym: "virion attachment, binding to host lipopolysaccharide" EXACT [GOC:bf, GOC:jl]
is_a: GO:0019062 ! virion attachment to host cell

[Term]
id: GO:0039639
name: suppression by virus of host cell lysis in response to superinfection
namespace: biological_process
def: "The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bm, GOC:jl, PMID:22389108, PMID:9560373]
synonym: "lysis inhibition" BROAD [GOC:bm, PMID:22389108]
synonym: "suppression by virus of host cell lysis in response to superinfecting virus" EXACT [GOC:bf]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0039640
name: viral release via suppression of host peptidoglycan biosynthetic process
namespace: biological_process
def: "The dissemination of mature viral particles from a host cell, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm, PMID:28894177]
synonym: "cytolysis by virus via suppression of host peptidoglycan biosynthetic process" RELATED []
synonym: "viral exit by cytolysis via suppression of host peptidoglycan biosynthetic process" EXACT []
synonym: "viral release by cytolysis via suppression of host peptidoglycan biosynthetic process" EXACT []
is_a: GO:0044659 ! viral release from host cell by cytolysis

[Term]
id: GO:0039641
name: viral inner membrane
namespace: cellular_component
def: "The lipid bilayer of a virion contained inside the protein capsid." [GOC:bm, PMID:15331712]
synonym: "virion inner membrane" EXACT [GOC:bf, GOC:bm, GOC:jl]
is_a: GO:0036338 ! viral membrane

[Term]
id: GO:0039642
name: virion nucleoid
namespace: cellular_component
def: "The region of a virion in which the nucleic acid is confined." [GOC:bm, PMID:14291596]
is_a: GO:0044423 ! virion component

[Term]
id: GO:0039643
name: host cell viral nucleoid
namespace: cellular_component
def: "The region of a host cell that contains the viral genome." [GOC:bf, GOC:bm, GOC:jl]
comment: To annotate the region of the complete virus particle in which the viral genome is contained, instead use 'virion nucleoid ; GO:0039642'.
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0039644
name: obsolete suppression by virus of host NF-kappaB cascade
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces a host NF-kappaB cascade." [PMID:10920188, PMID:25275128]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host canonical NF-kappaB cascade ; GO:0085034.
synonym: "inhibition of host NF-kappa-B by virus" EXACT []
synonym: "suppression by virus of host NF-kappaB transcription factor activity" RELATED []
is_obsolete: true
replaced_by: GO:0085034

[Term]
id: GO:0039645
name: symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
namespace: biological_process
def: "A process in which a symbiont interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24501404, VZ:880]
synonym: "G1/S host cell cycle checkpoint dysregulation by virus" EXACT [VZ:880]
synonym: "modulation by virus of host G1/S transition checkpoint" RELATED []
synonym: "perturbation by virus of host G1/S transition checkpoint" NARROW []
xref: VZ:880 "G1/S host cell cycle checkpoint dysregulation by virus"
is_a: GO:0044071 ! symbiont-mediated perturbation of host cell cycle progression

[Term]
id: GO:0039646
name: symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint
namespace: biological_process
def: "A process in which a symbiont interferes with the normal execution of the host cell G0/G1 transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction. Some viruses benefit from keeping cells in resting state (G0), while others favor entry through G1 and subsequent cell division to replicate more efficiently." [VZ:880]
synonym: "G0/G1 host cell cycle checkpoint dysregulation by virus" NARROW [UniProtKB-KW:KW-1077, VZ:881]
synonym: "modulation by virus of host G0/G1 transition checkpoint" NARROW []
synonym: "perturbation by virus of host G0/G1 transition checkpoint" NARROW []
xref: VZ:881 "G0/G1 host cell cycle checkpoint dysregulation by virus"
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0039647
name: obsolete suppression by virus of host poly(A)-binding protein activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation." [UniProtKB-KW:KW-1101]
comment: This term was obsoleted because it represents a molecular function.
synonym: "inhibition of host poly(A)-binding protein by virus" EXACT [UniProtKB-KW:KW-1101]
synonym: "suppression by virus of host PABP activity" EXACT [Wikipedia:Poly(A)-binding_protein]
is_obsolete: true
consider: GO:0039604

[Term]
id: GO:0039648
name: symbiont-mediated perturbation of host ubiquitin-like protein modification
namespace: biological_process
def: "A process by which a symbiont alters ubiquitin-like protein modification of target proteins of either host or symbiont proteins. This includes ubiquitination, SUMOylation, NEDDylation, and ISG15ylation. The ubiquitination status of a protein  affects whether it is targeted to the proteasome for degradation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:25166298, PMID:26483404, PMID:26712804]
synonym: "modulation by symbiont of host protein ubiquitination" EXACT []
synonym: "modulation of host ubiquitin pathway by virus" NARROW []
synonym: "symbiont-mediated perturbation of host protein SUMOlyation" NARROW []
synonym: "symbiont-mediated perturbation of host protein ubiquitination" NARROW []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0039649
name: obsolete modulation by virus of host ubiquitin-protein ligase activity
namespace: biological_process
def: "OBSOLETE. The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [UniProtKB-KW:KW-1123]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation of host E3 ubiquitin ligases by virus" NARROW [UniProtKB-KW:KW-1123]
is_obsolete: true
replaced_by: GO:0039648

[Term]
id: GO:0039652
name: obsolete induction by virus of host NF-kappaB cascade
namespace: biological_process
def: "OBSOLETE. A process in which a virus initiates, promotes, or enhances an NF-kappaB signaling cascade in its host organism." [PMID:11907233, PMID:7845680]
comment: This term was obsoleted because it represents the same process as symbiont-mediated activation of host NF-kappaB signal transduction ; GO:0085033.
synonym: "activation by virus of host NF-kappaB transcription factor activity" RELATED []
is_obsolete: true
replaced_by: GO:0085033

[Term]
id: GO:0039653
name: symbiont-mediated suppression of host transcription
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts transcription of genes into mRNA in its host. For example, symbiont proteins can interfere with host RNA polymerase or with transcription factors. The host is defined as the larger of the organisms involved in a symbiotic interaction." [VZ:1577]
synonym: "host transcription shut-off" EXACT []
synonym: "host transcription shutoff by virus" NARROW [UniProtKB-KW:KW-1191, VZ:1577]
synonym: "suppression by virus of host DNA-dependent transcription" NARROW [GOC:bf]
synonym: "suppression by virus of host transcription" NARROW []
xref: VZ:1577 "Host transcription shutoff by virus"
is_a: GO:0052026 ! symbiont-mediated perturbation of host transcription

[Term]
id: GO:0039654
name: fusion of virus membrane with host endosome membrane
namespace: biological_process
alt_id: GO:0075501
alt_id: GO:0075517
def: "Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell." [GOC:bf, UniProtKB-KW:KW-1170, VZ:992]
synonym: "fusion of virus membrane with host endosomal membrane" EXACT [UniProtKB-KW:KW-1170, VZ:992]
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW []
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW []
synonym: "viral entry into host cell via endocytosis followed by membrane fusion with host endosome" RELATED [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane" NARROW []
synonym: "viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane" NARROW []
xref: VZ:992 "Fusion of virus membrane with host endosomal membrane"
is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell

[Term]
id: GO:0039655
name: obsolete transport of virus in host, cell to cell via plasmodesmata
namespace: biological_process
def: "OBSOLETE. The transport of a virus between adjacent cells in a multicellular organism using plasmodesmata. Plasmodesma is a fine cytoplasmic channel found in all higher plants, which connects the cytoplasm of one cell to that of an adjacent cell." [UniProtKB-KW:KW-0916, VZ:1018]
synonym: "spread of virus in host, cell to cell via plasmodesmata" RELATED [GOC:bf, GOC:jl]
synonym: "viral movement protein" RELATED [VZ:1018]
xref: VZ:1018 "Viral movement protein"
is_obsolete: true

[Term]
id: GO:0039656
name: symbiont-mediated perturbation of host gene expression
namespace: biological_process
def: "A process in which a symbiont alters or subverts the normal execution of host gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf]
synonym: "modulation by virus of host gene expression" NARROW []
synonym: "regulation by virus of host gene expression" RELATED [GOC:bf]
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0039657
name: symbiont-mediated suppression of host gene expression
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts expression of genes in its host. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The host is defined as the larger of the organisms involved in a symbiotic interaction." [VZ:1582]
synonym: "host gene expression shutoff" EXACT []
synonym: "host gene expression shutoff by virus" NARROW [UniProtKB-KW:KW-1190, VZ:1582]
synonym: "suppression by virus of host gene expression" NARROW []
xref: VZ:1582 "Host gene expression shutoff by virus"
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0039658
name: TBK1-IKKE-DDX3 complex
namespace: cellular_component
def: "A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3." [PMID:18636090, VZ:719]
synonym: "TBK1-IKBKE-DDX3 complex" EXACT [VZ:719]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0039659
name: obsolete suppression by virus of host TBK1-IKBKE-DDX3 complex activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TBK1-IKBKE-DDX3 complex." [VZ:719]
comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. See also: suppression by virus of host TBK1 activity; GO:0039723, and suppression by virus of host IKBKE activity; GO:0039724.
synonym: "inhibition of host TBK1-IKBKE-DDX3 complex by virus" EXACT [VZ:719]
synonym: "suppression by virus of host TBK1-IKKE-DDX3 complex activity" EXACT []
xref: VZ:719 "Inhibition of host TBK1-IKBKE-DDX3 complex by virus"
is_obsolete: true

[Term]
id: GO:0039660
name: structural constituent of virion
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a virion." [GOC:bf, GOC:jl]
synonym: "viral matrix protein" NARROW [UniProtKB-KW:KW-0468]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0039661
name: host organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell." [GOC:bf, GOC:ch]
is_a: GO:0044384 ! host outer membrane

[Term]
id: GO:0039662
name: host cell outer membrane
namespace: cellular_component
def: "A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell." [GOC:bf, GOC:ch]
synonym: "host cell envelope outer membrane" EXACT [GOC:bf, GOC:ch]
synonym: "outer membrane of host cell" EXACT [GOC:bf, GOC:ch]
is_a: GO:0044384 ! host outer membrane
relationship: part_of GO:0044230 ! host cell envelope

[Term]
id: GO:0039663
name: membrane fusion involved in viral entry into host cell
namespace: biological_process
def: "Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1168]
synonym: "fusion of virus membrane with host membrane" RELATED [UniProtKB-KW:KW-1168]
synonym: "fusion of virus membrane with host membrane during viral entry" RELATED [UniProtKB-KW:KW-1168]
synonym: "viral entry into host cell via membrane fusion" RELATED [GOC:bf, GOC:jl]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0039664
name: lysis of host organelle involved in viral entry into host cell
namespace: biological_process
def: "The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1174, VZ:984]
synonym: "viral entry into host cell via endosome membrane lysis" NARROW [VZ:984]
synonym: "viral entry into host cell via lysis of host organelle membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral membrane-lytic protein" RELATED [UniProtKB-KW:KW-1174]
synonym: "viral penetration via lysis of host organellar membrane" EXACT [UniProtKB-KW:KW-984]
xref: VZ:984 "Viral penetration via lysis of host organellar membrane"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0039665
name: permeabilization of host organelle membrane involved in viral entry into host cell
namespace: biological_process
def: "Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1173, VZ:985]
synonym: "viral entry into host cell via permeabilization of host organelle membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral membrane-penetration protein" RELATED [UniProtKB-KW:KW-1173]
synonym: "viral penetration via host endosomal membrane disruption by virus" EXACT [UniProtKB-KW:KW-1173]
synonym: "viral penetration via perforation of host organellar membrane by virus" EXACT [UniProtKB-KW:KW-1173]
synonym: "viral penetration via permeabilization of host organellar membrane" EXACT [UniProtKB-KW:KW-1173, VZ:985]
xref: VZ:985 "Viral penetration via permeabilization of host organellar membrane"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0140267 ! symbiont entry into host cell via permeabilization of host membrane

[Term]
id: GO:0039666
name: virion attachment to host cell pilus
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side." [UniProtKB-KW:KW-1175, VZ:981]
synonym: "pilus-adsorption protein" EXACT [PMID:16298408]
synonym: "pilus-mediated viral adsorption onto host cell" RELATED [UniProtKB-KW:KW-1175, VZ:981]
synonym: "pilus-mediated viral attachment to host cell" RELATED [GOC:bf, GOC:jl]
synonym: "viral attachment to host cell pilus" RELATED [GOC:bf, GOC:jl]
xref: VZ:981 "Viral attachment to host cell pilus"
is_a: GO:0019062 ! virion attachment to host cell
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0039667
name: obsolete viral entry into host cell via pilus retraction
namespace: biological_process
def: "OBSOLETE. The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus." [GOC:bf, GOC:jl, VZ:981]
comment: This term was obsoleted because it represents the same process as virion attachment to host cell pilus ; GO:0039666.
xref: VZ:981
is_obsolete: true
replaced_by: GO:0039666

[Term]
id: GO:0039668
name: obsolete viral entry into host cell via pilus basal pore
namespace: biological_process
def: "OBSOLETE. The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way." [GOC:bf, GOC:jl]
comment: This term was obsoleted because it represents the same process as virion attachment to host cell pilus ; GO:0039666.
synonym: "filamentous viral entry into host cell via pilus retraction" NARROW [GOC:bf, GOC:jl, VZ:981]
is_obsolete: true
replaced_by: GO:0039666

[Term]
id: GO:0039669
name: obsolete viral entry into host cell via pilus retraction and membrane fusion
namespace: biological_process
def: "OBSOLETE. The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane." [GOC:bf, GOC:jl, PMID:20427561, VZ:981]
comment: This term was obsoleted because it represents the same process as virion attachment to host cell pilus ; GO:0039666.
is_obsolete: true
replaced_by: GO:0039666

[Term]
id: GO:0039670
name: viral capsid, turret
namespace: cellular_component
def: "A turret-like appendage formed at the vertices of an icosahedral capsid." [GOC:jh2, PMID:20592081]
is_a: GO:0098021 ! viral capsid, decoration
relationship: part_of GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0039671
name: symbiont-mediated perturbation of host natural killer cell mediated immune response
namespace: biological_process
def: "A process in which a symbiont alters or subverts the natural killer cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]
synonym: "evasion by virus of host natural killer cell activity" NARROW []
synonym: "evasion by virus of host natural killer cell response" EXACT []
synonym: "evasion by virus of host NK cell killing" EXACT [GOC:bf]
synonym: "modulation of host NK-cell activity by virus" RELATED [UniProtKB-KW:KW-1131]
synonym: "protection by virus against host NK cell cytotoxicity" EXACT [PMID:12782710]
synonym: "suppression by virus of host natural killer cell function" NARROW [PMID:15640804]
synonym: "viral immunoevasion of host NK cell" NARROW [GOC:bf]
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response

[Term]
id: GO:0039672
name: symbiont-mediated suppression of host natural killer cell activation
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts natural killer cell activation in the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:10799855]
synonym: "suppression by virus of host natural killer cell activation" NARROW []
synonym: "suppression by virus of host NK-cell activation" EXACT []
is_a: GO:0039671 ! symbiont-mediated perturbation of host natural killer cell mediated immune response

[Term]
id: GO:0039673
name: symbiont-mediated suppression of host dendritic cell mediated immune response
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the dendritic cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]
synonym: "evasion by virus of host dendritic cell activity" RELATED []
synonym: "evasion by virus of host dendritic cell response" EXACT []
synonym: "impairing dendritic cell function by virus" EXACT [UniProtKB-KW:KW-1118]
synonym: "modulation of host dendritic cell activity by virus" BROAD [UniProtKB-KW:KW-1118]
xref: VZ:869
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response

[Term]
id: GO:0039674
name: exit of virus from host cell nucleus
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus." [VZ:2177]
xref: VZ:2177 "Nuclear exit of viral genome"
is_a: GO:0016032 ! viral process
is_a: GO:0035891 ! exit from host cell

[Term]
id: GO:0039675
name: exit of virus from host cell nucleus through nuclear pore
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore." [PMID:12921991, VZ:1953]
synonym: "exit of virus from host cell nucleus through nuclear pore complex" EXACT []
synonym: "nuclear pore exit of virus" EXACT [VZ:1953]
synonym: "viral enome export through nuclear pore" EXACT [VZ:1953]
xref: VZ:1953 "Genome export through nuclear pore"
is_a: GO:0039674 ! exit of virus from host cell nucleus

[Term]
id: GO:0039677
name: exit of virus from host cell nucleus via nuclear envelope disassembly
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus." [VZ:2176]
synonym: "exit of virus from host cell nucleus via nuclear envelope breakdown" EXACT [VZ:2176]
xref: VZ:2176 "Nuclear envelope breakdown"
is_a: GO:0039674 ! exit of virus from host cell nucleus

[Term]
id: GO:0039678
name: symbiont genome ejection through host cell envelope
namespace: biological_process
def: "Entry of a symbiont's genome into the host cell through the host cell envelope. Occurs in non-enveloped prokaryotic viruses. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm." [GOC:ch, PMID:23385786, PMID:31663016, VZ:986]
synonym: "phage genome ejection" NARROW [PMID:23385786]
synonym: "viral genome ejection through host cell envelope" RELATED []
synonym: "viral genome injection through bacterial membranes" NARROW [VZ:986]
xref: VZ:986 "Viral genome ejection through host cell envelope"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0039679
name: viral occlusion body
namespace: cellular_component
def: "A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host." [UniProtKB-KW:KW-0842, VZ:1949]
xref: VZ:1949 "Occlusion bodies"
is_a: GO:0140220 ! pathogen-containing vacuole

[Term]
id: GO:0039680
name: actin-dependent intracellular transport of virus towards nucleus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments." [UniProtKB-KW:KW-1178, VZ:991]
synonym: "actin-dependent intracellular transport of viral material towards nucleus" EXACT []
synonym: "actin-dependent inwards viral transport" EXACT [VZ:991]
xref: VZ:991 "Actin-dependent inwards viral transport"
is_a: GO:0075520 ! actin-dependent intracellular transport of virus
is_a: GO:0075606 ! transport of viral material towards nucleus

[Term]
id: GO:0039682
name: rolling circle viral DNA replication
namespace: biological_process
def: "A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA." [GOC:bf, GOC:jl, VZ:915, Wikipedia:Rolling_circle_replication]
is_a: GO:0039687 ! viral DNA strand displacement replication

[Term]
id: GO:0039683
name: rolling circle double-stranded viral DNA replication
namespace: biological_process
def: "A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:2676]
synonym: "dsDNA rolling circle replication" EXACT [VZ:2676]
xref: VZ:2676 "dsDNA rolling circle replication"
is_a: GO:0039682 ! rolling circle viral DNA replication

[Term]
id: GO:0039684
name: rolling circle single-stranded viral DNA replication
namespace: biological_process
def: "A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:1941]
synonym: "ssDNA rolling circle replication" EXACT [VZ:1941]
xref: VZ:1941 "ssDNA Rolling circle"
is_a: GO:0039682 ! rolling circle viral DNA replication

[Term]
id: GO:0039685
name: rolling hairpin viral DNA replication
namespace: biological_process
def: "A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA." [GOC:bf, GOC:jl, VZ:2656]
synonym: "ssDNA rolling hairpin viral DNA replication" EXACT [VZ:2656]
xref: VZ:2656 "Rolling hairpin replication"
is_a: GO:0039693 ! viral DNA genome replication

[Term]
id: GO:0039686
name: bidirectional double-stranded viral DNA replication
namespace: biological_process
def: "A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions." [GOC:bf, GOC:jl, VZ:1939]
synonym: "viral bidirectional dsDNA replication" EXACT [VZ:1939]
xref: VZ:1939 "dsDNA bidirectional replication"
is_a: GO:0039693 ! viral DNA genome replication

[Term]
id: GO:0039687
name: viral DNA strand displacement replication
namespace: biological_process
def: "A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA)." [GOC:bf, GOC:jl, VZ:1940]
xref: VZ:1940 "DNA strand displacement replication"
is_a: GO:0039693 ! viral DNA genome replication

[Term]
id: GO:0039688
name: viral double stranded DNA replication via reverse transcription
namespace: biological_process
def: "A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:bf, GOC:jl, VZ:1938]
synonym: "dsDNA replication via RNA intermediate" EXACT [GOC:bf, GOC:jl]
synonym: "RNA-dependent viral DNA replication" RELATED [GOC:bf, GOC:jl]
synonym: "viral RNA-dependent DNA replication" EXACT [GOC:bf, GOC:jl]
xref: VZ:1938 "dsDNA(RT) replication/transcription"
is_a: GO:0039693 ! viral DNA genome replication

[Term]
id: GO:0039689
name: negative stranded viral RNA replication
namespace: biological_process
def: "A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA)." [GOC:bf, GOC:jl, VZ:1096]
synonym: "(-)ss viral RNA replication" EXACT [VZ:1096]
xref: VZ:1096 "Negative stranded RNA virus replication"
is_a: GO:0039694 ! viral RNA genome replication

[Term]
id: GO:0039690
name: positive stranded viral RNA replication
namespace: biological_process
def: "A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA." [GOC:bf, GOC:jl, VZ:1116]
synonym: "ss(+) viral RNA replication" RELATED [VZ:1116]
xref: VZ:1116 "Positive stranded RNA virus replication"
is_a: GO:0039694 ! viral RNA genome replication

[Term]
id: GO:0039691
name: double stranded viral RNA replication
namespace: biological_process
def: "A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA." [GOC:bf, GOC:jl, VZ:1936]
xref: VZ:1936 "Double-stranded RNA virus replication"
is_a: GO:0039694 ! viral RNA genome replication

[Term]
id: GO:0039692
name: single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
alt_id: GO:0045090
def: "A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II." [GOC:bf, GOC:jl, ISBN:0198506732, VZ:1937]
synonym: "retroviral genome replication" EXACT []
synonym: "viral ssRNA replication via dsDNA intermediate" RELATED [GOC:bf]
xref: VZ:1937 "ssRNA(RT) replication/transcription"
is_a: GO:0039694 ! viral RNA genome replication

[Term]
id: GO:0039693
name: viral DNA genome replication
namespace: biological_process
alt_id: GO:0039681
def: "The replication of a viral DNA genome." [GOC:bf, GOC:jl, VZ:915]
subset: goslim_virus
synonym: "DNA-dependent viral DNA replication" EXACT [GOC:bf, GOC:jl]
synonym: "viral DNA replication" EXACT [GOC:bf, GOC:jl]
synonym: "viral DNA-dependent DNA replication" EXACT []
is_a: GO:0019079 ! viral genome replication
is_a: GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:0039694
name: viral RNA genome replication
namespace: biological_process
def: "The replication of a viral RNA genome." [GOC:bf, GOC:jl]
is_a: GO:0019079 ! viral genome replication
is_a: GO:0032774 ! RNA biosynthetic process

[Term]
id: GO:0039695
name: DNA-templated viral transcription
namespace: biological_process
def: "A transcription process that uses a viral DNA as a template." [GOC:bf, GOC:jl]
xref: VZ:1942 "dsDNA templated transcription"
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0039696
name: RNA-templated viral transcription
namespace: biological_process
def: "A transcription process that uses viral RNA as a template." [GOC:bf, GOC:jl]
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0039697
name: negative stranded viral RNA transcription
namespace: biological_process
def: "A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template." [VZ:1096]
xref: VZ:1096 "Negative stranded RNA virus replication"
is_a: GO:0039696 ! RNA-templated viral transcription

[Term]
id: GO:0039698
name: polyadenylation of viral mRNA by polymerase stuttering
namespace: biological_process
def: "Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail." [VZ:1916]
synonym: "polyA stuttering" EXACT [VZ:1916]
xref: VZ:1916 "Negative-stranded RNA virus Polymerase stuttering"
is_a: GO:0016032 ! viral process

[Term]
id: GO:0039699
name: symbiont-mediated evasion of mRNA degradation by host via mRNA cap methylation
namespace: biological_process
def: "An innate immune response evasion mechanism in which a symbiont methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs. This mechanism of immune evasion is used by viruses." [PMID:35215972]
synonym: "evasion of mRNA degradation by host via mRNA cap methylation" EXACT []
synonym: "IFIT mRNA restriction evasion by virus" EXACT [PMID:35215972]
synonym: "viral mRNA cap methylation" RELATED []
is_a: GO:0141177 ! symbiont-mediated evasion of recognition by host innate immune effector

[Term]
id: GO:0039700
name: fusion of viral membrane with host outer nuclear membrane
namespace: biological_process
def: "Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit." [PMID:23057731, UniProtKB-KW:KW-1181]
synonym: "fusion of viral membrane with host outer nuclear membrane involved in nuclear egress" EXACT [GOC:bf]
synonym: "viral primary envelope fusion with host outer nuclear membrane" EXACT [UniProtKB-KW:KW-1181]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress

[Term]
id: GO:0039701
name: microtubule-dependent intracellular transport of viral material towards cell periphery
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane." [UniProtKB-KW:KW-1189, VZ:1816]
xref: VZ:1816 "Microtubular outwards viral transport"
is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material

[Term]
id: GO:0039702
name: viral budding via host ESCRT complex
namespace: biological_process
def: "Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process." [UniProtKB-KW:KW-1187, VZ:1536]
synonym: "host-assisted viral budding" BROAD [VZ:1536]
synonym: "viral budding through the ESCRT machinery" RELATED [VZ:1536]
xref: VZ:1536 "Viral budding via the host ESCRT complexes"
is_a: GO:0046755 ! viral budding

[Term]
id: GO:0039703
name: RNA replication
namespace: biological_process
def: "The cellular metabolic process in which a cell duplicates one or more molecules of RNA." [GOC:bf, GOC:jl]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0039704
name: viral translational shunt
namespace: biological_process
def: "A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site." [PMID:15827182, PMID:18195037, VZ:608]
comment: This term is intended to annotate gene products involved in the process of viral translational shunt, not viral proteins produced by this translation process.
synonym: "ribosomal shunt initiation pathway" EXACT [PMID:18195037]
xref: VZ:608 "Ribosomal shunt"
is_a: GO:0019081 ! viral translation

[Term]
id: GO:0039705
name: viral translational readthrough
namespace: biological_process
def: "The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:bf, GOC:ch, GOC:jl, PMID:10839817, VZ:859]
comment: This term is intended to annotate gene products involved in the process of viral translational readthrough, not viral proteins produced by this translation process.
synonym: "viral RNA suppression of termination" RELATED [VZ:859]
synonym: "viral stop codon readthrough" EXACT [VZ:859]
xref: VZ:859 "RNA suppression of termination"
is_a: GO:0006451 ! translational readthrough
relationship: part_of GO:0019081 ! viral translation

[Term]
id: GO:0039706
name: co-receptor binding
namespace: molecular_function
def: "Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell." [GOC:bf, GOC:jl]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0039707
name: obsolete virus-mediated pore formation in host cell membrane
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism." [GOC:bf, GOC:jl, PMID:12972148]
comment: This term represents a taxon-specific version of the same process, symbiont entry into host cell via pore formation in plasma membrane ; GO:0044694.
synonym: "pore formation by virus in membrane of host cell" EXACT []
synonym: "pore formation in membrane of host cell by virus" EXACT [GOC:bf]
synonym: "viroporin" RELATED [PMID:12972148]
is_obsolete: true

[Term]
id: GO:0039708
name: nuclear capsid assembly
namespace: biological_process
def: "The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly." [VZ:1516]
xref: VZ:1516 "Nuclear capsid assembly"
is_a: GO:0019069 ! viral capsid assembly

[Term]
id: GO:0039709
name: cytoplasmic capsid assembly
namespace: biological_process
def: "The assembly of a virus capsid that occurs in the cytoplasm." [VZ:1950]
xref: VZ:1950 "Cytoplasmic capsid assembly/packaging"
is_a: GO:0019069 ! viral capsid assembly

[Term]
id: GO:0039710
name: cytoplasmic icosahedral capsid assembly
namespace: biological_process
def: "The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome." [VZ:1950]
is_a: GO:0039709 ! cytoplasmic capsid assembly

[Term]
id: GO:0039711
name: cytoplasmic helical capsid assembly
namespace: biological_process
def: "The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome." [VZ:1950]
is_a: GO:0039709 ! cytoplasmic capsid assembly

[Term]
id: GO:0039712
name: obsolete induction by virus of host catalytic activity
namespace: biological_process
def: "OBSOLETE. Any viral process that activates or increases the frequency, rate or extent of host catalytic activity." [GOC:bf, GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "induction by virus of host enzyme activity" EXACT [GOC:bf, GOC:jl]
is_obsolete: true

[Term]
id: GO:0039713
name: viral factory
namespace: cellular_component
def: "An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951]
synonym: "virus factory" EXACT [PMID:22440839]
xref: VZ:1951 "Viral factories"
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0039714
name: cytoplasmic viral factory
namespace: cellular_component
def: "A viral factory located in the cytoplasm of a host cell." [VZ:1951]
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0039713 ! viral factory

[Term]
id: GO:0039715
name: nuclear viral factory
namespace: cellular_component
def: "A viral factory located in the nucleus of a host cell." [VZ:1951]
is_a: GO:0039713 ! viral factory
relationship: part_of GO:0042025 ! host cell nucleus

[Term]
id: GO:0039716
name: viroplasm viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae." [VZ:1951, Wikipedia:Viroplasm]
xref: Wikipedia:Viroplasm
is_a: GO:0039714 ! cytoplasmic viral factory

[Term]
id: GO:0039717
name: spherule viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus." [VZ:1951]
xref: Wikipedia:Viroplasm
is_a: GO:0039714 ! cytoplasmic viral factory

[Term]
id: GO:0039718
name: double membrane vesicle viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae." [PMID:22440839, VZ:1951]
synonym: "DMV viral factory" EXACT [VZ:1951]
is_a: GO:0039714 ! cytoplasmic viral factory

[Term]
id: GO:0039719
name: tube viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories." [VZ:1951]
is_a: GO:0039714 ! cytoplasmic viral factory

[Term]
id: GO:0039720
name: virogenic stroma
namespace: cellular_component
def: "A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled." [PMID:13358757, PMID:1433508, VZ:1951]
synonym: "VS" EXACT [VZ:1951]
is_a: GO:0039715 ! nuclear viral factory

[Term]
id: GO:0039721
name: peristromal region viral factory
namespace: cellular_component
def: "A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses." [PMID:18434402, VZ:1951]
synonym: "PR" RELATED [PMID:18434402, VZ:1951]
is_a: GO:0039715 ! nuclear viral factory

[Term]
id: GO:0039722
name: symbiont-mediated suppression of host toll-like receptor signaling pathway
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a toll-like receptor signaling pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15944308, PMID:17299722, PMID:18327267]
synonym: "inhibition of host TLR pathway by virus" NARROW []
synonym: "suppression by virus of host TLR signaling pathway" NARROW []
synonym: "suppression by virus of host toll-like receptor signaling pathway" NARROW []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0039723
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
namespace: biological_process
def: "Any process in which a symbiont stops, prevents, or reduces a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1." [PMID:22171259, PMID:34084167]
comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
synonym: "inhibition of host TBK1 by virus" RELATED []
synonym: "suppression by virus of host TBK1 activity" RELATED []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity" NARROW []
synonym: "symbiont-mediated suppression of host TKB signaling" RELATED []
xref: VZ:4477
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0039724
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PMID:19153231, PMID:22532683, PMID:24173023]
synonym: "inhibition of host IKBKE by virus" RELATED []
synonym: "suppression by virus of host IKBKE activity" RELATED []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity" NARROW []
xref: VZ:4478
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0040001
name: establishment of mitotic spindle localization
namespace: biological_process
alt_id: GO:0018986
alt_id: GO:0030605
alt_id: GO:0030606
alt_id: GO:0030608
alt_id: GO:0030610
def: "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
synonym: "establishment of mitotic spindle localisation" EXACT [GOC:mah]
synonym: "mitotic spindle positioning" EXACT []
synonym: "mitotic spindle positioning and orientation" NARROW []
synonym: "mitotic spindle positioning or orientation" EXACT []
synonym: "spindle positioning during mitosis" RELATED []
synonym: "spindle positioning involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051293 ! establishment of spindle localization
is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis

[Term]
id: GO:0040002
name: collagen and cuticulin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]
synonym: "collagen and cuticulin-based cuticle anabolism" EXACT []
synonym: "collagen and cuticulin-based cuticle biosynthetic process" EXACT []
synonym: "collagen and cuticulin-based cuticle formation" EXACT []
synonym: "collagen and cuticulin-based cuticle synthesis" EXACT []
is_a: GO:0042335 ! cuticle development

[Term]
id: GO:0040003
name: chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
synonym: "chitin-based cuticle anabolism" EXACT []
synonym: "chitin-based cuticle biosynthetic process" EXACT []
synonym: "chitin-based cuticle formation" EXACT []
synonym: "chitin-based cuticle synthesis" EXACT []
is_a: GO:0042335 ! cuticle development

[Term]
id: GO:0040004
name: collagen and cuticulin-based cuticle attachment to epithelium
namespace: biological_process
def: "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu]
synonym: "cuticular attachment to epithelium" BROAD []
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0040005
name: chitin-based cuticle attachment to epithelium
namespace: biological_process
def: "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "cuticular attachment to epithelium" BROAD []
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0040006
name: obsolete protein-based cuticle attachment to epithelium
namespace: biological_process
def: "OBSOLETE. Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "cuticular attachment to epithelium" BROAD []
synonym: "protein-based cuticle attachment to epithelium" EXACT []
is_obsolete: true
consider: GO:0040004
consider: GO:0040005

[Term]
id: GO:0040007
name: growth
namespace: biological_process
alt_id: GO:0048590
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
comment: See also the biological process term 'cell growth ; GO:0016049'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
synonym: "growth pattern" RELATED []
synonym: "non-developmental growth" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0040008
name: regulation of growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0040007 ! growth

[Term]
id: GO:0040009
name: regulation of growth rate
namespace: biological_process
def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
is_a: GO:0040008 ! regulation of growth

[Term]
id: GO:0040010
name: positive regulation of growth rate
namespace: biological_process
def: "Any process that increases the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
synonym: "activation of growth rate" NARROW []
synonym: "stimulation of growth rate" NARROW []
synonym: "up regulation of growth rate" EXACT []
synonym: "up-regulation of growth rate" EXACT []
synonym: "upregulation of growth rate" EXACT []
is_a: GO:0040009 ! regulation of growth rate
is_a: GO:0045927 ! positive regulation of growth

[Term]
id: GO:0040011
name: locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0040012
name: regulation of locomotion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0040011 ! locomotion

[Term]
id: GO:0040013
name: negative regulation of locomotion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "down regulation of locomotion" EXACT []
synonym: "down-regulation of locomotion" EXACT []
synonym: "downregulation of locomotion" EXACT []
synonym: "inhibition of locomotion" NARROW []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040014
name: regulation of multicellular organism growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040015
name: negative regulation of multicellular organism growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040016
name: embryonic cleavage
namespace: biological_process
def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0040017
name: positive regulation of locomotion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "activation of locomotion" NARROW []
synonym: "stimulation of locomotion" NARROW []
synonym: "up regulation of locomotion" EXACT []
synonym: "up-regulation of locomotion" EXACT []
synonym: "upregulation of locomotion" EXACT []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040018
name: positive regulation of multicellular organism growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040019
name: positive regulation of embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "activation of embryonic development" NARROW []
synonym: "stimulation of embryonic development" NARROW []
synonym: "up regulation of embryonic development" EXACT []
synonym: "up-regulation of embryonic development" EXACT []
synonym: "upregulation of embryonic development" EXACT []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0009790 ! embryo development

[Term]
id: GO:0040020
name: regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
synonym: "regulation of meiosis" BROAD [GOC:vw]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:0051783 ! regulation of nuclear division
relationship: regulates GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0040021
name: hermaphrodite germ-line sex determination
namespace: biological_process
alt_id: GO:0042005
def: "The determination of sex and sexual phenotype in the germ line of a hermaphrodite." [GOC:ems]
is_a: GO:0018992 ! germ-line sex determination

[Term]
id: GO:0040022
name: feminization of hermaphroditic germ-line
namespace: biological_process
def: "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems]
is_a: GO:0040021 ! hermaphrodite germ-line sex determination

[Term]
id: GO:0040024
name: dauer larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X]
is_a: GO:0002119 ! nematode larval development

[Term]
id: GO:0040025
name: vulval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0002119 ! nematode larval development

[Term]
id: GO:0040026
name: positive regulation of vulval development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]
synonym: "activation of vulval development" RELATED []
synonym: "stimulation of vulval development" RELATED []
synonym: "up regulation of vulval development" RELATED []
synonym: "up-regulation of vulval development" RELATED []
synonym: "upregulation of vulval development" RELATED []
is_a: GO:0040028 ! regulation of vulval development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0040025 ! vulval development

[Term]
id: GO:0040027
name: negative regulation of vulval development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]
synonym: "down regulation of vulval development" EXACT []
synonym: "down-regulation of vulval development" EXACT []
synonym: "downregulation of vulval development" EXACT []
synonym: "inhibition of vulval development" NARROW []
is_a: GO:0040028 ! regulation of vulval development
is_a: GO:0061064 ! negative regulation of nematode larval development
relationship: negatively_regulates GO:0040025 ! vulval development

[Term]
id: GO:0040028
name: regulation of vulval development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0040025 ! vulval development

[Term]
id: GO:0040029
name: epigenetic regulation of gene expression
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]
subset: goslim_plant
synonym: "regulation of gene expression, epigenetic" EXACT []
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0040030
name: obsolete regulation of molecular function, epigenetic
namespace: biological_process
def: "OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551]
comment: This term was obsoleted because it is not an active process.
synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0040031
name: snRNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl]
is_a: GO:0009451 ! RNA modification
is_a: GO:0016180 ! snRNA processing

[Term]
id: GO:0040032
name: post-embryonic body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the post-embryonic soma are generated and organized." [GOC:ems, ISBN:0140512888]
comment: Note that this term was 'body morphogenesis (sensu Nematoda)'.
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0010171 ! body morphogenesis

[Term]
id: GO:0040033
name: sRNA-mediated post-transcriptional gene silencing
namespace: biological_process
def: "A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria." [PMID:12460531, PMID:2468565, PMID:33963446]
comment: It is postulated that there 3 mechanisms of sRNA-mediated gene silencing: (i) translation inhibition, (ii) RNA destabilization, and (iii) transcription termination loop formation (as this is common when looking at riboswitches). sRNA mediated gene silencing is sometimes referred to as 'regulation of riboswitch'.
subset: goslim_prokaryote
synonym: "downregulation of mRNA translation, ncRNA-mediated" BROAD []
synonym: "inhibition of mRNA translation, ncRNA-mediated" BROAD []
synonym: "RNA-mediated gene silencing by inhibition of translation" BROAD []
synonym: "small RNA-mediated gene silencing" EXACT []
synonym: "sRNA-mediated gene silencing" BROAD []
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0040034
name: regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]
synonym: "developmental timing" RELATED []
synonym: "heterochronic regulation of development" EXACT []
synonym: "temporal regulation of development" EXACT []
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0040035
name: obsolete hermaphrodite genitalia development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888]
comment: The reason for obsoletion is that this term maybe redundant with female genitalia development.
is_obsolete: true
consider: GO:0030540

[Term]
id: GO:0040036
name: regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "regulation of FGF receptor signaling pathway" EXACT []
synonym: "regulation of FGF receptor signalling pathway" EXACT []
synonym: "regulation of FGFR signaling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0040037
name: negative regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of FGF receptor signaling pathway" EXACT []
synonym: "negative regulation of FGF receptor signalling pathway" EXACT []
synonym: "negative regulation of FGFR signaling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0040038
name: polar body extrusion after meiotic divisions
namespace: biological_process
def: "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732]
is_a: GO:0033206 ! meiotic cytokinesis
relationship: part_of GO:0007143 ! female meiotic nuclear division

[Term]
id: GO:0040039
name: inductive cell migration
namespace: biological_process
def: "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0040040
name: thermosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of temperature." [GOC:ems]
synonym: "behavioral response to temperature stimulus" EXACT []
synonym: "behavioural response to temperature stimulus" EXACT []
synonym: "thermosensory behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0042000
name: translocation of peptides or proteins into host
namespace: biological_process
alt_id: GO:0051808
def: "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, PMID:15953025, PMID:18406478]
synonym: "translocation of peptides or proteins into other organism during symbiotic interaction" BROAD [GOC:tb]
synonym: "translocation of peptides or proteins into other organism involved in symbiotic interaction" BROAD []
synonym: "transport of peptides or proteins into host" EXACT []
synonym: "transport of peptides or proteins into other organism during symbiotic interaction" BROAD []
is_a: GO:0044417 ! translocation of molecules into host

[Term]
id: GO:0042001
name: hermaphrodite somatic sex determination
namespace: biological_process
alt_id: GO:0042002
def: "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0018993 ! somatic sex determination

[Term]
id: GO:0042003
name: masculinization of hermaphrodite soma
namespace: biological_process
def: "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0042001 ! hermaphrodite somatic sex determination

[Term]
id: GO:0042004
name: feminization of hermaphrodite soma
namespace: biological_process
def: "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0042001 ! hermaphrodite somatic sex determination

[Term]
id: GO:0042006
name: masculinization of hermaphroditic germ-line
namespace: biological_process
def: "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0040021 ! hermaphrodite germ-line sex determination

[Term]
id: GO:0042007
name: interleukin-18 binding
namespace: molecular_function
def: "Binding to interleukin-18." [GOC:jl]
synonym: "IL-18 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042008
name: interleukin-18 receptor activity
namespace: molecular_function
def: "Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-18 receptor activity" EXACT [GOC:mah]
synonym: "IL-18R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0042009
name: interleukin-15 binding
namespace: molecular_function
def: "Binding to interleukin-15." [GOC:jl]
synonym: "IL-15 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042010
name: interleukin-15 receptor activity
namespace: molecular_function
def: "Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-15 receptor activity" EXACT [GOC:mah]
synonym: "IL-15R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0042011
name: interleukin-16 binding
namespace: molecular_function
def: "Binding to interleukin-16." [GOC:jl]
synonym: "IL-16 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042012
name: interleukin-16 receptor activity
namespace: molecular_function
def: "Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-16 receptor activity" EXACT [GOC:mah]
synonym: "IL-16R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0042013
name: interleukin-19 binding
namespace: molecular_function
def: "Binding to interleukin-19." [GOC:jl]
synonym: "IL-19 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042014
name: interleukin-19 receptor activity
namespace: molecular_function
def: "Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-19 receptor activity" EXACT [GOC:mah]
synonym: "IL-19R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0042015
name: interleukin-20 binding
namespace: molecular_function
def: "Binding to interleukin-20." [GOC:jl]
synonym: "IL-20 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042016
name: interleukin-20 receptor activity
namespace: molecular_function
def: "Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-20 receptor activity" EXACT [GOC:mah]
synonym: "IL-20R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0042017
name: interleukin-22 binding
namespace: molecular_function
def: "Binding to interleukin-22." [GOC:jl]
synonym: "IL-22 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042018
name: interleukin-22 receptor activity
namespace: molecular_function
def: "Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-22 receptor activity" EXACT [GOC:mah]
synonym: "IL-22R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0042019
name: interleukin-23 binding
namespace: molecular_function
def: "Binding to interleukin-23." [GOC:jl]
synonym: "IL-23 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042020
name: interleukin-23 receptor activity
namespace: molecular_function
def: "Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-23 receptor activity" EXACT [GOC:mah]
synonym: "IL-23R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0042021
name: granulocyte macrophage colony-stimulating factor complex binding
namespace: molecular_function
def: "Binding to a granulocyte macrophage colony-stimulating factor complex." [GOC:ai]
synonym: "GM-CSF complex binding" EXACT []
synonym: "GMC-SF complex binding" EXACT []
synonym: "granulocyte macrophage colony stimulating factor complex binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042022
name: interleukin-12 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits." [GOC:ebc, GOC:mah, PMID:10971505]
synonym: "IL-12 receptor complex" EXACT [GOC:add]
synonym: "IL12RB1-IL12RB2 complex" NARROW [CORUM:2026]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0042023
name: DNA endoreduplication
namespace: biological_process
def: "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
comment: Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states.
synonym: "DNA endoreplication" EXACT []
synonym: "DNA re-duplication" EXACT []
is_a: GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:0042025
name: host cell nucleus
namespace: cellular_component
alt_id: GO:0033649
def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: goslim_virus
is_a: GO:0033648 ! host intracellular membrane-bounded organelle

[Term]
id: GO:0042026
name: protein refolding
namespace: biological_process
def: "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]
synonym: "heat shock protein activity" RELATED []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0042027
name: obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8]
comment: This term was made obsolete because it is contains gene product specific characteristics.
synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" EXACT []
is_obsolete: true
consider: GO:0003755

[Term]
id: GO:0042029
name: obsolete fibrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [PMID:7725320]
comment: This term was made obsolete because it represents a gene product.
synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW []
synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW []
synonym: "fibrinolytic proteinase activity" RELATED []
synonym: "fibrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0042030
name: ATPase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces an ATP hydrolysis activity." [GOC:jl]
synonym: "adenosinetriphosphatase inhibitor" EXACT []
is_a: GO:0060590 ! ATPase regulator activity
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0042031
name: obsolete angiotensin-converting enzyme inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl]
comment: This term was made obsolete because it represents a regulator of a non-existent molecular function term.
synonym: "ACE inhibitor" EXACT []
synonym: "angiotensin-converting enzyme inhibitor activity" EXACT []
synonym: "peptidyl dipeptidase A inhibitor" EXACT []
is_obsolete: true
replaced_by: GO:0060422

[Term]
id: GO:0042034
name: obsolete peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine
namespace: biological_process
def: "OBSOLETE. The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester." [RESID:AA0318]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-lysine esterification" EXACT []
is_obsolete: true

[Term]
id: GO:0042037
name: obsolete peptidyl-histidine methylation, to form pros-methylhistidine
namespace: biological_process
alt_id: GO:0042260
def: "OBSOLETE. The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-histidine pros-methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0042038
name: peptidyl-histidine methylation, to form tele-methylhistidine
namespace: biological_process
alt_id: GO:0042261
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317]
subset: gocheck_obsoletion_candidate
synonym: "peptidyl-histidine tele-methylation" EXACT []
xref: RESID:AA0317
is_a: GO:0018021 ! peptidyl-histidine methylation

[Term]
id: GO:0042039
name: obsolete vanadium incorporation into metallo-sulfur cluster
namespace: biological_process
def: "OBSOLETE. The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n)." [PMID:11053414]
comment: This term was obsoleted because it represents a molecular function.
synonym: "vanadium incorporation into metallo-sulphur cluster" EXACT []
is_obsolete: true

[Term]
id: GO:0042040
name: metal incorporation into metallo-molybdopterin complex
namespace: biological_process
def: "The incorporation of a metal into a metallo-molybdopterin complex." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0042042
name: tungsten incorporation into tungsten-molybdopterin complex
namespace: biological_process
def: "The incorporation of tungsten into a tungsten-molybdopterin complex." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex

[Term]
id: GO:0042043
name: neurexin family protein binding
namespace: molecular_function
alt_id: GO:0019963
def: "Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512]
synonym: "neuroligin" RELATED []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0042044
name: fluid transport
namespace: biological_process
def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0042045
name: epithelial fluid transport
namespace: biological_process
def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]
is_a: GO:0042044 ! fluid transport
is_a: GO:0070633 ! transepithelial transport

[Term]
id: GO:0042046
name: W-molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
synonym: "Moco metabolic process" BROAD []
synonym: "Moco metabolism" BROAD []
synonym: "W-molybdopterin cofactor metabolism" EXACT []
is_a: GO:0043545 ! molybdopterin cofactor metabolic process

[Term]
id: GO:0042047
name: W-molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
synonym: "Moco biosynthesis" BROAD []
synonym: "Moco biosynthetic process" BROAD []
synonym: "W-molybdopterin cofactor anabolism" EXACT []
synonym: "W-molybdopterin cofactor biosynthesis" EXACT []
synonym: "W-molybdopterin cofactor formation" EXACT []
synonym: "W-molybdopterin cofactor synthesis" EXACT []
is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process

[Term]
id: GO:0042048
name: olfactory behavior
namespace: biological_process
def: "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
synonym: "behavioral response to scent" EXACT []
synonym: "behavioral response to smell" EXACT []
synonym: "behavioural response to odour" EXACT []
synonym: "behavioural response to scent" EXACT []
synonym: "behavioural response to smell" EXACT []
synonym: "olfactory behaviour" EXACT []
is_a: GO:0007635 ! chemosensory behavior

[Term]
id: GO:0042049
name: intracellular acyl-CoA homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of acyl-CoA within a cell." [GOC:ai, GOC:dph, GOC:tb]
synonym: "cell acyl-CoA homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "cellular acyl-CoA homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0042051
name: compound eye photoreceptor development
namespace: biological_process
def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
synonym: "adult eye photoreceptor development" NARROW []
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0042052
name: rhabdomere development
namespace: biological_process
def: "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
synonym: "rhabdomere organization" EXACT [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0042053
name: regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "regulation of dopamine metabolism" EXACT []
is_a: GO:0042069 ! regulation of catecholamine metabolic process
relationship: regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0042054
name: histone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]
synonym: "histone methylase activity" EXACT [GOC:mah]
synonym: "histone N-methyltransferase activity" EXACT []
xref: Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)"
xref: Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)"
xref: Reactome:R-HSA-9822583 "METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)"
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0042056
name: chemoattractant activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
synonym: "attractant" BROAD []
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0042057
name: obsolete transforming growth factor beta receptor anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "TGF-beta receptor anchoring activity" EXACT []
synonym: "TGFbeta receptor anchoring activity" EXACT []
synonym: "transforming growth factor beta receptor anchor activity" EXACT []
synonym: "transforming growth factor beta receptor anchoring activity" EXACT []
is_obsolete: true
consider: GO:0005160
consider: GO:0008104

[Term]
id: GO:0042058
name: regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "regulation of EGF receptor signaling pathway" EXACT []
synonym: "regulation of EGF receptor signalling pathway" EXACT []
synonym: "regulation of EGFR signaling pathway" EXACT []
is_a: GO:1901184 ! regulation of ERBB signaling pathway
relationship: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0042059
name: negative regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of EGF receptor signaling pathway" EXACT []
synonym: "negative regulation of EGF receptor signalling pathway" EXACT []
synonym: "negative regulation of EGFR signaling pathway" EXACT []
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:1901185 ! negative regulation of ERBB signaling pathway
relationship: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0042060
name: wound healing
namespace: biological_process
def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
subset: goslim_generic
xref: Wikipedia:Wound_healing
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0042062
name: long-term strengthening of neuromuscular junction
namespace: biological_process
def: "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021]
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: part_of GO:0008582 ! regulation of synaptic assembly at neuromuscular junction

[Term]
id: GO:0042063
name: gliogenesis
namespace: biological_process
def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]
synonym: "glial cell generation" EXACT systematic_synonym []
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0042064
name: obsolete cell adhesion receptor regulator activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cell adhesion receptor regulator activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0030155

[Term]
id: GO:0042065
name: glial cell growth
namespace: biological_process
def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0042066
name: perineurial glial growth
namespace: biological_process
def: "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560]
is_a: GO:0042065 ! glial cell growth

[Term]
id: GO:0042067
name: establishment of ommatidial planar polarity
namespace: biological_process
def: "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
synonym: "establishment of ommatidial polarity" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0042068
name: regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
synonym: "regulation of pteridine metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0042069
name: regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators]
synonym: "regulation of catecholamine metabolism" EXACT []
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042070
name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0048127
def: "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "maintenance of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
synonym: "maintenance of oocyte nucleus position during oocyte axis determination" BROAD []
synonym: "oocyte axis determination, maintenance of oocyte nucleus localization" BROAD []
synonym: "oocyte axis determination, maintenance of oocyte nucleus position" BROAD []
synonym: "oocyte axis determination, oocyte nucleus anchoring" BROAD []
synonym: "oocyte nucleus anchoring during oocyte axis determination" BROAD []
is_a: GO:0051658 ! maintenance of nucleus location
is_a: GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0042071
name: leucokinin receptor activity
namespace: molecular_function
def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:2716741]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0042072
name: obsolete cell adhesion receptor inhibitor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cell adhesion receptor inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0007162

[Term]
id: GO:0042073
name: intraciliary transport
namespace: biological_process
alt_id: GO:0035734
def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "IFT" RELATED []
synonym: "intraflagellar transport" EXACT []
synonym: "intraflagellar transport involved in cilium organization" EXACT []
synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT []
xref: Wikipedia:Intraflagellar_transport
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0031503 ! protein-containing complex localization
relationship: part_of GO:0044782 ! cilium organization

[Term]
id: GO:0042074
name: cell migration involved in gastrulation
namespace: biological_process
def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, PMID:16099638]
is_a: GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0042075
name: obsolete nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310]
comment: This term was obsoleted because it represents a molecular function.
synonym: "nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0042076
name: protein phosphate-linked glycosylation
namespace: biological_process
def: "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424]
synonym: "phosphoglycosylation" EXACT []
synonym: "protein amino acid phosphate-linked glycosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0042077
name: protein phosphate-linked glycosylation via serine
namespace: biological_process
def: "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid phosphate-linked glycosylation via serine" EXACT [GOC:bf]
is_a: GO:0042076 ! protein phosphate-linked glycosylation

[Term]
id: GO:0042078
name: germ-line stem cell division
namespace: biological_process
alt_id: GO:0048131
def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
synonym: "germ-line stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0042079
name: obsolete GPI/GSI anchor metabolic process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "GPI/GSI anchor metabolic process" EXACT []
is_obsolete: true
consider: GO:0006505
consider: GO:0042081

[Term]
id: GO:0042080
name: obsolete GPI/GSI anchor biosynthetic process
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "GPI/GSI anchor anabolism" EXACT []
synonym: "GPI/GSI anchor biosynthesis" EXACT []
synonym: "GPI/GSI anchor biosynthetic process" EXACT []
synonym: "GPI/GSI anchor formation" EXACT []
synonym: "GPI/GSI anchor synthesis" EXACT []
is_obsolete: true
consider: GO:0006506

[Term]
id: GO:0042081
name: GSI anchor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators]
synonym: "GPI/GSI anchor metabolic process" BROAD []
synonym: "GPI/GSI anchor metabolism" BROAD []
synonym: "GSI anchor metabolism" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0042082
name: obsolete GSI anchor biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg]
comment: This term was obsoleted because it represents a molecular function.
synonym: "GPI/GSI anchor biosynthesis" BROAD []
synonym: "GPI/GSI anchor biosynthetic process" BROAD []
synonym: "GSI anchor anabolism" EXACT []
synonym: "GSI anchor biosynthesis" EXACT []
synonym: "GSI anchor formation" EXACT []
synonym: "GSI anchor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0042083
name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042084
name: 5-methyltetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042085
name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042086
name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042088
name: T-helper 1 type immune response
namespace: biological_process
def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149]
synonym: "Th1 immune response" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0042092
name: type 2 immune response
namespace: biological_process
def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518]
synonym: "T-helper 2 type immune response" NARROW [GOC:add]
synonym: "Th2 immune response" NARROW [GOC:add]
is_a: GO:0006955 ! immune response

[Term]
id: GO:0042093
name: T-helper cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc]
synonym: "helper T cell differentiation" EXACT [CL:0000912]
synonym: "T-helper cell development" RELATED [GOC:add]
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response

[Term]
id: GO:0042096
name: obsolete alpha-beta T cell receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
synonym: "alpha-beta T cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0042098
name: T cell proliferation
namespace: biological_process
alt_id: GO:0042111
def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl]
synonym: "T lymphocyte proliferation" EXACT []
synonym: "T-cell proliferation" EXACT []
synonym: "T-lymphocyte proliferation" EXACT []
is_a: GO:0042110 ! T cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0042099
name: obsolete gamma-delta T cell receptor activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
synonym: "gamma-delta T cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0042100
name: B cell proliferation
namespace: biological_process
alt_id: GO:0042114
def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl]
synonym: "B lymphocyte proliferation" EXACT []
synonym: "B-cell proliferation" EXACT []
synonym: "B-lymphocyte proliferation" EXACT []
is_a: GO:0042113 ! B cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0042101
name: T cell receptor complex
namespace: cellular_component
def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149]
synonym: "T lymphocyte receptor complex" EXACT []
synonym: "T-cell receptor complex" EXACT []
synonym: "T-lymphocyte receptor complex" EXACT []
synonym: "TCR" RELATED []
synonym: "TCR complex" EXACT [GOC:bf]
xref: Wikipedia:T_cell_receptor
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0042102
name: positive regulation of T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai]
synonym: "activation of T cell proliferation" NARROW []
synonym: "positive regulation of T lymphocyte proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte proliferation" EXACT []
synonym: "stimulation of T cell proliferation" NARROW []
synonym: "up regulation of T cell proliferation" EXACT []
synonym: "up-regulation of T cell proliferation" EXACT []
synonym: "upregulation of T cell proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042103
name: positive regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl]
synonym: "activation of T cell homeostatic proliferation" NARROW []
synonym: "positive regulation of resting T cell proliferation" EXACT []
synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "positive regulation of T-cell homeostatic proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT []
synonym: "stimulation of T cell homeostatic proliferation" NARROW []
synonym: "up regulation of T cell homeostatic proliferation" EXACT []
synonym: "up-regulation of T cell homeostatic proliferation" EXACT []
synonym: "upregulation of T cell homeostatic proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0042104
name: positive regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl]
synonym: "activation of activated T cell proliferation" NARROW []
synonym: "positive regulation of activated T lymphocyte proliferation" EXACT []
synonym: "positive regulation of activated T-cell proliferation" EXACT []
synonym: "positive regulation of activated T-lymphocyte proliferation" EXACT []
synonym: "stimulation of activated T cell proliferation" NARROW []
synonym: "up regulation of activated T cell proliferation" EXACT []
synonym: "up-regulation of activated T cell proliferation" EXACT []
synonym: "upregulation of activated T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046006 ! regulation of activated T cell proliferation
relationship: positively_regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0042105
name: alpha-beta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte receptor complex" EXACT []
synonym: "alpha-beta T-cell receptor complex" EXACT []
synonym: "alpha-beta T-lymphocyte receptor complex" EXACT []
synonym: "alpha-beta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042106
name: gamma-delta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149]
synonym: "gamma-delta T lymphocyte receptor complex" EXACT []
synonym: "gamma-delta T-cell receptor complex" EXACT []
synonym: "gamma-delta T-lymphocyte receptor complex" EXACT []
synonym: "gamma-delta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042110
name: T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149]
synonym: "T lymphocyte activation" EXACT []
synonym: "T-cell activation" EXACT []
synonym: "T-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0042113
name: B cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149]
synonym: "B lymphocyte activation" EXACT []
synonym: "B-cell activation" EXACT []
synonym: "B-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0042116
name: macrophage activation
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]
synonym: "macrophage polarization" EXACT []
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0042117
name: monocyte activation
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0042118
name: endothelial cell activation
namespace: biological_process
def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0042119
name: neutrophil activation
namespace: biological_process
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0036230 ! granulocyte activation

[Term]
id: GO:0042120
name: alginic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]
synonym: "alginate metabolic process" EXACT []
synonym: "alginate metabolism" EXACT []
synonym: "alginic acid metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0042121
name: alginic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]
synonym: "alginate biosynthesis" EXACT []
synonym: "alginate biosynthetic process" EXACT []
synonym: "alginic acid anabolism" EXACT []
synonym: "alginic acid biosynthesis" EXACT []
synonym: "alginic acid formation" EXACT []
synonym: "alginic acid synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0042120 ! alginic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0042122
name: alginic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]
synonym: "alginate catabolic process" EXACT []
synonym: "alginate catabolism" EXACT []
synonym: "alginic acid breakdown" EXACT []
synonym: "alginic acid catabolism" EXACT []
synonym: "alginic acid degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0042120 ! alginic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0042123
name: glucanosyltransferase activity
namespace: molecular_function
def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0042124
name: 1,3-beta-glucanosyltransferase activity
namespace: molecular_function
def: "Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation." [GOC:jl, PMID:10809732]
is_a: GO:0042123 ! glucanosyltransferase activity

[Term]
id: GO:0042125
name: protein galactosylation
namespace: biological_process
def: "The addition of a galactose molecule to a protein amino acid." [GOC:jl, GOC:pr]
synonym: "protein amino acid galactosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0042126
name: nitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]
synonym: "nitrate metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:2001057 ! reactive nitrogen species metabolic process

[Term]
id: GO:0042127
name: regulation of cell population proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
synonym: "regulation of cell proliferation" RELATED []
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0008283 ! cell population proliferation

[Term]
id: GO:0042128
name: nitrate assimilation
namespace: biological_process
def: "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899]
synonym: "assimilatory nitrate reduction" EXACT []
xref: MetaCyc:PWY-381
is_a: GO:0042126 ! nitrate metabolic process
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0042129
name: regulation of T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl]
synonym: "regulation of T lymphocyte proliferation" EXACT []
synonym: "regulation of T-cell proliferation" EXACT []
synonym: "regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042130
name: negative regulation of T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl]
synonym: "down regulation of T cell proliferation" EXACT []
synonym: "down-regulation of T cell proliferation" EXACT []
synonym: "downregulation of T cell proliferation" EXACT []
synonym: "inhibition of T cell proliferation" NARROW []
synonym: "negative regulation of T lymphocyte proliferation" EXACT []
synonym: "negative regulation of T-cell proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042131
name: thiamine phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate." [PMID:197075, RHEA:47948]
synonym: "thiamin monophosphate phosphatase" EXACT []
synonym: "thiamin phosphate phosphatase activity" EXACT []
synonym: "ThMPase" EXACT []
xref: EC:3.1.3.100
xref: RHEA:47948
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0042132
name: fructose 1,6-bisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11]
synonym: "D-fructose 1,6-diphosphatase activity" RELATED [EC:3.1.3.11]
synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.11]
synonym: "D-fructose-1,6-bisphosphate phosphatase activity" RELATED [EC:3.1.3.11]
synonym: "FBPase activity" RELATED [EC:3.1.3.11]
synonym: "fructose 1,6-bisphosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose 1,6-bisphosphate phosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose 1,6-diphosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose 1,6-diphosphate phosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose bisphosphate phosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose diphosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose diphosphate phosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose-1,6-bisphosphatase activity" RELATED [EC:3.1.3.11]
synonym: "fructose-bisphosphatase activity" BROAD [EC:3.1.3.00]
synonym: "hexose bisphosphatase activity" RELATED [EC:3.1.3.11]
synonym: "hexose diphosphatase activity" RELATED [EC:3.1.3.11]
synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11]
xref: EC:3.1.3.11
xref: MetaCyc:F16BDEPHOS-RXN
xref: Reactome:R-HSA-70479 "FBP tetramers hydrolyze F1,6PP to Fru(6)P"
xref: RHEA:11064
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0042133
name: obsolete neurotransmitter metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl]
comment: The reason for obsoletion is that 'neurotransmitter' is unnecessary grouping in the metabolism branch of the ontology, and it creates true path violations.
synonym: "neurotransmitter metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0042134
name: rRNA primary transcript binding
namespace: molecular_function
def: "Binding to an unprocessed ribosomal RNA transcript." [GOC:jl]
synonym: "pre-rRNA binding" EXACT [PMID:3327689]
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0042135
name: obsolete neurotransmitter catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl]
comment: The reason for obsoletion is that 'neurotransmitter' is unnecessary grouping in the metabolism branch of the ontology, and it creates true path violations.
synonym: "neurotransmitter breakdown" EXACT []
synonym: "neurotransmitter catabolism" EXACT []
synonym: "neurotransmitter degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0042136
name: obsolete neurotransmitter biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl]
comment: The reason for obsoletion is that 'neurotransmitter' is unnecessary grouping in the metabolism branch of the ontology, and it creates true path violations.
synonym: "neurotransmitter anabolism" EXACT []
synonym: "neurotransmitter biosynthesis" EXACT []
synonym: "neurotransmitter biosynthesis and storage" BROAD []
synonym: "neurotransmitter biosynthetic process and storage" BROAD []
synonym: "neurotransmitter formation" EXACT []
synonym: "neurotransmitter synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0042137
name: obsolete sequestering of neurotransmitter
namespace: biological_process
def: "OBSOLETE. The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai]
comment: The reason for obsoletion is that this term represent a molecular function, not biological process.
synonym: "neurotransmitter biosynthesis and storage" RELATED []
synonym: "neurotransmitter biosynthetic process and storage" RELATED []
synonym: "neurotransmitter retention" EXACT []
synonym: "neurotransmitter sequestration" EXACT []
synonym: "neurotransmitter storage" EXACT []
synonym: "retention of neurotransmitter" EXACT []
synonym: "sequestration of neurotransmitter" EXACT []
synonym: "storage of neurotransmitter" EXACT []
is_obsolete: true

[Term]
id: GO:0042138
name: meiotic DNA double-strand break formation
namespace: biological_process
def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:0042139
name: early meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324]
is_a: GO:0007146 ! meiotic recombination nodule assembly

[Term]
id: GO:0042140
name: late meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324]
is_a: GO:0007146 ! meiotic recombination nodule assembly

[Term]
id: GO:0042141
name: obsolete mating pheromone exporter
namespace: molecular_function
def: "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl]
comment: This term was made obsolete because it is too gene product specific.
synonym: "mating pheromone exporter" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0042142
name: obsolete heavy metal chelation
namespace: biological_process
def: "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "heavy metal chelation" EXACT []
is_obsolete: true
replaced_by: GO:0046911

[Term]
id: GO:0042144
name: vacuole fusion, non-autophagic
namespace: biological_process
alt_id: GO:0042145
def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl]
synonym: "homotypic vacuole fusion" EXACT []
synonym: "homotypic vacuole fusion (non-autophagic)" EXACT []
synonym: "homotypic vacuole fusion, non-autophagic" EXACT []
synonym: "vacuole fusion (non-autophagic)" EXACT []
is_a: GO:0097576 ! vacuole fusion

[Term]
id: GO:0042147
name: retrograde transport, endosome to Golgi
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
synonym: "retrograde (endosome to Golgi) transport" EXACT []
is_a: GO:0016197 ! endosomal transport
is_a: GO:0016482 ! cytosolic transport

[Term]
id: GO:0042148
name: DNA strand invasion
namespace: biological_process
def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855]
synonym: "D-loop biosynthesis" RELATED []
synonym: "D-loop formation" RELATED []
synonym: "displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop formation" RELATED [GOC:mah, GOC:vw]
synonym: "Rad51-mediated strand invasion" EXACT [GOC:elh]
synonym: "strand invasion" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0042149
name: cellular response to glucose starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0042150
name: plasmid recombination
namespace: biological_process
def: "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg]
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0042151
name: nematocyst
namespace: cellular_component
def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl]
synonym: "cnidocyst" EXACT []
xref: Wikipedia:Cnidocyte
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0042152
name: RNA-mediated DNA recombination
namespace: biological_process
def: "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627]
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0042153
name: obsolete RPTP-like protein binding
namespace: molecular_function
def: "OBSOLETE. Binding to proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT []
synonym: "RPTP-like protein binding" EXACT []
is_obsolete: true
replaced_by: GO:0005515

[Term]
id: GO:0042156
name: obsolete zinc-mediated transcriptional activator activity
namespace: molecular_function
def: "OBSOLETE. Initiates or upregulates transcription in the presence of zinc." [GOC:jl]
comment: This term was obsoleted because it is defined as a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "zinc-mediated transcriptional activator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0042157
name: lipoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
synonym: "lipoprotein metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0042158
name: lipoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
subset: goslim_pombe
synonym: "lipoprotein anabolism" EXACT []
synonym: "lipoprotein biosynthesis" EXACT []
synonym: "lipoprotein formation" EXACT []
synonym: "lipoprotein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042159
name: lipoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
synonym: "lipoprotein breakdown" EXACT []
synonym: "lipoprotein catabolism" EXACT []
synonym: "lipoprotein degradation" EXACT []
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042160
name: lipoprotein modification
namespace: biological_process
def: "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:mah]
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042161
name: lipoprotein oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group." [GOC:mah]
is_a: GO:0042160 ! lipoprotein modification

[Term]
id: GO:0042162
name: telomeric DNA binding
namespace: molecular_function
def: "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]
synonym: "telomere binding" EXACT []
synonym: "telomeric repeat binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0042163
name: interleukin-12 beta subunit binding
namespace: molecular_function
def: "Binding to the beta subunit of interleukin-12." [GOC:mah]
synonym: "CLMFp40 binding" EXACT []
synonym: "IL-12B binding" EXACT []
synonym: "IL-12p40 binding" EXACT []
synonym: "NKSFp40 binding" EXACT []
is_a: GO:0019972 ! interleukin-12 binding

[Term]
id: GO:0042164
name: interleukin-12 alpha subunit binding
namespace: molecular_function
def: "Binding to the alpha subunit of interleukin-12." [GOC:mah]
synonym: "CLMFp35 binding" EXACT []
synonym: "IL-12A binding" EXACT []
synonym: "IL-12p35 binding" EXACT []
synonym: "NKSFp35 binding" EXACT []
is_a: GO:0019972 ! interleukin-12 binding

[Term]
id: GO:0042165
name: obsolete neurotransmitter binding
namespace: molecular_function
def: "OBSOLETE. Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732]
comment: The reason for obsoletion is that 'neurotransmitter' is unnecessary grouping in the metabolism branch of the ontology, and it creates true path violations.
is_obsolete: true

[Term]
id: GO:0042166
name: acetylcholine binding
namespace: molecular_function
def: "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0042167
name: heme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl]
synonym: "haem catabolic process" EXACT []
synonym: "haem catabolism" EXACT []
synonym: "heme breakdown" EXACT []
synonym: "heme catabolism" EXACT []
synonym: "heme degradation" EXACT []
is_a: GO:0006787 ! porphyrin-containing compound catabolic process
is_a: GO:0042168 ! heme metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0042168
name: heme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]
synonym: "haem metabolic process" EXACT []
synonym: "haem metabolism" EXACT []
synonym: "heme metabolism" EXACT []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0042169
name: SH2 domain binding
namespace: molecular_function
def: "Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0042170
name: plastid membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0042171
name: lysophosphatidic acid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]
synonym: "LPAAT activity" EXACT [PMID:16369050]
is_a: GO:0071617 ! lysophospholipid acyltransferase activity

[Term]
id: GO:0042173
name: regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl]
is_a: GO:0043937 ! regulation of sporulation
relationship: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0042174
name: negative regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation." [GOC:go_curators]
synonym: "down regulation of sporulation" EXACT []
synonym: "down-regulation of sporulation" EXACT []
synonym: "downregulation of sporulation" EXACT []
synonym: "inhibition of sporulation" NARROW []
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043939 ! negative regulation of sporulation
relationship: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0042175
name: nuclear outer membrane-endoplasmic reticulum membrane network
namespace: cellular_component
def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
synonym: "NE-ER continuum" RELATED []
synonym: "NE-ER network" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah]
synonym: "nuclear envelope-ER network" RELATED []
synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah]
synonym: "nuclear membrane-ER network" EXACT [GOC:mah]
is_a: GO:0016020 ! membrane
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0042176
name: regulation of protein catabolic process
namespace: biological_process
alt_id: GO:1903362
alt_id: GO:2000598
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]
synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolic process" EXACT []
synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of cyclin breakdown" NARROW [GOC:obol]
synonym: "regulation of cyclin catabolic process" NARROW []
synonym: "regulation of cyclin catabolism" NARROW [GOC:obol]
synonym: "regulation of cyclin degradation" NARROW [GOC:obol]
synonym: "regulation of degradation of cyclin" NARROW [GOC:obol]
synonym: "regulation of protein breakdown" EXACT []
synonym: "regulation of protein catabolism" EXACT []
synonym: "regulation of protein degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0042177
name: negative regulation of protein catabolic process
namespace: biological_process
alt_id: GO:1903363
alt_id: GO:2000599
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]
synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein catabolic process" EXACT []
synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein catabolic process" EXACT []
synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein catabolic process" EXACT []
synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein catabolic process" NARROW []
synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolic process" EXACT []
synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein breakdown" EXACT []
synonym: "negative regulation of protein catabolism" EXACT []
synonym: "negative regulation of protein degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0042178
name: xenobiotic catabolic process
namespace: biological_process
alt_id: GO:0042737
alt_id: GO:0042738
def: "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organism exposed to it, carried out by individual cells. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc]
subset: goslim_prokaryote
synonym: "drug breakdown" RELATED []
synonym: "drug catabolic process" RELATED []
synonym: "drug catabolism" RELATED []
synonym: "drug degradation" RELATED []
synonym: "exogenous drug breakdown" RELATED []
synonym: "exogenous drug catabolic process" RELATED []
synonym: "exogenous drug catabolism" RELATED []
synonym: "exogenous drug degradation" RELATED []
synonym: "xenobiotic breakdown" EXACT []
synonym: "xenobiotic catabolism" EXACT []
synonym: "xenobiotic degradation" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0042179
name: nicotine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
synonym: "nicotine anabolism" EXACT []
synonym: "nicotine biosynthesis" EXACT []
synonym: "nicotine formation" EXACT []
synonym: "nicotine synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0018933 ! nicotine metabolic process

[Term]
id: GO:0042180
name: ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]
subset: goslim_pir
synonym: "ketone metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042181
name: ketone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
synonym: "ketone anabolism" EXACT []
synonym: "ketone biosynthesis" EXACT []
synonym: "ketone formation" EXACT []
synonym: "ketone synthesis" EXACT []
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0042182
name: ketone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
synonym: "ketone breakdown" EXACT []
synonym: "ketone catabolism" EXACT []
synonym: "ketone degradation" EXACT []
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0042183
name: formate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]
synonym: "formate breakdown" EXACT []
synonym: "formate catabolism" EXACT []
synonym: "formate degradation" EXACT []
synonym: "formic acid catabolic process" EXACT []
synonym: "formic acid catabolism" EXACT []
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042184
name: xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators]
synonym: "xylene breakdown" EXACT []
synonym: "xylene catabolism" EXACT []
synonym: "xylene degradation" EXACT []
is_a: GO:0018948 ! xylene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0042185
name: m-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl]
synonym: "m-xylene breakdown" EXACT []
synonym: "m-xylene catabolism" EXACT []
synonym: "m-xylene degradation" EXACT []
synonym: "meta-xylene catabolic process" EXACT []
synonym: "meta-xylene catabolism" EXACT []
xref: MetaCyc:PWY-142
is_a: GO:0018949 ! m-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042186
name: o-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
synonym: "o-xylene breakdown" EXACT []
synonym: "o-xylene catabolism" EXACT []
synonym: "o-xylene degradation" EXACT []
synonym: "ortho-xylene catabolic process" EXACT []
synonym: "ortho-xylene catabolism" EXACT []
is_a: GO:0018950 ! o-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042187
name: p-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl]
synonym: "p-xylene breakdown" EXACT []
synonym: "p-xylene catabolism" EXACT []
synonym: "p-xylene degradation" EXACT []
synonym: "para-xylene catabolic process" EXACT []
synonym: "para-xylene catabolism" EXACT []
is_a: GO:0018951 ! p-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042188
name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl]
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" EXACT []
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" EXACT []
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation" EXACT []
synonym: "DDT catabolic process" EXACT []
synonym: "DDT catabolism" EXACT []
is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0046701 ! insecticide catabolic process

[Term]
id: GO:0042189
name: vanillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]
synonym: "vanillic aldehyde biosynthesis" EXACT []
synonym: "vanillic aldehyde biosynthetic process" EXACT []
synonym: "vanillin anabolism" EXACT []
synonym: "vanillin biosynthesis" EXACT []
synonym: "vanillin formation" EXACT []
synonym: "vanillin synthesis" EXACT []
is_a: GO:0018982 ! vanillin metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0042190
name: vanillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]
synonym: "vanillic aldehyde catabolic process" EXACT []
synonym: "vanillic aldehyde catabolism" EXACT []
synonym: "vanillin breakdown" EXACT []
synonym: "vanillin catabolism" EXACT []
synonym: "vanillin degradation" EXACT []
is_a: GO:0018982 ! vanillin metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0042191
name: methylmercury metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai]
synonym: "methylmercury metabolism" EXACT []
is_a: GO:0018942 ! organometal metabolic process

[Term]
id: GO:0042192
name: methylmercury biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]
synonym: "methylmercury anabolism" EXACT []
synonym: "methylmercury biosynthesis" EXACT []
synonym: "methylmercury formation" EXACT []
synonym: "methylmercury synthesis" EXACT []
is_a: GO:0042191 ! methylmercury metabolic process
is_a: GO:0046414 ! organomercury biosynthetic process

[Term]
id: GO:0042193
name: methylmercury catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]
synonym: "methylmercury breakdown" EXACT []
synonym: "methylmercury catabolism" EXACT []
synonym: "methylmercury degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042191 ! methylmercury metabolic process

[Term]
id: GO:0042194
name: quinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators]
synonym: "quinate anabolism" EXACT []
synonym: "quinate biosynthesis" EXACT []
synonym: "quinate formation" EXACT []
synonym: "quinate synthesis" EXACT []
synonym: "quinic acid biosynthesis" EXACT []
synonym: "quinic acid biosynthetic process" EXACT []
is_a: GO:0019630 ! quinate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0042195
name: aerobic gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl]
synonym: "aerobic gallate breakdown" EXACT []
synonym: "aerobic gallate catabolism" EXACT []
synonym: "aerobic gallate degradation" EXACT []
synonym: "aerobic gallic acid catabolic process" EXACT []
synonym: "aerobic gallic acid catabolism" EXACT []
is_a: GO:0019396 ! gallate catabolic process

[Term]
id: GO:0042196
name: chlorinated hydrocarbon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms." [GOC:ai, GOC:krc]
synonym: "chlorinated hydrocarbon metabolism" EXACT []
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0042197
name: halogenated hydrocarbon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai, GOC:krc]
synonym: "halogenated hydrocarbon metabolism" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0042198
name: nylon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549]
synonym: "nylon metabolism" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0042199
name: cyanuric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [GOC:curators]
synonym: "cyanuric acid metabolism" EXACT []
is_a: GO:0018965 ! s-triazine compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042200
name: cyanuric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [UM-BBD_pathwayID:cya]
synonym: "cyanuric acid breakdown" EXACT []
synonym: "cyanuric acid catabolism" EXACT []
synonym: "cyanuric acid degradation" EXACT []
xref: UM-BBD_pathwayID:cya
is_a: GO:0042199 ! cyanuric acid metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0042201
name: N-cyclopropylmelamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [GOC:curators]
synonym: "cyromazine metabolic process" EXACT []
synonym: "cyromazine metabolism" EXACT []
synonym: "N-cyclopropylmelamine metabolism" EXACT []
is_a: GO:0018965 ! s-triazine compound metabolic process

[Term]
id: GO:0042202
name: N-cyclopropylmelamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [UM-BBD_pathwayID:cpm]
synonym: "cyromazine catabolic process" EXACT []
synonym: "cyromazine catabolism" EXACT []
synonym: "N-cyclopropylmelamine breakdown" EXACT []
synonym: "N-cyclopropylmelamine catabolism" EXACT []
synonym: "N-cyclopropylmelamine degradation" EXACT []
xref: UM-BBD_pathwayID:cpm
is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process

[Term]
id: GO:0042203
name: toluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [UM-BBD_pathwayID:tol]
synonym: "toluene breakdown" EXACT []
synonym: "toluene catabolism" EXACT []
synonym: "toluene degradation" EXACT []
xref: UM-BBD_pathwayID:tol
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0042204
name: s-triazine compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria]
synonym: "s-triazine compound breakdown" EXACT []
synonym: "s-triazine compound catabolism" EXACT []
synonym: "s-triazine compound degradation" EXACT []
xref: UM-BBD_pathwayID:tria
is_a: GO:0018965 ! s-triazine compound metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0042205
name: chlorinated hydrocarbon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms." [GOC:ai, GOC:krc]
synonym: "chlorinated hydrocarbon breakdown" EXACT []
synonym: "chlorinated hydrocarbon catabolism" EXACT []
synonym: "chlorinated hydrocarbon degradation" EXACT []
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042206 ! halogenated hydrocarbon catabolic process

[Term]
id: GO:0042206
name: halogenated hydrocarbon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms." [GOC:ai, GOC:krc]
synonym: "halogenated hydrocarbon breakdown" EXACT []
synonym: "halogenated hydrocarbon catabolism" EXACT []
synonym: "halogenated hydrocarbon degradation" EXACT []
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0042207
name: styrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl]
synonym: "styrene breakdown" EXACT []
synonym: "styrene catabolism" EXACT []
synonym: "styrene degradation" EXACT []
xref: UM-BBD_pathwayID:sty
is_a: GO:0018966 ! styrene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0042208
name: propylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl]
synonym: "propylene breakdown" EXACT []
synonym: "propylene catabolism" EXACT []
synonym: "propylene degradation" EXACT []
xref: UM-BBD_pathwayID:pro
is_a: GO:0018964 ! propylene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042209
name: orcinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl]
synonym: "orcin catabolic process" EXACT []
synonym: "orcin catabolism" EXACT []
synonym: "orcinol breakdown" EXACT []
synonym: "orcinol catabolism" EXACT []
synonym: "orcinol degradation" EXACT []
xref: UM-BBD_pathwayID:orc
is_a: GO:0018940 ! orcinol metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0042210
name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl]
synonym: "catabolic process of octamethylcyclotetrasiloxane to DMSD" EXACT []
synonym: "catabolism of octamethylcyclotetrasiloxane to DMSD" EXACT []
synonym: "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol" EXACT []
synonym: "octamethylcyclotetrasiloxane degradation to dimethylsilanediol" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018947 ! anaerobic organosilicon metabolic process
is_a: GO:0046454 ! dimethylsilanediol metabolic process
is_a: GO:0046517 ! octamethylcyclotetrasiloxane catabolic process

[Term]
id: GO:0042211
name: dimethylsilanediol catabolic process
namespace: biological_process
def: "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl]
synonym: "catabolic process of DMSD" EXACT []
synonym: "catabolism of DMSD" EXACT []
synonym: "degradation of dimethylsilanediol" EXACT []
synonym: "dimethylsilanediol breakdown" EXACT []
synonym: "dimethylsilanediol catabolism" EXACT []
synonym: "dimethylsilanediol degradation" EXACT []
is_a: GO:0018946 ! aerobic organosilicon metabolic process
is_a: GO:0046454 ! dimethylsilanediol metabolic process
is_a: GO:0046455 ! organosilicon catabolic process

[Term]
id: GO:0042212
name: cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:curators]
synonym: "cresol metabolism" EXACT []
synonym: "hydroxytoluene metabolic process" EXACT []
synonym: "hydroxytoluene metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0042213
name: m-cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl]
synonym: "3-hydroxytoluene catabolic process" EXACT []
synonym: "3-hydroxytoluene catabolism" EXACT []
synonym: "m-cresol breakdown" EXACT []
synonym: "m-cresol catabolism" EXACT []
synonym: "m-cresol degradation" EXACT []
synonym: "meta-cresol catabolic process" EXACT []
synonym: "meta-cresol catabolism" EXACT []
xref: MetaCyc:M-CRESOL-DEGRADATION-PWY
xref: UM-BBD_pathwayID:mcr
is_a: GO:0018925 ! m-cresol metabolic process
is_a: GO:0046199 ! cresol catabolic process

[Term]
id: GO:0042214
name: terpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [GOC:curators]
synonym: "terpene metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0042215
name: anaerobic phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [PMID:12697029]
synonym: "anaerobic phenol-containing compound metabolism" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0042216
name: phenanthrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl]
synonym: "phenanthrene breakdown" EXACT []
synonym: "phenanthrene catabolism" EXACT []
synonym: "phenanthrene degradation" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0018955 ! phenanthrene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0042217
name: 1-aminocyclopropane-1-carboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]
synonym: "1-aminocyclopropane-1-carboxylate breakdown" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate catabolism" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate degradation" EXACT []
is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0042218
name: 1-aminocyclopropane-1-carboxylate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]
synonym: "1-aminocyclopropane-1-carboxylate anabolism" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate biosynthesis" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate formation" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate synthesis" EXACT []
is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0042219
name: modified amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]
synonym: "amino acid derivative catabolic process" EXACT []
synonym: "cellular amino acid derivative breakdown" EXACT []
synonym: "cellular amino acid derivative catabolic process" EXACT []
synonym: "cellular amino acid derivative catabolism" EXACT []
synonym: "cellular amino acid derivative degradation" EXACT []
synonym: "cellular modified amino acid breakdown" EXACT [GOC:mah]
synonym: "cellular modified amino acid catabolic process" EXACT [GOC:mah]
synonym: "cellular modified amino acid catabolism" EXACT [GOC:mah]
synonym: "cellular modified amino acid degradation" EXACT [GOC:mah]
synonym: "modified amino acid catabolism" EXACT [GOC:mah]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0042220
name: response to cocaine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:ef, GOC:jl]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0042221
name: response to chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0042242
name: cobyrinic acid a,c-diamide synthase activity
namespace: molecular_function
alt_id: GO:0043775
def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209, RHEA:26289]
synonym: "CobB" NARROW []
synonym: "cobyrinate a c diamide synthase activity" EXACT []
synonym: "cobyrinate a c-diamide synthase activity" EXACT []
synonym: "cobyrinate a,c diamide synthase activity" EXACT []
synonym: "cobyrinate a,c-diamide synthase activity" EXACT []
xref: EC:6.3.5.11
xref: RHEA:26289
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0042243
name: asexual spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species." [GOC:mah]
synonym: "asexual spore wall formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042244 ! spore wall assembly
relationship: part_of GO:0030436 ! asexual sporulation

[Term]
id: GO:0042244
name: spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]
synonym: "spore coat biosynthesis" EXACT []
synonym: "spore coat biosynthetic process" EXACT []
synonym: "spore wall formation" EXACT []
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0070590 ! spore wall biogenesis

[Term]
id: GO:0042245
name: RNA repair
namespace: biological_process
def: "Any process that results in the repair of damaged RNA." [PMID:11000254, PMID:11070075, UniProtKB-KW:KW-0692]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0042246
name: tissue regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed tissues." [GOC:curators]
is_a: GO:0031099 ! regeneration
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0042247
name: establishment of planar polarity of follicular epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium

[Term]
id: GO:0042248
name: maintenance of polarity of follicular epithelium
namespace: biological_process
def: "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf]
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium

[Term]
id: GO:0042249
name: establishment of planar polarity of embryonic epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0042250
name: maintenance of polarity of embryonic epithelium
namespace: biological_process
def: "The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl]
is_a: GO:0016332 ! establishment or maintenance of polarity of embryonic epithelium

[Term]
id: GO:0042251
name: maintenance of polarity of larval imaginal disc epithelium
namespace: biological_process
def: "The maintenance of an established polarized larval imaginal disc epithelium." [GOC:jl]
is_a: GO:0016336 ! establishment or maintenance of polarity of larval imaginal disc epithelium

[Term]
id: GO:0042252
name: establishment of planar polarity of larval imaginal disc epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates." [GOC:jl]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
alt_id: GO:0007046
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "ribosome biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0042255
name: ribosome assembly
namespace: biological_process
alt_id: GO:0042257
def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]
subset: goslim_yeast
synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw]
is_a: GO:0140694 ! membraneless organelle assembly
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042256
name: cytosolic ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428]
synonym: "mature ribosome assembly" EXACT []
is_a: GO:0042255 ! ribosome assembly

[Term]
id: GO:0042258
name: obsolete molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide
namespace: biological_process
def: "OBSOLETE. The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0042259
name: obsolete peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine" EXACT []
synonym: "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine" EXACT []
synonym: "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine" EXACT []
is_obsolete: true

[Term]
id: GO:0042262
name: DNA protection
namespace: biological_process
def: "Any process in which DNA is protected from damage by, for example, oxidative stress." [GOC:jl]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0042263
name: neuropeptide F receptor activity
namespace: molecular_function
def: "Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa." [GOC:bf, GOC:ma, PMID:21440021]
comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related.
synonym: "NPF receptor activity" EXACT [PMID:21440021]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0042264
name: peptidyl-aspartic acid hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD []
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0042265
name: obsolete peptidyl-asparagine hydroxylation
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD []
is_obsolete: true

[Term]
id: GO:0042267
name: natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "killer activity" RELATED []
synonym: "natural killer cell mediated cell death" EXACT []
synonym: "natural killer cell mediated cell killing" EXACT []
synonym: "natural killer cell mediated cytolysis" RELATED []
synonym: "natural killer-cell mediated cytolysis" RELATED []
synonym: "NK cell mediated cell death" EXACT []
synonym: "NK cell mediated cell killing" EXACT []
synonym: "NK cell mediated cytolysis" RELATED []
synonym: "NK cell mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0042268
name: regulation of cytolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, GOC:mtg_apoptosis]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0019835 ! cytolysis

[Term]
id: GO:0042269
name: regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of natural killer cell mediated cell death" EXACT []
synonym: "regulation of natural killer cell mediated cell killing" EXACT []
synonym: "regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "regulation of natural killer-cell mediated cytolysis" RELATED []
synonym: "regulation of NK cell mediated cell death" EXACT []
synonym: "regulation of NK cell mediated cell killing" EXACT []
synonym: "regulation of NK cell mediated cytolysis" RELATED []
synonym: "regulation of NK cell mediated cytotoxicity" RELATED []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
relationship: regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0042270
name: protection from natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "protection from natural killer cell mediated cell death" EXACT []
synonym: "protection from natural killer cell mediated cell killing" EXACT []
synonym: "protection from natural killer cell mediated cytolysis" RELATED []
synonym: "protection from NK cell mediated cell death" EXACT []
synonym: "protection from NK cell mediated cell killing" EXACT []
synonym: "protection from NK cell mediated cytolysis" RELATED []
synonym: "protection from NK cell mediated cytotoxicity" EXACT []
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity

[Term]
id: GO:0042271
name: susceptibility to natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity.
synonym: "susceptibility to natural killer cell mediated cell death" EXACT []
synonym: "susceptibility to natural killer cell mediated cell killing" EXACT []
synonym: "susceptibility to natural killer cell mediated cytolysis" RELATED []
synonym: "susceptibility to NK cell mediated cell death" EXACT []
synonym: "susceptibility to NK cell mediated cell killing" EXACT []
synonym: "susceptibility to NK cell mediated cytolysis" EXACT []
synonym: "susceptibility to NK cell mediated cytotoxicity" EXACT []
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity

[Term]
id: GO:0042272
name: nuclear RNA export factor complex
namespace: cellular_component
def: "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [PMID:11780633]
synonym: "Mex67-Mtr2 complex" EXACT []
synonym: "NXF1-NXT1 complex" EXACT []
synonym: "TAP-p15 complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0042273
name: ribosomal large subunit biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]
subset: goslim_yeast
synonym: "ribosomal large subunit biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042274
name: ribosomal small subunit biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]
subset: goslim_yeast
synonym: "ribosomal small subunit biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042275
name: error-free postreplication DNA repair
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate." [GOC:elh, GOC:jl, PMID:11459630]
comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
synonym: "error-free PRR" EXACT []
synonym: "error-free replication restart" RELATED []
is_a: GO:0006301 ! postreplication repair

[Term]
id: GO:0042276
name: error-prone translesion synthesis
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]
synonym: "error-prone postreplication DNA repair" RELATED [GOC:elh]
synonym: "mutagenic postreplication DNA repair" RELATED [GOC:elh]
synonym: "mutagenic PRR" EXACT []
is_a: GO:0019985 ! translesion synthesis

[Term]
id: GO:0042277
name: peptide binding
namespace: molecular_function
def: "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042278
name: purine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
synonym: "purine metabolic process" BROAD []
synonym: "purine metabolism" BROAD []
synonym: "purine nucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0042279
name: nitrite reductase (cytochrome, ammonia-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2]
synonym: "ammonia:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.7.2.2]
synonym: "cytochrome c nitrite reductase activity" EXACT []
synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2]
synonym: "multiheme nitrite reductase activity" EXACT []
synonym: "nitrite reductase (cytochrome; ammonia-forming)" RELATED [EC:1.7.2.2]
xref: EC:1.7.2.2
xref: MetaCyc:1.7.2.2-RXN
xref: RHEA:13089
xref: Wikipedia:Cytochrome_c_nitrite_reductase
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0042280
name: obsolete cell surface antigen activity, host-interacting
namespace: molecular_function
def: "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb]
comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "cell surface antigen activity, host-interacting" EXACT []
is_obsolete: true
consider: GO:0044403
consider: GO:0046789

[Term]
id: GO:0042281
name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [GOC:al, MetaCyc:RXN-5470]
synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.267
xref: MetaCyc:RXN-5470
xref: RHEA:30635
is_a: GO:0004583 ! dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

[Term]
id: GO:0042283
name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927]
synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.265
xref: MetaCyc:RXN-5471
xref: RHEA:31307
is_a: GO:0004583 ! dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

[Term]
id: GO:0042284
name: sphingolipid delta-4 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O." [PMID:12417141, RHEA:46544]
synonym: "delta-4 sphingolipid desaturase activity" EXACT []
xref: EC:1.14.19.17
xref: Reactome:R-HSA-428259 "DEGS1 dehydrogenates dihydroceramide"
xref: RHEA:46544
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0042285
name: xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0042286
name: glutamate-1-semialdehyde 2,1-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [RHEA:14265]
synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" RELATED [EC:5.4.3.8]
synonym: "glutamate-1-semialdehyde aminotransferase activity" RELATED [EC:5.4.3.8]
xref: EC:5.4.3.8
xref: KEGG_REACTION:R02272
xref: MetaCyc:GSAAMINOTRANS-RXN
xref: RHEA:14265
is_a: GO:0016869 ! intramolecular aminotransferase activity

[Term]
id: GO:0042287
name: MHC protein binding
namespace: molecular_function
def: "Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "major histocompatibility complex binding" EXACT []
synonym: "major histocompatibility complex ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0042288
name: MHC class I protein binding
namespace: molecular_function
def: "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "major histocompatibility complex class I binding" EXACT []
synonym: "major histocompatibility complex class I ligand" NARROW []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0042289
name: MHC class II protein binding
namespace: molecular_function
def: "Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "major histocompatibility complex class II binding" EXACT []
synonym: "major histocompatibility complex class II ligand" NARROW []
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0042290
name: obsolete URM1 hydrolase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "URM1 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0042291
name: obsolete Hub1 hydrolase activity
namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "Hub1 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0042292
name: URM1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0042293
name: Hub1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0042294
name: URM1 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages." [GOC:mah, PMID:12826404]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0042296
name: ISG15 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages." [GOC:mah, PMID:12826404]
synonym: "ISG15 conjugating enzyme activity" NARROW []
xref: Reactome:R-HSA-5653754 "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA"
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0042297
name: vocal learning
namespace: biological_process
def: "A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]
comment: Examples include language learning by human infants and song learning in zebra finches.
xref: Wikipedia:Vocal_learning
is_a: GO:0031223 ! auditory behavior
is_a: GO:0098596 ! imitative learning
is_a: GO:0098598 ! learned vocalization behavior or vocal learning

[Term]
id: GO:0042299
name: lupeol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol." [MetaCyc:RXN-111, PMID:9883589]
synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.41
xref: MetaCyc:RXN-111
xref: RHEA:31383
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042300
name: beta-amyrin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin." [PMID:9746369, RHEA:31007]
synonym: "2,3-oxidosqualene beta-amyrin cyclase" EXACT [EC:5.4.99.39]
synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.39
xref: MetaCyc:RXN-7570
xref: RHEA:31007
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042301
name: phosphate ion binding
namespace: molecular_function
def: "Binding to a phosphate ion." [GOC:jl]
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0042302
name: structural constituent of cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
subset: goslim_drosophila
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0042303
name: molting cycle
namespace: biological_process
def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0042304
name: regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl]
synonym: "regulation of fatty acid anabolism" EXACT []
synonym: "regulation of fatty acid biosynthesis" EXACT []
synonym: "regulation of fatty acid formation" EXACT []
synonym: "regulation of fatty acid synthesis" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042305
name: specification of segmental identity, mandibular segment
namespace: biological_process
def: "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0042306
name: regulation of protein import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]
synonym: "regulation of protein import into cell nucleus" EXACT []
synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of protein-nucleus import" EXACT []
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
is_a: GO:1900180 ! regulation of protein localization to nucleus
relationship: regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042307
name: positive regulation of protein import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "activation of protein import into nucleus" NARROW []
synonym: "positive regulation of protein import into cell nucleus" EXACT []
synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of protein-nucleus import" EXACT []
synonym: "stimulation of protein import into nucleus" NARROW []
synonym: "up regulation of protein import into nucleus" EXACT []
synonym: "up-regulation of protein import into nucleus" EXACT []
synonym: "upregulation of protein import into nucleus" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
relationship: positively_regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042308
name: negative regulation of protein import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "down regulation of protein import into nucleus" EXACT []
synonym: "down-regulation of protein import into nucleus" EXACT []
synonym: "downregulation of protein import into nucleus" EXACT []
synonym: "inhibition of protein import into nucleus" NARROW []
synonym: "negative regulation of protein import into cell nucleus" EXACT []
synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of protein-nucleus import" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
relationship: negatively_regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042309
name: homoiothermy
namespace: biological_process
def: "Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023]
synonym: "antifreeze activity" RELATED []
synonym: "ice nucleation activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0042310
name: vasoconstriction
namespace: biological_process
alt_id: GO:0045908
def: "A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure." [GOC:pr, ISBN:0192800752]
synonym: "negative regulation of blood vessel size" EXACT []
xref: Wikipedia:Vasoconstriction
is_a: GO:0097746 ! blood vessel diameter maintenance

[Term]
id: GO:0042311
name: vasodilation
namespace: biological_process
alt_id: GO:0045909
def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure." [GOC:pr, ISBN:0192800981]
synonym: "positive regulation of blood vessel size" EXACT []
synonym: "vasodilatation" EXACT []
xref: Wikipedia:Vasodilation
is_a: GO:0097746 ! blood vessel diameter maintenance

[Term]
id: GO:0042313
name: protein kinase C deactivation
namespace: biological_process
def: "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf]
synonym: "PKC deactivation" EXACT []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway

[Term]
id: GO:0042314
name: bacteriochlorophyll binding
namespace: molecular_function
def: "Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981]
is_a: GO:0016168 ! chlorophyll binding

[Term]
id: GO:0042315
name: obsolete cytosol nonspecific dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytosol nonspecific dipeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0042316
name: penicillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732]
synonym: "penicillin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0042317
name: penicillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732]
synonym: "penicillin breakdown" EXACT []
synonym: "penicillin catabolism" EXACT []
synonym: "penicillin degradation" EXACT []
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:0042316 ! penicillin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0042318
name: penicillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732]
synonym: "penicillin anabolism" EXACT []
synonym: "penicillin biosynthesis" EXACT []
synonym: "penicillin formation" EXACT []
synonym: "penicillin synthesis" EXACT []
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0042316 ! penicillin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0042320
name: regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998]
synonym: "regulation of REM sleep" EXACT []
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0042321
name: negative regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981]
synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW []
synonym: "negative regulation of sleep" EXACT []
is_a: GO:0042754 ! negative regulation of circadian rhythm
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
is_a: GO:0048521 ! negative regulation of behavior
relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042322
name: negative regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl]
synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "negative regulation of REM sleep" EXACT []
is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep
is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep
relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0042323
name: negative regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl]
synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "negative regulation of non-REM sleep" EXACT []
is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep
is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep
relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0042324
name: orexin receptor binding
namespace: molecular_function
def: "Binding to an orexin receptor." [GOC:ceb, PMID:11988773]
synonym: "hypocretin receptor binding" EXACT []
synonym: "hypocretin receptor ligand" NARROW []
synonym: "orexin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0042325
name: regulation of phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_obsoletion_candidate
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042326
name: negative regulation of phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_obsoletion_candidate
synonym: "down regulation of phosphorylation" EXACT []
synonym: "down-regulation of phosphorylation" EXACT []
synonym: "downregulation of phosphorylation" EXACT []
synonym: "inhibition of phosphorylation" NARROW []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
relationship: negatively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042327
name: positive regulation of phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]
synonym: "activation of phosphorylation" NARROW []
synonym: "stimulation of phosphorylation" NARROW []
synonym: "up regulation of phosphorylation" EXACT []
synonym: "up-regulation of phosphorylation" EXACT []
synonym: "upregulation of phosphorylation" EXACT []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
relationship: positively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042328
name: heparan sulfate N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma]
synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT []
synonym: "heparin N-acetylglucosaminyltransferase activity" RELATED []
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0042329
name: structural constituent of collagen and cuticulin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu]
synonym: "structural constituent of cuticle" BROAD []
is_a: GO:0042302 ! structural constituent of cuticle

[Term]
id: GO:0042330
name: taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023]
synonym: "directed movement in response to stimulus" EXACT []
xref: Wikipedia:Taxis
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0009605 ! response to external stimulus

[Term]
id: GO:0042331
name: phototaxis
namespace: biological_process
alt_id: GO:0046953
def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
synonym: "phototactic behavior" EXACT []
synonym: "phototactic behaviour" EXACT []
synonym: "taxis in response to light" EXACT []
xref: Wikipedia:Phototaxis
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042332
name: gravitaxis
namespace: biological_process
alt_id: GO:0048062
def: "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
synonym: "geotactic behavior" EXACT []
synonym: "geotactic behaviour" EXACT []
synonym: "geotaxis" EXACT []
synonym: "gravitactic behavior" EXACT []
synonym: "gravitactic behaviour" EXACT []
synonym: "taxis in response to gravitational stimulus" EXACT []
synonym: "taxis in response to gravity" EXACT []
is_a: GO:0009629 ! response to gravity
is_a: GO:0042330 ! taxis

[Term]
id: GO:0042333
name: chemotaxis to oxidizable substrate
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423]
synonym: "taxis in response to oxidizable substrate" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042334
name: taxis to electron acceptor
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423]
synonym: "taxis in response to electron acceptor" EXACT []
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042335
name: cuticle development
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825]
subset: goslim_drosophila
synonym: "cuticle anabolism" EXACT []
synonym: "cuticle biosynthesis" EXACT []
synonym: "cuticle biosynthetic process" EXACT []
synonym: "cuticle formation" EXACT []
synonym: "cuticle synthesis" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0042336
name: obsolete cuticle development involved in protein-based cuticle molting cycle
namespace: biological_process
def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species." [GOC:dph, GOC:mtg_sensu, GOC:tb]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle development involved in protein-based cuticle molting cycle" EXACT []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_obsolete: true
consider: GO:0042337
consider: GO:0042338

[Term]
id: GO:0042337
name: cuticle development involved in chitin-based cuticle molting cycle
namespace: biological_process
def: "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:jl, GOC:mtg_sensu, GOC:tb]
synonym: "chitin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb]
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0042338
name: cuticle development involved in collagen and cuticulin-based cuticle molting cycle
namespace: biological_process
def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]
synonym: "collagen and cuticulin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb]
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_a: GO:0040002 ! collagen and cuticulin-based cuticle development
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0042339
name: keratan sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]
synonym: "keratan sulfate metabolism" EXACT []
synonym: "keratan sulphate metabolic process" EXACT []
synonym: "keratan sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process

[Term]
id: GO:0042340
name: keratan sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]
synonym: "keratan sulfate breakdown" EXACT []
synonym: "keratan sulfate catabolism" EXACT []
synonym: "keratan sulfate degradation" EXACT []
synonym: "keratan sulphate catabolic process" EXACT []
synonym: "keratan sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0042339 ! keratan sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0042341
name: cyanogenic glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]
synonym: "cyanogenic glycoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0042342
name: cyanogenic glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]
synonym: "cyanogenic glycoside breakdown" EXACT []
synonym: "cyanogenic glycoside catabolism" EXACT []
synonym: "cyanogenic glycoside degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0042341 ! cyanogenic glycoside metabolic process
is_a: GO:0050899 ! nitrile catabolic process

[Term]
id: GO:0042343
name: indole glucosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [GOC:curators]
synonym: "indole glucosinolate metabolism" EXACT []
is_a: GO:0019760 ! glucosinolate metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0042344
name: indole glucosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [PMID:29122987]
synonym: "indole glucosinolate breakdown" EXACT []
synonym: "indole glucosinolate catabolism" EXACT []
synonym: "indole glucosinolate degradation" EXACT []
is_a: GO:0019762 ! glucosinolate catabolic process
is_a: GO:0042343 ! indole glucosinolate metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process

[Term]
id: GO:0042349
name: guiding stereospecific synthesis activity
namespace: molecular_function
def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma]
synonym: "dirigent protein" NARROW []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0042350
name: GDP-L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl]
synonym: "GDP-L-fucose anabolism" EXACT []
synonym: "GDP-L-fucose biosynthesis" EXACT []
synonym: "GDP-L-fucose formation" EXACT []
synonym: "GDP-L-fucose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046368 ! GDP-L-fucose metabolic process

[Term]
id: GO:0042351
name: 'de novo' GDP-L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [PMID:11030750]
synonym: "'de novo' GDP-L-fucose anabolism" EXACT []
synonym: "'de novo' GDP-L-fucose biosynthesis" EXACT []
synonym: "'de novo' GDP-L-fucose formation" EXACT []
synonym: "'de novo' GDP-L-fucose synthesis" EXACT []
synonym: "GDP-L-fucose biosynthesis, de novo pathway" EXACT []
synonym: "GDP-L-fucose biosynthetic process, de novo pathway" EXACT []
xref: MetaCyc:PWY-66
is_a: GO:0019673 ! GDP-mannose metabolic process
is_a: GO:0042350 ! GDP-L-fucose biosynthetic process

[Term]
id: GO:0042352
name: GDP-L-fucose salvage
namespace: biological_process
def: "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma]
synonym: "GDP-L-fucose biosynthesis, salvage pathway" EXACT []
synonym: "GDP-L-fucose biosynthetic process, salvage pathway" EXACT []
xref: MetaCyc:PWY-6
is_a: GO:0042350 ! GDP-L-fucose biosynthetic process
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0042353
name: fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl]
synonym: "fucose anabolism" EXACT []
synonym: "fucose biosynthesis" EXACT []
synonym: "fucose formation" EXACT []
synonym: "fucose synthesis" EXACT []
is_a: GO:0006004 ! fucose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0042354
name: L-fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732]
synonym: "L-fucose metabolism" EXACT []
is_a: GO:0006004 ! fucose metabolic process

[Term]
id: GO:0042355
name: L-fucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl]
synonym: "L-fucose breakdown" EXACT []
synonym: "L-fucose catabolism" EXACT []
synonym: "L-fucose degradation" EXACT []
is_a: GO:0019317 ! fucose catabolic process
is_a: GO:0042354 ! L-fucose metabolic process

[Term]
id: GO:0042356
name: GDP-4-dehydro-D-rhamnose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [EC:1.1.1.187]
synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" RELATED [EC:1.1.1.187]
synonym: "GDP-4-keto-D-rhamnose reductase activity" RELATED [EC:1.1.1.187]
synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" RELATED [EC:1.1.1.187]
synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" RELATED [EC:1.1.1.187]
xref: EC:1.1.1.187
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042357
name: thiamine diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732]
synonym: "thiamin diphosphate metabolic process" EXACT []
synonym: "thiamin diphosphate metabolism" EXACT []
synonym: "thiamin pyrophosphate metabolic process" EXACT []
synonym: "thiamin pyrophosphate metabolism" EXACT []
synonym: "thiamine diphosphate metabolism" EXACT []
synonym: "thiamine pyrophosphate metabolic process" EXACT []
synonym: "thiamine pyrophosphate metabolism" EXACT []
synonym: "TPP metabolic process" EXACT []
synonym: "TPP metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042723 ! thiamine-containing compound metabolic process

[Term]
id: GO:0042358
name: thiamine diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732]
synonym: "thiamin diphosphate breakdown" EXACT []
synonym: "thiamin diphosphate catabolic process" EXACT []
synonym: "thiamin diphosphate catabolism" EXACT []
synonym: "thiamin diphosphate degradation" EXACT []
synonym: "thiamin pyrophosphate catabolic process" EXACT []
synonym: "thiamin pyrophosphate catabolism" EXACT []
synonym: "thiamine diphosphate catabolism" EXACT []
synonym: "thiamine pyrophosphate catabolic process" EXACT []
synonym: "thiamine pyrophosphate catabolism" EXACT []
synonym: "TPP catabolic process" EXACT []
synonym: "TPP catabolism" EXACT []
is_a: GO:0042357 ! thiamine diphosphate metabolic process
is_a: GO:0042725 ! thiamine-containing compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0042359
name: vitamin D metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309]
synonym: "calciferol metabolic process" NARROW []
synonym: "calciferol metabolism" NARROW []
synonym: "cholecalciferol metabolic process" NARROW []
synonym: "cholecalciferol metabolism" NARROW []
synonym: "ergocalciferol metabolic process" NARROW []
synonym: "ergocalciferol metabolism" NARROW []
synonym: "vitamin D metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042360
name: vitamin E metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732]
synonym: "alpha-tocopherol metabolic process" NARROW []
synonym: "alpha-tocopherol metabolism" NARROW []
synonym: "tocopherol metabolic process" EXACT []
synonym: "tocopherol metabolism" EXACT []
synonym: "vitamin E metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042361
name: menaquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, PMID:37938463]
synonym: "menaquinone breakdown" EXACT []
synonym: "menaquinone catabolism" EXACT []
synonym: "menaquinone degradation" EXACT []
synonym: "menatetrenone catabolic process" EXACT []
synonym: "menatetrenone catabolism" EXACT []
synonym: "multiprenylmenaquinone catabolic process" EXACT []
synonym: "multiprenylmenaquinone catabolism" EXACT []
synonym: "vitamin K2 catabolic process" EXACT []
synonym: "vitamin K2 catabolism" EXACT []
is_a: GO:0009233 ! menaquinone metabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0042362
name: fat-soluble vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]
synonym: "fat-soluble vitamin anabolism" EXACT []
synonym: "fat-soluble vitamin biosynthesis" EXACT []
synonym: "fat-soluble vitamin formation" EXACT []
synonym: "fat-soluble vitamin synthesis" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0009110 ! vitamin biosynthetic process

[Term]
id: GO:0042363
name: fat-soluble vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]
synonym: "fat-soluble vitamin breakdown" EXACT []
synonym: "fat-soluble vitamin catabolism" EXACT []
synonym: "fat-soluble vitamin degradation" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0009111 ! vitamin catabolic process

[Term]
id: GO:0042364
name: water-soluble vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl]
synonym: "water-soluble vitamin anabolism" EXACT []
synonym: "water-soluble vitamin biosynthesis" EXACT []
synonym: "water-soluble vitamin formation" EXACT []
synonym: "water-soluble vitamin synthesis" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009110 ! vitamin biosynthetic process

[Term]
id: GO:0042365
name: water-soluble vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, PMID:24365359]
synonym: "water-soluble vitamin breakdown" EXACT []
synonym: "water-soluble vitamin catabolism" EXACT []
synonym: "water-soluble vitamin degradation" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009111 ! vitamin catabolic process

[Term]
id: GO:0042366
name: cobalamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
synonym: "cobalamin breakdown" EXACT []
synonym: "cobalamin catabolism" EXACT []
synonym: "cobalamin degradation" EXACT []
synonym: "vitamin B12 catabolic process" EXACT []
synonym: "vitamin B12 catabolism" EXACT []
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process

[Term]
id: GO:0042367
name: biotin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732]
synonym: "biotin breakdown" EXACT []
synonym: "biotin catabolism" EXACT []
synonym: "biotin degradation" EXACT []
synonym: "vitamin B7 catabolic process" EXACT []
synonym: "vitamin B7 catabolism" EXACT []
synonym: "vitamin H catabolic process" EXACT []
synonym: "vitamin H catabolism" EXACT []
is_a: GO:0006768 ! biotin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0043605 ! amide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042368
name: vitamin D biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309]
synonym: "calciferol biosynthesis" NARROW []
synonym: "calciferol biosynthetic process" NARROW []
synonym: "cholecalciferol biosynthesis" NARROW []
synonym: "cholecalciferol biosynthetic process" NARROW []
synonym: "ergocalciferol biosynthesis" NARROW []
synonym: "ergocalciferol biosynthetic process" NARROW []
synonym: "vitamin D anabolism" EXACT []
synonym: "vitamin D biosynthesis" EXACT []
synonym: "vitamin D formation" EXACT []
synonym: "vitamin D synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0042369
name: vitamin D catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309]
synonym: "calciferol catabolic process" NARROW []
synonym: "calciferol catabolism" NARROW []
synonym: "cholecalciferol biosynthesis" NARROW []
synonym: "cholecalciferol biosynthetic process" NARROW []
synonym: "ergocalciferol biosynthesis" NARROW []
synonym: "ergocalciferol biosynthetic process" NARROW []
synonym: "vitamin D breakdown" EXACT []
synonym: "vitamin D catabolism" EXACT []
synonym: "vitamin D degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0042370
name: thiamine diphosphate dephosphorylation
namespace: biological_process
def: "The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732]
synonym: "thiamin diphosphate dephosphorylation" EXACT []
synonym: "TPP dephosphorylation" EXACT []
is_a: GO:0042357 ! thiamine diphosphate metabolic process

[Term]
id: GO:0042371
name: vitamin K biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, https://en.wikipedia.org/wiki/Vitamin_K, PMID:24489112]
synonym: "naphthoquinone metabolic process" BROAD []
synonym: "naphthoquinone metabolism" BROAD []
synonym: "vitamin K anabolism" EXACT []
synonym: "vitamin K biosynthesis" EXACT []
synonym: "vitamin K formation" EXACT []
synonym: "vitamin K synthesis" EXACT []
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process
is_a: GO:0042373 ! vitamin K metabolic process

[Term]
id: GO:0042372
name: phylloquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, https://doi.org/10.1016/B978-0-12-385853-5.00001-5, PMID:23821151, PMID:27337968]
synonym: "phylloquinone anabolism" EXACT []
synonym: "phylloquinone biosynthesis" EXACT []
synonym: "phylloquinone formation" EXACT []
synonym: "phylloquinone synthesis" EXACT []
synonym: "phytomenadione biosynthesis" EXACT []
synonym: "phytomenadione biosynthetic process" EXACT []
synonym: "phytonadione biosynthesis" EXACT []
synonym: "phytonadione biosynthetic process" EXACT []
synonym: "phytylmenaquinone biosynthesis" EXACT []
synonym: "phytylmenaquinone biosynthetic process" EXACT []
synonym: "vitamin K1 biosynthesis" EXACT []
synonym: "vitamin K1 biosynthetic process" EXACT []
xref: MetaCyc:PWY-5027
is_a: GO:0042371 ! vitamin K biosynthetic process
is_a: GO:0042374 ! phylloquinone metabolic process

[Term]
id: GO:0042373
name: vitamin K metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, https://en.wikipedia.org/wiki/Vitamin_K, PMID:24489112]
synonym: "naphthoquinone metabolic process" BROAD []
synonym: "naphthoquinone metabolism" BROAD []
synonym: "vitamin K metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0042374
name: phylloquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, https://doi.org/10.1016/B978-0-12-385853-5.00001-5, PMID:27337968]
synonym: "phylloquinone metabolism" EXACT []
synonym: "phytomenadione metabolic process" EXACT []
synonym: "phytomenadione metabolism" EXACT []
synonym: "phytonadione metabolic process" EXACT []
synonym: "phytonadione metabolism" EXACT []
synonym: "phytylmenaquinone metabolic process" EXACT []
synonym: "phytylmenaquinone metabolism" EXACT []
synonym: "vitamin K1 metabolic process" EXACT []
synonym: "vitamin K1 metabolism" EXACT []
is_a: GO:0042373 ! vitamin K metabolic process

[Term]
id: GO:0042376
name: phylloquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, https://doi.org/10.1016/B978-0-12-385853-5.00001-5, PMID:27337968]
synonym: "phylloquinone breakdown" EXACT []
synonym: "phylloquinone catabolism" EXACT []
synonym: "phylloquinone degradation" EXACT []
synonym: "phytomenadione catabolic process" EXACT []
synonym: "phytomenadione catabolism" EXACT []
synonym: "phytonadione catabolic process" EXACT []
synonym: "phytonadione catabolism" EXACT []
synonym: "phytylmenaquinone catabolic process" EXACT []
synonym: "phytylmenaquinone catabolism" EXACT []
synonym: "vitamin K1 catabolic process" EXACT []
synonym: "vitamin K1 catabolism" EXACT []
is_a: GO:0042374 ! phylloquinone metabolic process
is_a: GO:0042377 ! vitamin K catabolic process

[Term]
id: GO:0042377
name: vitamin K catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, https://en.wikipedia.org/wiki/Vitamin_K, PMID:24489112]
synonym: "naphthoquinone catabolic process" EXACT []
synonym: "naphthoquinone catabolism" EXACT []
synonym: "vitamin K breakdown" EXACT []
synonym: "vitamin K catabolism" EXACT []
synonym: "vitamin K degradation" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:0042373 ! vitamin K metabolic process

[Term]
id: GO:0042379
name: chemokine receptor binding
namespace: molecular_function
def: "Binding to a chemokine receptor." [GOC:ai]
synonym: "chemokine receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0042380
name: hydroxymethylbutenyl pyrophosphate reductase activity
namespace: molecular_function
def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js, PMID:11818558]
synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0042381
name: hemolymph coagulation
namespace: biological_process
def: "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
synonym: "hemolymph clotting" EXACT []
is_a: GO:0006959 ! humoral immune response
is_a: GO:0007599 ! hemostasis
is_a: GO:0045087 ! innate immune response
is_a: GO:0050817 ! coagulation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0042382
name: paraspeckles
namespace: cellular_component
def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]
xref: Wikipedia:Paraspeckle
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0042383
name: sarcolemma
namespace: cellular_component
def: "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]
xref: Wikipedia:Sarcolemma
is_a: GO:0005886 ! plasma membrane

[Term]
id: GO:0042385
name: myosin III complex
namespace: cellular_component
def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, PMID:33718386]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0042386
name: hemocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]
synonym: "arthropod blood cell differentiation" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0042387
name: plasmatocyte differentiation
namespace: biological_process
def: "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791]
is_a: GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0042388
name: gibberellic acid mediated signaling pathway, G-alpha-dependent
namespace: biological_process
def: "The series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]
synonym: "gibberellic acid mediated signalling, G-alpha-dependent" EXACT []
is_a: GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0042389
name: omega-3 fatty acid desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0042390
name: gibberellic acid mediated signaling pathway, G-alpha-independent
namespace: biological_process
def: "The series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]
synonym: "gibberellic acid mediated signalling, G-alpha-independent" EXACT []
is_a: GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0042391
name: regulation of membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0042392
name: sphingosine-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:8663293]
synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT []
synonym: "SPP phosphatase activity" EXACT []
synonym: "SPPase activity" EXACT []
xref: MetaCyc:RXN3DJ-25
xref: Reactome:R-HSA-428664 "SGPP1,2 dephosphorylate sphingoid-1-phosphates"
xref: Reactome:R-HSA-428690 "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate"
xref: Reactome:R-HSA-428696 "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate"
xref: RHEA:27518
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0042393
name: histone binding
namespace: molecular_function
def: "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "histone-specific chaperone activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042394
name: obsolete ecdysis, protein-based cuticle
namespace: biological_process
def: "OBSOLETE. The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "ecdysis, protein-based cuticle" EXACT []
is_obsolete: true
consider: GO:0018990
consider: GO:0042395

[Term]
id: GO:0042395
name: ecdysis, collagen and cuticulin-based cuticle
namespace: biological_process
def: "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0042396
name: phosphagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]
synonym: "phosphagen anabolism" EXACT []
synonym: "phosphagen biosynthesis" EXACT []
synonym: "phosphagen formation" EXACT []
synonym: "phosphagen synthesis" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0042397
name: phosphagen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]
synonym: "phosphagen breakdown" EXACT []
synonym: "phosphagen catabolism" EXACT []
synonym: "phosphagen degradation" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0042398
name: modified amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]
synonym: "amino acid derivative biosynthetic process" EXACT []
synonym: "cellular amino acid derivative anabolism" EXACT []
synonym: "cellular amino acid derivative biosynthesis" EXACT []
synonym: "cellular amino acid derivative biosynthetic process" EXACT []
synonym: "cellular amino acid derivative formation" EXACT []
synonym: "cellular amino acid derivative synthesis" EXACT []
synonym: "cellular modified amino acid anabolism" EXACT [GOC:mah]
synonym: "cellular modified amino acid biosynthesis" EXACT [GOC:mah]
synonym: "cellular modified amino acid formation" EXACT [GOC:mah]
synonym: "cellular modified amino acid synthesis" EXACT [GOC:mah]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0042399
name: ectoine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
synonym: "ectoine metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0042400
name: ectoine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
synonym: "ectoine breakdown" EXACT []
synonym: "ectoine catabolism" EXACT []
synonym: "ectoine degradation" EXACT []
is_a: GO:0042399 ! ectoine metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042401
name: biogenic amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
synonym: "biogenic amine anabolism" EXACT []
synonym: "biogenic amine biosynthesis" EXACT []
synonym: "biogenic amine formation" EXACT []
synonym: "biogenic amine synthesis" EXACT []
synonym: "cellular biogenic amine biosynthetic process" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0009309 ! amine biosynthetic process

[Term]
id: GO:0042402
name: biogenic amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732]
synonym: "biogenic amine breakdown" EXACT []
synonym: "biogenic amine catabolism" EXACT []
synonym: "biogenic amine degradation" EXACT []
is_a: GO:0009310 ! amine catabolic process

[Term]
id: GO:0042403
name: thyroid hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732]
synonym: "thyroid hormone metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042404
name: thyroid hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732]
synonym: "thyroid hormone breakdown" EXACT []
synonym: "thyroid hormone catabolism" EXACT []
synonym: "thyroid hormone degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0042403 ! thyroid hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0042405
name: nuclear inclusion body
namespace: cellular_component
def: "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl]
is_a: GO:0016234 ! inclusion body
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0042406
name: extrinsic component of endoplasmic reticulum membrane
namespace: cellular_component
def: "The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
synonym: "extrinsic to endoplasmic reticulum membrane" NARROW []
synonym: "extrinsic to ER membrane" EXACT []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0042407
name: cristae formation
namespace: biological_process
def: "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
is_a: GO:0007007 ! inner mitochondrial membrane organization

[Term]
id: GO:0042408
name: obsolete myrcene/(E)-beta-ocimene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382]
comment: This term was made obsolete because it represents two activities.
synonym: "myrcene/(E)-beta-ocimene synthase activity" EXACT []
synonym: "myrcene/ocimene synthase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0042409
name: caffeoyl-CoA O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104]
synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT []
synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" RELATED [EC:2.1.1.104]
synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" RELATED [EC:2.1.1.104]
xref: EC:2.1.1.104
xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN
xref: RHEA:16925
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0042410
name: 6-carboxyhexanoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H+ + pimelyl-CoA." [EC:6.2.1.14, RHEA:14781]
synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.14]
synonym: "6-carboxyhexanoyl-CoA synthetase activity" RELATED [EC:6.2.1.14]
synonym: "pimeloyl-CoA synthetase activity" RELATED [EC:6.2.1.14]
synonym: "pimelyl-CoA synthetase activity" RELATED [EC:6.2.1.14]
xref: EC:6.2.1.14
xref: KEGG_REACTION:R03209
xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN
xref: RHEA:14781
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0042412
name: taurine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
synonym: "taurine anabolism" EXACT []
synonym: "taurine biosynthesis" EXACT []
synonym: "taurine formation" EXACT []
synonym: "taurine synthesis" EXACT []
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0046305 ! alkanesulfonate biosynthetic process

[Term]
id: GO:0042413
name: carnitine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
synonym: "carnitine breakdown" EXACT []
synonym: "carnitine catabolism" EXACT []
synonym: "carnitine degradation" EXACT []
synonym: "vitamin Bt catabolic process" EXACT []
synonym: "vitamin Bt catabolism" EXACT []
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0009437 ! carnitine metabolic process

[Term]
id: GO:0042414
name: epinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]
synonym: "adrenaline metabolic process" EXACT []
synonym: "adrenaline metabolism" EXACT []
synonym: "epinephrine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042415
name: norepinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol metabolic process" EXACT []
synonym: "levarterenol metabolism" EXACT []
synonym: "noradrenaline metabolic process" EXACT []
synonym: "noradrenaline metabolism" EXACT []
synonym: "norepinephrine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042416
name: dopamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine anabolism" EXACT []
synonym: "dopamine biosynthesis" EXACT []
synonym: "dopamine formation" EXACT []
synonym: "dopamine synthesis" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042417
name: dopamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042418
name: epinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]
synonym: "adrenaline biosynthesis" EXACT []
synonym: "adrenaline biosynthetic process" EXACT []
synonym: "epinephrine anabolism" EXACT []
synonym: "epinephrine biosynthesis" EXACT []
synonym: "epinephrine formation" EXACT []
synonym: "epinephrine synthesis" EXACT []
is_a: GO:0042414 ! epinephrine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042419
name: epinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]
synonym: "adrenaline catabolic process" EXACT []
synonym: "adrenaline catabolism" EXACT []
synonym: "epinephrine breakdown" EXACT []
synonym: "epinephrine catabolism" EXACT []
synonym: "epinephrine degradation" EXACT []
is_a: GO:0042414 ! epinephrine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042420
name: dopamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine breakdown" EXACT []
synonym: "dopamine catabolism" EXACT []
synonym: "dopamine degradation" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042421
name: norepinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol biosynthesis" EXACT []
synonym: "levarterenol biosynthetic process" EXACT []
synonym: "noradrenaline biosynthesis" EXACT []
synonym: "noradrenaline biosynthetic process" EXACT []
synonym: "norepinephrine anabolism" EXACT []
synonym: "norepinephrine biosynthesis" EXACT []
synonym: "norepinephrine formation" EXACT []
synonym: "norepinephrine synthesis" EXACT []
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042422
name: norepinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol catabolic process" EXACT []
synonym: "levarterenol catabolism" EXACT []
synonym: "noradrenaline catabolic process" EXACT []
synonym: "noradrenaline catabolism" EXACT []
synonym: "norepinephrine breakdown" EXACT []
synonym: "norepinephrine catabolism" EXACT []
synonym: "norepinephrine degradation" EXACT []
xref: Wikipedia:Norepinephrine#Degradation
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042423
name: catecholamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine anabolism" EXACT []
synonym: "catecholamine biosynthesis" EXACT []
synonym: "catecholamine formation" EXACT []
synonym: "catecholamine synthesis" EXACT []
xref: Wikipedia:Catecholamines
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0042401 ! biogenic amine biosynthetic process

[Term]
id: GO:0042424
name: catecholamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine breakdown" EXACT []
synonym: "catecholamine catabolism" EXACT []
synonym: "catecholamine degradation" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0042402 ! biogenic amine catabolic process

[Term]
id: GO:0042425
name: choline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
synonym: "choline anabolism" EXACT []
synonym: "choline biosynthesis" EXACT []
synonym: "choline formation" EXACT []
synonym: "choline synthesis" EXACT []
xref: MetaCyc:PWY-4762
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0042401 ! biogenic amine biosynthetic process

[Term]
id: GO:0042426
name: choline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
synonym: "choline breakdown" EXACT []
synonym: "choline catabolism" EXACT []
synonym: "choline degradation" EXACT []
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0042402 ! biogenic amine catabolic process

[Term]
id: GO:0042427
name: serotonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin anabolism" EXACT []
synonym: "serotonin biosynthesis" EXACT []
synonym: "serotonin formation" EXACT []
synonym: "serotonin synthesis" EXACT []
xref: Wikipedia:Serotonin
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0042428
name: serotonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0042429
name: serotonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin breakdown" EXACT []
synonym: "serotonin catabolism" EXACT []
synonym: "serotonin degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0042430
name: indole-containing compound metabolic process
namespace: biological_process
alt_id: GO:0042434
def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah]
synonym: "indole and derivative metabolic process" EXACT []
synonym: "indole and derivative metabolism" EXACT []
synonym: "indole derivative metabolic process" NARROW []
synonym: "indole derivative metabolism" NARROW []
synonym: "indole-containing compound metabolism" EXACT []
synonym: "ketole metabolic process" EXACT []
synonym: "ketole metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042431
name: indole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl]
synonym: "indole metabolism" EXACT []
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0042432
name: indole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl]
synonym: "indole anabolism" EXACT []
synonym: "indole biosynthesis" EXACT []
synonym: "indole formation" EXACT []
synonym: "indole synthesis" EXACT []
is_a: GO:0042431 ! indole metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process

[Term]
id: GO:0042433
name: indole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl]
synonym: "indole breakdown" EXACT []
synonym: "indole catabolism" EXACT []
synonym: "indole degradation" EXACT []
is_a: GO:0042431 ! indole metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process

[Term]
id: GO:0042435
name: indole-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl]
synonym: "indole derivative biosynthesis" EXACT []
synonym: "indole derivative biosynthetic process" EXACT []
synonym: "indole-containing compound anabolism" EXACT []
synonym: "indole-containing compound biosynthesis" EXACT []
synonym: "indole-containing compound formation" EXACT []
synonym: "indole-containing compound synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0042436
name: indole-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl]
synonym: "indole derivative catabolic process" EXACT []
synonym: "indole derivative catabolism" EXACT []
synonym: "indole-containing compound breakdown" EXACT []
synonym: "indole-containing compound catabolism" EXACT []
synonym: "indole-containing compound degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0042437
name: indoleacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl]
synonym: "IAA catabolic process" EXACT []
synonym: "indole acetic acid catabolic process" EXACT []
synonym: "indole acetic acid catabolism" EXACT []
synonym: "indoleacetic acid breakdown" EXACT []
synonym: "indoleacetic acid catabolism" EXACT []
synonym: "indoleacetic acid degradation" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process
is_a: GO:0009852 ! auxin catabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042438
name: melanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:curators]
synonym: "melanin anabolism" EXACT []
synonym: "melanin biosynthesis" EXACT []
synonym: "melanin formation" EXACT []
synonym: "melanin synthesis" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0042439
name: ethanolamine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [GOC:mah]
synonym: "ethanolamine and derivative metabolic process" EXACT []
synonym: "ethanolamine and derivative metabolism" EXACT []
synonym: "ethanolamine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006576 ! biogenic amine metabolic process

[Term]
id: GO:0042440
name: pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_pir
synonym: "pigment metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042441
name: eye pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment metabolism" EXACT []
is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation
relationship: part_of GO:0048069 ! eye pigmentation

[Term]
id: GO:0042442
name: melatonin catabolic process
namespace: biological_process
alt_id: GO:0042449
def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl]
synonym: "melatonin breakdown" EXACT []
synonym: "melatonin catabolism" EXACT []
synonym: "melatonin degradation" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0042443
name: phenylethylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine metabolism" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0042444
name: phenylethylamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine anabolism" EXACT []
synonym: "phenylethylamine biosynthesis" EXACT []
synonym: "phenylethylamine formation" EXACT []
synonym: "phenylethylamine synthesis" EXACT []
is_a: GO:0042401 ! biogenic amine biosynthetic process
is_a: GO:0042443 ! phenylethylamine metabolic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0042445
name: hormone metabolic process
namespace: biological_process
alt_id: GO:0034754
def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]
subset: goslim_pir
synonym: "cellular hormone metabolic process" RELATED []
synonym: "hormone metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0042446
name: hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]
synonym: "hormone anabolism" EXACT []
synonym: "hormone biosynthesis" EXACT []
synonym: "hormone formation" EXACT []
synonym: "hormone synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042447
name: hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]
synonym: "hormone breakdown" EXACT []
synonym: "hormone catabolism" EXACT []
synonym: "hormone degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042448
name: progesterone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, PMID:11392024]
synonym: "progesterone metabolism" EXACT []
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0042450
name: arginine biosynthetic process via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]
synonym: "arginine anabolism via ornithine" EXACT []
synonym: "arginine formation via ornithine" EXACT []
synonym: "arginine synthesis via ornithine" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0042451
name: purine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]
synonym: "purine nucleoside anabolism" EXACT []
synonym: "purine nucleoside biosynthesis" EXACT []
synonym: "purine nucleoside formation" EXACT []
synonym: "purine nucleoside synthesis" EXACT []
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0042278 ! purine nucleoside metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0042452
name: deoxyguanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl]
synonym: "deoxyguanosine anabolism" EXACT []
synonym: "deoxyguanosine biosynthesis" EXACT []
synonym: "deoxyguanosine formation" EXACT []
synonym: "deoxyguanosine synthesis" EXACT []
is_a: GO:0042453 ! deoxyguanosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0042453
name: deoxyguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl]
synonym: "deoxyguanosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0042454
name: ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl]
synonym: "ribonucleoside breakdown" EXACT []
synonym: "ribonucleoside catabolism" EXACT []
synonym: "ribonucleoside degradation" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process

[Term]
id: GO:0042455
name: ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl]
synonym: "ribonucleoside anabolism" EXACT []
synonym: "ribonucleoside biosynthesis" EXACT []
synonym: "ribonucleoside formation" EXACT []
synonym: "ribonucleoside synthesis" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process

[Term]
id: GO:0042457
name: ethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845]
synonym: "ethene catabolic process" EXACT []
synonym: "ethene catabolism" EXACT []
synonym: "ethylene breakdown" EXACT []
synonym: "ethylene catabolism" EXACT []
synonym: "ethylene degradation" EXACT []
is_a: GO:0009692 ! ethylene metabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042458
name: obsolete nopaline catabolic process to proline
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "nopaline breakdown to proline" EXACT []
synonym: "nopaline degradation to proline" EXACT []
is_obsolete: true

[Term]
id: GO:0042459
name: obsolete octopine catabolic process to proline
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "octopine breakdown to proline" EXACT []
synonym: "octopine degradation to proline" EXACT []
is_obsolete: true

[Term]
id: GO:0042461
name: photoreceptor cell development
namespace: biological_process
alt_id: GO:0046531
def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators]
synonym: "photoreceptor morphogenesis" EXACT []
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0042462
name: eye photoreceptor cell development
namespace: biological_process
def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]
is_a: GO:0042461 ! photoreceptor cell development
relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation

[Term]
id: GO:0042463
name: ocellus photoreceptor cell development
namespace: biological_process
alt_id: GO:0001749
def: "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766]
synonym: "non-eye photoreceptor development" BROAD []
is_a: GO:0042461 ! photoreceptor cell development
relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation

[Term]
id: GO:0042464
name: dosage compensation by hypoactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mr, PMID:11102361]
xref: Wikipedia:XY_sex-determination_system
is_a: GO:0007549 ! sex-chromosome dosage compensation

[Term]
id: GO:0042465
name: kinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023]
xref: Wikipedia:Kinesis
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0042466
name: chemokinesis
namespace: biological_process
def: "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, PMID:2073411]
xref: Wikipedia:Chemokinesis
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042467
name: orthokinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, PMID:8207088]
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042468
name: klinokinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, PMID:2790068]
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042469
name: versicolorin reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [PMID:1339261]
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0042470
name: melanosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]
xref: Wikipedia:Melanosome
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0042471
name: ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]
synonym: "hearing organ morphogenesis" EXACT []
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043583 ! ear development

[Term]
id: GO:0042472
name: inner ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0042473
name: outer ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis

[Term]
id: GO:0042474
name: middle ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis

[Term]
id: GO:0042475
name: odontogenesis of dentin-containing tooth
namespace: biological_process
def: "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]
comment: Note that placoid scales found in the cartilaginous fishes presumably develop through the same processes, but are found on the dermis, rather than in the mouth or pharynx. See Wikipedia:Placoid_scale#Placoid_scales.
synonym: "odontogenesis of dentine-containing teeth" EXACT []
synonym: "odontogenesis of dentine-containing tooth" EXACT [GOC:mah]
synonym: "odontogeny" BROAD []
synonym: "odontosis" BROAD []
synonym: "tooth development" BROAD []
is_a: GO:0042476 ! odontogenesis

[Term]
id: GO:0042476
name: odontogenesis
namespace: biological_process
alt_id: GO:0042477
def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah]
synonym: "odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "odontogeny" EXACT []
synonym: "odontosis" EXACT []
synonym: "tooth development" RELATED []
synonym: "tooth morphogenesis" EXACT []
xref: Wikipedia:Odontogenesis
is_a: GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0042478
name: regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "regulation of eye photoreceptor development" EXACT []
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042479
name: positive regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "activation of eye photoreceptor cell development" NARROW []
synonym: "positive regulation of eye photoreceptor development" EXACT []
synonym: "stimulation of eye photoreceptor cell development" NARROW []
synonym: "up regulation of eye photoreceptor cell development" EXACT []
synonym: "up-regulation of eye photoreceptor cell development" EXACT []
synonym: "upregulation of eye photoreceptor cell development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042480
name: negative regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "down regulation of eye photoreceptor cell development" EXACT []
synonym: "down-regulation of eye photoreceptor cell development" EXACT []
synonym: "downregulation of eye photoreceptor cell development" EXACT []
synonym: "inhibition of eye photoreceptor cell development" NARROW []
synonym: "negative regulation of eye photoreceptor development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042481
name: regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042484
def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "regulation of tooth development" EXACT []
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042482
name: positive regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042485
def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "activation of odontogenesis" NARROW []
synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "positive regulation of tooth development" EXACT []
synonym: "stimulation of odontogenesis" NARROW []
synonym: "up regulation of odontogenesis" EXACT []
synonym: "up-regulation of odontogenesis" EXACT []
synonym: "upregulation of odontogenesis" EXACT []
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
relationship: positively_regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042483
name: negative regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042486
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "down regulation of odontogenesis" EXACT []
synonym: "down-regulation of odontogenesis" EXACT []
synonym: "downregulation of odontogenesis" EXACT []
synonym: "inhibition of odontogenesis" NARROW []
synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "negative regulation of tooth development" EXACT []
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0110111 ! negative regulation of animal organ morphogenesis
relationship: negatively_regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042487
name: regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, PMID:15355794]
synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT []
synonym: "regulation of odontogenesis of dentine-containing tooth" EXACT [GOC:mah]
is_a: GO:0042481 ! regulation of odontogenesis
relationship: regulates GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0042488
name: positive regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, PMID:15355794]
synonym: "activation of odontogenesis" BROAD []
synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT []
synonym: "positive regulation of odontogenesis of dentine-containing tooth" RELATED []
synonym: "stimulation of odontogenesis" BROAD []
synonym: "up regulation of odontogenesis" BROAD []
synonym: "up-regulation of odontogenesis" BROAD []
synonym: "upregulation of odontogenesis" BROAD []
is_a: GO:0042482 ! positive regulation of odontogenesis
is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth
relationship: positively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0042489
name: negative regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, PMID:15355794]
synonym: "down regulation of odontogenesis" BROAD []
synonym: "down-regulation of odontogenesis" BROAD []
synonym: "downregulation of odontogenesis" BROAD []
synonym: "inhibition of odontogenesis" BROAD []
synonym: "negative regulation of odontogenesis" BROAD []
synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT []
synonym: "negative regulation of odontogenesis of dentine-containing tooth" RELATED []
is_a: GO:0042483 ! negative regulation of odontogenesis
is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth
relationship: negatively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0042490
name: mechanoreceptor differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [CL:0000199, GOC:jl]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0042491
name: inner ear auditory receptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell." [CL:0000201, GOC:jl]
comment: Note that this term refers to the mechanosensory hair cells of the inner ear.
synonym: "auditory hair cell differentiation" EXACT []
synonym: "auditory receptor cell differentiation" RELATED []
is_a: GO:0035315 ! hair cell differentiation
is_a: GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0042492
name: gamma-delta T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." [CL:0000798, GOC:jl]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta T cell development" RELATED [GOC:add]
synonym: "gamma-delta T lymphocyte differentiation" EXACT []
synonym: "gamma-delta T-cell differentiation" EXACT []
synonym: "gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0042494
name: detection of bacterial lipoprotein
namespace: biological_process
def: "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222]
synonym: "detection of BLP" RELATED []
synonym: "detection of Lpp" RELATED []
synonym: "perception of bacterial lipoprotein" RELATED []
synonym: "perception of BLP" RELATED []
synonym: "perception of Lpp" RELATED []
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032493 ! response to bacterial lipoprotein
relationship: part_of GO:0016045 ! detection of bacterium

[Term]
id: GO:0042495
name: detection of triacyl bacterial lipopeptide
namespace: biological_process
def: "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "detection of triacylated bacterial lipoprotein" EXACT [GOC:add]
synonym: "perception of triacylated bacterial lipopeptide" RELATED [GOC:add]
synonym: "perception of triacylated bacterial lipoprotein" RELATED []
is_a: GO:0070340 ! detection of bacterial lipopeptide
is_a: GO:0071725 ! response to triacyl bacterial lipopeptide

[Term]
id: GO:0042496
name: detection of diacyl bacterial lipopeptide
namespace: biological_process
def: "The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "detection of diacylated bacterial lipoprotein" EXACT [GOC:add]
synonym: "perception of diacylated bacterial lipopeptide" RELATED [GOC:add]
synonym: "perception of diacylated bacterial lipoprotein" RELATED []
is_a: GO:0070340 ! detection of bacterial lipopeptide
is_a: GO:0071724 ! response to diacyl bacterial lipopeptide

[Term]
id: GO:0042497
name: triacyl lipopeptide binding
namespace: molecular_function
def: "Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "bacterial triacyl lipopeptide binding" NARROW [GOC:add]
synonym: "bacterial triacyl lipoprotein binding" RELATED [GOC:add]
synonym: "triacylated lipopeptide binding" EXACT []
is_a: GO:0071723 ! lipopeptide binding

[Term]
id: GO:0042498
name: diacyl lipopeptide binding
namespace: molecular_function
def: "Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "bacterial diacyl lipopeptide binding" NARROW [GOC:add]
synonym: "bacterial diacyl lipoprotein binding" RELATED [GOC:add]
synonym: "diacylated lipopeptide binding" EXACT []
is_a: GO:0071723 ! lipopeptide binding

[Term]
id: GO:0042499
name: obsolete signal peptide peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416]
comment: This term was made obsolete because it represents a gene product.
synonym: "signal peptide peptidase activity" EXACT []
synonym: "SPP" EXACT []
is_obsolete: true
replaced_by: GO:0042500

[Term]
id: GO:0042500
name: aspartic endopeptidase activity, intramembrane cleaving
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]
comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
xref: Reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)"
xref: Reactome:R-HSA-9708457 "HM13 cleaves HMOX1 dimer"
is_a: GO:0004190 ! aspartic-type endopeptidase activity

[Term]
id: GO:0042501
name: serine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:0033136
def: "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]
subset: gocheck_obsoletion_candidate
synonym: "serine phosphorylation of STAT3 protein" NARROW []
is_a: GO:0018105 ! peptidyl-serine phosphorylation
relationship: part_of GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT

[Term]
id: GO:0042509
name: regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:0042510
alt_id: GO:0042513
alt_id: GO:0042516
alt_id: GO:0042519
alt_id: GO:0042522
alt_id: GO:0042525
alt_id: GO:0042528
def: "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
subset: gocheck_obsoletion_candidate
synonym: "regulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "regulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "regulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "regulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "regulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "regulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "regulation of tyrosine phosphorylation of Stat7 protein" NARROW []
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042531
name: positive regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:0042511
alt_id: GO:0042515
alt_id: GO:0042517
alt_id: GO:0042520
alt_id: GO:0042523
alt_id: GO:0042526
alt_id: GO:0042529
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
subset: gocheck_obsoletion_candidate
synonym: "activation of tyrosine phosphorylation of STAT protein" NARROW []
synonym: "activation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "activation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "activation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "activation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "activation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "activation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "activation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "positive regulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "positive regulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "positive regulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "positive regulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "positive regulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "positive regulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "positive regulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of STAT protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "up regulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "up-regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "up-regulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "up-regulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "up-regulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "up-regulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "up-regulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "up-regulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "upregulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "upregulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "upregulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "upregulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "upregulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "upregulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "upregulation of tyrosine phosphorylation of Stat7 protein" NARROW []
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
relationship: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042532
name: negative regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
alt_id: GO:0042512
alt_id: GO:0042514
alt_id: GO:0042518
alt_id: GO:0042521
alt_id: GO:0042524
alt_id: GO:0042527
alt_id: GO:0042530
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "down regulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "down regulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "down regulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "down regulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "down regulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "down regulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "down regulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of STAT protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of Stat7 protein" NARROW []
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
is_a: GO:0046426 ! negative regulation of receptor signaling pathway via JAK-STAT
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
relationship: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042537
name: benzene-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [GOC:jl]
synonym: "benzene and derivative metabolic process" EXACT []
synonym: "benzene and derivative metabolism" EXACT []
synonym: "benzene-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042538
name: hyperosmotic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
synonym: "response to hyperosmotic salt stress" EXACT []
synonym: "salt tolerance" RELATED []
is_a: GO:0006972 ! hyperosmotic response
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0042539
name: hypotonic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
synonym: "response to hypotonic salt stress" EXACT []
is_a: GO:0006971 ! hypotonic response
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0042540
name: hemoglobin catabolic process
namespace: biological_process
alt_id: GO:0020029
def: "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [GOC:jl, GOC:mb]
comment: Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process.
synonym: "haemoglobin catabolic process" EXACT []
synonym: "haemoglobin catabolism" EXACT []
synonym: "haemoglobin hydrolysis" NARROW []
synonym: "hemoglobin breakdown" EXACT []
synonym: "hemoglobin catabolism" EXACT []
synonym: "hemoglobin degradation" EXACT []
synonym: "hemoglobin hydrolysis" NARROW []
is_a: GO:0020027 ! hemoglobin metabolic process
is_a: GO:0030163 ! protein catabolic process

[Term]
id: GO:0042541
name: hemoglobin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl]
synonym: "haemoglobin biosynthesis" EXACT []
synonym: "haemoglobin biosynthetic process" EXACT []
synonym: "hemoglobin anabolism" EXACT []
synonym: "hemoglobin biosynthesis" EXACT []
synonym: "hemoglobin formation" EXACT []
synonym: "hemoglobin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0020027 ! hemoglobin metabolic process

[Term]
id: GO:0042542
name: response to hydrogen peroxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0042543
name: obsolete protein N-linked glycosylation via arginine
namespace: biological_process
def: "OBSOLETE. The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327]
comment: The reason for obsoletion is that these term were added in error
is_obsolete: true
replaced_by: GO:0006487

[Term]
id: GO:0042544
name: melibiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732]
synonym: "melibiose anabolism" EXACT []
synonym: "melibiose biosynthesis" EXACT []
synonym: "melibiose formation" EXACT []
synonym: "melibiose synthesis" EXACT []
is_a: GO:0005994 ! melibiose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0042545
name: cell wall modification
namespace: biological_process
def: "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl]
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0042546
name: cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732]
synonym: "cell wall assembly" NARROW []
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0042547
name: cell wall modification involved in multidimensional cell growth
namespace: biological_process
def: "The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth." [GOC:dph, GOC:jl, GOC:tb]
synonym: "cell wall modification during cell expansion" EXACT []
synonym: "cell wall modification during multidimensional cell growth" RELATED [GOC:dph, GOC:tb]
is_a: GO:0042545 ! cell wall modification
relationship: part_of GO:0009825 ! multidimensional cell growth

[Term]
id: GO:0042548
name: regulation of photosynthesis, light reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0042549
name: photosystem II stabilization
namespace: biological_process
def: "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]
is_a: GO:0042548 ! regulation of photosynthesis, light reaction

[Term]
id: GO:0042550
name: photosystem I stabilization
namespace: biological_process
def: "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]
is_a: GO:0042548 ! regulation of photosynthesis, light reaction

[Term]
id: GO:0042551
name: neuron maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0042552
name: myelination
namespace: biological_process
def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah]
synonym: "myelinogenesis" RELATED [GOC:cjm, HP:0003429]
xref: Wikipedia:Myelin
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0042554
name: superoxide anion generation
namespace: biological_process
def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]
synonym: "superoxide release" EXACT [GOC:hjd, GOC:mah]
is_a: GO:0006801 ! superoxide metabolic process

[Term]
id: GO:0042555
name: MCM complex
namespace: cellular_component
def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]
synonym: "mini-chromosome maintenance complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0042556
name: eukaryotic elongation factor-2 kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]
synonym: "eEF-2 kinase regulator" EXACT []
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0042557
name: eukaryotic elongation factor-2 kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]
synonym: "eEF-2 kinase activator" EXACT []
is_a: GO:0042556 ! eukaryotic elongation factor-2 kinase regulator activity
is_a: GO:0043539 ! protein serine/threonine kinase activator activity

[Term]
id: GO:0042558
name: pteridine-containing compound metabolic process
namespace: biological_process
alt_id: GO:0019721
def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]
synonym: "pteridine and derivative metabolic process" EXACT []
synonym: "pteridine and derivative metabolism" EXACT []
synonym: "pteridine-containing compound metabolism" EXACT []
synonym: "pterin metabolic process" NARROW []
synonym: "pterin metabolism" NARROW []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042559
name: pteridine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]
subset: goslim_pombe
synonym: "pteridine and derivative biosynthesis" EXACT []
synonym: "pteridine and derivative biosynthetic process" EXACT []
synonym: "pteridine-containing compound anabolism" EXACT []
synonym: "pteridine-containing compound biosynthesis" EXACT []
synonym: "pteridine-containing compound formation" EXACT []
synonym: "pteridine-containing compound synthesis" EXACT []
synonym: "pterin biosynthesis" NARROW []
synonym: "pterin biosynthetic process" NARROW []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0042560
name: pteridine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]
synonym: "pteridine and derivative catabolic process" EXACT []
synonym: "pteridine and derivative catabolism" EXACT []
synonym: "pteridine-containing compound breakdown" EXACT []
synonym: "pteridine-containing compound catabolism" EXACT []
synonym: "pteridine-containing compound degradation" EXACT []
synonym: "pterin catabolic process" NARROW []
synonym: "pterin catabolism" NARROW []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0042561
name: alpha-amyrin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin." [GOC:jl, MetaCyc:RXN-8434, PMID:10848960]
xref: MetaCyc:RXN-8434
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042562
name: hormone binding
namespace: molecular_function
def: "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042563
name: obsolete importin alpha-subunit nuclear export complex
namespace: cellular_component
def: "OBSOLETE. A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to transport the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]
comment: The reason for obsoletion is that these terms include the substrate of the reaction.
is_obsolete: true

[Term]
id: GO:0042564
name: NLS-dependent protein nuclear import complex
namespace: cellular_component
def: "A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134, Wikipedia:Importin]
is_a: GO:0031074 ! nucleocytoplasmic transport complex

[Term]
id: GO:0042565
name: RNA nuclear export complex
namespace: cellular_component
def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123]
is_a: GO:0031074 ! nucleocytoplasmic transport complex

[Term]
id: GO:0042566
name: hydrogenosome
namespace: cellular_component
def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569]
subset: goslim_pir
xref: Wikipedia:Hydrogenosome
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0042567
name: insulin-like growth factor ternary complex
namespace: cellular_component
def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
synonym: "IGF ternary complex" EXACT []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042568
name: insulin-like growth factor binary complex
namespace: cellular_component
def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
synonym: "IGF binary complex" EXACT []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042571
name: immunoglobulin complex, circulating
namespace: cellular_component
def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "antibody" EXACT [GOC:add]
xref: Wikipedia:Antibody
is_a: GO:0019814 ! immunoglobulin complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0042572
name: retinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, PMID:1924551]
synonym: "retinol metabolism" EXACT []
synonym: "vitamin A1 alcohol metabolic process" EXACT []
synonym: "vitamin A1 alcohol metabolism" EXACT []
synonym: "vitamin A1 metabolic process" EXACT []
synonym: "vitamin A1 metabolism" EXACT []
xref: Wikipedia:Retinol
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0042573
name: retinoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, PMID:12570742]
synonym: "retinoic acid metabolism" EXACT []
synonym: "vitamin A1 acid metabolic process" EXACT []
synonym: "vitamin A1 acid metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042574
name: retinal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [ISBN:0198506732]
synonym: "retinal metabolism" EXACT []
synonym: "retinaldehyde metabolic process" EXACT []
synonym: "retinaldehyde metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0042575
name: DNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093]
subset: goslim_metagenomics
subset: goslim_pir
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0042576
name: obsolete aspartyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [GOC:curator]
comment: This term was made obsolete because it represents a gene product.
synonym: "aspartyl aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0042577
name: lipid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0042578
name: phosphoric ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0042579
name: microbody
namespace: cellular_component
def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732]
subset: goslim_pir
xref: Wikipedia:Microbody
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0042580
name: mannosome
namespace: cellular_component
def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531]
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0042581
name: specific granule
namespace: cellular_component
def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, ISBN:0721662544, PMID:7334549]
synonym: "secondary granule" EXACT []
xref: Wikipedia:Specific_granule
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042582
name: azurophil granule
namespace: cellular_component
def: "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule]
synonym: "primary granule" EXACT []
is_a: GO:0005766 ! primary lysosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042583
name: chromaffin granule
namespace: cellular_component
def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, PMID:19158310, PMID:1961743]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042584
name: chromaffin granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042583 ! chromaffin granule

[Term]
id: GO:0042585
name: germinal vesicle
namespace: cellular_component
def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837]
synonym: "primary oocyte nucleus" EXACT []
is_a: GO:0001674 ! female germ cell nucleus

[Term]
id: GO:0042586
name: peptide deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl]
synonym: "formyl-L-methionyl peptide amidohydrolase activity" RELATED [EC:3.5.1.88]
synonym: "PDF activity" RELATED [EC:3.5.1.88]
synonym: "polypeptide deformylase activity" RELATED [EC:3.5.1.88]
xref: EC:3.5.1.88
xref: MetaCyc:3.5.1.88-RXN
xref: RHEA:24420
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0042587
name: glycogen granule
namespace: cellular_component
def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, PMID:12179957]
synonym: "glycogen particle" EXACT []
xref: NIF_Subcellular:sao1081228141
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0042588
name: zymogen granule
namespace: cellular_component
def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042589
name: zymogen granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042588 ! zymogen granule

[Term]
id: GO:0042590
name: antigen processing and presentation of exogenous peptide antigen via MHC class I
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT []
synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT []
synonym: "cross presentation" BROAD []
synonym: "cross priming" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "cross-priming" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen

[Term]
id: GO:0042592
name: homeostatic process
namespace: biological_process
alt_id: GO:0032844
alt_id: GO:0032845
alt_id: GO:0032846
def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_mouse
synonym: "activation of homeostatic process" NARROW []
synonym: "homeostasis" EXACT []
synonym: "inhibition of homeostatic process" NARROW []
synonym: "negative regulation of homeostatic process" RELATED []
synonym: "positive regulation of homeostatic process" RELATED []
synonym: "regulation of homeostatic process" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042593
name: glucose homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]
is_a: GO:0033500 ! carbohydrate homeostasis

[Term]
id: GO:0042594
name: response to starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
subset: goslim_yeast
is_a: GO:0006950 ! response to stress
is_a: GO:0031667 ! response to nutrient levels

[Term]
id: GO:0042595
name: behavioral response to starvation
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
synonym: "behavioural response to starvation" EXACT []
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0042596
name: fear response
namespace: biological_process
alt_id: GO:0001663
def: "The response of an organism to a perceived external threat." [GOC:go_curators]
synonym: "physiological fear response" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0042597
name: periplasmic space
namespace: cellular_component
alt_id: GO:0005620
def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "periplasm" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0042598
name: obsolete vesicular fraction
namespace: cellular_component
def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "vesicular fraction" EXACT []
is_obsolete: true
consider: GO:0031982

[Term]
id: GO:0042599
name: lamellar body
namespace: cellular_component
def: "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:cjm, GOC:jl, PMID:12243725, Wikipedia:Lamellar_granule]
synonym: "keratinosome" NARROW []
synonym: "lamellar granule" EXACT []
synonym: "membrane-coating granule" EXACT []
synonym: "Odland body" NARROW []
xref: NIF_Subcellular:sao1379604862
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042600
name: egg chorion
namespace: cellular_component
def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO.
subset: goslim_pir
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0042601
name: endospore-forming forespore
namespace: cellular_component
def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029]
is_a: GO:0042763 ! intracellular immature spore

[Term]
id: GO:0042602
name: riboflavin reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+." [RHEA:19377]
synonym: "flavin reductase activity" RELATED [EC:1.5.1.30]
synonym: "FMN reductase (NADPH) activity" RELATED [EC:1.5.1.30]
synonym: "NADPH dehydrogenase (riboflavin) activity" RELATED [EC:1.5.1.30]
synonym: "NADPH-dependent FMN reductase activity" RELATED [EC:1.5.1.30]
synonym: "NADPH-FMN reductase activity" RELATED [EC:1.5.1.30]
synonym: "NADPH-riboflavin oxidoreductase activity" EXACT []
synonym: "NADPH-riboflavin reductase activity" RELATED [EC:1.5.1.30]
synonym: "NADPH-specific FMN reductase activity" RELATED [EC:1.5.1.30]
synonym: "NADPH:riboflavin oxidoreductase activity" RELATED [EC:1.5.1.30]
synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.30]
synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.5.1.30]
synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30]
synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30]
xref: EC:1.5.1.30
xref: KEGG_REACTION:R05707
xref: MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN
xref: RHEA:19377
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042603
name: capsule
namespace: cellular_component
alt_id: GO:0030113
alt_id: GO:0042604
def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherence, and resistance to desiccation." [GOC:mlg]
xref: Wikipedia:Capsule_(microbiology)
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0042605
name: peptide antigen binding
namespace: molecular_function
alt_id: GO:0042606
alt_id: GO:0042607
def: "Binding to an antigen peptide." [GOC:add, GOC:jl, GOC:rv]
comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule.
subset: goslim_chembl
synonym: "endogenous peptide antigen binding" NARROW []
synonym: "exogenous peptide antigen binding" NARROW []
is_a: GO:0003823 ! antigen binding
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0042608
name: T cell receptor binding
namespace: molecular_function
def: "Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl]
synonym: "T lymphocyte receptor binding" EXACT []
synonym: "T-cell receptor binding" EXACT []
synonym: "T-lymphocyte receptor binding" EXACT []
synonym: "TCR binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0042609
name: CD4 receptor binding
namespace: molecular_function
def: "Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MSH:D015704]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0042610
name: CD8 receptor binding
namespace: molecular_function
def: "Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MSH:D016827]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]
subset: goslim_pir
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0042612
name: MHC class I protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]
comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'.
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042614
name: CD70 receptor binding
namespace: molecular_function
def: "Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859]
synonym: "CD27 receptor activity" RELATED []
synonym: "CD27L binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0042615
name: CD154 receptor binding
namespace: molecular_function
def: "Binding to CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859]
synonym: "CD40 receptor activity" RELATED []
synonym: "CD40L binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0042617
name: paclitaxel biosynthetic process
namespace: biological_process
alt_id: GO:0042616
def: "The chemical reactions and pathways resulting in the formation of paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia." [GOC:jl, GOC:krc]
synonym: "paclitaxel anabolism" EXACT []
synonym: "paclitaxel biosynthesis" EXACT []
synonym: "paclitaxel formation" EXACT []
synonym: "paclitaxel metabolic process" BROAD []
synonym: "paclitaxel metabolism" BROAD []
synonym: "paclitaxel synthesis" EXACT []
synonym: "taxol biosynthesis" NARROW []
synonym: "taxol biosynthetic process" NARROW []
synonym: "taxol metabolic process" BROAD []
synonym: "taxol metabolism" BROAD []
is_a: GO:0016102 ! diterpenoid biosynthetic process

[Term]
id: GO:0042618
name: poly-hydroxybutyrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, PMID:18640095]
synonym: "PHB metabolic process" EXACT []
synonym: "PHB metabolism" EXACT []
synonym: "poly-hydroxybutyrate metabolism" EXACT []
is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process

[Term]
id: GO:0042619
name: poly-hydroxybutyrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, PMID:18640095]
synonym: "PHB biosynthesis" EXACT []
synonym: "PHB biosynthetic process" EXACT []
synonym: "poly-hydroxybutyrate anabolism" EXACT []
synonym: "poly-hydroxybutyrate biosynthesis" EXACT []
synonym: "poly-hydroxybutyrate formation" EXACT []
synonym: "poly-hydroxybutyrate synthesis" EXACT []
is_a: GO:0042618 ! poly-hydroxybutyrate metabolic process
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process

[Term]
id: GO:0042620
name: poly(3-hydroxyalkanoate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]
subset: goslim_pir
synonym: "PHA metabolic process" BROAD []
synonym: "PHA metabolism" BROAD []
synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042621
name: poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]
synonym: "PHA biosynthesis" BROAD []
synonym: "PHA biosynthetic process" BROAD []
synonym: "poly(3-hydroxyalkanoate) anabolism" EXACT []
synonym: "poly(3-hydroxyalkanoate) biosynthesis" EXACT []
synonym: "poly(3-hydroxyalkanoate) formation" EXACT []
synonym: "poly(3-hydroxyalkanoate) synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042620 ! poly(3-hydroxyalkanoate) metabolic process

[Term]
id: GO:0042622
name: photoreceptor outer segment membrane
namespace: cellular_component
def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl]
is_a: GO:0060170 ! ciliary membrane
relationship: part_of GO:0001750 ! photoreceptor outer segment

[Term]
id: GO:0042624
name: obsolete ATPase activity, uncoupled
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction." [PMID:12912988]
comment: The reason for obsoletion is that the there is no convincing example of a protein with this function.
is_obsolete: true

[Term]
id: GO:0042625
name: ATPase-coupled ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
synonym: "ATP-dependent ion transmembrane transporter activity" EXACT []
synonym: "ATPase activity, coupled to transmembrane movement of ions" EXACT []
synonym: "ATPase coupled ion transmembrane transporter activity" EXACT []
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0042626
name: ATPase-coupled transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015405
alt_id: GO:0016820
alt_id: GO:0043492
def: "Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ATP-coupled transmembrane transporter activity" EXACT []
synonym: "ATP-dependent transmembrane transporter activity" EXACT []
synonym: "ATPase activity, coupled to movement of substances" BROAD []
synonym: "ATPase activity, coupled to transmembrane movement of substances" EXACT []
synonym: "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" NARROW []
synonym: "P-P-bond-hydrolysis-driven transmembrane transporter activity" BROAD []
synonym: "P-P-bond-hydrolysis-driven transporter" BROAD []
xref: EC:7.2.2.-
xref: Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region"
xref: Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
xref: Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
xref: Reactome:R-HSA-390393 "Peroxisomal uptake of very long-chain fatty acyl CoA"
xref: Reactome:R-HSA-9033499 "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol"
xref: Reactome:R-HSA-9033505 "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12"
xref: Reactome:R-HSA-9659680 "ABCB1 transports xenobiotics out of the cell"
xref: Reactome:R-HSA-9750546 "ABCC4 transports TPMP substrates from cytosol to extracellular region"
xref: Reactome:R-HSA-9750617 "ABCC5 transports TPMP substrates from cytosol to extracellular region"
xref: Reactome:R-HSA-9753278 "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3"
xref: Reactome:R-HSA-9753283 "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3"
xref: Reactome:R-HSA-9753284 "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region"
xref: Reactome:R-HSA-9759454 "ABCB1 transports PREDN,PREDL out of kidney cells"
xref: Reactome:R-HSA-9759461 "ABCB1 transports PREDN,PREDL out of hepatic cells"
xref: Reactome:R-HSA-9794120 "ABCG2 transports Cipro from intestinal cell to extracellular space"
xref: Reactome:R-HSA-9794572 "ABCG2 transports Cipro from hepatic cell to extracellular space"
is_a: GO:0015399 ! primary active transmembrane transporter activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0042627
name: chylomicron
namespace: cellular_component
def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, PMID:10580165]
xref: Wikipedia:Chylomicron
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0042628
name: mating plug formation
namespace: biological_process
def: "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, PMID:11267893]
synonym: "copulatory plug biosynthesis" EXACT []
synonym: "copulatory plug deposition" EXACT []
synonym: "copulatory plug formation" EXACT []
synonym: "mating plug deposition" EXACT []
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0042629
name: mast cell granule
namespace: cellular_component
def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, PMID:12360215]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0042630
name: behavioral response to water deprivation
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of deprivation of water." [GOC:jl]
synonym: "behavioral response to drought" EXACT []
synonym: "behavioral response to thirst" EXACT []
synonym: "behavioural response to water deprivation" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0009414 ! response to water deprivation

[Term]
id: GO:0042631
name: cellular response to water deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators]
synonym: "cellular response to drought" EXACT []
is_a: GO:0009414 ! response to water deprivation
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0071462 ! cellular response to water stimulus

[Term]
id: GO:0042632
name: cholesterol homeostasis
namespace: biological_process
alt_id: GO:2000188
alt_id: GO:2000189
def: "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
synonym: "positive regulation of cholesterol homeostasis" RELATED []
synonym: "regulation of cholesterol homeostasis" RELATED []
is_a: GO:0055092 ! sterol homeostasis

[Term]
id: GO:0042633
name: hair cycle
namespace: biological_process
def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0042634
name: regulation of hair cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042635
name: positive regulation of hair cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
synonym: "activation of hair cycle" NARROW []
synonym: "stimulation of hair cycle" NARROW []
synonym: "up regulation of hair cycle" EXACT []
synonym: "up-regulation of hair cycle" EXACT []
synonym: "upregulation of hair cycle" EXACT []
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042636
name: negative regulation of hair cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
synonym: "down regulation of hair cycle" EXACT []
synonym: "down-regulation of hair cycle" EXACT []
synonym: "downregulation of hair cycle" EXACT []
synonym: "inhibition of hair cycle" NARROW []
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042637
name: catagen
namespace: biological_process
def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair regression" NARROW []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042638
name: exogen
namespace: biological_process
def: "The shedding phase of the hair cycle." [PMID:12230507]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair shedding" NARROW []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042639
name: telogen
namespace: biological_process
def: "The resting phase of hair cycle." [PMID:12230507]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair resting phase" NARROW []
is_a: GO:0044851 ! hair cycle phase

[Term]
id: GO:0042640
name: anagen
namespace: biological_process
def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair growth" RELATED []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042641
name: actomyosin
namespace: cellular_component
def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
synonym: "actomyosin complex" EXACT []
synonym: "actomyosin structure" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0042642
name: actomyosin, myosin complex part
namespace: cellular_component
def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0016459 ! myosin complex
relationship: part_of GO:0042641 ! actomyosin

[Term]
id: GO:0042643
name: obsolete actomyosin, actin portion
namespace: cellular_component
def: "OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
comment: This term was obsoleted because it corresponds to a gene product, actin.
is_obsolete: true

[Term]
id: GO:0042644
name: chloroplast nucleoid
namespace: cellular_component
def: "The region of a chloroplast to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0042645
name: mitochondrial nucleoid
namespace: cellular_component
def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0042646
name: plastid nucleoid
namespace: cellular_component
def: "The region of a plastid to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0042647
name: proplastid nucleoid
namespace: cellular_component
def: "The region of a proplastid to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
relationship: part_of GO:0009571 ! proplastid stroma

[Term]
id: GO:0042648
name: chloroplast chromosome
namespace: cellular_component
def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl]
is_a: GO:0009508 ! plastid chromosome
relationship: part_of GO:0042644 ! chloroplast nucleoid

[Term]
id: GO:0042649
name: prothylakoid
namespace: cellular_component
def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175]
is_a: GO:0031976 ! plastid thylakoid
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0042650
name: prothylakoid membrane
namespace: cellular_component
def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175]
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0042649 ! prothylakoid

[Term]
id: GO:0042651
name: thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of any thylakoid." [GOC:jl, GOC:pr]
is_a: GO:0034357 ! photosynthetic membrane

[Term]
id: GO:0042652
name: obsolete mitochondrial respiratory chain complex I, peripheral segment
namespace: cellular_component
def: "OBSOLETE. The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]
comment: The reason for obsoletion is that this term represents a sub-complex, out-of-scope for GO.
synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment" BROAD []
synonym: "NADH-Q oxidoreductase complex, peripheral segment" BROAD []
is_obsolete: true
replaced_by: GO:0045271

[Term]
id: GO:0042653
name: obsolete mitochondrial respiratory chain complex I, membrane segment
namespace: cellular_component
def: "OBSOLETE. The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]
comment: The reason for obsoletion is that this term represents a sub-complex, out-of-scope for GO.
synonym: "NADH-Q oxidoreductase complex, membrane segment" BROAD []
is_obsolete: true
replaced_by: GO:0045271

[Term]
id: GO:0042654
name: ecdysis-triggering hormone receptor activity
namespace: molecular_function
def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma]
synonym: "ecdysis-triggering hormone binding" NARROW []
synonym: "ETH receptor" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0042655
name: obsolete activation of JNKKK activity
namespace: biological_process
def: "OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of JUN kinase kinase kinase activity" EXACT []
synonym: "positive regulation of JUNKKK activity" BROAD []
is_obsolete: true
consider: GO:0007254
consider: GO:0043539

[Term]
id: GO:0042656
name: JUN kinase kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf]
synonym: "JUNKKKK activity" EXACT []
is_a: GO:0008349 ! MAP kinase kinase kinase kinase activity

[Term]
id: GO:0042657
name: MHC class II protein binding, via lateral surface
namespace: molecular_function
def: "Binding to the lateral surface of major histocompatibility complex class II molecules." [GOC:jl]
synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT []
is_a: GO:0042289 ! MHC class II protein binding

[Term]
id: GO:0042658
name: MHC class II protein binding, via antigen binding groove
namespace: molecular_function
def: "Binding to the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl]
synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT []
is_a: GO:0042289 ! MHC class II protein binding
relationship: part_of GO:0023026 ! MHC class II protein complex binding

[Term]
id: GO:0042659
name: regulation of cell fate specification
namespace: biological_process
def: "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]
is_a: GO:0010453 ! regulation of cell fate commitment
relationship: regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0042660
name: positive regulation of cell fate specification
namespace: biological_process
def: "Any process that activates or enables a cell to adopt a specific fate." [GOC:go_curators]
synonym: "activation of cell fate specification" NARROW []
synonym: "stimulation of cell fate specification" NARROW []
synonym: "up regulation of cell fate specification" EXACT []
synonym: "up-regulation of cell fate specification" EXACT []
synonym: "upregulation of cell fate specification" EXACT []
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0042659 ! regulation of cell fate specification
relationship: positively_regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0042661
name: regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0042662
name: negative regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]
synonym: "down regulation of mesodermal cell fate specification" EXACT []
synonym: "down-regulation of mesodermal cell fate specification" EXACT []
synonym: "downregulation of mesodermal cell fate specification" EXACT []
synonym: "inhibition of mesodermal cell fate specification" NARROW []
synonym: "suppression of mesodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
is_a: GO:1905771 ! negative regulation of mesodermal cell differentiation
relationship: negatively_regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0042663
name: regulation of endodermal cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an endoderm cell." [GOC:go_curators]
synonym: "regulation of endoderm cell fate specification" EXACT []
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1903224 ! regulation of endodermal cell differentiation
relationship: regulates GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0042664
name: negative regulation of endodermal cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators]
synonym: "down regulation of endodermal cell fate specification" EXACT []
synonym: "down-regulation of endodermal cell fate specification" EXACT []
synonym: "downregulation of endodermal cell fate specification" EXACT []
synonym: "inhibition of endodermal cell fate specification" NARROW []
synonym: "negative regulation of endoderm cell fate specification" EXACT []
synonym: "suppression of endoderm cell fate" EXACT []
synonym: "suppression of endodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042663 ! regulation of endodermal cell fate specification
is_a: GO:1903225 ! negative regulation of endodermal cell differentiation
relationship: negatively_regulates GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0042665
name: regulation of ectodermal cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an ectoderm cell." [GOC:go_curators]
synonym: "regulation of ectoderm cell fate specification" EXACT []
is_a: GO:0042659 ! regulation of cell fate specification
relationship: regulates GO:0001715 ! ectodermal cell fate specification

[Term]
id: GO:0042666
name: negative regulation of ectodermal cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators]
synonym: "down regulation of ectodermal cell fate specification" EXACT []
synonym: "down-regulation of ectodermal cell fate specification" EXACT []
synonym: "downregulation of ectodermal cell fate specification" EXACT []
synonym: "inhibition of ectodermal cell fate specification" NARROW []
synonym: "negative regulation of ectoderm cell fate specification" EXACT []
synonym: "suppression of ectoderm cell fate" EXACT []
synonym: "suppression of ectodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042665 ! regulation of ectodermal cell fate specification
relationship: negatively_regulates GO:0001715 ! ectodermal cell fate specification

[Term]
id: GO:0042667
name: auditory receptor cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "auditory hair cell fate specification" EXACT []
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0009912 ! auditory receptor cell fate commitment

[Term]
id: GO:0042668
name: auditory receptor cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "auditory hair cell fate determination" EXACT []
is_a: GO:0048664 ! neuron fate determination
relationship: part_of GO:0009912 ! auditory receptor cell fate commitment

[Term]
id: GO:0042669
name: regulation of inner ear auditory receptor cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators]
synonym: "regulation of auditory hair cell fate specification" EXACT []
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation
relationship: regulates GO:0042667 ! auditory receptor cell fate specification

[Term]
id: GO:0042670
name: retinal cone cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0042671
name: retinal cone cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0043703 ! photoreceptor cell fate determination
relationship: part_of GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0042672
name: retinal cone cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
is_a: GO:0043704 ! photoreceptor cell fate specification
relationship: part_of GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0042673
name: regulation of retinal cone cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0060222 ! regulation of retinal cone cell fate commitment
relationship: regulates GO:0042672 ! retinal cone cell fate specification

[Term]
id: GO:0042675
name: compound eye cone cell differentiation
namespace: biological_process
alt_id: GO:0042674
def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0042676
name: compound eye cone cell fate commitment
namespace: biological_process
alt_id: GO:0007466
def: "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0042675 ! compound eye cone cell differentiation

[Term]
id: GO:0042679
name: compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0042678
def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0042676 ! compound eye cone cell fate commitment

[Term]
id: GO:0042680
name: compound eye cone cell fate determination
namespace: biological_process
alt_id: GO:0042677
def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0042676 ! compound eye cone cell fate commitment

[Term]
id: GO:0042682
name: regulation of compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0042681
def: "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu]
is_a: GO:0042659 ! regulation of cell fate specification
relationship: regulates GO:0042679 ! compound eye cone cell fate specification

[Term]
id: GO:0042683
name: negative regulation of compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0010000
def: "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu]
synonym: "down regulation of cone cell fate specification" BROAD []
synonym: "down-regulation of cone cell fate specification" BROAD []
synonym: "downregulation of cone cell fate specification" BROAD []
synonym: "inhibition of cone cell fate specification" BROAD []
synonym: "suppression of cone cell fate" BROAD []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042682 ! regulation of compound eye cone cell fate specification
relationship: negatively_regulates GO:0042679 ! compound eye cone cell fate specification

[Term]
id: GO:0042684
name: cardioblast cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0042685
name: cardioblast cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060912 ! cardiac cell fate specification
relationship: part_of GO:0042684 ! cardioblast cell fate commitment

[Term]
id: GO:0042686
name: regulation of cardioblast cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:2000043 ! regulation of cardiac cell fate specification
relationship: regulates GO:0042685 ! cardioblast cell fate specification

[Term]
id: GO:0042688
name: crystal cell differentiation
namespace: biological_process
def: "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0042689
name: regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042690
name: negative regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
synonym: "down regulation of crystal cell differentiation" EXACT []
synonym: "down-regulation of crystal cell differentiation" EXACT []
synonym: "downregulation of crystal cell differentiation" EXACT []
synonym: "inhibition of crystal cell differentiation" NARROW []
is_a: GO:0042689 ! regulation of crystal cell differentiation
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
relationship: negatively_regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042691
name: positive regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
synonym: "activation of crystal cell differentiation" NARROW []
synonym: "stimulation of crystal cell differentiation" NARROW []
synonym: "up regulation of crystal cell differentiation" EXACT []
synonym: "up-regulation of crystal cell differentiation" EXACT []
synonym: "upregulation of crystal cell differentiation" EXACT []
is_a: GO:0042689 ! regulation of crystal cell differentiation
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
relationship: positively_regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042692
name: muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]
synonym: "myogenesis" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0061061 ! muscle structure development

[Term]
id: GO:0042693
name: muscle cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0042694
name: muscle cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0042693 ! muscle cell fate commitment

[Term]
id: GO:0042695
name: thelarche
namespace: biological_process
def: "The beginning of development of the breasts in the female." [GOC:curators, PMID:19117864]
xref: Wikipedia:Thelarche
is_a: GO:0046543 ! development of secondary female sexual characteristics
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0042696
name: menarche
namespace: biological_process
def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [GOC:curators, PMID:16311040]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Menarche
is_a: GO:0022601 ! menstrual cycle phase

[Term]
id: GO:0042697
name: menopause
namespace: biological_process
def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [GOC:curators, PMID:18495681]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Menopause
is_a: GO:0022601 ! menstrual cycle phase
is_a: GO:1990636 ! reproductive senescence

[Term]
id: GO:0042698
name: ovulation cycle
namespace: biological_process
def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544]
is_a: GO:0048511 ! rhythmic process
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0042699
name: follicle-stimulating hormone signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:dph]
synonym: "follicle stimulating hormone signaling pathway" EXACT []
synonym: "follicle stimulating hormone signalling pathway" EXACT []
synonym: "follicle-stimulating hormone signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0042700
name: luteinizing hormone signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by luteinizing hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:dph]
synonym: "luteinizing hormone signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0042701
name: progesterone secretion
namespace: biological_process
def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0035929 ! steroid hormone secretion
relationship: part_of GO:0001553 ! luteinization

[Term]
id: GO:0042702
name: uterine wall growth
namespace: biological_process
def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001553 ! luteinization

[Term]
id: GO:0042703
name: menstruation
namespace: biological_process
def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [GOC:curators, PMID:8693059]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Menstruation
is_a: GO:0022601 ! menstrual cycle phase

[Term]
id: GO:0042704
name: uterine wall breakdown
namespace: biological_process
def: "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph]
is_a: GO:0022602 ! ovulation cycle process

[Term]
id: GO:0042705
name: ocellus photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0042706
name: eye photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0046552 ! photoreceptor cell fate commitment
relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation

[Term]
id: GO:0042707
name: ocellus photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0046552 ! photoreceptor cell fate commitment
relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation

[Term]
id: GO:0042708
name: obsolete elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of elastin." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "elastase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0042709
name: succinate-CoA ligase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [GOC:jl, PMID:10671455]
is_a: GO:0045239 ! tricarboxylic acid cycle heteromeric enzyme complex

[Term]
id: GO:0042710
name: biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
is_a: GO:0098630 ! aggregation of unicellular organisms

[Term]
id: GO:0042711
name: maternal behavior
namespace: biological_process
def: "Female behaviors associated with the care and rearing of offspring." [GOC:curators]
synonym: "maternal behaviour" EXACT []
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0042712
name: paternal behavior
namespace: biological_process
def: "Male behaviors associated with the care and rearing offspring." [GOC:go_curators]
synonym: "paternal behaviour" EXACT []
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0042713
name: sperm ejaculation
namespace: biological_process
def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, PMID:26385403]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0042714
name: dosage compensation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0007549 ! sex-chromosome dosage compensation

[Term]
id: GO:0042715
name: obsolete dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361, PMID:12672493]
comment: The reason for obsoletion is that this represents a GO-CAM model.
synonym: "dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0042716
name: plasma membrane-derived chromatophore
namespace: cellular_component
def: "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431]
comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin.
synonym: "chromatophore vesicle" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0042717
name: plasma membrane-derived chromatophore membrane
namespace: cellular_component
def: "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431]
is_a: GO:0034357 ! photosynthetic membrane
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0042718
name: yolk granule
namespace: cellular_component
def: "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, PMID:18046696, PMID:6337890]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060417 ! yolk

[Term]
id: GO:0042719
name: mitochondrial intermembrane space protein transporter complex
namespace: cellular_component
def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]
synonym: "Tim9-Tim10 complex" NARROW []
is_a: GO:0098798 ! mitochondrial protein-containing complex
is_a: GO:1990351 ! transporter complex
relationship: part_of GO:0005758 ! mitochondrial intermembrane space

[Term]
id: GO:0042720
name: mitochondrial inner membrane peptidase complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]
synonym: "IMP" NARROW []
synonym: "mitochondrion inner membrane peptidase complex" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
is_a: GO:1905370 ! serine-type endopeptidase complex

[Term]
id: GO:0042721
name: TIM22 mitochondrial import inner membrane insertion complex
namespace: cellular_component
def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12." [PMID:12191765, PMID:27554484]
synonym: "mitochondrial inner membrane protein insertion complex" EXACT []
synonym: "mitochondrial protein translocase complex" BROAD []
synonym: "Tim22 complex" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:0042722
name: alpha-beta T cell activation by superantigen
namespace: biological_process
def: "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl]
synonym: "alpha-beta T lymphocyte activation by superantigen" EXACT []
synonym: "alpha-beta T-cell activation by superantigen" EXACT []
synonym: "alpha-beta T-lymphocyte activation by superantigen" EXACT []
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0042723
name: thiamine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it." [GOC:jl]
synonym: "thiamin and derivative metabolic process" EXACT []
synonym: "thiamin and derivative metabolism" EXACT []
synonym: "thiamin-containing compound metabolic process" EXACT []
synonym: "thiamine and derivative metabolic process" EXACT []
synonym: "thiamine and derivative metabolism" EXACT []
synonym: "thiamine-containing compound metabolism" EXACT []
synonym: "vitamin B1 and derivative metabolic process" EXACT []
synonym: "vitamin B1 and derivative metabolism" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0042724
name: thiamine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds." [GOC:jl]
synonym: "thiamin and derivative biosynthesis" EXACT []
synonym: "thiamin and derivative biosynthetic process" EXACT []
synonym: "thiamin-containing compound biosynthetic process" EXACT []
synonym: "thiamine and derivative biosynthesis" EXACT []
synonym: "thiamine and derivative biosynthetic process" EXACT []
synonym: "thiamine-containing compound anabolism" EXACT []
synonym: "thiamine-containing compound biosynthesis" EXACT []
synonym: "thiamine-containing compound formation" EXACT []
synonym: "thiamine-containing compound synthesis" EXACT []
synonym: "vitamin B1 and derivative biosynthesis" EXACT []
synonym: "vitamin B1 and derivative biosynthetic process" EXACT []
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042723 ! thiamine-containing compound metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0042725
name: thiamine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it." [GOC:jl]
synonym: "thiamin and derivative catabolic process" EXACT []
synonym: "thiamin and derivative catabolism" EXACT []
synonym: "thiamin-containing compound catabolic process" EXACT []
synonym: "thiamine and derivative catabolic process" EXACT []
synonym: "thiamine and derivative catabolism" EXACT []
synonym: "thiamine-containing compound breakdown" EXACT []
synonym: "thiamine-containing compound catabolism" EXACT []
synonym: "thiamine-containing compound degradation" EXACT []
synonym: "vitamin B1 and derivative catabolic process" EXACT []
synonym: "vitamin B1 and derivative catabolism" EXACT []
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042723 ! thiamine-containing compound metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0042726
name: flavin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah]
synonym: "flavin-containing compound metabolism" EXACT []
synonym: "riboflavin and derivative metabolic process" RELATED []
synonym: "riboflavin and derivative metabolism" RELATED []
synonym: "vitamin B2 and derivative metabolic process" RELATED []
synonym: "vitamin B2 and derivative metabolism" RELATED []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042727
name: flavin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah]
synonym: "flavin-containing compound anabolism" EXACT []
synonym: "flavin-containing compound biosynthesis" EXACT []
synonym: "flavin-containing compound formation" EXACT []
synonym: "flavin-containing compound synthesis" EXACT []
synonym: "riboflavin and derivative biosynthesis" RELATED []
synonym: "riboflavin and derivative biosynthetic process" RELATED []
synonym: "vitamin B2 and derivative biosynthesis" RELATED []
synonym: "vitamin B2 and derivative biosynthetic process" RELATED []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042726 ! flavin-containing compound metabolic process

[Term]
id: GO:0042728
name: flavin-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah]
synonym: "flavin-containing compound catabolic process breakdown" EXACT []
synonym: "flavin-containing compound catabolic process degradation" EXACT []
synonym: "flavin-containing compound catabolism" EXACT []
synonym: "riboflavin and derivative catabolic process" RELATED []
synonym: "riboflavin and derivative catabolism" RELATED []
synonym: "vitamin B2 and derivative catabolic process" RELATED []
synonym: "vitamin B2 and derivative catabolism" RELATED []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process

[Term]
id: GO:0042729
name: DASH complex
namespace: cellular_component
alt_id: GO:0043925
alt_id: GO:0043926
def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, GOC:vw, PMID:11782438, PMID:11799062, PMID:15632076, PMID:15640796]
comment: Note that this complex is conserved in fungi but has not been observed in metazoans.
synonym: "condensed nuclear chromosome kinetochore-associated DASH complex" EXACT []
synonym: "Dam1 complex" EXACT []
synonym: "DDD complex" EXACT []
synonym: "Duo1p-Dam1p-Dad1p complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000940 ! outer kinetochore

[Term]
id: GO:0042730
name: fibrinolysis
namespace: biological_process
def: "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin." [GOC:jl, PMID:15842654]
xref: Wikipedia:Fibrinolysis
is_a: GO:0030195 ! negative regulation of blood coagulation

[Term]
id: GO:0042731
name: PH domain binding
namespace: molecular_function
def: "Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0042732
name: D-xylose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
synonym: "D-xylose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0042733
name: embryonic digit morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe." [GOC:bf, GOC:jl, UBERON:0002544]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0030326 ! embryonic limb morphogenesis

[Term]
id: GO:0042734
name: presynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]
subset: goslim_synapse
synonym: "pre-synaptic membrane" EXACT []
synonym: "presynaptic plasma membrane" EXACT []
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0042735
name: endosperm protein body
namespace: cellular_component
def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0042736
name: NADH kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NADH = ADP + 2 H+ + NADPH." [EC:2.7.1.86, RHEA:12260]
synonym: "ATP:NADH 2'-phosphotransferase activity" RELATED [EC:2.7.1.86]
synonym: "DPNH kinase activity" RELATED [EC:2.7.1.86]
synonym: "reduced diphosphopyridine nucleotide kinase activity" RELATED [EC:2.7.1.86]
synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" RELATED [EC:2.7.1.86]
xref: EC:2.7.1.86
xref: KEGG_REACTION:R00105
xref: MetaCyc:NADH-KINASE-RXN
xref: RHEA:12260
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0042739
name: obsolete endogenous drug catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl]
comment: The reason for obsoletion is that there is no evidence that this process exists as a drug is by definition exogenous.
synonym: "endogenous drug breakdown" EXACT []
synonym: "endogenous drug catabolism" EXACT []
synonym: "endogenous drug degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0042740
name: exogenous antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl]
synonym: "exogenous antibiotic breakdown" EXACT []
synonym: "exogenous antibiotic catabolism" EXACT []
synonym: "exogenous antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
relationship: part_of GO:0046677 ! response to antibiotic

[Term]
id: GO:0042741
name: endogenous antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl]
synonym: "endogenous antibiotic breakdown" EXACT []
synonym: "endogenous antibiotic catabolism" EXACT []
synonym: "endogenous antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process

[Term]
id: GO:0042742
name: defense response to bacterium
namespace: biological_process
alt_id: GO:0009816
alt_id: GO:0042830
def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
synonym: "antibacterial peptide activity" RELATED []
synonym: "defence response to bacteria" EXACT []
synonym: "defence response to bacterium" EXACT []
synonym: "defense response to bacteria" EXACT []
synonym: "defense response to bacterium, incompatible interaction" NARROW []
synonym: "resistance response to pathogenic bacteria" NARROW []
synonym: "resistance response to pathogenic bacterium" NARROW []
is_a: GO:0009617 ! response to bacterium
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0042743
name: hydrogen peroxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, PMID:21734470]
synonym: "H2O2 metabolic process" EXACT [GOC:mah]
synonym: "hydrogen peroxide metabolism" EXACT []
is_a: GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:0042744
name: hydrogen peroxide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
synonym: "detoxification of H2O2" RELATED [GOC:vw]
synonym: "detoxification of hydrogen peroxide" RELATED [GOC:vw]
synonym: "H2O2 catabolic process" EXACT [GOC:mah]
synonym: "H2O2 scavenging" RELATED [GOC:vw]
synonym: "hydrogen peroxide breakdown" EXACT []
synonym: "hydrogen peroxide catabolism" EXACT []
synonym: "hydrogen peroxide degradation" EXACT []
synonym: "hydrogen peroxide removal" RELATED []
synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw]
is_a: GO:0009056 ! catabolic process
is_a: GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0042745
name: circadian sleep/wake cycle
namespace: biological_process
def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, PMID:26947521, PMID:33537937]
is_a: GO:0048512 ! circadian behavior

[Term]
id: GO:0042746
name: circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468]
is_a: GO:0022410 ! circadian sleep/wake cycle process

[Term]
id: GO:0042747
name: circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172]
is_a: GO:0022410 ! circadian sleep/wake cycle process
relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042748
name: circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, PMID:33537937]
is_a: GO:0022410 ! circadian sleep/wake cycle process
relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042749
name: regulation of circadian sleep/wake cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl]
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0042745 ! circadian sleep/wake cycle

[Term]
id: GO:0042750
name: hibernation
namespace: biological_process
def: "Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, PMID:1945046]
xref: Wikipedia:Hibernation
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0042751
name: estivation
namespace: biological_process
def: "Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, PMID:12443930, Wikipedia:Estivation]
synonym: "aestivation" EXACT [GOC:pr]
xref: Wikipedia:Estivation
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0042752
name: regulation of circadian rhythm
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042753
name: positive regulation of circadian rhythm
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]
synonym: "activation of circadian rhythm" NARROW []
synonym: "stimulation of circadian rhythm" NARROW []
synonym: "up regulation of circadian rhythm" EXACT []
synonym: "up-regulation of circadian rhythm" EXACT []
synonym: "upregulation of circadian rhythm" EXACT []
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042754
name: negative regulation of circadian rhythm
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]
synonym: "down regulation of circadian rhythm" EXACT []
synonym: "down-regulation of circadian rhythm" EXACT []
synonym: "downregulation of circadian rhythm" EXACT []
synonym: "inhibition of circadian rhythm" NARROW []
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042755
name: eating behavior
namespace: biological_process
def: "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, GOC:pr, PMID:19361967]
synonym: "eating behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior

[Term]
id: GO:0042756
name: drinking behavior
namespace: biological_process
def: "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr]
synonym: "drinking behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior

[Term]
id: GO:0042757
name: giant axon
namespace: cellular_component
def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, PMID:9705477]
is_a: GO:0030424 ! axon

[Term]
id: GO:0042758
name: long-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [PMID:20043225]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acid breakdown" EXACT []
synonym: "long-chain fatty acid catabolism" EXACT []
synonym: "long-chain fatty acid degradation" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0009062 ! fatty acid catabolic process

[Term]
id: GO:0042759
name: long-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [PMID:18390550]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acid anabolism" EXACT []
synonym: "long-chain fatty acid biosynthesis" EXACT []
synonym: "long-chain fatty acid formation" EXACT []
synonym: "long-chain fatty acid synthesis" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042760
name: very long-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very-long-chain fatty acid breakdown" EXACT []
synonym: "very-long-chain fatty acid catabolic process" EXACT []
synonym: "very-long-chain fatty acid catabolism" EXACT []
synonym: "very-long-chain fatty acid degradation" EXACT []
is_a: GO:0000038 ! very long-chain fatty acid metabolic process
is_a: GO:0009062 ! fatty acid catabolic process

[Term]
id: GO:0042761
name: very long-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very-long-chain fatty acid anabolism" EXACT []
synonym: "very-long-chain fatty acid biosynthesis" EXACT []
synonym: "very-long-chain fatty acid biosynthetic process" EXACT []
synonym: "very-long-chain fatty acid formation" EXACT []
synonym: "very-long-chain fatty acid synthesis" EXACT []
xref: MetaCyc:PWY-5080
is_a: GO:0000038 ! very long-chain fatty acid metabolic process
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042762
name: regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators]
synonym: "regulation of sulfur metabolism" EXACT []
synonym: "regulation of sulphur metabolic process" EXACT []
synonym: "regulation of sulphur metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0042763
name: intracellular immature spore
namespace: cellular_component
def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172]
synonym: "forespore" RELATED []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0042764
name: ascospore-type prospore
namespace: cellular_component
def: "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi." [GOC:go_curators]
is_a: GO:0042763 ! intracellular immature spore

[Term]
id: GO:0042765
name: GPI-anchor transamidase complex
namespace: cellular_component
def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity.
synonym: "GPIT complex" EXACT []
is_a: GO:0008303 ! caspase complex
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0042766
name: obsolete nucleosome mobilization
namespace: biological_process
def: "OBSOLETE. The movement of nucleosomes along a DNA fragment." [PMID:12006495]
comment: This term was obsoleted because it represents a molecular function.
synonym: "nucleosome sliding" EXACT [GOC:dph]
is_obsolete: true
consider: GO:0140658
consider: GO:0140750
consider: GO:0140751

[Term]
id: GO:0042767
name: ecdysteroid 22-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone.
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0042768
name: ecdysteroid 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxyecdysone + 2 reduced adrenodoxin + O2 + 2 H+ = ecdysone + 2 oxidized adrenodoxin + H2O." [MetaCyc:RXN-14679, PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone.
xref: MetaCyc:RXN-14679
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0042769
name: obsolete DNA damage response, detection of DNA damage
namespace: biological_process
def: "OBSOLETE. The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators]
comment: This term has been obsoleted because it represents a molecular function.
synonym: "detection of DNA damage during DNA damage response" EXACT []
synonym: "DNA damage response, perception of DNA damage" RELATED []
is_obsolete: true
consider: GO:0006281
consider: GO:0140612
consider: GO:0140664

[Term]
id: GO:0042770
name: signal transduction in response to DNA damage
namespace: biological_process
alt_id: GO:0006975
def: "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators]
synonym: "DNA damage induced protein phosphorylation" NARROW []
synonym: "DNA damage response, signal transduction" EXACT []
synonym: "response to DNA damage stimulus by intracellular signaling cascade" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006974 ! DNA damage response
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0042771
name: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED []
is_a: GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator

[Term]
id: GO:0042772
name: DNA damage response, signal transduction resulting in transcription
namespace: biological_process
def: "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators]
is_a: GO:0042770 ! signal transduction in response to DNA damage

[Term]
id: GO:0042773
name: ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0042774
name: plasma membrane ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane." [GOC:mtg_sensu, ISBN:0716731363]
is_a: GO:0042773 ! ATP synthesis coupled electron transport

[Term]
id: GO:0042775
name: mitochondrial ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]
synonym: "mitochondrial electron transport" BROAD []
synonym: "organelle ATP synthesis coupled electron transport" BROAD []
is_a: GO:0042773 ! ATP synthesis coupled electron transport

[Term]
id: GO:0042776
name: proton motive force-driven mitochondrial ATP synthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw]
synonym: "mitochondrial ATP synthesis coupled proton transport" RELATED []
synonym: "mitochondrial proton transport" RELATED []
is_a: GO:0015986 ! proton motive force-driven ATP synthesis
relationship: part_of GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0042777
name: proton motive force-driven plasma membrane ATP synthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a plasma membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw]
synonym: "ATP synthesis coupled proton transport" RELATED []
synonym: "plasma membrane ATP synthesis coupled proton transport" RELATED []
is_a: GO:0015986 ! proton motive force-driven ATP synthesis

[Term]
id: GO:0042778
name: tRNA end turnover
namespace: biological_process
def: "The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators]
is_a: GO:0006399 ! tRNA metabolic process

[Term]
id: GO:0042779
name: obsolete tRNA 3'-trailer cleavage
namespace: biological_process
def: "OBSOLETE. Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators]
comment: The reason for obsoletion is that the term represents a molecular function.
synonym: "removal of tRNA 3'-trailer sequence" EXACT []
synonym: "tRNA 3'-end cleavage" EXACT []
is_obsolete: true
replaced_by: GO:0042780

[Term]
id: GO:0042780
name: tRNA 3'-end processing
namespace: biological_process
def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators]
synonym: "tRNA 3' processing" EXACT []
is_a: GO:0008033 ! tRNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0042781
name: 3'-tRNA processing endoribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [PMID:12032089, PMID:21208191]
synonym: "3 tRNase activity" RELATED [EC:3.1.26.11]
synonym: "3' tRNA processing endoribonuclease activity" EXACT []
synonym: "3' tRNase activity" EXACT []
synonym: "ribonuclease Z activity" BROAD []
synonym: "RNase Z activity" BROAD []
synonym: "tRNA 3 endonuclease activity" RELATED [EC:3.1.26.11]
synonym: "tRNA 3' endonuclease activity" EXACT []
synonym: "tRNAse Z" RELATED [EC:3.1.26.11]
xref: EC:3.1.26.11
xref: MetaCyc:3.1.26.11-RXN
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0042783
name: symbiont-mediated evasion of host immune response
namespace: biological_process
alt_id: GO:0020012
alt_id: GO:0042782
alt_id: GO:0051805
alt_id: GO:0051809
alt_id: GO:0051810
def: "A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb, PMID:12439615]
synonym: "active evasion of host immune response" RELATED []
synonym: "active evasion of immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "active immune evasion" BROAD []
synonym: "evasion by virus of host immune response" RELATED []
synonym: "evasion of host immune response" EXACT []
synonym: "evasion or tolerance of host immune response" BROAD []
synonym: "immune evasion" EXACT []
synonym: "mitigation by virus of host immune response" RELATED []
synonym: "mitigation of host immune response" RELATED []
synonym: "mitigation of host immune response by virus" RELATED []
synonym: "passive evasion of host immune response" RELATED []
synonym: "passive evasion of immune response of other organism involved in symbiotic interaction" RELATED []
synonym: "passive immune evasion" RELATED []
synonym: "suppression by virus of host immune response" RELATED []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0042784
name: symbiont-mediated suppression of host complement activation
namespace: biological_process
alt_id: GO:0051811
def: "A process by which a symbiont inhibits or disrupts the normal execution of the activation of complement in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20194595, PMID:21191012, PMID:25830295, PMID:7745740]
synonym: "active evasion of host immune response via regulation of host complement system" RELATED []
synonym: "active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction" BROAD []
synonym: "active immune evasion via modulation of host complement system" EXACT []
synonym: "active immune evasion via regulation of host complement system" EXACT []
synonym: "evasion of host immune response via modulation of host complement system" EXACT []
synonym: "evasion of host immune response via regulation of host complement system" EXACT []
synonym: "suppression of complement activation by another organism" BROAD []
xref: VZ:811
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response

[Term]
id: GO:0042785
name: obsolete evasion of host immune response via modulation of host cytokine network
namespace: biological_process
alt_id: GO:0051812
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:10620615, PMID:9275219, PMID:9600978]
comment: This term was obsoleted because it was poorly defined and used inconsistently.
synonym: "active evasion of host immune response via regulation of host cytokine network" RELATED []
synonym: "active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction" BROAD []
synonym: "active immune evasion via modulation of host cytokine network" EXACT []
synonym: "active immune evasion via regulation of host cytokine network" EXACT []
synonym: "evasion of host immune response via regulation of host cytokine network" EXACT []
is_obsolete: true

[Term]
id: GO:0042786
name: obsolete evasion of host immune response via modulation of host antigen processing and presentation
namespace: biological_process
alt_id: GO:0051813
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host antigen processing and presentation ; GO:0039588.
synonym: "active evasion of host immune response via regulation of host antigen processing and presentation" RELATED []
synonym: "active evasion of host immune response via regulation of host antigen processing and presentation pathway" EXACT []
synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction" BROAD []
synonym: "active immune evasion via modulation of antigen processing and presentation" EXACT []
synonym: "active immune evasion via modulation of antigen processing/presentation" EXACT []
synonym: "active immune evasion via regulation of antigen processing and presentation" EXACT []
synonym: "evasion of host immune response via regulation of host antigen processing and presentation" EXACT []
is_obsolete: true
replaced_by: GO:0039588

[Term]
id: GO:0042788
name: obsolete polysomal ribosome
namespace: cellular_component
def: "OBSOLETE. A ribosome bound to mRNA that forms part of a polysome." [GOC:jl]
comment: The reason for obsoletion is that the term is out of scope for GO.
synonym: "active ribosome" BROAD []
is_obsolete: true
consider: GO:0005840

[Term]
id: GO:0042789
name: mRNA transcription by RNA polymerase II
namespace: biological_process
def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:jl, ISBN:0321000382]
synonym: "mRNA transcription from Pol II promoter" EXACT []
synonym: "mRNA transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006366 ! transcription by RNA polymerase II
is_a: GO:0009299 ! mRNA transcription

[Term]
id: GO:0042790
name: nucleolar large rRNA transcription by RNA polymerase I
namespace: biological_process
def: "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I." [GOC:jl, GOC:txnOH, ISBN:0321000382]
synonym: "transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT []
synonym: "transcription of nuclear rRNA large Pol I transcript" EXACT []
synonym: "transcription of nucleolar large rRNA by RNA polymerase I" EXACT []
is_a: GO:0006360 ! transcription by RNA polymerase I
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042791
name: 5S class rRNA transcription by RNA polymerase III
namespace: biological_process
def: "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter." [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659]
synonym: "5S class rRNA transcription from RNA polymerase III type 1 promoter" RELATED []
synonym: "5S rRNA transcription" EXACT []
is_a: GO:0006383 ! transcription by RNA polymerase III
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042792
name: obsolete mitochondrial rRNA transcription
namespace: biological_process
def: "OBSOLETE. The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, PMID:23632312]
comment: This term was obsoleted because it is the same as its parent, 'mitochondrial transcription', since there is no specific pathway or factors for rRNA transcription.
synonym: "rRNA transcription from mitochondrial promoter" EXACT []
is_obsolete: true
replaced_by: GO:0006390

[Term]
id: GO:0042793
name: plastid transcription
namespace: biological_process
def: "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]
synonym: "transcription from plastid promoter" EXACT []
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0042794
name: plastid rRNA transcription
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]
synonym: "rRNA transcription from plastid promoter" EXACT []
is_a: GO:0009303 ! rRNA transcription
is_a: GO:0042793 ! plastid transcription

[Term]
id: GO:0042795
name: snRNA transcription by RNA polymerase II
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]
synonym: "snRNA transcription from Pol II promoter" EXACT []
synonym: "snRNA transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006366 ! transcription by RNA polymerase II
is_a: GO:0009301 ! snRNA transcription

[Term]
id: GO:0042796
name: snRNA transcription by RNA polymerase III
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]
synonym: "snRNA transcription from Pol III promoter" EXACT []
synonym: "snRNA transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0006383 ! transcription by RNA polymerase III
is_a: GO:0009301 ! snRNA transcription

[Term]
id: GO:0042797
name: tRNA transcription by RNA polymerase III
namespace: biological_process
def: "The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]
synonym: "tRNA transcription from Pol III promoter" EXACT []
synonym: "tRNA transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0006383 ! transcription by RNA polymerase III
is_a: GO:0009304 ! tRNA transcription

[Term]
id: GO:0042798
name: obsolete protein neddylation during NEDD8 class-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl]
comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction.
synonym: "protein neddylation during NEDD8 class-dependent protein breakdown" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein catabolic process" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein catabolism" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein degradation" EXACT []
synonym: "protein neddylation during RUB1-dependent protein catabolic process" EXACT []
synonym: "protein neddylation during RUB1-dependent protein catabolism" EXACT []
is_obsolete: true
consider: GO:0045116

[Term]
id: GO:0042799
name: histone H4K20 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]
comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies.
synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT []
synonym: "histone H4K20 methylase activity" BROAD []
synonym: "histone H4K20 methylation" EXACT []
synonym: "histone lysine N-methyltransferase activity (H4-K20 specific)" EXACT []
synonym: "histone methylase activity (H4-K20 specific)" EXACT []
synonym: "histone methyltransferase activity (H4-K20 specific)" EXACT []
synonym: "histone-H4K20 methyltransferase activity" EXACT []
xref: Reactome:R-HSA-2301205 "SETD8 monomethylates histone H4"
xref: Reactome:R-HSA-5682965 "WHSC1 dimethylates histone H4 on lysine K21 at DSBs"
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140939 ! histone H4 methyltransferase activity

[Term]
id: GO:0042800
name: histone H3K4 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein." [PMID:12086618]
comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies.
synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT []
synonym: "histone H3K4 methylase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT []
synonym: "histone methylase activity (H3-K4 specific)" EXACT [GOC:mah]
synonym: "histone methyltransferase activity (H3-K4 specific)" EXACT []
synonym: "histone-H3K4 methyltransferase activity" EXACT []
xref: Reactome:R-HSA-1214188 "PRDM9 trimethylates histone H3"
xref: Reactome:R-HSA-3364026 "SET1 complex trimethylates H3K4 at the MYC gene"
xref: Reactome:R-HSA-8865498 "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark"
xref: Reactome:R-HSA-8936481 "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter"
xref: Reactome:R-HSA-8936621 "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter"
xref: Reactome:R-HSA-8937016 "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter"
xref: Reactome:R-HSA-8937050 "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter"
xref: Reactome:R-HSA-9843121 "KMT2D,(KMT2C) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers"
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0042801
name: obsolete polo kinase kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma]
comment: This term was made obsolete because it represents a gene product and also refers to a non-existent activity (polo kinase).
is_obsolete: true

[Term]
id: GO:0042802
name: identical protein binding
namespace: molecular_function
def: "Binding to an identical protein or proteins." [GOC:jl]
subset: goslim_chembl
synonym: "isoform-specific homophilic binding" EXACT [PMID:17889655]
synonym: "protein homopolymerization" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042803
name: protein homodimerization activity
namespace: molecular_function
def: "Binding to an identical protein to form a homodimer." [GOC:jl]
subset: goslim_chembl
synonym: "dimerization activity" BROAD []
is_a: GO:0042802 ! identical protein binding
is_a: GO:0046983 ! protein dimerization activity

[Term]
id: GO:0042804
name: obsolete protein homooligomerization activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer." [GOC:jl]
comment: This term was made obsolete because it represents a biological process.
synonym: "oligomerization activity" BROAD []
synonym: "protein homooligomerization activity" EXACT []
is_obsolete: true
replaced_by: GO:0051260

[Term]
id: GO:0042805
name: actinin binding
namespace: molecular_function
alt_id: GO:0051406
def: "Binding to actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732]
synonym: "beta-actinin binding" NARROW []
synonym: "capZ binding" EXACT []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0042806
name: fucose binding
namespace: molecular_function
def: "Binding to fucose, the pentose 6-deoxygalactose." [ISBN:0582227089]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0042807
name: central vacuole
namespace: cellular_component
def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [ISBN:9780815341116, Wikipedia:Vacuole]
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0042808
name: obsolete neuronal Cdc2-like kinase binding
namespace: molecular_function
def: "OBSOLETE. Binding to neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "neuronal Cdc2-like kinase binding" EXACT []
is_obsolete: true
replaced_by: GO:0019901

[Term]
id: GO:0042809
name: nuclear vitamin D receptor binding
namespace: molecular_function
def: "Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, PMID:12637589]
synonym: "calciferol receptor binding" NARROW []
synonym: "VDR binding" EXACT []
synonym: "vitamin D receptor binding" BROAD []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0042810
name: pheromone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
subset: goslim_pir
synonym: "pheromone metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042811
name: pheromone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
synonym: "pheromone anabolism" EXACT []
synonym: "pheromone biosynthesis" EXACT []
synonym: "pheromone formation" EXACT []
synonym: "pheromone synthesis" EXACT []
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0042810 ! pheromone metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0042812
name: pheromone catabolic process
namespace: biological_process
alt_id: GO:0007327
alt_id: GO:0046614
def: "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
synonym: "pheromone breakdown" EXACT []
synonym: "pheromone catabolism" EXACT []
synonym: "pheromone degradation" EXACT []
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0042810 ! pheromone metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042813
name: Wnt receptor activity
namespace: molecular_function
def: "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]
subset: goslim_chembl
synonym: "frizzled receptor activity" RELATED []
synonym: "frizzled-2 receptor activity" RELATED []
synonym: "Wnt-activated receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0042814
name: monopolar cell growth
namespace: biological_process
def: "Polarized growth from one end of a cell." [GOC:vw]
synonym: "monopolar cell elongation" NARROW []
synonym: "monopolar growth" BROAD []
synonym: "polar cell elongation" NARROW []
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0042815
name: bipolar cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell." [GOC:vw]
comment: Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term 'establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246' and its children.
synonym: "bipolar cell elongation" NARROW []
synonym: "bipolar growth" BROAD []
synonym: "polar cell elongation" RELATED []
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0042816
name: vitamin B6 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, PMID:30037155, PMID:30671974]
synonym: "vitamin B6 metabolism" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0042817
name: pyridoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, PMID:21767669]
synonym: "pyridoxal metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042818
name: pyridoxamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl]
synonym: "pyridoxamine metabolism" EXACT []
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042819
name: vitamin B6 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, PMID:16157873, PMID:30671974]
synonym: "pyridoxine-5'-phosphate biosynthesis" RELATED [GOC:yaf, PMID:12271461]
synonym: "vitamin B6 anabolism" EXACT []
synonym: "vitamin B6 biosynthesis" EXACT []
synonym: "vitamin B6 formation" EXACT []
synonym: "vitamin B6 synthesis" EXACT []
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0042820
name: vitamin B6 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, PMID:30037155, PMID:30671974]
synonym: "vitamin B6 breakdown" EXACT []
synonym: "vitamin B6 catabolism" EXACT []
synonym: "vitamin B6 degradation" EXACT []
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0042821
name: pyridoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, PMID:21767669]
synonym: "pyridoxal anabolism" EXACT []
synonym: "pyridoxal biosynthesis" EXACT []
synonym: "pyridoxal formation" EXACT []
synonym: "pyridoxal synthesis" EXACT []
is_a: GO:0042817 ! pyridoxal metabolic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0042822
name: pyridoxal phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]
synonym: "active vitamin B6 metabolic process" EXACT []
synonym: "active vitamin B6 metabolism" EXACT []
synonym: "pyridoxal phosphate metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042823
name: pyridoxal phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]
synonym: "active vitamin B6 biosynthesis" EXACT []
synonym: "active vitamin B6 biosynthetic process" EXACT []
synonym: "pyridoxal phosphate anabolism" EXACT []
synonym: "pyridoxal phosphate biosynthesis" EXACT []
synonym: "pyridoxal phosphate formation" EXACT []
synonym: "pyridoxal phosphate synthesis" EXACT []
xref: MetaCyc:PWY0-845
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0042824
name: MHC class I peptide loading complex
namespace: cellular_component
def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934]
comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
subset: goslim_pir
synonym: "peptide-loading complex" EXACT [GOC:bhm]
synonym: "PLC" RELATED [GOC:bhm]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0042825
name: TAP complex
namespace: cellular_component
def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934]
synonym: "transporter associated with antigen presentation" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0042824 ! MHC class I peptide loading complex

[Term]
id: GO:0042826
name: histone deacetylase binding
namespace: molecular_function
def: "Binding to histone deacetylase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0042827
name: platelet dense granule
namespace: cellular_component
def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, PMID:10403682, PMID:11487378]
synonym: "bull's eye body" EXACT []
synonym: "platelet dense body" EXACT []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042832
name: defense response to protozoan
namespace: biological_process
alt_id: GO:0009818
def: "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl]
synonym: "defence response to pathogenic protozoa" EXACT []
synonym: "defence response to protozoa" EXACT []
synonym: "defence response to protozoon" EXACT []
synonym: "defense response to pathogenic protozoa" EXACT []
synonym: "defense response to protozoa" EXACT []
synonym: "defense response to protozoan, incompatible interaction" NARROW []
synonym: "defense response to protozoon" EXACT []
synonym: "resistance response to pathogenic protozoa" NARROW []
synonym: "resistance response to pathogenic protozoan" NARROW []
is_a: GO:0001562 ! response to protozoan
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0042834
name: peptidoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
is_a: GO:0005539 ! glycosaminoglycan binding

[Term]
id: GO:0042835
name: BRE binding
namespace: molecular_function
def: "Binding to a BRE RNA element (Bruno response element)." [PMID:10893231]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0042836
name: D-glucarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "D-glucarate metabolism" EXACT []
synonym: "saccharate metabolic process" EXACT []
synonym: "saccharate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0019392 ! glucarate metabolic process

[Term]
id: GO:0042837
name: D-glucarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "D-glucarate anabolism" EXACT []
synonym: "D-glucarate biosynthesis" EXACT []
synonym: "D-glucarate formation" EXACT []
synonym: "D-glucarate synthesis" EXACT []
synonym: "saccharate biosynthesis" EXACT []
synonym: "saccharate biosynthetic process" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0019393 ! glucarate biosynthetic process
is_a: GO:0042836 ! D-glucarate metabolic process

[Term]
id: GO:0042838
name: D-glucarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "D-glucarate breakdown" EXACT []
synonym: "D-glucarate catabolism" EXACT []
synonym: "D-glucarate degradation" EXACT []
synonym: "saccharate catabolic process" EXACT []
synonym: "saccharate catabolism" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019394 ! glucarate catabolic process
is_a: GO:0042836 ! D-glucarate metabolic process

[Term]
id: GO:0042839
name: D-glucuronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "D-glucuronate metabolism" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process

[Term]
id: GO:0042840
name: D-glucuronate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "D-glucuronate breakdown" EXACT []
synonym: "D-glucuronate catabolism" EXACT []
synonym: "D-glucuronate degradation" EXACT []
is_a: GO:0006064 ! glucuronate catabolic process
is_a: GO:0042839 ! D-glucuronate metabolic process

[Term]
id: GO:0042841
name: D-glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "D-glucuronate anabolism" EXACT []
synonym: "D-glucuronate biosynthesis" EXACT []
synonym: "D-glucuronate formation" EXACT []
synonym: "D-glucuronate synthesis" EXACT []
is_a: GO:0042839 ! D-glucuronate metabolic process
is_a: GO:0046399 ! glucuronate biosynthetic process

[Term]
id: GO:0042842
name: D-xylose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
synonym: "D-xylose anabolism" EXACT []
synonym: "D-xylose biosynthesis" EXACT []
synonym: "D-xylose formation" EXACT []
synonym: "D-xylose synthesis" EXACT []
is_a: GO:0019322 ! pentose biosynthetic process
is_a: GO:0042732 ! D-xylose metabolic process

[Term]
id: GO:0042843
name: D-xylose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
synonym: "D-xylose breakdown" EXACT []
synonym: "D-xylose catabolism" EXACT []
synonym: "D-xylose degradation" EXACT []
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0042732 ! D-xylose metabolic process

[Term]
id: GO:0042844
name: glycol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [PMID:9851711]
synonym: "dihydric alcohol metabolic process" BROAD []
synonym: "dihydric alcohol metabolism" BROAD []
synonym: "glycol metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0042845
name: glycol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [GOC:curators]
synonym: "dihydric alcohol biosynthesis" BROAD []
synonym: "dihydric alcohol biosynthetic process" BROAD []
synonym: "glycol anabolism" EXACT []
synonym: "glycol biosynthesis" EXACT []
synonym: "glycol formation" EXACT []
synonym: "glycol synthesis" EXACT []
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0042846
name: glycol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [Wikipedia:Ethylene_glycol]
synonym: "dihydric alcohol catabolic process" BROAD []
synonym: "dihydric alcohol catabolism" BROAD []
synonym: "glycol breakdown" EXACT []
synonym: "glycol catabolism" EXACT []
synonym: "glycol degradation" EXACT []
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0042847
name: sorbose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]
synonym: "sorbose anabolism" EXACT []
synonym: "sorbose biosynthesis" EXACT []
synonym: "sorbose formation" EXACT []
synonym: "sorbose synthesis" EXACT []
is_a: GO:0019311 ! sorbose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0042848
name: sorbose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]
synonym: "sorbose breakdown" EXACT []
synonym: "sorbose catabolism" EXACT []
synonym: "sorbose degradation" EXACT []
is_a: GO:0019311 ! sorbose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0042849
name: L-sorbose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [ISBN:0198506732]
synonym: "L-sorbose anabolism" EXACT []
synonym: "L-sorbose biosynthesis" EXACT []
synonym: "L-sorbose formation" EXACT []
synonym: "L-sorbose synthesis" EXACT []
is_a: GO:0019312 ! L-sorbose metabolic process
is_a: GO:0042847 ! sorbose biosynthetic process

[Term]
id: GO:0042850
name: L-sorbose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "L-sorbose breakdown" EXACT []
synonym: "L-sorbose catabolism" EXACT []
synonym: "L-sorbose degradation" EXACT []
is_a: GO:0019312 ! L-sorbose metabolic process
is_a: GO:0042848 ! sorbose catabolic process

[Term]
id: GO:0042851
name: L-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "L-alanine metabolism" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0009078 ! pyruvate family amino acid metabolic process

[Term]
id: GO:0042852
name: L-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "L-alanine anabolism" EXACT []
synonym: "L-alanine biosynthesis" EXACT []
synonym: "L-alanine formation" EXACT []
synonym: "L-alanine synthesis" EXACT []
is_a: GO:0006523 ! alanine biosynthetic process
is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0042853
name: L-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "L-alanine breakdown" EXACT []
synonym: "L-alanine catabolism" EXACT []
synonym: "L-alanine degradation" EXACT []
is_a: GO:0006524 ! alanine catabolic process
is_a: GO:0009080 ! pyruvate family amino acid catabolic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0042854
name: eugenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl]
synonym: "4-allyl-2-methoxyphenol metabolic process" EXACT []
synonym: "4-allyl-2-methoxyphenol metabolism" EXACT []
synonym: "eugenic acid metabolic process" EXACT []
synonym: "eugenic acid metabolism" EXACT []
synonym: "eugenol metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0042855
name: eugenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl]
synonym: "4-allyl-2-methoxyphenol biosynthesis" EXACT []
synonym: "4-allyl-2-methoxyphenol biosynthetic process" EXACT []
synonym: "eugenic acid biosynthesis" EXACT []
synonym: "eugenic acid biosynthetic process" EXACT []
synonym: "eugenol anabolism" EXACT []
synonym: "eugenol biosynthesis" EXACT []
synonym: "eugenol formation" EXACT []
synonym: "eugenol synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0042854 ! eugenol metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0042856
name: eugenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl]
synonym: "4-allyl-2-methoxyphenol catabolic process" EXACT []
synonym: "4-allyl-2-methoxyphenol catabolism" EXACT []
synonym: "eugenic acid catabolic process" EXACT []
synonym: "eugenic acid catabolism" EXACT []
synonym: "eugenol breakdown" EXACT []
synonym: "eugenol catabolism" EXACT []
synonym: "eugenol degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042854 ! eugenol metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0042857
name: chrysobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
synonym: "chrysobactin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0042858
name: chrysobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031183
alt_id: GO:0031184
def: "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
synonym: "chrysobactin anabolism" EXACT []
synonym: "chrysobactin biosynthesis" EXACT []
synonym: "chrysobactin biosynthetic process, peptide formation" NARROW []
synonym: "chrysobactin biosynthetic process, peptide modification" NARROW []
synonym: "chrysobactin formation" EXACT []
synonym: "chrysobactin synthesis" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042857 ! chrysobactin metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0042859
name: chrysobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
synonym: "chrysobactin breakdown" EXACT []
synonym: "chrysobactin catabolism" EXACT []
synonym: "chrysobactin degradation" EXACT []
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0042857 ! chrysobactin metabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0042860
name: achromobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
synonym: "achromobactin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042861
name: achromobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031181
alt_id: GO:0031182
def: "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
synonym: "achromobactin anabolism" EXACT []
synonym: "achromobactin biosynthesis" EXACT []
synonym: "achromobactin formation" EXACT []
synonym: "achromobactin synthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0042860 ! achromobactin metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0042862
name: achromobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
synonym: "achromobactin breakdown" EXACT []
synonym: "achromobactin catabolism" EXACT []
synonym: "achromobactin degradation" EXACT []
is_a: GO:0042860 ! achromobactin metabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0042863
name: pyochelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
synonym: "pyochelin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0042864
name: pyochelin biosynthetic process
namespace: biological_process
alt_id: GO:0031187
alt_id: GO:0031188
def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
synonym: "pyochelin anabolism" EXACT []
synonym: "pyochelin biosynthesis" EXACT []
synonym: "pyochelin biosynthetic process, peptide formation" NARROW []
synonym: "pyochelin biosynthetic process, peptide modification" NARROW []
synonym: "pyochelin formation" EXACT []
synonym: "pyochelin synthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0042863 ! pyochelin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0042865
name: pyochelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
synonym: "pyochelin breakdown" EXACT []
synonym: "pyochelin catabolism" EXACT []
synonym: "pyochelin degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042863 ! pyochelin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0042866
name: pyruvate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators]
synonym: "pyruvate anabolism" EXACT []
synonym: "pyruvate biosynthesis" EXACT []
synonym: "pyruvate formation" EXACT []
synonym: "pyruvate synthesis" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0042867
name: pyruvate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators]
synonym: "pyruvate breakdown" EXACT []
synonym: "pyruvate catabolism" EXACT []
synonym: "pyruvate degradation" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042868
name: antisense RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl]
synonym: "antisense RNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0042869
name: aldarate transmembrane transport
namespace: biological_process
def: "The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators]
synonym: "aldarate transport" RELATED []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0042870
name: D-glucarate transmembrane transport
namespace: biological_process
def: "The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "D-glucarate transport" RELATED []
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0042869 ! aldarate transmembrane transport

[Term]
id: GO:0042873
name: aldonate transmembrane transport
namespace: biological_process
def: "The process in which aldonate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl]
synonym: "aldonate transport" RELATED []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0042874
name: D-glucuronate transmembrane transport
namespace: biological_process
def: "The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "D-glucuronate transport" RELATED []
is_a: GO:0015738 ! glucuronate transmembrane transport

[Term]
id: GO:0042875
name: D-galactonate transmembrane transport
namespace: biological_process
def: "The process in which D-galactonate, the D-enantiomer of galactonate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "D-galactonate transport" RELATED []
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0042873 ! aldonate transmembrane transport

[Term]
id: GO:0042876
name: aldarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of aldarate from one side of a membrane to the other." [GOC:go_curators, PMID:15034926]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0042878
name: D-glucarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0042876 ! aldarate transmembrane transporter activity

[Term]
id: GO:0042879
name: aldonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of aldonate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0042880
name: D-glucuronate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0015135 ! glucuronate transmembrane transporter activity

[Term]
id: GO:0042881
name: D-galactonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0042882
name: L-arabinose transmembrane transport
namespace: biological_process
def: "The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "L-arabinose transport" RELATED []
is_a: GO:0015751 ! arabinose transmembrane transport

[Term]
id: GO:0042883
name: cysteine transport
namespace: biological_process
def: "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
synonym: "L-cysteine transport" NARROW []
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0042884
name: microcin transport
namespace: biological_process
def: "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337]
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0042885
name: microcin B17 transport
namespace: biological_process
def: "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337]
is_a: GO:0042884 ! microcin transport

[Term]
id: GO:0042886
name: amide transport
namespace: biological_process
def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0042887
name: amide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]
synonym: "amine/amide/polyamine channel activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0042888
name: molybdenum ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0042889
name: obsolete 3-phenylpropionic acid transport
namespace: biological_process
def: "OBSOLETE. The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "3-phenylpropionate transport" EXACT []
synonym: "HCA transport" EXACT []
synonym: "hydrocinnamic acid transport" EXACT []
is_obsolete: true

[Term]
id: GO:0042890
name: obsolete 3-phenylpropionic acid transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of 3-phenylpropionic acid from one side of a membrane to the other." [GOC:jl]
comment: The reason for obsoletion is that there is no evidence that this function exists.
synonym: "3-phenylpropionate acid transporter activity" EXACT []
synonym: "HCA transporter activity" EXACT []
synonym: "hydrocinnamic acid transporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0042891
name: obsolete antibiotic transport
namespace: biological_process
def: "OBSOLETE. The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
comment: The reason for obsoletion is that this term has been inconsistently used. For export of an antibiotic by the organism that synthesizes it, consider 'GO:0140115 ; export across plasma membrane'. For export of an antibiotic by the target organism, consider 'GO:1990961 ; xenobiotic detoxification by transmembrane export across the plasma membrane'.
is_obsolete: true

[Term]
id: GO:0042892
name: chloramphenicol transmembrane transport
namespace: biological_process
def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other." [PMID:29150447]
synonym: "chloramphenicol transport" BROAD []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0042893
name: polymyxin transport
namespace: biological_process
def: "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0006869 ! lipid transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0042894
name: fosmidomycin transport
namespace: biological_process
def: "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:12543685]
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0042895
name: obsolete antibiotic transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, from one side of a membrane to the other." [GOC:jl]
comment: The reason for obsoletion is that this term has been inconsistently used. Consider annotating to 'GO:0042910 ; xenobiotic transmembrane transporter activity' and the specific solute being transported as an annotation extension.
synonym: "antibiotic transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0042896
name: chloramphenicol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other." [GOC:jl]
synonym: "chloramphenicol transporter activity" RELATED []
is_a: GO:0015166 ! polyol transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0042897
name: polymyxin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]
synonym: "polymyxin transporter activity" RELATED []
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:0042898
name: fosmidomycin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other." [GOC:jl, PMID:12543685]
synonym: "fosmidomycin transporter activity" RELATED []
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0042899
name: arabinan transmembrane transport
namespace: biological_process
def: "The process in which arabinan is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl]
synonym: "arabinan transport" RELATED []
is_a: GO:0015774 ! polysaccharide transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0042900
name: arabinose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015146 ! pentose transmembrane transporter activity

[Term]
id: GO:0042901
name: arabinan transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0042902
name: obsolete peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein
namespace: biological_process
def: "OBSOLETE. The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0042903
name: tubulin deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003]
xref: Reactome:R-HSA-5618331 "HDAC6 deacetylates microtubules"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0033558 ! protein lysine deacetylase activity

[Term]
id: GO:0042904
name: 9-cis-retinoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]
synonym: "9-cis-retinoic acid anabolism" EXACT []
synonym: "9-cis-retinoic acid biosynthesis" EXACT []
synonym: "9-cis-retinoic acid formation" EXACT []
synonym: "9-cis-retinoic acid synthesis" EXACT []
is_a: GO:0002138 ! retinoic acid biosynthetic process
is_a: GO:0042905 ! 9-cis-retinoic acid metabolic process

[Term]
id: GO:0042905
name: 9-cis-retinoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]
synonym: "9-cis-retinoic acid metabolism" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process

[Term]
id: GO:0042906
name: xanthine transport
namespace: biological_process
def: "The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]
synonym: "xanthine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006863 ! purine nucleobase transport

[Term]
id: GO:0042907
name: xanthine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity

[Term]
id: GO:0042908
name: xenobiotic transport
namespace: biological_process
alt_id: GO:0015893
def: "The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators, GOC:krc]
subset: goslim_pir
synonym: "drug transport" RELATED []
is_a: GO:0006810 ! transport

[Term]
id: GO:0042909
name: obsolete acridine transport
namespace: biological_process
def: "OBSOLETE. The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, Wikipedia:Acridine]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:0042910
name: xenobiotic transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015238
alt_id: GO:0015239
alt_id: GO:0015559
alt_id: GO:0015564
alt_id: GO:0090484
def: "Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators, GOC:krc]
subset: goslim_metagenomics
synonym: "drug transmembrane transporter activity" RELATED []
synonym: "drug transporter activity" RELATED []
synonym: "multidrug efflux pump activity" RELATED []
synonym: "multidrug transporter activity" RELATED []
synonym: "multidrug, alkane resistant pump activity" RELATED []
synonym: "xenobiotic transporter activity" RELATED []
xref: Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+"
xref: Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0042911
name: obsolete acridine transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene from one side of a membrane to the other." [GOC:jl]
comment: The reason for obsoletion is that these terms are beyond the scope of GO.
synonym: "acridine transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0042912
name: colicin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:17347522]
is_a: GO:0022885 ! bacteriocin transmembrane transporter activity

[Term]
id: GO:0042913
name: group A colicin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417]
is_a: GO:0042912 ! colicin transmembrane transporter activity

[Term]
id: GO:0042914
name: colicin transport
namespace: biological_process
def: "The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, PMID:17347522]
is_a: GO:0043213 ! bacteriocin transport

[Term]
id: GO:0042915
name: group A colicin transport
namespace: biological_process
def: "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:9171417]
is_a: GO:0042914 ! colicin transport

[Term]
id: GO:0042918
name: alkanesulfonate transmembrane transport
namespace: biological_process
def: "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [PMID:31802112]
synonym: "alkanesulfonate transport" BROAD []
synonym: "alkanesulphonate transport" BROAD []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:1903825 ! organic acid transmembrane transport

[Term]
id: GO:0042919
name: benzoate transport
namespace: biological_process
def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0042920
name: 3-hydroxyphenylpropionic acid transmembrane transport
namespace: biological_process
def: "The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators, PMID:9098055]
synonym: "3-(3-hydroxyphenyl)propionic acid transport" EXACT []
synonym: "3-hydroxyphenylpropionic acid transport" BROAD []
synonym: "m-hydroxyphenylpropionic acid transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0042921
name: nuclear receptor-mediated glucocorticoid signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a glucocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah]
synonym: "glucocorticoid receptor signaling pathway" BROAD []
synonym: "glucocorticoid receptor signalling pathway" BROAD []
synonym: "intracellular glucocorticoid receptor signaling pathway" EXACT []
is_a: GO:0031958 ! nuclear receptor-mediated corticosteroid signaling pathway

[Term]
id: GO:0042922
name: neuromedin U receptor binding
namespace: molecular_function
def: "Binding to one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166]
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0042923
name: neuropeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [PMID:10414961, PMID:38337033]
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0042924
name: neuromedin U binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108]
synonym: "NMU binding" EXACT []
is_a: GO:0042923 ! neuropeptide binding

[Term]
id: GO:0042925
name: benzoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other." [GOC:jl, ISBN:0721662544]
synonym: "benzoate transporter activity" RELATED []
is_a: GO:0042910 ! xenobiotic transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0042926
name: 3-hydroxyphenylpropionic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other." [GOC:jl, PMID:9098055]
synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT []
synonym: "3-hydroxyphenylpropionic acid transporter activity" RELATED []
synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042910 ! xenobiotic transmembrane transporter activity

[Term]
id: GO:0042928
name: ferrichrome import into cell
namespace: biological_process
def: "A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732, PMID:23192658]
synonym: "ferrichrome transport" BROAD []
is_a: GO:0015687 ! ferric-hydroxamate import into cell
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0042929
name: ferrichrome transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732]
synonym: "ferrichrome transporter activity" RELATED []
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity
is_a: GO:0015603 ! iron chelate transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0042930
name: enterobactin transport
namespace: biological_process
def: "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "enterochelin transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport

[Term]
id: GO:0042931
name: enterobactin transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other." [GOC:jl]
synonym: "enterobactin transporter activity" RELATED []
synonym: "enterochelin transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0042932
name: chrysobactin transport
namespace: biological_process
def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport
is_a: GO:0042938 ! dipeptide transport
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0042933
name: chrysobactin transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other." [GOC:jl, PMID:8837459]
synonym: "chrysobactin transporter activity" RELATED []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0071916 ! dipeptide transmembrane transporter activity

[Term]
id: GO:0042934
name: achromobactin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other." [GOC:jl]
synonym: "achromobactin transporter activity" RELATED []
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0042935
name: achromobactin transport
namespace: biological_process
def: "The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:10928541]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport
is_a: GO:0042886 ! amide transport
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0042937
name: tripeptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other." [GOC:jl]
synonym: "tripeptide transporter activity" RELATED []
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity

[Term]
id: GO:0042938
name: dipeptide transport
namespace: biological_process
def: "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0006857 ! oligopeptide transport

[Term]
id: GO:0042939
name: tripeptide transport
namespace: biological_process
def: "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0006857 ! oligopeptide transport

[Term]
id: GO:0042940
name: D-amino acid transport
namespace: biological_process
def: "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0042941
name: D-alanine transmembrane transport
namespace: biological_process
def: "The process in which D-alanine, the D-enantiomer of 2-aminopropanoic acid,  is transported across a lipid bilayer, from one side of a membrane to the other by means of some agent such as a transporter or pore." [GO:ew, GOC:jl, GOC:jsg, GOC:mah]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0032328 ! alanine transport
is_a: GO:0042940 ! D-amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0042942
name: D-serine transmembrane transport
namespace: biological_process
def: "The process in which of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid is transported across a lipid bilayer, from one side of a membrane to the other, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0032329 ! serine transport
is_a: GO:0042940 ! D-amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0042943
name: D-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
synonym: "D-amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0042944
name: D-alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
synonym: "D-alanine transporter activity" BROAD []
is_a: GO:0022858 ! alanine transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity

[Term]
id: GO:0042945
name: D-serine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
synonym: "D-serine permease activity" EXACT []
synonym: "D-serine transporter activity" BROAD []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity

[Term]
id: GO:0042946
name: glucoside transport
namespace: biological_process
def: "The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, ISBN:0198506732]
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0042947
name: glucoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0042948
name: salicin transport
namespace: biological_process
def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0015759 ! beta-glucoside transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0042949
name: arbutin transport
namespace: biological_process
def: "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:19965875]
is_a: GO:0015759 ! beta-glucoside transport

[Term]
id: GO:0042950
name: salicin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0042951
name: arbutin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, PMID:19965875]
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity

[Term]
id: GO:0042952
name: beta-ketoadipate pathway
namespace: biological_process
def: "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091]
synonym: "ortho-cleavage pathway" BROAD []
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0042953
name: lipoprotein transport
namespace: biological_process
def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
is_a: GO:0015031 ! protein transport
is_a: GO:0044872 ! lipoprotein localization

[Term]
id: GO:0042954
name: obsolete lipoprotein transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is this term has been incorrectly used.
is_obsolete: true

[Term]
id: GO:0042955
name: dextrin transport
namespace: biological_process
def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0042956
name: maltodextrin transmembrane transport
namespace: biological_process
def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane." [GOC:jl]
synonym: "maltodextrin transport" BROAD []
is_a: GO:0042955 ! dextrin transport

[Term]
id: GO:0042957
name: dextrin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other." [GOC:jl, GOC:vk]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0042958
name: maltodextrin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other." [GOC:jl, PMID:15034926]
is_a: GO:0042957 ! dextrin transmembrane transporter activity

[Term]
id: GO:0042959
name: ABC-type alkanesulfonate transporter transporter activity
namespace: molecular_function
def: "Enables the transfer of an alkanesulfonate from one side of a membrane to the other according to the reaction: ATP + H2O + alkanesulfonate(out) = ADP + phosphate + alkanesulfonate(in)." [PMID:10506196]
synonym: "alkanesulfonate transmembrane transporter activity" BROAD []
synonym: "alkanesulfonate transporter activity" RELATED []
synonym: "alkanesulphonate transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0042960
name: antimonite secondary active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:jl]
synonym: "antimonite porter activity" RELATED []
is_a: GO:0015104 ! antimonite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0042961
name: ATPase-coupled antimonite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:7.3.2.7]
synonym: "antimonite-transporting ATPase activity" EXACT []
synonym: "ATP-dependent antimonite transporter activity" EXACT []
is_a: GO:0015104 ! antimonite transmembrane transporter activity
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity

[Term]
id: GO:0042962
name: acridine:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876]
synonym: "acridine efflux pump activity" RELATED []
synonym: "acridine:hydrogen antiporter activity" EXACT []
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0042964
name: obsolete thioredoxin reduction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the reduction of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "thioredoxin anabolism" EXACT []
synonym: "thioredoxin biosynthesis" EXACT []
synonym: "thioredoxin formation" EXACT []
synonym: "thioredoxin synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0042965
name: obsolete glutaredoxin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators]
comment: This term was made obsolete because it refers to the biosynthesis of a protein.
synonym: "glutaredoxin anabolism" EXACT []
synonym: "glutaredoxin biosynthesis" EXACT []
synonym: "glutaredoxin formation" EXACT []
synonym: "glutaredoxin synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0042966
name: biotin carboxyl carrier protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363]
synonym: "BCCP biosynthesis" EXACT []
synonym: "BCCP biosynthetic process" EXACT []
synonym: "biotin carboxyl carrier protein anabolism" EXACT []
synonym: "biotin carboxyl carrier protein biosynthesis" EXACT []
synonym: "biotin carboxyl carrier protein formation" EXACT []
synonym: "biotin carboxyl carrier protein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0042967
name: obsolete acyl-carrier-protein biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators]
comment: The reason for obsoletion is that acyl-carrier-protein is synthesized by the ribosome like any other protein.
synonym: "ACP biosynthesis" EXACT []
synonym: "ACP biosynthetic process" EXACT []
synonym: "acyl carrier protein biosynthesis" EXACT []
synonym: "acyl carrier protein biosynthetic process" EXACT []
synonym: "acyl-carrier protein biosynthesis" EXACT []
synonym: "acyl-carrier-protein anabolism" EXACT []
synonym: "acyl-carrier-protein biosynthesis" EXACT []
synonym: "acyl-carrier-protein formation" EXACT []
synonym: "acyl-carrier-protein synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0042968
name: homoserine transport
namespace: biological_process
def: "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0042969
name: obsolete lactone transport
namespace: biological_process
def: "OBSOLETE. The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:go_curators]
comment: This term aws obsoleted because there is no evidence for a specific pathway to transport lactone.
is_obsolete: true

[Term]
id: GO:0042970
name: homoserine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732]
synonym: "homoserine transporter activity" BROAD []
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0042971
name: obsolete lactone transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:go_curators]
comment: This term was obsoleted because there is no evidence for a specific lactone transporter.
is_obsolete: true

[Term]
id: GO:0042972
name: licheninase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds." [EC:3.2.1.73]
synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT []
synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT []
synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.73]
synonym: "1,3;1,4-beta-glucan endohydrolase activity" RELATED [EC:3.2.1.73]
synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.73]
synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73]
synonym: "endo-beta-1,3-1,4 glucanase activity" RELATED [EC:3.2.1.73]
synonym: "lichenase activity" EXACT []
synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73]
xref: EC:3.2.1.73
xref: MetaCyc:3.2.1.73-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0042973
name: glucan endo-1,3-beta-D-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans." [EC:3.2.1.39]
synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" RELATED [EC:3.2.1.39]
synonym: "(1->3)-beta-glucan endohydrolase activity" RELATED [EC:3.2.1.39]
synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" RELATED [EC:3.2.1.39]
synonym: "1,3-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.39]
synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39]
synonym: "callase activity" RELATED [EC:3.2.1.39]
synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39]
synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39]
synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39]
synonym: "endo-1,3-beta-glucanase activity" BROAD []
synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39]
synonym: "kitalase activity" RELATED [EC:3.2.1.39]
synonym: "laminaranase activity" BROAD []
synonym: "laminarinase activity" BROAD []
synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39]
xref: EC:3.2.1.39
xref: MetaCyc:3.2.1.39-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0042974
name: nuclear retinoic acid receptor binding
namespace: molecular_function
def: "Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796]
synonym: "RAR binding" EXACT []
synonym: "retinoic acid receptor binding" BROAD []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0042975
name: peroxisome proliferator activated receptor binding
namespace: molecular_function
def: "Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma." [GOC:jl, PMID:12769781]
synonym: "PPAR binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0042976
name: activation of Janus kinase activity
namespace: biological_process
alt_id: GO:0010531
alt_id: GO:0042977
def: "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803]
subset: gocheck_obsoletion_candidate
synonym: "activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "activation of JAK protein by tyrosine phosphorylation" EXACT []
synonym: "activation of JAK1 kinase activity" NARROW []
synonym: "activation of JAK1 protein" NARROW [GOC:dph, GOC:tb]
synonym: "activation of JAK2 kinase activity" NARROW []
synonym: "activation of JAK2 protein" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" EXACT []
synonym: "tyrosine phosphorylation of JAK protein" EXACT []
synonym: "tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb]
synonym: "tyrosine phosphorylation of JAK2 protein" NARROW []
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
is_a: GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0046427 ! positive regulation of receptor signaling pathway via JAK-STAT

[Term]
id: GO:0042978
name: ornithine decarboxylase activator activity
namespace: molecular_function
def: "Binds to and increases ornithine decarboxylase activity." [GOC:jl]
synonym: "L-ornithine carboxy-lyase activator activity" NARROW []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0042979 ! ornithine decarboxylase regulator activity

[Term]
id: GO:0042979
name: ornithine decarboxylase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of the enzyme ornithine decarboxylase." [GOC:jl]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0042980
name: obsolete cystic fibrosis transmembrane conductance regulator binding
namespace: molecular_function
def: "OBSOLETE. Binding to a Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "CFTR binding" EXACT []
synonym: "cystic fibrosis transmembrane conductance regulator binding" EXACT []
is_obsolete: true
replaced_by: GO:0044325

[Term]
id: GO:0042981
name: regulation of apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "apoptosis regulator activity" RELATED []
synonym: "regulation of apoptosis" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
relationship: regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0042982
name: amyloid precursor protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
synonym: "amyloid precursor protein metabolism" EXACT []
synonym: "APP metabolic process" EXACT []
synonym: "APP metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0042983
name: amyloid precursor protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
synonym: "amyloid precursor protein anabolism" EXACT []
synonym: "amyloid precursor protein biosynthesis" EXACT []
synonym: "amyloid precursor protein formation" EXACT []
synonym: "amyloid precursor protein synthesis" EXACT []
synonym: "APP biosynthesis" EXACT []
synonym: "APP biosynthetic process" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0042982 ! amyloid precursor protein metabolic process

[Term]
id: GO:0042984
name: regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]
synonym: "regulation of amyloid precursor protein anabolism" EXACT []
synonym: "regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "regulation of amyloid precursor protein formation" EXACT []
synonym: "regulation of amyloid precursor protein synthesis" EXACT []
synonym: "regulation of APP biosynthesis" EXACT []
synonym: "regulation of APP biosynthetic process" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042985
name: negative regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]
synonym: "down regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "down-regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "downregulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "inhibition of amyloid precursor protein biosynthetic process" NARROW []
synonym: "negative regulation of amyloid precursor protein anabolism" EXACT []
synonym: "negative regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "negative regulation of amyloid precursor protein formation" EXACT []
synonym: "negative regulation of amyloid precursor protein synthesis" EXACT []
synonym: "negative regulation of APP biosynthesis" EXACT []
synonym: "negative regulation of APP biosynthetic process" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process
relationship: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042986
name: positive regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]
synonym: "activation of amyloid precursor protein biosynthetic process" NARROW []
synonym: "positive regulation of amyloid precursor protein anabolism" EXACT []
synonym: "positive regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "positive regulation of amyloid precursor protein formation" EXACT []
synonym: "positive regulation of amyloid precursor protein synthesis" EXACT []
synonym: "positive regulation of APP biosynthesis" EXACT []
synonym: "positive regulation of APP biosynthetic process" EXACT []
synonym: "stimulation of amyloid precursor protein biosynthetic process" NARROW []
synonym: "up regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "up-regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "upregulation of amyloid precursor protein biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process
relationship: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042987
name: amyloid precursor protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
synonym: "amyloid precursor protein breakdown" EXACT []
synonym: "amyloid precursor protein catabolism" EXACT []
synonym: "amyloid precursor protein degradation" EXACT []
synonym: "APP catabolic process" EXACT []
synonym: "APP catabolism" EXACT []
is_a: GO:0042982 ! amyloid precursor protein metabolic process

[Term]
id: GO:0042988
name: X11-like protein binding
namespace: molecular_function
def: "Binding to X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348]
synonym: "X11L binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042989
name: obsolete sequestering of actin monomers
namespace: biological_process
def: "OBSOLETE. The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators]
comment: The reason for obsoletion is that this term represents a molecular function, not biological process
synonym: "actin monomer retention" EXACT []
synonym: "actin monomer sequestering" EXACT []
synonym: "actin monomer sequestering activity" RELATED []
synonym: "actin monomer sequestration" EXACT []
synonym: "actin monomer storage" EXACT []
synonym: "retention of actin monomers" EXACT []
synonym: "sequestration of actin monomers" EXACT []
synonym: "storage of actin monomers" EXACT []
is_obsolete: true
consider: GO:0140311

[Term]
id: GO:0042990
name: obsolete regulation of transcription factor import into nucleus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
synonym: "regulation of transcription factor import into cell nucleus" EXACT []
synonym: "regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of transcription factor-nucleus import" EXACT []
is_obsolete: true
consider: GO:0042306

[Term]
id: GO:0042991
name: obsolete transcription factor import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
synonym: "transcription factor import into cell nucleus" EXACT []
synonym: "transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "transcription factor-nucleus import" EXACT []
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0042992
name: obsolete negative regulation of transcription factor import into nucleus
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
synonym: "down regulation of transcription factor import into nucleus" EXACT []
synonym: "down-regulation of transcription factor import into nucleus" EXACT []
synonym: "downregulation of transcription factor import into nucleus" EXACT []
synonym: "inhibition of transcription factor import into nucleus" NARROW []
synonym: "negative regulation of transcription factor import into cell nucleus" EXACT []
synonym: "negative regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of transcription factor-nucleus import" EXACT []
is_obsolete: true
consider: GO:0042308

[Term]
id: GO:0042993
name: obsolete positive regulation of transcription factor import into nucleus
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
synonym: "activation of transcription factor import into nucleus" NARROW []
synonym: "positive regulation of transcription factor import into cell nucleus" EXACT []
synonym: "positive regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of transcription factor-nucleus import" EXACT []
synonym: "stimulation of transcription factor import into nucleus" NARROW []
synonym: "up regulation of transcription factor import into nucleus" EXACT []
synonym: "up-regulation of transcription factor import into nucleus" EXACT []
synonym: "upregulation of transcription factor import into nucleus" EXACT []
is_obsolete: true
consider: GO:0042307

[Term]
id: GO:0042994
name: obsolete cytoplasmic sequestering of transcription factor
namespace: biological_process
def: "OBSOLETE. The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
comment: The reason for obsoletion is that this term represents a molecular function, not biological process.
synonym: "cytoplasmic retention of transcription factor" EXACT []
synonym: "cytoplasmic sequestration of transcription factor" EXACT []
synonym: "cytoplasmic storage of transcription factor" EXACT []
synonym: "maintenance of transcription factor protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of transcription factor in cytoplasm" EXACT []
synonym: "sequestering of transcription factor in cytoplasm" EXACT []
synonym: "sequestration of transcription factor in cytoplasm" EXACT []
synonym: "storage of transcription factor in cytoplasm" EXACT []
synonym: "transcription factor binding, cytoplasmic sequestering" EXACT []
is_obsolete: true

[Term]
id: GO:0042995
name: cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]
subset: goslim_agr
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "cell process" BROAD []
synonym: "cellular process" BROAD []
synonym: "cellular projection" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0042996
name: regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042997
name: negative regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042998
name: positive regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "activation of Golgi to plasma membrane protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042999
name: obsolete regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
comment: This term was made obsolete because it involved a specific gene product.
is_obsolete: true

[Term]
id: GO:0043000
name: obsolete Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "OBSOLETE. The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
comment: This term was made obsolete because it involved a specific gene product.
synonym: "Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport" EXACT []
is_obsolete: true
replaced_by: GO:0043001

[Term]
id: GO:0043001
name: Golgi to plasma membrane protein transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]
is_a: GO:0006893 ! Golgi to plasma membrane transport
is_a: GO:0015031 ! protein transport
is_a: GO:0061951 ! establishment of protein localization to plasma membrane

[Term]
id: GO:0043002
name: obsolete negative regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
comment: This term was made obsolete because it involved a specific gene product.
synonym: "down regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane CFTR protein transport" NARROW []
is_obsolete: true

[Term]
id: GO:0043003
name: obsolete positive regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
comment: This term was made obsolete because it involved a specific gene product.
synonym: "activation of Golgi to plasma membrane CFTR protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane CFTR protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane CFTR protein transport" EXACT []
is_obsolete: true

[Term]
id: GO:0043004
name: obsolete cytoplasmic sequestering of CFTR protein
namespace: biological_process
def: "OBSOLETE. The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl]
comment: This term was made obsolete because it involved a specific gene product.
synonym: "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT []
synonym: "cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein" EXACT []
synonym: "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)" EXACT []
synonym: "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT []
synonym: "maintenance of CFTR protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT []
synonym: "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT []
synonym: "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT []
synonym: "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT []
is_obsolete: true

[Term]
id: GO:0043005
name: neuron projection
namespace: cellular_component
def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]
subset: goslim_pir
synonym: "nerve fiber" RELATED [GOC:dph]
synonym: "neurite" NARROW []
synonym: "neuron process" EXACT []
synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889]
synonym: "neuronal cell projection" EXACT []
xref: NIF_Subcellular:sao867568886
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0043006
name: obsolete activation of phospholipase A2 activity by calcium-mediated signaling
namespace: biological_process
def: "OBSOLETE. The series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:dph, GOC:jl, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of phospholipase A2 activity by calcium-mediated signalling" EXACT [GOC:mah]
synonym: "calcium-dependent activation of phospholipase A2" EXACT [GOC:dph, GOC:tb]
synonym: "calcium-dependent phospholipase A2 activation" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0043007
name: maintenance of rDNA
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010]
synonym: "rDNA maintenance" EXACT []
synonym: "ribosomal DNA maintenance" EXACT []
is_a: GO:0043570 ! maintenance of DNA repeat elements

[Term]
id: GO:0043008
name: ATP-dependent protein binding
namespace: molecular_function
def: "Binding to a protein or protein complex using energy from ATP hydrolysis." [GOC:jl]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043009
name: chordate embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0043010
name: camera-type eye development
namespace: biological_process
alt_id: GO:0001747
alt_id: GO:0031075
def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0043011
name: myeloid dendritic cell differentiation
namespace: biological_process
def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl]
xref: Wikipedia:Dendritic_cell
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:0043012
name: regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def: "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, PMID:11483596]
synonym: "regulation of sperm-oocyte fusion" NARROW []
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:1903729 ! regulation of plasma membrane organization
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization

[Term]
id: GO:0043013
name: negative regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def: "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, PMID:34459848]
synonym: "down regulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "down-regulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "downregulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "inhibition of fusion of sperm to egg plasma membrane" NARROW []
synonym: "inhibition of sperm-oocyte fusion" NARROW []
synonym: "negative regulation of sperm-oocyte fusion" NARROW []
is_a: GO:0043012 ! regulation of fusion of sperm to egg plasma membrane
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization

[Term]
id: GO:0043014
name: alpha-tubulin binding
namespace: molecular_function
def: "Binding to the microtubule constituent protein alpha-tubulin." [GOC:jl]
synonym: "alpha tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0043015
name: gamma-tubulin binding
namespace: molecular_function
def: "Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]
synonym: "gamma tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0043020
name: NADPH oxidase complex
namespace: cellular_component
def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]
synonym: "flavocytochrome b558" NARROW []
synonym: "respiratory-burst oxidase" RELATED []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0043021
name: ribonucleoprotein complex binding
namespace: molecular_function
def: "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]
subset: goslim_pir
synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk]
synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk]
synonym: "RNP binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0043022
name: ribosome binding
namespace: molecular_function
alt_id: GO:0030376
def: "Binding to a ribosome." [GOC:go_curators]
synonym: "ribosome receptor activity" NARROW []
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0043023
name: ribosomal large subunit binding
namespace: molecular_function
def: "Binding to a large ribosomal subunit." [GOC:go_curators]
is_a: GO:0043022 ! ribosome binding

[Term]
id: GO:0043024
name: ribosomal small subunit binding
namespace: molecular_function
def: "Binding to a small ribosomal subunit." [GOC:go_curators]
is_a: GO:0043022 ! ribosome binding

[Term]
id: GO:0043025
name: neuronal cell body
namespace: cellular_component
def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "neuron cell body" EXACT []
synonym: "neuronal cell soma" EXACT []
xref: NIF_Subcellular:sao1044911821
xref: Wikipedia:Soma_(biology)
is_a: GO:0044297 ! cell body
relationship: part_of GO:0036477 ! somatodendritic compartment

[Term]
id: GO:0043027
name: cysteine-type endopeptidase inhibitor activity involved in apoptotic process
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]
synonym: "caspase inhibitor activity" BROAD []
is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process

[Term]
id: GO:0043028
name: cysteine-type endopeptidase regulator activity involved in apoptotic process
namespace: molecular_function
def: "Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]
synonym: "caspase regulator activity" BROAD []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0043029
name: T cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149]
comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "T lymphocyte homeostasis" EXACT []
synonym: "T-cell homeostasis" EXACT []
synonym: "T-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0043030
name: regulation of macrophage activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl]
synonym: "regulation of macrophage polarization" EXACT []
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043031
name: negative regulation of macrophage activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl]
synonym: "down regulation of macrophage activation" EXACT []
synonym: "down-regulation of macrophage activation" EXACT []
synonym: "downregulation of macrophage activation" EXACT []
synonym: "inhibition of macrophage activation" NARROW []
synonym: "negative regulation of macrophage polarization" EXACT []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
relationship: negatively_regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043032
name: positive regulation of macrophage activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl]
synonym: "activation of macrophage activation" NARROW []
synonym: "positive regulation of macrophage polarization" EXACT []
synonym: "stimulation of macrophage activation" NARROW []
synonym: "up regulation of macrophage activation" EXACT []
synonym: "up-regulation of macrophage activation" EXACT []
synonym: "upregulation of macrophage activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
relationship: positively_regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043033
name: isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591]
subset: goslim_pir
synonym: "debranching enzyme complex" BROAD []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0043034
name: costamere
namespace: cellular_component
def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]
xref: Wikipedia:Costamere
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0043035
name: chromatin insulator sequence binding
namespace: molecular_function
def: "Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]
is_a: GO:0031490 ! chromatin DNA binding

[Term]
id: GO:0043036
name: starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
synonym: "starch granule" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0043038
name: amino acid activation
namespace: biological_process
def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl]
is_a: GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0043039
name: tRNA aminoacylation
namespace: biological_process
def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah]
synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah]
synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah]
synonym: "tRNA charging" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0043038 ! amino acid activation

[Term]
id: GO:0043040
name: tRNA aminoacylation for nonribosomal peptide biosynthetic process
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl]
synonym: "tRNA aminoacylation for nonribosomal peptide anabolism" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide biosynthesis" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide formation" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide synthesis" EXACT []
is_a: GO:0043039 ! tRNA aminoacylation
is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process

[Term]
id: GO:0043041
name: amino acid activation for nonribosomal peptide biosynthetic process
namespace: biological_process
def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl]
synonym: "nonribosomal amino acid activation" RELATED []
is_a: GO:0043038 ! amino acid activation
relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process

[Term]
id: GO:0043042
name: amino acid adenylylation by nonribosomal peptide synthase
namespace: biological_process
def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910]
synonym: "amino acid adenylation by nonribosomal peptide synthase" EXACT []
synonym: "amino acid adenylation by NRPS" EXACT []
is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process

[Term]
id: GO:0043043
name: peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl]
synonym: "peptide anabolism" EXACT []
synonym: "peptide biosynthesis" EXACT []
synonym: "peptide formation" EXACT []
synonym: "peptide synthesis" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0043045
name: epigenetic programming of gene expression
namespace: biological_process
def: "A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation." [GOC:go_curators, PMID:12138111, PMID:22868271]
synonym: "de novo DNA methylation" RELATED []
synonym: "DNA methylation involved in embryo development" RELATED []
synonym: "epigenetic regulation of embryonic gene expression" RELATED []
synonym: "post-fertilization epigenetic regulation of gene expression" RELATED []
is_a: GO:0040029 ! epigenetic regulation of gene expression

[Term]
id: GO:0043046
name: obsolete DNA methylation involved in gamete generation
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete." [GOC:go_curators, PMID:12138111]
comment: This term was obsoleted because it represent the same process as genomic imprinting ; GO:0071514 .
synonym: "de novo DNA methylation" RELATED []
is_obsolete: true
replaced_by: GO:0071514

[Term]
id: GO:0043047
name: single-stranded telomeric DNA binding
namespace: molecular_function
def: "Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]
synonym: "telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0042162 ! telomeric DNA binding
is_a: GO:0098847 ! sequence-specific single stranded DNA binding

[Term]
id: GO:0043048
name: dolichyl monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl]
synonym: "dolichyl monophosphate anabolism" EXACT []
synonym: "dolichyl monophosphate biosynthesis" EXACT []
synonym: "dolichyl monophosphate formation" EXACT []
synonym: "dolichyl monophosphate synthesis" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0043049
name: otic placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0030916 ! otic vesicle formation

[Term]
id: GO:0043050
name: nematode pharyngeal pumping
namespace: biological_process
def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052]
synonym: "pumping behavior" RELATED []
is_a: GO:0042755 ! eating behavior

[Term]
id: GO:0043051
name: regulation of nematode pharyngeal pumping
namespace: biological_process
def: "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052]
is_a: GO:1903998 ! regulation of eating behavior
relationship: regulates GO:0043050 ! nematode pharyngeal pumping

[Term]
id: GO:0043052
name: thermotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
synonym: "taxis in response to temperature stimulus" EXACT []
xref: Wikipedia:Thermotaxis
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0042330 ! taxis

[Term]
id: GO:0043053
name: dauer entry
namespace: biological_process
def: "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, GOC:kmv, PMID:10077613]
synonym: "nematode entry into dormancy" EXACT []
is_a: GO:0055115 ! entry into diapause
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043054
name: dauer exit
namespace: biological_process
def: "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986]
synonym: "exit from nematode dormancy" EXACT []
is_a: GO:0071981 ! exit from diapause
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043055
name: maintenance of dauer
namespace: biological_process
def: "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740]
synonym: "maintenance of dormancy in the nematode" EXACT []
is_a: GO:0071982 ! maintenance of diapause
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043056
name: forward locomotion
namespace: biological_process
def: "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators]
is_a: GO:0033058 ! directional locomotion

[Term]
id: GO:0043057
name: backward locomotion
namespace: biological_process
def: "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators]
is_a: GO:0033058 ! directional locomotion

[Term]
id: GO:0043058
name: regulation of backward locomotion
namespace: biological_process
def: "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators]
is_a: GO:0040012 ! regulation of locomotion
relationship: regulates GO:0043057 ! backward locomotion

[Term]
id: GO:0043059
name: regulation of forward locomotion
namespace: biological_process
def: "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators]
is_a: GO:0040012 ! regulation of locomotion
relationship: regulates GO:0043056 ! forward locomotion

[Term]
id: GO:0043060
name: meiotic metaphase I homologous chromosome alignment
namespace: biological_process
def: "A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [PMID:10809666]
synonym: "meiotic metaphase I chromosome alignment" EXACT []
is_a: GO:0051311 ! meiotic metaphase chromosome alignment
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0043061
name: meiotic metaphase II chromosome alignment
namespace: biological_process
def: "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during meiosis II chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [PMID:10809666]
is_a: GO:0051311 ! meiotic metaphase chromosome alignment
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0043062
name: extracellular structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: goslim_prokaryote
synonym: "extracellular structure organisation" EXACT []
synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043063
name: intercellular bridge organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid]
synonym: "intercellular bridge organisation" EXACT []
synonym: "intercellular bridge organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization

[Term]
id: GO:0043064
name: obsolete flagellum organization
namespace: biological_process
def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:curators, ISBN:0815316194]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "flagellum organisation" EXACT []
synonym: "flagellum organization" EXACT []
synonym: "flagellum organization and biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0044781
consider: GO:0044782

[Term]
id: GO:0043065
name: positive regulation of apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
subset: goslim_chembl
synonym: "activation of apoptosis" NARROW []
synonym: "positive regulation of apoptosis" NARROW []
synonym: "pro-apoptosis" RELATED []
synonym: "stimulation of apoptosis" NARROW []
synonym: "up regulation of apoptosis" EXACT []
synonym: "up-regulation of apoptosis" EXACT []
synonym: "upregulation of apoptosis" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043068 ! positive regulation of programmed cell death
relationship: positively_regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0043066
name: negative regulation of apoptotic process
namespace: biological_process
alt_id: GO:0006916
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "anti-apoptosis" EXACT []
synonym: "apoptosis inhibitor activity" RELATED []
synonym: "down regulation of apoptosis" EXACT []
synonym: "down-regulation of apoptosis" EXACT []
synonym: "downregulation of apoptosis" EXACT []
synonym: "inhibition of apoptosis" NARROW []
synonym: "negative regulation of apoptosis" NARROW []
synonym: "pro-survival" RELATED []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043069 ! negative regulation of programmed cell death
relationship: negatively_regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0043067
name: regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043070
def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043068
name: positive regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043071
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "activation of programmed cell death" NARROW []
synonym: "positive regulation of non-apoptotic programmed cell death" NARROW []
synonym: "stimulation of programmed cell death" NARROW []
synonym: "up regulation of programmed cell death" EXACT []
synonym: "up-regulation of programmed cell death" EXACT []
synonym: "upregulation of programmed cell death" EXACT []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043069
name: negative regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043072
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "down regulation of programmed cell death" EXACT []
synonym: "down-regulation of programmed cell death" EXACT []
synonym: "downregulation of programmed cell death" EXACT []
synonym: "inhibition of programmed cell death" NARROW []
synonym: "negative regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043073
name: germ cell nucleus
namespace: cellular_component
def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators]
synonym: "germ-cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043075
name: obsolete sperm cell nucleus (sensu Magnoliophyta)
namespace: cellular_component
def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl]
comment: This term was made obsolete because the definition was incorrect.
synonym: "pollen germ cell nucleus" EXACT []
synonym: "pollen germ-cell nucleus" EXACT []
synonym: "sperm cell nucleus (sensu Magnoliophyta)" EXACT []
is_obsolete: true
consider: GO:0048555

[Term]
id: GO:0043076
name: megasporocyte nucleus
namespace: cellular_component
def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153]
synonym: "megaspore mother cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043077
name: initiation of acetate catabolic process
namespace: biological_process
def: "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl]
synonym: "initiation of acetate breakdown" EXACT []
synonym: "initiation of acetate catabolism" EXACT []
synonym: "initiation of acetate degradation" EXACT []
is_a: GO:0045754 ! positive regulation of acetate catabolic process

[Term]
id: GO:0043078
name: polar nucleus
namespace: cellular_component
def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043079
name: antipodal cell nucleus
namespace: cellular_component
def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [CL:0000537, GOC:jl]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043082
name: megagametophyte egg cell nucleus
namespace: cellular_component
def: "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043083
name: synaptic cleft
namespace: cellular_component
def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, PMID:30784960]
subset: goslim_synapse
xref: NIF_Subcellular:sao243541954
is_a: GO:0005576 ! extracellular region

[Term]
id: GO:0043084
name: penile erection
namespace: biological_process
def: "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, Wikipedia:Penile_erection]
xref: Wikipedia:Erection#Penile_erection
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007620 ! copulation

[Term]
id: GO:0043085
name: positive regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048554
def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]
subset: gocheck_obsoletion_candidate
subset: goslim_chembl
synonym: "activation of enzyme activity" NARROW []
synonym: "activation of metalloenzyme activity" NARROW []
synonym: "positive regulation of enzyme activity" EXACT [GOC:tb]
synonym: "positive regulation of metalloenzyme activity" NARROW []
synonym: "stimulation of enzyme activity" NARROW []
synonym: "stimulation of metalloenzyme activity" NARROW []
synonym: "up regulation of enzyme activity" EXACT []
synonym: "up regulation of metalloenzyme activity" NARROW []
synonym: "up-regulation of enzyme activity" EXACT []
synonym: "up-regulation of metalloenzyme activity" NARROW []
synonym: "upregulation of enzyme activity" EXACT []
synonym: "upregulation of metalloenzyme activity" NARROW []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0043086
name: negative regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048553
def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of enzyme activity" EXACT []
synonym: "down regulation of metalloenzyme activity" NARROW []
synonym: "down-regulation of enzyme activity" EXACT []
synonym: "down-regulation of metalloenzyme activity" EXACT []
synonym: "downregulation of enzyme activity" EXACT []
synonym: "downregulation of metalloenzyme activity" NARROW []
synonym: "inhibition of enzyme activity" NARROW []
synonym: "inhibition of metalloenzyme activity" NARROW []
synonym: "negative regulation of enzyme activity" EXACT [GOC:tb]
synonym: "negative regulation of metalloenzyme activity" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0043087
name: regulation of GTPase activity
namespace: biological_process
alt_id: GO:0032312
alt_id: GO:0032313
alt_id: GO:0032314
alt_id: GO:0032315
alt_id: GO:0032316
alt_id: GO:0032317
alt_id: GO:0032318
alt_id: GO:0032319
alt_id: GO:0043088
def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
synonym: "regulation of ARF GTPase activity" NARROW []
synonym: "regulation of Cdc42 GTPase activity" NARROW []
synonym: "regulation of Rab GTPase activity" NARROW []
synonym: "regulation of Rac GTPase activity" NARROW []
synonym: "regulation of Ral GTPase activity" NARROW []
synonym: "regulation of Ran GTPase activity" NARROW []
synonym: "regulation of Rap GTPase activity" NARROW []
synonym: "regulation of Ras GTPase activity" NARROW []
synonym: "regulation of Rho GTPase activity" NARROW []
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0043090
name: amino acid import
namespace: biological_process
def: "The directed movement of amino acids into a cell or organelle." [GOC:jl]
synonym: "amino acid uptake" EXACT []
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0043093
name: FtsZ-dependent cytokinesis
namespace: biological_process
def: "A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells." [GOC:mah, ISBN:0815108893, PMID:12626683]
comment: Note that this term is intended for the annotation of prokaryotic gene products.
synonym: "cytokinesis by binary fission" RELATED [GOC:dph]
synonym: "prokaryote-type cytokinesis" RELATED [GOC:mah]
synonym: "prokaryotic fission" RELATED [Wikipedia:Binary_fission]
xref: Wikipedia:Binary_fission
is_a: GO:0000910 ! cytokinesis
is_a: GO:0022413 ! reproductive process in single-celled organism
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0043094
name: cellular metabolic compound salvage
namespace: biological_process
def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg]
subset: goslim_pir
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0043095
name: regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0043096
name: purine nucleobase salvage
namespace: biological_process
def: "Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [GOC:jl]
synonym: "purine base salvage" EXACT [GOC:go_curators]
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0043101 ! purine-containing compound salvage

[Term]
id: GO:0043097
name: pyrimidine nucleoside salvage
namespace: biological_process
def: "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl]
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0043098
name: purine deoxyribonucleoside salvage
namespace: biological_process
def: "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
is_a: GO:0043101 ! purine-containing compound salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0043099
name: pyrimidine deoxyribonucleoside salvage
namespace: biological_process
def: "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
is_a: GO:0043097 ! pyrimidine nucleoside salvage
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0043100
name: pyrimidine nucleobase salvage
namespace: biological_process
def: "Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [GOC:jl]
synonym: "pyrimidine base salvage" EXACT [GOC:go_curators]
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process

[Term]
id: GO:0043101
name: purine-containing compound salvage
namespace: biological_process
def: "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [GOC:jl]
subset: goslim_pir
synonym: "purine salvage" RELATED []
is_a: GO:0043094 ! cellular metabolic compound salvage
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0043102
name: amino acid salvage
namespace: biological_process
def: "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl]
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0043103
name: hypoxanthine salvage
namespace: biological_process
def: "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732]
synonym: "adenine, hypoxanthine and their nucleoside salvage" NARROW []
synonym: "guanine, xanthine and their nucleoside salvage" NARROW []
is_a: GO:0043096 ! purine nucleobase salvage
is_a: GO:0046101 ! hypoxanthine biosynthetic process

[Term]
id: GO:0043104
name: obsolete positive regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of GTP cyclohydrolase I activity" NARROW []
synonym: "stimulation of GTP cyclohydrolase I activity" NARROW []
synonym: "up regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "up-regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "upregulation of GTP cyclohydrolase I activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043105
name: obsolete negative regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "down-regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "downregulation of GTP cyclohydrolase I activity" EXACT []
synonym: "inhibition of GTP cyclohydrolase I activity" NARROW []
is_obsolete: true

[Term]
id: GO:0043107
name: type IV pilus-dependent motility
namespace: biological_process
def: "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238]
synonym: "social gliding motility" NARROW []
synonym: "TFP-dependent motility" EXACT []
synonym: "TFP-dependent movement" EXACT []
synonym: "twitching motility" NARROW []
synonym: "type 4 pilus-dependent motility" EXACT []
synonym: "type four pilus-dependent motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0043108
name: pilus retraction
namespace: biological_process
def: "The process of withdrawing a pilus back into a cell." [GOC:go_curators, PMID:17355871]
is_a: GO:0043711 ! pilus organization

[Term]
id: GO:0043110
name: rDNA spacer replication fork barrier binding
namespace: molecular_function
def: "Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529]
synonym: "RFB binding" EXACT []
is_a: GO:0000182 ! rDNA binding
is_a: GO:0031634 ! replication fork barrier binding

[Term]
id: GO:0043111
name: replication fork arrest
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected." [GOC:jl, GOC:pr, PMID:14645529]
comment: See also the biological process term 'site-specific replication termination ; GO:0071170' and its children.
synonym: "negative regulation of DNA replication at replication fork barrier" EXACT [GOC:dph, GOC:tb]
synonym: "replication fork blocking" EXACT []
synonym: "replication fork stalling" EXACT []
is_a: GO:0045005 ! DNA-templated DNA replication maintenance of fidelity
is_a: GO:2000104 ! negative regulation of DNA-templated DNA replication

[Term]
id: GO:0043112
name: receptor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl]
synonym: "receptor metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0043113
name: receptor clustering
namespace: biological_process
def: "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]
is_a: GO:0072657 ! protein localization to membrane

[Term]
id: GO:0043114
name: regulation of vascular permeability
namespace: biological_process
def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0043115
name: precorrin-2 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15613]
synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT []
synonym: "CysG" RELATED [EC:1.3.1.76]
synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT []
synonym: "Met8p" RELATED [EC:1.3.1.76]
synonym: "precorrin-2 oxidase activity" RELATED [EC:1.3.1.76]
synonym: "precorrin-2:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.76]
synonym: "SirC" RELATED [EC:1.3.1.76]
synonym: "siroheme synthase activity" BROAD []
xref: EC:1.3.1.76
xref: KEGG_REACTION:R03947
xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN
xref: RHEA:15613
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043116
name: negative regulation of vascular permeability
namespace: biological_process
def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
synonym: "down regulation of vascular permeability" EXACT []
synonym: "down-regulation of vascular permeability" EXACT []
synonym: "downregulation of vascular permeability" EXACT []
synonym: "inhibition of vascular permeability" NARROW []
is_a: GO:0043114 ! regulation of vascular permeability

[Term]
id: GO:0043117
name: positive regulation of vascular permeability
namespace: biological_process
def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
synonym: "activation of vascular permeability" NARROW []
synonym: "stimulation of vascular permeability" NARROW []
synonym: "up regulation of vascular permeability" EXACT []
synonym: "up-regulation of vascular permeability" EXACT []
synonym: "upregulation of vascular permeability" EXACT []
is_a: GO:0043114 ! regulation of vascular permeability

[Term]
id: GO:0043120
name: tumor necrosis factor binding
namespace: molecular_function
def: "Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0043121
name: neurotrophin binding
namespace: molecular_function
alt_id: GO:0048404
alt_id: GO:0048405
def: "Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl]
comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
synonym: "neurotrophic factor binding" EXACT [GOC:aruk, GOC:bc]
synonym: "neurotrophin 3 binding" NARROW []
synonym: "neurotrophin 4/5 binding" NARROW []
synonym: "neurotrophin TRK receptor activity" RELATED []
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "neurotrophin TRKB receptor activity" RELATED []
synonym: "neurotrophin TRKC receptor activity" RELATED []
synonym: "neurotrophin-3 binding" NARROW []
synonym: "neurotrophin-4/5 binding" NARROW []
synonym: "NT 4/5 binding" NARROW []
synonym: "NT-3 binding" NARROW []
synonym: "NT-4 binding" NARROW []
synonym: "NT-4/5 binding" NARROW []
synonym: "NT-5 binding" NARROW []
synonym: "NT3 binding" NARROW []
synonym: "NT4 binding" NARROW []
synonym: "NT5 binding" NARROW []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0043122
name: regulation of canonical NF-kappaB signal transduction
namespace: biological_process
def: "Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]
synonym: "regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "regulation of I-kappaB kinase/NF-kappaB signaling" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0007249 ! canonical NF-kappaB signal transduction

[Term]
id: GO:0043123
name: positive regulation of canonical NF-kappaB signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade." [GOC:jl]
synonym: "activation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "positive regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "positive regulation of I-kappaB kinase/NF-kappaB signaling" EXACT []
synonym: "stimulation of I-kappaB kinase/NF-kappaB cascade" NARROW []
synonym: "up regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "up-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
is_a: GO:0043122 ! regulation of canonical NF-kappaB signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0007249 ! canonical NF-kappaB signal transduction

[Term]
id: GO:0043124
name: negative regulation of canonical NF-kappaB signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade." [GOC:jl]
synonym: "down regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "down-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "inhibition of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "negative regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "negative regulation of I-kappaB kinase/NF-kappaB signaling" EXACT []
is_a: GO:0043122 ! regulation of canonical NF-kappaB signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0007249 ! canonical NF-kappaB signal transduction

[Term]
id: GO:0043125
name: ErbB-3 class receptor binding
namespace: molecular_function
def: "Binding to the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl]
synonym: "HER3 receptor binding" EXACT []
synonym: "Neu/ErbB-2 receptor activity" RELATED []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0043126
name: obsolete regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of PI4K activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043127
name: obsolete negative regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "down-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "downregulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "inhibition of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "negative regulation of PI4K activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043128
name: obsolete positive regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "positive regulation of PI4K activity" EXACT []
synonym: "stimulation of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "up regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "up-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "upregulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043129
name: surfactant homeostasis
namespace: biological_process
alt_id: GO:0050828
def: "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid." [PMID:23708874, PMID:9751757]
synonym: "regulation of liquid surface tension" RELATED []
synonym: "regulation of surface tension of a liquid" RELATED []
synonym: "surfactant activity" RELATED []
is_a: GO:0140962 ! multicellular organismal-level chemical homeostasis

[Term]
id: GO:0043130
name: ubiquitin binding
namespace: molecular_function
def: "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]
xref: Reactome:R-HSA-1169404 "Transfer of ISG15 from E1 to E2 (UBCH8)"
xref: Reactome:R-HSA-205008 "Polyubiquitinated NRIF binds to p62 (Sequestosome)"
xref: Reactome:R-HSA-983152 "Transfer of ubiquitin from E1 to E2"
is_a: GO:0032182 ! ubiquitin-like protein binding

[Term]
id: GO:0043131
name: erythrocyte enucleation
namespace: biological_process
def: "The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hjd]
is_a: GO:0090601 ! enucleation
relationship: part_of GO:0043354 ! enucleate erythrocyte maturation

[Term]
id: GO:0043132
name: NAD transport
namespace: biological_process
def: "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl]
synonym: "NAD (oxidized) transport" EXACT []
synonym: "NAD (reduced) transport" EXACT []
synonym: "NADH transport" EXACT []
synonym: "nicotinamide adenine dinucleotide transport" EXACT []
synonym: "oxidized NAD transport" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT []
synonym: "reduced NAD transport" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT []
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0043133
name: hindgut contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046]
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0043134
name: regulation of hindgut contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0043135
name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+." [MetaCyc:RXN-10969, PMID:12370170]
synonym: "PRPP pyrophosphatase activity" EXACT []
xref: MetaCyc:RXN-10969
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0043136
name: glycerol-3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sn-glycerol 3-phosphate = glycerol + phosphate." [RHEA:66372]
xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN
xref: Reactome:R-HSA-8955794 "PGP:Mg2+ dimer hydrolyses 3PG to glycerol"
xref: RHEA:66372
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043137
name: DNA replication, removal of RNA primer
namespace: biological_process
def: "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238]
synonym: "Okazaki initiator RNA removal" EXACT []
is_a: GO:0006401 ! RNA catabolic process
relationship: part_of GO:0006260 ! DNA replication

[Term]
id: GO:0043138
name: 3'-5' DNA helicase activity
namespace: molecular_function
alt_id: GO:0043140
def: "Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]
synonym: "3' to 5' DNA helicase activity" EXACT []
synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT []
synonym: "ATP-dependent 3'-5' DNA helicase activity" EXACT []
xref: EC:5.6.2.4
xref: Reactome:R-HSA-167097 "HIV Promoter Opening: First Transition"
xref: Reactome:R-HSA-174438 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition"
xref: Reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition"
xref: Reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition"
xref: Reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript"
xref: Reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript"
xref: Reactome:R-HSA-9684118 "ERCC3-facilitated RNA Pol II backtracking in TC-NER"
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0043139
name: 5'-3' DNA helicase activity
namespace: molecular_function
alt_id: GO:0008722
alt_id: GO:0043141
def: "Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [EC:5.6.2.3, GOC:jl]
synonym: "5' to 3' DNA helicase activity" EXACT []
synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT []
synonym: "ATP-dependent 5'-3' DNA helicase activity" EXACT []
synonym: "DNA helicase IV activity" NARROW []
xref: EC:5.6.2.3
xref: Reactome:R-HSA-6782131 "ERCC2-facilitated RNA Pol II backtracking in TC-NER"
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0043143
name: regulation of translation by machinery localization
namespace: biological_process
def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl]
synonym: "establishment and maintenance of translational machinery localization" EXACT []
synonym: "establishment and maintenance of translational protein localization" EXACT []
synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah]
synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb]
synonym: "translational protein localization" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0008104 ! protein localization
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0043144
name: sno(s)RNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea)." [GOC:go_curators, GOC:krc, PMID:12773397]
subset: goslim_yeast
is_a: GO:0006396 ! RNA processing
is_a: GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:0043145
name: sno(s)RNA 3'-end cleavage
namespace: biological_process
def: "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397]
synonym: "sno(s)RNA 3' end cleavage" EXACT []
synonym: "snoRNA 3'-end cleavage" NARROW []
synonym: "sRNA 3'-end cleavage" NARROW []
is_a: GO:0031126 ! sno(s)RNA 3'-end processing

[Term]
id: GO:0043149
name: stress fiber assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity." [GOC:go_curators, GOC:mah, PMID:16651381]
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
synonym: "stress fibre biosynthesis" RELATED []
synonym: "stress fibre formation" RELATED []
is_a: GO:0030038 ! contractile actin filament bundle assembly
is_a: GO:0031032 ! actomyosin structure organization

[Term]
id: GO:0043150
name: DNA synthesis involved in double-strand break repair via homologous recombination
namespace: biological_process
def: "The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination." [GOC:go_curators]
synonym: "DNA synthesis during double-strand break repair via homologous recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
relationship: part_of GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0043151
name: DNA synthesis involved in double-strand break repair via single-strand annealing
namespace: biological_process
def: "The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing." [GOC:go_curators]
synonym: "DNA synthesis during double-strand break repair via single-strand annealing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0043152
name: induction of bacterial agglutination
namespace: biological_process
def: "Any process in which infecting bacteria are clumped together by a host organism." [GOC:jl]
is_a: GO:0019731 ! antibacterial humoral response

[Term]
id: GO:0043153
name: entrainment of circadian clock by photoperiod
namespace: biological_process
def: "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
synonym: "photoentrainment of circadian clock" EXACT [PMID:10217146]
is_a: GO:0009648 ! photoperiodism
is_a: GO:0009649 ! entrainment of circadian clock

[Term]
id: GO:0043154
name: obsolete negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
alt_id: GO:0001719
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "down regulation of caspase activity" EXACT []
synonym: "down-regulation of caspase activity" EXACT []
synonym: "downregulation of caspase activity" EXACT []
synonym: "inhibition of caspase activation" NARROW []
synonym: "inhibition of caspase activity" NARROW []
synonym: "negative regulation of caspase activation" EXACT []
synonym: "negative regulation of caspase activity" BROAD []
is_obsolete: true
replaced_by: GO:2000117

[Term]
id: GO:0043155
name: negative regulation of photosynthesis, light reaction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]
synonym: "down regulation of photosynthesis, light reaction" EXACT []
synonym: "down-regulation of photosynthesis, light reaction" EXACT []
synonym: "downregulation of photosynthesis, light reaction" EXACT []
synonym: "inhibition of photosynthesis, light reaction" NARROW []
is_a: GO:0042548 ! regulation of photosynthesis, light reaction
is_a: GO:1905156 ! negative regulation of photosynthesis
relationship: negatively_regulates GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0043156
name: obsolete chromatin remodeling in response to cation stress
namespace: biological_process
def: "OBSOLETE. Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0043157
name: response to cation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213]
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0043158
name: heterocyst development
namespace: biological_process
def: "The cellular developmental process by which a cell becomes a heterocyst, a cell that carries out nitrogen fixation. This process involves changes to the cell wall, expression of nitrogenase and other proteins involved in nitrogen fixation, and degradation of photosystem II, which produces oxygen. This process is known to occur in some cyanobacteria." [PMID:11121783, PMID:35744626]
synonym: "heterocyst cell differentiation" RELATED []
synonym: "heterocyst differentiation" RELATED []
synonym: "heterocyst formation" EXACT []
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0043159
name: acrosomal matrix
namespace: cellular_component
def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0001669 ! acrosomal vesicle
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0043160
name: acrosomal lumen
namespace: cellular_component
def: "The volume enclosed within the acrosome membrane." [GOC:go_curators]
is_a: GO:0034774 ! secretory granule lumen
is_a: GO:0043202 ! lysosomal lumen
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0043161
name: proteasome-mediated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
synonym: "proteasomal pathway" EXACT []
synonym: "proteasomal processing" RELATED []
synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT []
synonym: "proteasome pathway" RELATED []
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process
is_a: GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0043162
name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]
synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT []
synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT []
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0043163
name: cell envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl]
subset: goslim_pir
synonym: "cell envelope organisation" EXACT []
synonym: "cell envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0043164
name: Gram-negative-bacterium-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893]
synonym: "1-2nm peptidoglycan-based cell wall biogenesis" EXACT []
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0043165
name: Gram-negative-bacterium-type cell outer membrane assembly
namespace: biological_process
def: "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254]
synonym: "cell outer membrane biogenesis" RELATED [GOC:mah]
is_a: GO:0071709 ! membrane assembly
relationship: part_of GO:0043163 ! cell envelope organization

[Term]
id: GO:0043167
name: ion binding
namespace: molecular_function
def: "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
synonym: "atom binding" RELATED []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0043168
name: anion binding
namespace: molecular_function
def: "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]
is_a: GO:0043167 ! ion binding

[Term]
id: GO:0043169
name: cation binding
namespace: molecular_function
def: "Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]
is_a: GO:0043167 ! ion binding

[Term]
id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
alt_id: GO:0034960
alt_id: GO:0043283
alt_id: GO:0044259
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule metabolism" EXACT []
synonym: "multicellular organismal macromolecule metabolic process" NARROW []
synonym: "organismal macromolecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0043171
name: peptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl]
synonym: "peptide breakdown" EXACT []
synonym: "peptide catabolism" EXACT []
synonym: "peptide degradation" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0043172
name: obsolete ferredoxin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it refers to biosynthesis of a protein.
synonym: "ferredoxin anabolism" EXACT []
synonym: "ferredoxin biosynthesis" EXACT []
synonym: "ferredoxin formation" EXACT []
synonym: "ferredoxin synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0043173
name: nucleotide salvage
namespace: biological_process
def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl]
xref: Wikipedia:Nucleotide_salvage
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043174
name: nucleoside salvage
namespace: biological_process
def: "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl]
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043175
name: RNA polymerase core enzyme binding
namespace: molecular_function
def: "Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme." [GOC:jl, GOC:txnOH]
is_a: GO:0070063 ! RNA polymerase binding

[Term]
id: GO:0043176
name: amine binding
namespace: molecular_function
def: "Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group." [GOC:jl]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0043177
name: organic acid binding
namespace: molecular_function
def: "Binding to an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732]
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0043178
name: alcohol binding
namespace: molecular_function
def: "Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0043179
name: rhythmic excitation
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433]
is_a: GO:0060024 ! rhythmic synaptic transmission

[Term]
id: GO:0043180
name: rhythmic inhibition
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators]
is_a: GO:0060024 ! rhythmic synaptic transmission

[Term]
id: GO:0043181
name: vacuolar sequestering
namespace: biological_process
def: "The process of transporting a substance into, and confining within, a vacuole." [GOC:jl]
synonym: "retention in vacuole" EXACT []
synonym: "sequestering in vacuole" EXACT []
synonym: "sequestration in vacuole" EXACT []
synonym: "storage in vacuole" EXACT []
synonym: "vacuolar retention" EXACT []
synonym: "vacuolar sequestration" EXACT []
synonym: "vacuolar storage" EXACT []
is_a: GO:0051651 ! maintenance of location in cell

[Term]
id: GO:0043182
name: vacuolar sequestering of sodium ion
namespace: biological_process
def: "The process of transporting sodium ions into, and confining within, a vacuole." [GOC:jl]
synonym: "sequestering of sodium ion (Na+) in vacuole" EXACT []
synonym: "sequestration of sodium ion (Na+) in vacuole" EXACT []
synonym: "sodium ion (Na+) retention in vacuole" EXACT []
synonym: "sodium ion (Na+) storage in vacuole" EXACT []
synonym: "vacuolar sequestering of sodium ion (Na+)" EXACT []
synonym: "vacuolar sequestration of sodium ion (Na+)" EXACT []
synonym: "vacuolar sodium ion (Na+) retention" EXACT []
synonym: "vacuolar sodium ion (Na+) storage" EXACT []
is_a: GO:0043181 ! vacuolar sequestering
relationship: part_of GO:0006883 ! intracellular sodium ion homeostasis

[Term]
id: GO:0043183
name: vascular endothelial growth factor receptor 1 binding
namespace: molecular_function
def: "Binding to a vascular endothelial growth factor receptor 1." [GOC:st]
synonym: "Flt-1 binding" EXACT []
synonym: "VEGF receptor 1 binding" EXACT []
synonym: "VEGFR 1 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043184
name: vascular endothelial growth factor receptor 2 binding
namespace: molecular_function
def: "Binding to a vascular endothelial growth factor receptor 2." [GOC:st]
synonym: "Flk-1 binding" EXACT []
synonym: "KDR binding" BROAD []
synonym: "kinase domain region binding" EXACT []
synonym: "VEGF receptor 2 binding" EXACT []
synonym: "VEGFR 2 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043185
name: vascular endothelial growth factor receptor 3 binding
namespace: molecular_function
def: "Binding to a vascular endothelial growth factor receptor 3." [GOC:st]
synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT []
synonym: "VEGF receptor 3 binding" EXACT []
synonym: "VEGFR 3 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043186
name: P granule
namespace: cellular_component
alt_id: GO:0018994
def: "A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
synonym: "germline granule" BROAD []
synonym: "nuage" NARROW []
synonym: "polar granule" NARROW []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
relationship: part_of GO:0060293 ! germ plasm

[Term]
id: GO:0043188
name: cell septum edging
namespace: cellular_component
def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0043189
name: H4/H2A histone acetyltransferase complex
namespace: cellular_component
def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah, GOC:rb]
synonym: "H4/H2A HAT complex" EXACT []
is_a: GO:1902562 ! H4 histone acetyltransferase complex

[Term]
id: GO:0043190
name: ATP-binding cassette (ABC) transporter complex
namespace: cellular_component
alt_id: GO:0043191
alt_id: GO:0043192
def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "ABC-type efflux permease complex" NARROW []
synonym: "ABC-type efflux porter complex" NARROW []
synonym: "ABC-type uptake permease complex" NARROW []
synonym: "mating pheromone exporter" NARROW []
is_a: GO:0098533 ! ATPase dependent transmembrane transport complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0043194
name: axon initial segment
namespace: cellular_component
def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]
synonym: "initial segment" EXACT []
xref: NIF_Subcellular:sao256000789
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0043195
name: terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
synonym: "bouton" EXACT []
synonym: "presynaptic bouton" EXACT []
synonym: "synaptic bouton" EXACT [NIF_Subcellular:sao187426937]
synonym: "terminal button" EXACT []
xref: NIF_Subcellular:sao187426937
is_a: GO:0098793 ! presynapse
relationship: part_of GO:0043679 ! axon terminus

[Term]
id: GO:0043196
name: varicosity
namespace: cellular_component
def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0043197
name: dendritic spine
namespace: cellular_component
def: "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]
subset: goslim_synapse
synonym: "branched dendritic spine" NARROW [NIF_Subcellular:sao965204139]
synonym: "dendrite spine" EXACT []
synonym: "mushroom dendritic spine" NARROW [NIF_Subcellular:sao876577163]
synonym: "sessile dendritic spine" NARROW [NIF_Subcellular:sao1536532595]
synonym: "stubby dendritic spine" NARROW [NIF_Subcellular:sao317384566]
synonym: "thin dendritic spine" NARROW [NIF_Subcellular:sao1232858786]
xref: NIF_Subcellular:sao1799103720
xref: Wikipedia:Dendritic_spine
is_a: GO:0044309 ! neuron spine
is_a: GO:0098794 ! postsynapse
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043198
name: dendritic shaft
namespace: cellular_component
def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln]
synonym: "trunk" RELATED [NIF_Subcellular:sao1078172392]
xref: NIF_Subcellular:sao2034472720
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043199
name: sulfate binding
namespace: molecular_function
def: "Binding to sulfate, SO4(2-), a negatively charged small molecule." [GOC:mlg]
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043200
name: response to amino acid
namespace: biological_process
alt_id: GO:0010237
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg]
synonym: "response to amino acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical

[Term]
id: GO:0043201
name: response to L-leucine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus." [GOC:mlg]
synonym: "response to leucine" BROAD []
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0043202
name: lysosomal lumen
namespace: cellular_component
def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0043203
name: axon hillock
namespace: cellular_component
def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln]
xref: NIF_Subcellular:sao627227260
xref: Wikipedia:Axon_hillock
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030424 ! axon
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0043204
name: perikaryon
namespace: cellular_component
def: "The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl]
synonym: "cell soma cytoplasm" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0043207
name: response to external biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0043208
name: glycosphingolipid binding
namespace: molecular_function
def: "Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl]
is_a: GO:0046625 ! sphingolipid binding
is_a: GO:0051861 ! glycolipid binding

[Term]
id: GO:0043209
name: myelin sheath
namespace: cellular_component
def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin]
synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204]
synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730]
synonym: "Schwann cell myelin sheath" NARROW []
xref: FMA:62983
xref: NIF_Subcellular:sao593830697
xref: Wikipedia:Myelin
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0043210
name: alkanesulfonate binding
namespace: molecular_function
def: "Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:mlg]
is_a: GO:0043168 ! anion binding
is_a: GO:0043177 ! organic acid binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043211
name: ABC-type carbohydrate transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates and their derivatives across a membrane." [EC:7.5.2.-, GOC:mlg]
synonym: "ATP-dependent carbohydrate transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled carbohydrate transmembrane transporter activity" BROAD []
synonym: "carbohydrate ABC transporter" NARROW []
synonym: "carbohydrate-transporting ATPase activity" EXACT []
xref: EC:7.5.2.-
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0043212
name: carbohydrate-exporting ABC transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)." [GOC:mlg]
synonym: "carbohydrate-exporting ATPase activity" BROAD []
is_a: GO:0043211 ! ABC-type carbohydrate transporter activity

[Term]
id: GO:0043213
name: bacteriocin transport
namespace: biological_process
def: "The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg]
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0043214
name: ABC-type bacteriocin transporter activity
namespace: molecular_function
def: "Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate." [GOC:mlg, PMID:33040342]
synonym: "ABC-type bacteriocin transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled bacteriocin transmembrane transporter activity" RELATED []
synonym: "bacteriocin ABC transporter" EXACT []
is_a: GO:0008559 ! ABC-type xenobiotic transporter activity
is_a: GO:0022885 ! bacteriocin transmembrane transporter activity

[Term]
id: GO:0043215
name: daunorubicin transport
namespace: biological_process
def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0043216
name: obsolete ATPase-coupled daunorubicin transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg]
comment: This term was obsoleted because it represents a substrate-specific version of the general term GO:0008559 ATPase-coupled xenobiotic transmembrane transporter activity.
synonym: "ATP-dependent daunorubicin transmembrane transporter activity" EXACT []
synonym: "daunorubicin ABC transporter" NARROW []
synonym: "daunorubicin-transporting ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008559

[Term]
id: GO:0043217
name: myelin maintenance
namespace: biological_process
def: "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh]
synonym: "myelin sheath maintenance" EXACT []
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0042552 ! myelination

[Term]
id: GO:0043218
name: compact myelin
namespace: cellular_component
def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh, NIF_Subcellular:sao1123256993]
synonym: "oligodendrocyte compact myelin" NARROW [NIF_Subcellular:sao1186642361]
synonym: "Schwann cell compact myelin" NARROW []
xref: NIF_Subcellular:sao1123256993
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043219
name: lateral loop
namespace: cellular_component
def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh]
synonym: "oligodendrocyte paranodal termination" RELATED [NIF_Subcellular:sao1354781919]
synonym: "paranodal loop" RELATED [NIF_Subcellular:sao1354781919]
synonym: "Schwann cell paranodal termination" RELATED [NIF_Subcellular:sao1067215520]
xref: NIF_Subcellular:sao1067215520
xref: NIF_Subcellular:sao1354781919
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043220
name: Schmidt-Lanterman incisure
namespace: cellular_component
alt_id: GO:0044287
def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh]
synonym: "Schmidt-Lanterman cleft" EXACT []
xref: NIF_Subcellular:sao254777664
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043218 ! compact myelin

[Term]
id: GO:0043221
name: SMC family protein binding
namespace: molecular_function
def: "Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, GOC:vw, InterPro:IPR024704, PMID:9640531]
synonym: "structural maintenance of chromosomes family protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043223
name: cytoplasmic SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "cytoplasmic cullin complex" EXACT []
synonym: "cytoplasmic SCF complex" EXACT []
synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0043224
name: nuclear SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "nuclear cullin complex" EXACT []
synonym: "nuclear SCF complex" EXACT []
synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0043225
name: ATPase-coupled inorganic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in)." [GOC:mlg]
synonym: "anion ABC transporter" NARROW []
synonym: "anion transmembrane-transporting ATPase activity" RELATED []
synonym: "anion-transporting ATPase activity" EXACT []
synonym: "ATP-dependent anion transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled anion transmembrane transporter activity" EXACT []
xref: Reactome:R-HSA-1454916 "The ABCC family mediates organic anion transport"
xref: Reactome:R-HSA-5690340 "Defective ABCC6 does not transport organic anion from cytosol to extracellular region"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0043226
name: organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
xref: NIF_Subcellular:sao1539965131
xref: Wikipedia:Organelle
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0043227
name: membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao414196390
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043228
name: membraneless organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_mouse
synonym: "biological condensate" RELATED []
synonym: "membrane-less organelle" EXACT []
synonym: "non-membrane-bounded organelle" EXACT []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_pir
is_a: GO:0043226 ! organelle
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]
subset: goslim_pir
is_a: GO:0043226 ! organelle
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
synonym: "intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043232
name: intracellular membraneless organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_pir
synonym: "intracellular non-membrane-bounded organelle" EXACT []
synonym: "intracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! membraneless organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043233
name: organelle lumen
namespace: cellular_component
def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]
subset: goslim_mouse
is_a: GO:0031974 ! membrane-enclosed lumen
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0043235
name: receptor complex
namespace: cellular_component
def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0043236
name: laminin binding
namespace: molecular_function
alt_id: GO:0043238
alt_id: GO:0043239
def: "Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]
synonym: "laminin-2 binding" NARROW []
synonym: "laminin-4 binding" NARROW []
is_a: GO:0005515 ! protein binding
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0043237
name: laminin-1 binding
namespace: molecular_function
def: "Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators]
synonym: "laminin-111 binding" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043236 ! laminin binding

[Term]
id: GO:0043240
name: Fanconi anaemia nuclear complex
namespace: cellular_component
def: "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]
synonym: "FA complex" EXACT []
synonym: "FA core complex" EXACT []
synonym: "FA nuclear complex" EXACT []
synonym: "Fanconi anaemia complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0043242
name: negative regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "down regulation of protein complex disassembly" EXACT []
synonym: "down-regulation of protein complex disassembly" EXACT []
synonym: "downregulation of protein complex disassembly" EXACT []
synonym: "inhibition of protein complex disassembly" NARROW []
synonym: "negative regulation of protein complex disassembly" RELATED []
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0043243
name: positive regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "activation of protein complex disassembly" NARROW []
synonym: "positive regulation of protein complex disassembly" RELATED []
synonym: "stimulation of protein complex disassembly" NARROW []
synonym: "up regulation of protein complex disassembly" EXACT []
synonym: "up-regulation of protein complex disassembly" EXACT []
synonym: "upregulation of protein complex disassembly" EXACT []
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0043244
name: regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "regulation of protein complex disassembly" RELATED []
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0043245
name: extraorganismal space
namespace: cellular_component
def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0043246
name: megasome
namespace: cellular_component
def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [PMID:11206117, PMID:1999020]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0043247
name: telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that occur in response to the presence of critically short or damaged telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784]
synonym: "DNA damage response, telomere maintenance" EXACT []
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0006974 ! DNA damage response

[Term]
id: GO:0043248
name: proteasome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]
synonym: "26S proteasome assembly" NARROW []
synonym: "proteasome complex assembly" EXACT []
synonym: "proteasome maturation" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0043249
name: erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl]
synonym: "RBC maturation" EXACT [CL:0000232]
synonym: "red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048821 ! erythrocyte development

[Term]
id: GO:0043250
name: sodium-dependent organic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators]
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0043251
name: sodium-dependent organic anion transport
namespace: biological_process
def: "The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0043252
name: sodium-independent organic anion transport
namespace: biological_process
def: "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0043253
name: chloroplast ribosome
namespace: cellular_component
def: "A ribosome contained within a chloroplast." [GOC:ecd]
is_a: GO:0009547 ! plastid ribosome
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0043254
name: regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]
synonym: "regulation of protein complex assembly" RELATED []
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0043255
name: regulation of carbohydrate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]
synonym: "regulation of carbohydrate anabolism" EXACT []
synonym: "regulation of carbohydrate biosynthesis" EXACT []
synonym: "regulation of carbohydrate formation" EXACT []
synonym: "regulation of carbohydrate synthesis" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0043256
name: laminin complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, PMID:10842354]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0043257
name: laminin-8 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-411 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043258
name: laminin-9 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-421 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043259
name: laminin-10 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-511 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043260
name: laminin-11 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-521 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043261
name: laminin-12 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354]
synonym: "laminin-213 complex" EXACT [GOC:dph, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043262
name: ADP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+." [PMID:1470606, RHEA:61436]
synonym: "adenosine diphosphatase activity" RELATED []
synonym: "adenosine-diphosphatase activity" EXACT []
synonym: "ADP diphosphatase activity" BROAD []
synonym: "ADPase" BROAD []
synonym: "ADPase activity" RELATED []
synonym: "ATP diphosphohydrolase activity" RELATED []
synonym: "ATP-diphosphatase activity" RELATED []
xref: MetaCyc:RXN-10862
xref: RHEA:61436
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0043263
name: cellulosome
namespace: cellular_component
alt_id: GO:1990296
def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609, PMID:15197390, PMID:20373916]
synonym: "scaffoldin complex" NARROW []
xref: Wikipedia:Cellulosome
is_a: GO:0043264 ! extracellular membraneless organelle

[Term]
id: GO:0043264
name: extracellular membraneless organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl]
synonym: "extracellular non-membrane-bounded organelle" EXACT []
synonym: "extracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! membraneless organelle
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0043265
name: obsolete ectoplasm
namespace: cellular_component
def: "OBSOLETE. Granule free cytoplasm, lying immediately below the plasma membrane." [GOC:curators, PMID:12211103]
comment: The reason for obsoletion is that this term was added in error.
is_obsolete: true
replaced_by: GO:0005938

[Term]
id: GO:0043266
name: regulation of potassium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "regulation of K+ conductance" NARROW []
synonym: "regulation of K+ transport" EXACT []
synonym: "regulation of potassium conductance" NARROW []
synonym: "regulation of potassium ion conductance" NARROW []
synonym: "regulation of potassium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043267
name: negative regulation of potassium ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of potassium ion transport" EXACT []
synonym: "down-regulation of potassium ion transport" EXACT []
synonym: "downregulation of potassium ion transport" EXACT []
synonym: "inhibition of potassium ion transport" NARROW []
synonym: "negative regulation of K+ transport" EXACT []
synonym: "negative regulation of potassium ion conductance" NARROW []
synonym: "negative regulation of potassium transport" EXACT []
synonym: "regulation of K+ conductance" NARROW []
synonym: "regulation of potassium conductance" NARROW []
synonym: "transmembrane conductance regulator activity" RELATED []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
relationship: negatively_regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043268
name: positive regulation of potassium ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "activation of potassium ion transport" NARROW []
synonym: "positive regulation of K+ conductance" NARROW []
synonym: "positive regulation of K+ transport" EXACT []
synonym: "positive regulation of potassium conductance" NARROW []
synonym: "positive regulation of potassium ion conductance" NARROW []
synonym: "positive regulation of potassium transport" EXACT []
synonym: "stimulation of potassium ion transport" NARROW []
synonym: "up regulation of potassium ion transport" EXACT []
synonym: "up-regulation of potassium ion transport" EXACT []
synonym: "upregulation of potassium ion transport" EXACT []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
relationship: positively_regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043269
name: regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "regulation of ion transport" BROAD []
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0043270
name: positive regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "activation of ion transport" NARROW []
synonym: "stimulation of ion transport" NARROW []
synonym: "up regulation of ion transport" EXACT []
synonym: "up-regulation of ion transport" EXACT []
synonym: "upregulation of ion transport" EXACT []
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0043271
name: negative regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of ion transport" EXACT []
synonym: "down-regulation of ion transport" EXACT []
synonym: "downregulation of ion transport" EXACT []
synonym: "inhibition of ion transport" NARROW []
synonym: "negative regulation of ion transport" BROAD []
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0043272
name: ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl]
synonym: "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance" RELATED []
synonym: "ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb]
synonym: "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance" RELATED []
synonym: "ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance" RELATED []
is_a: GO:0009693 ! ethylene biosynthetic process
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0043273
name: CTPase activity
namespace: molecular_function
alt_id: GO:0061747
alt_id: GO:0061748
def: "Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction." [RHEA:29387]
synonym: "CTPase activity, coupled" RELATED []
synonym: "cytidine triphosphatase activity" EXACT []
synonym: "single-stranded DNA-dependent CTPase activity" NARROW []
xref: RHEA:29387
is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity

[Term]
id: GO:0043274
name: phospholipase binding
namespace: molecular_function
def: "Binding to a phospholipase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0043275
name: obsolete glutamate carboxypeptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [GOC:jl]
comment: This term was made obsolete because it represents a gene product.
synonym: "acetylaspartylglutamate dipeptidase activity" EXACT []
synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "folylpolyglutamate hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "glutamate carboxypeptidase II activity" EXACT []
synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "mGCP" RELATED [EC:3.4.17.21]
synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "N-acetylated alpha-linked acidic dipeptidase activity" RELATED [EC:3.4.17.21]
synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" RELATED [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" RELATED [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" RELATED [EC:3.4.17.21]
synonym: "NAALA dipeptidase activity" RELATED [EC:3.4.17.21]
synonym: "NAALADase activity" RELATED [EC:3.4.17.21]
synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "PSM antigen" RELATED [EC:3.4.17.21]
synonym: "PSMA" RELATED [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" RELATED [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "pteroylpolygammaglutamyl hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "pteroylpolyglutamate hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "pteroylpolyglutamic acid hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0043276
name: anoikis
namespace: biological_process
def: "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, PMID:37667281]
synonym: "detachment induced cell death" EXACT []
synonym: "suspension induced apoptosis" EXACT []
xref: Wikipedia:Anoikis
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0043277
name: apoptotic cell clearance
namespace: biological_process
def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]
comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells.
synonym: "apoptotic cell removal" EXACT []
synonym: "efferocytosis" EXACT [PMID:17548650]
synonym: "programmed cell clearance" EXACT []
is_a: GO:0006909 ! phagocytosis

[Term]
id: GO:0043278
name: response to morphine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:ef, GOC:jl]
is_a: GO:0014072 ! response to isoquinoline alkaloid

[Term]
id: GO:0043279
name: response to alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0043280
name: obsolete positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activation of caspase activity" NARROW []
synonym: "positive regulation of caspase activity" BROAD []
synonym: "stimulation of caspase activity" NARROW []
synonym: "up regulation of caspase activity" EXACT []
synonym: "up-regulation of caspase activity" EXACT []
synonym: "upregulation of caspase activity" EXACT []
is_obsolete: true
replaced_by: GO:2001056

[Term]
id: GO:0043281
name: obsolete regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
alt_id: GO:0043026
def: "OBSOLETE. Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis." [GOC:jl, GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "regulation of caspase activation" NARROW []
synonym: "regulation of caspase activity" BROAD []
is_obsolete: true
replaced_by: GO:2000116

[Term]
id: GO:0043282
name: chordate pharyngeal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development
relationship: part_of GO:0160093 ! chordate pharynx development

[Term]
id: GO:0043286
name: regulation of poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]
synonym: "regulation of PHA" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) anabolism" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) biosynthesis" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) formation" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process

[Term]
id: GO:0043287
name: poly(3-hydroxyalkanoate) binding
namespace: molecular_function
def: "Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]
synonym: "PHA binding" EXACT []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0043288
name: apocarotenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl]
synonym: "apo carotenoid metabolic process" EXACT []
synonym: "apocarotenoid metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0043289
name: apocarotenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, PMID:27485225]
synonym: "apo carotenoid biosynthetic process" EXACT []
synonym: "apocarotenoid anabolism" EXACT []
synonym: "apocarotenoid biosynthesis" EXACT []
synonym: "apocarotenoid formation" EXACT []
synonym: "apocarotenoid synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0043290
name: apocarotenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, PMID:33721905, PMID:34956282]
synonym: "apo carotenoid catabolic process" EXACT []
synonym: "apocarotenoid breakdown" EXACT []
synonym: "apocarotenoid catabolism" EXACT []
synonym: "apocarotenoid degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0043291
name: RAVE complex
namespace: cellular_component
def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802]
synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0043292
name: contractile muscle fiber
namespace: cellular_component
def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]
synonym: "contractile fibre" EXACT []
is_a: GO:0043232 ! intracellular membraneless organelle
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0043293
name: apoptosome
namespace: cellular_component
def: "A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [GOC:mtg_apoptosis, PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137]
xref: Wikipedia:Apoptosome
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0043294
name: mitochondrial glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031027 ! glutamate synthase complex (NADH)
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0043295
name: glutathione binding
namespace: molecular_function
def: "Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]
is_a: GO:0043168 ! anion binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:1900750 ! oligopeptide binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043296
name: apical junction complex
namespace: cellular_component
def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]
synonym: "apical cell junction complex" EXACT [GOC:mah]
synonym: "apical junction" EXACT []
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0043297
name: apical junction assembly
namespace: biological_process
def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]
synonym: "apical junction complex assembly" EXACT [GOC:mah]
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0043299
name: leukocyte degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "immune cell degranulation" EXACT []
synonym: "immune cell granule exocytosis" EXACT []
synonym: "leucocyte degranulation" EXACT []
synonym: "leukocyte granule exocytosis" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0045055 ! regulated exocytosis
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0043300
name: regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149]
synonym: "regulation of immune cell degranulation" EXACT []
synonym: "regulation of immune cell granule exocytosis" EXACT []
synonym: "regulation of leucocyte degranulation" EXACT []
synonym: "regulation of leukocyte granule exocytosis" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:1903305 ! regulation of regulated secretory pathway
relationship: regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043301
name: negative regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149]
synonym: "down regulation of leukocyte degranulation" EXACT []
synonym: "down-regulation of leukocyte degranulation" EXACT []
synonym: "downregulation of leukocyte degranulation" EXACT []
synonym: "inhibition of leukocyte degranulation" NARROW []
synonym: "negative regulation of immune cell degranulation" EXACT []
synonym: "negative regulation of leucocyte degranulation" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:1903306 ! negative regulation of regulated secretory pathway
relationship: negatively_regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043302
name: positive regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149]
synonym: "activation of leukocyte degranulation" NARROW []
synonym: "positive regulation of immune cell degranulation" EXACT []
synonym: "positive regulation of leucocyte degranulation" EXACT []
synonym: "stimulation of leukocyte degranulation" NARROW []
synonym: "up regulation of leukocyte degranulation" EXACT []
synonym: "up-regulation of leukocyte degranulation" EXACT []
synonym: "upregulation of leukocyte degranulation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:1903307 ! positive regulation of regulated secretory pathway
relationship: positively_regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043303
name: mast cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149]
synonym: "mast cell granule exocytosis" EXACT []
is_a: GO:0032418 ! lysosome localization
is_a: GO:0043299 ! leukocyte degranulation
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0002279 ! mast cell activation involved in immune response
relationship: part_of GO:0002448 ! mast cell mediated immunity

[Term]
id: GO:0043304
name: regulation of mast cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149]
synonym: "regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
relationship: regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043305
name: negative regulation of mast cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149]
synonym: "down regulation of mast cell degranulation" EXACT []
synonym: "down-regulation of mast cell degranulation" EXACT []
synonym: "downregulation of mast cell degranulation" EXACT []
synonym: "inhibition of mast cell degranulation" NARROW []
synonym: "negative regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
relationship: negatively_regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043306
name: positive regulation of mast cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149]
synonym: "activation of mast cell degranulation" NARROW []
synonym: "positive regulation of mast cell granule exocytosis" EXACT []
synonym: "stimulation of mast cell degranulation" NARROW []
synonym: "up regulation of mast cell degranulation" EXACT []
synonym: "up-regulation of mast cell degranulation" EXACT []
synonym: "upregulation of mast cell degranulation" EXACT []
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
relationship: positively_regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043307
name: eosinophil activation
namespace: biological_process
def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149]
is_a: GO:0036230 ! granulocyte activation

[Term]
id: GO:0043308
name: eosinophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149]
synonym: "eosinophil granule exocytosis" EXACT []
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002278 ! eosinophil activation involved in immune response
relationship: part_of GO:0002447 ! eosinophil mediated immunity

[Term]
id: GO:0043309
name: regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149]
synonym: "regulation of eosinophil granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043310
name: negative regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149]
synonym: "down regulation of eosinophil degranulation" EXACT []
synonym: "down-regulation of eosinophil degranulation" EXACT []
synonym: "downregulation of eosinophil degranulation" EXACT []
synonym: "inhibition of eosinophil degranulation" NARROW []
synonym: "negative regulation of eosinophil granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043311
name: positive regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149]
synonym: "activation of eosinophil degranulation" NARROW []
synonym: "positive regulation of eosinophil granule exocytosis" EXACT []
synonym: "stimulation of eosinophil degranulation" NARROW []
synonym: "up regulation of eosinophil degranulation" EXACT []
synonym: "up-regulation of eosinophil degranulation" EXACT []
synonym: "upregulation of eosinophil degranulation" EXACT []
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043312
name: neutrophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149]
synonym: "heterophil degranulation" RELATED []
synonym: "neutrophil granule exocytosis" EXACT []
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002283 ! neutrophil activation involved in immune response
relationship: part_of GO:0002446 ! neutrophil mediated immunity

[Term]
id: GO:0043313
name: regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149]
synonym: "regulation of neutrophil granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043314
name: negative regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149]
synonym: "down regulation of neutrophil degranulation" EXACT []
synonym: "down-regulation of neutrophil degranulation" EXACT []
synonym: "downregulation of neutrophil degranulation" EXACT []
synonym: "inhibition of neutrophil degranulation" NARROW []
synonym: "negative regulation of neutrophil granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043315
name: positive regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149]
synonym: "activation of neutrophil degranulation" NARROW []
synonym: "positive regulation of neutrophil granule exocytosis" EXACT []
synonym: "stimulation of neutrophil degranulation" NARROW []
synonym: "up regulation of neutrophil degranulation" EXACT []
synonym: "up-regulation of neutrophil degranulation" EXACT []
synonym: "upregulation of neutrophil degranulation" EXACT []
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043316
name: cytotoxic T cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149]
synonym: "cytotoxic T cell granule exocytosis" EXACT []
synonym: "cytotoxic T lymphocyte degranulation" EXACT []
synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "cytotoxic T-cell degranulation" EXACT []
synonym: "cytotoxic T-cell granule exocytosis" EXACT []
synonym: "cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0001913 ! T cell mediated cytotoxicity
relationship: part_of GO:0002286 ! T cell activation involved in immune response

[Term]
id: GO:0043317
name: regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149]
synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
relationship: regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043318
name: negative regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149]
synonym: "down regulation of cytotoxic T cell degranulation" EXACT []
synonym: "down-regulation of cytotoxic T cell degranulation" EXACT []
synonym: "downregulation of cytotoxic T cell degranulation" EXACT []
synonym: "inhibition of cytotoxic T cell degranulation" NARROW []
synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043319
name: positive regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149]
synonym: "activation of cytotoxic T cell degranulation" NARROW []
synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
synonym: "stimulation of cytotoxic T cell degranulation" NARROW []
synonym: "up regulation of cytotoxic T cell degranulation" EXACT []
synonym: "up-regulation of cytotoxic T cell degranulation" EXACT []
synonym: "upregulation of cytotoxic T cell degranulation" EXACT []
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043320
name: natural killer cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149]
synonym: "natural killer cell granule exocytosis" EXACT []
synonym: "NK cell degranulation" EXACT []
synonym: "NK cell granule exocytosis" EXACT []
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002323 ! natural killer cell activation involved in immune response
relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0043321
name: regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149]
synonym: "regulation of natural killer cell granule exocytosis" EXACT []
synonym: "regulation of NK cell degranulation" EXACT []
synonym: "regulation of NK cell granule exocytosis" EXACT []
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
relationship: regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043322
name: negative regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149]
synonym: "down regulation of natural killer cell degranulation" EXACT []
synonym: "down-regulation of natural killer cell degranulation" EXACT []
synonym: "downregulation of natural killer cell degranulation" EXACT []
synonym: "inhibition of natural killer cell degranulation" NARROW []
synonym: "negative regulation of natural killer cell granule exocytosis" EXACT []
synonym: "negative regulation of NK cell degranulation" EXACT []
synonym: "negative regulation of NK cell granule exocytosis" EXACT []
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity
relationship: negatively_regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043323
name: positive regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149]
synonym: "activation of natural killer cell degranulation" NARROW []
synonym: "positive regulation of natural killer cell granule exocytosis" EXACT []
synonym: "positive regulation of NK cell degranulation" EXACT []
synonym: "positive regulation of NK cell granule exocytosis" EXACT []
synonym: "stimulation of natural killer cell degranulation" NARROW []
synonym: "up regulation of natural killer cell degranulation" EXACT []
synonym: "up-regulation of natural killer cell degranulation" EXACT []
synonym: "upregulation of natural killer cell degranulation" EXACT []
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
relationship: positively_regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043324
name: pigment metabolic process involved in developmental pigmentation
namespace: biological_process
def: "The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism." [GOC:jl, ISBN:0198506732]
synonym: "pigment metabolic process during developmental pigmentation" RELATED [GOC:dph, GOC:tb]
synonym: "pigment metabolism during developmental pigmentation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043474 ! pigment metabolic process involved in pigmentation
relationship: part_of GO:0048066 ! developmental pigmentation

[Term]
id: GO:0043325
name: phosphatidylinositol-3,4-bisphosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [GOC:bf, GOC:go_curators]
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0043326
name: chemotaxis to folate
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators]
is_a: GO:0006935 ! chemotaxis
is_a: GO:0051593 ! response to folic acid

[Term]
id: GO:0043327
name: chemotaxis to cAMP
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators]
synonym: "chemotaxis to 3',5' cAMP" EXACT []
synonym: "chemotaxis to 3',5'-cAMP" EXACT []
synonym: "chemotaxis to adenosine 3',5'-cyclophosphate" EXACT []
synonym: "chemotaxis to cyclic AMP" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0043328
name: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343]
synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb]
synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway
is_a: GO:0072666 ! establishment of protein localization to vacuole
relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

[Term]
id: GO:0043329
name: obsolete protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "OBSOLETE. The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl]
comment: The reason for obsoleting is that the term is not clearly defined, ie the membrane to which proteins are being targeted is not specified.
synonym: "protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb]
synonym: "protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0043330
name: response to exogenous dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators]
comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'.
synonym: "response to exogenous double-stranded RNA" EXACT []
synonym: "response to viral dsRNA" NARROW []
is_a: GO:0043331 ! response to dsRNA

[Term]
id: GO:0043331
name: response to dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl]
synonym: "response to double-stranded RNA" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0043332
name: mating projection tip
namespace: cellular_component
def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc]
synonym: "conjugation tube tip" NARROW []
synonym: "shmoo tip" NARROW []
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0051286 ! cell tip
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0043333
name: obsolete 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity
namespace: molecular_function
alt_id: GO:0102005
def: "OBSOLETE. Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008425

[Term]
id: GO:0043334
name: obsolete 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008425

[Term]
id: GO:0043335
name: protein unfolding
namespace: biological_process
def: "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0043336
name: site-specific telomere resolvase activity
namespace: molecular_function
def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598]
comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres.
synonym: "ResT" NARROW []
synonym: "TelN" NARROW []
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0043337
name: cardiolipin synthase (CMP-forming)
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol." [GOC:jl]
synonym: "cardiolipin synthase" BROAD []
synonym: "cardiolipin synthetase" BROAD []
synonym: "CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity" EXACT []
xref: EC:2.7.8.41
xref: MetaCyc:RXN-8141
xref: Reactome:R-HSA-1483063 "PG and CDP-DAG are converted to CL by CRLS1"
xref: RHEA:32931
is_a: GO:0030572 ! phosphatidyltransferase activity

[Term]
id: GO:0043338
name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477, RHEA:25690]
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD []
xref: EC:2.7.7.67
xref: RHEA:25690
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0043353
name: enucleate erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators]
synonym: "enucleate RBC differentiation" EXACT [CL:0000232]
synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0043354
name: enucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators]
synonym: "enucleate RBC maturation" EXACT [CL:0000232]
synonym: "enucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
relationship: part_of GO:0048822 ! enucleate erythrocyte development

[Term]
id: GO:0043362
name: nucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl]
synonym: "nucleate RBC maturation" EXACT [CL:0000232]
synonym: "nucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
relationship: part_of GO:0048823 ! nucleate erythrocyte development

[Term]
id: GO:0043363
name: nucleate erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl]
synonym: "nucleate RBC differentiation" EXACT [CL:0000232]
synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0043364
name: glycyl-radical enzyme activating activity
namespace: molecular_function
def: "Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)." [GOC:jl, PMID:24486374]
subset: goslim_pir
synonym: "catalysis of free radical formation" BROAD []
xref: EC:1.97.1.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043365
name: [formate-C-acetyltransferase]-activating enzyme activity
namespace: molecular_function
alt_id: GO:0008862
def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl, PMID:18307109]
synonym: "[pyruvate formate-lyase]-activating enzyme activity" RELATED [EC:1.97.1.4]
synonym: "formate acetyltransferase activating enzyme activity" RELATED [EC:1.97.1.4]
synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" RELATED [EC:1.97.1.4]
synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" RELATED [EC:1.97.1.4]
synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4]
synonym: "PFL activase activity" RELATED [EC:1.97.1.4]
synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" RELATED [EC:1.97.1.4]
synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4]
xref: EC:1.97.1.4
xref: MetaCyc:TDCEACT-RXN
xref: RHEA:19225
is_a: GO:0043364 ! glycyl-radical enzyme activating activity

[Term]
id: GO:0043366
name: beta selection
namespace: biological_process
def: "The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149, PMID:12220932]
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043367
name: CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf]
synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043368
name: positive T cell selection
namespace: biological_process
def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722]
synonym: "positive T lymphocyte selection" EXACT []
synonym: "positive T-cell selection" EXACT []
synonym: "positive T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection

[Term]
id: GO:0043369
name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149]
synonym: "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive/CD8-positive, alpha-beta T cell lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0043368 ! positive T cell selection

[Term]
id: GO:0043370
name: regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf]
synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
relationship: regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043371
name: negative regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation
relationship: negatively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043372
name: positive regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "positive regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf]
synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
relationship: positively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043373
name: CD4-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149]
synonym: "CD4-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002363 ! alpha-beta T cell lineage commitment
is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043374
name: CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043375
name: CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149]
synonym: "CD8-positive, alpha-beta T cell fate commitment" EXACT []
synonym: "CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD8-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002363 ! alpha-beta T cell lineage commitment
is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043376
name: regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
relationship: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043377
name: negative regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation
relationship: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043378
name: positive regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation
relationship: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043379
name: memory T cell differentiation
namespace: biological_process
def: "The process in which a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "memory T cell development" RELATED [GOC:add]
synonym: "memory T lymphocyte differentiation" EXACT []
synonym: "memory T-cell differentiation" EXACT []
synonym: "memory T-lymphocyte differentiation" EXACT []
is_a: GO:0002292 ! T cell differentiation involved in immune response
is_a: GO:0090715 ! immunological memory formation process

[Term]
id: GO:0043380
name: regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of memory T cell development" RELATED [GOC:add]
synonym: "regulation of memory T lymphocyte differentiation" EXACT []
synonym: "regulation of memory T-cell differentiation" EXACT []
synonym: "regulation of memory T-lymphocyte differentiation" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043381
name: negative regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of memory T cell differentiation" EXACT []
synonym: "down-regulation of memory T cell differentiation" EXACT []
synonym: "downregulation of memory T cell differentiation" EXACT []
synonym: "inhibition of memory T cell differentiation" NARROW []
synonym: "negative regulation of memory T cell development" RELATED [GOC:add]
synonym: "negative regulation of memory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of memory T-cell differentiation" EXACT []
synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0043380 ! regulation of memory T cell differentiation
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043382
name: positive regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of memory T cell differentiation" NARROW []
synonym: "positive regulation of memory T cell development" RELATED [GOC:add]
synonym: "positive regulation of memory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of memory T-cell differentiation" EXACT []
synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT []
synonym: "stimulation of memory T cell differentiation" NARROW []
synonym: "up regulation of memory T cell differentiation" EXACT []
synonym: "up-regulation of memory T cell differentiation" EXACT []
synonym: "upregulation of memory T cell differentiation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043380 ! regulation of memory T cell differentiation
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043383
name: negative T cell selection
namespace: biological_process
def: "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722]
synonym: "negative T lymphocyte selection" EXACT []
synonym: "negative T-cell selection" EXACT []
synonym: "negative T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection

[Term]
id: GO:0043384
name: pre-T cell receptor complex
namespace: cellular_component
def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932]
synonym: "pre-T lymphocyte receptor complex" EXACT []
synonym: "pre-T-cell receptor complex" EXACT []
synonym: "pre-T-lymphocyte receptor complex" EXACT []
synonym: "pre-TCR complex" EXACT []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0043385
name: mycotoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl]
synonym: "mycotoxin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0043386
name: mycotoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl]
synonym: "mycotoxin anabolism" EXACT []
synonym: "mycotoxin biosynthesis" EXACT []
synonym: "mycotoxin formation" EXACT []
synonym: "mycotoxin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0043387
name: mycotoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl]
synonym: "mycotoxin breakdown" EXACT []
synonym: "mycotoxin catabolism" EXACT []
synonym: "mycotoxin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0043388
name: positive regulation of DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "activation of DNA binding" NARROW []
synonym: "stimulation of DNA binding" NARROW []
synonym: "up regulation of DNA binding" EXACT []
synonym: "up-regulation of DNA binding" EXACT []
synonym: "upregulation of DNA binding" EXACT []
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:0043392
name: negative regulation of DNA binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "down regulation of DNA binding" EXACT []
synonym: "down-regulation of DNA binding" EXACT []
synonym: "downregulation of DNA binding" EXACT []
synonym: "inhibition of DNA binding" NARROW []
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:0043393
name: regulation of protein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0043394
name: proteoglycan binding
namespace: molecular_function
def: "Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732]
is_a: GO:0005515 ! protein binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0043395
name: heparan sulfate proteoglycan binding
namespace: molecular_function
def: "Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732]
synonym: "heparin proteoglycan binding" RELATED []
is_a: GO:0043394 ! proteoglycan binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043396
name: corticotropin-releasing hormone secretion
namespace: biological_process
def: "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914]
synonym: "corticotropin-releasing factor secretion" EXACT []
synonym: "CRF secretion" EXACT []
synonym: "CRH secretion" EXACT []
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0043397
name: regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914]
synonym: "regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "regulation of CRF secretion" EXACT []
synonym: "regulation of CRH secretion" EXACT []
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0043398
name: HLH domain binding
namespace: molecular_function
def: "Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0043399
name: tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:22030622, PMID:7954819]
synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT []
synonym: "tRNA A64-2'-O-ribosylphosphate transferase activity" EXACT []
is_a: GO:0016763 ! pentosyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0043400
name: cortisol secretion
namespace: biological_process
def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914]
synonym: "hydrocortisone secretion" EXACT [CHEBI:17650]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035933 ! glucocorticoid secretion

[Term]
id: GO:0043401
name: steroid hormone receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]
synonym: "steroid hormone mediated signalling" EXACT []
synonym: "steroid hormone-mediated signaling pathway" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0043402
name: glucocorticoid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347]
synonym: "glucocorticoid mediated signalling" EXACT []
is_a: GO:0043401 ! steroid hormone receptor signaling pathway
relationship: part_of GO:0071385 ! cellular response to glucocorticoid stimulus

[Term]
id: GO:0043403
name: skeletal muscle tissue regeneration
namespace: biological_process
def: "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119]
synonym: "myofiber turnover" RELATED []
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0043404
name: corticotropin-releasing hormone receptor activity
namespace: molecular_function
alt_id: GO:0031636
def: "Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity." [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857]
synonym: "adrenocorticotropin-releasing hormone receptor activity" EXACT []
synonym: "corticotropin-releasing factor receptor activity" EXACT [GOC:bf]
synonym: "CRF receptor activity" EXACT [GOC:bf]
synonym: "CRH receptor activity" EXACT [GOC:bf]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0043405
name: regulation of MAP kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "Regulation of MAPK activity" EXACT [GOC:dph]
synonym: "regulation of mitogen activated protein kinase activity" EXACT []
synonym: "regulation of mitogen-activated protein kinase activity" EXACT []
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:0043406
name: positive regulation of MAP kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of mitogen activated protein kinase activity" EXACT []
synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT []
synonym: "stimulation of MAPK activity" NARROW []
synonym: "up regulation of MAPK activity" EXACT []
synonym: "up-regulation of MAPK activity" EXACT []
synonym: "upregulation of MAPK activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity

[Term]
id: GO:0043407
name: negative regulation of MAP kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of MAPK activity" EXACT []
synonym: "down-regulation of MAPK activity" EXACT []
synonym: "downregulation of MAPK activity" EXACT []
synonym: "inhibition of MAPK activity" NARROW []
synonym: "negative regulation of mitogen activated protein kinase activity" EXACT []
synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity

[Term]
id: GO:0043408
name: regulation of MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]
synonym: "regulation of MAP kinase cascade" EXACT [GOC:signaling]
synonym: "regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "regulation of MAPKKK cascade" EXACT [GOC:signaling]
synonym: "regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0000165 ! MAPK cascade

[Term]
id: GO:0043409
name: negative regulation of MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]
synonym: "down regulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "down regulation of MAPKKK cascade" EXACT []
synonym: "down-regulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "down-regulation of MAPKKK cascade" EXACT []
synonym: "downregulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "downregulation of MAPKKK cascade" EXACT []
synonym: "inhibition of MAPK cascade" NARROW [GOC:signaling]
synonym: "inhibition of MAPKKK cascade" NARROW []
synonym: "negative regulation of MAP kinase cascade" EXACT [GOC:signaling]
synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "negative regulation of MAPKKK cascade" EXACT [GOC:signaling]
synonym: "negative regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "negative regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0000165 ! MAPK cascade

[Term]
id: GO:0043410
name: positive regulation of MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
synonym: "activation of MAPK cascade" NARROW [GOC:signaling]
synonym: "activation of MAPKKK cascade" NARROW []
synonym: "positive regulation of MAP kinase cascade" EXACT [GOC:signaling]
synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "positive regulation of MAPKKK cascade" EXACT [GOC:signaling]
synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "positive regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
synonym: "stimulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "stimulation of MAPKKK cascade" NARROW []
synonym: "up regulation of MAPKKK cascade" EXACT []
synonym: "up-regulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "up-regulation of MAPKKK cascade" EXACT []
synonym: "upregulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "upregulation of MAPKKK cascade" EXACT []
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0000165 ! MAPK cascade

[Term]
id: GO:0043411
name: obsolete myopalladin binding
namespace: molecular_function
def: "OBSOLETE. Binding to myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "myopalladin binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0043412
name: macromolecule modification
namespace: biological_process
def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
subset: goslim_pir
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0043413
name: macromolecule glycosylation
namespace: biological_process
def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl]
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0043414
name: macromolecule methylation
namespace: biological_process
def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0032259 ! methylation
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0043415
name: positive regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl]
synonym: "activation of skeletal muscle regeneration" NARROW []
synonym: "stimulation of skeletal muscle regeneration" NARROW []
synonym: "up regulation of skeletal muscle regeneration" EXACT []
synonym: "up-regulation of skeletal muscle regeneration" EXACT []
synonym: "upregulation of skeletal muscle regeneration" EXACT []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048639 ! positive regulation of developmental growth
relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043416
name: regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043417
name: negative regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl]
synonym: "down regulation of skeletal muscle regeneration" EXACT []
synonym: "down-regulation of skeletal muscle regeneration" EXACT []
synonym: "downregulation of skeletal muscle regeneration" EXACT []
synonym: "inhibition of skeletal muscle regeneration" NARROW []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0061045 ! negative regulation of wound healing
relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043418
name: homocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl]
synonym: "homocysteine breakdown" EXACT []
synonym: "homocysteine catabolism" EXACT []
synonym: "homocysteine degradation" EXACT []
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0050667 ! homocysteine metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0043419
name: urea catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl]
synonym: "urea breakdown" EXACT []
synonym: "urea catabolism" EXACT []
synonym: "urea decomposition" EXACT []
synonym: "urea degradation" EXACT []
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043605 ! amide catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0043420
name: anthranilate metabolic process
namespace: biological_process
alt_id: GO:0018869
def: "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [GOC:jl]
synonym: "2-aminobenzoate metabolic process" EXACT []
synonym: "2-aminobenzoate metabolism" EXACT []
synonym: "anthranilate metabolism" EXACT []
synonym: "anthranilic acid metabolic process" NARROW []
synonym: "anthranilic acid metabolism" NARROW []
synonym: "ortho-aminobenzoic acid metabolic process" NARROW []
synonym: "ortho-aminobenzoic acid metabolism" NARROW []
xref: UM-BBD_pathwayID:abz2
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0043421
name: anthranilate catabolic process
namespace: biological_process
alt_id: GO:0019259
def: "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [GOC:jl]
synonym: "2-aminobenzoate breakdown" EXACT []
synonym: "2-aminobenzoate catabolic process" EXACT []
synonym: "2-aminobenzoate catabolism" NARROW []
synonym: "2-aminobenzoate degradation" EXACT []
synonym: "anthranilate breakdown" EXACT []
synonym: "anthranilate catabolism" EXACT []
synonym: "anthranilate degradation" EXACT []
synonym: "anthranilic acid catabolic process" NARROW []
synonym: "anthranilic acid catabolism" NARROW []
synonym: "ortho-aminobenzoic acid catabolic process" NARROW []
synonym: "ortho-aminobenzoic acid catabolism" NARROW []
xref: MetaCyc:2AMINOBENZDEG-PWY
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043420 ! anthranilate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0043422
name: protein kinase B binding
namespace: molecular_function
def: "Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, https://doi.org/10.1016/S0092-8674(02)01083-8]
synonym: "Akt binding" EXACT []
synonym: "PKB binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043423
name: 3-phosphoinositide-dependent protein kinase binding
namespace: molecular_function
def: "Binding to a 3-phosphoinositide-dependent protein kinase." [GOC:jl]
synonym: "phosphatidylinositol-3-phosphate-dependent protein kinase binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043424
name: protein histidine kinase binding
namespace: molecular_function
def: "Binding to a protein histidine kinase." [GOC:jl]
synonym: "histidine kinase binding" EXACT []
synonym: "histidine-protein kinase binding" EXACT []
synonym: "protein-histidine kinase binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043425
name: bHLH transcription factor binding
namespace: molecular_function
def: "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210]
is_a: GO:0140297 ! DNA-binding transcription factor binding

[Term]
id: GO:0043426
name: MRF binding
namespace: molecular_function
alt_id: GO:0051576
alt_id: GO:0051577
alt_id: GO:0051578
alt_id: GO:0051579
def: "Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors." [PMID:10966875]
synonym: "Mrf4 binding" NARROW []
synonym: "Myf5 binding" NARROW []
synonym: "MyoD binding" NARROW []
synonym: "myogenin binding" NARROW []
is_a: GO:0043425 ! bHLH transcription factor binding

[Term]
id: GO:0043427
name: carbon fixation by 3-hydroxypropionate cycle
namespace: biological_process
def: "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028]
synonym: "3-hydroxypropionate cycle" EXACT []
synonym: "3-hydroxypropionate pathway" EXACT []
synonym: "hydroxypropionate cycle" EXACT []
synonym: "hydroxypropionate pathway" EXACT []
is_a: GO:0015977 ! carbon fixation

[Term]
id: GO:0043428
name: obsolete 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008425

[Term]
id: GO:0043429
name: obsolete 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008425

[Term]
id: GO:0043430
name: obsolete 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008425

[Term]
id: GO:0043431
name: obsolete 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344]
comment: This term was obsoleted because it represents a specific substrate of 3-demethylubiquinol-n 3-O-methyltransferase activity ; GO:0061542.
synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT []
synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0061542

[Term]
id: GO:0043433
name: negative regulation of DNA-binding transcription factor activity
namespace: biological_process
alt_id: GO:1904168
alt_id: GO:2000824
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of transcription factor activity" EXACT []
synonym: "down-regulation of transcription factor activity" EXACT []
synonym: "downregulation of transcription factor activity" EXACT []
synonym: "inhibition of transcription factor activity" NARROW []
synonym: "negative regulation of androgen receptor activity" NARROW []
synonym: "negative regulation of DNA binding transcription factor activity" EXACT []
synonym: "negative regulation of sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "negative regulation of thyroid hormone receptor activity" NARROW []
synonym: "negative regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity

[Term]
id: GO:0043434
name: response to peptide hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
synonym: "response to peptide hormone stimulus" EXACT [GOC:dos]
synonym: "response to polypeptide hormone stimulus" EXACT []
is_a: GO:0009725 ! response to hormone
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0043435
name: response to corticotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone]
synonym: "response to corticoliberin stimulus" EXACT []
synonym: "response to corticotropin-releasing factor stimulus" EXACT []
synonym: "response to corticotropin-releasing hormone stimulus" EXACT [GOC:dos]
synonym: "response to CRF stimulus" EXACT []
synonym: "response to CRH stimulus" EXACT []
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0043436
name: oxoacid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]
synonym: "keto acid metabolic process" EXACT []
synonym: "keto acid metabolism" EXACT []
synonym: "ketoacid metabolic process" EXACT []
synonym: "ketoacid metabolism" EXACT []
synonym: "oxo acid metabolic process" EXACT []
synonym: "oxo acid metabolism" EXACT []
synonym: "oxoacid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process

[Term]
id: GO:0043438
name: acetoacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH." [Wikipedia:Acetoacetic_acid]
synonym: "3-oxobutanoate metabolic process" EXACT []
synonym: "3-oxobutanoate metabolism" EXACT []
synonym: "3-oxobutanoic acid metabolic process" EXACT []
synonym: "3-oxobutanoic acid metabolism" EXACT []
synonym: "acetoacetate metabolic process" EXACT []
synonym: "acetoacetate metabolism" EXACT []
synonym: "acetoacetic acid metabolism" EXACT []
synonym: "beta ketobutyric acid metabolic process" EXACT []
synonym: "beta ketobutyric acid metabolism" EXACT []
synonym: "beta-ketobutyric acid metabolic process" EXACT []
synonym: "beta-ketobutyric acid metabolism" EXACT []
synonym: "diacetic acid metabolic process" EXACT []
synonym: "diacetic acid metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process
is_a: GO:1902224 ! ketone body metabolic process

[Term]
id: GO:0043441
name: acetoacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]
synonym: "acetoacetic acid anabolism" EXACT []
synonym: "acetoacetic acid biosynthesis" EXACT []
synonym: "acetoacetic acid formation" EXACT []
synonym: "acetoacetic acid synthesis" EXACT []
is_a: GO:0043438 ! acetoacetic acid metabolic process
is_a: GO:0046951 ! ketone body biosynthetic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0043442
name: acetoacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]
synonym: "acetoacetic acid breakdown" EXACT []
synonym: "acetoacetic acid catabolism" EXACT []
synonym: "acetoacetic acid degradation" EXACT []
is_a: GO:0019626 ! short-chain fatty acid catabolic process
is_a: GO:0043438 ! acetoacetic acid metabolic process
is_a: GO:0046952 ! ketone body catabolic process

[Term]
id: GO:0043443
name: obsolete acetone metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving acetone, propan-2-one." [GOC:jl]
comment: This term was obsoleted because it is not a biological process as defined by GO.
synonym: "2-propanone metabolic process" EXACT []
synonym: "2-propanone metabolism" EXACT []
synonym: "acetone metabolism" EXACT []
synonym: "dimethyl ketone metabolic process" EXACT []
synonym: "dimethyl ketone metabolism" EXACT []
synonym: "propan-2-one metabolic process" EXACT []
synonym: "propan-2-one metabolism" EXACT []
is_obsolete: true
consider: GO:0140977

[Term]
id: GO:0043444
name: obsolete acetone catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one." [GOC:jl]
comment: This term was obsoleted because it is not a biological process as defined by GO.
synonym: "2-propanone catabolic process" EXACT []
synonym: "2-propanone catabolism" EXACT []
synonym: "acetone breakdown" EXACT []
synonym: "acetone catabolism" EXACT []
synonym: "acetone degradation" EXACT []
synonym: "dimethyl ketone catabolic process" EXACT []
synonym: "dimethyl ketone catabolism" EXACT []
synonym: "propan-2-one catabolic process" EXACT []
synonym: "propan-2-one catabolism" EXACT []
is_obsolete: true
consider: GO:0140977

[Term]
id: GO:0043445
name: obsolete acetone biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of acetone, propan-2-one." [GOC:jl]
comment: This term was obsoleted because it is not a biological process as defined by GO.
synonym: "2-propanone biosynthesis" EXACT []
synonym: "2-propanone biosynthetic process" EXACT []
synonym: "acetone anabolism" EXACT []
synonym: "acetone biosynthesis" EXACT []
synonym: "acetone formation" EXACT []
synonym: "acetone synthesis" EXACT []
synonym: "dimethyl ketone biosynthesis" EXACT []
synonym: "dimethyl ketone biosynthetic process" EXACT []
synonym: "propan-2-one biosynthesis" EXACT []
synonym: "propan-2-one biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0043446
name: alkane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [GOC:jl, Wikipedia:Alkane]
subset: goslim_pir
synonym: "alkane metabolism" EXACT []
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0043447
name: alkane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [GOC:jl, Wikipedia:Alkane]
synonym: "alkane anabolism" EXACT []
synonym: "alkane biosynthesis" EXACT []
synonym: "alkane formation" EXACT []
synonym: "alkane synthesis" EXACT []
is_a: GO:0043446 ! alkane metabolic process
is_a: GO:0120251 ! hydrocarbon biosynthetic process

[Term]
id: GO:0043448
name: alkane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [GOC:jl, Wikipedia:Alkane]
synonym: "alkane breakdown" EXACT []
synonym: "alkane catabolism" EXACT []
synonym: "alkane degradation" EXACT []
is_a: GO:0043446 ! alkane metabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0043449
name: alkene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [GOC:jl, Wikipedia:Alkene]
subset: goslim_pir
synonym: "alkene metabolism" EXACT []
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:0043450
name: alkene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:jl, Wikipedia:Alkene]
synonym: "alkene anabolism" EXACT []
synonym: "alkene biosynthesis" EXACT []
synonym: "alkene formation" EXACT []
synonym: "alkene synthesis" EXACT []
is_a: GO:0043449 ! alkene metabolic process
is_a: GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:0043451
name: alkene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:jl, Wikipedia:Alkene]
synonym: "alkene breakdown" EXACT []
synonym: "alkene catabolism" EXACT []
synonym: "alkene degradation" EXACT []
is_a: GO:0043449 ! alkene metabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0043452
name: alkyne metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [GOC:jl, GOC:krc, Wikipedia:Alkyne]
subset: goslim_pir
synonym: "alkyne metabolism" EXACT []
is_a: GO:0120246 ! acetylenic compound metabolic process
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0043453
name: alkyne biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2." [GOC:jl, GOC:krc, Wikipedia:Alkyne]
synonym: "alkyne anabolism" EXACT []
synonym: "alkyne biosynthesis" EXACT []
synonym: "alkyne formation" EXACT []
synonym: "alkyne synthesis" EXACT []
is_a: GO:0043452 ! alkyne metabolic process
is_a: GO:0120247 ! acetylenic compound biosynthetic process
is_a: GO:0120251 ! hydrocarbon biosynthetic process

[Term]
id: GO:0043454
name: alkyne catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2." [GOC:jl, GOC:krc, Wikipedia:Alkyne]
synonym: "alkyne breakdown" EXACT []
synonym: "alkyne catabolism" EXACT []
synonym: "alkyne degradation" EXACT []
is_a: GO:0043452 ! alkyne metabolic process
is_a: GO:0120248 ! acetylenic compound catabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0043455
name: regulation of secondary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
synonym: "regulation of secondary metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0019748 ! secondary metabolic process

[Term]
id: GO:0043456
name: regulation of pentose-phosphate shunt
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl]
synonym: "regulation of pentose phosphate pathway" EXACT []
synonym: "regulation of pentose phosphate shunt" EXACT []
synonym: "regulation of pentose-phosphate pathway" EXACT []
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:1902031 ! regulation of NADP metabolic process
relationship: regulates GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0043457
name: regulation of cellular respiration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0045333 ! cellular respiration

[Term]
id: GO:0043459
name: obsolete response to short exposure to lithium ion
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444]
comment: This term was made obsolete because 'short' is not a quantitative or meaningful measurement of time.
synonym: "response to short exposure to lithium ion" EXACT []
is_obsolete: true

[Term]
id: GO:0043460
name: obsolete response to long exposure to lithium ion
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444]
comment: This term was made obsolete because 'long' is not a quantitative or meaningful measurement of time.
synonym: "response to long exposure to lithium ion" EXACT []
is_obsolete: true

[Term]
id: GO:0043461
name: proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, PMID:29514954]
synonym: "F-type ATPase complex assembly" EXACT []
is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly

[Term]
id: GO:0043462
name: regulation of ATP-dependent activity
namespace: biological_process
def: "Any process that modulates the rate of an ATP-dependent activity." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "regulation of adenosinetriphosphatase activity" EXACT []
synonym: "regulation of ATPase activity" EXACT []
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0043463
name: regulation of rhamnose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl]
synonym: "regulation of rhamnose breakdown" EXACT []
synonym: "regulation of rhamnose catabolism" EXACT []
synonym: "regulation of rhamnose degradation" EXACT []
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0019301 ! rhamnose catabolic process

[Term]
id: GO:0043464
name: malolactic fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948]
synonym: "L-malate fermentation" BROAD []
synonym: "malate fermentation" BROAD []
synonym: "malo-lactate fermentation" EXACT []
synonym: "malolactate fermentation" EXACT []
xref: Wikipedia:Malolactic_fermentation
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0043465
name: regulation of fermentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0006113 ! fermentation

[Term]
id: GO:0043466
name: pyrimidine nucleobase fermentation
namespace: biological_process
def: "The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP." [GOC:jl]
synonym: "pyrimidine base fermentation" EXACT [GOC:go_curators]
synonym: "pyrimidine fermentation" RELATED []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation

[Term]
id: GO:0043467
name: regulation of generation of precursor metabolites and energy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0043468
name: regulation of fucose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0019317 ! fucose catabolic process

[Term]
id: GO:0043469
name: regulation of D-xylose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0042843 ! D-xylose catabolic process

[Term]
id: GO:0043470
name: regulation of carbohydrate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009894 ! regulation of catabolic process
relationship: regulates GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0043471
name: obsolete regulation of cellular carbohydrate catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl]
comment: This term was obsoleted because it is not different from its parent, regulation of carbohydrate catabolic process ; GO:0043470.
is_obsolete: true
replaced_by: GO:0043470

[Term]
id: GO:0043472
name: IgD binding
namespace: molecular_function
def: "Binding to an immunoglobulin of a D isotype." [PMID:12886015]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0043473
name: pigmentation
namespace: biological_process
def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0043474
name: pigment metabolic process involved in pigmentation
namespace: biological_process
def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb]
synonym: "pigment metabolic process during pigmentation" RELATED [GOC:dph, GOC:tb]
synonym: "pigment metabolism during pigmentation" RELATED []
is_a: GO:0042440 ! pigment metabolic process
relationship: part_of GO:0043473 ! pigmentation

[Term]
id: GO:0043475
name: pigment metabolic process involved in pigment accumulation
namespace: biological_process
def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment." [GOC:jl]
synonym: "pigment metabolic process during pigment accumulation" RELATED [GOC:dph, GOC:tb]
synonym: "pigment metabolism during pigment accumulation" RELATED []
is_a: GO:0043474 ! pigment metabolic process involved in pigmentation
relationship: part_of GO:0043476 ! pigment accumulation

[Term]
id: GO:0043476
name: pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl]
synonym: "pigment accumulation in response to external stimulus" EXACT []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0043477
name: pigment biosynthetic process involved in pigment accumulation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation." [GOC:dph, GOC:jl, GOC:tb]
synonym: "pigment biosynthetic process during pigment accumulation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043475 ! pigment metabolic process involved in pigment accumulation
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0043478
name: pigment accumulation in response to UV light
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0009411 ! response to UV
is_a: GO:0043476 ! pigment accumulation

[Term]
id: GO:0043479
name: pigment accumulation in tissues in response to UV light
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0043478 ! pigment accumulation in response to UV light
is_a: GO:0043480 ! pigment accumulation in tissues

[Term]
id: GO:0043480
name: pigment accumulation in tissues
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl]
synonym: "organismal pigment accumulation" EXACT []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0043476 ! pigment accumulation

[Term]
id: GO:0043481
name: anthocyanin accumulation in tissues in response to UV light
namespace: biological_process
def: "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0043479 ! pigment accumulation in tissues in response to UV light

[Term]
id: GO:0043482
name: cellular pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl]
is_a: GO:0033059 ! cellular pigmentation
is_a: GO:0043476 ! pigment accumulation
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0043483
name: anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:dph, GOC:jl, GOC:tb]
synonym: "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED []
synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light" RELATED [GOC:dph, GOC:tb]
synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED []
is_a: GO:0009718 ! anthocyanin-containing compound biosynthetic process
is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation
relationship: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light

[Term]
id: GO:0043484
name: regulation of RNA splicing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0043485
name: endosome to pigment granule transport
namespace: biological_process
def: "The directed movement of substances from endosomes to pigment granules." [GOC:jl]
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0048757 ! pigment granule maturation

[Term]
id: GO:0043486
name: obsolete histone exchange
namespace: biological_process
def: "OBSOLETE. The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
comment: This term was obsoleted because it represents a molecular function, histone chaperone activity.
synonym: "histone chaperone" RELATED [GOC:vw]
synonym: "histone replacement" EXACT []
is_obsolete: true
consider: GO:0006338
consider: GO:0140713

[Term]
id: GO:0043487
name: regulation of RNA stability
namespace: biological_process
def: "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010608 ! post-transcriptional regulation of gene expression
is_a: GO:0051252 ! regulation of RNA metabolic process
is_a: GO:0065008 ! regulation of biological quality
relationship: regulates GO:0006401 ! RNA catabolic process

[Term]
id: GO:0043488
name: regulation of mRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]
is_a: GO:0043487 ! regulation of RNA stability
is_a: GO:0061013 ! regulation of mRNA catabolic process

[Term]
id: GO:0043489
name: RNA stabilization
namespace: biological_process
def: "Prevention of degradation of RNA molecules." [GOC:go_curators]
is_a: GO:0043487 ! regulation of RNA stability
is_a: GO:1902369 ! negative regulation of RNA catabolic process

[Term]
id: GO:0043490
name: malate-aspartate shuttle
namespace: biological_process
def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]
synonym: "malate aspartate shuttle" EXACT []
synonym: "malate/aspartate shuttle" EXACT []
synonym: "malate:aspartate shuttle" EXACT []
xref: Wikipedia:Malate-aspartate_shuttle
is_a: GO:1990542 ! mitochondrial transmembrane transport
relationship: part_of GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0043491
name: phosphatidylinositol 3-kinase/protein kinase B signal transduction
namespace: biological_process
def: "An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway." [PMID:20517722, PMID:22952397]
synonym: "AKT signal transduction" RELATED []
synonym: "AKT signaling" RELATED []
synonym: "AKT signaling cascade" RELATED []
synonym: "AKT signalling cascade" RELATED []
synonym: "phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" EXACT []
synonym: "PI3K-PKB/Akt pathway" EXACT []
synonym: "PI3K/Akt signal transduction" EXACT []
synonym: "PI3K/PKB signal transduction" EXACT []
synonym: "PKB signal transduction" RELATED []
synonym: "PKB signaling" RELATED []
synonym: "PKB signaling cascade" RELATED []
synonym: "PKB signalling cascade" RELATED []
synonym: "protein kinase B signal transduction" RELATED []
synonym: "protein kinase B signaling" RELATED []
synonym: "protein kinase B signaling cascade" RELATED []
synonym: "protein kinase B signalling cascade" RELATED []
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0043493
name: viral terminase complex
namespace: cellular_component
def: "A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides." [GOC:bf, GOC:bm, GOC:jl, GOC:mlg, PMID:18687036]
synonym: "phage terminase complex" NARROW [GOC:bm]
synonym: "virus terminase complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0043494
name: CLRC complex
namespace: cellular_component
def: "An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi." [GOC:vw, PMID:16127433, PMID:20211136]
synonym: "Clr4-Rik1-Cul4 complex" EXACT []
synonym: "CLRC ubiquitin ligase complex" EXACT []
synonym: "Rik1 E3 ubiquitin ligase complex" EXACT []
synonym: "Rik1-E3 ubiquitin ligase complex" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0035097 ! histone methyltransferase complex
is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex

[Term]
id: GO:0043495
name: protein-membrane adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle." [GOC:go_curators]
synonym: "anchoring" RELATED []
synonym: "membrane-membrane adaptor activity" NARROW []
synonym: "protein membrane adaptor" EXACT []
synonym: "protein membrane adaptor activity" EXACT []
synonym: "protein membrane anchor" RELATED []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0043496
name: regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb]
comment: Note that protein homodimerization is a molecular function: 'protein homodimerization activity ; GO:0042803'.
subset: gocheck_obsoletion_candidate
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:0043497
name: obsolete regulation of protein heterodimerization activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0043498
name: obsolete cell surface binding
namespace: molecular_function
def: "OBSOLETE. Binding to a component on the surface of a cell." [GOC:jl]
comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term.
synonym: "cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0005102
consider: GO:0007155
consider: GO:0009986
consider: GO:0046812

[Term]
id: GO:0043499
name: obsolete eukaryotic cell surface binding
namespace: molecular_function
def: "OBSOLETE. Binding to a component on the surface of a eukaryotic cell." [GOC:jl]
comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term.
synonym: "eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0005102
consider: GO:0006952
consider: GO:0009986
consider: GO:0046812

[Term]
id: GO:0043500
name: muscle adaptation
namespace: biological_process
def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
subset: goslim_pir
synonym: "muscle plasticity" RELATED []
is_a: GO:0003012 ! muscle system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0043501
name: skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation

[Term]
id: GO:0043502
name: regulation of muscle adaptation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle]
synonym: "regulation of muscle plasticity" RELATED []
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0090257 ! regulation of muscle system process
relationship: regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0043503
name: skeletal muscle fiber adaptation
namespace: biological_process
def: "Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle fiber plasticity" RELATED []
synonym: "skeletal muscle fibre plasticity" EXACT []
synonym: "skeletal myofiber plasticity" EXACT []
synonym: "skeletal myofibre plasticity" EXACT []
is_a: GO:0051716 ! cellular response to stimulus
relationship: part_of GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0043504
name: mitochondrial DNA repair
namespace: biological_process
def: "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976]
is_a: GO:0006281 ! DNA repair
is_a: GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:0043505
name: CENP-A containing nucleosome
namespace: cellular_component
def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641]
synonym: "CenH3 containing nucleosome" EXACT []
synonym: "CENP-S-T-W-X" EXACT [GOC:vw, PMID:22304917]
synonym: "centromere specific nucleosome" RELATED []
synonym: "centromere-specific nucleosome" RELATED [GOC:vw]
synonym: "centromeric nucleosome" RELATED []
synonym: "CNP-T-W-S-X complex" EXACT []
is_a: GO:0000786 ! nucleosome
relationship: part_of GO:0061638 ! CENP-A containing chromatin

[Term]
id: GO:0043506
name: regulation of JUN kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "regulation of JUNK activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity

[Term]
id: GO:0043507
name: positive regulation of JUN kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of JUNK activity" EXACT []
synonym: "stimulation of JNK activity" NARROW []
synonym: "up regulation of JNK activity" EXACT []
synonym: "up-regulation of JNK activity" EXACT []
synonym: "upregulation of JNK activity" EXACT []
is_a: GO:0043406 ! positive regulation of MAP kinase activity
is_a: GO:0043506 ! regulation of JUN kinase activity

[Term]
id: GO:0043508
name: negative regulation of JUN kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of JNK activity" EXACT []
synonym: "down-regulation of JNK activity" EXACT []
synonym: "downregulation of JNK activity" EXACT []
synonym: "inhibition of JNK activity" NARROW []
synonym: "negative regulation of JUNK activity" EXACT []
is_a: GO:0043407 ! negative regulation of MAP kinase activity
is_a: GO:0043506 ! regulation of JUN kinase activity
is_a: GO:0046329 ! negative regulation of JNK cascade

[Term]
id: GO:0043509
name: activin A complex
namespace: cellular_component
alt_id: GO:0048181
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043510
name: activin B complex
namespace: cellular_component
alt_id: GO:0048182
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043511
name: inhibin complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043512
name: inhibin A complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043513
name: inhibin B complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043514
name: interleukin-12 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512]
comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
synonym: "IL-12 complex" EXACT [GOC:mah]
synonym: "IL12A" NARROW [GOC:add]
synonym: "IL12B" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
synonym: "p40" NARROW [GOC:add]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043515
name: kinetochore binding
namespace: molecular_function
def: "Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl]
is_a: GO:0005488 ! binding

[Term]
id: GO:0043516
name: regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "regulation of p53 induced by DNA damage response" EXACT []
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
relationship: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043517
name: positive regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "activation of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "positive regulation of p53 induced by DNA damage response" EXACT []
synonym: "stimulation of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator
relationship: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043518
name: negative regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "negative regulation of p53 induced by DNA damage response" EXACT []
is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator
relationship: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043519
name: regulation of myosin II filament organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]
synonym: "regulation of myosin II filament assembly or disassembly" RELATED [GOC:mah]
synonym: "regulation of myosin II filament organisation" EXACT [GOC:mah]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: regulates GO:0031038 ! myosin II filament organization

[Term]
id: GO:0043520
name: regulation of myosin II filament assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0043519 ! regulation of myosin II filament organization
relationship: regulates GO:0031036 ! myosin II filament assembly

[Term]
id: GO:0043521
name: regulation of myosin II filament disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:0043519 ! regulation of myosin II filament organization
relationship: regulates GO:0031037 ! myosin II filament disassembly

[Term]
id: GO:0043522
name: leucine zipper domain binding
namespace: molecular_function
def: "Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158]
synonym: "leucine zipper binding" EXACT []
is_a: GO:0030275 ! LRR domain binding

[Term]
id: GO:0043523
name: regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of neuronal cells" EXACT []
synonym: "regulation of apoptosis of neurons" EXACT []
synonym: "regulation of neuron apoptosis" NARROW []
synonym: "regulation of neuron programmed cell death" EXACT []
synonym: "regulation of neuronal cell programmed cell death" EXACT []
synonym: "regulation of programmed cell death of neuronal cells" EXACT []
synonym: "regulation of programmed cell death, neurons" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043524
name: negative regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "down regulation of neuron apoptosis" EXACT []
synonym: "down-regulation of neuron apoptosis" EXACT []
synonym: "downregulation of neuron apoptosis" EXACT []
synonym: "inhibition of neuron apoptosis" NARROW []
synonym: "negative regulation of neuron apoptosis" NARROW []
synonym: "negative regulation of programmed cell death, neurons" EXACT []
synonym: "neuron survival" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
relationship: negatively_regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043525
name: positive regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "activation of neuron apoptosis" NARROW []
synonym: "positive regulation of neuron apoptosis" NARROW []
synonym: "positive regulation of programmed cell death, neurons" EXACT []
synonym: "stimulation of neuron apoptosis" NARROW []
synonym: "up regulation of neuron apoptosis" EXACT []
synonym: "up-regulation of neuron apoptosis" EXACT []
synonym: "upregulation of neuron apoptosis" EXACT []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
relationship: positively_regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043526
name: obsolete neuroprotection
namespace: biological_process
def: "OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [GOC:mtg_apoptosis, MSH:D017209, PMID:10208444, PMID:11909981, PMID:15905876]
comment: This term was made obsolete because it refers to assays rather than processes. If neuron death by apoptosis is assessed, consider using GO:0043523 regulation of neuron apoptotic process. If neuron death is assessed but the cell death modality isn't defined, refer to GO:0070997 neuron death. Where non-neuronal cells are involved, and/or processes other than cell death are described, please use other terms for annotation.
synonym: "neuroprotection" EXACT []
xref: Wikipedia:Neuroprotection
is_obsolete: true

[Term]
id: GO:0043527
name: tRNA methyltransferase complex
namespace: cellular_component
def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972]
subset: goslim_pir
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0043528
name: tRNA (m2G10) methyltransferase complex
namespace: cellular_component
def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842]
is_a: GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0043529
name: GET complex
namespace: cellular_component
def: "An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins." [GOC:krc, GOC:vw, PMID:16269340, PMID:18724936, PMID:32910895]
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:0043530
name: adenosine 5'-monophosphoramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111, RHEA:67916]
synonym: "adenosine 5' monophosphoramidase activity" EXACT []
synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT []
xref: RHEA:67916
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043531
name: ADP binding
namespace: molecular_function
def: "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]
synonym: "adenosine 5'-diphosphate binding" EXACT []
synonym: "adenosine diphosphate binding" EXACT []
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0043532
name: angiostatin binding
namespace: molecular_function
def: "Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043533
name: inositol 1,3,4,5 tetrakisphosphate binding
namespace: molecular_function
def: "Binding to inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators]
synonym: "InsP4 binding" EXACT []
synonym: "IP4 binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0043534
name: blood vessel endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264]
is_a: GO:0043542 ! endothelial cell migration

[Term]
id: GO:0043535
name: regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
is_a: GO:0010594 ! regulation of endothelial cell migration
relationship: regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043536
name: positive regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "activation of blood vessel endothelial cell migration" NARROW []
synonym: "stimulation of blood vessel endothelial cell migration" NARROW []
synonym: "up regulation of blood vessel endothelial cell migration" EXACT []
synonym: "up-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "upregulation of blood vessel endothelial cell migration" EXACT []
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043537
name: negative regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "down regulation of blood vessel endothelial cell migration" EXACT []
synonym: "down-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "downregulation of blood vessel endothelial cell migration" EXACT []
synonym: "inhibition of blood vessel endothelial cell migration" NARROW []
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043538
name: obsolete regulation of actin phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0043539
name: protein serine/threonine kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]
synonym: "protein ser/thr kinase activator activity" EXACT []
is_a: GO:0030295 ! protein kinase activator activity

[Term]
id: GO:0043540
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
namespace: cellular_component
def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so]
comment: Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future.
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex" NARROW []
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex" NARROW []
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex" NARROW []
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex" NARROW []
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0043541
name: UDP-N-acetylglucosamine transferase complex
namespace: cellular_component
def: "A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0043542
name: endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0043543
name: protein acylation
namespace: biological_process
def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl]
subset: gocheck_obsoletion_candidate
subset: goslim_yeast
synonym: "protein amino acid acylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0043544
name: lipoamide binding
namespace: molecular_function
def: "Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators]
is_a: GO:0033218 ! amide binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043545
name: molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
synonym: "Moco metabolic process" EXACT []
synonym: "Moco metabolism" EXACT []
synonym: "molybdopterin cofactor metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0043546
name: molybdopterin cofactor binding
namespace: molecular_function
def: "Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
synonym: "Moco binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0043547
name: positive regulation of GTPase activity
namespace: biological_process
alt_id: GO:0032320
alt_id: GO:0032321
alt_id: GO:0032850
alt_id: GO:0032851
alt_id: GO:0032852
alt_id: GO:0032853
alt_id: GO:0032854
alt_id: GO:0032855
alt_id: GO:0043089
def: "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of GTPase activity" NARROW []
synonym: "positive regulation of ARF GTPase activity" NARROW []
synonym: "positive regulation of Cdc42 GTPase activity" NARROW []
synonym: "positive regulation of Rab GTPase activity" NARROW []
synonym: "positive regulation of Rac GTPase activity" NARROW []
synonym: "positive regulation of Ral GTPase activity" NARROW []
synonym: "positive regulation of Ran GTPase activity" NARROW []
synonym: "positive regulation of Rap GTPase activity" NARROW []
synonym: "positive regulation of Ras GTPase activity" NARROW []
synonym: "positive regulation of Rho GTPase activity" NARROW []
synonym: "stimulation of ARF GTPase activity" NARROW []
synonym: "stimulation of Cdc42 GTPase activity" NARROW []
synonym: "stimulation of GTPase activity" NARROW []
synonym: "stimulation of Rab GTPase activity" NARROW []
synonym: "stimulation of Rac GTPase activity" NARROW []
synonym: "stimulation of Ral GTPase activity" NARROW []
synonym: "stimulation of Ran GTPase activity" NARROW []
synonym: "stimulation of Rap GTPase activity" NARROW []
synonym: "stimulation of Ras GTPase activity" NARROW []
synonym: "stimulation of Rho GTPase activity" NARROW []
synonym: "up regulation of ARF GTPase activity" NARROW []
synonym: "up regulation of Cdc42 GTPase activity" NARROW []
synonym: "up regulation of GTPase activity" EXACT []
synonym: "up regulation of Rab GTPase activity" NARROW []
synonym: "up regulation of Rac GTPase activity" NARROW []
synonym: "up regulation of Ral GTPase activity" NARROW []
synonym: "up regulation of Ran GTPase activity" NARROW []
synonym: "up regulation of Rap GTPase activity" NARROW []
synonym: "up regulation of Ras GTPase activity" NARROW []
synonym: "up regulation of Rho GTPase activity" NARROW []
synonym: "up-regulation of ARF GTPase activity" NARROW []
synonym: "up-regulation of Cdc42 GTPase activity" NARROW []
synonym: "up-regulation of GTPase activity" EXACT []
synonym: "up-regulation of Rab GTPase activity" NARROW []
synonym: "up-regulation of Rac GTPase activity" NARROW []
synonym: "up-regulation of Ral GTPase activity" NARROW []
synonym: "up-regulation of Ran GTPase activity" NARROW []
synonym: "up-regulation of Rap GTPase activity" NARROW []
synonym: "up-regulation of Ras GTPase activity" NARROW []
synonym: "up-regulation of Rho GTPase activity" NARROW []
synonym: "upregulation of ARF GTPase activity" NARROW []
synonym: "upregulation of Cdc42 GTPase activity" NARROW []
synonym: "upregulation of GTPase activity" EXACT []
synonym: "upregulation of Rab GTPase activity" NARROW []
synonym: "upregulation of Rac GTPase activity" NARROW []
synonym: "upregulation of Ral GTPase activity" NARROW []
synonym: "upregulation of Ran GTPase activity" NARROW []
synonym: "upregulation of Rap GTPase activity" NARROW []
synonym: "upregulation of Ras GTPase activity" NARROW []
synonym: "upregulation of Rho GTPase activity" NARROW []
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0043548
name: phosphatidylinositol 3-kinase binding
namespace: molecular_function
def: "Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069]
synonym: "phosphoinositide 3-kinase binding" EXACT []
synonym: "PI3K binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043549
name: regulation of kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]
subset: gocheck_obsoletion_candidate
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0043550
name: regulation of lipid kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf]
subset: gocheck_obsoletion_candidate
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:0043551
name: obsolete regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of phosphoinositide 3-kinase activity" EXACT []
is_obsolete: true
consider: GO:0035014

[Term]
id: GO:0043552
name: obsolete positive regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of phosphatidylinositol 3-kinase activity" NARROW []
synonym: "positive regulation of phosphoinositide 3-kinase activity" EXACT []
synonym: "stimulation of phosphatidylinositol 3-kinase activity" NARROW []
synonym: "up regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "up-regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "upregulation of phosphatidylinositol 3-kinase activity" EXACT []
is_obsolete: true
consider: GO:0141038

[Term]
id: GO:0043553
name: obsolete negative regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "down-regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "downregulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "inhibition of phosphatidylinositol 3-kinase activity" NARROW []
synonym: "negative regulation of phosphoinositide 3-kinase activity" EXACT []
synonym: "negative regulation of PI3K activity" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0141039

[Term]
id: GO:0043554
name: aerobic respiration, using arsenite as electron donor
namespace: biological_process
def: "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg]
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0043555
name: regulation of translation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
synonym: "translational stress response" EXACT []
is_a: GO:0006417 ! regulation of translation
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0043556
name: regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]
is_a: GO:0032055 ! negative regulation of translation in response to stress
relationship: part_of GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0043557
name: regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]
is_a: GO:0043555 ! regulation of translation in response to stress
relationship: part_of GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0043558
name: regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl]
synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0043559
name: insulin binding
namespace: molecular_function
def: "Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732]
is_a: GO:0005515 ! protein binding
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0043560
name: insulin receptor substrate binding
namespace: molecular_function
def: "Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233]
synonym: "insulin receptor substrate [protein] binding" EXACT []
synonym: "IRS [protein] binding" EXACT []
synonym: "IRS binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043561
name: regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0043557 ! regulation of translation in response to osmotic stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0043562
name: cellular response to nitrogen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl]
is_a: GO:0031669 ! cellular response to nutrient levels

[Term]
id: GO:0043563
name: obsolete odorant transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells." [GOC:jl]
is_obsolete: true

[Term]
id: GO:0043564
name: Ku70:Ku80 complex
namespace: cellular_component
def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]
synonym: "Ku70:Ku80 heterodimer" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0043565
name: sequence-specific DNA binding
namespace: molecular_function
def: "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
synonym: "sequence specific DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0043567
name: regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "regulation of IGF receptor signaling pathway" EXACT []
synonym: "regulation of IGF receptor signalling pathway" EXACT []
synonym: "regulation of insulin-like growth factor receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043568
name: positive regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "activation of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of IGF receptor signaling pathway" EXACT []
synonym: "positive regulation of IGF receptor signalling pathway" EXACT []
synonym: "positive regulation of insulin-like growth factor receptor signalling pathway" EXACT []
synonym: "stimulation of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of insulin-like growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway
relationship: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043569
name: negative regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "down regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of IGF receptor signaling pathway" EXACT []
synonym: "negative regulation of IGF receptor signalling pathway" EXACT []
synonym: "negative regulation of insulin-like growth factor receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043570
name: maintenance of DNA repeat elements
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0043571
name: maintenance of CRISPR repeat elements
namespace: biological_process
def: "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354]
synonym: "CRISPR element metabolic process" RELATED []
synonym: "CRISPR element metabolism" RELATED []
synonym: "maintenance of clustered regularly interspaced short palindromic repeat elements" EXACT []
is_a: GO:0043570 ! maintenance of DNA repeat elements

[Term]
id: GO:0043572
name: plastid fission
namespace: biological_process
def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl]
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0043573
name: leucoplast fission
namespace: biological_process
def: "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl]
is_a: GO:0043572 ! plastid fission

[Term]
id: GO:0043574
name: peroxisomal transport
namespace: biological_process
def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0043575
name: detection of osmotic stimulus
namespace: biological_process
def: "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0043576
name: regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system

[Term]
id: GO:0043577
name: chemotropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, PMID:10087613]
xref: Wikipedia:Chemotropism
is_a: GO:0009606 ! tropism
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0043578
name: nuclear matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah]
synonym: "nuclear matrix organisation" EXACT []
synonym: "nuclear matrix organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleoskeleton organization" EXACT [GOC:tb]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0043579
name: elaioplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl]
synonym: "elaioplast organisation" EXACT []
synonym: "elaioplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009659 ! leucoplast organization

[Term]
id: GO:0043580
name: periplasmic space organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah]
synonym: "periplasmic space organisation" EXACT [GOC:mah]
synonym: "periplasmic space organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043581
name: obsolete mycelium development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium consists of a mass of branching, thread-like hyphae." [GOC:jl, ISBN:1580085792, PMID:12832397]
comment: The reason for obsoletion is that the term is ambiguous. Three more clearly defined terms have been created that should be considered in its place.
is_obsolete: true
consider: GO:0097736
consider: GO:0097737
consider: GO:0097738

[Term]
id: GO:0043582
name: sporangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores." [GOC:jl, Wikipedia:Sporagium]
synonym: "sporangia development" EXACT []
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0043583
name: ear development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]
synonym: "hearing organ development" EXACT []
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0043584
name: nose development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl]
synonym: "nasus development" EXACT []
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0043585
name: nose morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl]
synonym: "nasus morphogenesis" EXACT []
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043584 ! nose development

[Term]
id: GO:0043586
name: tongue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]
synonym: "glossa development" NARROW []
synonym: "lingua development" NARROW []
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0043587
name: tongue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]
synonym: "glossa morphogenesis" NARROW []
synonym: "lingua morphogenesis" EXACT []
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043586 ! tongue development

[Term]
id: GO:0043588
name: skin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
synonym: "animal skin development" EXACT []
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0043589
name: skin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0043590
name: bacterial nucleoid
namespace: cellular_component
def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl]
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0043591
name: endospore external encapsulating structure
namespace: cellular_component
alt_id: GO:0055030
def: "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041]
subset: goslim_pir
synonym: "endospore wall" EXACT [GOC:mah]
synonym: "peptidoglycan-based spore wall" EXACT [GOC:mtg_sensu]
synonym: "spore wall" BROAD [GOC:mtg_sensu]
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0043592
name: exosporium
namespace: cellular_component
def: "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg]
synonym: "epispore" RELATED []
synonym: "exospore" RELATED []
synonym: "perispore" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043593
name: endospore coat
namespace: cellular_component
def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043594
name: outer endospore membrane
namespace: cellular_component
def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg]
is_a: GO:0019867 ! outer membrane
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043595
name: endospore cortex
namespace: cellular_component
def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043596
name: nuclear replication fork
namespace: cellular_component
def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0005657 ! replication fork
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0043597
name: cytoplasmic replication fork
namespace: cellular_component
def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0005657 ! replication fork
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0043598
name: cytoplasmic DNA replication factor C complex
namespace: cellular_component
def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species." [GOC:mtg_sensu, PMID:14646196, PMID:16172520]
synonym: "cytoplasmic clamp loader" EXACT []
synonym: "cytoplasmic RFC" EXACT []
is_a: GO:0005663 ! DNA replication factor C complex
relationship: part_of GO:0043600 ! cytoplasmic replisome

[Term]
id: GO:0043599
name: nuclear DNA replication factor C complex
namespace: cellular_component
def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842]
synonym: "nuclear RFC" EXACT []
is_a: GO:0005663 ! DNA replication factor C complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0043600
name: cytoplasmic replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu]
synonym: "prokaryotic replisome" EXACT []
is_a: GO:0030894 ! replisome
relationship: part_of GO:0043597 ! cytoplasmic replication fork

[Term]
id: GO:0043601
name: nuclear replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0030894 ! replisome
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043596 ! nuclear replication fork

[Term]
id: GO:0043602
name: nitrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]
synonym: "nitrate disassimilation" EXACT []
synonym: "nitrate dissimilation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042126 ! nitrate metabolic process

[Term]
id: GO:0043603
name: amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "amide metabolism" EXACT []
synonym: "cellular amide metabolic process" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0043604
name: amide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0043605
name: amide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]
synonym: "cellular amide catabolic process" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0043606
name: formamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl]
synonym: "formamide metabolism" EXACT []
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0043607
name: formamide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl]
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0043606 ! formamide metabolic process

[Term]
id: GO:0043608
name: formamide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl]
is_a: GO:0043605 ! amide catabolic process
is_a: GO:0043606 ! formamide metabolic process

[Term]
id: GO:0043609
name: regulation of carbon utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of carbon utilization." [GOC:jl]
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: regulates GO:0015976 ! carbon utilization

[Term]
id: GO:0043610
name: regulation of carbohydrate utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of carbohydrate utilization." [GOC:jl]
synonym: "regulation of sugar utilization" NARROW [GOC:mcc2]
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: regulates GO:0009758 ! carbohydrate utilization

[Term]
id: GO:0043611
name: isoprene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoprene, C5H8." [GOC:jl]
synonym: "2-methyl-1,3-butadiene metabolic process" EXACT []
synonym: "2-methyl-1,3-butadiene metabolism" EXACT []
synonym: "hemiterpene metabolic process" EXACT []
synonym: "hemiterpene metabolism" EXACT []
synonym: "isoprene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:0043612
name: isoprene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoprene, C5H8." [GOC:jl]
synonym: "2-methyl-1,3-butadiene biosynthesis" EXACT []
synonym: "2-methyl-1,3-butadiene biosynthetic process" EXACT []
synonym: "hemiterpene biosynthesis" EXACT []
synonym: "hemiterpene biosynthetic process" EXACT []
is_a: GO:0043611 ! isoprene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:0043613
name: isoprene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8." [GOC:jl]
synonym: "2-methyl-1,3-butadiene catabolic process" EXACT []
synonym: "2-methyl-1,3-butadiene catabolism" EXACT []
synonym: "hemiterpene catabolic process" EXACT []
synonym: "hemiterpene catabolism" EXACT []
is_a: GO:0043611 ! isoprene metabolic process
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0043614
name: multi-eIF complex
namespace: cellular_component
def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc]
synonym: "multifactor translation initiation factor (eIF) complex" EXACT []
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0043615
name: astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators]
synonym: "astrocyte migration" EXACT []
synonym: "astrocytic glial cell migration" EXACT []
is_a: GO:0008347 ! glial cell migration

[Term]
id: GO:0043616
name: keratinocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0043617
name: cellular response to sucrose starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0043618
name: obsolete regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0033554

[Term]
id: GO:0043619
name: obsolete regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0034599

[Term]
id: GO:0043620
name: obsolete regulation of DNA-templated transcription in response to stress
namespace: biological_process
def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of DNA-dependent transcription in response to stress" EXACT [GOC:txnOH]
is_obsolete: true
consider: GO:0006355
consider: GO:0033554

[Term]
id: GO:0043621
name: obsolete protein self-association
namespace: molecular_function
def: "OBSOLETE. Binding to a domain within the same polypeptide." [GOC:jl]
comment: Out of scope; capture mechanistic information about binding.
synonym: "intramolecular protein binding" EXACT []
synonym: "protein self association" EXACT []
synonym: "protein self binding" EXACT []
is_obsolete: true

[Term]
id: GO:0043622
name: cortical microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
synonym: "cortical microtubule cytoskeleton organization" EXACT []
synonym: "cortical microtubule organisation" EXACT []
synonym: "cortical microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030865 ! cortical cytoskeleton organization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0043625
name: delta DNA polymerase complex
namespace: cellular_component
alt_id: GO:0005659
def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]
synonym: "delta-DNA polymerase complex" EXACT []
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0043626
name: PCNA complex
namespace: cellular_component
def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735]
synonym: "PCNA homotrimer" EXACT []
synonym: "proliferating cell nuclear antigen complex" EXACT []
synonym: "sliding clamp" BROAD []
is_a: GO:0044796 ! DNA polymerase processivity factor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0043627
name: response to estrogen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732]
synonym: "response to 17alpha-ethynylestradiol" RELATED []
synonym: "response to estrogen stimulus" EXACT [GOC:dos]
synonym: "response to oestrogen stimulus" EXACT []
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0043628
name: regulatory ncRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a regulatory non-coding RNA molecule." [GOC:jl]
synonym: "ncRNA 3' end processing" BROAD []
synonym: "ncRNA 3'-end processing" BROAD []
synonym: "small regulatory ncRNA 3'-end processing" NARROW []
is_a: GO:0031123 ! RNA 3'-end processing
is_a: GO:0070918 ! regulatory ncRNA processing

[Term]
id: GO:0043629
name: obsolete ncRNA polyadenylation
namespace: biological_process
def: "OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation." [GOC:dgf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "non-coding RNA polyadenylation" EXACT []
is_obsolete: true

[Term]
id: GO:0043630
name: obsolete ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "OBSOLETE. The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:dph, GOC:jl, GOC:tb]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "ncRNA polyadenylation involved in poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw]
is_obsolete: true
replaced_by: GO:0043634

[Term]
id: GO:0043631
name: obsolete RNA polyadenylation
namespace: biological_process
def: "OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0043632
name: modification-dependent macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]
is_a: GO:0009057 ! macromolecule catabolic process

[Term]
id: GO:0043633
name: polyadenylation-dependent RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:dgf, GOC:jl, GOC:krc]
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process

[Term]
id: GO:0043634
name: polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc]
synonym: "poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process

[Term]
id: GO:0043635
name: methylnaphthalene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687]
synonym: "1-methylnaphthalene catabolic process" NARROW []
synonym: "1-methylnaphthalene catabolism" NARROW []
synonym: "1-MN catabolic process" RELATED []
synonym: "1-MN catabolism" RELATED []
synonym: "2-methylnaphthalene catabolic process" NARROW []
synonym: "2-methylnaphthalene catabolism" NARROW []
synonym: "2-MN catabolic process" RELATED []
synonym: "2-MN catabolism" RELATED []
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0043636
name: bisphenol A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [GOC:jl, Wikipedia:Bisphenol_A]
synonym: "bisphenol-A catabolic process" EXACT []
synonym: "bisphenol-A catabolism" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0043637
name: puromycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, PMID:8226694, Wikipedia:Puromycin]
synonym: "puromycin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0043638
name: puromycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, Wikipedia:Puromycin]
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0043637 ! puromycin metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0043639
name: benzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl]
synonym: "benzoate breakdown" EXACT []
synonym: "benzoate catabolism" EXACT []
synonym: "benzoate degradation" EXACT []
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0043640
name: benzoate catabolic process via hydroxylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503]
synonym: "benzoate breakdown via hydroxylation" EXACT []
synonym: "benzoate degradation via hydroxylation" EXACT []
xref: MetaCyc:PWY-2503
is_a: GO:0043639 ! benzoate catabolic process

[Term]
id: GO:0043641
name: novobiocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl]
synonym: "novobiocin metabolism" EXACT []
xref: Wikipedia:Novobiocin
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0043642
name: novobiocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl]
xref: Wikipedia:Novobiocin
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0043641 ! novobiocin metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0043643
name: tetracycline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, Wikipedia:Tetracycline]
synonym: "tetracyclin metabolic process" EXACT []
synonym: "tetracyclin metabolism" EXACT []
synonym: "tetracycline metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0043644
name: tetracycline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, Wikipedia:Tetracycline]
synonym: "tetracyclin biosynthesis" EXACT []
synonym: "tetracyclin biosynthetic process" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043643 ! tetracycline metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0043645
name: cephalosporin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, Wikipedia:Cephalosporin]
synonym: "cephalosporin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process

[Term]
id: GO:0043646
name: cephalosporin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, Wikipedia:Cephalosporin]
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0043645 ! cephalosporin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0043647
name: inositol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:jl]
synonym: "inositol phosphate metabolism" EXACT []
synonym: "myo-inositol phosphate metabolic process" NARROW []
synonym: "myo-inositol phosphate metabolism" NARROW []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:0043648
name: dicarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
synonym: "dicarboxylate metabolic process" EXACT []
synonym: "dicarboxylate metabolism" EXACT []
synonym: "dicarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0043649
name: dicarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "dicarboxylate catabolic process" EXACT []
synonym: "dicarboxylate catabolism" EXACT []
synonym: "dicarboxylic acid breakdown" EXACT []
synonym: "dicarboxylic acid catabolism" EXACT []
synonym: "dicarboxylic acid degradation" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0043650
name: dicarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "dicarboxylate biosynthesis" EXACT []
synonym: "dicarboxylate biosynthetic process" EXACT []
synonym: "dicarboxylic acid anabolism" EXACT []
synonym: "dicarboxylic acid biosynthesis" EXACT []
synonym: "dicarboxylic acid formation" EXACT []
synonym: "dicarboxylic acid synthesis" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0043651
name: linoleic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [Wikipedia:Linoleic_Acid]
synonym: "linoleic acid metabolism" EXACT []
xref: Wikipedia:Linoleic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0043652
name: engulfment of apoptotic cell
namespace: biological_process
def: "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]
comment: This term should be used to annotate gene products from the engulfing cell that facilitate phagocytosis of apoptotic cells. It should not be mistaken with GO:0070782 'phosphatidylserine exposure on apoptotic cell surface', a process occurring in apoptotic cells that acts as a signal for engulfing cells. If gene products involved in such instances of phosphatidylserine exposure are shown to have a positive effect on engulfment, they may be annotated to GO:1901076 'positive regulation of engulfment of apoptotic cell'.
synonym: "engulfment of apoptotic cell corpse" EXACT []
synonym: "engulfment of cell corpse" EXACT []
is_a: GO:0006911 ! phagocytosis, engulfment
relationship: part_of GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:0043653
name: mitochondrial fragmentation involved in apoptotic process
namespace: biological_process
def: "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:mtg_apoptosis, GOC:rk, PMID:12867994]
comment: Although most of the processes described under 'apoptotic mitochondrial changes' take place during the signaling phase of apoptosis, 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed there. It is still controversial whether this process is involved in the signaling phase of apoptosis or not, so it was placed under the more generic 'apoptotic mitochondrial changes' parent rather than linked to the signaling or the execution phase until further research clarifies the matter.
synonym: "mitochondrial fission during apoptosis" RELATED [GOC:dph, GOC:tb]
synonym: "mitochondrial fragmentation involved in apoptosis" NARROW []
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0043654
name: recognition of apoptotic cell
namespace: biological_process
def: "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015]
synonym: "detection of apoptotic cell" EXACT []
synonym: "detection of apoptotic cell corpse" EXACT []
synonym: "detection of cell corpse" EXACT []
synonym: "recognition of apoptotic cell corpse" EXACT []
synonym: "recognition of cell corpse" EXACT []
is_a: GO:0006910 ! phagocytosis, recognition
relationship: part_of GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:0043655
name: host extracellular space
namespace: cellular_component
def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc]
synonym: "extracellular space of host" EXACT []
is_a: GO:0018995 ! host cellular component

[Term]
id: GO:0043656
name: host intracellular region
namespace: cellular_component
def: "That space within the plasma membrane of a host cell." [GOC:cc]
synonym: "host intracellular" EXACT []
synonym: "intracellular region of host" EXACT []
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0043657
name: host cell
namespace: cellular_component
def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl]
is_a: GO:0018995 ! host cellular component

[Term]
id: GO:0043658
name: host symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc]
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0043659
name: symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc]
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0043660
name: bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc]
is_a: GO:0043659 ! symbiosome

[Term]
id: GO:0043661
name: peribacteroid membrane
namespace: cellular_component
def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043662
name: peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043663
name: host bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc]
is_a: GO:0043658 ! host symbiosome

[Term]
id: GO:0043664
name: host peribacteroid membrane
namespace: cellular_component
def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043665
name: host peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043666
name: obsolete regulation of phosphoprotein phosphatase activity
namespace: biological_process
alt_id: GO:0032512
alt_id: GO:0034047
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "regulation of calcineurin activity" NARROW []
synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "regulation of protein phosphatase type 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "regulation of protein phosphatase type 2A activity" NARROW []
synonym: "regulation of protein phosphatase type 2B activity" NARROW []
is_obsolete: true

[Term]
id: GO:0043667
name: pollen wall
namespace: cellular_component
def: "The wall surrounding a mature pollen grain; a multilayered structure consisting of a pectocellulosic intine surrounded by a sporopollenin-based exine, which itself contains two layers, the inner nexine and the outer sexine." [GOC:fz, PMID:15131249]
synonym: "microspore wall" EXACT []
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0043668
name: exine
namespace: cellular_component
def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [https://doi.org/10.1038/220389a0]
comment: Note that the exine is highly resistant to strong acids and bases.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043669
name: ectexine
namespace: cellular_component
def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [PMID:28904424]
comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043670
name: foot layer
namespace: cellular_component
def: "The inner layer of the ectexine." [PMID:28904424]
synonym: "nexine 1" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043669 ! ectexine

[Term]
id: GO:0043671
name: endexine
namespace: cellular_component
def: "The inner part of the exine, which stains." [PMID:28904424]
comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043672
name: nexine
namespace: cellular_component
def: "The inner, non-sculptured part of the exine which lies below the sexine." [PMID:5722147]
comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043673
name: sexine
namespace: cellular_component
def: "The outer, sculptured layer of the exine, which lies above the nexine." [PMID:5722147]
comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043674
name: columella
namespace: cellular_component
def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [https://en.wikipedia.org/wiki/Columella_(botany)]
synonym: "sexine 1" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043675
name: sculpture element
namespace: cellular_component
def: "The third layer of the sexine." [https://doi.org/10.1007/978-3-319-71365-6_3]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043676
name: tectum
namespace: cellular_component
def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [PMID:33706055]
synonym: "sexine 2" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043677
name: obsolete germination pore
namespace: cellular_component
def: "OBSOLETE. A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [Wikipedia:Germ_pore]
comment: This term was made obsolete because it was poorly named and poorly defined.
synonym: "germ pore" EXACT []
xref: Wikipedia:Germ_pore
is_obsolete: true

[Term]
id: GO:0043678
name: intine
namespace: cellular_component
def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [PMID:33706055]
comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043679
name: axon terminus
namespace: cellular_component
def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
synonym: "axon terminal" EXACT [NIF_Subcellular:sao2007137787]
synonym: "axon terminal specialization" RELATED []
synonym: "nerve ending" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090512
is_a: GO:0044306 ! neuron projection terminus
is_a: GO:0098793 ! presynapse
relationship: part_of GO:0150034 ! distal axon

[Term]
id: GO:0043680
name: filiform apparatus
namespace: cellular_component
def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005618 ! cell wall

[Term]
id: GO:0043682
name: P-type divalent copper transporter activity
namespace: molecular_function
alt_id: GO:0004008
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)." [RHEA:10376]
synonym: "copper exporting ATPase activity" BROAD []
synonym: "copper transmembrane transporter activity, phosphorylative mechanism" BROAD []
synonym: "copper-exporting ATPase activity" NARROW []
synonym: "copper-translocating P-type ATPase activity" BROAD []
synonym: "copper-transporting ATPase activity" BROAD []
synonym: "Cu(2+)-exporting ATPase activity" RELATED [EC:7.2.2.9]
synonym: "Cu2+-exporting ATPase activity" RELATED [EC:7.2.2.9]
xref: EC:7.2.2.9
xref: MetaCyc:TRANS-RXN-178
xref: Reactome:R-HSA-3697838 "ATP7A transfers Cu from ATOX1 to SOD3"
xref: Reactome:R-HSA-6803545 "ATP7A transports cytosolic Cu2+ to phagosomal lumen"
xref: Reactome:R-HSA-936802 "ATP7A transports cytosolic Cu2+ to extracellular region"
xref: Reactome:R-HSA-936895 "ATP7B transports cytosolic Cu2+ to Golgi lumen"
xref: RHEA:10376
is_a: GO:0005375 ! copper ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0043683
name: type IV pilus assembly
namespace: biological_process
def: "The assembly from its constituent parts of a type IV pilus." [GOC:jl, GOC:ml, PMID:31784891]
synonym: "type IV fimbria assembly" EXACT []
synonym: "type IV fimbria biogenesis" EXACT []
synonym: "type IV fimbriae assembly" EXACT []
synonym: "type IV fimbriae biogenesis" EXACT []
synonym: "type IV fimbrial assembly" EXACT []
synonym: "type IV fimbrial biogenesis" EXACT []
synonym: "type IV fimbrium assembly" EXACT []
synonym: "type IV fimbrium biogenesis" EXACT []
synonym: "type IV pilus biogenesis" RELATED []
is_a: GO:0009297 ! pilus assembly

[Term]
id: GO:0043684
name: type IV secretion system complex
namespace: cellular_component
def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml]
synonym: "T4SS complex" EXACT []
synonym: "type IV protein secretion system complex" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0043685
name: conversion of glutamyl-tRNA to glutaminyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308]
comment: Note that this process has been observed in some archaeal and bacterial species.
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0043686
name: co-translational protein modification
namespace: biological_process
def: "The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome." [GOC:jsg]
comment: This term should only be used to annotate a protein modification process that occurs after the start of translation but while the protein is still on the ribosome.
synonym: "co-translational amino acid modification" EXACT []
synonym: "co-translational modification" EXACT []
synonym: "cotranslational amino acid modification" EXACT []
synonym: "cotranslational modification" EXACT []
synonym: "cotranslational protein modification" EXACT []
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0043687
name: post-translational protein modification
namespace: biological_process
def: "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]
comment: This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term.
synonym: "post-translational amino acid modification" EXACT []
synonym: "post-translational modification" EXACT []
synonym: "posttranslational amino acid modification" EXACT []
synonym: "posttranslational modification" EXACT []
synonym: "posttranslational protein modification" EXACT []
synonym: "PTM" EXACT []
xref: Wikipedia:Posttranslational_modification
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0043688
name: conversion of aspartyl-tRNA to asparaginyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA." [GOC:jsg, PMID:9789001]
comment: Note that this process has been observed in some archaeal and bacterial species.
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0043691
name: reverse cholesterol transport
namespace: biological_process
def: "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809]
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0043692
name: monoterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [Wikipedia:Monoterpene]
synonym: "monoterpene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0043693
name: monoterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [Wikipedia:Monoterpene]
synonym: "monoterpene biosynthesis" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0043694
name: monoterpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [PMID:25076942]
synonym: "monoterpene catabolism" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0043695
name: detection of pheromone
namespace: biological_process
def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0019236 ! response to pheromone

[Term]
id: GO:0043696
name: dedifferentiation
namespace: biological_process
def: "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg]
xref: Wikipedia:Cellular_differentiation#Dedifferentiation
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0043697
name: cell dedifferentiation
namespace: biological_process
def: "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg]
comment: Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.
is_a: GO:0043696 ! dedifferentiation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0043698
name: iridosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh]
synonym: "reflecting platelet" EXACT []
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043699
name: leucosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh]
synonym: "refractosome" EXACT []
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043700
name: pterinosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043701
name: cyanosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh]
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043702
name: carotenoid vesicle
namespace: cellular_component
def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0043703
name: photoreceptor cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]
is_a: GO:0048664 ! neuron fate determination
relationship: part_of GO:0046552 ! photoreceptor cell fate commitment

[Term]
id: GO:0043704
name: photoreceptor cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0046552 ! photoreceptor cell fate commitment

[Term]
id: GO:0043705
name: cyanophycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl]
synonym: "cyanophycin metabolism" EXACT []
synonym: "multi-L-arginyl-poly(L-aspartic acid) metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0043707
name: cell adhesion involved in single-species biofilm formation in or on host organism
namespace: biological_process
def: "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species." [GOC:jl]
synonym: "cell adhesion during single-species biofilm formation in or on host organism" RELATED [GOC:dph]
is_a: GO:0043709 ! cell adhesion involved in single-species biofilm formation
relationship: part_of GO:0044407 ! single-species biofilm formation in or on host organism

[Term]
id: GO:0043708
name: cell adhesion involved in biofilm formation
namespace: biological_process
def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm." [GOC:dph, GOC:jl, GOC:tb]
synonym: "cell adhesion during biofilm formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0090605 ! submerged biofilm formation

[Term]
id: GO:0043709
name: cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:dph, GOC:jl, GOC:tb]
synonym: "cell adhesion during single-species biofilm formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043708 ! cell adhesion involved in biofilm formation
relationship: part_of GO:0090609 ! single-species submerged biofilm formation

[Term]
id: GO:0043710
name: cell adhesion involved in multi-species biofilm formation
namespace: biological_process
def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species." [GOC:dph, GOC:jl, GOC:tb]
synonym: "cell adhesion during multi-species biofilm formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043708 ! cell adhesion involved in biofilm formation
relationship: part_of GO:0044399 ! multi-species biofilm formation

[Term]
id: GO:0043711
name: pilus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl]
comment: Note that this term should not be used for direct annotation. Please use one of the children, GO:0009297 ; pilus assembly or GO:0043108 ; pilus retraction.
subset: gocheck_do_not_annotate
synonym: "pilus organisation" EXACT [GOC:mah]
synonym: "pilus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0043712
name: 2-hydroxyisocaproate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate." [PMID:16957230]
synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT []
synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT []
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043713
name: (R)-2-hydroxyisocaproate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043714
name: (R)-citramalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346, RHEA:19045]
synonym: "citramalate synthase" BROAD []
xref: EC:2.3.3.21
xref: MetaCyc:RXN-7743
xref: RHEA:19045
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0043715
name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P." [MetaCyc:R82-RXN]
comment: This function is part of the process of methionine salvage.
synonym: "DK-MTP-1-P enolase activity" EXACT []
synonym: "E-1" RELATED []
synonym: "MasA" RELATED []
synonym: "mtnW" RELATED []
xref: EC:5.3.2.5
xref: MetaCyc:R82-RXN
xref: RHEA:18769
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0043716
name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate." [RHEA:14481]
synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXACT [MetaCyc:R83-RXN]
synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT []
xref: EC:3.1.3.87
xref: KEGG_REACTION:R07394
xref: MetaCyc:R83-RXN
xref: RHEA:14481
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043717
name: 2-hydroxyglutaryl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA." [MetaCyc:RXN-1083]
synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT []
xref: MetaCyc:RXN-1083
xref: RHEA:42448
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043718
name: 2-hydroxymethylglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD+ = 2-formylglutarate + H+ + NADH." [EC:1.1.1.291, RHEA:15505]
synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.291]
synonym: "HgD" EXACT []
xref: EC:1.1.1.291
xref: KEGG_REACTION:R07985
xref: MetaCyc:1.1.1.291-RXN
xref: RHEA:15505
xref: Wikipedia:2-hydroxymethylglutarate_dehydrogenase
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043719
name: obsolete 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O." [GOC:curators]
comment: The reason for obsoletion is that it more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0008682

[Term]
id: GO:0043720
name: 3-keto-5-aminohexanoate cleavage activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [MetaCyc:R125-RXN, PMID:13064]
synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT []
xref: MetaCyc:R125-RXN
xref: RHEA:31555
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0043721
name: 4-hydroxybutanoyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O." [EC:4.2.1.120]
synonym: "4-hydroxybutanoyl-CoA hydro-lyase" EXACT []
synonym: "4-hydroxybutyryl-CoA dehydratase activity" EXACT []
synonym: "gamma-hydroxybutanoyl-CoA dehydratase activity" EXACT []
synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT []
xref: EC:4.2.1.120
xref: KEGG_REACTION:R05337
xref: MetaCyc:RXN-8890
xref: RHEA:26530
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043722
name: 4-hydroxyphenylacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-cresol + CO2." [EC:4.1.1.83, RHEA:22732]
synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" RELATED [EC:4.1.1.83]
synonym: "4-Hpd activity" RELATED [EC:4.1.1.83]
synonym: "4-hydroxyphenylacetate carboxy-lyase activity" RELATED [EC:4.1.1.83]
synonym: "p-Hpd activity" RELATED [EC:4.1.1.83]
synonym: "p-hydroxyphenylacetate decarboxylase activity" RELATED [EC:4.1.1.83]
xref: EC:4.1.1.83
xref: KEGG_REACTION:R07312
xref: MetaCyc:4.1.1.83-RXN
xref: RHEA:22732
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0043723
name: obsolete 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
namespace: molecular_function
alt_id: GO:0017173
def: "OBSOLETE. Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia." [MetaCyc:RXN-10058, PMID:11889103]
comment: The reason for obsoletion is that this term represents the same function as diaminohydroxyphosphoribosylaminopyrimidine deaminase activity.
synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT [MetaCyc:YOL066C-MONOMER]
synonym: "DRAP deaminase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008835

[Term]
id: GO:0043724
name: 2-keto-3-deoxygalactonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170]
synonym: "KDGal aldolase activity" EXACT []
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043726
name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
namespace: molecular_function
alt_id: GO:0019173
def: "Catalysis of the reaction: 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate." [GOC:jl]
synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah]
xref: EC:3.1.3.104
xref: MetaCyc:RIBOPHOSPHAT-RXN
xref: RHEA:25197
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043727
name: obsolete 5-amino-4-imidazole carboxylate lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl]
comment: This term was obsoleted because it represents the same reaction as phosphoribosylaminoimidazole carboxylase activity : GO:0004638.
is_obsolete: true
replaced_by: GO:0004638

[Term]
id: GO:0043728
name: obsolete 2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0043729
name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+." [RHEA:27282]
xref: EC:3.5.1.102
xref: RHEA:27282
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043730
name: 5-ureido-4-imidazole carboxylate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl]
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0043731
name: 6-hydroxynicotinate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591]
xref: EC:1.14.13.114
xref: MetaCyc:RXN-7573
xref: RHEA:27333
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043732
name: 6-hydroxynicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2." [EC:1.17.3.3, RHEA:22808]
synonym: "6-hydroxynicotinate hydroxylase activity" RELATED [EC:1.17.3.3]
synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" RELATED [EC:1.17.3.3]
synonym: "6-hydroxynicotinic acid dehydrogenase activity" RELATED [EC:1.17.3.3]
synonym: "6-hydroxynicotinic acid hydroxylase activity" RELATED [EC:1.17.3.3]
xref: EC:1.17.3.3
xref: KEGG_REACTION:R07221
xref: MetaCyc:RXN-7585
xref: RHEA:22808
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0043733
name: DNA-3-methylbase glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site." [PMID:10777493, PMID:14517230]
synonym: "DNA-3-methyladenine glycosylase III" RELATED []
synonym: "Mag III" NARROW []
synonym: "MagIII" NARROW []
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0043734
name: obsolete DNA-N1-methyladenine dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde." [PMID:19786499]
comment: This term was obsoleted because it represents a specific substrate of oxidative DNA demethylase activity ; GO:0035516.
synonym: "AlkB" NARROW []
synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW []
is_obsolete: true
replaced_by: GO:0035516

[Term]
id: GO:0043736
name: obsolete DNA-3-methyladenine glycosylase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [PMID:10375529]
comment: This term was made obsolete because it represents an enzyme with four different activities.
synonym: "DNA-3-methyladenine glycosylase IV activity" EXACT []
synonym: "Mpg II" NARROW []
synonym: "MpgII" NARROW []
is_obsolete: true
consider: GO:0008725
consider: GO:0043916
consider: GO:0052821
consider: GO:0052822

[Term]
id: GO:0043737
name: deoxyribonuclease V activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7]
synonym: "DNase V activity" RELATED [EC:3.1.21.7]
synonym: "endodeoxyribonuclease V" EXACT []
synonym: "endonuclease V activity" BROAD [EC:3.1.21.7]
synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7]
xref: EC:3.1.21.7
xref: MetaCyc:3.1.21.7-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0043738
name: reduced coenzyme F420 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420." [RHEA:54752]
synonym: "1,5-dihydrocoenzyme F420 dehydrogenase activity" EXACT [CHEBI:15823]
synonym: "F420H2 dehydrogenase activity" EXACT []
xref: EC:1.5.98.3
xref: MetaCyc:RXN-8106
xref: RHEA:54752
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0043739
name: G/U mismatch-specific uracil-DNA glycosylase activity
namespace: molecular_function
def: "Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site." [EC:3.2.2.28, PMID:24739389]
synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT []
synonym: "MUG" EXACT []
synonym: "uracil mismatch repair protein" BROAD []
is_a: GO:0004844 ! uracil DNA N-glycosylase activity
is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0043740
name: GTP cyclohydrolase IIa activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H+ + 2 phosphate." [EC:3.5.4.29, RHEA:22468]
synonym: "GTP 8,9-dihydrolase (phosphate-forming)" RELATED [EC:3.5.4.29]
synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT []
synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29]
xref: EC:3.5.4.29
xref: KEGG_REACTION:R07306
xref: MetaCyc:RXN-10055
xref: RHEA:22468
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0043741
name: alpha-aminoadipate acetyltransferase activity
namespace: molecular_function
alt_id: GO:0043869
def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [PMID:10613839, PMID:12925802, PMID:29053735]
synonym: "L-2-aminoadipate N-acetyltransferase activity" RELATED []
xref: MetaCyc:RXN-5181
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0043743
name: LPPG:FO 2-phospho-L-lactate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [PMID:11888293]
xref: EC:2.7.8.28
xref: RHEA:27510
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043744
name: N2-acetyl-L-aminoadipate kinase activity
namespace: molecular_function
alt_id: GO:0043868
def: "Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate." [PMID:25392000, PMID:26966182, RHEA:41944]
synonym: "[LysW]-aminoadipate kinase" RELATED []
synonym: "acetylaminoadipate kinase activity" EXACT []
synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT []
synonym: "N-acetylaminoadipate kinase activity" EXACT []
xref: MetaCyc:RXN-5182
xref: RHEA:41944
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0043745
name: obsolete N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449]
comment: This term was obsoleted because there is no evidence that it exists.
is_obsolete: true

[Term]
id: GO:0043746
name: obsolete N2-acetyl-L-lysine aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450]
comment: This term was obsoleted because there is no evidence that it exists.
synonym: "N-acetyl-lysine aminotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043747
name: obsolete N2-acetyl-L-lysine deacetylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this reaction exists.
synonym: "N-acetyl-lysine deacetylase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043748
name: O-succinylbenzoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [PMID:8335646]
xref: EC:4.2.1.113
xref: RHEA:10196
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043749
name: obsolete phenol, water dikinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "ATP:phenol:water phosphotransferase activity" EXACT []
synonym: "phenol:water dikinase activity" EXACT []
synonym: "phenylphosphate synthase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043750
name: phosphatidylinositol alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.345]
synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT []
synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT []
synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT []
synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT []
synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT []
synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.345
xref: MetaCyc:2.4.1.57-RXN
xref: RHEA:47368
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0043751
name: polyphosphate:AMP phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [PMID:11237733]
synonym: "PAP" EXACT []
synonym: "PPT" BROAD []
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0043752
name: adenosylcobinamide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156]
synonym: "adenosylcobinamide kinase (ATP-specific) activity" NARROW []
synonym: "adenosylcobinamide kinase (GTP-specific) activity" NARROW []
synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD []
synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD []
synonym: "cobinamide kinase activity" EXACT []
synonym: "CobU" RELATED []
synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT []
xref: EC:2.7.1.156
xref: MetaCyc:2.7.1.156-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043754
name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
namespace: molecular_function
alt_id: GO:0004147
def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [RHEA:18865]
synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" RELATED [EC:2.3.1.168]
synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" RELATED [EC:2.3.1.168]
synonym: "dihydrolipoamide branched chain acyltransferase activity" EXACT []
synonym: "dihydrolipoamide branched chain transacylase activity" EXACT []
synonym: "dihydrolipoyl transacylase activity" RELATED [EC:2.3.1.168]
synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT []
xref: EC:2.3.1.168
xref: MetaCyc:2.3.1.168-RXN
xref: RHEA:18865
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0043755
name: alpha-ribazole phosphatase activity
namespace: molecular_function
alt_id: GO:0019175
def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate." [RHEA:24456]
synonym: "alpha-ribazole-5'-P phosphatase activity" EXACT []
synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT []
synonym: "CobC" RELATED []
xref: EC:3.1.3.73
xref: KEGG_REACTION:R04594
xref: MetaCyc:RXN-16788
xref: RHEA:24456
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043756
name: adenosylcobinamide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide + H2O = (R)-1-aminopropan-2-ol + adenosylcobyrate." [EC:3.5.1.90, RHEA:23504]
synonym: "adenosylcobinamide amidohydrolase activity" RELATED [EC:3.5.1.90]
synonym: "AdoCbi amidohydrolase activity" RELATED [EC:3.5.1.90]
synonym: "AdoCbi hydrolase activity" RELATED [EC:3.5.1.90]
synonym: "CbiZ" RELATED []
xref: EC:3.5.1.90
xref: KEGG_REACTION:R05226
xref: MetaCyc:R346-RXN
xref: RHEA:23504
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043757
name: adenosylcobinamide-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10]
synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT []
synonym: "AdoCbi-P synthase activity" RELATED [EC:6.3.1.10]
synonym: "CbiB" RELATED []
xref: EC:6.3.1.10
xref: MetaCyc:RXN-6261
xref: RHEA:21896
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0043758
name: acetate-CoA ligase (ADP-forming) activity
namespace: molecular_function
alt_id: GO:0043762
def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [RHEA:15081]
synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13]
synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT []
synonym: "acetate:CoA ligase (ADP-forming)" RELATED []
synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT []
synonym: "acetyl-CoA synthetase (ADP-forming) activity" RELATED [EC:6.2.1.13]
synonym: "aryl-CoA synthetase (ADP-forming) activity" RELATED []
xref: EC:6.2.1.13
xref: MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN
xref: RHEA:15081
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043759
name: 2-methylbutanoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = AMP + diphosphate + 2-methylbutanoyl-CoA." [RHEA:46180]
synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT []
synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT []
synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT []
synonym: "branched-chain acyl-CoA synthetase (ADP-forming) activity" RELATED []
xref: RHEA:46180
is_a: GO:0031955 ! short-chain fatty acid-CoA ligase activity

[Term]
id: GO:0043760
name: acetyldiaminopimelate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [PMID:1906065]
synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT []
synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT []
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043761
name: archaetidylserine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [PMID:12562787]
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT []
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT []
xref: EC:2.7.8.38
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0043763
name: UTP:glucose-1-phosphate uridylyltransferase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl]
synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT []
synonym: "UDP-glucose diphosphorylase regulator activity" EXACT []
synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0043765
name: T/G mismatch-specific endonuclease activity
namespace: molecular_function
def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [PMID:17651368]
synonym: "DNA mismatch endonuclease" BROAD []
synonym: "V.EcoKDcm" RELATED []
synonym: "very short patch repair protein" RELATED []
synonym: "Vsr mismatch endonuclease" RELATED []
is_a: GO:0004520 ! DNA endonuclease activity

[Term]
id: GO:0043766
name: Sep-tRNA:Cys-tRNA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate." [PMID:15790858, PMID:16380427, PMID:17110438, RHEA:25686]
synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT []
synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT []
synonym: "SepCysS" RELATED []
xref: EC:2.5.1.73
xref: MetaCyc:RXN-10719
xref: RHEA:25686
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0043767
name: pyrrolysyl-tRNA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)." [PMID:15314242, RHEA:19277]
synonym: "PylRS" EXACT []
synonym: "pyrrolysine-tRNA ligase activity" EXACT []
xref: EC:6.1.1.26
xref: MetaCyc:6.1.1.26-RXN
xref: RHEA:19277
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0043768
name: S-ribosylhomocysteine lyase activity
namespace: molecular_function
alt_id: GO:0019138
def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine." [RHEA:17753]
synonym: "LuxS" RELATED []
synonym: "ribosylhomocysteinase activity" EXACT []
synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21]
synonym: "S-ribosylhomocysteinase activity" EXACT []
xref: EC:4.4.1.21
xref: KEGG_REACTION:R01291
xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN
xref: RHEA:17753
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0043769
name: Tpg-containing telomere binding complex
namespace: cellular_component
def: "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591]
synonym: "telomere complex" BROAD []
is_a: GO:0000782 ! telomere cap complex

[Term]
id: GO:0043770
name: demethylmenaquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H+ + S-adenosyl-L-homocysteine. Reaction substrates can have varying polyprenyl side chain length." [PMID:1444716, PMID:9045837, RHEA:42640]
xref: EC:2.1.1.163
xref: MetaCyc:RXN-11046
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043771
name: cytidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [PMID:211379, RHEA:24674]
synonym: "uridine-cytidine kinase activity" NARROW [EC:2.7.1.48]
xref: EC:2.7.1.213
xref: RHEA:24674
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0043772
name: acyl-phosphate glycerol-3-phosphate acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [PMID:17308305]
synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT []
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0043773
name: coenzyme F420-0 gamma-glutamyl ligase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates." [PMID:17669425]
synonym: "F420-0 gamma-glutamyl ligase activity" EXACT []
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043774
name: coenzyme F420-2 alpha-glutamyl ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [PMID:12909715]
synonym: "F420-2 alpha-glutamyl ligase activity" EXACT []
xref: EC:6.3.2.32
xref: RHEA:42332
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043776
name: cobalt-precorrin-6B C5-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [MetaCyc:RXN-8766]
synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT []
synonym: "precorrin-6 methyltransferase activity" EXACT []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: MetaCyc:RXN-8766
xref: RHEA:36067
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043777
name: cobalt-precorrin-7 C15-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [MetaCyc:RXN-8767]
synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT []
synonym: "precorrin-6 methyltransferase" BROAD []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: MetaCyc:RXN-8767
xref: RHEA:34591
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043778
name: cobalt-precorrin-8 methylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [MetaCyc:RXN-8768]
synonym: "cobalt-precorrin 8 methylmutase activity" EXACT []
synonym: "cobalt-precorrin 8X methylmutase activity" EXACT []
synonym: "cobalt-precorrin-8X methylmutase activity" EXACT []
xref: EC:5.4.99.60
xref: MetaCyc:RXN-8768
xref: RHEA:16209
is_a: GO:0016867 ! intramolecular acyltransferase activity

[Term]
id: GO:0043779
name: cobalt-precorrin-5A acetaldehyde-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+." [RHEA:26281]
synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT []
xref: EC:3.7.1.12
xref: MetaCyc:RXN-8763
xref: RHEA:26281
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0043780
name: cobalt-precorrin-5B C1-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [MetaCyc:RXN-8764]
synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT []
xref: MetaCyc:RXN-8764
xref: RHEA:26285
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043781
name: cobalt-factor II C20-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151]
synonym: "CbiL" NARROW []
synonym: "cobalt-factor II C20 methyltransferase activity" EXACT []
synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" RELATED [EC:2.1.1.151]
synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" RELATED [EC:2.1.1.151]
xref: EC:2.1.1.151
xref: MetaCyc:RXN-8760
xref: RHEA:17997
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043782
name: cobalt-precorrin-3 C17-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [MetaCyc:RXN-8761]
synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT []
synonym: "cobalt-precorrin-3 methylase" BROAD []
synonym: "cobalt-precorrin-3 methyltransferase" BROAD []
synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT []
xref: MetaCyc:RXN-8761
xref: RHEA:26273
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043783
name: obsolete oxidoreductase activity, acting on metal ions, flavin as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "oxidoreductase activity, oxidizing metal ions with flavin as acceptor" RELATED []
synonym: "oxidoreductase activity, reducing metal ions, flavin as acceptor" RELATED []
is_obsolete: true

[Term]
id: GO:0043785
name: cinnamoyl-CoA:phenyllactate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate." [EC:2.8.3.17, RHEA:15601]
synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT []
synonym: "FldA" RELATED []
xref: EC:2.8.3.17
xref: KEGG_REACTION:R07796
xref: MetaCyc:2.8.3.17-RXN
xref: RHEA:15601
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043786
name: cinnamate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [PMID:10849007, RHEA:50944]
xref: RHEA:50944
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043791
name: dimethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [PMID:9874228]
comment: This function is the first step in the pathway of methanogenesis from dimethylamine.
synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT []
synonym: "DMA methyltransferase 1" EXACT []
synonym: "DMAMT 1" EXACT []
synonym: "MT1" BROAD []
synonym: "mtbB1" RELATED []
xref: EC:2.1.1.249
xref: MetaCyc:RXN-8100
xref: RHEA:41175
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043792
name: enamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4." [EC:3.5.2.18, RHEA:17209]
synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT []
xref: EC:3.5.2.18
xref: KEGG_REACTION:R07984
xref: MetaCyc:3.5.2.18-RXN
xref: RHEA:17209
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043793
name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H+ = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate. Both 4-hydroxybenzoate and 4-aminobenzoate may be used as substrates, but only the former is known to be produced by methanogenic archaea." [EC:2.4.2.54, PMID:12142414]
synonym: "beta-RFAP synthase activity" EXACT []
xref: EC:2.4.2.54
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0043794
name: formate dehydrogenase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + 2 H+ + oxidized coenzyme F420-(gamma-L-Glu)(n) = CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)." [PMID:3801411, RHEA:42764]
synonym: "formate dehydrogenase (F420) activity" EXACT []
xref: EC:1.17.98.3
xref: MetaCyc:RXN-15617
xref: RHEA:42764
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0043795
name: glyceraldehyde oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+." [PMID:10095793, RHEA:36047]
xref: EC:1.2.99.8
xref: RHEA:36047
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0043796
name: glyceraldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [RHEA:40163]
synonym: "glyceraldehyde dehydrogenase (NADP) activity" EXACT []
xref: EC:1.2.1.89
xref: RHEA:40163
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity

[Term]
id: GO:0043797
name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [PMID:11265456, PMID:7721730, RHEA:24148]
synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT []
synonym: "GAPOR" RELATED []
synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" RELATED [EC:1.2.7.6]
synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" RELATED [EC:1.2.7.6]
xref: EC:1.2.7.6
xref: MetaCyc:1.2.7.6-RXN
xref: RHEA:24148
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043798
name: glycerate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [PMID:14413719, RHEA:27377]
synonym: "D-glycerate 2-kinase activity" EXACT []
synonym: "glycerate kinase" BROAD []
xref: EC:2.7.1.165
xref: MetaCyc:GKI-RXN
xref: RHEA:27377
is_a: GO:0016301 ! kinase activity
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0043799
name: glycine oxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide." [EC:1.4.3.19]
synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT []
xref: EC:1.4.3.19
is_a: GO:0052595 ! aliphatic amine oxidase activity

[Term]
id: GO:0043800
name: hexulose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [MetaCyc:R12-RXN, PMID:11839305]
synonym: "HUMPI" EXACT []
xref: EC:5.3.1.27
xref: MetaCyc:R12-RXN
xref: RHEA:25900
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0043801
name: hexulose-6-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [PMID:16075199]
xref: EC:4.1.2.43
xref: MetaCyc:R10-RXN
xref: RHEA:25201
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043802
name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H2O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H+ + hydrogenobyrinate a,c-diamide + 2 phosphate." [EC:6.3.5.9, RHEA:12544]
synonym: "CobB" RELATED []
synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT []
synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT []
xref: EC:6.3.5.9
xref: KEGG_REACTION:R05224
xref: MetaCyc:R341-RXN
xref: RHEA:12544
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0043803
name: hydroxyneurosporene-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + spheroidene." [PMID:12664193, PMID:12770713, PMID:7358679, RHEA:30903]
synonym: "1-HO-carotenoid methylase" RELATED [EC:2.1.1.210]
synonym: "1-hydroxycarotenoid methylase" RELATED [EC:2.1.1.210]
synonym: "1-hydroxycarotenoid O-methylase" RELATED [EC:2.1.1.210]
synonym: "demethylspheroidene O-methyltransferase" RELATED [EC:2.1.1.210]
xref: EC:2.1.1.210
xref: RHEA:30903
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043804
name: imidazolone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one." [PMID:27286964, RHEA:24935]
comment: Note that this reaction can occur spontaneously (see RHEA:24937).
xref: RHEA:24935
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043805
name: indolepyruvate ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8]
synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" RELATED [EC:1.2.7.8]
synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" RELATED [EC:1.2.7.8]
synonym: "indolepyruvate oxidoreductase activity" RELATED [EC:1.2.7.8]
synonym: "IOR" RELATED []
xref: EC:1.2.7.8
xref: MetaCyc:1.2.7.8-RXN
xref: RHEA:12645
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043806
name: obsolete keto acid formate lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN]
comment: This term was obsoleted because it represents the same function as 2-ketobutyrate formate-lyase activity ; GO:0043875.
synonym: "keto-acid formate acetyltransferase" BROAD []
synonym: "keto-acid formate lyase activity" EXACT []
synonym: "keto-acid formate-lyase activity" EXACT []
is_obsolete: true
replaced_by: GO:0043875

[Term]
id: GO:0043807
name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7]
synonym: "2-ketoisovalerate ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "2-oxoisovalerate ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" RELATED [EC:1.2.7.7]
synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT []
synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "keto-valine-ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.7]
synonym: "ketoisovalerate ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "ketoisovalerate oxidoreductase activity" RELATED [EC:1.2.7.7]
synonym: "VOR" RELATED []
xref: EC:1.2.7.7
xref: MetaCyc:1.2.7.7-RXN
xref: RHEA:11712
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043808
name: lyso-ornithine lipid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]." [PMID:15341653]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0043810
name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids." [PMID:15341653, RHEA:20633]
synonym: "L-ornithine N(alpha)-acyltransferase" EXACT []
synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT []
xref: EC:2.3.2.30
xref: RHEA:20633
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0043811
name: phosphate:acyl-[acyl carrier protein] acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]." [RHEA:42292]
xref: EC:2.3.1.274
xref: RHEA:42292
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0043812
name: phosphatidylinositol-4-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate." [PMID:10224048, RHEA:55652]
synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT []
xref: RHEA:55652
is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity
is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity

[Term]
id: GO:0043813
name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [PMID:10806194, PMID:16607019, RHEA:32955]
synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT []
xref: Reactome:R-HSA-1675836 "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane"
xref: Reactome:R-HSA-1676005 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane"
xref: Reactome:R-HSA-1676020 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane"
xref: Reactome:R-HSA-1676174 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane"
xref: RHEA:32955
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity
is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity

[Term]
id: GO:0043814
name: phospholactate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [PMID:18260642, RHEA:63424]
xref: EC:2.7.7.68
xref: RHEA:63424
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0043815
name: phosphoribosylglycinamide formyltransferase 2 activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate + N1-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H+ + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide + phosphate." [PMID:8117714, RHEA:24829]
synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT []
synonym: "formate-dependent GAR transformylase activity" EXACT []
synonym: "GAR transformylase 2" RELATED []
synonym: "GART 2" RELATED []
xref: EC:6.3.1.21
xref: MetaCyc:GARTRANSFORMYL2-RXN
xref: RHEA:24829
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0043816
name: phosphoserine-tRNA(Cys) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)." [PMID:17110438, RHEA:25678]
synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT []
synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT []
synonym: "phosphoserine-tRNACys ligase activity" EXACT []
synonym: "SepRS" RELATED []
xref: EC:6.1.1.27
xref: RHEA:25678
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0043817
name: phosphosulfolactate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite." [EC:4.4.1.19, RHEA:22784]
synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" RELATED [EC:4.4.1.19]
synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT []
synonym: "(2R)-phospho-3-sulfolactate synthase activity" RELATED [EC:4.4.1.19]
synonym: "PSL synthase activity" RELATED [EC:4.4.1.19]
xref: EC:4.4.1.19
xref: KEGG_REACTION:R07476
xref: MetaCyc:4.4.1.19-RXN
xref: RHEA:22784
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0043818
name: precorrin-3B synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + precorrin-3A = H2O + NAD+ + precorrin-3B." [EC:1.14.13.83, RHEA:17293]
synonym: "CobG" RELATED []
synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT []
synonym: "precorrin-3X synthase activity" RELATED [EC:1.14.13.83]
xref: EC:1.14.13.83
xref: KEGG_REACTION:R05217
xref: MetaCyc:R321-RXN
xref: RHEA:17293
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043819
name: precorrin-6A synthase (deacetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + H2O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H+ + precorrin-6X." [EC:2.1.1.152, RHEA:18261]
synonym: "CobF" RELATED []
synonym: "precorrin-6X synthase (deacetylating) activity" RELATED [EC:2.1.1.152]
synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT []
xref: EC:2.1.1.152
xref: KEGG_REACTION:R05219
xref: MetaCyc:R322-RXN
xref: RHEA:18261
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043820
name: obsolete propionyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323]
comment: This term was obsoleted because it represents the same raection as acryloyl-CoA reductase (NADH) activity ; GO:0043958.
is_obsolete: true
replaced_by: GO:0043958

[Term]
id: GO:0043821
name: propionyl-CoA:succinate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [PMID:10769117]
synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT []
synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT []
xref: MetaCyc:RXN0-268
xref: RHEA:28010
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043822
name: ribonuclease M5 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [PMID:402365]
synonym: "5S ribosomal maturation nuclease activity" RELATED [EC:3.1.26.8]
synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT []
synonym: "RNase M5 activity" RELATED [EC:3.1.26.8]
xref: EC:3.1.26.8
xref: MetaCyc:3.1.26.8-RXN
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0043823
name: spheroidene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [PMID:16086104, PMID:16158287]
xref: EC:1.14.15.9
xref: MetaCyc:RXN-10670
xref: RHEA:33027
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043824
name: succinylglutamate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H2O + NAD+ = N-succinyl-L-glutamate + 2 H+ + NADH." [EC:1.2.1.71, RHEA:10812]
synonym: "AruD" RELATED []
synonym: "AstD" RELATED []
synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.71]
synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.71]
synonym: "SGSD" RELATED []
synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT []
synonym: "succinylglutamic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.71]
xref: EC:1.2.1.71
xref: KEGG_REACTION:R05049
xref: MetaCyc:SUCCGLUALDDEHYD-RXN
xref: RHEA:10812
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043825
name: succinylornithine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, RHEA:16953]
synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" RELATED [EC:2.6.1.81]
synonym: "AstC" RELATED []
synonym: "N(2)-succinylornithine 5-aminotransferase activity" RELATED [EC:2.6.1.81]
synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT []
synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT []
synonym: "SOAT" RELATED []
synonym: "succinyl ornithine transaminase activity" EXACT []
synonym: "succinyl-ornithine transaminase activity" RELATED [EC:2.6.1.81]
synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81]
xref: EC:2.6.1.81
xref: KEGG_REACTION:R04217
xref: MetaCyc:SUCCORNTRANSAM-RXN
xref: RHEA:16953
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043826
name: obsolete sulfur oxygenase reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+." [PMID:1522063]
comment: This term was obsoleted because it represents the same activity as sulfur oxygenase/reductase activity ; GO:0033755.
synonym: "SOR" RELATED []
synonym: "sulphur oxygenase reductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0033755

[Term]
id: GO:0043827
name: tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine57/adenosine58 in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N1-methyladenosine57/N1-methyladenosine58 in tRNA + 2 S-adenosyl-L-homocysteine." [PMID:14739239, PMID:20483913, RHEA:41740]
synonym: "tRNA (adenine(57)-N(1))/(adenine(58)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA (adenine(57)-N1-)/(adenine(58)-N1-)-methyltransferase activity" EXACT []
synonym: "tRNA (adenine(57)-N1-/adenine(58)-N1-)-methyltransferase activity" EXACT []
synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT []
synonym: "tRNA (adenine-57, 58-N(1)-) methyltransferase activity" EXACT []
synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT []
xref: EC:2.1.1.219
xref: RHEA:41740
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0043828
name: tRNA 2-selenouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [PMID:14594807, RHEA:42716]
xref: EC:2.9.1.3
xref: MetaCyc:RXN0-2281
xref: RHEA:42716
is_a: GO:0016785 ! selenotransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0043829
name: tRNA-specific adenosine-37 deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [PMID:8915538, PMID:9707437, RHEA:50968]
synonym: "TAD1" RELATED []
synonym: "tRNA(Ala)-A37 deaminase activity" EXACT []
synonym: "tRNA-specific adenosine deaminase 1" EXACT []
xref: EC:3.5.4.34
xref: RHEA:50968
is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity

[Term]
id: GO:0043830
name: obsolete thiol-driven fumarate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [PMID:2509466]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0043831
name: thiosulfate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate." [RHEA:10936]
synonym: "DoxA" RELATED []
synonym: "DoxD" RELATED []
synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" RELATED [EC:1.8.5.2]
synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" RELATED [EC:1.8.5.2]
synonym: "thiosulfate:quinone oxidoreductase activity" RELATED [EC:1.8.5.2]
synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT []
synonym: "thiosulphate:quinone oxidoreductase activity" EXACT []
synonym: "TQO" RELATED []
xref: EC:1.8.5.2
xref: KEGG_REACTION:R07177
xref: MetaCyc:1.8.5.2-RXN
xref: RHEA:10936
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0043833
name: [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [RHEA:18773]
comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine.
synonym: "methylamine-specific methylcobalamin:coenzyme M methyltransferase activity" EXACT []
synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT []
synonym: "methylcobamide:coenzyme M methyltransferase activity" BROAD []
synonym: "methylcobamide:CoM methyltransferase activity" BROAD []
synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
synonym: "MT2-A" BROAD [EC:2.1.1.247]
xref: EC:2.1.1.247
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043834
name: trimethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Co(I)-[trimethylamine-specific corrinoid protein] + H+ + trimethylamine = dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]." [PMID:9006042, RHEA:39287]
comment: This function is the first step in the pathway of methanogenesis from trimethylamine.
synonym: "MT1" BROAD []
synonym: "mttB1" RELATED []
synonym: "TMA methyltransferase 1" EXACT []
synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT []
xref: EC:2.1.1.250
xref: MetaCyc:RXN-8102
xref: RHEA:39287
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043835
name: obsolete uracil/thymine dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [GOC:curators]
comment: This term was made obsolete because it represents two separate molecular functions.
synonym: "uracil/thymine dehydrogenase activity" EXACT []
synonym: "uracil:acceptor oxidoreductase activity" NARROW []
is_obsolete: true
consider: GO:0050383
consider: GO:0052620

[Term]
id: GO:0043836
name: xanthine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [MetaCyc:R127-RXN, PMID:13278326]
synonym: "xanthinase activity" EXACT []
xref: MetaCyc:R127-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043837
name: valine dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [PMID:10612726, PMID:2803248]
synonym: "ValDH" RELATED []
synonym: "valine dehydrogenase (NAD) activity" EXACT []
xref: EC:1.4.1.23
xref: RHEA:30763
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043838
name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [PMID:15795227]
comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid.
synonym: "EptB" RELATED []
synonym: "phosphoethanolamine transferase" BROAD []
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0043839
name: lipid A phosphate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A." [PMID:15994324]
synonym: "lipid A 1-phosphomethyltransferase activity" EXACT []
synonym: "lipid A methyltransferase" BROAD []
synonym: "lipid A phosphomethyltransferase activity" EXACT []
synonym: "LmtA" RELATED []
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0043840
name: obsolete branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [PMID:12670965]
comment: This term was obsoleted because it represents a specific substrate of branched-chain-amino-acid transaminase activity ; GO:0004084.
synonym: "BCAT" RELATED []
synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT []
synonym: "branched-chain amino acid aminotransferase" BROAD []
synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004084

[Term]
id: GO:0043841
name: obsolete (S)-lactate 2-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [PMID:11535063]
comment: This term was obsoleted because there is no evidence that this activity exists, and the pathway uses phosphoenolpyruvate, rather than 2-phospho-L-lactate (see PMID:30952857).
synonym: "lactate 2-kinase activity" EXACT []
is_obsolete: true
replaced_by: GO:0043814

[Term]
id: GO:0043842
name: Kdo transferase activity
namespace: molecular_function
def: "Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [PMID:1577828, PMID:2033061, PMID:9195966]
synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT []
synonym: "kdtA" RELATED []
synonym: "WaaA" RELATED []
is_a: GO:0016757 ! glycosyltransferase activity

[Term]
id: GO:0043843
name: ADP-specific glucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147]
synonym: "ADP-dependent glucokinase activity" RELATED [EC:2.7.1.147]
synonym: "ADP:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.147]
xref: EC:2.7.1.147
xref: Reactome:R-HSA-5696021 "ADPGK:Mg2+ phosphorylates Glc to G6P"
xref: RHEA:11460
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043844
name: ADP-specific phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146]
synonym: "ADP-6-phosphofructokinase activity" RELATED [EC:2.7.1.146]
synonym: "ADP-dependent phosphofructokinase activity" RELATED [EC:2.7.1.146]
synonym: "ADP-Pfk activity" RELATED [EC:2.7.1.146]
synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.146]
xref: EC:2.7.1.146
xref: RHEA:20105
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043845
name: DNA polymerase III, proofreading complex
namespace: cellular_component
def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [PMID:16973612, Wikipedia:Pol_III]
synonym: "DNA polymerase III, proof-reading complex" EXACT []
synonym: "DNA polymerase III, proof-reading subcomplex" EXACT []
synonym: "DNA polymerase III, proofreading subcomplex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0044776 ! DNA polymerase III, core complex

[Term]
id: GO:0043846
name: DNA polymerase III, clamp loader complex
namespace: cellular_component
def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977]
synonym: "clamp loader complex" BROAD []
synonym: "DNA polymerase III, DnaX complex" EXACT []
synonym: "DNA polymerase III, DnaX subcomplex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0009360 ! DNA polymerase III complex

[Term]
id: GO:0043847
name: DNA polymerase III, clamp loader chi/psi subcomplex
namespace: cellular_component
def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [PMID:12940977]
synonym: "DNA polymerase III, DnaX complex, chi/psi subcomplex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043846 ! DNA polymerase III, clamp loader complex

[Term]
id: GO:0043848
name: obsolete excinuclease cho activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage." [PMID:11818552]
comment: This term was obsoleted because it represented a gene product.
synonym: "cho" RELATED []
synonym: "endonuclease cho" EXACT []
synonym: "uvrc homolog protein" RELATED []
is_obsolete: true

[Term]
id: GO:0043849
name: Ras palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [PMID:16000296]
synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED []
synonym: "ERF2" RELATED []
synonym: "palmitoyltransferase ERF2" RELATED []
synonym: "Ras protein acyltransferase activity" EXACT []
is_a: GO:0019706 ! protein-cysteine S-palmitoyltransferase activity

[Term]
id: GO:0043850
name: RecFOR complex
namespace: cellular_component
def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [PMID:12769856]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0043852
name: monomethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3." [PMID:9195968]
comment: This function is the first step in the pathway of methanogenesis from monomethylamine.
synonym: "MMAMT" RELATED []
synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT []
synonym: "MtmB" RELATED []
xref: EC:2.1.1.248
xref: MetaCyc:RXN-8098
xref: RHEA:26059
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043853
name: methanol-CoM methyltransferase complex
namespace: cellular_component
def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [PMID:9363780]
synonym: "methanol-coenzyme M methyltransferase complex" EXACT []
synonym: "methanol: coenzyme M methyltransferase complex" EXACT []
synonym: "methanol: CoM methyltransferase complex" EXACT []
synonym: "methanol:coenzyme M methyltransferase complex" EXACT []
synonym: "methanol:CoM methyltransferase complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0043854
name: cyclic nucleotide-gated mechanosensitive monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, PMID:22206667]
synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT []
synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT []
synonym: "cyclic nucleotide-gated mechanosensitive ion channel activity" BROAD []
synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT []
synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED []
synonym: "MscS" RELATED []
synonym: "small conductance mechanosensitive ion channel" EXACT []
is_a: GO:0008381 ! mechanosensitive monoatomic ion channel activity

[Term]
id: GO:0043855
name: cyclic nucleotide-activated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl]
synonym: "cyclic nucleotide activated ion channel activity" EXACT []
synonym: "cyclic nucleotide gated ion channel activity" EXACT []
synonym: "cyclic nucleotide-gated ion channel activity" BROAD []
synonym: "cyclic nucleotide-gated monoatomic ion channel activity" EXACT []
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0043856
name: anti-sigma factor antagonist activity
namespace: molecular_function
def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, GOC:txnOH, PMID:15576799]
synonym: "anti-anti-sigma factor activity" EXACT []
is_a: GO:0140110 ! transcription regulator activity

[Term]
id: GO:0043857
name: N-acetylornithine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H+ + phosphate." [EC:2.1.3.9, RHEA:18609]
synonym: "acetylornithine transcarbamylase activity" EXACT []
synonym: "AOTC" RELATED []
synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.9]
synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.9]
synonym: "N-acetylornithine transcarbamylase activity" EXACT []
xref: EC:2.1.3.9
xref: KEGG_REACTION:R07245
xref: MetaCyc:2.1.3.9-RXN
xref: RHEA:18609
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0043858
name: arginine:ornithine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979, RHEA:34991]
synonym: "ArcD" RELATED []
synonym: "arginine-ornithine antiporter activity" EXACT []
synonym: "arginine/ornithine antiporter activity" EXACT []
xref: RHEA:34991
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0043859
name: obsolete cyanophycinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200]
comment: This term was made obsolete because it represents a gene product.
synonym: "cyanophycinase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008236

[Term]
id: GO:0043860
name: cyanophycin synthetase activity
namespace: molecular_function
def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [GOC:jl]
synonym: "cphA" RELATED []
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043861
name: agmatine:putrescine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272]
synonym: "agmatine-putrescine antiporter activity" EXACT []
synonym: "agmatine/putrescine antiporter activity" EXACT []
is_a: GO:0015297 ! antiporter activity
is_a: GO:0015489 ! putrescine transmembrane transporter activity

[Term]
id: GO:0043862
name: arginine:agmatine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215]
synonym: "AdiC" RELATED []
synonym: "arginine-agmatine antiporter activity" EXACT []
synonym: "arginine-agmatine exchange transporter activity" EXACT []
synonym: "arginine/agmatine antiporter activity" EXACT []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0043863
name: 4-hydroxy-2-ketopimelate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN]
synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT []
synonym: "HHED aldolase activity" EXACT []
synonym: "HpaI" RELATED []
synonym: "HpcH" RELATED []
xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN
xref: RHEA:25788
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043864
name: indoleacetamide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: iH2O + indole-3-acetamide = (indol-3-yl)acetate + NH4+. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA." [GOC:jl, RHEA:34371]
synonym: "IaaH" RELATED []
synonym: "IAH" EXACT []
synonym: "indole acetamide hydrolase activity" EXACT []
synonym: "indole-3-acetamide hydrolase activity" EXACT []
synonym: "Tms2" RELATED []
xref: MetaCyc:G-5841
xref: RHEA:34371
is_a: GO:0004040 ! amidase activity

[Term]
id: GO:0043865
name: methionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1990240
def: "Enables the transfer of methionine from one side of a membrane to the other." [GOC:jl]
synonym: "methionine importer" RELATED []
synonym: "methionine importer activity" NARROW []
synonym: "methionine importing activity" NARROW []
synonym: "methionine-importing activity" NARROW []
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0043866
name: adenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10]
synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT []
synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.4.10]
synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT []
xref: EC:1.8.4.10
xref: RHEA:21976
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0043867
name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, PMID:7748953]
synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT []
synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT []
synonym: "TgtA" RELATED []
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0043870
name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [RHEA:41948]
comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway.
synonym: "AGPR" RELATED []
synonym: "ArgC" RELATED []
synonym: "LysY" RELATED []
synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT []
synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT []
synonym: "NAGSA dehydrogenase activity" BROAD []
xref: MetaCyc:RXN-5183
xref: RHEA:41948
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043871
name: delta1-piperideine-6-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [MetaCyc:RXN-8162, PMID:16237033]
comment: This function is part of the pipecolate pathway of lysine catabolism.
synonym: "AmaB" RELATED []
synonym: "PIPOX" RELATED []
xref: MetaCyc:RXN-8162
xref: RHEA:49476
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043872
name: lysine:cadaverine antiporter activity
namespace: molecular_function
alt_id: GO:0015490
alt_id: GO:0015497
def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, TC:2.A.3.2.2]
synonym: "cadaverine transmembrane transporter activity" NARROW []
synonym: "cadaverine:lysine antiporter activity" EXACT []
synonym: "lysine-cadaverine antiporter activity" EXACT []
synonym: "lysine/cadaverine antiporter activity" EXACT []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0043873
name: pyruvate-flavodoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705]
synonym: "NifJ" RELATED []
synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT []
xref: MetaCyc:PYFLAVOXRE-RXN
xref: RHEA:44140
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043874
name: acireductone synthase activity
namespace: molecular_function
def: "Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate." [RHEA:21700]
comment: This activity is involved in the process of methionine salvage.
synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" RELATED [EC:3.1.3.77]
synonym: "E-1" RELATED []
synonym: "E-1 enolase-phosphatase" BROAD []
xref: EC:3.1.3.77
xref: MetaCyc:3.1.3.77-RXN
xref: Reactome:R-HSA-1237129 "Acireductone is created"
xref: RHEA:21700
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043875
name: 2-ketobutyrate formate-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [PMID:9484901, RHEA:28054]
comment: This function is part of an anaerobic pathway for the catabolism of L-threonine.
synonym: "keto-acid formate acetyltransferase" BROAD []
synonym: "KFL" EXACT []
synonym: "TdcE" RELATED []
xref: MetaCyc:KETOBUTFORMLY-RXN
xref: RHEA:28054
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0043876
name: D-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [MetaCyc:4.1.2.42-RXN, PMID:9642221]
synonym: "D-allo-TA" EXACT []
synonym: "D-allo-threonine aldolase activity" EXACT []
synonym: "D-TA" EXACT []
synonym: "DtaAS" RELATED []
synonym: "low-specificity D-threonine aldolase" NARROW []
xref: EC:4.1.2.42
xref: MetaCyc:4.1.2.42-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043877
name: galactosamine-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [PMID:10931310]
comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization.
synonym: "AgaI" RELATED []
synonym: "galactosamine-6-phosphate deaminase activity" EXACT []
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0043878
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334]
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT []
synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT []
xref: MetaCyc:RXN-3443
xref: RHEA:42760
is_a: GO:0120533 ! glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (non-phosphorylating) activity

[Term]
id: GO:0043879
name: glycolate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [GOC:jl]
synonym: "glcA" RELATED []
synonym: "glycolate permease" RELATED []
synonym: "glycolic acid transmembrane transporter activity" EXACT []
synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0043880
name: crotonyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [InterPro:IPR010085, PMID:11162231]
synonym: "CCR" EXACT []
synonym: "crotonyl-coenzyme A reductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043881
name: mesaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937]
comment: This function is part of an alternate glyoxylate cycle for acetate assimilation.
synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT []
synonym: "mch" RELATED []
synonym: "mesaconyl-coenzyme A hydratase activity" EXACT []
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043882
name: malate:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, PMID:10903309]
synonym: "malate Na(+) symporter activity" EXACT []
synonym: "malate-sodium symporter activity" EXACT []
synonym: "malate/sodium cotransporter activity" BROAD []
synonym: "malate/sodium symporter activity" EXACT []
synonym: "malate:Na+ symporter activity" EXACT []
synonym: "malate:sodium cotransporter activity" BROAD []
synonym: "Na(+)-malate symporter activity" EXACT []
synonym: "Na+:malate symporter activity" EXACT []
synonym: "sodium-dependent malate transporter" BROAD []
synonym: "sodium/malate symporter activity" EXACT []
synonym: "sodium:malate symporter activity" EXACT []
xref: RHEA:72295
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity

[Term]
id: GO:0043883
name: malolactic enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + H+ = (S)-lactate + CO2." [PMID:3139053, RHEA:46276]
comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria.
synonym: "MleS" RELATED []
xref: EC:4.1.1.101
xref: MetaCyc:RXN-16819
xref: RHEA:46276
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043884
name: CO-methylating acetyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656]
synonym: "acetyl-CoA synthase activity" BROAD []
synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT []
synonym: "ACS" RELATED [EC:2.3.1.169]
synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT []
xref: EC:2.3.1.169
xref: MetaCyc:ACETYLSYNCLTH-RXN
xref: RHEA:45212
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0043885
name: anaerobic carbon-monoxide dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [RHEA:21040]
synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT []
synonym: "carbon monoxide dehydrogenase activity" BROAD []
synonym: "carbon-monoxide dehydrogenase (ferredoxin) activity" EXACT []
synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4]
synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT []
synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT []
synonym: "CO dehydrogenase activity" EXACT []
synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT []
synonym: "CO-dehydrogenase activity" EXACT []
synonym: "CODH" RELATED []
xref: EC:1.2.7.4
xref: MetaCyc:1.2.7.4-RXN
xref: RHEA:21040
xref: UM-BBD_reactionID:r0652
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043886
name: structural constituent of carboxysome shell
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a carboxysome shell, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO2." [GOC:jl, PMID:28934381]
synonym: "structural constituent of carboxysome" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0043887
name: melibiose:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646]
synonym: "MelB" RELATED []
synonym: "melibiose carrier protein" RELATED []
synonym: "melibiose permease" BROAD []
synonym: "melibiose-Na+ symporter activity" EXACT []
synonym: "melibiose-sodium symporter activity" EXACT []
synonym: "melibiose/Na+ symporter activity" EXACT []
synonym: "melibiose/sodium symporter activity" EXACT []
synonym: "melibiose:Na+ symporter activity" EXACT []
synonym: "Na+ (Li+)/melibiose symporter activity" EXACT []
synonym: "Na+-melibiose symporter activity" EXACT []
synonym: "Na+/melibiose symporter activity" EXACT []
synonym: "Na+:melibiose symporter activity" EXACT []
synonym: "sodium-melibiose symporter activity" EXACT []
synonym: "sodium/melibiose symporter activity" EXACT []
synonym: "sodium:melibiose symporter activity" EXACT []
synonym: "thiomethylgalactoside permease II" RELATED []
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0015487 ! melibiose:monoatomic cation symporter activity

[Term]
id: GO:0043888
name: obsolete (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate." [PMID:15356000, PMID:16494480]
comment: This function is involved in archaeal lipid synthesis. The reason for obsoletion is that this term is equivalent to GO:0047295 geranylgeranylglycerol-phosphate geranylgeranyltransferase activity.
synonym: "2,3-dGGGPS" EXACT []
synonym: "DGGGP synthase activity" EXACT []
synonym: "DGGGPS" EXACT []
synonym: "UbiA" RELATED []
is_obsolete: true
replaced_by: GO:0047295

[Term]
id: GO:0043889
name: obsolete (S)-3-O-geranylgeranylglyceryl phosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction:(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate." [PMID:12801917, PMID:17253090, PMID:8408023]
comment: This function is involved in archaeal lipid synthesis. The reason for obsoletion is that this term is equivalent to GO:0047294 phosphoglycerol geranylgeranyltransferase activity.
synonym: "(S)-3-O-geranylgeranylglycerylphosphate synthase activity" EXACT []
synonym: "(S)-GGGP synthase activity" EXACT []
synonym: "GGGP synthase activity" EXACT []
synonym: "GGGPS" EXACT []
is_obsolete: true
replaced_by: GO:0047294

[Term]
id: GO:0043890
name: N-acetylgalactosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4]
synonym: "acetylgalactosamine 6-sulfatase activity" EXACT []
synonym: "chondroitin sulfatase" BROAD []
synonym: "chondroitinase" BROAD []
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4]
synonym: "galactose-6-sulfate sulfatase activity" EXACT []
synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT []
synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT []
synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT []
xref: EC:3.1.6.4
xref: MetaCyc:3.1.6.4-RXN
xref: Reactome:R-HSA-1630304 "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate"
xref: Reactome:R-HSA-2263490 "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate"
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0043891
name: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59]
synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT []
synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" RELATED [EC:1.2.1.59]
synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT []
synonym: "triosephosphate dehydrogenase (NAD(P)+)" RELATED [EC:1.2.1.59]
xref: EC:1.2.1.59
xref: MetaCyc:GAPDHSYNEC-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043892
name: methylglyoxal reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283]
synonym: "Gre2" RELATED []
synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT []
synonym: "lactaldehyde:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.283]
synonym: "methylglyoxal reductase (NADPH-dependent) activity" EXACT []
xref: EC:1.1.1.283
xref: MetaCyc:1.1.1.283-RXN
xref: RHEA:21748
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043893
name: acetate:monoatomic cation symporter activity
namespace: molecular_function
def: "Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl, PMID:14563880]
synonym: "acetate permease" BROAD []
synonym: "acetate-cation symporter activity" EXACT []
synonym: "acetate/cation symporter activity" EXACT []
synonym: "acetate:cation symporter activity" BROAD []
synonym: "ActP" RELATED []
synonym: "cation-acetate symporter activity" EXACT []
synonym: "cation/acetate symporter activity" EXACT []
synonym: "cation:acetate symporter activity" EXACT []
is_a: GO:0015123 ! acetate transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity

[Term]
id: GO:0043894
name: acetyl-CoA synthetase acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963]
synonym: "Pat" RELATED []
synonym: "Pat enzyme" EXACT []
synonym: "protein acetyltransferase activity" BROAD []
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0043895
name: cyclomaltodextrin glucanotransferase activity
namespace: molecular_function
def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19]
synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT []
synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED []
synonym: "alpha-cyclodextrin glucanotransferase" RELATED []
synonym: "alpha-cyclodextrin glycosyltransferase" RELATED []
synonym: "Bacillus macerans amylase" RELATED []
synonym: "beta-cyclodextrin glucanotransferase" RELATED []
synonym: "beta-cyclodextrin glycosyltransferase" RELATED []
synonym: "BMA" RELATED []
synonym: "CGTase" RELATED []
synonym: "cyclodextrin glucanotransferase" BROAD []
synonym: "cyclodextrin glycosyltransferase" RELATED []
synonym: "cyclomaltodextrin glucotransferase" RELATED []
synonym: "cyclomaltodextrin glycosyltransferase" RELATED []
synonym: "gamma-cyclodextrin glycosyltransferase" RELATED []
synonym: "konchizaimu" RELATED []
synonym: "neutral-cyclodextrin glycosyltransferase" RELATED []
xref: EC:2.4.1.19
xref: MetaCyc:2.4.1.19-RXN
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0043896
name: glucan 1,6-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70]
synonym: "exo-1,6-alpha-glucosidase activity" RELATED [EC:3.2.1.70]
synonym: "exo-1,6-beta-glucosidase" RELATED []
synonym: "glucan alpha-1,6-D-glucohydrolase activity" RELATED [EC:3.2.1.70]
synonym: "glucan-1,6-alpha-glucosidase activity" EXACT []
synonym: "glucodextranase activity" RELATED [EC:3.2.1.70]
synonym: "glucodextrinase" BROAD []
xref: EC:3.2.1.70
xref: MetaCyc:3.2.1.70-RXN
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0043897
name: glucan 1,4-alpha-maltohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133]
synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT []
synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT []
synonym: "maltogenic alpha-amylase activity" EXACT []
xref: EC:3.2.1.133
xref: MetaCyc:3.2.1.133-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0043898
name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866]
synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT []
synonym: "BphC" RELATED []
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0043899
name: phosphoserine:homoserine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121]
synonym: "thrH" RELATED []
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043900
name: obsolete regulation of multi-organism process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0043901
name: obsolete negative regulation of multi-organism process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0043902
name: obsolete positive regulation of multi-organism process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0043903
name: regulation of biological process involved in symbiotic interaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl]
comment: regulation of interspecies interactions between organisms
synonym: "regulation of interspecies interactions between organisms" BROAD []
synonym: "regulation of symbiosis, encompassing mutualism through parasitism" RELATED []
synonym: "regulation of symbiotic process" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0044403 ! biological process involved in symbiotic interaction

[Term]
id: GO:0043904
name: isochorismate pyruvate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: isochorismate = salicylate + pyruvate." [GOC:jl, PMID:16248620]
synonym: "IPL" EXACT []
synonym: "isochorismate-pyruvate lyase activity" EXACT []
xref: EC:4.2.99.21
xref: MetaCyc:RXN-1981
xref: RHEA:27874
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0043905
name: L-seryl-tRNA(Thr) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)." [GOC:jl, PMID:15240874]
synonym: "Ser-tRNA(Thr) hydrolase activity" EXACT []
synonym: "Ser-tRNAThr hydrolase activity" EXACT []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0043906
name: Ala-tRNA(Pro) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)." [GOC:jl, PMID:14663147]
synonym: "Ala-tRNAPro hydrolase activity" EXACT []
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0043907
name: Cys-tRNA(Pro) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)." [GOC:jl, PMID:15886196]
synonym: "Cys-tRNA(Pro) deacetylase activity" EXACT []
synonym: "Cys-tRNAPro hydrolase activity" EXACT []
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0043908
name: Ser(Gly)-tRNA(Ala) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147]
synonym: "Ser(Gly)-tRNAAla hydrolase activity" EXACT []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0043909
name: N-acetylcitrulline deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate." [GOC:jl, PMID:16750290, RHEA:61092]
synonym: "acetylcitrulline deacetylase activity" EXACT []
synonym: "N-acetyl-L-citrulline deacetylase activity" EXACT []
xref: RHEA:61092
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043910
name: ATP:coenzyme F420 adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate." [GOC:jl, MetaCyc:RXN-9385, PMID:7957247, PMID:8550473]
synonym: "ATP:coenzyme F420 adenyltransferase activity" EXACT []
synonym: "coenzyme F390-A synthetase activity" EXACT []
xref: MetaCyc:RXN-9385
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0043911
name: D-lysine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, PMID:17259313]
synonym: "D-lysine aminotransferase activity" EXACT []
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043912
name: obsolete D-lysine oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4+." [PMID:17259313]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0043913
name: obsolete chromosome segregation-directing complex
namespace: cellular_component
def: "OBSOLETE. A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918]
comment: This term was obsoleted because the three proteins mentioned in the definition are not part of the same complex.
synonym: "chromosome segregation directing complex" EXACT []
synonym: "longitudinal peptidoglycan synthesis-directing complex" EXACT []
synonym: "MreBCD complex" NARROW []
is_obsolete: true

[Term]
id: GO:0043914
name: NADPH:sulfur oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+." [GOC:jl, PMID:17449625]
synonym: "CoA-dependent NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H elemental sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H sulphur oxidoreductase activity" EXACT []
synonym: "NAD(P)H:sulfur oxidoreductase activity" EXACT []
synonym: "NADPH:sulphur oxidoreductase activity" EXACT []
synonym: "NSR" EXACT []
xref: EC:1.8.1.18
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043915
name: L-seryl-tRNA(Sec) kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, PMID:16201757, RHEA:25037]
synonym: "O-phosphoseryl-tRNA(Sec) kinase activity" EXACT []
xref: EC:2.7.1.164
xref: MetaCyc:RXN-10038
xref: RHEA:25037
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0043916
name: DNA-7-methylguanine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site." [GOC:jl, PMID:16468998]
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0043917
name: ribose 1,5-bisphosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [RHEA:32243]
synonym: "ribose-1,5-bisphosphate isomerase activity" EXACT []
xref: EC:5.3.1.29
xref: MetaCyc:RXN-8801
xref: RHEA:32243
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0043918
name: cadaverine aminopropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H+ + S-methyl-5'-thioadenosine." [PMID:17545282, RHEA:33387]
synonym: "cadaverine aminopropyl transferase activity" EXACT []
xref: RHEA:33387
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043919
name: agmatine aminopropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + S-adenosyl 3-(methylsulfanyl)propylamine = H+ + N1-(3-aminopropyl)agmatine + S-methyl-5'-thioadenosine." [PMID:15983049, RHEA:36487]
synonym: "agmatine aminopropyl transferase activity" EXACT []
xref: RHEA:36487
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043920
name: aminopropylagmatine ureohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, PMID:15983049, RHEA:35827]
xref: EC:3.5.3.24
xref: RHEA:35827
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0043921
name: modulation by host of viral transcription
namespace: biological_process
def: "Any process in which a host organism modulates the frequency, rate or extent of viral transcription." [GOC:jl]
synonym: "regulation by host of viral transcription" EXACT []
synonym: "regulation of viral transcription by host" EXACT []
is_a: GO:0043922 ! negative regulation by host of viral transcription
is_a: GO:0044793 ! negative regulation by host of viral process

[Term]
id: GO:0043922
name: negative regulation by host of viral transcription
namespace: biological_process
def: "Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:jl]
synonym: "negative regulation of viral transcription by host" EXACT []
is_a: GO:0051851 ! modulation by host of symbiont process
relationship: negatively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0043923
name: positive regulation by host of viral transcription
namespace: biological_process
def: "Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl]
synonym: "positive regulation of viral transcription by host" EXACT []
is_a: GO:0051851 ! modulation by host of symbiont process
relationship: positively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0043924
name: suramin binding
namespace: molecular_function
def: "Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [GOC:jl, Wikipedia:Suramin]
synonym: "Germanin binding" EXACT []
is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043177 ! organic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043927
name: obsolete exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true
replaced_by: GO:0000956

[Term]
id: GO:0043928
name: obsolete exonucleolytic catabolism of deadenylated mRNA
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0000288

[Term]
id: GO:0043929
name: primary ovarian follicle growth involved in double layer follicle stage
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis." [GOC:mtg_mpo]
synonym: "primary ovarian follicle growth during double layer follicle stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001545 ! primary ovarian follicle growth
relationship: part_of GO:0048161 ! double layer follicle stage

[Term]
id: GO:0043930
name: primary ovarian follicle growth involved in primary follicle stage
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis." [GOC:mtg_mpo]
synonym: "primary ovarian follicle growth during primary follicle stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001545 ! primary ovarian follicle growth
relationship: part_of GO:0048160 ! primary follicle stage

[Term]
id: GO:0043931
name: ossification involved in bone maturation
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo]
synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034]
synonym: "ossification involved in skeletal development" EXACT [GOC:dph]
is_a: GO:0001503 ! ossification
relationship: part_of GO:0070977 ! bone maturation

[Term]
id: GO:0043932
name: ossification involved in bone remodeling
namespace: biological_process
def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo]
synonym: "ossification involved in bone remodelling" EXACT []
is_a: GO:0001503 ! ossification
relationship: part_of GO:0046849 ! bone remodeling

[Term]
id: GO:0043933
name: protein-containing complex organization
namespace: biological_process
alt_id: GO:0034600
alt_id: GO:0034621
alt_id: GO:0071822
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]
synonym: "cellular macromolecular complex organization" RELATED []
synonym: "cellular macromolecular complex subunit organisation" RELATED []
synonym: "cellular macromolecular complex subunit organization" RELATED []
synonym: "macromolecular complex organization" RELATED []
synonym: "macromolecular complex subunit organisation" RELATED []
synonym: "macromolecular complex subunit organization" RELATED []
synonym: "protein complex subunit organisation" EXACT [GOC:mah]
synonym: "protein complex subunit organization" EXACT []
synonym: "protein-containing complex subunit organization" RELATED []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043934
name: sporulation
namespace: biological_process
def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators]
subset: goslim_metagenomics
subset: goslim_yeast
xref: Wikipedia:Spore
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0043935
name: sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0034293 ! sexual sporulation

[Term]
id: GO:0043936
name: asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators]
synonym: "asexual reproduction resulting in the formation of a cellular spore" EXACT [GOC:di]
synonym: "asexual sporulation resulting in the formation of a viable spore" BROAD [GOC:di]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0030436 ! asexual sporulation

[Term]
id: GO:0043937
name: regulation of sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0043934 ! sporulation

[Term]
id: GO:0043938
name: positive regulation of sporulation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0043934 ! sporulation

[Term]
id: GO:0043939
name: negative regulation of sporulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0043934 ! sporulation

[Term]
id: GO:0043940
name: regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]
is_a: GO:0034306 ! regulation of sexual sporulation
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
relationship: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043941
name: positive regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
relationship: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043942
name: negative regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]
is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
relationship: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043943
name: regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
relationship: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043944
name: negative regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]
is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:1903665 ! negative regulation of asexual reproduction
relationship: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043945
name: positive regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore
is_a: GO:1903666 ! positive regulation of asexual reproduction
relationship: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043946
name: obsolete positive regulation of catalytic activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of enzyme activity in other organism" NARROW []
synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation of catalytic activity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" RELATED []
is_obsolete: true
consider: GO:0140677

[Term]
id: GO:0043947
name: obsolete positive regulation by host of symbiont catalytic activity
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation by host of symbiont enzyme activity" NARROW []
synonym: "activation of symbiont enzyme activity" NARROW []
synonym: "positive regulation by host of symbiont enzyme activity" EXACT []
synonym: "up regulation by host of symbiont enzyme activity" EXACT []
synonym: "up-regulation by host of symbiont enzyme activity" EXACT []
synonym: "upregulation by host of symbiont enzyme activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043948
name: obsolete induction by symbiont of host catalytic activity
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation by symbiont of host enzyme activity" NARROW []
synonym: "activation of host enzyme activity" NARROW []
synonym: "positive regulation by symbiont of host catalytic activity" EXACT []
synonym: "positive regulation by symbiont of host enzyme activity" EXACT []
synonym: "up regulation by symbiont of host enzyme activity" EXACT []
synonym: "up-regulation by symbiont of host enzyme activity" EXACT []
synonym: "upregulation by symbiont of host enzyme activity" EXACT []
is_obsolete: true

[Term]
id: GO:0043949
name: regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling." [GOC:jl]
synonym: "regulation of cAMP-mediated signalling" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043950
name: positive regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling." [GOC:jl]
synonym: "positive regulation of cAMP-mediated signalling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043951
name: negative regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling." [GOC:jl]
synonym: "negative regulation of cAMP-mediated signalling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043952
name: protein transport by the Sec complex
namespace: biological_process
def: "The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'protein secretion by the type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported.
synonym: "protein secretion by the Sec complex" NARROW []
synonym: "protein translocation by the Sec complex" NARROW []
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0043953
name: protein transport by the Tat complex
namespace: biological_process
def: "The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported.
synonym: "protein secretion by the TAT complex" NARROW []
synonym: "protein translocation by the TAT complex" NARROW []
synonym: "protein translocation by the twin-arginine translocation complex" NARROW []
synonym: "twin-arginine translocation pathway" EXACT []
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0043954
name: cellular component maintenance
namespace: biological_process
alt_id: GO:0071956
def: "The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah]
synonym: "cellular component maintenance at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043955
name: 3-hydroxypropionyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
synonym: "3-hydroxy propionyl-CoA synthetase activity" EXACT []
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" NARROW []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:6.2.1.36
xref: RHEA:26534
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043956
name: 3-hydroxypropionyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
synonym: "3-hydroxy propionyl-CoA dehydratase activity" EXACT []
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:4.2.1.116
xref: MetaCyc:RXN-6383
xref: RHEA:26518
is_a: GO:0004300 ! enoyl-CoA hydratase activity

[Term]
id: GO:0043957
name: acryloyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399, RHEA:26454]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD []
synonym: "acrylyl-CoA reductase (NADPH) activity" EXACT []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:1.3.1.84
xref: KEGG_REACTION:R00919
xref: MetaCyc:RXN-9087
xref: RHEA:26454
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043958
name: acryloyl-CoA reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH." [GOC:jl, PMID:12603323]
comment: Note that this function is part of the process of L-alanine fermentation to propionate.
synonym: "acryloyl-CoA reductase activity" BROAD []
synonym: "acryloyl-coenzyme A reductase activity" BROAD []
synonym: "acrylyl-CoA reductase (NADH)" EXACT []
synonym: "propionyl-CoA dehydrogenase" BROAD []
xref: EC:1.3.1.95
xref: MetaCyc:RXN-8568
xref: RHEA:34471
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043959
name: L-erythro-3-methylmalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA." [RHEA:38259]
synonym: "HpcH/HpaI aldolase" RELATED []
xref: RHEA:38259
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0043960
name: L-erythro-3-methylmalyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O." [GOC:jl]
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043961
name: succinyl-CoA:(R)-citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, PMID:17259315]
synonym: "L-carnitine dehydratase/bile acid-inducible protein F" RELATED []
synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT []
synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT []
xref: EC:2.8.3.20
xref: MetaCyc:RXN-8966
xref: RHEA:38279
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043962
name: obsolete negative regulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0043963
name: obsolete perturbation of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont alters or subverts an adenylate cyclase-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is redundant with other terms: 'symbiont-mediated cAMP intoxication of host cell ; GO:0141042' and 'perturbation of host G protein-coupled receptor signal transduction pathway ; GO:0075118'.
is_obsolete: true
consider: GO:0075118
consider: GO:0141042

[Term]
id: GO:0043964
name: obsolete induction by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0043965
name: obsolete symbiont-mediated suppression of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a virus interferes with, inhibits or disrupts an adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is redundant with other terms: 'symbiont-mediated cAMP intoxication of host cell ; GO:0141042' and 'perturbation of host G protein-coupled receptor signal transduction pathway ; GO:0075118'.
synonym: "disruption of host adenylate cyclase-mediated signal transduction" EXACT []
synonym: "negative regulation by symbiont of host adenylate cyclase-mediated signal transduction" EXACT []
synonym: "suppression by symbiont of host adenylate cyclase-mediated signal transduction" EXACT []
is_obsolete: true
consider: GO:0075118
consider: GO:0141042

[Term]
id: GO:0043966
name: obsolete histone H3 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0043967
name: obsolete histone H4 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0043968
name: obsolete histone H2A acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of an acetyl group." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0043969
name: obsolete histone H2B acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2B by the addition of an acetyl group." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0043970
name: obsolete histone H3-K9 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K9" EXACT []
synonym: "histone H3K9 acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0043971
name: obsolete histone H3-K18 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K18" EXACT []
synonym: "histone H3K18 acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0043972
name: obsolete histone H3-K23 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K23" EXACT []
synonym: "histone H3K23 acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0043973
name: obsolete histone H3-K4 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K4" EXACT []
synonym: "histone H3K4 acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0043974
name: obsolete histone H3-K27 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K27" EXACT []
synonym: "histone H3K27 acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0043975
name: obsolete histone H3-K36 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K36" EXACT []
synonym: "histone H3K36 acetylation" EXACT []
is_obsolete: true
consider: GO:0044018

[Term]
id: GO:0043976
name: obsolete histone H3-K79 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K79" EXACT []
synonym: "histone H3K79 acetylation" EXACT []
is_obsolete: true
consider: GO:0031151

[Term]
id: GO:0043977
name: obsolete histone H2A-K5 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A acetylation at K5" EXACT []
is_obsolete: true

[Term]
id: GO:0043978
name: obsolete histone H2A-K9 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A acetylation at K9" EXACT []
is_obsolete: true
consider: GO:0044012

[Term]
id: GO:0043979
name: obsolete histone H2B-K5 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2B acetylation at K5" EXACT []
is_obsolete: true

[Term]
id: GO:0043980
name: obsolete histone H2B-K12 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2B acetylation at K12" EXACT []
is_obsolete: true

[Term]
id: GO:0043981
name: obsolete histone H4-K5 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 acetylation at K5" EXACT []
is_obsolete: true

[Term]
id: GO:0043982
name: obsolete histone H4-K8 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 acetylation at K8" EXACT []
is_obsolete: true

[Term]
id: GO:0043983
name: obsolete histone H4-K12 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 acetylation at K12" EXACT []
is_obsolete: true

[Term]
id: GO:0043984
name: obsolete histone H4-K16 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 acetylation at K16" EXACT []
is_obsolete: true

[Term]
id: GO:0043985
name: obsolete histone H4-R3 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 methylation at R3" EXACT []
synonym: "histone H4 R3 methylation" EXACT []
synonym: "histone H4R3me" EXACT []
is_obsolete: true

[Term]
id: GO:0043987
name: obsolete histone H3-S10 phosphorylation
namespace: biological_process
alt_id: GO:0043986
def: "OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 phosphorylation at S10" EXACT []
synonym: "histone H3S10 phosphorylation" EXACT []
is_obsolete: true
consider: GO:0035175

[Term]
id: GO:0043988
name: obsolete histone H3-S28 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 phosphorylation at S28" EXACT []
synonym: "histone H3S28 phosphorylation" EXACT []
is_obsolete: true
consider: GO:0044022

[Term]
id: GO:0043989
name: obsolete histone H4-S1 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H4 phosphorylation at S1" EXACT []
synonym: "histone H4S1 phosphorylation" EXACT []
is_obsolete: true
consider: GO:0044023

[Term]
id: GO:0043990
name: obsolete histone H2A-S1 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A phosphorylation at S1" EXACT []
synonym: "histone H2AS1 phosphorylation" EXACT []
is_obsolete: true
consider: GO:0044024

[Term]
id: GO:0043991
name: obsolete histone H2B-S14 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2B phosphorylation at S14" EXACT []
synonym: "histone H2BS14 phosphorylation" EXACT []
is_obsolete: true
consider: GO:0044025

[Term]
id: GO:0043992
name: histone H3K9 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [PMID:18552846, PMID:19056256]
synonym: "histone acetylase activity (H3-K9 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K9 specific)" EXACT []
synonym: "histone H3-K9 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K9 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0043993
name: histone H3K18 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [PMID:18552846]
synonym: "histone acetylase activity (H3-K18 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K18 specific)" EXACT []
synonym: "histone H3-K18 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K18 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0043994
name: histone H3K23 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [PMID:18552846, PMID:19056256]
synonym: "histone acetylase activity (H3-K23 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K23 specific)" EXACT []
synonym: "histone H3-K23 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K23 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0043995
name: histone H4K5 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [PMID:18552846, PMID:19056256]
synonym: "histone acetylase activity (H4-K5 specific)" EXACT []
synonym: "histone acetyltransferase activity (H4-K5 specific)" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H4-K5 specific)" EXACT []
is_a: GO:0010485 ! histone H4 acetyltransferase activity

[Term]
id: GO:0043996
name: histone H4K8 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [PMID:18552846, PMID:19056256]
synonym: "histone acetylase activity (H4-K8 specific)" EXACT []
synonym: "histone acetyltransferase activity (H4-K8 specific)" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H4-K8 specific)" EXACT []
is_a: GO:0010485 ! histone H4 acetyltransferase activity

[Term]
id: GO:0043997
name: histone H4K12 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [PMID:18552846, PMID:19056256]
synonym: "histone acetylase activity (H4-K12 specific)" EXACT []
synonym: "histone acetyltransferase activity (H4-K12 specific)" EXACT []
synonym: "histone H4-K12 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H4-K12 specific)" EXACT []
is_a: GO:0010485 ! histone H4 acetyltransferase activity

[Term]
id: GO:0043998
name: histone H2A acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [PMID:19056256]
synonym: "H2A histone acetylase activity" EXACT []
synonym: "H2A histone acetyltransferase activity" EXACT []
synonym: "H2A histone lysine N-acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0043999
name: histone H2AK5 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [PMID:18552846, PMID:19056256]
comment: Note that in yeast, this is corresponds to H2AK4.
synonym: "histone acetylase activity (H2A-K5 specific)" EXACT []
synonym: "histone acetyltransferase activity (H2A-K5 specific)" EXACT []
synonym: "histone H2A-K5 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H2A-K5 specific)" EXACT []
is_a: GO:0043998 ! histone H2A acetyltransferase activity

[Term]
id: GO:0044000
name: obsolete movement in host
namespace: biological_process
alt_id: GO:0052126
def: "OBSOLETE. The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "movement in host environment" RELATED []
synonym: "movement of symbiont in host" EXACT []
synonym: "movement of symbiont within host" EXACT []
synonym: "movement within host" EXACT []
synonym: "symbiont movement in host" EXACT []
synonym: "symbiont movement within host" RELATED []
is_obsolete: true
consider: GO:0035891
consider: GO:0044001
consider: GO:0044409

[Term]
id: GO:0044001
name: migration in host
namespace: biological_process
def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "migration within host" EXACT []
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044002
name: acquisition of nutrients from host
namespace: biological_process
def: "The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044003
name: symbiont-mediated perturbation of host process
namespace: biological_process
alt_id: GO:0044004
alt_id: GO:0044055
alt_id: GO:0052065
alt_id: GO:0052251
alt_id: GO:0052265
alt_id: GO:0052389
alt_id: GO:0052509
alt_id: GO:0052510
def: "A process in which a symbiont alters or subverts a biological process in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: goslim_virus
synonym: "disruption by symbiont of host cell" RELATED []
synonym: "modification by symbiont of host biological process" RELATED []
synonym: "modification by symbiont of host morphology or physiology" RELATED []
synonym: "modulation by symbiont of host system process" NARROW []
synonym: "pathogenesis" RELATED []
synonym: "regulation by symbiont of host system process" NARROW []
is_a: GO:0035821 ! modulation of process of another organism
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044007
name: obsolete dissemination or transmission of symbiont from host
namespace: biological_process
def: "OBSOLETE. The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont.
synonym: "dissemination or transmission of organism from host" EXACT []
is_obsolete: true

[Term]
id: GO:0044008
name: obsolete dissemination or transmission of symbiont from host by vector
namespace: biological_process
def: "OBSOLETE. The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont.
synonym: "dissemination or transmission of organism from host by vector" EXACT []
is_obsolete: true

[Term]
id: GO:0044009
name: obsolete viral transmission by vector
namespace: biological_process
def: "OBSOLETE. The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc]
comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a virus.
is_obsolete: true

[Term]
id: GO:0044010
name: single-species biofilm formation
namespace: biological_process
alt_id: GO:0052000
def: "A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb]
synonym: "auto-aggregation" BROAD []
synonym: "bfp-dependent aggregation" NARROW []
synonym: "bundle-forming fimbriae-dependent aggregation" NARROW []
synonym: "bundle-forming pili-dependent aggregation" NARROW []
synonym: "tfp-dependent aggregation" NARROW []
synonym: "type IV pili-dependent aggregation" NARROW []
is_a: GO:0042710 ! biofilm formation
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms

[Term]
id: GO:0044011
name: single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc]
is_a: GO:0090609 ! single-species submerged biofilm formation

[Term]
id: GO:0044012
name: histone H2AK9 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [PMID:18552846]
comment: Note that in yeast, this is corresponds to H2AK7.
synonym: "histone acetylase activity (H2A-K9 specific)" EXACT []
synonym: "histone acetyltransferase activity (H2A-K9 specific)" EXACT []
synonym: "histone H2A-K9 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H2A-K9 specific)" EXACT []
is_a: GO:0043998 ! histone H2A acetyltransferase activity

[Term]
id: GO:0044013
name: histone H2B acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [PMID:19056256]
synonym: "H2B histone acetylase activity" EXACT []
synonym: "H2B histone acetyltransferase activity" EXACT []
synonym: "H2B histone lysine N-acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0044014
name: histone H2BK5 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [PMID:18552846]
synonym: "histone acetylase activity (H2B-K5 specific)" EXACT []
synonym: "histone acetyltransferase activity (H2B-K5 specific)" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H2B-K5 specific)" EXACT []
is_a: GO:0044013 ! histone H2B acetyltransferase activity

[Term]
id: GO:0044015
name: histone H2BK12 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [PMID:18552846]
synonym: "histone acetylase activity (H2B-K12 specific)" EXACT []
synonym: "histone acetyltransferase activity (H2B-K12 specific)" EXACT []
synonym: "histone H2B-K12 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H2B-K12 specific)" EXACT []
is_a: GO:0044013 ! histone H2B acetyltransferase activity

[Term]
id: GO:0044016
name: histone H3K4 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [PMID:18552846]
synonym: "histone acetylase activity (H3-K4 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K4 specific)" EXACT []
synonym: "histone H3-K4 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K4 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0044017
name: histone H3K27 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [PMID:18552846]
synonym: "histone acetylase activity (H3-K27 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K27 specific)" EXACT []
synonym: "histone H3-K27 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K27 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0044018
name: histone H3K36 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [PMID:18552846]
synonym: "histone acetylase activity (H3-K36 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K36 specific)" EXACT []
synonym: "histone H3-K36 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K36 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0044019
name: obsolete histone H3K72 acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this activity exists.
synonym: "histone acetylase activity (H3-K72 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K72 specific)" EXACT []
synonym: "histone H3-K72 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K72 specific)" EXACT []
is_obsolete: true

[Term]
id: GO:0044020
name: histone H4R3 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me." [GOC:mah, PMID:17898714]
synonym: "histone H4KR3 methylation" EXACT []
synonym: "histone H4R3 arginine methylase activity" EXACT []
synonym: "histone methylase activity (H4-R3 specific)" EXACT [GOC:mah]
synonym: "histone methyltransferase activity (H4-R3 specific)" EXACT []
synonym: "histone-arginine N-methyltransferase activity (H4-R3 specific)" EXACT []
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0140939 ! histone H4 methyltransferase activity

[Term]
id: GO:0044022
name: histone H3S28 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3." [GOC:jl]
synonym: "histone kinase activity (H3-S28 specific)" EXACT []
synonym: "histone serine kinase activity (H3-S28 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S28 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0044023
name: histone H4S1 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H4-serine (position 1) + ATP = histone H4-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H4." [GOC:jl]
synonym: "histone kinase activity (H4-S1 specific)" EXACT []
synonym: "histone serine kinase activity (H4-S1 specific)" EXACT []
synonym: "histone-serine kinase activity (H4-S1 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140997 ! histone H4 kinase activity

[Term]
id: GO:0044024
name: histone H2AS1 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2A-serine (position 1) + ATP = histone H2A-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H2A." [GOC:jl]
synonym: "histone kinase activity (H2A-S1 specific)" EXACT []
synonym: "histone serine kinase activity (H2A-S1 specific)" EXACT []
synonym: "histone-serine kinase activity (H2A-S1 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140995 ! histone H2A kinase activity

[Term]
id: GO:0044025
name: histone H2BS14 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2B-serine (position 14) + ATP = histone H2B-phosphoserine (position 14) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 14 of histone H2B." [GOC:jl]
synonym: "histone kinase activity (H2B-S14 specific)" EXACT []
synonym: "histone serine kinase activity (H2B-S14 specific)" EXACT []
synonym: "histone-serine kinase activity (H2B-S14 specific)" EXACT []
xref: https://github.com/geneontology/go-ontology/issues/28520
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140998 ! histone H2B kinase activity

[Term]
id: GO:0044026
name: obsolete DNA hypermethylation
namespace: biological_process
def: "OBSOLETE. An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]
comment: The reason for obsoletion is this is a readout.
is_obsolete: true
consider: GO:0040029

[Term]
id: GO:0044027
name: negative regulation of gene expression via chromosomal CpG island methylation
namespace: biological_process
def: "An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes." [PMID:11898023, Wikipedia:Cpg_island]
synonym: "DNA hypermethylation of CG island" RELATED []
synonym: "DNA hypermethylation of CpG island" EXACT []
synonym: "epigenetic regulation of gene expression via CpG island hypermethylation" EXACT []
synonym: "hypermethylation of CpG island" EXACT []
synonym: "maintenance of DNA methylation" BROAD []
synonym: "negative regulation of gene expression via chromosomal CG dinucleotide methylation" RELATED []
synonym: "negative regulation of gene expression via chromosomal CpG dinucleotide methylation" EXACT []
synonym: "negative regulation of gene expression via chromosomal DNA cytosine methylation" EXACT []
synonym: "negative regulation of gene expression via CpG island hypermethylation" EXACT []
synonym: "negative regulation of gene expression via CpG island methylation" RELATED []
is_a: GO:0045814 ! negative regulation of gene expression, epigenetic

[Term]
id: GO:0044028
name: obsolete DNA hypomethylation
namespace: biological_process
def: "OBSOLETE. An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/hypomethylation]
comment: The reason for obsoletion is that this is a readout.
is_obsolete: true
consider: GO:0040029

[Term]
id: GO:0044029
name: positive regulation of gene expression via chromosomal CpG island demethylation
namespace: biological_process
def: "An epigenetic gene regulation mechanism that positively regulates gene expression by demethylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [PMID:36150101, Wikipedia:Cpg_island]
synonym: "DNA demethylation" BROAD []
synonym: "DNA hypomethylation of CpG island" EXACT []
synonym: "hypomethylation of CpG island" EXACT []
synonym: "positive regulation of gene expression via chromosomal CpG dinucleotide demethylation" EXACT []
is_a: GO:0045815 ! transcription initiation-coupled chromatin remodeling

[Term]
id: GO:0044030
name: obsolete regulation of DNA methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl]
comment: This term was obsoleted because it represents regulation of a molecular function.
is_obsolete: true
consider: GO:0030234
consider: GO:0040029

[Term]
id: GO:0044031
name: obsolete modification by symbiont of host protein by phosphorylation
namespace: biological_process
def: "OBSOLETE. The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0044032
name: obsolete modulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation by symbiont of auxin levels in host" BROAD []
synonym: "modulation by symbiont of IAA levels in host" EXACT []
is_obsolete: true

[Term]
id: GO:0044033
name: obsolete multi-organism metabolic process
namespace: biological_process
def: "OBSOLETE. A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi-organism metabolism" EXACT []
synonym: "multi-organismal metabolic process" EXACT []
synonym: "multi-organismal metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0044034
name: obsolete multi-organism biosynthetic process
namespace: biological_process
def: "OBSOLETE. A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi-organism biosynthesis" EXACT []
synonym: "multi-organismal biosynthesis" EXACT []
synonym: "multi-organismal biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0044035
name: obsolete multi-organism catabolic process
namespace: biological_process
def: "OBSOLETE. A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi-organism catabolism" EXACT []
synonym: "multi-organismal catabolic process" EXACT []
synonym: "multi-organismal catabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0044036
name: cell wall macromolecule metabolic process
namespace: biological_process
alt_id: GO:0010382
def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah]
synonym: "cellular cell wall macromolecule metabolic process" EXACT []
synonym: "cellular cell wall macromolecule metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
relationship: part_of GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0044037
name: obsolete multi-organism cell wall macromolecule metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah, GOC:tair_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi-organism cell wall macromolecule metabolism" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0044038
name: cell wall macromolecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall." [GOC:go_curators]
synonym: "cell wall macromolecule anabolism" EXACT [GOC:mah]
synonym: "cell wall macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "cell wall macromolecule biosynthetic process at cellular level" EXACT [GOC:mah]
synonym: "cell wall macromolecule synthesis" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule biosynthetic process" EXACT [GOC:mah]
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0044040
name: obsolete multi-organism carbohydrate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "main pathways of carbohydrate metabolic process" NARROW []
synonym: "main pathways of carbohydrate metabolism" NARROW []
synonym: "multi-organism carbohydrate metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0044041
name: obsolete multi-organism carbohydrate catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi-organism carbohydrate breakdown" EXACT []
synonym: "multi-organism carbohydrate catabolism" EXACT []
synonym: "multi-organism carbohydrate degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0044042
name: glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl]
synonym: "glucan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0044043
name: obsolete multi-organism glucan metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism." [ISBN:0198547684]
comment: This term was obsoleted because there is no evidence it exists.
synonym: "multi-organism glucan metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0044044
name: obsolete interaction with host via substance in symbiont surface
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: The reason for obsoletion is that these terms conflate a process and the mechanism of secretion of the compound mediating the process.
is_obsolete: true

[Term]
id: GO:0044045
name: obsolete interaction with host via substance in symbiont cell outer membrane
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: The reason for obsoletion is that these terms conflate a process and the mechanism of secretion of the compound mediating the process.
is_obsolete: true

[Term]
id: GO:0044046
name: obsolete interaction with host via substance released outside of symbiont
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk]
comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process.
synonym: "interaction with host via substance released outside of symbiont cells" EXACT []
is_obsolete: true

[Term]
id: GO:0044047
name: obsolete interaction with host via protein secreted by type I secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0044048
name: obsolete interaction with host via protein secreted by type V secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0044049
name: obsolete interaction with host via protein secreted by type VI secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0044050
name: obsolete interaction with host via substance released by sporangium lysis
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process.
synonym: "interaction with host via substance released by lysis of symbiont sporangium" RELATED []
synonym: "interaction with host via substance released by sporangia lysis" EXACT []
is_obsolete: true

[Term]
id: GO:0044051
name: obsolete interaction with host via substance released by symbiont cytolysis
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process.
synonym: "interaction with host via substance released by cytolysis of symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0044052
name: obsolete interaction with host via substance released by membrane budding
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle." [MITRE:tk]
comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process.
synonym: "interaction with host via substance released by symbiont membrane budding" EXACT []
is_obsolete: true

[Term]
id: GO:0044053
name: translocation of peptides or proteins into host cell cytoplasm
namespace: biological_process
def: "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm." [MITRE:tk]
synonym: "translocation of symbiont peptides or proteins into host cell cytoplasm" EXACT []
synonym: "transport of peptides or proteins into host cell cytoplasm" EXACT []
is_a: GO:0042000 ! translocation of peptides or proteins into host

[Term]
id: GO:0044056
name: obsolete modulation by symbiont of host digestive system process
namespace: biological_process
def: "OBSOLETE. The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [MITRE:tk]
comment: This term was obsoleted because it is not sufficiently precise.
synonym: "regulation by symbiont of host digestive system process" EXACT []
is_obsolete: true

[Term]
id: GO:0044057
name: regulation of system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0003008 ! system process

[Term]
id: GO:0044058
name: regulation of digestive system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0022600 ! digestive system process

[Term]
id: GO:0044059
name: obsolete modulation by symbiont of host endocrine process
namespace: biological_process
def: "OBSOLETE. The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism." [MITRE:tk]
comment: This term was obsoleted because it is not sufficiently precise.
synonym: "regulation by symbiont of host endocrine process" EXACT []
is_obsolete: true

[Term]
id: GO:0044060
name: regulation of endocrine process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl]
synonym: "regulation of endocrine system process" EXACT []
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0050886 ! endocrine process

[Term]
id: GO:0044061
name: obsolete modulation by symbiont of host excretion
namespace: biological_process
def: "OBSOLETE. The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity." [MITRE:tk]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation by symbiont of host excretion" EXACT []
is_obsolete: true

[Term]
id: GO:0044062
name: regulation of excretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0007588 ! excretion

[Term]
id: GO:0044063
name: obsolete modulation by symbiont of host nervous system process
namespace: biological_process
def: "OBSOLETE. The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk]
comment: This term was obsoleted because it is not sufficiently precise.
synonym: "modulation by symbiont of host neurological system process" EXACT []
synonym: "regulation by symbiont of host neurological system process" EXACT []
is_obsolete: true

[Term]
id: GO:0044064
name: obsolete modulation by symbiont of host respiratory system process
namespace: biological_process
def: "OBSOLETE. The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [MITRE:tk]
comment: This term was obsoleted because it is not sufficiently precise.
synonym: "regulation by symbiont of host respiratory system process" EXACT []
is_obsolete: true

[Term]
id: GO:0044065
name: regulation of respiratory system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0003016 ! respiratory system process

[Term]
id: GO:0044066
name: symbiont-mediated disruption of host cell nucleus
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host cell nucleus." [MITRE:tk]
synonym: "disruption by symbiont of host cell nucleus" EXACT []
synonym: "modification by symbiont of host cell nucleus" RELATED []
synonym: "modification by symbiont of host nucleus" EXACT []
synonym: "modification of host cell nucleus by symbiont" EXACT []
synonym: "modification of host nucleus by symbiont" EXACT []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0044067
name: symbiont-mediated perturbation of host cell-cell junction
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or temporarily subverts the host intercellular junction. Intercellular junction include tight junctions and adherens junctions." [PMID:16102958]
synonym: "disruption of host cell-cell junction" BROAD []
synonym: "modification by symbiont of host cell-cell junction" EXACT []
synonym: "modification by symbiont of host intercellular junctions" EXACT []
synonym: "modification of host cell-cell junction" RELATED []
synonym: "modification of host intercellular junctions by symbiont" EXACT []
synonym: "symbiont-mediated disruption of host cell-cell junction" RELATED []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0044068
name: symbiont-mediated perturbation of host cellular process
namespace: biological_process
def: "A process in which a symbiont alters or subverts a cellular biological process in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
synonym: "modulation by symbiont of host cellular process" EXACT []
synonym: "modulation of host cellular process by symbiont" EXACT []
synonym: "regulation by symbiont of host cellular process" EXACT []
synonym: "regulation of host cellular process by symbiont" EXACT []
is_a: GO:0044003 ! symbiont-mediated perturbation of host process

[Term]
id: GO:0044069
name: obsolete modulation by symbiont of host anion transport
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism." [MITRE:tk]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modification of host anion transport by symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0044070
name: regulation of monoatomic anion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "regulation of anion transport" BROAD []
is_a: GO:0043269 ! regulation of monoatomic ion transport
relationship: regulates GO:0006820 ! monoatomic anion transport

[Term]
id: GO:0044071
name: symbiont-mediated perturbation of host cell cycle progression
namespace: biological_process
def: "A process in which a symbiont interferes with the normal progression through the host cell cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
synonym: "modification by symbiont of host cell cycle" EXACT []
synonym: "modulation by symbiont of host cell cycle" EXACT []
synonym: "modulation of host cell cycle by symbiont" EXACT []
synonym: "perturbation of host cell cycle progression" EXACT []
synonym: "regulation by symbiont of host cell cycle" EXACT []
xref: VZ:1636
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0044072
name: obsolete symbiont-mediated suppression of host cell cycle progression
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont interferes with, inhibits or stops progression through the host cell cycle." [PMID:10946289, PMID:19308257]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "cell cycle arrest in host" RELATED []
synonym: "negative regulation by symbiont of host cell cycle" RELATED []
synonym: "suppression of host cell cycle progression" EXACT []
is_obsolete: true
consider: GO:0044071

[Term]
id: GO:0044073
name: obsolete modulation by symbiont of host translation
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]
comment: This term was obsoleted because it represents the same process as symbiont-mediated perturbation of host translation ; GO0019057.
synonym: "modification by symbiont of host translation" EXACT []
synonym: "modulation of host translation by symbiont" EXACT []
synonym: "regulation by symbiont of host translation" EXACT []
is_obsolete: true
replaced_by: GO:0019057

[Term]
id: GO:0044074
name: obsolete negative regulation by symbiont of host translation
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host translation ; GO:0039604.
synonym: "negative regulation of host translation by symbiont" EXACT []
is_obsolete: true
replaced_by: GO:0039604

[Term]
id: GO:0044075
name: symbiont-mediated perturbation of host vacuole organization
namespace: biological_process
def: "A process in which a symbiont alters or subverts vacuole organization in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:25139904]
synonym: "modulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah]
synonym: "modulation by symbiont of host vacuole organisation" EXACT [GOC:mah]
synonym: "modulation by symbiont of host vacuole organization" EXACT []
synonym: "modulation of host vacuole organization by symbiont" EXACT [GOC:mah]
synonym: "regulation by symbiont of host vacuole organization" EXACT [GOC:mah]
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0044076
name: obsolete positive regulation by symbiont of host vacuole organization
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk]
comment: This term was obsoleted because this process is not known to exist.
synonym: "positive regulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation by symbiont of host vacuole organisation" EXACT [GOC:mah]
synonym: "positive regulation of host vacuole organization by symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0044077
name: symbiont-mediated perturbation of host receptor-mediated endocytosis
namespace: biological_process
def: "A process in which a symbiont initiates, promotes, or enhances host receptor-mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
synonym: "modulation by symbiont of host receptor-mediated endocytosis" EXACT []
synonym: "modulation of host receptor-mediated endocytosis by symbiont" EXACT []
synonym: "regulation by symbiont of host receptor-mediated endocytosis" EXACT []
is_a: GO:1990215 ! symbiont-mediated perturbation of host vesicle-mediated transport

[Term]
id: GO:0044078
name: obsolete positive regulation by symbiont of host receptor-mediated endocytosis
namespace: biological_process
def: "OBSOLETE. Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of host receptor-mediated endocytosis by symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0044079
name: symbiont-mediated perturbation of host neurotransmitter secretion
namespace: biological_process
def: "A process in which a symbiont alters or subverts the regulated release of a neurotransmitter from a cell in its host organism." [MITRE:tk]
synonym: "modification by symbiont of host neurotransmitter secretion" EXACT []
synonym: "modulation by symbiont of host neurotransmitter secretion" EXACT []
synonym: "modulation of host neurotransmitter secretion by symbiont" EXACT []
synonym: "regulation by symbiont of host neurotransmitter secretion" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0044080
name: obsolete symbiont-mediated perturbation of host cGMP-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont alters or subverts a cGMP-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
comment: This term was obsoleted because it was not clearly defined: the pathway perturbed is not clearly defined.
synonym: "modulation by symbiont of host cGMP-mediated signal transduction" EXACT []
synonym: "modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT []
synonym: "modulation by symbiont of host cGMP-mediated signaling" EXACT []
synonym: "modulation by symbiont of host cGMP-mediated signalling" EXACT []
synonym: "modulation of host cGMP-mediated signal transduction by symbiont" EXACT []
synonym: "perturbation of host cGMP-mediated signal transduction" EXACT []
synonym: "regulation by symbiont of host cGMP-mediated signal transduction" EXACT []
is_obsolete: true
consider: GO:0141074

[Term]
id: GO:0044081
name: obsolete symbiont-mediated suppression of host nitric oxide-mediated signaling
namespace: biological_process
def: "OBSOLETE. A process in which a virus interferes with, inhibits or disrupts a nitric oxide mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk, PMID:23167250, PMID:29089430]
comment: This term was obsoleted because there is no evidence that this process exists; ie that a symbiont directly interferes with a host's notric oxide-mediated signaling pathway.
synonym: "disruption of host nitric oxide-mediated signaling" EXACT []
synonym: "modulation by symbiont of host nitric oxide mediated signal transduction" EXACT []
synonym: "modulation of host nitric oxide-mediated signal transduction by symbiont" EXACT []
synonym: "modulation of host nitric oxide-mediated signaling by symbiont" EXACT []
synonym: "modulation of host nitric oxide-mediated signalling by symbiont" EXACT []
synonym: "regulation by symbiont of host nitric oxide-mediated signal transduction" BROAD []
synonym: "suppression of host nitric oxide-mediated signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0044082
name: symbiont-mediated perturbation of host small GTPase-mediated signal transduction
namespace: biological_process
def: "A process in which a symbiont alters or subverts a small GTPase-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
synonym: "modulation by symbiont of host small GTPase mediated signal transduction" EXACT []
synonym: "modulation of host small GTPase mediated signal transduction by symbiont" EXACT []
synonym: "perturbation of host small GTPase mediated signal transduction" EXACT []
synonym: "regulation by symbiont of host small GTPase mediated signal transduction" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0044083
name: symbiont-mediated perturbation of host Rho small GTPase signal transduction
namespace: biological_process
def: "A process in which a symbiont alters a Rho protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15694861, PMID:17689917, PMID:30201700]
synonym: "modulation by symbiont of host Rho protein mediated signal transduction" EXACT []
synonym: "modulation by symbiont of host Rho protein signal transduction" EXACT []
synonym: "modulation by symbiont of host Rho protein-mediated signal transduction" EXACT []
synonym: "modulation of host Rho protein signal transduction by symbiont" EXACT []
synonym: "modulation of host Rho protein signaling by symbiont" EXACT []
synonym: "modulation of host Rho protein signalling by symbiont" EXACT []
synonym: "perturbation of host Rho protein signal transduction" EXACT []
synonym: "regulation by symbiont of host Rho protein signal transduction" EXACT []
synonym: "symbiont-mediated perturbation of host Rho protein signal transduction" EXACT []
is_a: GO:0044082 ! symbiont-mediated perturbation of host small GTPase-mediated signal transduction

[Term]
id: GO:0044084
name: host cell membrane pore complex
namespace: cellular_component
def: "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins." [MITRE:tk]
synonym: "pore complex in host cell membrane" EXACT []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane

[Term]
id: GO:0044085
name: cellular component biogenesis
namespace: biological_process
alt_id: GO:0071843
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular component biogenesis at cellular level" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0044087
name: regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044088
name: regulation of vacuole organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044089
name: positive regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044090
name: positive regulation of vacuole organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044088 ! regulation of vacuole organization
relationship: positively_regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044091
name: membrane biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044092
name: negative regulation of molecular function
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
subset: gocheck_do_not_annotate
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0044093
name: positive regulation of molecular function
namespace: biological_process
def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0044094
name: host cell nuclear part
namespace: cellular_component
def: "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0042025 ! host cell nucleus

[Term]
id: GO:0044095
name: host cell nucleoplasm
namespace: cellular_component
def: "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0044096
name: type IV pilus
namespace: cellular_component
def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers." [GOC:pamgo_curators, PMID:28496159]
synonym: "TFP" EXACT []
synonym: "type 4 pilus" EXACT []
synonym: "type IV fimbriae" EXACT []
is_a: GO:0009289 ! pilus

[Term]
id: GO:0044097
name: secretion by the type IV secretion system
namespace: biological_process
def: "The controlled release of proteins or DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators]
synonym: "secretion via the type IV secretion system" EXACT []
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0044098
name: DNA secretion by the type IV secretion system
namespace: biological_process
def: "The controlled release of DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators]
synonym: "DNA secretion via the type IV secretion system" EXACT []
is_a: GO:0044097 ! secretion by the type IV secretion system

[Term]
id: GO:0044099
name: polar tube
namespace: cellular_component
def: "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." [GOC:mf, PMID:12076771, PMID:9723921]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0044100
name: sporoplasm
namespace: cellular_component
def: "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms." [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921]
is_a: GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0044101
name: (3R)-citramalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-citramalyl-CoA = pyruvate + acetyl-CoA." [GOC:jl]
synonym: "Ccl" RELATED []
synonym: "R-citramalyl-CoA lyase activity" EXACT []
xref: EC:4.1.3.46
xref: MetaCyc:RXN-13231
xref: RHEA:38275
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0044102
name: purine deoxyribosyltransferase activity
namespace: molecular_function
def: "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor." [GOC:jl, PMID:11836245]
synonym: "PTD" RELATED []
synonym: "purine 2'-deoxyribosyltransferase activity" EXACT []
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0044103
name: L-arabinose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." [GOC:jl, PMID:16326697]
xref: EC:1.1.1.376
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044104
name: 2,5-dioxovalerate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+." [PMID:16835232, PMID:17202142]
synonym: "2,5-dioxopentanoate dehydrogenase (NAD+) activity" EXACT []
synonym: "2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity" EXACT []
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044105
name: L-xylulose reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+." [PMID:14736891, RHEA:68100]
xref: MetaCyc:RXN-11825
xref: RHEA:68100
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044107
name: obsolete cellular alcohol metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping classes.
is_obsolete: true
replaced_by: GO:0006066

[Term]
id: GO:0044108
name: obsolete cellular alcohol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping classes.
is_obsolete: true
replaced_by: GO:0046165

[Term]
id: GO:0044109
name: obsolete cellular alcohol catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping classes.
is_obsolete: true
replaced_by: GO:0046164

[Term]
id: GO:0044110
name: obsolete growth involved in symbiotic interaction
namespace: biological_process
alt_id: GO:0044153
def: "OBSOLETE. The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]
comment: This term has been obsoleted because it represents an assay for viability, not a real biological process.
synonym: "growth during symbiotic interaction" RELATED [GOC:dph]
synonym: "growth on or near surface of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "growth on or near surface of other organism involved in symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0044111
name: formation of structure involved in a symbiotic process
namespace: biological_process
alt_id: GO:0044115
alt_id: GO:0044152
def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]
synonym: "development during symbiotic interaction" RELATED [GOC:dph]
synonym: "development involved in symbiotic interaction" RELATED []
synonym: "development of symbiont during interaction with host" RELATED [GOC:dph]
synonym: "development of symbiont involved in interaction with host" RELATED []
synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "development on or near surface of other organism involved in symbiotic interaction" NARROW []
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0044113
name: obsolete development in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GO:jl, GOC:cc]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "development in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0044114
name: development of symbiont in host
namespace: biological_process
alt_id: GO:0044122
alt_id: GO:0044124
def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'biological process involved in interaction with host ; GO:0051701.
synonym: "development of symbiont in host intercellular space" NARROW []
synonym: "development of symbiont in host vascular tissue" NARROW []
is_a: GO:0044111 ! formation of structure involved in a symbiotic process

[Term]
id: GO:0044118
name: obsolete development of symbiont in host cell
namespace: biological_process
def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0044120
name: obsolete development of symbiont in host vacuole
namespace: biological_process
def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring in a host vacuole. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "development of symbiont in host organelle" BROAD []
is_obsolete: true

[Term]
id: GO:0044126
name: obsolete regulation of growth of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
is_obsolete: true

[Term]
id: GO:0044127
name: regulation of development of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'.
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
relationship: regulates GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044128
name: obsolete positive regulation of growth of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
is_obsolete: true

[Term]
id: GO:0044129
name: positive regulation of development of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of growth of symbiont in host ; GO:0044128'.
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process
relationship: positively_regulates GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044130
name: obsolete negative regulation of growth of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
is_obsolete: true

[Term]
id: GO:0044131
name: negative regulation of development of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of growth of symbiont in host ; GO:0044130'.
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process
relationship: negatively_regulates GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044132
name: obsolete development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: The reason for obsoletion is this term represents both a process and a component.
is_obsolete: true

[Term]
id: GO:0044133
name: obsolete growth of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0044134
name: obsolete development of symbiont on or near host phyllosphere
namespace: biological_process
def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: The reason for obsoletion is this term represents both a process and a component.
is_obsolete: true

[Term]
id: GO:0044135
name: obsolete growth of symbiont on or near host phyllosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
is_obsolete: true

[Term]
id: GO:0044136
name: obsolete development of symbiont on or near host rhizosphere
namespace: biological_process
def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: The reason for obsoletion is that this term represents both a process and a component
is_obsolete: true

[Term]
id: GO:0044137
name: obsolete growth of symbiont on or near host rhizosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0044138
name: obsolete modulation of development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: The reason for obsoletion is this term represents both a process and a component.
is_obsolete: true

[Term]
id: GO:0044139
name: obsolete modulation of growth of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
is_obsolete: true

[Term]
id: GO:0044140
name: obsolete negative regulation of growth of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
is_obsolete: true

[Term]
id: GO:0044141
name: obsolete negative regulation of development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: The reason for obsoletion is this term represents both a process and a component.
is_obsolete: true

[Term]
id: GO:0044142
name: obsolete positive regulation of growth of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
is_obsolete: true

[Term]
id: GO:0044143
name: obsolete positive regulation of development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: The reason for obsoletion is this term represents both a process and a component.
is_obsolete: true

[Term]
id: GO:0044144
name: obsolete modulation of growth of symbiont involved in interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
synonym: "modulation of growth of symbiont during interaction with host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0044145
name: modulation of formation of structure involved in a symbiotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'.
synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph]
synonym: "modulation of development of symbiont involved in interaction with host" RELATED []
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0044111 ! formation of structure involved in a symbiotic process

[Term]
id: GO:0044146
name: obsolete negative regulation of growth of symbiont involved in interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
synonym: "negative regulation of growth of symbiont during interaction with host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0044147
name: negative regulation of formation of structure involved in a symbiotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'.
synonym: "negative regulation of development of symbiont during interaction with host" RELATED [GOC:dph]
synonym: "negative regulation of development of symbiont involved in interaction with host" RELATED []
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0044111 ! formation of structure involved in a symbiotic process

[Term]
id: GO:0044148
name: obsolete positive regulation of growth of symbiont involved in interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent.
synonym: "positive regulation of growth of symbiont during interaction with host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0044149
name: positive regulation of formation of structure involved in a symbiotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'.
synonym: "positive regulation of development of symbiont during interaction with host" RELATED [GOC:dph]
synonym: "positive regulation of development of symbiont involved in interaction with host" RELATED []
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0044111 ! formation of structure involved in a symbiotic process

[Term]
id: GO:0044150
name: obsolete development of host on or near symbiont surface
namespace: biological_process
def: "OBSOLETE. The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: The reason for obsoletion is this term represents both a process and a component.
synonym: "development of organism on or near symbiont surface" EXACT []
is_obsolete: true

[Term]
id: GO:0044151
name: obsolete growth of host on or near symbiont surface
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "growth of organism on or near symbiont surface" EXACT []
is_obsolete: true

[Term]
id: GO:0044154
name: obsolete histone H3-K14 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 acetylation at K14" EXACT []
synonym: "histone H3K14 acetylation" EXACT []
is_obsolete: true

[Term]
id: GO:0044155
name: host caveola
namespace: cellular_component
def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:rph]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane

[Term]
id: GO:0044156
name: host cell junction
namespace: cellular_component
def: "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:rph]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0020002 ! host cell plasma membrane

[Term]
id: GO:0044157
name: host cell projection
namespace: cellular_component
def: "A prolongation or process extending from a host cell, e.g. a flagellum or axon." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044158
name: host cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044159
name: host thylakoid
namespace: cellular_component
def: "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:rph]
is_a: GO:0033647 ! host intracellular organelle

[Term]
id: GO:0044160
name: host thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of any host thylakoid." [GOC:rph]
is_a: GO:0033644 ! host cell membrane
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044159 ! host thylakoid

[Term]
id: GO:0044161
name: host cell cytoplasmic vesicle
namespace: cellular_component
def: "A vesicle formed of membrane or protein, found in the cytoplasm of a host cell." [GOC:rph]
subset: goslim_virus
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044162
name: host cell cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell cytoplasmic vesicle." [GOC:rph]
is_a: GO:0033644 ! host cell membrane
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044161 ! host cell cytoplasmic vesicle

[Term]
id: GO:0044163
name: host cytoskeleton
namespace: cellular_component
def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic host cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]
is_a: GO:0033647 ! host intracellular organelle

[Term]
id: GO:0044164
name: host cell cytosol
namespace: cellular_component
def: "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:jl]
synonym: "host cytosol" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044165
name: host cell endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GOC:jl]
subset: goslim_virus
synonym: "host endoplasmic reticulum" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044166
name: host cell endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the host cell endoplasmic reticulum." [GOC:jl]
synonym: "host endoplasmic reticulum lumen" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044167
name: host cell endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell endoplasmic reticulum." [GOC:jl]
synonym: "host endoplasmic reticulum membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0033645 ! host cell endomembrane system
relationship: part_of GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044168
name: host cell rough endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface." [GOC:jl]
synonym: "host rough endoplasmic reticulum" EXACT []
is_a: GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044169
name: host cell rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell rough endoplasmic reticulum." [GOC:jl]
synonym: "host rough endoplasmic reticulum membrane" EXACT []
is_a: GO:0044167 ! host cell endoplasmic reticulum membrane
relationship: part_of GO:0044168 ! host cell rough endoplasmic reticulum

[Term]
id: GO:0044170
name: host cell smooth endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface." [GOC:jl]
synonym: "host smooth endoplasmic reticulum" EXACT []
is_a: GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044171
name: host cell smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell smooth endoplasmic reticulum." [GOC:jl]
synonym: "host smooth endoplasmic reticulum membrane" EXACT []
is_a: GO:0044167 ! host cell endoplasmic reticulum membrane
relationship: part_of GO:0044170 ! host cell smooth endoplasmic reticulum

[Term]
id: GO:0044172
name: host cell endoplasmic reticulum-Golgi intermediate compartment
namespace: cellular_component
def: "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [GOC:jl, GOC:pr]
synonym: "host cell ER-Golgi intermediate compartment" EXACT []
synonym: "host ER-Golgi intermediate compartment" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044173
name: host cell endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system." [GOC:jl]
synonym: "host cell ER-Golgi intermediate compartment membrane" EXACT []
synonym: "host endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
synonym: "host ER-Golgi intermediate compartment membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044172 ! host cell endoplasmic reticulum-Golgi intermediate compartment

[Term]
id: GO:0044174
name: host cell endosome
namespace: cellular_component
def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation." [GOC:jl]
synonym: "host endosome" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044175
name: host cell endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell endosome." [GOC:jl]
synonym: "host endosome membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044174 ! host cell endosome

[Term]
id: GO:0044176
name: host cell filopodium
namespace: cellular_component
def: "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:jl]
synonym: "host filopodium" EXACT []
is_a: GO:0044157 ! host cell projection

[Term]
id: GO:0044177
name: host cell Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]
subset: goslim_virus
synonym: "host Golgi apparatus" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044178
name: host cell Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus." [GOC:jl]
synonym: "host Golgi membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0033645 ! host cell endomembrane system
relationship: part_of GO:0044177 ! host cell Golgi apparatus

[Term]
id: GO:0044179
name: hemolysis in another organism
namespace: biological_process
alt_id: GO:1990142
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl, PMID:21590705]
subset: goslim_chembl
synonym: "envenomation resulting in hemolysis in another organism" NARROW []
synonym: "envenomation resulting in hemolysis in other organism" NARROW []
synonym: "hemolysis in other organism" EXACT []
synonym: "hemolysis of cells in other organism" EXACT [GOC:bf]
synonym: "hemolysis of erythrocytes in other organism" EXACT []
synonym: "hemolysis of RBCs in other organism" EXACT []
synonym: "hemolysis of red blood cells in other organism" EXACT []
is_a: GO:0051715 ! cytolysis in another organism

[Term]
id: GO:0044180
name: filamentous growth of a unicellular organism
namespace: biological_process
def: "The process in which a unicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0044181
name: filamentous growth of a multicellular organism
namespace: biological_process
def: "The process in which a multicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis

[Term]
id: GO:0044182
name: filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0044183
name: protein folding chaperone
namespace: molecular_function
def: "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
synonym: "chaperone activity" BROAD []
synonym: "protein binding involved in protein folding" EXACT []
xref: Reactome:R-HSA-9018785 "RHOBTB2 binds GTP"
xref: Reactome:R-HSA-9855212 "SDHA binds to SDHB"
xref: Reactome:R-HSA-9865893 "MT-CYB is translated"
xref: Reactome:R-HSA-9866253 "apo-UQCRFS1 binds LYRM7"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0044184
name: host cell late endosome
namespace: cellular_component
def: "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [GOC:jl]
is_a: GO:0044174 ! host cell endosome

[Term]
id: GO:0044185
name: host cell late endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell late endosome." [GOC:jl]
is_a: GO:0044175 ! host cell endosome membrane
relationship: part_of GO:0044184 ! host cell late endosome

[Term]
id: GO:0044186
name: host cell lipid droplet
namespace: cellular_component
def: "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins." [GOC:jl]
synonym: "host cell lipid adiposome" EXACT []
synonym: "host cell lipid body" EXACT []
synonym: "host cell lipid particle" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044187
name: host cell lysosome
namespace: cellular_component
def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions." [GOC:jl]
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044188
name: host cell lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm." [GOC:jl]
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044187 ! host cell lysosome

[Term]
id: GO:0044189
name: obsolete host cell microsome
namespace: cellular_component
def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g." [GOC:jl]
comment: This term was obsoleted because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "host cell microsomal membrane" EXACT []
synonym: "host cell microsome" EXACT []
is_obsolete: true
consider: GO:0033648

[Term]
id: GO:0044190
name: host cell mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space." [GOC:jl]
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0033650 ! host cell mitochondrion

[Term]
id: GO:0044191
name: host cell mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope." [GOC:jl]
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044190 ! host cell mitochondrial envelope

[Term]
id: GO:0044192
name: host cell mitochondrial inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae." [GOC:jl]
is_a: GO:0044191 ! host cell mitochondrial membrane

[Term]
id: GO:0044193
name: host cell mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope." [GOC:jl]
is_a: GO:0039661 ! host organelle outer membrane
is_a: GO:0044191 ! host cell mitochondrial membrane

[Term]
id: GO:0044194
name: cytolytic granule
namespace: cellular_component
def: "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." [GOC:jl, PMID:11052265, PMID:12766758]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0044195
name: nucleoplasmic reticulum
namespace: cellular_component
def: "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport." [GOC:jl, PMID:17959832, PMID:9024685]
synonym: "nuclear channels" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0044196
name: host cell nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells." [GOC:jl]
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0044197
name: Rel homology domain binding
namespace: molecular_function
def: "Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT." [InterPro:IPR011539, Wikipedia:Rel_homology_domain]
synonym: "RHD binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0044198
name: zf-TRAF domain binding
namespace: molecular_function
def: "Binding to a TRAF-type zinc finger domain of a protein." [InterPro:IPR001293]
synonym: "TRAF-type zinc finger domain binding" EXACT []
synonym: "zinc finger TRAF-type domain binding" EXACT []
synonym: "zinc-finger-TRAF domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0044199
name: host cell nuclear envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [GOC:jl]
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0033645 ! host cell endomembrane system

[Term]
id: GO:0044200
name: host cell nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:jl]
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044199 ! host cell nuclear envelope

[Term]
id: GO:0044201
name: host cell nuclear inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope." [GOC:jl]
is_a: GO:0044200 ! host cell nuclear membrane

[Term]
id: GO:0044202
name: host cell nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes." [GOC:jl]
is_a: GO:0039661 ! host organelle outer membrane
is_a: GO:0044200 ! host cell nuclear membrane

[Term]
id: GO:0044203
name: host cell nuclear lamina
namespace: cellular_component
def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments." [GOC:jl]
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0044201 ! host cell nuclear inner membrane

[Term]
id: GO:0044204
name: host cell nuclear matrix
namespace: cellular_component
def: "The dense fibrillar network lying on the inner side of the host nuclear membrane." [GOC:jl]
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0044205
name: 'de novo' UMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen." [GOC:ecd, GOC:jl]
synonym: "'de novo' UMP biosynthesis" EXACT []
is_a: GO:0006222 ! UMP biosynthetic process

[Term]
id: GO:0044206
name: UMP salvage
namespace: biological_process
def: "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496]
synonym: "UMP biosynthesis via nucleoside salvage pathway" EXACT []
synonym: "UMP biosynthetic process via nucleoside salvage pathway" EXACT []
is_a: GO:0006222 ! UMP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage

[Term]
id: GO:0044207
name: translation initiation ternary complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl]
synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW []
synonym: "translation initiation (ternary) complex" EXACT []
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044208
name: 'de novo' AMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601]
is_a: GO:0006167 ! AMP biosynthetic process

[Term]
id: GO:0044209
name: AMP salvage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350]
synonym: "adenosine monophosphate salvage" EXACT []
synonym: "AMP biosynthetic process via salvage pathway" EXACT []
is_a: GO:0006167 ! AMP biosynthetic process
is_a: GO:0106380 ! purine ribonucleotide salvage

[Term]
id: GO:0044210
name: 'de novo' CTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916]
synonym: "'de novo' cytidine 5'-triphosphate biosynthetic process" EXACT []
is_a: GO:0006241 ! CTP biosynthetic process

[Term]
id: GO:0044211
name: CTP salvage
namespace: biological_process
def: "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935]
synonym: "CTP biosynthetic process via salvage pathway" EXACT []
synonym: "cytidine 5'-triphosphate salvage" EXACT []
is_a: GO:0006241 ! CTP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage

[Term]
id: GO:0044214
name: obsolete spanning component of plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "fully spanning plasma membrane" EXACT []
synonym: "transmembrane" RELATED [GOC:mah]
is_obsolete: true
replaced_by: GO:0005886

[Term]
id: GO:0044215
name: obsolete other organism
namespace: cellular_component
def: "OBSOLETE. A secondary organism with which the first organism is interacting." [GOC:jl]
comment: This term was obsoleted because it represents an organism, which is outside the scope of GO.
is_obsolete: true

[Term]
id: GO:0044216
name: obsolete other organism cell
namespace: cellular_component
def: "OBSOLETE. A cell of a secondary organism with which the first organism is interacting." [GOC:jl]
comment: This term was obsoleted because cell (and therefore 'other organism cell') was considered outside the scope of GO.
is_obsolete: true

[Term]
id: GO:0044217
name: other organism part
namespace: cellular_component
def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0044218
name: other organism cell membrane
namespace: cellular_component
alt_id: GO:0044279
def: "The cell membrane of a secondary organism with which the first organism is interacting." [GOC:jl]
synonym: "foreign membrane" RELATED []
synonym: "other organism membrane" BROAD []
is_a: GO:0044217 ! other organism part

[Term]
id: GO:0044219
name: host cell plasmodesma
namespace: cellular_component
def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell." [GOC:rph, PMID:16903353]
is_a: GO:0044156 ! host cell junction

[Term]
id: GO:0044220
name: host cell perinuclear region of cytoplasm
namespace: cellular_component
def: "The host cell cytoplasm situated near, or occurring around, the host nucleus." [GOC:rph]
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044221
name: host cell synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044222
name: anammoxosome
namespace: cellular_component
def: "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism." [GOC:dh, PMID:17993524, PMID:19682260]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044223
name: pirellulosome
namespace: cellular_component
def: "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm." [GOC:dh, PMID:19133117]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044224
name: juxtaparanode region of axon
namespace: cellular_component
def: "A region of an axon near a node of Ranvier that is between the paranode and internode regions." [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]
synonym: "juxta paranode axon" RELATED [NIF_Subcellular:sao1191319089]
synonym: "juxtaparanodal region" EXACT []
synonym: "juxtaparanode" EXACT []
xref: NIF_Subcellular:sao758620702
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0044225
name: apical pole of neuron
namespace: cellular_component
def: "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860]
xref: NIF_Subcellular:sao1186862860
is_a: GO:0060187 ! cell pole
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0044226
name: basal pole of neuron
namespace: cellular_component
def: "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges." [NIF_Subcellular:sao1186862860]
xref: NIF_Subcellular:sao1186862860
is_a: GO:0060187 ! cell pole
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0044227
name: methane-oxidizing organelle
namespace: cellular_component
def: "A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms." [GOC:dh]
synonym: "methane-oxidizing compartment" EXACT []
synonym: "methanotroph intracytoplasmic membrane-bound compartment" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044228
name: host cell surface
namespace: cellular_component
def: "The external part of the host cell wall and/or host plasma membrane." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044229
name: host cell periplasmic space
namespace: cellular_component
def: "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi)." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044230
name: host cell envelope
namespace: cellular_component
def: "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044231
name: host cell presynaptic membrane
namespace: cellular_component
alt_id: GO:0072556
def: "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:rph]
synonym: "host cell pre-synaptic membrane" EXACT []
synonym: "other organism pre-synaptic membrane" RELATED []
synonym: "other organism presynaptic membrane" RELATED []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane
relationship: part_of GO:0044221 ! host cell synapse

[Term]
id: GO:0044232
name: organelle membrane contact site
namespace: cellular_component
def: "A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880]
synonym: "inter-organelle junction" NARROW []
synonym: "interorganelle junction" NARROW []
synonym: "MCS" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0044233
name: mitochondria-associated endoplasmic reticulum membrane contact site
namespace: cellular_component
def: "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]
synonym: "endoplasmic reticulum-mitochondrion membrane contact site" EXACT []
synonym: "ER-mitochondrion membrane contact site" EXACT []
synonym: "MAM" RELATED []
synonym: "mitochondria-associated ER membrane" EXACT []
synonym: "mitochondria-associated membrane" EXACT []
synonym: "mitochondria-endoplasmic reticulum (ER) contact" EXACT [PMID:29870872]
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0044237
name: obsolete cellular metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
comment: The reason for obsoletion is that this term is now redundant with GO:0008152, metabolic process
synonym: "cellular metabolism" EXACT []
synonym: "intermediary metabolism" RELATED [GOC:mah]
is_obsolete: true
replaced_by: GO:0008152

[Term]
id: GO:0044238
name: primary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_pir
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "primary metabolism" EXACT []
xref: Wikipedia:Primary_metabolite
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044239
name: obsolete salivary polysaccharide catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/]
comment: The reason for obsoletion is that this term represents the location of a process, which should be captured by the relation 'occurs in'.
synonym: "salivary polysaccharide breakdown" EXACT []
synonym: "salivary polysaccharide catabolism" EXACT []
synonym: "salivary polysaccharide degradation" EXACT []
is_obsolete: true
consider: GO:0000272

[Term]
id: GO:0044241
name: lipid digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044242
name: obsolete cellular lipid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl]
comment: The reason for obsoletion is that this terms is redundant with GO:0016042
synonym: "cellular lipid breakdown" EXACT []
synonym: "cellular lipid catabolism" EXACT []
synonym: "cellular lipid degradation" EXACT []
is_obsolete: true
replaced_by: GO:0016042

[Term]
id: GO:0044245
name: polysaccharide digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044247
name: obsolete cellular polysaccharide catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells." [GOC:jl]
comment: This term was obsoleted because it is not different from its parent, polysaccharide catabolic process ; GO:0000272.
synonym: "cellular polysaccharide breakdown" EXACT []
synonym: "cellular polysaccharide catabolism" EXACT []
synonym: "cellular polysaccharide degradation" EXACT []
is_obsolete: true
replaced_by: GO:0000272

[Term]
id: GO:0044248
name: cellular catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]
synonym: "cellular breakdown" EXACT []
synonym: "cellular catabolism" EXACT []
synonym: "cellular degradation" EXACT []
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0044249
name: obsolete cellular biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]
comment: The reason for obsoletion is that this term is now redundant with GO:0009058, biosynthetic process
synonym: "cellular anabolism" EXACT []
synonym: "cellular biosynthesis" EXACT []
synonym: "cellular formation" EXACT []
synonym: "cellular synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0009058

[Term]
id: GO:0044250
name: negative regulation of metabolic activity involved in hibernation
namespace: biological_process
def: "The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation." [GOC:jl, Wikipedia:Hibernation]
synonym: "down regulation of metabolic activity during hibernation" RELATED []
synonym: "down-regulation of metabolic activity during hibernation" RELATED []
synonym: "downregulation of metabolic activity during hibernation" RELATED []
synonym: "inhibition of metabolic activity during hibernation" NARROW []
synonym: "negative regulation of metabolic activity during hibernation" RELATED [GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
relationship: part_of GO:0042750 ! hibernation

[Term]
id: GO:0044251
name: obsolete protein catabolic process by pepsin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/]
comment: The reason for obsoletion is that this term represents a specific gene product.
synonym: "protein breakdown by pepsin" EXACT []
synonym: "protein degradation by pepsin" EXACT []
is_obsolete: true
consider: GO:0030163

[Term]
id: GO:0044255
name: obsolete cellular lipid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]
comment: The reason for obsoletion is that this term is redundant to GO:0006629
synonym: "cellular lipid metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006629

[Term]
id: GO:0044256
name: protein digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044258
name: intestinal lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, PMID:7018485]
synonym: "intestinal lipid breakdown" EXACT []
synonym: "intestinal lipid catabolism" EXACT []
synonym: "intestinal lipid degradation" EXACT []
is_a: GO:0016042 ! lipid catabolic process

[Term]
id: GO:0044260
name: obsolete cellular macromolecule metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [GOC:mah]
comment: This term was obsoleted because it is not different from its parent, macromolecule metabolic process ; GO:0043170.
synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0043170

[Term]
id: GO:0044262
name: obsolete cellular carbohydrate metabolic process
namespace: biological_process
alt_id: GO:0006092
def: "OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
comment: This term was obsoleted because it is not different from its parent, carbohydrate metabolic process ; GO:0005975.
synonym: "cellular carbohydrate metabolism" EXACT []
synonym: "main pathways of carbohydrate metabolic process" NARROW []
synonym: "main pathways of carbohydrate metabolism" NARROW []
is_obsolete: true
replaced_by: GO:0005975

[Term]
id: GO:0044264
name: obsolete cellular polysaccharide metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl]
comment: This term was obsoleted because it is not different from its parent, polysaccharide metabolic process ; GO:0005976.
synonym: "cellular glycan metabolic process" EXACT []
synonym: "cellular glycan metabolism" EXACT []
synonym: "cellular polysaccharide metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0005976

[Term]
id: GO:0044265
name: obsolete cellular macromolecule catabolic process
namespace: biological_process
alt_id: GO:0034962
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [GOC:jl]
comment: This term was obsoleted because it is not different from its parent, macromolecule catabolic process ; GO:0009057.
synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule breakdown" EXACT []
synonym: "cellular macromolecule catabolism" EXACT []
synonym: "cellular macromolecule degradation" EXACT []
is_obsolete: true
replaced_by: GO:0009057

[Term]
id: GO:0044269
name: glycerol ether catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl]
synonym: "glycerol ether breakdown" EXACT []
synonym: "glycerol ether catabolism" EXACT []
synonym: "glycerol ether degradation" EXACT []
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0044270
name: obsolete cellular nitrogen compound catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009056

[Term]
id: GO:0044271
name: obsolete cellular nitrogen compound biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009058

[Term]
id: GO:0044272
name: sulfur compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
synonym: "sulfur biosynthesis" NARROW []
synonym: "sulfur biosynthetic process" NARROW []
synonym: "sulfur compound anabolism" EXACT []
synonym: "sulfur compound biosynthesis" EXACT []
synonym: "sulfur compound formation" EXACT []
synonym: "sulfur compound synthesis" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0044273
name: sulfur compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
synonym: "sulfur catabolic process" NARROW []
synonym: "sulfur catabolism" NARROW []
synonym: "sulfur compound breakdown" EXACT []
synonym: "sulfur compound catabolism" EXACT []
synonym: "sulfur compound degradation" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044275
name: obsolete cellular carbohydrate catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
comment: This term was obsoleted because it is not different from its parent, carbohydrate catabolic process ; GO:0016052.
synonym: "cellular carbohydrate breakdown" EXACT []
synonym: "cellular carbohydrate catabolism" EXACT []
synonym: "cellular carbohydrate degradation" EXACT []
is_obsolete: true
replaced_by: GO:0016052

[Term]
id: GO:0044277
name: cell wall disassembly
namespace: biological_process
alt_id: GO:0060871
def: "A process that results in the breakdown of the cell wall." [GOC:jl]
synonym: "cellular cell wall disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0044278
name: disruption of cell wall in another organism
namespace: biological_process
def: "The disruption of the cell wall of another organism, leading to damage or temporary subversion of the cell wall." [PMID:36738900]
comment: This process can occur in symbiotic and non-symbiotic relations; example of a non-symbiotic relation is waprin and Amwaprin of bees, that damages the cell wall of bacterial and fungal cells.
synonym: "cell wall disruption in another organism" EXACT []
synonym: "cell wall disruption in other organism" EXACT []
is_a: GO:0140975 ! disruption of cellular anatomical structure in another organism

[Term]
id: GO:0044280
name: subplasmalemmal coating
namespace: cellular_component
def: "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier." [NIF_Subcellular:sao1938587839]
xref: NIF_Subcellular:sao1938587839
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane

[Term]
id: GO:0044281
name: small molecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "small molecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044282
name: small molecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
synonym: "small molecule catabolism" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0044283
name: small molecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "small molecule biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0044284
name: mitochondrial crista junction
namespace: cellular_component
def: "A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane." [GOC:mcc, PMID:21944719, PMID:21987634, PMID:22009199]
synonym: "crista junction" EXACT []
synonym: "cristae junction" EXACT []
is_a: GO:0044232 ! organelle membrane contact site
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0044286
name: peg and socket contact
namespace: cellular_component
def: "A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells." [GOC:tfm, NIF_Subcellular:sao1943947957, PMID:12883993, PMID:16166562, PMID:17591898]
synonym: "ball and socket contact" EXACT [GOC:tfm, PMID:17591898]
xref: NIF_Subcellular:sao1943947957
is_a: GO:0044291 ! cell-cell contact zone

[Term]
id: GO:0044288
name: puncta adhaerentia
namespace: cellular_component
def: "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells." [NIF_Subcellular:sao257629430]
xref: NIF_Subcellular:sao257629430
is_a: GO:0005915 ! zonula adherens

[Term]
id: GO:0044289
name: mitochondrial inner-outer membrane contact site
namespace: cellular_component
alt_id: GO:0044285
def: "Sites of close apposition of the inner and outer mitochondrial membrane." [PMID:22009199]
synonym: "bridge contact site" RELATED []
synonym: "contact site" BROAD []
is_a: GO:0044232 ! organelle membrane contact site
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0044290
name: mitochondrial intracristal space
namespace: cellular_component
def: "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space." [NIF_Subcellular:sao508958414]
xref: NIF_Subcellular:sao508958414
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0044291
name: cell-cell contact zone
namespace: cellular_component
def: "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018]
synonym: "cell cell contact zone" EXACT []
xref: NIF_Subcellular:sao1299635018
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0044292
name: dendrite terminus
namespace: cellular_component
def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134]
synonym: "dendrite terminal" EXACT []
synonym: "dendrite terminal specialization" RELATED []
synonym: "terminal specialization" RELATED [NIF_Subcellular:sao28175134]
synonym: "terminal specialization of a dendrite" EXACT []
xref: NIF_Subcellular:sao28175134
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0044293
name: dendriole
namespace: cellular_component
def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904]
xref: NIF_Subcellular:sao28175134
xref: NIF_Subcellular:sao295057932
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0044294
name: dendritic growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell dendrite." [GOC:jl]
synonym: "dendrite growth cone" EXACT []
xref: NIF_Subcellular:sao1594955670
is_a: GO:0030426 ! growth cone
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0044295
name: axonal growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
synonym: "axon growth cone" EXACT []
xref: NIF_Subcellular:sao1594955670
xref: NIF_Subcellular:sao203987954
is_a: GO:0030426 ! growth cone

[Term]
id: GO:0044296
name: dendritic tuft
namespace: cellular_component
def: "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance." [NIF_Subcellular:sao1340260079]
synonym: "dendrite tuft" EXACT []
xref: NIF_Subcellular:sao1340260079
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0044297
name: cell body
namespace: cellular_component
def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
synonym: "cell soma" EXACT []
xref: FBbt:00005107
xref: FMA:67301
xref: Wikipedia:Cell_body
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0044298
name: cell body membrane
namespace: cellular_component
def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd]
synonym: "cell soma membrane" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0044297 ! cell body

[Term]
id: GO:0044299
name: C-fiber
namespace: cellular_component
def: "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated." [NIF_Subcellular:nlx_subcell_20090210]
synonym: "C-fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090210
is_a: GO:0030424 ! axon

[Term]
id: GO:0044300
name: cerebellar mossy fiber
namespace: cellular_component
def: "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations." [NIF_Subcellular:nlx_subcell_20090209]
synonym: "cerebellar mossy fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090209
is_a: GO:0030424 ! axon

[Term]
id: GO:0044301
name: climbing fiber
namespace: cellular_component
def: "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203]
synonym: "climbing fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090203
is_a: GO:0030424 ! axon

[Term]
id: GO:0044302
name: dentate gyrus mossy fiber
namespace: cellular_component
def: "Hippocampal mossy fiber produced by dentate gyrus granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709]
synonym: "dentate gyrus mossy fibre" EXACT []
synonym: "granule cell axon" BROAD []
xref: NIF_Subcellular:nlx_subcell_20090601
is_a: GO:0097457 ! hippocampal mossy fiber

[Term]
id: GO:0044303
name: axon collateral
namespace: cellular_component
def: "Any of the smaller branches of an axon that emanate from the main axon cylinder." [NIF_Subcellular:sao1470140754]
xref: NIF_Subcellular:sao1470140754
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0044304
name: main axon
namespace: cellular_component
def: "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044]
synonym: "axon shaft" RELATED [PMID:11264310, PMID:24312009]
synonym: "axon trunk" EXACT []
synonym: "axonal shaft" RELATED [PMID:11264310, PMID:24312009]
xref: NIF_Subcellular:sao1596975044
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0044305
name: calyx of Held
namespace: cellular_component
def: "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system." [NIF_Subcellular:sao1684283879, PMID:11823805]
xref: NIF_Subcellular:sao1684283879
is_a: GO:0043679 ! axon terminus

[Term]
id: GO:0044306
name: neuron projection terminus
namespace: cellular_component
def: "The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl]
synonym: "nerve terminal" RELATED [PMID:25972809, PMID:9650842]
synonym: "neuron projection terminal" EXACT []
synonym: "neuron terminal specialization" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0044307
name: dendritic branch
namespace: cellular_component
def: "A dendrite arising from another dendrite." [GOC:aruk, GOC:bc, NIF_Subcellular:sao884265541]
synonym: "dendrite branch" EXACT []
synonym: "secondary dendrite" NARROW [PMID:25431552]
xref: NIF_Subcellular:sao884265541
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0044308
name: axonal spine
namespace: cellular_component
def: "A spine that originates from the axon, usually from the initial segment." [NIF_Subcellular:sao18239917]
synonym: "axon spine" EXACT []
xref: NIF_Subcellular:sao18239917
is_a: GO:0044309 ! neuron spine
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0044309
name: neuron spine
namespace: cellular_component
def: "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102]
synonym: "spine" BROAD []
xref: NIF_Subcellular:sao1145756102
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0044310
name: osmiophilic body
namespace: cellular_component
def: "A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito." [GOC:jl, PMID:18086189]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0044311
name: exoneme
namespace: cellular_component
def: "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte." [GOC:jl, PMID:18083092, PMID:18083098]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0044312
name: crystalloid
namespace: cellular_component
def: "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation." [GOC:jl, PMID:19932717]
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044313
name: protein K6-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein." [GOC:sp]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0044314
name: protein K27-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein." [PMID:19345326]
synonym: "protein K27-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0044315
name: protein secretion by the type VII secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system." [PMID:17922044, PMID:19876390]
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0044316
name: cone cell pedicle
namespace: cellular_component
def: "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL)." [PMID:10939333]
synonym: "cone pedicle" EXACT []
is_a: GO:0043679 ! axon terminus

[Term]
id: GO:0044317
name: rod spherule
namespace: cellular_component
def: "A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body." [PMID:26930660]
synonym: "rod cell spherule" EXACT []
synonym: "rod photoreceptor spherule" EXACT []
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0044318
name: obsolete L-aspartate:fumarate oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate." [PMID:20149100]
comment: This term was obsoleted because it represents the same activity as L-aspartate oxidase activity ; GO:0008734, with a different electron acceptor.
is_obsolete: true
replaced_by: GO:0008734

[Term]
id: GO:0044319
name: wound healing, spreading of cells
namespace: biological_process
def: "The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface." [GOC:jl]
synonym: "cell migration involved in wound healing epiboly" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0090505 ! epiboly involved in wound healing

[Term]
id: GO:0044320
name: cellular response to leptin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism." [GOC:yaf]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0044321 ! response to leptin

[Term]
id: GO:0044321
name: response to leptin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]." [GOC:yaf]
synonym: "response to leptin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0044322
name: endoplasmic reticulum quality control compartment
namespace: cellular_component
def: "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins." [PMID:11408579]
synonym: "ER quality control compartment" EXACT []
synonym: "ER-derived quality control compartment" RELATED []
synonym: "ERQC" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0044323
name: retinoic acid-responsive element binding
namespace: molecular_function
def: "Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind." [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671]
synonym: "RARE binding" EXACT []
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0044324
name: obsolete regulation of transcription involved in anterior/posterior axis specification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis." [GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0044325
name: transmembrane transporter binding
namespace: molecular_function
def: "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]
subset: goslim_chembl
synonym: "ion channel binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0044326
name: dendritic spine neck
namespace: cellular_component
def: "Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine." [GOC:nln]
synonym: "neck" BROAD [NIF_Subcellular:sao1642908940]
synonym: "pedicle" RELATED [NIF_Subcellular:sao1642908940]
synonym: "spine neck" BROAD [NIF_Subcellular:sao1642908940]
xref: NIF_Subcellular:sao1642908940
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0044327
name: dendritic spine head
namespace: cellular_component
def: "Distal part of the dendritic spine, that carries the post-synaptic density." [GOC:BHF, GOC:nln, GOC:rl]
synonym: "spine head" BROAD [NIF_Subcellular:sao952643730]
xref: NIF_Subcellular:sao952643730
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0044328
name: obsolete canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0010595
consider: GO:0060070

[Term]
id: GO:0044329
name: obsolete canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0022409
consider: GO:0060070

[Term]
id: GO:0044330
name: obsolete canonical Wnt signaling pathway involved in positive regulation of wound healing
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of wound healing" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of wound healing" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of wound healing" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060070
consider: GO:0090303

[Term]
id: GO:0044331
name: cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970]
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0044332
name: obsolete Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0009950
consider: GO:0016055

[Term]
id: GO:0044333
name: obsolete Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT []
synonym: "Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling]
is_obsolete: true
consider: GO:0016055
consider: GO:0048546

[Term]
id: GO:0044334
name: obsolete canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0010718
consider: GO:0060070

[Term]
id: GO:0044335
name: obsolete canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0014033
consider: GO:0060070

[Term]
id: GO:0044336
name: canonical Wnt signaling pathway involved in negative regulation of apoptotic process
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]
synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis" NARROW []
synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis" EXACT [GOC:mah]
is_a: GO:0060070 ! canonical Wnt signaling pathway
relationship: part_of GO:0043066 ! negative regulation of apoptotic process

[Term]
id: GO:0044337
name: canonical Wnt signaling pathway involved in positive regulation of apoptotic process
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis" NARROW []
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of apoptotic process" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
relationship: part_of GO:0043065 ! positive regulation of apoptotic process

[Term]
id: GO:0044338
name: canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
relationship: part_of GO:0072497 ! mesenchymal stem cell differentiation

[Term]
id: GO:0044339
name: obsolete canonical Wnt signaling pathway involved in osteoblast differentiation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM pathway.
synonym: "canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0001649
consider: GO:0060070

[Term]
id: GO:0044340
name: obsolete canonical Wnt signaling pathway involved in regulation of cell proliferation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation." [GOC:BHF, GOC:jl]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in regulation of cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in regulation of cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in regulation of cell proliferation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0042127
consider: GO:0060070

[Term]
id: GO:0044341
name: sodium-dependent phosphate transport
namespace: biological_process
def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]
is_a: GO:0006817 ! phosphate ion transport

[Term]
id: GO:0044342
name: type B pancreatic cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf]
synonym: "pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "pancreatic beta cell proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0044343
name: obsolete canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" RELATED []
synonym: "canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060070
consider: GO:0061469

[Term]
id: GO:0044344
name: cellular response to fibroblast growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf]
synonym: "cellular response to FGF stimulus" EXACT []
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071774 ! response to fibroblast growth factor

[Term]
id: GO:0044345
name: stromal-epithelial cell signaling involved in prostate gland development
namespace: biological_process
def: "The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development." [GOC:jl, GOC:yaf]
synonym: "stromal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0044346
name: fibroblast apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]
synonym: "fibroblast apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0044347
name: cell wall polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides." [GOC:mengo_curators]
synonym: "cell wall polysaccharide breakdown" EXACT [GOC:mah]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0016998 ! cell wall macromolecule catabolic process

[Term]
id: GO:0044348
name: plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall." [GOC:mengo_curators]
synonym: "plant-type cell wall polysaccharide breakdown" EXACT [GOC:mah]
is_a: GO:0044347 ! cell wall polysaccharide catabolic process
is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process

[Term]
id: GO:0044349
name: DNA excision
namespace: biological_process
def: "The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised." [GOC:jl]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0044350
name: micropinocytosis
namespace: biological_process
alt_id: GO:1902540
def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm." [PMID:14731589, PMID:14732047]
synonym: "clathrin-independent pinocytosis" BROAD []
synonym: "single-organism micropinocytosis" RELATED []
is_a: GO:0006907 ! pinocytosis

[Term]
id: GO:0044351
name: macropinocytosis
namespace: biological_process
alt_id: GO:1902538
def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047]
synonym: "clathrin-independent pinocytosis" BROAD []
synonym: "single-organism macropinocytosis" RELATED []
is_a: GO:0006907 ! pinocytosis

[Term]
id: GO:0044352
name: pinosome
namespace: cellular_component
def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis." [PMID:14731589, PMID:14732047]
synonym: "pinocytic vesicle" EXACT [NIF_Subcellular:sao1925368674]
xref: NIF_Subcellular:sao1925368674
is_a: GO:0005768 ! endosome

[Term]
id: GO:0044353
name: micropinosome
namespace: cellular_component
def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis." [PMID:14731589, PMID:14732047]
is_a: GO:0044352 ! pinosome

[Term]
id: GO:0044354
name: macropinosome
namespace: cellular_component
def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis." [PMID:14732047]
is_a: GO:0044352 ! pinosome

[Term]
id: GO:0044355
name: clearance of foreign intracellular DNA
namespace: biological_process
alt_id: GO:0044356
def: "A defense process that protects an organism from invading foreign DNA." [GO:jl, PMID:20062055]
synonym: "clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine" NARROW []
is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids

[Term]
id: GO:0044357
name: regulation of rRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs." [GOC:jl]
synonym: "regulation of ribosomal RNA stability" EXACT []
is_a: GO:0043487 ! regulation of RNA stability
is_a: GO:1902374 ! regulation of rRNA catabolic process

[Term]
id: GO:0044358
name: envenomation resulting in hemorrhagic damage in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism." [PMID:10441379, PMID:20614020]
synonym: "envenomation resulting in hemorrhagic damage to other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044359
name: modulation of molecular function in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the function of proteins in a second organism." [GOC:jl]
synonym: "modulation of molecular function in other organism" EXACT []
is_a: GO:0035821 ! modulation of process of another organism

[Term]
id: GO:0044360
name: modulation of voltage-gated potassium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl]
synonym: "modulation of voltage-gated potassium channel activity in other organism" EXACT []
is_a: GO:0044363 ! modulation of potassium channel activity in another organism

[Term]
id: GO:0044361
name: negative regulation of voltage-gated potassium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of voltage-gated potassium channel activity in other organism" EXACT []
is_a: GO:0044360 ! modulation of voltage-gated potassium channel activity in another organism
is_a: GO:0044362 ! negative regulation of molecular function in another organism

[Term]
id: GO:0044362
name: negative regulation of molecular function in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl]
subset: gocheck_do_not_annotate
synonym: "negative regulation of molecular function in other organism" EXACT []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0044359 ! modulation of molecular function in another organism

[Term]
id: GO:0044363
name: modulation of potassium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism." [GOC:jl]
synonym: "modulation of potassium channel activity in other organism" EXACT []
is_a: GO:0044561 ! modulation of ion channel activity in another organism

[Term]
id: GO:0044364
name: obsolete disruption of cells of another organism
namespace: biological_process
def: "OBSOLETE. A process in which an organism has a negative effect on the functioning of the second organism's cells." [GOC:jl]
comment: This term was obsoleted because it was not specific enough.
synonym: "disruption of cells of other organism" EXACT []
is_obsolete: true
consider: GO:0031640
consider: GO:0061844

[Term]
id: GO:0044365
name: envenomation resulting in modulation of platelet aggregation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in modulation of platelet aggregation in other organism" EXACT []
synonym: "envenomation resulting in regulation of platelet aggregation in other organism" EXACT []
is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in another organism

[Term]
id: GO:0044373
name: cytokinin binding
namespace: molecular_function
def: "Binding to a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators." [GOC:jl]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0044374
name: sequence-specific DNA binding, bending
namespace: molecular_function
def: "The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw]
synonym: "DNA bending involving sequence-specific DNA binding" EXACT []
is_a: GO:0008301 ! DNA binding, bending
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0044375
name: regulation of peroxisome size
namespace: biological_process
def: "Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl]
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0044376
name: obsolete RNA polymerase II complex import to nucleus
namespace: biological_process
alt_id: GO:0098738
def: "OBSOLETE. The directed movement of the DNA-directed RNA polymerase II core complex from the cytoplasm into the nucleus." [GOC:dos, GOC:jl]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "DNA-directed RNA polymerase II core complex import into nucleus" EXACT [GO:0098738]
synonym: "DNA-directed RNA polymerase II core complex localization to nucleus" EXACT []
synonym: "RNA polymerase II complex import into nucleus" EXACT []
synonym: "RNA polymerase II complex localisation to nucleus" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0044377
name: RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending
namespace: molecular_function
def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:pg]
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending" RELATED []
synonym: "RNA polymerase II promoter proximal region sequence-specific DNA binding, bending" RELATED []
synonym: "RNA polymerase II proximal promoter region sequence-specific DNA binding, bending" RELATED []
synonym: "RNA polymerase II proximal promoter sequence-specific DNA binding, bending" RELATED []
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
is_a: GO:0044374 ! sequence-specific DNA binding, bending

[Term]
id: GO:0044378
name: non-sequence-specific DNA binding, bending
namespace: molecular_function
def: "The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw, PMID:20123079]
synonym: "DNA bending involving non-sequence-specific DNA binding" EXACT []
is_a: GO:0008301 ! DNA binding, bending

[Term]
id: GO:0044379
name: protein localization to actin cortical patch
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, an actin cortical patch." [GOC:mah, PMID:21620704]
synonym: "protein localisation to actin cortical patch" EXACT [GOC:mah]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:1903119 ! protein localization to actin cytoskeleton

[Term]
id: GO:0044380
name: protein localization to cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl]
synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0044381
name: glucose import in response to insulin stimulus
namespace: biological_process
def: "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus." [GOC:BHF, PMID:19079291]
synonym: "cellular glucose import in response to insulin stimulus" EXACT []
is_a: GO:0046323 ! D-glucose import
relationship: part_of GO:0032869 ! cellular response to insulin stimulus

[Term]
id: GO:0044382
name: CLRC complex localization to heterochromatin
namespace: biological_process
def: "The process by which a CLRC complex is transported to, or maintained in, heterochromatin. CLRC complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation." [GOC:jl]
synonym: "CLRC ubiquitin ligase complex localisation to heterochromatin" EXACT [GOC:mah]
synonym: "CLRC ubiquitin ligase complex localization to heterochromatin" EXACT []
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0097355 ! protein localization to heterochromatin

[Term]
id: GO:0044383
name: host chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell." [GOC:jl]
is_a: GO:0033647 ! host intracellular organelle

[Term]
id: GO:0044384
name: host outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell." [GOC:jl]
comment: This term covers the outer membrane of the host cell envelope or the outer membrane of a host organelle. For the outer layer of the host cell envelope specifically, see host cell outer membrane ; GO:0039662.
synonym: "host cell outer membrane" RELATED [GOC:bf]
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0044385
name: obsolete integral to membrane of host cell
namespace: cellular_component
def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell." [GOC:jl]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0033644

[Term]
id: GO:0044386
name: obsolete integral to host endoplasmic reticulum membrane
namespace: cellular_component
def: "OBSOLETE. Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell." [GOC:jl]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0044167

[Term]
id: GO:0044387
name: negative regulation of protein kinase activity by regulation of protein phosphorylation
namespace: biological_process
def: "The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase." [GOC:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0006469 ! negative regulation of protein kinase activity

[Term]
id: GO:0044388
name: small protein activating enzyme binding
namespace: molecular_function
def: "Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0044389
name: ubiquitin-like protein ligase binding
namespace: molecular_function
def: "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]
synonym: "E3 protein ligase binding" EXACT []
synonym: "small conjugating protein ligase binding" EXACT [GOC:dph]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0044390
name: ubiquitin-like protein conjugating enzyme binding
namespace: molecular_function
def: "Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme." [GOC:jl]
synonym: "E2 protein ligase binding" EXACT []
synonym: "small protein conjugating enzyme binding" EXACT [GOC:dph]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0044391
name: ribosomal subunit
namespace: cellular_component
def: "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl]
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005840 ! ribosome

[Term]
id: GO:0044392
name: obsolete peptidyl-lysine malonylation
namespace: biological_process
def: "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568]
comment: This term was obsoleted because it represents a molecular function.
synonym: "lysine malonylation" EXACT [PMID:21908771]
is_obsolete: true

[Term]
id: GO:0044393
name: microspike
namespace: cellular_component
def: "A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735]
comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. See also 'filopodium ; GO:0030175'.
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0044394
name: protein malonylation
namespace: biological_process
def: "The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [GOC:sp]
subset: gocheck_obsoletion_candidate
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0044395
name: protein targeting to vacuolar membrane
namespace: biological_process
def: "The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein." [GOC:jl]
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:1903778 ! protein localization to vacuolar membrane

[Term]
id: GO:0044396
name: actin cortical patch organization
namespace: biological_process
def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis." [GOC:jl]
synonym: "actin cortical patch organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0030866 ! cortical actin cytoskeleton organization

[Term]
id: GO:0044397
name: obsolete actin cortical patch internalization
namespace: biological_process
def: "OBSOLETE. A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell." [GOC:mah]
comment: The reason for obsoletion is that it represents a phenotype.
is_obsolete: true
replaced_by: GO:0006897

[Term]
id: GO:0044398
name: envenomation resulting in induction of edema in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation." [GOC:jl, PMID:20562011]
synonym: "envenomation resulting in induction of edema in other organism" EXACT []
synonym: "envenomation resulting in induction of oedema in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044399
name: multi-species biofilm formation
namespace: biological_process
alt_id: GO:0044400
alt_id: GO:0044401
alt_id: GO:0090607
alt_id: GO:0090608
def: "A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb]
synonym: "multi-species biofilm formation in or on host organism" NARROW []
synonym: "multi-species biofilm formation on inanimate substrate" NARROW []
synonym: "multi-species submerged biofilm formation" NARROW []
synonym: "multi-species surface biofilm formation" RELATED []
is_a: GO:0042710 ! biofilm formation
is_a: GO:0044403 ! biological process involved in symbiotic interaction

[Term]
id: GO:0044402
name: obsolete competition with other organism
namespace: biological_process
def: "OBSOLETE. Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community." [GOC:cc]
comment: This term was obsoleted because it is outside the scope of GO.
synonym: "competition with another organism" EXACT [GOC:bf]
synonym: "interspecies competition" BROAD []
is_obsolete: true

[Term]
id: GO:0044403
name: biological process involved in symbiotic interaction
namespace: biological_process
alt_id: GO:0043298
alt_id: GO:0044404
alt_id: GO:0072519
alt_id: GO:0085031
def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, PMID:31257129]
subset: goslim_chembl
synonym: "commensalism" NARROW []
synonym: "host-pathogen interaction" NARROW []
synonym: "parasitism" NARROW []
synonym: "symbiosis" RELATED []
synonym: "symbiosis, encompassing mutualism through parasitism" RELATED []
synonym: "symbiotic interaction" RELATED []
synonym: "symbiotic interaction between host and organism" RELATED []
synonym: "symbiotic interaction between organisms" RELATED []
synonym: "symbiotic interaction between species" RELATED []
synonym: "symbiotic process" RELATED []
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0044405
name: obsolete detection of host
namespace: biological_process
def: "OBSOLETE. The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: The reason for obsoletion is that the term is not a specific process and there are no annotations.
synonym: "recognition of host" EXACT []
is_obsolete: true

[Term]
id: GO:0044406
name: adhesion of symbiont to host
namespace: biological_process
alt_id: GO:0051825
alt_id: GO:0051856
def: "The attachment of a symbiont to its host via either adhesion molecules, general stickiness, or other mechanisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:cc, GOC:dos, GOC:jl]
synonym: "adhesion to host" RELATED []
synonym: "adhesion to other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "adhesion to other organism involved in symbiotic interaction" EXACT []
synonym: "host adhesion" NARROW []
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044407
name: single-species biofilm formation in or on host organism
namespace: biological_process
def: "A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0044408
name: obsolete growth or development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc]
synonym: "growth or development of organism on or near host surface" EXACT []
synonym: "growth or development of symbiont on or near host" EXACT []
is_obsolete: true

[Term]
id: GO:0044409
name: symbiont entry into host
namespace: biological_process
alt_id: GO:0030260
alt_id: GO:0044411
alt_id: GO:0051806
alt_id: GO:0051828
alt_id: GO:0051830
alt_id: GO:0075052
alt_id: GO:0085027
alt_id: GO:0085028
def: "Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:vw]
subset: goslim_virus
synonym: "entry into cell of other organism during symbiotic interaction" NARROW [GOC:tb]
synonym: "entry into cell of other organism involved in symbiotic interaction" RELATED []
synonym: "entry into host" EXACT []
synonym: "entry into host cell via penetration peg" NARROW []
synonym: "entry into host through host barriers" RELATED []
synonym: "entry into host via a specialized structure during symbiotic interaction" NARROW []
synonym: "entry into host via enzymatic degradation of host anatomical structure" NARROW []
synonym: "entry into host via enzymatic degradation of host cuticle" NARROW []
synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "entry into other organism involved in symbiotic interaction" RELATED []
synonym: "host invasion" EXACT []
synonym: "host penetration" EXACT [GOC:vw]
synonym: "invasion into host" EXACT []
synonym: "invasion into other organism" RELATED []
synonym: "invasion of host" EXACT []
synonym: "invasion of other organism" RELATED []
synonym: "invasive growth" RELATED []
synonym: "other organism invasion" RELATED []
synonym: "penetration into host" EXACT [GOC:vw]
synonym: "penetration into host via a specialized structure" NARROW [GOC:vw]
synonym: "penetration into host via a specialized structure during symbiotic interaction" NARROW [GOC:vw]
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044410
name: obsolete entry into host through natural portals
namespace: biological_process
alt_id: GO:0051829
def: "OBSOLETE. Penetration by a symbiont into a host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This is an unnecessary grouping term.
synonym: "entry into other organism through natural portals during symbiotic interaction" RELATED [GOC:tb]
synonym: "entry into other organism through natural portals involved in symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0044412
name: obsolete growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development of organism within host" EXACT []
synonym: "growth or development of symbiont in host" EXACT []
synonym: "growth or development of symbiont within host" EXACT []
synonym: "invasive growth" BROAD []
is_obsolete: true
consider: GO:0044114
consider: GO:0051701

[Term]
id: GO:0044414
name: symbiont-mediated suppression of host defenses
namespace: biological_process
alt_id: GO:0051833
alt_id: GO:0052037
alt_id: GO:0052261
def: "A process in which a symbiont interferes with, inhibits or disrupts the normal execution of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators]
synonym: "down regulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "down regulation by symbiont of host defense response" EXACT []
synonym: "down-regulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by symbiont of host defense response" EXACT []
synonym: "downregulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by symbiont of host defense response" EXACT []
synonym: "inhibition by organism of defense response of other organism during symbiotic interaction" NARROW []
synonym: "inhibition by symbiont of host defense response" NARROW []
synonym: "negative regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation by organism of defense response of other organism involved in symbiotic interaction" EXACT []
synonym: "negative regulation by symbiont of host defense response" EXACT []
synonym: "negative regulation of host defenses" EXACT []
synonym: "suppression of defense response of other organism" EXACT []
synonym: "suppression of defense response of other organism involved in symbiotic interaction" RELATED []
synonym: "suppression of defenses of other organism involved in symbiotic interaction" BROAD []
synonym: "suppression of host defense response" EXACT []
synonym: "suppression of host defenses by symbiont" EXACT []
is_a: GO:0030682 ! symbiont-mediated perturbation of host defenses

[Term]
id: GO:0044416
name: obsolete induction by symbiont of host defense response
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because there is no evidece that this process exists.
synonym: "activation by symbiont of host defense response" EXACT []
synonym: "activation of host defense response" EXACT []
synonym: "induction by organism of defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by organism of defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of host defense response" RELATED []
synonym: "stimulation by symbiont of host defense response" RELATED []
synonym: "up regulation by symbiont of host defense response" RELATED []
synonym: "up-regulation by symbiont of host defense response" RELATED []
synonym: "upregulation by symbiont of host defense response" RELATED []
is_obsolete: true

[Term]
id: GO:0044417
name: translocation of molecules into host
namespace: biological_process
alt_id: GO:0051836
def: "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, PMID:18406478]
synonym: "translocation of molecules into other organism during symbiotic interaction" BROAD [GOC:dph]
synonym: "translocation of molecules into other organism involved in symbiotic interaction" BROAD []
synonym: "transport of molecules into host" EXACT []
synonym: "transport of molecules into other organism during symbiotic interaction" BROAD []
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044418
name: obsolete translocation of DNA into host
namespace: biological_process
alt_id: GO:0051837
def: "OBSOLETE. The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it was redundant with other terms.
synonym: "translocation of DNA into other organism during symbiotic interaction" BROAD [GOC:tb]
synonym: "translocation of DNA into other organism involved in symbiotic interaction" BROAD []
synonym: "transport of DNA into host" EXACT []
synonym: "transport of DNA into other organism during symbiotic interaction" BROAD []
is_obsolete: true
consider: GO:0075506
consider: GO:0075507
consider: GO:0075508

[Term]
id: GO:0044419
name: biological process involved in interspecies interaction between organisms
namespace: biological_process
def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction between organisms" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0044420
name: obsolete extracellular matrix component
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "extracellular matrix part" EXACT []
is_obsolete: true
consider: GO:0031012

[Term]
id: GO:0044421
name: obsolete extracellular region part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "extracellular structure" RELATED [NIF_Subcellular:sao9117790637]
is_obsolete: true
consider: GO:0005576

[Term]
id: GO:0044422
name: obsolete organelle part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0043226

[Term]
id: GO:0044423
name: virion component
namespace: cellular_component
alt_id: GO:0019012
def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
synonym: "complete virus particle" RELATED []
synonym: "virion" RELATED []
synonym: "virion part" EXACT []
xref: Wikipedia:Virus
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0044424
name: obsolete intracellular part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0005622

[Term]
id: GO:0044425
name: obsolete membrane part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0016020

[Term]
id: GO:0044426
name: obsolete cell wall part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0005618

[Term]
id: GO:0044427
name: obsolete chromosomal part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "chromosomal component" EXACT []
synonym: "chromosome component" EXACT []
synonym: "chromosome part" EXACT []
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0044428
name: obsolete nuclear part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "nuclear subcomponent" EXACT [NIF_Subcellular:sao1499850686]
synonym: "nucleus component" EXACT []
is_obsolete: true
consider: GO:0005634

[Term]
id: GO:0044429
name: obsolete mitochondrial part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "mitochondrial subcomponent" EXACT [NIF_Subcellular:sao666410040]
synonym: "mitochondrion component" EXACT []
is_obsolete: true
consider: GO:0005739

[Term]
id: GO:0044430
name: obsolete cytoskeletal part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "cytoskeletal element" EXACT [NIF_Subcellular:sao1635329413]
synonym: "cytoskeleton component" EXACT []
xref: NIF_Subcellular:sao1635329413
is_obsolete: true
consider: GO:0005856

[Term]
id: GO:0044431
name: obsolete Golgi apparatus part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "Golgi component" EXACT []
synonym: "Golgi subcomponent" EXACT [NIF_Subcellular:sao624292949]
is_obsolete: true
consider: GO:0005794

[Term]
id: GO:0044432
name: obsolete endoplasmic reticulum part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "ER component" EXACT []
is_obsolete: true
consider: GO:0005783

[Term]
id: GO:0044433
name: obsolete cytoplasmic vesicle part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0031410

[Term]
id: GO:0044434
name: obsolete chloroplast part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0009507

[Term]
id: GO:0044435
name: obsolete plastid part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0009536

[Term]
id: GO:0044436
name: obsolete thylakoid part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0009579

[Term]
id: GO:0044437
name: obsolete vacuolar part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "vacuole component" EXACT []
is_obsolete: true
consider: GO:0005773

[Term]
id: GO:0044438
name: obsolete microbody part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0042579

[Term]
id: GO:0044439
name: obsolete peroxisomal part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "peroxisome component" EXACT []
is_obsolete: true
consider: GO:0005777

[Term]
id: GO:0044440
name: obsolete endosomal part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered." [GOC:mah, PMID:19696797]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "endosomal subcomponent" EXACT [NIF_Subcellular:sao1683772610]
synonym: "endosome component" EXACT []
is_obsolete: true
consider: GO:0005768

[Term]
id: GO:0044441
name: obsolete ciliary part
namespace: cellular_component
alt_id: GO:0044442
def: "OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial part" EXACT []
synonym: "cilium part" EXACT []
synonym: "flagellar part" NARROW []
synonym: "flagellum component" NARROW []
synonym: "flagellum part" NARROW []
synonym: "microtubule-based flagellum part" EXACT []
is_obsolete: true
consider: GO:0005929

[Term]
id: GO:0044443
name: obsolete pilus part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "fimbrial part" EXACT []
synonym: "fimbrium component" EXACT []
synonym: "pilus component" EXACT []
is_obsolete: true
consider: GO:0009289

[Term]
id: GO:0044444
name: obsolete cytoplasmic part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "cytoplasm component" EXACT []
is_obsolete: true
consider: GO:0005737

[Term]
id: GO:0044445
name: obsolete cytosolic part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "cytosol component" EXACT []
is_obsolete: true
consider: GO:0005829

[Term]
id: GO:0044446
name: obsolete intracellular organelle part
namespace: cellular_component
def: "OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0043229

[Term]
id: GO:0044447
name: obsolete axoneme part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:cilia, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "axonemal part" EXACT []
is_obsolete: true
consider: GO:0005930

[Term]
id: GO:0044448
name: obsolete cell cortex part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0005938

[Term]
id: GO:0044449
name: obsolete contractile fiber part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "contractile fibre component" EXACT []
synonym: "muscle fiber component" BROAD []
synonym: "muscle fibre component" BROAD []
is_obsolete: true
consider: GO:0043292

[Term]
id: GO:0044450
name: obsolete microtubule organizing center part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "microtubule organizing centre component" EXACT []
synonym: "MTOC component" EXACT []
is_obsolete: true
consider: GO:0005815

[Term]
id: GO:0044451
name: obsolete nucleoplasm part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0005654

[Term]
id: GO:0044452
name: obsolete nucleolar part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "nucleolus component" EXACT []
is_obsolete: true
consider: GO:0005730

[Term]
id: GO:0044453
name: obsolete nuclear membrane part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0031965

[Term]
id: GO:0044454
name: obsolete nuclear chromosome part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0000228

[Term]
id: GO:0044455
name: obsolete mitochondrial membrane part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0031966

[Term]
id: GO:0044456
name: obsolete synapse part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "synaptic component" RELATED [NIF_Subcellular:sao1784069613]
xref: NIF_Subcellular:sao1784069613
is_obsolete: true
consider: GO:0045202

[Term]
id: GO:0044457
name: obsolete cell septum part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0030428

[Term]
id: GO:0044458
name: motile cilium assembly
namespace: biological_process
alt_id: GO:1903887
def: "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]
synonym: "motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "motile primary cilium assembly" RELATED []
synonym: "motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:0060271 ! cilium assembly

[Term]
id: GO:0044459
name: obsolete plasma membrane part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0005886

[Term]
id: GO:0044460
name: obsolete flagellum part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum part ; GO:0044461'.
synonym: "flagellum component" EXACT []
synonym: "flagellum part" EXACT []
is_obsolete: true

[Term]
id: GO:0044461
name: obsolete bacterial-type flagellum part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the bacterial-type flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by a transmembrane ion potential, typically a proton or sodium potential." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, GOC:jl, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:25251856]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "flagellin-based flagellum part" EXACT []
is_obsolete: true
consider: GO:0009288

[Term]
id: GO:0044462
name: obsolete external encapsulating structure part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0030312

[Term]
id: GO:0044463
name: obsolete cell projection part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0042995

[Term]
id: GO:0044464
name: obsolete cell part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602]
synonym: "protoplast" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0044465
name: modulation of sensory perception of pain in another organism
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism." [GOC:ed, PMID:18579526]
synonym: "modulation of sensory perception of pain in other organism" EXACT []
synonym: "regulation of sensory perception of pain in another organism" EXACT []
is_a: GO:0035821 ! modulation of process of another organism
is_a: GO:0051930 ! regulation of sensory perception of pain

[Term]
id: GO:0044466
name: obsolete glutaryl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203]
comment: This term was obsoleted because it represents a specific substrate, which is outside the scope of GO.
synonym: "glutaryl-CoA thioesterase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047617

[Term]
id: GO:0044467
name: glial cell-derived neurotrophic factor production
namespace: biological_process
def: "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons." [GOC:yaf, PMID:17505307]
subset: gocheck_do_not_annotate
synonym: "GDNF production" EXACT []
synonym: "glial cell line-derived neurotrophic factor production" RELATED []
synonym: "glial cell-derived neurotrophic factor secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0044468
name: envenomation resulting in modulation of blood coagulation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]
synonym: "envenomation resulting in modulation of blood coagulation in other organism" EXACT []
synonym: "envenomation resulting in regulation of blood coagulation in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044469
name: envenomation resulting in positive regulation of blood coagulation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]
synonym: "envenomation resulting in positive regulation of blood coagulation in other organism" EXACT []
is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in another organism
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism

[Term]
id: GO:0044470
name: envenomation resulting in negative regulation of blood coagulation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]
synonym: "envenomation resulting in negative regulation of blood coagulation in other organism" EXACT []
is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in another organism
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism

[Term]
id: GO:0044471
name: envenomation resulting in pore formation in membrane of another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]
synonym: "envenomation resulting in pore formation in membrane of other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044472
name: envenomation resulting in modulation of calcium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
synonym: "envenomation resulting in modulation of calcium channel activity in other organism" EXACT []
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism

[Term]
id: GO:0044473
name: envenomation resulting in negative regulation of calcium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
synonym: "envenomation resulting in negative regulation of calcium channel activity in other organism" EXACT []
is_a: GO:0044472 ! envenomation resulting in modulation of calcium channel activity in another organism

[Term]
id: GO:0044474
name: envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
synonym: "envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism" EXACT []
is_a: GO:0044473 ! envenomation resulting in negative regulation of calcium channel activity in another organism

[Term]
id: GO:0044475
name: envenomation resulting in negative regulation of high voltage-gated calcium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
synonym: "envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism" EXACT []
is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism

[Term]
id: GO:0044476
name: envenomation resulting in negative regulation of low voltage-gated calcium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
synonym: "envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism" EXACT []
is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism

[Term]
id: GO:0044477
name: envenomation resulting in negative regulation of platelet aggregation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in negative regulation of platelet aggregation in other organism" EXACT []
is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in another organism

[Term]
id: GO:0044478
name: envenomation resulting in positive regulation of platelet aggregation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in positive regulation of platelet aggregation in other organism" EXACT []
is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in another organism
is_a: GO:0044469 ! envenomation resulting in positive regulation of blood coagulation in another organism

[Term]
id: GO:0044479
name: envenomation resulting in modulation of mast cell degranulation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]
synonym: "envenomation resulting in modulation of mast cell degranulation in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044480
name: envenomation resulting in positive regulation of mast cell degranulation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]
synonym: "envenomation resulting in positive regulation of mast cell degranulation in other organism" EXACT []
is_a: GO:0044479 ! envenomation resulting in modulation of mast cell degranulation in another organism

[Term]
id: GO:0044481
name: obsolete envenomation resulting in proteolysis in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism." [GOC:fj, GOC:jl, PMID:15922779]
comment: This term was obsoleted because it represents a molecular function.
synonym: "envenomation resulting in proteolysis in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044482
name: envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism." [GOC:fj, GOC:jl, PMID:10441379, PMID:19485419]
synonym: "envenomation resulting in blood vessel ECM, causing hemorrhagic damage in other organism" EXACT []
synonym: "envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism" EXACT []
is_a: GO:0044358 ! envenomation resulting in hemorrhagic damage in another organism

[Term]
id: GO:0044483
name: envenomation resulting in impairment of hemostasis in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in impairment of hemostasis in other organism" EXACT []
synonym: "envenomation resulting in negative regulation of hemostasis in other organism" EXACT []
synonym: "envenomation, impairing hemostasis in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044484
name: envenomation resulting in fibrinolysis in another organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]
synonym: "envenomation resulting in fibrinolysis in other organism" EXACT []
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism

[Term]
id: GO:0044485
name: envenomation resulting in fibrinogenolysis in another organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]
synonym: "envenomation resulting in fibrinogenolysis in other organism" EXACT []
is_a: GO:0044536 ! envenomation resulting in depletion of circulating fibrinogen in another organism

[Term]
id: GO:0044486
name: modulation of transmission of nerve impulse in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the transmission of a nerve impulse in another organism." [GOC:jl]
synonym: "modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph]
synonym: "modulation of transmission of nerve impulse in other organism" EXACT []
synonym: "regulation of transmission of nerve impulse in other organism" EXACT []
is_a: GO:0035821 ! modulation of process of another organism
is_a: GO:0051969 ! regulation of transmission of nerve impulse

[Term]
id: GO:0044487
name: envenomation resulting in modulation of transmission of nerve impulse in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph]
synonym: "envenomation resulting in modulation of transmission of nerve impulse in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044488
name: modulation of voltage-gated sodium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]
synonym: "modulation of voltage-gated sodium channel activity in other organism" EXACT []
is_a: GO:0044561 ! modulation of ion channel activity in another organism

[Term]
id: GO:0044489
name: negative regulation of voltage-gated sodium channel activity in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of voltage-gated sodium channel activity in other organism" EXACT []
is_a: GO:0044362 ! negative regulation of molecular function in another organism
is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in another organism

[Term]
id: GO:0044490
name: positive regulation of voltage-gated sodium channel activity in another organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of voltage-gated sodium channel activity in other organism" EXACT []
is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in another organism
is_a: GO:0044491 ! positive regulation of molecular function in another organism

[Term]
id: GO:0044491
name: positive regulation of molecular function in another organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of molecular function in other organism" EXACT []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0044359 ! modulation of molecular function in another organism

[Term]
id: GO:0044492
name: envenomation resulting in modulation of voltage-gated sodium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]
synonym: "envenomation resulting in modulation of voltage-gated sodium channel activity in other organism" EXACT []
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism

[Term]
id: GO:0044493
name: envenomation resulting in negative regulation of voltage-gated sodium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]
synonym: "envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism" EXACT []
is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in another organism

[Term]
id: GO:0044494
name: envenomation resulting in positive regulation of voltage-gated sodium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]
synonym: "envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism" EXACT []
is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in another organism

[Term]
id: GO:0044495
name: modulation of blood pressure in another organism
namespace: biological_process
def: "A process by which one organism modulates the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "modulation of blood pressure in other organism" EXACT []
synonym: "regulation of blood pressure in other organism" EXACT []
is_a: GO:0044553 ! modulation of biological quality in another organism

[Term]
id: GO:0044496
name: negative regulation of blood pressure in another organism
namespace: biological_process
def: "A process by which one organism decreases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "negative regulation of blood pressure in other organism" EXACT []
is_a: GO:0044495 ! modulation of blood pressure in another organism
is_a: GO:0045776 ! negative regulation of blood pressure

[Term]
id: GO:0044497
name: positive regulation of blood pressure in another organism
namespace: biological_process
def: "A process by which one organism increases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "positive regulation of blood pressure in other organism" EXACT []
is_a: GO:0044495 ! modulation of blood pressure in another organism
is_a: GO:0045777 ! positive regulation of blood pressure

[Term]
id: GO:0044498
name: envenomation resulting in modulation of blood pressure in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "envenomation resulting in modulation of blood pressure in other organism" EXACT []
synonym: "envenomation resulting in regulation of blood pressure in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044499
name: envenomation resulting in positive regulation of blood pressure in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "envenomation resulting in positive regulation of blood pressure in other organism" EXACT []
is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in another organism

[Term]
id: GO:0044500
name: envenomation resulting in negative regulation of blood pressure in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "envenomation resulting in negative regulation of blood pressure in other organism" EXACT []
synonym: "hypotensive activity in other organism" EXACT []
is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in another organism

[Term]
id: GO:0044501
name: obsolete perturbation of signal transduction in another organism
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism." [GOC:fj, GOC:jl]
comment: This term was obsoleted because it is too general.
synonym: "modulation of signal transduction in another organism" EXACT []
synonym: "modulation of signal transduction in other organism" EXACT []
is_obsolete: true
consider: GO:0044509
consider: GO:0052027

[Term]
id: GO:0044503
name: modulation of G protein-coupled receptor activity in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a G protein-coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "modulation of G protein-coupled receptor activity in other organism" EXACT []
synonym: "modulation of G-protein coupled receptor activity in other organism" EXACT []
is_a: GO:0044504 ! modulation of receptor activity in another organism

[Term]
id: GO:0044504
name: modulation of receptor activity in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "modulation of receptor activity in other organism" EXACT []
is_a: GO:0044359 ! modulation of molecular function in another organism

[Term]
id: GO:0044505
name: positive regulation of G protein-coupled receptor activity in another organism
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of the activity of a G protein-coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of G protein-coupled receptor activity in other organism" EXACT []
synonym: "positive regulation of G-protein coupled receptor activity in other organism" EXACT []
is_a: GO:0044503 ! modulation of G protein-coupled receptor activity in another organism
is_a: GO:0044507 ! positive regulation of receptor activity in another organism
is_a: GO:2000273 ! positive regulation of signaling receptor activity

[Term]
id: GO:0044506
name: modulation of glucagon-like peptide receptor 1 activity in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "modulation of glucagon-like peptide receptor 1 activity in other organism" EXACT []
synonym: "regulation of glucagon-like peptide receptor activity in other organism" EXACT []
is_a: GO:0044504 ! modulation of receptor activity in another organism

[Term]
id: GO:0044507
name: positive regulation of receptor activity in another organism
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of receptor activity in other organism" EXACT []
is_a: GO:0044491 ! positive regulation of molecular function in another organism
is_a: GO:0044504 ! modulation of receptor activity in another organism

[Term]
id: GO:0044508
name: glucagon-like peptide 1 receptor activity
namespace: molecular_function
def: "Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein." [GOC:jl, PMID:12529935]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0044509
name: envenomation resulting in modulation of signal transduction in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "envenomation resulting in modulation of signal transduction in other organismm" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044510
name: envenomation resulting in positive regulation of signal transduction in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "envenomation resulting in positive regulation of signal transduction in other organism" EXACT []
is_a: GO:0044509 ! envenomation resulting in modulation of signal transduction in another organism

[Term]
id: GO:0044511
name: envenomation resulting in modulation of receptor activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "envenomation resulting in modulation of receptor activity in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044512
name: envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism" EXACT []
is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in another organism

[Term]
id: GO:0044513
name: envenomation resulting in modulation of G protein-coupled receptor activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G protein-coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "envenomation resulting in modulation of G protein-coupled receptor activity in other organism" EXACT []
synonym: "envenomation resulting in modulation of G-protein coupled receptor activity in other organism" EXACT []
is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in another organism

[Term]
id: GO:0044514
name: envenomation resulting in positive regulation of G protein-coupled receptor activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G protein-coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "envenomation resulting in positive regulation of G protein-coupled receptor activity in other organism" EXACT []
synonym: "envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism" EXACT []
is_a: GO:0044513 ! envenomation resulting in modulation of G protein-coupled receptor activity in another organism

[Term]
id: GO:0044515
name: envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism" EXACT []
is_a: GO:0044512 ! envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in another organism

[Term]
id: GO:0044516
name: obsolete positive regulation of glucagon-like peptide receptor 1 activity in another organism
namespace: biological_process
def: "OBSOLETE. A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of glucagon-like peptide receptor 1 activity in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044517
name: modulation of vasoactive intestinal polypeptide receptor activity in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl]
synonym: "modulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
synonym: "modulation of VIP receptor activity in other organism" EXACT []
synonym: "regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
is_a: GO:0044504 ! modulation of receptor activity in another organism

[Term]
id: GO:0044518
name: obsolete positive regulation of vasoactive intestinal polypeptide receptor activity in another organism
namespace: biological_process
def: "OBSOLETE. A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
synonym: "positive regulation of VIP receptor activity in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044519
name: envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
synonym: "envenomation resulting in modulation of VIP receptor activity in other organism" EXACT []
synonym: "envenomation resulting in regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
synonym: "envenomation resulting in regulation of VIP receptor activity in other organism" EXACT []
is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in another organism

[Term]
id: GO:0044520
name: envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
synonym: "envenomation resulting in positive regulation of VIP receptor activity in other organism" EXACT []
is_a: GO:0044519 ! envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in another organism

[Term]
id: GO:0044521
name: envenomation resulting in muscle damage in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]
synonym: "envenomation resulting in muscle damage in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044522
name: envenomation resulting in myocyte killing in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]
synonym: "envenomation resulting in myocyte killing causing muscle damage in other organism" EXACT []
synonym: "envenomation resulting in myocyte killing in other organism" EXACT []
is_a: GO:0044521 ! envenomation resulting in muscle damage in another organism

[Term]
id: GO:0044523
name: envenomation resulting in damage of muscle extracellular matrix in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism." [GOC:fj, GOC:jl, PMID:20398688, PMID:21150580, PMID:33460638]
synonym: "envenomation resulting in damage of muscle extracellular matrix causing muscle necrosis in other organism" EXACT []
synonym: "envenomation resulting in damage of muscle extracellular matrix in other organism" EXACT []
is_a: GO:0044521 ! envenomation resulting in muscle damage in another organism
is_a: GO:0141041 ! disruption of extracellular matrix of another organism

[Term]
id: GO:0044524
name: protein sulfhydration
namespace: biological_process
def: "The modification of a protein amino acid by the addition of sulfur." [GOC:jl, GOC:jsg, PMID:19903941, PMID:22169477, PMID:8161529]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0044525
name: peptidyl-cystine sulfhydration
namespace: biological_process
def: "The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]
subset: gocheck_obsoletion_candidate
is_a: GO:0044524 ! protein sulfhydration

[Term]
id: GO:0044526
name: obsolete formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine
namespace: biological_process
def: "OBSOLETE. The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0044527
name: obsolete formation of peptidyl-cystine persulfide by sulphur transfer from H2S
namespace: biological_process
def: "OBSOLETE. The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0044528
name: regulation of mitochondrial mRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl]
is_a: GO:0043488 ! regulation of mRNA stability

[Term]
id: GO:0044529
name: regulation of mitochondrial rRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs." [GOC:al, GOC:jl]
is_a: GO:0044357 ! regulation of rRNA stability

[Term]
id: GO:0044530
name: supraspliceosomal complex
namespace: cellular_component
def: "Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing." [GOC:ans, GOC:jl, PMID:19282290]
synonym: "supraspliceosome complex" EXACT []
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0044532
name: modulation of apoptotic process in another organism
namespace: biological_process
def: "A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism." [GOC:jl]
synonym: "modulation of apoptotic process in other organism" EXACT []
synonym: "regulation of apoptotic process in other organism" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0051709 ! regulation of killing of cells of another organism

[Term]
id: GO:0044533
name: positive regulation of apoptotic process in another organism
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism." [GOC:jl, PMID:17983639]
synonym: "positive regulation of apoptotic process in other organism" EXACT []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0044532 ! modulation of apoptotic process in another organism

[Term]
id: GO:0044534
name: obsolete envenomation resulting in modulation of apoptotic process in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism." [GOC:fj, GOC:jl, PMID:17983639]
comment: This term was obsoleted because this process is not believed to exist. Toxins cause necrosis, not apoptosis, although in some cases, damage caused by toxins may induce cells of the target organism to apoptose, but this is an indirect effect.
synonym: "envenomation resulting in modulation of apoptotic process in other organism" EXACT []
is_obsolete: true
consider: GO:0031640

[Term]
id: GO:0044535
name: very-long-chain fatty acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + O2 = a very-long-chain (2E)-enoyl-CoA + H2O2." [PMID:17458872, RHEA:78847]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very long chain fatty-acyl-CoA oxidase activity" EXACT []
synonym: "very-long-chain acyl-CoA oxidase activity" EXACT []
synonym: "VLC fatty-acyl-CoA oxidase activity" EXACT []
xref: RHEA:78847
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0044536
name: envenomation resulting in depletion of circulating fibrinogen in another organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in depletion of circulating fibrinogen in other organism" EXACT []
synonym: "envenomation resulting in negative regulation of circulating fibrinogen in other organism" EXACT []
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism
is_a: GO:0061754 ! negative regulation of circulating fibrinogen levels

[Term]
id: GO:0044537
name: regulation of circulating fibrinogen levels
namespace: biological_process
def: "Any process that modulates the quantity of fibrinogen circulating in the bloodstream." [GOC:jl]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0044538
name: host cell periphery
namespace: cellular_component
def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell." [GOC:jl, PMID:20463076]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044539
name: long-chain fatty acid import into cell
namespace: biological_process
def: "The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:jl, GOC:pm, PMID:22022213]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain fatty acid import" RELATED []
synonym: "long-chain fatty acid uptake" EXACT []
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0098657 ! import into cell
is_a: GO:0140354 ! lipid import into cell

[Term]
id: GO:0044540
name: L-cystine L-cysteine-lyase (deaminating)
namespace: molecular_function
def: "Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide." [GOC:jl, RHEA:24927]
xref: EC:4.4.1.35
xref: KEGG_REACTION:R02408
xref: RHEA:24927
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0044541
name: zymogen activation in another organism
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism." [GOC:fj, GOC:jl]
synonym: "zymogen activation in other organism" EXACT []
is_a: GO:0031638 ! zymogen activation

[Term]
id: GO:0044542
name: symbiont-mediated activation of host plasminogen
namespace: biological_process
def: "A process in which a symbiont initiates, promotes, or enhances the normal activation of plasminogen, the pathway resulting in the processing of inactive plasminogen to active plasmin in the host organism. This can facilitate the dissemination of the symbiont into host tissues. It can also be used to destroy complement, opsonins as well as antibacterial proteins like histones." [PMID:18070889, PMID:27533300, PMID:34305859]
synonym: "plasminogen activation in another organism" BROAD []
synonym: "plasminogen activation in other organism" BROAD []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0044543
name: obsolete envenomation resulting in zymogen activation in another organism
namespace: biological_process
def: "OBSOLETE. The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form." [GOC:fj, GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
synonym: "envenomation resulting in zymogen activation in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044544
name: envenomation resulting in plasminogen activation in another organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in plasminogen activation in other organism" EXACT []
is_a: GO:0044484 ! envenomation resulting in fibrinolysis in another organism

[Term]
id: GO:0044545
name: NSL complex
namespace: cellular_component
def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]
synonym: "non-specific lethal complex" EXACT []
is_a: GO:1902562 ! H4 histone acetyltransferase complex

[Term]
id: GO:0044546
name: NLRP3 inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell." [GOC:jl, PMID:21048113]
synonym: "NALP3 inflammasome complex assembly" EXACT []
synonym: "NLRP3 inflammasome activation" RELATED []
is_a: GO:0140632 ! canonical inflammasome complex assembly

[Term]
id: GO:0044547
name: DNA topoisomerase binding
namespace: molecular_function
alt_id: GO:0017033
def: "Binding to a DNA topoisomerase." [GOC:jl]
synonym: "DNA topoisomerase I binding" NARROW []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0044548
name: S100 protein binding
namespace: molecular_function
alt_id: GO:0048154
alt_id: GO:0048155
def: "Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
synonym: "S100 alpha binding" NARROW []
synonym: "S100 beta binding" NARROW []
synonym: "S100 binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0044549
name: GTP cyclohydrolase binding
namespace: molecular_function
alt_id: GO:0043106
def: "Binding to a GTP cyclohydrolase." [GOC:jl]
synonym: "GTP cyclohydrolase I binding" NARROW []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0044550
name: secondary metabolite biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
subset: goslim_prokaryote
synonym: "secondary metabolite biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0044551
name: envenomation resulting in vasodilation in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:21050868]
synonym: "envenomation resulting in modulation of vasodilation in other organism" RELATED []
synonym: "envenomation resulting in regulation of vasodilation in other organism" RELATED []
synonym: "envenomation resulting in vasodilation in other organism" EXACT []
is_a: GO:0044500 ! envenomation resulting in negative regulation of blood pressure in another organism

[Term]
id: GO:0044552
name: vasodilation in another organism
namespace: biological_process
def: "A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism." [GOC:ecd, GOC:jl, PMID:21050868]
synonym: "modulation of vasodilation in other organism" RELATED []
synonym: "regulation of vasodilation in other organism" RELATED []
synonym: "vasodilation in other organism" EXACT []
is_a: GO:0042311 ! vasodilation
is_a: GO:0044553 ! modulation of biological quality in another organism

[Term]
id: GO:0044553
name: modulation of biological quality in another organism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:jl]
synonym: "modulation of biological quality in other organism" EXACT []
synonym: "regulation of biological quality in other organism" EXACT []
is_a: GO:0035821 ! modulation of process of another organism

[Term]
id: GO:0044554
name: modulation of heart rate in another organism
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction of another organism." [GOC:jl, PMID:20923766]
synonym: "modulation of heart rate in other organism" EXACT []
synonym: "regulation of heart rate in other organism" EXACT []
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0044553 ! modulation of biological quality in another organism

[Term]
id: GO:0044555
name: negative regulation of heart rate in another organism
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency of heart contraction of another organism." [GOC:ecd, GOC:jl, PMID:20923766]
synonym: "negative regulation of heart rate in other organism" EXACT []
is_a: GO:0010459 ! negative regulation of heart rate
is_a: GO:0044554 ! modulation of heart rate in another organism

[Term]
id: GO:0044556
name: envenomation resulting in negative regulation of heart rate in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:20923766]
synonym: "envenomation resulting in negative regulation of heart rate of other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044557
name: relaxation of smooth muscle
namespace: biological_process
def: "A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:jl]
synonym: "smooth muscle relaxation" EXACT []
is_a: GO:0090075 ! relaxation of muscle

[Term]
id: GO:0044558
name: uterine smooth muscle relaxation
namespace: biological_process
def: "A process in which the extent of smooth muscle contraction is reduced in the uterus." [GOC:jl]
synonym: "smooth muscle relaxation of the uterus" EXACT []
is_a: GO:0044557 ! relaxation of smooth muscle

[Term]
id: GO:0044559
name: envenomation resulting in modulation of voltage-gated potassium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in modulation of voltage-gated potassium channel activity in other organism" EXACT []
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism

[Term]
id: GO:0044560
name: envenomation resulting in modulation of ion channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in modulation of ion channel activity in other organism" EXACT []
synonym: "envenomation resulting in regulation of ion channel activity in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044561
name: modulation of ion channel activity in another organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism." [GOC:jl]
synonym: "modulation of ion channel activity in other organism" EXACT []
synonym: "regulation of ion channel activity in other organism" EXACT []
is_a: GO:0044359 ! modulation of molecular function in another organism

[Term]
id: GO:0044562
name: envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism" EXACT []
is_a: GO:0044559 ! envenomation resulting in modulation of voltage-gated potassium channel activity in another organism

[Term]
id: GO:0044563
name: envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism" EXACT []
synonym: "voltage-dependence of activation shift (to the left)" EXACT []
is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism

[Term]
id: GO:0044564
name: envenomation resulting in occlusion of the pore of voltage-gated potassium channel in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism" EXACT []
is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism

[Term]
id: GO:0044565
name: dendritic cell proliferation
namespace: biological_process
def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816]
is_a: GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0044566
name: chondrocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0044567
name: primary cell wall cellulose synthase complex
namespace: cellular_component
def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein." [GOC:mengo_curators, GOC:tt, PMID:17878302, PMID:21307367]
synonym: "primary cell wall CESA complex" EXACT []
synonym: "primary cell-wall cellulose synthase complex" EXACT []
is_a: GO:0010330 ! cellulose synthase complex

[Term]
id: GO:0044568
name: secondary cell wall cellulose synthase complex
namespace: cellular_component
def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4." [GOC:mengo_curators, GOC:tt, PMID:21307367]
synonym: "secondary cell wall CESA complex" EXACT []
synonym: "secondary cell-wall cellulose synthase complex" EXACT []
is_a: GO:0010330 ! cellulose synthase complex

[Term]
id: GO:0044569
name: [Ni-Fe] hydrogenase complex
namespace: cellular_component
def: "A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer." [GOC:mengo_curators, GOC:tt, PMID:8936309]
synonym: "Ni-Fe hydrogenase complex" EXACT []
synonym: "nickel-iron hydrogenase complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0044570
name: starch utilization system complex
namespace: cellular_component
def: "A bacterial cell envelope-associated multiprotein system, which binds and degrades starch." [GOC:mengo_curators, GOC:tt, PMID:19553672]
synonym: "Sus complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0044571
name: [2Fe-2S] cluster assembly
namespace: biological_process
def: "The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]
synonym: "2Fe-2S cluster assembly" EXACT []
synonym: "[2Fe-2S] cluster biosynthetic process" RELATED []
is_a: GO:0016226 ! iron-sulfur cluster assembly

[Term]
id: GO:0044572
name: [4Fe-4S] cluster assembly
namespace: biological_process
def: "The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]
synonym: "4Fe-4S cluster assembly" EXACT []
synonym: "[4Fe-4S] cluster biosynthetic process" RELATED []
is_a: GO:0016226 ! iron-sulfur cluster assembly

[Term]
id: GO:0044573
name: nitrogenase P cluster assembly
namespace: biological_process
def: "The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide." [PMID:17563349]
synonym: "nitrogenase P cluster biosynthesis" EXACT []
synonym: "nitrogenase P cluster maturation" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly

[Term]
id: GO:0044574
name: starch utilization system complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan." [GOC:mengo_curators, GOC:tt, PMID:19553672, PMID:21219452]
synonym: "assembly of starch utilization system complex" EXACT []
synonym: "SUS complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0044575
name: cellulosome assembly
namespace: biological_process
def: "The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall." [GOC:mengo_curators, GOC:tt, PMID:20373916]
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:0044576
name: obsolete pentose catabolic process to ethanol
namespace: biological_process
def: "OBSOLETE. The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "pentose catabolism to ethanol" EXACT []
is_obsolete: true

[Term]
id: GO:0044577
name: D-xylose catabolic process to ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, into ethanol." [GOC:mengo_curators, GOC:tt, PMID:26927067]
synonym: "D-xylose fermentation" EXACT []
synonym: "xylose catabolism to ethanol" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0006113 ! fermentation
is_a: GO:0042843 ! D-xylose catabolic process

[Term]
id: GO:0044578
name: butyryl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA." [GOC:jl]
synonym: "butyryl-CoA biosynthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process

[Term]
id: GO:0044579
name: butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA." [GOC:mengo_curators, GOC:tt, PMID:19539744]
synonym: "butyryl-CoA biosynthesis from acetyl-CoA" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0044578 ! butyryl-CoA biosynthetic process

[Term]
id: GO:0044580
name: butyryl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA." [GOC:jl]
synonym: "butyryl-CoA catabolism" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process

[Term]
id: GO:0044581
name: butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate." [GOC:mengo_curators, GOC:tt, PMID:19539744]
synonym: "butyryl-CoA catabolism to butyrate" EXACT []
is_a: GO:0044580 ! butyryl-CoA catabolic process
is_a: GO:0046358 ! butyrate biosynthetic process

[Term]
id: GO:0044582
name: butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol." [GOC:mengo_curators, GOC:tt, PMID:19539744]
synonym: "butyryl-CoA catabolism to butanol" EXACT []
is_a: GO:0044580 ! butyryl-CoA catabolic process
is_a: GO:0071271 ! 1-butanol biosynthetic process

[Term]
id: GO:0044583
name: cellotriose binding
namespace: molecular_function
def: "Binding to cellotriose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0048031 ! trisaccharide binding

[Term]
id: GO:0044584
name: cellodextrin binding
namespace: molecular_function
def: "Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers." [GOC:mengo_curators, GOC:tt, PMID:18952792]
is_a: GO:0030247 ! polysaccharide binding
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0044585
name: cellobiose binding
namespace: molecular_function
def: "Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0048030 ! disaccharide binding

[Term]
id: GO:0044586
name: cellotetraose binding
namespace: molecular_function
def: "Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0044587
name: cellopentaose binding
namespace: molecular_function
def: "Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0044588
name: laminaribiose binding
namespace: molecular_function
def: "Binding to laminaribiose, a disaccharide." [GOC:mengo_curators, GOC:tt]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0044589
name: pectin binding
namespace: molecular_function
def: "Binding to pectin." [GOC:mengo_curators, GOC:tt]
is_a: GO:0048028 ! galacturonan binding

[Term]
id: GO:0044590
name: iron-sulfur-molybdenum cofactor binding
namespace: molecular_function
def: "Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691]
synonym: "FeMo co binding" EXACT []
synonym: "FeMoco binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0044591
name: response to amylopectin
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus." [GOC:mengo_curators, GOC:tt]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0044592
name: response to pullulan
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus." [GOC:mengo_curators, GOC:tt]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0044593
name: iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691]
synonym: "FeMoco assembly" EXACT []
synonym: "FeMoco biosynthetic process" EXACT []
synonym: "iron molybdenum cofactor assembly" EXACT []
synonym: "iron molybdenum cofactor biosynthesis" EXACT []
synonym: "iron molybdenum cofactor biosynthetic process" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly

[Term]
id: GO:0044594
name: 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+." [PMID:17074428]
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044595
name: obsolete decaprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate." [PMID:10777520]
comment: This term was obsoleted because it represents a specific substrate of 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity ; GO:0010420
is_obsolete: true
replaced_by: GO:0010420

[Term]
id: GO:0044596
name: obsolete 3-demethylubiquinol-10 3-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10." [PMID:10777520]
comment: This term was obsoleted because it represents a specific substrate of 3-demethylubiquinol-n 3-O-methyltransferase activity ; GO:0061542.
is_obsolete: true
replaced_by: GO:0061542

[Term]
id: GO:0044597
name: daunorubicin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer." [PMID:20837989]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0044598
name: doxorubicin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy." [PMID:10200167]
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0044599
name: AP-5 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo." [PMID:22022230]
synonym: "adaptor protein-5 adaptor complex" EXACT []
is_a: GO:0030119 ! AP-type membrane coat adaptor complex

[Term]
id: GO:0044600
name: protein guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins." [GOC:sp, PMID:20651120]
xref: Reactome:R-HSA-9765952 "nsp12 guanylates nsp7"
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0044601
name: protein denucleotidylation
namespace: biological_process
def: "The removal of a nucleotide from a protein amino acid." [GOC:sp, PMID:21734656]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0044602
name: protein deadenylylation
namespace: biological_process
def: "The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid." [GOC:sp, PMID:21734656]
subset: gocheck_obsoletion_candidate
synonym: "protein deAMPylation" EXACT [PMID:21734656]
is_a: GO:0044601 ! protein denucleotidylation

[Term]
id: GO:0044603
name: protein adenylylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins." [PMID:21734656]
synonym: "protein deAMPylase activity" EXACT [PMID:21734656]
synonym: "protein deAMPylation activity" EXACT [PMID:21734656]
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0044604
name: ABC-type phytochelatin transporter activity
namespace: molecular_function
alt_id: GO:0071991
alt_id: GO:0071992
def: "Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, PMID:1396551]
synonym: "ABC-type phytochelatin transmembrane transporter activity" EXACT []
synonym: "ATP-dependent phytochelatin transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled phytochelatin transmembrane transporter activity" RELATED []
synonym: "cadystin transmembrane transporter activity" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "cadystin transmembrane transporter ATPase activity" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "cadystin transporter activity" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "phytochelatin transmembrane transporter activity" RELATED []
synonym: "phytochelatin transmembrane transporter ATPase activity" RELATED []
synonym: "phytochelatin transporter activity" RELATED []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0044605
name: phosphocholine transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate." [GOC:sp, PMID:21822290]
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0044606
name: phosphocholine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate." [GOC:sp, PMID:22158903]
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0044607
name: obsolete disruption by symbiont of host endothelial cells
namespace: biological_process
def: "OBSOLETE. Any process in which an organism has a negative effect on the functioning of the host's endothelial cells." [GOC:jl]
comment: This term was obsoleted because the cell type should be captured as an annotation extension.
is_obsolete: true

[Term]
id: GO:0044608
name: obsolete peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine
namespace: biological_process
def: "OBSOLETE. The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester." [RESID:AA0507]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-threonine esterification" EXACT []
is_obsolete: true

[Term]
id: GO:0044609
name: DBIRD complex
namespace: cellular_component
def: "A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD." [GOC:sp, PMID:22446626]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0044610
name: FMN transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other." [GOC:ans, PMID:22185573]
synonym: "flavine mononucleotide transmembrane transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0044611
name: nuclear pore inner ring
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "Nup170 complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0044612
name: nuclear pore linkers
namespace: cellular_component
def: "A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "Nic96 complex" RELATED []
synonym: "Nup82 complex" RELATED []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0044613
name: nuclear pore central transport channel
namespace: cellular_component
def: "The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "karyopherin docking complex" RELATED []
synonym: "nuclear pore central channel" EXACT []
synonym: "nuclear pore central plug" EXACT []
synonym: "nuclear pore transport channel" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0044614
name: nuclear pore cytoplasmic filaments
namespace: cellular_component
def: "Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "cytoplasmic fibers of the NPC" EXACT [PMID:7775481, PMID:8978815, PMID:9456312]
synonym: "cytoplasmic fibers of the nuclear pore complex" EXACT [PMID:7775481, PMID:8978815, PMID:9456312]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0044615
name: nuclear pore nuclear basket
namespace: cellular_component
def: "A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0044616
name: modulation of relaxation of muscle in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the relaxation of muscle in a second organism." [GOC:jl]
synonym: "modulation of relaxation of muscle in other organism" EXACT []
synonym: "regulation of relaxation of muscle in other organism" EXACT []
is_a: GO:0035821 ! modulation of process of another organism
is_a: GO:1901077 ! regulation of relaxation of muscle

[Term]
id: GO:0044617
name: modulation of relaxation of smooth muscle in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the relaxation of smooth muscle in a second organism." [GOC:jl]
synonym: "modulation of relaxation of smooth muscle in other organism" EXACT []
synonym: "regulation of relaxation of smooth muscle in other organism" EXACT []
is_a: GO:0044616 ! modulation of relaxation of muscle in another organism
is_a: GO:1901080 ! regulation of relaxation of smooth muscle

[Term]
id: GO:0044618
name: modulation of relaxation of uterine smooth muscle in another organism
namespace: biological_process
def: "The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism." [GOC:jl]
synonym: "modulation of relaxation of uterine smooth muscle in other organism" EXACT []
synonym: "regulation of relaxation of uterine smooth muscle in other organism" EXACT []
is_a: GO:0044617 ! modulation of relaxation of smooth muscle in another organism
is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation

[Term]
id: GO:0044619
name: positive regulation of relaxation of uterine smooth muscle in another organism
namespace: biological_process
def: "The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism." [GOC:jl]
synonym: "positive regulation of relaxation of uterine smooth muscle in other organism" EXACT []
is_a: GO:0044618 ! modulation of relaxation of uterine smooth muscle in another organism
is_a: GO:1900721 ! positive regulation of uterine smooth muscle relaxation

[Term]
id: GO:0044620
name: ACP phosphopantetheine attachment site binding
namespace: molecular_function
def: "Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)." [GOC:jl, GOC:vw]
is_a: GO:0051192 ! prosthetic group binding

[Term]
id: GO:0044621
name: obsolete modulation of cell migration in another organism
namespace: biological_process
alt_id: GO:0044624
def: "OBSOLETE. The process in which an organism effects a change in the process of cell migration in a second organism." [GOC:jl]
comment: This term was obsoleted because it is too general.
synonym: "envenomation resulting in modulation of cell migration in another organism" NARROW []
synonym: "envenomation resulting in modulation of cell migration in other organism" NARROW []
synonym: "envenomation resulting in regulation of cell migration in other organism" NARROW []
synonym: "modulation of cell migration in other organism" EXACT []
synonym: "regulation of cell migration in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044622
name: obsolete negative regulation of cell migration in another organism
namespace: biological_process
alt_id: GO:0044625
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism." [GOC:jl]
comment: This term was obsoleted because it is too general.
synonym: "envenomation resulting in negative regulation of cell migration in another organism" NARROW []
synonym: "envenomation resulting in negative regulation of cell migration in other organism" NARROW []
synonym: "negative regulation of cell migration in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044623
name: obsolete positive regulation of cell migration in another organism
namespace: biological_process
alt_id: GO:0044626
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cell migration in a second organism." [GOC:jl]
comment: This term was obsoleted because it is too general.
synonym: "envenomation resulting in positive regulation of cell migration in another organism" NARROW []
synonym: "envenomation resulting in positive regulation of cell migration in other organism" NARROW []
synonym: "positive regulation of cell migration in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044627
name: obsolete modulation of complement activation, classical pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "modulation of complement activation, classical pathway in other organism" EXACT []
synonym: "regulation of complement activation, classical pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044628
name: obsolete positive regulation of complement activation, classical pathway in another organism
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040]
comment: This term has been obsoleted because this process does not exist.
synonym: "positive regulation of complement activation, classical pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044629
name: obsolete negative regulation of complement activation, classical pathway in another organism
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "negative regulation of complement activation, classical pathway in other organism" EXACT []
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0044630
name: obsolete modulation of complement activation, lectin pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "modulation of complement activation, lectin pathway in other organism" EXACT []
synonym: "regulation of complement activation, lectin pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044631
name: obsolete positive regulation of complement activation, lectin pathway in another organism
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because this process does not exist.
synonym: "positive regulation of complement activation, lectin pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044632
name: obsolete negative regulation of complement activation, lectin pathway in another organism
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "negative regulation of complement activation, lectin pathway in other organism" EXACT []
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0044633
name: obsolete modulation of complement activation, alternative pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "modulation of complement activation, alternative pathway in other organism" EXACT []
synonym: "regulation of complement activation, alternative pathway in other organism" RELATED []
is_obsolete: true

[Term]
id: GO:0044634
name: obsolete negative regulation of complement activation, alternative pathway in another organism
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "negative regulation of complement activation, alternative pathway in other organism" EXACT []
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0044635
name: obsolete positive regulation of complement activation, alternative pathway in another organism
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]
comment: This term was obsoleted because this process does not exist.
synonym: "positive regulation of complement activation, alternative pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044636
name: obsolete envenomation resulting in modulation of complement activation, classical pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "envenomation resulting in modulation of complement activation, classical pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044637
name: obsolete envenomation resulting in negative regulation of complement activation, classical pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "envenomation resulting in negative regulation of complement activation, classical pathway in other organism" EXACT []
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0044638
name: obsolete envenomation resulting in positive regulation of complement activation, classical pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because this process does not exist.
synonym: "envenomation resulting in positive regulation of complement activation, classical pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044639
name: obsolete envenomation resulting in modulation of complement activation, lectin pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "envenomation resulting in modulation of complement activation, lectin pathway in other organism" EXACT []
synonym: "envenomation resulting in regulation of complement activation, lectin pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044640
name: obsolete envenomation resulting in negative regulation of complement activation, lectin pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "envenomation resulting in negative regulation of complement activation, lectin pathway in other organism" EXACT []
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0044641
name: obsolete envenomation resulting in positive regulation of complement activation, lectin pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because this process does not exist.
synonym: "envenomation resulting in positive regulation of complement activation, lectin pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044642
name: obsolete envenomation resulting in modulation of complement activation, alternative pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "envenomation resulting in modulation of complement activation, alternative pathway in other organism" EXACT []
synonym: "envenomation resulting in regulation of complement activation, alternative pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044643
name: obsolete envenomation resulting in positive regulation of complement activation, alternative pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because this pathway does not exist.
synonym: "envenomation resulting in positive regulation of complement activation, alternative pathway in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044644
name: obsolete envenomation resulting in negative regulation of complement activation, alternative pathway in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "envenomation resulting in negative regulation of complement activation, alternative pathway in other organism" EXACT []
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0044645
name: obsolete modulation of complement activation in another organism
namespace: biological_process
def: "OBSOLETE. A process that modulates the frequency, rate or extent of complement activation in a different organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too general ; consider symbiont-mediated suppression of host complement activation ; GO:0042784.
synonym: "modulation of complement activation in other organism" EXACT []
synonym: "regulation of complement activation in other organism" EXACT []
is_obsolete: true
consider: GO:0042784

[Term]
id: GO:0044646
name: obsolete envenomation resulting in modulation of complement activation in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
comment: This term was obsoleted because it is too specific.
synonym: "envenomation resulting in modulation of complement activation in other organism" EXACT []
synonym: "envenomation resulting in regulation of complement activation in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044647
name: host-symbiont bicellular tight junction
namespace: cellular_component
def: "An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane." [GOC:jl, PMID:21803641]
synonym: "host-parasite tight junction" EXACT []
synonym: "host-pathogen tight junction" EXACT []
is_a: GO:0005923 ! bicellular tight junction

[Term]
id: GO:0044648
name: obsolete histone H3-K4 dimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone." [GOC:jl, PMID:21875999]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0044650
name: adhesion of symbiont to host cell
namespace: biological_process
def: "The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl]
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0044651
name: adhesion of symbiont to host epithelial cell
namespace: biological_process
def: "The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176]
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0044652
name: adhesion of symbiont to host endothelial cell
namespace: biological_process
def: "The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176]
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0044653
name: obsolete dextrin alpha-glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dextrin + H2O = alpha-D-glucose." [PMID:18556189]
comment: This term was obsoleted because it represents a specific substrate of alpha-1,4-glucosidase activity ; GO:0004558.
is_obsolete: true
replaced_by: GO:0004558

[Term]
id: GO:0044654
name: obsolete starch alpha-glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: starch + H2O = alpha-D-glucose." [PMID:18556189]
comment: This term was obsoleted because it represents a specific substrate of alpha-1,4-glucosidase activity ; GO:0004558.
is_obsolete: true
replaced_by: GO:0004558

[Term]
id: GO:0044655
name: phagosome reneutralization
namespace: biological_process
def: "Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation." [GOC:rjd, PMID:22008230]
synonym: "phagosomal reneutralization" EXACT []
synonym: "phagosome pH elevation" EXACT []
is_a: GO:0051454 ! intracellular pH elevation
relationship: part_of GO:0090382 ! phagosome maturation

[Term]
id: GO:0044656
name: regulation of post-lysosomal vacuole size
namespace: biological_process
def: "Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:rjd, PMID:22008230]
synonym: "regulation of post-lysosome size" EXACT [GOC:dph]
synonym: "regulation of postlysosomal vacuole size" EXACT []
synonym: "regulation of postlysosome vacuole size" EXACT []
is_a: GO:0097494 ! regulation of vesicle size

[Term]
id: GO:0044657
name: obsolete pore formation in membrane of other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction." [GOC:jl]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0044658
name: symbiont-mediated pore formation in host plasma membrane
namespace: biological_process
def: "The disruption of host plasma membrane integrity by formation of a pore, resulting in deregulated ion homeostasis, and cellular dysfunction that can result in cell death." [GOC:jl, PMID:7510043]
synonym: "pore formation in host plasma membrane" EXACT []
synonym: "pore formation in membrane of host by symbiont" BROAD []
is_a: GO:0051673 ! disruption of plasma membrane integrity in another organism
is_a: GO:0141171 ! symbiont-mediated perturbation of host membrane

[Term]
id: GO:0044659
name: viral release from host cell by cytolysis
namespace: biological_process
alt_id: GO:0019077
alt_id: GO:0046756
def: "The dissemination of mature viral particles from a host cell by the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, PMID:26728778]
synonym: "cytolysis by virus of host cell" RELATED []
synonym: "lytic viral life cycle" RELATED []
synonym: "lytic viral release" EXACT []
synonym: "viral exit from host cell by cytolysis" EXACT []
synonym: "viral release by cell lysis" EXACT []
synonym: "viral release by host cell lysis" EXACT []
xref: VZ:1077 "Cell lysis"
is_a: GO:0001897 ! symbiont-mediated cytolysis of host cell
is_a: GO:0019076 ! viral release from host cell
is_a: GO:0051673 ! disruption of plasma membrane integrity in another organism

[Term]
id: GO:0044660
name: viral release via pore formation in host cell membrane
namespace: biological_process
def: "The dissemination of mature viral particles from a host cell via the formation by the virus of pores in its host cell membrane." [GOC:jl]
synonym: "cytolysis by virus via pore formation in host cell membrane" RELATED []
synonym: "viral exit by cytolysis via pore formation in host cell membrane" EXACT []
synonym: "viral release by cytolysis via pore formation in host cell membrane" EXACT []
is_a: GO:0044659 ! viral release from host cell by cytolysis

[Term]
id: GO:0044663
name: establishment or maintenance of cell type involved in phenotypic switching
namespace: biological_process
def: "A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl]
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0036166 ! phenotypic switching

[Term]
id: GO:0044664
name: obsolete reversion of cell type to default state involved in phenotypic switching
namespace: biological_process
def: "OBSOLETE. The cellular process of the reversion of cells to their original cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl]
comment: This term was made obsolete because it is ambiguous.
is_obsolete: true

[Term]
id: GO:0044665
name: MLL1/2 complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]
synonym: "Trx-containing complex" EXACT []
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0044666
name: MLL3/4 complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]
synonym: "Trr/COMPASS-like complex" EXACT []
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0044667
name: (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)." [GOC:crds]
synonym: "(R)-carnitine:gamma-butyrobetaine antiporter activity" EXACT []
synonym: "L-carnitine:4-(trimethylammonio)butanoate antiporter activity" EXACT []
synonym: "L-carnitine:gamma-butyrobetaine antiporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-100
xref: RHEA:29427
is_a: GO:0015297 ! antiporter activity
is_a: GO:1901235 ! (R)-carnitine transmembrane transporter activity
is_a: GO:1901236 ! 4-(trimethylammonio)butanoate transmembrane transporter activity

[Term]
id: GO:0044668
name: sodium:malonate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in)." [GOC:crds]
xref: RHEA:33135
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity
is_a: GO:1901239 ! malonate(1-) transmembrane transporter activity

[Term]
id: GO:0044669
name: sodium:galactoside symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)." [GOC:crds]
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0044671
name: sorocarp spore cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass)." [GOC:jl, GOC:rjd]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048837 ! sorocarp sorus development

[Term]
id: GO:0044672
name: acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex
namespace: cellular_component
def: "A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis." [GOC:mengo_curators, PMID:11607176, PMID:7693685, PMID:8955306]
synonym: "carbon monoxide dehydrogenase" BROAD []
synonym: "carbon-monoxide:(acceptor) oxidoreductase complex" BROAD []
synonym: "CO dehydrogenase complex" BROAD []
synonym: "CO dehydrogenase/acetyl-CoA synthase complex" EXACT []
synonym: "CODH" BROAD []
synonym: "CODH/ACS complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0044673
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex
namespace: cellular_component
def: "A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420." [GOC:mengo_curators, PMID:14593448]
synonym: "FO-synthase complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0044674
name: methyl coenzyme M reductase complex
namespace: cellular_component
def: "A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis." [GOC:mengo_curators, PMID:9367957]
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0044675
name: formyl-methanofuran dehydrogenase (tungsten enzyme) complex
namespace: cellular_component
def: "A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:8125106, PMID:8575452]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0044676
name: formyl-methanofuran dehydrogenase (molybdenum enzyme) complex
namespace: cellular_component
def: "A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:1915887, PMID:8954165]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0044677
name: methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex
namespace: cellular_component
def: "A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis." [GOC:mengo_curators, PMID:8477726]
synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex" EXACT []
synonym: "coenzyme M methyltransferase complex" BROAD []
synonym: "methyl-H4MPT" BROAD []
synonym: "N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0044678
name: CoB-CoM heterodisulfide reductase complex
namespace: cellular_component
def: "A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine." [GOC:mengo_curators, PMID:8119281, PMID:8174566, PMID:9063468]
synonym: "coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex" EXACT []
synonym: "hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex" EXACT []
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0044679
name: methanophenazine reducing hydrogenase complex
namespace: cellular_component
def: "A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides." [GOC:mengo_curators, PMID:9555882]
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0044680
name: methylthiol:coenzyme M methyltransferase complex
namespace: cellular_component
def: "A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis." [GOC:mengo_curators, PMID:11073950, PMID:9371433]
synonym: "methylthiol coenzyme M methyl transferase complex" EXACT []
synonym: "methylthiol:coenzyme M methyl transferase complex" EXACT []
synonym: "methylthiol:CoM methyltransferase complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0044681
name: sulfopyruvate decarboxylase complex
namespace: cellular_component
def: "A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis." [GOC:mengo_curators, PMID:10940029]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0044682
name: GTP cyclohydrolase IV activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+." [GOC:mengo_curators, PMID:17497938, RHEA:25860]
synonym: "archaeal-specific GTP cyclohydrolase activity" EXACT []
synonym: "Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity" EXACT []
synonym: "MptA activity" NARROW []
xref: EC:3.5.4.39
xref: RHEA:25860
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0044683
name: methylthiol:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM." [MetaCyc:RXN-8125, PMID:9371433]
comment: This reaction is achieved by the catalysis of two successive steps carried out by the same enzyme - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC:2.1.1.90, methanol-corrinoid protein Co-methyltransferase, and EC:2.1.1.246, methylated methanol-specific corrinoid protein:coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.
synonym: "methylthiol:coenzyme M methyl transferase activity" EXACT []
xref: EC:2.1.1.251
xref: MetaCyc:RXN-8125
xref: RHEA:32667
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0044684
name: dihydromethanopterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP." [GOC:mengo_curators, PMID:15028691]
xref: EC:1.5.99.15
xref: RHEA:42804
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044685
name: obsolete tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O." [GOC:mengo_curators, PMID:12902326]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0044686
name: cysteate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-serine + sulfite + H+ = L-cysteate + phosphate." [PMID:19761441, RHEA:26486]
xref: EC:2.5.1.76
xref: MetaCyc:RXN-11108
xref: RHEA:26486
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0044687
name: geranylfarnesyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate." [PMID:20097171, RHEA:25694]
synonym: "FGPP synthase activity" EXACT [EC:2.5.1.81]
xref: EC:2.5.1.81
xref: MetaCyc:RXN-8813
xref: RHEA:25694
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0044688
name: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+." [GOC:mengo_curators, PMID:19746965]
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0044689
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H+ + L-methionine + NH4+." [PMID:14593448, RHEA:55204]
synonym: "FO synthase" EXACT []
xref: EC:4.3.1.32
xref: MetaCyc:RXN-19230
xref: RHEA:55204
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0044691
name: tooth eruption
namespace: biological_process
def: "The tooth development process in which the teeth enter the mouth and become visible." [Wikipedia:Tooth_eruption]
xref: Wikipedia:Tooth_eruption
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0042476 ! odontogenesis

[Term]
id: GO:0044692
name: exoribonuclease activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an exoribonuclease." [GOC:rb, PMID:22570495]
is_a: GO:0170054 ! ribonuclease activator activity

[Term]
id: GO:0044693
name: trehalose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)." [PMID:11136464]
synonym: "trehalose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! carbohydrate:proton symporter activity
is_a: GO:0015574 ! trehalose transmembrane transporter activity

[Term]
id: GO:0044694
name: symbiont genome entry into host cell via pore formation in plasma membrane
namespace: biological_process
def: "Entry of a symbiont's genome into a host cell by a pore formed by the symbiont in the host cell. Examples of this process include injection by a non-enveloped virus of the viral genome into the host cytoplasm, usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail." [GOC:jl, VZ:979]
comment: This mechanism is used by animal viruses such as poliovirus. Various tailed bacteriophages also carry specialized proteins which open a pore or a channel in the host membrane(s) to allow genome delivery into host cytoplasm.
synonym: "membrane puncture-mediated penetration of viral genome into host cell" RELATED [UniProtKB-KW:KW-1172]
synonym: "pore-mediated entry of viral genome into host cell" NARROW []
synonym: "pore-mediated penetration of viral genome into host cell" RELATED []
synonym: "viral entry via genome injection" RELATED []
synonym: "viral genome delivery via icosahedral vertex" NARROW []
synonym: "viral genome translocation" EXACT []
synonym: "viral pore-forming protein" NARROW [GOC:bf]
xref: VZ:979 "Pore-mediated penetration of viral genome into host cell"
is_a: GO:0141171 ! symbiont-mediated perturbation of host membrane
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0044695
name: Dsc E3 ubiquitin ligase complex
namespace: cellular_component
def: "An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism." [GOC:mah, GOC:vw, PMID:21504829]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0044696
name: killing by virus of host cell by post-segregational killing
namespace: biological_process
def: "The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes." [GOC:bf, GOC:jl, PMID:11222604, Wikipedia:Toxin-antitoxin_system]
comment: Note that this process occurs after the cell division partitioning event.
synonym: "killing by virus of host cell by PSK" EXACT []
synonym: "killing by virus of host cell by toxin-antitoxin system" EXACT []
is_a: GO:0001907 ! symbiont-mediated killing of host cell

[Term]
id: GO:0044697
name: HICS complex
namespace: cellular_component
def: "A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins." [PMID:22623719]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0044698
name: obsolete morphogenesis of symbiont in host cell
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont undergoes a change in shape or form, within the host's cell." [GOC:jl]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0044701
name: obsolete response to stimulus by single organism
namespace: biological_process
def: "OBSOLETE. A response to a stimulus that involves only one organism." [GOC:jl]
comment: This term was made obsolete because we decided that all responses are single-organism.
synonym: "response to stimulus by single organism" EXACT []
is_obsolete: true

[Term]
id: GO:0044703
name: multi-organism reproductive process
namespace: biological_process
def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl]
subset: goslim_drosophila
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0044706
name: multi-multicellular organism process
namespace: biological_process
def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0044715
name: 8-oxo-dGDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate." [GOC:pde, PMID:22556419, RHEA:32063]
xref: Reactome:R-HSA-2395876 "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP"
xref: Reactome:R-HSA-2395879 "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP"
xref: RHEA:32063
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0044716
name: 8-oxo-GDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate." [GOC:pde, PMID:22556419, RHEA:62356]
xref: Reactome:R-HSA-2395873 "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP"
xref: RHEA:62356
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0044717
name: 8-hydroxy-dADP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate." [GOC:pde, PMID:22556419]
xref: Reactome:R-HSA-2395965 "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP"
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0044718
name: siderophore transmembrane transport
namespace: biological_process
def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore." [GOC:jl]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "siderophore membrane transport" EXACT []
is_a: GO:0015891 ! siderophore transport
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0044719
name: regulation of imaginal disc-derived wing size
namespace: biological_process
def: "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
is_a: GO:0090066 ! regulation of anatomical structure size
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0044720
name: negative regulation of imaginal disc-derived wing size
namespace: biological_process
def: "Any process that reduces the size of an imaginal disc-derived wing." [PMID:21393605]
is_a: GO:0044719 ! regulation of imaginal disc-derived wing size

[Term]
id: GO:0044721
name: protein import into peroxisome matrix, substrate release
namespace: biological_process
def: "The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane." [PMID:21976670]
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0044722
name: renal phosphate excretion
namespace: biological_process
def: "The elimination of phosphate ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:jl, PMID:25287933]
synonym: "renal phosphate ion excretion" EXACT []
is_a: GO:0097254 ! renal tubular secretion

[Term]
id: GO:0044725
name: epigenetic programming in the zygotic pronuclei
namespace: biological_process
def: "The global programming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process." [GOC:sp, PMID:22868271]
synonym: "chromatin reprogramming in the zygote" EXACT []
is_a: GO:0043045 ! epigenetic programming of gene expression

[Term]
id: GO:0044726
name: epigenetic programing of female pronucleus
namespace: biological_process
def: "The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1." [GOC:sp, PMID:22868271]
synonym: "maintenance of DNA methylation at imprinted genes" RELATED []
synonym: "protection of DNA demethylation of female pronucleus" NARROW []
synonym: "protection of DNA methylation in female pronucleus" NARROW []
is_a: GO:0044725 ! epigenetic programming in the zygotic pronuclei

[Term]
id: GO:0044727
name: epigenetic programing of male pronucleus
namespace: biological_process
def: "The global programming of epigenetic modifications in the male pronucleus of the newly fertilized zygote. The most major change in the paternal genome is DNA demethylation, which takes place before the first cell division." [GOC:sp, PMID:22868271]
synonym: "DNA demethylation of male pronucleus" NARROW []
synonym: "epigenetic reprograming of male pronucleus" EXACT []
synonym: "epigenetic reprograming of paternal genome in zygote" EXACT []
is_a: GO:0044725 ! epigenetic programming in the zygotic pronuclei

[Term]
id: GO:0044728
name: obsolete DNA methylation or demethylation
namespace: biological_process
def: "OBSOLETE. The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "changes in DNA methylation" RELATED []
is_obsolete: true

[Term]
id: GO:0044729
name: hemi-methylated DNA-binding
namespace: molecular_function
def: "Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, GOC:sp, PMID:18772889]
synonym: "double-stranded hemi-methylated DNA binding" EXACT []
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0044730
name: bone sialoprotein binding
namespace: molecular_function
def: "Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin." [PMID:10642520]
synonym: "bone sialoprotein II binding" EXACT []
xref: InterPro:IPR008412
is_a: GO:0005515 ! protein binding
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0044731
name: Ost-alpha/Ost-beta complex
namespace: cellular_component
def: "A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity." [PMID:17650074, PMID:22535958]
synonym: "(Ost)2 complex" RELATED []
synonym: "Ost alpha-Ost beta complex" EXACT []
synonym: "SLC51 complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0044732
name: mitotic spindle pole body
namespace: cellular_component
def: "The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome." [GOC:mah, GOC:vw]
is_a: GO:0005816 ! spindle pole body

[Term]
id: GO:0044733
name: envenomation resulting in modulation of acid-sensing ion channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in modulation of acid-sensing ion channel activity in other organism" EXACT []
synonym: "envenomation resulting in modulation of ASIC channel activity in other organism" EXACT []
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism

[Term]
id: GO:0044734
name: envenomation resulting in positive regulation of acid-sensing ion channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism" EXACT []
synonym: "envenomation resulting in positive regulation of ASIC channel activity in other organism" EXACT []
is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in another organism

[Term]
id: GO:0044735
name: envenomation resulting in negative regulation of acid-sensing ion channel activity in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism" EXACT []
synonym: "envenomation resulting in negative regulation of ASIC channel activity in other organism" EXACT []
is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in another organism

[Term]
id: GO:0044736
name: obsolete acid-sensing ion channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex." [GOC:jl]
comment: The reason for obsoletion is that this activity represents a gene family with GO:0160128 pH-gated channel activity.
synonym: "ASIC activity" EXACT []
xref: Wikipedia:Acid-sensing_ion_channel
is_obsolete: true
replaced_by: GO:0160128

[Term]
id: GO:0044737
name: modulation of acid-sensing ion channel in another organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism." [GOC:jl]
synonym: "modulation of acid-sensing ion channel in other organism" EXACT []
synonym: "regulation of acid-sensing ion channel in other organism" EXACT []
synonym: "regulation of ASIC channel in other organism" EXACT []
is_a: GO:0044561 ! modulation of ion channel activity in another organism

[Term]
id: GO:0044738
name: negative regulation of acid-sensing ion channel in another organism
namespace: biological_process
def: "Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl]
synonym: "negative regulation of acid-sensing ion channel in other organism" EXACT []
synonym: "negative regulation of ASIC channel in other organism" EXACT []
is_a: GO:0044737 ! modulation of acid-sensing ion channel in another organism

[Term]
id: GO:0044739
name: positive regulation of acid-sensing ion channel in another organism
namespace: biological_process
def: "Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl]
synonym: "positive regulation of acid-sensing ion channel in other organism" EXACT []
synonym: "positive regulation of ASIC channel in other organism" EXACT []
is_a: GO:0044737 ! modulation of acid-sensing ion channel in another organism

[Term]
id: GO:0044740
name: negative regulation of sensory perception of pain in another organism
namespace: biological_process
def: "A process that negatively regulates the sensory perception of pain in a different organism." [GOC:fj, GOC:jl]
synonym: "inhibition of sensory perception of pain in another organism" EXACT []
synonym: "negative regulation of sensory perception of pain in other organism" EXACT []
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0044465 ! modulation of sensory perception of pain in another organism

[Term]
id: GO:0044741
name: envenomation resulting in negative regulation of sensory perception of pain in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in inhibition of sensory perception of pain in other organism" EXACT []
synonym: "envenomation resulting in negative regulation of sensory perception of pain in other organism" EXACT []
is_a: GO:0044742 ! envenomation resulting in modulation of sensory perception of pain in another organism

[Term]
id: GO:0044742
name: envenomation resulting in modulation of sensory perception of pain in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in modulation of sensory perception of pain in other organism" EXACT []
synonym: "envenomation resulting in regulation of sensory perception of pain in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0044743
name: protein transmembrane import into intracellular organelle
namespace: biological_process
def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]
is_a: GO:0071806 ! protein transmembrane transport
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0044747
name: pre-miRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends." [PMID:22055292, PMID:22055293]
synonym: "mature miRNA 3'-end processing" RELATED []
synonym: "miRNA 3' end terminal trimming" BROAD []
synonym: "miRNA 3'-end processing" BROAD []
synonym: "miRNA trimming" BROAD []
is_a: GO:0031054 ! pre-miRNA processing
is_a: GO:0043628 ! regulatory ncRNA 3'-end processing
relationship: part_of GO:0035196 ! miRNA processing

[Term]
id: GO:0044748
name: 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA." [GOC:sart]
synonym: "exonucleolytic trimming to generate 3' end of miRNA" BROAD []
is_a: GO:0000175 ! 3'-5'-RNA exonuclease activity

[Term]
id: GO:0044750
name: high-affinity nickel cation transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jl]
is_a: GO:0015099 ! nickel cation transmembrane transporter activity

[Term]
id: GO:0044751
name: cellular response to human chorionic gonadotropin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635]
synonym: "cellular response to human chorionic gonadotrophin stimulus" EXACT [GOC:dph]
is_a: GO:0044752 ! response to human chorionic gonadotropin
is_a: GO:0071371 ! cellular response to gonadotropin stimulus

[Term]
id: GO:0044752
name: response to human chorionic gonadotropin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635]
synonym: "response to human chorionic gonadotropin stimulus" EXACT [GOC:dos]
is_a: GO:0034698 ! response to gonadotropin

[Term]
id: GO:0044753
name: amphisome
namespace: cellular_component
def: "Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]
is_a: GO:0005776 ! autophagosome

[Term]
id: GO:0044754
name: autolysosome
namespace: cellular_component
def: "A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome or amphisome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases." [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921, PMID:24657946]
synonym: "AVd" EXACT []
synonym: "degrading autophagic vacuole" EXACT []
xref: NIF_Subcellular:sao8444068431
is_a: GO:0005767 ! secondary lysosome

[Term]
id: GO:0044758
name: symbiont-mediated perturbation of host synaptic transmission
namespace: biological_process
def: "A process in which a symbiont alters or subverts synaptic transmission, the communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl, PMID:26487282, PMID:31075318]
synonym: "modulation by symbiont of host synaptic transmission" EXACT []
synonym: "regulation by symbiont of host synaptic transmission" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0044759
name: symbiont-mediated suppression of host synaptic transmission
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal execution of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl]
synonym: "negative regulation by symbiont of host synaptic transmission" EXACT []
is_a: GO:0044758 ! symbiont-mediated perturbation of host synaptic transmission

[Term]
id: GO:0044760
name: symbiont-mediated perturbation of host cholinergic synaptic transmission
namespace: biological_process
def: "A process in which a symbiont alters or subverts cholinergic synaptic transmission, the communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl]
synonym: "modulation by symbiont of host cholinergic synaptic transmission" EXACT []
synonym: "regulation by symbiont of host cholinergic synaptic transmission" EXACT []
is_a: GO:0044758 ! symbiont-mediated perturbation of host synaptic transmission

[Term]
id: GO:0044761
name: symbiont-mediated suppression of host cholinergic synaptic transmission
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal execution of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl, PMID:37157163]
synonym: "negative regulation by symbiont of host cholinergic synaptic transmission" EXACT []
is_a: GO:0044759 ! symbiont-mediated suppression of host synaptic transmission
is_a: GO:0044760 ! symbiont-mediated perturbation of host cholinergic synaptic transmission

[Term]
id: GO:0044762
name: symbiont-mediated suppression of host neurotransmitter secretion
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the regulated release of a neurotransmitter from a cell in its host organism." [PMID:1328520, PMID:7901002]
synonym: "negative regulation by symbiont of host neurotransmitter secretion" EXACT []
is_a: GO:0044079 ! symbiont-mediated perturbation of host neurotransmitter secretion

[Term]
id: GO:0044764
name: obsolete multi-organism cellular process
namespace: biological_process
def: "OBSOLETE. Any process that is carried out at the cellular level which involves another organism of the same or different species." [GOC:jl]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0044766
name: obsolete multi-organism transport
namespace: biological_process
def: "OBSOLETE. The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0044769
name: ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
namespace: molecular_function
def: "Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism." [GOC:jl]
is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity

[Term]
id: GO:0044770
name: cell cycle phase transition
namespace: biological_process
def: "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle]
synonym: "cell cycle transition" EXACT []
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0044771
name: meiotic cell cycle phase transition
namespace: biological_process
def: "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase." [GOC:mtg_cell_cycle]
synonym: "cell cycle transition" BROAD []
is_a: GO:0044770 ! cell cycle phase transition
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0044772
name: mitotic cell cycle phase transition
namespace: biological_process
def: "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]
subset: goslim_pombe
is_a: GO:0044770 ! cell cycle phase transition
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:0044773
name: mitotic DNA damage checkpoint signaling
namespace: biological_process
alt_id: GO:1902402
def: "A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in mitotic DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "mitotic DNA damage checkpoint" EXACT []
synonym: "signal transduction involved in mitotic DNA damage checkpoint" EXACT []
is_a: GO:0000077 ! DNA damage checkpoint signaling
is_a: GO:0044774 ! mitotic DNA integrity checkpoint signaling

[Term]
id: GO:0044774
name: mitotic DNA integrity checkpoint signaling
namespace: biological_process
alt_id: GO:0070683
alt_id: GO:1902403
def: "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]
synonym: "intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction involved in topo II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in topo II checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in topoisomerase II checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in topo II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in topo II checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in topoisomerase II checkpoint" RELATED [GOC:TermGenie]
synonym: "mitotic cell cycle G2/M transition decatenation checkpoint" EXACT []
synonym: "mitotic DNA integrity checkpoint" EXACT []
synonym: "signal transduction involved in mitotic DNA integrity checkpoint" EXACT []
synonym: "signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in topo II checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling
is_a: GO:0031570 ! DNA integrity checkpoint signaling

[Term]
id: GO:0044775
name: DNA polymerase III, beta sliding clamp processivity factor complex
namespace: cellular_component
def: "A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species." [GOC:jl, UniProt:O73947]
is_a: GO:0044796 ! DNA polymerase processivity factor complex
relationship: part_of GO:0009360 ! DNA polymerase III complex

[Term]
id: GO:0044776
name: DNA polymerase III, core complex
namespace: cellular_component
def: "The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities." [GOC:jl, UniProt:P06710]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0009360 ! DNA polymerase III complex

[Term]
id: GO:0044777
name: single-stranded DNA-binding protein complex
namespace: cellular_component
def: "A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair." [GOC:jl, UniProt:P0AGE0]
synonym: "SSB complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0009295 ! nucleoid

[Term]
id: GO:0044778
name: meiotic DNA integrity checkpoint signaling
namespace: biological_process
def: "A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]
synonym: "meiotic DNA integrity checkpoint" EXACT []
is_a: GO:0031570 ! DNA integrity checkpoint signaling
is_a: GO:0033313 ! meiotic cell cycle checkpoint signaling

[Term]
id: GO:0044779
name: meiotic spindle checkpoint signaling
namespace: biological_process
alt_id: GO:1902398
def: "A signal transduction process that contributes to a cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle." [GOC:mtg_cell_cycle]
synonym: "intracellular signal transduction involved in meiotic spindle checkpoint" EXACT []
synonym: "intracellular signal transduction pathway involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie]
synonym: "meiotic spindle checkpoint" EXACT []
is_a: GO:0031577 ! spindle checkpoint signaling
is_a: GO:0033313 ! meiotic cell cycle checkpoint signaling
is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle

[Term]
id: GO:0044780
name: bacterial-type flagellum assembly
namespace: biological_process
def: "The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl]
synonym: "bacterial flagellum assembly" EXACT []
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0044781 ! bacterial-type flagellum organization
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:0044781
name: bacterial-type flagellum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl]
is_a: GO:0006996 ! organelle organization
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0044782
name: cilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
subset: goslim_drosophila
subset: goslim_generic
synonym: "microtubule-based flagellum organization" EXACT []
is_a: GO:0006996 ! organelle organization
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0044784
name: metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:0044770 ! cell cycle phase transition

[Term]
id: GO:0044785
name: metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis." [GOC:mtg_cell_cycle]
synonym: "meiotic metaphase/anaphase transition" EXACT []
is_a: GO:0044771 ! meiotic cell cycle phase transition
is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle

[Term]
id: GO:0044786
name: cell cycle DNA replication
namespace: biological_process
def: "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0006261 ! DNA-templated DNA replication
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0044787
name: bacterial-type DNA replication
namespace: biological_process
def: "The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome." [GOC:mtg_cell_cycle]
synonym: "bacterial-type cell cycle DNA replication" EXACT []
is_a: GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:0044788
name: modulation by host of viral process
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected." [GOC:jl]
is_a: GO:0051851 ! modulation by host of symbiont process

[Term]
id: GO:0044789
name: obsolete modulation by host of viral release from host cell
namespace: biological_process
def: "OBSOLETE. A process in which a host organism modulates the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167]
comment: This term was obsoleted because there is no evidence that it is a regulated process.
is_obsolete: true
replaced_by: GO:0019076

[Term]
id: GO:0044790
name: suppression of viral release by host
namespace: biological_process
alt_id: GO:1902187
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167]
synonym: "down regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "down regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "down regulation of viral release" EXACT [GOC:TermGenie]
synonym: "down regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "down-regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral release" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "downregulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "downregulation of viral exit" EXACT [GOC:TermGenie]
synonym: "downregulation of viral release" EXACT [GOC:TermGenie]
synonym: "downregulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "inhibition of release of virus from host" EXACT [GOC:TermGenie]
synonym: "inhibition of viral exit" EXACT [GOC:TermGenie]
synonym: "inhibition of viral release" EXACT [GOC:TermGenie]
synonym: "inhibition of viral release from host cell" NARROW [GOC:TermGenie]
synonym: "inhibition of viral shedding" EXACT [GOC:TermGenie]
synonym: "negative regulation by host of viral release from host cell" EXACT []
synonym: "negative regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral release" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral release from host cell" EXACT []
synonym: "negative regulation of viral shedding" EXACT [GOC:TermGenie]
is_a: GO:0051607 ! defense response to virus

[Term]
id: GO:0044791
name: obsolete positive regulation by host of viral release from host cell
namespace: biological_process
def: "OBSOLETE. A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl]
comment: This term was obsoleted because there is no evidence that it is a regulated process.
is_obsolete: true
replaced_by: GO:0019076

[Term]
id: GO:0044793
name: negative regulation by host of viral process
namespace: biological_process
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected." [GOC:jl]
is_a: GO:0044788 ! modulation by host of viral process
relationship: negatively_regulates GO:0016032 ! viral process

[Term]
id: GO:0044794
name: positive regulation by host of viral process
namespace: biological_process
def: "A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected." [GOC:jl]
is_a: GO:0044788 ! modulation by host of viral process
relationship: positively_regulates GO:0016032 ! viral process

[Term]
id: GO:0044795
name: trans-Golgi network to recycling endosome transport
namespace: biological_process
def: "The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes." [GOC:lb, PMID:18779367]
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0044796
name: DNA polymerase processivity factor complex
namespace: cellular_component
def: "A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication." [GOC:bhm, GOC:jl]
is_a: GO:0150005 ! enzyme activator complex

[Term]
id: GO:0044799
name: NarGHI complex
namespace: cellular_component
def: "A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit." [GOC:bhm, PMID:11289299, PMID:12910261, PMID:17964535]
synonym: "cytoplasmic membrane-bound quinol-nitrate oxidoreductase" EXACT []
synonym: "nitrate reductase A" EXACT []
is_a: GO:0009325 ! nitrate reductase complex
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:0098803 ! respiratory chain complex

[Term]
id: GO:0044800
name: obsolete multi-organism membrane fusion
namespace: biological_process
def: "OBSOLETE. The membrane organization process that joins two lipid bilayers to form a single membrane, involving more than one organism." [GOC:jl]
comment: This term was obsoleted because it is not a biologically meaningful grouping class.
is_obsolete: true

[Term]
id: GO:0044803
name: obsolete multi-organism membrane organization
namespace: biological_process
def: "OBSOLETE. A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0044804
name: nucleophagy
namespace: biological_process
def: "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549]
synonym: "autophagy of nucleus" EXACT []
synonym: "late nucleophagy" NARROW []
synonym: "nucleus degradation" RELATED []
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0044805
name: obsolete late nucleophagy
namespace: biological_process
def: "OBSOLETE. A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." [GOC:dgf, GOC:jl, PMID:22768199]
comment: The reason for obsoletion is that this term was added in error (process no different from parent)
is_obsolete: true
replaced_by: GO:0044804

[Term]
id: GO:0044806
name: G-quadruplex DNA unwinding
namespace: biological_process
def: "The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'." [GOC:jl, GOC:se, PMID:23657261]
is_a: GO:0032392 ! DNA geometric change

[Term]
id: GO:0044807
name: macrophage migration inhibitory factor production
namespace: biological_process
def: "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "MIF production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0044808
name: oncostatin M production
namespace: biological_process
def: "The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "OSM production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0044809
name: chemokine (C-C motif) ligand 17 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL17 production" EXACT []
synonym: "TARC production" EXACT []
synonym: "thymus and activation regulated chemokine production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0044812
name: fermentative hydrogen production
namespace: biological_process
def: "The fermentation of organic substances with a net release of hydrogen." [GOC:mengo_curators]
synonym: "carbohydrate fermentation" EXACT []
xref: Wikipedia:Fermentative_hydrogen_production
is_a: GO:0006113 ! fermentation
is_a: GO:1902422 ! hydrogen biosynthetic process

[Term]
id: GO:0044813
name: glycolytic fermentation via PFOR pathway
namespace: biological_process
def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species." [GOC:mengo_curators, PMID:20395274, PMID:20692761]
xref: MetaCyc:CENTFERM-PWY
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0044814
name: glycolytic fermentation via PFL pathway
namespace: biological_process
def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli." [GOC:mengo_curators, PMID:20395274, PMID:20692761]
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0044815
name: obsolete DNA packaging complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that plays a role in the process of DNA packaging." [GOC:jl]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0044816
name: Nsk1-Dlc1 complex
namespace: cellular_component
def: "A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation." [GOC:vw, PMID:22065639]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0044817
name: hydrogen generation via biophotolysis
namespace: biological_process
def: "The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae." [GOC:mengo_curators, PMID:20395274, PMID:20692761]
synonym: "hydrogen biosynthesis via biophotolysis" EXACT []
is_a: GO:1902422 ! hydrogen biosynthetic process

[Term]
id: GO:0044818
name: mitotic G2/M transition checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling
is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle

[Term]
id: GO:0044819
name: mitotic G1/S transition checkpoint signaling
namespace: biological_process
def: "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
synonym: "mitotic G1/S transition checkpoint" EXACT []
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling
is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle

[Term]
id: GO:0044820
name: mitotic telomere tethering at nuclear periphery
namespace: biological_process
def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:25778919]
is_a: GO:0034398 ! telomere tethering at nuclear periphery
relationship: part_of GO:0120109 ! mitotic telomere clustering and tethering at nuclear periphery

[Term]
id: GO:0044821
name: meiotic telomere tethering at nuclear periphery
namespace: biological_process
def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0034398 ! telomere tethering at nuclear periphery
is_a: GO:0045141 ! meiotic telomere clustering

[Term]
id: GO:0044823
name: retroviral integrase activity
namespace: molecular_function
def: "Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism." [PMID:19091057]
is_a: GO:0008907 ! integrase activity

[Term]
id: GO:0044824
name: retroviral 3' processing activity
namespace: molecular_function
def: "The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls." [PMID:22580823]
comment: This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification.
synonym: "3' processing reaction" EXACT []
synonym: "3'-processing activity" EXACT []
is_a: GO:0004520 ! DNA endonuclease activity
relationship: part_of GO:0044823 ! retroviral integrase activity

[Term]
id: GO:0044825
name: obsolete retroviral strand transfer activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction." [PMID:22580823]
comment: This term was obsoleted because it represents part of an activity.
synonym: "strand transfer reaction" EXACT []
is_obsolete: true
consider: GO:0044823

[Term]
id: GO:0044826
name: viral genome integration into host DNA
namespace: biological_process
def: "The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses." [PMID:19091057]
synonym: "viral genome integration" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0044827
name: modulation by host of viral genome replication
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of viral genome replication." [GOC:jl]
synonym: "regulation by host of viral genome reproduction" EXACT []
is_a: GO:0044788 ! modulation by host of viral process
relationship: regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0044828
name: negative regulation by host of viral genome replication
namespace: biological_process
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication." [GOC:jl]
is_a: GO:0044793 ! negative regulation by host of viral process
is_a: GO:0044827 ! modulation by host of viral genome replication
relationship: negatively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0044829
name: positive regulation by host of viral genome replication
namespace: biological_process
def: "A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication." [GOC:jl]
is_a: GO:0044794 ! positive regulation by host of viral process
is_a: GO:0044827 ! modulation by host of viral genome replication
relationship: positively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0044830
name: modulation by host of viral RNA genome replication
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication." [GOC:jl]
synonym: "regulation by host of viral RNA genome replication" EXACT []
is_a: GO:0044827 ! modulation by host of viral genome replication
relationship: regulates GO:0039694 ! viral RNA genome replication

[Term]
id: GO:0044831
name: obsolete modulation by virus of host cytokine production
namespace: biological_process
def: "OBSOLETE. Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0044832
name: obsolete induction by virus of host cytokine production
namespace: biological_process
def: "OBSOLETE. The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation by virus of host cytokine production" EXACT []
is_obsolete: true

[Term]
id: GO:0044833
name: obsolete modulation by virus of host protein transport
namespace: biological_process
def: "OBSOLETE. Any viral process that modulates the frequency, rate or extent of protein transport in its host organism." [GOC:jl, PMID:22334672]
comment: This term was obsoleted because its definition was too vague.
is_obsolete: true

[Term]
id: GO:0044834
name: retroviral intasome
namespace: cellular_component
def: "A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome." [PMID:20118915]
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0044835
name: hydrogen generation via nitrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria." [GOC:mengo_curators, PMID:22128188]
is_a: GO:1902422 ! hydrogen biosynthetic process

[Term]
id: GO:0044836
name: obsolete D-xylose fermentation
namespace: biological_process
def: "OBSOLETE. The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP." [GOC:mengo_curators]
comment: The reason for obsoletion is that the term is not clearly different from its parent term xylose catabolic process to ethanol.
is_obsolete: true
replaced_by: GO:0044577

[Term]
id: GO:0044837
name: actomyosin contractile ring organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring." [GOC:mtg_cell_cycle]
synonym: "cytokinesis, actomyosin contractile ring organization" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0044838
name: cell quiescence
namespace: biological_process
def: "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed." [GOC:jb, GOC:mah]
comment: Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Also, note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "cell cycle quiescence" RELATED [GOC:mah]
synonym: "cellular quiescence" EXACT [GOC:mah]
synonym: "G0 phase" RELATED [GOC:mah]
synonym: "quiescence" BROAD [GOC:mah]
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0044839
name: cell cycle G2/M phase transition
namespace: biological_process
def: "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle]
is_a: GO:0044770 ! cell cycle phase transition

[Term]
id: GO:0044840
name: gut granule
namespace: cellular_component
def: "A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage." [GOC:kmv, PMID:22916203, PMID:24204312]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0044841
name: gut granule membrane
namespace: cellular_component
def: "The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0044840 ! gut granule

[Term]
id: GO:0044842
name: gut granule lumen
namespace: cellular_component
def: "The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0044840 ! gut granule

[Term]
id: GO:0044843
name: cell cycle G1/S phase transition
namespace: biological_process
def: "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle]
is_a: GO:0044770 ! cell cycle phase transition

[Term]
id: GO:0044844
name: meiotic interphase II
namespace: biological_process
def: "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge." [GOC:jl, GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051328 ! meiotic interphase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0044845
name: chain elongation of O-linked mannose residue
namespace: biological_process
def: "Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules." [GOC:jl, PMID:19429925]
comment: Example annotations to this term include the S. cerevisiae alpha1,2-mannosyltransferases ScKre2p, ScKtr1p and ScKtr3pof the KTR family.
is_a: GO:0035268 ! protein mannosylation

[Term]
id: GO:0044846
name: obsolete negative regulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation by symbiont of auxin levels in host" EXACT []
synonym: "negative regulation by symbiont of IAA levels in host" EXACT []
is_obsolete: true

[Term]
id: GO:0044847
name: iron acquisition from host
namespace: biological_process
alt_id: GO:0052099
def: "The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell." [PMID:15487950, PMID:22865843]
synonym: "acquisition by organism of nutrients from host via siderophores" RELATED []
synonym: "acquisition by symbiont of nutrients from host via siderophores" NARROW []
synonym: "heme acquisition" RELATED []
synonym: "iron acquisition" BROAD []
synonym: "iron acquisition by symbiont from host" EXACT []
synonym: "iron acquisition by symbiont from host heme" NARROW []
is_a: GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0044848
name: biological phase
namespace: biological_process
def: "A distinct period or stage in a biological process or cycle." [GOC:jl]
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
subset: gocheck_do_not_annotate
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0044849
name: estrous cycle
namespace: biological_process
def: "A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur." [GOC:jl, Wikipedia:Estrous_cycle]
xref: Wikipedia:Estrous_cycle
is_a: GO:0042698 ! ovulation cycle

[Term]
id: GO:0044850
name: menstrual cycle
namespace: biological_process
def: "A type of ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:jl]
xref: Wikipedia:Menstrual_cycle
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042698 ! ovulation cycle

[Term]
id: GO:0044851
name: hair cycle phase
namespace: biological_process
def: "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:jl]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0044852
name: obsolete nonrepetitive DNA condensation
namespace: biological_process
def: "OBSOLETE. The process in which chromatin structure of nonrepetitive regions of DNA is compacted prior to and during mitosis in eukaryotic cells." [GOC:jl, PMID:10811823]
comment: This term was obsoleted because is is defined in a negative manner.
synonym: "nonrepetitive DNA packaging" EXACT []
is_obsolete: true

[Term]
id: GO:0044853
name: plasma membrane raft
namespace: cellular_component
def: "A membrane raft that is part of the plasma membrane." [GOC:jl]
is_a: GO:0045121 ! membrane raft
is_a: GO:0098590 ! plasma membrane region

[Term]
id: GO:0044854
name: plasma membrane raft assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft." [GOC:jl]
is_a: GO:0001765 ! membrane raft assembly
is_a: GO:0044857 ! plasma membrane raft organization

[Term]
id: GO:0044855
name: plasma membrane raft distribution
namespace: biological_process
def: "The process that establishes the spatial arrangement of membrane rafts within a plasma membrane." [GOC:jl]
is_a: GO:0031580 ! membrane raft distribution
is_a: GO:0044856 ! plasma membrane raft localization

[Term]
id: GO:0044856
name: plasma membrane raft localization
namespace: biological_process
def: "Any process in which plasma membrane rafts are transported to, or maintained in, a specific location." [GOC:jl]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0051665 ! membrane raft localization

[Term]
id: GO:0044857
name: plasma membrane raft organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts." [GOC:jl]
is_a: GO:0031579 ! membrane raft organization
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0044858
name: plasma membrane raft polarization
namespace: biological_process
def: "The clustering and aggregation of a plasma membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [GOC:jl]
synonym: "plasma membrane polarization" EXACT []
is_a: GO:0001766 ! membrane raft polarization
is_a: GO:0044855 ! plasma membrane raft distribution

[Term]
id: GO:0044859
name: protein insertion into plasma membrane raft
namespace: biological_process
def: "The process in which a protein is incorporated into a plasma membrane raft." [GOC:jl]
is_a: GO:0044860 ! protein localization to plasma membrane raft
is_a: GO:0071210 ! protein insertion into membrane raft
is_a: GO:0098737 ! protein insertion into plasma membrane

[Term]
id: GO:0044860
name: protein localization to plasma membrane raft
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft." [GOC:jl]
is_a: GO:1903044 ! protein localization to membrane raft
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0044861
name: protein transport into plasma membrane raft
namespace: biological_process
def: "The directed movement of a protein into a plasma membrane raft." [GOC:jl]
is_a: GO:0032596 ! protein transport into membrane raft
is_a: GO:0044860 ! protein localization to plasma membrane raft

[Term]
id: GO:0044862
name: protein transport out of plasma membrane raft
namespace: biological_process
def: "The directed movement of a protein out of a plasma membrane raft." [GOC:jl]
is_a: GO:0032599 ! protein transport out of membrane raft
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:0099632 ! protein transport within plasma membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0044863
name: obsolete modulation by virus of host cell division
namespace: biological_process
def: "OBSOLETE. Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells." [GOC:jl]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "regulation by virus of host cell division" EXACT []
is_obsolete: true

[Term]
id: GO:0044864
name: obsolete positive regulation by virus of host cell division
namespace: biological_process
def: "OBSOLETE. Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division." [GOC:jl]
comment: This term was obsoleted because it represents the same process as transformation of host cell by virus ; GO:0019087.
is_obsolete: true
replaced_by: GO:0019087

[Term]
id: GO:0044865
name: symbiont-mediated suppression of host cell division
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal execution of cell division in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24218612]
synonym: "inhibition by virus of host cell division" NARROW []
synonym: "negative regulation by virus of host cell division" NARROW []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0044866
name: modulation by host of viral exo-alpha-sialidase activity
namespace: biological_process
def: "The process in which a host organism effects a change in viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl]
is_a: GO:0044867 ! modulation by host of viral catalytic activity

[Term]
id: GO:0044867
name: modulation by host of viral catalytic activity
namespace: biological_process
def: "The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected." [GOC:jl]
is_a: GO:0044868 ! modulation by host of viral molecular function

[Term]
id: GO:0044868
name: modulation by host of viral molecular function
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected." [GOC:jl]
is_a: GO:0044788 ! modulation by host of viral process

[Term]
id: GO:0044869
name: obsolete negative regulation by host of viral exo-alpha-sialidase activity
namespace: biological_process
def: "OBSOLETE. The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0044870
name: modulation by host of viral glycoprotein metabolic process
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl]
is_a: GO:0044788 ! modulation by host of viral process
relationship: regulates GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0044871
name: negative regulation by host of viral glycoprotein metabolic process
namespace: biological_process
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl]
is_a: GO:0044793 ! negative regulation by host of viral process
is_a: GO:0044870 ! modulation by host of viral glycoprotein metabolic process
is_a: GO:0048525 ! negative regulation of viral process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process

[Term]
id: GO:0044872
name: lipoprotein localization
namespace: biological_process
def: "Any process in which a lipoprotein is transported to, or maintained in, a specific location." [GOC:jl]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0044873
name: lipoprotein localization to membrane
namespace: biological_process
def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane." [GOC:jl]
is_a: GO:0044872 ! lipoprotein localization
is_a: GO:0072657 ! protein localization to membrane

[Term]
id: GO:0044874
name: lipoprotein localization to outer membrane
namespace: biological_process
def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane." [GOC:jl]
is_a: GO:0044873 ! lipoprotein localization to membrane

[Term]
id: GO:0044875
name: gamma-glutamyl hercynylcysteine sulfoxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577, RHEA:42672]
synonym: "gamma-glutamyl hercynylcysteine S-oxide synthase" EXACT [GOC:dph]
synonym: "gamma-glutamyl hercynylcysteine sulfoxide synthase" EXACT []
xref: EC:1.14.99.50
xref: RHEA:42672
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0044876
name: obsolete hercynylselenocysteine synthase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 = 2 H2O + 2 hercynylselenocysteine." [GOC:jl, PMID:24828577]
comment: This term was obsoleted based on PMID:36071162 that has demonstrated that this reaction does not take place.
is_obsolete: true

[Term]
id: GO:0044877
name: protein-containing complex binding
namespace: molecular_function
alt_id: GO:0032403
def: "Binding to a macromolecular complex." [GOC:jl]
subset: goslim_chembl
synonym: "macromolecular complex binding" RELATED []
synonym: "protein complex binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0044878
name: mitotic cytokinesis checkpoint signaling
namespace: biological_process
alt_id: GO:1903820
def: "A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed." [GOC:jl, GOC:mtg_cell_cycle, PMID:17538026]
synonym: "cytokinesis after mitosis checkpoint" RELATED [GOC:dph, GOC:vw]
synonym: "defective cytokinesis checkpoint" RELATED [GOC:dph, GOC:vw]
synonym: "mitotic cytokinesis checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cytokinesis checkpoint" EXACT []
synonym: "signaling pathway involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "signalling cascade involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "signalling pathway involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling
is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle

[Term]
id: GO:0044879
name: mitotic morphogenesis checkpoint signaling
namespace: biological_process
alt_id: GO:1903822
def: "A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth." [GOC:jl, GOC:mtg_cell_cycle]
synonym: "morphogenesis checkpoint" EXACT []
synonym: "septin checkpoint" EXACT []
synonym: "signal transduction involved in morphogenesis checkpoint" EXACT []
synonym: "signal transduction involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "signaling cascade involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "signaling cascade involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "signaling pathway involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "signaling pathway involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "signalling cascade involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "signalling cascade involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "signalling pathway involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "signalling pathway involved in septin checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling

[Term]
id: GO:0045002
name: double-strand break repair via single-strand annealing
namespace: biological_process
def: "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529]
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0045003
name: double-strand break repair via synthesis-dependent strand annealing
namespace: biological_process
def: "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]
synonym: "mitotic gene conversion" RELATED []
synonym: "SDSA" BROAD []
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0045004
name: DNA replication proofreading
namespace: biological_process
def: "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]
is_a: GO:0006281 ! DNA repair
is_a: GO:0045005 ! DNA-templated DNA replication maintenance of fidelity

[Term]
id: GO:0045005
name: DNA-templated DNA replication maintenance of fidelity
namespace: biological_process
def: "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw]
synonym: "DNA-dependent DNA replication maintenance of fidelity" EXACT []
synonym: "maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of fidelity involved in DNA-dependent DNA replication" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0045006
name: DNA deamination
namespace: biological_process
def: "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai]
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0045007
name: depurination
namespace: biological_process
def: "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai]
xref: Wikipedia:Depurination
is_a: GO:0006285 ! base-excision repair, AP site formation
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0045008
name: depyrimidination
namespace: biological_process
def: "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai]
is_a: GO:0006285 ! base-excision repair, AP site formation
is_a: GO:0006304 ! DNA modification
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process

[Term]
id: GO:0045009
name: chitosome
namespace: cellular_component
def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732, PMID:8970154]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0045010
name: actin nucleation
namespace: biological_process
def: "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]
synonym: "actin filament nucleation" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0045012
name: obsolete MHC class II receptor activity
namespace: molecular_function
def: "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971]
comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'.
synonym: "class II major histocompatibility complex antigen" RELATED []
synonym: "major histocompatibility complex class II receptor" EXACT []
synonym: "MHC class II receptor activity" EXACT []
is_obsolete: true
consider: GO:0032395
consider: GO:0042613

[Term]
id: GO:0045013
name: carbon catabolite repression of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah, ISBN:0198506732, PMID:11018147, PMID:18359269, PMID:9618445]
synonym: "carbon catabolite repression" RELATED [GOC:dph]
synonym: "negative regulation of transcription by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
is_a: GO:0045990 ! carbon catabolite regulation of transcription
is_a: GO:0061985 ! carbon catabolite repression

[Term]
id: GO:0045014
name: carbon catabolite repression of transcription by glucose
namespace: biological_process
def: "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [ISBN:0198506732, PMID:11018147]
synonym: "down regulation of transcription by glucose" EXACT []
synonym: "down-regulation of transcription by glucose" EXACT []
synonym: "downregulation of transcription by glucose" EXACT []
synonym: "glucose effect" EXACT []
synonym: "glucose repression" EXACT []
synonym: "inhibition of transcription by glucose" NARROW []
is_a: GO:0045013 ! carbon catabolite repression of transcription
is_a: GO:0061986 ! negative regulation of transcription by glucose

[Term]
id: GO:0045015
name: HDEL sequence binding
namespace: molecular_function
def: "Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759]
synonym: "HDEL receptor activity" NARROW []
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0045016
name: mitochondrial magnesium ion transmembrane transport
namespace: biological_process
alt_id: GO:1990614
def: "The process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai, PMID:11254124]
synonym: "mitochondrial magnesium ion transport" RELATED []
is_a: GO:1903830 ! magnesium ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0045017
name: glycerolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
synonym: "glycerolipid anabolism" EXACT []
synonym: "glycerolipid biosynthesis" EXACT []
synonym: "glycerolipid formation" EXACT []
synonym: "glycerolipid synthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0045018
name: retrograde transport, vacuole to Golgi
namespace: biological_process
def: "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156]
synonym: "retrograde transport from the vacuole" EXACT []
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0045019
name: negative regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "down regulation of nitric oxide biosynthetic process" EXACT []
synonym: "down-regulation of nitric oxide biosynthetic process" EXACT []
synonym: "downregulation of nitric oxide biosynthetic process" EXACT []
synonym: "inhibition of nitric oxide biosynthetic process" NARROW []
synonym: "negative regulation of nitric oxide anabolism" EXACT []
synonym: "negative regulation of nitric oxide biosynthesis" EXACT []
synonym: "negative regulation of nitric oxide formation" EXACT []
synonym: "negative regulation of nitric oxide synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process
is_a: GO:1904406 ! negative regulation of nitric oxide metabolic process
relationship: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045020
name: obsolete error-prone DNA repair
namespace: biological_process
def: "OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974]
comment: This term was made obsolete because 'error-prone' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
synonym: "error-prone DNA repair" EXACT []
synonym: "mutagenic DNA repair" EXACT []
is_obsolete: true
consider: GO:0042276

[Term]
id: GO:0045021
name: obsolete error-free DNA repair
namespace: biological_process
def: "OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974]
comment: This term was made obsolete because 'error-free' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
synonym: "error-free DNA repair" EXACT []
is_obsolete: true
consider: GO:0042275
consider: GO:0070987

[Term]
id: GO:0045022
name: early endosome to late endosome transport
namespace: biological_process
def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]
synonym: "endosome maturation" RELATED [PMID:21878991, PMID:29980602]
is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments

[Term]
id: GO:0045023
name: G0 to G1 transition
namespace: biological_process
def: "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [GOC:mtg_cell_cycle, ISBN:0716731363]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0045024
name: obsolete peptidyl-glutamyl peptide hydrolyzing enzyme activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414]
comment: This term was made obsolete because it represents a gene product.
synonym: "peptidyl-glutamyl peptide hydrolyzing enzyme activity" EXACT []
is_obsolete: true
replaced_by: GO:0008233

[Term]
id: GO:0045025
name: mitochondrial degradosome
namespace: cellular_component
def: "A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer." [PMID:10397341, PMID:9829834]
synonym: "mtEXO" EXACT [PMID:10397341, PMID:9829834]
is_a: GO:0000177 ! cytoplasmic exosome (RNase complex)
is_a: GO:0098798 ! mitochondrial protein-containing complex

[Term]
id: GO:0045026
name: plasma membrane fusion
namespace: biological_process
alt_id: GO:0006947
def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" BROAD []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0061025 ! membrane fusion

[Term]
id: GO:0045027
name: DNA end binding
namespace: molecular_function
def: "Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)." [GOC:jl]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0045028
name: G protein-coupled purinergic nucleotide receptor activity
namespace: molecular_function
def: "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, PMID:9755289]
synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT []
synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT []
synonym: "P2Y" RELATED []
synonym: "P2Y receptor" RELATED [PMID:9755289]
synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT []
synonym: "purinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0001614 ! purinergic nucleotide receptor activity
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0045029
name: G protein-coupled UDP receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP." [GOC:mah]
synonym: "UDP-activated nucleotide receptor activity" BROAD []
is_a: GO:0071553 ! G protein-coupled pyrimidinergic nucleotide receptor activity

[Term]
id: GO:0045030
name: G protein-coupled UTP receptor activity
namespace: molecular_function
alt_id: GO:0015065
def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP." [GOC:mah]
synonym: "purinoceptor type U" BROAD []
synonym: "uridine nucleotide receptor activity" BROAD []
synonym: "UTP-activated nucleotide receptor activity" BROAD []
is_a: GO:0071553 ! G protein-coupled pyrimidinergic nucleotide receptor activity

[Term]
id: GO:0045031
name: G protein-coupled ATP receptor activity
namespace: molecular_function
def: "Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah]
synonym: "ATP-activated adenosine receptor activity" RELATED []
synonym: "ATP-activated nucleotide receptor activity" BROAD []
is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity

[Term]
id: GO:0045033
name: peroxisome inheritance
namespace: biological_process
def: "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545]
comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another.
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0045034
name: obsolete neuroblast division
namespace: biological_process
alt_id: GO:0043345
alt_id: GO:0043346
def: "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167]
comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division.
synonym: "neuroblast cell division" EXACT []
synonym: "neuroblast division" EXACT []
synonym: "neuroblast division (sensu Nematoda and Protostomia)" EXACT []
synonym: "neuroblast division (sensu Vertebrata)" EXACT []
is_obsolete: true

[Term]
id: GO:0045035
name: sensory organ precursor cell division
namespace: biological_process
def: "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
synonym: "sense organ precursor cell division" EXACT [GOC:dph]
is_a: GO:0008356 ! asymmetric cell division
relationship: part_of GO:0007423 ! sensory organ development

[Term]
id: GO:0045036
name: protein targeting to chloroplast
namespace: biological_process
def: "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363]
synonym: "protein-chloroplast targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0072596 ! establishment of protein localization to chloroplast

[Term]
id: GO:0045037
name: protein import into chloroplast stroma
namespace: biological_process
def: "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363]
synonym: "chloroplast stroma protein import" EXACT []
synonym: "protein transport into chloroplast stroma" EXACT []
is_a: GO:0071806 ! protein transmembrane transport
is_a: GO:0072596 ! establishment of protein localization to chloroplast

[Term]
id: GO:0045038
name: protein import into chloroplast thylakoid membrane
namespace: biological_process
def: "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363]
synonym: "chloroplast thylakoid membrane protein import" EXACT []
synonym: "protein transport into chloroplast thylakoid membrane" EXACT []
is_a: GO:0017038 ! protein import
is_a: GO:0044743 ! protein transmembrane import into intracellular organelle
is_a: GO:0072596 ! establishment of protein localization to chloroplast
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0045039
name: protein insertion into mitochondrial inner membrane
namespace: biological_process
def: "The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008]
synonym: "mitochondrial inner membrane protein import" EXACT []
synonym: "protein import into mitochondrial inner membrane" EXACT []
synonym: "protein transport into mitochondrial inner membrane" EXACT []
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0007007 ! inner mitochondrial membrane organization
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0045040
name: protein insertion into mitochondrial outer membrane
namespace: biological_process
def: "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008]
synonym: "mitochondrial outer membrane protein import" EXACT []
synonym: "protein import into mitochondrial outer membrane" EXACT []
synonym: "protein transport into mitochondrial outer membrane" EXACT []
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0007008 ! outer mitochondrial membrane organization
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0045041
name: protein import into mitochondrial intermembrane space
namespace: biological_process
alt_id: GO:0045043
alt_id: GO:0045044
def: "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363]
synonym: "mitochondrial intermembrane space protein import" EXACT []
synonym: "protein import into mitochondrial IMS" EXACT []
synonym: "protein import into mitochondrial intermembrane space, direct" NARROW [GOC:mcc]
synonym: "protein import into mitochondrial intermembrane space, nonconservative" NARROW [GOC:mcc]
synonym: "protein transport into mitochondrial IMS" EXACT []
synonym: "protein transport into mitochondrial intermembrane space" EXACT []
is_a: GO:0044743 ! protein transmembrane import into intracellular organelle
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:1990542 ! mitochondrial transmembrane transport
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0045042
name: obsolete protein import into mitochondrial intermembrane space, conservative
namespace: biological_process
def: "OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363]
comment: This term was made obsolete because there is no 'conservative' process of protein import into the mitochondrial intermembrane space that is distinct from the more general parent; furthermore, 'conservative' is used in the literature to describe a pathway of import into the inner membrane rather than into the intermembrane space.
synonym: "conservative mitochondrial IMS protein import" EXACT []
synonym: "conservative mitochondrial intermembrane space protein import" EXACT []
synonym: "conservative protein transport into mitochondrial IMS" EXACT []
synonym: "conservative protein transport into mitochondrial intermembrane space" EXACT []
synonym: "protein import into mitochondrial IMS, conservative" EXACT []
synonym: "protein import into mitochondrial intermembrane space, conservative" EXACT []
synonym: "protein transport into mitochondrial IMS, conservative" EXACT []
synonym: "protein transport into mitochondrial intermembrane space, conservative" EXACT []
is_obsolete: true
consider: GO:0045039
consider: GO:0045041

[Term]
id: GO:0045045
name: obsolete secretory pathway
namespace: biological_process
def: "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363]
comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations.
synonym: "secretory pathway" EXACT []
is_obsolete: true
replaced_by: GO:0032940

[Term]
id: GO:0045046
name: protein import into peroxisome membrane
namespace: biological_process
def: "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]
synonym: "peroxisome membrane protein import" EXACT []
synonym: "protein transport into peroxisome membrane" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0015919 ! peroxisomal membrane transport
is_a: GO:0072663 ! establishment of protein localization to peroxisome
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0045047
name: protein targeting to ER
namespace: biological_process
def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]
synonym: "protein targeting to endoplasmic reticulum" EXACT []
synonym: "protein-endoplasmic reticulum targeting" EXACT []
synonym: "protein-ER targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum

[Term]
id: GO:0045048
name: protein insertion into ER membrane
namespace: biological_process
def: "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]
synonym: "integral ER membrane protein localization" EXACT []
synonym: "integral ER membrane protein positioning" EXACT []
synonym: "localization of protein in ER membrane" EXACT []
synonym: "positioning of protein in ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane" EXACT []
synonym: "protein-endoplasmic reticulum insertion" EXACT []
synonym: "protein-ER insertion" EXACT []
is_a: GO:0051205 ! protein insertion into membrane
relationship: part_of GO:0007029 ! endoplasmic reticulum organization
relationship: part_of GO:0033365 ! protein localization to organelle

[Term]
id: GO:0045049
name: protein insertion into ER membrane by N-terminal cleaved signal sequence
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363]
synonym: "N-terminal cleaved signal sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence" EXACT []
synonym: "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence" EXACT []
synonym: "protein-ER insertion by N-terminal cleaved signal sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045050
name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363]
synonym: "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence" EXACT []
synonym: "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence" EXACT []
synonym: "protein-ER insertion by stop-transfer membrane-anchor sequence" EXACT []
synonym: "stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045051
name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363]
synonym: "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence" EXACT []
synonym: "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence" EXACT []
synonym: "protein-ER insertion by internal uncleaved signal-anchor sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045052
name: obsolete protein insertion into ER membrane by GPI attachment sequence
namespace: biological_process
def: "OBSOLETE. A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363]
comment: The reason for obsoletion is that this term was added in error.
synonym: "GPI attachment sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence" EXACT []
synonym: "protein insertion into ER membrane, GPI attachment sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by GPI attachment sequence" EXACT []
synonym: "protein-ER insertion by GPI attachment sequence" EXACT []
is_obsolete: true

[Term]
id: GO:0045053
name: protein retention in Golgi apparatus
namespace: biological_process
def: "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]
synonym: "maintenance of protein location in Golgi apparatus" RELATED []
synonym: "protein-Golgi retention" EXACT []
synonym: "retention of protein in Golgi" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0034067 ! protein localization to Golgi apparatus

[Term]
id: GO:0045054
name: constitutive secretory pathway
namespace: biological_process
def: "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363]
synonym: "constitutive exocytosis" EXACT []
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0045055
name: regulated exocytosis
namespace: biological_process
def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]
synonym: "regulated secretory pathway" EXACT []
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0045056
name: transcytosis
namespace: biological_process
def: "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363]
xref: Wikipedia:Transcytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0045057
name: cisternal progression
namespace: biological_process
def: "The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363]
synonym: "cisternal maturation" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0045058
name: T cell selection
namespace: biological_process
def: "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149, PMID:12414722]
synonym: "T lymphocyte selection" EXACT []
synonym: "T-cell selection" EXACT []
synonym: "T-lymphocyte selection" EXACT []
xref: Wikipedia:Thymocyte
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0045059
name: positive thymic T cell selection
namespace: biological_process
def: "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722]
synonym: "positive thymic T lymphocyte selection" EXACT []
synonym: "positive thymic T-cell selection" EXACT []
synonym: "positive thymic T-lymphocyte selection" EXACT []
is_a: GO:0043368 ! positive T cell selection
is_a: GO:0045061 ! thymic T cell selection

[Term]
id: GO:0045060
name: negative thymic T cell selection
namespace: biological_process
def: "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722]
synonym: "negative thymic T lymphocyte selection" EXACT []
synonym: "negative thymic T-cell selection" EXACT []
synonym: "negative thymic T-lymphocyte selection" EXACT []
is_a: GO:0043383 ! negative T cell selection
is_a: GO:0045061 ! thymic T cell selection

[Term]
id: GO:0045061
name: thymic T cell selection
namespace: biological_process
def: "The process of T cell selection that occurs in the thymus." [ISBN:0781735149, PMID:12414722]
synonym: "thymic T lymphocyte selection" EXACT []
synonym: "thymic T-cell selection" EXACT []
synonym: "thymic T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0045062
name: extrathymic T cell selection
namespace: biological_process
def: "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149, PMID:7880383]
synonym: "extrathymic T lymphocyte selection" EXACT []
synonym: "extrathymic T-cell selection" EXACT []
synonym: "extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0045063
name: T-helper 1 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:ebc]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T-helper 1 cell development" RELATED [GOC:add]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0045064
name: T-helper 2 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [CL:0000546, GOC:ebc]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T-helper 2 cell development" RELATED [GOC:add]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0042092 ! type 2 immune response

[Term]
id: GO:0045065
name: cytotoxic T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "cytotoxic T cell development" RELATED [GOC:add]
synonym: "cytotoxic T lymphocyte selection" EXACT []
synonym: "cytotoxic T-cell selection" EXACT []
synonym: "cytotoxic T-lymphocyte selection" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0045066
name: regulatory T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulatory T cell development" RELATED [GOC:add]
synonym: "regulatory T lymphocyte differentiation" EXACT []
synonym: "regulatory T-cell differentiation" EXACT []
synonym: "regulatory T-lymphocyte differentiation" EXACT []
synonym: "suppressor T cell differentiation" EXACT []
synonym: "suppressor T lymphocyte differentiation" EXACT []
synonym: "suppressor T-cell differentiation" EXACT []
synonym: "suppressor T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0045067
name: positive extrathymic T cell selection
namespace: biological_process
def: "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:7880383]
synonym: "positive extrathymic T lymphocyte selection" EXACT []
synonym: "positive extrathymic T-cell selection" EXACT []
synonym: "positive extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0043368 ! positive T cell selection
is_a: GO:0045062 ! extrathymic T cell selection

[Term]
id: GO:0045068
name: negative extrathymic T cell selection
namespace: biological_process
def: "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:7880383]
synonym: "negative extrathymic T lymphocyte selection" EXACT []
synonym: "negative extrathymic T-cell selection" EXACT []
synonym: "negative extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0043383 ! negative T cell selection
is_a: GO:0045062 ! extrathymic T cell selection

[Term]
id: GO:0045069
name: regulation of viral genome replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai]
is_a: GO:1903900 ! regulation of viral life cycle
relationship: regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045070
name: positive regulation of viral genome replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai]
synonym: "activation of viral genome replication" NARROW []
synonym: "stimulation of viral genome replication" NARROW []
synonym: "up regulation of viral genome replication" EXACT []
synonym: "up-regulation of viral genome replication" EXACT []
synonym: "upregulation of viral genome replication" EXACT []
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:0048524 ! positive regulation of viral process
relationship: positively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045071
name: negative regulation of viral genome replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators]
synonym: "down regulation of viral genome replication" EXACT []
synonym: "down-regulation of viral genome replication" EXACT []
synonym: "downregulation of viral genome replication" EXACT []
synonym: "inhibition of viral genome replication" NARROW []
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:0048525 ! negative regulation of viral process
relationship: negatively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045087
name: innate immune response
namespace: biological_process
alt_id: GO:0002226
def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
synonym: "innate immunity" EXACT [GOC:pg]
synonym: "nonspecific immune response" EXACT []
xref: Wikipedia:Innate_immune_system
is_a: GO:0006955 ! immune response
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0045088
name: regulation of innate immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045089
name: positive regulation of innate immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
synonym: "stimulation of innate immune response" NARROW []
synonym: "up regulation of innate immune response" EXACT []
synonym: "up-regulation of innate immune response" EXACT []
synonym: "upregulation of innate immune response" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045091
name: regulation of single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators]
synonym: "regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl]
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:2001141 ! regulation of RNA biosynthetic process
relationship: regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate

[Term]
id: GO:0045092
name: interleukin-18 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435]
synonym: "IL-18 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0045093
name: obsolete interleukin-18 alpha subunit binding
namespace: molecular_function
def: "OBSOLETE. Binding to alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850]
comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits
synonym: "IL-18Ra binding" EXACT []
is_obsolete: true

[Term]
id: GO:0045094
name: obsolete interleukin-18 beta subunit binding
namespace: molecular_function
def: "OBSOLETE. Binding to beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850]
comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits.
synonym: "IL-18Rb binding" EXACT []
is_obsolete: true

[Term]
id: GO:0045095
name: keratin filament
namespace: cellular_component
def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]
synonym: "acidic keratin" RELATED []
synonym: "basic/neutral keratin" RELATED []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045096
name: obsolete acidic keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "acidic keratin" EXACT []
synonym: "type I intermediate filament" EXACT []
is_obsolete: true
replaced_by: GO:0045095

[Term]
id: GO:0045097
name: obsolete basic/neutral keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "basic/neutral keratin" EXACT []
synonym: "type II intermediate filament" EXACT []
is_obsolete: true
replaced_by: GO:0045095

[Term]
id: GO:0045098
name: type III intermediate filament
namespace: cellular_component
def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363]
synonym: "desmin" NARROW []
synonym: "glial fibrillary acidic protein" NARROW []
synonym: "peripherin" NARROW []
synonym: "type III intermediate filament associated protein" NARROW []
synonym: "vimentin" NARROW []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045099
name: obsolete vimentin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
synonym: "vimentin" EXACT []
is_obsolete: true
replaced_by: GO:0045098

[Term]
id: GO:0045100
name: obsolete desmin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "desmin" EXACT []
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045101
name: obsolete glial fibrillary acidic protein
namespace: cellular_component
def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
synonym: "GFAP" EXACT []
synonym: "glial fibrillary acidic protein" EXACT []
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045102
name: obsolete peripherin
namespace: cellular_component
def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
synonym: "peripherin" EXACT []
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045103
name: intermediate filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0045104
name: intermediate filament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]
synonym: "intermediate filament cytoskeleton organisation" EXACT []
synonym: "intermediate filament cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0045103 ! intermediate filament-based process

[Term]
id: GO:0045105
name: intermediate filament polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai]
is_a: GO:0043933 ! protein-containing complex organization
relationship: part_of GO:0045104 ! intermediate filament cytoskeleton organization

[Term]
id: GO:0045106
name: intermediate filament depolymerization
namespace: biological_process
def: "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363]
is_a: GO:0045105 ! intermediate filament polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0045107
name: intermediate filament polymerization
namespace: biological_process
def: "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884]
is_a: GO:0045105 ! intermediate filament polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0045108
name: regulation of intermediate filament polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0045105 ! intermediate filament polymerization or depolymerization

[Term]
id: GO:0045109
name: intermediate filament organization
namespace: biological_process
def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai]
synonym: "intermediate filament organisation" EXACT []
is_a: GO:0045104 ! intermediate filament cytoskeleton organization
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0045110
name: intermediate filament bundle assembly
namespace: biological_process
def: "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363]
synonym: "tonofilament assembly" NARROW []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0045109 ! intermediate filament organization

[Term]
id: GO:0045111
name: intermediate filament cytoskeleton
namespace: cellular_component
def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0045112
name: integrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732]
synonym: "integrin anabolism" EXACT []
synonym: "integrin biosynthesis" EXACT []
synonym: "integrin formation" EXACT []
synonym: "integrin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0045113
name: regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "regulation of integrin anabolism" EXACT []
synonym: "regulation of integrin biosynthesis" EXACT []
synonym: "regulation of integrin formation" EXACT []
synonym: "regulation of integrin synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045114
name: beta 2 integrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators]
synonym: "beta 2 integrin anabolism" EXACT []
synonym: "beta 2 integrin biosynthesis" EXACT []
synonym: "beta 2 integrin formation" EXACT []
synonym: "beta 2 integrin synthesis" EXACT []
is_a: GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045115
name: regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "regulation of beta 2 integrin anabolism" EXACT []
synonym: "regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "regulation of beta 2 integrin formation" EXACT []
synonym: "regulation of beta 2 integrin synthesis" EXACT []
is_a: GO:0045113 ! regulation of integrin biosynthetic process
relationship: regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045116
name: protein neddylation
namespace: biological_process
alt_id: GO:0019943
def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]
comment: Note that currently, the only known substrates of neddylation are cullin family proteins.
synonym: "RUB1-protein conjugation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0045117
name: azole transmembrane transport
namespace: biological_process
def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]
synonym: "azole transport" RELATED []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0045119
name: azole:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, ISBN:3527307206, Wikipedia:Azole]
synonym: "azole:hydrogen antiporter activity" EXACT []
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW []
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:0045120
name: pronucleus
namespace: cellular_component
def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732]
xref: Wikipedia:Pronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0045121
name: membrane raft
namespace: cellular_component
def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]
synonym: "GEM domain" RELATED []
synonym: "glycolipid-enriched membrane domain" RELATED []
synonym: "lipid raft" EXACT []
xref: Wikipedia:Lipid_raft
is_a: GO:0098857 ! membrane microdomain

[Term]
id: GO:0045122
name: aflatoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194, PMID:15006741]
synonym: "aflatoxin anabolism" EXACT []
synonym: "aflatoxin biosynthesis" EXACT []
synonym: "aflatoxin formation" EXACT []
synonym: "aflatoxin synthesis" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046222 ! aflatoxin metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:0045123
name: cellular extravasation
namespace: biological_process
def: "The migration of a leukocyte from the blood vessels into the surrounding tissue." [GOC:jl]
synonym: "immune cell cellular extravasation" EXACT []
synonym: "leucocyte cellular extravasation" EXACT []
synonym: "leukocyte cellular extravasation" EXACT []
synonym: "transendothelial leukocyte migration" EXACT [GOC:rl]
xref: Wikipedia:Leukocyte_extravasation
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0045124
name: regulation of bone resorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai]
is_a: GO:0046850 ! regulation of bone remodeling
relationship: regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045125
name: bioactive lipid receptor activity
namespace: molecular_function
def: "Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes." [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0045127
name: N-acetylglucosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + H+." [RHEA:17417]
synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" RELATED [EC:2.7.1.59]
synonym: "acetylaminodeoxyglucokinase activity" RELATED [EC:2.7.1.59]
synonym: "acetylglucosamine kinase (phosphorylating)" RELATED [EC:2.7.1.59]
synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.59]
synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" RELATED [EC:2.7.1.59]
synonym: "GlcNAc kinase activity" RELATED [EC:2.7.1.59]
xref: EC:2.7.1.59
xref: KEGG_REACTION:R01201
xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN
xref: Reactome:R-HSA-6803771 "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P"
xref: RHEA:17417
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0045128
name: negative regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of meiotic recombination" EXACT []
synonym: "down-regulation of meiotic recombination" EXACT []
synonym: "downregulation of meiotic recombination" EXACT []
synonym: "inhibition of meiotic recombination" NARROW []
synonym: "suppression of meiotic recombination" EXACT []
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
is_a: GO:0045910 ! negative regulation of DNA recombination
relationship: negatively_regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0045129
name: obsolete NAD-independent histone deacetylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone." [PMID:28450737]
comment: This term was obsoleted because it represents the same activity as histone deacetylase activity, hydrolytic mechanism ; GO:0004407.
synonym: "AcuC" RELATED []
is_obsolete: true
replaced_by: GO:0004407

[Term]
id: GO:0045130
name: keratan sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21]
synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" RELATED [EC:2.8.2.21]
synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" RELATED [EC:2.8.2.21]
synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" RELATED [EC:2.8.2.21]
synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT []
synonym: "keratan sulfate sulfotransferase activity" RELATED [EC:2.8.2.21]
synonym: "keratan sulphotransferase activity" EXACT []
xref: EC:2.8.2.21
xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-2046175 "Further sulfation on galactose residues produces KSPG"
is_a: GO:0050698 ! proteoglycan sulfotransferase activity

[Term]
id: GO:0045131
name: pre-mRNA branch point binding
namespace: molecular_function
def: "Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632]
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0045132
name: meiotic chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
is_a: GO:0098813 ! nuclear chromosome segregation
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0045133
name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H+." [EC:1.13.11.14, RHEA:18477]
synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" RELATED [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoate oxygenase activity" RELATED [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoic oxygenase activity" RELATED [EC:1.13.11.14]
synonym: "o-pyrocatechuate oxygenase activity" RELATED [EC:1.13.11.14]
xref: EC:1.13.11.14
xref: KEGG_REACTION:R01507
xref: MetaCyc:1.13.11.14-RXN
xref: RHEA:18477
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0045134
name: UDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]
synonym: "UDP phosphohydrolase activity" EXACT [KEGG_REACTION:R00155]
synonym: "UDPase activity" RELATED []
synonym: "uridine 5'-diphosphatase activity" RELATED []
synonym: "uridine diphosphatase activity" RELATED []
synonym: "uridine-diphosphatase activity" EXACT []
xref: KEGG_REACTION:R00155
xref: MetaCyc:RXN-12197
xref: RHEA:64876
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0045135
name: poly(beta-D-mannuronate) lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3]
synonym: "alginase activity" RELATED [EC:4.2.2.3]
synonym: "alginase I" RELATED [EC:4.2.2.3]
synonym: "alginate lyase activity" RELATED [EC:4.2.2.3]
synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3]
synonym: "poly(beta-D-1,4-mannuronide) lyase activity" RELATED [EC:4.2.2.3]
synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3]
xref: EC:4.2.2.3
xref: MetaCyc:4.2.2.3-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0045136
name: development of secondary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0045137
name: development of primary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0045138
name: nematode male tail tip morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome." [GOC:kmv, PMID:16806150, PMID:18050419, PMID:21408209, PMID:7409314]
synonym: "male tail morphogenesis" BROAD []
synonym: "male tail tip morphogenesis" RELATED [GOC:kmv]
synonym: "tail tip morphogenesis" RELATED [GOC:kmv]
is_a: GO:0090598 ! male anatomical structure morphogenesis

[Term]
id: GO:0045139
name: obsolete copper sensitivity/resistance
namespace: biological_process
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "copper sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046688

[Term]
id: GO:0045140
name: inositol phosphoceramide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol." [PMID:9405490, PMID:9614099]
synonym: "IPC synthase activity" EXACT []
xref: EC:2.7.1.227
xref: MetaCyc:RXN3O-581
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0045141
name: meiotic telomere clustering
namespace: biological_process
def: "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis." [GOC:vw, PMID:10690419]
synonym: "bouquet biosynthesis" NARROW []
synonym: "bouquet formation" NARROW []
is_a: GO:0034397 ! telomere localization
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:0090220 ! chromosome localization to nuclear envelope involved in homologous chromosome segregation

[Term]
id: GO:0045142
name: triplex DNA binding
namespace: molecular_function
def: "Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0045143
name: homologous chromosome segregation
namespace: biological_process
alt_id: GO:0007061
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194]
synonym: "meiosis I, chromosome segregation" EXACT []
is_a: GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0045144
name: meiotic sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]
synonym: "meiosis II, chromosome segregation" EXACT []
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:0045132 ! meiotic chromosome segregation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0045145
name: single-stranded DNA 5'-3' DNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101]
synonym: "single-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific 5'-3' exodeoxyribonuclease activity" RELATED [GOC:mah]
xref: EC:3.1.11.4
is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity
is_a: GO:0035312 ! 5'-3' DNA exonuclease activity

[Term]
id: GO:0045146
name: initiation of acetate catabolic process by acetate
namespace: biological_process
def: "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859]
synonym: "initiation of acetate breakdown by acetate" EXACT []
synonym: "initiation of acetate degradation by acetate" EXACT []
is_a: GO:0043077 ! initiation of acetate catabolic process
relationship: part_of GO:0010034 ! response to acetate

[Term]
id: GO:0045147
name: regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
synonym: "regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "regulation of initiation of acetate degradation by acetate" EXACT []
is_a: GO:0045734 ! regulation of acetate catabolic process
is_a: GO:1901457 ! regulation of response to acetate
relationship: regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045148
name: tripeptide aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide." [EC:3.4.11.4]
synonym: "alanine-phenylalanine-proline arylamidase activity" RELATED [EC:3.4.11.4]
synonym: "aminoexotripeptidase activity" RELATED [EC:3.4.11.4]
synonym: "aminotripeptidase activity" EXACT []
synonym: "imidoendopeptidase activity" RELATED [EC:3.4.11.4]
synonym: "lymphopeptidase activity" RELATED [EC:3.4.11.4]
synonym: "peptidase B" RELATED [EC:3.4.11.4]
synonym: "peptidase T" EXACT []
xref: EC:3.4.11.4
xref: MetaCyc:3.4.11.4-RXN
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0034701 ! tripeptidase activity

[Term]
id: GO:0045149
name: acetoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg]
synonym: "acetoin metabolism" EXACT []
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0045150
name: acetoin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]
synonym: "acetoin breakdown" EXACT []
synonym: "acetoin catabolism" EXACT []
synonym: "acetoin degradation" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0045149 ! acetoin metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0045151
name: acetoin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]
synonym: "acetoin anabolism" EXACT []
synonym: "acetoin biosynthesis" EXACT []
synonym: "acetoin formation" EXACT []
synonym: "acetoin synthesis" EXACT []
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0045149 ! acetoin metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0045152
name: antisigma factor binding
namespace: molecular_function
def: "Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg]
synonym: "antisigma factor antagonist activity" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045155
name: obsolete electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363]
comment: This term was obsoleted because it was not clearly defined, it has no corresponding EC or RHEA.
synonym: "cytochrome" RELATED []
synonym: "cytochrome c" NARROW []
is_obsolete: true

[Term]
id: GO:0045156
name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
synonym: "cytochrome bc1 complex" NARROW []
is_a: GO:0009055 ! electron transfer activity

[Term]
id: GO:0045157
name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
is_a: GO:0009055 ! electron transfer activity

[Term]
id: GO:0045158
name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
synonym: "cytochrome b/b6" RELATED []
synonym: "cytochrome b6" NARROW []
synonym: "cytochrome f" NARROW []
is_a: GO:0009055 ! electron transfer activity

[Term]
id: GO:0045159
name: myosin II binding
namespace: molecular_function
def: "Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, PMID:27697842]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0045160
name: myosin I complex
namespace: cellular_component
def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, PMID:9438839]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0045161
name: neuronal ion channel clustering
namespace: biological_process
def: "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0042551 ! neuron maturation

[Term]
id: GO:0045162
name: clustering of voltage-gated sodium channels
namespace: biological_process
def: "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440]
synonym: "clustering of voltage gated sodium channels" EXACT []
synonym: "clustering of voltage-dependent sodium channels" EXACT []
synonym: "Nav channel clustering" EXACT []
synonym: "voltage-gated sodium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0045163
name: clustering of voltage-gated potassium channels
namespace: biological_process
def: "The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440]
synonym: "clustering of voltage gated potassium channels" EXACT []
synonym: "clustering of voltage-dependent potassium channels" EXACT []
synonym: "Kv channel clustering" EXACT []
synonym: "voltage-gated potassium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0045164
name: obsolete secretin (sensu Mammalia)
namespace: molecular_function
def: "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551]
comment: This term was made obsolete because it represents a gene product rather than a molecular function.
synonym: "secretin (sensu Mammalia)" EXACT []
is_obsolete: true
consider: GO:0046659

[Term]
id: GO:0045165
name: cell fate commitment
namespace: biological_process
def: "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]
comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0045167
name: asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
synonym: "asymmetric protein localisation involved in cell fate determination" EXACT [GOC:mah]
synonym: "asymmetric protein localization involved in cell fate commitment" EXACT []
synonym: "asymmetric protein localization resulting in cell fate commitment" EXACT []
synonym: "cell fate commitment, asymmetric protein localization" EXACT []
is_a: GO:0008104 ! protein localization
relationship: part_of GO:0001709 ! cell fate determination

[Term]
id: GO:0045168
name: cell-cell signaling involved in cell fate commitment
namespace: biological_process
def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "cell fate commitment, cell-cell signaling" EXACT []
synonym: "cell fate commitment, cell-cell signalling" EXACT []
synonym: "cell-cell signaling during in cell fate commitment" EXACT []
synonym: "cell-cell signaling resulting in cell fate commitment" EXACT []
synonym: "cell-cell signalling during cell fate commitment" EXACT []
synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb]
synonym: "cell-cell signalling resulting in cell fate commitment" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0045169
name: fusome
namespace: cellular_component
def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0045170
name: spectrosome
namespace: cellular_component
def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf]
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0045171
name: intercellular bridge
namespace: cellular_component
def: "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0045172
name: germline ring canal
namespace: cellular_component
def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
is_a: GO:0045171 ! intercellular bridge

[Term]
id: GO:0045173
name: O-sialoglycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, PMID:8824323]
synonym: "O-sialoglycoprotein breakdown" EXACT []
synonym: "O-sialoglycoprotein catabolism" EXACT []
synonym: "O-sialoglycoprotein degradation" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process

[Term]
id: GO:0045174
name: glutathione dehydrogenase (ascorbate) activity
namespace: molecular_function
def: "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]
synonym: "dehydroascorbate reductase activity" EXACT []
synonym: "dehydroascorbic acid reductase activity" RELATED [EC:1.8.5.1]
synonym: "dehydroascorbic reductase activity" RELATED [EC:1.8.5.1]
synonym: "DHA reductase activity" RELATED [EC:1.8.5.1]
synonym: "GDOR" RELATED [EC:1.8.5.1]
synonym: "glutathione dehydroascorbate reductase activity" RELATED [EC:1.8.5.1]
synonym: "glutathione:dehydroascorbate oxidoreductase activity" RELATED [EC:1.8.5.1]
synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" RELATED [EC:1.8.5.1]
xref: EC:1.8.5.1
xref: KEGG_REACTION:R01108
xref: MetaCyc:1.8.5.1-RXN
xref: Reactome:R-HSA-198813 "GSTO dimers reduce DeHA to AscH-"
xref: RHEA:24424
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0045175
name: basal protein localization
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
synonym: "basal protein localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of basal protein localization" EXACT []
synonym: "establishment and maintenance of protein localization in basal part of cell" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0045176
name: apical protein localization
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
synonym: "apical protein localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of apical protein localization" EXACT []
synonym: "establishment and maintenance of protein localization in apical part of cell" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0045177
name: apical part of cell
namespace: cellular_component
def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
synonym: "apical region of cell" EXACT [GOC:krc]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0045178
name: basal part of cell
namespace: cellular_component
def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0045179
name: apical cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0045180
name: basal cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf]
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0045181
name: obsolete glutamate synthase activity, NAD(P)H as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [GOC:curators]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "glutamate synthase activity, NADH or NADPH as acceptor" RELATED []
is_obsolete: true
consider: GO:0004355
consider: GO:0016040

[Term]
id: GO:0045182
name: translation regulator activity
namespace: molecular_function
def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "translation factor activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045183
name: translation factor activity, non-nucleic acid binding
namespace: molecular_function
def: "A translation regulator activity that does not involve binding to nucleic acids." [GOC:ai, GOC:dph, GOC:tb]
is_a: GO:0045182 ! translation regulator activity

[Term]
id: GO:0045184
name: establishment of protein localization
namespace: biological_process
def: "The directed movement of a protein to a specific location." [GOC:bf]
synonym: "establishment of protein localisation" EXACT [GOC:mah]
synonym: "protein positioning" EXACT []
synonym: "protein recruitment" EXACT []
is_a: GO:0008104 ! protein localization
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0045185
name: maintenance of protein location
namespace: biological_process
def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
synonym: "active protein retrieval" NARROW []
synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb]
synonym: "protein retention" NARROW []
synonym: "protein sequestering" NARROW []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0008104 ! protein localization

[Term]
id: GO:0045186
name: zonula adherens assembly
namespace: biological_process
def: "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
is_a: GO:0034333 ! adherens junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0045187
name: regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
synonym: "regulation of sleep" EXACT []
is_a: GO:0042749 ! regulation of circadian sleep/wake cycle
relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0045188
name: regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators]
synonym: "regulation of non-REM sleep" EXACT []
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0045189
name: obsolete connective tissue growth factor biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [GOC:curators]
comment: This term was obsoleted because it represent translation of a gene product, not a specific process.
synonym: "connective tissue growth factor anabolism" EXACT []
synonym: "connective tissue growth factor biosynthesis" EXACT []
synonym: "connective tissue growth factor formation" EXACT []
synonym: "connective tissue growth factor synthesis" EXACT []
synonym: "CTGF biosynthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045190
name: isotype switching
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149]
comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
synonym: "class switch recombination" EXACT []
synonym: "class switching" EXACT []
synonym: "isotype switch recombination" EXACT []
xref: Wikipedia:Immunoglobulin_class_switching
is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response
is_a: GO:0002312 ! B cell activation involved in immune response

[Term]
id: GO:0045191
name: regulation of isotype switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai]
synonym: "regulation of class switch recombination" EXACT []
synonym: "regulation of class switching" EXACT []
synonym: "regulation of isotype switch recombination" EXACT []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0050864 ! regulation of B cell activation
relationship: regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045192
name: obsolete low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "LDL catabolic process" EXACT []
synonym: "LDL catabolism" EXACT []
synonym: "low-density lipoprotein breakdown" EXACT []
synonym: "low-density lipoprotein catabolic process" EXACT []
synonym: "low-density lipoprotein catabolism" EXACT []
synonym: "low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045193
name: obsolete acetylated low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "Ac-LDL catabolic process" EXACT []
synonym: "Ac-LDL catabolism" EXACT []
synonym: "acetylated low-density lipoprotein breakdown" EXACT []
synonym: "acetylated low-density lipoprotein catabolic process" EXACT []
synonym: "acetylated low-density lipoprotein catabolism" EXACT []
synonym: "acetylated low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045194
name: obsolete oxidized low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "Ox-LDL catabolic process" EXACT []
synonym: "Ox-LDL catabolism" EXACT []
synonym: "oxidized low-density lipoprotein breakdown" EXACT []
synonym: "oxidized low-density lipoprotein catabolic process" EXACT []
synonym: "oxidized low-density lipoprotein catabolism" EXACT []
synonym: "oxidized low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045195
name: obsolete gallstone formation
namespace: biological_process
def: "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm]
comment: This term was made obsolete because the process it represents is pathological.
synonym: "gallstone formation" EXACT []
is_obsolete: true

[Term]
id: GO:0045196
name: establishment or maintenance of neuroblast polarity
namespace: biological_process
alt_id: GO:0043339
alt_id: GO:0043342
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]
synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0055059 ! asymmetric neuroblast division

[Term]
id: GO:0045197
name: establishment or maintenance of epithelial cell apical/basal polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity

[Term]
id: GO:0045198
name: establishment of epithelial cell apical/basal polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0030859 ! polarized epithelial cell differentiation
is_a: GO:0035089 ! establishment of apical/basal cell polarity
is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity
is_a: GO:0090162 ! establishment of epithelial cell polarity

[Term]
id: GO:0045199
name: maintenance of epithelial cell apical/basal polarity
namespace: biological_process
def: "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf]
is_a: GO:0035090 ! maintenance of apical/basal cell polarity
is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity

[Term]
id: GO:0045200
name: establishment of neuroblast polarity
namespace: biological_process
alt_id: GO:0043340
alt_id: GO:0043343
def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "establishment of neuroblast cell polarity" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity

[Term]
id: GO:0045201
name: maintenance of neuroblast polarity
namespace: biological_process
alt_id: GO:0043341
alt_id: GO:0043344
def: "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0030011 ! maintenance of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_synapse
synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124]
synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497]
synonym: "synaptic junction" EXACT []
xref: NIF_Subcellular:sao914572699
xref: Wikipedia:Chemical_synapse
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0045203
name: obsolete integral component of cell outer membrane
namespace: cellular_component
def: "OBSOLETE. The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators, GOC:mtg_sensu]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to cell outer membrane" NARROW []
synonym: "integral to external membrane" RELATED []
synonym: "integral to outer membrane" RELATED []
is_obsolete: true
replaced_by: GO:0009279

[Term]
id: GO:0045204
name: obsolete MAPK export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:ebc]
comment: The reason for obsoletion is that this term represents a specific substrate, out of scope for GO.
synonym: "cytoplasmic translocation of MAP kinase" EXACT []
synonym: "cytoplasmic translocation of mitogen-activated protein kinase" EXACT []
synonym: "MAPK export from cell nucleus" EXACT []
synonym: "MAPK export out of nucleus" EXACT []
synonym: "MAPK transport from nucleus to cytoplasm" EXACT []
synonym: "MAPK-nucleus export" EXACT []
is_obsolete: true

[Term]
id: GO:0045205
name: obsolete MAPK transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because we do not know what it was intended to represent when it was created.
synonym: "MAPK transporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0045206
name: obsolete MAPK phosphatase transporter activity
namespace: molecular_function
alt_id: GO:0045207
def: "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because we do not know what it was intended to represent when it was created.
synonym: "leptomycin B-sensitive MAPK phosphatase transporter activity" NARROW []
synonym: "leptomycin B-sensitive MKP shuttle" NARROW []
synonym: "MAPK phosphatase transporter activity" EXACT []
synonym: "MKP shuttle" NARROW []
is_obsolete: true

[Term]
id: GO:0045208
name: obsolete MAPK phosphatase export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc]
comment: The reason for obsoletion is that this term represents a specific substrate, out of scope for GO.
synonym: "MAPK phosphatase export from cell nucleus" EXACT []
synonym: "MAPK phosphatase export out of nucleus" EXACT []
synonym: "MAPK phosphatase transport from nucleus to cytoplasm" EXACT []
synonym: "MAPK phosphatase-nucleus export" EXACT []
is_obsolete: true

[Term]
id: GO:0045209
name: obsolete MAPK phosphatase export from nucleus, leptomycin B sensitive
namespace: biological_process
def: "OBSOLETE. Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc]
comment: The reason for obsoletion is that this term represents a specific substrate, out of scope for GO.
synonym: "leptomycin B-sensitive MAPK phosphatase export out of nucleus" EXACT []
synonym: "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm" EXACT []
synonym: "leptomycin B-sensitive MAPK phosphatase-nucleus export" EXACT []
synonym: "MAPK phosphatase export from cell nucleus, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase export out of nucleus, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase-nucleus export, leptomycin B sensitive" EXACT []
is_obsolete: true

[Term]
id: GO:0045210
name: FasL biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [https://en.wikipedia.org/wiki/Fas_ligand, PMID:10637433]
synonym: "APT1LG1 biosynthetic process" EXACT [GOC:add]
synonym: "CD178 biosynthetic process" EXACT [GOC:add]
synonym: "CD95L biosynthesis" EXACT [GOC:add]
synonym: "CD95L biosynthetic process" EXACT [GOC:add]
synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PR:000000095]
synonym: "Fas-L biosynthetic process" EXACT [GOC:add]
synonym: "FasL anabolism" EXACT []
synonym: "FasL biosynthesis" EXACT []
synonym: "FasL formation" EXACT []
synonym: "FasL synthesis" EXACT []
synonym: "FASLG biosynthetic process" EXACT [GOC:add]
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0045211
name: postsynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
subset: goslim_synapse
synonym: "post-synaptic membrane" EXACT []
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0045212
name: obsolete neurotransmitter receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "neurotransmitter receptor anabolism" EXACT []
synonym: "neurotransmitter receptor biosynthesis" EXACT []
synonym: "neurotransmitter receptor formation" EXACT []
synonym: "neurotransmitter receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045213
name: obsolete neurotransmitter receptor metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators]
comment: The reason for obsoletion is that 'neurotransmitter' is unnecessary grouping in the metabolism branch of the ontology, and it creates true path violations.
synonym: "neurotransmitter receptor metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0045214
name: sarcomere organization
namespace: biological_process
alt_id: GO:0006938
def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
synonym: "sarcomere alignment" EXACT []
synonym: "sarcomere organisation" EXACT []
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0045216
name: cell-cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "cell-cell junction assembly and maintenance" EXACT []
synonym: "cell-cell junction biogenesis" RELATED []
synonym: "cell-cell junction organisation" EXACT [GOC:mah]
synonym: "intercellular junction assembly and maintenance" EXACT []
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0045217
name: cell-cell junction maintenance
namespace: biological_process
def: "The maintenance of junctions between cells." [GOC:ai]
synonym: "intercellular junction maintenance" EXACT []
is_a: GO:0034331 ! cell junction maintenance
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0045218
name: zonula adherens maintenance
namespace: biological_process
def: "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf]
is_a: GO:0034334 ! adherens junction maintenance

[Term]
id: GO:0045219
name: regulation of FasL production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "regulation of FasL anabolism" EXACT []
synonym: "regulation of FasL biosynthesis" EXACT []
synonym: "regulation of FasL formation" EXACT []
synonym: "regulation of FasL synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045220
name: positive regulation of FasL production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "activation of FasL biosynthetic process" NARROW []
synonym: "positive regulation of FasL anabolism" EXACT []
synonym: "positive regulation of FasL biosynthesis" EXACT []
synonym: "positive regulation of FasL biosynthetic process" EXACT []
synonym: "positive regulation of FasL formation" EXACT []
synonym: "positive regulation of FasL synthesis" EXACT []
synonym: "stimulation of FasL biosynthetic process" NARROW []
synonym: "up regulation of FasL biosynthetic process" EXACT []
synonym: "up-regulation of FasL biosynthetic process" EXACT []
synonym: "upregulation of FasL biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0045219 ! regulation of FasL production
relationship: positively_regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045221
name: negative regulation of FasL production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "down regulation of FasL biosynthetic process" EXACT []
synonym: "down-regulation of FasL biosynthetic process" EXACT []
synonym: "downregulation of FasL biosynthetic process" EXACT []
synonym: "inhibition of FasL biosynthetic process" NARROW []
synonym: "negative regulation of FasL anabolism" EXACT []
synonym: "negative regulation of FasL biosynthesis" EXACT []
synonym: "negative regulation of FasL biosynthetic process" EXACT []
synonym: "negative regulation of FasL formation" EXACT []
synonym: "negative regulation of FasL synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0045219 ! regulation of FasL production
relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045222
name: CD4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732]
synonym: "CD4 anabolism" EXACT []
synonym: "CD4 biosynthesis" EXACT []
synonym: "CD4 formation" EXACT []
synonym: "CD4 synthesis" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0045223
name: regulation of CD4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "regulation of CD4 anabolism" EXACT []
synonym: "regulation of CD4 biosynthesis" EXACT []
synonym: "regulation of CD4 biosynthetic process" EXACT []
synonym: "regulation of CD4 formation" EXACT []
synonym: "regulation of CD4 synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045224
name: positive regulation of CD4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "activation of CD4 biosynthetic process" NARROW []
synonym: "positive regulation of CD4 anabolism" EXACT []
synonym: "positive regulation of CD4 biosynthesis" EXACT []
synonym: "positive regulation of CD4 biosynthetic process" EXACT []
synonym: "positive regulation of CD4 formation" EXACT []
synonym: "positive regulation of CD4 synthesis" EXACT []
synonym: "stimulation of CD4 biosynthetic process" NARROW []
synonym: "up regulation of CD4 biosynthetic process" EXACT []
synonym: "up-regulation of CD4 biosynthetic process" EXACT []
synonym: "upregulation of CD4 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 production
relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045225
name: negative regulation of CD4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "down regulation of CD4 biosynthetic process" EXACT []
synonym: "down-regulation of CD4 biosynthetic process" EXACT []
synonym: "downregulation of CD4 biosynthetic process" EXACT []
synonym: "inhibition of CD4 biosynthetic process" NARROW []
synonym: "negative regulation of CD4 anabolism" EXACT []
synonym: "negative regulation of CD4 biosynthesis" EXACT []
synonym: "negative regulation of CD4 biosynthetic process" EXACT []
synonym: "negative regulation of CD4 formation" EXACT []
synonym: "negative regulation of CD4 synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 production
relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045226
name: obsolete extracellular polysaccharide biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]
comment: The reason for obsoletion is that this term is now redundant with GO:0000271, polysaccharide biosynthetic process
synonym: "extracellular polysaccharide anabolism" EXACT []
synonym: "extracellular polysaccharide biosynthesis" EXACT []
synonym: "extracellular polysaccharide formation" EXACT []
synonym: "extracellular polysaccharide synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0000271

[Term]
id: GO:0045227
name: capsule polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators]
synonym: "capsular polysaccharide biosynthesis" EXACT []
synonym: "capsular polysaccharide biosynthetic process" EXACT []
synonym: "capsule polysaccharide anabolism" EXACT []
synonym: "capsule polysaccharide biosynthesis" EXACT []
synonym: "capsule polysaccharide formation" EXACT []
synonym: "capsule polysaccharide synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0045230 ! capsule organization

[Term]
id: GO:0045228
name: slime layer polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators]
synonym: "slime layer polysaccharide anabolism" EXACT []
synonym: "slime layer polysaccharide biosynthesis" EXACT []
synonym: "slime layer polysaccharide formation" EXACT []
synonym: "slime layer polysaccharide synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0045231 ! slime layer organization

[Term]
id: GO:0045229
name: external encapsulating structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "external encapsulating structure organisation" EXACT []
synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0045230
name: capsule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]
subset: goslim_pir
synonym: "capsule organisation" EXACT []
synonym: "capsule organization and biogenesis" RELATED []
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045231
name: slime layer organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai]
subset: goslim_pir
synonym: "slime layer organisation" EXACT []
synonym: "slime layer organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045232
name: S-layer organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai]
synonym: "S-layer organisation" EXACT []
synonym: "S-layer organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045233
name: obsolete natural killer cell receptor activity
namespace: molecular_function
def: "OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc]
comment: This term was made obsolete because the receptor is defined based on its cellular expression pattern, and the definition is inaccurate: receptors on natural killer cells can either activate or inhibit natural killer (NK) cell-mediated cytotoxicity.
synonym: "Ly49i" NARROW []
synonym: "natural killer cell receptor activity" EXACT []
synonym: "NK cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0002769
consider: GO:0004888
consider: GO:0030101

[Term]
id: GO:0045234
name: protein palmitoleylation
namespace: biological_process
alt_id: GO:0045235
def: "The covalent attachment of a palmitoleyl group to a protein." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid palmitoleylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0045236
name: CXCR chemokine receptor binding
namespace: molecular_function
def: "Binding to a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892]
synonym: "alpha chemokine receptor binding" EXACT []
synonym: "alpha chemokine receptor ligand" NARROW []
synonym: "C-X-C chemokine receptor ligand" NARROW []
synonym: "CXC chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0045237
name: CXCR1 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892]
synonym: "CXCR1 chemokine receptor ligand" NARROW []
is_a: GO:0005153 ! interleukin-8 receptor binding

[Term]
id: GO:0045238
name: CXCR2 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892]
synonym: "CXCR2 chemokine receptor ligand" NARROW []
is_a: GO:0005153 ! interleukin-8 receptor binding

[Term]
id: GO:0045239
name: tricarboxylic acid cycle heteromeric enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "TCA cycle enzyme complex" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0045240
name: alpha-ketoacid dehydrogenase complex
namespace: cellular_component
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present." [GOC:mah, PMID:10745006]
synonym: "2-oxoacid dehydrogenase complex" EXACT []
synonym: "dihydrolipoyl dehydrogenase complex" EXACT []
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045241
name: obsolete cytosolic alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu]
comment: The reason for obsoletion is that this term is equivalent to cytosolic oxoglutarate dehydrogenase complex.
synonym: "2-oxoglutarate dehydrogenase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045252

[Term]
id: GO:0045242
name: isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah]
is_a: GO:0045239 ! tricarboxylic acid cycle heteromeric enzyme complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045243
name: obsolete cytosolic isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "OBSOLETE. Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu]
comment: The reason for obsoletion is that this term is unnecessarily taxon-specific.
synonym: "isocitrate dehydrogenase complex (NAD+)" BROAD []
is_obsolete: true
replaced_by: GO:0045242

[Term]
id: GO:0045244
name: succinate-CoA ligase complex (GDP-forming)
namespace: cellular_component
alt_id: GO:0008325
alt_id: GO:0045245
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [GOC:jl, PMID:27487822]
synonym: "succinyl-CoA synthetase, GDP-forming" EXACT [CORUM:392]
is_a: GO:0042709 ! succinate-CoA ligase complex

[Term]
id: GO:0045246
name: obsolete cytosolic tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "OBSOLETE. Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]
comment: The reason for obsoletion is that this term is unnecessarily taxon-specific.
synonym: "TCA cycle enzyme complex" BROAD []
synonym: "tricarboxylic acid cycle enzyme complex" BROAD []
is_obsolete: true
replaced_by: GO:0045239

[Term]
id: GO:0045247
name: cytosolic electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732]
is_a: GO:0045251 ! electron transfer flavoprotein complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0045248
name: obsolete cytosolic oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, PMID:10848975]
comment: This term is unnecessarily taxon-specific.
is_obsolete: true
replaced_by: GO:0045252

[Term]
id: GO:0045249
name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, PMID:9395502]
comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0045250
name: obsolete cytosolic pyruvate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A cytosolic complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094]
comment: This term is unnecessarily taxon-specific.
synonym: "pyruvate dehydrogenase complex (lipoamide)" RELATED []
is_obsolete: true
replaced_by: GO:0045254

[Term]
id: GO:0045251
name: electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex facilitating the electron transfer from an acyl-CoA molecule to ubiquinone via its flavin adenine dinucleotide (FAD) cofactor. Usually contains an alpha and a beta subunit and the structural cofactor adenosine monophosphate (AMP). Part of a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the electron transport system." [GOC:bhm, ISBN:0198506732]
subset: goslim_pir
synonym: "ETF complex" EXACT [GOC:bhm]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0045252
name: oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:10672230]
comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.
subset: goslim_pir
synonym: "alpha-ketoglutarate dehydrogenase complex" EXACT []
synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT []
synonym: "KGDHC" EXACT []
xref: Wikipedia:Oxoglutarate_dehydrogenase_complex
is_a: GO:0045239 ! tricarboxylic acid cycle heteromeric enzyme complex
is_a: GO:0045240 ! alpha-ketoacid dehydrogenase complex

[Term]
id: GO:0045253
name: pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502]
comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
subset: goslim_pir
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0045254
name: pyruvate dehydrogenase complex
namespace: cellular_component
alt_id: GO:0009364
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:36863425]
comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (acetyl-transferring) activity ; GO:0004739' (E1), 'dihydrolipoyllysine-residue acetyltransferase activity ; GO:0004742' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'pyruvate dehydrogenase (NAD+) activity ; GO:0034604'.
subset: goslim_pir
synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT []
xref: Wikipedia:Pyruvate_dehydrogenase_complex
is_a: GO:0045240 ! alpha-ketoacid dehydrogenase complex

[Term]
id: GO:0045257
name: obsolete succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "OBSOLETE. The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045273

[Term]
id: GO:0045258
name: obsolete plasma membrane succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "OBSOLETE. The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045273

[Term]
id: GO:0045259
name: proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0045255
def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663]
synonym: "F1-F0 complex" EXACT []
synonym: "hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "hydrogen-transporting ATP synthase complex" EXACT []
synonym: "proton-transporting F-type ATPase complex" RELATED []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
is_a: GO:0034703 ! cation channel complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0045260
name: obsolete plasma membrane proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0045256
def: "OBSOLETE. A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "hydrogen-translocating F-type ATPase complex" BROAD []
synonym: "hydrogen-transporting ATP synthase" EXACT []
synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "proton-transporting ATP synthase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045259

[Term]
id: GO:0045261
name: proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]
synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT []
is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045262
name: obsolete plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "OBSOLETE. The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, PMID:10838056]
comment: See also the cellular component term 'plasma membrane ; GO:0005886'.\nThe reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD []
is_obsolete: true
replaced_by: GO:0045261

[Term]
id: GO:0045263
name: proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]
synonym: "hydrogen-transporting ATP synthase complex, coupling factor F(o)" EXACT [GOC:mah]
synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW []
synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT []
synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT []
is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045264
name: obsolete plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "OBSOLETE. All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" BROAD []
synonym: "proton-transporting ATP synthase complex, coupling factor F(o)" BROAD []
is_obsolete: true
replaced_by: GO:0045263

[Term]
id: GO:0045265
name: proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056]
synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0045266
name: obsolete plasma membrane proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "OBSOLETE. One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "hydrogen-transporting ATP synthase, stator stalk" BROAD []
synonym: "proton-transporting ATP synthase, stator stalk" BROAD []
is_obsolete: true
replaced_by: GO:0045265

[Term]
id: GO:0045267
name: proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056]
synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045268
name: obsolete plasma membrane proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "OBSOLETE. The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "hydrogen-transporting ATP synthase, catalytic core" BROAD []
synonym: "proton-transporting ATP synthase, catalytic core" BROAD []
is_obsolete: true
replaced_by: GO:0045267

[Term]
id: GO:0045269
name: proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056]
synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045270
name: obsolete plasma membrane proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "OBSOLETE. One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "hydrogen-transporting ATP synthase, central stalk" BROAD []
synonym: "proton-transporting ATP synthase, central stalk" BROAD []
is_obsolete: true
replaced_by: GO:0045269

[Term]
id: GO:0045271
name: respiratory chain complex I
namespace: cellular_component
alt_id: GO:0045279
def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:imk, GOC:jid, ISBN:0716749556]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'.
synonym: "electron transport complex I" RELATED []
synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT []
synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT []
synonym: "NADH-Q oxidoreductase complex" EXACT []
is_a: GO:0030964 ! NADH dehydrogenase complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:0045272
name: obsolete plasma membrane respiratory chain complex I
namespace: cellular_component
def: "OBSOLETE. A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "NADH dehydrogenase (ubiquinone) complex" BROAD []
synonym: "respiratory chain complex I" BROAD []
is_obsolete: true
replaced_by: GO:0045271

[Term]
id: GO:0045273
name: respiratory chain complex II (succinate dehydrogenase)
namespace: cellular_component
def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684]
subset: goslim_pir
synonym: "electron transport complex II" RELATED []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045274
name: obsolete plasma membrane respiratory chain complex II
namespace: cellular_component
def: "OBSOLETE. A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "respiratory chain complex II" BROAD []
is_obsolete: true
replaced_by: GO:0045273

[Term]
id: GO:0045275
name: respiratory chain complex III
namespace: cellular_component
alt_id: GO:0032842
alt_id: GO:0045285
def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733]
subset: goslim_pir
synonym: "coenzyme Q-cytochrome c oxidoreductase complex" RELATED []
synonym: "coenzyme Q-cytochrome c reductase complex" RELATED []
synonym: "complex III" EXACT []
synonym: "CoQH2-cytochrome c reductase complex" RELATED []
synonym: "cytochrome bc(1) complex" EXACT []
synonym: "cytochrome bc1 complex" EXACT []
synonym: "electron transport complex III" RELATED []
synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT []
synonym: "ubiquinol-cytochrome-c reductase complex" EXACT []
xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase
is_a: GO:0070069 ! cytochrome complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902495 ! transmembrane transporter complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045276
name: obsolete plasma membrane respiratory chain complex III
namespace: cellular_component
alt_id: GO:0045286
def: "OBSOLETE. A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "plasma membrane coenzyme Q-cytochrome c oxidoreductase complex" EXACT []
synonym: "plasma membrane coenzyme Q-cytochrome c reductase complex" EXACT []
synonym: "plasma membrane cytochrome bc1 complex" EXACT []
synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT []
synonym: "respiratory chain complex III" BROAD []
synonym: "ubiquinol-cytochrome c oxidoreductase complex" BROAD []
synonym: "ubiquinol-cytochrome-c reductase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045275

[Term]
id: GO:0045277
name: respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045287
def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]
subset: goslim_pir
synonym: "cytochrome c oxidase complex" EXACT []
synonym: "electron transport complex IV" RELATED []
is_a: GO:0070069 ! cytochrome complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902495 ! transmembrane transporter complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045278
name: obsolete plasma membrane respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045288
def: "OBSOLETE. A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "cytochrome c oxidase complex" BROAD []
synonym: "respiratory chain complex IV" BROAD []
is_obsolete: true
replaced_by: GO:0045277

[Term]
id: GO:0045281
name: obsolete succinate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
is_obsolete: true
replaced_by: GO:0045273

[Term]
id: GO:0045282
name: obsolete plasma membrane succinate dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "succinate dehydrogenase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045273

[Term]
id: GO:0045283
name: fumarate reductase complex
namespace: cellular_component
def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0045284
name: obsolete plasma membrane fumarate reductase complex
namespace: cellular_component
def: "OBSOLETE. A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.\nThe reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "fumarate reductase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045283

[Term]
id: GO:0045289
name: luciferin monooxygenase activity
namespace: molecular_function
def: "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf]
synonym: "luciferase activity" EXACT []
synonym: "luciferase monooxygenase activity" RELATED []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0045290
name: D-arabinose 1-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+." [EC:1.1.1.117]
synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" RELATED [EC:1.1.1.117]
xref: EC:1.1.1.117
xref: MetaCyc:1.1.1.117-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045291
name: mRNA trans splicing, SL addition
namespace: biological_process
def: "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423]
synonym: "nuclear mRNA trans splicing, SL addition" EXACT [GOC:vw]
synonym: "nuclear mRNA trans splicing, spliced leader addition" EXACT []
is_a: GO:0000365 ! mRNA trans splicing, via spliceosome

[Term]
id: GO:0045292
name: mRNA cis splicing, via spliceosome
namespace: biological_process
def: "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]
synonym: "nuclear mRNA cis splicing, via spliceosome" EXACT [GOC:vw]
synonym: "nuclear mRNA cis splicing, via U2-type spliceosome" NARROW []
synonym: "splicing" BROAD [GOC:vw]
is_a: GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0045293
name: mRNA editing complex
namespace: cellular_component
def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [PMID:11564867, PMID:12139607, PMID:24316715]
subset: goslim_pir
synonym: "editosome" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0045294
name: alpha-catenin binding
namespace: molecular_function
def: "Binding to catenin complex alpha subunit." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045295
name: gamma-catenin binding
namespace: molecular_function
def: "Binding to catenin complex gamma subunit." [GOC:bf]
synonym: "plakoglobin binding" EXACT [GOC:BHF]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045296
name: cadherin binding
namespace: molecular_function
def: "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]
is_a: GO:0050839 ! cell adhesion molecule binding

[Term]
id: GO:0045297
name: obsolete post-mating behavior
namespace: biological_process
def: "OBSOLETE. The specific behavior of an organism following mating." [GOC:bf, GOC:pr]
comment: This term was obsoleted because it was not precisely defined.
synonym: "post-mating behaviour" EXACT []
is_obsolete: true

[Term]
id: GO:0045298
name: tubulin complex
namespace: cellular_component
def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [ISBN:0716731363]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0045299
name: otolith mineralization
namespace: biological_process
def: "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873]
is_a: GO:0031214 ! biomineral tissue development
relationship: part_of GO:0048840 ! otolith development

[Term]
id: GO:0045300
name: stearoyl-[ACP] desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [RHEA:11776]
synonym: "acyl-[acyl-carrier-protein] desaturase activity" RELATED []
synonym: "acyl-acyl-carrier-protein desaturase activity" RELATED [EC:1.14.19.2]
synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" RELATED [EC:1.14.19.2]
synonym: "stearyl acyl carrier protein desaturase activity" RELATED [EC:1.14.19.2]
synonym: "stearyl-ACP desaturase activity" RELATED [EC:1.14.19.2]
xref: EC:1.14.19.2
xref: KEGG_REACTION:R03370
xref: MetaCyc:RXN-7903
xref: RHEA:11776
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0045301
name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666]
synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT []
synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT []
synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0045302
name: choloylglycine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" RELATED [EC:3.5.1.24]
synonym: "bile salt hydrolase activity" RELATED [EC:3.5.1.24]
synonym: "choloyltaurine hydrolase activity" RELATED [EC:3.5.1.24]
synonym: "glycocholase activity" RELATED [EC:3.5.1.24]
xref: EC:3.5.1.24
xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN
xref: RHEA:19353
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0045303
name: diaminobutyrate-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate." [EC:2.6.1.76, RHEA:11160]
synonym: "2,4-diaminobutyrate 4-aminotransferase activity" RELATED [EC:2.6.1.76]
synonym: "DAB aminotransferase activity" RELATED [EC:2.6.1.76]
synonym: "DABA aminotransferase activity" RELATED [EC:2.6.1.76]
synonym: "diaminibutyric acid aminotransferase activity" RELATED [EC:2.6.1.76]
synonym: "diaminobutyrate transaminase activity" RELATED [EC:2.6.1.76]
synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.76]
synonym: "EctB" RELATED [EC:2.6.1.76]
synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" RELATED [EC:2.6.1.76]
synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" RELATED [EC:2.6.1.76]
synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" RELATED [EC:2.6.1.76]
xref: EC:2.6.1.76
xref: KEGG_REACTION:R06977
xref: MetaCyc:R101-RXN
xref: RHEA:11160
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0045304
name: regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg]
synonym: "regulator of establishment of competence for transformation activity" RELATED []
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045305
name: obsolete regulator of establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
synonym: "regulator of establishment of competence for transformation activity" EXACT []
is_obsolete: true
replaced_by: GO:0045304

[Term]
id: GO:0045306
name: obsolete inhibitor of the establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
synonym: "inhibitor of the establishment of competence for transformation activity" EXACT []
is_obsolete: true
replaced_by: GO:0045808

[Term]
id: GO:0045307
name: obsolete activator of the establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Activates the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
synonym: "activator of the establishment of competence for transformation activity" EXACT []
is_obsolete: true
replaced_by: GO:0045809

[Term]
id: GO:0045309
name: protein phosphorylated amino acid binding
namespace: molecular_function
def: "Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators]
synonym: "phosphoprotein amino acid binding" RELATED []
is_a: GO:0051219 ! phosphoprotein binding

[Term]
id: GO:0045310
name: obsolete phosphoserine/phosphothreonine binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators]
comment: This term was made obsolete because it represents two functions.
synonym: "phosphoserine/phosphothreonine binding" EXACT []
is_obsolete: true
consider: GO:0050815
consider: GO:0050816

[Term]
id: GO:0045311
name: invasive growth in response to pheromone
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai, GOC:dph, GOC:mcc]
is_a: GO:0036267 ! invasive filamentous growth
relationship: part_of GO:0019236 ! response to pheromone

[Term]
id: GO:0045312
name: nor-spermidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators]
synonym: "nor-spermidine anabolism" EXACT []
synonym: "nor-spermidine biosynthesis" EXACT []
synonym: "nor-spermidine formation" EXACT []
synonym: "nor-spermidine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0046204 ! nor-spermidine metabolic process

[Term]
id: GO:0045313
name: rhabdomere membrane biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl]
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0042052 ! rhabdomere development

[Term]
id: GO:0045314
name: regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "regulation of eye photoreceptor development" BROAD []
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
relationship: part_of GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045315
name: positive regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "activation of eye photoreceptor development" BROAD []
synonym: "positive regulation of eye photoreceptor development" BROAD []
synonym: "stimulation of eye photoreceptor development" BROAD []
synonym: "up regulation of eye photoreceptor development" BROAD []
synonym: "up-regulation of eye photoreceptor development" BROAD []
synonym: "upregulation of eye photoreceptor development" BROAD []
is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development
is_a: GO:0045314 ! regulation of compound eye photoreceptor development
relationship: positively_regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045316
name: negative regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "down regulation of eye photoreceptor development" BROAD []
synonym: "down-regulation of eye photoreceptor development" BROAD []
synonym: "downregulation of eye photoreceptor development" BROAD []
synonym: "inhibition of eye photoreceptor development" BROAD []
synonym: "negative regulation of eye photoreceptor development" BROAD []
is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development
is_a: GO:0045314 ! regulation of compound eye photoreceptor development
relationship: negatively_regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045317
name: equator specification
namespace: biological_process
def: "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity

[Term]
id: GO:0045319
name: obsolete SRP-independent cotranslational protein-membrane targeting, translocation
namespace: biological_process
def: "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "SRP-independent cotranslational membrane targeting, translocation" EXACT []
synonym: "SRP-independent cotranslational protein-membrane targeting, translocation" EXACT []
is_obsolete: true

[Term]
id: GO:0045320
name: obsolete chloroplast proton-transporting ATP synthase complex
namespace: cellular_component
def: "OBSOLETE. A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT []
synonym: "hydrogen-translocating F-type ATPase complex" BROAD []
is_obsolete: true
replaced_by: GO:0045259

[Term]
id: GO:0045321
name: leukocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]
synonym: "immune cell activation" EXACT []
synonym: "leucocyte activation" EXACT []
xref: Wikipedia:Immunologic_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0045322
name: unmethylated CpG binding
namespace: molecular_function
def: "Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0045323
name: interleukin-1 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075]
synonym: "IL-1 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0045324
name: late endosome to vacuole transport
namespace: biological_process
def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0045325
name: obsolete peptidyl-tryptophan hydroxylation
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan." [RESID:AA0322]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0045326
name: obsolete protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323]
comment: The reason for obsoletion is that is not known to be catalyzed by any gene product.
synonym: "DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0045327
name: obsolete protein-DNA covalent cross-linking via peptidyl-tyrosine
namespace: biological_process
def: "OBSOLETE. The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue." [GOC:jsg]
comment: The reason for obsoletion is that is not known to be catalyzed by any gene product.
synonym: "DNA-protein covalent cross-linking via peptidyl-tyrosine" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0045328
name: obsolete cytochrome P450 4A1-heme linkage
namespace: biological_process
def: "OBSOLETE. The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [GOC:cjm, RESID:AA0324]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cytochrome P450 4A1-haem linkage" EXACT []
is_obsolete: true

[Term]
id: GO:0045329
name: carnitine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
synonym: "carnitine anabolism" EXACT []
synonym: "carnitine biosynthesis" EXACT []
synonym: "carnitine formation" EXACT []
synonym: "carnitine synthesis" EXACT []
synonym: "vitamin Bt biosynthesis" EXACT []
synonym: "vitamin Bt biosynthetic process" EXACT []
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0009437 ! carnitine metabolic process

[Term]
id: GO:0045330
name: obsolete aspartyl esterase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, UniProtKB-KW:KW-0063]
comment: This term was obsoleted because it does not correspond to a precise activity.
is_obsolete: true
consider: GO:0030599

[Term]
id: GO:0045331
name: obsolete coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2]
comment: This term was made obsolete because it represents two activities.
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" EXACT []
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity" EXACT []
synonym: "heterodisulfide reductase activity" EXACT []
is_obsolete: true
consider: GO:0051911
consider: GO:0051912

[Term]
id: GO:0045332
name: phospholipid translocation
namespace: biological_process
def: "The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]
comment: Note that this term describes the transbilayer motion of individual phospholipid molecules, and should not be confused with 'phospholipid scrambling ; GO:0017121'.
synonym: "flippase" RELATED []
synonym: "phospholipid scrambling" RELATED []
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0034204 ! lipid translocation

[Term]
id: GO:0045333
name: cellular respiration
namespace: biological_process
def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
synonym: "oxidative metabolic process" EXACT []
synonym: "oxidative metabolism" EXACT []
synonym: "respiration" BROAD []
xref: Wikipedia:Cellular_respiration
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0045334
name: clathrin-coated endocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]
xref: NIF_Subcellular:sao1243595998
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045335
name: phagocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
synonym: "phagosome" EXACT []
xref: Wikipedia:Phagosome
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045336
name: clathrin-coated phagocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
synonym: "clathrin-coated phagosome" EXACT []
is_a: GO:0045334 ! clathrin-coated endocytic vesicle
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0045337
name: farnesyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl]
synonym: "farnesyl diphosphate anabolism" EXACT []
synonym: "farnesyl diphosphate biosynthesis" EXACT []
synonym: "farnesyl diphosphate formation" EXACT []
synonym: "farnesyl diphosphate synthesis" EXACT []
xref: MetaCyc:PWY-5123
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0045338 ! farnesyl diphosphate metabolic process

[Term]
id: GO:0045338
name: farnesyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators]
synonym: "farnesyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0045339
name: farnesyl diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators]
synonym: "farnesyl diphosphate breakdown" EXACT []
synonym: "farnesyl diphosphate catabolism" EXACT []
synonym: "farnesyl diphosphate degradation" EXACT []
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016115 ! terpenoid catabolic process
is_a: GO:0045338 ! farnesyl diphosphate metabolic process

[Term]
id: GO:0045340
name: mercury ion binding
namespace: molecular_function
def: "Binding to a mercury ion (Hg2+)." [GOC:go_curators]
synonym: "Hg ion binding" EXACT []
synonym: "mercury binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0045341
name: MHC class I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators]
synonym: "major histocompatibility complex class I biosynthesis" EXACT []
synonym: "major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "MHC class I anabolism" EXACT []
synonym: "MHC class I biosynthesis" EXACT []
synonym: "MHC class I formation" EXACT []
synonym: "MHC class I synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0045342
name: MHC class II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators]
synonym: "major histocompatibility complex class II biosynthesis" EXACT []
synonym: "major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "MHC class II anabolism" EXACT []
synonym: "MHC class II biosynthesis" EXACT []
synonym: "MHC class II formation" EXACT []
synonym: "MHC class II synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0045343
name: regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "regulation of MHC class I anabolism" EXACT []
synonym: "regulation of MHC class I biosynthesis" EXACT []
synonym: "regulation of MHC class I formation" EXACT []
synonym: "regulation of MHC class I synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045344
name: negative regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "down regulation of MHC class I biosynthetic process" EXACT []
synonym: "down-regulation of MHC class I biosynthetic process" EXACT []
synonym: "downregulation of MHC class I biosynthetic process" EXACT []
synonym: "inhibition of MHC class I biosynthetic process" NARROW []
synonym: "negative regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "negative regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "negative regulation of MHC class I anabolism" EXACT []
synonym: "negative regulation of MHC class I biosynthesis" EXACT []
synonym: "negative regulation of MHC class I formation" EXACT []
synonym: "negative regulation of MHC class I synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045343 ! regulation of MHC class I biosynthetic process
relationship: negatively_regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045345
name: positive regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "activation of MHC class I biosynthetic process" NARROW []
synonym: "positive regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "positive regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "positive regulation of MHC class I anabolism" EXACT []
synonym: "positive regulation of MHC class I biosynthesis" EXACT []
synonym: "positive regulation of MHC class I formation" EXACT []
synonym: "positive regulation of MHC class I synthesis" EXACT []
synonym: "stimulation of MHC class I biosynthetic process" NARROW []
synonym: "up regulation of MHC class I biosynthetic process" EXACT []
synonym: "up-regulation of MHC class I biosynthetic process" EXACT []
synonym: "upregulation of MHC class I biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045343 ! regulation of MHC class I biosynthetic process
relationship: positively_regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045346
name: regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "regulation of MHC class II anabolism" EXACT []
synonym: "regulation of MHC class II biosynthesis" EXACT []
synonym: "regulation of MHC class II formation" EXACT []
synonym: "regulation of MHC class II synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045347
name: negative regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "down regulation of MHC class II biosynthetic process" EXACT []
synonym: "down-regulation of MHC class II biosynthetic process" EXACT []
synonym: "downregulation of MHC class II biosynthetic process" EXACT []
synonym: "inhibition of MHC class II biosynthetic process" NARROW []
synonym: "negative regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "negative regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "negative regulation of MHC class II anabolism" EXACT []
synonym: "negative regulation of MHC class II biosynthesis" EXACT []
synonym: "negative regulation of MHC class II formation" EXACT []
synonym: "negative regulation of MHC class II synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045346 ! regulation of MHC class II biosynthetic process
relationship: negatively_regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045348
name: positive regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "activation of MHC class II biosynthetic process" NARROW []
synonym: "positive regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "positive regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "positive regulation of MHC class II anabolism" EXACT []
synonym: "positive regulation of MHC class II biosynthesis" EXACT []
synonym: "positive regulation of MHC class II formation" EXACT []
synonym: "positive regulation of MHC class II synthesis" EXACT []
synonym: "stimulation of MHC class II biosynthetic process" NARROW []
synonym: "up regulation of MHC class II biosynthetic process" EXACT []
synonym: "up-regulation of MHC class II biosynthetic process" EXACT []
synonym: "upregulation of MHC class II biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045346 ! regulation of MHC class II biosynthetic process
relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045352
name: interleukin-1 type I receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to interleukin-1 type I receptors." [GOC:ebc]
synonym: "IL-1ra type I" EXACT []
is_a: GO:0005152 ! interleukin-1 receptor antagonist activity

[Term]
id: GO:0045353
name: interleukin-1 type II receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to interleukin-1 type II receptors." [GOC:ebc]
synonym: "IL-1ra type II" EXACT []
is_a: GO:0005152 ! interleukin-1 receptor antagonist activity

[Term]
id: GO:0045427
name: obsolete enzyme active site formation via (phospho-5'-guanosine)-L-histidine
namespace: biological_process
def: "OBSOLETE. The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:10529169.
is_obsolete: true

[Term]
id: GO:0045428
name: regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "regulation of nitric oxide anabolism" EXACT []
synonym: "regulation of nitric oxide biosynthesis" EXACT []
synonym: "regulation of nitric oxide formation" EXACT []
synonym: "regulation of nitric oxide synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0080164 ! regulation of nitric oxide metabolic process
relationship: regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045429
name: positive regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "activation of nitric oxide biosynthetic process" NARROW []
synonym: "positive regulation of nitric oxide anabolism" EXACT []
synonym: "positive regulation of nitric oxide biosynthesis" EXACT []
synonym: "positive regulation of nitric oxide formation" EXACT []
synonym: "positive regulation of nitric oxide synthesis" EXACT []
synonym: "stimulation of nitric oxide biosynthetic process" NARROW []
synonym: "up regulation of nitric oxide biosynthetic process" EXACT []
synonym: "up-regulation of nitric oxide biosynthetic process" EXACT []
synonym: "upregulation of nitric oxide biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process
is_a: GO:1904407 ! positive regulation of nitric oxide metabolic process
relationship: positively_regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045430
name: chalcone isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6]
synonym: "chalcone--flavonone isomerase activity" RELATED [EC:5.5.1.6]
synonym: "chalcone-flavanone isomerase activity" EXACT []
synonym: "flavanone lyase (decyclizing)" RELATED [EC:5.5.1.6]
xref: EC:5.5.1.6
xref: MetaCyc:CHALCONE-ISOMERASE-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0045431
name: flavonol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.20.6, ISBN:0943088372, PMID:7904213]
synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" RELATED [EC:1.14.20.6]
synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" RELATED [EC:1.14.20.6]
synonym: "FLS activity" RELATED [EC:1.14.20.6]
xref: EC:1.14.20.6
xref: RHEA:21088
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0045433
name: male courtship behavior, veined wing generated song production
namespace: biological_process
def: "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, song production" BROAD []
synonym: "male courtship behaviour, song production" BROAD []
synonym: "male courtship behaviour, veined wing generated song production" EXACT []
is_a: GO:0008049 ! male courtship behavior
relationship: part_of GO:0016545 ! male courtship behavior, veined wing vibration

[Term]
id: GO:0045434
name: negative regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827]
synonym: "down regulation of female receptivity, post-mating" EXACT []
synonym: "down-regulation of female receptivity, post-mating" EXACT []
synonym: "downregulation of female receptivity, post-mating" EXACT []
synonym: "inhibition of female receptivity, post-mating" NARROW []
is_a: GO:0007621 ! negative regulation of female receptivity
is_a: GO:0046008 ! regulation of female receptivity, post-mating

[Term]
id: GO:0045435
name: lycopene epsilon cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512]
synonym: "lycopene cyclase" BROAD []
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0045436
name: lycopene beta cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512]
synonym: "crtL" RELATED []
synonym: "lycopene cyclase" BROAD []
xref: MetaCyc:RXN1F-150
xref: RHEA:32219
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0045437
name: uridine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + uridine = ribofuranose + uracil." [EC:3.2.2.3, RHEA:15577]
synonym: "uridine hydrolase activity" EXACT []
synonym: "uridine ribohydrolase activity" RELATED [EC:3.2.2.3]
xref: EC:3.2.2.3
xref: KEGG_REACTION:R01080
xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN
xref: RHEA:15577
is_a: GO:0050263 ! ribosylpyrimidine nucleosidase activity

[Term]
id: GO:0045438
name: delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity
namespace: molecular_function
def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333]
synonym: "ACV synthetase activity" BROAD []
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0045439
name: isopenicillin-N epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopenicillin N = penicillin N." [EC:5.1.1.17, RHEA:20033]
synonym: "isopenicillin N epimerase activity" EXACT []
synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" RELATED [EC:5.1.1.17]
xref: EC:5.1.1.17
xref: KEGG_REACTION:R04147
xref: MetaCyc:5.1.1.17-RXN
xref: RHEA:20033
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0045442
name: deacetoxycephalosporin-C hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate." [EC:1.14.11.26, RHEA:16805]
synonym: "3'-methylcephem hydroxylase activity" RELATED [EC:1.14.11.26]
synonym: "beta-lactam hydroxylase activity" EXACT []
synonym: "DACS" RELATED [EC:1.14.11.26]
synonym: "DAOC hydroxylase activity" RELATED [EC:1.14.11.26]
synonym: "deacetoxycephalosporin C hydroxylase activity" RELATED [EC:1.14.11.26]
synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.26]
synonym: "deacetylcephalosporin C synthase activity" RELATED [EC:1.14.11.26]
xref: EC:1.14.11.26
xref: KEGG_REACTION:R05229
xref: MetaCyc:1.14.11.26-RXN
xref: RHEA:16805
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0045443
name: juvenile hormone secretion
namespace: biological_process
def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
is_a: GO:0046865 ! terpenoid transport
is_a: GO:0060986 ! endocrine hormone secretion
is_a: GO:0140353 ! lipid export from cell

[Term]
id: GO:0045444
name: fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators]
synonym: "adipocyte cell differentiation" EXACT []
synonym: "adipocyte differentiation" EXACT []
synonym: "adipogenesis" RELATED []
synonym: "adipose cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0045445
name: myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "myoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0061061 ! muscle structure development

[Term]
id: GO:0045446
name: endothelial cell differentiation
namespace: biological_process
def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0003158 ! endothelium development

[Term]
id: GO:0045448
name: mitotic cell cycle, embryonic
namespace: biological_process
def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
is_a: GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0045450
name: bicoid mRNA localization
namespace: biological_process
def: "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
synonym: "bicoid mRNA localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of bicoid mRNA localization" EXACT []
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification
relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification

[Term]
id: GO:0045451
name: pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "establishment and maintenance of oskar mRNA localization in pole plasm" EXACT []
synonym: "establishment and maintenance of pole plasm oskar mRNA localization" EXACT []
synonym: "oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "pole plasm oskar mRNA localisation" EXACT [GOC:mah]
is_a: GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0045453
name: bone resorption
namespace: biological_process
def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780]
xref: Wikipedia:Bone_resorption
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0046849 ! bone remodeling

[Term]
id: GO:0045454
name: cell redox homeostasis
namespace: biological_process
alt_id: GO:0030503
alt_id: GO:0045867
alt_id: GO:0045868
def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_drosophila
subset: goslim_metagenomics
synonym: "regulation of cell redox homeostasis" RELATED []
synonym: "regulation of redox homeostasis" BROAD []
xref: Wikipedia:Redox
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0045455
name: ecdysteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
synonym: "ecdysteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0042445 ! hormone metabolic process
relationship: part_of GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0045456
name: ecdysteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
synonym: "ecdysteroid anabolism" EXACT []
synonym: "ecdysteroid biosynthesis" EXACT []
synonym: "ecdysteroid formation" EXACT []
synonym: "ecdysteroid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045457
name: ecdysteroid secretion
namespace: biological_process
def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0045458
name: recombination within rDNA repeats
namespace: biological_process
def: "Genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: Note that this term was reinstated from obsolete.
synonym: "recombination within ribosomal DNA repeats" EXACT []
is_a: GO:0006310 ! DNA recombination
is_a: GO:0043007 ! maintenance of rDNA

[Term]
id: GO:0045459
name: obsolete iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide." [PMID:11592901, RESID:AA0326]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0045460
name: sterigmatocystin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248]
synonym: "sterigmatocystin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:0045461
name: sterigmatocystin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248]
synonym: "sterigmatocystin anabolism" EXACT []
synonym: "sterigmatocystin biosynthesis" EXACT []
synonym: "sterigmatocystin formation" EXACT []
synonym: "sterigmatocystin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:0045462
name: trichothecene 3-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973]
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0045463
name: R8 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045464
name: R8 cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339]
is_a: GO:0043704 ! photoreceptor cell fate specification
relationship: part_of GO:0007460 ! R8 cell fate commitment

[Term]
id: GO:0045465
name: R8 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0045466
name: R7 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0045467
name: R7 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045468
name: regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339]
synonym: "R8 cell spacing in compound eye" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of R8 spacing" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0045469
name: negative regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye." [GOC:dph, GOC:tb, PMID:11880339]
synonym: "down regulation of R8 spacing" EXACT []
synonym: "down-regulation of R8 spacing" EXACT []
synonym: "downregulation of R8 spacing" EXACT []
synonym: "inhibition of R8 spacing" NARROW []
is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye

[Term]
id: GO:0045470
name: R8 cell-mediated photoreceptor organization
namespace: biological_process
def: "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339]
synonym: "R8-mediated photoreceptor organisation" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045471
name: response to ethanol
namespace: biological_process
alt_id: GO:0017036
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0045472
name: response to ether
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0045473
name: obsolete response to ethanol (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "response to ethanol (sensu Insecta)" EXACT []
is_obsolete: true
consider: GO:0048149

[Term]
id: GO:0045474
name: obsolete response to ether (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "response to ether (sensu Insecta)" EXACT []
is_obsolete: true
consider: GO:0048150

[Term]
id: GO:0045475
name: locomotor rhythm
namespace: biological_process
def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
synonym: "circadian locomotor activity rhythm" NARROW []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0048512 ! circadian behavior

[Term]
id: GO:0045476
name: nurse cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
synonym: "apoptosis of nurse cells" EXACT []
synonym: "invertebrate nurse cell apoptosis" NARROW []
synonym: "nurse cell apoptosis" NARROW []
synonym: "nurse cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of nurse cells by apoptosis" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! programmed cell death involved in cell development
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0045477
name: regulation of nurse cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306]
synonym: "regulation of nurse cell apoptosis" NARROW []
is_a: GO:1904748 ! regulation of apoptotic process involved in development
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0045476 ! nurse cell apoptotic process

[Term]
id: GO:0045478
name: fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "fusome organisation" EXACT []
synonym: "fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism

[Term]
id: GO:0045479
name: vesicle targeting to fusome
namespace: biological_process
def: "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome." [PMID:9046244]
synonym: "vesicle-fusome targeting" EXACT []
is_a: GO:0006903 ! vesicle targeting
relationship: part_of GO:0045478 ! fusome organization

[Term]
id: GO:0045480
name: galactose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide." [EC:1.1.3.9]
synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9]
synonym: "D-galactose oxidase activity" RELATED [EC:1.1.3.9]
synonym: "D-galactose:oxygen 6-oxidoreductase activity" RELATED [EC:1.1.3.9]
xref: EC:1.1.3.9
xref: MetaCyc:GALACTOSE-OXIDASE-RXN
xref: RHEA:24160
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0045481
name: 6-endo-hydroxycineole dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + H+ + NADH." [EC:1.1.1.241, RHEA:11736]
synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" RELATED [EC:1.1.1.241]
xref: EC:1.1.1.241
xref: KEGG_REACTION:R02994
xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN
xref: RHEA:11736
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045482
name: trichodiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene." [EC:4.2.3.6, RHEA:12052]
synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" RELATED [EC:4.2.3.6]
synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" RELATED [EC:4.2.3.6]
synonym: "trichodiene synthetase activity" RELATED [EC:4.2.3.6]
xref: EC:4.2.3.6
xref: KEGG_REACTION:R02306
xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN
xref: RHEA:12052
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0045483
name: aristolochene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" RELATED [EC:4.2.3.9]
synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9]
synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" RELATED [EC:4.2.3.9]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" RELATED [EC:4.2.3.9]
xref: EC:4.2.3.9
xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN
xref: RHEA:19825
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0045484
name: L-lysine 6-transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine." [EC:2.6.1.36, RHEA:21200]
synonym: "L-lysine aminotransferase activity" RELATED [EC:2.6.1.36]
synonym: "L-lysine transaminase activity" RELATED [EC:2.6.1.36]
synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" RELATED [EC:2.6.1.36]
synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.36]
synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" RELATED [EC:2.6.1.36]
synonym: "lysine 6-aminotransferase activity" EXACT []
synonym: "lysine epsilon-aminotransferase activity" RELATED [EC:2.6.1.36]
synonym: "lysine epsilon-transaminase activity" RELATED [EC:2.6.1.36]
synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" RELATED [EC:2.6.1.36]
xref: EC:2.6.1.36
xref: KEGG_REACTION:R00457
xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN
xref: RHEA:21200
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0045485
name: omega-6 fatty acid desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158]
xref: Reactome:R-HSA-2046089 "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA"
xref: Reactome:R-HSA-2046092 "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA"
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0045486
name: flavanone 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate." [RHEA:18621]
synonym: "(2S)-flavanone 3-hydroxylase activity" RELATED [EC:1.14.11.9]
synonym: "flavanone 3-beta-hydroxylase activity" RELATED [EC:1.14.11.9]
synonym: "flavanone 3-hydroxylase activity" RELATED [EC:1.14.11.9]
synonym: "flavanone 3beta-hydroxylase activity" RELATED [EC:1.14.11.9]
synonym: "flavanone synthase I activity" RELATED [EC:1.14.11.9]
synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.9]
synonym: "naringenin 3-dioxygenase activity" NARROW []
synonym: "naringenin 3-hydroxylase activity" RELATED [EC:1.14.11.9]
synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.9]
xref: EC:1.14.11.9
xref: MetaCyc:1.14.11.9-RXN
xref: RHEA:18621
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0045487
name: gibberellin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [GOC:go_curators]
synonym: "gibberellic acid breakdown" NARROW []
synonym: "gibberellic acid catabolic process" NARROW []
synonym: "gibberellic acid catabolism" NARROW []
synonym: "gibberellic acid degradation" NARROW []
synonym: "gibberellin catabolism" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0045488
name: pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators]
synonym: "pectin metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0045489
name: pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668]
synonym: "pectin anabolism" EXACT []
synonym: "pectin biosynthesis" EXACT []
synonym: "pectin formation" EXACT []
synonym: "pectin synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0045488 ! pectin metabolic process

[Term]
id: GO:0045490
name: pectin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668]
synonym: "pectin breakdown" EXACT []
synonym: "pectin catabolism" EXACT []
synonym: "pectin degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0045488 ! pectin metabolic process

[Term]
id: GO:0045491
name: xylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
synonym: "xylan metabolism" EXACT []
is_a: GO:0010410 ! hemicellulose metabolic process

[Term]
id: GO:0045492
name: xylan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
synonym: "xylan anabolism" EXACT []
synonym: "xylan biosynthesis" EXACT []
synonym: "xylan formation" EXACT []
synonym: "xylan synthesis" EXACT []
is_a: GO:0045491 ! xylan metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0045493
name: xylan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
synonym: "xylan breakdown" EXACT []
synonym: "xylan catabolism" EXACT []
synonym: "xylan degradation" EXACT []
is_a: GO:0045491 ! xylan metabolic process
is_a: GO:2000895 ! hemicellulose catabolic process

[Term]
id: GO:0045494
name: photoreceptor cell maintenance
namespace: biological_process
def: "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0001895 ! retina homeostasis

[Term]
id: GO:0045495
name: pole plasm
namespace: cellular_component
def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
synonym: "germ plasm" NARROW []
synonym: "polar plasm" EXACT []
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0045496
name: male analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0007487 ! analia development

[Term]
id: GO:0045497
name: female analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0007487 ! analia development

[Term]
id: GO:0045498
name: sex comb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0045499
name: chemorepellent activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai]
subset: goslim_pir
synonym: "chemorepellant activity" EXACT []
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0045500
name: sevenless signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085]
synonym: "sev receptor signaling pathway" EXACT []
synonym: "sev signaling pathway" EXACT []
synonym: "sevenless signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0007465 ! R7 cell fate commitment

[Term]
id: GO:0045501
name: regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "regulation of sev signaling pathway" EXACT []
synonym: "regulation of sevenless signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0045676 ! regulation of R7 cell differentiation
relationship: regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045503
name: dynein light chain binding
namespace: molecular_function
def: "Binding to a light chain of the dynein complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045504
name: dynein heavy chain binding
namespace: molecular_function
def: "Binding to a heavy chain of the dynein complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045505
name: dynein intermediate chain binding
namespace: molecular_function
def: "Binding to an intermediate chain of the dynein complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045506
name: interleukin-24 receptor activity
namespace: molecular_function
def: "Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-24 receptor activity" EXACT [GOC:mah]
synonym: "IL-24R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0045507
name: interleukin-25 receptor activity
namespace: molecular_function
def: "Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-25 receptor activity" EXACT [GOC:mah]
synonym: "IL-25R" EXACT []
is_a: GO:0030368 ! interleukin-17 receptor activity

[Term]
id: GO:0045508
name: interleukin-26 receptor activity
namespace: molecular_function
def: "Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-26 receptor activity" EXACT [GOC:mah]
synonym: "IL-26R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0045509
name: interleukin-27 receptor activity
namespace: molecular_function
def: "Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-27 receptor activity" EXACT [GOC:mah]
synonym: "IL-27R" EXACT []
is_a: GO:0030368 ! interleukin-17 receptor activity

[Term]
id: GO:0045510
name: interleukin-24 binding
namespace: molecular_function
def: "Binding to interleukin-24." [GOC:go_curators]
synonym: "IL-24 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045511
name: interleukin-25 binding
namespace: molecular_function
def: "Binding to interleukin-25." [GOC:go_curators]
synonym: "IL-25 binding" EXACT []
is_a: GO:0019975 ! interleukin-17 binding

[Term]
id: GO:0045512
name: interleukin-26 binding
namespace: molecular_function
def: "Binding to interleukin-26." [GOC:go_curators]
synonym: "IL-26 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045513
name: interleukin-27 binding
namespace: molecular_function
def: "Binding to interleukin-27." [GOC:go_curators]
synonym: "IL-27 binding" EXACT []
is_a: GO:0019975 ! interleukin-17 binding

[Term]
id: GO:0045514
name: interleukin-16 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-16 receptor." [GOC:go_curators]
synonym: "IL-16" NARROW []
synonym: "interleukin-16 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045515
name: interleukin-18 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-18 receptor." [GOC:go_curators]
synonym: "IL-18" NARROW []
synonym: "interleukin-18 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045516
name: interleukin-19 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-19 receptor." [GOC:go_curators]
synonym: "IL-19" NARROW []
synonym: "interleukin-19 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045517
name: interleukin-20 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-20 receptor." [GOC:go_curators]
synonym: "IL-20" NARROW []
synonym: "interleukin-20 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045518
name: interleukin-22 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-22 receptor." [GOC:go_curators]
synonym: "IL-22" NARROW []
synonym: "interleukin-22 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045519
name: interleukin-23 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-23 receptor." [GOC:go_curators]
synonym: "IL-23" NARROW []
synonym: "interleukin-23 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045520
name: interleukin-24 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-24 receptor." [GOC:go_curators]
synonym: "IL-24" NARROW []
synonym: "interleukin-24 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045521
name: interleukin-25 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-25 receptor." [GOC:go_curators]
synonym: "IL-25" NARROW []
synonym: "interleukin-25 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045522
name: interleukin-26 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-26 receptor." [GOC:go_curators]
synonym: "IL-26" NARROW []
synonym: "interleukin-26 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045523
name: interleukin-27 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-27 receptor." [GOC:go_curators]
synonym: "IL-27" NARROW []
synonym: "interleukin-27 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045540
name: regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "regulation of cholesterol anabolism" EXACT []
synonym: "regulation of cholesterol biosynthesis" EXACT []
synonym: "regulation of cholesterol formation" EXACT []
synonym: "regulation of cholesterol synthesis" EXACT []
is_a: GO:0090181 ! regulation of cholesterol metabolic process
is_a: GO:0106118 ! regulation of sterol biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045541
name: negative regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "down regulation of cholesterol biosynthetic process" EXACT []
synonym: "down-regulation of cholesterol biosynthetic process" EXACT []
synonym: "downregulation of cholesterol biosynthetic process" EXACT []
synonym: "inhibition of cholesterol biosynthetic process" NARROW []
synonym: "negative regulation of cholesterol anabolism" EXACT []
synonym: "negative regulation of cholesterol biosynthesis" EXACT []
synonym: "negative regulation of cholesterol formation" EXACT []
synonym: "negative regulation of cholesterol synthesis" EXACT []
is_a: GO:0045540 ! regulation of cholesterol biosynthetic process
is_a: GO:0090206 ! negative regulation of cholesterol metabolic process
is_a: GO:0106119 ! negative regulation of sterol biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045542
name: positive regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "activation of cholesterol biosynthetic process" NARROW []
synonym: "positive regulation of cholesterol anabolism" EXACT []
synonym: "positive regulation of cholesterol biosynthesis" EXACT []
synonym: "positive regulation of cholesterol formation" EXACT []
synonym: "positive regulation of cholesterol synthesis" EXACT []
synonym: "stimulation of cholesterol biosynthetic process" NARROW []
synonym: "up regulation of cholesterol biosynthetic process" EXACT []
synonym: "up-regulation of cholesterol biosynthetic process" EXACT []
synonym: "upregulation of cholesterol biosynthetic process" EXACT []
is_a: GO:0045540 ! regulation of cholesterol biosynthetic process
is_a: GO:0090205 ! positive regulation of cholesterol metabolic process
is_a: GO:0106120 ! positive regulation of sterol biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045543
name: gibberellin 2-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2." [EC:1.14.11.13, PMID:32652020]
synonym: "gibberellin 2-beta-hydroxylase activity" RELATED [EC:1.14.11.13]
synonym: "gibberellin 2-oxidase activity" EXACT []
synonym: "gibberellin 2beta-dioxygenase activity" RELATED [EC:1.14.11.13]
synonym: "gibberellin 2beta-hydroxylase activity" RELATED [EC:1.14.11.13]
xref: EC:1.14.11.13
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0045544
name: gibberellin 20-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 2-oxoglutarate + gibberellin A12 (GA12) + H+ + 3 O2 = 3 CO2 + gibberellin A9 (GA9) + 2 H2O + 2 succinate. This reaction results in the oxidation of C-20 gibberellins to form the corresponding C-19 lactones, via a three-step oxidation at C-20 of the GA skeleton. Also converts GA53 to GA20. GA25 is also formed as a minor product." [PMID:32652020, PMID:7604047]
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0045545
name: syndecan binding
namespace: molecular_function
def: "Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, PMID:9355727]
is_a: GO:0043394 ! proteoglycan binding

[Term]
id: GO:0045547
name: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate." [PMID:9858571, RHEA:53008]
synonym: "dehydrodolichyl diphosphate synthase activity" EXACT [EC:2.5.1.87]
xref: EC:2.5.1.87
xref: RHEA:53008
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0045548
name: phenylalanine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate." [RHEA:21384]
synonym: "L-phenylalanine ammonia-lyase activity" RELATED [EC:4.3.1.24]
synonym: "PAL activity" BROAD [EC:4.3.1.24]
synonym: "phe ammonia-lyase activity" RELATED [EC:4.3.1.24]
synonym: "phenylalanine ammonium-lyase activity" RELATED [EC:4.3.1.24]
synonym: "phenylalanine deaminase activity" RELATED [EC:4.3.1.24]
xref: EC:4.3.1.24
xref: RHEA:21384
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0045549
name: 9-cis-epoxycarotenoid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51]
synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" RELATED [EC:1.13.11.51]
synonym: "AtNCED3" RELATED [EC:1.13.11.51]
synonym: "NCED" RELATED [EC:1.13.11.51]
synonym: "neoxanthin cleavage enzyme" RELATED []
synonym: "nine-cis-epoxycarotenoid dioxygenase activity" RELATED [EC:1.13.11.51]
synonym: "PvNCED1" RELATED [EC:1.13.11.51]
synonym: "VP14" RELATED [EC:1.13.11.51]
xref: EC:1.13.11.51
is_a: GO:0010436 ! carotenoid dioxygenase activity

[Term]
id: GO:0045550
name: geranylgeranyl reductase activity
namespace: molecular_function
def: "Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group." [PMID:9492312]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0045551
name: cinnamyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. Also acts on coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol." [EC:1.1.1.195]
synonym: "CAD activity" BROAD [EC:1.1.1.195]
synonym: "cinnamyl alcohol dehydrogenase activity" RELATED [EC:1.1.1.195]
synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.195]
xref: EC:1.1.1.195
xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045552
name: dihydrokaempferol 4-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219]
synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.219]
synonym: "dihydroflavanol 4-reductase activity" RELATED [EC:1.1.1.219]
synonym: "dihydroflavonol 4-reductase activity" RELATED [EC:1.1.1.219]
synonym: "dihydromyricetin reductase activity" RELATED [EC:1.1.1.219]
synonym: "dihydroquercetin reductase activity" RELATED [EC:1.1.1.219]
synonym: "NADPH-dihydromyricetin reductase activity" RELATED [EC:1.1.1.219]
xref: EC:1.1.1.219
xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN
xref: RHEA:23016
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045557
name: obsolete TRAIL receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "TRAIL receptor anabolism" EXACT []
synonym: "TRAIL receptor biosynthesis" EXACT []
synonym: "TRAIL receptor formation" EXACT []
synonym: "TRAIL receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045558
name: obsolete TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway." [GOC:go_curators, PMID:9311998]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "TRAIL receptor 1 anabolism" EXACT []
synonym: "TRAIL receptor 1 biosynthesis" EXACT []
synonym: "TRAIL receptor 1 formation" EXACT []
synonym: "TRAIL receptor 1 synthesis" EXACT []
synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PR:000002108]
is_obsolete: true

[Term]
id: GO:0045559
name: obsolete TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1." [GOC:go_curators, PMID:9311998]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "TRAIL receptor 2 anabolism" EXACT []
synonym: "TRAIL receptor 2 biosynthesis" EXACT []
synonym: "TRAIL receptor 2 formation" EXACT []
synonym: "TRAIL receptor 2 synthesis" EXACT []
synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PR:000002109]
is_obsolete: true

[Term]
id: GO:0045560
name: obsolete regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "regulation of TRAIL receptor anabolism" EXACT []
synonym: "regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor formation" EXACT []
synonym: "regulation of TRAIL receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045561
name: obsolete regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor 1 formation" EXACT []
synonym: "regulation of TRAIL receptor 1 synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045562
name: obsolete regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor 2 formation" EXACT []
synonym: "regulation of TRAIL receptor 2 synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045563
name: obsolete negative regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "down regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor formation" EXACT []
synonym: "negative regulation of TRAIL receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045564
name: obsolete positive regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "activation of TRAIL receptor biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor formation" EXACT []
synonym: "positive regulation of TRAIL receptor synthesis" EXACT []
synonym: "stimulation of TRAIL receptor biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0045565
name: obsolete negative regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "down regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor 1 formation" EXACT []
synonym: "negative regulation of TRAIL receptor 1 synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045566
name: obsolete positive regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "activation of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor 1 formation" EXACT []
synonym: "positive regulation of TRAIL receptor 1 synthesis" EXACT []
synonym: "stimulation of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor 1 biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0045567
name: obsolete negative regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "down regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor 2 formation" EXACT []
synonym: "negative regulation of TRAIL receptor 2 synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045568
name: obsolete positive regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "activation of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor 2 formation" EXACT []
synonym: "positive regulation of TRAIL receptor 2 synthesis" EXACT []
synonym: "stimulation of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor 2 biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0045569
name: TRAIL binding
namespace: molecular_function
def: "Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980]
subset: goslim_chembl
synonym: "Apo-2L binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045570
name: regulation of imaginal disc growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045571
name: negative regulation of imaginal disc growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
synonym: "down regulation of imaginal disc growth" EXACT []
synonym: "down-regulation of imaginal disc growth" EXACT []
synonym: "downregulation of imaginal disc growth" EXACT []
synonym: "inhibition of imaginal disc growth" NARROW []
is_a: GO:0045570 ! regulation of imaginal disc growth
is_a: GO:0048640 ! negative regulation of developmental growth
relationship: negatively_regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045572
name: positive regulation of imaginal disc growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
synonym: "activation of imaginal disc growth" NARROW []
synonym: "stimulation of imaginal disc growth" NARROW []
synonym: "up regulation of imaginal disc growth" EXACT []
synonym: "up-regulation of imaginal disc growth" EXACT []
synonym: "upregulation of imaginal disc growth" EXACT []
is_a: GO:0045570 ! regulation of imaginal disc growth
is_a: GO:0048639 ! positive regulation of developmental growth
relationship: positively_regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045574
name: sterigmatocystin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators]
synonym: "sterigmatocystin breakdown" EXACT []
synonym: "sterigmatocystin catabolism" EXACT []
synonym: "sterigmatocystin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process

[Term]
id: GO:0045575
name: basophil activation
namespace: biological_process
def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149]
xref: Wikipedia:Basophil_activation
is_a: GO:0036230 ! granulocyte activation

[Term]
id: GO:0045576
name: mast cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0045577
name: regulation of B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of B cell development" RELATED [GOC:add]
synonym: "regulation of B lymphocyte differentiation" EXACT []
synonym: "regulation of B-cell differentiation" EXACT []
synonym: "regulation of B-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050864 ! regulation of B cell activation
relationship: regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045578
name: negative regulation of B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of B cell differentiation" EXACT []
synonym: "down-regulation of B cell differentiation" EXACT []
synonym: "downregulation of B cell differentiation" EXACT []
synonym: "inhibition of B cell differentiation" NARROW []
synonym: "negative regulation of B cell development" RELATED [GOC:add]
synonym: "negative regulation of B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-cell differentiation" EXACT []
synonym: "negative regulation of B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050869 ! negative regulation of B cell activation
relationship: negatively_regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045579
name: positive regulation of B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of B cell differentiation" NARROW []
synonym: "positive regulation of B cell development" RELATED [GOC:add]
synonym: "positive regulation of B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-cell differentiation" EXACT []
synonym: "positive regulation of B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B cell differentiation" NARROW []
synonym: "up regulation of B cell differentiation" EXACT []
synonym: "up-regulation of B cell differentiation" EXACT []
synonym: "upregulation of B cell differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050871 ! positive regulation of B cell activation
relationship: positively_regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045580
name: regulation of T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T cell development" RELATED [GOC:add]
synonym: "regulation of T lymphocyte differentiation" EXACT []
synonym: "regulation of T-cell differentiation" EXACT []
synonym: "regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045581
name: negative regulation of T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T cell differentiation" EXACT []
synonym: "down-regulation of T cell differentiation" EXACT []
synonym: "downregulation of T cell differentiation" EXACT []
synonym: "inhibition of T cell differentiation" NARROW []
synonym: "negative regulation of T cell development" RELATED [GOC:add]
synonym: "negative regulation of T lymphocyte differentiation" EXACT []
synonym: "negative regulation of T-cell differentiation" EXACT []
synonym: "negative regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045582
name: positive regulation of T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T cell differentiation" NARROW []
synonym: "positive regulation of T cell development" RELATED [GOC:add]
synonym: "positive regulation of T lymphocyte differentiation" EXACT []
synonym: "positive regulation of T-cell differentiation" EXACT []
synonym: "positive regulation of T-lymphocyte differentiation" EXACT []
synonym: "stimulation of T cell differentiation" NARROW []
synonym: "up regulation of T cell differentiation" EXACT []
synonym: "up-regulation of T cell differentiation" EXACT []
synonym: "upregulation of T cell differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045583
name: regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of cytotoxic T cell development" RELATED [GOC:add]
synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045584
name: negative regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of cytotoxic T cell differentiation" EXACT []
synonym: "down-regulation of cytotoxic T cell differentiation" EXACT []
synonym: "downregulation of cytotoxic T cell differentiation" EXACT []
synonym: "inhibition of cytotoxic T cell differentiation" NARROW []
synonym: "negative regulation of cytotoxic T cell development" RELATED [GOC:add]
synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation
relationship: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045585
name: positive regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of cytotoxic T cell differentiation" NARROW []
synonym: "positive regulation of cytotoxic T cell development" RELATED [GOC:add]
synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT []
synonym: "stimulation of cytotoxic T cell differentiation" NARROW []
synonym: "up regulation of cytotoxic T cell differentiation" EXACT []
synonym: "up-regulation of cytotoxic T cell differentiation" EXACT []
synonym: "upregulation of cytotoxic T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation
relationship: positively_regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045586
name: regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of gamma-delta T cell development" RELATED [GOC:add]
synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
relationship: regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045587
name: negative regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of gamma-delta T cell differentiation" EXACT []
synonym: "down-regulation of gamma-delta T cell differentiation" EXACT []
synonym: "downregulation of gamma-delta T cell differentiation" EXACT []
synonym: "inhibition of gamma-delta T cell differentiation" NARROW []
synonym: "negative regulation of gamma-delta T cell development" RELATED [GOC:add]
synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
relationship: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045588
name: positive regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of gamma-delta T cell differentiation" NARROW []
synonym: "positive regulation of gamma-delta T cell development" RELATED [GOC:add]
synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of gamma-delta T cell differentiation" NARROW []
synonym: "up regulation of gamma-delta T cell differentiation" EXACT []
synonym: "up-regulation of gamma-delta T cell differentiation" EXACT []
synonym: "upregulation of gamma-delta T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
relationship: positively_regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045589
name: regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of regulatory T cell development" RELATED [GOC:add]
synonym: "regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "regulation of regulatory T-cell differentiation" EXACT []
synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "regulation of suppressor T cell differentiation" EXACT []
synonym: "regulation of suppressor T lymphocyte differentiation" EXACT []
synonym: "regulation of suppressor T-cell differentiation" EXACT []
synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045590
name: negative regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of regulatory T cell differentiation" EXACT []
synonym: "down-regulation of regulatory T cell differentiation" EXACT []
synonym: "downregulation of regulatory T cell differentiation" EXACT []
synonym: "inhibition of regulatory T cell differentiation" NARROW []
synonym: "negative regulation of regulatory T cell development" RELATED [GOC:add]
synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of regulatory T-cell differentiation" EXACT []
synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of suppressor T cell differentiation" EXACT []
synonym: "negative regulation of suppressor T-cell differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
relationship: negatively_regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045591
name: positive regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of regulatory T cell differentiation" NARROW []
synonym: "positive regulation of regulatory T cell development" RELATED [GOC:add]
synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of regulatory T-cell differentiation" EXACT []
synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of suppressor T cell differentiation" EXACT []
synonym: "positive regulation of suppressor T-cell differentiation" EXACT []
synonym: "stimulation of regulatory T cell differentiation" NARROW []
synonym: "up regulation of regulatory T cell differentiation" EXACT []
synonym: "up-regulation of regulatory T cell differentiation" EXACT []
synonym: "upregulation of regulatory T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
relationship: positively_regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045592
name: regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "regulation of ovarian cumulus cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:2000387 ! regulation of antral ovarian follicle growth
relationship: regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045593
name: negative regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "down regulation of cumulus cell differentiation" EXACT []
synonym: "down-regulation of cumulus cell differentiation" EXACT []
synonym: "downregulation of cumulus cell differentiation" EXACT []
synonym: "inhibition of cumulus cell differentiation" NARROW []
synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045592 ! regulation of cumulus cell differentiation
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045594
name: positive regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "activation of cumulus cell differentiation" NARROW []
synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT []
synonym: "stimulation of cumulus cell differentiation" NARROW []
synonym: "up regulation of cumulus cell differentiation" EXACT []
synonym: "up-regulation of cumulus cell differentiation" EXACT []
synonym: "upregulation of cumulus cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045592 ! regulation of cumulus cell differentiation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045595
name: regulation of cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045596
name: negative regulation of cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
synonym: "down regulation of cell differentiation" EXACT []
synonym: "down-regulation of cell differentiation" EXACT []
synonym: "downregulation of cell differentiation" EXACT []
synonym: "inhibition of cell differentiation" NARROW []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045597
name: positive regulation of cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]
synonym: "activation of cell differentiation" NARROW []
synonym: "stimulation of cell differentiation" NARROW []
synonym: "up regulation of cell differentiation" EXACT []
synonym: "up-regulation of cell differentiation" EXACT []
synonym: "upregulation of cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045598
name: regulation of fat cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "regulation of adipocyte cell differentiation" EXACT []
synonym: "regulation of adipocyte differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045599
name: negative regulation of fat cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "down regulation of fat cell differentiation" EXACT []
synonym: "down-regulation of fat cell differentiation" EXACT []
synonym: "downregulation of fat cell differentiation" EXACT []
synonym: "inhibition of fat cell differentiation" NARROW []
synonym: "negative regulation of adipocyte cell differentiation" EXACT []
synonym: "negative regulation of adipocyte differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
relationship: negatively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045600
name: positive regulation of fat cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "activation of fat cell differentiation" NARROW []
synonym: "positive regulation of adipocyte cell differentiation" EXACT []
synonym: "positive regulation of adipocyte differentiation" EXACT []
synonym: "stimulation of fat cell differentiation" NARROW []
synonym: "up regulation of fat cell differentiation" EXACT []
synonym: "up-regulation of fat cell differentiation" EXACT []
synonym: "upregulation of fat cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
relationship: positively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045601
name: regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045602
name: negative regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "down regulation of endothelial cell differentiation" EXACT []
synonym: "down-regulation of endothelial cell differentiation" EXACT []
synonym: "downregulation of endothelial cell differentiation" EXACT []
synonym: "inhibition of endothelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045603
name: positive regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "activation of endothelial cell differentiation" NARROW []
synonym: "stimulation of endothelial cell differentiation" NARROW []
synonym: "up regulation of endothelial cell differentiation" EXACT []
synonym: "up-regulation of endothelial cell differentiation" EXACT []
synonym: "upregulation of endothelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
relationship: positively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045604
name: regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045682 ! regulation of epidermis development
relationship: regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045605
name: negative regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "down regulation of epidermal cell differentiation" EXACT []
synonym: "down-regulation of epidermal cell differentiation" EXACT []
synonym: "downregulation of epidermal cell differentiation" EXACT []
synonym: "inhibition of epidermal cell differentiation" NARROW []
synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045683 ! negative regulation of epidermis development
relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045606
name: positive regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "activation of epidermal cell differentiation" NARROW []
synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermal cell differentiation" NARROW []
synonym: "up regulation of epidermal cell differentiation" EXACT []
synonym: "up-regulation of epidermal cell differentiation" EXACT []
synonym: "upregulation of epidermal cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045684 ! positive regulation of epidermis development
relationship: positively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045607
name: regulation of inner ear auditory receptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "regulation of auditory hair cell differentiation" EXACT []
synonym: "regulation of auditory receptor cell differentiation" RELATED []
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation
relationship: regulates GO:0042491 ! inner ear auditory receptor cell differentiation

[Term]
id: GO:0045608
name: negative regulation of inner ear auditory receptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "down regulation of auditory receptor cell differentiation" EXACT []
synonym: "down-regulation of auditory receptor cell differentiation" EXACT []
synonym: "downregulation of auditory receptor cell differentiation" EXACT []
synonym: "inhibition of auditory receptor cell differentiation" NARROW []
synonym: "negative regulation of auditory hair cell differentiation" EXACT []
synonym: "negative regulation of auditory receptor cell differentiation" RELATED []
is_a: GO:0045605 ! negative regulation of epidermal cell differentiation
is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation
is_a: GO:2000981 ! negative regulation of inner ear receptor cell differentiation
relationship: negatively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation

[Term]
id: GO:0045609
name: positive regulation of inner ear auditory receptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "activation of auditory receptor cell differentiation" NARROW []
synonym: "positive regulation of auditory hair cell differentiation" EXACT []
synonym: "positive regulation of auditory receptor cell differentiation" RELATED []
synonym: "stimulation of auditory receptor cell differentiation" NARROW []
synonym: "up regulation of auditory receptor cell differentiation" EXACT []
synonym: "up-regulation of auditory receptor cell differentiation" EXACT []
synonym: "upregulation of auditory receptor cell differentiation" EXACT []
is_a: GO:0045606 ! positive regulation of epidermal cell differentiation
is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation
is_a: GO:2000982 ! positive regulation of inner ear receptor cell differentiation
relationship: positively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation

[Term]
id: GO:0045610
name: regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "regulation of arthropod blood cell differentiation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045611
name: negative regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "down regulation of hemocyte differentiation" EXACT []
synonym: "down-regulation of hemocyte differentiation" EXACT []
synonym: "downregulation of hemocyte differentiation" EXACT []
synonym: "inhibition of hemocyte differentiation" NARROW []
synonym: "negative regulation of arthropod blood cell differentiation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: negatively_regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045612
name: positive regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "activation of hemocyte differentiation" NARROW []
synonym: "positive regulation of arthropod blood cell differentiation" EXACT []
synonym: "stimulation of hemocyte differentiation" NARROW []
synonym: "up regulation of hemocyte differentiation" EXACT []
synonym: "up-regulation of hemocyte differentiation" EXACT []
synonym: "upregulation of hemocyte differentiation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: positively_regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045613
name: regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045614
name: negative regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
synonym: "down regulation of plasmatocyte differentiation" EXACT []
synonym: "down-regulation of plasmatocyte differentiation" EXACT []
synonym: "downregulation of plasmatocyte differentiation" EXACT []
synonym: "inhibition of plasmatocyte differentiation" NARROW []
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
is_a: GO:0045613 ! regulation of plasmatocyte differentiation
relationship: negatively_regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045615
name: positive regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
synonym: "activation of plasmatocyte differentiation" NARROW []
synonym: "stimulation of plasmatocyte differentiation" NARROW []
synonym: "up regulation of plasmatocyte differentiation" EXACT []
synonym: "up-regulation of plasmatocyte differentiation" EXACT []
synonym: "upregulation of plasmatocyte differentiation" EXACT []
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
is_a: GO:0045613 ! regulation of plasmatocyte differentiation
relationship: positively_regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045616
name: regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
is_a: GO:0045604 ! regulation of epidermal cell differentiation
relationship: regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045617
name: negative regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
synonym: "down regulation of keratinocyte differentiation" EXACT []
synonym: "down-regulation of keratinocyte differentiation" EXACT []
synonym: "downregulation of keratinocyte differentiation" EXACT []
synonym: "inhibition of keratinocyte differentiation" NARROW []
is_a: GO:0045605 ! negative regulation of epidermal cell differentiation
is_a: GO:0045616 ! regulation of keratinocyte differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045618
name: positive regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
synonym: "activation of keratinocyte differentiation" NARROW []
synonym: "stimulation of keratinocyte differentiation" NARROW []
synonym: "up regulation of keratinocyte differentiation" EXACT []
synonym: "up-regulation of keratinocyte differentiation" EXACT []
synonym: "upregulation of keratinocyte differentiation" EXACT []
is_a: GO:0045606 ! positive regulation of epidermal cell differentiation
is_a: GO:0045616 ! regulation of keratinocyte differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045619
name: regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0051249 ! regulation of lymphocyte activation
is_a: GO:1902105 ! regulation of leukocyte differentiation
relationship: regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045620
name: negative regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of lymphocyte differentiation" EXACT []
synonym: "down-regulation of lymphocyte differentiation" EXACT []
synonym: "downregulation of lymphocyte differentiation" EXACT []
synonym: "inhibition of lymphocyte differentiation" NARROW []
synonym: "negative regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045621
name: positive regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of lymphocyte differentiation" NARROW []
synonym: "positive regulation of lymphocyte development" RELATED [GOC:add]
synonym: "stimulation of lymphocyte differentiation" NARROW []
synonym: "up regulation of lymphocyte differentiation" EXACT []
synonym: "up-regulation of lymphocyte differentiation" EXACT []
synonym: "upregulation of lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
relationship: positively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045622
name: regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T-helper cell development" RELATED [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045623
name: negative regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T-helper cell differentiation" EXACT []
synonym: "down-regulation of T-helper cell differentiation" EXACT []
synonym: "downregulation of T-helper cell differentiation" EXACT []
synonym: "inhibition of T-helper cell differentiation" NARROW []
synonym: "negative regulation of T-helper cell development" RELATED [GOC:add]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045622 ! regulation of T-helper cell differentiation
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045624
name: positive regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T-helper cell differentiation" NARROW []
synonym: "positive regulation of T-helper cell development" RELATED [GOC:add]
synonym: "stimulation of T-helper cell differentiation" NARROW []
synonym: "up regulation of T-helper cell differentiation" EXACT []
synonym: "up-regulation of T-helper cell differentiation" EXACT []
synonym: "upregulation of T-helper cell differentiation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045622 ! regulation of T-helper cell differentiation
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045625
name: regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T-helper 1 cell development" RELATED [GOC:add]
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation
relationship: regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045626
name: negative regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T-helper 1 cell differentiation" EXACT []
synonym: "down-regulation of T-helper 1 cell differentiation" EXACT []
synonym: "downregulation of T-helper 1 cell differentiation" EXACT []
synonym: "inhibition of T-helper 1 cell differentiation" NARROW []
synonym: "negative regulation of T-helper 1 cell development" RELATED [GOC:add]
is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation
relationship: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045627
name: positive regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T-helper 1 cell differentiation" NARROW []
synonym: "positive regulation of T-helper 1 cell development" RELATED [GOC:add]
synonym: "stimulation of T-helper 1 cell differentiation" NARROW []
synonym: "up regulation of T-helper 1 cell differentiation" EXACT []
synonym: "up-regulation of T-helper 1 cell differentiation" EXACT []
synonym: "upregulation of T-helper 1 cell differentiation" EXACT []
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation
relationship: positively_regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045628
name: regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T-helper 2 cell development" RELATED [GOC:add]
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation
relationship: regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045629
name: negative regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T-helper 2 cell differentiation" EXACT []
synonym: "down-regulation of T-helper 2 cell differentiation" EXACT []
synonym: "downregulation of T-helper 2 cell differentiation" EXACT []
synonym: "inhibition of T-helper 2 cell differentiation" NARROW []
synonym: "negative regulation of T-helper 2 cell development" RELATED [GOC:add]
is_a: GO:0002829 ! negative regulation of type 2 immune response
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation
relationship: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045630
name: positive regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T-helper 2 cell differentiation" NARROW []
synonym: "positive regulation of T-helper 2 cell development" RELATED [GOC:add]
synonym: "stimulation of T-helper 2 cell differentiation" NARROW []
synonym: "up regulation of T-helper 2 cell differentiation" EXACT []
synonym: "up-regulation of T-helper 2 cell differentiation" EXACT []
synonym: "upregulation of T-helper 2 cell differentiation" EXACT []
is_a: GO:0002830 ! positive regulation of type 2 immune response
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation
relationship: positively_regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045631
name: regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045632
name: negative regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
synonym: "down regulation of mechanoreceptor differentiation" EXACT []
synonym: "down-regulation of mechanoreceptor differentiation" EXACT []
synonym: "downregulation of mechanoreceptor differentiation" EXACT []
synonym: "inhibition of mechanoreceptor differentiation" NARROW []
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
is_a: GO:0045665 ! negative regulation of neuron differentiation
relationship: negatively_regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045633
name: positive regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
synonym: "activation of mechanoreceptor differentiation" NARROW []
synonym: "stimulation of mechanoreceptor differentiation" NARROW []
synonym: "up regulation of mechanoreceptor differentiation" EXACT []
synonym: "up-regulation of mechanoreceptor differentiation" EXACT []
synonym: "upregulation of mechanoreceptor differentiation" EXACT []
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
is_a: GO:0045666 ! positive regulation of neuron differentiation
relationship: positively_regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045634
name: regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "regulation of melanophore differentiation" EXACT []
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045635
name: negative regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "down regulation of melanocyte differentiation" EXACT []
synonym: "down-regulation of melanocyte differentiation" EXACT []
synonym: "downregulation of melanocyte differentiation" EXACT []
synonym: "inhibition of melanocyte differentiation" NARROW []
synonym: "negative regulation of melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045636
name: positive regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "activation of melanocyte differentiation" NARROW []
synonym: "positive regulation of melanophore differentiation" EXACT []
synonym: "stimulation of melanocyte differentiation" NARROW []
synonym: "up regulation of melanocyte differentiation" EXACT []
synonym: "up-regulation of melanocyte differentiation" EXACT []
synonym: "upregulation of melanocyte differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045637
name: regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
is_a: GO:1903706 ! regulation of hemopoiesis
relationship: regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045638
name: negative regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "down regulation of myeloid cell differentiation" EXACT []
synonym: "down-regulation of myeloid cell differentiation" EXACT []
synonym: "downregulation of myeloid cell differentiation" EXACT []
synonym: "inhibition of myeloid cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045639
name: positive regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "activation of myeloid cell differentiation" NARROW []
synonym: "stimulation of myeloid cell differentiation" NARROW []
synonym: "up regulation of myeloid cell differentiation" EXACT []
synonym: "up-regulation of myeloid cell differentiation" EXACT []
synonym: "upregulation of myeloid cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: positively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045640
name: regulation of basophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045641
name: negative regulation of basophil differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
synonym: "down regulation of basophil differentiation" EXACT []
synonym: "down-regulation of basophil differentiation" EXACT []
synonym: "downregulation of basophil differentiation" EXACT []
synonym: "inhibition of basophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045640 ! regulation of basophil differentiation
relationship: negatively_regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045642
name: positive regulation of basophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
synonym: "activation of basophil differentiation" NARROW []
synonym: "stimulation of basophil differentiation" NARROW []
synonym: "up regulation of basophil differentiation" EXACT []
synonym: "up-regulation of basophil differentiation" EXACT []
synonym: "upregulation of basophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045640 ! regulation of basophil differentiation
relationship: positively_regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045643
name: regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045644
name: negative regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
synonym: "down regulation of eosinophil differentiation" EXACT []
synonym: "down-regulation of eosinophil differentiation" EXACT []
synonym: "downregulation of eosinophil differentiation" EXACT []
synonym: "inhibition of eosinophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045643 ! regulation of eosinophil differentiation
relationship: negatively_regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045645
name: positive regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
synonym: "activation of eosinophil differentiation" NARROW []
synonym: "stimulation of eosinophil differentiation" NARROW []
synonym: "up regulation of eosinophil differentiation" EXACT []
synonym: "up-regulation of eosinophil differentiation" EXACT []
synonym: "upregulation of eosinophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045643 ! regulation of eosinophil differentiation
relationship: positively_regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045646
name: regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045647
name: negative regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "down regulation of erythrocyte differentiation" EXACT []
synonym: "down-regulation of erythrocyte differentiation" EXACT []
synonym: "downregulation of erythrocyte differentiation" EXACT []
synonym: "inhibition of erythrocyte differentiation" NARROW []
synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045648
name: positive regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "activation of erythrocyte differentiation" NARROW []
synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232]
synonym: "stimulation of erythrocyte differentiation" NARROW []
synonym: "up regulation of erythrocyte differentiation" EXACT []
synonym: "up-regulation of erythrocyte differentiation" EXACT []
synonym: "upregulation of erythrocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
relationship: positively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045649
name: regulation of macrophage differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045650
name: negative regulation of macrophage differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "down regulation of macrophage differentiation" EXACT []
synonym: "down-regulation of macrophage differentiation" EXACT []
synonym: "downregulation of macrophage differentiation" EXACT []
synonym: "inhibition of macrophage differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
relationship: negatively_regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045651
name: positive regulation of macrophage differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "activation of macrophage differentiation" NARROW []
synonym: "stimulation of macrophage differentiation" NARROW []
synonym: "up regulation of macrophage differentiation" EXACT []
synonym: "up-regulation of macrophage differentiation" EXACT []
synonym: "upregulation of macrophage differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
relationship: positively_regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045652
name: regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045653
name: negative regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "down regulation of megakaryocyte differentiation" EXACT []
synonym: "down-regulation of megakaryocyte differentiation" EXACT []
synonym: "downregulation of megakaryocyte differentiation" EXACT []
synonym: "inhibition of megakaryocyte differentiation" NARROW []
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045654
name: positive regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "activation of megakaryocyte differentiation" NARROW []
synonym: "stimulation of megakaryocyte differentiation" NARROW []
synonym: "up regulation of megakaryocyte differentiation" EXACT []
synonym: "up-regulation of megakaryocyte differentiation" EXACT []
synonym: "upregulation of megakaryocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045655
name: regulation of monocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045656
name: negative regulation of monocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "down regulation of monocyte differentiation" EXACT []
synonym: "down-regulation of monocyte differentiation" EXACT []
synonym: "downregulation of monocyte differentiation" EXACT []
synonym: "inhibition of monocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
relationship: negatively_regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045657
name: positive regulation of monocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "activation of monocyte differentiation" NARROW []
synonym: "stimulation of monocyte differentiation" NARROW []
synonym: "up regulation of monocyte differentiation" EXACT []
synonym: "up-regulation of monocyte differentiation" EXACT []
synonym: "upregulation of monocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
relationship: positively_regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045658
name: regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045659
name: negative regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
synonym: "down regulation of neutrophil differentiation" EXACT []
synonym: "down-regulation of neutrophil differentiation" EXACT []
synonym: "downregulation of neutrophil differentiation" EXACT []
synonym: "inhibition of neutrophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045658 ! regulation of neutrophil differentiation
relationship: negatively_regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045660
name: positive regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
synonym: "activation of neutrophil differentiation" NARROW []
synonym: "stimulation of neutrophil differentiation" NARROW []
synonym: "up regulation of neutrophil differentiation" EXACT []
synonym: "up-regulation of neutrophil differentiation" EXACT []
synonym: "upregulation of neutrophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045658 ! regulation of neutrophil differentiation
relationship: positively_regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045661
name: regulation of myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045662
name: negative regulation of myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "down regulation of myoblast differentiation" EXACT []
synonym: "down-regulation of myoblast differentiation" EXACT []
synonym: "downregulation of myoblast differentiation" EXACT []
synonym: "inhibition of myoblast differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045661 ! regulation of myoblast differentiation
relationship: negatively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045663
name: positive regulation of myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "activation of myoblast differentiation" NARROW []
synonym: "stimulation of myoblast differentiation" NARROW []
synonym: "up regulation of myoblast differentiation" EXACT []
synonym: "up-regulation of myoblast differentiation" EXACT []
synonym: "upregulation of myoblast differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045661 ! regulation of myoblast differentiation
relationship: positively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045664
name: regulation of neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045665
name: negative regulation of neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "down regulation of neuron differentiation" EXACT []
synonym: "down-regulation of neuron differentiation" EXACT []
synonym: "downregulation of neuron differentiation" EXACT []
synonym: "inhibition of neuron differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: negatively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045666
name: positive regulation of neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "activation of neuron differentiation" NARROW []
synonym: "stimulation of neuron differentiation" NARROW []
synonym: "up regulation of neuron differentiation" EXACT []
synonym: "up-regulation of neuron differentiation" EXACT []
synonym: "upregulation of neuron differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: positively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045667
name: regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045668
name: negative regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
synonym: "down regulation of osteoblast differentiation" EXACT []
synonym: "down-regulation of osteoblast differentiation" EXACT []
synonym: "downregulation of osteoblast differentiation" EXACT []
synonym: "inhibition of osteoblast differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045667 ! regulation of osteoblast differentiation
relationship: negatively_regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045669
name: positive regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
synonym: "activation of osteoblast differentiation" NARROW []
synonym: "stimulation of osteoblast differentiation" NARROW []
synonym: "up regulation of osteoblast differentiation" EXACT []
synonym: "up-regulation of osteoblast differentiation" EXACT []
synonym: "upregulation of osteoblast differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045667 ! regulation of osteoblast differentiation
relationship: positively_regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045670
name: regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045671
name: negative regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "down regulation of osteoclast differentiation" EXACT []
synonym: "down-regulation of osteoclast differentiation" EXACT []
synonym: "downregulation of osteoclast differentiation" EXACT []
synonym: "inhibition of osteoclast differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
relationship: negatively_regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045672
name: positive regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "activation of osteoclast differentiation" NARROW []
synonym: "stimulation of osteoclast differentiation" NARROW []
synonym: "up regulation of osteoclast differentiation" EXACT []
synonym: "up-regulation of osteoclast differentiation" EXACT []
synonym: "upregulation of osteoclast differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
relationship: positively_regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045676
name: regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
relationship: regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045677
name: negative regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of R7 differentiation" EXACT []
synonym: "down-regulation of R7 differentiation" EXACT []
synonym: "downregulation of R7 differentiation" EXACT []
synonym: "inhibition of R7 differentiation" NARROW []
synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045676 ! regulation of R7 cell differentiation
is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation
relationship: negatively_regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045678
name: positive regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R7 differentiation" NARROW []
synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R7 differentiation" NARROW []
synonym: "up regulation of R7 differentiation" EXACT []
synonym: "up-regulation of R7 differentiation" EXACT []
synonym: "upregulation of R7 differentiation" EXACT []
is_a: GO:0045676 ! regulation of R7 cell differentiation
is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation
relationship: positively_regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045679
name: regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators]
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
relationship: regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045680
name: negative regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of R8 differentiation" EXACT []
synonym: "down-regulation of R8 differentiation" EXACT []
synonym: "downregulation of R8 differentiation" EXACT []
synonym: "inhibition of R8 differentiation" NARROW []
synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045679 ! regulation of R8 cell differentiation
is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation
relationship: negatively_regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045681
name: positive regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R8 differentiation" NARROW []
synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R8 differentiation" NARROW []
synonym: "up regulation of R8 differentiation" EXACT []
synonym: "up-regulation of R8 differentiation" EXACT []
synonym: "upregulation of R8 differentiation" EXACT []
is_a: GO:0045679 ! regulation of R8 cell differentiation
is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation
relationship: positively_regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045682
name: regulation of epidermis development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "regulation of epidermal development" EXACT []
synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045683
name: negative regulation of epidermis development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "down regulation of epidermis development" EXACT []
synonym: "down-regulation of epidermis development" EXACT []
synonym: "downregulation of epidermis development" EXACT []
synonym: "inhibition of epidermis development" NARROW []
synonym: "negative regulation of epidermal development" EXACT []
synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045684
name: positive regulation of epidermis development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "activation of epidermis development" NARROW []
synonym: "positive regulation of epidermal development" EXACT []
synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermis development" NARROW []
synonym: "up regulation of epidermis development" EXACT []
synonym: "up-regulation of epidermis development" EXACT []
synonym: "upregulation of epidermis development" EXACT []
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045685
name: regulation of glial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "regulation of glia cell differentiation" EXACT []
synonym: "regulation of neuroglia differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045686
name: negative regulation of glial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "down regulation of glial cell differentiation" EXACT []
synonym: "down-regulation of glial cell differentiation" EXACT []
synonym: "downregulation of glial cell differentiation" EXACT []
synonym: "inhibition of glial cell differentiation" NARROW []
synonym: "negative regulation of glia cell differentiation" EXACT []
synonym: "negative regulation of neuroglia differentiation" EXACT []
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: negatively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045687
name: positive regulation of glial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "activation of glial cell differentiation" NARROW []
synonym: "positive regulation of glia cell differentiation" EXACT []
synonym: "positive regulation of neuroglia differentiation" EXACT []
synonym: "stimulation of glial cell differentiation" NARROW []
synonym: "up regulation of glial cell differentiation" EXACT []
synonym: "up-regulation of glial cell differentiation" EXACT []
synonym: "upregulation of glial cell differentiation" EXACT []
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: positively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045688
name: regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045689
name: negative regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of antipodal cell differentiation" EXACT []
synonym: "down-regulation of antipodal cell differentiation" EXACT []
synonym: "downregulation of antipodal cell differentiation" EXACT []
synonym: "inhibition of antipodal cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045688 ! regulation of antipodal cell differentiation
relationship: negatively_regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045690
name: positive regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of antipodal cell differentiation" NARROW []
synonym: "stimulation of antipodal cell differentiation" NARROW []
synonym: "up regulation of antipodal cell differentiation" EXACT []
synonym: "up-regulation of antipodal cell differentiation" EXACT []
synonym: "upregulation of antipodal cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045688 ! regulation of antipodal cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045691
name: regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "regulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045692
name: negative regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of female gametophyte central cell differentiation" EXACT []
synonym: "down-regulation of female gametophyte central cell differentiation" EXACT []
synonym: "downregulation of female gametophyte central cell differentiation" EXACT []
synonym: "inhibition of female gametophyte central cell differentiation" NARROW []
synonym: "negative regulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045691 ! regulation of embryo sac central cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045693
name: positive regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of female gametophyte central cell differentiation" NARROW []
synonym: "positive regulation of female gametophyte central cell differentiation" EXACT []
synonym: "stimulation of female gametophyte central cell differentiation" NARROW []
synonym: "up regulation of female gametophyte central cell differentiation" EXACT []
synonym: "up-regulation of female gametophyte central cell differentiation" EXACT []
synonym: "upregulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045691 ! regulation of embryo sac central cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045694
name: regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "regulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045695
name: negative regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "down-regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "downregulation of female gametophyte egg cell differentiation" EXACT []
synonym: "inhibition of female gametophyte egg cell differentiation" NARROW []
synonym: "negative regulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045696
name: positive regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of female gametophyte egg cell differentiation" NARROW []
synonym: "positive regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "stimulation of female gametophyte egg cell differentiation" NARROW []
synonym: "up regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "up-regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "upregulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045697
name: regulation of synergid differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "regulation of synergid cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045698
name: negative regulation of synergid differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "down regulation of synergid differentiation" EXACT []
synonym: "down-regulation of synergid differentiation" EXACT []
synonym: "downregulation of synergid differentiation" EXACT []
synonym: "inhibition of synergid differentiation" NARROW []
synonym: "negative regulation of synergid cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045697 ! regulation of synergid differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045699
name: positive regulation of synergid differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "activation of synergid differentiation" NARROW []
synonym: "positive regulation of synergid cell differentiation" EXACT []
synonym: "stimulation of synergid differentiation" NARROW []
synonym: "up regulation of synergid differentiation" EXACT []
synonym: "up-regulation of synergid differentiation" EXACT []
synonym: "upregulation of synergid differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045697 ! regulation of synergid differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045700
name: regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:1903353 ! regulation of nucleus organization
relationship: regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045701
name: negative regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "down regulation of spermatid nuclear differentiation" EXACT []
synonym: "down-regulation of spermatid nuclear differentiation" EXACT []
synonym: "downregulation of spermatid nuclear differentiation" EXACT []
synonym: "inhibition of spermatid nuclear differentiation" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045702
name: positive regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "activation of spermatid nuclear differentiation" NARROW []
synonym: "stimulation of spermatid nuclear differentiation" NARROW []
synonym: "up regulation of spermatid nuclear differentiation" EXACT []
synonym: "up-regulation of spermatid nuclear differentiation" EXACT []
synonym: "upregulation of spermatid nuclear differentiation" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045703
name: ketoreductase activity
namespace: molecular_function
def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [GOC:curators]
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0045704
name: regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "regulation of salivary gland determination" EXACT [GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045705
name: negative regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "down regulation of salivary gland determination" EXACT []
synonym: "down-regulation of salivary gland determination" EXACT []
synonym: "downregulation of salivary gland determination" EXACT []
synonym: "inhibition of salivary gland determination" NARROW []
synonym: "negative regulation of salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045706
name: positive regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "activation of salivary gland determination" NARROW []
synonym: "positive regulation of salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of salivary gland determination" NARROW []
synonym: "up regulation of salivary gland determination" EXACT []
synonym: "up-regulation of salivary gland determination" EXACT []
synonym: "upregulation of salivary gland determination" EXACT []
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045707
name: regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "regulation of adult salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
relationship: regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045708
name: regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "regulation of larval salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
relationship: regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045709
name: negative regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "down regulation of adult salivary gland determination" EXACT []
synonym: "down-regulation of adult salivary gland determination" EXACT []
synonym: "downregulation of adult salivary gland determination" EXACT []
synonym: "inhibition of adult salivary gland determination" NARROW []
synonym: "negative regulation of adult salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045705 ! negative regulation of salivary gland boundary specification
is_a: GO:0045707 ! regulation of adult salivary gland boundary specification
relationship: negatively_regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045710
name: negative regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "down regulation of larval salivary gland determination" EXACT []
synonym: "down-regulation of larval salivary gland determination" EXACT []
synonym: "downregulation of larval salivary gland determination" EXACT []
synonym: "inhibition of larval salivary gland determination" NARROW []
synonym: "negative regulation of larval salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045705 ! negative regulation of salivary gland boundary specification
is_a: GO:0045708 ! regulation of larval salivary gland boundary specification
relationship: negatively_regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045711
name: positive regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "activation of adult salivary gland determination" NARROW []
synonym: "positive regulation of adult salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of adult salivary gland determination" NARROW []
synonym: "up regulation of adult salivary gland determination" EXACT []
synonym: "up-regulation of adult salivary gland determination" EXACT []
synonym: "upregulation of adult salivary gland determination" EXACT []
is_a: GO:0045706 ! positive regulation of salivary gland boundary specification
is_a: GO:0045707 ! regulation of adult salivary gland boundary specification
relationship: positively_regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045712
name: positive regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "activation of larval salivary gland determination" NARROW []
synonym: "positive regulation of larval salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of larval salivary gland determination" NARROW []
synonym: "up regulation of larval salivary gland determination" EXACT []
synonym: "up-regulation of larval salivary gland determination" EXACT []
synonym: "upregulation of larval salivary gland determination" EXACT []
is_a: GO:0045706 ! positive regulation of salivary gland boundary specification
is_a: GO:0045708 ! regulation of larval salivary gland boundary specification
relationship: positively_regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045713
name: obsolete low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "LDLr biosynthesis" EXACT []
synonym: "LDLr biosynthetic process" EXACT []
synonym: "low-density lipoprotein receptor anabolism" EXACT []
synonym: "low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "low-density lipoprotein receptor formation" EXACT []
synonym: "low-density lipoprotein receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045714
name: obsolete regulation of low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "regulation of LDLr biosynthesis" EXACT []
synonym: "regulation of LDLr biosynthetic process" EXACT []
synonym: "regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "regulation of low-density lipoprotein receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045715
name: obsolete negative regulation of low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "down regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "down-regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "downregulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "inhibition of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "negative regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "negative regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0045716
name: obsolete positive regulation of low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "activation of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "positive regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "positive regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor synthesis" EXACT []
synonym: "stimulation of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "up regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "up-regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "upregulation of low-density lipoprotein receptor biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0045717
name: negative regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators]
synonym: "down regulation of fatty acid biosynthetic process" EXACT []
synonym: "down-regulation of fatty acid biosynthetic process" EXACT []
synonym: "downregulation of fatty acid biosynthetic process" EXACT []
synonym: "inhibition of fatty acid biosynthetic process" NARROW []
synonym: "negative regulation of fatty acid anabolism" EXACT []
synonym: "negative regulation of fatty acid biosynthesis" EXACT []
synonym: "negative regulation of fatty acid formation" EXACT []
synonym: "negative regulation of fatty acid synthesis" EXACT []
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0045718
name: obsolete negative regulation of flagellum assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "down regulation of flagellum assembly" EXACT []
synonym: "down-regulation of flagellum assembly" EXACT []
synonym: "downregulation of flagellum assembly" EXACT []
synonym: "inhibition of flagellum assembly" NARROW []
synonym: "negative regulation of flagella assembly" EXACT []
synonym: "negative regulation of flagellum assembly" EXACT []
synonym: "negative regulation of flagellum biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:1902018

[Term]
id: GO:0045719
name: negative regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
synonym: "down regulation of glycogen biosynthetic process" EXACT []
synonym: "down-regulation of glycogen biosynthetic process" EXACT []
synonym: "downregulation of glycogen biosynthetic process" EXACT []
synonym: "inhibition of glycogen biosynthetic process" NARROW []
synonym: "negative regulation of glycogen anabolism" EXACT []
synonym: "negative regulation of glycogen biosynthesis" EXACT []
synonym: "negative regulation of glycogen formation" EXACT []
synonym: "negative regulation of glycogen synthesis" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045720
name: negative regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "down regulation of integrin biosynthetic process" EXACT []
synonym: "down-regulation of integrin biosynthetic process" EXACT []
synonym: "downregulation of integrin biosynthetic process" EXACT []
synonym: "inhibition of integrin biosynthetic process" NARROW []
synonym: "negative regulation of integrin anabolism" EXACT []
synonym: "negative regulation of integrin biosynthesis" EXACT []
synonym: "negative regulation of integrin formation" EXACT []
synonym: "negative regulation of integrin synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045113 ! regulation of integrin biosynthetic process
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045721
name: negative regulation of gluconeogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
synonym: "down regulation of gluconeogenesis" EXACT []
synonym: "down-regulation of gluconeogenesis" EXACT []
synonym: "downregulation of gluconeogenesis" EXACT []
synonym: "inhibition of gluconeogenesis" NARROW []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045722
name: positive regulation of gluconeogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
synonym: "activation of gluconeogenesis" NARROW []
synonym: "stimulation of gluconeogenesis" NARROW []
synonym: "up regulation of gluconeogenesis" EXACT []
synonym: "up-regulation of gluconeogenesis" EXACT []
synonym: "upregulation of gluconeogenesis" EXACT []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010907 ! positive regulation of glucose metabolic process
relationship: positively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045723
name: positive regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators]
synonym: "activation of fatty acid biosynthetic process" NARROW []
synonym: "positive regulation of fatty acid anabolism" EXACT []
synonym: "positive regulation of fatty acid biosynthesis" EXACT []
synonym: "positive regulation of fatty acid formation" EXACT []
synonym: "positive regulation of fatty acid synthesis" EXACT []
synonym: "stimulation of fatty acid biosynthetic process" NARROW []
synonym: "up regulation of fatty acid biosynthetic process" EXACT []
synonym: "up-regulation of fatty acid biosynthetic process" EXACT []
synonym: "upregulation of fatty acid biosynthetic process" EXACT []
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
relationship: positively_regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0045724
name: positive regulation of cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]
synonym: "activation of cilium assembly" NARROW []
synonym: "positive regulation of flagellum assembly" BROAD []
synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cilium assembly" NARROW []
synonym: "up regulation of cilium assembly" EXACT []
synonym: "up-regulation of cilium assembly" EXACT []
synonym: "upregulation of cilium assembly" EXACT []
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0060271 ! cilium assembly

[Term]
id: GO:0045725
name: positive regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
synonym: "activation of glycogen biosynthetic process" NARROW []
synonym: "positive regulation of glycogen anabolism" EXACT []
synonym: "positive regulation of glycogen biosynthesis" EXACT []
synonym: "positive regulation of glycogen formation" EXACT []
synonym: "positive regulation of glycogen synthesis" EXACT []
synonym: "stimulation of glycogen biosynthetic process" NARROW []
synonym: "up regulation of glycogen biosynthetic process" EXACT []
synonym: "up-regulation of glycogen biosynthetic process" EXACT []
synonym: "upregulation of glycogen biosynthetic process" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045726
name: positive regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "activation of integrin biosynthetic process" NARROW []
synonym: "positive regulation of integrin anabolism" EXACT []
synonym: "positive regulation of integrin biosynthesis" EXACT []
synonym: "positive regulation of integrin formation" EXACT []
synonym: "positive regulation of integrin synthesis" EXACT []
synonym: "stimulation of integrin biosynthetic process" NARROW []
synonym: "up regulation of integrin biosynthetic process" EXACT []
synonym: "up-regulation of integrin biosynthetic process" EXACT []
synonym: "upregulation of integrin biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045113 ! regulation of integrin biosynthetic process
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045727
name: positive regulation of translation
namespace: biological_process
alt_id: GO:0045946
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of protein biosynthetic process" NARROW []
synonym: "positive regulation of protein anabolism" EXACT []
synonym: "positive regulation of protein biosynthesis" EXACT []
synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb]
synonym: "positive regulation of protein formation" EXACT []
synonym: "positive regulation of protein synthesis" EXACT []
synonym: "stimulation of protein biosynthetic process" NARROW []
synonym: "up regulation of protein biosynthetic process" EXACT []
synonym: "up-regulation of protein biosynthetic process" EXACT []
synonym: "upregulation of protein biosynthetic process" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0006412 ! translation

[Term]
id: GO:0045728
name: respiratory burst after phagocytosis
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." [GOC:curators, ISBN:0198506732]
synonym: "metabolic burst after phagocytosis" EXACT []
synonym: "oxidative burst after phagocytosis" EXACT []
is_a: GO:0002679 ! respiratory burst involved in defense response

[Term]
id: GO:0045729
name: respiratory burst at fertilization
namespace: biological_process
def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [ISBN:0198506732, PMID:2537493, PMID:9013127]
synonym: "metabolic burst at fertilization" EXACT []
synonym: "oxidative burst at fertilization" EXACT []
is_a: GO:0045730 ! respiratory burst
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0045730
name: respiratory burst
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732]
synonym: "metabolic burst" EXACT []
synonym: "oxidative burst" EXACT []
xref: Wikipedia:Respiratory_burst
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0045732
name: positive regulation of protein catabolic process
namespace: biological_process
alt_id: GO:1903364
alt_id: GO:2000600
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of protein catabolic process" NARROW []
synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolic process" EXACT []
synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol]
synonym: "positive regulation of cyclin catabolic process" NARROW []
synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol]
synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol]
synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol]
synonym: "positive regulation of protein breakdown" EXACT []
synonym: "positive regulation of protein catabolism" EXACT []
synonym: "positive regulation of protein degradation" EXACT []
synonym: "stimulation of protein catabolic process" NARROW []
synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein catabolic process" EXACT []
synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein catabolic process" EXACT []
synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0045733
name: acetate catabolic process
namespace: biological_process
alt_id: GO:0019663
def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "acetate breakdown" EXACT []
synonym: "acetate catabolism" EXACT []
synonym: "acetate degradation" EXACT []
synonym: "homoacetate catabolic process" RELATED []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0045734
name: regulation of acetate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "regulation of acetate breakdown" EXACT []
synonym: "regulation of acetate catabolism" EXACT []
synonym: "regulation of acetate degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045735
name: nutrient reservoir activity
namespace: molecular_function
def: "Functions in the storage of nutritious substrates." [GOC:ai]
comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'.
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
synonym: "storage protein" RELATED []
synonym: "storage protein of fat body" RELATED []
synonym: "yolk protein" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045736
name: negative regulation of cyclin-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
subset: gocheck_obsoletion_candidate
is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
is_a: GO:1904030 ! negative regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0045737
name: positive regulation of cyclin-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr]
subset: gocheck_obsoletion_candidate
synonym: "activation of cyclin-dependent protein kinase activity" BROAD []
synonym: "positive regulation of CDK activity" BROAD []
synonym: "positive regulation of cyclin-dependent protein kinase activity" BROAD [GOC:pr]
synonym: "stimulation of cyclin-dependent protein kinase activity" BROAD []
synonym: "up regulation of cyclin-dependent protein kinase activity" BROAD []
synonym: "up-regulation of cyclin-dependent protein kinase activity" BROAD []
synonym: "upregulation of cyclin-dependent protein kinase activity" BROAD []
is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:1904031 ! positive regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0045738
name: negative regulation of DNA repair
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair." [GOC:go_curators]
synonym: "down regulation of DNA repair" EXACT []
synonym: "down-regulation of DNA repair" EXACT []
synonym: "downregulation of DNA repair" EXACT []
synonym: "inhibition of DNA repair" NARROW []
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0006281 ! DNA repair

[Term]
id: GO:0045739
name: positive regulation of DNA repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]
synonym: "activation of DNA repair" NARROW []
synonym: "stimulation of DNA repair" NARROW []
synonym: "up regulation of DNA repair" EXACT []
synonym: "up-regulation of DNA repair" EXACT []
synonym: "upregulation of DNA repair" EXACT []
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0006281 ! DNA repair

[Term]
id: GO:0045740
name: positive regulation of DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators]
synonym: "activation of DNA replication" NARROW []
synonym: "stimulation of DNA replication" NARROW []
synonym: "up regulation of DNA replication" EXACT []
synonym: "up-regulation of DNA replication" EXACT []
synonym: "upregulation of DNA replication" EXACT []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0006260 ! DNA replication

[Term]
id: GO:0045741
name: positive regulation of epidermal growth factor-activated receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "activation of epidermal growth factor receptor activity" NARROW []
synonym: "positive regulation of EGF receptor activity" EXACT []
synonym: "positive regulation of EGFR activity" EXACT []
synonym: "positive regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "stimulation of epidermal growth factor receptor activity" NARROW []
synonym: "up regulation of epidermal growth factor receptor activity" EXACT []
synonym: "up-regulation of epidermal growth factor receptor activity" EXACT []
synonym: "upregulation of epidermal growth factor receptor activity" EXACT []
is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity
is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity
is_a: GO:2000273 ! positive regulation of signaling receptor activity

[Term]
id: GO:0045742
name: positive regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of EGF receptor signaling pathway" EXACT []
synonym: "positive regulation of EGF receptor signalling pathway" EXACT []
synonym: "positive regulation of EGFR signaling pathway" EXACT []
synonym: "stimulation of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of epidermal growth factor receptor signaling pathway" EXACT []
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:1901186 ! positive regulation of ERBB signaling pathway
relationship: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0045743
name: positive regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of FGF receptor signaling pathway" EXACT []
synonym: "positive regulation of FGF receptor signalling pathway" EXACT []
synonym: "positive regulation of FGFR signaling pathway" EXACT []
synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0045744
name: negative regulation of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]
synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of GPCR protein signaling pathway" EXACT []
synonym: "negative regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0045745
name: positive regulation of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of GPCR protein signaling pathway" EXACT []
synonym: "positive regulation of GPCR protein signalling pathway" EXACT []
synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0045746
name: negative regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "down regulation of Notch signaling pathway" EXACT []
synonym: "down-regulation of Notch signaling pathway" EXACT []
synonym: "downregulation of Notch signaling pathway" EXACT []
synonym: "inhibition of Notch signaling pathway" NARROW []
synonym: "negative regulation of N signaling pathway" EXACT []
synonym: "negative regulation of N signalling pathway" EXACT []
synonym: "negative regulation of Notch signalling pathway" EXACT []
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0045747
name: positive regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "activation of Notch signaling pathway" NARROW []
synonym: "positive regulation of N signaling pathway" EXACT []
synonym: "positive regulation of N signalling pathway" EXACT []
synonym: "positive regulation of Notch signalling pathway" EXACT []
synonym: "stimulation of Notch signaling pathway" NARROW []
synonym: "up regulation of Notch signaling pathway" EXACT []
synonym: "up-regulation of Notch signaling pathway" EXACT []
synonym: "upregulation of Notch signaling pathway" EXACT []
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0045748
name: positive regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that activates or enforces the correct R8 cell spacing in a compound eye." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R8 spacing" NARROW []
synonym: "positive regulation of R8 spacing" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R8 spacing" NARROW []
synonym: "up regulation of R8 spacing" EXACT []
synonym: "up-regulation of R8 spacing" EXACT []
synonym: "upregulation of R8 spacing" EXACT []
is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye

[Term]
id: GO:0045749
name: obsolete negative regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "down regulation of S phase of mitotic cell cycle" EXACT []
synonym: "down-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "downregulation of S phase of mitotic cell cycle" EXACT []
synonym: "inhibition of S phase of mitotic cell cycle" NARROW []
synonym: "negative regulation of S phase of mitotic cell cycle" EXACT []
synonym: "negative regulation of S-phase of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0045750
name: obsolete positive regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "activation of S phase of mitotic cell cycle" NARROW []
synonym: "positive regulation of S phase of mitotic cell cycle" EXACT []
synonym: "positive regulation of S-phase of mitotic cell cycle" EXACT []
synonym: "stimulation of S phase of mitotic cell cycle" NARROW []
synonym: "up regulation of S phase of mitotic cell cycle" EXACT []
synonym: "up-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "upregulation of S phase of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0045751
name: negative regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "down regulation of Toll signaling pathway" EXACT []
synonym: "down-regulation of Toll signaling pathway" EXACT []
synonym: "downregulation of Toll signaling pathway" EXACT []
synonym: "inhibition of Toll signaling pathway" NARROW []
synonym: "negative regulation of Tl signaling pathway" EXACT []
synonym: "negative regulation of Tl signalling pathway" EXACT []
is_a: GO:0008592 ! regulation of Toll signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0045752
name: positive regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "activation of Toll signaling pathway" NARROW []
synonym: "positive regulation of Tl signaling pathway" EXACT []
synonym: "positive regulation of Tl signalling pathway" EXACT []
synonym: "stimulation of Toll signaling pathway" NARROW []
synonym: "up regulation of Toll signaling pathway" EXACT []
synonym: "up-regulation of Toll signaling pathway" EXACT []
synonym: "upregulation of Toll signaling pathway" EXACT []
is_a: GO:0008592 ! regulation of Toll signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0045753
name: negative regulation of acetate catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
synonym: "down regulation of acetate catabolic process" EXACT []
synonym: "down-regulation of acetate catabolic process" EXACT []
synonym: "downregulation of acetate catabolic process" EXACT []
synonym: "inhibition of acetate catabolic process" NARROW []
synonym: "negative regulation of acetate breakdown" EXACT []
synonym: "negative regulation of acetate catabolism" EXACT []
synonym: "negative regulation of acetate degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045754
name: positive regulation of acetate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
synonym: "activation of acetate catabolic process" NARROW []
synonym: "positive regulation of acetate breakdown" EXACT []
synonym: "positive regulation of acetate catabolism" EXACT []
synonym: "positive regulation of acetate degradation" EXACT []
synonym: "stimulation of acetate catabolic process" NARROW []
synonym: "up regulation of acetate catabolic process" EXACT []
synonym: "up-regulation of acetate catabolic process" EXACT []
synonym: "upregulation of acetate catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045755
name: negative regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
synonym: "down regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "down-regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "downregulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "inhibition of initiation of acetate catabolic process by acetate" NARROW []
synonym: "negative regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "negative regulation of initiation of acetate degradation by acetate" EXACT []
is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate
is_a: GO:1901458 ! negative regulation of response to acetate
relationship: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045756
name: positive regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
synonym: "activation of initiation of acetate catabolic process by acetate" NARROW []
synonym: "positive regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "positive regulation of initiation of acetate degradation by acetate" EXACT []
synonym: "stimulation of initiation of acetate catabolic process by acetate" NARROW []
synonym: "up regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "up-regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "upregulation of initiation of acetate catabolic process by acetate" EXACT []
is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate
is_a: GO:0045754 ! positive regulation of acetate catabolic process
is_a: GO:1901459 ! positive regulation of response to acetate
relationship: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045757
name: obsolete negative regulation of actin polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "negative regulation of actin polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030835
consider: GO:0030837

[Term]
id: GO:0045758
name: obsolete positive regulation of actin polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "positive regulation of actin polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030836
consider: GO:0030838

[Term]
id: GO:0045759
name: negative regulation of action potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "down regulation of action potential" EXACT []
synonym: "down-regulation of action potential" EXACT []
synonym: "downregulation of action potential" EXACT []
synonym: "inhibition of action potential" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0098900 ! regulation of action potential
relationship: negatively_regulates GO:0001508 ! action potential

[Term]
id: GO:0045760
name: positive regulation of action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "activation of action potential" NARROW []
synonym: "stimulation of action potential" NARROW []
synonym: "up regulation of action potential" EXACT []
synonym: "up-regulation of action potential" EXACT []
synonym: "upregulation of action potential" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0098900 ! regulation of action potential
relationship: positively_regulates GO:0001508 ! action potential

[Term]
id: GO:0045761
name: regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "adenylate cyclase regulator" RELATED []
synonym: "regulation of adenylyl cyclase activity" EXACT []
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0045762
name: positive regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "adenylate cyclase activator" RELATED []
synonym: "positive regulation of adenylyl cyclase activity" EXACT []
synonym: "stimulation of adenylate cyclase activity" NARROW []
synonym: "up regulation of adenylate cyclase activity" EXACT []
synonym: "up-regulation of adenylate cyclase activity" EXACT []
synonym: "upregulation of adenylate cyclase activity" EXACT []
is_a: GO:0031281 ! positive regulation of cyclase activity
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0051349 ! positive regulation of lyase activity

[Term]
id: GO:0045763
name: negative regulation of amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
synonym: "down regulation of amino acid metabolic process" EXACT []
synonym: "down-regulation of amino acid metabolic process" EXACT []
synonym: "downregulation of amino acid metabolic process" EXACT []
synonym: "inhibition of amino acid metabolic process" NARROW []
synonym: "negative regulation of amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009892 ! negative regulation of metabolic process
relationship: negatively_regulates GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0045764
name: positive regulation of amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
synonym: "activation of amino acid metabolic process" NARROW []
synonym: "positive regulation of amino acid metabolism" EXACT []
synonym: "positive regulation of cellular amino acid metabolic process" EXACT []
synonym: "stimulation of amino acid metabolic process" NARROW []
synonym: "up regulation of amino acid metabolic process" EXACT []
synonym: "up-regulation of amino acid metabolic process" EXACT []
synonym: "upregulation of amino acid metabolic process" EXACT []
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
relationship: positively_regulates GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0045765
name: regulation of angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development
relationship: regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045766
name: positive regulation of angiogenesis
namespace: biological_process
def: "Any process that activates or increases angiogenesis." [GOC:go_curators]
synonym: "activation of angiogenesis" NARROW []
synonym: "stimulation of angiogenesis" NARROW []
synonym: "up regulation of angiogenesis" EXACT []
synonym: "up-regulation of angiogenesis" EXACT []
synonym: "upregulation of angiogenesis" EXACT []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:1904018 ! positive regulation of vasculature development
relationship: positively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045767
name: obsolete regulation of anti-apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis]
comment: This term was made obsolete because it was ill-defined.
synonym: "regulation of anti-apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0045768
name: obsolete positive regulation of anti-apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis]
comment: This term was made obsolete because it was ill-defined.
synonym: "activation of anti-apoptosis" NARROW []
synonym: "positive regulation of anti-apoptosis" EXACT []
synonym: "stimulation of anti-apoptosis" NARROW []
synonym: "up regulation of anti-apoptosis" EXACT []
synonym: "up-regulation of anti-apoptosis" EXACT []
synonym: "upregulation of anti-apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0045769
name: negative regulation of asymmetric cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "down regulation of asymmetric cell division" EXACT []
synonym: "down-regulation of asymmetric cell division" EXACT []
synonym: "downregulation of asymmetric cell division" EXACT []
synonym: "inhibition of asymmetric cell division" NARROW []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051782 ! negative regulation of cell division
relationship: negatively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045770
name: positive regulation of asymmetric cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "activation of asymmetric cell division" NARROW []
synonym: "stimulation of asymmetric cell division" NARROW []
synonym: "up regulation of asymmetric cell division" EXACT []
synonym: "up-regulation of asymmetric cell division" EXACT []
synonym: "upregulation of asymmetric cell division" EXACT []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051781 ! positive regulation of cell division
relationship: positively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045771
name: negative regulation of autophagosome size
namespace: biological_process
def: "Any process that reduces autophagosome size." [GOC:autophagy, GOC:go_curators]
synonym: "down regulation of autophagic vacuole size" EXACT []
synonym: "down-regulation of autophagic vacuole size" EXACT []
synonym: "downregulation of autophagic vacuole size" EXACT []
synonym: "inhibition of autophagic vacuole size" NARROW []
synonym: "negative regulation of autophagic vacuole size" EXACT [GOC:autophagy]
is_a: GO:0016243 ! regulation of autophagosome size

[Term]
id: GO:0045772
name: positive regulation of autophagosome size
namespace: biological_process
def: "Any process that increases autophagosome size." [GOC:autophagy, GOC:go_curators]
synonym: "activation of autophagic vacuole size" NARROW []
synonym: "positive regulation of autophagic vacuole size" EXACT [GOC:autophagy]
synonym: "stimulation of autophagic vacuole size" NARROW []
synonym: "up regulation of autophagic vacuole size" EXACT []
synonym: "up-regulation of autophagic vacuole size" EXACT []
synonym: "upregulation of autophagic vacuole size" EXACT []
is_a: GO:0016243 ! regulation of autophagosome size

[Term]
id: GO:0045773
name: positive regulation of axon extension
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators]
synonym: "activation of axon extension" NARROW []
synonym: "stimulation of axon extension" NARROW []
synonym: "up regulation of axon extension" EXACT []
synonym: "up-regulation of axon extension" EXACT []
synonym: "upregulation of axon extension" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0050772 ! positive regulation of axonogenesis
relationship: positively_regulates GO:0048675 ! axon extension

[Term]
id: GO:0045774
name: negative regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "down regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "down-regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "downregulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "inhibition of beta 2 integrin biosynthetic process" NARROW []
synonym: "negative regulation of beta 2 integrin anabolism" EXACT []
synonym: "negative regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "negative regulation of beta 2 integrin formation" EXACT []
synonym: "negative regulation of beta 2 integrin synthesis" EXACT []
is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process
is_a: GO:0045720 ! negative regulation of integrin biosynthetic process
relationship: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045775
name: positive regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "activation of beta 2 integrin biosynthetic process" NARROW []
synonym: "positive regulation of beta 2 integrin anabolism" EXACT []
synonym: "positive regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "positive regulation of beta 2 integrin formation" EXACT []
synonym: "positive regulation of beta 2 integrin synthesis" EXACT []
synonym: "stimulation of beta 2 integrin biosynthetic process" NARROW []
synonym: "up regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "up-regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "upregulation of beta 2 integrin biosynthetic process" EXACT []
is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process
is_a: GO:0045726 ! positive regulation of integrin biosynthetic process
relationship: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045776
name: negative regulation of blood pressure
namespace: biological_process
def: "Any process in which the force of blood traveling through the circulatory system is decreased." [GOC:go_curators, GOC:mtg_cardio]
synonym: "down regulation of blood pressure" EXACT []
synonym: "down-regulation of blood pressure" EXACT []
synonym: "downregulation of blood pressure" EXACT []
synonym: "inhibition of blood pressure" NARROW []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0045777
name: positive regulation of blood pressure
namespace: biological_process
def: "Any process in which the force of blood traveling through the circulatory system is increased." [GOC:go_curators, GOC:mtg_cardio]
synonym: "activation of blood pressure" NARROW []
synonym: "stimulation of blood pressure" NARROW []
synonym: "up regulation of blood pressure" EXACT []
synonym: "up-regulation of blood pressure" EXACT []
synonym: "upregulation of blood pressure" EXACT []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0045778
name: positive regulation of ossification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "activation of ossification" NARROW []
synonym: "positive regulation of bone biosynthesis" EXACT []
synonym: "positive regulation of bone formation" EXACT []
synonym: "stimulation of ossification" NARROW []
synonym: "up regulation of ossification" EXACT []
synonym: "up-regulation of ossification" EXACT []
synonym: "upregulation of ossification" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0001503 ! ossification

[Term]
id: GO:0045779
name: negative regulation of bone resorption
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "down regulation of bone resorption" EXACT []
synonym: "down-regulation of bone resorption" EXACT []
synonym: "downregulation of bone resorption" EXACT []
synonym: "inhibition of bone resorption" NARROW []
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0046851 ! negative regulation of bone remodeling
relationship: negatively_regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045780
name: positive regulation of bone resorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "activation of bone resorption" NARROW []
synonym: "stimulation of bone resorption" NARROW []
synonym: "up regulation of bone resorption" EXACT []
synonym: "up-regulation of bone resorption" EXACT []
synonym: "upregulation of bone resorption" EXACT []
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045781
name: negative regulation of cell budding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding." [GOC:go_curators]
synonym: "down regulation of cell budding" EXACT []
synonym: "down-regulation of cell budding" EXACT []
synonym: "downregulation of cell budding" EXACT []
synonym: "inhibition of cell budding" NARROW []
synonym: "negative regulation of budding" BROAD []
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0051782 ! negative regulation of cell division
is_a: GO:1903665 ! negative regulation of asexual reproduction
relationship: negatively_regulates GO:0007114 ! cell budding

[Term]
id: GO:0045782
name: positive regulation of cell budding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell budding." [GOC:go_curators]
synonym: "activation of cell budding" NARROW []
synonym: "positive regulation of budding" BROAD []
synonym: "stimulation of cell budding" NARROW []
synonym: "up regulation of cell budding" EXACT []
synonym: "up-regulation of cell budding" EXACT []
synonym: "upregulation of cell budding" EXACT []
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:1903666 ! positive regulation of asexual reproduction
relationship: positively_regulates GO:0007114 ! cell budding

[Term]
id: GO:0045783
name: obsolete negative regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that reduces the concentration of calcium in the ER." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
synonym: "negative regulation of calcium in ER" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0045784
name: obsolete positive regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that increases the concentration of calcium in the ER." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
synonym: "positive regulation of calcium in ER" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0045785
name: positive regulation of cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "activation of cell adhesion" NARROW []
synonym: "stimulation of cell adhesion" NARROW []
synonym: "up regulation of cell adhesion" EXACT []
synonym: "up-regulation of cell adhesion" EXACT []
synonym: "upregulation of cell adhesion" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0045786
name: negative regulation of cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through cell cycle" EXACT []
synonym: "down-regulation of progression through cell cycle" EXACT []
synonym: "downregulation of progression through cell cycle" EXACT []
synonym: "inhibition of progression through cell cycle" NARROW []
synonym: "negative regulation of cell cycle progression" EXACT []
synonym: "negative regulation of progression through cell cycle" EXACT []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
relationship: negatively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045787
name: positive regulation of cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
synonym: "activation of progression through cell cycle" NARROW []
synonym: "positive regulation of cell cycle progression" EXACT []
synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through cell cycle" NARROW []
synonym: "up regulation of progression through cell cycle" EXACT []
synonym: "up-regulation of progression through cell cycle" EXACT []
synonym: "upregulation of progression through cell cycle" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
relationship: positively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045792
name: negative regulation of cell size
namespace: biological_process
def: "Any process that reduces cell size." [GOC:go_curators]
synonym: "down regulation of cell size" EXACT []
synonym: "down-regulation of cell size" EXACT []
synonym: "downregulation of cell size" EXACT []
synonym: "inhibition of cell size" NARROW []
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0045793
name: positive regulation of cell size
namespace: biological_process
def: "Any process that increases cell size." [GOC:go_curators]
synonym: "activation of cell size" NARROW []
synonym: "stimulation of cell size" NARROW []
synonym: "up regulation of cell size" EXACT []
synonym: "up-regulation of cell size" EXACT []
synonym: "upregulation of cell size" EXACT []
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0045794
name: negative regulation of cell volume
namespace: biological_process
def: "Any process that decreases cell volume." [GOC:go_curators]
synonym: "cell regulatory volume decrease" RELATED [PMID:12388065]
synonym: "RVD" RELATED [PMID:12388065]
is_a: GO:0006884 ! cell volume homeostasis

[Term]
id: GO:0045795
name: positive regulation of cell volume
namespace: biological_process
def: "Any process that increases cell volume." [GOC:go_curators]
is_a: GO:0006884 ! cell volume homeostasis

[Term]
id: GO:0045796
name: negative regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators]
synonym: "down regulation of cholesterol absorption" EXACT []
synonym: "down-regulation of cholesterol absorption" EXACT []
synonym: "downregulation of cholesterol absorption" EXACT []
synonym: "inhibition of cholesterol absorption" NARROW []
is_a: GO:0030300 ! regulation of intestinal cholesterol absorption
is_a: GO:1904730 ! negative regulation of intestinal lipid absorption
relationship: negatively_regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0045797
name: positive regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators]
synonym: "activation of cholesterol absorption" NARROW []
synonym: "stimulation of cholesterol absorption" NARROW []
synonym: "up regulation of cholesterol absorption" EXACT []
synonym: "up-regulation of cholesterol absorption" EXACT []
synonym: "upregulation of cholesterol absorption" EXACT []
is_a: GO:0030300 ! regulation of intestinal cholesterol absorption
is_a: GO:1904731 ! positive regulation of intestinal lipid absorption
relationship: positively_regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0045800
name: negative regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu]
synonym: "down regulation of cuticle tanning" EXACT []
synonym: "down-regulation of cuticle tanning" EXACT []
synonym: "downregulation of cuticle tanning" EXACT []
synonym: "inhibition of cuticle tanning" NARROW []
synonym: "negative regulation of cuticle hardening" NARROW []
synonym: "negative regulation of cuticle tanning" EXACT []
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0045801
name: positive regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu]
synonym: "activation of cuticle tanning" NARROW []
synonym: "positive regulation of cuticle hardening" NARROW []
synonym: "positive regulation of cuticle tanning" EXACT []
synonym: "stimulation of cuticle tanning" NARROW []
synonym: "up regulation of cuticle tanning" EXACT []
synonym: "up-regulation of cuticle tanning" EXACT []
synonym: "upregulation of cuticle tanning" EXACT []
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0045802
name: obsolete negative regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense.
synonym: "negative regulation of cytoskeleton" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0045803
name: obsolete positive regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense.
synonym: "positive regulation of cytoskeleton" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0045804
name: negative regulation of eclosion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion." [GOC:go_curators]
synonym: "down regulation of eclosion" EXACT []
synonym: "down-regulation of eclosion" EXACT []
synonym: "downregulation of eclosion" EXACT []
synonym: "inhibition of eclosion" NARROW []
is_a: GO:0007563 ! regulation of eclosion
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007562 ! eclosion

[Term]
id: GO:0045805
name: positive regulation of eclosion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eclosion." [GOC:go_curators]
synonym: "activation of eclosion" NARROW []
synonym: "stimulation of eclosion" NARROW []
synonym: "up regulation of eclosion" EXACT []
synonym: "up-regulation of eclosion" EXACT []
synonym: "upregulation of eclosion" EXACT []
is_a: GO:0007563 ! regulation of eclosion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0007562 ! eclosion

[Term]
id: GO:0045806
name: negative regulation of endocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "down regulation of endocytosis" EXACT []
synonym: "down-regulation of endocytosis" EXACT []
synonym: "downregulation of endocytosis" EXACT []
synonym: "inhibition of endocytosis" NARROW []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045807
name: positive regulation of endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "activation of endocytosis" NARROW []
synonym: "stimulation of endocytosis" NARROW []
synonym: "up regulation of endocytosis" EXACT []
synonym: "up-regulation of endocytosis" EXACT []
synonym: "upregulation of endocytosis" EXACT []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045808
name: negative regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators]
synonym: "down regulation of establishment of competence for transformation" EXACT []
synonym: "down-regulation of establishment of competence for transformation" EXACT []
synonym: "downregulation of establishment of competence for transformation" EXACT []
synonym: "inhibition of establishment of competence for transformation" NARROW []
synonym: "inhibitor of the establishment of competence for transformation activity" RELATED []
is_a: GO:0045304 ! regulation of establishment of competence for transformation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045809
name: positive regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators]
synonym: "activation of establishment of competence for transformation" NARROW []
synonym: "activator of the establishment of competence for transformation activity" RELATED []
synonym: "stimulation of establishment of competence for transformation" NARROW []
synonym: "up regulation of establishment of competence for transformation" EXACT []
synonym: "up-regulation of establishment of competence for transformation" EXACT []
synonym: "upregulation of establishment of competence for transformation" EXACT []
is_a: GO:0045304 ! regulation of establishment of competence for transformation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045812
name: negative regulation of Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of frizzled-2 signaling pathway" EXACT []
synonym: "down-regulation of frizzled-2 signaling pathway" EXACT []
synonym: "downregulation of frizzled-2 signaling pathway" EXACT []
synonym: "inhibition of frizzled-2 signaling pathway" NARROW []
synonym: "negative regulation of frizzled-2 signaling pathway" EXACT []
synonym: "negative regulation of frizzled-2 signalling pathway" EXACT []
synonym: "negative regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "negative regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
relationship: negatively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway

[Term]
id: GO:0045813
name: positive regulation of Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:go_curators]
synonym: "activation of frizzled-2 signaling pathway" NARROW []
synonym: "positive regulation of frizzled-2 signaling pathway" EXACT []
synonym: "positive regulation of frizzled-2 signalling pathway" EXACT []
synonym: "positive regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "positive regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
synonym: "stimulation of frizzled-2 signaling pathway" NARROW []
synonym: "up regulation of frizzled-2 signaling pathway" EXACT []
synonym: "up-regulation of frizzled-2 signaling pathway" EXACT []
synonym: "upregulation of frizzled-2 signaling pathway" EXACT []
is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway
is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway
relationship: positively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway

[Term]
id: GO:0045814
name: negative regulation of gene expression, epigenetic
namespace: biological_process
def: "An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]
synonym: "down regulation of gene expression, epigenetic" EXACT []
synonym: "down-regulation of gene expression, epigenetic" EXACT []
synonym: "downregulation of gene expression, epigenetic" EXACT []
synonym: "gene silencing" RELATED []
synonym: "inhibition of gene expression, epigenetic" NARROW []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0040029 ! epigenetic regulation of gene expression

[Term]
id: GO:0045815
name: transcription initiation-coupled chromatin remodeling
namespace: biological_process
alt_id: GO:0048096
def: "An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA." [PMID:34414474]
comment: This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. Do not confuse with GO:0140673 ; transcriptional elongation-coupled chromatin remodeling, which describes the reforming of chromatin after RNA polymerase II passage.
synonym: "chromatin-mediated maintenance of transcription" EXACT []
synonym: "DNA replication-independent chromatin organization" RELATED []
synonym: "epigenetic maintenance of chromatin in transcription-competent conformation" EXACT []
synonym: "euchromatin assembly" RELATED []
synonym: "euchromatin organisation" RELATED []
synonym: "euchromatin organization" RELATED []
synonym: "long-term maintenance of gene activation" RELATED []
synonym: "maintenance of chromatin in transcription-competent conformation" EXACT []
synonym: "transciptional initiation-coupled chromatin remodeling" EXACT []
synonym: "transciptional initiation-coupled chromatin remodelling" EXACT []
synonym: "transcription initiation coupled chromatin remodeling" EXACT []
synonym: "transcription initiation coupled chromatin remodelling" EXACT []
synonym: "transcriptional initiation-coupled chromatin remodeling" EXACT []
synonym: "transcriptional initiation-coupled chromatin remodelling" EXACT []
is_a: GO:0141137 ! positive regulation of gene expression, epigenetic
relationship: part_of GO:0006367 ! transcription initiation at RNA polymerase II promoter

[Term]
id: GO:0045818
name: negative regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
synonym: "down regulation of glycogen catabolic process" EXACT []
synonym: "down-regulation of glycogen catabolic process" EXACT []
synonym: "downregulation of glycogen catabolic process" EXACT []
synonym: "inhibition of glycogen catabolic process" NARROW []
synonym: "negative regulation of glycogen breakdown" EXACT []
synonym: "negative regulation of glycogen catabolism" EXACT []
synonym: "negative regulation of glycogen degradation" EXACT []
synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl]
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
relationship: negatively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045819
name: positive regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
synonym: "activation of glycogen catabolic process" NARROW []
synonym: "positive regulation of glycogen breakdown" EXACT []
synonym: "positive regulation of glycogen catabolism" EXACT []
synonym: "positive regulation of glycogen degradation" EXACT []
synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl]
synonym: "stimulation of glycogen catabolic process" NARROW []
synonym: "up regulation of glycogen catabolic process" EXACT []
synonym: "up-regulation of glycogen catabolic process" EXACT []
synonym: "upregulation of glycogen catabolic process" EXACT []
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
relationship: positively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045820
name: negative regulation of glycolytic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators]
synonym: "down regulation of glycolysis" EXACT []
synonym: "down-regulation of glycolysis" EXACT []
synonym: "downregulation of glycolysis" EXACT []
synonym: "inhibition of glycolysis" NARROW []
is_a: GO:0006110 ! regulation of glycolytic process
is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1903579 ! negative regulation of ATP metabolic process
relationship: negatively_regulates GO:0006096 ! glycolytic process

[Term]
id: GO:0045821
name: positive regulation of glycolytic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycolysis." [GOC:go_curators]
synonym: "activation of glycolysis" NARROW []
synonym: "stimulation of glycolysis" NARROW []
synonym: "up regulation of glycolysis" EXACT []
synonym: "up-regulation of glycolysis" EXACT []
synonym: "upregulation of glycolysis" EXACT []
is_a: GO:0006110 ! regulation of glycolytic process
is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1903580 ! positive regulation of ATP metabolic process
relationship: positively_regulates GO:0006096 ! glycolytic process

[Term]
id: GO:0045822
name: negative regulation of heart contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "down regulation of heart contraction" EXACT []
synonym: "down-regulation of heart contraction" EXACT []
synonym: "downregulation of heart contraction" EXACT []
synonym: "inhibition of heart contraction" NARROW []
synonym: "negative regulation of cardiac contraction" RELATED []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903523 ! negative regulation of blood circulation
relationship: negatively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045823
name: positive regulation of heart contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "activation of heart contraction" NARROW []
synonym: "positive regulation of cardiac contraction" EXACT []
synonym: "stimulation of heart contraction" NARROW []
synonym: "up regulation of heart contraction" EXACT []
synonym: "up-regulation of heart contraction" EXACT []
synonym: "upregulation of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903524 ! positive regulation of blood circulation
relationship: positively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045824
name: negative regulation of innate immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
synonym: "down regulation of innate immune response" EXACT []
synonym: "down-regulation of innate immune response" EXACT []
synonym: "downregulation of innate immune response" EXACT []
synonym: "inhibition of innate immune response" NARROW []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045825
name: obsolete negative regulation of intermediate filament polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030840
consider: GO:0030843

[Term]
id: GO:0045826
name: obsolete positive regulation of intermediate filament polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030841
consider: GO:0030844

[Term]
id: GO:0045827
name: negative regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators]
synonym: "down regulation of isoprenoid metabolic process" EXACT []
synonym: "down-regulation of isoprenoid metabolic process" EXACT []
synonym: "downregulation of isoprenoid metabolic process" EXACT []
synonym: "inhibition of isoprenoid metabolic process" NARROW []
synonym: "negative regulation of isoprenoid metabolism" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0045828
name: positive regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators]
synonym: "activation of isoprenoid metabolic process" NARROW []
synonym: "positive regulation of isoprenoid metabolism" EXACT []
synonym: "stimulation of isoprenoid metabolic process" NARROW []
synonym: "up regulation of isoprenoid metabolic process" EXACT []
synonym: "up-regulation of isoprenoid metabolic process" EXACT []
synonym: "upregulation of isoprenoid metabolic process" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0045829
name: negative regulation of isotype switching
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators]
synonym: "down regulation of isotype switching" EXACT []
synonym: "down-regulation of isotype switching" EXACT []
synonym: "downregulation of isotype switching" EXACT []
synonym: "inhibition of isotype switching" NARROW []
synonym: "negative regulation of class switch recombination" EXACT []
synonym: "negative regulation of class switching" EXACT []
synonym: "negative regulation of isotype switch recombination" EXACT []
is_a: GO:0002638 ! negative regulation of immunoglobulin production
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0045191 ! regulation of isotype switching
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0050869 ! negative regulation of B cell activation
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045830
name: positive regulation of isotype switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators]
synonym: "activation of isotype switching" NARROW []
synonym: "positive regulation of class switch recombination" EXACT []
synonym: "positive regulation of class switching" EXACT []
synonym: "positive regulation of isotype switch recombination" EXACT []
synonym: "stimulation of isotype switching" NARROW []
synonym: "up regulation of isotype switching" EXACT []
synonym: "up-regulation of isotype switching" EXACT []
synonym: "upregulation of isotype switching" EXACT []
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0045191 ! regulation of isotype switching
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0050871 ! positive regulation of B cell activation
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045831
name: obsolete negative regulation of light-activated channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of light-activated channel activity" EXACT []
synonym: "down-regulation of light-activated channel activity" EXACT []
synonym: "downregulation of light-activated channel activity" EXACT []
synonym: "inhibition of light-activated channel activity" NARROW []
is_obsolete: true

[Term]
id: GO:0045832
name: obsolete positive regulation of light-activated channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of light-activated channel activity" NARROW []
synonym: "stimulation of light-activated channel activity" NARROW []
synonym: "up regulation of light-activated channel activity" EXACT []
synonym: "up-regulation of light-activated channel activity" EXACT []
synonym: "upregulation of light-activated channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0045833
name: negative regulation of lipid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "down regulation of lipid metabolic process" EXACT []
synonym: "down-regulation of lipid metabolic process" EXACT []
synonym: "downregulation of lipid metabolic process" EXACT []
synonym: "inhibition of lipid metabolic process" NARROW []
synonym: "negative regulation of lipid metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: negatively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045834
name: positive regulation of lipid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "activation of lipid metabolic process" NARROW []
synonym: "positive regulation of lipid metabolism" EXACT []
synonym: "stimulation of lipid metabolic process" NARROW []
synonym: "up regulation of lipid metabolic process" EXACT []
synonym: "up-regulation of lipid metabolic process" EXACT []
synonym: "upregulation of lipid metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: positively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045835
name: negative regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "down regulation of meiosis" EXACT []
synonym: "down-regulation of meiosis" EXACT []
synonym: "downregulation of meiosis" EXACT []
synonym: "inhibition of meiosis" NARROW []
synonym: "negative regulation of meiosis" EXACT []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
relationship: negatively_regulates GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0045836
name: positive regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "activation of meiosis" NARROW []
synonym: "positive regulation of meiosis" EXACT []
synonym: "stimulation of meiosis" NARROW []
synonym: "up regulation of meiosis" EXACT []
synonym: "up-regulation of meiosis" EXACT []
synonym: "upregulation of meiosis" EXACT []
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0045837
name: negative regulation of membrane potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators]
synonym: "down regulation of membrane potential" EXACT []
synonym: "down-regulation of membrane potential" EXACT []
synonym: "downregulation of membrane potential" EXACT []
synonym: "inhibition of membrane potential" NARROW []
synonym: "reduction of membrane potential" EXACT [GOC:rph]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0045838
name: positive regulation of membrane potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators]
synonym: "activation of membrane potential" NARROW []
synonym: "elevation of membrane potential" EXACT [GOC:rph]
synonym: "stimulation of membrane potential" NARROW []
synonym: "up regulation of membrane potential" EXACT []
synonym: "up-regulation of membrane potential" EXACT []
synonym: "upregulation of membrane potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0045839
name: negative regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of mitosis" EXACT []
synonym: "down-regulation of mitosis" EXACT []
synonym: "downregulation of mitosis" EXACT []
synonym: "inhibition of mitosis" NARROW []
synonym: "negative regulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
relationship: negatively_regulates GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0045840
name: positive regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "activation of mitosis" NARROW []
synonym: "mitogenic activity" NARROW []
synonym: "positive regulation of mitosis" EXACT []
synonym: "stimulation of mitosis" NARROW []
synonym: "up regulation of mitosis" EXACT []
synonym: "up-regulation of mitosis" EXACT []
synonym: "upregulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0045841
name: negative regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators]
synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW []
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0045839 ! negative regulation of mitotic nuclear division
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle
is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation
relationship: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle

[Term]
id: GO:0045842
name: positive regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators]
synonym: "activation of mitotic metaphase/anaphase transition" NARROW []
synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW []
synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT []
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle
relationship: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle

[Term]
id: GO:0045843
name: negative regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "down regulation of striated muscle development" EXACT []
synonym: "down-regulation of striated muscle development" EXACT []
synonym: "downregulation of striated muscle development" EXACT []
synonym: "inhibition of striated muscle development" NARROW []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048635 ! negative regulation of muscle organ development
is_a: GO:1901862 ! negative regulation of muscle tissue development
relationship: negatively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045844
name: positive regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "activation of striated muscle development" NARROW []
synonym: "stimulation of striated muscle development" NARROW []
synonym: "up regulation of striated muscle development" EXACT []
synonym: "up-regulation of striated muscle development" EXACT []
synonym: "upregulation of striated muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048636 ! positive regulation of muscle organ development
is_a: GO:1901863 ! positive regulation of muscle tissue development
relationship: positively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045847
name: negative regulation of nitrogen utilization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
synonym: "down regulation of nitrogen utilization" EXACT []
synonym: "down-regulation of nitrogen utilization" EXACT []
synonym: "downregulation of nitrogen utilization" EXACT []
synonym: "inhibition of nitrogen utilization" NARROW []
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:0032108 ! negative regulation of response to nutrient levels
relationship: negatively_regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0045848
name: positive regulation of nitrogen utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
synonym: "activation of nitrogen utilization" NARROW []
synonym: "stimulation of nitrogen utilization" NARROW []
synonym: "up regulation of nitrogen utilization" EXACT []
synonym: "up-regulation of nitrogen utilization" EXACT []
synonym: "upregulation of nitrogen utilization" EXACT []
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:0032109 ! positive regulation of response to nutrient levels
relationship: positively_regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0045849
name: negative regulation of nurse cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "down regulation of nurse cell apoptosis" EXACT []
synonym: "down-regulation of nurse cell apoptosis" EXACT []
synonym: "downregulation of nurse cell apoptosis" EXACT []
synonym: "inhibition of nurse cell apoptosis" NARROW []
synonym: "negative regulation of nurse cell apoptosis" NARROW []
is_a: GO:0045477 ! regulation of nurse cell apoptotic process
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0045476 ! nurse cell apoptotic process

[Term]
id: GO:0045850
name: positive regulation of nurse cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "activation of nurse cell apoptosis" NARROW []
synonym: "positive regulation of nurse cell apoptosis" NARROW []
synonym: "stimulation of nurse cell apoptosis" NARROW []
synonym: "up regulation of nurse cell apoptosis" EXACT []
synonym: "up-regulation of nurse cell apoptosis" EXACT []
synonym: "upregulation of nurse cell apoptosis" EXACT []
is_a: GO:0045477 ! regulation of nurse cell apoptotic process
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0045476 ! nurse cell apoptotic process

[Term]
id: GO:0045851
name: pH reduction
namespace: biological_process
def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators]
synonym: "acidification" EXACT []
is_a: GO:0006885 ! regulation of pH

[Term]
id: GO:0045852
name: pH elevation
namespace: biological_process
def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators]
is_a: GO:0006885 ! regulation of pH

[Term]
id: GO:0045853
name: negative regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators]
synonym: "down regulation of bicoid mRNA localization" EXACT []
synonym: "down-regulation of bicoid mRNA localization" EXACT []
synonym: "downregulation of bicoid mRNA localization" EXACT []
synonym: "inhibition of bicoid mRNA localization" NARROW []
synonym: "negative regulation of bicoid mRNA localisation" EXACT [GOC:mah]
is_a: GO:0008359 ! regulation of bicoid mRNA localization
is_a: GO:1904581 ! negative regulation of intracellular mRNA localization
relationship: negatively_regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0045854
name: positive regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators]
synonym: "activation of bicoid mRNA localization" NARROW []
synonym: "positive regulation of bicoid mRNA localisation" EXACT [GOC:mah]
synonym: "stimulation of bicoid mRNA localization" NARROW []
synonym: "up regulation of bicoid mRNA localization" EXACT []
synonym: "up-regulation of bicoid mRNA localization" EXACT []
synonym: "upregulation of bicoid mRNA localization" EXACT []
is_a: GO:0008359 ! regulation of bicoid mRNA localization
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:1904582 ! positive regulation of intracellular mRNA localization
relationship: positively_regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0045855
name: negative regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "down regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "down-regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "downregulation of pole plasm oskar mRNA localization" EXACT []
synonym: "inhibition of pole plasm oskar mRNA localization" NARROW []
synonym: "negative regulation of oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "negative regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah]
is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization
is_a: GO:1904581 ! negative regulation of intracellular mRNA localization
relationship: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0045856
name: positive regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "activation of pole plasm oskar mRNA localization" NARROW []
synonym: "positive regulation of oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "positive regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah]
synonym: "stimulation of pole plasm oskar mRNA localization" NARROW []
synonym: "up regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "up-regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "upregulation of pole plasm oskar mRNA localization" EXACT []
is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization
is_a: GO:1904582 ! positive regulation of intracellular mRNA localization
relationship: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0045857
name: obsolete negative regulation of molecular function, epigenetic
namespace: biological_process
def: "OBSOLETE. Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
comment: This term was obsoleted because it is not an active process.
synonym: "down regulation of protein activity, epigenetic" EXACT []
synonym: "down-regulation of protein activity, epigenetic" EXACT []
synonym: "downregulation of protein activity, epigenetic" EXACT []
synonym: "inhibition of protein activity, epigenetic" NARROW []
synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0045858
name: obsolete positive regulation of molecular function, epigenetic
namespace: biological_process
def: "OBSOLETE. Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
comment: This term was obsoleted because it is not an active process.
synonym: "activation of protein activity, epigenetic" NARROW []
synonym: "positive regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of protein activity, epigenetic" NARROW []
synonym: "up regulation of protein activity, epigenetic" EXACT []
synonym: "up-regulation of protein activity, epigenetic" EXACT []
synonym: "upregulation of protein activity, epigenetic" EXACT []
is_obsolete: true

[Term]
id: GO:0045859
name: regulation of protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:0045860
name: positive regulation of protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
synonym: "stimulation of protein kinase activity" NARROW []
synonym: "up regulation of protein kinase activity" EXACT []
synonym: "up-regulation of protein kinase activity" EXACT []
synonym: "upregulation of protein kinase activity" EXACT []
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0045861
name: negative regulation of proteolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
synonym: "down regulation of proteolysis" EXACT []
synonym: "down-regulation of proteolysis" EXACT []
synonym: "downregulation of proteolysis" EXACT []
synonym: "inhibition of proteolysis" NARROW []
synonym: "negative regulation of peptidolysis" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0006508 ! proteolysis

[Term]
id: GO:0045862
name: positive regulation of proteolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
synonym: "activation of proteolysis" NARROW []
synonym: "positive regulation of peptidolysis" EXACT []
synonym: "stimulation of proteolysis" NARROW []
synonym: "up regulation of proteolysis" EXACT []
synonym: "up-regulation of proteolysis" EXACT []
synonym: "upregulation of proteolysis" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0006508 ! proteolysis

[Term]
id: GO:0045863
name: negative regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
synonym: "down regulation of pteridine metabolic process" EXACT []
synonym: "down-regulation of pteridine metabolic process" EXACT []
synonym: "downregulation of pteridine metabolic process" EXACT []
synonym: "inhibition of pteridine metabolic process" NARROW []
synonym: "negative regulation of pteridine metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
relationship: negatively_regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0045864
name: positive regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
synonym: "activation of pteridine metabolic process" NARROW []
synonym: "positive regulation of pteridine metabolism" EXACT []
synonym: "stimulation of pteridine metabolic process" NARROW []
synonym: "up regulation of pteridine metabolic process" EXACT []
synonym: "up-regulation of pteridine metabolic process" EXACT []
synonym: "upregulation of pteridine metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
relationship: positively_regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0045865
name: obsolete regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it describes a substrate-specific process.
synonym: "regulation of recombination within rDNA repeats" EXACT []
is_obsolete: true
replaced_by: GO:0000019

[Term]
id: GO:0045866
name: obsolete positive regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it describes a substrate-specific process.
synonym: "positive regulation of recombination within rDNA repeats" EXACT []
is_obsolete: true
consider: GO:0045951

[Term]
id: GO:0045869
name: negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators]
synonym: "down regulation of retroviral genome replication" EXACT []
synonym: "down-regulation of retroviral genome replication" EXACT []
synonym: "downregulation of retroviral genome replication" EXACT []
synonym: "inhibition of retroviral genome replication" NARROW []
synonym: "negative regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl]
synonym: "regulation of retroviral genome replication" RELATED []
is_a: GO:0045071 ! negative regulation of viral genome replication
is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate
is_a: GO:1902679 ! negative regulation of RNA biosynthetic process
relationship: negatively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate

[Term]
id: GO:0045870
name: positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retroviral genome replication." [GOC:go_curators]
synonym: "activation of retroviral genome replication" NARROW []
synonym: "positive regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl]
synonym: "stimulation of retroviral genome replication" NARROW []
synonym: "up regulation of retroviral genome replication" EXACT []
synonym: "up-regulation of retroviral genome replication" EXACT []
synonym: "upregulation of retroviral genome replication" EXACT []
is_a: GO:0045070 ! positive regulation of viral genome replication
is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate
is_a: GO:1902680 ! positive regulation of RNA biosynthetic process
relationship: positively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate

[Term]
id: GO:0045871
name: obsolete negative regulation of rhodopsin gene expression
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb]
comment: This term was obsoleted because it refers to a specific gene product. The gene product should be captured as an annotation extension using 'has input'.
synonym: "down regulation of rhodopsin gene activity" EXACT []
synonym: "down-regulation of rhodopsin gene activity" EXACT []
synonym: "downregulation of rhodopsin gene activity" EXACT []
synonym: "inhibition of rhodopsin gene activity" NARROW []
synonym: "negative regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:0045872
name: obsolete positive regulation of rhodopsin gene expression
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb]
comment: This term was obsoleted because it refers to a specific gene product. The gene product should be captured as an annotation extension using 'has input'.
synonym: "activation of rhodopsin gene activity" NARROW []
synonym: "positive regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of rhodopsin gene activity" NARROW []
synonym: "up regulation of rhodopsin gene activity" EXACT []
synonym: "up-regulation of rhodopsin gene activity" EXACT []
synonym: "upregulation of rhodopsin gene activity" EXACT []
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0045873
name: negative regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "down regulation of sevenless signaling pathway" EXACT []
synonym: "down-regulation of sevenless signaling pathway" EXACT []
synonym: "downregulation of sevenless signaling pathway" EXACT []
synonym: "inhibition of sevenless signaling pathway" NARROW []
synonym: "negative regulation of sev signaling pathway" EXACT []
synonym: "negative regulation of sevenless signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0045501 ! regulation of sevenless signaling pathway
is_a: GO:0045677 ! negative regulation of R7 cell differentiation
relationship: negatively_regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045874
name: positive regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "activation of sevenless signaling pathway" NARROW []
synonym: "positive regulation of sev signaling pathway" EXACT []
synonym: "positive regulation of sevenless signalling pathway" EXACT []
synonym: "stimulation of sevenless signaling pathway" NARROW []
synonym: "up regulation of sevenless signaling pathway" EXACT []
synonym: "up-regulation of sevenless signaling pathway" EXACT []
synonym: "upregulation of sevenless signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0045501 ! regulation of sevenless signaling pathway
relationship: positively_regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045875
name: negative regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
synonym: "down regulation of sister chromatid cohesion" EXACT []
synonym: "down-regulation of sister chromatid cohesion" EXACT []
synonym: "downregulation of sister chromatid cohesion" EXACT []
synonym: "inhibition of sister chromatid cohesion" NARROW []
is_a: GO:0007063 ! regulation of sister chromatid cohesion
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0045876
name: positive regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
synonym: "activation of sister chromatid cohesion" NARROW []
synonym: "stimulation of sister chromatid cohesion" NARROW []
synonym: "up regulation of sister chromatid cohesion" EXACT []
synonym: "up-regulation of sister chromatid cohesion" EXACT []
synonym: "upregulation of sister chromatid cohesion" EXACT []
is_a: GO:0007063 ! regulation of sister chromatid cohesion
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0045879
name: negative regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0045877
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "down regulation of smoothened signaling pathway" EXACT []
synonym: "down-regulation of smoothened signaling pathway" EXACT []
synonym: "downregulation of smoothened signaling pathway" EXACT []
synonym: "inhibition of smoothened signaling pathway" NARROW []
synonym: "negative regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of smoothened activity" RELATED []
synonym: "negative regulation of smoothened by patched" NARROW []
synonym: "negative regulation of smoothened receptor activity by patched" RELATED []
synonym: "negative regulation of smoothened signalling pathway" EXACT []
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0045880
name: positive regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0045878
def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "activation of smoothened signaling pathway" NARROW []
synonym: "positive regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "positive regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "positive regulation of smoothened by patched" RELATED []
synonym: "positive regulation of smoothened receptor activity by patched" RELATED []
synonym: "positive regulation of smoothened signalling pathway" EXACT []
synonym: "stimulation of smoothened signaling pathway" NARROW []
synonym: "up regulation of smoothened signaling pathway" EXACT []
synonym: "up-regulation of smoothened signaling pathway" EXACT []
synonym: "upregulation of smoothened signaling pathway" EXACT []
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0045881
name: positive regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators]
synonym: "activation of sporulation" NARROW []
synonym: "stimulation of sporulation" NARROW []
synonym: "up regulation of sporulation" EXACT []
synonym: "up-regulation of sporulation" EXACT []
synonym: "upregulation of sporulation" EXACT []
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043938 ! positive regulation of sporulation
relationship: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0045882
name: negative regulation of sulfur utilization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
synonym: "down regulation of sulfur utilization" EXACT []
synonym: "down-regulation of sulfur utilization" EXACT []
synonym: "downregulation of sulfur utilization" EXACT []
synonym: "inhibition of sulfur utilization" NARROW []
synonym: "negative regulation of sulphur utilization" EXACT []
is_a: GO:0006792 ! regulation of sulfur utilization
is_a: GO:0032108 ! negative regulation of response to nutrient levels
relationship: negatively_regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0045883
name: positive regulation of sulfur utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
synonym: "activation of sulfur utilization" NARROW []
synonym: "positive regulation of sulphur utilization" EXACT []
synonym: "stimulation of sulfur utilization" NARROW []
synonym: "up regulation of sulfur utilization" EXACT []
synonym: "up-regulation of sulfur utilization" EXACT []
synonym: "upregulation of sulfur utilization" EXACT []
is_a: GO:0006792 ! regulation of sulfur utilization
is_a: GO:0032109 ! positive regulation of response to nutrient levels
relationship: positively_regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0045884
name: obsolete regulation of survival gene product expression
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb]
comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc.
synonym: "regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "regulation of survival gene product expression" EXACT []
synonym: "regulation of survival gene products" BROAD []
is_obsolete: true

[Term]
id: GO:0045885
name: obsolete positive regulation of survival gene product expression
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb]
comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc.
synonym: "activation of survival gene product activity" BROAD []
synonym: "positive regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "positive regulation of survival gene product expression" EXACT []
synonym: "positive regulation of survival gene products" BROAD []
synonym: "stimulation of survival gene product activity" NARROW []
synonym: "up regulation of survival gene product activity" BROAD []
synonym: "up-regulation of survival gene product activity" BROAD []
synonym: "upregulation of survival gene product activity" BROAD []
is_obsolete: true

[Term]
id: GO:0045886
name: negative regulation of synaptic assembly at neuromuscular junction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic assembly at neuromuscular junction." [GOC:go_curators]
synonym: "down regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "down-regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "downregulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "inhibition of synaptic growth at neuromuscular junction" NARROW []
synonym: "negative regulation of synaptic growth at neuromuscular junction" RELATED []
is_a: GO:0008582 ! regulation of synaptic assembly at neuromuscular junction
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1904397 ! negative regulation of neuromuscular junction development
relationship: negatively_regulates GO:0051124 ! synaptic assembly at neuromuscular junction

[Term]
id: GO:0045887
name: positive regulation of synaptic assembly at neuromuscular junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction." [GOC:go_curators]
synonym: "activation of synaptic growth at neuromuscular junction" NARROW []
synonym: "positive regulation of synaptic growth at neuromuscular junction" RELATED []
synonym: "stimulation of synaptic growth at neuromuscular junction" NARROW []
synonym: "up regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "up-regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "upregulation of synaptic growth at neuromuscular junction" EXACT []
is_a: GO:0008582 ! regulation of synaptic assembly at neuromuscular junction
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051965 ! positive regulation of synapse assembly
is_a: GO:1904398 ! positive regulation of neuromuscular junction development
relationship: positively_regulates GO:0051124 ! synaptic assembly at neuromuscular junction

[Term]
id: GO:0045888
name: obsolete regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "regulation of transcription of homeotic gene (Polycomb group)" EXACT []
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0045889
name: obsolete positive regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "positive regulation of transcription of homeotic gene (Polycomb group)" EXACT []
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0045890
name: obsolete regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "regulation of transcription of homeotic gene (trithorax group)" EXACT []
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0045891
name: obsolete negative regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "negative regulation of transcription of homeotic gene (trithorax group)" EXACT []
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:0045892
name: negative regulation of DNA-templated transcription
namespace: biological_process
alt_id: GO:0016481
alt_id: GO:0032582
alt_id: GO:0061021
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "down regulation of gene-specific transcription" RELATED []
synonym: "down regulation of transcription, DNA-dependent" EXACT []
synonym: "down-regulation of gene-specific transcription" RELATED []
synonym: "down-regulation of transcription, DNA-dependent" EXACT []
synonym: "downregulation of gene-specific transcription" RELATED []
synonym: "downregulation of transcription, DNA-dependent" EXACT []
synonym: "inhibition of gene-specific transcription" RELATED []
synonym: "inhibition of transcription, DNA-dependent" NARROW []
synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "negative regulation of gene-specific transcription" RELATED []
synonym: "negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "negative regulation of transcription, DNA-templated" EXACT []
synonym: "transcription repressor activity" RELATED []
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:1902679 ! negative regulation of RNA biosynthetic process
relationship: negatively_regulates GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0045893
name: positive regulation of DNA-templated transcription
namespace: biological_process
alt_id: GO:0043193
alt_id: GO:0045941
alt_id: GO:0061020
def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "activation of gene-specific transcription" RELATED []
synonym: "activation of transcription, DNA-dependent" NARROW []
synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "positive regulation of gene-specific transcription" RELATED []
synonym: "positive regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "positive regulation of transcription, DNA-templated" EXACT []
synonym: "stimulation of gene-specific transcription" NARROW []
synonym: "stimulation of transcription, DNA-dependent" NARROW []
synonym: "transcription activator activity" RELATED []
synonym: "up regulation of gene-specific transcription" RELATED []
synonym: "up regulation of transcription, DNA-dependent" EXACT []
synonym: "up-regulation of gene-specific transcription" RELATED []
synonym: "up-regulation of transcription, DNA-dependent" EXACT []
synonym: "upregulation of gene-specific transcription" RELATED []
synonym: "upregulation of transcription, DNA-dependent" EXACT []
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:1902680 ! positive regulation of RNA biosynthetic process
relationship: positively_regulates GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0045894
name: negative regulation of mating-type specific transcription, DNA-templated
namespace: biological_process
def: "Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "down regulation of transcription, mating-type specific" EXACT []
synonym: "down-regulation of transcription, mating-type specific" EXACT []
synonym: "downregulation of transcription, mating-type specific" EXACT []
synonym: "inhibition of transcription, mating-type specific" NARROW []
synonym: "negative regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH]
is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated
is_a: GO:0045892 ! negative regulation of DNA-templated transcription

[Term]
id: GO:0045895
name: positive regulation of mating-type specific transcription, DNA-templated
namespace: biological_process
def: "Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "activation of transcription, mating-type specific" NARROW []
synonym: "positive regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "stimulation of transcription, mating-type specific" NARROW []
synonym: "up regulation of transcription, mating-type specific" EXACT []
synonym: "up-regulation of transcription, mating-type specific" EXACT []
synonym: "upregulation of transcription, mating-type specific" EXACT []
is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated
is_a: GO:0045893 ! positive regulation of DNA-templated transcription

[Term]
id: GO:0045896
name: obsolete regulation of transcription during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "mitotic regulation of transcription" EXACT []
synonym: "regulation of transcription, mitotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006357
consider: GO:0044772

[Term]
id: GO:0045897
name: obsolete positive regulation of transcription during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "activation of transcription during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription" EXACT []
synonym: "positive regulation of transcription, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription during mitosis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0044772
consider: GO:0045944

[Term]
id: GO:0045898
name: regulation of RNA polymerase II transcription preinitiation complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "regulation of RNA polymerase II transcriptional preinitiation complex formation" RELATED []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0060260 ! regulation of transcription initiation by RNA polymerase II
relationship: regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly

[Term]
id: GO:0045899
name: positive regulation of RNA polymerase II transcription preinitiation complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "activation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT []
synonym: "stimulation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "up regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "up-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "upregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0045898 ! regulation of RNA polymerase II transcription preinitiation complex assembly
is_a: GO:0060261 ! positive regulation of transcription initiation by RNA polymerase II
relationship: positively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly

[Term]
id: GO:0045900
name: negative regulation of translational elongation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]
synonym: "down regulation of translational elongation" EXACT []
synonym: "down-regulation of translational elongation" EXACT []
synonym: "downregulation of translational elongation" EXACT []
synonym: "inhibition of translational elongation" NARROW []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0017148 ! negative regulation of translation
relationship: negatively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045901
name: positive regulation of translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]
synonym: "activation of translational elongation" NARROW []
synonym: "stimulation of translational elongation" NARROW []
synonym: "up regulation of translational elongation" EXACT []
synonym: "up-regulation of translational elongation" EXACT []
synonym: "upregulation of translational elongation" EXACT []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0045727 ! positive regulation of translation
relationship: positively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045902
name: negative regulation of translational fidelity
namespace: biological_process
def: "Any process that decreases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
synonym: "down regulation of translational fidelity" EXACT []
synonym: "down-regulation of translational fidelity" EXACT []
synonym: "downregulation of translational fidelity" EXACT []
synonym: "inhibition of translational fidelity" NARROW []
is_a: GO:0006450 ! regulation of translational fidelity
is_a: GO:0017148 ! negative regulation of translation

[Term]
id: GO:0045903
name: positive regulation of translational fidelity
namespace: biological_process
def: "Any process that increases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
synonym: "activation of translational fidelity" NARROW []
synonym: "stimulation of translational fidelity" NARROW []
synonym: "up regulation of translational fidelity" EXACT []
synonym: "up-regulation of translational fidelity" EXACT []
synonym: "upregulation of translational fidelity" EXACT []
is_a: GO:0006450 ! regulation of translational fidelity
is_a: GO:0045727 ! positive regulation of translation

[Term]
id: GO:0045904
name: negative regulation of translational termination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators]
synonym: "down regulation of translational termination" EXACT []
synonym: "down-regulation of translational termination" EXACT []
synonym: "downregulation of translational termination" EXACT []
synonym: "inhibition of translational termination" NARROW []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
relationship: negatively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045905
name: positive regulation of translational termination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]
synonym: "activation of translational termination" NARROW []
synonym: "stimulation of translational termination" NARROW []
synonym: "up regulation of translational termination" EXACT []
synonym: "up-regulation of translational termination" EXACT []
synonym: "upregulation of translational termination" EXACT []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:0045727 ! positive regulation of translation
relationship: positively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045906
name: negative regulation of vasoconstriction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction." [GOC:go_curators]
synonym: "down regulation of vasoconstriction" EXACT []
synonym: "down-regulation of vasoconstriction" EXACT []
synonym: "downregulation of vasoconstriction" EXACT []
synonym: "inhibition of vasoconstriction" NARROW []
is_a: GO:0019229 ! regulation of vasoconstriction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0045907
name: positive regulation of vasoconstriction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasoconstriction." [GOC:go_curators]
synonym: "activation of vasoconstriction" NARROW []
synonym: "stimulation of vasoconstriction" NARROW []
synonym: "up regulation of vasoconstriction" EXACT []
synonym: "up-regulation of vasoconstriction" EXACT []
synonym: "upregulation of vasoconstriction" EXACT []
is_a: GO:0019229 ! regulation of vasoconstriction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0045910
name: negative regulation of DNA recombination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]
synonym: "down regulation of DNA recombination" EXACT []
synonym: "down-regulation of DNA recombination" EXACT []
synonym: "downregulation of DNA recombination" EXACT []
synonym: "inhibition of DNA recombination" NARROW []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0045911
name: positive regulation of DNA recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators]
synonym: "activation of DNA recombination" NARROW []
synonym: "stimulation of DNA recombination" NARROW []
synonym: "up regulation of DNA recombination" EXACT []
synonym: "up-regulation of DNA recombination" EXACT []
synonym: "upregulation of DNA recombination" EXACT []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0045912
name: negative regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
synonym: "down regulation of carbohydrate metabolic process" EXACT []
synonym: "down-regulation of carbohydrate metabolic process" EXACT []
synonym: "downregulation of carbohydrate metabolic process" EXACT []
synonym: "inhibition of carbohydrate metabolic process" NARROW []
synonym: "negative regulation of carbohydrate metabolism" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009892 ! negative regulation of metabolic process
relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045913
name: positive regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
synonym: "activation of carbohydrate metabolic process" NARROW []
synonym: "positive regulation of carbohydrate metabolism" EXACT []
synonym: "stimulation of carbohydrate metabolic process" NARROW []
synonym: "up regulation of carbohydrate metabolic process" EXACT []
synonym: "up-regulation of carbohydrate metabolic process" EXACT []
synonym: "upregulation of carbohydrate metabolic process" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045914
name: negative regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
synonym: "down regulation of catecholamine metabolic process" EXACT []
synonym: "down-regulation of catecholamine metabolic process" EXACT []
synonym: "downregulation of catecholamine metabolic process" EXACT []
synonym: "inhibition of catecholamine metabolic process" NARROW []
synonym: "negative regulation of catecholamine metabolism" EXACT []
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045915
name: positive regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
synonym: "activation of catecholamine metabolic process" NARROW []
synonym: "positive regulation of catecholamine metabolism" EXACT []
synonym: "stimulation of catecholamine metabolic process" NARROW []
synonym: "up regulation of catecholamine metabolic process" EXACT []
synonym: "up-regulation of catecholamine metabolic process" EXACT []
synonym: "upregulation of catecholamine metabolic process" EXACT []
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
relationship: positively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045916
name: negative regulation of complement activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "down regulation of complement activation" EXACT []
synonym: "down-regulation of complement activation" EXACT []
synonym: "downregulation of complement activation" EXACT []
synonym: "inhibition of complement activation" NARROW []
synonym: "negative regulation of complement cascade" EXACT [GOC:add]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0030449 ! regulation of complement activation
relationship: negatively_regulates GO:0006956 ! complement activation

[Term]
id: GO:0045917
name: positive regulation of complement activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "activation of complement activation" NARROW []
synonym: "positive regulation of complement cascade" EXACT [GOC:add]
synonym: "stimulation of complement activation" NARROW []
synonym: "up regulation of complement activation" EXACT []
synonym: "up-regulation of complement activation" EXACT []
synonym: "upregulation of complement activation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0030449 ! regulation of complement activation
relationship: positively_regulates GO:0006956 ! complement activation

[Term]
id: GO:0045918
name: negative regulation of cytolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis." [GOC:go_curators]
synonym: "down regulation of cytolysis" EXACT []
synonym: "down-regulation of cytolysis" EXACT []
synonym: "downregulation of cytolysis" EXACT []
synonym: "inhibition of cytolysis" NARROW []
is_a: GO:0042268 ! regulation of cytolysis
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0019835 ! cytolysis

[Term]
id: GO:0045919
name: positive regulation of cytolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytolysis." [GOC:go_curators]
synonym: "activation of cytolysis" NARROW []
synonym: "stimulation of cytolysis" NARROW []
synonym: "up regulation of cytolysis" EXACT []
synonym: "up-regulation of cytolysis" EXACT []
synonym: "upregulation of cytolysis" EXACT []
is_a: GO:0042268 ! regulation of cytolysis
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0019835 ! cytolysis

[Term]
id: GO:0045920
name: negative regulation of exocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "down regulation of exocytosis" EXACT []
synonym: "down-regulation of exocytosis" EXACT []
synonym: "downregulation of exocytosis" EXACT []
synonym: "inhibition of exocytosis" NARROW []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045921
name: positive regulation of exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "activation of exocytosis" NARROW []
synonym: "stimulation of exocytosis" NARROW []
synonym: "up regulation of exocytosis" EXACT []
synonym: "up-regulation of exocytosis" EXACT []
synonym: "upregulation of exocytosis" EXACT []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045922
name: negative regulation of fatty acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
synonym: "down regulation of fatty acid metabolic process" EXACT []
synonym: "down-regulation of fatty acid metabolic process" EXACT []
synonym: "downregulation of fatty acid metabolic process" EXACT []
synonym: "inhibition of fatty acid metabolic process" NARROW []
synonym: "negative regulation of fatty acid metabolism" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0045923
name: positive regulation of fatty acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
synonym: "activation of fatty acid metabolic process" NARROW []
synonym: "positive regulation of fatty acid metabolism" EXACT []
synonym: "stimulation of fatty acid metabolic process" NARROW []
synonym: "up regulation of fatty acid metabolic process" EXACT []
synonym: "up-regulation of fatty acid metabolic process" EXACT []
synonym: "upregulation of fatty acid metabolic process" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0045924
name: regulation of female receptivity
namespace: biological_process
alt_id: GO:0060181
def: "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "female receptivity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0060180 ! female mating behavior
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0045925
name: positive regulation of female receptivity
namespace: biological_process
def: "Any process that activates or increases the receptiveness of a female to male advances." [GOC:go_curators]
synonym: "activation of female receptivity" NARROW []
synonym: "stimulation of female receptivity" NARROW []
synonym: "up regulation of female receptivity" EXACT []
synonym: "up-regulation of female receptivity" EXACT []
synonym: "upregulation of female receptivity" EXACT []
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0045926
name: negative regulation of growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
synonym: "down regulation of growth" EXACT []
synonym: "down-regulation of growth" EXACT []
synonym: "downregulation of growth" EXACT []
synonym: "inhibition of growth" NARROW []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0040007 ! growth

[Term]
id: GO:0045927
name: positive regulation of growth
namespace: biological_process
def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
synonym: "activation of growth" NARROW []
synonym: "stimulation of growth" NARROW []
synonym: "up regulation of growth" EXACT []
synonym: "up-regulation of growth" EXACT []
synonym: "upregulation of growth" EXACT []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0040007 ! growth

[Term]
id: GO:0045928
name: negative regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone metabolic process" EXACT []
synonym: "down-regulation of juvenile hormone metabolic process" EXACT []
synonym: "downregulation of juvenile hormone metabolic process" EXACT []
synonym: "inhibition of juvenile hormone metabolic process" NARROW []
synonym: "negative regulation of juvenile hormone metabolism" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
relationship: negatively_regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0045929
name: positive regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone metabolic process" NARROW []
synonym: "positive regulation of juvenile hormone metabolism" EXACT []
synonym: "stimulation of juvenile hormone metabolic process" NARROW []
synonym: "up regulation of juvenile hormone metabolic process" EXACT []
synonym: "up-regulation of juvenile hormone metabolic process" EXACT []
synonym: "upregulation of juvenile hormone metabolic process" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
relationship: positively_regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0045930
name: negative regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through mitotic cell cycle" EXACT []
synonym: "downregulation of progression through mitotic cell cycle" EXACT []
synonym: "inhibition of progression through mitotic cell cycle" NARROW []
synonym: "negative regulation of mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045786 ! negative regulation of cell cycle
relationship: negatively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045931
name: positive regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through mitotic cell cycle" NARROW []
synonym: "positive regulation of mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through mitotic cell cycle" NARROW []
synonym: "up regulation of progression through mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through mitotic cell cycle" EXACT []
synonym: "upregulation of progression through mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045787 ! positive regulation of cell cycle
relationship: positively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045932
name: negative regulation of muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "down regulation of muscle contraction" EXACT []
synonym: "down-regulation of muscle contraction" EXACT []
synonym: "downregulation of muscle contraction" EXACT []
synonym: "inhibition of muscle contraction" NARROW []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045933
name: positive regulation of muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "activation of muscle contraction" NARROW []
synonym: "stimulation of muscle contraction" NARROW []
synonym: "up regulation of muscle contraction" EXACT []
synonym: "up-regulation of muscle contraction" EXACT []
synonym: "upregulation of muscle contraction" EXACT []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045934
name: negative regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0045935
name: positive regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0045936
name: negative regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "down regulation of phosphate metabolic process" EXACT []
synonym: "down-regulation of phosphate metabolic process" EXACT []
synonym: "downregulation of phosphate metabolic process" EXACT []
synonym: "inhibition of phosphate metabolic process" NARROW []
synonym: "negative regulation of phosphate metabolism" EXACT []
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0045937
name: positive regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "activation of phosphate metabolic process" NARROW []
synonym: "positive regulation of phosphate metabolism" EXACT []
synonym: "stimulation of phosphate metabolic process" NARROW []
synonym: "up regulation of phosphate metabolic process" EXACT []
synonym: "up-regulation of phosphate metabolic process" EXACT []
synonym: "upregulation of phosphate metabolic process" EXACT []
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0045938
name: positive regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, sleep" NARROW []
synonym: "positive regulation of sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT []
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
is_a: GO:0048520 ! positive regulation of behavior
relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0045939
name: negative regulation of steroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "down regulation of steroid metabolic process" EXACT []
synonym: "down-regulation of steroid metabolic process" EXACT []
synonym: "downregulation of steroid metabolic process" EXACT []
synonym: "inhibition of steroid metabolic process" NARROW []
synonym: "negative regulation of steroid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
relationship: negatively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045940
name: positive regulation of steroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "activation of steroid metabolic process" NARROW []
synonym: "positive regulation of steroid metabolism" EXACT []
synonym: "stimulation of steroid metabolic process" NARROW []
synonym: "up regulation of steroid metabolic process" EXACT []
synonym: "up-regulation of steroid metabolic process" EXACT []
synonym: "upregulation of steroid metabolic process" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
relationship: positively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045942
name: negative regulation of phosphorus utilization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
synonym: "down regulation of phosphorus utilization" EXACT []
synonym: "down-regulation of phosphorus utilization" EXACT []
synonym: "downregulation of phosphorus utilization" EXACT []
synonym: "inhibition of phosphorus utilization" NARROW []
is_a: GO:0006795 ! regulation of phosphorus utilization
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
relationship: negatively_regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0045943
name: positive regulation of transcription by RNA polymerase I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]
synonym: "activation of transcription from RNA polymerase I promoter" NARROW []
synonym: "positive regulation of transcription from Pol I promoter" EXACT []
synonym: "positive regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "stimulation of transcription from RNA polymerase I promoter" NARROW []
synonym: "up regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "up-regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "upregulation of transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0006356 ! regulation of transcription by RNA polymerase I
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
relationship: positively_regulates GO:0006360 ! transcription by RNA polymerase I

[Term]
id: GO:0045944
name: positive regulation of transcription by RNA polymerase II
namespace: biological_process
alt_id: GO:0010552
alt_id: GO:0045817
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
synonym: "activation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "activation of transcription from RNA polymerase II promoter" EXACT []
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "positive regulation of global transcription from Pol II promoter" RELATED []
synonym: "positive regulation of transcription from Pol II promoter" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED []
synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
relationship: positively_regulates GO:0006366 ! transcription by RNA polymerase II

[Term]
id: GO:0045945
name: positive regulation of transcription by RNA polymerase III
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH]
synonym: "activation of transcription from RNA polymerase III promoter" NARROW []
synonym: "positive regulation of transcription from Pol III promoter" EXACT []
synonym: "positive regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "stimulation of transcription from RNA polymerase III promoter" NARROW []
synonym: "up regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "up-regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "upregulation of transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0006359 ! regulation of transcription by RNA polymerase III
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
relationship: positively_regulates GO:0006383 ! transcription by RNA polymerase III

[Term]
id: GO:0045947
name: negative regulation of translational initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]
synonym: "down regulation of translational initiation" EXACT []
synonym: "down-regulation of translational initiation" EXACT []
synonym: "downregulation of translational initiation" EXACT []
synonym: "inhibition of translational initiation" NARROW []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0017148 ! negative regulation of translation
relationship: negatively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045948
name: positive regulation of translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]
synonym: "activation of translational initiation" NARROW []
synonym: "stimulation of translational initiation" NARROW []
synonym: "up regulation of translational initiation" EXACT []
synonym: "up-regulation of translational initiation" EXACT []
synonym: "upregulation of translational initiation" EXACT []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0045727 ! positive regulation of translation
relationship: positively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045949
name: positive regulation of phosphorus utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
synonym: "activation of phosphorus utilization" NARROW []
synonym: "stimulation of phosphorus utilization" NARROW []
synonym: "up regulation of phosphorus utilization" EXACT []
synonym: "up-regulation of phosphorus utilization" EXACT []
synonym: "upregulation of phosphorus utilization" EXACT []
is_a: GO:0006795 ! regulation of phosphorus utilization
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
relationship: positively_regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0045950
name: negative regulation of mitotic recombination
namespace: biological_process
def: "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd]
synonym: "down regulation of mitotic recombination" EXACT []
synonym: "down-regulation of mitotic recombination" EXACT []
synonym: "downregulation of mitotic recombination" EXACT []
synonym: "inhibition of mitotic recombination" NARROW []
synonym: "negative regulation of recombination within rDNA repeats" NARROW []
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0045910 ! negative regulation of DNA recombination
relationship: negatively_regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0045951
name: positive regulation of mitotic recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]
synonym: "activation of mitotic recombination" NARROW []
synonym: "positive regulation of recombination within rDNA repeats" NARROW []
synonym: "stimulation of mitotic recombination" NARROW []
synonym: "up regulation of mitotic recombination" EXACT []
synonym: "up-regulation of mitotic recombination" EXACT []
synonym: "upregulation of mitotic recombination" EXACT []
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0045911 ! positive regulation of DNA recombination
relationship: positively_regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0045952
name: regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone breakdown" EXACT []
synonym: "regulation of juvenile hormone catabolism" EXACT []
synonym: "regulation of juvenile hormone degradation" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045953
name: negative regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of natural killer cell mediated cell death" EXACT []
synonym: "negative regulation of natural killer cell mediated cell killing" EXACT []
synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "negative regulation of NK cell mediated cell death" EXACT []
synonym: "negative regulation of NK cell mediated cell killing" EXACT []
synonym: "negative regulation of NK cell mediated cytolysis" RELATED []
synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
relationship: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0045954
name: positive regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of natural killer cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of natural killer cell mediated cell death" EXACT []
synonym: "positive regulation of natural killer cell mediated cell killing" EXACT []
synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "positive regulation of NK cell mediated cell death" EXACT []
synonym: "positive regulation of NK cell mediated cell killing" EXACT []
synonym: "positive regulation of NK cell mediated cytolysis" RELATED []
synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT []
synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW []
synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
relationship: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0045955
name: negative regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
synonym: "down regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "downregulation of calcium ion-dependent exocytosis" EXACT []
synonym: "inhibition of calcium ion-dependent exocytosis" NARROW []
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:1903306 ! negative regulation of regulated secretory pathway
relationship: negatively_regulates GO:0017156 ! calcium-ion regulated exocytosis

[Term]
id: GO:0045956
name: positive regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
synonym: "activation of calcium ion-dependent exocytosis" NARROW []
synonym: "stimulation of calcium ion-dependent exocytosis" NARROW []
synonym: "up regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "upregulation of calcium ion-dependent exocytosis" EXACT []
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:1903307 ! positive regulation of regulated secretory pathway
relationship: positively_regulates GO:0017156 ! calcium-ion regulated exocytosis

[Term]
id: GO:0045957
name: negative regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators]
synonym: "down regulation of complement activation, alternative pathway" EXACT []
synonym: "down-regulation of complement activation, alternative pathway" EXACT []
synonym: "downregulation of complement activation, alternative pathway" EXACT []
synonym: "inhibition of complement activation, alternative pathway" NARROW []
synonym: "negative regulation of complement cascade, alternative pathway" EXACT [GOC:add]
is_a: GO:0030451 ! regulation of complement activation, alternative pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0045958
name: positive regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators]
synonym: "activation of complement activation, alternative pathway" NARROW []
synonym: "positive regulation of complement cascade, alternative pathway" EXACT [GOC:add]
synonym: "stimulation of complement activation, alternative pathway" NARROW []
synonym: "up regulation of complement activation, alternative pathway" EXACT []
synonym: "up-regulation of complement activation, alternative pathway" EXACT []
synonym: "upregulation of complement activation, alternative pathway" EXACT []
is_a: GO:0030451 ! regulation of complement activation, alternative pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0045959
name: negative regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators]
synonym: "down regulation of complement activation, classical pathway" EXACT []
synonym: "down-regulation of complement activation, classical pathway" EXACT []
synonym: "downregulation of complement activation, classical pathway" EXACT []
synonym: "inhibition of complement activation, classical pathway" NARROW []
synonym: "negative regulation of complement cascade, classical pathway" EXACT [GOC:add]
is_a: GO:0002924 ! negative regulation of humoral immune response mediated by circulating immunoglobulin
is_a: GO:0030450 ! regulation of complement activation, classical pathway
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0045960
name: positive regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators]
synonym: "activation of complement activation, classical pathway" NARROW []
synonym: "positive regulation of complement cascade, classical pathway" EXACT [GOC:add]
synonym: "stimulation of complement activation, classical pathway" NARROW []
synonym: "up regulation of complement activation, classical pathway" EXACT []
synonym: "up-regulation of complement activation, classical pathway" EXACT []
synonym: "upregulation of complement activation, classical pathway" EXACT []
is_a: GO:0002925 ! positive regulation of humoral immune response mediated by circulating immunoglobulin
is_a: GO:0030450 ! regulation of complement activation, classical pathway
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0045961
name: negative regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [GOC:go_curators]
synonym: "down regulation of development, heterochronic" EXACT []
synonym: "down-regulation of development, heterochronic" EXACT []
synonym: "downregulation of development, heterochronic" EXACT []
synonym: "inhibition of development, heterochronic" NARROW []
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0045962
name: positive regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [GOC:go_curators]
synonym: "activation of development, heterochronic" NARROW []
synonym: "stimulation of development, heterochronic" NARROW []
synonym: "up regulation of development, heterochronic" EXACT []
synonym: "up-regulation of development, heterochronic" EXACT []
synonym: "upregulation of development, heterochronic" EXACT []
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0045963
name: negative regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "down regulation of dopamine metabolic process" EXACT []
synonym: "down-regulation of dopamine metabolic process" EXACT []
synonym: "downregulation of dopamine metabolic process" EXACT []
synonym: "inhibition of dopamine metabolic process" NARROW []
synonym: "negative regulation of dopamine metabolism" EXACT []
is_a: GO:0042053 ! regulation of dopamine metabolic process
is_a: GO:0045914 ! negative regulation of catecholamine metabolic process
relationship: negatively_regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0045964
name: positive regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "activation of dopamine metabolic process" NARROW []
synonym: "positive regulation of dopamine metabolism" EXACT []
synonym: "stimulation of dopamine metabolic process" NARROW []
synonym: "up regulation of dopamine metabolic process" EXACT []
synonym: "up-regulation of dopamine metabolic process" EXACT []
synonym: "upregulation of dopamine metabolic process" EXACT []
is_a: GO:0042053 ! regulation of dopamine metabolic process
is_a: GO:0045915 ! positive regulation of catecholamine metabolic process
relationship: positively_regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0045965
name: negative regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators]
synonym: "down regulation of ecdysteroid metabolic process" EXACT []
synonym: "down-regulation of ecdysteroid metabolic process" EXACT []
synonym: "downregulation of ecdysteroid metabolic process" EXACT []
synonym: "inhibition of ecdysteroid metabolic process" NARROW []
synonym: "negative regulation of ecdysteroid metabolism" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
relationship: negatively_regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045966
name: positive regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators]
synonym: "activation of ecdysteroid metabolic process" NARROW []
synonym: "positive regulation of ecdysteroid metabolism" EXACT []
synonym: "stimulation of ecdysteroid metabolic process" NARROW []
synonym: "up regulation of ecdysteroid metabolic process" EXACT []
synonym: "up-regulation of ecdysteroid metabolic process" EXACT []
synonym: "upregulation of ecdysteroid metabolic process" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
relationship: positively_regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045967
name: negative regulation of growth rate
namespace: biological_process
def: "Any process that reduces the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
synonym: "down regulation of growth rate" EXACT []
synonym: "down-regulation of growth rate" EXACT []
synonym: "downregulation of growth rate" EXACT []
synonym: "inhibition of growth rate" NARROW []
is_a: GO:0040009 ! regulation of growth rate
is_a: GO:0045926 ! negative regulation of growth

[Term]
id: GO:0045968
name: negative regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "downregulation of juvenile hormone biosynthetic process" EXACT []
synonym: "inhibition of juvenile hormone biosynthetic process" NARROW []
synonym: "negative regulation of juvenile hormone anabolism" EXACT []
synonym: "negative regulation of juvenile hormone biosynthesis" EXACT []
synonym: "negative regulation of juvenile hormone formation" EXACT []
synonym: "negative regulation of juvenile hormone synthesis" EXACT []
is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0045969
name: positive regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone biosynthetic process" NARROW []
synonym: "positive regulation of juvenile hormone anabolism" EXACT []
synonym: "positive regulation of juvenile hormone biosynthesis" EXACT []
synonym: "positive regulation of juvenile hormone formation" EXACT []
synonym: "positive regulation of juvenile hormone synthesis" EXACT []
synonym: "stimulation of juvenile hormone biosynthetic process" NARROW []
synonym: "up regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "upregulation of juvenile hormone biosynthetic process" EXACT []
is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process
is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
relationship: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0045970
name: negative regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone catabolic process" EXACT []
synonym: "down-regulation of juvenile hormone catabolic process" EXACT []
synonym: "downregulation of juvenile hormone catabolic process" EXACT []
synonym: "inhibition of juvenile hormone catabolic process" NARROW []
synonym: "negative regulation of juvenile hormone breakdown" EXACT []
synonym: "negative regulation of juvenile hormone catabolism" EXACT []
synonym: "negative regulation of juvenile hormone degradation" EXACT []
is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process
is_a: GO:0045952 ! regulation of juvenile hormone catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
relationship: negatively_regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045971
name: positive regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone catabolic process" NARROW []
synonym: "positive regulation of juvenile hormone breakdown" EXACT []
synonym: "positive regulation of juvenile hormone catabolism" EXACT []
synonym: "positive regulation of juvenile hormone degradation" EXACT []
synonym: "stimulation of juvenile hormone catabolic process" NARROW []
synonym: "up regulation of juvenile hormone catabolic process" EXACT []
synonym: "up-regulation of juvenile hormone catabolic process" EXACT []
synonym: "upregulation of juvenile hormone catabolic process" EXACT []
is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process
is_a: GO:0045952 ! regulation of juvenile hormone catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
relationship: positively_regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045972
name: negative regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone secretion" EXACT []
synonym: "down-regulation of juvenile hormone secretion" EXACT []
synonym: "downregulation of juvenile hormone secretion" EXACT []
synonym: "inhibition of juvenile hormone secretion" NARROW []
is_a: GO:0007558 ! regulation of juvenile hormone secretion
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0045973
name: positive regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone secretion" NARROW []
synonym: "stimulation of juvenile hormone secretion" NARROW []
synonym: "up regulation of juvenile hormone secretion" EXACT []
synonym: "up-regulation of juvenile hormone secretion" EXACT []
synonym: "upregulation of juvenile hormone secretion" EXACT []
is_a: GO:0007558 ! regulation of juvenile hormone secretion
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0045974
name: regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb]
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0045975
name: positive regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of mRNA translation, ncRNA-mediated" NARROW []
synonym: "stimulation of mRNA translation, ncRNA-mediated" NARROW []
synonym: "up regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "up-regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "upregulation of mRNA translation, ncRNA-mediated" EXACT []
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0045974 ! regulation of translation, ncRNA-mediated

[Term]
id: GO:0045976
name: negative regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW []
synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
relationship: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0045977
name: positive regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of mitotic cell cycle, embryonic" NARROW []
synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of mitotic cell cycle, embryonic" NARROW []
synonym: "up regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "upregulation of mitotic cell cycle, embryonic" EXACT []
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
relationship: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0045978
name: negative regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
synonym: "down regulation of nucleoside metabolic process" EXACT []
synonym: "down-regulation of nucleoside metabolic process" EXACT []
synonym: "downregulation of nucleoside metabolic process" EXACT []
synonym: "inhibition of nucleoside metabolic process" NARROW []
synonym: "negative regulation of nucleoside metabolism" EXACT []
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0045979
name: positive regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
synonym: "activation of nucleoside metabolic process" NARROW []
synonym: "positive regulation of nucleoside metabolism" EXACT []
synonym: "stimulation of nucleoside metabolic process" NARROW []
synonym: "up regulation of nucleoside metabolic process" EXACT []
synonym: "up-regulation of nucleoside metabolic process" EXACT []
synonym: "upregulation of nucleoside metabolic process" EXACT []
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0045980
name: negative regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
synonym: "down regulation of nucleotide metabolic process" EXACT []
synonym: "down-regulation of nucleotide metabolic process" EXACT []
synonym: "downregulation of nucleotide metabolic process" EXACT []
synonym: "inhibition of nucleotide metabolic process" NARROW []
synonym: "negative regulation of nucleotide metabolism" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0045981
name: positive regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
synonym: "activation of nucleotide metabolic process" NARROW []
synonym: "positive regulation of nucleotide metabolism" EXACT []
synonym: "stimulation of nucleotide metabolic process" NARROW []
synonym: "up regulation of nucleotide metabolic process" EXACT []
synonym: "up-regulation of nucleotide metabolic process" EXACT []
synonym: "upregulation of nucleotide metabolic process" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0045982
name: negative regulation of purine nucleobase metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases." [GOC:go_curators]
synonym: "down regulation of purine base metabolic process" EXACT []
synonym: "down-regulation of purine base metabolic process" EXACT []
synonym: "downregulation of purine base metabolic process" EXACT []
synonym: "inhibition of purine base metabolic process" NARROW []
synonym: "negative regulation of purine base metabolic process" EXACT [GOC:go_curators]
synonym: "negative regulation of purine base metabolism" EXACT []
is_a: GO:0006141 ! regulation of purine nucleobase metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0045983
name: positive regulation of purine nucleobase metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators]
synonym: "activation of purine base metabolic process" NARROW []
synonym: "positive regulation of purine base metabolic process" EXACT []
synonym: "positive regulation of purine base metabolism" EXACT []
synonym: "stimulation of purine base metabolic process" NARROW []
synonym: "up regulation of purine base metabolic process" EXACT []
synonym: "up-regulation of purine base metabolic process" EXACT []
synonym: "upregulation of purine base metabolic process" EXACT []
is_a: GO:0006141 ! regulation of purine nucleobase metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0045984
name: negative regulation of pyrimidine nucleobase metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators]
synonym: "down regulation of pyrimidine base metabolic process" EXACT []
synonym: "down-regulation of pyrimidine base metabolic process" EXACT []
synonym: "downregulation of pyrimidine base metabolic process" EXACT []
synonym: "inhibition of pyrimidine base metabolic process" NARROW []
synonym: "negative regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "negative regulation of pyrimidine base metabolism" EXACT []
is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0045985
name: positive regulation of pyrimidine nucleobase metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators]
synonym: "activation of pyrimidine base metabolic process" NARROW []
synonym: "positive regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "positive regulation of pyrimidine base metabolism" EXACT []
synonym: "stimulation of pyrimidine base metabolic process" NARROW []
synonym: "up regulation of pyrimidine base metabolic process" EXACT []
synonym: "up-regulation of pyrimidine base metabolic process" EXACT []
synonym: "upregulation of pyrimidine base metabolic process" EXACT []
is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0045986
name: negative regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of smooth muscle contraction" EXACT []
synonym: "down-regulation of smooth muscle contraction" EXACT []
synonym: "downregulation of smooth muscle contraction" EXACT []
synonym: "inhibition of smooth muscle contraction" NARROW []
synonym: "smooth muscle relaxation" RELATED []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
relationship: negatively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045987
name: positive regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "activation of smooth muscle contraction" NARROW []
synonym: "stimulation of smooth muscle contraction" NARROW []
synonym: "up regulation of smooth muscle contraction" EXACT []
synonym: "up-regulation of smooth muscle contraction" EXACT []
synonym: "upregulation of smooth muscle contraction" EXACT []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
relationship: positively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045988
name: negative regulation of striated muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "down regulation of striated muscle contraction" EXACT []
synonym: "down-regulation of striated muscle contraction" EXACT []
synonym: "downregulation of striated muscle contraction" EXACT []
synonym: "inhibition of striated muscle contraction" NARROW []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
relationship: negatively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045989
name: positive regulation of striated muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "activation of striated muscle contraction" NARROW []
synonym: "stimulation of striated muscle contraction" NARROW []
synonym: "up regulation of striated muscle contraction" EXACT []
synonym: "up-regulation of striated muscle contraction" EXACT []
synonym: "upregulation of striated muscle contraction" EXACT []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
relationship: positively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045990
name: carbon catabolite regulation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445]
synonym: "regulation of transcription by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:0031670 ! cellular response to nutrient

[Term]
id: GO:0045991
name: carbon catabolite activation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:mah, PMID:10559153]
synonym: "positive regulation of transcription by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:0045990 ! carbon catabolite regulation of transcription

[Term]
id: GO:0045992
name: negative regulation of embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "down regulation of embryonic development" EXACT []
synonym: "down-regulation of embryonic development" EXACT []
synonym: "downregulation of embryonic development" EXACT []
synonym: "inhibition of embryonic development" NARROW []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0009790 ! embryo development

[Term]
id: GO:0045993
name: negative regulation of translational initiation by iron
namespace: biological_process
def: "Any process involving iron that stops, prevents or reduces the rate of translational initiation." [GOC:go_curators]
synonym: "down regulation of translational initiation by iron" EXACT []
synonym: "down-regulation of translational initiation by iron" EXACT []
synonym: "downregulation of translational initiation by iron" EXACT []
synonym: "inhibition of translational initiation by iron" NARROW []
is_a: GO:0006447 ! regulation of translational initiation by iron
is_a: GO:0045947 ! negative regulation of translational initiation

[Term]
id: GO:0045994
name: positive regulation of translational initiation by iron
namespace: biological_process
def: "Any process involving iron that activates or increases the rate of translational initiation." [GOC:go_curators]
synonym: "activation of translational initiation by iron" NARROW []
synonym: "stimulation of translational initiation by iron" NARROW []
synonym: "up regulation of translational initiation by iron" EXACT []
synonym: "up-regulation of translational initiation by iron" EXACT []
synonym: "upregulation of translational initiation by iron" EXACT []
is_a: GO:0006447 ! regulation of translational initiation by iron
is_a: GO:0045948 ! positive regulation of translational initiation

[Term]
id: GO:0045995
name: regulation of embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0009790 ! embryo development

[Term]
id: GO:0045996
name: obsolete negative regulation of transcription by pheromones
namespace: biological_process
def: "OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription." [GOC:go_curators]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "down regulation of transcription by pheromones" EXACT []
synonym: "down-regulation of transcription by pheromones" EXACT []
synonym: "downregulation of transcription by pheromones" EXACT []
synonym: "inhibition of transcription by pheromones" NARROW []
is_obsolete: true

[Term]
id: GO:0045997
name: negative regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "down regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "downregulation of ecdysteroid biosynthetic process" EXACT []
synonym: "inhibition of ecdysteroid biosynthetic process" NARROW []
synonym: "negative regulation of ecdysteroid anabolism" EXACT []
synonym: "negative regulation of ecdysteroid biosynthesis" EXACT []
synonym: "negative regulation of ecdysteroid formation" EXACT []
synonym: "negative regulation of ecdysteroid synthesis" EXACT []
is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process
is_a: GO:0045965 ! negative regulation of ecdysteroid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
relationship: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0045998
name: positive regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "activation of ecdysteroid biosynthetic process" NARROW []
synonym: "positive regulation of ecdysteroid anabolism" EXACT []
synonym: "positive regulation of ecdysteroid biosynthesis" EXACT []
synonym: "positive regulation of ecdysteroid formation" EXACT []
synonym: "positive regulation of ecdysteroid synthesis" EXACT []
synonym: "stimulation of ecdysteroid biosynthetic process" NARROW []
synonym: "up regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "upregulation of ecdysteroid biosynthetic process" EXACT []
is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process
is_a: GO:0045966 ! positive regulation of ecdysteroid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
relationship: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0045999
name: negative regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators]
synonym: "down regulation of ecdysteroid secretion" EXACT []
synonym: "down-regulation of ecdysteroid secretion" EXACT []
synonym: "downregulation of ecdysteroid secretion" EXACT []
synonym: "inhibition of ecdysteroid secretion" NARROW []
is_a: GO:0007555 ! regulation of ecdysteroid secretion
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
relationship: negatively_regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0046000
name: positive regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators]
synonym: "activation of ecdysteroid secretion" NARROW []
synonym: "stimulation of ecdysteroid secretion" NARROW []
synonym: "up regulation of ecdysteroid secretion" EXACT []
synonym: "up-regulation of ecdysteroid secretion" EXACT []
synonym: "upregulation of ecdysteroid secretion" EXACT []
is_a: GO:0007555 ! regulation of ecdysteroid secretion
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
relationship: positively_regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0046001
name: negative regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle
is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic
relationship: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0046002
name: positive regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT []
is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle
is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic
relationship: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0046003
name: negative regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT []
is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle
is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic
relationship: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0046004
name: positive regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle
is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic
relationship: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0046005
name: positive regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "positive regulation of REM sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT []
is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep
is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep
relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0046006
name: regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activated T cell proliferation." [GOC:go_curators]
synonym: "regulation of activated T lymphocyte proliferation" EXACT []
synonym: "regulation of activated T-cell proliferation" EXACT []
synonym: "regulation of activated T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
relationship: regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0046007
name: negative regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation." [GOC:go_curators]
synonym: "down regulation of activated T cell proliferation" EXACT []
synonym: "down-regulation of activated T cell proliferation" EXACT []
synonym: "downregulation of activated T cell proliferation" EXACT []
synonym: "inhibition of activated T cell proliferation" NARROW []
synonym: "negative regulation of activated T lymphocyte proliferation" EXACT []
synonym: "negative regulation of activated T-cell proliferation" EXACT []
synonym: "negative regulation of activated T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046006 ! regulation of activated T cell proliferation
relationship: negatively_regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0046008
name: regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators]
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0046009
name: positive regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that increases the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators]
synonym: "activation of female receptivity, post-mating" NARROW []
synonym: "stimulation of female receptivity, post-mating" NARROW []
synonym: "up regulation of female receptivity, post-mating" EXACT []
synonym: "up-regulation of female receptivity, post-mating" EXACT []
synonym: "upregulation of female receptivity, post-mating" EXACT []
is_a: GO:0045925 ! positive regulation of female receptivity
is_a: GO:0046008 ! regulation of female receptivity, post-mating

[Term]
id: GO:0046010
name: positive regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "positive regulation of non-REM sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep
is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep
relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0046011
name: regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0046012
name: positive regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators]
synonym: "activation of oskar mRNA translation" NARROW []
synonym: "stimulation of oskar mRNA translation" NARROW []
synonym: "up regulation of oskar mRNA translation" EXACT []
synonym: "up-regulation of oskar mRNA translation" EXACT []
synonym: "upregulation of oskar mRNA translation" EXACT []
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0046011 ! regulation of oskar mRNA translation

[Term]
id: GO:0046013
name: regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "regulation of resting T cell proliferation" EXACT []
synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "regulation of T-cell homeostatic proliferation" EXACT []
synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
relationship: regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046014
name: negative regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "down regulation of T cell homeostatic proliferation" EXACT []
synonym: "down-regulation of T cell homeostatic proliferation" EXACT []
synonym: "downregulation of T cell homeostatic proliferation" EXACT []
synonym: "inhibition of T cell homeostatic proliferation" NARROW []
synonym: "negative regulation of resting T cell proliferation" EXACT []
synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "negative regulation of T-cell homeostatic proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046015
name: regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]
is_a: GO:0006355 ! regulation of DNA-templated transcription

[Term]
id: GO:0046016
name: positive regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that activates or increases the rate of transcription." [GOC:go_curators]
synonym: "activation of transcription by glucose" NARROW []
synonym: "stimulation of transcription by glucose" NARROW []
synonym: "up regulation of transcription by glucose" EXACT []
synonym: "up-regulation of transcription by glucose" EXACT []
synonym: "upregulation of transcription by glucose" EXACT []
is_a: GO:0045991 ! carbon catabolite activation of transcription
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0046017
name: obsolete regulation of transcription from RNA polymerase I promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "mitotic regulation of transcription from Pol I promoter" EXACT []
synonym: "regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0006356
consider: GO:0044772

[Term]
id: GO:0046018
name: obsolete positive regulation of transcription from RNA polymerase I promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "activation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription from Pol I promoter" EXACT []
synonym: "positive regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0044772
consider: GO:0045943

[Term]
id: GO:0046019
name: obsolete regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT []
is_obsolete: true

[Term]
id: GO:0046020
name: obsolete negative regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "down regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "negative regulation of transcription from Pol II promoter by pheromones" EXACT []
is_obsolete: true

[Term]
id: GO:0046021
name: obsolete regulation of transcription from RNA polymerase II promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "mitotic regulation of transcription from Pol II promoter" EXACT []
synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0006357
consider: GO:0044772

[Term]
id: GO:0046022
name: obsolete positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "activation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription from Pol II promoter" EXACT []
synonym: "positive regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0044772
consider: GO:0045944

[Term]
id: GO:0046023
name: obsolete regulation of transcription from RNA polymerase III promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "mitotic regulation of transcription from Pol III promoter" EXACT []
synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT []
synonym: "regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0006359
consider: GO:0044772

[Term]
id: GO:0046024
name: obsolete positive regulation of transcription from RNA polymerase III promoter during mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III that occurs during the mitotic cell cycle." [GOC:go_curators]
comment: The reason for obsoletion is that 'during' should be captured using an annotation extension.
synonym: "activation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription from Pol III promoter" EXACT []
synonym: "positive regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0044772
consider: GO:0045945

[Term]
id: GO:0046025
name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132]
synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132]
synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132]
synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" RELATED [EC:2.1.1.132]
xref: EC:2.1.1.132
xref: MetaCyc:2.1.1.132-RXN
xref: RHEA:17477
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046026
name: precorrin-4 C11-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133]
synonym: "CobM" RELATED [EC:2.1.1.133]
synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" RELATED [EC:2.1.1.133]
xref: EC:2.1.1.133
xref: MetaCyc:2.1.1.133-RXN
xref: RHEA:22012
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046027
name: phospholipid:diacylglycerol acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158]
synonym: "PDAT activity" RELATED [EC:2.3.1.158]
synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" RELATED [EC:2.3.1.158]
xref: EC:2.3.1.158
xref: MetaCyc:2.3.1.158-RXN
xref: RHEA:14057
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0046028
name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity
namespace: molecular_function
def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363]
synonym: "plastocyanin" NARROW []
is_a: GO:0009055 ! electron transfer activity

[Term]
id: GO:0046029
name: mannitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + H+ + NADH." [RHEA:15029]
synonym: "mannitol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.255]
synonym: "MTD activity" RELATED [EC:1.1.1.255]
synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255]
xref: EC:1.1.1.255
xref: KEGG_REACTION:R07135
xref: MetaCyc:1.1.1.255-RXN
xref: RHEA:15029
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0046030
name: inositol trisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf]
synonym: "IP(3) phosphatase activity" EXACT []
synonym: "IP3 phosphatase activity" EXACT []
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0046031
name: ADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators]
synonym: "ADP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046032
name: ADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators]
synonym: "ADP breakdown" EXACT []
synonym: "ADP catabolism" EXACT []
synonym: "ADP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0046033
name: AMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators]
synonym: "adenylate forming enzyme activity" RELATED []
synonym: "AMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046034
name: ATP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
synonym: "ATP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046035
name: CMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP, cytidine monophosphate." [GOC:go_curators]
synonym: "CMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046036
name: CTP metabolic process
namespace: biological_process
alt_id: GO:0006243
def: "The chemical reactions and pathways involving CTP, cytidine triphosphate." [GOC:go_curators]
synonym: "CTP deamination" NARROW []
synonym: "CTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046037
name: GMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GMP, guanosine monophosphate." [GOC:go_curators]
synonym: "GMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046038
name: GMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate." [GOC:go_curators]
synonym: "GMP breakdown" EXACT []
synonym: "GMP catabolism" EXACT []
synonym: "GMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046037 ! GMP metabolic process

[Term]
id: GO:0046039
name: GTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GTP, guanosine triphosphate." [GOC:go_curators]
synonym: "GTP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046040
name: IMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators]
synonym: "IMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046041
name: ITP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ITP, inosine triphosphate." [GOC:go_curators]
synonym: "ITP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046042
name: ITP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate." [GOC:go_curators]
synonym: "ITP anabolism" EXACT []
synonym: "ITP biosynthesis" EXACT []
synonym: "ITP formation" EXACT []
synonym: "ITP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046041 ! ITP metabolic process

[Term]
id: GO:0046043
name: TDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate." [GOC:go_curators]
synonym: "TDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046044
name: TMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate." [GOC:go_curators]
synonym: "TMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046045
name: TMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate." [GOC:go_curators]
synonym: "TMP breakdown" EXACT []
synonym: "TMP catabolism" EXACT []
synonym: "TMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046044 ! TMP metabolic process

[Term]
id: GO:0046046
name: TTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate." [GOC:go_curators]
synonym: "TTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046047
name: TTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate." [GOC:go_curators]
synonym: "TTP breakdown" EXACT []
synonym: "TTP catabolism" EXACT []
synonym: "TTP degradation" EXACT []
synonym: "TTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046046 ! TTP metabolic process

[Term]
id: GO:0046048
name: UDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate." [GOC:go_curators]
synonym: "UDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046049
name: UMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UMP, uridine monophosphate." [GOC:go_curators]
synonym: "UMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046050
name: UMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate." [GOC:go_curators]
synonym: "UMP breakdown" EXACT []
synonym: "UMP catabolism" EXACT []
synonym: "UMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046049 ! UMP metabolic process

[Term]
id: GO:0046051
name: UTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate." [GOC:go_curators]
synonym: "UTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046052
name: UTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators]
synonym: "UTP breakdown" EXACT []
synonym: "UTP catabolism" EXACT []
synonym: "UTP degradation" EXACT []
synonym: "UTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046051 ! UTP metabolic process

[Term]
id: GO:0046053
name: dAMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators]
synonym: "dAMP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046054
name: dGMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators]
synonym: "dGMP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046055
name: dGMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators]
synonym: "dGMP breakdown" EXACT []
synonym: "dGMP catabolism" EXACT []
synonym: "dGMP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046054 ! dGMP metabolic process

[Term]
id: GO:0046056
name: dADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators]
synonym: "dADP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046057
name: dADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators]
synonym: "dADP breakdown" EXACT []
synonym: "dADP catabolism" EXACT []
synonym: "dADP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0046058
name: cAMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators]
synonym: "3',5' cAMP metabolic process" EXACT []
synonym: "3',5' cAMP metabolism" EXACT []
synonym: "3',5'-cAMP metabolic process" EXACT []
synonym: "3',5'-cAMP metabolism" EXACT []
synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "cAMP generating peptide activity" RELATED []
synonym: "cAMP metabolism" EXACT []
synonym: "cyclic AMP metabolic process" EXACT []
synonym: "cyclic AMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0052652 ! cyclic purine nucleotide metabolic process

[Term]
id: GO:0046059
name: dAMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators]
synonym: "dAMP breakdown" EXACT []
synonym: "dAMP catabolism" EXACT []
synonym: "dAMP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046053 ! dAMP metabolic process

[Term]
id: GO:0046060
name: dATP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators]
synonym: "dATP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046061
name: dATP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators]
synonym: "dATP breakdown" EXACT []
synonym: "dATP catabolism" EXACT []
synonym: "dATP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046060 ! dATP metabolic process

[Term]
id: GO:0046062
name: dCDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate." [GOC:go_curators]
synonym: "dCDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046063
name: dCMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate." [GOC:go_curators]
synonym: "dCMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046064
name: dCMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate." [GOC:go_curators]
synonym: "dCMP anabolism" EXACT []
synonym: "dCMP biosynthesis" EXACT []
synonym: "dCMP formation" EXACT []
synonym: "dCMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046063 ! dCMP metabolic process

[Term]
id: GO:0046065
name: dCTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate." [GOC:go_curators]
synonym: "dCTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046066
name: dGDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators]
synonym: "dGDP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046067
name: dGDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators]
synonym: "dGDP breakdown" EXACT []
synonym: "dGDP catabolism" EXACT []
synonym: "dGDP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0046068
name: cGMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators]
synonym: "cGMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0052652 ! cyclic purine nucleotide metabolic process

[Term]
id: GO:0046069
name: cGMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators]
synonym: "cGMP breakdown" EXACT []
synonym: "cGMP catabolism" EXACT []
synonym: "cGMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009214 ! cyclic nucleotide catabolic process
is_a: GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0046070
name: dGTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGTP, guanosine triphosphate." [GOC:go_curators]
synonym: "dGTP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046071
name: dGTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate." [GOC:go_curators]
synonym: "dGTP anabolism" EXACT []
synonym: "dGTP biosynthesis" EXACT []
synonym: "dGTP formation" EXACT []
synonym: "dGTP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046070 ! dGTP metabolic process

[Term]
id: GO:0046072
name: dTDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate." [GOC:go_curators]
synonym: "dTDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046073
name: dTMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [GOC:go_curators]
synonym: "dTMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046074
name: dTMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate." [GOC:go_curators]
synonym: "dTMP breakdown" EXACT []
synonym: "dTMP catabolism" EXACT []
synonym: "dTMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046073 ! dTMP metabolic process

[Term]
id: GO:0046075
name: dTTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators]
synonym: "dTTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046076
name: dTTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators]
synonym: "dTTP breakdown" EXACT []
synonym: "dTTP catabolism" EXACT []
synonym: "dTTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046075 ! dTTP metabolic process

[Term]
id: GO:0046077
name: dUDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate." [GOC:go_curators]
synonym: "dUDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046078
name: dUMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate)." [GOC:go_curators]
synonym: "dUMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046079
name: dUMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate." [GOC:go_curators]
synonym: "dUMP breakdown" EXACT []
synonym: "dUMP catabolism" EXACT []
synonym: "dUMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046078 ! dUMP metabolic process

[Term]
id: GO:0046080
name: dUTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
synonym: "dUTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046081
name: dUTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
synonym: "dUTP breakdown" EXACT []
synonym: "dUTP catabolism" EXACT []
synonym: "dUTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046080 ! dUTP metabolic process

[Term]
id: GO:0046082
name: obsolete 5-methylcytosine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators]
comment: This term was obsoleted because itis redundant with DNA methylation-dependent heterochromatin formation ; GO:0006346 or its children.
synonym: "5-methylcytosine anabolism" EXACT []
synonym: "5-methylcytosine biosynthesis" EXACT []
synonym: "5-methylcytosine formation" EXACT []
synonym: "5-methylcytosine synthesis" EXACT []
is_obsolete: true
consider: GO:0006346

[Term]
id: GO:0046083
name: adenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]
synonym: "adenine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046084
name: adenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]
synonym: "adenine anabolism" EXACT []
synonym: "adenine biosynthesis" EXACT []
synonym: "adenine formation" EXACT []
synonym: "adenine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046083 ! adenine metabolic process

[Term]
id: GO:0046085
name: adenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
synonym: "adenosine metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046086
name: adenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
synonym: "adenosine anabolism" EXACT []
synonym: "adenosine biosynthesis" EXACT []
synonym: "adenosine formation" EXACT []
synonym: "adenosine synthesis" EXACT []
is_a: GO:0046085 ! adenosine metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0046087
name: cytidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators]
synonym: "cytidine metabolism" EXACT []
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046088
name: cytidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators]
synonym: "cytidine anabolism" EXACT []
synonym: "cytidine biosynthesis" EXACT []
synonym: "cytidine formation" EXACT []
synonym: "cytidine synthesis" EXACT []
is_a: GO:0046087 ! cytidine metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0046089
name: cytosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators]
synonym: "cytosine anabolism" EXACT []
synonym: "cytosine biosynthesis" EXACT []
synonym: "cytosine formation" EXACT []
synonym: "cytosine synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process
is_a: GO:0019858 ! cytosine metabolic process

[Term]
id: GO:0046090
name: deoxyadenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxyadenosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046091
name: deoxyadenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxyadenosine anabolism" EXACT []
synonym: "deoxyadenosine biosynthesis" EXACT []
synonym: "deoxyadenosine formation" EXACT []
synonym: "deoxyadenosine synthesis" EXACT []
is_a: GO:0046090 ! deoxyadenosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046092
name: deoxycytidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxycytidine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046093
name: deoxycytidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxycytidine anabolism" EXACT []
synonym: "deoxycytidine biosynthesis" EXACT []
synonym: "deoxycytidine formation" EXACT []
synonym: "deoxycytidine synthesis" EXACT []
is_a: GO:0046092 ! deoxycytidine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046094
name: deoxyinosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
synonym: "deoxyinosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046095
name: deoxyinosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
synonym: "deoxyinosine anabolism" EXACT []
synonym: "deoxyinosine biosynthesis" EXACT []
synonym: "deoxyinosine formation" EXACT []
synonym: "deoxyinosine synthesis" EXACT []
is_a: GO:0046094 ! deoxyinosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046096
name: deoxyuridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxyuridine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046097
name: deoxyuridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
synonym: "deoxyuridine anabolism" EXACT []
synonym: "deoxyuridine biosynthesis" EXACT []
synonym: "deoxyuridine formation" EXACT []
synonym: "deoxyuridine synthesis" EXACT []
is_a: GO:0046096 ! deoxyuridine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046098
name: guanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
synonym: "guanine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046099
name: guanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
synonym: "guanine anabolism" EXACT []
synonym: "guanine biosynthesis" EXACT []
synonym: "guanine formation" EXACT []
synonym: "guanine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0046100
name: hypoxanthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
synonym: "hypoxanthine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046101
name: hypoxanthine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
synonym: "hypoxanthine anabolism" EXACT []
synonym: "hypoxanthine biosynthesis" EXACT []
synonym: "hypoxanthine formation" EXACT []
synonym: "hypoxanthine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046100 ! hypoxanthine metabolic process

[Term]
id: GO:0046102
name: inosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
synonym: "inosine metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046103
name: inosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
synonym: "inosine anabolism" EXACT []
synonym: "inosine biosynthesis" EXACT []
synonym: "inosine formation" EXACT []
synonym: "inosine synthesis" EXACT []
is_a: GO:0046102 ! inosine metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0046104
name: thymidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
synonym: "deoxyribosylthymine metabolic process" EXACT []
synonym: "deoxyribosylthymine metabolism" EXACT []
synonym: "thymidine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046105
name: thymidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
synonym: "deoxyribosylthymine biosynthesis" EXACT []
synonym: "deoxyribosylthymine biosynthetic process" EXACT []
synonym: "thymidine anabolism" EXACT []
synonym: "thymidine biosynthesis" EXACT []
synonym: "thymidine formation" EXACT []
synonym: "thymidine synthesis" EXACT []
is_a: GO:0046104 ! thymidine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046106
name: thymine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
synonym: "thymine anabolism" EXACT []
synonym: "thymine biosynthesis" EXACT []
synonym: "thymine formation" EXACT []
synonym: "thymine synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process
is_a: GO:0019859 ! thymine metabolic process

[Term]
id: GO:0046107
name: uracil biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
synonym: "uracil anabolism" EXACT []
synonym: "uracil biosynthesis" EXACT []
synonym: "uracil formation" EXACT []
synonym: "uracil synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process
is_a: GO:0019860 ! uracil metabolic process

[Term]
id: GO:0046108
name: uridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
synonym: "uridine metabolism" EXACT []
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046109
name: uridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
synonym: "uridine anabolism" EXACT []
synonym: "uridine biosynthesis" EXACT []
synonym: "uridine formation" EXACT []
synonym: "uridine synthesis" EXACT []
is_a: GO:0046108 ! uridine metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0046110
name: xanthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
synonym: "xanthine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046111
name: xanthine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
synonym: "xanthine anabolism" EXACT []
synonym: "xanthine biosynthesis" EXACT []
synonym: "xanthine formation" EXACT []
synonym: "xanthine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046110 ! xanthine metabolic process

[Term]
id: GO:0046112
name: nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
synonym: "nucleobase anabolism" EXACT []
synonym: "nucleobase biosynthesis" EXACT []
synonym: "nucleobase formation" EXACT []
synonym: "nucleobase synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009112 ! nucleobase metabolic process

[Term]
id: GO:0046113
name: nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
synonym: "nucleobase breakdown" EXACT []
synonym: "nucleobase catabolism" EXACT []
synonym: "nucleobase degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0009112 ! nucleobase metabolic process

[Term]
id: GO:0046114
name: guanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators]
synonym: "guanosine anabolism" EXACT []
synonym: "guanosine biosynthesis" EXACT []
synonym: "guanosine formation" EXACT []
synonym: "guanosine synthesis" EXACT []
is_a: GO:0008617 ! guanosine metabolic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0046115
name: guanosine catabolic process
namespace: biological_process
alt_id: GO:0006160
def: "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators]
synonym: "guanosine breakdown" EXACT []
synonym: "guanosine catabolism" EXACT []
synonym: "guanosine degradation" EXACT []
synonym: "guanosine phosphorolysis" RELATED []
is_a: GO:0008617 ! guanosine metabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0046116
name: queuosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732]
synonym: "queuosine metabolism" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process

[Term]
id: GO:0046117
name: queuosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732]
synonym: "queuosine breakdown" EXACT []
synonym: "queuosine catabolism" EXACT []
synonym: "queuosine degradation" EXACT []
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046116 ! queuosine metabolic process

[Term]
id: GO:0046118
name: 7-methylguanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732]
synonym: "7-methylguanosine anabolism" EXACT []
synonym: "7-methylguanosine biosynthesis" EXACT []
synonym: "7-methylguanosine formation" EXACT []
synonym: "7-methylguanosine synthesis" EXACT []
is_a: GO:0008618 ! 7-methylguanosine metabolic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0046119
name: 7-methylguanosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732]
synonym: "7-methylguanosine breakdown" EXACT []
synonym: "7-methylguanosine catabolism" EXACT []
synonym: "7-methylguanosine degradation" EXACT []
is_a: GO:0008618 ! 7-methylguanosine metabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0046120
name: deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "deoxyribonucleoside anabolism" EXACT []
synonym: "deoxyribonucleoside biosynthesis" EXACT []
synonym: "deoxyribonucleoside formation" EXACT []
synonym: "deoxyribonucleoside synthesis" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process

[Term]
id: GO:0046121
name: deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "deoxyribonucleoside breakdown" EXACT []
synonym: "deoxyribonucleoside catabolism" EXACT []
synonym: "deoxyribonucleoside degradation" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process

[Term]
id: GO:0046122
name: purine deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "purine deoxyribonucleoside metabolism" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0046123
name: purine deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "purine deoxyribonucleoside anabolism" EXACT []
synonym: "purine deoxyribonucleoside biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside formation" EXACT []
synonym: "purine deoxyribonucleoside synthesis" EXACT []
is_a: GO:0042451 ! purine nucleoside biosynthetic process
is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046124
name: purine deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "purine deoxyribonucleoside breakdown" EXACT []
synonym: "purine deoxyribonucleoside catabolism" EXACT []
synonym: "purine deoxyribonucleoside degradation" EXACT []
is_a: GO:0006152 ! purine nucleoside catabolic process
is_a: GO:0046121 ! deoxyribonucleoside catabolic process
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046125
name: pyrimidine deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "pyrimidine deoxyribonucleoside metabolism" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009120 ! deoxyribonucleoside metabolic process

[Term]
id: GO:0046126
name: pyrimidine deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "pyrimidine deoxyribonucleoside anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside synthesis" EXACT []
is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0046127
name: pyrimidine deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "pyrimidine deoxyribonucleoside breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside degradation" EXACT []
is_a: GO:0046121 ! deoxyribonucleoside catabolic process
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process

[Term]
id: GO:0046128
name: purine ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
synonym: "purine ribonucleoside metabolism" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0046129
name: purine ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
synonym: "purine ribonucleoside anabolism" EXACT []
synonym: "purine ribonucleoside biosynthesis" EXACT []
synonym: "purine ribonucleoside formation" EXACT []
synonym: "purine ribonucleoside synthesis" EXACT []
is_a: GO:0042451 ! purine nucleoside biosynthetic process
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046130
name: purine ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
synonym: "purine ribonucleoside breakdown" EXACT []
synonym: "purine ribonucleoside catabolism" EXACT []
synonym: "purine ribonucleoside degradation" EXACT []
is_a: GO:0006152 ! purine nucleoside catabolic process
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046131
name: pyrimidine ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
synonym: "pyrimidine ribonucleoside metabolism" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009119 ! ribonucleoside metabolic process

[Term]
id: GO:0046132
name: pyrimidine ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
synonym: "pyrimidine ribonucleoside anabolism" EXACT []
synonym: "pyrimidine ribonucleoside biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside formation" EXACT []
synonym: "pyrimidine ribonucleoside synthesis" EXACT []
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0046133
name: pyrimidine ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
synonym: "pyrimidine ribonucleoside breakdown" EXACT []
synonym: "pyrimidine ribonucleoside catabolism" EXACT []
synonym: "pyrimidine ribonucleoside degradation" EXACT []
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process

[Term]
id: GO:0046134
name: pyrimidine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "pyrimidine nucleoside anabolism" EXACT []
synonym: "pyrimidine nucleoside biosynthesis" EXACT []
synonym: "pyrimidine nucleoside formation" EXACT []
synonym: "pyrimidine nucleoside synthesis" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0046135
name: pyrimidine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai]
synonym: "pyrimidine nucleoside breakdown" EXACT []
synonym: "pyrimidine nucleoside catabolism" EXACT []
synonym: "pyrimidine nucleoside degradation" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0046136
name: positive regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
synonym: "activation of vitamin metabolic process" NARROW []
synonym: "positive regulation of vitamin metabolism" EXACT []
synonym: "stimulation of vitamin metabolic process" NARROW []
synonym: "up regulation of vitamin metabolic process" EXACT []
synonym: "up-regulation of vitamin metabolic process" EXACT []
synonym: "upregulation of vitamin metabolic process" EXACT []
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0046137
name: negative regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
synonym: "down regulation of vitamin metabolic process" EXACT []
synonym: "down-regulation of vitamin metabolic process" EXACT []
synonym: "downregulation of vitamin metabolic process" EXACT []
synonym: "inhibition of vitamin metabolic process" NARROW []
synonym: "negative regulation of vitamin metabolism" EXACT []
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0046138
name: obsolete coenzyme and prosthetic group biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group anabolism" EXACT []
synonym: "coenzyme and prosthetic group biosynthesis" EXACT []
synonym: "coenzyme and prosthetic group biosynthetic process" EXACT []
synonym: "coenzyme and prosthetic group formation" EXACT []
synonym: "coenzyme and prosthetic group synthesis" EXACT []
is_obsolete: true
consider: GO:0051191

[Term]
id: GO:0046139
name: obsolete coenzyme and prosthetic group catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group breakdown" EXACT []
synonym: "coenzyme and prosthetic group catabolic process" EXACT []
synonym: "coenzyme and prosthetic group catabolism" EXACT []
synonym: "coenzyme and prosthetic group degradation" EXACT []
is_obsolete: true
consider: GO:0051190

[Term]
id: GO:0046140
name: corrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai]
synonym: "corrin anabolism" EXACT []
synonym: "corrin biosynthesis" EXACT []
synonym: "corrin formation" EXACT []
synonym: "corrin synthesis" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:0046141
name: corrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai]
synonym: "corrin breakdown" EXACT []
synonym: "corrin catabolism" EXACT []
synonym: "corrin degradation" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process

[Term]
id: GO:0046142
name: obsolete negative regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0046143
name: obsolete positive regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0046144
name: obsolete D-alanine family amino acid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving D-alanine and related amino acids." [GOC:ai]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "D-alanine family amino acid metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0046145
name: obsolete D-alanine family amino acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids." [GOC:ai]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "D-alanine family amino acid anabolism" EXACT []
synonym: "D-alanine family amino acid biosynthesis" EXACT []
synonym: "D-alanine family amino acid formation" EXACT []
synonym: "D-alanine family amino acid synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0046146
name: tetrahydrobiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [PMID:21871890]
synonym: "5,6,7,8-tetrahydrobiopterin metabolic process" EXACT [GOC:curators]
synonym: "tetrahydrobiopterin metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0046147
name: tetrahydrobiopterin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]
synonym: "5,6,7,8-tetrahydrobiopterin catabolic process" EXACT [Wikipedia:Tetrahydrobiopterin]
synonym: "tetrahydrobiopterin breakdown" EXACT []
synonym: "tetrahydrobiopterin catabolism" EXACT []
synonym: "tetrahydrobiopterin degradation" EXACT []
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process

[Term]
id: GO:0046148
name: pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]
synonym: "pigment anabolism" EXACT []
synonym: "pigment biosynthesis" EXACT []
synonym: "pigment formation" EXACT []
synonym: "pigment synthesis" EXACT []
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0046149
name: pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]
synonym: "pigment breakdown" EXACT []
synonym: "pigment catabolism" EXACT []
synonym: "pigment degradation" EXACT []
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0046150
name: melanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [ISBN:0198506732]
synonym: "melanin breakdown" EXACT []
synonym: "melanin catabolism" EXACT []
synonym: "melanin degradation" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0046151
name: eye pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment breakdown" EXACT []
synonym: "eye pigment catabolism" EXACT []
synonym: "eye pigment degradation" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0046152
name: ommochrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
synonym: "ommochrome metabolism" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046158 ! ocellus pigment metabolic process

[Term]
id: GO:0046153
name: ommochrome catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
synonym: "ommochrome breakdown" EXACT []
synonym: "ommochrome catabolism" EXACT []
synonym: "ommochrome degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0046151 ! eye pigment catabolic process
is_a: GO:0046152 ! ommochrome metabolic process
is_a: GO:0046159 ! ocellus pigment catabolic process

[Term]
id: GO:0046154
name: rhodopsin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
synonym: "rhodopsin metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0042441 ! eye pigment metabolic process

[Term]
id: GO:0046155
name: rhodopsin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
synonym: "rhodopsin breakdown" EXACT []
synonym: "rhodopsin catabolism" EXACT []
synonym: "rhodopsin degradation" EXACT []
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0046151 ! eye pigment catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0046156
name: siroheme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732]
synonym: "sirohaem metabolic process" EXACT []
synonym: "sirohaem metabolism" EXACT []
synonym: "siroheme metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046157
name: siroheme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732]
synonym: "sirohaem catabolic process" EXACT []
synonym: "sirohaem catabolism" EXACT []
synonym: "siroheme breakdown" EXACT []
synonym: "siroheme catabolism" EXACT []
synonym: "siroheme degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046156 ! siroheme metabolic process

[Term]
id: GO:0046158
name: ocellus pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706]
synonym: "ocellus pigment metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0043474 ! pigment metabolic process involved in pigmentation
relationship: part_of GO:0033060 ! ocellus pigmentation

[Term]
id: GO:0046159
name: ocellus pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706]
synonym: "ocellus pigment breakdown" EXACT []
synonym: "ocellus pigment catabolism" EXACT []
synonym: "ocellus pigment degradation" EXACT []
is_a: GO:0046149 ! pigment catabolic process
is_a: GO:0046158 ! ocellus pigment metabolic process

[Term]
id: GO:0046160
name: heme a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3." [GOC:curators]
synonym: "haem a metabolic process" EXACT []
synonym: "haem a metabolism" EXACT []
synonym: "heme a metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046161
name: heme a catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3." [GOC:curators, PMID:28352909]
synonym: "haem a catabolic process" EXACT []
synonym: "haem a catabolism" EXACT []
synonym: "heme a breakdown" EXACT []
synonym: "heme a catabolism" EXACT []
synonym: "heme a degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046160 ! heme a metabolic process

[Term]
id: GO:0046162
name: heme C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators]
synonym: "haem C metabolic process" EXACT []
synonym: "haem C metabolism" EXACT []
synonym: "heme C metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046163
name: heme C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme C, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators]
synonym: "haem C catabolic process" EXACT []
synonym: "haem C catabolism" EXACT []
synonym: "heme C breakdown" EXACT []
synonym: "heme C catabolism" EXACT []
synonym: "heme C degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046162 ! heme C metabolic process

[Term]
id: GO:0046164
name: alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]
synonym: "alcohol breakdown" EXACT []
synonym: "alcohol catabolism" EXACT []
synonym: "alcohol degradation" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0046165
name: alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]
synonym: "alcohol anabolism" EXACT []
synonym: "alcohol biosynthesis" EXACT []
synonym: "alcohol formation" EXACT []
synonym: "alcohol synthesis" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0046166
name: glyceraldehyde-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai]
synonym: "glyceraldehyde 3-phosphate biosynthesis" EXACT []
synonym: "glyceraldehyde 3-phosphate biosynthetic process" EXACT []
synonym: "glyceraldehyde-3-phosphate anabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate biosynthesis" EXACT []
synonym: "glyceraldehyde-3-phosphate formation" EXACT []
synonym: "glyceraldehyde-3-phosphate synthesis" EXACT []
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046167
name: glycerol-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
synonym: "glycerol-3-phosphate anabolism" EXACT []
synonym: "glycerol-3-phosphate biosynthesis" EXACT []
synonym: "glycerol-3-phosphate formation" EXACT []
synonym: "glycerol-3-phosphate synthesis" EXACT []
is_a: GO:0006072 ! glycerol-3-phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046168
name: glycerol-3-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
synonym: "glycerol-3-phosphate breakdown" EXACT []
synonym: "glycerol-3-phosphate catabolism" EXACT []
synonym: "glycerol-3-phosphate degradation" EXACT []
is_a: GO:0006072 ! glycerol-3-phosphate metabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0046169
name: methanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai]
synonym: "methanol anabolism" EXACT []
synonym: "methanol biosynthesis" EXACT []
synonym: "methanol formation" EXACT []
synonym: "methanol synthesis" EXACT []
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process

[Term]
id: GO:0046170
name: methanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai]
synonym: "methanol breakdown" EXACT []
synonym: "methanol catabolism" EXACT []
synonym: "methanol degradation" EXACT []
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process

[Term]
id: GO:0046171
name: octanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai]
synonym: "octanol anabolism" EXACT []
synonym: "octanol biosynthesis" EXACT []
synonym: "octanol formation" EXACT []
synonym: "octanol synthesis" EXACT []
is_a: GO:0006070 ! octanol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1903175 ! fatty alcohol biosynthetic process

[Term]
id: GO:0046172
name: octanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai]
synonym: "octanol breakdown" EXACT []
synonym: "octanol catabolism" EXACT []
synonym: "octanol degradation" EXACT []
is_a: GO:0006070 ! octanol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:1903174 ! fatty alcohol catabolic process

[Term]
id: GO:0046173
name: polyol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]
synonym: "polyhydric alcohol biosynthetic process" EXACT []
synonym: "polyol anabolism" EXACT []
synonym: "polyol biosynthesis" EXACT []
synonym: "polyol formation" EXACT []
synonym: "polyol synthesis" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0046174
name: polyol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]
synonym: "polyhydric alcohol catabolic process" EXACT []
synonym: "polyol breakdown" EXACT []
synonym: "polyol catabolism" EXACT []
synonym: "polyol degradation" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0046175
name: aldonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732]
synonym: "aldonic acid anabolism" EXACT []
synonym: "aldonic acid biosynthesis" EXACT []
synonym: "aldonic acid formation" EXACT []
synonym: "aldonic acid synthesis" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046176
name: aldonic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732]
synonym: "aldonic acid breakdown" EXACT []
synonym: "aldonic acid catabolism" EXACT []
synonym: "aldonic acid degradation" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046177
name: D-gluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732]
synonym: "D-gluconate breakdown" EXACT []
synonym: "D-gluconate catabolism" EXACT []
synonym: "D-gluconate degradation" EXACT []
xref: MetaCyc:GLUCONSUPER-PWY
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019521 ! D-gluconate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046178
name: D-gluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732]
synonym: "D-gluconate anabolism" EXACT []
synonym: "D-gluconate biosynthesis" EXACT []
synonym: "D-gluconate formation" EXACT []
synonym: "D-gluconate synthesis" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0019521 ! D-gluconate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046179
name: keto-D-gluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732]
synonym: "keto-D-gluconate anabolism" EXACT []
synonym: "keto-D-gluconate biosynthesis" EXACT []
synonym: "keto-D-gluconate formation" EXACT []
synonym: "keto-D-gluconate synthesis" EXACT []
is_a: GO:0019525 ! keto-D-gluconate metabolic process
is_a: GO:0046180 ! ketogluconate biosynthetic process

[Term]
id: GO:0046180
name: ketogluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732]
synonym: "ketogluconate anabolism" EXACT []
synonym: "ketogluconate biosynthesis" EXACT []
synonym: "ketogluconate formation" EXACT []
synonym: "ketogluconate synthesis" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046181
name: ketogluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732]
synonym: "ketogluconate breakdown" EXACT []
synonym: "ketogluconate catabolism" EXACT []
synonym: "ketogluconate degradation" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046182
name: L-idonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:curators]
synonym: "L-idonate anabolism" EXACT []
synonym: "L-idonate biosynthesis" EXACT []
synonym: "L-idonate formation" EXACT []
synonym: "L-idonate synthesis" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0019523 ! L-idonate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046183
name: L-idonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:curators]
synonym: "L-idonate breakdown" EXACT []
synonym: "L-idonate catabolism" EXACT []
synonym: "L-idonate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019523 ! L-idonate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046184
name: aldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]
synonym: "aldehyde anabolism" EXACT []
synonym: "aldehyde biosynthesis" EXACT []
synonym: "aldehyde formation" EXACT []
synonym: "aldehyde synthesis" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0046185
name: aldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]
synonym: "aldehyde breakdown" EXACT []
synonym: "aldehyde catabolism" EXACT []
synonym: "aldehyde degradation" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0046186
name: acetaldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai]
synonym: "acetaldehyde anabolism" EXACT []
synonym: "acetaldehyde biosynthesis" EXACT []
synonym: "acetaldehyde formation" EXACT []
synonym: "acetaldehyde synthesis" EXACT []
is_a: GO:0006117 ! acetaldehyde metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0046187
name: acetaldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai]
synonym: "acetaldehyde breakdown" EXACT []
synonym: "acetaldehyde catabolism" EXACT []
synonym: "acetaldehyde degradation" EXACT []
is_a: GO:0006117 ! acetaldehyde metabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0046188
name: methane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai]
synonym: "methane breakdown" EXACT []
synonym: "methane catabolism" EXACT []
synonym: "methane degradation" EXACT []
is_a: GO:0015947 ! methane metabolic process
is_a: GO:0043448 ! alkane catabolic process

[Term]
id: GO:0046189
name: phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai]
synonym: "phenol-containing compound anabolism" EXACT []
synonym: "phenol-containing compound biosynthesis" EXACT []
synonym: "phenol-containing compound formation" EXACT []
synonym: "phenol-containing compound synthesis" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0046190
name: aerobic phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai]
synonym: "aerobic phenol-containing compound anabolism" EXACT []
synonym: "aerobic phenol-containing compound biosynthesis" EXACT []
synonym: "aerobic phenol-containing compound formation" EXACT []
synonym: "aerobic phenol-containing compound synthesis" EXACT []
is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0046191
name: aerobic phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai]
synonym: "aerobic phenol-containing compound breakdown" EXACT []
synonym: "aerobic phenol-containing compound catabolism" EXACT []
synonym: "aerobic phenol-containing compound degradation" EXACT []
is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process

[Term]
id: GO:0046192
name: anaerobic phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai]
synonym: "anaerobic phenol-containing compound anabolism" EXACT []
synonym: "anaerobic phenol-containing compound biosynthesis" EXACT []
synonym: "anaerobic phenol-containing compound formation" EXACT []
synonym: "anaerobic phenol-containing compound synthesis" EXACT []
is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0046193
name: anaerobic phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai]
synonym: "anaerobic phenol-containing compound breakdown" EXACT []
synonym: "anaerobic phenol-containing compound catabolism" EXACT []
synonym: "anaerobic phenol-containing compound degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process

[Term]
id: GO:0046194
name: obsolete pentachlorophenol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:ai]
comment: This term was made obsolete because pentachlorophenol is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "pentachlorophenol anabolism" EXACT []
synonym: "pentachlorophenol biosynthesis" EXACT []
synonym: "pentachlorophenol biosynthetic process" EXACT []
synonym: "pentachlorophenol formation" EXACT []
synonym: "pentachlorophenol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018961

[Term]
id: GO:0046195
name: obsolete 4-nitrophenol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai]
comment: This term was made obsolete because 4-nitrophenol is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-nitrophenol anabolism" EXACT []
synonym: "4-nitrophenol biosynthesis" EXACT []
synonym: "4-nitrophenol biosynthetic process" EXACT []
synonym: "4-nitrophenol formation" EXACT []
synonym: "4-nitrophenol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018960

[Term]
id: GO:0046196
name: 4-nitrophenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai]
synonym: "4-nitrophenol breakdown" EXACT []
synonym: "4-nitrophenol catabolism" EXACT []
synonym: "4-nitrophenol degradation" EXACT []
is_a: GO:0018960 ! 4-nitrophenol metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046197
name: orcinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:ai]
synonym: "orcinol anabolism" EXACT []
synonym: "orcinol biosynthesis" EXACT []
synonym: "orcinol formation" EXACT []
synonym: "orcinol synthesis" EXACT []
is_a: GO:0018940 ! orcinol metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0046198
name: obsolete cresol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai]
comment: This term was made obsolete because cresol is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "cresol anabolism" EXACT []
synonym: "cresol biosynthesis" EXACT []
synonym: "cresol biosynthetic process" EXACT []
synonym: "cresol formation" EXACT []
synonym: "cresol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0042212

[Term]
id: GO:0046199
name: cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai]
synonym: "cresol breakdown" EXACT []
synonym: "cresol catabolism" EXACT []
synonym: "cresol degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042212 ! cresol metabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0046200
name: obsolete m-cresol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:ai]
comment: This term was made obsolete because m-cresol is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "m-cresol anabolism" EXACT []
synonym: "m-cresol biosynthesis" EXACT []
synonym: "m-cresol biosynthetic process" EXACT []
synonym: "m-cresol formation" EXACT []
synonym: "m-cresol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018925

[Term]
id: GO:0046201
name: cyanate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid." [GOC:ai]
synonym: "cyanate anabolism" EXACT []
synonym: "cyanate biosynthesis" EXACT []
synonym: "cyanate formation" EXACT []
synonym: "cyanate synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009439 ! cyanate metabolic process

[Term]
id: GO:0046202
name: cyanide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [GOC:ai]
synonym: "cyanide anabolism" EXACT []
synonym: "cyanide biosynthesis" EXACT []
synonym: "cyanide formation" EXACT []
synonym: "cyanide synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0019499 ! cyanide metabolic process

[Term]
id: GO:0046203
name: spermidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
synonym: "spermidine breakdown" EXACT []
synonym: "spermidine catabolism" EXACT []
synonym: "spermidine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0046204
name: nor-spermidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
synonym: "nor-spermidine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0046205
name: nor-spermidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
synonym: "nor-spermidine breakdown" EXACT []
synonym: "nor-spermidine catabolism" EXACT []
synonym: "nor-spermidine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0046204 ! nor-spermidine metabolic process

[Term]
id: GO:0046206
name: trypanothione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai]
synonym: "trypanothione metabolism" EXACT []
is_a: GO:1901685 ! glutathione derivative metabolic process

[Term]
id: GO:0046207
name: trypanothione catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai]
synonym: "trypanothione breakdown" EXACT []
synonym: "trypanothione catabolism" EXACT []
synonym: "trypanothione degradation" EXACT []
is_a: GO:0046206 ! trypanothione metabolic process
is_a: GO:1901686 ! glutathione derivative catabolic process

[Term]
id: GO:0046208
name: spermine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [PMID:12141946]
synonym: "spermine breakdown" EXACT []
synonym: "spermine catabolism" EXACT []
synonym: "spermine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0046209
name: nitric oxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
synonym: "nitric oxide metabolism" EXACT []
is_a: GO:2001057 ! reactive nitrogen species metabolic process

[Term]
id: GO:0046210
name: nitric oxide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
synonym: "nitric oxide breakdown" EXACT []
synonym: "nitric oxide catabolism" EXACT []
synonym: "nitric oxide degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:0046211
name: (+)-camphor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone. Consists of the three reactions: (2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate, which is converted to (1R,2S,4R)-borneol + diphosphate, and then to (1R,4R)-camphor." [GOC:ai, PMID:42357]
synonym: "(+)-camphor anabolism" EXACT []
synonym: "(+)-camphor biosynthesis" EXACT []
synonym: "(+)-camphor formation" EXACT []
synonym: "(+)-camphor synthesis" EXACT []
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0018882 ! (+)-camphor metabolic process
is_a: GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0046212
name: obsolete methyl ethyl ketone biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [GOC:ai]
comment: This term was made obsolete because methyl ethyl ketone is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "methyl ethyl ketone anabolism" EXACT []
synonym: "methyl ethyl ketone biosynthesis" EXACT []
synonym: "methyl ethyl ketone biosynthetic process" EXACT []
synonym: "methyl ethyl ketone formation" EXACT []
synonym: "methyl ethyl ketone synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018928

[Term]
id: GO:0046213
name: methyl ethyl ketone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor." [GOC:ai]
synonym: "methyl ethyl ketone breakdown" EXACT []
synonym: "methyl ethyl ketone catabolism" EXACT []
synonym: "methyl ethyl ketone degradation" EXACT []
is_a: GO:0018928 ! methyl ethyl ketone metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0046214
name: enterobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:ai]
synonym: "enterobactin breakdown" EXACT []
synonym: "enterobactin catabolism" EXACT []
synonym: "enterobactin degradation" EXACT []
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:1901335 ! lactone catabolic process

[Term]
id: GO:0046215
name: siderophore catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:ai]
synonym: "siderochrome catabolism" NARROW []
synonym: "siderophore breakdown" EXACT []
synonym: "siderophore catabolism" EXACT []
synonym: "siderophore degradation" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0046216
name: indole phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai]
synonym: "indole phytoalexin breakdown" EXACT []
synonym: "indole phytoalexin catabolism" EXACT []
synonym: "indole phytoalexin degradation" EXACT []
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0046217 ! indole phytoalexin metabolic process
is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046217
name: indole phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai]
synonym: "indole phytoalexin metabolism" EXACT []
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0046218
name: obsolete indolalkylamine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "indolalkylamine breakdown" EXACT []
synonym: "indolalkylamine catabolism" EXACT []
synonym: "indolalkylamine degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0046219
name: indolalkylamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators]
synonym: "indolalkylamine anabolism" EXACT []
synonym: "indolalkylamine biosynthesis" EXACT []
synonym: "indolalkylamine formation" EXACT []
synonym: "indolalkylamine synthesis" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0042401 ! biogenic amine biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process

[Term]
id: GO:0046220
name: pyridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai]
synonym: "pyridine anabolism" EXACT []
synonym: "pyridine biosynthesis" EXACT []
synonym: "pyridine formation" EXACT []
synonym: "pyridine synthesis" EXACT []
is_a: GO:0019507 ! pyridine metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0046221
name: pyridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai]
synonym: "pyridine breakdown" EXACT []
synonym: "pyridine catabolism" EXACT []
synonym: "pyridine degradation" EXACT []
is_a: GO:0019507 ! pyridine metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0046222
name: aflatoxin metabolic process
namespace: biological_process
alt_id: GO:0043389
alt_id: GO:0043390
alt_id: GO:0043391
def: "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai]
synonym: "aflatoxin B metabolic process" NARROW [GOC:mah]
synonym: "aflatoxin B1 metabolic process" RELATED []
synonym: "aflatoxin B1 metabolism" RELATED []
synonym: "aflatoxin B2 metabolic process" RELATED []
synonym: "aflatoxin B2 metabolism" RELATED []
synonym: "aflatoxin metabolism" EXACT []
is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:0046223
name: aflatoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai, PMID:20807200]
synonym: "aflatoxin breakdown" EXACT []
synonym: "aflatoxin catabolism" EXACT []
synonym: "aflatoxin degradation" EXACT []
is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0046222 ! aflatoxin metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process

[Term]
id: GO:0046224
name: bacteriocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai]
synonym: "bacteriocin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0030650 ! peptide antibiotic metabolic process

[Term]
id: GO:0046225
name: bacteriocin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai]
synonym: "bacteriocin breakdown" EXACT []
synonym: "bacteriocin catabolism" EXACT []
synonym: "bacteriocin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0030652 ! peptide antibiotic catabolic process
is_a: GO:0046224 ! bacteriocin metabolic process
is_a: GO:0051410 ! detoxification of nitrogen compound

[Term]
id: GO:0046226
name: coumarin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:ai]
synonym: "coumarin breakdown" EXACT []
synonym: "coumarin catabolism" EXACT []
synonym: "coumarin degradation" EXACT []
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046227
name: obsolete 2,4,5-trichlorophenoxyacetic acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai]
comment: This term was made obsolete because 2,4,5-trichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2,4,5-trichlorophenoxyacetic acid anabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid biosynthesis" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid biosynthetic process" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid formation" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018980

[Term]
id: GO:0046228
name: 2,4,5-trichlorophenoxyacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai]
synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT []
is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0046229
name: obsolete 2-aminobenzenesulfonate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai]
comment: This term was made obsolete because 2-aminobenzenesulfonate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2-aminobenzenesulfonate anabolism" EXACT []
synonym: "2-aminobenzenesulfonate biosynthesis" EXACT []
synonym: "2-aminobenzenesulfonate biosynthetic process" EXACT []
synonym: "2-aminobenzenesulfonate formation" EXACT []
synonym: "2-aminobenzenesulfonate synthesis" EXACT []
synonym: "2-aminobenzenesulphonate biosynthesis" EXACT []
synonym: "2-aminobenzenesulphonate biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018868

[Term]
id: GO:0046230
name: 2-aminobenzenesulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai]
synonym: "2-aminobenzenesulfonate breakdown" EXACT []
synonym: "2-aminobenzenesulfonate catabolism" EXACT []
synonym: "2-aminobenzenesulfonate degradation" EXACT []
synonym: "2-aminobenzenesulphonate catabolic process" EXACT []
synonym: "2-aminobenzenesulphonate catabolism" EXACT []
is_a: GO:0009310 ! amine catabolic process
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0046231
name: obsolete carbazole biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai]
comment: This term was made obsolete because carbazole is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "carbazole anabolism" EXACT []
synonym: "carbazole biosynthesis" EXACT []
synonym: "carbazole biosynthetic process" EXACT []
synonym: "carbazole formation" EXACT []
synonym: "carbazole synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018884

[Term]
id: GO:0046232
name: carbazole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai]
synonym: "carbazole breakdown" EXACT []
synonym: "carbazole catabolism" EXACT []
synonym: "carbazole degradation" EXACT []
is_a: GO:0018884 ! carbazole metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046233
name: obsolete 3-hydroxyphenylacetate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [GOC:curator]
comment: This term was made obsolete because 3-hydroxyphenylacetate is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "3-hydroxyphenylacetate anabolism" EXACT []
synonym: "3-hydroxyphenylacetate biosynthesis" EXACT []
synonym: "3-hydroxyphenylacetate biosynthetic process" EXACT []
synonym: "3-hydroxyphenylacetate formation" EXACT []
synonym: "3-hydroxyphenylacetate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019609

[Term]
id: GO:0046234
name: obsolete fluorene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:ai]
comment: This term was made obsolete because fluorene is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "fluorene anabolism" EXACT []
synonym: "fluorene biosynthesis" EXACT []
synonym: "fluorene biosynthetic process" EXACT []
synonym: "fluorene formation" EXACT []
synonym: "fluorene synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0046235
name: obsolete gallate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:ai]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "gallate anabolism" EXACT []
synonym: "gallate biosynthesis" EXACT []
synonym: "gallate formation" EXACT []
synonym: "gallate synthesis" EXACT []
synonym: "gallic acid biosynthesis" EXACT []
synonym: "gallic acid biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0046236
name: mandelate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:ai]
synonym: "mandelate anabolism" EXACT []
synonym: "mandelate biosynthesis" EXACT []
synonym: "mandelate formation" EXACT []
synonym: "mandelate synthesis" EXACT []
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0046237
name: obsolete phenanthrene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because phenanthrene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "phenanthrene anabolism" EXACT []
synonym: "phenanthrene biosynthesis" EXACT []
synonym: "phenanthrene biosynthetic process" EXACT []
synonym: "phenanthrene formation" EXACT []
synonym: "phenanthrene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018955

[Term]
id: GO:0046238
name: obsolete phthalate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid." [GOC:ai]
comment: This term was made obsolete because phthalates are not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "phthalate anabolism" EXACT []
synonym: "phthalate biosynthesis" EXACT []
synonym: "phthalate biosynthetic process" EXACT []
synonym: "phthalate formation" EXACT []
synonym: "phthalate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018963

[Term]
id: GO:0046239
name: phthalate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid." [GOC:ai]
synonym: "phthalate breakdown" EXACT []
synonym: "phthalate catabolism" EXACT []
synonym: "phthalate degradation" EXACT []
is_a: GO:0018963 ! phthalate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0046240
name: obsolete xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:ai]
comment: This term was made obsolete because xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "xylene anabolism" EXACT []
synonym: "xylene biosynthesis" EXACT []
synonym: "xylene biosynthetic process" EXACT []
synonym: "xylene formation" EXACT []
synonym: "xylene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018948

[Term]
id: GO:0046241
name: obsolete m-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because m-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "m-xylene anabolism" EXACT []
synonym: "m-xylene biosynthesis" EXACT []
synonym: "m-xylene biosynthetic process" EXACT []
synonym: "m-xylene formation" EXACT []
synonym: "m-xylene synthesis" EXACT []
synonym: "meta-xylene biosynthesis" EXACT []
synonym: "meta-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018949

[Term]
id: GO:0046242
name: obsolete o-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because o-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "o-xylene anabolism" EXACT []
synonym: "o-xylene biosynthesis" EXACT []
synonym: "o-xylene biosynthetic process" EXACT []
synonym: "o-xylene formation" EXACT []
synonym: "o-xylene synthesis" EXACT []
synonym: "ortho-xylene biosynthesis" EXACT []
synonym: "ortho-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018950

[Term]
id: GO:0046243
name: obsolete p-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because p-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "p-xylene anabolism" EXACT []
synonym: "p-xylene biosynthesis" EXACT []
synonym: "p-xylene biosynthetic process" EXACT []
synonym: "p-xylene formation" EXACT []
synonym: "p-xylene synthesis" EXACT []
synonym: "para-xylene biosynthesis" EXACT []
synonym: "para-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018951

[Term]
id: GO:0046244
name: salicylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [GOC:ai]
synonym: "salicylic acid breakdown" EXACT []
synonym: "salicylic acid catabolism" EXACT []
synonym: "salicylic acid degradation" EXACT []
is_a: GO:0009696 ! salicylic acid metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046245
name: obsolete styrene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:ai]
comment: This term was made obsolete because styrene is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "styrene anabolism" EXACT []
synonym: "styrene biosynthesis" EXACT []
synonym: "styrene biosynthetic process" EXACT []
synonym: "styrene formation" EXACT []
synonym: "styrene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018966

[Term]
id: GO:0046246
name: terpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai]
synonym: "terpene anabolism" EXACT []
synonym: "terpene biosynthesis" EXACT []
synonym: "terpene formation" EXACT []
synonym: "terpene synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0042214 ! terpene metabolic process
is_a: GO:0120251 ! hydrocarbon biosynthetic process

[Term]
id: GO:0046247
name: terpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai]
synonym: "terpene breakdown" EXACT []
synonym: "terpene catabolism" EXACT []
synonym: "terpene degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0042214 ! terpene metabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:0046248
name: alpha-pinene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai]
synonym: "alpha-pinene anabolism" EXACT []
synonym: "alpha-pinene biosynthesis" EXACT []
synonym: "alpha-pinene formation" EXACT []
synonym: "alpha-pinene synthesis" EXACT []
is_a: GO:0018867 ! alpha-pinene metabolic process
is_a: GO:0043693 ! monoterpene biosynthetic process

[Term]
id: GO:0046249
name: alpha-pinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [PMID:10192895, PMID:14736461, PMID:29414896]
synonym: "alpha-pinene breakdown" EXACT []
synonym: "alpha-pinene catabolism" EXACT []
synonym: "alpha-pinene degradation" EXACT []
is_a: GO:0018867 ! alpha-pinene metabolic process
is_a: GO:0033074 ! pinene catabolic process

[Term]
id: GO:0046250
name: limonene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai]
synonym: "limonene anabolism" EXACT []
synonym: "limonene biosynthesis" EXACT []
synonym: "limonene formation" EXACT []
synonym: "limonene synthesis" EXACT []
is_a: GO:0018923 ! limonene metabolic process
is_a: GO:0043693 ! monoterpene biosynthetic process
is_a: GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:0046251
name: limonene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [PMID:10224006]
synonym: "limonene breakdown" EXACT []
synonym: "limonene catabolism" EXACT []
synonym: "limonene degradation" EXACT []
is_a: GO:0018923 ! limonene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0046252
name: toluene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:ai, PMID:6508079]
comment: This term was reinstated from obsolete.
synonym: "toluene anabolism" EXACT []
synonym: "toluene biosynthesis" EXACT []
synonym: "toluene formation" EXACT []
synonym: "toluene synthesis" EXACT []
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0120251 ! hydrocarbon biosynthetic process

[Term]
id: GO:0046253
name: anaerobic toluene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai, PMID:8573493]
comment: This term was reinstated from obsolete.
synonym: "anaerobic toluene anabolism" EXACT []
synonym: "anaerobic toluene biosynthesis" EXACT []
synonym: "anaerobic toluene formation" EXACT []
synonym: "anaerobic toluene synthesis" EXACT []
is_a: GO:0018971 ! anaerobic toluene metabolic process
is_a: GO:0046252 ! toluene biosynthetic process

[Term]
id: GO:0046254
name: anaerobic toluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai]
synonym: "anaerobic toluene breakdown" EXACT []
synonym: "anaerobic toluene catabolism" EXACT []
synonym: "anaerobic toluene degradation" EXACT []
xref: MetaCyc:PWY-81
is_a: GO:0042203 ! toluene catabolic process

[Term]
id: GO:0046255
name: obsolete 2,4,6-trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2,4,6-trinitrotoluene anabolism" EXACT []
synonym: "2,4,6-trinitrotoluene biosynthesis" EXACT []
synonym: "2,4,6-trinitrotoluene biosynthetic process" EXACT []
synonym: "2,4,6-trinitrotoluene formation" EXACT []
synonym: "2,4,6-trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018974

[Term]
id: GO:0046256
name: 2,4,6-trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid." [GOC:ai]
synonym: "2,4,6-trinitrotoluene breakdown" EXACT []
synonym: "2,4,6-trinitrotoluene catabolism" EXACT []
synonym: "2,4,6-trinitrotoluene degradation" EXACT []
is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process
is_a: GO:0046260 ! trinitrotoluene catabolic process

[Term]
id: GO:0046257
name: obsolete anaerobic 2,4,6-trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai]
comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "anaerobic 2,4,6-trinitrotoluene anabolism" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene biosynthesis" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene biosynthetic process" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene formation" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018975

[Term]
id: GO:0046258
name: anaerobic 2,4,6-trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai]
synonym: "anaerobic 2,4,6-trinitrotoluene breakdown" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene catabolism" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene degradation" EXACT []
is_a: GO:0018975 ! anaerobic 2,4,6-trinitrotoluene metabolic process
is_a: GO:0046256 ! 2,4,6-trinitrotoluene catabolic process

[Term]
id: GO:0046259
name: obsolete trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it." [GOC:ai]
comment: This term was made obsolete because trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "trinitrotoluene anabolism" EXACT []
synonym: "trinitrotoluene biosynthesis" EXACT []
synonym: "trinitrotoluene biosynthetic process" EXACT []
synonym: "trinitrotoluene formation" EXACT []
synonym: "trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018973

[Term]
id: GO:0046260
name: trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
synonym: "trinitrotoluene breakdown" EXACT []
synonym: "trinitrotoluene catabolism" EXACT []
synonym: "trinitrotoluene degradation" EXACT []
is_a: GO:0018973 ! trinitrotoluene metabolic process
is_a: GO:0046263 ! nitrotoluene catabolic process

[Term]
id: GO:0046261
name: obsolete 4-nitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai]
comment: This term was made obsolete because 4-nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-nitrotoluene anabolism" EXACT []
synonym: "4-nitrotoluene biosynthesis" EXACT []
synonym: "4-nitrotoluene biosynthetic process" EXACT []
synonym: "4-nitrotoluene formation" EXACT []
synonym: "4-nitrotoluene synthesis" EXACT []
synonym: "4NT biosynthesis" EXACT []
synonym: "4NT biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0019257

[Term]
id: GO:0046262
name: obsolete nitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
comment: This term was made obsolete because nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "nitrotoluene anabolism" EXACT []
synonym: "nitrotoluene biosynthesis" EXACT []
synonym: "nitrotoluene biosynthetic process" EXACT []
synonym: "nitrotoluene formation" EXACT []
synonym: "nitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019326

[Term]
id: GO:0046263
name: nitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
synonym: "nitrotoluene breakdown" EXACT []
synonym: "nitrotoluene catabolism" EXACT []
synonym: "nitrotoluene degradation" EXACT []
is_a: GO:0019326 ! nitrotoluene metabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0046264
name: obsolete thiocyanate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid." [GOC:ai]
comment: This term was made obsolete because thiocyanates are not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "thiocyanate anabolism" EXACT []
synonym: "thiocyanate biosynthesis" EXACT []
synonym: "thiocyanate biosynthetic process" EXACT []
synonym: "thiocyanate formation" EXACT []
synonym: "thiocyanate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018969

[Term]
id: GO:0046265
name: thiocyanate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid." [GOC:ai]
synonym: "thiocyanate breakdown" EXACT []
synonym: "thiocyanate catabolism" EXACT []
synonym: "thiocyanate degradation" EXACT []
is_a: GO:0018969 ! thiocyanate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0046266
name: obsolete triethanolamine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai]
comment: This term was made obsolete because triethanolamine is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "triethanolamine anabolism" EXACT []
synonym: "triethanolamine biosynthesis" EXACT []
synonym: "triethanolamine biosynthetic process" EXACT []
synonym: "triethanolamine formation" EXACT []
synonym: "triethanolamine synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0046267
name: obsolete triethanolamine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai]
comment: Triethanolamine is not a natural compound.
synonym: "triethanolamine breakdown" EXACT []
synonym: "triethanolamine catabolism" EXACT []
synonym: "triethanolamine degradation" EXACT []
is_obsolete: true
consider: GO:0042178

[Term]
id: GO:0046268
name: obsolete toluene-4-sulfonate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai]
comment: This term was made obsolete because toluene-4-sulfonate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-toluenesulfonate biosynthesis" EXACT []
synonym: "4-toluenesulfonate biosynthetic process" EXACT []
synonym: "toluene-4-sulfonate anabolism" EXACT []
synonym: "toluene-4-sulfonate biosynthesis" EXACT []
synonym: "toluene-4-sulfonate biosynthetic process" EXACT []
synonym: "toluene-4-sulfonate formation" EXACT []
synonym: "toluene-4-sulfonate synthesis" EXACT []
synonym: "toluene-4-sulphonate biosynthesis" EXACT []
synonym: "toluene-4-sulphonate biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018972

[Term]
id: GO:0046269
name: toluene-4-sulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai]
synonym: "4-toluenesulfonate catabolic process" EXACT []
synonym: "4-toluenesulfonate catabolism" EXACT []
synonym: "toluene-4-sulfonate breakdown" EXACT []
synonym: "toluene-4-sulfonate catabolism" EXACT []
synonym: "toluene-4-sulfonate degradation" EXACT []
synonym: "toluene-4-sulphonate catabolic process" EXACT []
synonym: "toluene-4-sulphonate catabolism" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0018972 ! toluene-4-sulfonate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0046270
name: obsolete 4-toluenecarboxylate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
comment: This term was made obsolete because 4-toluenecarboxylate is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "4-toluenecarboxylate anabolism" EXACT []
synonym: "4-toluenecarboxylate biosynthesis" EXACT []
synonym: "4-toluenecarboxylate biosynthetic process" EXACT []
synonym: "4-toluenecarboxylate formation" EXACT []
synonym: "4-toluenecarboxylate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019611

[Term]
id: GO:0046271
name: phenylpropanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid." [GOC:ai]
synonym: "phenylpropanoid breakdown" EXACT []
synonym: "phenylpropanoid catabolism" EXACT []
synonym: "phenylpropanoid degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0046272
name: stilbene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:ai]
synonym: "stilbene breakdown" EXACT []
synonym: "stilbene catabolism" EXACT []
synonym: "stilbene degradation" EXACT []
is_a: GO:0009810 ! stilbene metabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0046273
name: lignan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
synonym: "lignan breakdown" EXACT []
synonym: "lignan catabolism" EXACT []
synonym: "lignan degradation" EXACT []
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046274
name: lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units." [GOC:ai]
synonym: "lignin breakdown" EXACT []
synonym: "lignin catabolism" EXACT []
synonym: "lignin degradation" EXACT []
is_a: GO:0009808 ! lignin metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046275
name: flavonoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:ai]
synonym: "flavonoid breakdown" EXACT []
synonym: "flavonoid catabolism" EXACT []
synonym: "flavonoid degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0046276
name: methylgallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
synonym: "methylgallate breakdown" EXACT []
synonym: "methylgallate catabolism" EXACT []
synonym: "methylgallate degradation" EXACT []
xref: MetaCyc:METHYLGALLATE-DEGRADATION-PWY
is_a: GO:0019489 ! methylgallate metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046277
name: methylgallate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
synonym: "methylgallate anabolism" EXACT []
synonym: "methylgallate biosynthesis" EXACT []
synonym: "methylgallate formation" EXACT []
synonym: "methylgallate synthesis" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0019489 ! methylgallate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046278
name: 3,4-dihydroxybenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid)." [GOC:ai, PMID:24359411]
synonym: "protocatechuate metabolic process" EXACT [PMID:25072253]
synonym: "protocatechuate metabolism" EXACT []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0046279
name: 3,4-dihydroxybenzoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate." [GOC:ai]
synonym: "protocatechuate anabolism" EXACT []
synonym: "protocatechuate biosynthesis" EXACT []
synonym: "protocatechuate biosynthetic process" EXACT [PMID:25072253]
synonym: "protocatechuate formation" EXACT []
synonym: "protocatechuate synthesis" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046280
name: chalcone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:ai]
synonym: "chalcone breakdown" EXACT []
synonym: "chalcone catabolism" EXACT []
synonym: "chalcone degradation" EXACT []
is_a: GO:0009714 ! chalcone metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0046281
name: cinnamic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:ai]
synonym: "cinnamic acid breakdown" EXACT []
synonym: "cinnamic acid catabolism" EXACT []
synonym: "cinnamic acid degradation" EXACT []
synonym: "cinnamylic acid catabolic process" EXACT []
synonym: "cinnamylic acid catabolism" EXACT []
synonym: "phenylacrylic acid catabolic process" EXACT []
synonym: "phenylacrylic acid catabolism" EXACT []
is_a: GO:0009803 ! cinnamic acid metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0046282
name: cinnamic acid ester catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:ai]
synonym: "cinnamic acid ester breakdown" EXACT []
synonym: "cinnamic acid ester catabolism" EXACT []
synonym: "cinnamic acid ester degradation" EXACT []
is_a: GO:0009801 ! cinnamic acid ester metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0046283
name: anthocyanin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers." [ISBN:0198506732]
synonym: "anthocyanin metabolic process" EXACT []
synonym: "anthocyanin metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0046284
name: anthocyanin-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai]
synonym: "anthocyanin breakdown" EXACT []
synonym: "anthocyanin catabolic process" EXACT []
synonym: "anthocyanin catabolism" EXACT []
synonym: "anthocyanin degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046149 ! pigment catabolic process
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0046285
name: flavonoid phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732]
synonym: "flavonoid phytoalexin metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0046286
name: flavonoid phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
synonym: "flavonoid phytoalexin breakdown" EXACT []
synonym: "flavonoid phytoalexin catabolism" EXACT []
synonym: "flavonoid phytoalexin degradation" EXACT []
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:0046285 ! flavonoid phytoalexin metabolic process
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046287
name: isoflavonoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group." [GOC:ai, PMID:15734910]
synonym: "isoflavonoid metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0046288
name: isoflavonoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai]
synonym: "isoflavonoid breakdown" EXACT []
synonym: "isoflavonoid catabolism" EXACT []
synonym: "isoflavonoid degradation" EXACT []
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0046287 ! isoflavonoid metabolic process

[Term]
id: GO:0046289
name: isoflavonoid phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
synonym: "isoflavonoid phytoalexin metabolism" EXACT []
is_a: GO:0046287 ! isoflavonoid metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0046290
name: isoflavonoid phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
synonym: "isoflavonoid phytoalexin breakdown" EXACT []
synonym: "isoflavonoid phytoalexin catabolism" EXACT []
synonym: "isoflavonoid phytoalexin degradation" EXACT []
is_a: GO:0046288 ! isoflavonoid catabolic process
is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046291
name: obsolete 6-hydroxycineole biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
comment: This term was made obsolete because 6-hydroxycineole is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "6-endo-hydroxycineole biosynthesis" EXACT []
synonym: "6-endo-hydroxycineole biosynthetic process" EXACT []
synonym: "6-hydroxycineole anabolism" EXACT []
synonym: "6-hydroxycineole biosynthesis" EXACT []
synonym: "6-hydroxycineole biosynthetic process" EXACT []
synonym: "6-hydroxycineole formation" EXACT []
synonym: "6-hydroxycineole synthesis" EXACT []
synonym: "hydroxycineol biosynthesis" EXACT []
synonym: "hydroxycineol biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0019638

[Term]
id: GO:0046292
name: formaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent." [GOC:ai]
synonym: "formaldehyde metabolism" EXACT []
synonym: "methanal metabolic process" EXACT []
synonym: "methanal metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0046293
name: formaldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
synonym: "formaldehyde anabolism" EXACT []
synonym: "formaldehyde biosynthesis" EXACT []
synonym: "formaldehyde formation" EXACT []
synonym: "formaldehyde synthesis" EXACT []
synonym: "methanal biosynthesis" EXACT []
synonym: "methanal biosynthetic process" EXACT []
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0046294
name: formaldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
synonym: "formaldehyde breakdown" EXACT []
synonym: "formaldehyde catabolism" EXACT []
synonym: "formaldehyde degradation" EXACT []
synonym: "methanal catabolic process" EXACT []
synonym: "methanal catabolism" EXACT []
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046292 ! formaldehyde metabolic process
is_a: GO:0110095 ! cellular detoxification of aldehyde

[Term]
id: GO:0046295
name: glycolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai]
synonym: "glycolate anabolism" EXACT []
synonym: "glycolate biosynthesis" EXACT []
synonym: "glycolate formation" EXACT []
synonym: "glycolate synthesis" EXACT []
is_a: GO:0009441 ! glycolate metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046296
name: glycolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai]
synonym: "glycolate breakdown" EXACT []
synonym: "glycolate catabolism" EXACT []
synonym: "glycolate degradation" EXACT []
is_a: GO:0009441 ! glycolate metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046297
name: obsolete 2,4-dichlorobenzoate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai]
comment: This term was made obsolete because 2,4-dichlorobenzoate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2,4-dichlorobenzoate anabolism" EXACT []
synonym: "2,4-dichlorobenzoate biosynthesis" EXACT []
synonym: "2,4-dichlorobenzoate biosynthetic process" EXACT []
synonym: "2,4-dichlorobenzoate formation" EXACT []
synonym: "2,4-dichlorobenzoate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018898

[Term]
id: GO:0046298
name: 2,4-dichlorobenzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai]
synonym: "2,4-dichlorobenzoate breakdown" EXACT []
synonym: "2,4-dichlorobenzoate catabolism" EXACT []
synonym: "2,4-dichlorobenzoate degradation" EXACT []
is_a: GO:0018898 ! 2,4-dichlorobenzoate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046299
name: obsolete 2,4-dichlorophenoxyacetic acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai]
comment: This term was made obsolete because 2,4-dichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2,4-dichlorophenoxyacetic acid anabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid biosynthesis" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid biosynthetic process" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid formation" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018901

[Term]
id: GO:0046300
name: 2,4-dichlorophenoxyacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai, UM-BBD_pathwayID:2\,4-d]
synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT []
xref: UM-BBD_pathwayID:2\,4-d
is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0046301
name: obsolete 2-chloro-N-isopropylacetanilide biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai]
comment: This term was made obsolete because 2-chloro-N-isopropylacetanilide is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2-chloro-N-isopropylacetanilide anabolism" EXACT []
synonym: "2-chloro-N-isopropylacetanilide biosynthesis" EXACT []
synonym: "2-chloro-N-isopropylacetanilide biosynthetic process" EXACT []
synonym: "2-chloro-N-isopropylacetanilide formation" EXACT []
synonym: "2-chloro-N-isopropylacetanilide synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018889

[Term]
id: GO:0046302
name: 2-chloro-N-isopropylacetanilide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai]
synonym: "2-chloro-N-isopropylacetanilide breakdown" EXACT []
synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT []
synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process

[Term]
id: GO:0046303
name: obsolete 2-nitropropane biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai]
comment: This term was made obsolete because 2-nitropropane is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2-nitropropane anabolism" EXACT []
synonym: "2-nitropropane biosynthesis" EXACT []
synonym: "2-nitropropane biosynthetic process" EXACT []
synonym: "2-nitropropane formation" EXACT []
synonym: "2-nitropropane synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018938

[Term]
id: GO:0046304
name: 2-nitropropane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai]
synonym: "2-nitropropane breakdown" EXACT []
synonym: "2-nitropropane catabolism" EXACT []
synonym: "2-nitropropane degradation" EXACT []
is_a: GO:0018938 ! 2-nitropropane metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046305
name: alkanesulfonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai]
synonym: "alkanesulfonate anabolism" EXACT []
synonym: "alkanesulfonate biosynthesis" EXACT []
synonym: "alkanesulfonate formation" EXACT []
synonym: "alkanesulfonate synthesis" EXACT []
synonym: "alkanesulphonate biosynthesis" EXACT []
synonym: "alkanesulphonate biosynthetic process" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0046306
name: alkanesulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai]
synonym: "alkanesulfonate breakdown" EXACT []
synonym: "alkanesulfonate catabolism" EXACT []
synonym: "alkanesulfonate degradation" EXACT []
synonym: "alkanesulphonate catabolic process" EXACT []
synonym: "alkanesulphonate catabolism" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0046307
name: Z-phenylacetaldoxime biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai]
synonym: "Z-phenylacetaldoxime anabolism" EXACT []
synonym: "Z-phenylacetaldoxime biosynthesis" EXACT []
synonym: "Z-phenylacetaldoxime formation" EXACT []
synonym: "Z-phenylacetaldoxime synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process

[Term]
id: GO:0046308
name: Z-phenylacetaldoxime catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai]
synonym: "Z-phenylacetaldoxime breakdown" EXACT []
synonym: "Z-phenylacetaldoxime catabolism" EXACT []
synonym: "Z-phenylacetaldoxime degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process

[Term]
id: GO:0046309
name: obsolete 1,3-dichloro-2-propanol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai]
comment: 1,3-dichloro-2-propanol is not a natural compound.
synonym: "1,3-dichloro-2-propanol anabolism" EXACT []
synonym: "1,3-dichloro-2-propanol biosynthesis" EXACT []
synonym: "1,3-dichloro-2-propanol formation" EXACT []
synonym: "1,3-dichloro-2-propanol synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0046310
name: obsolete 1,3-dichloro-2-propanol catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai]
comment: 1,3-dichloro-2-propanol is not a natural compound.
synonym: "1,3-dichloro-2-propanol breakdown" EXACT []
synonym: "1,3-dichloro-2-propanol catabolism" EXACT []
synonym: "1,3-dichloro-2-propanol degradation" EXACT []
is_obsolete: true
consider: GO:0042178

[Term]
id: GO:0046311
name: prenylcysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]
synonym: "prenylcysteine anabolism" EXACT []
synonym: "prenylcysteine biosynthesis" EXACT []
synonym: "prenylcysteine formation" EXACT []
synonym: "prenylcysteine synthesis" EXACT []
is_a: GO:0030329 ! prenylcysteine metabolic process
is_a: GO:0042398 ! modified amino acid biosynthetic process

[Term]
id: GO:0046312
name: phosphoarginine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai]
synonym: "phosphoarginine anabolism" EXACT []
synonym: "phosphoarginine biosynthesis" EXACT []
synonym: "phosphoarginine formation" EXACT []
synonym: "phosphoarginine synthesis" EXACT []
is_a: GO:0006604 ! phosphoarginine metabolic process
is_a: GO:0042396 ! phosphagen biosynthetic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0046313
name: phosphoarginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai]
synonym: "phosphoarginine breakdown" EXACT []
synonym: "phosphoarginine catabolism" EXACT []
synonym: "phosphoarginine degradation" EXACT []
is_a: GO:0006604 ! phosphoarginine metabolic process
is_a: GO:0042397 ! phosphagen catabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0046314
name: phosphocreatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]
synonym: "phosphocreatine anabolism" EXACT []
synonym: "phosphocreatine biosynthesis" EXACT []
synonym: "phosphocreatine formation" EXACT []
synonym: "phosphocreatine synthesis" EXACT []
is_a: GO:0006603 ! phosphocreatine metabolic process
is_a: GO:0042396 ! phosphagen biosynthetic process

[Term]
id: GO:0046315
name: phosphocreatine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]
synonym: "phosphocreatine breakdown" EXACT []
synonym: "phosphocreatine catabolism" EXACT []
synonym: "phosphocreatine degradation" EXACT []
is_a: GO:0006603 ! phosphocreatine metabolic process
is_a: GO:0042397 ! phosphagen catabolic process

[Term]
id: GO:0046316
name: gluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+." [EC:2.7.1.12, RHEA:19433]
synonym: "ATP:D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.12]
synonym: "gluconate kinase activity" RELATED [EC:2.7.1.12]
synonym: "gluconokinase (phosphorylating)" RELATED [EC:2.7.1.12]
xref: EC:2.7.1.12
xref: KEGG_REACTION:R01737
xref: MetaCyc:GLUCONOKIN-RXN
xref: RHEA:19433
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0046317
name: regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of glucosylceramide anabolism" EXACT []
synonym: "regulation of glucosylceramide biosynthesis" EXACT []
synonym: "regulation of glucosylceramide formation" EXACT []
synonym: "regulation of glucosylceramide synthesis" EXACT []
is_a: GO:2000303 ! regulation of ceramide biosynthetic process
relationship: regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046318
name: negative regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "down regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "down-regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "downregulation of glucosylceramide biosynthetic process" EXACT []
synonym: "inhibition of glucosylceramide biosynthetic process" NARROW []
synonym: "negative regulation of glucosylceramide anabolism" EXACT []
synonym: "negative regulation of glucosylceramide biosynthesis" EXACT []
synonym: "negative regulation of glucosylceramide formation" EXACT []
synonym: "negative regulation of glucosylceramide synthesis" EXACT []
is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process
is_a: GO:1900060 ! negative regulation of ceramide biosynthetic process
relationship: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046319
name: positive regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai]
synonym: "activation of glucosylceramide biosynthetic process" NARROW []
synonym: "positive regulation of glucosylceramide anabolism" EXACT []
synonym: "positive regulation of glucosylceramide biosynthesis" EXACT []
synonym: "positive regulation of glucosylceramide formation" EXACT []
synonym: "positive regulation of glucosylceramide synthesis" EXACT []
synonym: "stimulation of glucosylceramide biosynthetic process" NARROW []
synonym: "up regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "up-regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "upregulation of glucosylceramide biosynthetic process" EXACT []
is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process
is_a: GO:2000304 ! positive regulation of ceramide biosynthetic process
relationship: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046320
name: regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
relationship: regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046321
name: positive regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
synonym: "activation of fatty acid oxidation" NARROW []
synonym: "stimulation of fatty acid oxidation" NARROW []
synonym: "up regulation of fatty acid oxidation" EXACT []
synonym: "up-regulation of fatty acid oxidation" EXACT []
synonym: "upregulation of fatty acid oxidation" EXACT []
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
relationship: positively_regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046322
name: negative regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
synonym: "down regulation of fatty acid oxidation" EXACT []
synonym: "down-regulation of fatty acid oxidation" EXACT []
synonym: "downregulation of fatty acid oxidation" EXACT []
synonym: "inhibition of fatty acid oxidation" NARROW []
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
relationship: negatively_regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046323
name: D-glucose import
namespace: biological_process
def: "The directed movement of the hexose monosaccharide D-glucose into a cell or organelle." [GOC:ai]
synonym: "glucose import" EXACT []
synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Glucose_uptake
is_a: GO:1904659 ! D-glucose transmembrane transport

[Term]
id: GO:0046324
name: regulation of D-glucose import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
synonym: "regulation of glucose import" EXACT []
synonym: "regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010827 ! regulation of D-glucose transmembrane transport
relationship: regulates GO:0046323 ! D-glucose import

[Term]
id: GO:0046325
name: negative regulation of D-glucose import
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
synonym: "down regulation of glucose import" EXACT []
synonym: "down-regulation of glucose import" EXACT []
synonym: "downregulation of glucose import" EXACT []
synonym: "inhibition of glucose import" NARROW []
synonym: "negative regulation of glucose import" EXACT []
synonym: "negative regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010829 ! negative regulation of D-glucose transmembrane transport
is_a: GO:0046324 ! regulation of D-glucose import
relationship: negatively_regulates GO:0046323 ! D-glucose import

[Term]
id: GO:0046326
name: positive regulation of D-glucose import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of glucose import" NARROW []
synonym: "positive regulation of glucose import" EXACT []
synonym: "positive regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of glucose import" NARROW []
synonym: "up regulation of glucose import" EXACT []
synonym: "up-regulation of glucose import" EXACT []
synonym: "upregulation of glucose import" EXACT []
is_a: GO:0010828 ! positive regulation of D-glucose transmembrane transport
is_a: GO:0046324 ! regulation of D-glucose import
relationship: positively_regulates GO:0046323 ! D-glucose import

[Term]
id: GO:0046327
name: glycerol biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate." [GOC:ai]
synonym: "glycerol anabolism from pyruvate" EXACT []
synonym: "glycerol formation from pyruvate" EXACT []
synonym: "glycerol synthesis from pyruvate" EXACT []
synonym: "glyceroneogenesis" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006114 ! glycerol biosynthetic process
relationship: part_of GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0046328
name: regulation of JNK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "regulation of SAPK cascade" BROAD []
is_a: GO:0043408 ! regulation of MAPK cascade
relationship: regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046329
name: negative regulation of JNK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "down regulation of JNK cascade" EXACT []
synonym: "down-regulation of JNK cascade" EXACT []
synonym: "downregulation of JNK cascade" EXACT []
synonym: "inhibition of JNK cascade" NARROW []
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0046328 ! regulation of JNK cascade
relationship: negatively_regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046330
name: positive regulation of JNK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "activation of JNK cascade" NARROW []
synonym: "stimulation of JNK cascade" NARROW []
synonym: "up regulation of JNK cascade" EXACT []
synonym: "up-regulation of JNK cascade" EXACT []
synonym: "upregulation of JNK cascade" EXACT []
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0046328 ! regulation of JNK cascade
relationship: positively_regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046331
name: lateral inhibition
namespace: biological_process
def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment

[Term]
id: GO:0046332
name: SMAD binding
namespace: molecular_function
def: "Binding to a SMAD signaling protein." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046333
name: octopamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
synonym: "octopamine metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process

[Term]
id: GO:0046334
name: octopamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
synonym: "octopamine breakdown" EXACT []
synonym: "octopamine catabolism" EXACT []
synonym: "octopamine degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042402 ! biogenic amine catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046333 ! octopamine metabolic process

[Term]
id: GO:0046335
name: ethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai]
synonym: "ethanolamine anabolism" EXACT []
synonym: "ethanolamine biosynthesis" EXACT []
synonym: "ethanolamine formation" EXACT []
synonym: "ethanolamine synthesis" EXACT []
is_a: GO:0006580 ! ethanolamine metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042401 ! biogenic amine biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0046336
name: ethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai]
synonym: "ethanolamine breakdown" EXACT []
synonym: "ethanolamine catabolism" EXACT []
synonym: "ethanolamine degradation" EXACT []
is_a: GO:0006580 ! ethanolamine metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0042402 ! biogenic amine catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0046337
name: phosphatidylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]
synonym: "phosphatidylethanolamine metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046338
name: phosphatidylethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
synonym: "phosphatidylethanolamine breakdown" EXACT []
synonym: "phosphatidylethanolamine catabolism" EXACT []
synonym: "phosphatidylethanolamine degradation" EXACT []
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0046339
name: diacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11481335]
synonym: "diacylglycerol metabolism" EXACT []
synonym: "diglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0046340
name: diacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312]
synonym: "diacylglycerol breakdown" EXACT []
synonym: "diacylglycerol catabolism" EXACT []
synonym: "diacylglycerol degradation" EXACT []
synonym: "diglyceride catabolism" EXACT []
is_a: GO:0046339 ! diacylglycerol metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process

[Term]
id: GO:0046341
name: CDP-diacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [PMID:24533860]
synonym: "CDP-diacylglycerol metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046342
name: CDP-diacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [PMID:6147353]
synonym: "CDP-diacylglycerol breakdown" EXACT []
synonym: "CDP-diacylglycerol catabolism" EXACT []
synonym: "CDP-diacylglycerol degradation" EXACT []
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0046343
name: streptomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [PMID:2111804]
synonym: "streptomycin metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:0046344
name: ecdysteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai]
synonym: "ecdysteroid breakdown" EXACT []
synonym: "ecdysteroid catabolism" EXACT []
synonym: "ecdysteroid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0046345
name: abscisic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [GOC:ai]
synonym: "abscisic acid breakdown" EXACT []
synonym: "abscisic acid catabolism" EXACT []
synonym: "abscisic acid degradation" EXACT []
is_a: GO:0009687 ! abscisic acid metabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0043290 ! apocarotenoid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process

[Term]
id: GO:0046346
name: mannosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators]
synonym: "mannosamine breakdown" EXACT []
synonym: "mannosamine catabolism" EXACT []
synonym: "mannosamine degradation" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0046347
name: mannosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators]
synonym: "mannosamine anabolism" EXACT []
synonym: "mannosamine biosynthesis" EXACT []
synonym: "mannosamine formation" EXACT []
synonym: "mannosamine synthesis" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0046348
name: amino sugar catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators]
synonym: "amino sugar breakdown" EXACT []
synonym: "amino sugar catabolism" EXACT []
synonym: "amino sugar degradation" EXACT []
synonym: "aminosaccharide catabolic process" EXACT []
synonym: "aminosaccharide catabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0046349
name: amino sugar biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators]
synonym: "amino sugar anabolism" EXACT []
synonym: "amino sugar biosynthesis" EXACT []
synonym: "amino sugar formation" EXACT []
synonym: "amino sugar synthesis" EXACT []
synonym: "aminosaccharide biosynthesis" EXACT []
synonym: "aminosaccharide biosynthetic process" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046350
name: obsolete galactosaminoglycan metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
comment: This term was obsoleted because it was too broad.
synonym: "galactosaminoglycan metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0046351
name: disaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai]
synonym: "disaccharide anabolism" EXACT []
synonym: "disaccharide biosynthesis" EXACT []
synonym: "disaccharide formation" EXACT []
synonym: "disaccharide synthesis" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0009312 ! oligosaccharide biosynthetic process

[Term]
id: GO:0046352
name: disaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units." [GOC:ai]
synonym: "disaccharide breakdown" EXACT []
synonym: "disaccharide catabolism" EXACT []
synonym: "disaccharide degradation" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0009313 ! oligosaccharide catabolic process

[Term]
id: GO:0046353
name: aminoglycoside 3-N-acetyltransferase activity
namespace: molecular_function
alt_id: GO:0016991
def: "Catalysis of the reaction: a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H+." [RHEA:12665]
synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81]
synonym: "3-N-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81]
synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" RELATED [EC:2.3.1.81]
synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60]
synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60]
synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60]
synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW []
synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60]
synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81]
synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT []
synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60]
xref: EC:2.3.1.81
xref: MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN
xref: RHEA:12665
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0046354
name: mannan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732]
synonym: "mannan anabolism" EXACT []
synonym: "mannan biosynthesis" EXACT []
synonym: "mannan formation" EXACT []
synonym: "mannan synthesis" EXACT []
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0046355
name: mannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732]
synonym: "mannan breakdown" EXACT []
synonym: "mannan catabolism" EXACT []
synonym: "mannan degradation" EXACT []
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0044347 ! cell wall polysaccharide catabolic process

[Term]
id: GO:0046356
name: acetyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:ai]
synonym: "acetyl-CoA breakdown" EXACT []
synonym: "acetyl-CoA catabolism" EXACT []
synonym: "acetyl-CoA degradation" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0046357
name: galactarate biosynthetic process
namespace: biological_process
alt_id: GO:0042872
def: "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid." [GOC:pr, ISBN:0198506732]
synonym: "D-galactarate anabolism" RELATED []
synonym: "D-galactarate biosynthesis" RELATED []
synonym: "D-galactarate biosynthetic process" RELATED []
synonym: "D-galactarate formation" RELATED []
synonym: "D-galactarate synthesis" RELATED []
synonym: "galactarate anabolism" EXACT []
synonym: "galactarate biosynthesis" EXACT []
synonym: "galactarate formation" EXACT []
synonym: "galactarate synthesis" EXACT []
is_a: GO:0019578 ! aldaric acid biosynthetic process
is_a: GO:0019580 ! galactarate metabolic process

[Term]
id: GO:0046358
name: butyrate biosynthetic process
namespace: biological_process
alt_id: GO:0043439
def: "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid." [ISBN:0198506732]
synonym: "butanoic acid anabolism" EXACT []
synonym: "butanoic acid biosynthesis" EXACT []
synonym: "butanoic acid biosynthetic process" EXACT []
synonym: "butanoic acid formation" EXACT []
synonym: "butanoic acid synthesis" EXACT []
synonym: "butyrate anabolism" EXACT []
synonym: "butyrate biosynthesis" EXACT []
synonym: "butyrate formation" EXACT []
synonym: "butyrate synthesis" EXACT []
is_a: GO:0019605 ! butyrate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0046359
name: butyrate catabolic process
namespace: biological_process
alt_id: GO:0043440
def: "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732]
synonym: "butanoic acid breakdown" EXACT []
synonym: "butanoic acid catabolic process" EXACT []
synonym: "butanoic acid catabolism" EXACT []
synonym: "butanoic acid degradation" EXACT []
synonym: "butyrate breakdown" EXACT []
synonym: "butyrate catabolism" EXACT []
synonym: "butyrate degradation" EXACT []
is_a: GO:0019605 ! butyrate metabolic process
is_a: GO:0019626 ! short-chain fatty acid catabolic process

[Term]
id: GO:0046360
name: 2-oxobutyrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732]
synonym: "2-oxobutyrate anabolism" EXACT []
synonym: "2-oxobutyrate biosynthesis" EXACT []
synonym: "2-oxobutyrate formation" EXACT []
synonym: "2-oxobutyrate synthesis" EXACT []
synonym: "alpha-ketobutyrate biosynthesis" EXACT []
synonym: "alpha-ketobutyrate biosynthetic process" EXACT []
is_a: GO:0046361 ! 2-oxobutyrate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0046361
name: 2-oxobutyrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [PMID:17034760]
synonym: "2-oxobutyrate metabolism" EXACT []
synonym: "alpha-ketobutyrate metabolic process" EXACT []
synonym: "alpha-ketobutyrate metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0046362
name: ribitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732]
synonym: "ribitol anabolism" EXACT []
synonym: "ribitol biosynthesis" EXACT []
synonym: "ribitol formation" EXACT []
synonym: "ribitol synthesis" EXACT []
is_a: GO:0019349 ! ribitol metabolic process
is_a: GO:0019526 ! pentitol biosynthetic process

[Term]
id: GO:0046363
name: ribitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732]
synonym: "ribitol breakdown" EXACT []
synonym: "ribitol catabolism" EXACT []
synonym: "ribitol degradation" EXACT []
is_a: GO:0019349 ! ribitol metabolic process
is_a: GO:0019527 ! pentitol catabolic process

[Term]
id: GO:0046364
name: monosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732]
synonym: "monosaccharide anabolism" EXACT []
synonym: "monosaccharide biosynthesis" EXACT []
synonym: "monosaccharide formation" EXACT []
synonym: "monosaccharide synthesis" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0046365
name: monosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732]
synonym: "monosaccharide breakdown" EXACT []
synonym: "monosaccharide catabolism" EXACT []
synonym: "monosaccharide degradation" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0046366
name: obsolete allose biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732]
comment: The reason for obsoletion is that this term is practically equivalent to D-allose biosynthetic process.
synonym: "allose anabolism" EXACT []
synonym: "allose biosynthesis" EXACT []
synonym: "allose formation" EXACT []
synonym: "allose synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019315

[Term]
id: GO:0046367
name: obsolete allose catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732]
comment: The reason for obsoletion is that this term is practically equivalent to D-allose catabolic process.
synonym: "allose breakdown" EXACT []
synonym: "allose catabolism" EXACT []
synonym: "allose degradation" EXACT []
is_obsolete: true
replaced_by: GO:0019316

[Term]
id: GO:0046368
name: GDP-L-fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-L-fucose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046369
name: galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose." [ISBN:0198506732]
synonym: "galactose anabolism" EXACT []
synonym: "galactose biosynthesis" EXACT []
synonym: "galactose formation" EXACT []
synonym: "galactose synthesis" EXACT []
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046370
name: fructose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose." [GOC:ai]
synonym: "fructose anabolism" EXACT []
synonym: "fructose biosynthesis" EXACT []
synonym: "fructose formation" EXACT []
synonym: "fructose synthesis" EXACT []
is_a: GO:0006000 ! fructose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046371
name: dTDP-mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
synonym: "dTDP-mannose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046372
name: D-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "D-arabinose metabolism" EXACT []
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0046373
name: L-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "L-arabinose metabolism" EXACT []
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0046374
name: teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732]
synonym: "teichoic acid metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046375
name: K antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732]
synonym: "K antigen metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046376
name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [ISBN:0198506732]
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0046377
name: colanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues." [GOC:ai, PMID:35630322]
synonym: "colanic acid metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046378
name: enterobacterial common antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma]
synonym: "enterobacterial common antigen metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046379
name: obsolete extracellular polysaccharide metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai]
comment: The reason for obsoletion is that this term is redundant with GO:0005976, polysaccharide metabolic process
synonym: "extracellular polysaccharide metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0005976

[Term]
id: GO:0046380
name: N-acetylneuraminate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]
synonym: "N-acetylneuraminate anabolism" EXACT []
synonym: "N-acetylneuraminate biosynthesis" EXACT []
synonym: "N-acetylneuraminate formation" EXACT []
synonym: "N-acetylneuraminate synthesis" EXACT []
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0046381
name: CMP-N-acetylneuraminate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai]
synonym: "CMP-N-acetylneuraminate metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046382
name: GDP-D-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-D-rhamnose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046383
name: dTDP-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
synonym: "dTDP-rhamnose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046384
name: 2-deoxyribose 1-phosphate metabolic process
namespace: biological_process
alt_id: GO:0046388
def: "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732]
synonym: "2-deoxyribose 1-phosphate metabolism" EXACT []
synonym: "deoxyribose 1-phosphate metabolic process" EXACT []
synonym: "deoxyribose 1-phosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046385
name: deoxyribose phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732]
synonym: "deoxyribose phosphate anabolism" EXACT []
synonym: "deoxyribose phosphate biosynthesis" EXACT []
synonym: "deoxyribose phosphate formation" EXACT []
synonym: "deoxyribose phosphate synthesis" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046386
name: deoxyribose phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732]
synonym: "deoxyribose phosphate breakdown" EXACT []
synonym: "deoxyribose phosphate catabolism" EXACT []
synonym: "deoxyribose phosphate degradation" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0046387
name: deoxyribose 1,5-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai]
synonym: "deoxyribose 1,5-bisphosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046389
name: deoxyribose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose." [GOC:ai]
synonym: "deoxyribose 5-phosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046390
name: ribose phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]
synonym: "ribose phosphate anabolism" EXACT []
synonym: "ribose phosphate biosynthesis" EXACT []
synonym: "ribose phosphate formation" EXACT []
synonym: "ribose phosphate synthesis" EXACT []
is_a: GO:0019693 ! ribose phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046391
name: 5-phosphoribose 1-diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai]
synonym: "5-phosphoribose 1-diphosphate metabolism" EXACT []
synonym: "PRPP metabolic process" EXACT []
xref: MetaCyc:PRPP-PWY
is_a: GO:0019693 ! ribose phosphate metabolic process

[Term]
id: GO:0046392
name: galactarate catabolic process
namespace: biological_process
alt_id: GO:0019582
def: "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid." [GOC:ai, GOC:pr]
synonym: "D-galactarate breakdown" RELATED []
synonym: "D-galactarate catabolic process" RELATED []
synonym: "D-galactarate catabolism" RELATED []
synonym: "D-galactarate degradation" RELATED []
synonym: "galactarate breakdown" EXACT []
synonym: "galactarate catabolism" EXACT []
synonym: "galactarate degradation" EXACT []
xref: MetaCyc:GALACTARDEG-PWY
is_a: GO:0019579 ! aldaric acid catabolic process
is_a: GO:0019580 ! galactarate metabolic process

[Term]
id: GO:0046394
name: carboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "carboxylic acid anabolism" EXACT []
synonym: "carboxylic acid biosynthesis" EXACT []
synonym: "carboxylic acid formation" EXACT []
synonym: "carboxylic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046395
name: carboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "carboxylic acid breakdown" EXACT []
synonym: "carboxylic acid catabolism" EXACT []
synonym: "carboxylic acid degradation" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046396
name: D-galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls." [GOC:ai, GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "D-galacturonate metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0019586 ! galacturonate metabolic process

[Term]
id: GO:0046397
name: galacturonate catabolic process
namespace: biological_process
alt_id: GO:0019587
def: "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid." [GOC:ai]
synonym: "galacturonate breakdown" EXACT []
synonym: "galacturonate catabolism" EXACT []
synonym: "galacturonate degradation" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046398
name: UDP-glucuronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
synonym: "UDP-glucuronate metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046399
name: glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid." [GOC:ai]
synonym: "glucuronate anabolism" EXACT []
synonym: "glucuronate biosynthesis" EXACT []
synonym: "glucuronate formation" EXACT []
synonym: "glucuronate synthesis" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046400
name: keto-3-deoxy-D-manno-octulosonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [GOC:ai, ISBN:0198506732]
synonym: "KDO metabolic process" EXACT [GOC:mah]
synonym: "KDO metabolism" EXACT [GOC:mah]
synonym: "keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT []
synonym: "ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732]
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046401
name: lipopolysaccharide core region metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains." [ISBN:0198506732]
synonym: "lipopolysaccharide core region metabolism" EXACT []
synonym: "LPS core region metabolic process" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
relationship: part_of GO:0008653 ! lipopolysaccharide metabolic process

[Term]
id: GO:0046402
name: O antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732]
synonym: "O antigen metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0046403
name: polynucleotide 3'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate." [RHEA:14113]
synonym: "2'(3')-polynucleotidase activity" RELATED [EC:3.1.3.32]
synonym: "5'-polynucleotidekinase 3'-phosphatase activity" RELATED [EC:3.1.3.32]
synonym: "deoxyribonucleate 3'-phosphatase activity" RELATED [EC:3.1.3.32]
synonym: "DNA 3'-phosphatase activity" RELATED [EC:3.1.3.32]
synonym: "polynucleotide 3'-phosphohydrolase activity" RELATED [EC:3.1.3.32]
xref: EC:3.1.3.32
xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN
xref: Reactome:R-HSA-5649705 "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)"
xref: RHEA:14113
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0046404
name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [RHEA:15669]
synonym: "ATP-dependent DNA kinase activity" EXACT []
synonym: "polydeoxyribonucleotide 5'-hydroxyl-kinase activity" BROAD []
xref: KEGG_REACTION:R03840
xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN
xref: RHEA:15669
is_a: GO:0051734 ! ATP-dependent polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0046405
name: glycerol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30, PMID:18307109]
synonym: "glycerol dehydrase activity" RELATED [EC:4.2.1.30]
synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" RELATED [EC:4.2.1.30]
synonym: "glycerol hydro-lyase activity" RELATED [EC:4.2.1.30]
xref: EC:4.2.1.30
xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN
xref: RHEA:19765
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0046406
name: magnesium protoporphyrin IX methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine." [RHEA:17809]
synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" RELATED [EC:2.1.1.11]
synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT []
synonym: "Mg-protoporphyrin IX methyltransferase activity" RELATED [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" RELATED [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" RELATED [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" RELATED [EC:2.1.1.11]
synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" RELATED [EC:2.1.1.11]
synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" RELATED [EC:2.1.1.11]
xref: EC:2.1.1.11
xref: KEGG_REACTION:R04237
xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN
xref: RHEA:17809
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046408
name: chlorophyll synthetase activity
namespace: molecular_function
alt_id: GO:0043787
def: "Catalysis of the reaction: chlorophyllide a + 2 H+ + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, RHEA:17317]
synonym: "chlorophyll synthase activity" EXACT []
synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT []
xref: EC:2.5.1.62
xref: KEGG_REACTION:R06284
xref: MetaCyc:RXN1F-66
xref: RHEA:17317
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0046409
name: p-coumarate 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+." [PMID:11429408, PMID:11891223]
synonym: "cytochrome P450 CYP98A3" NARROW []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0046410
name: obsolete 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959]
comment: This term was made obsolete because it was derived from an EC entry (EC:2.5.1.64) that has since been split into two entries.
synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity" EXACT []
is_obsolete: true
consider: GO:0070204
consider: GO:0070205

[Term]
id: GO:0046411
name: 2-keto-3-deoxygluconate transmembrane transport
namespace: biological_process
def: "The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators]
synonym: "2-keto-3-deoxygluconate transport" RELATED []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015749 ! monosaccharide transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0046412
name: phenylmercury acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai]
synonym: "phenylmercury acetate metabolism" EXACT []
is_a: GO:0018942 ! organometal metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0046413
name: obsolete organomercury catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "organomercury breakdown" EXACT []
synonym: "organomercury catabolism" EXACT []
synonym: "organomercury degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0046414
name: organomercury biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai]
synonym: "organomercury anabolism" EXACT []
synonym: "organomercury biosynthesis" EXACT []
synonym: "organomercury formation" EXACT []
synonym: "organomercury synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0018942 ! organometal metabolic process

[Term]
id: GO:0046415
name: urate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [ISBN:0198506732]
synonym: "urate metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0046416
name: D-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
synonym: "D-amino acid metabolism" EXACT []
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0046417
name: chorismate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid." [ISBN:0198506732]
synonym: "chorismate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046418
name: obsolete nopaline metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "nopaline metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0046419
name: obsolete octopine metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "octopine metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0046421
name: methylisocitrate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30, RHEA:16809]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" RELATED [EC:4.1.3.30]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" RELATED [EC:4.1.3.30]
synonym: "2-methylisocitrate lyase activity" EXACT []
synonym: "MICL" RELATED [EC:4.1.3.30]
xref: EC:4.1.3.30
xref: KEGG_REACTION:R00409
xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN
xref: RHEA:16809
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0046422
name: violaxanthin de-epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.23.5.1, GOC:ai, ISBN:0471331309]
synonym: "VDE" RELATED [EC:1.23.5.1]
synonym: "violaxanthin:ascorbate oxidoreductase activity" RELATED [EC:1.23.5.1]
xref: EC:1.23.5.1
xref: RHEA:32371
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0046423
name: allene-oxide cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6, RHEA:22592]
synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" RELATED [EC:5.3.99.6]
xref: EC:5.3.99.6
xref: KEGG_REACTION:R03402
xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN
xref: RHEA:22592
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0046424
name: ferulate 5-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351]
xref: MetaCyc:RXN-1121
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0046425
name: regulation of receptor signaling pathway via JAK-STAT
namespace: biological_process
alt_id: GO:0007262
alt_id: GO:2000364
def: "Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT." [GOC:bf]
synonym: "regulation of STAT protein import into nucleus" NARROW []
synonym: "regulation of STAT protein nuclear translocation" NARROW [GOC:obol]
synonym: "STAT protein import into nucleus" NARROW []
is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT
relationship: regulates GO:0007259 ! cell surface receptor signaling pathway via JAK-STAT

[Term]
id: GO:0046426
name: negative regulation of receptor signaling pathway via JAK-STAT
namespace: biological_process
alt_id: GO:2000365
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT." [GOC:bf]
synonym: "down regulation of JAK-STAT cascade" EXACT []
synonym: "down-regulation of JAK-STAT cascade" EXACT []
synonym: "downregulation of JAK-STAT cascade" EXACT []
synonym: "inhibition of JAK-STAT cascade" NARROW []
synonym: "negative regulation of STAT protein import into nucleus" NARROW []
synonym: "negative regulation of STAT protein nuclear translocation" NARROW [GOC:obol]
is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT
is_a: GO:1904893 ! negative regulation of receptor signaling pathway via STAT
relationship: negatively_regulates GO:0007259 ! cell surface receptor signaling pathway via JAK-STAT

[Term]
id: GO:0046427
name: positive regulation of receptor signaling pathway via JAK-STAT
namespace: biological_process
alt_id: GO:2000366
def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
synonym: "activation of JAK-STAT cascade" NARROW []
synonym: "positive regulation of STAT protein import into nucleus" NARROW []
synonym: "positive regulation of STAT protein nuclear translocation" NARROW [GOC:obol]
synonym: "stimulation of JAK-STAT cascade" NARROW []
synonym: "up regulation of JAK-STAT cascade" EXACT []
synonym: "up-regulation of JAK-STAT cascade" EXACT []
synonym: "upregulation of JAK-STAT cascade" EXACT []
is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT
is_a: GO:1904894 ! positive regulation of receptor signaling pathway via STAT
relationship: positively_regulates GO:0007259 ! cell surface receptor signaling pathway via JAK-STAT

[Term]
id: GO:0046428
name: 1,4-dihydroxy-2-naphthoate polyprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H+ = a 2-demethylmenaquinol + CO2 + diphosphate." [RHEA:26478]
synonym: "1,4-dihydroxy-2-naphtoate prenyltransferase activity" EXACT []
xref: EC:2.5.1.74
xref: MetaCyc:RXN-11047
xref: RHEA:26478
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0046429
name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin." [EC:1.17.7.1, PMID:11752431]
synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity" EXACT systematic_synonym [EC:1.17.7.1]
synonym: "(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity" BROAD [EC:1.17.7.1]
synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" BROAD [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP]
synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" BROAD [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP]
xref: EC:1.17.7.1
xref: KEGG_REACTION:R08689
xref: MetaCyc:RXN0-882
xref: RHEA:26119
is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

[Term]
id: GO:0046430
name: non-phosphorylated glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving non-phosphorylated forms of glucose." [GOC:ai]
synonym: "non-phosphorylated glucose metabolism" EXACT []
is_a: GO:0006006 ! glucose metabolic process

[Term]
id: GO:0046431
name: (R)-4-hydroxymandelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate)." [GOC:ai, ISBN:0198506732]
synonym: "(R)-4-hydroxymandelate metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0046432
name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process

[Term]
id: GO:0046433
name: 2-aminoethylphosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms." [GOC:ai, PMID:12107130]
synonym: "2-aminoethylphosphonate metabolism" EXACT []
synonym: "2-phosphonoethylamine metabolic process" EXACT []
synonym: "2-phosphonoethylamine metabolism" EXACT []
synonym: "ciliatine metabolic process" EXACT []
synonym: "ciliatine metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0046434
name: organophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]
synonym: "organophosphate breakdown" EXACT []
synonym: "organophosphate catabolism" EXACT []
synonym: "organophosphate degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0046435
name: 3-(3-hydroxy)phenylpropionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai]
synonym: "3-(3-hydroxy)phenylpropionate metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0046436
name: D-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid." [GOC:ai, GOC:jsg]
synonym: "D-alanine metabolism" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046437
name: D-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
synonym: "D-amino acid anabolism" EXACT []
synonym: "D-amino acid biosynthesis" EXACT []
synonym: "D-amino acid formation" EXACT []
synonym: "D-amino acid synthesis" EXACT []
is_a: GO:0046416 ! D-amino acid metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0046438
name: D-cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:ai]
synonym: "D-cysteine metabolism" EXACT []
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046439
name: L-cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-cysteine metabolism" EXACT []
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0046440
name: L-lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-lysine metabolism" EXACT []
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0046441
name: D-lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "D-lysine metabolism" EXACT []
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046442
name: aerobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
synonym: "aerobactin metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0046443
name: FAD metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide." [PMID:20822113]
synonym: "FAD metabolism" EXACT []
synonym: "oxidized flavin adenine dinucleotide metabolic process" EXACT []
synonym: "oxidized flavin adenine dinucleotide metabolism" EXACT []
synonym: "oxidized flavin-adenine dinucleotide metabolic process" EXACT []
synonym: "oxidized flavin-adenine dinucleotide metabolism" EXACT []
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process

[Term]
id: GO:0046444
name: FMN metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, PMID:20822113]
synonym: "FMN metabolism" EXACT []
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process

[Term]
id: GO:0046445
name: benzyl isoquinoline alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732]
synonym: "benzyl isoquinoline alkaloid metabolism" EXACT []
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0046446
name: purine alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai]
synonym: "purine alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0046447
name: terpenoid indole alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai]
synonym: "terpenoid indole alkaloid metabolism" EXACT []
is_a: GO:0035834 ! indole alkaloid metabolic process

[Term]
id: GO:0046448
name: tropane alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732]
synonym: "tropane alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process

[Term]
id: GO:0046449
name: creatinine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732]
synonym: "creatinine metabolism" EXACT []
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:0046450
name: dethiobiotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms." [ISBN:0198506732]
synonym: "desthiobiotin metabolic process" EXACT []
synonym: "desthiobiotin metabolism" EXACT []
synonym: "dethiobiotin metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0046451
name: diaminopimelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ai, ISBN:0198506732]
synonym: "diaminopimelate metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:0046452
name: dihydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate." [ISBN:0198506732]
synonym: "dihydrofolate metabolism" EXACT []
synonym: "dihydrofolate reduction" NARROW []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046453
name: dipyrrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [PMID:17430001]
synonym: "dipyrrin metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0046454
name: dimethylsilanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:ai]
synonym: "dimethylsilanediol metabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0046455
name: organosilicon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon." [GOC:ai]
synonym: "organosilicon breakdown" EXACT []
synonym: "organosilicon catabolism" EXACT []
synonym: "organosilicon degradation" EXACT []
synonym: "organosilicone catabolic process" EXACT []
synonym: "organosilicone catabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046456
name: icosanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732]
synonym: "eicosanoid biosynthesis" EXACT []
synonym: "eicosanoid biosynthetic process" EXACT []
synonym: "eoxin biosynthesis" EXACT []
synonym: "eoxin synthesis" EXACT []
synonym: "icosanoid anabolism" EXACT []
synonym: "icosanoid biosynthesis" EXACT []
synonym: "icosanoid formation" EXACT []
synonym: "icosanoid synthesis" EXACT []
xref: Wikipedia:Eicosanoid
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0046457
name: prostanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." [GOC:ai]
synonym: "prostanoid anabolism" EXACT []
synonym: "prostanoid biosynthesis" EXACT []
synonym: "prostanoid formation" EXACT []
synonym: "prostanoid synthesis" EXACT []
xref: Wikipedia:Prostanoid#Biosynthesis
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0006692 ! prostanoid metabolic process
is_a: GO:0046456 ! icosanoid biosynthetic process

[Term]
id: GO:0046458
name: hexadecanal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde." [PMID:25047030]
synonym: "hexadecanal metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process

[Term]
id: GO:0046459
name: short-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [Wikipedia:Fatty_acid_metabolism]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "short-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0046460
name: neutral lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai]
synonym: "neutral lipid anabolism" EXACT []
synonym: "neutral lipid biosynthesis" EXACT []
synonym: "neutral lipid formation" EXACT []
synonym: "neutral lipid synthesis" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046461
name: neutral lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai]
synonym: "neutral lipid breakdown" EXACT []
synonym: "neutral lipid catabolism" EXACT []
synonym: "neutral lipid degradation" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process

[Term]
id: GO:0046462
name: monoacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732]
synonym: "monoacylglycerol metabolism" EXACT []
synonym: "monoglyceride metabolic process" EXACT []
synonym: "monoglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0046463
name: acylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]
synonym: "acylglycerol anabolism" EXACT []
synonym: "acylglycerol biosynthesis" EXACT []
synonym: "acylglycerol formation" EXACT []
synonym: "acylglycerol synthesis" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process
is_a: GO:0045017 ! glycerolipid biosynthetic process
is_a: GO:0046460 ! neutral lipid biosynthetic process

[Term]
id: GO:0046464
name: acylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]
synonym: "acylglycerol breakdown" EXACT []
synonym: "acylglycerol catabolism" EXACT []
synonym: "acylglycerol degradation" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process
is_a: GO:0046461 ! neutral lipid catabolic process
is_a: GO:0046503 ! glycerolipid catabolic process

[Term]
id: GO:0046465
name: dolichyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes." [ISBN:0198506732]
synonym: "dolichyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:0046466
name: membrane lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
synonym: "membrane lipid breakdown" EXACT []
synonym: "membrane lipid catabolism" EXACT []
synonym: "membrane lipid degradation" EXACT []
synonym: "membrane lipid peroxidation" BROAD [GOC:tb]
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0016042 ! lipid catabolic process

[Term]
id: GO:0046467
name: membrane lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
synonym: "membrane lipid anabolism" EXACT []
synonym: "membrane lipid biosynthesis" EXACT []
synonym: "membrane lipid formation" EXACT []
synonym: "membrane lipid synthesis" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046468
name: phosphatidyl-N-monomethylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria." [PMID:35071223]
synonym: "phosphatidyl-N-monomethylethanolamine metabolism" EXACT []
synonym: "PMME metabolic process" EXACT []
synonym: "PMME metabolism" EXACT []
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0046469
name: platelet activating factor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684]
synonym: "PAF metabolic process" EXACT []
synonym: "PAF metabolism" EXACT []
synonym: "platelet activating factor metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0046485 ! ether lipid metabolic process

[Term]
id: GO:0046470
name: phosphatidylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]
synonym: "phosphatidylcholine metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046471
name: phosphatidylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732]
synonym: "phosphatidylglycerol metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046473
name: phosphatidic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]
synonym: "phosphatidic acid metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046474
name: glycerophospholipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
synonym: "glycerophospholipid anabolism" EXACT []
synonym: "glycerophospholipid biosynthesis" EXACT []
synonym: "glycerophospholipid formation" EXACT []
synonym: "glycerophospholipid synthesis" EXACT []
synonym: "phosphoglyceride biosynthesis" EXACT []
synonym: "phosphoglyceride biosynthetic process" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0045017 ! glycerolipid biosynthetic process

[Term]
id: GO:0046475
name: glycerophospholipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
synonym: "glycerophospholipid breakdown" EXACT []
synonym: "glycerophospholipid catabolism" EXACT []
synonym: "glycerophospholipid degradation" EXACT []
synonym: "phosphoglyceride catabolic process" EXACT []
synonym: "phosphoglyceride catabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0046503 ! glycerolipid catabolic process

[Term]
id: GO:0046476
name: glycosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai]
synonym: "glycosylceramide anabolism" EXACT []
synonym: "glycosylceramide biosynthesis" EXACT []
synonym: "glycosylceramide formation" EXACT []
synonym: "glycosylceramide synthesis" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0046477
name: glycosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai]
synonym: "glycosylceramide breakdown" EXACT []
synonym: "glycosylceramide catabolism" EXACT []
synonym: "glycosylceramide degradation" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0046479 ! glycosphingolipid catabolic process
is_a: GO:0046514 ! ceramide catabolic process

[Term]
id: GO:0046478
name: lactosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732]
synonym: "lactosylceramide metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0046479
name: glycosphingolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732]
synonym: "glycosphingolipid breakdown" EXACT []
synonym: "glycosphingolipid catabolism" EXACT []
synonym: "glycosphingolipid degradation" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process
is_a: GO:0019377 ! glycolipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0046480
name: galactolipid galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184]
synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.184]
synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184]
synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184]
synonym: "galactolipid-galactolipid galactosyltransferase activity" RELATED [EC:2.4.1.184]
synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT []
synonym: "GGGT activity" RELATED [EC:2.4.1.184]
synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184]
xref: EC:2.4.1.184
xref: MetaCyc:RXN-1226
xref: RHEA:15921
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0046481
name: digalactosyldiacylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H+ + UDP." [EC:2.4.1.241, RHEA:10520]
synonym: "DGD1" NARROW []
synonym: "DGD2" NARROW []
synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241]
synonym: "UDP-galactose-dependent DGDG synthase activity" RELATED [EC:2.4.1.241]
synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" RELATED [EC:2.4.1.241]
synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.241]
synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT []
xref: EC:2.4.1.241
xref: KEGG_REACTION:R04469
xref: MetaCyc:RXN-1225
xref: RHEA:10520
xref: Wikipedia:Digalactosyldiacylglycerol_synthase
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046482
name: para-aminobenzoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, PMID:11377864, PMID:11960743]
synonym: "4-aminobenzoic acid metabolic process" EXACT []
synonym: "4-aminobenzoic acid metabolism" EXACT []
synonym: "p-aminobenzoic acid metabolic process" EXACT []
synonym: "p-aminobenzoic acid metabolism" EXACT []
synonym: "PABA metabolic process" EXACT []
synonym: "PABA metabolism" EXACT []
synonym: "para-aminobenzoic acid metabolism" EXACT []
synonym: "vitamin Bx metabolic process" EXACT []
synonym: "vitamin Bx metabolism" EXACT []
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0046483
name: obsolete heterocycle metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0008152

[Term]
id: GO:0046484
name: oxazole or thiazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [GOC:curators]
synonym: "oxazole or thiazole metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0046485
name: ether lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [ISBN:0198506732, PMID:15337120]
synonym: "ether lipid metabolism" EXACT []
synonym: "plasmalogen metabolic process" NARROW []
xref: Wikipedia:Ether_lipid
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0006662 ! glycerol ether metabolic process

[Term]
id: GO:0046486
name: glycerolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569]
synonym: "glycerolipid metabolism" EXACT []
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0046487
name: glyoxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]
synonym: "glyoxylate metabolism" EXACT []
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0046488
name: phosphatidylinositol metabolic process
namespace: biological_process
alt_id: GO:0030384
def: "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]
synonym: "phosphatidylinositol metabolism" EXACT []
synonym: "phosphoinositide metabolic process" EXACT []
synonym: "phosphoinositide metabolism" EXACT []
synonym: "PtdIns metabolic process" EXACT []
synonym: "PtdIns metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046490
name: isopentenyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732]
subset: goslim_pir
synonym: "IPP metabolic process" EXACT []
synonym: "IPP metabolism" EXACT []
synonym: "isopentenyl diphosphate metabolism" EXACT []
synonym: "isopentenyl pyrophosphate metabolic process" EXACT []
synonym: "isopentenyl pyrophosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:0046491
name: L-methylmalonyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "L-methylmalonyl-CoA metabolism" EXACT []
is_a: GO:0006637 ! acyl-CoA metabolic process

[Term]
id: GO:0046492
name: heme B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, PMID:29414780]
synonym: "haem B metabolic process" EXACT []
synonym: "haem B metabolism" EXACT []
synonym: "heme B metabolism" EXACT []
synonym: "protoheme metabolic process" EXACT []
synonym: "protoheme metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046493
name: lipid A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common." [ISBN:0198506732, PMID:20974832, PMID:22216004]
synonym: "lipid A metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process

[Term]
id: GO:0046494
name: rhizobactin 1021 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [PMID:11274118]
synonym: "rhizobactin 1021 metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0046495
name: nicotinamide riboside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732]
synonym: "N-ribosylnicotinamide metabolic process" EXACT []
synonym: "nicotinamide riboside metabolism" EXACT []
is_a: GO:0070637 ! pyridine nucleoside metabolic process

[Term]
id: GO:0046496
name: nicotinamide nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732]
synonym: "nicotinamide nucleotide metabolism" EXACT []
is_a: GO:0019362 ! pyridine nucleotide metabolic process

[Term]
id: GO:0046497
name: nicotinate nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin)." [ISBN:0198506732]
synonym: "nicotinate nucleotide metabolism" EXACT []
is_a: GO:0019362 ! pyridine nucleotide metabolic process

[Term]
id: GO:0046498
name: S-adenosylhomocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732]
synonym: "S-adenosylhomocysteine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0046499
name: S-adenosylmethioninamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah]
synonym: "S-adenosylmethioninamine metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046500
name: S-adenosylmethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]
synonym: "S-adenosyl methionine metabolic process" EXACT []
synonym: "S-adenosyl methionine metabolism" EXACT []
synonym: "S-adenosylmethionine metabolism" EXACT []
synonym: "SAM metabolic process" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0046501
name: protoporphyrinogen IX metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation." [ISBN:0198506732]
comment: See also the molecular function term 'ferrochelatase activity ; GO:0004325'.
synonym: "protoporphyrinogen IX metabolism" EXACT []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process

[Term]
id: GO:0046502
name: uroporphyrinogen III metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds." [GOC:ai]
synonym: "uroporphyrinogen III metabolism" EXACT []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046503
name: glycerolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
synonym: "glycerolipid breakdown" EXACT []
synonym: "glycerolipid catabolism" EXACT []
synonym: "glycerolipid degradation" EXACT []
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0046504
name: glycerol ether biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai]
synonym: "glycerol ether anabolism" EXACT []
synonym: "glycerol ether biosynthesis" EXACT []
synonym: "glycerol ether formation" EXACT []
synonym: "glycerol ether synthesis" EXACT []
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0046505
name: sulfolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667]
synonym: "sulfolipid metabolism" EXACT []
synonym: "sulpholipid metabolic process" EXACT []
synonym: "sulpholipid metabolism" EXACT []
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0046506
name: sulfolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667]
synonym: "sulfolipid anabolism" EXACT []
synonym: "sulfolipid biosynthesis" EXACT []
synonym: "sulfolipid formation" EXACT []
synonym: "sulfolipid synthesis" EXACT []
synonym: "sulpholipid biosynthesis" EXACT []
synonym: "sulpholipid biosynthetic process" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046505 ! sulfolipid metabolic process

[Term]
id: GO:0046507
name: UDPsulfoquinovose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfite + UDP-D-glucose = H2O + UDP-6-sulfoquinovose." [EC:3.13.1.1, RHEA:13197]
synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT []
synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" RELATED [EC:3.13.1.1]
synonym: "UDP-sulfoquinovose synthase activity" RELATED [EC:3.13.1.1]
synonym: "UDPsulphoquinovose synthase activity" EXACT []
xref: EC:3.13.1.1
xref: KEGG_REACTION:R05775
xref: MetaCyc:RXN-1223
xref: RHEA:13197
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0046508
name: hydrolase activity, acting on carbon-sulfur bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl]
synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT []
xref: EC:3.13.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0046509
name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H+ + UDP." [EC:2.4.1.46, RHEA:14945]
synonym: "1-beta-MGDG activity" RELATED [EC:2.4.1.46]
synonym: "1beta-MGDG" RELATED [EC:2.4.1.46]
synonym: "MGDG synthase activity" EXACT []
synonym: "monogalactosyldiacylglycerol synthase activity" EXACT []
synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT []
synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.46]
synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT []
synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.46]
synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT []
xref: EC:2.4.1.46
xref: KEGG_REACTION:R02691
xref: MetaCyc:2.4.1.46-RXN
xref: RHEA:14945
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046510
name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224]
synonym: "sulfolipid synthase" BROAD []
synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT []
xref: MetaCyc:RXN-1224
xref: RHEA:49468
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0046511
name: sphinganine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
synonym: "dihydrosphingosine biosynthesis" EXACT []
synonym: "dihydrosphingosine biosynthetic process" EXACT []
synonym: "sphinganine anabolism" EXACT []
synonym: "sphinganine biosynthesis" EXACT []
synonym: "sphinganine formation" EXACT []
synonym: "sphinganine synthesis" EXACT []
is_a: GO:0006667 ! sphinganine metabolic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0046512
name: sphingosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732]
synonym: "sphingosine anabolism" EXACT []
synonym: "sphingosine biosynthesis" EXACT []
synonym: "sphingosine formation" EXACT []
synonym: "sphingosine synthesis" EXACT []
is_a: GO:0006670 ! sphingosine metabolic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0046513
name: ceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]
synonym: "ceramide anabolism" EXACT []
synonym: "ceramide biosynthesis" EXACT []
synonym: "ceramide formation" EXACT []
synonym: "ceramide synthesis" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0046514
name: ceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]
synonym: "ceramide breakdown" EXACT []
synonym: "ceramide catabolism" EXACT []
synonym: "ceramide degradation" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0046516
name: hypusine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ai]
synonym: "hypusine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0046517
name: octamethylcyclotetrasiloxane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, PMID:10224038]
synonym: "octamethylcyclotetrasiloxane breakdown" EXACT []
synonym: "octamethylcyclotetrasiloxane catabolism" EXACT []
synonym: "octamethylcyclotetrasiloxane degradation" EXACT []
is_a: GO:0046455 ! organosilicon catabolic process
is_a: GO:0046518 ! octamethylcyclotetrasiloxane metabolic process

[Term]
id: GO:0046518
name: octamethylcyclotetrasiloxane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, https://doi.org/10.1177/0748233716670061]
synonym: "octamethylcyclotetrasiloxane metabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process

[Term]
id: GO:0046519
name: sphingoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732]
synonym: "sphingoid base metabolic process" EXACT []
synonym: "sphingoid base metabolism" EXACT []
synonym: "sphingoid metabolism" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0046520
name: sphingoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732]
synonym: "sphingoid anabolism" EXACT []
synonym: "sphingoid biosynthesis" EXACT []
synonym: "sphingoid formation" EXACT []
synonym: "sphingoid synthesis" EXACT []
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0046521
name: sphingoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732]
synonym: "sphingoid breakdown" EXACT []
synonym: "sphingoid catabolism" EXACT []
synonym: "sphingoid degradation" EXACT []
is_a: GO:0030149 ! sphingolipid catabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0046522
name: S-methyl-5-thioribose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+." [EC:2.7.1.100, RHEA:22312]
synonym: "5-methylthioribose kinase (phosphorylating)" RELATED [EC:2.7.1.100]
synonym: "5-methylthioribose kinase activity" EXACT []
synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" RELATED [EC:2.7.1.100]
synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" RELATED [EC:2.7.1.100]
synonym: "methylthioribose kinase activity" RELATED [EC:2.7.1.100]
synonym: "MTR kinase activity" RELATED [EC:2.7.1.100]
xref: EC:2.7.1.100
xref: KEGG_REACTION:R04143
xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN
xref: RHEA:22312
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0046523
name: S-methyl-5-thioribose-1-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [RHEA:19989]
synonym: "1-phospho-5'-S-methylthioribose isomerase activity" RELATED [EC:5.3.1.23]
synonym: "1-PMTR isomerase activity" RELATED [EC:5.3.1.23]
synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.23]
synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT []
synonym: "methylthioribose 1-phosphate isomerase activity" RELATED [EC:5.3.1.23]
synonym: "MTR-1-P isomerase activity" RELATED [EC:5.3.1.23]
synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.23]
synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.23]
synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.23]
synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.23]
xref: EC:5.3.1.23
xref: KEGG_REACTION:R04420
xref: MetaCyc:5.3.1.23-RXN
xref: Reactome:R-HSA-1237096 "Methylthio-ribose-P = Methylthio-ribulose-P"
xref: Reactome:R-HSA-1299507 "Methylthio-ribulose-P = Methylthio-ribose-P"
xref: RHEA:19989
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0046524
name: sucrose-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14]
synonym: "SPS" RELATED [EC:2.4.1.14]
synonym: "sucrose 6-phosphate synthase activity" RELATED [EC:2.4.1.14]
synonym: "sucrose phosphate synthetase activity" RELATED [EC:2.4.1.14]
synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.14]
synonym: "sucrosephosphate-UDP glucosyltransferase activity" RELATED [EC:2.4.1.14]
synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.14]
synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.14]
synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.14]
synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.14]
synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" RELATED [EC:2.4.1.14]
xref: EC:2.4.1.14
xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN
xref: RHEA:22172
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0046525
name: xylosylprotein 4-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133]
synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133]
synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" RELATED [EC:2.4.1.133]
synonym: "UDP-D-galactose:xylose galactosyltransferase activity" RELATED [EC:2.4.1.133]
synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.133]
synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT []
synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.133]
synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" RELATED [EC:2.4.1.133]
xref: EC:2.4.1.133
xref: MetaCyc:2.4.1.133-RXN
xref: Reactome:R-HSA-1889981 "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker"
xref: Reactome:R-HSA-3560804 "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker"
xref: RHEA:15297
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0046526
name: D-xylulose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH." [RHEA:20433]
synonym: "xylitol dehydrogenase activity" EXACT [EC:1.1.1.9]
xref: EC:1.1.1.9
xref: KEGG_REACTION:R01896
xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN
xref: Reactome:R-HSA-5662471 "SORD tetramer oxidizes xylitol to D-xylulose"
xref: RHEA:20433
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0046527
name: glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0046528
name: imaginal disc fusion
namespace: biological_process
def: "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0046529
name: imaginal disc fusion, thorax closure
namespace: biological_process
def: "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0046528 ! imaginal disc fusion

[Term]
id: GO:0046530
name: photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0007467
def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0046532
name: regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045673
def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046533
name: negative regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045674
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "down regulation of photoreceptor cell differentiation" EXACT []
synonym: "down regulation of photoreceptor differentiation" EXACT []
synonym: "down-regulation of photoreceptor cell differentiation" EXACT []
synonym: "down-regulation of photoreceptor differentiation" EXACT []
synonym: "downregulation of photoreceptor cell differentiation" EXACT []
synonym: "downregulation of photoreceptor differentiation" EXACT []
synonym: "inhibition of photoreceptor cell differentiation" NARROW []
synonym: "inhibition of photoreceptor differentiation" NARROW []
synonym: "negative regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046534
name: positive regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045675
def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "activation of photoreceptor cell differentiation" NARROW []
synonym: "activation of photoreceptor differentiation" NARROW []
synonym: "positive regulation of photoreceptor differentiation" EXACT []
synonym: "stimulation of photoreceptor cell differentiation" NARROW []
synonym: "stimulation of photoreceptor differentiation" NARROW []
synonym: "up regulation of photoreceptor cell differentiation" EXACT []
synonym: "up regulation of photoreceptor differentiation" EXACT []
synonym: "up-regulation of photoreceptor cell differentiation" EXACT []
synonym: "up-regulation of photoreceptor differentiation" EXACT []
synonym: "upregulation of photoreceptor cell differentiation" EXACT []
synonym: "upregulation of photoreceptor differentiation" EXACT []
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046535
name: detection of chemical stimulus involved in sensory perception of umami taste
namespace: biological_process
def: "The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai, GOC:dos, PMID:11894099]
synonym: "perception of umami taste, detection of chemical stimulus" EXACT []
synonym: "perception of umami taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of umami taste" EXACT []
synonym: "sensory detection of umami taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of umami taste" EXACT []
synonym: "sensory transduction of umami taste" EXACT []
synonym: "umami taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050917 ! sensory perception of umami taste

[Term]
id: GO:0046536
name: dosage compensation complex
namespace: cellular_component
def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah]
subset: goslim_pir
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000785 ! chromatin
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0046537
name: obsolete 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [GOC:rynl]
comment: The reason for obsoletion is that this term is unnecessarily specific.
is_obsolete: true
replaced_by: GO:0004619

[Term]
id: GO:0046538
name: obsolete 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction mechanism uses 2,3-bisphosphoglycerate as a phosphate donor." [GOC:rynl]
comment: The reason for obsoletion is that this term is unnecessarily specific.
is_obsolete: true
replaced_by: GO:0004619

[Term]
id: GO:0046539
name: histamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.8, RHEA:19301]
synonym: "histamine 1-methyltransferase activity" RELATED [EC:2.1.1.8]
synonym: "histamine methyltransferase activity" RELATED [EC:2.1.1.8]
synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8]
synonym: "imidazolemethyltransferase activity" RELATED [EC:2.1.1.8]
synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" RELATED [EC:2.1.1.8]
synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" RELATED [EC:2.1.1.8]
xref: EC:2.1.1.8
xref: KEGG_REACTION:R02155
xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-175993 "HNMT transfers CH3 group from AdoMet to Hist"
xref: RHEA:19301
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046540
name: U4/U6 x U5 tri-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]
synonym: "U4/U6.U5 snRNP complex" EXACT []
is_a: GO:0097526 ! spliceosomal tri-snRNP complex

[Term]
id: GO:0046541
name: saliva secretion
namespace: biological_process
def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [GOC:curators, UBERON:0001836]
synonym: "salivation" EXACT []
xref: Wikipedia:Salivation
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0022600 ! digestive system process
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0046542
name: obsolete alpha-factor export
namespace: biological_process
def: "OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell." [GOC:ai]
comment: This term was made obsolete because it is a gene product based term and it does not involve a unique process.
synonym: "alpha-factor export" EXACT []
is_obsolete: true
consider: GO:0015833

[Term]
id: GO:0046543
name: development of secondary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045136 ! development of secondary sexual characteristics

[Term]
id: GO:0046544
name: development of secondary male sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045136 ! development of secondary sexual characteristics
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0046545
name: development of primary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0046546
name: development of primary male sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0046547
name: trans-aconitate 3-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.145, RHEA:22200]
synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" RELATED [EC:2.1.1.145]
xref: EC:2.1.1.145
xref: KEGG_REACTION:R05764
xref: MetaCyc:2.1.1.145-RXN
xref: RHEA:22200
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046548
name: retinal rod cell development
namespace: biological_process
def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0060221 ! retinal rod cell differentiation

[Term]
id: GO:0046549
name: retinal cone cell development
namespace: biological_process
def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0042670 ! retinal cone cell differentiation

[Term]
id: GO:0046550
name: obsolete (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine
namespace: biological_process
def: "OBSOLETE. The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7." [RESID:AA0328]
comment: This term was obsoleted because it represents a molecular function.
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine" EXACT []
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine" EXACT []
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine" EXACT []
is_obsolete: true

[Term]
id: GO:0046551
name: retinal cone cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:mtg_sensu, PMID:3076112, PMID:3937883]
is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment
relationship: part_of GO:0042670 ! retinal cone cell differentiation

[Term]
id: GO:0046552
name: photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046553
name: D-malate dehydrogenase (decarboxylating) (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-malate + NAD+ = CO2 + NADH + pyruvate." [RHEA:18365]
synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.83]
synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83]
synonym: "D-malate dehydrogenase activity" RELATED [EC:1.1.1.83]
synonym: "D-malic enzyme" RELATED [EC:1.1.1.83]
xref: EC:1.1.1.83
xref: KEGG_REACTION:R00215
xref: MetaCyc:1.1.1.83-RXN
xref: RHEA:18365
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046554
name: L-malate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [RHEA:10824]
synonym: "(S)-malate:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.82, KEGG_REACTION:R00343]
synonym: "malate NADP dehydrogenase activity" RELATED [EC:1.1.1.82]
synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.82]
synonym: "NADP malate dehydrogenase activity" RELATED [EC:1.1.1.82]
synonym: "NADP-linked malate dehydrogenase activity" RELATED [EC:1.1.1.82]
synonym: "NADP-malate dehydrogenase activity" RELATED [EC:1.1.1.82]
xref: EC:1.1.1.82
xref: KEGG_REACTION:R00343
xref: MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:10824
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046555
name: acetylxylan esterase activity
namespace: molecular_function
def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72]
xref: EC:3.1.1.72
xref: MetaCyc:3.1.1.72-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0046556
name: alpha-L-arabinofuranosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]
synonym: "alpha-arabinofuranosidase activity" RELATED [EC:3.2.1.55]
synonym: "alpha-arabinosidase activity" RELATED [EC:3.2.1.55]
synonym: "alpha-L-arabinanase activity" RELATED [EC:3.2.1.55]
synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" RELATED [EC:3.2.1.55]
synonym: "alpha-L-arabinofuranoside hydrolase activity" RELATED [EC:3.2.1.55]
synonym: "alpha-L-arabinosidase activity" RELATED [EC:3.2.1.55]
synonym: "alpha-N-arabinofuranosidase activity" RELATED []
synonym: "arabinofuranosidase activity" RELATED [EC:3.2.1.55]
synonym: "arabinosidase activity" RELATED [EC:3.2.1.55]
synonym: "L-arabinosidase activity" RELATED [EC:3.2.1.55]
synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT []
xref: EC:3.2.1.55
xref: MetaCyc:3.2.1.55-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046557
name: glucan endo-1,6-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans." [EC:3.2.1.75]
synonym: "1,6-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.75]
synonym: "beta-1,6-glucan 6-glucanohydrolase activity" RELATED [EC:3.2.1.75]
synonym: "beta-1,6-glucan hydrolase activity" RELATED [EC:3.2.1.75]
synonym: "beta-1,6-glucanase activity" RELATED [EC:3.2.1.75]
synonym: "beta-1,6-glucanase-pustulanase activity" RELATED [EC:3.2.1.75]
synonym: "beta-1->6-glucan hydrolase activity" RELATED [EC:3.2.1.75]
synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT []
synonym: "endo-(1->6)-beta-D-glucanase activity" RELATED [EC:3.2.1.75]
synonym: "endo-1,6-beta-D-glucanase activity" RELATED [EC:3.2.1.75]
synonym: "endo-1,6-beta-glucanase activity" RELATED [EC:3.2.1.75]
synonym: "endo-beta-1,6-glucanase activity" RELATED [EC:3.2.1.75]
xref: EC:3.2.1.75
xref: MetaCyc:3.2.1.75-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0046558
name: arabinan endo-1,5-alpha-L-arabinosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans." [EC:3.2.1.99]
synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" RELATED [EC:3.2.1.99]
synonym: "endo-1,5-alpha-L-arabinanase activity" RELATED [EC:3.2.1.99]
synonym: "endo-alpha-1,5-arabanase activity" RELATED [EC:3.2.1.99]
synonym: "endo-arabanase activity" RELATED [EC:3.2.1.99]
xref: EC:3.2.1.99
xref: MetaCyc:3.2.1.99-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046559
name: alpha-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139]
synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" RELATED [EC:3.2.1.139]
synonym: "alpha-glucosiduronase activity" RELATED [EC:3.2.1.139]
xref: EC:3.2.1.139
xref: MetaCyc:3.2.1.139-RXN
xref: RHEA:20005
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046560
name: obsolete scytalidopepsin B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32]
comment: This term was made obsolete because it represents a gene product.
synonym: "Ganoderma lucidum aspartic proteinase activity" RELATED [EC:3.4.23.32]
synonym: "Ganoderma lucidum carboxyl proteinase activity" RELATED [EC:3.4.23.32]
synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32]
synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32]
synonym: "scytalidopepsin B activity" EXACT []
synonym: "SLB" RELATED [EC:3.4.23.32]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0046561
name: obsolete penicillopepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20]
comment: This term was made obsolete because it represents a gene product.
synonym: "acid protease A" EXACT []
synonym: "Penicillium aspartic proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium caseicolum aspartic proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium citrinum acid proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium citrinum aspartic proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium cyclopium acid proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium duponti aspartic proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium expansum acid proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium expansum aspartic proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium janthinellum acid proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic protease activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic proteinase activity" RELATED [EC:3.4.23.20]
synonym: "Penicillium roqueforti acid proteinase activity" RELATED [EC:3.4.23.20]
synonym: "penicillopepsin activity" EXACT []
synonym: "peptidase A activity" BROAD [EC:3.4.23.20]
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0046562
name: beta-D-glucose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [RHEA:11428]
synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" RELATED [EC:1.1.3.4]
synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.4]
synonym: "beta-D-glucose:quinone oxidoreductase activity" RELATED [EC:1.1.3.4]
synonym: "corylophyline" RELATED [EC:1.1.3.4]
synonym: "D-glucose oxidase activity" RELATED [EC:1.1.3.4]
synonym: "D-glucose-1-oxidase activity" RELATED [EC:1.1.3.4]
synonym: "deoxin-1" RELATED [EC:1.1.3.4]
synonym: "glucose aerodehydrogenase activity" RELATED [EC:1.1.3.4]
synonym: "glucose oxidase activity" EXACT []
synonym: "glucose oxyhydrase activity" RELATED [EC:1.1.3.4]
synonym: "GOD activity" RELATED [EC:1.1.3.4]
synonym: "microcid" RELATED [EC:1.1.3.4]
synonym: "penatin" RELATED [EC:1.1.3.4]
xref: EC:1.1.3.4
xref: KEGG_REACTION:R01522
xref: MetaCyc:GLUCOSE-OXIDASE-RXN
xref: RHEA:11428
is_a: GO:0047979 ! hexose oxidase activity

[Term]
id: GO:0046563
name: obsolete methanol oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [GOC:curators]
comment: This term was obsoleted because EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13).
is_obsolete: true
replaced_by: GO:0047639

[Term]
id: GO:0046564
name: oxalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + oxalate = CO2 + formate." [EC:4.1.1.2, RHEA:16509]
synonym: "oxalate carboxy-lyase (formate-forming)" RELATED [EC:4.1.1.2]
synonym: "oxalate carboxy-lyase activity" RELATED [EC:4.1.1.2]
xref: EC:4.1.1.2
xref: KEGG_REACTION:R00522
xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN
xref: RHEA:16509
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0046565
name: 3-dehydroshikimate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.118, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN]
xref: EC:4.2.1.118
xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN
xref: RHEA:24848
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0046566
name: obsolete DOPA dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071]
comment: This term was obsoleted because it represents the same reaction as stizolobate synthase activity ; GO:0050297.
synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT []
is_obsolete: true
replaced_by: GO:0050297

[Term]
id: GO:0046567
name: aphidicolan-16 beta-ol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate." [EC:4.2.3.42, PMID:12149019]
synonym: "9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming)" RELATED [EC:4.2.3.42]
xref: EC:4.2.3.42
xref: KEGG_REACTION:R06313
xref: MetaCyc:RXN-10631
xref: RHEA:26213
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0046568
name: 3-methylbutanal reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265]
synonym: "3-methylbutanal reductase [NAD(P)] activity" RELATED [EC:1.1.1.265]
synonym: "3-methylbutanol:NAD(P) oxidoreductase activity" EXACT []
synonym: "3-methylbutyraldehyde reductase activity" EXACT []
synonym: "isoamyl alcohol oxidase activity" EXACT []
xref: EC:1.1.1.265
xref: MetaCyc:1.1.1.265-RXN
is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0046569
name: glyoxal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [PMID:11733005]
synonym: "GLOX" EXACT []
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0046570
name: methylthioribulose 1-phosphate dehydratase activity
namespace: molecular_function
alt_id: GO:0043809
def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O." [EC:4.2.1.109, RHEA:15549]
synonym: "1-PMT-ribulose dehydratase activity" RELATED [EC:4.2.1.109]
synonym: "5-methylthioribulose-1-phosphate 4-dehydratase activity" EXACT [MetaCyc:R145-RXN]
synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT []
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109]
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT []
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT []
xref: EC:4.2.1.109
xref: KEGG_REACTION:R07392
xref: MetaCyc:R145-RXN
xref: Reactome:R-HSA-1237140 "Dehydration of methylthio-ribulose-P"
xref: RHEA:15549
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0046571
name: obsolete aspartate-2-keto-4-methylthiobutyrate transaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN]
comment: This term was obsoleted because it represents a specific substrate of branched-chain-amino-acid transaminase activity ; GO:0004084.
is_obsolete: true
replaced_by: GO:0004084

[Term]
id: GO:0046572
name: versicolorin B synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: versiconal = versicolorin B + H2O." [MetaCyc:RXN-9494, PMID:8784203]
xref: EC:4.2.1.143
xref: MetaCyc:RXN-9494
xref: RHEA:33859
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0046573
name: lactonohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0046574
name: glycuronidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176]
synonym: "glucuronyl hydrolase activity" EXACT []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046575
name: rhamnogalacturonan acetylesterase activity
namespace: molecular_function
def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485]
is_a: GO:0008126 ! acetylesterase activity

[Term]
id: GO:0046576
name: rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076]
synonym: "rhamnogalacturonase B activity" EXACT [PMID:8587995]
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0046577
name: long-chain-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20]
synonym: "fatty alcohol oxidase activity" EXACT []
synonym: "fatty alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.20]
synonym: "long-chain fatty acid oxidase activity" RELATED [EC:1.1.3.20]
synonym: "long-chain fatty alcohol oxidase activity" EXACT []
synonym: "long-chain-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.20]
xref: EC:1.1.3.20
xref: MetaCyc:RXN-4444
xref: RHEA:22756
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0046578
name: regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046579
name: positive regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
synonym: "activation of Ras protein signal transduction" NARROW []
synonym: "stimulation of Ras protein signal transduction" NARROW []
synonym: "up regulation of Ras protein signal transduction" EXACT []
synonym: "up-regulation of Ras protein signal transduction" EXACT []
synonym: "upregulation of Ras protein signal transduction" EXACT []
is_a: GO:0046578 ! regulation of Ras protein signal transduction
is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction
relationship: positively_regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046580
name: negative regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
synonym: "down regulation of Ras protein signal transduction" EXACT []
synonym: "down-regulation of Ras protein signal transduction" EXACT []
synonym: "downregulation of Ras protein signal transduction" EXACT []
synonym: "inhibition of Ras protein signal transduction" NARROW []
is_a: GO:0046578 ! regulation of Ras protein signal transduction
is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction
relationship: negatively_regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046581
name: intercellular canaliculus
namespace: cellular_component
def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0046583
name: monoatomic cation efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "cation efflux permease activity" EXACT []
synonym: "cation efflux transmembrane transporter activity" BROAD []
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0046584
name: enniatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732]
synonym: "enniatin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0050761 ! depsipeptide metabolic process
is_a: GO:0072338 ! lactam metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:0046585
name: enniatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732]
synonym: "enniatin anabolism" EXACT []
synonym: "enniatin biosynthesis" EXACT []
synonym: "enniatin formation" EXACT []
synonym: "enniatin synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0046584 ! enniatin metabolic process
is_a: GO:0050763 ! depsipeptide biosynthetic process
is_a: GO:0072339 ! lactam biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0046586
name: regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:ai]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

[Term]
id: GO:0046587
name: positive regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai]
synonym: "activation of calcium-dependent cell-cell adhesion" NARROW []
synonym: "stimulation of calcium-dependent cell-cell adhesion" NARROW []
synonym: "up regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "up-regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "upregulation of calcium-dependent cell-cell adhesion" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion
relationship: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

[Term]
id: GO:0046588
name: negative regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai]
synonym: "down regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "down-regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "downregulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "inhibition of calcium-dependent cell-cell adhesion" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion
relationship: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

[Term]
id: GO:0046589
name: ribonuclease T1 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.24]
synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:4.6.1.24]
synonym: "binase activity" RELATED []
synonym: "guanyl-specific RNase activity" RELATED []
synonym: "guanyloribonuclease activity" RELATED [EC:4.6.1.24]
synonym: "ribonuclease C2" RELATED []
synonym: "ribonuclease Ch" RELATED [EC:4.6.1.24]
synonym: "ribonuclease F1" EXACT []
synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" RELATED [EC:4.6.1.24]
synonym: "ribonuclease N1" RELATED [EC:4.6.1.24]
synonym: "ribonuclease N3" RELATED []
synonym: "ribonuclease PP1" RELATED []
synonym: "ribonuclease SA" RELATED []
synonym: "ribonuclease U1" RELATED []
synonym: "RNase F1" RELATED []
synonym: "RNase G" RELATED []
synonym: "RNase N1 activity" RELATED [EC:4.6.1.24]
synonym: "RNase N2 activity" RELATED [EC:4.6.1.24]
synonym: "RNase Sa" RELATED []
synonym: "RNase T1" RELATED [EC:4.6.1.24]
synonym: "RNase T1 activity" EXACT []
xref: EC:4.6.1.24
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0046590
name: obsolete embryonic leg morphogenesis
namespace: biological_process
def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "embryonic leg morphogenesis" EXACT []
is_obsolete: true
consider: GO:0030326
consider: GO:0035116

[Term]
id: GO:0046591
name: obsolete embryonic leg joint morphogenesis
namespace: biological_process
def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:bf, ISBN:0582227089, PMID:12051824]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "embryonic leg joint morphogenesis" EXACT []
is_obsolete: true
consider: GO:0036023

[Term]
id: GO:0046592
name: polyamine oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidative degradation or interconversion of polyamines." [PMID:1567380]
synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW []
synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW []
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0046593
name: mandelonitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10]
synonym: "(R)-oxynitrilase activity" RELATED [EC:4.1.2.10]
synonym: "D-alpha-hydroxynitrile lyase activity" RELATED [EC:4.1.2.10]
synonym: "D-oxynitrilase activity" RELATED [EC:4.1.2.10]
synonym: "hydroxynitrile lyase activity" BROAD []
synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" RELATED [EC:4.1.2.10]
synonym: "mandelonitrile benzaldehyde-lyase activity" RELATED [EC:4.1.2.10]
xref: EC:4.1.2.10
xref: MetaCyc:MANDELONITRILE-LYASE-RXN
xref: RHEA:18313
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0046594
name: maintenance of pole plasm mRNA location
namespace: biological_process
alt_id: GO:0048122
def: "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb]
synonym: "maintenance of oocyte pole plasm mRNA localization" EXACT []
synonym: "maintenance of pole plasm mRNA localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051237 ! maintenance of RNA location
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0046595
name: establishment of pole plasm mRNA localization
namespace: biological_process
alt_id: GO:0048121
def: "Any process that results in the directed movement of mRNA to the oocyte pole plasm." [GOC:bf]
synonym: "establishment of oocyte pole plasm mRNA localization" EXACT []
synonym: "establishment of pole plasm mRNA localisation" EXACT [GOC:mah]
is_a: GO:0051236 ! establishment of RNA localization
is_a: GO:0051649 ! establishment of localization in cell
relationship: part_of GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0046596
name: regulation of viral entry into host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the viral entry into the host cell." [GOC:jl]
synonym: "regulation of viral penetration into host cell" EXACT []
synonym: "viral escort protein" RELATED [GOC:bm]
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:1903900 ! regulation of viral life cycle
relationship: regulates GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0046597
name: blocking of symbiont entry into host cell
namespace: biological_process
def: "A process in which a host inhibits or disrupts the entry of a symbiont into a host cell." [PMID:23544079]
synonym: "negative regulation of symbiont entry into host cell" RELATED []
synonym: "negative regulation of viral entry into host cell" NARROW []
synonym: "negative regulation of viral penetration into host cell" EXACT []
synonym: "prevention of symbiont entry into host cell" EXACT []
is_a: GO:0035821 ! modulation of process of another organism
is_a: GO:0045087 ! innate immune response
is_a: GO:0051851 ! modulation by host of symbiont process

[Term]
id: GO:0046598
name: positive regulation of viral entry into host cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell." [GOC:jl]
synonym: "positive regulation of viral penetration into host cell" EXACT []
is_a: GO:0046596 ! regulation of viral entry into host cell
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
is_a: GO:1903902 ! positive regulation of viral life cycle
relationship: positively_regulates GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0046599
name: regulation of centriole replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]
is_a: GO:0010824 ! regulation of centrosome duplication
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046600
name: negative regulation of centriole replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication." [GOC:ai]
synonym: "down regulation of centriole replication" EXACT []
synonym: "down-regulation of centriole replication" EXACT []
synonym: "downregulation of centriole replication" EXACT []
synonym: "inhibition of centriole replication" NARROW []
is_a: GO:0010826 ! negative regulation of centrosome duplication
is_a: GO:0046599 ! regulation of centriole replication
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046601
name: positive regulation of centriole replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]
synonym: "activation of centriole replication" NARROW []
synonym: "stimulation of centriole replication" NARROW []
synonym: "up regulation of centriole replication" EXACT []
synonym: "up-regulation of centriole replication" EXACT []
synonym: "upregulation of centriole replication" EXACT []
is_a: GO:0046599 ! regulation of centriole replication
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046602
name: regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046603
name: negative regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation." [GOC:ai]
synonym: "down regulation of mitotic centrosome separation" EXACT []
synonym: "down-regulation of mitotic centrosome separation" EXACT []
synonym: "downregulation of mitotic centrosome separation" EXACT []
synonym: "inhibition of mitotic centrosome separation" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0046602 ! regulation of mitotic centrosome separation
relationship: negatively_regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046604
name: positive regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai]
synonym: "activation of mitotic centrosome separation" NARROW []
synonym: "stimulation of mitotic centrosome separation" NARROW []
synonym: "up regulation of mitotic centrosome separation" EXACT []
synonym: "up-regulation of mitotic centrosome separation" EXACT []
synonym: "upregulation of mitotic centrosome separation" EXACT []
is_a: GO:0046602 ! regulation of mitotic centrosome separation
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046605
name: regulation of centrosome cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032886 ! regulation of microtubule-based process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046606
name: negative regulation of centrosome cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai]
synonym: "down regulation of centrosome cycle" EXACT []
synonym: "down-regulation of centrosome cycle" EXACT []
synonym: "downregulation of centrosome cycle" EXACT []
synonym: "inhibition of centrosome cycle" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0046605 ! regulation of centrosome cycle
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046607
name: positive regulation of centrosome cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai]
synonym: "activation of centrosome cycle" NARROW []
synonym: "stimulation of centrosome cycle" NARROW []
synonym: "up regulation of centrosome cycle" EXACT []
synonym: "up-regulation of centrosome cycle" EXACT []
synonym: "upregulation of centrosome cycle" EXACT []
is_a: GO:0046605 ! regulation of centrosome cycle
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046608
name: carotenoid isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677]
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0046609
name: obsolete voltage-gated sulfate antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + solute(in) = solute(in) + sulfate(out), by a channel in a cell membrane whose opening is governed by the membrane potential." [GOC:mah]
comment: This term was obsoleted because there is no evidence that this function exists.
synonym: "prestin" NARROW []
synonym: "voltage gated sulfate antiporter activity" EXACT []
synonym: "voltage-dependent sulfate antiporter activity" EXACT []
synonym: "voltage-sensitive sulfate antiporter activity" EXACT []
synonym: "voltage-sensitive sulphate antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0046610
name: lysosomal proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah]
synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0000220 ! vacuolar proton-transporting V-type ATPase, V0 domain
relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex

[Term]
id: GO:0046611
name: lysosomal proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]
synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT []
synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD []
is_a: GO:0016471 ! vacuolar proton-transporting V-type ATPase complex
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0046612
name: lysosomal proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah]
synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0000221 ! vacuolar proton-transporting V-type ATPase, V1 domain
relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex

[Term]
id: GO:0046615
name: obsolete re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449]
comment: This term was made obsolete because there is no evidence that this process is unique to Saccharomyces.
synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000321

[Term]
id: GO:0046617
name: obsolete nucleolar size increase (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "nucleolar size increase (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0046618
name: xenobiotic export from cell
namespace: biological_process
def: "The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators, GOC:krc]
synonym: "drug export" RELATED []
synonym: "xenobiotic export" RELATED []
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0140352 ! export from cell

[Term]
id: GO:0046619
name: lens placode formation involved in camera-type eye formation
namespace: biological_process
def: "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
synonym: "optic placode formation in camera-type eye" EXACT []
synonym: "optic placode formation involved in camera-style eye" EXACT []
synonym: "optic placode formation involved in camera-type eye formation" RELATED []
is_a: GO:0001743 ! lens placode formation
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0046620
name: regulation of organ growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0035265 ! organ growth

[Term]
id: GO:0046621
name: negative regulation of organ growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046622
name: positive regulation of organ growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046623
name: sphingolipid floppase activity
namespace: molecular_function
def: "Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [GOC:ai, PMID:12034738]
synonym: "sphingolipid flippase activity" EXACT []
synonym: "sphingolipid floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
synonym: "sphingolipid-translocating ATPase activity" RELATED []
is_a: GO:0046624 ! sphingolipid transporter activity
is_a: GO:0140328 ! floppase activity

[Term]
id: GO:0046624
name: sphingolipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732]
xref: Reactome:R-HSA-9695890 "SPNS2,MFSD2B transport S1P from cytosol to extracellular region"
xref: Reactome:R-HSA-9843721 "ABCC1,ABCG2 transport C18-S1P to extracellular region"
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0046625
name: sphingolipid binding
namespace: molecular_function
def: "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0046626
name: regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "regulation of insulin receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046627
name: negative regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "down regulation of insulin receptor signaling pathway" EXACT []
synonym: "down-regulation of insulin receptor signaling pathway" EXACT []
synonym: "downregulation of insulin receptor signaling pathway" EXACT []
synonym: "inhibition of insulin receptor signaling pathway" NARROW []
synonym: "negative regulation of insulin receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0046626 ! regulation of insulin receptor signaling pathway
is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus
relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046628
name: positive regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "activation of insulin receptor signaling pathway" NARROW []
synonym: "positive regulation of insulin receptor signalling pathway" EXACT []
synonym: "stimulation of insulin receptor signaling pathway" NARROW []
synonym: "up regulation of insulin receptor signaling pathway" EXACT []
synonym: "up-regulation of insulin receptor signaling pathway" EXACT []
synonym: "upregulation of insulin receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0046626 ! regulation of insulin receptor signaling pathway
is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus
relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046629
name: gamma-delta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add]
synonym: "gamma-delta T lymphocyte activation" EXACT []
synonym: "gamma-delta T-cell activation" EXACT []
synonym: "gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046630
name: gamma-delta T cell proliferation
namespace: biological_process
def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai]
synonym: "gamma-delta T lymphocyte proliferation" EXACT []
synonym: "gamma-delta T-cell proliferation" EXACT []
synonym: "gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046631
name: alpha-beta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add]
synonym: "alpha-beta T lymphocyte activation" EXACT []
synonym: "alpha-beta T-cell activation" EXACT []
synonym: "alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046632
name: alpha-beta T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex." [CL:0000789, GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta T cell development" RELATED [GOC:add]
synonym: "alpha-beta T lymphocyte differentiation" EXACT []
synonym: "alpha-beta T-cell differentiation" EXACT []
synonym: "alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046633
name: alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai]
synonym: "alpha-beta T lymphocyte proliferation" EXACT []
synonym: "alpha-beta T-cell proliferation" EXACT []
synonym: "alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046634
name: regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "regulation of alpha-beta T-cell activation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046635
name: positive regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "activation of alpha-beta T cell activation" NARROW []
synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "positive regulation of alpha-beta T-cell activation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT []
synonym: "stimulation of alpha-beta T cell activation" NARROW []
synonym: "up regulation of alpha-beta T cell activation" EXACT []
synonym: "up-regulation of alpha-beta T cell activation" EXACT []
synonym: "upregulation of alpha-beta T cell activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046636
name: negative regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "down regulation of alpha-beta T cell activation" EXACT []
synonym: "down-regulation of alpha-beta T cell activation" EXACT []
synonym: "downregulation of alpha-beta T cell activation" EXACT []
synonym: "inhibition of alpha-beta T cell activation" NARROW []
synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "negative regulation of alpha-beta T-cell activation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046637
name: regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of alpha-beta T cell development" RELATED [GOC:add]
synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046638
name: positive regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of alpha-beta T cell differentiation" NARROW []
synonym: "positive regulation of alpha-beta T cell development" RELATED [GOC:add]
synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of alpha-beta T cell differentiation" NARROW []
synonym: "up regulation of alpha-beta T cell differentiation" EXACT []
synonym: "up-regulation of alpha-beta T cell differentiation" EXACT []
synonym: "upregulation of alpha-beta T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: positively_regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046639
name: negative regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of alpha-beta T cell differentiation" EXACT []
synonym: "down-regulation of alpha-beta T cell differentiation" EXACT []
synonym: "downregulation of alpha-beta T cell differentiation" EXACT []
synonym: "inhibition of alpha-beta T cell differentiation" NARROW []
synonym: "negative regulation of alpha-beta T cell development" RELATED [GOC:add]
synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046640
name: regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046641
name: positive regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "activation of alpha-beta T cell proliferation" NARROW []
synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT []
synonym: "stimulation of alpha-beta T cell proliferation" NARROW []
synonym: "up regulation of alpha-beta T cell proliferation" EXACT []
synonym: "up-regulation of alpha-beta T cell proliferation" EXACT []
synonym: "upregulation of alpha-beta T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
relationship: positively_regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046642
name: negative regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "down regulation of alpha-beta T cell proliferation" EXACT []
synonym: "down-regulation of alpha-beta T cell proliferation" EXACT []
synonym: "downregulation of alpha-beta T cell proliferation" EXACT []
synonym: "inhibition of alpha-beta T cell proliferation" NARROW []
synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
relationship: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046643
name: regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "regulation of gamma-delta T-cell activation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046644
name: negative regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "down regulation of gamma-delta T cell activation" EXACT []
synonym: "down-regulation of gamma-delta T cell activation" EXACT []
synonym: "downregulation of gamma-delta T cell activation" EXACT []
synonym: "inhibition of gamma-delta T cell activation" NARROW []
synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "negative regulation of gamma-delta T-cell activation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046645
name: positive regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "activation of gamma-delta T cell activation" NARROW []
synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "positive regulation of gamma-delta T-cell activation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT []
synonym: "stimulation of gamma-delta T cell activation" NARROW []
synonym: "up regulation of gamma-delta T cell activation" EXACT []
synonym: "up-regulation of gamma-delta T cell activation" EXACT []
synonym: "upregulation of gamma-delta T cell activation" EXACT []
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046646
name: regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
relationship: regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046647
name: negative regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "down regulation of gamma-delta T cell proliferation" EXACT []
synonym: "down-regulation of gamma-delta T cell proliferation" EXACT []
synonym: "downregulation of gamma-delta T cell proliferation" EXACT []
synonym: "inhibition of gamma-delta T cell proliferation" NARROW []
synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation
relationship: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046648
name: positive regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "activation of gamma-delta T cell proliferation" NARROW []
synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT []
synonym: "stimulation of gamma-delta T cell proliferation" NARROW []
synonym: "up regulation of gamma-delta T cell proliferation" EXACT []
synonym: "up-regulation of gamma-delta T cell proliferation" EXACT []
synonym: "upregulation of gamma-delta T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation
relationship: positively_regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046649
name: lymphocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0046651
name: lymphocyte proliferation
namespace: biological_process
def: "The expansion of a lymphocyte population by cell division." [GOC:ai]
is_a: GO:0032943 ! mononuclear cell proliferation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0046653
name: tetrahydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]
synonym: "tetrahydrofolate metabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process

[Term]
id: GO:0046654
name: tetrahydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]
synonym: "tetrahydrofolate anabolism" EXACT []
synonym: "tetrahydrofolate biosynthesis" EXACT []
synonym: "tetrahydrofolate formation" EXACT []
synonym: "tetrahydrofolate synthesis" EXACT []
xref: MetaCyc:FOLSYN-PWY
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0046653 ! tetrahydrofolate metabolic process

[Term]
id: GO:0046655
name: folic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732]
synonym: "folate metabolic process" EXACT []
synonym: "folate metabolism" EXACT []
synonym: "folic acid metabolism" EXACT []
synonym: "vitamin B9 metabolic process" EXACT []
synonym: "vitamin B9 metabolism" EXACT []
synonym: "vitamin M metabolic process" EXACT []
synonym: "vitamin M metabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046656
name: folic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid." [GOC:ai]
synonym: "folate biosynthesis" EXACT []
synonym: "folate biosynthetic process" EXACT []
synonym: "folic acid anabolism" EXACT []
synonym: "folic acid biosynthesis" EXACT []
synonym: "folic acid formation" EXACT []
synonym: "folic acid synthesis" EXACT []
synonym: "vitamin B9 biosynthesis" EXACT []
synonym: "vitamin B9 biosynthetic process" EXACT []
synonym: "vitamin M biosynthesis" EXACT []
synonym: "vitamin M biosynthetic process" EXACT []
xref: Wikipedia:Folic_acid
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046655 ! folic acid metabolic process

[Term]
id: GO:0046657
name: folic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid." [GOC:ai]
synonym: "folate catabolic process" EXACT []
synonym: "folate catabolism" EXACT []
synonym: "folic acid breakdown" EXACT []
synonym: "folic acid catabolism" EXACT []
synonym: "folic acid degradation" EXACT []
synonym: "vitamin B9 catabolic process" EXACT []
synonym: "vitamin B9 catabolism" EXACT []
synonym: "vitamin M catabolic process" EXACT []
synonym: "vitamin M catabolism" EXACT []
is_a: GO:0009397 ! folic acid-containing compound catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046655 ! folic acid metabolic process

[Term]
id: GO:0046658
name: obsolete anchored component of plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "anchored to plasma membrane" NARROW []
synonym: "plasma membrane, GPI-anchored" NARROW []
is_obsolete: true
replaced_by: GO:0005886

[Term]
id: GO:0046659
name: digestive hormone activity
namespace: molecular_function
def: "The action characteristic of a hormone that takes part in the digestion process." [GOC:ai]
synonym: "secretin" NARROW []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0046660
name: female sex differentiation
namespace: biological_process
def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0046661
name: male sex differentiation
namespace: biological_process
def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0046662
name: regulation of egg-laying behavior
namespace: biological_process
alt_id: GO:0048042
def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:dph, GOC:tb, PMID:11932766]
synonym: "regulation of oviposition" EXACT []
synonym: "regulation of post-mating oviposition" NARROW []
is_a: GO:0050795 ! regulation of behavior
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0018991 ! egg-laying behavior

[Term]
id: GO:0046663
name: dorsal closure, leading edge cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138]
is_a: GO:0035026 ! leading edge cell differentiation
relationship: part_of GO:0007392 ! initiation of dorsal closure

[Term]
id: GO:0046664
name: dorsal closure, amnioserosa morphology change
namespace: biological_process
def: "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0046665
name: amnioserosa maintenance
namespace: biological_process
def: "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf]
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0046666
name: retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the developing retina." [GOC:bf]
synonym: "programmed cell death, retina cells" EXACT []
synonym: "programmed cell death, retinal cells" EXACT []
synonym: "retina cell programmed cell death" EXACT []
synonym: "retina programmed cell death" EXACT []
synonym: "retinal programmed cell death" EXACT []
is_a: GO:0010623 ! programmed cell death involved in cell development
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0046667
name: compound eye retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
is_a: GO:0046666 ! retinal cell programmed cell death
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0046668
name: regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046669
name: regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046670
name: positive regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "activation of retinal programmed cell death" NARROW []
synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb]
synonym: "stimulation of retinal programmed cell death" NARROW []
synonym: "up regulation of retinal programmed cell death" EXACT []
synonym: "up-regulation of retinal programmed cell death" EXACT []
synonym: "upregulation of retinal programmed cell death" EXACT []
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046671
name: negative regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "down regulation of retinal programmed cell death" EXACT []
synonym: "down-regulation of retinal programmed cell death" EXACT []
synonym: "downregulation of retinal programmed cell death" EXACT []
synonym: "inhibition of retinal programmed cell death" NARROW []
synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046672
name: positive regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "activation of retinal cell programmed cell death" BROAD []
synonym: "positive regulation of retinal cell programmed cell death" BROAD []
synonym: "stimulation of retinal cell programmed cell death" BROAD []
synonym: "up regulation of retinal cell programmed cell death" BROAD []
synonym: "up-regulation of retinal cell programmed cell death" BROAD []
synonym: "upregulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death
relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046673
name: negative regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "down regulation of retinal cell programmed cell death" BROAD []
synonym: "down-regulation of retinal cell programmed cell death" BROAD []
synonym: "downregulation of retinal cell programmed cell death" BROAD []
synonym: "inhibition of retinal cell programmed cell death" BROAD []
synonym: "negative regulation of retina cell programmed cell death" BROAD []
synonym: "negative regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death
relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046676
name: negative regulation of insulin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
synonym: "down regulation of insulin secretion" EXACT []
synonym: "down-regulation of insulin secretion" EXACT []
synonym: "downregulation of insulin secretion" EXACT []
synonym: "inhibition of insulin secretion" NARROW []
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0046677
name: response to antibiotic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef]
subset: goslim_chembl
synonym: "antibiotic susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0046678
name: response to bacteriocin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [ISBN:0721662544]
synonym: "bacteriocin susceptibility/resistance" RELATED []
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0046679
name: response to streptomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators]
synonym: "streptomycin susceptibility/resistance" RELATED []
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1903416 ! response to glycoside

[Term]
id: GO:0046680
name: response to DDT
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
synonym: "DDT resistance" RELATED []
synonym: "DDT susceptibility/resistance" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046681
name: response to carbamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544]
synonym: "carbamate resistance" RELATED []
synonym: "carbamate susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0046682
name: response to cyclodiene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring." [ISBN:0877797099]
synonym: "cyclodiene resistance" RELATED []
synonym: "cyclodiene susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046683
name: response to organophosphorus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
synonym: "organophosphorus resistance" RELATED []
synonym: "organophosphorus susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0046684
name: response to pyrethroid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544]
synonym: "pyrethroid resistance" RELATED []
synonym: "pyrethroid susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046685
name: response to arsenic-containing substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544]
synonym: "arsenate sensitivity/resistance" RELATED []
synonym: "response to arsenic" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0046686
name: response to cadmium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai]
synonym: "cadmium sensitivity/resistance" RELATED []
synonym: "response to cadmium" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046687
name: response to chromate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [ISBN:0721662544]
synonym: "chromate sensitivity/resistance" RELATED []
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0046688
name: response to copper ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai]
synonym: "copper sensitivity/resistance" RELATED []
synonym: "response to copper" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046689
name: response to mercury ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai]
synonym: "mercuric sensitivity/resistance" RELATED []
synonym: "response to mercuric ion" NARROW [GOC:mah]
synonym: "response to mercury" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046690
name: response to tellurium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:ai]
synonym: "response to tellurium" EXACT []
synonym: "tellurium sensitivity/resistance" RELATED []
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0046691
name: intracellular canaliculus
namespace: cellular_component
def: "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [GOC:mah, ISBN:0721662544, PMID:10700045]
synonym: "canalicular membrane" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0046692
name: sperm competition
namespace: biological_process
def: "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514]
xref: Wikipedia:Sperm_competition
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0046693
name: sperm storage
namespace: biological_process
def: "The retention of sperm by a female following mating." [PMID:10885514]
synonym: "retention of sperm" EXACT []
synonym: "sequestering of sperm" EXACT []
synonym: "sequestration of sperm" EXACT []
synonym: "sperm retention" EXACT []
synonym: "sperm sequestering" EXACT []
synonym: "sperm sequestration" EXACT []
synonym: "storage of sperm" EXACT []
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0046694
name: sperm incapacitation
namespace: biological_process
def: "The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males." [PMID:10440373]
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0046695
name: SLIK (SAGA-like) complex
namespace: cellular_component
def: "A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction." [PMID:33864814]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "SAGA (alt) complex" EXACT []
synonym: "SALSA complex" EXACT []
synonym: "SLIK/SALSA complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0046696
name: lipopolysaccharide receptor complex
namespace: cellular_component
def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens." [PMID:11706042, PMID:9665271]
comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of.
synonym: "LPS receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0046697
name: decidualization
namespace: biological_process
def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [ISBN:0721662544, PMID:11133685]
synonym: "decidual cell reaction" EXACT []
xref: Wikipedia:Decidualization
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0001893 ! maternal placenta development

[Term]
id: GO:0046700
name: obsolete heterocycle catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009056

[Term]
id: GO:0046701
name: insecticide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai]
synonym: "insecticide breakdown" EXACT []
synonym: "insecticide catabolism" EXACT []
synonym: "insecticide degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046702
name: galactoside 6-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479]
is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity

[Term]
id: GO:0046703
name: natural killer cell lectin-like receptor binding
namespace: molecular_function
def: "Binding to a lectin-like natural killer cell receptor." [GOC:ai]
synonym: "KLRC4 receptor binding" NARROW []
synonym: "NK cell lectin-like receptor binding" EXACT []
synonym: "NKG2D receptor binding" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0046704
name: CDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate." [GOC:ai]
synonym: "CDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046705
name: CDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai]
synonym: "CDP anabolism" EXACT []
synonym: "CDP biosynthesis" EXACT []
synonym: "CDP formation" EXACT []
synonym: "CDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046704 ! CDP metabolic process

[Term]
id: GO:0046706
name: CDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate." [GOC:ai]
synonym: "CDP breakdown" EXACT []
synonym: "CDP catabolism" EXACT []
synonym: "CDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046704 ! CDP metabolic process

[Term]
id: GO:0046707
name: IDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate." [GOC:ai]
synonym: "IDP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046708
name: IDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate." [GOC:ai]
synonym: "IDP anabolism" EXACT []
synonym: "IDP biosynthesis" EXACT []
synonym: "IDP formation" EXACT []
synonym: "IDP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0046709
name: IDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate." [GOC:ai]
synonym: "IDP breakdown" EXACT []
synonym: "IDP catabolism" EXACT []
synonym: "IDP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0046710
name: GDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate." [GOC:ai]
synonym: "GDP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046711
name: GDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate." [GOC:ai]
synonym: "GDP anabolism" EXACT []
synonym: "GDP biosynthesis" EXACT []
synonym: "GDP formation" EXACT []
synonym: "GDP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046710 ! GDP metabolic process

[Term]
id: GO:0046712
name: GDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate." [GOC:ai]
synonym: "GDP breakdown" EXACT []
synonym: "GDP catabolism" EXACT []
synonym: "GDP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046710 ! GDP metabolic process

[Term]
id: GO:0046713
name: borate transport
namespace: biological_process
def: "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [PMID:21710975]
synonym: "boron transport" RELATED []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0046714
name: borate binding
namespace: molecular_function
def: "Binding to borate, the anion (BO3)3-." [GOC:curators]
synonym: "boron binding" RELATED []
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0046715
name: active borate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0080138
def: "Enables the transport of borate across a membrane against the concentration gradient." [PMID:12447444]
synonym: "borate transmembrane transporter activity" BROAD []
synonym: "borate uptake transmembrane transporter activity" RELATED []
synonym: "boron transmembrane transporter activity" RELATED []
synonym: "boron uptake transmembrane transporter activity" RELATED []
synonym: "efflux-type borate transporter" NARROW []
synonym: "efflux-type boron transporter" RELATED []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0046716
name: muscle cell cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb]
synonym: "muscle homeostasis" RELATED [GOC:dph]
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0046717
name: acid secretion
namespace: biological_process
def: "The controlled release of acid by a cell or a tissue." [GOC:ai]
is_a: GO:0046903 ! secretion

[Term]
id: GO:0046718
name: symbiont entry into host cell
namespace: biological_process
alt_id: GO:0019063
def: "The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell." [GOC:jl]
comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
subset: goslim_metagenomics
synonym: "entry of virus into host cell" NARROW []
synonym: "phage translocation" NARROW []
synonym: "viral entry into host cell" NARROW []
synonym: "viral penetration" NARROW []
synonym: "virion penetration" NARROW []
synonym: "virion penetration into host cell" NARROW []
synonym: "virus entry into host cell" NARROW []
xref: VZ:936 "Virus entry"
is_a: GO:0044409 ! symbiont entry into host
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0046719
name: regulation by virus of viral protein levels in host cell
namespace: biological_process
def: "Any virus-mediated process that modulates the levels of viral proteins in a cell." [GOC:ai]
synonym: "regulation of viral protein levels" EXACT []
is_a: GO:0050792 ! regulation of viral process
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0046720
name: citric acid secretion
namespace: biological_process
def: "The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue." [GOC:ai]
synonym: "citrate secretion" EXACT []
is_a: GO:0015746 ! citrate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046721
name: formic acid secretion
namespace: biological_process
def: "The controlled release of formic acid, HCOOH, by a cell or a tissue." [GOC:ai]
synonym: "formate secretion" EXACT []
is_a: GO:0015724 ! formate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046722
name: lactic acid secretion
namespace: biological_process
def: "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue." [GOC:ai]
synonym: "lactate secretion" EXACT []
is_a: GO:0035879 ! plasma membrane lactate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046723
name: malic acid secretion
namespace: biological_process
def: "The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue." [GOC:ai]
synonym: "hydroxysuccinic acid secretion" EXACT []
synonym: "malate secretion" EXACT []
is_a: GO:0015743 ! malate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046724
name: oxalic acid secretion
namespace: biological_process
def: "The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue." [GOC:ai]
synonym: "oxalate secretion" EXACT []
is_a: GO:0019532 ! oxalate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046725
name: negative regulation by virus of viral protein levels in host cell
namespace: biological_process
def: "Any process where the infecting virus reduces the levels of viral proteins in a cell." [GOC:ai]
synonym: "down regulation of viral protein levels in host cell" EXACT []
synonym: "down-regulation of viral protein levels in host cell" EXACT []
synonym: "downregulation of viral protein levels in host cell" EXACT []
synonym: "inhibition of viral protein levels in host cell" NARROW []
synonym: "negative regulation of viral protein levels" EXACT []
is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell
is_a: GO:0048525 ! negative regulation of viral process

[Term]
id: GO:0046726
name: positive regulation by virus of viral protein levels in host cell
namespace: biological_process
def: "Any process where the infecting virus increases the levels of viral proteins in a cell." [GOC:ai]
synonym: "activation of viral protein levels in host cell" NARROW []
synonym: "positive regulation of viral protein levels" EXACT []
synonym: "stimulation of viral protein levels in host cell" NARROW []
synonym: "up regulation of viral protein levels in host cell" EXACT []
synonym: "up-regulation of viral protein levels in host cell" EXACT []
synonym: "upregulation of viral protein levels in host cell" EXACT []
is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell
is_a: GO:0048524 ! positive regulation of viral process

[Term]
id: GO:0046727
name: capsomere
namespace: cellular_component
def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732]
synonym: "capsomer" EXACT []
xref: Wikipedia:Capsomere
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046729
name: viral procapsid
namespace: cellular_component
def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272]
is_a: GO:0044423 ! virion component

[Term]
id: GO:0046730
name: obsolete induction by virus of host immune response
namespace: biological_process
alt_id: GO:0046731
alt_id: GO:0046732
alt_id: GO:0046733
alt_id: GO:0046734
alt_id: GO:0046735
def: "OBSOLETE. The induction by a virus of an immune response in the host organism." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this is different from the normal host immunity.
synonym: "activation of host immune response by virus" EXACT []
synonym: "active induction of host immune response by virus" RELATED []
synonym: "active viral induction of host immune response" RELATED []
synonym: "passive activation of host immune response by virus" NARROW []
synonym: "passive induction of cell-mediated immune response in host by virus" NARROW []
synonym: "passive induction of host cell-mediated immune response by virus" NARROW []
synonym: "passive induction of host humoral immune response by virus" NARROW []
synonym: "passive induction of host immune response by virus" NARROW []
synonym: "passive induction of host innate immune response by virus" NARROW []
synonym: "passive induction of humoral immune response in host by virus" NARROW []
synonym: "passive induction of innate immune response in host by virus" NARROW []
synonym: "passive viral activation of cell-mediated immune response in host" NARROW []
synonym: "passive viral activation of humoral immune response in host" NARROW []
synonym: "passive viral activation of innate immune response in host" NARROW []
synonym: "passive viral induction of cell-mediated immune response in host" NARROW []
synonym: "passive viral induction of host immune response" NARROW []
synonym: "passive viral induction of humoral immune response in host" NARROW []
synonym: "passive viral induction of innate immune response in host" NARROW []
is_obsolete: true
replaced_by: GO:0006955

[Term]
id: GO:0046736
name: obsolete induction of humoral immune response in host by virus
namespace: biological_process
def: "OBSOLETE. The intentional, virally-encoded stimulation of a host humoral defense response to viral infection." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this is different from the normal host immunity.
synonym: "active induction of humoral immune response in host by virus" RELATED []
synonym: "active viral induction of humoral immune response in host" EXACT []
is_obsolete: true
consider: GO:0061844

[Term]
id: GO:0046737
name: obsolete induction of cell-mediated immune response in host by virus
namespace: biological_process
def: "OBSOLETE. The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this is different from the normal host immunity.
synonym: "active induction of cell-mediated immune response in host by virus" RELATED []
synonym: "active viral induction of cell-mediated immune response in host" EXACT []
is_obsolete: true
consider: GO:0001788

[Term]
id: GO:0046738
name: obsolete induction of innate immune response in host by virus
namespace: biological_process
def: "OBSOLETE. The intentional, virally-encoded stimulation of an innate host defense response to viral infection." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this is different from the normal host immunity.
synonym: "active induction of innate immune response in host by virus" RELATED []
synonym: "active viral induction of innate immune response in host" EXACT []
is_obsolete: true
consider: GO:0140374

[Term]
id: GO:0046739
name: transport of virus in multicellular host
namespace: biological_process
def: "The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs)." [GOC:bf, GOC:jl, ISBN:0781718325]
synonym: "spread of virus in multicellular host" RELATED [GOC:bf, GOC:jl]
synonym: "spread of virus within multicellular host" EXACT []
synonym: "viral spread within multicellular host" EXACT []
is_a: GO:0044001 ! migration in host
is_a: GO:0046794 ! transport of virus

[Term]
id: GO:0046740
name: transport of virus in host, cell to cell
namespace: biological_process
def: "The transport of a virus between adjacent cells in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325]
synonym: "cell to cell spread of virus within host" EXACT []
synonym: "intercellular virus transport" EXACT [GOC:bf, GOC:jl]
synonym: "spread of virus in host, cell to cell" RELATED [GOC:bf, GOC:jl]
synonym: "spread of virus within host, cell to cell" EXACT []
synonym: "viral spread within host, cell to cell" EXACT []
xref: VZ:1018
is_a: GO:0046739 ! transport of virus in multicellular host

[Term]
id: GO:0046741
name: transport of virus in host, tissue to tissue
namespace: biological_process
def: "The transport of a virus between tissues in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325]
synonym: "spread of virus in host, tissue to tissue" RELATED [GOC:bf, GOC:jl]
synonym: "spread of virus within host, tissue to tissue" EXACT []
synonym: "tissue to tissue spread of virus within host" EXACT []
synonym: "viral spread within host, tissue to tissue" EXACT []
is_a: GO:0046739 ! transport of virus in multicellular host

[Term]
id: GO:0046745
name: viral capsid secondary envelopment
namespace: biological_process
alt_id: GO:0046746
alt_id: GO:0046747
alt_id: GO:0046748
alt_id: GO:0046768
alt_id: GO:0046769
alt_id: GO:0046770
def: "The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope." [ISBN:0072370319, ISBN:0781718325, PMID:11533156]
synonym: "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "ER membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "Golgi membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "inner nuclear membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "nuclear membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "outer nuclear membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "plasma membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "viral budding from ER membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from ER membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from Golgi membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from Golgi membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from inner nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from inner nuclear membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from nuclear membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from outer nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from outer nuclear membrane during viral capsid re-envelopment" EXACT []
synonym: "viral budding from plasma membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from plasma membrane during viral capsid re-envelopment" RELATED []
synonym: "viral capsid re-envelopment" RELATED [GOC:bf, GOC:jl]
synonym: "virus budding from ER membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from ER membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from Golgi membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from Golgi membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from inner nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from outer nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from outer nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from plasma membrane during viral capsid re-envelopment" RELATED [GOC:tb]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0046752
name: obsolete viral capsid precursor transport to host cell nucleus
namespace: biological_process
def: "OBSOLETE. Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid." [ISBN:0781718325]
comment: This term was obsoleted because it encompasses the target of the transport process.
synonym: "establishment and maintenance of viral capsid precursor localization in nucleus" BROAD []
synonym: "localization of viral capsid precursors in nucleus" BROAD []
synonym: "nuclear localization of viral capsid precursors" BROAD []
synonym: "viral capsid precursor localisation in host cell nucleus" BROAD [GOC:mah]
synonym: "viral capsid precursor localization in host cell nucleus" BROAD []
synonym: "viral capsid precursor localization to host cell nucleus" BROAD [GOC:bf, GOC:jl]
is_obsolete: true

[Term]
id: GO:0046753
name: non-lytic viral release
namespace: biological_process
def: "The exit of a viral particle from a host cell that does not involve cell lysis." [GOC:bf, GOC:jl, ISBN:0072370319]
is_a: GO:0019076 ! viral release from host cell

[Term]
id: GO:0046754
name: viral exocytosis
namespace: biological_process
def: "The exit of a fully formed virion particles from the host cell by exocytosis via a host vesicle." [ISBN:0072370319, PMID:33157038]
synonym: "viral egress by exocytosis" EXACT []
is_a: GO:0046753 ! non-lytic viral release

[Term]
id: GO:0046755
name: viral budding
namespace: biological_process
alt_id: GO:0046744
def: "A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space." [ISBN:0781718325, VZ:1947]
synonym: "viral capsid envelopment" RELATED []
synonym: "virion budding" NARROW []
synonym: "virus budding" RELATED []
xref: VZ:1947 "Viral budding"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0046757
name: obsolete lytic virus budding from ER membrane
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic endoplasmic reticulum membrane viral budding" EXACT []
synonym: "lytic ER membrane viral budding" EXACT []
synonym: "lytic viral budding from ER membrane" EXACT []
synonym: "lytic virus budding from ER membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0046758
name: obsolete lytic virus budding from Golgi membrane
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic Golgi membrane viral budding" EXACT []
synonym: "lytic viral budding from Golgi membrane" EXACT []
synonym: "lytic virus budding from Golgi membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0046759
name: obsolete lytic virus budding from plasma membrane
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic plasma membrane viral budding" EXACT []
synonym: "lytic viral budding from plasma membrane" EXACT []
synonym: "lytic virus budding from plasma membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0046760
name: viral budding from Golgi membrane
namespace: biological_process
alt_id: GO:0046750
alt_id: GO:0046763
def: "A viral budding that starts with formation of a membrane curvature in the host Golgi membrane." [GOC:bf, ISBN:0072370319, VZ:1947]
synonym: "Golgi membrane viral budding" EXACT []
synonym: "Golgi membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from Golgi membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from Golgi membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from Golgi membrane" EXACT []
synonym: "virus budding from Golgi membrane by viral capsid envelopment" RELATED []
synonym: "virus budding from Golgi membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046755 ! viral budding

[Term]
id: GO:0046761
name: viral budding from plasma membrane
namespace: biological_process
alt_id: GO:0046766
alt_id: GO:0046767
def: "A viral budding that starts with formation of a curvature in the host plasma membrane around which the virion particle assembles." [GOC:bf, ISBN:0072370319, PMID:9394621, VZ:1947]
synonym: "plasma membrane viral budding" EXACT []
synonym: "plasma membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from plasma membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from plasma membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from plasma membrane" EXACT []
synonym: "virus budding from plasma membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from plasma membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046753 ! non-lytic viral release
is_a: GO:0046755 ! viral budding

[Term]
id: GO:0046762
name: viral budding from endoplasmic reticulum membrane
namespace: biological_process
alt_id: GO:0046751
alt_id: GO:0046764
def: "A viral budding that starts with formation of a membrane curvature in the host ER membrane." [GOC:bf, GOC:jl, ISBN:0072370319, VZ:1947]
synonym: "endoplasmic reticulum membrane viral budding" EXACT []
synonym: "endoplasmic reticulum membrane viral budding during viral capsid envelopment" RELATED []
synonym: "ER membrane viral budding" EXACT []
synonym: "ER membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from ER membrane" EXACT []
synonym: "viral budding from ER membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from ER membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from ER membrane" EXACT []
synonym: "virus budding from ER membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from ER membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046755 ! viral budding

[Term]
id: GO:0046765
name: viral budding from nuclear membrane
namespace: biological_process
alt_id: GO:0046749
def: "A viral budding that starts with formation of a membrane curvature in the host nuclear membrane." [GOC:bf, ISBN:0072370319]
synonym: "nuclear membrane viral budding" EXACT []
synonym: "nuclear membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from nuclear membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from nuclear membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from nuclear membrane" EXACT []
synonym: "virus budding from nuclear membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from nuclear membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046755 ! viral budding
relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress

[Term]
id: GO:0046771
name: viral budding from inner nuclear membrane
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system into the perinuclear space, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "inner nuclear membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from inner nuclear membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from inner nuclear membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from inner nuclear membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from inner nuclear membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046765 ! viral budding from nuclear membrane

[Term]
id: GO:0046772
name: viral budding from outer nuclear membrane
namespace: biological_process
def: "The envelopment of a virus, in which the naked capsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "outer nuclear membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from outer nuclear membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from outer nuclear membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from outer nuclear membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046765 ! viral budding from nuclear membrane

[Term]
id: GO:0046773
name: symbiont-mediated suppression of host translation termination
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts translation termination of host mRNAs. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0781718325]
synonym: "suppression by virus of host translation termination" NARROW []
synonym: "viral inhibition of termination of host cell protein biosynthesis" NARROW []
synonym: "viral inhibition of termination of host cell protein biosynthetic process" NARROW []
synonym: "viral suppression of termination by host of host cell protein biosynthesis" NARROW []
synonym: "viral suppression of termination by host of host cell protein biosynthetic process" NARROW []
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0046774
name: obsolete suppression by virus of host intracellular interferon activity
namespace: biological_process
def: "OBSOLETE. Any viral process that results in the inhibition of interferon activity within the host cell." [PMID:10859382]
comment: This term was obsoleted because it was overlapping with symbiont-mediated suppression of host interferon-mediated signaling pathway ; GO:0140886.
synonym: "negative regulation by virus of intracellular interferon activity" EXACT []
synonym: "suppression by virus of intracellular interferon activity in host" EXACT []
is_obsolete: true
consider: GO:0140886

[Term]
id: GO:0046775
name: obsolete suppression by virus of host cytokine production
namespace: biological_process
def: "OBSOLETE. Any viral process that results in the inhibition of host cell cytokine production." [PMID:10859382]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "negative regulation by virus of host cytokine production" EXACT []
is_obsolete: true

[Term]
id: GO:0046776
name: symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
alt_id: GO:0039591
def: "A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, some viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response." [GOC:add, GOC:bf, PMID:10227971, PMID:10859382, PMID:9175839]
synonym: "inhibition of host MHC class I molecule presentation by virus" NARROW []
synonym: "negative regulation by virus of MHC class I cell surface presentation" NARROW []
synonym: "suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "suppression by virus of host MHC class I cell surface presentation" NARROW [GOC:add]
synonym: "suppression by virus of host tapasin activity" NARROW []
synonym: "suppression by virus of MHC class I cell surface presentation in host" NARROW []
is_a: GO:0039588 ! symbiont-mediated suppression of host antigen processing and presentation

[Term]
id: GO:0046777
name: protein autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid autophosphorylation" EXACT [GOC:bf]
xref: Wikipedia:Autophosphorylation
is_a: GO:0006468 ! protein phosphorylation

[Term]
id: GO:0046778
name: obsolete modification by virus of host mRNA processing
namespace: biological_process
def: "OBSOLETE. Any viral process that interferes with the processing of mRNA in the host cell." [ISBN:0781718325]
comment: This term was obsoleted because it is an unnecessary grouing class.
synonym: "viral perturbation of host mRNA processing" EXACT []
is_obsolete: true
consider: GO:0039524

[Term]
id: GO:0046779
name: obsolete suppression by virus of expression of host genes with introns
namespace: biological_process
def: "OBSOLETE. Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed." [PMID:11598019]
comment: The reason for obsoleting this term is that it is too specific.
synonym: "negative regulation by virus of expression of host genes with introns" EXACT []
synonym: "viral inhibition of expression of host genes with introns" EXACT []
is_obsolete: true

[Term]
id: GO:0046780
name: symbiont-mediated suppression of host mRNA splicing
namespace: biological_process
alt_id: GO:0046781
def: "A process in which a symbiont inhibits or disrupts the splicing of host mRNA, thus interfering with normal host protein production. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12660167, PMID:19729513]
synonym: "negative regulation by virus of host mRNA splicing" NARROW []
synonym: "suppression by virus of host mRNA splicing" NARROW []
synonym: "suppression by virus of host splicing factor activity" EXACT []
synonym: "viral dispersion of host splicing factors" NARROW []
synonym: "viral inhibition of host mRNA splicing" NARROW []
is_a: GO:0039524 ! symbiont-mediated suppression of host mRNA processing

[Term]
id: GO:0046782
name: regulation of viral transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transcription of the viral genome." [GOC:ai]
is_a: GO:0050792 ! regulation of viral process
relationship: regulates GO:0019083 ! viral transcription

[Term]
id: GO:0046783
name: obsolete modification by virus of host polysomes
namespace: biological_process
def: "OBSOLETE. Any viral process that interferes with and inhibits the assembly and function of polysomes." [PMID:10438802]
comment: This term was obsoleted because it represents the same process as symbiont-mediated inactivation of host ribosome ; GO:0141130.
synonym: "viral perturbation of polysomes" EXACT []
is_obsolete: true
replaced_by: GO:0141130

[Term]
id: GO:0046784
name: viral mRNA export from host cell nucleus
namespace: biological_process
def: "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation." [PMID:11598019]
synonym: "intronless viral mRNA export from host cell nucleus" EXACT []
synonym: "intronless viral mRNA export from host nucleus" RELATED []
synonym: "intronless viral mRNA export out of nucleus" EXACT []
synonym: "intronless viral mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "intronless viral mRNA-nucleus export" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019080 ! viral gene expression

[Term]
id: GO:0046785
name: microtubule polymerization
namespace: biological_process
def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]
synonym: "microtubule assembly" EXACT []
synonym: "microtubule formation" RELATED []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0046786
name: viral replication complex formation and maintenance
namespace: biological_process
def: "The process of organizing and assembling viral replication proteins in preparation for viral replication." [ISBN:0781718325]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019079 ! viral genome replication

[Term]
id: GO:0046787
name: viral DNA repair
namespace: biological_process
def: "The process of restoring viral DNA after damage or errors in replication." [ISBN:0781718325]
is_a: GO:0006281 ! DNA repair
relationship: part_of GO:0016032 ! viral process

[Term]
id: GO:0046789
name: host cell surface receptor binding
namespace: molecular_function
def: "Binding to a receptor on the host cell surface." [GOC:ai, PMID:11511370]
subset: goslim_chembl
synonym: "cell surface antigen activity, host-interacting" RELATED []
synonym: "cell surface receptor ligand" RELATED []
is_a: GO:0046812 ! host cell surface binding

[Term]
id: GO:0046790
name: virion binding
namespace: molecular_function
def: "Binding to a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046791
name: obsolete suppression by virus of host complement neutralization
namespace: biological_process
def: "OBSOLETE. Any viral process that results in the inhibition of complement neutralization of the host cell." [PMID:10587354]
comment: This term was made obsolete because the meaning of the term is unclear. It most likely refers to inhibiting the process by which a virus particle is neutralized by the host cell in a complement-dependent manner.
synonym: "negative regulation by virus of host complement neutralization" EXACT []
synonym: "suppression by virus of host complement neutralization" EXACT []
is_obsolete: true

[Term]
id: GO:0046792
name: obsolete suppression by virus of host cell cycle arrest
namespace: biological_process
def: "OBSOLETE. Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "negative regulation by virus of cell cycle arrest" EXACT []
synonym: "viral inhibition of cell cycle arrest" EXACT []
is_obsolete: true
consider: GO:0044071

[Term]
id: GO:0046793
name: obsolete induction by virus of phosphorylation of host RNA polymerase II
namespace: biological_process
def: "OBSOLETE. Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II." [PMID:7637000]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
synonym: "induction by virus of modification of host RNA polymerase II" BROAD [GOC:bf, GOC:jl]
synonym: "virus-induced modification of host RNA polymerase II" EXACT []
is_obsolete: true

[Term]
id: GO:0046794
name: transport of virus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, into, out of, or within a host cell." [GOC:ai]
subset: goslim_pir
synonym: "viral transport" EXACT [GOC:bf, GOC:jl]
synonym: "virion transport" NARROW [GOC:bf, GOC:jl]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0046797
name: viral procapsid maturation
namespace: biological_process
def: "The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure." [GOC:bf, PMID:10627558, PMID:19204733]
synonym: "capsid maturation" EXACT []
synonym: "viral capsid maturation" EXACT [PMID:19204733]
synonym: "virion maturation" BROAD [UniProtKB-KW:KW-0917]
xref: UniProtKB-KW:KW-1273
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0019069 ! viral capsid assembly
relationship: part_of GO:0019075 ! virus maturation

[Term]
id: GO:0046798
name: viral portal complex
namespace: cellular_component
def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046799
name: obsolete recruitment of helicase-primase complex to DNA lesions
namespace: biological_process
def: "OBSOLETE. The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair." [ISBN:0781718325]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046800
name: obsolete enhancement of virulence
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease." [PMID:10587354]
comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism.
synonym: "enhancement of virulence" EXACT []
is_obsolete: true

[Term]
id: GO:0046802
name: exit of virus from host cell nucleus by nuclear egress
namespace: biological_process
alt_id: GO:0039676
def: "The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm." [PMID:21494278, PMID:22858153, PMID:9601512, PMID:9765421, VZ:1952]
synonym: "capsid egress" EXACT [VZ:2177]
synonym: "egress of viral procapsid from host cell nucleus" RELATED []
synonym: "nuclear egress" EXACT [PMID:22858153]
synonym: "nuclear egress of viral procapsid" EXACT []
xref: VZ:1952 "Nuclear egress"
is_a: GO:0039674 ! exit of virus from host cell nucleus

[Term]
id: GO:0046803
name: obsolete reduction of virulence
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease." [PMID:10982346]
comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism.
synonym: "reduction of virulence" EXACT []
is_obsolete: true

[Term]
id: GO:0046804
name: obsolete peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide
namespace: biological_process
def: "OBSOLETE. The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine." [RESID:AA0330]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
synonym: "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide" EXACT []
xref: RESID:AA0330
is_obsolete: true

[Term]
id: GO:0046805
name: obsolete protein-heme linkage via 1'-L-histidine
namespace: biological_process
def: "OBSOLETE. The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine)." [RESID:AA0329]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein-haem linkage via 1'-L-histidine" EXACT []
is_obsolete: true

[Term]
id: GO:0046806
name: viral scaffold
namespace: cellular_component
def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046807
name: viral scaffold assembly and maintenance
namespace: biological_process
def: "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed." [ISBN:0072370319]
comment: See also the cellular component term 'viral scaffold ; GO:0046806'.
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019069 ! viral capsid assembly

[Term]
id: GO:0046808
name: obsolete assemblon
namespace: cellular_component
def: "OBSOLETE. Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489]
comment: This term was obsoleted because it does not correspond to a real cellular component, but to a site of immunoreactivity.
is_obsolete: true

[Term]
id: GO:0046809
name: replication compartment
namespace: cellular_component
def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108, VZ:1951]
synonym: "RC" EXACT [VZ:1951]
is_a: GO:0039715 ! nuclear viral factory

[Term]
id: GO:0046810
name: host cell extracellular matrix binding
namespace: molecular_function
def: "Binding to the extracellular matrix of a host cell." [PMID:7996163]
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0046811
name: histone deacetylase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0035033 ! histone deacetylase regulator activity

[Term]
id: GO:0046812
name: host cell surface binding
namespace: molecular_function
def: "Binding to the surface of a host cell." [GOC:ai]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0046813
name: receptor-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface." [ISBN:0879694971]
synonym: "virion attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl]
is_a: GO:0019062 ! virion attachment to host cell

[Term]
id: GO:0046814
name: coreceptor-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface." [ISBN:0879694971]
synonym: "virion attachment, binding of host cell surface coreceptor" EXACT [GOC:bf, GOC:jl]
is_a: GO:0019062 ! virion attachment to host cell

[Term]
id: GO:0046815
name: obsolete genome retention in viral capsid
namespace: biological_process
def: "OBSOLETE. Any process in which the viral genome is retained within the capsid during genome cleavage and packaging." [PMID:9696839]
comment: This term was obsoleted because it represents an assay.
is_obsolete: true
consider: GO:0019072

[Term]
id: GO:0046816
name: virion transport vesicle
namespace: cellular_component
def: "A vesicle used to transport the partial or complete virion between cellular compartments." [GOC:vesicles, PMID:7933124]
is_a: GO:0097708 ! intracellular vesicle

[Term]
id: GO:0046817
name: chemokine receptor antagonist activity
namespace: molecular_function
def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325]
is_a: GO:0048019 ! receptor antagonist activity

[Term]
id: GO:0046818
name: dense nuclear body
namespace: cellular_component
def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0046819
name: protein secretion by the type V secretion system
namespace: biological_process
def: "The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway." [GOC:pamgo_curators]
synonym: "autotransporter system" EXACT []
synonym: "protein secretion by the autotransporter system" EXACT []
synonym: "protein secretion by the type V protein secretion system" EXACT []
synonym: "type V protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0098776 ! protein transport across the cell outer membrane

[Term]
id: GO:0046820
name: 4-amino-4-deoxychorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [EC:2.6.1.85, RHEA:11672]
comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
synonym: "ADC synthase activity" RELATED [EC:2.6.1.85]
synonym: "aminodeoxychorismate synthase activity" RELATED []
synonym: "chorismate:L-glutamine amido-ligase activity" RELATED [EC:2.6.1.85]
synonym: "p-aminobenzoate synthetase" RELATED []
synonym: "PabB activity" RELATED [EC:2.6.1.85]
synonym: "para-aminobenzoic acid (PABA) synthase" RELATED []
synonym: "para-aminobenzoic acid synthase activity" RELATED []
xref: EC:2.6.1.85
xref: KEGG_REACTION:R01716
xref: MetaCyc:PABASYN-RXN
xref: RHEA:11672
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0046821
name: extrachromosomal DNA
namespace: cellular_component
def: "DNA structures that are not part of a chromosome." [GOC:ai]
xref: Wikipedia:Extrachromosomal_DNA
is_a: GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0046822
name: regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046823
name: negative regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf]
synonym: "down regulation of nucleocytoplasmic transport" EXACT []
synonym: "down-regulation of nucleocytoplasmic transport" EXACT []
synonym: "downregulation of nucleocytoplasmic transport" EXACT []
synonym: "inhibition of nucleocytoplasmic transport" NARROW []
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046824
name: positive regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
synonym: "activation of nucleocytoplasmic transport" NARROW []
synonym: "stimulation of nucleocytoplasmic transport" NARROW []
synonym: "up regulation of nucleocytoplasmic transport" EXACT []
synonym: "up-regulation of nucleocytoplasmic transport" EXACT []
synonym: "upregulation of nucleocytoplasmic transport" EXACT []
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046825
name: regulation of protein export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of protein export from cell nucleus" EXACT []
synonym: "regulation of protein export out of nucleus" EXACT []
synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of protein-nucleus export" EXACT []
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046826
name: negative regulation of protein export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of protein export from nucleus" EXACT []
synonym: "down-regulation of protein export from nucleus" EXACT []
synonym: "downregulation of protein export from nucleus" EXACT []
synonym: "inhibition of protein export from nucleus" NARROW []
synonym: "negative regulation of protein export from cell nucleus" EXACT []
synonym: "negative regulation of protein export out of nucleus" EXACT []
synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of protein-nucleus export" EXACT []
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0051457 ! maintenance of protein location in nucleus
is_a: GO:0090317 ! negative regulation of intracellular protein transport
relationship: negatively_regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046827
name: positive regulation of protein export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of protein export from nucleus" NARROW []
synonym: "positive regulation of protein export from cell nucleus" EXACT []
synonym: "positive regulation of protein export out of nucleus" EXACT []
synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of protein-nucleus export" EXACT []
synonym: "stimulation of protein export from nucleus" NARROW []
synonym: "up regulation of protein export from nucleus" EXACT []
synonym: "up-regulation of protein export from nucleus" EXACT []
synonym: "upregulation of protein export from nucleus" EXACT []
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0090316 ! positive regulation of intracellular protein transport
relationship: positively_regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046828
name: regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf]
synonym: "regulation of RNA import into cell nucleus" EXACT []
synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of RNA-nucleus import" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046829
name: negative regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "down regulation of RNA import into nucleus" EXACT []
synonym: "down-regulation of RNA import into nucleus" EXACT []
synonym: "downregulation of RNA import into nucleus" EXACT []
synonym: "inhibition of RNA import into nucleus" NARROW []
synonym: "negative regulation of RNA import into cell nucleus" EXACT []
synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of RNA-nucleus import" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
relationship: negatively_regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046830
name: positive regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "activation of RNA import into nucleus" NARROW []
synonym: "positive regulation of RNA import into cell nucleus" EXACT []
synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of RNA-nucleus import" EXACT []
synonym: "stimulation of RNA import into nucleus" NARROW []
synonym: "up regulation of RNA import into nucleus" EXACT []
synonym: "up-regulation of RNA import into nucleus" EXACT []
synonym: "upregulation of RNA import into nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
relationship: positively_regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046831
name: regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of RNA export from cell nucleus" EXACT []
synonym: "regulation of RNA export out of nucleus" EXACT []
synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of RNA-nucleus export" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046832
name: negative regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of RNA export from nucleus" EXACT []
synonym: "down-regulation of RNA export from nucleus" EXACT []
synonym: "downregulation of RNA export from nucleus" EXACT []
synonym: "inhibition of RNA export from nucleus" NARROW []
synonym: "negative regulation of RNA export from cell nucleus" EXACT []
synonym: "negative regulation of RNA export out of nucleus" EXACT []
synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of RNA-nucleus export" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
relationship: negatively_regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046833
name: positive regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of RNA export from nucleus" NARROW []
synonym: "positive regulation of RNA export from cell nucleus" EXACT []
synonym: "positive regulation of RNA export out of nucleus" EXACT []
synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of RNA-nucleus export" EXACT []
synonym: "stimulation of RNA export from nucleus" NARROW []
synonym: "up regulation of RNA export from nucleus" EXACT []
synonym: "up-regulation of RNA export from nucleus" EXACT []
synonym: "upregulation of RNA export from nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
relationship: positively_regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046834
name: lipid phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]
is_a: GO:0016310 ! phosphorylation
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0046835
name: carbohydrate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0046836
name: glycolipid transport
namespace: biological_process
def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006869 ! lipid transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0046838
name: obsolete phosphorylated carbohydrate dephosphorylation
namespace: biological_process
def: "OBSOLETE. The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it." [ISBN:0198506732]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046839
name: phospholipid dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0046841
name: trisporic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota." [GOC:ai]
synonym: "trisporic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046842
name: trisporic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trisporic acid." [GOC:ai]
synonym: "trisporic acid anabolism" EXACT []
synonym: "trisporic acid biosynthesis" EXACT []
synonym: "trisporic acid formation" EXACT []
synonym: "trisporic acid synthesis" EXACT []
is_a: GO:0046841 ! trisporic acid metabolic process

[Term]
id: GO:0046843
name: dorsal appendage formation
namespace: biological_process
def: "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007306 ! egg chorion assembly

[Term]
id: GO:0046844
name: chorion micropyle formation
namespace: biological_process
def: "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007306 ! egg chorion assembly

[Term]
id: GO:0046845
name: branched duct epithelial cell fate determination, open tracheal system
namespace: biological_process
def: "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581]
synonym: "branch cell fate determination" BROAD []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0046847
name: filopodium assembly
namespace: biological_process
def: "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]
synonym: "filopodia biosynthesis" RELATED []
synonym: "filopodia formation" RELATED []
synonym: "filopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0046848
name: hydroxyapatite binding
namespace: molecular_function
def: "Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin." [PMID:2438276]
synonym: "hydroxylapatite binding" EXACT [GOC:vk]
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0046849
name: bone remodeling
namespace: biological_process
def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators]
synonym: "bone remodelling" EXACT []
xref: Wikipedia:Bone_remodeling
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0046850
name: regulation of bone remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai]
synonym: "regulation of bone remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046851
name: negative regulation of bone remodeling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "down regulation of bone remodeling" EXACT []
synonym: "down-regulation of bone remodeling" EXACT []
synonym: "downregulation of bone remodeling" EXACT []
synonym: "inhibition of bone remodeling" NARROW []
synonym: "negative regulation of bone remodelling" EXACT []
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
relationship: negatively_regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046852
name: positive regulation of bone remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "activation of bone remodeling" NARROW []
synonym: "positive regulation of bone remodelling" EXACT []
synonym: "stimulation of bone remodeling" NARROW []
synonym: "up regulation of bone remodeling" EXACT []
synonym: "up-regulation of bone remodeling" EXACT []
synonym: "upregulation of bone remodeling" EXACT []
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
relationship: positively_regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046853
name: obsolete inositol or phosphatidylinositol phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into inositol or a phosphatidylinositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ISBN:0198506732]
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
synonym: "inositol and derivative phosphorylation" RELATED []
synonym: "inositol or phosphatidylinositol phosphorylation" EXACT []
synonym: "myo-inositol and derivative phosphorylation" RELATED []
synonym: "myo-inositol or phosphatidyl-myo-inositol phosphorylation" NARROW []
is_obsolete: true
consider: GO:0046854

[Term]
id: GO:0046854
name: phosphatidylinositol phosphate biosynthetic process
namespace: biological_process
alt_id: GO:0046837
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]
synonym: "phosphatidylinositol phosphate biosynthesis" EXACT []
synonym: "phosphatidylinositol phosphate phosphorylation" NARROW []
synonym: "phosphatidylinositol phosphorylation" RELATED []
synonym: "phosphoinositide phosphorylation" NARROW []
synonym: "PIP biosynthesis" EXACT []
synonym: "PtdInsP biosynthesis" EXACT []
is_a: GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0046855
name: obsolete inositol phosphate dephosphorylation
namespace: biological_process
def: "OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]
comment: This term was obsoleted because it represents a molecular function.
synonym: "myo-inositol phosphate dephosphorylation" NARROW []
is_obsolete: true
consider: GO:0043647

[Term]
id: GO:0046856
name: phosphatidylinositol dephosphorylation
namespace: biological_process
alt_id: GO:0046840
def: "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
synonym: "phosphatidylinositol phosphate catabolic process" NARROW []
synonym: "phosphatidylinositol phosphate dephosphorylation" NARROW []
synonym: "phosphoinositide dephosphorylation" EXACT []
synonym: "PIP catabolism" NARROW []
synonym: "PtdInsP catabolism" NARROW []
synonym: "PtdInsP dephosphorylation" NARROW []
is_a: GO:0046488 ! phosphatidylinositol metabolic process
is_a: GO:0046839 ! phospholipid dephosphorylation

[Term]
id: GO:0046857
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.7.1.-
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0046858
name: chlorosome
namespace: cellular_component
def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732, PMID:14729689, PMID:15298919]
xref: Wikipedia:Chlorosome
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0046859
name: hydrogenosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai]
synonym: "hydrogenosome membrane" EXACT []
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0042566 ! hydrogenosome

[Term]
id: GO:0046860
name: glycosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glycosome." [GOC:ai]
is_a: GO:0005778 ! peroxisomal membrane
relationship: part_of GO:0020015 ! glycosome

[Term]
id: GO:0046861
name: glyoxysomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai]
synonym: "glyoxysome membrane" EXACT []
is_a: GO:0005778 ! peroxisomal membrane
relationship: part_of GO:0009514 ! glyoxysome

[Term]
id: GO:0046862
name: chromoplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0046863
name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity
namespace: molecular_function
alt_id: GO:0018236
def: "Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515]
comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'.
synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity" EXACT [GOC:dph, GOC:tb]
synonym: "ribulose-bisphosphate carboxylase activase activity" EXACT []
synonym: "rubisco activase activity" EXACT []
synonym: "rubisco activator" EXACT []
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0046864
name: isoprenoid transport
namespace: biological_process
def: "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai]
subset: goslim_pir
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0046865
name: terpenoid transport
namespace: biological_process
def: "The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai]
is_a: GO:0046864 ! isoprenoid transport

[Term]
id: GO:0046866
name: tetraterpenoid transport
namespace: biological_process
def: "The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai]
is_a: GO:0046865 ! terpenoid transport

[Term]
id: GO:0046867
name: carotenoid transport
namespace: biological_process
def: "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai]
is_a: GO:0046866 ! tetraterpenoid transport

[Term]
id: GO:0046868
name: mesosome
namespace: cellular_component
def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [PMID:31921091, PMID:33327493]
xref: Wikipedia:Mesosome
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0046869
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide." [RESID:AA0331]
comment: This term was obsoleted because it represents a molecular function.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide" EXACT []
is_obsolete: true

[Term]
id: GO:0046870
name: cadmium ion binding
namespace: molecular_function
def: "Binding to a cadmium ion (Cd)." [GOC:ai]
synonym: "cadmium binding" EXACT []
synonym: "Cd ion binding" EXACT []
synonym: "copper/cadmium binding" BROAD []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0046871
name: N-acetylgalactosamine binding
namespace: molecular_function
def: "Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [GOC:ai, PMID:18384150]
synonym: "N-acetylgalactosamine lectin" RELATED []
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0046872
name: metal ion binding
namespace: molecular_function
def: "Binding to a metal ion." [GOC:ai]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "heavy metal binding" NARROW []
synonym: "metal binding" EXACT []
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0046873
name: metal ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
synonym: "heavy metal ion porter activity" NARROW []
synonym: "heavy metal ion transporter activity" NARROW []
synonym: "heavy metal ion:hydrogen symporter activity" NARROW []
synonym: "heavy metal-exporting ATPase activity" NARROW []
synonym: "high affinity metal ion uptake transporter activity" NARROW []
synonym: "low affinity metal ion uptake transporter activity" NARROW []
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0046874
name: quinolinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]
synonym: "quinolinate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0046875
name: ephrin receptor binding
namespace: molecular_function
def: "Binding to an ephrin receptor." [GOC:ai]
synonym: "Eph receptor binding" EXACT []
synonym: "ephrin" NARROW []
synonym: "GPI-linked ephrin" NARROW []
synonym: "transmembrane ephrin" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0046876
name: 3,4-didehydroretinal binding
namespace: molecular_function
def: "Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732]
synonym: "blue-sensitive opsin" NARROW []
synonym: "green-sensitive opsin" NARROW []
synonym: "long-wave-sensitive opsin" NARROW []
synonym: "opsin" NARROW []
synonym: "red-sensitive opsin" NARROW []
synonym: "short-wave-sensitive opsin" NARROW []
synonym: "UV-sensitive opsin" NARROW []
synonym: "violet-sensitive opsin" NARROW []
is_a: GO:0005501 ! retinoid binding

[Term]
id: GO:0046877
name: regulation of saliva secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue." [GOC:ai]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0046541 ! saliva secretion

[Term]
id: GO:0046878
name: positive regulation of saliva secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai]
synonym: "activation of saliva secretion" NARROW []
synonym: "stimulation of saliva secretion" NARROW []
synonym: "up regulation of saliva secretion" EXACT []
synonym: "up-regulation of saliva secretion" EXACT []
synonym: "upregulation of saliva secretion" EXACT []
is_a: GO:0046877 ! regulation of saliva secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
relationship: positively_regulates GO:0046541 ! saliva secretion

[Term]
id: GO:0046879
name: hormone secretion
namespace: biological_process
def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732]
is_a: GO:0009914 ! hormone transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0046880
name: regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "regulation of follicle stimulating hormone secretion" EXACT []
synonym: "regulation of FSH secretion" EXACT []
is_a: GO:0032276 ! regulation of gonadotropin secretion
relationship: regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046881
name: positive regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "activation of follicle-stimulating hormone secretion" NARROW []
synonym: "positive regulation of follicle stimulating hormone secretion" EXACT []
synonym: "stimulation of follicle-stimulating hormone secretion" NARROW []
synonym: "up regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "up-regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "upregulation of follicle-stimulating hormone secretion" EXACT []
is_a: GO:0032278 ! positive regulation of gonadotropin secretion
is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion
relationship: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046882
name: negative regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "down regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "down-regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "downregulation of follicle-stimulating hormone secretion" EXACT []
synonym: "inhibition of follicle-stimulating hormone secretion" NARROW []
synonym: "negative regulation of follicle stimulating hormone secretion" EXACT []
is_a: GO:0032277 ! negative regulation of gonadotropin secretion
is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion
relationship: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046883
name: regulation of hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0023051 ! regulation of signaling
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046884
name: follicle-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732]
synonym: "follicle stimulating hormone secretion" EXACT []
synonym: "follitropin secretion" EXACT []
synonym: "FSH secretion" EXACT []
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0046885
name: regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "regulation of hormone anabolism" EXACT []
synonym: "regulation of hormone biosynthesis" EXACT []
synonym: "regulation of hormone formation" EXACT []
synonym: "regulation of hormone synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0046886
name: positive regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "activation of hormone biosynthetic process" NARROW []
synonym: "positive regulation of hormone anabolism" EXACT []
synonym: "positive regulation of hormone biosynthesis" EXACT []
synonym: "positive regulation of hormone formation" EXACT []
synonym: "positive regulation of hormone synthesis" EXACT []
synonym: "stimulation of hormone biosynthetic process" NARROW []
synonym: "up regulation of hormone biosynthetic process" EXACT []
synonym: "up-regulation of hormone biosynthetic process" EXACT []
synonym: "upregulation of hormone biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
relationship: positively_regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0046887
name: positive regulation of hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "activation of hormone secretion" NARROW []
synonym: "stimulation of hormone secretion" NARROW []
synonym: "up regulation of hormone secretion" EXACT []
synonym: "up-regulation of hormone secretion" EXACT []
synonym: "upregulation of hormone secretion" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046888
name: negative regulation of hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "down regulation of hormone secretion" EXACT []
synonym: "down-regulation of hormone secretion" EXACT []
synonym: "downregulation of hormone secretion" EXACT []
synonym: "inhibition of hormone secretion" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046889
name: positive regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "activation of lipid biosynthetic process" NARROW []
synonym: "positive regulation of lipid anabolism" EXACT []
synonym: "positive regulation of lipid biosynthesis" EXACT []
synonym: "positive regulation of lipid formation" EXACT []
synonym: "positive regulation of lipid synthesis" EXACT []
synonym: "positive regulation of lipogenesis" EXACT [GOC:sl]
synonym: "stimulation of lipid biosynthetic process" NARROW []
synonym: "up regulation of lipid biosynthetic process" EXACT []
synonym: "up-regulation of lipid biosynthetic process" EXACT []
synonym: "upregulation of lipid biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: positively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046890
name: regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "regulation of lipid anabolism" EXACT []
synonym: "regulation of lipid biosynthesis" EXACT []
synonym: "regulation of lipid formation" EXACT []
synonym: "regulation of lipid synthesis" EXACT []
synonym: "regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046891
name: obsolete peptidyl-cysteine S-carbamoylation
namespace: biological_process
def: "OBSOLETE. The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine." [RESID:AA0332]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046892
name: obsolete peptidyl-S-carbamoyl-L-cysteine dehydration
namespace: biological_process
def: "OBSOLETE. The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." [PMID:12586941, RESID:AA0333]
comment: This term was obsoleted because it represents a molecular function.
synonym: "formation of peptidyl-S-cyanocysteine" EXACT []
synonym: "formation of peptidyl-serine thiocyanate ester" EXACT []
is_obsolete: true

[Term]
id: GO:0046893
name: obsolete iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase." [RESID:AA0334]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046894
name: obsolete enzyme active site formation via S-amidino-L-cysteine
namespace: biological_process
def: "OBSOLETE. Active site formation via the transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:9148748.
is_obsolete: true
consider: GO:0015068

[Term]
id: GO:0046895
name: obsolete N-terminal peptidyl-isoleucine methylation
namespace: biological_process
def: "OBSOLETE. The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." [RESID:AA0336]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046896
name: obsolete N-terminal peptidyl-leucine methylation
namespace: biological_process
def: "OBSOLETE. The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine." [RESID:AA0337]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046897
name: obsolete N-terminal peptidyl-tyrosine methylation
namespace: biological_process
def: "OBSOLETE. The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine." [RESID:AA0338]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046898
name: response to cycloheximide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:ef, ISBN:0198506732]
synonym: "response to actidione" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0046899
name: nucleoside triphosphate adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10]
synonym: "GTP:AMP phosphotransferase" NARROW []
synonym: "guanosine triphosphate-adenylate kinase" NARROW []
synonym: "isozyme 3 of adenylate kinase activity" RELATED [EC:2.7.4.10]
synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT []
synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT []
synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" RELATED [EC:2.7.4.10]
xref: EC:2.7.4.10
xref: MetaCyc:2.7.4.10-RXN
xref: Reactome:R-HSA-1008248 "Adenylate Kinase 3 is a GTP-AMP phosphotransferase"
xref: RHEA:13749
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0046900
name: tetrahydrofolylpolyglutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]
synonym: "tetrahydrofolyl-[Glu](n) metabolic process" EXACT []
synonym: "tetrahydrofolyl-[Glu](n) metabolism" EXACT []
synonym: "tetrahydrofolylpolyglutamate metabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process

[Term]
id: GO:0046901
name: tetrahydrofolylpolyglutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]
synonym: "folic acid-containing compound polyglutamylation" BROAD [GOC:dhl]
synonym: "tetrahydrofolate polyglutamylation" EXACT [GOC:bf, KEGG:ec00790]
synonym: "tetrahydrofolyl-[Glu](n) biosynthesis" EXACT []
synonym: "tetrahydrofolyl-[Glu](n) biosynthetic process" EXACT []
synonym: "tetrahydrofolylpolyglutamate anabolism" EXACT []
synonym: "tetrahydrofolylpolyglutamate biosynthesis" EXACT []
synonym: "tetrahydrofolylpolyglutamate formation" EXACT []
synonym: "tetrahydrofolylpolyglutamate synthesis" EXACT []
synonym: "THF polyglutamylation" EXACT [GOC:bf, KEGG:ec00790]
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0046900 ! tetrahydrofolylpolyglutamate metabolic process

[Term]
id: GO:0046902
name: regulation of mitochondrial membrane permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf]
synonym: "regulation of mitochondrial envelope permeability" RELATED []
synonym: "regulation of transport across mitochondrial membrane" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0090559 ! regulation of membrane permeability
relationship: part_of GO:0006839 ! mitochondrial transport

[Term]
id: GO:0046903
name: secretion
namespace: biological_process
def: "The controlled release of a substance by a cell or a tissue." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0046904
name: calcium oxalate binding
namespace: molecular_function
def: "Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544]
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0046905
name: 15-cis-phytoene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate." [PMID:12641468, RHEA:34475]
synonym: "geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32]
synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase (15-cis-phytoene-forming) activity" EXACT [EC:2.5.1.32]
synonym: "phytoene synthase activity" EXACT [EC:2.5.1.32]
synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32]
synonym: "PSase activity" EXACT [EC:2.5.1.32]
xref: MetaCyc:RXN-13323
xref: RHEA:34475
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0046906
name: tetrapyrrole binding
namespace: molecular_function
def: "Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732]
subset: goslim_metagenomics
subset: goslim_pir
synonym: "porphyrin binding" NARROW []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0046907
name: intracellular transport
namespace: biological_process
alt_id: GO:1902582
def: "The directed movement of substances within a cell." [GOC:ai]
synonym: "single organism intracellular transport" RELATED [GOC:TermGenie]
synonym: "single-organism intracellular transport" RELATED []
is_a: GO:0006810 ! transport
is_a: GO:0051641 ! cellular localization
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0046908
name: obsolete negative regulation of crystal formation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine." [GOC:ai]
comment: This term was made obsolete because a more appropriate term was created.
synonym: "negative regulation of crystal formation" EXACT []
synonym: "negative regulation of mineralization" RELATED []
is_obsolete: true
replaced_by: GO:0050801

[Term]
id: GO:0046909
name: obsolete intermembrane transport
namespace: biological_process
def: "OBSOLETE. The directed movement of substances between any membrane of a cell, including the plasma membrane and its regions." [GOC:ai, GOC:pr, PMID:10671554]
comment: The reason for obsoletion is that this term was incorrectly named, defined, and placed in the ontology, and thus had been used to annotate two unrelated processes of [intermembrane lipid transfer] and processes related to [vesicular transport]. It was also inappropriately used as the parent term for [protein transport from ciliary membrane to plasma membrane], which has already been moved to an appropriate location as a child of [protein transport within lipid bilayer].
is_obsolete: true
consider: GO:0016192
consider: GO:0120009

[Term]
id: GO:0046910
name: pectinesterase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of pectinesterase." [GOC:ai, PMID:10880981]
comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'.
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0046911
name: metal chelating activity
namespace: molecular_function
def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [ISBN:0198506732, ISBN:0716731363]
synonym: "heavy metal chelation" NARROW []
synonym: "metal chelation" EXACT []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0046912
name: acyltransferase activity, acyl groups converted into alkyl on transfer
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]
synonym: "acyltransferase, acyl groups converted into alkyl on transfer" EXACT []
synonym: "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer" EXACT []
xref: EC:2.3.3.-
is_a: GO:0016746 ! acyltransferase activity

[Term]
id: GO:0046914
name: transition metal ion binding
namespace: molecular_function
def: "Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0046915
name: transition metal ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0046916
name: obsolete intracellular transition metal ion homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of transition metal ions within a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:mah, ISBN:0198506732]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "cellular transition metal ion homeostasis" EXACT []
is_obsolete: true
replaced_by: GO:0030003

[Term]
id: GO:0046917
name: triphosphoribosyl-dephospho-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.4.2.52]
synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" RELATED [EC:2.4.2.52]
synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT []
synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT []
synonym: "CitG activity" RELATED []
xref: EC:2.4.2.52
xref: MetaCyc:2.7.8.25-RXN
xref: RHEA:15117
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0046918
name: obsolete N-terminal peptidyl-glycine N-palmitoylation
namespace: biological_process
def: "OBSOLETE. The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine." [RESID:AA0339]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046919
name: pyruvyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0046920
name: alpha-(1->3)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]
synonym: "alpha(1,3)-fucosyltransferase activity" EXACT []
synonym: "alpha-(1,3)-fucosyltransferase activity" EXACT []
synonym: "alpha-1,3-fucosyltransferase activity" EXACT []
xref: Reactome:R-HSA-9603984 "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX"
xref: Reactome:R-HSA-9605609 "FUT3 transfers Fuc to Type 1 MSGG to form sLeA"
xref: Reactome:R-HSA-9605644 "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA"
xref: Reactome:R-HSA-9605682 "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX"
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0046921
name: alpha-(1->6)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]
synonym: "alpha(1,6)-fucosyltransferase activity" EXACT []
synonym: "alpha-(1,6)-fucosyltransferase activity" EXACT []
synonym: "alpha-1,6-fucosyltransferase activity" EXACT []
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0046922
name: peptide-O-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]
synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.221]
synonym: "GDP-fucose protein O-fucosyltransferase activity" RELATED [EC:2.4.1.221]
synonym: "GDP-fucose:polypeptide fucosyltransferase activity" RELATED [EC:2.4.1.221]
synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" RELATED [EC:2.4.1.221]
xref: EC:2.4.1.221
xref: MetaCyc:2.4.1.221-RXN
xref: Reactome:R-HSA-1912349 "Fucosylation of Pre-NOTCH by POFUT1"
xref: Reactome:R-HSA-5173192 "POFUT2 transfers fucose to TSR domain-containing proteins"
is_a: GO:0008417 ! fucosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0046923
name: ER retention sequence binding
namespace: molecular_function
def: "Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai]
synonym: "endoplasmic reticulum retention sequence binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0046924
name: obsolete peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine
namespace: biological_process
def: "OBSOLETE. The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine." [PMID:12696888, RESID:AA0340]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046925
name: obsolete peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine
namespace: biological_process
def: "OBSOLETE. The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, PMID:36302388, RESID:AA0341]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046926
name: obsolete peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine
namespace: biological_process
def: "OBSOLETE. The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, PMID:36302388, RESID:AA0342]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046927
name: obsolete peptidyl-threonine racemization
namespace: biological_process
def: "OBSOLETE. The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0046928
name: regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046929
name: negative regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai]
synonym: "conotoxin activity" NARROW []
synonym: "down regulation of neurotransmitter secretion" EXACT []
synonym: "down-regulation of neurotransmitter secretion" EXACT []
synonym: "downregulation of neurotransmitter secretion" EXACT []
synonym: "inhibition of neurotransmitter secretion" NARROW []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046930
name: pore complex
namespace: cellular_component
def: "A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732]
synonym: "channel-forming toxin activity" RELATED []
synonym: "pore" EXACT []
synonym: "pore-forming toxin activity" RELATED []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0046931
name: pore complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:jl, GOC:mah]
comment: See also the cellular component term 'pore complex ; GO:0046930'.
synonym: "pore biosynthesis" EXACT []
synonym: "pore complex biogenesis" RELATED [GOC:mah]
synonym: "pore formation" EXACT []
synonym: "pore-forming toxin activity" RELATED []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0046932
name: sodium-transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism." [RHEA:58158]
synonym: "sodium-translocating F-type ATPase activity" EXACT []
synonym: "sodium-transporting two-sector ATPase activity" EXACT []
xref: RHEA:58158
xref: TC:3.A.2.1.2
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0046933
name: proton-transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
def: "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]
synonym: "H+-transporting ATP synthase activity" RELATED [EC:7.1.2.2]
synonym: "hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT []
xref: Reactome:R-HSA-164832 "ATPase synthesizes ATP"
xref: RHEA:57722
xref: TC:3.A.2.1.1
is_a: GO:0015252 ! proton channel activity
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0046934
name: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + H+." [EC:2.7.1.153, RHEA:21292]
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "phosphatidylinositol-4,5-bisphosphate 3-kinase activity" EXACT []
synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153]
xref: EC:2.7.1.153
xref: KEGG_REACTION:R04545
xref: MetaCyc:2.7.1.153-RXN
xref: Reactome:R-HSA-1226014 "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants"
xref: Reactome:R-HSA-1250370 "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers"
xref: Reactome:R-HSA-1250462 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3"
xref: Reactome:R-HSA-1306957 "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR"
xref: Reactome:R-HSA-1306979 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1"
xref: Reactome:R-HSA-1676048 "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane"
xref: Reactome:R-HSA-177939 "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)"
xref: Reactome:R-HSA-1839091 "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-1839107 "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-186800 "PI3K catalyses the phosphorylation of PIP2 to PIP3"
xref: Reactome:R-HSA-198266 "PI3K produces PIP3 and other phosphatidyl inositides"
xref: Reactome:R-HSA-201510 "PI3K synthesizes PIP3 downstream of ALK"
xref: Reactome:R-HSA-202365 "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-2029271 "PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-2076220 "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3"
xref: Reactome:R-HSA-2316434 "PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-2394007 "PI3K gain of function mutants phosphorylate PIP2 to PIP3"
xref: Reactome:R-HSA-2424480 "PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-2730870 "Phosphorylation of PIP2 to PIP3 by PI3K"
xref: Reactome:R-HSA-389158 "CD28 bound PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-392300 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3"
xref: Reactome:R-HSA-437162 "PI3K alpha, beta, gamma convert PIP2 to PIP3"
xref: Reactome:R-HSA-5218819 "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5637801 "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII"
xref: Reactome:R-HSA-5654690 "FGFR1-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5654692 "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5654697 "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5654701 "FGFR2-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5654705 "FGFR3-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5654709 "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5654714 "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5654717 "FGFR4-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5655235 "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5655289 "Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5655290 "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-5655323 "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-8852019 "MET bound PI3K generates PIP3"
xref: Reactome:R-HSA-9021627 "EPOR-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3"
xref: Reactome:R-HSA-9603445 "Activated NTRK3 stimulates PI3K activity"
xref: Reactome:R-HSA-9664664 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3"
xref: Reactome:R-HSA-9664940 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3"
xref: Reactome:R-HSA-9665407 "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3"
xref: Reactome:R-HSA-9672162 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers"
xref: Reactome:R-HSA-9672177 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR"
xref: Reactome:R-HSA-9712084 "PI3K synthesizes PIP3 downstream of ALK mutants"
xref: Reactome:R-HSA-9860816 "Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate"
xref: RHEA:21292
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0046935
name: 1-phosphatidylinositol-3-kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai]
comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'.
synonym: "1-phosphatidylinositol 3-kinase regulator activity" EXACT []
synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW []
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0046936
name: 2'-deoxyadenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyadenosine + H+ + H2O = 2'-deoxyinosine + NH4+." [GOC:ai, RHEA:28190]
synonym: "deoxyadenosine deaminase reaction" EXACT []
xref: MetaCyc:ADDALT-RXN
xref: RHEA:28190
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0046937
name: phytochelatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732]
synonym: "cadystin metabolic process" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "cadystin metabolism" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "phytochelatin metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0046938
name: phytochelatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732]
synonym: "cadystin biosynthetic process" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "phytochelatin anabolism" EXACT []
synonym: "phytochelatin biosynthesis" EXACT []
synonym: "phytochelatin formation" EXACT []
synonym: "phytochelatin synthesis" EXACT []
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046937 ! phytochelatin metabolic process

[Term]
id: GO:0046939
name: obsolete nucleotide phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0046940
name: nucleoside monophosphate phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside." [GOC:ai]
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0046941
name: azetidine-2-carboxylic acid acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200]
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0046942
name: carboxylic acid transport
namespace: biological_process
def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015849 ! organic acid transport

[Term]
id: GO:0046943
name: carboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane"
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0046944
name: protein carbamoylation
namespace: biological_process
def: "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid carbamoylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0046945
name: obsolete N-terminal peptidyl-alanine N-carbamoylation
namespace: biological_process
def: "OBSOLETE. The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine." [RESID:AA0343]
comment: This term was obsoleted because it represents a molecular function.
synonym: "N-terminal peptidyl-alanine N-carbamylation" RELATED []
is_obsolete: true

[Term]
id: GO:0046946
name: hydroxylysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases." [ISBN:0198506732, PubChem_Compound:1029]
synonym: "hydroxylysine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0046947
name: hydroxylysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732]
synonym: "hydroxylysine anabolism" EXACT []
synonym: "hydroxylysine biosynthesis" EXACT []
synonym: "hydroxylysine formation" EXACT []
synonym: "hydroxylysine synthesis" EXACT []
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0046946 ! hydroxylysine metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0046948
name: hydroxylysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732]
synonym: "hydroxylysine breakdown" EXACT []
synonym: "hydroxylysine catabolism" EXACT []
synonym: "hydroxylysine degradation" EXACT []
is_a: GO:0009068 ! aspartate family amino acid catabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0046946 ! hydroxylysine metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0046949
name: fatty-acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]
synonym: "fatty acyl CoA biosynthetic process" EXACT []
synonym: "fatty-acyl-CoA anabolism" EXACT []
synonym: "fatty-acyl-CoA biosynthesis" EXACT []
synonym: "fatty-acyl-CoA formation" EXACT []
synonym: "fatty-acyl-CoA synthesis" EXACT []
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process

[Term]
id: GO:0046950
name: obsolete cellular ketone body metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732]
comment: The reason for obsoletion is that this term is redundant to GO:1902224, ketone body metabolic process
synonym: "cellular ketone body metabolism" EXACT []
is_obsolete: true
replaced_by: GO:1902224

[Term]
id: GO:0046951
name: ketone body biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732]
synonym: "ketone body anabolism" EXACT []
synonym: "ketone body biosynthesis" EXACT []
synonym: "ketone body formation" EXACT []
synonym: "ketone body synthesis" EXACT []
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
is_a: GO:1902224 ! ketone body metabolic process

[Term]
id: GO:0046952
name: ketone body catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732]
synonym: "ketolysis" EXACT [MetaCyc:PWY66-368]
synonym: "ketone body breakdown" EXACT []
synonym: "ketone body catabolism" EXACT []
synonym: "ketone body degradation" EXACT []
synonym: "utilization of ketone bodies" EXACT []
xref: MetaCyc:PWY66-368
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process
is_a: GO:1902224 ! ketone body metabolic process

[Term]
id: GO:0046956
name: positive phototaxis
namespace: biological_process
alt_id: GO:0046954
def: "The directed movement of a cell or organism towards a source of light." [GOC:ai]
synonym: "positive phototactic behavior" EXACT []
synonym: "positive phototactic behaviour" EXACT []
synonym: "positive taxis in response to light" EXACT []
is_a: GO:0042331 ! phototaxis
is_a: GO:0052128 ! positive energy taxis

[Term]
id: GO:0046957
name: negative phototaxis
namespace: biological_process
alt_id: GO:0046955
def: "The directed movement of a cell or organism away from a source of light." [GOC:ai]
synonym: "negative phototactic behavior" EXACT []
synonym: "negative phototactic behaviour" EXACT []
synonym: "negative taxis in response to light" EXACT []
is_a: GO:0042331 ! phototaxis
is_a: GO:0052129 ! negative energy taxis

[Term]
id: GO:0046958
name: nonassociative learning
namespace: biological_process
def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089]
synonym: "unconditional response" EXACT []
is_a: GO:0007612 ! learning

[Term]
id: GO:0046959
name: habituation
namespace: biological_process
def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
xref: Wikipedia:Habituation
is_a: GO:0046958 ! nonassociative learning

[Term]
id: GO:0046960
name: sensitization
namespace: biological_process
def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089]
xref: Wikipedia:Sensitization
is_a: GO:0046958 ! nonassociative learning

[Term]
id: GO:0046961
name: proton-transporting ATPase activity, rotational mechanism
namespace: molecular_function
def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]
synonym: "ATP phosphohydrolase (H+-transporting) activity" NARROW []
synonym: "ATP synthase activity" NARROW [EC:7.1.2.2]
synonym: "chloroplast ATPase activity" NARROW [EC:7.1.2.2]
synonym: "F(0)F(1)-ATPase activity" NARROW [EC:7.1.2.2]
synonym: "F(1)-ATPase activity" NARROW [EC:7.1.2.2]
synonym: "F(o)F(1)-ATPase activity" NARROW [EC:7.1.2.2]
synonym: "F0F1-ATPase" NARROW [EC:7.1.2.2]
synonym: "F1-ATPase" NARROW []
synonym: "FoF1-ATPase" NARROW [EC:7.1.2.2]
synonym: "H+-transporting ATP synthase activity" NARROW [EC:7.1.2.2]
synonym: "H+-transporting ATPase activity" NARROW [EC:7.1.2.2]
synonym: "hydrogen ion translocating A-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating F-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating V-type ATPase activity" NARROW []
synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT []
synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW []
synonym: "mitochondrial ATPase activity" NARROW [EC:7.1.2.2]
xref: RHEA:57721
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism

[Term]
id: GO:0046962
name: sodium-transporting ATPase activity, rotational mechanism
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism." [PMID:30791207, RHEA:58157]
comment: Found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis; similar to EC:7.1.2.2 but pumps Na+ rather than H+. (Source: EC:7.2.2.1)
synonym: "ATP phosphohydrolase (Na+-transporting) activity" RELATED []
synonym: "ATP synthase, sodium ion specific activity" RELATED [EC:7.2.2.1]
synonym: "Na(+)-translocating ATPase activity" BROAD []
synonym: "Na(+)-transporting two-sector ATPase activity" RELATED [EC:7.2.2.1]
synonym: "Na+-translocating ATPase activity" RELATED [EC:7.2.2.1]
synonym: "Na+-translocating F1Fo-ATPase" NARROW []
synonym: "Na+-transporting two-sector ATPase" NARROW [EC:7.2.2.1]
synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT []
synonym: "sodium-translocating F-type ATPase activity" NARROW []
synonym: "sodium-translocating V-type ATPase activity" NARROW []
synonym: "sodium-transporting two-sector ATPase activity" NARROW []
synonym: "vacuolar-type Na+-ATPase" NARROW []
synonym: "vacuolar-type Na+-translocating ATPase" NARROW []
xref: EC:7.2.2.1
xref: RHEA:58157
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism

[Term]
id: GO:0046963
name: 3'-phosphoadenosine 5'-phosphosulfate transport
namespace: biological_process
def: "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
synonym: "3'-phosphoadenosine 5'-phosphosulphate transport" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate transport" EXACT []
synonym: "PAPS transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0046964
name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732]
synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT []
synonym: "PAPS transporter activity" EXACT []
xref: Reactome:R-HSA-741449 "SLC35B2,3 transport cytosolic PAPS to Golgi lumen"
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0046965
name: nuclear retinoid X receptor binding
namespace: molecular_function
def: "Binding to a nuclear retinoid X receptor." [GOC:ai]
synonym: "retinoid X receptor binding" BROAD []
synonym: "RXR binding" EXACT []
is_a: GO:0042974 ! nuclear retinoic acid receptor binding

[Term]
id: GO:0046966
name: nuclear thyroid hormone receptor binding
namespace: molecular_function
def: "Binding to a nuclear thyroid hormone receptor." [GOC:ai]
synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW []
synonym: "thyroid hormone receptor binding" BROAD []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0046967
name: cytosol to endoplasmic reticulum transport
namespace: biological_process
def: "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell." [GOC:ai]
synonym: "cytosol to ER transport" EXACT []
is_a: GO:0046907 ! intracellular transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0046968
name: peptide antigen transport
namespace: biological_process
def: "The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0015833 ! peptide transport
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0046969
name: histone H3K9 deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + NAD+ + H2O = histone H3 L-lysine (position 9) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K9 to NAD, producing nicotinamide." [PMID:28450737]
synonym: "NAD-dependent H3-K9 histone deacetylase activity" EXACT []
synonym: "NAD-dependent histone deacetylase activity (H3-K9 specific)" EXACT []
synonym: "NAD-dependent histone H3K9 deacetylase activity" EXACT []
xref: Reactome:R-HSA-9604829 "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters"
is_a: GO:0017136 ! histone deacetylase activity, NAD-dependent
is_a: GO:0141050 ! histone H3K deacetylase activity

[Term]
id: GO:0046970
name: histone H4K16 deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + NAD+ + H2O = histone H4 L-lysine (position 16) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H4K16 to NAD, producing nicotinamide." [GOC:vw, PMID:28450737]
synonym: "NAD-dependent histone deacetylase activity (H4-K16 specific)" EXACT []
synonym: "NAD-dependent histone H4-K16 deacetylase activity" EXACT []
synonym: "NAD-dependent histone H4K16 deacetylase activity" EXACT []
is_a: GO:0017136 ! histone deacetylase activity, NAD-dependent
is_a: GO:0141051 ! histone H4K deacetylase activity

[Term]
id: GO:0046972
name: histone H4K16 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [PMID:18552846, PMID:19056256]
synonym: "histone acetylase activity (H4-K16 specific)" EXACT []
synonym: "histone acetyltransferase activity (H4-K16 specific)" EXACT []
synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT []
is_a: GO:0010485 ! histone H4 acetyltransferase activity

[Term]
id: GO:0046973
name: obsolete histone lysine N-methyltransferase activity (H3-K24 specific)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein." [GOC:ai]
comment: This term was made obsolete because there is no lysine at position 24 of histone H3.
synonym: "histone lysine N-methyltransferase activity (H3-K24 specific)" EXACT []
is_obsolete: true
consider: GO:0042800

[Term]
id: GO:0046974
name: histone H3K9 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein." [GOC:ai]
synonym: "histone H3K9 methylase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K9 specific)" EXACT []
synonym: "histone methylase activity (H3-K9 specific)" EXACT [GOC:mah]
synonym: "histone methyltransferase activity (H3-K9 specific)" EXACT []
synonym: "histone-H3K9 methyltransferase activity" EXACT []
xref: Reactome:R-HSA-427336 "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9"
xref: Reactome:R-HSA-427527 "eNoSC dimethylates histone H3 at lysine-9"
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0046975
name: histone H3K36 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]
synonym: "histone H3K36 methylase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K36 specific)" EXACT []
synonym: "histone methylase activity (H3-K36 specific)" EXACT [GOC:mah]
synonym: "histone methyltransferase activity (H3-K36 specific)" EXACT []
synonym: "histone-H3K36 methyltransferase activity" EXACT []
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0046976
name: histone H3K27 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein." [GOC:ai]
synonym: "histone H3K27 methylase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K27 specific)" EXACT []
synonym: "histone methylase activity (H3-K27 specific)" EXACT [GOC:mah]
synonym: "histone methylase activity (H3-K56 specific)" EXACT []
synonym: "histone methyltransferase activity (H3-K27 specific)" EXACT []
synonym: "histone-H3K27 methyltransferase activity" EXACT []
xref: Reactome:R-HSA-3240295 "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter"
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0046977
name: TAP binding
namespace: molecular_function
def: "Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046978
name: TAP1 binding
namespace: molecular_function
def: "Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832]
is_a: GO:0046977 ! TAP binding

[Term]
id: GO:0046979
name: TAP2 binding
namespace: molecular_function
def: "Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832]
is_a: GO:0046977 ! TAP binding

[Term]
id: GO:0046980
name: tapasin binding
namespace: molecular_function
def: "Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855]
synonym: "TAP binding protein binding" EXACT [HGNC:11566]
synonym: "TAPBP binding" RELATED [HGNC:11566]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046981
name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651]
synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT []
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0046982
name: protein heterodimerization activity
namespace: molecular_function
def: "Binding to a nonidentical protein to form a heterodimer." [GOC:ai]
subset: goslim_chembl
is_a: GO:0046983 ! protein dimerization activity

[Term]
id: GO:0046983
name: protein dimerization activity
namespace: molecular_function
def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046984
name: regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "regulation of haemoglobin biosynthesis" EXACT []
synonym: "regulation of haemoglobin biosynthetic process" EXACT []
synonym: "regulation of hemoglobin anabolism" EXACT []
synonym: "regulation of hemoglobin biosynthesis" EXACT []
synonym: "regulation of hemoglobin formation" EXACT []
synonym: "regulation of hemoglobin synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046985
name: positive regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "activation of hemoglobin biosynthetic process" NARROW []
synonym: "positive regulation of haemoglobin biosynthesis" EXACT []
synonym: "positive regulation of haemoglobin biosynthetic process" EXACT []
synonym: "positive regulation of hemoglobin anabolism" EXACT []
synonym: "positive regulation of hemoglobin biosynthesis" EXACT []
synonym: "positive regulation of hemoglobin formation" EXACT []
synonym: "positive regulation of hemoglobin synthesis" EXACT []
synonym: "stimulation of hemoglobin biosynthetic process" NARROW []
synonym: "up regulation of hemoglobin biosynthetic process" EXACT []
synonym: "up-regulation of hemoglobin biosynthetic process" EXACT []
synonym: "upregulation of hemoglobin biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046986
name: negative regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "down regulation of hemoglobin biosynthetic process" EXACT []
synonym: "down-regulation of hemoglobin biosynthetic process" EXACT []
synonym: "downregulation of hemoglobin biosynthetic process" EXACT []
synonym: "inhibition of hemoglobin biosynthetic process" NARROW []
synonym: "negative regulation of haemoglobin biosynthesis" EXACT []
synonym: "negative regulation of haemoglobin biosynthetic process" EXACT []
synonym: "negative regulation of hemoglobin anabolism" EXACT []
synonym: "negative regulation of hemoglobin biosynthesis" EXACT []
synonym: "negative regulation of hemoglobin formation" EXACT []
synonym: "negative regulation of hemoglobin synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046987
name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570]
synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT []
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046988
name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046989
name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046990
name: N-hydroxyarylamine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN]
synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" RELATED [EC:2.3.1.118]
synonym: "arylhydroxamate N,O-acetyltransferase activity" RELATED [EC:2.3.1.118]
synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" RELATED [EC:2.3.1.118]
xref: EC:2.3.1.118
xref: MetaCyc:2.3.1.118-RXN
xref: RHEA:20277
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0046992
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai]
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW []
xref: EC:1.21.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0046993
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai]
xref: EC:1.21.3.-
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0046994
name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl]
xref: EC:1.12.5.-
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0046995
name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai]
xref: EC:1.12.98.-
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0046996
name: obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah]
comment: This term was obsoleted because it represented an unnecessary grouping class. All children in EC have been transferred to EC:1.14.19.-.
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated" RELATED []
is_obsolete: true

[Term]
id: GO:0046997
name: oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl]
xref: EC:1.5.8.-
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0046998
name: (S)-usnate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD+ = (S)-usnate + 2 H+ + NADH." [EC:1.1.1.199, RHEA:21876]
synonym: "L-usnic acid dehydrogenase activity" RELATED [EC:1.1.1.199]
synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" RELATED [EC:1.1.1.199]
xref: EC:1.1.1.199
xref: KEGG_REACTION:R07345
xref: MetaCyc:1.1.1.199-RXN
xref: RHEA:21876
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046999
name: obsolete regulation of conjugation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai]
comment: This term was obsoleted because its target (conjugation) was not clearly defined.
is_obsolete: true

[Term]
id: GO:0047000
name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H+ + NADPH." [EC:1.1.1.126, RHEA:15109]
synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" RELATED [EC:1.1.1.126]
synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" RELATED [EC:1.1.1.126]
xref: EC:1.1.1.126
xref: KEGG_REACTION:R01543
xref: MetaCyc:RXN-13040
xref: RHEA:15109
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047001
name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN]
synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" RELATED [EC:1.1.1.127]
synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" RELATED [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" RELATED [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" RELATED [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate dehydrogenase activity" RELATED [EC:1.1.1.127]
xref: EC:1.1.1.127
xref: MetaCyc:1.1.1.127-RXN
xref: RHEA:24232
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047002
name: L-arabinitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinitol + NAD+ = L-ribulose + H+ + NADH." [EC:1.1.1.13, RHEA:21356]
synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT []
xref: EC:1.1.1.13
xref: KEGG_REACTION:R02441
xref: MetaCyc:1.1.1.13-RXN
xref: RHEA:21356
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047003
name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH." [EC:1.1.1.134, RHEA:23648]
synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" RELATED [EC:1.1.1.134]
synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.134]
synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" RELATED [EC:1.1.1.134]
synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" RELATED [EC:1.1.1.134]
xref: EC:1.1.1.134
xref: KEGG_REACTION:R02776
xref: MetaCyc:1.1.1.134-RXN
xref: RHEA:23648
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047004
name: UDP-N-acetylglucosamine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-alpha-D-glucosamine = 3 H+ + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate." [EC:1.1.1.136, RHEA:13325]
synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" RELATED [EC:1.1.1.136]
synonym: "UDP-GLcNAc dehydrogenase activity" RELATED [EC:1.1.1.136]
synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" RELATED [EC:1.1.1.136]
synonym: "UDPacetylglucosamine dehydrogenase activity" RELATED [EC:1.1.1.136]
synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" RELATED [EC:1.1.1.136]
xref: EC:1.1.1.136
xref: KEGG_REACTION:R00421
xref: MetaCyc:1.1.1.136-RXN
xref: RHEA:13325
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047005
name: 16-alpha-hydroxysteroid dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + 16-alpha-hydroxysteroid = NAD(P)H + H+ + 16-oxosteroid." [EC:1.1.1.147]
synonym: "16alpha-hydroxy steroid dehydrogenase activity" RELATED [EC:1.1.1.147]
synonym: "16alpha-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.147]
synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" RELATED [EC:1.1.1.147]
xref: EC:1.1.1.147
xref: MetaCyc:1.1.1.147-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047006
name: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149]
synonym: "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity" EXACT []
synonym: "20alpha-HSD" RELATED [EC:1.1.1.149]
synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149]
synonym: "20alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.149]
synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149]
synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" BROAD [EC:1.1.1.149]
xref: EC:1.1.1.149
xref: MetaCyc:1.1.1.149-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047007
name: pregnan-21-ol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + pregnan-21-ol = H+ + NADH + pregnan-21-al." [RHEA:11448]
synonym: "21-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.50]
synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" BROAD [EC:1.1.1.150]
xref: EC:1.1.1.150
xref: KEGG_REACTION:R03043
xref: MetaCyc:1.1.1.150-RXN
xref: RHEA:11448
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047008
name: pregnan-21-ol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + pregnan-21-ol = H+ + NADPH + pregnan-21-al." [RHEA:23712]
synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxysteroid dehydrogenase (NADP+) activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" BROAD [EC:1.1.1.151]
synonym: "NADP-21-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.151]
xref: EC:1.1.1.151
xref: KEGG_REACTION:R03044
xref: MetaCyc:1.1.1.151-RXN
xref: RHEA:23712
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047009
name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN]
synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" RELATED [EC:1.1.1.152]
synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" RELATED [EC:1.1.1.152]
synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.152]
synonym: "etiocholanolone 3-alpha-dehydrogenase activity" RELATED [EC:1.1.1.152]
synonym: "etiocholanolone 3alpha-dehydrogenase activity" RELATED [EC:1.1.1.152]
xref: EC:1.1.1.152
xref: MetaCyc:1.1.1.152-RXN
xref: RHEA:10356
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047010
name: hydroxycyclohexanecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H+ + NADH." [EC:1.1.1.166, RHEA:10516]
synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" RELATED [EC:1.1.1.166]
synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.166]
synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" RELATED [EC:1.1.1.166]
xref: EC:1.1.1.166
xref: KEGG_REACTION:R05315
xref: MetaCyc:1.1.1.166-RXN
xref: RHEA:10516
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047011
name: 2-dehydropantolactone reductase (A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN]
synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" RELATED [EC:1.1.1.168]
synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" RELATED [EC:1.1.1.168]
synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168]
synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168]
synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168]
xref: EC:1.1.1.168
is_a: GO:0036441 ! 2-dehydropantolactone reductase activity

[Term]
id: GO:0047012
name: obsolete sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [GOC:curators]
comment: This term was obsoleted because it represents the same function as 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity ; GO:0102191.
synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT []
is_obsolete: true
replaced_by: GO:0102175

[Term]
id: GO:0047013
name: cholate 12-alpha dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholate + NADP+ = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + H+ + NADPH." [RHEA:14129]
synonym: "12-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "12alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.176]
synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
xref: EC:1.1.1.176
xref: KEGG_REACTION:R02793
xref: MetaCyc:1.1.1.176-RXN
xref: RHEA:14129
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047014
name: glycerol-3-phosphate 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + H+ + NADPH." [RHEA:19773]
synonym: "glycerin-3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.177]
synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.177]
synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" RELATED [EC:1.1.1.177]
synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.177]
synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.177]
xref: EC:1.1.1.177
xref: KEGG_REACTION:R00845
xref: MetaCyc:1.1.1.177-RXN
xref: RHEA:19773
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047015
name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN]
synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" RELATED [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.178]
xref: EC:1.1.1.178
xref: MetaCyc:1.1.1.178-RXN
xref: RHEA:13281
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047016
name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN]
synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" RELATED [EC:1.1.1.181]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181]
synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" RELATED [EC:1.1.1.181]
synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.181]
xref: EC:1.1.1.181
xref: MetaCyc:1.1.1.181-RXN
xref: RHEA:11896
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047017
name: prostaglandin F synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin D2." [RHEA:10140]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" RELATED [EC:1.1.1.188]
synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" RELATED [EC:1.1.1.188]
synonym: "PGD(2) 11-ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "PGD2 11-ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "PGF synthetase activity" RELATED [EC:1.1.1.188]
synonym: "PGF2alpha synthetase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin 11-keto reductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin 11-ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin D2-ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin F synthetase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-D(2) 11-ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-D(2) 11-reductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-D(2) ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-D2 11-ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-D2 11-reductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-D2 ketoreductase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-F synthase activity" RELATED [EC:1.1.1.188]
synonym: "prostaglandin-F synthetase activity" RELATED [EC:1.1.1.188]
synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" RELATED [EC:1.1.1.188]
synonym: "synthetase, prostaglandin F2alpha" RELATED [EC:1.1.1.188]
xref: EC:1.1.1.188
xref: MetaCyc:1.1.1.188-RXN
xref: RHEA:10140
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047018
name: indole-3-acetaldehyde reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-ethanol + NAD+ = (indol-3-yl)acetaldehyde + H+ + NADH." [EC:1.1.1.190, RHEA:14873]
synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.190]
synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.190]
synonym: "indoleacetaldehyde reductase activity" RELATED [EC:1.1.1.190]
xref: EC:1.1.1.190
xref: KEGG_REACTION:R02679
xref: MetaCyc:1.1.1.190-RXN
xref: RHEA:14873
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0047019
name: indole-3-acetaldehyde reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH." [EC:1.1.1.191, RHEA:17037]
synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.191]
synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.191]
synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.1.1.191]
xref: EC:1.1.1.191
xref: KEGG_REACTION:R02680
xref: MetaCyc:1.1.1.191-RXN
xref: RHEA:17037
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047020
name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" RELATED [EC:1.1.1.196]
synonym: "15-hydroxy PGD2 dehydrogenase activity" RELATED [EC:1.1.1.196]
synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" RELATED [EC:1.1.1.196]
synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.196]
synonym: "dehydrogenase, prostaglandin D2" RELATED [EC:1.1.1.196]
synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" RELATED [EC:1.1.1.196]
synonym: "NADP-PGD2 dehydrogenase activity" RELATED [EC:1.1.1.196]
synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "prostaglandin D2 dehydrogenase activity" RELATED [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP)" RELATED [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" RELATED [EC:1.1.1.196]
xref: EC:1.1.1.196
xref: MetaCyc:1.1.1.196-RXN
xref: RHEA:20744
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047021
name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH." [EC:1.1.1.197, RHEA:11636]
synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" RELATED [EC:1.1.1.197]
synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.197]
xref: EC:1.1.1.197
xref: KEGG_REACTION:R04552
xref: MetaCyc:1.1.1.197-RXN
xref: RHEA:11636
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047022
name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 7-beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+." [RHEA:20233]
synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" RELATED [EC:1.1.1.201]
synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" RELATED [EC:1.1.1.201]
synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.201]
synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.201]
xref: EC:1.1.1.201
xref: MetaCyc:1.1.1.201-RXN
xref: RHEA:20233
xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047023
name: androsterone dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209]
synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209]
synonym: "3(or 17)-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209]
synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209]
synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" BROAD [EC:1.1.1.209]
xref: EC:1.1.1.209
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047024
name: 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-androstane-3-beta,17-beta-diol + NADP+ = 17-beta-hydroxy-5-alpha-androstan-3-one + H+ + NADPH." [RHEA:16297]
synonym: "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210]
synonym: "3-beta-HSD activity" RELATED [EC:1.1.1.210]
synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210]
synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" BROAD [EC:1.1.1.210]
synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.210]
synonym: "5alpha-androstane-3beta,17beta-diol dehydrogenase activity" EXACT []
synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" BROAD [EC:1.1.1.210]
synonym: "progesterone reductase activity" RELATED [EC:1.1.1.210]
xref: EC:1.1.1.210
xref: KEGG_REACTION:R04344
xref: MetaCyc:1.1.1.210-RXN
xref: RHEA:16297
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047025
name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN]
synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.212]
synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT []
synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT []
synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" RELATED [EC:1.1.1.212]
synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" RELATED [EC:1.1.1.212]
xref: EC:1.1.1.212
xref: MetaCyc:1.1.1.212-RXN
xref: RHEA:19913
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047026
name: androsterone dehydrogenase (A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213]
synonym: "3-alpha-hydroxysteroid dehydrogenase (A-specific) activity" BROAD [EC:1.1.1.213]
synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" BROAD [EC:1.1.1.213]
synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" BROAD [EC:1.1.1.213]
xref: EC:1.1.1.213
xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific)
is_a: GO:0047023 ! androsterone dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0047027
name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ = benzyl 2-methyl-3-oxobutanoate + H+ + NADPH." [EC:1.1.1.217, RHEA:16405]
synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" RELATED [EC:1.1.1.217]
synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.217]
xref: EC:1.1.1.217
xref: KEGG_REACTION:R04370
xref: MetaCyc:1.1.1.217-RXN
xref: RHEA:16405
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047028
name: 6-pyruvoyltetrahydropterin 2'-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN]
synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.1.1.220]
synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" RELATED [EC:1.1.1.220]
synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" RELATED [EC:1.1.1.220]
synonym: "6-pyruvoyltetrahydropterin reductase activity" RELATED [EC:1.1.1.220]
synonym: "6PPH4(2'-oxo) reductase activity" RELATED [EC:1.1.1.220]
synonym: "pyruvoyl-tetrahydropterin reductase activity" RELATED [EC:1.1.1.220]
xref: EC:1.1.1.220
xref: MetaCyc:1.1.1.220-RXN
xref: RHEA:11772
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047029
name: (R)-4-hydroxyphenyllactate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate." [RHEA:52692]
synonym: "aromatic 2-oxoacid reductase activity" BROAD []
synonym: "hydroxyphenylpyruvate reductase activity" BROAD []
synonym: "phenylpyruvate reductase activity" RELATED []
xref: MetaCyc:RXN-7632
xref: RHEA:52692
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047030
name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD+ = 4-oxocyclohexanecarboxylate + H+ + NADH." [EC:1.1.1.226, RHEA:17429]
synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" RELATED [EC:1.1.1.226]
synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.226]
xref: EC:1.1.1.226
xref: KEGG_REACTION:R04307
xref: MetaCyc:1.1.1.226-RXN
xref: RHEA:17429
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047031
name: diethyl 2-methyl-3-oxosuccinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + H+ + NADPH." [EC:1.1.1.229, RHEA:21008]
synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.229]
xref: EC:1.1.1.229
xref: KEGG_REACTION:R04387
xref: MetaCyc:1.1.1.229-RXN
xref: RHEA:21008
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047032
name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + H+ + NADPH." [EC:1.1.1.230, RHEA:20816]
synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" RELATED [EC:1.1.1.230]
synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.230]
xref: EC:1.1.1.230
xref: KEGG_REACTION:R04099
xref: MetaCyc:1.1.1.230-RXN
xref: RHEA:20816
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047033
name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H+ + NADPH." [EC:1.1.1.231, RHEA:21420]
synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" RELATED [EC:1.1.1.231]
synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.231]
synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" RELATED [EC:1.1.1.231]
synonym: "PG I2 dehydrogenase activity" RELATED [EC:1.1.1.231]
synonym: "prostacyclin dehydrogenase activity" RELATED [EC:1.1.1.231]
xref: EC:1.1.1.231
xref: KEGG_REACTION:R03520
xref: MetaCyc:1.1.1.231-RXN
xref: RHEA:21420
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047034
name: 15-hydroxyicosatetraenoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN]
synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" RELATED [EC:1.1.1.232]
synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" RELATED [EC:1.1.1.232]
xref: EC:1.1.1.232
xref: MetaCyc:1.1.1.232-RXN
xref: Reactome:R-HSA-2161789 "15S-HETE is oxidised to 15-oxoETE by 15-HEDH"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047035
name: testosterone dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0050327
def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [RHEA:14929]
synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.239]
synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.239]
synonym: "17beta-HSD" RELATED [EC:1.1.1.239]
synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" RELATED [EC:1.1.1.239]
synonym: "3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.239]
synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239]
synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" BROAD [EC:1.1.1.239]
synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.239]
synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.239]
synonym: "testosterone 17-beta-dehydrogenase (NAD+) activity" EXACT []
synonym: "testosterone 17b-dehydrogenase activity" EXACT []
synonym: "testosterone 17beta-dehydrogenase activity" RELATED [EC:1.1.1.239]
xref: EC:1.1.1.239
xref: KEGG_REACTION:R01836
xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
xref: RHEA:14929
xref: Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+)
is_a: GO:0030283 ! testosterone dehydrogenase [NAD(P)+] activity
is_a: GO:0044594 ! 17-beta-hydroxysteroid dehydrogenase (NAD+) activity

[Term]
id: GO:0047036
name: codeinone reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: codeine + NADP+ = codeinone + H+ + NADPH." [EC:1.1.1.247, RHEA:19209]
synonym: "codeine:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.247]
xref: EC:1.1.1.247
xref: KEGG_REACTION:R05124
xref: MetaCyc:1.1.1.247-RXN
xref: RHEA:19209
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047037
name: salutaridine reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine." [EC:1.1.1.248, RHEA:10108]
synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" RELATED [EC:1.1.1.248]
xref: EC:1.1.1.248
xref: KEGG_REACTION:R04697
xref: MetaCyc:1.1.1.248-RXN
xref: RHEA:10108
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047038
name: D-arabinitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-ribulose + H+ + NADH." [EC:1.1.1.250, RHEA:17389]
synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" RELATED [EC:1.1.1.250]
synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" RELATED [EC:1.1.1.250]
xref: EC:1.1.1.250
xref: KEGG_REACTION:R07134
xref: MetaCyc:1.1.1.250-RXN
xref: RHEA:17389
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047039
name: tetrahydroxynaphthalene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN]
synonym: "scytalone:NADP+ delta5-oxidoreductase activity" RELATED [EC:1.1.1.252]
synonym: "T4HN reductase activity" RELATED [EC:1.1.1.252]
xref: EC:1.1.1.252
xref: MetaCyc:1.1.1.252-RXN
xref: RHEA:21908
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047040
name: pteridine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 H+ + 2 NADPH." [EC:1.5.1.33, RHEA:19509]
synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.33]
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e]
synonym: "PTR1" RELATED [EC:1.5.1.33]
synonym: "ptr1 activity" NARROW [EC:1.5.1.33e]
xref: EC:1.5.1.33
xref: KEGG_REACTION:R01812
xref: MetaCyc:1.1.1.253-RXN
xref: RHEA:19509
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047041
name: (S)-carnitine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH." [EC:1.1.1.254, RHEA:11556]
synonym: "(S)-carnitine:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.254]
synonym: "D-carnitine dehydrogenase activity" RELATED [EC:1.1.1.254]
xref: EC:1.1.1.254
xref: KEGG_REACTION:R01921
xref: MetaCyc:1.1.1.254-RXN
xref: RHEA:11556
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047042
name: androsterone dehydrogenase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50]
synonym: "3-alpha-HSD activity" RELATED [EC:1.1.1.50]
synonym: "3-alpha-hydroxysteroid dehydrogenase (B-specific) activity" BROAD [EC:1.1.1.50]
synonym: "3alpha-HSD" RELATED [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" BROAD [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" BROAD [EC:1.1.1.50]
synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50]
synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50]
xref: EC:1.1.1.50
xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific)
is_a: GO:0047023 ! androsterone dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0047043
name: 3-alpha-hydroxycholanate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: lithocholate + NAD+ = 3-oxo-5beta-cholanate + H+ + NADH." [EC:1.1.1.52, RHEA:19585]
synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.52]
synonym: "3alpha-hydroxycholanate dehydrogenase activity" RELATED [EC:1.1.1.52]
synonym: "alpha-hydroxy-cholanate dehydrogenase activity" RELATED [EC:1.1.1.52]
xref: EC:1.1.1.52
xref: KEGG_REACTION:R04139
xref: MetaCyc:1.1.1.52-RXN
xref: RHEA:19585
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047044
name: androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [RHEA:22400]
synonym: "(R)-20-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53]
synonym: "20beta-HSD" RELATED [EC:1.1.1.53]
synonym: "20beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53]
synonym: "3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53]
synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53]
synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.53]
synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" BROAD [EC:1.1.1.53]
synonym: "cortisone reductase activity" RELATED [EC:1.1.1.53]
synonym: "dehydrogenase, 20beta-hydroxy steroid" BROAD [EC:1.1.1.53]
synonym: "delta4-3-ketosteroid hydrogenase activity" BROAD [EC:1.1.1.53]
synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53]
xref: EC:1.1.1.53
xref: MetaCyc:1.1.1.53-RXN
xref: RHEA:22400
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047045
name: testosterone 17-beta-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN]
synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64]
synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" RELATED [EC:1.1.1.64]
synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" RELATED [EC:1.1.1.64]
synonym: "testosterone 17beta-dehydrogenase (NADP+)" RELATED [EC:1.1.1.64]
xref: EC:1.1.1.64
xref: KEGG_REACTION:R01838
xref: MetaCyc:1.1.1.64-RXN
xref: RHEA:14981
xref: Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+)
is_a: GO:0030283 ! testosterone dehydrogenase [NAD(P)+] activity
is_a: GO:0072582 ! 17-beta-hydroxysteroid dehydrogenase (NADP+) activity

[Term]
id: GO:0047046
name: homoisocitrate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0047984
def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.87]
comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical.
synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" RELATED [EC:1.1.1.87]
synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.87]
synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.87]
synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" RELATED [EC:1.1.1.87]
synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT []
synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" RELATED [EC:1.1.1.87]
synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.87]
synonym: "homoisocitric dehydrogenase activity" RELATED [EC:1.1.1.87]
xref: EC:1.1.1.87
xref: RHEA:11900
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047047
name: oxaloglycolate reductase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN]
synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" RELATED [EC:1.1.1.92]
xref: EC:1.1.1.92
xref: MetaCyc:1.1.1.92-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047048
name: 3-hydroxybenzyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP+ = 3-hydroxybenzaldehyde + H+ + NADPH." [EC:1.1.1.97, RHEA:22340]
synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.97]
synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" RELATED [EC:1.1.1.97]
synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" RELATED [EC:1.1.1.97]
synonym: "m-hydroxybenzylalcohol dehydrogenase activity" RELATED [EC:1.1.1.97]
xref: EC:1.1.1.97
xref: KEGG_REACTION:R04136
xref: MetaCyc:1.1.1.97-RXN
xref: RHEA:22340
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047049
name: (R)-2-hydroxy-fatty acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH." [EC:1.1.1.98, RHEA:15949]
synonym: "(R)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT []
synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.98]
synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98]
synonym: "D-2-hydroxy fatty acid dehydrogenase activity" RELATED [EC:1.1.1.98]
xref: EC:1.1.1.98
xref: KEGG_REACTION:R03021
xref: MetaCyc:1.1.1.98-RXN
xref: RHEA:15949
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047050
name: (S)-2-hydroxy-fatty acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH." [EC:1.1.1.99, RHEA:11384]
synonym: "(S)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT []
synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.99]
synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99]
synonym: "dehydrogenase, L-2-hydroxy fatty acid" RELATED [EC:1.1.1.99]
synonym: "L-2-hydroxy fatty acid dehydrogenase activity" RELATED [EC:1.1.1.99]
xref: EC:1.1.1.99
xref: KEGG_REACTION:R03022
xref: MetaCyc:1.1.1.99-RXN
xref: RHEA:11384
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047051
name: D-lactate dehydrogenase (cytochrome c-553) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate." [RHEA:16465]
synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" RELATED [EC:1.1.2.5]
xref: EC:1.1.2.5
xref: MetaCyc:1.1.2.5-RXN
xref: RHEA:16465
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0047052
name: (S)-stylopine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:13773]
synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" RELATED [EC:1.14.19.64]
synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" RELATED [EC:1.14.19.64]
xref: EC:1.14.19.64
xref: KEGG_REACTION:R04690
xref: MetaCyc:1.1.3.32-RXN
xref: RHEA:13773
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0047053
name: (S)-cheilanthifoline synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 = (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:20485]
synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT []
xref: EC:1.14.19.65
xref: KEGG_REACTION:R03834
xref: MetaCyc:1.14.21.2-RXN
xref: RHEA:20485
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0047054
name: berbamunine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:23576]
synonym: "heme-thiolate" RELATED [EC:1.14.19.66]
xref: EC:1.14.19.66
xref: MetaCyc:1.1.3.34-RXN
xref: RHEA:23576
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0047055
name: salutaridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:17713]
synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" RELATED []
xref: EC:1.14.19.67
xref: KEGG_REACTION:R04696
xref: MetaCyc:1.1.3.35-RXN
xref: RHEA:17713
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0047056
name: (S)-canadine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:21456]
synonym: "(S)-tetrahydroberberine synthase activity" RELATED [EC:1.14.19.68]
synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" RELATED [EC:1.14.19.68]
xref: EC:1.14.19.68
xref: KEGG_REACTION:R04400
xref: MetaCyc:1.1.3.36-RXN
xref: RHEA:21456
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0047057
name: vitamin-K-epoxide reductase (warfarin-sensitive) activity
namespace: molecular_function
def: "Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues." [RHEA:57744]
synonym: "phylloquinone epoxide reductase activity" RELATED [EC:1.17.4.4]
synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.17.4.4]
xref: EC:1.17.4.4
xref: MetaCyc:1.1.4.1-RXN
xref: Reactome:R-HSA-159790 "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)"
xref: Reactome:R-HSA-6806647 "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)"
xref: RHEA:57744
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0047058
name: vitamin-K-epoxide reductase (warfarin-insensitive) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [RHEA:21560]
synonym: "vitamin K 2,3-epoxide reductase activity" RELATED [EC:1.17.4.5]
xref: EC:1.17.4.5
xref: MetaCyc:1.1.4.2-RXN
xref: RHEA:21560
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0047059
name: polyvinyl alcohol dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+." [EC:1.1.2.6]
synonym: "polyvinyl alcohol:ferricytochrome-c oxidoreductase activity" EXACT []
synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" BROAD []
synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" BROAD []
synonym: "PVA dehydrogenase activity" BROAD [EC:1.1.2.6]
xref: EC:1.1.2.6
xref: KEGG_REACTION:R03136
xref: MetaCyc:RXN-11316
xref: RHEA:20157
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0047060
name: (R)-pantolactone dehydrogenase (flavin) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)." [EC:1.1.99.27, RHEA:21004]
synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" RELATED [EC:1.1.99.27]
synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" RELATED [EC:1.1.99.27]
synonym: "2-dehydropantolactone reductase (flavin) activity" RELATED [EC:1.1.99.27]
synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" RELATED [EC:1.1.99.27]
xref: EC:1.1.99.27
xref: KEGG_REACTION:R03156
xref: MetaCyc:1.1.99.27-RXN
xref: RHEA:21004
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047061
name: glucose-fructose oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone." [EC:1.1.99.28, RHEA:20637]
synonym: "D-glucose:D-fructose oxidoreductase activity" RELATED [EC:1.1.99.28]
xref: EC:1.1.99.28
xref: KEGG_REACTION:R00874
xref: MetaCyc:1.1.99.28-RXN
xref: RHEA:20637
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047062
name: trans-acenaphthene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthene-1,2-dione + 2 H+ + 2 NADPH." [EC:1.10.1.1, RHEA:22184]
synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" RELATED [EC:1.10.1.1]
synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" RELATED [EC:1.10.1.1]
xref: EC:1.10.1.1
xref: KEGG_REACTION:R04059
xref: MetaCyc:1.10.1.1-RXN
xref: RHEA:22184
is_a: GO:0016680 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor

[Term]
id: GO:0047063
name: obsolete L-ascorbate-cytochrome-b5 reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [GOC:curators]
comment: This term was obsoleted because the EC (EC:1.10.2.1) and RHEA (RHEA:18677) it represented was obsoleted.
synonym: "ascorbate-cytochrome b5 reductase activity" RELATED [EC:1.10.2.1]
synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" RELATED [EC:1.10.2.1]
is_obsolete: true

[Term]
id: GO:0047064
name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O." [EC:1.21.3.4, RHEA:24092]
synonym: "sulochrin oxidase activity" RELATED [EC:1.21.3.4]
synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" RELATED [EC:1.21.3.4]
xref: EC:1.21.3.4
xref: KEGG_REACTION:R00060
xref: MetaCyc:1.10.3.7-RXN
xref: RHEA:24092
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0047065
name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O." [EC:1.21.3.5, RHEA:22616]
synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5]
synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" RELATED [EC:1.21.3.5]
xref: EC:1.21.3.5
xref: KEGG_REACTION:R00061
xref: MetaCyc:1.10.3.8-RXN
xref: RHEA:22616
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0047066
name: phospholipid-hydroperoxide glutathione peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O." [PMID:3978121, PMID:8617728, RHEA:19057]
synonym: "hydroperoxide glutathione peroxidase activity" RELATED []
synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12]
synonym: "phospholipid hydroperoxide glutathione peroxidase activity" RELATED []
xref: EC:1.11.1.12
xref: MetaCyc:1.11.1.12-RXN
xref: Reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE"
xref: Reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE"
xref: Reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA"
xref: Reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA"
xref: RHEA:19057
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0047067
name: hydrogen:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone." [EC:1.12.5.1, RHEA:18641]
synonym: "hydrogen-ubiquinone oxidoreductase activity" RELATED [EC:1.12.5.1]
synonym: "hydrogen:menaquinone oxidoreductase activity" RELATED [EC:1.12.5.1]
synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1]
synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1]
xref: EC:1.12.5.1
xref: KEGG_REACTION:R02965
xref: MetaCyc:1.12.5.1-RXN
xref: RHEA:18641
is_a: GO:0046994 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor

[Term]
id: GO:0047068
name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity
namespace: molecular_function
alt_id: GO:0016947
def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H+." [EC:1.12.98.2, RHEA:20017]
synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" RELATED [EC:1.12.98.2]
synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" RELATED [EC:1.12.98.2]
synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.12.98.2]
synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" RELATED [EC:1.12.98.2]
synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.12.98.2]
synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" RELATED [EC:1.12.98.2]
synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" RELATED [EC:1.12.98.2]
synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" RELATED [EC:1.12.98.2]
synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" RELATED [EC:1.12.98.2]
synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT []
synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2]
xref: EC:1.12.98.2
xref: KEGG_REACTION:R04455
xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN
xref: RHEA:20017
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0047069
name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+." [EC:1.13.11.10, RHEA:23400]
synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" RELATED [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate oxygenase activity" RELATED [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.10]
xref: EC:1.13.11.10
xref: KEGG_REACTION:R03253
xref: MetaCyc:1.13.11.10-RXN
xref: RHEA:23400
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047070
name: 3-carboxyethylcatechol 2,3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0008669
def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN]
synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" RELATED [EC:1.13.11.16]
synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" RELATED [EC:1.13.11.16]
synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.16]
synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" RELATED [EC:1.13.11.16]
xref: EC:1.13.11.16
xref: MetaCyc:1.13.11.16-RXN
xref: RHEA:23840
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047071
name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H+." [EC:1.13.11.25, RHEA:21352]
synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.25]
synonym: "3-alkylcatechol 2,3-dioxygenase activity" RELATED [EC:1.13.11.25]
synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25]
xref: EC:1.13.11.25
xref: KEGG_REACTION:R04597
xref: MetaCyc:1.13.11.25-RXN
xref: RHEA:21352
xref: UM-BBD_reactionID:r1151
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047072
name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H+." [EC:1.13.11.28, RHEA:15369]
synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" RELATED [EC:1.13.11.28]
synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.28]
xref: EC:1.13.11.28
xref: KEGG_REACTION:R01506
xref: MetaCyc:1.13.11.28-RXN
xref: RHEA:15369
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047073
name: 2,4'-dihydroxyacetophenone dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H+." [EC:1.13.11.41, RHEA:24416]
synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" RELATED [EC:1.13.11.41]
synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" RELATED [EC:1.13.11.41]
xref: EC:1.13.11.41
xref: KEGG_REACTION:R01305
xref: MetaCyc:1.13.11.41-RXN
xref: RHEA:24416
xref: UM-BBD_reactionID:r1410
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047074
name: 4-hydroxycatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = maleylacetate + 2 H+." [RHEA:35595]
xref: EC:1.13.11.37
xref: MetaCyc:RXN-10137
xref: RHEA:35595
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047075
name: 2,5-dihydroxypyridine 5,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN]
synonym: "2,5-dihydroxypyridine oxygenase activity" RELATED [EC:1.13.11.9]
synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" RELATED [EC:1.13.11.9]
synonym: "pyridine-2,5-diol dioxygenase activity" RELATED [EC:1.13.11.9]
xref: EC:1.13.11.9
xref: MetaCyc:1.13.11.9-RXN
xref: RHEA:27522
xref: UM-BBD_reactionID:r1443
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047077
name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]
synonym: "firefly luciferase activity" RELATED [EC:1.13.12.7]
synonym: "firefly luciferin luciferase activity" RELATED [EC:1.13.12.7]
synonym: "luciferase (firefly luciferin)" RELATED [EC:1.13.12.7]
synonym: "luciferase activity" BROAD [EC:1.13.12.7]
synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" RELATED [EC:1.13.12.7]
synonym: "Photinus pyralis luciferase activity" RELATED [EC:1.13.12.7]
synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" RELATED [EC:1.13.12.7]
synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" RELATED [EC:1.13.12.7]
xref: EC:1.13.12.7
xref: MetaCyc:1.13.12.7-RXN
xref: RHEA:10732
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047078
name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN]
synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" RELATED [EC:1.13.11.47]
synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT []
synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" RELATED [EC:1.13.11.47]
synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" RELATED [EC:1.13.11.47]
synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" RELATED [EC:1.13.11.47]
synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" RELATED [EC:1.13.11.47]
xref: EC:1.13.11.47
xref: MetaCyc:1.13.11.47-RXN
xref: RHEA:17949
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047079
name: deoxyuridine 1'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil." [EC:1.14.11.10, RHEA:23316]
synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" RELATED [EC:1.14.11.10]
synonym: "pyrimidine-deoxynucleoside 1'-dioxygenase activity" BROAD [EC:1.14.11.10]
synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" BROAD [EC:1.14.11.10]
xref: EC:1.14.11.10
xref: KEGG_REACTION:R02486
xref: MetaCyc:1.14.11.10-RXN
xref: RHEA:23316
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0047080
name: deoxyuridine 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine." [EC:1.14.11.3, RHEA:21076]
synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" RELATED [EC:1.14.11.3]
synonym: "deoxyuridine 2'-hydroxylase activity" RELATED [EC:1.14.11.3]
synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" BROAD [EC:1.14.11.3]
synonym: "pyrimidine-deoxynucleoside 2'-dioxygenase activity" BROAD [EC:1.14.11.3]
synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" BROAD [EC:1.14.11.3]
synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3]
synonym: "thymidine 2'-hydroxylase activity" RELATED [EC:1.14.11.3]
synonym: "thymidine 2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.3]
synonym: "thymidine dioxygenase activity" RELATED [EC:1.14.11.3]
xref: EC:1.14.11.3
xref: KEGG_REACTION:R01879
xref: MetaCyc:1.14.11.3-RXN
xref: RHEA:21076
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0047081
name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate." [EC:1.14.13.242, MetaCyc:1.14.12.4-RXN]
synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" RELATED [EC:1.14.13.242]
synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)" RELATED [EC:1.14.13.242]
synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" RELATED [EC:1.14.13.242]
synonym: "methylhydroxypyridine carboxylate dioxygenase activity" RELATED [EC:1.14.13.242]
synonym: "methylhydroxypyridinecarboxylate oxidase activity" RELATED [EC:1.14.13.242]
xref: EC:1.14.13.242
xref: MetaCyc:1.14.12.4-RXN
xref: RHEA:10864
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0047082
name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H+ + NADPH + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.14.93, RHEA:15321]
synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" RELATED [EC:1.14.14.93]
synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT []
synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase" RELATED []
xref: EC:1.14.14.93
xref: KEGG_REACTION:R03452
xref: MetaCyc:RXN-4505
xref: RHEA:15321
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047083
name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.14.96, MetaCyc:1.14.13.36-RXN]
synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT []
synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" RELATED [EC:1.14.14.96]
synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.96]
xref: EC:1.14.14.96
xref: MetaCyc:1.14.13.36-RXN
xref: RHEA:16265
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047084
name: methyltetrahydroprotoberberine 14-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.14.97, MetaCyc:1.14.13.37-RXN]
synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" RELATED [EC:1.14.14.97]
synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" RELATED [EC:1.14.14.97]
synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" RELATED [EC:1.14.14.97]
synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT []
xref: EC:1.14.14.97
xref: MetaCyc:1.14.13.37-RXN
xref: RHEA:23684
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047085
name: hydroxyphenylacetonitrile 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H+ + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP+." [RHEA:50732]
synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT []
synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT []
synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT []
xref: KEGG_REACTION:R02708
xref: MetaCyc:1.14.13.42-RXN
xref: RHEA:50732
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047086
name: ketosteroid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]
synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" RELATED [EC:1.14.13.54]
synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" RELATED [EC:1.14.13.54]
synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" RELATED [EC:1.14.13.54]
synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" RELATED [EC:1.14.13.54]
synonym: "steroid-ketone monooxygenase activity" RELATED [EC:1.14.13.54]
xref: EC:1.14.13.54
xref: MetaCyc:1.14.13.54-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047087
name: protopine 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:22644]
synonym: "protopine 6-hydroxylase activity" EXACT []
synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.14.98]
xref: EC:1.14.14.98
xref: KEGG_REACTION:R04699
xref: MetaCyc:1.14.13.55-RXN
xref: RHEA:22644
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047088
name: dihydrosanguinarine 10-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrosanguinarine + H+ + NADPH + O2 = 10-hydroxydihydrosanguinarine + H2O + NADP+." [EC:1.14.14.100, RHEA:10528]
synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT []
synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" RELATED [EC:1.14.14.100]
xref: EC:1.14.14.100
xref: KEGG_REACTION:R04702
xref: MetaCyc:1.14.13.56-RXN
xref: RHEA:10528
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047089
name: dihydrochelirubine 12-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrochelirubine + H+ + NADPH + O2 = 12-hydroxydihydrochelirubine + H2O + NADP+." [EC:1.14.14.101, RHEA:10156]
synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT []
synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" RELATED [EC:1.14.14.101]
xref: EC:1.14.14.101
xref: KEGG_REACTION:R04708
xref: MetaCyc:1.14.13.57-RXN
xref: RHEA:10156
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047090
name: benzoyl-CoA 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + H+ + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP+." [EC:1.14.13.58, RHEA:23216]
synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT []
synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.58]
xref: EC:1.14.13.58
xref: KEGG_REACTION:R02449
xref: MetaCyc:1.14.13.58-RXN
xref: RHEA:23216
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047091
name: L-lysine 6-monooxygenase (NADPH) activity
namespace: molecular_function
alt_id: GO:0008739
def: "Catalysis of the reaction: L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + H2O + NADP+." [EC:1.14.13.59, RHEA:23228]
comment: Note that EC:1.13.12.10 was merged into this term.
synonym: "L-lysine 6-monooxygenase activity" EXACT []
synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.59]
synonym: "lysine N(6)-hydroxylase activity" RELATED [EC:1.14.13.59]
synonym: "lysine N6-hydroxylase activity" EXACT []
xref: EC:1.14.13.59
xref: KEGG_REACTION:R00448
xref: MetaCyc:1.14.13.59-RXN
xref: RHEA:23228
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047092
name: obsolete 27-hydroxycholesterol 7-alpha-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [RHEA:24308]
comment: This term was obsoleted because it represents a specific reaction of 25-hydroxycholesterol 7alpha-hydroxylase activity ; GO:0033783.
synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT []
synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT []
is_obsolete: true
replaced_by: GO:0033783

[Term]
id: GO:0047093
name: 4-hydroxyquinoline 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol." [EC:1.14.13.62, RHEA:19325]
synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" RELATED [EC:1.14.13.62]
synonym: "quinolin-4(1H)-one 3-monooxygenase activity" RELATED [EC:1.14.13.62]
synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" RELATED [EC:1.14.13.62]
xref: EC:1.14.13.62
xref: KEGG_REACTION:R05154
xref: MetaCyc:1.14.13.62-RXN
xref: RHEA:19325
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047094
name: 3-hydroxyphenylacetate 6-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63]
synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" RELATED [EC:1.14.13.63]
synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.63]
xref: EC:1.14.13.63
xref: MetaCyc:1.14.13.63-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047095
name: 2-hydroxycyclohexanone 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP+." [EC:1.14.13.66, RHEA:33283]
synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" RELATED [EC:1.14.13.66]
xref: EC:1.14.13.66
xref: KEGG_REACTION:R03281
xref: MetaCyc:1.14.13.66-RXN
xref: RHEA:33283
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047096
name: androst-4-ene-3,17-dione monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone." [EC:1.14.99.12, RHEA:22696]
synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT []
synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" RELATED [EC:1.14.99.12]
synonym: "androst-4-ene-3,17-dione hydroxylase activity" RELATED [EC:1.14.99.12]
synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" RELATED [EC:1.14.99.12]
synonym: "androstene-3,17-dione hydroxylase activity" EXACT []
synonym: "androstenedione monooxygenase activity" RELATED [EC:1.14.99.12]
xref: EC:1.14.99.12
xref: KEGG_REACTION:R01833
xref: MetaCyc:1.14.99.12-RXN
xref: RHEA:22696
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047097
name: phylloquinone monooxygenase (2,3-epoxidizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O." [RHEA:16745]
synonym: "phylloquinone epoxidase activity" RELATED [EC:1.14.99.20]
synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" RELATED [EC:1.14.99.20]
synonym: "vitamin K 2,3-epoxidase activity" RELATED [EC:1.14.99.20]
synonym: "vitamin K epoxidase activity" RELATED [EC:1.14.99.20]
synonym: "vitamin K1 epoxidase activity" RELATED [EC:1.14.99.20]
xref: EC:1.14.99.20
xref: KEGG_REACTION:R03510
xref: MetaCyc:1.14.99.20-RXN
xref: RHEA:16745
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047098
name: Latia-luciferin monooxygenase (demethylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN]
synonym: "Latia luciferin monooxygenase (demethylating)" RELATED [EC:1.14.99.21]
synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" RELATED [EC:1.14.99.21]
synonym: "luciferase (Latia luciferin)" RELATED [EC:1.14.99.21]
xref: EC:1.14.99.21
xref: MetaCyc:1.14.99.21-RXN
xref: RHEA:12677
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047099
name: CDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN]
synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" RELATED [EC:1.17.1.1]
synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" RELATED [EC:1.17.1.1]
synonym: "CDP-4-keto-6-deoxyglucose reductase activity" RELATED [EC:1.17.1.1]
synonym: "CDP-4-keto-deoxy-glucose reductase activity" RELATED [EC:1.17.1.1]
synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" RELATED [EC:1.17.1.1]
synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" RELATED [EC:1.17.1.1]
synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" RELATED [EC:1.17.1.1]
xref: EC:1.17.1.1
xref: MetaCyc:1.17.1.1-RXN
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0047100
name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN]
synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.13]
synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" RELATED [EC:1.2.1.13]
synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" RELATED [EC:1.2.1.13]
synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" RELATED [EC:1.2.1.13]
synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" RELATED [EC:1.2.1.13]
synonym: "NADP-triose phosphate dehydrogenase activity" RELATED [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP(+)) activity" RELATED [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP)" RELATED [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP+) activity" RELATED [EC:1.2.1.13]
xref: EC:1.2.1.13
xref: MetaCyc:1.2.1.13-RXN
xref: RHEA:10296
is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity

[Term]
id: GO:0047101
name: branched-chain alpha-keto acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs." [EC:1.2.1.25]
synonym: "2-oxoisovalerate dehydrogenase (acylating) activity" NARROW [EC:1.2.1.25]
synonym: "2-oxoisovalerate dehydrogenase activity" RELATED [EC:1.2.1.25]
synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" RELATED [EC:1.2.1.25]
xref: EC:1.2.1.25
xref: MetaCyc:1.2.1.25-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047102
name: aminomuconate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN]
synonym: "2-aminomuconate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32]
synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" RELATED [EC:1.2.1.32]
synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32]
synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32]
synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32]
synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32]
synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32]
xref: EC:1.2.1.32
xref: MetaCyc:1.2.1.32-RXN
xref: Reactome:R-HSA-71239 "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+"
xref: RHEA:14469
xref: UM-BBD_reactionID:r1434
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047103
name: obsolete 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [PMID:8496170]
comment: This term was obsoleted because it represents a sub-reaction of cholestanetetraol 26-dehydrogenase activity ; GO:0047748.
synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT []
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT []
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT []
synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT []
synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT []
synonym: "cholestanetriol-26-al 26-dehydrogenase activity" RELATED []
synonym: "THAL-NAD oxidoreductase activity" EXACT []
synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047748

[Term]
id: GO:0047104
name: hexadecanal dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + NAD+ + palmitaldehyde = H+ + NADH + palmitoyl-CoA." [EC:1.2.1.42, RHEA:19705]
synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42]
synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" RELATED [EC:1.2.1.42]
xref: EC:1.2.1.42
xref: KEGG_REACTION:R01277
xref: MetaCyc:1.2.1.42-RXN
xref: RHEA:19705
xref: UM-BBD_reactionID:r1374
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047105
name: 4-trimethylammoniobutyraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN]
synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.47]
synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.47]
synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" RELATED [EC:1.2.1.47]
xref: EC:1.2.1.47
xref: MetaCyc:1.2.1.47-RXN
xref: Reactome:R-HSA-71260 "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT"
xref: RHEA:17985
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047106
name: 4-hydroxyphenylacetaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)acetaldehyde + H2O + NAD+ = 4-hydroxyphenylacetate + 2 H+ + NADH." [RHEA:17273]
synonym: "4-HPAL dehydrogenase activity" RELATED [EC:1.2.1.53]
synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.53]
xref: EC:1.2.1.53
xref: MetaCyc:1.2.1.53-RXN
xref: RHEA:17273
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0047107
name: gamma-guanidinobutyraldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-guanidinobutanal + H2O + NAD+ = 4-guanidinobutanoate + 2 H+ + NADH." [RHEA:14381]
synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" RELATED [EC:1.2.1.54]
synonym: "4-guanidinobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.54]
synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.54]
synonym: "GBAL dehydrogenase activity" RELATED [EC:1.2.1.54]
xref: EC:1.2.1.54
xref: KEGG_REACTION:R03177
xref: MetaCyc:1.2.1.54-RXN
xref: RHEA:14381
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0047108
name: (R)-3-hydroxyacid-ester dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH." [EC:1.1.1.279, RHEA:24352]
comment: Note that this term was EC:1.2.1.55.
synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT []
synonym: "3-oxo ester (R)-reductase activity" RELATED [EC:1.1.1.279]
synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.279]
xref: EC:1.1.1.279
xref: KEGG_REACTION:R04105
xref: MetaCyc:1.2.1.55-RXN
xref: RHEA:24352
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047109
name: (S)-3-hydroxyacid-ester dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH." [EC:1.1.1.280, RHEA:18269]
comment: Note that this term was EC:1.2.1.56.
synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT []
synonym: "3-oxo ester (S)-reductase activity" RELATED [EC:1.1.1.280]
synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.280]
xref: EC:1.1.1.280
xref: KEGG_REACTION:R04106
xref: MetaCyc:1.2.1.56-RXN
xref: RHEA:18269
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047110
name: phenylglyoxylate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH." [RHEA:10372]
synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.58]
xref: EC:1.2.1.58
xref: KEGG_REACTION:R02450
xref: MetaCyc:1.2.1.58-RXN
xref: RHEA:10372
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047111
name: formate dehydrogenase (cytochrome-c-553) activity
namespace: molecular_function
def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.17.2.3, MetaCyc:1.2.2.3-RXN]
synonym: "formate dehydrogenase (cytochrome c-553)" RELATED [EC:1.17.2.3]
synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" RELATED [EC:1.17.2.3]
xref: EC:1.17.2.3
xref: MetaCyc:1.2.2.3-RXN
xref: RHEA:15189
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0047112
name: pyruvate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2." [RHEA:20848]
synonym: "phosphate-dependent pyruvate oxidase activity" RELATED [EC:1.2.3.3]
synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" RELATED [EC:1.2.3.3]
synonym: "pyruvic oxidase activity" RELATED [EC:1.2.3.3]
xref: EC:1.2.3.3
xref: KEGG_REACTION:R00207
xref: MetaCyc:1.2.3.3-RXN
xref: RHEA:20848
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0047113
name: aldehyde dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: a quinone + an aldehyde + H2O = a carboxylate + a quinol + H+." [RHEA:13881]
synonym: "aldehyde dehydrogenase (acceptor) activity" RELATED [EC:1.2.5.2]
synonym: "aldehyde dehydrogenase (pyrroloquinoline-quinone)" RELATED []
synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" RELATED [EC:1.2.5.2]
xref: EC:1.2.5.2
xref: MetaCyc:1.2.99.3-RXN
xref: RHEA:13881
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047114
name: kynurenate-7,8-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + H+ + NADH." [EC:1.3.1.18, RHEA:22248]
synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" RELATED [EC:1.3.1.18]
synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.18]
synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" RELATED [EC:1.3.1.18]
xref: EC:1.3.1.18
xref: KEGG_REACTION:R03251
xref: MetaCyc:1.3.1.18-RXN
xref: RHEA:22248
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047115
name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN]
synonym: "dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.20]
synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.20]
xref: EC:1.3.1.20
xref: MetaCyc:1.3.1.20-RXN
xref: RHEA:16729
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047116
name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN]
synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.25]
synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" RELATED [EC:1.3.1.25]
synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" RELATED [EC:1.3.1.25]
synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" RELATED [EC:1.3.1.25]
synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" RELATED [EC:1.3.1.25]
synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.25]
synonym: "DHB dehydrogenase activity" RELATED [EC:1.3.1.25]
synonym: "DHBDH activity" RELATED [EC:1.3.1.25]
synonym: "dihydrodihydroxybenzoate dehydrogenase activity" RELATED [EC:1.3.1.25]
xref: EC:1.3.1.25
xref: MetaCyc:1.3.1.25-RXN
xref: RHEA:11560
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047117
name: obsolete enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN]
comment: This term was obsoleted because it captures the stereospecificity of the NADPH cofactor, which is outside the scope of GO. Consider annotating to enoyl-[acyl-carrier-protein] reductase (NADPH) activity ; GO:0141148.
synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" RELATED [EC:1.3.1.39]
synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT []
synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT []
synonym: "enoyl-ACp reductase activity" RELATED [EC:1.3.1.39]
synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.3.1.39]
synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" RELATED [EC:1.3.1.39]
is_obsolete: true
replaced_by: GO:0141148

[Term]
id: GO:0047118
name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH." [EC:1.3.1.40, RHEA:24268]
synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.40]
synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.3.1.40]
xref: EC:1.3.1.40
xref: KEGG_REACTION:R03463
xref: MetaCyc:1.3.1.40-RXN
xref: RHEA:24268
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047120
name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0018514
def: "Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH." [EC:1.3.1.53, RHEA:10744]
synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" RELATED [EC:1.3.1.53]
synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.53]
synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.53]
synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" RELATED [EC:1.3.1.53]
synonym: "terephthalate 1,2-cis-dihydrodiol dehydrogenase activity" EXACT []
xref: EC:1.3.1.53
xref: KEGG_REACTION:R01633
xref: MetaCyc:1.3.1.53-RXN
xref: RHEA:10744
xref: UM-BBD_reactionID:r0151
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047121
name: isoquinoline 1-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H2O + isoquinoline = AH(2) + isoquinolin-1(2H)-one." [EC:1.3.99.16, RHEA:11588]
synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.16]
xref: EC:1.3.99.16
xref: KEGG_REACTION:R05151
xref: MetaCyc:1.3.99.16-RXN
xref: RHEA:11588
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047122
name: quinaldate 4-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H2O + quinaldate = AH(2) + kynurenate." [EC:1.3.99.18, RHEA:16697]
synonym: "quinaldic acid 4-oxidoreductase activity" RELATED [EC:1.3.99.18]
synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.18]
xref: EC:1.3.99.18
xref: KEGG_REACTION:R03687
xref: MetaCyc:1.3.99.18-RXN
xref: RHEA:16697
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047123
name: quinoline-4-carboxylate 2-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)." [EC:1.3.99.19, RHEA:14949]
synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.19]
synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" RELATED [EC:1.3.99.19]
xref: EC:1.3.99.19
xref: KEGG_REACTION:R05183
xref: MetaCyc:1.3.99.19-RXN
xref: RHEA:14949
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047124
name: L-erythro-3,5-diaminohexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxo-hexanoate + H+ + NADH + NH4." [EC:1.4.1.11, RHEA:19633]
synonym: "L-3,5-diaminohexanoate dehydrogenase activity" RELATED [EC:1.4.1.11]
synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.11]
xref: EC:1.4.1.11
xref: KEGG_REACTION:R03349
xref: MetaCyc:1.4.1.11-RXN
xref: RHEA:19633
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047125
name: delta1-piperideine-2-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate." [EC:1.5.1.21]
synonym: "1,2-didehydropipecolate reductase activity" RELATED [EC:1.5.1.21]
synonym: "1,2-didehydropipecolic reductase activity" RELATED [EC:1.5.1.21]
synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT []
synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT []
synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.5.1.21]
synonym: "P2C reductase activity" RELATED [EC:1.5.1.21]
xref: EC:1.5.1.21
xref: MetaCyc:RXN-8166
xref: RHEA:12524
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047126
name: N5-(carboxyethyl)ornithine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H2O + NADP+ = L-ornithine + H+ + NADPH + pyruvate." [EC:1.5.1.24, RHEA:18661]
synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" RELATED [EC:1.5.1.24]
synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" RELATED [EC:1.5.1.24]
xref: EC:1.5.1.24
xref: KEGG_REACTION:R00666
xref: MetaCyc:1.5.1.24-RXN
xref: RHEA:18661
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047127
name: thiomorpholine-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN]
synonym: "ketimine reductase activity" RELATED [EC:1.5.1.25]
synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25]
synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" RELATED [EC:1.5.1.25]
xref: EC:1.5.1.25
xref: MetaCyc:1.5.1.25-RXN
xref: Reactome:R-HSA-5693347 "CRYM reduces P2C to PPCA"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047128
name: 1,2-dehydroreticulinium reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticuline + H+ + NADPH." [EC:1.5.1.27, RHEA:17569]
synonym: "(R)-reticuline:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.27]
synonym: "1,2-dehydroreticulinium ion reductase activity" RELATED [EC:1.5.1.27]
xref: EC:1.5.1.27
xref: KEGG_REACTION:R04695
xref: MetaCyc:1.5.1.27-RXN
xref: RHEA:17569
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047129
name: opine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD+ = L-2-aminopentanoate + H+ + NADH + pyruvate." [EC:1.5.1.28, RHEA:21592]
synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" RELATED [EC:1.5.1.28]
synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" RELATED [EC:1.5.1.28]
xref: EC:1.5.1.28
xref: KEGG_REACTION:R03732
xref: MetaCyc:1.5.1.28-RXN
xref: RHEA:21592
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047130
name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
namespace: molecular_function
alt_id: GO:0010010
def: "Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH." [EC:1.5.1.8, RHEA:19373]
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.8]
synonym: "L-lysine-alpha-ketoglutarate reductase activity" RELATED [EC:1.5.1.8]
synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" RELATED [EC:1.5.1.8]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.8]
synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" RELATED [EC:1.5.1.8]
xref: EC:1.5.1.8
xref: KEGG_REACTION:R00716
xref: MetaCyc:1.5.1.8-RXN
xref: Reactome:R-HSA-70938 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O"
xref: RHEA:19373
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0047131
name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH." [EC:1.5.1.9, RHEA:24520]
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.9]
synonym: "aminoadipic semialdehyde synthase activity" RELATED [EC:1.5.1.9]
synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" RELATED [EC:1.5.1.9]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.9]
synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" RELATED [EC:1.5.1.9]
synonym: "saccharopin dehydrogenase activity" RELATED [EC:1.5.1.9]
xref: EC:1.5.1.9
xref: KEGG_REACTION:R02313
xref: MetaCyc:1.5.1.9-RXN
xref: Reactome:R-HSA-70940 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+"
xref: RHEA:24520
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0047132
name: dihydrobenzophenanthridine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12]
synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.12]
xref: EC:1.5.3.12
xref: MetaCyc:1.5.3.12-RXN
xref: RHEA:16621
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0047133
name: dimethylamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN]
synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" RELATED [EC:1.5.8.1]
synonym: "DMADh activity" RELATED [EC:1.5.8.1]
xref: EC:1.5.8.1
xref: MetaCyc:1.5.8.1-RXN
xref: RHEA:10204
xref: UM-BBD_reactionID:r1380
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0047134
name: protein-disulfide reductase (NAD(P)H) activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]
synonym: "disulfide reductase activity" RELATED [EC:1.8.1.8]
synonym: "insulin-glutathione transhydrogenase activity" RELATED [EC:1.8.1.8]
synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" RELATED [EC:1.8.1.8]
synonym: "protein disulfide reductase (NAD(P)H) activity" EXACT []
synonym: "protein disulfide reductase activity" RELATED [EC:1.8.1.8]
synonym: "protein disulphide reductase activity" RELATED [EC:1.8.1.8]
synonym: "protein-disulfide reductase (NAD(P)) activity" EXACT []
synonym: "protein-disulfide reductase activity" BROAD []
synonym: "protein-disulphide reductase activity" BROAD []
xref: EC:1.8.1.8
xref: MetaCyc:1.6.4.4-RXN
is_a: GO:0015035 ! protein-disulfide reductase activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0047135
name: bis-gamma-glutamylcystine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP+ = bis-gamma-glutamylcystine + H+ + NADPH." [EC:1.8.1.13, RHEA:11980]
synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT []
synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" RELATED [EC:1.8.1.13]
synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" RELATED [EC:1.8.1.13]
synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.13]
synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" RELATED [EC:1.8.1.13]
synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" RELATED [EC:1.8.1.13]
xref: EC:1.8.1.13
xref: KEGG_REACTION:R02742
xref: MetaCyc:1.6.4.9-RXN
xref: RHEA:11980
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0047136
name: 4-(dimethylamino)phenylazoxybenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(dimethylamino)azobenzene + H2O + NADP+ = 4-(dimethylamino)phenylazoxybenzene + H+ + NADPH." [EC:1.7.1.11, RHEA:19789]
synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.11]
synonym: "dimethylaminoazobenzene N-oxide reductase activity" RELATED [EC:1.7.1.11]
synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" RELATED [EC:1.7.1.11]
synonym: "NADPH-dependent DMAB N-oxide reductase activity" RELATED [EC:1.7.1.11]
synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" RELATED [EC:1.7.1.11]
synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" RELATED [EC:1.7.1.11]
xref: EC:1.7.1.11
xref: KEGG_REACTION:R04303
xref: MetaCyc:1.6.6.12-RXN
xref: RHEA:19789
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0047137
name: N-hydroxy-2-acetamidofluorene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12]
synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" RELATED [EC:1.7.1.12]
synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" RELATED [EC:1.7.1.12]
synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" RELATED [EC:1.7.1.12]
synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" RELATED [EC:1.7.1.12]
xref: EC:1.7.1.12
xref: MetaCyc:1.7.1.12-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0047138
name: obsolete aquacobalamin reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN]
comment: The term was obsoleted because it is not known to be catalyzed by any gene product.
synonym: "aquocobalamin reductase activity" RELATED [EC:1.16.1.3]
synonym: "B(12a) reductase activity" RELATED [EC:1.16.1.3]
synonym: "B12a reductase activity" RELATED [EC:1.16.1.3]
synonym: "cob(II)alamin:NAD+ oxidoreductase activity" RELATED [EC:1.16.1.3]
synonym: "NADH-linked aquacobalamin reductase activity" RELATED [EC:1.16.1.3]
synonym: "NADH2:cob(III)alamin oxidoreductase activity" RELATED [EC:1.16.1.3]
synonym: "NADH:cob(III)alamin oxidoreductase activity" RELATED [EC:1.16.1.3]
synonym: "vitamin B(12a) reductase activity" RELATED [EC:1.16.1.3]
synonym: "vitamin B12a reductase activity" RELATED [EC:1.16.1.3]
is_obsolete: true

[Term]
id: GO:0047139
name: glutathione-homocystine transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN]
synonym: "glutathione:homocystine oxidoreductase activity" RELATED [EC:1.8.4.1]
xref: EC:1.8.4.1
xref: MetaCyc:1.8.4.1-RXN
xref: RHEA:11464
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047140
name: glutathione-CoA-glutathione transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN]
synonym: "CoA:glutathione-disulfide oxidoreductase activity" RELATED [EC:1.8.4.3]
synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" RELATED [EC:1.8.4.3]
synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" RELATED [EC:1.8.4.3]
synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" RELATED [EC:1.8.4.3]
synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" RELATED [EC:1.8.4.3]
synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" RELATED [EC:1.8.4.3]
xref: EC:1.8.4.3
xref: MetaCyc:1.8.4.3-RXN
xref: RHEA:13125
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047141
name: glutathione-cystine transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN]
synonym: "glutathione:cystine oxidoreductase" RELATED [EC:1.8.4.4]
synonym: "GSH-cystine transhydrogenase" RELATED [EC:1.8.4.4]
synonym: "NADPH-dependent GSH-cystine transhydrogenase" RELATED [EC:1.8.4.4]
xref: EC:1.8.4.4
xref: MetaCyc:1.8.4.4-RXN
xref: RHEA:12613
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047142
name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN]
synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" RELATED [EC:1.8.4.7]
synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT []
synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT []
synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" RELATED [EC:1.8.4.7]
synonym: "thiol:disulfide oxidoreductase activity" RELATED [EC:1.8.4.7]
synonym: "thiol:disulphide oxidoreductase activity" RELATED [EC:1.8.4.7]
synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" RELATED [EC:1.8.4.7]
synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" RELATED [EC:1.8.4.7]
xref: EC:1.8.4.7
xref: MetaCyc:1.8.4.7-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047143
name: chlorate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H2O + H+." [EC:1.97.1.1, RHEA:16349]
synonym: "chlorate reductase C" RELATED [EC:1.97.1.1]
synonym: "chlorite:acceptor oxidoreductase activity" RELATED [EC:1.97.1.1]
xref: EC:1.97.1.1
xref: KEGG_REACTION:R03575
xref: MetaCyc:1.97.1.1-RXN
xref: RHEA:16349
xref: UM-BBD_reactionID:r0981
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0047144
name: 2-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [GOC:ab, RHEA:14233]
synonym: "2-acylglycerophosphate acyltransferase activity" RELATED [EC:2.3.1.52]
synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" RELATED [EC:2.3.1.52]
xref: EC:2.3.1.52
xref: MetaCyc:2-ACYL2.3.1.15-RXN
xref: Reactome:R-HSA-1482533 "2-acyl LPC is acylated to PC by LPCAT"
xref: Reactome:R-HSA-1482546 "2-acyl LPG is acylated to PG by CRLS1 (IM)"
xref: Reactome:R-HSA-1482626 "2-acyl LPI is acylated to PI by MBOAT7"
xref: Reactome:R-HSA-1482635 "2-acyl LPG is acylated to PG by LPGAT"
xref: Reactome:R-HSA-1482646 "2-acyl LPE is acylated to PE by LPEAT"
xref: Reactome:R-HSA-1482691 "2-acyl LPS is acylated to PS by LPSAT"
xref: RHEA:14233
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity

[Term]
id: GO:0047145
name: demethylsterigmatocystin 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN]
synonym: "demethylsterigmatocystin methyltransferase activity" RELATED [EC:2.1.1.109]
synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109]
synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" RELATED [EC:2.1.1.109]
xref: EC:2.1.1.109
xref: MetaCyc:2.1.1.109-RXN
xref: RHEA:11504
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047146
name: sterigmatocystin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN]
synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110]
synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" RELATED [EC:2.1.1.110]
synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" RELATED [EC:2.1.1.110]
synonym: "sterigmatocystin 8-O-methyltransferase activity" RELATED [EC:2.1.1.110]
synonym: "sterigmatocystin methyltransferase activity" RELATED [EC:2.1.1.110]
xref: EC:2.1.1.110
xref: MetaCyc:2.1.1.110-RXN
xref: RHEA:15561
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047147
name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+." [EC:2.1.1.19, RHEA:13693]
synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.19]
synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" RELATED [EC:2.1.1.19]
synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT []
xref: EC:2.1.1.19
xref: KEGG_REACTION:R02573
xref: MetaCyc:2.1.1.19-RXN
xref: RHEA:13693
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0047148
name: methylamine-glutamate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH4." [EC:2.1.1.21, RHEA:15837]
synonym: "methylamine-glutamate methyltransferase activity" RELATED [EC:2.1.1.21]
synonym: "methylamine:L-glutamate N-methyltransferase activity" RELATED [EC:2.1.1.21]
synonym: "N-methylglutamate synthase activity" RELATED [EC:2.1.1.21]
xref: EC:2.1.1.21
xref: KEGG_REACTION:R01586
xref: MetaCyc:2.1.1.21-RXN
xref: RHEA:15837
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0047149
name: thetin-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H+." [EC:2.1.1.3, RHEA:22788]
synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.3]
synonym: "dimethylthetin-homocysteine methyltransferase activity" RELATED [EC:2.1.1.3]
synonym: "thetin-homocysteine methylpherase activity" RELATED [EC:2.1.1.3]
xref: EC:2.1.1.3
xref: KEGG_REACTION:R04153
xref: MetaCyc:2.1.1.3-RXN
xref: RHEA:22788
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0047150
name: betaine-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336]
synonym: "betaine-homocysteine methyltransferase activity" RELATED [EC:2.1.1.5]
synonym: "betaine-homocysteine transmethylase activity" RELATED [EC:2.1.1.5]
synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.5]
xref: EC:2.1.1.5
xref: KEGG_REACTION:R02821
xref: MetaCyc:2.1.1.5-RXN
xref: Reactome:R-HSA-1614654 "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY"
xref: RHEA:22336
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0047151
name: tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN]
synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" RELATED [EC:2.1.1.74]
synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" RELATED [EC:2.1.1.74]
synonym: "folate-dependent ribothymidyl synthase activity" RELATED [EC:2.1.1.74]
synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" RELATED [EC:2.1.1.74]
synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT []
synonym: "tRNA (uracil(54)-C(5))-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent" EXACT []
xref: EC:2.1.1.74
xref: KEGG_REACTION:R03704
xref: MetaCyc:2.1.1.74-RXN
xref: RHEA:16873
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity

[Term]
id: GO:0047152
name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity
namespace: molecular_function
alt_id: GO:1990087
def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [PMID:6438059, RHEA:45204]
comment: This function is the first step in the pathway of methanogenesis from methanol.
synonym: "methanol cobalamin methyltransferase activity" RELATED [EC:2.1.1.90]
synonym: "methanol-corrinoid protein Co-methyltransferase" EXACT []
synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" RELATED [EC:2.1.1.90]
synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" RELATED [EC:2.1.1.90]
synonym: "methanol:corrinoid methyltransferase activity" EXACT []
synonym: "methyltransferase 1" BROAD []
synonym: "MT 1" RELATED [EC:2.1.1.90]
synonym: "MT1" RELATED []
synonym: "MtaB" RELATED []
xref: EC:2.1.1.90
xref: MetaCyc:2.1.1.90-RXN
xref: RHEA:45204
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0047153
name: deoxycytidylate 5-hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, RHEA:11280]
synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" RELATED [EC:2.1.2.8]
synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" RELATED [EC:2.1.2.8]
synonym: "dCMP hydroxymethylase activity" RELATED [EC:2.1.2.8]
synonym: "deoxyCMP hydroxymethylase activity" RELATED [EC:2.1.2.8]
synonym: "deoxycytidylate hydroxymethylase activity" RELATED [EC:2.1.2.8]
synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT []
synonym: "deoxycytidylic hydroxymethylase activity" RELATED [EC:2.1.2.8]
xref: EC:2.1.2.8
xref: KEGG_REACTION:R01669
xref: MetaCyc:2.1.2.8-RXN
xref: RHEA:11280
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0047154
name: methylmalonyl-CoA carboxytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN]
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1]
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" RELATED [EC:2.1.3.1]
synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" RELATED [EC:2.1.3.1]
synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" RELATED [EC:2.1.3.1]
synonym: "methylmalonyl coenzyme A carboxyltransferase activity" RELATED [EC:2.1.3.1]
synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT []
synonym: "methylmalonyl-CoA transcarboxylase activity" RELATED [EC:2.1.3.1]
synonym: "oxalacetic transcarboxylase activity" RELATED [EC:2.1.3.1]
synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1]
xref: EC:2.1.3.1
xref: MetaCyc:2.1.3.1-RXN
xref: RHEA:20764
xref: UM-BBD_reactionID:r0923
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0047155
name: 3-hydroxymethylcephem carbamoyltransferase activity
namespace: molecular_function
alt_id: GO:0045447
def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN]
synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT []
synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" RELATED [EC:2.1.3.7]
xref: EC:2.1.3.7
xref: MetaCyc:2.1.3.7-RXN
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0047156
name: acetoin-ribose-5-phosphate transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [RHEA:21504]
synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" RELATED [EC:2.2.1.4]
synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" RELATED [EC:2.2.1.4]
synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" RELATED [EC:2.2.1.4]
synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" RELATED [EC:2.2.1.4]
xref: EC:2.2.1.4
xref: KEGG_REACTION:R02345
xref: MetaCyc:2.2.1.4-RXN
xref: RHEA:21504
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0047157
name: myelin-proteolipid O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [PMID:3818589]
synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" RELATED [EC:2.3.1.100]
synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100]
synonym: "myelin PLP acyltransferase activity" RELATED [EC:2.3.1.100]
synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" RELATED [EC:2.3.1.100]
xref: EC:2.3.1.100
xref: MetaCyc:2.3.1.100-RXN
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0047158
name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose." [EC:2.3.1.103, RHEA:22664]
synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.103]
synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" RELATED [EC:2.3.1.103]
synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.103]
xref: EC:2.3.1.103
xref: KEGG_REACTION:R00063
xref: MetaCyc:2.3.1.103-RXN
xref: RHEA:22664
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0047159
name: plasmalogen synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA." [RHEA:10344]
synonym: "1-alkenylglycerophosphocholine O-acyltransferase activity" RELATED []
synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.25]
xref: EC:2.3.1.25
xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN
xref: RHEA:10344
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047160
name: alkylglycerophosphate 2-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, RHEA:18557]
synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" RELATED [EC:2.3.1.105]
synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" RELATED [EC:2.3.1.105]
xref: EC:2.3.1.105
xref: KEGG_REACTION:R03455
xref: MetaCyc:2.3.1.105-RXN
xref: RHEA:18557
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047161
name: tartronate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate." [EC:2.3.1.106, RHEA:10952]
synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.106]
synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.106]
synonym: "tartronate sinapoyltransferase activity" RELATED [EC:2.3.1.106]
xref: EC:2.3.1.106
xref: KEGG_REACTION:R03965
xref: MetaCyc:2.3.1.106-RXN
xref: RHEA:10952
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047162
name: 17-O-deacetylvindoline O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA." [EC:2.3.1.107, RHEA:24496]
synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "DAT activity" RELATED [EC:2.3.1.107]
synonym: "deacetylvindoline acetyltransferase activity" RELATED [EC:2.3.1.107]
synonym: "deacetylvindoline O-acetyltransferase activity" RELATED [EC:2.3.1.107]
xref: EC:2.3.1.107
xref: KEGG_REACTION:R03230
xref: MetaCyc:2.3.1.107-RXN
xref: RHEA:24496
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047163
name: 3,4-dichloroaniline N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA." [EC:2.3.1.114, RHEA:21060]
synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" RELATED [EC:2.3.1.114]
xref: EC:2.3.1.114
xref: KEGG_REACTION:R04050
xref: MetaCyc:2.3.1.114-RXN
xref: RHEA:21060
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047164
name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115]
synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" RELATED [EC:2.3.1.115]
synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" RELATED [EC:2.3.1.115]
synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" RELATED [EC:2.3.1.115]
synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.115]
synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" RELATED [EC:2.3.1.115]
synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" RELATED [EC:2.3.1.115]
synonym: "MAT-7" RELATED [EC:2.3.1.115]
xref: EC:2.3.1.115
xref: MetaCyc:RXN-4703
xref: RHEA:15581
is_a: GO:0050736 ! O-malonyltransferase activity

[Term]
id: GO:0047165
name: flavonol-3-O-beta-glucoside O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN]
synonym: "flavonol 3-O-glucoside malonyltransferase activity" RELATED [EC:2.3.1.116]
synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.116]
synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" RELATED [EC:2.3.1.116]
synonym: "MAT-3" RELATED [EC:2.3.1.116]
xref: EC:2.3.1.116
xref: MetaCyc:2.3.1.116-RXN
xref: RHEA:20085
is_a: GO:0050736 ! O-malonyltransferase activity

[Term]
id: GO:0047166
name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN]
synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" RELATED [EC:2.3.1.121]
xref: EC:2.3.1.121
xref: MetaCyc:2.3.1.121-RXN
xref: RHEA:16245
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047167
name: 1-alkyl-2-acetylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN]
synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" RELATED [EC:2.3.1.125]
synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" RELATED [EC:2.3.1.125]
xref: EC:2.3.1.125
xref: MetaCyc:2.3.1.125-RXN
xref: RHEA:21996
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047168
name: isocitrate O-dihydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, RHEA:20756]
synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.126]
xref: EC:2.3.1.126
xref: KEGG_REACTION:R01946
xref: MetaCyc:2.3.1.126-RXN
xref: RHEA:20756
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047169
name: galactarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA." [EC:2.3.1.130, RHEA:12997]
synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.130]
synonym: "galacturate hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.130]
xref: EC:2.3.1.130
xref: KEGG_REACTION:R03727
xref: MetaCyc:2.3.1.130-RXN
xref: RHEA:12997
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047170
name: glucarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA." [EC:2.3.1.131, RHEA:23308]
synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.131]
xref: EC:2.3.1.131
xref: KEGG_REACTION:R02899
xref: MetaCyc:2.3.1.131-RXN
xref: RHEA:23308
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047171
name: glucarolactone O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN]
synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.132]
xref: EC:2.3.1.132
xref: MetaCyc:2.3.1.132-RXN
xref: RHEA:14261
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047172
name: shikimate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN]
synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.133]
synonym: "shikimate hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.133]
xref: EC:2.3.1.133
xref: MetaCyc:2.3.1.133-RXN
xref: RHEA:12124
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047173
name: phosphatidylcholine-retinol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form." [RHEA:17469]
synonym: "lecithin--retinol acyltransferase activity" RELATED [EC:2.3.1.135]
synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" RELATED [EC:2.3.1.135]
synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" RELATED [EC:2.3.1.135]
xref: EC:2.3.1.135
xref: MetaCyc:2.3.1.135-RXN
xref: Reactome:R-HSA-975608 "LRAT esterifies RBP2:atROL and FACYLs to atREs"
xref: RHEA:17469
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047174
name: putrescine N-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H+." [EC:2.3.1.138, RHEA:12436]
synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" RELATED [EC:2.3.1.138]
synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.138]
synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.138]
synonym: "PHT" RELATED [EC:2.3.1.138]
synonym: "putrescine hydroxycinnamoyl transferase activity" RELATED [EC:2.3.1.138]
synonym: "putrescine hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.138]
xref: EC:2.3.1.138
xref: KEGG_REACTION:R01944
xref: MetaCyc:2.3.1.138-RXN
xref: RHEA:12436
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0050734 ! hydroxycinnamoyltransferase activity

[Term]
id: GO:0047175
name: galactosylacylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN]
synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" RELATED [EC:2.3.1.141]
synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" RELATED [EC:2.3.1.141]
synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" RELATED [EC:2.3.1.141]
xref: EC:2.3.1.141
xref: MetaCyc:2.3.1.141-RXN
xref: RHEA:17057
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047176
name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.143, RHEA:19109]
synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" RELATED [EC:2.3.1.143]
synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" RELATED [EC:2.3.1.143]
synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" RELATED [EC:2.3.1.143]
synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" RELATED [EC:2.3.1.143]
xref: EC:2.3.1.143
xref: KEGG_REACTION:R04498
xref: MetaCyc:2.3.1.143-RXN
xref: RHEA:19109
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047177
name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN]
synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" RELATED [EC:2.3.1.147]
synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" RELATED [EC:2.3.1.147]
xref: EC:2.3.1.147
xref: MetaCyc:2.3.1.147-RXN
xref: RHEA:15409
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047178
name: glycerophospholipid acyltransferase (CoA-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN]
synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" RELATED [EC:2.3.1.148]
xref: EC:2.3.1.148
xref: MetaCyc:2.3.1.148-RXN
xref: RHEA:20972
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047179
name: platelet-activating factor acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN]
synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" RELATED [EC:2.3.1.149]
synonym: "PAF acetyltransferase activity" EXACT []
xref: EC:2.3.1.149
xref: MetaCyc:2.3.1.149-RXN
xref: RHEA:11048
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0047180
name: salutaridinol 7-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, RHEA:22856]
synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" RELATED [EC:2.3.1.150]
xref: EC:2.3.1.150
xref: KEGG_REACTION:R04723
xref: MetaCyc:2.3.1.150-RXN
xref: RHEA:22856
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047181
name: tetrahydroxybenzophenone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN]
synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" RELATED [EC:2.3.1.151]
xref: EC:2.3.1.151
xref: MetaCyc:2.3.1.151-RXN
xref: RHEA:19305
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047182
name: alcohol O-cinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN]
synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" RELATED [EC:2.3.1.152]
xref: EC:2.3.1.152
xref: MetaCyc:2.3.1.152-RXN
xref: RHEA:23524
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047183
name: anthocyanin 5-(6'''-hydroxycinnamoyltransferase) activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA. Caffeoyl-CoA can also act as an acyl donor." [EC:2.3.1.153, RHEA:15661]
synonym: "anthocyanin 5-aromatic acyltransferase activity" EXACT []
synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.153]
xref: EC:2.3.1.153
xref: MetaCyc:RXN-7945
xref: RHEA:15661
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047184
name: 1-acylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0000507
def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]
synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" RELATED [EC:2.3.1.23]
synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" RELATED [EC:2.3.1.23]
synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" RELATED [EC:2.3.1.23]
synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.23]
synonym: "lysolecithin acyltransferase activity" RELATED [EC:2.3.1.23]
synonym: "lysophosphatide acyltransferase activity" RELATED [EC:2.3.1.23]
synonym: "lysophosphatidylcholine acyltransferase activity" RELATED [EC:2.3.1.23]
xref: EC:2.3.1.23
xref: MetaCyc:2.3.1.23-RXN
xref: Reactome:R-HSA-1482794 "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)"
xref: RHEA:12937
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047185
name: N-acetylneuraminate 4-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, RHEA:18305]
synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" RELATED [EC:2.3.1.44]
synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44]
xref: EC:2.3.1.44
xref: KEGG_REACTION:R01806
xref: MetaCyc:2.3.1.44-RXN
xref: RHEA:18305
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047186
name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN]
synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "glycoprotein 7(9)-O-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" RELATED [EC:2.3.1.45]
synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45]
xref: EC:2.3.1.45
xref: MetaCyc:2.3.1.45-RXN
xref: RHEA:20808
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047187
name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN]
synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" RELATED [EC:2.3.1.49]
synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" RELATED [EC:2.3.1.49]
synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" RELATED [EC:2.3.1.49]
synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" RELATED [EC:2.3.1.49]
xref: EC:2.3.1.49
xref: MetaCyc:2.3.1.49-RXN
xref: RHEA:20393
is_a: GO:0016418 ! S-acetyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0047188
name: aromatic-hydroxylamine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN]
synonym: "aromatic hydroxylamine acetyltransferase activity" RELATED [EC:2.3.1.56]
synonym: "arylhydroxamate acyltransferase activity" RELATED [EC:2.3.1.56]
synonym: "arylhydroxamic acid N,O-acetyltransferase activity" RELATED [EC:2.3.1.56]
synonym: "arylhydroxamic acyltransferase activity" RELATED [EC:2.3.1.56]
synonym: "N,O-acetyltransferase activity" RELATED [EC:2.3.1.56]
synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" RELATED [EC:2.3.1.56]
synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" RELATED [EC:2.3.1.56]
xref: EC:2.3.1.56
xref: MetaCyc:2.3.1.56-RXN
xref: RHEA:20325
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047189
name: 2,3-diaminopropionate N-oxalyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA." [RHEA:13465]
synonym: "ODAP synthase activity" RELATED [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" RELATED [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" RELATED [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" RELATED [EC:2.3.1.58]
synonym: "oxalyldiaminopropionate synthase activity" RELATED [EC:2.3.1.58]
synonym: "oxalyldiaminopropionic synthase activity" RELATED [EC:2.3.1.58]
xref: EC:2.3.1.58
xref: KEGG_REACTION:R04211
xref: MetaCyc:2.3.1.58-RXN
xref: RHEA:13465
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047190
name: 2-acylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA." [RHEA:10332]
synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" RELATED [EC:2.3.1.62]
synonym: "2-acylglycerophosphocholine acyltransferase activity" RELATED [EC:2.3.1.62]
synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.62]
xref: EC:2.3.1.62
xref: KEGG_REACTION:R01319
xref: MetaCyc:2.3.1.62-RXN
xref: RHEA:10332
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047191
name: 1-alkylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN]
synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.63]
xref: EC:2.3.1.63
xref: MetaCyc:2.3.1.63-RXN
xref: RHEA:23992
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047192
name: 1-alkylglycerophosphocholine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN]
synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" RELATED [EC:2.3.1.67]
synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" RELATED [EC:2.3.1.67]
synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" RELATED [EC:2.3.1.67]
synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" RELATED [EC:2.3.1.67]
synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" RELATED [EC:2.3.1.67]
synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" RELATED [EC:2.3.1.67]
synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67]
synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67]
xref: EC:2.3.1.67
xref: MetaCyc:2.3.1.67-RXN
xref: RHEA:18461
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047193
name: obsolete CDP-acylglycerol O-arachidonoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN]
comment: This term was made obsolete because the evidence for the existence of this reaction was retracted. Please see PMID:6885763 for more information.
synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" RELATED [EC:2.3.1.70]
synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" RELATED [EC:2.3.1.70]
synonym: "CDP-acylglycerol O-arachidonoyltransferase activity" EXACT []
synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT []
synonym: "CDPacylglycerol O-arachidonyltransferase activity" RELATED [EC:2.3.1.70]
is_obsolete: true

[Term]
id: GO:0047194
name: indoleacetylglucose-inositol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose." [EC:2.3.1.72, RHEA:21180]
synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" RELATED [EC:2.3.1.72]
synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" RELATED [EC:2.3.1.72]
synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" RELATED [EC:2.3.1.72]
xref: EC:2.3.1.72
xref: KEGG_REACTION:R04333
xref: MetaCyc:2.3.1.72-RXN
xref: RHEA:21180
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047195
name: diacylglycerol-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN]
synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" RELATED [EC:2.3.1.73]
synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" RELATED [EC:2.3.1.73]
xref: EC:2.3.1.73
xref: MetaCyc:2.3.1.73-RXN
xref: RHEA:13301
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047196
name: long-chain-alcohol O-fatty-acyltransferase activity
namespace: molecular_function
alt_id: GO:0103095
def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN]
synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" RELATED [EC:2.3.1.75]
synonym: "wax ester synthase activity" EXACT []
synonym: "wax synthase activity" RELATED [EC:2.3.1.75]
synonym: "wax-ester synthase activity" RELATED [EC:2.3.1.75]
xref: EC:2.3.1.75
xref: MetaCyc:2.3.1.75-RXN
xref: Reactome:R-HSA-5696424 "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters"
xref: Reactome:R-HSA-8848582 "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester"
xref: RHEA:38443
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047197
name: triglyceride-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN]
synonym: "triacylglycerol-sterol O-acyltransferase activity" EXACT []
synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" RELATED [EC:2.3.1.77]
synonym: "triacylglycerol:sterol acyltransferase activity" RELATED [EC:2.3.1.77]
xref: EC:2.3.1.77
xref: MetaCyc:2.3.1.77-RXN
xref: RHEA:16897
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047198
name: cysteine-S-conjugate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+." [EC:2.3.1.80, RHEA:19213]
synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" RELATED [EC:2.3.1.80]
xref: EC:2.3.1.80
xref: KEGG_REACTION:R04950
xref: MetaCyc:2.3.1.80-RXN
xref: Reactome:R-HSA-5433066 "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C"
xref: RHEA:19213
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047199
name: phosphatidylcholine-dolichol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol." [EC:2.3.1.83, RHEA:19285]
synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" RELATED [EC:2.3.1.83]
xref: EC:2.3.1.83
xref: KEGG_REACTION:R04227
xref: MetaCyc:2.3.1.83-RXN
xref: RHEA:19285
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047200
name: tetrahydrodipicolinate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA." [EC:2.3.1.89, RHEA:13085]
synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" RELATED [EC:2.3.1.89]
synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" RELATED [EC:2.3.1.89]
synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" RELATED [EC:2.3.1.89]
synonym: "tetrahydrodipicolinate acetylase activity" RELATED [EC:2.3.1.89]
synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" RELATED [EC:2.3.1.89]
xref: EC:2.3.1.89
xref: KEGG_REACTION:R04364
xref: MetaCyc:2.3.1.89-RXN
xref: RHEA:13085
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047201
name: beta-glucogallin O-galloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.90, RHEA:11416]
synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" RELATED [EC:2.3.1.90]
xref: EC:2.3.1.90
xref: KEGG_REACTION:R00049
xref: MetaCyc:2.3.1.90-RXN
xref: RHEA:11416
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047202
name: sinapoylglucose-choline O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose." [EC:2.3.1.91, RHEA:12024]
synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" RELATED [EC:2.3.1.91]
synonym: "sinapine synthase activity" RELATED [EC:2.3.1.91]
xref: EC:2.3.1.91
xref: KEGG_REACTION:R03075
xref: MetaCyc:2.3.1.91-RXN
xref: RHEA:12024
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0047203
name: 13-hydroxylupinine O-tigloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA." [RHEA:12360]
synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" RELATED [EC:2.3.1.93]
synonym: "13-hydroxylupanine acyltransferase activity" RELATED [EC:2.3.1.93]
synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" RELATED [EC:2.3.1.93]
xref: EC:2.3.1.93
xref: KEGG_REACTION:R04205
xref: MetaCyc:RXN-8694
xref: RHEA:12360
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047204
name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate." [EC:2.3.1.98, RHEA:23204]
synonym: "chlorogenate:glucarate caffeoyltransferase activity" RELATED [EC:2.3.1.98]
synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.98]
synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" RELATED [EC:2.3.1.98]
xref: EC:2.3.1.98
xref: KEGG_REACTION:R02998
xref: MetaCyc:2.3.1.98-RXN
xref: RHEA:23204
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047205
name: quinate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN]
synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.99]
synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" RELATED [EC:2.3.1.99]
xref: EC:2.3.1.99
xref: MetaCyc:2.3.1.99-RXN
xref: RHEA:15021
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047206
name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA(Ala) = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA(Ala)." [EC:2.3.2.10]
synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" EXACT [EC:2.3.2.10]
synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
xref: EC:2.3.2.10
xref: MetaCyc:2.3.2.10-RXN
xref: RHEA:12432
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0047207
name: 1,2-beta-fructan 1F-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN]
synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" RELATED [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" RELATED [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.100]
synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" RELATED [EC:2.4.1.100]
synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.100]
synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" RELATED [EC:2.4.1.100]
synonym: "FFT activity" RELATED [EC:2.4.1.100]
synonym: "fructan:fructan fructosyl transferase activity" RELATED [EC:2.4.1.100]
xref: EC:2.4.1.100
xref: MetaCyc:2.4.1.100-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0047208
name: o-dihydroxycoumarin 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H+ + UDP." [EC:2.4.1.104, RHEA:14325]
synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.104]
synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" RELATED [EC:2.4.1.104]
synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.104]
synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.104]
xref: EC:2.4.1.104
xref: KEGG_REACTION:R03548
xref: MetaCyc:2.4.1.104-RXN
xref: RHEA:14325
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047209
name: coniferyl-alcohol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN]
synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" RELATED [EC:2.4.1.111]
synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.111]
synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.111]
synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" RELATED [EC:2.4.1.111]
xref: EC:2.4.1.111
xref: MetaCyc:2.4.1.111-RXN
xref: RHEA:23944
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047211
name: alpha-1,4-glucan-protein synthase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN]
synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT []
synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" RELATED [EC:2.4.1.113]
synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.113]
synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.113]
synonym: "ADPglucose:protein glucosyltransferase activity" RELATED [EC:2.4.1.113]
xref: EC:2.4.1.113
xref: MetaCyc:2.4.1.113-RXN
is_a: GO:0016758 ! hexosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0047212
name: 2-coumarate O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H+ + UDP." [EC:2.4.1.114, RHEA:10236]
synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.114]
synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" RELATED [EC:2.4.1.114]
synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.114]
synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" RELATED [EC:2.4.1.114]
xref: EC:2.4.1.114
xref: KEGG_REACTION:R03710
xref: MetaCyc:2.4.1.114-RXN
xref: RHEA:10236
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047213
name: anthocyanidin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN]
synonym: "3-GT activity" RELATED [EC:2.4.1.115]
synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.115]
synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.115]
synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.115]
synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" RELATED [EC:2.4.1.115]
synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.115]
xref: EC:2.4.1.115
xref: MetaCyc:2.4.1.115-RXN
xref: RHEA:20093
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047214
name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN]
synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" RELATED [EC:2.4.1.116]
synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.116]
synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.116]
synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" RELATED [EC:2.4.1.116]
xref: EC:2.4.1.116
xref: MetaCyc:2.4.1.116-RXN
xref: RHEA:12144
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047215
name: indole-3-acetate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP." [EC:2.4.1.121, RHEA:14921]
synonym: "IAA-Glu synthetase activity" RELATED [EC:2.4.1.121]
synonym: "IAA-glucose synthase activity" RELATED [EC:2.4.1.121]
synonym: "IAGlu synthase activity" RELATED [EC:2.4.1.121]
synonym: "indol-3-ylacetylglucose synthase activity" RELATED [EC:2.4.1.121]
synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.121]
synonym: "UDP-glucose:auxin glucosyltransferase activity" BROAD []
synonym: "UDP-glucose:indol-3-acetic acid glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" RELATED [EC:2.4.1.121]
synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" RELATED [EC:2.4.1.121]
synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" RELATED [EC:2.4.1.121]
synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.121]
synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" RELATED [EC:2.4.1.121]
xref: EC:2.4.1.121
xref: KEGG_REACTION:R03094
xref: MetaCyc:2.4.1.121-RXN
xref: RHEA:14921
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047216
name: inositol 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN]
synonym: "galactinol synthase activity" RELATED [EC:2.4.1.123]
synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT []
synonym: "UDP-D-galactose:inositol galactosyltransferase activity" RELATED [EC:2.4.1.123]
synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.123]
synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.123]
synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.123]
synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" RELATED [EC:2.4.1.123]
xref: EC:2.4.1.123
xref: MetaCyc:2.4.1.123-RXN
xref: RHEA:12464
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047217
name: obsolete sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as dextransucrase activity ; GO:0047849.
is_obsolete: true
replaced_by: GO:0047849

[Term]
id: GO:0047218
name: hydroxycinnamate 4-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP. Also acts on ferulate, caffeate and sinapate, forming a mixture of 4-glucosides and glucose esters." [EC:2.4.1.126]
synonym: "hydroxycinnamoyl glucosyltransferase activity" RELATED [EC:2.4.1.126]
synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" RELATED [EC:2.4.1.126]
synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.126]
synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.126]
synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" RELATED [EC:2.4.1.126]
xref: EC:2.4.1.126
xref: MetaCyc:2.4.1.126-RXN
xref: RHEA:21636
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047219
name: monoterpenol beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H+ + UDP." [EC:2.4.1.127, RHEA:11520]
synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.127]
synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.127]
synonym: "UDPglucose:monoterpenol glucosyltransferase activity" RELATED [EC:2.4.1.127]
synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" RELATED [EC:2.4.1.127]
xref: EC:2.4.1.127
xref: KEGG_REACTION:R02179
xref: MetaCyc:2.4.1.127-RXN
xref: RHEA:11520
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047220
name: galactosylxylosylprotein 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN]
synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134]
synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.134]
synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.134]
synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" RELATED [EC:2.4.1.134]
xref: EC:2.4.1.134
xref: MetaCyc:2.4.1.134-RXN
xref: Reactome:R-HSA-1889978 "B3GALT6 transfers Gal to the tetrasaccharide linker"
xref: Reactome:R-HSA-4420365 "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker"
xref: RHEA:11780
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0047221
name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H+ + UDP." [EC:2.4.1.137, RHEA:14285]
synonym: "floridoside phosphate synthase activity" RELATED [EC:2.4.1.137]
synonym: "floridoside phosphate synthetase activity" RELATED [EC:2.4.1.137]
synonym: "floridoside-phosphate synthase activity" RELATED [EC:2.4.1.137]
synonym: "FPS" RELATED [EC:2.4.1.137]
synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" RELATED [EC:2.4.1.137]
synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.137]
synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" RELATED [EC:2.4.1.137]
synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.137]
xref: EC:2.4.1.137
xref: KEGG_REACTION:R00853
xref: MetaCyc:2.4.1.137-RXN
xref: RHEA:14285
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047222
name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN]
synonym: "alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.138]
synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.138]
synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" RELATED [EC:2.4.1.138]
xref: EC:2.4.1.138
xref: MetaCyc:2.4.1.138-RXN
xref: RHEA:13705
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047223
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN]
synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146]
synonym: "elongation 3beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.146]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.146]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" RELATED [EC:2.4.1.146]
xref: EC:2.4.1.146
xref: MetaCyc:2.4.1.146-RXN
xref: Reactome:R-HSA-5617037 "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1"
xref: Reactome:R-HSA-5617096 "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1"
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0047224
name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-O-N-acetyl-D-galactosalaminyl-[protein] + UDP-N-acetyl-D-glucosamine = 3-O-N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-[protein] + UDP. Linkage of the glycan to the protein occurs via the oxygen atom in the side chain of an L-serine or L-threonine residue." [EC:2.4.1.147]
synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147]
synonym: "core 3beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147]
synonym: "mucin core 3 beta3-GlcNAc-transferase activity" RELATED [EC:2.4.1.147]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.147]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.147]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.147]
xref: EC:2.4.1.147
xref: MetaCyc:2.4.1.147-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0047225
name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148]
synonym: "core 4 beta6-GalNAc-transferase activity" RELATED [EC:2.4.1.148]
synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148]
synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.148]
synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.148]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148]
xref: EC:2.4.1.148
xref: MetaCyc:2.4.1.148-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0047227
name: indolylacetyl-myo-inositol galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H+ + UDP." [EC:2.4.1.156, RHEA:21148]
synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" RELATED [EC:2.4.1.156]
synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" RELATED [EC:2.4.1.156]
synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" RELATED [EC:2.4.1.156]
synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" RELATED [EC:2.4.1.156]
xref: EC:2.4.1.156
xref: KEGG_REACTION:R04334
xref: MetaCyc:2.4.1.156-RXN
xref: RHEA:21148
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047228
name: 1,2-diacylglycerol 3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H+ + UDP." [RHEA:47612]
synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.337]
synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" RELATED [EC:2.4.1.337]
synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.337]
synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" RELATED [EC:2.4.1.337]
synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.337]
synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.337]
xref: EC:2.4.1.337
xref: MetaCyc:2.4.1.157-RXN
xref: RHEA:47612
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047229
name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158]
synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" RELATED [EC:2.4.1.158]
synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" RELATED [EC:2.4.1.158]
synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.158]
synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" RELATED [EC:2.4.1.158]
synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.158]
synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" RELATED [EC:2.4.1.158]
xref: EC:2.4.1.158
xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN
xref: RHEA:22316
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047230
name: flavonol-3-O-glucoside L-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN]
synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" RELATED [EC:2.4.1.159]
synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" RELATED [EC:2.4.1.159]
synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" RELATED [EC:2.4.1.159]
xref: EC:2.4.1.159
xref: MetaCyc:2.4.1.159-RXN
xref: RHEA:22528
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047231
name: pyridoxine 5'-O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H+ + UDP." [EC:2.4.1.160, RHEA:20177]
synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" RELATED [EC:2.4.1.160]
synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.160]
synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" RELATED [EC:2.4.1.160]
synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.160]
synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" RELATED [EC:2.4.1.160]
xref: EC:2.4.1.160
xref: KEGG_REACTION:R01912
xref: MetaCyc:2.4.1.160-RXN
xref: RHEA:20177
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047232
name: obsolete galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [GOC:curators]
comment: The reason for obsoletion is that this term is equivalent to GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity.
synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.164]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164]
is_obsolete: true
replaced_by: GO:0008109

[Term]
id: GO:0047233
name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.165]
synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.165]
xref: EC:2.4.1.165
xref: MetaCyc:2.4.1.165-RXN
xref: RHEA:13569
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047234
name: raffinose-raffinose alpha-galactotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166]
synonym: "raffinose (raffinose donor) galactosyltransferase activity" RELATED [EC:2.4.1.166]
synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT []
synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT []
synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.166]
synonym: "raffinose:raffinose alpha-galactosyltransferase activity" RELATED [EC:2.4.1.166]
xref: EC:2.4.1.166
xref: MetaCyc:RXN-11490
xref: RHEA:14125
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047235
name: sucrose 6F-alpha-galactotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN]
synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT []
synonym: "sucrose 6F-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.167]
synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.167]
synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.167]
synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.167]
synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.167]
xref: EC:2.4.1.167
xref: MetaCyc:2.4.1.167-RXN
xref: RHEA:10088
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047236
name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN]
synonym: "cycasin synthase activity" RELATED [EC:2.4.1.171]
synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.171]
synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" RELATED [EC:2.4.1.171]
synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" RELATED [EC:2.4.1.171]
xref: EC:2.4.1.171
xref: MetaCyc:2.4.1.171-RXN
xref: RHEA:20205
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047237
name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN]
synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "N-acetylgalactosaminyltransferase I activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.174]
synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174]
synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" RELATED [EC:2.4.1.174]
xref: EC:2.4.1.174
xref: MetaCyc:2.4.1.174-RXN
xref: RHEA:23464
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047238
name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175]
synonym: "chondroitin synthase activity" RELATED [EC:2.4.1.175]
synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "N-acetylgalactosaminyltransferase II activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.175]
synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.175]
synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" RELATED [EC:2.4.1.175]
xref: EC:2.4.1.175
xref: MetaCyc:RXN-16325
xref: Reactome:R-HSA-1971482 "The addition of GalNAc to the terminal glucuronate residue forms chondroitin"
xref: Reactome:R-HSA-1971487 "CHPF,CHSY3 transfer GalNAc to chondroitin"
xref: Reactome:R-HSA-3595176 "Defective CHSY1 does not transfer GalNAc to chondroitin"
xref: Reactome:R-HSA-9632033 "CHSY1 transfers GalNAc to chondroitin"
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047239
name: hydroxymandelonitrile glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H+ + taxiphyllin + UDP." [EC:2.4.1.178, RHEA:15961]
synonym: "cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.178]
synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.178]
synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.178]
xref: EC:2.4.1.178
xref: KEGG_REACTION:R02709
xref: MetaCyc:2.4.1.178-RXN
xref: RHEA:15961
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047240
name: lactosylceramide beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H+ + UDP." [EC:2.4.1.179, RHEA:18413]
synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.179]
synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.179]
synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" RELATED [EC:2.4.1.179]
xref: EC:2.4.1.179
xref: KEGG_REACTION:R04431
xref: MetaCyc:2.4.1.179-RXN
xref: RHEA:18413
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0047241
name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [RHEA:28366]
synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT []
synonym: "ManNAcA transferase activity" RELATED [EC:2.4.1.180]
synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" RELATED [EC:2.4.1.180]
synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" RELATED [EC:2.4.1.180]
xref: EC:2.4.1.180
xref: MetaCyc:UDPMANACATRANS-RXN
xref: RHEA:28366
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity
is_a: GO:0008194 ! UDP-glycosyltransferase activity

[Term]
id: GO:0047242
name: hydroxyanthraquinone glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181]
synonym: "anthraquinone-specific glucosyltransferase activity" RELATED [EC:2.4.1.181]
synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" RELATED [EC:2.4.1.181]
synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" RELATED [EC:2.4.1.181]
synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" RELATED [EC:2.4.1.181]
xref: EC:2.4.1.181
xref: MetaCyc:2.4.1.181-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047243
name: flavanone 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN]
synonym: "hesperetin 7-O-glucosyl-transferase activity" RELATED [EC:2.4.1.185]
synonym: "naringenin 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.185]
synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.185]
synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.185]
synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.185]
xref: EC:2.4.1.185
xref: MetaCyc:2.4.1.185-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047244
name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187]
synonym: "N-acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187]
synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187]
synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187]
synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187]
xref: EC:2.4.1.187
xref: MetaCyc:TEICHOICSYN2-RXN
xref: RHEA:16053
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047245
name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN]
synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" RELATED [EC:2.4.1.188]
synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.188]
synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.188]
synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" RELATED [EC:2.4.1.188]
xref: EC:2.4.1.188
xref: MetaCyc:2.4.1.188-RXN
xref: RHEA:20952
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047246
name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP." [EC:2.4.1.190, RHEA:14149]
synonym: "LMT activity" RELATED [EC:2.4.1.190]
synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.190]
synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" RELATED [EC:2.4.1.190]
synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.190]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" RELATED [EC:2.4.1.190]
xref: EC:2.4.1.190
xref: KEGG_REACTION:R06827
xref: MetaCyc:2.4.1.190-RXN
xref: RHEA:14149
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047247
name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.191, RHEA:22116]
synonym: "LDT" RELATED [EC:2.4.1.191]
synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" RELATED [EC:2.4.1.191]
synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.191]
synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" RELATED [EC:2.4.1.191]
synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.191]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" RELATED [EC:2.4.1.191]
xref: EC:2.4.1.191
xref: KEGG_REACTION:R06828
xref: MetaCyc:2.4.1.191-RXN
xref: RHEA:22116
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047248
name: nuatigenin 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nuatigenin + UDP-D-glucose = H+ + nuatigenin 3-beta-D-glucopyranoside + UDP." [EC:2.4.1.192, RHEA:19329]
synonym: "nuatigenin 3beta-glucosyltransferase activity" RELATED [EC:2.4.1.192]
synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.192]
synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.192]
synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" RELATED [EC:2.4.1.192]
xref: EC:2.4.1.192
xref: KEGG_REACTION:R04577
xref: MetaCyc:2.4.1.192-RXN
xref: RHEA:19329
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047249
name: sarsapogenin 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H+ + UDP." [EC:2.4.1.193, RHEA:14461]
synonym: "sarsapogenin 3beta-glucosyltransferase activity" RELATED [EC:2.4.1.193]
synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.193]
synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.193]
synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" RELATED [EC:2.4.1.193]
xref: EC:2.4.1.193
xref: KEGG_REACTION:R04359
xref: MetaCyc:2.4.1.193-RXN
xref: RHEA:14461
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047250
name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H+ + UDP." [EC:2.4.1.194, RHEA:15153]
synonym: "HBA glucosyltransferase activity" RELATED [EC:2.4.1.194]
synonym: "p-hydroxybenzoate glucosyltransferase activity" RELATED [EC:2.4.1.194]
synonym: "PHB glucosyltransferase activity" RELATED [EC:2.4.1.194]
synonym: "PHB-O-glucosyltransferase activity" RELATED [EC:2.4.1.194]
synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" RELATED [EC:2.4.1.194]
synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.194]
synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.194]
synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" RELATED [EC:2.4.1.194]
xref: EC:2.4.1.194
xref: KEGG_REACTION:R01304
xref: MetaCyc:2.4.1.194-RXN
xref: RHEA:15153
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047251
name: thiohydroximate beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195]
synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.195]
synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" RELATED [EC:2.4.1.195]
synonym: "thiohydroximate glucosyltransferase activity" RELATED [EC:2.4.1.195]
synonym: "thiohydroximate S-glucosyltransferase activity" RELATED [EC:2.4.1.195]
synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.195]
synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.195]
synonym: "UDPG:thiohydroximate glucosyltransferase activity" RELATED [EC:2.4.1.195]
synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" RELATED [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:2.4.1.195-RXN
xref: RHEA:13757
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047252
name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN]
synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.199]
synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" RELATED [EC:2.4.1.199]
xref: EC:2.4.1.199
xref: MetaCyc:2.4.1.199-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047253
name: alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN]
synonym: "alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT []
synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.201]
synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201]
synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.201]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201]
xref: EC:2.4.1.201
xref: MetaCyc:2.4.1.201-RXN
xref: RHEA:19945
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0047254
name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202]
synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" RELATED [EC:2.4.1.202]
synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" RELATED [EC:2.4.1.202]
synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" RELATED [EC:2.4.1.202]
xref: EC:2.4.1.202
xref: MetaCyc:RXN-7022
xref: RHEA:15541
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047255
name: galactogen 6-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN]
synonym: "1,6-D-galactosyltransferase activity" RELATED [EC:2.4.1.205]
synonym: "beta-(1,6)-D-galactosyltransferase activity" RELATED [EC:2.4.1.205]
synonym: "galactogen 6beta-galactosyltransferase activity" RELATED [EC:2.4.1.205]
synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" RELATED [EC:2.4.1.205]
synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" RELATED [EC:2.4.1.205]
synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" RELATED [EC:2.4.1.205]
xref: EC:2.4.1.205
xref: MetaCyc:2.4.1.205-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047256
name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H+ + UDP." [RHEA:13905]
synonym: "beta1->3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206]
synonym: "LA2 synthase activity" RELATED [EC:2.4.1.206]
synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206]
synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206]
synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206]
xref: EC:2.4.1.206
xref: MetaCyc:2.4.1.206-RXN
xref: Reactome:R-HSA-9846501 "B3GNT5 transfers GlcNAc to LacCer"
xref: RHEA:13905
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047257
name: diglucosyl diacylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN]
synonym: "DGlcDAG synthase activity" RELATED [EC:2.4.1.208]
synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT []
synonym: "MGlcDAG (1->2) glucosyltransferase activity" RELATED [EC:2.4.1.208]
synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" RELATED [EC:2.4.1.208]
synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" RELATED [EC:2.4.1.208]
xref: EC:2.4.1.208
xref: MetaCyc:2.4.1.208-RXN
xref: RHEA:19165
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047258
name: sphingosine beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine + UDP-D-galactose = H+ + psychosine + UDP." [EC:2.4.1.23, RHEA:19485]
synonym: "galactosyl-sphingosine transferase activity" RELATED [EC:2.4.1.23]
synonym: "psychosine-UDP galactosyltransferase activity" RELATED [EC:2.4.1.23]
synonym: "psychosine-uridine diphosphate galactosyltransferase activity" RELATED [EC:2.4.1.23]
synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" RELATED [EC:2.4.1.23]
synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" RELATED [EC:2.4.1.23]
synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" RELATED [EC:2.4.1.23]
synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" RELATED [EC:2.4.1.23]
xref: EC:2.4.1.23
xref: KEGG_REACTION:R01928
xref: MetaCyc:2.4.1.23-RXN
xref: RHEA:19485
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047259
name: glucomannan 4-beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN]
synonym: "GDP-man-beta-mannan mannosyltransferase activity" RELATED [EC:2.4.1.32]
synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT []
synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT []
synonym: "glucomannan-synthase activity" EXACT []
xref: EC:2.4.1.32
xref: MetaCyc:2.4.1.32-RXN
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0047260
name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN]
synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" RELATED [EC:2.4.1.36]
synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.36]
synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.36]
synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.36]
synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" RELATED [EC:2.4.1.36]
synonym: "trehalose phosphate synthase (GDP-forming) activity" RELATED [EC:2.4.1.36]
xref: EC:2.4.1.36
xref: MetaCyc:2.4.1.36-RXN
xref: RHEA:14605
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047261
name: steroid N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H+ + UDP." [EC:2.4.1.39, RHEA:14153]
synonym: "hydroxy steroid acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39]
synonym: "steroid acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39]
synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39]
synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39]
xref: EC:2.4.1.39
xref: KEGG_REACTION:R04451
xref: MetaCyc:2.4.1.39-RXN
xref: RHEA:14153
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047262
name: polygalacturonate 4-alpha-galacturonosyltransferase activity
namespace: molecular_function
alt_id: GO:0050375
def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN]
synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" RELATED [EC:2.4.1.43]
synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" RELATED [EC:2.4.1.43]
synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" RELATED [EC:2.4.1.43]
xref: EC:2.4.1.43
xref: MetaCyc:2.4.1.43-RXN
xref: RHEA:13573
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047263
name: obsolete N-acylsphingosine galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [GOC:curator]
comment: The reason for obsoletion is that this term is equivalent to GO:0003851.
is_obsolete: true
replaced_by: GO:0003851

[Term]
id: GO:0047264
name: heteroglycan alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP. 1,2- and 1,3-mannosyl bonds are formed." [EC:2.4.1.48]
synonym: "GDP mannose alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48]
synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.48]
synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48]
synonym: "heteropolysaccharide alpha-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.48
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047265
name: poly(glycerol-phosphate) alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52]
synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" RELATED [EC:2.4.1.52]
synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.52]
synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.52]
synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" RELATED [EC:2.4.1.52]
xref: EC:2.4.1.52
xref: MetaCyc:TEICHOICSYN5-RXN
xref: RHEA:15845
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047266
name: poly(ribitol-phosphate) beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53]
synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" RELATED [EC:2.4.1.53]
synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" RELATED [EC:2.4.1.53]
synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" RELATED [EC:2.4.1.53]
synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.53]
synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.53]
synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" RELATED [EC:2.4.1.53]
xref: EC:2.4.1.53
xref: MetaCyc:RXN-18017
xref: RHEA:10068
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047267
name: undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol." [EC:2.4.1.54]
synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" RELATED [EC:2.4.1.54]
synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" RELATED [EC:2.4.1.54]
synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" RELATED [EC:2.4.1.54]
synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" RELATED [EC:2.4.1.54]
xref: EC:2.4.1.54
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047268
name: galactinol-raffinose galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN]
synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" RELATED [EC:2.4.1.67]
synonym: "stachyose synthetase activity" RELATED [EC:2.4.1.67]
xref: EC:2.4.1.67
xref: MetaCyc:2.4.1.67-RXN
xref: RHEA:20776
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047269
name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70]
synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.70]
synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.70]
synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.70]
xref: EC:2.4.1.70
xref: MetaCyc:2.4.1.53-RXN
xref: RHEA:21012
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047270
name: lipopolysaccharide glucosyltransferase II activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + alpha-D-glucosyl-lipopolysaccharide." [EC:2.4.1.73]
synonym: "LPS glucosyltransferase II activity" EXACT []
synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.73]
synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.73]
synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.73]
xref: EC:2.4.1.73
xref: MetaCyc:RXN0-5125
xref: RHEA:30003
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047271
name: glycosaminoglycan galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN]
synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" RELATED [EC:2.4.1.74]
synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" RELATED [EC:2.4.1.74]
synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" RELATED [EC:2.4.1.74]
xref: EC:2.4.1.74
xref: MetaCyc:2.4.1.74-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047272
name: phosphopolyprenol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN]
synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" RELATED [EC:2.4.1.78]
synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" RELATED [EC:2.4.1.78]
synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" RELATED [EC:2.4.1.78]
synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" RELATED [EC:2.4.1.78]
xref: EC:2.4.1.78
xref: MetaCyc:2.4.1.78-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047273
name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0047226
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN]
synonym: "beta-3GalNAc-T1 activity" RELATED [EC:2.4.1.79]
synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79]
synonym: "galactosylgalactosylglucosylceramide beta-D- activity" RELATED [EC:2.4.1.79]
synonym: "globoside synthase activity" RELATED [EC:2.4.1.79]
synonym: "globoside synthetase activity" RELATED [EC:2.4.1.79]
synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79]
synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.79]
synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.79]
synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79]
synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79]
synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79]
xref: EC:2.4.1.79
xref: MetaCyc:2.4.1.79-RXN
xref: Reactome:R-HSA-8878914 "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer"
xref: RHEA:22252
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047274
name: galactinol-sucrose galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN]
synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.82]
synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.82]
synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT []
synonym: "galactosyltransferase, galactinol-sucrose" EXACT []
synonym: "raffinose synthase activity" EXACT []
xref: EC:2.4.1.82
xref: MetaCyc:2.4.1.82-RXN
xref: RHEA:20161
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047275
name: obsolete glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [GOC:rynl]
comment: The reason for obsoletion is that this term is equivalent to GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity.
is_obsolete: true
replaced_by: GO:0008499

[Term]
id: GO:0047276
name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity
namespace: molecular_function
alt_id: GO:0003946
def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, RHEA:13013]
synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT []
synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT []
synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" RELATED [EC:2.4.1.87]
xref: EC:2.4.1.87
xref: MetaCyc:2.4.1.151-RXN
xref: RHEA:13013
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047277
name: globoside alpha-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN]
synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88]
synonym: "globoside acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.88]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.88]
synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.88]
xref: EC:2.4.1.88
xref: MetaCyc:2.4.1.88-RXN
xref: RHEA:22164
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047278
name: bilirubin-glucuronoside glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside." [RHEA:16885]
synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT []
synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT []
synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT []
xref: KEGG_REACTION:R00062
xref: RHEA:16885
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047279
name: sn-glycerol-3-phosphate 1-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H+ + UDP." [EC:2.4.1.96, RHEA:20341]
synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" RELATED [EC:2.4.1.96]
synonym: "isofloridoside-phosphate synthase activity" RELATED [EC:2.4.1.96]
synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" RELATED [EC:2.4.1.96]
synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.96]
synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.96]
synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.96]
synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" RELATED [EC:2.4.1.96]
xref: EC:2.4.1.96
xref: KEGG_REACTION:R00854
xref: MetaCyc:2.4.1.96-RXN
xref: RHEA:20341
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047280
name: nicotinamide phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide." [RHEA:16149]
synonym: "nicotinamide mononucleotide pyrophosphorylase activity" RELATED [EC:2.4.2.12]
synonym: "nicotinamide mononucleotide synthetase activity" RELATED [EC:2.4.2.12]
synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.12]
synonym: "NMN diphosphorylase activity" RELATED [EC:2.4.2.12]
synonym: "NMN pyrophosphorylase activity" RELATED [EC:2.4.2.12]
synonym: "NMN synthetase activity" RELATED [EC:2.4.2.12]
xref: EC:2.4.2.12
xref: KEGG_REACTION:R01271
xref: MetaCyc:2.4.2.12-RXN
xref: Reactome:R-HSA-197250 "NAMPT transfers PRIB to NAM to form NAMN"
xref: RHEA:16149
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0047281
name: dioxotetrahydropyrimidine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN]
synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" RELATED [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" RELATED [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" RELATED [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" RELATED [EC:2.4.2.20]
xref: EC:2.4.2.20
xref: MetaCyc:2.4.2.20-RXN
xref: RHEA:10232
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0047282
name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H+." [EC:2.4.2.27, RHEA:24392]
synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" RELATED [EC:2.4.2.27]
synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" RELATED [EC:2.4.2.27]
synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" RELATED [EC:2.4.2.27]
xref: EC:2.4.2.27
xref: KEGG_REACTION:R04222
xref: MetaCyc:2.4.2.27-RXN
xref: RHEA:24392
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0047283
name: dolichyl-phosphate D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN]
synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" RELATED [EC:2.4.2.32]
xref: EC:2.4.2.32
xref: MetaCyc:2.4.2.32-RXN
xref: RHEA:15361
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0047284
name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN]
synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" RELATED [EC:2.4.2.33]
xref: EC:2.4.2.33
xref: MetaCyc:2.4.2.33-RXN
xref: RHEA:18361
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0047285
name: flavonol-3-O-glycoside xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN]
synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.35]
xref: EC:2.4.2.35
xref: MetaCyc:2.4.2.35-RXN
xref: RHEA:19701
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0047286
name: NAD+-diphthamide ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36]
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36]
synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36]
synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" RELATED [EC:2.4.2.36]
synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.36
xref: MetaCyc:RXN-11372
xref: Reactome:R-HSA-5336421 "DT fragment A ADP-ribosylates target cell EEF"
xref: RHEA:11820
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0047287
name: obsolete lactosylceramide alpha-2,6-N-sialyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as GO:0003835 ; beta-galactoside alpha-2,6-sialyltransferase activity.
is_obsolete: true
replaced_by: GO:0003835

[Term]
id: GO:0047288
name: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H+." [EC:2.4.3.2, MetaCyc:2.4.99.2-RXN]
synonym: "monosialoganglioside sialyltransferase" EXACT [EC:2.4.3.2]
xref: EC:2.4.3.2
xref: MetaCyc:2.4.99.2-RXN
xref: RHEA:18021
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047289
name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H+." [EC:2.4.3.5]
xref: EC:2.4.3.5
xref: KEGG_REACTION:R03468
xref: MetaCyc:2.4.99.5-RXN
xref: RHEA:11664
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047290
name: alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP." [RHEA:53896]
synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT []
synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.3.7]
synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.3.7]
synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.3.7]
synonym: "sialyltransferase activity" RELATED [EC:2.4.3.7]
synonym: "ST6GALNAC activity" RELATED [EC:2.4.3.7]
xref: EC:2.4.3.7
xref: KEGG_REACTION:R04635
xref: MetaCyc:2.4.99.7-RXN
xref: Reactome:R-HSA-981809 "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen"
xref: RHEA:53896
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047291
name: lactosylceramide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.3.9, MetaCyc:2.4.99.9-RXN]
synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.3.9]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" RELATED [EC:2.4.3.9]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.3.9]
synonym: "ganglioside GM3 synthase activity" RELATED [EC:2.4.3.9]
synonym: "GM3 synthase activity" RELATED [EC:2.4.3.9]
xref: EC:2.4.3.9
xref: MetaCyc:2.4.99.9-RXN
xref: RHEA:18417
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047292
name: trihydroxypterocarpan dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate." [EC:2.5.1.36]
synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" RELATED [EC:2.5.1.36]
synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" RELATED [EC:2.5.1.36]
synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" RELATED [EC:2.5.1.36]
synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" RELATED [EC:2.5.1.36]
xref: EC:2.5.1.36
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047293
name: obsolete 4-hydroxybenzoate nonaprenyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of 4-hydroxybenzoate polyprenyltransferase activity ; GO:0008412.
is_obsolete: true
replaced_by: GO:0008412

[Term]
id: GO:0047294
name: phosphoglycerol geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate." [PMID:12801917, PMID:17253090, PMID:8408023, RHEA:23404]
comment: This function is involved in archaeal lipid synthesis.
synonym: "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity" EXACT []
synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41]
synonym: "geranylgeranyl-transferase activity" RELATED [EC:2.5.1.41]
synonym: "GGGP synthase activity" EXACT [EC:2.5.1.41]
synonym: "GGGPS activity" EXACT [EC:2.5.1.41]
synonym: "glycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41]
xref: EC:2.5.1.41
xref: KEGG_REACTION:R04158
xref: MetaCyc:2.5.1.41-RXN
xref: RHEA:23404
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0047295
name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate." [PMID:15356000, PMID:16494480, RHEA:18109]
comment: This function is involved in archaeal lipid synthesis.
synonym: "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity" EXACT []
synonym: "DGGGP synthase activity" EXACT [EC:2.5.1.42]
synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42]
synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42]
synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42]
xref: EC:2.5.1.42
xref: KEGG_REACTION:R04520
xref: MetaCyc:2.5.1.42-RXN
xref: RHEA:18109
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0047296
name: homospermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN]
synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" RELATED [EC:2.5.1.44]
xref: EC:2.5.1.44
xref: MetaCyc:2.5.1.44-RXN
xref: RHEA:18645
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047297
name: asparagine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [RHEA:19813]
synonym: "asparagine--oxo-acid aminotransferase activity" RELATED [EC:2.6.1.14]
synonym: "asparagine-keto acid aminotransferase activity" RELATED [EC:2.6.1.14]
synonym: "asparagine-oxo-acid aminotransferase activity" EXACT []
synonym: "L-asparagine:2-oxo-acid aminotransferase activity" RELATED [EC:2.6.1.14]
xref: EC:2.6.1.14
xref: MetaCyc:2.6.1.14-RXN
xref: RHEA:19813
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047298
name: (S)-3-amino-2-methylpropionate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate." [EC:2.6.1.22, RHEA:13993]
synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.22]
synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT []
synonym: "beta-aminobutyric transaminase activity" RELATED [EC:2.6.1.22]
synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.22]
synonym: "L-3-aminoisobutyrate aminotransferase activity" RELATED [EC:2.6.1.22]
synonym: "L-3-aminoisobutyrate transaminase activity" RELATED [EC:2.6.1.22]
synonym: "L-3-aminoisobutyric aminotransferase activity" RELATED [EC:2.6.1.22]
synonym: "L-AIBAT activity" RELATED [EC:2.6.1.22]
xref: EC:2.6.1.22
xref: KEGG_REACTION:R04188
xref: MetaCyc:2.6.1.22-RXN
xref: RHEA:13993
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047299
name: tryptophan-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine." [EC:2.6.1.28, RHEA:13741]
synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" RELATED [EC:2.6.1.28]
synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.28]
synonym: "tryptophan--phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.28]
synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.28
xref: KEGG_REACTION:R01376
xref: MetaCyc:2.6.1.28-RXN
xref: RHEA:13741
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047300
name: pyridoxamine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal." [EC:2.6.1.30, RHEA:12841]
synonym: "pyridoxamine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.30]
synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT []
synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30]
synonym: "pyridoxamine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.30]
synonym: "pyridoxamineu-pyruvic transaminase activity" RELATED [EC:2.6.1.30]
xref: EC:2.6.1.30
xref: KEGG_REACTION:R01712
xref: MetaCyc:2.6.1.30-RXN
xref: RHEA:12841
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047301
name: valine-3-methyl-2-oxovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine." [EC:2.6.1.32, RHEA:11468]
synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" RELATED [EC:2.6.1.32]
synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" RELATED [EC:2.6.1.32]
synonym: "valine--isoleucine aminotransferase activity" RELATED [EC:2.6.1.32]
synonym: "valine--isoleucine transaminase activity" RELATED [EC:2.6.1.32]
synonym: "valine-2-keto-methylvalerate aminotransferase activity" RELATED [EC:2.6.1.32]
synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT []
xref: EC:2.6.1.32
xref: KEGG_REACTION:R02200
xref: MetaCyc:2.6.1.32-RXN
xref: RHEA:11468
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047302
name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose." [PMID:16286454, RHEA:31663]
synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.34]
synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT []
synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT []
synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" RELATED [EC:2.6.1.34]
xref: EC:2.6.1.34
xref: KEGG_REACTION:R04529
xref: MetaCyc:RXN-12812
xref: RHEA:31663
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047303
name: glycine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate." [EC:2.6.1.35, RHEA:17141]
synonym: "glycine--oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.35]
synonym: "glycine-oxalacetate aminotransferase activity" RELATED [EC:2.6.1.35]
synonym: "glycine-oxaloacetate aminotransferase activity" EXACT []
synonym: "glycine:oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.35]
xref: EC:2.6.1.35
xref: KEGG_REACTION:R00373
xref: MetaCyc:2.6.1.35-RXN
xref: RHEA:17141
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047304
name: 2-aminoethylphosphonate-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, RHEA:17021]
synonym: "(2-aminoethyl)phosphonate aminotransferase activity" RELATED [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate transaminase activity" RELATED [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" RELATED [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate aminotransferase activity" RELATED [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.37
xref: KEGG_REACTION:R04152
xref: MetaCyc:2.6.1.37-RXN
xref: RHEA:17021
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047305
name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity
namespace: molecular_function
alt_id: GO:0047314
def: "Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine." [EC:2.6.1.40, RHEA:18393]
comment: Note that this function was EC:2.6.1.61.
synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.40]
synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.40]
synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT []
synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" RELATED [EC:2.6.1.40]
synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" RELATED [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" RELATED [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" RELATED [EC:2.6.1.40]
synonym: "D-AIBAT activity" RELATED [EC:2.6.1.40]
synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.40]
xref: EC:2.6.1.40
xref: KEGG_REACTION:R02050
xref: MetaCyc:2.6.1.40-RXN
xref: Reactome:R-HSA-909780 "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine"
xref: RHEA:18393
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047306
name: D-methionine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine." [EC:2.6.1.41, RHEA:23836]
synonym: "D-methionine aminotransferase activity" RELATED [EC:2.6.1.41]
synonym: "D-methionine transaminase activity" RELATED [EC:2.6.1.41]
synonym: "D-methionine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.41]
synonym: "D-methionine-pyruvate aminotransferase activity" EXACT []
synonym: "D-methionine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.41]
xref: EC:2.6.1.41
xref: KEGG_REACTION:R03001
xref: MetaCyc:2.6.1.41-RXN
xref: RHEA:23836
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047307
name: diaminobutyrate-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde." [EC:2.6.1.46, RHEA:12380]
synonym: "diaminobutyrate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.46]
synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT []
synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.46]
synonym: "L-diaminobutyric acid transaminase activity" RELATED [EC:2.6.1.46]
xref: EC:2.6.1.46
xref: KEGG_REACTION:R02293
xref: MetaCyc:2.6.1.46-RXN
xref: RHEA:12380
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047308
name: alanine-oxomalonate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate." [EC:2.6.1.47, RHEA:18809]
synonym: "alanine--oxomalonate aminotransferase activity" RELATED [EC:2.6.1.47]
synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" RELATED [EC:2.6.1.47]
synonym: "alanine-oxomalonate aminotransferase activity" EXACT []
synonym: "L-alanine-ketomalonate transaminase activity" RELATED [EC:2.6.1.47]
synonym: "L-alanine:oxomalonate aminotransferase activity" RELATED [EC:2.6.1.47]
xref: EC:2.6.1.47
xref: KEGG_REACTION:R02970
xref: MetaCyc:2.6.1.47-RXN
xref: RHEA:18809
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047309
name: dihydroxyphenylalanine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.49, RHEA:15273]
synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.49]
synonym: "aspartate-DOPP transaminase (ADT)" RELATED [EC:2.6.1.49]
synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT []
synonym: "DOPA aminotransferase activity" RELATED [EC:2.6.1.49]
synonym: "dopa transaminase activity" RELATED [EC:2.6.1.49]
synonym: "glutamate-DOPP transaminase (GDT)" RELATED [EC:2.6.1.49]
synonym: "L-dopa transaminase activity" RELATED [EC:2.6.1.49]
synonym: "phenylalanine-DOPP transaminase (PDT)" RELATED [EC:2.6.1.49]
xref: EC:2.6.1.49
xref: KEGG_REACTION:R02077
xref: MetaCyc:2.6.1.49-RXN
xref: RHEA:15273
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047310
name: glutamine-scyllo-inositol transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate." [EC:2.6.1.50, RHEA:22920]
synonym: "glutamine scyllo-inosose aminotransferase activity" RELATED [EC:2.6.1.50]
synonym: "glutamine--scyllo-inosose aminotransferase activity" RELATED [EC:2.6.1.50]
synonym: "glutamine--scyllo-inosose transaminase activity" RELATED [EC:2.6.1.50]
synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT []
synonym: "glutamine-scyllo-inosose transaminase activity" EXACT []
synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" RELATED [EC:2.6.1.50]
synonym: "L-glutamine-scyllo-inosose transaminase activity" RELATED [EC:2.6.1.50]
synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" RELATED [EC:2.6.1.50]
xref: EC:2.6.1.50
xref: KEGG_REACTION:R02781
xref: MetaCyc:2.6.1.50-RXN
xref: RHEA:22920
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0047311
name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine." [EC:2.6.1.56, RHEA:15497]
synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT []
synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" RELATED [EC:2.6.1.56]
synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" RELATED [EC:2.6.1.56]
synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" RELATED [EC:2.6.1.56]
xref: EC:2.6.1.56
xref: KEGG_REACTION:R03502
xref: MetaCyc:2.6.1.56-RXN
xref: RHEA:15497
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047312
name: L-phenylalanine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [RHEA:13053]
synonym: "histidine aminotransferase activity" RELATED [GOC:kad]
synonym: "histidine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.58, GOC:kad]
synonym: "L-histidine:pyruvate aminotransferase activity" RELATED [GOC:kad]
synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58]
synonym: "L-phenylalanine:pyruvate aminotransferase activity" EXACT []
synonym: "L-phenylalanine:pyruvate transaminase activity" EXACT [GOC:kad]
synonym: "phenylalanine (histidine) aminotransferase activity" BROAD [EC:2.6.1.58]
synonym: "phenylalanine(histidine) aminotransferase activity" BROAD []
synonym: "phenylalanine(histidine) transaminase activity" BROAD [EC:2.6.1.58]
synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58]
xref: KEGG_REACTION:R00692
xref: MetaCyc:2.6.1.58-RXN
xref: Reactome:R-HSA-893593 "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine"
xref: RHEA:13053
is_a: GO:0008793 ! aromatic-amino-acid transaminase activity

[Term]
id: GO:0047313
name: aromatic-amino-acid-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN]
synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" RELATED [EC:2.6.1.60]
synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.60]
xref: EC:2.6.1.60
xref: MetaCyc:2.6.1.60-RXN
xref: RHEA:10900
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047315
name: kynurenine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine." [EC:2.6.1.63, RHEA:19249]
synonym: "kynurenine--glyoxylate aminotransferase activity" RELATED [EC:2.6.1.63]
synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT []
synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" RELATED [EC:2.6.1.63]
xref: EC:2.6.1.63
xref: KEGG_REACTION:R01957
xref: MetaCyc:2.6.1.63-RXN
xref: RHEA:19249
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047316
name: glutamine-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine." [EC:2.6.1.64, RHEA:17593]
synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64]
synonym: "glutamine--phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.64]
synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT []
synonym: "L-glutamine:phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.64]
xref: EC:2.6.1.64
xref: KEGG_REACTION:R01375
xref: MetaCyc:2.6.1.64-RXN
xref: RHEA:17593
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0047317
name: N6-acetyl-beta-lysine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN]
synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.65]
synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" RELATED [EC:2.6.1.65]
synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" RELATED [EC:2.6.1.65]
synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT []
xref: EC:2.6.1.65
xref: MetaCyc:2.6.1.65-RXN
xref: RHEA:16889
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047319
name: aspartate-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate." [RHEA:14097]
synonym: "aspartate--phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.70]
synonym: "aspartate:phenylpyruvate aminotransferase activity" EXACT []
synonym: "L-aspartate:phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.70]
xref: EC:2.6.1.70
xref: KEGG_REACTION:R00695
xref: MetaCyc:2.6.1.70-RXN
xref: RHEA:14097
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047320
name: D-4-hydroxyphenylglycine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate." [EC:2.6.1.72, RHEA:15589]
synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT []
synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.72]
synonym: "D-hydroxyphenylglycine aminotransferase activity" RELATED [EC:2.6.1.72]
xref: EC:2.6.1.72
xref: KEGG_REACTION:R04234
xref: MetaCyc:2.6.1.72-RXN
xref: RHEA:15589
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047321
name: diphosphate-protein phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN]
synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1]
synonym: "DiPPT" RELATED [EC:2.7.99.1]
synonym: "pyrophosphate-protein phosphotransferase activity" RELATED [EC:2.7.99.1]
synonym: "pyrophosphate:protein phosphotransferase activity" RELATED [EC:2.7.99.1]
synonym: "triphosphate-protein phosphotransferase activity" RELATED [EC:2.7.99.1]
synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" RELATED [EC:2.7.99.1]
xref: EC:2.7.99.1
xref: MetaCyc:2.7.99.1-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047322
name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" RELATED [EC:2.7.11.31]
synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" RELATED [EC:2.7.11.31]
synonym: "AMPK" RELATED [EC:2.7.11.31]
synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" RELATED [EC:2.7.11.31]
synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" RELATED [EC:2.7.11.31]
synonym: "HMG-CoA reductase kinase activity" RELATED [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" RELATED [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" RELATED [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" RELATED [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" RELATED [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" RELATED [EC:2.7.11.31]
synonym: "reductase kinase activity" BROAD [EC:2.7.11.31]
synonym: "STK29" RELATED [EC:2.7.11.31]
xref: EC:2.7.11.31
xref: MetaCyc:2.7.1.109-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0047323
name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H+ + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]." [RHEA:17301]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" RELATED [EC:2.7.11.4]
synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT []
synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" RELATED [EC:2.7.11.4]
synonym: "BCK" RELATED [EC:2.7.11.4]
synonym: "BCKD kinase activity" RELATED [EC:2.7.11.4]
synonym: "BCODH kinase activity" RELATED [EC:2.7.11.4]
synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" RELATED [EC:2.7.11.4]
synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" RELATED [EC:2.7.11.4]
synonym: "branched-chain keto acid dehydrogenase kinase activity" RELATED [EC:2.7.11.4]
synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.4]
synonym: "STK2" RELATED [EC:2.7.11.4]
xref: EC:2.7.11.4
xref: MetaCyc:2.7.11.4-RXN
xref: Reactome:R-HSA-5693148 "BCKDK phosphorylates BCKDH"
xref: Reactome:R-HSA-9912480 "BCKDK loss-of-function mutations do not phosphorylate BCKDH"
xref: RHEA:17301
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0047324
name: phosphoenolpyruvate-glycerone phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate." [EC:2.7.1.121, RHEA:18381]
synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" RELATED [EC:2.7.1.121]
xref: EC:2.7.1.121
xref: KEGG_REACTION:R01012
xref: MetaCyc:2.7.1.121-RXN
xref: RHEA:18381
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047325
name: inositol-3,4,5,6-tetrakisphosphate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H+." [RHEA:12452]
synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" RELATED [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134]
synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.134]
synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT []
synonym: "inositol tetrakisphosphate 1-kinase activity" BROAD []
synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134]
synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134]
xref: EC:2.7.1.134
xref: KEGG_REACTION:R03479
xref: MetaCyc:2.7.1.134-RXN
xref: Reactome:R-HSA-1855162 "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol"
xref: Reactome:R-HSA-994137 "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5"
xref: RHEA:12452
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0047326
name: inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H+." [RHEA:12717]
synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" BROAD []
synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.140]
synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT []
synonym: "inositol tetrakisphosphate 5-kinase activity" BROAD []
synonym: "inositol-tetrakisphosphate 5-kinase activity" BROAD []
xref: KEGG_REACTION:R03478
xref: MetaCyc:2.7.1.140-RXN
xref: Reactome:R-HSA-1855228 "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus"
xref: RHEA:12717
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0047327
name: glycerol-3-phosphate-glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol." [EC:2.7.1.142, RHEA:21288]
synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.142]
xref: EC:2.7.1.142
xref: KEGG_REACTION:R00850
xref: MetaCyc:2.7.1.142-RXN
xref: RHEA:21288
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047328
name: acyl-phosphate-hexose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN]
synonym: "acyl-phosphate:D-hexose phosphotransferase activity" RELATED [EC:2.7.1.61]
synonym: "hexose phosphate:hexose phosphotransferase activity" RELATED [EC:2.7.1.61]
xref: EC:2.7.1.61
xref: MetaCyc:2.7.1.61-RXN
xref: RHEA:13077
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047329
name: phosphoramidate-hexose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN]
synonym: "phosphoramidate-hexose transphosphorylase activity" RELATED [EC:2.7.1.62]
synonym: "phosphoramidate:hexose 1-phosphotransferase activity" RELATED [EC:2.7.1.62]
synonym: "phosphoramidic-hexose transphosphorylase activity" RELATED [EC:2.7.1.62]
xref: EC:2.7.1.62
xref: MetaCyc:2.7.1.62-RXN
xref: RHEA:10972
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047330
name: polyphosphate-glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN]
synonym: "polyphosphate glucokinase activity" RELATED [EC:2.7.1.63]
synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" RELATED [EC:2.7.1.63]
synonym: "polyphosphate-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.63]
synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.63]
xref: EC:2.7.1.63
xref: MetaCyc:2.7.1.63-RXN
xref: RHEA:22036
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047331
name: diphosphate-glycerol phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H+ + phosphate." [EC:2.7.1.79, RHEA:13689]
synonym: "diphosphate:glycerol 1-phosphotransferase activity" RELATED [EC:2.7.1.79]
synonym: "PPi-glycerol phosphotransferase activity" RELATED [EC:2.7.1.79]
synonym: "pyrophosphate--glycerol phosphotransferase activity" RELATED [EC:2.7.1.79]
xref: EC:2.7.1.79
xref: KEGG_REACTION:R01044
xref: MetaCyc:2.7.1.79-RXN
xref: RHEA:13689
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047332
name: diphosphate-serine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H+ + phosphate." [EC:2.7.1.80, RHEA:23764]
synonym: "diphosphate:L-serine O-phosphotransferase activity" RELATED [EC:2.7.1.80]
synonym: "pyrophosphate--serine phosphotransferase activity" RELATED [EC:2.7.1.80]
synonym: "pyrophosphate-L-serine phosphotransferase activity" RELATED [EC:2.7.1.80]
xref: EC:2.7.1.80
xref: KEGG_REACTION:R00584
xref: MetaCyc:2.7.1.80-RXN
xref: RHEA:23764
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047333
name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H+." [EC:2.7.1.88, RHEA:16281]
synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" RELATED [EC:2.7.1.88]
synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" RELATED [EC:2.7.1.88]
synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" RELATED [EC:2.7.1.88]
synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" RELATED [EC:2.7.1.88]
xref: EC:2.7.1.88
xref: KEGG_REACTION:R03395
xref: MetaCyc:2.7.1.88-RXN
xref: RHEA:16281
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0047334
name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN]
synonym: "6-phosphofructokinase (diphosphate) activity" RELATED [EC:2.7.1.90]
synonym: "6-phosphofructokinase (pyrophosphate) activity" RELATED [EC:2.7.1.90]
synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" RELATED [EC:2.7.1.90]
synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.90]
synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" RELATED [EC:2.7.1.90]
synonym: "inorganic pyrophosphate-phosphofructokinase activity" RELATED [EC:2.7.1.90]
synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.90]
synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" RELATED [EC:2.7.1.90]
synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" RELATED [EC:2.7.1.90]
synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" RELATED [EC:2.7.1.90]
xref: EC:2.7.1.90
xref: MetaCyc:2.7.1.90-RXN
xref: RHEA:13613
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0047335
name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN]
synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.17]
synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.17]
synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.17]
xref: EC:2.7.4.17
xref: MetaCyc:2.7.4.17-RXN
xref: RHEA:18665
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047336
name: 5-methyldeoxycytidine-5'-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H+." [EC:2.7.4.19, RHEA:11396]
synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" RELATED [EC:2.7.4.19]
xref: EC:2.7.4.19
xref: KEGG_REACTION:R04235
xref: MetaCyc:2.7.4.19-RXN
xref: RHEA:11396
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047337
name: dolichyl-diphosphate-polyphosphate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN]
synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.20]
synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.20]
xref: EC:2.7.4.20
xref: MetaCyc:2.7.4.20-RXN
xref: RHEA:19417
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047338
name: UTP:xylose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN]
synonym: "UDP-xylose pyrophosphorylase activity" RELATED [EC:2.7.7.11]
synonym: "uridine diphosphoxylose pyrophosphorylase activity" RELATED [EC:2.7.7.11]
synonym: "uridylyltransferase, xylose 1-phosphate" RELATED [EC:2.7.7.11]
synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11]
synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11]
synonym: "xylose 1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11]
synonym: "xylose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11]
xref: EC:2.7.7.11
xref: MetaCyc:2.7.7.11-RXN
xref: RHEA:18389
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0047339
name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity
namespace: molecular_function
alt_id: GO:0047340
def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN]
synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28]
synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28]
synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW []
synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28]
synonym: "hexose 1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.28]
synonym: "hexose 1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28]
synonym: "hexose nucleotidylating enzyme activity" RELATED [EC:2.7.7.28]
synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW []
synonym: "NDP hexose pyrophosphorylase activity" RELATED [EC:2.7.7.28]
synonym: "NDP-hexose diphosphorylase activity" EXACT []
synonym: "NDP-hexose pyrophosphorylase activity" EXACT []
synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28]
synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28]
synonym: "nucleoside diphosphohexose pyrophosphorylase activity" RELATED [EC:2.7.7.28]
synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28]
xref: EC:2.7.7.28
xref: MetaCyc:2.7.7.28-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047341
name: fucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose." [RHEA:13549]
synonym: "GDP fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30]
synonym: "GDP-fucose diphosphorylase activity" RELATED [EC:2.7.7.30]
synonym: "GDP-fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30]
synonym: "GDP-L-fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30]
synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.30]
synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.30]
synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30]
xref: EC:2.7.7.30
xref: KEGG_REACTION:R01951
xref: MetaCyc:2.7.7.30-RXN
xref: Reactome:R-HSA-6787533 "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc"
xref: RHEA:13549
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047342
name: galactose-1-phosphate thymidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose." [EC:2.7.7.32, RHEA:17165]
synonym: "dTDP galactose pyrophosphorylase activity" RELATED [EC:2.7.7.32]
synonym: "dTDP-galactose diphosphorylase activity" RELATED [EC:2.7.7.32]
synonym: "dTDP-galactose pyrophosphorylase activity" RELATED [EC:2.7.7.32]
synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.32]
synonym: "galactose 1-phosphate thymidylyl transferase activity" RELATED [EC:2.7.7.32]
synonym: "thymidine diphosphogalactose pyrophosphorylase activity" RELATED [EC:2.7.7.32]
synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.32]
xref: EC:2.7.7.32
xref: KEGG_REACTION:R02329
xref: MetaCyc:2.7.7.32-RXN
xref: RHEA:17165
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047343
name: glucose-1-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, RHEA:18213]
synonym: "CDP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33]
synonym: "CDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.33]
synonym: "CDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33]
synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.33]
synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.33]
synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT []
synonym: "cytidine diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33]
synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33]
synonym: "cytidine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.33]
xref: EC:2.7.7.33
xref: KEGG_REACTION:R00956
xref: MetaCyc:2.7.7.33-RXN
xref: RHEA:18213
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047344
name: glucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose." [RHEA:10708]
synonym: "GDP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.34]
synonym: "GDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.34]
synonym: "GDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.34]
synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.34]
synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.34]
xref: EC:2.7.7.34
xref: KEGG_REACTION:R00954
xref: MetaCyc:2.7.7.34-RXN
xref: RHEA:10708
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047345
name: ribose-5-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ADP + H+ = ADP-ribose + phosphate." [EC:2.7.7.35, RHEA:14529]
synonym: "adenosine diphosphoribose phosphorylase activity" RELATED [EC:2.7.7.35]
synonym: "ADP ribose phosphorylase activity" RELATED [EC:2.7.7.35]
synonym: "ADP-ribose phosphorylase activity" RELATED [EC:2.7.7.35]
synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.35]
synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT []
xref: EC:2.7.7.35
xref: KEGG_REACTION:R01052
xref: MetaCyc:2.7.7.35-RXN
xref: RHEA:14529
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047346
name: aldose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN]
synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" RELATED [EC:2.7.7.36]
synonym: "adenosine diphosphosugar phosphorylase activity" RELATED [EC:2.7.7.36]
synonym: "ADP sugar phosphorylase activity" RELATED [EC:2.7.7.36]
synonym: "ADP-aldose phosphorylase activity" RELATED [EC:2.7.7.36]
synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36]
synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT []
synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.36]
synonym: "ADPaldose phosphorylase activity" RELATED [EC:2.7.7.36]
synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36]
xref: EC:2.7.7.36
xref: MetaCyc:2.7.7.36-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047347
name: aldose-1-phosphate nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN]
synonym: "glucose 1-phosphate inosityltransferase activity" RELATED [EC:2.7.7.37]
synonym: "NDP sugar phosphorylase activity" RELATED [EC:2.7.7.37]
synonym: "NDP-aldose phosphorylase activity" RELATED [EC:2.7.7.37]
synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37]
synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37]
synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37]
synonym: "NDPaldose phosphorylase activity" RELATED [EC:2.7.7.37]
synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37]
synonym: "nucleoside diphosphosugar phosphorylase activity" RELATED [EC:2.7.7.37]
synonym: "sugar nucleotide phosphorylase activity" RELATED [EC:2.7.7.37]
synonym: "sugar phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37]
synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37]
xref: EC:2.7.7.37
xref: MetaCyc:2.7.7.37-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047348
name: glycerol-3-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate." [EC:2.7.7.39, RHEA:13361]
synonym: "CDP-glycerol diphosphorylase activity" RELATED [EC:2.7.7.39]
synonym: "CDP-glycerol pyrophosphorylase activity" RELATED [EC:2.7.7.39]
synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.39]
synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.39]
synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" RELATED [EC:2.7.7.39]
synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" RELATED [EC:2.7.7.39]
synonym: "Gro-PCT" RELATED [EC:2.7.7.39]
xref: EC:2.7.7.39
xref: KEGG_REACTION:R00856
xref: MetaCyc:2.7.7.39-RXN
xref: RHEA:13361
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047349
name: D-ribitol-5-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, RHEA:12456]
synonym: "CDP ribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40]
synonym: "CDP-ribitol diphosphorylase activity" RELATED [EC:2.7.7.40]
synonym: "CDP-ribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40]
synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT []
synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40]
synonym: "cytidine diphosphoribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40]
synonym: "ribitol 5-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.40]
xref: EC:2.7.7.40
xref: KEGG_REACTION:R02921
xref: MetaCyc:2.7.7.40-RXN
xref: RHEA:12456
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047350
name: glucuronate-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate." [EC:2.7.7.44, RHEA:16325]
synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" RELATED [EC:2.7.7.44]
synonym: "UDP-glucuronate pyrophosphorylase activity" RELATED [EC:2.7.7.44]
synonym: "UDP-glucuronic acid pyrophosphorylase activity" RELATED [EC:2.7.7.44]
synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" RELATED [EC:2.7.7.44]
synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" RELATED [EC:2.7.7.44]
synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT []
xref: EC:2.7.7.44
xref: KEGG_REACTION:R01381
xref: MetaCyc:2.7.7.44-RXN
xref: RHEA:16325
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0047351
name: GTP guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 GTP + H+ = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H+." [RHEA:18153]
synonym: "GTP:GTP guanylyltransferase activity" BROAD []
synonym: "guanosine-triphosphate guanylyltransferase activity" EXACT []
xref: EC:2.7.7.45
xref: KEGG_REACTION:R00012
xref: MetaCyc:2.7.7.45-RXN
xref: RHEA:18153
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047352
name: adenylylsulfate-ammonia adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-adenylyl sulfate + NH4 = adenosine 5'-phosphoramidate + 2 H+ + sulfate." [EC:2.7.7.51, RHEA:19197]
synonym: "adenylylsulfate:ammonia adenylyltransferase activity" RELATED [EC:2.7.7.51]
synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT []
synonym: "APSAT" RELATED [EC:2.7.7.51]
xref: EC:2.7.7.51
xref: KEGG_REACTION:R01619
xref: MetaCyc:2.7.7.51-RXN
xref: RHEA:19197
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047353
name: N-methylphosphoethanolamine cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate." [EC:2.7.7.57, RHEA:10576]
synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.57]
synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT []
synonym: "CTP:P-MEA cytidylyltransferase activity" RELATED [EC:2.7.7.57]
synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.57]
xref: EC:2.7.7.57
xref: KEGG_REACTION:R03375
xref: MetaCyc:2.7.7.57-RXN
xref: RHEA:10576
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047354
name: sphingosine cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + sphingosine = CMP + H+ + sphingosyl-phosphocholine." [EC:2.7.8.10, RHEA:21224]
synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.10]
synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.10]
synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.10]
synonym: "phosphorylcholine-sphingosine transferase activity" RELATED [EC:2.7.8.10]
synonym: "sphingosine choline phosphotransferase activity" EXACT []
xref: EC:2.7.8.10
xref: KEGG_REACTION:R01929
xref: MetaCyc:2.7.8.10-RXN
xref: RHEA:21224
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047355
name: CDP-glycerol glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12]
synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" RELATED [EC:2.7.8.12]
synonym: "CDPglycerol glycerophosphotransferase activity" RELATED [EC:2.7.8.12]
synonym: "CGPTase activity" RELATED [EC:2.7.8.12]
synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" RELATED [EC:2.7.8.12]
synonym: "glycerophosphate synthetase activity" RELATED [EC:2.7.8.12]
synonym: "poly(glycerol phosphate) polymerase activity" RELATED [EC:2.7.8.12]
synonym: "teichoic acid glycerol transferase activity" RELATED [EC:2.7.8.12]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12]
xref: EC:2.7.8.12
xref: MetaCyc:TEICHOICSYN4-RXN
xref: RHEA:13565
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047356
name: CDP-ribitol ribitolphosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14]
synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" RELATED [EC:2.7.8.14]
synonym: "CDPribitol ribitolphosphotransferase activity" RELATED [EC:2.7.8.14]
synonym: "poly(ribitol phosphate) synthetase activity" RELATED [EC:2.7.8.14]
synonym: "polyribitol phosphate polymerase activity" RELATED [EC:2.7.8.14]
synonym: "polyribitol phosphate synthetase activity" RELATED [EC:2.7.8.14]
synonym: "teichoate synthase activity" RELATED [EC:2.7.8.14]
synonym: "teichoate synthetase activity" RELATED [EC:2.7.8.14]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14]
xref: EC:2.7.8.14
xref: MetaCyc:RXN-18380
xref: RHEA:13353
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047357
name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, RHEA:22440]
synonym: "galactose-1-phosphotransferase activity" RELATED [EC:2.7.8.18]
synonym: "galactosyl phosphotransferase activity" RELATED [EC:2.7.8.18]
synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" RELATED [EC:2.7.8.18]
synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" RELATED [EC:2.7.8.18]
synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" RELATED [EC:2.7.8.18]
synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" RELATED [EC:2.7.8.18]
xref: EC:2.7.8.18
xref: KEGG_REACTION:R00504
xref: MetaCyc:2.7.8.18-RXN
xref: RHEA:22440
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047358
name: UDP-glucose-glycoprotein glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN]
synonym: "Glc-phosphotransferase activity" RELATED [EC:2.7.8.19]
synonym: "GlcPTase activity" RELATED [EC:2.7.8.19]
synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" RELATED [EC:2.7.8.19]
synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" RELATED [EC:2.7.8.19]
synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" RELATED [EC:2.7.8.19]
synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" RELATED [EC:2.7.8.19]
synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" RELATED [EC:2.7.8.19]
xref: EC:2.7.8.19
xref: MetaCyc:2.7.8.19-RXN
xref: RHEA:20181
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047359
name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN]
synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" RELATED [EC:2.7.8.22]
synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.22]
xref: EC:2.7.8.22
xref: MetaCyc:2.7.8.22-RXN
xref: RHEA:36227
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047360
name: undecaprenyl-phosphate galactose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, RHEA:11652]
synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" RELATED [EC:2.7.8.6]
synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" RELATED [EC:2.7.8.6]
synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" RELATED [EC:2.7.8.6]
synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" RELATED [EC:2.7.8.6]
synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" RELATED [EC:2.7.8.6]
xref: EC:2.7.8.6
xref: KEGG_REACTION:R01535
xref: MetaCyc:2.7.8.6-RXN
xref: RHEA:11652
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047361
name: phosphomannan mannosephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN]
synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" RELATED [EC:2.7.8.9]
xref: EC:2.7.8.9
xref: MetaCyc:2.7.8.9-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047362
name: thiosulfate-dithiol sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN]
synonym: "thiosulfate reductase activity" RELATED [EC:2.8.1.5]
synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" RELATED [EC:2.8.1.5]
synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT []
synonym: "TSR" RELATED [EC:2.8.1.5]
xref: EC:2.8.1.5
xref: MetaCyc:2.8.1.5-RXN
xref: RHEA:15121
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0047363
name: triglucosylalkylacylglycerol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN]
synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" RELATED [EC:2.8.2.19]
synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT []
synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" RELATED [EC:2.8.2.19]
xref: EC:2.8.2.19
xref: MetaCyc:2.8.2.19-RXN
xref: RHEA:13273
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047364
name: aromatic desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate = (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H+. Also converts (Z)-indolylmethyl desulfoglucosinolate to (Z)-glucobrassicin. This is the final step in the biosynthesis of the glucosinolate core structure." [EC:2.8.2.24]
synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" RELATED [EC:2.8.2.24]
synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" RELATED [EC:2.8.2.24]
synonym: "desulfoglucosinolate sulfotransferase activity" BROAD []
synonym: "desulphoglucosinolate sulphotransferase activity" EXACT []
synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" RELATED [EC:2.8.2.24]
xref: EC:2.8.2.24
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047365
name: quercetin-3-sulfate 3'-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,3'-disulfate." [EC:2.8.2.26, RHEA:22504]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" RELATED [EC:2.8.2.26]
synonym: "3'-sulfotransferase activity" RELATED [EC:2.8.2.26]
synonym: "flavonol 3'-sulfotransferase activity" RELATED [EC:2.8.2.26]
synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" RELATED [EC:2.8.2.26]
synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT []
xref: EC:2.8.2.26
xref: KEGG_REACTION:R02632
xref: MetaCyc:2.8.2.26-RXN
xref: RHEA:22504
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047366
name: quercetin-3-sulfate 4'-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,4'-disulfate." [EC:2.8.2.27, RHEA:17205]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" RELATED [EC:2.8.2.27]
synonym: "flavonol 4'-sulfotransferase activity" RELATED [EC:2.8.2.27]
synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" RELATED [EC:2.8.2.27]
synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT []
xref: EC:2.8.2.27
xref: KEGG_REACTION:R02633
xref: MetaCyc:2.8.2.27-RXN
xref: RHEA:17205
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047367
name: quercetin-3,3'-bissulfate 7-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" RELATED [EC:2.8.2.28]
synonym: "7-sulfotransferase activity" RELATED [EC:2.8.2.28]
synonym: "flavonol 7-sulfotransferase activity" RELATED [EC:2.8.2.28]
synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" RELATED [EC:2.8.2.28]
synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT []
xref: EC:2.8.2.28
xref: MetaCyc:2.8.2.28-RXN
xref: RHEA:21860
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047368
name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H+ + UDP-N-acetyl-D-galactosamine 4,6-disulfate." [EC:2.8.2.7, RHEA:14337]
synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" RELATED [EC:2.8.2.7]
synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT []
synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" RELATED [EC:2.8.2.7]
synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" RELATED [EC:2.8.2.7]
xref: EC:2.8.2.7
xref: KEGG_REACTION:R04476
xref: MetaCyc:2.8.2.7-RXN
xref: RHEA:14337
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047369
name: succinate-hydroxymethylglutarate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN]
synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" RELATED [EC:2.8.3.13]
synonym: "hydroxymethylglutarate coenzyme A-transferase activity" RELATED [EC:2.8.3.13]
synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" RELATED [EC:2.8.3.13]
xref: EC:2.8.3.13
xref: MetaCyc:2.8.3.13-RXN
xref: RHEA:12284
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047370
name: succinate-citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [PMID:16547052, RHEA:38287]
synonym: "citramalate coenzyme A-transferase activity" EXACT []
synonym: "itaconate CoA-transferase activity" EXACT []
synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT []
synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT []
xref: MetaCyc:2.8.3.7-RXN
xref: RHEA:38287
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047371
name: butyrate-acetoacetate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate." [EC:2.8.3.9, RHEA:12961]
synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" RELATED [EC:2.8.3.9]
synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" RELATED [EC:2.8.3.9]
synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" RELATED [EC:2.8.3.9]
xref: EC:2.8.3.9
xref: KEGG_REACTION:R01365
xref: MetaCyc:2.8.3.9-RXN
xref: RHEA:12961
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047372
name: monoacylglycerol lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+." [RHEA:15245]
subset: goslim_chembl
synonym: "acylglycerol lipase activity" BROAD []
synonym: "fatty acyl monoester lipase activity" RELATED [EC:3.1.1.23]
synonym: "glycerol-ester acylhydrolase activity" RELATED [EC:3.1.1.23]
synonym: "monoacylglycerol hydrolase activity" RELATED [EC:3.1.1.23]
synonym: "monoacylglycerolipase activity" RELATED [EC:3.1.1.23]
synonym: "monoglyceridase activity" RELATED [EC:3.1.1.23]
synonym: "monoglyceride hydrolase activity" RELATED [EC:3.1.1.23]
synonym: "monoglyceride lipase activity" RELATED [EC:3.1.1.23]
synonym: "monoglyceridyllipase activity" RELATED [EC:3.1.1.23]
xref: EC:3.1.1.23
xref: MetaCyc:RXN-19280
xref: Reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL"
xref: Reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid"
xref: Reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase"
xref: Reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)"
xref: Reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)"
xref: Reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase"
xref: Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2"
xref: Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG"
xref: Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL"
xref: Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG"
xref: RHEA:15245
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0047373
name: acetoxybutynylbithiophene deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H+." [EC:3.1.1.54, RHEA:11548]
synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" RELATED [EC:3.1.1.54]
synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" RELATED [EC:3.1.1.54]
synonym: "acetoxybutynylbithiophene esterase activity" RELATED [EC:3.1.1.54]
xref: EC:3.1.1.54
xref: KEGG_REACTION:R04490
xref: MetaCyc:3.1.1.54-RXN
xref: RHEA:11548
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047374
name: methylumbelliferyl-acetate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+." [EC:3.1.1.56, RHEA:12208]
synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" RELATED [EC:3.1.1.56]
synonym: "esterase D activity" RELATED [EC:3.1.1.56]
xref: EC:3.1.1.56
xref: KEGG_REACTION:R04141
xref: MetaCyc:3.1.1.56-RXN
xref: RHEA:12208
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047375
name: N-acetylgalactosaminoglycan deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN]
synonym: "N-acetyl galactosaminoglycan deacetylase activity" RELATED [EC:3.1.1.58]
synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" RELATED [EC:3.1.1.58]
synonym: "polysaccharide deacetylase activity" RELATED [EC:3.1.1.58]
synonym: "Vi-polysaccharide deacetylase activity" RELATED [EC:3.1.1.58]
xref: EC:3.1.1.58
xref: MetaCyc:3.1.1.58-RXN
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047376
name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [RHEA:13933]
synonym: "all-trans-retinyl-palmitate acylhydrolase activity" BROAD []
synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD []
synonym: "retinyl-palmitate palmitohydrolase activity" BROAD [KEGG_REACTION:R02368]
xref: KEGG_REACTION:R02368
xref: MetaCyc:3.1.1.64-RXN
xref: Reactome:R-HSA-2404140 "NREH hydrolyses atREs to atROL and FAs"
xref: Reactome:R-HSA-2429643 "NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs"
xref: RHEA:13933
is_a: GO:0050253 ! retinyl-palmitate esterase activity

[Term]
id: GO:0047377
name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H+." [EC:3.1.1.66, RHEA:16313]
synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" RELATED [EC:3.1.1.66]
synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" RELATED [EC:3.1.1.66]
synonym: "diacetoxybutynylbithiophene acetate esterase activity" RELATED [EC:3.1.1.66]
xref: EC:3.1.1.66
xref: KEGG_REACTION:R04525
xref: MetaCyc:3.1.1.66-RXN
xref: RHEA:16313
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047378
name: acetylalkylglycerol acetylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate + H+." [EC:3.1.1.71, RHEA:11552]
synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" RELATED [EC:3.1.1.71]
synonym: "alkylacetylglycerol acetylhydrolase activity" RELATED [EC:3.1.1.71]
xref: EC:3.1.1.71
xref: KEGG_REACTION:R04043
xref: MetaCyc:3.1.1.71-RXN
xref: RHEA:11552
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047379
name: obsolete ADP-dependent short-chain-acyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN]
comment: This term was obsoleted because there is no evidence that this activity exists; the mechanism of ADP-dependency has not been demonstrated.
synonym: "ADP-dependent propionyl coenzyme A hydrolase activity" NARROW [EC:3.1.2.18]
synonym: "ADP-dependent propionyl-CoA hydrolase activity" NARROW [EC:3.1.2.18]
synonym: "ADP-dependent propionyl-CoA thioesterase activity" NARROW [EC:3.1.2.18]
synonym: "ADP-dependent short-chain acyl-CoA hydrolase activity" RELATED [EC:3.1.2.18]
synonym: "ADP-dependent short-chain acyl-CoA thioesterase activity" RELATED [EC:3.1.2.18]
synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.18]
is_obsolete: true
replaced_by: GO:0016937

[Term]
id: GO:0047380
name: obsolete ADP-dependent medium-chain-acyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN]
comment: This term was obsoleted because there is no evidence that this activity exists; the mechanism of ADP-dependency has not been demonstrated.
synonym: "ADP-dependent medium-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19]
synonym: "ADP-dependent medium-chain acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19]
synonym: "ADP-dependent medium-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19]
synonym: "ADP-dependent medium-chain hydrolase activity" RELATED [EC:3.1.2.19]
synonym: "ADP-dependent myristoyl-CoA thioesterase activity" NARROW [EC:3.1.2.19]
synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19]
is_obsolete: true
replaced_by: GO:0052815

[Term]
id: GO:0047381
name: obsolete dodecanoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dodecanoyl-[ACP] + H2O = dodecanoate + H+ + holo-[ACP]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of fatty acyl-[ACP] hydrolase activity ; GO:0016297.
synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "dodecanoyl-ACP hydrolase activity" EXACT []
synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT []
synonym: "lauroyl-ACP hydrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016297

[Term]
id: GO:0047382
name: methylphosphothioglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate." [EC:3.1.3.14, RHEA:16081]
synonym: "methylthiophosphoglycerate phosphatase activity" RELATED [EC:3.1.3.14]
synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" RELATED [EC:3.1.3.14]
xref: EC:3.1.3.14
xref: KEGG_REACTION:R04317
xref: MetaCyc:3.1.3.14-RXN
xref: RHEA:16081
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047383
name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate." [EC:3.1.3.40, RHEA:15777]
synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" RELATED [EC:3.1.3.40]
synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" RELATED [EC:3.1.3.40]
synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" RELATED [EC:3.1.3.40]
xref: EC:3.1.3.40
xref: KEGG_REACTION:R03496
xref: MetaCyc:3.1.3.40-RXN
xref: RHEA:15777
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047384
name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" RELATED [EC:3.1.3.47]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.47]
synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47]
xref: EC:3.1.3.47
xref: MetaCyc:3.1.3.47-RXN
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0047385
name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate." [EC:3.1.3.52]
synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" EXACT []
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" EXACT []
synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" EXACT []
xref: EC:3.1.3.52
xref: MetaCyc:3.1.3.52-RXN
xref: RHEA:77247
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0047386
name: fructose-2,6-bisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate." [EC:3.1.3.54, RHEA:13333]
synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.54]
synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.54]
synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" RELATED [EC:3.1.3.54]
synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.54]
xref: EC:3.1.3.54
xref: KEGG_REACTION:R02730
xref: MetaCyc:3.1.3.54-RXN
xref: RHEA:13333
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0047387
name: serine-ethanolaminephosphate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + serine phosphoethanolamine = H+ + phosphoethanolamine + serine." [EC:3.1.4.13, RHEA:17113]
synonym: "SEP diesterase activity" RELATED [EC:3.1.4.13]
synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" RELATED [EC:3.1.4.13]
synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" RELATED [EC:3.1.4.13]
xref: EC:3.1.4.13
xref: KEGG_REACTION:R02817
xref: MetaCyc:3.1.4.13-RXN
xref: RHEA:17113
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047388
name: [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP." [RHEA:43716]
synonym: "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase" RELATED []
synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT []
synonym: "adenylyl-[glutamate-ammonia ligase] hydrolase activity" EXACT []
synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT []
synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT []
synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT []
xref: EC:2.7.7.89
xref: KEGG_REACTION:R03474
xref: MetaCyc:GSDEADENYLATION-RXN
xref: RHEA:43716
is_a: GO:0016779 ! nucleotidyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0047389
name: glycerophosphocholine phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]
synonym: "glycerolphosphorylcholine phosphodiesterase activity" RELATED [EC:3.1.4.2]
synonym: "glycerophosphinicocholine diesterase activity" RELATED [EC:3.1.4.2]
synonym: "glycerophosphohydrolase activity" RELATED [EC:3.1.4.2]
synonym: "glycerylphosphorylcholinediesterase activity" RELATED [EC:3.1.4.2]
synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" RELATED [EC:3.1.4.2]
synonym: "sn-glycero-3-phosphorylcholine diesterase activity" RELATED [EC:3.1.4.2]
xref: EC:3.1.4.2
xref: MetaCyc:3.1.4.2-RXN
xref: Reactome:R-HSA-6814132 "GDPD5 hydrolyzes GPCho"
xref: RHEA:16061
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047390
name: glycerophosphocholine cholinephosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycero-3-phosphocholine + H2O = choline phosphate + glycerol + H+." [EC:3.1.4.38, RHEA:19545]
synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" RELATED [EC:3.1.4.38]
synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" RELATED [EC:3.1.4.38]
xref: EC:3.1.4.38
xref: KEGG_REACTION:R02591
xref: MetaCyc:3.1.4.38-RXN
xref: Reactome:R-HSA-6814797 "ENPP6 hydrolyzes lysophosphatidylcholine"
xref: RHEA:19545
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047391
name: alkylglycerophosphoethanolamine phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN]
synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" RELATED [EC:3.1.4.39]
synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39]
xref: EC:3.1.4.39
xref: MetaCyc:3.1.4.39-RXN
xref: RHEA:15965
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047392
name: CMP-N-acylneuraminate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN]
synonym: "CMP-N-acetylneuraminate hydrolase activity" RELATED [EC:3.1.4.40]
synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" RELATED [EC:3.1.4.40]
synonym: "CMP-N-acylneuraminic acid hydrolase activity" RELATED [EC:3.1.4.40]
synonym: "CMP-sialate hydrolase activity" RELATED [EC:3.1.4.40]
synonym: "CMP-sialic acid hydrolase activity" RELATED [EC:3.1.4.40]
synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" RELATED [EC:3.1.4.40]
synonym: "cytidine monophosphosialate hydrolase activity" RELATED [EC:3.1.4.40]
synonym: "cytidine monophosphosialic hydrolase activity" RELATED [EC:3.1.4.40]
xref: EC:3.1.4.40
xref: MetaCyc:3.1.4.40-RXN
xref: RHEA:20185
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047393
name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H+." [EC:3.1.4.42, RHEA:16493]
synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" RELATED [EC:3.1.4.42]
synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" RELATED [EC:3.1.4.42]
xref: EC:3.1.4.42
xref: KEGG_REACTION:R02648
xref: MetaCyc:3.1.4.42-RXN
xref: RHEA:16493
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047394
name: glycerophosphoinositol inositolphosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN]
synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT []
synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" RELATED [EC:3.1.4.43]
synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" RELATED [EC:3.1.4.43]
synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" RELATED [EC:3.1.4.43]
synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" RELATED [EC:3.1.4.43]
synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" RELATED [EC:3.1.4.43]
synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" RELATED [EC:3.1.4.43]
xref: EC:3.1.4.43
xref: MetaCyc:3.1.4.43-RXN
xref: RHEA:14033
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047395
name: glycerophosphoinositol glycerophosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+." [EC:3.1.4.44, RHEA:16501]
synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" RELATED [EC:3.1.4.44]
synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" RELATED [EC:3.1.4.44]
synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" RELATED [EC:3.1.4.44]
xref: EC:3.1.4.44
xref: KEGG_REACTION:R01193
xref: MetaCyc:3.1.4.44-RXN
xref: Reactome:R-HSA-6813740 "GDE1 hydrolyzes GroPIns"
xref: RHEA:16501
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047396
name: glycosylphosphatidylinositol diacylglycerol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN]
synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" RELATED [EC:4.6.1.14]
synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14]
synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" RELATED [EC:4.6.1.14]
synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" RELATED [EC:4.6.1.14]
synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14]
synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" RELATED [EC:4.6.1.14]
synonym: "GPI-PLC activity" RELATED [EC:4.6.1.14]
synonym: "GPI-specific phospholipase C activity" RELATED [EC:4.6.1.14]
synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT []
synonym: "VSG-lipase activity" RELATED [EC:4.6.1.14]
xref: EC:4.6.1.14
xref: MetaCyc:3.1.4.47-RXN
xref: RHEA:14333
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0047397
name: dolichylphosphate-glucose phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN]
synonym: "Dol-P-Glc phosphodiesterase activity" RELATED [EC:3.1.4.48]
synonym: "dolichol phosphoglucose phosphodiesterase activity" RELATED [EC:3.1.4.48]
synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" RELATED [EC:3.1.4.48]
synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT []
xref: EC:3.1.4.48
xref: MetaCyc:3.1.4.48-RXN
xref: RHEA:13857
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047398
name: dolichylphosphate-mannose phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN]
synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" RELATED [EC:3.1.4.49]
synonym: "mannosylphosphodolichol phosphodiesterase activity" RELATED [EC:3.1.4.49]
xref: EC:3.1.4.49
xref: MetaCyc:3.1.4.49-RXN
xref: RHEA:12989
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047399
name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN]
synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" RELATED [EC:3.1.4.51]
synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" RELATED [EC:3.1.4.51]
xref: EC:3.1.4.51
xref: MetaCyc:3.1.4.51-RXN
xref: RHEA:18045
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0047400
name: phosphonoacetate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phosphonoacetate = acetate + H+ + phosphate." [RHEA:16749]
synonym: "phosphonoacetate phosphonohydrolase activity" RELATED [EC:3.11.1.2]
xref: EC:3.11.1.2
xref: KEGG_REACTION:R00318
xref: MetaCyc:3.11.1.2-RXN
xref: RHEA:16749
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0047401
name: trithionate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + trithionate = H+ + sulfate + thiosulfate." [RHEA:21884]
synonym: "trithionate thiosulfohydrolase activity" RELATED [EC:3.12.1.1]
xref: EC:3.12.1.1
xref: KEGG_REACTION:R01930
xref: MetaCyc:3.12.1.1-RXN
xref: RHEA:21884
is_a: GO:0016828 ! hydrolase activity, acting on acid sulfur-sulfur bonds

[Term]
id: GO:0047402
name: protein-glucosylgalactosylhydroxylysine glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN]
synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" RELATED [EC:3.2.1.107]
synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" RELATED [EC:3.2.1.107]
xref: EC:3.2.1.107
xref: MetaCyc:3.2.1.107-RXN
xref: RHEA:11068
is_a: GO:0015926 ! glucosidase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0047403
name: lacto-N-biosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140]
synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140]
xref: EC:3.2.1.140
xref: MetaCyc:RXN-8731
xref: RHEA:21568
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047404
name: glucuronosyl-disulfoglucosamine glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine." [EC:3.2.1.56]
synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" RELATED [EC:3.2.1.56]
synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" RELATED [EC:3.2.1.56]
synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT []
xref: EC:3.2.1.56
xref: MetaCyc:RXN-16484
xref: RHEA:15073
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047405
name: pyrimidine-5'-nucleotide nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN]
synonym: "Pyr5N activity" RELATED [EC:3.2.2.10]
synonym: "pyrimidine nucleotide N-ribosidase activity" RELATED [EC:3.2.2.10]
synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" RELATED [EC:3.2.2.10]
xref: EC:3.2.2.10
xref: MetaCyc:3.2.2.10-RXN
xref: RHEA:13425
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047406
name: beta-aspartyl-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-D-glucosamine + L-asparagine." [EC:3.2.2.11, RHEA:12324]
synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" RELATED [EC:3.2.2.11]
synonym: "beta-aspartylacetylglucosaminidase activity" RELATED [EC:3.2.2.11]
xref: EC:3.2.2.11
xref: KEGG_REACTION:R01266
xref: MetaCyc:3.2.2.11-RXN
xref: RHEA:12324
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047407
name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN]
synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.24]
synonym: "ADP-ribosyl glycohydrolase activity" RELATED [EC:3.2.2.24]
synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" RELATED [EC:3.2.2.24]
synonym: "azoferredoxin glycosidase activity" RELATED [EC:3.2.2.24]
synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24]
synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24]
synonym: "dinitrogenase reductase-activating glycohydrolase activity" RELATED [EC:3.2.2.24]
xref: EC:3.2.2.24
xref: MetaCyc:3.2.2.24-RXN
xref: RHEA:14493
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047408
name: alkenylglycerophosphocholine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN]
synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" RELATED [EC:3.3.2.2]
synonym: "lysoplasmalogenase activity" RELATED [EC:3.3.2.2]
xref: EC:3.3.2.2
xref: MetaCyc:3.3.2.2-RXN
xref: RHEA:22544
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0047409
name: obsolete alkenylglycerophosphoethanolamine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN]
comment: This term was obsoleted because the EC number to which it was associated was transferred to EC:3.3.2.2; which corresponds to alkenylglycerophosphocholine hydrolase activity ; GO:0047408.
synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" RELATED [EC:3.3.2.5]
is_obsolete: true
replaced_by: GO:0047408

[Term]
id: GO:0047410
name: obsolete N-formylmethionylaminoacyl-tRNA deformylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [MetaCyc:3.5.1.27-RXN]
comment: This term was obsoleted because there is no evidence that this activity exists.
synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0047411
name: 2-(acetamidomethylene)succinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN]
synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" RELATED [EC:3.5.1.29]
synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" RELATED [EC:3.5.1.29]
xref: EC:3.5.1.29
xref: MetaCyc:3.5.1.29-RXN
xref: RHEA:10432
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047412
name: N-(long-chain-acyl)ethanolamine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN]
synonym: "acylethanolamine amidase activity" EXACT []
synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT []
synonym: "N-acylethanolamine amidohydrolase activity" EXACT []
xref: EC:3.5.1.60
xref: MetaCyc:3.5.1.60-RXN
xref: RHEA:17505
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047413
name: N(alpha)-benzyloxycarbonylleucine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H2O + H+ = L-leucine + benzyl alcohol + CO2." [EC:3.5.1.64, RHEA:18901]
synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" RELATED [EC:3.5.1.64]
synonym: "benzyloxycarbonylleucine hydrolase activity" RELATED [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" RELATED [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" RELATED [EC:3.5.1.64]
xref: EC:3.5.1.64
xref: KEGG_REACTION:R02552
xref: MetaCyc:3.5.1.64-RXN
xref: RHEA:18901
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047414
name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H+ = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4." [EC:3.5.1.66, RHEA:17677]
synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" RELATED [EC:3.5.1.66]
synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" RELATED [EC:3.5.1.66]
synonym: "compound B hydrolase activity" RELATED [EC:3.5.1.66]
xref: EC:3.5.1.66
xref: KEGG_REACTION:R04397
xref: MetaCyc:3.5.1.66-RXN
xref: RHEA:17677
xref: Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating\,_decarboxylating)
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047415
name: D-benzoylarginine-4-nitroanilide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H+." [EC:3.5.1.72, RHEA:14421]
synonym: "benzoyl-D-arginine arylamidase activity" RELATED [EC:3.5.1.72]
synonym: "D-BAPA-ase activity" RELATED [EC:3.5.1.72]
synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" RELATED [EC:3.5.1.72]
xref: EC:3.5.1.72
xref: KEGG_REACTION:R04113
xref: MetaCyc:3.5.1.72-RXN
xref: RHEA:14421
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047416
name: arylalkyl acylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN]
synonym: "aralkyl acylamidase activity" RELATED [EC:3.5.1.76]
synonym: "N-acetylarylalkylamine amidohydrolase activity" RELATED [EC:3.5.1.76]
xref: EC:3.5.1.76
xref: MetaCyc:3.5.1.76-RXN
xref: RHEA:10352
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047417
name: N-carbamoyl-D-amino acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN]
synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" RELATED [EC:3.5.1.77]
xref: EC:3.5.1.77
xref: MetaCyc:3.5.1.77-RXN
xref: RHEA:11000
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047418
name: phthalyl amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN]
synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79]
synonym: "phthalyl-amide amidohydrolase activity" RELATED [EC:3.5.1.79]
xref: EC:3.5.1.79
xref: MetaCyc:3.5.1.79-RXN
xref: RHEA:18297
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047419
name: N-acetylgalactosamine-6-phosphate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [RHEA:18149]
xref: MetaCyc:3.5.1.80-RXN
xref: RHEA:18149
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047420
name: N-acyl-D-amino-acid deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN]
synonym: "D-aminoacylase activity" RELATED [EC:3.5.1.81]
synonym: "N-acyl-D-amino acid amidohydrolase activity" RELATED [EC:3.5.1.81]
xref: EC:3.5.1.81
xref: MetaCyc:3.5.1.81-RXN
xref: RHEA:18309
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047421
name: N-acyl-D-glutamate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-glutamate + H2O = D-glutamate + a carboxylate." [EC:3.5.1.82, RHEA:12833]
synonym: "N-acyl-D-glutamate amidohydrolase activity" RELATED [EC:3.5.1.82]
xref: EC:3.5.1.82
xref: KEGG_REACTION:R01581
xref: MetaCyc:3.5.1.82-RXN
xref: RHEA:12833
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047422
name: N-acyl-D-aspartate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate." [EC:3.5.1.83, RHEA:18285]
synonym: "N-acyl-D-aspartate amidohydrolase activity" RELATED [EC:3.5.1.83]
xref: EC:3.5.1.83
xref: KEGG_REACTION:R02182
xref: MetaCyc:3.5.1.83-RXN
xref: RHEA:18285
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047423
name: N-methylhydantoinase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylhydantoin + ATP + 2 H2O = N-carbamoylsarcosine + ADP + 3 H+ + phosphate." [EC:3.5.2.14, RHEA:11720]
synonym: "methylhydantoin amidase activity" RELATED [EC:3.5.2.14]
synonym: "N-methylhydantoin amidohydrolase activity" RELATED [EC:3.5.2.14]
synonym: "N-methylhydantoin hydrolase activity" RELATED [EC:3.5.2.14]
synonym: "N-methylhydantoinase (ATP-hydrolysing)" RELATED [EC:3.5.2.14]
synonym: "N-methylhydantoinase activity" RELATED [EC:3.5.2.14]
synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" RELATED [EC:3.5.2.14]
xref: EC:3.5.2.14
xref: KEGG_REACTION:R03187
xref: MetaCyc:3.5.2.14-RXN
xref: RHEA:11720
xref: Wikipedia:N-methylhydantoinase_(ATP-hydrolysing)
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047424
name: methylenediurea deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN, RHEA:15929]
synonym: "methylenediurea aminohydrolase activity" RELATED [EC:3.5.3.21]
synonym: "methylenediurease activity" RELATED [EC:3.5.3.21]
xref: EC:3.5.3.21
xref: MetaCyc:3.5.3.21-RXN
xref: RHEA:15929
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047425
name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H2O + H+ = 2,5-dioxopentanoate + NH4." [EC:3.5.4.22, RHEA:10560]
synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" RELATED [EC:3.5.4.22]
synonym: "HPC deaminase activity" RELATED [EC:3.5.4.22]
xref: EC:3.5.4.22
xref: KEGG_REACTION:R02280
xref: MetaCyc:3.5.4.22-RXN
xref: RHEA:10560
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047426
name: ricinine nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2]
synonym: "ricinine aminohydrolase activity" RELATED [EC:3.5.5.2]
xref: EC:3.5.5.2
xref: MetaCyc:3.5.5.2-RXN
xref: RHEA:22704
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047427
name: cyanoalanine nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-cyano-L-alanine + 2 H2O + H+ = L-aspartate + NH4." [RHEA:11188]
synonym: "3-cyano-L-alanine aminohydrolase activity" RELATED [EC:3.5.5.4]
synonym: "beta-cyanoalanine nitrilase activity" RELATED [EC:3.5.5.4]
xref: EC:3.5.5.4
xref: KEGG_REACTION:R00486
xref: MetaCyc:3.5.5.4-RXN
xref: RHEA:11188
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047428
name: arylacetonitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5]
synonym: "arylacetonitrile aminohydrolase activity" RELATED [EC:3.5.5.5]
xref: EC:3.5.5.5
xref: MetaCyc:3.5.5.5-RXN
xref: RHEA:20657
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047429
name: nucleoside triphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]
synonym: "nucleoside-triphosphate diphosphatase activity" EXACT []
synonym: "nucleoside-triphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.9]
synonym: "nucleoside-triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.9]
xref: EC:3.6.1.9
xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN
xref: Reactome:R-HSA-9755030 "ITPA dimer dephosphorylates RBV-TP to RBV-MP"
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047430
name: oligosaccharide-diphosphodolichol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN]
synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" RELATED [EC:3.6.1.44]
synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT []
xref: EC:3.6.1.44
xref: MetaCyc:3.6.1.44-RXN
xref: RHEA:15205
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047431
name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H+ = 5-hydroxy-6-methylpyridine-3-carboxylate + CO2." [EC:4.1.1.51, RHEA:13669]
synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" RELATED [EC:4.1.1.51]
synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" RELATED [EC:4.1.1.51]
xref: EC:4.1.1.51
xref: KEGG_REACTION:R03461
xref: MetaCyc:4.1.1.51-RXN
xref: RHEA:13669
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047432
name: 2,2-dialkylglycine decarboxylase (pyruvate) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2-dialkylglycine + H+ + pyruvate = L-alanine + CO2 + dialkyl ketone." [EC:4.1.1.64, RHEA:16073]
synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" RELATED [EC:4.1.1.64]
synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" RELATED [EC:4.1.1.64]
synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" RELATED [EC:4.1.1.64]
synonym: "alpha-dialkyl amino acid transaminase activity" RELATED [EC:4.1.1.64]
synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" RELATED [EC:4.1.1.64]
synonym: "dialkylamino-acid decarboxylase (pyruvate)" RELATED [EC:4.1.1.64]
synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" RELATED [EC:4.1.1.64]
xref: EC:4.1.1.64
xref: KEGG_REACTION:R03854
xref: MetaCyc:4.1.1.64-RXN
xref: RHEA:16073
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047433
name: branched-chain-2-oxoacid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H+ = 2-methylbutanal + CO2." [EC:4.1.1.72, RHEA:21108]
synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" RELATED [EC:4.1.1.72]
synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" RELATED [EC:4.1.1.72]
synonym: "BCKA" RELATED [EC:4.1.1.72]
synonym: "branched-chain alpha-keto acid decarboxylase activity" RELATED [EC:4.1.1.72]
synonym: "branched-chain keto acid decarboxylase activity" RELATED [EC:4.1.1.72]
synonym: "branched-chain oxo acid decarboxylase activity" RELATED [EC:4.1.1.72]
xref: EC:4.1.1.72
xref: KEGG_REACTION:R03894
xref: MetaCyc:4.1.1.72-RXN
xref: RHEA:21108
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047434
name: indolepyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN]
synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74]
synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" RELATED [EC:4.1.1.74]
synonym: "indol-3-yl-pyruvate carboxy-lyase activity" RELATED [EC:4.1.1.74]
synonym: "indole-3-pyruvate decarboxylase activity" RELATED [EC:4.1.1.74]
xref: EC:4.1.1.74
xref: MetaCyc:4.1.1.74-RXN
xref: RHEA:18017
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047435
name: 5-guanidino-2-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2." [EC:4.1.1.75, RHEA:11340]
synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" RELATED [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" RELATED [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" RELATED [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" RELATED [EC:4.1.1.75]
synonym: "alpha-ketoarginine decarboxylase activity" RELATED [EC:4.1.1.75]
xref: EC:4.1.1.75
xref: KEGG_REACTION:R03178
xref: MetaCyc:4.1.1.75-RXN
xref: RHEA:11340
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047436
name: arylmalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aryl-2-methylmalonate + H+ = 2-arylpropionate + CO2." [EC:4.1.1.76, RHEA:20513]
synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" RELATED [EC:4.1.1.76]
synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" RELATED [EC:4.1.1.76]
synonym: "AMDASE" RELATED [EC:4.1.1.76]
synonym: "AMDase activity" RELATED [EC:4.1.1.76]
xref: EC:4.1.1.76
xref: KEGG_REACTION:R05173
xref: MetaCyc:4.1.1.76-RXN
xref: RHEA:20513
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047437
name: 4-oxalocrotonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN]
synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" RELATED [EC:4.1.1.77]
synonym: "4-oxalocrotonate carboxy-lyase activity" RELATED [EC:4.1.1.77]
xref: EC:4.1.1.77
xref: MetaCyc:4.1.1.77-RXN
xref: RHEA:24260
xref: UM-BBD_reactionID:r1435
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047438
name: 2-dehydro-3-deoxy-L-pentonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN]
synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.18]
synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" RELATED [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" RELATED [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" RELATED [EC:4.1.2.18]
synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18]
xref: EC:4.1.2.18
xref: MetaCyc:4.1.2.18-RXN
xref: RHEA:18545
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047439
name: 3-deoxy-D-manno-octulosonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, RHEA:23340]
synonym: "2-keto-3-deoxyoctonate aldolase activity" RELATED [EC:4.1.2.23]
synonym: "2-keto-3-deoxyoctonic aldolase activity" RELATED [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" RELATED [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" RELATED [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonic aldolase activity" RELATED [EC:4.1.2.23]
synonym: "3-deoxyoctulosonic aldolase activity" RELATED [EC:4.1.2.23]
synonym: "KDOaldolase activity" RELATED [EC:4.1.2.23]
xref: EC:4.1.2.23
xref: KEGG_REACTION:R01576
xref: MetaCyc:4.1.2.23-RXN
xref: RHEA:23340
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047440
name: 2-dehydro-3-deoxy-D-pentonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, RHEA:20609]
synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" RELATED [EC:4.1.2.28]
synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" RELATED [EC:4.1.2.28]
synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28]
xref: EC:4.1.2.28
xref: KEGG_REACTION:R01782
xref: MetaCyc:4.1.2.28-RXN
xref: RHEA:20609
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047441
name: 5-dehydro-2-deoxyphosphogluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate." [EC:4.1.2.29, RHEA:13177]
synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.29]
synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" RELATED [EC:4.1.2.29]
synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" RELATED [EC:4.1.2.29]
synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" RELATED [EC:4.1.2.29]
xref: EC:4.1.2.29
xref: KEGG_REACTION:R05378
xref: MetaCyc:4.1.2.29-RXN
xref: RHEA:13177
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047442
name: obsolete 17-alpha-hydroxyprogesterone aldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [GOC:curators]
comment: The reason for obsoletion is that the term is a unnecessarily specific reaction of GO:0004508 steroid 17-alpha-monooxygenase activity.
is_obsolete: true
replaced_by: GO:0004508

[Term]
id: GO:0047443
name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reactions: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate." [EC:4.1.3.17]
synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" RELATED [EC:4.1.3.17]
synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" RELATED [EC:4.1.3.17]
synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" RELATED [EC:4.1.3.17]
synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" RELATED [EC:4.1.3.17]
synonym: "pyruvate aldolase activity" RELATED [EC:4.1.3.17]
xref: EC:4.1.3.17
xref: MetaCyc:4.1.3.17-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047444
name: N-acylneuraminate-9-phosphate synthase activity
namespace: molecular_function
alt_id: GO:0019007
def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57]
synonym: "N-acetylneuraminate 9-phosphate lyase activity" RELATED [EC:2.5.1.57]
synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" RELATED [EC:2.5.1.57]
synonym: "N-acetylneuraminate 9-phosphate synthetase activity" RELATED [EC:2.5.1.57]
synonym: "N-acetylneuraminic acid phosphate synthase activity" EXACT [GOC:mah]
synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.57]
synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" RELATED [EC:2.5.1.57]
synonym: "sialic acid 9-phosphate synthetase activity" RELATED [EC:2.5.1.57]
xref: EC:2.5.1.57
xref: MetaCyc:RXN-9988
xref: Reactome:R-HSA-4084976 "NANS converts ManNAc-6-P to Neu5Ac-9-P"
xref: RHEA:13421
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047445
name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H+ = 7-methyl-3-oxooct-6-enoyl-CoA + acetate." [EC:4.1.3.26, RHEA:23084]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" RELATED [EC:4.1.3.26]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" RELATED [EC:4.1.3.26]
synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" RELATED [EC:4.1.3.26]
synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" RELATED [EC:4.1.3.26]
synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" RELATED [EC:4.1.3.26]
synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" RELATED [EC:4.1.3.26]
xref: EC:4.1.3.26
xref: KEGG_REACTION:R08090
xref: MetaCyc:4.1.3.26-RXN
xref: RHEA:23084
xref: UM-BBD_reactionID:r1168
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047446
name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone." [EC:4.1.3.35, RHEA:23868]
synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.35]
synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" RELATED [EC:4.1.3.35]
xref: EC:4.1.3.35
xref: KEGG_REACTION:R02232
xref: MetaCyc:4.1.3.35-RXN
xref: RHEA:23868
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047447
name: erythro-3-hydroxyaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN]
synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" RELATED [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" RELATED [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" RELATED [EC:4.3.1.20]
synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT []
synonym: "erythro-beta-hydroxyaspartate dehydratase activity" RELATED [EC:4.3.1.20]
xref: EC:4.3.1.20
xref: MetaCyc:4.3.1.20-RXN
xref: RHEA:19757
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047448
name: 5-dehydro-4-deoxyglucarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H+ = 2,5-dioxopentanoate + CO2 + H2O." [EC:4.2.1.41, RHEA:24608]
synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" RELATED [EC:4.2.1.41]
synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" RELATED [EC:4.2.1.41]
synonym: "5-keto-4-deoxy-glucarate dehydratase activity" RELATED [EC:4.2.1.41]
synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" RELATED [EC:4.2.1.41]
synonym: "deoxyketoglucarate dehydratase activity" RELATED [EC:4.2.1.41]
xref: EC:4.2.1.41
xref: KEGG_REACTION:R02279
xref: MetaCyc:4.2.1.41-RXN
xref: RHEA:24608
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047449
name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O." [EC:4.2.1.43, RHEA:17201]
synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" RELATED [EC:4.2.1.43]
synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" RELATED [EC:4.2.1.43]
synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" RELATED [EC:4.2.1.43]
xref: EC:4.2.1.43
xref: KEGG_REACTION:R02278
xref: MetaCyc:4.2.1.43-RXN
xref: RHEA:17201
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047450
name: obsolete (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
namespace: molecular_function
alt_id: GO:0080063
def: "OBSOLETE. Catalysis of the reaction: (3R)-hydroxybutanoyl-[acyl-carrier-protein] = (2E)-butenoyl-[acyl-carrier-protein] + H2O." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity ; GO:0019171.
synonym: "(3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity" EXACT []
synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT []
synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT []
synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT []
synonym: "crotonoyl-[acyl-carrier-protein] hydratase activity" EXACT []
synonym: "crotonoyl-ACP hydratase activity" EXACT []
synonym: "crotonoyl-acyl-carrier-protein hydratase activity" EXACT []
synonym: "crotonyl acyl carrier protein hydratase activity" EXACT []
is_obsolete: true
replaced_by: GO:0019171

[Term]
id: GO:0047451
name: obsolete (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + (2E)-octenoyl-[acyl-carrier protein]." [PMID:8910376]
comment: This term was obsoleted because it represents a specific substrate of (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity ; GO:0019171.
synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" RELATED []
synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity" BROAD []
synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT []
is_obsolete: true
replaced_by: GO:0019171

[Term]
id: GO:0047452
name: protoaphin-aglucone dehydratase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin." [EC:4.2.1.73, RHEA:23876]
synonym: "protoaphin dehydratase (cyclizing)" RELATED [EC:4.2.1.73]
synonym: "protoaphin dehydratase activity" RELATED [EC:4.2.1.73]
synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" RELATED [EC:4.2.1.73]
synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" RELATED [EC:4.2.1.73]
xref: EC:4.2.1.73
xref: KEGG_REACTION:R03742
xref: MetaCyc:4.2.1.73-RXN
xref: RHEA:23876
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047453
name: ATP-dependent NAD(P)H-hydrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + H+ + NAD(P)H + phosphate." [EC:4.2.1.93, PMID:3061454]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" RELATED [EC:4.2.1.93]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93]
synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT []
synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD [EC:4.2.1.93]
xref: EC:4.2.1.93
xref: KEGG_REACTION:R00129
xref: MetaCyc:4.2.1.93-RXN
xref: Reactome:R-HSA-6806967 "CARKD dehydrates S-NAD(P)HX to NADPH"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047454
name: phaseollidin hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin." [EC:4.2.1.97, RHEA:19769]
synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" RELATED [EC:4.2.1.97]
synonym: "phaseollidin-hydrate hydro-lyase activity" RELATED [EC:4.2.1.97]
xref: EC:4.2.1.97
xref: KEGG_REACTION:R04728
xref: MetaCyc:4.2.1.97-RXN
xref: RHEA:19769
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047455
name: 16-alpha-hydroxyprogesterone dehydratase activity
namespace: molecular_function
alt_id: GO:0047523
def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN]
synonym: "16-alpha-dehydroxylase activity" RELATED [EC:4.2.1.98]
synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" RELATED [EC:4.2.1.98]
synonym: "16-dehydroprogesterone hydratase activity" RELATED []
synonym: "16alpha-dehydroxylase activity" RELATED [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone dehydratase activity" RELATED [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" RELATED [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" RELATED [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" RELATED [EC:4.2.1.98]
synonym: "hydroxyprogesterone dehydroxylase activity" EXACT []
xref: EC:4.2.1.98
xref: MetaCyc:4.2.1.98-RXN
xref: RHEA:12584
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047456
name: 2-methylisocitrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H2O." [EC:4.2.1.99, RHEA:17941]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" RELATED [EC:4.2.1.99]
xref: EC:4.2.1.99
xref: KEGG_REACTION:R04425
xref: MetaCyc:4.2.1.99-RXN
xref: RHEA:17941
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047457
name: exo-(1,4)-alpha-D-glucan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN]
synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" RELATED [EC:4.2.2.13]
synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" RELATED [EC:4.2.2.13]
synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" RELATED [EC:4.2.2.13]
synonym: "alpha-1,4-glucan exo-lyase activity" RELATED [EC:4.2.2.13]
synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13]
synonym: "exo-(1->4)-alpha-D-glucan lyase activity" RELATED [EC:4.2.2.13]
synonym: "exo-alpha-1,4-glucan lyase activity" RELATED [EC:4.2.2.13]
xref: EC:4.2.2.13
xref: MetaCyc:4.2.2.13-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047458
name: beta-pyrazolylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H+." [RHEA:13117]
synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.51]
synonym: "beta-(1-pyrazolyl)alanine synthase activity" RELATED [EC:2.5.1.51]
synonym: "beta-pyrazolealanine synthase activity" RELATED [EC:2.5.1.51]
synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT []
synonym: "BPA-synthase activity" RELATED [EC:2.5.1.51]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" RELATED [EC:2.5.1.51]
synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" RELATED [EC:2.5.1.51]
synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.51]
synonym: "pyrazolealanine synthase activity" RELATED [EC:2.5.1.51]
synonym: "pyrazolylalaninase activity" RELATED [EC:2.5.1.51]
xref: EC:2.5.1.51
xref: KEGG_REACTION:R03134
xref: MetaCyc:2.5.1.51-RXN
xref: RHEA:13117
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047459
name: 3-aminobutyryl-CoA ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH4." [EC:4.3.1.14, RHEA:10056]
synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" RELATED [EC:4.3.1.14]
synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" RELATED [EC:4.3.1.14]
synonym: "L-3-aminobutyryl-CoA deaminase activity" RELATED [EC:4.3.1.14]
xref: EC:4.3.1.14
xref: KEGG_REACTION:R03030
xref: MetaCyc:4.3.1.14-RXN
xref: RHEA:10056
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047460
name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + H+ + NH4." [EC:4.5.1.4, RHEA:11620]
synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" RELATED [EC:4.5.1.4]
synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" RELATED [EC:4.5.1.4]
synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" RELATED [EC:4.5.1.4]
xref: EC:4.5.1.4
xref: KEGG_REACTION:R02605
xref: MetaCyc:4.5.1.4-RXN
xref: RHEA:11620
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0047461
name: (+)-delta-cadinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" RELATED [EC:4.2.3.13]
synonym: "D-cadinene synthase activity" RELATED [EC:4.2.3.13]
xref: EC:4.2.3.13
xref: MetaCyc:4.6.1.11-RXN
xref: RHEA:19525
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0047462
name: phenylalanine racemase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + 2 H+." [EC:5.1.1.11, RHEA:20201]
synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11]
synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" RELATED [EC:5.1.1.11]
synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11]
synonym: "phenylalanine racemase activity" RELATED [EC:5.1.1.11]
xref: EC:5.1.1.11
xref: KEGG_REACTION:R00686
xref: MetaCyc:5.1.1.11-RXN
xref: RHEA:20201
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047463
name: 2-aminohexano-6-lactam racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam." [EC:5.1.1.15, RHEA:14813]
synonym: "2-amino-hexano-6-lactam racemase activity" RELATED [EC:5.1.1.15]
synonym: "alpha-amino-epsilon-caprolactam racemase activity" RELATED [EC:5.1.1.15]
xref: EC:5.1.1.15
xref: KEGG_REACTION:R04736
xref: MetaCyc:5.1.1.15-RXN
xref: RHEA:14813
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0047464
name: heparosan-N-sulfate-glucuronate 5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (heparosan-N-sulfate)(n) = (heparan-N-sulfate)(n). Converts D-glucosyluronate residues to L-iduronate residues." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]
synonym: "C-5 uronosyl epimerase activity" RELATED [EC:5.1.3.17]
synonym: "D-glucuronyl C-5 epimerase activity" RELATED [EC:5.1.3.17]
synonym: "heparosan epimerase activity" RELATED [EC:5.1.3.17]
synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" RELATED [EC:5.1.3.17]
synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT []
synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" RELATED [EC:5.1.3.17]
synonym: "polyglucuronate epimerase activity" RELATED [EC:5.1.3.17]
xref: EC:5.1.3.17
xref: MetaCyc:5.1.3.17-RXN
xref: Reactome:R-HSA-2024100 "GLCE epimerises GlcA to IdoA"
xref: Reactome:R-HSA-2076371 "GLCE epimerises more GlcA to IdoA as sulfate content rises"
xref: RHEA:20197
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047465
name: N-acylglucosamine-6-phosphate 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate." [RHEA:23932]
synonym: "acylglucosamine phosphate 2-epimerase activity" RELATED [EC:5.1.3.9]
synonym: "acylglucosamine-6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9]
synonym: "acylmannosamine phosphate 2-epimerase activity" RELATED [EC:5.1.3.9]
synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9]
synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9]
synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9]
xref: EC:5.1.3.9
xref: MetaCyc:5.1.3.9-RXN
xref: RHEA:23932
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047466
name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity
namespace: molecular_function
alt_id: GO:0018840
def: "Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide." [EC:5.2.1.10, RHEA:10924]
synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" RELATED [EC:5.2.1.10]
synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" RELATED [EC:5.2.1.-]
synonym: "chlorodienelactone isomerase activity" RELATED [EC:5.2.1.-]
xref: EC:5.2.1.10
xref: KEGG_REACTION:R04576
xref: MetaCyc:5.2.1.10-RXN
xref: RHEA:10924
xref: UM-BBD_reactionID:r0278
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047467
name: obsolete 4-hydroxyphenylacetaldehyde-oxime isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN]
comment: The reason for obsoletion is that this term was based on an EC that has been obsoleted. "The existence of this enzyme has been called into question by one of the authors of the reference cited".
is_obsolete: true

[Term]
id: GO:0047468
name: phosphoglucomutase (glucose-cofactor) activity
namespace: molecular_function
def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5]
synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" RELATED [EC:5.4.2.5]
synonym: "glucose-1-phosphate phosphotransferase activity" RELATED [EC:5.4.2.5]
xref: EC:5.4.2.5
xref: MetaCyc:RXN-16999
is_a: GO:0004614 ! phosphoglucomutase activity

[Term]
id: GO:0047469
name: 4-carboxymethyl-4-methylbutenolide mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, RHEA:19237]
synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" RELATED [EC:5.4.99.14]
synonym: "4-methyl-2-enelactone isomerase activity" RELATED [EC:5.4.99.14]
synonym: "4-methyl-2-enelactone methyl-isomerase activity" RELATED [EC:5.4.99.14]
synonym: "4-methyl-3-enelactone methyl isomerase activity" RELATED [EC:5.4.99.14]
synonym: "4-methylmuconolactone methylisomerase activity" RELATED [EC:5.4.99.14]
xref: EC:5.4.99.14
xref: KEGG_REACTION:R04510
xref: MetaCyc:5.4.99.14-RXN
xref: RHEA:19237
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047470
name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN]
synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15]
synonym: "malto-oligosyltrehalose synthase activity" RELATED [EC:5.4.99.15]
synonym: "maltodextrin alpha-D-glucosyltransferase activity" RELATED [EC:5.4.99.15]
xref: EC:5.4.99.15
xref: MetaCyc:5.4.99.15-RXN
xref: RHEA:13621
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047471
name: maltose alpha-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN]
synonym: "maltose alpha-D-glucosylmutase activity" RELATED [EC:5.4.99.16]
synonym: "maltose glucosylmutase activity" RELATED [EC:5.4.99.16]
synonym: "trehalose synthase activity" RELATED [EC:5.4.99.16]
xref: EC:5.4.99.16
xref: MetaCyc:5.4.99.16-RXN
xref: RHEA:15145
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047472
name: 3-carboxy-cis,cis-muconate cycloisomerase activity
namespace: molecular_function
alt_id: GO:0018842
def: "Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+." [PMID:15301541, PMID:17054713, RHEA:23656]
synonym: "3-carboxymuconate cycloisomerase type II activity" RELATED []
synonym: "3-carboxymuconate lactonizing enzyme activity" RELATED [EC:5.5.1.2]
synonym: "3-carboxymuconolactone hydrolase activity" RELATED []
synonym: "beta-carboxymuconate lactonizing enzyme activity" RELATED [EC:5.5.1.2]
synonym: "CMLE activity" RELATED [EC:5.5.1.2]
xref: EC:5.5.1.2
xref: KEGG_REACTION:R03307
xref: MetaCyc:5.5.1.2-RXN
xref: RHEA:23656
xref: UM-BBD_reactionID:r0582
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047473
name: D-alanine [D-alanyl carrier protein] ligase activity
namespace: molecular_function
def: "Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate." [GOC:pg]
synonym: "D-alanine-activating enzyme activity" RELATED []
synonym: "D-alanine-D-alanyl carrier protein ligase activity" RELATED []
synonym: "D-alanine-poly(phosphoribitol) ligase activity" BROAD []
synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" BROAD []
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047474
name: long-chain fatty acid--protein ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19]
synonym: "long-chain fatty acid luciferin component ligase activity" EXACT []
synonym: "long-chain-fatty-acid luciferin component ligase activity" EXACT [GOC:mah]
synonym: "long-chain-fatty-acid-luciferin-component ligase activity" EXACT []
synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" RELATED [EC:6.2.1.19]
xref: EC:6.2.1.19
xref: MetaCyc:6.2.1.19-RXN
xref: RHEA:20101
is_a: GO:0015645 ! fatty acid ligase activity

[Term]
id: GO:0047475
name: phenylacetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA." [RHEA:20956]
synonym: "PA-CoA ligase activity" RELATED [EC:6.2.1.30]
synonym: "phenacyl coenzyme A synthetase activity" RELATED [EC:6.2.1.30]
synonym: "phenylacetate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.30]
synonym: "phenylacetyl-CoA ligase (AMP-forming)" RELATED [EC:6.2.1.30]
synonym: "phenylacetyl-CoA ligase activity" RELATED [EC:6.2.1.30]
xref: EC:6.2.1.30
xref: KEGG_REACTION:R02539
xref: MetaCyc:RXN-10819
xref: RHEA:20956
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047476
name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" RELATED [EC:6.2.1.28]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.28]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.28]
synonym: "DHCA-CoA ligase activity" RELATED [EC:6.2.1.28]
xref: EC:6.2.1.28
xref: MetaCyc:6.2.1.28-RXN
xref: RHEA:21776
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047478
name: aspartate-ammonia ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + ATP + NH4 = L-asparagine + ADP + 2 H+ + phosphate." [EC:6.3.1.4, RHEA:14197]
synonym: "asparagine synthetase (adenosine diphosphate-forming)" RELATED [EC:6.3.1.4]
synonym: "asparagine synthetase (ADP-forming) activity" RELATED [EC:6.3.1.4]
synonym: "L-aspartate:ammonia ligase (ADP-forming)" RELATED [EC:6.3.1.4]
xref: EC:6.3.1.4
xref: KEGG_REACTION:R00482
xref: MetaCyc:6.3.1.4-RXN
xref: RHEA:14197
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047479
name: trypanothione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN]
synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" RELATED [EC:6.3.1.9]
synonym: "TSR synthetase activity" RELATED [EC:6.3.1.9]
xref: EC:6.3.1.9
xref: MetaCyc:6.3.1.9-RXN
xref: RHEA:21532
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047480
name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10]
comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766).
synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-MurNAc-pentapeptide synthetase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT []
synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT []
synonym: "UDPacetylmuramoylpentapeptide synthetase activity" RELATED [EC:6.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" RELATED [EC:6.3.2.10]
xref: EC:6.3.2.10
xref: MetaCyc:6.3.2.10-RXN
xref: RHEA:16085
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047481
name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN]
synonym: "D-alanine-membrane acceptor-ligase activity" RELATED [EC:6.3.2.16]
synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" RELATED [EC:6.3.2.16]
synonym: "D-alanine:membrane-acceptor ligase activity" RELATED [EC:6.3.2.16]
synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" RELATED [EC:6.3.2.16]
synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" RELATED [EC:6.3.2.16]
synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" RELATED [EC:6.3.2.16]
xref: EC:6.3.2.16
xref: MetaCyc:6.3.2.16-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047482
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine." [EC:6.3.2.7, RHEA:17969]
synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7]
synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.7]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" RELATED [EC:6.3.2.7]
synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" RELATED [EC:6.3.2.7]
synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" RELATED [EC:6.3.2.7]
xref: EC:6.3.2.7
xref: KEGG_REACTION:R02786
xref: MetaCyc:6.3.2.7-RXN
xref: RHEA:17969
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047483
name: imidazoleacetate-phosphoribosyldiphosphate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H+ + phosphate." [EC:6.3.4.8, RHEA:16485]
synonym: "5-phosphoribosylimidazoleacetate synthetase activity" RELATED [EC:6.3.4.8]
synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" RELATED [EC:6.3.4.8]
xref: EC:6.3.4.8
xref: KEGG_REACTION:R04068
xref: MetaCyc:6.3.4.8-RXN
xref: RHEA:16485
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047484
name: regulation of response to osmotic stress
namespace: biological_process
def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0006970 ! response to osmotic stress

[Term]
id: GO:0047485
name: obsolete protein N-terminus binding
namespace: molecular_function
def: "OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]
comment: It is out of GO scope.
synonym: "amino-terminal binding" RELATED [GOC:jsg]
synonym: "amino-terminus binding" RELATED [GOC:jsg]
synonym: "N-terminal binding" EXACT []
synonym: "N-terminal end binding" EXACT [GOC:jsg]
synonym: "NH2-terminal binding" NARROW [GOC:jsg]
synonym: "NH2-terminus binding" NARROW [GOC:jsg]
is_obsolete: true
replaced_by: GO:0005515

[Term]
id: GO:0047486
name: obsolete chondroitin ABC lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [GOC:hjd]
comment: This term represents an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0047487
name: oligogalacturonide lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN]
synonym: "OGTE" RELATED [EC:4.2.2.6]
synonym: "oligogalacturonate lyase activity" RELATED [EC:4.2.2.6]
synonym: "unsaturated oligogalacturonate transeliminase activity" RELATED [EC:4.2.2.6]
xref: EC:4.2.2.6
xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN
xref: RHEA:20269
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047488
name: heparin lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN]
synonym: "heparan sulfate lyase activity" RELATED []
synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7]
synonym: "heparinase activity" RELATED [EC:4.2.2.7]
xref: EC:4.2.2.7
xref: MetaCyc:4.2.2.7-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047489
name: pectate disaccharide-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9]
synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" RELATED [EC:4.2.2.9]
synonym: "exo-PATE" RELATED [EC:4.2.2.9]
synonym: "Exo-PATE activity" RELATED [EC:4.2.2.9]
synonym: "exo-PGL" RELATED [EC:4.2.2.9]
synonym: "Exo-PGL activity" RELATED [EC:4.2.2.9]
synonym: "exopectate lyase activity" RELATED [EC:4.2.2.9]
synonym: "exopectic acid transeliminase activity" RELATED [EC:4.2.2.9]
synonym: "exopolygalacturonate lyase activity" RELATED [EC:4.2.2.9]
synonym: "exopolygalacturonic acid-trans-eliminase activity" RELATED [EC:4.2.2.9]
synonym: "PATE activity" RELATED [EC:4.2.2.9]
synonym: "pectate exo-lyase activity" RELATED [EC:4.2.2.9]
xref: EC:4.2.2.9
xref: MetaCyc:4.2.2.9-RXN
xref: RHEA:57104
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047490
name: pectin lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10]
synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" RELATED [EC:4.2.2.10]
synonym: "endo-pectin lyase activity" RELATED [EC:4.2.2.10]
synonym: "pectin methyltranseliminase activity" RELATED [EC:4.2.2.10]
synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10]
synonym: "pectolyase activity" RELATED [EC:4.2.2.10]
synonym: "PL activity" RELATED [EC:4.2.2.10]
synonym: "PMGL activity" RELATED [EC:4.2.2.10]
synonym: "PNL activity" RELATED [EC:4.2.2.10]
synonym: "polymethylgalacturonic transeliminase activity" RELATED [EC:4.2.2.10]
xref: EC:4.2.2.10
xref: MetaCyc:RXN-19781
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047491
name: poly(alpha-L-guluronate) lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11]
synonym: "alginase II activity" RELATED [EC:4.2.2.11]
synonym: "guluronate lyase activity" RELATED [EC:4.2.2.11]
synonym: "L-guluronan lyase activity" RELATED [EC:4.2.2.11]
synonym: "L-guluronate lyase activity" RELATED [EC:4.2.2.11]
synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" RELATED [EC:4.2.2.11]
synonym: "poly-alpha-L-guluronate lyase activity" RELATED [EC:4.2.2.11]
synonym: "polyguluronate-specific alginate lyase activity" RELATED [EC:4.2.2.11]
xref: EC:4.2.2.11
xref: MetaCyc:4.2.2.11-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047492
name: xanthan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12]
xref: EC:4.2.2.12
xref: MetaCyc:4.2.2.12-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047493
name: ceramide cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin." [EC:2.7.8.3, RHEA:16273]
synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.3]
synonym: "phosphorylcholine-ceramide transferase activity" RELATED [EC:2.7.8.3]
xref: EC:2.7.8.3
xref: KEGG_REACTION:R01891
xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN
xref: RHEA:16273
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047494
name: serine-phosphoethanolamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H+." [EC:2.7.8.4, RHEA:22656]
synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" RELATED [EC:2.7.8.4]
synonym: "serine ethanolamine phosphate synthetase activity" RELATED [EC:2.7.8.4]
synonym: "serine ethanolamine phosphodiester synthase activity" RELATED [EC:2.7.8.4]
synonym: "serine ethanolaminephosphotransferase activity" RELATED [EC:2.7.8.4]
synonym: "serine-phosphinico-ethanolamine synthase activity" RELATED [EC:2.7.8.4]
synonym: "serinephosphoethanolamine synthase activity" RELATED [EC:2.7.8.4]
xref: EC:2.7.8.4
xref: KEGG_REACTION:R02563
xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN
xref: RHEA:22656
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047495
name: membrane-oligosaccharide glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21]
synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" RELATED [EC:2.7.8.21]
synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21]
synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21]
xref: EC:2.7.8.21
xref: MetaCyc:PGLYCEROLTRANSII-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047496
name: vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]
synonym: "microtubule-based vesicle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule
is_a: GO:0099518 ! vesicle cytoskeletal trafficking

[Term]
id: GO:0047497
name: mitochondrion transport along microtubule
namespace: biological_process
def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd]
synonym: "mitochondrial migration along microtubule" EXACT []
synonym: "mitochondrial transport along microtubule" EXACT []
is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0047498
name: calcium-dependent phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [PMID:34831185]
synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW []
synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW []
xref: Reactome:R-HSA-111881 "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase"
xref: Reactome:R-HSA-111883 "PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine"
is_a: GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0047499
name: calcium-independent phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [PMID:34831185]
subset: goslim_chembl
synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW []
xref: Reactome:R-HSA-8952251 "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)"
is_a: GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0047500
name: (+)-borneol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-borneol + NAD+ = (1R, 4R)-camphor + H+ + NADH." [RHEA:17329]
synonym: "(+)-borneol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.198]
synonym: "bicyclic monoterpenol dehydrogenase activity" RELATED [EC:1.1.1.198]
xref: EC:1.1.1.198
xref: KEGG_REACTION:R02944
xref: MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN
xref: RHEA:17329
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047501
name: (+)-neomenthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-neomenthol + NADP+ = (2S,5R)-menthone + H+ + NADPH." [EC:1.1.1.208, RHEA:23812]
synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.208]
synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208]
xref: EC:1.1.1.208
xref: KEGG_REACTION:R02548
xref: MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN
xref: RHEA:23812
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047502
name: (+)-sabinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (1S,5S)-sabinone + H+ + NADH." [EC:1.1.1.228, RHEA:18329]
synonym: "(+)-cis-sabinol dehydrogenase activity" RELATED [EC:1.1.1.228]
synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.228]
xref: EC:1.1.1.228
xref: KEGG_REACTION:R03745
xref: MetaCyc:+-SABINOL-DEHYDROGENASE-RXN
xref: RHEA:18329
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047503
name: (-)-borneol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-borneol + NAD+ = (1S,4S)-camphor + H+ + NADH." [EC:1.1.1.227, RHEA:22128]
synonym: "(-)-borneol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.227]
xref: EC:1.1.1.227
xref: KEGG_REACTION:R02945
xref: MetaCyc:--BORNEOL-DEHYDROGENASE-RXN
xref: RHEA:22128
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047504
name: (-)-menthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + NADP+ = (2S,5R)-menthone + H+ + NADPH." [EC:1.1.1.207, RHEA:13917]
synonym: "(-)-menthol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.207]
synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207]
xref: EC:1.1.1.207
xref: KEGG_REACTION:R02177
xref: MetaCyc:--MENTHOL-DEHYDROGENASE-RXN
xref: RHEA:13917
xref: UM-BBD_reactionID:r1182
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047505
name: (-)-menthol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + H+ + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP+." [EC:1.14.13.46, RHEA:11648]
synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" RELATED [EC:1.14.13.46]
synonym: "l-menthol monooxygenase activity" RELATED [EC:1.14.13.46]
xref: EC:1.14.13.46
xref: KEGG_REACTION:R02178
xref: MetaCyc:--MENTHOL-MONOOXYGENASE-RXN
xref: RHEA:11648
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047506
name: (deoxy)adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11]
synonym: "ATP:(d)AMP phosphotransferase activity" RELATED [EC:2.7.4.11]
xref: EC:2.7.4.11
xref: MetaCyc:DEOXYADENYLATE-KINASE-RXN
xref: RHEA:23100
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047507
name: (deoxy)nucleoside-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13]
synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" RELATED [EC:2.7.4.13]
synonym: "deoxynucleoside monophosphate kinase activity" RELATED [EC:2.7.4.13]
synonym: "deoxynucleoside-5'-monophosphate kinase activity" RELATED [EC:2.7.4.13]
synonym: "deoxyribonucleoside monophosphokinase activity" RELATED [EC:2.7.4.13]
xref: EC:2.7.4.13
xref: MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN
xref: RHEA:11216
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0047508
name: (R)-2-methylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H2O." [EC:4.2.1.35]
synonym: "(-)-citramalate hydro-lyase activity" RELATED [EC:4.2.1.35]
synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" RELATED [EC:4.2.1.35]
synonym: "(R)-2-methylmalate hydro-lyase activity" RELATED [EC:4.2.1.35]
synonym: "citraconase activity" RELATED [EC:4.2.1.35]
synonym: "citraconate hydratase activity" RELATED [EC:4.2.1.35]
synonym: "citramalate hydro-lyase activity" RELATED [EC:4.2.1.35]
xref: EC:4.2.1.35
xref: KEGG_REACTION:R03896
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047509
name: (R)-dehydropantoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-4-dehydropantoate + H2O + NAD+ = (R)-3,3-dimethylmalate + 2 H+ + NADH." [EC:1.2.1.33, RHEA:19349]
synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.2.1.33]
synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" RELATED [EC:1.2.1.33]
synonym: "D-aldopantoate dehydrogenase activity" RELATED [EC:1.2.1.33]
xref: EC:1.2.1.33
xref: KEGG_REACTION:R03198
xref: MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN
xref: RHEA:19349
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047510
name: (S)-2-methylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-citramalate = H2O + mesaconate." [RHEA:13529]
synonym: "(+)-citramalate hydro-lyase activity" RELATED [EC:4.2.1.34]
synonym: "(+)-citramalic hydro-lyase activity" RELATED [EC:4.2.1.34]
synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" RELATED [EC:4.2.1.34]
synonym: "(S)-2-methylmalate hydro-lyase activity" RELATED [EC:4.2.1.34]
synonym: "citramalate dehydratase activity" RELATED [EC:4.2.1.34]
synonym: "L-citramalate hydrolase activity" RELATED [EC:4.2.1.34]
synonym: "mesaconase activity" RELATED [EC:4.2.1.34]
synonym: "mesaconate hydratase activity" RELATED [EC:4.2.1.34]
synonym: "mesaconate mesaconase activity" RELATED [EC:4.2.1.34]
xref: EC:4.2.1.34
xref: KEGG_REACTION:R03693
xref: MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN
xref: RHEA:13529
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047511
name: (S)-methylmalonyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = CoA + H+ + methylmalonate." [EC:3.1.2.17, RHEA:17345]
synonym: "D-methylmalonyl-coenzyme A hydrolase activity" RELATED [EC:3.1.2.17]
xref: EC:3.1.2.17
xref: KEGG_REACTION:R02764
xref: MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN
xref: RHEA:17345
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0047512
name: (S,S)-butanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + H+ + NADH." [EC:1.1.1.76, RHEA:12184]
synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.76]
synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" RELATED [EC:1.1.1.76]
synonym: "L-BDH" RELATED [EC:1.1.1.76]
synonym: "L-butanediol dehydrogenase activity" RELATED [EC:1.1.1.76]
xref: EC:1.1.1.76
xref: KEGG_REACTION:R03707
xref: MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN
xref: RHEA:12184
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047513
name: 1,2-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN]
synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" RELATED [EC:3.2.1.63]
synonym: "almond emulsin fucosidase activity" RELATED [EC:3.2.1.63]
synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63]
synonym: "alpha-(1->2)-L-fucosidase activity" RELATED [EC:3.2.1.63]
xref: EC:3.2.1.63
xref: MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN
xref: RHEA:10816
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0047514
name: 1,3-beta-D-glucan phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN]
synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" RELATED [EC:2.4.1.97]
synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.97]
synonym: "1,3-beta-glucan phosphorylase activity" EXACT []
synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97]
synonym: "laminarin phosphoryltransferase activity" RELATED [EC:2.4.1.97]
xref: EC:2.4.1.97
xref: MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047515
name: 1,3-beta-oligoglucan phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN]
synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.30]
synonym: "beta-1,3-oligoglucan phosphorylase activity" RELATED [EC:2.4.1.30]
synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" RELATED [EC:2.4.1.30]
xref: EC:2.4.1.30
xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN
xref: RHEA:16041
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047516
name: 1,3-propanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN]
synonym: "1,3-PD:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.202]
synonym: "1,3-propanediol oxidoreductase activity" RELATED [EC:1.1.1.202]
synonym: "1,3-propanediol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.202]
synonym: "3-hydroxypropionaldehyde reductase activity" RELATED [EC:1.1.1.202]
synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.202]
xref: EC:1.1.1.202
xref: MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN
xref: RHEA:23188
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047517
name: 1,4-beta-D-xylan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1)." [EC:2.4.2.24]
synonym: "1,4-beta-xylan synthase activity" RELATED [EC:2.4.2.24]
synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.24]
synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" RELATED [EC:2.4.2.24]
synonym: "xylan synthase activity" RELATED [EC:2.4.2.24]
synonym: "xylan synthetase activity" RELATED [EC:2.4.2.24]
xref: EC:2.4.2.24
xref: MetaCyc:RXN-9104
xref: RHEA:15289
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0047518
name: 1-methyladenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + ribofuranose." [EC:3.2.2.13, RHEA:12865]
synonym: "1-methyladenosine hydrolase activity" RELATED [EC:3.2.2.13]
synonym: "1-methyladenosine ribohydrolase activity" RELATED [EC:3.2.2.13]
xref: EC:3.2.2.13
xref: KEGG_REACTION:R03885
xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN
xref: RHEA:12865
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047519
name: quinate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol." [RHEA:23672]
synonym: "NAD(P)-independent quinate dehydrogenase activity" RELATED [EC:1.1.5.8]
synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" RELATED [EC:1.1.5.8]
synonym: "quinate:quinone 3-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.8]
xref: EC:1.1.5.8
xref: KEGG_REACTION:R01873
xref: MetaCyc:1.1.99.25-RXN
xref: RHEA:23672
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0047520
name: 11-cis-retinyl-palmitate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + H+ + palmitate." [EC:3.1.1.63, RHEA:19697]
synonym: "11-cis-retinol palmitate esterase activity" RELATED [EC:3.1.1.63]
synonym: "11-cis-retinyl-palmitate acylhydrolase activity" RELATED [EC:3.1.1.63]
synonym: "RPH" RELATED [EC:3.1.1.63]
xref: EC:3.1.1.63
xref: KEGG_REACTION:R03049
xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN
xref: Reactome:R-HSA-2465941 "A REH hydrolyses 11cRE to 11cROL"
xref: RHEA:19697
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047521
name: 12-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-alpha,7-alpha,12-beta-trihydroxy-5-beta-cholanate + NADP+ = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + H+ + NADPH." [RHEA:21424]
synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.238]
synonym: "12beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238]
synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.238]
synonym: "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity" BROAD [EC:1.1.1.238]
xref: EC:1.1.1.238
xref: KEGG_REACTION:R03495
xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
xref: RHEA:21424
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047522
name: 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(P)+ = 15-oxoprostaglandin E2 + H+ + NAD(P)H." [EC:1.3.1.48]
synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" EXACT [EC:1.3.1.48]
synonym: "15-oxo-Delta(13)-prostaglandin reductase activity" EXACT []
synonym: "15-oxoprostaglandin 13-oxidase activity" EXACT []
xref: EC:1.3.1.48
xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN
xref: Reactome:R-HSA-2161692 "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047524
name: 16-hydroxysteroid epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [RHEA:15829]
synonym: "16-hydroxysteroid 16-epimerase activity" RELATED [EC:5.1.99.2]
xref: EC:5.1.99.2
xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN
xref: RHEA:15829
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0047525
name: 2'-hydroxydaidzein reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+." [EC:1.3.1.51]
synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.3.1.51]
synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" RELATED [EC:1.3.1.51]
synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.3.1.51]
synonym: "HDR activity" RELATED [EC:1.3.1.51]
synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" RELATED [EC:1.3.1.51]
xref: EC:1.3.1.51
xref: MetaCyc:RXN-4502
xref: RHEA:17145
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047526
name: 2'-hydroxyisoflavone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [RHEA:22560]
synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" RELATED [EC:1.3.1.45]
synonym: "isoflavone reductase activity" RELATED [EC:1.3.1.45]
synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" RELATED [EC:1.3.1.45]
synonym: "vestitone:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.45]
xref: EC:1.3.1.45
xref: MetaCyc:RXN-3562
xref: RHEA:22560
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047527
name: 2,3-dihydroxybenzoate-serine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14]
synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" RELATED [EC:6.3.2.14]
synonym: "2,3-dihydroxybenzoylserine synthetase activity" RELATED [EC:6.3.2.14]
synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" RELATED [EC:6.3.2.14]
xref: EC:6.3.2.14
xref: MetaCyc:ENTMULTI-RXN
xref: RHEA:30571
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047528
name: 2,3-dihydroxyindole 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2 + H+." [EC:1.13.11.23, RHEA:19445]
synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" RELATED [EC:1.13.11.23]
xref: EC:1.13.11.23
xref: KEGG_REACTION:R00983
xref: MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN
xref: RHEA:19445
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047529
name: 2,3-dimethylmalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, RHEA:10472]
synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" RELATED [EC:4.1.3.32]
synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" RELATED [EC:4.1.3.32]
synonym: "2,3-dimethylmalate pyruvate-lyase activity" RELATED [EC:4.1.3.32]
xref: EC:4.1.3.32
xref: KEGG_REACTION:R01355
xref: MetaCyc:23-DIMETHYLMALATE-LYASE-RXN
xref: RHEA:10472
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047530
name: 2,4-diaminopentanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN]
synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.12]
synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" RELATED [EC:1.4.1.12]
xref: EC:1.4.1.12
xref: MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047531
name: obsolete 2,5-diaminovalerate transaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate." [GOC:curators]
comment: This term was obsoleted because this reaction is not believed to exist.
synonym: "2,5-diaminovalerate aminotransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0047532
name: 2,5-dioxopiperazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine." [EC:3.5.2.13, RHEA:21808]
synonym: "2,5-dioxopiperazine amidohydrolase activity" RELATED [EC:3.5.2.13]
synonym: "cyclo(Gly-Gly) hydrolase activity" RELATED [EC:3.5.2.13]
synonym: "cyclo(glycylglycine) hydrolase activity" RELATED [EC:3.5.2.13]
xref: EC:3.5.2.13
xref: KEGG_REACTION:R03810
xref: MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN
xref: RHEA:21808
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047533
name: 2,5-dioxovalerate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN]
synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" RELATED [EC:1.2.1.26]
synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.26]
synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.26]
xref: EC:1.2.1.26
xref: MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN
xref: RHEA:11296
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047534
name: 2-acetolactate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN]
synonym: "2-acetolactate methylmutase activity" RELATED [EC:5.4.99.3]
synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3]
synonym: "acetolactate mutase activity" RELATED [EC:5.4.99.3]
xref: EC:5.4.99.3
xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN
xref: RHEA:16361
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047535
name: 2-alkyn-1-ol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + H+ + NADH." [EC:1.1.1.165, RHEA:19101]
synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.165]
xref: EC:1.1.1.165
xref: KEGG_REACTION:R03963
xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN
xref: RHEA:19101
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047536
name: 2-aminoadipate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12601]
synonym: "2-aminoadipate aminotransferase activity" EXACT []
synonym: "2-aminoadipic aminotransferase activity" RELATED [EC:2.6.1.39]
synonym: "alpha-aminoadipate aminotransferase activity" RELATED [EC:2.6.1.39]
synonym: "glutamate-alpha-ketoadipate transaminase activity" RELATED [EC:2.6.1.39]
synonym: "glutamic-ketoadipic transaminase activity" RELATED [EC:2.6.1.39]
synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.39]
xref: EC:2.6.1.39
xref: KEGG_REACTION:R01939
xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-508561 "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate"
xref: Reactome:R-HSA-70952 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate"
xref: RHEA:12601
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047537
name: 2-aminohexanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN]
synonym: "2-aminohexanoate aminotransferase activity" EXACT []
synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.67]
synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.67]
synonym: "norleucine (leucine) aminotransferase activity" RELATED [EC:2.6.1.67]
synonym: "norleucine aminotransferase activity" RELATED [EC:2.6.1.67]
synonym: "norleucine transaminase activity" RELATED [EC:2.6.1.67]
xref: EC:2.6.1.67
xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN
xref: RHEA:23600
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047538
name: 2-carboxy-D-arabinitol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, RHEA:17837]
synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.63]
synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.63]
synonym: "2-carboxyarabinitol 1-phosphatase activity" RELATED [EC:3.1.3.63]
xref: EC:3.1.3.63
xref: KEGG_REACTION:R04167
xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN
xref: RHEA:17837
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047539
name: 2-deoxyglucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN]
synonym: "2-deoxy-alpha-D-glucosidase activity" RELATED [EC:3.2.1.112]
synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" RELATED [EC:3.2.1.112]
synonym: "2-deoxy-alpha-glucosidase activity" RELATED [EC:3.2.1.112]
xref: EC:3.2.1.112
xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN
xref: RHEA:15317
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0047540
name: 2-enoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN]
synonym: "butanoate:NAD+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.31]
synonym: "enoate reductase activity" RELATED [EC:1.3.1.31]
xref: EC:1.3.1.31
xref: MetaCyc:2-ENOATE-REDUCTASE-RXN
xref: RHEA:10200
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047541
name: 2-furoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H+." [EC:6.2.1.31, RHEA:19269]
synonym: "2-furoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.31]
synonym: "2-furoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.31]
xref: EC:6.2.1.31
xref: KEGG_REACTION:R02986
xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN
xref: RHEA:19269
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047542
name: 2-furoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH(2) + H+." [EC:1.3.99.8, RHEA:21480]
synonym: "2-furoyl coenzyme A dehydrogenase activity" RELATED [EC:1.3.99.8]
synonym: "2-furoyl coenzyme A hydroxylase activity" RELATED [EC:1.3.99.8]
synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.8]
synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.8]
synonym: "furoyl-CoA hydroxylase activity" RELATED [EC:1.3.99.8]
xref: EC:1.3.99.8
xref: KEGG_REACTION:R02987
xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN
xref: RHEA:21480
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047543
name: 2-hexadecenal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + palmitaldehyde = trans-hexadec-2-enal + H+ + NADPH." [EC:1.3.1.27, RHEA:12444]
synonym: "hexadecanal: NADP+ oxidoreductase activity" RELATED [EC:1.3.1.27]
synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.27]
xref: EC:1.3.1.27
xref: KEGG_REACTION:R02463
xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN
xref: RHEA:12444
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047544
name: 2-hydroxybiphenyl 3-monooxygenase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl-2-ol + H+ + NADH + O2 = biphenyl-2,3-diol + H2O + NAD+. Also converts 2,2'-dihydroxybiphenyl into 2,2',3-trihydroxy-biphenyl." [EC:1.14.13.44]
synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.44]
xref: EC:1.14.13.44
xref: KEGG_REACTION:R03964
xref: UM-BBD_reactionID:r1423
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047545
name: 2-hydroxyglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]
synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" RELATED [EC:1.1.99.2]
synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" RELATED [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate dehydrogenase activity" RELATED [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate oxidoreductase activity" RELATED [EC:1.1.99.2]
synonym: "hydroxyglutaric dehydrogenase activity" RELATED [EC:1.1.99.2]
synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" RELATED [EC:1.1.99.2]
synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2]
xref: EC:1.1.99.2
xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-880050 "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2"
xref: RHEA:21252
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047546
name: 2-hydroxypyridine 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O2 = 2,5-dihydroxypyridine + A + H2O." [EC:1.14.99.26, RHEA:16973]
synonym: "2-hydroxypyridine oxygenase activity" RELATED [EC:1.14.99.26]
synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.99.26]
xref: EC:1.14.99.26
xref: KEGG_REACTION:R03206
xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN
xref: RHEA:16973
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047547
name: 2-methylcitrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H2O." [EC:4.2.1.79, RHEA:17725]
synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79]
synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" RELATED [EC:4.2.1.79]
synonym: "2-methylcitrate hydro-lyase activity" RELATED [EC:4.2.1.79]
synonym: "prpD" RELATED [EC:4.2.1.79]
xref: EC:4.2.1.79
xref: KEGG_REACTION:R04424
xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN
xref: RHEA:17725
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047548
name: 2-methyleneglutarate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, RHEA:13793]
synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" RELATED [EC:5.4.99.4]
synonym: "alpha-methyleneglutarate mutase activity" RELATED [EC:5.4.99.4]
xref: EC:5.4.99.4
xref: KEGG_REACTION:R03908
xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN
xref: RHEA:13793
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047549
name: 2-nitrophenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-nitrophenol + 2 H+ + 2 NADPH + O2 = catechol + H2O + 2 NADP+ + nitrite." [EC:1.14.13.31, RHEA:19457]
synonym: "2-nitrophenol oxygenase activity" RELATED [EC:1.14.13.31]
synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" RELATED [EC:1.14.13.31]
synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31]
xref: EC:1.14.13.31
xref: KEGG_REACTION:R00828
xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN
xref: RHEA:19457
xref: UM-BBD_reactionID:r1494
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047550
name: 2-oxoadipate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + H+ + NADH." [EC:1.1.1.172, RHEA:14793]
synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.172]
synonym: "2-ketoadipate reductase activity" RELATED [EC:1.1.1.172]
synonym: "alpha-ketoadipate reductase activity" RELATED [EC:1.1.1.172]
xref: EC:1.1.1.172
xref: KEGG_REACTION:R01932
xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN
xref: RHEA:14793
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047551
name: 2-oxoaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN]
synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23]
synonym: "2-oxoaldehyde dehydrogenase (NAD+)" RELATED [EC:1.2.1.23]
synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" RELATED [EC:1.2.1.23]
synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23]
synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23]
synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.23]
synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.23]
xref: EC:1.2.1.23
xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN
xref: RHEA:22276
xref: Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+)
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0047552
name: 2-oxoaldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [RHEA:18129]
synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49]
synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" RELATED [EC:1.2.1.49]
synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49]
synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49]
synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.49]
synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.49]
xref: EC:1.2.1.49
xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:18129
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity

[Term]
id: GO:0047553
name: 2-oxoglutarate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN]
synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3]
synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" RELATED [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" RELATED [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3]
synonym: "alpha-ketoglutarate synthase activity" RELATED [EC:1.2.7.3]
synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3]
synonym: "KGOR activity" RELATED [EC:1.2.7.3]
xref: EC:1.2.7.3
xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN
xref: RHEA:17297
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047554
name: 2-pyrone-4,6-dicarboxylate lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H+." [EC:3.1.1.57, RHEA:10644]
synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" RELATED [EC:3.1.1.57]
xref: EC:3.1.1.57
xref: KEGG_REACTION:R04277
xref: MetaCyc:RXN-2462
xref: RHEA:10644
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047555
name: 3',5'-cyclic-GMP phosphodiesterase activity
namespace: molecular_function
alt_id: GO:0004116
def: "Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+." [RHEA:16957]
synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.35]
synonym: "cGMP phosphodiesterase activity" EXACT []
synonym: "cGMP-PDE" RELATED [EC:3.1.4.35]
synonym: "cGMP-specific phosphodiesterase activity" EXACT []
synonym: "cyclic 3',5'-GMP phosphodiesterase activity" RELATED [EC:3.1.4.35]
synonym: "cyclic GMP phosphodiesterase activity" EXACT []
synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.35]
synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" RELATED [EC:3.1.4.35]
synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT []
xref: EC:3.1.4.35
xref: MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN
xref: Reactome:R-HSA-4086392 "PDE6 hydrolyses cGMP to GMP"
xref: Reactome:R-HSA-418456 "cGMP is degraded by PDEs"
xref: Reactome:R-HSA-74059 "PDE6 hydrolyses cGMP to GMP"
xref: RHEA:16957
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0047556
name: 3,4-dihydroxyphthalate decarboxylase activity
namespace: molecular_function
alt_id: GO:0034913
def: "Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.69, RHEA:18601]
synonym: "3,4-dihydroxyphthalate 2-decarboxylase activity" EXACT []
synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" RELATED [EC:4.1.1.69]
synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" RELATED [EC:4.1.1.69]
xref: EC:4.1.1.69
xref: KEGG_REACTION:R01634
xref: MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
xref: RHEA:18601
xref: UM-BBD_reactionID:r1447
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047557
name: 3-aci-nitropropanoate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-aci-nitropropanoate + H2O + O2 = 3-oxopropanoate + H2O2 + nitrite." [EC:1.7.3.5, RHEA:22372]
synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" RELATED [EC:1.7.3.5]
synonym: "propionate-3-nitronate oxidase activity" RELATED [EC:1.7.3.5]
xref: EC:1.7.3.5
xref: KEGG_REACTION:R01609
xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN
xref: RHEA:22372
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047558
name: 3-cyanoalanine hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H2O + H+." [EC:4.2.1.65, RHEA:15385]
synonym: "beta-CNA nitrilase activity" RELATED [EC:4.2.1.65]
synonym: "beta-CNAla hydrolase activity" RELATED [EC:4.2.1.65]
synonym: "beta-cyanoalanine hydratase activity" RELATED [EC:4.2.1.65]
synonym: "beta-cyanoalanine hydrolase activity" RELATED [EC:4.2.1.65]
synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" RELATED [EC:4.2.1.65]
synonym: "L-asparagine hydro-lyase activity" RELATED [EC:4.2.1.65]
xref: EC:4.2.1.65
xref: KEGG_REACTION:R01267
xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN
xref: RHEA:15385
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047559
name: 3-dehydro-L-gulonate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN]
synonym: "2,3-diketo-L-gulonate reductase activity" RELATED [EC:1.1.1.130]
synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.130]
synonym: "3-keto-L-gulonate dehydrogenase activity" RELATED [EC:1.1.1.130]
synonym: "3-ketogulonate dehydrogenase activity" RELATED [EC:1.1.1.130]
xref: EC:1.1.1.130
xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047560
name: 3-dehydrosphinganine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + sphinganine = 3-dehydrosphinganine + H+ + NADPH." [EC:1.1.1.102, RHEA:22640]
synonym: "3-ketosphinganine reductase activity" RELATED [EC:1.1.1.102]
synonym: "3-oxosphinganine reductase activity" RELATED [EC:1.1.1.102]
synonym: "3-oxosphinganine:NADPH oxidoreductase activity" RELATED [EC:1.1.1.102]
synonym: "D-3-dehydrosphinganine reductase activity" RELATED [EC:1.1.1.102]
synonym: "D-3-oxosphinganine reductase activity" RELATED [EC:1.1.1.102]
synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" RELATED [EC:1.1.1.102]
synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.102]
synonym: "DSR activity" RELATED [EC:1.1.1.102]
synonym: "KTS reductase activity" RELATED [EC:1.1.1.102]
xref: EC:1.1.1.102
xref: KEGG_REACTION:R02978
xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN
xref: Reactome:R-HSA-428123 "KDSR reduces 3-ketosphingoid"
xref: RHEA:22640
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047561
name: 3-hydroxyanthranilate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2." [EC:1.10.3.5, RHEA:17245]
synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" RELATED [EC:1.10.3.5]
synonym: "3-hydroxyanthranilic acid oxidase activity" RELATED [EC:1.10.3.5]
xref: EC:1.10.3.5
xref: KEGG_REACTION:R02666
xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN
xref: RHEA:17245
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0047562
name: 3-hydroxyaspartate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, RHEA:14377]
synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" RELATED [EC:4.1.3.14]
synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" RELATED [EC:4.1.3.14]
synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" RELATED [EC:4.1.3.14]
synonym: "erythro-beta-hydroxyaspartate aldolase activity" RELATED [EC:4.1.3.14]
synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" RELATED [EC:4.1.3.14]
xref: EC:4.1.3.14
xref: KEGG_REACTION:R00478
xref: MetaCyc:RXN-11769
xref: RHEA:14377
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047563
name: 3-hydroxybenzoate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O2 = 2,3-dihydroxybenzoate + A + H2O." [EC:1.14.99.23, RHEA:14193]
synonym: "3-HBA-2-hydroxylase activity" RELATED [EC:1.14.99.23]
synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.99.23]
xref: EC:1.14.99.23
xref: KEGG_REACTION:R01508
xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN
xref: RHEA:14193
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047564
name: 3-hydroxycyclohexanone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione." [EC:1.1.99.26, RHEA:15905]
synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.26]
xref: EC:1.1.99.26
xref: KEGG_REACTION:R03212
xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN
xref: RHEA:15905
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047565
name: 3-hydroxypropionate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + H+ + NADH." [EC:1.1.1.59, RHEA:13357]
synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.59]
xref: EC:1.1.1.59
xref: KEGG_REACTION:R01608
xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN
xref: RHEA:13357
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047566
name: 3-ketovalidoxylamine C-N-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H+." [EC:4.3.3.1, RHEA:22768]
synonym: "3-ketovalidoxylamine A C-N-lyase activity" RELATED [EC:4.3.3.1]
synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1]
synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" RELATED [EC:4.3.3.1]
synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" RELATED [EC:4.3.3.1]
xref: EC:4.3.3.1
xref: KEGG_REACTION:R04367
xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN
xref: RHEA:22768
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0047567
name: 3-methyleneoxindole reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + H+ + NADPH." [EC:1.3.1.17, RHEA:20257]
synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.17]
synonym: "3-methyloxindole:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.17]
xref: EC:1.3.1.17
xref: KEGG_REACTION:R03930
xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN
xref: RHEA:20257
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047568
name: 3-oxo-5-beta-steroid 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN]
synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" RELATED [EC:1.3.99.6]
synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" RELATED [EC:1.3.99.6]
synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" RELATED [EC:1.3.99.6]
synonym: "delta4-3-ketosteroid 5-beta-reductase activity" RELATED [EC:1.3.99.6]
xref: EC:1.3.99.6
xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN
xref: RHEA:24172
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047569
name: 3-oxoadipate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN]
synonym: "3-oxoadipate coenzyme A-transferase activity" RELATED [EC:2.8.3.6]
synonym: "3-oxoadipate succinyl-CoA transferase activity" RELATED [EC:2.8.3.6]
synonym: "beta-ketoadipate:succinyl-CoA transferase activity" RELATED [EC:2.8.3.6]
synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" RELATED [EC:2.8.3.6]
xref: EC:2.8.3.6
xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN
xref: RHEA:12048
xref: UM-BBD_reactionID:r1050
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047570
name: 3-oxoadipate enol-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN]
synonym: "3-ketoadipate enol-lactonase activity" RELATED [EC:3.1.1.24]
synonym: "3-oxoadipic enol-lactone hydrolase activity" RELATED [EC:3.1.1.24]
synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" RELATED [EC:3.1.1.24]
synonym: "beta-ketoadipate enol-lactone hydrolase activity" RELATED [EC:3.1.1.24]
synonym: "beta-ketoadipic enol-lactone hydrolase activity" RELATED [EC:3.1.1.24]
synonym: "carboxymethylbutenolide lactonase activity" RELATED [EC:3.1.1.24]
xref: EC:3.1.1.24
xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN
xref: RHEA:10184
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047571
name: 3-oxosteroid 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN]
synonym: "1-ene-dehydrogenase activity" RELATED [EC:1.3.99.4]
synonym: "3-ketosteroid-1-en-dehydrogenase activity" RELATED [EC:1.3.99.4]
synonym: "3-ketosteroid-delta1-dehydrogenase activity" RELATED [EC:1.3.99.4]
synonym: "3-oxosteroid delta1-dehydrogenase activity" RELATED [EC:1.3.99.4]
synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" RELATED [EC:1.3.99.4]
synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" RELATED [EC:1.3.99.4]
synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" RELATED [EC:1.3.99.4]
synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" RELATED [EC:1.3.99.4]
synonym: "delta1-dehydrogenase activity" RELATED [EC:1.3.99.4]
synonym: "delta1-steroid reductase activity" RELATED [EC:1.3.99.4]
xref: EC:1.3.99.4
xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN
xref: RHEA:13329
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047572
name: 3-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + H2O = D-glycerate + phosphate." [EC:3.1.3.38, RHEA:12412]
synonym: "3-PGA phosphatase activity" RELATED [EC:3.1.3.38]
synonym: "D-3-phosphoglycerate phosphatase activity" RELATED [EC:3.1.3.38]
synonym: "D-glycerate-3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.38]
xref: EC:3.1.3.38
xref: KEGG_REACTION:R01511
xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN
xref: RHEA:12412
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047573
name: 4-acetamidobutyrate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63]
synonym: "4-acetamidobutanoate amidohydrolase activity" RELATED [EC:3.5.1.63]
xref: EC:3.5.1.63
xref: MetaCyc:RXN-36
xref: RHEA:15897
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047574
name: 4-acetamidobutyryl-CoA deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate." [EC:3.5.1.51, RHEA:22928]
synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" RELATED [EC:3.5.1.51]
synonym: "aminobutyryl-CoA thiolesterase activity" RELATED [EC:3.5.1.51]
synonym: "deacetylase-thiolesterase activity" RELATED [EC:3.5.1.51]
xref: EC:3.5.1.51
xref: KEGG_REACTION:R04056
xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN
xref: RHEA:22928
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047575
name: 4-carboxymuconolactone decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2." [EC:4.1.1.44, RHEA:23348]
synonym: "4-carboxymonolactone carboxy-lyase activity" RELATED [EC:4.1.1.44]
synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" RELATED [EC:4.1.1.44]
synonym: "4-carboxymuconolactone carboxy-lyase activity" RELATED [EC:4.1.1.44]
synonym: "gamma-4-carboxymuconolactone decarboxylase activity" RELATED [EC:4.1.1.44]
xref: EC:4.1.1.44
xref: KEGG_REACTION:R03470
xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN
xref: RHEA:23348
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047576
name: 4-chlorobenzoate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+." [RHEA:23440]
synonym: "4-chlorobenzoate chlorohydrolase activity" RELATED [EC:3.8.1.6]
synonym: "halobenzoate dehalogenase activity" RELATED [EC:3.8.1.6]
xref: EC:3.8.1.6
xref: KEGG_REACTION:R01307
xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN
xref: RHEA:23440
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0047577
name: 4-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = H+ + NADH + succinate semialdehyde." [EC:1.1.1.61, RHEA:23948]
synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.61]
synonym: "gamma-hydroxybutyrate dehydrogenase activity" RELATED [EC:1.1.1.61]
xref: EC:1.1.1.61
xref: KEGG_REACTION:R01644
xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
xref: RHEA:23948
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047578
name: 4-hydroxyglutamate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN]
synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.23]
synonym: "4-hydroxyglutamate aminotransferase activity" EXACT []
xref: EC:2.6.1.23
xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-6784393 "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)"
xref: RHEA:10480
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047579
name: 4-hydroxymandelate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-4-hydroxymandelate + H+ + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2." [EC:1.1.3.19, RHEA:15833]
synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.19]
synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" RELATED [EC:1.1.3.19]
xref: EC:1.1.3.19
xref: KEGG_REACTION:R02673
xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN
xref: RHEA:15833
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047580
name: 4-hydroxyproline epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, RHEA:21152]
synonym: "4-hydroxyproline 2-epimerase activity" RELATED [EC:5.1.1.8]
synonym: "hydroxyproline 2-epimerase activity" RELATED [EC:5.1.1.8]
synonym: "hydroxyproline epimerase activity" RELATED [EC:5.1.1.8]
synonym: "L-hydroxyproline epimerase activity" RELATED [EC:5.1.1.8]
xref: EC:5.1.1.8
xref: KEGG_REACTION:R03296
xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN
xref: RHEA:21152
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047581
name: 4-methyleneglutamate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH4 = 4-methylene-L-glutamine + AMP + diphosphate + 2 H+." [EC:6.3.1.7, RHEA:13853]
synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" RELATED [EC:6.3.1.7]
synonym: "4-methyleneglutamine synthetase activity" RELATED [EC:6.3.1.7]
xref: EC:6.3.1.7
xref: KEGG_REACTION:R02711
xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN
xref: RHEA:13853
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047582
name: 4-methyleneglutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4." [EC:3.5.1.67, RHEA:14741]
synonym: "4-methylene-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.67]
synonym: "4-methyleneglutamine amidohydrolase activity" RELATED [EC:3.5.1.67]
synonym: "4-methyleneglutamine deamidase activity" RELATED [EC:3.5.1.67]
xref: EC:3.5.1.67
xref: KEGG_REACTION:R02712
xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN
xref: RHEA:14741
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047583
name: 4-methyloxaloacetate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H2O = H+ + methanol + oxaloacetate." [EC:3.1.1.44, RHEA:10564]
synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" RELATED [EC:3.1.1.44]
xref: EC:3.1.1.44
xref: KEGG_REACTION:R01144
xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN
xref: RHEA:10564
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047584
name: 4-oxalmesaconate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.83, RHEA:17401]
synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83]
synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" RELATED [EC:4.2.1.83]
synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" RELATED [EC:4.2.1.83]
synonym: "4-carboxy-2-oxohexenedioate hydratase activity" RELATED [EC:4.2.1.83]
synonym: "gamma-oxalmesaconate hydratase activity" RELATED [EC:4.2.1.83]
synonym: "oxalmesaconate hydratase activity" RELATED [EC:4.2.1.83]
xref: EC:4.2.1.83
xref: KEGG_REACTION:R04478
xref: MetaCyc:RXN-2463
xref: RHEA:17401
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047585
name: 4-pyridoxolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate + H+." [EC:3.1.1.27, RHEA:14301]
synonym: "4-pyridoxolactone lactonohydrolase activity" RELATED [EC:3.1.1.27]
xref: EC:3.1.1.27
xref: KEGG_REACTION:R02992
xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN
xref: RHEA:14301
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047586
name: 5'-acylphosphoadenosine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN]
synonym: "5'-acylphosphoadenosine acylhydrolase activity" RELATED [EC:3.6.1.20]
synonym: "5-phosphoadenosine hydrolase activity" RELATED [EC:3.6.1.20]
xref: EC:3.6.1.20
xref: MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN
xref: RHEA:16837
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0047587
name: 5-alpha-hydroxysteroid dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O." [EC:4.2.1.62, RHEA:22064]
synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" RELATED [EC:4.2.1.62]
synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" RELATED [EC:4.2.1.62]
synonym: "5alpha-hydroxysteroid dehydratase activity" RELATED [EC:4.2.1.62]
xref: EC:4.2.1.62
xref: KEGG_REACTION:R03675
xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN
xref: RHEA:22064
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047588
name: 5-aminopentanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN]
synonym: "5-aminonorvaleramidase activity" RELATED [EC:3.5.1.30]
synonym: "5-aminopentanamide amidohydrolase activity" RELATED [EC:3.5.1.30]
synonym: "5-aminovaleramidase activity" RELATED [EC:3.5.1.30]
xref: EC:3.5.1.30
xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN
xref: RHEA:15677
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047589
name: 5-aminovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, RHEA:10212]
synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.48]
synonym: "5-aminovalerate aminotransferase activity" EXACT []
synonym: "delta-aminovalerate aminotransferase activity" RELATED [EC:2.6.1.48]
synonym: "delta-aminovalerate transaminase activity" RELATED [EC:2.6.1.48]
xref: EC:2.6.1.48
xref: KEGG_REACTION:R02274
xref: MetaCyc:VAGL-RXN
xref: RHEA:10212
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047590
name: 5-dehydro-2-deoxygluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN]
synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" RELATED [EC:2.7.1.92]
synonym: "5-keto-2-deoxygluconokinase activity" RELATED [EC:2.7.1.92]
synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.92]
synonym: "DKH kinase activity" RELATED [EC:2.7.1.92]
xref: EC:2.7.1.92
xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN
xref: RHEA:13497
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047591
name: 5-hydroxypentanoate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate." [EC:2.8.3.14, RHEA:23496]
synonym: "5-hydroxyvalerate CoA-transferase activity" RELATED [EC:2.8.3.14]
synonym: "5-hydroxyvalerate coenzyme A transferase activity" RELATED [EC:2.8.3.14]
synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" RELATED [EC:2.8.3.14]
xref: EC:2.8.3.14
xref: KEGG_REACTION:R04057
xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN
xref: RHEA:23496
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047592
name: 5-pyridoxate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP+." [RHEA:11152]
synonym: "5-pyridoxate oxidase activity" RELATED [EC:1.14.13.241]
xref: EC:1.14.13.241
xref: KEGG_REACTION:R04570
xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN
xref: RHEA:11152
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047593
name: 6-acetylglucose deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate + H+." [EC:3.1.1.33, RHEA:18485]
synonym: "6-acetyl-D-glucose acetylhydrolase activity" RELATED [EC:3.1.1.33]
synonym: "6-O-acetylglucose deacetylase activity" RELATED [EC:3.1.1.33]
xref: EC:3.1.1.33
xref: KEGG_REACTION:R00327
xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN
xref: RHEA:18485
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047594
name: 6-beta-hydroxyhyoscyamine epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H2O + H+ + scopolamine + succinate." [EC:1.14.20.13, RHEA:12797]
synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" RELATED [EC:1.14.20.13]
synonym: "6beta-hydroxyhyoscyamine epoxidase activity" RELATED [EC:1.14.20.13]
synonym: "hydroxyhyoscyamine dioxygenase activity" RELATED [EC:1.14.20.13]
xref: EC:1.14.20.13
xref: KEGG_REACTION:R03737
xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN
xref: RHEA:12797
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0047595
name: 6-hydroxynicotinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN]
synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.1]
synonym: "6-hydroxynicotinic reductase activity" RELATED [EC:1.3.7.1]
synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.1]
synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" RELATED [EC:1.3.7.1]
synonym: "6-oxotetrahydronicotinate dehydrogenase activity" RELATED [EC:1.3.7.1]
synonym: "HNA reductase activity" RELATED [EC:1.3.7.1]
xref: EC:1.3.7.1
xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN
xref: RHEA:17225
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047596
name: 6-methylsalicylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2." [EC:4.1.1.52, RHEA:23112]
synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" RELATED [EC:4.1.1.52]
synonym: "6-methylsalicylate carboxy-lyase activity" RELATED [EC:4.1.1.52]
synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" RELATED [EC:4.1.1.52]
synonym: "6-MSA decarboxylase activity" RELATED [EC:4.1.1.52]
xref: EC:4.1.1.52
xref: KEGG_REACTION:R03567
xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN
xref: RHEA:23112
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047597
name: 6-oxocineole dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxocineole + H+ + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP+." [EC:1.14.13.51, RHEA:24324]
synonym: "6-oxocineole oxygenase activity" RELATED [EC:1.14.13.51]
synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.13.51]
xref: EC:1.14.13.51
xref: KEGG_REACTION:R02995
xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN
xref: RHEA:24324
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047598
name: 7-dehydrocholesterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH." [RHEA:23984]
synonym: "7-DHC reductase activity" RELATED [EC:1.3.1.21]
synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" RELATED [EC:1.3.1.21]
synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21]
synonym: "sterol delta7-reductase activity" RELATED [EC:1.3.1.21]
xref: EC:1.3.1.21
xref: MetaCyc:RXN66-323
xref: Reactome:R-HSA-196402 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol"
xref: Reactome:R-HSA-6807055 "DHCR7 reduces 7-dehydroCHOL to CHOL"
xref: RHEA:23984
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047599
name: 8-oxocoformycin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + 2 H+ + NADPH." [EC:1.1.1.235, RHEA:23168]
synonym: "8-ketodeoxycoformycin reductase activity" RELATED [EC:1.1.1.235]
synonym: "coformycin:NADP+ 8-oxidoreductase activity" RELATED [EC:1.1.1.235]
xref: EC:1.1.1.235
xref: KEGG_REACTION:R03667
xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN
xref: RHEA:23168
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047600
name: abequosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN]
synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" RELATED [EC:2.4.1.60]
synonym: "trihexose diphospholipid abequosyltransferase activity" RELATED [EC:2.4.1.60]
xref: EC:2.4.1.60
xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN
xref: RHEA:34183
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047601
name: acetate kinase (diphosphate) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate." [EC:2.7.2.12, RHEA:24276]
synonym: "acetate kinase (pyrophosphate) activity" RELATED [EC:2.7.2.12]
synonym: "diphosphate:acetate phosphotransferase activity" RELATED [EC:2.7.2.12]
synonym: "pyrophosphate-acetate phosphotransferase activity" RELATED [EC:2.7.2.12]
xref: EC:2.7.2.12
xref: KEGG_REACTION:R00320
xref: MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN
xref: RHEA:24276
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047602
name: acetoacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + H+ = acetone + CO2." [EC:4.1.1.4, RHEA:19729]
synonym: "acetoacetate carboxy-lyase (acetone-forming)" RELATED [EC:4.1.1.4]
synonym: "acetoacetate carboxy-lyase activity" RELATED [EC:4.1.1.4]
synonym: "acetoacetic acid decarboxylase activity" RELATED [EC:4.1.1.4]
xref: EC:4.1.1.4
xref: KEGG_REACTION:R01366
xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN
xref: RHEA:19729
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047603
name: acetoacetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetyl-CoA + H2O = acetoacetate + CoA + H+." [EC:3.1.2.11, RHEA:15673]
synonym: "acetoacetyl CoA deacylase activity" RELATED [EC:3.1.2.11]
synonym: "acetoacetyl coenzyme A deacylase activity" RELATED [EC:3.1.2.11]
synonym: "acetoacetyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.11]
xref: EC:3.1.2.11
xref: KEGG_REACTION:R01358
xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN
xref: RHEA:15673
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0047604
name: acetoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, RHEA:12092]
synonym: "acetylmethylcarbinol racemase activity" RELATED [EC:5.1.2.4]
xref: EC:5.1.2.4
xref: KEGG_REACTION:R02949
xref: MetaCyc:ACETOIN-RACEMASE-RXN
xref: RHEA:12092
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0047605
name: acetolactate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN]
synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5]
synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" RELATED [EC:4.1.1.5]
synonym: "alpha-acetolactate decarboxylase activity" RELATED [EC:4.1.1.5]
xref: EC:4.1.1.5
xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN
xref: RHEA:21580
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047606
name: (S)-hydroxynitrile lyase activity
namespace: molecular_function
alt_id: GO:0046991
def: "Catalysis of the reaction: a (S)-hydroxynitrile = hydrogen cyanide + an aldehyde or ketone." [EC:4.1.2.47, PMID:3377504]
synonym: "alpha-hydroxynitrile lyase activity" NARROW []
synonym: "hydroxynitrilase activity" BROAD []
synonym: "hydroxynitrile lyase activity" EXACT []
synonym: "oxynitrilase activity" RELATED []
xref: EC:4.1.2.47
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047608
name: acetylindoxyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN]
synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" RELATED [EC:1.7.3.2]
xref: EC:1.7.3.2
xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN
xref: RHEA:16941
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047609
name: acetylputrescine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine." [EC:3.5.1.62, RHEA:23412]
synonym: "N-acetylputrescine acetylhydrolase activity" RELATED [EC:3.5.1.62]
xref: EC:3.5.1.62
xref: KEGG_REACTION:R01156
xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN
xref: RHEA:23412
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047610
name: acetylsalicylate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylsalicylate + H2O = acetate + H+ + salicylate." [EC:3.1.1.55, RHEA:11752]
synonym: "acetylsalicylate O-acetylhydrolase activity" RELATED [EC:3.1.1.55]
synonym: "acetylsalicylic acid esterase activity" RELATED [EC:3.1.1.55]
synonym: "aspirin esterase activity" RELATED [EC:3.1.1.55]
synonym: "aspirin hydrolase activity" RELATED [EC:3.1.1.55]
xref: EC:3.1.1.55
xref: KEGG_REACTION:R02942
xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN
xref: RHEA:11752
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047611
name: acetylspermidine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine." [EC:3.5.1.48, RHEA:23928]
synonym: "8-N-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48]
synonym: "N(1)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48]
synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48]
synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48]
synonym: "N1-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48]
synonym: "N8-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48]
synonym: "N8-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
synonym: "N8-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
xref: EC:3.5.1.48
xref: KEGG_REACTION:R07300
xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN
xref: RHEA:23928
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047612
name: acid-CoA ligase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H+ + phosphate." [RHEA:10968]
synonym: "acid:CoA ligase (GDP-forming)" RELATED [EC:6.2.1.10]
synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" RELATED [EC:6.2.1.10]
synonym: "acyl-CoA synthetase (GDP-forming) activity" RELATED [EC:6.2.1.10]
xref: EC:6.2.1.10
xref: KEGG_REACTION:R00394
xref: MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN
xref: RHEA:10968
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047613
name: aconitate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate." [EC:4.1.1.6, RHEA:15253]
synonym: "CAD activity" BROAD [EC:4.1.1.6]
synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" RELATED [EC:4.1.1.6]
synonym: "cis-aconitate carboxy-lyase activity" RELATED [EC:4.1.1.6]
synonym: "cis-aconitic decarboxylase activity" RELATED [EC:4.1.1.6]
xref: EC:4.1.1.6
xref: KEGG_REACTION:R02243
xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN
xref: RHEA:15253
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047614
name: aconitate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [RHEA:17265]
synonym: "aconitate D-isomerase activity" EXACT []
synonym: "aconitate delta2-delta3-isomerase activity" RELATED [EC:5.3.3.7]
synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7]
xref: EC:5.3.3.7
xref: KEGG_REACTION:R02244
xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN
xref: RHEA:17265
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0047615
name: actinomycin lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN]
synonym: "actinomycin lactonohydrolase activity" RELATED [EC:3.1.1.39]
xref: EC:3.1.1.39
xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047616
name: acyl-CoA dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8]
synonym: "2-enoyl-CoA reductase activity" RELATED [EC:1.3.1.8]
synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" RELATED [EC:1.3.1.8]
synonym: "crotonyl coenzyme A reductase activity" RELATED [EC:1.3.1.8]
synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.3.1.8]
synonym: "enoyl coenzyme A reductase activity" RELATED [EC:1.3.1.8]
xref: EC:1.3.1.8
xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN
xref: RHEA:22460
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047617
name: fatty acyl-CoA hydrolase activity
namespace: molecular_function
alt_id: GO:0008778
alt_id: GO:0016291
alt_id: GO:0016292
def: "Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781]
subset: goslim_chembl
synonym: "acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.20]
synonym: "acyl coenzyme A thioesterase activity" RELATED [EC:3.1.2.20]
synonym: "acyl-CoA hydrolase activity" BROAD []
synonym: "acyl-CoA thioesterase activity" EXACT []
synonym: "acyl-CoA thioesterase I activity" NARROW []
synonym: "acyl-CoA thioesterase II activity" NARROW []
synonym: "acyl-CoA thiolesterase activity" EXACT []
synonym: "thioesterase B" RELATED [EC:3.1.2.20]
synonym: "thioesterase II" RELATED [EC:3.1.2.20]
xref: EC:3.1.2.20
xref: MetaCyc:ACYL-COA-HYDROLASE-RXN
xref: Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA"
xref: Reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA"
xref: Reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA"
xref: RHEA:16781
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0047618
name: acylagmatine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-benzoylagmatine + H2O = agmatine + benzoate." [EC:3.5.1.40, RHEA:15065]
synonym: "acylagmatine amidohydrolase activity" RELATED [EC:3.5.1.40]
synonym: "acylagmatine deacylase activity" RELATED [EC:3.5.1.40]
synonym: "benzoylagmatine amidohydrolase activity" RELATED [EC:3.5.1.40]
xref: EC:3.5.1.40
xref: KEGG_REACTION:R01425
xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN
xref: RHEA:15065
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047619
name: acylcarnitine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN]
synonym: "carnitine ester hydrolase activity" RELATED [EC:3.1.1.28]
synonym: "HACH" RELATED [EC:3.1.1.28]
synonym: "high activity acylcarnitine hydrolase activity" RELATED [EC:3.1.1.28]
synonym: "long-chain acyl-L-carnitine hydrolase activity" RELATED [EC:3.1.1.28]
synonym: "O-acylcarnitine acylhydrolase activity" RELATED [EC:3.1.1.28]
synonym: "palmitoyl carnitine hydrolase activity" RELATED [EC:3.1.1.28]
synonym: "palmitoyl-L-carnitine hydrolase activity" RELATED [EC:3.1.1.28]
synonym: "palmitoylcarnitine hydrolase activity" RELATED [EC:3.1.1.28]
xref: EC:3.1.1.28
xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN
xref: RHEA:17101
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047620
name: acylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN]
synonym: "ATP:acylglycerol 3-phosphotransferase activity" RELATED [EC:2.7.1.94]
synonym: "MGK" RELATED [EC:2.7.1.94]
synonym: "monoacylglycerol kinase (phosphorylating)" RELATED [EC:2.7.1.94]
synonym: "monoacylglycerol kinase activity" RELATED [EC:2.7.1.94]
synonym: "monoglyceride kinase activity" RELATED [EC:2.7.1.94]
synonym: "monoglyceride phosphokinase activity" RELATED [EC:2.7.1.94]
synonym: "sn-2-monoacylglycerol kinase activity" RELATED [EC:2.7.1.94]
xref: EC:2.7.1.94
xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN
xref: Reactome:R-HSA-5696074 "AGK:Mg2+ phosphorylates MAG, DAG"
xref: RHEA:19293
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047621
name: acylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [RHEA:19009]
synonym: "3-acylpyruvate acylhydrolase activity" RELATED [EC:3.7.1.5]
xref: EC:3.7.1.5
xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN
xref: RHEA:19009
xref: UM-BBD_reactionID:r1401
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047622
name: adenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN]
synonym: "adenosinase activity" RELATED [EC:3.2.2.7]
synonym: "adenosine hydrolase activity" RELATED [EC:3.2.2.7]
synonym: "adenosine ribohydrolase activity" RELATED [EC:3.2.2.7]
synonym: "ANase activity" RELATED [EC:3.2.2.7]
synonym: "N-ribosyladenine ribohydrolase activity" RELATED [EC:3.2.2.7]
xref: EC:3.2.2.7
xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN
xref: RHEA:18669
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0047623
name: adenosine-phosphate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP." [EC:3.5.4.17]
comment: Consider instead annotating to one of the more specific terms: AMP deaminase activity ; GO:0003876, ADP deaminase activity ; GO:0047629, or ATP deaminase activity ; GO:0047692.
synonym: "adenine nucleotide deaminase activity" RELATED [EC:3.5.4.17]
synonym: "adenosine (phosphate) deaminase activity" RELATED [EC:3.5.4.17]
synonym: "adenosine-phosphate aminohydrolase activity" RELATED [EC:3.5.4.17]
xref: EC:3.5.4.17
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047624
name: adenosine-tetraphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN]
synonym: "adenosine-tetraphosphate phosphohydrolase activity" RELATED [EC:3.6.1.14]
xref: EC:3.6.1.14
xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN
xref: RHEA:24500
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047625
name: S-adenosyl-L-methionine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-5'-thioadenosine." [RHEA:21932]
synonym: "adenosyl methionine cyclotransferase activity" EXACT []
synonym: "adenosylmethionine cyclotransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing) activity" RELATED [EC:4.4.1.42]
synonym: "SAM lyase activity" EXACT []
xref: EC:4.4.1.42
xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN
xref: RHEA:21932
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047626
name: obsolete adenosylmethionine hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + H2O = S-methyl-5'-thioadenosine + L-homoserine + H+." [GOC:curators]
comment: This term has been obsoleted because there is no evidence that this function exists.
synonym: "adenosyl methionine hydrolase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047625

[Term]
id: GO:0047627
name: adenylylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-adenylyl sulfate + H2O = AMP + 2 H+ + sulfate." [EC:3.6.2.1, RHEA:17041]
synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" RELATED [EC:3.6.2.1]
synonym: "adenylylsulfate sulfohydrolase activity" RELATED [EC:3.6.2.1]
synonym: "adenylylsulphatase activity" EXACT []
xref: EC:3.6.2.1
xref: KEGG_REACTION:R00531
xref: MetaCyc:ADENYLYLSULFATASE-RXN
xref: RHEA:17041
is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides

[Term]
id: GO:0047628
name: ADP-thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN]
synonym: "adenosine diphosphate-thymidine phosphotransferase activity" RELATED [EC:2.7.1.118]
synonym: "ADP:dThd phosphotransferase activity" RELATED [EC:2.7.1.118]
synonym: "ADP:thymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.118]
xref: EC:2.7.1.118
xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN
xref: RHEA:13413
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047629
name: ADP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN]
synonym: "adenosine diphosphate deaminase activity" RELATED [EC:3.5.4.7]
synonym: "adenosinepyrophosphate deaminase activity" RELATED [EC:3.5.4.7]
synonym: "ADP aminohydrolase activity" RELATED [EC:3.5.4.7]
xref: EC:3.5.4.7
xref: MetaCyc:ADP-DEAMINASE-RXN
xref: RHEA:12741
is_a: GO:0047623 ! adenosine-phosphate deaminase activity

[Term]
id: GO:0047630
name: ADP-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate." [RHEA:15861]
synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" RELATED [EC:3.1.3.28]
synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" RELATED [EC:3.1.3.28]
synonym: "ADPphosphoglycerate phosphatase activity" RELATED [EC:3.1.3.28]
xref: EC:3.1.3.28
xref: KEGG_REACTION:R03969
xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN
xref: RHEA:15861
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047631
name: ADP-ribose diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13]
synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT []
synonym: "ADP-ribose phosphohydrolase activity" EXACT []
synonym: "ADP-ribose pyrophosphatase activity" EXACT []
synonym: "ADP-ribose ribophosphohydrolase activity" RELATED [EC:3.6.1.13]
synonym: "ADPR-PPase activity" EXACT []
synonym: "ADPribose diphosphatase activity" RELATED [EC:3.6.1.13]
synonym: "ADPribose pyrophosphatase activity" RELATED [EC:3.6.1.13]
xref: EC:3.6.1.13
xref: MetaCyc:RXN0-1441
xref: Reactome:R-HSA-2393939 "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP"
xref: Reactome:R-HSA-2393954 "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP"
xref: Reactome:R-HSA-5696049 "ADPRM hydrolyses ADP-ribose to R5P and AMP"
xref: RHEA:10412
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047632
name: agmatine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]
synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12]
synonym: "agmatine iminohydrolase activity" RELATED [EC:3.5.3.12]
xref: EC:3.5.3.12
xref: MetaCyc:AGMATINE-DEIMINASE-RXN
xref: RHEA:18037
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047633
name: agmatine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H+." [EC:2.7.3.10, RHEA:15953]
synonym: "ATP:agmatine 4-N-phosphotransferase activity" RELATED [EC:2.7.3.10]
synonym: "ATP:agmatine N4-phosphotransferase activity" RELATED [EC:2.7.3.10]
synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10]
xref: EC:2.7.3.10
xref: KEGG_REACTION:R01417
xref: MetaCyc:AGMATINE-KINASE-RXN
xref: RHEA:15953
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047634
name: agmatine N4-coumaroyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H+." [EC:2.3.1.64, RHEA:13405]
synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" RELATED [EC:2.3.1.64]
synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" RELATED [EC:2.3.1.64]
synonym: "agmatine coumaroyltransferase activity" RELATED [EC:2.3.1.64]
synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" RELATED [EC:2.3.1.64]
xref: EC:2.3.1.64
xref: KEGG_REACTION:R01617
xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN
xref: RHEA:13405
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047635
name: alanine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN]
synonym: "alanine--oxo-acid aminotransferase activity" RELATED [EC:2.6.1.12]
synonym: "alanine-keto acid aminotransferase activity" RELATED [EC:2.6.1.12]
synonym: "alanine-oxo acid aminotransferase activity" RELATED [EC:2.6.1.12]
synonym: "alanine-oxo-acid aminotransferase activity" EXACT []
synonym: "L-alanine-alpha-keto acid aminotransferase activity" RELATED [EC:2.6.1.12]
synonym: "L-alanine:2-oxo-acid aminotransferase activity" RELATED [EC:2.6.1.12]
synonym: "leucine-alanine transaminase activity" RELATED [EC:2.6.1.12]
xref: EC:2.6.1.12
xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN
xref: RHEA:19953
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047636
name: alanopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2'-iminodipropanoate + H2O + NAD+ = L-alanine + H+ + NADH + pyruvate." [EC:1.5.1.17, RHEA:17589]
synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" RELATED [EC:1.5.1.17]
synonym: "ADH" RELATED [EC:1.5.1.17]
synonym: "alanopine: NAD oxidoreductase activity" RELATED [EC:1.5.1.17]
synonym: "alanopine:NAD oxidoreductase activity" RELATED [EC:1.5.1.17]
synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" RELATED [EC:1.5.1.17]
synonym: "ALPDH" RELATED [EC:1.5.1.17]
synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.17]
xref: EC:1.5.1.17
xref: KEGG_REACTION:R00398
xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN
xref: RHEA:17589
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047637
name: phosphatidylglycerol alanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)." [EC:2.3.2.11]
synonym: "alanyl phosphatidylglycerol synthetase activity" EXACT [EC:2.3.2.11]
xref: EC:2.3.2.11
xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN
xref: RHEA:20489
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0047638
name: albendazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: albendazole + H+ + NADPH + O2 = albendazole S-oxide + H2O + NADP+." [EC:1.14.13.32, RHEA:10796]
synonym: "albendazole oxidase activity" RELATED [EC:1.14.13.32]
synonym: "albendazole sulfoxidase activity" RELATED [EC:1.14.13.32]
synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" RELATED [EC:1.14.13.32]
xref: EC:1.14.13.32
xref: KEGG_REACTION:R03712
xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN
xref: RHEA:10796
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047639
name: alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN]
synonym: "alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.13]
synonym: "AOX activity" RELATED [EC:1.1.3.13]
synonym: "ethanol oxidase activity" RELATED [EC:1.1.3.13]
xref: EC:1.1.3.13
xref: MetaCyc:ALCOHOL-OXIDASE-RXN
xref: RHEA:19829
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047640
name: aldose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN]
synonym: "aldose dehydrogenase activity" RELATED [EC:1.1.1.121]
synonym: "D-aldose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.121]
synonym: "dehydrogenase, D-aldohexose" RELATED [EC:1.1.1.121]
xref: EC:1.1.1.121
xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN
xref: RHEA:15917
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047641
name: aldose-6-phosphate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucitol 6-phosphate + NADP+ = D-glucose 6-phosphate + H+ + NADPH." [EC:1.1.1.200, RHEA:20037]
synonym: "A6PR" RELATED [EC:1.1.1.200]
synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" RELATED [EC:1.1.1.200]
synonym: "aldose 6-phosphate reductase activity" RELATED [EC:1.1.1.200]
synonym: "aldose-6-P reductase activity" RELATED [EC:1.1.1.200]
synonym: "aldose-6-phosphate reductase activity" RELATED [EC:1.1.1.200]
synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.200]
synonym: "NADP-dependent aldose 6-phosphate reductase activity" RELATED [EC:1.1.1.200]
synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.200]
xref: EC:1.1.1.200
xref: KEGG_REACTION:R00834
xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN
xref: RHEA:20037
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047642
name: aldose beta-D-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN]
synonym: "aldose b-D-fructosyltransferase activity" EXACT []
synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.162]
xref: EC:2.4.1.162
xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0047643
name: alginate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN]
synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" RELATED [EC:2.4.1.33]
synonym: "mannuronosyl transferase activity" RELATED [EC:2.4.1.33]
xref: EC:2.4.1.33
xref: MetaCyc:ALGINATE-SYNTHASE-RXN
xref: RHEA:46876
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047644
name: alizarin 2-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H+ + UDP." [EC:2.4.1.103, RHEA:20677]
synonym: "alizarin 2-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.103]
synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" RELATED [EC:2.4.1.103]
synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" RELATED [EC:2.4.1.103]
xref: EC:2.4.1.103
xref: KEGG_REACTION:R03573
xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:20677
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047645
name: alkan-1-ol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN]
synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" RELATED [EC:1.1.99.20]
synonym: "alkan-1-ol:acceptor oxidoreductase activity" RELATED [EC:1.1.99.20]
synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20]
xref: EC:1.1.99.20
xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:14685
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047646
name: alkanal monooxygenase (FMN-linked) activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN]
synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3]
synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" RELATED [EC:1.14.14.3]
synonym: "bacterial luciferase activity" RELATED [EC:1.14.14.3]
synonym: "vibrio fischeri luciferase activity" RELATED [EC:1.14.14.3]
xref: EC:1.14.14.3
xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN
xref: RHEA:17181
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047647
name: alkylacetylglycerophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = 2-acetyl-1-alkyl-sn-glycerol + phosphate." [RHEA:18221]
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.59]
synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" RELATED [EC:3.1.3.59]
synonym: "alkylacetylglycerophosphate phosphatase activity" RELATED [EC:3.1.3.59]
xref: EC:3.1.3.59
xref: KEGG_REACTION:R03454
xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN
xref: RHEA:18221
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047648
name: alkylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylammonium." [EC:3.5.1.39, RHEA:20081]
synonym: "N-methylhexanamide amidohydrolase activity" RELATED [EC:3.5.1.39]
xref: EC:3.5.1.39
xref: KEGG_REACTION:R03620
xref: MetaCyc:ALKYLAMIDASE-RXN
xref: RHEA:20081
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047649
name: alkylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H+." [EC:2.7.1.93, RHEA:16937]
synonym: "1-alkylglycerol kinase (phosphorylating)" RELATED [EC:2.7.1.93]
synonym: "alkylglycerol phosphotransferase activity" RELATED [EC:2.7.1.93]
synonym: "ATP-alkylglycerol phosphotransferase activity" RELATED [EC:2.7.1.93]
synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" RELATED [EC:2.7.1.93]
synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" RELATED [EC:2.7.1.93]
xref: EC:2.7.1.93
xref: KEGG_REACTION:R04126
xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN
xref: RHEA:16937
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047650
name: alkylglycerone kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H+." [EC:2.7.1.84, RHEA:23088]
synonym: "alkyldihydroxyacetone kinase (phosphorylating)" RELATED [EC:2.7.1.84]
synonym: "alkyldihydroxyacetone kinase activity" RELATED [EC:2.7.1.84]
synonym: "ATP:O-alkylglycerone phosphotransferase activity" RELATED [EC:2.7.1.84]
xref: EC:2.7.1.84
xref: KEGG_REACTION:R03944
xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN
xref: RHEA:23088
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047651
name: alkylhalidase activity
namespace: molecular_function
def: "Catalysis of the reaction: bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H+." [RHEA:13765]
synonym: "alkyl-halide halidohydrolase activity" RELATED []
synonym: "haloalkane halidohydrolase activity" RELATED []
synonym: "halogenase activity" RELATED []
xref: KEGG_REACTION:R03523
xref: RHEA:13765
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0047652
name: allantoate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN]
synonym: "allantoate amidinohydrolase (decarboxylating)" RELATED [EC:3.5.3.9]
synonym: "allantoate amidohydrolase activity" RELATED [EC:3.5.3.9]
xref: EC:3.5.3.9
xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN
xref: RHEA:27485
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047653
name: allantoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin." [EC:5.1.99.3, RHEA:10804]
xref: EC:5.1.99.3
xref: KEGG_REACTION:R03925
xref: MetaCyc:ALLANTOIN-RACEMASE-RXN
xref: RHEA:10804
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0047654
name: alliin lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN]
synonym: "alkylcysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4]
synonym: "alliin alkyl-sulfenate-lyase activity" RELATED [EC:4.4.1.4]
synonym: "alliinase activity" RELATED [EC:4.4.1.4]
synonym: "cysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4]
synonym: "cysteine sulphoxide lyase activity" RELATED [EC:4.4.1.4]
synonym: "L-cysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4]
synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" RELATED [EC:4.4.1.4]
synonym: "S-alkylcysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4]
xref: EC:4.4.1.4
xref: MetaCyc:ALLIIN-LYASE-RXN
xref: RHEA:20141
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047655
name: allyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + H+ + NADPH." [EC:1.1.1.54, RHEA:12168]
synonym: "allyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.54]
xref: EC:1.1.1.54
xref: KEGG_REACTION:R03572
xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN
xref: RHEA:12168
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047656
name: alpha,alpha-trehalose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN]
synonym: "a,a-trehalose phosphorylase activity" EXACT []
synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.64]
synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64]
xref: EC:2.4.1.64
xref: MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN
xref: RHEA:23512
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0047657
name: alpha-1,3-glucan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN]
synonym: "1,3-alpha-D-glucan synthase activity" RELATED [EC:2.4.1.183]
synonym: "1,3-alpha-glucan synthase activity" EXACT []
synonym: "a-1,3-glucan synthase activity" EXACT []
synonym: "UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.183]
synonym: "UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.183]
synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" RELATED [EC:2.4.1.183]
xref: EC:2.4.1.183
xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN
xref: RHEA:19749
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047658
name: alpha-amino-acid esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN]
synonym: "a-amino-acid esterase activity" EXACT []
synonym: "alpha-amino acid ester hydrolase activity" RELATED [EC:3.1.1.43]
synonym: "alpha-amino-acid ester hydrolase activity" RELATED [EC:3.1.1.43]
synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" RELATED [EC:3.1.1.43]
xref: EC:3.1.1.43
xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN
xref: Reactome:R-HSA-6784959 "BPHL hydrolyses VACV to ACV"
xref: RHEA:17241
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047659
name: alpha-santonin 1,2-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN]
synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" RELATED [EC:1.3.1.47]
synonym: "a-santonin 1,2-reductase activity" EXACT []
xref: EC:1.3.1.47
xref: MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047660
name: amidinoaspartase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea." [EC:3.5.3.14, RHEA:14849]
synonym: "amidinoaspartic amidinohydrolase activity" RELATED [EC:3.5.3.14]
synonym: "N-amidino-L-aspartate amidinohydrolase activity" RELATED [EC:3.5.3.14]
xref: EC:3.5.3.14
xref: KEGG_REACTION:R00777
xref: MetaCyc:AMIDINOASPARTASE-RXN
xref: RHEA:14849
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047661
name: amino-acid racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN]
synonym: "L-amino acid racemase activity" RELATED [EC:5.1.1.10]
xref: EC:5.1.1.10
xref: MetaCyc:AMINO-ACID-RACEMASE-RXN
xref: RHEA:18317
is_a: GO:0036361 ! racemase activity, acting on amino acids and derivatives

[Term]
id: GO:0047662
name: aminobenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN]
synonym: "aminobenzoate carboxy-lyase (aniline-forming)" RELATED [EC:4.1.1.24]
synonym: "aminobenzoate carboxy-lyase activity" RELATED [EC:4.1.1.24]
xref: EC:4.1.1.24
xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN
xref: RHEA:24200
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047663
name: aminoglycoside 6'-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.82, RHEA:16449]
synonym: "6'-aminoglycoside-N-acetyltransferase activity" RELATED [EC:2.3.1.82]
synonym: "AAC(6') activity" RELATED [EC:2.3.1.82]
synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82]
synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT []
synonym: "aminoglycoside-6'-acetyltransferase activity" RELATED [EC:2.3.1.82]
synonym: "aminoglycoside-6-N-acetyltransferase activity" RELATED [EC:2.3.1.82]
synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW []
xref: EC:2.3.1.82
xref: KEGG_REACTION:R01889
xref: MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN
xref: RHEA:16449
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0047664
name: aminoimidazolase activity
namespace: molecular_function
def: "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH3." [RHEA:22348]
synonym: "4-aminoimidazole aminohydrolase activity" RELATED [EC:3.5.4.8]
synonym: "4-aminoimidazole hydrolase activity" RELATED [EC:3.5.4.8]
xref: EC:3.5.4.8
xref: MetaCyc:R13-RXN
xref: RHEA:22348
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0047665
name: aminolevulinate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, RHEA:12480]
synonym: "4,5-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "4,5-dioxovaleric acid aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "4,5-dioxovaleric acid transaminase activity" RELATED [EC:2.6.1.43]
synonym: "4,5-dioxovaleric transaminase activity" RELATED [EC:2.6.1.43]
synonym: "5-aminolevulinate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "5-aminolevulinic acid transaminase activity" RELATED [EC:2.6.1.43]
synonym: "alanine-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "alanine:4,5-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "aminolevulinate aminotransferase activity" EXACT []
synonym: "aminolevulinic acid transaminase activity" RELATED [EC:2.6.1.43]
synonym: "dioxovalerate transaminase activity" RELATED [EC:2.6.1.43]
synonym: "DOVA transaminase activity" RELATED [EC:2.6.1.43]
synonym: "gamma,delta-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "gamma,delta-dioxovaleric acid transaminase activity" RELATED [EC:2.6.1.43]
synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43]
synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" RELATED [EC:2.6.1.43]
synonym: "L-alanine:dioxovalerate transaminase activity" RELATED [EC:2.6.1.43]
xref: EC:2.6.1.43
xref: KEGG_REACTION:R02271
xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN
xref: RHEA:12480
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047666
name: ammonia kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NH4 = ADP + 3 H+ + phosphoramidate." [EC:2.7.3.8, RHEA:11024]
synonym: "ATP:ammonia phosphotransferase activity" RELATED [EC:2.7.3.8]
synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" RELATED [EC:2.7.3.8]
synonym: "phosphoramidate-ADP-phosphotransferase activity" RELATED [EC:2.7.3.8]
xref: EC:2.7.3.8
xref: KEGG_REACTION:R00141
xref: MetaCyc:AMMONIA-KINASE-RXN
xref: RHEA:11024
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047667
name: AMP-thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN]
synonym: "adenylate-nucleoside phosphotransferase activity" RELATED [EC:2.7.1.114]
synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.114]
synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.114]
synonym: "AMP:deoxythymidine kinase activity" RELATED [EC:2.7.1.114]
synonym: "AMP:dThd kinase activity" RELATED [EC:2.7.1.114]
synonym: "AMP:thymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.114]
synonym: "thymidine phosphotransferase activity" RELATED [EC:2.7.1.114]
xref: EC:2.7.1.114
xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN
xref: RHEA:14913
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047668
name: amygdalin beta-glucosidase activity
namespace: molecular_function
alt_id: GO:0080080
def: "Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose." [EC:3.2.1.117, RHEA:14177]
synonym: "(R)-amygdalin beta-glucosidase activity" EXACT []
synonym: "amygdalin b-glucosidase activity" EXACT []
synonym: "amygdalin beta-D-glucohydrolase activity" RELATED [EC:3.2.1.117]
synonym: "amygdalin glucosidase activity" RELATED [EC:3.2.1.117]
synonym: "amygdalin hydrolase activity" RELATED [EC:3.2.1.117]
synonym: "amygdalinase" BROAD [EC:3.2.1.117]
xref: EC:3.2.1.117
xref: KEGG_REACTION:R02985
xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:14177
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0047669
name: amylosucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN]
synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" RELATED [EC:2.4.1.4]
synonym: "sucrose-glucan glucosyltransferase activity" RELATED [EC:2.4.1.4]
synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.4]
xref: EC:2.4.1.4
xref: MetaCyc:AMYLOSUCRASE-RXN
xref: RHEA:24572
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047670
name: anhydrotetracycline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: anhydrotetracycline + H+ + NADPH + O2 = 12-dehydrotetracycline + H2O + NADP+." [EC:1.14.13.38, RHEA:11976]
synonym: "anhydrotetracycline oxygenase activity" RELATED [EC:1.14.13.38]
synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.38]
synonym: "ATC oxygenase activity" RELATED [EC:1.14.13.38]
xref: EC:1.14.13.38
xref: KEGG_REACTION:R04060
xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN
xref: RHEA:11976
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047671
name: cyclopeptine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H+ + S-adenosyl-L-homocysteine." [EC:6.3.2.40, PMID:2995633, RHEA:35091]
synonym: "anthranilate adenylyltransferase activity" RELATED []
synonym: "ATP:anthranilate adenylyltransferase activity" EXACT []
xref: EC:6.3.2.40
xref: KEGG_REACTION:R00979
xref: MetaCyc:RXN-13989
xref: RHEA:35091
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047672
name: anthranilate N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA." [EC:2.3.1.144, RHEA:21600]
synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144]
xref: EC:2.3.1.144
xref: KEGG_REACTION:R02453
xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN
xref: RHEA:21600
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047673
name: anthranilate N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA." [EC:2.3.1.113, RHEA:17557]
synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" RELATED [EC:2.3.1.113]
xref: EC:2.3.1.113
xref: KEGG_REACTION:R00989
xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN
xref: RHEA:17557
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047674
name: apiose 1-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + H+ + NADH." [EC:1.1.1.114, RHEA:15301]
synonym: "D-apiitol reductase activity" RELATED [EC:1.1.1.114]
synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.114]
synonym: "D-apiose reductase activity" RELATED [EC:1.1.1.114]
xref: EC:1.1.1.114
xref: KEGG_REACTION:R03577
xref: MetaCyc:APIOSE-1-REDUCTASE-RXN
xref: RHEA:15301
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047675
name: arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O." [EC:4.2.1.5, RHEA:21836]
synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" RELATED [EC:4.2.1.5]
synonym: "D-arabinonate hydro-lyase activity" RELATED [EC:4.2.1.5]
xref: EC:4.2.1.5
xref: KEGG_REACTION:R03032
xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN
xref: RHEA:21836
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047676
name: arachidonate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+." [RHEA:19713]
synonym: "arachidonate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.15]
synonym: "arachidonoyl-CoA synthetase activity" RELATED [EC:6.2.1.15]
xref: EC:6.2.1.15
xref: KEGG_REACTION:R01598
xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN
xref: RHEA:19713
is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity

[Term]
id: GO:0047677
name: arachidonate 8(R)-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, RHEA:14985]
comment: This activity produces the R-enantiomer of HPETE, 8(R)-HPETE. For the reaction producing the S-enantiomer, see GO:0036403.
synonym: "8(R)-lipoxygenase activity" RELATED [EC:1.13.11.40]
synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40]
synonym: "arachidonate 8-lipoxygenase activity" BROAD [GOC:lb]
synonym: "arachidonate:oxygen 8-oxidoreductase activity" RELATED [EC:1.13.11.40]
xref: EC:1.13.11.40
xref: KEGG_REACTION:R01594
xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN
xref: RHEA:14985
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047678
name: arginine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O." [EC:1.13.12.1, RHEA:10548]
synonym: "arginine decarboxy-oxidase activity" RELATED [EC:1.13.12.1]
synonym: "arginine monooxygenase activity" RELATED [EC:1.13.12.1]
synonym: "arginine oxygenase (decarboxylating) activity" RELATED [EC:1.13.12.1]
synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.1]
xref: EC:1.13.12.1
xref: KEGG_REACTION:R00559
xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN
xref: RHEA:10548
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0047679
name: arginine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN]
xref: EC:5.1.1.9
xref: MetaCyc:ARGININE-RACEMASE-RXN
xref: RHEA:18069
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047680
name: aryl-acylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: anilide + H2O = a carboxylate + aniline + H+." [EC:3.5.1.13, RHEA:20297]
synonym: "AAA-1" RELATED [EC:3.5.1.13]
synonym: "AAA-2" RELATED [EC:3.5.1.13]
synonym: "aryl-acylamide amidohydrolase activity" RELATED [EC:3.5.1.13]
synonym: "brain acetylcholinesterase (is associated with AAA-2)" RELATED [EC:3.5.1.13]
synonym: "pseudocholinesterase (associated with arylacylamidase)" RELATED [EC:3.5.1.13]
xref: EC:3.5.1.13
xref: KEGG_REACTION:R01862
xref: MetaCyc:ARYL-ACYLAMIDASE-RXN
xref: RHEA:20297
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047681
name: aryl-alcohol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN]
synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.91]
synonym: "aryl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.91]
synonym: "NADPH-linked benzaldehyde reductase activity" RELATED [EC:1.1.1.91]
xref: EC:1.1.1.91
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN
xref: RHEA:17761
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047682
name: aryl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN]
synonym: "arom. alcohol oxidase activity" RELATED [EC:1.1.3.7]
synonym: "aryl alcohol oxidase activity" RELATED [EC:1.1.3.7]
synonym: "aryl-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.7]
synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7]
xref: EC:1.1.3.7
xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN
xref: RHEA:17541
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047683
name: aryl-aldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [RHEA:19229]
synonym: "aromatic acid reductase activity" RELATED [EC:1.2.1.30]
synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" RELATED [EC:1.2.1.30]
xref: EC:1.2.1.30
xref: MetaCyc:1.2.1.30-RXN
xref: RHEA:19229
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity

[Term]
id: GO:0047684
name: arylamine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP glucose-arylamine glucosyltransferase activity" RELATED [EC:2.4.1.71]
synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" RELATED [EC:2.4.1.71]
synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" RELATED [EC:2.4.1.71]
synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" RELATED [EC:2.4.1.71]
xref: EC:2.4.1.71
xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047685
name: amine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" RELATED [EC:2.8.2.3]
synonym: "amine N-sulfotransferase activity" RELATED [EC:2.8.2.3]
synonym: "amine sulphotransferase activity" EXACT []
synonym: "arylamine sulfotransferase activity" EXACT []
xref: EC:2.8.2.3
xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN
xref: RHEA:24136
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047686
name: arylsulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN]
synonym: "arylsulfate-phenol sulfotransferase activity" RELATED [EC:2.8.2.22]
synonym: "arylsulfate:phenol sulfotransferase activity" RELATED [EC:2.8.2.22]
synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22]
synonym: "arylsulphate sulphotransferase activity" EXACT []
synonym: "ASST" RELATED [EC:2.8.2.22]
xref: EC:2.8.2.22
xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN
xref: RHEA:51072
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047687
name: obsolete ascorbate 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-ascorbate + H2O + O2 = L-threonate + 2 H+ + oxalate." [EC:1.13.11.13]
comment: This term was made obsolete because EC:1.13.11.13 was deleted; the activity is the sum of several enzymatic and spontaneous reactions.
synonym: "AAoxygenase activity" EXACT []
synonym: "ascorbate 2,3-dioxygenase activity" EXACT []
synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT []
is_obsolete: true

[Term]
id: GO:0047688
name: aspartate 4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN]
synonym: "aminomalonic decarboxylase activity" RELATED [EC:4.1.1.12]
synonym: "aspartate beta-decarboxylase activity" RELATED [EC:4.1.1.12]
synonym: "aspartate omega-decarboxylase activity" RELATED [EC:4.1.1.12]
synonym: "aspartic beta-decarboxylase activity" RELATED [EC:4.1.1.12]
synonym: "aspartic omega-decarboxylase activity" RELATED [EC:4.1.1.12]
synonym: "cysteine sulfinic desulfinase activity" RELATED [EC:4.1.1.12]
synonym: "desulfinase activity" RELATED [EC:4.1.1.12]
synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" RELATED [EC:4.1.1.12]
synonym: "L-aspartate 4-carboxy-lyase activity" RELATED [EC:4.1.1.12]
synonym: "L-aspartate beta-decarboxylase activity" RELATED [EC:4.1.1.12]
synonym: "L-cysteine sulfinate acid desulfinase activity" RELATED [EC:4.1.1.12]
xref: EC:4.1.1.12
xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN
xref: RHEA:12621
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047689
name: aspartate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, RHEA:14973]
synonym: "D-aspartate racemase activity" RELATED [EC:5.1.1.13]
xref: EC:5.1.1.13
xref: KEGG_REACTION:R00491
xref: MetaCyc:ASPARTATE-RACEMASE-RXN
xref: RHEA:14973
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047690
name: obsolete aspartyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-asparagine + H+ + hydroxylamine = beta-L-aspartylhydroxamate + NH4." [GOC:curators]
comment: This term was obsoleted because there is no enzyme known to catalyze this reaction.
synonym: "aspartotransferase activity" RELATED [EC:2.3.2.7]
synonym: "beta-aspartyl transferase activity" RELATED [EC:2.3.2.7]
synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" RELATED [EC:2.3.2.7]
is_obsolete: true

[Term]
id: GO:0047691
name: aspulvinone dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate." [EC:2.5.1.35, RHEA:13809]
synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" RELATED [EC:2.5.1.35]
synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" RELATED [EC:2.5.1.35]
xref: EC:2.5.1.35
xref: KEGG_REACTION:R03799
xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN
xref: RHEA:13809
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047692
name: ATP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN]
synonym: "adenosine triphosphate deaminase activity" RELATED [EC:3.5.4.18]
synonym: "ATP aminohydrolase activity" RELATED [EC:3.5.4.18]
xref: EC:3.5.4.18
xref: MetaCyc:ATP-DEAMINASE-RXN
xref: RHEA:13037
is_a: GO:0047623 ! adenosine-phosphate deaminase activity

[Term]
id: GO:0047693
name: ATP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate." [RHEA:14245]
synonym: "adenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.8]
synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8]
synonym: "ATP diphosphohydrolase (diphosphate-forming)" EXACT [EC:3.6.1.8]
synonym: "ATP pyrophosphatase activity" EXACT []
xref: EC:3.6.1.8
xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN
xref: RHEA:14245
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0047694
name: barbiturase activity
namespace: molecular_function
def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN]
synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" RELATED [EC:3.5.2.1]
xref: EC:3.5.2.1
xref: MetaCyc:BARBITURASE-RXN
xref: RHEA:18653
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047695
name: benzoin aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, RHEA:21460]
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" RELATED [EC:4.1.2.38]
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" RELATED [EC:4.1.2.38]
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" RELATED [EC:4.1.2.38]
synonym: "benzaldehyde lyase activity" RELATED [EC:4.1.2.38]
synonym: "diphenylethanone benzaldehyde-lyase activity" RELATED [EC:4.1.2.38]
xref: EC:4.1.2.38
xref: KEGG_REACTION:R00027
xref: MetaCyc:BENZOIN-ALDOLASE-RXN
xref: RHEA:21460
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047696
name: beta-adrenergic receptor kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: [beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H+." [RHEA:19429]
synonym: "[b-adrenergic-receptor] kinase activity" RELATED [EC:2.7.11.15]
synonym: "ADRBK1" RELATED [EC:2.7.11.15]
synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15]
synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15]
synonym: "BARK1" RELATED [EC:2.7.11.15]
synonym: "beta-adrenergic receptor-specific kinase activity" RELATED [EC:2.7.11.15]
synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" RELATED [EC:2.7.11.15]
synonym: "beta-adrenergic-receptor kinase activity" RELATED [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase activity" RELATED [EC:2.7.11.15]
synonym: "beta-AR kinase activity" RELATED [EC:2.7.11.15]
synonym: "beta-ARK" RELATED [EC:2.7.11.15]
synonym: "beta-ARK 1" RELATED [EC:2.7.11.15]
synonym: "beta-ARK 2" RELATED [EC:2.7.11.15]
synonym: "beta-receptor kinase activity" RELATED [EC:2.7.11.15]
synonym: "beta2ARK" RELATED [EC:2.7.11.15]
synonym: "betaARK1" RELATED [EC:2.7.11.15]
synonym: "GRK2" RELATED [EC:2.7.11.15]
synonym: "GRK3" RELATED [EC:2.7.11.15]
synonym: "STK15" RELATED [EC:2.7.11.15]
xref: EC:2.7.11.15
xref: MetaCyc:2.7.11.15-RXN
xref: Reactome:R-HSA-8851797 "ADRB2 in ADRB2:GRK complex is phosphorylated"
xref: Reactome:R-HSA-8866268 "ADBRK1,2 phosphorylate AVPR2"
xref: RHEA:19429
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047697
name: beta-alanopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-beta-alanopine + H2O + NAD+ = beta-alanine + H+ + NADH + pyruvate." [EC:1.5.1.26, RHEA:21684]
synonym: "b-alanopine dehydrogenase activity" EXACT []
synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" RELATED [EC:1.5.1.26]
xref: EC:1.5.1.26
xref: KEGG_REACTION:R00906
xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN
xref: RHEA:21684
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047698
name: beta-alanyl-CoA ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN]
synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT []
synonym: "beta-alanyl coenzyme A ammonia-lyase activity" RELATED [EC:4.3.1.6]
synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" RELATED [EC:4.3.1.6]
xref: EC:4.3.1.6
xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN
xref: RHEA:12416
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047699
name: beta-diketone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + nonane-4,6-dione = butanoate + H+ + pentan-2-one." [RHEA:11908]
synonym: "b-diketone hydrolase activity" EXACT []
synonym: "nonane-4,6-dione acylhydrolase activity" RELATED [EC:3.7.1.7]
synonym: "oxidized PVA hydrolase activity" RELATED [EC:3.7.1.7]
xref: EC:3.7.1.7
xref: KEGG_REACTION:R03781
xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN
xref: RHEA:11908
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047700
name: beta-glucoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN]
synonym: "ATP:cellobiose 6-phosphotransferase activity" RELATED [EC:2.7.1.85]
synonym: "b-glucoside kinase activity" EXACT []
synonym: "beta-D-glucoside kinase (phosphorylating)" RELATED [EC:2.7.1.85]
xref: EC:2.7.1.85
xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN
xref: RHEA:21944
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047701
name: beta-L-arabinosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88]
synonym: "b-L-arabinosidase activity" EXACT []
synonym: "beta-L-arabinoside arabinohydrolase activity" RELATED [EC:3.2.1.88]
synonym: "vicianosidase activity" RELATED [EC:3.2.1.88]
xref: EC:3.2.1.88
xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047702
name: obsolete beta-lysine 5,6-aminomutase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [GOC:curators]
comment: This term was obsoleted because the EC number to which it was associated was transferred to EC:5.4.3.3; which corresponds to D-lysine 5,6-aminomutase activity ; GO:0047826.
synonym: "b-lysine 5,6-aminomutase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047826

[Term]
id: GO:0047703
name: beta-nitroacrylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + H+ + NADPH." [EC:1.3.1.16, RHEA:23892]
synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.16]
synonym: "b-nitroacrylate reductase activity" EXACT []
xref: EC:1.3.1.16
xref: KEGG_REACTION:R03900
xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN
xref: RHEA:23892
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047704
name: bile-salt sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" RELATED [EC:2.8.2.14]
synonym: "BAST I activity" NARROW [EC:2.8.2.14]
synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14]
synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" RELATED [EC:2.8.2.14]
synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" RELATED [EC:2.8.2.14]
synonym: "bile-salt sulphotransferase activity" EXACT []
synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14]
xref: EC:2.8.2.14
xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN
xref: RHEA:14013
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047705
name: bilirubin oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O." [EC:1.3.3.5, RHEA:20980]
synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5]
synonym: "bilirubin:oxygen oxidoreductase activity" RELATED [EC:1.3.3.5]
xref: EC:1.3.3.5
xref: KEGG_REACTION:R02394
xref: MetaCyc:BILIRUBIN-OXIDASE-RXN
xref: RHEA:20980
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0047706
name: biochanin-A reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + H+ + NADPH." [EC:1.3.1.46, RHEA:12817]
synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.46]
xref: EC:1.3.1.46
xref: KEGG_REACTION:R02954
xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN
xref: RHEA:12817
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047707
name: biotin-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN]
synonym: "biotin CoA synthetase activity" RELATED [EC:6.2.1.11]
synonym: "biotin:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.11]
synonym: "biotinyl coenzyme A synthetase activity" RELATED [EC:6.2.1.11]
synonym: "biotinyl-CoA synthetase activity" RELATED [EC:6.2.1.11]
xref: EC:6.2.1.11
xref: MetaCyc:BIOTIN--COA-LIGASE-RXN
xref: RHEA:19681
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047708
name: biotinidase activity
namespace: molecular_function
def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN]
synonym: "amidohydrolase biotinidase activity" RELATED [EC:3.5.1.12]
synonym: "biotin-amide amidohydrolase activity" RELATED [EC:3.5.1.12]
xref: EC:3.5.1.12
xref: MetaCyc:BIOTINIDASE-RXN
xref: Reactome:R-HSA-3076905 "Extracellular BTD hydrolyses BCTN"
xref: Reactome:R-HSA-3325540 "Defective extracellular BTD does not hydrolyse BCTN"
xref: Reactome:R-HSA-4167509 "Mitochondrial BTD hydrolyses BCTN"
xref: Reactome:R-HSA-4225086 "Defective mitochondrial BTD does not hydrolyse BCTN"
xref: RHEA:13081
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047709
name: bis(2-ethylhexyl)phthalate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H+." [EC:3.1.1.60, RHEA:15529]
synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" RELATED [EC:3.1.1.60]
synonym: "DEHP esterase activity" RELATED [EC:3.1.1.60]
xref: EC:3.1.1.60
xref: KEGG_REACTION:R04202
xref: MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN
xref: RHEA:15529
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047710
name: bis(5'-adenosyl)-triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+." [EC:3.6.1.29, RHEA:13893]
synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" RELATED [EC:3.6.1.29]
synonym: "AP(3)A hydrolase activity" RELATED [EC:3.6.1.29]
synonym: "AP(3)Aase activity" RELATED [EC:3.6.1.29]
synonym: "AP3A hydrolase activity" RELATED [EC:3.6.1.29]
synonym: "AP3Aase activity" RELATED [EC:3.6.1.29]
synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" RELATED [EC:3.6.1.29]
synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" RELATED [EC:3.6.1.29]
synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" RELATED [EC:3.6.1.29]
synonym: "dinucleosidetriphosphatase activity" RELATED [EC:3.6.1.29]
synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" RELATED [EC:3.6.1.29]
xref: EC:3.6.1.29
xref: KEGG_REACTION:R00187
xref: MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN
xref: RHEA:13893
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047711
name: blasticidin-S deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN]
synonym: "blasticidin-S aminohydrolase activity" RELATED [EC:3.5.4.23]
xref: EC:3.5.4.23
xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN
xref: RHEA:10148
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047712
name: Cypridina-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "Cypridina luciferase activity" RELATED [EC:1.13.12.6]
synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.6]
synonym: "Cypridina-type luciferase activity" RELATED [EC:1.13.12.6]
synonym: "luciferase (Cypridina luciferin)" RELATED [EC:1.13.12.6]
synonym: "luciferase activity" BROAD [EC:1.13.12.6]
xref: EC:1.13.12.6
xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: RHEA:22760
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047713
name: galactitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactitol + NAD+ = D-tagatose + H+ + NADH." [RHEA:20685]
xref: EC:1.1.1.16
xref: KEGG_REACTION:R02928
xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN
xref: RHEA:20685
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0047714
name: galactolipase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H+." [RHEA:13189]
synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" RELATED [EC:3.1.1.26]
synonym: "galactolipid acylhydrolase activity" RELATED [EC:3.1.1.26]
synonym: "galactolipid lipase activity" RELATED [EC:3.1.1.26]
synonym: "polygalactolipase activity" RELATED [EC:3.1.1.26]
xref: EC:3.1.1.26
xref: MetaCyc:GALACTOLIPASE-RXN
xref: RHEA:13189
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0047715
name: hypotaurocyamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H+." [EC:2.7.3.6, RHEA:24008]
synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" RELATED [EC:2.7.3.6]
xref: EC:2.7.3.6
xref: KEGG_REACTION:R03939
xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN
xref: RHEA:24008
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047716
name: imidazole N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA." [EC:2.3.1.2, RHEA:15813]
synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" RELATED [EC:2.3.1.2]
synonym: "imidazole acetylase activity" RELATED [EC:2.3.1.2]
synonym: "imidazole acetyltransferase activity" RELATED [EC:2.3.1.2]
xref: EC:2.3.1.2
xref: KEGG_REACTION:R03621
xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:15813
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047717
name: imidazoleacetate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + imidazol-4-ylacetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD+." [EC:1.14.13.5, RHEA:19425]
synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.13.5]
synonym: "imidazoleacetate hydroxylase activity" RELATED [EC:1.14.13.5]
synonym: "imidazoleacetic hydroxylase activity" EXACT []
synonym: "imidazoleacetic monooxygenase activity" RELATED [EC:1.14.13.5]
xref: EC:1.14.13.5
xref: KEGG_REACTION:R04066
xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN
xref: RHEA:19425
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047718
name: indanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN]
synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" RELATED [EC:1.1.1.112]
xref: EC:1.1.1.112
xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047719
name: indole 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole + O2 = 2-formamidobenzaldehyde." [EC:1.13.11.17, RHEA:11212]
synonym: "IDO" RELATED [EC:1.13.11.17]
synonym: "indole oxidase activity" RELATED [EC:1.13.11.17]
synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.17]
synonym: "indole:O2 oxidoreductase activity" RELATED [EC:1.13.11.17]
synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.17]
xref: EC:1.13.11.17
xref: KEGG_REACTION:R02338
xref: MetaCyc:INDOLE-23-DIOXYGENASE-RXN
xref: RHEA:11212
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047720
name: indoleacetaldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O." [RHEA:23156]
synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.8.1.3]
synonym: "3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.8.1.3]
synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.8.1.3]
synonym: "indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.8.1.3]
synonym: "indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.8.1.3]
xref: EC:4.8.1.3
xref: KEGG_REACTION:R04093
xref: MetaCyc:RXN-19838
xref: RHEA:23156
is_a: GO:0141122 ! nitrogen-oxygen hydrolyase activity

[Term]
id: GO:0047721
name: indoleacetate-lysine synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H+ + phosphate." [EC:6.3.2.20, RHEA:14857]
synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" RELATED [EC:6.3.2.20]
synonym: "IAA-lysine synthetase activity" RELATED [EC:6.3.2.20]
synonym: "indoleacetate-lysine ligase activity" EXACT []
synonym: "indoleacetate:L-lysine ligase (ADP-forming)" RELATED [EC:6.3.2.20]
synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" RELATED [EC:6.3.2.20]
xref: EC:6.3.2.20
xref: KEGG_REACTION:R03095
xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN
xref: RHEA:14857
is_a: GO:0010279 ! indole-3-acetic acid amido synthetase activity

[Term]
id: GO:0047722
name: indolelactate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD+ = 3-(indol-3-yl)pyruvate + H+ + NADH." [RHEA:20133]
synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.110]
synonym: "indole-3-lactate dehydrogenase activity" EXACT []
synonym: "indolelactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.110]
xref: KEGG_REACTION:R01971
xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN
xref: RHEA:20133
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047723
name: inosinate nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + IMP = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, RHEA:20469]
synonym: "5'-inosinate phosphoribohydrolase activity" RELATED [EC:3.2.2.12]
xref: EC:3.2.2.12
xref: KEGG_REACTION:R01128
xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN
xref: RHEA:20469
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047724
name: inosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN]
synonym: "inosinase activity" RELATED [EC:3.2.2.2]
synonym: "inosine ribohydrolase activity" RELATED [EC:3.2.2.2]
synonym: "inosine-guanosine nucleosidase activity" RELATED [EC:3.2.2.2]
xref: EC:3.2.2.2
xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN
xref: RHEA:16657
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0047725
name: inulosucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9]
synonym: "sucrose 1-fructosyl transferase activity" RELATED [EC:2.4.1.9]
synonym: "sucrose 1-fructosyltransferase activity" RELATED [EC:2.4.1.9]
synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.9]
xref: EC:2.4.1.9
xref: MetaCyc:RXN-15518
xref: RHEA:15745
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047726
name: iron-cytochrome-c reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.98.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN]
synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" RELATED [EC:1.9.98.1]
synonym: "iron-cytochrome c reductase activity" RELATED [EC:1.9.98.1]
xref: EC:1.9.98.1
xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN
xref: RHEA:15617
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors

[Term]
id: GO:0047727
name: isobutyryl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA." [EC:5.4.99.13, RHEA:13141]
synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" RELATED [EC:5.4.99.13]
synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" RELATED [EC:5.4.99.13]
synonym: "isobutyryl coenzyme A mutase activity" RELATED [EC:5.4.99.13]
xref: EC:5.4.99.13
xref: KEGG_REACTION:R01181
xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN
xref: RHEA:13141
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047728
name: carnitine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH." [EC:1.1.1.108, RHEA:19265]
synonym: "carnitine:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.108]
xref: EC:1.1.1.108
xref: KEGG_REACTION:R02395
xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN
xref: RHEA:19265
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047729
name: carnitine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine + H+ = 2-methylcholine + CO2." [EC:4.1.1.42, RHEA:21576]
synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" RELATED [EC:4.1.1.42]
synonym: "carnitine carboxy-lyase activity" RELATED [EC:4.1.1.42]
xref: EC:4.1.1.42
xref: KEGG_REACTION:R02398
xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN
xref: RHEA:21576
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047730
name: carnosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [RHEA:19297]
synonym: "carnosine synthetase activity" RELATED [EC:6.3.2.11]
synonym: "carnosine-anserine synthetase activity" RELATED [EC:6.3.2.11]
synonym: "carnosine-homocarnosine synthetase activity" RELATED [EC:6.3.2.11]
synonym: "homocarnosine-carnosine synthetase activity" RELATED [EC:6.3.2.11]
synonym: "L-histidine:beta-alanine ligase (AMP-forming)" RELATED [EC:6.3.2.11]
xref: EC:6.3.2.11
xref: MetaCyc:CARNOSINE-SYNTHASE-RXN
xref: Reactome:R-HSA-6786245 "CARNS1 transforms ATP, L-His, b-Ala to CARN"
xref: RHEA:19297
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047731
name: catechol oxidase (dimerizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN]
synonym: "catechol:oxygen oxidoreductase (dimerizing)" RELATED [EC:1.1.3.14]
xref: EC:1.1.3.14
xref: MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN
xref: RHEA:12809
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047732
name: CDP-abequose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, RHEA:21656]
synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" RELATED [EC:5.1.3.10]
synonym: "CDP-D-abequose 2-epimerase activity" RELATED [EC:5.1.3.10]
synonym: "CDP-paratose 2-epimerase activity" RELATED [EC:5.1.3.10]
synonym: "CDP-paratose epimerase activity" RELATED [EC:5.1.3.10]
synonym: "CDP-tyvelose 2-epimerase activity" RELATED [EC:5.1.3.10]
synonym: "cytidine diphosphate paratose-2-epimerase activity" RELATED [EC:5.1.3.10]
synonym: "cytidine diphosphoabequose epimerase activity" RELATED [EC:5.1.3.10]
synonym: "cytidine diphosphodideoxyglucose epimerase activity" RELATED [EC:5.1.3.10]
synonym: "cytidine diphosphoparatose epimerase activity" RELATED [EC:5.1.3.10]
xref: EC:5.1.3.10
xref: KEGG_REACTION:R04266
xref: MetaCyc:RXN-9160
xref: RHEA:21656
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047733
name: CDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.45, RHEA:17153]
synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" RELATED [EC:4.2.1.45]
synonym: "CDP-glucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.45]
synonym: "CDPglucose 4,6-dehydratase activity" RELATED [EC:4.2.1.45]
synonym: "CDPglucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.45]
synonym: "cytidine diphosphoglucose oxidoreductase activity" RELATED [EC:4.2.1.45]
xref: EC:4.2.1.45
xref: KEGG_REACTION:R02426
xref: MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN
xref: RHEA:17153
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047734
name: CDP-glycerol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+." [EC:3.6.1.16, RHEA:21692]
synonym: "CDP-glycerol phosphoglycerohydrolase activity" RELATED [EC:3.6.1.16]
synonym: "CDP-glycerol pyrophosphatase activity" EXACT []
synonym: "CDPglycerol diphosphatase activity" RELATED [EC:3.6.1.16]
synonym: "CDPglycerol phosphoglycerohydrolase activity" RELATED [EC:3.6.1.16]
synonym: "CDPglycerol pyrophosphatase activity" RELATED [EC:3.6.1.16]
synonym: "cytidine diphosphoglycerol pyrophosphatase activity" RELATED [EC:3.6.1.16]
xref: EC:3.6.1.16
xref: KEGG_REACTION:R00855
xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN
xref: RHEA:21692
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047735
name: cellobiose dehydrogenase (acceptor) activity
namespace: molecular_function
alt_id: GO:0047737
def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN]
synonym: "CBOR activity" RELATED [EC:1.1.99.18]
synonym: "CDH activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18]
synonym: "cellobiose dehydrogenase activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose oxidase activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose oxidoreductase activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18]
synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.99.18]
synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" RELATED [EC:1.1.99.18]
xref: EC:1.1.99.18
xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:23484
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047736
name: cellobiose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN]
synonym: "cellobiose 2-epimerase activity" RELATED [EC:5.1.3.11]
xref: EC:5.1.3.11
xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN
xref: RHEA:23384
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047738
name: cellobiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [RHEA:19493]
synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.20]
xref: EC:2.4.1.20
xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN
xref: RHEA:19493
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0047739
name: cephalosporin-C deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cephalosporin C + H2O = acetate + deacetylcephalosporin C + H+." [EC:3.1.1.41, RHEA:22596]
synonym: "cephalosporin acetylesterase activity" RELATED [EC:3.1.1.41]
synonym: "cephalosporin C acetyl-esterase activity" RELATED [EC:3.1.1.41]
synonym: "cephalosporin C acetyl-hydrolase activity" RELATED [EC:3.1.1.41]
synonym: "cephalosporin C acetylase activity" RELATED [EC:3.1.1.41]
synonym: "cephalosporin C acetylesterase activity" RELATED [EC:3.1.1.41]
synonym: "cephalosporin C deacetylase activity" RELATED [EC:3.1.1.41]
synonym: "cephalosporin-C acetylhydrolase activity" RELATED [EC:3.1.1.41]
xref: EC:3.1.1.41
xref: KEGG_REACTION:R03062
xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN
xref: RHEA:22596
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047740
name: cephalosporin-C transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C." [EC:2.6.1.74, RHEA:14553]
synonym: "cephalosporin C aminotransferase activity" RELATED [EC:2.6.1.74]
synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.74]
synonym: "L-alanine:cephalosporin-C aminotransferase activity" RELATED [EC:2.6.1.74]
xref: EC:2.6.1.74
xref: KEGG_REACTION:R03063
xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN
xref: RHEA:14553
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047741
name: cetraxate benzylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+." [EC:3.1.1.70, RHEA:23460]
synonym: "cetraxate-benzyl-ester benzylhydrolase activity" RELATED [EC:3.1.1.70]
xref: EC:3.1.1.70
xref: KEGG_REACTION:R03612
xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN
xref: RHEA:23460
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047742
name: chenodeoxycholoyltaurine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN]
synonym: "chenodeoxycholoyltaurine amidohydrolase activity" RELATED [EC:3.5.1.74]
xref: EC:3.5.1.74
xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN
xref: RHEA:16309
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047743
name: chlordecone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH." [EC:1.1.1.225, RHEA:14401]
synonym: "CDR activity" RELATED [EC:1.1.1.225]
synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.225]
xref: EC:1.1.1.225
xref: KEGG_REACTION:R03716
xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN
xref: RHEA:14401
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047744
name: chloridazon-catechol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H+." [EC:1.13.11.36, RHEA:20449]
synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.36]
xref: EC:1.13.11.36
xref: KEGG_REACTION:R04602
xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN
xref: RHEA:20449
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047745
name: chlorogenate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorogenate + H2O = (-)-quinate + cis-caffeate + H+." [EC:3.1.1.42, RHEA:20689]
synonym: "chlorogenase activity" RELATED [EC:3.1.1.42]
synonym: "chlorogenic acid esterase activity" RELATED [EC:3.1.1.42]
xref: EC:3.1.1.42
xref: KEGG_REACTION:R02997
xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN
xref: RHEA:20689
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047746
name: chlorophyllase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [RHEA:19605]
synonym: "chlorophyll chlorophyllidohydrolase activity" RELATED [EC:3.1.1.14]
xref: EC:3.1.1.14
xref: MetaCyc:CHLOROPHYLLASE-RXN
xref: RHEA:19605
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047747
name: cholate-CoA ligase activity
namespace: molecular_function
alt_id: GO:0047477
def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates." [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT []
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.7]
synonym: "BAL activity" RELATED [EC:6.2.1.7]
synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.7]
synonym: "cholate thiokinase activity" RELATED [EC:6.2.1.7]
synonym: "cholate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.7]
synonym: "cholic acid:CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "cholic thiokinase activity" RELATED [EC:6.2.1.7]
synonym: "choloyl coenzyme A synthetase activity" RELATED [EC:6.2.1.7]
synonym: "choloyl-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "cholyl-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.7]
xref: EC:6.2.1.7
xref: MetaCyc:CHOLATE--COA-LIGASE-RXN
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047748
name: cholestanetetraol 26-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H+ + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]." [RHEA:34631]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT []
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT []
synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT []
synonym: "TEHC-NAD oxidoreductase activity" EXACT []
xref: EC:1.14.15.15
xref: MetaCyc:RXN-13690
xref: RHEA:34631
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047749
name: obsolete cholestanetriol 26-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [GOC:curators]
comment: This term was obsoleted because it represents a sub-reaction of cholestanetetraol 26-dehydrogenase activity ; GO:0047748.
synonym: "CYP27A" RELATED []
synonym: "CYP27A1" RELATED []
is_obsolete: true
replaced_by: GO:0047748

[Term]
id: GO:0047750
name: cholestenol delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [RHEA:15281]
synonym: "cholestenol D-isomerase activity" EXACT []
synonym: "delta7-cholestenol delta7-delta8-isomerase activity" RELATED [EC:5.3.3.5]
xref: EC:5.3.3.5
xref: MetaCyc:RXN66-25
xref: RHEA:15281
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0047751
name: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH." [RHEA:54384]
synonym: "3-oxosteroid 5alpha-reductase activity" RELATED [EC:1.3.1.22]
synonym: "3-oxosteroid delta4-dehydrogenase" BROAD []
synonym: "cholestenone 5-alpha-reductase activity" NARROW []
synonym: "cholestenone 5a-reductase activity" NARROW []
synonym: "cholestenone 5alpha-reductase activity" NARROW [EC:1.3.1.22]
synonym: "progesterone 5-alpha-reductase activity" NARROW []
synonym: "steroid 5alpha-hydrogenase activity" BROAD []
synonym: "steroid 5alpha-reductase" BROAD []
synonym: "sterol 5-alpha reductase activity" BROAD []
synonym: "testosterone 5alpha-reductase" NARROW []
synonym: "testosterone delta4-hydrogenase activity" NARROW []
xref: EC:1.3.1.22
xref: KEGG_REACTION:R02610
xref: MetaCyc:1.3.99.5-RXN
xref: RHEA:54384
is_a: GO:0003865 ! 3-oxo-5-alpha-steroid 4-dehydrogenase activity
is_a: GO:0035671 ! enone reductase activity

[Term]
id: GO:0047753
name: choline-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline sulfate + H2O = choline + H+ + sulfate." [EC:3.1.6.6, RHEA:20820]
synonym: "choline-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.6]
synonym: "choline-sulphatase activity" EXACT []
xref: EC:3.1.6.6
xref: KEGG_REACTION:R01028
xref: MetaCyc:CHOLINE-SULFATASE-RXN
xref: RHEA:20820
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047754
name: choline sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H+." [EC:2.8.2.6, RHEA:21984]
synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" RELATED [EC:2.8.2.6]
synonym: "choline sulphokinase activity" RELATED [EC:2.8.2.6]
synonym: "choline sulphotransferase activity" EXACT []
xref: EC:2.8.2.6
xref: KEGG_REACTION:R01027
xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN
xref: RHEA:21984
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047755
name: isocitrate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate." [EC:5.1.2.6, RHEA:10820]
synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" RELATED [EC:5.1.2.6]
xref: EC:5.1.2.6
xref: KEGG_REACTION:R02318
xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN
xref: RHEA:10820
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0047756
name: chondroitin 4-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" RELATED [EC:2.8.2.5]
synonym: "chondroitin 4-sulphotransferase activity" EXACT []
xref: EC:2.8.2.5
xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-1971483 "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13"
xref: RHEA:16101
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0047757
name: chondroitin-glucuronate 5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN]
synonym: "chondroitin D-glucuronosyl 5-epimerase activity" RELATED [EC:5.1.3.19]
synonym: "chondroitin-D-glucuronate 5-epimerase activity" RELATED [EC:5.1.3.19]
synonym: "dermatan-sulfate 5-epimerase activity" RELATED [EC:5.1.3.19]
synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19]
synonym: "urunosyl C-5 epimerase activity" RELATED [EC:5.1.3.19]
xref: EC:5.1.3.19
xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN
xref: Reactome:R-HSA-2022052 "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)"
xref: RHEA:21084
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047758
name: ATP:2-methylpropanoate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H+." [EC:2.7.2.14, RHEA:24156]
synonym: "ATP:2-methylpropanoate 1-phosphotransferase activity" EXACT []
synonym: "ATP:2-methylpropanoate kinase activity" EXACT []
synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" BROAD [EC:2.7.2.14, KEGG_REACTION:R04002]
synonym: "ATP:isobutyrate 1-phosphotransferase activity" EXACT []
synonym: "branched-chain fatty acid kinase activity" BROAD [EC:2.7.2.14]
synonym: "branched-chain-fatty-acid kinase activity" BROAD [EC:2.7.2.14]
synonym: "isobutyrate kinase activity" BROAD [EC:2.7.2.14]
xref: EC:2.7.2.14
xref: KEGG_REACTION:R04002
xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN
xref: RHEA:24156
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047759
name: butanal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN]
synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" RELATED [EC:1.2.1.57]
xref: EC:1.2.1.57
xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047760
name: obsolete butyrate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of medium-chain fatty acid-CoA ligase activity ; GO:0031956.
is_obsolete: true
replaced_by: GO:0031956

[Term]
id: GO:0047761
name: butyrate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H+." [EC:2.7.2.7, RHEA:13585]
synonym: "ATP:butanoate 1-phosphotransferase activity" RELATED [EC:2.7.2.7]
xref: EC:2.7.2.7
xref: KEGG_REACTION:R01688
xref: MetaCyc:BUTYRATE-KINASE-RXN
xref: RHEA:13585
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047762
name: caffeate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H+." [EC:1.13.11.22, RHEA:22216]
synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.22]
xref: EC:1.13.11.22
xref: KEGG_REACTION:R03365
xref: MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN
xref: RHEA:22216
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047763
name: caffeate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68]
synonym: "caffeate 3-O-methyltransferase activity" RELATED [EC:2.1.1.68]
synonym: "caffeate methyltransferase activity" RELATED [EC:2.1.1.68]
synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" RELATED [EC:2.1.1.68]
synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" RELATED [EC:2.1.1.68]
xref: EC:2.1.1.68
xref: MetaCyc:RXN-1104
xref: RHEA:20225
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047764
name: obsolete caldesmon kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators]
comment: This term was made obsolete because it represents a specific gene product.
is_obsolete: true

[Term]
id: GO:0047765
name: obsolete caldesmon-phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [PMID:6150036]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
consider: GO:0004721

[Term]
id: GO:0047766
name: carbamoyl-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-carbamoyl-L-serine + H2O + H+ = CO2 + 2 NH4 + pyruvate." [EC:4.3.1.13, RHEA:15445]
synonym: "carbamoylserine deaminase activity" RELATED [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" RELATED [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" RELATED [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine deaminase activity" RELATED [EC:4.3.1.13]
xref: EC:4.3.1.13
xref: KEGG_REACTION:R00213
xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN
xref: RHEA:15445
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047768
name: carboxy-cis,cis-muconate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, RHEA:14977]
synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" RELATED [EC:5.5.1.5]
synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" RELATED [EC:5.5.1.5]
synonym: "3-carboxymuconate cyclase activity" RELATED [EC:5.5.1.5]
xref: EC:5.5.1.5
xref: KEGG_REACTION:R03308
xref: MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN
xref: RHEA:14977
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047769
name: arogenate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91]
synonym: "carboxycyclohexadienyl dehydratase activity" EXACT []
synonym: "L-arogenate hydro-lyase (decarboxylating)" RELATED [EC:4.2.1.91]
synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" RELATED [EC:4.2.1.91]
xref: EC:4.2.1.91
xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN
xref: RHEA:12536
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047770
name: carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN]
synonym: "aldehyde:(acceptor) oxidoreductase activity" RELATED [EC:1.2.99.6]
synonym: "aldehyde:acceptor oxidoreductase activity" RELATED [EC:1.2.99.6]
synonym: "carboxylic acid reductase activity" RELATED [EC:1.2.99.6]
xref: EC:1.2.99.6
xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047771
name: carboxymethylhydantoinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate + H+." [EC:3.5.2.4, RHEA:12028]
synonym: "hydantoin hydrolase activity" RELATED [EC:3.5.2.4]
synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" RELATED [EC:3.5.2.4]
xref: EC:3.5.2.4
xref: KEGG_REACTION:R02284
xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN
xref: RHEA:12028
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047772
name: carboxymethyloxysuccinate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate." [EC:4.2.99.12, RHEA:12336]
synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" RELATED [EC:4.2.99.12]
synonym: "carboxymethyloxysuccinate glycolate-lyase activity" RELATED [EC:4.2.99.12]
xref: EC:4.2.99.12
xref: KEGG_REACTION:R01336
xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN
xref: RHEA:12336
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0047773
name: carnitinamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-carnitinamide + H2O = (R)-carnitine + NH4." [EC:3.5.1.73, RHEA:17537]
synonym: "carnitine amidase activity" RELATED [EC:3.5.1.73]
synonym: "L-carnitinamidase activity" RELATED [EC:3.5.1.73]
synonym: "L-carnitinamide amidohydrolase activity" RELATED [EC:3.5.1.73]
synonym: "L-carnitine amidase activity" RELATED [EC:3.5.1.73]
xref: EC:3.5.1.73
xref: KEGG_REACTION:R01922
xref: MetaCyc:CARNITINAMIDASE-RXN
xref: RHEA:17537
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047774
name: cis-2-enoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37]
synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" RELATED [EC:1.3.1.37]
synonym: "cis-2-enoyl-coenzyme A reductase activity" RELATED [EC:1.3.1.37]
synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" RELATED [EC:1.3.1.37]
synonym: "reductase, cis-2-enoyl coenzyme A" RELATED [EC:1.3.1.37]
xref: EC:1.3.1.37
xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047775
name: citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN]
synonym: "acetyl-CoA:citramalate CoA-transferase activity" RELATED [EC:2.8.3.11]
xref: EC:2.8.3.11
xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN
xref: RHEA:17621
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047776
name: citramalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-citramalate = acetate + pyruvate." [EC:4.1.3.22, RHEA:15545]
synonym: "(+)-citramalate pyruvate-lyase activity" RELATED [EC:4.1.3.22]
synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" RELATED [EC:4.1.3.22]
synonym: "(3S)-citramalate pyruvate-lyase activity" RELATED [EC:4.1.3.22]
synonym: "(S)-citramalate lyase activity" RELATED [EC:4.1.3.22]
synonym: "citramalate pyruvate lyase activity" RELATED [EC:4.1.3.22]
synonym: "citramalate pyruvate-lyase activity" RELATED [EC:4.1.3.22]
synonym: "citramalate synthetase activity" RELATED [EC:4.1.3.22]
synonym: "citramalic synthase activity" RELATED [EC:4.1.3.22]
synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22]
xref: EC:4.1.3.22
xref: KEGG_REACTION:R00325
xref: MetaCyc:CITRAMALATE-LYASE-RXN
xref: RHEA:15545
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047777
name: (S)-citramalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, RHEA:22612]
synonym: "(+)-CMA-CoA lyase activity" RELATED [EC:4.1.3.25]
synonym: "(3S)-citramalyl-CoA lyase activity" RELATED [EC:4.1.3.25]
synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.25]
synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" RELATED [EC:4.1.3.25]
synonym: "citramalyl coenzyme A lyase activity" RELATED [EC:4.1.3.25]
synonym: "citramalyl-CoA lyase activity" BROAD []
xref: EC:4.1.3.25
xref: KEGG_REACTION:R00237
xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN
xref: RHEA:22612
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047778
name: [citrate-(pro-3S)-lyase] thiolesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN]
synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" RELATED [EC:3.1.2.16]
synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT []
synonym: "citrate lyase deacetylase activity" RELATED [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase thioesterase activity" RELATED [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase thiolesterase activity" RELATED [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" RELATED [EC:3.1.2.16]
xref: EC:3.1.2.16
xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN
xref: RHEA:13657
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0047779
name: citrate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H+ + phosphate." [EC:6.2.1.18, RHEA:21472]
synonym: "citrate thiokinase activity" RELATED [EC:6.2.1.18]
synonym: "citrate:CoA ligase (ADP-forming)" RELATED [EC:6.2.1.18]
synonym: "citrate:CoA ligase activity" RELATED [EC:6.2.1.18]
synonym: "citryl-CoA synthetase activity" RELATED [EC:6.2.1.18]
xref: EC:6.2.1.18
xref: KEGG_REACTION:R01322
xref: MetaCyc:CITRATE--COA-LIGASE-RXN
xref: RHEA:21472
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047780
name: obsolete citrate dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.3]
comment: This term was obsoleted because it represents a sub-reaction of aconitate hydratase activity ; GO:0003994.
synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3]
synonym: "citrate hydro-lyase (cis-aconitate-forming)" RELATED [EC:4.2.1.3]
synonym: "citrate hydro-lyase (cis-aconitate-forming) activity" EXACT []
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3]
is_obsolete: true
replaced_by: GO:0003994

[Term]
id: GO:0047781
name: citrullinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN]
synonym: "citrulline hydrolase activity" RELATED [EC:3.5.1.20]
synonym: "citrulline ureidase activity" RELATED [EC:3.5.1.20]
synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" RELATED [EC:3.5.1.20]
synonym: "L-citrulline N5-carbamoyldihydrolase activity" RELATED [EC:3.5.1.20]
xref: EC:3.5.1.20
xref: MetaCyc:CITRULLINASE-RXN
xref: RHEA:11940
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047782
name: coniferin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN]
synonym: "coniferin b-glucosidase activity" EXACT []
synonym: "coniferin beta-D-glucosidase activity" RELATED [EC:3.2.1.126]
synonym: "coniferin-hydrolyzing beta-glucosidase activity" RELATED [EC:3.2.1.126]
xref: EC:3.2.1.126
xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:12252
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0047783
name: corticosterone 18-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5]
synonym: "corticosterone 18-hydroxylase activity" EXACT []
synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5]
synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" RELATED [EC:1.14.15.5]
xref: EC:1.14.15.5
xref: MetaCyc:RXN66-360
xref: RHEA:11872
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047784
name: cortisol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, RHEA:17073]
synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" RELATED [EC:2.3.1.27]
synonym: "corticosteroid acetyltransferase activity" RELATED [EC:2.3.1.27]
synonym: "corticosteroid-21-O-acetyltransferase activity" RELATED [EC:2.3.1.27]
synonym: "cortisol acetyltransferase activity" RELATED [EC:2.3.1.27]
xref: EC:2.3.1.27
xref: KEGG_REACTION:R02837
xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN
xref: RHEA:17073
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047785
name: cortisol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H+." [EC:2.8.2.18, RHEA:11884]
synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" RELATED [EC:2.8.2.18]
synonym: "cortisol sulphotransferase activity" EXACT []
synonym: "glucocorticoid sulfotransferase activity" RELATED [EC:2.8.2.18]
synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18]
xref: EC:2.8.2.18
xref: KEGG_REACTION:R02839
xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN
xref: RHEA:11884
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047786
name: obsolete cortisone alpha-reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4,5alpha-dihydrocortisone + NADP+ = cortisone + H+ + NADPH." [GOC:curators]
comment: RHEA: not enough evidence that the activity exists
synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" RELATED []
synonym: "cortisone a-reductase activity" EXACT []
synonym: "cortisone delta4-5alpha-reductase activity" RELATED []
synonym: "delta4-3-ketosteroid reductase (5alpha)" RELATED []
synonym: "delta4-3-oxosteroid-5alpha-reductase" RELATED []
synonym: "delta4-5alpha-reductase activity" RELATED []
synonym: "microsomal steroid reductase (5alpha)" RELATED []
synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" RELATED []
is_obsolete: true

[Term]
id: GO:0047787
name: Delta4-3-oxosteroid 5beta-reductase activity
namespace: molecular_function
alt_id: GO:0047752
def: "Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates." [EC:1.3.1.3]
synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.3]
synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.3]
synonym: "3-oxo-Delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.3]
synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" NARROW [EC:1.3.1.3]
synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.3]
synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" NARROW [EC:1.3.1.3]
synonym: "5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "androstenedione 5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "androstenedione 5beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cholestenone 5-beta-reductase activity" NARROW []
synonym: "cholestenone 5b-reductase activity" NARROW []
synonym: "cholestenone 5beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone 5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone 5beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone b-reductase activity" NARROW []
synonym: "cortisone beta-reductase activity" NARROW []
synonym: "cortisone delta(4)-5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone delta4-5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta(4)-3-ketosteroid 5-beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta(4)-5-beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta(4)-hydrogenase activity" RELATED [EC:1.3.1.3]
synonym: "Delta4-3-ketosteroid 5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta4-3-oxosteroid 5-beta-reductase activity" EXACT []
synonym: "Delta4-5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta4-hydrogenase activity" RELATED [EC:1.3.1.3]
synonym: "steroid 5-beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "steroid 5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "testosterone 5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "testosterone 5beta-reductase activity" NARROW [EC:1.3.1.3]
xref: EC:1.3.1.3
xref: MetaCyc:RXN-23672
xref: RHEA:54412
is_a: GO:0035671 ! enone reductase activity

[Term]
id: GO:0047788
name: 2-coumarate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = trans-2-coumarate + H+ + NADH." [EC:1.3.1.11, RHEA:21444]
synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.11]
synonym: "coumarate reductase activity" EXACT []
synonym: "melilotate dehydrogenase activity" RELATED [EC:1.3.1.11]
xref: EC:1.3.1.11
xref: KEGG_REACTION:R03709
xref: MetaCyc:COUMARATE-REDUCTASE-RXN
xref: RHEA:21444
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047789
name: creatininase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatinine + H2O = creatine." [EC:3.5.2.10, RHEA:14533]
synonym: "creatinine amidohydrolase activity" RELATED [EC:3.5.2.10]
synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10]
xref: EC:3.5.2.10
xref: KEGG_REACTION:R01884
xref: MetaCyc:CREATININASE-RXN
xref: RHEA:14533
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047790
name: creatinine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN]
synonym: "creatinine desiminase activity" RELATED [EC:3.5.4.21]
synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21]
synonym: "creatinine iminohydrolase activity" RELATED [EC:3.5.4.21]
xref: EC:3.5.4.21
xref: MetaCyc:CREATININE-DEAMINASE-RXN
xref: RHEA:12681
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047791
name: cucurbitacin Delta23 reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5]
synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" RELATED [EC:1.3.1.5]
synonym: "cucurbitacin D23-reductase activity" EXACT []
synonym: "cucurbitacin delta(23) reductase activity" EXACT []
synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" RELATED [EC:1.3.1.5]
xref: EC:1.3.1.5
xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047792
name: cyanohydrin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85]
synonym: "cyanohydrin b-glucosyltransferase activity" EXACT []
synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.85]
synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.85]
synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.85]
synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" RELATED [EC:2.4.1.85]
synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85]
synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.85]
synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.85]
synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" RELATED [EC:2.4.1.85]
xref: EC:2.4.1.85
xref: MetaCyc:RXN-743
xref: RHEA:12853
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047793
name: cycloeucalenol cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, RHEA:22800]
synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" RELATED [EC:5.5.1.9]
synonym: "cycloeucalenol--obtusifoliol isomerase activity" RELATED [EC:5.5.1.9]
synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT []
xref: EC:5.5.1.9
xref: KEGG_REACTION:R03775
xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN
xref: RHEA:22800
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047794
name: cyclohexadienyl dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43]
synonym: "arogenate dehydrogenase activity" RELATED [EC:1.3.1.43]
synonym: "arogenic dehydrogenase activity" RELATED [EC:1.3.1.43]
synonym: "L-arogenate:NAD(+) oxidoreductase activity" RELATED [EC:1.3.1.43]
synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.43]
synonym: "L-arogenate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.43]
synonym: "pretyrosine dehydrogenase activity" RELATED [EC:1.3.1.43]
xref: EC:1.3.1.43
xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN
xref: RHEA:12256
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047795
name: cyclohexane-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN]
synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.174]
xref: EC:1.1.1.174
xref: MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN
xref: RHEA:18141
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047796
name: cyclohexane-1,3-dione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H+." [EC:3.7.1.10, RHEA:16473]
synonym: "1,3-cyclohexanedione hydrolase activity" RELATED [EC:3.7.1.10]
synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" RELATED [EC:3.7.1.10]
xref: EC:3.7.1.10
xref: KEGG_REACTION:R03211
xref: MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN
xref: RHEA:16473
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047797
name: cyclohexanone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone." [EC:1.3.99.14, RHEA:21780]
synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.3.99.14]
synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" RELATED [EC:1.3.99.14]
xref: EC:1.3.99.14
xref: KEGG_REACTION:R02234
xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN
xref: RHEA:21780
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047798
name: cyclomaltodextrinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN]
synonym: "cyclodextrinase activity" RELATED [EC:3.2.1.54]
synonym: "cycloheptaglucanase activity" RELATED [EC:3.2.1.54]
synonym: "cyclohexaglucanase activity" RELATED [EC:3.2.1.54]
synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" RELATED [EC:3.2.1.54]
xref: EC:3.2.1.54
xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN
xref: RHEA:23980
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047799
name: cyclopentanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopentanone + H+ + NADPH + O2 = 5-valerolactone + H2O + NADP+." [EC:1.14.13.16, RHEA:15737]
synonym: "cyclopentanone 1,2-monooxygenase activity" RELATED [EC:1.14.13.16]
synonym: "cyclopentanone oxygenase activity" RELATED [EC:1.14.13.16]
synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" RELATED [EC:1.14.13.16]
xref: EC:1.14.13.16
xref: KEGG_REACTION:R02554
xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN
xref: RHEA:15737
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047800
name: cysteamine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine." [EC:1.13.11.19, RHEA:14409]
synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" RELATED [EC:1.13.11.19]
synonym: "cysteamine oxygenase activity" RELATED [EC:1.13.11.19]
synonym: "cysteamine:oxygen oxidoreductase activity" RELATED [EC:1.13.11.19]
synonym: "persulfurase activity" RELATED [EC:1.13.11.19]
xref: EC:1.13.11.19
xref: KEGG_REACTION:R02467
xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN
xref: Reactome:R-HSA-6814153 "ADO oxidises 2AET to HTAU"
xref: RHEA:14409
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047801
name: L-cysteine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [RHEA:17441]
synonym: "cysteine aminotransferase activity" BROAD []
synonym: "cysteine transaminase activity" EXACT [EC:2.6.1.3]
synonym: "L-cysteine:2-oxoglutarate aminotransferase activity" EXACT []
xref: EC:2.6.1.3
xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-9012597 "GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu"
xref: RHEA:17441
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047802
name: cysteine-conjugate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate." [EC:2.6.1.75, RHEA:13485]
synonym: "cysteine conjugate aminotransferase activity" RELATED [EC:2.6.1.75]
synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" RELATED [EC:2.6.1.75]
synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.75]
xref: EC:2.6.1.75
xref: KEGG_REACTION:R04338
xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN
xref: RHEA:13485
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047803
name: cysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN]
synonym: "cysteine (sulfite) lyase activity" RELATED [EC:4.4.1.10]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" RELATED [EC:4.4.1.10]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" RELATED [EC:4.4.1.10]
xref: EC:4.4.1.10
xref: MetaCyc:CYSTEINE-LYASE-RXN
xref: RHEA:20916
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047804
name: cysteine-S-conjugate beta-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-substituted L-cysteine + H2O = a thiol + NH4+ + pyruvate." [RHEA:18121]
synonym: "alkylcysteine lyase activity" RELATED [EC:4.4.1.13]
synonym: "cystathionine beta-lyase activity" RELATED [EC:4.4.1.13]
synonym: "cysteine conjugate beta-lyase activity" RELATED [EC:4.4.1.13]
synonym: "cysteine-S-conjugate b-lyase activity" EXACT []
synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" RELATED [EC:4.4.1.13]
synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" RELATED [EC:4.4.1.13]
synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.4.1.13]
synonym: "S-alkylcysteine lyase activity" RELATED [EC:4.4.1.13]
xref: EC:4.4.1.13
xref: MetaCyc:RXN-6763
xref: RHEA:18121
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047805
name: cytidylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+." [RHEA:14737]
synonym: "3',5'-cyclic-CMP synthase activity" RELATED [EC:4.6.1.6]
synonym: "3'5'-cyclic-CMP synthase activity" RELATED [EC:4.6.1.6]
synonym: "CTP diphosphate-lyase (cyclizing)" RELATED [EC:4.6.1.6]
synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" RELATED [EC:4.6.1.6]
synonym: "cytidyl cyclase activity" RELATED [EC:4.6.1.6]
synonym: "cytidylyl cyclase activity" RELATED [EC:4.6.1.6]
xref: EC:4.6.1.6
xref: KEGG_REACTION:R00574
xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN
xref: RHEA:14737
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0047806
name: cytochrome-c3 hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN]
synonym: "cytochrome c3 reductase activity" RELATED [EC:1.12.2.1]
synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1]
synonym: "H(2):ferricytochrome c3 oxidoreductase activity" RELATED [EC:1.12.2.1]
synonym: "H2:ferricytochrome c3 oxidoreductase activity" RELATED [EC:1.12.2.1]
synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" RELATED [EC:1.12.2.1]
xref: EC:1.12.2.1
xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN
xref: RHEA:20625
is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor

[Term]
id: GO:0047807
name: cytokinin 7-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT []
synonym: "cytokinin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118]
synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118]
synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118]
synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118]
synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118]
xref: EC:2.4.1.118
xref: KEGG_REACTION:R04071
xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:23272
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047808
name: D(-)-tartrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tartrate = H2O + oxaloacetate." [EC:4.2.1.81, RHEA:18289]
synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" RELATED [EC:4.2.1.81]
synonym: "(S,S)-tartrate hydro-lyase activity" RELATED [EC:4.2.1.81]
synonym: "D-tartrate dehydratase activity" RELATED [EC:4.2.1.81]
xref: EC:4.2.1.81
xref: KEGG_REACTION:R00340
xref: MetaCyc:D--TARTRATE-DEHYDRATASE-RXN
xref: RHEA:18289
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047809
name: D-2-hydroxy-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate." [EC:1.1.99.6, RHEA:15089]
synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.99.6]
synonym: "2-hydroxy acid dehydrogenase activity" RELATED [EC:1.1.99.6]
xref: EC:1.1.99.6
xref: KEGG_REACTION:R00297
xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN
xref: RHEA:15089
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047810
name: D-alanine-2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21]
synonym: "D-alanine aminotransferase activity" EXACT []
synonym: "D-alanine transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-alanine-D-glutamate transaminase activity" RELATED [EC:2.6.1.21]
synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21]
synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-amino-acid transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21]
synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21]
synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21]
xref: EC:2.6.1.21
xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN
xref: RHEA:15869
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047811
name: D-alanine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4." [RHEA:23556]
synonym: "D-alanine g-glutamyltransferase activity" EXACT []
xref: EC:2.3.2.14
xref: KEGG_REACTION:R01149
xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN
xref: RHEA:23556
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0047812
name: D-amino-acid N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36]
synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" RELATED [EC:2.3.1.36]
synonym: "D-amino acid acetyltransferase activity" RELATED [EC:2.3.1.36]
synonym: "D-amino acid-alpha-N-acetyltransferase activity" RELATED [EC:2.3.1.36]
xref: EC:2.3.1.36
xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN
xref: RHEA:20704
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047813
name: D-arabinitol 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN]
xref: EC:1.1.1.11
xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN
xref: RHEA:17921
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047814
name: D-arabinokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP." [EC:2.7.1.54, RHEA:24588]
synonym: "ATP:D-arabinose 5-phosphotransferase activity" RELATED [EC:2.7.1.54]
synonym: "D-arabinokinase (phosphorylating)" RELATED [EC:2.7.1.54]
xref: EC:2.7.1.54
xref: KEGG_REACTION:R01573
xref: MetaCyc:D-ARABINOKINASE-RXN
xref: RHEA:24588
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047815
name: D-arabinonolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate + H+." [EC:3.1.1.30, RHEA:23108]
synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.30]
xref: EC:3.1.1.30
xref: KEGG_REACTION:R02714
xref: MetaCyc:D-ARABINONOLACTONASE-RXN
xref: RHEA:23108
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047816
name: D-arabinose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [RHEA:20457]
synonym: "arabinose(fucose)dehydrogenase activity" RELATED [EC:1.1.1.116]
synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.116]
synonym: "NAD-pentose-dehydrogenase activity" RELATED [EC:1.1.1.116]
xref: EC:1.1.1.116
xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN
xref: RHEA:20457
is_a: GO:0045290 ! D-arabinose 1-dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0047817
name: D-arginase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea." [EC:3.5.3.10, RHEA:12901]
synonym: "D-arginine amidinohydrolase activity" RELATED [EC:3.5.3.10]
xref: EC:3.5.3.10
xref: KEGG_REACTION:R02458
xref: MetaCyc:D-ARGINASE-RXN
xref: RHEA:12901
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047818
name: D-fuconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O." [EC:4.2.1.67, RHEA:12949]
synonym: "D-fuconate hydratase activity" EXACT []
synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" RELATED [EC:4.2.1.67]
synonym: "D-fuconate hydro-lyase activity" RELATED [EC:4.2.1.67]
xref: EC:4.2.1.67
xref: KEGG_REACTION:R03671
xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN
xref: RHEA:12949
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047819
name: D-glutamate(D-aspartate) oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.15]
comment: For the individual reactions, see instead 'D-glutamate oxidase activity ;GO:0047821' and 'D-aspartate oxidase activity ; GO:0008445'.
synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.15]
synonym: "D-glutamic-aspartic oxidase activity" RELATED [EC:1.4.3.15]
synonym: "D-monoaminodicarboxylic acid oxidase activity" RELATED [EC:1.4.3.15]
xref: EC:1.4.3.15
is_a: GO:0003884 ! D-amino-acid oxidase activity

[Term]
id: GO:0047820
name: D-glutamate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [RHEA:22360]
synonym: "D-glutamate hydro-lyase (cyclizing)" RELATED [EC:4.2.1.48]
synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" RELATED [EC:4.2.1.48]
xref: EC:4.2.1.48
xref: KEGG_REACTION:R01583
xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN
xref: RHEA:22360
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047821
name: D-glutamate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4+." [RHEA:10028]
synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.7]
synonym: "D-glutamic acid oxidase activity" RELATED [EC:1.4.3.7]
synonym: "D-glutamic oxidase activity" RELATED [EC:1.4.3.7]
xref: EC:1.4.3.7
xref: KEGG_REACTION:R00279
xref: RHEA:10028
is_a: GO:0003884 ! D-amino-acid oxidase activity

[Term]
id: GO:0047822
name: hypotaurine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine." [RHEA:69819]
synonym: "hypotaurine dehydrogenase activity" EXACT []
xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-1655453 "FMO1:FAD oxidizes HTAU to TAU"
xref: RHEA:69819
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047823
name: D-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4+. Can also transfer additional glutamyl residues to a peptide, extending the polypeptide chain." [EC:2.3.2.1]
synonym: "D-gamma-glutamyl transpeptidase activity" RELATED [EC:2.3.2.1]
synonym: "D-glutamyl transpeptidase activity" RELATED [EC:2.3.2.1]
synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" RELATED [EC:2.3.2.1]
xref: EC:2.3.2.1
xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN
xref: RHEA:35623
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0047824
name: D-iditol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [RHEA:12725]
xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN
xref: RHEA:12725
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0047825
name: D-lactate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-O-sulfolactate + H2O = (R)-lactate + H+ + sulfate." [EC:3.1.6.17, RHEA:20337]
synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" RELATED [EC:3.1.6.17]
synonym: "D-lactate-2-sulphatase activity" EXACT []
xref: EC:3.1.6.17
xref: KEGG_REACTION:R01448
xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN
xref: RHEA:20337
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047826
name: D-lysine 5,6-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine = (2R,5S)-2,5-diaminohexanoate and (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3]
synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" RELATED [EC:5.4.3.3]
synonym: "lysine 5,6-aminomutase activity" RELATED []
xref: EC:5.4.3.3
xref: KEGG_REACTION:R02852
xref: MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN
is_a: GO:0016869 ! intramolecular aminotransferase activity

[Term]
id: GO:0047827
name: D-lysopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysopine + H2O + NADP+ = L-lysine + H+ + NADPH + pyruvate." [EC:1.5.1.16, RHEA:17625]
synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.16]
synonym: "D(+)-lysopine dehydrogenase activity" RELATED [EC:1.5.1.16]
synonym: "D-lysopine synthase activity" RELATED [EC:1.5.1.16]
synonym: "lysopine dehydrogenase activity" RELATED [EC:1.5.1.16]
synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.16]
xref: EC:1.5.1.16
xref: KEGG_REACTION:R00452
xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN
xref: RHEA:17625
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047828
name: D-lyxose ketol-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, RHEA:14201]
synonym: "D-lyxose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.15]
synonym: "D-lyxose isomerase activity" RELATED [EC:5.3.1.15]
xref: EC:5.3.1.15
xref: KEGG_REACTION:R01898
xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN
xref: RHEA:14201
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0047829
name: D-nopaline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN]
synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.19]
synonym: "D-nopaline synthase activity" RELATED [EC:1.5.1.19]
synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.19]
synonym: "nopaline dehydrogenase activity" RELATED [EC:1.5.1.19]
synonym: "nopaline synthase activity" RELATED [EC:1.5.1.19]
synonym: "NOS activity" RELATED [EC:1.5.1.19]
xref: EC:1.5.1.19
xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN
xref: RHEA:19637
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047830
name: D-octopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN]
synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.11]
synonym: "D-octopine synthase activity" RELATED [EC:1.5.1.11]
synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.11]
synonym: "octopine dehydrogenase activity" RELATED [EC:1.5.1.11]
synonym: "octopine:NAD oxidoreductase activity" RELATED [EC:1.5.1.11]
synonym: "ODH activity" RELATED [EC:1.5.1.11]
xref: EC:1.5.1.11
xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN
xref: RHEA:16285
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047831
name: D-ornithine 4,5-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [RHEA:14893]
synonym: "D-alpha-ornithine 5,4-aminomutase activity" RELATED [EC:5.4.3.5]
synonym: "D-ornithine aminomutase activity" RELATED [EC:5.4.3.5]
xref: EC:5.4.3.5
xref: KEGG_REACTION:R02461
xref: MetaCyc:ORNMUTST-RXN
xref: RHEA:14893
is_a: GO:0016869 ! intramolecular aminotransferase activity

[Term]
id: GO:0047832
name: D-pinitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADPH." [EC:1.1.1.142, RHEA:20437]
synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.142]
synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.142]
xref: EC:1.1.1.142
xref: KEGG_REACTION:R03498
xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN
xref: RHEA:20437
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047833
name: D-sorbitol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN]
synonym: "D-sorbitol dehydrogenase activity" EXACT []
synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.21]
synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.21]
xref: EC:1.1.99.21
xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN
xref: RHEA:21320
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047834
name: D-threo-aldose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN]
synonym: "(2S,3R)-aldose dehydrogenase activity" RELATED [EC:1.1.1.122]
synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.122]
synonym: "dehydrogenase, L-fucose" RELATED [EC:1.1.1.122]
synonym: "L-fucose (D-arabinose) dehydrogenase activity" RELATED [EC:1.1.1.122]
synonym: "L-fucose dehydrogenase activity" RELATED [EC:1.1.1.122]
xref: EC:1.1.1.122
xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN
xref: RHEA:19645
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047835
name: D-tryptophan N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H+." [RHEA:10060]
synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" RELATED [EC:2.3.1.34]
synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" RELATED [EC:2.3.1.34]
synonym: "D-tryptophan acetyltransferase activity" RELATED [EC:2.3.1.34]
xref: EC:2.3.1.34
xref: KEGG_REACTION:R02481
xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN
xref: RHEA:10060
is_a: GO:0047812 ! D-amino-acid N-acetyltransferase activity

[Term]
id: GO:0047836
name: D-tryptophan N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H+." [EC:2.3.1.112, RHEA:23320]
synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" RELATED [EC:2.3.1.112]
xref: EC:2.3.1.112
xref: KEGG_REACTION:R02482
xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN
xref: RHEA:23320
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047837
name: D-xylose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH." [RHEA:22000]
synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.179]
synonym: "D-xylose-NADP dehydrogenase activity" RELATED [EC:1.1.1.179]
synonym: "D-xylose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.179]
synonym: "D-xylose:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.179]
xref: EC:1.1.1.179
xref: KEGG_REACTION:R01430
xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:22000
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047838
name: D-xylose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [RHEA:13861]
synonym: "(NAD)-linked D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175]
synonym: "D-xylose 1-dehydrogenase (NAD) activity" EXACT []
synonym: "D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175]
synonym: "D-xylose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.175]
synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175]
synonym: "NAD-D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175]
synonym: "NAD-linked D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175]
xref: EC:1.1.1.175
xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN
xref: RHEA:13861
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047839
name: dATP(dGTP)-DNA purinetransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1]
synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT []
synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" RELATED [EC:2.6.99.1]
xref: EC:2.6.99.1
xref: MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0047840
name: dCTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate." [RHEA:22636]
synonym: "dCTP nucleotidohydrolase activity" RELATED [EC:3.6.1.12]
synonym: "dCTP pyrophosphatase activity" EXACT []
synonym: "dCTPase activity" RELATED [EC:3.6.1.12]
synonym: "deoxy-CTPase activity" RELATED [EC:3.6.1.12]
synonym: "deoxycytidine triphosphatase activity" RELATED [EC:3.6.1.12]
synonym: "deoxycytidine-triphosphatase activity" RELATED [EC:3.6.1.12]
xref: EC:3.6.1.12
xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN
xref: Reactome:R-HSA-6786257 "DCTPP1 hydrolyses 5idCTP"
xref: RHEA:22636
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0047841
name: dehydrogluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H+." [EC:2.7.1.13, RHEA:10788]
synonym: "2-ketogluconate kinase activity" RELATED [EC:2.7.1.13]
synonym: "2-ketogluconokinase activity" RELATED [EC:2.7.1.13]
synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.13]
synonym: "dehydogluconokinase activity" EXACT []
synonym: "ketogluconokinase (phosphorylating)" RELATED [EC:2.7.1.13]
synonym: "ketogluconokinase activity" RELATED [EC:2.7.1.13]
xref: EC:2.7.1.13
xref: KEGG_REACTION:R02658
xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN
xref: RHEA:10788
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047842
name: dehydro-L-gulonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2." [EC:4.1.1.34, RHEA:11084]
synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" RELATED [EC:4.1.1.34]
synonym: "3-dehydro-L-gulonate carboxy-lyase activity" RELATED [EC:4.1.1.34]
synonym: "3-keto-L-gulonate decarboxylase activity" RELATED [EC:4.1.1.34]
synonym: "keto-L-gulonate decarboxylase activity" RELATED [EC:4.1.1.34]
xref: EC:4.1.1.34
xref: KEGG_REACTION:R01905
xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN
xref: Reactome:R-HSA-5662473 "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose"
xref: RHEA:11084
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047843
name: dehydrogluconate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)." [EC:1.1.99.4, RHEA:12368]
synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.4]
synonym: "2-keto-D-gluconate dehydrogenase activity" RELATED [EC:1.1.99.4]
synonym: "2-oxogluconate dehydrogenase activity" RELATED [EC:1.1.99.4]
synonym: "alpha-ketogluconate dehydrogenase activity" RELATED [EC:1.1.99.4]
synonym: "ketogluconate dehydrogenase activity" RELATED [EC:1.1.99.4]
xref: EC:1.1.99.4
xref: KEGG_REACTION:R07153
xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN
xref: RHEA:12368
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047844
name: obsolete deoxycytidine deaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [GOC:curators]
comment: The reason for obsoletion is that this molecular function is equivalent to GO:0004126 cytidine deaminase activity, per EC:3.5.4.5.
synonym: "deoxycytidine aminohydrolase activity" RELATED [EC:3.5.4.14]
is_obsolete: true
replaced_by: GO:0004126

[Term]
id: GO:0047845
name: deoxylimonate A-ring-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H+." [EC:3.1.1.46, RHEA:14997]
synonym: "deoxylimonate A-ring-lactonohydrolase activity" RELATED [EC:3.1.1.46]
xref: EC:3.1.1.46
xref: KEGG_REACTION:R03803
xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN
xref: RHEA:14997
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047846
name: deoxynucleotide 3'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN]
synonym: "3'-deoxynucleotidase activity" RELATED [EC:3.1.3.34]
synonym: "3'-deoxyribonucleotidase activity" RELATED [EC:3.1.3.34]
synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" RELATED [EC:3.1.3.34]
xref: EC:3.1.3.34
xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN
xref: RHEA:10092
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047847
name: deoxyuridine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil." [RHEA:22824]
xref: MetaCyc:URA-PHOSPH-RXN
xref: RHEA:22824
is_a: GO:0016154 ! pyrimidine-nucleoside phosphorylase activity

[Term]
id: GO:0047848
name: obsolete dephospho-[reductase kinase] kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN]
comment: The reason for obsoletion is that there are no proteins associated with this EC, and this reaction is not found in RHEA.
synonym: "AMP-activated kinase activity" RELATED []
synonym: "AMP-activated protein kinase kinase activity" RELATED []
synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" RELATED []
synonym: "dephospho-reductase kinase kinase activity" RELATED []
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" RELATED []
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" RELATED []
synonym: "reductase kinase activity" BROAD []
synonym: "reductase kinase kinase activity" RELATED []
synonym: "STK30" RELATED []
is_obsolete: true

[Term]
id: GO:0047849
name: dextransucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose." [RHEA:18825]
synonym: "CEP" RELATED [EC:2.4.1.5]
synonym: "SGE" RELATED [EC:2.4.1.5]
synonym: "sucrose 6-glucosyltransferase activity" RELATED [EC:2.4.1.5]
synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" RELATED [EC:2.4.1.5]
synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.5]
xref: EC:2.4.1.5
xref: MetaCyc:2.4.1.125-RXN
xref: RHEA:18825
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0047850
name: diaminopimelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H2O + NADP+ = L-2-amino-6-oxopimelate + H+ + NADPH + NH4." [EC:1.4.1.16, RHEA:13561]
synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.16]
synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" RELATED [EC:1.4.1.16]
synonym: "meso-diaminopimelate D-dehydrogenase activity" RELATED [EC:1.4.1.16]
synonym: "meso-diaminopimelate dehydrogenase activity" RELATED [EC:1.4.1.16]
xref: EC:1.4.1.16
xref: KEGG_REACTION:R02755
xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN
xref: RHEA:13561
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047851
name: dicarboxylate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN]
synonym: "carboxylyl-CoA synthetase activity" RELATED [EC:6.2.1.23]
synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.23]
xref: EC:6.2.1.23
xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN
xref: RHEA:14289
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047852
name: diferric-transferrin reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [RHEA:13841]
synonym: "diferric transferrin reductase activity" RELATED [EC:1.16.1.2]
synonym: "NADH diferric transferrin reductase activity" RELATED [EC:1.16.1.2]
synonym: "transferrin reductase activity" RELATED [EC:1.16.1.2]
synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" RELATED [EC:1.16.1.2]
xref: EC:1.16.1.2
xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN
xref: RHEA:13841
is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[Term]
id: GO:0047853
name: difructose-anhydride synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN, RHEA:15041]
synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" RELATED [EC:4.2.1.179]
synonym: "inulobiose hydrolase activity" RELATED [EC:4.2.1.179]
xref: EC:4.2.1.179
xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN
xref: RHEA:15041
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047854
name: diguanidinobutanase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea." [EC:3.5.3.20, RHEA:13597]
synonym: "1,4-diguanidinobutane amidinohydrolase activity" RELATED [EC:3.5.3.20]
xref: EC:3.5.3.20
xref: KEGG_REACTION:R01418
xref: MetaCyc:DIGUANIDINOBUTANASE-RXN
xref: RHEA:13597
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047855
name: dihydrobunolol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrobunolol + NADP+ = bunolol + H+ + NADPH." [EC:1.1.1.160, RHEA:15925]
synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.160]
synonym: "bunolol reductase activity" RELATED [EC:1.1.1.160]
xref: EC:1.1.1.160
xref: KEGG_REACTION:R04623
xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN
xref: RHEA:15925
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047856
name: dihydrocoumarin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+." [RHEA:10360]
synonym: "3,4-dihydrocoumarin hydrolase activity" EXACT []
synonym: "dihydrocoumarin lactonohydrolase activity" RELATED [EC:3.1.1.35]
synonym: "dihydrocoumarin lipase activity" EXACT []
xref: EC:3.1.1.35
xref: KEGG_REACTION:R03692
xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN
xref: RHEA:10360
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047857
name: dihydrouracil oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + O2 = H2O2 + uracil." [EC:1.3.3.7, RHEA:12384]
synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" RELATED [EC:1.3.3.7]
xref: EC:1.3.3.7
xref: KEGG_REACTION:R00975
xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN
xref: RHEA:12384
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0047858
name: dihydroxyfumarate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroxyfumarate + H+ = 2-hydroxy-3-oxopropanoate + CO2." [EC:4.1.1.54, RHEA:13845]
synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" RELATED [EC:4.1.1.54]
synonym: "dihydroxyfumarate carboxy-lyase activity" RELATED [EC:4.1.1.54]
xref: EC:4.1.1.54
xref: KEGG_REACTION:R03127
xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN
xref: RHEA:13845
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047859
name: obsolete dihydroxyphenylalanine ammonia-lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3." [EC:4.3.1.11, MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN]
comment: This term was made obsolete because the corresponding EC reaction (EC:4.3.1.11) has been deleted from the EC.
synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)" RELATED [EC:4.3.1.11]
synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase activity" RELATED [EC:4.3.1.11]
synonym: "beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity" RELATED [EC:4.3.1.11]
synonym: "dihydroxyphenylalanine ammonia-lyase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0047860
name: diiodophenylpyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH." [EC:1.1.1.96, RHEA:20293]
synonym: "2-oxo acid reductase activity" RELATED [EC:1.1.1.96]
synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.96]
synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96]
synonym: "KAR" RELATED [EC:1.1.1.96]
xref: EC:1.1.1.96
xref: KEGG_REACTION:R03431
xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN
xref: RHEA:20293
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047861
name: diiodotyrosine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate." [EC:2.6.1.24, RHEA:19781]
synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.24]
synonym: "diiodotyrosine aminotransferase activity" EXACT []
synonym: "halogenated tyrosine aminotransferase activity" RELATED [EC:2.6.1.24]
synonym: "halogenated tyrosine transaminase activity" RELATED [EC:2.6.1.24]
xref: EC:2.6.1.24
xref: KEGG_REACTION:R03207
xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN
xref: RHEA:19781
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047862
name: diisopropyl-fluorophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H+." [RHEA:24100]
synonym: "DFPase activity" RELATED [EC:3.8.2.2]
synonym: "dialkylfluorophosphatase activity" RELATED [EC:3.8.2.2]
synonym: "diisopropyl phosphorofluoridate hydrolase activity" RELATED [EC:3.8.2.2]
synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" RELATED [EC:3.8.2.2]
synonym: "diisopropylfluorophosphonate dehalogenase activity" RELATED [EC:3.8.2.2]
synonym: "diisopropylphosphofluoridase activity" RELATED [EC:3.8.2.2]
synonym: "isopropylphosphorofluoridase activity" RELATED [EC:3.8.2.2]
synonym: "OPA anhydrase activity" RELATED [EC:3.8.2.2]
synonym: "OPAA activity" RELATED [EC:3.8.2.2]
synonym: "organophosphate acid anhydrase activity" RELATED [EC:3.8.2.2]
synonym: "organophosphorus acid anhydrolase activity" RELATED [EC:3.8.2.2]
synonym: "somanase activity" RELATED [EC:3.8.2.2]
synonym: "tabunase activity" RELATED [EC:3.8.2.2]
xref: EC:3.8.2.2
xref: KEGG_REACTION:R01533
xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN
xref: RHEA:24100
is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds

[Term]
id: GO:0047863
name: dimethylallylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, RHEA:11328]
synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" RELATED [EC:2.5.1.28]
synonym: "neryl-diphosphate synthase activity" RELATED [EC:2.5.1.28]
xref: EC:2.5.1.28
xref: KEGG_REACTION:R01659
xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN
xref: RHEA:11328
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0047864
name: dimethylaniline-N-oxide aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, RHEA:19321]
synonym: "microsomal N-oxide dealkylase activity" RELATED [EC:4.1.2.24]
synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24]
synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" RELATED [EC:4.1.2.24]
synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" RELATED [EC:4.1.2.24]
xref: EC:4.1.2.24
xref: KEGG_REACTION:R03345
xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN
xref: RHEA:19321
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047865
name: dimethylglycine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.4, RHEA:52856]
comment: Note that this was EC:1.5.99.2.
synonym: "N,N-dimethylglycine oxidase activity" RELATED [EC:1.5.8.4]
synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" RELATED [EC:1.5.8.4]
synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" RELATED [EC:1.5.8.4]
xref: EC:1.5.8.4
xref: KEGG_REACTION:R01565
xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-6797653 "DMGDH:FAD oxidatively demethylates DMGLY to SARC"
xref: RHEA:52856
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0047866
name: dimethylglycine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine." [EC:1.5.3.10, RHEA:17077]
synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.10]
xref: EC:1.5.3.10
xref: KEGG_REACTION:R01564
xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN
xref: RHEA:17077
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0047867
name: dimethylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH." [EC:1.1.1.84, RHEA:13321]
synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.84]
synonym: "beta,beta-dimethylmalate dehydrogenase activity" RELATED [EC:1.1.1.84]
xref: EC:1.1.1.84
xref: KEGG_REACTION:R01211
xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN
xref: RHEA:13321
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047868
name: dimethylmaleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O." [EC:4.2.1.85, RHEA:20253]
synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" RELATED [EC:4.2.1.85]
synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" RELATED [EC:4.2.1.85]
xref: EC:4.2.1.85
xref: KEGG_REACTION:R03069
xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN
xref: RHEA:20253
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047869
name: dimethylpropiothetin dethiomethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H+." [EC:4.4.1.3, RHEA:19965]
synonym: "desulfhydrase activity" RELATED [EC:4.4.1.3]
synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" RELATED [EC:4.4.1.3]
synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" RELATED [EC:4.4.1.3]
xref: EC:4.4.1.3
xref: KEGG_REACTION:R02574
xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN
xref: RHEA:19965
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047870
name: discadenine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H+." [EC:2.5.1.24, RHEA:19581]
synonym: "discadenine synthetase activity" RELATED [EC:2.5.1.24]
synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" RELATED [EC:2.5.1.24]
synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24]
xref: EC:2.5.1.24
xref: KEGG_REACTION:R03726
xref: MetaCyc:DISCADENINE-SYNTHASE-RXN
xref: RHEA:19581
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047871
name: disulfoglucosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + H+ + sulfate." [EC:3.1.6.11, RHEA:15517]
synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" RELATED [EC:3.1.6.11]
synonym: "disulphoglucosamine-6-sulphatase activity" EXACT []
synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" RELATED [EC:3.1.6.11]
synonym: "N-sulfoglucosamine-6-sulfatase activity" RELATED [EC:3.1.6.11]
xref: EC:3.1.6.11
xref: KEGG_REACTION:R03216
xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN
xref: RHEA:15517
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047872
name: dolichol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:dolichol acyltransferase activity" RELATED [EC:2.3.1.123]
synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" RELATED [EC:2.3.1.123]
xref: EC:2.3.1.123
xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN
xref: RHEA:16685
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047873
name: dolichyl-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN]
synonym: "Dol-P phosphatase activity" RELATED [EC:3.1.3.51]
synonym: "Dol-P-P phosphohydrolase activity" EXACT []
synonym: "dolichol monophosphatase activity" RELATED [EC:3.1.3.51]
synonym: "dolichol phosphatase activity" RELATED [EC:3.1.3.51]
synonym: "dolichol phosphate phosphatase activity" RELATED [EC:3.1.3.51]
synonym: "dolichyl monophosphate phosphatase activity" RELATED [EC:3.1.3.51]
synonym: "dolichyl phosphate phosphatase activity" RELATED [EC:3.1.3.51]
synonym: "dolichyl pyrophosphate phosphatase activity" EXACT []
synonym: "dolichyl-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.51]
synonym: "polyisoprenyl phosphate phosphatase activity" RELATED [EC:3.1.3.51]
synonym: "polyprenylphosphate phosphatase activity" RELATED [EC:3.1.3.51]
xref: EC:3.1.3.51
xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN
xref: RHEA:13797
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047874
name: dolichyldiphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN]
synonym: "dolichol diphosphatase activity" RELATED [EC:3.6.1.43]
synonym: "dolichyl diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.43]
synonym: "dolichyl pyrophosphatase activity" RELATED [EC:3.6.1.43]
synonym: "dolichyl-diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.43]
xref: EC:3.6.1.43
xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN
xref: Reactome:R-HSA-446200 "DOLPP1 dephosphorylates DOLDP to DOLP"
xref: RHEA:14385
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047875
name: ecdysone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: Ecdysone + O2 = 3-dehydroecdysone + H2O2." [EC:1.1.3.16, RHEA:11796]
synonym: "beta-ecdysone oxidase activity" RELATED [EC:1.1.3.16]
synonym: "ecdysone:oxygen 3-oxidoreductase activity" RELATED [EC:1.1.3.16]
xref: EC:1.1.3.16
xref: KEGG_REACTION:R02373
xref: MetaCyc:ECDYSONE-OXIDASE-RXN
xref: RHEA:11796
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047876
name: endoglycosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN]
synonym: "EGCase activity" RELATED [EC:3.2.1.123]
synonym: "endo-glucosylceramidase activity" RELATED [EC:3.2.1.123]
synonym: "endoglycoceramidase activity" RELATED [EC:3.2.1.123]
synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" RELATED [EC:3.2.1.123]
synonym: "oligoglycosylglucosylceramide glycohydrolase activity" RELATED [EC:3.2.1.123]
xref: EC:3.2.1.123
xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN
xref: RHEA:22288
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047877
name: ephedrine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,2S)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H+ + NADH." [EC:1.5.1.18, RHEA:16289]
synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" RELATED [EC:1.5.1.18]
xref: EC:1.5.1.18
xref: KEGG_REACTION:R03614
xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN
xref: RHEA:16289
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047878
name: erythritol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H+." [EC:2.7.1.27, RHEA:20708]
synonym: "ATP:erythritol 4-phosphotransferase activity" RELATED [EC:2.7.1.27]
synonym: "erythritol kinase (phosphorylating)" RELATED [EC:2.7.1.27]
xref: EC:2.7.1.27
xref: KEGG_REACTION:R02430
xref: MetaCyc:ERYTHRITOL-KINASE-RXN
xref: RHEA:20708
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047879
name: erythronolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN]
synonym: "erythronolide condensing enzyme activity" RELATED [EC:2.3.1.94]
synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" RELATED [EC:2.3.1.94]
xref: EC:2.3.1.94
xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN
xref: RHEA:23068
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047880
name: erythrulose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-threitol + NADP+ = D-erythrulose + H+ + NADPH." [EC:1.1.1.162, RHEA:18005]
synonym: "D-erythrulose reductase activity" RELATED [EC:1.1.1.162]
synonym: "erythritol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.162]
xref: EC:1.1.1.162
xref: KEGG_REACTION:R08573
xref: MetaCyc:RXN-17773
xref: RHEA:18005
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047881
name: estradiol 17-alpha-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148]
synonym: "17alpha-estradiol dehydrogenase activity" RELATED [EC:1.1.1.148]
synonym: "17alpha-hydroxy steroid dehydrogenase activity" RELATED [EC:1.1.1.148]
synonym: "17alpha-hydroxy steroid oxidoreductase activity" RELATED [EC:1.1.1.148]
synonym: "17alpha-hydroxysteroid oxidoreductase activity" RELATED [EC:1.1.1.148]
synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" RELATED [EC:1.1.1.148]
synonym: "estradiol 17a-dehydrogenase activity" EXACT []
synonym: "estradiol 17alpha-dehydrogenase activity" RELATED [EC:1.1.1.148]
synonym: "estradiol 17alpha-oxidoreductase activity" RELATED [EC:1.1.1.148]
xref: EC:1.1.1.148
xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047882
name: estradiol 6-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + estradiol-17beta + O2 = 6beta-hydroxyestradiol-17beta + A + H2O." [EC:1.14.99.11, RHEA:19137]
synonym: "estradiol 6-beta-hydroxylase activity" RELATED [EC:1.14.99.11]
synonym: "estradiol 6b-hydroxylase activity" EXACT []
synonym: "estradiol 6b-monooxygenase activity" EXACT []
synonym: "estradiol 6beta-hydroxylase activity" RELATED [EC:1.14.99.11]
synonym: "estradiol 6beta-monooxygenase activity" RELATED [EC:1.14.99.11]
synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" RELATED [EC:1.14.99.11]
xref: EC:1.14.99.11
xref: KEGG_REACTION:R03086
xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN
xref: RHEA:19137
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047883
name: ethanolamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [RHEA:18581]
synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.8]
xref: EC:1.4.3.8
xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN
xref: RHEA:18581
is_a: GO:0052595 ! aliphatic amine oxidase activity

[Term]
id: GO:0047884
name: FAD diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [RHEA:13889]
synonym: "FAD nucleotidohydrolase activity" RELATED [EC:3.6.1.18]
synonym: "FAD pyrophosphatase activity" EXACT []
synonym: "FAD pyrophosphohydrolase activity" EXACT [GOC:tb]
synonym: "flavin adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18]
synonym: "flavine adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18]
synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18]
synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18]
xref: EC:3.6.1.18
xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN
xref: RHEA:13889
is_a: GO:0004551 ! dinucleotide phosphatase activity

[Term]
id: GO:0047885
name: farnesol 2-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, RHEA:13401]
synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" RELATED [EC:5.2.1.9]
synonym: "farnesol isomerase activity" RELATED [EC:5.2.1.9]
xref: EC:5.2.1.9
xref: KEGG_REACTION:R03265
xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN
xref: RHEA:13401
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047886
name: farnesol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + H+ + NADPH." [EC:1.1.1.216, RHEA:14697]
synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.216]
synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.216]
synonym: "NADP-farnesol dehydrogenase activity" RELATED [EC:1.1.1.216]
xref: EC:1.1.1.216
xref: KEGG_REACTION:R03264
xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN
xref: RHEA:14697
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047887
name: farnesyl diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP." [RHEA:21544]
synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.18]
synonym: "farnesyl pyrophosphate kinase activity" RELATED [EC:2.7.4.18]
synonym: "farnesyl-diphosphate kinase activity" EXACT []
xref: EC:2.7.4.18
xref: KEGG_REACTION:R02303
xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN
xref: RHEA:21544
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047888
name: fatty acid peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O2 + H+ + palmitate = CO2 + 3 H2O + pentadecanal." [EC:1.11.1.3, RHEA:23960]
synonym: "fatty-acid peroxidase activity" EXACT []
synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.3]
synonym: "long chain fatty acid peroxidase activity" RELATED [EC:1.11.1.3]
xref: EC:1.11.1.3
xref: KEGG_REACTION:R01703
xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN
xref: RHEA:23960
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0047889
name: ferredoxin-nitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin." [RHEA:21828]
synonym: "assimilatory ferredoxin-nitrate reductase activity" RELATED [EC:1.7.7.2]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2]
synonym: "nitrate (ferredoxin) reductase activity" RELATED [EC:1.7.7.2]
synonym: "nitrite:ferredoxin oxidoreductase activity" RELATED [EC:1.7.7.2]
xref: EC:1.7.7.2
xref: MetaCyc:1.7.7.2-RXN
xref: RHEA:21828
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047890
name: flavanone 4-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN]
synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.234]
synonym: "flavonone 4-reductase activity" EXACT []
xref: EC:1.1.1.234
xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN
xref: RHEA:11228
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047891
name: flavone 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" RELATED [EC:2.4.1.81]
synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81]
synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81]
synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" RELATED [EC:2.4.1.81]
synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81]
synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81]
synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.81]
synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" RELATED [EC:2.4.1.81]
xref: EC:2.4.1.81
xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:19577
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047892
name: flavone apiosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN]
synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" RELATED [EC:2.4.2.25]
synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" RELATED [EC:2.4.2.25]
synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" RELATED [EC:2.4.2.25]
xref: EC:2.4.2.25
xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN
xref: RHEA:19153
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0047893
name: flavonol 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN]
synonym: "GTI" RELATED [EC:2.4.1.91]
synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91]
synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.91]
synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91]
synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91]
synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.91]
synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91]
xref: EC:2.4.1.91
xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:22300
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047894
name: flavonol 3-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate." [EC:2.8.2.25, RHEA:13453]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT systematic_synonym [EC:2.8.2.25]
synonym: "flavonol 3-sulphotransferase activity" EXACT []
xref: EC:2.8.2.25
xref: KEGG_REACTION:R02159
xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN
xref: RHEA:13453
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047895
name: formaldehyde dismutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.98.1]
synonym: "aldehyde dismutase activity" RELATED [EC:1.2.98.1]
synonym: "cannizzanase activity" RELATED [EC:1.2.98.1]
synonym: "formaldehyde:formaldehyde oxidoreductase activity" RELATED [EC:1.2.98.1]
synonym: "nicotinoprotein aldehyde dismutase" RELATED [EC:1.2.98.1]
xref: EC:1.2.98.1
xref: MetaCyc:RXN-11453
xref: RHEA:19221
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047896
name: formaldehyde transketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN]
synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" RELATED [EC:2.2.1.3]
synonym: "DHAS activity" RELATED [EC:2.2.1.3]
synonym: "dihydroxyacetone synthase activity" RELATED [EC:2.2.1.3]
synonym: "glycerone synthase activity" RELATED [EC:2.2.1.3]
xref: EC:2.2.1.3
xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN
xref: RHEA:24264
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0047897
name: formate-dihydrofolate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H+ + phosphate." [EC:6.3.4.17, RHEA:24328]
synonym: "dihydrofolate formyltransferase activity" RELATED [EC:6.3.4.17]
synonym: "formate:dihydrofolate ligase (ADP-forming)" RELATED [EC:6.3.4.17]
synonym: "formyl dihydrofolate synthase activity" RELATED [EC:6.3.4.17]
xref: EC:6.3.4.17
xref: KEGG_REACTION:R02238
xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN
xref: RHEA:24328
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047898
name: formate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "formate:cytochrome b1 oxidoreductase activity" RELATED [EC:1.2.2.1]
synonym: "formate:ferricytochrome-b1 oxidoreductase activity" RELATED [EC:1.2.2.1]
xref: EC:1.2.2.1
xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN
xref: RHEA:21520
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0047899
name: formate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + NADP+ = CO2 + NADPH." [EC:1.17.1.10, RHEA:12000]
synonym: "formate:NADP+ oxidoreductase activity" RELATED [EC:1.17.1.10]
synonym: "NADP-dependent formate dehydrogenase activity" RELATED [EC:1.17.1.10]
xref: EC:1.17.1.10
xref: KEGG_REACTION:R00134
xref: MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:12000
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047900
name: formate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H+." [EC:2.7.2.6, RHEA:16009]
synonym: "ATP:formate phosphotransferase activity" RELATED [EC:2.7.2.6]
xref: EC:2.7.2.6
xref: KEGG_REACTION:R00518
xref: MetaCyc:FORMATE-KINASE-RXN
xref: RHEA:16009
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047901
name: obsolete formyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: formyl-CoA + H2O = CoA + formate + H+." [GOC:curators]
comment: This term was obsoleted because the enzyme that catalyzes this reaction has not been identified.
synonym: "formyl coenzyme A hydrolase activity" RELATED []
is_obsolete: true
replaced_by: GO:0016289

[Term]
id: GO:0047902
name: formylaspartate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN]
synonym: "formylaspartic formylase (formylase I, formylase II)" RELATED [EC:3.5.1.8]
synonym: "N-formyl-L-aspartate amidohydrolase activity" RELATED [EC:3.5.1.8]
xref: EC:3.5.1.8
xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN
xref: RHEA:22040
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047903
name: fructose 5-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN]
synonym: "5-keto-D-fructose reductase (NADP+)" RELATED [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP(+)) activity" RELATED [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP)" RELATED [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP+) activity" RELATED [EC:1.1.1.124]
synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" RELATED [EC:1.1.1.124]
synonym: "D-fructose:NADP+ 5-oxidoreductase activity" RELATED [EC:1.1.1.124]
synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.124]
xref: EC:1.1.1.124
xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN
xref: RHEA:14069
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047904
name: fructose 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a ubiquinone + keto-D-fructose = 5-dehydro-D-fructose + a ubiquinol." [RHEA:22304]
synonym: "D-fructose dehydrogenase activity" RELATED [EC:1.1.5.14]
xref: EC:1.1.5.14
xref: KEGG_REACTION:R00873
xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN
xref: RHEA:22304
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0047905
name: fructose-6-phosphate phosphoketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN]
synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" RELATED [EC:4.1.2.22]
synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" RELATED [EC:4.1.2.22]
xref: EC:4.1.2.22
xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN
xref: RHEA:12196
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047906
name: fucosterol-epoxide lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol." [EC:4.1.2.33, RHEA:10884]
synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" RELATED [EC:4.1.2.33]
synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" RELATED [EC:4.1.2.33]
xref: EC:4.1.2.33
xref: KEGG_REACTION:R03723
xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN
xref: RHEA:10884
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047907
name: furylfuramide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, RHEA:21848]
synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" RELATED [EC:5.2.1.6]
xref: EC:5.2.1.6
xref: KEGG_REACTION:R04538
xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN
xref: RHEA:21848
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047908
name: fusarinine-C ornithinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN]
synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" RELATED [EC:3.1.1.48]
synonym: "N5-acyl-L-ornithine-ester hydrolase activity" RELATED [EC:3.1.1.48]
synonym: "ornithine esterase activity" RELATED [EC:3.1.1.48]
xref: EC:3.1.1.48
xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN
xref: RHEA:20165
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047909
name: galactolipid O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN]
synonym: "galactolipid:galactolipid acyltransferase activity" RELATED [EC:2.3.1.134]
synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" RELATED [EC:2.3.1.134]
xref: EC:2.3.1.134
xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047910
name: galactose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN]
synonym: "D-galactose dehydrogenase (NADP+)" RELATED [EC:1.1.1.120]
synonym: "D-galactose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.120]
xref: EC:1.1.1.120
xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:18625
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047911
name: galacturan 1,4-alpha-galacturonidase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN]
synonym: "exo-D-galacturonanase activity" RELATED [EC:3.2.1.67]
synonym: "exo-D-galacturonase activity" EXACT []
synonym: "exo-polygalacturonase activity" EXACT []
synonym: "exopoly-D-galacturonase activity" EXACT []
synonym: "exopolygalacturonase activity" RELATED [EC:3.2.1.67]
synonym: "galacturan alpha-1,4-galacturonidase activity" EXACT []
synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" RELATED [EC:3.2.1.67]
synonym: "poly(galacturonate) hydrolase activity" RELATED [EC:3.2.1.67]
xref: EC:3.2.1.67
xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN
xref: RHEA:14117
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047912
name: galacturonokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H+." [EC:2.7.1.44, RHEA:12965]
synonym: "ATP:D-galacturonate 1-phosphotransferase activity" RELATED [EC:2.7.1.44]
synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" RELATED [EC:2.7.1.44]
xref: EC:2.7.1.44
xref: KEGG_REACTION:R01980
xref: MetaCyc:GALACTURONOKINASE-RXN
xref: RHEA:12965
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047913
name: gallate 1-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP." [EC:2.4.1.136, RHEA:15249]
synonym: "gallate 1-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" RELATED [EC:2.4.1.136]
synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.136]
synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" RELATED [EC:2.4.1.136]
synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.136]
synonym: "UDPglucose:gallate glucosyltransferase activity" RELATED [EC:2.4.1.136]
synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" RELATED [EC:2.4.1.136]
xref: EC:2.4.1.136
xref: KEGG_REACTION:R03297
xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:15249
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047914
name: gamma-glutamylhistamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN]
synonym: "g-glutamylhistamine synthase activity" EXACT []
synonym: "gamma-GHA synthetase activity" RELATED [EC:6.3.2.18]
synonym: "gamma-glutaminylhistamine synthetase activity" RELATED [EC:6.3.2.18]
synonym: "L-glutamate:histamine ligase activity" RELATED [EC:6.3.2.18]
xref: EC:6.3.2.18
xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN
xref: RHEA:18881
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047915
name: ganglioside galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN]
synonym: "GM1-synthase activity" RELATED [EC:2.4.1.62]
synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "UDP-galactose-GM2 galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "UDPgalactose-ceramide galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" RELATED [EC:2.4.1.62]
synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" RELATED [EC:2.4.1.62]
xref: EC:2.4.1.62
xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN
xref: RHEA:16773
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047916
name: GDP-6-deoxy-D-talose 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN]
synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" RELATED [EC:1.1.1.135]
synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" RELATED [EC:1.1.1.135]
xref: EC:1.1.1.135
xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047917
name: GDP-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + H2O = D-glucose + GDP + H+." [EC:3.2.1.42, RHEA:15049]
synonym: "GDP-glucose glucohydrolase activity" RELATED [EC:3.2.1.42]
synonym: "GDPglucose glucohydrolase activity" RELATED [EC:3.2.1.42]
synonym: "GDPglucosidase activity" RELATED [EC:3.2.1.42]
synonym: "guanosine diphosphate D-glucose glucohydrolase activity" RELATED [EC:3.2.1.42]
synonym: "guanosine diphosphoglucosidase activity" RELATED [EC:3.2.1.42]
xref: EC:3.2.1.42
xref: KEGG_REACTION:R00337
xref: MetaCyc:GDP-GLUCOSIDASE-RXN
xref: RHEA:15049
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0047918
name: GDP-mannose 3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [PMID:16366586, PMID:8910301]
synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" RELATED [EC:5.1.3.18]
synonym: "GDPmannose 3,5-epimerase activity" RELATED [EC:5.1.3.18]
synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" RELATED [EC:5.1.3.18]
xref: EC:5.1.3.18
xref: MetaCyc:RXN-7772
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047919
name: GDP-mannose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O + 2 NAD+ = GDP-D-mannuronate + 3 H+ + 2 NADH." [EC:1.1.1.132, RHEA:21728]
synonym: "GDP mannose dehydrogenase activity" RELATED [EC:1.1.1.132]
synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" RELATED [EC:1.1.1.132]
synonym: "GDPmannose 6-dehydrogenase activity" RELATED [EC:1.1.1.132]
synonym: "guanosine diphospho-D-mannose dehydrogenase activity" RELATED [EC:1.1.1.132]
synonym: "guanosine diphosphomannose dehydrogenase activity" RELATED [EC:1.1.1.132]
xref: EC:1.1.1.132
xref: KEGG_REACTION:R00880
xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN
xref: RHEA:21728
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047920
name: geissoschizine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + H+ + NADPH." [EC:1.3.1.36, RHEA:11376]
synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" RELATED [EC:1.3.1.36]
xref: EC:1.3.1.36
xref: KEGG_REACTION:R03860
xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN
xref: RHEA:11376
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047921
name: aminoglycoside 2'-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H+. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.59, RHEA:24516]
synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59]
synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59]
synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW []
synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59]
synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW []
synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59]
xref: EC:2.3.1.59
xref: KEGG_REACTION:R03056
xref: MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN
xref: RHEA:24516
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0047922
name: gentisate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+." [EC:1.13.11.4, RHEA:18237]
synonym: "2,5-dihydroxybenzoate dioxygenase activity" RELATED [EC:1.13.11.4]
synonym: "gentisate dioxygenase activity" RELATED [EC:1.13.11.4]
synonym: "gentisate oxygenase activity" RELATED [EC:1.13.11.4]
synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.4]
synonym: "gentisic acid oxidase activity" RELATED [EC:1.13.11.4]
xref: EC:1.13.11.4
xref: KEGG_REACTION:R02656
xref: MetaCyc:GENTISATE-12-DIOXYGENASE-RXN
xref: RHEA:18237
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047923
name: gentisate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + H+ = CO2 + hydroquinone." [EC:4.1.1.62, RHEA:21312]
synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" RELATED [EC:4.1.1.62]
synonym: "2,5-dihydroxybenzoate decarboxylase activity" RELATED [EC:4.1.1.62]
synonym: "gentisate carboxy-lyase activity" RELATED [EC:4.1.1.62]
xref: EC:4.1.1.62
xref: KEGG_REACTION:R02489
xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN
xref: RHEA:21312
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047924
name: geraniol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN]
synonym: "geraniol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.183]
xref: EC:1.1.1.183
xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN
xref: RHEA:14521
xref: UM-BBD_reactionID:r1163
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047925
name: geranoyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate." [EC:6.4.1.5, RHEA:17701]
synonym: "geranoyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.5]
synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.5]
synonym: "geranyl-CoA carboxylase activity" RELATED [EC:6.4.1.5]
xref: EC:6.4.1.5
xref: KEGG_REACTION:R03494
xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN
xref: RHEA:17701
xref: UM-BBD_reactionID:r1166
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0047926
name: geranyl-diphosphate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate." [PMID:42357, RHEA:18209]
synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" RELATED [EC:5.5.1.8]
synonym: "(+)-bornylpyrophosphate cyclase activity" RELATED [EC:5.5.1.8]
synonym: "bornyl diphosphate synthase activity" RELATED [EC:5.5.1.8]
synonym: "bornyl pyrophosphate synthase activity" RELATED [EC:5.5.1.8]
synonym: "bornyl pyrophosphate synthetase activity" RELATED [EC:5.5.1.8]
xref: EC:5.5.1.8
xref: KEGG_REACTION:R02007
xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN
xref: RHEA:18209
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047927
name: obsolete gibberellin-44 dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [PMID:32652020]
comment: This term was obsoleted because it is an intermediate in gibberellin 20-oxidase activity GO:0045544, see PMID:32652020.
is_obsolete: true
replaced_by: GO:0045544

[Term]
id: GO:0047928
name: gibberellin beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "gibberellin b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.176]
synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.176]
synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.176]
synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" RELATED [EC:2.4.1.176]
xref: EC:2.4.1.176
xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:20025
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047929
name: gluconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.39, RHEA:21612]
synonym: "D-gluconate dehydratase activity" RELATED [EC:4.2.1.39]
synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" RELATED [EC:4.2.1.39]
synonym: "D-gluconate hydro-lyase activity" RELATED [EC:4.2.1.39]
xref: EC:4.2.1.39
xref: KEGG_REACTION:R01538
xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN
xref: RHEA:21612
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047930
name: glucosaminate ammonia-lyase activity
namespace: molecular_function
alt_id: GO:0050443
def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9]
comment: Note that this function was EC:4.3.1.21.
synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" RELATED [EC:4.3.1.9]
synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.9]
synonym: "acetylenemonocarboxylic acid hydrase activity" RELATED [EC:4.3.1.9]
synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT []
synonym: "aminodeoxygluconate dehydratase activity" EXACT []
synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" RELATED [EC:4.3.1.9]
synonym: "D-glucosaminate ammonia-lyase activity" RELATED [EC:4.3.1.9]
synonym: "D-glucosaminate dehydratase activity" RELATED [EC:4.3.1.9]
synonym: "D-glucosaminic acid dehydrase activity" RELATED [EC:4.3.1.9]
synonym: "glucosaminic dehydrase activity" RELATED [EC:4.3.1.9]
xref: EC:4.3.1.9
xref: MetaCyc:4.3.1.21-RXN
xref: RHEA:12488
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047931
name: glucosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H+." [RHEA:10948]
synonym: "aminodeoxyglucose kinase activity" RELATED [EC:2.7.1.8]
synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" RELATED [EC:2.7.1.8]
synonym: "ATP:D-glucosamine phosphotransferase activity" RELATED [EC:2.7.1.8]
synonym: "glucosamine kinase (phosphorylating)" RELATED [EC:2.7.1.8]
xref: EC:2.7.1.8
xref: MetaCyc:GLUCOSAMINE-KINASE-RXN
xref: RHEA:10948
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047932
name: glucosamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H+." [EC:2.3.1.3, RHEA:21332]
synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" RELATED [EC:2.3.1.3]
synonym: "glucosamine acetylase activity" RELATED [EC:2.3.1.3]
synonym: "glucosamine acetyltransferase activity" RELATED [EC:2.3.1.3]
xref: EC:2.3.1.3
xref: KEGG_REACTION:R01204
xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:21332
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047933
name: glucose-1,6-bisphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+." [EC:2.7.1.106, RHEA:16769]
synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.106]
synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.106]
synonym: "glucose 1,6-diphosphate synthase activity" RELATED [EC:2.7.1.106]
synonym: "glucose-1,6-bisphosphate synthetase activity" RELATED [EC:2.7.1.106]
xref: EC:2.7.1.106
xref: KEGG_REACTION:R01660
xref: MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN
xref: Reactome:R-HSA-8955760 "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP"
xref: RHEA:16769
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047934
name: glucose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN]
synonym: "D-aldohexose dehydrogenase activity" RELATED [EC:1.1.1.118]
synonym: "D-glucose:NAD oxidoreductase activity" RELATED [EC:1.1.1.118]
synonym: "D-glucose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.118]
xref: EC:1.1.1.118
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN
xref: RHEA:14293
is_a: GO:0047936 ! glucose 1-dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0047935
name: glucose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN]
synonym: "D-glucose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.119]
synonym: "NADP-dependent glucose dehydrogenase activity" RELATED [EC:1.1.1.119]
synonym: "NADP-linked aldohexose dehydrogenase activity" RELATED [EC:1.1.1.119]
synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" RELATED [EC:1.1.1.119]
xref: EC:1.1.1.119
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:14405
is_a: GO:0047936 ! glucose 1-dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0047936
name: glucose 1-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47]
comment: This enzyme has similar activity with either NAD+ or NADP+.
synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" RELATED [EC:1.1.1.47]
synonym: "D-glucose dehydrogenase (NAD(P))" RELATED [EC:1.1.1.47]
synonym: "hexose phosphate dehydrogenase activity" RELATED [EC:1.1.1.47]
xref: EC:1.1.1.47
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN
is_a: GO:0004344 ! glucose dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047937
name: glucose-1-phosphate phosphodismutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN]
synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.41]
synonym: "glucose 1-phosphate transphosphorylase activity" RELATED [EC:2.7.1.41]
synonym: "phosphodismutase activity" RELATED [EC:2.7.1.41]
xref: EC:2.7.1.41
xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN
xref: RHEA:16397
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047938
name: glucose-6-phosphate 1-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN]
synonym: "D-glucose-6-phosphate 1-epimerase activity" RELATED [EC:5.1.3.15]
synonym: "glucose-6 phosphate 1-epimerase activity" EXACT []
xref: EC:5.1.3.15
xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN
xref: RHEA:16249
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047939
name: L-glucuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH." [EC:1.1.1.19, RHEA:14909]
synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19]
synonym: "D-glucuronate dehydrogenase activity" RELATED [EC:1.1.1.19]
synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19]
synonym: "glucuronate dehydrogenase activity" RELATED [EC:1.1.1.19]
synonym: "glucuronate reductase activity" EXACT []
synonym: "NADP-L-gulonate dehydrogenase activity" RELATED [EC:1.1.1.19]
synonym: "TPN-L-gulonate dehydrogenase activity" RELATED [EC:1.1.1.19]
xref: EC:1.1.1.19
xref: KEGG_REACTION:R01481
xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN
xref: Reactome:R-HSA-5661256 "AKR1A1 reduces D-glucuronate to L-gulonate"
xref: RHEA:14909
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047940
name: glucuronokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H+." [EC:2.7.1.43, RHEA:17005]
synonym: "ATP:D-glucuronate 1-phosphotransferase activity" RELATED [EC:2.7.1.43]
synonym: "glucurono-glucuronokinase activity" RELATED [EC:2.7.1.43]
synonym: "glucuronokinase (phosphorylating)" RELATED [EC:2.7.1.43]
xref: EC:2.7.1.43
xref: KEGG_REACTION:R01476
xref: MetaCyc:GLUCURONOKINASE-RXN
xref: RHEA:17005
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047941
name: glucuronolactone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH." [EC:1.1.1.20, RHEA:18925]
xref: EC:1.1.1.20
xref: KEGG_REACTION:R03183
xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN
xref: RHEA:18925
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047942
name: glutamate-ethylamine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H+ + phosphate." [EC:6.3.1.6, RHEA:20525]
synonym: "L-glutamate:ethylamine ligase (ADP-forming)" RELATED [EC:6.3.1.6]
synonym: "N(5)-ethyl-L-glutamine synthetase activity" RELATED [EC:6.3.1.6]
synonym: "N5-ethyl-L-glutamine synthetase activity" RELATED [EC:6.3.1.6]
synonym: "N5-ethylglutamine synthetase activity" RELATED [EC:6.3.1.6]
synonym: "theanine synthetase activity" RELATED [EC:6.3.1.6]
xref: EC:6.3.1.6
xref: KEGG_REACTION:R02929
xref: MetaCyc:RXN-12905
xref: RHEA:20525
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047943
name: glutamate-methylamine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H+ + phosphate." [EC:6.3.4.12, RHEA:17117]
synonym: "gamma-glutamylmethylamide synthetase activity" RELATED [EC:6.3.4.12]
synonym: "L-glutamate:methylamine ligase (ADP-forming)" RELATED [EC:6.3.4.12]
xref: EC:6.3.4.12
xref: KEGG_REACTION:R01585
xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN
xref: RHEA:17117
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047944
name: obsolete glutamate 1-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-glutamate + ATP = alpha-L-glutamyl phosphate + ADP + H+." [GOC:curators]
comment: This term is slated for obsoletion. RHEA indicates the activity has been shown not to exist.
synonym: "ATP:L-glutamate 1-phosphotransferase activity" RELATED []
is_obsolete: true

[Term]
id: GO:0047945
name: L-glutamine:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, RHEA:10400]
synonym: "gamma-glutaminyltransferase activity" RELATED [EC:2.6.1.15]
synonym: "glutaminase II activity" RELATED [EC:2.6.1.15]
synonym: "glutamine transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine transaminase L activity" BROAD [EC:2.6.1.15]
synonym: "glutamine--oxo-acid transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine--pyruvate aminotransferase activity" BROAD []
synonym: "glutamine-alpha-keto acid transamidase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-alpha-keto acid transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-keto acid aminotransferase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-oxo acid aminotransferase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-pyruvate transaminase activity" BROAD [EC:2.6.1.15]
synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15]
xref: EC:2.6.1.15
xref: KEGG_REACTION:R00576
xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-893616 "glutamine + pyruvate => 2-oxoglutaramate + alanine"
xref: RHEA:10400
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0047946
name: glutamine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" RELATED [EC:2.3.1.68]
xref: EC:2.3.1.68
xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN
xref: RHEA:18469
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0047947
name: glutamine N-phenylacetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN]
synonym: "glutamine phenylacetyltransferase activity" RELATED [EC:2.3.1.14]
synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" RELATED [EC:2.3.1.14]
synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" RELATED [EC:2.3.1.14]
xref: EC:2.3.1.14
xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN
xref: RHEA:21844
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047948
name: glutarate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H+ + phosphate." [EC:6.2.1.6, RHEA:14169]
synonym: "glutarate:CoA ligase (ADP-forming)" RELATED [EC:6.2.1.6]
synonym: "glutaryl coenzyme A synthetase activity" RELATED [EC:6.2.1.6]
synonym: "glutaryl-CoA synthetase activity" RELATED [EC:6.2.1.6]
xref: EC:6.2.1.6
xref: KEGG_REACTION:R02402
xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN
xref: RHEA:14169
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047949
name: obsolete glutarate-semialdehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [GOC:curators]
comment: This term was obsoleted because there is no evidence that this reaction is physiological.
synonym: "glutarate semialdehyde dehydrogenase (NAD+) activity" EXACT []
is_obsolete: true
replaced_by: GO:0102810

[Term]
id: GO:0047950
name: glutathione oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2." [EC:1.8.3.3, RHEA:24112]
synonym: "glutathione:oxygen oxidoreductase activity" RELATED [EC:1.8.3.3]
xref: EC:1.8.3.3
xref: KEGG_REACTION:R00120
xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN
xref: RHEA:24112
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0047951
name: glutathione thiolesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-acylglutathione + H2O = a carboxylate + glutathione + H+." [EC:3.1.2.7, RHEA:22708]
synonym: "citryl-glutathione thioesterhydrolase activity" RELATED [EC:3.1.2.7]
synonym: "glutathione thioesterase activity" EXACT []
synonym: "S-acylglutathione hydrolase activity" RELATED [EC:3.1.2.7]
xref: EC:3.1.2.7
xref: KEGG_REACTION:R00547
xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN
xref: RHEA:22708
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0047952
name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
alt_id: GO:0004367
alt_id: GO:0036439
alt_id: GO:0106257
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, PMID:28326]
comment: This term is to annotate enzymes that can use either NAD+ or NADP+ as a cofactors. This activity is present in bacteria.
synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT []
synonym: "hydroglycerophosphate dehydrogenase activity" BROAD []
synonym: "L-alpha-glycerol phosphate dehydrogenase activity" BROAD []
synonym: "L-alpha-glycerophosphate dehydrogenase activity" BROAD []
synonym: "L-glycerol phosphate dehydrogenase activity" BROAD []
synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" RELATED [EC:1.1.1.94]
synonym: "L-glycerophosphate dehydrogenase activity" BROAD []
synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.94]
xref: EC:1.1.1.94
xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN
xref: Reactome:R-HSA-75889 "DHAP is converted to G3P by GPD1/GPD1L"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047953
name: glycerol 2-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NADP+ = glycerone + H+ + NADPH." [EC:1.1.1.156, RHEA:12753]
synonym: "DHA oxidoreductase activity" RELATED [EC:1.1.1.156]
synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.1.1.156]
synonym: "dihydroxyacetone reductase (NADPH)" RELATED [EC:1.1.1.156]
synonym: "dihydroxyacetone reductase activity" RELATED [EC:1.1.1.156]
synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" RELATED [EC:1.1.1.156]
xref: EC:1.1.1.156
xref: KEGG_REACTION:R01039
xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN
xref: RHEA:12753
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047954
name: glycerol-2-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.19, RHEA:13105]
synonym: "2-glycerophosphatase activity" RELATED [EC:3.1.3.19]
synonym: "beta-glycerophosphatase activity" RELATED [EC:3.1.3.19]
synonym: "beta-glycerophosphate phosphatase activity" RELATED [EC:3.1.3.19]
synonym: "glycerol-2-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.19]
xref: EC:3.1.3.19
xref: KEGG_REACTION:R01043
xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN
xref: RHEA:13105
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047955
name: glycerol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: A + glycerol = AH(2) + glycerone." [EC:1.1.99.22, RHEA:17493]
synonym: "glycerol:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.22]
synonym: "glycerol:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.22]
xref: EC:1.1.99.22
xref: KEGG_REACTION:R01045
xref: MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:17493
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047956
name: glycerol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [RHEA:23592]
synonym: "glycerol dehydrogenase [NADP+] activity" RELATED []
synonym: "glycerol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.72]
xref: EC:1.1.1.72
xref: MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN
xref: RHEA:23592
is_a: GO:1990042 ! glycerol dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0047957
name: 4'-methoxyisoflavone 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.14.89, MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN]
synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" RELATED [EC:1.14.14.89]
synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.14.89]
xref: EC:1.14.14.89
xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN
xref: RHEA:12388
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047958
name: glycine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN]
synonym: "glutamate-glyoxylate transaminase activity" EXACT []
synonym: "glutamic-glyoxylic transaminase activity" RELATED [EC:2.6.1.4]
synonym: "glycine aminotransferase activity" BROAD []
synonym: "glycine transaminase activity" BROAD [EC:2.6.1.4]
synonym: "glyoxylate-glutamate aminotransferase activity" RELATED [EC:2.6.1.4]
synonym: "glyoxylate-glutamic transaminase activity" RELATED [EC:2.6.1.4]
synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT []
xref: EC:2.6.1.4
xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN
xref: RHEA:14089
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047959
name: glycine dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "glycine-cytochrome c reductase activity" RELATED [EC:1.4.2.1]
synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" RELATED [EC:1.4.2.1]
synonym: "reductase, glycine-cytochrome c" RELATED [EC:1.4.2.1]
xref: EC:1.4.2.1
xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN
xref: RHEA:16909
is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor

[Term]
id: GO:0047960
name: glycine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN]
synonym: "glycine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.10]
xref: EC:1.4.1.10
xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN
xref: RHEA:15721
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047961
name: glycine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:glycine N-acyltransferase activity" RELATED [EC:2.3.1.13]
synonym: "glycine acyltransferase activity" RELATED [EC:2.3.1.13]
synonym: "glycine-N-acylase activity" RELATED [EC:2.3.1.13]
xref: EC:2.3.1.13
xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN
xref: Reactome:R-HSA-2534040 "Unknown NAT N-acylates Gly in GNAT1"
xref: RHEA:19869
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0047962
name: glycine N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H+." [EC:2.3.1.71, RHEA:18493]
synonym: "benzoyl CoA-amino acid N-acyltransferase activity" RELATED [EC:2.3.1.71]
synonym: "benzoyl-CoA:glycine N-acyltransferase activity" RELATED [EC:2.3.1.71]
synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" RELATED [EC:2.3.1.71]
xref: EC:2.3.1.71
xref: KEGG_REACTION:R02452
xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN
xref: Reactome:R-HSA-159566 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A"
xref: Reactome:R-HSA-159574 "GLYAT-like proteins transfer glycine to ST-CoA to form SUA"
xref: Reactome:R-HSA-9750001 "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid"
xref: RHEA:18493
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047963
name: glycine N-choloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN]
synonym: "amino acid N-choloyltransferase activity" RELATED [EC:2.3.1.65]
synonym: "BACAT activity" RELATED [EC:2.3.1.65]
synonym: "BAT activity" RELATED [EC:2.3.1.65]
synonym: "bile acid-CoA:amino acid N-acyltransferase activity" RELATED [EC:2.3.1.65]
synonym: "choloyl-CoA:glycine N-choloyltransferase activity" RELATED [EC:2.3.1.65]
synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" RELATED [EC:2.3.1.65]
synonym: "cholyl-CoA:taurine N-acyltransferase activity" RELATED [EC:2.3.1.65]
synonym: "glycine--taurine N-acyltransferase activity" RELATED [EC:2.3.1.65]
xref: EC:2.3.1.65
xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN
xref: RHEA:14001
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0047964
name: glyoxylate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [RHEA:18229]
synonym: "glycolate reductase activity" RELATED [EC:1.1.1.26]
synonym: "glyoxylic acid reductase activity" RELATED [EC:1.1.1.26]
synonym: "NADH-dependent glyoxylate reductase activity" RELATED [EC:1.1.1.26]
xref: EC:1.1.1.26
xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN
xref: RHEA:18229
is_a: GO:0106345 ! glyoxylate reductase activity

[Term]
id: GO:0047965
name: glycoprotein O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN]
synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" RELATED [EC:2.3.1.142]
synonym: "protein acyltransferase activity" RELATED [EC:2.3.1.142]
xref: EC:2.3.1.142
xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN
is_a: GO:0016416 ! O-palmitoyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein

[Term]
id: GO:0047966
name: glycosulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + H+ + sulfate." [EC:3.1.6.3, RHEA:19145]
synonym: "glucosulfatase activity" RELATED [EC:3.1.6.3]
synonym: "glycosulphatase activity" EXACT []
synonym: "sugar-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.3]
xref: EC:3.1.6.3
xref: KEGG_REACTION:R00534
xref: MetaCyc:GLYCOSULFATASE-RXN
xref: RHEA:19145
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047967
name: glycyrrhizinate beta-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycyrrhizate + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, RHEA:17369]
synonym: "glycyrrhizin beta-hydrolase activity" RELATED [EC:3.2.1.128]
synonym: "glycyrrhizin hydrolase activity" RELATED [EC:3.2.1.128]
synonym: "glycyrrhizinate b-glucuronidase activity" EXACT []
synonym: "glycyrrhizinate glucuronosylhydrolase activity" RELATED [EC:3.2.1.128]
synonym: "glycyrrhizinic acid hydrolase activity" RELATED [EC:3.2.1.128]
xref: EC:3.2.1.128
xref: KEGG_REACTION:R03906
xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN
xref: RHEA:17369
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047968
name: glyoxylate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA." [EC:1.2.1.17, RHEA:21024]
synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" RELATED [EC:1.2.1.17]
xref: EC:1.2.1.17
xref: KEGG_REACTION:R00468
xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN
xref: RHEA:21024
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047969
name: glyoxylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate." [RHEA:14837]
synonym: "glyoxylate:oxygen oxidoreductase activity" RELATED [EC:1.2.3.5]
xref: EC:1.2.3.5
xref: KEGG_REACTION:R00466
xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN
xref: Reactome:R-HSA-389862 "Conversion of glyoxylate to oxalate"
xref: RHEA:14837
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0047970
name: guanidinoacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea." [EC:3.5.3.2, RHEA:23268]
synonym: "glycocyaminase activity" RELATED [EC:3.5.3.2]
synonym: "guanidinoacetate amidinohydrolase activity" RELATED [EC:3.5.3.2]
xref: EC:3.5.3.2
xref: KEGG_REACTION:R00775
xref: MetaCyc:GUANIDINOACETASE-RXN
xref: RHEA:23268
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047971
name: guanidinobutyrase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea." [EC:3.5.3.7, RHEA:19501]
synonym: "4-guanidinobutanoate amidinohydrolase activity" RELATED [EC:3.5.3.7]
synonym: "4-guanidinobutyrate amidinobutyrase activity" RELATED [EC:3.5.3.7]
synonym: "G-base activity" RELATED [EC:3.5.3.7]
synonym: "gamma-guanidinobutyrate amidinohydrolase activity" RELATED [EC:3.5.3.7]
synonym: "gamma-guanidobutyrase activity" RELATED [EC:3.5.3.7]
synonym: "GBH" RELATED [EC:3.5.3.7]
synonym: "guanidinobutyrate ureahydrolase activity" RELATED [EC:3.5.3.7]
xref: EC:3.5.3.7
xref: KEGG_REACTION:R01990
xref: MetaCyc:GUANIDINOBUTYRASE-RXN
xref: RHEA:19501
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047972
name: guanidinopropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea." [EC:3.5.3.17, RHEA:16029]
synonym: "3-guanidinopropanoate amidinopropionase activity" RELATED [EC:3.5.3.17]
synonym: "GPase activity" RELATED [EC:3.5.3.17]
synonym: "GPH" RELATED [EC:3.5.3.17]
xref: EC:3.5.3.17
xref: KEGG_REACTION:R00913
xref: MetaCyc:GUANIDINOPROPIONASE-RXN
xref: RHEA:16029
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047973
name: guanidinoacetate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H+ + phosphoguanidinoacetate." [EC:2.7.3.1, RHEA:14145]
synonym: "ATP:guanidinoacetate N-phosphotransferase activity" RELATED [EC:2.7.3.1]
synonym: "glycocyamine kinase activity" RELATED [EC:2.7.3.1]
synonym: "guanidoacetate kinase activity" EXACT []
xref: EC:2.7.3.1
xref: KEGG_REACTION:R02575
xref: MetaCyc:GUANIDOACETATE-KINASE-RXN
xref: RHEA:14145
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047974
name: guanosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]
synonym: "guanosine aminase activity" RELATED [EC:3.5.4.15]
synonym: "guanosine aminohydrolase activity" RELATED [EC:3.5.4.15]
xref: EC:3.5.4.15
xref: MetaCyc:GUANOSINE-DEAMINASE-RXN
xref: RHEA:12861
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047975
name: guanosine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15]
synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.15]
synonym: "guanosine:phosphate D-ribosyltransferase activity" RELATED [EC:2.4.2.15]
xref: EC:2.4.2.15
xref: MetaCyc:RXN0-5199
xref: RHEA:13233
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0047976
name: hamamelose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H+." [EC:2.7.1.102, RHEA:22796]
synonym: "ATP/hamamelose 2'-phosphotransferase activity" RELATED [EC:2.7.1.102]
synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" RELATED [EC:2.7.1.102]
synonym: "hamamelose kinase (phosphorylating)" RELATED [EC:2.7.1.102]
synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" RELATED [EC:2.7.1.102]
xref: EC:2.7.1.102
xref: KEGG_REACTION:R03766
xref: MetaCyc:HAMAMELOSE-KINASE-RXN
xref: RHEA:22796
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047977
name: hepoxilin-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN]
synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" RELATED [EC:3.3.2.7]
synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7]
synonym: "hepoxilin A3 hydrolase activity" RELATED [EC:3.3.2.7]
synonym: "hepoxilin epoxide hydrolase activity" RELATED [EC:3.3.2.7]
synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7]
xref: EC:3.3.2.7
xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN
xref: Reactome:R-HSA-2161949 "HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH"
xref: RHEA:16665
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0047978
name: hexadecanol (NAD+) dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN]
synonym: "hexadecanol dehydrogenase activity" BROAD []
synonym: "hexadecanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.164]
xref: EC:1.1.1.164
xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN
xref: RHEA:22056
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0047979
name: hexose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202." [EC:1.1.3.5]
synonym: "D-hexose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.5]
xref: EC:1.1.3.5
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047980
name: hippurate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzoylglycine + H2O = benzoate + glycine." [EC:3.5.1.32, RHEA:10424]
synonym: "benzoylglycine amidohydrolase activity" RELATED [EC:3.5.1.32]
synonym: "hippuricase activity" RELATED [EC:3.5.1.32]
synonym: "N-benzoylamino-acid amidohydrolase activity" RELATED [EC:3.5.1.32]
xref: EC:3.5.1.32
xref: KEGG_REACTION:R01424
xref: MetaCyc:HIPPURATE-HYDROLASE-RXN
xref: RHEA:10424
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047981
name: histidine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+." [EC:2.3.1.33, RHEA:24596]
synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" RELATED [EC:2.3.1.33]
synonym: "acetylhistidine synthetase activity" RELATED [EC:2.3.1.33]
synonym: "histidine acetyltransferase activity" RELATED [EC:2.3.1.33]
xref: EC:2.3.1.33
xref: KEGG_REACTION:R01160
xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:24596
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047982
name: homocysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN]
synonym: "homocysteine desulfurase activity" RELATED [EC:4.4.1.2]
synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" RELATED [EC:4.4.1.2]
synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" RELATED [EC:4.4.1.2]
xref: EC:4.4.1.2
xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN
xref: Reactome:R-HSA-1614631 "Homocysteine is degraded to oxobutanoate and H2S"
xref: RHEA:14501
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047983
name: homoglutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H+ + phosphate." [EC:6.3.2.23, RHEA:17993]
synonym: "beta-alanine specific hGSH synthetase activity" RELATED [EC:6.3.2.23]
synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.23]
synonym: "homoglutathione synthetase activity" RELATED [EC:6.3.2.23]
xref: EC:6.3.2.23
xref: KEGG_REACTION:R02741
xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN
xref: RHEA:17993
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047985
name: hydrogen dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN]
synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2]
synonym: "H(2):NAD(+) oxidoreductase activity" RELATED [EC:1.12.1.2]
synonym: "H2:NAD+ oxidoreductase activity" RELATED [EC:1.12.1.2]
synonym: "hydrogen:NAD+ oxidoreductase activity" RELATED [EC:1.12.1.2]
synonym: "hydrogenase activity" BROAD [EC:1.12.1.2]
synonym: "NAD-linked hydrogenase activity" RELATED [EC:1.12.1.2]
xref: EC:1.12.1.2
xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN
xref: RHEA:24636
is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

[Term]
id: GO:0047986
name: hydrogen-sulfide S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate." [EC:2.3.1.10, RHEA:16625]
synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" RELATED [EC:2.3.1.10]
synonym: "hydrogen-sulfide acetyltransferase activity" RELATED [EC:2.3.1.10]
synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT []
xref: EC:2.3.1.10
xref: KEGG_REACTION:R01850
xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN
xref: RHEA:16625
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0047988
name: hydroxyacid-oxoacid transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN]
synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" RELATED [EC:1.1.99.24]
synonym: "transhydrogenase, hydroxy acid-oxo acid" RELATED [EC:1.1.99.24]
xref: EC:1.1.99.24
xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN
xref: Reactome:R-HSA-880002 "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate"
xref: Reactome:R-HSA-880033 "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde"
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047989
name: hydroxybutyrate-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H2O = 2 (R)-3-hydroxybutanoate + H+." [EC:3.1.1.22, RHEA:10172]
synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" RELATED [EC:3.1.1.22]
synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" RELATED [EC:3.1.1.22]
xref: EC:3.1.1.22
xref: KEGG_REACTION:R00048
xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN
xref: RHEA:10172
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047990
name: hydroxyglutamate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-L-glutamate + H+ = 4-amino-3-hydroxybutanoate + CO2." [EC:4.1.1.16, RHEA:14073]
synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" RELATED [EC:4.1.1.16]
synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" RELATED [EC:4.1.1.16]
xref: EC:4.1.1.16
xref: KEGG_REACTION:R04135
xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN
xref: RHEA:14073
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047991
name: hydroxylamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxylamine + O2 = H2O + H+ + nitrite." [RHEA:19969]
synonym: "HAO" RELATED [EC:1.7.3.6]
synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.6]
synonym: "hydroxylamine:oxygen oxidoreductase activity" RELATED [EC:1.7.3.6]
xref: EC:1.7.3.6
xref: KEGG_REACTION:R00793
xref: MetaCyc:RXN-13595
xref: RHEA:19969
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047992
name: hydroxylysine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H+." [EC:2.7.1.81, RHEA:19049]
synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" RELATED [EC:2.7.1.81]
synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" RELATED [EC:2.7.1.81]
synonym: "hydroxylysine kinase (phosphorylating)" RELATED [EC:2.7.1.81]
xref: EC:2.7.1.81
xref: KEGG_REACTION:R03378
xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN
xref: Reactome:R-HSA-6788611 "HYKK phosphorylates 5HLYS"
xref: RHEA:19049
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0047993
name: hydroxymalonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymalonate + NAD+ = H+ + NADH + oxomalonate." [EC:1.1.1.167, RHEA:11284]
synonym: "hydroxymalonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.167]
xref: EC:1.1.1.167
xref: KEGG_REACTION:R02969
xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN
xref: RHEA:11284
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047994
name: hydroxymethylglutaryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+." [EC:3.1.2.5, RHEA:16305]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" RELATED [EC:3.1.2.5]
synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" RELATED [EC:3.1.2.5]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" RELATED [EC:3.1.2.5]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" RELATED [EC:3.1.2.5]
synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" RELATED [EC:3.1.2.5]
synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" RELATED [EC:3.1.2.5]
xref: EC:3.1.2.5
xref: KEGG_REACTION:R02083
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN
xref: RHEA:16305
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0047995
name: hydroxyphenylpyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [RHEA:10780]
synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.237]
synonym: "HPRP" RELATED [EC:1.1.1.237]
xref: EC:1.1.1.237
xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN
xref: RHEA:10780
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047996
name: hydroxyphytanate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2." [EC:1.1.3.27, RHEA:21680]
synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27]
xref: EC:1.1.3.27
xref: KEGG_REACTION:R07151
xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN
xref: RHEA:21680
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047997
name: hydroxypyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypyruvate + H+ = CO2 + glycolaldehyde." [EC:4.1.1.40, RHEA:20561]
synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" RELATED [EC:4.1.1.40]
synonym: "hydroxypyruvate carboxy-lyase activity" RELATED [EC:4.1.1.40]
xref: EC:4.1.1.40
xref: KEGG_REACTION:R01393
xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN
xref: RHEA:20561
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047998
name: hyoscyamine (6S)-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate." [EC:1.14.11.11, RHEA:12629]
synonym: "hyoscyamine (6S)-hydroxylase activity" RELATED [EC:1.14.11.11]
synonym: "hyoscyamine 6-beta-hydroxylase activity" RELATED [EC:1.14.11.11]
synonym: "hyoscyamine 6-hydroxylase activity" RELATED [EC:1.14.11.11]
synonym: "hyoscyamine 6beta-dioxygenase activity" RELATED [EC:1.14.11.11]
synonym: "hyoscyamine 6beta-hydroxylase activity" RELATED [EC:1.14.11.11]
synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" RELATED [EC:1.14.11.11]
xref: EC:1.14.11.11
xref: KEGG_REACTION:R03812
xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN
xref: RHEA:12629
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0047999
name: hyponitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = 2 H+ + hyponitrous acid + 2 NADH." [EC:1.7.1.5, RHEA:19337]
synonym: "hydroxylamine:NAD+ oxidoreductase activity" RELATED [EC:1.7.1.5]
synonym: "NADH2:hyponitrite oxidoreductase activity" RELATED [EC:1.7.1.5]
synonym: "NADH:hyponitrite oxidoreductase activity" RELATED [EC:1.7.1.5]
xref: EC:1.7.1.5
xref: KEGG_REACTION:R00023
xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN
xref: RHEA:19337
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0048000
name: isoflavone 3'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.14.88]
synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.88]
synonym: "isoflavone 3'-monooxygenase activity" RELATED [EC:1.14.14.88]
xref: EC:1.14.14.88
xref: MetaCyc:RXN-3762
xref: RHEA:22960
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0048001
name: erythrose-4-phosphate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0033724
def: "Catalysis of the reaction: D-erythrose 4-phosphate + H2O + NAD+ = 4-phospho-D-erythronate + 2 H+ + NADH." [EC:1.2.1.72, RHEA:12056]
synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.72]
synonym: "E4P dehydrogenase activity" RELATED [EC:1.2.1.72]
synonym: "E4PDH" RELATED [EC:1.2.1.72]
synonym: "Epd dehydrogenase activity" RELATED [EC:1.2.1.72]
synonym: "erythrose 4-phosphate dehydrogenase activity" RELATED [EC:1.2.1.72]
synonym: "GapB" RELATED [EC:1.2.1.72]
xref: EC:1.2.1.72
xref: KEGG_REACTION:R01825
xref: MetaCyc:ERYTH4PDEHYDROG-RXN
xref: RHEA:12056
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0048002
name: antigen processing and presentation of peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, peptide antigen" EXACT []
synonym: "peptide antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0048003
name: antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, lipid antigen" EXACT []
synonym: "lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0048006
name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, endogenous lipid antigen" EXACT []
synonym: "endogenous lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0048007
name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, exogenous peptide antigen" EXACT []
synonym: "exogenous lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0048008
name: platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]
synonym: "PDGF receptor signaling pathway" EXACT []
synonym: "PDGF receptor signalling pathway" EXACT []
synonym: "PDGFR signaling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048009
name: insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]
synonym: "IGF receptor signaling pathway" EXACT []
synonym: "IGF receptor signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048010
name: vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
synonym: "VEGF receptor signaling pathway" EXACT []
synonym: "VEGF receptor signalling pathway" EXACT []
synonym: "VEGFR signaling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048011
name: neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]
synonym: "TrkA signaling pathway" NARROW [Wikipedia:TrkA]
synonym: "TrkB signaling pathway" NARROW [Wikipedia:TrkB]
synonym: "TrkC signaling pathway" NARROW [Wikipedia:TrkC]
synonym: "tropomyosin-receptor-kinase signaling" EXACT [Wikipedia:Trk_receptor]
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
is_a: GO:0038179 ! neurotrophin signaling pathway

[Term]
id: GO:0048012
name: hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]
synonym: "HGF receptor signaling pathway" EXACT []
synonym: "HGF receptor signalling pathway" EXACT []
synonym: "Met signaling pathway" NARROW []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048013
name: ephrin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]
synonym: "Eph receptor signaling pathway" EXACT []
synonym: "Eph receptor signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048014
name: Tie signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling, PMID:11283723, PMID:11566266]
synonym: "angiopoietin-Tie signaling pathway" NARROW [PMID:22951441]
synonym: "angiopoietin/Tie signaling pathway" NARROW [PMID:11566266]
synonym: "Tek receptor signaling" EXACT []
synonym: "Tie receptor signaling pathway" EXACT [GOC:ceb]
synonym: "Tie receptor signalling pathway" EXACT []
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048015
name: phosphatidylinositol-mediated signaling
namespace: biological_process
def: "The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]
synonym: "inositol phospholipid-mediated signaling" BROAD []
synonym: "phosphatidylinositol-mediated signal transduction" EXACT [GOC:signaling]
synonym: "phosphatidylinositol-mediated signalling" EXACT []
synonym: "phosphoinositide-mediated signaling" EXACT []
synonym: "phosphoinositide-mediated signalling" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0048016
name: obsolete inositol phosphate-mediated signaling
namespace: biological_process
def: "OBSOLETE. A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6)." [GOC:bf, GOC:ceb, GOC:signaling, ISBN:0198506732, PMID:11331907]
comment: This term was obsoleted because it was not clearly defined and represented several pathways in which the level of some inositol phosphate level was altered.
synonym: "inositol phosphate-mediated signalling" EXACT []
is_obsolete: true
consider: GO:0019722
consider: GO:0043491

[Term]
id: GO:0048017
name: obsolete inositol lipid-mediated signaling
namespace: biological_process
def: "OBSOLETE. The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids." [GOC:bf, GOC:ceb, PMID:16088939]
comment: This term was obsoleted because it did not clearly define a signal transduction pathway.
synonym: "inositol lipid-mediated signal transduction" EXACT [GOC:signaling]
synonym: "inositol lipid-mediated signalling" EXACT []
synonym: "inositol phospholipid-mediated signaling" NARROW []
is_obsolete: true
consider: GO:0035556

[Term]
id: GO:0048018
name: receptor ligand activity
namespace: molecular_function
alt_id: GO:0071884
def: "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
synonym: "receptor agonist activity" BROAD [GOC:molecular_function_refactoring]
synonym: "signaling molecule" EXACT []
synonym: "signaling receptor ligand activity" EXACT []
xref: Reactome:R-HSA-163625 "Glucagon binds to Glucagon receptor"
xref: Reactome:R-HSA-381612 "GLP1R binds GLP1"
is_a: GO:0005102 ! signaling receptor binding
is_a: GO:0030546 ! signaling receptor activator activity

[Term]
id: GO:0048019
name: receptor antagonist activity
namespace: molecular_function
def: "The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor." [GOC:ceb, ISBN:0198506732]
synonym: "receptor ligand activity" BROAD [GOC:mtg_signaling]
is_a: GO:0005102 ! signaling receptor binding
is_a: GO:0030547 ! signaling receptor inhibitor activity

[Term]
id: GO:0048020
name: CCR chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR chemokine receptor." [GOC:ai]
synonym: "beta chemokine receptor binding" EXACT []
synonym: "beta chemokine receptor ligand" NARROW []
synonym: "CCR chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0048021
name: regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]
synonym: "regulation of melanin anabolism" EXACT []
synonym: "regulation of melanin biosynthesis" EXACT []
synonym: "regulation of melanin formation" EXACT []
synonym: "regulation of melanin synthesis" EXACT []
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048022
name: negative regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]
synonym: "down regulation of melanin biosynthetic process" EXACT []
synonym: "down-regulation of melanin biosynthetic process" EXACT []
synonym: "downregulation of melanin biosynthetic process" EXACT []
synonym: "inhibition of melanin biosynthetic process" NARROW []
synonym: "negative regulation of melanin anabolism" EXACT []
synonym: "negative regulation of melanin biosynthesis" EXACT []
synonym: "negative regulation of melanin formation" EXACT []
synonym: "negative regulation of melanin synthesis" EXACT []
is_a: GO:0048021 ! regulation of melanin biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
relationship: negatively_regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048023
name: positive regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]
synonym: "activation of melanin biosynthetic process" NARROW []
synonym: "positive regulation of melanin anabolism" EXACT []
synonym: "positive regulation of melanin biosynthesis" EXACT []
synonym: "positive regulation of melanin formation" EXACT []
synonym: "positive regulation of melanin synthesis" EXACT []
synonym: "stimulation of melanin biosynthetic process" NARROW []
synonym: "up regulation of melanin biosynthetic process" EXACT []
synonym: "up-regulation of melanin biosynthetic process" EXACT []
synonym: "upregulation of melanin biosynthetic process" EXACT []
is_a: GO:0048021 ! regulation of melanin biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
relationship: positively_regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048024
name: regulation of mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035055
def: "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
synonym: "regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "regulation of pre-mRNA splicing" BROAD []
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:0050684 ! regulation of mRNA processing
relationship: regulates GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0048025
name: negative regulation of mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035056
def: "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
synonym: "down regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "down regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "down-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "down-regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "downregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "downregulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "inhibition of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "inhibition of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "negative regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "negative regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "negative regulation of pre-mRNA splicing" BROAD []
is_a: GO:0033119 ! negative regulation of RNA splicing
is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome
is_a: GO:0050686 ! negative regulation of mRNA processing
relationship: negatively_regulates GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0048026
name: positive regulation of mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035057
def: "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
synonym: "activation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "activation of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "positive regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "positive regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "positive regulation of pre-mRNA splicing" BROAD []
synonym: "stimulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "stimulation of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "up regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "up regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "up-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "up-regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "upregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "upregulation of nuclear mRNA splicing, via spliceosome" EXACT []
is_a: GO:0033120 ! positive regulation of RNA splicing
is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome
is_a: GO:0050685 ! positive regulation of mRNA processing
relationship: positively_regulates GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0048027
name: mRNA 5'-UTR binding
namespace: molecular_function
def: "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]
synonym: "mRNA 5' UTR binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0048028
name: galacturonan binding
namespace: molecular_function
def: "Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jid]
synonym: "polygalacturonide binding" RELATED []
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0048029
name: monosaccharide binding
namespace: molecular_function
def: "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]
is_a: GO:0030246 ! carbohydrate binding
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0048030
name: disaccharide binding
namespace: molecular_function
def: "Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jid]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0048031
name: trisaccharide binding
namespace: molecular_function
def: "Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jid]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0048032
name: galacturonate binding
namespace: molecular_function
def: "Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:jid]
synonym: "galacturonic acid binding" EXACT []
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0048033
name: heme O metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid]
synonym: "haem O metabolic process" EXACT []
synonym: "haem O metabolism" EXACT []
synonym: "heme O metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0048034
name: heme O biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid]
synonym: "haem O biosynthesis" EXACT []
synonym: "haem O biosynthetic process" EXACT []
synonym: "heme O anabolism" EXACT []
synonym: "heme O biosynthesis" EXACT []
synonym: "heme O formation" EXACT []
synonym: "heme O synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0048033 ! heme O metabolic process

[Term]
id: GO:0048035
name: heme O catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid]
synonym: "haem O catabolic process" EXACT []
synonym: "haem O catabolism" EXACT []
synonym: "heme O breakdown" EXACT []
synonym: "heme O catabolism" EXACT []
synonym: "heme O degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0048033 ! heme O metabolic process

[Term]
id: GO:0048036
name: central complex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252]
synonym: "central body development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0048037
name: obsolete cofactor binding
namespace: molecular_function
def: "OBSOLETE. Binding to a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a cofactor.
is_obsolete: true

[Term]
id: GO:0048038
name: quinone binding
namespace: molecular_function
def: "Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0048039
name: ubiquinone binding
namespace: molecular_function
def: "Binding to ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089]
synonym: "coenzyme Q binding" EXACT []
synonym: "coenzyme Q6 binding" NARROW []
is_a: GO:0048038 ! quinone binding

[Term]
id: GO:0048040
name: UDP-glucuronate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose." [EC:4.1.1.35, RHEA:23916]
synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" RELATED [EC:4.1.1.35]
synonym: "UDP-D-glucuronate carboxy-lyase activity" RELATED [EC:4.1.1.35]
synonym: "UDP-glucuronic acid decarboxylase activity" EXACT []
synonym: "UDPglucuronate decarboxylase activity" RELATED [EC:4.1.1.35]
synonym: "uridine-diphosphoglucuronate decarboxylase activity" RELATED [EC:4.1.1.35]
xref: EC:4.1.1.35
xref: KEGG_REACTION:R01384
xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN
xref: Reactome:R-HSA-8863761 "UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xylose"
xref: RHEA:23916
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0048041
name: focal adhesion assembly
namespace: biological_process
def: "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah]
synonym: "adhesion plaque assembly" RELATED []
synonym: "focal adhesion formation" RELATED [GOC:mah]
is_a: GO:0007044 ! cell-substrate junction assembly
relationship: part_of GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0048045
name: obsolete trans-pentaprenyltranstransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate." [GOC:curators]
comment: RHEA has obsoleted the xref to this term and replaced it with a term specifying FAD, not NAD
synonym: "all-trans-hexaprenyl-diphosphate synthase activity" RELATED []
synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" RELATED []
synonym: "hexaprenyl diphosphate synthase activity" RELATED []
synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0048046
name: apoplast
namespace: cellular_component
def: "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jid]
xref: Wikipedia:Apoplast
is_a: GO:0005576 ! extracellular region

[Term]
id: GO:0048047
name: mating behavior, sex discrimination
namespace: biological_process
def: "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
synonym: "mating behaviour, sex discrimination" EXACT []
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0048048
name: embryonic eye morphogenesis
namespace: biological_process
def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048050
name: post-embryonic eye morphogenesis
namespace: biological_process
alt_id: GO:0048051
def: "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight." [GOC:jid, GOC:sensu]
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048052
name: R1/R6 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048053
name: R1/R6 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048052 ! R1/R6 cell differentiation

[Term]
id: GO:0048054
name: R2/R5 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048055
name: R2/R5 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048054 ! R2/R5 cell differentiation

[Term]
id: GO:0048056
name: R3/R4 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048057
name: R3/R4 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048056 ! R3/R4 cell differentiation

[Term]
id: GO:0048058
name: compound eye corneal lens development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0048060
name: negative gravitaxis
namespace: biological_process
alt_id: GO:0048063
def: "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid]
synonym: "negative geotactic behavior" EXACT []
synonym: "negative geotactic behaviour" EXACT []
synonym: "negative gravitactic behavior" EXACT []
synonym: "negative gravitactic behaviour" EXACT []
synonym: "negative taxis in response to gravity" EXACT []
synonym: "negative taxis in response to gravitytaxis in response to gravitational stimulus" EXACT []
is_a: GO:0042332 ! gravitaxis

[Term]
id: GO:0048061
name: positive gravitaxis
namespace: biological_process
alt_id: GO:0048064
def: "The directed movement of a motile cell or organism towards the source of gravity." [GOC:jid]
synonym: "positive geotactic behavior" EXACT []
synonym: "positive geotactic behaviour" EXACT []
synonym: "positive gravitactic behavior" EXACT []
synonym: "positive gravitactic behaviour" EXACT []
synonym: "positive taxis in response to gravity" EXACT []
synonym: "positive taxis in response to gravitytaxis in response to gravitational stimulus" EXACT []
is_a: GO:0042332 ! gravitaxis

[Term]
id: GO:0048065
name: male courtship behavior, veined wing extension
namespace: biological_process
def: "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
synonym: "male courtship behavior, wing extension" BROAD []
synonym: "male courtship behaviour, veined wing extension" EXACT []
synonym: "male courtship behaviour, wing extension" BROAD []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0048066
name: developmental pigmentation
namespace: biological_process
def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
synonym: "pigmentation during development" RELATED []
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0048067
name: cuticle pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
is_a: GO:0048066 ! developmental pigmentation
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0048069
name: eye pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
xref: Wikipedia:Eye_color
is_a: GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048070
name: regulation of developmental pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb]
is_a: GO:0120305 ! regulation of pigmentation
relationship: regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048071
name: sex-specific pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048066 ! developmental pigmentation
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0048072
name: compound eye pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the compound eye." [GOC:jid]
is_a: GO:0048069 ! eye pigmentation

[Term]
id: GO:0048073
name: regulation of eye pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
relationship: regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048074
name: negative regulation of eye pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
synonym: "down regulation of eye pigmentation" EXACT []
synonym: "down-regulation of eye pigmentation" EXACT []
synonym: "downregulation of eye pigmentation" EXACT []
synonym: "inhibition of eye pigmentation" NARROW []
is_a: GO:0048073 ! regulation of eye pigmentation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
relationship: negatively_regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048075
name: positive regulation of eye pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
synonym: "activation of eye pigmentation" NARROW []
synonym: "stimulation of eye pigmentation" NARROW []
synonym: "up regulation of eye pigmentation" EXACT []
synonym: "up-regulation of eye pigmentation" EXACT []
synonym: "upregulation of eye pigmentation" EXACT []
is_a: GO:0048073 ! regulation of eye pigmentation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
relationship: positively_regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048076
name: regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
is_a: GO:0048073 ! regulation of eye pigmentation
relationship: regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048077
name: negative regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
synonym: "down regulation of eye pigmentation" BROAD []
synonym: "down-regulation of eye pigmentation" BROAD []
synonym: "downregulation of eye pigmentation" BROAD []
synonym: "inhibition of eye pigmentation" BROAD []
synonym: "negative regulation of eye pigmentation" BROAD []
is_a: GO:0048074 ! negative regulation of eye pigmentation
is_a: GO:0048076 ! regulation of compound eye pigmentation
relationship: negatively_regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048078
name: positive regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
synonym: "activation of eye pigmentation" BROAD []
synonym: "positive regulation of eye pigmentation" BROAD []
synonym: "stimulation of eye pigmentation" BROAD []
synonym: "up regulation of eye pigmentation" BROAD []
synonym: "up-regulation of eye pigmentation" BROAD []
synonym: "upregulation of eye pigmentation" BROAD []
is_a: GO:0048075 ! positive regulation of eye pigmentation
is_a: GO:0048076 ! regulation of compound eye pigmentation
relationship: positively_regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048079
name: regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
relationship: regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048080
name: negative regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
synonym: "down regulation of cuticle pigmentation" EXACT []
synonym: "down-regulation of cuticle pigmentation" EXACT []
synonym: "downregulation of cuticle pigmentation" EXACT []
synonym: "inhibition of cuticle pigmentation" NARROW []
is_a: GO:0048079 ! regulation of cuticle pigmentation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048081
name: positive regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
synonym: "activation of cuticle pigmentation" NARROW []
synonym: "stimulation of cuticle pigmentation" NARROW []
synonym: "up regulation of cuticle pigmentation" EXACT []
synonym: "up-regulation of cuticle pigmentation" EXACT []
synonym: "upregulation of cuticle pigmentation" EXACT []
is_a: GO:0048079 ! regulation of cuticle pigmentation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048082
name: regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0048079 ! regulation of cuticle pigmentation
relationship: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048083
name: negative regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
synonym: "down regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "down-regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "downregulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "inhibition of adult chitin-containing cuticle pigmentation" NARROW []
is_a: GO:0045800 ! negative regulation of chitin-based cuticle tanning
is_a: GO:0048080 ! negative regulation of cuticle pigmentation
is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation
relationship: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048084
name: positive regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
synonym: "activation of adult chitin-containing cuticle pigmentation" NARROW []
synonym: "stimulation of adult chitin-containing cuticle pigmentation" NARROW []
synonym: "up regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "up-regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "upregulation of adult chitin-containing cuticle pigmentation" EXACT []
is_a: GO:0045801 ! positive regulation of chitin-based cuticle tanning
is_a: GO:0048081 ! positive regulation of cuticle pigmentation
is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation
relationship: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048085
name: adult chitin-containing cuticle pigmentation
namespace: biological_process
alt_id: GO:0048068
def: "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
synonym: "adult cuticle pigmentation" BROAD []
is_a: GO:0048067 ! cuticle pigmentation
relationship: part_of GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0048086
name: negative regulation of developmental pigmentation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of pigmentation" NARROW []
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048087
name: positive regulation of developmental pigmentation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph]
synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048088
name: regulation of male pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048089
name: regulation of female pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048090
name: negative regulation of female pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid]
synonym: "down regulation of female pigmentation" EXACT []
synonym: "down-regulation of female pigmentation" EXACT []
synonym: "downregulation of female pigmentation" EXACT []
synonym: "inhibition of female pigmentation" NARROW []
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0048089 ! regulation of female pigmentation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048091
name: positive regulation of female pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid]
synonym: "activation of female pigmentation" NARROW []
synonym: "stimulation of female pigmentation" NARROW []
synonym: "up regulation of female pigmentation" EXACT []
synonym: "up-regulation of female pigmentation" EXACT []
synonym: "upregulation of female pigmentation" EXACT []
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0048089 ! regulation of female pigmentation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048092
name: negative regulation of male pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid]
synonym: "down regulation of male pigmentation" EXACT []
synonym: "down-regulation of male pigmentation" EXACT []
synonym: "downregulation of male pigmentation" EXACT []
synonym: "inhibition of male pigmentation" NARROW []
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0048088 ! regulation of male pigmentation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048093
name: positive regulation of male pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid]
synonym: "activation of male pigmentation" NARROW []
synonym: "stimulation of male pigmentation" NARROW []
synonym: "up regulation of male pigmentation" EXACT []
synonym: "up-regulation of male pigmentation" EXACT []
synonym: "upregulation of male pigmentation" EXACT []
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0048088 ! regulation of male pigmentation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048094
name: male pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in males." [GOC:jid]
is_a: GO:0048071 ! sex-specific pigmentation
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0048095
name: female pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in females." [GOC:jid]
is_a: GO:0048071 ! sex-specific pigmentation
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0048097
name: obsolete long-term maintenance of gene activation
namespace: biological_process
def: "OBSOLETE. Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term." [GOC:jid]
comment: This term has been obsoleted because its definition was not clear, and had no references and no annotations.
is_obsolete: true
consider: GO:0045815

[Term]
id: GO:0048098
name: antennal joint development
namespace: biological_process
def: "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007469 ! antennal development

[Term]
id: GO:0048099
name: anterior/posterior lineage restriction, imaginal disc
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402]
is_a: GO:0035161 ! imaginal disc lineage restriction
relationship: part_of GO:0007448 ! anterior/posterior pattern specification, imaginal disc

[Term]
id: GO:0048100
name: wing disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531]
is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0048101
name: calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin." [GOC:jid, PMID:35216259]
synonym: "calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity" BROAD []
synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED []
synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT []
synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT []
synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT []
is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity

[Term]
id: GO:0048102
name: autophagic cell death
namespace: biological_process
def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517]
comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
synonym: "autophagic death" BROAD []
synonym: "autosis" RELATED [PMID:25236395]
synonym: "programmed cell death by autophagy" BROAD [GOC:pr]
synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm]
synonym: "type II programmed cell death" RELATED [GOC:sl]
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0048103
name: somatic stem cell division
namespace: biological_process
def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]
synonym: "somatic stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division

[Term]
id: GO:0048104
name: establishment of body hair or bristle planar orientation
namespace: biological_process
def: "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0048105
name: establishment of body hair planar orientation
namespace: biological_process
def: "Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]
is_a: GO:0048104 ! establishment of body hair or bristle planar orientation

[Term]
id: GO:0048106
name: establishment of thoracic bristle planar orientation
namespace: biological_process
def: "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction." [FBbt:00004298, FBbt:00004408, GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]
synonym: "establishment of body bristle planar orientation" EXACT [GOC:bf]
is_a: GO:0048104 ! establishment of body hair or bristle planar orientation
relationship: part_of GO:0008407 ! chaeta morphogenesis

[Term]
id: GO:0048107
name: 4-amino-3-isothiazolidinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively." [GOC:jid]
synonym: "4-amino-3-isothiazolidinone anabolism" EXACT []
synonym: "4-amino-3-isothiazolidinone biosynthesis" EXACT []
synonym: "4-amino-3-isothiazolidinone formation" EXACT []
synonym: "4-amino-3-isothiazolidinone synthesis" EXACT []
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0048108
name: obsolete peptide cross-linking via 4-amino-3-isothiazolidinone
namespace: biological_process
def: "OBSOLETE. The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue." [GOC:jid, GOC:jsg]
comment: This term was obsoleted because it represents a non-entymatic protein modification, see PMID:12802338.
is_obsolete: true

[Term]
id: GO:0048109
name: obsolete peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water." [GOC:jid, PMID:12802338, PMID:12802339, RESID:AA0344]
comment: This term was obsoleted because it represents a non-entymatic protein modification, see PMID:12802338.
xref: RESID:AA0344
is_obsolete: true

[Term]
id: GO:0048132
name: female germ-line stem cell asymmetric division
namespace: biological_process
alt_id: GO:0048141
def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
synonym: "female germ-line stem cell renewal" EXACT []
is_a: GO:0098728 ! germline stem cell asymmetric division
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0048133
name: male germ-line stem cell asymmetric division
namespace: biological_process
def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid]
synonym: "male germ-line stem cell renewal" EXACT []
is_a: GO:0098728 ! germline stem cell asymmetric division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048134
name: germ-line cyst formation
namespace: biological_process
def: "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
synonym: "germline cyst formation" EXACT [PMID:10370240]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0048135
name: female germ-line cyst formation
namespace: biological_process
def: "Formation of a group of interconnected cells derived from a single female gonial founder cell." [GOC:jid, PMID:10370240]
synonym: "female germline cyst formation" EXACT [PMID:10370240]
is_a: GO:0048134 ! germ-line cyst formation
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0048136
name: male germ-line cyst formation
namespace: biological_process
def: "Formation of a group of interconnected cells derived from a single male gonial founder cell." [GOC:jid, PMID:10370240]
synonym: "male germline cyst formation" EXACT [PMID:10370240]
is_a: GO:0048134 ! germ-line cyst formation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048137
name: spermatocyte division
namespace: biological_process
def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
synonym: "spermatocyte cell division" EXACT []
is_a: GO:0051301 ! cell division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048138
name: germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007276 ! gamete generation
relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium

[Term]
id: GO:0048139
name: female germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jid]
is_a: GO:0048138 ! germ-line cyst encapsulation
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0048140
name: male germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jid, PMID:11591336]
is_a: GO:0048138 ! germ-line cyst encapsulation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048142
name: germarium-derived cystoblast division
namespace: biological_process
def: "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529]
synonym: "germarium-derived cystoblast cell division" EXACT []
is_a: GO:0007282 ! cystoblast division
relationship: part_of GO:0030727 ! germarium-derived female germ-line cyst formation

[Term]
id: GO:0048143
name: astrocyte activation
namespace: biological_process
def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813]
is_a: GO:0061900 ! glial cell activation
relationship: part_of GO:0014002 ! astrocyte development

[Term]
id: GO:0048144
name: fibroblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0048145
name: regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048146
name: positive regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "activation of fibroblast proliferation" NARROW []
synonym: "stimulation of fibroblast proliferation" NARROW []
synonym: "up regulation of fibroblast proliferation" EXACT []
synonym: "up-regulation of fibroblast proliferation" EXACT []
synonym: "upregulation of fibroblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
relationship: positively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048147
name: negative regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "down regulation of fibroblast proliferation" EXACT []
synonym: "down-regulation of fibroblast proliferation" EXACT []
synonym: "downregulation of fibroblast proliferation" EXACT []
synonym: "inhibition of fibroblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
relationship: negatively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048148
name: behavioral response to cocaine
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
synonym: "behavioural response to cocaine" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0042220 ! response to cocaine

[Term]
id: GO:0048149
name: behavioral response to ethanol
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
synonym: "behavioural response to ethanol" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0045471 ! response to ethanol

[Term]
id: GO:0048150
name: behavioral response to ether
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of an ether stimulus." [GOC:jid]
synonym: "behavioural response to ether" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0045472 ! response to ether

[Term]
id: GO:0048151
name: obsolete hyperphosphorylation
namespace: biological_process
def: "OBSOLETE. The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both." [GOC:jid, ISBN:039751820X, PMID:12859672]
comment: This term was made obsolete because it is an unnecessary grouping term and was poorly defined.
synonym: "hyperphosphorylation" EXACT []
is_obsolete: true
replaced_by: GO:0016310

[Term]
id: GO:0048152
name: obsolete S100 beta biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "S100 beta anabolism" EXACT []
synonym: "S100 beta biosynthesis" EXACT []
synonym: "S100 beta formation" EXACT []
synonym: "S100 beta synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0048153
name: obsolete S100 alpha biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
synonym: "S100 alpha anabolism" EXACT []
synonym: "S100 alpha biosynthesis" EXACT []
synonym: "S100 alpha formation" EXACT []
synonym: "S100 alpha synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0048156
name: tau protein binding
namespace: molecular_function
def: "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0048158
name: oogonium stage
namespace: biological_process
def: "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 1" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048159
name: primary oocyte stage
namespace: biological_process
def: "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 2" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048160
name: primary follicle stage
namespace: biological_process
def: "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 3" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048161
name: double layer follicle stage
namespace: biological_process
def: "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 4" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048162
name: multi-layer follicle stage
namespace: biological_process
def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 5" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048163
name: scattered antral spaces stage
namespace: biological_process
def: "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 6" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048164
name: distinct antral spaces stage
namespace: biological_process
def: "The stage in oogenesis when the antral spaces become distinct and the first polar body forms." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 7" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048165
name: fused antrum stage
namespace: biological_process
def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 8" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048166
name: mature follicle stage
namespace: biological_process
def: "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 9" EXACT []
is_a: GO:0022605 ! mammalian oogenesis stage

[Term]
id: GO:0048167
name: regulation of synaptic plasticity
namespace: biological_process
def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0048168
name: regulation of neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0048169
name: regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0048170
name: positive regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of long-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW []
synonym: "up regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "up-regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "upregulation of long-term neuronal synaptic plasticity" EXACT []
is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity
is_a: GO:0050769 ! positive regulation of neurogenesis

[Term]
id: GO:0048171
name: negative regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "downregulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "inhibition of long-term neuronal synaptic plasticity" NARROW []
is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity
is_a: GO:0050768 ! negative regulation of neurogenesis

[Term]
id: GO:0048172
name: regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0048173
name: positive regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of short-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW []
synonym: "up regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "up-regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "upregulation of short-term neuronal synaptic plasticity" EXACT []
is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity
is_a: GO:0050769 ! positive regulation of neurogenesis

[Term]
id: GO:0048174
name: negative regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "downregulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "inhibition of short-term neuronal synaptic plasticity" NARROW []
is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity
is_a: GO:0050768 ! negative regulation of neurogenesis

[Term]
id: GO:0048179
name: activin receptor complex
namespace: cellular_component
def: "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651]
is_a: GO:0098802 ! plasma membrane signaling receptor complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0048180
name: activin complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0048183
name: activin AB complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
synonym: "inhibin beta-A" NARROW []
synonym: "inhibin beta-B" NARROW []
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0048184
name: obsolete follistatin binding
namespace: molecular_function
def: "OBSOLETE. Binding to the peptide hormone follistatin." [GOC:jid, GOC:mah]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "follistatin binding" EXACT []
is_obsolete: true
replaced_by: GO:0017046

[Term]
id: GO:0048185
name: activin binding
namespace: molecular_function
def: "Binding to activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0048188
name: Set1C/COMPASS complex
namespace: cellular_component
def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]
synonym: "COMPASS complex" EXACT [GOC:vw]
synonym: "Set1/COMPASS complex" EXACT [GOC:mah]
synonym: "Set1C" EXACT [GOC:vw]
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0048189
name: Lid2 complex
namespace: cellular_component
def: "A protein complex involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid2, Ash2, Jmj3, Snt2, and Sdc1." [PMID:12488447]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0048190
name: wing disc dorsal/ventral pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
synonym: "wing disc dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "wing disc dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0007450 ! dorsal/ventral pattern formation, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0048191
name: obsolete peptide stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jid]
comment: This term was made obsolete because it represents a biological process.
synonym: "peptide stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050822

[Term]
id: GO:0048192
name: obsolete peptide antigen stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jid]
comment: This term was made obsolete because it represents a biological process.
synonym: "peptide antigen stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050823

[Term]
id: GO:0048193
name: Golgi vesicle transport
namespace: biological_process
def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
subset: goslim_yeast
synonym: "Golgi-derived vesicle transport" RELATED []
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0048194
name: Golgi vesicle budding
namespace: biological_process
def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle budding" NARROW []
synonym: "Golgi-derived vesicle budding" EXACT []
is_a: GO:0006900 ! vesicle budding from membrane
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048195
name: Golgi membrane priming complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "formation of dictyosome membrane priming complex" NARROW []
synonym: "formation of Golgi membrane priming complex" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0048200 ! Golgi transport vesicle coating

[Term]
id: GO:0048196
name: obsolete plant extracellular matrix
namespace: cellular_component
def: "OBSOLETE. The matrix external to the plant plasma membrane, composed of the cell wall and middle lamella." [GOC:jid, GOC:mtg_sensu, PMID:11351084, PMID:4327466]
comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell.
synonym: "middle lamella-containing extracellular matrix" RELATED [GOC:tb]
synonym: "plant extracellular matrix" EXACT []
is_obsolete: true

[Term]
id: GO:0048197
name: Golgi membrane coat protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome membrane binding by cytosolic coat proteins" NARROW []
synonym: "dictyosome membrane bud coat oligomerisation" NARROW []
synonym: "Golgi apparatus membrane coat protein complex assembly" EXACT []
synonym: "Golgi membrane bud coat oligomerisation" NARROW []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0048200 ! Golgi transport vesicle coating

[Term]
id: GO:0048198
name: Golgi vesicle bud deformation and release
namespace: biological_process
def: "The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle bud deformation" NARROW []
synonym: "Golgi-derived vesicle bud deformation and release" EXACT []
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0048194 ! Golgi vesicle budding

[Term]
id: GO:0048199
name: vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle targeting" NARROW []
synonym: "Golgi vesicle targeting" EXACT []
synonym: "vesicle targeting, to, from or within dictyosome" NARROW []
is_a: GO:0006903 ! vesicle targeting
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048200
name: Golgi transport vesicle coating
namespace: biological_process
def: "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome transport vesicle coating" NARROW []
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0048194 ! Golgi vesicle budding
relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048201
name: vesicle targeting, plasma membrane to endosome
namespace: biological_process
def: "The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "plasma membrane to endosome targeting" EXACT []
is_a: GO:0006903 ! vesicle targeting

[Term]
id: GO:0048202
name: clathrin coating of Golgi vesicle
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "clathrin coating of Golgi-derived vesicle" EXACT []
is_a: GO:0048200 ! Golgi transport vesicle coating
is_a: GO:0048268 ! clathrin coat assembly

[Term]
id: GO:0048203
name: vesicle targeting, trans-Golgi to endosome
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "trans-Golgi to endosome targeting" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0006895 ! Golgi to endosome transport

[Term]
id: GO:0048204
name: vesicle targeting, inter-Golgi cisterna
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "inter-Golgi cisterna targeting" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport

[Term]
id: GO:0048205
name: COPI coating of Golgi vesicle
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "COPI coating of Golgi-derived vesicle" EXACT []
synonym: "COPI vesicle coating" RELATED [GOC:br]
is_a: GO:0048200 ! Golgi transport vesicle coating
relationship: part_of GO:0035964 ! COPI-coated vesicle budding

[Term]
id: GO:0048206
name: vesicle targeting, cis-Golgi to rough endoplasmic reticulum
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "cis-Golgi to rough endoplasmic reticulum targeting" EXACT []
synonym: "cis-Golgi to rough ER targeting" EXACT []
synonym: "vesicle targeting, cis-Golgi to rough ER" EXACT []
is_a: GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
is_a: GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:0048207
name: vesicle targeting, rough ER to cis-Golgi
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "rough endoplasmic reticulum to cis-Golgi targeting" EXACT []
synonym: "rough ER to cis-Golgi targeting" EXACT []
synonym: "vesicle targeting, rough endoplasmic reticulum to cis-Golgi" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport

[Term]
id: GO:0048208
name: COPII vesicle coating
namespace: biological_process
def: "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]
synonym: "COPII coating of ER-derived vesicle" EXACT [GOC:tb]
synonym: "COPII vesicle coat assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0006901 ! vesicle coating
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0048207 ! vesicle targeting, rough ER to cis-Golgi
relationship: part_of GO:0090114 ! COPII-coated vesicle budding

[Term]
id: GO:0048209
name: regulation of vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "regulation of Golgi vesicle targeting" EXACT []
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048210
name: Golgi vesicle fusion to target membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle fusion to target membrane" NARROW []
synonym: "Golgi-derived vesicle fusion to target membrane" EXACT []
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048211
name: Golgi vesicle docking
namespace: biological_process
def: "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle docking to target membrane" NARROW []
synonym: "Golgi vesicle docking with target membrane" EXACT []
synonym: "Golgi vesicle to membrane docking" EXACT []
synonym: "Golgi-derived vesicle docking" EXACT []
is_a: GO:0048278 ! vesicle docking
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048212
name: Golgi vesicle uncoating
namespace: biological_process
def: "The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle coat depolymerization" NARROW []
synonym: "Golgi vesicle coat depolymerization" EXACT []
synonym: "Golgi vesicle coat protein depolymerization" EXACT []
synonym: "Golgi-derived vesicle uncoating" EXACT []
is_a: GO:0072319 ! vesicle uncoating
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048213
name: obsolete Golgi vesicle prefusion complex stabilization
namespace: biological_process
def: "OBSOLETE. The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233]
comment: The reason for obsoletion is that it is too specific and there is no evidence for a Golgi vesicle prefusion complex.
synonym: "dictyosome vesicle prefusion complex stabilisation" NARROW []
synonym: "Golgi vesicle prefusion complex assembly" EXACT []
synonym: "Golgi-derived vesicle prefusion complex stabilization" EXACT []
is_obsolete: true

[Term]
id: GO:0048214
name: regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
comment: Note that GTP-binding Rab proteins serve as regulators of vesicle targeting and fusion.
is_a: GO:0031338 ! regulation of vesicle fusion
relationship: regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048215
name: positive regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "activation of Golgi vesicle fusion to target membrane" NARROW []
synonym: "stimulation of Golgi vesicle fusion to target membrane" NARROW []
synonym: "up regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "up-regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "upregulation of Golgi vesicle fusion to target membrane" EXACT []
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane
relationship: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048216
name: negative regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "down regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "down-regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "downregulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "inhibition of Golgi vesicle fusion to target membrane" NARROW []
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane
relationship: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048217
name: pectic matrix
namespace: cellular_component
def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jid, PMID:11554482]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048219
name: inter-Golgi cisterna vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "inter-Golgi cisterna transport" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0048222
name: glycoprotein network
namespace: cellular_component
def: "An extracellular matrix part that consists of cross-linked glycoproteins." [GOC:mah, PMID:18508691, PMID:7048321]
synonym: "extensin" EXACT []
xref: Wikipedia:Extensin
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009530 ! primary cell wall

[Term]
id: GO:0048223
name: hemicellulose network
namespace: cellular_component
def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [DOI:10.1016/j.foodchem.2008.11.065, GOC:jid]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048224
name: lignin network
namespace: cellular_component
def: "An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens." [GOC:jid, GOC:mah, PMID:14503002, PMID:16662709]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048225
name: suberin network
namespace: cellular_component
def: "An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier." [GOC:jid, GOC:mah, PMID:18440267, PMID:7706282]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048226
name: Casparian strip
namespace: cellular_component
def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jid]
xref: Wikipedia:Casparian_strip
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048227
name: plasma membrane to endosome transport
namespace: biological_process
def: "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid]
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0048228
name: obsolete actin cortical patch distribution
namespace: biological_process
def: "OBSOLETE. Any process that establishes the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells." [GOC:jid]
comment: This term was made obsolete because its definition is very similar to that of its parent term, actin cortical patch localization (GO:0051666), but somewhat unclear, and not similar enough to merge the terms.
synonym: "actin cortical patch distribution" EXACT []
is_obsolete: true

[Term]
id: GO:0048229
name: gametophyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana." [GOC:jid, PO:0009004]
synonym: "gametogenesis" BROAD []
is_a: GO:0007275 ! multicellular organism development

[Term]
id: GO:0048232
name: male gamete generation
namespace: biological_process
def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0048235
name: pollen sperm cell differentiation
namespace: biological_process
alt_id: GO:0048234
def: "The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte." [CL:0000366, GOC:jid, GOC:mtg_sensu]
synonym: "male gamete generation" BROAD []
synonym: "male gametophyte sperm cell differentiation" EXACT []
synonym: "sperm cell differentiation" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048232 ! male gamete generation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0048236
name: plant-type sporogenesis
namespace: biological_process
def: "The formation of plant spores derived from the products of meiosis. The spore gives rise to gametophytes." [GOC:tb]
synonym: "plant spore formation" EXACT []
is_a: GO:0034293 ! sexual sporulation
is_a: GO:0048869 ! cellular developmental process
is_a: GO:0051321 ! meiotic cell cycle
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0048237
name: rough endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jid]
synonym: "RER lumen" EXACT []
synonym: "rough ER lumen" EXACT []
xref: NIF_Subcellular:sao1819509473
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0048238
name: smooth endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jid]
synonym: "SER lumen" EXACT []
synonym: "smooth ER lumen" EXACT []
xref: NIF_Subcellular:sao927884761
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0048239
name: negative regulation of DNA recombination at telomere
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:jid, PMID:9635193]
synonym: "down regulation of telomeric recombination at telomere" EXACT []
synonym: "down-regulation of telomeric recombination at telomere" EXACT []
synonym: "downregulation of telomeric recombination at telomere" EXACT []
synonym: "inhibition of telomeric recombination at telomere" NARROW []
synonym: "negative regulation of telomeric recombination at telomere" EXACT [GOC:tb]
synonym: "suppression of telomeric recombination at telomere" EXACT []
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0072695 ! regulation of DNA recombination at telomere

[Term]
id: GO:0048240
name: sperm capacitation
namespace: biological_process
def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]
comment: Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract.
synonym: "sperm activation" RELATED [PMID:23180860]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0048241
name: epinephrine transport
namespace: biological_process
def: "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jid]
synonym: "adrenaline transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0048242
name: epinephrine secretion
namespace: biological_process
def: "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jid]
synonym: "adrenaline secretion" EXACT []
is_a: GO:0048241 ! epinephrine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048243
name: norepinephrine secretion
namespace: biological_process
def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid]
synonym: "noradrenaline secretion" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0023061 ! signal release
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048244
name: phytanoyl-CoA dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate." [EC:1.14.11.18, RHEA:16065]
synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.18]
synonym: "phytanoyl-CoA 2-hydroxylase activity" RELATED [EC:1.14.11.18]
synonym: "phytanoyl-CoA alpha-hydroxylase activity" RELATED [EC:1.14.11.18]
synonym: "phytanoyl-CoA hydroxylase activity" RELATED [EC:1.14.11.18]
synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.11.18]
xref: EC:1.14.11.18
xref: KEGG_REACTION:R05722
xref: MetaCyc:1.14.11.18-RXN
xref: Reactome:R-HSA-389639 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2"
xref: RHEA:16065
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0048245
name: eosinophil chemotaxis
namespace: biological_process
def: "The movement of an eosinophil in response to an external stimulus." [GOC:jid, PMID:11292027, PMID:12391252]
is_a: GO:0071621 ! granulocyte chemotaxis
is_a: GO:0072677 ! eosinophil migration

[Term]
id: GO:0048246
name: macrophage chemotaxis
namespace: biological_process
def: "The movement of a macrophage in response to an external stimulus." [GOC:jid]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:1905517 ! macrophage migration

[Term]
id: GO:0048247
name: lymphocyte chemotaxis
namespace: biological_process
def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0072676 ! lymphocyte migration

[Term]
id: GO:0048248
name: CXCR3 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CXCR3 chemokine receptor." [GOC:jid, PMID:10556837]
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0048249
name: high-affinity phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jid, PMID:8709965]
synonym: "high affinity phosphate transmembrane transporter activity" EXACT []
is_a: GO:0005315 ! phosphate transmembrane transporter activity

[Term]
id: GO:0048250
name: iron import into the mitochondrion
namespace: biological_process
alt_id: GO:1990925
def: "The process in which iron is transported from the cytosol into the mitochondrial matrix." [GOC:jid, PMID:12006577]
synonym: "mitochondrial iron cation transmembrane transport" EXACT []
synonym: "mitochondrial iron ion transmembrane transport" RELATED []
synonym: "mitochondrial iron ion transport" RELATED []
synonym: "mitochondrial iron transport" EXACT []
is_a: GO:0034755 ! iron ion transmembrane transport
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:0048251
name: elastic fiber assembly
namespace: biological_process
def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674]
synonym: "elastic fibre assembly" EXACT []
synonym: "elastin fiber assembly" EXACT [GOC:BHF]
synonym: "elastin fibre assembly" EXACT [GOC:BHF]
is_a: GO:0085029 ! extracellular matrix assembly
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0048252
name: lauric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [GOC:jid, PMID:15555597]
synonym: "lauric acid metabolism" EXACT []
synonym: "n-dodecanoic acid metabolic process" EXACT []
synonym: "n-dodecanoic acid metabolism" EXACT []
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0048254
name: snoRNA localization
namespace: biological_process
def: "Any process in which small nucleolar RNA is transported to, or maintained in, a specific location." [ISBN:0716731363]
synonym: "establishment and maintenance of snoRNA localization" EXACT []
synonym: "small nucleolar RNA localization" EXACT []
synonym: "snoRNA localisation" EXACT [GOC:mah]
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:0048255
name: mRNA stabilization
namespace: biological_process
def: "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]
is_a: GO:0043488 ! regulation of mRNA stability
is_a: GO:0043489 ! RNA stabilization
is_a: GO:1902373 ! negative regulation of mRNA catabolic process

[Term]
id: GO:0048256
name: flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid]
is_a: GO:0004520 ! DNA endonuclease activity

[Term]
id: GO:0048257
name: 3'-flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid, PMID:10635319]
synonym: "3' flap endonuclease activity" EXACT []
is_a: GO:0016889 ! DNA endonuclease activity, producing 3'-phosphomonoesters
is_a: GO:0048256 ! flap endonuclease activity

[Term]
id: GO:0048258
name: 3-ketoglucose-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN]
xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0048259
name: regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
synonym: "regulation of receptor mediated endocytosis" EXACT [GOC:tb]
is_a: GO:0030100 ! regulation of endocytosis
relationship: regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048260
name: positive regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
synonym: "activation of receptor mediated endocytosis" NARROW []
synonym: "positive regulation of receptor mediated endocytosis" EXACT [GOC:tb]
synonym: "stimulation of receptor mediated endocytosis" NARROW []
synonym: "up regulation of receptor mediated endocytosis" EXACT []
synonym: "up-regulation of receptor mediated endocytosis" EXACT []
synonym: "upregulation of receptor mediated endocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
relationship: positively_regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048261
name: negative regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators]
synonym: "down regulation of receptor mediated endocytosis" EXACT []
synonym: "down-regulation of receptor mediated endocytosis" EXACT []
synonym: "downregulation of receptor mediated endocytosis" EXACT []
synonym: "inhibition of receptor mediated endocytosis" NARROW []
synonym: "negative regulation of receptor mediated endocytosis" EXACT []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
relationship: negatively_regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048262
name: determination of dorsal/ventral asymmetry
namespace: biological_process
def: "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jid]
synonym: "determination of adaxial/abaxial asymmetry" RELATED [GOC:dph, GOC:tb]
synonym: "determination of dorsal-ventral asymmetry" EXACT [GOC:mah]
synonym: "determination of dorsoventral asymmetry" EXACT [GOC:mah]
is_a: GO:0009855 ! determination of bilateral symmetry
relationship: part_of GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0048263
name: determination of dorsal identity
namespace: biological_process
def: "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:jid]
synonym: "determination of adaxial identity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry

[Term]
id: GO:0048264
name: determination of ventral identity
namespace: biological_process
def: "The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph, GOC:isa_complete, GOC:jid]
synonym: "determination of abaxial identity" EXACT []
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry

[Term]
id: GO:0048265
name: response to pain
namespace: biological_process
alt_id: GO:0048267
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]
synonym: "physiological response to pain" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0048266
name: behavioral response to pain
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid]
synonym: "behavioural response to pain" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0048265 ! response to pain

[Term]
id: GO:0048268
name: clathrin coat assembly
namespace: biological_process
def: "The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]
synonym: "clathrin cage assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0048269
name: methionine adenosyltransferase complex
namespace: cellular_component
def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [GOC:jid, PMID:10644686, PMID:25075345]
synonym: "MAT complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0048270
name: methionine adenosyltransferase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of methionine adenosyltransferase." [GOC:jid, PMID:10644686]
comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'.
synonym: "MAT regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0048273
name: mitogen-activated protein kinase p38 binding
namespace: molecular_function
def: "Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [GOC:curators, PMID:17827184]
synonym: "MAPK p38 binding" EXACT []
is_a: GO:0051019 ! mitogen-activated protein kinase binding

[Term]
id: GO:0048275
name: obsolete N-terminal peptidyl-arginine acetylation
namespace: biological_process
def: "OBSOLETE. The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase." [GOC:jsg, PMID:12883043, RESID:AA0354]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0048277
name: obsolete nonexocytotic vesicle docking
namespace: biological_process
def: "OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process." [GOC:jid]
comment: This term was made obsolete because it violates the principle of positivity.
synonym: "non-exocytotic vesicle docking" EXACT []
synonym: "nonexocytotic vesicle docking" EXACT []
is_obsolete: true
replaced_by: GO:0048278

[Term]
id: GO:0048278
name: vesicle docking
namespace: biological_process
def: "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]
synonym: "vesicle to membrane docking" EXACT []
is_a: GO:0140056 ! organelle localization by membrane tethering
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0048279
name: vesicle fusion with endoplasmic reticulum
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum." [GOC:jid]
synonym: "vesicle fusion with ER" EXACT []
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0048280
name: vesicle fusion with Golgi apparatus
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0007030 ! Golgi organization
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048281
name: inflorescence morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010016 ! shoot system morphogenesis
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0010229 ! inflorescence development

[Term]
id: GO:0048282
name: determinate inflorescence morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems." [GOC:jid, PMID:9553044]
is_a: GO:0048281 ! inflorescence morphogenesis

[Term]
id: GO:0048283
name: indeterminate inflorescence morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems." [GOC:jid]
is_a: GO:0048281 ! inflorescence morphogenesis

[Term]
id: GO:0048284
name: organelle fusion
namespace: biological_process
def: "The creation of a single organelle from two or more organelles." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048285
name: organelle fission
namespace: biological_process
def: "The creation of two or more organelles by division of one organelle." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048286
name: lung alveolus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [GOC:mtg_lung, PMID:9751757]
synonym: "alveolarization" EXACT [PMID:17911382]
synonym: "alveologenesis" EXACT [GOC:17911382]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0048288
name: nuclear membrane fusion involved in karyogamy
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid]
synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000740 ! nuclear membrane fusion
relationship: part_of GO:0000741 ! karyogamy

[Term]
id: GO:0048289
name: isotype switching to IgE isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switch recombination to IgE isotypes" EXACT []
synonym: "class switching to IgE isotypes" EXACT []
synonym: "isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048290
name: isotype switching to IgA isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switching to IgA isotypes" EXACT []
synonym: "isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048291
name: isotype switching to IgG isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switching to IgG isotypes" EXACT []
synonym: "isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048292
name: isotype switching to IgD isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
comment: Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms.
synonym: "class switching to IgD isotypes" EXACT []
synonym: "isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048293
name: regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "regulation of class switching to IgE isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048294
name: negative regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgE isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgE isotypes" EXACT []
synonym: "downregulation of isotype switching to IgE isotypes" EXACT []
synonym: "inhibition of isotype switching to IgE isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "negative regulation of class switching to IgE isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
relationship: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048295
name: positive regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgE isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "positive regulation of class switching to IgE isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT []
synonym: "stimulation of isotype switching to IgE isotypes" NARROW []
synonym: "up regulation of isotype switching to IgE isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgE isotypes" EXACT []
synonym: "upregulation of isotype switching to IgE isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
relationship: positively_regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048296
name: regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "regulation of class switching to IgA isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048297
name: negative regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgA isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgA isotypes" EXACT []
synonym: "downregulation of isotype switching to IgA isotypes" EXACT []
synonym: "inhibition of isotype switching to IgA isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "negative regulation of class switching to IgA isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes
relationship: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048298
name: positive regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgA isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "positive regulation of class switching to IgA isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgA isotypes" EXACT []
synonym: "stimulation of isotype switching to IgA isotypes" NARROW []
synonym: "up regulation of isotype switching to IgA isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgA isotypes" EXACT []
synonym: "upregulation of isotype switching to IgA isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes
relationship: positively_regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048299
name: regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "regulation of class switching to IgD isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048300
name: negative regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgD isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgD isotypes" EXACT []
synonym: "downregulation of isotype switching to IgD isotypes" EXACT []
synonym: "inhibition of isotype switching to IgD isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "negative regulation of class switching to IgD isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes
relationship: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048301
name: positive regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgD isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "positive regulation of class switching to IgD isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgD isotypes" EXACT []
synonym: "stimulation of isotype switching to IgD isotypes" NARROW []
synonym: "up regulation of isotype switching to IgD isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgD isotypes" EXACT []
synonym: "upregulation of isotype switching to IgD isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes
relationship: positively_regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048302
name: regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "regulation of class switching to IgG isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048303
name: negative regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgG isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgG isotypes" EXACT []
synonym: "downregulation of isotype switching to IgG isotypes" EXACT []
synonym: "inhibition of isotype switching to IgG isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "negative regulation of class switching to IgG isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes
relationship: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048304
name: positive regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgG isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "positive regulation of class switching to IgG isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgG isotypes" EXACT []
synonym: "stimulation of isotype switching to IgG isotypes" NARROW []
synonym: "up regulation of isotype switching to IgG isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgG isotypes" EXACT []
synonym: "upregulation of isotype switching to IgG isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes
relationship: positively_regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048306
name: calcium-dependent protein binding
namespace: molecular_function
def: "Binding to a protein or protein complex in the presence of calcium." [GOC:jid, PMID:10485905]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0048307
name: ferredoxin-nitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + NH4+ + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H+ + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]." [RHEA:18041]
synonym: "ammonia:ferredoxin oxidoreductase activity" RELATED [EC:1.7.7.1]
xref: EC:1.7.7.1
xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN
xref: RHEA:18041
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0048308
name: organelle inheritance
namespace: biological_process
def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048309
name: endoplasmic reticulum inheritance
namespace: biological_process
def: "The partitioning of endoplasmic reticulum between daughter cells at cell division." [GOC:jid]
synonym: "ER inheritance" EXACT []
is_a: GO:0007029 ! endoplasmic reticulum organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048310
name: obsolete nucleus inheritance
namespace: biological_process
def: "OBSOLETE. The partitioning of nuclei between daughter cells at cell division." [GOC:jid]
comment: This term was obsoleted because it was not clearly defined.
synonym: "cell nucleus inheritance" EXACT []
is_obsolete: true

[Term]
id: GO:0048311
name: mitochondrion distribution
namespace: biological_process
def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]
synonym: "distribution of mitochondria" EXACT []
synonym: "mitochondrial distribution" EXACT []
synonym: "positioning of mitochondria" RELATED []
is_a: GO:0051646 ! mitochondrion localization

[Term]
id: GO:0048312
name: intracellular distribution of mitochondria
namespace: biological_process
def: "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]
synonym: "mitochondria positioning within cell" EXACT []
synonym: "mitochondrion positioning within cell" EXACT []
is_a: GO:0048311 ! mitochondrion distribution

[Term]
id: GO:0048313
name: Golgi inheritance
namespace: biological_process
def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069]
synonym: "Golgi apparatus inheritance" EXACT []
synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi partitioning" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048314
name: embryo sac morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants." [GOC:jid, GOC:mtg_plant, PMID:12271029, PMID:25332875]
synonym: "female gametophyte morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0048315
name: conidium formation
namespace: biological_process
def: "The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, ISBN:0963117211, PMID:2524423, PMID:9529886]
synonym: "conidia biosynthesis" RELATED []
synonym: "conidia formation" EXACT []
is_a: GO:0030436 ! asexual sporulation
relationship: part_of GO:0061794 ! conidium development

[Term]
id: GO:0048316
name: seed development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GOC:jid, PO:0009010]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0048317
name: seed morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the seed are generated and organized." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0048318
name: axial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048319
name: axial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048318 ! axial mesoderm development

[Term]
id: GO:0048320
name: axial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048319 ! axial mesoderm morphogenesis

[Term]
id: GO:0048321
name: axial mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell." [GOC:dgh]
synonym: "axial mesoderm cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048320 ! axial mesoderm formation

[Term]
id: GO:0048322
name: axial mesodermal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become an axial mesoderm cell." [GOC:dgh]
synonym: "axial mesoderm cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048321 ! axial mesodermal cell differentiation

[Term]
id: GO:0048323
name: axial mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
synonym: "axial mesoderm cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment

[Term]
id: GO:0048324
name: regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048325
name: negative regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of axial mesodermal cell fate determination" EXACT []
synonym: "down-regulation of axial mesodermal cell fate determination" EXACT []
synonym: "downregulation of axial mesodermal cell fate determination" EXACT []
synonym: "inhibition of axial mesodermal cell fate determination" NARROW []
is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
relationship: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048326
name: positive regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of axial mesodermal cell fate determination" NARROW []
synonym: "stimulation of axial mesodermal cell fate determination" NARROW []
synonym: "up regulation of axial mesodermal cell fate determination" EXACT []
synonym: "up-regulation of axial mesodermal cell fate determination" EXACT []
synonym: "upregulation of axial mesodermal cell fate determination" EXACT []
is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
relationship: positively_regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048327
name: axial mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
synonym: "axial mesoderm cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment

[Term]
id: GO:0048328
name: regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048329
name: negative regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of axial mesodermal cell fate specification" EXACT []
synonym: "down-regulation of axial mesodermal cell fate specification" EXACT []
synonym: "downregulation of axial mesodermal cell fate specification" EXACT []
synonym: "inhibition of axial mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification
relationship: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048330
name: positive regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of axial mesodermal cell fate specification" NARROW []
synonym: "stimulation of axial mesodermal cell fate specification" NARROW []
synonym: "up regulation of axial mesodermal cell fate specification" EXACT []
synonym: "up-regulation of axial mesodermal cell fate specification" EXACT []
synonym: "upregulation of axial mesodermal cell fate specification" EXACT []
is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
relationship: positively_regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048331
name: axial mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "axial mesoderm structural organisation" EXACT []
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048319 ! axial mesoderm morphogenesis

[Term]
id: GO:0048332
name: mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048333
name: mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh]
synonym: "mesoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001707 ! mesoderm formation

[Term]
id: GO:0048334
name: regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
is_a: GO:1905933 ! regulation of cell fate determination
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048335
name: negative regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of mesodermal cell fate determination" EXACT []
synonym: "down-regulation of mesodermal cell fate determination" EXACT []
synonym: "downregulation of mesodermal cell fate determination" EXACT []
synonym: "inhibition of mesodermal cell fate determination" NARROW []
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
is_a: GO:1905934 ! negative regulation of cell fate determination
relationship: negatively_regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048336
name: positive regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of mesodermal cell fate determination" NARROW []
synonym: "stimulation of mesodermal cell fate determination" NARROW []
synonym: "up regulation of mesodermal cell fate determination" EXACT []
synonym: "up-regulation of mesodermal cell fate determination" EXACT []
synonym: "upregulation of mesodermal cell fate determination" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
is_a: GO:1905935 ! positive regulation of cell fate determination
relationship: positively_regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048337
name: positive regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of mesodermal cell fate specification" NARROW []
synonym: "stimulation of mesodermal cell fate specification" NARROW []
synonym: "up regulation of mesodermal cell fate specification" EXACT []
synonym: "up-regulation of mesodermal cell fate specification" EXACT []
synonym: "upregulation of mesodermal cell fate specification" EXACT []
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
is_a: GO:1905772 ! positive regulation of mesodermal cell differentiation
relationship: positively_regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0048338
name: mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "mesoderm structural organisation" EXACT []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048332 ! mesoderm morphogenesis

[Term]
id: GO:0048339
name: paraxial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development

[Term]
id: GO:0048340
name: paraxial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0048339 ! paraxial mesoderm development

[Term]
id: GO:0048341
name: paraxial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis

[Term]
id: GO:0048342
name: paraxial mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell." [GOC:dgh]
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048341 ! paraxial mesoderm formation

[Term]
id: GO:0048343
name: paraxial mesodermal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a paraxial mesoderm cell." [GOC:dgh]
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048342 ! paraxial mesodermal cell differentiation

[Term]
id: GO:0048344
name: paraxial mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment

[Term]
id: GO:0048345
name: regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048346
name: positive regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of paraxial mesodermal cell fate determination" NARROW []
synonym: "stimulation of paraxial mesodermal cell fate determination" NARROW []
synonym: "up regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "up-regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "upregulation of paraxial mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination
relationship: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048347
name: negative regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "down-regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "downregulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "inhibition of paraxial mesodermal cell fate determination" NARROW []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination
relationship: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048348
name: paraxial mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment

[Term]
id: GO:0048349
name: regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048350
name: positive regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of paraxial mesodermal cell fate specification" NARROW []
synonym: "stimulation of paraxial mesodermal cell fate specification" NARROW []
synonym: "up regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "up-regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "upregulation of paraxial mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification
relationship: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048351
name: negative regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "down-regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "downregulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "inhibition of paraxial mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification
relationship: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048352
name: paraxial mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "paraxial mesoderm structural organisation" EXACT []
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis

[Term]
id: GO:0048353
name: primary endosperm nucleus
namespace: cellular_component
def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048354
name: mucilage biosynthetic process involved in seed coat development
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb]
synonym: "mucilage anabolism during seed coat development" EXACT []
synonym: "mucilage biosynthetic process during seed coat development" RELATED [GOC:dph, GOC:tb]
synonym: "mucilage formation during seed coat development" EXACT []
synonym: "mucilage synthesis during seed coat development" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
is_a: GO:0048359 ! mucilage metabolic process involved in seed coat development

[Term]
id: GO:0048355
name: root cap mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root cap mucilage anabolism" EXACT []
synonym: "root cap mucilage biosynthesis" EXACT []
synonym: "root cap mucilage formation" EXACT []
synonym: "root cap mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048360 ! root cap mucilage metabolic process

[Term]
id: GO:0048356
name: root epithelial mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root epithelial mucilage anabolism" EXACT []
synonym: "root epithelial mucilage biosynthesis" EXACT []
synonym: "root epithelial mucilage formation" EXACT []
synonym: "root epithelial mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048361 ! root epithelial mucilage metabolic process

[Term]
id: GO:0048357
name: pedicel mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem." [GOC:jid]
synonym: "pedicel mucilage anabolism" EXACT []
synonym: "pedicel mucilage biosynthesis" EXACT []
synonym: "pedicel mucilage formation" EXACT []
synonym: "pedicel mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048362 ! pedicel mucilage metabolic process

[Term]
id: GO:0048358
name: mucilage pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage." [GOC:jid]
synonym: "mucilage pectin anabolism" EXACT []
synonym: "mucilage pectin biosynthesis" EXACT []
synonym: "mucilage pectin formation" EXACT []
synonym: "mucilage pectin synthesis" EXACT []
is_a: GO:0045489 ! pectin biosynthetic process
is_a: GO:0048363 ! mucilage pectin metabolic process
relationship: part_of GO:0010192 ! mucilage biosynthetic process

[Term]
id: GO:0048359
name: mucilage metabolic process involved in seed coat development
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb]
synonym: "mucilage metabolic process during seed coat development" RELATED [GOC:dph, GOC:tb]
synonym: "mucilage metabolism during seed coat development" EXACT []
is_a: GO:0010191 ! mucilage metabolic process
relationship: part_of GO:0010214 ! seed coat development

[Term]
id: GO:0048360
name: root cap mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root cap mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048361
name: root epithelial mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root epithelial mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048362
name: pedicel mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the flower stem." [GOC:jid]
synonym: "pedicel mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048363
name: mucilage pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pectin component of mucilage." [GOC:jid]
synonym: "mucilage pectin metabolism" EXACT []
is_a: GO:0045488 ! pectin metabolic process
relationship: part_of GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048364
name: root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo." [GOC:jid, PO:0009005]
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0022622 ! root system development

[Term]
id: GO:0048366
name: leaf development
namespace: biological_process
def: "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048827 ! phyllome development

[Term]
id: GO:0048367
name: shoot system development
namespace: biological_process
alt_id: GO:0022621
def: "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "shoot development" EXACT []
is_a: GO:0048731 ! system development

[Term]
id: GO:0048368
name: lateral mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "lateral plate mesoderm development" EXACT []
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development

[Term]
id: GO:0048369
name: lateral mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators]
synonym: "lateral plate mesoderm morphogenesis" EXACT []
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0048368 ! lateral mesoderm development

[Term]
id: GO:0048370
name: lateral mesoderm formation
namespace: biological_process
def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid]
synonym: "lateral plate mesoderm biosynthesis" EXACT []
synonym: "lateral plate mesoderm formation" EXACT []
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis

[Term]
id: GO:0048371
name: lateral mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell." [GOC:jid]
synonym: "lateral mesoderm cell differentiation" EXACT []
synonym: "lateral plate mesoderm cell differentiation" EXACT []
synonym: "lateral plate mesodermal cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048370 ! lateral mesoderm formation

[Term]
id: GO:0048372
name: lateral mesodermal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a lateral mesoderm cell." [GOC:jid]
synonym: "lateral mesoderm cell fate commitment" EXACT []
synonym: "lateral plate mesoderm cell fate commitment" EXACT []
synonym: "lateral plate mesodermal cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048371 ! lateral mesodermal cell differentiation

[Term]
id: GO:0048373
name: lateral mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:jid]
synonym: "lateral mesoderm cell fate determination" EXACT []
synonym: "lateral plate mesoderm cell fate determination" EXACT []
synonym: "lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment

[Term]
id: GO:0048374
name: regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid]
synonym: "regulation of lateral mesoderm cell fate determination" EXACT []
synonym: "regulation of lateral plate mesoderm cell fate determination" EXACT []
synonym: "regulation of lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048375
name: negative regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid]
synonym: "down regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "down-regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "downregulation of lateral mesodermal cell fate determination" EXACT []
synonym: "inhibition of lateral mesodermal cell fate determination" NARROW []
synonym: "negative regulation of lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination
relationship: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048376
name: positive regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid]
synonym: "activation of lateral mesodermal cell fate determination" NARROW []
synonym: "positive regulation of lateral plate mesodermal cell fate determination" EXACT []
synonym: "stimulation of lateral mesodermal cell fate determination" NARROW []
synonym: "up regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "up-regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "upregulation of lateral mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination
relationship: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048377
name: lateral mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:jid]
synonym: "lateral mesoderm cell fate specification" EXACT []
synonym: "lateral plate mesoderm cell fate specification" EXACT []
synonym: "lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment

[Term]
id: GO:0048378
name: regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid]
synonym: "regulation of lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048379
name: positive regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid]
synonym: "activation of lateral mesodermal cell fate specification" NARROW []
synonym: "positive regulation of lateral plate mesodermal cell fate specification" EXACT []
synonym: "stimulation of lateral mesodermal cell fate specification" NARROW []
synonym: "up regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "up-regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "upregulation of lateral mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification
relationship: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048380
name: negative regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid]
synonym: "down regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "down-regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "downregulation of lateral mesodermal cell fate specification" EXACT []
synonym: "inhibition of lateral mesodermal cell fate specification" NARROW []
synonym: "negative regulation of lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification
relationship: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048381
name: lateral mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "lateral mesoderm structural organisation" EXACT []
synonym: "lateral plate mesoderm structural organization" EXACT []
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis

[Term]
id: GO:0048382
name: mesendoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues." [GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007492 ! endoderm development
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048383
name: mesectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues." [GOC:jid]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0007398 ! ectoderm development
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048384
name: retinoic acid receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a retinoic acid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:dgh]
synonym: "nuclear receptor-mediated retinoic acid signaling pathway" EXACT []
synonym: "RAR signaling pathway" EXACT []
synonym: "retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0141193 ! nuclear receptor-mediated signaling pathway

[Term]
id: GO:0048385
name: regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "regulation of RAR signaling pathway" EXACT []
synonym: "regulation of retinoic acid receptor signalling pathway" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048386
name: positive regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "activation of retinoic acid receptor signaling pathway" NARROW []
synonym: "positive regulation of RAR signaling pathway" EXACT []
synonym: "positive regulation of retinoic acid receptor signalling pathway" EXACT []
synonym: "stimulation of retinoic acid receptor signaling pathway" NARROW []
synonym: "up regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "up-regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "upregulation of retinoic acid receptor signaling pathway" EXACT []
is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048387
name: negative regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "down regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "down-regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "downregulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "inhibition of retinoic acid receptor signaling pathway" NARROW []
synonym: "negative regulation of RAR signaling pathway" EXACT []
synonym: "negative regulation of RAR signalling pathway" EXACT []
synonym: "negative regulation of retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048388
name: endosomal lumen acidification
namespace: biological_process
def: "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid]
is_a: GO:0051452 ! intracellular pH reduction
relationship: part_of GO:0007032 ! endosome organization

[Term]
id: GO:0048389
name: intermediate mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048390
name: intermediate mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048389 ! intermediate mesoderm development

[Term]
id: GO:0048391
name: intermediate mesoderm formation
namespace: biological_process
def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis

[Term]
id: GO:0048392
name: intermediate mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell." [GOC:dgh]
synonym: "intermediate mesoderm cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048391 ! intermediate mesoderm formation

[Term]
id: GO:0048393
name: intermediate mesodermal cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell." [GOC:dgh]
synonym: "intermediate mesoderm cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048392 ! intermediate mesodermal cell differentiation

[Term]
id: GO:0048394
name: intermediate mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
synonym: "intermediate mesoderm cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment

[Term]
id: GO:0048395
name: regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048396
name: negative regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "down-regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "downregulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "inhibition of intermediate mesodermal cell fate determination" NARROW []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination
relationship: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048397
name: positive regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of intermediate mesodermal cell fate determination" NARROW []
synonym: "stimulation of intermediate mesodermal cell fate determination" NARROW []
synonym: "up regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "up-regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "upregulation of intermediate mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination
relationship: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048398
name: intermediate mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
synonym: "intermediate mesoderm cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment

[Term]
id: GO:0048399
name: regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048400
name: positive regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of intermediate mesodermal cell fate specification" NARROW []
synonym: "stimulation of intermediate mesodermal cell fate specification" NARROW []
synonym: "up regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "up-regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "upregulation of intermediate mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification
relationship: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048401
name: negative regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "down-regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "downregulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "inhibition of intermediate mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification
relationship: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048402
name: intermediate mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "intermediate mesoderm structural organisation" EXACT []
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis

[Term]
id: GO:0048403
name: brain-derived neurotrophic factor binding
namespace: molecular_function
def: "Binding to brain-derived neurotrophic factor." [GOC:dgh]
synonym: "BDNF binding" EXACT []
synonym: "neurotrophin TRKB receptor activity" RELATED []
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048406
name: nerve growth factor binding
namespace: molecular_function
def: "Binding to nerve growth factor (NGF)." [GOC:dgh]
synonym: "beta-nerve growth factor binding" EXACT [PR:000011194]
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "NGF binding" EXACT [PR:000011194]
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048407
name: platelet-derived growth factor binding
namespace: molecular_function
def: "Binding to platelet-derived growth factor." [GOC:dgh]
synonym: "PDGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0048408
name: epidermal growth factor binding
namespace: molecular_function
def: "Binding to epidermal growth factor." [GOC:dgh]
synonym: "EGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0048437
name: floral organ development
namespace: biological_process
alt_id: GO:0048433
def: "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure." [GOC:go_curators, GOC:PO_curators, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048438
name: floral whorl development
namespace: biological_process
alt_id: GO:0048413
def: "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant." [GOC:dph, GOC:go_curators, GOC:PO_curators, GOC:tb, PO:0025023]
comment: Consider instead annotating to one of the more specific child terms, or to 'floral organ development ; GO:0048438' or one of its child terms.
synonym: "collective phyllome structure development" BROAD [GOC:PO_curators, PO:0025023]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048439
name: flower morphogenesis
namespace: biological_process
alt_id: GO:0048411
def: "The process in which the anatomical structures of the flower are generated and organized." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010016 ! shoot system morphogenesis
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048440
name: carpel development
namespace: biological_process
alt_id: GO:0048429
def: "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048467 ! gynoecium development

[Term]
id: GO:0048441
name: petal development
namespace: biological_process
alt_id: GO:0048417
def: "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048465 ! corolla development

[Term]
id: GO:0048442
name: sepal development
namespace: biological_process
alt_id: GO:0048421
def: "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048464 ! flower calyx development

[Term]
id: GO:0048443
name: stamen development
namespace: biological_process
alt_id: GO:0048425
def: "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048466 ! androecium development

[Term]
id: GO:0048444
name: floral organ morphogenesis
namespace: biological_process
alt_id: GO:0048434
def: "The process in which the anatomical structures of the floral organ are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090697 ! post-embryonic plant organ morphogenesis
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0048445
name: carpel morphogenesis
namespace: biological_process
alt_id: GO:0048430
def: "The process in which the anatomical structures of the carpel are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048446
name: petal morphogenesis
namespace: biological_process
alt_id: GO:0048418
def: "The process in which the anatomical structures of the petal are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048441 ! petal development

[Term]
id: GO:0048447
name: sepal morphogenesis
namespace: biological_process
alt_id: GO:0048422
def: "The process in which the anatomical structures of the sepal are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048442 ! sepal development

[Term]
id: GO:0048448
name: stamen morphogenesis
namespace: biological_process
alt_id: GO:0048426
def: "The process in which the anatomical structures of the stamen are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0048449
name: floral organ formation
namespace: biological_process
alt_id: GO:0048436
def: "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:1905393 ! plant organ formation
relationship: part_of GO:0048444 ! floral organ morphogenesis

[Term]
id: GO:0048450
name: floral organ structural organization
namespace: biological_process
alt_id: GO:0048435
def: "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025395]
synonym: "floral organ structural organisation" EXACT []
is_a: GO:0048444 ! floral organ morphogenesis
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048461 ! flower structural organization

[Term]
id: GO:0048451
name: petal formation
namespace: biological_process
alt_id: GO:0048419
def: "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048452
name: petal structural organization
namespace: biological_process
alt_id: GO:0048420
def: "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "petal structural organisation" EXACT []
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048453
name: sepal formation
namespace: biological_process
alt_id: GO:0048423
def: "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048447 ! sepal morphogenesis

[Term]
id: GO:0048454
name: sepal structural organization
namespace: biological_process
alt_id: GO:0048424
def: "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "sepal structural organisation" EXACT []
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048447 ! sepal morphogenesis

[Term]
id: GO:0048455
name: stamen formation
namespace: biological_process
alt_id: GO:0048427
def: "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048448 ! stamen morphogenesis

[Term]
id: GO:0048456
name: stamen structural organization
namespace: biological_process
alt_id: GO:0048428
def: "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "stamen structural organisation" EXACT []
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048448 ! stamen morphogenesis

[Term]
id: GO:0048457
name: floral whorl morphogenesis
namespace: biological_process
alt_id: GO:0048414
def: "The process in which the anatomical structures of the floral whorl are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025023]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0048438 ! floral whorl development
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048458
name: floral whorl formation
namespace: biological_process
alt_id: GO:0048415
def: "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025023]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048457 ! floral whorl morphogenesis

[Term]
id: GO:0048459
name: floral whorl structural organization
namespace: biological_process
alt_id: GO:0048416
def: "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025023]
synonym: "floral whorl structural organisation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048457 ! floral whorl morphogenesis
relationship: part_of GO:0048461 ! flower structural organization

[Term]
id: GO:0048460
name: flower formation
namespace: biological_process
alt_id: GO:0048410
def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048461
name: flower structural organization
namespace: biological_process
alt_id: GO:0048412
def: "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "flower structural organisation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048462
name: carpel formation
namespace: biological_process
alt_id: GO:0048431
def: "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048445 ! carpel morphogenesis

[Term]
id: GO:0048463
name: carpel structural organization
namespace: biological_process
alt_id: GO:0048432
def: "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "carpel structural organisation" EXACT []
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048445 ! carpel morphogenesis

[Term]
id: GO:0048464
name: flower calyx development
namespace: biological_process
def: "The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048465
name: corolla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048466
name: androecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048467
name: gynoecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower." [GOC:go_curators, PO:0008062]
synonym: "pistil development" EXACT []
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048468
name: cell development
namespace: biological_process
def: "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]
subset: goslim_candida
synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0048469
name: cell maturation
namespace: biological_process
def: "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators]
subset: goslim_pir
synonym: "functional differentiation" RELATED [GOC:dph]
is_a: GO:0048869 ! cellular developmental process
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0048471
name: perinuclear region of cytoplasm
namespace: cellular_component
def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0048472
name: threonine-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2." [EC:4.1.1.81, RHEA:11492]
synonym: "CobD" RELATED [EC:4.1.1.81]
synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81]
synonym: "L-threonine O-3-phosphate carboxy-lyase activity" RELATED [EC:4.1.1.81]
synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT []
xref: EC:4.1.1.81
xref: KEGG_REACTION:R06530
xref: MetaCyc:4.1.1.81-RXN
xref: RHEA:11492
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0048473
name: D-methionine transmembrane transport
namespace: biological_process
def: "The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:mlg, PMID:12169620]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015821 ! methionine transport
is_a: GO:0042940 ! D-amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0048475
name: coated membrane
namespace: cellular_component
def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid]
is_a: GO:0016020 ! membrane

[Term]
id: GO:0048476
name: Holliday junction resolvase complex
namespace: cellular_component
def: "An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated." [PMID:11207366, PMID:12374758]
subset: goslim_pir
synonym: "Mus81-Eme1 complex" NARROW []
synonym: "Mus81-Eme1 holliday resolvase complex" NARROW []
synonym: "Mus81-Eme2 complex" NARROW []
synonym: "Mus81-Eme2 holliday resolvase complex" NARROW []
synonym: "resolvasome" EXACT [PMID:11207366]
is_a: GO:1905347 ! endodeoxyribonuclease complex

[Term]
id: GO:0048477
name: oogenesis
namespace: biological_process
alt_id: GO:0009993
alt_id: GO:0048157
def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
synonym: "ovum development" EXACT systematic_synonym []
xref: Wikipedia:Oogenesis
is_a: GO:0007281 ! germ cell development
is_a: GO:0007292 ! female gamete generation

[Term]
id: GO:0048478
name: obsolete replication fork protection
namespace: biological_process
def: "OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]
comment: This term is obsoleted because it represents a phenotype and was unclearly defined.
synonym: "replication fork maintenance" BROAD []
synonym: "replication fork stabilization" BROAD []
is_obsolete: true
consider: GO:0031297

[Term]
id: GO:0048479
name: style development
namespace: biological_process
def: "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma." [GOC:jid, PO:0009074]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048480
name: stigma development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky." [GOC:jid, PO:0009073]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048481
name: plant ovule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0035670 ! plant-type ovary development

[Term]
id: GO:0048482
name: plant ovule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090698 ! post-embryonic plant morphogenesis
is_a: GO:1905392 ! plant organ morphogenesis
relationship: part_of GO:0048445 ! carpel morphogenesis
relationship: part_of GO:0048481 ! plant ovule development

[Term]
id: GO:0048483
name: autonomic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0048484
name: enteric nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [FMA:66070, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048485
name: sympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048486
name: parasympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048487
name: beta-tubulin binding
namespace: molecular_function
def: "Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]
synonym: "beta tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0048488
name: synaptic vesicle endocytosis
namespace: biological_process
alt_id: GO:0008099
def: "A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]
subset: goslim_synapse
synonym: "synaptic vesicle retrieval" RELATED []
is_a: GO:0140238 ! presynaptic endocytosis
relationship: part_of GO:0036465 ! synaptic vesicle recycling

[Term]
id: GO:0048489
name: synaptic vesicle transport
namespace: biological_process
alt_id: GO:0016181
def: "The directed movement of synaptic vesicles." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]
subset: goslim_synapse
synonym: "synaptic vesicle fission" RELATED []
synonym: "synaptic vesicle fusion" RELATED []
synonym: "synaptic vesicle trafficking" RELATED [PMID:15217342]
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
is_a: GO:0051650 ! establishment of vesicle localization
is_a: GO:0097479 ! synaptic vesicle localization

[Term]
id: GO:0048490
name: anterograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg]
subset: goslim_synapse
synonym: "anterograde axonal transport of synaptic vesicle" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0099517 ! synaptic vesicle transport along microtubule

[Term]
id: GO:0048491
name: retrograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body." [GOC:jid, GOC:lmg, PMID:24762653]
subset: goslim_synapse
synonym: "retrograde axonal transport of synaptic vesicle" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0099517 ! synaptic vesicle transport along microtubule

[Term]
id: GO:0048492
name: ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg]
subset: goslim_pir
synonym: "RubisCO complex" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0048493
name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu]
synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT []
synonym: "ribulose bisphosphate carboxylase complex" BROAD []
synonym: "RubisCO complex" BROAD []
is_a: GO:0048494 ! chromatophore ribulose bisphosphate carboxylase complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0048494
name: chromatophore ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu]
synonym: "RubisCO complex" BROAD []
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0048495
name: Roundabout binding
namespace: molecular_function
def: "Binding to Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527]
synonym: "Roundabout receptor binding" RELATED []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0048496
name: maintenance of animal organ identity
namespace: biological_process
def: "The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0048497
name: maintenance of floral organ identity
namespace: biological_process
def: "The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:PO_curators, GOC:tair_curators, PMID:9090883, PO:0025395]
is_a: GO:0090700 ! maintenance of plant organ identity
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0048498
name: establishment of petal orientation
namespace: biological_process
def: "The process that determines the orientation of petals with reference to the central axis." [GOC:tb, PMID:10572040]
is_a: GO:0048559 ! establishment of floral organ orientation
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048499
name: synaptic vesicle membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]
synonym: "SLMV biogenesis" NARROW []
synonym: "synaptic vesicle membrane organisation" EXACT []
synonym: "synaptic vesicle membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0048500
name: signal recognition particle
namespace: cellular_component
def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
subset: goslim_metagenomics
subset: goslim_pir
xref: Wikipedia:Signal_recognition_particle
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0048501
name: signal recognition particle, plasma membrane targeting
namespace: cellular_component
def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu]
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0048502
name: ABC-type thiamine transporter activity
namespace: molecular_function
alt_id: GO:0015619
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H+ + phosphate + thiamine(in)." [PMID:12175925, PMID:9535878, RHEA:29811]
synonym: "ATP-dependent thiamine transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled thiamine transmembrane transporter activity" RELATED []
synonym: "thiamin pyrophosphate ABC transporter" EXACT []
synonym: "thiamin pyrophosphate porter activity" BROAD []
synonym: "thiamin pyrophosphate transporting ATPase activity" RELATED []
synonym: "thiamin-transporting ATPase activity" RELATED []
synonym: "thiamine ABC transporter" EXACT []
synonym: "thiamine pyrophosphate-transporting ATPase activity" RELATED []
synonym: "thiamine-transporting ATPase activity" RELATED []
synonym: "TPP transporting ATPase activity" RELATED []
xref: EC:7.6.2.15
xref: MetaCyc:ABC-32-RXN
xref: RHEA:29811
xref: TC:3.A.1.19.1
is_a: GO:0015234 ! thiamine transmembrane transporter activity
is_a: GO:0140394 ! ABC-type azole transporter activity

[Term]
id: GO:0048503
name: obsolete GPI anchor binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]
comment: This term was made obsolete because it has been widely, and incorrectly, used to annotate proteins that have GPI anchors covalently attached. A new term has been created that can be used to annotate gene products that interact non-covalently with GPI anchors.
synonym: "glycosylphosphatidylinositol binding" EXACT []
synonym: "GPI anchor binding" EXACT []
is_obsolete: true

[Term]
id: GO:0048504
name: regulation of timing of animal organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of animal organ formation at a consistent predetermined time point during development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb]
synonym: "timing of organ biosynthesis" RELATED []
synonym: "timing of organ formation" RELATED []
is_a: GO:0003156 ! regulation of animal organ formation
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0048505
name: regulation of timing of cell differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb]
synonym: "timing of cell differentiation" RELATED []
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0045595 ! regulation of cell differentiation

[Term]
id: GO:0048506
name: regulation of timing of meristematic phase transition
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point." [GOC:dph, GOC:jid, GOC:tb]
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0048509 ! regulation of meristem development

[Term]
id: GO:0048507
name: meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0048508
name: embryonic meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048507 ! meristem development
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0048509
name: regulation of meristem development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048507 ! meristem development

[Term]
id: GO:0048510
name: regulation of timing of transition from vegetative to reproductive phase
namespace: biological_process
def: "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs." [GOC:jid, PMID:8974397]
is_a: GO:0048506 ! regulation of timing of meristematic phase transition

[Term]
id: GO:0048511
name: rhythmic process
namespace: biological_process
def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]
subset: goslim_pir
synonym: "rhythm" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0048512
name: circadian behavior
namespace: biological_process
def: "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]
synonym: "circadian rhythm behavior" EXACT []
is_a: GO:0007622 ! rhythmic behavior
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0048513
name: animal organ development
namespace: biological_process
def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]
synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0048514
name: blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0048515
name: spermatid differentiation
namespace: biological_process
def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
synonym: "spermatid cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048516
name: obsolete trichome initiation (sensu Magnoliophyta)
namespace: biological_process
def: "OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "trichome initiation (sensu Magnoliophyta)" EXACT []
is_obsolete: true
consider: GO:0048629

[Term]
id: GO:0048517
name: obsolete positive regulation of trichome initiation (sensu Magnoliophyta)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "positive regulation of trichome initiation (sensu Magnoliophyta)" EXACT []
is_obsolete: true
consider: GO:0048629

[Term]
id: GO:0048518
name: positive regulation of biological process
namespace: biological_process
alt_id: GO:0043119
def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of biological process" NARROW []
synonym: "positive regulation of physiological process" EXACT []
synonym: "stimulation of biological process" NARROW []
synonym: "up regulation of biological process" EXACT []
synonym: "up-regulation of biological process" EXACT []
synonym: "upregulation of biological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: positively_regulates GO:0008150 ! biological_process

[Term]
id: GO:0048519
name: negative regulation of biological process
namespace: biological_process
alt_id: GO:0043118
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of biological process" EXACT []
synonym: "down-regulation of biological process" EXACT []
synonym: "downregulation of biological process" EXACT []
synonym: "inhibition of biological process" NARROW []
synonym: "negative regulation of physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: negatively_regulates GO:0008150 ! biological_process

[Term]
id: GO:0048520
name: positive regulation of behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "activation of behavior" NARROW []
synonym: "stimulation of behavior" NARROW []
synonym: "up regulation of behavior" EXACT []
synonym: "up-regulation of behavior" EXACT []
synonym: "upregulation of behavior" EXACT []
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048521
name: negative regulation of behavior
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "down regulation of behavior" EXACT []
synonym: "down-regulation of behavior" EXACT []
synonym: "downregulation of behavior" EXACT []
synonym: "inhibition of behavior" NARROW []
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048522
name: positive regulation of cellular process
namespace: biological_process
alt_id: GO:0051242
def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of cellular process" NARROW []
synonym: "positive regulation of cellular physiological process" EXACT []
synonym: "stimulation of cellular process" NARROW []
synonym: "up regulation of cellular process" EXACT []
synonym: "up-regulation of cellular process" EXACT []
synonym: "upregulation of cellular process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
relationship: positively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048523
name: negative regulation of cellular process
namespace: biological_process
alt_id: GO:0051243
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular process" EXACT []
synonym: "down-regulation of cellular process" EXACT []
synonym: "downregulation of cellular process" EXACT []
synonym: "inhibition of cellular process" NARROW []
synonym: "negative regulation of cellular physiological process" EXACT []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
relationship: negatively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048524
name: positive regulation of viral process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]
synonym: "activation of viral life cycle" NARROW []
synonym: "positive regulation of viral life cycle" NARROW [GOC:tb]
synonym: "positive regulation of viral reproduction" NARROW [GOC:bf, GOC:jl]
synonym: "stimulation of viral life cycle" NARROW []
synonym: "up regulation of viral life cycle" NARROW []
synonym: "up-regulation of viral life cycle" NARROW []
synonym: "upregulation of viral life cycle" NARROW []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050792 ! regulation of viral process
relationship: positively_regulates GO:0016032 ! viral process

[Term]
id: GO:0048525
name: negative regulation of viral process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]
synonym: "down regulation of viral life cycle" NARROW []
synonym: "down-regulation of viral life cycle" NARROW []
synonym: "downregulation of viral life cycle" NARROW []
synonym: "inhibition of viral life cycle" NARROW []
synonym: "negative regulation of viral life cycle" NARROW [GOC:tb]
synonym: "negative regulation of viral reproduction" NARROW [GOC:bf, GOC:jl]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050792 ! regulation of viral process
relationship: negatively_regulates GO:0016032 ! viral process

[Term]
id: GO:0048526
name: imaginal disc-derived wing expansion
namespace: biological_process
def: "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc]
synonym: "wing expansion" EXACT []
synonym: "wing inflation" EXACT []
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0048527
name: lateral root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tb]
is_a: GO:0048528 ! post-embryonic root development

[Term]
id: GO:0048528
name: post-embryonic root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0048364 ! root development
is_a: GO:0090696 ! post-embryonic plant organ development

[Term]
id: GO:0048529
name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81, RHEA:33235]
synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.13.81]
synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" RELATED [EC:1.14.13.81]
synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" RELATED [EC:1.14.13.81]
xref: EC:1.14.13.81
xref: RHEA:33235
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0048530
name: fruit morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant." [GOC:sm]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0048531
name: beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958]
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0048532
name: anatomical structure arrangement
namespace: biological_process
def: "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:go_curators]
synonym: "anatomical structure organization" BROAD []
synonym: "anatomical structure structural organization" EXACT []
synonym: "organization of an anatomical structure" EXACT []
synonym: "structural organization" EXACT []
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048533
name: sporocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores." [GOC:tair_curators]
synonym: "sporocyte development" NARROW []
synonym: "sporocyte morphogenesis" RELATED []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048534
name: hematopoietic or lymphoid organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]
synonym: "haematopoietic or lymphoid organ development" EXACT []
synonym: "haemopoietic or lymphoid organ development" EXACT []
synonym: "hemopoietic or lymphoid organ development" EXACT []
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0048535
name: lymph node development
namespace: biological_process
def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X, ISBN:0781735149]
synonym: "lymph gland development" BROAD []
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048536
name: spleen development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149]
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048537
name: mucosa-associated lymphoid tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149]
synonym: "BALT development" NARROW []
synonym: "bronchial-associated lymphoid tissue development" NARROW []
synonym: "GALT development" NARROW []
synonym: "gut-associated lymphoid tissue development" NARROW []
synonym: "mucosal-associated lymphoid tissue development" EXACT []
synonym: "NALT development" NARROW []
synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW []
is_a: GO:0009888 ! tissue development
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048538
name: thymus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149]
comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere.
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048539
name: bone marrow development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149]
is_a: GO:0009888 ! tissue development
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0048540
name: bursa of Fabricius development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation." [GOC:add, ISBN:0781735149]
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048541
name: Peyer's patch development
namespace: biological_process
def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149]
synonym: "GALT development" RELATED []
synonym: "gut-associated lymphoid tissue development" RELATED []
is_a: GO:0048537 ! mucosa-associated lymphoid tissue development

[Term]
id: GO:0048542
name: lymph gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
synonym: "haematopoietic organ development" BROAD []
synonym: "haemopoietic organ development" BROAD []
synonym: "hematopoietic organ development" BROAD []
synonym: "hemopoietic organ development" BROAD []
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048543
name: phytochrome chromophore biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form." [GOC:pj, PMID:2909515]
synonym: "phytochrome chromophore anabolism" EXACT []
synonym: "phytochrome chromophore biosynthesis" EXACT []
synonym: "phytochrome chromophore formation" EXACT []
synonym: "phytochrome chromophore synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0048544
name: recognition of pollen
namespace: biological_process
alt_id: GO:0009857
def: "A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma." [GOC:dph, GOC:pj, GOC:tb]
synonym: "pollen recognition" EXACT []
synonym: "recognition or rejection of self pollen" RELATED [GOC:dph, GOC:tb]
synonym: "self incompatibility" RELATED []
is_a: GO:0008037 ! cell recognition

[Term]
id: GO:0048545
name: response to steroid hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators]
synonym: "response to steroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0048546
name: digestive tract morphogenesis
namespace: biological_process
alt_id: GO:0048547
def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131]
synonym: "alimentary canal morphogenesis" EXACT []
synonym: "digestive tube morphogenesis" EXACT []
synonym: "gastrointestinal tract morphogenesis" EXACT []
synonym: "gut morphogenesis" BROAD [GOC:dph]
synonym: "intestinal morphogenesis" NARROW []
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0048548
name: regulation of pinocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
is_a: GO:0030100 ! regulation of endocytosis
relationship: regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048549
name: positive regulation of pinocytosis
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
synonym: "activation of pinocytosis" NARROW []
synonym: "stimulation of pinocytosis" NARROW []
synonym: "up regulation of pinocytosis" EXACT []
synonym: "up-regulation of pinocytosis" EXACT []
synonym: "upregulation of pinocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0048548 ! regulation of pinocytosis
relationship: positively_regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048550
name: negative regulation of pinocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
synonym: "down regulation of pinocytosis" EXACT []
synonym: "down-regulation of pinocytosis" EXACT []
synonym: "downregulation of pinocytosis" EXACT []
synonym: "inhibition of pinocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0048548 ! regulation of pinocytosis
relationship: negatively_regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048555
name: generative cell nucleus
namespace: cellular_component
def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators]
synonym: "male germ cell nucleus" BROAD []
synonym: "sperm cell nucleus" BROAD []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048556
name: microsporocyte nucleus
namespace: cellular_component
alt_id: GO:0043074
def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X]
synonym: "microspore mother cell nucleus" EXACT []
synonym: "pollen mother cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048557
name: embryonic digestive tract morphogenesis
namespace: biological_process
alt_id: GO:0048558
def: "The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
synonym: "embryonic gut morphogenesis" BROAD [GOC:dph]
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: part_of GO:0048566 ! embryonic digestive tract development

[Term]
id: GO:0048559
name: establishment of floral organ orientation
namespace: biological_process
def: "The process that determines the orientation of the floral organs with reference to the central axis of the flower." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090707 ! establishment of plant organ orientation
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048560
name: establishment of anatomical structure orientation
namespace: biological_process
def: "The process that determines the orientation of an anatomical structure with reference to an axis." [GOC:jid]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048561
name: establishment of animal organ orientation
namespace: biological_process
def: "The process that determines the orientation of an animal organ or tissue with reference to an axis." [GOC:jid]
is_a: GO:0048560 ! establishment of anatomical structure orientation
relationship: part_of GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0048562
name: embryonic organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048568 ! embryonic organ development

[Term]
id: GO:0048563
name: obsolete post-embryonic animal organ morphogenesis
namespace: biological_process
def: "OBSOLETE. Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
comment: This term is an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009887

[Term]
id: GO:0048564
name: photosystem I assembly
namespace: biological_process
alt_id: GO:0010251
def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane." [GOC:go_curators]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0048565
name: digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
synonym: "gut development" BROAD [GOC:dph]
synonym: "intestinal development" NARROW []
synonym: "intestine development" NARROW []
is_a: GO:0035295 ! tube development
relationship: part_of GO:0055123 ! digestive system development

[Term]
id: GO:0048566
name: embryonic digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators]
is_a: GO:0048565 ! digestive tract development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0048567
name: ectodermal digestive tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid]
synonym: "ectodermal gut morphogenesis" RELATED [GOC:dph]
is_a: GO:0007439 ! ectodermal digestive tract development
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0048568
name: embryonic organ development
namespace: biological_process
def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
synonym: "embryonic organogenesis" EXACT []
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0048569
name: obsolete post-embryonic animal organ development
namespace: biological_process
def: "OBSOLETE. Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
comment: This term is an unnecessary grouping term.
synonym: "post-embryonic animal organogenesis" EXACT []
is_obsolete: true
replaced_by: GO:0048513

[Term]
id: GO:0048570
name: notochord morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0030903 ! notochord development

[Term]
id: GO:0048571
name: long-day photoperiodism
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "response to long-day" EXACT []
synonym: "response to long-day photoperiod" RELATED []
synonym: "response to short-night" EXACT []
synonym: "short-night photoperiodism" EXACT []
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0048572
name: short-day photoperiodism
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-night photoperiodism" EXACT []
synonym: "response to long-night" EXACT []
synonym: "response to short-day" EXACT []
synonym: "response to short-day photoperiod" RELATED []
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0048573
name: photoperiodism, flowering
namespace: biological_process
def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "photoperiodic control of flowering time" EXACT []
synonym: "photoperiodic control of inflorescence development" EXACT []
synonym: "response to day length, flowering" EXACT []
synonym: "response to night length, flowering" EXACT []
synonym: "response to photoperiod, flowering" EXACT []
is_a: GO:0009648 ! photoperiodism
relationship: part_of GO:0010228 ! vegetative to reproductive phase transition of meristem

[Term]
id: GO:0048574
name: long-day photoperiodism, flowering
namespace: biological_process
def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-day photoperiodic control of flowering" EXACT []
synonym: "long-day photoperiodic control of flowering time" EXACT []
synonym: "long-day photoperiodic control of inflorescence development" EXACT []
synonym: "response to long-day, flowering" EXACT []
synonym: "response to short-night, flowering" EXACT []
synonym: "short-night photoperiodism, flowering" EXACT []
is_a: GO:0048571 ! long-day photoperiodism
is_a: GO:0048573 ! photoperiodism, flowering

[Term]
id: GO:0048575
name: short-day photoperiodism, flowering
namespace: biological_process
def: "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-night photoperiodism, flowering" EXACT []
synonym: "response to long-night, flowering" EXACT []
synonym: "response to short-day, flowering" EXACT []
synonym: "short-day photoperiodic control of flowering" EXACT []
synonym: "short-day photoperiodic control of flowering time" EXACT []
synonym: "short-day photoperiodic control of inflorescence development" EXACT []
is_a: GO:0048572 ! short-day photoperiodism
is_a: GO:0048573 ! photoperiodism, flowering

[Term]
id: GO:0048576
name: positive regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "activation of short-day photoperiodism, flowering" NARROW []
synonym: "stimulation of short-day photoperiodism, flowering" NARROW []
synonym: "up regulation of short-day photoperiodism, flowering" EXACT []
synonym: "up-regulation of short-day photoperiodism, flowering" EXACT []
synonym: "upregulation of short-day photoperiodism, flowering" EXACT []
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering
relationship: positively_regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048577
name: negative regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "down regulation of short-day photoperiodism, flowering" EXACT []
synonym: "down-regulation of short-day photoperiodism, flowering" EXACT []
synonym: "downregulation of short-day photoperiodism, flowering" EXACT []
synonym: "inhibition of short-day photoperiodism, flowering" NARROW []
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering
relationship: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048578
name: positive regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "activation of long-day photoperiodism, flowering" NARROW []
synonym: "stimulation of long-day photoperiodism, flowering" NARROW []
synonym: "up regulation of long-day photoperiodism, flowering" EXACT []
synonym: "up-regulation of long-day photoperiodism, flowering" EXACT []
synonym: "upregulation of long-day photoperiodism, flowering" EXACT []
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering
relationship: positively_regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048579
name: negative regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "down regulation of long-day photoperiodism, flowering" EXACT []
synonym: "down-regulation of long-day photoperiodism, flowering" EXACT []
synonym: "downregulation of long-day photoperiodism, flowering" EXACT []
synonym: "inhibition of long-day photoperiodism, flowering" NARROW []
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering
relationship: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048580
name: regulation of post-embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048581
name: negative regulation of post-embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "down regulation of post-embryonic development" EXACT []
synonym: "down-regulation of post-embryonic development" EXACT []
synonym: "downregulation of post-embryonic development" EXACT []
synonym: "inhibition of post-embryonic development" NARROW []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048582
name: positive regulation of post-embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "activation of post-embryonic development" NARROW []
synonym: "stimulation of post-embryonic development" NARROW []
synonym: "up regulation of post-embryonic development" EXACT []
synonym: "up-regulation of post-embryonic development" EXACT []
synonym: "upregulation of post-embryonic development" EXACT []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048583
name: regulation of response to stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048584
name: positive regulation of response to stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to stimulus" NARROW []
synonym: "stimulation of response to stimulus" NARROW []
synonym: "up regulation of response to stimulus" EXACT []
synonym: "up-regulation of response to stimulus" EXACT []
synonym: "upregulation of response to stimulus" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: positively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048585
name: negative regulation of response to stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to stimulus" EXACT []
synonym: "down-regulation of response to stimulus" EXACT []
synonym: "downregulation of response to stimulus" EXACT []
synonym: "inhibition of response to stimulus" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: negatively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048586
name: regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
is_a: GO:2000028 ! regulation of photoperiodism, flowering
relationship: regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048587
name: regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
is_a: GO:2000028 ! regulation of photoperiodism, flowering
relationship: regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048588
name: developmental cell growth
namespace: biological_process
def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]
subset: gocheck_do_not_annotate
synonym: "developmental growth of a unicellular organism" EXACT []
is_a: GO:0016049 ! cell growth
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0048589
name: developmental growth
namespace: biological_process
def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
is_a: GO:0040007 ! growth
relationship: part_of GO:0032502 ! developmental process

[Term]
id: GO:0048592
name: eye morphogenesis
namespace: biological_process
alt_id: GO:0048748
def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0001654 ! eye development

[Term]
id: GO:0048593
name: camera-type eye morphogenesis
namespace: biological_process
alt_id: GO:0048594
alt_id: GO:0048595
def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu]
synonym: "camera-style eye morphogenesis" EXACT [GOC:dph]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0048596
name: embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic eye morphogenesis" BROAD []
is_a: GO:0048048 ! embryonic eye morphogenesis
relationship: part_of GO:0031076 ! embryonic camera-type eye development
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0048597
name: post-embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized during post-embryonic development." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
synonym: "post-embryonic camera-style eye morphogenesis" EXACT []
synonym: "post-embryonic eye morphogenesis" BROAD []
is_a: GO:0048050 ! post-embryonic eye morphogenesis
relationship: part_of GO:0031077 ! post-embryonic camera-type eye development
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0048598
name: embryonic morphogenesis
namespace: biological_process
alt_id: GO:0048828
def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0048599
name: oocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]
is_a: GO:0007281 ! germ cell development
relationship: part_of GO:0009994 ! oocyte differentiation

[Term]
id: GO:0048600
name: oocyte fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0009994 ! oocyte differentiation

[Term]
id: GO:0048601
name: oocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
synonym: "oocyte morphogenesis during differentiation" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0048608
name: reproductive structure development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061458 ! reproductive system development

[Term]
id: GO:0048609
name: multicellular organismal reproductive process
namespace: biological_process
def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
synonym: "organismal reproductive process" BROAD []
synonym: "reproductive process in a multicellular organism" EXACT []
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0048610
name: obsolete cellular process involved in reproduction
namespace: biological_process
def: "OBSOLETE. A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism." [GOC:dph, GOC:jid]
comment: This process was made obsolete because we felt it not provide a particularly useful classification, and its very broad logical definition caused regular problems in our inference pipelines.
synonym: "cellular process involved in reproduction" EXACT []
synonym: "reproductive cellular process" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0048611
name: embryonic ectodermal digestive tract development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc]
synonym: "embryonic ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0048566 ! embryonic digestive tract development
relationship: part_of GO:0007439 ! ectodermal digestive tract development

[Term]
id: GO:0048612
name: post-embryonic ectodermal digestive tract development
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc]
synonym: "post-embryonic ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0007439 ! ectodermal digestive tract development

[Term]
id: GO:0048613
name: embryonic ectodermal digestive tract morphogenesis
namespace: biological_process
def: "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized." [GOC:jid, GOC:rc]
synonym: "embryonic ectodermal gut morphogenesis" RELATED [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048557 ! embryonic digestive tract morphogenesis
relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis
relationship: part_of GO:0048611 ! embryonic ectodermal digestive tract development

[Term]
id: GO:0048614
name: post-embryonic ectodermal digestive tract morphogenesis
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized." [GOC:jid, GOC:rc]
synonym: "post-embryonic ectodermal gut morphogenesis" RELATED [GOC:dph]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis
relationship: part_of GO:0048612 ! post-embryonic ectodermal digestive tract development
relationship: part_of GO:0048621 ! post-embryonic digestive tract morphogenesis

[Term]
id: GO:0048615
name: embryonic anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis
relationship: part_of GO:0048613 ! embryonic ectodermal digestive tract morphogenesis

[Term]
id: GO:0048616
name: post-embryonic anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis
relationship: part_of GO:0048614 ! post-embryonic ectodermal digestive tract morphogenesis

[Term]
id: GO:0048617
name: embryonic foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007440 ! foregut morphogenesis

[Term]
id: GO:0048618
name: post-embryonic foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007440 ! foregut morphogenesis

[Term]
id: GO:0048619
name: embryonic hindgut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007442 ! hindgut morphogenesis

[Term]
id: GO:0048620
name: post-embryonic hindgut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007442 ! hindgut morphogenesis

[Term]
id: GO:0048621
name: post-embryonic digestive tract morphogenesis
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:jid, GOC:rc]
synonym: "post-embryonic gut morphogenesis" BROAD [GOC:dph]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0048622
name: obsolete reproductive sporulation
namespace: biological_process
def: "OBSOLETE. The formation of reproductive spores." [GOC:jid]
comment: This term was made obsolete because it was ambiguously defined and incorrectly placed in the ontology.
synonym: "reproductive sporulation" EXACT []
is_obsolete: true

[Term]
id: GO:0048623
name: seed germination on parent plant
namespace: biological_process
def: "The process in which a seed germinates before being shed from the parent plant." [GOC:go_curators]
synonym: "non-vegetative vivipary" BROAD []
synonym: "pre-harvest sprouting" EXACT []
synonym: "vivipary" BROAD []
is_a: GO:0009845 ! seed germination

[Term]
id: GO:0048624
name: plantlet formation on parent plant
namespace: biological_process
def: "The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed." [GOC:go_curators]
synonym: "vegetative vivipary" BROAD []
synonym: "vivipary" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048507 ! meristem development
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0048625
name: myoblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0045445 ! myoblast differentiation

[Term]
id: GO:0048626
name: myoblast fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0048627
name: myoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0045445 ! myoblast differentiation

[Term]
id: GO:0048628
name: myoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048627 ! myoblast development

[Term]
id: GO:0048629
name: trichome patterning
namespace: biological_process
def: "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes." [GOC:jid, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181]
synonym: "trichome distribution" BROAD []
synonym: "trichome pattern biosynthesis" EXACT []
synonym: "trichome pattern formation" EXACT []
synonym: "trichome pattern specification" RELATED []
synonym: "trichome spacing" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment
relationship: part_of GO:0010026 ! trichome differentiation

[Term]
id: GO:0048630
name: skeletal muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048631
name: regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048632
name: negative regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "down regulation of skeletal muscle growth" EXACT []
synonym: "down-regulation of skeletal muscle growth" EXACT []
synonym: "downregulation of skeletal muscle growth" EXACT []
synonym: "inhibition of skeletal muscle growth" NARROW []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048640 ! negative regulation of developmental growth
relationship: negatively_regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048633
name: positive regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "activation of skeletal muscle growth" NARROW []
synonym: "stimulation of skeletal muscle growth" NARROW []
synonym: "up regulation of skeletal muscle growth" EXACT []
synonym: "up-regulation of skeletal muscle growth" EXACT []
synonym: "upregulation of skeletal muscle growth" EXACT []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048634
name: regulation of muscle organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048635
name: negative regulation of muscle organ development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators]
synonym: "down regulation of muscle development" EXACT []
synonym: "down-regulation of muscle development" EXACT []
synonym: "downregulation of muscle development" EXACT []
synonym: "inhibition of muscle development" NARROW []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048636
name: positive regulation of muscle organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
synonym: "activation of muscle development" NARROW []
synonym: "stimulation of muscle development" NARROW []
synonym: "up regulation of muscle development" EXACT []
synonym: "up-regulation of muscle development" EXACT []
synonym: "upregulation of muscle development" EXACT []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048638
name: regulation of developmental growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048639
name: positive regulation of developmental growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators]
synonym: "activation of developmental growth" NARROW []
synonym: "stimulation of developmental growth" NARROW []
synonym: "up regulation of developmental growth" EXACT []
synonym: "up-regulation of developmental growth" EXACT []
synonym: "upregulation of developmental growth" EXACT []
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048640
name: negative regulation of developmental growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators]
synonym: "down regulation of developmental growth" EXACT []
synonym: "down-regulation of developmental growth" EXACT []
synonym: "downregulation of developmental growth" EXACT []
synonym: "inhibition of developmental growth" NARROW []
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048641
name: regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
is_a: GO:0016202 ! regulation of striated muscle tissue development
relationship: regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048642
name: negative regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
synonym: "down regulation of skeletal muscle development" EXACT []
synonym: "down-regulation of skeletal muscle development" EXACT []
synonym: "downregulation of skeletal muscle development" EXACT []
synonym: "inhibition of skeletal muscle development" NARROW []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: negatively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048643
name: positive regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators]
synonym: "activation of skeletal muscle development" NARROW []
synonym: "stimulation of skeletal muscle development" NARROW []
synonym: "up regulation of skeletal muscle development" EXACT []
synonym: "up-regulation of skeletal muscle development" EXACT []
synonym: "upregulation of skeletal muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048644
name: muscle organ morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0007517 ! muscle organ development

[Term]
id: GO:0048645
name: animal organ formation
namespace: biological_process
def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid]
synonym: "animal organ primordium initiation" NARROW []
synonym: "initiation of an animal organ primordium" NARROW []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0048646
name: anatomical structure formation involved in morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]
comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.
subset: goslim_chembl
synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048647
name: polyphenic determination
namespace: biological_process
def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues." [GOC:jid]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0048648
name: caste determination
namespace: biological_process
def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid]
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048649
name: caste determination, influence by genetic factors
namespace: biological_process
def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid]
is_a: GO:0048648 ! caste determination
is_a: GO:0048652 ! polyphenic determination, influence by genetic factors

[Term]
id: GO:0048650
name: caste determination, influence by environmental factors
namespace: biological_process
def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid]
is_a: GO:0048648 ! caste determination
is_a: GO:0048651 ! polyphenic determination, influence by environmental factors

[Term]
id: GO:0048651
name: polyphenic determination, influence by environmental factors
namespace: biological_process
def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues." [GOC:jid]
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048652
name: polyphenic determination, influence by genetic factors
namespace: biological_process
def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues." [GOC:jid]
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048653
name: anther development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure." [GOC:jid, GOC:sm]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0048654
name: anther morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anther are generated and organized." [GOC:jid, GOC:sm]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048448 ! stamen morphogenesis
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0048655
name: anther wall tapetum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anther wall tapetum are generated and organized. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb]
synonym: "differentiation of tapetal layer" NARROW []
synonym: "tapetal layer morphogenesis" BROAD [GOC:tb]
synonym: "tapetum morphogenesis" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0048654 ! anther morphogenesis
relationship: part_of GO:0048658 ! anther wall tapetum development

[Term]
id: GO:0048656
name: anther wall tapetum formation
namespace: biological_process
def: "The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb]
synonym: "tapetal layer formation" BROAD [GOC:tb]
synonym: "tapetum formation" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048455 ! stamen formation
relationship: part_of GO:0048655 ! anther wall tapetum morphogenesis

[Term]
id: GO:0048657
name: anther wall tapetum cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm]
synonym: "tapetal cell differentiation" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048656 ! anther wall tapetum formation

[Term]
id: GO:0048658
name: anther wall tapetum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure." [GOC:jid, GOC:sm, GOC:tb]
synonym: "tapetal layer development" BROAD [GOC:tb]
synonym: "tapetum development" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0048659
name: smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698]
synonym: "SMC proliferation" EXACT []
is_a: GO:0033002 ! muscle cell proliferation

[Term]
id: GO:0048660
name: regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "regulation of SMC proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048661
name: positive regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "activation of smooth muscle cell proliferation" NARROW []
synonym: "positive regulation of SMC proliferation" EXACT []
synonym: "stimulation of smooth muscle cell proliferation" NARROW []
synonym: "up regulation of smooth muscle cell proliferation" EXACT []
synonym: "up-regulation of smooth muscle cell proliferation" EXACT []
synonym: "upregulation of smooth muscle cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048662
name: negative regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "down regulation of smooth muscle cell proliferation" EXACT []
synonym: "down-regulation of smooth muscle cell proliferation" EXACT []
synonym: "downregulation of smooth muscle cell proliferation" EXACT []
synonym: "inhibition of smooth muscle cell proliferation" NARROW []
synonym: "negative regulation of SMC proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048663
name: neuron fate commitment
namespace: biological_process
alt_id: GO:0042055
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]
synonym: "neuron lineage restriction" EXACT []
synonym: "neuronal lineage restriction" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030182 ! neuron differentiation

[Term]
id: GO:0048664
name: neuron fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048663 ! neuron fate commitment

[Term]
id: GO:0048665
name: neuron fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048663 ! neuron fate commitment

[Term]
id: GO:0048666
name: neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030182 ! neuron differentiation

[Term]
id: GO:0048667
name: cell morphogenesis involved in neuron differentiation
namespace: biological_process
def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]
synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0048668
name: collateral sprouting
namespace: biological_process
def: "The process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "axon branching" BROAD [GOC:BHF, PMID:21463686]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0048669
name: collateral sprouting in absence of injury
namespace: biological_process
def: "The process in which outgrowths develop from the axons of intact undamaged neurons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048668 ! collateral sprouting

[Term]
id: GO:0048670
name: regulation of collateral sprouting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0050770 ! regulation of axonogenesis
is_a: GO:0061387 ! regulation of extent of cell growth
relationship: regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048671
name: negative regulation of collateral sprouting
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting" EXACT []
synonym: "down-regulation of collateral sprouting" EXACT []
synonym: "downregulation of collateral sprouting" EXACT []
synonym: "inhibition of collateral sprouting" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0050771 ! negative regulation of axonogenesis
relationship: negatively_regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048672
name: positive regulation of collateral sprouting
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting" NARROW []
synonym: "stimulation of collateral sprouting" NARROW []
synonym: "up regulation of collateral sprouting" EXACT []
synonym: "up-regulation of collateral sprouting" EXACT []
synonym: "upregulation of collateral sprouting" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0050772 ! positive regulation of axonogenesis
relationship: positively_regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048673
name: collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input." [GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0031103 ! axon regeneration
is_a: GO:0048668 ! collateral sprouting

[Term]
id: GO:0048674
name: collateral sprouting of injured axon
namespace: biological_process
def: "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048668 ! collateral sprouting
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048675
name: axon extension
namespace: biological_process
alt_id: GO:0048676
def: "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
synonym: "axon extension involved in development" EXACT []
is_a: GO:1990138 ! neuron projection extension
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0048677
name: axon extension involved in regeneration
namespace: biological_process
def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jid]
is_a: GO:0048675 ! axon extension
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048678
name: response to axon injury
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0048679
name: regulation of axon regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0070570 ! regulation of neuron projection regeneration
is_a: GO:1903034 ! regulation of response to wounding
relationship: regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048680
name: positive regulation of axon regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of axon regeneration" NARROW []
synonym: "stimulation of axon regeneration" NARROW []
synonym: "up regulation of axon regeneration" EXACT []
synonym: "up-regulation of axon regeneration" EXACT []
synonym: "upregulation of axon regeneration" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0048679 ! regulation of axon regeneration
is_a: GO:0070572 ! positive regulation of neuron projection regeneration
is_a: GO:1903036 ! positive regulation of response to wounding
relationship: positively_regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048681
name: negative regulation of axon regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of axon regeneration" EXACT []
synonym: "down-regulation of axon regeneration" EXACT []
synonym: "downregulation of axon regeneration" EXACT []
synonym: "inhibition of axon regeneration" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0048679 ! regulation of axon regeneration
is_a: GO:0070571 ! negative regulation of neuron projection regeneration
is_a: GO:1903035 ! negative regulation of response to wounding
relationship: negatively_regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048682
name: sprouting of injured axon
namespace: biological_process
def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0031103 ! axon regeneration

[Term]
id: GO:0048683
name: regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0048679 ! regulation of axon regeneration
relationship: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048684
name: positive regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting of intact axon in response to injury" NARROW []
synonym: "stimulation of collateral sprouting of intact axon in response to injury" NARROW []
synonym: "up regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "up-regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "upregulation of collateral sprouting of intact axon in response to injury" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury
relationship: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048685
name: negative regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "down-regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "downregulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "inhibition of collateral sprouting of intact axon in response to injury" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury
relationship: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048686
name: regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061387 ! regulation of extent of cell growth
relationship: regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048687
name: positive regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of sprouting of injured axon" NARROW []
synonym: "stimulation of sprouting of injured axon" NARROW []
synonym: "up regulation of sprouting of injured axon" EXACT []
synonym: "up-regulation of sprouting of injured axon" EXACT []
synonym: "upregulation of sprouting of injured axon" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: positively_regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048688
name: negative regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of sprouting of injured axon" EXACT []
synonym: "down-regulation of sprouting of injured axon" EXACT []
synonym: "downregulation of sprouting of injured axon" EXACT []
synonym: "inhibition of sprouting of injured axon" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: negatively_regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048689
name: formation of growth cone in injured axon
namespace: biological_process
def: "The formation of a growth cone in an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048690
name: regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048691
name: positive regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of axon extension involved in regeneration" NARROW []
synonym: "stimulation of axon extension involved in regeneration" NARROW []
synonym: "up regulation of axon extension involved in regeneration" EXACT []
synonym: "up-regulation of axon extension involved in regeneration" EXACT []
synonym: "upregulation of axon extension involved in regeneration" EXACT []
is_a: GO:0045773 ! positive regulation of axon extension
is_a: GO:0048687 ! positive regulation of sprouting of injured axon
is_a: GO:0048690 ! regulation of axon extension involved in regeneration
relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048692
name: negative regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of axon extension involved in regeneration" EXACT []
synonym: "down-regulation of axon extension involved in regeneration" EXACT []
synonym: "downregulation of axon extension involved in regeneration" EXACT []
synonym: "inhibition of axon extension involved in regeneration" NARROW []
is_a: GO:0030517 ! negative regulation of axon extension
is_a: GO:0048688 ! negative regulation of sprouting of injured axon
is_a: GO:0048690 ! regulation of axon extension involved in regeneration
relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048693
name: regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048694
name: positive regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting of injured axon" NARROW []
synonym: "stimulation of collateral sprouting of injured axon" NARROW []
synonym: "up regulation of collateral sprouting of injured axon" EXACT []
synonym: "up-regulation of collateral sprouting of injured axon" EXACT []
synonym: "upregulation of collateral sprouting of injured axon" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048687 ! positive regulation of sprouting of injured axon
is_a: GO:0048693 ! regulation of collateral sprouting of injured axon
relationship: positively_regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048695
name: negative regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting of injured axon" EXACT []
synonym: "down-regulation of collateral sprouting of injured axon" EXACT []
synonym: "downregulation of collateral sprouting of injured axon" EXACT []
synonym: "inhibition of collateral sprouting of injured axon" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048688 ! negative regulation of sprouting of injured axon
is_a: GO:0048693 ! regulation of collateral sprouting of injured axon
relationship: negatively_regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048696
name: regulation of collateral sprouting in absence of injury
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
relationship: regulates GO:0048669 ! collateral sprouting in absence of injury

[Term]
id: GO:0048697
name: positive regulation of collateral sprouting in absence of injury
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting in the absence of injury" NARROW []
synonym: "stimulation of collateral sprouting in the absence of injury" NARROW []
synonym: "up regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "up-regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "upregulation of collateral sprouting in the absence of injury" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury
relationship: positively_regulates GO:0048669 ! collateral sprouting in absence of injury

[Term]
id: GO:0048698
name: negative regulation of collateral sprouting in absence of injury
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "down-regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "downregulation of collateral sprouting in the absence of injury" EXACT []
synonym: "inhibition of collateral sprouting in the absence of injury" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury
relationship: negatively_regulates GO:0048669 ! collateral sprouting in absence of injury

[Term]
id: GO:0048699
name: generation of neurons
namespace: biological_process
def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]
synonym: "neuron generation" EXACT []
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0048700
name: acquisition of desiccation tolerance in seed
namespace: biological_process
def: "The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state." [GOC:jid, GOC:ki, GOC:PO_curators, ISBN:9781405139830]
synonym: "acquisition of desiccation tolerance" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0097439 ! acquisition of desiccation tolerance
relationship: part_of GO:0010162 ! seed dormancy process

[Term]
id: GO:0048701
name: embryonic cranial skeleton morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase." [GOC:dsf, GOC:jid, PMID:16049113]
synonym: "embryonic cranium morphogenesis" EXACT []
is_a: GO:0048704 ! embryonic skeletal system morphogenesis
relationship: part_of GO:1904888 ! cranial skeletal system development

[Term]
id: GO:0048702
name: embryonic neurocranium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain." [GOC:dsf, GOC:jid, PMID:16049113]
synonym: "embryonic braincase morphogenesis" EXACT []
synonym: "embryonic chondrocranium morphogenesis" EXACT [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis

[Term]
id: GO:0048703
name: embryonic viscerocranium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones." [GOC:dsf, GOC:jid, PMID:16049113]
synonym: "embryonic pharyngeal skeleton morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis

[Term]
id: GO:0048704
name: embryonic skeletal system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]
synonym: "embryonic skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0048706 ! embryonic skeletal system development

[Term]
id: GO:0048705
name: skeletal system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]
synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0001501 ! skeletal system development

[Term]
id: GO:0048706
name: embryonic skeletal system development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]
synonym: "embryonic skeletal development" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001501 ! skeletal system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0048707
name: instar larval or pupal morphogenesis
namespace: biological_process
def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized." [GOC:mtg_sensu, GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0048708
name: astrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0048709
name: oligodendrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0048710
name: regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048711
name: positive regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of astrocyte differentiation" NARROW []
synonym: "stimulation of astrocyte differentiation" NARROW []
synonym: "up regulation of astrocyte differentiation" EXACT []
synonym: "up-regulation of astrocyte differentiation" EXACT []
synonym: "upregulation of astrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
relationship: positively_regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048712
name: negative regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of astrocyte differentiation" EXACT []
synonym: "down-regulation of astrocyte differentiation" EXACT []
synonym: "downregulation of astrocyte differentiation" EXACT []
synonym: "inhibition of astrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
relationship: negatively_regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048713
name: regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048714
name: positive regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of oligodendrocyte differentiation" NARROW []
synonym: "stimulation of oligodendrocyte differentiation" NARROW []
synonym: "up regulation of oligodendrocyte differentiation" EXACT []
synonym: "up-regulation of oligodendrocyte differentiation" EXACT []
synonym: "upregulation of oligodendrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
relationship: positively_regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048715
name: negative regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of oligodendrocyte differentiation" EXACT []
synonym: "down-regulation of oligodendrocyte differentiation" EXACT []
synonym: "downregulation of oligodendrocyte differentiation" EXACT []
synonym: "inhibition of oligodendrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
relationship: negatively_regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048716
name: labrum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of labrum are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048726 ! labrum development

[Term]
id: GO:0048717
name: anterior cibarial plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior cibarial plate are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048722 ! anterior cibarial plate development

[Term]
id: GO:0048718
name: cibarial fish-trap bristle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc]
synonym: "fish trap bristle morphogenesis" RELATED [GOC:rc]
is_a: GO:0008407 ! chaeta morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048725 ! cibarial fish-trap bristle development

[Term]
id: GO:0048719
name: epistomal sclerite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the epistomal sclerite are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048724 ! epistomal sclerite development

[Term]
id: GO:0048720
name: posterior cibarial plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the posterior cibarial plate are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048727 ! posterior cibarial plate development

[Term]
id: GO:0048721
name: clypeus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the clypeus are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048723 ! clypeus development

[Term]
id: GO:0048722
name: anterior cibarial plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048723
name: clypeus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048724
name: epistomal sclerite development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048725
name: cibarial fish-trap bristle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc]
synonym: "fish-trap bristle development" EXACT [GOC:rc]
is_a: GO:0022416 ! chaeta development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048726
name: labrum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048727
name: posterior cibarial plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048728
name: proboscis development
namespace: biological_process
alt_id: GO:0016349
def: "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048729
name: tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009888 ! tissue development

[Term]
id: GO:0048730
name: epidermis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003]
synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0008544 ! epidermis development

[Term]
id: GO:0048731
name: system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]
subset: goslim_mouse
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0048732
name: gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0048733
name: sebaceous gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0048734
name: proboscis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0048728 ! proboscis development

[Term]
id: GO:0048735
name: haltere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a haltere are generated and organized." [GOC:jid, GOC:rc]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
relationship: part_of GO:0007481 ! haltere disc morphogenesis
relationship: part_of GO:0007482 ! haltere development

[Term]
id: GO:0048736
name: appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0048737
name: imaginal disc-derived appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jid, GOC:mtg_sensu, GOC:rc]
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0048738
name: cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
synonym: "heart muscle development" EXACT []
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0048740
name: obsolete striated muscle fiber development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
comment: This term was made obsolete because it was an unnecessary grouping term. Striated muscle comprises skeletal and cardiac muscle, but GO has opted not to group the muscle fiber development terms.
synonym: "myogenesis" EXACT []
synonym: "striated muscle fiber development" EXACT []
synonym: "striated muscle fibre development" EXACT []
is_obsolete: true

[Term]
id: GO:0048741
name: skeletal muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "skeletal muscle fibre development" EXACT []
synonym: "skeletal myofiber development" EXACT []
synonym: "skeletal myofibre development" EXACT []
is_a: GO:0014904 ! myotube cell development
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048742
name: regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]
synonym: "regulation of skeletal muscle fibre development" EXACT []
synonym: "regulation of skeletal myofiber development" EXACT []
synonym: "regulation of skeletal myofibre development" EXACT []
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048743
name: positive regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "activation of skeletal muscle fiber development" NARROW []
synonym: "positive regulation of skeletal muscle fibre development" EXACT []
synonym: "positive regulation of skeletal myofiber development" EXACT []
synonym: "positive regulation of skeletal myofibre development" EXACT []
synonym: "stimulation of skeletal muscle fiber development" NARROW []
synonym: "up regulation of skeletal muscle fiber development" EXACT []
synonym: "up-regulation of skeletal muscle fiber development" EXACT []
synonym: "upregulation of skeletal muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048744
name: negative regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "down regulation of skeletal muscle fiber development" EXACT []
synonym: "down-regulation of skeletal muscle fiber development" EXACT []
synonym: "downregulation of skeletal muscle fiber development" EXACT []
synonym: "inhibition of skeletal muscle fiber development" NARROW []
synonym: "negative regulation of skeletal muscle fibre development" EXACT []
synonym: "negative regulation of skeletal myofiber development" EXACT []
synonym: "negative regulation of skeletal myofibre development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048745
name: smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0060537 ! muscle tissue development

[Term]
id: GO:0048746
name: obsolete smooth muscle fiber development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
comment: This term was made obsolete because smooth muscle does not have fibers.
synonym: "smooth muscle fiber development" EXACT []
synonym: "smooth muscle fibre development" EXACT []
is_obsolete: true

[Term]
id: GO:0048749
name: compound eye development
namespace: biological_process
alt_id: GO:0007456
def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
synonym: "insect-type retina development" EXACT [PMID:11735386]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0048750
name: compound eye corneal lens morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0001745 ! compound eye morphogenesis
relationship: part_of GO:0048058 ! compound eye corneal lens development

[Term]
id: GO:0048752
name: semicircular canal morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the semicircular canals are generated and organized." [GOC:dgh, GOC:dph, GOC:jid]
synonym: "embryonic semicircular canal morphogenesis" EXACT []
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060872 ! semicircular canal development

[Term]
id: GO:0048753
name: pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]
subset: goslim_pir
synonym: "pigment granule organisation" EXACT []
synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0033059 ! cellular pigmentation

[Term]
id: GO:0048754
name: branching morphogenesis of an epithelial tube
namespace: biological_process
def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]
synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
relationship: part_of GO:0060562 ! epithelial tube morphogenesis

[Term]
id: GO:0048755
name: branching morphogenesis of a nerve
namespace: biological_process
def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001763 ! morphogenesis of a branching structure
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0048756
name: sieve cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [GOC:jid, PO:0025415, POC:curators]
is_a: GO:0090603 ! sieve element differentiation
relationship: part_of GO:0010088 ! phloem development

[Term]
id: GO:0048757
name: pigment granule maturation
namespace: biological_process
def: "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jid, GOC:mh]
is_a: GO:0021700 ! developmental maturation
is_a: GO:0043482 ! cellular pigment accumulation
relationship: part_of GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048758
name: companion cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jid]
is_a: GO:0048760 ! plant parenchymal cell differentiation
relationship: part_of GO:0010088 ! phloem development

[Term]
id: GO:0048759
name: xylem vessel member cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jid, PO:0002003]
synonym: "vessel element cell differentiation" BROAD []
synonym: "vessel member cell differentiation" BROAD []
is_a: GO:1905177 ! tracheary element differentiation
relationship: part_of GO:0010089 ! xylem development

[Term]
id: GO:0048760
name: plant parenchymal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure." [CL:0000668, GOC:jid, ISBN:069716957X, PO:0005421]
synonym: "parenchymal cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048761
name: collenchyma cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jid, PO:0000075]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048762
name: mesenchymal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060485 ! mesenchyme development

[Term]
id: GO:0048763
name: calcium-induced calcium release activity
namespace: molecular_function
def: "Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration." [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]
xref: Reactome:R-HSA-2855020 "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol"
is_a: GO:0015278 ! intracellularly gated calcium channel activity

[Term]
id: GO:0048764
name: trichoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jid]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0010054 ! trichoblast differentiation

[Term]
id: GO:0048765
name: root hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jid]
is_a: GO:0010053 ! root epidermal cell differentiation
is_a: GO:0048764 ! trichoblast maturation

[Term]
id: GO:0048766
name: root hair initiation
namespace: biological_process
def: "The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jid, PMID:12468740]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0048765 ! root hair cell differentiation

[Term]
id: GO:0048767
name: root hair elongation
namespace: biological_process
def: "The process in which the root hair grows longer." [GOC:jid, PMID:12468740]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0080147 ! root hair cell development

[Term]
id: GO:0048768
name: root hair cell tip growth
namespace: biological_process
def: "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jid, GOC:ki, PMID:12468740]
synonym: "root hair tip growth" EXACT []
is_a: GO:0009932 ! cell tip growth
relationship: part_of GO:0048767 ! root hair elongation

[Term]
id: GO:0048769
name: sarcomerogenesis
namespace: biological_process
def: "The process in which sarcomeres are added in series within a fiber." [GOC:jid, GOC:lm, PMID:15947030]
synonym: "myofibril production" EXACT systematic_synonym []
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0048770
name: pigment granule
namespace: cellular_component
def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0048771
name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
synonym: "tissue remodelling" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0048772
name: leucophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jid, GOC:mh]
synonym: "leucophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048773
name: erythrophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jid, GOC:mh]
synonym: "erythrophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048774
name: cyanophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jid, GOC:mh]
synonym: "cyanophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048775
name: regulation of leucophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048776
name: negative regulation of leucophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh]
synonym: "down regulation of leucophore differentiation" EXACT []
synonym: "down-regulation of leucophore differentiation" EXACT []
synonym: "downregulation of leucophore differentiation" EXACT []
synonym: "inhibition of leucophore differentiation" NARROW []
is_a: GO:0048775 ! regulation of leucophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048777
name: positive regulation of leucophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh]
synonym: "activation of leucophore differentiation" NARROW []
synonym: "stimulation of leucophore differentiation" NARROW []
synonym: "up regulation of leucophore differentiation" EXACT []
synonym: "up-regulation of leucophore differentiation" EXACT []
synonym: "upregulation of leucophore differentiation" EXACT []
is_a: GO:0048775 ! regulation of leucophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048778
name: regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048779
name: negative regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
synonym: "down regulation of erythrophore differentiation" EXACT []
synonym: "down-regulation of erythrophore differentiation" EXACT []
synonym: "downregulation of erythrophore differentiation" EXACT []
synonym: "inhibition of erythrophore differentiation" NARROW []
is_a: GO:0048778 ! regulation of erythrophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048780
name: positive regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
synonym: "activation of erythrophore differentiation" NARROW []
synonym: "stimulation of erythrophore differentiation" NARROW []
synonym: "up regulation of erythrophore differentiation" EXACT []
synonym: "up-regulation of erythrophore differentiation" EXACT []
synonym: "upregulation of erythrophore differentiation" EXACT []
is_a: GO:0048778 ! regulation of erythrophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048781
name: regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048782
name: negative regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
synonym: "down regulation of cyanophore differentiation" EXACT []
synonym: "down-regulation of cyanophore differentiation" EXACT []
synonym: "downregulation of cyanophore differentiation" EXACT []
synonym: "inhibition of cyanophore differentiation" NARROW []
is_a: GO:0048781 ! regulation of cyanophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048783
name: positive regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
synonym: "activation of cyanophore differentiation" NARROW []
synonym: "stimulation of cyanophore differentiation" NARROW []
synonym: "up regulation of cyanophore differentiation" EXACT []
synonym: "up-regulation of cyanophore differentiation" EXACT []
synonym: "upregulation of cyanophore differentiation" EXACT []
is_a: GO:0048781 ! regulation of cyanophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048784
name: pigment biosynthetic process involved in pigment granule maturation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jid]
synonym: "pigment biosynthetic process during pigment granule maturation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation
is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation
relationship: part_of GO:0048757 ! pigment granule maturation

[Term]
id: GO:0048785
name: hatching gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jid]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048786
name: presynaptic active zone
namespace: cellular_component
def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
subset: goslim_synapse
synonym: "pre-synaptic active zone" EXACT []
synonym: "pre-synaptic active zone component" NARROW [NIF_Subcellular:sao1911631652]
synonym: "presynaptic specialization" EXACT []
xref: NIF_Subcellular:sao792027222
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0048787
name: presynaptic active zone membrane
namespace: cellular_component
def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289]
subset: goslim_synapse
synonym: "active zone plasma membrane" EXACT [NIF_Subcellular:sao2038461087]
synonym: "active zone pre-synaptic plasma membrane" EXACT []
synonym: "active zone presynaptic plasma membrane" EXACT []
synonym: "pre-synaptic active zone membrane" EXACT []
xref: NIF_Subcellular:sao2038461087
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0048788
name: cytoskeleton of presynaptic active zone
namespace: cellular_component
def: "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438]
synonym: "active zone cytomatrix" EXACT []
synonym: "CAZ" NARROW []
synonym: "pre-synaptic cytoskeletal matrix assembled at active zones" EXACT []
synonym: "pre-synaptic dense body" NARROW [NIF_Subcellular:sao1111202255, PMID:12575947]
synonym: "pre-synaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao1488888179]
synonym: "presynaptic cytomatrix assembled at active zones" EXACT []
synonym: "presynaptic cytoskeletal matrix" EXACT syngo_official_label []
synonym: "presynaptic cytoskeletal matrix assembled at active zones" EXACT []
synonym: "presynaptic dense body" NARROW [PMID:16709774]
synonym: "presynaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao1488888179]
synonym: "ribbon" RELATED [NIF_Subcellular:sao1111202255, PMID:12575947]
synonym: "synaptic ribbon" NARROW [PMID:19264728]
synonym: "T-bar" NARROW [PMID:20127822]
synonym: "T-bar ribbon" NARROW [PMID:16384719]
xref: NIF_Subcellular:sao1470121605
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0099569 ! presynaptic cytoskeleton
relationship: part_of GO:0098831 ! presynaptic active zone cytoplasmic component

[Term]
id: GO:0048789
name: cytoskeletal matrix organization at active zone
namespace: biological_process
def: "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759]
synonym: "cytoskeletal matrix organisation at active zone" EXACT [GOC:mah]
is_a: GO:0030865 ! cortical cytoskeleton organization

[Term]
id: GO:0048790
name: maintenance of presynaptic active zone structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
subset: goslim_synapse
synonym: "maintenance of pre-synaptic active zone structure" EXACT []
is_a: GO:0099558 ! maintenance of synapse structure
is_a: GO:1990709 ! presynaptic active zone organization

[Term]
id: GO:0048791
name: calcium ion-regulated exocytosis of neurotransmitter
namespace: biological_process
def: "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators]
is_a: GO:0016079 ! synaptic vesicle exocytosis
is_a: GO:0017156 ! calcium-ion regulated exocytosis

[Term]
id: GO:0048792
name: spontaneous exocytosis of neurotransmitter
namespace: biological_process
def: "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators]
synonym: "spontaneous synaptic vesicle exocytosis" EXACT []
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0048793
name: pronephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151]
synonym: "pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0048794
name: swim bladder development
namespace: biological_process
def: "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder development" EXACT []
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0048795
name: swim bladder morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder morphogenesis" EXACT []
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0048794 ! swim bladder development

[Term]
id: GO:0048796
name: swim bladder maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol]
synonym: "gas bladder maturation" EXACT []
is_a: GO:0048799 ! animal organ maturation
relationship: part_of GO:0048794 ! swim bladder development

[Term]
id: GO:0048797
name: swim bladder formation
namespace: biological_process
def: "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder biosynthesis" EXACT []
synonym: "gas bladder formation" EXACT []
is_a: GO:0048645 ! animal organ formation
relationship: part_of GO:0048795 ! swim bladder morphogenesis

[Term]
id: GO:0048798
name: swim bladder inflation
namespace: biological_process
def: "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder inflation" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048796 ! swim bladder maturation

[Term]
id: GO:0048799
name: animal organ maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0048800
name: antennal morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0007469 ! antennal development

[Term]
id: GO:0048801
name: antennal joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the antennal joint are generated and organized." [GOC:jid]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0048098 ! antennal joint development
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0048802
name: notum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007472 ! wing disc morphogenesis
relationship: part_of GO:0007477 ! notum development

[Term]
id: GO:0048803
name: imaginal disc-derived male genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
synonym: "male genital morphogenesis" BROAD []
is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis
is_a: GO:0048808 ! male genitalia morphogenesis
relationship: part_of GO:0007485 ! imaginal disc-derived male genitalia development

[Term]
id: GO:0048804
name: imaginal disc-derived female genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of female genitalia are generated and organized from the genital disc." [GOC:ai, GOC:sensu]
synonym: "female genital morphogenesis" BROAD []
is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis
is_a: GO:0048807 ! female genitalia morphogenesis
relationship: part_of GO:0007486 ! imaginal disc-derived female genitalia development

[Term]
id: GO:0048805
name: imaginal disc-derived genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
synonym: "genital morphogenesis" BROAD []
is_a: GO:0035126 ! post-embryonic genitalia morphogenesis
relationship: part_of GO:0007483 ! genital disc morphogenesis
relationship: part_of GO:0007484 ! imaginal disc-derived genitalia development

[Term]
id: GO:0048806
name: genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
synonym: "genital development" EXACT []
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0048807
name: female genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of female genitalia are generated and organized." [GOC:mah]
synonym: "female genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
relationship: part_of GO:0030540 ! female genitalia development

[Term]
id: GO:0048808
name: male genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888]
synonym: "male genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0090598 ! male anatomical structure morphogenesis
relationship: part_of GO:0030539 ! male genitalia development

[Term]
id: GO:0048809
name: analia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007483 ! genital disc morphogenesis
relationship: part_of GO:0007487 ! analia development

[Term]
id: GO:0048810
name: female analia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0048809 ! analia morphogenesis
relationship: part_of GO:0045497 ! female analia development

[Term]
id: GO:0048811
name: male analia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0048809 ! analia morphogenesis
relationship: part_of GO:0045496 ! male analia development

[Term]
id: GO:0048812
name: neuron projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis
relationship: part_of GO:0031175 ! neuron projection development

[Term]
id: GO:0048813
name: dendrite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a dendrite are generated and organized." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0016358 ! dendrite development
relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation

[Term]
id: GO:0048814
name: regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0050773 ! regulation of dendrite development
relationship: regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0048815
name: obsolete hermaphrodite genitalia morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of hermaphrodite genitalia are generated and organized." [GOC:ems, ISBN:0140512888]
comment: The reason for obsoletion is that this term maybe redundant with female genitalia morphogenesis.
is_obsolete: true
consider: GO:0048807

[Term]
id: GO:0048816
name: ocellus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0008056 ! ocellus development

[Term]
id: GO:0048817
name: negative regulation of hair follicle maturation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
synonym: "down regulation of hair follicle maturation" EXACT []
synonym: "down-regulation of hair follicle maturation" EXACT []
synonym: "downregulation of hair follicle maturation" EXACT []
synonym: "inhibition of hair follicle maturation" NARROW []
is_a: GO:0048819 ! regulation of hair follicle maturation
is_a: GO:0051799 ! negative regulation of hair follicle development
relationship: negatively_regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048818
name: positive regulation of hair follicle maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
synonym: "activation of hair follicle maturation" NARROW []
synonym: "stimulation of hair follicle maturation" NARROW []
synonym: "up regulation of hair follicle maturation" EXACT []
synonym: "up-regulation of hair follicle maturation" EXACT []
synonym: "upregulation of hair follicle maturation" EXACT []
is_a: GO:0048819 ! regulation of hair follicle maturation
is_a: GO:0051798 ! positive regulation of hair follicle development
relationship: positively_regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048819
name: regulation of hair follicle maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048820
name: hair follicle maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol]
is_a: GO:0022405 ! hair cycle process
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0001942 ! hair follicle development

[Term]
id: GO:0048821
name: erythrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol]
synonym: "RBC development" EXACT [CL:0000232]
synonym: "red blood cell development" EXACT [CL:0000232]
is_a: GO:0061515 ! myeloid cell development
relationship: part_of GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0048822
name: enucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "enucleate RBC development" EXACT [CL:0000232]
synonym: "enucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation

[Term]
id: GO:0048823
name: nucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "nucleate RBC development" EXACT [CL:0000232]
synonym: "nucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation

[Term]
id: GO:0048824
name: pigment cell precursor differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899]
synonym: "chromatophore precursor differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048825
name: cotyledon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030]
is_a: GO:0009793 ! embryo development ending in seed dormancy
is_a: GO:0048366 ! leaf development

[Term]
id: GO:0048826
name: cotyledon morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030]
is_a: GO:0009965 ! leaf morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0090698 ! post-embryonic plant morphogenesis
relationship: part_of GO:0048825 ! cotyledon development

[Term]
id: GO:0048827
name: phyllome development
namespace: biological_process
def: "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001]
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0048829
name: root cap development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0048830
name: adventitious root development
namespace: biological_process
def: "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb]
is_a: GO:0048364 ! root development

[Term]
id: GO:0048831
name: regulation of shoot system development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392]
synonym: "regulation of shoot development" EXACT []
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048367 ! shoot system development

[Term]
id: GO:0048832
name: specification of plant organ number
namespace: biological_process
def: "The regionalization process that modulates the quantity of a particular type of plant organ." [GOC:dph, GOC:isa_complete, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0048833
name: specification of floral organ number
namespace: biological_process
def: "Any process that modulates the number of floral organs formed in a floral whorl." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048832 ! specification of plant organ number
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048834
name: specification of petal number
namespace: biological_process
def: "Any process that modulates the number of petals formed in a flower." [GOC:tb]
is_a: GO:0048833 ! specification of floral organ number
relationship: part_of GO:0048465 ! corolla development

[Term]
id: GO:0048835
name: specification of decreased petal number
namespace: biological_process
def: "Any process that reduces the number of petals produced in a developing flower." [GOC:tb]
is_a: GO:0048834 ! specification of petal number

[Term]
id: GO:0048836
name: specification of increased petal number
namespace: biological_process
def: "Any process that increases the number of petals produced in a developing flower." [GOC:tb]
is_a: GO:0048834 ! specification of petal number

[Term]
id: GO:0048837
name: sorocarp sorus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorocarp sorus over time, from its formation to the mature structure. A sorocarp sorus is the spore containing structure of a sorocarp." [GOC:devbiol, GOC:mtg_sensu, PMID:4332228]
synonym: "sorocarp sorus formation" EXACT []
synonym: "sorocarp spore head formation" EXACT []
synonym: "sorocarp spore head morphogenesis" RELATED []
is_a: GO:0099120 ! socially cooperative development
relationship: part_of GO:0031154 ! culmination involved in sorocarp development

[Term]
id: GO:0048838
name: release of seed from dormancy
namespace: biological_process
def: "The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jid, GOC:tb, ISBN:9781405139830]
is_a: GO:0010162 ! seed dormancy process
is_a: GO:0097438 ! exit from dormancy

[Term]
id: GO:0048839
name: inner ear development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043583 ! ear development

[Term]
id: GO:0048840
name: otolith development
namespace: biological_process
def: "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0048841
name: regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
is_a: GO:0030516 ! regulation of axon extension
relationship: regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048842
name: positive regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
synonym: "activation of axon extension involved in axon guidance" NARROW []
synonym: "stimulation of axon extension involved in axon guidance" NARROW []
synonym: "up regulation of axon extension involved in axon guidance" EXACT []
synonym: "up-regulation of axon extension involved in axon guidance" EXACT []
synonym: "upregulation of axon extension involved in axon guidance" EXACT []
is_a: GO:0045773 ! positive regulation of axon extension
is_a: GO:0048841 ! regulation of axon extension involved in axon guidance
is_a: GO:0050921 ! positive regulation of chemotaxis
relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048843
name: negative regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
synonym: "down regulation of axon extension involved in axon guidance" EXACT []
synonym: "down-regulation of axon extension involved in axon guidance" EXACT []
synonym: "downregulation of axon extension involved in axon guidance" EXACT []
synonym: "inhibition of axon extension involved in axon guidance" NARROW []
is_a: GO:0030517 ! negative regulation of axon extension
is_a: GO:0048841 ! regulation of axon extension involved in axon guidance
is_a: GO:0050922 ! negative regulation of chemotaxis
relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048844
name: artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480]
synonym: "arterial morphogenesis" EXACT []
synonym: "arteriogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060840 ! artery development

[Term]
id: GO:0048845
name: venous blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480]
synonym: "vein morphogenesis" BROAD []
synonym: "venous morphogenesis" EXACT []
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060841 ! venous blood vessel development

[Term]
id: GO:0048846
name: axon extension involved in axon guidance
namespace: biological_process
def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid]
is_a: GO:0048675 ! axon extension
is_a: GO:1902284 ! neuron projection extension involved in neuron projection guidance
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:0048847
name: adenohypophysis formation
namespace: biological_process
def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis biosynthesis" EXACT []
synonym: "adenophysis formation" EXACT []
synonym: "anterior pituitary biosynthesis" EXACT []
synonym: "anterior pituitary formation" EXACT []
synonym: "anterior pituitary gland biosynthesis" EXACT []
synonym: "anterior pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048855 ! adenohypophysis morphogenesis

[Term]
id: GO:0048848
name: neurohypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis morphogenesis" EXACT []
synonym: "posterior pituitary gland morphogenesis" EXACT []
synonym: "posterior pituitary morphogenesis" EXACT []
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0021985 ! neurohypophysis development
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048849
name: neurohypophysis formation
namespace: biological_process
def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis biosynthesis" EXACT []
synonym: "neurophysis formation" EXACT []
synonym: "posterior pituitary biosynthesis" EXACT []
synonym: "posterior pituitary formation" EXACT []
synonym: "posterior pituitary gland biosynthesis" EXACT []
synonym: "posterior pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048848 ! neurohypophysis morphogenesis

[Term]
id: GO:0048850
name: hypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "pituitary gland morphogenesis" EXACT []
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0021983 ! pituitary gland development
relationship: part_of GO:0048852 ! diencephalon morphogenesis

[Term]
id: GO:0048851
name: hypophysis formation
namespace: biological_process
def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "hypophysis biosynthesis" EXACT []
synonym: "pituitary gland biosynthesis" EXACT []
synonym: "pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048852
name: diencephalon morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0048853 ! forebrain morphogenesis

[Term]
id: GO:0048853
name: forebrain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "prosencephalon morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030900 ! forebrain development
relationship: part_of GO:0048854 ! brain morphogenesis

[Term]
id: GO:0048854
name: brain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0048855
name: adenohypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis morphogenesis" EXACT []
synonym: "anterior pituitary gland morphogenesis" EXACT []
synonym: "anterior pituitary morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021984 ! adenohypophysis development
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048856
name: anatomical structure development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "development of an anatomical structure" EXACT []
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048857
name: neural nucleus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0048858
name: cell projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0030030 ! cell projection organization
relationship: part_of GO:0000902 ! cell morphogenesis

[Term]
id: GO:0048859
name: formation of anatomical boundary
namespace: biological_process
def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0048860
name: glioblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0048861
name: leukemia inhibitory factor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a leukemia inhibitory factor to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:devbiol, GOC:signaling]
synonym: "leukemia inhibitory factor signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme-linked receptor protein signaling pathway

[Term]
id: GO:0048863
name: stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
xref: Wikipedia:Stem_cell_differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048864
name: stem cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048863 ! stem cell differentiation

[Term]
id: GO:0048865
name: stem cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0048863 ! stem cell differentiation

[Term]
id: GO:0048866
name: stem cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048865 ! stem cell fate commitment

[Term]
id: GO:0048867
name: stem cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048865 ! stem cell fate commitment

[Term]
id: GO:0048868
name: pollen tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0048869
name: cellular developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]
is_a: GO:0009987 ! cellular process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048870
name: cell motility
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_prokaryote
synonym: "cell locomotion" EXACT []
synonym: "cell movement" RELATED []
synonym: "movement of a cell" EXACT []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0048871
name: multicellular organismal-level homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048872
name: homeostasis of number of cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]
synonym: "cell population homeostasis" EXACT []
synonym: "homeostasis of cell number" EXACT [GOC:dph]
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0048873
name: homeostasis of number of cells within a tissue
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete]
is_a: GO:0001894 ! tissue homeostasis
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0048874
name: host-mediated regulation of intestinal microbiota composition
namespace: biological_process
def: "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut." [PMID:25757720]
synonym: "homeostasis of number of cells in a free-living population" RELATED []
synonym: "host-induced regulation of intestinal microbiota composition" RELATED []
is_a: GO:0048872 ! homeostasis of number of cells
is_a: GO:0051851 ! modulation by host of symbiont process

[Term]
id: GO:0048875
name: obsolete chemical homeostasis within a tissue
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue." [GOC:isa_complete]
comment: The definition of this term is vague.
is_obsolete: true

[Term]
id: GO:0048876
name: obsolete chemical homeostasis within retina
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina." [GOC:isa_complete]
comment: The definition of this term is vague.
is_obsolete: true

[Term]
id: GO:0048877
name: homeostasis of number of retina cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb]
is_a: GO:0001895 ! retina homeostasis
is_a: GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0048878
name: chemical homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete]
subset: goslim_drosophila
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048880
name: sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048731 ! system development

[Term]
id: GO:0048881
name: mechanosensory lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509]
synonym: "LL system development" EXACT [ISBN:0125296509]
is_a: GO:0048925 ! lateral line system development

[Term]
id: GO:0048882
name: lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509]
synonym: "LL development" EXACT []
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048883
name: neuromast primordium migration
namespace: biological_process
def: "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385]
synonym: "lateral line primordium migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048882 ! lateral line development

[Term]
id: GO:0048884
name: neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0048882 ! lateral line development

[Term]
id: GO:0048885
name: neuromast deposition
namespace: biological_process
def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940]
is_a: GO:0030336 ! negative regulation of cell migration
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048886
name: neuromast hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [CL:0000856, ISBN:0125296509]
is_a: GO:0035315 ! hair cell differentiation
is_a: GO:0042490 ! mechanoreceptor differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048887
name: cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048888
name: neuromast mantle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048889
name: neuromast support cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048890
name: lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377]
synonym: "gLL ganglion development" EXACT []
is_a: GO:0061550 ! cranial ganglion development
relationship: part_of GO:0007422 ! peripheral nervous system development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048891
name: lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940]
synonym: "gLL neuron differentiation" EXACT []
is_a: GO:0048934 ! peripheral nervous system neuron differentiation
relationship: part_of GO:0048890 ! lateral line ganglion development

[Term]
id: GO:0048892
name: lateral line nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509]
synonym: "nLL development" EXACT []
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048893
name: afferent axon development in lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385]
is_a: GO:0061564 ! axon development
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048894
name: efferent axon development in a lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385]
is_a: GO:0021955 ! central nervous system neuron axonogenesis
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048895
name: lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048896
name: lateral line nerve glial cell migration
namespace: biological_process
def: "The movement of a glial cell along the axons in a lateral line nerve." [PMID:12062041]
synonym: "glial cell migration in lateral line nerve" EXACT []
is_a: GO:0008347 ! glial cell migration
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048897
name: myelination of lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of a lateral line nerve." [PMID:12112375]
is_a: GO:0042552 ! myelination
relationship: part_of GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048898
name: anterior lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]
synonym: "ALL system development" RELATED []
is_a: GO:0048925 ! lateral line system development
relationship: part_of GO:0048881 ! mechanosensory lateral line system development

[Term]
id: GO:0048899
name: anterior lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]
synonym: "anterior LL development" EXACT []
is_a: GO:0048882 ! lateral line development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048900
name: anterior lateral line neuromast primordium migration
namespace: biological_process
def: "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]
synonym: "ALL neuromast primordium migration" EXACT []
is_a: GO:0048883 ! neuromast primordium migration
relationship: part_of GO:0048899 ! anterior lateral line development

[Term]
id: GO:0048901
name: anterior lateral line neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0048884 ! neuromast development
relationship: part_of GO:0048899 ! anterior lateral line development

[Term]
id: GO:0048902
name: anterior lateral line neuromast deposition
namespace: biological_process
def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385]
is_a: GO:0048885 ! neuromast deposition
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048903
name: anterior lateral line neuromast hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377]
is_a: GO:0048886 ! neuromast hair cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048904
name: anterior lateral line neuromast cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048887 ! cupula development
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048905
name: anterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0048888 ! neuromast mantle cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048906
name: anterior lateral line neuromast support cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]
is_a: GO:0048889 ! neuromast support cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048907
name: anterior lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]
synonym: "gALL development" EXACT []
is_a: GO:0048890 ! lateral line ganglion development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048908
name: anterior lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940]
is_a: GO:0048891 ! lateral line ganglion neuron differentiation
relationship: part_of GO:0048907 ! anterior lateral line ganglion development

[Term]
id: GO:0048909
name: anterior lateral line nerve development
namespace: biological_process
alt_id: GO:0021734
def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509]
synonym: "ALLN development" EXACT []
synonym: "nALL development" EXACT []
synonym: "rostral lateral line nerve development" EXACT []
is_a: GO:0048892 ! lateral line nerve development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048910
name: afferent axon development in anterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940]
is_a: GO:0048893 ! afferent axon development in lateral line nerve
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048911
name: efferent axon development in anterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940]
is_a: GO:0048894 ! efferent axon development in a lateral line nerve
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048912
name: glial cell migration in anterior lateral line nerve
namespace: biological_process
def: "The movement of a glial cell along the axons in the anterior lateral line nerve." [PMID:12062041]
is_a: GO:0048896 ! lateral line nerve glial cell migration
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048913
name: anterior lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385]
is_a: GO:0048895 ! lateral line nerve glial cell differentiation
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048914
name: myelination of anterior lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375]
is_a: GO:0048897 ! myelination of lateral line nerve axons
relationship: part_of GO:0048940 ! anterior lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048915
name: posterior lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]
synonym: "PLL" RELATED []
is_a: GO:0048925 ! lateral line system development
relationship: part_of GO:0048881 ! mechanosensory lateral line system development

[Term]
id: GO:0048916
name: posterior lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509]
synonym: "PLL development" EXACT []
is_a: GO:0048882 ! lateral line development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048917
name: posterior lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377]
synonym: "gPLL development" EXACT []
is_a: GO:0048890 ! lateral line ganglion development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048918
name: posterior lateral line nerve development
namespace: biological_process
alt_id: GO:0021733
def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509]
synonym: "caudal lateral line nerve development" EXACT []
synonym: "PLLN development" EXACT []
is_a: GO:0048892 ! lateral line nerve development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048919
name: posterior lateral line neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0048884 ! neuromast development
relationship: part_of GO:0048916 ! posterior lateral line development

[Term]
id: GO:0048920
name: posterior lateral line neuromast primordium migration
namespace: biological_process
def: "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]
synonym: "PLL neuromast primordium migration" EXACT []
is_a: GO:0048883 ! neuromast primordium migration
relationship: part_of GO:0048916 ! posterior lateral line development

[Term]
id: GO:0048921
name: posterior lateral line neuromast cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048887 ! cupula development
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048922
name: posterior lateral line neuromast deposition
namespace: biological_process
def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385]
is_a: GO:0048885 ! neuromast deposition
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048923
name: posterior lateral line neuromast hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509]
is_a: GO:0048886 ! neuromast hair cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048924
name: posterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0048888 ! neuromast mantle cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048925
name: lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509]
is_a: GO:0048880 ! sensory system development

[Term]
id: GO:0048926
name: electrosensory lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048925 ! lateral line system development

[Term]
id: GO:0048927
name: posterior lateral line neuromast support cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]
is_a: GO:0048889 ! neuromast support cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048928
name: posterior lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940]
is_a: GO:0048891 ! lateral line ganglion neuron differentiation
relationship: part_of GO:0048917 ! posterior lateral line ganglion development

[Term]
id: GO:0048929
name: efferent axon development in posterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940]
is_a: GO:0048894 ! efferent axon development in a lateral line nerve
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048930
name: glial cell migration in posterior lateral line nerve
namespace: biological_process
def: "The movement of a glial cell along the axons in the posterior lateral line nerve." [PMID:12062041]
is_a: GO:0048896 ! lateral line nerve glial cell migration
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048931
name: posterior lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385]
is_a: GO:0048895 ! lateral line nerve glial cell differentiation
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048932
name: myelination of posterior lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375]
is_a: GO:0048897 ! myelination of lateral line nerve axons
relationship: part_of GO:0048942 ! posterior lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048933
name: afferent axon development in posterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940]
is_a: GO:0048893 ! afferent axon development in lateral line nerve
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048934
name: peripheral nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0048935
name: peripheral nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation

[Term]
id: GO:0048936
name: peripheral nervous system neuron axonogenesis
namespace: biological_process
def: "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh]
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0048935 ! peripheral nervous system neuron development

[Term]
id: GO:0048937
name: lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048895 ! lateral line nerve glial cell differentiation

[Term]
id: GO:0048938
name: lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0048937 ! lateral line nerve glial cell development

[Term]
id: GO:0048939
name: anterior lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0048937 ! lateral line nerve glial cell development
relationship: part_of GO:0048913 ! anterior lateral line nerve glial cell differentiation

[Term]
id: GO:0048940
name: anterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh]
is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation
relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development

[Term]
id: GO:0048941
name: posterior lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0048937 ! lateral line nerve glial cell development
relationship: part_of GO:0048931 ! posterior lateral line nerve glial cell differentiation

[Term]
id: GO:0048942
name: posterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh]
is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation
relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development

[Term]
id: GO:0050000
name: chromosome localization
namespace: biological_process
def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "chromosome localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of chromosome localization" EXACT []
synonym: "establishment and maintenance of chromosome position" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0050001
name: D-glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN]
synonym: "D-glutamine amidohydrolase activity" RELATED [EC:3.5.1.35]
xref: EC:3.5.1.35
xref: MetaCyc:D-GLUTAMINASE-RXN
xref: RHEA:22840
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050002
name: D-proline reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline." [EC:1.21.4.1]
synonym: "5-aminopentanoate:[PrdC protein] oxidoreductase (cyclizing) activity" RELATED [EC:1.21.4.1]
synonym: "D-proline reductase (dithiol) activity" RELATED [EC:1.21.4.1]
xref: EC:1.21.4.1
xref: MetaCyc:1.21.4.1-RXN
xref: RHEA:12737
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0050003
name: deoxycytidylate C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, RHEA:11568]
synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" RELATED [EC:2.1.1.54]
synonym: "dCMP methyltransferase activity" RELATED [EC:2.1.1.54]
synonym: "deoxycytidylate methyltransferase activity" RELATED [EC:2.1.1.54]
xref: EC:2.1.1.54
xref: KEGG_REACTION:R01670
xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN
xref: RHEA:11568
is_a: GO:0008169 ! C-methyltransferase activity

[Term]
id: GO:0050004
name: isoflavone 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.170]
synonym: "UDPglucose-flavonoid 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.170]
synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.170]
synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.170]
synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.170]
xref: EC:2.4.1.170
xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:56344
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050005
name: isohexenylglutaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O." [EC:4.2.1.57, RHEA:24144]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" RELATED [EC:4.2.1.57]
synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" RELATED [EC:4.2.1.57]
synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" RELATED [EC:4.2.1.57]
synonym: "isohexenylglutaconyl coenzyme A hydratase activity" RELATED [EC:4.2.1.57]
xref: EC:4.2.1.57
xref: KEGG_REACTION:R03493
xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN
xref: RHEA:24144
xref: UM-BBD_reactionID:r1167
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050006
name: isomaltulose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN]
synonym: "isomaltulose synthetase activity" RELATED [EC:5.4.99.11]
synonym: "sucrose alpha-glucosyltransferase activity" RELATED [EC:5.4.99.11]
synonym: "sucrose glucosylmutase activity" RELATED [EC:5.4.99.11]
synonym: "trehalulose synthase activity" RELATED [EC:5.4.99.11]
xref: EC:5.4.99.11
xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN
xref: RHEA:24032
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050007
name: isonocardicin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H+ + isonocardicin A." [EC:2.5.1.38, RHEA:19845]
synonym: "nocardicin aminocarboxypropyltransferase activity" RELATED [EC:2.5.1.38]
synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" RELATED [EC:2.5.1.38]
xref: EC:2.5.1.38
xref: KEGG_REACTION:R03072
xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN
xref: RHEA:19845
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050008
name: isopiperitenone delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopiperitenone = piperitenone." [RHEA:21516]
synonym: "isopiperitenone D-isomerase activity" EXACT []
synonym: "isopiperitenone delta8-delta4-isomerase activity" RELATED [EC:5.3.3.11]
xref: EC:5.3.3.11
xref: KEGG_REACTION:R03782
xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN
xref: RHEA:21516
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050009
name: isopropanol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + propan-2-ol = acetone + H+ + NADPH." [EC:1.1.1.80, RHEA:21792]
synonym: "propan-2-ol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.80]
xref: EC:1.1.1.80
xref: KEGG_REACTION:R01550
xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21792
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050010
name: isovitexin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: isovitexin + UDP-D-glucose = H+ + isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, RHEA:19529]
synonym: "isovitexin b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.106]
synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.106]
synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" RELATED [EC:2.4.1.106]
xref: EC:2.4.1.106
xref: KEGG_REACTION:R03686
xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:19529
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050011
name: itaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN]
synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" RELATED [EC:4.2.1.56]
synonym: "citramalyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.56]
synonym: "itaconyl coenzyme A hydratase activity" RELATED [EC:4.2.1.56]
xref: EC:4.2.1.56
xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN
xref: RHEA:13785
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050012
name: juglone 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+." [PMID:4041238, RHEA:18745]
synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" RELATED []
synonym: "juglone 3-monooxygenase activity" EXACT []
synonym: "juglone hydroxylase activity" EXACT []
synonym: "naphthoquinone hydroxylase activity" RELATED [EC:1.17.3.4]
xref: EC:1.17.3.4
xref: KEGG_REACTION:R04327
xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN
xref: RHEA:18745
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0050013
name: 2-dehydropantoate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN]
synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" RELATED [EC:4.1.2.12]
synonym: "2-dehydropantoate formaldehyde-lyase activity" RELATED [EC:4.1.2.12]
synonym: "ketopantoaldolase activity" EXACT []
xref: EC:4.1.2.12
xref: MetaCyc:KETOPANTOALDOLASE-RXN
xref: RHEA:23276
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050014
name: ketotetrose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate." [EC:4.1.2.2, RHEA:20932]
synonym: "erythrose-1-phosphate synthase activity" RELATED [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" RELATED [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate synthetase activity" RELATED [EC:4.1.2.2]
synonym: "phosphoketotetrose aldolase activity" RELATED [EC:4.1.2.2]
xref: EC:4.1.2.2
xref: KEGG_REACTION:R01014
xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN
xref: RHEA:20932
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050015
name: kievitone hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: kievitone hydrate = H2O + H+ + kievitone." [EC:4.2.1.95, RHEA:23604]
synonym: "KHase activity" RELATED [EC:4.2.1.95]
synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" RELATED [EC:4.2.1.95]
synonym: "kievitone-hydrate hydro-lyase activity" RELATED [EC:4.2.1.95]
xref: EC:4.2.1.95
xref: KEGG_REACTION:R03622
xref: MetaCyc:KIEVITONE-HYDRATASE-RXN
xref: RHEA:23604
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050016
name: kynurenine 7,8-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN]
synonym: "kynurenate 7,8-hydroxylase activity" RELATED [EC:1.14.99.2]
synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.99.2]
synonym: "kynurenic acid hydroxylase activity" RELATED [EC:1.14.99.2]
synonym: "kynurenic hydroxylase activity" RELATED [EC:1.14.99.2]
xref: EC:1.14.99.2
xref: MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN
xref: RHEA:11968
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050017
name: L-3-cyanoalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN]
synonym: "beta-cyano-L-alanine synthase activity" RELATED [EC:4.4.1.9]
synonym: "beta-cyanoalanine synthase activity" RELATED [EC:4.4.1.9]
synonym: "beta-cyanoalanine synthetase activity" RELATED [EC:4.4.1.9]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" RELATED [EC:4.4.1.9]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" RELATED [EC:4.4.1.9]
xref: EC:4.4.1.9
xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN
xref: RHEA:17821
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050018
name: L-amino-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5]
synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.5]
xref: EC:1.4.1.5
xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN
xref: RHEA:10396
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050019
name: L-arabinitol 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + H+ + NADH." [EC:1.1.1.12, RHEA:16381]
xref: EC:1.1.1.12
xref: KEGG_REACTION:R01903
xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN
xref: RHEA:16381
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050020
name: L-arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O." [EC:4.2.1.25, RHEA:20968]
synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" RELATED [EC:4.2.1.25]
synonym: "L-arabinonate hydro-lyase activity" RELATED [EC:4.2.1.25]
synonym: "L-arabonate dehydrase activity" RELATED [EC:4.2.1.25]
synonym: "L-arabonate dehydratase activity" RELATED [EC:4.2.1.25]
xref: EC:4.2.1.25
xref: KEGG_REACTION:R02522
xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN
xref: RHEA:20968
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050021
name: L-arabinonolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate + H+." [EC:3.1.1.15, RHEA:16217]
synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.15]
xref: EC:3.1.1.15
xref: KEGG_REACTION:R02526
xref: MetaCyc:L-ARABINONOLACTONASE-RXN
xref: RHEA:16217
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050022
name: L-arabinose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN]
synonym: "L-arabinose 1-dehydrogenase activity" BROAD []
synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.46]
xref: EC:1.1.1.46
xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN
xref: RHEA:17925
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050023
name: L-fuconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O." [EC:4.2.1.68, RHEA:22772]
synonym: "L-fuconate hydratase activity" EXACT []
synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" RELATED [EC:4.2.1.68]
synonym: "L-fuconate hydro-lyase activity" RELATED [EC:4.2.1.68]
xref: EC:4.2.1.68
xref: KEGG_REACTION:R03688
xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN
xref: RHEA:22772
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050024
name: L-galactonolactone oxidase activity
namespace: molecular_function
alt_id: GO:0033733
def: "Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H+." [EC:1.3.3.12, RHEA:20617]
synonym: "L-galactono-1,4-lactone oxidase activity" RELATED [EC:1.3.3.12]
synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" RELATED [EC:1.3.3.12]
synonym: "L-xylono-1,4-lactone oxidase activity" RELATED [EC:1.3.3.12]
xref: EC:1.3.3.12
xref: KEGG_REACTION:R00643
xref: MetaCyc:1.3.3.12-RXN
xref: RHEA:20617
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050025
name: L-glutamate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [RHEA:20728]
synonym: "glutamate (acceptor) dehydrogenase activity" RELATED [EC:1.4.3.11]
synonym: "glutamate oxidase activity" RELATED [EC:1.4.3.11]
synonym: "glutamic acid oxidase activity" RELATED [EC:1.4.3.11]
synonym: "glutamic dehydrogenase (acceptor)" RELATED [EC:1.4.3.11]
synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.11]
synonym: "L-glutamic acid oxidase activity" RELATED [EC:1.4.3.11]
xref: EC:1.4.3.11
xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN
xref: RHEA:20728
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0050026
name: L-glycol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN]
synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" RELATED [EC:1.1.1.185]
synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" RELATED [EC:1.1.1.185]
synonym: "L-glycol:NAD(P) dehydrogenase activity" RELATED [EC:1.1.1.185]
synonym: "L-glycol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.185]
xref: EC:1.1.1.185
xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050027
name: obsolete L-idonate 2-dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN]
comment: This term was made obsolete because EC:1.1.1.128 was deleted: the reaction described is covered by EC:1.1.1.264.
synonym: "5-keto-D-gluconate 2-reductase activity" RELATED [EC:1.1.1.128]
synonym: "5-ketogluconate 2-reductase activity" RELATED [EC:1.1.1.128]
synonym: "5-ketoglucono-idono-reductase activity" RELATED [EC:1.1.1.128]
synonym: "5KGR" RELATED [EC:1.1.1.128]
synonym: "L-idonate 2-dehydrogenase activity" EXACT []
synonym: "L-idonate dehydrogenase activity" RELATED [EC:1.1.1.128]
synonym: "L-idonate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.128]
synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" RELATED [EC:1.1.1.128]
is_obsolete: true
consider: GO:0050572

[Term]
id: GO:0050028
name: L-lysine-lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexano-6-lactam + H2O = L-lysine." [EC:3.5.2.11, RHEA:21388]
synonym: "L-alpha-aminocaprolactam hydrolase activity" RELATED [EC:3.5.2.11]
synonym: "L-lysinamidase activity" RELATED [EC:3.5.2.11]
synonym: "L-lysine-1,6-lactam lactamhydrolase activity" RELATED [EC:3.5.2.11]
xref: EC:3.5.2.11
xref: KEGG_REACTION:R00463
xref: MetaCyc:L-LYSINE-LACTAMASE-RXN
xref: RHEA:21388
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050029
name: L-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-lysine + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4+." [RHEA:14437]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "L-lysine alpha-oxidase activity" RELATED [EC:1.4.3.14]
synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" RELATED [EC:1.4.3.14]
synonym: "L-lysyl-alpha-oxidase activity" RELATED [EC:1.4.3.14]
xref: EC:1.4.3.14
xref: KEGG_REACTION:R00447
xref: MetaCyc:L-LYSINE-OXIDASE-RXN
xref: RHEA:14437
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0050030
name: L-pipecolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN]
synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" RELATED [EC:1.5.99.3]
synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" RELATED [EC:1.5.99.3]
xref: EC:1.5.99.3
xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN
xref: RHEA:19777
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050031
name: L-pipecolate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.3.7, RHEA:11992]
synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" RELATED [EC:1.5.3.7]
synonym: "L-pipecolic acid oxidase activity" RELATED [EC:1.5.3.7]
xref: EC:1.5.3.7
xref: KEGG_REACTION:R02204
xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN
xref: Reactome:R-HSA-6783880 "PIPOX oxidises PPCA to P6C"
xref: RHEA:11992
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050032
name: L-rhamnonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O." [EC:4.2.1.90, RHEA:23080]
synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" RELATED [EC:4.2.1.90]
synonym: "L-rhamnonate hydro-lyase activity" RELATED [EC:4.2.1.90]
xref: EC:4.2.1.90
xref: KEGG_REACTION:R03774
xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN
xref: RHEA:23080
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050033
name: L-rhamnono-1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H+." [EC:3.1.1.65, RHEA:10288]
synonym: "L-rhamno-gamma-lactonase activity" RELATED [EC:3.1.1.65]
synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.65]
synonym: "L-rhamnono-gamma-lactonase activity" RELATED [EC:3.1.1.65]
xref: EC:3.1.1.65
xref: KEGG_REACTION:R03772
xref: MetaCyc:L-RHAMNONO-14-LACTONASE-RXN
xref: RHEA:10288
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050034
name: L-rhamnose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamnono-1,4-lactone + H+ + NADH." [EC:1.1.1.173, RHEA:12649]
synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.173]
xref: EC:1.1.1.173
xref: KEGG_REACTION:R03942
xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN
xref: RHEA:12649
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050035
name: L-sorbose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2." [EC:1.1.3.11, RHEA:17853]
synonym: "L-sorbose:oxygen 5-oxidoreductase activity" RELATED [EC:1.1.3.11]
xref: EC:1.1.3.11
xref: KEGG_REACTION:R01695
xref: MetaCyc:L-SORBOSE-OXIDASE-RXN
xref: RHEA:17853
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050036
name: L-threonate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + H+ + NADH." [EC:1.1.1.129, RHEA:23376]
synonym: "L-threonate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.129]
synonym: "L-threonic acid dehydrogenase activity" RELATED [EC:1.1.1.129]
synonym: "threonate dehydrogenase activity" RELATED [EC:1.1.1.129]
xref: EC:1.1.1.129
xref: KEGG_REACTION:R03733
xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN
xref: RHEA:23376
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050037
name: L-xylose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-xylose + NADP+ = H+ + L-xylono-1,4-lactone + NADPH." [RHEA:15789]
synonym: "L-xylose dehydrogenase activity" RELATED [EC:1.1.1.113]
synonym: "L-xylose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.113]
synonym: "NADPH-xylose reductase activity" RELATED [EC:1.1.1.113]
xref: EC:1.1.1.113
xref: KEGG_REACTION:R03586
xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN
xref: RHEA:15789
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050038
name: L-xylulose reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH." [RHEA:17025]
synonym: "L-xylulose reductase activity" BROAD []
xref: EC:1.1.1.10
xref: KEGG_REACTION:R01904
xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN
xref: Reactome:R-HSA-5661240 "DCXR tetramer reduces L-xylulose to xylitol"
xref: Reactome:R-HSA-5662851 "Defective DCXR does not reduce L-xylulose to xylitol"
xref: RHEA:17025
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050039
name: lactaldehyde reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + propane-1,2-diol = (S)-lactaldehyde + H+ + NADPH." [RHEA:15885]
synonym: "1,2-propanediol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.55]
synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.1.1.55]
synonym: "NADP-1,2-propanediol dehydrogenase activity" RELATED [EC:1.1.1.55]
synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.55]
synonym: "propanediol dehydrogenase activity" RELATED [EC:1.1.1.55]
xref: EC:1.1.1.55
xref: KEGG_REACTION:R02259
xref: MetaCyc:RXN-15744
xref: RHEA:15885
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050040
name: lactate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O." [EC:1.13.12.4, RHEA:16513]
synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.4]
synonym: "L-lactate monooxygenase activity" RELATED [EC:1.13.12.4]
synonym: "L-lactate-2-monooxygenase activity" RELATED [EC:1.13.12.4]
synonym: "lactate monooxygenase activity" RELATED [EC:1.13.12.4]
synonym: "lactate oxidase activity" RELATED [EC:1.13.12.4]
synonym: "lactate oxidative decarboxylase activity" RELATED [EC:1.13.12.4]
synonym: "lactate oxygenase activity" RELATED [EC:1.13.12.4]
synonym: "lactic oxidase activity" RELATED [EC:1.13.12.4]
synonym: "lactic oxygenase activity" RELATED [EC:1.13.12.4]
xref: EC:1.13.12.4
xref: KEGG_REACTION:R00319
xref: MetaCyc:RXN-19631
xref: RHEA:16513
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050041
name: lactate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate = acetaldehyde + formate." [EC:4.1.2.36, RHEA:17909]
synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" RELATED [EC:4.1.2.36]
synonym: "(S)-lactate acetaldehyde-lyase activity" RELATED [EC:4.1.2.36]
synonym: "lactate synthase activity" RELATED [EC:4.1.2.36]
xref: EC:4.1.2.36
xref: KEGG_REACTION:R00753
xref: MetaCyc:LACTATE-ALDOLASE-RXN
xref: RHEA:17909
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050042
name: lactate-malate transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate." [EC:1.1.99.7, RHEA:10984]
synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" RELATED [EC:1.1.99.7]
synonym: "malate-lactate transhydrogenase activity" RELATED [EC:1.1.99.7]
xref: EC:1.1.99.7
xref: KEGG_REACTION:R01447
xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN
xref: RHEA:10984
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050043
name: lactate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, RHEA:10960]
synonym: "hydroxyacid racemase activity" RELATED [EC:5.1.2.1]
synonym: "lactic acid racemase activity" RELATED [EC:5.1.2.1]
synonym: "lacticoracemase activity" RELATED [EC:5.1.2.1]
xref: EC:5.1.2.1
xref: KEGG_REACTION:R01450
xref: MetaCyc:LACTATE-RACEMASE-RXN
xref: RHEA:10960
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0050044
name: galactose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, RHEA:13033]
synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.26]
synonym: "D-galactose-6-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.26]
xref: EC:5.3.1.26
xref: KEGG_REACTION:R03240
xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN
xref: RHEA:13033
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050045
name: laminaribiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31]
synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.31]
xref: EC:2.4.1.31
xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN
xref: RHEA:16617
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050046
name: delta7-sterol 5(6)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O." [RHEA:54320]
synonym: "5-DES" RELATED [EC:1.14.19.20]
synonym: "delta7-sterol 5-desaturase activity" RELATED []
synonym: "delta7-sterol delta5-dehydrogenase activity" RELATED [EC:1.14.19.20]
synonym: "delta7-sterol-C5(6)-desaturase activity" RELATED [EC:1.14.19.20]
synonym: "lathosterol 5-desaturase activity" RELATED [EC:1.14.19.20]
synonym: "lathosterol oxidase activity" EXACT []
xref: EC:1.14.19.20
xref: MetaCyc:RXN-16378
xref: RHEA:54320
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0050047
name: L-leucine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine = (3R)-beta-leucine." [RHEA:10284]
synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" RELATED [EC:5.4.3.7]
synonym: "leucine 2,3-aminomutase activity" RELATED []
xref: EC:5.4.3.7
xref: KEGG_REACTION:R01091
xref: MetaCyc:LEUCINE-23-AMINOMUTASE-RXN
xref: RHEA:10284
is_a: GO:0016869 ! intramolecular aminotransferase activity

[Term]
id: GO:0050048
name: obsolete L-leucine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [GOC:curators]
comment: This term was obsoleted because it represents the same activity L-leucine transaminase activity ; GO:0052654.
is_obsolete: true
replaced_by: GO:0052654

[Term]
id: GO:0050049
name: L-leucine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9]
synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.9]
synonym: "L-leucine:NAD+ oxidoreductase, deaminating" RELATED [EC:1.4.1.9]
synonym: "leucine dehydrogenase activity" RELATED []
synonym: "LeuDH activity" RELATED [EC:1.4.1.9]
xref: EC:1.4.1.9
xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN
xref: RHEA:12220
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050050
name: L-leucine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+." [EC:2.3.1.66, RHEA:20089]
synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" RELATED [EC:2.3.1.66]
synonym: "leucine acetyltransferase activity" RELATED [EC:2.3.1.66]
xref: EC:2.3.1.66
xref: KEGG_REACTION:R01089
xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:20089
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0050051
name: leukotriene-B4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [PMID:11461919, PMID:15364545, PMID:8486631, PMID:9675028, RHEA:22176]
synonym: "leukotriene-B4 20-hydroxylase activity" RELATED [EC:1.14.14.94]
synonym: "leukotriene-B4 omega-hydroxylase activity" RELATED [EC:1.14.14.94]
synonym: "LTB(4) 20-hydroxylase activity" RELATED [EC:1.14.14.94]
synonym: "LTB(4) omega-hydroxylase activity" RELATED [EC:1.14.14.94]
synonym: "LTB4 20-hydroxylase activity" RELATED [EC:1.14.14.94]
synonym: "LTB4 omega-hydroxylase activity" RELATED [EC:1.14.14.94]
xref: EC:1.14.14.94
xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-211873 "CYP4F2, 4F3 20-hydroxylate LTB4"
xref: RHEA:22176
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050052
name: leukotriene-E4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + leukotriene E(4) + NADPH + O2 = 20-hydroxy-leukotriene E(4) + H2O + NADP+." [EC:1.14.13.34, RHEA:24120]
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" RELATED [EC:1.14.13.34]
synonym: "leukotriene-E(4) omega-hydroxylase activity" RELATED [EC:1.14.13.34]
synonym: "leukotriene-E4 omega-hydroxylase activity" RELATED [EC:1.14.13.34]
synonym: "leukotriene-E4 w-hydroxylase activity" EXACT []
xref: EC:1.14.13.34
xref: KEGG_REACTION:R04256
xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN
xref: RHEA:24120
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050053
name: levansucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN]
synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" RELATED [EC:2.4.1.10]
synonym: "beta-2,6-fructosyltransferase activity" RELATED [EC:2.4.1.10]
synonym: "sucrose 6-fructosyl transferase activity" RELATED [EC:2.4.1.10]
synonym: "sucrose 6-fructosyltransferase activity" RELATED [EC:2.4.1.10]
synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.10]
xref: EC:2.4.1.10
xref: MetaCyc:LEVANSUCRASE-RXN
xref: RHEA:13653
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050054
name: lignostilbene alpha beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin." [EC:1.13.11.43, RHEA:21340]
synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" RELATED [EC:1.13.11.43]
synonym: "lignostilbene ab-dioxygenase activity" EXACT []
synonym: "lignostilbene alphabeta-dioxygenase activity" RELATED [EC:1.13.11.43]
xref: EC:1.13.11.43
xref: KEGG_REACTION:R00043
xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN
xref: RHEA:21340
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050055
name: limonin-D-ring-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN]
synonym: "limonin lactone hydrolase activity" RELATED [EC:3.1.1.36]
synonym: "limonin-D-ring-lactone hydrolase activity" RELATED [EC:3.1.1.36]
synonym: "limonoate-D-ring-lactone lactonohydrolase activity" RELATED [EC:3.1.1.36]
xref: EC:3.1.1.36
xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN
xref: RHEA:10896
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050056
name: linalool 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H+ + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]." [RHEA:32635]
synonym: "linalool,[reduced NADPH--hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) activity" RELATED [EC:1.14.14.84]
xref: EC:1.14.14.84
xref: KEGG_REACTION:R04366
xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN
xref: RHEA:32635
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050057
name: linamarin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN]
synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.63]
synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.63]
synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.63]
synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" RELATED [EC:2.4.1.63]
synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" RELATED [EC:2.4.1.63]
synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.63]
synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" RELATED [EC:2.4.1.63]
xref: EC:2.4.1.63
xref: MetaCyc:LINAMARIN-SYNTHASE-RXN
xref: RHEA:20009
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050058
name: linoleate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, RHEA:17381]
synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" RELATED [EC:5.2.1.5]
synonym: "linoleic acid isomerase activity" RELATED [EC:5.2.1.5]
xref: EC:5.2.1.5
xref: KEGG_REACTION:R03627
xref: MetaCyc:LINOLEATE-ISOMERASE-RXN
xref: RHEA:17381
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050059
name: lombricine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN]
synonym: "ATP:lombricine N-phosphotransferase activity" RELATED [EC:2.7.3.5]
xref: EC:2.7.3.5
xref: MetaCyc:LOMBRICINE-KINASE-RXN
xref: RHEA:23292
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050060
name: long-chain-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN]
synonym: "fatty alcohol oxidoreductase activity" RELATED [EC:1.1.1.192]
synonym: "long-chain alcohol dehydrogenase activity" RELATED [EC:1.1.1.192]
synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.192]
xref: EC:1.1.1.192
xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN
xref: RHEA:17977
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050061
name: long-chain fatty aldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain fatty aldehyde + H2O + NAD+ = a long-chain fatty acid + 2 H+ + NADH." [RHEA:10652]
synonym: "fatty aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.48]
synonym: "long-chain aliphatic aldehyde dehydrogenase activity" RELATED [EC:1.2.1.48]
synonym: "long-chain fatty aldehyde dehydrogenase activity" RELATED [EC:1.2.1.48]
synonym: "long-chain-aldehyde dehydrogenase activity" EXACT []
synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.48]
xref: EC:1.2.1.48
xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:10652
xref: UM-BBD_reactionID:r1404
is_a: GO:0102673 ! fatty aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0050062
name: long-chain-fatty-acyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain fatty aldehyde + CoA + NADP+ = a long-chain fatty acyl-CoA + NADPH." [RHEA:15437]
synonym: "acyl coenzyme A reductase activity" RELATED [EC:1.2.1.50]
synonym: "long-chain fatty acyl CoA reductase activity" EXACT []
synonym: "long-chain fatty acyl-CoA reductase activity" EXACT []
xref: EC:1.2.1.50
xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
xref: RHEA:15437
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050063
name: obsolete low-density-lipoprotein particle receptor kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [GOC:curators]
comment: This term was made obsolete because it represents a specific gene product.
synonym: "[low-density lipoprotein receptor] kinase activity" EXACT []
synonym: "low-density-lipoprotein receptor kinase activity" EXACT [GOC:dph]
is_obsolete: true

[Term]
id: GO:0050064
name: luteolin 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.189, RHEA:10568]
synonym: "LGT" RELATED [EC:2.4.1.189]
synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT []
synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.189]
synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.189]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.189]
xref: EC:2.4.1.189
xref: KEGG_REACTION:R03589
xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN
xref: RHEA:10568
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050065
name: lysine-pyruvate 6-transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine." [EC:2.6.1.71, RHEA:19393]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "L-lysine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.71]
synonym: "Lys-AT" RELATED [EC:2.6.1.71]
synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT []
synonym: "lysine-pyruvate aminotransferase activity" RELATED [EC:2.6.1.71]
xref: EC:2.6.1.71
xref: KEGG_REACTION:R00453
xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN
xref: RHEA:19393
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050066
name: L-lysine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [RHEA:19177]
synonym: "lysine 2,3-aminomutase activity" RELATED []
xref: EC:5.4.3.2
xref: KEGG_REACTION:R00461
xref: MetaCyc:LYSINE-23-AMINOMUTASE-RXN
xref: RHEA:19177
is_a: GO:0016869 ! intramolecular aminotransferase activity

[Term]
id: GO:0050067
name: lysine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O." [EC:1.13.12.2, RHEA:14601]
synonym: "L-lysine-2-monooxygenase activity" RELATED [EC:1.13.12.2]
synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.2]
synonym: "lysine monooxygenase activity" RELATED [EC:1.13.12.2]
synonym: "lysine oxygenase activity" RELATED [EC:1.13.12.2]
xref: EC:1.13.12.2
xref: KEGG_REACTION:R00449
xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN
xref: RHEA:14601
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050068
name: lysine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H+ + phosphate." [EC:2.1.3.8, RHEA:17121]
synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" RELATED [EC:2.1.3.8]
synonym: "lysine transcarbamylase activity" RELATED [EC:2.1.3.8]
xref: EC:2.1.3.8
xref: KEGG_REACTION:R01396
xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN
xref: RHEA:17121
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050069
name: lysine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN]
synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" RELATED [EC:1.4.1.15]
xref: EC:1.4.1.15
xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN
xref: RHEA:18505
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050070
name: lysolecithin acylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine." [EC:5.4.1.1, RHEA:24356]
synonym: "lysolecithin 2,3-acylmutase activity" RELATED [EC:5.4.1.1]
synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1]
xref: EC:5.4.1.1
xref: KEGG_REACTION:R03334
xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN
xref: RHEA:24356
is_a: GO:0016867 ! intramolecular acyltransferase activity

[Term]
id: GO:0050071
name: phosphatidylglycerol lysyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)." [EC:2.3.2.3]
synonym: "lysylphosphatidylglycerol synthase activity" EXACT []
synonym: "lysyltransferase activity" BROAD []
xref: EC:2.3.2.3
xref: MetaCyc:LYSYLTRANSFERASE-RXN
xref: RHEA:10668
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0050072
name: obsolete m7G(5')pppN diphosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [GOC:curators]
comment: This term was obsoleted because the obsoleted EC was obsoleted.
synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT []
is_obsolete: true
consider: GO:0140932
consider: GO:0140933

[Term]
id: GO:0050073
name: macrolide 2'-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H+ + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, RHEA:18333]
synonym: "ATP:macrolide 2'-O-phosphotransferase activity" RELATED [EC:2.7.1.136]
xref: EC:2.7.1.136
xref: KEGG_REACTION:R03780
xref: MetaCyc:MACROLIDE-2-KINASE-RXN
xref: RHEA:18333
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050074
name: malate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN]
synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9]
synonym: "malate:CoA ligase (ADP-forming)" RELATED [EC:6.2.1.9]
synonym: "malyl coenzyme A synthetase activity" RELATED [EC:6.2.1.9]
synonym: "malyl-CoA synthetase activity" RELATED [EC:6.2.1.9]
xref: EC:6.2.1.9
xref: MetaCyc:MALATE--COA-LIGASE-RXN
xref: RHEA:26193
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050075
name: maleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-malate = H2O + maleate." [EC:4.2.1.31, RHEA:23692]
synonym: "(R)-malate hydro-lyase (maleate-forming)" RELATED [EC:4.2.1.31]
synonym: "(R)-malate hydro-lyase activity" RELATED [EC:4.2.1.31]
synonym: "D-malate hydro-lyase activity" RELATED [EC:4.2.1.31]
synonym: "malease activity" RELATED [EC:4.2.1.31]
xref: EC:4.2.1.31
xref: KEGG_REACTION:R02419
xref: MetaCyc:MALEATE-HYDRATASE-RXN
xref: RHEA:23692
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050076
name: maleate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, RHEA:13169]
synonym: "maleate cis-trans-isomerase activity" RELATED [EC:5.2.1.1]
xref: EC:5.2.1.1
xref: KEGG_REACTION:R01087
xref: MetaCyc:MALEATE-ISOMERASE-RXN
xref: RHEA:13169
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050077
name: maleylpyruvate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN]
synonym: "3-maleylpyruvate cis-trans-isomerase activity" RELATED [EC:5.2.1.4]
xref: EC:5.2.1.4
xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN
xref: RHEA:17393
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050078
name: malonate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, RHEA:18817]
synonym: "acetyl-CoA:malonate CoA-transferase activity" RELATED [EC:2.8.3.3]
synonym: "malonate coenzyme A-transferase activity" RELATED [EC:2.8.3.3]
xref: EC:2.8.3.3
xref: KEGG_REACTION:R00743
xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN
xref: RHEA:18817
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0050079
name: acetylenecarboxylate hydratase activity
namespace: molecular_function
alt_id: GO:0047607
def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [RHEA:17957]
synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" RELATED [EC:4.2.1.27]
synonym: "3-oxopropanoate hydro-lyase activity" RELATED [EC:4.2.1.27]
synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" NARROW []
synonym: "acetylenemonocarboxylate hydrase activity" RELATED [EC:4.2.1.27]
synonym: "acetylenemonocarboxylate hydratase activity" BROAD []
synonym: "acetylmonocarboxylic acid hydrase activity" RELATED [EC:4.2.1.27]
synonym: "alkynoate hydratase activity" BROAD []
synonym: "malonate-semialdehyde dehydratase activity" RELATED []
xref: EC:4.2.1.27
xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN
xref: RHEA:17957
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050080
name: malonyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]
synonym: "malonyl coenzyme A decarboxylase activity" RELATED [EC:4.1.1.9]
synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.1.9]
synonym: "malonyl-CoA carboxy-lyase activity" RELATED [EC:4.1.1.9]
xref: EC:4.1.1.9
xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN
xref: Reactome:R-HSA-977317 "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome"
xref: RHEA:18781
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050081
name: maltose-6'-phosphate glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN]
synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" RELATED [EC:3.2.1.122]
synonym: "phospho-alpha-glucosidase activity" RELATED [EC:3.2.1.122]
xref: EC:3.2.1.122
xref: MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN
xref: RHEA:20421
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0050082
name: maltose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN]
synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.8]
xref: EC:2.4.1.8
xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN
xref: RHEA:21116
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0050083
name: malyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN]
synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.24]
synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" RELATED [EC:4.1.3.24]
synonym: "malyl-coenzyme A lyase activity" RELATED [EC:4.1.3.24]
xref: MetaCyc:MALYL-COA-LYASE-RXN
xref: RHEA:16629
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0050084
name: mannitol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate." [EC:3.1.3.22, RHEA:19537]
synonym: "D-mannitol-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.22]
synonym: "mannitol-1-phosphate phosphatase activity" RELATED [EC:3.1.3.22]
xref: EC:3.1.3.22
xref: KEGG_REACTION:R02167
xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN
xref: RHEA:19537
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050085
name: mannitol 2-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + H+ + NADPH." [EC:1.1.1.138, RHEA:16765]
synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.138]
synonym: "NADP-dependent mannitol dehydrogenase activity" RELATED [EC:1.1.1.138]
xref: EC:1.1.1.138
xref: KEGG_REACTION:R00870
xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN
xref: RHEA:16765
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050086
name: mannitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN]
synonym: "D-mannitol dehydrogenase activity" RELATED [EC:1.1.1.67]
synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.67]
xref: EC:1.1.1.67
xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN
xref: RHEA:12084
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050087
name: mannitol dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+." [RHEA:17597]
synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" RELATED []
synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2]
xref: EC:1.1.2.2
xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN
xref: RHEA:17597
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0050088
name: mannose-6-phosphate 6-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH." [EC:1.1.1.224, RHEA:14925]
synonym: "6-phosphomannose reductase activity" RELATED [EC:1.1.1.224]
synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" RELATED [EC:1.1.1.224]
synonym: "mannose-6-phosphate reductase activity" RELATED [EC:1.1.1.224]
synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" RELATED [EC:1.1.1.224]
synonym: "NADPH-dependent M6P reductase activity" RELATED [EC:1.1.1.224]
synonym: "NADPH-dependent mannose 6-phosphate reductase activity" RELATED [EC:1.1.1.224]
synonym: "NADPH-mannose-6-P reductase activity" RELATED [EC:1.1.1.224]
xref: EC:1.1.1.224
xref: KEGG_REACTION:R01817
xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN
xref: RHEA:14925
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050089
name: mannose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannose = D-fructose." [RHEA:22604]
synonym: "D-mannose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.7]
synonym: "D-mannose isomerase activity" RELATED [EC:5.3.1.7]
synonym: "D-mannose ketol-isomerase activity" RELATED [EC:5.3.1.7]
xref: EC:5.3.1.7
xref: KEGG_REACTION:R00877
xref: MetaCyc:MANNOSE-ISOMERASE-RXN
xref: RHEA:22604
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050090
name: mannuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN]
synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" RELATED [EC:1.1.1.131]
synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" RELATED [EC:1.1.1.131]
synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" RELATED [EC:1.1.1.131]
synonym: "mannonate dehydrogenase (NAD(P)+)" RELATED [EC:1.1.1.131]
synonym: "mannonate dehydrogenase activity" RELATED [EC:1.1.1.131]
xref: EC:1.1.1.131
xref: MetaCyc:MANNURONATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050091
name: melilotate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H+ + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+." [EC:1.14.13.4, RHEA:17669]
synonym: "2-hydroxyphenylpropionate hydroxylase activity" RELATED [EC:1.14.13.4]
synonym: "2-hydroxyphenylpropionic hydroxylase activity" RELATED [EC:1.14.13.4]
synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.4]
synonym: "melilotate hydroxylase activity" EXACT []
synonym: "melilotic hydroxylase activity" RELATED [EC:1.14.13.4]
xref: EC:1.14.13.4
xref: KEGG_REACTION:R03369
xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN
xref: RHEA:17669
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050092
name: meso-tartrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-tartrate + NAD+ = dihydroxyfumarate + H+ + NADH." [EC:1.3.1.7, RHEA:18553]
synonym: "meso-tartrate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.7]
xref: EC:1.3.1.7
xref: KEGG_REACTION:R02544
xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN
xref: RHEA:18553
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050093
name: methanol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: methanol + NAD+ = formaldehyde + H+ + NADH." [EC:1.1.1.244, RHEA:19401]
synonym: "methanol dehydrogenase activity" BROAD []
synonym: "methanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.244]
xref: EC:1.1.1.244
xref: KEGG_REACTION:R00605
xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN
xref: RHEA:19401
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0050094
name: methionine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, RHEA:22884]
synonym: "L-methionine:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.73]
synonym: "methionine-glyoxylate aminotransferase activity" RELATED [EC:2.6.1.73]
synonym: "MGAT activity" RELATED [EC:2.6.1.73]
xref: EC:2.6.1.73
xref: KEGG_REACTION:R00652
xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN
xref: RHEA:22884
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050095
name: methionine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + H+ = 3-methylthiopropanamine + CO2." [EC:4.1.1.57, RHEA:17757]
synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" RELATED [EC:4.1.1.57]
synonym: "L-methionine carboxy-lyase activity" RELATED [EC:4.1.1.57]
synonym: "L-methionine decarboxylase activity" RELATED [EC:4.1.1.57]
xref: EC:4.1.1.57
xref: KEGG_REACTION:R00656
xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN
xref: RHEA:17757
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050096
name: methylaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH4." [EC:4.3.1.2, RHEA:12829]
synonym: "3-methylaspartase activity" RELATED [EC:4.3.1.2]
synonym: "beta-methylaspartase activity" RELATED [EC:4.3.1.2]
synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" RELATED [EC:4.3.1.2]
synonym: "L-threo-3-methylaspartate ammonia-lyase activity" RELATED [EC:4.3.1.2]
xref: EC:4.3.1.2
xref: KEGG_REACTION:R03696
xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN
xref: RHEA:12829
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0050097
name: methylaspartate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate." [EC:5.4.99.1, RHEA:12857]
synonym: "b-methylaspartate-glutamate mutase activity" RELATED [EC:5.4.99.1]
synonym: "beta-methylaspartate-glutamate mutase activity" RELATED [EC:5.4.99.1]
synonym: "glutamate isomerase activity" RELATED [EC:5.4.99.1]
synonym: "glutamate mutase activity" RELATED [EC:5.4.99.1]
synonym: "glutamic acid isomerase activity" RELATED [EC:5.4.99.1]
synonym: "glutamic acid mutase activity" RELATED [EC:5.4.99.1]
synonym: "glutamic isomerase activity" RELATED [EC:5.4.99.1]
synonym: "glutamic mutase activity" RELATED [EC:5.4.99.1]
synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" RELATED [EC:5.4.99.1]
synonym: "methylaspartic acid mutase activity" RELATED [EC:5.4.99.1]
xref: EC:5.4.99.1
xref: KEGG_REACTION:R00262
xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN
xref: RHEA:12857
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050098
name: methylguanidinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea." [EC:3.5.3.16, RHEA:11764]
synonym: "methylguanidine amidinohydrolase activity" RELATED [EC:3.5.3.16]
synonym: "methylguanidine hydrolase activity" RELATED [EC:3.5.3.16]
xref: EC:3.5.3.16
xref: KEGG_REACTION:R01589
xref: MetaCyc:METHYLGUANIDINASE-RXN
xref: RHEA:11764
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050099
name: methylglutamate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-L-glutamate + A + H2O = L-glutamate + AH(2) + formaldehyde." [EC:1.5.99.5, RHEA:22572]
synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" RELATED [EC:1.5.99.5]
synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" RELATED [EC:1.5.99.5]
synonym: "N-methylglutamate dehydrogenase activity" RELATED [EC:1.5.99.5]
xref: EC:1.5.99.5
xref: KEGG_REACTION:R00609
xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN
xref: RHEA:22572
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050100
name: methylitaconate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate." [RHEA:23480]
synonym: "methylitaconate D-isomerase activity" EXACT []
synonym: "methylitaconate delta2-delta3-isomerase activity" RELATED [EC:5.3.3.6]
synonym: "methylitaconate isomerase activity" RELATED [EC:5.3.3.6]
xref: EC:5.3.3.6
xref: KEGG_REACTION:R03070
xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN
xref: RHEA:23480
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050101
name: mimosinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-mimosine + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine." [GOC:curators, RHEA:75355]
synonym: "mimosine amidohydrolase activity" RELATED []
xref: EC:4.3.3.8
xref: KEGG_REACTION:R04350
xref: MetaCyc:MIMOSINASE-RXN
xref: RHEA:75355
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0050102
name: cellodextrin phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN]
synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.49]
synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" RELATED [EC:2.4.1.49]
xref: EC:2.4.1.49
xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN
xref: RHEA:23024
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050103
name: dextrin dextranase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN]
synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.2]
synonym: "dextran dextrinase activity" RELATED [EC:2.4.1.2]
synonym: "dextrin 6-glucosyltransferase activity" RELATED [EC:2.4.1.2]
xref: EC:2.4.1.2
xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN
xref: RHEA:14625
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050104
name: L-gulonate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH." [EC:1.1.1.45, RHEA:12889]
synonym: "L-3-aldonate dehydrogenase activity" RELATED [EC:1.1.1.45]
synonym: "L-3-aldonic dehydrogenase activity" RELATED [EC:1.1.1.45]
synonym: "L-3-hydroxyacid dehydrogenase activity" RELATED [EC:1.1.1.45]
synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" RELATED [EC:1.1.1.45]
synonym: "L-beta-hydroxyacid dehydrogenase activity" RELATED [EC:1.1.1.45]
synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.45]
synonym: "L-gulonic acid dehydrogenase activity" RELATED [EC:1.1.1.45]
xref: EC:1.1.1.45
xref: KEGG_REACTION:R02640
xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-5661290 "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate"
xref: RHEA:12889
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050105
name: L-gulonolactone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN, RHEA:32363]
synonym: "GLO activity" RELATED [EC:1.1.3.8]
synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" RELATED [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone oxidase activity" RELATED [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" RELATED [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone:oxidoreductase activity" RELATED [EC:1.1.3.8]
xref: EC:1.1.3.8
xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN
xref: RHEA:32363
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050106
name: monomethyl-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + monomethyl sulfate = H+ + methanol + sulfate." [EC:3.1.6.16, RHEA:14221]
synonym: "monomethyl-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.16]
synonym: "monomethyl-sulphatase activity" EXACT []
xref: EC:3.1.6.16
xref: KEGG_REACTION:R01145
xref: MetaCyc:MONOMETHYL-SULFATASE-RXN
xref: RHEA:14221
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0050107
name: monoterpenol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" RELATED [EC:2.3.1.69]
synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69]
xref: EC:2.3.1.69
xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050108
name: monoterpenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,4R)-bornyl diphosphate + H2O = (1R,2S,4R)-borneol + diphosphate." [EC:3.1.7.3, PMID:42357]
synonym: "bornyl diphosphate hydrolase activity" RELATED [EC:3.1.7.3]
synonym: "bornyl pyrophosphate hydrolase activity" RELATED [EC:3.1.7.3]
synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" RELATED [EC:3.1.7.3]
synonym: "monoterpenyl-pyrophosphatase activity" EXACT []
xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050109
name: morphine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN]
synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" RELATED [EC:1.1.1.218]
synonym: "naloxone reductase activity" RELATED [EC:1.1.1.218]
synonym: "reductase, naloxone" RELATED [EC:1.1.1.218]
xref: EC:1.1.1.218
xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050110
name: obsolete endo-alpha-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions : D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine and D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-threonyl + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-threonyl." [GOC:rynl]
comment: The reason for obsoletion is that the term shares the same EC xref as GO:0033926 endo-alpha-N-acetylgalactosaminidase activity.
is_obsolete: true
replaced_by: GO:0033926

[Term]
id: GO:0050111
name: mycocerosate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 7n H+ + n methylmalonyl-CoA + 2n NADPH = n CO2 + n CoA + n H2O + multi-methyl-branched acyl-CoA + 2n NADP+." [EC:2.3.1.111, RHEA:10588]
synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" RELATED [EC:2.3.1.111]
synonym: "mycocerosic acid synthase activity" RELATED [EC:2.3.1.111]
xref: EC:2.3.1.111
xref: KEGG_REACTION:R05189
xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN
xref: RHEA:10588
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050112
name: inositol 2-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH." [EC:1.1.1.18, RHEA:16949]
synonym: "inositol 2-dehydrogenase activity" BROAD []
synonym: "inositol:NAD 2-dehydrogenase activity" EXACT []
synonym: "myo-inositol 2-dehydrogenase activity" EXACT []
xref: EC:1.1.1.18
xref: KEGG_REACTION:R01183
xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN
xref: RHEA:16949
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:0050113
name: inositol oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+." [RHEA:23696]
synonym: "meso-inositol oxygenase activity" RELATED [EC:1.13.99.1]
synonym: "MOO activity" RELATED [EC:1.13.99.1]
synonym: "myo-inositol oxygenase activity" EXACT []
synonym: "myo-inositol:oxygen oxidoreductase activity" RELATED [EC:1.13.99.1]
xref: EC:1.13.99.1
xref: KEGG_REACTION:R01184
xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN
xref: Reactome:R-HSA-5678327 "MIOX oxidises Ins to GlcA"
xref: RHEA:23696
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0050114
name: myo-inosose-2 dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O." [EC:4.2.1.44, RHEA:14065]
synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" RELATED [EC:4.2.1.44]
synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" RELATED [EC:4.2.1.44]
synonym: "inosose 2,3-dehydratase activity" RELATED [EC:4.2.1.44]
synonym: "ketoinositol dehydratase activity" RELATED [EC:4.2.1.44]
xref: EC:4.2.1.44
xref: KEGG_REACTION:R02782
xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN
xref: RHEA:14065
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050115
name: myosin-light-chain-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN]
synonym: "[Myosin light-chain]-phosphatase activity" EXACT []
synonym: "myosin light chain kinase phosphatase activity" RELATED [EC:3.1.3.53]
synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53]
synonym: "myosin-light-chain phosphatase activity" RELATED [EC:3.1.3.53]
synonym: "myosin-light-chain-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.53]
synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53]
xref: EC:3.1.3.53
xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN
xref: Reactome:R-HSA-419232 "Myosin phosphatase dephosphorylates myosin regulatory light chain"
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0050116
name: N,N-dimethylformamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate." [EC:3.5.1.56, RHEA:19517]
synonym: "dimethylformamidase activity" RELATED [EC:3.5.1.56]
synonym: "DMFase activity" RELATED [EC:3.5.1.56]
synonym: "N,N-dimethylformamide amidohydrolase activity" RELATED [EC:3.5.1.56]
xref: EC:3.5.1.56
xref: KEGG_REACTION:R02509
xref: MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN
xref: RHEA:19517
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050117
name: N-acetyl-beta-alanine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-alanine + H2O = beta-alanine + acetate." [EC:3.5.1.21, RHEA:23212]
synonym: "N-acetyl-beta-alanine amidohydrolase activity" RELATED [EC:3.5.1.21]
xref: EC:3.5.1.21
xref: KEGG_REACTION:R00909
xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN
xref: RHEA:23212
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050118
name: N-acetyldiaminopimelate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate." [RHEA:20405]
synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" RELATED [EC:3.5.1.47]
synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" RELATED [EC:3.5.1.47]
synonym: "N-acetyl-LL-diaminopimelate deacylase activity" RELATED [EC:3.5.1.47]
synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" RELATED [EC:3.5.1.47]
xref: EC:3.5.1.47
xref: KEGG_REACTION:R02733
xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN
xref: RHEA:20405
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050119
name: N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate." [EC:3.5.1.33, RHEA:20593]
synonym: "acetylaminodeoxyglucose acetylhydrolase activity" RELATED [EC:3.5.1.33]
synonym: "N-acetyl-D-glucosamine amidohydrolase activity" RELATED [EC:3.5.1.33]
synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" RELATED [EC:3.5.1.33]
xref: EC:3.5.1.33
xref: KEGG_REACTION:R01200
xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN
xref: Reactome:R-HSA-2022887 "NDST1-4 N-deacetylates GlcNAc residues in heparan"
xref: RHEA:20593
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050120
name: N-acetylhexosamine 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + NAD+ = N-acetyl-D-glucosaminate + 2 H+ + NADH." [EC:1.1.1.240, RHEA:23144]
synonym: "N-acetyl-D-hexosamine dehydrogenase activity" RELATED [EC:1.1.1.240]
synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.240]
synonym: "N-acetylhexosamine dehydrogenase activity" RELATED [EC:1.1.1.240]
xref: EC:1.1.1.240
xref: KEGG_REACTION:R01202
xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN
xref: RHEA:23144
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050121
name: N-acylglucosamine 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN]
synonym: "acylglucosamine 2-epimerase activity" RELATED [EC:5.1.3.8]
synonym: "GlcNAc 2-epimerase activity" RELATED [EC:5.1.3.8]
synonym: "N-acetyl-D-glucosamine 2-epimerase activity" RELATED [EC:5.1.3.8]
synonym: "N-acetylglucosamine 2-epimerase activity" RELATED [EC:5.1.3.8]
synonym: "N-acyl-D-glucosamine 2-epimerase activity" RELATED [EC:5.1.3.8]
xref: EC:5.1.3.8
xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN
xref: Reactome:R-HSA-6803761 "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc"
xref: RHEA:19033
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050122
name: N-acylhexosamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + O2 = N-acetyl-D-glucosaminate + H2O2 + H+." [EC:1.1.3.29, RHEA:13029]
synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.29]
synonym: "N-acyl-D-hexosamine oxidase activity" RELATED [EC:1.1.3.29]
synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.29]
xref: EC:1.1.3.29
xref: KEGG_REACTION:R01203
xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN
xref: RHEA:13029
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050123
name: N-acylmannosamine 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + H+ + NADH." [EC:1.1.1.233, RHEA:11540]
synonym: "N-acetyl-D-mannosamine dehydrogenase activity" RELATED [EC:1.1.1.233]
synonym: "N-acyl-D-mannosamine dehydrogenase activity" RELATED [EC:1.1.1.233]
synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.233]
synonym: "N-acylmannosamine dehydrogenase activity" RELATED [EC:1.1.1.233]
xref: EC:1.1.1.233
xref: KEGG_REACTION:R02651
xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN
xref: RHEA:11540
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050124
name: N-acylneuraminate-9-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]
synonym: "acylneuraminate 9-phosphatase activity" RELATED [EC:3.1.3.29]
synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.29]
synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" RELATED [EC:3.1.3.29]
synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" RELATED [EC:3.1.3.29]
xref: EC:3.1.3.29
xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN
xref: Reactome:R-HSA-4084989 "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac"
xref: RHEA:13057
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050125
name: N-benzyloxycarbonylglycine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O + H+ = benzyl alcohol + CO2 + glycine." [EC:3.5.1.58, RHEA:20900]
synonym: "benzyloxycarbonylglycine hydrolase activity" RELATED [EC:3.5.1.58]
synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" RELATED [EC:3.5.1.58]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" RELATED [EC:3.5.1.58]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58]
synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" RELATED [EC:3.5.1.58]
xref: EC:3.5.1.58
xref: KEGG_REACTION:R02551
xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN
xref: RHEA:20900
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050126
name: N-carbamoylputrescine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine." [EC:3.5.1.53, RHEA:22284]
synonym: "carbamoylputrescine hydrolase activity" RELATED [EC:3.5.1.53]
synonym: "N-carbamoylputrescine amidohydrolase activity" RELATED [EC:3.5.1.53]
synonym: "NCP" RELATED [EC:3.5.1.53]
xref: EC:3.5.1.53
xref: KEGG_REACTION:R01152
xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN
xref: RHEA:22284
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050127
name: N-carbamoylsarcosine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoylsarcosine + H2O + 2 H+ = CO2 + NH4 + sarcosine." [EC:3.5.1.59, RHEA:20057]
synonym: "carbamoylsarcosine amidase activity" RELATED [EC:3.5.1.59]
synonym: "CSHase activity" RELATED [EC:3.5.1.59]
synonym: "N-carbamoylsarcosine amidohydrolase activity" RELATED [EC:3.5.1.59]
xref: EC:3.5.1.59
xref: KEGG_REACTION:R01563
xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN
xref: RHEA:20057
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050128
name: N-feruloylglycine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine." [EC:3.5.1.71, RHEA:10484]
synonym: "N-feruloylglycine amidohydrolase activity" RELATED [EC:3.5.1.71]
synonym: "N-feruloylglycine hydrolase activity" RELATED [EC:3.5.1.71]
xref: EC:3.5.1.71
xref: KEGG_REACTION:R03579
xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN
xref: RHEA:10484
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050129
name: N-formylglutamate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate." [EC:3.5.1.68, RHEA:12476]
synonym: "beta-citryl-L-glutamate amidase activity" RELATED [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate hydrolase activity" RELATED [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68]
synonym: "beta-citrylglutamate amidase activity" RELATED [EC:3.5.1.68]
synonym: "formylglutamate deformylase activity" RELATED [EC:3.5.1.68]
synonym: "N-formyl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.68]
synonym: "N-formylglutamate hydrolase activity" RELATED [EC:3.5.1.68]
xref: EC:3.5.1.68
xref: KEGG_REACTION:R00525
xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN
xref: RHEA:12476
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050130
name: N-methyl-2-oxoglutaramate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylammonium." [EC:3.5.1.36, RHEA:24108]
synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" RELATED [EC:3.5.1.36]
synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" RELATED [EC:3.5.1.36]
xref: EC:3.5.1.36
xref: KEGG_REACTION:R01587
xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN
xref: RHEA:24108
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050131
name: N-methyl-L-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2]
synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.2]
synonym: "N-methylamino acid oxidase activity" RELATED [EC:1.5.3.2]
xref: EC:1.5.3.2
xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN
xref: RHEA:11472
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050132
name: N-methylalanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = H+ + methylammonium + NADPH + pyruvate." [EC:1.4.1.17, RHEA:21768]
synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" RELATED [EC:1.4.1.17]
xref: EC:1.4.1.17
xref: KEGG_REACTION:R01584
xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN
xref: RHEA:21768
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050133
name: N6-hydroxylysine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA." [EC:2.3.1.102, RHEA:22388]
synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" RELATED [EC:2.3.1.102]
synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" RELATED [EC:2.3.1.102]
synonym: "N(6)-hydroxylysine acetylase activity" RELATED [EC:2.3.1.102]
synonym: "N6-hydroxylysine acetylase activity" RELATED [EC:2.3.1.102]
synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" RELATED [EC:2.3.1.102]
xref: EC:2.3.1.102
xref: KEGG_REACTION:R03168
xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN
xref: RHEA:22388
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050134
name: N6-methyl-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2." [EC:1.5.3.4, RHEA:23200]
synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.4]
synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.4]
synonym: "epsilon-alkyllysinase activity" RELATED [EC:1.5.3.4]
synonym: "epsilon-N-methyllysine demethylase activity" RELATED [EC:1.5.3.4]
synonym: "N(6)-methyllysine oxidase activity" RELATED [EC:1.5.3.4]
synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.4]
synonym: "N6-methyllysine oxidase activity" RELATED [EC:1.5.3.4]
xref: EC:1.5.3.4
xref: KEGG_REACTION:R00612
xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN
xref: RHEA:23200
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050135
name: NADP+ nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose-2-phosphate + nicotinamide." [RHEA:19849]
synonym: "NAD(P)+ nucleosidase activity" BROAD []
synonym: "NADP nucleosidase activity" EXACT []
synonym: "NADP(+) nucleosidase activity" EXACT []
synonym: "NADP+ glycohydrolase activity" RELATED []
synonym: "NADPase activity" RELATED []
xref: RHEA:19849
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0050136
name: NADH:ubiquinone reductase (non-electrogenic) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.5.9, GOC:mah, RHEA:46160]
synonym: "NADH dehydrogenase (quinone) activity" RELATED []
xref: EC:1.6.5.9
xref: MetaCyc:1.6.99.5-RXN
xref: RHEA:46160
is_a: GO:0003954 ! NADH dehydrogenase activity
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0050137
name: NADPH peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+." [EC:1.11.1.2, RHEA:15173]
synonym: "NADP peroxidase activity" RELATED [EC:1.11.1.2]
synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.2]
synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" RELATED [EC:1.11.1.2]
synonym: "TPN peroxidase activity" RELATED [EC:1.11.1.2]
synonym: "TPNH peroxidase activity" RELATED [EC:1.11.1.2]
synonym: "triphosphopyridine nucleotide peroxidase activity" RELATED [EC:1.11.1.2]
xref: EC:1.11.1.2
xref: KEGG_REACTION:R00113
xref: MetaCyc:NADPH-PEROXIDASE-RXN
xref: RHEA:15173
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0050138
name: nicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NADP+ + nicotinate = 6-hydroxynicotinate + H+ + NADPH." [EC:1.17.1.5, RHEA:12236]
synonym: "nicotinate hydroxylase activity" RELATED [EC:1.17.1.5]
synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" RELATED [EC:1.17.1.5]
synonym: "nicotinic acid hydroxylase activity" RELATED [EC:1.17.1.5]
xref: EC:1.17.1.5
xref: KEGG_REACTION:R01720
xref: MetaCyc:RXN-7637
xref: RHEA:12236
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0050139
name: nicotinate-N-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP." [EC:2.4.1.196, RHEA:19437]
synonym: "nicotinate glucosyltransferase activity" BROAD []
synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" RELATED [EC:2.4.1.196]
synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" RELATED [EC:2.4.1.196]
synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" RELATED [EC:2.4.1.196]
synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" RELATED [EC:2.4.1.196]
xref: EC:2.4.1.196
xref: KEGG_REACTION:R01722
xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:19437
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050140
name: nitrate reductase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite." [RHEA:12909]
synonym: "benzyl viologen-nitrate reductase activity" RELATED [EC:1.9.6.1]
synonym: "ferrocytochrome:nitrate oxidoreductase activity" RELATED [EC:1.9.6.1]
xref: EC:1.9.6.1
xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN
xref: RHEA:12909
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0016677 ! oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor

[Term]
id: GO:0050141
name: obsolete nitroethane oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of nitroalkane oxidase activity ; GO:0052664.
is_obsolete: true
replaced_by: GO:0052664

[Term]
id: GO:0050142
name: nitrogenase (flavodoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN]
synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" RELATED [EC:1.19.6.1]
xref: EC:1.19.6.1
xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN
xref: RHEA:15645
is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor

[Term]
id: GO:0050143
name: nocardicin-A epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isonocardicin A = nocardicin A. May also catalyse the epimerisation of isonocardicin C, but the in vivo substrate appears to be isonocardicin A." [EC:5.1.1.14, RHEA:22792]
synonym: "isonocardicin A epimerase activity" RELATED [EC:5.1.1.14]
xref: EC:5.1.1.14
xref: KEGG_REACTION:R03073
xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN
xref: RHEA:22792
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0050144
name: nucleoside deoxyribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN]
synonym: "deoxyribose transferase activity" RELATED [EC:2.4.2.6]
synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6]
synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6]
synonym: "nucleoside trans-N-deoxyribosylase activity" RELATED [EC:2.4.2.6]
synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" RELATED [EC:2.4.2.6]
synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" RELATED [EC:2.4.2.6]
synonym: "trans-deoxyribosylase activity" RELATED [EC:2.4.2.6]
synonym: "trans-N-deoxyribosylase activity" RELATED [EC:2.4.2.6]
synonym: "trans-N-glycosidase activity" RELATED [EC:2.4.2.6]
xref: EC:2.4.2.6
xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0050145
name: nucleoside monophosphate kinase activity
namespace: molecular_function
alt_id: GO:0019201
def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]
synonym: "ATP:nucleoside-phosphate phosphotransferase activity" RELATED [EC:2.7.4.4]
synonym: "NMP-kinase activity" RELATED [EC:2.7.4.4]
synonym: "nucleoside-phosphate kinase activity" EXACT []
synonym: "nucleotide kinase activity" RELATED []
xref: EC:2.7.4.4
xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN
xref: Reactome:R-HSA-2162092 "carbovir monophosphate + ATP => carbovir diphosphate + ADP"
xref: Reactome:R-HSA-6788798 "AK4 phosphorylates (d)NMPs to (d)NDPs"
xref: Reactome:R-HSA-6788810 "AK6 phosphorylates (d)NMPs to (d)NDPs"
xref: Reactome:R-HSA-73548 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)"
xref: Reactome:R-HSA-73635 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]"
xref: Reactome:R-HSA-75125 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)"
xref: Reactome:R-HSA-75126 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]"
xref: Reactome:R-HSA-9754978 "Unknown kinase phosphorylates RBV-MP"
xref: RHEA:24036
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0050146
name: nucleoside phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN]
synonym: "nonspecific nucleoside phosphotransferase activity" RELATED [EC:2.7.1.77]
synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.77]
synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.77]
synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.77]
xref: EC:2.7.1.77
xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN
xref: Reactome:R-HSA-2162066 "carbovir + IMP => carbovir monophosphate + inosine"
xref: Reactome:R-HSA-9754916 "NT5C2 tetramer phosphorylates RBV"
xref: RHEA:19961
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0050147
name: nucleoside ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN]
synonym: "nucleoside N-ribosyltransferase activity" RELATED [EC:2.4.2.5]
synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" RELATED [EC:2.4.2.5]
xref: EC:2.4.2.5
xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0050148
name: nucleotide diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [RHEA:12713]
synonym: "ATP nucleotide 3'-pyrophosphokinase activity" RELATED [EC:2.7.6.4]
synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" RELATED [EC:2.7.6.4]
synonym: "ATP:nucleotide pyrophosphotransferase activity" RELATED [EC:2.7.6.4]
synonym: "nucleotide 3'-pyrophosphokinase activity" RELATED [EC:2.7.6.4]
synonym: "nucleotide pyrophosphokinase activity" EXACT []
xref: EC:2.7.6.4
xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN
xref: RHEA:12713
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0050149
name: o-aminophenol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN]
synonym: "2-aminophenol:O2 oxidoreductase activity" RELATED [EC:1.10.3.4]
synonym: "2-aminophenol:oxygen oxidoreductase activity" RELATED [EC:1.10.3.4]
synonym: "GriF" RELATED [EC:1.10.3.4]
synonym: "isophenoxazine synthase activity" RELATED [EC:1.10.3.4]
synonym: "o-aminophenol:O2 oxidoreductase activity" RELATED [EC:1.10.3.4]
xref: EC:1.10.3.4
xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN
xref: RHEA:40963
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0050150
name: o-pyrocatechuate decarboxylase activity
namespace: molecular_function
alt_id: GO:0018790
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = catechol + CO2." [EC:4.1.1.46, RHEA:21492]
synonym: "2,3-DHBA decarboxylase activity" RELATED [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" RELATED [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" RELATED [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate decarboxylase activity" EXACT []
synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" RELATED [EC:4.1.1.46]
xref: EC:4.1.1.46
xref: KEGG_REACTION:R00821
xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN
xref: RHEA:21492
xref: UM-BBD_reactionID:r0579
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050151
name: oleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-10-hydroxystearate = H2O + oleate." [EC:4.2.1.53, RHEA:21852]
synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" RELATED [EC:4.2.1.53]
synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" RELATED [EC:4.2.1.53]
xref: EC:4.2.1.53
xref: KEGG_REACTION:R02813
xref: MetaCyc:OLEATE-HYDRATASE-RXN
xref: RHEA:21852
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050152
name: omega-amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]
synonym: "alpha-keto acid-omega-amidase activity" RELATED [EC:3.5.1.3]
synonym: "omega-amidodicarboxylate amidohydrolase activity" RELATED [EC:3.5.1.3]
synonym: "w-amidase activity" EXACT []
xref: EC:3.5.1.3
xref: MetaCyc:OMEGA-AMIDASE-RXN
xref: RHEA:11716
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050153
name: omega-hydroxydecanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH." [EC:1.1.1.66, RHEA:20880]
synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" RELATED [EC:1.1.1.66]
synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT []
xref: EC:1.1.1.66
xref: KEGG_REACTION:R03886
xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN
xref: RHEA:20880
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050154
name: opheline kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H+." [EC:2.7.3.7, RHEA:17553]
synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" RELATED [EC:2.7.3.7]
xref: EC:2.7.3.7
xref: KEGG_REACTION:R04388
xref: MetaCyc:OPHELINE-KINASE-RXN
xref: RHEA:17553
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050155
name: obsolete ornithine(lysine) transaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [GOC:curators]
comment: This term represents the same activity as GO:0004587.
synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT []
synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT []
synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT []
synonym: "ornithine(lysine) aminotransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004587

[Term]
id: GO:0050156
name: ornithine N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H+." [EC:2.3.1.127, RHEA:16929]
synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" RELATED [EC:2.3.1.127]
synonym: "ornithine N-acyltransferase activity" RELATED [EC:2.3.1.127]
xref: EC:2.3.1.127
xref: KEGG_REACTION:R00664
xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN
xref: RHEA:16929
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050157
name: ornithine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12]
xref: EC:5.1.1.12
xref: MetaCyc:ORNITHINE-RACEMASE-RXN
xref: RHEA:11584
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0050158
name: dihydroorotate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + NADP+ = H+ + NADPH + orotate." [RHEA:14861]
synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.15]
synonym: "dihydro-orotic dehydrogenase activity" RELATED [EC:1.3.1.15]
synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" RELATED [EC:1.3.1.15]
synonym: "orotate reductase (NADPH) activity" EXACT []
synonym: "orotate reductase activity" RELATED [EC:1.3.1.15]
xref: EC:1.3.1.15
xref: KEGG_REACTION:R01866
xref: MetaCyc:OROTATE-REDUCTASE-NADPH-RXN
xref: RHEA:14861
is_a: GO:0004152 ! dihydroorotate dehydrogenase activity
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050159
name: orsellinate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: o-orsellinate + H+ = CO2 + orcinol." [EC:4.1.1.58, RHEA:16733]
synonym: "orsellinate carboxy-lyase (orcinol-forming)" RELATED [EC:4.1.1.58]
synonym: "orsellinate carboxy-lyase activity" RELATED [EC:4.1.1.58]
xref: EC:4.1.1.58
xref: KEGG_REACTION:R02831
xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN
xref: RHEA:16733
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050160
name: orsellinate-depside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + orsellinate depside = 2 o-orsellinate + H+." [EC:3.1.1.40, RHEA:19549]
synonym: "lecanorate hydrolase activity" RELATED [EC:3.1.1.40]
xref: EC:3.1.1.40
xref: KEGG_REACTION:R00054
xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN
xref: RHEA:19549
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050161
name: succinyl-CoA:oxalate CoA-transferase
namespace: molecular_function
def: "Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate." [EC:2.8.3.2, RHEA:23588]
synonym: "oxalate CoA-transferase activity" RELATED [EC:2.8.3.2]
synonym: "oxalate coenzyme A-transferase activity" RELATED [EC:2.8.3.2]
synonym: "succinyl-beta-ketoacyl-CoA transferase activity" RELATED [EC:2.8.3.2]
synonym: "succinyl-CoA:oxalate CoA-transferase activity" RELATED [EC:2.8.3.2]
xref: EC:2.8.3.2
xref: KEGG_REACTION:R01559
xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN
xref: RHEA:23588
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0050162
name: oxalate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + O2 + oxalate = 2 CO2 + H2O2." [RHEA:21880]
synonym: "aero-oxalo dehydrogenase activity" RELATED [EC:1.2.3.4]
synonym: "oxalate:oxygen oxidoreductase activity" RELATED [EC:1.2.3.4]
synonym: "oxalic acid oxidase activity" RELATED [EC:1.2.3.4]
xref: EC:1.2.3.4
xref: KEGG_REACTION:R00273
xref: MetaCyc:OXALATE-OXIDASE-RXN
xref: RHEA:21880
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050163
name: oxaloacetate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate." [EC:5.3.2.2, RHEA:16021]
synonym: "oxalacetic keto-enol isomerase activity" RELATED [EC:5.3.2.2]
synonym: "oxaloacetate keto-enol tautomerase activity" RELATED [EC:5.3.2.2]
synonym: "oxaloacetate keto-enol-isomerase activity" RELATED [EC:5.3.2.2]
xref: EC:5.3.2.2
xref: KEGG_REACTION:R00363
xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN
xref: RHEA:16021
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0050164
name: oxoglutarate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = CO2 + NADPH + succinyl-CoA." [RHEA:21400]
synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" RELATED [EC:1.2.1.52]
xref: EC:1.2.1.52
xref: KEGG_REACTION:R00265
xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21400
is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0050165
name: pantetheine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN]
synonym: "ATP:pantetheine 4'-phosphotransferase activity" RELATED [EC:2.7.1.34]
synonym: "pantetheine kinase (phosphorylating)" RELATED [EC:2.7.1.34]
xref: EC:2.7.1.34
xref: MetaCyc:PANTETHEINE-KINASE-RXN
xref: RHEA:22472
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050166
name: pantoate 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + H+ + NADH." [EC:1.1.1.106, RHEA:23000]
synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.106]
synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.106]
synonym: "panthothenase activity" RELATED [EC:1.1.1.106]
synonym: "pantoate dehydrogenase activity" RELATED [EC:1.1.1.106]
xref: EC:1.1.1.106
xref: KEGG_REACTION:R02471
xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN
xref: RHEA:23000
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050167
name: pantothenoylcysteine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2." [EC:4.1.1.30, RHEA:15077]
synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.30]
synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" RELATED [EC:4.1.1.30]
synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.30]
synonym: "pantothenylcysteine decarboxylase activity" RELATED [EC:4.1.1.30]
xref: EC:4.1.1.30
xref: KEGG_REACTION:R02972
xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN
xref: RHEA:15077
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050168
name: pentanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + pentanamide = NH4 + valerate." [EC:3.5.1.50, RHEA:10000]
synonym: "pentanamide amidohydrolase activity" RELATED [EC:3.5.1.50]
synonym: "valeramidase activity" RELATED [EC:3.5.1.50]
xref: EC:3.5.1.50
xref: KEGG_REACTION:R02938
xref: MetaCyc:PENTANAMIDASE-RXN
xref: RHEA:10000
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050169
name: obsolete peptide-tryptophan 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [PMID:4403729]
comment: This term was obsoleted because there is no enzyme known to catalyze this reaction.
is_obsolete: true

[Term]
id: GO:0050170
name: peptidyl-glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN]
synonym: "peptideglutaminase activity" RELATED [EC:3.5.1.43]
synonym: "peptidoglutaminase activity" RELATED [EC:3.5.1.43]
synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43]
synonym: "peptidyl-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.43]
xref: EC:3.5.1.43
xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN
xref: RHEA:10032
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050171
name: phenol beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "phenol b-glucosyltransferase activity" EXACT []
synonym: "phenol-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.35]
synonym: "UDP glucosyltransferase activity" RELATED [EC:2.4.1.35]
synonym: "UDP-glucose glucosyltransferase activity" RELATED [EC:2.4.1.35]
synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.35]
synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.35]
synonym: "UDPglucosyltransferase activity" RELATED [EC:2.4.1.35]
synonym: "uridine diphosphoglucosyltransferase activity" RELATED [EC:2.4.1.35]
xref: EC:2.4.1.35
xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050172
name: phenylalanine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O." [EC:1.13.12.9, RHEA:10712]
synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" RELATED [EC:1.13.12.9]
synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" RELATED [EC:1.13.12.9]
synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.9]
synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" RELATED [EC:1.13.12.9]
synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" RELATED [EC:1.13.12.9]
xref: EC:1.13.12.9
xref: KEGG_REACTION:R00690
xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN
xref: RHEA:10712
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050173
name: obsolete phenylalanine adenylyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H+." [EC:2.7.7.54]
comment: This term was obsoleted because this reaction is not believed to exist anymore.
synonym: "ATP:L-phenylalanine adenylyltransferase activity" RELATED [EC:2.7.7.54]
synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT []
synonym: "L-phenylalanine adenylyltransferase activity" RELATED [EC:2.7.7.54]
is_obsolete: true

[Term]
id: GO:0050174
name: phenylalanine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN]
synonym: "aromatic L-amino acid decarboxylase activity" BROAD []
synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT []
synonym: "L-phenylalanine carboxy-lyase activity" RELATED [EC:4.1.1.53]
synonym: "L-phenylalanine decarboxylase activity" RELATED [EC:4.1.1.53]
xref: EC:4.1.1.53
xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN
xref: RHEA:19717
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050175
name: phenylalanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN]
synonym: "L-phenylalanine dehydrogenase activity" RELATED [EC:1.4.1.20]
synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.20]
synonym: "PHD" RELATED [EC:1.4.1.20]
synonym: "PheDH activity" RELATED [EC:1.4.1.20]
xref: EC:1.4.1.20
xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN
xref: RHEA:21408
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050176
name: phenylalanine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H+." [EC:2.3.1.53, RHEA:17801]
synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" RELATED [EC:2.3.1.53]
synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" RELATED [EC:2.3.1.53]
xref: EC:2.3.1.53
xref: KEGG_REACTION:R00693
xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:17801
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0050177
name: phenylpyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN]
synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" RELATED [EC:4.1.1.43]
synonym: "phenylpyruvate carboxy-lyase activity" RELATED [EC:4.1.1.43]
xref: EC:4.1.1.43
xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN
xref: RHEA:14185
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050178
name: phenylpyruvate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [RHEA:17097]
synonym: "phenylpyruvate keto--enol tautomerase activity" EXACT [EC:5.3.2.1]
synonym: "phenylpyruvate keto-enol-isomerase activity" EXACT [EC:5.3.2.1]
synonym: "phenylpyruvic keto--enol isomerase activity" EXACT [EC:5.3.2.1]
xref: EC:5.3.2.1
xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN
xref: RHEA:17097
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0050179
name: phenylserine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine." [EC:4.1.2.26, RHEA:21712]
synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" RELATED [EC:4.1.2.26]
synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" RELATED [EC:4.1.2.26]
xref: EC:4.1.2.26
xref: KEGG_REACTION:R01766
xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN
xref: RHEA:21712
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050180
name: phloretin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phloretin = H+ + phloretate + phloroglucinol." [EC:3.7.1.4, RHEA:23396]
synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" RELATED [EC:3.7.1.4]
synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4]
xref: EC:3.7.1.4
xref: KEGG_REACTION:R02901
xref: MetaCyc:PHLORETIN-HYDROLASE-RXN
xref: RHEA:23396
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0050181
name: phorbol-diester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phorbol 12,13-dibutanoate = butanoate + H+ + phorbol 13-butanoate." [EC:3.1.1.51, RHEA:21316]
synonym: "12,13-diacylphorbate 12-acylhydrolase activity" RELATED [EC:3.1.1.51]
synonym: "diacylphorbate 12-hydrolase activity" RELATED [EC:3.1.1.51]
synonym: "PDEH" RELATED [EC:3.1.1.51]
synonym: "phorbol-12,13-diester 12-ester hydrolase activity" RELATED [EC:3.1.1.51]
xref: EC:3.1.1.51
xref: KEGG_REACTION:R04119
xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN
xref: RHEA:21316
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050182
name: phosphate butyryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA." [EC:2.3.1.19, RHEA:20892]
synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" RELATED [EC:2.3.1.19]
synonym: "phosphotransbutyrylase activity" RELATED [EC:2.3.1.19]
xref: EC:2.3.1.19
xref: KEGG_REACTION:R01174
xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN
xref: RHEA:20892
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050183
name: phosphatidylcholine 12-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O." [RHEA:46360]
synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" RELATED [EC:1.14.18.4]
synonym: "oleate D12-hydroxylase activity" EXACT []
synonym: "oleate Delta(12)-hydroxylase activity" RELATED [EC:1.14.18.4]
synonym: "oleate delta12-hydroxylase activity" RELATED [EC:1.14.18.4]
synonym: "oleate delta12-monooxygenase activity" RELATED [EC:1.14.18.4]
synonym: "ricinoleic acid synthase activity" RELATED [EC:1.14.18.4]
xref: EC:1.14.18.4
xref: KEGG_REACTION:R03476
xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN
xref: RHEA:46360
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050184
name: acyl-lipid omega-6 desaturase (cytochrome b5) activity
namespace: molecular_function
alt_id: GO:0102855
alt_id: GO:0102857
alt_id: GO:0102860
alt_id: GO:0102861
alt_id: GO:0102871
def: "Catalysis of the reaction: a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O." [RHEA:46332]
synonym: "1-16:0-2-18:1-phosphatidylcholine desaturase activity" NARROW []
synonym: "1-18:1-2-18:2-phosphatidylcholine desaturase activity" NARROW []
synonym: "1-18:1-2-18:2-phosphatidylcholine synthase activity" NARROW []
synonym: "1-18:1-2-18:3-phosphatidylcholinedesaturase activity" NARROW []
synonym: "1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming)" NARROW []
synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" RELATED []
synonym: "linoleate synthase activity" RELATED [EC:1.14.19.22]
synonym: "oleate desaturase activity" RELATED [EC:1.14.19.22]
synonym: "oleoyl-CoA desaturase activity" RELATED [EC:1.14.19.22]
synonym: "oleoylphosphatidylcholine desaturase activity" RELATED []
synonym: "phosphatidylcholine desaturase activity" RELATED [EC:1.14.19.22]
xref: EC:1.14.19.22
xref: KEGG_REACTION:R03475
xref: MetaCyc:RXN-9669
xref: RHEA:46332
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0050185
name: phosphatidylinositol deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+." [EC:3.1.1.52, RHEA:18001]
synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" RELATED [EC:3.1.1.52]
synonym: "phosphatidylinositol phospholipase A2 activity" RELATED [EC:3.1.1.52]
xref: EC:3.1.1.52
xref: KEGG_REACTION:R03360
xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN
xref: RHEA:18001
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050186
name: phosphoadenylylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate." [EC:3.6.2.2]
synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" RELATED [EC:3.6.2.2]
synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" RELATED [EC:3.6.2.2]
synonym: "3-phosphoadenylyl sulfatase activity" RELATED [EC:3.6.2.2]
synonym: "PAPS sulfatase activity" RELATED [EC:3.6.2.2]
synonym: "phosphoadenylylsulphatase activity" EXACT []
xref: EC:3.6.2.2
xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN
xref: RHEA:11232
is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides

[Term]
id: GO:0050187
name: phosphoamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate." [RHEA:12977]
synonym: "creatine phosphatase activity" RELATED [EC:3.9.1.1]
synonym: "phosphamide hydrolase activity" RELATED [EC:3.9.1.1]
xref: EC:3.9.1.1
xref: KEGG_REACTION:R01882
xref: MetaCyc:PHOSPHOAMIDASE-RXN
xref: RHEA:12977
is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds

[Term]
id: GO:0050188
name: phosphoenolpyruvate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, RHEA:17013]
synonym: "PEP mutase activity" RELATED [EC:5.4.2.9]
synonym: "PEP phosphomutase activity" RELATED [EC:5.4.2.9]
synonym: "PEPPM" RELATED [EC:5.4.2.9]
synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" RELATED [EC:5.4.2.9]
synonym: "phosphoenolpyruvate phosphomutase activity" RELATED [EC:5.4.2.9]
synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" RELATED [EC:5.4.2.9]
xref: EC:5.4.2.9
xref: KEGG_REACTION:R00661
xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN
xref: RHEA:17013
is_a: GO:0016868 ! intramolecular phosphotransferase activity

[Term]
id: GO:0050189
name: phosphoenolpyruvate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phosphoenolpyruvate = phosphate + pyruvate." [EC:3.1.3.60, RHEA:19997]
synonym: "PEP phosphatase activity" RELATED [EC:3.1.3.60]
synonym: "phosphoenolpyruvate phosphohydrolase activity" RELATED [EC:3.1.3.60]
xref: EC:3.1.3.60
xref: KEGG_REACTION:R00208
xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN
xref: RHEA:19997
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050190
name: phosphoglucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H+." [EC:2.7.1.10, RHEA:13377]
synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.10]
synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.10]
synonym: "glucose-phosphate kinase activity" RELATED [EC:2.7.1.10]
synonym: "phosphoglucokinase (phosphorylating)" RELATED [EC:2.7.1.10]
xref: EC:2.7.1.10
xref: KEGG_REACTION:R00949
xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN
xref: RHEA:13377
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050191
name: phosphoglycerate kinase (GTP) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H+." [EC:2.7.2.10, RHEA:23332]
synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" RELATED [EC:2.7.2.10]
xref: EC:2.7.2.10
xref: KEGG_REACTION:R01517
xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN
xref: RHEA:23332
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0050192
name: phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate." [EC:3.1.3.20, RHEA:21156]
synonym: "D-2-phosphoglycerate phosphatase activity" RELATED [EC:3.1.3.20]
synonym: "D-glycerate-2-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.20]
synonym: "glycerophosphate phosphatase activity" RELATED [EC:3.1.3.20]
xref: EC:3.1.3.20
xref: KEGG_REACTION:R01748
xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN
xref: RHEA:21156
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050193
name: phosphoketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN]
synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" RELATED [EC:4.1.2.9]
synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" RELATED [EC:4.1.2.9]
synonym: "xylulose-5-phosphate phosphoketolase activity" RELATED [EC:4.1.2.9]
xref: EC:4.1.2.9
xref: MetaCyc:PHOSPHOKETOLASE-RXN
xref: RHEA:10468
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050194
name: phosphonoacetaldehyde hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate." [RHEA:18905]
synonym: "2-oxoethylphosphonate phosphonohydrolase activity" RELATED [EC:3.11.1.1]
synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" RELATED [EC:3.11.1.1]
synonym: "phosphonatase activity" RELATED [EC:3.11.1.1]
synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" RELATED [EC:3.11.1.1]
xref: EC:3.11.1.1
xref: KEGG_REACTION:R00747
xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN
xref: RHEA:18905
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0050195
name: phosphoribokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H+." [EC:2.7.1.18, RHEA:21216]
synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.18]
synonym: "phosphoribokinase (phosphorylating)" RELATED [EC:2.7.1.18]
xref: EC:2.7.1.18
xref: KEGG_REACTION:R01050
xref: MetaCyc:PHOSPHORIBOKINASE-RXN
xref: RHEA:21216
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050196
name: [phosphorylase] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN]
synonym: "glycogen phosphorylase phosphatase activity" RELATED [EC:3.1.3.17]
synonym: "phosphorylase a phosphatase activity" RELATED [EC:3.1.3.17]
synonym: "phosphorylase a phosphohydrolase activity" RELATED [EC:3.1.3.17]
synonym: "phosphorylase phosphatase activity" EXACT []
synonym: "PR-enzyme" RELATED [EC:3.1.3.17]
synonym: "protein phosphatase C" RELATED [EC:3.1.3.17]
synonym: "type 1 protein phosphatase activity" RELATED [EC:3.1.3.17]
xref: EC:3.1.3.17
xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0050197
name: phytanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA." [EC:6.2.1.24, RHEA:21380]
synonym: "phytanate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.24]
synonym: "phytanoyl-CoA ligase activity" RELATED [EC:6.2.1.24]
xref: EC:6.2.1.24
xref: KEGG_REACTION:R03631
xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN
xref: Reactome:R-HSA-389622 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate"
xref: RHEA:21380
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050198
name: pinosylvin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H+ + 3 malonyl-CoA = 4 CO2 + 4 CoA + pinosylvin." [EC:2.3.1.146, RHEA:12552]
synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" RELATED [EC:2.3.1.146]
synonym: "pine stilbene synthase activity" RELATED [EC:2.3.1.146]
synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146]
xref: EC:2.3.1.146
xref: KEGG_REACTION:R02505
xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN
xref: RHEA:12552
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050199
name: piperidine N-piperoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H+." [EC:2.3.1.145, RHEA:14561]
synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" RELATED [EC:2.3.1.145]
synonym: "piperidine piperoyltransferase activity" RELATED [EC:2.3.1.145]
synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" RELATED [EC:2.3.1.145]
xref: EC:2.3.1.145
xref: KEGG_REACTION:R03994
xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN
xref: RHEA:14561
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050200
name: obsolete plasmalogen synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [GOC:rynl]
comment: The reason for obsoletion is that this term is equivalent to GO:0047159 1-alkenylglycerophosphocholine O-acyltransferase activity.
synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" RELATED []
synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" RELATED []
synonym: "lysoplasmenylcholine acyltransferase activity" RELATED []
synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" RELATED []
is_obsolete: true
replaced_by: GO:0047159

[Term]
id: GO:0050201
name: fucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+." [EC:2.7.1.52, RHEA:13241]
synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" RELATED [EC:2.7.1.52]
synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" RELATED [EC:2.7.1.52]
synonym: "fucokinase (phosphorylating) activity" RELATED [EC:2.7.1.52]
synonym: "fucose kinase activity" RELATED [EC:2.7.1.52]
synonym: "L-fucokinase activity" RELATED [EC:2.7.1.52]
synonym: "L-fucose kinase activity" RELATED [EC:2.7.1.52]
xref: EC:2.7.1.52
xref: KEGG_REACTION:R03161
xref: MetaCyc:FUCOKINASE-RXN
xref: Reactome:R-HSA-6787540 "FUK phosphorylates beta-Fuc to Fuc1P"
xref: RHEA:13241
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050202
name: octopamine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4." [EC:4.2.1.87, RHEA:18173]
synonym: "octopamine hydro-lyase (deaminating)" RELATED [EC:4.2.1.87]
synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87]
synonym: "octopamine hydrolyase activity" RELATED [EC:4.2.1.87]
xref: EC:4.2.1.87
xref: KEGG_REACTION:R03358
xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN
xref: RHEA:18173
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050203
name: oxalate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H+ + oxalyl-CoA." [RHEA:18293]
synonym: "oxalate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.8]
synonym: "oxalyl coenzyme A synthetase activity" RELATED [EC:6.2.1.8]
synonym: "oxalyl-CoA synthetase activity" RELATED [EC:6.2.1.8]
xref: EC:6.2.1.8
xref: KEGG_REACTION:R01558
xref: MetaCyc:OXALATE--COA-LIGASE-RXN
xref: RHEA:18293
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050204
name: oxalomalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate." [EC:4.1.3.13, RHEA:22032]
synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" RELATED [EC:4.1.3.13]
synonym: "3-oxalomalate glyoxylate-lyase activity" RELATED [EC:4.1.3.13]
xref: EC:4.1.3.13
xref: KEGG_REACTION:R00477
xref: MetaCyc:OXALOMALATE-LYASE-RXN
xref: RHEA:22032
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0050205
name: oxamate carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate." [EC:2.1.3.5, RHEA:22984]
synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" RELATED [EC:2.1.3.5]
synonym: "oxamic transcarbamylase activity" RELATED [EC:2.1.3.5]
xref: EC:2.1.3.5
xref: KEGG_REACTION:R02937
xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN
xref: RHEA:22984
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050206
name: oximinotransferase activity
namespace: molecular_function
alt_id: GO:0016770
def: "Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate." [RHEA:11624]
synonym: "oximase activity" RELATED [EC:2.6.3.1]
synonym: "oximinotransaminase activity" RELATED []
synonym: "pyruvate-acetone oximinotransferase activity" RELATED [EC:2.6.3.1]
synonym: "transoximase activity" RELATED [EC:2.6.3.1]
synonym: "transoximinase activity" RELATED [EC:2.6.3.1]
xref: EC:2.6.3.1
xref: KEGG_REACTION:R03796
xref: MetaCyc:OXIMINOTRANSFERASE-RXN
xref: RHEA:11624
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0050207
name: plasmanylethanolamine desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O." [RHEA:22956]
synonym: "2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase activity" RELATED [EC:1.14.19.77]
synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" RELATED [EC:1.14.19.77]
synonym: "alkylacylglycerophosphoethanolamine desaturase activity" RELATED [EC:1.14.19.77]
synonym: "plasmenylethanolamine desaturase activity" EXACT []
xref: EC:1.14.19.77
xref: MetaCyc:RXN-17732
xref: RHEA:22956
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0050208
name: polysialic-acid O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT []
xref: EC:2.3.1.136
xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN
xref: RHEA:11604
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050209
name: polyvinyl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN]
synonym: "dehydrogenase, polyvinyl alcohol" RELATED [EC:1.1.3.30]
synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.30]
synonym: "PVA oxidase activity" RELATED [EC:1.1.3.30]
xref: EC:1.1.3.30
xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN
xref: RHEA:21688
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050210
name: prenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + H2O = diphosphate + prenol." [RHEA:21496]
synonym: "prenol pyrophosphatase activity" RELATED [EC:3.1.7.1]
synonym: "prenyl-diphosphate diphosphohydrolase activity" RELATED [EC:3.1.7.1]
synonym: "prenyl-pyrophosphatase activity" EXACT []
synonym: "prenylphosphatase activity" RELATED [EC:3.1.7.1]
xref: EC:3.1.7.1
xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN
xref: RHEA:21496
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0050211
name: procollagen galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN]
synonym: "collagen galactosyltransferase activity" RELATED [EC:2.4.1.50]
synonym: "collagen hydroxylysyl galactosyltransferase activity" RELATED [EC:2.4.1.50]
synonym: "hydroxylysine galactosyltransferase activity" RELATED [EC:2.4.1.50]
synonym: "UDP galactose-collagen galactosyltransferase activity" RELATED [EC:2.4.1.50]
synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" RELATED [EC:2.4.1.50]
synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" RELATED [EC:2.4.1.50]
synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" RELATED [EC:2.4.1.50]
synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" RELATED [EC:2.4.1.50]
xref: EC:2.4.1.50
xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-1981120 "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2"
xref: Reactome:R-HSA-1981128 "Galactosylation of collagen propeptide hydroxylysines by PLOD3"
xref: RHEA:12637
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0050212
name: progesterone 11-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O." [RHEA:18205]
synonym: "progesterone 11-alpha-hydroxylase activity" RELATED [EC:1.14.99.14]
synonym: "progesterone 11a-monooxygenase activity" EXACT []
synonym: "progesterone 11alpha-hydroxylase activity" RELATED [EC:1.14.99.14]
synonym: "progesterone 11alpha-monooxygenase activity" RELATED [EC:1.14.99.14]
synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" RELATED [EC:1.14.99.14]
xref: EC:1.14.99.14
xref: KEGG_REACTION:R02214
xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN
xref: RHEA:18205
is_a: GO:0050214 ! progesterone monooxygenase activity

[Term]
id: GO:0050213
name: obsolete progesterone 5-alpha-reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [GOC:curators]
comment: The reason for obsoletion is that it is more specific than the specificity of any known gene product.
synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" RELATED [EC:1.3.1.30]
synonym: "delta4-steroid 5alpha-reductase (progesterone)" RELATED [EC:1.3.1.30]
synonym: "progesterone 5a-reductase activity" EXACT []
synonym: "progesterone 5alpha-reductase activity" RELATED [EC:1.3.1.30]
synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30]
is_obsolete: true
replaced_by: GO:0047751

[Term]
id: GO:0050214
name: progesterone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + O2 + progesterone = A + H2O + testosterone acetate." [RHEA:11984]
synonym: "progesterone hydroxylase activity" RELATED [EC:1.14.99.4]
synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.99.4]
xref: EC:1.14.99.4
xref: KEGG_REACTION:R02212
xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN
xref: RHEA:11984
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050215
name: propanediol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,2-diol = H2O + propanal." [EC:4.2.1.28, RHEA:14569]
synonym: "1,2-propanediol dehydratase activity" RELATED [EC:4.2.1.28]
synonym: "adenosylcobalamin-dependent diol dehydratase activity" RELATED [EC:4.2.1.28]
synonym: "coenzyme B12-dependent diol dehydrase activity" RELATED [EC:4.2.1.28]
synonym: "diol dehydrase activity" RELATED [EC:4.2.1.28]
synonym: "diol dehydratase activity" RELATED [EC:4.2.1.28]
synonym: "dioldehydratase activity" RELATED [EC:4.2.1.28]
synonym: "DL-1,2-propanediol hydro-lyase activity" RELATED [EC:4.2.1.28]
synonym: "meso-2,3-butanediol dehydrase activity" RELATED [EC:4.2.1.28]
synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" RELATED [EC:4.2.1.28]
synonym: "propane-1,2-diol hydro-lyase activity" RELATED [EC:4.2.1.28]
synonym: "propanediol dehydrase activity" RELATED [EC:4.2.1.28]
xref: EC:4.2.1.28
xref: KEGG_REACTION:R02376
xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN
xref: RHEA:14569
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050216
name: propanediol-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH." [EC:1.1.1.7, RHEA:21584]
xref: EC:1.1.1.7
xref: KEGG_REACTION:R04236
xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN
xref: RHEA:21584
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050217
name: propioin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal." [EC:4.1.2.35, RHEA:11100]
synonym: "4-hydroxy-3-hexanone aldolase activity" RELATED [EC:4.1.2.35]
synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" RELATED [EC:4.1.2.35]
synonym: "4-hydroxy-3-hexanone propanal-lyase activity" RELATED [EC:4.1.2.35]
xref: EC:4.1.2.35
xref: KEGG_REACTION:R00038
xref: MetaCyc:PROPIOIN-SYNTHASE-RXN
xref: RHEA:11100
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050218
name: propionate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN]
synonym: "propanoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.17]
synonym: "propionyl-CoA synthetase activity" RELATED [EC:6.2.1.17]
xref: EC:6.2.1.17
xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN
xref: RHEA:20373
is_a: GO:0031955 ! short-chain fatty acid-CoA ligase activity

[Term]
id: GO:0050219
name: prostaglandin-A1 delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin A1 = prostaglandin C1." [RHEA:10460]
synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" RELATED [EC:5.3.3.9]
synonym: "prostaglandin A isomerase activity" RELATED [EC:5.3.3.9]
synonym: "prostaglandin-A1 D-isomerase activity" EXACT []
xref: EC:5.3.3.9
xref: KEGG_REACTION:R04565
xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN
xref: RHEA:10460
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050220
name: prostaglandin-E synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12893]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" RELATED [EC:5.3.99.3]
synonym: "endoperoxide isomerase activity" RELATED [EC:5.3.99.3]
synonym: "PGE isomerase activity" RELATED [EC:5.3.99.3]
synonym: "PGE2 isomerase activity" RELATED [EC:5.3.99.3]
synonym: "PGH-PGE isomerase activity" RELATED [EC:5.3.99.3]
synonym: "prostaglandin endoperoxide E isomerase activity" RELATED [EC:5.3.99.3]
synonym: "prostaglandin endoperoxide E2 isomerase activity" RELATED [EC:5.3.99.3]
synonym: "prostaglandin H-E isomerase activity" RELATED [EC:5.3.99.3]
synonym: "prostaglandin R-prostaglandin E isomerase activity" RELATED [EC:5.3.99.3]
synonym: "Prostaglandin-H(2) E-isomerase activity" RELATED [EC:5.3.99.3]
synonym: "prostaglandin-H2 E-isomerase activity" RELATED [EC:5.3.99.3]
xref: EC:5.3.99.3
xref: KEGG_REACTION:R02265
xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN
xref: Reactome:R-HSA-2161660 "PGH2 is isomerised to PGE2 by PTGES"
xref: Reactome:R-HSA-265295 "Prostaglandin E synthase isomerizes PGH2 to PGE2"
xref: RHEA:12893
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0050221
name: prostaglandin E2 9-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" RELATED [EC:1.1.1.189]
synonym: "9-keto-prostaglandin E(2) reductase activity" RELATED [EC:1.1.1.189]
synonym: "9-keto-prostaglandin E2 reductase activity" RELATED [EC:1.1.1.189]
synonym: "9-ketoprostaglandin reductase activity" RELATED [EC:1.1.1.189]
synonym: "PGE(2) 9-ketoreductase activity" RELATED [EC:1.1.1.189]
synonym: "PGE(2) 9-oxoreductase activity" RELATED [EC:1.1.1.189]
synonym: "PGE-9-ketoreductase activity" RELATED [EC:1.1.1.189]
synonym: "PGE2 9-ketoreductase activity" RELATED [EC:1.1.1.189]
synonym: "PGE2 9-oxoreductase activity" RELATED [EC:1.1.1.189]
synonym: "PGE2-9-ketoreductase activity" RELATED [EC:1.1.1.189]
synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189]
synonym: "prostaglandin E 9-ketoreductase activity" RELATED [EC:1.1.1.189]
synonym: "prostaglandin E2-9-oxoreductase activity" RELATED [EC:1.1.1.189]
synonym: "prostaglandin-E(2) 9-oxoreductase activity" RELATED [EC:1.1.1.189]
synonym: "prostaglandin-E2 9-oxoreductase activity" RELATED [EC:1.1.1.189]
synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" RELATED [EC:1.1.1.189]
xref: EC:1.1.1.189
xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN
xref: Reactome:R-HSA-2161651 "PGE2 is converted to PGF2a by CBR1"
xref: RHEA:24508
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050223
name: protocatechuate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2." [EC:4.1.1.63, RHEA:22416]
synonym: "3,4-dihydrobenzoate decarboxylase activity" RELATED [EC:4.1.1.63]
synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" RELATED [EC:4.1.1.63]
synonym: "3,4-dihydroxybenzoate decarboxylase activity" RELATED [EC:4.1.1.63]
synonym: "protocatechuate carboxy-lyase activity" RELATED [EC:4.1.1.63]
xref: EC:4.1.1.63
xref: KEGG_REACTION:R00822
xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN
xref: RHEA:22416
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050224
name: prunasin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile." [EC:3.2.1.118, RHEA:16489]
synonym: "prunasin b-glucosidase activity" EXACT []
synonym: "prunasin beta-D-glucohydrolase activity" RELATED [EC:3.2.1.118]
synonym: "prunasin hydrolase activity" RELATED [EC:3.2.1.118]
xref: EC:3.2.1.118
xref: KEGG_REACTION:R02558
xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:16489
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050225
name: pseudouridine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H+ + pseudouridine 5'-phosphate." [EC:2.7.1.83, RHEA:22448]
synonym: "ATP:pseudouridine 5'-phosphotransferase activity" RELATED [EC:2.7.1.83]
synonym: "pseudouridine kinase (phosphorylating)" RELATED [EC:2.7.1.83]
xref: EC:2.7.1.83
xref: KEGG_REACTION:R03315
xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN
xref: RHEA:22448
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050226
name: psychosine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" RELATED [EC:2.8.2.13]
synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" RELATED [EC:2.8.2.13]
synonym: "PAPS:psychosine sulphotransferase activity" RELATED [EC:2.8.2.13]
synonym: "psychosine sulphotransferase activity" EXACT []
xref: EC:2.8.2.13
xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN
xref: RHEA:14137
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050227
name: pteridine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN]
synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" RELATED [EC:1.17.3.1]
xref: EC:1.17.3.1
xref: MetaCyc:PTERIDINE-OXIDASE-RXN
xref: RHEA:12777
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0050228
name: pterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN]
synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" RELATED [EC:3.5.4.11]
synonym: "acrasinase activity" RELATED [EC:3.5.4.11]
xref: EC:3.5.4.11
xref: MetaCyc:PTERIN-DEAMINASE-RXN
xref: RHEA:11904
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050229
name: obsolete pterocarpin synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN]
comment: The reaction has been deleted as it is the result of the activity of two\n separate enzymes: vestitone reductase (EC 1.1.1.348 and medicarpin synthase\nEC 4.2.1.139.
synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.1.1.246]
synonym: "pterocarpan synthase activity" RELATED [EC:1.1.1.246]
is_obsolete: true
consider: GO:0140859
consider: GO:0140860

[Term]
id: GO:0050230
name: purine imidazole-ring cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" RELATED [EC:4.3.2.4]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" RELATED [EC:4.3.2.4]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" RELATED [EC:4.3.2.4]
xref: EC:4.3.2.4
xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0050231
name: putrescine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H+ + phosphate." [EC:2.1.3.6, RHEA:21936]
synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" RELATED [EC:2.1.3.6]
synonym: "PTCase activity" RELATED [EC:2.1.3.6]
synonym: "putrescine synthase activity" RELATED [EC:2.1.3.6]
synonym: "putrescine transcarbamylase activity" RELATED [EC:2.1.3.6]
xref: EC:2.1.3.6
xref: KEGG_REACTION:R01399
xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN
xref: RHEA:21936
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050232
name: putrescine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4+." [RHEA:18273]
synonym: "putrescine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.10]
xref: EC:1.4.3.10
xref: MetaCyc:PUTRESCINE-OXIDASE-RXN
xref: RHEA:18273
is_a: GO:0052597 ! diamine oxidase activity

[Term]
id: GO:0050233
name: pyranose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2." [EC:1.1.3.10, RHEA:10552]
synonym: "glucose 2-oxidase activity" RELATED [EC:1.1.3.10]
synonym: "pyranose-2-oxidase activity" RELATED [EC:1.1.3.10]
synonym: "pyranose:oxygen 2-oxidoreductase activity" RELATED [EC:1.1.3.10]
xref: EC:1.1.3.10
xref: KEGG_REACTION:R00302
xref: MetaCyc:PYRANOSE-OXIDASE-RXN
xref: RHEA:10552
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050234
name: pyrazolylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O." [EC:4.2.1.50, RHEA:24512]
synonym: "beta-pyrazolylalaninase activity" RELATED [EC:4.2.1.50]
synonym: "L-serine hydro-lyase (adding pyrazole)" RELATED [EC:4.2.1.50]
synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50]
xref: EC:4.2.1.50
xref: KEGG_REACTION:R02378
xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN
xref: RHEA:24512
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050235
name: pyridoxal 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + pyridoxal = 4-pyridoxolactone + H+ + NADH." [EC:1.1.1.107, RHEA:21336]
synonym: "pyridoxal dehydrogenase activity" RELATED [EC:1.1.1.107]
synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.107]
xref: EC:1.1.1.107
xref: KEGG_REACTION:R01707
xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN
xref: RHEA:21336
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050236
name: pyridoxine:NADP 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + pyridoxine = H+ + NADPH + pyridoxal." [EC:1.1.1.65, RHEA:16129]
synonym: "PL reductase activity" RELATED [EC:1.1.1.65]
synonym: "pyridoxal reductase activity" RELATED [EC:1.1.1.65]
synonym: "pyridoxin dehydrogenase activity" RELATED [EC:1.1.1.65]
synonym: "pyridoxine dehydrogenase activity" RELATED [EC:1.1.1.65]
synonym: "pyridoxine:NADP 4-oxidoreductase activity" RELATED [EC:1.1.1.65]
synonym: "pyridoxol dehydrogenase activity" RELATED [EC:1.1.1.65]
xref: EC:1.1.1.65
xref: KEGG_REACTION:R01708
xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN
xref: RHEA:16129
is_a: GO:0004033 ! aldo-keto reductase (NADPH) activity

[Term]
id: GO:0050237
name: pyridoxine 4-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN]
synonym: "pyridoxin 4-oxidase activity" RELATED [EC:1.1.3.12]
synonym: "pyridoxine:oxygen 4-oxidoreductase activity" RELATED [EC:1.1.3.12]
synonym: "pyridoxol 4-oxidase activity" RELATED [EC:1.1.3.12]
xref: EC:1.1.3.12
xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN
xref: RHEA:15033
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050238
name: pyridoxine 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN]
synonym: "pyridoxal-5-dehydrogenase activity" RELATED [EC:1.1.99.9]
synonym: "pyridoxin 5-dehydrogenase activity" RELATED [EC:1.1.99.9]
synonym: "pyridoxine 5'-dehydrogenase activity" RELATED [EC:1.1.99.9]
synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" RELATED [EC:1.1.99.9]
synonym: "pyridoxine:acceptor 5-oxidoreductase activity" RELATED [EC:1.1.99.9]
synonym: "pyridoxol 5-dehydrogenase activity" RELATED [EC:1.1.99.9]
xref: EC:1.1.99.9
xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN
xref: RHEA:14497
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050239
name: pyrithiamine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN]
synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" RELATED [EC:3.5.4.20]
xref: EC:3.5.4.20
xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN
xref: RHEA:14537
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050240
name: pyrogallol 1,2-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H+." [EC:1.13.11.35, RHEA:19673]
synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.35]
synonym: "pyrogallol 1,2-dioxygenase activity" RELATED [EC:1.13.11.35]
xref: EC:1.13.11.35
xref: KEGG_REACTION:R03246
xref: MetaCyc:PYROGALLOL-12-OXYGENASE-RXN
xref: RHEA:19673
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050241
name: pyrroline-2-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN]
synonym: "delta1-pyrroline-2-carboxylate reductase activity" RELATED [EC:1.5.1.1]
synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.5.1.1]
xref: EC:1.5.1.1
xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050242
name: pyruvate, phosphate dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H+ + phosphoenolpyruvate." [RHEA:10756]
synonym: "ATP:pyruvate, phosphate phosphotransferase activity" RELATED [EC:2.7.9.1]
synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1]
synonym: "PPDK" RELATED [EC:2.7.9.1]
synonym: "pyruvate, Pi dikinase activity" RELATED [EC:2.7.9.1]
synonym: "pyruvate,orthophosphate dikinase activity" RELATED [EC:2.7.9.1]
synonym: "pyruvate,phosphate dikinase activity" RELATED [EC:2.7.9.1]
synonym: "pyruvate-inorganic phosphate dikinase activity" RELATED [EC:2.7.9.1]
synonym: "pyruvate-phosphate dikinase (phosphorylating)" RELATED [EC:2.7.9.1]
synonym: "pyruvate-phosphate dikinase activity" RELATED [EC:2.7.9.1]
synonym: "pyruvate-phosphate ligase activity" RELATED [EC:2.7.9.1]
synonym: "pyruvic-phosphate dikinase activity" RELATED [EC:2.7.9.1]
synonym: "pyruvic-phosphate ligase activity" RELATED [EC:2.7.9.1]
xref: EC:2.7.9.1
xref: KEGG_REACTION:R00206
xref: MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN
xref: RHEA:10756
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0050243
name: pyruvate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + NADP+ + pyruvate = acetyl-CoA + CO2 + NADPH." [RHEA:17425]
synonym: "pyruvate:NADP(+) oxidoreductase activity" RELATED [EC:1.2.1.51]
synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.1.51]
synonym: "pyruvate:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.51]
xref: EC:1.2.1.51
xref: KEGG_REACTION:R00210
xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:17425
is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0050244
name: pyruvate oxidase (CoA-acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + H+ + O2 + pyruvate = acetyl-CoA + CO2 + H2O2." [RHEA:21912]
synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.3.6]
xref: EC:1.2.3.6
xref: KEGG_REACTION:R00211
xref: MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN
xref: RHEA:21912
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050245
name: obsolete quercitrinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin." [GOC:curators]
comment: This term was obsoleted because the EC number to which it was associated was transferred to EC:3.2.1.40, which corresponds to alpha-L-rhamnosidase activity ; GO:0030596.
is_obsolete: true
replaced_by: GO:0030596

[Term]
id: GO:0050246
name: questin monooxygenase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + questin = demethylsulochrin + NADP+." [RHEA:10836]
synonym: "questin oxygenase activity" RELATED [EC:1.14.13.43]
synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" RELATED [EC:1.14.13.43]
xref: EC:1.14.13.43
xref: KEGG_REACTION:R02417
xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN
xref: RHEA:10836
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050247
name: raucaffricine beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, RHEA:14557]
synonym: "raucaffricine b-glucosidase activity" EXACT []
synonym: "raucaffricine beta-D-glucohydrolase activity" RELATED [EC:3.2.1.125]
synonym: "raucaffricine beta-D-glucosidase activity" RELATED [EC:3.2.1.125]
synonym: "raucaffricine glucosidase activity" RELATED [EC:3.2.1.125]
xref: EC:3.2.1.125
xref: KEGG_REACTION:R03703
xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN
xref: RHEA:14557
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050248
name: Renilla-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "aequorin activity" NARROW [EC:1.13.12.5]
synonym: "luciferase (Renilla luciferin)" RELATED [EC:1.13.12.5]
synonym: "luciferase activity" BROAD [EC:1.13.12.5]
synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.5]
synonym: "Renilla-type luciferase activity" RELATED [EC:1.13.12.5]
xref: EC:1.13.12.5
xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: RHEA:14765
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0050249
name: Renilla-luciferin sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H+ + luciferyl sulfate." [EC:2.8.2.10, RHEA:20481]
synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" RELATED [EC:2.8.2.10]
synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" RELATED [EC:2.8.2.10]
synonym: "luciferin sulfokinase activity" RELATED [EC:2.8.2.10]
synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10]
synonym: "Renilla-luciferin sulphotransferase activity" EXACT []
xref: EC:2.8.2.10
xref: KEGG_REACTION:R03138
xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN
xref: RHEA:20481
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050251
name: retinol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [GOC:pde, RHEA:19141]
synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT []
synonym: "all-trans-retinol isomerase activity" EXACT []
xref: KEGG_REACTION:R02369
xref: Reactome:R-HSA-2465926 "An atROL isomerase isomerises atROL to 11cROL"
xref: RHEA:19141
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050252
name: retinol O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:retinol O-acyltransferase activity" RELATED [EC:2.3.1.76]
synonym: "retinol acyltransferase activity" RELATED [EC:2.3.1.76]
synonym: "retinol fatty-acyltransferase activity" RELATED [EC:2.3.1.76]
xref: EC:2.3.1.76
xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN
xref: Reactome:R-HSA-2465919 "AWAT2 transfers PALM to 11cROL forming 11cRPALM"
xref: Reactome:R-HSA-8848585 "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM"
xref: RHEA:11488
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0050253
name: retinyl-palmitate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+." [RHEA:21508]
synonym: "retinyl ester hydrolase activity" RELATED []
synonym: "retinyl palmitate hydrolase activity" RELATED []
synonym: "retinyl palmitate hydrolyase activity" RELATED []
synonym: "retinyl-palmitate palmitohydrolase activity" RELATED []
xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN
xref: Reactome:R-HSA-2404133 "A REH hydrolses atREs to atROL and FAs"
xref: Reactome:R-HSA-8848355 "PNPLA4 hydrolyzes retinyl palmitate"
xref: Reactome:R-HSA-975593 "PNLIP:CLPS hydrolyses RPALM to atROL and PALM"
xref: Reactome:R-HSA-975594 "PLB1 hydrolyses RPALM to atROL"
xref: RHEA:21508
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050254
name: rhodopsin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [PMID:14654303]
synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14]
synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14]
synonym: "opsin kinase (phosphorylating) activity" RELATED [EC:2.7.11.14]
synonym: "opsin kinase activity" RELATED [EC:2.7.11.14]
synonym: "rhodopsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14]
xref: EC:2.7.11.14
xref: MetaCyc:2.7.11.14-RXN
xref: Reactome:R-HSA-2581474 "GRK1,4,7 phosphorylate MII to p-MII"
xref: RHEA:23356
is_a: GO:0004703 ! G protein-coupled receptor kinase activity

[Term]
id: GO:0050255
name: ribitol 2-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH." [EC:1.1.1.56, RHEA:20053]
synonym: "adonitol dehydrogenase activity" RELATED [EC:1.1.1.56]
synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56]
synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56]
synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56]
synonym: "ribitol:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.56]
xref: EC:1.1.1.56
xref: KEGG_REACTION:R01895
xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN
xref: RHEA:20053
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050256
name: ribitol-5-phosphate 2-dehydrogenase [(NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137]
synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.137]
synonym: "dehydrogenase, ribitol 5-phosphate" RELATED [EC:1.1.1.137]
xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050257
name: riboflavin phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, RHEA:20409]
synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" RELATED [EC:2.7.1.42]
synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" RELATED [EC:2.7.1.42]
synonym: "G-1-P phosphotransferase activity" RELATED [EC:2.7.1.42]
synonym: "riboflavine phosphotransferase activity" RELATED [EC:2.7.1.42]
xref: EC:2.7.1.42
xref: KEGG_REACTION:R00550
xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN
xref: RHEA:20409
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050258
name: riboflavinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + H+ + riboflavin = D-ribitol + lumichrome." [EC:3.5.99.1, RHEA:11408]
synonym: "riboflavin hydrolase activity" RELATED [EC:3.5.99.1]
xref: EC:3.5.99.1
xref: KEGG_REACTION:R01732
xref: MetaCyc:RIBOFLAVINASE-RXN
xref: RHEA:11408
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050259
name: ribose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NADP+ + ribofuranose = D-ribonate + 2 H+ + NADPH." [EC:1.1.1.115, RHEA:11676]
synonym: "D-ribose dehydrogenase (NADP+)" RELATED [EC:1.1.1.115]
synonym: "D-ribose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.115]
synonym: "NADP-pentose-dehydrogenase activity" RELATED [EC:1.1.1.115]
xref: EC:1.1.1.115
xref: KEGG_REACTION:R01079
xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:11676
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050260
name: ribose-5-phosphate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH4 = 5-phospho-D-ribosylamine + ADP + 2 H+ + phosphate." [EC:6.3.4.7, RHEA:13777]
synonym: "5-phosphoribosylamine synthetase activity" RELATED [EC:6.3.4.7]
synonym: "ammonia-ribose 5-phosphate aminotransferase activity" RELATED [EC:6.3.4.7]
synonym: "ribose 5-phosphate aminotransferase activity" RELATED [EC:6.3.4.7]
synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" RELATED [EC:6.3.4.7]
xref: EC:6.3.4.7
xref: KEGG_REACTION:R01053
xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN
xref: RHEA:13777
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0050261
name: ribose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldehydo-D-ribose = D-ribulose." [RHEA:20796]
synonym: "D-ribose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.20]
synonym: "D-ribose isomerase activity" RELATED [EC:5.3.1.20]
synonym: "D-ribose ketol-isomerase activity" RELATED [EC:5.3.1.20]
xref: EC:5.3.1.20
xref: KEGG_REACTION:R01081
xref: MetaCyc:RIBOSE-ISOMERASE-RXN
xref: RHEA:20796
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050262
name: ribosylnicotinamide kinase activity
namespace: molecular_function
alt_id: GO:0000816
def: "Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide." [EC:2.7.1.22, PMID:17914902, RHEA:14017]
synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" RELATED [EC:2.7.1.22]
synonym: "nicotinamide riboside kinase activity" EXACT [PMID:15137942]
synonym: "ribosylnicotinamide kinase (phosphorylating)" RELATED [EC:2.7.1.22]
xref: EC:2.7.1.22
xref: KEGG_REACTION:R02324
xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN
xref: Reactome:R-HSA-8869627 "NMRK2 phosphorylates NR to yield NMN"
xref: Reactome:R-HSA-8869633 "NMRK1 phosphorylates NR to yield NMN"
xref: RHEA:14017
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050263
name: ribosylpyrimidine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN]
synonym: "N-ribosylpyrimidine nucleosidase activity" RELATED [EC:3.2.2.8]
synonym: "N-ribosylpyrimidine ribohydrolase activity" RELATED [EC:3.2.2.8]
synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8]
synonym: "pyrimidine nucleosidase activity" RELATED [EC:3.2.2.8]
synonym: "pyrimidine-nucleoside ribohydrolase activity" RELATED [EC:3.2.2.8]
synonym: "RihB" RELATED [EC:3.2.2.8]
synonym: "YeiK" RELATED [EC:3.2.2.8]
xref: EC:3.2.2.8
xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN
xref: RHEA:56816
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0050264
name: rifamycin-B oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + O2 + rifamycin B = H2O2 + rifamycin O." [EC:1.10.3.6, RHEA:11292]
synonym: "rifamycin B oxidase activity" RELATED [EC:1.10.3.6]
synonym: "rifamycin-B-oxidase activity" EXACT []
synonym: "rifamycin-B:oxygen oxidoreductase activity" RELATED [EC:1.10.3.6]
xref: EC:1.10.3.6
xref: KEGG_REACTION:R03736
xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN
xref: RHEA:11292
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0050265
name: RNA uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN]
synonym: "poly(U) polymerase activity" EXACT [GOC:dph, GOC:mah]
synonym: "polynucleotide uridylyltransferase activity" EXACT [GOC:dph, GOC:mah]
synonym: "terminal uridylyltransferase activity" RELATED [EC:2.7.7.52]
synonym: "TUT activity" RELATED [EC:2.7.7.52]
synonym: "UTP:RNA uridylyltransferase activity" EXACT []
xref: EC:2.7.7.52
xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN
xref: Reactome:R-HSA-8941312 "TUT4,TUT7 oligouridylate mRNA"
xref: RHEA:14785
is_a: GO:0070569 ! uridylyltransferase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0050266
name: rosmarinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140]
synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" RELATED [EC:2.3.1.140]
synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" RELATED [EC:2.3.1.140]
synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" RELATED [EC:2.3.1.140]
synonym: "rosmarinic acid synthase activity" RELATED [EC:2.3.1.140]
xref: EC:2.3.1.140
xref: MetaCyc:RXN-7633
xref: RHEA:22344
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050267
name: rubber cis-polyprenylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate." [RHEA:18801]
synonym: "cis-prenyl transferase activity" RELATED [EC:2.5.1.20]
synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" RELATED [EC:2.5.1.20]
synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" RELATED [EC:2.5.1.20]
synonym: "rubber allyltransferase activity" RELATED [EC:2.5.1.20]
synonym: "rubber polymerase activity" RELATED [EC:2.5.1.20]
synonym: "rubber prenyltransferase activity" RELATED [EC:2.5.1.20]
synonym: "rubber transferase activity" BROAD [EC:2.5.1.20]
xref: EC:2.5.1.20
xref: MetaCyc:2.5.1.20-RXN
xref: RHEA:18801
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0050268
name: coniferyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [RHEA:22444]
synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.194]
xref: EC:1.1.1.194
xref: MetaCyc:RXN-2602
xref: RHEA:22444
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050269
name: coniferyl-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68]
synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.68]
xref: EC:1.2.1.68
xref: MetaCyc:RXN-1241
is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0050270
name: S-adenosylhomocysteine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O + H+ = S-inosyl-L-homocysteine + NH4." [EC:3.5.4.28, RHEA:20716]
synonym: "adenosylhomocysteine deaminase activity" RELATED [EC:3.5.4.28]
synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" RELATED [EC:3.5.4.28]
xref: EC:3.5.4.28
xref: KEGG_REACTION:R00193
xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN
xref: RHEA:20716
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050271
name: obsolete S-alkylcysteine lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [GOC:curators]
comment: The reason for obsoletion is that this term is equivalent to GO:0047804 cysteine-S-conjugate beta-lyase activity.
is_obsolete: true
replaced_by: GO:0047804

[Term]
id: GO:0050272
name: S-carboxymethylcysteine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H+." [EC:4.5.1.5, RHEA:22868]
synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" RELATED [EC:4.5.1.5]
synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" RELATED [EC:4.5.1.5]
synonym: "S-carboxymethyl-L-cysteine synthase activity" RELATED [EC:4.5.1.5]
xref: EC:4.5.1.5
xref: KEGG_REACTION:R04003
xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN
xref: RHEA:22868
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0050273
name: S-succinylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + H+ + succinate." [EC:3.1.2.13, RHEA:16713]
xref: EC:3.1.2.13
xref: KEGG_REACTION:R00499
xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN
xref: RHEA:16713
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0050274
name: salicyl-alcohol beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H+ + salicin + UDP." [EC:2.4.1.172, RHEA:11512]
synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT []
synonym: "salicyl-alcohol glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.172]
synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" RELATED [EC:2.4.1.172]
synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.172]
synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" RELATED [EC:2.4.1.172]
xref: EC:2.4.1.172
xref: KEGG_REACTION:R03558
xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:11512
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050275
name: scopoletin glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: scopoletin + UDP-D-glucose = H+ + scopolin + UDP." [EC:2.4.1.128, RHEA:20453]
synonym: "SGTase activity" RELATED [EC:2.4.1.128]
synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.128]
synonym: "UDPglucose:scopoletin glucosyltransferase activity" RELATED [EC:2.4.1.128]
synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.128]
synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" RELATED [EC:2.4.1.128]
xref: EC:2.4.1.128
xref: KEGG_REACTION:R03594
xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:20453
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050276
name: scyllo-inosamine 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H+." [EC:2.7.1.65, RHEA:18605]
synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" RELATED [EC:2.7.1.65]
synonym: "ATP:inosamine phosphotransferase activity" RELATED [EC:2.7.1.65]
synonym: "scyllo-inosamine kinase (phosphorylating)" RELATED [EC:2.7.1.65]
synonym: "scyllo-inosamine kinase activity" EXACT []
xref: EC:2.7.1.65
xref: KEGG_REACTION:R03384
xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN
xref: RHEA:18605
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050277
name: sedoheptulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23844]
synonym: "ATP:sedoheptulose 7-phosphotransferase activity" RELATED [EC:2.7.1.14]
synonym: "heptulokinase activity" RELATED [EC:2.7.1.14]
synonym: "sedoheptulokinase (phosphorylating)" RELATED [EC:2.7.1.14]
xref: EC:2.7.1.14
xref: KEGG_REACTION:R01844
xref: MetaCyc:SEDOHEPTULOKINASE-RXN
xref: Reactome:R-HSA-8959719 "SHPK phosphorylates Sedo to Sedo7P"
xref: RHEA:23844
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050278
name: sedoheptulose-bisphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN]
synonym: "SBPase activity" RELATED [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-bisphosphatase activity" RELATED [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-diphosphatase activity" RELATED [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-diphosphate phosphatase activity" RELATED [EC:3.1.3.37]
synonym: "sedoheptulose bisphosphatase activity" RELATED [EC:3.1.3.37]
synonym: "sedoheptulose diphosphatase activity" RELATED [EC:3.1.3.37]
synonym: "sedoheptulose-1,7-bisphosphatase activity" RELATED [EC:3.1.3.37]
synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.37]
xref: EC:3.1.3.37
xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN
xref: RHEA:17461
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050279
name: sepiapterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN]
synonym: "sepiapterin aminohydrolase activity" RELATED [EC:3.5.4.24]
xref: EC:3.5.4.24
xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN
xref: RHEA:14025
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050280
name: sequoyitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADH." [EC:1.1.1.143, RHEA:11300]
synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.143]
xref: EC:1.1.1.143
xref: KEGG_REACTION:R03497
xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN
xref: RHEA:11300
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050281
name: L-serine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45]
synonym: "L-serine:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.45]
synonym: "serine--glyoxylate aminotransferase activity" EXACT []
synonym: "SGAT activity" RELATED [EC:2.6.1.45]
xref: EC:2.6.1.45
xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN
xref: RHEA:19125
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050282
name: serine 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN]
synonym: "L-serine:NAD oxidoreductase (deaminating) activity" RELATED [EC:1.4.1.7]
synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" RELATED [EC:1.4.1.7]
synonym: "serine dehydrogenase activity" EXACT []
xref: EC:1.4.1.7
xref: MetaCyc:SERINE-DEHYDROGENASE-RXN
xref: RHEA:20884
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050283
name: serine-sulfate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN]
synonym: "(L-SOS)lyase activity" RELATED [EC:4.3.1.10]
synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" RELATED [EC:4.3.1.10]
synonym: "serine-sulphate ammonia-lyase activity" EXACT []
xref: EC:4.3.1.10
xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN
xref: RHEA:15605
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0050284
name: sinapate 1-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" RELATED [EC:2.4.1.120]
synonym: "UDPglucose:sinapate D-glucosyltransferase activity" RELATED [EC:2.4.1.120]
synonym: "UDPglucose:sinapic acid glucosyltransferase activity" RELATED [EC:2.4.1.120]
synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" RELATED [EC:2.4.1.120]
synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" RELATED [EC:2.4.1.120]
xref: EC:2.4.1.120
xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:13305
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050285
name: sinapine esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-sinapoylcholine + H2O = choline + H+ + sinapate." [EC:3.1.1.49, RHEA:10016]
synonym: "aromatic choline esterase activity" RELATED [EC:3.1.1.49]
synonym: "sinapoylcholine sinapohydrolase activity" RELATED [EC:3.1.1.49]
xref: EC:3.1.1.49
xref: KEGG_REACTION:R02381
xref: MetaCyc:SINAPINE-ESTERASE-RXN
xref: RHEA:10016
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050286
name: sorbitol-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate." [EC:3.1.3.50, RHEA:24580]
synonym: "sorbitol-6-phosphate phosphatase activity" RELATED [EC:3.1.3.50]
synonym: "sorbitol-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.50]
xref: EC:3.1.3.50
xref: KEGG_REACTION:R02866
xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN
xref: RHEA:24580
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050287
name: sorbose 5-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + H+ + NADPH." [EC:1.1.1.123, RHEA:15001]
synonym: "5-keto-D-fructose reductase activity" RELATED [EC:1.1.1.123]
synonym: "5-ketofructose reductase activity" RELATED [EC:1.1.1.123]
synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" RELATED [EC:1.1.1.123]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" RELATED [EC:1.1.1.123]
synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.123]
xref: EC:1.1.1.123
xref: KEGG_REACTION:R01694
xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN
xref: RHEA:15001
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050288
name: sorbose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.12, RHEA:14713]
synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" RELATED [EC:1.1.99.12]
synonym: "L-sorbose:acceptor 5-oxidoreductase activity" RELATED [EC:1.1.99.12]
xref: EC:1.1.99.12
xref: KEGG_REACTION:R01696
xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN
xref: RHEA:14713
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050289
name: spermidine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN]
synonym: "spermidine:(acceptor) oxidoreductase activity" RELATED [EC:1.5.99.6]
synonym: "spermidine:acceptor oxidoreductase activity" RELATED [EC:1.5.99.6]
xref: EC:1.5.99.6
xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN
xref: RHEA:14273
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050290
name: sphingomyelin phosphodiesterase D activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+." [EC:3.1.4.41, RHEA:20984]
synonym: "sphingomyelin ceramide-phosphohydrolase activity" RELATED [EC:3.1.4.41]
synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41]
xref: EC:3.1.4.41
xref: KEGG_REACTION:R02542
xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN
xref: RHEA:20984
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0050291
name: sphingosine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]
synonym: "acyl-CoA:sphingosine N-acyltransferase activity" RELATED [EC:2.3.1.24]
synonym: "ceramide synthase activity" EXACT []
synonym: "ceramide synthetase activity" RELATED [EC:2.3.1.24]
synonym: "dihydroceramide synthase activity" EXACT []
synonym: "sphingosine acyltransferase activity" RELATED [EC:2.3.1.24]
xref: EC:2.3.1.24
xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN
xref: Reactome:R-HSA-428185 "Ceramide synthases transfer acyl-CoA onto sphingoid"
xref: RHEA:23768
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0050292
name: steroid 9-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O." [RHEA:19557]
synonym: "steroid 9-alpha-hydroxylase activity" RELATED [EC:1.14.99.24]
synonym: "steroid 9a-monooxygenase activity" EXACT []
synonym: "steroid 9alpha-hydroxylase activity" RELATED [EC:1.14.99.24]
synonym: "steroid 9alpha-monooxygenase activity" RELATED [EC:1.14.99.24]
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" RELATED [EC:1.14.99.24]
xref: EC:1.14.99.24
xref: KEGG_REACTION:R04392
xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN
xref: RHEA:19557
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050293
name: steroid-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + testololactone = H+ + testolate." [EC:3.1.1.37, RHEA:13721]
synonym: "testololactone lactonohydrolase activity" RELATED [EC:3.1.1.37]
xref: EC:3.1.1.37
xref: KEGG_REACTION:R03641
xref: MetaCyc:STEROID-LACTONASE-RXN
xref: RHEA:13721
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050294
name: steroid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [MetaCyc:STEROID-SULFOTRANSFERASE-RXN, RHEA:68460]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" RELATED [EC:2.8.2.15]
synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15]
synonym: "steroid sulphotransferase activity" EXACT []
xref: EC:2.8.2.15
xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-176517 "SULTs transfer (SO4)2- group to PREG"
xref: Reactome:R-HSA-176521 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP"
xref: Reactome:R-HSA-176631 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP"
xref: RHEA:68460
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050295
name: steryl-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol." [EC:3.2.1.104, RHEA:11956]
synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" RELATED [EC:3.2.1.104]
synonym: "steryl-b-glucosidase activity" EXACT []
xref: EC:3.2.1.104
xref: KEGG_REACTION:R01460
xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN
xref: RHEA:11956
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050296
name: stipitatonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + stipitatonate = CO2 + H+ + stipitatate." [EC:4.1.1.60, RHEA:13885]
synonym: "stipitatonate carboxy-lyase (decyclizing)" RELATED [EC:4.1.1.60]
synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" RELATED [EC:4.1.1.60]
xref: EC:4.1.1.60
xref: KEGG_REACTION:R03739
xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN
xref: RHEA:13885
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050297
name: stizolobate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H+." [RHEA:21220]
synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" RELATED [EC:1.13.11.29]
synonym: "DOPA dioxygenase activity" EXACT []
xref: EC:1.13.11.29
xref: MetaCyc:RXN-8460
xref: RHEA:21220
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050298
name: stizolobinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN]
synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" RELATED [EC:1.13.11.30]
xref: EC:1.13.11.30
xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN
xref: RHEA:18465
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050299
name: streptomycin 3''-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 3''-phosphate." [EC:2.7.1.87, RHEA:18377]
synonym: "ATP:streptomycin 3''-phosphotransferase activity" RELATED [EC:2.7.1.87]
synonym: "streptomycin 3''-kinase (phosphorylating)" RELATED [EC:2.7.1.87]
synonym: "streptomycin 3''-phosphotransferase activity" RELATED [EC:2.7.1.87]
xref: EC:2.7.1.87
xref: KEGG_REACTION:R02227
xref: MetaCyc:STREPTOMYCIN-3-KINASE-RXN
xref: RHEA:18377
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0050300
name: aminoglycoside 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 6-phosphate." [EC:2.7.1.72, RHEA:22268]
synonym: "APH(6) activity" RELATED [EC:2.7.1.72]
synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72]
synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72]
synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72]
synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-kinase activity" NARROW []
synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72]
xref: EC:2.7.1.72
xref: KEGG_REACTION:R02225
xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN
xref: RHEA:22268
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0050301
name: streptomycin-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin." [EC:3.1.3.39, RHEA:10688]
synonym: "streptomycin 6-phosphate phosphatase activity" RELATED [EC:3.1.3.39]
synonym: "streptomycin 6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.39]
synonym: "streptomycin-6-P phosphohydrolase activity" RELATED [EC:3.1.3.39]
synonym: "streptomycin-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.39]
xref: EC:3.1.3.39
xref: KEGG_REACTION:R02228
xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN
xref: RHEA:10688
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050302
name: indole-3-acetaldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H+ + H2O2." [RHEA:16277]
synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.7]
synonym: "AO1" RELATED [EC:1.2.3.7]
synonym: "IAA oxidase activity" RELATED [EC:1.2.3.7]
synonym: "IAAld oxidase activity" RELATED [EC:1.2.3.7]
synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.7]
synonym: "indoleacetaldehyde oxidase activity" RELATED [EC:1.2.3.7]
xref: EC:1.2.3.7
xref: KEGG_REACTION:R02681
xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN
xref: RHEA:16277
is_a: GO:0018488 ! aryl-aldehyde oxidase activity

[Term]
id: GO:0050303
name: lysine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN, RHEA:12408]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "L-lysine 6-dehydrogenase activity" RELATED [EC:1.4.1.18]
synonym: "L-lysine epsilon-dehydrogenase activity" RELATED [EC:1.4.1.18]
synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" RELATED [EC:1.4.1.18]
synonym: "LysDH activity" RELATED [EC:1.4.1.18]
xref: EC:1.4.1.18
xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN
xref: RHEA:12408
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050304
name: nitrous-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide." [EC:1.7.2.4, MetaCyc:RXN-12130]
synonym: "N2O reductase activity" RELATED [EC:1.7.2.4]
synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" RELATED [EC:1.7.2.4]
synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" RELATED [EC:1.7.2.4]
synonym: "nitrous oxide reductase activity" RELATED [EC:1.7.2.4]
xref: EC:1.7.2.4
xref: KEGG_REACTION:R02804
xref: MetaCyc:RXN-12130
xref: RHEA:43108
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0050305
name: strombine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H2O + NAD+ = glycine + H+ + NADH + pyruvate." [EC:1.5.1.22, RHEA:14061]
synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" RELATED [EC:1.5.1.22]
synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" RELATED [EC:1.5.1.22]
synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" RELATED [EC:1.5.1.22]
xref: EC:1.5.1.22
xref: KEGG_REACTION:R00368
xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN
xref: RHEA:14061
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050306
name: sucrose 1F-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99]
synonym: "SST activity" RELATED [EC:2.4.1.99]
synonym: "sucrose 1(F)-fructosyltransferase activity" RELATED [EC:2.4.1.99]
synonym: "sucrose-sucrose 1-fructosyltransferase activity" RELATED [EC:2.4.1.99]
synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.99]
synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.99]
synonym: "sucrose:sucrose 1-fructosyltransferase activity" RELATED [EC:2.4.1.99]
synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.99]
synonym: "sucrose:sucrose fructosyltransferase activity" RELATED [EC:2.4.1.99]
xref: EC:2.4.1.99
xref: MetaCyc:RXN-1781
xref: RHEA:23312
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0050307
name: sucrose-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN]
synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.24]
synonym: "sucrose-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.24]
xref: EC:3.1.3.24
xref: KEGG_REACTION:R00805
xref: KEGG_REACTION:R06211
xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN
xref: RHEA:19289
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0050308
name: sugar-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN]
synonym: "sugar-phosphate phosphatase activity" EXACT []
synonym: "sugar-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.23]
xref: EC:3.1.3.23
xref: KEGG_REACTION:R00804
xref: MetaCyc:SUGAR-PHOSPHATASE-RXN
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0050309
name: sugar-terminal-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate." [EC:3.1.3.58]
synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.58]
synonym: "xylitol-5-phosphatase activity" NARROW [EC:3.1.3.58]
xref: EC:3.1.3.58
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0050310
name: sulfite dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN]
synonym: "sulfite cytochrome c reductase activity" RELATED [EC:1.8.2.1]
synonym: "sulfite-cytochrome c oxidoreductase activity" RELATED [EC:1.8.2.1]
synonym: "sulfite:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.8.2.1]
synonym: "sulphite dehydrogenase activity" EXACT []
xref: EC:1.8.2.1
xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN
xref: RHEA:14281
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0050311
name: sulfite reductase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN]
synonym: "ferredoxin-sulfite reductase activity" RELATED [EC:1.8.7.1]
synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" RELATED [EC:1.8.7.1]
synonym: "sulphite reductase (ferredoxin) activity" EXACT []
xref: EC:1.8.7.1
xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN
xref: RHEA:23132
is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050312
name: obsolete sulfoacetaldehyde lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN]
comment: The reason for obsoletion is that the term was based on the deleted EC:4.4.1.12 as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15).
synonym: "sulphoacetaldehyde lyase activity" EXACT []
is_obsolete: true
consider: GO:0050487

[Term]
id: GO:0050313
name: sulfur dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+." [EC:1.13.11.18]
synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" RELATED [EC:1.13.11.18]
synonym: "sulfur oxygenase activity" RELATED [EC:1.13.11.18]
synonym: "sulfur:oxygen oxidoreductase activity" RELATED [EC:1.13.11.18]
synonym: "sulphur dioxygenase activity" EXACT []
xref: EC:1.13.11.18
xref: MetaCyc:RXN-13161
xref: Reactome:R-HSA-1614605 "Persulfide sulfur is dioxygenated"
xref: RHEA:12981
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050314
name: sym-norspermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H+." [EC:2.5.1.23, RHEA:23244]
synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" RELATED [EC:2.5.1.23]
xref: EC:2.5.1.23
xref: KEGG_REACTION:R03271
xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN
xref: RHEA:23244
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050315
name: synephrine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium." [EC:4.2.1.88, RHEA:32203]
synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" RELATED [EC:4.2.1.88]
xref: EC:4.2.1.88
xref: KEGG_REACTION:R03359
xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN
xref: RHEA:32203
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050316
name: T2-induced deoxynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP." [EC:2.7.4.12]
synonym: "ATP:(d)NMP phosphotransferase activity" RELATED [EC:2.7.4.12]
xref: EC:2.7.4.12
xref: MetaCyc:GMKALT-RXN
xref: RHEA:12697
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0050317
name: tagatose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H+." [EC:2.7.1.101, RHEA:15513]
synonym: "ATP:D-tagatose 6-phosphotransferase activity" RELATED [EC:2.7.1.101]
synonym: "D-tagatose 6-phosphate kinase activity" RELATED [EC:2.7.1.101]
synonym: "tagatose 6-phosphate kinase (phosphorylating)" RELATED [EC:2.7.1.101]
xref: EC:2.7.1.101
xref: KEGG_REACTION:R02927
xref: MetaCyc:TAGATOSE-KINASE-RXN
xref: RHEA:15513
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050318
name: tannase activity
namespace: molecular_function
def: "Catalysis of the reaction: digallate + H2O = 2 gallate + H+." [EC:3.1.1.20, RHEA:16365]
synonym: "tannase S" RELATED [EC:3.1.1.20]
synonym: "tannin acetylhydrolase activity" RELATED [EC:3.1.1.20]
synonym: "tannin acylhydrolase activity" RELATED [EC:3.1.1.20]
xref: EC:3.1.1.20
xref: KEGG_REACTION:R00053
xref: MetaCyc:TANNASE-RXN
xref: RHEA:16365
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050319
name: tartrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tartrate + H+ = D-glycerate + CO2." [EC:4.1.1.73, RHEA:13317]
synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" RELATED [EC:4.1.1.73]
synonym: "(R,R)-tartrate carboxy-lyase activity" RELATED [EC:4.1.1.73]
xref: EC:4.1.1.73
xref: KEGG_REACTION:R01751
xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN
xref: RHEA:13317
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050320
name: tartrate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate." [EC:5.1.2.5, RHEA:22212]
synonym: "tartaric racemase activity" RELATED [EC:5.1.2.5]
xref: EC:5.1.2.5
xref: KEGG_REACTION:R02546
xref: MetaCyc:TARTRATE-EPIMERASE-RXN
xref: RHEA:22212
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0050321
name: tau-protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein on serine and threonine residues." [EC:2.7.11.26]
synonym: "[Tau protein] kinase activity" EXACT []
synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26]
synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26]
synonym: "cdk5/p20" RELATED [EC:2.7.11.26]
synonym: "CDK5/p23" RELATED [EC:2.7.11.26]
synonym: "glycogen synthase kinase-3beta activity" RELATED []
synonym: "GSK" RELATED [EC:2.7.11.26]
synonym: "protein tau kinase activity" RELATED [EC:2.7.11.26]
synonym: "STK31" RELATED [EC:2.7.11.26]
synonym: "tau kinase activity" RELATED [EC:2.7.11.26]
synonym: "tau protein kinase activity" RELATED [EC:2.7.11.26]
synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26]
synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26]
synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26]
synonym: "TPK" RELATED [EC:2.7.11.26]
synonym: "TPK I" RELATED [EC:2.7.11.26]
synonym: "TPK II" RELATED [EC:2.7.11.26]
synonym: "TTK" RELATED [EC:2.7.11.26]
xref: EC:2.7.11.26
xref: MetaCyc:TAU-PROTEIN-KINASE-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0050322
name: taurine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [PMID:16535664, RHEA:16353]
synonym: "taurine aminotransferase activity" EXACT []
synonym: "taurine transaminase activity" EXACT []
synonym: "taurine--alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.55]
synonym: "taurine--glutamate transaminase activity" RELATED [EC:2.6.1.55]
synonym: "taurine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.55]
xref: EC:2.6.1.55
xref: MetaCyc:RXN-2301
xref: RHEA:16353
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050323
name: taurine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H2O + taurine = AH(2) + NH4 + sulfoacetaldehyde." [PMID:15073291, RHEA:18709]
synonym: "taurine:(acceptor) oxidoreductase (deaminating)" RELATED [EC:1.4.99.2]
synonym: "taurine:acceptor oxidoreductase (deaminating)" RELATED [EC:1.4.99.2]
xref: EC:1.4.99.2
xref: KEGG_REACTION:R07167
xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN
xref: RHEA:18709
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0050324
name: taurocyamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H+." [EC:2.7.3.4, RHEA:22516]
synonym: "ATP:taurocyamine N-phosphotransferase activity" RELATED [EC:2.7.3.4]
synonym: "ATP:taurocyamine phosphotransferase activity" RELATED [EC:2.7.3.4]
synonym: "taurocyamine phosphotransferase activity" RELATED [EC:2.7.3.4]
xref: EC:2.7.3.4
xref: KEGG_REACTION:R03785
xref: MetaCyc:TAUROCYAMINE-KINASE-RXN
xref: RHEA:22516
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050325
name: tauropine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + tauropine = H+ + NADH + pyruvate + taurine." [EC:1.5.1.23, RHEA:12580]
synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" RELATED [EC:1.5.1.23]
synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" RELATED [EC:1.5.1.23]
xref: EC:1.5.1.23
xref: KEGG_REACTION:R01683
xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN
xref: RHEA:12580
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050326
name: taxifolin 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN]
synonym: "taxifolin hydroxylase activity" EXACT []
synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" RELATED [EC:1.14.13.19]
xref: EC:1.14.13.19
xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050328
name: tetrahydroberberine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN]
synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" RELATED [EC:1.3.3.8]
synonym: "(S)-THB oxidase activity" RELATED [EC:1.3.3.8]
synonym: "THB oxidase activity" RELATED [EC:1.3.3.8]
xref: EC:1.3.3.8
xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN
xref: RHEA:13489
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050329
name: tetrahydroxypteridine cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydroxypteridine = H+ + xanthine-8-carboxylate." [EC:5.5.1.3, RHEA:18097]
synonym: "tetrahydroxypteridine lyase (isomerizing)" RELATED [EC:5.5.1.3]
xref: EC:5.5.1.3
xref: KEGG_REACTION:R04154
xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN
xref: RHEA:18097
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0050330
name: theanine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine." [EC:3.5.1.65, RHEA:18013]
synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.65]
synonym: "L-theanine amidohydrolase activity" RELATED [EC:3.5.1.65]
synonym: "N5-ethyl-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.65]
xref: EC:3.5.1.65
xref: KEGG_REACTION:R02930
xref: MetaCyc:THEANINE-HYDROLASE-RXN
xref: RHEA:18013
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050331
name: thiamine-diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN]
synonym: "ATP:thiamin-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.15]
synonym: "ATP:thiamine-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.15]
synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" RELATED [EC:2.7.4.15]
synonym: "TDP kinase activity" RELATED [EC:2.7.4.15]
synonym: "thiamin diphosphate kinase activity" EXACT []
synonym: "thiamin diphosphate phosphotransferase activity" RELATED [EC:2.7.4.15]
synonym: "thiamin pyrophosphate kinase activity" RELATED [EC:2.7.4.15]
synonym: "thiamin-diphosphate kinase activity" EXACT []
synonym: "thiamine diphosphate kinase activity" RELATED [EC:2.7.4.15]
xref: EC:2.7.4.15
xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN
xref: Reactome:R-HSA-997381 "TDPK phosphorylates ThDP to ThTP"
xref: RHEA:11240
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0050332
name: thiamine pyridinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine." [EC:2.5.1.2, RHEA:17697]
synonym: "pyrimidine transferase activity" RELATED [EC:2.5.1.2]
synonym: "thiamin hydrolase activity" RELATED [EC:2.5.1.2]
synonym: "thiamin pyridinolase activity" RELATED [EC:2.5.1.2]
synonym: "thiamin pyridinylase activity" EXACT []
synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" RELATED [EC:2.5.1.2]
synonym: "thiaminase I activity" NARROW [EC:2.5.1.2]
synonym: "thiamine hydrolase activity" RELATED [EC:2.5.1.2]
synonym: "thiamine pyridinolase activity" RELATED [EC:2.5.1.2]
synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" RELATED [EC:2.5.1.2]
xref: EC:2.5.1.2
xref: KEGG_REACTION:R02863
xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN
xref: RHEA:17697
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050333
name: thiamine triphosphate phosphatase activity
namespace: molecular_function
alt_id: GO:0048253
def: "Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate." [RHEA:11744]
synonym: "thiamin-triphosphatase activity" RELATED []
synonym: "thiamine triphosphatase activity" RELATED []
synonym: "thiamine-triphosphatase activity" RELATED []
synonym: "thiamine-triphosphate phosphohydrolase activity" RELATED [EC:3.6.1.28]
synonym: "ThTPase activity" RELATED [EC:3.6.1.28]
xref: EC:3.6.1.28
xref: KEGG_REACTION:R00618
xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN
xref: Reactome:R-HSA-965067 "THTPA:Mg2+ hydrolyzes ThTP to TDP"
xref: RHEA:11744
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050334
name: thiaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+." [EC:3.5.99.2, RHEA:17509]
synonym: "thiaminase II activity" NARROW [EC:3.5.99.2]
xref: EC:3.5.99.2
xref: KEGG_REACTION:R02133
xref: MetaCyc:THIAMINASE-RXN
xref: RHEA:17509
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050335
name: thiocyanate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, RHEA:10004]
synonym: "benzyl-thiocyanate isomerase activity" RELATED [EC:5.99.1.1]
synonym: "isothiocyanate isomerase activity" RELATED [EC:5.99.1.1]
xref: EC:5.99.1.1
xref: KEGG_REACTION:R04010
xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN
xref: RHEA:10004
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0050336
name: thioethanolamine S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA." [EC:2.3.1.11, RHEA:23280]
synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" RELATED [EC:2.3.1.11]
synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" RELATED [EC:2.3.1.11]
synonym: "thioethanolamine acetyltransferase activity" RELATED [EC:2.3.1.11]
synonym: "thioltransacetylase B activity" RELATED [EC:2.3.1.11]
xref: EC:2.3.1.11
xref: KEGG_REACTION:R03668
xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN
xref: RHEA:23280
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0050337
name: thiosulfate-thiol sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN]
synonym: "glutathione-dependent thiosulfate reductase activity" RELATED [EC:2.8.1.3]
synonym: "sulfane reductase activity" RELATED [EC:2.8.1.3]
synonym: "sulfane sulfurtransferase activity" RELATED [EC:2.8.1.3]
synonym: "thiosulfate:thiol sulfurtransferase activity" RELATED [EC:2.8.1.3]
synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT []
xref: EC:2.8.1.3
xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN
xref: Reactome:R-HSA-1655879 "Thiosulfate can transfer its sulfur atom to glutathione"
xref: RHEA:14505
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0050338
name: thiosulfate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN]
synonym: "tetrathionate synthase activity" RELATED [EC:1.8.2.2]
synonym: "thiosulfate oxidase activity" RELATED [EC:1.8.2.2]
synonym: "thiosulfate-acceptor oxidoreductase activity" RELATED [EC:1.8.2.2]
synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2]
synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.8.2.2]
synonym: "thiosulphate dehydrogenase activity" EXACT []
xref: EC:1.8.2.2
xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN
xref: RHEA:20549
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0050339
name: TTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + H2O = dTDP + H+ + phosphate." [RHEA:19013]
synonym: "deoxythymidine-5'-triphosphatase activity" RELATED [EC:3.6.1.39]
synonym: "dTTP nucleotidohydrolase activity" RELATED [EC:3.6.1.39]
synonym: "dTTPase activity" RELATED [EC:3.6.1.39]
synonym: "thymidine triphosphatase activity" EXACT []
synonym: "thymidine triphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.39]
synonym: "thymidine-triphosphatase activity" EXACT []
xref: EC:3.6.1.39
xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN
xref: RHEA:19013
is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity

[Term]
id: GO:0050340
name: thymidylate 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN]
synonym: "deoxythymidylate 5'-nucleotidase activity" RELATED [EC:3.1.3.35]
synonym: "deoxythymidylate phosphohydrolase activity" RELATED [EC:3.1.3.35]
synonym: "deoxythymidylic 5'-nucleotidase activity" RELATED [EC:3.1.3.35]
synonym: "dTMPase activity" RELATED [EC:3.1.3.35]
synonym: "thymidylate 5' phosphatase activity" EXACT []
synonym: "thymidylate 5'-nucleotidase activity" RELATED [EC:3.1.3.35]
synonym: "thymidylate 5'-phosphohydrolase activity" RELATED [EC:3.1.3.35]
synonym: "thymidylate nucleotidase activity" RELATED [EC:3.1.3.35]
xref: EC:3.1.3.35
xref: MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN
xref: RHEA:11080
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0050341
name: thymine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN]
synonym: "5-hydroxy-methyluracil dioxygenase activity" RELATED [EC:1.14.11.6]
synonym: "5-hydroxymethyluracil oxygenase activity" RELATED [EC:1.14.11.6]
synonym: "thymine 7-hydroxylase activity" RELATED [EC:1.14.11.6]
synonym: "thymine,2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.6]
synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" RELATED [EC:1.14.11.6]
xref: EC:1.14.11.6
xref: MetaCyc:THYMINE-DIOXYGENASE-RXN
xref: RHEA:10316
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0050342
name: tocopherol C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H+ + S-adenosyl-L-homocysteine. This reaction can also use delta-tocopherol, gamma-tocotrienol and delta-tocotrienol as substrates." [EC:2.1.1.95]
synonym: "gamma-tocopherol methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" RELATED [EC:2.1.1.95]
synonym: "tocopherol O-methyltransferase activity" EXACT []
xref: EC:2.1.1.95
xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0050343
name: trans-2-enoyl-CoA reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44]
synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" RELATED [EC:1.3.1.44]
xref: EC:1.3.1.44
xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN
xref: RHEA:18177
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050344
name: trans-cinnamate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + H+ + NADPH + O2 = 2-coumarate + H2O + NADP+." [EC:1.14.13.14, RHEA:10956]
synonym: "cinnamate 2-hydroxylase activity" RELATED [EC:1.14.13.14]
synonym: "cinnamate 2-monooxygenase activity" RELATED [EC:1.14.13.14]
synonym: "cinnamic 2-hydroxylase activity" RELATED [EC:1.14.13.14]
synonym: "cinnamic acid 2-hydroxylase activity" RELATED [EC:1.14.13.14]
synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.14]
synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT []
xref: EC:1.14.13.14
xref: KEGG_REACTION:R02254
xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN
xref: RHEA:10956
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050345
name: trans-epoxysuccinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate." [EC:3.3.2.4, RHEA:20740]
synonym: "tartrate epoxydase activity" RELATED [EC:3.3.2.4]
synonym: "trans-2,3-epoxysuccinate hydrolase activity" RELATED [EC:3.3.2.4]
synonym: "trans-epoxysuccinate hydratase activity" RELATED [EC:3.3.2.4]
xref: EC:3.3.2.4
xref: KEGG_REACTION:R02547
xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN
xref: RHEA:20740
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0050346
name: trans-L-3-hydroxyproline dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+." [EC:4.2.1.77, RHEA:10320]
synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" RELATED [EC:4.2.1.77]
synonym: "trans-L-3-hydroxyproline hydro-lyase activity" RELATED [EC:4.2.1.77]
xref: EC:4.2.1.77
xref: KEGG_REACTION:R04374
xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN
xref: RHEA:10320
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050348
name: trehalose O-mycolyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose." [EC:2.3.1.122, RHEA:23472]
synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" RELATED [EC:2.3.1.122]
synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" RELATED [EC:2.3.1.122]
xref: EC:2.3.1.122
xref: KEGG_REACTION:R07248
xref: MetaCyc:RXN1G-874
xref: RHEA:23472
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050349
name: triacetate-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + triacetate lactone = triacetate." [EC:3.1.1.38, RHEA:22260]
synonym: "TAL hydrolase activity" RELATED [EC:3.1.1.38]
synonym: "triacetate lactone hydrolase activity" RELATED [EC:3.1.1.38]
synonym: "triacetic acid lactone hydrolase activity" RELATED [EC:3.1.1.38]
synonym: "triacetic lactone hydrolase activity" RELATED [EC:3.1.1.38]
synonym: "triacetolactone lactonohydrolase activity" RELATED [EC:3.1.1.38]
xref: EC:3.1.1.38
xref: KEGG_REACTION:R03702
xref: MetaCyc:RXN-20777
xref: RHEA:22260
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050350
name: trihydroxystilbene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95]
synonym: "resveratrol synthase activity" RELATED [EC:2.3.1.95]
synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95]
xref: EC:2.3.1.95
xref: MetaCyc:RXN-87
xref: RHEA:11936
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050351
name: trimetaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + trimetaphosphate = 2 H+ + triphosphate." [EC:3.6.1.2, RHEA:11088]
synonym: "inorganic trimetaphosphatase activity" RELATED [EC:3.6.1.2]
synonym: "trimetaphosphate hydrolase activity" RELATED [EC:3.6.1.2]
xref: EC:3.6.1.2
xref: KEGG_REACTION:R02504
xref: MetaCyc:TRIMETAPHOSPHATASE-RXN
xref: RHEA:11088
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0050352
name: trimethylamine-oxide aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + trimethylamine N-oxide = dimethylamine + formaldehyde." [EC:4.1.2.32, RHEA:20217]
synonym: "trimethylamine N-oxide aldolase activity" RELATED [EC:4.1.2.32]
synonym: "trimethylamine N-oxide demethylase activity" RELATED [EC:4.1.2.32]
synonym: "trimethylamine N-oxide formaldehyde-lyase activity" RELATED [EC:4.1.2.32]
synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" RELATED [EC:4.1.2.32]
synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" RELATED [EC:4.1.2.32]
xref: EC:4.1.2.32
xref: KEGG_REACTION:R02512
xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN
xref: RHEA:20217
xref: UM-BBD_reactionID:r1409
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050353
name: trimethyllysine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate." [EC:1.14.11.8, RHEA:14181]
synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.8]
synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.8]
synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.8]
synonym: "TML dioxygenase activity" RELATED [EC:1.14.11.8]
synonym: "TML hydroxylase activity" RELATED [EC:1.14.11.8]
synonym: "TML-alpha-ketoglutarate dioxygenase activity" RELATED [EC:1.14.11.8]
synonym: "TMLD activity" RELATED [EC:1.14.11.8]
synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" RELATED [EC:1.14.11.8]
synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.8]
xref: EC:1.14.11.8
xref: KEGG_REACTION:R03451
xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN
xref: Reactome:R-HSA-71241 "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA"
xref: RHEA:14181
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0050354
name: triokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+." [EC:2.7.1.28, RHEA:13941]
synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" RELATED [EC:2.7.1.28]
synonym: "D-triokinase activity" RELATED [EC:2.7.1.28]
synonym: "trio triose kinase (phosphorylating)" RELATED [EC:2.7.1.28]
synonym: "triose kinase activity" RELATED [EC:2.7.1.28]
xref: EC:2.7.1.28
xref: KEGG_REACTION:R01059
xref: MetaCyc:TRIOKINASE-RXN
xref: Reactome:R-HSA-70349 "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate"
xref: RHEA:13941
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050355
name: inorganic triphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate." [EC:3.6.1.25, RHEA:14157]
synonym: "inorganic triphosphatase activity" RELATED [EC:3.6.1.25]
synonym: "triphosphatase activity" BROAD []
synonym: "triphosphate phosphohydrolase activity" RELATED [EC:3.6.1.25]
synonym: "tripolyphosphatase activity" EXACT [PMID:24004165]
xref: EC:3.6.1.25
xref: KEGG_REACTION:R00138
xref: MetaCyc:TRIPHOSPHATASE-RXN
xref: RHEA:14157
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050356
name: tropine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + tropine = H+ + NADPH + tropinone." [EC:1.1.1.206, RHEA:18357]
synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" RELATED [EC:1.1.1.206]
xref: EC:1.1.1.206
xref: KEGG_REACTION:R02832
xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN
xref: RHEA:18357
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050357
name: tropinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: atropine + H2O = H+ + tropate + tropine." [EC:3.1.1.10, RHEA:23304]
synonym: "atropinase activity" RELATED [EC:3.1.1.10]
synonym: "atropine acylhydrolase activity" RELATED [EC:3.1.1.10]
synonym: "atropine esterase activity" RELATED [EC:3.1.1.10]
synonym: "atropinesterase activity" RELATED [EC:3.1.1.10]
synonym: "tropine esterase activity" RELATED [EC:3.1.1.10]
xref: EC:3.1.1.10
xref: KEGG_REACTION:R03563
xref: MetaCyc:TROPINESTERASE-RXN
xref: RHEA:23304
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050358
name: tropinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + pseudotropine = H+ + NADPH + tropinone." [EC:1.1.1.236, RHEA:24244]
synonym: "pseudotropine forming tropinone reductase activity" RELATED [EC:1.1.1.236]
synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.236]
synonym: "tropinone (psi-tropine-forming) reductase activity" RELATED [EC:1.1.1.236]
synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236]
xref: EC:1.1.1.236
xref: KEGG_REACTION:R06734
xref: MetaCyc:TROPINONE-REDUCTASE-RXN
xref: RHEA:24244
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050359
name: obsolete tropomyosin kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [MetaCyc:TROPOMYOSIN-KINASE-RXN]
comment: The reason for obsoletion is that there are no proteins associated with this EC, and this reaction is not found in RHEA.
synonym: "ATP:tropomyosin O-phosphotransferase activity" RELATED []
synonym: "STK" RELATED []
synonym: "tropomyosin kinase (phosphorylating) activity" RELATED []
is_obsolete: true

[Term]
id: GO:0050360
name: tryptophan 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN]
synonym: "indole-3-alkane alpha-hydroxylase activity" RELATED [EC:1.13.99.3]
synonym: "indolyl-3-alkan alpha-hydroxylase activity" RELATED [EC:1.13.99.3]
synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" RELATED [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase activity" RELATED [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3]
synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3]
synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3]
synonym: "TSO activity" RELATED [EC:1.13.99.3]
synonym: "TSO I" RELATED [EC:1.13.99.3]
synonym: "TSO II" RELATED [EC:1.13.99.3]
xref: EC:1.13.99.3
xref: MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN
xref: RHEA:22620
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0050361
name: tryptophan 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide." [EC:1.13.12.3, RHEA:16165]
synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.3]
xref: EC:1.13.12.3
xref: KEGG_REACTION:R00679
xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN
xref: RHEA:16165
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050362
name: L-tryptophan:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN]
synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" RELATED [EC:2.6.1.27]
synonym: "hydroxytryptophan aminotransferase activity" RELATED [EC:2.6.1.27]
synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.27]
synonym: "L-tryptophan aminotransferase activity" BROAD [EC:2.6.1.27]
synonym: "L-tryptophan transaminase activity" BROAD [EC:2.6.1.27]
synonym: "tryptophan aminotransferase activity" EXACT []
synonym: "tryptophan transaminase activity" BROAD [EC:2.6.1.27]
xref: EC:2.6.1.27
xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN
xref: RHEA:14093
is_a: GO:0070529 ! L-tryptophan aminotransferase activity

[Term]
id: GO:0050363
name: tryptophan dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN]
synonym: "L-Trp-dehydrogenase activity" RELATED [EC:1.4.1.19]
synonym: "L-tryptophan dehydrogenase activity" RELATED [EC:1.4.1.19]
synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.19]
synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" RELATED [EC:1.4.1.19]
synonym: "TDH" RELATED [EC:1.4.1.19]
synonym: "TrpDH activity" RELATED [EC:1.4.1.19]
xref: EC:1.4.1.19
xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050364
name: tryptophan dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN]
synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" RELATED [EC:2.5.1.34]
synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" RELATED [EC:2.5.1.34]
synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" RELATED [EC:2.5.1.34]
synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" RELATED [EC:2.5.1.34]
synonym: "dimethylallyltryptophan synthetase activity" RELATED [EC:2.5.1.34]
synonym: "DMAT synthetase activity" RELATED [EC:2.5.1.34]
xref: EC:2.5.1.34
xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN
xref: RHEA:14173
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050365
name: tryptophanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH4." [EC:3.5.1.57, RHEA:11012]
synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57]
synonym: "L-tryptophanamide amidohydrolase activity" RELATED [EC:3.5.1.57]
synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57]
xref: EC:3.5.1.57
xref: KEGG_REACTION:R00682
xref: MetaCyc:TRYPTOPHANAMIDASE-RXN
xref: RHEA:11012
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050366
name: tyramine N-feruloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN]
synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" RELATED [EC:2.3.1.110]
synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.110]
synonym: "feruloyltyramine synthase activity" RELATED [EC:2.3.1.110]
synonym: "tyramine feruloyltransferase activity" RELATED [EC:2.3.1.110]
synonym: "tyramine N-feruloyl-CoA transferase activity" RELATED [EC:2.3.1.110]
xref: EC:2.3.1.110
xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN
xref: RHEA:19685
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050367
name: tyrosine-arginine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H+." [EC:6.3.2.24, RHEA:15345]
synonym: "kyotorphin synthase activity" RELATED [EC:6.3.2.24]
synonym: "kyotorphin synthetase activity" RELATED [EC:6.3.2.24]
synonym: "kyotorphin-synthesizing enzyme activity" RELATED [EC:6.3.2.24]
synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" RELATED [EC:6.3.2.24]
synonym: "tyrosyl-arginine synthase activity" RELATED [EC:6.3.2.24]
xref: EC:6.3.2.24
xref: KEGG_REACTION:R00735
xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN
xref: RHEA:15345
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050368
name: L-tyrosine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [RHEA:15781]
synonym: "tyrosine 2,3-aminomutase activity" RELATED []
synonym: "tyrosine alpha,beta-mutase activity" RELATED [EC:5.4.3.6]
xref: EC:5.4.3.6
xref: KEGG_REACTION:R00739
xref: MetaCyc:TYROSINE-23-AMINOMUTASE-RXN
xref: RHEA:15781
is_a: GO:0016869 ! intramolecular aminotransferase activity

[Term]
id: GO:0050369
name: [tyrosine 3-monooxygenase] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-seryl-[tyrosine-3-monooxygenase] = ADP + H+ + O-phospho-L-seryl-[tyrosine-3-monooxygenase]." [EC:2.7.11.6]
synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" RELATED [EC:2.7.11.6]
synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" RELATED [EC:2.7.11.6]
synonym: "STK4" RELATED [EC:2.7.11.6]
synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.6]
synonym: "tyrosine 3-monooxygenase kinase activity" EXACT []
xref: EC:2.7.11.6
xref: MetaCyc:2.7.11.6-RXN
xref: RHEA:17133
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0050370
name: tyrosine N-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN]
synonym: "CYP79A1 activity" NARROW []
synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT []
synonym: "tyrosine N-hydroxylase activity" EXACT []
xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN
xref: RHEA:22464
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050371
name: tyrosine phenol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + H2O = NH4 + phenol + pyruvate." [EC:4.1.99.2, RHEA:21704]
synonym: "beta-tyrosinase activity" RELATED [EC:4.1.99.2]
synonym: "L-tyrosine phenol-lyase (deaminating)" RELATED [EC:4.1.99.2]
synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.1.99.2]
xref: EC:4.1.99.2
xref: KEGG_REACTION:R00728
xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN
xref: RHEA:21704
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0050372
name: obsolete ubiquitin-calmodulin ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN]
comment: This term was obsoleted because it represents a specific substrate.
synonym: "calmodulin:ubiquitin ligase (AMP-forming)" RELATED [EC:6.3.2.21]
synonym: "ubiquitin-calmodulin synthetase activity" RELATED [EC:6.3.2.21]
synonym: "ubiquityl-calmodulin synthase activity" RELATED [EC:6.3.2.21]
synonym: "ubiquityl-calmodulin synthetase activity" RELATED [EC:6.3.2.21]
synonym: "uCaM-synthetase activity" RELATED [EC:6.3.2.21]
is_obsolete: true

[Term]
id: GO:0050373
name: UDP-arabinose 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose." [EC:5.1.3.5, RHEA:11320]
synonym: "UDP arabinose epimerase activity" RELATED [EC:5.1.3.5]
synonym: "UDP-D-xylose 4-epimerase activity" RELATED [EC:5.1.3.5]
synonym: "UDP-D-xylose-4-epimerase activity" EXACT []
synonym: "UDP-L-arabinose 4-epimerase activity" RELATED [EC:5.1.3.5]
synonym: "UDParabinose 4-epimerase activity" RELATED [EC:5.1.3.5]
synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" RELATED [EC:5.1.3.5]
synonym: "uridine diphosphoarabinose epimerase activity" RELATED [EC:5.1.3.5]
xref: EC:5.1.3.5
xref: KEGG_REACTION:R01473
xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN
xref: RHEA:11320
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050374
name: UDP-galacturonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + UDP-alpha-D-galacturonate = CO2 + UDP-L-arabinose." [EC:4.1.1.67, RHEA:19725]
synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" RELATED [EC:4.1.1.67]
synonym: "UDP-D-galacturonate carboxy-lyase activity" RELATED [EC:4.1.1.67]
synonym: "UDP-galacturonic acid decarboxylase activity" RELATED [EC:4.1.1.67]
synonym: "UDPgalacturonate decarboxylase activity" RELATED [EC:4.1.1.67]
synonym: "UDPGalUA carboxy lyase activity" RELATED [EC:4.1.1.67]
xref: EC:4.1.1.67
xref: KEGG_REACTION:R02636
xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN
xref: RHEA:19725
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050376
name: UDP-glucosamine 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN]
synonym: "UDP-glucosamine epimerase activity" EXACT []
synonym: "UDPglucosamine 4-epimerase activity" RELATED [EC:5.1.3.16]
xref: EC:5.1.3.16
xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN
xref: RHEA:23492
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050377
name: UDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose = H2O + UDP-4-dehydro-6-deoxy-D-glucose." [EC:4.2.1.76, RHEA:21500]
synonym: "UDP-D-glucose oxidoreductase activity" RELATED [EC:4.2.1.76]
synonym: "UDP-D-glucose-4,6-hydrolyase activity" RELATED [EC:4.2.1.76]
synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" RELATED [EC:4.2.1.76]
synonym: "UDP-glucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.76]
synonym: "UDPglucose 4,6-dehydratase activity" RELATED [EC:4.2.1.76]
synonym: "UDPglucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.76]
xref: EC:4.2.1.76
xref: KEGG_REACTION:R00293
xref: MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN
xref: RHEA:21500
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050378
name: UDP-glucuronate 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate." [EC:5.1.3.6, RHEA:11404]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
synonym: "UDP glucuronic epimerase activity" RELATED [EC:5.1.3.6]
synonym: "UDP-D-galacturonic acid 4-epimerase activity" RELATED [EC:5.1.3.6]
synonym: "UDP-galacturonate 4-epimerase activity" RELATED [EC:5.1.3.6]
synonym: "UDPglucuronate 4-epimerase activity" RELATED [EC:5.1.3.6]
synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6]
synonym: "uridine diphosphoglucuronate epimerase activity" RELATED [EC:5.1.3.6]
synonym: "uridine diphosphoglucuronic epimerase activity" RELATED [EC:5.1.3.6]
xref: EC:5.1.3.6
xref: KEGG_REACTION:R01385
xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN
xref: RHEA:11404
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050379
name: UDP-glucuronate 5'-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate." [GOC:curators]
synonym: "C-5-uronosyl epimerase activity" RELATED []
synonym: "UDP-glucuronate 5' epimerase activity" EXACT []
synonym: "UDP-glucuronic acid 5'-epimerase activity" RELATED []
synonym: "UDP-glucuronic acid epimerase activity" RELATED []
synonym: "UDPglucuronate 5'-epimerase activity" RELATED []
synonym: "uridine diphosphoglucuronate 5'-epimerase activity" RELATED []
xref: KEGG_REACTION:R01387
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050380
name: undecaprenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate." [PMID:18411271, RHEA:28094]
synonym: "C(55)-isoprenyl diphosphatase activity" RELATED [EC:3.6.1.27]
synonym: "C(55)-isoprenyl pyrophosphatase activity" RELATED [EC:3.6.1.27]
synonym: "C55-isoprenyl diphosphatase activity" RELATED [EC:3.6.1.27]
synonym: "C55-isoprenyl pyrophosphatase activity" RELATED [EC:3.6.1.27]
synonym: "isoprenyl pyrophosphatase activity" RELATED [EC:3.6.1.27]
synonym: "undecaprenyl-diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.27]
xref: EC:3.6.1.27
xref: KEGG_REACTION:R05627
xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN
xref: RHEA:28094
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050382
name: uracil-5-carboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + uracil 5-carboxylate = CO2 + uracil." [EC:4.1.1.66, RHEA:17685]
synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" RELATED [EC:4.1.1.66]
synonym: "uracil-5-carboxylate carboxy-lyase activity" RELATED [EC:4.1.1.66]
synonym: "uracil-5-carboxylic acid decarboxylase activity" RELATED [EC:4.1.1.66]
xref: EC:4.1.1.66
xref: KEGG_REACTION:R00973
xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN
xref: RHEA:17685
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050383
name: uracil dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [RHEA:22752]
xref: MetaCyc:URACIL-DEHYDROGENASE-RXN
xref: RHEA:22752
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0050384
name: urate-ribonucleotide phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H+ + urate." [EC:2.4.2.16, RHEA:13909]
synonym: "UAR phosphorylase activity" RELATED [EC:2.4.2.16]
synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.16]
synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" RELATED [EC:2.4.2.16]
xref: EC:2.4.2.16
xref: KEGG_REACTION:R02646
xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN
xref: RHEA:13909
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0050385
name: ureidoglycolate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, RHEA:11304]
comment: Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19 ; GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3 ; GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" RELATED [EC:4.3.2.3]
synonym: "(S)-ureidoglycolate urea-lyase activity" RELATED [EC:4.3.2.3]
synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3]
synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3]
synonym: "ureidoglycolate hydrolase activity" RELATED [PMID:24107613]
xref: EC:4.3.2.3
xref: KEGG_REACTION:R00776
xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN
xref: RHEA:11304
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0050386
name: ureidosuccinase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4." [EC:3.5.1.7, RHEA:14365]
synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" RELATED [EC:3.5.1.7]
xref: EC:3.5.1.7
xref: KEGG_REACTION:R00484
xref: MetaCyc:UREIDOSUCCINASE-RXN
xref: RHEA:14365
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050387
name: urethanase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + H+ + urethane = CO2 + ethanol + NH4." [EC:3.5.1.75, RHEA:21372]
synonym: "urethane amidohydrolase (decarboxylating)" RELATED [EC:3.5.1.75]
synonym: "urethane hydrolase activity" RELATED [EC:3.5.1.75]
xref: EC:3.5.1.75
xref: KEGG_REACTION:R02359
xref: MetaCyc:URETHANASE-RXN
xref: RHEA:21372
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050388
name: uronate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galacturonate + H2O + NAD+ = galactarate + 2 H+ + NADH." [EC:1.1.1.203, RHEA:22404]
synonym: "uronate: NAD-oxidoreductase activity" RELATED [EC:1.1.1.203]
synonym: "uronate:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.203]
synonym: "uronic acid dehydrogenase activity" RELATED [EC:1.1.1.203]
xref: EC:1.1.1.203
xref: KEGG_REACTION:R01981
xref: MetaCyc:URONATE-DEHYDROGENASE-RXN
xref: RHEA:22404
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050389
name: uronolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN]
synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" RELATED [EC:3.1.1.19]
synonym: "glucuronolactonase activity" RELATED [EC:3.1.1.19]
xref: EC:3.1.1.19
xref: MetaCyc:URONOLACTONASE-RXN
xref: RHEA:13337
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050390
name: valine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H+ = 2-methylpropanamine + CO2." [EC:4.1.1.14, RHEA:18989]
synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" RELATED [EC:4.1.1.14]
synonym: "L-valine carboxy-lyase activity" RELATED [EC:4.1.1.14]
synonym: "leucine decarboxylase activity" RELATED [EC:4.1.1.14]
xref: EC:4.1.1.14
xref: KEGG_REACTION:R01437
xref: MetaCyc:VALINE-DECARBOXYLASE-RXN
xref: RHEA:18989
xref: UM-BBD_reactionID:r1052
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050391
name: valine dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN]
synonym: "L-valine:NADP+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.8]
synonym: "valine dehydrogenase (NADP) activity" EXACT []
synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" RELATED [EC:1.4.1.8]
xref: EC:1.4.1.8
xref: MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:11156
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050392
name: vicianin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose." [EC:3.2.1.119, RHEA:14041]
synonym: "(R)-vicianin beta-D-glucohydrolase activity" RELATED [EC:3.2.1.119]
synonym: "vicianin b-glucosidase activity" EXACT []
synonym: "vicianin hydrolase activity" RELATED [EC:3.2.1.119]
xref: EC:3.2.1.119
xref: KEGG_REACTION:R03642
xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:14041
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050393
name: vinylacetyl-CoA delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA." [RHEA:10572]
synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3]
synonym: "vinylacetyl coenzyme A delta-isomerase activity" RELATED [EC:5.3.3.3]
synonym: "vinylacetyl coenzyme A isomerase activity" RELATED [EC:5.3.3.3]
synonym: "vinylacetyl-CoA D-isomerase activity" EXACT []
synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" RELATED [EC:5.3.3.3]
xref: EC:5.3.3.3
xref: KEGG_REACTION:R03031
xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN
xref: RHEA:10572
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050394
name: viomycin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN]
synonym: "ATP:viomycin O-phosphotransferase activity" RELATED [EC:2.7.1.103]
synonym: "capreomycin phosphotransferase activity" RELATED [EC:2.7.1.103]
synonym: "viomycin phosphotransferase activity" RELATED [EC:2.7.1.103]
xref: EC:2.7.1.103
xref: MetaCyc:VIOMYCIN-KINASE-RXN
xref: RHEA:20509
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050395
name: vitexin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose + vitexin = H+ + UDP + vitexin 2''-O-beta-D-glucoside." [EC:2.4.1.105, RHEA:21956]
synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.105]
synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.105]
synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" RELATED [EC:2.4.1.105]
synonym: "vitexin b-glucosyltransferase activity" EXACT []
xref: EC:2.4.1.105
xref: KEGG_REACTION:R03565
xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:21956
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050396
name: vomifoliol 4'-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + H+ + NADH." [EC:1.1.1.221, RHEA:22804]
synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" RELATED [EC:1.1.1.221]
xref: EC:1.1.1.221
xref: KEGG_REACTION:R04412
xref: MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN
xref: RHEA:22804
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050397
name: Watasenia-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "luciferase activity" BROAD [EC:1.13.12.8]
synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.8]
synonym: "Watasenia-type luciferase activity" RELATED [EC:1.13.12.8]
xref: EC:1.13.12.8
xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: RHEA:18057
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0050398
name: wax-ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN]
synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50]
synonym: "wax-ester acylhydrolase activity" RELATED [EC:3.1.1.50]
synonym: "WEH" RELATED [EC:3.1.1.50]
xref: EC:3.1.1.50
xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN
xref: RHEA:13577
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050399
name: xanthommatin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = H+ + NADH + xanthommatin." [EC:1.3.1.41, RHEA:13417]
synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.41]
xref: EC:1.3.1.41
xref: KEGG_REACTION:R03787
xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN
xref: RHEA:13417
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050400
name: xylitol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + xylitol = ADP + 2 H+ + xylitol 5-phosphate." [EC:2.7.1.122, RHEA:20209]
synonym: "ATP:xylitol 5-phosphotransferase activity" RELATED [EC:2.7.1.122]
synonym: "xylitol phosphotransferase activity" RELATED [EC:2.7.1.122]
xref: EC:2.7.1.122
xref: KEGG_REACTION:R02136
xref: MetaCyc:XYLITOL-KINASE-RXN
xref: RHEA:20209
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050401
name: xylonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O." [EC:4.2.1.82, RHEA:19157]
synonym: "D-xylo-aldonate dehydratase activity" RELATED [EC:4.2.1.82]
synonym: "D-xylonate dehydratase activity" RELATED [EC:4.2.1.82]
synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" RELATED [EC:4.2.1.82]
synonym: "D-xylonate hydro-lyase activity" RELATED [EC:4.2.1.82]
xref: EC:4.2.1.82
xref: KEGG_REACTION:R02429
xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN
xref: RHEA:19157
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050402
name: xylono-1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68]
synonym: "D-xylono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.68]
synonym: "xylono-g-lactonase activity" RELATED [EC:3.1.1.68]
synonym: "xylonolactonase activity" RELATED [EC:3.1.1.68]
xref: EC:3.1.1.68
xref: MetaCyc:RXN-19753
xref: RHEA:18341
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050403
name: trans-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H+ + UDP." [EC:2.4.1.203, RHEA:23224]
synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.203]
synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.203]
synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" RELATED [EC:2.4.1.203]
synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT []
synonym: "zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.203]
synonym: "zeatin O-glucosyltransferase activity" RELATED [EC:2.4.1.203]
xref: EC:2.4.1.203
xref: KEGG_REACTION:R02118
xref: MetaCyc:RXN-4723
xref: RHEA:23224
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050404
name: zeatin O-beta-D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H+ + UDP." [EC:2.4.2.40, RHEA:14721]
synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.40]
synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" RELATED [EC:2.4.2.40]
synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT []
synonym: "zeatin O-xylosyltransferase activity" RELATED [EC:2.4.2.40]
xref: EC:2.4.2.40
xref: KEGG_REACTION:R02119
xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN
xref: RHEA:14721
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0050405
name: obsolete [acetyl-CoA carboxylase] kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [GOC:curators]
comment: The reason for obsoletion is that this term was based on EC:2.7.11.27 which has been transferred to EC:2.7.11.31.
synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" RELATED [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" RELATED [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" RELATED [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase activity" RELATED [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-coenzyme A carboxylase kinase activity" RELATED [EC:2.7.11.27]
synonym: "ACK2" RELATED [EC:2.7.11.27]
synonym: "ACK3" RELATED [EC:2.7.11.27]
synonym: "AMPK" RELATED [EC:2.7.11.27]
synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" RELATED [EC:2.7.11.27]
synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27]
synonym: "STK5" RELATED [EC:2.7.11.27]
is_obsolete: true
replaced_by: GO:0047322

[Term]
id: GO:0050406
name: [acetyl-CoA carboxylase]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN]
synonym: "acetyl-CoA carboxylase-phosphatase activity" RELATED [EC:3.1.3.44]
synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.44]
xref: EC:3.1.3.44
xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN
xref: RHEA:17125
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0050407
name: [glycogen-synthase-D] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN]
synonym: "glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "glycogen synthase D phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "glycogen synthase phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "glycogen synthetase phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "glycogen-synthase-D phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "Mg2+ dependent glycogen synthase phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42]
synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" RELATED [EC:3.1.3.42]
synonym: "UDP-glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42]
synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" RELATED [EC:3.1.3.42]
synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42]
xref: EC:3.1.3.42
xref: MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0050408
name: [pyruvate kinase]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN]
synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.49]
synonym: "pyruvate kinase phosphatase activity" RELATED [EC:3.1.3.49]
synonym: "pyruvate kinase-phosphatase activity" RELATED [EC:3.1.3.49]
xref: EC:3.1.3.49
xref: MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0050409
name: indolylacetylinositol arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP." [EC:2.4.2.34, RHEA:19505]
synonym: "arabinosylindolylacetylinositol synthase activity" RELATED [EC:2.4.2.34]
synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" RELATED [EC:2.4.2.34]
synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" RELATED [EC:2.4.2.34]
xref: EC:2.4.2.34
xref: KEGG_REACTION:R04335
xref: MetaCyc:2.4.2.34-RXN
xref: RHEA:19505
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0052636 ! arabinosyltransferase activity

[Term]
id: GO:0050410
name: 3-oxolaurate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxododecanoate + H+ = 2-undecanone + CO2. Also decarboxylates other C14 to C16 oxo acids." [EC:4.1.1.56, RHEA:13385]
synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" RELATED [EC:4.1.1.56]
synonym: "3-oxododecanoate carboxy-lyase activity" RELATED [EC:4.1.1.56]
synonym: "beta-ketoacyl decarboxylase activity" RELATED [EC:4.1.1.56]
synonym: "beta-ketolaurate decarboxylase activity" RELATED [EC:4.1.1.56]
xref: EC:4.1.1.56
xref: KEGG_REACTION:R03747
xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN
xref: RHEA:13385
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050411
name: obsolete agaritine gamma-glutamyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [GOC:curators]
comment: This term was obsoleted because there is no enzyme known to catalyze this reaction.
synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" RELATED [EC:2.3.2.9]
synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" RELATED [EC:2.3.2.9]
synonym: "agaritine g-glutamyltransferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0050412
name: cinnamate beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP." [EC:2.4.1.177, RHEA:13437]
synonym: "cinnamate b-D-glucosyltransferase activity" EXACT []
synonym: "cinnamate glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.177]
synonym: "UDPG:t-cinnamate glucosyltransferase activity" RELATED [EC:2.4.1.177]
synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.177]
synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" RELATED [EC:2.4.1.177]
xref: EC:2.4.1.177
xref: KEGG_REACTION:R02256
xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:13437
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050413
name: D-alanine 2-hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, RHEA:10064]
synonym: "2-methylserine hydroxymethyltransferase activity" RELATED [EC:2.1.2.7]
synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" RELATED [EC:2.1.2.7]
synonym: "D-alanine hydroxymethyltransferase activity" EXACT []
xref: EC:2.1.2.7
xref: KEGG_REACTION:R01225
xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN
xref: RHEA:10064
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0050414
name: formimidoylaspartate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN]
synonym: "formiminoaspartate deiminase activity" EXACT []
synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" RELATED [EC:3.5.3.5]
xref: EC:3.5.3.5
xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN
xref: RHEA:13661
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050415
name: formimidoylglutamase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide." [EC:3.5.3.8, RHEA:22492]
synonym: "formiminoglutamase activity" EXACT []
synonym: "formiminoglutamate hydrolase activity" RELATED [EC:3.5.3.8]
synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" RELATED [EC:3.5.3.8]
synonym: "N-formimino-L-glutamate formiminohydrolase activity" RELATED [EC:3.5.3.8]
synonym: "N-formiminoglutamate hydrolase activity" RELATED [EC:3.5.3.8]
xref: EC:3.5.3.8
xref: KEGG_REACTION:R02285
xref: MetaCyc:FORMIMINOGLUTAMASE-RXN
xref: RHEA:22492
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050416
name: formimidoylglutamate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN]
synonym: "formiminoglutamate deiminase activity" EXACT []
synonym: "formiminoglutamic iminohydrolase activity" RELATED [EC:3.5.3.13]
synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" RELATED [EC:3.5.3.13]
xref: EC:3.5.3.13
xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN
xref: RHEA:22832
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050417
name: glutamin-(asparagin-)ase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate." [EC:3.5.1.38]
synonym: "glutaminase-(asparagin-)ase activity" EXACT []
synonym: "glutaminase-asparaginase activity" RELATED [EC:3.5.1.38]
synonym: "L-ASNase/L-GLNase activity" RELATED [EC:3.5.1.38]
synonym: "L-asparagine/L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.38]
synonym: "L-glutamine(L-asparagine) amidohydrolase activity" RELATED [EC:3.5.1.38]
xref: EC:3.5.1.38
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050418
name: hydroxylamine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN]
synonym: "ammonia:(acceptor) oxidoreductase activity" RELATED [EC:1.7.99.1]
synonym: "ammonia:acceptor oxidoreductase activity" RELATED [EC:1.7.99.1]
synonym: "hydroxylamine (acceptor) reductase activity" RELATED [EC:1.7.99.1]
xref: EC:1.7.99.1
xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN
xref: RHEA:22052
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0050419
name: hydroxymandelonitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [RHEA:15977]
synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" RELATED [EC:4.1.2.11]
synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" RELATED [EC:4.1.2.11]
synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11]
synonym: "sorghum hydroxynitrile lyase activity" RELATED [EC:4.1.2.11]
xref: EC:4.1.2.11
xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN
xref: RHEA:15977
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050420
name: maltose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN]
synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" RELATED [EC:2.4.1.139]
xref: EC:2.4.1.139
xref: MetaCyc:MALTOSE-SYNTHASE-RXN
xref: RHEA:22320
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050421
name: nitrite reductase (NO-forming) activity
namespace: molecular_function
alt_id: GO:0016666
def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN]
synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1]
synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome c-551:O2, NO2(+) oxidoreductase activity" RELATED [EC:1.7.2.1]
synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" RELATED [EC:1.7.2.1]
synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1]
synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1]
synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.7.2.1]
synonym: "nitrite reductase (cytochrome; NO-forming) activity" RELATED [EC:1.7.2.1]
synonym: "NO-forming nitrite reductase (cytochrome) activity" EXACT []
synonym: "NO-forming nitrite reductase activity" EXACT []
xref: EC:1.7.2.1
xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN
xref: RHEA:15233
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0050422
name: strictosidine beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone." [EC:3.2.1.105, RHEA:12917]
synonym: "strictosidine b-glucosidase activity" EXACT []
synonym: "strictosidine beta-D-glucohydrolase activity" RELATED [EC:3.2.1.105]
xref: EC:3.2.1.105
xref: KEGG_REACTION:R03820
xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN
xref: RHEA:12917
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050423
name: thiamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN]
synonym: "thiamin dehydrogenase activity" RELATED [EC:1.1.3.23]
synonym: "thiamin oxidase activity" EXACT []
synonym: "thiamin:oxygen 5-oxidoreductase activity" RELATED [EC:1.1.3.23]
synonym: "thiamine dehydrogenase activity" RELATED [EC:1.1.3.23]
synonym: "thiamine:oxygen 5-oxidoreductase activity" RELATED [EC:1.1.3.23]
xref: EC:1.1.3.23
xref: MetaCyc:THIAMIN-OXIDASE-RXN
xref: RHEA:21280
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050424
name: obsolete alanine carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "alanine carboxypeptidase activity" EXACT []
synonym: "N-benzoyl-L-alanine-amidohydrolase activity" RELATED [EC:3.4.17.6]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0050425
name: obsolete carboxypeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase B activity" EXACT []
synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2]
synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" RELATED [EC:3.4.17.2]
synonym: "protaminase activity" RELATED [EC:3.4.17.2]
synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2]
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0050426
name: obsolete peptidyl-glycinamidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "peptidyl-glycinamidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008242

[Term]
id: GO:0050427
name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732]
synonym: "3'-phosphoadenosine 5'-phosphosulfate metabolism" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolic process" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolism" EXACT []
synonym: "3'-phosphoadenylyl-sulfate metabolic process" EXACT []
synonym: "3'-phosphoadenylyl-sulfate metabolism" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolic process" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolism" EXACT []
synonym: "PAPS metabolic process" EXACT []
synonym: "PAPS metabolism" EXACT []
synonym: "phosphoadenosine phosphosulfate metabolic process" EXACT []
synonym: "phosphoadenosine phosphosulfate metabolism" EXACT []
xref: MetaCyc:PWY-5340
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0050428
name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732]
synonym: "3'-phosphoadenosine 5'-phosphosulfate anabolism" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate biosynthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate formation" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate synthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process" EXACT []
synonym: "3'-phosphoadenylyl-sulfate biosynthesis" EXACT []
synonym: "3'-phosphoadenylyl-sulfate biosynthetic process" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process" EXACT []
synonym: "PAPS biosynthesis" EXACT []
synonym: "PAPS biosynthetic process" EXACT []
synonym: "phosphoadenosine phosphosulfate biosynthesis" EXACT []
synonym: "phosphoadenosine phosphosulfate biosynthetic process" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0050427 ! 3'-phosphoadenosine 5'-phosphosulfate metabolic process

[Term]
id: GO:0050429
name: calcium-dependent phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+." [PMID:25769297, PMID:9426125]
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0050431
name: transforming growth factor beta binding
namespace: molecular_function
def: "Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732]
synonym: "TGF-beta binding" EXACT []
synonym: "TGFbeta binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0050432
name: catecholamine secretion
namespace: biological_process
def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef]
is_a: GO:0032940 ! secretion by cell
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0050433
name: regulation of catecholamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai]
is_a: GO:0051952 ! regulation of amine transport
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0050434
name: positive regulation of viral transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai]
synonym: "activation of viral transcription" NARROW []
synonym: "stimulation of viral transcription" NARROW []
synonym: "up regulation of viral transcription" EXACT []
synonym: "up-regulation of viral transcription" EXACT []
synonym: "upregulation of viral transcription" EXACT []
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:0048524 ! positive regulation of viral process
relationship: positively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0050435
name: amyloid-beta metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]
synonym: "amyloid-beta metabolism" EXACT []
synonym: "beta-amyloid metabolic process" EXACT []
synonym: "beta-amyloid metabolism" EXACT []
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0050436
name: microfibril binding
namespace: molecular_function
def: "Binding to a microfibril, any small fibril occurring in biological material." [GOC:ai]
comment: See also the cellular component term 'microfibril ; GO:0001527'.
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0050437
name: (-)-endo-fenchol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate." [EC:4.2.3.10, RHEA:20565]
synonym: "(-)-endo-fenchol cyclase activity" RELATED [EC:4.2.3.10]
synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" RELATED [EC:4.2.3.10]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10]
xref: EC:4.2.3.10
xref: KEGG_REACTION:R02004
xref: MetaCyc:4.2.3.10-RXN
xref: RHEA:20565
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050438
name: 2-ethylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H+." [RHEA:23040]
synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" RELATED [EC:2.3.3.6]
synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" RELATED [EC:2.3.3.6]
synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.6]
synonym: "propylmalate synthase activity" RELATED [EC:2.3.3.6]
synonym: "propylmalic synthase activity" RELATED [EC:2.3.3.6]
xref: EC:2.3.3.6
xref: KEGG_REACTION:R00998
xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN
xref: RHEA:23040
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050439
name: 2-hydroxy-3-oxoadipate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2." [EC:2.2.1.5, RHEA:14341]
synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" RELATED [EC:2.2.1.5]
synonym: "2-hydroxy-3-oxoadipate synthetase activity" RELATED [EC:2.2.1.5]
synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" RELATED [EC:2.2.1.5]
synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" RELATED [EC:2.2.1.5]
synonym: "oxoglutarate: glyoxylate carboligase activity" RELATED [EC:2.2.1.5]
synonym: "oxoglutarate:glyoxylate carboligase activity" RELATED [EC:2.2.1.5]
xref: EC:2.2.1.5
xref: KEGG_REACTION:R00474
xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN
xref: RHEA:14341
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0050440
name: 2-methylcitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H+." [RHEA:23780]
synonym: "2-methylcitrate oxaloacetate-lyase activity" RELATED [EC:2.3.3.5]
synonym: "MCS activity" RELATED [EC:2.3.3.5]
synonym: "methylcitrate synthase activity" RELATED [EC:2.3.3.5]
synonym: "methylcitrate synthetase activity" RELATED [EC:2.3.3.5]
synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" RELATED [EC:2.3.3.5]
xref: EC:2.3.3.5
xref: KEGG_REACTION:R00931
xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN
xref: RHEA:23780
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050441
name: 3-ethylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H+." [RHEA:10500]
synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" RELATED [EC:2.3.3.7]
synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" RELATED [EC:2.3.3.7]
synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" RELATED [EC:2.3.3.7]
xref: EC:2.3.3.7
xref: KEGG_REACTION:R01180
xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN
xref: RHEA:10500
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050442
name: 3-propylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+." [RHEA:14457]
synonym: "3-(n-propyl)-malate synthase activity" RELATED [EC:2.3.3.12]
synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" RELATED [EC:2.3.3.12]
synonym: "beta-n-propylmalate synthase activity" RELATED [EC:2.3.3.12]
synonym: "N-propylmalate synthase activity" RELATED [EC:2.3.3.12]
synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" RELATED [EC:2.3.3.12]
xref: EC:2.3.3.12
xref: KEGG_REACTION:R03040
xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN
xref: RHEA:14457
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050444
name: obsolete aquacobalamin reductase (NADPH) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [GOC:curators]
comment: This term was obsoleted because it is believed to be a spontaneous reaction.
is_obsolete: true

[Term]
id: GO:0050445
name: asparagusate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + H+ + NADH." [RHEA:14881]
synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" RELATED [EC:1.8.1.11]
synonym: "asparagusate dehydrogenase activity" RELATED [EC:1.8.1.11]
synonym: "asparagusate reductase (NADH) activity" EXACT []
synonym: "asparagusate reductase (NADH2)" RELATED [EC:1.8.1.11]
synonym: "asparagusic dehydrogenase activity" RELATED [EC:1.8.1.11]
synonym: "NADH2:asparagusate oxidoreductase activity" RELATED [EC:1.8.1.11]
synonym: "NADH:asparagusate oxidoreductase activity" RELATED [EC:1.8.1.11]
xref: EC:1.8.1.11
xref: KEGG_REACTION:R03761
xref: MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN
xref: RHEA:14881
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050446
name: azobenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP+ = 4-(dimethylamino)azobenzene + 2 H+ + 2 NADPH." [RHEA:16269]
synonym: "azo reductase activity" BROAD [EC:1.7.1.6]
synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6]
synonym: "azoreductase activity" BROAD [EC:1.7.1.6]
synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" RELATED [EC:1.7.1.6]
synonym: "dimethylaminobenzene reductase activity" RELATED [EC:1.7.1.6]
synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.6]
synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" RELATED [EC:1.7.1.6]
synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" RELATED [EC:1.7.1.6]
synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6]
synonym: "NADPH2-dependent azoreductase activity" RELATED [EC:1.7.1.6]
synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" RELATED [EC:1.7.1.6]
synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" RELATED [EC:1.7.1.6]
synonym: "NC-reductase activity" NARROW [EC:1.7.1.6]
synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6]
synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6]
synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" RELATED [EC:1.7.1.6]
synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "p-aminoazobenzene reductase activity" RELATED [EC:1.7.1.6]
synonym: "p-dimethylaminoazobenzene azoreductase activity" RELATED [EC:1.7.1.6]
xref: EC:1.7.1.6
xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN
xref: RHEA:16269
xref: UM-BBD_reactionID:r0808
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050447
name: zeatin 9-aminocarboxyethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+." [EC:2.5.1.50, RHEA:17333]
synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.50]
synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT []
synonym: "beta-(9-cytokinin)alanine synthase activity" RELATED [EC:2.5.1.50]
synonym: "lupinate synthetase activity" RELATED [EC:2.5.1.50]
synonym: "lupinic acid synthase activity" RELATED [EC:2.5.1.50]
synonym: "lupinic acid synthetase activity" RELATED [EC:2.5.1.50]
synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" RELATED [EC:2.5.1.50]
synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" RELATED [EC:2.5.1.50]
synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.50]
xref: EC:2.5.1.50
xref: KEGG_REACTION:R03133
xref: MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN
xref: RHEA:17333
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050448
name: beta-cyclopiazonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)." [RHEA:14525]
synonym: "b-cyclopiazonate dehydrogenase activity" EXACT []
synonym: "beta-cyclopiazonate oxidocyclase activity" RELATED [EC:1.21.99.1]
synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" RELATED [EC:1.21.99.1]
synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" RELATED [EC:1.21.99.1]
synonym: "beta-cyclopiazonic oxidocyclase activity" RELATED [EC:1.21.99.1]
xref: EC:1.21.99.1
xref: KEGG_REACTION:R04080
xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN
xref: RHEA:14525
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050449
name: casbene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, RHEA:14901]
synonym: "casbene synthetase activity" RELATED [EC:4.2.3.8]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" RELATED [EC:4.2.3.8]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" RELATED [EC:4.2.3.8]
xref: EC:4.2.3.8
xref: KEGG_REACTION:R02064
xref: MetaCyc:CASBENE-SYNTHASE-RXN
xref: RHEA:14901
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050450
name: citrate (Re)-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group." [PMID:17400742]
synonym: "(R)-citrate synthase activity" RELATED [EC:2.3.3.3]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3]
synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" RELATED [EC:2.3.3.3]
synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3]
synonym: "Re-citrate-synthase activity" RELATED [EC:2.3.3.3]
xref: EC:2.3.3.3
is_a: GO:0036440 ! citrate synthase activity

[Term]
id: GO:0050451
name: CoA-disulfide reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+." [RHEA:14705]
synonym: "CoA-disulfide reductase (NADH) activity" RELATED []
synonym: "CoA-disulfide reductase (NADP) activity" EXACT []
synonym: "CoA-disulfide reductase activity" BROAD []
synonym: "CoA-disulphide reductase activity" BROAD []
synonym: "CoADR activity" RELATED [EC:1.8.1.14]
synonym: "coenzyme A disulfide reductase activity" RELATED [EC:1.8.1.14]
synonym: "NADH:CoA-disulfide oxidoreductase activity" RELATED [EC:1.8.1.14]
xref: EC:1.8.1.14
xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN
xref: RHEA:14705
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050452
name: CoA-glutathione reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [RHEA:14617]
synonym: "CoA-glutathione reductase (NADP) activity" EXACT []
synonym: "CoA-glutathione reductase activity" BROAD []
synonym: "coenzyme A disulfide-glutathione reductase activity" BROAD [EC:1.8.1.10]
synonym: "coenzyme A glutathione disulfide reductase activity" BROAD [EC:1.8.1.10]
synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" EXACT [EC:1.8.1.10]
synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" EXACT [EC:1.8.1.10]
synonym: "NADPH:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10]
xref: EC:1.8.1.10
xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN
xref: RHEA:14617
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050453
name: obsolete cob(II)alamin reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 cob(I)alamin + H+ + NAD+ = 2 cob(II)alamin + NADH." [GOC:curators]
comment: This term was obsoleted because it is believed to be a spontaneous reaction.
synonym: "vitamin B12 reductase activity" EXACT []
synonym: "vitamin B12 reduction" RELATED []
is_obsolete: true

[Term]
id: GO:0050454
name: coenzyme F420 hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F420 + H(2) + H+ = reduced coenzyme F420." [EC:1.12.98.1, RHEA:23760]
synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" RELATED [EC:1.12.98.1]
synonym: "coenzyme F420-dependent hydrogenase activity" RELATED [EC:1.12.98.1]
synonym: "F420-reducing hydrogenase activity" RELATED [EC:1.12.98.1]
synonym: "hydrogen:coenzyme F420 oxidoreductase activity" RELATED [EC:1.12.98.1]
xref: EC:1.12.98.1
xref: KEGG_REACTION:R03025
xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN
xref: RHEA:23760
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0050455
name: columbamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O." [RHEA:23564]
synonym: "berberine synthase activity" RELATED [EC:1.21.3.2]
synonym: "columbamine:oxygen oxidoreductase (cyclizing)" RELATED [EC:1.21.3.2]
xref: EC:1.21.3.2
xref: KEGG_REACTION:R00044
xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN
xref: RHEA:23564
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0050456
name: cystine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + H+ + NADH." [EC:1.8.1.6, RHEA:20597]
synonym: "cystine reductase (NADH) activity" RELATED [EC:1.8.1.6]
synonym: "cystine reductase (NADH2)" RELATED [EC:1.8.1.6]
synonym: "L-cysteine:NAD+ oxidoreductase" RELATED [EC:1.8.1.6]
synonym: "NADH-dependent cystine reductase activity" RELATED [EC:1.8.1.6]
synonym: "NADH2:L-cystine oxidoreductase" RELATED [EC:1.8.1.6]
synonym: "NADH:L-cystine oxidoreductase activity" RELATED [EC:1.8.1.6]
xref: EC:1.8.1.6
xref: KEGG_REACTION:R00892
xref: MetaCyc:CYSTINE-REDUCTASE-NADH-RXN
xref: RHEA:20597
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050457
name: decylcitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H+." [RHEA:16605]
synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" RELATED [EC:2.3.3.2]
synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" RELATED [EC:2.3.3.2]
synonym: "2-decylcitrate synthase activity" RELATED [EC:2.3.3.2]
synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" RELATED [EC:2.3.3.2]
xref: EC:2.3.3.2
xref: KEGG_REACTION:R03735
xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN
xref: RHEA:16605
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050458
name: decylhomocitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + H2O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+." [RHEA:10364]
synonym: "2-decylhomocitrate synthase activity" RELATED [EC:2.3.3.4]
synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" RELATED [EC:2.3.3.4]
synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" RELATED [EC:2.3.3.4]
synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" RELATED [EC:2.3.3.4]
xref: EC:2.3.3.4
xref: KEGG_REACTION:R03859
xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN
xref: RHEA:10364
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050459
name: ethanolamine-phosphate phospho-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phosphoethanolamine = acetaldehyde + NH4 + phosphate." [EC:4.2.3.2, RHEA:17889]
synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2]
synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" RELATED [EC:4.2.3.2]
synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" RELATED [EC:4.2.3.2]
synonym: "O-phosphoethanolamine-phospholyase activity" RELATED [EC:4.2.3.2]
synonym: "O-phosphorylethanol-amine phospho-lyase activity" RELATED [EC:4.2.3.2]
xref: EC:4.2.3.2
xref: KEGG_REACTION:R00748
xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN
xref: Reactome:R-HSA-5696415 "PXLP-K278-ETNPPL tetramer hydrolyses PETA"
xref: RHEA:17889
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050460
name: hydroxylamine reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN]
synonym: "ammonium dehydrogenase activity" RELATED [EC:1.7.1.10]
synonym: "ammonium:NAD+ oxidoreductase activity" RELATED [EC:1.7.1.10]
synonym: "hydroxylamine reductase (NADH2)" RELATED [EC:1.7.1.10]
synonym: "N-hydroxy amine reductase activity" RELATED [EC:1.7.1.10]
synonym: "NADH-hydroxylamine reductase activity" RELATED [EC:1.7.1.10]
synonym: "NADH2:hydroxylamine oxidoreductase activity" RELATED [EC:1.7.1.10]
synonym: "NADH:hydroxylamine oxidoreductase activity" RELATED [EC:1.7.1.10]
xref: EC:1.7.1.10
xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN
xref: RHEA:20581
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050461
name: L-mimosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate." [RHEA:12693]
synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.52]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" RELATED [EC:2.5.1.52]
synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" RELATED [EC:2.5.1.52]
synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.52]
xref: EC:2.5.1.52
xref: KEGG_REACTION:R04091
xref: MetaCyc:RXN-7461
xref: RHEA:12693
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050462
name: N-acetylneuraminate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN]
synonym: "(NANA)condensing enzyme activity" RELATED [EC:2.5.1.56]
synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.56]
synonym: "N-acetylneuraminic acid synthase activity" RELATED [EC:2.5.1.56]
synonym: "NeuAc synthase activity" RELATED [EC:2.5.1.56]
synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" RELATED [EC:2.5.1.56]
xref: EC:2.5.1.56
xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN
xref: RHEA:19273
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050463
name: nitrate reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+." [EC:1.7.1.2]
synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "NAD(P)H bispecific nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "NAD(P)H2:nitrate oxidoreductase activity" RELATED [EC:1.7.1.2]
synonym: "NAD(P)H:nitrate oxidoreductase activity" RELATED [EC:1.7.1.2]
synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" RELATED [EC:1.7.1.2]
synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2]
synonym: "nitrate reductase NAD(P)H activity" RELATED [EC:1.7.1.2]
synonym: "nitrite:NAD(P)+ oxidoreductase activity" RELATED [EC:1.7.1.2]
xref: EC:1.7.1.2
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050464
name: nitrate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+." [RHEA:19061]
synonym: "assimilatory NADPH-nitrate reductase activity" RELATED [EC:1.7.1.3]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3]
synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" RELATED [EC:1.7.1.3]
synonym: "NADPH-nitrate reductase activity" RELATED [EC:1.7.1.3]
synonym: "NADPH:nitrate oxidoreductase activity" RELATED [EC:1.7.1.3]
synonym: "NADPH:nitrate reductase activity" RELATED [EC:1.7.1.3]
synonym: "nitrate reductase (NADPH(2)) activity" RELATED [EC:1.7.1.3]
synonym: "nitrate reductase (NADPH2)" RELATED [EC:1.7.1.3]
synonym: "nitrite:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.3]
synonym: "triphosphopyridine nucleotide-nitrate reductase activity" RELATED [EC:1.7.1.3]
xref: EC:1.7.1.3
xref: MetaCyc:NITRATE-REDUCTASE-NADPH-RXN
xref: RHEA:19061
is_a: GO:0050463 ! nitrate reductase [NAD(P)H] activity

[Term]
id: GO:0050465
name: nitroquinoline-N-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN]
synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.9]
synonym: "4-nitroquinoline 1-oxide reductase activity" RELATED [EC:1.7.1.9]
synonym: "4NQO reductase activity" RELATED [EC:1.7.1.9]
synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" RELATED [EC:1.7.1.9]
synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" RELATED [EC:1.7.1.9]
xref: EC:1.7.1.9
xref: MetaCyc:1.7.1.9-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050466
name: obsolete oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" EXACT []
is_obsolete: true
consider: GO:0046992

[Term]
id: GO:0050467
name: pentalenene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene." [EC:4.2.3.7, RHEA:18081]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" RELATED [EC:4.2.3.7]
synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" RELATED [EC:4.2.3.7]
synonym: "pentalenene synthetase activity" RELATED [EC:4.2.3.7]
xref: EC:4.2.3.7
xref: KEGG_REACTION:R02305
xref: MetaCyc:PENTALENENE-SYNTHASE-RXN
xref: RHEA:18081
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0050468
name: reticuline oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2 + H+. Also acts on related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines." [RHEA:19885]
synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" RELATED [EC:1.21.3.3]
synonym: "BBE" RELATED [EC:1.21.3.3]
synonym: "berberine bridge enzyme activity" RELATED [EC:1.21.3.3]
synonym: "berberine-bridge-forming enzyme activity" RELATED [EC:1.21.3.3]
synonym: "tetrahydroprotoberberine synthase activity" RELATED [EC:1.21.3.3]
xref: EC:1.21.3.3
xref: KEGG_REACTION:R03831
xref: MetaCyc:RETICULINE-OXIDASE-RXN
xref: RHEA:19885
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0050469
name: sabinene-hydrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H2O = diphosphate + sabinene hydrate." [EC:4.2.3.11, RHEA:19565]
synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" RELATED [EC:4.2.3.11]
synonym: "sabinene hydrate cyclase activity" RELATED [EC:4.2.3.11]
xref: EC:4.2.3.11
xref: KEGG_REACTION:R02006
xref: MetaCyc:4.2.3.11-RXN
xref: RHEA:19565
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050470
name: trimethylamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN]
synonym: "TMADh activity" RELATED [EC:1.5.8.2]
synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" RELATED [EC:1.5.8.2]
xref: EC:1.5.8.2
xref: MetaCyc:1.5.8.2-RXN
xref: RHEA:11864
xref: UM-BBD_enzymeID:r1378
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0050471
name: uracilylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [RHEA:11496]
synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.53]
synonym: "isowillardiine synthase activity" RELATED [EC:2.5.1.53]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" RELATED [EC:2.5.1.53]
synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" RELATED [EC:2.5.1.53]
synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.53]
synonym: "willardiine synthase activity" RELATED [EC:2.5.1.53]
xref: EC:2.5.1.53
xref: MetaCyc:RXN-7541
xref: RHEA:11496
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050472
name: zeatin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrozeatin + NADP+ = H+ + NADPH + zeatin." [EC:1.3.1.69, RHEA:12757]
synonym: "dihydrozeatin:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.69]
xref: EC:1.3.1.69
xref: KEGG_REACTION:R05702
xref: MetaCyc:ZEATIN-REDUCTASE-RXN
xref: RHEA:12757
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050473
name: arachidonate 15-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33]
synonym: "15-lipoxygenase activity" RELATED [EC:1.13.11.33]
synonym: "arachidonate omega(6) lipoxygenase activity" RELATED [EC:1.13.11.33]
synonym: "arachidonate omega6 lipoxygenase activity" RELATED [EC:1.13.11.33]
synonym: "arachidonate:oxygen 15-oxidoreductase activity" RELATED [EC:1.13.11.33]
synonym: "linoleic acid omega6-lipoxygenase activity" RELATED [EC:1.13.11.33]
synonym: "omega6 lipoxygenase activity" RELATED [EC:1.13.11.33]
xref: EC:1.13.11.33
xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN
xref: Reactome:R-HSA-2162002 "Arachidonate is oxidised to 15S-HpETE by ALOX15/15B"
xref: Reactome:R-HSA-9018907 "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3"
xref: Reactome:R-HSA-9020262 "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA"
xref: Reactome:R-HSA-9020275 "ALOX15 oxidises DHA to 17(S)-Hp-DHA"
xref: Reactome:R-HSA-9020610 "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3"
xref: Reactome:R-HSA-9024872 "ALOX15 oxidises 17(S)-Hp-DHA to PDX"
xref: Reactome:R-HSA-9024881 "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA"
xref: Reactome:R-HSA-9025152 "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6"
xref: Reactome:R-HSA-9026003 "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3"
xref: RHEA:16869
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050474
name: (S)-norcoclaurine synthase activity
namespace: molecular_function
alt_id: GO:0050475
def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [RHEA:16173]
synonym: "(S)-norlaudanosoline synthase activity" RELATED [EC:3.5.99.14]
synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" RELATED [EC:3.5.99.14]
synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:3.5.99.14]
xref: EC:3.5.99.14
xref: MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN
xref: RHEA:16173
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050476
name: acetylenedicarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78]
synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" RELATED [EC:4.1.1.78]
synonym: "acetylenedicarboxylate carboxy-lyase activity" RELATED [EC:4.1.1.78]
synonym: "acetylenedicarboxylate hydrase activity" RELATED [EC:4.1.1.78]
synonym: "acetylenedicarboxylate hydratase activity" RELATED [EC:4.1.1.78]
xref: EC:4.1.1.78
xref: MetaCyc:4.1.1.78-RXN
xref: RHEA:17733
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050477
name: acyl-lysine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17]
synonym: "6-N-acyl-L-lysine amidohydrolase activity" RELATED [EC:3.5.1.17]
synonym: "epsilon-lysine acylase activity" RELATED [EC:3.5.1.17]
synonym: "N6-acyl-L-lysine amidohydrolase activity" RELATED [EC:3.5.1.17]
xref: EC:3.5.1.17
xref: MetaCyc:ACYL-LYSINE-DEACYLASE-RXN
xref: RHEA:24548
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050478
name: obsolete anthranilate 3-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + anthranilate + O2 = 3-hydroxyanthranilate + 7,8-dihydrobiopterin + H2O." [GOC:curators]
comment: This term is slated for obsoletion; According to RHEA the activity does not exist.
synonym: "anthranilate 3-hydroxylase activity" EXACT []
synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" RELATED []
synonym: "anthranilic acid hydroxylase activity" BROAD []
is_obsolete: true

[Term]
id: GO:0050479
name: glyceryl-ether monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN]
synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" RELATED [EC:1.14.16.5]
synonym: "alkylglycerol monooxygenase activity" RELATED [EC:1.14.16.5]
synonym: "glyceryl ether oxygenase activity" RELATED [EC:1.14.16.5]
synonym: "glyceryl etherase activity" RELATED [EC:1.14.16.5]
synonym: "glyceryl-ether cleaving enzyme activity" RELATED [EC:1.14.16.5]
synonym: "O-alkylglycerol monooxygenase activity" RELATED [EC:1.14.16.5]
xref: EC:1.14.16.5
xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-5696119 "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol"
xref: RHEA:36255
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050480
name: imidazolonepropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+." [EC:3.5.2.7, RHEA:23660]
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" RELATED [EC:3.5.2.7]
synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" RELATED [EC:3.5.2.7]
synonym: "imidazolone propionic acid hydrolase activity" RELATED [EC:3.5.2.7]
synonym: "imidazolone-5-propionate hydrolase activity" RELATED [EC:3.5.2.7]
xref: EC:3.5.2.7
xref: KEGG_REACTION:R02288
xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN
xref: RHEA:23660
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050481
name: mandelate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H2O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, RHEA:21716]
synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.16.6]
synonym: "L-mandelate 4-hydroxylase activity" EXACT []
synonym: "mandelic acid 4-hydroxylase activity" RELATED [EC:1.14.16.6]
xref: EC:1.14.16.6
xref: KEGG_REACTION:R03794
xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN
xref: RHEA:21716
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050482
name: arachidonate secretion
namespace: biological_process
def: "The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]
comment: This term should be used to annotate release of arachidonic acid from the cell. For the hydrolytic release of arachidonic acid from a phospholipid, consider instead annotating to 'phospholipase A2 activity ; GO:0004623'.
synonym: "arachidonic acid secretion" EXACT []
is_a: GO:0032309 ! icosanoid secretion
is_a: GO:1903963 ! arachidonate transport

[Term]
id: GO:0050483
name: IMP 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai]
synonym: "IMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED []
xref: MetaCyc:RXN-7607
xref: RHEA:27718
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0050484
name: GMP 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai]
synonym: "GMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED []
xref: MetaCyc:RXN-7609
xref: RHEA:27714
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0050485
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [EC:1.21.4.-]
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT []
xref: EC:1.21.4.-
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050486
name: intramolecular hydroxytransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah]
synonym: "intramolecular transferase activity, transferring hydroxy groups" EXACT []
xref: EC:5.4.4.-
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050487
name: sulfoacetaldehyde acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + H+ + sulfite = phosphate + sulfoacetaldehyde." [RHEA:24204]
comment: The reaction occurs in the reverse direction.
synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" RELATED [EC:2.3.3.15]
synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT []
xref: EC:2.3.3.15
xref: KEGG_REACTION:R05651
xref: MetaCyc:RXN-2364
xref: RHEA:24204
is_a: GO:0046912 ! acyltransferase activity, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050488
name: ecdysteroid UDP-glucosyltransferase activity
namespace: molecular_function
alt_id: GO:0050489
def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai, PMID:10073711]
synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED []
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050490
name: 1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN]
synonym: "1,4-lactone hydroxyacylhydrolase activity" RELATED [EC:3.1.1.25]
synonym: "gamma-lactonase activity" RELATED [EC:3.1.1.25]
xref: EC:3.1.1.25
xref: MetaCyc:14-LACTONASE-RXN
xref: RHEA:12745
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050491
name: sulcatone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + sulcatol = H+ + NADH + sulcatone." [EC:1.1.1.260, RHEA:24484]
synonym: "sulcatol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.260]
xref: EC:1.1.1.260
xref: KEGG_REACTION:R05678
xref: MetaCyc:1.1.1.260-RXN
xref: RHEA:24484
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050492
name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261]
synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.261]
xref: EC:1.1.1.261
xref: MetaCyc:1.1.1.261-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050493
name: obsolete GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0006506

[Term]
id: GO:0050494
name: obsolete GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165]
comment: This term was obsoleted because it represents a molecular function.
synonym: "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
is_obsolete: true

[Term]
id: GO:0050495
name: obsolete peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine" EXACT []
is_obsolete: true

[Term]
id: GO:0050496
name: obsolete peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine" EXACT []
is_obsolete: true

[Term]
id: GO:0050497
name: alkylthioltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [EC:2.8.4.-, GOC:ai]
synonym: "transferase activity, transferring alkylthio groups" EXACT []
xref: EC:2.8.4.-
is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups

[Term]
id: GO:0050498
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [EC:1.14.20.-]
xref: EC:1.14.20.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050499
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah]
xref: EC:1.20.1.-
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050500
name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN]
synonym: "beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT []
synonym: "beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" RELATED [EC:2.4.1.211]
synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" RELATED [EC:2.4.1.211]
xref: EC:2.4.1.211
xref: MetaCyc:2.4.1.211-RXN
xref: RHEA:20285
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050501
name: hyaluronan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN]
synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" RELATED [EC:2.4.1.212]
synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" RELATED [EC:2.4.1.212]
synonym: "HAS activity" BROAD [EC:2.4.1.212]
synonym: "seHAS" RELATED [EC:2.4.1.212]
synonym: "spHAS" RELATED [EC:2.4.1.212]
xref: EC:2.4.1.212
xref: MetaCyc:2.4.1.212-RXN
xref: Reactome:R-HSA-2160851 "HAS1,2,3 mediate the polymerization of HA"
xref: RHEA:12528
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050502
name: cis-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H+ + UDP." [EC:2.4.1.215, RHEA:20681]
synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.215]
synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.215]
xref: EC:2.4.1.215
xref: KEGG_REACTION:R07260
xref: MetaCyc:RXN-4735
xref: RHEA:20681
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050503
name: trehalose 6-phosphate phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN]
synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.216]
xref: EC:2.4.1.216
xref: MetaCyc:2.4.1.216-RXN
xref: RHEA:20864
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0050504
name: mannosyl-3-phosphoglycerate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H+." [EC:2.4.1.217, RHEA:13537]
synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.217]
synonym: "MPG synthase activity" RELATED [EC:2.4.1.217]
xref: EC:2.4.1.217
xref: KEGG_REACTION:R05768
xref: MetaCyc:2.4.1.217-RXN
xref: RHEA:13537
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050505
name: hydroquinone glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = H+ + hydroquinone O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, RHEA:12560]
synonym: "arbutin synthase activity" RELATED [EC:2.4.1.218]
synonym: "hydroquinone:O-glucosyltransferase activity" RELATED [EC:2.4.1.218]
synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.218]
synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.218]
xref: EC:2.4.1.218
xref: KEGG_REACTION:R05769
xref: MetaCyc:2.4.1.218-RXN
xref: RHEA:12560
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050506
name: vomilenine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose + vomilenine = H+ + raucaffricine + UDP." [EC:2.4.1.219, RHEA:19385]
synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.219]
synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.219]
synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.219]
synonym: "vomilenine-glucosyltransferase activity" RELATED [EC:2.4.1.219]
xref: EC:2.4.1.219
xref: KEGG_REACTION:R05882
xref: MetaCyc:2.4.1.219-RXN
xref: RHEA:19385
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050507
name: indoxyl-UDPG glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = H+ + indican + UDP." [EC:2.4.1.220, RHEA:12004]
synonym: "indoxyl-UDPG-glucosyltransferase activity" RELATED [EC:2.4.1.220]
synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.220]
xref: EC:2.4.1.220
xref: KEGG_REACTION:R06048
xref: MetaCyc:2.4.1.220-RXN
xref: RHEA:12004
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050508
name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H+ + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN, RHEA:16213]
synonym: "alpha-N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.224]
synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.224]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.224]
xref: EC:2.4.1.224
xref: MetaCyc:2.4.1.224-RXN
xref: Reactome:R-HSA-2022851 "EXT1:EXT2 transfer GlcNAc to the heparan chain"
xref: Reactome:R-HSA-2022919 "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue"
xref: Reactome:R-HSA-3656254 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain"
xref: Reactome:R-HSA-3656261 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain"
xref: Reactome:R-HSA-9036283 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue"
xref: Reactome:R-HSA-9036290 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan"
xref: RHEA:16213
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0050509
name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H+ + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN, RHEA:20908]
synonym: "heparan glucuronyltransferase II activity" RELATED [EC:2.4.1.225]
synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT []
synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" RELATED [EC:2.4.1.225]
synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" RELATED [EC:2.4.1.225]
xref: EC:2.4.1.225
xref: MetaCyc:2.4.1.225-RXN
xref: Reactome:R-HSA-2022856 "EXT1:EXT2 transfers GlcNAc to heparan"
xref: Reactome:R-HSA-2076392 "EXT1:EXT2 transfers GlcA to heparan"
xref: Reactome:R-HSA-3656257 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan"
xref: Reactome:R-HSA-3656267 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan"
xref: Reactome:R-HSA-9036285 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan"
xref: Reactome:R-HSA-9036289 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan"
xref: RHEA:20908
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050510
name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226]
synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" RELATED [EC:2.4.1.226]
synonym: "chondroitin glucuronyltransferase II activity" RELATED [EC:2.4.1.226]
synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT []
xref: EC:2.4.1.226
xref: MetaCyc:RXN-16324
xref: Reactome:R-HSA-1971491 "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin"
xref: Reactome:R-HSA-3595178 "Defective CHSY1 does not transfer GlcA to chondroitin"
xref: Reactome:R-HSA-9632034 "CHSY1 transfers GlcA to chondroitin"
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050511
name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamm-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H+ + UDP." [RHEA:23192]
synonym: "MurG transferase activity" RELATED [EC:2.4.1.227]
synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" RELATED [EC:2.4.1.227]
synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" RELATED [EC:2.4.1.227]
synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" RELATED [EC:2.4.1.227]
synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT []
xref: MetaCyc:RXN-8976
xref: RHEA:23192
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0050512
name: lactosylceramide 4-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN]
synonym: "Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.228]
synonym: "Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.228]
synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228]
synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228]
synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228]
synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.228]
xref: EC:2.4.1.228
xref: MetaCyc:2.4.1.228-RXN
xref: Reactome:R-HSA-9846477 "A4GALT transfers galactose to LacCer"
xref: RHEA:11924
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0050513
name: glycoprotein 2-beta-D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H+ + UDP." [EC:2.4.2.38, RHEA:10612]
synonym: "1,2-beta-xylosyltransferase activity" RELATED [EC:2.4.2.38]
synonym: "beta-1,2-xylosyltransferase activity" RELATED [EC:2.4.2.38]
synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT []
xref: EC:2.4.2.38
xref: KEGG_REACTION:R06016
xref: MetaCyc:2.4.2.38-RXN
xref: RHEA:10612
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0050514
name: homospermidine synthase (spermidine-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN]
synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" RELATED [EC:2.5.1.45]
xref: EC:2.5.1.45
xref: MetaCyc:2.5.1.45-RXN
xref: RHEA:11236
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050515
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
namespace: molecular_function
alt_id: GO:0008698
def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+." [EC:2.7.1.148, RHEA:18437]
synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" RELATED [EC:2.7.1.148]
synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT []
synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" RELATED [EC:2.7.1.148]
synonym: "CDP-ME kinase activity" RELATED [EC:2.7.1.148]
synonym: "CMK activity" RELATED [EC:2.7.1.148]
xref: EC:2.7.1.148
xref: KEGG_REACTION:R05634
xref: MetaCyc:2.7.1.148-RXN
xref: RHEA:18437
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050516
name: obsolete inositol polyphosphate multikinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:curators]
comment: This term was made obsolete because this activity is currently defined as catalyzing two sequential reactions based on a gene product. However, "inositol polyphosphate multikinase activity" in some organisms can catalyze additional reactions. In addition, the reactions listed in the definition can be catalyzed independently by other gene products.
synonym: "inositol polyphosphate multikinase activity" EXACT []
synonym: "inositol-polyphosphate multikinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0050517
name: obsolete inositol hexakisphosphate kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [GOC:curators]
comment: Note that this was EC:2.7.1.152. This term was made obsolete because this activity is currently defined as catalyzing two reactions based on a gene product. The reactions listed in the definition can be catalyzed independently by other gene products.
synonym: "inositol hexakisphosphate kinase activity" EXACT []
synonym: "inositol-hexakisphosphate kinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0050518
name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
namespace: molecular_function
alt_id: GO:0008699
def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate." [EC:2.7.7.60, RHEA:13429]
synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" RELATED [EC:2.7.7.60]
synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT []
synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT []
synonym: "MCT activity" RELATED [EC:2.7.7.60]
synonym: "MEP cytidylyltransferase activity" EXACT []
xref: EC:2.7.7.60
xref: KEGG_REACTION:R05633
xref: MetaCyc:2.7.7.60-RXN
xref: RHEA:13429
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0050519
name: holo-citrate lyase synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN]
synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" RELATED [EC:2.7.7.61]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" RELATED [EC:2.7.7.61]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" RELATED [EC:2.7.7.61]
synonym: "CitX" RELATED [EC:2.7.7.61]
synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61]
xref: EC:2.7.7.61
xref: MetaCyc:2.7.7.61-RXN
xref: RHEA:16333
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0050520
name: phosphatidylcholine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+." [EC:2.7.8.24, RHEA:14597]
synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" RELATED [EC:2.7.8.24]
synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" RELATED [EC:2.7.8.24]
synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" RELATED [EC:2.7.8.24]
synonym: "PC synthase activity" RELATED [EC:2.7.8.24]
xref: EC:2.7.8.24
xref: KEGG_REACTION:R05794
xref: MetaCyc:2.7.8.24-RXN
xref: RHEA:14597
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0050521
name: alpha-glucan, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H+ + n phosphate." [RHEA:11668]
synonym: "a-glucan, water dikinase activity" EXACT []
synonym: "alpha-glucan,water dikinase activity" RELATED [EC:2.7.9.4]
synonym: "ATP:alpha-glucan, water phosphotransferase activity" RELATED [EC:2.7.9.4]
synonym: "GWD" RELATED [EC:2.7.9.4]
synonym: "starch-related R1 protein activity" RELATED [EC:2.7.9.4]
xref: EC:2.7.9.4
xref: MetaCyc:2.7.9.4-RXN
xref: RHEA:11668
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0050522
name: obsolete oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0050523
name: obsolete oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" EXACT []
is_obsolete: true
consider: GO:0030613

[Term]
id: GO:0050524
name: coenzyme-B sulfoethylthiotransferase activity
namespace: molecular_function
alt_id: GO:0018552
def: "Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB." [EC:2.8.4.1, RHEA:12532]
synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" RELATED [EC:2.8.4.1]
synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT []
synonym: "methyl coenzyme M reductase activity" RELATED [EC:2.8.4.1]
synonym: "methyl-coenzyme-M reductase activity" EXACT []
synonym: "methyl-CoM reductase activity" RELATED [EC:2.8.4.1]
xref: EC:2.8.4.1
xref: KEGG_REACTION:R04541
xref: MetaCyc:METHYL-COM-HTP-RXN
xref: RHEA:12532
xref: UM-BBD_reactionID:r0356
is_a: GO:0050497 ! alkylthioltransferase activity

[Term]
id: GO:0050525
name: cutinase activity
namespace: molecular_function
def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN]
synonym: "cutin hydrolase activity" RELATED [EC:3.1.1.74]
xref: EC:3.1.1.74
xref: MetaCyc:3.1.1.74-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050526
name: poly(3-hydroxybutyrate) depolymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN]
synonym: "PHB depolymerase activity" RELATED [EC:3.1.1.75]
synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75]
synonym: "poly(3HB) depolymerase activity" RELATED [EC:3.1.1.75]
synonym: "poly(HA(SCL)) depolymerase activity" RELATED [EC:3.1.1.75]
synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75]
synonym: "poly(HASCL) depolymerase activity" RELATED [EC:3.1.1.75]
synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" RELATED [EC:3.1.1.75]
synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75]
xref: EC:3.1.1.75
xref: MetaCyc:3.1.1.75-RXN
xref: RHEA:11248
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050527
name: poly(3-hydroxyoctanoate) depolymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN]
synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "PHO depolymerase activity" RELATED [EC:3.1.1.76]
synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" RELATED [EC:3.1.1.76]
synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "poly(3HO) depolymerase activity" RELATED [EC:3.1.1.76]
synonym: "poly(HA(MCL)) depolymerase activity" RELATED [EC:3.1.1.76]
synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "poly(HAMCL) depolymerase activity" RELATED [EC:3.1.1.76]
synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" RELATED [EC:3.1.1.76]
synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76]
synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" RELATED [EC:3.1.1.76]
xref: EC:3.1.1.76
xref: MetaCyc:3.1.1.76-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050528
name: acyloxyacyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN]
xref: EC:3.1.1.77
xref: MetaCyc:3.1.1.77-RXN
xref: RHEA:12032
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050529
name: polyneuridine-aldehyde esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol." [EC:3.1.1.78, RHEA:17501]
synonym: "PNAE activity" RELATED [EC:3.1.1.78]
synonym: "polyneuridine aldehyde esterase activity" RELATED [EC:3.1.1.78]
synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" RELATED [EC:3.1.1.78]
xref: EC:3.1.1.78
xref: KEGG_REACTION:R05825
xref: MetaCyc:3.1.1.78-RXN
xref: RHEA:17501
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050530
name: glucosylglycerol 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, RHEA:22652]
synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.69]
synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69]
synonym: "StpA" RELATED [EC:3.1.3.69]
xref: EC:3.1.3.69
xref: KEGG_REACTION:R05791
xref: MetaCyc:3.1.3.69-RXN
xref: RHEA:22652
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050531
name: mannosyl-3-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, RHEA:19309]
synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" RELATED [EC:3.1.3.70]
xref: EC:3.1.3.70
xref: KEGG_REACTION:R05790
xref: MetaCyc:3.1.3.70-RXN
xref: RHEA:19309
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050532
name: 2-phosphosulfolactate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate." [EC:3.1.3.71, RHEA:23416]
synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" RELATED [EC:3.1.3.71]
synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" RELATED [EC:3.1.3.71]
synonym: "2-phosphosulpholactate phosphatase activity" EXACT []
synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71]
xref: EC:3.1.3.71
xref: KEGG_REACTION:R05789
xref: MetaCyc:R229-RXN
xref: RHEA:23416
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050533
name: 5-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate." [RHEA:13001]
synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" RELATED [EC:3.1.3.72]
xref: EC:3.1.3.72
xref: MetaCyc:3.1.3.72-RXN
xref: RHEA:13001
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050534
name: 3-deoxyoctulosonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144]
synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" RELATED [EC:3.2.1.144]
synonym: "alpha-Kdo-ase activity" RELATED [EC:3.2.1.144]
xref: EC:3.2.1.144
xref: MetaCyc:RXN-12002
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050535
name: beta-primeverosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [RHEA:24480]
synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" RELATED [EC:3.2.1.149]
synonym: "b-primeverosidase activity" EXACT []
xref: EC:3.2.1.149
xref: MetaCyc:3.2.1.149-RXN
xref: RHEA:24480
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050536
name: (S)-N-acetyl-1-phenylethylamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylphenylethylamine + H2O = acetate + phenylethylamine." [EC:3.5.1.85, RHEA:23952]
synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" RELATED [EC:3.5.1.85]
synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" RELATED [EC:3.5.1.85]
xref: EC:3.5.1.85
xref: KEGG_REACTION:R07301
xref: MetaCyc:3.5.1.85-RXN
xref: RHEA:23952
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050537
name: mandelamide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH4." [EC:3.5.1.86, RHEA:22876]
synonym: "mandelamide hydrolase activity" RELATED [EC:3.5.1.86]
synonym: "Pseudomonas mandelamide hydrolase activity" RELATED [EC:3.5.1.86]
xref: EC:3.5.1.86
xref: KEGG_REACTION:R05783
xref: MetaCyc:3.5.1.86-RXN
xref: RHEA:22876
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050538
name: N-carbamoyl-L-amino-acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN]
synonym: "L-carbamoylase activity" RELATED [EC:3.5.1.87]
synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" RELATED [EC:3.5.1.87]
xref: EC:3.5.1.87
xref: MetaCyc:3.5.1.87-RXN
xref: RHEA:17581
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050539
name: maleimide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + maleimide = H+ + maleamate." [EC:3.5.2.16, RHEA:24476]
synonym: "cyclic imide hydrolase activity" RELATED [EC:3.5.2.16]
synonym: "cyclic-imide amidohydrolase (decyclicizing)" RELATED [EC:3.5.2.16]
synonym: "cyclic-imide amidohydrolase (decyclizing)" RELATED [EC:3.5.2.16]
synonym: "imidase activity" BROAD [EC:3.5.2.16]
xref: EC:3.5.2.16
xref: KEGG_REACTION:R05781
xref: MetaCyc:3.5.2.16-RXN
xref: RHEA:24476
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050540
name: 2-aminomuconate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminomuconate + H2O + H+ = (Z)-5-oxohex-2-enedioate + NH4." [EC:3.5.99.5, RHEA:20996]
synonym: "2-aminomuconate aminohydrolase activity" RELATED [EC:3.5.99.5]
xref: EC:3.5.99.5
xref: KEGG_REACTION:R03887
xref: MetaCyc:3.5.99.5-RXN
xref: RHEA:20996
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050541
name: beta,beta-carotene-9',10'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918]
synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT []
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050542
name: icosanoid binding
namespace: molecular_function
def: "Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732]
synonym: "eicosanoid binding" EXACT []
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0050543
name: icosatetraenoic acid binding
namespace: molecular_function
def: "Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732]
synonym: "eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0050544
name: arachidonate binding
namespace: molecular_function
def: "Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai]
synonym: "arachidonic acid binding" EXACT []
is_a: GO:0050542 ! icosanoid binding
is_a: GO:0050543 ! icosatetraenoic acid binding

[Term]
id: GO:0050545
name: sulfopyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde." [EC:4.1.1.79, RHEA:20948]
synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" RELATED [EC:4.1.1.79]
synonym: "sulfopyruvate carboxy-lyase activity" RELATED [EC:4.1.1.79]
synonym: "sulphopyruvate decarboxylase activity" EXACT []
xref: EC:4.1.1.79
xref: KEGG_REACTION:R05774
xref: MetaCyc:R231-RXN
xref: RHEA:20948
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050546
name: 4-hydroxyphenylpyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H+ = (4-hydroxyphenyl)acetaldehyde + CO2." [EC:4.1.1.80, RHEA:18697]
synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" RELATED [EC:4.1.1.80]
synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" RELATED [EC:4.1.1.80]
xref: EC:4.1.1.80
xref: KEGG_REACTION:R03341
xref: MetaCyc:4.1.1.80-RXN
xref: RHEA:18697
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050547
name: feruloyl-CoA hydratase/lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin." [RHEA:62412]
synonym: "enoyl-CoA hydratase/aldolase activity" RELATED [EC:4.1.2.61]
synonym: "hydroxycinnamoyl-CoA hydratase lyase activity" RELATED [EC:4.1.2.61]
synonym: "vanillin synthase activity" RELATED []
xref: EC:4.1.2.61
xref: KEGG_REACTION:R12566
xref: MetaCyc:RXN-21004
xref: RHEA:62412
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050548
name: obsolete trans-feruloyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [GOC:curators]
comment: The reason for obsoletion is that this term was based on EC:4.2.1.101 which has been transferred to EC:4.1.2.61.
synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" RELATED [EC:4.2.1.101]
synonym: "trans-feruloyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.101]
is_obsolete: true
replaced_by: GO:0050547

[Term]
id: GO:0050549
name: cyclohexyl-isocyanide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclohexylformamide + H+ = cyclohexyl isocyanide + H2O." [EC:4.2.1.103, RHEA:18197]
synonym: "isonitrile hydratase activity" RELATED [EC:4.2.1.103]
synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" RELATED [EC:4.2.1.103]
synonym: "N-cyclohexylformamide hydro-lyase activity" RELATED [EC:4.2.1.103]
xref: EC:4.2.1.103
xref: KEGG_REACTION:R05771
xref: MetaCyc:4.2.1.103-RXN
xref: RHEA:18197
xref: UM-BBD_reactionID:r1029
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050550
name: pinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. This reaction can produce (1R,5R)-alpha-pinene, (1S,5S)-alpha-pinene, (1R,5R)-beta-pinene and (1S,5S)-beta-pinene." [PMID:21385377, PMID:23679205]
synonym: "(-)-(1S,5S)-pinene synthase activity" NARROW [EC:4.2.3.120]
synonym: "alpha-pinene synthase activity" NARROW [EC:4.2.3.119]
synonym: "beta-geraniolene synthase activity" RELATED [EC:4.2.3.120]
synonym: "beta-pinene synthase activity" NARROW [EC:4.2.3.120]
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050551
name: myrcene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene." [EC:4.2.3.15, RHEA:16965]
synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT []
xref: EC:4.2.3.15
xref: KEGG_REACTION:R02009
xref: MetaCyc:RXN-5110
xref: RHEA:16965
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050552
name: (4S)-limonene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN]
synonym: "(-)-(4S)-limonene synthase activity" EXACT []
synonym: "4S-(-)-limonene synthase activity" RELATED [EC:4.2.3.16]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16]
synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" RELATED [EC:4.2.3.16]
synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16]
xref: EC:4.2.3.16
xref: MetaCyc:4.2.3.16-RXN
xref: RHEA:12869
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050553
name: taxadiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene." [EC:4.2.3.17, RHEA:20912]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" RELATED [EC:4.2.3.17]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" RELATED [EC:4.2.3.17]
synonym: "taxa-4(5),11(12)-diene synthase activity" RELATED [EC:4.2.3.17]
xref: EC:4.2.3.17
xref: KEGG_REACTION:R06305
xref: MetaCyc:4.2.3.17-RXN
xref: RHEA:20912
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050554
name: abietadiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, RHEA:13873]
synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" RELATED [EC:4.2.3.18]
synonym: "abietadiene cyclase activity" RELATED [EC:4.2.3.18]
synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" RELATED [EC:4.2.3.18]
xref: EC:4.2.3.18
xref: KEGG_REACTION:R06301
xref: MetaCyc:4.2.3.18-RXN
xref: RHEA:13873
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050555
name: 2-hydroxypropyl-CoM lyase activity
namespace: molecular_function
def: "Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane." [EC:4.4.1.23]
synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" RELATED [EC:4.4.1.23]
synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" RELATED [EC:4.4.1.23]
synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" RELATED [EC:4.4.1.23]
synonym: "coenzyme M-epoxyalkane ligase activity" RELATED [EC:4.4.1.23]
synonym: "EaCoMT activity" RELATED [EC:4.4.1.23]
synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" RELATED [EC:4.4.1.23]
synonym: "epoxyalkane:coenzyme M transferase activity" RELATED [EC:4.4.1.23]
synonym: "epoxyalkane:CoM transferase activity" RELATED [EC:4.4.1.23]
synonym: "epoxyalkyl:CoM transferase activity" RELATED [EC:4.4.1.23]
synonym: "epoxypropane:coenzyme M transferase activity" RELATED [EC:4.4.1.23]
synonym: "epoxypropyl:CoM transferase activity" RELATED [EC:4.4.1.23]
xref: EC:4.4.1.23
xref: MetaCyc:4.2.99.19-RXN
xref: UM-BBD_enzymeID:r0851
xref: UM-BBD_enzymeID:r0858
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050556
name: deacetylisoipecoside synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetylisoipecoside + H2O = dopamine + secologanin." [RHEA:21756]
synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" RELATED [EC:3.5.99.15]
synonym: "deacetylisoipecoside dopamine-lyase activity" RELATED [EC:3.5.99.15]
xref: EC:3.5.99.15
xref: KEGG_REACTION:R05750
xref: MetaCyc:4.3.3.3-RXN
xref: RHEA:21756
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050557
name: deacetylipecoside synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetylipecoside + H2O = dopamine + secologanin." [RHEA:12296]
synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" RELATED [EC:3.5.99.16]
synonym: "deacetylipecoside dopamine-lyase activity" RELATED [EC:3.5.99.16]
xref: EC:3.5.99.16
xref: KEGG_REACTION:R05749
xref: MetaCyc:4.3.3.4-RXN
xref: RHEA:12296
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050558
name: maltose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, RHEA:21228]
synonym: "maltose 1-epimerase activity" RELATED [EC:5.1.3.21]
xref: EC:5.1.3.21
xref: KEGG_REACTION:R07319
xref: MetaCyc:5.1.3.21-RXN
xref: RHEA:21228
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050559
name: copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, RHEA:24316]
synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" RELATED [EC:5.5.1.12]
synonym: "diterpene cyclase activity" BROAD []
xref: EC:5.5.1.12
xref: KEGG_REACTION:R06298
xref: MetaCyc:RXN-4861
xref: RHEA:24316
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0050560
name: aspartate-tRNA(Asn) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN]
synonym: "aspartate-tRNAAsn ligase activity" EXACT []
synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" RELATED [EC:6.1.1.23]
synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23]
xref: EC:6.1.1.23
xref: MetaCyc:6.1.1.23-RXN
xref: RHEA:18349
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050561
name: glutamate-tRNA(Gln) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN]
synonym: "glutamate-tRNAGln ligase activity" EXACT []
synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" RELATED [EC:6.1.1.24]
synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24]
xref: EC:6.1.1.24
xref: MetaCyc:6.1.1.24-RXN
xref: RHEA:18397
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050562
name: obsolete lysine-tRNA(Pyl) ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP." [MetaCyc:6.1.1.25-RXN]
comment: This term was obsoleted because there is no evidence that this activity exists.
synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT []
synonym: "lysine-tRNAPyl ligase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0050563
name: trans-feruloyl-CoA synthase activity
namespace: molecular_function
alt_id: GO:0106287
def: "Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate. ADP + phosphate or AMP + diphosphate may be formed in this reaction." [EC:6.2.1.34, PMID:22649270]
synonym: "ferulate-CoA ligase activity" RELATED []
synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" RELATED [EC:6.2.1.34]
synonym: "trans-feruloyl-CoA synthetase activity" RELATED [EC:6.2.1.34]
xref: EC:6.2.1.34
xref: MetaCyc:6.2.1.34-RXN
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0050564
name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+." [EC:6.3.2.26, RHEA:23196]
synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26]
synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" RELATED [EC:6.3.2.26]
synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" RELATED [EC:6.3.2.26]
synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" RELATED [EC:6.3.2.26]
xref: EC:6.3.2.26
xref: KEGG_REACTION:R04870
xref: MetaCyc:6.3.2.26-RXN
xref: RHEA:23196
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050565
name: aerobactin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H+." [RHEA:32167]
synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT []
synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT []
xref: RHEA:32167
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050566
name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN]
synonym: "Asp-AdT activity" RELATED [EC:6.3.5.6]
synonym: "Asp-tRNA(Asn) amidotransferase activity" RELATED [EC:6.3.5.6]
synonym: "Asp-tRNAAsn amidotransferase activity" RELATED [EC:6.3.5.6]
synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.6]
synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.6]
synonym: "aspartyl-tRNA(Asn) amidotransferase activity" RELATED [EC:6.3.5.6]
synonym: "aspartyl-tRNAAsn amidotransferase activity" RELATED [EC:6.3.5.6]
synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.6]
xref: EC:6.3.5.6
xref: MetaCyc:6.3.5.6-RXN
xref: RHEA:14513
xref: Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0050567
name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
alt_id: GO:0008264
alt_id: GO:0017068
def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]
synonym: "Glu-AdT activity" RELATED [EC:6.3.5.-]
synonym: "Glu-tRNA(Gln) amidotransferase activity" RELATED [EC:6.3.5.-]
synonym: "Glu-tRNAGln amidotransferase activity" RELATED [EC:6.3.5.7]
synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.7]
synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.7]
synonym: "glutamyl-tRNA(Gln) amidotransferase activity" RELATED [EC:6.3.5.-]
synonym: "glutamyl-tRNAGln amidotransferase activity" RELATED [EC:6.3.5.7]
synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.7]
xref: EC:6.3.5.7
xref: MetaCyc:6.3.5.7-RXN
xref: RHEA:17521
xref: Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0050568
name: protein-glutamine glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN]
synonym: "destabilase activity" RELATED [EC:3.5.1.44]
synonym: "glutaminyl-peptide glutaminase activity" RELATED [EC:3.5.1.44]
synonym: "glutaminylpeptide glutaminase activity" RELATED [EC:3.5.1.44]
synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44]
synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44]
synonym: "protein-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.44]
xref: EC:3.5.1.44
xref: MetaCyc:CHEBDEAMID-RXN
xref: RHEA:16441
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0050569
name: glycolaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolaldehyde + H2O + NAD+ = glycolate + 2 H+ + NADH." [RHEA:20001]
synonym: "glycol aldehyde dehydrogenase activity" RELATED [EC:1.2.1.21]
synonym: "glycolaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.21]
xref: EC:1.2.1.21
xref: KEGG_REACTION:R01333
xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN
xref: RHEA:20001
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0050570
name: 4-hydroxythreonine-4-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(phosphooxy)-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH." [EC:1.1.1.262, RHEA:32275]
synonym: "L-threonine 4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.262]
synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.262]
synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.262]
xref: EC:1.1.1.262
xref: MetaCyc:RXN-13179
xref: RHEA:32275
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050571
name: 1,5-anhydro-D-fructose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH." [EC:1.1.1.263, RHEA:20665]
synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.263]
synonym: "AF reductase activity" RELATED [EC:1.1.1.263]
xref: EC:1.1.1.263
xref: KEGG_REACTION:R05682
xref: MetaCyc:1.1.1.263-RXN
xref: RHEA:20665
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050572
name: L-idonate 5-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264]
synonym: "L-idonate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.264]
xref: EC:1.1.1.264
xref: MetaCyc:1.1.1.264-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050573
name: dTDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H+ + NADPH." [EC:1.1.1.266, RHEA:36583]
synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" RELATED [EC:1.1.1.266]
synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.266]
xref: EC:1.1.1.266
xref: KEGG_REACTION:R05687
xref: MetaCyc:1.1.1.266-RXN
xref: RHEA:36583
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050574
name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH." [EC:1.1.1.268, RHEA:13249]
synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" RELATED [EC:1.1.1.268]
synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.268]
xref: EC:1.1.1.268
xref: KEGG_REACTION:R05689
xref: MetaCyc:1.1.1.268-RXN
xref: RHEA:13249
xref: UM-BBD_reactionID:r0852
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050575
name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH." [EC:1.1.1.269, RHEA:21052]
synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" RELATED [EC:1.1.1.269]
synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.269]
xref: EC:1.1.1.269
xref: KEGG_REACTION:R05690
xref: MetaCyc:1.1.1.269-RXN
xref: RHEA:21052
xref: UM-BBD_reactionID:r0853
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050577
name: GDP-L-fucose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]
synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" RELATED [EC:1.1.1.271]
synonym: "GDP-fucose synthetase activity" RELATED [EC:1.1.1.271]
synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" RELATED [EC:1.1.1.271]
xref: EC:1.1.1.271
xref: MetaCyc:1.1.1.271-RXN
xref: Reactome:R-HSA-6787642 "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc"
xref: RHEA:18885
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050578
name: (R)-2-hydroxyacid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN]
synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.272]
synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" RELATED [EC:1.1.1.272]
synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.272]
synonym: "L-sulfolactate dehydrogenase activity" RELATED [EC:1.1.1.272]
xref: EC:1.1.1.272
xref: MetaCyc:1.1.1.272-RXN
xref: RHEA:35735
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050579
name: vellosimine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deoxysarpagine + NADP+ = H+ + NADPH + vellosimine." [EC:1.1.1.273, RHEA:20029]
synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.273]
xref: EC:1.1.1.273
xref: KEGG_REACTION:R05827
xref: MetaCyc:1.1.1.273-RXN
xref: RHEA:20029
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050580
name: 2,5-didehydrogluconate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN]
synonym: "2,5-diketo-D-gluconate reductase activity" RELATED [EC:1.1.1.274]
synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.274]
synonym: "YqhE reductase" RELATED [EC:1.1.1.274]
xref: EC:1.1.1.274
xref: MetaCyc:1.1.1.274-RXN
xref: RHEA:23828
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050581
name: D-mannitol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN]
synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40]
synonym: "D-arabitol oxidase activity" RELATED [EC:1.1.3.40]
synonym: "mannitol oxidase activity" RELATED [EC:1.1.3.40]
synonym: "mannitol:oxygen oxidoreductase (cyclizing)" RELATED [EC:1.1.3.40]
xref: EC:1.1.3.40
xref: MetaCyc:1.1.3.40-RXN
xref: RHEA:18513
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050582
name: xylitol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN]
synonym: "xylitol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.41]
xref: EC:1.1.3.41
xref: MetaCyc:1.1.3.41-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050583
name: hydrogen dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN]
synonym: "hydrogen:NADP+ oxidoreductase activity" RELATED [EC:1.12.1.3]
synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3]
synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3]
xref: EC:1.12.1.3
xref: MetaCyc:1.12.1.3-RXN
xref: RHEA:18637
is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

[Term]
id: GO:0050584
name: linoleate 11-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, RHEA:18993]
synonym: "linoleate dioxygenase activity" RELATED [EC:1.13.11.45]
synonym: "linoleate:oxygen 11S-oxidoreductase activity" RELATED [EC:1.13.11.45]
synonym: "manganese lipoxygenase activity" RELATED [EC:1.13.11.45]
xref: EC:1.13.11.45
xref: KEGG_REACTION:R05718
xref: MetaCyc:1.13.11.45-RXN
xref: RHEA:18993
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050585
name: 4-hydroxymandelate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN]
synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46]
xref: EC:1.13.11.46
xref: MetaCyc:1.13.11.46-RXN
xref: Reactome:R-HSA-9856718 "HPDL dioxygenates HPPA"
xref: RHEA:21376
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050586
name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H+ + O2 = N-acetylanthranilate + CO." [EC:1.13.11.48, RHEA:21572]
synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" RELATED [EC:1.13.11.48]
synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT []
synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT []
synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" RELATED [EC:1.13.11.48]
synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT []
xref: EC:1.13.11.48
xref: KEGG_REACTION:R05720
xref: MetaCyc:1.13.11.48-RXN
xref: RHEA:21572
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050587
name: chlorite O2-lyase activity
namespace: molecular_function
alt_id: GO:0030065
def: "Catalysis of the reaction: chloride + O2 = chlorite." [EC:1.13.11.49, RHEA:21404]
synonym: "chloride:oxygen oxidoreductase activity" RELATED [EC:1.13.11.49]
synonym: "chlorite dismutase activity" RELATED [EC:1.13.11.49]
xref: EC:1.13.11.49
xref: KEGG_REACTION:R05721
xref: MetaCyc:1.13.11.49-RXN
xref: RHEA:21404
xref: UM-BBD_reactionID:r0982
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050588
name: apo-beta-carotenoid-14',13'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal." [EC:1.13.11.67, RHEA:26023]
synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" RELATED [EC:1.13.11.67]
synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT []
xref: EC:1.13.11.67
xref: KEGG_REACTION:R08889
xref: MetaCyc:1.13.12.12-RXN
xref: RHEA:26023
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050589
name: leucocyanidin oxygenase activity
namespace: molecular_function
alt_id: GO:0045432
def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.20.4]
synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.20.4]
synonym: "leucoanthocyanidin dioxygenase activity" RELATED [EC:1.14.20.4]
synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.20.4]
synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" RELATED [EC:1.14.20.4]
xref: EC:1.14.20.4
xref: MetaCyc:RXN-602
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0050590
name: desacetoxyvindoline 4-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN]
synonym: "D17H activity" RELATED [EC:1.14.11.20]
synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" RELATED [EC:1.14.11.20]
synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" RELATED [EC:1.14.11.20]
synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" RELATED [EC:1.14.11.20]
synonym: "desacetoxyvindoline-4-hydroxylase activity" RELATED [EC:1.14.11.20]
synonym: "desacetyoxyvindoline-17-hydroxylase activity" RELATED [EC:1.14.11.20]
xref: EC:1.14.11.20
xref: KEGG_REACTION:R05857
xref: MetaCyc:1.14.11.20-RXN
xref: RHEA:18973
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0050591
name: quinine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+." [EC:1.14.14.55, RHEA:20149]
synonym: "nifedipine oxidase activity" RELATED [EC:1.14.14.55]
synonym: "quinine 3-hydroxylase activity" EXACT []
synonym: "quinine,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.55]
xref: EC:1.14.14.55
xref: KEGG_REACTION:R05727
xref: MetaCyc:1.14.13.67-RXN
xref: RHEA:20149
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050592
name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H+ + NADPH + O2 = (S)-4-hydroxymandelonitrile + 2 H2O + NADP+." [EC:1.14.14.37, RHEA:18401]
synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.37]
synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" RELATED [EC:1.14.14.37]
synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.37]
synonym: "CYP71E1 activity" NARROW [EC:1.14.14.37]
synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.14.37]
synonym: "cytochrome P450II-dependent monooxygenase activity" RELATED [EC:1.14.14.37]
synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" RELATED [EC:1.14.14.37]
xref: EC:1.14.14.37
xref: KEGG_REACTION:R05728
xref: MetaCyc:1.14.13.68-RXN
xref: RHEA:18401
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050593
name: N-methylcoclaurine 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-N-methylcoclaurine + H+ + NADPH + O2 = (S)-3'-hydroxy-N-methylcoclaurine + H2O + NADP+." [EC:1.14.14.102, RHEA:16649]
synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" RELATED [EC:1.14.14.102]
synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.102]
synonym: "cytochrome P450 80B1 activity" RELATED [EC:1.14.14.102]
synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT []
xref: EC:1.14.14.102
xref: KEGG_REACTION:R05732
xref: MetaCyc:1.14.13.71-RXN
xref: RHEA:16649
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050594
name: tabersonine 16-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + tabersonine = 16-hydroxytabersonine + H2O + NADP+." [EC:1.14.14.103, RHEA:14133]
synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" RELATED [EC:1.14.14.103]
xref: EC:1.14.14.103
xref: KEGG_REACTION:R05855
xref: MetaCyc:1.14.13.73-RXN
xref: RHEA:14133
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050595
name: 7-deoxyloganin 7-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase]." [PMID:11524113, RHEA:11452]
xref: MetaCyc:1.14.13.74-RXN
xref: RHEA:11452
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050596
name: vinorine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + vinorine = H2O + NADP+ + vomilenine." [EC:1.14.14.104, RHEA:17257]
synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" RELATED [EC:1.14.14.104]
xref: EC:1.14.14.104
xref: KEGG_REACTION:R05877
xref: MetaCyc:1.14.13.75-RXN
xref: RHEA:17257
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050597
name: taxane 10-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP+." [EC:1.14.14.105, RHEA:15241]
synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" RELATED [EC:1.14.14.105]
synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" RELATED [EC:1.14.14.105]
synonym: "taxane 10b-hydroxylase activity" EXACT []
synonym: "taxane 10beta-hydroxylase activity" RELATED [EC:1.14.14.105]
xref: EC:1.14.14.105
xref: KEGG_REACTION:R06309
xref: MetaCyc:1.14.13.76-RXN
xref: RHEA:15241
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050598
name: taxane 13-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5alpha,13alpha-diol." [EC:1.14.14.106, RHEA:18949]
synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" RELATED [EC:1.14.14.106]
synonym: "taxane 13a-hydroxylase activity" EXACT []
synonym: "taxane 13alpha-hydroxylase activity" RELATED [EC:1.14.14.106]
xref: EC:1.14.14.106
xref: KEGG_REACTION:R06308
xref: MetaCyc:1.14.13.77-RXN
xref: RHEA:18949
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050599
name: deacetoxycephalosporin-C synthase activity
namespace: molecular_function
alt_id: GO:0045441
def: "Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate." [EC:1.14.20.1, RHEA:20748]
synonym: "DAOC synthase activity" RELATED [EC:1.14.20.1]
synonym: "DAOCS activity" RELATED [EC:1.14.20.1]
synonym: "deacetoxycephalosporin C synthetase activity" EXACT []
synonym: "expandase activity" EXACT []
synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1]
synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" RELATED [EC:1.14.20.1]
xref: EC:1.14.20.1
xref: KEGG_REACTION:R05301
xref: MetaCyc:1.14.20.1-RXN
xref: RHEA:20748
is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

[Term]
id: GO:0050600
name: acyl-CoA 11-(E)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11E)-delta11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." [RHEA:46396]
synonym: "acyl-CoA delta11-desaturase activity" BROAD []
synonym: "myristoyl-CoA 11-(E) desaturase activity" NARROW []
xref: EC:1.14.19.24
xref: MetaCyc:1.14.99.31-RXN
xref: RHEA:46396
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0050602
name: obsolete monoprenyl isoflavone epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [GOC:curators]
comment: This term was obsoleted because no enzyme has been shown to catalyze this reaction.
is_obsolete: true

[Term]
id: GO:0050603
name: thiophene-2-carbonyl-CoA monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O + H+." [EC:1.14.99.35, RHEA:18929]
synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" RELATED [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" RELATED [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" RELATED [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" RELATED [EC:1.14.99.35]
xref: EC:1.14.99.35
xref: KEGG_REACTION:R05742
xref: MetaCyc:1.14.99.35-RXN
xref: RHEA:18929
xref: UM-BBD_reactionID:r1235
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050604
name: taxadiene 5-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol." [RHEA:14049]
synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" RELATED []
synonym: "taxadiene 5a-hydroxylase activity" EXACT []
synonym: "taxadiene 5alpha-hydroxylase activity" RELATED []
xref: EC:1.14.14.176
xref: KEGG_REACTION:R06306
xref: MetaCyc:1.14.99.37-RXN
xref: RHEA:14049
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050605
name: superoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN]
synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2]
synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2]
synonym: "rubredoxin:superoxide oxidoreductase activity" RELATED [EC:1.15.1.2]
xref: EC:1.15.1.2
xref: MetaCyc:1.15.1.2-RXN
xref: RHEA:21324
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0050606
name: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + H+ + NADPH." [RHEA:29587]
synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" RELATED [EC:1.1.1.312]
synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity" RELATED [EC:1.1.1.312]
synonym: "4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity" RELATED [EC:1.1.1.312]
synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" RELATED [EC:1.1.1.312]
xref: EC:1.1.1.312
xref: KEGG_REACTION:R04279
xref: MetaCyc:1.2.1.45-RXN
xref: RHEA:29587
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050607
name: mycothiol-dependent formaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.1.1.306]
synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT []
synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.306]
xref: EC:1.1.1.306
xref: MetaCyc:1.2.1.66-RXN
xref: RHEA:28502
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050608
name: vanillin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + vanillin = 2 H+ + NADH + vanillate." [EC:1.2.1.67, RHEA:13309]
synonym: "vanillin:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.67]
xref: EC:1.2.1.67
xref: KEGG_REACTION:R05699
xref: MetaCyc:1.2.1.67-RXN
xref: RHEA:13309
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050609
name: phosphonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + phosphonate = 2 H+ + NADH + phosphate." [EC:1.20.1.1, RHEA:13173]
synonym: "NAD-dependent phosphite dehydrogenas activity" RELATED [EC:1.20.1.1]
synonym: "NAD:phosphite oxidoreductase activity" RELATED [EC:1.20.1.1]
synonym: "phosphite dehydrogenase activity" RELATED [EC:1.20.1.1]
synonym: "phosphonate:NAD+ oxidoreductase activity" RELATED [EC:1.20.1.1]
xref: EC:1.20.1.1
xref: KEGG_REACTION:R05746
xref: MetaCyc:1.20.1.1-RXN
xref: RHEA:13173
xref: UM-BBD_reactionID:r1055
is_a: GO:0050499 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor

[Term]
id: GO:0050610
name: methylarsonate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid." [EC:1.20.4.2, RHEA:15969]
synonym: "glutathione:methylarsonate oxidoreductase activity" RELATED [EC:1.20.4.2]
synonym: "MMA(V) reductase activity" RELATED [EC:1.20.4.2]
xref: EC:1.20.4.2
xref: KEGG_REACTION:R05748
xref: MetaCyc:1.20.4.2-RXN
xref: Reactome:R-HSA-5696230 "GSTO1 dimer reduces methylarsonate to methylarsonite"
xref: RHEA:15969
xref: UM-BBD_reactionID:r0837
is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor

[Term]
id: GO:0050611
name: arsenate reductase (azurin) activity
namespace: molecular_function
alt_id: GO:0018691
def: "Catalysis of the reaction: H2O + arsenite + 2 oxidized azurin = 2 H+ + 2 reduced azurin + arsenate." [EC:1.20.9.1, MetaCyc:1.20.98.1-RXN]
synonym: "arsenite oxidase activity" RELATED [EC:1.20.9.1]
synonym: "arsenite:azurin oxidoreductase activity" RELATED [EC:1.20.9.1]
xref: EC:1.20.9.1
xref: MetaCyc:1.20.98.1-RXN
xref: RHEA:18701
xref: UM-BBD_reactionID:r0634
is_a: GO:0052882 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor

[Term]
id: GO:0050612
name: arsenate reductase (donor) activity
namespace: molecular_function
def: "Catalysis of the reaction: A + arsenite + H2O = AH(2) + arsenate + 2 H+." [EC:1.20.99.1, RHEA:18449]
synonym: "arsenate:(acceptor) oxidoreductase activity" RELATED [EC:1.20.99.1]
synonym: "arsenate:acceptor oxidoreductase activity" RELATED [EC:1.20.99.1]
xref: EC:1.20.99.1
xref: KEGG_REACTION:R05752
xref: MetaCyc:1.20.99.1-RXN
xref: RHEA:18449
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050613
name: Delta14-sterol reductase activity
namespace: molecular_function
alt_id: GO:0000251
def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" RELATED [EC:1.3.1.70]
synonym: "C-14 sterol reductase activity" EXACT []
synonym: "D14-sterol reductase activity" EXACT []
synonym: "sterol C-14 reductase activity" EXACT []
synonym: "sterol C14-reductase activity" RELATED [EC:1.3.1.70]
xref: EC:1.3.1.70
xref: MetaCyc:RXN66-14
xref: Reactome:R-HSA-194674 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]"
xref: Reactome:R-HSA-194698 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]"
xref: RHEA:18561
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050614
name: Delta24-sterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72]
synonym: "D24-sterol reductase activity" EXACT []
synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72]
synonym: "lanosterol delta24-reductase activity" RELATED [EC:1.3.1.72]
synonym: "sterol:NADP+ delta24-oxidoreductase activity" RELATED [EC:1.3.1.72]
xref: EC:1.3.1.72
xref: MetaCyc:RXN66-321
xref: Reactome:R-HSA-196417 "Reduction of desmosterol to cholesterol"
xref: Reactome:R-HSA-6807064 "DHCR24 reduces ZYMOL to ZYMSTNL"
xref: Reactome:R-HSA-9755937 "DHCR24 reduces LAN to 24,25-dhLAN"
xref: RHEA:13685
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050615
name: 1,2-dihydrovomilenine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + H+ + NADPH." [EC:1.3.1.73, RHEA:12320]
synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.73]
xref: EC:1.3.1.73
xref: KEGG_REACTION:R05879
xref: MetaCyc:1.3.1.73-RXN
xref: RHEA:12320
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050616
name: secologanin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.14.19.62, MetaCyc:1.3.3.9-RXN]
synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" RELATED [EC:1.14.19.62]
xref: EC:1.14.19.62
xref: MetaCyc:1.3.3.9-RXN
xref: RHEA:20585
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050617
name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN]
synonym: "PebA" RELATED [EC:1.3.7.2]
xref: EC:1.3.7.2
xref: MetaCyc:1.3.7.2-RXN
xref: RHEA:10168
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050618
name: phycoerythrobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN]
synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.3]
synonym: "PebB" RELATED [EC:1.3.7.3]
xref: EC:1.3.7.3
xref: MetaCyc:1.3.7.3-RXN
xref: RHEA:22092
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050619
name: phytochromobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN]
synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.4]
synonym: "HY2" RELATED [EC:1.3.7.4]
synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4]
synonym: "PFB synthase activity" RELATED [EC:1.3.7.4]
synonym: "phytochromobilin synthase activity" RELATED [EC:1.3.7.4]
synonym: "PPhiB synthase activity" RELATED [EC:1.3.7.4]
xref: EC:1.3.7.4
xref: MetaCyc:1.3.7.4-RXN
xref: RHEA:16377
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050620
name: phycocyanobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN]
synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.5]
xref: EC:1.3.7.5
xref: MetaCyc:1.3.7.5-RXN
xref: RHEA:15309
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050621
name: tryptophan alpha,beta-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 + H+." [EC:1.3.3.10, RHEA:19901]
comment: Note that this was EC:1.4.3.17.
synonym: "L-tryptophan 2',3'-oxidase activity" RELATED [EC:1.3.3.10]
synonym: "L-tryptophan alpha,beta-dehydrogenase activity" RELATED [EC:1.3.3.10]
synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" RELATED [EC:1.3.3.10]
synonym: "tryptophan a,b-oxidase activity" EXACT []
xref: EC:1.3.3.10
xref: KEGG_REACTION:R05317
xref: MetaCyc:1.4.3.17-RXN
xref: RHEA:19901
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050622
name: glycine dehydrogenase (cyanide-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [RHEA:15821]
synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" RELATED [EC:1.4.99.5]
synonym: "HCN synthase activity" RELATED [EC:1.4.99.5]
synonym: "hydrogen cyanide synthase activity" RELATED [EC:1.4.99.5]
xref: EC:1.4.99.5
xref: MetaCyc:1.4.99.5-RXN
xref: RHEA:15821
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0050623
name: berberine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + H+ + 2 NADPH." [EC:1.5.1.31, RHEA:21268]
synonym: "(R)-canadine synthase activity" RELATED [EC:1.5.1.31]
synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.31]
xref: EC:1.5.1.31
xref: KEGG_REACTION:R07169
xref: MetaCyc:1.5.1.31-RXN
xref: RHEA:21268
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050624
name: vomilenine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = H+ + NADPH + vomilenine." [EC:1.5.1.32, RHEA:16409]
synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.32]
xref: EC:1.5.1.32
xref: KEGG_REACTION:R05878
xref: MetaCyc:1.5.1.32-RXN
xref: RHEA:16409
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050625
name: 2-hydroxy-1,4-benzoquinone reductase activity
namespace: molecular_function
alt_id: GO:0018540
def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H+ + NADH = benzene-1,2,4-triol + NAD+." [EC:1.6.5.7, RHEA:12428]
synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" RELATED [EC:1.6.5.7]
synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" RELATED [EC:1.6.5.7]
synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" RELATED [EC:1.6.5.7]
synonym: "hydroxybenzoquinone reductase activity" RELATED [EC:1.6.5.-]
synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" RELATED [EC:1.6.5.7]
xref: EC:1.6.5.7
xref: KEGG_REACTION:R05399
xref: MetaCyc:1.6.5.7-RXN
xref: RHEA:12428
xref: UM-BBD_reactionID:r0667
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0050626
name: trimethylamine-N-oxide reductase (cytochrome c) activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN]
synonym: "TMAO reductase activity" RELATED [EC:1.7.2.3]
synonym: "TOR activity" RELATED [EC:1.7.2.3]
synonym: "trimethylamine:cytochrome c oxidoreductase activity" RELATED [EC:1.7.2.3]
xref: EC:1.7.2.3
xref: MetaCyc:1.7.2.3-RXN
xref: RHEA:24236
xref: Wikipedia:Trimethylamine_N-oxide_reductase
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0050627
name: mycothione reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN]
synonym: "mycothiol-disulfide reductase activity" RELATED [EC:1.8.1.15]
synonym: "mycothiol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.8.1.15]
xref: EC:1.8.1.15
xref: MetaCyc:1.8.1.15-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050628
name: 2-oxopropyl-CoM reductase (carboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + coenzyme M + NADP+ = 2-oxopropyl-coenzyme M + CO2 + NADPH." [EC:1.8.1.5, RHEA:16977]
synonym: "2-KPCC activity" RELATED [EC:1.8.1.5]
synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" RELATED [EC:1.8.1.5]
synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" RELATED [EC:1.8.1.5]
synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" RELATED [EC:1.8.1.5]
xref: EC:1.8.1.5
xref: KEGG_REACTION:R05713
xref: MetaCyc:1.8.1.5-RXN
xref: RHEA:16977
xref: UM-BBD_reactionID:r0854
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050629
name: tetrachloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. The reaction occurs in the reverse direction." [RHEA:20353]
synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" RELATED [EC:1.21.99.5]
synonym: "tetrachloroethene reductase activity" RELATED [EC:1.21.99.5]
xref: EC:1.21.99.5
xref: MetaCyc:1.97.1.8-RXN
xref: RHEA:20353
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050630
name: (iso)eugenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-isoeugenol + S-adenosyl-L-methionine = (E)-isomethyleugenol + H+ + S-adenosyl-L-homocysteine." [RHEA:17081]
synonym: "isoeugenol O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" RELATED [EC:2.1.1.146]
xref: EC:2.1.1.146
xref: MetaCyc:2.1.1.146-RXN
xref: RHEA:17081
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0050631
name: corydaline synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP+." [EC:2.1.1.147, RHEA:14773]
synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" RELATED [EC:2.1.1.147]
xref: EC:2.1.1.147
xref: KEGG_REACTION:R07241
xref: MetaCyc:2.1.1.147-RXN
xref: RHEA:14773
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0050632
name: propionyl-CoA C2-trimethyltridecanoyltransferase activity
namespace: molecular_function
alt_id: GO:0004770
def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [RHEA:10408]
synonym: "3-oxopristanoyl-CoA hydrolase activity" RELATED [EC:2.3.1.176]
synonym: "3-oxopristanoyl-CoA thiolase activity" RELATED [EC:2.3.1.176]
synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" RELATED [EC:2.3.1.176]
synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" RELATED [EC:2.3.1.176]
synonym: "oxopristanoyl-CoA thiolase activity" RELATED [EC:2.3.1.176]
synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.176]
synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.176]
synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT []
synonym: "SCPx" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein X-related thiolase activity" RELATED []
xref: KEGG_REACTION:R05330
xref: MetaCyc:2.3.1.154-RXN
xref: Reactome:R-HSA-192341 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA"
xref: Reactome:R-HSA-193533 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA"
xref: Reactome:R-HSA-2066781 "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)"
xref: Reactome:R-HSA-390224 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA"
xref: RHEA:10408
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050633
name: acetyl-CoA C-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN]
synonym: "3-oxopalmitoyl-CoA hydrolase activity" RELATED [EC:2.3.1.155]
synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" RELATED [EC:2.3.1.155]
synonym: "myristoyl-CoA C-acetyltransferase activity" RELATED [EC:2.3.1.155]
synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" RELATED [EC:2.3.1.155]
xref: EC:2.3.1.155
xref: MetaCyc:2.3.1.155-RXN
xref: RHEA:18161
is_a: GO:0016408 ! C-acyltransferase activity
is_a: GO:0019107 ! myristoyltransferase activity

[Term]
id: GO:0050634
name: phloroisovalerophenone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN]
synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" RELATED [EC:2.3.1.156]
synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" RELATED [EC:2.3.1.156]
synonym: "valerophenone synthase activity" RELATED [EC:2.3.1.156]
xref: EC:2.3.1.156
xref: MetaCyc:2.3.1.156-RXN
xref: RHEA:23572
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050635
name: acridone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H+ + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O." [EC:2.3.1.159, RHEA:22224]
synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" RELATED [EC:2.3.1.159]
xref: EC:2.3.1.159
xref: KEGG_REACTION:R07250
xref: MetaCyc:2.3.1.159-RXN
xref: RHEA:22224
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050636
name: vinorine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine." [EC:2.3.1.160, RHEA:24016]
synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" RELATED [EC:2.3.1.160]
xref: EC:2.3.1.160
xref: KEGG_REACTION:R05876
xref: MetaCyc:2.3.1.160-RXN
xref: RHEA:24016
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050637
name: lovastatin nonaketide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+." [EC:2.3.1.161, RHEA:18565]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" RELATED [EC:2.3.1.161]
xref: EC:2.3.1.161
xref: KEGG_REACTION:R07251
xref: MetaCyc:2.3.1.161-RXN
xref: RHEA:18565
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050638
name: taxadien-5-alpha-ol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate." [EC:2.3.1.162, RHEA:22028]
synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" RELATED [EC:2.3.1.162]
synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" RELATED [EC:2.3.1.162]
synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" RELATED [EC:2.3.1.162]
synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" RELATED [EC:2.3.1.162]
synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT []
synonym: "taxadien-5alpha-ol O-acetyltransferase activity" RELATED [EC:2.3.1.162]
synonym: "taxadienol acetyltransferase activity" RELATED [EC:2.3.1.162]
xref: EC:2.3.1.162
xref: KEGG_REACTION:R06307
xref: MetaCyc:2.3.1.162-RXN
xref: RHEA:22028
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050639
name: 10-hydroxytaxane O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C." [EC:2.3.1.163, RHEA:18837]
synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" RELATED [EC:2.3.1.163]
synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" RELATED [EC:2.3.1.163]
synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163]
xref: EC:2.3.1.163
xref: KEGG_REACTION:R07252
xref: MetaCyc:2.3.1.163-RXN
xref: RHEA:18837
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050640
name: isopenicillin-N N-acyltransferase activity
namespace: molecular_function
alt_id: GO:0042319
alt_id: GO:0045440
def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminoadipate." [RHEA:20720]
synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" RELATED [EC:2.3.1.164]
synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" RELATED [EC:2.3.1.164]
synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" RELATED [EC:2.3.1.164]
synonym: "isopenicillin N:acyl-CoA acyltransferase activity" RELATED [EC:2.3.1.164]
synonym: "isopenicillin-N acyltransferase activity" EXACT []
xref: EC:2.3.1.164
xref: MetaCyc:2.3.1.164-RXN
xref: RHEA:20720
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0050641
name: 6-methylsalicylic acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+." [EC:2.3.1.165, RHEA:12240]
synonym: "6-MSAS activity" RELATED [EC:2.3.1.165]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" RELATED [EC:2.3.1.165]
synonym: "MSAS activity" RELATED [EC:2.3.1.165]
xref: EC:2.3.1.165
xref: KEGG_REACTION:R07253
xref: MetaCyc:2.3.1.165-RXN
xref: RHEA:12240
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050642
name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA." [RHEA:18741]
synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" RELATED [EC:2.3.1.166]
synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT []
synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" RELATED [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" RELATED [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" RELATED [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" RELATED [EC:2.3.1.166]
xref: EC:2.3.1.166
xref: KEGG_REACTION:R06310
xref: MetaCyc:2.3.1.166-RXN
xref: RHEA:18741
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050643
name: 10-deacetylbaccatin III 10-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA." [EC:2.3.1.167, RHEA:20137]
synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167]
xref: EC:2.3.1.167
xref: KEGG_REACTION:R06311
xref: MetaCyc:2.3.1.167-RXN
xref: RHEA:20137
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050644
name: cis-p-coumarate glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H+ + UDP." [EC:2.4.1.209, RHEA:13129]
synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.209]
xref: EC:2.4.1.209
xref: KEGG_REACTION:R05324
xref: MetaCyc:2.4.1.209-RXN
xref: RHEA:13129
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050645
name: limonoid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210]
synonym: "LGTase activity" RELATED [EC:2.4.1.210]
synonym: "limonoid UDP-glucosyltransferase activity" RELATED [EC:2.4.1.210]
synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" RELATED [EC:2.4.1.210]
xref: EC:2.4.1.210
xref: MetaCyc:2.4.1.210-RXN
xref: RHEA:11256
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050646
name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding
is_a: GO:0050542 ! icosanoid binding

[Term]
id: GO:0050647
name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding
is_a: GO:0050542 ! icosanoid binding
is_a: GO:1901567 ! fatty acid derivative binding

[Term]
id: GO:0050648
name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding
is_a: GO:0050542 ! icosanoid binding
is_a: GO:1901567 ! fatty acid derivative binding

[Term]
id: GO:0050649
name: testosterone 6-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:11726664, RHEA:46296]
synonym: "testosterone 6b-hydroxylase activity" EXACT []
xref: RHEA:46296
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0050650
name: chondroitin sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]
synonym: "chondroitin sulfate proteoglycan anabolism" EXACT []
synonym: "chondroitin sulfate proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulfate proteoglycan formation" EXACT []
synonym: "chondroitin sulfate proteoglycan synthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthetic process" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process

[Term]
id: GO:0050651
name: dermatan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]
synonym: "chondroitin sulfate B proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulfate B proteoglycan biosynthetic process" EXACT []
synonym: "dermatan sulfate proteoglycan anabolism" EXACT []
synonym: "dermatan sulfate proteoglycan biosynthesis" EXACT []
synonym: "dermatan sulfate proteoglycan formation" EXACT []
synonym: "dermatan sulfate proteoglycan synthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthetic process" EXACT []
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0050655 ! dermatan sulfate proteoglycan metabolic process

[Term]
id: GO:0050652
name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602]
synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
synonym: "chondroitin sulfate B proteoglycan chain elongation" EXACT []
synonym: "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "dermatan sulfate proteoglycan chain elongation" EXACT []
synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0050653
name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602]
synonym: "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "chondroitin sulfate proteoglycan chain elongation" EXACT []
synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process

[Term]
id: GO:0050654
name: chondroitin sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]
synonym: "chondroitin sulfate proteoglycan metabolism" EXACT []
synonym: "chondroitin sulphate proteoglycan metabolic process" EXACT []
synonym: "chondroitin sulphate proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0050655
name: dermatan sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]
synonym: "chondroitin sulfate B proteoglycan metabolic process" EXACT []
synonym: "chondroitin sulfate B proteoglycan metabolism" EXACT []
synonym: "dermatan sulfate proteoglycan metabolism" EXACT []
synonym: "dermatan sulphate proteoglycan metabolic process" EXACT []
synonym: "dermatan sulphate proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process

[Term]
id: GO:0050656
name: 3'-phosphoadenosine 5'-phosphosulfate binding
namespace: molecular_function
def: "Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai]
synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT []
synonym: "3'-phosphoadenylyl-sulfate binding" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT []
synonym: "PAPS binding" EXACT []
synonym: "phosphoadenosine phosphosulfate binding" EXACT []
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0050657
name: nucleic acid transport
namespace: biological_process
def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
is_a: GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0050658
name: RNA transport
namespace: biological_process
def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport
is_a: GO:0051236 ! establishment of RNA localization

[Term]
id: GO:0050659
name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reactions: n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H+, and n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H+." [EC:2.8.2.33]
synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" RELATED [EC:2.8.2.33]
synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33]
synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" RELATED [EC:2.8.2.33]
xref: EC:2.8.2.33
xref: Reactome:R-HSA-2018659 "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050660
name: flavin adenine dinucleotide binding
namespace: molecular_function
def: "Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]
synonym: "FAD or FADH2 binding" EXACT []
synonym: "flavine-adenine dinucleotide binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0050661
name: NADP binding
namespace: molecular_function
def: "Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
synonym: "NADP or NADPH binding" RELATED [GOC:mah]
synonym: "NADP+ or NADPH binding" RELATED []
synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT []
is_a: GO:0030554 ! adenyl nucleotide binding

[Term]
id: GO:0050662
name: obsolete coenzyme binding
namespace: molecular_function
def: "OBSOLETE. Binding to a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a coenzyme.
is_obsolete: true

[Term]
id: GO:0050664
name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]
synonym: "oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor" RELATED []
xref: EC:1.6.3.-
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0050665
name: hydrogen peroxide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai]
synonym: "H2O2 biosynthetic process" EXACT [GOC:mah]
synonym: "hydrogen peroxide anabolism" EXACT []
synonym: "hydrogen peroxide biosynthesis" EXACT []
synonym: "hydrogen peroxide formation" EXACT []
synonym: "hydrogen peroxide generation" EXACT []
synonym: "hydrogen peroxide synthesis" EXACT []
is_a: GO:0042743 ! hydrogen peroxide metabolic process
is_a: GO:1903409 ! reactive oxygen species biosynthetic process

[Term]
id: GO:0050666
name: regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai]
synonym: "regulation of Hcy metabolic process" EXACT []
synonym: "regulation of Hcy metabolism" EXACT []
synonym: "regulation of homocysteine metabolism" EXACT []
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
relationship: regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050667
name: homocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732]
synonym: "Hcy metabolic process" EXACT []
synonym: "Hcy metabolism" EXACT []
synonym: "homocysteine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0050668
name: positive regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]
synonym: "activation of homocysteine metabolic process" NARROW []
synonym: "positive regulation of Hcy metabolic process" EXACT []
synonym: "positive regulation of Hcy metabolism" EXACT []
synonym: "positive regulation of homocysteine metabolism" EXACT []
synonym: "stimulation of homocysteine metabolic process" NARROW []
synonym: "up regulation of homocysteine metabolic process" EXACT []
synonym: "up-regulation of homocysteine metabolic process" EXACT []
synonym: "upregulation of homocysteine metabolic process" EXACT []
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0050666 ! regulation of homocysteine metabolic process
relationship: positively_regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050669
name: negative regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]
synonym: "down regulation of homocysteine metabolic process" EXACT []
synonym: "down-regulation of homocysteine metabolic process" EXACT []
synonym: "downregulation of homocysteine metabolic process" EXACT []
synonym: "inhibition of homocysteine metabolic process" NARROW []
synonym: "negative regulation of Hcy metabolic process" EXACT []
synonym: "negative regulation of Hcy metabolism" EXACT []
synonym: "negative regulation of homocysteine metabolism" EXACT []
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0050666 ! regulation of homocysteine metabolic process
relationship: negatively_regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050670
name: regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai]
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050671
name: positive regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "activation of lymphocyte proliferation" NARROW []
synonym: "stimulation of lymphocyte proliferation" NARROW []
synonym: "up regulation of lymphocyte proliferation" EXACT []
synonym: "up-regulation of lymphocyte proliferation" EXACT []
synonym: "upregulation of lymphocyte proliferation" EXACT []
is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050672
name: negative regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "down regulation of lymphocyte proliferation" EXACT []
synonym: "down-regulation of lymphocyte proliferation" EXACT []
synonym: "downregulation of lymphocyte proliferation" EXACT []
synonym: "inhibition of lymphocyte proliferation" NARROW []
is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050673
name: epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0050674
name: urothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050675
name: regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050676
name: negative regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai]
synonym: "down regulation of urothelial cell proliferation" EXACT []
synonym: "down-regulation of urothelial cell proliferation" EXACT []
synonym: "downregulation of urothelial cell proliferation" EXACT []
synonym: "inhibition of urothelial cell proliferation" NARROW []
is_a: GO:0050675 ! regulation of urothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
relationship: negatively_regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050677
name: positive regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai]
synonym: "activation of urothelial cell proliferation" NARROW []
synonym: "stimulation of urothelial cell proliferation" NARROW []
synonym: "up regulation of urothelial cell proliferation" EXACT []
synonym: "up-regulation of urothelial cell proliferation" EXACT []
synonym: "upregulation of urothelial cell proliferation" EXACT []
is_a: GO:0050675 ! regulation of urothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
relationship: positively_regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050678
name: regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050679
name: positive regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "activation of epithelial cell proliferation" NARROW []
synonym: "stimulation of epithelial cell proliferation" NARROW []
synonym: "up regulation of epithelial cell proliferation" EXACT []
synonym: "up-regulation of epithelial cell proliferation" EXACT []
synonym: "upregulation of epithelial cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: positively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050680
name: negative regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "down regulation of epithelial cell proliferation" EXACT []
synonym: "down-regulation of epithelial cell proliferation" EXACT []
synonym: "downregulation of epithelial cell proliferation" EXACT []
synonym: "inhibition of epithelial cell proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050681
name: nuclear androgen receptor binding
namespace: molecular_function
def: "Binding to a nuclear androgen receptor." [GOC:ai]
synonym: "androgen receptor binding" BROAD []
synonym: "AR binding" EXACT []
is_a: GO:0016922 ! nuclear receptor binding

[Term]
id: GO:0050682
name: AF-2 domain binding
namespace: molecular_function
def: "Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050683
name: AF-1 domain binding
namespace: molecular_function
def: "Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050684
name: regulation of mRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]
is_a: GO:1903311 ! regulation of mRNA metabolic process
relationship: regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050685
name: positive regulation of mRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai]
synonym: "activation of mRNA processing" NARROW []
synonym: "stimulation of mRNA processing" NARROW []
synonym: "up regulation of mRNA processing" EXACT []
synonym: "up-regulation of mRNA processing" EXACT []
synonym: "upregulation of mRNA processing" EXACT []
is_a: GO:0050684 ! regulation of mRNA processing
is_a: GO:1903313 ! positive regulation of mRNA metabolic process
relationship: positively_regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050686
name: negative regulation of mRNA processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai]
synonym: "down regulation of mRNA processing" EXACT []
synonym: "down-regulation of mRNA processing" EXACT []
synonym: "downregulation of mRNA processing" EXACT []
synonym: "inhibition of mRNA processing" NARROW []
is_a: GO:0050684 ! regulation of mRNA processing
is_a: GO:1903312 ! negative regulation of mRNA metabolic process
relationship: negatively_regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050687
name: negative regulation of defense response to virus
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai]
synonym: "down regulation of antiviral response" EXACT []
synonym: "down-regulation of antiviral response" EXACT []
synonym: "downregulation of antiviral response" EXACT []
synonym: "inhibition of antiviral response" NARROW []
synonym: "negative regulation of antiviral response" EXACT [GOC:dph]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0050688 ! regulation of defense response to virus
relationship: negatively_regulates GO:0051607 ! defense response to virus

[Term]
id: GO:0050688
name: regulation of defense response to virus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]
synonym: "regulation of antiviral response" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0051607 ! defense response to virus

[Term]
id: GO:0050689
name: negative regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of antiviral response by host" EXACT []
synonym: "down-regulation of antiviral response by host" EXACT []
synonym: "downregulation of antiviral response by host" EXACT []
synonym: "inhibition of antiviral response by host" NARROW []
synonym: "negative regulation by host of antiviral response" EXACT []
synonym: "negative regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050687 ! negative regulation of defense response to virus
is_a: GO:0050691 ! regulation of defense response to virus by host

[Term]
id: GO:0050691
name: regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph]
synonym: "host regulation of antiviral response" EXACT []
synonym: "regulation by host of antiviral response" EXACT []
synonym: "regulation of antiviral response by host" RELATED [GOC:dph]
is_a: GO:0050688 ! regulation of defense response to virus

[Term]
id: GO:0050692
name: DNA binding domain binding
namespace: molecular_function
def: "Binding to a protein's DNA binding domain (DBD)." [PMID:9682036]
synonym: "DBD binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050693
name: LBD domain binding
namespace: molecular_function
def: "Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036]
synonym: "ligand binding domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050694
name: galactose 3-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829]
synonym: "Gal-3-O-sulfotransferase activity" EXACT []
synonym: "galactose 3-O-sulphotransferase activity" EXACT []
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050695
name: benzoylformate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN]
synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" RELATED [EC:4.1.1.7]
synonym: "benzoylformate carboxy-lyase activity" RELATED [EC:4.1.1.7]
synonym: "phenylglyoxylate decarboxylase activity" EXACT []
xref: EC:4.1.1.7
xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN
xref: RHEA:23368
xref: UM-BBD_reactionID:r1049
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050696
name: trichloroethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai]
synonym: "trichloroethene catabolic process" EXACT []
synonym: "trichloroethene catabolism" EXACT []
synonym: "trichloroethylene breakdown" EXACT []
synonym: "trichloroethylene catabolism" EXACT []
synonym: "trichloroethylene degradation" EXACT []
is_a: GO:0018979 ! trichloroethylene metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0050697
name: trichloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + trichloroethene = (Z)-1,2-dichloroethene + A + chloride + H+." [RHEA:67992]
synonym: "1,1,2-trichloroethene reductive dehalogenase activity" EXACT []
synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT []
synonym: "TCE-reductive dehalogenase activity" EXACT []
xref: MetaCyc:TCEREDCHLOR-RXN
xref: RHEA:67992
xref: UM-BBD_enzymeID:r0350
xref: UM-BBD_enzymeID:r0932
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050698
name: proteoglycan sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [GOC:ai]
synonym: "proteoglycan sulfate transfer" RELATED []
synonym: "proteoglycan sulphotransferase activity" EXACT []
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050699
name: WW domain binding
namespace: molecular_function
def: "Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050700
name: CARD domain binding
namespace: molecular_function
def: "Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050708
name: regulation of protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050709
name: negative regulation of protein secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "down regulation of protein secretion" EXACT []
synonym: "down-regulation of protein secretion" EXACT []
synonym: "downregulation of protein secretion" EXACT []
synonym: "inhibition of protein secretion" NARROW []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903531 ! negative regulation of secretion by cell
relationship: negatively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050714
name: positive regulation of protein secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "activation of protein secretion" NARROW []
synonym: "stimulation of protein secretion" NARROW []
synonym: "up regulation of protein secretion" EXACT []
synonym: "up-regulation of protein secretion" EXACT []
synonym: "upregulation of protein secretion" EXACT []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903532 ! positive regulation of secretion by cell
relationship: positively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050727
name: regulation of inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050728
name: negative regulation of inflammatory response
namespace: biological_process
alt_id: GO:0030236
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "anti-inflammatory response" EXACT []
synonym: "down regulation of inflammatory response" EXACT []
synonym: "down-regulation of inflammatory response" EXACT []
synonym: "downregulation of inflammatory response" EXACT []
synonym: "inhibition of inflammatory response" NARROW []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
relationship: negatively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050729
name: positive regulation of inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "activation of inflammatory response" NARROW []
synonym: "stimulation of inflammatory response" NARROW []
synonym: "up regulation of inflammatory response" EXACT []
synonym: "up-regulation of inflammatory response" EXACT []
synonym: "upregulation of inflammatory response" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
relationship: positively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050730
name: regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0001932 ! regulation of protein phosphorylation
relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050731
name: positive regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW []
synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW []
synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT []
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050732
name: negative regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW []
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050733
name: RS domain binding
namespace: molecular_function
def: "Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050734
name: hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0050735
name: N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0050736
name: O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0050737
name: O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0050734 ! hydroxycinnamoyltransferase activity

[Term]
id: GO:0050738
name: fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0050739
name: obsolete peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium
namespace: biological_process
def: "OBSOLETE. The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0348
is_obsolete: true

[Term]
id: GO:0050740
name: obsolete protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine." [RESID:AA0349]
comment: This is a molecular function.
xref: RESID:AA0349
is_obsolete: true

[Term]
id: GO:0050741
name: obsolete protein-FMN linkage via O3-riboflavin phosphoryl-L-serine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine." [RESID:AA0350]
comment: This is a molecular function.
xref: RESID:AA0350
is_obsolete: true

[Term]
id: GO:0050742
name: obsolete protein-FMN linkage via S-(4a-FMN)-L-cysteine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine." [RESID:AA0351]
comment: This is a molecular function.
xref: RESID:AA0351
is_obsolete: true

[Term]
id: GO:0050743
name: obsolete protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352]
comment: This is a molecular function.
xref: RESID:AA0352
is_obsolete: true

[Term]
id: GO:0050744
name: obsolete protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine
namespace: biological_process
def: "OBSOLETE. The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine." [RESID:AA0353]
comment: This is a molecular function.
xref: RESID:AA0353
is_obsolete: true

[Term]
id: GO:0050745
name: obsolete peptide cross-linking via L-cysteinyl-5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
xref: RESID:AA0188
is_obsolete: true

[Term]
id: GO:0050746
name: regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]
synonym: "regulation of lipoprotein metabolism" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050747
name: positive regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]
synonym: "activation of lipoprotein metabolic process" NARROW []
synonym: "positive regulation of lipoprotein metabolism" EXACT []
synonym: "stimulation of lipoprotein metabolic process" NARROW []
synonym: "up regulation of lipoprotein metabolic process" EXACT []
synonym: "up-regulation of lipoprotein metabolic process" EXACT []
synonym: "upregulation of lipoprotein metabolic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050748
name: negative regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]
synonym: "down regulation of lipoprotein metabolic process" EXACT []
synonym: "down-regulation of lipoprotein metabolic process" EXACT []
synonym: "downregulation of lipoprotein metabolic process" EXACT []
synonym: "inhibition of lipoprotein metabolic process" NARROW []
synonym: "negative regulation of lipoprotein metabolism" EXACT []
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050749
name: obsolete apolipoprotein E receptor binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with an apolipoprotein E receptor." [GOC:ai]
comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
synonym: "apolipoprotein E receptor binding" EXACT []
is_obsolete: true
replaced_by: GO:0070326

[Term]
id: GO:0050750
name: low-density lipoprotein particle receptor binding
namespace: molecular_function
def: "Binding to a low-density lipoprotein receptor." [GOC:ai]
synonym: "LDL receptor binding" EXACT []
synonym: "low-density lipoprotein receptor binding" EXACT [GOC:dph]
is_a: GO:0070325 ! lipoprotein particle receptor binding

[Term]
id: GO:0050757
name: obsolete thymidylate synthase biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [GOC:curators]
comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'regulation of gene expression', 'regulation of transcription' or some signaling term.
synonym: "thymidylate synthase anabolism" EXACT []
synonym: "thymidylate synthase biosynthesis" EXACT []
synonym: "thymidylate synthase formation" EXACT []
synonym: "thymidylate synthase synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0050758
name: obsolete regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'regulation of gene expression', 'regulation of transcription' or some signaling term.
synonym: "regulation of thymidylate synthase anabolism" EXACT []
synonym: "regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "regulation of thymidylate synthase formation" EXACT []
synonym: "regulation of thymidylate synthase synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0050759
name: obsolete positive regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'positive regulation of gene expression', 'positive regulation of transcription' or some signaling term.
synonym: "activation of thymidylate synthase biosynthetic process" NARROW []
synonym: "positive regulation of thymidylate synthase anabolism" EXACT []
synonym: "positive regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "positive regulation of thymidylate synthase formation" EXACT []
synonym: "positive regulation of thymidylate synthase synthesis" EXACT []
synonym: "stimulation of thymidylate synthase biosynthetic process" NARROW []
synonym: "up regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "up-regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "upregulation of thymidylate synthase biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0050760
name: obsolete negative regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'negative regulation of gene expression', 'negative regulation of transcription' or some signaling term.
synonym: "down regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "down-regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "downregulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "inhibition of thymidylate synthase biosynthetic process" NARROW []
synonym: "negative regulation of thymidylate synthase anabolism" EXACT []
synonym: "negative regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "negative regulation of thymidylate synthase formation" EXACT []
synonym: "negative regulation of thymidylate synthase synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0050761
name: depsipeptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: goslim_pir
synonym: "depsipeptide metabolism" EXACT []
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0050762
name: depsipeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
synonym: "depsipeptide breakdown" EXACT []
synonym: "depsipeptide catabolism" EXACT []
synonym: "depsipeptide degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0050761 ! depsipeptide metabolic process

[Term]
id: GO:0050763
name: depsipeptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
synonym: "depsipeptide anabolism" EXACT []
synonym: "depsipeptide biosynthesis" EXACT []
synonym: "depsipeptide formation" EXACT []
synonym: "depsipeptide synthesis" EXACT []
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0050761 ! depsipeptide metabolic process

[Term]
id: GO:0050764
name: regulation of phagocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]
is_a: GO:0030100 ! regulation of endocytosis
relationship: regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050765
name: negative regulation of phagocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "down regulation of phagocytosis" EXACT []
synonym: "down-regulation of phagocytosis" EXACT []
synonym: "downregulation of phagocytosis" EXACT []
synonym: "inhibition of phagocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
relationship: negatively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050766
name: positive regulation of phagocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "activation of phagocytosis" NARROW []
synonym: "stimulation of phagocytosis" NARROW []
synonym: "up regulation of phagocytosis" EXACT []
synonym: "up-regulation of phagocytosis" EXACT []
synonym: "upregulation of phagocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
relationship: positively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050767
name: regulation of neurogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050768
name: negative regulation of neurogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai]
synonym: "down regulation of neurogenesis" EXACT []
synonym: "down-regulation of neurogenesis" EXACT []
synonym: "downregulation of neurogenesis" EXACT []
synonym: "inhibition of neurogenesis" NARROW []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051961 ! negative regulation of nervous system development
relationship: negatively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050769
name: positive regulation of neurogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai]
synonym: "activation of neurogenesis" NARROW []
synonym: "stimulation of neurogenesis" NARROW []
synonym: "up regulation of neurogenesis" EXACT []
synonym: "up-regulation of neurogenesis" EXACT []
synonym: "upregulation of neurogenesis" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051962 ! positive regulation of nervous system development
relationship: positively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050770
name: regulation of axonogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050771
name: negative regulation of axonogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "down regulation of axonogenesis" EXACT []
synonym: "down-regulation of axonogenesis" EXACT []
synonym: "downregulation of axonogenesis" EXACT []
synonym: "inhibition of axonogenesis" NARROW []
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:0050770 ! regulation of axonogenesis
relationship: negatively_regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050772
name: positive regulation of axonogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "activation of axonogenesis" NARROW []
synonym: "stimulation of axonogenesis" NARROW []
synonym: "up regulation of axonogenesis" EXACT []
synonym: "up-regulation of axonogenesis" EXACT []
synonym: "upregulation of axonogenesis" EXACT []
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:0050770 ! regulation of axonogenesis
relationship: positively_regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050773
name: regulation of dendrite development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0016358 ! dendrite development

[Term]
id: GO:0050774
name: negative regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "down regulation of dendrite morphogenesis" EXACT []
synonym: "down-regulation of dendrite morphogenesis" EXACT []
synonym: "downregulation of dendrite morphogenesis" EXACT []
synonym: "inhibition of dendrite morphogenesis" NARROW []
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
relationship: negatively_regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0050775
name: positive regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "activation of dendrite morphogenesis" NARROW []
synonym: "stimulation of dendrite morphogenesis" NARROW []
synonym: "up regulation of dendrite morphogenesis" EXACT []
synonym: "up-regulation of dendrite morphogenesis" EXACT []
synonym: "upregulation of dendrite morphogenesis" EXACT []
is_a: GO:0010770 ! positive regulation of cell morphogenesis
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
relationship: positively_regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0050776
name: regulation of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0006955 ! immune response

[Term]
id: GO:0050777
name: negative regulation of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "down regulation of immune response" EXACT []
synonym: "down-regulation of immune response" EXACT []
synonym: "downregulation of immune response" EXACT []
synonym: "inhibition of immune response" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
relationship: negatively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050778
name: positive regulation of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "stimulation of immune response" NARROW []
synonym: "up regulation of immune response" EXACT []
synonym: "up-regulation of immune response" EXACT []
synonym: "upregulation of immune response" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
relationship: positively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050779
name: RNA destabilization
namespace: biological_process
def: "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0043487 ! regulation of RNA stability
is_a: GO:0051254 ! positive regulation of RNA metabolic process
relationship: positively_regulates GO:0006401 ! RNA catabolic process

[Term]
id: GO:0050780
name: dopamine receptor binding
namespace: molecular_function
def: "Binding to a dopamine receptor." [GOC:ai]
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0050781
name: ortho-trichlorophenol reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029]
synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT []
synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0050782
name: galactose uniporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6]
synonym: "galactose, glucose uniporter activity" BROAD []
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0050783
name: cocaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732]
synonym: "cocaine metabolism" EXACT []
is_a: GO:0046448 ! tropane alkaloid metabolic process

[Term]
id: GO:0050784
name: cocaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [PMID:17132243]
synonym: "cocaine breakdown" EXACT []
synonym: "cocaine catabolism" EXACT []
synonym: "cocaine degradation" EXACT []
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0050783 ! cocaine metabolic process

[Term]
id: GO:0050785
name: advanced glycation end-product receptor activity
namespace: molecular_function
def: "Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)." [GOC:signaling, PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)]
synonym: "AGE receptor activity" EXACT [PMID:21590515]
synonym: "RAGE activity" EXACT [PMID:21590515]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0050786
name: RAGE receptor binding
namespace: molecular_function
def: "Binding to a RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai]
synonym: "advanced glycation end-product receptor binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0050787
name: detoxification of mercury ion
namespace: biological_process
def: "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0046689 ! response to mercury ion

[Term]
id: GO:0050788
name: obsolete sequestering of mercury
namespace: biological_process
def: "OBSOLETE. The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "mercuric ion (Hg2+) sequestering" EXACT []
synonym: "mercuric ion (Hg2+) sequestration" EXACT []
synonym: "mercury (Hg) ion sequestering" EXACT []
synonym: "mercury (Hg) ion sequestration" EXACT []
synonym: "mercury (Hg2+) ion retention" EXACT []
synonym: "mercury (Hg2+) ion storage" EXACT []
synonym: "retention of mercury (Hg2+) ion" EXACT []
synonym: "sequestering of mercuric ion (Hg2+)" EXACT []
synonym: "sequestering of mercury (Hg) ion" EXACT []
synonym: "sequestration of mercuric ion (Hg2+)" EXACT []
synonym: "sequestration of mercury (Hg) ion" EXACT []
synonym: "storage of mercury (Hg2+) ion" EXACT []
is_obsolete: true
consider: GO:0140487

[Term]
id: GO:0050789
name: regulation of biological process
namespace: biological_process
alt_id: GO:0050791
def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "regulation of physiological process" EXACT []
is_a: GO:0065007 ! biological regulation
relationship: regulates GO:0008150 ! biological_process

[Term]
id: GO:0050790
name: regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048552
def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]
subset: gocheck_obsoletion_candidate
subset: goslim_chembl
synonym: "regulation of enzyme activity" EXACT []
synonym: "regulation of metalloenzyme activity" NARROW []
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0050792
name: regulation of viral process
namespace: biological_process
def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb]
synonym: "regulation of viral reproduction" NARROW [GOC:bf, GOC:jl]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0016032 ! viral process

[Term]
id: GO:0050793
name: regulation of developmental process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0032502 ! developmental process

[Term]
id: GO:0050794
name: regulation of cellular process
namespace: biological_process
alt_id: GO:0051244
def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "regulation of cellular physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0009987 ! cellular process

[Term]
id: GO:0050795
name: regulation of behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]
synonym: "regulation of behaviour" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007610 ! behavior

[Term]
id: GO:0050796
name: regulation of insulin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0050797
name: thymidylate synthase (FAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+." [EC:2.1.1.148]
synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" RELATED [EC:2.1.1.148]
synonym: "FDTS activity" RELATED [EC:2.1.1.148]
synonym: "flavin dependent thymidylate synthase activity" RELATED [EC:2.1.1.148]
synonym: "Thy1 activity" EXACT []
synonym: "ThyX activity" EXACT []
xref: EC:2.1.1.148
xref: KEGG_REACTION:R06613
xref: MetaCyc:RXN-8850
xref: RHEA:29043
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0050798
name: activated T cell proliferation
namespace: biological_process
def: "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph]
comment: Note that this term refers to the proliferation of previously activated T cells; it is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells.
synonym: "activated T lymphocyte proliferation" EXACT []
synonym: "activated T-cell proliferation" EXACT []
synonym: "activated T-lymphocyte proliferation" EXACT []
synonym: "proliferation of activated T cells" EXACT [GOC:mah]
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0050799
name: cocaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai]
synonym: "cocaine anabolism" EXACT []
synonym: "cocaine biosynthesis" EXACT []
synonym: "cocaine formation" EXACT []
synonym: "cocaine synthesis" EXACT []
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:0050783 ! cocaine metabolic process

[Term]
id: GO:0050800
name: obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai]
comment: This term was made obsolete because it represents both process and function information.
synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0006810

[Term]
id: GO:0050801
name: monoatomic ion homeostasis
namespace: biological_process
alt_id: GO:2000021
def: "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai]
synonym: "electrolyte homeostasis" RELATED []
synonym: "ion homeostasis" BROAD []
synonym: "negative regulation of crystal formation" RELATED []
synonym: "regulation of ion homeostasis" RELATED []
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0050802
name: circadian sleep/wake cycle, sleep
namespace: biological_process
def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai]
is_a: GO:0022410 ! circadian sleep/wake cycle process
is_a: GO:0030431 ! sleep

[Term]
id: GO:0050803
name: regulation of synapse structure or activity
namespace: biological_process
def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0050804
name: modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]
subset: goslim_synapse
synonym: "modulation of synaptic transmission" BROAD []
synonym: "regulation of chemical synaptic transmission" EXACT []
synonym: "regulation of synaptic transmission" EXACT []
is_a: GO:0099177 ! regulation of trans-synaptic signaling
relationship: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0050805
name: negative regulation of synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "down regulation of synaptic transmission" EXACT []
synonym: "down-regulation of synaptic transmission" EXACT []
synonym: "downregulation of synaptic transmission" EXACT []
synonym: "inhibition of synaptic transmission" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: negatively_regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0050806
name: positive regulation of synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "activation of synaptic transmission" NARROW []
synonym: "stimulation of synaptic transmission" NARROW []
synonym: "up regulation of synaptic transmission" EXACT []
synonym: "up-regulation of synaptic transmission" EXACT []
synonym: "upregulation of synaptic transmission" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: positively_regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0050807
name: regulation of synapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of synapse organisation" EXACT [GOC:mah]
synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of synapse structure" EXACT []
is_a: GO:0051128 ! regulation of cellular component organization
relationship: part_of GO:0050803 ! regulation of synapse structure or activity
relationship: regulates GO:0050808 ! synapse organization

[Term]
id: GO:0050808
name: synapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
subset: goslim_drosophila
subset: goslim_synapse
synonym: "synapse development" RELATED [GOC:aruk]
synonym: "synapse morphogenesis" RELATED [GOC:BHF]
synonym: "synapse organisation" EXACT []
synonym: "synapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0050809
name: diazepam binding
namespace: molecular_function
def: "Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732]
synonym: "diazepam binding inhibitor activity" RELATED []
synonym: "Valium binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0050810
name: regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]
synonym: "regulation of steroid anabolism" EXACT []
synonym: "regulation of steroid biosynthesis" EXACT []
synonym: "regulation of steroid formation" EXACT []
synonym: "regulation of steroid synthesis" EXACT []
synonym: "regulation of steroidogenesis" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0050811
name: GABA receptor binding
namespace: molecular_function
def: "Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai]
synonym: "4-aminobutanoate receptor binding" EXACT []
synonym: "4-aminobutyrate receptor binding" EXACT []
synonym: "diazepam binding inhibitor activity" RELATED []
synonym: "gamma-aminobutyric acid receptor binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0050812
name: regulation of acyl-CoA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai]
synonym: "regulation of acyl-CoA anabolism" EXACT []
synonym: "regulation of acyl-CoA biosynthesis" EXACT []
synonym: "regulation of acyl-CoA formation" EXACT []
synonym: "regulation of acyl-CoA synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0050813
name: epothilone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [ISBN:0198506732]
synonym: "epothilone metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0033067 ! macrolide metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:0050814
name: epothilone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai]
synonym: "epothilone anabolism" EXACT []
synonym: "epothilone biosynthesis" EXACT []
synonym: "epothilone formation" EXACT []
synonym: "epothilone synthesis" EXACT []
is_a: GO:0033068 ! macrolide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0050813 ! epothilone metabolic process

[Term]
id: GO:0050815
name: phosphoserine residue binding
namespace: molecular_function
def: "Binding to a phosphorylated serine residue within a protein." [GOC:ai]
synonym: "phosphoserine binding" RELATED []
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0050816
name: phosphothreonine residue binding
namespace: molecular_function
def: "Binding to a phosphorylated threonine residue within a protein." [GOC:ai]
synonym: "phosphothreonine binding" RELATED []
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0050817
name: coagulation
namespace: biological_process
def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732]
subset: goslim_pir
synonym: "clotting" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050818
name: regulation of coagulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai]
synonym: "regulation of clotting" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0050817 ! coagulation

[Term]
id: GO:0050819
name: negative regulation of coagulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai]
synonym: "anticoagulant activity" RELATED []
synonym: "down regulation of coagulation" EXACT []
synonym: "down-regulation of coagulation" EXACT []
synonym: "downregulation of coagulation" EXACT []
synonym: "inhibition of coagulation" NARROW []
synonym: "negative regulation of clotting" EXACT []
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0050817 ! coagulation

[Term]
id: GO:0050820
name: positive regulation of coagulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai]
synonym: "activation of coagulation" NARROW []
synonym: "positive regulation of clotting" EXACT []
synonym: "stimulation of coagulation" NARROW []
synonym: "up regulation of coagulation" EXACT []
synonym: "up-regulation of coagulation" EXACT []
synonym: "upregulation of coagulation" EXACT []
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0050817 ! coagulation

[Term]
id: GO:0050821
name: protein stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
subset: goslim_chembl
synonym: "lysosomal protein stabilization" NARROW []
synonym: "positive regulation of protein stability" EXACT []
synonym: "protein sequestering" RELATED []
synonym: "protein stabilisation" EXACT [GOC:ah]
synonym: "protein stabilization activity" RELATED []
is_a: GO:0031647 ! regulation of protein stability

[Term]
id: GO:0050822
name: peptide stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai]
synonym: "peptide stabilisation" EXACT [GOC:ah]
synonym: "peptide stabilization activity" RELATED []
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0050823
name: peptide antigen stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai]
synonym: "peptide antigen stabilization activity" RELATED []
is_a: GO:0050822 ! peptide stabilization
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0050824
name: obsolete water binding
namespace: molecular_function
def: "OBSOLETE. Binding to water (H2O)." [GOC:ai]
comment: This term was obsoleted because water binding is non-specific.
is_obsolete: true

[Term]
id: GO:0050825
name: ice binding
namespace: molecular_function
def: "Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators]
synonym: "ice crystal binding" EXACT []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0050826
name: response to freezing
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl]
synonym: "antifreeze activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0050829
name: defense response to Gram-negative bacterium
namespace: biological_process
def: "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to Gram-negative bacteria" EXACT []
synonym: "defence response to Gram-negative bacterium" EXACT []
synonym: "defense response to Gram-negative bacteria" EXACT []
synonym: "Gram-negative antibacterial peptide activity" RELATED []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050830
name: defense response to Gram-positive bacterium
namespace: biological_process
def: "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to Gram-positive bacteria" EXACT []
synonym: "defence response to Gram-positive bacterium" EXACT []
synonym: "defense response to Gram-positive bacteria" EXACT []
synonym: "Gram-positive antibacterial peptide activity" RELATED []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050831
name: male-specific defense response to bacterium
namespace: biological_process
def: "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai]
synonym: "male-specific antibacterial peptide activity" RELATED []
synonym: "male-specific defence response to bacteria" EXACT []
synonym: "male-specific defence response to bacterium" EXACT []
synonym: "male-specific defense response to bacteria" EXACT []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050832
name: defense response to fungus
namespace: biological_process
alt_id: GO:0009623
alt_id: GO:0009817
alt_id: GO:0042831
def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to fungi" EXACT []
synonym: "defence response to fungus" EXACT []
synonym: "defense response to fungi" EXACT []
synonym: "defense response to fungus, incompatible interaction" NARROW []
synonym: "resistance response to pathogenic fungi" NARROW []
synonym: "resistance response to pathogenic fungus" NARROW []
synonym: "response to parasitic fungi" NARROW []
synonym: "response to parasitic fungus" NARROW []
is_a: GO:0009620 ! response to fungus
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0050833
name: pyruvate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other." [GOC:ai]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
xref: Reactome:R-HSA-372342 "MPC1:MPC2 imports PYR, H+ to mitochondrial matrix"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0050834
name: obsolete molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def: "OBSOLETE. The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050835
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050836
name: obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050837
name: obsolete peptide cross-linking via L-cysteinyl-L-selenocysteine
namespace: biological_process
def: "OBSOLETE. The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process.
xref: RESID:AA0358
is_obsolete: true

[Term]
id: GO:0050838
name: obsolete peptidyl-5-hydroxy-L-lysine trimethylation
namespace: biological_process
def: "OBSOLETE. The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050839
name: cell adhesion molecule binding
namespace: molecular_function
def: "Binding to a cell adhesion molecule." [GOC:ai]
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "CAM binding" EXACT []
synonym: "cell adhesion molecule activity" RELATED []
synonym: "cell adhesion receptor activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0050840
name: extracellular matrix binding
namespace: molecular_function
def: "Binding to a component of the extracellular matrix." [GOC:ai]
subset: goslim_chembl
subset: goslim_pir
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "extracellular matrix constituent binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0050841
name: obsolete peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl trimethyl lysine hydroxylase activity" EXACT []
synonym: "peptidyl-trimethyl-lysine hydroxylase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0050842
name: obsolete copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def: "OBSOLETE. The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050843
name: S-adenosylmethionine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]
synonym: "S-adenosyl methionine catabolic process" EXACT []
synonym: "S-adenosyl methionine catabolism" EXACT []
synonym: "S-adenosylmethionine breakdown" EXACT []
synonym: "S-adenosylmethionine catabolism" EXACT []
synonym: "S-adenosylmethionine degradation" EXACT []
synonym: "SAM catabolic process" EXACT []
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process

[Term]
id: GO:0050844
name: peptidyl-selenocysteine modification
namespace: biological_process
def: "The modification of peptidyl-selenocysteine." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0050845
name: teichuronic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]
synonym: "teichuronic acid anabolism" EXACT []
synonym: "teichuronic acid biosynthesis" EXACT []
synonym: "teichuronic acid formation" EXACT []
synonym: "teichuronic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0050846 ! teichuronic acid metabolic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0050846
name: teichuronic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]
synonym: "teichuronic acid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process

[Term]
id: GO:0050847
name: progesterone receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by a progesterone binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:14744870]
synonym: "intracellular progesterone receptor signaling pathway" EXACT []
synonym: "nuclear receptor-mediated progesterone signaling pathway" EXACT []
synonym: "progesterone receptor signalling pathway" EXACT []
is_a: GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0050848
name: regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai]
synonym: "regulation of calcium-mediated signalling" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050849
name: negative regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592]
synonym: "down regulation of calcium-mediated signaling" EXACT []
synonym: "down-regulation of calcium-mediated signaling" EXACT []
synonym: "downregulation of calcium-mediated signaling" EXACT []
synonym: "inhibition of calcium-mediated signaling" NARROW []
synonym: "negative regulation of calcium-mediated signalling" EXACT []
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050850
name: positive regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai]
synonym: "activation of calcium-mediated signaling" NARROW []
synonym: "positive regulation of calcium-mediated signalling" EXACT []
synonym: "stimulation of calcium-mediated signaling" NARROW []
synonym: "up regulation of calcium-mediated signaling" EXACT []
synonym: "up-regulation of calcium-mediated signaling" EXACT []
synonym: "upregulation of calcium-mediated signaling" EXACT []
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050851
name: antigen receptor-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add]
synonym: "antigen receptor-mediated signalling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0050852
name: T cell receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add]
synonym: "T lymphocyte receptor signaling pathway" EXACT []
synonym: "T lymphocyte receptor signalling pathway" EXACT []
synonym: "T-cell receptor signaling pathway" EXACT []
synonym: "T-cell receptor signalling pathway" EXACT []
synonym: "T-lymphocyte receptor signaling pathway" EXACT []
synonym: "T-lymphocyte receptor signalling pathway" EXACT []
synonym: "TCR signaling pathway" EXACT []
is_a: GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050853
name: B cell receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add]
synonym: "B cell receptor signalling pathway" EXACT []
synonym: "B lymphocyte receptor signaling pathway" EXACT []
synonym: "B lymphocyte receptor signalling pathway" EXACT []
synonym: "B-cell receptor signaling pathway" EXACT []
synonym: "B-cell receptor signalling pathway" EXACT []
synonym: "B-lymphocyte receptor signaling pathway" EXACT []
synonym: "B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050854
name: regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "regulation of antigen receptor mediated signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050855
name: regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "regulation of B cell receptor signalling pathway" EXACT []
synonym: "regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of B-cell receptor signaling pathway" EXACT []
synonym: "regulation of B-cell receptor signalling pathway" EXACT []
synonym: "regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050856
name: regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of T-cell receptor signaling pathway" EXACT []
synonym: "regulation of T-cell receptor signalling pathway" EXACT []
synonym: "regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of TCR signaling pathway" EXACT []
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050857
name: positive regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "activation of antigen receptor-mediated signaling pathway" NARROW []
synonym: "positive regulation of antigen receptor mediated signalling pathway" EXACT []
synonym: "stimulation of antigen receptor-mediated signaling pathway" NARROW []
synonym: "up regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "up-regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "upregulation of antigen receptor-mediated signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050858
name: negative regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "down regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "down-regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "downregulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "inhibition of antigen receptor-mediated signaling pathway" NARROW []
synonym: "negative regulation of antigen receptor mediated signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050859
name: negative regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "down regulation of B cell receptor signaling pathway" EXACT []
synonym: "down-regulation of B cell receptor signaling pathway" EXACT []
synonym: "downregulation of B cell receptor signaling pathway" EXACT []
synonym: "inhibition of B cell receptor signaling pathway" NARROW []
synonym: "negative regulation of B cell receptor signalling pathway" EXACT []
synonym: "negative regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of B-cell receptor signaling pathway" EXACT []
synonym: "negative regulation of B-cell receptor signalling pathway" EXACT []
synonym: "negative regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050855 ! regulation of B cell receptor signaling pathway
is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway
relationship: negatively_regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050860
name: negative regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "down regulation of T cell receptor signaling pathway" EXACT []
synonym: "down-regulation of T cell receptor signaling pathway" EXACT []
synonym: "downregulation of T cell receptor signaling pathway" EXACT []
synonym: "inhibition of T cell receptor signaling pathway" NARROW []
synonym: "negative regulation of T cell receptor signalling pathway" EXACT []
synonym: "negative regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of T-cell receptor signaling pathway" EXACT []
synonym: "negative regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of TCR signaling pathway" EXACT []
is_a: GO:0050856 ! regulation of T cell receptor signaling pathway
is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway
relationship: negatively_regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050861
name: positive regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "activation of B cell receptor signaling pathway" NARROW []
synonym: "positive regulation of B cell receptor signalling pathway" EXACT []
synonym: "positive regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of B-cell receptor signaling pathway" EXACT []
synonym: "positive regulation of B-cell receptor signalling pathway" EXACT []
synonym: "positive regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of B-lymphocyte receptor signalling pathway" EXACT []
synonym: "stimulation of B cell receptor signaling pathway" NARROW []
synonym: "up regulation of B cell receptor signaling pathway" EXACT []
synonym: "up-regulation of B cell receptor signaling pathway" EXACT []
synonym: "upregulation of B cell receptor signaling pathway" EXACT []
is_a: GO:0050855 ! regulation of B cell receptor signaling pathway
is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway
relationship: positively_regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050862
name: positive regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "activation of T cell receptor signaling pathway" NARROW []
synonym: "positive regulation of T cell receptor signalling pathway" EXACT []
synonym: "positive regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of T-cell receptor signaling pathway" EXACT []
synonym: "positive regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of TCR signaling pathway" EXACT []
synonym: "stimulation of T cell receptor signaling pathway" NARROW []
synonym: "up regulation of T cell receptor signaling pathway" EXACT []
synonym: "up-regulation of T cell receptor signaling pathway" EXACT []
synonym: "upregulation of T cell receptor signaling pathway" EXACT []
is_a: GO:0050856 ! regulation of T cell receptor signaling pathway
is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway
relationship: positively_regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050863
name: regulation of T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "regulation of T lymphocyte activation" EXACT []
synonym: "regulation of T-cell activation" EXACT []
synonym: "regulation of T-lymphocyte activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050864
name: regulation of B cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "regulation of B lymphocyte activation" EXACT []
synonym: "regulation of B-cell activation" EXACT []
synonym: "regulation of B-lymphocyte activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050865
name: regulation of cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001775 ! cell activation

[Term]
id: GO:0050866
name: negative regulation of cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai]
synonym: "down regulation of cell activation" EXACT []
synonym: "down-regulation of cell activation" EXACT []
synonym: "downregulation of cell activation" EXACT []
synonym: "inhibition of cell activation" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050867
name: positive regulation of cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai]
synonym: "activation of cell activation" NARROW []
synonym: "stimulation of cell activation" NARROW []
synonym: "up regulation of cell activation" EXACT []
synonym: "up-regulation of cell activation" EXACT []
synonym: "upregulation of cell activation" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050868
name: negative regulation of T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "down regulation of T cell activation" EXACT []
synonym: "down-regulation of T cell activation" EXACT []
synonym: "downregulation of T cell activation" EXACT []
synonym: "inhibition of T cell activation" NARROW []
synonym: "negative regulation of T lymphocyte activation" EXACT []
synonym: "negative regulation of T-cell activation" EXACT []
synonym: "negative regulation of T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
relationship: negatively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050869
name: negative regulation of B cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "down regulation of B cell activation" EXACT []
synonym: "down-regulation of B cell activation" EXACT []
synonym: "downregulation of B cell activation" EXACT []
synonym: "inhibition of B cell activation" NARROW []
synonym: "negative regulation of B lymphocyte activation" EXACT []
synonym: "negative regulation of B-cell activation" EXACT []
synonym: "negative regulation of B-lymphocyte activation" EXACT []
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050870
name: positive regulation of T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "activation of T cell activation" NARROW []
synonym: "positive regulation of T lymphocyte activation" EXACT []
synonym: "positive regulation of T-cell activation" EXACT []
synonym: "positive regulation of T-lymphocyte activation" EXACT []
synonym: "stimulation of T cell activation" NARROW []
synonym: "up regulation of T cell activation" EXACT []
synonym: "up-regulation of T cell activation" EXACT []
synonym: "upregulation of T cell activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
relationship: positively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050871
name: positive regulation of B cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "activation of B cell activation" NARROW []
synonym: "positive regulation of B lymphocyte activation" EXACT []
synonym: "positive regulation of B-cell activation" EXACT []
synonym: "positive regulation of B-lymphocyte activation" EXACT []
synonym: "stimulation of B cell activation" NARROW []
synonym: "up regulation of B cell activation" EXACT []
synonym: "up-regulation of B cell activation" EXACT []
synonym: "upregulation of B cell activation" EXACT []
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050872
name: white fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945]
synonym: "white adipocyte cell differentiation" EXACT []
synonym: "white adipocyte differentiation" EXACT []
is_a: GO:0045444 ! fat cell differentiation

[Term]
id: GO:0050873
name: brown fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810]
synonym: "brown adipocyte cell differentiation" EXACT []
synonym: "brown adipocyte differentiation" EXACT []
is_a: GO:0045444 ! fat cell differentiation

[Term]
id: GO:0050877
name: nervous system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_pir
synonym: "neurological system process" EXACT []
synonym: "neurophysiological process" EXACT []
synonym: "pan-neural process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050878
name: regulation of body fluid levels
namespace: biological_process
def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_pir
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0050879
name: multicellular organismal movement
namespace: biological_process
def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050881
name: musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph]
is_a: GO:0050879 ! multicellular organismal movement
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050882
name: voluntary musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph]
is_a: GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0050883
name: musculoskeletal movement, spinal reflex action
namespace: biological_process
def: "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph]
is_a: GO:0050881 ! musculoskeletal movement
is_a: GO:0060004 ! reflex

[Term]
id: GO:0050884
name: neuromuscular process controlling posture
namespace: biological_process
def: "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb]
synonym: "regulation of posture" EXACT []
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050885
name: neuromuscular process controlling balance
namespace: biological_process
def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph]
synonym: "regulation of balance" RELATED []
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050886
name: endocrine process
namespace: biological_process
def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544]
subset: goslim_generic
subset: goslim_pir
synonym: "endocrine physiological process" EXACT []
synonym: "endocrine physiology" EXACT []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050887
name: determination of sensory modality
namespace: biological_process
def: "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050888
name: determination of stimulus location
namespace: biological_process
def: "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050889
name: determination of stimulus intensity
namespace: biological_process
def: "The determination of the perceived strength of a sensory stimulus." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050890
name: cognition
namespace: biological_process
def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908]
subset: goslim_drosophila
xref: Wikipedia:Cognition
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0050891
name: multicellular organismal-level water homeostasis
namespace: biological_process
def: "A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:dph, GOC:tb]
synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb]
synonym: "multicellular organismal water homeostasis" EXACT []
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0140962 ! multicellular organismal-level chemical homeostasis

[Term]
id: GO:0050892
name: intestinal absorption
namespace: biological_process
def: "A process in which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph]
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0050893
name: sensory processing
namespace: biological_process
def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544]
is_a: GO:0050890 ! cognition
relationship: part_of GO:0007600 ! sensory perception

[Term]
id: GO:0050894
name: determination of affect
namespace: biological_process
def: "Any process in which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050896
name: response to stimulus
namespace: biological_process
alt_id: GO:0051869
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "physiological response to stimulus" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0050897
name: cobalt ion binding
namespace: molecular_function
def: "Binding to a cobalt ion (Co2+)." [GOC:ai]
synonym: "Co ion binding" EXACT []
synonym: "cobalt binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0050898
name: nitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [PMID:18987211]
synonym: "nitrile metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0050899
name: nitrile catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544]
synonym: "nitrile breakdown" EXACT []
synonym: "nitrile catabolism" EXACT []
synonym: "nitrile degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0050900
name: leukocyte migration
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration" EXACT []
synonym: "immune cell trafficking" EXACT []
synonym: "leucocyte migration" EXACT []
synonym: "leucocyte trafficking" EXACT []
synonym: "leukocyte trafficking" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0050901
name: leukocyte tethering or rolling
namespace: biological_process
def: "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection)." [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050902
name: leukocyte adhesive activation
namespace: biological_process
def: "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "leukocyte adhesive triggering" EXACT []
is_a: GO:0045321 ! leukocyte activation
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050903
name: leukocyte activation-dependent arrest
namespace: biological_process
def: "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050904
name: diapedesis
namespace: biological_process
def: "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
comment: Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic.
is_a: GO:0050900 ! leukocyte migration
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050905
name: neuromuscular process
namespace: biological_process
def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]
synonym: "neuromotor process" EXACT []
synonym: "neuromuscular physiological process" EXACT []
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0050906
name: detection of stimulus involved in sensory perception
namespace: biological_process
def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]
synonym: "sensory detection of stimulus" EXACT []
synonym: "sensory perception, sensory transduction of stimulus" EXACT []
synonym: "sensory perception, stimulus detection" EXACT []
synonym: "sensory transduction" EXACT []
xref: Wikipedia:Transduction_(physiology)
is_a: GO:0051606 ! detection of stimulus
relationship: part_of GO:0007600 ! sensory perception

[Term]
id: GO:0050907
name: detection of chemical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of chemical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050908
name: detection of light stimulus involved in visual perception
namespace: biological_process
def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "sensory detection of light during visual perception" EXACT []
synonym: "sensory detection of light stimulus during visual perception" EXACT []
synonym: "sensory transduction of light during visual perception" EXACT []
synonym: "sensory transduction of light stimulus during visual perception" EXACT []
synonym: "visual perception, detection of light stimulus" EXACT []
synonym: "visual perception, sensory transduction during perception of light" EXACT []
synonym: "visual perception, sensory transduction of light stimulus" EXACT []
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: part_of GO:0007601 ! visual perception

[Term]
id: GO:0050909
name: sensory perception of taste
namespace: biological_process
def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai]
synonym: "gustation" EXACT []
synonym: "sense of taste" EXACT []
synonym: "taste" EXACT []
synonym: "taste perception" EXACT []
xref: Wikipedia:Taste
is_a: GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050910
name: detection of mechanical stimulus involved in sensory perception of sound
namespace: biological_process
alt_id: GO:0009592
alt_id: GO:0055128
def: "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." [GOC:ai]
synonym: "detection of sound" EXACT []
synonym: "hearing, sensory transduction of sound" EXACT []
synonym: "perception of sound, detection of mechanical stimulus" EXACT []
synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT []
synonym: "sensory transduction of sound" EXACT []
is_a: GO:0050877 ! nervous system process
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0007605 ! sensory perception of sound

[Term]
id: GO:0050911
name: detection of chemical stimulus involved in sensory perception of smell
namespace: biological_process
def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "perception of smell, detection of chemical stimulus" EXACT []
synonym: "perception of smell, sensory detection of chemical stimulus" EXACT []
synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of smell" EXACT []
synonym: "sensory detection of scent" EXACT []
synonym: "sensory detection of smell" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT []
synonym: "sensory transduction of scent" EXACT []
synonym: "sensory transduction of smell" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: part_of GO:0007608 ! sensory perception of smell

[Term]
id: GO:0050912
name: detection of chemical stimulus involved in sensory perception of taste
namespace: biological_process
def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "perception of taste, detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of taste" EXACT []
synonym: "sensory detection of taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT []
synonym: "sensory transduction of taste" EXACT []
synonym: "taste perception" BROAD []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: part_of GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050913
name: sensory perception of bitter taste
namespace: biological_process
def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "bitter taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050914
name: sensory perception of salty taste
namespace: biological_process
def: "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "salty taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050915
name: sensory perception of sour taste
namespace: biological_process
def: "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sour taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050916
name: sensory perception of sweet taste
namespace: biological_process
def: "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sweet taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050917
name: sensory perception of umami taste
namespace: biological_process
def: "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process." [GOC:ai]
synonym: "umami taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050918
name: positive chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
synonym: "chemoattraction" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0050919
name: negative chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
synonym: "chemoaversion" EXACT []
synonym: "chemorepulsion" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0050920
name: regulation of chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0040012 ! regulation of locomotion
relationship: regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050921
name: positive regulation of chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
synonym: "activation of chemotaxis" NARROW []
synonym: "stimulation of chemotaxis" NARROW []
synonym: "up regulation of chemotaxis" EXACT []
synonym: "up-regulation of chemotaxis" EXACT []
synonym: "upregulation of chemotaxis" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0050920 ! regulation of chemotaxis
relationship: positively_regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050922
name: negative regulation of chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
synonym: "down regulation of chemotaxis" EXACT []
synonym: "down-regulation of chemotaxis" EXACT []
synonym: "downregulation of chemotaxis" EXACT []
synonym: "inhibition of chemotaxis" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0050920 ! regulation of chemotaxis
relationship: negatively_regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050923
name: regulation of negative chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050924
name: positive regulation of negative chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "activation of negative chemotaxis" NARROW []
synonym: "stimulation of negative chemotaxis" NARROW []
synonym: "up regulation of negative chemotaxis" EXACT []
synonym: "up-regulation of negative chemotaxis" EXACT []
synonym: "upregulation of negative chemotaxis" EXACT []
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0050923 ! regulation of negative chemotaxis
relationship: positively_regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050925
name: negative regulation of negative chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "down regulation of negative chemotaxis" EXACT []
synonym: "down-regulation of negative chemotaxis" EXACT []
synonym: "downregulation of negative chemotaxis" EXACT []
synonym: "inhibition of negative chemotaxis" NARROW []
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0050923 ! regulation of negative chemotaxis
relationship: negatively_regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050926
name: regulation of positive chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050927
name: positive regulation of positive chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "activation of positive chemotaxis" NARROW []
synonym: "stimulation of positive chemotaxis" NARROW []
synonym: "up regulation of positive chemotaxis" EXACT []
synonym: "up-regulation of positive chemotaxis" EXACT []
synonym: "upregulation of positive chemotaxis" EXACT []
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0050926 ! regulation of positive chemotaxis
relationship: positively_regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050928
name: negative regulation of positive chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "down regulation of positive chemotaxis" EXACT []
synonym: "down-regulation of positive chemotaxis" EXACT []
synonym: "downregulation of positive chemotaxis" EXACT []
synonym: "inhibition of positive chemotaxis" NARROW []
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0050926 ! regulation of positive chemotaxis
relationship: negatively_regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050929
name: induction of negative chemotaxis
namespace: biological_process
def: "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050924 ! positive regulation of negative chemotaxis

[Term]
id: GO:0050930
name: induction of positive chemotaxis
namespace: biological_process
def: "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050927 ! positive regulation of positive chemotaxis

[Term]
id: GO:0050931
name: pigment cell differentiation
namespace: biological_process
alt_id: GO:0043357
alt_id: GO:0043358
def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh]
comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.
synonym: "chromatophore differentiation" EXACT []
synonym: "pigmented cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048066 ! developmental pigmentation

[Term]
id: GO:0050932
name: regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050933
name: early stripe melanocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836]
synonym: "early stripe melanocyte cell differentiation" EXACT []
synonym: "early stripe melanophore differentiation" EXACT []
is_a: GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0050934
name: late stripe melanocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836]
synonym: "late stripe melanocyte cell differentiation" EXACT []
synonym: "late stripe melanophore differentiation" EXACT []
is_a: GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0050935
name: iridophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jid, GOC:mh, PMID:11858836]
synonym: "iridophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050936
name: xanthophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jid, GOC:mh, PMID:11858836]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "xanthophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050937
name: regulation of iridophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050938
name: regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050939
name: regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "regulation of early stripe melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
relationship: regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050940
name: regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "regulation of late stripe melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
relationship: regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050941
name: negative regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "down regulation of pigment cell differentiation" EXACT []
synonym: "down-regulation of pigment cell differentiation" EXACT []
synonym: "downregulation of pigment cell differentiation" EXACT []
synonym: "inhibition of pigment cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: negatively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050942
name: positive regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "activation of pigment cell differentiation" NARROW []
synonym: "stimulation of pigment cell differentiation" NARROW []
synonym: "up regulation of pigment cell differentiation" EXACT []
synonym: "up-regulation of pigment cell differentiation" EXACT []
synonym: "upregulation of pigment cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: positively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050943
name: negative regulation of iridophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai]
synonym: "down regulation of iridophore differentiation" EXACT []
synonym: "down-regulation of iridophore differentiation" EXACT []
synonym: "downregulation of iridophore differentiation" EXACT []
synonym: "inhibition of iridophore differentiation" NARROW []
is_a: GO:0050937 ! regulation of iridophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050944
name: negative regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "down regulation of xanthophore differentiation" EXACT []
synonym: "down-regulation of xanthophore differentiation" EXACT []
synonym: "downregulation of xanthophore differentiation" EXACT []
synonym: "inhibition of xanthophore differentiation" NARROW []
is_a: GO:0050938 ! regulation of xanthophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050945
name: positive regulation of iridophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai]
synonym: "activation of iridophore differentiation" NARROW []
synonym: "stimulation of iridophore differentiation" NARROW []
synonym: "up regulation of iridophore differentiation" EXACT []
synonym: "up-regulation of iridophore differentiation" EXACT []
synonym: "upregulation of iridophore differentiation" EXACT []
is_a: GO:0050937 ! regulation of iridophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050946
name: positive regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "activation of xanthophore differentiation" NARROW []
synonym: "stimulation of xanthophore differentiation" NARROW []
synonym: "up regulation of xanthophore differentiation" EXACT []
synonym: "up-regulation of xanthophore differentiation" EXACT []
synonym: "upregulation of xanthophore differentiation" EXACT []
is_a: GO:0050938 ! regulation of xanthophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050947
name: negative regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "down regulation of early stripe melanocyte differentiation" EXACT []
synonym: "down-regulation of early stripe melanocyte differentiation" EXACT []
synonym: "downregulation of early stripe melanocyte differentiation" EXACT []
synonym: "inhibition of early stripe melanocyte differentiation" NARROW []
synonym: "negative regulation of early stripe melanophore differentiation" EXACT []
is_a: GO:0045635 ! negative regulation of melanocyte differentiation
is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation
relationship: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050948
name: positive regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "activation of early stripe melanocyte differentiation" NARROW []
synonym: "positive regulation of early stripe melanophore differentiation" EXACT []
synonym: "stimulation of early stripe melanocyte differentiation" NARROW []
synonym: "up regulation of early stripe melanocyte differentiation" EXACT []
synonym: "up-regulation of early stripe melanocyte differentiation" EXACT []
synonym: "upregulation of early stripe melanocyte differentiation" EXACT []
is_a: GO:0045636 ! positive regulation of melanocyte differentiation
is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation
relationship: positively_regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050949
name: negative regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "down regulation of late stripe melanocyte differentiation" EXACT []
synonym: "down-regulation of late stripe melanocyte differentiation" EXACT []
synonym: "downregulation of late stripe melanocyte differentiation" EXACT []
synonym: "inhibition of late stripe melanocyte differentiation" NARROW []
synonym: "negative regulation of late stripe melanophore differentiation" EXACT []
is_a: GO:0045635 ! negative regulation of melanocyte differentiation
is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation
relationship: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050950
name: positive regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "activation of late stripe melanocyte differentiation" NARROW []
synonym: "positive regulation of late stripe melanophore differentiation" EXACT []
synonym: "stimulation of late stripe melanocyte differentiation" NARROW []
synonym: "up regulation of late stripe melanocyte differentiation" EXACT []
synonym: "up-regulation of late stripe melanocyte differentiation" EXACT []
synonym: "upregulation of late stripe melanocyte differentiation" EXACT []
is_a: GO:0045636 ! positive regulation of melanocyte differentiation
is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation
relationship: positively_regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050951
name: sensory perception of temperature stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sensory perception of thermal stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050952
name: sensory perception of electrical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050953
name: sensory perception of light stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050954
name: sensory perception of mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanosensory perception" EXACT []
synonym: "perception of mechanical stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050955
name: thermoception
namespace: biological_process
def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, Wikipedia:Thermoception]
synonym: "thermoreception" EXACT []
xref: Wikipedia:Thermoception
is_a: GO:0050951 ! sensory perception of temperature stimulus

[Term]
id: GO:0050956
name: electroception
namespace: biological_process
def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception]
synonym: "electroception sense" EXACT []
synonym: "electroceptive sense" EXACT []
xref: Wikipedia:Electroreception
is_a: GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050957
name: equilibrioception
namespace: biological_process
def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [PMID:29303967]
synonym: "sensory perception of orientation with respect to gravity" EXACT []
xref: Wikipedia:Equilibrioception
is_a: GO:0007600 ! sensory perception
relationship: part_of GO:0050885 ! neuromuscular process controlling balance

[Term]
id: GO:0050958
name: magnetoreception
namespace: biological_process
def: "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoception" EXACT []
synonym: "sensory perception of magnetic field" EXACT []
xref: Wikipedia:Magnetoception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050959
name: echolocation
namespace: biological_process
def: "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [PMID:16005275, Wikipedia:Animal_echolocation]
synonym: "biological sonar" EXACT [https://en.wikipedia.org/wiki/Animal_echolocation]
synonym: "perception of environment using reflected sound waves" EXACT []
xref: Wikipedia:Echolocation
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0050960
name: detection of temperature stimulus involved in thermoception
namespace: biological_process
def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos]
synonym: "sensory detection of temperature stimulus during thermoception" EXACT []
synonym: "sensory detection of thermal stimulus during thermoception" EXACT []
synonym: "sensory transduction of temperature stimulus during thermoception" EXACT []
synonym: "sensory transduction of thermal stimulus during thermoception" EXACT []
synonym: "thermoception, sensory detection of temperature stimulus" EXACT []
synonym: "thermoception, sensory detection of thermal stimulus" EXACT []
synonym: "thermoception, sensory transduction of temperature stimulus" EXACT []
synonym: "thermoception, sensory transduction of thermal stimulus" EXACT []
is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception
relationship: part_of GO:0050955 ! thermoception

[Term]
id: GO:0050961
name: detection of temperature stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of heat stimulus during sensory perception" NARROW []
synonym: "sensory detection of temperature stimulus" EXACT []
synonym: "sensory detection of temperature stimulus during sensory perception" EXACT []
synonym: "sensory detection of thermal stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of heat stimulus" NARROW []
synonym: "sensory perception, sensory detection of temperature stimulus" EXACT []
synonym: "sensory perception, sensory detection of thermal stimulus" EXACT []
synonym: "sensory perception, sensory transduction of heat stimulus" NARROW []
synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT []
synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT []
synonym: "sensory transduction of heat stimulus during sensory perception" NARROW []
synonym: "sensory transduction of temperature stimulus" EXACT []
synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT []
synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT []
is_a: GO:0016048 ! detection of temperature stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of GO:0050951 ! sensory perception of temperature stimulus

[Term]
id: GO:0050962
name: detection of light stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos]
synonym: "sensory detection of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of light stimulus" EXACT []
synonym: "sensory perception, sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus during sensory perception" EXACT []
is_a: GO:0009583 ! detection of light stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0050963
name: detection of electrical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of electrical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT []
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050981 ! detection of electrical stimulus
relationship: part_of GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050964
name: detection of electrical stimulus involved in electroception
namespace: biological_process
def: "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb]
synonym: "electroception, detection of electrical stimulus" EXACT []
synonym: "electroception, sensory detection of electrical stimulus" EXACT []
synonym: "electroception, sensory transduction" EXACT []
synonym: "electroception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during electroception" RELATED []
synonym: "sensory transduction of electrical stimulus during electroception" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
relationship: part_of GO:0050956 ! electroception

[Term]
id: GO:0050965
name: detection of temperature stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "perception of pain, detection of temperature stimulus" EXACT []
synonym: "perception of pain, sensory detection of temperature stimulus" EXACT []
synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT []
synonym: "sensory detection of temperature stimulus during perception of pain" EXACT []
synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT []
synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT []
synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT []
synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT []
synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT []
synonym: "thermal nociception" RELATED [GOC:pr]
is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception
is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain

[Term]
id: GO:0050966
name: detection of mechanical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "mechanical nociception" RELATED [GOC:pr]
synonym: "perception of pain, detection of mechanical stimulus" EXACT []
synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain

[Term]
id: GO:0050967
name: detection of electrical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb]
synonym: "perception of pain, detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during perception of pain" RELATED []
synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain

[Term]
id: GO:0050968
name: detection of chemical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "chemical nociception" RELATED [GOC:pr]
synonym: "perception of pain, detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain

[Term]
id: GO:0050969
name: detection of chemical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai, GOC:dos]
synonym: "magnetoception, sensory transduction of chemical stimulus" EXACT []
synonym: "magnetoreception, detection of chemical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of chemical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of chemical stimulus during magnetoreception" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: part_of GO:0050977 ! magnetoreception by sensory perception of chemical stimulus

[Term]
id: GO:0050970
name: detection of electrical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, GOC:dos, GOC:dph, GOC:tb, PMID:15886990, Wikipedia:Magnetoception]
synonym: "detection of electrical stimulus during magnetoreception" RELATED [GOC:dph, GOC:tb]
synonym: "magnetoception, sensory transduction of electrical stimulus" EXACT []
synonym: "magnetoreception, detection of electrical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of electrical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during magnetoreception" RELATED []
synonym: "sensory transduction of electrical stimulus during magnetoreception" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
relationship: part_of GO:0050978 ! magnetoreception by sensory perception of electrical stimulus

[Term]
id: GO:0050971
name: detection of mechanical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai, GOC:dos]
synonym: "magnetoception, sensory transduction of mechanical stimulus" EXACT []
synonym: "magnetoreception, detection of mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of mechanical stimulus during magnetoreception" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050979 ! magnetoreception by sensory perception of mechanical stimulus

[Term]
id: GO:0050972
name: detection of mechanical stimulus involved in echolocation
namespace: biological_process
def: "The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai, GOC:dos]
synonym: "echolocation, detection of mechanical stimulus" EXACT []
synonym: "echolocation, sensory detection of mechanical stimulus" EXACT []
synonym: "echolocation, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during echolocation" EXACT []
synonym: "sensory transduction of mechanical stimulus during echolocation" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050959 ! echolocation

[Term]
id: GO:0050973
name: detection of mechanical stimulus involved in equilibrioception
namespace: biological_process
def: "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai, GOC:dos]
synonym: "equilibrioception, detection of mechanical stimulus" EXACT []
synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT []
synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT []
synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0050974
name: detection of mechanical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT []
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050975
name: sensory perception of touch
namespace: biological_process
def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
synonym: "perception of touch" EXACT []
synonym: "tactile sense" EXACT []
synonym: "taction" EXACT []
synonym: "tactition" EXACT []
xref: Wikipedia:Touch
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050976
name: detection of mechanical stimulus involved in sensory perception of touch
namespace: biological_process
def: "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "perception of touch, detection of mechanical stimulus" EXACT []
synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT []
synonym: "tactition, sensory detection of mechanical stimulus" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050975 ! sensory perception of touch

[Term]
id: GO:0050977
name: magnetoreception by sensory perception of chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception by chemical stimulus" EXACT []
synonym: "magnetoreception through chemical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of chemical stimulus" EXACT []
synonym: "magnetoreception, using chemical stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007606 ! sensory perception of chemical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050978
name: magnetoreception by sensory perception of electrical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception by electrical stimulus" EXACT []
synonym: "magnetoreception through electrical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of electrical stimulus" EXACT []
synonym: "magnetoreception, using electrical stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050952 ! sensory perception of electrical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050979
name: magnetoreception by sensory perception of mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception through mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of mechanical stimulus" EXACT []
synonym: "magnetoreception, using mechanical stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050954 ! sensory perception of mechanical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050980
name: detection of light stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception, detection of light stimulus" EXACT []
synonym: "magnetoreception, sensory detection of light stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of light stimulus during magnetoreception" EXACT []
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: part_of GO:0050958 ! magnetoreception

[Term]
id: GO:0050981
name: detection of electrical stimulus
namespace: biological_process
def: "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0051602 ! response to electrical stimulus

[Term]
id: GO:0050982
name: detection of mechanical stimulus
namespace: biological_process
def: "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0050983
name: obsolete deoxyhypusine biosynthetic process from spermidine
namespace: biological_process
def: "OBSOLETE. The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN]
comment: The reason for obsoletion is that although GO:0050983 is described as a multistep process, the entire reaction is carried out by a single enzyme, therefore was replacey by the molecular function GO:0034038 deoxyhypusine synthase activity.
synonym: "deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "deoxyhypusine formation from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT []
synonym: "spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase" EXACT []
synonym: "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT []
is_obsolete: true
consider: GO:0034038

[Term]
id: GO:0050984
name: obsolete peptidyl-serine sulfation
namespace: biological_process
def: "OBSOLETE. The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine." [RESID:AA0361]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050985
name: obsolete peptidyl-threonine sulfation
namespace: biological_process
def: "OBSOLETE. The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine." [RESID:AA0362]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050986
name: obsolete isopeptide cross-linking via N-(L-isoglutamyl)-glycine
namespace: biological_process
def: "OBSOLETE. The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050987
name: obsolete enzyme active site formation via O-sulfo-L-serine
namespace: biological_process
def: "OBSOLETE. The transient sulfation of peptidyl-serine to form O-sulfo-L-serine." [RESID:AA0361]
comment: This term was obsoleted because it was created by error: O-sulfo-L-serine is a post-translational modification, see PMID:14752058.
xref: RESID:AA0361
is_obsolete: true

[Term]
id: GO:0050988
name: obsolete N-terminal peptidyl-methionine carboxylation
namespace: biological_process
def: "OBSOLETE. The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0050989
name: N-terminal protein amino acid carboxylation
namespace: biological_process
def: "The carboxylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0050990
name: N-terminal protein amino acid carbamoylation
namespace: biological_process
def: "The carbamoylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "N-terminal protein amino acid carbamylation" EXACT []
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0050991
name: obsolete enzyme active site formation via O-sulfo-L-threonine
namespace: biological_process
def: "OBSOLETE. The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine." [RESID:AA0362]
comment: This term was obsoleted because it was created by error: O-sulfo-L-threonine is a post-translational modification, see PMID:14752058.
xref: RESID:AA0362
is_obsolete: true

[Term]
id: GO:0050992
name: dimethylallyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai]
synonym: "dimethylallyl diphosphate anabolism" EXACT []
synonym: "dimethylallyl diphosphate biosynthesis" EXACT []
synonym: "dimethylallyl diphosphate formation" EXACT []
synonym: "dimethylallyl diphosphate synthesis" EXACT []
synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT []
synonym: "dimethylallyl pyrophosphate biosynthetic process" EXACT []
synonym: "DPP biosynthesis" EXACT []
synonym: "DPP biosynthetic process" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0050993 ! dimethylallyl diphosphate metabolic process

[Term]
id: GO:0050993
name: dimethylallyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethylallyl diphosphate." [GOC:ai]
synonym: "dimethylallyl diphosphate metabolism" EXACT []
synonym: "dimethylallyl pyrophosphate metabolic process" EXACT []
synonym: "dimethylallyl pyrophosphate metabolism" EXACT []
synonym: "DPP metabolic process" EXACT []
synonym: "DPP metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:0050994
name: regulation of lipid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "regulation of lipid breakdown" EXACT []
synonym: "regulation of lipid catabolism" EXACT []
synonym: "regulation of lipid degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050995
name: negative regulation of lipid catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "down regulation of lipid catabolic process" EXACT []
synonym: "down-regulation of lipid catabolic process" EXACT []
synonym: "downregulation of lipid catabolic process" EXACT []
synonym: "inhibition of lipid catabolic process" NARROW []
synonym: "negative regulation of lipid breakdown" EXACT []
synonym: "negative regulation of lipid catabolism" EXACT []
synonym: "negative regulation of lipid degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: negatively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050996
name: positive regulation of lipid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "activation of lipid catabolic process" NARROW []
synonym: "positive regulation of lipid breakdown" EXACT []
synonym: "positive regulation of lipid catabolism" EXACT []
synonym: "positive regulation of lipid degradation" EXACT []
synonym: "stimulation of lipid catabolic process" NARROW []
synonym: "up regulation of lipid catabolic process" EXACT []
synonym: "up-regulation of lipid catabolic process" EXACT []
synonym: "upregulation of lipid catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: positively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050997
name: quaternary ammonium group binding
namespace: molecular_function
def: "Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]
synonym: "quaternary amine binding" EXACT []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0050998
name: nitric-oxide synthase binding
namespace: molecular_function
def: "Binding to nitric-oxide synthase." [GOC:ai]
synonym: "NOS binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0050999
name: regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "nitric-oxide synthase regulator" EXACT []
synonym: "NOS regulator" EXACT []
synonym: "regulation of NOS activity" EXACT []
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0051000
name: positive regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of nitric-oxide synthase activity" NARROW []
synonym: "nitric-oxide synthase activator" EXACT []
synonym: "NOS activator" EXACT []
synonym: "positive regulation of NOS activity" EXACT []
synonym: "stimulation of nitric-oxide synthase activity" NARROW []
synonym: "up regulation of nitric-oxide synthase activity" EXACT []
synonym: "up-regulation of nitric-oxide synthase activity" EXACT []
synonym: "upregulation of nitric-oxide synthase activity" EXACT []
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0050999 ! regulation of nitric-oxide synthase activity

[Term]
id: GO:0051001
name: negative regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of nitric-oxide synthase activity" EXACT []
synonym: "down-regulation of nitric-oxide synthase activity" EXACT []
synonym: "downregulation of nitric-oxide synthase activity" EXACT []
synonym: "inhibition of nitric-oxide synthase activity" NARROW []
synonym: "negative regulation of NOS activity" EXACT []
synonym: "nitric-oxide synthase inhibitor" NARROW []
synonym: "NOS inhibitor" NARROW []
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0050999 ! regulation of nitric-oxide synthase activity

[Term]
id: GO:0051002
name: ligase activity, forming nitrogen-metal bonds
namespace: molecular_function
def: "Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.6.-.-]
xref: EC:6.6.-.-
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0051003
name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-]
xref: EC:6.6.1.-
is_a: GO:0051002 ! ligase activity, forming nitrogen-metal bonds

[Term]
id: GO:0051004
name: regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0051005
name: negative regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of lipoprotein lipase activity" EXACT []
synonym: "down-regulation of lipoprotein lipase activity" EXACT []
synonym: "downregulation of lipoprotein lipase activity" EXACT []
synonym: "inhibition of lipoprotein lipase activity" NARROW []
is_a: GO:0051004 ! regulation of lipoprotein lipase activity
is_a: GO:0060192 ! negative regulation of lipase activity

[Term]
id: GO:0051006
name: positive regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of lipoprotein lipase activity" NARROW []
synonym: "stimulation of lipoprotein lipase activity" NARROW []
synonym: "up regulation of lipoprotein lipase activity" EXACT []
synonym: "up-regulation of lipoprotein lipase activity" EXACT []
synonym: "upregulation of lipoprotein lipase activity" EXACT []
is_a: GO:0051004 ! regulation of lipoprotein lipase activity
is_a: GO:0061365 ! positive regulation of triglyceride lipase activity

[Term]
id: GO:0051007
name: squalene-hopene cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17]
synonym: "squalene mutase (cyclizing)" RELATED [EC:5.4.99.17]
synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.17
xref: MetaCyc:5.4.99.17-RXN
xref: RHEA:17637
is_a: GO:0016866 ! intramolecular transferase activity
is_a: GO:0034072 ! squalene cyclase activity

[Term]
id: GO:0051008
name: Hsp27 protein binding
namespace: molecular_function
def: "Binding to Hsp27 proteins, a lightweight heat shock protein." [GOC:ai]
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0051009
name: O-acetylhomoserine sulfhydrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27822]
synonym: "homocysteine synthase" EXACT [PMID:36455053]
xref: MetaCyc:ACETYLHOMOSER-CYS-RXN
xref: RHEA:27822
is_a: GO:0003961 ! O-acetylhomoserine aminocarboxypropyltransferase activity
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0051010
name: microtubule plus-end binding
namespace: molecular_function
def: "Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0051011
name: microtubule minus-end binding
namespace: molecular_function
def: "Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0051012
name: microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule." [PMID:14557818, PMID:14614826]
synonym: "microtubule translocation" EXACT []
is_a: GO:0007018 ! microtubule-based movement

[Term]
id: GO:0051013
name: microtubule severing
namespace: biological_process
def: "The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends." [GOC:ai, PMID:27037673]
synonym: "microtubule severing activity" RELATED []
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0051014
name: actin filament severing
namespace: biological_process
def: "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]
synonym: "actin filament severing activity" RELATED []
synonym: "barbed-end actin capping/severing activity" RELATED []
synonym: "F-actin severing" EXACT []
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0051015
name: actin filament binding
namespace: molecular_function
def: "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]
synonym: "actin cross-linking activity" RELATED []
synonym: "F-actin binding" EXACT []
is_a: GO:0003779 ! actin binding
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0051016
name: barbed-end actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "barbed-end actin capping activity" EXACT []
synonym: "barbed-end F-actin capping activity" EXACT []
synonym: "plus-end actin filament capping activity" EXACT []
synonym: "plus-end F-actin capping activity" EXACT []
is_a: GO:0051693 ! actin filament capping

[Term]
id: GO:0051017
name: actin filament bundle assembly
namespace: biological_process
alt_id: GO:0045011
def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
synonym: "actin bundling activity" RELATED []
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0061572 ! actin filament bundle organization

[Term]
id: GO:0051018
name: protein kinase A binding
namespace: molecular_function
def: "Binding to a protein kinase A." [GOC:ai]
comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity.
synonym: "PKA binding" EXACT []
synonym: "protein kinase A anchoring activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051019
name: mitogen-activated protein kinase binding
namespace: molecular_function
def: "Binding to a mitogen-activated protein kinase." [GOC:ai]
synonym: "MAP kinase binding" EXACT []
synonym: "MAP-kinase anchoring activity" RELATED []
synonym: "MAPK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0051020
name: GTPase binding
namespace: molecular_function
def: "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0051021
name: GDP-dissociation inhibitor binding
namespace: molecular_function
def: "Binding to a GDP-dissociation inhibitor protein." [GOC:ai]
synonym: "GDI binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051022
name: Rho GDP-dissociation inhibitor binding
namespace: molecular_function
def: "Binding to a Rho GDP-dissociation inhibitor protein." [GOC:ai]
synonym: "Rho GDI binding" EXACT []
is_a: GO:0051021 ! GDP-dissociation inhibitor binding

[Term]
id: GO:0051026
name: chiasma assembly
namespace: biological_process
def: "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [PMID:23396135]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0051027
name: DNA transport
namespace: biological_process
def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport

[Term]
id: GO:0051028
name: mRNA transport
namespace: biological_process
def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051029
name: rRNA transport
namespace: biological_process
def: "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051030
name: snRNA transport
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051031
name: tRNA transport
namespace: biological_process
def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051032
name: nucleic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai]
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity

[Term]
id: GO:0051033
name: RNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol"
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity

[Term]
id: GO:0051034
name: tRNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051033 ! RNA transmembrane transporter activity

[Term]
id: GO:0051035
name: DNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity

[Term]
id: GO:0051036
name: regulation of endosome size
namespace: biological_process
def: "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai]
synonym: "endosome enlargement" RELATED []
is_a: GO:0097494 ! regulation of vesicle size

[Term]
id: GO:0051037
name: obsolete regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:go_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "meiotic regulation of transcription" EXACT []
synonym: "regulation of transcription, meiotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006357
consider: GO:0051321

[Term]
id: GO:0051038
name: obsolete negative regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle." [GOC:ai]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "downregulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "inhibition of transcription during meiosis" NARROW [GOC:mah]
synonym: "meiotic repression of transcription" EXACT []
synonym: "negative regulation of meiotic transcription" EXACT []
synonym: "negative regulation of transcription, meiotic" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0000122
consider: GO:0051321

[Term]
id: GO:0051039
name: obsolete positive regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:ai]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription during meiosis" NARROW [GOC:mah]
synonym: "positive regulation of meiotic transcription" EXACT []
synonym: "positive regulation of transcription, meiotic" EXACT [GOC:mah]
synonym: "stimulation of transcription during meiosis" NARROW [GOC:mah]
synonym: "up regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "upregulation of transcription during meiosis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0045944
consider: GO:0051321

[Term]
id: GO:0051040
name: regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

[Term]
id: GO:0051041
name: positive regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]
synonym: "activation of calcium-independent cell-cell adhesion" NARROW []
synonym: "stimulation of calcium-independent cell-cell adhesion" NARROW []
synonym: "up regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "up-regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "upregulation of calcium-independent cell-cell adhesion" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion
relationship: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

[Term]
id: GO:0051042
name: negative regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]
synonym: "down regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "down-regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "downregulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "inhibition of calcium-independent cell-cell adhesion" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion
relationship: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

[Term]
id: GO:0051043
name: regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai]
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051044
name: positive regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai]
synonym: "activation of membrane protein ectodomain proteolysis" NARROW []
synonym: "stimulation of membrane protein ectodomain proteolysis" NARROW []
synonym: "up regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "up-regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "upregulation of membrane protein ectodomain proteolysis" EXACT []
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis
relationship: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051045
name: negative regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai]
synonym: "down regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "down-regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "downregulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "inhibition of membrane protein ectodomain proteolysis" NARROW []
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis
relationship: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051046
name: regulation of secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0046903 ! secretion

[Term]
id: GO:0051047
name: positive regulation of secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "activation of secretion" NARROW []
synonym: "stimulation of secretion" NARROW []
synonym: "up regulation of secretion" EXACT []
synonym: "up-regulation of secretion" EXACT []
synonym: "upregulation of secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051048
name: negative regulation of secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "down regulation of secretion" EXACT []
synonym: "down-regulation of secretion" EXACT []
synonym: "downregulation of secretion" EXACT []
synonym: "inhibition of secretion" NARROW []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051049
name: regulation of transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_yeast
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0006810 ! transport

[Term]
id: GO:0051050
name: positive regulation of transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of transport" NARROW []
synonym: "stimulation of transport" NARROW []
synonym: "up regulation of transport" EXACT []
synonym: "up-regulation of transport" EXACT []
synonym: "upregulation of transport" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051049 ! regulation of transport
relationship: positively_regulates GO:0006810 ! transport

[Term]
id: GO:0051051
name: negative regulation of transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of transport" EXACT []
synonym: "down-regulation of transport" EXACT []
synonym: "downregulation of transport" EXACT []
synonym: "inhibition of transport" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051049 ! regulation of transport
relationship: negatively_regulates GO:0006810 ! transport

[Term]
id: GO:0051052
name: regulation of DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: goslim_yeast
synonym: "regulation of DNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051053
name: negative regulation of DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
synonym: "down regulation of DNA metabolic process" EXACT []
synonym: "down-regulation of DNA metabolic process" EXACT []
synonym: "downregulation of DNA metabolic process" EXACT []
synonym: "inhibition of DNA metabolic process" NARROW []
synonym: "negative regulation of DNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: negatively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051054
name: positive regulation of DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
synonym: "activation of DNA metabolic process" NARROW []
synonym: "positive regulation of DNA metabolism" EXACT []
synonym: "stimulation of DNA metabolic process" NARROW []
synonym: "up regulation of DNA metabolic process" EXACT []
synonym: "up-regulation of DNA metabolic process" EXACT []
synonym: "upregulation of DNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: positively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051055
name: negative regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "down regulation of lipid biosynthetic process" EXACT []
synonym: "down-regulation of lipid biosynthetic process" EXACT []
synonym: "downregulation of lipid biosynthetic process" EXACT []
synonym: "inhibition of lipid biosynthetic process" NARROW []
synonym: "negative regulation of lipid anabolism" EXACT []
synonym: "negative regulation of lipid biosynthesis" EXACT []
synonym: "negative regulation of lipid formation" EXACT []
synonym: "negative regulation of lipid synthesis" EXACT []
synonym: "negative regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0051056
name: regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
synonym: "regulation of small GTPase-mediated signal transduction" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0051057
name: positive regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]
synonym: "activation of small GTPase mediated signal transduction" NARROW []
synonym: "positive regulation of small GTPase-mediated signal transduction" EXACT []
synonym: "stimulation of small GTPase mediated signal transduction" NARROW []
synonym: "up regulation of small GTPase mediated signal transduction" EXACT []
synonym: "up-regulation of small GTPase mediated signal transduction" EXACT []
synonym: "upregulation of small GTPase mediated signal transduction" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0051058
name: negative regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]
synonym: "down regulation of small GTPase mediated signal transduction" EXACT []
synonym: "down-regulation of small GTPase mediated signal transduction" EXACT []
synonym: "downregulation of small GTPase mediated signal transduction" EXACT []
synonym: "inhibition of small GTPase mediated signal transduction" NARROW []
synonym: "negative regulation of small GTPase-mediated signal transduction" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0007264 ! small GTPase-mediated signal transduction

[Term]
id: GO:0051059
name: NF-kappaB binding
namespace: molecular_function
def: "Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]
is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding

[Term]
id: GO:0051060
name: pullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41]
synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT []
synonym: "amylopectin 6-glucanohydrolase activity" EXACT []
synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41]
synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41]
synonym: "limit dextrinase" RELATED []
synonym: "pullulan 6-glucanohydrolase activity" EXACT []
synonym: "pullulan alpha-1,6-glucanohydrolase activity" RELATED [EC:3.2.1.41]
synonym: "R-enzyme" RELATED [EC:3.2.1.41]
xref: EC:3.2.1.41
xref: MetaCyc:RXN-1824
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051061
name: ADP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN]
synonym: "ADP reduction" RELATED []
xref: MetaCyc:ADPREDUCT-RXN
xref: RHEA:28034
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

[Term]
id: GO:0051062
name: UDP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN]
synonym: "UDP reduction" RELATED []
xref: MetaCyc:UDPREDUCT-RXN
xref: RHEA:28026
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

[Term]
id: GO:0051063
name: CDP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN]
synonym: "CDP reduction" RELATED []
xref: MetaCyc:CDPREDUCT-RXN
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

[Term]
id: GO:0051064
name: obsolete TTP reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]
comment: The reason for obsoletion is that this term is more specific than the specificity of any known gene product.
synonym: "TTP reduction" RELATED []
is_obsolete: true
replaced_by: GO:0008998

[Term]
id: GO:0051065
name: obsolete CTP reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]
comment: The reason for obsoletion is that this term is more specific than the specificity of any known gene product.
synonym: "CTP reduction" RELATED []
is_obsolete: true
replaced_by: GO:0008998

[Term]
id: GO:0051066
name: dihydrobiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [PMID:2557335]
synonym: "6,7-dihydrobiopterin metabolic process" NARROW [CHEBI:20680]
synonym: "7,8-dihydrobiopterin metabolic process" NARROW [CHEBI:15375]
synonym: "dihydrobiopterin reduction" NARROW []
synonym: "dihydropterin metabolic process" EXACT [CHEBI:38797]
synonym: "dihydropterin metabolism" EXACT []
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0051067
name: dihydropteridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4." [PMID:2557335]
synonym: "6,7-dihydropteridine metabolic process" EXACT [PMID:19567870]
synonym: "dihydropteridine metabolism" EXACT []
synonym: "dihydropteridine reduction" NARROW []
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0051068
name: dihydrolipoamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464]
synonym: "dihydrolipoamide metabolism" EXACT []
synonym: "dihydrolipoamide reduction" NARROW []
synonym: "dihydrothioctamide metabolic process" EXACT []
synonym: "dihydrothioctamide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0051069
name: galactomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [PMID:30701316, PMID:33012173]
synonym: "galactomannan metabolism" EXACT []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0051070
name: galactomannan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai]
synonym: "galactomannan anabolism" EXACT []
synonym: "galactomannan biosynthesis" EXACT []
synonym: "galactomannan formation" EXACT []
synonym: "galactomannan synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0051069 ! galactomannan metabolic process

[Term]
id: GO:0051071
name: 4,6-pyruvylated galactose residue metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]
synonym: "4,6-pyruvylated galactose residue metabolism" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism" EXACT []
synonym: "PvGal metabolic process" EXACT []
synonym: "PvGal metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0051072
name: 4,6-pyruvylated galactose residue biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]
synonym: "4,6-pyruvylated galactose residue anabolism" EXACT []
synonym: "4,6-pyruvylated galactose residue biosynthesis" EXACT []
synonym: "4,6-pyruvylated galactose residue formation" EXACT []
synonym: "4,6-pyruvylated galactose residue synthesis" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process" EXACT []
synonym: "PvGal biosynthesis" EXACT []
synonym: "PvGal biosynthetic process" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process

[Term]
id: GO:0051073
name: adenosylcobinamide-GDP ribazoletransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN]
synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" RELATED [EC:2.7.8.26]
synonym: "cobalamin (5'-phosphate) synthase activity" RELATED [EC:2.7.8.26]
synonym: "cobalamin synthase activity" EXACT []
synonym: "cobalamin-5'-phosphate synthase activity" RELATED [EC:2.7.8.26]
synonym: "CobS" RELATED [EC:2.7.8.26]
xref: EC:2.7.8.26
xref: MetaCyc:COBALAMINSYN-RXN
xref: RHEA:16049
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0051074
name: obsolete protein tetramerization activity
namespace: molecular_function
def: "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]
comment: This term was made obsolete because it represents a process.
synonym: "protein tetramerization activity" EXACT []
is_obsolete: true
replaced_by: GO:0051262

[Term]
id: GO:0051075
name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA." [PMID:12731872]
synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT []
xref: EC:2.4.99.17
xref: RHEA:32155
is_a: GO:0016757 ! glycosyltransferase activity
is_a: GO:0016853 ! isomerase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0051077
name: secondary cell septum
namespace: cellular_component
def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814]
synonym: "secondary septum" BROAD []
is_a: GO:0000935 ! division septum

[Term]
id: GO:0051078
name: meiotic nuclear membrane disassembly
namespace: biological_process
def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf]
synonym: "meiotic nuclear envelope breakdown" RELATED []
synonym: "meiotic nuclear envelope catabolism" RELATED []
synonym: "meiotic nuclear envelope degradation" RELATED []
synonym: "meiotic nuclear envelope disassembly" RELATED []
is_a: GO:0051081 ! nuclear membrane disassembly
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0051079
name: meiosis I nuclear membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear membranes during the first division of meiosis." [GOC:bf]
synonym: "meiosis I nuclear envelope breakdown" RELATED []
synonym: "meiosis I nuclear envelope catabolism" RELATED []
synonym: "meiosis I nuclear envelope degradation" RELATED []
synonym: "meiosis I nuclear envelope disassembly" RELATED []
is_a: GO:0051078 ! meiotic nuclear membrane disassembly
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0051080
name: meiosis II nuclear membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear membranes during the second division of meiosis." [GOC:bf]
synonym: "meiosis II nuclear envelope breakdown" RELATED []
synonym: "meiosis II nuclear envelope catabolism" RELATED []
synonym: "meiosis II nuclear envelope degradation" RELATED []
synonym: "meiosis II nuclear envelope disassembly" RELATED []
is_a: GO:0051078 ! meiotic nuclear membrane disassembly
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0051081
name: nuclear membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai]
synonym: "nuclear envelope breakdown" RELATED []
synonym: "nuclear envelope catabolism" RELATED []
synonym: "nuclear envelope degradation" RELATED []
synonym: "nuclear envelope disassembly" RELATED []
is_a: GO:0030397 ! membrane disassembly
is_a: GO:0071763 ! nuclear membrane organization

[Term]
id: GO:0051082
name: unfolded protein binding
namespace: molecular_function
def: "Binding to an unfolded protein." [GOC:ai]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "chaperone activity" BROAD []
xref: Reactome:R-HSA-9683772 "Trimmed spike protein binds to calnexin"
xref: Reactome:R-HSA-9694337 "Trimmed spike protein binds to calnexin"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051083
name: 'de novo' cotranslational protein folding
namespace: biological_process
alt_id: GO:0006444
def: "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb]
synonym: "'de novo' co-translational protein folding" EXACT []
synonym: "multidomain protein assembly" EXACT []
synonym: "nascent polypeptide association" EXACT []
is_a: GO:0006458 ! 'de novo' protein folding

[Term]
id: GO:0051084
name: 'de novo' post-translational protein folding
namespace: biological_process
def: "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb]
synonym: "'de novo' posttranslational protein folding" EXACT []
is_a: GO:0006458 ! 'de novo' protein folding

[Term]
id: GO:0051085
name: chaperone cofactor-dependent protein refolding
namespace: biological_process
alt_id: GO:0070389
def: "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]
synonym: "chaperone co-factor-dependent protein folding" RELATED []
synonym: "chaperone co-factor-dependent protein refolding" EXACT []
synonym: "chaperone cofactor-dependent 'de novo' protein folding" EXACT [GOC:mah]
synonym: "chaperone cofactor-dependent protein folding" EXACT [GOC:rb]
synonym: "chaperone mediated protein folding requiring cofactor" RELATED []
is_a: GO:0051084 ! 'de novo' post-translational protein folding
is_a: GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:0051086
name: chaperone mediated protein folding independent of cofactor
namespace: biological_process
def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb]
synonym: "chaperone cofactor-independent protein folding" EXACT [GOC:rb]
is_a: GO:0051084 ! 'de novo' post-translational protein folding
is_a: GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:0051087
name: protein-folding chaperone binding
namespace: molecular_function
def: "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]
synonym: "chaperone binding" BROAD []
synonym: "chaperone protein binding" EXACT []
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051088
name: obsolete PMA-inducible membrane protein ectodomain proteolysis
namespace: biological_process
def: "OBSOLETE. The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508]
comment: This term was obsoleted because it represents an assay to induce PKC.
is_obsolete: true

[Term]
id: GO:0051089
name: constitutive protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508]
is_a: GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051090
name: regulation of DNA-binding transcription factor activity
namespace: biological_process
alt_id: GO:1904167
alt_id: GO:2000823
def: "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "regulation of androgen receptor activity" NARROW []
synonym: "regulation of DNA binding transcription factor activity" EXACT []
synonym: "regulation of sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "regulation of thyroid hormone receptor activity" NARROW []
synonym: "regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb]
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0051091
name: positive regulation of DNA-binding transcription factor activity
namespace: biological_process
alt_id: GO:1904169
def: "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of transcription factor activity" NARROW []
synonym: "positive regulation of DNA binding transcription factor activity" EXACT []
synonym: "positive regulation of sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "positive regulation of thyroid hormone receptor activity" NARROW []
synonym: "positive regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb]
synonym: "stimulation of transcription factor activity" NARROW []
synonym: "up regulation of transcription factor activity" EXACT []
synonym: "up-regulation of transcription factor activity" EXACT []
synonym: "upregulation of transcription factor activity" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity

[Term]
id: GO:0051092
name: positive regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
subset: gocheck_obsoletion_candidate
synonym: "activation of NF-kappaB" EXACT []
synonym: "activation of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "NF-kappaB activation" EXACT []
is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity

[Term]
id: GO:0051093
name: negative regulation of developmental process
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
synonym: "down regulation of developmental process" EXACT []
synonym: "down-regulation of developmental process" EXACT []
synonym: "downregulation of developmental process" EXACT []
synonym: "inhibition of developmental process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
relationship: negatively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051094
name: positive regulation of developmental process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
synonym: "activation of developmental process" NARROW []
synonym: "stimulation of developmental process" NARROW []
synonym: "up regulation of developmental process" EXACT []
synonym: "up-regulation of developmental process" EXACT []
synonym: "upregulation of developmental process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
relationship: positively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051095
name: regulation of helicase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of helicase activity." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0043462 ! regulation of ATP-dependent activity
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051096
name: positive regulation of helicase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a helicase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of helicase activity" NARROW []
synonym: "stimulation of helicase activity" NARROW []
synonym: "up regulation of helicase activity" EXACT []
synonym: "up-regulation of helicase activity" EXACT []
synonym: "upregulation of helicase activity" EXACT []
is_a: GO:0032781 ! positive regulation of ATP-dependent activity
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051095 ! regulation of helicase activity

[Term]
id: GO:0051097
name: negative regulation of helicase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a helicase." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of helicase activity" EXACT []
synonym: "down-regulation of helicase activity" EXACT []
synonym: "downregulation of helicase activity" EXACT []
synonym: "inhibition of helicase activity" NARROW []
is_a: GO:0032780 ! negative regulation of ATP-dependent activity
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051095 ! regulation of helicase activity

[Term]
id: GO:0051098
name: regulation of binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0051099
name: positive regulation of binding
namespace: biological_process
def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "activation of binding" NARROW []
synonym: "stimulation of binding" NARROW []
synonym: "up regulation of binding" EXACT []
synonym: "up-regulation of binding" EXACT []
synonym: "upregulation of binding" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051100
name: negative regulation of binding
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "down regulation of binding" EXACT []
synonym: "down-regulation of binding" EXACT []
synonym: "downregulation of binding" EXACT []
synonym: "inhibition of binding" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051101
name: regulation of DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051102
name: DNA ligation involved in DNA recombination
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination." [GOC:ai]
synonym: "DNA ligation during DNA recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006266 ! DNA ligation
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0051103
name: DNA ligation involved in DNA repair
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]
synonym: "DNA ligation during DNA repair" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006266 ! DNA ligation
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0051104
name: DNA-dependent DNA replication DNA ligation
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication." [GOC:ai, GOC:dph, GOC:tb]
synonym: "DNA ligation during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb]
synonym: "DNA ligation involved in DNA-dependent DNA replication" EXACT []
is_a: GO:0006266 ! DNA ligation
relationship: part_of GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0051105
name: regulation of DNA ligation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051106
name: positive regulation of DNA ligation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
synonym: "activation of DNA ligation" NARROW []
synonym: "stimulation of DNA ligation" NARROW []
synonym: "up regulation of DNA ligation" EXACT []
synonym: "up-regulation of DNA ligation" EXACT []
synonym: "upregulation of DNA ligation" EXACT []
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0051105 ! regulation of DNA ligation
relationship: positively_regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051107
name: negative regulation of DNA ligation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
synonym: "down regulation of DNA ligation" EXACT []
synonym: "down-regulation of DNA ligation" EXACT []
synonym: "downregulation of DNA ligation" EXACT []
synonym: "inhibition of DNA ligation" NARROW []
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0051105 ! regulation of DNA ligation
relationship: negatively_regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051108
name: carnitine-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN]
synonym: "carnitine synthetase activity" EXACT []
synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD []
xref: MetaCyc:DCARNCOALIG-RXN
xref: RHEA:30543
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0051109
name: crotonobetaine-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN]
synonym: "crotonobetaine-CoA synthase activity" EXACT []
synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD []
xref: MetaCyc:CROTCOALIG-RXN
xref: RHEA:30079
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0051110
name: obsolete peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def: "OBSOLETE. The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051111
name: peptidyl-histidine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0371
is_a: GO:0018117 ! protein adenylylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0051112
name: obsolete peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def: "OBSOLETE. The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051113
name: obsolete enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def: "OBSOLETE. The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:15182206.
xref: RESID:AA0371
is_obsolete: true

[Term]
id: GO:0051114
name: peptidyl-histidine uridylylation
namespace: biological_process
def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0372
is_a: GO:0018177 ! protein uridylylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0051115
name: obsolete enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def: "OBSOLETE. The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]
comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:8794735.
xref: RESID:AA0372
is_obsolete: true
consider: GO:0017103

[Term]
id: GO:0051116
name: cobaltochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H+ + phosphate." [EC:6.6.1.2, RHEA:15341]
synonym: "CobN-CobST" RELATED [EC:6.6.1.2]
synonym: "CobNST" NARROW []
synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT []
synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" RELATED [EC:6.6.1.2]
xref: EC:6.6.1.2
xref: KEGG_REACTION:R05227
xref: MetaCyc:R342-RXN
xref: RHEA:15341
is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes

[Term]
id: GO:0051117
name: ATPase binding
namespace: molecular_function
def: "Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0051118
name: glucan endo-1,3-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59]
synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" RELATED [EC:3.2.1.59]
synonym: "cariogenanase activity" RELATED [EC:3.2.1.59]
synonym: "cariogenase activity" RELATED [EC:3.2.1.59]
synonym: "endo-(1->3)-alpha-glucanase activity" RELATED [EC:3.2.1.59]
synonym: "endo-1,3-alpha-D-glucanase activity" RELATED [EC:3.2.1.59]
synonym: "endo-1,3-alpha-glucanase activity" RELATED [EC:3.2.1.59]
synonym: "mutanase activity" RELATED [EC:3.2.1.59]
xref: EC:3.2.1.59
xref: MetaCyc:3.2.1.59-RXN
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0051119
name: sugar transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "sugar/polyol channel activity" NARROW []
xref: Reactome:R-HSA-428779 "GLUT7 and GLUT11 transport glucose and fructose"
xref: Reactome:R-HSA-8875902 "SLC45A3 transports Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-8876319 "SLC50A1 transports Glc from cytosol to extracellular region"
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0051120
name: hepoxilin A3 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3." [PMID:15123652]
xref: Reactome:R-HSA-2161794 "Arachidonate is converted to HXA3/B3 by ALOX12"
xref: Reactome:R-HSA-8942208 "ALOXE3 isomerises 12R-HpETE to HXA3"
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0051121
name: hepoxilin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652]
synonym: "hepoxilin metabolism" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process

[Term]
id: GO:0051122
name: hepoxilin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai]
synonym: "hepoxilin anabolism" EXACT []
synonym: "hepoxilin biosynthesis" EXACT []
synonym: "hepoxilin formation" EXACT []
synonym: "hepoxilin synthesis" EXACT []
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:0051121 ! hepoxilin metabolic process

[Term]
id: GO:0051123
name: RNA polymerase II preinitiation complex assembly
namespace: biological_process
def: "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]
synonym: "RNA polymerase II transcription PIC biosynthesis" EXACT []
synonym: "RNA polymerase II transcription PIC formation" EXACT []
synonym: "RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "RNA polymerase II transcriptional preinitiation complex formation" EXACT []
is_a: GO:0070897 ! transcription preinitiation complex assembly
relationship: part_of GO:0006367 ! transcription initiation at RNA polymerase II promoter

[Term]
id: GO:0051124
name: synaptic assembly at neuromuscular junction
namespace: biological_process
def: "The assembly of a synapse at a neuromuscular junction." [PMID:20215342]
synonym: "cholinergic synaptogenesis" RELATED []
synonym: "synaptic growth at neuromuscular junction" RELATED []
is_a: GO:0007416 ! synapse assembly
is_a: GO:0007528 ! neuromuscular junction development
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0051125
name: regulation of actin nucleation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
is_a: GO:0110053 ! regulation of actin filament organization
relationship: regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051126
name: negative regulation of actin nucleation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
synonym: "down regulation of actin nucleation" EXACT []
synonym: "down-regulation of actin nucleation" EXACT []
synonym: "downregulation of actin nucleation" EXACT []
synonym: "inhibition of actin nucleation" NARROW []
is_a: GO:0051125 ! regulation of actin nucleation
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051127
name: positive regulation of actin nucleation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
synonym: "activation of actin nucleation" NARROW []
synonym: "stimulation of actin nucleation" NARROW []
synonym: "up regulation of actin nucleation" EXACT []
synonym: "up-regulation of actin nucleation" EXACT []
synonym: "upregulation of actin nucleation" EXACT []
is_a: GO:0051125 ! regulation of actin nucleation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051128
name: regulation of cellular component organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "regulation of cell organisation" RELATED [GOC:mah]
synonym: "regulation of cell organization" RELATED [GOC:mah]
synonym: "regulation of cellular component organisation" EXACT []
synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051129
name: negative regulation of cellular component organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "down regulation of cell organization" EXACT []
synonym: "down-regulation of cell organization" EXACT []
synonym: "downregulation of cell organization" EXACT []
synonym: "inhibition of cell organization" NARROW []
synonym: "negative regulation of cell organisation" RELATED [GOC:mah]
synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: negatively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051130
name: positive regulation of cellular component organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "activation of cell organization" NARROW []
synonym: "positive regulation of cell organisation" EXACT []
synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell organization" NARROW []
synonym: "up regulation of cell organization" EXACT []
synonym: "up-regulation of cell organization" EXACT []
synonym: "upregulation of cell organization" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: positively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051131
name: chaperone-mediated protein complex assembly
namespace: biological_process
alt_id: GO:0034619
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]
synonym: "cellular chaperone-mediated protein complex assembly" EXACT []
synonym: "chaperone activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0051132
name: NK T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
synonym: "natural killer T cell activation" EXACT []
synonym: "natural T cell activation" EXACT []
synonym: "NK T lymphocyte activation" EXACT []
synonym: "NK T-cell activation" EXACT []
synonym: "NK T-lymphocyte activation" EXACT []
synonym: "NKT cell activation" EXACT []
synonym: "NT cell activation" EXACT []
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0051133
name: regulation of NK T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "regulation of natural killer T cell activation" EXACT []
synonym: "regulation of natural T cell activation" EXACT []
synonym: "regulation of NK T lymphocyte activation" EXACT []
synonym: "regulation of NK T-cell activation" EXACT []
synonym: "regulation of NK T-lymphocyte activation" EXACT []
synonym: "regulation of NKT cell activation" EXACT []
synonym: "regulation of NT cell activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051134
name: negative regulation of NK T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "down regulation of NK T cell activation" EXACT []
synonym: "down-regulation of NK T cell activation" EXACT []
synonym: "downregulation of NK T cell activation" EXACT []
synonym: "inhibition of NK T cell activation" NARROW []
synonym: "negative regulation of natural killer T cell activation" EXACT []
synonym: "negative regulation of natural T cell activation" EXACT []
synonym: "negative regulation of NK T lymphocyte activation" EXACT []
synonym: "negative regulation of NK T-cell activation" EXACT []
synonym: "negative regulation of NK T-lymphocyte activation" EXACT []
synonym: "negative regulation of NKT cell activation" EXACT []
synonym: "negative regulation of NT cell activation" EXACT []
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0051133 ! regulation of NK T cell activation
relationship: negatively_regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051135
name: positive regulation of NK T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "activation of NK T cell activation" NARROW []
synonym: "positive regulation of natural killer T cell activation" EXACT []
synonym: "positive regulation of natural T cell activation" EXACT []
synonym: "positive regulation of NK T lymphocyte activation" EXACT []
synonym: "positive regulation of NK T-cell activation" EXACT []
synonym: "positive regulation of NK T-lymphocyte activation" EXACT []
synonym: "positive regulation of NKT cell activation" EXACT []
synonym: "positive regulation of NT cell activation" EXACT []
synonym: "stimulation of NK T cell activation" NARROW []
synonym: "up regulation of NK T cell activation" EXACT []
synonym: "up-regulation of NK T cell activation" EXACT []
synonym: "upregulation of NK T cell activation" EXACT []
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0051133 ! regulation of NK T cell activation
relationship: positively_regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051136
name: regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of natural killer T cell differentiation" EXACT []
synonym: "regulation of natural T cell differentiation" EXACT []
synonym: "regulation of NK T cell development" RELATED [GOC:add]
synonym: "regulation of NK T lymphocyte differentiation" EXACT []
synonym: "regulation of NK T-cell differentiation" EXACT []
synonym: "regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "regulation of NKT cell differentiation" EXACT []
synonym: "regulation of NT cell differentiation" EXACT []
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051137
name: negative regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of NK T cell differentiation" EXACT []
synonym: "down-regulation of NK T cell differentiation" EXACT []
synonym: "downregulation of NK T cell differentiation" EXACT []
synonym: "inhibition of NK T cell differentiation" NARROW []
synonym: "negative regulation of natural killer T cell differentiation" EXACT []
synonym: "negative regulation of natural T cell differentiation" EXACT []
synonym: "negative regulation of NK T cell development" RELATED [GOC:add]
synonym: "negative regulation of NK T lymphocyte differentiation" EXACT []
synonym: "negative regulation of NK T-cell differentiation" EXACT []
synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of NKT cell differentiation" EXACT []
synonym: "negative regulation of NT cell differentiation" EXACT []
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
is_a: GO:0051136 ! regulation of NK T cell differentiation
relationship: negatively_regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051138
name: positive regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of NK T cell differentiation" NARROW []
synonym: "positive regulation of natural killer T cell differentiation" EXACT []
synonym: "positive regulation of natural T cell differentiation" EXACT []
synonym: "positive regulation of NK T cell development" RELATED [GOC:add]
synonym: "positive regulation of NK T lymphocyte differentiation" EXACT []
synonym: "positive regulation of NK T-cell differentiation" EXACT []
synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of NKT cell differentiation" EXACT []
synonym: "positive regulation of NT cell differentiation" EXACT []
synonym: "stimulation of NK T cell differentiation" NARROW []
synonym: "up regulation of NK T cell differentiation" EXACT []
synonym: "up-regulation of NK T cell differentiation" EXACT []
synonym: "upregulation of NK T cell differentiation" EXACT []
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:0051136 ! regulation of NK T cell differentiation
relationship: positively_regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051139
name: metal cation:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg]
synonym: "metal ion:hydrogen antiporter activity" EXACT []
synonym: "metal ion:proton antiporter activity" EXACT []
xref: Reactome:R-HSA-435171 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages"
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0140828 ! metal cation:monoatomic cation antiporter activity

[Term]
id: GO:0051140
name: regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "regulation of natural killer T cell proliferation" EXACT []
synonym: "regulation of natural T cell proliferation" EXACT []
synonym: "regulation of NK T lymphocyte proliferation" EXACT []
synonym: "regulation of NK T-cell proliferation" EXACT []
synonym: "regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "regulation of NKT cell proliferation" EXACT []
synonym: "regulation of NT cell proliferation" EXACT []
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
is_a: GO:0051133 ! regulation of NK T cell activation
relationship: regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051141
name: negative regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "down regulation of NK T cell proliferation" EXACT []
synonym: "down-regulation of NK T cell proliferation" EXACT []
synonym: "downregulation of NK T cell proliferation" EXACT []
synonym: "inhibition of NK T cell proliferation" NARROW []
synonym: "negative regulation of natural killer T cell proliferation" EXACT []
synonym: "negative regulation of natural T cell proliferation" EXACT []
synonym: "negative regulation of NK T lymphocyte proliferation" EXACT []
synonym: "negative regulation of NK T-cell proliferation" EXACT []
synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "negative regulation of NKT cell proliferation" EXACT []
synonym: "negative regulation of NT cell proliferation" EXACT []
is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation
is_a: GO:0051134 ! negative regulation of NK T cell activation
is_a: GO:0051140 ! regulation of NK T cell proliferation
relationship: negatively_regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051142
name: positive regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "activation of NK T cell proliferation" NARROW []
synonym: "positive regulation of natural killer T cell proliferation" EXACT []
synonym: "positive regulation of natural T cell proliferation" EXACT []
synonym: "positive regulation of NK T lymphocyte proliferation" EXACT []
synonym: "positive regulation of NK T-cell proliferation" EXACT []
synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "positive regulation of NKT cell proliferation" EXACT []
synonym: "positive regulation of NT cell proliferation" EXACT []
synonym: "stimulation of NK T cell proliferation" NARROW []
synonym: "up regulation of NK T cell proliferation" EXACT []
synonym: "up-regulation of NK T cell proliferation" EXACT []
synonym: "upregulation of NK T cell proliferation" EXACT []
is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation
is_a: GO:0051135 ! positive regulation of NK T cell activation
is_a: GO:0051140 ! regulation of NK T cell proliferation
relationship: positively_regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051143
name: propanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [PMID:15995211]
synonym: "1,2-dihydroxypropane metabolic process" EXACT []
synonym: "1,2-dihydroxypropane metabolism" EXACT []
synonym: "propanediol metabolism" EXACT []
synonym: "propylene glycol metabolic process" EXACT []
synonym: "propylene glycol metabolism" EXACT []
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0051144
name: propanediol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai]
synonym: "1,2-dihydroxypropane catabolic process" EXACT []
synonym: "1,2-dihydroxypropane catabolism" EXACT []
synonym: "propanediol breakdown" EXACT []
synonym: "propanediol catabolism" EXACT []
synonym: "propanediol degradation" EXACT []
synonym: "propylene glycol catabolic process" EXACT []
synonym: "propylene glycol catabolism" EXACT []
is_a: GO:0042846 ! glycol catabolic process
is_a: GO:0051143 ! propanediol metabolic process

[Term]
id: GO:0051145
name: smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]
synonym: "nonstriated muscle cell differentiation" EXACT []
is_a: GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051146
name: striated muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai]
synonym: "voluntary muscle cell differentiation" NARROW []
is_a: GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051147
name: regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051148
name: negative regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "down regulation of muscle cell differentiation" EXACT []
synonym: "down-regulation of muscle cell differentiation" EXACT []
synonym: "downregulation of muscle cell differentiation" EXACT []
synonym: "inhibition of muscle cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: negatively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051149
name: positive regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "activation of muscle cell differentiation" NARROW []
synonym: "stimulation of muscle cell differentiation" NARROW []
synonym: "up regulation of muscle cell differentiation" EXACT []
synonym: "up-regulation of muscle cell differentiation" EXACT []
synonym: "upregulation of muscle cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: positively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051150
name: regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051151
name: negative regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "down regulation of smooth muscle cell differentiation" EXACT []
synonym: "down-regulation of smooth muscle cell differentiation" EXACT []
synonym: "downregulation of smooth muscle cell differentiation" EXACT []
synonym: "inhibition of smooth muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051152
name: positive regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "activation of smooth muscle cell differentiation" NARROW []
synonym: "stimulation of smooth muscle cell differentiation" NARROW []
synonym: "up regulation of smooth muscle cell differentiation" EXACT []
synonym: "up-regulation of smooth muscle cell differentiation" EXACT []
synonym: "upregulation of smooth muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051153
name: regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051154
name: negative regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "down regulation of striated muscle cell differentiation" EXACT []
synonym: "down-regulation of striated muscle cell differentiation" EXACT []
synonym: "downregulation of striated muscle cell differentiation" EXACT []
synonym: "inhibition of striated muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051155
name: positive regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "activation of striated muscle cell differentiation" NARROW []
synonym: "stimulation of striated muscle cell differentiation" NARROW []
synonym: "up regulation of striated muscle cell differentiation" EXACT []
synonym: "up-regulation of striated muscle cell differentiation" EXACT []
synonym: "upregulation of striated muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051156
name: glucose 6-phosphate metabolic process
namespace: biological_process
alt_id: GO:0006010
def: "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
synonym: "glucose 6-phosphate metabolism" EXACT []
synonym: "glucose 6-phosphate utilization" RELATED [GOC:mah]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0051157
name: arabitol catabolic process
namespace: biological_process
alt_id: GO:0019591
def: "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "arabitol breakdown" EXACT []
synonym: "arabitol catabolism" EXACT []
synonym: "arabitol degradation" EXACT []
synonym: "arabitol utilization" RELATED [GOC:mah]
is_a: GO:0019527 ! pentitol catabolic process
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051158
name: L-arabitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "L-arabitol breakdown" EXACT []
synonym: "L-arabitol catabolism" EXACT []
synonym: "L-arabitol degradation" EXACT []
is_a: GO:0051157 ! arabitol catabolic process
is_a: GO:0051162 ! L-arabitol metabolic process

[Term]
id: GO:0051159
name: D-arabitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
synonym: "D-arabitol breakdown" EXACT []
synonym: "D-arabitol catabolism" EXACT []
synonym: "D-arabitol degradation" EXACT []
is_a: GO:0051157 ! arabitol catabolic process
is_a: GO:0051163 ! D-arabitol metabolic process

[Term]
id: GO:0051160
name: xylitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai]
comment: Note that xylitol is a meso compound, thus there are no L or D-versions.
synonym: "L-xylitol breakdown" EXACT []
synonym: "L-xylitol catabolism" EXACT []
synonym: "L-xylitol degradation" EXACT []
is_a: GO:0019527 ! pentitol catabolic process
is_a: GO:0051164 ! xylitol metabolic process

[Term]
id: GO:0051161
name: arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "arabitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0051162
name: L-arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
synonym: "L-arabitol metabolism" EXACT []
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051163
name: D-arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
synonym: "D-arabitol metabolism" EXACT []
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051164
name: xylitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai]
comment: Note that xylitol is a meso compound, thus there are no L or D-versions.
synonym: "xylitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0051165
name: 2,5-dihydroxypyridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,5-dihydroxypyridine." [GOC:ai]
synonym: "2,5-dihydroxypyridine metabolism" EXACT []
synonym: "pyridine-2,5-diol metabolic process" EXACT [CHEBI:16364]
is_a: GO:0072524 ! pyridine-containing compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0051166
name: 2,5-dihydroxypyridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [GOC:ai]
synonym: "2,5-dihydroxypyridine breakdown" EXACT []
synonym: "2,5-dihydroxypyridine catabolism" EXACT []
synonym: "2,5-dihydroxypyridine degradation" EXACT []
synonym: "pyridine-2,5-diol catabolic process" EXACT [CHEBI:16364]
is_a: GO:0051165 ! 2,5-dihydroxypyridine metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0051167
name: xylulose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544]
synonym: "D-xylulose 5-phosphate metabolic process" EXACT []
synonym: "D-xylulose 5-phosphate metabolism" EXACT []
synonym: "D-xylulose-5-phosphate metabolic process" EXACT []
synonym: "D-xylulose-5-phosphate metabolism" EXACT []
synonym: "xylulose 5-phosphate metabolism" EXACT []
synonym: "xylulose-5-phosphate metabolic process" EXACT []
synonym: "xylulose-5-phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0051168
name: nuclear export
namespace: biological_process
def: "The directed movement of substances out of the nucleus." [GOC:ai]
synonym: "export from nucleus" EXACT []
synonym: "nucleus export" EXACT []
synonym: "substance nuclear export" EXACT []
is_a: GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0051169
name: nuclear transport
namespace: biological_process
def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai]
subset: goslim_yeast
synonym: "nucleus transport" EXACT []
xref: Wikipedia:Nuclear_transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0051170
name: import into nucleus
namespace: biological_process
alt_id: GO:1902593
def: "The directed movement of substances into the nucleus." [GOC:ai]
synonym: "nuclear import" EXACT []
synonym: "nuclear translocation" EXACT []
is_a: GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0051171
name: obsolete regulation of nitrogen compound metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0019222

[Term]
id: GO:0051172
name: obsolete negative regulation of nitrogen compound metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0009892

[Term]
id: GO:0051173
name: obsolete positive regulation of nitrogen compound metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb]
is_obsolete: true
replaced_by: GO:0019222

[Term]
id: GO:0051174
name: regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]
synonym: "regulation of phosphorus metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0051175
name: negative regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
synonym: "down regulation of sulfur metabolic process" EXACT []
synonym: "down-regulation of sulfur metabolic process" EXACT []
synonym: "downregulation of sulfur metabolic process" EXACT []
synonym: "inhibition of sulfur metabolic process" NARROW []
synonym: "negative regulation of sulfur metabolism" EXACT []
synonym: "negative regulation of sulphur metabolic process" EXACT []
synonym: "negative regulation of sulphur metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: negatively_regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051176
name: positive regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
synonym: "activation of sulfur metabolic process" NARROW []
synonym: "positive regulation of sulfur metabolism" EXACT []
synonym: "positive regulation of sulphur metabolic process" EXACT []
synonym: "positive regulation of sulphur metabolism" EXACT []
synonym: "stimulation of sulfur metabolic process" NARROW []
synonym: "up regulation of sulfur metabolic process" EXACT []
synonym: "up-regulation of sulfur metabolic process" EXACT []
synonym: "upregulation of sulfur metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: positively_regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051177
name: meiotic sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai]
is_a: GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0051178
name: obsolete meiotic chromosome decondensation
namespace: biological_process
def: "OBSOLETE. The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai]
comment: This term was obsoleted because it is a spontaneous process.
is_obsolete: true

[Term]
id: GO:0051179
name: localization
namespace: biological_process
alt_id: GO:1902578
def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "establishment and maintenance of cellular component location" NARROW []
synonym: "establishment and maintenance of localization" EXACT []
synonym: "establishment and maintenance of position" EXACT []
synonym: "establishment and maintenance of substance location" NARROW []
synonym: "establishment and maintenance of substrate location" NARROW []
synonym: "localisation" EXACT [GOC:mah]
synonym: "single organism localization" RELATED [GOC:TermGenie]
synonym: "single-organism localization" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051180
name: vitamin transport
namespace: biological_process
def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_pir
synonym: "vitamin or cofactor transport" BROAD []
is_a: GO:0006810 ! transport

[Term]
id: GO:0051181
name: obsolete cofactor transport
namespace: biological_process
def: "OBSOLETE. The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "vitamin or cofactor transport" BROAD []
is_obsolete: true

[Term]
id: GO:0051182
name: obsolete coenzyme transport
namespace: biological_process
def: "OBSOLETE. The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme.
is_obsolete: true

[Term]
id: GO:0051184
name: obsolete cofactor transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor transporter activity" RELATED []
synonym: "vitamin or cofactor transporter activity" BROAD []
is_obsolete: true

[Term]
id: GO:0051185
name: obsolete coenzyme transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:0051186
name: obsolete cofactor metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0051187
name: obsolete cofactor catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor breakdown" EXACT []
synonym: "cofactor catabolism" EXACT []
synonym: "cofactor degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0051188
name: obsolete cofactor biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor anabolism" EXACT []
synonym: "cofactor biosynthesis" EXACT []
synonym: "cofactor formation" EXACT []
synonym: "cofactor synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0051189
name: prosthetic group metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: goslim_pir
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "prosthetic group metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
relationship: part_of GO:0019538 ! protein metabolic process

[Term]
id: GO:0051190
name: prosthetic group catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
synonym: "coenzyme and prosthetic group catabolic process" BROAD []
synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "prosthetic group breakdown" EXACT []
synonym: "prosthetic group catabolism" EXACT []
synonym: "prosthetic group degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0030163 ! protein catabolic process

[Term]
id: GO:0051191
name: prosthetic group biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
synonym: "coenzyme and prosthetic group biosynthesis" BROAD []
synonym: "coenzyme and prosthetic group biosynthetic process" BROAD []
synonym: "prosthetic group anabolism" EXACT []
synonym: "prosthetic group biosynthesis" EXACT []
synonym: "prosthetic group formation" EXACT []
synonym: "prosthetic group synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0051192
name: prosthetic group binding
namespace: molecular_function
def: "Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai, GOC:vw]
is_a: GO:0005488 ! binding

[Term]
id: GO:0051193
name: obsolete regulation of cofactor metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "regulation of cofactor metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0051194
name: obsolete positive regulation of cofactor metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "activation of cofactor metabolic process" NARROW []
synonym: "positive regulation of cofactor metabolism" EXACT []
synonym: "stimulation of cofactor metabolic process" NARROW []
synonym: "up regulation of cofactor metabolic process" EXACT []
synonym: "up-regulation of cofactor metabolic process" EXACT []
synonym: "upregulation of cofactor metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0051195
name: obsolete negative regulation of cofactor metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "down regulation of cofactor metabolic process" EXACT []
synonym: "down-regulation of cofactor metabolic process" EXACT []
synonym: "downregulation of cofactor metabolic process" EXACT []
synonym: "inhibition of cofactor metabolic process" NARROW []
synonym: "negative regulation of cofactor metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0051196
name: obsolete regulation of coenzyme metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of coenzyme metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0051197
name: obsolete positive regulation of coenzyme metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "activation of coenzyme metabolic process" NARROW []
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "positive regulation of coenzyme metabolism" EXACT []
synonym: "stimulation of coenzyme metabolic process" NARROW []
synonym: "up regulation of coenzyme metabolic process" EXACT []
synonym: "up-regulation of coenzyme metabolic process" EXACT []
synonym: "upregulation of coenzyme metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0051198
name: obsolete negative regulation of coenzyme metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "down regulation of coenzyme metabolic process" EXACT []
synonym: "down-regulation of coenzyme metabolic process" EXACT []
synonym: "downregulation of coenzyme metabolic process" EXACT []
synonym: "inhibition of coenzyme metabolic process" NARROW []
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of coenzyme metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0051199
name: obsolete regulation of prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
comment: This term was obsoleted because it conflates the regulation of a metabolic process and the role of its product.
synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of prosthetic group metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0051200
name: obsolete positive regulation of prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
comment: This term was obsoleted because it conflates the regulation of a metabolic process and the role of its product.
synonym: "activation of prosthetic group metabolic process" NARROW []
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "positive regulation of prosthetic group metabolism" EXACT []
synonym: "stimulation of prosthetic group metabolic process" NARROW []
synonym: "up regulation of prosthetic group metabolic process" EXACT []
synonym: "up-regulation of prosthetic group metabolic process" EXACT []
synonym: "upregulation of prosthetic group metabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:0051201
name: obsolete negative regulation of prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
comment: This term was obsoleted because it conflates the regulation of a metabolic process and the role of its product.
synonym: "down regulation of prosthetic group metabolic process" EXACT []
synonym: "down-regulation of prosthetic group metabolic process" EXACT []
synonym: "downregulation of prosthetic group metabolic process" EXACT []
synonym: "inhibition of prosthetic group metabolic process" NARROW []
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of prosthetic group metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0051202
name: phytochromobilin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553]
synonym: "phytochromobilin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0051203
name: obsolete peptidyl-aspartic acid reduction to form L-aspartyl aldehyde
namespace: biological_process
def: "OBSOLETE. The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde" EXACT []
synonym: "peptidyl-aspartic acid reduction to form L-beta-formylalanine" EXACT []
is_obsolete: true

[Term]
id: GO:0051204
name: protein insertion into mitochondrial membrane
namespace: biological_process
def: "The process that results in the incorporation of a protein into a mitochondrial membrane." [GOC:ai]
synonym: "integral mitochondrial membrane protein localization" EXACT []
synonym: "integral mitochondrial membrane protein positioning" EXACT []
synonym: "localization of protein in mitochondrial membrane" EXACT []
synonym: "positioning of protein in mitochondrial membrane" EXACT []
synonym: "protein insertion into mitochondrion membrane" EXACT []
synonym: "protein-mitochondrial membrane insertion" EXACT []
synonym: "protein-mitochondrion membrane insertion" EXACT []
is_a: GO:0051205 ! protein insertion into membrane
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
relationship: part_of GO:0070585 ! protein localization to mitochondrion

[Term]
id: GO:0051205
name: protein insertion into membrane
namespace: biological_process
def: "The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]
synonym: "integral membrane protein localization" EXACT []
synonym: "integral membrane protein positioning" EXACT []
synonym: "membrane protein localization" EXACT []
synonym: "membrane protein positioning" EXACT []
synonym: "protein-membrane insertion" EXACT []
is_a: GO:0090150 ! establishment of protein localization to membrane
relationship: part_of GO:0008104 ! protein localization
relationship: part_of GO:0061024 ! membrane organization

[Term]
id: GO:0051206
name: silicate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai]
synonym: "silicate metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0051208
name: sequestering of calcium ion
namespace: biological_process
def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "calcium ion (Ca2+) retention" EXACT []
synonym: "calcium ion (Ca2+) sequestering" EXACT []
synonym: "calcium ion (Ca2+) sequestration" EXACT []
synonym: "calcium ion (Ca2+) storage" EXACT []
synonym: "calcium ion storage activity" RELATED []
synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED []
synonym: "retention of calcium ion (Ca2+)" EXACT []
synonym: "sequestering of calcium ion (Ca2+)" EXACT []
synonym: "sequestration of calcium ion (Ca2+)" EXACT []
synonym: "storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0006874 ! intracellular calcium ion homeostasis

[Term]
id: GO:0051209
name: release of sequestered calcium ion into cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]
synonym: "calcium ion (Ca2+) mobilization" BROAD []
synonym: "calcium mobilization" BROAD []
synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "release of stored calcium ion (Ca2+)" BROAD []
synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0051283 ! negative regulation of sequestering of calcium ion
is_a: GO:0097553 ! calcium ion transmembrane import into cytosol

[Term]
id: GO:0051210
name: isotropic cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jid]
synonym: "uniform cell growth" RELATED []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0051211
name: anisotropic cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai]
synonym: "non-isotropic cell growth" EXACT []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0051212
name: vanadium ion binding
namespace: molecular_function
def: "Binding to a vanadium ion (V)." [GOC:ai]
synonym: "V ion binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0051213
name: dioxygenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]
subset: goslim_pir
xref: Reactome:R-HSA-112120 "Oxidative demethylation of 3-meC damaged DNA by ALKBH2"
xref: Reactome:R-HSA-112121 "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2"
xref: Reactome:R-HSA-112124 "Oxidative demethylation of 3-meC damaged DNA By ALKBH3"
xref: Reactome:R-HSA-112125 "Oxidative dealkylation of 1-EtA damaged DNA by ABH3"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051214
name: RNAi-mediated antiviral immunity against RNA virus
namespace: biological_process
def: "An RNAi-mediated post-transcriptional gene silencing pathway induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL4 is the primary Dicer to detect RNA viruses." [PMID:15165191, PMID:17693253]
synonym: "RNA VIGS" EXACT []
synonym: "RNA virus induced gene silencing" EXACT []
synonym: "RNA virus-induced gene silencing" EXACT []
synonym: "RNA virus-induced PTGS" EXACT []
is_a: GO:0009616 ! RNAi-mediated antiviral immune response

[Term]
id: GO:0051215
name: RNAi-mediated antiviral immunity against DNA virus
namespace: biological_process
def: "An RNAi-mediated post-transcriptional gene silencing pathway induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL3 is the primary Dicer to detect DNA viruses." [PMID:15165191, PMID:17693253, PMID:23151511]
synonym: "DNA VIGS" EXACT []
synonym: "DNA virus induced gene silencing" EXACT []
synonym: "DNA virus-induced gene silencing" EXACT []
synonym: "DNA virus-induced PTGS" EXACT []
is_a: GO:0009616 ! RNAi-mediated antiviral immune response

[Term]
id: GO:0051216
name: cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424]
synonym: "cartilage biogenesis" EXACT []
synonym: "cartilage biosynthesis" EXACT []
synonym: "cartilage element development" EXACT []
synonym: "cartilage formation" EXACT []
synonym: "cartilage organ development" EXACT []
synonym: "chondrogenesis" EXACT []
xref: Wikipedia:Chondrogenesis
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0001501 ! skeletal system development
relationship: part_of GO:0061448 ! connective tissue development

[Term]
id: GO:0051217
name: obsolete molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "OBSOLETE. The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051218
name: obsolete tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "OBSOLETE. The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051219
name: phosphoprotein binding
namespace: molecular_function
def: "Binding to a phosphorylated protein." [GOC:ai]
subset: goslim_chembl
synonym: "phosphorylated protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051220
name: obsolete cytoplasmic sequestering of protein
namespace: biological_process
def: "OBSOLETE. The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "cytoplasmic retention of protein" EXACT []
synonym: "cytoplasmic sequestration of protein" EXACT []
synonym: "cytoplasmic storage of protein" EXACT []
synonym: "maintenance of protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of protein in cytoplasm" EXACT []
synonym: "sequestering of protein in cytoplasm" EXACT []
synonym: "sequestration of protein in cytoplasm" EXACT []
synonym: "storage of protein in cytoplasm" EXACT []
is_obsolete: true

[Term]
id: GO:0051221
name: obsolete tungsten incorporation into metallo-sulfur cluster
namespace: biological_process
def: "OBSOLETE. The incorporation of tungsten into a metallo-sulfur cluster." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "tungsten incorporation into metallo-sulphur cluster" EXACT []
is_obsolete: true

[Term]
id: GO:0051222
name: positive regulation of protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of protein transport" NARROW []
synonym: "stimulation of protein transport" NARROW []
synonym: "up regulation of protein transport" EXACT []
synonym: "up-regulation of protein transport" EXACT []
synonym: "upregulation of protein transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1904951 ! positive regulation of establishment of protein localization
relationship: positively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051223
name: regulation of protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0070201 ! regulation of establishment of protein localization
relationship: regulates GO:0015031 ! protein transport

[Term]
id: GO:0051224
name: negative regulation of protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of protein transport" EXACT []
synonym: "down-regulation of protein transport" EXACT []
synonym: "downregulation of protein transport" EXACT []
synonym: "inhibition of protein transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1904950 ! negative regulation of establishment of protein localization
relationship: negatively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051225
name: spindle assembly
namespace: biological_process
alt_id: GO:0051226
alt_id: GO:0051227
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
synonym: "bipolar spindle biosynthesis" EXACT []
synonym: "bipolar spindle formation" EXACT []
synonym: "spindle biosynthesis" EXACT []
synonym: "spindle formation" EXACT []
is_a: GO:0007051 ! spindle organization
is_a: GO:0140694 ! membraneless organelle assembly
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0051228
name: mitotic spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai]
synonym: "mitotic spindle breakdown" EXACT []
synonym: "mitotic spindle catabolism" EXACT []
synonym: "mitotic spindle degradation" EXACT []
synonym: "spindle breakdown during mitosis" EXACT []
synonym: "spindle degradation during mitosis" EXACT []
synonym: "spindle disassembly during mitosis" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
is_a: GO:0051230 ! spindle disassembly

[Term]
id: GO:0051229
name: meiotic spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai]
synonym: "meiotic spindle breakdown" EXACT []
synonym: "meiotic spindle catabolism" EXACT []
synonym: "meiotic spindle degradation" EXACT []
synonym: "spindle breakdown during meiosis" EXACT []
synonym: "spindle degradation during meiosis" EXACT []
synonym: "spindle disassembly during meiosis" EXACT []
is_a: GO:0000212 ! meiotic spindle organization
is_a: GO:0051230 ! spindle disassembly

[Term]
id: GO:0051230
name: spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai]
synonym: "spindle breakdown" EXACT []
synonym: "spindle catabolism" EXACT []
synonym: "spindle degradation" EXACT []
is_a: GO:0007051 ! spindle organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0051231
name: spindle elongation
namespace: biological_process
def: "The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007051 ! spindle organization
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0051232
name: meiotic spindle elongation
namespace: biological_process
def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai]
synonym: "spindle elongation during meiosis" EXACT []
is_a: GO:0051231 ! spindle elongation
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0000212 ! meiotic spindle organization
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051233
name: spindle midzone
namespace: cellular_component
def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
synonym: "central spindle" EXACT [PMID:14528012]
synonym: "spindle equator" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0051235
name: maintenance of location
namespace: biological_process
def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of localization" EXACT []
synonym: "retention" NARROW []
synonym: "sequestering" NARROW []
synonym: "storage" NARROW []
is_a: GO:0051179 ! localization

[Term]
id: GO:0051236
name: establishment of RNA localization
namespace: biological_process
def: "The directed movement of RNA to a specific location." [GOC:ai]
synonym: "establishment of RNA localisation" EXACT [GOC:mah]
synonym: "RNA positioning" EXACT []
synonym: "RNA recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0006403 ! RNA localization

[Term]
id: GO:0051237
name: maintenance of RNA location
namespace: biological_process
def: "Any process in which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai]
synonym: "maintenance of RNA localization" RELATED [GOC:dph, GOC:tb]
synonym: "RNA retention" EXACT []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0006403 ! RNA localization

[Term]
id: GO:0051238
name: obsolete sequestering of metal ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "metal ion retention" EXACT []
synonym: "metal ion sequestering" EXACT []
synonym: "metal ion sequestration" EXACT []
synonym: "metal ion storage" EXACT []
synonym: "retention of metal ion" EXACT []
synonym: "sequestration of metal ion" EXACT []
synonym: "storage of metal ion" EXACT []
is_obsolete: true
replaced_by: GO:0140487

[Term]
id: GO:0051239
name: regulation of multicellular organismal process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051240
name: positive regulation of multicellular organismal process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "activation of multicellular organismal process" NARROW []
synonym: "stimulation of multicellular organismal process" NARROW []
synonym: "up regulation of multicellular organismal process" EXACT []
synonym: "up-regulation of multicellular organismal process" EXACT []
synonym: "upregulation of multicellular organismal process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: positively_regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051241
name: negative regulation of multicellular organismal process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "down regulation of multicellular organismal process" EXACT []
synonym: "down-regulation of multicellular organismal process" EXACT []
synonym: "downregulation of multicellular organismal process" EXACT []
synonym: "inhibition of multicellular organismal process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: negatively_regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051245
name: negative regulation of cellular defense response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai]
synonym: "down regulation of cellular defense response" EXACT []
synonym: "down-regulation of cellular defense response" EXACT []
synonym: "downregulation of cellular defense response" EXACT []
synonym: "inhibition of cellular defense response" NARROW []
synonym: "negative regulation of cellular defence response" EXACT []
is_a: GO:0010185 ! regulation of cellular defense response
is_a: GO:0031348 ! negative regulation of defense response
relationship: negatively_regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0051246
name: regulation of protein metabolic process
namespace: biological_process
alt_id: GO:0032268
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "regulation of cellular protein metabolic process" RELATED []
synonym: "regulation of cellular protein metabolism" RELATED []
synonym: "regulation of protein metabolism" EXACT []
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051247
name: positive regulation of protein metabolic process
namespace: biological_process
alt_id: GO:0032270
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "activation of cellular protein metabolic process" NARROW []
synonym: "activation of protein metabolic process" NARROW []
synonym: "positive regulation of cellular protein metabolic process" EXACT []
synonym: "positive regulation of cellular protein metabolism" EXACT []
synonym: "positive regulation of protein metabolism" EXACT []
synonym: "stimulation of cellular protein metabolic process" NARROW []
synonym: "stimulation of protein metabolic process" NARROW []
synonym: "up regulation of cellular protein metabolic process" EXACT []
synonym: "up regulation of protein metabolic process" EXACT []
synonym: "up-regulation of cellular protein metabolic process" EXACT []
synonym: "up-regulation of protein metabolic process" EXACT []
synonym: "upregulation of cellular protein metabolic process" EXACT []
synonym: "upregulation of protein metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: positively_regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051248
name: negative regulation of protein metabolic process
namespace: biological_process
alt_id: GO:0032269
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "down regulation of cellular protein metabolic process" EXACT []
synonym: "down regulation of protein metabolic process" EXACT []
synonym: "down-regulation of cellular protein metabolic process" EXACT []
synonym: "down-regulation of protein metabolic process" EXACT []
synonym: "downregulation of cellular protein metabolic process" EXACT []
synonym: "downregulation of protein metabolic process" EXACT []
synonym: "inhibition of cellular protein metabolic process" NARROW []
synonym: "inhibition of protein metabolic process" NARROW []
synonym: "negative regulation of cellular protein metabolic process" EXACT []
synonym: "negative regulation of cellular protein metabolism" EXACT []
synonym: "negative regulation of protein metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: negatively_regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051249
name: regulation of lymphocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051250
name: negative regulation of lymphocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "down regulation of lymphocyte activation" EXACT []
synonym: "down-regulation of lymphocyte activation" EXACT []
synonym: "downregulation of lymphocyte activation" EXACT []
synonym: "inhibition of lymphocyte activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: negatively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051251
name: positive regulation of lymphocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "activation of lymphocyte activation" NARROW []
synonym: "stimulation of lymphocyte activation" NARROW []
synonym: "up regulation of lymphocyte activation" EXACT []
synonym: "up-regulation of lymphocyte activation" EXACT []
synonym: "upregulation of lymphocyte activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: positively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051252
name: regulation of RNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "regulation of RNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051253
name: negative regulation of RNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "down regulation of RNA metabolic process" EXACT []
synonym: "down-regulation of RNA metabolic process" EXACT []
synonym: "downregulation of RNA metabolic process" EXACT []
synonym: "inhibition of RNA metabolic process" NARROW []
synonym: "negative regulation of RNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: negatively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051254
name: positive regulation of RNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "activation of RNA metabolic process" NARROW []
synonym: "positive regulation of RNA metabolism" EXACT []
synonym: "stimulation of RNA metabolic process" NARROW []
synonym: "up regulation of RNA metabolic process" EXACT []
synonym: "up-regulation of RNA metabolic process" EXACT []
synonym: "upregulation of RNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: positively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051255
name: spindle midzone assembly
namespace: biological_process
def: "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
synonym: "spindle midzone biogenesis" EXACT []
synonym: "spindle midzone biosynthesis" EXACT []
synonym: "spindle midzone formation" EXACT []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0051225 ! spindle assembly

[Term]
id: GO:0051256
name: mitotic spindle midzone assembly
namespace: biological_process
def: "The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120]
synonym: "mitotic spindle midzone biogenesis" EXACT []
synonym: "mitotic spindle midzone biosynthesis" EXACT []
synonym: "mitotic spindle midzone formation" EXACT []
synonym: "spindle midzone assembly involved in mitosis" EXACT []
synonym: "spindle midzone biogenesis involved in mitosis" EXACT []
synonym: "spindle midzone formation involved in mitosis" EXACT []
is_a: GO:0051255 ! spindle midzone assembly
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000022 ! mitotic spindle elongation
relationship: part_of GO:0090307 ! mitotic spindle assembly

[Term]
id: GO:0051257
name: meiotic spindle midzone assembly
namespace: biological_process
def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb]
synonym: "meiotic spindle midzone biogenesis" EXACT []
synonym: "meiotic spindle midzone biosynthesis" EXACT []
synonym: "meiotic spindle midzone formation" EXACT []
synonym: "spindle midzone assembly involved in meiosis" EXACT []
synonym: "spindle midzone biogenesis involved in meiosis" EXACT []
synonym: "spindle midzone biosynthesis involved in meiosis" EXACT []
synonym: "spindle midzone formation involved in meiosis" EXACT []
is_a: GO:0051255 ! spindle midzone assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0051258
name: protein polymerization
namespace: biological_process
def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
synonym: "protein polymer biosynthesis" EXACT []
synonym: "protein polymer biosynthetic process" EXACT []
synonym: "protein polymer formation" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0051259
name: protein complex oligomerization
namespace: biological_process
alt_id: GO:0035786
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929]
synonym: "protein multimerization" RELATED [GOC:bf]
synonym: "protein oligomer assembly" EXACT []
synonym: "protein oligomer biosynthesis" BROAD []
synonym: "protein oligomer biosynthetic process" BROAD []
synonym: "protein oligomer formation" EXACT []
synonym: "protein oligomerization" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0051260
name: protein homooligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
synonym: "protein homooligomer assembly" EXACT []
synonym: "protein homooligomer biosynthesis" EXACT []
synonym: "protein homooligomer biosynthetic process" EXACT []
synonym: "protein homooligomer formation" EXACT []
synonym: "protein homooligomerization activity" RELATED []
is_a: GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0051261
name: protein depolymerization
namespace: biological_process
def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
synonym: "protein polymer breakdown" EXACT []
synonym: "protein polymer catabolic process" EXACT []
synonym: "protein polymer catabolism" EXACT []
synonym: "protein polymer degradation" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0051262
name: protein tetramerization
namespace: biological_process
def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]
synonym: "protein tetramer assembly" EXACT []
synonym: "protein tetramer biosynthesis" EXACT []
synonym: "protein tetramer biosynthetic process" EXACT []
synonym: "protein tetramer formation" EXACT []
is_a: GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0051263
name: obsolete microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine
namespace: biological_process
def: "OBSOLETE. The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374]
comment: This term was obsoleted because it represents a molecular function.
synonym: "microcin E492 anabolism by siderophore ester modification of peptidyl-serine" EXACT []
synonym: "microcin E492 formation by siderophore ester modification of peptidyl-serine" EXACT []
synonym: "microcin E492 synthesis by siderophore ester modification of peptidyl-serine" EXACT []
is_obsolete: true

[Term]
id: GO:0051264
name: mono-olein transacylation activity
namespace: molecular_function
def: "Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol." [GOC:ai, PMID:15364929]
synonym: "acyl-CoA-independent mono-olein transacylation" EXACT []
synonym: "MOG transacylation" EXACT []
synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT []
synonym: "mono-oleoylglycerol transacylase activity" EXACT []
synonym: "monoolein transacylation" EXACT []
synonym: "monooleoylglycerol O-acyltransferase activity" EXACT []
synonym: "monooleoylglycerol transacylase activity" EXACT []
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0051265
name: diolein transacylation activity
namespace: molecular_function
def: "Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein." [GOC:ai, PMID:15364929]
synonym: "acyl-CoA-independent diolein transacylation" EXACT []
synonym: "dioleoylglycerol O-acyltransferase activity" EXACT []
synonym: "dioleoylglycerol transacylase activity" EXACT []
synonym: "DOG transacylation" EXACT []
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0051266
name: sirohydrochlorin ferrochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin." [RHEA:24360]
synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" RELATED []
synonym: "siroheme synthase activity" BROAD []
synonym: "sirohydrochlorin ferro-lyase activity" EXACT []
xref: EC:4.99.1.4
xref: KEGG_REACTION:R02864
xref: MetaCyc:SIROHEME-FERROCHELAT-RXN
xref: RHEA:24360
is_a: GO:0004325 ! ferrochelatase activity

[Term]
id: GO:0051267
name: CP2 mannose-ethanolamine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-phosphate-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134]
synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT []
synonym: "CP2 ethanolamine phosphate transferase activity" EXACT []
synonym: "CP2 EtN-P transferase activity" EXACT []
synonym: "CP2 phosphoethanolamine transferase activity" EXACT []
synonym: "gpi7 activity" RELATED []
is_a: GO:0051377 ! mannose-ethanolamine phosphotransferase activity

[Term]
id: GO:0051268
name: alpha-keto amide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669]
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0051269
name: alpha-ketoester reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-ketoester + H+ + NADPH = (R)-hydroxy ester + NADP+." [PMID:15564669]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0051270
name: obsolete regulation of cellular component movement
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
comment: This term was obsoleted because it was not a useful grouping class since it mixed both cell and cellular component terms.
synonym: "regulation of cell movement" RELATED []
synonym: "regulation of cellular component motion" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0051271
name: obsolete negative regulation of cellular component movement
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
comment: This term was obsoleted because it was not a useful grouping class since it mixed both cell and cellular component terms.
synonym: "negative regulation of cellular component motion" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0051272
name: obsolete positive regulation of cellular component movement
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
comment: This term was obsoleted because it was not a useful grouping class since it mixed both cell and cellular component terms.
synonym: "positive regulation of cellular component motion" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0051273
name: beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai]
synonym: "beta-glucan metabolism" EXACT []
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0051274
name: beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans." [GOC:ai]
synonym: "beta-glucan anabolism" EXACT []
synonym: "beta-glucan biosynthesis" EXACT []
synonym: "beta-glucan formation" EXACT []
synonym: "beta-glucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0051275
name: beta-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans." [GOC:ai]
synonym: "beta-glucan breakdown" EXACT []
synonym: "beta-glucan catabolism" EXACT []
synonym: "beta-glucan degradation" EXACT []
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0051276
name: chromosome organization
namespace: biological_process
alt_id: GO:0006323
alt_id: GO:0007001
alt_id: GO:0051277
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
synonym: "chromosome organisation" EXACT []
synonym: "chromosome organization and biogenesis" RELATED [GOC:mah]
synonym: "DNA condensation" EXACT []
synonym: "DNA packaging" NARROW []
synonym: "maintenance of genome integrity" RELATED []
synonym: "nuclear genome maintenance" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0051278
name: fungal-type cell wall polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu]
synonym: "cell wall polysaccharide anabolism" BROAD []
synonym: "cell wall polysaccharide formation" BROAD []
synonym: "cell wall polysaccharide synthesis" BROAD []
synonym: "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process" NARROW []
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0051279
name: regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb]
synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT []
synonym: "regulation of calcium mobilization" EXACT []
synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT []
synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT []
synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0051282 ! regulation of sequestering of calcium ion
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051280
name: negative regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]
synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW []
synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD []
synonym: "negative regulation of calcium mobilization" BROAD []
synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:0051284 ! positive regulation of sequestering of calcium ion
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051281
name: positive regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]
synonym: "activation of release of sequestered calcium ion into cytosol" NARROW []
synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD []
synonym: "positive regulation of calcium mobilization" BROAD []
synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW []
synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT []
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051282
name: regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "regulation of storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051283
name: negative regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "down regulation of sequestering of calcium ion" EXACT []
synonym: "down-regulation of sequestering of calcium ion" EXACT []
synonym: "downregulation of sequestering of calcium ion" EXACT []
synonym: "inhibition of sequestering of calcium ion" NARROW []
synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051282 ! regulation of sequestering of calcium ion
relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051284
name: positive regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "activation of sequestering of calcium ion" NARROW []
synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT []
synonym: "stimulation of sequestering of calcium ion" NARROW []
synonym: "up regulation of sequestering of calcium ion" EXACT []
synonym: "up-regulation of sequestering of calcium ion" EXACT []
synonym: "upregulation of sequestering of calcium ion" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051282 ! regulation of sequestering of calcium ion
relationship: positively_regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051285
name: cell cortex of cell tip
namespace: cellular_component
def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai]
synonym: "cell cortex of cell end" EXACT []
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0051286
name: cell tip
namespace: cellular_component
def: "The region at the end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah]
comment: Note that this term differs from 'cell pole ; GO:0060187' in that it is applicable to the thin ends of elongated cells, such as the ends of axons or dendrites.
synonym: "cell end" EXACT [GOC:mah]
is_a: GO:0060187 ! cell pole

[Term]
id: GO:0051287
name: NAD binding
namespace: molecular_function
alt_id: GO:0051288
def: "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
subset: goslim_chembl
synonym: "NAD or NADH binding" RELATED [GOC:mah]
synonym: "NAD+ or NADH binding" RELATED []
synonym: "nicotinamide adenine dinucleotide binding" EXACT []
is_a: GO:0030554 ! adenyl nucleotide binding

[Term]
id: GO:0051289
name: protein homotetramerization
namespace: biological_process
def: "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]
synonym: "protein homotetramer assembly" EXACT []
synonym: "protein homotetramer biosynthesis" EXACT []
synonym: "protein homotetramer biosynthetic process" EXACT []
synonym: "protein homotetramer formation" EXACT []
is_a: GO:0051260 ! protein homooligomerization
is_a: GO:0051262 ! protein tetramerization

[Term]
id: GO:0051290
name: protein heterotetramerization
namespace: biological_process
def: "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical." [GOC:go_curators]
synonym: "protein heterotetramer assembly" EXACT []
synonym: "protein heterotetramer biosynthesis" EXACT []
synonym: "protein heterotetramer biosynthetic process" EXACT []
synonym: "protein heterotetramer formation" EXACT []
is_a: GO:0051262 ! protein tetramerization
is_a: GO:0051291 ! protein heterooligomerization

[Term]
id: GO:0051291
name: protein heterooligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
synonym: "protein heterooligomer assembly" EXACT []
synonym: "protein heterooligomer biosynthesis" EXACT []
synonym: "protein heterooligomer biosynthetic process" EXACT []
synonym: "protein heterooligomer formation" EXACT []
is_a: GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0051292
name: nuclear pore complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]
synonym: "NPC assembly" EXACT []
synonym: "nuclear pore assembly" EXACT []
synonym: "nuclear pore biogenesis" EXACT []
synonym: "nuclear pore biosynthesis" EXACT []
synonym: "nuclear pore complex biogenesis" EXACT []
synonym: "nuclear pore complex biosynthesis" EXACT []
synonym: "nuclear pore complex formation" EXACT []
synonym: "nuclear pore formation" EXACT []
is_a: GO:0006999 ! nuclear pore organization
is_a: GO:0046931 ! pore complex assembly

[Term]
id: GO:0051293
name: establishment of spindle localization
namespace: biological_process
def: "The directed movement of the spindle to a specific location in the cell." [GOC:ai]
synonym: "establishment of spindle localisation" EXACT [GOC:mah]
synonym: "spindle positioning" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051653 ! spindle localization
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051294
name: establishment of spindle orientation
namespace: biological_process
def: "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai]
synonym: "orienting of spindle" EXACT []
synonym: "spindle orientation" EXACT []
is_a: GO:0051293 ! establishment of spindle localization
relationship: part_of GO:0030010 ! establishment of cell polarity

[Term]
id: GO:0051295
name: establishment of meiotic spindle localization
namespace: biological_process
def: "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]
synonym: "establishment of meiotic spindle localisation" EXACT [GOC:mah]
synonym: "meiotic spindle positioning" EXACT []
synonym: "spindle positioning during meiosis" RELATED []
synonym: "spindle positioning involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051293 ! establishment of spindle localization
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0051296
name: establishment of meiotic spindle orientation
namespace: biological_process
def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai]
synonym: "establishment of spindle orientation during meiosis" RELATED []
synonym: "establishment of spindle orientation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "meiotic spindle orientation" EXACT []
synonym: "orienting of meiotic spindle" EXACT []
is_a: GO:0051294 ! establishment of spindle orientation
is_a: GO:0051295 ! establishment of meiotic spindle localization

[Term]
id: GO:0051298
name: centrosome duplication
namespace: biological_process
def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
synonym: "centrosome replication" EXACT []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007098 ! centrosome cycle

[Term]
id: GO:0051299
name: centrosome separation
namespace: biological_process
def: "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007098 ! centrosome cycle

[Term]
id: GO:0051300
name: spindle pole body organization
namespace: biological_process
alt_id: GO:0051426
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "SPB maturation" RELATED [GOC:vw]
synonym: "SPB organization" EXACT []
synonym: "spindle pole body maturation" RELATED [GOC:vw]
synonym: "spindle pole body organisation" EXACT []
synonym: "spindle pole body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0051301
name: cell division
namespace: biological_process
def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
xref: Wikipedia:Cell_division
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0051302
name: regulation of cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051301 ! cell division

[Term]
id: GO:0051303
name: establishment of chromosome localization
namespace: biological_process
def: "The directed movement of a chromosome to a specific location." [GOC:ai]
synonym: "chromosome positioning" EXACT []
synonym: "establishment of chromosome localisation" EXACT [GOC:mah]
is_a: GO:0050000 ! chromosome localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051304
name: chromosome separation
namespace: biological_process
alt_id: GO:0034500
def: "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]
synonym: "chromatid release" RELATED [GOC:lb, GOC:mah, PMID:20352243]
synonym: "rDNA separation" NARROW []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0051305
name: chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai]
synonym: "chromosome migration to spindle pole" EXACT []
synonym: "chromosome movement" BROAD []
synonym: "chromosome movement to spindle pole" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0022402 ! cell cycle process
is_a: GO:0050000 ! chromosome localization
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0051306
name: mitotic sister chromatid separation
namespace: biological_process
def: "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai]
synonym: "chromosome separation during mitosis" RELATED []
synonym: "mitotic chromosome separation" RELATED []
synonym: "mitotic sister chromatid resolution" EXACT [GOC:mah]
synonym: "sister chromatid separation during mitosis" EXACT []
is_a: GO:0051304 ! chromosome separation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0051307
name: meiotic chromosome separation
namespace: biological_process
def: "The process in which chromosomes are physically detached from each other during meiosis." [GOC:ai]
synonym: "chromosome separation during meiosis" EXACT []
synonym: "meiotic chromosome resolution" EXACT [GOC:mah]
is_a: GO:0051304 ! chromosome separation
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051308
name: male meiosis chromosome separation
namespace: biological_process
def: "The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]
synonym: "chromosome separation during male meiosis" EXACT []
synonym: "male meiosis chromosome resolution" EXACT [GOC:mah]
is_a: GO:0007060 ! male meiosis chromosome segregation
is_a: GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0051309
name: female meiosis chromosome separation
namespace: biological_process
def: "The process in which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai]
synonym: "chromosome separation during female meiosis" EXACT []
synonym: "female meiosis chromosome resolution" EXACT [GOC:mah]
is_a: GO:0016321 ! female meiosis chromosome segregation
is_a: GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0051310
name: metaphase chromosome alignment
namespace: biological_process
def: "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [GOC:vw]
synonym: "chromosome congression" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0051311
name: meiotic metaphase chromosome alignment
namespace: biological_process
def: "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during meiotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [GOC:vw]
synonym: "metaphase plate congression during meiosis" EXACT []
is_a: GO:0051310 ! metaphase chromosome alignment
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051312
name: obsolete chromosome decondensation
namespace: biological_process
def: "OBSOLETE. The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai]
comment: This term was obsoleted because it is a spontaneous process.
is_obsolete: true

[Term]
id: GO:0051315
name: attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
alt_id: GO:0051314
def: "The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]
comment: This class covers transient, lateral attachment to microtubules as well as stable, correctly oriented, end-on attachment (biorientation)
synonym: "attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "attachment of spindle microtubules to mitotic chromosome" EXACT []
synonym: "mitotic bipolar attachment" RELATED [GOC:vw]
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007080 ! mitotic metaphase chromosome alignment

[Term]
id: GO:0051316
name: attachment of meiotic spindle microtubules to kinetochore
namespace: biological_process
alt_id: GO:0051317
def: "The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis." [GOC:ai, GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED []
synonym: "attachment of spindle microtubules to kinetochore during meiotic chromosome segregation" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to meiotic chromosome" EXACT []
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0051311 ! meiotic metaphase chromosome alignment

[Term]
id: GO:0051318
name: G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:G1_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051319
name: G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:G2_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051320
name: S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "S-phase" EXACT []
xref: Wikipedia:S_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051321
name: meiotic cell cycle
namespace: biological_process
alt_id: GO:0007126
def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]
comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
subset: goslim_drosophila
subset: goslim_yeast
synonym: "meiosis" RELATED []
xref: Wikipedia:Meiosis
is_a: GO:0007049 ! cell cycle
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0051322
name: anaphase
namespace: biological_process
def: "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Anaphase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051323
name: metaphase
namespace: biological_process
def: "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Metaphase
is_a: GO:0098762 ! meiotic cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051324
name: prophase
namespace: biological_process
def: "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Prophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051325
name: interphase
namespace: biological_process
def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "karyostasis" EXACT []
synonym: "resting phase" BROAD []
xref: Wikipedia:Interphase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0051326
name: telophase
namespace: biological_process
def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Telophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051327
name: meiotic M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M phase of meiotic cell cycle" EXACT []
is_a: GO:0000279 ! M phase
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0051328
name: meiotic interphase
namespace: biological_process
def: "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "interphase of meiotic cell cycle" EXACT []
is_a: GO:0051325 ! interphase
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0051329
name: mitotic interphase
namespace: biological_process
def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "interphase of mitotic cell cycle" EXACT []
is_a: GO:0051325 ! interphase
is_a: GO:0098763 ! mitotic cell cycle phase

[Term]
id: GO:0051330
name: meiotic G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G1 phase of meiotic cell cycle" EXACT []
is_a: GO:0051318 ! G1 phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051331
name: meiotic G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G2 phase of meiotic cell cycle" EXACT []
is_a: GO:0051319 ! G2 phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051332
name: meiotic S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "premeiotic S-phase" EXACT []
synonym: "S phase of meiotic cell cycle" EXACT []
synonym: "S-phase of meiotic cell cycle" EXACT []
is_a: GO:0051320 ! S phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051333
name: meiotic nuclear membrane reassembly
namespace: biological_process
def: "The cell cycle process in which the reformation of the nuclear membranes during meiosis occurs." [GOC:ai]
synonym: "meiotic nuclear envelope reassembly" RELATED []
is_a: GO:0031468 ! nuclear membrane reassembly
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0051334
name: meiosis I nuclear membrane reassembly
namespace: biological_process
def: "The reformation of the nuclear membranes during meiosis I." [GOC:ai]
synonym: "meiosis I nuclear envelope reassembly" RELATED []
is_a: GO:0051333 ! meiotic nuclear membrane reassembly
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0051335
name: meiosis II nuclear membrane reassembly
namespace: biological_process
def: "The reformation of the nuclear membrane during meiosis II." [GOC:ai]
synonym: "meiosis II nuclear envelope reassembly" RELATED []
is_a: GO:0051333 ! meiotic nuclear membrane reassembly
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0051336
name: regulation of hydrolase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "hydrolase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051337
name: amitosis
namespace: biological_process
def: "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [GOC:curators, ISBN:0721662544]
synonym: "direct nuclear division" EXACT []
synonym: "Remak nuclear division" EXACT []
is_a: GO:0000280 ! nuclear division

[Term]
id: GO:0051338
name: regulation of transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_obsoletion_candidate
synonym: "transferase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051339
name: regulation of lyase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "lyase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051340
name: regulation of ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "ligase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051341
name: regulation of oxidoreductase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "oxidoreductase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051342
name: regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "3',5' cyclic nucleotide phosphodiesterase regulator" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase regulator" NARROW []
synonym: "cAMP phosphodiesterase regulator" NARROW []
synonym: "phosphodiesterase regulator" RELATED []
synonym: "regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051343
name: positive regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "3',5' cyclic nucleotide phosphodiesterase activator" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase activator" NARROW []
synonym: "activation of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "cAMP phosphodiesterase activator" NARROW []
synonym: "phosphodiesterase activator" RELATED []
synonym: "positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "positive regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "positive regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "positive regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
synonym: "stimulation of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "up regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "up-regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "upregulation of cyclic nucleotide phosphodiesterase activity" EXACT []
is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0051344
name: negative regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "3',5' cyclic nucleotide phosphodiesterase inhibitor" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase inhibitor" NARROW []
synonym: "cAMP phosphodiesterase inhibitor" NARROW []
synonym: "down regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "down-regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "downregulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "inhibition of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "negative regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "negative regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "negative regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
synonym: "phosphodiesterase inhibitor" RELATED []
is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0051345
name: positive regulation of hydrolase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of hydrolase activity" NARROW []
synonym: "hydrolase activator" EXACT []
synonym: "stimulation of hydrolase activity" NARROW []
synonym: "up regulation of hydrolase activity" EXACT []
synonym: "up-regulation of hydrolase activity" EXACT []
synonym: "upregulation of hydrolase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051346
name: negative regulation of hydrolase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of hydrolase activity" EXACT []
synonym: "down-regulation of hydrolase activity" EXACT []
synonym: "downregulation of hydrolase activity" EXACT []
synonym: "hydrolase inhibitor" EXACT []
synonym: "inhibition of hydrolase activity" NARROW []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051347
name: positive regulation of transferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_obsoletion_candidate
synonym: "activation of transferase activity" NARROW []
synonym: "stimulation of transferase activity" NARROW []
synonym: "transferase activator" EXACT []
synonym: "up regulation of transferase activity" EXACT []
synonym: "up-regulation of transferase activity" EXACT []
synonym: "upregulation of transferase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0051348
name: negative regulation of transferase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_obsoletion_candidate
synonym: "down regulation of transferase activity" EXACT []
synonym: "down-regulation of transferase activity" EXACT []
synonym: "downregulation of transferase activity" EXACT []
synonym: "inhibition of transferase activity" NARROW []
synonym: "transferase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0051349
name: positive regulation of lyase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of lyase activity" NARROW []
synonym: "lyase activator" EXACT []
synonym: "stimulation of lyase activity" NARROW []
synonym: "up regulation of lyase activity" EXACT []
synonym: "up-regulation of lyase activity" EXACT []
synonym: "upregulation of lyase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0051350
name: negative regulation of lyase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of lyase activity" EXACT []
synonym: "down-regulation of lyase activity" EXACT []
synonym: "downregulation of lyase activity" EXACT []
synonym: "inhibition of lyase activity" NARROW []
synonym: "lyase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0051351
name: positive regulation of ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of ligase activity" NARROW []
synonym: "ligase activator" EXACT []
synonym: "stimulation of ligase activity" NARROW []
synonym: "up regulation of ligase activity" EXACT []
synonym: "up-regulation of ligase activity" EXACT []
synonym: "upregulation of ligase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:0051352
name: negative regulation of ligase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of ligase activity" EXACT []
synonym: "down-regulation of ligase activity" EXACT []
synonym: "downregulation of ligase activity" EXACT []
synonym: "inhibition of ligase activity" NARROW []
synonym: "ligase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:0051353
name: positive regulation of oxidoreductase activity
namespace: biological_process
alt_id: GO:0009391
def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "activation of oxidoreductase activity" NARROW []
synonym: "oxidoreductase activator" EXACT []
synonym: "ribonucleotide reductase activating enzyme activity" NARROW []
synonym: "stimulation of oxidoreductase activity" NARROW []
synonym: "up regulation of oxidoreductase activity" EXACT []
synonym: "up-regulation of oxidoreductase activity" EXACT []
synonym: "upregulation of oxidoreductase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0051354
name: negative regulation of oxidoreductase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of oxidoreductase activity" EXACT []
synonym: "down-regulation of oxidoreductase activity" EXACT []
synonym: "downregulation of oxidoreductase activity" EXACT []
synonym: "inhibition of oxidoreductase activity" NARROW []
synonym: "oxidoreductase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0051355
name: proprioception involved in equilibrioception
namespace: biological_process
def: "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]
synonym: "equilibrioception by proprioception" EXACT []
synonym: "perception of orientation with respect to gravity by proprioception" EXACT []
synonym: "proprioception during equilibrioception" RELATED [GOC:dph, GOC:tb]
is_a: GO:0019230 ! proprioception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0051356
name: visual perception involved in equilibrioception
namespace: biological_process
def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]
synonym: "equilibrioception by visual perception" NARROW []
synonym: "perception of orientation with respect to gravity by visual perception" EXACT []
synonym: "visual perception during equilibrioception" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007601 ! visual perception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0051357
name: obsolete peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one
namespace: biological_process
def: "OBSOLETE. The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT []
xref: RESID:AA0377
is_obsolete: true

[Term]
id: GO:0051358
name: obsolete peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT []
xref: RESID:AA0378
is_obsolete: true

[Term]
id: GO:0051359
name: obsolete peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0379
is_obsolete: true

[Term]
id: GO:0051360
name: obsolete peptide cross-linking via L-asparagine 5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0380
is_obsolete: true

[Term]
id: GO:0051361
name: obsolete peptide cross-linking via L-lysine 5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0381
is_obsolete: true

[Term]
id: GO:0051362
name: obsolete peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine
namespace: biological_process
def: "OBSOLETE. The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382]
comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined in RESID.
synonym: "biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0382
is_obsolete: true

[Term]
id: GO:0051363
name: obsolete peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein
namespace: biological_process
def: "OBSOLETE. The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [PMID:8163519, PMID:9086265, RESID:AA0383]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051364
name: obsolete N-terminal peptidyl-proline N-formylation
namespace: biological_process
def: "OBSOLETE. The formylation of the N-terminal proline of proteins to form the derivative N-formylproline." [PMID:12051774, PMID:5464655, RESID:AA0384]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051365
name: cellular response to potassium ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions." [GOC:sm]
synonym: "cellular response to K+ ion deprivation" EXACT []
synonym: "cellular response to K+ ion starvation" EXACT []
synonym: "cellular response to potassium ion deprivation" EXACT []
synonym: "cellular response to potassium starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0051366
name: protein decanoylation
namespace: biological_process
def: "The modification of a protein amino acid by formation of an ester or amide with decanoic acid." [GOC:jsg]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid decanoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0051367
name: obsolete peptidyl-serine decanoylation
namespace: biological_process
def: "OBSOLETE. The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin." [GOC:jsg, PMID:12630926, RESID:AA0385]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051368
name: obsolete peptidyl-threonine octanoylation
namespace: biological_process
def: "OBSOLETE. The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051369
name: obsolete peptidyl-threonine decanoylation
namespace: biological_process
def: "OBSOLETE. The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051370
name: obsolete ZASP binding
namespace: molecular_function
def: "OBSOLETE. Binding to Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT []
synonym: "ZASP binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051371
name: muscle alpha-actinin binding
namespace: molecular_function
def: "Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165]
synonym: "alpha-actinin 2 binding" NARROW []
synonym: "alpha-actinin 3 binding" NARROW []
is_a: GO:0051393 ! alpha-actinin binding

[Term]
id: GO:0051373
name: FATZ binding
namespace: molecular_function
alt_id: GO:0051374
alt_id: GO:0051375
alt_id: GO:0051376
def: "Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871]
synonym: "calsarcin 1 binding" EXACT []
synonym: "calsarcin 2 binding" EXACT []
synonym: "calsarcin 3 binding" EXACT []
synonym: "calsarcin binding" EXACT []
synonym: "FATZ 1 binding" EXACT []
synonym: "FATZ 2 binding" EXACT []
synonym: "FATZ 3 binding" EXACT []
synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051377
name: mannose-ethanolamine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]
synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT []
synonym: "ethanolamine phosphate transferase activity" BROAD []
synonym: "EtN-P transferase activity" EXACT []
synonym: "phosphoethanolamine transferase activity" BROAD []
xref: Reactome:R-HSA-162798 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol"
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0051378
name: serotonin binding
namespace: molecular_function
def: "Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai]
synonym: "5-hydroxytryptamine binding" EXACT []
is_a: GO:0043169 ! cation binding
is_a: GO:0043176 ! amine binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051379
name: epinephrine binding
namespace: molecular_function
def: "Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai]
synonym: "adrenaline binding" EXACT []
is_a: GO:0042562 ! hormone binding
is_a: GO:0043169 ! cation binding
is_a: GO:1901338 ! catecholamine binding

[Term]
id: GO:0051380
name: norepinephrine binding
namespace: molecular_function
def: "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "noradrenaline binding" EXACT []
is_a: GO:0043169 ! cation binding
is_a: GO:1901338 ! catecholamine binding

[Term]
id: GO:0051381
name: histamine binding
namespace: molecular_function
def: "Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051382
name: kinetochore assembly
namespace: biological_process
alt_id: GO:0000069
alt_id: GO:0044768
def: "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]
synonym: "centromere and kinetochore complex maturation" NARROW []
synonym: "centromere/kinetochore complex maturation" NARROW []
synonym: "chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "kinetochore formation" RELATED []
synonym: "NMS complex assembly" NARROW []
is_a: GO:0051383 ! kinetochore organization
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0140694 ! membraneless organelle assembly
relationship: part_of GO:0034508 ! centromere complex assembly

[Term]
id: GO:0051383
name: kinetochore organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "kinetochore organisation" EXACT []
synonym: "kinetochore organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0051384
name: response to glucocorticoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123]
synonym: "response to glucocorticoid stimulus" EXACT [GOC:dos]
is_a: GO:0031960 ! response to corticosteroid

[Term]
id: GO:0051385
name: response to mineralocorticoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123]
synonym: "response to mineralocorticoid stimulus" EXACT [GOC:dos]
is_a: GO:0031960 ! response to corticosteroid

[Term]
id: GO:0051386
name: regulation of neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai]
synonym: "regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc]
synonym: "regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "regulation of NGF receptor signaling pathway" EXACT []
synonym: "regulation of NGF receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway

[Term]
id: GO:0051387
name: negative regulation of neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai]
synonym: "down regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of nerve growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc]
synonym: "negative regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "negative regulation of NGF receptor signaling pathway" EXACT []
synonym: "negative regulation of NGF receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
relationship: negatively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway

[Term]
id: GO:0051388
name: positive regulation of neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai]
synonym: "activation of nerve growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc]
synonym: "positive regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "positive regulation of NGF receptor signaling pathway" EXACT []
synonym: "positive regulation of NGF receptor signalling pathway" EXACT []
synonym: "stimulation of nerve growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of nerve growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway
relationship: positively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway

[Term]
id: GO:0051389
name: obsolete inactivation of MAPKK activity
namespace: biological_process
def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK)." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "inactivation of MAP kinase kinase activity" EXACT []
synonym: "termination of MAP kinase kinase activity" EXACT []
synonym: "termination of MAPKK activity" EXACT []
is_obsolete: true
consider: GO:0030291
consider: GO:0043409

[Term]
id: GO:0051390
name: obsolete inactivation of MAPKKK activity
namespace: biological_process
def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase kinase (MAPKKK)." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "inactivation of MAP kinase kinase kinase activity" EXACT []
synonym: "termination of MAP kinase kinase kinase activity" EXACT []
synonym: "termination of MAPKKK activity" EXACT []
is_obsolete: true
consider: GO:0030291
consider: GO:0043409

[Term]
id: GO:0051391
name: tRNA acetylation
namespace: biological_process
def: "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
is_a: GO:0006400 ! tRNA modification
is_a: GO:1990884 ! RNA acetylation

[Term]
id: GO:0051392
name: tRNA N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N4-acetylcytidine in tRNA + CoA + H+ + phosphate." [PMID:15037780, RHEA:53876]
synonym: "tRNA cytidine N-acetyltransferase activity" EXACT []
xref: RHEA:53876
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0051393
name: alpha-actinin binding
namespace: molecular_function
alt_id: GO:0051372
def: "Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165]
synonym: "alpha-actinin 1 binding" NARROW []
synonym: "alpha-actinin 4 binding" NARROW []
synonym: "nonmuscle alpha-actinin binding" NARROW []
is_a: GO:0042805 ! actinin binding

[Term]
id: GO:0051394
name: regulation of nerve growth factor receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "regulation of NGF receptor activity" EXACT []
is_a: GO:0010469 ! regulation of signaling receptor activity

[Term]
id: GO:0051395
name: obsolete negative regulation of nerve growth factor receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of nerve growth factor receptor activity" EXACT []
synonym: "down-regulation of nerve growth factor receptor activity" EXACT []
synonym: "downregulation of nerve growth factor receptor activity" EXACT []
synonym: "inhibition of nerve growth factor receptor activity" NARROW []
synonym: "negative regulation of NGF receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0051396
name: obsolete positive regulation of nerve growth factor receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of nerve growth factor receptor activity" NARROW []
synonym: "positive regulation of NGF receptor activity" EXACT []
synonym: "stimulation of nerve growth factor receptor activity" NARROW []
synonym: "up regulation of nerve growth factor receptor activity" EXACT []
synonym: "up-regulation of nerve growth factor receptor activity" EXACT []
synonym: "upregulation of nerve growth factor receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0051397
name: obsolete N-terminal basic amino acid aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "N-terminal basic amino acid aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051398
name: obsolete N-terminal lysine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
comment: This term was made obsolete because it represents a gene product.
synonym: "lysine aminopeptidase activity" BROAD []
synonym: "lysyl aminopeptidase activity" BROAD []
synonym: "N-terminal lysine aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051399
name: obsolete N-terminal arginine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
comment: This term was made obsolete because it represents a gene product.
synonym: "arginine aminopeptidase activity" BROAD []
synonym: "argininyl aminopeptidase activity" BROAD []
synonym: "N-terminal arginine aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051400
name: BH domain binding
namespace: molecular_function
def: "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]
subset: goslim_chembl
synonym: "Bcl-2 homology domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051401
name: CH domain binding
namespace: molecular_function
def: "Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021]
synonym: "calponin homology domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051402
name: neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis]
synonym: "apoptosis of neuronal cells" EXACT []
synonym: "apoptosis of neurons" EXACT []
synonym: "neuron apoptosis" NARROW []
synonym: "neuron programmed cell death by apoptosis" EXACT []
synonym: "neuronal cell apoptosis" EXACT []
synonym: "neuronal cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neuronal cells by apoptosis" EXACT []
synonym: "programmed cell death of neurons by apoptosis" EXACT []
synonym: "programmed cell death, neuronal cells" EXACT []
synonym: "programmed cell death, neurons" EXACT []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0051403
name: stress-activated MAPK cascade
namespace: biological_process
def: "A MAPK cascade that starts with the activation of a stress-activated MAP kinase cascade." [GOC:ai, PMID:15936270]
synonym: "MAPK11 cascade" NARROW [GOC:add]
synonym: "MAPK12 cascade" NARROW [GOC:add]
synonym: "MAPK13 cascade" NARROW [GOC:add]
synonym: "MAPK14 cascade" RELATED []
synonym: "SAPK cascade" BROAD [GOC:add]
synonym: "stress-activated MAPK signaling pathway" EXACT []
synonym: "stress-activated MAPK signalling pathway" EXACT []
synonym: "stress-activated MAPKKK cascade" EXACT []
synonym: "stress-activated MAPKKK signaling pathway" EXACT []
synonym: "stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0000165 ! MAPK cascade
is_a: GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0051404
name: obsolete clostripain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8]
synonym: "clostridiopeptidase B activity" EXACT []
synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8]
synonym: "clostripain activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0051405
name: obsolete microbial collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [GOC:curators]
comment: This term was made obsolete because it represents a gene product.
synonym: "Achromobacter iophagus collagenase" RELATED []
synonym: "aspergillopeptidase C" RELATED []
synonym: "azocollase activity" RELATED []
synonym: "clostridiopeptidase A activity" EXACT []
synonym: "clostridiopeptidase I" RELATED []
synonym: "clostridiopeptidase II" RELATED []
synonym: "Clostridium histolyticum collagenase activity" NARROW []
synonym: "Clostridium histolyticum proteinase A" RELATED []
synonym: "collagen peptidase activity" RELATED []
synonym: "collagen protease activity" RELATED []
synonym: "collagenase 1 activity" EXACT []
synonym: "collagenase A activity" EXACT []
synonym: "collagenase I activity" RELATED []
synonym: "collagenase MMP-1" RELATED []
synonym: "kollaza" RELATED []
synonym: "matrix metalloproteinase-1" RELATED []
synonym: "matrix metalloproteinase-18" RELATED []
synonym: "matrix metalloproteinase-8" RELATED []
synonym: "metallocollagenase activity" RELATED []
synonym: "metalloproteinase-1" RELATED []
synonym: "microbial collagenase activity" EXACT []
synonym: "nucleolysin" RELATED []
synonym: "soycollagestin" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0051407
name: glycerone phosphate:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai]
synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT []
synonym: "glycerone phosphate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:phosphate antiporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0051408
name: glyceraldehyde 3-phosphate:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai]
synonym: "glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0009670 ! triose-phosphate:phosphate antiporter activity

[Term]
id: GO:0051409
name: response to nitrosative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0051410
name: detoxification of nitrogen compound
namespace: biological_process
def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai]
synonym: "detoxification of nitrogenous compound" EXACT []
synonym: "nitric oxide (NO) detoxification" NARROW []
is_a: GO:0098754 ! detoxification
relationship: part_of GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0051411
name: obsolete ALP binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "actinin-associated LIM protein binding" EXACT []
synonym: "ALP binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051412
name: response to corticosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [PMID:15240347]
synonym: "response to corticosterone stimulus" EXACT [GOC:dos]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051413
name: response to cortisone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [ISBN:0721662544, PMID:11276391]
synonym: "response to cortisone stimulus" EXACT [GOC:dos]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051414
name: response to cortisol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544, PMID:11276391]
synonym: "response to cortisol stimulus" EXACT [GOC:dos]
synonym: "response to hydrocortisone stimulus" EXACT []
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051415
name: microtubule nucleation by interphase microtubule organizing center
namespace: biological_process
def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai]
synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT []
synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT []
synonym: "interphase microtubule nucleation by interphase microtubule organizing center" EXACT []
synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT []
synonym: "microtubule nucleation during interphase by IMTOC" EXACT []
synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT []
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center

[Term]
id: GO:0051416
name: obsolete myotilin binding
namespace: molecular_function
def: "OBSOLETE. Binding to myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "myotilin binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051417
name: microtubule nucleation by spindle pole body
namespace: biological_process
def: "The 'de novo' formation of a microtubule, mediated by the spindle pole body." [GOC:ai]
synonym: "microtubule nucleation by SPB" EXACT []
synonym: "SPB-mediated microtubule nucleation" EXACT []
synonym: "spindle pole body-mediated microtubule nucleation" EXACT []
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center

[Term]
id: GO:0051418
name: microtubule nucleation by microtubule organizing center
namespace: biological_process
def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai]
synonym: "microtubule nucleation by microtubule organising centre" EXACT []
synonym: "microtubule nucleation by MTOC" EXACT []
synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT []
synonym: "MTOC-mediated microtubule nucleation" EXACT []
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0051419
name: obsolete nebulin binding
namespace: molecular_function
def: "OBSOLETE. Binding to nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "nebulin binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051420
name: obsolete nebulette binding
namespace: molecular_function
def: "OBSOLETE. Binding to nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "nebulette binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051421
name: obsolete regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "endo-1,4-beta-xylanase regulator" RELATED []
synonym: "xylanase regulator" RELATED []
is_obsolete: true

[Term]
id: GO:0051422
name: obsolete negative regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the rate of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "down-regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "downregulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "endo-1,4-beta-xylanase inhibitor" RELATED []
synonym: "inhibition of endo-1,4-beta-xylanase activity" NARROW []
synonym: "xylanase inhibitor" RELATED []
is_obsolete: true

[Term]
id: GO:0051423
name: obsolete positive regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of endo-1,4-beta-xylanase activity" NARROW []
synonym: "endo-1,4-beta-xylanase activator" RELATED []
synonym: "stimulation of endo-1,4-beta-xylanase activity" NARROW []
synonym: "up regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "up-regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "upregulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "xylanase activator" RELATED []
is_obsolete: true

[Term]
id: GO:0051424
name: corticotropin-releasing hormone binding
namespace: molecular_function
alt_id: GO:0017047
def: "Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [PMID:7556876]
synonym: "corticoliberin binding" EXACT []
synonym: "corticotropin-releasing factor binding" EXACT []
synonym: "CRF binding" EXACT [GOC:bf]
synonym: "CRH binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051425
name: PTB domain binding
namespace: molecular_function
def: "Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain." [Pfam:PF02174, PMID:15924411]
synonym: "phosphotyrosine-interacting domain binding" EXACT []
synonym: "PID binding" BROAD []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051427
name: hormone receptor binding
namespace: molecular_function
def: "Binding to a receptor for a hormone." [GOC:ai]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0051428
name: peptide hormone receptor binding
namespace: molecular_function
def: "Binding to a receptor for a peptide hormone." [GOC:ai]
subset: goslim_chembl
synonym: "polypeptide hormone receptor binding" EXACT []
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0051429
name: corticotropin-releasing hormone receptor binding
namespace: molecular_function
alt_id: GO:0031742
def: "Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai]
synonym: "corticotropin releasing factor receptor binding" EXACT []
synonym: "corticotropin releasing factor receptor ligand" NARROW []
synonym: "corticotropin-releasing factor receptor binding" EXACT [GOC:bf]
synonym: "CRF receptor binding" EXACT [GOC:bf]
synonym: "CRH receptor binding" EXACT [GOC:bf]
synonym: "CRHR binding" EXACT [GOC:bf]
is_a: GO:0051428 ! peptide hormone receptor binding
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0051430
name: corticotropin-releasing hormone receptor 1 binding
namespace: molecular_function
alt_id: GO:0031743
def: "Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857]
synonym: "CRHR1 binding" EXACT []
synonym: "type 1 corticotropin releasing factor receptor binding" EXACT []
synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW []
synonym: "type 1 corticotropin-releasing factor receptor binding" EXACT [GOC:bf]
is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding

[Term]
id: GO:0051431
name: corticotropin-releasing hormone receptor 2 binding
namespace: molecular_function
alt_id: GO:0031744
def: "Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857]
synonym: "CRHR2 binding" EXACT []
synonym: "type 2 corticotropin releasing factor receptor binding" EXACT []
synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW []
synonym: "type 2 corticotropin-releasing factor receptor binding" EXACT [GOC:bf]
is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding

[Term]
id: GO:0051432
name: BH1 domain binding
namespace: molecular_function
def: "Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051433
name: BH2 domain binding
namespace: molecular_function
def: "Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051434
name: BH3 domain binding
namespace: molecular_function
def: "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]
subset: goslim_chembl
is_a: GO:0051400 ! BH domain binding
is_a: GO:0070513 ! death domain binding

[Term]
id: GO:0051435
name: BH4 domain binding
namespace: molecular_function
def: "Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051436
name: obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai, GOC:tb]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "APC inhibition during mitotic cell cycle" NARROW []
synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic anaphase promoting complex inhibition" NARROW []
synonym: "mitotic anaphase promoting complex inhibitor" NARROW []
synonym: "mitotic anaphase-promoting complex inhibition" NARROW []
synonym: "mitotic anaphase-promoting complex inhibitor" NARROW []
synonym: "mitotic APC inhibition" NARROW []
synonym: "mitotic APC inhibitor" NARROW []
synonym: "mitotic SCF complex inhibitor" NARROW []
synonym: "mitotic ubiquitin ligase inhibitor" NARROW []
synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb]
synonym: "negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0051437
name: obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition." [GOC:ai, GOC:tb]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic SCF complex activator" NARROW []
synonym: "mitotic ubiquitin ligase activator" NARROW []
synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb]
synonym: "positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
is_obsolete: true

[Term]
id: GO:0051438
name: regulation of ubiquitin-protein transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "anaphase-promoting complex regulator" NARROW []
synonym: "APC regulator" NARROW []
synonym: "regulation of ubiquitin transferase activity" EXACT [GOC:tb]
synonym: "SCF complex regulator" NARROW []
synonym: "ubiquitin transferase regulator" RELATED []
synonym: "ubiquitin-protein transferase regulator" RELATED []
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0051439
name: obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai]
comment: false
synonym: "mitotic anaphase-promoting complex regulator" NARROW []
synonym: "mitotic APC regulator" NARROW []
synonym: "mitotic SCF complex regulator" NARROW []
synonym: "mitotic ubiquitin ligase regulator" RELATED []
synonym: "mitotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb]
synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0051440
name: obsolete regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
synonym: "meiotic anaphase-promoting complex regulator" NARROW []
synonym: "meiotic APC regulator" NARROW []
synonym: "meiotic SCF complex regulator" NARROW []
synonym: "meiotic ubiquitin ligase regulator" RELATED []
synonym: "meiotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb]
synonym: "regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0051441
name: obsolete positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
namespace: biological_process
alt_id: GO:0051487
def: "OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:mah, GOC:tb, PMID:10871297]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
synonym: "activation of anaphase-promoting complex activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "activation of anaphase-promoting complex activity involved in meiotic cell cycle" NARROW []
synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" RELATED []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" RELATED []
synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" RELATED []
synonym: "anaphase promoting complex activation during meiotic cell cycle" RELATED []
synonym: "anaphase-promoting complex activation during meiotic cell cycle" RELATED []
synonym: "APC activation during meiotic cell cycle" RELATED []
synonym: "meiotic anaphase promoting complex activation" RELATED []
synonym: "meiotic anaphase promoting complex activator" NARROW []
synonym: "meiotic anaphase-promoting complex activator" NARROW []
synonym: "meiotic APC activation" EXACT []
synonym: "meiotic APC activator" NARROW []
synonym: "meiotic SCF complex activator" NARROW []
synonym: "meiotic ubiquitin ligase activator" NARROW []
synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb]
synonym: "positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
is_obsolete: true

[Term]
id: GO:0051442
name: obsolete negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "APC inhibition during meiotic cell cycle" NARROW []
synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "meiotic anaphase promoting complex inhibition" NARROW []
synonym: "meiotic anaphase promoting complex inhibitor" NARROW []
synonym: "meiotic anaphase-promoting complex inhibition" NARROW []
synonym: "meiotic anaphase-promoting complex inhibitor" NARROW []
synonym: "meiotic APC inhibition" NARROW []
synonym: "meiotic APC inhibitor" NARROW []
synonym: "meiotic SCF complex inhibitor" NARROW []
synonym: "meiotic ubiquitin ligase inhibitor" NARROW []
synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0051443
name: positive regulation of ubiquitin-protein transferase activity
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "activation of ubiquitin transferase activity" NARROW []
synonym: "anaphase promoting complex activator" NARROW []
synonym: "anaphase-promoting complex activator" NARROW []
synonym: "APC activation" NARROW []
synonym: "APC activator" NARROW []
synonym: "positive regulation of ubiquitin transferase activity" EXACT [GOC:tb]
synonym: "SCF complex activator" NARROW []
synonym: "stimulation of ubiquitin transferase activity" NARROW []
synonym: "ubiquitin transferase activator" NARROW []
synonym: "up regulation of ubiquitin ligase activity" RELATED []
synonym: "up-regulation of ubiquitin transferase activity" EXACT []
synonym: "upregulation of ubiquitin transferase activity" EXACT []
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity

[Term]
id: GO:0051444
name: negative regulation of ubiquitin-protein transferase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "anaphase promoting complex inhibition" NARROW []
synonym: "anaphase promoting complex inhibitor" NARROW []
synonym: "anaphase-promoting complex inhibition" NARROW []
synonym: "anaphase-promoting complex inhibitor" NARROW []
synonym: "APC inhibition" NARROW []
synonym: "APC inhibitor" NARROW []
synonym: "down regulation of ubiquitin transferase activity" EXACT []
synonym: "down-regulation of ubiquitin transferase activity" EXACT []
synonym: "downregulation of ubiquitin transferase activity" EXACT []
synonym: "inhibition of ubiquitin transferase activity" NARROW []
synonym: "negative regulation of ubiquitin transferase activity" EXACT [GOC:tb]
synonym: "SCF complex inhibitor" NARROW []
synonym: "ubiquitin transferase inhibitor" NARROW []
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity

[Term]
id: GO:0051445
name: regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "meiotic cell cycle modulation" EXACT []
synonym: "meiotic cell cycle regulation" EXACT []
synonym: "meiotic cell cycle regulator" RELATED []
synonym: "modulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051446
name: positive regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of progression through meiotic cell cycle" NARROW []
synonym: "positive regulation of meiotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through meiotic cell cycle" NARROW []
synonym: "up regulation of progression through meiotic cell cycle" EXACT []
synonym: "up-regulation of progression through meiotic cell cycle" EXACT []
synonym: "upregulation of progression through meiotic cell cycle" EXACT []
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051447
name: negative regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of progression through meiotic cell cycle" EXACT []
synonym: "down-regulation of progression through meiotic cell cycle" EXACT []
synonym: "downregulation of progression through meiotic cell cycle" EXACT []
synonym: "inhibition of progression through meiotic cell cycle" NARROW []
synonym: "negative regulation of meiotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051448
name: gonadotropin-releasing hormone binding
namespace: molecular_function
def: "Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:pr, PMID:1984190]
synonym: "GnRH binding" EXACT []
synonym: "gonadotrophin releasing hormone binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051449
name: thyrotropin-releasing hormone binding
namespace: molecular_function
def: "Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai]
synonym: "thyrotropin releasing hormone binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051450
name: myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0051451
name: myoblast migration
namespace: biological_process
def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration

[Term]
id: GO:0051452
name: intracellular pH reduction
namespace: biological_process
def: "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]
synonym: "cell pH reduction" EXACT []
synonym: "cellular acidification" EXACT []
synonym: "intracellular acidification" RELATED []
synonym: "reduction of cellular pH" EXACT []
synonym: "reduction of pH in cell" EXACT []
is_a: GO:0051453 ! regulation of intracellular pH

[Term]
id: GO:0051453
name: regulation of intracellular pH
namespace: biological_process
def: "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]
synonym: "cell pH regulation" EXACT []
synonym: "cellular pH regulation" EXACT []
synonym: "pH regulation in cell" EXACT []
synonym: "regulation of cell pH" EXACT []
is_a: GO:0030641 ! regulation of cellular pH
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0051454
name: intracellular pH elevation
namespace: biological_process
def: "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]
synonym: "cell pH elevation" EXACT []
synonym: "cellular alkalinization" EXACT []
synonym: "elevation of cellular pH" EXACT []
synonym: "intracellular alkalinization" EXACT []
synonym: "pH elevation in cell" EXACT []
is_a: GO:0051453 ! regulation of intracellular pH

[Term]
id: GO:0051455
name: spindle attachment to meiosis I kinetochore
namespace: biological_process
def: "The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb]
comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis.
synonym: "attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT []
synonym: "attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:dph, GOC:tb]
synonym: "monopolar attachment" RELATED []
synonym: "sister kinetochore mono-orientation" RELATED []
is_a: GO:0051316 ! attachment of meiotic spindle microtubules to kinetochore
relationship: part_of GO:0043060 ! meiotic metaphase I homologous chromosome alignment

[Term]
id: GO:0051456
name: attachment of meiotic spindle microtubules to meiosis II kinetochore
namespace: biological_process
def: "The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb]
synonym: "attachment of meiotic spindle microtubules to kinetochore in meiosis II" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore during meiosis II" RELATED [GOC:dph, GOC:tb]
synonym: "meiotic bipolar attachment" RELATED [GOC:vw]
is_a: GO:0051316 ! attachment of meiotic spindle microtubules to kinetochore
relationship: part_of GO:0043061 ! meiotic metaphase II chromosome alignment

[Term]
id: GO:0051457
name: maintenance of protein location in nucleus
namespace: biological_process
def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai]
synonym: "maintenance of nuclear protein localization" EXACT []
synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protein location in cell nucleus" EXACT []
synonym: "nuclear protein retention" NARROW []
synonym: "nuclear protein sequestering" NARROW []
synonym: "nuclear protein sequestration" NARROW []
synonym: "protein retention in nucleus" NARROW []
synonym: "protein sequestration in nucleus" NARROW []
synonym: "protein storage in nucleus" NARROW []
synonym: "protein-nuclear retention" NARROW []
synonym: "sequestration of protein in nucleus" NARROW []
synonym: "storage of protein in nucleus" NARROW []
is_a: GO:0072595 ! maintenance of protein localization in organelle
relationship: part_of GO:0034504 ! protein localization to nucleus

[Term]
id: GO:0051458
name: corticotropin secretion
namespace: biological_process
def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [GOC:cjm, PMID:11027914]
synonym: "ACTH secretion" EXACT []
synonym: "adrenocorticotropic hormone secretion" EXACT []
synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb]
synonym: "adrenotropic hormone secretion" EXACT []
synonym: "adrenotropin secretion" EXACT []
synonym: "corticotropic hormone secretion" EXACT []
is_a: GO:0030072 ! peptide hormone secretion
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0051459
name: regulation of corticotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai, GOC:dph]
synonym: "regulation of ACTH secretion" EXACT []
synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph]
synonym: "regulation of adrenocorticotropin secretion" EXACT []
synonym: "regulation of adrenotropin hormone secretion" EXACT []
synonym: "regulation of adrenotropin secretion" EXACT []
synonym: "regulation of corticotropic hormone secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0051458 ! corticotropin secretion

[Term]
id: GO:0051460
name: negative regulation of corticotropin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai]
synonym: "down regulation of adrenocorticotropin secretion" EXACT []
synonym: "down-regulation of adrenocorticotropin secretion" EXACT []
synonym: "downregulation of adrenocorticotropin secretion" EXACT []
synonym: "inhibition of adrenocorticotropin secretion" NARROW []
synonym: "negative regulation of ACTH secretion" EXACT []
synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenocorticotropin secretion" EXACT []
synonym: "negative regulation of adrenotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenotropin secretion" EXACT []
synonym: "negative regulation of corticotropic hormone secretion" EXACT []
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051459 ! regulation of corticotropin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0051458 ! corticotropin secretion

[Term]
id: GO:0051461
name: positive regulation of corticotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [GOC:ai]
synonym: "activation of adrenocorticotropin secretion" NARROW []
synonym: "positive regulation of ACTH secretion" EXACT []
synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of adrenotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenotropin secretion" EXACT []
synonym: "positive regulation of corticotropic hormone secretion" EXACT []
synonym: "stimulation of adrenocorticotropin secretion" NARROW []
synonym: "up regulation of adrenocorticotropin secretion" EXACT []
synonym: "up-regulation of adrenocorticotropin secretion" EXACT []
synonym: "upregulation of adrenocorticotropin secretion" EXACT []
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051459 ! regulation of corticotropin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0051458 ! corticotropin secretion

[Term]
id: GO:0051462
name: regulation of cortisol secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai]
is_a: GO:2000849 ! regulation of glucocorticoid secretion
relationship: regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051463
name: negative regulation of cortisol secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai]
synonym: "down regulation of cortisol secretion" EXACT []
synonym: "down-regulation of cortisol secretion" EXACT []
synonym: "downregulation of cortisol secretion" EXACT []
synonym: "inhibition of cortisol secretion" NARROW []
is_a: GO:0051462 ! regulation of cortisol secretion
is_a: GO:2000850 ! negative regulation of glucocorticoid secretion
relationship: negatively_regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051464
name: positive regulation of cortisol secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai]
synonym: "activation of cortisol secretion" NARROW []
synonym: "stimulation of cortisol secretion" NARROW []
synonym: "up regulation of cortisol secretion" EXACT []
synonym: "up-regulation of cortisol secretion" EXACT []
synonym: "upregulation of cortisol secretion" EXACT []
is_a: GO:0051462 ! regulation of cortisol secretion
is_a: GO:2000851 ! positive regulation of glucocorticoid secretion
relationship: positively_regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051465
name: negative regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai]
synonym: "down regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "down-regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "downregulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "inhibition of corticotropin-releasing hormone secretion" NARROW []
synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "negative regulation of CRF secretion" EXACT []
synonym: "negative regulation of CRH secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0051466
name: positive regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai]
synonym: "activation of corticotropin-releasing hormone secretion" NARROW []
synonym: "positive regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "positive regulation of CRF secretion" EXACT []
synonym: "positive regulation of CRH secretion" EXACT []
synonym: "stimulation of corticotropin-releasing hormone secretion" NARROW []
synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0051467
name: detection of steroid hormone stimulus
namespace: biological_process
def: "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0048545 ! response to steroid hormone

[Term]
id: GO:0051468
name: detection of glucocorticoid hormone stimulus
namespace: biological_process
def: "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0051467 ! detection of steroid hormone stimulus

[Term]
id: GO:0051469
name: vesicle fusion with vacuole
namespace: biological_process
alt_id: GO:0042146
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai]
synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED []
synonym: "heterotypic vacuole fusion, non-autophagic" RELATED []
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0097576 ! vacuole fusion

[Term]
id: GO:0051470
name: ectoine transmembrane transport
namespace: biological_process
def: "The directed movement of ectoine across a membrane by means of some agent such as a transporter or a pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai]
synonym: "ectoine transport" RELATED []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0051472
name: glucosylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai]
synonym: "glucosylglycerol metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019400 ! alditol metabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0051473
name: glucosylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai]
synonym: "glucosylglycerol anabolism" EXACT []
synonym: "glucosylglycerol biosynthesis" EXACT []
synonym: "glucosylglycerol formation" EXACT []
synonym: "glucosylglycerol synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0019401 ! alditol biosynthetic process
is_a: GO:0051472 ! glucosylglycerol metabolic process

[Term]
id: GO:0051474
name: glucosylglycerol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0051475
name: glucosylglycerol transmembrane transport
namespace: biological_process
def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, across a membrane." [GOC:ai]
synonym: "glucosylglycerol transport" BROAD []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0051476
name: phosphoenolpyruvate-dependent mannosylglycerate phosphotransferase system
namespace: biological_process
def: "A phosphoenolpyruvate-dependent sugar phosphotransferase transport specific for mammosylglycerate." [PMID:368051]
synonym: "mannosylglycerate transport" BROAD []
is_a: GO:0009401 ! phosphoenolpyruvate-dependent sugar phosphotransferase system
is_a: GO:1901656 ! glycoside transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0051477
name: mannosylglycerate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a mannosylglycerate from one side of a membrane to the other." [GOC:ai, PMID:15034926]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0051478
name: mannosylglycerate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai, PMID:11562374]
synonym: "mannosylglycerate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0051479
name: mannosylglycerate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai]
synonym: "mannosylglycerate anabolism" EXACT []
synonym: "mannosylglycerate biosynthesis" EXACT []
synonym: "mannosylglycerate formation" EXACT []
synonym: "mannosylglycerate synthesis" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0051478 ! mannosylglycerate metabolic process

[Term]
id: GO:0051480
name: regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]
synonym: "calcium ion homeostasis in cytoplasm" BROAD []
synonym: "calcium ion homeostasis in cytosol" EXACT []
synonym: "cytoplasmic calcium ion concentration regulation" BROAD []
synonym: "cytoplasmic calcium ion homeostasis" BROAD []
synonym: "cytosolic calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in cytoplasm" BROAD []
synonym: "regulation of calcium ion concentration in cytosol" EXACT []
synonym: "regulation of cytoplasmic calcium ion concentration" BROAD []
is_a: GO:0006874 ! intracellular calcium ion homeostasis

[Term]
id: GO:0051481
name: negative regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the cytosol." [GOC:ai]
synonym: "cytoplasmic calcium ion concentration reduction" BROAD []
synonym: "cytosolic calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in cytoplasm" BROAD []
synonym: "reduction of calcium ion concentration in cytosol" EXACT []
synonym: "reduction of cytoplasmic calcium ion concentration" BROAD []
synonym: "reduction of cytosolic calcium ion concentration" EXACT []
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0051482
name: obsolete positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol." [GOC:ai, GOC:signaling]
comment: This term was obsoleted because it represents a readout.
synonym: "elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" RELATED []
synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" RELATED []
synonym: "elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger" EXACT [GOC:signaling]
synonym: "elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway" EXACT []
synonym: "positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway" EXACT []
is_obsolete: true
replaced_by: GO:0007200

[Term]
id: GO:0051483
name: terpenoid biosynthetic process, mevalonate-independent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai]
synonym: "mevalonate-independent terpene biosynthesis" NARROW []
synonym: "mevalonate-independent terpene biosynthetic process" NARROW []
synonym: "mevalonate-independent terpenoid biosynthesis" EXACT []
synonym: "mevalonate-independent terpenoid biosynthetic process" EXACT []
synonym: "terpene biosynthesis, mevalonate-independent" NARROW []
synonym: "terpene biosynthetic process, mevalonate-independent" NARROW []
synonym: "terpenoid anabolism, mevalonate-independent" EXACT []
synonym: "terpenoid formation, mevalonate-independent" EXACT []
synonym: "terpenoid synthesis, mevalonate-independent" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0051484
name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai]
synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism" RELATED []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process" RELATED []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb]
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis" RELATED []
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation" RELATED []
synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis" RELATED []
is_a: GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
relationship: part_of GO:0051483 ! terpenoid biosynthetic process, mevalonate-independent

[Term]
id: GO:0051485
name: terpenoid biosynthetic process, mevalonate-dependent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai]
synonym: "terpene biosynthesis, mevalonate-dependent" NARROW []
synonym: "terpene biosynthetic process, mevalonate-dependent" NARROW []
synonym: "terpenoid anabolism, mevalonate-dependent" EXACT []
synonym: "terpenoid formation, mevalonate-dependent" EXACT []
synonym: "terpenoid synthesis, mevalonate-dependent" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0051486
name: isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai]
synonym: "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism" RELATED []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb]
synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis" RELATED []
synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation" RELATED []
synonym: "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis" RELATED []
is_a: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
relationship: part_of GO:0051485 ! terpenoid biosynthetic process, mevalonate-dependent

[Term]
id: GO:0051489
name: regulation of filopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
synonym: "regulation of filopodia biosynthesis" EXACT []
synonym: "regulation of filopodia formation" EXACT []
synonym: "regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051490
name: negative regulation of filopodium assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai]
synonym: "down regulation of filopodium formation" EXACT []
synonym: "down-regulation of filopodium formation" EXACT []
synonym: "downregulation of filopodium formation" EXACT []
synonym: "inhibition of filopodium formation" NARROW []
synonym: "negative regulation of filopodia biosynthesis" EXACT []
synonym: "negative regulation of filopodia formation" EXACT []
synonym: "negative regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051489 ! regulation of filopodium assembly
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
relationship: negatively_regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051491
name: positive regulation of filopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of filopodium formation" NARROW []
synonym: "positive regulation of filopodia biosynthesis" EXACT []
synonym: "positive regulation of filopodia formation" EXACT []
synonym: "positive regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of filopodium formation" NARROW []
synonym: "up regulation of filopodium formation" EXACT []
synonym: "up-regulation of filopodium formation" EXACT []
synonym: "upregulation of filopodium formation" EXACT []
is_a: GO:0051489 ! regulation of filopodium assembly
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
relationship: positively_regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051492
name: regulation of stress fiber assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "regulation of stress fibre biosynthesis" RELATED []
synonym: "regulation of stress fibre formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0110020 ! regulation of actomyosin structure organization
relationship: regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051493
name: regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051494
name: negative regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "down regulation of cytoskeleton organization" EXACT []
synonym: "down-regulation of cytoskeleton organization" EXACT []
synonym: "downregulation of cytoskeleton organization" EXACT []
synonym: "inhibition of cytoskeleton organization" NARROW []
synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: negatively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051495
name: positive regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "activation of cytoskeleton organization" NARROW []
synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cytoskeleton organization" NARROW []
synonym: "up regulation of cytoskeleton organization" EXACT []
synonym: "up-regulation of cytoskeleton organization" EXACT []
synonym: "upregulation of cytoskeleton organization" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: positively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051496
name: positive regulation of stress fiber assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "activation of stress fiber formation" NARROW []
synonym: "positive regulation of stress fibre biosynthesis" RELATED []
synonym: "positive regulation of stress fibre formation" RELATED []
synonym: "stimulation of stress fiber formation" NARROW []
synonym: "up regulation of stress fiber formation" RELATED []
synonym: "up-regulation of stress fiber formation" EXACT []
synonym: "upregulation of stress fiber formation" RELATED []
is_a: GO:0032233 ! positive regulation of actin filament bundle assembly
is_a: GO:0051492 ! regulation of stress fiber assembly
relationship: positively_regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051497
name: negative regulation of stress fiber assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "down regulation of stress fiber formation" RELATED []
synonym: "down-regulation of stress fiber formation" EXACT []
synonym: "downregulation of stress fiber formation" RELATED []
synonym: "inhibition of stress fiber formation" NARROW []
synonym: "negative regulation of stress fibre biosynthesis" RELATED []
synonym: "negative regulation of stress fibre formation" RELATED []
is_a: GO:0032232 ! negative regulation of actin filament bundle assembly
is_a: GO:0051492 ! regulation of stress fiber assembly
relationship: negatively_regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051498
name: syn-copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate." [MetaCyc:RXN-8528]
synonym: "diterpene cyclase activity" BROAD []
xref: EC:5.5.1.14
xref: MetaCyc:RXN-8528
xref: RHEA:25524
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0051499
name: D-aminoacyl-tRNA deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H+.  Removal of a D-amino acid from a charged tRNA." [PMID:14527667, RHEA:13953]
xref: EC:3.1.1.96
xref: MetaCyc:RXN-15041
xref: RHEA:13953
is_a: GO:0002161 ! aminoacyl-tRNA editing activity
is_a: GO:0160215 ! deacylase activity

[Term]
id: GO:0051500
name: D-tyrosyl-tRNA(Tyr) deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tyrosyl-tRNATyr + H2O = D-tyrosine + tRNATyr. Removal of a D-tyrosine from a charged tRNA(Tyr)." [PMID:14527667, RHEA:25347]
xref: RHEA:25347
is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity

[Term]
id: GO:0051501
name: diterpene phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units." [GOC:ai, ISBN:0721662544]
synonym: "diterpene phytoalexin metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0051502
name: diterpene phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses." [GOC:ai]
synonym: "diterpene phytoalexin anabolism" EXACT []
synonym: "diterpene phytoalexin biosynthesis" EXACT []
synonym: "diterpene phytoalexin formation" EXACT []
synonym: "diterpene phytoalexin synthesis" EXACT []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0051501 ! diterpene phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0051503
name: adenine nucleotide transport
namespace: biological_process
def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0051504
name: diterpene phytoalexin precursor biosynthetic process
namespace: biological_process
def: "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins." [MetaCyc:PWY-2981]
synonym: "diterpene phytoalexin precursor anabolism pathway" EXACT []
synonym: "diterpene phytoalexin precursor formation pathway" EXACT []
synonym: "diterpene phytoalexin precursor synthesis pathway" EXACT []
xref: MetaCyc:PWY-2981
is_a: GO:0046246 ! terpene biosynthetic process
relationship: part_of GO:0051502 ! diterpene phytoalexin biosynthetic process

[Term]
id: GO:0051506
name: obsolete ergosterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol." [GOC:ai]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0051507
name: obsolete beta-sitosterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0051508
name: obsolete stigmasterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol." [GOC:ai]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0051509
name: obsolete tomatidine UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine." [GOC:ai]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0051510
name: regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
synonym: "regulation of cell elongation" NARROW []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051511
name: negative regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
synonym: "down regulation of unidimensional cell growth" EXACT []
synonym: "down-regulation of unidimensional cell growth" EXACT []
synonym: "downregulation of unidimensional cell growth" EXACT []
synonym: "inhibition of unidimensional cell growth" NARROW []
synonym: "negative regulation of cell elongation" NARROW []
is_a: GO:0010771 ! negative regulation of cell morphogenesis
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: negatively_regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051512
name: positive regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
synonym: "activation of unidimensional cell growth" NARROW []
synonym: "positive regulation of cell elongation" NARROW []
synonym: "stimulation of unidimensional cell growth" NARROW []
synonym: "up regulation of unidimensional cell growth" EXACT []
synonym: "up-regulation of unidimensional cell growth" EXACT []
synonym: "upregulation of unidimensional cell growth" EXACT []
is_a: GO:0010770 ! positive regulation of cell morphogenesis
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: positively_regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051513
name: regulation of monopolar cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051514
name: negative regulation of monopolar cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
synonym: "down regulation of monopolar cell growth" EXACT []
synonym: "down-regulation of monopolar cell growth" EXACT []
synonym: "downregulation of monopolar cell growth" EXACT []
synonym: "inhibition of monopolar cell growth" NARROW []
is_a: GO:0051511 ! negative regulation of unidimensional cell growth
is_a: GO:0051513 ! regulation of monopolar cell growth
relationship: negatively_regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051515
name: positive regulation of monopolar cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
synonym: "stimulation of monopolar cell growth" NARROW []
synonym: "up regulation of monopolar cell growth" EXACT []
synonym: "up-regulation of monopolar cell growth" EXACT []
synonym: "upregulation of monopolar cell growth" EXACT []
is_a: GO:0051512 ! positive regulation of unidimensional cell growth
is_a: GO:0051513 ! regulation of monopolar cell growth
relationship: positively_regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051516
name: regulation of bipolar cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051517
name: negative regulation of bipolar cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "down regulation of bipolar cell growth" EXACT []
synonym: "down-regulation of bipolar cell growth" EXACT []
synonym: "downregulation of bipolar cell growth" EXACT []
synonym: "inhibition of bipolar cell growth" NARROW []
is_a: GO:0051511 ! negative regulation of unidimensional cell growth
is_a: GO:0051516 ! regulation of bipolar cell growth
relationship: negatively_regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051518
name: positive regulation of bipolar cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "stimulation of bipolar cell growth" NARROW []
synonym: "up regulation of bipolar cell growth" EXACT []
synonym: "up-regulation of bipolar cell growth" EXACT []
synonym: "upregulation of bipolar cell growth" EXACT []
is_a: GO:0051512 ! positive regulation of unidimensional cell growth
is_a: GO:0051516 ! regulation of bipolar cell growth
relationship: positively_regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051519
name: activation of bipolar cell growth
namespace: biological_process
def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
is_a: GO:0051518 ! positive regulation of bipolar cell growth

[Term]
id: GO:0051520
name: termination of bipolar cell growth
namespace: biological_process
def: "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
is_a: GO:0051517 ! negative regulation of bipolar cell growth

[Term]
id: GO:0051521
name: termination of monopolar cell growth
namespace: biological_process
def: "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051514 ! negative regulation of monopolar cell growth

[Term]
id: GO:0051522
name: activation of monopolar cell growth
namespace: biological_process
def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051515 ! positive regulation of monopolar cell growth

[Term]
id: GO:0051523
name: cell growth mode switching, monopolar to bipolar
namespace: biological_process
def: "The process in which a cell switches from monopolar cell growth to bipolar cell growth." [GOC:ai]
synonym: "NETO" NARROW [GOC:vw]
synonym: "new end take off" NARROW [GOC:vw]
is_a: GO:0061171 ! establishment of bipolar cell polarity
is_a: GO:0061389 ! regulation of direction of cell growth

[Term]
id: GO:0051524
name: cell growth mode switching, bipolar to monopolar
namespace: biological_process
def: "The process in which a cell switches from bipolar cell growth to monopolar cell growth." [GOC:ai]
is_a: GO:0061162 ! establishment of monopolar cell polarity
is_a: GO:0061389 ! regulation of direction of cell growth

[Term]
id: GO:0051525
name: NFAT protein binding
namespace: molecular_function
alt_id: GO:0051526
alt_id: GO:0051527
alt_id: GO:0051528
alt_id: GO:0051529
alt_id: GO:0051530
def: "Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679]
synonym: "NFAT binding" EXACT []
synonym: "NFAT1 protein binding" NARROW []
synonym: "NFAT2 protein binding" NARROW []
synonym: "NFAT3 protein binding" NARROW []
synonym: "NFAT4 protein binding" NARROW []
synonym: "NFAT5 protein binding" NARROW []
synonym: "NFATc binding" NARROW []
synonym: "NFATc1 binding" NARROW []
synonym: "NFATc2 binding" NARROW []
synonym: "NFATc3 binding" NARROW []
synonym: "NFATc4 binding" NARROW []
synonym: "NFATp binding" NARROW []
synonym: "NFATx binding" NARROW []
synonym: "non-calcium-regulated NFAT protein binding" NARROW []
synonym: "nuclear factor of activated T cell protein binding" EXACT []
is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding

[Term]
id: GO:0051536
name: iron-sulfur cluster binding
namespace: molecular_function
def: "Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
subset: goslim_metagenomics
synonym: "Fe/S binding" EXACT []
synonym: "iron sulfur cluster binding" EXACT []
synonym: "iron sulphur cluster binding" EXACT []
synonym: "iron-sulphur cluster binding" EXACT []
xref: Reactome:R-HSA-5690873 "ACO1 binds 4Fe-4S"
is_a: GO:0051540 ! metal cluster binding

[Term]
id: GO:0051537
name: 2 iron, 2 sulfur cluster binding
namespace: molecular_function
def: "Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
synonym: "2 Fe 2 S cluster binding" EXACT []
synonym: "2 iron, 2 sulphur cluster binding" EXACT []
synonym: "2Fe-2S cluster binding" EXACT []
synonym: "diiron disulfide cluster binding" EXACT []
synonym: "diiron disulphide cluster binding" EXACT []
synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT []
synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051538
name: 3 iron, 4 sulfur cluster binding
namespace: molecular_function
def: "Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
synonym: "3 Fe 4 S cluster binding" EXACT []
synonym: "3 iron, 4 sulphur cluster binding" EXACT []
synonym: "3Fe-4S cluster binding" EXACT []
synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT []
synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT []
synonym: "triiron tetrasulfide cluster binding" EXACT []
synonym: "triiron tetrasulphide cluster binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051539
name: 4 iron, 4 sulfur cluster binding
namespace: molecular_function
def: "Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
synonym: "4 Fe 4 S cluster binding" EXACT []
synonym: "4 iron, 4 sulphur cluster binding" EXACT []
synonym: "4Fe-4S cluster binding" EXACT []
synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT []
synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT []
synonym: "tetrairon tetrasulfide cluster binding" EXACT []
synonym: "tetrairon tetrasulphide cluster binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051540
name: metal cluster binding
namespace: molecular_function
def: "Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg]
subset: goslim_pir
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0051541
name: elastin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:curators]
synonym: "elastin metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0051542
name: elastin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries." [GOC:ai]
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0051541 ! elastin metabolic process

[Term]
id: GO:0051543
name: regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051544
name: positive regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
synonym: "activation of elastin biosynthetic process" NARROW []
synonym: "stimulation of elastin biosynthetic process" NARROW []
synonym: "up regulation of elastin biosynthetic process" EXACT []
synonym: "up-regulation of elastin biosynthetic process" EXACT []
synonym: "upregulation of elastin biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0051543 ! regulation of elastin biosynthetic process
relationship: positively_regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051545
name: negative regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
synonym: "down regulation of elastin biosynthetic process" EXACT []
synonym: "down-regulation of elastin biosynthetic process" EXACT []
synonym: "downregulation of elastin biosynthetic process" EXACT []
synonym: "inhibition of elastin biosynthetic process" NARROW []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0051543 ! regulation of elastin biosynthetic process
relationship: negatively_regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051546
name: keratinocyte migration
namespace: biological_process
def: "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544]
is_a: GO:0010631 ! epithelial cell migration

[Term]
id: GO:0051547
name: regulation of keratinocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai]
is_a: GO:0010632 ! regulation of epithelial cell migration
relationship: regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051548
name: negative regulation of keratinocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai]
synonym: "down regulation of keratinocyte migration" EXACT []
synonym: "down-regulation of keratinocyte migration" EXACT []
synonym: "downregulation of keratinocyte migration" EXACT []
synonym: "inhibition of keratinocyte migration" NARROW []
is_a: GO:0010633 ! negative regulation of epithelial cell migration
is_a: GO:0051547 ! regulation of keratinocyte migration
relationship: negatively_regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051549
name: positive regulation of keratinocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai]
synonym: "activation of keratinocyte migration" NARROW []
synonym: "stimulation of keratinocyte migration" NARROW []
synonym: "up regulation of keratinocyte migration" EXACT []
synonym: "up-regulation of keratinocyte migration" EXACT []
synonym: "upregulation of keratinocyte migration" EXACT []
is_a: GO:0010634 ! positive regulation of epithelial cell migration
is_a: GO:0051547 ! regulation of keratinocyte migration
relationship: positively_regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051550
name: aurone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides." [PMID:20035037]
synonym: "aurone metabolism" EXACT []
synonym: "benzalcoumaran-3-one metabolic process" EXACT []
synonym: "benzalcoumaran-3-one metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0051551
name: aurone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments." [GOC:ai, PMID:20035037]
synonym: "benzalcoumaran-3-one biosynthesis" EXACT []
synonym: "benzalcoumaran-3-one biosynthetic process" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051550 ! aurone metabolic process

[Term]
id: GO:0051552
name: flavone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [PMID:18567791]
synonym: "2-phenyl-4H-1-benzopyran-4-one metabolic process" NARROW []
synonym: "2-phenyl-4H-1-benzopyran-4-one metabolism" NARROW []
synonym: "2-phenylchromone metabolic process" NARROW []
synonym: "2-phenylchromone metabolism" NARROW []
synonym: "flavone metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0051553
name: flavone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [GOC:ai, PMID:18567791]
synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthesis" NARROW []
synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthetic process" NARROW []
synonym: "2-phenylchromone biosynthesis" NARROW []
synonym: "2-phenylchromone biosynthetic process" NARROW []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051552 ! flavone metabolic process

[Term]
id: GO:0051554
name: flavonol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [PMID:11402179]
synonym: "flavonol metabolism" EXACT []
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0051555
name: flavonol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [GOC:ai]
xref: MetaCyc:PWY-3101
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:0051554 ! flavonol metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0051556
name: leucoanthocyanidin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai]
synonym: "leucoanthocyanidin metabolism" EXACT []
xref: MetaCyc:PWY1F-823
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0051557
name: leucoanthocyanidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai]
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0051556 ! leucoanthocyanidin metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0051558
name: phlobaphene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179]
synonym: "phlobaphene metabolism" EXACT []
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0051559
name: phlobaphene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051558 ! phlobaphene metabolic process

[Term]
id: GO:0051560
name: mitochondrial calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]
synonym: "calcium ion homeostasis in mitochondria" EXACT []
synonym: "calcium ion homeostasis in mitochondrion" EXACT []
synonym: "mitochondrial calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in mitochondria" EXACT []
synonym: "regulation of calcium ion concentration in mitochondrion" EXACT []
synonym: "regulation of mitochondrial calcium ion concentration" EXACT []
is_a: GO:0006874 ! intracellular calcium ion homeostasis

[Term]
id: GO:0051561
name: positive regulation of mitochondrial calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in mitochondria." [GOC:ai]
synonym: "elevation of calcium ion concentration in mitochondria" EXACT []
synonym: "elevation of calcium ion concentration in mitochondrion" EXACT []
synonym: "elevation of mitochondrial calcium ion concentration" EXACT []
synonym: "mitochondrial calcium ion concentration elevation" EXACT []
is_a: GO:0051560 ! mitochondrial calcium ion homeostasis

[Term]
id: GO:0051562
name: negative regulation of mitochondrial calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in mitochondria." [GOC:ai]
synonym: "mitochondrial calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in mitochondria" EXACT []
synonym: "reduction of calcium ion concentration in mitochondrion" EXACT []
synonym: "reduction of mitochondrial calcium ion concentration" EXACT []
is_a: GO:0051560 ! mitochondrial calcium ion homeostasis

[Term]
id: GO:0051563
name: smooth endoplasmic reticulum calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai, GOC:mah]
synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT []
synonym: "calcium ion homeostasis in smooth ER" EXACT []
synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "regulation of calcium ion concentration in smooth ER" EXACT []
synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "regulation of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT []
synonym: "smooth ER calcium ion concentration regulation" EXACT []
synonym: "smooth ER calcium ion homeostasis" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051564
name: positive regulation of smooth endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai]
synonym: "elevation of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "elevation of smooth endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "elevation of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration elevation" EXACT []
is_a: GO:0032470 ! positive regulation of endoplasmic reticulum calcium ion concentration
is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051565
name: negative regulation of smooth endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai]
synonym: "reduction of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "reduction of calcium ion concentration in smooth ER" EXACT []
synonym: "reduction of smooth endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "reduction of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration reduction" EXACT []
synonym: "smooth ER calcium ion concentration reduction" EXACT []
is_a: GO:0032471 ! negative regulation of endoplasmic reticulum calcium ion concentration
is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051566
name: anthocyanidin 3-glucoside rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800]
synonym: "3RT activity" BROAD []
synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT []
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0051567
name: obsolete histone H3-K9 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone." [GOC:ai, GOC:pr]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K9 methylation" EXACT []
synonym: "histone H3K9me" EXACT []
synonym: "histone lysine H3 K9 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0051568
name: obsolete histone H3-K4 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K4 methylation" EXACT []
synonym: "histone H3K4me" EXACT []
synonym: "histone lysine H3 K4 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0051569
name: obsolete regulation of histone H3-K4 methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051570
name: obsolete regulation of histone H3-K9 methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0051571
name: obsolete positive regulation of histone H3-K4 methylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3-K4 methylation" NARROW []
synonym: "stimulation of histone H3-K4 methylation" NARROW []
synonym: "up regulation of histone H3-K4 methylation" EXACT []
synonym: "up-regulation of histone H3-K4 methylation" EXACT []
synonym: "upregulation of histone H3-K4 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0051572
name: obsolete negative regulation of histone H3-K4 methylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3-K4 methylation" EXACT []
synonym: "down-regulation of histone H3-K4 methylation" EXACT []
synonym: "downregulation of histone H3-K4 methylation" EXACT []
synonym: "inhibition of histone H3-K4 methylation" NARROW []
is_obsolete: true

[Term]
id: GO:0051573
name: obsolete negative regulation of histone H3-K9 methylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3-K9 methylation" EXACT []
synonym: "down-regulation of histone H3-K9 methylation" EXACT []
synonym: "downregulation of histone H3-K9 methylation" EXACT []
synonym: "inhibition of histone H3-K9 methylation" NARROW []
is_obsolete: true

[Term]
id: GO:0051574
name: obsolete positive regulation of histone H3-K9 methylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3-K9 methylation" NARROW []
synonym: "stimulation of histone H3-K9 methylation" NARROW []
synonym: "up regulation of histone H3-K9 methylation" EXACT []
synonym: "up-regulation of histone H3-K9 methylation" EXACT []
synonym: "upregulation of histone H3-K9 methylation" EXACT []
is_obsolete: true

[Term]
id: GO:0051575
name: 5'-deoxyribose-5-phosphate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+." [PMID:11251121, PMID:16120966, PMID:9614142, RHEA:76255]
synonym: "5'-deoxyribose phosphate activity" EXACT []
synonym: "dRP lyase activity" BROAD []
synonym: "dRPase activity" BROAD []
xref: RHEA:76255
is_a: GO:0016835 ! carbon-oxygen lyase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0051580
name: regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
subset: goslim_synapse
synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurotransmitter reuptake" EXACT []
is_a: GO:0051588 ! regulation of neurotransmitter transport
relationship: regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051581
name: negative regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of neurotransmitter uptake" EXACT []
synonym: "down-regulation of neurotransmitter uptake" EXACT []
synonym: "downregulation of neurotransmitter uptake" EXACT []
synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051582
name: positive regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "activation of neurotransmitter uptake" NARROW []
synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of neurotransmitter uptake" NARROW []
synonym: "up regulation of neurotransmitter uptake" EXACT []
synonym: "up-regulation of neurotransmitter uptake" EXACT []
synonym: "upregulation of neurotransmitter uptake" EXACT []
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
relationship: positively_regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051583
name: dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
synonym: "dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine reuptake involved in synaptic transmission" EXACT []
is_a: GO:0051934 ! catecholamine uptake involved in synaptic transmission
is_a: GO:0090494 ! dopamine uptake
relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0051584
name: regulation of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell." [GOC:ai]
synonym: "regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
relationship: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission

[Term]
id: GO:0051585
name: negative regulation of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell." [GOC:ai]
synonym: "down regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "down-regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "downregulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "negative regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission
relationship: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission

[Term]
id: GO:0051586
name: positive regulation of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai]
synonym: "activation of dopamine uptake involved in synaptic transmission" NARROW []
synonym: "positive regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of dopamine uptake involved in synaptic transmission" NARROW []
synonym: "up regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "up-regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "upregulation of dopamine uptake involved in synaptic transmission" EXACT []
is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission
relationship: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission

[Term]
id: GO:0051587
name: inhibition of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of dopamine into a cell." [GOC:ai]
synonym: "inhibition of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051585 ! negative regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051609 ! inhibition of neurotransmitter uptake

[Term]
id: GO:0051588
name: regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051589
name: negative regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of neurotransmitter transport" EXACT []
synonym: "down-regulation of neurotransmitter transport" EXACT []
synonym: "downregulation of neurotransmitter transport" EXACT []
synonym: "inhibition of neurotransmitter transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
relationship: negatively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051590
name: positive regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of neurotransmitter transport" NARROW []
synonym: "stimulation of neurotransmitter transport" NARROW []
synonym: "up regulation of neurotransmitter transport" EXACT []
synonym: "up-regulation of neurotransmitter transport" EXACT []
synonym: "upregulation of neurotransmitter transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
relationship: positively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051591
name: response to cAMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai]
synonym: "response to 3',5' cAMP" EXACT []
synonym: "response to 3',5'-cAMP" EXACT []
synonym: "response to adenosine 3',5'-cyclophosphate" EXACT []
synonym: "response to cyclic AMP" EXACT []
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0051592
name: response to calcium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]
synonym: "response to Ca2+ ion" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0051593
name: response to folic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai]
synonym: "cellular response to folate" EXACT [GOC:mah]
synonym: "cellular response to vitamin B9" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0051594
name: detection of glucose
namespace: biological_process
def: "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "glucose detection" EXACT []
synonym: "glucose perception" RELATED []
synonym: "glucose sensing" RELATED []
is_a: GO:0009732 ! detection of hexose stimulus
is_a: GO:0009749 ! response to glucose

[Term]
id: GO:0051595
name: response to methylglyoxal
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:ai]
synonym: "response to pyruvaldehyde" EXACT []
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051596
name: methylglyoxal catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai]
synonym: "methylglyoxal breakdown" EXACT []
synonym: "methylglyoxal catabolism" EXACT []
synonym: "methylglyoxal degradation" EXACT []
xref: MetaCyc:Methylglyoxal-Detoxification
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0051597
name: response to methylmercury
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:ai]
synonym: "response to CH3-Hg+" EXACT []
synonym: "response to MeHg+" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0051598
name: meiotic recombination checkpoint signaling
namespace: biological_process
alt_id: GO:0072462
def: "A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes." [PMID:14718568]
synonym: "meiotic recombination checkpoint" EXACT []
synonym: "pachytene checkpoint" EXACT []
synonym: "signal transduction involved in meiotic recombination checkpoint" EXACT []
is_a: GO:0033313 ! meiotic cell cycle checkpoint signaling
is_a: GO:0045835 ! negative regulation of meiotic nuclear division

[Term]
id: GO:0051599
name: response to hydrostatic pressure
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [Wikipedia:Hydrostatic_pressure]
synonym: "response to biomechanical stress" BROAD []
synonym: "response to static fluid pressure" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0051600
name: regulation of endocytosis by exocyst localization
namespace: biological_process
def: "Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai, GOC:dph, GOC:tb]
synonym: "regulation of endocytosis by exocyst localisation" EXACT [GOC:mah]
synonym: "regulation of site selection of endocytosis" RELATED []
synonym: "relocation of endocytosis" RELATED []
synonym: "spatial regulation of endocytosis" RELATED []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051601 ! exocyst localization

[Term]
id: GO:0051601
name: exocyst localization
namespace: biological_process
def: "Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai]
synonym: "establishment and maintenance of exocyst localization" EXACT []
synonym: "exocyst localisation" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0051602
name: response to electrical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai]
synonym: "response to electricity" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0051603
name: proteolysis involved in protein catabolic process
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "peptidolysis during cellular protein catabolic process" RELATED []
synonym: "peptidolysis during cellular protein catabolism" RELATED []
synonym: "peptidolysis involved in cellular protein catabolic process" EXACT []
synonym: "peptidolysis involved in cellular protein catabolism" EXACT []
synonym: "proteolysis during cellular protein catabolic process" RELATED []
synonym: "proteolysis during cellular protein catabolism" RELATED []
synonym: "proteolysis involved in cellular protein catabolic process" EXACT []
is_a: GO:0006508 ! proteolysis
relationship: part_of GO:0030163 ! protein catabolic process

[Term]
id: GO:0051604
name: protein maturation
namespace: biological_process
def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
is_a: GO:0019538 ! protein metabolic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0051606
name: detection of stimulus
namespace: biological_process
def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]
subset: goslim_pir
synonym: "perception of stimulus" RELATED []
synonym: "stimulus detection" EXACT []
synonym: "stimulus sensing" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051607
name: defense response to virus
namespace: biological_process
def: "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
synonym: "antiviral response" EXACT []
synonym: "defence response to virus" EXACT []
synonym: "defense response to viruses" EXACT []
is_a: GO:0009615 ! response to virus
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0051608
name: histamine transport
namespace: biological_process
def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0051609
name: inhibition of neurotransmitter uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell." [GOC:ai]
synonym: "inhibition of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake

[Term]
id: GO:0051610
name: serotonin uptake
namespace: biological_process
def: "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
synonym: "5-HT uptake" EXACT []
synonym: "5-hydroxytryptamine uptake" EXACT []
synonym: "5HT uptake" EXACT []
synonym: "serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0098810 ! neurotransmitter reuptake

[Term]
id: GO:0051611
name: regulation of serotonin uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell." [GOC:ai]
synonym: "regulation of 5-HT uptake" EXACT []
synonym: "regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "regulation of 5HT uptake" EXACT []
synonym: "regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
relationship: regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051612
name: negative regulation of serotonin uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "down regulation of serotonin uptake" EXACT []
synonym: "down-regulation of serotonin uptake" EXACT []
synonym: "downregulation of serotonin uptake" EXACT []
synonym: "negative regulation of 5-HT uptake" EXACT []
synonym: "negative regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "negative regulation of 5HT uptake" EXACT []
synonym: "negative regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051611 ! regulation of serotonin uptake
relationship: negatively_regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051613
name: positive regulation of serotonin uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "activation of serotonin uptake" NARROW []
synonym: "positive regulation of 5-HT uptake" EXACT []
synonym: "positive regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "positive regulation of 5HT uptake" EXACT []
synonym: "positive regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of serotonin uptake" NARROW []
synonym: "up regulation of serotonin uptake" EXACT []
synonym: "up-regulation of serotonin uptake" EXACT []
synonym: "upregulation of serotonin uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051611 ! regulation of serotonin uptake
relationship: positively_regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051614
name: inhibition of serotonin uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "inhibition of 5-HT uptake" EXACT []
synonym: "inhibition of 5-hydroxytryptamine uptake" EXACT []
synonym: "inhibition of 5HT uptake" EXACT []
synonym: "inhibition of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051612 ! negative regulation of serotonin uptake

[Term]
id: GO:0051615
name: histamine uptake
namespace: biological_process
def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
synonym: "histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0051616
name: regulation of histamine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai]
synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
relationship: regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051617
name: negative regulation of histamine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai]
synonym: "down regulation of histamine uptake" EXACT []
synonym: "down-regulation of histamine uptake" EXACT []
synonym: "downregulation of histamine uptake" EXACT []
synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051616 ! regulation of histamine uptake
relationship: negatively_regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051618
name: positive regulation of histamine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai]
synonym: "activation of histamine uptake" NARROW []
synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of histamine uptake" NARROW []
synonym: "up regulation of histamine uptake" EXACT []
synonym: "up-regulation of histamine uptake" EXACT []
synonym: "upregulation of histamine uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051616 ! regulation of histamine uptake
relationship: positively_regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051619
name: inhibition of histamine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of histamine into a cell." [GOC:ai]
synonym: "inhibition of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051617 ! negative regulation of histamine uptake

[Term]
id: GO:0051620
name: norepinephrine uptake
namespace: biological_process
def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "levarterenol reuptake" EXACT []
synonym: "levarterenol uptake" EXACT []
synonym: "noradrenaline reuptake" EXACT []
synonym: "noradrenaline uptake" EXACT []
synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "norepinephrine reuptake" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0090493 ! catecholamine uptake

[Term]
id: GO:0051621
name: regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai]
synonym: "regulation of levarterenol uptake" EXACT []
synonym: "regulation of noradrenaline uptake" EXACT []
synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051622
name: negative regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "down regulation of norepinephrine uptake" EXACT []
synonym: "down-regulation of norepinephrine uptake" EXACT []
synonym: "downregulation of norepinephrine uptake" EXACT []
synonym: "negative regulation of levarterenol uptake" EXACT []
synonym: "negative regulation of noradrenaline uptake" EXACT []
synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051621 ! regulation of norepinephrine uptake
relationship: negatively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051623
name: positive regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "activation of norepinephrine uptake" NARROW []
synonym: "positive regulation of levarterenol uptake" EXACT []
synonym: "positive regulation of noradrenaline uptake" EXACT []
synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of norepinephrine uptake" NARROW []
synonym: "up regulation of norepinephrine uptake" EXACT []
synonym: "up-regulation of norepinephrine uptake" EXACT []
synonym: "upregulation of norepinephrine uptake" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051621 ! regulation of norepinephrine uptake
relationship: positively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051624
name: inhibition of norepinephrine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "inhibition of levarterenol uptake" EXACT []
synonym: "inhibition of noradrenaline uptake" EXACT []
synonym: "inhibition of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051622 ! negative regulation of norepinephrine uptake

[Term]
id: GO:0051625
name: epinephrine uptake
namespace: biological_process
def: "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai]
synonym: "adrenaline reuptake" EXACT []
synonym: "adrenaline uptake" EXACT []
synonym: "epinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "epinephrine reuptake" EXACT []
is_a: GO:0006810 ! transport

[Term]
id: GO:0051626
name: regulation of epinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell." [GOC:ai]
synonym: "regulation of adrenaline uptake" EXACT []
synonym: "regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051627
name: negative regulation of epinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "down regulation of epinephrine uptake" EXACT []
synonym: "down-regulation of epinephrine uptake" EXACT []
synonym: "downregulation of epinephrine uptake" EXACT []
synonym: "negative regulation of adrenaline uptake" EXACT []
synonym: "negative regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051626 ! regulation of epinephrine uptake
relationship: negatively_regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051628
name: positive regulation of epinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "activation of epinephrine uptake" NARROW []
synonym: "positive regulation of adrenaline uptake" EXACT []
synonym: "positive regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of epinephrine uptake" NARROW []
synonym: "up regulation of epinephrine uptake" EXACT []
synonym: "up-regulation of epinephrine uptake" EXACT []
synonym: "upregulation of epinephrine uptake" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051626 ! regulation of epinephrine uptake
relationship: positively_regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051629
name: inhibition of epinephrine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "inhibition of adrenaline uptake" EXACT []
synonym: "inhibition of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051627 ! negative regulation of epinephrine uptake

[Term]
id: GO:0051630
name: acetylcholine uptake
namespace: biological_process
def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai]
synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015870 ! acetylcholine transport

[Term]
id: GO:0051631
name: regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai]
synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051632
name: negative regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "down regulation of acetylcholine uptake" EXACT []
synonym: "down-regulation of acetylcholine uptake" EXACT []
synonym: "downregulation of acetylcholine uptake" EXACT []
synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051633
name: positive regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "activation of acetylcholine uptake" NARROW []
synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of acetylcholine uptake" NARROW []
synonym: "up regulation of acetylcholine uptake" EXACT []
synonym: "up-regulation of acetylcholine uptake" EXACT []
synonym: "upregulation of acetylcholine uptake" EXACT []
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051634
name: inhibition of acetylcholine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "inhibition of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051632 ! negative regulation of acetylcholine uptake

[Term]
id: GO:0051635
name: obsolete bacterial cell surface binding
namespace: molecular_function
alt_id: GO:0008367
def: "OBSOLETE. Binding to a component on the surface of a bacterial cell." [GOC:ai]
comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term.
synonym: "bacterial binding" EXACT []
synonym: "bacterial cell surface binding" EXACT []
synonym: "bacterium binding" EXACT []
synonym: "bacterium cell surface binding" EXACT []
synonym: "binding to bacterium" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0005102
consider: GO:0042742

[Term]
id: GO:0051636
name: obsolete Gram-negative bacterial cell surface binding
namespace: molecular_function
alt_id: GO:0008368
def: "OBSOLETE. Binding to a component on the surface of a Gram-negative bacterial cell." [GOC:ai]
comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion.
synonym: "binding to Gram-negative bacterium" EXACT []
synonym: "Gram-negative bacterial binding" EXACT []
synonym: "Gram-negative bacterial cell surface binding" EXACT []
synonym: "Gram-negative bacterium binding" EXACT []
synonym: "Gram-negative bacterium cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0050829

[Term]
id: GO:0051637
name: obsolete Gram-positive bacterial cell surface binding
namespace: molecular_function
alt_id: GO:0051076
def: "OBSOLETE. Binding to a component on the surface of a Gram-positive bacterium." [GOC:ai]
comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion.
synonym: "binding to Gram-positive bacterium" EXACT []
synonym: "Gram-positive bacterial binding" EXACT []
synonym: "Gram-positive bacterial cell surface binding" EXACT []
synonym: "Gram-positive bacterium binding" EXACT []
synonym: "Gram-positive bacterium cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0050830

[Term]
id: GO:0051638
name: barbed-end actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "barbed end actin filament uncapping" EXACT []
synonym: "barbed end F-actin uncapping" EXACT []
synonym: "barbed-end F-actin uncapping" EXACT []
synonym: "plus end actin filament uncapping" EXACT []
synonym: "plus end F-actin uncapping" EXACT []
synonym: "plus-end actin filament uncapping" EXACT []
synonym: "plus-end F-actin uncapping" EXACT []
is_a: GO:0051695 ! actin filament uncapping

[Term]
id: GO:0051639
name: actin filament network formation
namespace: biological_process
def: "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]
synonym: "actin gel biosynthesis" EXACT []
synonym: "actin gel formation" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0051640
name: organelle localization
namespace: biological_process
def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: goslim_pir
synonym: "establishment and maintenance of organelle localization" EXACT []
synonym: "organelle localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0051641
name: cellular localization
namespace: biological_process
alt_id: GO:1902580
def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of cellular localization" EXACT []
synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT []
synonym: "intracellular localization" NARROW []
synonym: "localization within cell" NARROW []
synonym: "single organism cellular localization" EXACT [GOC:TermGenie]
synonym: "single-organism cellular localization" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization

[Term]
id: GO:0051642
name: centrosome localization
namespace: biological_process
def: "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "centrosome localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of centrosome localization" EXACT []
is_a: GO:0061842 ! microtubule organizing center localization

[Term]
id: GO:0051643
name: endoplasmic reticulum localization
namespace: biological_process
def: "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "endoplasmic reticulum localisation" EXACT [GOC:mah]
synonym: "ER localization" EXACT [GOC:dph]
synonym: "establishment and maintenance of ER localization" EXACT []
is_a: GO:0051640 ! organelle localization
relationship: part_of GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0051644
name: plastid localization
namespace: biological_process
def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of plastid localization" EXACT []
synonym: "plastid localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051645
name: Golgi localization
namespace: biological_process
def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of Golgi localization" EXACT []
synonym: "Golgi apparatus localization" EXACT []
synonym: "Golgi body localization" EXACT []
synonym: "Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051646
name: mitochondrion localization
namespace: biological_process
def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of mitochondria localization" EXACT []
synonym: "establishment and maintenance of mitochondrion localization" EXACT []
synonym: "localization of mitochondria" EXACT []
synonym: "localization of mitochondrion" EXACT []
synonym: "mitochondria localization" EXACT []
synonym: "mitochondrial localization" EXACT []
synonym: "mitochondrion localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051647
name: nucleus localization
namespace: biological_process
def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "cell nucleus localization" EXACT []
synonym: "establishment and maintenance of nucleus localization" EXACT []
synonym: "localization of nucleus" EXACT []
synonym: "nucleus localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051648
name: vesicle localization
namespace: biological_process
def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cytoplasmic vesicle localization" EXACT []
synonym: "establishment and maintenance of vesicle localization" EXACT []
synonym: "vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051649
name: establishment of localization in cell
namespace: biological_process
def: "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of intracellular localization" NARROW []
synonym: "establishment of localisation in cell" EXACT [GOC:mah]
synonym: "establishment of localization within cell" NARROW []
synonym: "positioning within cell" NARROW []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0051641 ! cellular localization

[Term]
id: GO:0051650
name: establishment of vesicle localization
namespace: biological_process
def: "The directed movement of a vesicle to a specific location." [GOC:ai]
synonym: "establishment of vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051651
name: maintenance of location in cell
namespace: biological_process
def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]
synonym: "cellular retention" NARROW []
synonym: "cellular sequestering" NARROW []
synonym: "cellular storage" NARROW []
synonym: "intracellular retention" NARROW []
synonym: "intracellular sequestering" NARROW []
synonym: "intracellular storage" NARROW []
synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of intracellular localization" NARROW []
synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of localization within cell" NARROW []
synonym: "retention within cell" NARROW []
synonym: "sequestering within cell" NARROW []
synonym: "storage within cell" NARROW []
is_a: GO:0009987 ! cellular process
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0051641 ! cellular localization

[Term]
id: GO:0051652
name: maintenance of chromosome location
namespace: biological_process
def: "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0050000 ! chromosome localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051653
name: spindle localization
namespace: biological_process
def: "Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of spindle localization" EXACT []
synonym: "spindle localisation" EXACT [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051654
name: establishment of mitochondrion localization
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location." [GOC:ai]
synonym: "establishment of mitochondria localization" EXACT []
synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah]
synonym: "mitochondria positioning" EXACT []
synonym: "mitochondrial migration" EXACT []
synonym: "mitochondrion positioning" EXACT []
is_a: GO:0051646 ! mitochondrion localization
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051655
name: maintenance of vesicle location
namespace: biological_process
def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051648 ! vesicle localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051656
name: establishment of organelle localization
namespace: biological_process
def: "The directed movement of an organelle to a specific location." [GOC:ai]
synonym: "establishment of organelle localisation" EXACT [GOC:mah]
is_a: GO:0051234 ! establishment of localization
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051657
name: maintenance of organelle location
namespace: biological_process
def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0051640 ! organelle localization

[Term]
id: GO:0051658
name: maintenance of nucleus location
namespace: biological_process
def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of cell nucleus location" EXACT []
synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051647 ! nucleus localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051659
name: maintenance of mitochondrion location
namespace: biological_process
def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of mitochondria localization" EXACT []
synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051646 ! mitochondrion localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051660
name: establishment of centrosome localization
namespace: biological_process
def: "The directed movement of the centrosome to a specific location." [GOC:ai]
synonym: "centrosome positioning" EXACT []
synonym: "establishment of centrosome localisation" EXACT [GOC:mah]
is_a: GO:0051642 ! centrosome localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051661
name: maintenance of centrosome location
namespace: biological_process
def: "Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of centrosome localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051642 ! centrosome localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051663
name: oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0051662
def: "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb]
synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination" EXACT []
synonym: "oocyte axis determination, oocyte nucleus localization" EXACT []
synonym: "oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0051647 ! nucleus localization
relationship: part_of GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0051664
name: nuclear pore localization
namespace: biological_process
alt_id: GO:0031081
def: "Any process in which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of nuclear pore localization" EXACT []
synonym: "nuclear pore distribution" RELATED []
synonym: "nuclear pore localisation" EXACT [GOC:mah]
synonym: "positioning of nuclear pores" RELATED []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0051665
name: membrane raft localization
namespace: biological_process
def: "Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:ai, PMID:16645198]
synonym: "establishment and maintenance of membrane raft localization" EXACT []
synonym: "lipid raft localization" EXACT []
synonym: "membrane raft localisation" EXACT [GOC:mah]
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0051666
name: actin cortical patch localization
namespace: biological_process
def: "Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah]
synonym: "actin cortical patch localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of actin cortical patch localization" EXACT []
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051667
name: establishment of plastid localization
namespace: biological_process
def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai]
synonym: "establishment of plastid localisation" EXACT [GOC:mah]
is_a: GO:0051644 ! plastid localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051668
name: localization within membrane
namespace: biological_process
def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai]
synonym: "establishment and maintenance of localization in membrane" EXACT []
synonym: "establishment and maintenance of position in membrane" EXACT []
synonym: "localisation within membrane" EXACT [GOC:mah]
synonym: "localization to membrane" EXACT []
synonym: "positioning within membrane" NARROW []
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051669
name: fructan beta-fructosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80]
synonym: "beta-D-fructan fructohydrolase activity" RELATED [EC:3.2.1.80]
synonym: "exo-beta-D-fructosidase activity" EXACT []
synonym: "exo-beta-fructosidase activity" EXACT []
synonym: "fructan b-fructosidase activity" EXACT []
synonym: "fructan exohydrolase activity" EXACT []
synonym: "fructanase activity" RELATED [EC:3.2.1.80]
synonym: "polysaccharide beta-fructofuranosidase activity" EXACT []
xref: EC:3.2.1.80
xref: MetaCyc:3.2.1.80-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051670
name: inulinase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7]
synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT []
synonym: "endo-inulinase activity" EXACT []
synonym: "exoinulinase activity" EXACT []
synonym: "indoinulinase activity" EXACT []
synonym: "inulase activity" EXACT []
xref: EC:3.2.1.7
xref: MetaCyc:3.2.1.7-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051671
name: obsolete induction of autolysin activity in other organism
namespace: biological_process
def: "OBSOLETE. Any process in which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of autolysin activity in another organism" EXACT []
synonym: "activation of autolysis in other organism" NARROW []
synonym: "activation of autolytic activity in other organism" NARROW []
synonym: "induction of autolysin activity in another organism" EXACT [GOC:bf]
synonym: "induction of autolysis in other organism" NARROW []
synonym: "induction of autolytic activity in other organism" NARROW []
synonym: "positive regulation of autolysin activity in another organism" BROAD []
is_obsolete: true

[Term]
id: GO:0051672
name: obsolete catabolism by organism of cell wall peptidoglycan in other organism
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism." [GOC:ai]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolic process of cell wall peptidoglycans of other organism" EXACT []
synonym: "catabolism of cell wall peptidoglycans of other organism" EXACT []
synonym: "cell wall catabolic process in other organism" NARROW []
synonym: "cell wall catabolism in other organism" NARROW []
synonym: "cell wall peptidoglycan catabolic process in another organism" EXACT []
is_obsolete: true

[Term]
id: GO:0051673
name: disruption of plasma membrane integrity in another organism
namespace: biological_process
alt_id: GO:0044662
def: "The disruption of the cell membrane of another organism, leading to damage or temporary subversion of the membrane." [GOC:ai]
synonym: "cytolysis, by membrane disruption, in other organism" NARROW []
synonym: "disruption by organism of host cell membrane" EXACT []
synonym: "disruption by virus of host cell membrane" NARROW []
synonym: "disruption of membrane integrity in another organism" EXACT []
synonym: "membrane disruption in another organism" NARROW []
synonym: "membrane disruption in other organism" EXACT []
synonym: "perturbation of plasma membrane integrity in another organism" EXACT []
is_a: GO:0140975 ! disruption of cellular anatomical structure in another organism

[Term]
id: GO:0051674
name: localization of cell
namespace: biological_process
def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cell localization" EXACT []
synonym: "establishment and maintenance of cell localization" EXACT []
synonym: "establishment and maintenance of localization of cell" EXACT []
synonym: "localisation of cell" EXACT [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization

[Term]
id: GO:0051675
name: isopullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57]
synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT []
xref: EC:3.2.1.57
xref: MetaCyc:3.2.1.57-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051676
name: pullulan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [PMID:15013381]
synonym: "pullulan metabolism" EXACT []
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0051677
name: pullulan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai]
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0051676 ! pullulan metabolic process

[Term]
id: GO:0051678
name: pullulan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0051676 ! pullulan metabolic process

[Term]
id: GO:0051679
name: 6-alpha-maltosylglucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai, LIGAND:C03367, PubChem_Compound:439991]
synonym: "6-alpha-maltosylglucose metabolism" EXACT []
synonym: "isopanose metabolic process" EXACT []
synonym: "isopanose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0051680
name: 6-alpha-maltosylglucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai]
synonym: "isopanose biosynthesis" EXACT []
synonym: "isopanose biosynthetic process" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process

[Term]
id: GO:0051681
name: 6-alpha-maltosylglucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai]
synonym: "isopanose catabolic process" EXACT []
synonym: "isopanose catabolism" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process

[Term]
id: GO:0051682
name: galactomannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0051069 ! galactomannan metabolic process

[Term]
id: GO:0051683
name: establishment of Golgi localization
namespace: biological_process
def: "The directed movement of the Golgi to a specific location." [GOC:ai]
synonym: "establishment of Golgi apparatus localization" EXACT []
synonym: "establishment of Golgi body localization" EXACT []
synonym: "establishment of Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051645 ! Golgi localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051684
name: maintenance of Golgi location
namespace: biological_process
def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of Golgi apparatus localization" EXACT []
synonym: "maintenance of Golgi body localization" EXACT []
synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051645 ! Golgi localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051685
name: maintenance of ER location
namespace: biological_process
def: "Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of endoplasmic reticulum localization" EXACT []
synonym: "maintenance of ER localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051643 ! endoplasmic reticulum localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051686
name: establishment of ER localization
namespace: biological_process
def: "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai]
synonym: "establishment of endoplasmic reticulum localization" EXACT []
synonym: "establishment of ER localisation" EXACT [GOC:mah]
is_a: GO:0051643 ! endoplasmic reticulum localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051687
name: maintenance of spindle location
namespace: biological_process
def: "Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of spindle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051653 ! spindle localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051688
name: maintenance of plastid location
namespace: biological_process
def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051644 ! plastid localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051691
name: obsolete cellular oligosaccharide metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai]
comment: This term was obsoleted because it is not different from its parent, oligosaccharide metabolic process ; GO:0009311.
synonym: "cellular oligosaccharide metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0009311

[Term]
id: GO:0051692
name: obsolete cellular oligosaccharide catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai]
comment: This term was obsoleted because it is not different from its parent, oligosaccharide catabolic process ; GO:0009313.
synonym: "cellular oligosaccharide breakdown" EXACT []
synonym: "cellular oligosaccharide catabolism" EXACT []
synonym: "cellular oligosaccharide degradation" EXACT []
is_obsolete: true
replaced_by: GO:0009313

[Term]
id: GO:0051693
name: actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "actin capping activity" RELATED []
synonym: "F-actin capping activity" RELATED []
is_a: GO:0030835 ! negative regulation of actin filament depolymerization
is_a: GO:0030837 ! negative regulation of actin filament polymerization

[Term]
id: GO:0051694
name: pointed-end actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "minus-end actin filament capping activity" EXACT []
synonym: "minus-end F-actin capping activity" EXACT []
synonym: "pointed-end actin capping activity" EXACT []
synonym: "pointed-end F-actin capping activity" EXACT []
is_a: GO:0051693 ! actin filament capping

[Term]
id: GO:0051695
name: actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "F-actin uncapping" EXACT []
is_a: GO:0030836 ! positive regulation of actin filament depolymerization

[Term]
id: GO:0051696
name: pointed-end actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "minus end actin filament uncapping" EXACT []
synonym: "minus end F-actin uncapping" EXACT []
synonym: "minus-end actin filament uncapping" EXACT []
synonym: "minus-end F-actin uncapping" EXACT []
synonym: "pointed end actin filament uncapping" EXACT []
synonym: "pointed end F-actin uncapping" EXACT []
synonym: "pointed-end F-actin uncapping" EXACT []
is_a: GO:0051695 ! actin filament uncapping

[Term]
id: GO:0051697
name: protein delipidation
namespace: biological_process
def: "The breakage of covalent bonds to detach lipid groups from a protein." [GOC:ai]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0051698
name: saccharopine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate." [PMID:16233628, RHEA:28210]
synonym: "SAX activity" BROAD []
xref: EC:1.5.3.18
xref: RHEA:28210
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051699
name: obsolete proline oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [GOC:curators]
comment: This term was obsoleted because it represents the same molecular function as proline dehydrogenase activity ; GO:0051699.
is_obsolete: true
replaced_by: GO:0004657

[Term]
id: GO:0051700
name: fructosyl-amino acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628]
synonym: "FAOD activity" EXACT []
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051701
name: biological process involved in interaction with host
namespace: biological_process
alt_id: GO:0044112
alt_id: GO:0044116
alt_id: GO:0044117
alt_id: GO:0044119
alt_id: GO:0044121
alt_id: GO:0044123
alt_id: GO:0044125
def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]
synonym: "growth of symbiont in host" NARROW []
synonym: "growth of symbiont in host cell" NARROW []
synonym: "growth of symbiont in host organelle" NARROW []
synonym: "growth of symbiont in host vacuole" NARROW []
synonym: "interaction with host" EXACT []
is_a: GO:0044403 ! biological process involved in symbiotic interaction

[Term]
id: GO:0051702
name: biological process involved in interaction with symbiont
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]
synonym: "interaction with symbiont" RELATED []
is_a: GO:0044403 ! biological process involved in symbiotic interaction

[Term]
id: GO:0051703
name: biological process involved in intraspecies interaction between organisms
namespace: biological_process
def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "intraspecies interaction between organisms" EXACT []
synonym: "intraspecies interaction with other organisms" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051704
name: obsolete multi-organism process
namespace: biological_process
alt_id: GO:0051706
def: "OBSOLETE. A biological process which involves another organism of the same or different species." [GOC:jl]
comment: This term was obsoleted because it was not a biologically meaningful grouping class.
synonym: "interaction between organisms" EXACT []
synonym: "physiological interaction between organisms" EXACT []
synonym: "physiological interaction with other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0051705
name: obsolete multi-organism behavior
namespace: biological_process
def: "OBSOLETE. Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai]
comment: This term was obsoleted because it was an unnecessary grouping term.
synonym: "behavioral interaction between organisms" EXACT []
synonym: "behavioral interaction with other organism" EXACT []
synonym: "behavioral signaling" NARROW []
synonym: "behavioral signalling" NARROW [GOC:mah]
synonym: "behavioural interaction between organisms" EXACT []
synonym: "behavioural interaction with other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0051707
name: response to other organism
namespace: biological_process
alt_id: GO:0009613
alt_id: GO:0042828
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0051709
name: regulation of killing of cells of another organism
namespace: biological_process
alt_id: GO:0044531
alt_id: GO:0052248
alt_id: GO:0052433
alt_id: GO:0052459
def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
synonym: "modulation by organism of apoptotic process in other organism involved in symbiotic interaction" NARROW []
synonym: "modulation of programmed cell death in other organism" NARROW []
synonym: "modulation of programmed cell death in other organism involved in symbiotic interaction" NARROW []
synonym: "regulation of killing of cells of other organism" EXACT [GOC:bf]
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0035821 ! modulation of process of another organism
relationship: regulates GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051710
name: obsolete regulation of cytolysis in another organism
namespace: biological_process
alt_id: GO:0001902
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "regulation of cytolysis in other organism" EXACT []
synonym: "regulation of cytolysis of cells of another organism" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0031640

[Term]
id: GO:0051711
name: negative regulation of killing of cells of another organism
namespace: biological_process
alt_id: GO:0052490
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
synonym: "down regulation of killing of cells of another organism" EXACT []
synonym: "down-regulation of killing of cells of another organism" EXACT []
synonym: "downregulation of killing of cells of another organism" EXACT []
synonym: "inhibition of killing of cells of another organism" NARROW []
synonym: "negative regulation of killing of cells of other organism" EXACT []
is_a: GO:0031342 ! negative regulation of cell killing
is_a: GO:0051709 ! regulation of killing of cells of another organism
relationship: negatively_regulates GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051712
name: positive regulation of killing of cells of another organism
namespace: biological_process
alt_id: GO:0052330
alt_id: GO:0052388
alt_id: GO:0052501
alt_id: GO:0052518
alt_id: GO:0052529
def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
synonym: "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED []
synonym: "activation of killing of cells of another organism" NARROW []
synonym: "enhancement of other organism programmed cell death by organism" RELATED []
synonym: "positive regulation of killing of cells of other organism" EXACT []
synonym: "stimulation of killing of cells of another organism" NARROW []
synonym: "up regulation of killing of cells of another organism" EXACT []
synonym: "up-regulation of killing of cells of another organism" EXACT []
synonym: "upregulation of killing of cells of another organism" EXACT []
is_a: GO:0031343 ! positive regulation of cell killing
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0051709 ! regulation of killing of cells of another organism
relationship: positively_regulates GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051713
name: obsolete negative regulation of cytolysis in another organism
namespace: biological_process
alt_id: GO:0001903
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism." [GOC:ai]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "down regulation of cytolysis of cells of another organism" EXACT []
synonym: "down-regulation of cytolysis of cells of another organism" EXACT []
synonym: "downregulation of cytolysis of cells of another organism" EXACT []
synonym: "inhibition of cytolysis of cells of another organism" NARROW []
synonym: "negative regulation of cytolysis in other organism" EXACT []
synonym: "negative regulation of cytolysis of cells of another organism" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0051714
name: obsolete positive regulation of cytolysis in another organism
namespace: biological_process
alt_id: GO:0001904
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "activation of cytolysis of cells of another organism" NARROW []
synonym: "positive regulation of cytolysis in other organism" EXACT []
synonym: "positive regulation of cytolysis of cells of another organism" EXACT [GOC:bf]
synonym: "stimulation of cytolysis of cells of another organism" NARROW []
synonym: "up regulation of cytolysis of cells of another organism" EXACT []
synonym: "up-regulation of cytolysis of cells of another organism" EXACT []
synonym: "upregulation of cytolysis of cells of another organism" EXACT []
is_obsolete: true
consider: GO:0031640

[Term]
id: GO:0051715
name: cytolysis in another organism
namespace: biological_process
alt_id: GO:0001901
alt_id: GO:0044649
def: "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai, PMID:22484288]
synonym: "cytolysis in other organism" EXACT []
synonym: "cytolysis of cells of another organism" EXACT [GOC:bf]
synonym: "envenomation resulting in cytolysis in another organism" NARROW []
synonym: "envenomation resulting in cytolysis in other organism" NARROW []
is_a: GO:0019835 ! cytolysis
is_a: GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051716
name: cellular response to stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051717
name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate." [RHEA:77155]
synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" RELATED [EC:2.7.1.-]
synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" RELATED [EC:2.7.1.-]
synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" RELATED [EC:2.7.1.-]
xref: MetaCyc:3.1.3.62-RXN
xref: Reactome:R-HSA-1855200 "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen"
xref: Reactome:R-HSA-1855205 "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol"
xref: RHEA:77155
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0051718
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)." [PMID:15689527]
synonym: "HpaII methylase" NARROW [EC:2.1.1.37]
synonym: "HpaII' methylase" NARROW [EC:2.1.1.37]
synonym: "M.BsuRIa" NARROW [EC:2.1.1.37]
synonym: "M.BsuRIb" NARROW [EC:2.1.1.37]
xref: Reactome:R-HSA-5334151 "DNMT1 methylates cytosine in hemimethylated DNA"
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051719
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [PMID:15689527]
xref: Reactome:R-HSA-5334097 "DNMT3B:DNMT3L methylates cytosine in DNA"
xref: Reactome:R-HSA-5334152 "DNMT3A:DNMT3L methylates cytosine in DNA"
xref: Reactome:R-HSA-9845308 "DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA"
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051720
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [PMID:15689527]
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051721
name: protein phosphatase 2A binding
namespace: molecular_function
def: "Binding to protein phosphatase 2A." [GOC:ai]
synonym: "protein phosphatase 2 binding" RELATED [GOC:rl]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0051722
name: protein C-terminal methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216]
synonym: "protein phosphatase methylesterase activity" NARROW []
xref: Reactome:R-HSA-8856951 "PP2A demethylation by PPME1"
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0051723
name: protein methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai]
synonym: "PME activity" RELATED [EC:2.7.1.-]
synonym: "protein carboxyl methylesterase activity" RELATED [EC:2.7.1.-]
synonym: "protein carboxylic ester hydrolase activity" EXACT []
synonym: "protein methyl-esterase activity" RELATED [EC:2.7.1.-]
xref: Reactome:R-HSA-5367022 "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2"
is_a: GO:0052689 ! carboxylic ester hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0051724
name: NAD transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901368
def: "Enables the transfer of NAD from one side of a membrane to the other." [GOC:TermGenie]
comment: NAD carrier
synonym: "NAD (oxidized) transporter activity" EXACT []
synonym: "NAD (reduced) transporter activity" EXACT []
synonym: "NAD transporter activity" RELATED []
synonym: "NAD+ transporter activity" EXACT []
synonym: "NADH transporter activity" EXACT []
synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "oxidized NAD transporter activity" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "reduced NAD transporter activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity

[Term]
id: GO:0051725
name: protein de-ADP-ribosylation
namespace: biological_process
def: "The process of removing one or more ADP-ribose residues from a protein." [GOC:ai]
synonym: "poly(ADP-ribose) removal from protein" EXACT []
synonym: "protein amino acid de-ADP-ribosylation" EXACT [GOC:bf]
synonym: "protein poly(ADP-ribose) catabolic process" EXACT []
synonym: "protein poly(ADP-ribose) catabolism" EXACT []
synonym: "protein poly(ADP-ribose) degradation" EXACT []
synonym: "protein poly(ADP-ribose) hydrolysis" EXACT []
synonym: "removal of ADP-ribose from protein" EXACT []
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0051726
name: regulation of cell cycle
namespace: biological_process
alt_id: GO:0000074
alt_id: GO:0007050
alt_id: GO:0071156
alt_id: GO:0071157
alt_id: GO:0071158
alt_id: GO:0071850
def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah]
synonym: "cell cycle arrest" NARROW []
synonym: "cell cycle modulation" EXACT []
synonym: "cell cycle regulation" EXACT []
synonym: "cell cycle regulator" RELATED []
synonym: "control of cell cycle progression" EXACT []
synonym: "mitotic cell cycle arrest" NARROW []
synonym: "modulation of cell cycle progression" EXACT []
synonym: "negative regulation of cell cycle arrest" NARROW []
synonym: "positive regulation of cell cycle arrest" NARROW []
synonym: "regulation of cell cycle arrest" NARROW []
synonym: "regulation of cell cycle progression" EXACT []
synonym: "regulation of progression through cell cycle" EXACT []
synonym: "tumor suppressor" RELATED []
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007049 ! cell cycle

[Term]
id: GO:0051727
name: obsolete cell cycle switching, meiotic to mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. The process in which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai, GOC:mtg_cell_cycle]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "cell cycle switching, meiosis to mitosis" NARROW []
synonym: "cell cycle switching, meiotic to mitotic cell cycle" EXACT []
synonym: "conversion to mitosis" NARROW []
synonym: "conversion to mitotic cell cycle" EXACT []
synonym: "entry into mitosis" NARROW []
synonym: "entry into mitotic cell cycle" EXACT []
synonym: "initiation of mitosis" NARROW []
synonym: "initiation of mitotic cell cycle" EXACT []
synonym: "mitotic entry" NARROW []
is_obsolete: true

[Term]
id: GO:0051728
name: cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
alt_id: GO:0042061
def: "The process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai, GOC:mtg_cell_cycle]
synonym: "cell cycle switching, mitosis to meiosis" NARROW []
synonym: "conversion to meiosis" NARROW []
synonym: "conversion to meiotic cell cycle" EXACT []
synonym: "entry into meiosis" NARROW []
synonym: "entry into meiotic cell cycle" EXACT []
synonym: "initiation of meiosis" NARROW []
synonym: "initiation of meiotic cell cycle" EXACT []
synonym: "meiotic entry" NARROW []
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0060184 ! cell cycle switching

[Term]
id: GO:0051729
name: germline cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
def: "The process in which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
synonym: "germline cell cycle switching, mitosis to meiosis" NARROW []
synonym: "germline conversion to meiosis" NARROW []
synonym: "germline conversion to meiotic cell cycle" EXACT []
synonym: "germline entry into meiosis" NARROW []
synonym: "germline entry into meiotic cell cycle" EXACT []
synonym: "germline initiation of meiosis" NARROW []
synonym: "germline initiation of meiotic cell cycle" EXACT []
synonym: "germline meiotic entry" NARROW []
is_a: GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle

[Term]
id: GO:0051730
name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [PMID:8428918]
synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT []
synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP-dependent RNA kinase activity" EXACT []
is_a: GO:0051735 ! GTP-dependent polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051731
name: polynucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]
synonym: "5'-dephosphopolynucleotide kinase activity" EXACT []
synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT []
synonym: "PNK" RELATED []
synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT []
synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT []
synonym: "polynucleotide kinase activity" BROAD []
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0051732
name: obsolete polyribonucleotide kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [GOC:curators]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT []
synonym: "5'-hydroxyl RNA kinase activity" EXACT []
synonym: "RNA 5'-hydroxyl kinase activity" EXACT []
synonym: "RNA kinase activity" EXACT []
is_obsolete: true
consider: GO:0051736

[Term]
id: GO:0051733
name: obsolete polydeoxyribonucleotide kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [GOC:curators]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "DNA 5'-hydroxyl kinase activity" EXACT []
synonym: "DNA kinase activity" EXACT []
is_obsolete: true
consider: GO:0046404
consider: GO:0051737

[Term]
id: GO:0051734
name: ATP-dependent polynucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
synonym: "ATP-dependent polynucleotide kinase activity" RELATED []
synonym: "polynucleotide kinase activity" BROAD []
xref: EC:2.7.1.78
is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051735
name: GTP-dependent polynucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]
synonym: "GTP-dependent polynucleotide kinase activity" BROAD []
is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051736
name: ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [RHEA:54580]
synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT []
synonym: "ATP-dependent RNA kinase activity" EXACT []
synonym: "polyribonucleotide 5'-hydroxyl-kinase activity" BROAD []
xref: RHEA:54580
is_a: GO:0051734 ! ATP-dependent polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051737
name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [PMID:8428918]
synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP-dependent DNA kinase activity" EXACT []
synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT []
is_a: GO:0051735 ! GTP-dependent polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051738
name: xanthophyll binding
namespace: molecular_function
def: "Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743]
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0031409 ! pigment binding

[Term]
id: GO:0051740
name: ethylene binding
namespace: molecular_function
def: "Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai]
synonym: "ethene binding" EXACT []
is_a: GO:0072328 ! alkene binding

[Term]
id: GO:0051741
name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542]
synonym: "MPBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2542
xref: RHEA:37979
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0051742
name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762]
synonym: "MSBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2762
xref: RHEA:37999
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0051743
name: red chlorophyll catabolite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence." [PMID:10743659]
synonym: "RCC reductase activity" EXACT []
xref: MetaCyc:RXN-7741
xref: RHEA:24752
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0051744
name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72]
xref: MetaCyc:RXN1F-72
xref: RHEA:48884
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051745
name: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity
namespace: molecular_function
def: "Catalyzes the conversion of (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + 2 reduced [2Fe-2S]-[ferredoxin] to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) releasing H2O + 2 oxidized [2Fe-2S]-[ferredoxin]. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.7.4, GOC:pg]
synonym: "4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity" EXACT []
synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT []
xref: EC:1.17.7.4
xref: KEGG_REACTION:R05884
xref: MetaCyc:ISPH2-RXN
is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

[Term]
id: GO:0051746
name: thalianol synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655, RHEA:26160]
xref: EC:5.4.99.31
xref: RHEA:26160
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0051747
name: cytosine C-5 DNA demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851]
synonym: "DNA demethylase activity" BROAD [PMID:10050851]
synonym: "DNA methyltransferase activity acting on cytosine C-5" EXACT []
synonym: "hydrolytic DNA demethylase activity" BROAD []
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0035514 ! DNA demethylase activity

[Term]
id: GO:0051748
name: UTP-monosaccharide-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166]
synonym: "PsUSP" RELATED [EC:2.7.7.64]
synonym: "UDP-monosaccharide diphosphorylase activity" EXACT []
synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT []
synonym: "UDP-sugar pyrophosphorylase activity" RELATED [EC:2.7.7.64]
synonym: "USP" RELATED [EC:2.7.7.64]
xref: EC:2.7.7.64
xref: MetaCyc:2.7.7.64-RXN
xref: RHEA:13205
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0051749
name: indole acetic acid carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896]
synonym: "IAA carboxyl methyltransferase activity" EXACT []
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0051750
name: delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity
namespace: molecular_function
alt_id: GO:0008416
def: "Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA." [PMID:11278886, PMID:16040662, RHEA:45240]
synonym: "delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase activity" EXACT []
synonym: "delta3,5-delta2,4-dienoyl-CoA isomerase activity" EXACT []
synonym: "delta5-delta2,4-dienoyl-CoA isomerase activity" RELATED []
xref: EC:5.3.3.21
xref: RHEA:45240
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0051751
name: alpha-1,4-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage." [PMID:15772281]
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0051752
name: phosphoglucan, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-alpha-glucosyl](n) + n AMP + 2n H+ + n phosphate." [PMID:15618411, RHEA:10256]
synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" RELATED [EC:2.7.9.5]
synonym: "OK1" RELATED [EC:2.7.9.5]
synonym: "PWD" RELATED [EC:2.7.9.5]
xref: EC:2.7.9.5
xref: MetaCyc:2.7.9.5-RXN
xref: RHEA:10256
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0051753
name: mannan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan." [PMID:14726589]
synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW []
synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT []
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0051754
name: meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576]
synonym: "centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf]
synonym: "meiotic sister chromatid cohesion at centromere" EXACT []
synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT []
is_a: GO:0051177 ! meiotic sister chromatid cohesion
is_a: GO:0070601 ! centromeric sister chromatid cohesion

[Term]
id: GO:0051755
name: meiotic sister chromatid arm separation
namespace: biological_process
def: "The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [GOC:ai]
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051757 ! meiotic sister chromatid separation

[Term]
id: GO:0051756
name: meiotic sister chromatid centromere separation
namespace: biological_process
def: "The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
is_a: GO:0034510 ! centromere separation
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation
relationship: part_of GO:0051757 ! meiotic sister chromatid separation

[Term]
id: GO:0051757
name: meiotic sister chromatid separation
namespace: biological_process
def: "The process in which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
synonym: "meiotic sister chromatid resolution" EXACT [GOC:mah]
is_a: GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0051758
name: homologous chromosome movement towards spindle pole in meiosis I anaphase
namespace: biological_process
def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I anaphase." [GOC:ai]
synonym: "homologous chromosome movement towards spindle pole during meiosis I" RELATED [GOC:dph, GOC:tb]
synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0051759
name: sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation
namespace: biological_process
def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai]
synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT []
synonym: "sister chromosome movement towards spindle pole during meiosis II" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0051760
name: obsolete meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "OBSOLETE. The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576]
comment: The reason for obsoletion is that this term was added in error.
synonym: "meiotic sister chromatid cohesion along arms" EXACT []
synonym: "sister chromatid cohesion along arms at meiosis I" EXACT []
is_obsolete: true
replaced_by: GO:0010789

[Term]
id: GO:0051761
name: sesquiterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
synonym: "sesquiterpene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0051762
name: sesquiterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:0051763
name: sesquiterpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:0051764
name: actin crosslink formation
namespace: biological_process
def: "The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]
comment: See also the molecular function term 'protein binding, bridging ; GO:0030674'.
synonym: "actin bundling" RELATED []
synonym: "actin crosslinking" EXACT []
synonym: "bridging actin filaments" NARROW []
synonym: "formation of actin crosslink" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0051765
name: inositol tetrakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai]
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0051766
name: inositol trisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP + H+." [GOC:ai]
synonym: "IP3K" BROAD []
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0051767
name: obsolete nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051768
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [GOC:ai]
comment: The reason for obsoletion is that this term refers to a gene product.
synonym: "brain nitric-oxide synthase biosynthetic process" NARROW [GOC:bf]
synonym: "endothelial nitric-oxide synthase biosynthetic process" NARROW [GOC:bf]
synonym: "inducible nitric-oxide synthase biosynthetic process" NARROW [GOC:bf]
synonym: "nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "nitric-oxide synthase-1 biosynthetic process" NARROW [GOC:bf]
synonym: "nitric-oxide synthase-2 biosynthetic process" NARROW [GOC:bf]
synonym: "nitric-oxide synthase-3 biosynthetic process" NARROW [GOC:bf]
synonym: "NO synthase biosynthesis" EXACT []
synonym: "NO synthase biosynthetic process" EXACT []
synonym: "NOS biosynthesis" EXACT []
synonym: "NOS biosynthetic process" EXACT []
synonym: "NOS1 biosynthesis" NARROW [GOC:bf]
synonym: "NOS2 biosynthesis" NARROW [GOC:bf]
synonym: "NOS2 synthase biosynthesis" NARROW []
synonym: "NOS2 synthase biosynthetic process" NARROW []
synonym: "NOS3 biosynthesis" NARROW [GOC:bf]
is_obsolete: true

[Term]
id: GO:0051769
name: obsolete regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051772
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai]
comment: The reason for obsoletion is that this term refers to a gene product.
synonym: "regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "regulation of nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "regulation of NO synthase biosynthesis" EXACT []
synonym: "regulation of NO synthase biosynthetic process" EXACT []
synonym: "regulation of NOS biosynthesis" EXACT []
synonym: "regulation of NOS biosynthetic process" EXACT []
synonym: "regulation of NOS2 synthase biosynthesis" NARROW []
synonym: "regulation of NOS2 synthase biosynthetic process" NARROW []
is_obsolete: true

[Term]
id: GO:0051770
name: obsolete positive regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051773
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme." [GOC:ai]
comment: The reason for obsoletion is that this term refers to a gene product.
synonym: "activation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "activation of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "positive regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "positive regulation of NO synthase biosynthesis" EXACT []
synonym: "positive regulation of NO synthase biosynthetic process" EXACT []
synonym: "positive regulation of NOS biosynthesis" EXACT []
synonym: "positive regulation of NOS biosynthetic process" EXACT []
synonym: "positive regulation of NOS2 synthase biosynthesis" NARROW []
synonym: "positive regulation of NOS2 synthase biosynthetic process" NARROW []
synonym: "stimulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "stimulation of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "up regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "up regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "up-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "up-regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "upregulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "upregulation of nitric-oxide synthase biosynthetic process" EXACT []
is_obsolete: true

[Term]
id: GO:0051771
name: obsolete negative regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051774
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai]
comment: The reason for obsoletion is that this term refers to a gene product.
synonym: "down regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "down regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "down-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "down-regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "downregulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "downregulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "inhibition of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "inhibition of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "negative regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "negative regulation of NO synthase biosynthesis" EXACT []
synonym: "negative regulation of NO synthase biosynthetic process" EXACT []
synonym: "negative regulation of NOS biosynthesis" EXACT []
synonym: "negative regulation of NOS biosynthetic process" EXACT []
synonym: "negative regulation of NOS2 synthase biosynthesis" NARROW []
synonym: "negative regulation of NOS2 synthase biosynthetic process" NARROW []
is_obsolete: true

[Term]
id: GO:0051775
name: response to redox state
namespace: biological_process
alt_id: GO:0006980
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039]
synonym: "redox signal response" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051776
name: detection of redox state
namespace: biological_process
def: "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039]
synonym: "redox sensing" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0051777
name: ent-kaurenoic acid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction:ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Catalyzes three successive oxidations of ent-kaurenoic acid." [RHEA:33219]
synonym: "ent-kaurenoate oxidase activity" RELATED []
synonym: "ent-kaurenoic acid oxidase activity" RELATED []
xref: EC:1.14.14.107
xref: RHEA:33219
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0051778
name: obsolete ent-7-alpha-hydroxykaurenoate oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160]
comment: The reason for obsoletion is that the term is part of a 3-step reaction defined by EC:1.14.14.107.
is_obsolete: true
consider: GO:0051777

[Term]
id: GO:0051779
name: obsolete gibberellin 12-aldehyde oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161]
comment: The reason for obsoletion is that the term is part of a 3-step reaction defined by EC:1.14.14.107.
synonym: "GA12-aldehyde oxidase activity" EXACT []
is_obsolete: true
consider: GO:0051777

[Term]
id: GO:0051780
name: behavioral response to nutrient
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai]
synonym: "behavioural response to nutrient" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0007584 ! response to nutrient

[Term]
id: GO:0051781
name: positive regulation of cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
synonym: "activation of cell division" NARROW []
synonym: "stimulation of cell division" NARROW []
synonym: "up regulation of cell division" EXACT []
synonym: "up-regulation of cell division" EXACT []
synonym: "upregulation of cell division" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
relationship: positively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051782
name: negative regulation of cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai]
synonym: "down regulation of cell division" EXACT []
synonym: "down-regulation of cell division" EXACT []
synonym: "downregulation of cell division" EXACT []
synonym: "inhibition of cell division" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
relationship: negatively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051783
name: regulation of nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051784
name: negative regulation of nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "down regulation of nuclear division" EXACT []
synonym: "down-regulation of nuclear division" EXACT []
synonym: "downregulation of nuclear division" EXACT []
synonym: "inhibition of nuclear division" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
relationship: negatively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051785
name: positive regulation of nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "activation of nuclear division" NARROW []
synonym: "stimulation of nuclear division" NARROW []
synonym: "up regulation of nuclear division" EXACT []
synonym: "up-regulation of nuclear division" EXACT []
synonym: "upregulation of nuclear division" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
relationship: positively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051786
name: all-trans-retinol 13,14-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23, RHEA:19193]
synonym: "(13,14)-all-trans-retinol saturase activity" EXACT []
synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT []
synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT []
synonym: "retinol saturase activity" RELATED [EC:1.3.99.23]
synonym: "RetSat activity" RELATED [EC:1.3.99.23]
xref: EC:1.3.99.23
xref: KEGG_REACTION:R07163
xref: MetaCyc:1.3.99.23-RXN
xref: Reactome:R-HSA-8956427 "RETSAT reduces atROL to at-13,14-dhROL"
xref: RHEA:19193
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0051787
name: misfolded protein binding
namespace: molecular_function
def: "Binding to a misfolded protein." [GOC:ai]
xref: Reactome:R-HSA-5324632 "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051788
name: response to misfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators]
is_a: GO:0035966 ! response to topologically incorrect protein

[Term]
id: GO:0051789
name: obsolete response to protein
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:ai]
comment: This term was made obsolete because more specific terms exist.
synonym: "response to protein" EXACT []
synonym: "response to protein stimulus" EXACT [GOC:dos]
is_obsolete: true
consider: GO:0006986
consider: GO:0009725
consider: GO:0034097
consider: GO:0051788
consider: GO:0070848

[Term]
id: GO:0051790
name: short-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [Wikipedia:Fatty_acid_metabolism]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "short chain fatty acid biosynthesis" EXACT []
synonym: "short chain fatty acid biosynthetic process" EXACT []
synonym: "short-chain fatty acid anabolism" EXACT []
synonym: "short-chain fatty acid biosynthesis" EXACT []
synonym: "short-chain fatty acid formation" EXACT []
synonym: "short-chain fatty acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0051791
name: medium-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolisms]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "medium chain fatty acid metabolic process" EXACT []
synonym: "medium chain fatty acid metabolism" EXACT []
synonym: "medium-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0051792
name: medium-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "medium chain fatty acid biosynthesis" EXACT []
synonym: "medium chain fatty acid biosynthetic process" EXACT []
synonym: "medium-chain fatty acid anabolism" EXACT []
synonym: "medium-chain fatty acid biosynthesis" EXACT []
synonym: "medium-chain fatty acid formation" EXACT []
synonym: "medium-chain fatty acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0051793
name: medium-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "medium chain fatty acid catabolic process" EXACT []
synonym: "medium chain fatty acid catabolism" EXACT []
synonym: "medium-chain fatty acid breakdown" EXACT []
synonym: "medium-chain fatty acid catabolism" EXACT []
synonym: "medium-chain fatty acid degradation" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0051794
name: regulation of timing of catagen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "regulation of catagen" RELATED []
is_a: GO:0048819 ! regulation of hair follicle maturation
relationship: regulates GO:0042637 ! catagen

[Term]
id: GO:0051795
name: positive regulation of timing of catagen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "activation of catagen" NARROW []
synonym: "positive regulation of catagen" RELATED []
synonym: "stimulation of catagen" NARROW []
synonym: "up regulation of catagen" RELATED []
synonym: "up-regulation of catagen" RELATED []
synonym: "upregulation of catagen" RELATED []
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051794 ! regulation of timing of catagen
relationship: positively_regulates GO:0042637 ! catagen

[Term]
id: GO:0051796
name: negative regulation of timing of catagen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "down regulation of catagen" RELATED []
synonym: "down-regulation of catagen" RELATED []
synonym: "downregulation of catagen" RELATED []
synonym: "inhibition of catagen" NARROW []
synonym: "negative regulation of catagen" RELATED []
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051794 ! regulation of timing of catagen
relationship: negatively_regulates GO:0042637 ! catagen

[Term]
id: GO:0051797
name: regulation of hair follicle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai]
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051798
name: positive regulation of hair follicle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai]
synonym: "activation of hair follicle development" NARROW []
synonym: "stimulation of hair follicle development" NARROW []
synonym: "up regulation of hair follicle development" EXACT []
synonym: "up-regulation of hair follicle development" EXACT []
synonym: "upregulation of hair follicle development" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051797 ! regulation of hair follicle development
relationship: positively_regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051799
name: negative regulation of hair follicle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development." [GOC:ai]
synonym: "down regulation of hair follicle development" EXACT []
synonym: "down-regulation of hair follicle development" EXACT []
synonym: "downregulation of hair follicle development" EXACT []
synonym: "inhibition of hair follicle development" NARROW []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051797 ! regulation of hair follicle development
relationship: negatively_regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051800
name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [GOC:bf, PMID:9811831]
synonym: "PTEN activity" BROAD []
xref: Reactome:R-HSA-1676149 "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane"
xref: Reactome:R-HSA-1676204 "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane"
is_a: GO:0106017 ! phosphatidylinositol-3,4-bisphosphate phosphatase activity

[Term]
id: GO:0051801
name: obsolete cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0051802
name: obsolete regulation of cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0051803
name: obsolete negative regulation of cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "down regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED []
synonym: "downregulation of cytolysis of cells in other organism during symbiotic interaction" RELATED []
synonym: "inhibition of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0051804
name: obsolete positive regulation of cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "activation of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "positive regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
synonym: "stimulation of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "up regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "upregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0051814
name: obsolete movement in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it represented both a process and a location.
synonym: "movement in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "movement within other organism during symbiotic interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0051815
name: obsolete migration in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it represented both a process and a location.
synonym: "migration in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "migration within other organism during symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0051816
name: obsolete acquisition of nutrients from other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it represented an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0051817
name: obsolete modulation of process of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modification of morphology or physiology of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modification of morphology or physiology of other organism involved in symbiotic interaction" RELATED []
synonym: "modulation of biological process of other organism involved in symbiotic interaction" RELATED []
synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" RELATED []
synonym: "regulation of morphology of other organism during symbiotic interaction" NARROW []
synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" RELATED []
synonym: "regulation of physiological process in other organism during symbiotic interaction" NARROW []
synonym: "regulation of physiology of other organism during symbiotic interaction" NARROW []
is_obsolete: true

[Term]
id: GO:0051818
name: obsolete disruption of cells of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "disruption of cells of other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0051819
name: symbiont-mediated induction of tumor or growth in host
namespace: biological_process
alt_id: GO:0044005
alt_id: GO:0044006
alt_id: GO:0051820
def: "The process in which a symbiont causes the formation of a mass of cells in a host organism. While these growths are often called nodules, they are not formed as nitrogen-fixing structures, but rather to provide an environment for the symbiont to grow. In this sense they are parasitic structures rather than mutualistic." [GOC:pg]
synonym: "induction by symbiont in host of tumor, nodule, or growth" RELATED []
synonym: "induction by symbiont in host of tumor, nodule, or growth containing transformed cells" RELATED []
synonym: "induction by symbiont of nodulation, tumor or growth in host" RELATED []
synonym: "induction by symbiont of tumor or growth in host" EXACT []
synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction" RELATED []
synonym: "induction of tumor, nodule, or growth in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "induction of tumor, nodule, or growth in other organism involved in symbiotic interaction" RELATED []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0051821
name: obsolete dissemination or transmission of organism from other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism." [GOC:cc]
comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont.
synonym: "dissemination or transmission of organism from other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0051822
name: obsolete dissemination or transmission of organism from other organism by vector involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal." [GOC:cc]
comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont.
synonym: "dissemination or transmission of organism from other organism by vector during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0051823
name: regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123]
synonym: "regulation of synaptic structural plasticity" EXACT []
is_a: GO:0050807 ! regulation of synapse organization

[Term]
id: GO:0051826
name: negative regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity." [GOC:ai]
synonym: "down regulation of synapse structural plasticity" EXACT []
synonym: "down-regulation of synapse structural plasticity" EXACT []
synonym: "downregulation of synapse structural plasticity" EXACT []
synonym: "inhibition of synapse structural plasticity" NARROW []
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051823 ! regulation of synapse structural plasticity

[Term]
id: GO:0051827
name: obsolete growth or development on or near surface of other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development on or near surface of other organism during symbiotic interaction" EXACT []
is_obsolete: true
consider: GO:0044111

[Term]
id: GO:0051831
name: obsolete growth or development in other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development in other organism during symbiotic interaction" EXACT []
synonym: "growth or development within other organism during symbiotic interaction" EXACT []
synonym: "invasive growth" BROAD []
is_obsolete: true

[Term]
id: GO:0051835
name: positive regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity." [GOC:ai]
synonym: "activation of synapse structural plasticity" NARROW []
synonym: "stimulation of synapse structural plasticity" NARROW []
synonym: "up regulation of synapse structural plasticity" EXACT []
synonym: "up-regulation of synapse structural plasticity" EXACT []
synonym: "upregulation of synapse structural plasticity" EXACT []
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051823 ! regulation of synapse structural plasticity

[Term]
id: GO:0051838
name: cytolysis by host of symbiont cells
namespace: biological_process
def: "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
is_a: GO:0051873 ! killing by host of symbiont cells

[Term]
id: GO:0051839
name: obsolete regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it has been used inconsistently.
is_obsolete: true
consider: GO:0051873

[Term]
id: GO:0051840
name: obsolete negative regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "down regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "down-regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "downregulation by host of cytolysis of symbiont cells" EXACT []
synonym: "inhibition by host of cytolysis of symbiont cells" NARROW []
is_obsolete: true

[Term]
id: GO:0051841
name: obsolete positive regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it has been used inconsistently.
synonym: "activation by host of cytolysis of symbiont cells" NARROW []
synonym: "stimulation by host of cytolysis of symbiont cells" NARROW []
synonym: "up regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "up-regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "upregulation by host of cytolysis of symbiont cells" EXACT []
is_obsolete: true
consider: GO:0051873

[Term]
id: GO:0051842
name: obsolete evasion or tolerance of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mb]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "evasion or tolerance of symbiont immune response" EXACT []
synonym: "immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051843
name: obsolete evasion or tolerance of symbiont defense response
namespace: biological_process
def: "OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mah]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "evasion of symbiont defence response" EXACT []
synonym: "evasion or tolerance of symbiont defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0051844
name: translocation of peptides or proteins into symbiont
namespace: biological_process
def: "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "transport of peptides or proteins into symbiont" EXACT []
is_a: GO:0051862 ! translocation of molecules into symbiont

[Term]
id: GO:0051845
name: obsolete passive evasion of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "passive evasion of symbiont immune response" EXACT []
synonym: "passive immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051846
name: obsolete active evasion of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response" EXACT []
synonym: "active immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051847
name: obsolete active evasion of symbiont immune response via regulation of symbiont complement system
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response via regulation of symbiont complement system" EXACT []
synonym: "active immune evasion via modulation of symbiont complement system" EXACT []
synonym: "active immune evasion via regulation of symbiont complement system" EXACT []
is_obsolete: true

[Term]
id: GO:0051848
name: obsolete active evasion of symbiont immune response via regulation of symbiont cytokine network
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response via regulation of symbiont cytokine network" EXACT []
synonym: "active immune evasion via modulation of symbiont cytokine network" EXACT []
synonym: "active immune evasion via regulation of symbiont cytokine network" EXACT []
is_obsolete: true

[Term]
id: GO:0051849
name: obsolete active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation" EXACT []
synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway" EXACT []
synonym: "active immune evasion via modulation of symbiont antigen processing and presentation" EXACT []
synonym: "active immune evasion via modulation of symbiont antigen processing/presentation" EXACT []
synonym: "active immune evasion via regulation of symbiont antigen processing or presentation" EXACT []
is_obsolete: true

[Term]
id: GO:0051850
name: acquisition of nutrients from symbiont
namespace: biological_process
def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
is_a: GO:0051702 ! biological process involved in interaction with symbiont

[Term]
id: GO:0051851
name: modulation by host of symbiont process
namespace: biological_process
def: "The process in which an host alters or subverts a process in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "modification by host of symbiont morphology or physiology" RELATED []
is_a: GO:0051702 ! biological process involved in interaction with symbiont

[Term]
id: GO:0051853
name: obsolete induction in symbiont of tumor, nodule, or growth
namespace: biological_process
def: "OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "induction in symbiont of tumor, nodule, or growth" EXACT []
is_obsolete: true

[Term]
id: GO:0051854
name: obsolete induction in symbiont of tumor, nodule, or growth containing transformed cells
namespace: biological_process
def: "OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "induction in symbiont of tumor, nodule, or growth containing transformed cells" EXACT []
is_obsolete: true

[Term]
id: GO:0051857
name: obsolete growth or development of organism on or near symbiont surface
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "growth or development of organism during interaction with symbiont" EXACT []
synonym: "growth or development of organism on or near symbiont surface" EXACT []
is_obsolete: true
consider: GO:0032502

[Term]
id: GO:0051858
name: obsolete avoidance of symbiont defenses
namespace: biological_process
def: "OBSOLETE. Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction.
is_obsolete: true

[Term]
id: GO:0051859
name: obsolete suppression of symbiont defenses
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction.
is_obsolete: true

[Term]
id: GO:0051860
name: obsolete evasion or tolerance of symbiont defenses
namespace: biological_process
def: "OBSOLETE. The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction.
is_obsolete: true

[Term]
id: GO:0051861
name: glycolipid binding
namespace: molecular_function
def: "Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [PMID:19635802]
is_a: GO:0008289 ! lipid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0051862
name: translocation of molecules into symbiont
namespace: biological_process
def: "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "transport of molecules into symbiont" EXACT []
is_a: GO:0051702 ! biological process involved in interaction with symbiont

[Term]
id: GO:0051863
name: obsolete translocation of DNA into symbiont
namespace: biological_process
def: "OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "translocation of DNA into symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0051864
name: histone H3K36 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16362057]
synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT []
synonym: "histone demethylase activity (H3-K36 specific)" EXACT []
synonym: "histone H3-K36 demethylase activity" EXACT []
synonym: "histone H3-lysine-36 demethylase activity" EXACT []
synonym: "histone H3-methyl-lysine-36 demethylase activity" EXACT []
synonym: "histone-lysine (H3-K36) demethylase activity" EXACT []
synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT []
synonym: "histone-lysine(H3-K36) demethylase activity" EXACT []
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0141052 ! histone H3 demethylase activity

[Term]
id: GO:0051865
name: protein autoubiquitination
namespace: biological_process
def: "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]
synonym: "protein auto-ubiquitination" EXACT []
synonym: "protein auto-ubiquitinylation" EXACT []
synonym: "protein autoubiquitinylation" EXACT []
synonym: "protein self-ubiquitination" EXACT []
synonym: "protein self-ubiquitinylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0051866
name: general adaptation syndrome
namespace: biological_process
alt_id: GO:0051868
def: "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses." [PMID:14847556, Wikipedia:General_adaptation_syndrome]
synonym: "general adaptation syndrome, physiological process" EXACT []
synonym: "general adaptation syndrome, physiological response" EXACT []
synonym: "physiological process during general adaptation syndrome" EXACT []
synonym: "physiological response during general adaptation syndrome" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0051867
name: general adaptation syndrome, behavioral process
namespace: biological_process
def: "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus." [GOC:ai]
synonym: "behavioral process during general adaptation syndrome" EXACT []
synonym: "behavioral response during general adaptation syndrome" EXACT []
synonym: "behavioural process during general adaptation syndrome" EXACT []
synonym: "behavioural response during general adaptation syndrome" EXACT []
synonym: "general adaptation syndrome, behavioral response" EXACT []
synonym: "general adaptation syndrome, behavioural process" EXACT []
synonym: "general adaptation syndrome, behavioural response" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0051866 ! general adaptation syndrome

[Term]
id: GO:0051870
name: methotrexate binding
namespace: molecular_function
def: "Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0033218 ! amide binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051871
name: dihydrofolic acid binding
namespace: molecular_function
def: "Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544]
synonym: "DHF binding" RELATED []
synonym: "dihydrofolate binding" RELATED []
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051872
name: sphingosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ai]
synonym: "(4E)-sphing-4-enine catabolic process" EXACT []
synonym: "(4E)-sphing-4-enine catabolism" EXACT []
synonym: "sphing-4-enine catabolic process" EXACT []
synonym: "sphing-4-enine catabolism" EXACT []
is_a: GO:0006670 ! sphingosine metabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0046521 ! sphingoid catabolic process

[Term]
id: GO:0051873
name: killing by host of symbiont cells
namespace: biological_process
alt_id: GO:0051852
def: "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
synonym: "disruption by host of symbiont cells" BROAD []
is_a: GO:0031640 ! killing of cells of another organism
is_a: GO:0051702 ! biological process involved in interaction with symbiont
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0051874
name: sphinganine-1-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
synonym: "dihydrosphingosine-1-phosphate catabolic process" EXACT []
synonym: "dihydrosphingosine-1-phosphate catabolism" EXACT []
is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0051875
name: pigment granule localization
namespace: biological_process
def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
relationship: part_of GO:0033059 ! cellular pigmentation

[Term]
id: GO:0051876
name: pigment granule dispersal
namespace: biological_process
def: "The directed movement of pigment granules within a cell towards the cell periphery." [GOC:mh]
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051877
name: pigment granule aggregation in cell center
namespace: biological_process
def: "The directed movement of dispersed pigment granules towards the center of the cell." [GOC:mh]
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051878
name: lateral element assembly
namespace: biological_process
def: "The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007130 ! synaptonemal complex assembly

[Term]
id: GO:0051879
name: Hsp90 protein binding
namespace: molecular_function
def: "Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]
synonym: "Hsp90 binding" EXACT []
synonym: "Hsp90 class protein binding" EXACT []
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0051880
name: G-quadruplex DNA binding
namespace: molecular_function
def: "Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530]
synonym: "G quadruplex DNA binding" EXACT [GOC:mah]
synonym: "G quartet binding" BROAD [GOC:mah]
synonym: "G quartet DNA binding" EXACT [GOC:mah]
synonym: "G-DNA binding" EXACT []
synonym: "G-quartet binding" BROAD [GOC:mah]
synonym: "G-quartet DNA binding" EXACT [GOC:mah]
synonym: "quadruplex DNA binding" EXACT []
synonym: "tetraplex DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0051881
name: regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0051882
name: mitochondrial depolarization
namespace: biological_process
def: "The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level." [Wikipedia:Depolarization, Wikipedia:Mitochondrion]
synonym: "mitochondria depolarization" EXACT []
synonym: "mitochondrial depolarisation" EXACT []
synonym: "mitochondrial membrane depolarization" EXACT []
synonym: "mitochondrion depolarization" EXACT []
is_a: GO:0051881 ! regulation of mitochondrial membrane potential
is_a: GO:0051899 ! membrane depolarization

[Term]
id: GO:0051883
name: obsolete killing of cells in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0051884
name: regulation of timing of anagen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "regulation of anagen" RELATED []
is_a: GO:0048819 ! regulation of hair follicle maturation
relationship: regulates GO:0042640 ! anagen

[Term]
id: GO:0051885
name: positive regulation of timing of anagen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "activation of anagen" NARROW []
synonym: "positive regulation of anagen" RELATED []
synonym: "stimulation of anagen" NARROW []
synonym: "up regulation of anagen" RELATED []
synonym: "up-regulation of anagen" RELATED []
synonym: "upregulation of anagen" RELATED []
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051884 ! regulation of timing of anagen
relationship: positively_regulates GO:0042640 ! anagen

[Term]
id: GO:0051886
name: negative regulation of timing of anagen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "down regulation of anagen" RELATED []
synonym: "down-regulation of anagen" RELATED []
synonym: "downregulation of anagen" RELATED []
synonym: "inhibition of anagen" NARROW []
synonym: "negative regulation of anagen" RELATED []
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051884 ! regulation of timing of anagen
relationship: negatively_regulates GO:0042640 ! anagen

[Term]
id: GO:0051887
name: regulation of timing of exogen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "regulation of exogen" RELATED []
is_a: GO:0048819 ! regulation of hair follicle maturation
relationship: regulates GO:0042638 ! exogen

[Term]
id: GO:0051888
name: positive regulation of timing of exogen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "activation of exogen" NARROW []
synonym: "positive regulation of exogen" RELATED []
synonym: "stimulation of exogen" NARROW []
synonym: "up regulation of exogen" RELATED []
synonym: "up-regulation of exogen" RELATED []
synonym: "upregulation of exogen" RELATED []
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051887 ! regulation of timing of exogen
relationship: positively_regulates GO:0042638 ! exogen

[Term]
id: GO:0051889
name: negative regulation of timing of exogen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr]
synonym: "down regulation of exogen" RELATED []
synonym: "down-regulation of exogen" RELATED []
synonym: "downregulation of exogen" RELATED []
synonym: "inhibition of exogen" NARROW []
synonym: "negative regulation of exogen" RELATED []
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051887 ! regulation of timing of exogen
relationship: negatively_regulates GO:0042638 ! exogen

[Term]
id: GO:0051890
name: regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
is_a: GO:1905207 ! regulation of cardiocyte differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
relationship: regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051891
name: positive regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "activation of cardioblast differentiation" NARROW []
synonym: "stimulation of cardioblast differentiation" NARROW []
synonym: "up regulation of cardioblast differentiation" EXACT []
synonym: "up-regulation of cardioblast differentiation" EXACT []
synonym: "upregulation of cardioblast differentiation" EXACT []
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
relationship: positively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051892
name: negative regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "down regulation of cardioblast differentiation" EXACT []
synonym: "down-regulation of cardioblast differentiation" EXACT []
synonym: "downregulation of cardioblast differentiation" EXACT []
synonym: "inhibition of cardioblast differentiation" NARROW []
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
relationship: negatively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051893
name: regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "regulation of adhesion plaque assembly" RELATED []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0090109 ! regulation of cell-substrate junction assembly
relationship: regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051894
name: positive regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "activation of focal adhesion formation" NARROW []
synonym: "stimulation of focal adhesion formation" NARROW []
synonym: "up regulation of focal adhesion formation" EXACT []
synonym: "up-regulation of focal adhesion formation" EXACT []
synonym: "upregulation of focal adhesion formation" EXACT []
is_a: GO:0001954 ! positive regulation of cell-matrix adhesion
is_a: GO:0051893 ! regulation of focal adhesion assembly
is_a: GO:0150117 ! positive regulation of cell-substrate junction organization
is_a: GO:1901890 ! positive regulation of cell junction assembly
relationship: positively_regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051895
name: negative regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "down regulation of focal adhesion formation" EXACT []
synonym: "down-regulation of focal adhesion formation" EXACT []
synonym: "downregulation of focal adhesion formation" EXACT []
synonym: "inhibition of focal adhesion formation" NARROW []
is_a: GO:0001953 ! negative regulation of cell-matrix adhesion
is_a: GO:0051893 ! regulation of focal adhesion assembly
is_a: GO:0150118 ! negative regulation of cell-substrate junction organization
is_a: GO:1901889 ! negative regulation of cell junction assembly
relationship: negatively_regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051896
name: regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]
synonym: "regulation of AKT signaling cascade" RELATED []
synonym: "regulation of AKT signalling cascade" RELATED []
synonym: "regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" EXACT []
synonym: "regulation of PI3K-PKB/Akt pathway" EXACT []
synonym: "regulation of PI3K/Akt signal transduction" EXACT []
synonym: "regulation of PI3K/PKB signal transduction" EXACT []
synonym: "regulation of PKB signaling cascade" RELATED []
synonym: "regulation of PKB signalling cascade" RELATED []
synonym: "regulation of protein kinase B signaling" RELATED []
synonym: "regulation of protein kinase B signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of protein kinase B signalling cascade" RELATED []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0043491 ! phosphatidylinositol 3-kinase/protein kinase B signal transduction

[Term]
id: GO:0051897
name: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]
synonym: "activation of protein kinase B signaling cascade" NARROW []
synonym: "positive regulation of AKT signaling cascade" RELATED []
synonym: "positive regulation of AKT signalling cascade" RELATED []
synonym: "positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" EXACT []
synonym: "positive regulation of PI3K-PKB/Akt pathway" EXACT []
synonym: "positive regulation of PI3K/Akt signal transduction" EXACT []
synonym: "positive regulation of PI3K/PKB signal transduction" EXACT []
synonym: "positive regulation of PKB signaling cascade" RELATED []
synonym: "positive regulation of PKB signalling cascade" RELATED []
synonym: "positive regulation of protein kinase B signaling" RELATED []
synonym: "positive regulation of protein kinase B signaling cascade" RELATED []
synonym: "positive regulation of protein kinase B signalling cascade" RELATED []
synonym: "stimulation of protein kinase B signaling cascade" NARROW []
synonym: "up regulation of protein kinase B signaling cascade" RELATED []
synonym: "up-regulation of protein kinase B signaling cascade" RELATED []
synonym: "upregulation of protein kinase B signaling cascade" RELATED []
is_a: GO:0051896 ! regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0043491 ! phosphatidylinositol 3-kinase/protein kinase B signal transduction

[Term]
id: GO:0051898
name: negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]
synonym: "down regulation of protein kinase B signaling cascade" RELATED []
synonym: "down-regulation of protein kinase B signaling cascade" RELATED []
synonym: "downregulation of protein kinase B signaling cascade" RELATED []
synonym: "inhibition of protein kinase B signaling cascade" NARROW []
synonym: "negative regulation of AKT signaling cascade" RELATED []
synonym: "negative regulation of AKT signalling cascade" RELATED []
synonym: "negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" EXACT []
synonym: "negative regulation of PI3K-PKB/Akt pathway" EXACT []
synonym: "negative regulation of PI3K/Akt signal transduction" EXACT []
synonym: "negative regulation of PI3K/PKB signal transduction" EXACT []
synonym: "negative regulation of PKB signaling cascade" RELATED []
synonym: "negative regulation of PKB signalling cascade" RELATED []
synonym: "negative regulation of protein kinase B signaling" RELATED []
synonym: "negative regulation of protein kinase B signaling cascade" RELATED []
synonym: "negative regulation of protein kinase B signalling cascade" RELATED []
is_a: GO:0051896 ! regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0043491 ! phosphatidylinositol 3-kinase/protein kinase B signal transduction

[Term]
id: GO:0051899
name: membrane depolarization
namespace: biological_process
def: "The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dh, Wikipedia:Depolarization]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0051900
name: regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0051881 ! regulation of mitochondrial membrane potential
relationship: regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051901
name: positive regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
synonym: "activation of mitochondrial depolarization" NARROW []
synonym: "stimulation of mitochondrial depolarization" NARROW []
synonym: "up regulation of mitochondrial depolarization" EXACT []
synonym: "up-regulation of mitochondrial depolarization" EXACT []
synonym: "upregulation of mitochondrial depolarization" EXACT []
is_a: GO:0051900 ! regulation of mitochondrial depolarization
is_a: GO:1904181 ! positive regulation of membrane depolarization
relationship: positively_regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051902
name: negative regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
synonym: "down regulation of mitochondrial depolarization" EXACT []
synonym: "down-regulation of mitochondrial depolarization" EXACT []
synonym: "downregulation of mitochondrial depolarization" EXACT []
synonym: "inhibition of mitochondrial depolarization" NARROW []
is_a: GO:0051900 ! regulation of mitochondrial depolarization
is_a: GO:1904180 ! negative regulation of membrane depolarization
relationship: negatively_regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051903
name: S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284]
synonym: "ADH3 activity" NARROW [EC:1.1.1.284]
synonym: "chi-ADH activity" NARROW [EC:1.1.1.284]
synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "FDH activity" RELATED [EC:1.1.1.284]
synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "GD-FALDH activity" RELATED [EC:1.1.1.284]
synonym: "glutathione-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "GS-FDH activity" RELATED [EC:1.1.1.284]
synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "NAD-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "NAD-linked formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.284]
xref: EC:1.1.1.284
xref: KEGG_REACTION:R06983
xref: KEGG_REACTION:R07140
xref: MetaCyc:RXN-2962
xref: Reactome:R-HSA-5692237 "ADH5 oxidises S-HMGSH to S-FGSH"
xref: UM-BBD_reactionID:r1146
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0051904
name: pigment granule transport
namespace: biological_process
def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "pigment granule translocation" EXACT []
is_a: GO:0006810 ! transport
is_a: GO:0051875 ! pigment granule localization
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051905
name: establishment of pigment granule localization
namespace: biological_process
def: "The directed movement of a pigment granule to a specific location." [GOC:ai]
synonym: "establishment of pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0051875 ! pigment granule localization

[Term]
id: GO:0051906
name: maintenance of pigment granule location
namespace: biological_process
def: "Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of pigment granule localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051655 ! maintenance of vesicle location
relationship: part_of GO:0051875 ! pigment granule localization

[Term]
id: GO:0051907
name: S-(hydroxymethyl)glutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione." [EC:4.4.1.22, RHEA:22488]
synonym: "Gfa" RELATED [EC:4.4.1.22]
synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT []
synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" RELATED [EC:4.4.1.22]
synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" RELATED [EC:4.4.1.22]
xref: EC:4.4.1.22
xref: KEGG_REACTION:R06982
xref: MetaCyc:RXN-2961
xref: RHEA:22488
xref: UM-BBD_reactionID:r1145
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0051908
name: double-stranded DNA 5'-3' DNA exonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai]
synonym: "double-stranded DNA 5'-3' exodeoxyribonuclease activity" EXACT []
synonym: "double-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED []
xref: EC:3.1.11.3
is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity
is_a: GO:0035312 ! 5'-3' DNA exonuclease activity

[Term]
id: GO:0051909
name: obsolete acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as acetylenecarboxylate hydratase activity, producing 3-oxopropanoate ; GO:0050079.
synonym: "3-hydroxypropenoate dehydratase activity" EXACT []
synonym: "acetylenecarboxylate hydratase activity" BROAD []
synonym: "acetylenemonocarboxylate hydratase activity" BROAD []
synonym: "alkynoate hydratase activity" BROAD []
is_obsolete: true
replaced_by: GO:0050079

[Term]
id: GO:0051911
name: Methanosarcina-phenazine hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3]
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED []
synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" RELATED [EC:1.12.98.3]
synonym: "methanophenazine hydrogenase activity" EXACT []
synonym: "methylviologen-reducing hydrogenase activity" EXACT []
xref: EC:1.12.98.3
xref: MetaCyc:RXN-7733
xref: RHEA:24436
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0051912
name: CoB--CoM heterodisulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [RHEA:18085]
synonym: "CoB-CoM heterodisulfide reductase activity" EXACT []
synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT []
synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" RELATED [EC:1.8.98.1]
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED []
synonym: "heterodisulfide reductase activity" BROAD []
synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1]
xref: EC:1.8.98.1
xref: MetaCyc:1.8.98.1-RXN
xref: RHEA:18085
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0051913
name: regulation of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "regulation of synaptic plasticity by drug" NARROW []
is_a: GO:0048167 ! regulation of synaptic plasticity
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0051914
name: positive regulation of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "activation of synaptic plasticity by chemical substance" NARROW []
synonym: "positive regulation of synaptic plasticity by drug" NARROW []
synonym: "stimulation of synaptic plasticity by chemical substance" NARROW []
synonym: "up regulation of synaptic plasticity by chemical substance" EXACT []
synonym: "up-regulation of synaptic plasticity by chemical substance" EXACT []
synonym: "upregulation of synaptic plasticity by chemical substance" EXACT []
is_a: GO:0031915 ! positive regulation of synaptic plasticity
is_a: GO:0051913 ! regulation of synaptic plasticity by chemical substance

[Term]
id: GO:0051915
name: induction of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "activation of synaptic plasticity by chemical substance" EXACT []
synonym: "activation of synaptic plasticity by drug" NARROW []
synonym: "induction of synaptic plasticity by drug" NARROW []
is_a: GO:0051914 ! positive regulation of synaptic plasticity by chemical substance

[Term]
id: GO:0051916
name: granulocyte colony-stimulating factor binding
namespace: molecular_function
def: "Binding to granulocyte colony-stimulating factor, G-CSF." [GOC:ai]
synonym: "G-CSF binding" EXACT []
synonym: "granulocyte colony stimulating factor binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0051917
name: regulation of fibrinolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
is_a: GO:0030193 ! regulation of blood coagulation
relationship: regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051918
name: negative regulation of fibrinolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
synonym: "down regulation of fibrinolysis" EXACT []
synonym: "down-regulation of fibrinolysis" EXACT []
synonym: "downregulation of fibrinolysis" EXACT []
synonym: "inhibition of fibrinolysis" NARROW []
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051917 ! regulation of fibrinolysis
relationship: negatively_regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051919
name: positive regulation of fibrinolysis
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
synonym: "activation of fibrinolysis" NARROW []
synonym: "stimulation of fibrinolysis" NARROW []
synonym: "up regulation of fibrinolysis" EXACT []
synonym: "up-regulation of fibrinolysis" EXACT []
synonym: "upregulation of fibrinolysis" EXACT []
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051917 ! regulation of fibrinolysis
relationship: positively_regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051920
name: peroxiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]
comment: Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism.
synonym: "PRDX activity" EXACT []
synonym: "Prx activity" EXACT []
xref: Reactome:R-HSA-1222431 "Peroxynitrite is reduced to nitrite by AhpC"
xref: Reactome:R-HSA-1222755 "Peroxynitrite is reduced to nitrite by Tpx"
xref: Reactome:R-HSA-1500804 "Peroxynitrite is reduced by AhpE"
xref: RHEA:10008
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0051921
name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H+ + 4 phosphate." [EC:6.3.5.10, RHEA:23256]
synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT []
synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT []
synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.10]
synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT []
synonym: "CobQ activity" BROAD []
synonym: "cobyric acid synthase activity" RELATED []
xref: EC:6.3.5.10
xref: KEGG_REACTION:R05225
xref: MetaCyc:R345-RXN
xref: RHEA:23256
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0051922
name: cholesterol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+." [PMID:11416019, PMID:12145317, PMID:12730293, RHEA:52368]
xref: RHEA:52368
is_a: GO:0004027 ! alcohol sulfotransferase activity

[Term]
id: GO:0051923
name: sulfation
namespace: biological_process
def: "The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]
synonym: "phase II metabolism" BROAD [PMID:20056724]
synonym: "sulfonation" EXACT []
synonym: "sulfur addition" EXACT []
synonym: "sulphation" EXACT []
synonym: "sulphur addition" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051924
name: regulation of calcium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "regulation of calcium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051925
name: obsolete regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT []
synonym: "regulation of calcium transport via voltage-gated calcium channel" EXACT []
is_obsolete: true
consider: GO:0005245

[Term]
id: GO:0051926
name: negative regulation of calcium ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of calcium ion transport" EXACT []
synonym: "down-regulation of calcium ion transport" EXACT []
synonym: "downregulation of calcium ion transport" EXACT []
synonym: "inhibition of calcium ion transport" NARROW []
synonym: "negative regulation of calcium transport" EXACT []
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: negatively_regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051927
name: obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "down regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "down-regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "downregulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "inhibition of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "negative regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT []
synonym: "negative regulation of calcium transport via voltage gated calcium channel" RELATED []
is_obsolete: true
consider: GO:0005245

[Term]
id: GO:0051928
name: positive regulation of calcium ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of calcium ion transport" NARROW []
synonym: "positive regulation of calcium transport" EXACT []
synonym: "stimulation of calcium ion transport" NARROW []
synonym: "up regulation of calcium ion transport" EXACT []
synonym: "up-regulation of calcium ion transport" EXACT []
synonym: "upregulation of calcium ion transport" EXACT []
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: positively_regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051929
name: obsolete positive regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels." [GOC:ai]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "activation of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "positive regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT []
synonym: "positive regulation of calcium transport via voltage gated calcium channel" EXACT []
synonym: "stimulation of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "up regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "up-regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "upregulation of calcium ion transport via voltage gated calcium channel" EXACT []
is_obsolete: true
consider: GO:0005245

[Term]
id: GO:0051930
name: regulation of sensory perception of pain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0051931 ! regulation of sensory perception
relationship: regulates GO:0019233 ! sensory perception of pain

[Term]
id: GO:0051931
name: regulation of sensory perception
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0031644 ! regulation of nervous system process
relationship: regulates GO:0007600 ! sensory perception

[Term]
id: GO:0051932
name: synaptic transmission, GABAergic
namespace: biological_process
def: "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, ISBN:0126603030]
synonym: "GABAergic synaptic transmission" EXACT []
synonym: "synaptic transmission, GABA mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0051933
name: amino acid neurotransmitter reuptake
namespace: biological_process
def: "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "amino acid neurotransmitter import into glial cell" NARROW []
synonym: "amino acid neurotransmitter import into neuron" NARROW []
synonym: "amino acid neurotransmitter recycling" BROAD []
synonym: "amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0098810 ! neurotransmitter reuptake

[Term]
id: GO:0051934
name: catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "catecholamine neurotransmitter import into glial cell" NARROW []
synonym: "catecholamine neurotransmitter import into neuron" NARROW []
synonym: "catecholamine neurotransmitter recycling" BROAD []
synonym: "catecholamine neurotransmitter reuptake" EXACT []
synonym: "catecholamine reuptake during transmission of nerve impulse" RELATED []
synonym: "catecholamine uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0090493 ! catecholamine uptake
is_a: GO:0098810 ! neurotransmitter reuptake

[Term]
id: GO:0051935
name: glutamate reuptake
namespace: biological_process
def: "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387, Wikipedia:Glutamate_transporter]
synonym: "glutamate import into glial cell" NARROW []
synonym: "glutamate import into neuron" NARROW []
synonym: "glutamate recycling" BROAD []
synonym: "glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "L-glutamate reuptake" EXACT []
synonym: "L-glutamate uptake during transmission of nerve impulse" RELATED []
synonym: "L-glutamate uptake involved in synaptic transmission" EXACT []
is_a: GO:0051933 ! amino acid neurotransmitter reuptake
is_a: GO:0098712 ! L-glutamate import across plasma membrane

[Term]
id: GO:0051936
name: gamma-aminobutyric acid reuptake
namespace: biological_process
def: "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "GABA import into glial cell" NARROW []
synonym: "GABA import into neuron" NARROW []
synonym: "GABA recycling" BROAD []
synonym: "GABA reuptake" EXACT []
synonym: "gamma-aminobutyric acid import into glial cell" NARROW []
synonym: "gamma-aminobutyric acid import into neuron" NARROW []
synonym: "gamma-aminobutyric acid recycling" BROAD []
synonym: "gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "gamma-aminobutyric acid uptake involved in synaptic transmission" EXACT []
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0051933 ! amino acid neurotransmitter reuptake

[Term]
id: GO:0051937
name: catecholamine transport
namespace: biological_process
def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732]
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0051938
name: L-glutamate import
namespace: biological_process
def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0051939
name: gamma-aminobutyric acid import
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai]
synonym: "4-aminobutyrate import" EXACT []
synonym: "GABA import" EXACT []
synonym: "gamma-aminobutyrate import" EXACT []
synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015812 ! gamma-aminobutyric acid transport

[Term]
id: GO:0051940
name: regulation of catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "regulation of catecholamine neurotransmitter uptake" EXACT []
synonym: "regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission

[Term]
id: GO:0051941
name: regulation of amino acid uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "regulation of amino acid neurotransmitter uptake" EXACT []
synonym: "regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0051933 ! amino acid neurotransmitter reuptake

[Term]
id: GO:0051942
name: negative regulation of amino acid uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "down-regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "downregulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "inhibition of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "negative regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "negative regulation of amino acid neurotransmitter uptake" EXACT []
synonym: "negative regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051956 ! negative regulation of amino acid transport
relationship: negatively_regulates GO:0051933 ! amino acid neurotransmitter reuptake

[Term]
id: GO:0051943
name: positive regulation of amino acid uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "activation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "positive regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "positive regulation of amino acid neurotransmitter uptake" EXACT []
synonym: "stimulation of amino acid uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "up-regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "upregulation of amino acid uptake during transmission of nerve impulse" RELATED []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051957 ! positive regulation of amino acid transport
relationship: positively_regulates GO:0051933 ! amino acid neurotransmitter reuptake

[Term]
id: GO:0051944
name: positive regulation of catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "positive regulation of catecholamine neurotransmitter uptake" EXACT []
synonym: "positive regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb]
synonym: "stimulation of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of catecholamine uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission

[Term]
id: GO:0051945
name: negative regulation of catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "negative regulation of catecholamine neurotransmitter uptake" EXACT []
synonym: "negative regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission

[Term]
id: GO:0051946
name: regulation of glutamate uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "regulation of glutamate reuptake" EXACT []
synonym: "regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
synonym: "regulation of L-glutamate reuptake" EXACT []
synonym: "regulation of L-glutamate uptake during transmission of nerve impulse" EXACT []
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
relationship: regulates GO:0051935 ! glutamate reuptake

[Term]
id: GO:0051947
name: regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "regulation of GABA reuptake" EXACT []
synonym: "regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "regulation of gamma-aminobutyric acid reuptake" EXACT []
synonym: "regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
relationship: regulates GO:0051936 ! gamma-aminobutyric acid reuptake

[Term]
id: GO:0051948
name: negative regulation of glutamate uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of glutamate reuptake" EXACT []
synonym: "negative regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of glutamate uptake involved in conduction of nerve impulse" RELATED [GOC:dph]
is_a: GO:0002037 ! negative regulation of L-glutamate import across plasma membrane
is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse
relationship: negatively_regulates GO:0051935 ! glutamate reuptake

[Term]
id: GO:0051949
name: negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "negative regulation of GABA reuptake" EXACT []
synonym: "negative regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "negative regulation of gamma-aminobutyric acid reuptake" EXACT []
synonym: "negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
relationship: negatively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake

[Term]
id: GO:0051950
name: positive regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "positive regulation of GABA reuptake" EXACT []
synonym: "positive regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "positive regulation of gamma-aminobutyric acid reuptake" EXACT []
synonym: "positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
relationship: positively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake

[Term]
id: GO:0051951
name: positive regulation of glutamate uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "activation of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of glutamate reuptake" EXACT []
synonym: "positive regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of glutamate uptake during transmission of nerve impulse" EXACT []
is_a: GO:0002038 ! positive regulation of L-glutamate import across plasma membrane
is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse
relationship: positively_regulates GO:0051935 ! glutamate reuptake

[Term]
id: GO:0051952
name: regulation of amine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015837 ! amine transport

[Term]
id: GO:0051953
name: negative regulation of amine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amine transport" EXACT []
synonym: "down-regulation of amine transport" EXACT []
synonym: "downregulation of amine transport" EXACT []
synonym: "inhibition of amine transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051952 ! regulation of amine transport
relationship: negatively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051954
name: positive regulation of amine transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amine transport" NARROW []
synonym: "stimulation of amine transport" NARROW []
synonym: "up regulation of amine transport" EXACT []
synonym: "up-regulation of amine transport" EXACT []
synonym: "upregulation of amine transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051952 ! regulation of amine transport
relationship: positively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051955
name: regulation of amino acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051956
name: negative regulation of amino acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amino acid transport" EXACT []
synonym: "down-regulation of amino acid transport" EXACT []
synonym: "downregulation of amino acid transport" EXACT []
synonym: "inhibition of amino acid transport" NARROW []
synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah]
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: negatively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051957
name: positive regulation of amino acid transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amino acid transport" NARROW []
synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah]
synonym: "stimulation of amino acid transport" NARROW []
synonym: "up regulation of amino acid transport" EXACT []
synonym: "up-regulation of amino acid transport" EXACT []
synonym: "upregulation of amino acid transport" EXACT []
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: positively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051958
name: methotrexate transport
namespace: biological_process
def: "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0051959
name: dynein light intermediate chain binding
namespace: molecular_function
def: "Binding to a light intermediate chain of the dynein complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051960
name: regulation of nervous system development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051961
name: negative regulation of nervous system development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "down regulation of nervous system development" EXACT []
synonym: "down-regulation of nervous system development" EXACT []
synonym: "downregulation of nervous system development" EXACT []
synonym: "inhibition of nervous system development" NARROW []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
relationship: negatively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051962
name: positive regulation of nervous system development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "activation of nervous system development" NARROW []
synonym: "stimulation of nervous system development" NARROW []
synonym: "up regulation of nervous system development" EXACT []
synonym: "up-regulation of nervous system development" EXACT []
synonym: "upregulation of nervous system development" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
relationship: positively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051963
name: regulation of synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
subset: goslim_synapse
synonym: "regulation of synapse biogenesis" EXACT []
synonym: "regulation of synaptogenesis" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:1901888 ! regulation of cell junction assembly
relationship: regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051964
name: negative regulation of synapse assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "down regulation of synapse assembly" EXACT []
synonym: "down-regulation of synapse assembly" EXACT []
synonym: "downregulation of synapse assembly" EXACT []
synonym: "inhibition of synapse assembly" NARROW []
synonym: "negative regulation of synapse biogenesis" EXACT []
synonym: "negative regulation of synaptogenesis" EXACT []
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:1905809 ! negative regulation of synapse organization
relationship: negatively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051965
name: positive regulation of synapse assembly
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "activation of synapse assembly" NARROW []
synonym: "positive regulation of synapse biogenesis" EXACT []
synonym: "positive regulation of synaptogenesis" EXACT []
synonym: "stimulation of synapse assembly" NARROW []
synonym: "up regulation of synapse assembly" EXACT []
synonym: "up-regulation of synapse assembly" EXACT []
synonym: "upregulation of synapse assembly" EXACT []
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1901890 ! positive regulation of cell junction assembly
relationship: positively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051966
name: regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051967
name: negative regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "down regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "downregulation of synaptic transmission, glutamatergic" EXACT []
synonym: "inhibition of synaptic transmission, glutamatergic" NARROW []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
relationship: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051968
name: positive regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "activation of synaptic transmission, glutamatergic" NARROW []
synonym: "stimulation of synaptic transmission, glutamatergic" NARROW []
synonym: "up regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "upregulation of synaptic transmission, glutamatergic" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
relationship: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051969
name: regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0031644 ! regulation of nervous system process
relationship: regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051970
name: negative regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "down regulation of transmission of nerve impulse" EXACT []
synonym: "down-regulation of transmission of nerve impulse" EXACT []
synonym: "downregulation of transmission of nerve impulse" EXACT []
synonym: "inhibition of transmission of nerve impulse" NARROW []
synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051971
name: positive regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "activation of transmission of nerve impulse" NARROW []
synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of transmission of nerve impulse" NARROW []
synonym: "up regulation of transmission of nerve impulse" EXACT []
synonym: "up-regulation of transmission of nerve impulse" EXACT []
synonym: "upregulation of transmission of nerve impulse" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
relationship: positively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051972
name: obsolete regulation of telomerase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [EC:2.-.-.-, GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "telomerase regulator" EXACT []
is_obsolete: true

[Term]
id: GO:0051973
name: obsolete positive regulation of telomerase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "activation of telomerase activity" NARROW []
synonym: "stimulation of telomerase activity" NARROW []
synonym: "telomerase activator" RELATED []
synonym: "up regulation of telomerase activity" EXACT []
synonym: "up-regulation of telomerase activity" EXACT []
synonym: "upregulation of telomerase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0051974
name: obsolete negative regulation of telomerase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "down regulation of telomerase activity" EXACT []
synonym: "down-regulation of telomerase activity" EXACT []
synonym: "downregulation of telomerase activity" EXACT []
synonym: "inhibition of telomerase activity" NARROW []
synonym: "telomerase inhibitor" RELATED []
is_obsolete: true

[Term]
id: GO:0051975
name: lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine." [MetaCyc:LYSINE-AMINOAD-PWY]
synonym: "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT []
synonym: "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT []
xref: MetaCyc:LYSINE-AMINOAD-PWY
is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:0051976
name: lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine." [MetaCyc:PWY-3081]
synonym: "lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT []
synonym: "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT []
xref: MetaCyc:PWY-3081
is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:0051977
name: lysophospholipid transport
namespace: biological_process
def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai]
is_a: GO:0015914 ! phospholipid transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0051978
name: lysophospholipid:sodium symporter activity
namespace: molecular_function
def: "Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai]
synonym: "lysophospholipid transporter activity" BROAD []
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0051979
name: alginic acid acetylation
namespace: biological_process
def: "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate." [GOC:mlg]
synonym: "alginate acetylation" EXACT []
is_a: GO:0042120 ! alginic acid metabolic process

[Term]
id: GO:0051980
name: iron-nicotianamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai, PMID:20625001]
synonym: "Fe-NA chelate transporter activity" EXACT []
is_a: GO:0015603 ! iron chelate transmembrane transporter activity

[Term]
id: GO:0051981
name: copper chelate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [PMID:26512647]
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0051982
name: copper-nicotianamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai]
synonym: "Cu-NA chelate transporter activity" EXACT []
is_a: GO:0051981 ! copper chelate transmembrane transporter activity

[Term]
id: GO:0051983
name: regulation of chromosome segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051984
name: positive regulation of chromosome segregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "activation of chromosome segregation" NARROW []
synonym: "stimulation of chromosome segregation" NARROW []
synonym: "up regulation of chromosome segregation" EXACT []
synonym: "up-regulation of chromosome segregation" EXACT []
synonym: "upregulation of chromosome segregation" EXACT []
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051985
name: negative regulation of chromosome segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "down regulation of chromosome segregation" EXACT []
synonym: "down-regulation of chromosome segregation" EXACT []
synonym: "downregulation of chromosome segregation" EXACT []
synonym: "inhibition of chromosome segregation" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051983 ! regulation of chromosome segregation
relationship: negatively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051986
name: negative regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "down regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "down-regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "downregulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "inhibition of attachment of spindle microtubules to kinetochore" NARROW []
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
relationship: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051987
name: positive regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "activation of attachment of spindle microtubules to kinetochore" NARROW []
synonym: "stimulation of attachment of spindle microtubules to kinetochore" NARROW []
synonym: "up regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "up-regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "upregulation of attachment of spindle microtubules to kinetochore" EXACT []
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
relationship: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051988
name: regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "regulation of kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051989
name: coproporphyrinogen dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.98.3]
synonym: "coproporphyrinogen III oxidase activity" RELATED [EC:1.3.98.3]
synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" RELATED [EC:1.3.98.3]
synonym: "HemN" RELATED [EC:1.3.98.3]
synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT []
synonym: "radical SAM enzyme activity" RELATED [EC:1.3.98.3]
xref: EC:1.3.98.3
xref: MetaCyc:HEMN-RXN
xref: RHEA:15425
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0051990
name: (R)-2-hydroxyglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [RHEA:38295]
synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT []
xref: EC:1.1.99.39
xref: MetaCyc:RXN-14932
xref: Reactome:R-HSA-880007 "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2"
xref: Reactome:R-HSA-880053 "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]"
xref: RHEA:38295
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0051991
name: UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H+ + UDP." [RHEA:31227]
xref: MetaCyc:NACGLCTRANS-RXN
xref: RHEA:31227
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0051992
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP." [RHEA:28386]
comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13.
subset: goslim_chembl
xref: MetaCyc:PHOSNACMURPENTATRANS-RXN
xref: RHEA:28386
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0051993
name: abscisic acid glucose ester beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose." [PMID:16990135]
synonym: "ABA-GE beta-glucosidase activity" EXACT []
xref: EC:3.2.1.175
xref: MetaCyc:RXN-11469
xref: RHEA:31347
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0051994
name: P-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0051995
name: Se-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule." [GOC:ai]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0051996
name: squalene synthase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 (2E,6E)-farnesyl diphosphate + H+ + NAD(P)H = 2 diphosphate + NAD(P)+ + squalene." [EC:2.5.1.21]
synonym: "farnesyl-diphosphate farnesyltransferase activity" NARROW [EC:2.5.1.21]
synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.21]
synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21]
synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21]
synonym: "squalene synthase activity" EXACT [EC:2.5.1.21]
synonym: "squalene synthetase activity" RELATED [EC:2.5.1.21]
xref: EC:2.5.1.21
xref: MetaCyc:RXN66-281
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0051997
name: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2." [MetaCyc:RXN-6201]
synonym: "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity" EXACT []
synonym: "OHCU decarboxylase activity" EXACT []
xref: EC:4.1.1.97
xref: KEGG_REACTION:R06604
xref: MetaCyc:RXN-6201
xref: RHEA:26301
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0051998
name: protein carboxyl O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to a carboxyl group on a protein." [GOC:ai]
synonym: "protein carboxyl methyltransferase activity" EXACT []
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0010340 ! carboxyl-O-methyltransferase activity

[Term]
id: GO:0051999
name: mannosyl-inositol phosphorylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai]
synonym: "mannose inositol phosphoceramide biosynthetic process" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) biosynthetic process" EXACT []
synonym: "mannosyl-inositol phosphorylceramide anabolism" EXACT []
synonym: "mannosyl-inositol phosphorylceramide biosynthesis" EXACT []
synonym: "mannosyl-inositol phosphorylceramide formation" EXACT []
synonym: "mannosyl-inositol phosphorylceramide synthesis" EXACT []
synonym: "MIPC biosynthetic process" EXACT []
is_a: GO:0006675 ! mannosyl-inositol phosphorylceramide metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0052001
name: adhesion to host cell via type IV pili
namespace: biological_process
def: "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml]
synonym: "type IV pili-dependent localized adherence to host" EXACT []
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0052002
name: obsolete metabolism by symbiont of substance in host
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052003
name: symbiont-mediated suppression of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
alt_id: GO:0052004
alt_id: GO:0052252
alt_id: GO:0052253
def: "A process in which a virus interferes with, inhibits or disrupts a host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "disruption of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "down regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "inhibition by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "negative modulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
synonym: "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "negative regulation of host SA-mediated defense response" EXACT []
synonym: "suppression by organism of host salicylic acid-mediated defense response" EXACT []
synonym: "suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "suppression of host SA mediated defense response" EXACT []
is_a: GO:0052081 ! symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway
relationship: negatively_regulates GO:0009627 ! systemic acquired resistance
relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway

[Term]
id: GO:0052005
name: symbiont-mediated suppression of host ethylene-mediated defense response
namespace: biological_process
alt_id: GO:0052070
alt_id: GO:0052254
alt_id: GO:0052268
def: "A process in which a symbiont inhibits or disrupts the normal execution of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "downregulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "inhibition by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD []
synonym: "negative regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "suppression by organism of host ethylene-mediated defense response" EXACT []
synonym: "suppression by symbiont of host ethylene-mediated defense response" EXACT []
is_a: GO:0044414 ! symbiont-mediated suppression of host defenses
is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response

[Term]
id: GO:0052006
name: obsolete catabolism by symbiont of substance in host
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of substance in host" EXACT []
is_obsolete: true

[Term]
id: GO:0052007
name: obsolete biosynthesis by symbiont of substance in host
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "biosynthesis by organism of substance in host" EXACT []
is_obsolete: true

[Term]
id: GO:0052008
name: symbiont-mediated disruption of host cellular anatomical structure
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of a host cellular anatomical structure. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: goslim_virus
synonym: "catabolism of host cellular component by organism" EXACT []
synonym: "catabolism of host structural constituent by organism" EXACT []
synonym: "cytopathogenic effect" RELATED []
synonym: "degradation of host cellular component by organism" EXACT []
synonym: "disassembly by organism of host cellular component" EXACT []
synonym: "disassembly by symbiont of host cellular component" RELATED []
synonym: "disruption by symbiont of host cellular component" EXACT []
synonym: "symbiont-mediated disruption of host cellular anatomical entity" EXACT []
synonym: "symbiont-mediated disruption of host cellular component" BROAD []
is_a: GO:0052111 ! symbiont-mediated disruption of host anatomical structure

[Term]
id: GO:0052009
name: symbiont-mediated disruption of host cell wall
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "disassembly by symbiont of host cell wall" EXACT []
synonym: "disruption by symbiont of host cell wall" EXACT []
is_a: GO:0044278 ! disruption of cell wall in another organism
is_a: GO:0098933 ! symbiont-mediated disruption of host cell envelope

[Term]
id: GO:0052010
name: obsolete catabolism by symbiont of host cell wall cellulose
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host cell wall cellulose" EXACT []
is_obsolete: true

[Term]
id: GO:0052011
name: obsolete catabolism by symbiont of host cell wall pectin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host cell wall pectin" EXACT []
is_obsolete: true

[Term]
id: GO:0052012
name: obsolete catabolism by symbiont of host cell wall chitin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host cell wall chitin" EXACT []
is_obsolete: true

[Term]
id: GO:0052013
name: obsolete catabolism by symbiont of host macromolecule
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host macromolecule" EXACT []
is_obsolete: true

[Term]
id: GO:0052014
name: obsolete catabolism by symbiont of host protein
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host protein" EXACT []
is_obsolete: true

[Term]
id: GO:0052015
name: obsolete catabolism by symbiont of host carbohydrate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host carbohydrate" EXACT []
is_obsolete: true

[Term]
id: GO:0052016
name: obsolete catabolism by symbiont of host glucan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host glucan" EXACT []
is_obsolete: true

[Term]
id: GO:0052017
name: obsolete catabolism by symbiont of host xylan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of host xylan" EXACT []
is_obsolete: true

[Term]
id: GO:0052018
name: obsolete modulation by symbiont of RNA levels in host
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a readout.
synonym: "modulation by symbiont of host RNA levels" EXACT []
is_obsolete: true
consider: GO:0052167

[Term]
id: GO:0052019
name: obsolete modulation by symbiont of host hormone or growth regulator levels
namespace: biological_process
alt_id: GO:0052186
def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction" BROAD []
is_obsolete: true

[Term]
id: GO:0052020
name: obsolete modification by symbiont of host cell wall
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it is not different from disruption by symbiont of host cell wall ; GO:0052009.
synonym: "metabolism of host cell wall by organism" EXACT []
is_obsolete: true
replaced_by: GO:0052009

[Term]
id: GO:0052021
name: obsolete modulation by symbiont of ethylene levels in host
namespace: biological_process
alt_id: GO:0052449
def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation by organism of ethylene levels in other organism involved in symbiotic interaction" BROAD []
is_obsolete: true

[Term]
id: GO:0052022
name: obsolete modulation by symbiont of jasmonic acid levels in host
namespace: biological_process
alt_id: GO:0052456
def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction" BROAD []
is_obsolete: true

[Term]
id: GO:0052023
name: obsolete modulation by symbiont of salicylic acid levels in host
namespace: biological_process
alt_id: GO:0052469
def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction" BROAD []
is_obsolete: true

[Term]
id: GO:0052024
name: obsolete positive regulation by symbiont of hormone or growth regulator levels in host
namespace: biological_process
alt_id: GO:0052513
def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by symbiont of hormone or growth regulator levels in host" NARROW []
synonym: "positive modulation of hormone or growth regulator levels in host" EXACT []
synonym: "positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction" BROAD []
synonym: "stimulation by symbiont of hormone or growth regulator levels in host" NARROW []
synonym: "up regulation by symbiont of hormone or growth regulator levels in host" EXACT []
synonym: "up-regulation by symbiont of hormone or growth regulator levels in host" EXACT []
synonym: "upregulation by symbiont of hormone or growth regulator levels in host" EXACT []
is_obsolete: true

[Term]
id: GO:0052025
name: symbiont-mediated perturbation of host cell endomembrane system
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host endomembrane system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "disruption by symbiont of host cell membrane" BROAD []
synonym: "modification by symbiont of host cell membrane" BROAD []
synonym: "symbiont-mediated disruption of host cell membrane" BROAD []
synonym: "symbiont-mediated perturbation of host cell membrane" BROAD []
is_a: GO:0141171 ! symbiont-mediated perturbation of host membrane

[Term]
id: GO:0052026
name: symbiont-mediated perturbation of host transcription
namespace: biological_process
def: "A process in which a symbiont alters or subverts transcription in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by symbiont of host transcription" EXACT []
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0052027
name: symbiont-mediated perturbation of host signal transduction pathway
namespace: biological_process
alt_id: GO:0052250
def: "A process in which a symbiont alters or subverts a signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by symbiont of host signal transduction" RELATED []
synonym: "modulation by symbiont of host signal transduction pathway" EXACT []
synonym: "modulation of host signal transduction by symbiont" EXACT []
synonym: "modulation of signal transduction in other organism involved in symbiotic interaction" BROAD []
synonym: "perturbation of host signal transduction pathway" EXACT []
synonym: "regulation by symbiont of host signal transduction pathway" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0052028
name: symbiont-mediated activation of host signal transduction pathway
namespace: biological_process
alt_id: GO:0044502
alt_id: GO:0052526
def: "A process in which a symbiont subverts a signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by symbiont of host signal transduction pathway" NARROW []
synonym: "induction by symbiont of host signal transduction pathway" EXACT []
synonym: "positive regulation by organism of signal transduction in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "positive regulation of signal transduction in other organism" BROAD []
synonym: "stimulation by symbiont of host signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "upregulation by symbiont of host signal transduction pathway" EXACT []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0052029
name: symbiont-mediated suppression of host signal transduction pathway
namespace: biological_process
alt_id: GO:0052493
def: "A process in which a symbiont interferes with, inhibits or disrupts a host signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "disruption by symbiont of host signal transduction pathway" EXACT []
synonym: "disruption of host signal transduction pathway" EXACT []
synonym: "down regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of host signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of host signal transduction pathway" NARROW []
synonym: "negative modulation by organism of host signal transduction pathway" EXACT []
synonym: "negative regulation by organism of signal transduction in other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "suppression by symbiont of host signal transduction pathway" EXACT []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0052031
name: symbiont-mediated perturbation of host defense response
namespace: biological_process
alt_id: GO:0052255
def: "A process in which a symbiont interferes with the ability of the host to mount a defense in response to its presence. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "mitigation by symbiont of host defense response" EXACT []
synonym: "modulation by organism of defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host defense response" EXACT []
synonym: "pathogenesis" RELATED []
synonym: "perturbation by symbiont of host defense response" EXACT []
is_a: GO:0044003 ! symbiont-mediated perturbation of host process

[Term]
id: GO:0052032
name: symbiont-mediated perturbation of host inflammatory response
namespace: biological_process
alt_id: GO:0052256
def: "A process in which a symbiont alters or subverts the normal execution of the  inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host inflammatory response" EXACT []
synonym: "perturbation by symbiont of host inflammatory response" EXACT []
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response

[Term]
id: GO:0052033
name: obsolete pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
namespace: biological_process
def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
comment: This term was obsoleted because it has been misused.
synonym: "general elicitor-dependent activation of host innate immunity" EXACT []
synonym: "general elicitor-dependent induction of host innate immunity" EXACT []
synonym: "MAMP dependent activation of host innate immunity" EXACT []
synonym: "MAMP dependent induction of host innate immunity" EXACT []
synonym: "PAMP dependent activation of host innate immunity" EXACT []
synonym: "PAMP dependent induction of host innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent activation by organism of host innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity" EXACT [GOC:pg]
synonym: "pattern-triggered immunity" RELATED [GOC:tb]
synonym: "PTI" RELATED [GOC:tb]
is_obsolete: true
consider: GO:0002221
consider: GO:0002752
consider: GO:0052034

[Term]
id: GO:0052034
name: effector-mediated suppression of host pattern-triggered immunity
namespace: biological_process
alt_id: GO:0052258
def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
synonym: "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED []
synonym: "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED []
synonym: "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED []
synonym: "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED []
synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response" RELATED []
synonym: "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" RELATED []
synonym: "suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response" BROAD []
synonym: "suppression of general elicitor induced host innate immunity" RELATED []
synonym: "suppression of general elicitor-induced host innate immunity" RELATED []
synonym: "suppression of MAMP induced host innate immunity" RELATED []
synonym: "suppression of MAMP-induced host innate immunity" RELATED []
synonym: "suppression of PAMP induced host innate immunity" RELATED []
synonym: "suppression of PAMP-induced host innate immunity" RELATED []
synonym: "suppression of pathogen-associated molecular pattern-induced host innate immunity" RELATED []
is_a: GO:0140403 ! effector-mediated suppression of host innate immune response

[Term]
id: GO:0052035
name: obsolete positive regulation by symbiont of host inflammatory response
namespace: biological_process
alt_id: GO:0052259
def: "OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was not clearly defined.
synonym: "activation by symbiont of host inflammatory response" NARROW []
synonym: "positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD []
synonym: "stimulation by symbiont of host inflammatory response" NARROW []
synonym: "up regulation by symbiont of host inflammatory response" EXACT []
synonym: "up-regulation by symbiont of host inflammatory response" EXACT []
synonym: "upregulation by symbiont of host inflammatory response" EXACT []
is_obsolete: true

[Term]
id: GO:0052036
name: symbiont-mediated suppression of host inflammatory response
namespace: biological_process
alt_id: GO:0052260
def: "A process in which a symbiont inhibits or disrupts the normal execution of  inflammatory response in the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of host inflammatory response" EXACT []
synonym: "down-regulation by symbiont of host inflammatory response" EXACT []
synonym: "downregulation by symbiont of host inflammatory response" EXACT []
synonym: "inhibition by symbiont of host inflammatory response" NARROW []
synonym: "negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of host inflammatory response" EXACT []
synonym: "suppression by symbiont of host inflammatory response" EXACT []
is_a: GO:0052032 ! symbiont-mediated perturbation of host inflammatory response

[Term]
id: GO:0052038
name: symbiont-mediated perturbation of host intracellular transport
namespace: biological_process
def: "A process in which a symbiont alters or subverts the directed movement of substances within the cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by symbiont of host intracellular transport" BROAD []
synonym: "modulation of host intracellular trafficking" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0052039
name: symbiont-mediated perturbation of host cytoskeleton
namespace: biological_process
alt_id: GO:0044054
def: "The process in which an organism effects a change that impairs the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "disruption by symbiont of host cytoskeleton" RELATED []
synonym: "modification by symbiont of host cytoskeleton" RELATED []
synonym: "perturbation by symbiont of host cytoskeleton" EXACT []
synonym: "rounding by symbiont of host cells" NARROW []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0052040
name: symbiont-mediated perturbation of host programmed cell death
namespace: biological_process
alt_id: GO:0052152
def: "A process in which a symbiont gene product alters or subverts host programmed cell death, leading to a change in the frequency, rate or extent of host programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators]
synonym: "modulation by symbiont of host non-apoptotic programmed cell death" NARROW []
synonym: "modulation by symbiont of host programmed cell death" EXACT []
synonym: "modulation of host PCD" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0052041
name: symbiont-mediated suppression of host programmed cell death
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal execution of host programmed cell death, leading to a decrease in the frequency, rate or extent of programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators]
synonym: "down regulation by symbiont of host programmed cell death" EXACT []
synonym: "down-regulation by symbiont of host programmed cell death" EXACT []
synonym: "downregulation by symbiont of host programmed cell death" EXACT []
synonym: "inhibition by symbiont of host programmed cell death" NARROW []
synonym: "inhibition of host programmed cell death" EXACT []
synonym: "negative regulation by symbiont of host programmed cell death" EXACT []
synonym: "suppression by symbiont of host PCD" EXACT []
synonym: "suppression by symbiont of host programmed cell death" EXACT []
is_a: GO:0052040 ! symbiont-mediated perturbation of host programmed cell death

[Term]
id: GO:0052042
name: symbiont-mediated activation of host programmed cell death
namespace: biological_process
alt_id: GO:0012504
alt_id: GO:0052044
alt_id: GO:0052045
alt_id: GO:0052153
alt_id: GO:0052397
alt_id: GO:0052400
def: "A process in which a symbiont gene product activates host programmed cell death, leading to an increase in the frequency, rate or extent of programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators]
synonym: "activation by organism of host programmed cell death" EXACT []
synonym: "activation by organism of non-apoptotic programmed cell death in other organism" NARROW []
synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "activation by symbiont of host programmed cell death" NARROW []
synonym: "enhancement of host programmed cell death" EXACT []
synonym: "enhancement of host programmed cell death by organism" EXACT []
synonym: "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "induction by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT []
synonym: "induction by symbiont of host programmed cell death" EXACT []
synonym: "induction of non-apoptotic programmed cell death by other organism" RELATED []
synonym: "pathogenesis" RELATED []
synonym: "positive regulation by symbiont of host non-apoptotic programmed cell death" NARROW []
synonym: "positive regulation by symbiont of host programmed cell death" EXACT []
synonym: "stimulation by symbiont of host programmed cell death" NARROW []
synonym: "upregulation by symbiont of host programmed cell death" EXACT []
is_a: GO:0052040 ! symbiont-mediated perturbation of host programmed cell death

[Term]
id: GO:0052043
name: obsolete modification by symbiont of host cellular component
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents the same concept as its child \ndisruption by symbiont of host cellular component ; GO:0052008.
is_obsolete: true
replaced_by: GO:0052008

[Term]
id: GO:0052046
name: obsolete modification by symbiont of host morphology or physiology via secreted substance
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "modification of host morphology or physiology via effector molecule" NARROW []
synonym: "modification of host morphology or physiology via ellicitor" NARROW []
is_obsolete: true

[Term]
id: GO:0052047
name: obsolete symbiotic process mediated by secreted substance
namespace: biological_process
def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it has been misused to annotate host proteins.
synonym: "interaction with other organism via secreted substance during symbiotic interaction" RELATED [GOC:dph]
synonym: "interaction with other organism via secreted substance involved in symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052048
name: obsolete interaction with host via secreted substance
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process.
synonym: "interaction with host via secreted substance during symbiotic interaction" RELATED [GOC:dph]
synonym: "interaction with host via secreted substance involved in symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052049
name: obsolete interaction with host via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0052050
name: obsolete interaction with host via substance secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0052051
name: obsolete interaction with host via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0052052
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0052053
name: obsolete negative regulation by symbiont of host catalytic activity
namespace: biological_process
alt_id: GO:0052056
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation by symbiont of host enzyme activity" EXACT []
synonym: "down-regulation by symbiont of host enzyme activity" EXACT []
synonym: "downregulation by symbiont of host enzyme activity" EXACT []
synonym: "inhibition by symbiont of host enzyme activity" NARROW []
synonym: "inhibition of host enzyme activity" EXACT []
synonym: "negative regulation by symbiont of host enzyme activity" EXACT []
synonym: "negative regulation by symbiont of host molecular function" BROAD []
is_obsolete: true

[Term]
id: GO:0052054
name: obsolete negative regulation by symbiont of host peptidase activity
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation by symbiont of host protease activity" NARROW []
synonym: "down-regulation by symbiont of host protease activity" NARROW []
synonym: "downregulation by symbiont of host protease activity" NARROW []
synonym: "inhibition by symbiont of host protease activity" NARROW []
synonym: "inhibition of host protease activity" NARROW []
synonym: "negative regulation by symbiont of host protease activity" NARROW [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0052055
name: obsolete modulation by symbiont of host molecular function
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modification by symbiont of host molecular function" EXACT []
synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0052057
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0052058
name: obsolete modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0052062
name: obsolete induction by symbiont of host phytoalexin production
namespace: biological_process
alt_id: GO:0052262
def: "OBSOLETE. The activation by a symbiont of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by organism of host phytoalexin production" EXACT []
synonym: "induction by organism of phytoalexin production in other organism involved in symbiotic interaction" BROAD []
is_obsolete: true

[Term]
id: GO:0052063
name: obsolete induction by symbiont of defense-related host nitric oxide production
namespace: biological_process
alt_id: GO:0052263
alt_id: GO:0052345
alt_id: GO:0052347
def: "OBSOLETE. The activation by a symbiont of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because this process does not exist.
synonym: "activation by organism of defense-related host nitric oxide production" EXACT []
synonym: "activation by organism of defense-related host NO production" EXACT []
synonym: "activation by symbiont of defense-related host nitric oxide production" RELATED []
synonym: "induction by organism of defense-related host NO production" EXACT []
synonym: "induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" RELATED []
synonym: "positive regulation by organism of defense-related host NO production" RELATED []
synonym: "positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of defense-related host nitric oxide production" RELATED []
synonym: "stimulation by symbiont of defense-related host nitric oxide production" RELATED []
synonym: "up regulation by symbiont of defense-related host nitric oxide production" RELATED []
synonym: "up-regulation by symbiont of defense-related host nitric oxide production" RELATED []
synonym: "upregulation by symbiont of defense-related host nitric oxide production" RELATED []
is_obsolete: true

[Term]
id: GO:0052064
name: obsolete symbiont-mediated activation of reactive oxygen species production in host cell
namespace: biological_process
def: "OBSOLETE. The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:30823485]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by symbiont of defense-related host metabolic burst" EXACT []
synonym: "activation by symbiont of defense-related host oxidative burst" EXACT []
synonym: "activation by symbiont of defense-related host reactive oxidative species production" EXACT []
synonym: "activation by symbiont of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "activation by symbiont of defense-related host reactive oxygen species production" EXACT []
synonym: "activation by symbiont of defense-related host respiratory burst" EXACT []
synonym: "activation by symbiont of defense-related host ROI production" EXACT []
synonym: "activation by symbiont of defense-related host ROS production" EXACT []
synonym: "induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD []
synonym: "induction by symbiont of defense-related host active oxygen species production" EXACT []
synonym: "induction by symbiont of defense-related host AOS production" EXACT []
synonym: "induction by symbiont of defense-related host metabolic burst" EXACT []
synonym: "induction by symbiont of defense-related host oxidative burst" EXACT []
synonym: "induction by symbiont of defense-related host reactive oxidative species production" EXACT []
synonym: "induction by symbiont of defense-related host reactive oxygen species production" RELATED []
synonym: "induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of defense-related host reactive oxygen species production" RELATED []
synonym: "stimulation by symbiont of defense-related host reactive oxygen species production" RELATED []
synonym: "up regulation by symbiont of defense-related host reactive oxygen species production" RELATED []
synonym: "up-regulation by symbiont of defense-related host reactive oxygen species production" RELATED []
synonym: "upregulation by symbiont of defense-related host reactive oxygen species production" RELATED []
is_obsolete: true

[Term]
id: GO:0052066
name: obsolete entry of symbiont into host cell by promotion of host phagocytosis
namespace: biological_process
def: "OBSOLETE. The invasion by a symbiont of a host organism cell by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was misused.
synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction" RELATED []
synonym: "entry of organism into host cell by promotion of host phagocytosis" EXACT []
synonym: "penetration of organism into host cell by promotion of host phagocytosis" EXACT [GOC:vw]
synonym: "penetration of symbiont into host cell by promotion of host phagocytosis" EXACT [GOC:vw]
is_obsolete: true

[Term]
id: GO:0052067
name: symbiont-mediated perturbation of host phagocytosis
namespace: biological_process
alt_id: GO:0052380
alt_id: GO:0052483
def: "A process in which in a symbiont interferes with or inhibits host phagocytosis by targeting phagocytic signaling or the cellular phagocytic machinery. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23084912, PMID:29114249]
synonym: "antiphagocytosis" RELATED []
synonym: "disruption of host phagocytosis" EXACT []
synonym: "inhibition by symbiont of entry into host cell via phagocytosis" NARROW []
synonym: "modulation by organism of entry into host via host phagocytosis" BROAD []
synonym: "modulation by symbiont of entry into host via phagocytosis" BROAD []
synonym: "phagocytosis avoidance" RELATED []
is_a: GO:0030682 ! symbiont-mediated perturbation of host defenses

[Term]
id: GO:0052072
name: obsolete induction by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
alt_id: GO:0052270
def: "OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052074
name: obsolete positive regulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
alt_id: GO:0052272
def: "OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "induction by organism of host SA-mediated defense response" NARROW []
synonym: "induction by organism of host salicylic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of host SA-mediated defense response" EXACT []
synonym: "positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "stimulation by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "upregulation by symbiont of host salicylic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052075
name: obsolete induction by symbiont of host jasmonic acid-mediated defense response
namespace: biological_process
alt_id: GO:0052273
def: "OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "induction by organism of host JA-mediated defense response" NARROW []
synonym: "induction by organism of host jasmonic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of host JA-mediated defense response" EXACT []
synonym: "positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "stimulation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "upregulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052076
name: obsolete induction by symbiont of host ethylene-mediated defense response
namespace: biological_process
alt_id: GO:0052071
alt_id: GO:0052269
alt_id: GO:0052274
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "activation by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD []
synonym: "positive regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "stimulation by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "upregulation by symbiont of host ethylene-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052078
name: symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway
namespace: biological_process
alt_id: GO:0052275
def: "A process in which a symbiont interferes with, inhibits or disrupts a PAMP signaling pathway in its host organism, initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18005697]
synonym: "disruption of host PAMP receptor signaling pathway" EXACT []
synonym: "disruption of host pathogen-associated molecular pattern receptor signaling pathway" EXACT []
synonym: "suppression of host pathogen-associated molecular pattern receptor signaling pathway" NARROW []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response

[Term]
id: GO:0052079
name: obsolete induction by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
namespace: biological_process
alt_id: GO:0052276
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because this process does not exist.
synonym: "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052080
name: symbiont-mediated perturbation of host MAPK cascade
namespace: biological_process
alt_id: GO:0052277
def: "A process in which a symbiont alters or subverts a MAP kinase-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" RELATED []
synonym: "modulation by symbiont of host innate immune response MAPK kinase signaling" NARROW []
synonym: "modulation of defense-related host MAPK-mediated signal transduction pathway by organism" NARROW []
synonym: "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" NARROW []
synonym: "perturbation by symbiont of host MAP kinase signal transduction pathway" EXACT []
synonym: "perturbation of host innate immune response MAPK kinase signaling" NARROW []
synonym: "perturbation of host MAP signal transduction pathway" EXACT []
synonym: "perturbation of host MAPK kinase signaling pathway" EXACT []
synonym: "perturbation of host MAPK signal transduction pathway" EXACT []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0052081
name: symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway
namespace: biological_process
alt_id: GO:0052445
def: "A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:35698792]
synonym: "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT []
synonym: "perturbation of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0052083
name: obsolete symbiont-mediated suppression of host cell-mediated immune response
namespace: biological_process
alt_id: GO:0052278
def: "OBSOLETE. A process by which a symbiont interferes with, inhibits or disrupts the normal execution of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was poorly defined and used inconsistently.
synonym: "down regulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "downregulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "inhibition by symbiont of host cell-mediated immune response" NARROW []
synonym: "negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "suppression by symbiont of host cell-mediated immune response" EXACT []
is_obsolete: true
consider: GO:0052085

[Term]
id: GO:0052084
name: modulation by symbiont of host ethylene-mediated defense response
namespace: biological_process
alt_id: GO:0052077
alt_id: GO:0052279
alt_id: GO:0052441
def: "Any process in which a symbiont modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD []
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0052085
name: symbiont-mediated suppression of host T-cell mediated immune response
namespace: biological_process
alt_id: GO:0052280
def: "A process by which a symbiont interferes with, inhibits or disrupts the normal execution of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "downregulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "inhibition by symbiont of host T-cell mediated immune response" NARROW []
synonym: "negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "suppression by symbiont of host T-cell mediated immune response" EXACT []
synonym: "suppression of host T-cell mediated immune response" EXACT []
is_a: GO:0039504 ! symbiont-mediated suppression of host adaptive immune response
is_a: GO:0052156 ! symbiont-mediated perturbation of host T-cell mediated immune response

[Term]
id: GO:0052086
name: symbiont-mediated suppression of host B-cell mediated immune response
namespace: biological_process
alt_id: GO:0052281
def: "A process by which a symbiont interferes with, inhibits or disrupts the normal execution of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "downregulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "inhibition by symbiont of host B-cell mediated immune response" NARROW []
synonym: "negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "suppression by symbiont of host B-cell mediated immune response" EXACT []
synonym: "suppression of host B-cell mediated immune response" EXACT []
is_a: GO:0039504 ! symbiont-mediated suppression of host adaptive immune response

[Term]
id: GO:0052088
name: symbiont-mediated perturbation of host jasmonic acid signaling
namespace: biological_process
alt_id: GO:0052068
alt_id: GO:0052069
alt_id: GO:0052073
alt_id: GO:0052082
alt_id: GO:0052266
alt_id: GO:0052267
alt_id: GO:0052271
alt_id: GO:0052283
alt_id: GO:0052443
def: "A process in which a symbiont alters or subverts a jasmonic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:29222513, PMID:35698792]
synonym: "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "down regulation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "down-regulation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "downregulation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW []
synonym: "modulation by organism of host JA-mediated defense response" NARROW []
synonym: "modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW []
synonym: "modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW []
synonym: "negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW []
synonym: "negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "negative regulation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW []
synonym: "positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "suppression by organism of host JA-mediated defense response" EXACT []
synonym: "suppression by symbiont of host jasmonic acid-mediated defense response" RELATED []
synonym: "symbiont defense to host-produced jasmonic acid" EXACT []
synonym: "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response

[Term]
id: GO:0052089
name: obsolete modulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
alt_id: GO:0052284
def: "OBSOLETE. Any process in which a symbiont modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modulation by organism of host SA-mediated defense response" EXACT []
synonym: "modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD []
is_obsolete: true
replaced_by: GO:0052003

[Term]
id: GO:0052091
name: modulation of nutrient release by host
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by symbiont of nutrient release from host" EXACT []
is_a: GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052092
name: positive regulation of nutrient release by host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by symbiont of nutrient release from host" NARROW []
synonym: "positive regulation by symbiont of nutrient release from host" EXACT []
synonym: "promotion of nutrient release from host" EXACT []
synonym: "stimulation by symbiont of nutrient release from host" NARROW []
synonym: "up regulation by symbiont of nutrient release from host" EXACT []
synonym: "up-regulation by symbiont of nutrient release from host" EXACT []
synonym: "upregulation by symbiont of nutrient release from host" EXACT []
is_a: GO:0052091 ! modulation of nutrient release by host

[Term]
id: GO:0052093
name: formation of specialized structure for nutrient acquisition
namespace: biological_process
def: "The assembly of a symbiotic cellular or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "formation by organism of specialized structure for nutrient acquisition from host" EXACT []
synonym: "formation by symbiont of specialized structure for nutrient acquisition from host" EXACT []
synonym: "formation of specialized structure for nutrient acquisition from host" EXACT []
is_a: GO:0044111 ! formation of structure involved in a symbiotic process
relationship: part_of GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052094
name: formation of haustorium for nutrient acquisition
namespace: biological_process
def: "The assembly of a haustorium, a projection from a symbiotic cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "formation by organism of haustoria for nutrient acquisition from host" EXACT []
synonym: "formation by organism of haustorium for nutrient acquisition from host" EXACT []
synonym: "formation by symbiont of haustorium for nutrient acquisition from host" RELATED []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition

[Term]
id: GO:0052095
name: obsolete formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052096
name: formation of syncytium involving giant cell for nutrient acquisition
namespace: biological_process
def: "The assembly of a syncytium, a multi-nucleate and physiologically active aggregation of fused root cells induced by a symbiotic nematode in a plant host. The syncytium exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "formation by organism of syncytium involving giant cell for nutrient acquisition from host" EXACT []
synonym: "formation by symbiont of syncytium involving giant cell for nutrient acquisition from host" RELATED []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition

[Term]
id: GO:0052097
name: obsolete interspecies quorum sensing
namespace: biological_process
def: "OBSOLETE. The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0052098
name: formation by host of specialized structure for nutrient acquisition from symbiont
namespace: biological_process
def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051702 ! biological process involved in interaction with symbiont
relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont

[Term]
id: GO:0052100
name: obsolete intraspecies quorum sensing
namespace: biological_process
def: "OBSOLETE. The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0052102
name: obsolete positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway
namespace: biological_process
alt_id: GO:0052287
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW []
synonym: "positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation of defense-related host CDPK pathway by organism" EXACT []
synonym: "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
synonym: "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052103
name: symbiont-mediated activation of host induced systemic resistance
namespace: biological_process
alt_id: GO:0052288
alt_id: GO:0052532
alt_id: GO:0052533
def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:31516360]
synonym: "activation by organism of induced systemic resistance in host" EXACT []
synonym: "activation by organism of ISR in host" EXACT []
synonym: "activation by symbiont of induced systemic resistance in host" NARROW []
synonym: "induction by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD []
synonym: "induction by organism of ISR in host" EXACT []
synonym: "induction by symbiont of host induced systemic resistance" EXACT []
synonym: "induction by symbiont of induced systemic resistance in host" EXACT []
synonym: "induction of host induced systemic resistance" EXACT []
synonym: "positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of host induced systemic resistance" RELATED []
synonym: "positive regulation by symbiont of induced systemic resistance in host" RELATED []
synonym: "stimulation by symbiont of induced systemic resistance in host" NARROW []
synonym: "up regulation by symbiont of induced systemic resistance in host" RELATED []
synonym: "up-regulation by symbiont of induced systemic resistance in host" RELATED []
synonym: "upregulation by symbiont of induced systemic resistance in host" RELATED []
is_a: GO:0052159 ! symbiont-mediated perturbation of host induced systemic resistance

[Term]
id: GO:0052104
name: obsolete induction by symbiont of host systemic acquired resistance
namespace: biological_process
alt_id: GO:0052289
alt_id: GO:0052535
alt_id: GO:0052537
def: "OBSOLETE. Any process in which a symbiont activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by organism of SAR in host" EXACT []
synonym: "activation by organism of systemic acquired resistance in host" EXACT []
synonym: "induction by organism of SAR in host" EXACT []
synonym: "induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD []
synonym: "induction by symbiont of systemic acquired resistance in host" EXACT []
synonym: "positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of host systemic acquired resistance" RELATED []
synonym: "positive regulation by symbiont of systemic acquired resistance in host" RELATED []
synonym: "stimulation by symbiont of systemic acquired resistance in host" RELATED []
synonym: "up regulation by symbiont of systemic acquired resistance in host" RELATED []
synonym: "up-regulation by symbiont of systemic acquired resistance in host" RELATED []
synonym: "upregulation by symbiont of systemic acquired resistance in host" RELATED []
is_obsolete: true

[Term]
id: GO:0052105
name: obsolete induction by symbiont of defense-related host cell wall thickening
namespace: biological_process
alt_id: GO:0052290
alt_id: GO:0052538
alt_id: GO:0052539
def: "OBSOLETE. The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process.
synonym: "activation by organism of defense-related host cell wall thickening" EXACT []
synonym: "activation by organism of host defensive cell wall thickening" EXACT []
synonym: "activation by symbiont of defense-related host cell wall thickening" EXACT []
synonym: "induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD []
synonym: "induction by organism of host defensive cell wall thickening" EXACT []
synonym: "positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by organism of host defensive cell wall thickening" RELATED []
synonym: "positive regulation by symbiont of defense-related host cell wall thickening" RELATED []
synonym: "stimulation by symbiont of defense-related host cell wall thickening" RELATED []
synonym: "up regulation by symbiont of defense-related host cell wall thickening" RELATED []
synonym: "up-regulation by symbiont of defense-related host cell wall thickening" RELATED []
synonym: "upregulation by symbiont of defense-related host cell wall thickening" RELATED []
is_obsolete: true

[Term]
id: GO:0052106
name: obsolete quorum sensing involved in interaction with host
namespace: biological_process
def: "OBSOLETE. The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that this term was not clearly defined and usage was inconsistent.
synonym: "quorum sensing during interaction with host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052108
name: obsolete growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development of organism during interaction with host" EXACT []
synonym: "growth or development of organism in response to host" EXACT []
synonym: "growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true
consider: GO:0044111
consider: GO:0051701

[Term]
id: GO:0052109
name: obsolete induction by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
alt_id: GO:0052107
alt_id: GO:0052291
alt_id: GO:0052292
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process.
synonym: "activation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of defense-related host callose deposition" RELATED []
synonym: "positive regulation by symbiont of defense-related host cell wall callose deposition" RELATED []
synonym: "stimulation by symbiont of defense-related host cell wall callose deposition" RELATED []
synonym: "up regulation by symbiont of defense-related host cell wall callose deposition" RELATED []
synonym: "up-regulation by symbiont of defense-related host cell wall callose deposition" RELATED []
synonym: "upregulation by symbiont of defense-related host cell wall callose deposition" RELATED []
is_obsolete: true

[Term]
id: GO:0052110
name: obsolete occlusion by symbiont of host vascular system
namespace: biological_process
def: "OBSOLETE. The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was a grouping class for plant and animal structures, and occlusion of vessels in these different organisms is not mediated by shared pathways.
is_obsolete: true

[Term]
id: GO:0052111
name: symbiont-mediated disruption of host anatomical structure
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of an anatomical structure of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "cytopathogenic effect" RELATED []
synonym: "disruption by symbiont of host anatomical structure" EXACT []
synonym: "modification by symbiont of host anatomical structure" EXACT []
synonym: "modification by symbiont of host structure" RELATED []
is_a: GO:0141060 ! disruption of anatomical structure in another organism

[Term]
id: GO:0052112
name: symbiont-mediated occlusion of host xylem
namespace: biological_process
def: "The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:28871268]
synonym: "occlusion by symbiont of host xylem" EXACT []
is_a: GO:0052111 ! symbiont-mediated disruption of host anatomical structure

[Term]
id: GO:0052113
name: obsolete adaptation to host osmotic environment
namespace: biological_process
def: "OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because adaptation was not deemed to be a valid biological process.
synonym: "adaptation to host osmotic environment" EXACT []
synonym: "osmotic tolerance to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052114
name: obsolete adaptation to host pH environment
namespace: biological_process
def: "OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because adaptation was not deemed to be a valid biological process.
synonym: "adaptation to host pH environment" EXACT []
synonym: "pH tolerance to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052115
name: obsolete energy taxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "energy taxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052116
name: obsolete chemotaxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "chemotaxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052117
name: obsolete aerotaxis in host environment
namespace: biological_process
def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "aerotaxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052118
name: obsolete positive energy taxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive energy taxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052119
name: obsolete negative energy taxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative energy taxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052120
name: obsolete positive aerotaxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive aerotaxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052121
name: obsolete positive chemotaxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive chemotaxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052122
name: obsolete negative aerotaxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative aerotaxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052123
name: obsolete negative chemotaxis in host environment
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative chemotaxis in response to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052124
name: obsolete energy taxis within host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052125
name: obsolete energy taxis on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052127
name: obsolete movement on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0052128
name: positive energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0052129
name: negative energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0052130
name: negative aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06]
is_a: GO:0009454 ! aerotaxis
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0052129 ! negative energy taxis

[Term]
id: GO:0052131
name: positive aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06]
is_a: GO:0009454 ! aerotaxis
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0052128 ! positive energy taxis

[Term]
id: GO:0052132
name: obsolete positive aerotaxis on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052133
name: obsolete positive aerotaxis in host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive aerotaxis within host" EXACT []
is_obsolete: true

[Term]
id: GO:0052134
name: obsolete negative aerotaxis on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052135
name: obsolete negative aerotaxis in host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative aerotaxis within host" EXACT []
is_obsolete: true

[Term]
id: GO:0052136
name: obsolete negative chemotaxis on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052137
name: obsolete aerotaxis in host
namespace: biological_process
def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "aerotaxis within host" EXACT []
is_obsolete: true

[Term]
id: GO:0052138
name: obsolete aerotaxis on or near host
namespace: biological_process
def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052139
name: obsolete negative chemotaxis in host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative chemotaxis within host" EXACT []
is_obsolete: true

[Term]
id: GO:0052140
name: obsolete positive chemotaxis in host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive chemotaxis within host" EXACT []
is_obsolete: true

[Term]
id: GO:0052141
name: obsolete positive chemotaxis on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052142
name: obsolete chemotaxis within host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052143
name: obsolete chemotaxis on or near host involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "chemotaxis on or near host during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052144
name: obsolete negative energy taxis in host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative energy taxis within host" EXACT []
is_obsolete: true

[Term]
id: GO:0052145
name: obsolete negative energy taxis on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052146
name: obsolete positive energy taxis on or near host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
is_obsolete: true

[Term]
id: GO:0052147
name: obsolete positive energy taxis in host
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive energy taxis within host" EXACT []
is_obsolete: true

[Term]
id: GO:0052148
name: obsolete modulation by symbiont of host catalytic activity
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation by symbiont of host enzyme activity" EXACT [GOC:tb]
synonym: "modulation of catalytic activity of host by symbiont" EXACT []
synonym: "regulation by symbiont of host catalytic activity" EXACT []
synonym: "regulation of catalytic activity of host by symbiont" EXACT []
synonym: "regulation of host catalytic activity by symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052149
name: obsolete modulation by symbiont of host peptidase activity
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in host peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation by symbiont of host protease activity" NARROW [GOC:bf]
is_obsolete: true

[Term]
id: GO:0052150
name: symbiont-mediated perturbation of host apoptosis
namespace: biological_process
def: "A process in which a symbiont gene product affects host apoptosis, leading to a change in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'.
synonym: "modulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "modulation by symbiont of host apoptosis" NARROW []
synonym: "modulation by symbiont of host apoptotic process" EXACT []
synonym: "modulation by virus of host apoptosis" NARROW []
synonym: "regulation by virus of host apoptosis" NARROW []
xref: VZ:1518 "Apoptosis modulation"
is_a: GO:0051709 ! regulation of killing of cells of another organism
is_a: GO:0052040 ! symbiont-mediated perturbation of host programmed cell death

[Term]
id: GO:0052151
name: symbiont-mediated activation of host apoptosis
namespace: biological_process
alt_id: GO:0033669
alt_id: GO:0039651
alt_id: GO:0052030
alt_id: GO:0060139
def: "A process in which a symbiont initiates, promotes, or enhances the normal execution of host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11805081, PMID:18037263, PMID:19801898, PMID:29571981]
comment: Note that term is to be used to annotate gene products in the symbiont that play an active role in the activation of host apoptosis, usually by directly activating molecules involved either in apoptotic signaling or in apoptosis (such as caspases). Proteins and other molecules detected by the host that trigger host apoptosis should not be annotated to this term.
synonym: "activation by organism of host apoptosis" EXACT []
synonym: "activation by organism of host apoptotic programmed cell death" EXACT []
synonym: "activation by symbiont of host apoptosis" NARROW []
synonym: "induction by organism of host apoptotic programmed cell death" EXACT []
synonym: "induction by symbiont of host apoptosis" EXACT []
synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "positive regulation by symbiont of host apoptosis" NARROW []
synonym: "positive regulation by symbiont of host apoptotic process" EXACT []
synonym: "positive regulation by virus of host apoptosis" NARROW []
synonym: "stimulation by symbiont of host apoptosis" NARROW []
synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "up regulation by symbiont of host apoptosis" EXACT []
synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "up-regulation by symbiont of host apoptosis" EXACT []
synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "upregulation by symbiont of host apoptosis" EXACT []
is_a: GO:0001907 ! symbiont-mediated killing of host cell
is_a: GO:0052042 ! symbiont-mediated activation of host programmed cell death
is_a: GO:0052150 ! symbiont-mediated perturbation of host apoptosis

[Term]
id: GO:0052154
name: symbiont-mediated perturbation of host B-cell mediated immune response
namespace: biological_process
alt_id: GO:0052293
def: "A process in which a symbiont alters or subverts the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "perturbation of host B-cell mediated immune response" EXACT []
synonym: "regulation by organism of host B-cell mediated immune response" EXACT []
synonym: "symbiont-mediated perturbation of host humoral immune response" EXACT []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response

[Term]
id: GO:0052155
name: obsolete perturbation of host cell-mediated immune response
namespace: biological_process
alt_id: GO:0052294
def: "OBSOLETE. A process in which an organism effects a change that affects cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was poorly defined and used inconsistently.
synonym: "modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by organism of host cell-based immune response" EXACT []
synonym: "modulation by symbiont of host cell-mediated immune response" EXACT []
is_obsolete: true
consider: GO:0052085

[Term]
id: GO:0052156
name: symbiont-mediated perturbation of host T-cell mediated immune response
namespace: biological_process
alt_id: GO:0052295
def: "A process in which a symbiont alters or subverts the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "perturbation of host T-cell mediated immune response" EXACT []
synonym: "symbiont-mediated modulation of host cell-mediated immune response" EXACT []
synonym: "symbiont-mediated perturbation of host cell-mediated immune response" EXACT []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response

[Term]
id: GO:0052157
name: obsolete modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response
namespace: biological_process
alt_id: GO:0052296
def: "OBSOLETE. Any process that involves recognition of a microbe-associated molecular pattern, and by which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
comment: The reason for obsoletion is that this term has been misused.
synonym: "modulation by organism of microbe-associated molecular pattern-induced innate immune response in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" EXACT [GOC:pg]
synonym: "modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW []
is_obsolete: true

[Term]
id: GO:0052158
name: symbiont-mediated perturbation of host resistance gene-dependent defense response
namespace: biological_process
alt_id: GO:0052297
def: "Any process in which a symbiont modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of defense response in host by specific elicitors" EXACT []
synonym: "modulation by organism of host gene-for-gene resistance" EXACT []
synonym: "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
synonym: "modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host resistance gene-dependent defense response" EXACT []
is_a: GO:0030682 ! symbiont-mediated perturbation of host defenses
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response

[Term]
id: GO:0052159
name: symbiont-mediated perturbation of host induced systemic resistance
namespace: biological_process
alt_id: GO:0052298
def: "A process in which a symbiont alters or subverts the induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of induced systemic resistance in host" EXACT []
synonym: "perturbation of host induced systemic resistance" EXACT []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response

[Term]
id: GO:0052160
name: symbiont-mediated perturbation of host systemic acquired resistance
namespace: biological_process
alt_id: GO:0052299
def: "A process in which a symbiont alters or subverts systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host systemic acquired resistance" EXACT []
synonym: "modulation by symbiont of systemic acquired resistance in host" EXACT []
synonym: "perturbation of host systemic acquired resistance" EXACT []
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0052161
name: obsolete modulation by symbiont of defense-related host cell wall thickening
namespace: biological_process
alt_id: GO:0052300
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process.
synonym: "modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by organism of host defensive cell wall thickening" RELATED []
is_obsolete: true

[Term]
id: GO:0052162
name: obsolete symbiont-mediated perturbation of defense-related host calcium ion flux
namespace: biological_process
alt_id: GO:0052301
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction ; GO:0075135.
synonym: "modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by organism of defense-related host Ca2+ flux" EXACT []
synonym: "modulation by symbiont of defense-related host calcium ion flux" EXACT []
is_obsolete: true
replaced_by: GO:0075135

[Term]
id: GO:0052163
name: obsolete symbiont defense to host-produced nitric oxide
namespace: biological_process
alt_id: GO:0052060
alt_id: GO:0052302
alt_id: GO:0052376
alt_id: GO:0052551
alt_id: GO:0052565
def: "OBSOLETE. Any process in which a symbiont modulates the frequency, rate or extent of the production of nitric oxide as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because the response to nitric oxide does not depend on how nitric oxide is produced (by a host, or any other source).
synonym: "defense response to host innate immune response nitric oxide production" NARROW []
synonym: "evasion or tolerance by organism of host nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of host NO" EXACT []
synonym: "evasion or tolerance by organism of host-produced nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of host-produced NO" EXACT []
synonym: "evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction" BROAD []
synonym: "evasion or tolerance by symbiont of host-produced nitric oxide" EXACT []
synonym: "evasion or tolerance of nitric oxide produced by host in response to organism" EXACT []
synonym: "evasion or tolerance of NO produced by host in response to organism" EXACT []
synonym: "modulation by organism of defense-related host NO production" EXACT []
synonym: "modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of defense-related host nitric oxide production" RELATED []
synonym: "response to defense-related host nitric oxide production" RELATED []
synonym: "response to defense-related nitric oxide production by other organism involved in symbiotic interaction" BROAD []
is_obsolete: true
consider: GO:0070458

[Term]
id: GO:0052164
name: symbiont defense to host-produced reactive oxygen species
namespace: biological_process
alt_id: GO:0052059
alt_id: GO:0052303
alt_id: GO:0052385
alt_id: GO:0052550
alt_id: GO:0052567
def: "A process in which a symbiont alters or subverts either the host signal transduction pathways leading to the production of reactive oxygen species as part of the host innate immune response." [GOC:mtg_pamgo_17jul06]
synonym: "evasion by symbiont of cellular damage caused by host oxidative burst" NARROW []
synonym: "evasion or tolerance by organism of host-produced reactive oxygen species" EXACT []
synonym: "evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction" BROAD []
synonym: "evasion or tolerance by organism of reactive oxygen species produced during host defense response" EXACT []
synonym: "evasion or tolerance by symbiont of host-produced reactive oxygen species" EXACT []
synonym: "evasion or tolerance by symbiont of reactive oxygen species produced by other organism involved in symbiotic interaction" BROAD []
synonym: "evasion or tolerance of defense-related host metabolic burst" EXACT []
synonym: "evasion or tolerance of defense-related host oxidative burst" EXACT []
synonym: "evasion or tolerance of defense-related host respiratory burst" EXACT []
synonym: "evasion or tolerance of host-produced active oxygen species" EXACT []
synonym: "evasion or tolerance of host-produced AOS" EXACT []
synonym: "evasion or tolerance of host-produced reactive oxygen intermediates" EXACT []
synonym: "evasion or tolerance of host-produced ROIs" EXACT []
synonym: "evasion or tolerance of host-produced ROS" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by host" EXACT []
synonym: "modulation by organism of defense-related host active oxygen species production" EXACT []
synonym: "modulation by organism of defense-related host AOS production" EXACT []
synonym: "modulation by organism of defense-related host metabolic burst" EXACT []
synonym: "modulation by organism of defense-related host oxidative burst" EXACT []
synonym: "modulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "modulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "modulation by organism of defense-related host respiratory burst" EXACT []
synonym: "modulation by organism of defense-related host ROI production" EXACT []
synonym: "modulation by organism of defense-related host ROS production" EXACT []
synonym: "modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of defense-related host reactive oxygen species production" RELATED []
synonym: "response to defense-related host reactive oxygen species production" RELATED []
synonym: "response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction" BROAD []
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response

[Term]
id: GO:0052165
name: symbiont-mediated perturbation of host phytoalexin production
namespace: biological_process
alt_id: GO:0052061
alt_id: GO:0052304
alt_id: GO:0052378
alt_id: GO:0052549
alt_id: GO:0052566
def: "Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:6870275]
synonym: "evasion or tolerance by symbiont of host-produced phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by host in response to organism" EXACT []
synonym: "host phytoalexin detoxification" NARROW []
synonym: "modulation by organism of phytoalexin production in other organism involved in symbiotic interaction" NARROW []
synonym: "modulation by symbiont of host phytoalexin production" NARROW []
synonym: "phytoalexin detoxification" NARROW []
synonym: "response to host phytoalexin production" BROAD []
synonym: "response to phytoalexin production by other organism involved in symbiotic interaction" BROAD []
synonym: "symbiont defense to host-produced phytoalexin" EXACT []
xref: PMID:28805743
is_a: GO:0042783 ! symbiont-mediated evasion of host immune response

[Term]
id: GO:0052167
name: symbiont-mediated perturbation of host innate immune response
namespace: biological_process
alt_id: GO:0052306
def: "A process in which a symbiont alters or subverts the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of innate immune response in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host innate immunity" EXACT [GOC:pg]
synonym: "modulation of host innate immune response" EXACT []
synonym: "perturbation of host innate immune response" EXACT []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response

[Term]
id: GO:0052168
name: obsolete modulation by symbiont of defense-related host calcium-dependent protein kinase pathway
namespace: biological_process
alt_id: GO:0052307
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this pathway exists.
synonym: "modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by organism of defense-related host CDPK pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052169
name: obsolete pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response
namespace: biological_process
def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
comment: This term was obsoleted because it has been misused.
synonym: "pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity" EXACT [GOC:pg]
is_obsolete: true
consider: GO:0002221
consider: GO:0002752
consider: GO:0052034

[Term]
id: GO:0052170
name: symbiont-mediated suppression of host innate immune response
namespace: biological_process
alt_id: GO:0052309
def: "A process in which a symbiont inhibits or disrupts the normal execution of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of host innate immunity" EXACT []
synonym: "down-regulation by symbiont of host innate immunity" EXACT []
synonym: "downregulation by symbiont of host innate immunity" EXACT []
synonym: "inhibition by symbiont of host innate immunity" NARROW []
synonym: "negative regulation by symbiont of host innate immune response" EXACT []
synonym: "negative regulation by symbiont of host innate immunity" EXACT [GOC:pg]
synonym: "negative regulation of host innate immune response" EXACT []
synonym: "negative regulation of innate immune response in other organism" BROAD []
synonym: "suppression by symbiont of host innate immune response" EXACT []
synonym: "suppression of host innate immune response" EXACT []
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response
is_a: GO:0052562 ! symbiont-mediated suppression of host immune response

[Term]
id: GO:0052171
name: obsolete growth or development during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development during symbiotic interaction" EXACT []
is_obsolete: true
consider: GO:0044111

[Term]
id: GO:0052172
name: obsolete metabolism by symbiont of host cell wall cellulose
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052173
name: obsolete response to defenses of other organism
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of another organism." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "response to defenses of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "response to defenses of other organism involved in symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052174
name: obsolete metabolism by symbiont of host macromolecule
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052175
name: obsolete metabolism by symbiont of host carbohydrate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052176
name: obsolete metabolism by symbiont of host glucan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052177
name: obsolete metabolism by symbiont of host xylan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0052178
name: obsolete metabolism by symbiont of host cell wall chitin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052179
name: obsolete metabolism by symbiont of host cell wall pectin
namespace: biological_process
alt_id: GO:0052413
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction" NARROW []
is_obsolete: true

[Term]
id: GO:0052180
name: obsolete negative regulation of peptidase activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0052181
name: obsolete modulation by host of symbiont defense response
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response.
is_obsolete: true

[Term]
id: GO:0052182
name: obsolete modification by host of symbiont morphology or physiology via secreted substance
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0052183
name: obsolete disruption of symbiont cellular component
namespace: biological_process
alt_id: GO:0052187
alt_id: GO:0052367
def: "OBSOLETE. The process in which a host organism destabilizes a cellular component of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "degradation of symbiont cellular component by organism" RELATED []
synonym: "disassembly by host of symbiont cellular component" NARROW []
synonym: "disruption by host of symbiont cellular component" RELATED []
synonym: "disruption by host of symbiont structure" EXACT []
synonym: "modification by host of symbiont cellular component" EXACT []
synonym: "modification by host of symbiont structure" BROAD []
synonym: "perturbation of symbiont cellular component" EXACT []
is_obsolete: true

[Term]
id: GO:0052184
name: obsolete modulation by organism of symbiont hormone or growth regulator levels
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont hormone or growth regulator levels" EXACT []
is_obsolete: true

[Term]
id: GO:0052185
name: obsolete modification of structure of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modification of structure of other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052188
name: obsolete modification of cellular component in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modification of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052189
name: obsolete modulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
alt_id: GO:0052090
alt_id: GO:0052285
alt_id: GO:0052310
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process.
synonym: "modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of defense-related host callose deposition" BROAD []
is_obsolete: true

[Term]
id: GO:0052190
name: obsolete modulation by symbiont of host phagocytosis
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0052191
name: obsolete positive regulation by symbiont of host phagocytosis
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by symbiont of host phagocytosis" NARROW []
synonym: "stimulation by symbiont of host phagocytosis" NARROW []
synonym: "up regulation by symbiont of host phagocytosis" EXACT []
synonym: "up-regulation by symbiont of host phagocytosis" EXACT []
synonym: "upregulation by symbiont of host phagocytosis" EXACT []
is_obsolete: true

[Term]
id: GO:0052192
name: obsolete movement in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represented both a process and a location.
synonym: "locomotion in environment of other organism during symbiotic interaction" RELATED []
synonym: "movement in environment of other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052193
name: obsolete movement in symbiont environment
namespace: biological_process
def: "OBSOLETE. The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_obsolete: true

[Term]
id: GO:0052194
name: obsolete movement on or near symbiont
namespace: biological_process
def: "OBSOLETE. The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_obsolete: true

[Term]
id: GO:0052195
name: obsolete movement on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represented both a process and a location.
synonym: "movement on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052196
name: obsolete negative regulation by host of symbiont defense response
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction.
synonym: "down regulation by host of symbiont defense response" EXACT []
synonym: "down-regulation by host of symbiont defense response" EXACT []
synonym: "downregulation by host of symbiont defense response" EXACT []
synonym: "inhibition by host of symbiont defense response" NARROW []
is_obsolete: true

[Term]
id: GO:0052197
name: obsolete positive regulation by host of symbiont defense response
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response.
synonym: "activation by host of symbiont defense response" NARROW []
synonym: "stimulation by host of symbiont defense response" NARROW []
synonym: "up regulation by host of symbiont defense response" EXACT []
synonym: "up-regulation by host of symbiont defense response" EXACT []
synonym: "upregulation by host of symbiont defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052198
name: obsolete modulation of peptidase activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation of protease activity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation of protease activity in other organism involved in symbiotic interaction" NARROW [GOC:bf]
is_obsolete: true

[Term]
id: GO:0052199
name: obsolete negative regulation of catalytic activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it was an unnecessary grouping term.
synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "inhibition of enzyme activity in other organism" EXACT []
synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052200
name: symbiont-mediated response to host defenses
namespace: biological_process
alt_id: GO:0075140
alt_id: GO:0075145
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "maintenance of symbiont tolerance to host defense molecules" NARROW []
synonym: "response of symbiont to host defense molecules" NARROW []
synonym: "response to host defense molecules" NARROW []
synonym: "response to host defenses" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0052201
name: obsolete response to symbiont defenses
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it is covered by immune response ; GO:0006955 and children.
is_obsolete: true
consider: GO:0006955

[Term]
id: GO:0052202
name: obsolete negative regulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
alt_id: GO:0052087
alt_id: GO:0052282
alt_id: GO:0052311
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process.
synonym: "down regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "down-regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "downregulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "inhibition by symbiont of defense-related host cell wall callose deposition" NARROW []
synonym: "negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of defense-related host callose deposition" BROAD []
is_obsolete: true

[Term]
id: GO:0052203
name: obsolete modulation of catalytic activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modulation of enzyme activity within other organism during symbiotic interaction" EXACT [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052204
name: obsolete negative regulation of molecular function in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of protein function in other organism" EXACT []
synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0052205
name: obsolete modulation of molecular function in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modification of molecular function in other organism during symbiotic interaction" EXACT []
synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
synonym: "modulation of molecular function in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052206
name: obsolete modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052207
name: obsolete modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052208
name: obsolete modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052209
name: obsolete interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052210
name: obsolete interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "interaction with other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052211
name: obsolete interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "interaction with other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052212
name: obsolete modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "modification of host morphology or physiology via effector molecule" NARROW []
synonym: "modification of host morphology or physiology via ellicitor" NARROW []
synonym: "modification of morphology or physiology of other organism via secreted substance during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052213
name: obsolete interaction with symbiont via secreted substance
namespace: biological_process
def: "OBSOLETE. An interaction with a symbiont organism mediated by a substance secreted by a host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that this process was not clearly defined, and probably represented some immune response. .
synonym: "interaction with symbiont via secreted substance during symbiotic interaction" RELATED [GOC:dph]
synonym: "interaction with symbiont via secreted substance involved in symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052214
name: obsolete metabolism of substance in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "metabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052215
name: obsolete energy taxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "energy taxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052216
name: obsolete chemotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "chemotaxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052217
name: obsolete aerotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "aerotaxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052218
name: obsolete positive energy taxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive energy taxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052219
name: obsolete negative energy taxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative energy taxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052220
name: obsolete positive aerotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive aerotaxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052221
name: obsolete positive chemotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive chemotaxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052222
name: obsolete negative aerotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative aerotaxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052223
name: obsolete negative chemotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative chemotaxis in response to environment of other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052224
name: obsolete energy taxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "energy taxis within other organism during symbiotic interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0052225
name: obsolete energy taxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052226
name: obsolete biosynthesis of substance in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "biosynthesis of substance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052227
name: obsolete catabolism of substance in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052228
name: obsolete metabolism by symbiont of host protein
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052229
name: obsolete metabolism of macromolecule in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "metabolism of macromolecule in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052230
name: obsolete modulation of intracellular transport in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modulation of intracellular trafficking in other organism" EXACT []
synonym: "modulation of intracellular transport in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052231
name: obsolete modulation of phagocytosis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052232
name: obsolete positive aerotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052233
name: obsolete positive aerotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive aerotaxis within other organism during symbiotic interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0052234
name: obsolete negative aerotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052235
name: obsolete negative aerotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative aerotaxis within other organism during symbiotic interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0052236
name: obsolete negative chemotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052237
name: obsolete aerotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "aerotaxis within other organism during symbiotic interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0052238
name: obsolete aerotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052239
name: obsolete negative chemotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative chemotaxis within other organism during symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052240
name: obsolete positive chemotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive chemotaxis within other organism during symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052241
name: obsolete positive chemotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052242
name: obsolete chemotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "chemotaxis within other organism during symbiotic interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0052243
name: obsolete chemotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052244
name: obsolete negative energy taxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative energy taxis within other organism during symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052245
name: obsolete negative energy taxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "negative energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052246
name: obsolete positive energy taxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052247
name: obsolete positive energy taxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents both a process and a location.
synonym: "positive energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive energy taxis within other organism during symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052249
name: obsolete modulation of RNA levels in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modulation of RNA levels in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052257
name: obsolete pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
comment: This term was obsoleted because it has been misused.
synonym: "general elicitor dependent induction of innate immunity of other organism" EXACT []
synonym: "general elicitor-dependent induction of innate immunity of other organism" EXACT []
synonym: "MAMP dependent induction of innate immunity of other organism" EXACT []
synonym: "MAMP-dependent induction of innate immunity of other organism" EXACT []
synonym: "PAMP dependent induction of innate immunity of other organism" EXACT []
synonym: "PAMP-dependent induction of innate immunity of other organism" EXACT []
synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interaction" EXACT [GOC:pg]
is_obsolete: true
consider: GO:0002221
consider: GO:0002752
consider: GO:0052034

[Term]
id: GO:0052308
name: obsolete pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
comment: This term was obsoleted because it has been misused.
synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT [GOC:pg]
is_obsolete: true
consider: GO:0002221
consider: GO:0002752
consider: GO:0052034

[Term]
id: GO:0052312
name: obsolete modulation of transcription in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modulation of transcription in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052313
name: obsolete modulation of nutrient release from other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modulation of nutrient release from other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052314
name: phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin]
subset: goslim_pir
synonym: "phytoalexin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0052315
name: phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [PMID:22209038, PMID:3882051, Wikipedia:Phytoalexin]
synonym: "phytoalexin biosynthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052316
name: phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai]
synonym: "phytoalexin catabolism" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052317
name: camalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving camalexin, an indole phytoalexin." [GOC:ai]
synonym: "camalexin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046217 ! indole phytoalexin metabolic process

[Term]
id: GO:0052318
name: obsolete regulation of phytoalexin metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "regulation of phytoalexin metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0052319
name: obsolete regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "regulation of phytoalexin biosynthesis" EXACT []
is_obsolete: true

[Term]
id: GO:0052320
name: obsolete positive regulation of phytoalexin metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "activation of phytoalexin metabolism" NARROW []
synonym: "positive regulation of phytoalexin metabolism" RELATED []
synonym: "stimulation of phytoalexin metabolism" NARROW []
synonym: "up regulation of phytoalexin metabolism" EXACT []
synonym: "up-regulation of phytoalexin metabolism" EXACT []
synonym: "upregulation of phytoalexin metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0052321
name: obsolete negative regulation of phytoalexin metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:ai]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "down regulation of phytoalexin metabolism" EXACT []
synonym: "down-regulation of phytoalexin metabolism" EXACT []
synonym: "downregulation of phytoalexin metabolism" EXACT []
synonym: "inhibition of phytoalexin metabolism" NARROW []
synonym: "negative regulation of phytoalexin metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0052322
name: positive regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:mtg_pamgo_17jul06]
synonym: "activation of phytoalexin biosynthesis" NARROW []
synonym: "positive regulation of phytoalexin biosynthesis" EXACT []
synonym: "stimulation of phytoalexin biosynthesis" NARROW []
synonym: "up regulation of phytoalexin biosynthesis" EXACT []
synonym: "up-regulation of phytoalexin biosynthesis" EXACT []
synonym: "upregulation of phytoalexin biosynthesis" EXACT []
is_a: GO:0140546 ! defense response to symbiont
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
relationship: positively_regulates GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0052323
name: obsolete negative regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host phytoalexin production ; GO:1990217.
synonym: "down regulation of phytoalexin biosynthesis" EXACT []
synonym: "down-regulation of phytoalexin biosynthesis" EXACT []
synonym: "downregulation of phytoalexin biosynthesis" EXACT []
synonym: "inhibition of phytoalexin biosynthesis" NARROW []
synonym: "negative regulation of phytoalexin biosynthesis" EXACT []
is_obsolete: true
replaced_by: GO:1990217

[Term]
id: GO:0052324
name: plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall cellulose biosynthesis" EXACT []
synonym: "cellulose biosynthesis during cell wall biosynthesis" RELATED []
is_a: GO:0030244 ! cellulose biosynthetic process
is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process
is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0052325
name: cell wall pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall pectin biosynthesis" EXACT []
synonym: "pectin biosynthesis during cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045489 ! pectin biosynthetic process
is_a: GO:0052546 ! cell wall pectin metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0052326
name: obsolete interaction with symbiont via protein secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "interaction with symbiont via protein secreted by type IV secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052327
name: obsolete interaction with symbiont via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "interaction with symbiont via protein secreted by type II secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052328
name: obsolete interaction with symbiont via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "interaction with symbiont via protein secreted by type III secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052331
name: obsolete hemolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "haemolysis in other organism involved in symbiotic interaction" EXACT []
synonym: "hemolysin activity" RELATED []
synonym: "hemolysis by organism of erythrocytes in other organism during symbiotic interaction" RELATED []
synonym: "hemolysis by organism of RBCs in other organism during symbiotic interaction" RELATED [CL:0000232]
synonym: "hemolysis by organism of red blood cells in other organism during symbiotic interaction" RELATED [CL:0000232]
synonym: "hemolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "hemolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0052332
name: obsolete modification by organism of membrane in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a cellular membrane of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modification by organism of cell membrane in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modification by organism of cell membrane in other organism involved in symbiotic interaction" NARROW [GOC:bf, GOC:jl]
is_obsolete: true

[Term]
id: GO:0052333
name: obsolete modification by organism of cell wall of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "metabolism by organism of cell wall of other organism" RELATED []
synonym: "modification by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052334
name: obsolete modification by organism of cytoskeleton of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "modification by organism of cytoskeleton of other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052335
name: obsolete modification by host of symbiont cytoskeleton
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was too vague.
is_obsolete: true

[Term]
id: GO:0052336
name: obsolete modification by host of symbiont cell wall
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it was too vague.
synonym: "metabolism of symbiont cell wall by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052337
name: obsolete disruption by host of symbiont membrane
namespace: biological_process
def: "OBSOLETE. The process in which a host organism destabilizes a symbiont membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it was redundant with other terms: antimicrobial humoral immune response mediated by antimicrobial peptide ; GO:0061844 and killing by host of symbiont cells ; GO:0051873.
synonym: "modification by host of symbiont cell membrane" NARROW [GOC:bf, GOC:jl]
synonym: "modification by host of symbiont membrane" RELATED []
is_obsolete: true
consider: GO:0051873
consider: GO:0061844

[Term]
id: GO:0052338
name: obsolete perturbation by host of symbiont cell wall
namespace: biological_process
def: "OBSOLETE. The perturbation by an organism of the symbiont cell wall, leading to damage or temporary subversion of the cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it was redundant with other terms: antimicrobial humoral immune response mediated by antimicrobial peptide ; GO:0061844 and killing by host of symbiont cells ; GO:0051873.
synonym: "catabolism of symbiont cell wall by organism" EXACT []
synonym: "degradation of symbiont cell wall by organism" EXACT []
synonym: "disassembly by host of symbiont cell wall" EXACT []
synonym: "disruption by host of symbiont cell wall" RELATED []
is_obsolete: true
consider: GO:0051873
consider: GO:0061844

[Term]
id: GO:0052339
name: obsolete disruption by organism of cell wall of other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "disassembly by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052340
name: obsolete catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052341
name: obsolete catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052342
name: obsolete catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052343
name: obsolete positive regulation by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052344
name: obsolete positive regulation by symbiont of host phytoalexin production
namespace: biological_process
alt_id: GO:0052329
def: "OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by symbiont of host phytoalexin production" NARROW []
synonym: "positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction" BROAD []
synonym: "stimulation by symbiont of host phytoalexin production" NARROW []
synonym: "up regulation by symbiont of host phytoalexin production" EXACT []
synonym: "up-regulation by symbiont of host phytoalexin production" EXACT []
synonym: "upregulation by symbiont of host phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052346
name: obsolete positive regulation by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont nitric oxide production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052349
name: obsolete positive regulation by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont AOS production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont ROI production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052350
name: obsolete induction by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of induced systemic resistance in symbiont" EXACT []
synonym: "activation by organism of ISR in symbiont" EXACT []
synonym: "induction by organism of induced systemic resistance in symbiont" EXACT []
synonym: "induction by organism of ISR in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052351
name: obsolete induction by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of SAR in symbiont" EXACT []
synonym: "activation by organism of systemic acquired resistance in symbiont" EXACT []
synonym: "induction by organism of SAR in symbiont" EXACT []
synonym: "induction by organism of systemic acquired resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052352
name: obsolete biosynthesis by host of substance in symbiont
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0052353
name: obsolete catabolism by host of symbiont carbohydrate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052354
name: obsolete catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
synonym: "catabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052355
name: obsolete catabolism by host of symbiont cell wall cellulose
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052356
name: obsolete catabolism by host of symbiont cell wall chitin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:11085997]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052357
name: obsolete catabolism by host of symbiont cell wall pectin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because there is no evidence it exists.
is_obsolete: true

[Term]
id: GO:0052358
name: obsolete catabolism by host of symbiont glucan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because there is no evidence it exists.
is_obsolete: true

[Term]
id: GO:0052359
name: obsolete catabolism by organism of glucan in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052360
name: obsolete catabolism by host of symbiont macromolecule
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052361
name: obsolete catabolism by organism of macromolecule in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism by organism of macromolecule in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052362
name: obsolete catabolism by host of symbiont protein
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052363
name: obsolete catabolism by organism of protein in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052364
name: obsolete catabolism by host of substance in symbiont
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052365
name: obsolete catabolism by host of symbiont xylan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because there is no evidence it exists.
is_obsolete: true

[Term]
id: GO:0052366
name: obsolete catabolism by organism of xylan in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052368
name: obsolete disruption by organism of cellular component in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "catabolism of cellular component in other organism" EXACT []
synonym: "catabolism of structural constituent in other organism" EXACT []
synonym: "degradation of cellular component in other organism" EXACT []
synonym: "disassembly by organism of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "disassembly by organism of cellular component in other organism involved in symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052372
name: modulation by symbiont of entry into host
namespace: biological_process
alt_id: GO:0052371
def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "regulation by organism of entry into other organism involved in symbiotic interaction" RELATED []
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
relationship: regulates GO:0044409 ! symbiont entry into host

[Term]
id: GO:0052373
name: suppression of symbiont entry into host
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of entry into other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative regulation by organism of entry into other organism involved in symbiotic interaction" BROAD []
synonym: "suppression of symbiont entry into host by host" EXACT []
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0052374
name: obsolete negative regulation by symbiont of entry into host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "down regulation by symbiont of entry into host" EXACT []
synonym: "down-regulation by symbiont of entry into host" EXACT []
synonym: "downregulation by symbiont of entry into host" EXACT []
synonym: "inhibition by symbiont of entry into host" NARROW []
is_obsolete: true

[Term]
id: GO:0052375
name: obsolete evasion or tolerance by organism of symbiont-produced nitric oxide
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion or tolerance by organism of symbiont nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of symbiont NO" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced NO" EXACT []
synonym: "evasion or tolerance of nitric oxide produced by symbiont in response to organism" EXACT []
synonym: "evasion or tolerance of NO produced by symbiont in response to organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052377
name: obsolete evasion or tolerance by organism of symbiont-produced phytoalexins
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion or tolerance by organism of symbiont phytoalexins" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by symbiont in response to organism" EXACT []
synonym: "symbiont phytoalexin detoxification" NARROW []
is_obsolete: true

[Term]
id: GO:0052379
name: obsolete modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction" RELATED []
synonym: "modulation by organism of entry into other organism via phagocytosis during symbiotic interaction" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0052381
name: tRNA dimethylallyltransferase activity
namespace: molecular_function
alt_id: GO:0004811
def: "Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine." [EC:2.5.1.75]
comment: Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.
synonym: "dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity" EXACT systematic_synonym [EC:2.5.1.75]
synonym: "tRNA isopentenyltransferase activity" RELATED [GOC:mah, GOC:vw]
synonym: "tRNA prenyltransferase activity" BROAD [EC:2.5.1.75]
xref: EC:2.5.1.75
xref: MetaCyc:RXN0-6274
xref: Reactome:R-HSA-6784462 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs"
xref: Reactome:R-HSA-6787567 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)"
xref: RHEA:26482
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0052383
name: obsolete induction by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont innate immune response" EXACT []
synonym: "activation by organism of symbiont innate immunity" EXACT []
synonym: "induction by organism of symbiont innate immune response" EXACT []
synonym: "induction by organism of symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052384
name: obsolete evasion or tolerance by organism of symbiont-produced reactive oxygen species
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion by organism of cellular damage caused by symbiont oxidative burst" NARROW []
synonym: "evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced reactive oxygen species" EXACT []
synonym: "evasion or tolerance of defense-related symbiont metabolic burst" EXACT []
synonym: "evasion or tolerance of defense-related symbiont oxidative burst" EXACT []
synonym: "evasion or tolerance of defense-related symbiont respiratory burst" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by symbiont in response to organism" EXACT []
synonym: "evasion or tolerance of symbiont-produced active oxygen species" EXACT []
synonym: "evasion or tolerance of symbiont-produced AOS" EXACT []
synonym: "evasion or tolerance of symbiont-produced reactive oxygen intermediates" EXACT []
synonym: "evasion or tolerance of symbiont-produced ROIs" EXACT []
synonym: "evasion or tolerance of symbiont-produced ROS" EXACT []
is_obsolete: true

[Term]
id: GO:0052386
name: cell wall thickening
namespace: biological_process
def: "A type of cell wall modification in which the cell wall is reinforced and made thicker." [GOC:mtg_pamgo_17jul06]
is_a: GO:0042545 ! cell wall modification

[Term]
id: GO:0052387
name: obsolete induction by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont apoptosis" EXACT []
synonym: "activation by organism of symbiont apoptotic programmed cell death" EXACT []
synonym: "induction by organism of symbiont apoptosis" EXACT []
synonym: "induction by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052390
name: obsolete induction by symbiont of host innate immune response
namespace: biological_process
alt_id: GO:0052166
alt_id: GO:0052305
alt_id: GO:0052382
def: "OBSOLETE. The activation by a symbiont of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that this terms was not clearly defined and has been incorrectly used.
synonym: "activation by organism of host innate immune response" EXACT []
synonym: "activation by organism of host innate immunity" EXACT []
synonym: "activation by symbiont of host innate immunity" EXACT []
synonym: "induction by organism of host innate immune response" RELATED []
synonym: "induction by organism of innate immune response in other organism involved in symbiotic interaction" BROAD []
synonym: "induction by symbiont of host innate immunity" EXACT []
synonym: "induction of host innate immunity" EXACT []
synonym: "positive regulation by symbiont of host innate immune response" RELATED []
synonym: "positive regulation by symbiont of host innate immunity" RELATED []
synonym: "positive regulation of host innate immune response" RELATED []
synonym: "positive regulation of innate immune response in other organism" BROAD []
synonym: "stimulation by symbiont of host innate immunity" RELATED []
synonym: "up regulation by symbiont of host innate immunity" RELATED []
synonym: "up-regulation by symbiont of host innate immunity" RELATED []
synonym: "upregulation by symbiont of host innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052391
name: obsolete induction by symbiont of defense-related host calcium ion flux
namespace: biological_process
def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidece that this process exists.
synonym: "activation by organism of host Ca2+ flux" EXACT []
synonym: "activation by organism of host calcium ion flux" EXACT []
synonym: "activation by symbiont of defense-related host calcium ion flux" EXACT []
synonym: "induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD []
synonym: "induction by organism of host Ca2+ flux" EXACT []
synonym: "positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by organism of defense-related host Ca2+ flux" RELATED []
synonym: "positive regulation by symbiont of defense-related host calcium ion flux" RELATED []
synonym: "stimulation by symbiont of defense-related host calcium ion flux" RELATED []
synonym: "up regulation by symbiont of defense-related host calcium ion flux" RELATED []
synonym: "up-regulation by symbiont of defense-related host calcium ion flux" RELATED []
synonym: "upregulation by symbiont of defense-related host calcium ion flux" RELATED []
is_obsolete: true

[Term]
id: GO:0052392
name: obsolete induction by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont Ca2+ flux" EXACT []
synonym: "activation by organism of symbiont calcium ion flux" EXACT []
synonym: "induction by organism of defense-related symbiont calcium ion flux" EXACT []
synonym: "induction by organism of symbiont Ca2+ flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052393
name: obsolete induction by host of symbiont defense response
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response.
synonym: "activation of symbiont defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052394
name: obsolete induction by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont defense-related cell wall thickening" EXACT []
synonym: "activation by organism of symbiont defensive cell wall thickening" EXACT []
synonym: "induction by organism of defense-related symbiont cell wall thickening" EXACT []
synonym: "induction by organism of symbiont defensive cell wall thickening" EXACT []
is_obsolete: true

[Term]
id: GO:0052395
name: obsolete induction by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont nitric acid production" EXACT []
synonym: "activation by organism of defense-related symbiont NO production" EXACT []
synonym: "induction by organism of defense-related symbiont nitric oxide production" EXACT []
synonym: "induction by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052396
name: obsolete induction by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont non-apoptotic programmed cell death" EXACT []
synonym: "induction by organism of symbiont non-apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052398
name: obsolete induction by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont phytoalexin production" EXACT []
synonym: "induction by organism of symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052399
name: obsolete induction by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont programmed cell death" EXACT []
synonym: "induction by organism of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052401
name: obsolete induction by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "activation by organism of defense-related symbiont AOS production" EXACT []
synonym: "activation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "activation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "activation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "activation by organism of defense-related symbiont ROI production" EXACT []
synonym: "activation by organism of defense-related symbiont ROS production" EXACT []
synonym: "induction by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "induction by organism of defense-related symbiont AOS production" EXACT []
synonym: "induction by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "induction by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "induction by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "induction by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "induction by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "induction by organism of defense-related symbiont ROI production" EXACT []
synonym: "induction by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052402
name: obsolete induction by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "activation by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "activation by organism of symbiont resistance gene-dependent defense response" EXACT []
synonym: "induction by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "induction by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "induction by organism of symbiont resistance gene-dependent defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052403
name: obsolete negative regulation by host of symbiont catalytic activity
namespace: biological_process
alt_id: GO:0052405
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation by host of symbiont enzyme activity" EXACT []
synonym: "down regulation by host of symbiont protein function" BROAD []
synonym: "down-regulation by host of symbiont enzyme activity" EXACT []
synonym: "down-regulation by host of symbiont protein function" BROAD []
synonym: "downregulation by host of symbiont enzyme activity" EXACT []
synonym: "downregulation by host of symbiont protein function" BROAD []
synonym: "inhibition by host of symbiont enzyme activity" NARROW []
synonym: "inhibition by host of symbiont protein function" NARROW []
synonym: "inhibition of symbiont enzyme activity" EXACT []
synonym: "inhibition of symbiont protein function" BROAD []
synonym: "negative regulation by host of symbiont enzyme activity" EXACT []
synonym: "negative regulation by host of symbiont molecular function" BROAD []
is_obsolete: true

[Term]
id: GO:0052404
name: obsolete negative regulation by host of symbiont peptidase activity
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation by host of symbiont protease activity" NARROW []
synonym: "down-regulation by host of symbiont protease activity" NARROW []
synonym: "downregulation by host of symbiont protease activity" NARROW []
synonym: "inhibition by host of symbiont protease activity" NARROW []
synonym: "inhibition of symbiont protease activity" NARROW []
synonym: "negative regulation by host of symbiont protease activity" NARROW [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0052406
name: obsolete metabolism by host of symbiont carbohydrate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052407
name: obsolete metabolism by organism of carbohydrate in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "metabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052408
name: obsolete metabolism by host of symbiont cell wall cellulose
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052409
name: obsolete metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "metabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052410
name: obsolete metabolism by host of symbiont cell wall chitin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052411
name: obsolete metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "metabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052412
name: obsolete metabolism by host of symbiont cell wall pectin
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence it exists.
is_obsolete: true

[Term]
id: GO:0052414
name: obsolete metabolism by host of symbiont glucan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052415
name: obsolete metabolism by organism of glucan in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "metabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052416
name: obsolete metabolism by host of symbiont macromolecule
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052417
name: obsolete metabolism by host of symbiont protein
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052418
name: obsolete metabolism by organism of protein in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "metabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052419
name: obsolete metabolism by host of substance in symbiont
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0052420
name: obsolete metabolism by host of symbiont xylan
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence it exists.
is_obsolete: true

[Term]
id: GO:0052421
name: obsolete metabolism by organism of xylan in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was deprecated because it represents an unnecessary grouping class.
synonym: "metabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052422
name: obsolete modulation by host of symbiont catalytic activity
namespace: biological_process
alt_id: GO:0052428
def: "OBSOLETE. The process in which a host organism effects a change in the enzyme activity of its symbiont organism." [GOC:mtg_pamgo_17jul06, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation by host of symbiont enzyme activity" EXACT [GOC:tb]
synonym: "modulation by host of symbiont molecular function" BROAD []
is_obsolete: true

[Term]
id: GO:0052424
name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052425
name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052426
name: obsolete modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052427
name: obsolete modulation by host of symbiont peptidase activity
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in symbiont peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation by host of symbiont protease activity" NARROW [GOC:bf]
is_obsolete: true

[Term]
id: GO:0052429
name: obsolete modulation by organism of symbiont B-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont B-cell mediated immune response" EXACT []
synonym: "regulation by organism of symbiont B-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052430
name: obsolete modulation by host of symbiont RNA levels
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents a readout.
is_obsolete: true

[Term]
id: GO:0052431
name: obsolete modulation by organism of symbiont T-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont T-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052432
name: obsolete modulation by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont apoptosis" EXACT []
synonym: "modulation by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052434
name: obsolete modulation by organism of symbiont cell-mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont cell-based immune response" EXACT []
synonym: "modulation by organism of symbiont cell-mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052435
name: obsolete modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism" EXACT []
synonym: "modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052436
name: obsolete modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT []
synonym: "modulation by organism of defense-related symbiont CDPK pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052437
name: obsolete modulation by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont Ca2+ flux" EXACT []
synonym: "modulation by organism of defense-related symbiont calcium ion flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052438
name: obsolete modulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052439
name: obsolete modulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont cell wall callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052440
name: obsolete modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052442
name: obsolete modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "modulation of defense-related symbiont JA-mediated signal transduction pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052444
name: obsolete modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "modulation of defense-related symbiont SA-mediated signal transduction pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052446
name: obsolete modulation by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont cell wall thickening" EXACT []
synonym: "modulation by organism of symbiont defensive cell wall thickening" RELATED []
is_obsolete: true

[Term]
id: GO:0052447
name: obsolete modulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont ethylene-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052448
name: obsolete modulation by organism of ethylene levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of ethylene levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052450
name: obsolete modulation by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of induced systemic resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052451
name: obsolete modulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont inflammatory response" EXACT []
is_obsolete: true

[Term]
id: GO:0052452
name: obsolete modulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont innate immunity" EXACT []
synonym: "modulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052453
name: obsolete modulation by organism of symbiont intracellular transport
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont intracellular transport" EXACT []
synonym: "modulation of symbiont intracellular trafficking" EXACT []
is_obsolete: true

[Term]
id: GO:0052454
name: obsolete modulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont JA-mediated defense response" EXACT []
synonym: "modulation by organism of symbiont jasmonic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052455
name: obsolete modulation by organism of jasmonic acid levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of jasmonic acid levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052457
name: obsolete modulation by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont nitric oxide production" EXACT []
synonym: "modulation by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052458
name: obsolete modulation by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont non-apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052460
name: modulation of nutrient release by symbiont
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by host of nutrient release from symbiont" EXACT []
is_a: GO:0051851 ! modulation by host of symbiont process
relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont

[Term]
id: GO:0052461
name: obsolete modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052462
name: obsolete modulation by host of symbiont phagocytosis
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0052463
name: obsolete modulation by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052464
name: obsolete modulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont programmed cell death" EXACT []
synonym: "modulation of symbiont HR" BROAD []
synonym: "modulation of symbiont hypersensitive response" NARROW []
synonym: "modulation of symbiont PCD" EXACT []
is_obsolete: true

[Term]
id: GO:0052465
name: obsolete modulation by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "modulation by organism of defense-related symbiont AOS production" EXACT []
synonym: "modulation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "modulation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "modulation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "modulation by organism of defense-related symbiont ROI production" EXACT []
synonym: "modulation by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052466
name: obsolete modulation by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "modulation by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "modulation by organism of symbiont resistance gene-dependent defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052467
name: obsolete modulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont SA-mediated defense response" EXACT []
synonym: "modulation by organism of symbiont salicylic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052468
name: obsolete modulation by organism of salicylic acid levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of salicylic acid levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052470
name: obsolete modulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0052471
name: obsolete modulation by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of systemic acquired resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052472
name: modulation by host of symbiont transcription
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modulation by host of symbiont process

[Term]
id: GO:0052473
name: obsolete negative regulation by organism of symbiont B-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont B-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052474
name: obsolete negative regulation by organism of symbiont T-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont T-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052475
name: obsolete negative regulation by organism of symbiont cell-mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont cell-based immune response" EXACT []
synonym: "negative regulation by organism of symbiont cell-mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052476
name: obsolete negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052477
name: obsolete negative regulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of defense-related symbiont callose deposition" EXACT []
synonym: "suppression by organism of defense-related symbiont callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052478
name: obsolete negative regulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "negative regulation by organism of defense-related symbiont cell wall callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052479
name: obsolete negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
synonym: "suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052480
name: obsolete negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052481
name: obsolete negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052482
name: defense response by cell wall thickening
namespace: biological_process
def: "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism." [GOC:mtg_pamgo_17jul06]
synonym: "cell wall thickening during defense response" RELATED [GOC:dph]
is_a: GO:0006952 ! defense response
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0052386 ! cell wall thickening

[Term]
id: GO:0052484
name: obsolete negative regulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont ethylene-mediated defense response" EXACT []
synonym: "suppression by organism of symbiont ethylene-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052485
name: obsolete negative regulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont inflammatory response" EXACT []
is_obsolete: true

[Term]
id: GO:0052486
name: obsolete negative regulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont innate immunity" EXACT []
synonym: "negative regulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052487
name: obsolete negative regulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT []
synonym: "suppression by organism of symbiont JA-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052488
name: obsolete negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT []
synonym: "suppression of general elicitor induced symbiont innate immunity" EXACT []
synonym: "suppression of general elicitor-induced symbiont innate immunity" EXACT []
synonym: "suppression of MAMP induced symbiont innate immunity" EXACT []
synonym: "suppression of MAMP-induced symbiont innate immunity" EXACT []
synonym: "suppression of PAMP induced symbiont innate immunity" EXACT []
synonym: "suppression of PAMP-induced symbiont innate immunity" EXACT []
synonym: "suppression of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052489
name: obsolete negative regulation by host of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "down regulation by host of symbiont programmed cell death" EXACT []
synonym: "down-regulation by host of symbiont programmed cell death" EXACT []
synonym: "downregulation by host of symbiont programmed cell death" EXACT []
synonym: "inhibition by host of symbiont programmed cell death" NARROW []
synonym: "inhibition of symbiont programmed cell death" EXACT []
is_obsolete: true
consider: GO:0052040

[Term]
id: GO:0052491
name: obsolete negative regulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont salicylic acid-mediated defense response" EXACT []
synonym: "negative regulation of symbiont SA-mediated defense response" EXACT []
synonym: "suppression by organism of symbiont salicylic acid-mediated defense response" EXACT []
synonym: "suppression of symbiont SA mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052492
name: obsolete negative regulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "down regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "down-regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "downregulation by host of symbiont signal transduction pathway" EXACT []
synonym: "inhibition by host of symbiont signal transduction pathway" NARROW []
synonym: "negative modulation by organism of symbiont signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052494
name: obsolete occlusion by host of symbiont vascular system
namespace: biological_process
def: "OBSOLETE. The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
comment: This term was obsoleted because this process is not known to exist.
is_obsolete: true

[Term]
id: GO:0052495
name: obsolete occlusion by organism of vascular system in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "occlusion by organism of vascular system in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052496
name: obsolete occlusion by host of symbiont xylem
namespace: biological_process
def: "OBSOLETE. The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because this process is not known to exist.
is_obsolete: true

[Term]
id: GO:0052497
name: obsolete occlusion by organism of xylem in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The process in which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "occlusion by organism of xylem in other organism during symbiotic interaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0052498
name: obsolete pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "general elicitor-dependent activation of symbiont innate immunity" EXACT []
synonym: "general elicitor-dependent induction of symbiont innate immunity" EXACT []
synonym: "MAMP dependent activation of symbiont innate immunity" EXACT []
synonym: "MAMP dependent induction of symbiont innate immunity" EXACT []
synonym: "PAMP dependent activation of symbiont innate immunity" EXACT []
synonym: "PAMP dependent induction of symbiont innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052499
name: obsolete pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052500
name: obsolete positive regulation by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont apoptosis" EXACT []
synonym: "positive regulation by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052502
name: obsolete positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052503
name: obsolete positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT []
synonym: "positive regulation of defense-related symbiont CDPK pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052504
name: obsolete positive regulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of defense-related papilla formation in symbiont" NARROW []
synonym: "induction by organism of defense-related symbiont callose deposition" NARROW []
synonym: "positive regulation by organism of defense-related papilla formation in symbiont" EXACT []
synonym: "positive regulation by organism of defense-related symbiont callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052505
name: obsolete positive regulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of defense-related symbiont cell wall callose deposition" NARROW []
synonym: "positive regulation by organism of defense-related symbiont cell wall callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052506
name: obsolete positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052507
name: obsolete positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052508
name: obsolete positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052511
name: obsolete positive regulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont ethylene-mediated defense response" NARROW []
synonym: "induction by organism of symbiont ethylene-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont ethylene-mediated defense response" EXACT []
synonym: "upregulation by organism of symbiont ethylene-mediated defense response" NARROW []
is_obsolete: true

[Term]
id: GO:0052512
name: obsolete positive regulation by organism of hormone or growth regulator levels in symbiont
namespace: biological_process
def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive modulation of hormone or growth regulator levels in symbiont" EXACT []
synonym: "positive regulation by organism of hormone or growth regulator levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052514
name: obsolete positive regulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont inflammatory response" EXACT []
is_obsolete: true

[Term]
id: GO:0052515
name: obsolete positive regulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont innate immunity" EXACT []
synonym: "positive regulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052516
name: obsolete positive regulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont JA-mediated defense response" NARROW []
synonym: "induction by organism of symbiont jasmonic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont JA-mediated defense response" EXACT []
synonym: "positive regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052517
name: obsolete positive regulation by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont non-apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052519
name: positive regulation of nutrient release by symbiont
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of nutrient release from symbiont" NARROW []
synonym: "positive regulation by host of nutrient release from symbiont" EXACT []
synonym: "promotion of nutrient release from symbiont" EXACT []
synonym: "stimulation by host of nutrient release from symbiont" NARROW []
synonym: "up regulation by host of nutrient release from symbiont" EXACT []
synonym: "up-regulation by host of nutrient release from symbiont" EXACT []
synonym: "upregulation by host of nutrient release from symbiont" EXACT []
is_a: GO:0052460 ! modulation of nutrient release by symbiont

[Term]
id: GO:0052520
name: obsolete positive regulation by organism of nutrient release from other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "activation by organism of nutrient release from other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "promotion of nutrient release from other organism" EXACT []
synonym: "stimulation by organism of nutrient release from other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of nutrient release from other organism during symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052521
name: obsolete positive regulation by host of symbiont phagocytosis
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by host of symbiont phagocytosis" NARROW []
synonym: "stimulation by host of symbiont phagocytosis" NARROW []
synonym: "up regulation by host of symbiont phagocytosis" EXACT []
synonym: "up-regulation by host of symbiont phagocytosis" EXACT []
synonym: "upregulation by host of symbiont phagocytosis" EXACT []
is_obsolete: true

[Term]
id: GO:0052522
name: obsolete positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "activation by organism of phagocytosis in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of phagocytosis in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED []
is_obsolete: true

[Term]
id: GO:0052523
name: obsolete positive regulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "enhancement or induction of symbiont programmed cell death" EXACT []
synonym: "positive regulation by organism of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052524
name: obsolete positive regulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont SA-mediated defense response" NARROW []
synonym: "induction by organism of symbiont salicylic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont SA-mediated defense response" EXACT []
synonym: "positive regulation by organism of symbiont salicylic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052525
name: obsolete positive regulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "activation by host of symbiont signal transduction pathway" NARROW []
synonym: "stimulation by host of symbiont signal transduction pathway" NARROW []
synonym: "up regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "up-regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "upregulation by host of symbiont signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052528
name: obsolete upregulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "enhancement of symbiont programmed cell death by organism" EXACT []
synonym: "upregulation by organism of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052530
name: obsolete positive regulation by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "positive regulation by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "positive regulation by organism of symbiont resistance gene-dependent defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052531
name: obsolete positive regulation by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont Ca2+ flux" EXACT []
synonym: "positive regulation by organism of defense-related symbiont calcium ion flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052534
name: obsolete positive regulation by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of induced systemic resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052536
name: obsolete positive regulation by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of systemic acquired resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052540
name: obsolete positive regulation by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont cell wall thickening" EXACT []
synonym: "positive regulation by organism of symbiont defensive cell wall thickening" EXACT []
is_obsolete: true

[Term]
id: GO:0052541
name: plant-type cell wall cellulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:mah, ISBN:0198506732]
synonym: "cell wall cellulose metabolism" EXACT []
synonym: "cellulose and pectin-containing cell wall cellulose metabolic process" EXACT []
is_a: GO:0030243 ! cellulose metabolic process
is_a: GO:0034406 ! cell wall beta-glucan metabolic process
relationship: part_of GO:0009664 ! plant-type cell wall organization

[Term]
id: GO:0052542
name: defense response by callose deposition
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose deposition during defense response" RELATED [GOC:dph]
synonym: "callose localization during defense response" RELATED []
is_a: GO:0006952 ! defense response
is_a: GO:0009743 ! response to carbohydrate
is_a: GO:0052545 ! callose localization

[Term]
id: GO:0052543
name: callose deposition in cell wall
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose localization in cell wall" EXACT []
synonym: "cell wall callose deposition" EXACT []
synonym: "cell wall callose localization" EXACT []
is_a: GO:0052386 ! cell wall thickening
is_a: GO:0052545 ! callose localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0052544
name: defense response by callose deposition in cell wall
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose deposition in cell wall during defense response" RELATED [GOC:dph]
synonym: "callose localization in cell wall during defense response" EXACT []
synonym: "cell wall callose deposition during defense response" EXACT []
synonym: "cell wall callose localization during defense response" EXACT []
is_a: GO:0052482 ! defense response by cell wall thickening
is_a: GO:0052542 ! defense response by callose deposition
is_a: GO:0052543 ! callose deposition in cell wall
relationship: part_of GO:0006952 ! defense response

[Term]
id: GO:0052545
name: callose localization
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06, PMID:18397379]
synonym: "callose localisation" EXACT [GOC:mah]
is_a: GO:0033037 ! polysaccharide localization

[Term]
id: GO:0052546
name: cell wall pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall pectin metabolism" EXACT []
synonym: "cellulose and pectin-containing cell wall pectin metabolic process" EXACT []
synonym: "pectin metabolism during cell wall biogenesis" EXACT []
synonym: "plant-type cell wall pectin metabolic process" EXACT []
is_a: GO:0045488 ! pectin metabolic process
relationship: part_of GO:0009664 ! plant-type cell wall organization

[Term]
id: GO:0052547
name: regulation of peptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "peptidase regulator activity" RELATED []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0052548
name: regulation of endopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "protease regulator activity" NARROW []
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:0052553
name: symbiont-mediated perturbation of host immune response
namespace: biological_process
alt_id: GO:0052552
def: "A process in which a symbiont alters or subverts the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "modulation by symbiont of host immune response" EXACT []
synonym: "perturbation of host immune response" EXACT []
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0052554
name: obsolete modulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052557
name: obsolete positive regulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052559
name: obsolete induction by symbiont of host immune response
namespace: biological_process
alt_id: GO:0052555
alt_id: GO:0052556
alt_id: GO:0052558
def: "OBSOLETE. Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: The reason for obsoletion is that this terms was not clearly defined and has been incorrectly used.
synonym: "activation by symbiont of host immune response" EXACT []
synonym: "induction by organism of immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "positive regulation by symbiont of host immune response" RELATED []
synonym: "stimulation by symbiont of host immune response" RELATED []
synonym: "up regulation by symbiont of host immune response" RELATED []
synonym: "up-regulation by symbiont of host immune response" RELATED []
synonym: "upregulation by symbiont of host immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052560
name: obsolete induction by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052562
name: symbiont-mediated suppression of host immune response
namespace: biological_process
alt_id: GO:0052561
def: "A process in which a symbiont interferes with, inhibits or disrupts the normal execution of an immune response of the host organism. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of host immune response" EXACT []
synonym: "down-regulation by symbiont of host immune response" EXACT []
synonym: "downregulation by symbiont of host immune response" EXACT []
synonym: "inhibition by symbiont of host immune response" NARROW []
synonym: "negative regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD []
synonym: "negative regulation by symbiont of host immune response" EXACT []
synonym: "suppression by symbiont of host immune response" EXACT []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response

[Term]
id: GO:0052563
name: obsolete negative regulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052568
name: obsolete response to symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052569
name: obsolete response to defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to defense-related symbiont nitric oxide production" EXACT []
is_obsolete: true

[Term]
id: GO:0052570
name: obsolete response to defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to defense-related symbiont reactive oxygen species production" EXACT []
is_obsolete: true

[Term]
id: GO:0052571
name: obsolete response to symbiont immune response
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052572
name: response to host immune response
namespace: biological_process
alt_id: GO:0052564
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "response to immune response of other organism involved in symbiotic interaction" BROAD []
is_a: GO:0052200 ! symbiont-mediated response to host defenses

[Term]
id: GO:0052573
name: UDP-D-galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "UDP-D-galactopyranose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-D-galactopyranose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-D-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "uridine diphosphate galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "uridine diphosphate galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0052574
name: UDP-galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "UDP-alpha-D-galactose biosynthesis" EXACT [MetaCyc:PWY-7344]
synonym: "UDP-D-galactopyranose biosynthesis" EXACT []
synonym: "UDP-D-galactopyranose biosynthetic process" EXACT []
synonym: "UDP-D-galactose biosynthesis" EXACT []
synonym: "UDP-D-galactose biosynthetic process" EXACT []
synonym: "UDP-galactose biosynthesis" EXACT []
synonym: "uridine diphosphate galactose biosynthesis" EXACT []
synonym: "uridine diphosphate galactose biosynthetic process" EXACT []
xref: MetaCyc:PWY-7344
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0052573 ! UDP-D-galactose metabolic process

[Term]
id: GO:0052575
name: carbohydrate localization
namespace: biological_process
def: "Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah]
synonym: "carbohydrate localisation" EXACT [PMID:10758476]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0052576
name: carbohydrate storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [PMID:10758476]
is_a: GO:0052575 ! carbohydrate localization

[Term]
id: GO:0052577
name: germacrene-D synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate." [RHEA:12016]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-germacrene-D-forming] activity" EXACT [EC:4.2.3.75]
xref: EC:4.2.3.75
xref: KEGG_REACTION:R07648
xref: MetaCyc:RXN-8562
xref: RHEA:12016
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0052578
name: alpha-farnesene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate." [MetaCyc:RXN-8574]
synonym: "(E,E)-alpha-farnesene synthase activity" EXACT [MetaCyc:RXN-8574]
xref: MetaCyc:RXN-8574
xref: RHEA:27421
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0052579
name: (+)-pulegone reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,4S)-menthone + NADP+ = (R)-pulegone + H+ + NADPH. Also converts (2R,5R)-isomenthone into (R)-pulegone." [EC:1.3.1.81]
synonym: "(+)-isomenthone:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.81]
xref: EC:1.3.1.81
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052580
name: obsolete (+)-pulegone reductase, (-)-menthone as substrate, activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+." [GOC:curators]
comment: This term was obsoleted because it represents the same substrate as (+)-pulegone reductase (NADP+) activity; GO:0052579.
is_obsolete: true
replaced_by: GO:0052579

[Term]
id: GO:0052581
name: (-)-isopiperitenone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6R)-isoperitenone + H+ + NADPH = (2R,5R)-isopulegone + NADP+." [EC:1.3.1.82, RHEA:25649]
synonym: "(+)-cis-isopulegone:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.82]
xref: EC:1.3.1.82
xref: KEGG_REACTION:R06417
xref: MetaCyc:RXN-5161
xref: RHEA:25649
is_a: GO:0035671 ! enone reductase activity

[Term]
id: GO:0052582
name: (+)-menthofuran synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pulegone + reduced [NADPH--hemoprotein reductase] + O2 = (R)-menthofuran + 2 H2O + +H+ + oxidized [NADPH--hemoprotein reductase]." [RHEA:25658]
synonym: "(+)-MFS activity" BROAD [EC:1.14.14.143]
synonym: "(+)-pulegone 9-hydroxylase activity" RELATED [EC:1.14.14.143]
synonym: "(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity" RELATED [EC:1.14.14.143]
synonym: "cytochrome P450 menthofuran synthase activity" RELATED [EC:1.14.14.143]
synonym: "menthofuran synthase activity" RELATED [EC:1.14.14.143]
xref: EC:1.14.14.143
xref: KEGG_REACTION:R08923
xref: MetaCyc:1.14.13.104-RXN
xref: RHEA:25658
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052583
name: obsolete oxidoreductase activity, acting on halogen in donors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah]
comment: This term was obsoleted because EC obsoleted it, and there was no other evidence that this function exists.
is_obsolete: true

[Term]
id: GO:0052584
name: obsolete oxidoreductase activity, acting on halogen in donors, with NAD or NADP as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:mah]
comment: This term was obsoleted because EC obsoleted it, and there was no other evidence that this function exists.
is_obsolete: true

[Term]
id: GO:0052585
name: obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:ai]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0052586
name: obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:jl]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0052587
name: diacetyl reductase ((R)-acetoin forming) (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-acetoin + NAD+ = diacetyl + H+ + NADH. This reaction is catalyzed in the reverse direction." [RHEA:22900]
synonym: "(R)-acetoin dehydrogenase activity" RELATED [EC:1.1.1.303]
xref: EC:1.1.1.303
xref: KEGG_REACTION:R02855
xref: MetaCyc:RXN-11036
xref: RHEA:22900
is_a: GO:0019152 ! acetoin dehydrogenase (NAD+) activity

[Term]
id: GO:0052588
name: diacetyl reductase ((S)-acetoin forming) (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-acetoin + NAD+ = diacetyl + H+ + NADH. This reaction is catalyzed in the reverse direction." [RHEA:27286]
synonym: "(S)-acetoin dehydrogenase activity" RELATED [EC:1.1.1.304]
xref: EC:1.1.1.304
xref: KEGG_REACTION:R09078
xref: MetaCyc:RXN-11032
xref: RHEA:27286
is_a: GO:0019152 ! acetoin dehydrogenase (NAD+) activity

[Term]
id: GO:0052589
name: obsolete malate dehydrogenase (menaquinone) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol." [MetaCyc:RXNI-3]
comment: This term was obsoleted because it represents the same reaction as malate dehydrogenase (quinone) activity ; GO:0008924, with a different acceptor.
is_obsolete: true
replaced_by: GO:0008924

[Term]
id: GO:0052590
name: obsolete sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol." [MetaCyc:RXN0-5260]
comment: This term was obsoleted because it represents a specific substrate for glycerol-3-phosphate dehydrogenase (quinone) activity ; GO:0004368.
is_obsolete: true
replaced_by: GO:0004368

[Term]
id: GO:0052591
name: obsolete sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
comment: This term was obsoleted because it represents a specific substrate of glycerol-3-phosphate dehydrogenase (quinone) activity ; GO:0004368.
is_obsolete: true
replaced_by: GO:0004368

[Term]
id: GO:0052592
name: oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai]
synonym: "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor" EXACT []
xref: EC:1.17.7.-
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0052593
name: obsolete tryptamine:oxygen oxidoreductase (deaminating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of primary amine oxidase activity ; GO:0008131.
is_obsolete: true
replaced_by: GO:0008131

[Term]
id: GO:0052594
name: obsolete aminoacetone:oxygen oxidoreductase(deaminating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of primary amine oxidase activity ; GO:0008131.
is_obsolete: true
replaced_by: GO:0008131

[Term]
id: GO:0052595
name: aliphatic amine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEOXID-RXN]
synonym: "aliphatic-amine oxidase activity" EXACT []
synonym: "aliphatic-amine:oxygen oxidoreductase(deaminating) activity" EXACT []
xref: MetaCyc:AMINEOXID-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
is_a: GO:0030058 ! aliphatic amine dehydrogenase activity

[Term]
id: GO:0052596
name: obsolete phenethylamine:oxygen oxidoreductase (deaminating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of primary amine oxidase activity ; GO:0008131.
is_obsolete: true
replaced_by: GO:0008131

[Term]
id: GO:0052597
name: diamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH4+ + H2O2." [MetaCyc:RXN-9599]
synonym: "diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22]
xref: MetaCyc:RXN-9599
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052598
name: histamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4+." [RHEA:25625]
synonym: "1H-Imidazole-4-ethanamine oxidase activity" EXACT [KEGG_REACTION:R02150]
synonym: "1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity" EXACT [KEGG_REACTION:R02150]
synonym: "histamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22]
xref: KEGG_REACTION:R02150
xref: MetaCyc:RXN-9600
xref: Reactome:R-HSA-5696131 "AOC1 deaminates Hist"
xref: RHEA:25625
is_a: GO:0052597 ! diamine oxidase activity

[Term]
id: GO:0052599
name: obsolete methylputrescine oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+." [PMID:17283012, PMID:24287136]
comment: This term was obsoleted because it represents a specific substrate of diamine oxidase activity ; GO:0052597.
is_obsolete: true
replaced_by: GO:0052597

[Term]
id: GO:0052600
name: obsolete propane-1,3-diamine oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of diamine oxidase activity ; GO:0052597.
is_obsolete: true
replaced_by: GO:0052597

[Term]
id: GO:0052601
name: limonene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + limonene-1,2-epoxide. Can use either (4S)-limonene or (4R)-limonene as substrate. NADPH can act instead of NADH, although more slowly." [EC:1.14.13.107, PMID:8820855]
synonym: "(-)-limonene 1,2-monooxygenase activity" RELATED [EC:1.14.13.107]
synonym: "(-)-limonene,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.13.107]
synonym: "(S)-limonene 1,2-monooxygenase activity" NARROW []
synonym: "(S)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107]
xref: EC:1.14.13.107
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0052602
name: obsolete 4-chloronitrobenzene nitroreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O." [GOC:curators]
comment: The reason for obsoletion is that this term is equivalent to GO:0018546.
is_obsolete: true
replaced_by: GO:0018546

[Term]
id: GO:0052603
name: obsolete 1-chloro-4-nitrosobenzene nitroreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O." [MetaCyc:RXN-8834]
comment: The reason for obsoletion is that this term is out of scope for GO, it is a sub-reaction of GO:0018546.
is_obsolete: true
consider: GO:0018546

[Term]
id: GO:0052604
name: obsolete delta-tocopherol cyclase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol." [PMID:12213958]
comment: This term was obsoleted because it represent specific substrates of tocopherol cyclase activity ; GO:0009976.
is_obsolete: true
replaced_by: GO:0009976

[Term]
id: GO:0052605
name: obsolete gamma-tocopherol cyclase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol." [PMID:12213958]
comment: This term was obsoleted because it represent specific substrates of tocopherol cyclase activity ; GO:0009976.
is_obsolete: true
replaced_by: GO:0009976

[Term]
id: GO:0052606
name: obsolete chlorophyllide a oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O." [MetaCyc:RXN-7676]
comment: The reason for obsoletion is that the term is part of a multi-step reaction represented by GO:0010277 chlorophyllide a oxygenase [overall] activity.
synonym: "chlorophyll a oxygenase activity" EXACT []
is_obsolete: true
consider: GO:0010277

[Term]
id: GO:0052607
name: obsolete 7-hydroxy-chlorophyllide a oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O." [MetaCyc:RXN-7677]
comment: The reason for obsoletion is that the term is part of a multi-step reaction represented by GO:0010277 chlorophyllide a oxygenase [overall] activity.
synonym: "chlorophyll b synthetase activity" EXACT []
is_obsolete: true
consider: GO:0010277

[Term]
id: GO:0052608
name: echinenone 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8214]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: MetaCyc:RXN-8214
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052609
name: 4-ketotorulene 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8218]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: MetaCyc:RXN-8218
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052610
name: beta-cryptoxanthin hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O." [RHEA:30327]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: MetaCyc:RXN-8026
xref: RHEA:30327
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052611
name: beta-carotene 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O." [RHEA:30323]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: MetaCyc:RXN-8025
xref: RHEA:30323
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052612
name: adonirubin 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8187]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: MetaCyc:RXN-8187
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052613
name: canthaxanthin 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8186]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: MetaCyc:RXN-8186
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052614
name: uracil oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H+ + H2O + NAD+. Can also use thymine as a substrate." [PMID:20369853, PMID:20400551, RHEA:31587]
synonym: "pyrimidine oxygenase activity" BROAD [MetaCyc:RXN0-6444]
xref: EC:1.14.99.46
xref: MetaCyc:RXN0-6444
xref: RHEA:31587
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0052615
name: ent-kaurene oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]." [RHEA:32323]
xref: EC:1.14.14.86
xref: MetaCyc:1.14.13.78-RXN
xref: RHEA:32323
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052616
name: obsolete ent-kaur-16-en-19-ol oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al." [MetaCyc:RXN-5242]
comment: This term was obsoleted because it represents a subreaction of ent-kaurene oxidase activity ; GO:0052615.
is_obsolete: true
replaced_by: GO:0052615

[Term]
id: GO:0052617
name: obsolete ent-kaur-16-en-19-al oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate." [GOC:curators]
comment: This term was obsoleted because it represents a subreaction of ent-kaurene oxidase activity ; GO:0052615.
is_obsolete: true
replaced_by: GO:0052615

[Term]
id: GO:0052618
name: coenzyme F420-0:L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate." [MetaCyc:RXN-8080]
xref: EC:6.3.2.31
xref: MetaCyc:RXN-8080
xref: RHEA:30555
is_a: GO:0043773 ! coenzyme F420-0 gamma-glutamyl ligase activity

[Term]
id: GO:0052619
name: coenzyme F420-1:gamma-L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate." [MetaCyc:RXN-8081]
xref: EC:6.3.2.34
xref: MetaCyc:RXN-8081
xref: RHEA:30523
is_a: GO:0043773 ! coenzyme F420-0 gamma-glutamyl ligase activity

[Term]
id: GO:0052620
name: thymine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2." [RHEA:13469]
xref: MetaCyc:RXN-8646
xref: RHEA:13469
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0052621
name: diguanylate cyclase activity
namespace: molecular_function
alt_id: GO:0043789
def: "Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+." [EC:2.7.7.65, RHEA:24898]
synonym: "GTP:GTP guanylyltransferase activity" BROAD [EC:2.7.7.65]
xref: EC:2.7.7.65
xref: KEGG_REACTION:R08057
xref: MetaCyc:RXN0-5359
xref: RHEA:24898
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0052622
name: ATP/ADP dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate." [EC:2.5.1.112]
synonym: "2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity" NARROW []
synonym: "2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity" NARROW []
synonym: "2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity" NARROW []
synonym: "2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity" NARROW [KEGG_REACTION:R08052]
synonym: "adenylate dimethylallyltransferase (ADP/ATP-dependent) activity" EXACT []
synonym: "adenylate dimethylallyltransferase (ATP/ADP-dependent) activity" EXACT []
synonym: "adenylate isopentenyltransferase activity" BROAD []
synonym: "ADP dimethylallyltransferase activity" NARROW []
synonym: "ADP isopentenyltransferase activity" NARROW []
synonym: "ADP/ATP dimethylallyltransferase activity" EXACT []
synonym: "ATP dimethylallyltransferase activity" NARROW []
synonym: "ATP isopentenyltransferase activity" NARROW []
synonym: "cytokinin synthase activity" BROAD []
synonym: "dimethylallyl-diphosphate:ADP dimethylallyltransferase activity" NARROW []
synonym: "dimethylallyl-diphosphate:ATP dimethylallyltransferase activity" NARROW []
xref: EC:2.5.1.112
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0052623
name: obsolete ADP dimethylallyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate." [MetaCyc:RXN-4305]
comment: This term was obsoleted because it represents the same reaction as ATP dimethylallyltransferase activity ; GO:0052622.
synonym: "2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity" EXACT []
synonym: "ADP isopentenyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0052622

[Term]
id: GO:0052624
name: 2-phytyl-1,4-naphthoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: demethylphylloquinol + S-adenosyl-L-methionine = H+ + phylloquinol + S-adenosyl-L-homocysteine." [PMID:14617060, RHEA:40551]
synonym: "demethylphylloquinone methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity" EXACT []
synonym: "SA methyltransferase activity" BROAD []
synonym: "salicylate methyltransferase activity" BROAD []
synonym: "salicylic acid methyltransferase activity" BROAD []
xref: EC:2.1.1.329
xref: KEGG_REACTION:R06859
xref: MetaCyc:RXN-7569
xref: RHEA:40551
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0052625
name: N-(4-aminobenzoyl)-L-glutamate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP = N-(4-aminobenzoyl)-L-glutamate + AMP + diphosphate + H+." [MetaCyc:RXN-10884, PMID:19189963]
synonym: "4-aminobenzoate amino acid synthetase activity" BROAD []
synonym: "4-aminobenzoyl amino acid synthetase activity" EXACT []
synonym: "p-aminobenzoate amino acid synthetase activity" EXACT []
synonym: "p-aminobenzoyl amino acid synthetase activity" EXACT []
synonym: "pABA amino acid synthetase activity" EXACT []
xref: MetaCyc:RXN-10884
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052626
name: N-benzoyl-L-glutamate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + L-glutamate + ATP = N-benzoyl-L-glutamate + AMP + diphosphate + H+." [MetaCyc:RXN-10886, PMID:19189963]
synonym: "benzoate amino acid synthetase activity" BROAD []
synonym: "benzoyl amino acid synthetase activity" EXACT []
xref: MetaCyc:RXN-10886
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052627
name: N-vanillate-L-glutamate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: vanillate + L-glutamate + ATP = N-vanillate-L-glutamate + AMP + diphosphate + H+." [MetaCyc:RXN-10885, PMID:19189963]
synonym: "vanillate amino acid synthetase activity" BROAD []
xref: MetaCyc:RXN-10885
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052628
name: N-(4-hydroxybenzoyl)-L-glutamate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + L-glutamate + ATP = N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphate + H+." [MetaCyc:RXN-10887, PMID:19189963]
synonym: "4-hydroxybenzoate amino acid synthetase activity" BROAD []
synonym: "4-hydroxybenzoyl amino acid synthetase activity" EXACT []
synonym: "4HBA amino acid synthetase activity" EXACT []
synonym: "p-hydroxybenzoate amino acid synthetase activity" EXACT []
synonym: "p-hydroxybenzoyl amino acid synthetase activity" EXACT []
xref: MetaCyc:RXN-10887
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052629
name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019]
xref: EC:3.1.3.95
xref: MetaCyc:RXN-10958
xref: Reactome:R-HSA-1676065 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane"
xref: Reactome:R-HSA-1676105 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane"
xref: Reactome:R-HSA-1676203 "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane"
xref: Reactome:R-HSA-6809320 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane"
xref: Reactome:R-HSA-6809778 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1"
xref: Reactome:R-HSA-6809944 "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane"
xref: RHEA:39019
is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity

[Term]
id: GO:0052630
name: UDP-N-acetylgalactosamine diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine." [EC:2.7.7.83, RHEA:34363]
synonym: "N-acetylgalactosamine 1-phosphate uridylyltransferase" EXACT []
synonym: "N-acetylgalactosamine-1-phosphate uridyltransferase activity" EXACT []
synonym: "UDP-acetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "UDP-GalNAc pyrophosphorylase activity" EXACT []
synonym: "UDP-N-acetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "uridine diphosphoacetylgalactosamine phosphorylase activity" EXACT []
synonym: "uridine diphosphoacetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT []
synonym: "UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity" EXACT []
xref: EC:2.7.7.83
xref: RHEA:34363
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0052631
name: sphingolipid 8-(E/Z)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O or an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O. This results in the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid." [EC:1.14.19.29, PMID:17600137, PMID:9786850]
synonym: "8 fatty acid desaturase" EXACT [EC:1.14.19.29]
synonym: "8-sphingolipid desaturase" EXACT [EC:1.14.19.29]
synonym: "sphingolipid delta-8 desaturase activity" EXACT []
xref: EC:1.14.19.29
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0052633
name: obsolete isocitrate hydro-lyase (cis-aconitate-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cis-aconitate + H2O = isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw, MetaCyc:ACONITATEHYDR-RXN]
comment: This term was obsoleted because it represents a sub-reaction.
synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3]
synonym: "cis-aconitase activity" BROAD [EC:4.2.1.3]
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" BROAD [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase activity" BROAD [EC:4.2.1.3]
is_obsolete: true
replaced_by: GO:0003994

[Term]
id: GO:0052634
name: obsolete C-19 gibberellin 2-beta-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons." [GOC:kad, PMID:12509528]
comment: This term was obsoleted because it represents a specific substrate of gibberellin 2-beta-dioxygenase activity ; GO:0045543.
synonym: "(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT []
synonym: "C(19) gibberellin 2-oxidase activity" EXACT []
synonym: "C-19 GA 2-oxidase activity" EXACT []
synonym: "C-19 gibberellin 2-beta-hydroxylase activity" EXACT []
synonym: "C-19 gibberellin 2-oxidase activity" EXACT []
synonym: "C-19 gibberellin 2beta-dioxygenase activity" EXACT []
synonym: "C-19 gibberellin 2beta-hydroxylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0045543

[Term]
id: GO:0052635
name: obsolete C-20 gibberellin 2-beta-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons." [GOC:kad, PMID:12509528]
comment: This term was obsoleted because it represents a specific substrate of gibberellin 2-beta-dioxygenase activity ; GO:0045543.
synonym: "(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT []
synonym: "C(20) gibberellin 2-oxidase activity" EXACT []
synonym: "C-20 GA 2-oxidase activity" EXACT []
synonym: "C-20 gibberellin 2-beta-hydroxylase activity" EXACT []
synonym: "C-20 gibberellin 2-oxidase activity" EXACT []
synonym: "C-20 gibberellin 2beta-dioxygenase activity" EXACT []
synonym: "C-20 gibberellin 2beta-hydroxylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0045543

[Term]
id: GO:0052636
name: arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor)." [GOC:ai]
synonym: "arabinosyl transferase activity" EXACT []
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0052637
name: obsolete delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol." [GOC:ai, PMID:19682287]
comment: This term was obsoleted because it represents the same reaction as palmitoyl-[glycerolipid] 3-(E)-desaturase activity ; GO:0102654.
is_obsolete: true
replaced_by: GO:0102654

[Term]
id: GO:0052638
name: indole-3-butyrate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655, RHEA:62708]
synonym: "IBA-Glc synthetase activity" EXACT []
synonym: "IBA-glucose synthase activity" EXACT []
synonym: "IBAGlu synthase activity" EXACT []
synonym: "indol-3-ylbutyrylglucose synthase activity" EXACT []
synonym: "indole-3-butyric acid glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity" EXACT []
synonym: "UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity" EXACT []
synonym: "UDPG-indol-3-ylbutyryl glucosyl transferase activity" EXACT []
synonym: "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity" EXACT []
synonym: "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity" EXACT []
xref: MetaCyc:RXN-11655
xref: RHEA:62708
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052639
name: salicylic acid glucosyltransferase (ester-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659, RHEA:62316]
synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11659]
synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:SA glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
xref: MetaCyc:RXN-11659
xref: RHEA:62316
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052640
name: salicylic acid glucosyltransferase (glucoside-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658, RHEA:62312]
synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11658]
synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:SA glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
xref: MetaCyc:RXN-11658
xref: RHEA:62312
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052641
name: benzoic acid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP." [MetaCyc:RXN-11660]
synonym: "benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
synonym: "UDP:glucose:BA glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
synonym: "UDP:glucose:benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
synonym: "UDP:glucose:benzoic acid glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
xref: MetaCyc:RXN-11660
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052642
name: lysophosphatidic acid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol." [PMID:20045079, PMID:7966317]
synonym: "1-acyl-sn-glycerol 3-phosphatase activity" EXACT [EC:3.1.3.106]
synonym: "2-lysophosphatidate phosphatase activity" EXACT [EC:3.1.3.106]
synonym: "LPA phosphatase activity" EXACT []
synonym: "lysophosphatidate phosphatase activity" EXACT []
xref: EC:3.1.3.106
xref: MetaCyc:RXNQT-4375
xref: Reactome:R-HSA-8878654 "ACP6 hydrolyses MYS-LPA"
xref: RHEA:33155
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0052643
name: chlorophyllide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyllides, any chlorophyll lacking the terpenoid side chain such as phytyl or farnesyl." [PMID:7724548]
synonym: "chlorophyllide metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0052644
name: chlorophyllide a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyllide a, a chlorophyll lacking the terpenoid side chain, which is the functional parent of chlorophyll a." [PMID:7724548]
synonym: "chlorophyllide a metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0052643 ! chlorophyllide metabolic process

[Term]
id: GO:0052645
name: F420-0 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving F420-0 (5-O-{[(1S)-1-carboxyethoxy](hydroxy)phosphoryl}-1-deoxy-1-(8-hydroxy-2,4-dioxo-2H-pyrimido[4,5-b]quinolin-10(4H)-yl)-D-ribitol), the fragment of coenzyme F420 remaining after formal hydrolytic removal of all of the glutamate residues." [GOC:curators]
synonym: "coenzyme F420-0 metabolic process" EXACT [CHEBI:59532]
synonym: "coenzyme F420-0 metabolism" EXACT [CHEBI:59532]
synonym: "F(420)-0 metabolic process" EXACT [CHEBI:59532]
synonym: "F420-0 metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0052648 ! ribitol phosphate metabolic process

[Term]
id: GO:0052646
name: alditol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [PMID:30240188]
synonym: "alditol phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0052647
name: pentitol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentitol phosphates, any phosphorylated alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
synonym: "pentitol phosphate metabolism" EXACT []
is_a: GO:0052646 ! alditol phosphate metabolic process

[Term]
id: GO:0052648
name: ribitol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribitol phosphates, any phosphorylated form of ribitol, the pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732]
synonym: "ribitol phosphate metabolism" EXACT []
is_a: GO:0052647 ! pentitol phosphate metabolic process

[Term]
id: GO:0052649
name: coenzyme gamma-F420-2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme gamma-F420-2 (F420-2; coenzyme F420; N-{N-[O-(7,8-didemethyl-8-hydroxy-5-deazariboflavin phospho)-(S)-lactyl]-gamma-L-glutamyl}-L-glutamate), the amide obtained by formal condensation of the carboxylic acid group of F420-0 with the amino group of L-gamma-glutamyl-L-glutamic acid." [GOC:curators]
synonym: "coenzyme F420 metabolic process" EXACT [CHEBI:16848]
synonym: "coenzyme F420 metabolism" EXACT [CHEBI:16848]
synonym: "coenzyme gamma-F420-2 metabolism" EXACT []
synonym: "F420-2 metabolic process" EXACT [CHEBI:16848]
synonym: "F420-2 metabolism" EXACT [CHEBI:16848]
is_a: GO:0052648 ! ribitol phosphate metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0052650
name: all-trans-retinol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25033]
synonym: "all-trans retinal reductase activity" BROAD [EC:1.1.1.300]
synonym: "all-trans-retinol dehydrogenase activity" BROAD [EC:1.1.1.300]
synonym: "NADP(H)-dependent retinol dehydrogenase/reductase activity" RELATED [EC:1.1.1.300]
synonym: "NADP-retinol dehydrogenase activity" EXACT []
synonym: "retinol dehydrogenase [NADP+] activity" RELATED [EC:1.1.1.300]
synonym: "retinol dehydrogenase activity" BROAD []
synonym: "retinol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.300]
xref: EC:1.1.1.300
xref: KEGG_REACTION:R08379
xref: MetaCyc:RXN-10841
xref: Reactome:R-HSA-2464803 "RDH8 reduces atRAL to atROL"
xref: Reactome:R-HSA-2464822 "RDH12 reduces atRAL to atROL"
xref: Reactome:R-HSA-2465921 "11cRDH oxidises 11cROL to 11cRAL"
xref: Reactome:R-HSA-2465940 "atRAL is reduced to atROL"
xref: Reactome:R-HSA-2466861 "Defective RDH12 does not reduce atRAL to atROL"
xref: Reactome:R-HSA-5419165 "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL"
xref: Reactome:R-HSA-5615668 "AKR1C3 reduces atRAL to atROL"
xref: Reactome:R-HSA-5623643 "RDH13 reduces atRAL to atROL"
xref: Reactome:R-HSA-74872 "RDH10,11 oxidise 11cROL to 11cRAL"
xref: RHEA:25033
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity

[Term]
id: GO:0052651
name: monoacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [PMID:25290914]
synonym: "monoacylglycerol breakdown" EXACT []
synonym: "monoacylglycerol catabolism" EXACT []
synonym: "monoacylglycerol degradation" EXACT []
is_a: GO:0046462 ! monoacylglycerol metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process

[Term]
id: GO:0052652
name: cyclic purine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine." [PMID:23911318]
synonym: "cyclic purine nucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0052653
name: 3',5'-cyclic diguanylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3',5'-cyclic diguanylic acid, a cyclic purine dinucleotide in which the base groups are guanine." [GOC:curators]
synonym: "3',5'-cyclic diguanylic acid metabolism" EXACT []
synonym: "cdiGMP metabolic process" EXACT []
synonym: "cdiGMP metabolism" EXACT []
synonym: "cyclic diguanylate metabolic process" EXACT []
synonym: "cyclic diguanylate metabolism" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009190 ! cyclic nucleotide biosynthetic process
is_a: GO:0052652 ! cyclic purine nucleotide metabolic process

[Term]
id: GO:0052654
name: L-leucine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [RHEA:18321]
subset: goslim_chembl
synonym: "L-leucine aminotransferase activity" EXACT []
xref: KEGG_REACTION:R01090
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN
xref: RHEA:18321
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity

[Term]
id: GO:0052655
name: L-valine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [RHEA:24813]
subset: goslim_chembl
synonym: "L-valine aminotransferase activity" EXACT []
xref: KEGG_REACTION:R01214
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN
xref: RHEA:24813
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity

[Term]
id: GO:0052656
name: L-isoleucine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [RHEA:24801]
subset: goslim_chembl
synonym: "L-isoleucine aminotransferase activity" EXACT []
xref: KEGG_REACTION:R02199
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN
xref: RHEA:24801
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity

[Term]
id: GO:0052657
name: guanine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [RHEA:25424]
synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "GMP pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "GPRT" RELATED [EC:2.4.2.8]
synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "guanosine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "guanosine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "guanylate pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "guanylic pyrophosphorylase activity" RELATED [EC:2.4.2.8]
synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8]
xref: KEGG_REACTION:R01229
xref: MetaCyc:GUANPRIBOSYLTRAN-RXN
xref: RHEA:25424
is_a: GO:0106130 ! purine phosphoribosyltransferase activity

[Term]
id: GO:0052658
name: inositol-1,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [RHEA:19797]
synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" RELATED [EC:3.1.3.56]
synonym: "5PTase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56]
synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "InsP(3) 5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "InsP3 5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56]
synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED []
xref: KEGG_REACTION:R03394
xref: MetaCyc:3.1.3.56-RXN
xref: Reactome:R-HSA-1855174 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol"
xref: Reactome:R-HSA-1855222 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane"
xref: RHEA:19797
is_a: GO:0004445 ! inositol-polyphosphate 5-phosphatase activity

[Term]
id: GO:0052659
name: inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [RHEA:11392]
synonym: "D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED []
xref: KEGG_REACTION:R03430
xref: MetaCyc:RXN-8730
xref: Reactome:R-HSA-1855213 "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane"
xref: Reactome:R-HSA-1855218 "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol"
xref: RHEA:11392
is_a: GO:0004445 ! inositol-polyphosphate 5-phosphatase activity
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0052660
name: R-lactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+." [RHEA:23872]
synonym: "(R)-propane-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.77]
synonym: "D-lactaldehyde:propanediol oxidoreductase activity" RELATED [EC:1.1.1.77]
xref: KEGG_REACTION:R03080
xref: MetaCyc:RXN-8641
xref: RHEA:23872
is_a: GO:0008912 ! lactaldehyde reductase activity

[Term]
id: GO:0052661
name: S-lactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+." [RHEA:15933]
synonym: "(S)-propane-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.77]
synonym: "L-lactaldehyde:propanediol oxidoreductase activity" RELATED [EC:1.1.1.77]
xref: KEGG_REACTION:R02258
xref: MetaCyc:LACTALDREDUCT-RXN
xref: RHEA:15933
is_a: GO:0008912 ! lactaldehyde reductase activity

[Term]
id: GO:0052662
name: zeaxanthin epoxidase activity
namespace: molecular_function
alt_id: GO:0009540
alt_id: GO:0052663
def: "Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]." [RHEA:32443]
synonym: "antheraxanthin epoxidase activity" NARROW []
synonym: "zea-epoxidase activity" RELATED [EC:1.14.15.21]
synonym: "zeaxanthin epoxidase [overall] activity" RELATED []
xref: EC:1.14.15.21
xref: KEGG_REACTION:R10070
xref: MetaCyc:RXN-13193
xref: RHEA:32443
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052664
name: nitroalkane oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a primary nitroalkane + H2O + O2 = an aldehyde + H+ + H2O2 + nitrite; also converts secondary nitroalkanes to a ketone." [EC:1.7.3.1]
synonym: "NAO activity" RELATED [EC:1.7.3.1]
synonym: "nitroalkane reductase activity" RELATED [EC:1.7.3.1]
synonym: "nitroalkane:oxygen oxidoreductase activity" RELATED [EC:1.7.3.1]
xref: EC:1.7.3.1
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0052665
name: obsolete tRNA (uracil-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil." [PMID:25626150]
comment: This term was obsoleted because it was not precisely refined, and was replaced by tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity ; GO:0141101.
is_obsolete: true
consider: GO:0141101

[Term]
id: GO:0052666
name: obsolete tRNA (cytosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine." [GOC:hjd]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity" EXACT []
synonym: "transfer ribonucleate cytosine 2'-methyltransferase activity" EXACT []
synonym: "tRNA (cytosine 2')-methyltransferase activity" EXACT []
synonym: "tRNA cytosine 2'-methyltransferase activity" EXACT []
synonym: "tRNA cytosine-2'-O-methyltransferase activity" EXACT []
is_obsolete: true
consider: GO:0106059
consider: GO:0106340

[Term]
id: GO:0052667
name: obsolete phosphomethylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H+." [GOC:curators]
comment: This term was obsoleted because it represents a different substrate for phosphoethanolamine N-methyltransferase activity ; GO:0000234.
synonym: "N-methylethanolamine phosphate N-methyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0000234

[Term]
id: GO:0052668
name: CTP:farnesol kinase activity
namespace: molecular_function
alt_id: GO:0052669
def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+." [PMID:21395888, RHEA:51680]
synonym: "CTP:2-trans,-6-trans-farnesol kinase activity" EXACT []
synonym: "CTP:2-trans,-6-trans-farnesol phosphotransferase activity" EXACT []
synonym: "farnesol kinase activity" RELATED []
synonym: "farnesol phosphotransferase activity" EXACT []
synonym: "trans,trans-farnesol kinase activity" NARROW []
xref: MetaCyc:RXN-11625
xref: RHEA:51680
is_a: GO:0052673 ! prenol kinase activity

[Term]
id: GO:0052670
name: geraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate." [GOC:kd]
synonym: "geraniol phosphotransferase activity" EXACT []
is_a: GO:0052673 ! prenol kinase activity

[Term]
id: GO:0052671
name: geranylgeraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate." [GOC:kd]
synonym: "geranylgeraniol phosphotransferase activity" EXACT []
is_a: GO:0052673 ! prenol kinase activity

[Term]
id: GO:0052672
name: CTP:geranylgeraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E,10E)-geranylgeraniol + CTP = (2E,6E,10E)-geranylgeranyl phosphate + CDP + H+." [RHEA:63456]
synonym: "CTP:geranylgeraniol phosphotransferase activity" EXACT []
xref: MetaCyc:RXN-11629
xref: RHEA:63456
is_a: GO:0052671 ! geranylgeraniol kinase activity

[Term]
id: GO:0052673
name: prenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity." [GOC:ai, GOC:kd]
synonym: "prenol phosphotransferase activity" EXACT []
synonym: "prenyl alcohol kinase activity" EXACT []
synonym: "prenyl alcohol phosphotransferase activity" EXACT []
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0052674
name: ent-pimara-9(11),15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate." [RHEA:25544]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.31]
synonym: "PMD synthase activity" BROAD [EC:4.2.3.31]
xref: EC:4.2.3.31
xref: MetaCyc:RXN-9299
xref: RHEA:25544
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052675
name: 3-methylbutanal reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde." [RHEA:18525]
synonym: "3-methylbutanal reductase (NADP) activity" EXACT []
synonym: "3-methylbutanol:NADP oxidoreductase activity" EXACT []
synonym: "3-methylbutanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.265]
synonym: "3-methylbutyraldehyde reductase (NADP) activity" EXACT []
synonym: "isoamyl alcohol oxidase (NADP) activity" EXACT []
xref: KEGG_REACTION:R05686
xref: RHEA:18525
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity
is_a: GO:0046568 ! 3-methylbutanal reductase [NAD(P)H] activity

[Term]
id: GO:0052676
name: 3-methylbutanal reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde." [KEGG_REACTION:R05685, RHEA:18529]
synonym: "3-methylbutanal reductase (NAD) activity" EXACT []
synonym: "3-methylbutanol:NAD oxidoreductase activity" EXACT []
synonym: "3-methylbutanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.265]
synonym: "3-methylbutyraldehyde reductase (NAD) activity" EXACT []
synonym: "isoamyl alcohol oxidase (NAD) activity" EXACT []
xref: KEGG_REACTION:R05685
xref: RHEA:18529
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity
is_a: GO:0046568 ! 3-methylbutanal reductase [NAD(P)H] activity

[Term]
id: GO:0052677
name: obsolete D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as D-arabinitol dehydrogenase (NADP+) activity ; GO:0033709.
is_obsolete: true
replaced_by: GO:0033709

[Term]
id: GO:0052678
name: levopimaradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate." [RHEA:25548]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.32]
xref: EC:4.2.3.32
xref: KEGG_REACTION:R06302
xref: MetaCyc:RXN-8511
xref: RHEA:25548
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052679
name: terpentetriene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene." [RHEA:25617]
synonym: "terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity" EXACT systematic_synonym [EC:4.2.3.36]
xref: EC:4.2.3.36
xref: MetaCyc:RXN-9455
xref: RHEA:25617
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052680
name: epi-isozizaene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate." [RHEA:25992]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity" EXACT systematic_synonym [EC:4.2.3.37, KEGG_REACTION:R07830]
xref: EC:4.2.3.37
xref: KEGG_REACTION:R07830
xref: MetaCyc:RXN-9349
xref: RHEA:25992
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052681
name: alpha-bisabolene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate." [RHEA:25436]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.38]
synonym: "bisabolene synthase activity" BROAD [KEGG_REACTION:R08370]
xref: EC:4.2.3.38
xref: KEGG_REACTION:R08370
xref: MetaCyc:RXN-8550
xref: RHEA:25436
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052682
name: epi-cedrol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate." [RHEA:26115]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity" EXACT systematic_synonym [EC:4.2.3.39]
synonym: "8-epicedrol synthase activity" EXACT []
synonym: "epicedrol synthase activity" EXACT []
xref: EC:4.2.3.39
xref: KEGG_REACTION:R09140
xref: MetaCyc:RXN-10004
xref: RHEA:26115
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052683
name: (Z)-gamma-bisabolene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate." [RHEA:26081]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.40]
xref: EC:4.2.3.40
xref: MetaCyc:RXN-10005
xref: RHEA:26081
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052684
name: L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O." [MetaCyc:RXN0-2382]
synonym: "L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity" EXACT [GOC:bf]
synonym: "tryptophan synthase beta subunit activity" NARROW []
xref: EC:4.2.1.122
xref: KEGG_REACTION:R00674
xref: MetaCyc:RXN0-2382
xref: RHEA:26434
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0052685
name: obsolete perillic acid-CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA." [KEGG_REACTION:R06368]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "perillic acid:CoA ligase (ADP-forming) activity" EXACT []
synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731]
is_obsolete: true

[Term]
id: GO:0052686
name: perillic acid-CoA ligase (AMP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA." [KEGG_REACTION:R06368, PMID:24952578]
synonym: "perillic acid:CoA ligase (AMP-forming) activity" EXACT []
synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731]
xref: KEGG_REACTION:R06368
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0052687
name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG_REACTION:R06396]
synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737]
xref: KEGG_REACTION:R06396
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0052688
name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG_REACTION:R06515]
synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737]
xref: KEGG_REACTION:R06515
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0052689
name: carboxylic ester hydrolase activity
namespace: molecular_function
alt_id: GO:0004091
alt_id: GO:0004302
alt_id: GO:0004759
alt_id: GO:0016789
def: "Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]
subset: goslim_drosophila
synonym: "carboxylate esterase activity" RELATED []
synonym: "carboxylic esterase activity" RELATED []
synonym: "hydrolase activity acting on ester bonds" RELATED [EC:3.1.1.-]
xref: EC:3.1.1.-
xref: KEGG_REACTION:R00630
xref: Reactome:R-HSA-5693691 "CES1 trimer.CES2 hydrolyse COCN to BEG"
xref: Reactome:R-HSA-8937442 "CES3 hydrolyses CHEST to CHOL and LCFA(-)"
xref: Reactome:R-HSA-9749792 "CES1,CES2 hydrolyze ASA- to ST"
xref: UM-BBD_reactionID:r1025
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0052690
name: trichloro-p-hydroquinone reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [PMID:1459949, RHEA:56832, UM-BBD_reactionID:r0315]
synonym: "pentaerythritol tetranitrate reductase activity" RELATED [UM-BBD_enzymeID:e0028]
synonym: "tetrachlorohydroquinone reductive dehalogenase activity" RELATED [UM-BBD_enzymeID:e0251]
synonym: "trichlorohydroquinone reductive dehalogenase activity" EXACT []
synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028]
xref: RHEA:56832
xref: UM-BBD_reactionID:r0315
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0052691
name: UDP-arabinopyranose mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose." [EC:5.4.99.30, RHEA:28350]
synonym: "UDP-arabinopyranose pyranomutase activity" EXACT systematic_synonym [EC:5.4.99.30]
synonym: "UDP-L-Ara mutase activity" RELATED [EC:5.4.99.30]
synonym: "UDP-L-arabinopyranose furanomutase activity" RELATED [EC:5.4.99.30]
synonym: "UDP-L-arabinose mutase activity" RELATED [EC:5.4.99.30]
synonym: "uridine-diphosphate-L-arabinose mutase activity" RELATED [EC:5.4.99.30]
xref: EC:5.4.99.30
xref: MetaCyc:RXN-11552
xref: RHEA:28350
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0052692
name: raffinose alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose." [PMID:20739305, RHEA:70275]
synonym: "alkaline alpha-galactosidase activity" BROAD []
synonym: "raffinose galactohydrolase activity" BROAD []
synonym: "raffinose-specific alkaline alpha-galactosidase activity" EXACT [PMID:20739305]
xref: KEGG_REACTION:R01103
xref: MetaCyc:RXN-11502
xref: RHEA:70275
is_a: GO:0004557 ! alpha-galactosidase activity

[Term]
id: GO:0052693
name: epoxyqueuosine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant." [PMID:21502530, RHEA:32159]
xref: EC:1.17.99.6
xref: RHEA:32159
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0052694
name: jasmonoyl-isoleucine-12-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O." [MetaCyc:RXN-12421, PMID:21576464]
xref: MetaCyc:RXN-12421
xref: RHEA:54808
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052695
name: cellular glucuronidation
namespace: biological_process
def: "The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor." [GOC:BHF]
synonym: "cellular glucuronide biosynthesis" EXACT []
synonym: "cellular glucuronide biosynthetic process" EXACT []
synonym: "cellular glucuronoside biosynthesis" EXACT []
synonym: "cellular glucuronoside biosynthetic process" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process

[Term]
id: GO:0052696
name: flavonoid glucuronidation
namespace: biological_process
def: "The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor." [GOC:BHF, PMID:20056724]
synonym: "flavonoid glucuronide biosynthesis" EXACT []
synonym: "flavonoid glucuronide biosynthetic process" EXACT []
synonym: "flavonoid glucuronoside biosynthesis" EXACT []
synonym: "flavonoid glucuronoside biosynthetic process" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0052695 ! cellular glucuronidation

[Term]
id: GO:0052697
name: xenobiotic glucuronidation
namespace: biological_process
def: "The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion." [GOC:BHF, PMID:20056724]
synonym: "phase II metabolism" NARROW []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0052695 ! cellular glucuronidation

[Term]
id: GO:0052698
name: ergothioneine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine]
synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate metabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine metabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine metabolism" EXACT [CHEBI:4828]
synonym: "ergothioneine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0052701 ! modified histidine metabolic process

[Term]
id: GO:0052699
name: ergothioneine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine]
synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine anabolism" EXACT []
synonym: "2-mercaptoergothioneine trimethylbetaine biosynthesis" EXACT []
synonym: "2-mercaptoergothioneine trimethylbetaine biosynthetic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine formation" EXACT []
synonym: "2-mercaptoergothioneine trimethylbetaine synthesis" EXACT []
synonym: "ergothioneine anabolism" EXACT []
synonym: "ergothioneine biosynthesis" EXACT []
synonym: "ergothioneine formation" EXACT []
synonym: "ergothioneine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0052698 ! ergothioneine metabolic process
is_a: GO:0052703 ! modified histidine biosynthetic process

[Term]
id: GO:0052700
name: ergothioneine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine]
synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate catabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine breakdown" EXACT []
synonym: "2-mercaptoergothioneine trimethylbetaine catabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine catabolism" EXACT []
synonym: "2-mercaptoergothioneine trimethylbetaine degradation" EXACT []
synonym: "ergothioneine breakdown" EXACT []
synonym: "ergothioneine catabolism" EXACT []
synonym: "ergothioneine degradation" EXACT []
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0052698 ! ergothioneine metabolic process
is_a: GO:0052702 ! modified histidine catabolic process

[Term]
id: GO:0052701
name: modified histidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai]
synonym: "cellular histidine derivative metabolic process" EXACT []
synonym: "cellular histidine derivative metabolism" EXACT []
synonym: "cellular modified histidine metabolic process" EXACT []
synonym: "cellular modified histidine metabolism" EXACT []
synonym: "histidine derivative metabolic process" EXACT []
synonym: "modified histidine metabolism" EXACT []
is_a: GO:0006575 ! modified amino acid metabolic process

[Term]
id: GO:0052702
name: modified histidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai]
synonym: "cellular histidine derivative breakdown" EXACT []
synonym: "cellular histidine derivative catabolic process" EXACT []
synonym: "cellular histidine derivative catabolism" EXACT []
synonym: "cellular histidine derivative degradation" EXACT []
synonym: "cellular modified histidine breakdown" EXACT []
synonym: "cellular modified histidine catabolic process" EXACT []
synonym: "cellular modified histidine catabolism" EXACT []
synonym: "cellular modified histidine degradation" EXACT []
synonym: "histidine derivative catabolic process" EXACT []
synonym: "modified histidine catabolism" EXACT []
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0052701 ! modified histidine metabolic process

[Term]
id: GO:0052703
name: modified histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid within a cell." [GOC:ai]
synonym: "cellular histidine derivative anabolism" EXACT []
synonym: "cellular histidine derivative biosynthesis" EXACT []
synonym: "cellular histidine derivative biosynthetic process" EXACT []
synonym: "cellular histidine derivative formation" EXACT []
synonym: "cellular histidine derivative synthesis" EXACT []
synonym: "cellular modified histidine anabolism" EXACT []
synonym: "cellular modified histidine biosynthesis" EXACT []
synonym: "cellular modified histidine formation" EXACT []
synonym: "cellular modified histidine synthesis" EXACT []
synonym: "histidine derivative biosynthetic process" EXACT []
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0052701 ! modified histidine metabolic process

[Term]
id: GO:0052704
name: ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide
namespace: biological_process
def: "The pathway resulting in the formation of ergothioneine from histidine via a set of steps in which gamma-glutamyl-hercynylcysteine sulfoxide is formed as an intermediate." [PMID:4276459, PMID:5484456]
synonym: "ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" BROAD []
xref: Wikipedia:Ergothioneine
is_a: GO:0052699 ! ergothioneine biosynthetic process

[Term]
id: GO:0052705
name: obsolete methylhistidine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine." [GOC:curators]
comment: This term was obsoleted because it represents a substep of L-histidine N(alpha)-methyltransferase activity ; GO:0052706.
is_obsolete: true
replaced_by: GO:0052706

[Term]
id: GO:0052706
name: L-histidine N(alpha)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to L-histidine to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine)." [RHEA:38471]
synonym: "histidine methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "histidine N-methyltransferase activity" EXACT []
synonym: "histidine-alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity" EXACT [EC:2.1.1.44]
xref: EC:2.1.1.44
xref: KEGG_REACTION:R01169
xref: MetaCyc:RXN-14431
xref: RHEA:38471
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0052707
name: obsolete N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine
namespace: biological_process
def: "OBSOLETE. The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [GOC:curators]
comment: This term was obsoleted because it represents a substep of ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide ; GO:0052704.
synonym: "hercynine biosynthesis from histidine" EXACT []
synonym: "histidine betaine biosynthesis from histidine" EXACT []
synonym: "histidine catabolic process to hercynine" EXACT []
synonym: "histidine catabolism to hercynine" EXACT []
synonym: "histidine catabolism to N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" EXACT []
is_obsolete: true
replaced_by: GO:0052704

[Term]
id: GO:0052708
name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [GOC:curators]
synonym: "hercynine metabolic process" EXACT [CHEBI:15781]
synonym: "hercynine metabolism" EXACT [CHEBI:15781]
synonym: "histidine betaine metabolic process" EXACT [CHEBI:15781]
synonym: "histidine betaine metabolism" EXACT [CHEBI:15781]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolism" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0052709
name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [GOC:curators]
synonym: "hercynine anabolism" EXACT []
synonym: "hercynine biosynthesis" EXACT []
synonym: "hercynine biosynthetic process" EXACT []
synonym: "hercynine formation" EXACT []
synonym: "hercynine synthesis" EXACT []
synonym: "histidine betaine anabolism" EXACT []
synonym: "histidine betaine biosynthesis" EXACT []
synonym: "histidine betaine biosynthetic process" EXACT []
synonym: "histidine betaine formation" EXACT []
synonym: "histidine betaine synthesis" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine anabolism" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine formation" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine synthesis" EXACT []
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0052710
name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [GOC:curators]
synonym: "hercynine breakdown" EXACT []
synonym: "hercynine catabolic process" EXACT []
synonym: "hercynine catabolism" EXACT []
synonym: "hercynine degradation" EXACT []
synonym: "histidine betaine breakdown" EXACT []
synonym: "histidine betaine catabolic process" EXACT []
synonym: "histidine betaine catabolism" EXACT []
synonym: "histidine betaine degradation" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine breakdown" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine degradation" EXACT []
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0052711
name: obsolete ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
namespace: biological_process
def: "OBSOLETE. The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG_REACTION:R04878]
comment: The reason for obsoletion is that this term does not provide a useful distinction from its parent, GO:0052704 (because that trimethyl-His yada is present in both pathways)
synonym: "ergothioneine biosynthesis from hercynine" EXACT []
synonym: "ergothioneine biosynthesis from histidine betaine" EXACT []
synonym: "hercynine catabolism to ergothioneine" EXACT []
synonym: "histidine betaine catabolism to ergothioneine" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism to ergothioneine" EXACT []
is_obsolete: true

[Term]
id: GO:0052712
name: inositol phosphosphingolipid phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol." [GOC:ai]
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0052713
name: inositol phosphorylceramide phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol." [GOC:ai]
is_a: GO:0052712 ! inositol phosphosphingolipid phospholipase activity

[Term]
id: GO:0052714
name: mannosyl-inositol phosphorylceramide phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol." [GOC:ai]
is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity

[Term]
id: GO:0052715
name: mannosyl-diinositol phosphorylceramide phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol." [GOC:ai]
is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity

[Term]
id: GO:0052716
name: hydroquinone:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O." [EC:1.10.3.2]
synonym: "benzenediol:oxygen oxidoreductase activity" BROAD []
synonym: "laccase reaction" BROAD []
synonym: "p-diphenol:oxygen oxidoreductase activity" EXACT []
xref: EC:1.10.3.2
xref: KEGG_REACTION:R00083
xref: MetaCyc:LACCASE-RXN
xref: RHEA:11276
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0052717
name: tRNA-specific adenosine-34 deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule." [PMID:17875641, RHEA:43168]
synonym: "tRNA(Ala)-A34 deaminase activity" EXACT []
xref: EC:3.5.4.33
xref: RHEA:43168
is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity

[Term]
id: GO:0052718
name: tRNA-specific adenosine-34 deaminase complex
namespace: cellular_component
def: "A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human." [PMID:17875641]
synonym: "tRNA-A34 deaminase complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0052719
name: RNA-(apurinic or apyrimidinic site) endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends." [PMID:19401441]
synonym: "abasic endoribonuclease activity" EXACT []
synonym: "AP endoribonuclease activity" EXACT []
synonym: "apurinic endoribonuclease activity" NARROW []
synonym: "apyrimidinic endoribonuclease activity" NARROW []
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0052720
name: class II DNA-(apurinic or apyrimidinic site) endonuclease activity
namespace: molecular_function
alt_id: GO:0140079
def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:1698278]
comment: Class II AP endonuclease is a nuclease, but not Class I, III and IV.
synonym: "class II AP endonuclease activity" RELATED []
synonym: "class II DNA-(apurinic or apyrimidinic site) lyase activity" EXACT []
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0052721
name: obsolete regulation of apurinic/apyrimidinic endodeoxyribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of apurinic/apyrimidinic (AP) endodeoxyribonuclease activity, the hydrolysis of ester linkages immediately 5' to an AP (also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:19401441]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of abasic endodeoxyribonuclease activity" EXACT []
synonym: "regulation of AP endodeoxyribonuclease activity" EXACT []
synonym: "regulation of apurinic endodeoxyribonuclease activity" NARROW []
synonym: "regulation of apyrimidinic endodeoxyribonuclease activity" NARROW []
is_obsolete: true

[Term]
id: GO:0052722
name: fatty acid in-chain hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186]
xref: MetaCyc:RXN-12186
xref: RHEA:45084
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052723
name: inositol hexakisphosphate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP." [PMID:18981179, RHEA:37459]
xref: KEGG_REACTION:R05799
xref: MetaCyc:RXN-10972
xref: RHEA:37459
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0052724
name: inositol hexakisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [MetaCyc:RXN-10971, PMID:18981179]
xref: MetaCyc:RXN-10971
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0052725
name: inositol-1,3,4-trisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+." [RHEA:20940]
synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" BROAD []
synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" EXACT []
synonym: "inositol-trisphosphate 6-kinase activity" BROAD []
synonym: "ins(1,3,4)P(3) 6-kinase activity" RELATED []
synonym: "Ins(1,3,4)P3 6-kinase activity" RELATED []
synonym: "IP3 6-kinase activity" BROAD []
xref: KEGG_REACTION:R03429
xref: MetaCyc:2.7.1.133-RXN
xref: Reactome:R-HSA-1855197 "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol"
xref: Reactome:R-HSA-2267372 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4"
xref: RHEA:20940
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0052726
name: inositol-1,3,4-trisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+." [RHEA:13253]
synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" BROAD []
synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" EXACT []
synonym: "inositol-trisphosphate 5-kinase activity" BROAD []
synonym: "ins(1,3,4)P(3) 5-kinase activity" RELATED []
synonym: "IP3 5-kinase activity" BROAD []
xref: KEGG_REACTION:R03428
xref: MetaCyc:2.7.1.139-RXN
xref: Reactome:R-HSA-1855172 "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol"
xref: Reactome:R-HSA-994140 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4"
xref: RHEA:13253
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0052727
name: capsanthin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-antheraxanthin = all-trans-capsanthin." [RHEA:17373]
synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8]
synonym: "CCS" BROAD [EC:5.3.99.8]
synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8]
xref: MetaCyc:RXN-7947
xref: RHEA:17373
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0052728
name: capsorubin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-violaxanthin = all-trans-capsorubin." [RHEA:21752]
synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8]
synonym: "CCS" BROAD [EC:5.3.99.8]
synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8]
synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8]
xref: MetaCyc:RXN-7946
xref: RHEA:21752
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0052729
name: dimethylglycine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [RHEA:10072]
synonym: "ApDMT" RELATED [EC:2.1.1.157]
synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" RELATED [EC:2.1.1.157]
xref: EC:2.1.1.161
xref: KEGG_REACTION:R07244
xref: MetaCyc:RXN-9680
xref: RHEA:10072
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0052730
name: sarcosine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [RHEA:15453]
synonym: "S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity" RELATED [EC:2.1.1.157]
synonym: "SDMT" RELATED [EC:2.1.1.157]
xref: KEGG_REACTION:R07243
xref: MetaCyc:RXN-9679
xref: RHEA:15453
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0052731
name: phosphocholine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphocholine + H2O = choline + phosphate." [RHEA:10492]
synonym: "3X11A" RELATED [EC:3.1.3.75]
synonym: "PHOSPHO1" RELATED [EC:3.1.3.75]
synonym: "phosphoethanolamine phosphohydrolase activity" RELATED [EC:3.1.3.75]
xref: KEGG_REACTION:R06871
xref: MetaCyc:RXN-5647
xref: Reactome:R-HSA-1483159 "PCho is dephosphorylated to Cho by PHOSPHO1"
xref: RHEA:10492
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0052732
name: phosphoethanolamine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoethanolamine + H2O = ethanolamine + phosphate." [RHEA:16089]
synonym: "3X11A" RELATED [EC:3.1.3.75]
synonym: "PHOSPHO1" RELATED [EC:3.1.3.75]
synonym: "phosphoethanolamine phosphohydrolase activity" RELATED [EC:3.1.3.75]
xref: KEGG_REACTION:R06870
xref: MetaCyc:RXN-7948
xref: Reactome:R-HSA-1483096 "PETA is dephosphorylated to ETA by PHOSPHO1"
xref: RHEA:16089
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0052733
name: quinate 3-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+." [RHEA:18425]
synonym: "quinate:NADP 3-oxidoreductase activity" RELATED [EC:1.1.1.24]
synonym: "quinate:NADP(+) 3-oxidoreductase activity" RELATED [EC:1.1.1.24]
synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24]
xref: KEGG_REACTION:R06846
xref: RHEA:18425
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052734
name: shikimate 3-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+." [RHEA:17741]
synonym: "3-dehydroshikimate reductase activity" RELATED [EC:1.1.1.25]
synonym: "3-dehydroshikimic reductase activity" RELATED [EC:1.1.1.25]
synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25]
synonym: "DHS reductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate:NAD(P)(+) 3-oxidoreductase activity" RELATED [EC:1.1.1.25]
synonym: "shikimate:NAD(P)(+) oxidoreductase activity" BROAD [EC:1.1.1.25]
xref: KEGG_REACTION:R06847
xref: RHEA:17741
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052735
name: tRNA (cytidine-3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = an N3-methylcytidine in tRNA + H+ + S-adenosyl-L-homocysteine." [RHEA:60908]
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity" EXACT []
synonym: "transfer ribonucleate cytosine 3-methyltransferase activity" EXACT []
synonym: "tRNA (cytosine 3)-methyltransferase activity" EXACT []
synonym: "tRNA (cytosine-3-)-methyltransferase activity" EXACT []
synonym: "tRNA cytosine 3-methyltransferase activity" EXACT []
synonym: "tRNA cytosine-3-methyltransferase activity" EXACT []
xref: RHEA:60908
is_a: GO:0016427 ! tRNA (cytidine) methyltransferase activity

[Term]
id: GO:0052736
name: beta-glucanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds." [Wikipedia:Beta-glucan]
synonym: "beta-D-glucanase activity" EXACT []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0052737
name: pyruvate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2." [EC:1.2.5.1]
synonym: "pyruvate dehydrogenase activity" BROAD [EC:1.2.5.1]
synonym: "pyruvate:ubiquinone oxidoreductase activity" EXACT systematic_synonym [EC:1.2.5.1]
synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" RELATED [EC:1.2.5.1]
synonym: "pyruvic dehydrogenase activity" BROAD [EC:1.2.5.1]
xref: EC:1.2.5.1
xref: KEGG_REACTION:R03145
xref: MetaCyc:RXN-11496
xref: RHEA:27405
is_a: GO:0052738 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor

[Term]
id: GO:0052738
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [EC:1.2.5.-]
xref: EC:1.2.5.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0052739
name: phosphatidylserine 1-acylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG_REACTION:R04034]
synonym: "phosphatidylserine-specific phospholipase A1 activity" BROAD [EC:3.1.1.32]
xref: KEGG_REACTION:R04034
xref: Reactome:R-HSA-8869425 "PLA1A hydrolyses PS to 2-acyl LPS"
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0052740
name: obsolete 1-acyl-2-lysophosphatidylserine acylhydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as phospholipase A1 activity ; GO:0008970.
is_obsolete: true
replaced_by: GO:0008970

[Term]
id: GO:0052741
name: (R)-limonene 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:18957]
synonym: "(+)-limonene 6-monooxygenase activity" RELATED [EC:1.14.14.53]
synonym: "(+)-limonene-6-hydroxylase activity" RELATED [EC:1.14.14.53]
synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT systematic_synonym [EC:1.14.14.53]
xref: EC:1.14.14.53
xref: KEGG_REACTION:R06119
xref: MetaCyc:RXN-10746
xref: RHEA:18957
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0052742
name: phosphatidylinositol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]
synonym: "1-phosphatidylinositol kinase activity" EXACT []
xref: Reactome:R-HSA-1675773 "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane"
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0052743
name: inositol tetrakisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate." [GOC:ai]
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0052744
name: phosphatidylinositol monophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate." [GOC:ai]
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0052745
name: inositol phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0052746
name: obsolete inositol phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ISBN:0198506732]
comment: The reason for obsoletion is this is a single-step process.
synonym: "inositol and derivative phosphorylation" RELATED []
synonym: "myo-inositol and derivative phosphorylation" RELATED []
synonym: "myo-inositol phosphorylation" NARROW []
is_obsolete: true

[Term]
id: GO:0052747
name: obsolete sinapyl alcohol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+." [GOC:mengo_curators]
comment: This term has been obsoleted because it represents the same activity as cinnamyl-alcohol dehydrogenase activity ; GO:0045551.
synonym: "sinapyl-alcohol dehydrogenase activity" RELATED [EC:1.1.1.195]
synonym: "sinapyl-alcohol:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.1.1.195]
is_obsolete: true
replaced_by: GO:0045551

[Term]
id: GO:0052748
name: baicalin beta-D-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate." [GOC:mengo_curators, RHEA:28130]
synonym: "5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity" RELATED [EC:3.2.1.167]
synonym: "baicalinase activity" BROAD [EC:3.2.1.167]
xref: EC:3.2.1.167
xref: KEGG_REACTION:R09533
xref: MetaCyc:RXN-11760
xref: RHEA:28130
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0052749
name: glucose-6-phosphate dehydrogenase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420." [EC:1.1.98.2, GOC:mengo_curators, RHEA:27294]
synonym: "coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity" RELATED [EC:1.1.98.2]
synonym: "D-glucose-6-phosphate:F420 1-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.98.2]
synonym: "F420-dependent glucose-6-phosphate dehydrogenase activity" RELATED [EC:1.1.98.2]
xref: EC:1.1.98.2
xref: KEGG_REACTION:R09550
xref: MetaCyc:RXN-11283
xref: RHEA:27294
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0052750
name: reactive-black-5:hydrogen-peroxide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O." [KEGG_REACTION:R07612, MetaCyc:RXN-8666]
synonym: "versatile peroxidase activity" BROAD [EC:1.11.1.16]
xref: EC:1.11.1.16
xref: KEGG_REACTION:R07612
xref: MetaCyc:RXN-8666
xref: RHEA:22396
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0052751
name: GDP-mannose hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate." [PMID:16766526]
synonym: "GDP-mannose pyrophosphatase activity" RELATED [PMID:16766526]
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0052752
name: reduced coenzyme F420:heterodisulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH." [GOC:mengo_curators, PMID:9914308]
synonym: "coenzyme F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308]
synonym: "F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308]
synonym: "F420H2:heterodisulfide oxidoreductase activity" EXACT []
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0052753
name: propan-2-ol:coenzyme F420 oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420." [GOC:mengo_curators, PMID:15016352, PMID:1879431, PMID:8706724]
synonym: "F420-dependent propan-2-ol dehydrogenase activity" EXACT []
synonym: "F420-dependent secondary alcohol dehydrogenase activity" BROAD []
synonym: "isopropanol:coenzyme F420 oxidoreductase activity" EXACT []
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0052754
name: GTP:coenzyme F420 guanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate." [GOC:mengo_curators, MetaCyc:RXN-18273]
synonym: "coenzyme F390-G synthetase activity" EXACT []
synonym: "GTP:coenzyme F420 guanylyltransferase activity" EXACT []
xref: MetaCyc:RXN-18273
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0052755
name: reduced coenzyme F420:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone." [GOC:mengo_curators, PMID:10971593, PMID:8055920]
synonym: "F420H2-dependent quinone oxidoreductase activity" EXACT []
synonym: "F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity" EXACT []
synonym: "F420H2:quinone oxidoreductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0052756
name: obsolete chitobiose phosphorylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units." [GOC:mengo_curators, PMID:15274915, Wikipedia:chitobiose]
comment: This term was obsoleted because there is no evidence that this activity exists,
is_obsolete: true

[Term]
id: GO:0052757
name: chondroitin hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]." [GOC:mengo_curators, PMID:18390555]
synonym: "chondroitin endo-beta-galactosaminidase activity" EXACT [PMID:18390555]
is_a: GO:0033931 ! endogalactosaminidase activity

[Term]
id: GO:0052758
name: obsolete coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1065]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity" EXACT []
synonym: "TNP reductase activity" BROAD []
is_obsolete: true

[Term]
id: GO:0052759
name: obsolete coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, UM-BBD_reactionID:r1066]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0052760
name: obsolete coenzyme F420-dependent 2,4-dinitrophenol reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1071]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
synonym: "coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity" EXACT []
synonym: "DNP reductase activity" BROAD []
is_obsolete: true

[Term]
id: GO:0052761
name: exo-1,4-beta-D-glucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units." [EC:3.2.1.165, GOC:mengo_curators, MetaCyc:3.2.1.165-RXN]
synonym: "chitosan exo-1,4-beta-D-glucosaminidase activity" EXACT [KEGG_REACTION:R08715]
synonym: "chitosan glucosaminohydrolase activity" EXACT [KEGG_REACTION:R08715]
synonym: "exo-beta-D-glucosaminidase activity" RELATED [EC:3.2.1.165]
synonym: "exochitosanase activity" RELATED [EC:3.2.1.165]
xref: EC:3.2.1.165
xref: KEGG_REACTION:R08715
xref: MetaCyc:3.2.1.165-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0052762
name: gellan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)." [GOC:mengo_curators, MetaCyc:RXN-12269]
xref: EC:4.2.2.25
xref: MetaCyc:RXN-12269
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0052763
name: ulvan lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end." [GOC:mengo_curators, PMID:9468631]
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0052764
name: exo-oligoalginate lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [GOC:mengo_curators, PMID:20925655]
xref: EC:4.2.2.26
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0052765
name: reduced coenzyme F420 oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O." [GOC:mengo_curators, PMID:15340796]
synonym: "coenzyme F420H2 oxidase activity" EXACT []
synonym: "F420H2 oxidase activity" EXACT []
synonym: "F420H2:oxygen oxidoreductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0052766
name: mannoside alpha-1,4-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [GOC:mengo_curators, PMID:20081828]
synonym: "alpha-1,4-exomannosidase activity" BROAD []
synonym: "alpha-1,4-mannosidase activity" BROAD []
synonym: "mannoside alpha-1,4-exomannosidase activity" EXACT []
synonym: "mannoside exo-alpha-1,4-mannosidase activity" EXACT []
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0052767
name: mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081]
synonym: "1,6-alpha-mannosidase activity" BROAD []
synonym: "1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
synonym: "alpha-1,6-mannosidase activity" BROAD []
synonym: "alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0052768
name: mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081]
synonym: "1,3-alpha-mannosidase activity" BROAD []
synonym: "1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
synonym: "alpha-1,3-mannosidase activity" BROAD []
synonym: "alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0052769
name: beta-6-sulfate-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative." [GOC:mengo_curators, PMID:15716424]
synonym: "beta-6-SO3-N-acetylglucosaminidase activity" BROAD []
synonym: "exosulfoglycosidase activity" BROAD []
synonym: "sulfoglycosidase activity" BROAD []
synonym: "sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity" EXACT []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0052770
name: coenzyme F390-A hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911]
synonym: "8-hydroxyadenylylated-coenzyme F420 hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0052771
name: coenzyme F390-G hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911]
synonym: "8-hydroxyguanylylated-coenzyme F420 hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0052772
name: brefeldin A esterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone." [GOC:mengo_curators, PMID:10201402, PMID:8106385]
synonym: "BFA esterase activity" BROAD []
synonym: "brefeldin A hydrolase activity" EXACT []
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0052773
name: diacetylchitobiose deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine." [PMID:15136574, PMID:16232910, PMID:16736587, RHEA:62168]
comment: In this reaction N,N'-diacetylchitobiose is deacetylated at the non-reducing residue to produce 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). This is in contrast to EC:3.5.1.105 in which N,N'-diacetylchitobiose is deacetylated at the reducing residue to produce 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine (GlcNAc-GlcN). For the latter reaction, see GO:0036311.
synonym: "N,N'-diacetylchitobiose deacetylase (nonreducing end)" EXACT [MetaCyc:RXN-12543]
xref: EC:3.5.1.136
xref: MetaCyc:RXN-12543
xref: RHEA:62168
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0052774
name: glucosyl-N-acetylglucosamine glucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine." [GOC:mengo_curators, PMID:15136574, PMID:16232910, PMID:16736587]
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0052775
name: endo-1,3-alpha-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain." [GOC:mengo_curators, PMID:10439404]
synonym: "endo-(1,3)-alpha-L-rhamnosidase activity" EXACT []
synonym: "endo-(1->3)-alpha-L-rhamnosidase activity" EXACT []
synonym: "endorhamnosidase activity" BROAD []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0052776
name: chitin catabolic process to fructose 6-phosphate via glucosamine
namespace: biological_process
def: "The pathway resulting in the breakdown of chitin into fructose 6-phosphate, via glucosamine; acetate is also produced during the process." [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587]
synonym: "diacetylchitobiose catabolic process to glucosamine and acetate" EXACT []
xref: MetaCyc:PWY-6855
is_a: GO:0006032 ! chitin catabolic process
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0052777
name: diacetylchitobiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products." [PMID:22797760]
synonym: "diacetylchitobiose catabolism" EXACT [GOC:obol]
is_a: GO:0052778 ! diacetylchitobiose metabolic process
is_a: GO:0052782 ! amino disaccharide catabolic process

[Term]
id: GO:0052778
name: diacetylchitobiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diacetylchitobiose, the N,N'-diacetylated derivative of chitobiose." [PMID:22797760]
synonym: "diacetylchitobiose metabolism" EXACT [GOC:obol]
is_a: GO:0052779 ! amino disaccharide metabolic process

[Term]
id: GO:0052779
name: amino disaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [GOC:curators]
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0052780
name: chitobiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [GOC:curators]
is_a: GO:0052779 ! amino disaccharide metabolic process

[Term]
id: GO:0052781
name: chitobiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [GOC:curators]
is_a: GO:0052780 ! chitobiose metabolic process
is_a: GO:0052782 ! amino disaccharide catabolic process

[Term]
id: GO:0052782
name: amino disaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [GOC:curators]
is_a: GO:0052779 ! amino disaccharide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0052783
name: reuteran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [PMID:15256553, PMID:16000808]
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0052784
name: reuteran biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [GOC:mengo_curators, PMID:15256553, PMID:16000808]
synonym: "reuteransucrase-mediated reuteran biosynthesis" NARROW []
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0052783 ! reuteran metabolic process

[Term]
id: GO:0052785
name: cellulose catabolism by endo-processive cellulases
namespace: biological_process
def: "The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments." [GOC:mengo_curators, PMID:18035374]
synonym: "endo-processive cellulase activity" RELATED []
is_a: GO:0030245 ! cellulose catabolic process

[Term]
id: GO:0052786
name: alpha-linked polysaccharide catabolism to maltotriose
namespace: biological_process
def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose." [GOC:mengo_curators, PMID:7511484, PMID:9406414]
synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltotriose" EXACT []
synonym: "maltotriose-forming alpha-amylase activity" RELATED []
is_a: GO:0000272 ! polysaccharide catabolic process

[Term]
id: GO:0052787
name: alpha-linked polysaccharide catabolism to maltopentaose
namespace: biological_process
def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose." [GOC:mengo_curators, PMID:7511484, PMID:9406414]
synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltopentaose" EXACT []
synonym: "maltopentaose-forming alpha-amylase activity" RELATED []
is_a: GO:0000272 ! polysaccharide catabolic process

[Term]
id: GO:0052788
name: d-4,5 unsaturated beta-glucuronyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue." [GOC:mengo_curators, PMID:12729728]
synonym: "unsaturated beta-glucuronyl hydrolase activity" EXACT []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0052789
name: obsolete mannan 1,3-beta-mannosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose." [GOC:mengo_curators]
comment: This term was obsoleted because it corresponds to mannan endo-1,4-beta-mannosidase activity ; GO:0016985.
is_obsolete: true
replaced_by: GO:0016985

[Term]
id: GO:0052790
name: obsolete chitooligosaccharide deacetylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions." [GOC:mengo_curators, PMID:8421697, PMID:8986807]
comment: This term was obsoleted because there is no evidence that this specific activity exists.
is_obsolete: true

[Term]
id: GO:0052791
name: 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain." [GOC:mengo_curators, PMID:21247893]
synonym: "2-keto-3-deoxynononic acid sialidase activity" EXACT []
is_a: GO:0016997 ! alpha-sialidase activity

[Term]
id: GO:0052792
name: endo-xylogalacturonan hydrolase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position." [GOC:mengo_curators, PMID:10618200]
synonym: "endo-galacturonase activity" BROAD []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0052793
name: pectin acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin." [GOC:mengo_curators, PMID:9218776]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0052794
name: obsolete exo-alpha-(2->3)-sialidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates." [GOC:mengo_curators]
comment: This term was obsoleted because it represents a specific substrate of exo-alpha-sialidase activity ; GO:0004308.
synonym: "exo-alpha-(2,3)-sialidase activity" EXACT []
synonym: "exo-alpha-2,3-sialidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004308

[Term]
id: GO:0052795
name: obsolete exo-alpha-(2->6)-sialidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates." [GOC:mengo_curators]
comment: This term was obsoleted because it represents a specific substrate of exo-alpha-sialidase activity ; GO:0004308.
synonym: "exo-alpha-(2,6)-sialidase activity" EXACT []
synonym: "exo-alpha-2,6-sialidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004308

[Term]
id: GO:0052796
name: obsolete exo-alpha-(2->8)-sialidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates." [GOC:mengo_curators]
comment: This term was obsoleted because it represents a specific substrate of exo-alpha-sialidase activity ; GO:0004308.
synonym: "exo-alpha-(2,8)-sialidase activity" EXACT []
synonym: "exo-alpha-2,8-sialidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004308

[Term]
id: GO:0052797
name: 4-O-methyl-glucuronoyl methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]." [GOC:mengo_curators, PMID:16876163]
synonym: "glucuronoyl esterase activity" BROAD [PMID:16876163]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0052798
name: beta-galactoside alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor." [GOC:mengo_curators, PMID:7826016, PMID:8405811]
synonym: "trans-sialidase activity" BROAD []
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0052799
name: coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates." [GOC:mengo_curators, PMID:16387854, PMID:19039139]
synonym: "coenzyme F420-dependent nitroimidazole breakdown" EXACT []
synonym: "coenzyme F420-dependent nitroimidazole catabolism" EXACT []
synonym: "coenzyme F420-dependent nitroimidazole reduction" EXACT []
synonym: "coenzyme F420-dependent nitroreductase activity" RELATED []
is_a: GO:0052800 ! bicyclic nitroimidazole catabolic process

[Term]
id: GO:0052800
name: bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole." [PMID:16387854, PMID:19039139]
synonym: "bicyclic nitroimidazole breakdown" EXACT []
synonym: "bicyclic nitroimidazole catabolism" EXACT []
synonym: "bicyclic nitroimidazole degradation" EXACT []
is_a: GO:0052801 ! bicyclic nitroimidazole metabolic process
is_a: GO:0052804 ! nitroimidazole catabolic process

[Term]
id: GO:0052801
name: bicyclic nitroimidazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring." [PMID:16387854, PMID:19039139]
synonym: "bicyclic nitroimidazole metabolism" EXACT []
is_a: GO:0052802 ! nitroimidazole metabolic process

[Term]
id: GO:0052802
name: nitroimidazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139]
synonym: "nitroimidazole metabolism" EXACT []
is_a: GO:0052803 ! imidazole-containing compound metabolic process

[Term]
id: GO:0052803
name: imidazole-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [GOC:curators]
synonym: "imidazole metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0052804
name: nitroimidazole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139]
synonym: "nitroimidazole breakdown" EXACT []
synonym: "nitroimidazole catabolism" EXACT []
synonym: "nitroimidazole degradation" EXACT []
is_a: GO:0052805 ! imidazole-containing compound catabolic process

[Term]
id: GO:0052805
name: imidazole-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [GOC:curators]
synonym: "imidazole breakdown" EXACT []
synonym: "imidazole catabolism" EXACT []
synonym: "imidazole degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process

[Term]
id: GO:0052806
name: sulfite reductase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:16048999]
synonym: "coenzyme F420-dependent sulfite reductase activity" EXACT []
synonym: "coenzyme F420-sulfite reductase activity" EXACT []
synonym: "hydrogen-sulfide:coenzyme F420 oxidoreductase activity" EXACT []
synonym: "sulfite:reduced coenzyme F420 reductase activity" EXACT []
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0052807
name: aflatoxin reductase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:20807200]
synonym: "aflatoxin:coenzyme F420 oxidoreductase activity" EXACT []
synonym: "aflatoxin:reduced coenzyme F420 reductase activity" EXACT []
synonym: "coenzyme F420-aflatoxin reductase activity" EXACT []
synonym: "coenzyme F420-dependent aflatoxin reductase activity" EXACT []
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0052808
name: obsolete reduced coenzyme F420:NADP+ oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:11726492]
comment: This term was obsoleted because it represents the same activity as 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity ; GO:0102261.
synonym: "coenzyme F420-dependent NADP oxidoreductase activity" EXACT []
synonym: "coenzyme F420-dependent NADP reductase activity" EXACT []
synonym: "F420H2:NADP oxidoreductase activity" EXACT []
synonym: "F420H2:NADP+ oxidoreductase activity" EXACT []
synonym: "NADP+:F420 oxidoreductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0102261

[Term]
id: GO:0052809
name: acharan sulfate lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid." [GOC:mengo_curators, PMID:19566715]
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0052810
name: 1-phosphatidylinositol-5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + H+." [PMID:12270933, PMID:9660759, RHEA:44680]
synonym: "1-phosphatidylinositol 5-kinase activity" EXACT []
xref: Reactome:R-HSA-1675810 "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane"
xref: Reactome:R-HSA-1675866 "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane"
xref: RHEA:44680
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0052811
name: 1-phosphatidylinositol-3-phosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + H+." [PMID:9211928, PMID:9367159, PMID:9660759, RHEA:63688]
synonym: "phosphatidylinositol 3-phosphate 4-kinase activity" EXACT []
xref: MetaCyc:RXN-10957
xref: Reactome:R-HSA-1676145 "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane"
xref: RHEA:63688
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0052812
name: obsolete 1-phosphatidylinositol-3,4-bisphosphate 5-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+." [GOC:curators]
comment: This term was obsoleted because this reaction is not believed to be relevant physiologically.
synonym: "phosphatidylinositol-3,4-bisphosphate 5-kinase activity" EXACT []
is_obsolete: true
consider: GO:0016308

[Term]
id: GO:0052813
name: obsolete phosphatidylinositol bisphosphate kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate." [GOC:ai]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0052742

[Term]
id: GO:0052814
name: medium-chain fatty aldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a medium-chain fatty aldehyde + H2O + NAD+ = a medium chain fatty acid + 2 H+ + NADH." [RHEA:69763]
synonym: "medium-chain aliphatic aldehyde dehydrogenase activity" RELATED []
synonym: "medium-chain fatty aldehyde dehydrogenase activity" RELATED []
synonym: "medium-chain-aldehyde dehydrogenase activity" EXACT []
synonym: "medium-chain-aldehyde:NAD+ oxidoreductase activity" RELATED []
xref: RHEA:69763
is_a: GO:0102673 ! fatty aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0052815
name: medium-chain fatty acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a medium-chain fatty acyl-CoA + H2O = a medium-chain fatty acid + CoA + H+. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:68184]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "medium-chain acyl coenzyme A hydrolase activity" RELATED []
synonym: "medium-chain acyl-thioester hydrolase activity" RELATED []
synonym: "medium-chain hydrolase activity" RELATED []
synonym: "medium-chain-acyl-CoA hydrolase activity" RELATED []
xref: MetaCyc:3.1.2.19-RXN
xref: RHEA:68184
is_a: GO:0047617 ! fatty acyl-CoA hydrolase activity

[Term]
id: GO:0052816
name: long-chain fatty acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [RHEA:67680]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "long-chain acyl coenzyme A hydrolase activity" RELATED []
synonym: "long-chain acyl-thioester hydrolase activity" RELATED []
synonym: "long-chain hydrolase activity" RELATED []
synonym: "long-chain-acyl-CoA hydrolase activity" RELATED []
xref: RHEA:67680
is_a: GO:0047617 ! fatty acyl-CoA hydrolase activity

[Term]
id: GO:0052817
name: very long-chain fatty acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H+. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [RHEA:67072]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "very long-chain acyl coenzyme A hydrolase activity" RELATED []
synonym: "very long-chain acyl-thioester hydrolase activity" RELATED []
synonym: "very long-chain hydrolase activity" RELATED []
synonym: "very long-chain-acyl-CoA hydrolase activity" RELATED []
xref: RHEA:67072
is_a: GO:0047617 ! fatty acyl-CoA hydrolase activity

[Term]
id: GO:0052818
name: obsolete heteroglycan 3-alpha-mannosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP." [GOC:curators]
comment: This term was obsoleted because it represents the same reaction as heteroglycan alpha-mannosyltransferase activity ; GO:0047264.
synonym: "heteropolysaccharide 3-alpha-mannosyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047264

[Term]
id: GO:0052819
name: obsolete heteroglycan 2-alpha-mannosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP." [GOC:curators]
comment: This term was obsoleted because it represents the same reaction as heteroglycan alpha-mannosyltransferase activity ; GO:0047264.
synonym: "heteropolysaccharide 2-alpha-mannosyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0047264

[Term]
id: GO:0052820
name: DNA-1,N6-ethenoadenine N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar." [PMID:21960007]
synonym: "1,N(6)-ethenoadenine N-glycosylase activity" EXACT []
synonym: "1,N6-ethenoadenine glycosylase activity" EXACT []
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0052821
name: DNA-7-methyladenine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site." [GOC:jl, PMID:16468998]
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0052822
name: DNA-3-methylguanine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site." [GOC:elh, PMID:10872450, PMID:9224623]
is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity

[Term]
id: GO:0052823
name: 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H+." [RHEA:34191]
synonym: "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14]
synonym: "2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r1622]
xref: KEGG_REACTION:R06789
xref: MetaCyc:RXN-12070
xref: RHEA:34191
xref: UM-BBD_reactionID:r1622
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0052825
name: inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]
xref: Reactome:R-HSA-1855219 "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol"
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity

[Term]
id: GO:0052826
name: inositol hexakisphosphate 2-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [GOC:curators]
xref: Reactome:R-HSA-1855225 "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen"
is_a: GO:0004446 ! inositol-hexakisphosphate phosphatase activity

[Term]
id: GO:0052827
name: inositol pentakisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate." [GOC:bf]
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0052828
name: inositol-3,4-bisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate." [GOC:mah]
xref: Reactome:R-HSA-1855202 "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol"
xref: RHEA:43388
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity

[Term]
id: GO:0052829
name: inositol-1,3,4-trisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [GOC:ai]
xref: Reactome:R-HSA-1855232 "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol"
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0052830
name: inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate." [GOC:ai]
xref: Reactome:R-HSA-1855171 "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol"
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0052831
name: inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate." [GOC:ai]
xref: Reactome:R-HSA-1855159 "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol"
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0052832
name: inositol monophosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate." [RHEA:30739]
xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN
xref: Reactome:R-HSA-1855210 "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol"
xref: RHEA:30739
is_a: GO:0052834 ! inositol monophosphate phosphatase activity

[Term]
id: GO:0052833
name: inositol monophosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction:1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate." [RHEA:30735]
synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25]
synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD []
synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD []
xref: MetaCyc:RXN-10952
xref: Reactome:R-HSA-1855211 "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol"
xref: RHEA:30735
is_a: GO:0052834 ! inositol monophosphate phosphatase activity

[Term]
id: GO:0052834
name: inositol monophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
synonym: "inositol phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25]
synonym: "inositol-phosphate phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "L-myo-inositol-phosphate phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "myo-inositol monophosphatase activity" RELATED [EC:3.1.3.25]
synonym: "myo-inositol phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25]
synonym: "myo-inositol-phosphatase activity" RELATED [EC:3.1.3.25]
synonym: "myo-inositol-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.25]
xref: EC:3.1.3.25
xref: MetaCyc:RXN-10949
xref: RHEA:24056
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0052835
name: inositol-3,4,6-trisphosphate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+." [PMID:11909533, RHEA:70287]
synonym: "1D-myo-inositol-trisphosphate 1-kinase activity" BROAD []
synonym: "inositol 3,4,6-trisphosphate 1-kinase activity" EXACT []
synonym: "inositol-trisphosphate 1-kinase activity" BROAD []
synonym: "ins(3,4,6)P(3) 1-kinase activity" RELATED []
synonym: "Ins(3,4,6)P3 1-kinase activity" RELATED []
synonym: "IP3 1-kinase activity" BROAD []
xref: MetaCyc:RXN-10984
xref: Reactome:R-HSA-1855169 "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol"
xref: RHEA:70287
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0052836
name: inositol 5-diphosphate pentakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol pentakisphosphate = ADP + 5-triphospho-1D-myo-inositol pentakisphosphate." [PMID:11502751, PMID:18355727]
xref: Reactome:R-HSA-1855158 "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol"
xref: Reactome:R-HSA-1855224 "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus"
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0052837
name: thiazole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position." [GOC:curators]
synonym: "thiazole anabolism" EXACT []
synonym: "thiazole biosynthesis" EXACT []
synonym: "thiazole formation" EXACT []
synonym: "thiazole synthesis" EXACT []
is_a: GO:0018131 ! oxazole or thiazole biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0052838 ! thiazole metabolic process

[Term]
id: GO:0052838
name: thiazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position." [GOC:curators]
synonym: "thiazole metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046484 ! oxazole or thiazole metabolic process

[Term]
id: GO:0052839
name: diphosphoinositol tetrakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol tetrakisphosphate = ADP + bis(diphospho)-1D-myo-inositol trisphosphate." [PMID:10827188, PMID:11502751, PMID:18355727]
synonym: "inositol diphosphate tetrakisphosphate kinase activity" EXACT []
synonym: "PP-IP4 kinase activity" EXACT []
xref: Reactome:R-HSA-1855193 "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol"
xref: Reactome:R-HSA-1855230 "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus"
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0052840
name: inositol diphosphate tetrakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate." [PMID:10827188, PMID:11502751]
xref: MetaCyc:RXN-10963
xref: Reactome:R-HSA-1855166 "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol"
is_a: GO:0008486 ! diphosphoinositol-polyphosphate diphosphatase activity

[Term]
id: GO:0052841
name: inositol bisdiphosphate tetrakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate." [PMID:10827188, PMID:11502751]
xref: Reactome:R-HSA-1855165 "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol"
xref: Reactome:R-HSA-2023973 "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol"
is_a: GO:0008486 ! diphosphoinositol-polyphosphate diphosphatase activity

[Term]
id: GO:0052842
name: inositol diphosphate pentakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate." [PMID:10827188, PMID:11502751]
xref: Reactome:R-HSA-1855198 "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol"
xref: Reactome:R-HSA-2023971 "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol"
is_a: GO:0008486 ! diphosphoinositol-polyphosphate diphosphatase activity

[Term]
id: GO:0052843
name: inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
namespace: molecular_function
alt_id: GO:0101011
def: "Catalysis of the reaction: 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [PMID:10827188, PMID:11502751, PMID:26422458]
synonym: "inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity" EXACT []
synonym: "inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity" EXACT []
xref: MetaCyc:RXN-10977
is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity

[Term]
id: GO:0052844
name: inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [PMID:10827188, PMID:11502751]
xref: MetaCyc:RXN-10978
is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity

[Term]
id: GO:0052845
name: inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+." [PMID:10827188, PMID:11502751, RHEA:22384]
xref: KEGG_REACTION:R05779
xref: MetaCyc:RXN-10964
xref: RHEA:22384
is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity

[Term]
id: GO:0052846
name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
namespace: molecular_function
alt_id: GO:0101012
def: "Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+." [PMID:10827188, PMID:11502751, PMID:26422458]
synonym: "inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity" EXACT []
synonym: "inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity" EXACT []
xref: MetaCyc:RXN-10965
is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity

[Term]
id: GO:0052847
name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10975, PMID:10827188, PMID:11502751]
xref: MetaCyc:RXN-10975
is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity

[Term]
id: GO:0052848
name: inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+." [PMID:10827188, PMID:11502751, RHEA:56312]
xref: MetaCyc:RXN-10976
xref: RHEA:56312
is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity

[Term]
id: GO:0052849
name: curcumin reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 NADP+ + tetrahydrocurcumin = curcumin + 2 H+ + 2 NADPH." [RHEA:34815]
synonym: "NADPH-dependent curcumin reductase activity" EXACT []
xref: MetaCyc:RXN0-6676
xref: RHEA:34815
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052850
name: obsolete dihydrocurcumin (NADP+) reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dihydrocurcumin + NADP+ = curcumin + H+ + NADPH." [GOC:curators]
comment: This term was obsoleted because it is a subreaction of curcumin reductase (NADP+) activity ; GO:0052849.
synonym: "dihydrocurcumin reductase (NADPH) activity" EXACT []
synonym: "NADPH-dependent dihydrocurcumin reductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0052849

[Term]
id: GO:0052851
name: ferric-chelate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe3+-siderophore + NADP+ + H+ -> 2 Fe2+-siderophore + NADPH." [RHEA:28795]
synonym: "ferric chelate reductase activity" BROAD []
synonym: "ferric reductase, NADPH-dependent activity" EXACT []
synonym: "iron chelate reductase activity" BROAD []
xref: EC:1.16.1.9
xref: KEGG_REACTION:R09541
xref: MetaCyc:RXN0-6555
xref: Reactome:R-HSA-917811 "STEAP3,STEAP4 reduce Fe3+ to Fe2+"
xref: RHEA:28795
is_a: GO:0000293 ! ferric-chelate reductase activity
is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[Term]
id: GO:0052855
name: ADP-dependent NAD(P)H-hydrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + H+ + NAD(P)H + phosphate." [EC:4.2.1.136, PMID:21994945]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)" RELATED [EC:4.2.1.136]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.136]
synonym: "ADP-dependent H(4)NAD(P)OH dehydratase activity" EXACT []
synonym: "ADP-dependent H4NAD(P)OH dehydratase activity" EXACT []
xref: EC:4.2.1.136
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0052856
name: NAD(P)HX epimerase activity
namespace: molecular_function
def: "Catalysis of the reactions: (6R)-NADHX = (6S)-NADHX and (6R)-NADPHX = (6S)-NADPHX." [EC:5.1.99.6, PMID:21994945]
synonym: "NADHX epimerase activity" NARROW []
synonym: "NADPHX epimerase activity" NARROW []
xref: EC:5.1.99.6
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0052857
name: obsolete NADPHX epimerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX." [PMID:21994945]
comment: This term was obsoleted because it represents the same activity as NADHX epimerase activity ; GO:0052856.
xref: Reactome:R-HSA-6806966 "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX"
is_obsolete: true
replaced_by: GO:0052856

[Term]
id: GO:0052858
name: obsolete peptidyl-lysine acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine." [GOC:tb]
comment: The reason for obsoletion is that this term is equivalent to GO:0061733 peptide-lysine-N-acetyltransferase activity.
synonym: "acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity" EXACT []
synonym: "acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity" EXACT []
synonym: "peptidyl-lysine N(6)-acetyltransferase activity" EXACT []
synonym: "peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" EXACT []
synonym: "peptidyl-lysine N6-acetyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0061733

[Term]
id: GO:0052859
name: obsolete glucan endo-1,4-beta-glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans." [GOC:curators]
comment: This term was obsoleted because it was created by mistake; the reaction does not correspond to the EC number to which it was associated (EC:3.2.1.75; glucan endo-1,6-beta-glucosidase).
synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT []
synonym: "beta-1,4-glucan 4-glucanohydrolase activity" EXACT []
synonym: "beta-1,4-glucan hydrolase activity" EXACT []
synonym: "beta-1,4-glucanase activity" EXACT []
synonym: "beta-1->4-glucan hydrolase activity" EXACT []
synonym: "endo-(1,4)-beta-D-glucanase activity" EXACT []
synonym: "endo-(1->4)-beta-D-glucanase activity" EXACT []
synonym: "endo-1,4-beta-D-glucanase activity" EXACT []
synonym: "endo-1,4-beta-glucanase activity" EXACT []
synonym: "endo-beta-1,4-glucanase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046557

[Term]
id: GO:0052860
name: obsolete 2'-deoxymugineic-acid 3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25]
comment: This term was obsoleted because it represents the same activity as mugineic-acid 3-dioxygenase activity ; GO:0033761.
is_obsolete: true
replaced_by: GO:0033761

[Term]
id: GO:0052861
name: endo-1,3(4)-beta-glucanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3. Substrates include laminarin, lichenin and cereal D-glucans." [EC:3.2.1.6]
synonym: "1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity" NARROW [EC:3.2.1.6]
synonym: "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group" NARROW []
synonym: "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group" NARROW []
synonym: "laminaranase activity" RELATED [EC:3.2.1.6]
synonym: "laminarinase activity" RELATED [EC:3.2.1.6]
xref: EC:3.2.1.6
xref: MetaCyc:3.2.1.6-RXN
is_a: GO:0052736 ! beta-glucanase activity

[Term]
id: GO:0052862
name: obsolete glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group
namespace: molecular_function
def: "OBSOLETE. Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as endo-1,3(4)-beta-glucanase activity ; GO:0052861.
is_obsolete: true
replaced_by: GO:0052861

[Term]
id: GO:0052863
name: 1-deoxy-D-xylulose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [GOC:curators]
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolic process" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolism" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0052864
name: 1-deoxy-D-xylulose 5-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [GOC:curators]
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate breakdown" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolic process" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolism" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate degradation" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate breakdown" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate catabolism" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate degradation" EXACT []
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0052865
name: 1-deoxy-D-xylulose 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [GOC:curators]
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate anabolism" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthesis" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthetic process" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate formation" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate synthesis" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate anabolism" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate biosynthesis" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate formation" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate synthesis" EXACT []
is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0052866
name: phosphatidylinositol phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate." [GOC:ai]
synonym: "phosphoinositide phosphatase activity" EXACT []
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0052867
name: phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [GOC:curators]
synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD []
synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD []
synonym: "phosphatidylinositol-trisphosphatase activity" BROAD []
synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD []
synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD []
synonym: "triphosphoinositide phosphatase activity" BROAD []
synonym: "triphosphoinositide phosphomonoesterase activity" BROAD []
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity

[Term]
id: GO:0052868
name: protein-lysine lysyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine." [PMID:20729861]
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0052869
name: arachidonate omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. (5Z,8Z,11Z,14Z)-icosatetraenoic acid is also known as arachidonic acid is also and 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate as 20-HETE." [RHEA:39755]
synonym: "arachidonic acid hydroxylase activity" BROAD []
synonym: "arachidonic acid omega-hydroxylase activity" EXACT []
synonym: "arachidonic acid:oxygen 1-oxidoreductase activity" EXACT systematic_synonym []
xref: KEGG_REACTION:R07041
xref: MetaCyc:RXN-19677
xref: RHEA:39755
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052870
name: obsolete tocopherol omega-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003]
comment: This term was obsoleted because the reaction is not mentioned in the MetaCyc entry cited in the definition cross reference.
synonym: "tocopherol 13-hydroxylase activity" EXACT systematic_synonym []
is_obsolete: true
consider: GO:0052871

[Term]
id: GO:0052871
name: alpha-tocopherol omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:45108]
synonym: "alpha-tocopherol 13-hydroxylase activity" EXACT []
xref: MetaCyc:RXN-11003
xref: RHEA:45108
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052872
name: obsolete tocotrienol omega-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O ." [MetaCyc:RXN-11003]
comment: This term was obsoleted because the reaction is not mentioned in the MetaCyc entry cited in the definition cross reference.
synonym: "tocotrienol 13-hydroxylase activity" EXACT []
is_obsolete: true
consider: GO:0052871

[Term]
id: GO:0052873
name: FMN reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+." [RHEA:21624]
synonym: "NADPH dehydrogenase (FMN) activity" EXACT []
xref: EC:1.5.1.38
xref: KEGG_REACTION:R05706
xref: Reactome:R-HSA-1222399 "Iron is reduced and separates from mycobactin"
xref: RHEA:21624
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052874
name: FMN reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+." [RHEA:21620]
synonym: "NADH dehydrogenase (FMN) activity" EXACT []
synonym: "NADH-dependent FMN reductase activity" RELATED []
synonym: "NADH-FMN reductase activity" RELATED []
xref: EC:1.5.1.42
xref: KEGG_REACTION:R05705
xref: RHEA:21620
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052875
name: riboflavin reductase (NAD(P)H) activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH." [EC:1.5.1.41]
synonym: "flavin mononucleotide reductase activity" RELATED [EC:1.5.1.41]
synonym: "flavine mononucleotide reductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H-dependent FMN reductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H-FMN reductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H2 dehydrogenase (FMN) activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H2:FMN oxidoreductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H:FMN oxidoreductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H:riboflavin oxidoreductase activity" RELATED [EC:1.5.1.41]
synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.41]
synonym: "riboflavin mononucleotide reductase activity" RELATED [EC:1.5.1.41]
synonym: "riboflavin reductase (NADH) activity" NARROW []
synonym: "riboflavin reductase (NADPH) activity" NARROW []
synonym: "riboflavine mononucleotide reductase activity" RELATED [EC:1.5.1.41]
xref: EC:1.5.1.41
xref: KEGG_REACTION:R09750
xref: MetaCyc:RXN-12445
xref: RHEA:31455
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052876
name: methylamine dehydrogenase (amicyanin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]." [RHEA:30207]
synonym: "amine dehydrogenase" BROAD [EC:1.4.9.1]
synonym: "MADH activity" BROAD [EC:1.4.9.1]
synonym: "methylamine dehydrogenase activity" EXACT [EC:1.4.9.1]
synonym: "methylamine:amicyanin oxidoreductase (deaminating) activity" EXACT systematic_synonym []
synonym: "primary-amine dehydrogenase" BROAD [EC:1.4.9.1]
xref: EC:1.4.9.1
xref: KEGG_REACTION:R00606
xref: RHEA:30207
xref: UM-BBD_reactionID:r0075
is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor

[Term]
id: GO:0052877
name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor." [GOC:ai]
xref: EC:1.4.9.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0052878
name: linoleate 8R-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate." [RHEA:25395]
synonym: "5,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "5,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "7,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "7,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "linoleate diol synthase activity" RELATED [EC:1.13.11.60]
xref: EC:1.13.11.60
xref: KEGG_REACTION:R07061
xref: MetaCyc:RXN-12756
xref: RHEA:25395
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0052879
name: 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate." [RHEA:25399]
synonym: "(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity" RELATED [EC:5.4.4.6]
synonym: "8-hydroperoxide isomerase activity" BROAD [EC:5.4.4.6]
synonym: "linoleate diol synthase activity" RELATED [EC:5.4.4.6]
xref: EC:5.4.4.6
xref: KEGG_REACTION:R07062
xref: MetaCyc:RXN-12758
xref: RHEA:25399
is_a: GO:0050486 ! intramolecular hydroxytransferase activity

[Term]
id: GO:0052880
name: oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl]
xref: EC:1.10.9.-
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0052881
name: 4-hydroxyphenylacetate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O." [RHEA:30595]
synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.14.9]
synonym: "4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT systematic_synonym []
synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" BROAD [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate 3-hydroxylase (FAD) activity" RELATED [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate hydroxylase (FAD) activity" RELATED [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.14.9]
xref: EC:1.14.14.9
xref: MetaCyc:RXN-8505
xref: RHEA:30595
xref: UM-BBD_reactionID:r0301
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052882
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl]
xref: EC:1.20.9.-
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0052883
name: tyrosine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = NH4 + trans-4-coumarate." [RHEA:24906]
synonym: "L-tyrosine ammonia-lyase activity" RELATED [EC:4.3.1.23]
synonym: "TAL activity" BROAD [EC:4.3.1.23]
synonym: "tyrase activity" BROAD [EC:4.3.1.23]
xref: EC:4.3.1.23
xref: RHEA:24906
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0052884
name: all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate." [RHEA:31775]
synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64]
xref: Reactome:R-HSA-2453833 "RPE65 isomero-hydrolyses atREs to 11cROL"
xref: RHEA:31775
is_a: GO:0050253 ! retinyl-palmitate esterase activity

[Term]
id: GO:0052885
name: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid." [RHEA:31771]
synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity" RELATED [EC:3.1.1.64]
synonym: "all-trans-retinylester 11-cis isomerohydrolase activity" RELATED [EC:3.1.1.64]
synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64]
xref: KEGG_REACTION:R08388
xref: MetaCyc:RXN-12550
xref: RHEA:31771
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0052886
name: obsolete 9,9'-dicis-carotene:quinone oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol." [GOC:curators]
comment: This term was obsoleted because it represents a subreaction of 9,9'-di-cis-zeta-carotene desaturase activity ; GO:0016719.
is_obsolete: true
replaced_by: GO:0016719

[Term]
id: GO:0052887
name: obsolete 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol." [GOC:curators]
comment: This term was obsoleted because it represents a subreaction of 9,9'-di-cis-zeta-carotene desaturase activity ; GO:0016719.
is_obsolete: true
replaced_by: GO:0016719

[Term]
id: GO:0052888
name: obsolete dihydroorotate oxidase (fumarate) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [GOC:curators]
comment: EC has determined that this reaction in fact does not exist and have withdrawn EC:1.3.3.1. Note: If fumarate is not shown to be involved, you may want to consider GO:0004152, dihydroorotate dehydrogenase activity (parent term); if the reaction involves fumarate, then use GO:0052888 dihydroorotate oxidase (fumarate) activity.
synonym: "DHOD activity" BROAD []
synonym: "DHOdase activity" BROAD []
synonym: "DHodehase activity" BROAD []
synonym: "dihydoorotic acid dehydrogenase activity" BROAD []
synonym: "dihydroorotate dehydrogenase activity" BROAD []
synonym: "dihydroorotate oxidase (fumarate) activity" EXACT []
synonym: "dihydroorotate oxidase activity" BROAD []
is_obsolete: true

[Term]
id: GO:0052889
name: 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene
namespace: biological_process
def: "The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene." [MetaCyc:PWY-6475]
synonym: "7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene" EXACT []
synonym: "9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene" EXACT []
xref: MetaCyc:PWY-6475
is_a: GO:0016119 ! carotene metabolic process

[Term]
id: GO:0052890
name: oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin." [EC:1.3.8.-]
xref: EC:1.3.8.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0052891
name: aliphatic (S)-hydroxynitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide." [PMID:15299689]
synonym: "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity" BROAD [EC:4.1.2.47]
synonym: "(S)-cyanohydrin producing hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-oxynitrilase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-selective hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
xref: MetaCyc:RXN-11731
is_a: GO:0047606 ! (S)-hydroxynitrile lyase activity

[Term]
id: GO:0052892
name: aromatic (S)-hydroxynitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide." [RHEA:54660]
xref: KEGG_REACTION:R09359
xref: MetaCyc:RXN-11732
xref: RHEA:54660
is_a: GO:0047606 ! (S)-hydroxynitrile lyase activity

[Term]
id: GO:0052893
name: obsolete N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of spermine oxidase (propane-1,3-diamine-forming) activity ; GO:0052900.
is_obsolete: true
replaced_by: GO:0052900

[Term]
id: GO:0052894
name: obsolete norspermine:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of spermine oxidase activity ; GO:0052901.
is_obsolete: true
replaced_by: GO:0052901

[Term]
id: GO:0052895
name: obsolete N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of spermine oxidase activity ; GO:0052901.
is_obsolete: true
replaced_by: GO:0052901

[Term]
id: GO:0052896
name: obsolete spermidine oxidase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + O2 + spermidine = 1,3-diaminopropane + 4-aminobutanal + H2O2." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of spermine oxidase (propane-1,3-diamine-forming) activity ; GO:0052900.
is_obsolete: true
replaced_by: GO:0052900

[Term]
id: GO:0052897
name: N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2. Also active with N(1)-acetylspermine, weak activity with N(1),N(12)- diacetylspermine." [EC:1.5.3.15, RHEA:25972]
synonym: "N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.15]
xref: EC:1.5.3.15
xref: KEGG_REACTION:R09075
xref: MetaCyc:RXN-10463
xref: RHEA:25972
is_a: GO:0046592 ! polyamine oxidase activity

[Term]
id: GO:0052898
name: obsolete N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2." [GOC:curators]
comment: The reason for the obsoletion is because there is no evidence for the reaction. RHEA:25864 used as the definition has been determined to not exit.
is_obsolete: true

[Term]
id: GO:0052899
name: obsolete N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity ; GO:0052903.
is_obsolete: true
replaced_by: GO:0052903

[Term]
id: GO:0052900
name: spermine oxidase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + spermine = 1,3-diaminopropane + H2O2 + N-(3-aminopropyl)-4-aminobutanal. Weak activity on N(1)-acetylspermine and spermine." [EC:1.5.3.14, RHEA:25824]
synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14]
xref: EC:1.5.3.14
xref: MetaCyc:RXN-6421
xref: RHEA:25824
is_a: GO:0046592 ! polyamine oxidase activity

[Term]
id: GO:0052901
name: spermine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine. Weak activity with N(1)-acetylspermine. The Arabidopsis thaliana enzyme converts norspermine to norspermidine." [EC:1.5.3.16, RHEA:25804]
synonym: "spermine:oxygen oxidoreductase (spermidine-forming) activity" BROAD [EC:1.5.3.16]
xref: EC:1.5.3.16
xref: KEGG_REACTION:R09076
xref: MetaCyc:RXN-9015
xref: Reactome:R-HSA-141341 "SMOX-3 oxidises SPN to SPM"
xref: RHEA:25804
is_a: GO:0046592 ! polyamine oxidase activity

[Term]
id: GO:0052902
name: obsolete spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine." [GOC:curators]
comment: This term was obsoleted because it represents a specific activity of spermine oxidase activity ; GO:0052901.
is_obsolete: true
replaced_by: GO:0052901

[Term]
id: GO:0052903
name: N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine. Also converts N(1)-acetylspermidine to putrescine." [EC:1.5.3.13]
synonym: "https://github.com/geneontology/go-ontology/issues/28070" NARROW []
synonym: "N(1)-acetylpolyamine oxidase activity" BROAD []
synonym: "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity" NARROW [EC:1.5.3.13]
synonym: "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity" NARROW [EC:1.5.3.13]
xref: EC:1.5.3.13
xref: KEGG_REACTION:R03899
xref: MetaCyc:RXN-12090
is_a: GO:0046592 ! polyamine oxidase activity

[Term]
id: GO:0052904
name: obsolete N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity ; GO:0052903.
xref: Reactome:R-HSA-141348 "PAO:FAD oxidises NASPM to PTCN"
xref: Reactome:R-HSA-141351 "PAOX:FAD oxidises NASPN to SPM"
is_obsolete: true
replaced_by: GO:0052903

[Term]
id: GO:0052905
name: tRNA (guanosine(9)-N1)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine9 in tRNA + S-adenosyl-L-methionine = H+ + N1-methylguanosine9 in tRNA + S-adenosyl-L-homocysteine." [RHEA:43156]
synonym: "tRNA (guanine(9)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA (guanine-N(1)-)-methyltransferase activity" RELATED [EC:2.1.1.221]
synonym: "tRNA (guanosine(9)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA (guanosine(9)-N1-)-methyltransferase activity" EXACT []
synonym: "tRNA m(1)G(9) Mtase activity" RELATED [EC:2.1.1.221]
synonym: "tRNA m(1)G(9)-methyltransferase activity" RELATED [EC:2.1.1.221]
synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity" RELATED [EC:2.1.1.221]
synonym: "tRNA(m(1)G(9)/m(1)A(9))Mtase activity" RELATED [EC:2.1.1.221]
xref: EC:2.1.1.221
xref: MetaCyc:RXN-12459
xref: Reactome:R-HSA-6786621 "TRMT10A methylates guanosine-9 in tRNA"
xref: Reactome:R-HSA-6787591 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9"
xref: RHEA:43156
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0052906
name: tRNA (guanine(37)-N1)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.228]
synonym: "transfer RNA (m(1)G(37)) methyltransferase activity" RELATED [EC:2.1.1.228]
synonym: "tRNA (guanine(37)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA (guanosine(37)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA (guanosine(37)-N1-)-methyltransferase activity" EXACT []
synonym: "tRNA (m(1)G(37)) methyltransferase activity" RELATED [EC:2.1.1.228]
synonym: "tRNA-(N(1)G37) methyltransferase activity" RELATED [EC:2.1.1.228]
xref: EC:2.1.1.228
xref: MetaCyc:RXN-12458
xref: Reactome:R-HSA-6782859 "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)"
xref: RHEA:36899
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0052907
name: 23S rRNA (adenine(1618)-N(6))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA." [RHEA:16497]
synonym: "M(6)A(1618) activity" BROAD [EC:2.1.1.181]
synonym: "rRNA large subunit methyltransferase F activity" RELATED [EC:2.1.1.181]
xref: EC:2.1.1.181
xref: KEGG_REACTION:R07232
xref: MetaCyc:RXN-11596
xref: RHEA:16497
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity

[Term]
id: GO:0052908
name: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA." [RHEA:19609]
synonym: "S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity" RELATED [EC:2.1.1.182]
xref: EC:2.1.1.182
xref: MetaCyc:RXN-11633
xref: RHEA:19609
is_a: GO:0000179 ! rRNA (adenine-N6,N6-)-dimethyltransferase activity

[Term]
id: GO:0052909
name: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA." [RHEA:42780]
synonym: "M(6)(2)A dimethylase activity" BROAD [EC:2.1.1.183]
xref: EC:2.1.1.183
xref: MetaCyc:RXN-11634
xref: RHEA:42780
is_a: GO:0000179 ! rRNA (adenine-N6,N6-)-dimethyltransferase activity

[Term]
id: GO:0052910
name: 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA." [RHEA:42784]
synonym: "ermC 23S rRNA methyltransferase activity" RELATED [EC:2.1.1.184]
synonym: "rRNA methyltransferase ermC' activity" RELATED [EC:2.1.1.184]
synonym: "rRNA:m(6)A methyltransferase ermC' activity" RELATED [EC:2.1.1.184]
xref: EC:2.1.1.184
xref: MetaCyc:RXN-11597
xref: RHEA:42784
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity

[Term]
id: GO:0052911
name: 23S rRNA (guanine(745)-N(1))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.187]
synonym: "23S rRNA m(1)G(745) methyltransferase activity" RELATED [EC:2.1.1.187]
synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" BROAD [EC:2.1.1.187]
synonym: "ribosomal RNA(m(1)G)-methylase activity" BROAD [EC:2.1.1.187]
synonym: "rlmA(I) methyltransferase activity" BROAD [EC:2.1.1.187]
synonym: "rRNA(m(1)G)methylase activity" BROAD [EC:2.1.1.187]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" BROAD [EC:2.1.1.187]
xref: EC:2.1.1.187
xref: MetaCyc:RXN-11573
xref: RHEA:42900
is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity

[Term]
id: GO:0052912
name: 23S rRNA (guanine(748)-N(1))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.188]
synonym: "23S rRNA m(1)G(748) methyltransferase activity" BROAD [EC:2.1.1.188]
xref: EC:2.1.1.188
xref: MetaCyc:RXN-11599
xref: RHEA:42904
is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity

[Term]
id: GO:0052913
name: 16S rRNA (guanine(966)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.171]
xref: EC:2.1.1.171
xref: MetaCyc:RXN0-6515
xref: RHEA:23548
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052914
name: 16S rRNA (guanine(1207)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.172]
synonym: "M(2)G1207 methyltransferase activity" RELATED [EC:2.1.1.172]
xref: EC:2.1.1.172
xref: MetaCyc:RXN-11576
xref: RHEA:42736
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052915
name: 23S rRNA (guanine(2445)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.173]
xref: EC:2.1.1.173
xref: MetaCyc:RXN-11574
xref: RHEA:42740
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052916
name: 23S rRNA (guanine(1835)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.174]
xref: EC:2.1.1.174
xref: MetaCyc:RXN-11635
xref: RHEA:42744
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052917
name: dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase
namespace: molecular_function
alt_id: GO:0052824
def: "Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol." [PMID:10336995, RHEA:29535]
synonym: "dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.260]
synonym: "dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" EXACT [EC:2.4.1.260]
synonym: "dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.260
xref: KEGG_REACTION:R06260
xref: MetaCyc:RXN-5468
xref: RHEA:29535
is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity

[Term]
id: GO:0052918
name: dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.261, RHEA:29539]
xref: EC:2.4.1.261
xref: KEGG_REACTION:R06261
xref: MetaCyc:RXN-5469
xref: RHEA:29539
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity

[Term]
id: GO:0052919
name: aliphatic (R)-hydroxynitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide." [EC:4.1.2.46]
synonym: "(R)-HNL activity" BROAD [EC:4.1.2.46]
synonym: "(R)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.46]
synonym: "(R)-oxynitrilase activity" BROAD [EC:4.1.2.46]
xref: EC:4.1.2.46
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0052920
name: obsolete (2R)-2-hydroxy-2-methylbutanenitrile lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide." [EC:4.1.2.46]
comment: This term was obsoleted because it represents a specific substrate of aliphatic (R)-hydroxynitrile lyase activity ; GO:0052919.
is_obsolete: true
replaced_by: GO:0052919

[Term]
id: GO:0052921
name: obsolete acetone-cyanohydrin acetone-lyase (cyanide-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone." [KEGG_REACTION:R01553, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN]
comment: This term was obsoleted because it represents a specific substrate of aliphatic (R)-hydroxynitrile lyase activity ; GO:0052919.
is_obsolete: true
replaced_by: GO:0052919

[Term]
id: GO:0052922
name: hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate." [RHEA:27555]
synonym: "(all-E) hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82]
synonym: "(all-trans)-hexaprenyl-diphosphate synthase activity" BROAD [EC:2.5.1.82]
synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82]
synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.82]
xref: EC:2.5.1.82
xref: KEGG_REACTION:R09246
xref: MetaCyc:RXN-11485
xref: RHEA:27555
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0052923
name: all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
namespace: molecular_function
alt_id: GO:0050347
def: "Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate." [RHEA:27563]
synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" RELATED []
synonym: "all-trans-nonaprenyl-diphosphate synthase activity" RELATED []
synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.84]
synonym: "nonaprenyl pyrophosphate synthetase activity" RELATED []
synonym: "polyprenylpyrophosphate synthetase activity" RELATED []
synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.84]
synonym: "solanesyl pyrophosphate synthetase activity" RELATED []
synonym: "solanesyl-diphosphate synthase activity" RELATED []
synonym: "solPP synthase activity" BROAD [EC:2.5.1.84]
synonym: "SPP synthase activity" BROAD [EC:2.5.1.84]
synonym: "SPP-synthase activity" BROAD [EC:2.5.1.84]
synonym: "terpenoidallyltransferase activity" RELATED []
synonym: "terpenyl pyrophosphate synthetase activity" RELATED []
synonym: "trans-octaprenyltranstransferase activity" RELATED []
synonym: "trans-prenyltransferase activity" RELATED []
xref: EC:2.5.1.84
xref: KEGG_REACTION:R07267
xref: KEGG_REACTION:R09250
xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN
xref: RHEA:27563
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0052924
name: all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate." [RHEA:27594]
synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.85]
synonym: "solanesyl diphosphate synthase activity" BROAD [EC:2.5.1.85]
synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.85]
xref: EC:2.5.1.85
xref: KEGG_REACTION:R09251
xref: MetaCyc:RXN-11486
xref: RHEA:27594
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0052925
name: dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [RHEA:29527]
synonym: "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" RELATED [EC:2.4.1.258]
synonym: "man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity" RELATED [EC:2.4.1.258]
xref: EC:2.4.1.258
xref: KEGG_REACTION:R06258
xref: MetaCyc:RXN-5466
xref: RHEA:29527
is_a: GO:0000033 ! alpha-1,3-mannosyltransferase activity

[Term]
id: GO:0052926
name: dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.259, RHEA:29531]
synonym: "dolichylphosphomannose-dependent ALG9 mannosyltransferase activity" RELATED [EC:2.4.1.259]
xref: EC:2.4.1.259
xref: KEGG_REACTION:R06259
xref: MetaCyc:RXN-5467
xref: RHEA:29531
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity

[Term]
id: GO:0052927
name: CTP:tRNA cytidylyltransferase activity
namespace: molecular_function
alt_id: GO:0052928
def: "Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' CC end + 2 diphosphate." [PMID:31936900, PMID:33095240, RHEA:60008]
synonym: "CTP:3'-cytidine-tRNA cytidylyltransferase activity" RELATED []
xref: RHEA:60008
is_a: GO:0070567 ! cytidylyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0052929
name: ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate." [PMID:31936900, PMID:33095240, RHEA:60012]
synonym: "ATP:3'-CC-tRNA adenylyltransferase activity" EXACT []
synonym: "ATP:tRNA adenylyltransferase activity" BROAD []
xref: KEGG_REACTION:R09386
xref: RHEA:60012
is_a: GO:0070566 ! adenylyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0052933
name: alcohol dehydrogenase (cytochrome c(L)) activity
namespace: molecular_function
alt_id: GO:0052930
alt_id: GO:0052931
alt_id: GO:0052932
def: "Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+." [RHEA:51004]
synonym: "2-chloroethanol cytochrome-c oxidoreductase activity" NARROW []
synonym: "alcohol:cytochrome c(L) oxidoreductase activity" EXACT []
synonym: "ethanol cytochrome-c oxidoreductase activity" NARROW []
synonym: "methanol dehydrogenase activity" NARROW [EC:1.1.2.7]
synonym: "methanol ferricytochrome-c oxidoreductase activity" NARROW []
xref: EC:1.1.2.7
xref: KEGG_REACTION:R10713
xref: MetaCyc:RXN-11332
xref: RHEA:51004
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0052934
name: alcohol dehydrogenase (cytochrome c) activity
namespace: molecular_function
alt_id: GO:0018468
alt_id: GO:0052935
alt_id: GO:0052936
def: "Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+." [RHEA:51020]
synonym: "2-chloroethanol:cytochrome c oxidoreductase activity" NARROW []
synonym: "alcohol dehydrogenase (acceptor) activity" BROAD []
synonym: "alcohol:(acceptor) oxidoreductase activity" RELATED []
synonym: "alcohol:acceptor oxidoreductase activity" RELATED []
synonym: "alcohol:cytochrome c oxidoreductase activity" EXACT []
synonym: "ethanol:cytochrome c oxidoreductase activity" NARROW []
synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT []
synonym: "quinoprotein alcohol dehydrogenase activity" RELATED []
xref: EC:1.1.2.8
xref: KEGG_REACTION:R05198
xref: KEGG_REACTION:R05285
xref: MetaCyc:RXN-11333
xref: RHEA:51020
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0055001
name: muscle cell development
namespace: biological_process
alt_id: GO:0048747
def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]
synonym: "muscle fiber development" EXACT []
synonym: "muscle fibre development" EXACT []
synonym: "myofiber development" EXACT []
synonym: "myofibre development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0055002
name: striated muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol]
is_a: GO:0055001 ! muscle cell development
relationship: part_of GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0055003
name: cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "cardiac myofibril development" EXACT []
synonym: "cardiac myofibril morphogenesis" EXACT []
synonym: "heart myofibril assembly" RELATED []
is_a: GO:0030239 ! myofibril assembly
relationship: part_of GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055004
name: atrial cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "atrial cardiac myofibril development" EXACT [GOC:dph]
synonym: "atrial heart myofibril development" EXACT []
is_a: GO:0055003 ! cardiac myofibril assembly
relationship: part_of GO:0055014 ! atrial cardiac muscle cell development

[Term]
id: GO:0055005
name: ventricular cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "ventricular cardiac myofibril development" RELATED []
synonym: "ventricular heart myofibril development" EXACT []
is_a: GO:0055003 ! cardiac myofibril assembly
relationship: part_of GO:0055015 ! ventricular cardiac muscle cell development

[Term]
id: GO:0055006
name: cardiac cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol]
synonym: "cardiocyte development" EXACT [GOC:dph]
synonym: "heart cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:0055007
name: cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiomyocyte differentiation" EXACT []
synonym: "heart muscle cell differentiation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0051146 ! striated muscle cell differentiation
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055008
name: cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol]
synonym: "heart muscle morphogenesis" EXACT []
synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055009
name: atrial cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol]
synonym: "atrial heart muscle morphogenesis" EXACT []
synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac atrium muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development

[Term]
id: GO:0055010
name: ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol]
synonym: "cardiac ventricle muscle morphogenesis" EXACT []
synonym: "ventricular heart muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis
relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development

[Term]
id: GO:0055011
name: atrial cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol, GOC:mtg_heart]
synonym: "atrial cardiomyocyte differentiation" EXACT []
synonym: "atrial heart muscle cell differentiation" EXACT []
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055012
name: ventricular cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_heart]
synonym: "ventricular cardiomyocyte differentiation" EXACT []
synonym: "ventricular heart muscle cell differentiation" EXACT []
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055013
name: cardiac muscle cell development
namespace: biological_process
alt_id: GO:0048739
def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiac muscle fiber development" EXACT []
synonym: "cardiac muscle fibre development" EXACT []
synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle]
synonym: "heart muscle cell development" EXACT []
synonym: "heart muscle fiber development" RELATED []
is_a: GO:0055002 ! striated muscle cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055014
name: atrial cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol]
synonym: "atrial cardiomyocyte development" EXACT []
synonym: "atrial heart muscle development" EXACT []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation

[Term]
id: GO:0055015
name: ventricular cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_muscle]
synonym: "ventricular cardiomyocyte development" EXACT []
synonym: "ventricular heart muscle cell development" EXACT []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation

[Term]
id: GO:0055016
name: hypochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta." [GOC:devbiol, GOC:lb]
synonym: "subnotochordal rod development" EXACT []
is_a: GO:0009888 ! tissue development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0055017
name: cardiac muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol]
synonym: "heart muscle growth" EXACT []
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0060419 ! heart growth

[Term]
id: GO:0055018
name: regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "regulation of cardiac muscle fibre development" EXACT []
synonym: "regulation of heart muscle fiber development" EXACT []
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
relationship: regulates GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055019
name: negative regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "down regulation of cardiac muscle fiber development" EXACT []
synonym: "down-regulation of cardiac muscle fiber development" EXACT []
synonym: "downregulation of cardiac muscle fiber development" EXACT []
synonym: "inhibition of cardiac muscle fiber development" NARROW []
synonym: "negative regulation of cardiac muscle fibre development" EXACT []
synonym: "negative regulation of heart muscle fiber development" RELATED []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
relationship: negatively_regulates GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055020
name: positive regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "activation of cardiac muscle fiber development" NARROW []
synonym: "positive regulation of cardiac muscle fibre development" EXACT []
synonym: "positive regulation of heart muscle fiber development" EXACT []
synonym: "stimulation of cardiac muscle fiber development" NARROW []
synonym: "up regulation of cardiac muscle fiber development" EXACT []
synonym: "up-regulation of cardiac muscle fiber development" EXACT []
synonym: "upregulation of cardiac muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation
relationship: positively_regulates GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055021
name: regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
is_a: GO:0060420 ! regulation of heart growth
relationship: regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055022
name: negative regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "down regulation of cardiac muscle growth" EXACT []
synonym: "down-regulation of cardiac muscle growth" EXACT []
synonym: "downregulation of cardiac muscle growth" EXACT []
synonym: "inhibition of cardiac muscle growth" NARROW []
synonym: "negative regulation of heart muscle growth" RELATED []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0061117 ! negative regulation of heart growth
relationship: negatively_regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055023
name: positive regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "activation of cardiac muscle growth" NARROW []
synonym: "positive regulation of heart muscle growth" EXACT []
synonym: "stimulation of cardiac muscle growth" NARROW []
synonym: "up regulation of cardiac muscle growth" EXACT []
synonym: "up-regulation of cardiac muscle growth" EXACT []
synonym: "upregulation of cardiac muscle growth" EXACT []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0060421 ! positive regulation of heart growth
relationship: positively_regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055024
name: regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "regulation of heart muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
relationship: regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055025
name: positive regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "activation of cardiac muscle development" NARROW []
synonym: "positive regulation of heart muscle development" EXACT []
synonym: "stimulation of cardiac muscle development" NARROW []
synonym: "up regulation of cardiac muscle development" EXACT []
synonym: "up-regulation of cardiac muscle development" EXACT []
synonym: "upregulation of cardiac muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
relationship: positively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055026
name: negative regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "down regulation of cardiac muscle development" EXACT []
synonym: "down-regulation of cardiac muscle development" EXACT []
synonym: "downregulation of cardiac muscle development" EXACT []
synonym: "inhibition of cardiac muscle development" NARROW []
synonym: "negative regulation of heart muscle development" EXACT []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
relationship: negatively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055028
name: cortical microtubule
namespace: cellular_component
def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu]
is_a: GO:0005881 ! cytoplasmic microtubule
relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton

[Term]
id: GO:0055029
name: nuclear DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0055034
name: Bolwig's organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [GOC:mtg_sensu]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0055035
name: plastid thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jid, GOC:rph]
is_a: GO:0042170 ! plastid membrane
is_a: GO:0042651 ! thylakoid membrane
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0055036
name: virion membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a virion." [GOC:jid, GOC:rph, PMID:213106]
subset: goslim_chembl
is_a: GO:0044423 ! virion component

[Term]
id: GO:0055037
name: recycling endosome
namespace: cellular_component
def: "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
synonym: "endosomal recycling compartment" EXACT [PMID:20820847]
synonym: "endosome recycling compartment" RELATED [GOC:dph, PMID:12370264]
synonym: "ERC" RELATED [GOC:dph, PMID:1237064]
is_a: GO:0005768 ! endosome

[Term]
id: GO:0055038
name: recycling endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a recycling endosome." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0055037 ! recycling endosome

[Term]
id: GO:0055039
name: trichocyst
namespace: cellular_component
def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in net-like structures, to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jid, GOC:rph, PMID:3667715]
xref: Wikipedia:Trichocyst
is_a: GO:0043264 ! extracellular membraneless organelle

[Term]
id: GO:0055040
name: periplasmic flagellum
namespace: cellular_component
def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jid, GOC:rph, PMID:15175283, PMID:1624463]
is_a: GO:0009288 ! bacterial-type flagellum
relationship: part_of GO:0042597 ! periplasmic space

[Term]
id: GO:0055041
name: cyclopentanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + H+ + NADH." [EC:1.1.1.163, RHEA:11728]
synonym: "cyclopentanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.163]
synonym: "cyclopentanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.163]
xref: EC:1.1.1.163
xref: KEGG_REACTION:R02553
xref: MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN
xref: RHEA:11728
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0055042
name: 5-valerolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jid, GOC:mlg]
is_a: GO:0046573 ! lactonohydrolase activity

[Term]
id: GO:0055043
name: 5-oxovalerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jid, GOC:mlg]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0055044
name: symplast
namespace: cellular_component
def: "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu]
subset: goslim_pir
xref: Wikipedia:Symplast
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0055045
name: antipodal cell degeneration
namespace: biological_process
def: "The process in which the antipodal cells undergo programmed cell death." [GOC:mtg_plant]
is_a: GO:0010623 ! programmed cell death involved in cell development
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0055046
name: microgametogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure." [GOC:mtg_plant]
synonym: "pollen development from the microspore" EXACT systematic_synonym []
xref: Wikipedia:Microgametogenesis
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0055047
name: generative cell mitosis
namespace: biological_process
def: "The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant]
is_a: GO:0140014 ! mitotic nuclear division
relationship: part_of GO:0048232 ! male gamete generation

[Term]
id: GO:0055048
name: anastral spindle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins." [GOC:expert_rg, GOC:mtg_sensu, GOC:tb, PMID:15034926]
is_a: GO:0051225 ! spindle assembly

[Term]
id: GO:0055049
name: obsolete astral spindle assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes." [GOC:tb]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true
consider: GO:0051225

[Term]
id: GO:0055050
name: obsolete astral spindle assembly involved in male meiosis
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells." [GOC:tb]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true
consider: GO:0090306

[Term]
id: GO:0055051
name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding
namespace: cellular_component
def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a half transporter. Two half-transporters come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0055052
name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
namespace: cellular_component
def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0055053
name: mannose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct]
synonym: "mannose:hydrogen symporter activity" EXACT []
is_a: GO:0009679 ! hexose:proton symporter activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0055054
name: fructose:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct]
synonym: "fructose:hydrogen symporter activity" EXACT []
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0009679 ! hexose:proton symporter activity

[Term]
id: GO:0055055
name: obsolete glucose:proton symporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose." [GOC:ct]
comment: This term was obsoleted because it represents the same reaction as D-glucose:proton symporter activity ; GO_0005356.
synonym: "D-glucose:hydrogen symporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0005356

[Term]
id: GO:0055056
name: D-glucose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015579
def: "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:jid, GOC:jsg, GOC:mah]
xref: Reactome:R-HSA-429094 "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-450095 "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region"
xref: Reactome:R-HSA-5339524 "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-5632804 "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-5632871 "Defective SLC2A10 does not transport Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-8981553 "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-8981564 "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-8981570 "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-8981574 "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol"
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0055057
name: neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167]
synonym: "neuroblast cell division" EXACT []
is_a: GO:0051301 ! cell division
relationship: part_of GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0055058
name: symmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells." [GOC:dph]
is_a: GO:0055057 ! neuroblast division

[Term]
id: GO:0055059
name: asymmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0045165 ! cell fate commitment
is_a: GO:0055057 ! neuroblast division

[Term]
id: GO:0055060
name: asymmetric neuroblast division resulting in ganglion mother cell formation
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph]
is_a: GO:0014017 ! neuroblast fate commitment
is_a: GO:0055059 ! asymmetric neuroblast division

[Term]
id: GO:0055061
name: obsolete di-, tri-valent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was made obsolete because it has been split.
synonym: "di-, tri-valent inorganic anion homeostasis" EXACT []
is_obsolete: true
consider: GO:0055081

[Term]
id: GO:0055062
name: phosphate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." [GOC:jid, GOC:mah]
synonym: "phosphate homeostasis" BROAD []
synonym: "Pi homeostasis" EXACT []
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055063
name: sulfate ion homeostasis
namespace: biological_process
alt_id: GO:0080174
def: "Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell." [GOC:jid, GOC:mah]
synonym: "sulfate homeostasis" EXACT []
synonym: "sulphate ion homeostasis" EXACT []
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055064
name: chloride ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055081 ! monoatomic anion homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055065
name: obsolete metal ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
consider: GO:0030003

[Term]
id: GO:0055066
name: obsolete di-, tri-valent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
comment: This term was made obsolete because it has been split.
synonym: "di-, tri-valent inorganic cation homeostasis" EXACT []
is_obsolete: true
consider: GO:0055080

[Term]
id: GO:0055067
name: obsolete monovalent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0055080

[Term]
id: GO:0055068
name: obsolete cobalt ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "cobalt homeostasis" BROAD []
is_obsolete: true
consider: GO:0006877

[Term]
id: GO:0055069
name: obsolete zinc ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent. For homeostasis terms, we would like to specify whether the homeostasis takes place intracellularly or at the level of the organism.
synonym: "zinc homeostasis" BROAD []
is_obsolete: true
consider: GO:0006882
consider: GO:0180002

[Term]
id: GO:0055070
name: copper ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
synonym: "copper homeostasis" BROAD []
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055071
name: manganese ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell." [GOC:jid, GOC:mah]
synonym: "manganese homeostasis" BROAD []
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055072
name: obsolete iron ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "iron homeostasis" BROAD []
is_obsolete: true
consider: GO:0006879
consider: GO:0060586

[Term]
id: GO:0055073
name: obsolete cadmium ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was obsoleted because it is not a normal process.
synonym: "cadmium homeostasis" EXACT []
is_obsolete: true
consider: GO:0071585

[Term]
id: GO:0055074
name: calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
synonym: "regulation of calcium ion concentration" EXACT []
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055075
name: potassium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055076
name: obsolete transition metal ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
consider: GO:0030003

[Term]
id: GO:0055077
name: gap junction hemi-channel activity
namespace: molecular_function
def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh]
synonym: "connexon channel activity" EXACT []
is_a: GO:0022829 ! wide pore channel activity
relationship: part_of GO:0005243 ! gap junction channel activity

[Term]
id: GO:0055078
name: sodium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055079
name: obsolete aluminum ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell." [GOC:jid, GOC:lr, GOC:mah]
comment: This term was obsoleted because this process is not believed to exist.
synonym: "aluminium ion homeostasis" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0140982

[Term]
id: GO:0055080
name: monoatomic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]
synonym: "cation homeostasis" BROAD []
is_a: GO:0050801 ! monoatomic ion homeostasis

[Term]
id: GO:0055081
name: monoatomic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of monoatomic anions within an organism or cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]
synonym: "anion homeostasis" BROAD []
is_a: GO:0050801 ! monoatomic ion homeostasis

[Term]
id: GO:0055082
name: intracellular chemical homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." [GOC:isa_complete, GOC:jid]
synonym: "cellular chemical homeostasis" EXACT []
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0055083
name: obsolete monovalent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0055081

[Term]
id: GO:0055085
name: transmembrane transport
namespace: biological_process
alt_id: GO:0090662
def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "ATP hydrolysis coupled transmembrane transport" NARROW []
synonym: "membrane transport" EXACT []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0055086
name: nucleobase-containing small molecule metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0055087
name: Ski complex
namespace: cellular_component
def: "A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677]
xref: Wikipedia:Ski_complex
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0055088
name: lipid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0055089
name: fatty acid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055090
name: acylglycerol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell." [GOC:BHF, GOC:rl]
synonym: "glyceride homeostasis" EXACT []
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055091
name: phospholipid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055092
name: sterol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055093
name: response to hyperoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv]
synonym: "response to hyperoxic stress" EXACT []
synonym: "response to increased oxygen tension" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0036296 ! response to increased oxygen levels

[Term]
id: GO:0055094
name: response to lipoprotein particle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:BHF, GOC:rl]
synonym: "response to lipoprotein particle stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0055095
name: lipoprotein particle mediated signaling
namespace: biological_process
def: "The series of molecular signals mediated by the detection of a lipoprotein particle." [GOC:BHF, GOC:rl]
synonym: "lipoprotein mediated signalling" EXACT []
synonym: "lipoprotein particle mediated signal transduction" EXACT [GOC:signaling]
synonym: "lipoprotein particle-mediated signaling" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071402 ! cellular response to lipoprotein particle stimulus

[Term]
id: GO:0055096
name: low-density lipoprotein particle mediated signaling
namespace: biological_process
def: "The series of molecular signals mediated by the detection of low-density lipoprotein particle." [GOC:BHF, GOC:rl, PMID:16013438]
synonym: "low-density lipoprotein mediated signalling" EXACT []
synonym: "low-density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling]
synonym: "low-density lipoprotein particle-mediated signaling" EXACT []
is_a: GO:0055095 ! lipoprotein particle mediated signaling
relationship: part_of GO:0071404 ! cellular response to low-density lipoprotein particle stimulus

[Term]
id: GO:0055097
name: high density lipoprotein particle mediated signaling
namespace: biological_process
def: "The series of molecular signals mediated by the detection of high density lipoprotein particle." [GOC:BHF, GOC:rl]
synonym: "high density lipoprotein mediated signalling" EXACT []
synonym: "high density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling]
synonym: "high density lipoprotein particle-mediated signaling" EXACT []
is_a: GO:0055095 ! lipoprotein particle mediated signaling
relationship: part_of GO:0071403 ! cellular response to high density lipoprotein particle stimulus

[Term]
id: GO:0055100
name: adiponectin binding
namespace: molecular_function
def: "Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:BHF, GOC:rl, PMID:15210937]
is_a: GO:0005515 ! protein binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0055101
name: obsolete glycerophospholipase inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:BHF, GOC:rl]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'glycerophosphate activity', which also cannot be found in the literature.
synonym: "glycerophospholipase inhibitor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0055102
name: lipase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0055103
name: ligase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a ligase." [GOC:BHF, GOC:rl]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0055104
name: ligase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a ligase." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0055103 ! ligase regulator activity

[Term]
id: GO:0055105
name: ubiquitin-protein transferase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity

[Term]
id: GO:0055106
name: ubiquitin-protein transferase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0055107
name: Golgi to secretory granule transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0055108
name: Golgi to transport vesicle transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid]
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0055109
name: invagination involved in gastrulation with mouth forming second
namespace: biological_process
def: "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055110
name: involution involved in gastrulation with mouth forming second
namespace: biological_process
def: "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055111
name: ingression involved in gastrulation with mouth forming second
namespace: biological_process
def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055112
name: delamination involved in gastrulation with mouth forming second
namespace: biological_process
def: "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0060232 ! delamination
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055113
name: epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0090504 ! epiboly
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055114
name: obsolete oxidation-reduction process
namespace: biological_process
def: "OBSOLETE. A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
comment: This term was obsoleted because it represents a molecular function.
synonym: "oxidation reduction" EXACT []
synonym: "oxidoreductase process" EXACT systematic_synonym []
is_obsolete: true

[Term]
id: GO:0055115
name: entry into diapause
namespace: biological_process
def: "The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:ds, GOC:jid, GOC:mah]
xref: Wikipedia:Diapause
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0055116
name: entry into reproductive diapause
namespace: biological_process
def: "The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ds, GOC:jid, GOC:mah]
is_a: GO:0055115 ! entry into diapause

[Term]
id: GO:0055117
name: regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0008016 ! regulation of heart contraction
relationship: regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055118
name: negative regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0045822 ! negative regulation of heart contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055119
name: relaxation of cardiac muscle
namespace: biological_process
def: "The process in which the extent of cardiac muscle contraction is reduced." [GOC:ecd]
is_a: GO:0090075 ! relaxation of muscle

[Term]
id: GO:0055120
name: striated muscle dense body
namespace: cellular_component
def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmv, PMID:17492481]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043292 ! contractile muscle fiber

[Term]
id: GO:0055121
name: response to high fluence blue light stimulus by blue high-fluence system
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2." [GOC:mtg_far_red]
synonym: "response to high fluence blue light" BROAD []
synonym: "response to high fluence blue light by bhf system" RELATED []
is_a: GO:0009637 ! response to blue light
is_a: GO:0009644 ! response to high light intensity

[Term]
id: GO:0055122
name: response to very low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0055123
name: digestive system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid]
is_a: GO:0048731 ! system development

[Term]
id: GO:0055124
name: obsolete premature neural plate formation
namespace: biological_process
def: "OBSOLETE. The formation of the neural plate before the appropriate time." [GOC:jid]
synonym: "premature neural plate formation" EXACT []
is_obsolete: true

[Term]
id: GO:0055125
name: obsolete Nic96 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p." [GOC:jh, PMID:12791264, PMID:15741174]
synonym: "Nic96 complex" EXACT []
is_obsolete: true
consider: GO:0044612

[Term]
id: GO:0055126
name: obsolete Nup82 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p." [GOC:jh, PMID:12791264, PMID:15741174]
synonym: "Nup82 complex" EXACT []
is_obsolete: true
consider: GO:0044612

[Term]
id: GO:0055127
name: vibrational conductance of sound to the inner ear
namespace: biological_process
def: "The transmission of vibrations via ossicles to the inner ear." [GOC:mh]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0007605 ! sensory perception of sound

[Term]
id: GO:0055129
name: L-proline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]
synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" BROAD []
is_a: GO:0006561 ! proline biosynthetic process

[Term]
id: GO:0055130
name: D-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine." [GOC:ecd]
synonym: "(2R)-2-aminopropanoic acid catabolic process" EXACT []
is_a: GO:0006524 ! alanine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046436 ! D-alanine metabolic process

[Term]
id: GO:0055131
name: C3HC4-type RING finger domain binding
namespace: molecular_function
def: "Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway." [GOC:amm, InterPro:IPR001841, InterPro:IPR018957]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0060001
name: minus-end directed microfilament motor activity
namespace: molecular_function
def: "A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557]
synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph]
synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph]
synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph]
is_a: GO:0000146 ! microfilament motor activity

[Term]
id: GO:0060002
name: plus-end directed microfilament motor activity
namespace: molecular_function
def: "A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557]
synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph]
synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph]
synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph]
is_a: GO:0000146 ! microfilament motor activity

[Term]
id: GO:0060003
name: copper ion export
namespace: biological_process
def: "The directed movement of copper ions out of a cell or organelle." [GOC:dph]
synonym: "copper export" EXACT [GOC:dph]
is_a: GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0060004
name: reflex
namespace: biological_process
def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:0877797099]
xref: Wikipedia:Reflex
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0060005
name: vestibular reflex
namespace: biological_process
def: "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060006
name: angular vestibuloocular reflex
namespace: biological_process
def: "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757]
is_a: GO:0060005 ! vestibular reflex

[Term]
id: GO:0060007
name: linear vestibuloocular reflex
namespace: biological_process
def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757]
is_a: GO:0060005 ! vestibular reflex

[Term]
id: GO:0060008
name: Sertoli cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0060009
name: Sertoli cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0060008 ! Sertoli cell differentiation

[Term]
id: GO:0060010
name: Sertoli cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of Sertoli cells is acquired and determined." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0060008 ! Sertoli cell differentiation

[Term]
id: GO:0060011
name: Sertoli cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0060012
name: synaptic transmission, glycinergic
namespace: biological_process
def: "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]
synonym: "glycinergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0060013
name: righting reflex
namespace: biological_process
def: "A reflex process in which an animal immediately tries to turn over after being placed in a supine position." [GOC:dph, PMID:8635460]
synonym: "righting response" EXACT [GOC:dph]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060014
name: granulosa cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0060015
name: granulosa cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become granulosa cells." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0060014 ! granulosa cell differentiation

[Term]
id: GO:0060016
name: granulosa cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0060014 ! granulosa cell differentiation

[Term]
id: GO:0060017
name: parathyroid gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0060018
name: astrocyte fate commitment
namespace: biological_process
def: "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte." [GOC:dph]
is_a: GO:0021781 ! glial cell fate commitment
relationship: part_of GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0060019
name: radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph]
is_a: GO:0010001 ! glial cell differentiation

[Term]
id: GO:0060020
name: Bergmann glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501]
is_a: GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0060021
name: roof of mouth development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544]
synonym: "palatum development" EXACT [ISBN:0721662544]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0060022
name: hard palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes." [GOC:dph, ISBN:0721662544]
synonym: "palatum durum development" EXACT [ISBN:0721662544]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0062009 ! secondary palate development

[Term]
id: GO:0060023
name: soft palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate." [GOC:dph, ISBN:0721662544]
synonym: "palatum molle development" EXACT [ISBN:0721662544]
synonym: "velum palatum development" EXACT [ISBN:0721662544]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0062009 ! secondary palate development

[Term]
id: GO:0060024
name: rhythmic synaptic transmission
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph]
is_a: GO:0050804 ! modulation of chemical synaptic transmission

[Term]
id: GO:0060025
name: regulation of synaptic activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: part_of GO:0050803 ! regulation of synapse structure or activity

[Term]
id: GO:0060026
name: convergent extension
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:dgf, GOC:dph, PMID:12062082]
xref: Wikipedia:Convergent_extension
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0060027
name: convergent extension involved in gastrulation
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0060028
name: convergent extension involved in axis elongation
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082]
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0003401 ! axis elongation

[Term]
id: GO:0060029
name: convergent extension involved in organogenesis
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082]
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0060030
name: dorsal convergence
namespace: biological_process
def: "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement." [GOC:dgf, GOC:dph, PMID:12062082]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:0060031
name: mediolateral intercalation
namespace: biological_process
def: "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dgf, GOC:dph, PMID:12062082]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:0060032
name: notochord regression
namespace: biological_process
def: "The developmental process in which the structure of the notochord is destroyed in an embryo." [GOC:dph]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0048570 ! notochord morphogenesis

[Term]
id: GO:0060033
name: anatomical structure regression
namespace: biological_process
def: "The developmental process in which an anatomical structure is destroyed as a part of its normal progression." [GOC:dph]
synonym: "histolysis" RELATED [GOC:mtg_apoptosis]
synonym: "tissue death" RELATED [GOC:mtg_apoptosis]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0060034
name: notochord cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030903 ! notochord development

[Term]
id: GO:0060035
name: notochord cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060034 ! notochord cell differentiation

[Term]
id: GO:0060036
name: notochord cell vacuolation
namespace: biological_process
def: "The assembly and arrangement of a vacuole within a cell of the notochord." [GOC:cb, GOC:dph, PMID:10964477]
is_a: GO:0007033 ! vacuole organization
relationship: part_of GO:0060035 ! notochord cell development

[Term]
id: GO:0060037
name: pharyngeal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph]
is_a: GO:0048731 ! system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0060038
name: cardiac muscle cell proliferation
namespace: biological_process
def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571]
synonym: "cardiac myocyte proliferation" EXACT []
synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473]
synonym: "heart muscle cell proliferation" EXACT []
is_a: GO:0014855 ! striated muscle cell proliferation
relationship: part_of GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0060039
name: pericardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060040
name: retinal bipolar neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:1905962 ! glutamatergic neuron differentiation
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060041
name: retina development in camera-type eye
namespace: biological_process
alt_id: GO:0002073
def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729]
synonym: "retina development in camera-style eye" EXACT []
synonym: "retinal development" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0060042
name: retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu]
synonym: "retina morphogenesis in camera-style eye" EXACT []
synonym: "retinogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0060043
name: regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph]
synonym: "regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
relationship: regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060044
name: negative regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "negative regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060045
name: positive regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "positive regulation of heart muscle cell proliferation" RELATED []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060046
name: regulation of acrosome reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the acrosome reaction." [GOC:dph]
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0007340 ! acrosome reaction

[Term]
id: GO:0060047
name: heart contraction
namespace: biological_process
def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
synonym: "cardiac contraction" RELATED []
synonym: "heart beating" EXACT []
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003015 ! heart process
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0060048
name: cardiac muscle contraction
namespace: biological_process
def: "Muscle contraction of cardiac muscle tissue." [GOC:dph]
synonym: "heart muscle contraction" EXACT []
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0060047 ! heart contraction

[Term]
id: GO:0060049
name: regulation of protein glycosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
synonym: "regulation of protein amino acid glycosylation" EXACT [GOC:bf]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0006486 ! protein glycosylation

[Term]
id: GO:0060050
name: positive regulation of protein glycosylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
synonym: "positive regulation of protein amino acid glycosylation" EXACT [GOC:bf]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0060049 ! regulation of protein glycosylation
relationship: positively_regulates GO:0006486 ! protein glycosylation

[Term]
id: GO:0060051
name: negative regulation of protein glycosylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
synonym: "negative regulation of protein amino acid glycosylation" EXACT [GOC:bf]
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0060049 ! regulation of protein glycosylation
relationship: negatively_regulates GO:0006486 ! protein glycosylation

[Term]
id: GO:0060052
name: neurofilament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph]
synonym: "neurofilament cytoskeleton organisation" EXACT [GOC:mah]
synonym: "neurofilament cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045104 ! intermediate filament cytoskeleton organization

[Term]
id: GO:0060053
name: neurofilament cytoskeleton
namespace: cellular_component
def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph]
is_a: GO:0045111 ! intermediate filament cytoskeleton

[Term]
id: GO:0060054
name: positive regulation of epithelial cell proliferation involved in wound healing
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0060055
name: angiogenesis involved in wound healing
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218]
is_a: GO:0001525 ! angiogenesis
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0060056
name: mammary gland involution
namespace: biological_process
def: "The tissue remodeling that removes differentiated mammary epithelia during weaning." [GOC:dph, PMID:15282149]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0060443 ! mammary gland morphogenesis

[Term]
id: GO:0060057
name: apoptotic process involved in mammary gland involution
namespace: biological_process
def: "Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in mammary gland involution" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
relationship: part_of GO:0060056 ! mammary gland involution

[Term]
id: GO:0060058
name: positive regulation of apoptotic process involved in mammary gland involution
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution." [GOC:dph, GOC:mtg_apoptosis, PMID:15282149]
synonym: "positive regulation of apoptosis involved in mammary gland involution" NARROW []
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
relationship: positively_regulates GO:0060057 ! apoptotic process involved in mammary gland involution

[Term]
id: GO:0060059
name: embryonic retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage." [GOC:dgh, GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060060
name: post-embryonic retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage." [GOC:dgh, GOC:dph]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060061
name: Spemann organizer formation
namespace: biological_process
def: "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph]
synonym: "Spemann's organizer formation" EXACT []
synonym: "Spemann-Mangold organizer formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0031128 ! developmental induction

[Term]
id: GO:0060062
name: Spemann organizer formation at the dorsal lip of the blastopore
namespace: biological_process
def: "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, PMID:9442883]
comment: Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish.
synonym: "Spemann's organizer formation at the dorsal lip of the blastopore" EXACT []
synonym: "Spemann-Mangold organizer formation at the dorsal lip of the blastopore" EXACT []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060063
name: Spemann organizer formation at the embryonic shield
namespace: biological_process
def: "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan." [GOC:dph, PMID:9442883]
comment: Occurs in Teleost fish.
synonym: "Spemann's organizer formation at the embryonic shield" EXACT []
synonym: "Spemann-Mangold organizer formation at the embryonic shield" EXACT []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060064
name: Spemann organizer formation at the anterior end of the primitive streak
namespace: biological_process
def: "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan." [GOC:dph, PMID:9442883]
comment: Occurs in reptiles, birds and mammals.
synonym: "Spemann organizer formation in amniotes" RELATED []
synonym: "Spemann's organizer formation at the anterior end of the primitive streak" EXACT []
synonym: "Spemann-Mangold organizer formation at the anterior end of the primitive streak" RELATED []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060065
name: uterus development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ebc]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060066
name: oviduct development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, PMID:22918811, PMID:27875265]
synonym: "fallopian tube development" NARROW [GOC:bf]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0035295 ! tube development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060067
name: cervix development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ebc]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060068
name: vagina development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ebc]
is_a: GO:0030540 ! female genitalia development

[Term]
id: GO:0060069
name: Wnt signaling pathway, regulating spindle positioning
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle." [GOC:bf, GOC:dph, PMID:11532397]
synonym: "non-canonical Wnt signaling pathway" BROAD []
synonym: "Wnt receptor signaling pathway, regulating spindle positioning" EXACT []
synonym: "Wnt receptor signalling pathway, regulating spindle positioning" EXACT []
synonym: "Wnt-activated signaling pathway, regulating spindle positioning" EXACT [GOC:signaling]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032879 ! regulation of localization
is_a: GO:0035567 ! non-canonical Wnt signaling pathway
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0040001 ! establishment of mitotic spindle localization

[Term]
id: GO:0060070
name: canonical Wnt signaling pathway
namespace: biological_process
def: "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]
synonym: "canonical Wnt receptor signaling pathway" EXACT [GOC:signaling]
synonym: "canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "frizzled-1 receptor signaling pathway" NARROW []
synonym: "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
synonym: "Wnt receptor signaling pathway via beta-catenin" EXACT []
synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT []
is_a: GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0060071
name: Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton." [PMID:11532397, PMID:25349257, PMID:28293032, PMID:37804416]
synonym: "non-canonical Wnt signaling pathway" RELATED [GOC:bf]
synonym: "PCP pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "planar cell polarity pathway" EXACT [GOC:cjm]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway" EXACT []
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT []
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling]
synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf]
synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rph]
is_a: GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:0060072
name: large conductance calcium-activated potassium channel activity
namespace: molecular_function
alt_id: GO:0022895
def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074]
synonym: "BK calcium-activated potassium channel activity" EXACT []
synonym: "BK channel activity" RELATED []
synonym: "BK KCa channel activity" EXACT []
synonym: "large conductance KCa channel activity" EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0060073
name: micturition
namespace: biological_process
def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph]
synonym: "urination" EXACT []
synonym: "urine voiding" EXACT []
xref: Wikipedia:Urination
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion

[Term]
id: GO:0060074
name: synapse maturation
namespace: biological_process
def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "synaptic maturation" EXACT []
is_a: GO:0021700 ! developmental maturation
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0060075
name: regulation of resting membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized." [GOC:dph, GOC:ef, ISBN:0195088433]
synonym: "regulation of resting potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060076
name: excitatory synapse
namespace: cellular_component
def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef]
xref: Wikipedia:Excitatory_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0060077
name: inhibitory synapse
namespace: cellular_component
def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef]
xref: Wikipedia:Inhibitory_postsynaptic_potential
is_a: GO:0045202 ! synapse

[Term]
id: GO:0060078
name: regulation of postsynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "regulation of post-synaptic membrane potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060079
name: excitatory postsynaptic potential
namespace: biological_process
def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef]
synonym: "regulation of EPSP" RELATED []
synonym: "regulation of excitatory post-synaptic membrane potential" EXACT []
is_a: GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0060080
name: inhibitory postsynaptic potential
namespace: biological_process
def: "A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dph, GOC:ef]
synonym: "IPSP" RELATED []
synonym: "regulation of inhibitory post-synaptic membrane potential" EXACT []
is_a: GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0060081
name: membrane hyperpolarization
namespace: biological_process
def: "The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential." [GOC:dph]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060082
name: eye blink reflex
namespace: biological_process
def: "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208]
synonym: "nictitating membrane reflex" EXACT []
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060083
name: smooth muscle contraction involved in micturition
namespace: biological_process
def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347]
synonym: "smooth muscle contraction involved in urination" RELATED []
synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph]
is_a: GO:0014832 ! urinary bladder smooth muscle contraction
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060084
name: synaptic transmission involved in micturition
namespace: biological_process
def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347]
synonym: "synaptic transmission involved in urination" RELATED []
is_a: GO:0007274 ! neuromuscular synaptic transmission
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060085
name: smooth muscle relaxation of the bladder outlet
namespace: biological_process
def: "A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347]
synonym: "synaptic transmission involved in urination" EXACT []
is_a: GO:0044557 ! relaxation of smooth muscle
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060086
name: circadian temperature homeostasis
namespace: biological_process
def: "Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb]
synonym: "circadian regulation of body temperature" RELATED []
synonym: "circadian thermoregulation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001659 ! temperature homeostasis
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0060087
name: relaxation of vascular associated smooth muscle
namespace: biological_process
alt_id: GO:1905657
alt_id: GO:1905658
alt_id: GO:1905659
def: "A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:dph, GOC:rph, GOC:TermGenie, PMID:15867178, PMID:19996365, PMID:27389411]
synonym: "negative regulation of relaxation of vascular smooth muscle" RELATED []
synonym: "positive regulation of relaxation of vascular smooth muscle" RELATED []
synonym: "regulation of relaxation of vascular smooth muscle" RELATED []
synonym: "relaxation of vascular smooth muscle" EXACT []
synonym: "vascular smooth muscle relaxation" EXACT []
is_a: GO:0044557 ! relaxation of smooth muscle
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
relationship: part_of GO:0042311 ! vasodilation

[Term]
id: GO:0060088
name: auditory receptor cell stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells." [GOC:dph, PMID:10978835]
synonym: "auditory receptor cell stereocilium organisation" EXACT []
synonym: "auditory receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0060122 ! inner ear receptor cell stereocilium organization
relationship: part_of GO:0002093 ! auditory receptor cell morphogenesis

[Term]
id: GO:0060089
name: molecular transducer activity
namespace: molecular_function
def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt]
subset: gocheck_do_not_annotate
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0060090
name: molecular adaptor activity
namespace: molecular_function
alt_id: GO:0032947
def: "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "binding, bridging" EXACT []
synonym: "protein complex scaffold activity" BROAD []
synonym: "protein-containing complex scaffold activity" BROAD []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0060091
name: kinocilium
namespace: cellular_component
def: "A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:cilia, GOC:dph, PMID:15882574]
xref: Wikipedia:Kinocilium
is_a: GO:0043005 ! neuron projection
is_a: GO:0097732 ! 9+2 non-motile cilium
relationship: part_of GO:0032421 ! stereocilium bundle
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0060092
name: regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060093
name: negative regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "negative regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
relationship: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060094
name: positive regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "positive regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
relationship: positively_regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060095
name: zinc potentiation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "zinc potentiation of glycinergic synaptic transmission" EXACT []
is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic

[Term]
id: GO:0060096
name: serotonin secretion, neurotransmission
namespace: biological_process
def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph]
synonym: "serotonin release, neurotransmission" RELATED [GOC:tb]
is_a: GO:0001820 ! serotonin secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0060097
name: cytoskeletal rearrangement involved in phagocytosis, engulfment
namespace: biological_process
def: "The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0007010 ! cytoskeleton organization
relationship: part_of GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060098
name: membrane reorganization involved in phagocytosis, engulfment
namespace: biological_process
def: "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
synonym: "membrane reorganisation involved in phagocytosis, engulfment" EXACT [GOC:mah]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060099
name: regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050764 ! regulation of phagocytosis
is_a: GO:1905153 ! regulation of membrane invagination
relationship: regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060100
name: positive regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
is_a: GO:1905155 ! positive regulation of membrane invagination
relationship: positively_regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060101
name: negative regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050765 ! negative regulation of phagocytosis
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
is_a: GO:1905154 ! negative regulation of membrane invagination
relationship: negatively_regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060102
name: collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0060103
name: obsolete collagen and cuticulin-based cuticle extracellular matrix part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true
consider: GO:0060102

[Term]
id: GO:0060104
name: surface coat of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060105
name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060106
name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060107
name: annuli extracellular matrix
namespace: cellular_component
def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "annulae" RELATED []
synonym: "annular rings" RELATED []
synonym: "annule(s)" RELATED []
synonym: "annulus" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060108
name: annular furrow extracellular matrix
namespace: cellular_component
def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kmv, ISSN:15518507]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060109
name: medial layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "medial layer struts" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060110
name: basal layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060111
name: alae of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060112
name: generation of ovulation cycle rhythm
namespace: biological_process
def: "The process which controls the timing of the type of sexual cycle seen in female mammals." [GOC:dph]
synonym: "generation of estrus cycle rhythm" EXACT []
synonym: "generation of menstrual cycle rhythm" RELATED []
synonym: "generation of oestrus cycle rhythm" EXACT []
is_a: GO:0022602 ! ovulation cycle process

[Term]
id: GO:0060113
name: inner ear receptor cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph]
synonym: "inner ear hair cell differentiation" EXACT []
is_a: GO:0042490 ! mechanoreceptor differentiation
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0060114
name: vestibular receptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph]
synonym: "vestibular hair cell differentiation" EXACT []
is_a: GO:0035315 ! hair cell differentiation
is_a: GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060115
name: vestibular receptor cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a vestibular receptor cell." [GOC:dph]
synonym: "vestibular hair cell fate commitment" EXACT []
is_a: GO:0060120 ! inner ear receptor cell fate commitment
relationship: part_of GO:0060114 ! vestibular receptor cell differentiation

[Term]
id: GO:0060116
name: vestibular receptor cell morphogenesis
namespace: biological_process
def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb]
synonym: "vestibular hair cell morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060118 ! vestibular receptor cell development

[Term]
id: GO:0060117
name: auditory receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "auditory hair cell development" EXACT []
is_a: GO:0060119 ! inner ear receptor cell development
relationship: part_of GO:0042491 ! inner ear auditory receptor cell differentiation

[Term]
id: GO:0060118
name: vestibular receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "vestibular hair cell development" EXACT []
is_a: GO:0060119 ! inner ear receptor cell development
relationship: part_of GO:0060114 ! vestibular receptor cell differentiation

[Term]
id: GO:0060119
name: inner ear receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "inner ear hair cell development" EXACT []
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060120
name: inner ear receptor cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become an inner ear receptor cell." [GOC:dph]
synonym: "inner ear hair cell fate commitment" EXACT []
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060121
name: vestibular receptor cell stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells." [GOC:dph]
synonym: "vestibular hair cell stereocilium organization" EXACT []
synonym: "vestibular receptor cell stereocilium organisation" EXACT [GOC:mah]
synonym: "vestibular receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0060122 ! inner ear receptor cell stereocilium organization
is_a: GO:0106027 ! neuron projection organization
relationship: part_of GO:0060116 ! vestibular receptor cell morphogenesis

[Term]
id: GO:0060122
name: inner ear receptor cell stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." [GOC:dph]
synonym: "inner ear hair cell receptor stereocilium organization" EXACT []
synonym: "inner ear receptor stereocilium organisation" EXACT [GOC:mah]
synonym: "inner ear receptor stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031175 ! neuron projection development
relationship: part_of GO:0060119 ! inner ear receptor cell development

[Term]
id: GO:0060123
name: regulation of growth hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060124
name: positive regulation of growth hormone secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060125
name: negative regulation of growth hormone secretion
namespace: biological_process
def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060126
name: somatotropin secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell differentiation" EXACT []
synonym: "somatotrope differentiation" RELATED []
synonym: "somatotroph differentiation" RELATED []
synonym: "somatotrophin secreting cell differentiation" EXACT []
synonym: "somatotropic cell differentiation" RELATED []
synonym: "somatrophic cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060127
name: prolactin secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil differentiation" EXACT []
synonym: "lactotrope differentiation" EXACT []
synonym: "lactotroph differentiation" EXACT []
synonym: "lactotropic cell differentiation" EXACT []
synonym: "mammotrope differentiation" EXACT []
synonym: "mammotroph differentiation" EXACT []
synonym: "mammotrophic cell differentiation" EXACT []
synonym: "mammotropic cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060128
name: corticotropin hormone secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT []
synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph]
synonym: "corticotrope differentiation" EXACT []
synonym: "corticotroph differentiation" EXACT []
synonym: "corticotrophin hormone secreting cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060129
name: thyroid-stimulating hormone-secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin." [GOC:dph]
synonym: "beta-basophil differentiation" EXACT []
synonym: "thyroid stimulating hormone secreting cell differentiation" EXACT []
synonym: "thyrotrope differentiation" EXACT []
synonym: "thyrotroph differentiation" EXACT []
synonym: "TSH-secreting cell differentiation" EXACT []
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060130
name: thyroid-stimulating hormone-secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph]
synonym: "beta-basophil development" EXACT []
synonym: "thyroid stimulating hormone secreting cell development" EXACT []
synonym: "thyrotrope development" EXACT []
synonym: "thyrotroph development" EXACT []
synonym: "TSH-secreting cell development" EXACT []
is_a: GO:0002068 ! glandular epithelial cell development
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0060129 ! thyroid-stimulating hormone-secreting cell differentiation

[Term]
id: GO:0060131
name: corticotropin hormone secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell development" EXACT []
synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph]
synonym: "corticotrope development" EXACT []
synonym: "corticotroph development" RELATED []
synonym: "corticotrophin hormone secreting cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060128 ! corticotropin hormone secreting cell differentiation

[Term]
id: GO:0060132
name: prolactin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil development" EXACT []
synonym: "lactotrope development" EXACT []
synonym: "lactotroph development" EXACT []
synonym: "lactotropic cell development" EXACT []
synonym: "mammotrope development" EXACT []
synonym: "mammotroph development" EXACT []
synonym: "mammotrophic cell development" EXACT []
synonym: "mammotropic cell development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060127 ! prolactin secreting cell differentiation

[Term]
id: GO:0060133
name: somatotropin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell development" EXACT []
synonym: "somatotrope development" RELATED []
synonym: "somatotroph development" RELATED []
synonym: "somatotrophin secreting cell development" EXACT []
synonym: "somatotropic cell development" EXACT []
synonym: "somatrophic cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060126 ! somatotropin secreting cell differentiation

[Term]
id: GO:0060134
name: prepulse inhibition
namespace: biological_process
def: "The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse." [GOC:dph, PMID:10341260]
synonym: "PPI" RELATED []
synonym: "pre-pulse inhibition" EXACT []
xref: Wikipedia:Prepulse_inhibition
is_a: GO:0032102 ! negative regulation of response to external stimulus
relationship: part_of GO:0001964 ! startle response

[Term]
id: GO:0060135
name: maternal process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0060136
name: embryonic process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007565 ! female pregnancy
relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0060137
name: maternal process involved in parturition
namespace: biological_process
def: "A reproductive process occurring in the mother that results in birth." [GOC:dph]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007567 ! parturition

[Term]
id: GO:0060138
name: fetal process involved in parturition
namespace: biological_process
def: "A reproductive process occurring in the embryo that results in birth." [GOC:dph]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007567 ! parturition
relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0060140
name: obsolete modulation by virus of syncytium formation via plasma membrane fusion
namespace: biological_process
def: "OBSOLETE. The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
comment: This term was obsoleted because it represents the same process as positive regulation of syncytium formation by virus ; GO:0060141.
is_obsolete: true
replaced_by: GO:0060141

[Term]
id: GO:0060141
name: symbiont-mediated induction of syncytium formation
namespace: biological_process
def: "A process in which a symbiont initiates, promotes, or enhances the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual host cells. Syncytia are produced by viruses that are able to fuse directly at the cell surface without requiring endocytosis." [GOC:dph]
synonym: "positive regulation of syncytium formation by virus" EXACT []
synonym: "syncytium formation induced by viral infection" EXACT [VZ:5957]
xref: VZ:5957
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0060142
name: regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060143
name: positive regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060144
name: obsolete host cellular process involved in virus induced gene silencing
namespace: biological_process
def: "OBSOLETE. A cellular process occurring in the host cell that contributes to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes." [GOC:dph]
comment: The reason for obsoletion is there there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0060146
name: obsolete host gene silencing in virus induced gene silencing
namespace: biological_process
def: "OBSOLETE. The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection." [GOC:dph]
comment: The reason for obsoletion is there there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0060147
name: regulation of post-transcriptional gene silencing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
synonym: "regulation of posttranscriptional gene silencing" EXACT []
is_a: GO:0010468 ! regulation of gene expression
relationship: regulates GO:0016441 ! post-transcriptional gene silencing

[Term]
id: GO:0060148
name: positive regulation of post-transcriptional gene silencing
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
synonym: "positive regulation of posttranscriptional gene silencing" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0060147 ! regulation of post-transcriptional gene silencing
relationship: positively_regulates GO:0016441 ! post-transcriptional gene silencing

[Term]
id: GO:0060149
name: negative regulation of post-transcriptional gene silencing
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
synonym: "negative regulation of posttranscriptional gene silencing" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0060147 ! regulation of post-transcriptional gene silencing
relationship: negatively_regulates GO:0016441 ! post-transcriptional gene silencing

[Term]
id: GO:0060151
name: peroxisome localization
namespace: biological_process
def: "Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325]
synonym: "peroxisome localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0060152
name: microtubule-based peroxisome localization
namespace: biological_process
def: "The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325]
synonym: "microtubule-based peroxisome localisation" EXACT [GOC:mah]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0060151 ! peroxisome localization

[Term]
id: GO:0060153
name: obsolete perturbation by virus of host cell cycle progression
namespace: biological_process
def: "OBSOLETE. A process in which a virus interferes with the normal progression through the host cell cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph]
comment: This term was obsoleted because it represents the same process as symbiont-mediated perturbation of host cell cycle progression ; GO:0044071.
synonym: "modulation by virus of host cell cycle" RELATED []
synonym: "modulation of host cell cycle by virus" EXACT []
synonym: "regulation by virus of host cell cycle" EXACT []
synonym: "regulation of host cell cycle by virus" EXACT []
synonym: "viral process regulating host cell cycle" EXACT []
is_obsolete: true
replaced_by: GO:0044071

[Term]
id: GO:0060154
name: obsolete cellular process regulating host cell cycle in response to virus
namespace: biological_process
def: "OBSOLETE. Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph]
comment: The reason for obsoletion is that based on the definition, it is not clear that this process exists.
is_obsolete: true

[Term]
id: GO:0060155
name: platelet dense granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:dph, PMID:11487378]
synonym: "bull's eye body organization and biogenesis" RELATED []
synonym: "platelet dense body organization and biogenesis" RELATED []
synonym: "platelet dense granule organisation" EXACT [GOC:mah]
synonym: "platelet dense granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0060156
name: milk ejection reflex
namespace: biological_process
def: "A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:cjm, GOC:dph, GOC:mr, GOC:st]
synonym: "milk ejection" EXACT []
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue
is_a: GO:0060004 ! reflex
relationship: part_of GO:0007595 ! lactation

[Term]
id: GO:0060157
name: urinary bladder development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln, GOC:mr, PMID:11768524, PMID:18276178, PMID:538956]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0060158
name: phospholipase C-activating dopamine receptor signaling pathway
namespace: biological_process
def: "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914]
synonym: "activation of phospholipase C activity by dopamine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by dopamine receptor signalling pathway" RELATED [GOC:mah]
synonym: "dopamine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0007212 ! G protein-coupled dopamine receptor signaling pathway

[Term]
id: GO:0060159
name: regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0007212 ! G protein-coupled dopamine receptor signaling pathway

[Term]
id: GO:0060160
name: negative regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
relationship: negatively_regulates GO:0007212 ! G protein-coupled dopamine receptor signaling pathway

[Term]
id: GO:0060161
name: positive regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
relationship: positively_regulates GO:0007212 ! G protein-coupled dopamine receptor signaling pathway

[Term]
id: GO:0060162
name: negative regulation of phospholipase C-activating dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway." [GOC:dph, GOC:tb, PMID:15016423]
synonym: "negative regulation of dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of phospholipase C-activating dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway
is_a: GO:1900737 ! negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
relationship: negatively_regulates GO:0060158 ! phospholipase C-activating dopamine receptor signaling pathway

[Term]
id: GO:0060163
name: subpallium neuron fate commitment
namespace: biological_process
def: "The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon." [GOC:dph]
synonym: "subpallium neuronal precursor fate commitment" RELATED []
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0060164
name: regulation of timing of neuron differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron." [GOC:dph]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0048505 ! regulation of timing of cell differentiation

[Term]
id: GO:0060165
name: regulation of timing of subpallium neuron differentiation
namespace: biological_process
def: "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph]
is_a: GO:0060164 ! regulation of timing of neuron differentiation
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0060166
name: olfactory pit development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043584 ! nose development

[Term]
id: GO:0060167
name: regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0001973 ! G protein-coupled adenosine receptor signaling pathway

[Term]
id: GO:0060168
name: positive regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "positive regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway
relationship: positively_regulates GO:0001973 ! G protein-coupled adenosine receptor signaling pathway

[Term]
id: GO:0060169
name: negative regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "negative regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway
relationship: negatively_regulates GO:0001973 ! G protein-coupled adenosine receptor signaling pathway

[Term]
id: GO:0060170
name: ciliary membrane
namespace: cellular_component
alt_id: GO:0020017
def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial membrane" EXACT []
synonym: "cilium membrane" EXACT []
synonym: "flagellar membrane" NARROW []
synonym: "flagellum membrane" NARROW []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0060171
name: stereocilium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rph]
is_a: GO:0032589 ! neuron projection membrane
relationship: part_of GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0060172
name: astral microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0030953 ! astral microtubule organization

[Term]
id: GO:0060173
name: limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378]
synonym: "limb bud development" NARROW [GOC:dph]
synonym: "paired limb/fin development" EXACT []
xref: Wikipedia:Limb_development
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0060174
name: limb bud formation
namespace: biological_process
def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable." [GOC:dgh, GOC:dph]
synonym: "limb formation" EXACT []
synonym: "limbbud formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035108 ! limb morphogenesis

[Term]
id: GO:0060175
name: brain-derived neurotrophic factor receptor activity
namespace: molecular_function
def: "Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:dph]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand BDNF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "BDNF receptor activity" RELATED [GOC:dph]
synonym: "BDNF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "brain-derived neurotrophic factor-activated receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
is_a: GO:0005030 ! neurotrophin receptor activity

[Term]
id: GO:0060176
name: regulation of aggregation involved in sorocarp development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:dph, GOC:tb]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0031152 ! aggregation involved in sorocarp development

[Term]
id: GO:0060177
name: regulation of angiotensin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." [GOC:dph, GOC:tb]
synonym: "regulation of angiotensin metabolism" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process

[Term]
id: GO:0060178
name: regulation of exocyst localization
namespace: biological_process
def: "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:dph, GOC:tb]
synonym: "regulation of exocyst localisation" EXACT [GOC:mah]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0051601 ! exocyst localization

[Term]
id: GO:0060179
name: male mating behavior
namespace: biological_process
def: "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0060180
name: female mating behavior
namespace: biological_process
def: "The specific behavior of a female organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0060182
name: apelin receptor activity
namespace: molecular_function
def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0060183
name: apelin receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by apelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:dph]
synonym: "apelin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0060184
name: cell cycle switching
namespace: biological_process
def: "The process in which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0060185
name: outer ear unfolding
namespace: biological_process
def: "The opening and spreading out of the outer ear." [GOC:dph]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0042473 ! outer ear morphogenesis

[Term]
id: GO:0060186
name: outer ear emergence
namespace: biological_process
def: "The growth of the outer ear." [GOC:dph]
synonym: "ear elevation" RELATED [GOC:dph]
synonym: "ear extroversion" RELATED [GOC:dph]
synonym: "outer ear growth" RELATED [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0042473 ! outer ear morphogenesis

[Term]
id: GO:0060187
name: cell pole
namespace: cellular_component
def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph]
comment: Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broad range of cell shapes including spherical and cuboidal.
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0060188
name: regulation of protein desumoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060189
name: positive regulation of protein desumoylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0060188 ! regulation of protein desumoylation
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
relationship: positively_regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060190
name: negative regulation of protein desumoylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0060188 ! regulation of protein desumoylation
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
relationship: negatively_regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060191
name: regulation of lipase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0060192
name: negative regulation of lipase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0060193
name: positive regulation of lipase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0060194
name: regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:jp, GOC:tb, PMID:18075583]
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060195
name: negative regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583]
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
is_a: GO:0060194 ! regulation of antisense RNA transcription
relationship: negatively_regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060196
name: positive regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:0060194 ! regulation of antisense RNA transcription
relationship: positively_regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060197
name: cloacal septation
namespace: biological_process
def: "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development." [GOC:dph, GOC:st]
synonym: "cloaca septation" EXACT [GOC:cjm]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0035844 ! cloaca development

[Term]
id: GO:0060198
name: clathrin-sculpted vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release." [GOC:dph]
synonym: "clathrin sculpted vesicle" EXACT [GOC:sl]
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0060199
name: clathrin-sculpted glutamate transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate." [GOC:dph]
synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle" EXACT []
synonym: "clathrin sculpted glutamate transport vesicle" EXACT [GOC:sl]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin-sculpted vesicle

[Term]
id: GO:0060200
name: clathrin-sculpted acetylcholine transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph]
synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle" EXACT []
synonym: "clathrin sculpted acetylcholine transport vesicle" EXACT [GOC:sl]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin-sculpted vesicle

[Term]
id: GO:0060201
name: clathrin-sculpted acetylcholine transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle." [GOC:dph]
synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "clathrin sculpted acetylcholine transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle

[Term]
id: GO:0060202
name: clathrin-sculpted acetylcholine transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted acetylcholine transport vesicle." [GOC:dph]
synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen" EXACT []
synonym: "clathrin sculpted acetylcholine transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle

[Term]
id: GO:0060203
name: clathrin-sculpted glutamate transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle." [GOC:dph]
synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "clathrin sculpted glutamate transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle

[Term]
id: GO:0060204
name: clathrin-sculpted glutamate transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted glutamate transport vesicle." [GOC:dph]
synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen" EXACT []
synonym: "clathrin sculpted glutamate transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle

[Term]
id: GO:0060205
name: cytoplasmic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]
synonym: "cytoplasmic membrane-bounded vesicle lumen" RELATED []
synonym: "cytoplasmic membrane-enclosed vesicle lumen" RELATED []
is_a: GO:0031983 ! vesicle lumen
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0060206
name: estrous cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0060207
name: diestrus
namespace: biological_process
def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060208
name: proestrus
namespace: biological_process
def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060209
name: estrus
namespace: biological_process
def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "oestrus" EXACT []
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060210
name: metestrus
namespace: biological_process
def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060211
name: regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "regulation of 3' to 5' mRNA deadenylation" RELATED []
synonym: "regulation of mRNA deadenylation" RELATED []
synonym: "regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0061013 ! regulation of mRNA catabolic process
relationship: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060212
name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "negative regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening
is_a: GO:1900152 ! negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
relationship: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060213
name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "positive regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
relationship: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060214
name: endocardium formation
namespace: biological_process
def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003160 ! endocardium morphogenesis

[Term]
id: GO:0060215
name: primitive hemopoiesis
namespace: biological_process
def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
synonym: "primitive haematopoiesis" EXACT []
synonym: "primitive haemopoiesis" EXACT []
synonym: "primitive hematopoiesis" RELATED []
is_a: GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0060216
name: definitive hemopoiesis
namespace: biological_process
def: "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continuously provide erythroid, myeloid and lymphoid lineages throughout adulthood." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
synonym: "definitive haematopoiesis" RELATED []
synonym: "definitive haemopoiesis" EXACT []
synonym: "definitive hematopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis

[Term]
id: GO:0060217
name: hemangioblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, PMID:15378083, PMID:9670018]
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0060215 ! primitive hemopoiesis

[Term]
id: GO:0060218
name: hematopoietic stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083]
synonym: "haematopoietic stem cell differentiation" EXACT []
synonym: "haemopoietic stem cell differentiation" EXACT []
synonym: "hemopoietic stem cell differentiation" EXACT []
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
is_a: GO:0048863 ! stem cell differentiation

[Term]
id: GO:0060219
name: camera-type eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060220
name: camera-type eye photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye." [GOC:dph]
is_a: GO:0042706 ! eye photoreceptor cell fate commitment
relationship: part_of GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0060221
name: retinal rod cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0060222
name: regulation of retinal cone cell fate commitment
namespace: biological_process
def: "Any process that modulates the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph]
is_a: GO:0010453 ! regulation of cell fate commitment
relationship: regulates GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0060223
name: retinal rod cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment
relationship: part_of GO:0060221 ! retinal rod cell differentiation

[Term]
id: GO:0060224
name: regulation of retinal rod cell fate commitment
namespace: biological_process
def: "Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0060223 ! retinal rod cell fate commitment

[Term]
id: GO:0060225
name: positive regulation of retinal rod cell fate commitment
namespace: biological_process
def: "Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
is_a: GO:0060224 ! regulation of retinal rod cell fate commitment
relationship: positively_regulates GO:0060223 ! retinal rod cell fate commitment

[Term]
id: GO:0060226
name: negative regulation of retinal cone cell fate commitment
namespace: biological_process
def: "Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
is_a: GO:0060222 ! regulation of retinal cone cell fate commitment
relationship: negatively_regulates GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0060227
name: Notch signaling pathway involved in camera-type eye photoreceptor fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate." [GOC:dph]
synonym: "Notch signalling pathway involved in camera-type eye photoreceptor fate commitment" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment

[Term]
id: GO:0060228
name: phosphatidylcholine-sterol O-acyltransferase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase." [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615]
synonym: "LCAT activator activity" NARROW [GOC:tb]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0060229
name: lipase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0060230
name: lipoprotein lipase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:BHF, GOC:dph, GOC:tb, PMID:10727238]
is_a: GO:0060229 ! lipase activator activity

[Term]
id: GO:0060231
name: mesenchymal to epithelial transition
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl]
synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0060232
name: delamination
namespace: biological_process
def: "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion

[Term]
id: GO:0060233
name: oenocyte delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet." [GOC:dph]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0060234
name: neuroblast delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet." [GOC:dph]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0060235
name: lens induction in camera-type eye
namespace: biological_process
def: "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens." [GOC:dph, ISBN:0878932437]
is_a: GO:0031128 ! developmental induction
relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye

[Term]
id: GO:0060236
name: regulation of mitotic spindle organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mitotic spindle organisation" EXACT [GOC:mah]
synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0090224 ! regulation of spindle organization
relationship: regulates GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0060237
name: regulation of fungal-type cell wall organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:tb]
synonym: "regulation of fungal-type cell wall organisation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall organization and biogenesis" RELATED []
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: regulates GO:0031505 ! fungal-type cell wall organization

[Term]
id: GO:0060238
name: regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
relationship: regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion

[Term]
id: GO:0060239
name: positive regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of signal transduction involved in conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
relationship: positively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion

[Term]
id: GO:0060240
name: negative regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series signal transduction involved in conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion

[Term]
id: GO:0060241
name: lysozyme inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of lysozyme." [GOC:dph]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0060242
name: contact inhibition
namespace: biological_process
alt_id: GO:0060246
alt_id: GO:0060248
def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation." [GOC:dph, PMID:17376520]
synonym: "detection of cell density by contact stimulus" RELATED []
synonym: "detection of cell density by contact stimulus involved in contact inhibition" RELATED []
xref: Wikipedia:Contact_inhibition
is_a: GO:0060245 ! detection of cell density

[Term]
id: GO:0060243
name: negative regulation of cell growth involved in contact inhibition
namespace: biological_process
def: "The negative regulation of cell growth in response to increased cell density." [GOC:dph]
is_a: GO:0030308 ! negative regulation of cell growth
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060244
name: negative regulation of cell proliferation involved in contact inhibition
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell population proliferation
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060245
name: detection of cell density
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph]
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0060249
name: anatomical structure homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph]
synonym: "anatomical structure maintenance" EXACT [GOC:dph]
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0060250
name: germ-line stem-cell niche homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph]
synonym: "germ-line stem-cell niche maintenance" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of germ line stem cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ line stem-cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ-line stem cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ-line stem-cell niche" EXACT [GOC:dph]
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0060251
name: regulation of glial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060252
name: positive regulation of glial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
relationship: positively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060253
name: negative regulation of glial cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
relationship: negatively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060254
name: regulation of N-terminal protein palmitoylation
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:1903059 ! regulation of protein lipidation
relationship: regulates GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0060255
name: regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0060256
name: regulation of flocculation
namespace: biological_process
alt_id: GO:1900455
def: "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [PMID:10591965, PMID:15466424, PMID:16568252]
synonym: "regulation of flocculation via cell wall protein-carbohydrate interaction" RELATED []
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0000128 ! flocculation

[Term]
id: GO:0060257
name: negative regulation of flocculation
namespace: biological_process
alt_id: GO:1901134
def: "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb]
synonym: "negative regulation of coflocculation" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0060256 ! regulation of flocculation
relationship: negatively_regulates GO:0000128 ! flocculation

[Term]
id: GO:0060258
name: negative regulation of filamentous growth
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb]
is_a: GO:0010570 ! regulation of filamentous growth
is_a: GO:0045926 ! negative regulation of growth
relationship: negatively_regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0060259
name: regulation of feeding behavior
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0007631 ! feeding behavior

[Term]
id: GO:0060260
name: regulation of transcription initiation by RNA polymerase II
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "regulation of transcription initiation from RNA polymerase II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II
is_a: GO:2000142 ! regulation of DNA-templated transcription initiation
relationship: regulates GO:0006367 ! transcription initiation at RNA polymerase II promoter

[Term]
id: GO:0060261
name: positive regulation of transcription initiation by RNA polymerase II
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "positive regulation of transcription initiation from RNA polymerase II promoter" EXACT []
is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II
is_a: GO:0060260 ! regulation of transcription initiation by RNA polymerase II
is_a: GO:2000144 ! positive regulation of DNA-templated transcription initiation
relationship: positively_regulates GO:0006367 ! transcription initiation at RNA polymerase II promoter

[Term]
id: GO:0060262
name: negative regulation of N-terminal protein palmitoylation
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0060254 ! regulation of N-terminal protein palmitoylation
is_a: GO:1903060 ! negative regulation of protein lipidation
relationship: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0060263
name: regulation of respiratory burst
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060264
name: regulation of respiratory burst involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "regulation of respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060263 ! regulation of respiratory burst
relationship: regulates GO:0002536 ! respiratory burst involved in inflammatory response

[Term]
id: GO:0060265
name: positive regulation of respiratory burst involved in inflammatory response
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response
is_a: GO:0060267 ! positive regulation of respiratory burst
relationship: positively_regulates GO:0002536 ! respiratory burst involved in inflammatory response

[Term]
id: GO:0060266
name: negative regulation of respiratory burst involved in inflammatory response
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response
is_a: GO:0060268 ! negative regulation of respiratory burst
is_a: GO:0060284 ! regulation of cell development
relationship: negatively_regulates GO:0002536 ! respiratory burst involved in inflammatory response

[Term]
id: GO:0060267
name: positive regulation of respiratory burst
namespace: biological_process
def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060263 ! regulation of respiratory burst
relationship: positively_regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060268
name: negative regulation of respiratory burst
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060263 ! regulation of respiratory burst
relationship: negatively_regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060269
name: centripetally migrating follicle cell migration
namespace: biological_process
def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph]
is_a: GO:0007297 ! follicle cell of egg chamber migration

[Term]
id: GO:0060270
name: main body follicle cell migration
namespace: biological_process
def: "The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte." [GOC:dph]
is_a: GO:0007297 ! follicle cell of egg chamber migration

[Term]
id: GO:0060271
name: cilium assembly
namespace: biological_process
alt_id: GO:0042384
def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliogenesis" EXACT []
synonym: "cilium biogenesis" RELATED [GOC:mah]
synonym: "cilium formation" EXACT []
synonym: "cilium morphogenesis" RELATED []
synonym: "cilium organization" RELATED [GOC:dph]
synonym: "microtubule-based flagellum assembly" EXACT []
is_a: GO:0044782 ! cilium organization
is_a: GO:0070925 ! organelle assembly
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0060272
name: embryonic skeletal joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton." [GOC:bf, GOC:BHF, GOC:dph, UBERON:0000982]
is_a: GO:0048704 ! embryonic skeletal system morphogenesis
relationship: part_of GO:0072498 ! embryonic skeletal joint development

[Term]
id: GO:0060273
name: crying behavior
namespace: biological_process
def: "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli." [GOC:dph]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0060274
name: maintenance of stationary phase
namespace: biological_process
def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment." [GOC:dph]
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0060275
name: maintenance of stationary phase in response to starvation
namespace: biological_process
def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment." [GOC:dph]
is_a: GO:0042594 ! response to starvation
is_a: GO:0060274 ! maintenance of stationary phase

[Term]
id: GO:0060276
name: maintenance of stationary phase in response to toxin
namespace: biological_process
def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment." [GOC:dph]
is_a: GO:0060274 ! maintenance of stationary phase
relationship: part_of GO:0009636 ! response to toxic substance

[Term]
id: GO:0060277
name: obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:0060278
name: regulation of ovulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0030728 ! ovulation

[Term]
id: GO:0060279
name: positive regulation of ovulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060278 ! regulation of ovulation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0030728 ! ovulation

[Term]
id: GO:0060280
name: negative regulation of ovulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060278 ! regulation of ovulation
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0030728 ! ovulation

[Term]
id: GO:0060281
name: regulation of oocyte development
namespace: biological_process
def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318]
is_a: GO:1905879 ! regulation of oogenesis
relationship: regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060282
name: positive regulation of oocyte development
namespace: biological_process
def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060283
name: negative regulation of oocyte development
namespace: biological_process
def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060284
name: regulation of cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0048468 ! cell development

[Term]
id: GO:0060285
name: cilium-dependent cell motility
namespace: biological_process
alt_id: GO:0071974
def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent.
synonym: "ciliary cell motility" RELATED []
synonym: "cilium cell motility" EXACT []
synonym: "microtubule-based flagellar cell motility" EXACT []
is_a: GO:0001539 ! cilium or flagellum-dependent cell motility

[Term]
id: GO:0060286
name: obsolete flagellar cell motility
namespace: biological_process
def: "OBSOLETE. Cell motility due to the motion of one or more flagella." [GOC:dgh, GOC:dph, GOC:mlg]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "flagellar cell motility" EXACT []
is_obsolete: true
consider: GO:0060285
consider: GO:0071973

[Term]
id: GO:0060287
name: epithelial cilium movement involved in determination of left/right asymmetry
namespace: biological_process
def: "The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579]
synonym: "cilium movement involved in determinationof L/R asymmetry" EXACT []
synonym: "Kuppfer's vesicle cilium movement involved in determination of left/right asymmetry" NARROW [GOC:cilia]
synonym: "nodal cilium movement involved in determination of left/right asymmetry" NARROW [GOC:cilia]
is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement
relationship: part_of GO:0007368 ! determination of left/right symmetry

[Term]
id: GO:0060288
name: formation of a compartment boundary
namespace: biological_process
def: "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
synonym: "compartment boundary formation" EXACT []
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007386 ! compartment pattern specification

[Term]
id: GO:0060289
name: compartment boundary maintenance
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0007386 ! compartment pattern specification

[Term]
id: GO:0060290
name: transdifferentiation
namespace: biological_process
def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GOC:dph, GOC:kmv]
xref: Wikipedia:Transdifferentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0060291
name: long-term synaptic potentiation
namespace: biological_process
def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]
synonym: "long-term potentiation" BROAD [GOC:dph]
synonym: "LTP" RELATED [GOC:dph]
is_a: GO:0048167 ! regulation of synaptic plasticity
is_a: GO:0050806 ! positive regulation of synaptic transmission

[Term]
id: GO:0060292
name: long-term synaptic depression
namespace: biological_process
def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]
synonym: "long term depression" BROAD [GOC:dph]
synonym: "long term synaptic depression" EXACT []
synonym: "LTD" RELATED [GOC:dph]
is_a: GO:0048167 ! regulation of synaptic plasticity
is_a: GO:0050805 ! negative regulation of synaptic transmission

[Term]
id: GO:0060293
name: germ plasm
namespace: cellular_component
def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph]
xref: Wikipedia:Germ_plasm
is_a: GO:0045495 ! pole plasm

[Term]
id: GO:0060294
name: cilium movement involved in cell motility
namespace: biological_process
def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
relationship: part_of GO:0060285 ! cilium-dependent cell motility

[Term]
id: GO:0060295
name: regulation of cilium movement involved in cell motility
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
relationship: regulates GO:0060294 ! cilium movement involved in cell motility

[Term]
id: GO:0060296
name: regulation of cilium beat frequency involved in ciliary motility
namespace: biological_process
def: "Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0003356 ! regulation of cilium beat frequency
is_a: GO:0060295 ! regulation of cilium movement involved in cell motility
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0060297
name: regulation of sarcomere organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0110020 ! regulation of actomyosin structure organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060298
name: positive regulation of sarcomere organization
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060299
name: negative regulation of sarcomere organization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060300
name: regulation of cytokine activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:0060301
name: positive regulation of cytokine activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060300 ! regulation of cytokine activity
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:2000273 ! positive regulation of signaling receptor activity

[Term]
id: GO:0060302
name: negative regulation of cytokine activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060300 ! regulation of cytokine activity
is_a: GO:1900121 ! negative regulation of receptor binding

[Term]
id: GO:0060303
name: obsolete regulation of nucleosome density
namespace: biological_process
def: "OBSOLETE. Any process that modulates the number of nucleosomes in a given region of a chromosome." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a readout and in some cases a phenotype, and the term can be misconstrued for chromatin compaction.
is_obsolete: true
consider: GO:0140750

[Term]
id: GO:0060304
name: regulation of phosphatidylinositol dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol." [GOC:dph, GOC:tb]
synonym: "regulation of phosphoinositide dephosphorylation" EXACT []
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: regulates GO:0046856 ! phosphatidylinositol dephosphorylation

[Term]
id: GO:0060305
name: regulation of cell diameter
namespace: biological_process
def: "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb]
synonym: "regulation of cell width" BROAD [GOC:dph, GOC:tb]
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0060306
name: regulation of membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0086009 ! membrane repolarization

[Term]
id: GO:0060307
name: regulation of ventricular cardiac muscle cell membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiomyocyte membrane repolarization" EXACT []
synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization
relationship: regulates GO:0099625 ! ventricular cardiac muscle cell membrane repolarization

[Term]
id: GO:0060308
name: GTP cyclohydrolase I regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0060309
name: elastin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "elastin breakdown" EXACT []
synonym: "elastin catabolism" EXACT []
synonym: "elastin degradation" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0051541 ! elastin metabolic process

[Term]
id: GO:0060310
name: regulation of elastin catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of elastin breakdown" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of elastin catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of elastin degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
relationship: regulates GO:0060309 ! elastin catabolic process

[Term]
id: GO:0060311
name: negative regulation of elastin catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down-regulation of elastin catabolic process" EXACT []
synonym: "negative regulation of elastin breakdown" EXACT []
synonym: "negative regulation of elastin catabolism" EXACT []
synonym: "negative regulation of elastin degradation" EXACT []
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0060310 ! regulation of elastin catabolic process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process
relationship: negatively_regulates GO:0060309 ! elastin catabolic process

[Term]
id: GO:0060312
name: regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of blood vessel remodelling" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0060313
name: negative regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of blood vessel remodelling" EXACT []
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060312 ! regulation of blood vessel remodeling
relationship: negatively_regulates GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0060314
name: regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:0060315
name: negative regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol
is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:2001258 ! negative regulation of cation channel activity

[Term]
id: GO:0060316
name: positive regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol
is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:0060317
name: cardiac epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351]
synonym: "heart epithelial to mesenchymal transition" EXACT []
is_a: GO:0001837 ! epithelial to mesenchymal transition
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0060318
name: definitive erythrocyte differentiation
namespace: biological_process
def: "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph]
synonym: "definitive erythropoiesis" EXACT []
synonym: "definitive RBC differentiation" EXACT [CL:0000232]
synonym: "definitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
relationship: part_of GO:0060216 ! definitive hemopoiesis

[Term]
id: GO:0060319
name: primitive erythrocyte differentiation
namespace: biological_process
def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph]
synonym: "primitive erythropoiesis" EXACT [GOC:add, GOC:dph]
synonym: "primitive RBC differentiation" EXACT [CL:0000232]
synonym: "primitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
relationship: part_of GO:0060215 ! primitive hemopoiesis

[Term]
id: GO:0060320
name: rejection of self pollen
namespace: biological_process
def: "The recognition and rejection of self pollen by cells in the stigma, mediated by the sharing and interaction of the single locus incompatibility haplotypes." [GOC:dph, GOC:tb, PMID:34848142]
synonym: "self-incompatibility" RELATED []
is_a: GO:0048544 ! recognition of pollen

[Term]
id: GO:0060321
name: acceptance of pollen
namespace: biological_process
def: "The recognition and acceptance of pollen by cells in the stigma, mediated by the sharing and interaction of the single locus incompatibility haplotypes." [GOC:dph, GOC:tb]
synonym: "acceptance of non-self pollen" RELATED [GOC:dph, GOC:tb]
synonym: "acceptance of self pollen" NARROW [GOC:dph, GOC:tb]
synonym: "self-compatibility" RELATED []
is_a: GO:0048544 ! recognition of pollen
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0060322
name: head development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0060323
name: head morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0010171 ! body morphogenesis
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0060324
name: face development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0060325
name: face morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060323 ! head morphogenesis
relationship: part_of GO:0060324 ! face development

[Term]
id: GO:0060326
name: cell chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]
is_a: GO:0006935 ! chemotaxis
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0060327
name: cytoplasmic actin-based contraction involved in cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0048870 ! cell motility

[Term]
id: GO:0060328
name: cytoplasmic actin-based contraction involved in forward cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell." [GOC:dph]
synonym: "cytoplasmic actin-based contraction involved in forward cell locomotion" RELATED []
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility

[Term]
id: GO:0060329
name: cytoplasmic actin-based contraction involved in rearward cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell." [GOC:dph]
synonym: "cytoplasmic actin-based contraction involved in rearward cell locomotion" RELATED []
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility

[Term]
id: GO:0060330
name: regulation of response to type II interferon
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "regulation of response to gamma-interferon" RELATED []
synonym: "regulation of response to immune interferon" EXACT []
synonym: "regulation of response to interferon-gamma" BROAD []
synonym: "regulation of response to type II IFN" EXACT []
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: regulates GO:0034341 ! response to type II interferon

[Term]
id: GO:0060331
name: negative regulation of response to type II interferon
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "negative regulation of response to gamma-interferon" RELATED []
synonym: "negative regulation of response to immune interferon" EXACT []
synonym: "negative regulation of response to interferon-gamma" EXACT []
synonym: "negative regulation of response to type II IFN" BROAD []
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0060330 ! regulation of response to type II interferon
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
relationship: negatively_regulates GO:0034341 ! response to type II interferon

[Term]
id: GO:0060332
name: positive regulation of response to type II interferon
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "positive regulation of response to gamma-interferon" RELATED []
synonym: "positive regulation of response to immune interferon" EXACT []
synonym: "positive regulation of response to interferon-gamma" EXACT []
synonym: "positive regulation of response to type II IFN" BROAD []
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0060330 ! regulation of response to type II interferon
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
relationship: positively_regulates GO:0034341 ! response to type II interferon

[Term]
id: GO:0060333
name: type II interferon-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling, PMID:28901902]
synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "immune interferon signaling pathway" EXACT [GOC:dph]
synonym: "interferon-gamma-mediated signaling pathway" EXACT []
synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "type II IFN-mediated signaling pathway" EXACT []
is_a: GO:0140888 ! interferon-mediated signaling pathway
relationship: part_of GO:0071346 ! cellular response to type II interferon

[Term]
id: GO:0060334
name: regulation of type II interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway." [GOC:dph]
synonym: "regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "regulation of immune interferon signaling pathway" EXACT [GOC:dph]
synonym: "regulation of interferon-gamma-mediated signaling pathway" EXACT []
synonym: "regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0060330 ! regulation of response to type II interferon
relationship: regulates GO:0060333 ! type II interferon-mediated signaling pathway

[Term]
id: GO:0060335
name: positive regulation of type II interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway." [GOC:dph]
synonym: "positive regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "positive regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "positive regulation of interferon-gamma-mediated signaling pathway" BROAD [GOC:dph]
synonym: "positive regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of type II IFN-mediated pathway" BROAD [GOC:dph]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0060332 ! positive regulation of response to type II interferon
is_a: GO:0060334 ! regulation of type II interferon-mediated signaling pathway
relationship: positively_regulates GO:0060333 ! type II interferon-mediated signaling pathway

[Term]
id: GO:0060336
name: negative regulation of type II interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway." [GOC:dph]
synonym: "negative regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "negative regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "negative regulation of interferon-gamma-mediated signaling pathway" BROAD [GOC:dph]
synonym: "negative regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0060331 ! negative regulation of response to type II interferon
is_a: GO:0060334 ! regulation of type II interferon-mediated signaling pathway
relationship: negatively_regulates GO:0060333 ! type II interferon-mediated signaling pathway

[Term]
id: GO:0060337
name: type I interferon-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling, PMID:32464097]
synonym: "type I interferon signaling pathway" EXACT []
synonym: "type I interferon-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0140888 ! interferon-mediated signaling pathway
relationship: part_of GO:0071357 ! cellular response to type I interferon

[Term]
id: GO:0060338
name: regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway." [GOC:dph]
synonym: "regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0060337 ! type I interferon-mediated signaling pathway

[Term]
id: GO:0060339
name: negative regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway." [GOC:dph]
synonym: "negative regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway
relationship: negatively_regulates GO:0060337 ! type I interferon-mediated signaling pathway

[Term]
id: GO:0060340
name: positive regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway." [GOC:dph]
synonym: "positive regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway
relationship: positively_regulates GO:0060337 ! type I interferon-mediated signaling pathway

[Term]
id: GO:0060341
name: regulation of cellular localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]
synonym: "regulation of cellular localisation" EXACT [GOC:mah]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051641 ! cellular localization

[Term]
id: GO:0060342
name: photoreceptor inner segment membrane
namespace: cellular_component
def: "The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:dph]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0001917 ! photoreceptor inner segment

[Term]
id: GO:0060343
name: trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
synonym: "trabecula biogenesis" RELATED [GOC:dph]
synonym: "trabeculation" EXACT [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0061383 ! trabecula morphogenesis

[Term]
id: GO:0060344
name: liver trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "liver trabecula biogenesis" RELATED []
synonym: "liver trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0060345
name: spleen trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "spleen trabecula biogenesis" RELATED [GOC:dph]
synonym: "spleen trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0048536 ! spleen development

[Term]
id: GO:0060346
name: bone trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "bone trabecula biogenesis" RELATED [GOC:dph]
synonym: "bone trabeculation" EXACT [GOC:dph]
synonym: "skeletal trabecula biogenesis" RELATED [GOC:dph]
synonym: "skeletal trabecula formation" EXACT [GOC:dph]
synonym: "skeletal trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0061430 ! bone trabecula morphogenesis

[Term]
id: GO:0060347
name: heart trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "cardiac trabecula formation" EXACT [GOC:dph]
synonym: "cardiac trabeculation" EXACT [GOC:dph]
synonym: "heart trabecula biogenesis" RELATED [GOC:dph]
synonym: "heart trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0061384 ! heart trabecula morphogenesis

[Term]
id: GO:0060348
name: bone development
namespace: biological_process
def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0001501 ! skeletal system development

[Term]
id: GO:0060349
name: bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0060350
name: endochondral bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679]
is_a: GO:0060349 ! bone morphogenesis

[Term]
id: GO:0060351
name: cartilage development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph]
is_a: GO:0051216 ! cartilage development
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0060352
name: cell adhesion molecule production
namespace: biological_process
def: "The appearance of a cell adhesion molecule due to biosynthesis or secretion." [GOC:BHF, GOC:rl]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0060353
name: regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060354
name: negative regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0060353 ! regulation of cell adhesion molecule production
relationship: negatively_regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060355
name: positive regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060353 ! regulation of cell adhesion molecule production
relationship: positively_regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060357
name: obsolete regulation of L-leucine import
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is not specific enough relative to the localization of the substrate ; consider annotating to regulation of L-leucine import across plasma membrane ; GO:1905532.
synonym: "regulation of L-leucine import" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of L-leucine uptake" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of leucine import" BROAD []
synonym: "regulation of leucine uptake" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:1905532

[Term]
id: GO:0060358
name: obsolete negative regulation of L-leucine import
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency or extent of L-leucine import. L-leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is not specific enough relative to the localization of the substrate ; consider annotating to negative regulation of L-leucine import across plasma membrane ; GO:1905533.
synonym: "negative regulation of leucine import" BROAD []
is_obsolete: true
replaced_by: GO:1905533

[Term]
id: GO:0060359
name: response to ammonium ion
namespace: biological_process
alt_id: GO:1903717
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
synonym: "response to ammonia" EXACT []
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0060360
name: negative regulation of leucine import in response to ammonium ion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of leucine uptake in response to ammonium ion" EXACT []
is_a: GO:1905533 ! negative regulation of L-leucine import across plasma membrane
relationship: part_of GO:0071242 ! cellular response to ammonium ion

[Term]
id: GO:0060361
name: flight
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0060362
name: flight involved in flight behavior
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight." [GOC:dph]
is_a: GO:0031987 ! locomotion involved in locomotory behavior
is_a: GO:0060361 ! flight
relationship: part_of GO:0007629 ! flight behavior

[Term]
id: GO:0060363
name: cranial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between cranial bones is generated and organized." [GOC:dph, GOC:pr, GOC:sl]
is_a: GO:0097094 ! craniofacial suture morphogenesis

[Term]
id: GO:0060364
name: frontal suture morphogenesis
namespace: biological_process
def: "The process in which the frontal suture is generated and organized." [GOC:dph, GOC:sl]
synonym: "interfrontal suture morphogenesis" EXACT []
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060365
name: coronal suture morphogenesis
namespace: biological_process
def: "The process in which the coronal suture is generated and organized." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060366
name: lambdoid suture morphogenesis
namespace: biological_process
def: "The process in which the lambdoid suture is generated and organized." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060367
name: sagittal suture morphogenesis
namespace: biological_process
def: "The process in which the sagittal suture is generated and organized." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060368
name: regulation of Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway.." [GOC:dph, GOC:tb]
synonym: "regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway

[Term]
id: GO:0060369
name: positive regulation of Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway
relationship: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway

[Term]
id: GO:0060370
name: susceptibility to T cell mediated cytotoxicity
namespace: biological_process
def: "The process of causing a cell to become susceptible to T cell mediated cytotoxicity." [GOC:dph, GOC:tb]
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity

[Term]
id: GO:0060371
name: regulation of atrial cardiac muscle cell membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiac muscle cell depolarization" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiomyocyte membrane depolarization" EXACT []
is_a: GO:0003254 ! regulation of membrane depolarization

[Term]
id: GO:0060372
name: regulation of atrial cardiac muscle cell membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiomyocyte membrane repolarization" EXACT []
is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization
relationship: regulates GO:0099624 ! atrial cardiac muscle cell membrane repolarization

[Term]
id: GO:0060373
name: regulation of ventricular cardiac muscle cell membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiomyocyte membrane depolarization" EXACT []
synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003254 ! regulation of membrane depolarization

[Term]
id: GO:0060374
name: mast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0060375
name: regulation of mast cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060376
name: positive regulation of mast cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0060375 ! regulation of mast cell differentiation
relationship: positively_regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060377
name: negative regulation of mast cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0060375 ! regulation of mast cell differentiation
relationship: negatively_regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060378
name: regulation of brood size
namespace: biological_process
def: "Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:dph, GOC:tb]
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0060379
name: cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb]
synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb]
synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation
is_a: GO:0045445 ! myoblast differentiation

[Term]
id: GO:0060380
name: regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:1904742 ! regulation of telomeric DNA binding

[Term]
id: GO:0060381
name: positive regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "positive regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0060380 ! regulation of single-stranded telomeric DNA binding
is_a: GO:1904744 ! positive regulation of telomeric DNA binding

[Term]
id: GO:0060382
name: regulation of DNA strand elongation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:mah]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0022616 ! DNA strand elongation

[Term]
id: GO:0060383
name: positive regulation of DNA strand elongation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:mah]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0060382 ! regulation of DNA strand elongation
relationship: positively_regulates GO:0022616 ! DNA strand elongation

[Term]
id: GO:0060384
name: innervation
namespace: biological_process
def: "The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue." [GOC:dph, GOC:sart]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0021675 ! nerve development

[Term]
id: GO:0060385
name: axonogenesis involved in innervation
namespace: biological_process
def: "The neurite development process that generates a long process of a neuron, as it invades a target tissue." [GOC:dph, GOC:sart]
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0060384 ! innervation

[Term]
id: GO:0060386
name: synapse assembly involved in innervation
namespace: biological_process
def: "The assembly of a synapse within a target tissue in which a nerve is invading." [GOC:dph, GOC:pr, GOC:sart]
synonym: "synapse biogenesis involved in innervation" EXACT []
synonym: "synaptogenesis involved in innervation" EXACT []
is_a: GO:0007416 ! synapse assembly
relationship: part_of GO:0060384 ! innervation

[Term]
id: GO:0060387
name: fertilization envelope
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release." [GOC:dph, ISBN:0878932437]
synonym: "fertilization membrane" RELATED []
is_a: GO:0035805 ! egg coat

[Term]
id: GO:0060388
name: vitelline envelope
namespace: cellular_component
def: "A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization." [GOC:dph, ISBN:0878932437]
synonym: "fertilization membrane" RELATED []
is_a: GO:0035805 ! egg coat

[Term]
id: GO:0060389
name: obsolete pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor." [GOC:dph, ISBN:3527303782]
comment: This term was obsoleted because it represents a molecular function.
synonym: "pathway restricted SMAD protein phosphorylation" EXACT [GOC:rl]
synonym: "R-SMAD protein phosphorylation" EXACT [GOC:rl]
synonym: "receptor regulated SMAD protein phosphorylation" EXACT [GOC:rl]
synonym: "receptor-regulated SMAD protein phosphorylation" EXACT [GOC:rl]
is_obsolete: true
consider: GO:0004672
consider: GO:0060391
consider: GO:0060395

[Term]
id: GO:0060390
name: regulation of SMAD protein signal transduction
namespace: biological_process
alt_id: GO:0007184
def: "Any process that modulates the rate, frequency or extent of SMAD protein signal transduction." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of SMAD protein nuclear translocation" NARROW [GOC:mah]
synonym: "SMAD protein import into nucleus" NARROW []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0060395 ! SMAD protein signal transduction

[Term]
id: GO:0060391
name: positive regulation of SMAD protein signal transduction
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of SMAD protein signal transduction." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of SMAD protein import into nucleus" NARROW []
synonym: "positive regulation of SMAD protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0060390 ! regulation of SMAD protein signal transduction
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0060395 ! SMAD protein signal transduction

[Term]
id: GO:0060392
name: negative regulation of SMAD protein signal transduction
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of SMAD protein import into nucleus" NARROW []
synonym: "negative regulation of SMAD protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0060390 ! regulation of SMAD protein signal transduction
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0060395 ! SMAD protein signal transduction

[Term]
id: GO:0060393
name: obsolete regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0019887
consider: GO:0060390

[Term]
id: GO:0060394
name: obsolete negative regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0004860
consider: GO:0060392

[Term]
id: GO:0060395
name: SMAD protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF]
comment: Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.
is_a: GO:0141124 ! intracellular signaling cassette
relationship: part_of GO:0007178 ! cell surface receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0060396
name: growth hormone receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442]
synonym: "cellular response to growth hormone" RELATED [GOC:dph]
synonym: "GH receptor signaling pathway" RELATED [GOC:dph]
synonym: "growth hormone receptor signalling pathway" EXACT [GOC:dph]
is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0071378 ! cellular response to growth hormone stimulus

[Term]
id: GO:0060397
name: growth hormone receptor signaling pathway via JAK-STAT
namespace: biological_process
def: "The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:BHF, GOC:dph, PMID:11445442]
synonym: "JAK-STAT cascade involved in growth hormone signalling pathway" EXACT [GOC:dph]
is_a: GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060398
name: regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph]
synonym: "regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060399
name: positive regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph]
synonym: "positive regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway
relationship: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060400
name: negative regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:dph]
synonym: "negative regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway
relationship: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060402
name: calcium ion transport into cytosol
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into the cytosol." [GOC:dph, GOC:tb]
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
is_a: GO:0097553 ! calcium ion transmembrane import into cytosol

[Term]
id: GO:0060404
name: axonemal microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010938 ! cytoplasmic microtubule depolymerization
is_a: GO:0061523 ! cilium disassembly

[Term]
id: GO:0060405
name: regulation of penile erection
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0043084 ! penile erection

[Term]
id: GO:0060406
name: positive regulation of penile erection
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060405 ! regulation of penile erection
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0043084 ! penile erection

[Term]
id: GO:0060407
name: negative regulation of penile erection
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060405 ! regulation of penile erection
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0043084 ! penile erection

[Term]
id: GO:0060408
name: regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060409
name: positive regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
relationship: positively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060410
name: negative regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
relationship: negatively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060411
name: cardiac septum morphogenesis
namespace: biological_process
alt_id: GO:0003280
def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart]
synonym: "heart septum morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003279 ! cardiac septum development

[Term]
id: GO:0060412
name: ventricular septum morphogenesis
namespace: biological_process
def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph]
synonym: "interventricular septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003281 ! ventricular septum development

[Term]
id: GO:0060413
name: atrial septum morphogenesis
namespace: biological_process
alt_id: GO:0003287
def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart]
synonym: "interatrial septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003283 ! atrial septum development

[Term]
id: GO:0060414
name: aorta smooth muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0035909 ! aorta morphogenesis
relationship: part_of GO:0048745 ! smooth muscle tissue development

[Term]
id: GO:0060415
name: muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048644 ! muscle organ morphogenesis

[Term]
id: GO:0060416
name: response to growth hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:BHF, GOC:dph]
synonym: "response to growth hormone stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0060417
name: yolk
namespace: cellular_component
def: "The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo." [GOC:dph, GOC:tb, PMID:18046696]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0060418
name: yolk plasma
namespace: cellular_component
def: "Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:dph, GOC:tb, PMID:18046696]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0060417 ! yolk

[Term]
id: GO:0060419
name: heart growth
namespace: biological_process
def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060420
name: regulation of heart growth
namespace: biological_process
def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0060419 ! heart growth

[Term]
id: GO:0060421
name: positive regulation of heart growth
namespace: biological_process
def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0046622 ! positive regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
relationship: positively_regulates GO:0060419 ! heart growth

[Term]
id: GO:0060422
name: peptidyl-dipeptidase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb]
is_a: GO:0030414 ! peptidase inhibitor activity

[Term]
id: GO:0060423
name: foregut regionalization
namespace: biological_process
def: "The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:dph, GOC:mtg_lung]
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0060424
name: lung field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung]
synonym: "lung specification" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0010092 ! specification of animal organ identity
is_a: GO:0060423 ! foregut regionalization
relationship: part_of GO:0060431 ! primary lung bud formation

[Term]
id: GO:0060425
name: lung morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060426
name: lung vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060427
name: lung connective tissue development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary connective tissue development" EXACT []
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060428
name: lung epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060429
name: epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]
subset: goslim_drosophila
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0060430
name: lung saccule development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells." [GOC:dph, GOC:mtg_lung]
synonym: "lung saccular development" BROAD [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048286 ! lung alveolus development

[Term]
id: GO:0060431
name: primary lung bud formation
namespace: biological_process
def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung]
synonym: "lung formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! animal organ formation
is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis
is_a: GO:0060572 ! morphogenesis of an epithelial bud

[Term]
id: GO:0060432
name: lung pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate." [GOC:dph]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060433
name: bronchus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0030323 ! respiratory tube development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060434
name: bronchus morphogenesis
namespace: biological_process
def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0060433 ! bronchus development

[Term]
id: GO:0060435
name: bronchiole development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung]
is_a: GO:0030323 ! respiratory tube development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060436
name: bronchiole morphogenesis
namespace: biological_process
def: "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0060435 ! bronchiole development

[Term]
id: GO:0060437
name: lung growth
namespace: biological_process
def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060438
name: trachea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060439
name: trachea morphogenesis
namespace: biological_process
def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0060438 ! trachea development

[Term]
id: GO:0060440
name: trachea formation
namespace: biological_process
def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048645 ! animal organ formation
relationship: part_of GO:0060439 ! trachea morphogenesis

[Term]
id: GO:0060441
name: epithelial tube branching involved in lung morphogenesis
namespace: biological_process
def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung]
synonym: "lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
relationship: part_of GO:0060425 ! lung morphogenesis

[Term]
id: GO:0060442
name: branching involved in prostate gland morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph]
synonym: "prostate branching" RELATED [GOC:dph]
synonym: "prostate gland branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium

[Term]
id: GO:0060443
name: mammary gland morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060444
name: branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph]
synonym: "mammary gland branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060445
name: branching involved in salivary gland morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the salivary gland is generated and organized." [GOC:dph]
is_a: GO:0061138 ! morphogenesis of a branching epithelium
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060446
name: branching involved in open tracheal system development
namespace: biological_process
def: "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0060447
name: bud outgrowth involved in lung branching
namespace: biological_process
def: "The process in which a region of the lung epithelium initiates an outgrowth." [GOC:dph, GOC:mtg_lung]
synonym: "bud formation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060448
name: dichotomous subdivision of terminal units involved in lung branching
namespace: biological_process
def: "The process in which a lung bud bifurcates." [GOC:dph, GOC:mtg_lung]
synonym: "bud bifurcation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060449
name: bud elongation involved in lung branching
namespace: biological_process
def: "The process in which a bud in the lung grows out from the point where it is formed." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060450
name: positive regulation of hindgut contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:0060456 ! positive regulation of digestive system process
relationship: positively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060451
name: negative regulation of hindgut contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0060457 ! negative regulation of digestive system process
relationship: negatively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060452
name: positive regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb]
is_a: GO:0045823 ! positive regulation of heart contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
relationship: positively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0060453
name: regulation of gastric acid secretion
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060454
name: positive regulation of gastric acid secretion
namespace: biological_process
def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060456 ! positive regulation of digestive system process
relationship: positively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060455
name: negative regulation of gastric acid secretion
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060457 ! negative regulation of digestive system process
relationship: negatively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060456
name: positive regulation of digestive system process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060457
name: negative regulation of digestive system process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060458
name: right lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0030324 ! lung development

[Term]
id: GO:0060459
name: left lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "left pulmonary development" EXACT [GOC:dph]
is_a: GO:0030324 ! lung development

[Term]
id: GO:0060460
name: left lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph]
is_a: GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060459 ! left lung development

[Term]
id: GO:0060461
name: right lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060458 ! right lung development

[Term]
id: GO:0060462
name: lung lobe development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060463
name: lung lobe morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060462 ! lung lobe development

[Term]
id: GO:0060464
name: lung lobe formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060463 ! lung lobe morphogenesis

[Term]
id: GO:0060465
name: pharynx development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk]
synonym: "pharyngeal development" RELATED []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0060466
name: activation of meiosis involved in egg activation
namespace: biological_process
def: "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation." [GOC:dph]
synonym: "reactivation of meiosis after fertilization" NARROW [GOC:dph]
synonym: "resumption of meiosis involved in egg activation" EXACT [GOC:dph]
is_a: GO:0090427 ! activation of meiosis
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060467
name: negative regulation of fertilization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph]
is_a: GO:0080154 ! regulation of fertilization
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0009566 ! fertilization

[Term]
id: GO:0060468
name: prevention of polyspermy
namespace: biological_process
def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph]
synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph]
synonym: "polyspermy block" EXACT [GOC:dph]
is_a: GO:0060467 ! negative regulation of fertilization
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060469
name: obsolete positive regulation of transcription involved in egg activation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation." [GOC:dph]
comment: This term was obsoleted because it represents GO-CAM model.
synonym: "activation of the egg genome" RELATED [GOC:dph]
synonym: "activation of the maternal genome" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0060470
name: positive regulation of cytosolic calcium ion concentration involved in egg activation
namespace: biological_process
def: "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg." [GOC:dph]
synonym: "elevation of cytosolic calcium ion concentration involved in egg activation" EXACT []
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060471
name: cortical granule exocytosis
namespace: biological_process
def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy." [GOC:dph]
synonym: "cortical granule release" RELATED [GOC:dph]
synonym: "cortical reaction" RELATED [PMID:22088197]
is_a: GO:0017156 ! calcium-ion regulated exocytosis
relationship: part_of GO:0060468 ! prevention of polyspermy

[Term]
id: GO:0060472
name: positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol." [GOC:dph]
synonym: "positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration" EXACT []
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0060470 ! positive regulation of cytosolic calcium ion concentration involved in egg activation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0060471 ! cortical granule exocytosis

[Term]
id: GO:0060473
name: cortical granule
namespace: cellular_component
def: "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy." [GOC:dph]
synonym: "cortical vesicle" RELATED [GOC:dph]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0060474
name: positive regulation of flagellated sperm motility involved in capacitation
namespace: biological_process
def: "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence." [GOC:cilia, GOC:dph, GOC:krc]
synonym: "positive regulation of sperm motility involved in capacitation" RELATED []
is_a: GO:0022414 ! reproductive process
is_a: GO:1902093 ! positive regulation of flagellated sperm motility
relationship: part_of GO:0048240 ! sperm capacitation

[Term]
id: GO:0060475
name: obsolete positive regulation of actin filament polymerization involved in acrosome reaction
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction." [GOC:dph]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "positive regulation of actin polymerization involved in acrosome reaction" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0060476
name: protein localization involved in acrosome reaction
namespace: biological_process
def: "The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." [GOC:dph]
synonym: "protein localisation involved in acrosome reaction" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization
is_a: GO:0030029 ! actin filament-based process
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060477
name: obsolete peptidyl-serine phosphorylation involved in acrosome reaction
namespace: biological_process
def: "OBSOLETE. The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine that is part of the acrosome reaction." [GOC:dph]
comment: The reason for obsoletion is that this term does not represent a specific process.
is_obsolete: true

[Term]
id: GO:0060478
name: acrosomal vesicle exocytosis
namespace: biological_process
def: "The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction." [GOC:dph]
synonym: "acrosomal granule exocytosis" RELATED [GOC:dph]
synonym: "acrosome exocytosis" EXACT [GOC:dph]
is_a: GO:0017156 ! calcium-ion regulated exocytosis
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060479
name: lung cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060480
name: lung goblet cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary goblet cell differentiation" EXACT []
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0061140 ! lung secretory cell differentiation
relationship: part_of GO:0060481 ! lobar bronchus epithelium development

[Term]
id: GO:0060481
name: lobar bronchus epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060428 ! lung epithelium development
relationship: part_of GO:0060482 ! lobar bronchus development

[Term]
id: GO:0060482
name: lobar bronchus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060433 ! bronchus development

[Term]
id: GO:0060483
name: lobar bronchus mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060484 ! lung-associated mesenchyme development
relationship: part_of GO:0060482 ! lobar bronchus development

[Term]
id: GO:0060484
name: lung-associated mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung." [GOC:dph, GOC:mtg_lung]
synonym: "lung mesenchyme development" EXACT [GOC:dph]
synonym: "pulmonary mesenchyme development" EXACT [GOC:dph]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060485
name: mesenchyme development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph]
synonym: "mesenchymal development" EXACT [GOC:dph]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0060486
name: club cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung, PMID:28144783]
synonym: "Clara cell differentiation" EXACT [PMID:28144783]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0060487
name: lung epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph]
synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060479 ! lung cell differentiation
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060488
name: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
namespace: biological_process
def: "The process in which a lung bud bifurcates perpendicular to the plane of the previous bud." [GOC:dph, GOC:mtg_lung]
synonym: "perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching

[Term]
id: GO:0060489
name: planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
namespace: biological_process
def: "The process in which a lung bud bifurcates parallel to the plane of the previous bud." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching

[Term]
id: GO:0060490
name: lateral sprouting involved in lung morphogenesis
namespace: biological_process
def: "The process in which a branch forms along the side of the lung epithelial tube." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060601 ! lateral sprouting from an epithelium
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060491
name: regulation of cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb]
synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0030031 ! cell projection assembly

[Term]
id: GO:0060492
name: lung induction
namespace: biological_process
def: "The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung." [GOC:dph]
is_a: GO:0001759 ! organ induction
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
relationship: positively_regulates GO:0060424 ! lung field specification

[Term]
id: GO:0060493
name: mesenchymal-endodermal cell signaling involved in lung induction
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud." [GOC:dph, GOC:mtg_lung]
synonym: "mesenchymal-endodermal cell signalling involved in lung induction" EXACT [GOC:mah]
is_a: GO:0060494 ! inductive mesenchymal-endodermal cell signaling
is_a: GO:0060496 ! mesenchymal-epithelial cell signaling involved in lung development
is_a: GO:0060497 ! mesenchymal-endodermal cell signaling
relationship: part_of GO:0060492 ! lung induction

[Term]
id: GO:0060494
name: inductive mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell." [GOC:dph, GOC:mtg_lung]
synonym: "inductive mesenchymal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0060495
name: cell-cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung]
synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060496
name: mesenchymal-epithelial cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling

[Term]
id: GO:0060497
name: mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph]
synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0060498
name: obsolete retinoic acid receptor signaling pathway involved in lung bud formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud." [GOC:dph, GOC:mtg_lung]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model.
synonym: "retinoic acid receptor signalling pathway involved in lung bud formation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0048384
consider: GO:0060431

[Term]
id: GO:0060499
name: obsolete fibroblast growth factor receptor signaling pathway involved in lung induction
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus." [GOC:dph, GOC:mtg_lung]
comment: The reason for obsoletion is that these are pre-composed terms that represent a cell-surface signaling pathway during some developmental process.
synonym: "fibroblast growth factor receptor signalling pathway involved in lung induction" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0060500
name: obsolete regulation of transcription from RNA polymerase II promoter involved in lung bud formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the initial primordium of the lung is formed." [GOC:dph, GOC:mtg_lung]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0060431

[Term]
id: GO:0060501
name: positive regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
relationship: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis

[Term]
id: GO:0060502
name: epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060503
name: bud dilation involved in lung branching
namespace: biological_process
def: "The process in which a bud in the lung increases radially." [GOC:dph]
synonym: "bud expansion" EXACT [GOC:dph]
is_a: GO:0003401 ! axis elongation
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060504
name: positive regulation of epithelial cell proliferation involved in lung bud dilation
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially." [GOC:dph]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis
is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis
relationship: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation

[Term]
id: GO:0060505
name: epithelial cell proliferation involved in lung bud dilation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud." [GOC:dph]
is_a: GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: part_of GO:0060503 ! bud dilation involved in lung branching

[Term]
id: GO:0060506
name: smoothened signaling pathway involved in lung development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development." [GOC:dph, GOC:mtg_lung]
synonym: "hedgehog signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in lung development" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development

[Term]
id: GO:0060507
name: epidermal growth factor receptor signaling pathway involved in lung development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development." [GOC:dph, GOC:mtg_lung]
synonym: "epidermal growth factor receptor signalling pathway involved in lung development" EXACT [GOC:mah]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development

[Term]
id: GO:0060508
name: lung basal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary basal cell differentiation" BROAD [GOC:dph, GOC:mtg_lung]
is_a: GO:0060479 ! lung cell differentiation
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060509
name: type I pneumocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles." [GOC:dph, GOC:mtg_lung, ISBN:0721662544]
synonym: "membranous pneumocyte differentiation" EXACT [GOC:dph, ISBN:0721662544]
synonym: "small alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544]
synonym: "squamous alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0060510
name: type II pneumocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies." [GOC:dph, GOC:mtg_lung, ISBN:0721662544]
synonym: "granular pneumocyte differentiation" RELATED [GOC:dph, ISBN:0721662544]
synonym: "great alveolar cell differentiation" EXACT [GOC:dph, ISBN:0721662544]
synonym: "large alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544]
is_a: GO:0061140 ! lung secretory cell differentiation

[Term]
id: GO:0060511
name: obsolete creation of an inductive signal by a mesenchymal cell involved in lung induction
namespace: biological_process
def: "OBSOLETE. The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud." [GOC:dph, GOC:mtg_lung]
comment: The reason for obsoletion is that the term is not clearly defined and there is no annotations.
is_obsolete: true

[Term]
id: GO:0060512
name: prostate gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a prostate gland are generated and organized." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060513
name: prostatic bud formation
namespace: biological_process
def: "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph, PMID:18977204]
synonym: "primary prostate bud formation" EXACT [GOC:dph]
synonym: "prostate ductal budding" EXACT [GOC:dph, PMID:11401393]
synonym: "prostate gland formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! animal organ formation
is_a: GO:0060572 ! morphogenesis of an epithelial bud
is_a: GO:0060601 ! lateral sprouting from an epithelium
is_a: GO:0060740 ! prostate gland epithelium morphogenesis

[Term]
id: GO:0060514
name: prostate induction
namespace: biological_process
def: "The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, PMID:18977204]
is_a: GO:0001759 ! organ induction
is_a: GO:0060685 ! regulation of prostatic bud formation
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0060515 ! prostate field specification

[Term]
id: GO:0060515
name: prostate field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010092 ! specification of animal organ identity
relationship: part_of GO:0060513 ! prostatic bud formation

[Term]
id: GO:0060516
name: primary prostatic bud elongation
namespace: biological_process
def: "The increase in size of the prostatic bud as it forms." [GOC:dph, PMID:18977204]
synonym: "prostate bud elongation" BROAD [GOC:dph]
synonym: "prostate bud elongation involved in prostate morphogenesis" EXACT [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
is_a: GO:0060737 ! prostate gland morphogenetic growth
is_a: GO:0060740 ! prostate gland epithelium morphogenesis

[Term]
id: GO:0060517
name: epithelial cell proliferation involved in prostatic bud elongation
namespace: biological_process
def: "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0060767 ! epithelial cell proliferation involved in prostate gland development
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060518
name: cell migration involved in prostatic bud elongation
namespace: biological_process
def: "The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060519
name: cell adhesion involved in prostatic bud elongation
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0007155 ! cell adhesion
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060520
name: obsolete activation of prostate induction by androgen receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, GOC:tb, PMID:18977204]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of prostate induction by androgen receptor signalling pathway" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030521
consider: GO:0060514

[Term]
id: GO:0060521
name: mesenchymal-epithelial cell signaling involved in prostate induction
namespace: biological_process
def: "Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate." [GOC:dph, PMID:18977204]
synonym: "mesenchymal-epithelial cell signalling involved in prostate induction" EXACT [GOC:mah]
is_a: GO:0060522 ! inductive mesenchymal to epithelial cell signaling
is_a: GO:0060739 ! mesenchymal-epithelial cell signaling involved in prostate gland development
relationship: part_of GO:0060514 ! prostate induction

[Term]
id: GO:0060522
name: inductive mesenchymal to epithelial cell signaling
namespace: biological_process
def: "Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells." [GOC:dph]
synonym: "inductive mesenchymal to epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0060523
name: prostate epithelial cord elongation
namespace: biological_process
def: "The developmental growth process in which solid chords of prostate epithelium increase in length." [GOC:dph, PMID:18977204]
is_a: GO:0060602 ! branch elongation of an epithelium
is_a: GO:0060737 ! prostate gland morphogenetic growth
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060524
name: dichotomous subdivision of prostate epithelial cord terminal unit
namespace: biological_process
def: "The process in which a prostate epithelial cord bifurcates at its end." [GOC:dph, PMID:18977204]
synonym: "prostate epithelial cord bifurcation" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060525
name: prostate glandular acinus development
namespace: biological_process
def: "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060526
name: prostate glandular acinus morphogenesis
namespace: biological_process
def: "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland." [GOC:dph]
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060527
name: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
namespace: biological_process
def: "The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini." [GOC:dph, PMID:18977204]
is_a: GO:0060442 ! branching involved in prostate gland morphogenesis
relationship: part_of GO:0060526 ! prostate glandular acinus morphogenesis

[Term]
id: GO:0060528
name: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate." [GOC:dph, PMID:18977204]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060529
name: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate." [GOC:dph, PMID:18977204]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0048863 ! stem cell differentiation
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060530
name: smooth muscle cell differentiation involved in prostate glandular acinus development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060531
name: neuroendocrine cell differentiation involved in prostate gland acinus development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus." [GOC:dph, PMID:18977204]
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060532
name: bronchus cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cartilage development" EXACT []
is_a: GO:0051216 ! cartilage development
relationship: part_of GO:0060433 ! bronchus development

[Term]
id: GO:0060533
name: bronchus cartilage morphogenesis
namespace: biological_process
def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0060434 ! bronchus morphogenesis
relationship: part_of GO:0060532 ! bronchus cartilage development

[Term]
id: GO:0060534
name: trachea cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051216 ! cartilage development
relationship: part_of GO:0060438 ! trachea development

[Term]
id: GO:0060535
name: trachea cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0060439 ! trachea morphogenesis
relationship: part_of GO:0060534 ! trachea cartilage development

[Term]
id: GO:0060536
name: cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0060537
name: muscle tissue development
namespace: biological_process
def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0060538
name: skeletal muscle organ development
namespace: biological_process
def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]
is_a: GO:0007517 ! muscle organ development

[Term]
id: GO:0060539
name: diaphragm development
namespace: biological_process
def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph]
is_a: GO:0060538 ! skeletal muscle organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060540
name: diaphragm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph]
is_a: GO:0048644 ! muscle organ morphogenesis
relationship: part_of GO:0060539 ! diaphragm development

[Term]
id: GO:0060541
name: respiratory system development
namespace: biological_process
def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]
subset: goslim_drosophila
is_a: GO:0048731 ! system development

[Term]
id: GO:0060542
name: regulation of strand invasion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:tb]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0042148 ! DNA strand invasion

[Term]
id: GO:0060543
name: negative regulation of strand invasion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:elh, GOC:tb]
synonym: "negative regulation of D-loop biosynthesis" RELATED [GOC:elh]
synonym: "negative regulation of D-loop formation" RELATED [GOC:elh]
synonym: "negative regulation of Rad51-mediated strand invasion" EXACT [GOC:elh]
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0060542 ! regulation of strand invasion
relationship: negatively_regulates GO:0042148 ! DNA strand invasion

[Term]
id: GO:0060544
name: regulation of necroptotic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of necroptosis" NARROW []
is_a: GO:0062098 ! regulation of programmed necrotic cell death
relationship: regulates GO:0070266 ! necroptotic process

[Term]
id: GO:0060545
name: positive regulation of necroptotic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of necroptosis" NARROW []
is_a: GO:0060544 ! regulation of necroptotic process
is_a: GO:0062100 ! positive regulation of programmed necrotic cell death
relationship: positively_regulates GO:0070266 ! necroptotic process

[Term]
id: GO:0060546
name: negative regulation of necroptotic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "negative regulation of necroptosis" NARROW []
is_a: GO:0060544 ! regulation of necroptotic process
is_a: GO:0062099 ! negative regulation of programmed necrotic cell death
relationship: negatively_regulates GO:0070266 ! necroptotic process

[Term]
id: GO:0060547
name: obsolete negative regulation of necrotic cell death
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was made obsolete because it represents a phenotype
is_obsolete: true

[Term]
id: GO:0060548
name: obsolete negative regulation of cell death
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represent an assay and not a GO process.
is_obsolete: true

[Term]
id: GO:0060549
name: regulation of fructose 1,6-bisphosphate 1-phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity

[Term]
id: GO:0060550
name: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0060549 ! regulation of fructose 1,6-bisphosphate 1-phosphatase activity

[Term]
id: GO:0060551
name: regulation of fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process

[Term]
id: GO:0060552
name: positive regulation of fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0060551 ! regulation of fructose 1,6-bisphosphate metabolic process
relationship: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process

[Term]
id: GO:0060556
name: regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0042368 ! vitamin D biosynthetic process

[Term]
id: GO:0060557
name: positive regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
relationship: positively_regulates GO:0042368 ! vitamin D biosynthetic process

[Term]
id: GO:0060558
name: regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0060559
name: positive regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity

[Term]
id: GO:0060560
name: developmental growth involved in morphogenesis
namespace: biological_process
def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]
synonym: "differential growth" EXACT [GOC:dph]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0060561
name: apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in development" RELATED []
synonym: "apoptosis involved in morphogenesis" NARROW []
synonym: "morphogenetic apoptosis" RELATED [GOC:dph]
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0060562
name: epithelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0035239 ! tube morphogenesis

[Term]
id: GO:0060563
name: neuroepithelial cell differentiation
namespace: biological_process
def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0060565
name: obsolete inhibition of APC-Cdc20 complex activity
namespace: biological_process
def: "OBSOLETE. Any process that prevents the activation of APC-Cdc20 complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it was not clearly defined and thus used incorrectly in annotation.
synonym: "inhibition of APC activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of APC-Cdc20 complex activity" EXACT []
synonym: "inhibition of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "inhibition of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "inhibition of mitotic anaphase-promoting complex activity" RELATED [GOC:vw]
is_obsolete: true
consider: GO:1990948

[Term]
id: GO:0060566
name: positive regulation of termination of DNA-templated transcription
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "positive regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "positive regulation of DNA-templated transcription, termination" EXACT []
synonym: "positive regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "positive regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0031554 ! regulation of termination of DNA-templated transcription
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
relationship: positively_regulates GO:0006353 ! DNA-templated transcription termination

[Term]
id: GO:0060567
name: negative regulation of termination of DNA-templated transcription
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "negative regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "negative regulation of DNA-templated transcription, termination" EXACT []
synonym: "negative regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "negative regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0031554 ! regulation of termination of DNA-templated transcription
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
relationship: negatively_regulates GO:0006353 ! DNA-templated transcription termination

[Term]
id: GO:0060568
name: regulation of peptide hormone processing
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0070613 ! regulation of protein processing
relationship: regulates GO:0016486 ! peptide hormone processing

[Term]
id: GO:0060569
name: positive regulation of peptide hormone processing
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0010954 ! positive regulation of protein processing
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0060568 ! regulation of peptide hormone processing
relationship: positively_regulates GO:0016486 ! peptide hormone processing

[Term]
id: GO:0060570
name: negative regulation of peptide hormone processing
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0060568 ! regulation of peptide hormone processing
relationship: negatively_regulates GO:0016486 ! peptide hormone processing

[Term]
id: GO:0060571
name: morphogenesis of an epithelial fold
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph]
synonym: "epithelial folding" EXACT [GOC:dph]
synonym: "folding of an epithelial sheet" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0060572
name: morphogenesis of an epithelial bud
namespace: biological_process
def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph]
is_a: GO:0060571 ! morphogenesis of an epithelial fold

[Term]
id: GO:0060573
name: cell fate specification involved in pattern specification
namespace: biological_process
def: "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification

[Term]
id: GO:0060574
name: intestinal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
relationship: part_of GO:0060576 ! intestinal epithelial cell development

[Term]
id: GO:0060575
name: intestinal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0060576
name: intestinal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation

[Term]
id: GO:0060577
name: pulmonary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph]
synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis

[Term]
id: GO:0060578
name: superior vena cava morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis

[Term]
id: GO:0060579
name: ventral spinal cord interneuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph]
is_a: GO:0048663 ! neuron fate commitment
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning
relationship: part_of GO:0021514 ! ventral spinal cord interneuron differentiation

[Term]
id: GO:0060580
name: ventral spinal cord interneuron fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph]
is_a: GO:0048664 ! neuron fate determination
is_a: GO:0060582 ! cell fate determination involved in pattern specification
relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment

[Term]
id: GO:0060581
name: cell fate commitment involved in pattern specification
namespace: biological_process
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0007389 ! pattern specification process

[Term]
id: GO:0060582
name: cell fate determination involved in pattern specification
namespace: biological_process
def: "A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification

[Term]
id: GO:0060583
name: regulation of actin cortical patch localization
namespace: biological_process
def: "Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:dph, GOC:tb]
synonym: "regulation of actin cortical patch localisation" EXACT [GOC:mah]
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0051666 ! actin cortical patch localization

[Term]
id: GO:0060584
name: regulation of prostaglandin-endoperoxide synthase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of (PG)H synthase activity" RELATED [EC:1.14.99.1]
synonym: "regulation of fatty acid cyclooxygenase activity" RELATED [EC:1.14.99.1]
synonym: "regulation of PG synthetase activity" RELATED [EC:1.14.99.1]
synonym: "regulation of prostaglandin synthetase activity" RELATED [EC:1.14.99.1]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0060585
name: positive regulation of prostaglandin-endoperoxide synthase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of (PG)H synthase activity" RELATED [EC:1.14.99.1]
synonym: "positive regulation of fatty acid cyclooxygenase activity" RELATED [EC:1.14.99.1]
synonym: "positive regulation of PG synthetase activity" RELATED [EC:1.14.99.1]
synonym: "positive regulation of prostaglandin synthetase activity" RELATED [EC:1.14.99.1]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:0060584 ! regulation of prostaglandin-endoperoxide synthase activity

[Term]
id: GO:0060586
name: multicellular organismal-level iron ion homeostasis
namespace: biological_process
def: "A chemical homeostatic process involved in the maintenance of a steady state level of iron within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [PMID:31431773]
synonym: "multicellular organismal iron ion homeostasis" EXACT []
is_a: GO:0055080 ! monoatomic cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis
is_a: GO:0140962 ! multicellular organismal-level chemical homeostasis

[Term]
id: GO:0060587
name: regulation of lipoprotein lipid oxidation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0034442 ! regulation of lipoprotein oxidation
relationship: regulates GO:0034439 ! lipoprotein lipid oxidation

[Term]
id: GO:0060588
name: negative regulation of lipoprotein lipid oxidation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0034443 ! negative regulation of lipoprotein oxidation
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0060587 ! regulation of lipoprotein lipid oxidation
relationship: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation

[Term]
id: GO:0060589
name: nucleoside-triphosphatase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of an NTPase." [GOC:dph, GOC:tb]
synonym: "NTPase regulator activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0060590
name: ATPase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]
synonym: "ATP hydrolysis regulator activity" EXACT []
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0060591
name: chondroblast differentiation
namespace: biological_process
def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph]
synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0060592
name: mammary gland formation
namespace: biological_process
def: "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme." [GOC:dph, PMID:16168142, PMID:17120154]
synonym: "mammary bud formation" RELATED [GOC:dph]
synonym: "mammary line formation" NARROW [GOC:dph]
synonym: "mammary placode formation" NARROW [GOC:dph]
synonym: "mammary sprout formation" RELATED [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060443 ! mammary gland morphogenesis

[Term]
id: GO:0060593
name: obsolete Wnt signaling pathway involved in mammary gland specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in mammary gland specification" EXACT []
synonym: "Wnt receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in mammary gland specification" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0016055
consider: GO:0030879

[Term]
id: GO:0060594
name: mammary gland specification
namespace: biological_process
def: "The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph]
synonym: "mammary line specification" RELATED [GOC:dph]
is_a: GO:0010092 ! specification of animal organ identity
is_a: GO:0060592 ! mammary gland formation

[Term]
id: GO:0060595
name: fibroblast growth factor receptor signaling pathway involved in mammary gland specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142]
synonym: "fibroblast growth factor receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0060594 ! mammary gland specification

[Term]
id: GO:0060596
name: mammary placode formation
namespace: biological_process
def: "The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper." [GOC:dph, PMID:16168142]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0060592 ! mammary gland formation

[Term]
id: GO:0060597
name: obsolete regulation of transcription from RNA polymerase II promoter involved in mammary gland formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of the mammary line, placode or bud." [GOC:dph, PMID:16168142]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0030879
consider: GO:0060592

[Term]
id: GO:0060598
name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which the terminal end of a mammary duct bifurcates." [GOC:dph, PMID:17120154]
synonym: "primary mammary duct branching" EXACT [GOC:dph]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching

[Term]
id: GO:0060599
name: lateral sprouting involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which a branch forms along the side of a mammary duct." [GOC:dph, PMID:17120154]
synonym: "mammary gland duct secondary branching" EXACT [GOC:dph]
is_a: GO:0060601 ! lateral sprouting from an epithelium
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060600
name: dichotomous subdivision of an epithelial terminal unit
namespace: biological_process
def: "The process in which an epithelial cord, rod or tube bifurcates at its end." [GOC:dph]
synonym: "primary branching of an epithelium" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium

[Term]
id: GO:0060601
name: lateral sprouting from an epithelium
namespace: biological_process
def: "The process in which a branch forms along the side of an epithelium." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium

[Term]
id: GO:0060602
name: branch elongation of an epithelium
namespace: biological_process
def: "The growth process in which a branch increases in length from its base to its tip." [GOC:dph]
is_a: GO:0003401 ! axis elongation
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium

[Term]
id: GO:0060603
name: mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk." [GOC:dph, PMID:17120154]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060443 ! mammary gland morphogenesis
relationship: part_of GO:0061180 ! mammary gland epithelium development

[Term]
id: GO:0060604
name: mammary gland duct cavitation
namespace: biological_process
def: "Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod." [GOC:dph, PMID:17120154]
synonym: "milk duct cavitation" RELATED [GOC:dph]
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060605
name: tube lumen cavitation
namespace: biological_process
def: "The formation of a lumen by hollowing out a solid rod or cord." [GOC:dph]
is_a: GO:0035148 ! tube formation

[Term]
id: GO:0060606
name: tube closure
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." [GOC:dph]
is_a: GO:0035148 ! tube formation

[Term]
id: GO:0060607
name: cell-cell adhesion involved in sealing an epithelial fold
namespace: biological_process
def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube." [GOC:dph]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0060606 ! tube closure

[Term]
id: GO:0060608
name: cell-cell adhesion involved in neural tube closure
namespace: biological_process
def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube." [GOC:dph]
is_a: GO:0060607 ! cell-cell adhesion involved in sealing an epithelial fold
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0060609
name: apoptotic process involved in tube lumen cavitation
namespace: biological_process
def: "Any apoptotic process that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in tube lumen cavitation" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
relationship: part_of GO:0060605 ! tube lumen cavitation

[Term]
id: GO:0060610
name: mesenchymal cell differentiation involved in mammary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts." [GOC:dph]
synonym: "mammary gland mesenchymal cell differentiation" EXACT [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060611
name: mammary gland fat development
namespace: biological_process
def: "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GOC:dph]
is_a: GO:0060612 ! adipose tissue development
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060612
name: adipose tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph]
synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0060613
name: fat pad development
namespace: biological_process
def: "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue." [GOC:dph]
is_a: GO:0060612 ! adipose tissue development

[Term]
id: GO:0060614
name: obsolete negative regulation of mammary gland development in males by androgen receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell." [GOC:dph]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model
synonym: "negative regulation of mammary gland development in males by androgen receptor signalling pathway" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030521

[Term]
id: GO:0060615
name: mammary gland bud formation
namespace: biological_process
def: "The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis." [GOC:dph, PMID:12558599]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060648 ! mammary gland bud morphogenesis

[Term]
id: GO:0060616
name: mammary gland cord formation
namespace: biological_process
def: "The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad." [GOC:dph, PMID:12558599]
synonym: "mammary gland sprout formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060617
name: positive regulation of mammary placode formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode." [GOC:dph, PMID:12558599]
synonym: "positive regulation of mammary placode formation by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: positively_regulates GO:0060596 ! mammary placode formation

[Term]
id: GO:0060618
name: nipple development
namespace: biological_process
def: "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060619
name: cell migration involved in mammary placode formation
namespace: biological_process
def: "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode." [GOC:dph, PMID:12558599]
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0060596 ! mammary placode formation

[Term]
id: GO:0060620
name: regulation of cholesterol import
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: regulates GO:0070508 ! cholesterol import

[Term]
id: GO:0060621
name: negative regulation of cholesterol import
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0060620 ! regulation of cholesterol import
relationship: negatively_regulates GO:0070508 ! cholesterol import

[Term]
id: GO:0060622
name: regulation of ascospore wall beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0090093 ! regulation of fungal-type cell wall beta-glucan biosynthetic process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process

[Term]
id: GO:0060623
name: regulation of chromosome condensation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
relationship: regulates GO:0030261 ! chromosome condensation

[Term]
id: GO:0060624
name: regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D--glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb]
synonym: "regulation of ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "regulation of ascospore wall 1,3-beta-glucan biosynthetic process" BROAD []
is_a: GO:0060622 ! regulation of ascospore wall beta-glucan biosynthetic process
is_a: GO:0090334 ! regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
relationship: regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0060625
name: regulation of protein deneddylation
namespace: biological_process
alt_id: GO:0060626
def: "Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:dph, GOC:tb]
synonym: "regulation of cullin deneddylation" NARROW []
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: regulates GO:0000338 ! protein deneddylation

[Term]
id: GO:0060627
name: regulation of vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0060628
name: regulation of ER to Golgi vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport

[Term]
id: GO:0060629
name: regulation of homologous chromosome segregation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:dph, GOC:tb]
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0060630
name: obsolete regulation of M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of M/G1 transition of the mitotic cell cycle, the progression from M phase to G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "regulation of M/G1 transition of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0060631
name: regulation of meiosis I
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb]
is_a: GO:0040020 ! regulation of meiotic nuclear division
relationship: regulates GO:0007127 ! meiosis I

[Term]
id: GO:0060632
name: regulation of microtubule-based movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
relationship: regulates GO:0007018 ! microtubule-based movement

[Term]
id: GO:0060633
name: negative regulation of transcription initiation by RNA polymerase II
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "negative regulation of transcription initiation from RNA polymerase II promoter" EXACT []
is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II
is_a: GO:0060260 ! regulation of transcription initiation by RNA polymerase II
is_a: GO:2000143 ! negative regulation of DNA-templated transcription initiation
relationship: negatively_regulates GO:0006367 ! transcription initiation at RNA polymerase II promoter

[Term]
id: GO:0060634
name: regulation of 4,6-pyruvylated galactose residue biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain." [GOC:dph, GOC:tb]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process

[Term]
id: GO:0060635
name: positive regulation of (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb]
synonym: "positive regulation of 1,3-beta-D-glucan biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
relationship: positively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0060636
name: negative regulation of (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb]
synonym: "negative regulation of 1,3-beta-D-glucan biosynthetic process" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
relationship: negatively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0060637
name: positive regulation of lactation by mesenchymal-epithelial cell signaling
namespace: biological_process
def: "The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell." [GOC:dph, PMID:12558599]
synonym: "positive regulation of lactation by mesenchymal-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:1903489 ! positive regulation of lactation

[Term]
id: GO:0060638
name: mesenchymal-epithelial cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph]
synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0060639
name: positive regulation of salivary gland formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell." [GOC:dph]
synonym: "positive regulation of salivary gland formation by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: positively_regulates GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060640
name: positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud." [GOC:dph]
synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling" RELATED []
synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0042488 ! positive regulation of odontogenesis of dentin-containing tooth
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling

[Term]
id: GO:0060641
name: mammary gland duct regression in males
namespace: biological_process
def: "The process in which the epithelium of the mammary duct is destroyed in males." [GOC:dph, PMID:12558599]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060642
name: white fat cell differentiation involved in mammary gland fat development
namespace: biological_process
def: "The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [GOC:dph, PMID:12558599]
is_a: GO:0050872 ! white fat cell differentiation
relationship: part_of GO:0060611 ! mammary gland fat development

[Term]
id: GO:0060643
name: epithelial cell differentiation involved in mammary gland bud morphogenesis
namespace: biological_process
def: "The process in which a cell of the mammary placode becomes a cell of the mammary gland bud." [GOC:dph]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
relationship: part_of GO:0060615 ! mammary gland bud formation

[Term]
id: GO:0060644
name: mammary gland epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0061180 ! mammary gland epithelium development

[Term]
id: GO:0060645
name: peripheral mammary gland bud epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically." [GOC:dph, PMID:12558599]
is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis

[Term]
id: GO:0060646
name: internal mammary gland bud epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape." [GOC:dph, PMID:12558599]
is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis

[Term]
id: GO:0060647
name: mesenchymal cell condensation involved in mammary fat development
namespace: biological_process
def: "The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development." [GOC:dph, PMID:12558599]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0060611 ! mammary gland fat development

[Term]
id: GO:0060648
name: mammary gland bud morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord." [GOC:dph, PMID:12558599]
is_a: GO:0060572 ! morphogenesis of an epithelial bud
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060649
name: mammary gland bud elongation
namespace: biological_process
def: "The process in which the mammary gland bud grows along its axis." [GOC:dph, PMID:12558599]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060648 ! mammary gland bud morphogenesis

[Term]
id: GO:0060650
name: epithelial cell proliferation involved in mammary gland bud elongation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud." [GOC:dph, PMID:12558599]
is_a: GO:0033598 ! mammary gland epithelial cell proliferation
relationship: part_of GO:0060649 ! mammary gland bud elongation

[Term]
id: GO:0060651
name: regulation of epithelial cell proliferation involved in mammary gland bud elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud." [GOC:dph, PMID:12558599]
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation

[Term]
id: GO:0060652
name: mammary gland cord morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat." [GOC:dph, PMID:12558599]
synonym: "mammary gland sprout morphogenesis" EXACT [GOC:dph]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060653
name: epithelial cell differentiation involved in mammary gland cord morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified." [GOC:dph, PMID:12558599]
synonym: "epithelial cell differentiation involved in mammary gland sprout morphogenesis" RELATED [GOC:dph]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060654
name: mammary gland cord elongation
namespace: biological_process
def: "The process in which the mammary gland sprout grows along its axis." [GOC:dph, PMID:12558599]
is_a: GO:0060751 ! branch elongation involved in mammary gland duct branching
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060655
name: branching involved in mammary gland cord morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct." [GOC:dph, PMID:12558599]
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060656
name: regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell." [GOC:dph, PMID:12558599]
synonym: "regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis
relationship: regulates GO:0060655 ! branching involved in mammary gland cord morphogenesis

[Term]
id: GO:0060657
name: regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell." [GOC:dph, PMID:12558599]
synonym: "regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0060654 ! mammary gland cord elongation

[Term]
id: GO:0060658
name: nipple morphogenesis
namespace: biological_process
def: "The process in which the nipple is generated and organized." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060443 ! mammary gland morphogenesis
relationship: part_of GO:0060618 ! nipple development

[Term]
id: GO:0060659
name: nipple sheath formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate." [GOC:dph, PMID:12558599]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060658 ! nipple morphogenesis

[Term]
id: GO:0060660
name: epidermis morphogenesis involved in nipple formation
namespace: biological_process
def: "The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection." [GOC:dph, PMID:12558599]
is_a: GO:0048730 ! epidermis morphogenesis
relationship: part_of GO:0060658 ! nipple morphogenesis

[Term]
id: GO:0060661
name: submandibular salivary gland formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed." [GOC:dph, PMID:17336109]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060662
name: salivary gland cavitation
namespace: biological_process
def: "The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland." [GOC:dph]
synonym: "salivary gland invagination" EXACT []
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060663
name: apoptotic process involved in salivary gland cavitation
namespace: biological_process
def: "Any apoptotic process in which the solid core of the gland is hollowed out to form the duct." [GOC:dph, GOC:mtg_apoptosis, PMID:17336109]
synonym: "apoptosis involved in salivary gland cavitation" NARROW []
is_a: GO:0060609 ! apoptotic process involved in tube lumen cavitation
relationship: part_of GO:0060662 ! salivary gland cavitation

[Term]
id: GO:0060664
name: epithelial cell proliferation involved in salivary gland morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland." [GOC:dph, PMID:17336109]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060665
name: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium." [GOC:dph, PMID:17336109]
synonym: "regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis

[Term]
id: GO:0060666
name: dichotomous subdivision of terminal units involved in salivary gland branching
namespace: biological_process
def: "The process in which a salivary epithelial cord bifurcates at its end." [GOC:dph]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis

[Term]
id: GO:0060667
name: branch elongation involved in salivary gland morphogenesis
namespace: biological_process
def: "The differential growth of the salivary branches along their axis, resulting in the growth of a branch." [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis

[Term]
id: GO:0060668
name: regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland." [GOC:dph]
synonym: "regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0035426 ! extracellular matrix-cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis

[Term]
id: GO:0060669
name: embryonic placenta morphogenesis
namespace: biological_process
def: "The process in which the embryonic placenta is generated and organized." [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060670
name: branching involved in labyrinthine layer morphogenesis
namespace: biological_process
def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis

[Term]
id: GO:0060671
name: epithelial cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060672
name: epithelial cell morphogenesis involved in placental branching
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377]
is_a: GO:0003382 ! epithelial cell morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060670 ! branching involved in labyrinthine layer morphogenesis
relationship: part_of GO:0060671 ! epithelial cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060673
name: cell-cell signaling involved in placenta development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377]
synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060674
name: placenta blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377]
is_a: GO:0001568 ! blood vessel development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0060675
name: ureteric bud morphogenesis
namespace: biological_process
def: "The process in which the ureteric bud is generated and organized." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
relationship: part_of GO:0001657 ! ureteric bud development

[Term]
id: GO:0060676
name: ureteric bud formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378]
is_a: GO:0072172 ! mesonephric tubule formation
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0060677
name: ureteric bud elongation
namespace: biological_process
def: "The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated." [GOC:dph, PMID:16916378]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0060678
name: dichotomous subdivision of terminal units involved in ureteric bud branching
namespace: biological_process
def: "The process in which a ureteric bud bifurcates at its end." [GOC:dph, PMID:16916378]
synonym: "bifid subdivision of terminal units involved in ureteric bud branching" EXACT [GOC:dph, PMID:16916378]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0060679
name: trifid subdivision of terminal units involved in ureteric bud branching
namespace: biological_process
def: "The process in which a ureteric bud splits into three units at its end." [GOC:dph, PMID:16916378]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0060680
name: lateral sprouting involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process in which a branch forms along the side of a ureteric bud." [GOC:dph, PMID:16916378]
is_a: GO:0060601 ! lateral sprouting from an epithelium
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0060681
name: branch elongation involved in ureteric bud branching
namespace: biological_process
def: "The growth of a branch of the ureteric bud along its axis." [GOC:dph, PMID:16916378]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: part_of GO:0060677 ! ureteric bud elongation

[Term]
id: GO:0060682
name: primary ureteric bud growth
namespace: biological_process
def: "The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema." [GOC:dph, PMID:16916378]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060677 ! ureteric bud elongation

[Term]
id: GO:0060683
name: regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland." [GOC:dph, PMID:18559345]
synonym: "regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling" EXACT [GOC:mah]
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis

[Term]
id: GO:0060684
name: epithelial-mesenchymal cell signaling
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0060685
name: regulation of prostatic bud formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph]
is_a: GO:0003156 ! regulation of animal organ formation
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0060513 ! prostatic bud formation

[Term]
id: GO:0060686
name: negative regulation of prostatic bud formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph]
is_a: GO:0060685 ! regulation of prostatic bud formation
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0060513 ! prostatic bud formation

[Term]
id: GO:0060687
name: regulation of branching involved in prostate gland morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060688
name: regulation of morphogenesis of a branching structure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001763 ! morphogenesis of a branching structure

[Term]
id: GO:0060689
name: cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0060690
name: epithelial cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development

[Term]
id: GO:0060691
name: epithelial cell maturation involved in salivary gland development
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0060690 ! epithelial cell differentiation involved in salivary gland development

[Term]
id: GO:0060692
name: mesenchymal cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development

[Term]
id: GO:0060693
name: regulation of branching involved in salivary gland morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0060445 ! branching involved in salivary gland morphogenesis

[Term]
id: GO:0060694
name: regulation of cholesterol transporter activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0110112 ! regulation of lipid transporter activity

[Term]
id: GO:0060695
name: negative regulation of cholesterol transporter activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0060694 ! regulation of cholesterol transporter activity
is_a: GO:0110114 ! negative regulation of lipid transporter activity

[Term]
id: GO:0060696
name: regulation of phospholipid catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: regulates GO:0009395 ! phospholipid catabolic process

[Term]
id: GO:0060697
name: positive regulation of phospholipid catabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0060696 ! regulation of phospholipid catabolic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
relationship: positively_regulates GO:0009395 ! phospholipid catabolic process

[Term]
id: GO:0060698
name: endoribonuclease inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of endoribonuclease." [GOC:dph, GOC:tb]
is_a: GO:0008428 ! ribonuclease inhibitor activity

[Term]
id: GO:0060699
name: regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0060700 ! regulation of ribonuclease activity

[Term]
id: GO:0060700
name: regulation of ribonuclease activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0051252 ! regulation of RNA metabolic process

[Term]
id: GO:0060701
name: negative regulation of ribonuclease activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0032074 ! negative regulation of nuclease activity
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:0060700 ! regulation of ribonuclease activity

[Term]
id: GO:0060702
name: negative regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0060699 ! regulation of endoribonuclease activity
is_a: GO:0060701 ! negative regulation of ribonuclease activity

[Term]
id: GO:0060703
name: deoxyribonuclease inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of deoxyribonuclease." [GOC:dph, GOC:tb]
synonym: "DNase inhibitor activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0140721 ! nuclease inhibitor activity

[Term]
id: GO:0060704
name: acinar cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland." [GOC:dph, GOC:tb]
is_a: GO:0060690 ! epithelial cell differentiation involved in salivary gland development
is_a: GO:0090425 ! acinar cell differentiation

[Term]
id: GO:0060705
name: neuron differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland." [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development

[Term]
id: GO:0060706
name: cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060707
name: trophoblast giant cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua." [GOC:dph, PMID:16269175]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060708
name: spongiotrophoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell." [GOC:dph, PMID:16269175]
synonym: "spongiotrophoblast cell differentiation" EXACT [GOC:cjm]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060712 ! spongiotrophoblast layer development

[Term]
id: GO:0060709
name: glycogen cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer." [GOC:dph, PMID:16269175]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060712 ! spongiotrophoblast layer development

[Term]
id: GO:0060710
name: chorio-allantoic fusion
namespace: biological_process
def: "The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois." [GOC:dph]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis

[Term]
id: GO:0060711
name: labyrinthine layer development
namespace: biological_process
def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060712
name: spongiotrophoblast layer development
namespace: biological_process
def: "The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state." [GOC:dph]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060713
name: labyrinthine layer morphogenesis
namespace: biological_process
def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060669 ! embryonic placenta morphogenesis
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060714
name: labyrinthine layer formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis

[Term]
id: GO:0060715
name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development
namespace: biological_process
def: "The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta." [GOC:dph]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060716
name: labyrinthine layer blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
is_a: GO:0060674 ! placenta blood vessel development
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060717
name: chorion development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph]
is_a: GO:1903867 ! extraembryonic membrane development

[Term]
id: GO:0060718
name: chorionic trophoblast cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [CL:0011101, GOC:dph, PMID:16983341]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060717 ! chorion development

[Term]
id: GO:0060719
name: chorionic trophoblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0011101, GOC:16983341, GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation

[Term]
id: GO:0060720
name: spongiotrophoblast cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer." [GOC:dph]
is_a: GO:0060722 ! cell proliferation involved in embryonic placenta development
relationship: part_of GO:0090214 ! spongiotrophoblast layer developmental growth

[Term]
id: GO:0060721
name: regulation of spongiotrophoblast cell proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation." [GOC:dph]
is_a: GO:0060723 ! regulation of cell proliferation involved in embryonic placenta development
relationship: regulates GO:0060720 ! spongiotrophoblast cell proliferation

[Term]
id: GO:0060722
name: cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060723
name: regulation of cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development

[Term]
id: GO:0060724
name: obsolete coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: molecular_function
def: "OBSOLETE. Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway." [GOC:dph, GOC:tb]
comment: Precomposed term that should be captured as GO-CAMs or extension.
synonym: "coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0060725
name: regulation of coreceptor activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0010469 ! regulation of signaling receptor activity

[Term]
id: GO:0060726
name: obsolete regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0060727
name: obsolete positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0060728
name: obsolete negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0060729
name: intestinal epithelial structure maintenance
namespace: biological_process
def: "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "epithelial structure maintenance of intestine" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of intestinal epithelium" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030277 ! maintenance of gastrointestinal epithelium

[Term]
id: GO:0060730
name: regulation of intestinal epithelial structure maintenance
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0060729 ! intestinal epithelial structure maintenance

[Term]
id: GO:0060731
name: positive regulation of intestinal epithelial structure maintenance
namespace: biological_process
def: "Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:dph, GOC:tb]
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0060730 ! regulation of intestinal epithelial structure maintenance
relationship: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance

[Term]
id: GO:0060732
name: positive regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb]
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0060734
name: regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress" EXACT []
synonym: "regulation of eIF2 alpha phosphorylation by ER stress" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress
relationship: regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress

[Term]
id: GO:0060735
name: regulation of eIF2 alpha phosphorylation by dsRNA
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of eIF2 alpha phosphorylation by double-stranded RNA" EXACT [GOC:dph]
synonym: "regulation of eIF2 alpha phosphorylation by PKR" NARROW [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: part_of GO:0071359 ! cellular response to dsRNA
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation

[Term]
id: GO:0060736
name: prostate gland growth
namespace: biological_process
def: "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060737
name: prostate gland morphogenetic growth
namespace: biological_process
def: "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form." [GOC:dph]
synonym: "prostate gland growth involved in morphogenesis" EXACT [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
is_a: GO:0060736 ! prostate gland growth
relationship: part_of GO:0060512 ! prostate gland morphogenesis

[Term]
id: GO:0060738
name: epithelial-mesenchymal signaling involved in prostate gland development
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time." [GOC:dph]
synonym: "epithelial-mesenchymal signalling involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060739
name: mesenchymal-epithelial cell signaling involved in prostate gland development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time." [GOC:dph]
synonym: "mesenchymal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060740
name: prostate gland epithelium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0060512 ! prostate gland morphogenesis

[Term]
id: GO:0060741
name: prostate gland stromal morphogenesis
namespace: biological_process
def: "The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060512 ! prostate gland morphogenesis
relationship: part_of GO:0061448 ! connective tissue development

[Term]
id: GO:0060742
name: epithelial cell differentiation involved in prostate gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060743
name: epithelial cell maturation involved in prostate gland development
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
synonym: "prostate gland epithelial cell development" EXACT [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0060742 ! epithelial cell differentiation involved in prostate gland development

[Term]
id: GO:0060744
name: mammary gland branching involved in thelarche
namespace: biological_process
def: "The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, PMID:19261859]
synonym: "mammary gland branching involved in puberty" RELATED [GOC:dph]
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0042695 ! thelarche

[Term]
id: GO:0060745
name: mammary gland branching involved in pregnancy
namespace: biological_process
def: "The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy." [GOC:dph, PMID:19261859]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0060135 ! maternal process involved in female pregnancy
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060746
name: parental behavior
namespace: biological_process
def: "A reproductive behavior in which a parent cares for and rears offspring." [GOC:dph]
is_a: GO:0019098 ! reproductive behavior

[Term]
id: GO:0060747
name: oral incubation
namespace: biological_process
def: "A parental behavior in which fertilized eggs are taken into the mouth and held until hatching." [GOC:dph]
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0060748
name: tertiary branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy." [GOC:dph, PMID:18614704]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0060745 ! mammary gland branching involved in pregnancy

[Term]
id: GO:0060749
name: mammary gland alveolus development
namespace: biological_process
def: "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061377 ! mammary gland lobule development

[Term]
id: GO:0060750
name: epithelial cell proliferation involved in mammary gland duct elongation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth." [GOC:dph]
is_a: GO:0033598 ! mammary gland epithelial cell proliferation
relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching

[Term]
id: GO:0060751
name: branch elongation involved in mammary gland duct branching
namespace: biological_process
def: "The developmental growth process in which a branch of a mammary gland duct elongates." [GOC:dph]
synonym: "mammary gland duct branch elongation" EXACT [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060752
name: intestinal phytosterol absorption
namespace: biological_process
def: "A process in which phytosterols are taken up from the contents of the intestine." [GOC:dph, GOC:tb]
is_a: GO:0098856 ! intestinal lipid absorption

[Term]
id: GO:0060753
name: regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0002551 ! mast cell chemotaxis

[Term]
id: GO:0060754
name: positive regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0060753 ! regulation of mast cell chemotaxis
relationship: positively_regulates GO:0002551 ! mast cell chemotaxis

[Term]
id: GO:0060755
name: negative regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0060753 ! regulation of mast cell chemotaxis
relationship: negatively_regulates GO:0002551 ! mast cell chemotaxis

[Term]
id: GO:0060756
name: foraging behavior
namespace: biological_process
def: "Behavior by which an organism locates food." [GOC:dph, GOC:tb]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0060757
name: adult foraging behavior
namespace: biological_process
def: "Behavior by which an adult locates food." [GOC:dph, GOC:tb]
is_a: GO:0060756 ! foraging behavior

[Term]
id: GO:0060758
name: foraging behavior by probing substrate
namespace: biological_process
def: "Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food." [GOC:dph, GOC:tb]
is_a: GO:0060756 ! foraging behavior

[Term]
id: GO:0060759
name: regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0034097 ! response to cytokine

[Term]
id: GO:0060760
name: positive regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: positively_regulates GO:0034097 ! response to cytokine

[Term]
id: GO:0060761
name: negative regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: negatively_regulates GO:0034097 ! response to cytokine

[Term]
id: GO:0060762
name: regulation of branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060763
name: mammary duct terminal end bud growth
namespace: biological_process
def: "The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty." [GOC:dph, PMID:10804170]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060764
name: cell-cell signaling involved in mammary gland development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." [GOC:dph]
synonym: "cell-cell signalling involved in mammary gland development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060765
name: regulation of androgen receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph]
synonym: "regulation of androgen receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
relationship: regulates GO:0030521 ! androgen receptor signaling pathway

[Term]
id: GO:0060766
name: negative regulation of androgen receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph]
synonym: "negative regulation of androgen receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0060765 ! regulation of androgen receptor signaling pathway
relationship: negatively_regulates GO:0030521 ! androgen receptor signaling pathway

[Term]
id: GO:0060767
name: epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060768
name: regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development

[Term]
id: GO:0060769
name: positive regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development

[Term]
id: GO:0060770
name: negative regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development

[Term]
id: GO:0060771
name: phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of plant organs (leaves or leaf-like structures) or flower primordia around a central axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009956 ! radial pattern formation

[Term]
id: GO:0060772
name: leaf phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060771 ! phyllotactic patterning

[Term]
id: GO:0060773
name: flower phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060771 ! phyllotactic patterning

[Term]
id: GO:0060774
name: obsolete auxin mediated signaling pathway involved in phyllotactic patterning
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "auxin mediated signalling pathway involved in phyllotactic patterning" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0009734
consider: GO:0060771

[Term]
id: GO:0060775
name: obsolete planar cell polarity pathway involved in gastrula mediolateral intercalation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0060776
name: simple leaf morphogenesis
namespace: biological_process
def: "The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0060777
name: compound leaf morphogenesis
namespace: biological_process
def: "The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0060778
name: primary leaflet morphogenesis
namespace: biological_process
def: "The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0060779
name: secondary leaflet morphogenesis
namespace: biological_process
def: "The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0060780
name: intercalary leaflet morphogenesis
namespace: biological_process
def: "The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0060781
name: mesenchymal cell proliferation involved in prostate gland development
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph, PMID:12221011]
is_a: GO:0010463 ! mesenchymal cell proliferation
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060782
name: regulation of mesenchymal cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, PMID:12221011]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development

[Term]
id: GO:0060783
name: mesenchymal smoothened signaling pathway involved in prostate gland development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development." [PMID:12221011]
synonym: "mesenchymal hedgehog signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd]
synonym: "mesenchymal hh signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd]
synonym: "mesenchymal smoothened signalling pathway involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0060738 ! epithelial-mesenchymal signaling involved in prostate gland development

[Term]
id: GO:0060784
name: regulation of cell proliferation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0060785
name: regulation of apoptosis involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph]
is_a: GO:0042981 ! regulation of apoptotic process
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0060786
name: regulation of cell differentiation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0060787
name: positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "positive regulation of posterior neural plate formation by FGF receptor signaling pathway" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: positively_regulates GO:0090018 ! posterior neural plate formation

[Term]
id: GO:0060788
name: ectodermal placode formation
namespace: biological_process
def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0071697 ! ectodermal placode morphogenesis

[Term]
id: GO:0060789
name: hair follicle placode formation
namespace: biological_process
def: "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0001942 ! hair follicle development

[Term]
id: GO:0060790
name: tooth placode formation
namespace: biological_process
def: "The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0060791
name: sebaceous gland placode formation
namespace: biological_process
def: "The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0048733 ! sebaceous gland development

[Term]
id: GO:0060792
name: sweat gland development
namespace: biological_process
def: "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0060793
name: sweat gland placode formation
namespace: biological_process
def: "The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0060792 ! sweat gland development

[Term]
id: GO:0060794
name: leaflet morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the leaflet are generated and organized." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060777 ! compound leaf morphogenesis

[Term]
id: GO:0060795
name: cell fate commitment involved in formation of primary germ layer
namespace: biological_process
def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001704 ! formation of primary germ layer

[Term]
id: GO:0060796
name: obsolete regulation of transcription involved in primary germ layer cell fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0060795

[Term]
id: GO:0060797
name: obsolete transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0060798
name: obsolete transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0060799
name: obsolete transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0060800
name: regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060801
name: obsolete negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway
namespace: biological_process
def: "OBSOLETE. The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0060802
name: epiblast cell-extraembryonic ectoderm cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell." [GOC:dph, GOC:tb, PMID:14511481, PMID:31391456]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0060803
name: obsolete BMP signaling pathway involved in mesodermal cell fate specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007501
consider: GO:0030509

[Term]
id: GO:0060804
name: obsolete positive regulation of Wnt signaling pathway by BMP signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of WNT receptor signaling pathway by BMP signaling pathway" EXACT [GOC:bf]
synonym: "positive regulation of WNT receptor signalling pathway by BMP signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of Wnt-activated signaling pathway by BMP signaling pathway" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0030111
consider: GO:0030509

[Term]
id: GO:0060805
name: obsolete negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0060806
name: negative regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060807
name: obsolete regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0001714
consider: GO:0006357

[Term]
id: GO:0060808
name: positive regulation of mesodermal to mesenchymal transition involved in gastrulation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation

[Term]
id: GO:0060809
name: mesodermal to mesenchymal transition involved in gastrulation
namespace: biological_process
def: "The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0060810
name: intracellular mRNA localization involved in pattern specification process
namespace: biological_process
def: "Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "intracellular mRNA localisation involved in pattern specification process" EXACT [GOC:mah]
is_a: GO:0008298 ! intracellular mRNA localization
relationship: part_of GO:0007389 ! pattern specification process

[Term]
id: GO:0060811
name: intracellular mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "intracellular mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah]
is_a: GO:0060810 ! intracellular mRNA localization involved in pattern specification process
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0060812
name: orthodenticle mRNA localization
namespace: biological_process
def: "Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "orthodenticle mRNA localisation" EXACT [GOC:mah]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification

[Term]
id: GO:0060813
name: anterior mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "anterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification

[Term]
id: GO:0060814
name: posterior mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "posterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification

[Term]
id: GO:0060815
name: regulation of translation involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006417 ! regulation of translation
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0060816
name: random inactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb, PMID:32189388]
synonym: "rXCI" RELATED []
is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome

[Term]
id: GO:0060817
name: obsolete inactivation of paternal X chromosome
namespace: biological_process
def: "OBSOLETE. Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because its was equivalent to 'inactivation of paternal X chromosome by genomic imprinting ; GO:0060818.
is_obsolete: true
replaced_by: GO:0060818

[Term]
id: GO:0060818
name: inactivation of paternal X chromosome by genomic imprinting
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genomic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb, PMID:11743158, PMID:16789828, PMID:18425126, PMID:23578369]
comment: Imprinting controlled inactivation of the paternal X chromosome appears to be the ancestral form of sex chromosome inactivation in therian mammals. In eutherian mammals, imprinted X inactivation (iXCI) has largely been replaced by random X inactivation in a process regulated by the Xist and additional ncRNA's encoded within the "choice" region of the X chromosome. In a few mammals with early zygotic genome activation, imprinted X inactivation of the paternal X chromsome occurs very early during embryonic development. Imprinted iXCI has been observed in mice, rats, and bovines, and is best studied in mice where it occurs in the 4 cell stage in mice. In epiblast cells which will become the embryo proper, the inactivated paternal X chromosome is reactivated and dosage compensation of the X chromosome is regenerated by random X inactivation in embryonic tissues. In extraembryonic tissues, the selective inactivation of the paternal chromosome remains and is essential for proper development of the placenta. Selective inactivation of the paternal X chromosome via imprinting is the only form of X chromosome inactivation in marsupials, though the mechanism there may be significantly different in marsupials as the Xist transcript is not present on metatherian X chromosomes.
synonym: "inactivation of paternal X chromosome by genetic imprinting" RELATED []
synonym: "iXCI" RELATED []
is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome
is_a: GO:0071514 ! genomic imprinting

[Term]
id: GO:0060819
name: obsolete inactivation of X chromosome by genomic imprinting
namespace: biological_process
def: "OBSOLETE. Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because its was equivalent to 'inactivation of paternal X chromosome by genomic imprinting ; GO:0060818.
synonym: "inactivation of X chromosome by genetic imprinting" RELATED []
is_obsolete: true
replaced_by: GO:0060818

[Term]
id: GO:0060820
name: obsolete inactivation of X chromosome by heterochromatin formation
namespace: biological_process
def: "OBSOLETE. Compensating for the two-fold variation in X-chromosome: autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because its meaning was ambiguous and the term was used inconsistently.
synonym: "inactivation of X chromosome by heterochromatin assembly" EXACT []
is_obsolete: true
consider: GO:0060816
consider: GO:0060818

[Term]
id: GO:0060821
name: obsolete inactivation of X chromosome by DNA methylation
namespace: biological_process
def: "OBSOLETE. Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0009048
consider: GO:0035514

[Term]
id: GO:0060822
name: obsolete transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transforming growth factor beta receptor signalling pathway involved in axial mesodermal cell fate specification" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0060823
name: obsolete canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal]
is_obsolete: true
consider: GO:0060070

[Term]
id: GO:0060824
name: obsolete retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model.
synonym: "retinoic acid receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0048384
consider: GO:0090017

[Term]
id: GO:0060825
name: fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0060826
name: obsolete transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transforming growth factor beta receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0060827
name: obsolete regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of Wnt signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling]
synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal]
is_obsolete: true

[Term]
id: GO:0060828
name: regulation of canonical Wnt signaling pathway
namespace: biological_process
alt_id: GO:0035411
alt_id: GO:0035412
def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "catenin import into nucleus" NARROW []
synonym: "regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "regulation of catenin import into nucleus" NARROW []
synonym: "regulation of catenin protein nuclear translocation" NARROW [GOC:mah]
synonym: "regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
relationship: regulates GO:0060070 ! canonical Wnt signaling pathway

[Term]
id: GO:0060829
name: obsolete negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern" EXACT [GOC:signaling]
synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal]
is_obsolete: true

[Term]
id: GO:0060830
name: ciliary receptor clustering involved in smoothened signaling pathway
namespace: biological_process
def: "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway." [GOC:cilia, GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "ciliary receptor clustering involved in hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "ciliary receptor clustering involved in hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "ciliary receptor clustering involved in smoothened signalling pathway" EXACT [GOC:mah]
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0060831
name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0021904 ! dorsal/ventral neural tube patterning

[Term]
id: GO:0060832
name: oocyte animal/vegetal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007309 ! oocyte axis specification

[Term]
id: GO:0060833
name: obsolete Wnt signaling pathway involved in animal/vegetal axis specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in animal/vegetal axis specification" EXACT []
synonym: "Wnt receptor signalling pathway involved in animal/vegetal axis specification" EXACT [GOC:mah]
synonym: "Wnt- activated signaling pathway involved in animal/vegetal axis specification" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0016055
consider: GO:0060832

[Term]
id: GO:0060834
name: oral/aboral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "oral/aboral axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification

[Term]
id: GO:0060835
name: obsolete transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transforming growth factor receptor beta signalling pathway involved in oral/aboral axis specification" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0060836
name: lymphatic endothelial cell differentiation
namespace: biological_process
def: "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
relationship: part_of GO:0001945 ! lymph vessel development

[Term]
id: GO:0060837
name: blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0060838
name: lymphatic endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060839 ! endothelial cell fate commitment
relationship: part_of GO:0060836 ! lymphatic endothelial cell differentiation

[Term]
id: GO:0060839
name: endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0060840
name: artery development
namespace: biological_process
def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development

[Term]
id: GO:0060841
name: venous blood vessel development
namespace: biological_process
def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development

[Term]
id: GO:0060842
name: arterial endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060843
name: venous endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060844
name: arterial endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060846 ! blood vessel endothelial cell fate commitment
relationship: part_of GO:0060842 ! arterial endothelial cell differentiation

[Term]
id: GO:0060845
name: venous endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060846 ! blood vessel endothelial cell fate commitment
relationship: part_of GO:0060843 ! venous endothelial cell differentiation

[Term]
id: GO:0060846
name: blood vessel endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060839 ! endothelial cell fate commitment
relationship: part_of GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060847
name: endothelial cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060839 ! endothelial cell fate commitment

[Term]
id: GO:0060848
name: endothelial cell fate determination
namespace: biological_process
def: "A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060839 ! endothelial cell fate commitment

[Term]
id: GO:0060849
name: obsolete regulation of transcription involved in lymphatic endothelial cell fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0060838

[Term]
id: GO:0060850
name: obsolete regulation of transcription involved in cell fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0045165

[Term]
id: GO:0060851
name: vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "vascular endothelial growth factor receptor signalling pathway involved in lymphatic endothelial cell fate commitment" EXACT [GOC:mah]
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment

[Term]
id: GO:0060852
name: obsolete regulation of transcription involved in venous endothelial cell fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate and contributes to a cell adopting a venous endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0060845

[Term]
id: GO:0060853
name: Notch signaling pathway involved in arterial endothelial cell fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "Notch signalling pathway involved in arterial endothelial cell fate commitment" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0060844 ! arterial endothelial cell fate commitment

[Term]
id: GO:0060854
name: branching involved in lymph vessel morphogenesis
namespace: biological_process
def: "The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "patterning of lymph vessels" BROAD [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
relationship: part_of GO:0001946 ! lymphangiogenesis

[Term]
id: GO:0060855
name: venous endothelial cell migration involved in lymph vessel development
namespace: biological_process
def: "The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0001945 ! lymph vessel development

[Term]
id: GO:0060856
name: establishment of blood-brain barrier
namespace: biological_process
def: "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:aruk, GOC:dph, GOC:sart, PMID:20080302, PMID:30280653]
synonym: "establishment of BBB" EXACT []
synonym: "establishment of blood/brain barrier" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0060857
name: establishment of glial blood-brain barrier
namespace: biological_process
def: "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart, PMID:20080302]
synonym: "establishment of glial BBB" EXACT []
synonym: "establishment of glial blood/brain barrier" EXACT []
is_a: GO:0021782 ! glial cell development
is_a: GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0060858
name: obsolete vesicle-mediated transport involved in floral organ abscission
namespace: biological_process
def: "OBSOLETE. The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "membrane trafficking involved in floral organ shedding" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb]
is_obsolete: true
consider: GO:0010227
consider: GO:0016192

[Term]
id: GO:0060859
name: obsolete regulation of vesicle-mediated transport involved in floral organ abscission
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of the directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it does not represent a specific pathway.
is_obsolete: true

[Term]
id: GO:0060860
name: regulation of floral organ abscission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0010227 ! floral organ abscission

[Term]
id: GO:0060861
name: positive regulation of floral organ abscission
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060860 ! regulation of floral organ abscission
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0010227 ! floral organ abscission

[Term]
id: GO:0060862
name: negative regulation of floral organ abscission
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060860 ! regulation of floral organ abscission
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0010227 ! floral organ abscission

[Term]
id: GO:0060863
name: regulation of floral organ abscission by signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007165 ! signal transduction
is_a: GO:0060860 ! regulation of floral organ abscission

[Term]
id: GO:0060864
name: obsolete positive regulation of floral organ abscission by small GTPase mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that increases the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it does not represent a specific pathway.
is_obsolete: true

[Term]
id: GO:0060865
name: obsolete negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007178

[Term]
id: GO:0060866
name: leaf abscission
namespace: biological_process
def: "The controlled shedding of a leaf." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009838 ! abscission

[Term]
id: GO:0060867
name: fruit abscission
namespace: biological_process
def: "The controlled shedding of a fruit." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009838 ! abscission

[Term]
id: GO:0060868
name: obsolete regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it does not represent a specific pathway.
is_obsolete: true

[Term]
id: GO:0060869
name: obsolete transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:signaling, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway involved in floral organ abscission" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007178

[Term]
id: GO:0060870
name: cell wall disassembly involved in floral organ abscission
namespace: biological_process
def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009830 ! cell wall modification involved in abscission
relationship: part_of GO:0010227 ! floral organ abscission

[Term]
id: GO:0060872
name: semicircular canal development
namespace: biological_process
def: "The progression of the semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0060873
name: anterior semicircular canal development
namespace: biological_process
def: "The progession of the anterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development

[Term]
id: GO:0060874
name: posterior semicircular canal development
namespace: biological_process
def: "The progession of the posterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development

[Term]
id: GO:0060875
name: lateral semicircular canal development
namespace: biological_process
def: "The progession of the lateral semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development

[Term]
id: GO:0060876
name: semicircular canal formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0035148 ! tube formation
relationship: part_of GO:0048752 ! semicircular canal morphogenesis

[Term]
id: GO:0060877
name: regionalization involved in semicircular canal formation
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0060876 ! semicircular canal formation

[Term]
id: GO:0060878
name: pouch outgrowth involved in semicircular canal formation
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0060876 ! semicircular canal formation

[Term]
id: GO:0060879
name: semicircular canal fusion
namespace: biological_process
def: "Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms during the process of semicircular canal formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0060876 ! semicircular canal formation

[Term]
id: GO:0060880
name: cell morphogenesis involved in semicircular canal fusion
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060879 ! semicircular canal fusion

[Term]
id: GO:0060882
name: basement membrane disassembly involved in semicircular canal fusion
namespace: biological_process
def: "A process that results in the breakdown of the basement membrane that contributes to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "basal lamina disassembly involved in semicircular canal fusion" RELATED []
is_a: GO:0034769 ! basement membrane disassembly
relationship: part_of GO:0060879 ! semicircular canal fusion

[Term]
id: GO:0060883
name: obsolete regulation of basement membrane disassembly involved in semicircular canal fusion by cell communication
namespace: biological_process
def: "OBSOLETE. Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basement membrane disassembly involved in semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication" RELATED []
is_obsolete: true

[Term]
id: GO:0060884
name: clearance of cells from fusion plate
namespace: biological_process
def: "The morphogenetic process in which cells are removed from the inner loop of a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048752 ! semicircular canal morphogenesis

[Term]
id: GO:0060885
name: clearance of cells from fusion plate by apoptotic process
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals." [GOC:dph, GOC:mtg_apoptosis, GOC:sdb_2009, GOC:tb]
synonym: "clearance of cells from fusion plate by apoptosis" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
is_a: GO:0060884 ! clearance of cells from fusion plate

[Term]
id: GO:0060886
name: clearance of cells from fusion plate by epithelial to mesenchymal transition
namespace: biological_process
def: "The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0060884 ! clearance of cells from fusion plate

[Term]
id: GO:0060887
name: limb epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0098773 ! skin epidermis development
relationship: part_of GO:0060173 ! limb development

[Term]
id: GO:0060888
name: limb epidermis stratification
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0060887 ! limb epidermis development

[Term]
id: GO:0060889
name: limb basal epidermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009913 ! epidermal cell differentiation
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0060887 ! limb epidermis development

[Term]
id: GO:0060890
name: limb spinous cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030216 ! keratinocyte differentiation
relationship: part_of GO:0060887 ! limb epidermis development

[Term]
id: GO:0060891
name: limb granular cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030216 ! keratinocyte differentiation
relationship: part_of GO:0060887 ! limb epidermis development

[Term]
id: GO:0060892
name: limb basal epidermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060889 ! limb basal epidermal cell differentiation

[Term]
id: GO:0060893
name: limb granular cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060891 ! limb granular cell differentiation

[Term]
id: GO:0060894
name: limb spinous cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060890 ! limb spinous cell differentiation

[Term]
id: GO:0060895
name: obsolete retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it is a pre-composed term that represents a GO-CAM model.
synonym: "retinoic acid receptor signalling pathway involved in spinal cord dorsal/ventral patterning" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0021513
consider: GO:0048384

[Term]
id: GO:0060896
name: neural plate pattern specification
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0060897
name: neural plate regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0060896 ! neural plate pattern specification

[Term]
id: GO:0060898
name: eye field cell fate commitment involved in camera-type eye formation
namespace: biological_process
def: "The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
relationship: part_of GO:0046619 ! lens placode formation involved in camera-type eye formation
relationship: part_of GO:0060897 ! neural plate regionalization

[Term]
id: GO:0060899
name: obsolete regulation of transcription involved in eye field cell fate commitment of camera-type eye
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neurectodermal cell to a specialized neurectodermal cell that will give rise to the optic vesicle." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0060898

[Term]
id: GO:0060900
name: embryonic camera-type eye formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis

[Term]
id: GO:0060901
name: obsolete regulation of hair cycle by canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of hair cycle by canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of hair cycle by canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of hair cycle by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_obsolete: true
consider: GO:0042634
consider: GO:0060070

[Term]
id: GO:0060902
name: obsolete regulation of hair cycle by BMP signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of hair cycle by BMP signalling pathway" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030509
consider: GO:0042634

[Term]
id: GO:0060903
name: positive regulation of meiosis I
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb]
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:0060631 ! regulation of meiosis I
relationship: positively_regulates GO:0007127 ! meiosis I

[Term]
id: GO:0060904
name: regulation of protein folding in endoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:dph, GOC:tb]
is_a: GO:1903332 ! regulation of protein folding
relationship: regulates GO:0034975 ! protein folding in endoplasmic reticulum

[Term]
id: GO:0060905
name: regulation of induction of conjugation upon nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation

[Term]
id: GO:0060906
name: negative regulation of regulatory ncRNA-mediated heterochromatin formation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of non-coding RNA-mediated heterochromatin formation." [GOC:dph, GOC:tb]
synonym: "negative regulation of chromatin silencing by small RNA" RELATED []
synonym: "negative regulation of heterochromatin assembly by small RNA" NARROW []
synonym: "negative regulation of ncRNA-mediated heterochromatin formation" EXACT []
synonym: "negative regulation of RNAi-mediated heterochromatin assembly" EXACT []
synonym: "negative regulation of small non-coding RNA-mediated heterochromatin formation" NARROW []
is_a: GO:0010964 ! regulation of regulatory ncRNA-mediated heterochromatin formation
is_a: GO:0031452 ! negative regulation of heterochromatin formation
is_a: GO:0060967 ! negative regulation of gene silencing by regulatory ncRNA
relationship: negatively_regulates GO:0031048 ! regulatory ncRNA-mediated heterochromatin formation

[Term]
id: GO:0060907
name: positive regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb]
is_a: GO:0010935 ! regulation of macrophage cytokine production
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
relationship: positively_regulates GO:0010934 ! macrophage cytokine production

[Term]
id: GO:0060908
name: plasmid copy number maintenance
namespace: biological_process
def: "The maintenance of the number of copies of extrachromosomal plasmid DNA." [GOC:dph, GOC:tb]
is_a: GO:0006276 ! plasmid maintenance

[Term]
id: GO:0060909
name: regulation of DNA replication initiation involved in plasmid copy number maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb]
is_a: GO:0030174 ! regulation of DNA-templated DNA replication initiation
relationship: part_of GO:0060908 ! plasmid copy number maintenance

[Term]
id: GO:0060910
name: negative regulation of DNA replication initiation involved in plasmid copy number maintenance
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb]
is_a: GO:0032297 ! negative regulation of DNA-templated DNA replication initiation
is_a: GO:0060909 ! regulation of DNA replication initiation involved in plasmid copy number maintenance

[Term]
id: GO:0060911
name: cardiac cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system." [GOC:mtg_heart]
synonym: "cardiocyte cell fate commitment" EXACT [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:0060912
name: cardiac cell fate specification
namespace: biological_process
def: "The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:mtg_heart]
synonym: "cardiocyte cell fate specification" EXACT [GOC:dph]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060911 ! cardiac cell fate commitment

[Term]
id: GO:0060913
name: cardiac cell fate determination
namespace: biological_process
def: "The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:mtg_heart]
synonym: "cardiocyte cell fate determination" RELATED [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060911 ! cardiac cell fate commitment

[Term]
id: GO:0060914
name: heart formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "cardiogenesis" RELATED [GOC:mtg_heart]
is_a: GO:0048645 ! animal organ formation
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0060915
name: mesenchymal cell differentiation involved in lung development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060916
name: mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph]
is_a: GO:0010463 ! mesenchymal cell proliferation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060917
name: regulation of (1->6)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:dph, GOC:tb]
synonym: "regulation of 1,6-beta-glucan biosynthetic process" EXACT []
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
relationship: regulates GO:0006078 ! (1->6)-beta-D-glucan biosynthetic process

[Term]
id: GO:0060918
name: auxin transport
namespace: biological_process
def: "The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Auxins are a group of plant hormones that regulates aspects of plant growth." [GOC:dph, GOC:tb]
is_a: GO:0009914 ! hormone transport

[Term]
id: GO:0060919
name: auxin import into cell
namespace: biological_process
def: "The directed movement of auxins from outside of a cell into a cell." [PMID:22773749]
synonym: "auxin influx" BROAD []
is_a: GO:0060918 ! auxin transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0060920
name: cardiac pacemaker cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell differentiation" BROAD []
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0060921
name: sinoatrial node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart]
synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
relationship: part_of GO:0003163 ! sinoatrial node development

[Term]
id: GO:0060922
name: atrioventricular node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart]
synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart]
is_a: GO:0003292 ! cardiac septum cell differentiation
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
relationship: part_of GO:0003162 ! atrioventricular node development

[Term]
id: GO:0060923
name: cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart]
synonym: "heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0042693 ! muscle cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0060924
name: atrial cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "atrial cardiomyocyte cell fate commitment" RELATED [GOC:mtg_heart]
synonym: "atrial heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation

[Term]
id: GO:0060925
name: ventricular cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "ventricular cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart]
synonym: "ventricular heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation

[Term]
id: GO:0060926
name: cardiac pacemaker cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell development" BROAD []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation

[Term]
id: GO:0060927
name: cardiac pacemaker cell fate commitment
namespace: biological_process
def: "The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell fate commitment" BROAD []
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation

[Term]
id: GO:0060928
name: atrioventricular node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "AV node cell development" EXACT [GOC:mtg_heart]
is_a: GO:0060926 ! cardiac pacemaker cell development
relationship: part_of GO:0060922 ! atrioventricular node cell differentiation

[Term]
id: GO:0060929
name: atrioventricular node cell fate commitment
namespace: biological_process
def: "The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells." [GOC:mtg_heart]
synonym: "AV node cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060927 ! cardiac pacemaker cell fate commitment
relationship: part_of GO:0060922 ! atrioventricular node cell differentiation

[Term]
id: GO:0060930
name: sinoatrial node cell fate commitment
namespace: biological_process
def: "The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell commitment" EXACT [GOC:mtg_heart]
synonym: "SAN cell commitment" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell commitment" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060927 ! cardiac pacemaker cell fate commitment
relationship: part_of GO:0060921 ! sinoatrial node cell differentiation

[Term]
id: GO:0060931
name: sinoatrial node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell development" EXACT [GOC:mtg_heart]
synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060926 ! cardiac pacemaker cell development
relationship: part_of GO:0060921 ! sinoatrial node cell differentiation

[Term]
id: GO:0060932
name: His-Purkinje system cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055007 ! cardiac muscle cell differentiation
relationship: part_of GO:0003164 ! His-Purkinje system development

[Term]
id: GO:0060933
name: His-Purkinje system cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation

[Term]
id: GO:0060934
name: His-Purkinje system cell fate commitment
namespace: biological_process
def: "The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation

[Term]
id: GO:0060935
name: cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:0060936
name: cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060937
name: cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060938
name: epicardium-derived cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060939
name: epicardium-derived cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060936 ! cardiac fibroblast cell development
relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060940
name: epithelial to mesenchymal transition involved in cardiac fibroblast development
namespace: biological_process
def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development

[Term]
id: GO:0060941
name: epicardium-derived cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060937 ! cardiac fibroblast cell fate commitment
relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060942
name: neural crest-derived cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060943
name: neural crest-derived cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060936 ! cardiac fibroblast cell development
relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060944
name: neural crest-derived cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060937 ! cardiac fibroblast cell fate commitment
relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060945
name: cardiac neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0060946
name: cardiac blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
is_a: GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060947
name: cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation
relationship: part_of GO:0060976 ! coronary vasculature development

[Term]
id: GO:0060948
name: cardiac vascular smooth muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
is_a: GO:0097084 ! vascular associated smooth muscle cell development
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060949
name: cardiac vascular smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
is_a: GO:0097081 ! vascular associated smooth muscle cell fate commitment
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060950
name: cardiac glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:0060951
name: neural crest-derived cardiac glial cell differentiation
namespace: biological_process
def: "The process in which a neural crest cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0060950 ! cardiac glial cell differentiation

[Term]
id: GO:0060952
name: cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart]
is_a: GO:0021782 ! glial cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060950 ! cardiac glial cell differentiation

[Term]
id: GO:0060953
name: cardiac glial cell fate commitment
namespace: biological_process
def: "The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart]
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060950 ! cardiac glial cell differentiation

[Term]
id: GO:0060954
name: neural crest-derived cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:mtg_heart]
is_a: GO:0060952 ! cardiac glial cell development
relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation

[Term]
id: GO:0060955
name: neural crest-derived cardiac glial cell fate commitment
namespace: biological_process
def: "The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart]
is_a: GO:0060953 ! cardiac glial cell fate commitment
relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation

[Term]
id: GO:0060956
name: endocardial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
relationship: part_of GO:0003157 ! endocardium development

[Term]
id: GO:0060957
name: endocardial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0060839 ! endothelial cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060956 ! endocardial cell differentiation

[Term]
id: GO:0060958
name: endocardial cell development
namespace: biological_process
def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0001885 ! endothelial cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060956 ! endocardial cell differentiation

[Term]
id: GO:0060959
name: cardiac neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart neuron development" EXACT [GOC:mtg_heart]
is_a: GO:0048666 ! neuron development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060945 ! cardiac neuron differentiation

[Term]
id: GO:0060960
name: cardiac neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0048663 ! neuron fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060945 ! cardiac neuron differentiation

[Term]
id: GO:0060961
name: phospholipase D inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of phospholipase D." [GOC:dph, GOC:tb]
is_a: GO:0004859 ! phospholipase inhibitor activity

[Term]
id: GO:0060962
name: regulation of ribosomal protein gene transcription by RNA polymerase II
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II

[Term]
id: GO:0060963
name: positive regulation of ribosomal protein gene transcription by RNA polymerase II
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II
is_a: GO:0060962 ! regulation of ribosomal protein gene transcription by RNA polymerase II

[Term]
id: GO:0060964
name: regulation of miRNA-mediated gene silencing
namespace: biological_process
def: "A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs)." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604]
synonym: "regulation of gene silencing by microRNA" EXACT [GOC:pr]
synonym: "regulation of gene silencing by miRNA" EXACT []
is_a: GO:1900368 ! regulation of post-transcriptional gene silencing by regulatory ncRNA
relationship: regulates GO:0035195 ! miRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0060965
name: negative regulation of miRNA-mediated gene silencing
namespace: biological_process
def: "A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA)." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604]
synonym: "negative regulation of gene silencing by microRNA" EXACT [GOC:bf, GOC:pr]
synonym: "negative regulation of gene silencing by miRNA" EXACT []
is_a: GO:0060964 ! regulation of miRNA-mediated gene silencing
is_a: GO:1900369 ! negative regulation of post-transcriptional gene silencing by regulatory ncRNA
relationship: negatively_regulates GO:0035195 ! miRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0060966
name: regulation of gene silencing by regulatory ncRNA
namespace: biological_process
def: "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
synonym: "regulation of gene silencing by RNA" RELATED []
is_a: GO:0010468 ! regulation of gene expression
relationship: regulates GO:0031047 ! regulatory ncRNA-mediated gene silencing

[Term]
id: GO:0060967
name: negative regulation of gene silencing by regulatory ncRNA
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
synonym: "negative regulation of gene silencing by ncRNA" RELATED []
synonym: "negative regulation of gene silencing by RNA" RELATED []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0060966 ! regulation of gene silencing by regulatory ncRNA
relationship: negatively_regulates GO:0031047 ! regulatory ncRNA-mediated gene silencing

[Term]
id: GO:0060968
name: obsolete regulation of gene silencing
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it was too broadly defined and could not be distinguished from 'GO:0040029 regulation of gene expression, epigenetic'.
is_obsolete: true
consider: GO:0040029

[Term]
id: GO:0060969
name: obsolete negative regulation of gene silencing
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
comment: This term was obsoleted because its definition was too broad.
is_obsolete: true
consider: GO:0010629
consider: GO:0031047
consider: GO:0031507

[Term]
id: GO:0060970
name: embryonic heart tube dorsal/ventral pattern formation
namespace: biological_process
def: "The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis." [GOC:mtg_heart]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0060971
name: embryonic heart tube left/right pattern formation
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:mtg_heart]
is_a: GO:0060972 ! left/right pattern formation
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0060972
name: left/right pattern formation
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:mtg_heart]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0060973
name: cell migration involved in heart development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060974
name: cell migration involved in heart formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0060914 ! heart formation

[Term]
id: GO:0060975
name: cardioblast migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "cardiac progenitor cell midline migration" EXACT [GOC:mtg_heart]
synonym: "cardioblast midline convergence" EXACT [GOC:mtg_heart]
is_a: GO:0003260 ! cardioblast migration
is_a: GO:0003318 ! cell migration to the midline involved in heart development
relationship: part_of GO:0060029 ! convergent extension involved in organogenesis

[Term]
id: GO:0060976
name: coronary vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart vasculature development" EXACT [GOC:mtg_heart]
is_a: GO:0001568 ! blood vessel development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060977
name: coronary vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart]
synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060976 ! coronary vasculature development

[Term]
id: GO:0060978
name: angiogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart]
synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001525 ! angiogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0060979
name: vasculogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart]
synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart]
synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001570 ! vasculogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0060980
name: cell migration involved in coronary vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart]
is_a: GO:0035441 ! cell migration involved in vasculogenesis
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis

[Term]
id: GO:0060981
name: cell migration involved in coronary angiogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis

[Term]
id: GO:0060982
name: coronary artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle." [GOC:mtg_heart]
is_a: GO:0048844 ! artery morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0060983
name: epicardium-derived cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart]
is_a: GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060984
name: epicardium-derived cardiac vascular smooth muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state." [GOC:mtg_heart]
is_a: GO:0060948 ! cardiac vascular smooth muscle cell development
relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060985
name: epicardium-derived cardiac vascular smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart]
is_a: GO:0060949 ! cardiac vascular smooth muscle cell fate commitment
relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060986
name: endocrine hormone secretion
namespace: biological_process
def: "The regulated release of a hormone into the circulatory system." [GOC:dph]
is_a: GO:0046879 ! hormone secretion
relationship: part_of GO:0050886 ! endocrine process

[Term]
id: GO:0060987
name: lipid tube
namespace: cellular_component
def: "A macromolecular complex that contains a tube of lipid surrounded by a protein coat." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032994 ! protein-lipid complex

[Term]
id: GO:0060988
name: lipid tube assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0065005 ! protein-lipid complex assembly

[Term]
id: GO:0060989
name: lipid tube assembly involved in organelle fusion
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation involved in organelle fusion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060988 ! lipid tube assembly
relationship: part_of GO:0048284 ! organelle fusion

[Term]
id: GO:0060990
name: lipid tube assembly involved in organelle fission
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation involved in organelle fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060988 ! lipid tube assembly
relationship: part_of GO:0048285 ! organelle fission

[Term]
id: GO:0060991
name: obsolete lipid tube assembly involved in cytokinesis
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in cytokinesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was made obsolete because there is no evidence the process exists.
synonym: "lipid tube assembly involved in cytokinesis" EXACT []
synonym: "lipid tubulation involved in cytokinesis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0060992
name: response to fungicide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi." [GOC:dph]
is_a: GO:0009636 ! response to toxic substance
is_a: GO:0046677 ! response to antibiotic

[Term]
id: GO:0060993
name: kidney morphogenesis
namespace: biological_process
def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0060994
name: obsolete regulation of transcription from RNA polymerase II promoter involved in kidney development
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state." [GOC:dph, GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0060995
name: cell-cell signaling involved in kidney development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in kidney development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0060996
name: dendritic spine development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0016358 ! dendrite development

[Term]
id: GO:0060997
name: dendritic spine morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0031175 ! neuron projection development
is_a: GO:0048812 ! neuron projection morphogenesis
is_a: GO:0097061 ! dendritic spine organization
relationship: part_of GO:0048813 ! dendrite morphogenesis
relationship: part_of GO:0060996 ! dendritic spine development

[Term]
id: GO:0060998
name: regulation of dendritic spine development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0060996 ! dendritic spine development

[Term]
id: GO:0060999
name: positive regulation of dendritic spine development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060998 ! regulation of dendritic spine development
relationship: positively_regulates GO:0060996 ! dendritic spine development

[Term]
id: GO:0061000
name: negative regulation of dendritic spine development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060998 ! regulation of dendritic spine development
relationship: negatively_regulates GO:0060996 ! dendritic spine development

[Term]
id: GO:0061001
name: regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0099175 ! regulation of postsynapse organization
relationship: regulates GO:0060997 ! dendritic spine morphogenesis

[Term]
id: GO:0061002
name: negative regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0061000 ! negative regulation of dendritic spine development
is_a: GO:0061001 ! regulation of dendritic spine morphogenesis
relationship: negatively_regulates GO:0060997 ! dendritic spine morphogenesis

[Term]
id: GO:0061003
name: positive regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0050775 ! positive regulation of dendrite morphogenesis
is_a: GO:0060999 ! positive regulation of dendritic spine development
is_a: GO:0061001 ! regulation of dendritic spine morphogenesis
relationship: positively_regulates GO:0060997 ! dendritic spine morphogenesis

[Term]
id: GO:0061004
name: pattern specification involved in kidney development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0001822 ! kidney development
relationship: part_of GO:0072048 ! renal system pattern specification

[Term]
id: GO:0061005
name: cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0061006
name: regulation of cell proliferation involved in kidney morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: part_of GO:0060993 ! kidney morphogenesis

[Term]
id: GO:0061007
name: hepaticobiliary system process
namespace: biological_process
def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
subset: goslim_generic
synonym: "hepatobiliary system process" EXACT [GOC:dph]
is_a: GO:0003008 ! system process

[Term]
id: GO:0061008
name: hepaticobiliary system development
namespace: biological_process
def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
synonym: "hepatobiliary system development" EXACT [GOC:dph]
is_a: GO:0048731 ! system development

[Term]
id: GO:0061009
name: common bile duct development
namespace: biological_process
def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine." [PMID:20614624]
synonym: "bile duct development" EXACT [GOC:dph]
synonym: "CBD development" EXACT [PMID:20614624]
synonym: "EHBD development" BROAD [PMID:20614624]
synonym: "extrahepatic bile duct development" BROAD [PMID:20614624]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0061010
name: gallbladder development
namespace: biological_process
def: "The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile." [GOC:dph]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0061011
name: hepatic duct development
namespace: biological_process
def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624]
is_a: GO:0061009 ! common bile duct development

[Term]
id: GO:0061013
name: regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903311 ! regulation of mRNA metabolic process
relationship: regulates GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0061014
name: positive regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "positive regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0061013 ! regulation of mRNA catabolic process
is_a: GO:1903313 ! positive regulation of mRNA metabolic process
relationship: positively_regulates GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0061015
name: snRNA import into nucleus
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006404 ! RNA import into nucleus
is_a: GO:0051030 ! snRNA transport

[Term]
id: GO:0061016
name: snRNA localization to Cajal body
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid, to a Cajal body." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090670 ! RNA localization to Cajal body

[Term]
id: GO:0061017
name: hepatoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0061024
name: membrane organization
namespace: biological_process
alt_id: GO:0016044
alt_id: GO:0044802
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular membrane organisation" EXACT []
synonym: "cellular membrane organization" EXACT []
synonym: "membrane organisation" EXACT [GOC:mah]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
synonym: "single-organism membrane organization" RELATED []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0061025
name: membrane fusion
namespace: biological_process
alt_id: GO:0006944
alt_id: GO:0044801
def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "cellular membrane fusion" EXACT []
synonym: "single-organism membrane fusion" RELATED []
xref: Wikipedia:Lipid_bilayer_fusion
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0061026
name: cardiac muscle tissue regeneration
namespace: biological_process
def: "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph]
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0061027
name: umbilical cord development
namespace: biological_process
def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0061028
name: establishment of endothelial barrier
namespace: biological_process
def: "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:dph]
is_a: GO:0001885 ! endothelial cell development

[Term]
id: GO:0061029
name: eyelid development in camera-type eye
namespace: biological_process
def: "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0061030
name: epithelial cell differentiation involved in mammary gland alveolus development
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus." [GOC:dph, GOC:yaf]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
relationship: part_of GO:0060749 ! mammary gland alveolus development

[Term]
id: GO:0061031
name: endodermal digestive tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm." [GOC:dph, GOC:yaf]
is_a: GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0061032
name: visceral serous pericardium development
namespace: biological_process
def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf]
synonym: "epicardium development" EXACT [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060039 ! pericardium development

[Term]
id: GO:0061033
name: secretion by lung epithelial cell involved in lung growth
namespace: biological_process
def: "The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development." [GOC:dph]
synonym: "fetal lung liquid secretion" RELATED [GOC:dph]
is_a: GO:0032940 ! secretion by cell
relationship: part_of GO:0060437 ! lung growth

[Term]
id: GO:0061034
name: olfactory bulb mitral cell layer development
namespace: biological_process
def: "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0061035
name: regulation of cartilage development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0051216 ! cartilage development

[Term]
id: GO:0061036
name: positive regulation of cartilage development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
relationship: positively_regulates GO:0051216 ! cartilage development

[Term]
id: GO:0061037
name: negative regulation of cartilage development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
relationship: negatively_regulates GO:0051216 ! cartilage development

[Term]
id: GO:0061038
name: uterus morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0060065 ! uterus development

[Term]
id: GO:0061040
name: female gonad morphogenesis
namespace: biological_process
def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph]
synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035262 ! gonad morphogenesis
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0061041
name: regulation of wound healing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph]
is_a: GO:1903034 ! regulation of response to wounding
relationship: regulates GO:0042060 ! wound healing

[Term]
id: GO:0061042
name: vascular wound healing
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph]
is_a: GO:0060055 ! angiogenesis involved in wound healing

[Term]
id: GO:0061043
name: regulation of vascular wound healing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:dph]
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0061041 ! regulation of wound healing
relationship: regulates GO:0061042 ! vascular wound healing

[Term]
id: GO:0061044
name: negative regulation of vascular wound healing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:0061043 ! regulation of vascular wound healing
is_a: GO:0061045 ! negative regulation of wound healing
relationship: negatively_regulates GO:0061042 ! vascular wound healing

[Term]
id: GO:0061045
name: negative regulation of wound healing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph]
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0061041 ! regulation of wound healing
is_a: GO:1903035 ! negative regulation of response to wounding
relationship: negatively_regulates GO:0042060 ! wound healing

[Term]
id: GO:0061046
name: regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0061047
name: positive regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0061048
name: negative regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0061049
name: cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph]
synonym: "cardiomyocyte growth" RELATED [GOC:dph]
synonym: "heart muscle cell growth" RELATED [GOC:dph]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy
relationship: part_of GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0061050
name: regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
relationship: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development

[Term]
id: GO:0061051
name: positive regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
relationship: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development

[Term]
id: GO:0061052
name: negative regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
relationship: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development

[Term]
id: GO:0061053
name: somite development
namespace: biological_process
def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0061054
name: dermatome development
namespace: biological_process
def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061053 ! somite development

[Term]
id: GO:0061055
name: myotome development
namespace: biological_process
def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061053 ! somite development

[Term]
id: GO:0061056
name: sclerotome development
namespace: biological_process
def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0061053 ! somite development

[Term]
id: GO:0061057
name: peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280, PMID:24706930]
synonym: "Imd signaling pathway" EXACT [GOC:dph]
synonym: "Imd signalling pathway" EXACT [GOC:dph]
synonym: "immune deficiency pathway" RELATED [GOC:dph]
synonym: "immune deficiency signaling pathway" RELATED [GOC:dph]
synonym: "PGRP signaling pathway" RELATED [GOC:dph]
is_a: GO:0002221 ! pattern recognition receptor signaling pathway
relationship: part_of GO:0042742 ! defense response to bacterium

[Term]
id: GO:0061058
name: regulation of peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]
synonym: "regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway

[Term]
id: GO:0061059
name: positive regulation of peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]
synonym: "positive regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1900426 ! positive regulation of defense response to bacterium
relationship: positively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway

[Term]
id: GO:0061060
name: negative regulation of peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]
synonym: "negative regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway
is_a: GO:1900425 ! negative regulation of defense response to bacterium
relationship: negatively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway

[Term]
id: GO:0061061
name: muscle structure development
namespace: biological_process
def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]
subset: goslim_drosophila
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0061062
name: regulation of nematode larval development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0002119 ! nematode larval development

[Term]
id: GO:0061063
name: positive regulation of nematode larval development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0061062 ! regulation of nematode larval development
relationship: positively_regulates GO:0002119 ! nematode larval development

[Term]
id: GO:0061064
name: negative regulation of nematode larval development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0061062 ! regulation of nematode larval development
relationship: negatively_regulates GO:0002119 ! nematode larval development

[Term]
id: GO:0061065
name: regulation of dauer larval development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv]
is_a: GO:0061062 ! regulation of nematode larval development
relationship: regulates GO:0040024 ! dauer larval development

[Term]
id: GO:0061066
name: positive regulation of dauer larval development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv]
is_a: GO:0061063 ! positive regulation of nematode larval development
is_a: GO:0061065 ! regulation of dauer larval development
relationship: positively_regulates GO:0040024 ! dauer larval development

[Term]
id: GO:0061067
name: negative regulation of dauer larval development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv]
is_a: GO:0061064 ! negative regulation of nematode larval development
is_a: GO:0061065 ! regulation of dauer larval development
relationship: negatively_regulates GO:0040024 ! dauer larval development

[Term]
id: GO:0061068
name: urethra development
namespace: biological_process
def: "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body." [GOC:dph]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0061069
name: male urethra development
namespace: biological_process
def: "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body." [GOC:dph]
is_a: GO:0061068 ! urethra development

[Term]
id: GO:0061070
name: female urethra development
namespace: biological_process
def: "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening." [GOC:dph]
is_a: GO:0061068 ! urethra development

[Term]
id: GO:0061071
name: urethra epithelium development
namespace: biological_process
def: "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes." [GOC:dph]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0061068 ! urethra development

[Term]
id: GO:0061072
name: iris morphogenesis
namespace: biological_process
def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0061073
name: ciliary body morphogenesis
namespace: biological_process
def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0061074
name: regulation of neural retina development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0003407 ! neural retina development

[Term]
id: GO:0061075
name: positive regulation of neural retina development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902868 ! positive regulation of retina development in camera-type eye
relationship: positively_regulates GO:0003407 ! neural retina development

[Term]
id: GO:0061076
name: negative regulation of neural retina development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902867 ! negative regulation of retina development in camera-type eye
relationship: negatively_regulates GO:0003407 ! neural retina development

[Term]
id: GO:0061077
name: chaperone-mediated protein folding
namespace: biological_process
def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0061078
name: positive regulation of prostaglandin secretion involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response." [GOC:BHF, GOC:dph]
synonym: "positive regulation of prostaglandin secretion during immune response" RELATED [GOC:dph]
is_a: GO:0032308 ! positive regulation of prostaglandin secretion
relationship: positively_regulates GO:0090323 ! prostaglandin secretion involved in immune response

[Term]
id: GO:0061079
name: left horn of sinus venosus development
namespace: biological_process
def: "The progression of the left horn of the sinus venosus from its initial formation to the mature structure." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003235 ! sinus venosus development

[Term]
id: GO:0061080
name: right horn of sinus venosus development
namespace: biological_process
def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003235 ! sinus venosus development

[Term]
id: GO:0061081
name: positive regulation of myeloid leukocyte cytokine production involved in immune response
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph]
synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph]
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
relationship: positively_regulates GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0061082
name: myeloid leukocyte cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0061083
name: regulation of protein refolding
namespace: biological_process
def: "Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:dph, GOC:tb]
is_a: GO:1903332 ! regulation of protein folding
relationship: regulates GO:0042026 ! protein refolding

[Term]
id: GO:0061084
name: negative regulation of protein refolding
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0061083 ! regulation of protein refolding
is_a: GO:1903333 ! negative regulation of protein folding
relationship: negatively_regulates GO:0042026 ! protein refolding

[Term]
id: GO:0061085
name: obsolete regulation of histone H3-K27 methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061086
name: obsolete negative regulation of histone H3-K27 methylation
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061087
name: obsolete positive regulation of histone H3-K27 methylation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061088
name: obsolete regulation of sequestering of zinc ion
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
comment: The reason for oboletion is that regulation of sequestering of X should be a molecular function.
is_obsolete: true

[Term]
id: GO:0061089
name: obsolete negative regulation of sequestering of zinc ion
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
comment: The reason for oboletion is that regulation of sequestering of X should be a molecular function.
is_obsolete: true

[Term]
id: GO:0061090
name: obsolete positive regulation of sequestering of zinc ion
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
comment: The reason for oboletion is that regulation of sequestering of X should be a molecular function.
is_obsolete: true

[Term]
id: GO:0061091
name: regulation of phospholipid translocation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0097035 ! regulation of membrane lipid distribution
is_a: GO:2001138 ! regulation of phospholipid transport
relationship: regulates GO:0045332 ! phospholipid translocation

[Term]
id: GO:0061092
name: positive regulation of phospholipid translocation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0061091 ! regulation of phospholipid translocation
is_a: GO:2001140 ! positive regulation of phospholipid transport
relationship: positively_regulates GO:0045332 ! phospholipid translocation

[Term]
id: GO:0061093
name: negative regulation of phospholipid translocation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0061091 ! regulation of phospholipid translocation
is_a: GO:2001139 ! negative regulation of phospholipid transport
relationship: negatively_regulates GO:0045332 ! phospholipid translocation

[Term]
id: GO:0061094
name: regulation of turning behavior involved in mating
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb]
is_a: GO:1902435 ! regulation of male mating behavior
relationship: regulates GO:0034607 ! turning behavior involved in mating

[Term]
id: GO:0061095
name: positive regulation of turning behavior involved in mating
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb]
is_a: GO:0061094 ! regulation of turning behavior involved in mating
is_a: GO:1902437 ! positive regulation of male mating behavior
relationship: positively_regulates GO:0034607 ! turning behavior involved in mating

[Term]
id: GO:0061096
name: negative regulation of turning behavior involved in mating
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb]
is_a: GO:0061094 ! regulation of turning behavior involved in mating
is_a: GO:1902436 ! negative regulation of male mating behavior
relationship: negatively_regulates GO:0034607 ! turning behavior involved in mating

[Term]
id: GO:0061097
name: regulation of protein tyrosine kinase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0045859 ! regulation of protein kinase activity
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation

[Term]
id: GO:0061098
name: positive regulation of protein tyrosine kinase activity
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0045860 ! positive regulation of protein kinase activity
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity

[Term]
id: GO:0061099
name: negative regulation of protein tyrosine kinase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity

[Term]
id: GO:0061100
name: lung neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746]
is_a: GO:0061101 ! neuroendocrine cell differentiation
is_a: GO:0061140 ! lung secretory cell differentiation

[Term]
id: GO:0061101
name: neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0061102
name: stomach neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746]
synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0062094 ! stomach development

[Term]
id: GO:0061103
name: carotid body glomus cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia." [GOC:dph, PMID:6243386]
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0061104
name: adrenal chromaffin cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles." [GOC:dph]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0030325 ! adrenal gland development

[Term]
id: GO:0061105
name: regulation of stomach neuroendocrine cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0061102 ! stomach neuroendocrine cell differentiation

[Term]
id: GO:0061106
name: negative regulation of stomach neuroendocrine cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph]
is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation
relationship: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation

[Term]
id: GO:0061107
name: seminal vesicle development
namespace: biological_process
def: "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen." [GOC:dph]
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048732 ! gland development

[Term]
id: GO:0061108
name: seminal vesicle epithelium development
namespace: biological_process
def: "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0061107 ! seminal vesicle development

[Term]
id: GO:0061109
name: dense core granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph]
synonym: "dense core granule organisation" EXACT [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0061110
name: dense core granule biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule." [GOC:dph]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0061111
name: epithelial-mesenchymal cell signaling involved in lung development
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling

[Term]
id: GO:0061112
name: negative regulation of bud outgrowth involved in lung branching
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching." [GOC:dph]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0061048 ! negative regulation of branching involved in lung morphogenesis
relationship: negatively_regulates GO:0060447 ! bud outgrowth involved in lung branching

[Term]
id: GO:0061113
name: pancreas morphogenesis
namespace: biological_process
def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0031016 ! pancreas development

[Term]
id: GO:0061114
name: branching involved in pancreas morphogenesis
namespace: biological_process
def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph]
is_a: GO:0061138 ! morphogenesis of a branching epithelium
relationship: part_of GO:0061113 ! pancreas morphogenesis

[Term]
id: GO:0061115
name: lung proximal/distal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli." [GOC:dph]
is_a: GO:0009946 ! proximal/distal axis specification
is_a: GO:0060432 ! lung pattern specification process

[Term]
id: GO:0061116
name: ductus venosus closure
namespace: biological_process
def: "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth." [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis

[Term]
id: GO:0061117
name: negative regulation of heart growth
namespace: biological_process
def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd]
is_a: GO:0046621 ! negative regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
relationship: negatively_regulates GO:0060419 ! heart growth

[Term]
id: GO:0061118
name: regulation of positive chemotaxis to cAMP
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph]
is_a: GO:0050926 ! regulation of positive chemotaxis
relationship: regulates GO:0043327 ! chemotaxis to cAMP

[Term]
id: GO:0061119
name: regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph, PMID:19684855]
is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP

[Term]
id: GO:0061120
name: regulation of positive chemotaxis to cAMP by DIF-1
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone

[Term]
id: GO:0061121
name: regulation of positive chemotaxis to cAMP by DIF-2
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone

[Term]
id: GO:0061122
name: positive regulation of positive chemotaxis to cAMP
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph]
is_a: GO:0050927 ! positive regulation of positive chemotaxis
is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP
relationship: positively_regulates GO:0043327 ! chemotaxis to cAMP

[Term]
id: GO:0061123
name: negative regulation of positive chemotaxis to cAMP
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph]
is_a: GO:0050928 ! negative regulation of positive chemotaxis
is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP
relationship: negatively_regulates GO:0043327 ! chemotaxis to cAMP

[Term]
id: GO:0061124
name: positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
is_a: GO:0061122 ! positive regulation of positive chemotaxis to cAMP

[Term]
id: GO:0061125
name: negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
is_a: GO:0061123 ! negative regulation of positive chemotaxis to cAMP

[Term]
id: GO:0061126
name: positive regulation of positive chemotaxis to cAMP by DIF-1
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1
is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone

[Term]
id: GO:0061127
name: negative regulation of positive chemotaxis to cAMP by DIF-1
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1
is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone

[Term]
id: GO:0061128
name: positive regulation of chemotaxis to cAMP by DIF-2
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2
is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone

[Term]
id: GO:0061129
name: negative regulation of positive chemotaxis to cAMP by DIF-2
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2
is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone

[Term]
id: GO:0061130
name: pancreatic bud formation
namespace: biological_process
def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph]
is_a: GO:0048645 ! animal organ formation
is_a: GO:0061114 ! branching involved in pancreas morphogenesis
is_a: GO:0072175 ! epithelial tube formation

[Term]
id: GO:0061131
name: pancreas field specification
namespace: biological_process
def: "The process in which a specific region of the gut is delineated into the area in which the pancreas will develop." [GOC:dph]
is_a: GO:0010092 ! specification of animal organ identity
relationship: part_of GO:0061130 ! pancreatic bud formation

[Term]
id: GO:0061132
name: pancreas induction
namespace: biological_process
def: "The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas." [GOC:dph]
is_a: GO:0001759 ! organ induction
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905278 ! positive regulation of epithelial tube formation
relationship: positively_regulates GO:0061131 ! pancreas field specification

[Term]
id: GO:0061133
name: endopeptidase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an endopeptidase." [GOC:dph, GOC:tb]
is_a: GO:0016504 ! peptidase activator activity
is_a: GO:0061135 ! endopeptidase regulator activity

[Term]
id: GO:0061134
name: peptidase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0061135
name: endopeptidase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb]
is_a: GO:0061134 ! peptidase regulator activity

[Term]
id: GO:0061136
name: regulation of proteasomal protein catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process
relationship: regulates GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0061137
name: bud dilation
namespace: biological_process
def: "The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch." [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0001763 ! morphogenesis of a branching structure

[Term]
id: GO:0061138
name: morphogenesis of a branching epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph]
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0061139
name: bud field specification
namespace: biological_process
def: "The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium

[Term]
id: GO:0061140
name: lung secretory cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0061141
name: lung ciliated cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells." [GOC:cilia, GOC:dph, GOC:krc]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0061142
name: mesothelial-mesenchymal cell signaling involved in early lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung." [GOC:dph]
synonym: "mesothelial-mesenchymal cell signalling involved in early lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development

[Term]
id: GO:0061143
name: alveolar primary septum development
namespace: biological_process
def: "The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms." [GOC:dph]
is_a: GO:0060428 ! lung epithelium development
relationship: part_of GO:0060430 ! lung saccule development

[Term]
id: GO:0061144
name: alveolar secondary septum development
namespace: biological_process
def: "The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule." [GOC:dph]
is_a: GO:0060428 ! lung epithelium development
relationship: part_of GO:0060430 ! lung saccule development

[Term]
id: GO:0061145
name: lung smooth muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0048745 ! smooth muscle tissue development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0061146
name: Peyer's patch morphogenesis
namespace: biological_process
def: "The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048541 ! Peyer's patch development

[Term]
id: GO:0061147
name: endocardial endothelium development
namespace: biological_process
def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
is_a: GO:0003158 ! endothelium development
relationship: part_of GO:0003157 ! endocardium development

[Term]
id: GO:0061148
name: extracellular matrix organization involved in endocardium development
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0003157 ! endocardium development

[Term]
id: GO:0061149
name: obsolete BMP signaling pathway involved in ureter morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder." [GOC:dph, GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in ureter morphogenesis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030509
consider: GO:0072197

[Term]
id: GO:0061150
name: renal system segmentation
namespace: biological_process
def: "The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis." [GOC:dph, GOC:yaf]
synonym: "urinary tract segmentation" EXACT [GOC:dph]
is_a: GO:0035282 ! segmentation
is_a: GO:0072048 ! renal system pattern specification

[Term]
id: GO:0061151
name: obsolete BMP signaling pathway involved in renal system segmentation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the segmentation of the renal system." [GOC:dph, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in renal system segmentation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030509
consider: GO:0061150

[Term]
id: GO:0061152
name: trachea submucosa development
namespace: biological_process
def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060438 ! trachea development

[Term]
id: GO:0061153
name: trachea gland development
namespace: biological_process
def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0061152 ! trachea submucosa development

[Term]
id: GO:0061154
name: endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf]
is_a: GO:0003159 ! morphogenesis of an endothelium
is_a: GO:0060562 ! epithelial tube morphogenesis

[Term]
id: GO:0061155
name: pulmonary artery endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf]
is_a: GO:0061154 ! endothelial tube morphogenesis
relationship: part_of GO:0061156 ! pulmonary artery morphogenesis

[Term]
id: GO:0061156
name: pulmonary artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf]
is_a: GO:0048844 ! artery morphogenesis

[Term]
id: GO:0061157
name: mRNA destabilization
namespace: biological_process
def: "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0043488 ! regulation of mRNA stability
is_a: GO:0050779 ! RNA destabilization
is_a: GO:0061014 ! positive regulation of mRNA catabolic process

[Term]
id: GO:0061158
name: 3'-UTR-mediated mRNA destabilization
namespace: biological_process
def: "An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:dph, GOC:jh]
is_a: GO:0061157 ! mRNA destabilization

[Term]
id: GO:0061159
name: establishment of bipolar cell polarity involved in cell morphogenesis
namespace: biological_process
def: "The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]
is_a: GO:0061171 ! establishment of bipolar cell polarity
relationship: part_of GO:0000902 ! cell morphogenesis

[Term]
id: GO:0061160
name: regulation of establishment of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:0061161
name: positive regulation of establishment of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061160 ! regulation of establishment of bipolar cell polarity regulating cell shape
is_a: GO:0061173 ! positive regulation of establishment of bipolar cell polarity
is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:0061162
name: establishment of monopolar cell polarity
namespace: biological_process
def: "The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw]
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity

[Term]
id: GO:0061163
name: endoplasmic reticulum polarization
namespace: biological_process
alt_id: GO:0061164
alt_id: GO:0061165
alt_id: GO:0061166
alt_id: GO:0061167
def: "The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. Endoplasmic reticulum polarization serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [GOC:dph, GOC:vw]
synonym: "endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" NARROW [GOC:mah]
synonym: "endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site" NARROW []
synonym: "ER localization involved in ER polarization at cell division site" NARROW [GOC:dph]
synonym: "ER polarization" EXACT []
synonym: "establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" NARROW [GOC:mah]
synonym: "establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site" NARROW []
synonym: "maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site" NARROW []
synonym: "transitional endoplasmic reticulum polarization at cell division site" NARROW []
is_a: GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0061168
name: regulation of hair follicle placode formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0060789 ! hair follicle placode formation

[Term]
id: GO:0061169
name: positive regulation of hair placode formation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0061168 ! regulation of hair follicle placode formation
relationship: positively_regulates GO:0060789 ! hair follicle placode formation

[Term]
id: GO:0061170
name: negative regulation of hair follicle placode formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph]
is_a: GO:0051799 ! negative regulation of hair follicle development
is_a: GO:0061168 ! regulation of hair follicle placode formation
relationship: negatively_regulates GO:0060789 ! hair follicle placode formation

[Term]
id: GO:0061171
name: establishment of bipolar cell polarity
namespace: biological_process
def: "The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]
is_a: GO:0030010 ! establishment of cell polarity

[Term]
id: GO:0061172
name: regulation of establishment of bipolar cell polarity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]
is_a: GO:2000114 ! regulation of establishment of cell polarity
relationship: regulates GO:0061171 ! establishment of bipolar cell polarity

[Term]
id: GO:0061173
name: positive regulation of establishment of bipolar cell polarity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity." [GOC:dph, GOC:vw]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity
relationship: positively_regulates GO:0061171 ! establishment of bipolar cell polarity

[Term]
id: GO:0061174
name: type I terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc]
synonym: "type I terminal button" EXACT [GOC:dph]
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:0061175
name: type II terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc]
synonym: "type II terminal button" EXACT [GOC:dph]
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:0061176
name: type Ib terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
synonym: "type Ib terminal button" EXACT [GOC:dph]
is_a: GO:0061174 ! type I terminal bouton

[Term]
id: GO:0061177
name: type Is terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc]
synonym: "type Is terminal button" RELATED [GOC:dph]
is_a: GO:0061174 ! type I terminal bouton

[Term]
id: GO:0061178
name: regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph]
synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph]
is_a: GO:0050796 ! regulation of insulin secretion
relationship: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus

[Term]
id: GO:0061179
name: negative regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph]
synonym: "negative regulation of insulin secretion in response to glucose" RELATED [GOC:dph]
synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf]
is_a: GO:0046676 ! negative regulation of insulin secretion
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus
relationship: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus

[Term]
id: GO:0061180
name: mammary gland epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf]
synonym: "breast epithelium development" EXACT [GOC:dph]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0061181
name: regulation of chondrocyte development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0002063 ! chondrocyte development

[Term]
id: GO:0061182
name: negative regulation of chondrocyte development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0032331 ! negative regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
relationship: negatively_regulates GO:0002063 ! chondrocyte development

[Term]
id: GO:0061183
name: regulation of dermatome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0061054 ! dermatome development

[Term]
id: GO:0061184
name: positive regulation of dermatome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
relationship: positively_regulates GO:0061054 ! dermatome development

[Term]
id: GO:0061185
name: negative regulation of dermatome development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
relationship: negatively_regulates GO:0061054 ! dermatome development

[Term]
id: GO:0061186
name: negative regulation of silent mating-type cassette heterochromatin formation
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette." [GOC:dph, PMID:10388812]
synonym: "negative regulation of chromatin silencing at silent mating-type cassette" EXACT []
synonym: "negative regulation of silent mating-type cassette heterochromatin assembly" EXACT []
is_a: GO:0031452 ! negative regulation of heterochromatin formation
is_a: GO:0090054 ! regulation of silent mating-type cassette heterochromatin formation
relationship: negatively_regulates GO:0030466 ! silent mating-type cassette heterochromatin formation

[Term]
id: GO:0061187
name: regulation of rDNA heterochromatin formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of rDNA heterochromatin formation." [PMID:10388812]
synonym: "regulation of chromatin silencing at rDNA" BROAD []
synonym: "regulation of ribosomal DNA heterochromatin assembly" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin formation
relationship: regulates GO:0000183 ! rDNA heterochromatin formation

[Term]
id: GO:0061188
name: negative regulation of rDNA heterochromatin formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of ribosomal DNA heterochromatin formation." [GOC:dph, PMID:10388812]
synonym: "negative regulation of chromatin silencing at rDNA" BROAD []
synonym: "negative regulation of ribosomal DNA heterochromatin assembly" EXACT []
synonym: "negative regulation of ribosomal DNA heterochromatin formation" EXACT []
is_a: GO:0031452 ! negative regulation of heterochromatin formation
is_a: GO:0061187 ! regulation of rDNA heterochromatin formation
relationship: negatively_regulates GO:0000183 ! rDNA heterochromatin formation

[Term]
id: GO:0061189
name: positive regulation of sclerotome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0061190 ! regulation of sclerotome development
relationship: positively_regulates GO:0061056 ! sclerotome development

[Term]
id: GO:0061190
name: regulation of sclerotome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0061056 ! sclerotome development

[Term]
id: GO:0061191
name: positive regulation of vacuole fusion, non-autophagic
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph]
is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic
is_a: GO:0044090 ! positive regulation of vacuole organization
relationship: positively_regulates GO:0042144 ! vacuole fusion, non-autophagic

[Term]
id: GO:0061192
name: negative regulation of vacuole fusion, non-autophagic
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic
relationship: negatively_regulates GO:0042144 ! vacuole fusion, non-autophagic

[Term]
id: GO:0061193
name: taste bud development
namespace: biological_process
def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0043586 ! tongue development

[Term]
id: GO:0061194
name: taste bud morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043587 ! tongue morphogenesis
relationship: part_of GO:0061193 ! taste bud development

[Term]
id: GO:0061195
name: taste bud formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0061194 ! taste bud morphogenesis

[Term]
id: GO:0061196
name: fungiform papilla development
namespace: biological_process
def: "The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043586 ! tongue development

[Term]
id: GO:0061197
name: fungiform papilla morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0043587 ! tongue morphogenesis
relationship: part_of GO:0061196 ! fungiform papilla development

[Term]
id: GO:0061198
name: fungiform papilla formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0061197 ! fungiform papilla morphogenesis

[Term]
id: GO:0061199
name: striated muscle contraction involved in embryonic body morphogenesis
namespace: biological_process
def: "The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology." [GOC:dph, GOC:kmv]
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0010172 ! embryonic body morphogenesis

[Term]
id: GO:0061200
name: clathrin-sculpted gamma-aminobutyric acid transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle." [GOC:dph]
synonym: "clathrin sculpted GABA transport vesicle" EXACT [GOC:dph]
synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle" EXACT [GOC:sl]
is_a: GO:0060198 ! clathrin-sculpted vesicle

[Term]
id: GO:0061201
name: clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph]
synonym: "clathrin sculpted GABA transport vesicle lumen" EXACT [GOC:dph]
synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle

[Term]
id: GO:0061202
name: clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph]
synonym: "clathrin sculpted GABA transport vesicle membrane" EXACT [GOC:dph]
synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle

[Term]
id: GO:0061203
name: striated muscle paramyosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle." [GOC:dph, GOC:kmv]
is_a: GO:0061204 ! paramyosin filament assembly or disassembly
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0061204
name: paramyosin filament assembly or disassembly
namespace: biological_process
def: "The formation or disassembly of a filament composed of paramyosin molecules." [GOC:dph, GOC:kmv]
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0061205
name: paramesonephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph, GOC:yaf]
synonym: "Mullerian duct development" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035295 ! tube development

[Term]
id: GO:0061206
name: mesonephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephros are generated and organized." [GOC:mtg_kidney_jan10]
synonym: "Wolffian body morphogenesis" EXACT [GOC:dph]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061207
name: mesonephric juxtaglomerulus cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072052 ! juxtaglomerulus cell differentiation
relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development

[Term]
id: GO:0061208
name: cell differentiation involved in mesonephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061209
name: cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061210
name: cell-cell signaling involved in mesonephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in mesonephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061211
name: mesonephric collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061212
name: mesonephric juxtaglomerular apparatus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10]
is_a: GO:0072051 ! juxtaglomerular apparatus development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061213
name: positive regulation of mesonephros development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090184 ! positive regulation of kidney development
relationship: positively_regulates GO:0001823 ! mesonephros development

[Term]
id: GO:0061214
name: mesonephric smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072194 ! kidney smooth muscle tissue development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061215
name: mesonephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061216
name: obsolete regulation of transcription from RNA polymerase II promoter involved in mesonephros development
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the mesonephros progressing from its initial formation to the mature state." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0061217
name: regulation of mesonephros development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0001823 ! mesonephros development

[Term]
id: GO:0061218
name: negative regulation of mesonephros development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090185 ! negative regulation of kidney development
relationship: negatively_regulates GO:0001823 ! mesonephros development

[Term]
id: GO:0061219
name: mesonephric mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061220
name: mesonephric macula densa development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0061241 ! mesonephric nephron epithelium development
is_a: GO:0072024 ! macula densa development
relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development

[Term]
id: GO:0061221
name: mesonephric mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0061219 ! mesonephric mesenchyme development

[Term]
id: GO:0061222
name: mesonephric mesenchymal cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population." [GOC:mtg_kidney_jan10]
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
is_a: GO:0072135 ! kidney mesenchymal cell proliferation
relationship: part_of GO:0061219 ! mesonephric mesenchyme development

[Term]
id: GO:0061223
name: mesonephric mesenchymal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development
relationship: part_of GO:0061219 ! mesonephric mesenchyme development

[Term]
id: GO:0061224
name: mesonephric glomerulus development
namespace: biological_process
def: "The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0032835 ! glomerulus development
relationship: part_of GO:0061215 ! mesonephric nephron development

[Term]
id: GO:0061225
name: mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10]
synonym: "mesonephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "mesonephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
is_a: GO:0072122 ! extraglomerular mesangial cell proliferation
relationship: part_of GO:0061215 ! mesonephric nephron development

[Term]
id: GO:0061226
name: proximal/distal pattern formation involved in mesonephric nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end)." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development
relationship: part_of GO:0061215 ! mesonephric nephron development

[Term]
id: GO:0061227
name: pattern specification involved in mesonephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "mesonephros pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "mesonephros pattern specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061228
name: mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0061206 ! mesonephros morphogenesis
relationship: part_of GO:0061215 ! mesonephric nephron development

[Term]
id: GO:0061229
name: mesonephric juxtaglomerulus cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072142 ! juxtaglomerulus cell development
relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation

[Term]
id: GO:0061230
name: mesonephric juxtaglomerulus cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072150 ! juxtaglomerulus cell fate commitment
relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation

[Term]
id: GO:0061231
name: mesonephric glomerulus vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072012 ! glomerulus vasculature development
relationship: part_of GO:0061224 ! mesonephric glomerulus development

[Term]
id: GO:0061232
name: mesonephric glomerular epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0061241 ! mesonephric nephron epithelium development
is_a: GO:0072010 ! glomerular epithelium development
relationship: part_of GO:0061224 ! mesonephric glomerulus development

[Term]
id: GO:0061233
name: mesonephric glomerular basement membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10]
is_a: GO:0032836 ! glomerular basement membrane development
relationship: part_of GO:0061224 ! mesonephric glomerulus development

[Term]
id: GO:0061234
name: mesonephric glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072102 ! glomerulus morphogenesis
relationship: part_of GO:0061224 ! mesonephric glomerulus development
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061235
name: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061236
name: mesonephric comma-shaped body morphogenesis
namespace: biological_process
def: "The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072049 ! comma-shaped body morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061237
name: convergent extension involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061238
name: establishment of planar polarity involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "establishment of planar cell polarity involved in mesonephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10]
is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061239
name: mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061240
name: mesonephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
relationship: part_of GO:0061242 ! mesonephric nephron tubule development

[Term]
id: GO:0061241
name: mesonephric nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072163 ! mesonephric epithelium development
relationship: part_of GO:0061215 ! mesonephric nephron development

[Term]
id: GO:0061242
name: mesonephric nephron tubule development
namespace: biological_process
def: "The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0061241 ! mesonephric nephron epithelium development
is_a: GO:0072080 ! nephron tubule development
is_a: GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0061243
name: mesonephric renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072077 ! renal vesicle morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061244
name: mesonephric S-shaped body morphogenesis
namespace: biological_process
def: "The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072050 ! S-shaped body morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:0061245
name: establishment or maintenance of bipolar cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw]
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0061246
name: establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity
is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape

[Term]
id: GO:0061247
name: mesonephric glomerular mesangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072109 ! glomerular mesangium development
relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development

[Term]
id: GO:0061248
name: mesonephric glomerulus vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072103 ! glomerulus vasculature morphogenesis
relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development
relationship: part_of GO:0061234 ! mesonephric glomerulus morphogenesis

[Term]
id: GO:0061249
name: mesonephric glomerular capillary formation
namespace: biological_process
def: "The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10]
is_a: GO:0072104 ! glomerular capillary formation
relationship: part_of GO:0061248 ! mesonephric glomerulus vasculature morphogenesis

[Term]
id: GO:0061250
name: mesonephric glomerular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072311 ! glomerular epithelial cell differentiation
relationship: part_of GO:0061232 ! mesonephric glomerular epithelium development

[Term]
id: GO:0061251
name: mesonephric glomerular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation

[Term]
id: GO:0061252
name: mesonephric glomerular epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072314 ! glomerular epithelial cell fate commitment
relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation

[Term]
id: GO:0061253
name: mesonephric glomerular parietal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation
is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation

[Term]
id: GO:0061254
name: mesonephric glomerular parietal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0061251 ! mesonephric glomerular epithelial cell development
is_a: GO:0072016 ! glomerular parietal epithelial cell development
relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation

[Term]
id: GO:0061255
name: mesonephric glomerular parietal epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10]
is_a: GO:0061252 ! mesonephric glomerular epithelial cell fate commitment
is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment
relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation

[Term]
id: GO:0061256
name: mesonephric podocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric glomerular visceral epithelial cell differentiation" EXACT []
is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation
is_a: GO:0072112 ! podocyte differentiation

[Term]
id: GO:0061257
name: mesonephric podocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric glomerular visceral epithelial cell development" EXACT []
is_a: GO:0061251 ! mesonephric glomerular epithelial cell development
is_a: GO:0072015 ! podocyte development
relationship: part_of GO:0061256 ! mesonephric podocyte differentiation

[Term]
id: GO:0061258
name: mesonephric podocyte cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric glomerular visceral epithelial cell fate commitment" EXACT []
is_a: GO:0061251 ! mesonephric glomerular epithelial cell development
is_a: GO:0072149 ! podocyte cell fate commitment
relationship: part_of GO:0061256 ! mesonephric podocyte differentiation

[Term]
id: GO:0061259
name: mesonephric glomerular mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061260 ! mesonephric mesangial cell differentiation
is_a: GO:0072008 ! glomerular mesangial cell differentiation
relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development

[Term]
id: GO:0061260
name: mesonephric mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072007 ! mesangial cell differentiation

[Term]
id: GO:0061261
name: mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric mesenchyme to epithelial transition" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0060231 ! mesenchymal to epithelial transition
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
relationship: part_of GO:0061206 ! mesonephros morphogenesis

[Term]
id: GO:0061262
name: mesonephric renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072033 ! renal vesicle formation
relationship: part_of GO:0061243 ! mesonephric renal vesicle morphogenesis

[Term]
id: GO:0061263
name: mesonephric glomerular mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072144 ! glomerular mesangial cell development
relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation

[Term]
id: GO:0061264
name: mesonephric glomerular mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072152 ! glomerular mesangial cell fate commitment
relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation

[Term]
id: GO:0061265
name: mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: part_of GO:0061242 ! mesonephric nephron tubule development

[Term]
id: GO:0061266
name: mesonephric interstitial fibroblast differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "mesonephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072071 ! kidney interstitial fibroblast differentiation

[Term]
id: GO:0061267
name: mesonephric interstitial fibroblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "mesonephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072141 ! renal interstitial fibroblast development
relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation

[Term]
id: GO:0061268
name: mesonephric interstitial fibroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast." [GOC:mtg_kidney_jan10]
is_a: GO:0072153 ! renal interstitial fibroblast fate commitment
relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation

[Term]
id: GO:0061269
name: mesonephric glomerular mesangial cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10]
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
is_a: GO:0072110 ! glomerular mesangial cell proliferation
relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development

[Term]
id: GO:0061270
name: mesonephric intraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10]
is_a: GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
is_a: GO:0072123 ! intraglomerular mesangial cell proliferation

[Term]
id: GO:0061271
name: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation
relationship: part_of GO:0061262 ! mesonephric renal vesicle formation

[Term]
id: GO:0061272
name: mesonephric connecting tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric collecting tubule development" EXACT [GOC:dph]
synonym: "mesonephric connecting duct development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061242 ! mesonephric nephron tubule development
is_a: GO:0072027 ! connecting tubule development

[Term]
id: GO:0061273
name: mesonephric distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis
is_a: GO:0072156 ! distal tubule morphogenesis
relationship: part_of GO:0061274 ! mesonephric distal tubule development

[Term]
id: GO:0061274
name: mesonephric distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061242 ! mesonephric nephron tubule development
is_a: GO:0072017 ! distal tubule development

[Term]
id: GO:0061275
name: mesonephric proximal tubule development
namespace: biological_process
def: "The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061242 ! mesonephric nephron tubule development
is_a: GO:0072014 ! proximal tubule development

[Term]
id: GO:0061276
name: mesonephric proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis
is_a: GO:0072158 ! proximal tubule morphogenesis
relationship: part_of GO:0061275 ! mesonephric proximal tubule development

[Term]
id: GO:0061277
name: mesonephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072172 ! mesonephric tubule formation
relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis

[Term]
id: GO:0061278
name: epithelial cell migration involved in mesonephric nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis

[Term]
id: GO:0061279
name: epithelial cell migration involved in mesonephric distal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis
is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis
relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis

[Term]
id: GO:0061280
name: epithelial cell migration involved in mesonephric proximal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis
is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis
relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis

[Term]
id: GO:0061281
name: specification of mesonephric connecting tubule identity
namespace: biological_process
def: "The process in which the connecting tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
synonym: "specification of mesonephric collecting tubule identity" EXACT [GOC:dph]
is_a: GO:0061282 ! specification of mesonephric nephron tubule identity
is_a: GO:0072085 ! specification of connecting tubule identity
relationship: part_of GO:0061272 ! mesonephric connecting tubule development

[Term]
id: GO:0061282
name: specification of mesonephric nephron tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0061226 ! proximal/distal pattern formation involved in mesonephric nephron development
relationship: part_of GO:0061277 ! mesonephric nephron tubule formation

[Term]
id: GO:0061283
name: specification of mesonephric distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061282 ! specification of mesonephric nephron tubule identity
is_a: GO:0072084 ! specification of distal tubule identity
relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis

[Term]
id: GO:0061284
name: specification of mesonephric proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061282 ! specification of mesonephric nephron tubule identity
is_a: GO:0072082 ! specification of proximal tubule identity
relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis

[Term]
id: GO:0061285
name: mesonephric capsule development
namespace: biological_process
def: "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [GOC:mtg_kidney_jan10]
is_a: GO:0072127 ! renal capsule development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0061286
name: mesonephric capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072128 ! renal capsule morphogenesis
relationship: part_of GO:0061285 ! mesonephric capsule development

[Term]
id: GO:0061287
name: mesonephric capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072129 ! renal capsule formation
relationship: part_of GO:0061286 ! mesonephric capsule morphogenesis

[Term]
id: GO:0061288
name: mesonephric capsule specification
namespace: biological_process
def: "The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072130 ! renal capsule specification
relationship: part_of GO:0061287 ! mesonephric capsule formation

[Term]
id: GO:0061289
name: obsolete Wnt signaling pathway involved in kidney development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in kidney development" EXACT []
synonym: "Wnt receptor signalling pathway involved in kidney development" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in kidney development" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0001822
consider: GO:0016055

[Term]
id: GO:0061290
name: obsolete canonical Wnt signaling pathway involved in metanephric kidney development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in metanephric kidney development" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in metanephric kidney development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in metanephric kidney development" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0001656
consider: GO:0060070

[Term]
id: GO:0061291
name: obsolete canonical Wnt signaling pathway involved in ureteric bud branching
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in ureteric bud branching" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in ureteric bud branching" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0060070

[Term]
id: GO:0061292
name: obsolete canonical Wnt signaling pathway involved in mesonephros development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in mesonephros development" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in mesonephros development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in mesonephros development" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0001823
consider: GO:0035567

[Term]
id: GO:0061293
name: obsolete canonical Wnt signaling pathway involved in mesonephric nephron development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in mesonephric nephron development" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in mesonephric nephron development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in mesonephric nephron development" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060070
consider: GO:0061215

[Term]
id: GO:0061294
name: mesonephric renal vesicle induction
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0072034 ! renal vesicle induction
relationship: positively_regulates GO:0061262 ! mesonephric renal vesicle formation

[Term]
id: GO:0061295
name: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

[Term]
id: GO:0061296
name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: negatively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

[Term]
id: GO:0061297
name: positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: positively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

[Term]
id: GO:0061298
name: retina vasculature development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature development" EXACT [GOC:dph]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0061299
name: retina vasculature morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0061298 ! retina vasculature development in camera-type eye

[Term]
id: GO:0061300
name: cerebellum vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0001944 ! vasculature development

[Term]
id: GO:0061301
name: cerebellum vasculature morphogenesis
namespace: biological_process
def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0061300 ! cerebellum vasculature development

[Term]
id: GO:0061302
name: smooth muscle cell-matrix adhesion
namespace: biological_process
def: "The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules." [GOC:BHF, GOC:dph, PMID:8837777]
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0061303
name: cornea development in camera-type eye
namespace: biological_process
def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0061304
name: retinal blood vessel morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
is_a: GO:0048514 ! blood vessel morphogenesis
is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye

[Term]
id: GO:0061305
name: maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:0061306
name: obsolete DNA strand renaturation involved in double-strand break repair
namespace: biological_process
def: "OBSOLETE. The identification and annealing of complementary base pairs in single-strand DNA that contributes to double-strand break repair." [GOC:dph]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006302
consider: GO:0036310

[Term]
id: GO:0061307
name: cardiac neural crest cell differentiation involved in heart development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442]
is_a: GO:0014033 ! neural crest cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:0061308
name: cardiac neural crest cell development involved in heart development
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0014032 ! neural crest cell development
relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development

[Term]
id: GO:0061309
name: cardiac neural crest cell development involved in outflow tract morphogenesis
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0061310
name: obsolete canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation." [GOC:dph, GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0007507
consider: GO:0060070

[Term]
id: GO:0061311
name: cell surface receptor signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling]
synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf]
synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0061312
name: obsolete BMP signaling pathway involved in heart development
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in heart development" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007507
consider: GO:0030509

[Term]
id: GO:0061313
name: fibroblast growth factor receptor signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time." [GOC:mtg_heart]
synonym: "fibroblast growth factor receptor signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development

[Term]
id: GO:0061314
name: Notch signaling involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time." [GOC:mtg_heart]
synonym: "Notch signalling involved in heart development" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development

[Term]
id: GO:0061315
name: obsolete canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "OBSOLETE. The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060045
consider: GO:0060070

[Term]
id: GO:0061316
name: canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart]
synonym: "canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0003306 ! Wnt signaling pathway involved in heart development
is_a: GO:0060070 ! canonical Wnt signaling pathway

[Term]
id: GO:0061317
name: obsolete canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart, PMID:17576928]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060070
consider: GO:0060923

[Term]
id: GO:0061318
name: renal filtration cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0061319
name: nephrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002520, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0061318 ! renal filtration cell differentiation

[Term]
id: GO:0061320
name: pericardial nephrocyte differentiation
namespace: biological_process
alt_id: GO:0007513
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
synonym: "pericardial cell differentiation" NARROW []
is_a: GO:0061319 ! nephrocyte differentiation

[Term]
id: GO:0061321
name: garland nephrocyte differentiation
namespace: biological_process
alt_id: GO:0007514
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
synonym: "garland cell differentiation" EXACT []
is_a: GO:0061319 ! nephrocyte differentiation
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0061322
name: disseminated nephrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002524, GOC:19783135, GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0061319 ! nephrocyte differentiation

[Term]
id: GO:0061323
name: cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0061324
name: obsolete canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
namespace: biological_process
def: "OBSOLETE. The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells." [GOC:dph, GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060038
consider: GO:0060070

[Term]
id: GO:0061325
name: cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0061326
name: renal tubule development
namespace: biological_process
def: "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0061327
name: anterior Malpighian tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0072002 ! Malpighian tubule development

[Term]
id: GO:0061328
name: posterior Malpighian tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0072002 ! Malpighian tubule development

[Term]
id: GO:0061329
name: Malpighian tubule principal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0072002 ! Malpighian tubule development

[Term]
id: GO:0061330
name: Malpighian tubule stellate cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0072002 ! Malpighian tubule development

[Term]
id: GO:0061331
name: epithelial cell proliferation involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:2001013 ! epithelial cell proliferation involved in renal tubule morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0061332
name: Malpighian tubule bud morphogenesis
namespace: biological_process
def: "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
synonym: "Malpighian tubule formation" EXACT [GOC:dph]
is_a: GO:0060572 ! morphogenesis of an epithelial bud
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0061333
name: renal tubule morphogenesis
namespace: biological_process
def: "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0061326 ! renal tubule development

[Term]
id: GO:0061334
name: cell rearrangement involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "cell migration involved in Malpighian tubule morphogenesis" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0061335
name: cell growth involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0061336
name: cell morphogenesis involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0061337
name: cardiac conduction
namespace: biological_process
def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph]
is_a: GO:0008016 ! regulation of heart contraction

[Term]
id: GO:0061338
name: obsolete atrioventricular node impulse conduction delay
namespace: biological_process
def: "OBSOLETE. A heart process that modulates the propagation of the signal that causes the heart muscle to contract." [GOC:dph]
comment: This term was made obsolete because it was created before the cardiac conduction overhaul, and represents a measurement rather than a process.
synonym: "atrioventricular node impulse conduction delay" EXACT []
is_obsolete: true
consider: GO:0086016

[Term]
id: GO:0061339
name: establishment or maintenance of monopolar cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw]
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0061340
name: establishment or maintenance of monopolar cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity
is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape

[Term]
id: GO:0061341
name: non-canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, PMID:16860783]
synonym: "non-canonical Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "non-canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "non-canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0003306 ! Wnt signaling pathway involved in heart development
is_a: GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:0061342
name: obsolete regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart." [PMID:16860783]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003007
consider: GO:0030155
consider: GO:0035567

[Term]
id: GO:0061343
name: cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0007155 ! cell adhesion
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0061344
name: regulation of cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis

[Term]
id: GO:0061345
name: planar cell polarity pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development

[Term]
id: GO:0061346
name: obsolete planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0061347
name: obsolete planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart, PMID:19056682]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0061348
name: obsolete planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum." [GOC:dph, GOC:mtg_heart, PMID:19056682]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0061349
name: obsolete planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium." [GOC:dph, GOC:mtg_heart, PMID:19056682]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0061350
name: obsolete planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue." [GOC:dph, GOC:mtg_heart, PMID:19056682]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0061351
name: neural precursor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0061352
name: cell chemotaxis involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0060326 ! cell chemotaxis
is_a: GO:0061334 ! cell rearrangement involved in Malpighian tubule morphogenesis

[Term]
id: GO:0061353
name: obsolete BMP signaling pathway involved in Malpighian tubule cell chemotaxis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "bone morphogenic protein receptor signalling pathway involved in Malpighian tubule cell chemotaxis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030509
consider: GO:0061352

[Term]
id: GO:0061354
name: obsolete planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium." [GOC:dph, GOC:mtg_heart, PMID:19056682]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0061355
name: Wnt protein secretion
namespace: biological_process
def: "The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0009306 ! protein secretion
is_a: GO:0023061 ! signal release

[Term]
id: GO:0061356
name: regulation of Wnt protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0061355 ! Wnt protein secretion

[Term]
id: GO:0061357
name: positive regulation of Wnt protein secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0061356 ! regulation of Wnt protein secretion
relationship: positively_regulates GO:0061355 ! Wnt protein secretion

[Term]
id: GO:0061358
name: negative regulation of Wnt protein secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0061356 ! regulation of Wnt protein secretion
relationship: negatively_regulates GO:0061355 ! Wnt protein secretion

[Term]
id: GO:0061359
name: obsolete regulation of Wnt signaling pathway by Wnt protein secretion
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell." [GOC:bf, GOC:jl, PMID:19223472]
comment: This term was obsoleted because it is a specific target of protein secretion ; GO:0009306.
synonym: "regulation of Wnt receptor signaling pathway by Wnt protein secretion" EXACT []
synonym: "regulation of Wnt receptor signalling pathway by Wnt protein secretion" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway by Wnt protein secretion" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0009306

[Term]
id: GO:0061360
name: optic chiasma development
namespace: biological_process
def: "The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature." [GOC:dph]
synonym: "optic chiasm development" EXACT [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021554 ! optic nerve development

[Term]
id: GO:0061361
name: positive regulation of maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph]
is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: positively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:0061362
name: negative regulation of maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph]
is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000750 ! negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: negatively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:0061363
name: negative regulation of progesterone biosynthesis involved in luteolysis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis." [GOC:dph]
synonym: "functional luteolysis" EXACT [GOC:dph]
is_a: GO:2000183 ! negative regulation of progesterone biosynthetic process
relationship: part_of GO:0001554 ! luteolysis

[Term]
id: GO:0061364
name: apoptotic process involved in luteolysis
namespace: biological_process
def: "The apoptotic process that contributes to luteolysis." [GOC:mtg_apoptosis, PMID:18566128]
synonym: "apoptosis involved in luteolysis" NARROW []
synonym: "structural luteolysis" EXACT [GOC:dph]
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0001554 ! luteolysis

[Term]
id: GO:0061365
name: positive regulation of triglyceride lipase activity
namespace: biological_process
def: "Any process that increases the activity of triglyceride lipase." [GOC:dph]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of TAG activity" EXACT [PMID:16054079]
is_a: GO:0060193 ! positive regulation of lipase activity

[Term]
id: GO:0061366
name: behavioral response to chemical pain
namespace: biological_process
def: "Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus." [GOC:dph]
is_a: GO:0007635 ! chemosensory behavior
is_a: GO:0048266 ! behavioral response to pain

[Term]
id: GO:0061367
name: behavioral response to acetic acid induced pain
namespace: biological_process
def: "Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus." [GOC:dph]
is_a: GO:0061366 ! behavioral response to chemical pain

[Term]
id: GO:0061368
name: behavioral response to formalin induced pain
namespace: biological_process
def: "Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus." [GOC:dph]
is_a: GO:0061366 ! behavioral response to chemical pain

[Term]
id: GO:0061369
name: negative regulation of testicular blood vessel morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle." [GOC:BHF, GOC:dph]
synonym: "negative regulation of testicular vasculature morphogenesis" BROAD [GOC:BHF, GOC:dph]
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis

[Term]
id: GO:0061370
name: testosterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph, GOC:yaf]
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0061371
name: determination of heart left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the heart with respect to the left and right halves of the organism." [GOC:dph, GOC:mtg_heart]
synonym: "determination of cardiac left/right asymmetry" EXACT [GOC:dph]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0061372
name: obsolete activin receptor signaling pathway involved in heart jogging
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the activin family to its receptor on the surface of a target cell, and contributing to the process of heart jogging." [GOC:dph, GOC:mtg_heart, GOC:signaling]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activin receptor signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0032924

[Term]
id: GO:0061373
name: mammillary axonal complex development
namespace: biological_process
def: "The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021767 ! mammillary body development

[Term]
id: GO:0061374
name: mammillothalamic axonal tract development
namespace: biological_process
def: "The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061373 ! mammillary axonal complex development

[Term]
id: GO:0061375
name: mammillotectal axonal tract development
namespace: biological_process
def: "The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061373 ! mammillary axonal complex development

[Term]
id: GO:0061376
name: mammillotegmental axonal tract development
namespace: biological_process
def: "The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061373 ! mammillary axonal complex development

[Term]
id: GO:0061377
name: mammary gland lobule development
namespace: biological_process
def: "The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0061378
name: corpora quadrigemina development
namespace: biological_process
def: "The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:0061379
name: inferior colliculus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061378 ! corpora quadrigemina development

[Term]
id: GO:0061380
name: superior colliculus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061378 ! corpora quadrigemina development

[Term]
id: GO:0061381
name: cell migration in diencephalon
namespace: biological_process
def: "The orderly movement of a cell that will reside in the diencephalon." [GOC:dph]
is_a: GO:0021885 ! forebrain cell migration
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0061382
name: Malpighian tubule tip cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0072002 ! Malpighian tubule development

[Term]
id: GO:0061383
name: trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0061384
name: heart trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
is_a: GO:0061383 ! trabecula morphogenesis

[Term]
id: GO:0061385
name: fibroblast proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph]
is_a: GO:0048144 ! fibroblast proliferation
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis

[Term]
id: GO:0061386
name: closure of optic fissure
namespace: biological_process
def: "The closure of the temporary ventral gap in the optic cup that contributes to its shaping." [GOC:dph]
synonym: "closure or choriod fissure" RELATED [GOC:dph]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development

[Term]
id: GO:0061387
name: regulation of extent of cell growth
namespace: biological_process
def: "Any process that modulates the extent of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0001558 ! regulation of cell growth
relationship: part_of GO:0008361 ! regulation of cell size

[Term]
id: GO:0061388
name: regulation of rate of cell growth
namespace: biological_process
def: "Any process that modulates the rate of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0001558 ! regulation of cell growth

[Term]
id: GO:0061389
name: regulation of direction of cell growth
namespace: biological_process
def: "Any process that modulates the direction of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0008360 ! regulation of cell shape

[Term]
id: GO:0061390
name: positive regulation of direction of cell growth
namespace: biological_process
def: "Any process that increases the direction of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0061389 ! regulation of direction of cell growth

[Term]
id: GO:0061391
name: negative regulation of direction of cell growth
namespace: biological_process
def: "Any process that decreases the direction of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0061389 ! regulation of direction of cell growth

[Term]
id: GO:0061392
name: obsolete regulation of transcription from RNA polymerase II promoter in response to osmotic stress
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0071470

[Term]
id: GO:0061393
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:0071470

[Term]
id: GO:0061394
name: obsolete regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
namespace: biological_process
def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0071722

[Term]
id: GO:0061395
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:0071722

[Term]
id: GO:0061396
name: obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0071280

[Term]
id: GO:0061397
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to copper ion
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:0071280

[Term]
id: GO:0061398
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to copper ion
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:0071280

[Term]
id: GO:0061399
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:0061400
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to calcium ion
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0061401
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:0071476

[Term]
id: GO:0061402
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7." [GOC:dph, GOC:go_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to acidity" BROAD []
is_obsolete: true
consider: GO:0045944
consider: GO:0071468

[Term]
id: GO:0061403
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:0071500

[Term]
id: GO:0061404
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to increased salt
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:0071472

[Term]
id: GO:0061405
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:0061406
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0042149
consider: GO:0045944

[Term]
id: GO:0061407
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0034599
consider: GO:0045944

[Term]
id: GO:0061408
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to heat stress
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0034605
consider: GO:0045944

[Term]
id: GO:0061409
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to freezing
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:dph]
comment: This term was obsoleted because this is not a GO process.
is_obsolete: true

[Term]
id: GO:0061410
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to ethanol
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:0061411
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to cold
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045945
consider: GO:0070417

[Term]
id: GO:0061412
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0034198
consider: GO:0045944

[Term]
id: GO:0061413
name: regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
namespace: biological_process
def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0061414
name: positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
namespace: biological_process
def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338]
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter
is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source

[Term]
id: GO:0061415
name: negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
namespace: biological_process
def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338]
is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter
is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source

[Term]
id: GO:0061416
name: obsolete regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0071472

[Term]
id: GO:0061417
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:dph, PMID:9767597]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:0034599

[Term]
id: GO:0061418
name: obsolete regulation of transcription from RNA polymerase II promoter in response to hypoxia
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:12511571]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0006357

[Term]
id: GO:0061419
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:0061420
name: obsolete regulation of transcription from RNA polymerase II promoter in response to biotin starvation
namespace: biological_process
def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin." [GOC:dph, PMID:16533810]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0061421
name: obsolete positive regulation of transcription by oleic acid
namespace: biological_process
def: "OBSOLETE. Any process involving oleic acid that activates or increases the rate of transcription." [GOC:dph, PMID:20395639]
comment: This term was obsoleted because it it not different from its child positive regulation of transcription from RNA polymerase II promoter by oleic acid ; GO:0061429.
is_obsolete: true

[Term]
id: GO:0061422
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0." [GOC:dph, PMID:11523797, PMID:15299026, PMID:21749328]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to alkalinity" BROAD []
is_obsolete: true
consider: GO:0045944
consider: GO:0071469

[Term]
id: GO:0061423
name: obsolete positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, PMID:11523797]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944
consider: GO:1902307

[Term]
id: GO:0061424
name: obsolete positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization." [GOC:dph, PMID:7500953]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of peroxisome organisation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0061425
name: obsolete positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process." [GOC:dph, PMID:10608811, PMID:7760841]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0061426
name: obsolete positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport." [GOC:dph, PMID:10234785, PMID:10870099]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:1900071

[Term]
id: GO:0061427
name: obsolete negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter and stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph, PMID:15302821]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0061428
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:17785431]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0000122

[Term]
id: GO:0061429
name: positive regulation of transcription from RNA polymerase II promoter by oleic acid
namespace: biological_process
def: "Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dph, PMID:20395639]
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter

[Term]
id: GO:0061430
name: bone trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:BHF, GOC:dph, GOC:vk]
is_a: GO:0061383 ! trabecula morphogenesis

[Term]
id: GO:0061431
name: cellular response to methionine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GOC:dph, PMID:7891681]
is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904640 ! response to methionine

[Term]
id: GO:0061432
name: obsolete regulation of transcription from RNA polymerase II promoter in response to methionine
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a methionine stimulus." [GOC:dph, PMID:7891681]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0061433
name: cellular response to caloric restriction
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake." [GOC:dph, PMID:17914901]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0061771 ! response to caloric restriction

[Term]
id: GO:0061434
name: obsolete regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus." [GOC:dph, PMID:17914901]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0090398

[Term]
id: GO:0061435
name: positive regulation of transcription from a mobile element promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter." [GOC:dph, PMID:12230120, PMID:9271107]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription

[Term]
id: GO:0061436
name: establishment of skin barrier
namespace: biological_process
def: "Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability." [GOC:dph]
synonym: "epithelial barrier development" RELATED [GOC:dph]
synonym: "establishment of epithelial barrier" BROAD [GOC:dph]
synonym: "skin barrier development" RELATED [GOC:dph]
is_a: GO:0098773 ! skin epidermis development

[Term]
id: GO:0061437
name: renal system vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0061438
name: renal system vasculature morphogenesis
namespace: biological_process
def: "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0061437 ! renal system vasculature development

[Term]
id: GO:0061439
name: kidney vasculature morphogenesis
namespace: biological_process
def: "The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0061438 ! renal system vasculature morphogenesis
relationship: part_of GO:0061440 ! kidney vasculature development

[Term]
id: GO:0061440
name: kidney vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0061437 ! renal system vasculature development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0061441
name: renal artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood." [GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0048844 ! artery morphogenesis
relationship: part_of GO:0061439 ! kidney vasculature morphogenesis

[Term]
id: GO:0061442
name: cardiac muscle cell fate determination
namespace: biological_process
def: "The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph]
is_a: GO:0007521 ! muscle cell fate determination
is_a: GO:0060913 ! cardiac cell fate determination
relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment

[Term]
id: GO:0061443
name: endocardial cushion cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell." [GOC:BHF, GOC:dph]
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0003197 ! endocardial cushion development

[Term]
id: GO:0061444
name: endocardial cushion cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state." [GOC:BHF, GOC:dph]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0061443 ! endocardial cushion cell differentiation

[Term]
id: GO:0061445
name: endocardial cushion cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell." [GOC:BHF, GOC:dph]
is_a: GO:0060957 ! endocardial cell fate commitment
relationship: part_of GO:0061443 ! endocardial cushion cell differentiation

[Term]
id: GO:0061446
name: endocardial cushion cell fate determination
namespace: biological_process
def: "The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph]
is_a: GO:0060913 ! cardiac cell fate determination
relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment

[Term]
id: GO:0061447
name: endocardial cushion cell fate specification
namespace: biological_process
def: "The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:BHF, GOC:dph]
is_a: GO:0060912 ! cardiac cell fate specification
relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment

[Term]
id: GO:0061448
name: connective tissue development
namespace: biological_process
def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0061449
name: olfactory bulb tufted cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0061450
name: trophoblast cell migration
namespace: biological_process
def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0007566 ! embryo implantation

[Term]
id: GO:0061451
name: retrotrapezoid nucleus development
namespace: biological_process
def: "The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration." [GOC:dph]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0061452
name: retrotrapezoid nucleus neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus." [GOC:dph]
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0061451 ! retrotrapezoid nucleus development

[Term]
id: GO:0061453
name: interstitial cell of Cajal differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph]
synonym: "ICC differentiation" RELATED [GOC:dph]
is_a: GO:0060563 ! neuroepithelial cell differentiation
is_a: GO:0060575 ! intestinal epithelial cell differentiation

[Term]
id: GO:0061454
name: release of sequestered calcium ion into cytosol by Golgi
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol." [GOC:dph, GOC:tb]
synonym: "Golgi calcium ion export" BROAD []
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0061856 ! Golgi calcium ion transmembrane transport

[Term]
id: GO:0061455
name: obsolete integral component of muscle cell projection membrane
namespace: cellular_component
def: "OBSOLETE. The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to muscle cell projection membrane" EXACT []
is_obsolete: true
replaced_by: GO:0036195

[Term]
id: GO:0061456
name: mesenchymal stem cell migration involved in uteric bud morphogenesis
namespace: biological_process
def: "The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:dph, GOC:tb]
is_a: GO:0035787 ! cell migration involved in kidney development
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0061457
name: mesonephric cell migration involved in male gonad development
namespace: biological_process
def: "The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development." [GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0061458
name: reproductive system development
namespace: biological_process
def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph]
is_a: GO:0048731 ! system development

[Term]
id: GO:0061459
name: L-arginine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005288
alt_id: GO:0015181
alt_id: GO:0015598
alt_id: GO:0102022
def: "Enables the transfer of L-arginine from one side of a membrane to the other." [GOC:dph]
synonym: "arginine permease activity" BROAD []
synonym: "arginine porter activity" NARROW []
synonym: "arginine transmembrane transporter activity" EXACT []
synonym: "arginine-importing ATPase activity" NARROW []
synonym: "ATP-dependent L-arginine transmembrane transporter activity" NARROW []
synonym: "ATPase-coupled L-arginine transmembrane transporter activity" NARROW []
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-arginine transporter activity" EXACT []
synonym: "L-arginine-importing ATPase activity" NARROW []
xref: MetaCyc:RXN66-448
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0061462
name: protein localization to lysosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]
is_a: GO:0072665 ! protein localization to vacuole

[Term]
id: GO:0061463
name: O-acetyl-ADP-ribose deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. Removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose." [EC:3.1.1.106]
xref: EC:3.1.1.106
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0061464
name: obsolete plasma membrane part of cell-substrate junction
namespace: cellular_component
def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell-substrate junction." [GOC:dph]
comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM.
is_obsolete: true

[Term]
id: GO:0061465
name: obsolete plasma membrane part of hemidesmosome
namespace: cellular_component
def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a hemidesmosome." [GOC:dph]
comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM.
is_obsolete: true

[Term]
id: GO:0061466
name: obsolete plasma membrane part of cell junction
namespace: cellular_component
def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell junction." [GOC:dph]
comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM.
is_obsolete: true

[Term]
id: GO:0061468
name: karyomere
namespace: cellular_component
def: "A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division." [GOC:dph, PMID:12734396, PMID:22863006]
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0061469
name: regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation." [GOC:dph]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0044342 ! type B pancreatic cell proliferation

[Term]
id: GO:0061470
name: T follicular helper cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell." [GOC:dph, PMID:21572431]
synonym: "T-helper follicular cell differentiation" EXACT [GOC:dph]
is_a: GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0061471
name: karyomere assembly
namespace: biological_process
def: "The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle." [GOC:dph, PMID:9732278]
is_a: GO:0070925 ! organelle assembly
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly

[Term]
id: GO:0061472
name: karyomere membrane fusion
namespace: biological_process
def: "Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus." [GOC:dph, PMID:2734396]
is_a: GO:0090174 ! organelle membrane fusion
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly

[Term]
id: GO:0061473
name: murein tripeptide carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate." [GOC:dph, PMID:22970852]
is_a: GO:0004181 ! metallocarboxypeptidase activity

[Term]
id: GO:0061474
name: phagolysosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a phagolysosome." [GOC:dph, PMID:22073313]
is_a: GO:0005765 ! lysosomal membrane
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0032010 ! phagolysosome

[Term]
id: GO:0061475
name: cytosolic valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:dph]
is_a: GO:0006438 ! valyl-tRNA aminoacylation

[Term]
id: GO:0061476
name: response to anticoagulant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0061477
name: response to aromatase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0061478
name: response to platelet aggregation inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0061479
name: response to reverse transcriptase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus." [GOC:dph]
is_a: GO:0046677 ! response to antibiotic

[Term]
id: GO:0061480
name: response to asparaginase
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0061481
name: response to TNF agonist
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0061482
name: response to irinotecan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0061483
name: obsolete sulfinylpropanyl adenylate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate." [GOC:dph, PMID:8346915]
comment: The reason for obsoletion is that this term does not represent a physiological function.
synonym: "SPA synthase activity" RELATED [PMID:8346915]
is_obsolete: true

[Term]
id: GO:0061484
name: hematopoietic stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411]
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0061485
name: memory T cell proliferation
namespace: biological_process
def: "The expansion of a memory T cell population by cell division." [GOC:dph, PMID:14647273]
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0061486
name: high-affinity fructose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:dph, PMID:10735857]
synonym: "high affinity fructose transmembrane transporter activity" EXACT []
is_a: GO:0005353 ! fructose transmembrane transporter activity

[Term]
id: GO:0061487
name: obsolete DNA replication initiation from late origin
namespace: biological_process
def: "OBSOLETE. The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase." [GOC:dph, PMID:19221029]
comment: The reason for obsoletion is that there is no evidence that this is a different process from its parent term (DNA replication initiation, GO:0006270), but only that regulation of initiation at late origins differs from regulation of initiation at early origins.
synonym: "late replication origin firing" EXACT [GOC:dph, PMID:19221029]
is_obsolete: true
consider: GO:0101017

[Term]
id: GO:0061492
name: asymmetric protein localization to old or new spindle pole body
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, PMID:22119525]
is_a: GO:0071988 ! protein localization to spindle pole body

[Term]
id: GO:0061493
name: central plaque of mitotic spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body." [GOC:dph]
is_a: GO:0005823 ! central plaque of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body

[Term]
id: GO:0061496
name: half bridge of mitotic spindle pole body
namespace: cellular_component
def: "Structure adjacent to the plaques of the mitotic spindle pole body." [GOC:dph]
is_a: GO:0005825 ! half bridge of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body

[Term]
id: GO:0061497
name: inner plaque of mitotic spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus." [GOC:dph, GOC:vw]
is_a: GO:0005822 ! inner plaque of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body

[Term]
id: GO:0061498
name: intermediate layer of mitotic spindle pole body
namespace: cellular_component
def: "Structure between the central and outer plaques of the mitotic spindle pole body." [GOC:dph]
is_a: GO:0005821 ! intermediate layer of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body

[Term]
id: GO:0061499
name: outer plaque of mitotic spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm." [GOC:dph]
is_a: GO:0005824 ! outer plaque of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body

[Term]
id: GO:0061501
name: 2',3'-cyclic GMP-AMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP)." [GOC:dph, PMID:23258413, RHEA:42064]
synonym: "2',3' cyclic GMP-AMP synthase activity" EXACT []
synonym: "2',3' cyclic-GMP-AMP synthase activity" EXACT []
synonym: "cyclic 2',3' GAMP synthase activity" EXACT []
synonym: "cyclic-GMP-AMP synthase activity" BROAD []
xref: EC:2.7.7.86
xref: Reactome:R-HSA-3244614 "cGAS produces cyclic GMP-AMP"
xref: RHEA:42064
is_a: GO:0140699 ! cyclic GMP-AMP synthase activity

[Term]
id: GO:0061502
name: early endosome to recycling endosome transport
namespace: biological_process
def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes." [GOC:dph, GOC:kmv, PMID:21474295]
is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments

[Term]
id: GO:0061503
name: tRNA threonylcarbamoyladenosine dehydratase
namespace: molecular_function
def: "Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A." [GOC:dph, PMID:23242255]
is_a: GO:0016836 ! hydro-lyase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0061504
name: cyclic threonylcarbamoyladenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [PMID:23242255]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0061506
name: obsolete DNA topoisomerase type II (ATP-independent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:dph]
comment: This term was made obsolete because there is no evidence that this function exists. There are no known type II topoisomerase enzymes that are ATP-independent; as far as we know, ALL type II topoisomerase enzymes utilize hydrolysis of ATP.
is_obsolete: true

[Term]
id: GO:0061507
name: 2',3'-cyclic GMP-AMP binding
namespace: molecular_function
alt_id: GO:0098546
def: "Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages." [GOC:dph, PMID:23258412, PMID:23910378]
synonym: "2',3' cGAMP binding" EXACT []
synonym: "2',3' cyclic GAMP binding" EXACT []
synonym: "2',3'-cGAMP binding" EXACT []
synonym: "2',3'-cyclic GAMP binding" EXACT []
synonym: "2',5-3',5'-cyclic GMP-AMP binding" EXACT []
synonym: "c[G(2',5')pA(3',5')p] binding" EXACT [PMID:23910378]
synonym: "cyclic-GMP-AMP binding" BROAD []
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0140702 ! cyclic GMP-AMP binding

[Term]
id: GO:0061508
name: obsolete CDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into CDP to produce a CTP." [PMID:7499258]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0061509
name: asymmetric protein localization to old mitotic spindle pole body
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw]
is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body
is_a: GO:1902440 ! protein localization to mitotic spindle pole body

[Term]
id: GO:0061510
name: asymmetric protein localization to new mitotic spindle pole body
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw]
is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body
is_a: GO:1902440 ! protein localization to mitotic spindle pole body

[Term]
id: GO:0061511
name: centriole elongation
namespace: biological_process
def: "The centrosome organization process by which a centriole increases in length as part of the process of replication." [GOC:dph, PMID:21576394]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007099 ! centriole replication

[Term]
id: GO:0061512
name: protein localization to cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0061513
name: glucose 6-phosphate:phosphate antiporter activity
namespace: molecular_function
alt_id: GO:0008524
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [GOC:dph, PMID:18337460]
synonym: "glucose 6-phosphate:inorganic phosphate antiporter activity" EXACT []
xref: MetaCyc:TRANS-RXN-33
xref: Reactome:R-HSA-198513 "SLC7A4 exchanges G6P for Pi across the ER membrane"
xref: Reactome:R-HSA-3229118 "Defective SLC37A4 does not exchange G6P and Pi across the ER membrane"
xref: Reactome:R-HSA-3257122 "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane"
xref: RHEA:71535
is_a: GO:0015152 ! glucose-6-phosphate transmembrane transporter activity
is_a: GO:0015526 ! hexose-phosphate:phosphate antiporter activity

[Term]
id: GO:0061514
name: interleukin-34-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-34 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dph, PMID:18467591]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0061515
name: myeloid cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0030097 ! hemopoiesis
relationship: part_of GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0061516
name: monocyte proliferation
namespace: biological_process
def: "The expansion of a monocyte population by cell division." [GOC:dph, PMID:18467591]
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0061517
name: macrophage proliferation
namespace: biological_process
def: "The expansion of a macrophage population by cell division." [GOC:dph, PMID:12614284, PMID:19466391]
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0061518
name: microglial cell proliferation
namespace: biological_process
def: "The expansion of a microglial cell population by cell division." [GOC:dph, PMID:17344397]
is_a: GO:0014009 ! glial cell proliferation
is_a: GO:0061517 ! macrophage proliferation

[Term]
id: GO:0061519
name: macrophage homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:dph, PMID:21727904]
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0061520
name: Langerhans cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a Langerhans cell." [GOC:dph, PMID:22729249]
is_a: GO:0043011 ! myeloid dendritic cell differentiation

[Term]
id: GO:0061521
name: hepatic stellate cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell." [GOC:dph, PMID:9407545]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0061522
name: 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+." [RHEA:26309]
xref: EC:3.1.2.28
xref: RHEA:26309
is_a: GO:0016289 ! acyl-CoA hydrolase activity

[Term]
id: GO:0061523
name: cilium disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "cilium resorption" EXACT [GOC:dph]
is_a: GO:0044782 ! cilium organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0061524
name: central canal development
namespace: biological_process
def: "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [GOC:cvs, GOC:dph, PMID:23409159]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0061525
name: hindgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph]
is_a: GO:0048565 ! digestive tract development

[Term]
id: GO:0061526
name: acetylcholine secretion
namespace: biological_process
def: "The regulated release of acetylcholine by a cell." [GOC:dph]
is_a: GO:0015870 ! acetylcholine transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0061527
name: dopamine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0099124 ! axonal dopamine secretion
is_a: GO:0160043 ! catecholamine secretion, neurotransmission
relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0061528
name: aspartate secretion
namespace: biological_process
def: "The regulated release of aspartate by a cell." [GOC:dph]
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0061529
name: epinephrine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter." [GOC:dph]
synonym: "adrenaline secretion, neurotransmission" EXACT [GOC:dph]
is_a: GO:0048242 ! epinephrine secretion
is_a: GO:0160043 ! catecholamine secretion, neurotransmission

[Term]
id: GO:0061530
name: aspartate secretion, neurotransmission
namespace: biological_process
def: "The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061528 ! aspartate secretion

[Term]
id: GO:0061531
name: primary amine secretion
namespace: biological_process
def: "The regulated release of a primary amine by a cell." [GOC:dph]
is_a: GO:0015837 ! amine transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0061532
name: primary amine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061531 ! primary amine secretion

[Term]
id: GO:0061533
name: norepinephrine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph]
synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph]
is_a: GO:0048243 ! norepinephrine secretion
is_a: GO:0160043 ! catecholamine secretion, neurotransmission

[Term]
id: GO:0061534
name: gamma-aminobutyric acid secretion, neurotransmission
namespace: biological_process
def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014051 ! gamma-aminobutyric acid secretion
relationship: part_of GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0061535
name: glutamate secretion, neurotransmission
namespace: biological_process
def: "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014047 ! glutamate secretion
is_a: GO:0051938 ! L-glutamate import
relationship: part_of GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0061536
name: glycine secretion
namespace: biological_process
def: "The controlled release of glycine by a cell." [GOC:dph]
is_a: GO:0015816 ! glycine transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0061537
name: glycine secretion, neurotransmission
namespace: biological_process
def: "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061536 ! glycine secretion
relationship: part_of GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0061538
name: histamine secretion, neurotransmission
namespace: biological_process
def: "The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0001821 ! histamine secretion
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015801 ! aromatic amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0061539
name: octopamine secretion
namespace: biological_process
def: "The controlled release of octopamine by a cell." [GOC:dph]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0061540
name: octopamine secretion, neurotransmission
namespace: biological_process
def: "The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061539 ! octopamine secretion

[Term]
id: GO:0061541
name: rhabdomere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [GOC:dph, PMID:22113834]
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0008594 ! photoreceptor cell morphogenesis
relationship: part_of GO:0042052 ! rhabdomere development

[Term]
id: GO:0061542
name: 3-demethylubiquinol-n 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol." [GOC:dph, PMID:10777520, PMID:23190198, RHEA:44380]
comment: Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
synonym: "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase" NARROW []
synonym: "5-demethylubiquinone-10 methyltransferase" NARROW []
synonym: "5-demethylubiquinone-9 methyltransferase" NARROW []
synonym: "OMHMB-methyltransferase" RELATED []
synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase" RELATED []
xref: EC:2.1.1.64
xref: Reactome:R-HSA-2162186 "COQ3 methylates DeMQ10H2"
xref: RHEA:44380
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0061543
name: obsolete 3-demethylubiquinol-6 3-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6." [GOC:dph]
comment: This term was obsoleted because it represents a specific substrate of 3-demethylubiquinol-n 3-O-methyltransferase activity ; GO:0061542.
is_obsolete: true
replaced_by: GO:0061542

[Term]
id: GO:0061544
name: peptide secretion, neurotransmission
namespace: biological_process
def: "The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter." [GOC:dph]
is_a: GO:0002790 ! peptide secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0061545
name: tyramine secretion
namespace: biological_process
def: "The regulated release of a tyramine by a cell." [GOC:dph]
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0061531 ! primary amine secretion

[Term]
id: GO:0061546
name: tyramine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0061532 ! primary amine secretion, neurotransmission
is_a: GO:0061545 ! tyramine secretion

[Term]
id: GO:0061547
name: glycogen synthase activity, transferring glucose-1-phosphate
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate." [GOC:dph, PMID:21356517]
xref: Reactome:R-HSA-3780994 "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2"
xref: Reactome:R-HSA-3781024 "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0061548
name: ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "ganglia development" RELATED [GOC:dph]
synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0061549
name: sympathetic ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl]
synonym: "sympathetic ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
relationship: part_of GO:0048485 ! sympathetic nervous system development

[Term]
id: GO:0061550
name: cranial ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "cranial ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
relationship: part_of GO:0021545 ! cranial nerve development

[Term]
id: GO:0061551
name: trigeminal ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "trigeminal ganglia development" RELATED [GOC:dph]
is_a: GO:0061550 ! cranial ganglion development

[Term]
id: GO:0061552
name: ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph]
synonym: "ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0061548 ! ganglion development

[Term]
id: GO:0061553
name: ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph]
synonym: "ganglia maturation" RELATED [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0061548 ! ganglion development

[Term]
id: GO:0061554
name: ganglion formation
namespace: biological_process
def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "ganglia formation" RELATED [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0061552 ! ganglion morphogenesis

[Term]
id: GO:0061555
name: ganglion structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph]
synonym: "ganglia structural organization" RELATED [GOC:dph]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0061552 ! ganglion morphogenesis

[Term]
id: GO:0061556
name: trigeminal ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph]
synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061559 ! cranial ganglion morphogenesis
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis
relationship: part_of GO:0061551 ! trigeminal ganglion development

[Term]
id: GO:0061557
name: trigeminal ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph]
synonym: "trigeminal ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061558 ! cranial ganglion maturation
relationship: part_of GO:0021635 ! trigeminal nerve maturation
relationship: part_of GO:0061551 ! trigeminal ganglion development

[Term]
id: GO:0061558
name: cranial ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph]
synonym: "cranial ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061553 ! ganglion maturation
relationship: part_of GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0061550 ! cranial ganglion development

[Term]
id: GO:0061559
name: cranial ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph]
synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061552 ! ganglion morphogenesis
relationship: part_of GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0061550 ! cranial ganglion development

[Term]
id: GO:0061560
name: cranial ganglion formation
namespace: biological_process
def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "cranial ganglia formation" RELATED [GOC:dph]
is_a: GO:0061554 ! ganglion formation
relationship: part_of GO:0061559 ! cranial ganglion morphogenesis

[Term]
id: GO:0061561
name: trigeminal ganglion formation
namespace: biological_process
def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "trigeminal ganglia formation" RELATED [GOC:dph]
is_a: GO:0061560 ! cranial ganglion formation
relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis

[Term]
id: GO:0061562
name: cranial ganglion structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph]
synonym: "cranial ganglia structural organization" RELATED [GOC:dph]
is_a: GO:0061555 ! ganglion structural organization
relationship: part_of GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0061559 ! cranial ganglion morphogenesis

[Term]
id: GO:0061563
name: trigeminal ganglion structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure." [GOC:dph]
synonym: "trigeminal ganglia organization" RELATED [GOC:dph]
is_a: GO:0061562 ! cranial ganglion structural organization
relationship: part_of GO:0021637 ! trigeminal nerve structural organization
relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis

[Term]
id: GO:0061564
name: axon development
namespace: biological_process
def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]
is_a: GO:0031175 ! neuron projection development

[Term]
id: GO:0061565
name: dAMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP." [GOC:dph, PMID:23416111]
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation

[Term]
id: GO:0061566
name: CMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP." [GOC:dph, PMID:23416111]
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation

[Term]
id: GO:0061567
name: dCMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP." [GOC:dph, PMID:23416111]
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation

[Term]
id: GO:0061568
name: obsolete GDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP." [GOC:dph, PMID:23416111]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0061569
name: obsolete UDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP." [GOC:dph, PMID:23416111]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0061570
name: obsolete dCDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into dCDP to produce a dCTP." [GOC:dph, PMID:23416111]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0061571
name: obsolete TDP phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into TDP to produce a TTP." [GOC:dph, PMID:23416111]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:0061572
name: actin filament bundle organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph]
synonym: "actin filament cable organization" RELATED [GOC:dph]
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0061573
name: actin filament bundle retrograde transport
namespace: biological_process
def: "A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell." [GOC:dph]
synonym: "actin filament cable retrograde transport" RELATED [GOC:dph]
is_a: GO:0070650 ! actin filament bundle distribution

[Term]
id: GO:0061574
name: ASAP complex
namespace: cellular_component
def: "A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1." [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0061575
name: cyclin-dependent protein serine/threonine kinase activator activity
namespace: molecular_function
alt_id: GO:0016534
alt_id: GO:0016535
def: "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]
synonym: "cyclin-dependent protein kinase 5 activator activity" NARROW []
is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity
is_a: GO:0043539 ! protein serine/threonine kinase activator activity

[Term]
id: GO:0061576
name: acyl-CoA ceramide synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1." [GOC:dph, PMID:15692566]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0061577
name: calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel." [GOC:dph]
synonym: "generation of L-type calcium current" RELATED []
is_a: GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0061578
name: K63-linked deubiquitinase activity
namespace: molecular_function
def: "Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin." [GOC:dph, GOC:pg, PMID:18313383]
synonym: "K63-specific deubiquitinase activity" EXACT []
synonym: "Lys63-specific deubiquitinase activity" EXACT []
xref: Reactome:R-HSA-5357845 "K63polyUb-RIPK1 is deubiquitinated"
xref: Reactome:R-HSA-5690856 "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1"
xref: Reactome:R-HSA-5691411 "BRCA1-A complex deubiquitinates K63polyUb-histone H2A"
xref: Reactome:R-HSA-5691431 "PSMD14 cleaves K63-linked ubiquitin"
xref: Reactome:R-HSA-5691439 "BRISC complex deubiquitinates NLRP3"
xref: Reactome:R-HSA-5696547 "STAMBPL1 is a deubiquitinase"
xref: Reactome:R-HSA-688136 "TNFAIP3 (A20) deubiquitinates RIP2"
xref: Reactome:R-HSA-741411 "CYLD deubiquitinates NEMO"
xref: Reactome:R-HSA-8869506 "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6"
xref: Reactome:R-HSA-936381 "OTUD5 deubiquitinates TRAF3"
xref: Reactome:R-HSA-936390 "CYLD mediated deubiquitination of DDX58 (RIG-I)"
xref: Reactome:R-HSA-9685219 "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)"
xref: Reactome:R-HSA-9711016 "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING"
xref: Reactome:R-HSA-9750942 "USP14 deubiquitinates NLRC5"
xref: Reactome:R-HSA-9817400 "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex"
is_a: GO:0101005 ! deubiquitinase activity

[Term]
id: GO:0061579
name: N-acyl homoserine lactone synthase activity
namespace: molecular_function
def: "Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone." [GOC:dph]
synonym: "autoinducer-1 synthase" RELATED [GOC:dph]
xref: EC:2.3.1.184
xref: RHEA:10096
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0061580
name: colon epithelial cell migration
namespace: biological_process
def: "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0061582 ! intestinal epithelial cell migration

[Term]
id: GO:0061581
name: corneal epithelial cell migration
namespace: biological_process
def: "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0010631 ! epithelial cell migration

[Term]
id: GO:0061582
name: intestinal epithelial cell migration
namespace: biological_process
def: "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0010631 ! epithelial cell migration

[Term]
id: GO:0061583
name: colon epithelial cell chemotaxis
namespace: biological_process
def: "The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]
is_a: GO:0060326 ! cell chemotaxis
is_a: GO:0061580 ! colon epithelial cell migration

[Term]
id: GO:0061584
name: orexin secretion
namespace: biological_process
def: "The controlled release of orexin from a cell or a tissue." [GOC:dph]
synonym: "hypocretin secretion" EXACT []
is_a: GO:0002790 ! peptide secretion

[Term]
id: GO:0061585
name: orexin secretion, neurotransmission
namespace: biological_process
def: "The controlled release of orexin from a cell in which orexin acts as a neurotransmitter." [GOC:dph]
synonym: "hypocretin secretion, neurotransmission" EXACT []
is_a: GO:0061544 ! peptide secretion, neurotransmission
is_a: GO:0061584 ! orexin secretion

[Term]
id: GO:0061586
name: positive regulation of transcription by transcription factor localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph]
is_a: GO:0008104 ! protein localization
is_a: GO:0045893 ! positive regulation of DNA-templated transcription

[Term]
id: GO:0061587
name: obsolete tRNA locus-associated negative regulation of gene expression
namespace: biological_process
def: "OBSOLETE. The chromatin silencing process that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes." [GOC:dph, PMID:23707796, PMID:30362930, PMID:30718362]
comment: This term was obsoleted because there is no evidence that it is a separate process.
synonym: "tDNA-mediated gene silencing" EXACT []
synonym: "tgm silencing" EXACT [PMID:23707796]
synonym: "transfer RNA gene-mediated chromatin silencing" EXACT [GOC:dph]
synonym: "transfer RNA gene-mediated gene silencing" EXACT [GOC:dph]
synonym: "transfer RNA gene-mediated silencinga" EXACT []
synonym: "tRNA gene-mediated chromatin silencing" EXACT [GOC:dph]
synonym: "tRNA gene-mediated gene silencing" EXACT [GOC:dph]
is_obsolete: true

[Term]
id: GO:0061588
name: calcium activated phospholipid scrambling
namespace: biological_process
def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0017121 ! plasma membrane phospholipid scrambling

[Term]
id: GO:0061589
name: calcium activated phosphatidylserine scrambling
namespace: biological_process
def: "The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0061588 ! calcium activated phospholipid scrambling

[Term]
id: GO:0061590
name: calcium activated phosphatidylcholine scrambling
namespace: biological_process
def: "The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0061588 ! calcium activated phospholipid scrambling

[Term]
id: GO:0061591
name: calcium activated galactosylceramide scrambling
namespace: biological_process
def: "The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0061588 ! calcium activated phospholipid scrambling

[Term]
id: GO:0061592
name: phosphatidylserine exposure on osteoblast involved in bone mineralization
namespace: biological_process
def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization." [GOC:krc, PMID:22936354]
is_a: GO:0017121 ! plasma membrane phospholipid scrambling
relationship: part_of GO:0030282 ! bone mineralization

[Term]
id: GO:0061593
name: sulfoquinovose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose." [GOC:dph, PMID:24463506]
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0061594
name: 6-deoxy-6-sulfofructose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP." [PMID:24463506]
xref: EC:2.7.1.184
xref: MetaCyc:RXN-15297
xref: RHEA:40443
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0061595
name: 6-deoxy-6-sulfofructose-1-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate." [PMID:24463506]
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0061596
name: 3-sulfolactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+." [EC:1.1.1.373, GOC:dph, PMID:24463506]
xref: EC:1.1.1.373
xref: MetaCyc:RXN-15299
xref: RHEA:40511
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0061597
name: obsolete cyclic pyranopterin monophosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate." [EC:4.1.99.18, GOC:dph, PMID:18154309]
comment: This term was made obsolete because it represents two distinct molecular functions.
is_obsolete: true

[Term]
id: GO:0061598
name: molybdopterin adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin." [EC:2.7.7.75, GOC:dph]
xref: EC:2.7.7.75
xref: RHEA:31331
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0061599
name: molybdopterin molybdotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP." [EC:2.10.1.1, GOC:dph]
xref: EC:2.10.1.1
xref: Reactome:R-HSA-947531 "Molybdenum ion transfer onto molybdopterin"
xref: RHEA:35047
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0061602
name: molybdenum cofactor cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor." [EC:2.7.7.76, GOC:dph]
xref: EC:2.7.7.76
xref: RHEA:31335
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0061603
name: molybdenum cofactor guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor." [EC:2.7.7.77, GOC:dph]
xref: EC:2.7.7.77
xref: RHEA:34243
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0061604
name: molybdopterin-synthase sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186]
xref: EC:2.8.1.11
xref: RHEA:48612
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0061605
name: molybdopterin-synthase adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186]
xref: EC:2.7.7.80
xref: RHEA:43616
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0061606
name: N-terminal protein amino acid propionylation
namespace: biological_process
def: "The propionylation of the N-terminal amino acid of proteins." [GOC:dph, PMID:17267393, PMID:23043182]
subset: gocheck_obsoletion_candidate
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0061607
name: peptide alpha-N-propionyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein." [GOC:dph, PMID:23043182]
synonym: "N-terminal propionyltransferase activity" EXACT [PMID:23043182]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0061608
name: nuclear import signal receptor activity
namespace: molecular_function
def: "Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]
synonym: "importin activity" RELATED []
is_a: GO:0140142 ! nucleocytoplasmic carrier activity

[Term]
id: GO:0061609
name: fructose-1-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose-1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate." [GOC:dph, GOC:glycolysis, ISBN:0201090910, RHEA:30851]
xref: MetaCyc:RXN-8631
xref: Reactome:R-HSA-5656438 "Defective ALDOB does not cleave Fru 1-P to GA and DHAP"
xref: Reactome:R-HSA-70342 "ALDOB tetramer cleaves Fru-1-P to GA and DHAP"
xref: RHEA:30851
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0061610
name: glycerol to glycerone phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate." [GOC:dph, ISBN:0201090910]
synonym: "glycerol metabolism to DHAP" EXACT [GOC:dph]
synonym: "glycerol metabolism to dihydroxyacetone phosphate" EXACT [GOC:dph]
synonym: "glycerol metabolism to glycerone phosphate" EXACT [GOC:dph]
synonym: "glycerol to DHAP metabolic process" EXACT [GOC:dph]
synonym: "glycerol to dihydroxyacetone phosphate metabolic process" EXACT [GOC:dph]
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0061611
name: mannose to fructose-6-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
synonym: "mannose metabolism to fructose-6-phosphate" EXACT [GOC:dph]
is_a: GO:0006002 ! fructose 6-phosphate metabolic process
is_a: GO:0019309 ! mannose catabolic process

[Term]
id: GO:0061612
name: galactose to glucose-1-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
is_a: GO:0006012 ! galactose metabolic process

[Term]
id: GO:0061613
name: glycolytic process from glycerol
namespace: biological_process
def: "The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH." [GOC:dph, ISBN:0201090910]
is_a: GO:0006096 ! glycolytic process
is_a: GO:0019563 ! glycerol catabolic process

[Term]
id: GO:0061614
name: miRNA transcription
namespace: biological_process
def: "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799]
synonym: "microRNA gene transcription" EXACT []
synonym: "miRNA gene transcription" EXACT []
synonym: "pri-miRNA transcription by RNA polymerase II" EXACT []
synonym: "pri-miRNA transcription from RNA polymerase II promoter" EXACT []
synonym: "primary miRNA gene transcription" EXACT []
is_a: GO:0006351 ! DNA-templated transcription
is_a: GO:0010586 ! miRNA metabolic process

[Term]
id: GO:0061615
name: glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
synonym: "glycolysis through fructose-6-phosphate" EXACT [GOC:dph]
xref: MetaCyc:PWY-5484
is_a: GO:0006096 ! glycolytic process

[Term]
id: GO:0061616
name: glycolytic process from fructose through fructose-6-phosphate
namespace: biological_process
def: "The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
synonym: "glycolysis from fructose through fructose-6-phosphate" EXACT [GOC:dph]
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate

[Term]
id: GO:0061617
name: MICOS complex
namespace: cellular_component
def: "Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]
synonym: "Fcj1 complex" EXACT [GOC:dph]
synonym: "MINOS complex" EXACT [GOC:dph]
synonym: "mitochondrial contact site and cristae organizing system" EXACT [GOC:dph]
synonym: "MitOS complex" EXACT [GOC:dph]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:0061618
name: obsolete sublamina densa
namespace: cellular_component
def: "OBSOLETE. The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers." [GOC:BHF, PMID:15623520]
comment: This term was made obsolete because it is thought to be an experimental artefact.
is_obsolete: true

[Term]
id: GO:0061619
name: glycolytic process from mannose through fructose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
is_a: GO:0019309 ! mannose catabolic process
is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate

[Term]
id: GO:0061620
name: glycolytic process through glucose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate

[Term]
id: GO:0061621
name: canonical glycolysis
namespace: biological_process
def: "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
xref: MetaCyc:ANAGLYCOLYSIS-PWY
xref: Wikipedia:Glycolysis
is_a: GO:0006735 ! NADH regeneration
is_a: GO:0019677 ! NAD catabolic process
is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate
is_a: GO:0061718 ! glucose catabolic process to pyruvate

[Term]
id: GO:0061622
name: glycolytic process through glucose-1-phosphate
namespace: biological_process
def: "The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910]
is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate

[Term]
id: GO:0061623
name: glycolytic process from galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910]
is_a: GO:0019388 ! galactose catabolic process
is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate

[Term]
id: GO:0061624
name: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate." [GOC:dph, ISBN:0201090910]
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process

[Term]
id: GO:0061625
name: glycolytic process through fructose-1-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910]
xref: MetaCyc:PWY-8404
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0006096 ! glycolytic process

[Term]
id: GO:0061626
name: pharyngeal arch artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914]
synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph]
is_a: GO:0048844 ! artery morphogenesis
relationship: part_of GO:0060037 ! pharyngeal system development

[Term]
id: GO:0061627
name: S-methylmethionine-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+." [RHEA:26337]
synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10]
synonym: "methylmethionine:homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "S-methylmethionine homocysteine transmethylase activity" RELATED [EC:2.1.1.10]
xref: MetaCyc:MMUM-RXN
xref: Reactome:R-HSA-5696838 "BHMT2 tetramer transfers CH3 group from SMM to LHCYS"
xref: RHEA:26337
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0061628
name: H3K27me3 histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone H3 trimethylated at lysine 27." [GOC:dph, PMID:23948251]
synonym: "H3-K27me3 modified histone binding" NARROW []
synonym: "H3K27me3 modified histone binding" NARROW []
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:0061629
name: RNA polymerase II-specific DNA-binding transcription factor binding
namespace: molecular_function
alt_id: GO:0001085
alt_id: GO:0001102
alt_id: GO:0001103
def: "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]
synonym: "RNA polymerase II activating transcription factor binding" RELATED []
synonym: "RNA polymerase II repressing transcription factor binding" RELATED []
synonym: "RNA polymerase II sequence-specific DNA binding transcription factor binding" EXACT []
synonym: "RNA polymerase II sequence-specific DNA-binding transcription factor binding" EXACT []
synonym: "RNA polymerase II transcription factor binding" RELATED []
is_a: GO:0140297 ! DNA-binding transcription factor binding

[Term]
id: GO:0061630
name: ubiquitin protein ligase activity
namespace: molecular_function
alt_id: GO:0090302
alt_id: GO:0090622
alt_id: GO:1904264
alt_id: GO:1904822
def: "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]
comment: This enzyme catalyzes a transferase reaction.
synonym: "E3" BROAD [GOC:dph]
synonym: "ER-associated E3 ligase" RELATED [PMID:24019521]
synonym: "protein ubiquitination activity" EXACT [GOC:dph]
synonym: "ubiquitin ligase activity" EXACT [GOC:dph]
xref: Reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL"
xref: Reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1"
xref: Reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)"
xref: Reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8"
xref: Reactome:R-HSA-3322429 "XIAP monoubiquinates TLE"
xref: Reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN"
xref: Reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1"
xref: Reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2"
xref: Reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1"
xref: Reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization"
xref: Reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation"
xref: Reactome:R-HSA-5246693 "APC is K63-polyubiquitinated"
xref: Reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1"
xref: Reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1"
xref: Reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3"
xref: Reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1"
xref: Reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1"
xref: Reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2"
xref: Reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3"
xref: Reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4"
xref: Reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1"
xref: Reactome:R-HSA-5674022 "BRAP autoubiquitinates"
xref: Reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX"
xref: Reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1"
xref: Reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal"
xref: Reactome:R-HSA-5689111 "PARK2 autoubiquitinates"
xref: Reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1"
xref: Reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II"
xref: Reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC"
xref: Reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI"
xref: Reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC"
xref: Reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2"
xref: Reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY"
xref: Reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53"
xref: Reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4"
xref: Reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53"
xref: Reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate"
xref: Reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination"
xref: Reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN"
xref: Reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin"
xref: Reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex"
xref: Reactome:R-HSA-8848829 "CBL autoubiquitinates"
xref: Reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN"
xref: Reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA"
xref: Reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7"
xref: Reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839"
xref: Reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR"
xref: Reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del"
xref: Reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5"
xref: Reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET"
xref: Reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination"
xref: Reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET"
xref: Reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex"
xref: Reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC"
xref: Reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA"
xref: Reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10"
xref: Reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2"
xref: Reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B"
xref: Reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA"
xref: Reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA"
xref: Reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11"
xref: Reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN"
xref: Reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN"
xref: Reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3"
xref: Reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3"
xref: Reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11"
xref: Reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5"
xref: Reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73"
xref: Reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2"
xref: Reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2"
xref: Reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2"
xref: Reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1"
xref: Reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3"
xref: Reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11"
xref: Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL"
xref: Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation"
xref: Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216"
xref: Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4"
xref: Reactome:R-HSA-9685195 "SARS-CoV-1 9b recruits ITCH to MAVS"
xref: Reactome:R-HSA-9686920 "PELI1 ubiquitinates RIPK3 at K363"
xref: Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2"
xref: Reactome:R-HSA-9705738 "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7"
xref: Reactome:R-HSA-9706354 "Ubiquitination of FLT3"
xref: Reactome:R-HSA-9706356 "CBL mutants don't ubiquitinate FLT3"
xref: Reactome:R-HSA-9708517 "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))"
xref: Reactome:R-HSA-9733316 "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL"
xref: Reactome:R-HSA-9755304 "MUL1 ubiquitinates UBXN7"
xref: Reactome:R-HSA-9755505 "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2"
xref: Reactome:R-HSA-9759154 "TRIM21 ubiquitinates SQSTM1"
xref: Reactome:R-HSA-9759172 "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer"
xref: Reactome:R-HSA-9762091 "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1"
xref: Reactome:R-HSA-9766645 "CUL3:RBX1 ubiquitinates KEAP1"
xref: Reactome:R-HSA-990526 "Recruitment of ITCH and K48 ubiquitination of MAVS"
is_a: GO:0004842 ! ubiquitin-protein transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0061631
name: ubiquitin conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]
synonym: "E2" BROAD [GOC:dph]
synonym: "HECT E3" RELATED [GOC:dph]
xref: EC:2.3.2.23
is_a: GO:0004842 ! ubiquitin-protein transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0061632
name: RNA lariat debranching enzyme activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an RNA lariat debranching enzyme." [GOC:dph, PMID:24919400]
is_a: GO:0170054 ! ribonuclease activator activity

[Term]
id: GO:0061633
name: transport-coupled glycolytic process through glucose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport." [GOC:dph]
xref: MetaCyc:GLYCOLYSIS
is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate
is_a: GO:0061718 ! glucose catabolic process to pyruvate

[Term]
id: GO:0061634
name: alpha-D-xyloside xylohydrolase
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose." [EC:3.2.1.177]
synonym: "alpha-xylosidase" RELATED [EC:3.2.1.177]
xref: EC:3.2.1.177
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0061635
name: regulation of protein complex stability
namespace: biological_process
def: "Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly." [GOC:dph]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0061638
name: CENP-A containing chromatin
namespace: cellular_component
alt_id: GO:1904834
def: "The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment." [GOC:vw, PMID:20206496, PMID:22729156, PMID:24710126]
synonym: "centromeric core domain chromatin" RELATED [GOC:vw]
synonym: "centromeric core region chromatin" EXACT [GOC:vw]
synonym: "chromatin containing CENP-A" EXACT []
synonym: "nuclear CENP-A containing chromatin" NARROW []
is_a: GO:0000785 ! chromatin
relationship: part_of GO:0034506 ! chromosome, centromeric core domain

[Term]
id: GO:0061639
name: Cdv-dependent cytokinesis
namespace: biological_process
def: "A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells." [GOC:dph, PMID:18987308]
is_a: GO:0000910 ! cytokinesis

[Term]
id: GO:0061640
name: cytoskeleton-dependent cytokinesis
namespace: biological_process
def: "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]
is_a: GO:0000910 ! cytokinesis

[Term]
id: GO:0061642
name: chemoattraction of axon
namespace: biological_process
def: "The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:dph, GOC:krc]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0061643
name: chemorepulsion of axon
namespace: biological_process
def: "The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:dph, GOC:krc]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0061644
name: protein localization to CENP-A containing chromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin." [GOC:dph, GOC:vw]
is_a: GO:0071168 ! protein localization to chromatin
is_a: GO:0071459 ! protein localization to chromosome, centromeric region

[Term]
id: GO:0061645
name: endocytic patch
namespace: cellular_component
def: "The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle." [GOC:dph, PMID:22949647]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0061646
name: positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter." [GOC:pad, GOC:PARL]
is_a: GO:0051716 ! cellular response to stimulus
is_a: GO:1903296 ! positive regulation of glutamate secretion, neurotransmission

[Term]
id: GO:0061647
name: obsolete histone H3-K9 modification
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 at a lysine in position 9 of the histone." [GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061648
name: tooth replacement
namespace: biological_process
def: "The process whose specific outcome is the replacement of an existing tooth with another tooth." [GOC:dph, PMID:15170864]
is_a: GO:0042476 ! odontogenesis

[Term]
id: GO:0061649
name: ubiquitin-modified histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone that bears a ubiquinated lysine residue." [GOC:dph, PMID:24526689]
synonym: "ubiquitin modification-dependent histone binding" EXACT []
synonym: "ubiquitinated histone binding" RELATED []
is_a: GO:0140036 ! ubiquitin-modified protein reader activity
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:0061650
name: ubiquitin-like protein conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD []
synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0061651
name: Atg12 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0019777 ! Atg12 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0061652
name: FAT10 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0019775 ! FAT10 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0061653
name: ISG15 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0042296 ! ISG15 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0061654
name: NEDD8 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
xref: EC:2.3.2.34
is_a: GO:0019788 ! NEDD8 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0061655
name: Pup conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
is_a: GO:0072496 ! Pup transferase activity

[Term]
id: GO:0061656
name: SUMO conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0019789 ! SUMO transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0061657
name: UFM1 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
is_a: GO:0071568 ! UFM1 transferase activity

[Term]
id: GO:0061658
name: URM1 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0042294 ! URM1 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0061659
name: ubiquitin-like protein ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
synonym: "small conjugating protein ligase activity" EXACT [GOC:dph]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0061660
name: Atg12 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0019777 ! Atg12 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0061661
name: FAT10 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S = X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0019775 ! FAT10 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0061662
name: ISG15 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0042296 ! ISG15 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0061663
name: NEDD8 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0019788 ! NEDD8 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0061664
name: Pup ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S = X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
is_a: GO:0072496 ! Pup transferase activity

[Term]
id: GO:0061665
name: SUMO ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
xref: Reactome:R-HSA-9834809 "SUMOylation of PKR"
xref: Reactome:R-HSA-9842868 "TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2"
is_a: GO:0019789 ! SUMO transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0061666
name: UFM1 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
is_a: GO:0071568 ! UFM1 transferase activity

[Term]
id: GO:0061667
name: URM1 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S = X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0042294 ! URM1 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

[Term]
id: GO:0061668
name: mitochondrial ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph]
is_a: GO:0042255 ! ribosome assembly

[Term]
id: GO:0061669
name: spontaneous neurotransmitter secretion
namespace: biological_process
def: "Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]
synonym: "stimulus-independent neurotransmitter secretion" EXACT [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
relationship: part_of GO:0098814 ! spontaneous synaptic transmission

[Term]
id: GO:0061670
name: evoked neurotransmitter secretion
namespace: biological_process
def: "Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]
synonym: "stimulus-dependant neurotransmitter secretion" EXACT [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0061671
name: Cbp3p-Cbp6 complex
namespace: cellular_component
def: "A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly." [GOC:dph, GOC:rb, PMID:21670217]
is_a: GO:0098798 ! mitochondrial protein-containing complex

[Term]
id: GO:0061672
name: glutathione hydrolase complex
namespace: cellular_component
def: "Enzyme complex that in S. cerevisiae has components Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly." [GOC:dph]
synonym: "gamma-glutamyltranspeptidase complex" EXACT [GOC:dph]
synonym: "glutamine amidotransferase II complex" NARROW [PMID:22277648]
synonym: "glutathionase complex" EXACT [GOC:dph]
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:0061673
name: mitotic spindle astral microtubule
namespace: cellular_component
def: "Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph]
is_a: GO:0000235 ! astral microtubule
relationship: part_of GO:0072686 ! mitotic spindle

[Term]
id: GO:0061674
name: gap filling involved in double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining." [GOC:dph]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006303 ! double-strand break repair via nonhomologous end joining

[Term]
id: GO:0061675
name: RBL family protein binding
namespace: molecular_function
def: "Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose." [PMID:22312473]
synonym: "rhamnose-binding lectin family protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0061676
name: importin-alpha family protein binding
namespace: molecular_function
def: "Binding to a member of the importin-alpha family." [PMID:15350979, PMID:17170104, PMID:23734157]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0061677
name: 2-dehydro-3-deoxy-D-gluconate aldolase activity
namespace: molecular_function
alt_id: GO:0043725
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde." [GOC:dph, PMID:12824170, RHEA:35583]
synonym: "2-keto-3-deoxygluconate aldolase activity" EXACT []
synonym: "KDG aldolase activity" EXACT []
xref: EC:4.1.2.51
xref: MetaCyc:DHDOGALDOL-RXN
xref: RHEA:35583
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0061678
name: Entner-Doudoroff pathway
namespace: biological_process
def: "A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate." [GOC:dph, PMID:12921536]
xref: MetaCyc:Entner-Doudoroff-Pathways
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0061679
name: Entner-Doudoroff pathway through gluconate
namespace: biological_process
def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate." [GOC:dph, PMID:12921536]
synonym: "gluconate pathway" RELATED []
is_a: GO:0061678 ! Entner-Doudoroff pathway

[Term]
id: GO:0061680
name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde
namespace: biological_process
def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde." [GOC:dph, MetaCyc:NPGLUCAT-PWY, PMID:12921536]
xref: MetaCyc:NPGLUCAT-PWY
is_a: GO:0019595 ! non-phosphorylated glucose catabolic process
is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate
is_a: GO:0061718 ! glucose catabolic process to pyruvate

[Term]
id: GO:0061681
name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate
namespace: biological_process
def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate." [GOC:dph, PMID:12921536]
xref: MetaCyc:PWY-2221
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate

[Term]
id: GO:0061682
name: seminal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a seminal vesicle are generated and organized." [GOC:dph]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0061107 ! seminal vesicle development

[Term]
id: GO:0061683
name: branching involved in seminal vesicle morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph, PMID:16916376]
synonym: "gonecyst branching morphogenesis" EXACT [GOC:dph]
synonym: "seminal gland branching morphogenesis" EXACT [GOC:dph]
synonym: "seminal vesicle branching" EXACT [GOC:dph]
synonym: "seminal vesicle branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0061138 ! morphogenesis of a branching epithelium
relationship: part_of GO:0061108 ! seminal vesicle epithelium development
relationship: part_of GO:0061682 ! seminal vesicle morphogenesis

[Term]
id: GO:0061684
name: chaperone-mediated autophagy
namespace: biological_process
def: "The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded." [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281]
synonym: "CASA" BROAD [PMID:23434281]
synonym: "chaperone-assisted selective autophagy" EXACT [PMID:23434281]
synonym: "CMA" BROAD [PMID:22743996]
xref: Wikipedia:Chaperone-mediated_autophagy
is_a: GO:0006914 ! autophagy
is_a: GO:0030163 ! protein catabolic process

[Term]
id: GO:0061685
name: diphthine methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656]
xref: EC:3.1.1.97
xref: RHEA:42656
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0061686
name: hercynylcysteine sulfoxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 = hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:24828577, PMID:4276459, RHEA:42704]
synonym: "hercynylcysteine S-oxide synthase" EXACT [GOC:dph]
synonym: "hercynylcysteine sulfoxide synthase" EXACT []
xref: EC:1.21.3.10
xref: RHEA:42704
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0061687
name: detoxification of inorganic compound
namespace: biological_process
def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw]
is_a: GO:0098754 ! detoxification

[Term]
id: GO:0061688
name: glycolytic process via Entner-Doudoroff Pathway
namespace: biological_process
def: "A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes." [GOC:dph, PMID:9657988]
synonym: "gluconate pathway" RELATED []
is_a: GO:0006096 ! glycolytic process

[Term]
id: GO:0061689
name: tricellular tight junction
namespace: cellular_component
def: "An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet." [GOC:dk, GOC:dph, PMID:22520461, PMID:25822906]
is_a: GO:0070160 ! tight junction

[Term]
id: GO:0061690
name: lipoamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] = (R)-lipoate + L-lysyl-[lipoyl-carrier protein]." [PMID:14086741, RHEA:76519]
synonym: "lipoyl-X-hydrolase" EXACT [PMID:14086741]
xref: EC:3.5.1.138
xref: MetaCyc:RXN-13031
xref: Reactome:R-HSA-9861626 "SIRT4 cleaves lipoyl from DLAT"
xref: RHEA:76519
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0061691
name: detoxification of hydrogen peroxide
namespace: biological_process
def: "Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph]
is_a: GO:0042743 ! hydrogen peroxide metabolic process
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0042542 ! response to hydrogen peroxide

[Term]
id: GO:0061692
name: cellular detoxification of hydrogen peroxide
namespace: biological_process
def: "Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph, GOC:vw]
is_a: GO:0061691 ! detoxification of hydrogen peroxide
is_a: GO:0098869 ! cellular oxidant detoxification
relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide

[Term]
id: GO:0061693
name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine." [EC:2.7.8.37, GOC:dph, PMID:22089136]
xref: EC:2.7.8.37
xref: MetaCyc:RXN0-6732
xref: RHEA:34679
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0061694
name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex
namespace: cellular_component
def: "A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity." [GOC:dph, PMID:22089136]
comment: An example of this complex is PhnI (P16687) in Escherichia coli.
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0061695
name: transferase complex, transferring phosphorus-containing groups
namespace: cellular_component
def: "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0061696
name: pituitary gonadotropin complex
namespace: cellular_component
def: "A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function." [GOC:dph, PMID:11420129]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0061697
name: protein-glutaryllysine deglutarylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD+ = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:dph, PMID:24703693]
comment: This reaction is the removal of a glutaryl group from a glutarylated lysine residue of a protein or peptide.
xref: RHEA:47664
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0061698
name: protein deglutarylation
namespace: biological_process
def: "The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein." [GOC:dph, PMID:24703693]
subset: gocheck_obsoletion_candidate
is_a: GO:0035601 ! protein deacylation

[Term]
id: GO:0061699
name: obsolete peptidyl-lysine deglutarylation
namespace: biological_process
def: "OBSOLETE. The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein." [GOC:dph, PMID:24703693]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061700
name: GATOR2 complex
namespace: cellular_component
def: "A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins." [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]
comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
synonym: "SEACAT complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0035859 ! Seh1-associated complex

[Term]
id: GO:0061701
name: bacterial outer membrane vesicle
namespace: cellular_component
def: "A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes." [GOC:dph, GOC:pr, PMID:20596524]
is_a: GO:1903561 ! extracellular vesicle

[Term]
id: GO:0061702
name: canonical inflammasome complex
namespace: cellular_component
def: "A cytosolic protein complex that is capable of activating caspase-1." [GOC:dph, PMID:17599095]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0061703
name: pyroptosome complex
namespace: cellular_component
def: "A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis." [GOC:dph, PMID:17599095]
synonym: "ASC pyroptosome" EXACT [PMID:17599095]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0061704
name: glycolytic process from sucrose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, PMID:15012287]
is_a: GO:0005987 ! sucrose catabolic process
is_a: GO:0006096 ! glycolytic process

[Term]
id: GO:0061705
name: sucrose catabolic process to fructose-6-phosphate through glucose and fructose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-621, PMID:15012287]
xref: MetaCyc:PWY-621
is_a: GO:0005987 ! sucrose catabolic process

[Term]
id: GO:0061706
name: glycolytic process from sucrose through glucose and fructose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-1042, PMID:15012287]
xref: MetaCyc:PWY-1042
is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate
is_a: GO:0061704 ! glycolytic process from sucrose

[Term]
id: GO:0061707
name: extracellular exosome macropinocytosis
namespace: biological_process
def: "The single-organism macropinocytosis process that results in the uptake of an extracellular exosome." [GOC:dph, PMID:24951588]
is_a: GO:0044351 ! macropinocytosis
is_a: GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:0061708
name: tRNA-5-taurinomethyluridine 2-sulfurtransferase
namespace: molecular_function
def: "Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [GOC:dph, PMID:15509579, RHEA:47040]
xref: EC:2.8.1.14
xref: MetaCyc:RXN-16821
xref: Reactome:R-HSA-6787447 "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA"
xref: RHEA:47040
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0061709
name: reticulophagy
namespace: biological_process
alt_id: GO:1990766
def: "The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]
synonym: "autophagy of the endoplasmic reticulum" EXACT []
synonym: "autophagy of the ER" EXACT []
synonym: "endoplasmic reticulum autophagy" EXACT []
synonym: "endoplasmic reticulum degradation" RELATED []
synonym: "ER autophagy" EXACT []
synonym: "ER degradation" RELATED []
synonym: "ER-phagy" EXACT []
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0061710
name: L-threonylcarbamoyladenylate synthase
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O." [EC:2.7.7.87]
xref: EC:2.7.7.87
xref: MetaCyc:RXN-14569
xref: RHEA:36407
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0061711
name: N(6)-L-threonylcarbamoyladenine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA." [EC:2.3.1.234]
xref: EC:2.3.1.234
xref: MetaCyc:RXN-14570
xref: Reactome:R-HSA-6784494 "EKC complex threonylcarbamoylates A37 of tRNAs"
xref: RHEA:37059
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0061712
name: tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine." [EC:2.8.4.5]
xref: EC:2.8.4.5
xref: MetaCyc:RXN-14531
xref: RHEA:37075
is_a: GO:0035596 ! methylthiotransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0061713
name: anterior neural tube closure
namespace: biological_process
def: "The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline." [GOC:BHF, GOC:dph, GOC:hal, PMID:17286298]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0061714
name: folic acid receptor activity
namespace: molecular_function
def: "Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis." [GOC:BHF, GOC:hal]
synonym: "folate receptor activity" EXACT []
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0061715
name: obsolete miRNA 2'-O-methylation
namespace: biological_process
def: "OBSOLETE. The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20705645]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0090486

[Term]
id: GO:0061716
name: miRNA export from nucleus
namespace: biological_process
def: "The directed movement of a processed miRNA from the nucleus to the cytoplasm." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15738428, PMID:21554756]
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:1990428 ! miRNA transport

[Term]
id: GO:0061718
name: glucose catabolic process to pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate." [GOC:dph]
synonym: "glucose catabolism to pyruvate" EXACT [GOC:dph]
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006090 ! pyruvate metabolic process

[Term]
id: GO:0061719
name: glucose catabolic process to pyruvate utilizing ADP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions." [GOC:dph, MetaCyc:P341-PWY]
xref: MetaCyc:P341-PWY
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0061718 ! glucose catabolic process to pyruvate

[Term]
id: GO:0061720
name: 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA)." [GOC:dph, PMID:24463506]
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process
is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process

[Term]
id: GO:0061721
name: 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-)
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-)." [GOC:dph, PMID:14602517, PMID:24463506]
xref: MetaCyc:PWY-7446
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0051143 ! propanediol metabolic process
is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process

[Term]
id: GO:0061722
name: sulphoglycolysis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate." [GOC:dph, PMID:24463506]
synonym: "sulfoglycolysis" EXACT [PMID:14602597]
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0006734 ! NADH metabolic process
is_a: GO:0046034 ! ATP metabolic process
is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process

[Term]
id: GO:0061723
name: glycophagy
namespace: biological_process
def: "The selective degradation of glycogen by macroautophagy." [GOC:autophagy, PMID:21893048]
is_a: GO:0005980 ! glycogen catabolic process
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0061724
name: lipophagy
namespace: biological_process
def: "The selective degradation of lipid droplets by macroautophagy." [GOC:autophagy, PMID:23708524, PMID:26076903]
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0061725
name: cytosolic lipolysis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy]
is_a: GO:0016042 ! lipid catabolic process

[Term]
id: GO:0061726
name: obsolete mitochondrion disassembly
namespace: biological_process
def: "OBSOLETE. The disaggregation of a mitochondrion into its constituent components." [GOC:autophagy, PMID:25009776]
comment: This term is obsoleted because it was an unnecessary grouping class
synonym: "mitochondrion degradation" EXACT [GOC:autophagy]
is_obsolete: true
replaced_by: GO:0000422

[Term]
id: GO:0061727
name: methylglyoxal catabolic process to lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate." [GOC:dph, PMID:2198020]
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0051596 ! methylglyoxal catabolic process

[Term]
id: GO:0061728
name: GDP-mannose biosynthetic process from mannose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose." [GOC:dph, PMID:16339137, PMID:24218558]
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0009298 ! GDP-mannose biosynthetic process

[Term]
id: GO:0061729
name: GDP-mannose biosynthetic process from fructose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate." [GOC:dph, PMID:16339137]
is_a: GO:0009298 ! GDP-mannose biosynthetic process

[Term]
id: GO:0061730
name: C-rich strand telomeric DNA binding
namespace: molecular_function
def: "Binding to C-rich, single-stranded, telomere-associated DNA." [GOC:dph, GOC:kmv, PMID:18329362]
is_a: GO:0043047 ! single-stranded telomeric DNA binding

[Term]
id: GO:0061731
name: ribonucleoside-diphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [GOC:dph, GOC:vw, PMID:16756507]
synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED []
synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED []
synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED []
synonym: "class I ribonucleotide reductase activity" RELATED []
synonym: "class II ribonucleoside-diphosphate reductase activity" RELATED []
synonym: "class II ribonucleotide reductase activity" RELATED []
synonym: "class III ribonucleotide reductase activity" RELATED []
synonym: "nucleoside diphosphate reductase activity" RELATED []
synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED []
synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT []
synonym: "ribonucleotide diphosphate reductase activity" EXACT []
synonym: "ribonucleotide reductase activity" BROAD []
synonym: "RNR" RELATED []
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0061732
name: obsolete mitochondrial acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA." [GOC:dph, ISBN:0201090910]
comment: This term was obsoleted because it was representing the same process as its parent.
is_obsolete: true
replaced_by: GO:0006086

[Term]
id: GO:0061733
name: peptide-lysine-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide." [GOC:dph, RHEA:45948]
synonym: "peptide-lysine-N-acetylase activity" EXACT []
synonym: "protein acetylase activity" BROAD []
synonym: "protein acetyltransferase activity" BROAD []
synonym: "protein-lysine-N-acetylase activity" EXACT []
xref: Reactome:R-HSA-6811508 "ING2-bound EP300 acetylates TP53"
xref: Reactome:R-HSA-8951966 "EP300 acetylates RUNX3"
xref: Reactome:R-HSA-9617758 "EP300,CREBBP acetylate FOXO4"
xref: Reactome:R-HSA-9620515 "KAT2B,EP300 acetylate FOXO3 under oxidative stress"
xref: Reactome:R-HSA-9626945 "CREBBP acetylates FOXO1"
xref: Reactome:R-HSA-9701531 "p-Y705,S727 STAT3 is acetylated"
xref: Reactome:R-HSA-9756494 "CREBBP acetylates SARS-CoV-2 N at K375"
xref: Reactome:R-HSA-9825747 "CREBBP acetylates HINT1 dimer"
xref: RHEA:45948
is_a: GO:0034212 ! peptide N-acetyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0061734
name: type 2 mitophagy
namespace: biological_process
def: "The selective autophagy process in which a mitochondrion is degraded by macroautophagy in a process initiated by mitochondrial depolarization (mtDepo) followed by Parkin binding, and ubiquitination of outer membrane proteins, to remove potentially harm-inducing dysfunctional/damaged mitochondria." [GOC:vw, PMID:25009776, PMID:25349190]
synonym: "Park2-mediated mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "PRKN-mediated mitophagy in response to mitochondrial depolarization" EXACT []
is_a: GO:0000423 ! mitophagy

[Term]
id: GO:0061735
name: obsolete DNM1L-mediated stimulation of mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "OBSOLETE. A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a DNM1L-family molecule." [PMID:25349190]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
synonym: "dynamin-like protein-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
is_obsolete: true
replaced_by: GO:1905091

[Term]
id: GO:0061736
name: engulfment of target by autophagosome
namespace: biological_process
def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL]
is_a: GO:0010324 ! membrane invagination
relationship: part_of GO:0000045 ! autophagosome assembly

[Term]
id: GO:0061737
name: leukotriene signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:dph, PMID:21771892]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0061738
name: late endosomal microautophagy
namespace: biological_process
def: "The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:21238931]
is_a: GO:0016237 ! microautophagy

[Term]
id: GO:0061739
name: protein lipidation involved in autophagosome assembly
namespace: biological_process
def: "The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly." [GOC:autophagy, GOC:dph, PMID:11096062, PMID:11100732, PMID:15277523]
subset: gocheck_obsoletion_candidate
is_a: GO:0006501 ! C-terminal protein lipidation
relationship: part_of GO:0000045 ! autophagosome assembly

[Term]
id: GO:0061740
name: protein targeting to lysosome involved in chaperone-mediated autophagy
namespace: biological_process
def: "The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor." [GOC:dph, GOC:pad, GOC:PARL, PMID:22748206]
is_a: GO:0006622 ! protein targeting to lysosome
is_a: GO:0071211 ! protein targeting to vacuole involved in autophagy
relationship: part_of GO:0061684 ! chaperone-mediated autophagy

[Term]
id: GO:0061741
name: obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy
namespace: biological_process
def: "OBSOLETE. The chaperone-mediated protein transport process in which a protein that is bound to a chaperone and a lysosomal receptor is unfolded and transported into the lysosome as part of chaperone-mediated autophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:22748206]
comment: This term was obsoleted because it represents a function within a process.
is_obsolete: true

[Term]
id: GO:0061742
name: chaperone-mediated autophagy translocation complex
namespace: cellular_component
def: "A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy." [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626]
synonym: "chaperone-mediated autophagy receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL]
synonym: "CMA receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL]
synonym: "CMA translocation complex" EXACT [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0061743
name: motor learning
namespace: biological_process
def: "Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience." [GOC:bf, GOC:PARL, Wikipedia:Motor_learning]
is_a: GO:0007612 ! learning

[Term]
id: GO:0061744
name: motor behavior
namespace: biological_process
def: "The specific neuromuscular movement of a single organism in response to external or internal stimuli." [GOC:bf, GOC:PARL, PMID:25318560]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0061746
name: obsolete single-stranded DNA-dependent GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:dph, PMID:26277776]
comment: This term was obsoleted because there is no evidence that this reaction occurs under physiological conditions.
is_obsolete: true

[Term]
id: GO:0061749
name: forked DNA-dependent helicase activity
namespace: molecular_function
def: "Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis." [GOC:dph, PMID:26277776]
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0061750
name: acid sphingomyelin phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment." [GOC:dph, PMID:26493087]
synonym: "acid SMase" RELATED [PMID:26493087]
synonym: "acid sphingomyelinase" EXACT [PMID:26493087]
is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity

[Term]
id: GO:0061751
name: neutral sphingomyelin phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment." [GOC:dph, PMID:26493087]
synonym: "neutral SMase" EXACT [PMID:26493087]
synonym: "neutral sphingomyelinase" EXACT [GOC:26493087]
is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity

[Term]
id: GO:0061752
name: telomeric repeat-containing RNA binding
namespace: molecular_function
def: "Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats." [GOC:BHF, GOC:BHF_telomere, GOC:dph, GOC:jbu, PMID:20655916]
synonym: "TERRA binding" EXACT [PMID:20655916]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0061753
name: substrate localization to autophagosome
namespace: biological_process
def: "The localization process by which an autophagic substrate is delivered to a forming autophagosome." [GOC:dph, GOC:pad, GOC:PARL, PMID:23545414]
synonym: "substrate sequestration to autophagosome" EXACT []
synonym: "substrate sequestration to phagophore" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
relationship: part_of GO:0000045 ! autophagosome assembly

[Term]
id: GO:0061754
name: negative regulation of circulating fibrinogen levels
namespace: biological_process
def: "Any process that reduces the quantity of fibrinogen circulating in the bloodstream." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20570858]
is_a: GO:0044537 ! regulation of circulating fibrinogen levels

[Term]
id: GO:0061755
name: positive regulation of circulating fibrinogen levels
namespace: biological_process
def: "Any process that increases the quantity of fibrinogen circulating in the bloodstream." [GOC:bf, GOC:BHF, GOC:BHF_miRNA, PMID:20570858]
is_a: GO:0044537 ! regulation of circulating fibrinogen levels

[Term]
id: GO:0061756
name: leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "The attachment of a leukocyte to vascular endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:23897866]
is_a: GO:0007159 ! leukocyte cell-cell adhesion

[Term]
id: GO:0061757
name: leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22267480]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell

[Term]
id: GO:0061758
name: 2-hydroxyglutarate dehydrogenase activity, forward reaction
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor." [GOC:dph, RHEA:21253]
synonym: "alpha-ketoglutarate reductase activity, reverse reaction" EXACT [GOC:dph]
xref: RHEA:21253
is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity

[Term]
id: GO:0061759
name: alpha-ketoglutarate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor." [GOC:dph, PMID:26774271, RHEA:21254]
synonym: "2-hydroxyglutarate dehydrogenase activity, reverse reaction" EXACT [GOC:dph]
synonym: "2-ketoglutarate reductase activity" RELATED [GOC:dph]
synonym: "2-oxoglutarate reductase activity" RELATED [GOC:dph]
synonym: "D-2HG reductase activity" RELATED [GOC:dph]
xref: RHEA:21254
is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity

[Term]
id: GO:0061760
name: antifungal innate immune response
namespace: biological_process
def: "An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:dph, PMID:22470487]
is_a: GO:0045087 ! innate immune response
is_a: GO:0050832 ! defense response to fungus

[Term]
id: GO:0061761
name: alpha-latrotoxin receptor binding
namespace: molecular_function
def: "Binding to an alpha-latrotoxin receptor." [GOC:dph, PMID:21724987]
synonym: "lasso receptor binding" EXACT [GOC:dph, PMID:21724987]
synonym: "latrophilin binding" EXACT [GOC:dph, PMID:21724987]
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0061762
name: CAMKK-AMPK signaling cascade
namespace: biological_process
def: "The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity." [GOC:dph, GOC:pad, GOC:PARL, PMID:23010169, PMID:24709372]
synonym: "stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:dph]
is_a: GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0061763
name: multivesicular body-lysosome fusion
namespace: biological_process
def: "The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle." [GOC:dph, GOC:pad, GOC:PARL, PMID:21118109]
synonym: "endosome-lysosome fusion" RELATED []
synonym: "fusion of multivesicular body to lysosome" EXACT [GOC:dph]
synonym: "fusion of MVB to lysosome" EXACT [GOC:dph]
synonym: "late endosome-lysosome fusion" RELATED []
synonym: "MVB-lysosome fusion" EXACT [GOC:dph]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0097212 ! lysosomal membrane organization
relationship: part_of GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway

[Term]
id: GO:0061764
name: late endosome to lysosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:dph]
is_a: GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway
is_a: GO:0045324 ! late endosome to vacuole transport
is_a: GO:1902774 ! late endosome to lysosome transport

[Term]
id: GO:0061765
name: obsolete perturbation by virus of host non-canonical NF-kappaB signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont alters or subverts a non-canonical NF-kappaB signaling cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:26764146]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host NF-kappaB cascade ; GO:0085032.
synonym: "modulation by virus of host NIK/NF-kappaB cascade" EXACT []
synonym: "modulation by virus of host NIK/NF-kappaB signaling" EXACT []
synonym: "perturbation by virus of host NIK/NF-kappaB cascade" EXACT []
is_obsolete: true
replaced_by: GO:0085034

[Term]
id: GO:0061766
name: positive regulation of lung blood pressure
namespace: biological_process
def: "The process that increases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22161164]
synonym: "positive regulation of pulmonary blood pressure" EXACT [GOC:dph]
is_a: GO:0014916 ! regulation of lung blood pressure

[Term]
id: GO:0061767
name: negative regulation of lung blood pressure
namespace: biological_process
def: "The process that decreases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:dph, PMID:22161164]
synonym: "negative regulation of pulmonary blood pressure" EXACT [GOC:dph]
is_a: GO:0014916 ! regulation of lung blood pressure

[Term]
id: GO:0061768
name: magnesium:sodium antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in)." [GOC:pad, GOC:PARL, PMID:22031603]
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015095 ! magnesium ion transmembrane transporter activity
is_a: GO:0140828 ! metal cation:monoatomic cation antiporter activity

[Term]
id: GO:0061769
name: ribosylnicotinate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide." [GOC:dph, PMID:17914902]
xref: Reactome:R-HSA-8869606 "NMRK1 phosphorylates NAR to yield NAMN"
xref: Reactome:R-HSA-8869607 "NMRK2 phosphorylates NAR to yield NAMN"
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0061770
name: translation elongation factor binding
namespace: molecular_function
def: "Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation." [GOC:dph]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0061771
name: response to caloric restriction
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake." [GOC:dph, PMID:15520862]
is_a: GO:0006950 ! response to stress
is_a: GO:0031667 ! response to nutrient levels

[Term]
id: GO:0061772
name: xenobiotic transport across blood-nerve barrier
namespace: biological_process
def: "The directed movement of a xenobiotic through the blood-nerve barrier." [GOC:dph, PMID:22733753]
synonym: "drug transport across blood-nerve barrier" RELATED []
synonym: "drug transport across perineurial barrier" EXACT [PMID:22733753]
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0061773
name: eNoSc complex
namespace: cellular_component
def: "A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation." [GOC:BHM, Intact:EBI-11789632, Intact:EBI-11790279, PMID:18485871]
synonym: "energy dependent nucleolar silencing complex" EXACT []
is_a: GO:0005677 ! chromatin silencing complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0061774
name: obsolete cohesin unloading
namespace: biological_process
def: "OBSOLETE. Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA." [GOC:dph, GOC:vw, PMID:26687354]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "DNA exit from the cohesin ring" EXACT [GOC:dph, GOC:vw]
is_obsolete: true

[Term]
id: GO:0061775
name: cohesin loader activity
namespace: molecular_function
def: "Facilitating a conformational change to load a cohesin complex around sister chromatids." [GOC:vw, PMID:26687354]
synonym: "cohesin loading activity" EXACT []
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0061776
name: ATP-dependent topological DNA co-entrapment activity
namespace: molecular_function
def: "A DNA binding activity in which a protein complex interacts with at least one DNA duplex to encircle the DNA molecules with a loose fitting ring." [GOC:dph, GOC:vw, PMID:16179255, PMID:26687354, PMID:27797071, PMID:29358048, PMID:37820734]
synonym: "ATP-dependent ring closure activity" EXACT []
synonym: "topological DNA entrapment activity" RELATED []
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0061777
name: obsolete DNA clamp activity
namespace: molecular_function
def: "OBSOLETE. A DNA binding activity in which a protein complex interacts selectively and non-covalently with single DNA duplex to tightly encircle the DNA." [GOC:dph, GOC:vw, PMID:1349852]
comment: The reason for obsoletion is that the term captures the structure of a complex, not a specific function.
is_obsolete: true

[Term]
id: GO:0061778
name: obsolete intracellular chloride channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:dph, PMID:23092411]
comment: The reason for obsoletion is that this term represents a mix of a MF + a CC.
is_obsolete: true
replaced_by: GO:0005254

[Term]
id: GO:0061779
name: Tapasin-ERp57 complex
namespace: cellular_component
def: "Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role." [GOC:bhm, GOC:dph, Intact:EBI-11896237, Intact:EBI-9013963, PMID:17603487]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0042824 ! MHC class I peptide loading complex

[Term]
id: GO:0061780
name: obsolete mitotic cohesin loading
namespace: biological_process
def: "OBSOLETE. The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle." [GOC:dph, GOC:vw]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061781
name: obsolete mitotic cohesin unloading
namespace: biological_process
def: "OBSOLETE. Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA as part of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:vw]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061782
name: vesicle fusion with vesicle
namespace: biological_process
def: "Fusion of the membrane of a transport vesicle with a target membrane on another vesicle." [GOC:bf, GOC:PARL, PMID:16618809]
synonym: "vesicle to vesicle fusion" EXACT [GOC:dph]
synonym: "vesicle-vesicle fusion" EXACT [GOC:dph]
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:0061783
name: peptidoglycan muralytic activity
namespace: molecular_function
def: "A catalytic activity that contributes to the degradation of peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0061784
name: peptidoglycan N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813]
is_a: GO:0015929 ! hexosaminidase activity
is_a: GO:0061783 ! peptidoglycan muralytic activity

[Term]
id: GO:0061785
name: peptidoglycan endopeptidase activity
namespace: molecular_function
def: "An endopeptidase activity that uses peptidoglycan as a substrate." [GOC:dph, GOC:jh, PMID:22748813]
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0061783 ! peptidoglycan muralytic activity

[Term]
id: GO:0061786
name: peptidoglycan stem peptide endopeptidase activity
namespace: molecular_function
def: "A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813]
is_a: GO:0061785 ! peptidoglycan endopeptidase activity

[Term]
id: GO:0061787
name: peptidoglycan cross-bridge peptide endopeptidase activity
namespace: molecular_function
def: "A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge." [GOC:dph, GOC:jh, PMID:22748813]
synonym: "lysostaphin activity" NARROW [GOC:dph, GOC:jh, PMID:22748813]
is_a: GO:0061785 ! peptidoglycan endopeptidase activity

[Term]
id: GO:0061788
name: EGF repeat binding
namespace: molecular_function
def: "Binding to Epidermal Growth Factor (EGF) repeats." [GOC:25700513, GOC:dph, PMID:25155514]
synonym: "Epidermal growth factor domain binding" BROAD [GOC:dph]
synonym: "Epidermal Growth Factor repeat binding" RELATED [GOC:dph]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0061789
name: dense core granule priming
namespace: biological_process
def: "A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking." [GOC:bf, GOC:PARL, PMID:10899113, PMID:26575293]
synonym: "dense core vesicle priming" EXACT [PMID:26575293]
synonym: "large dense-core vesicle priming" EXACT [PMID:10899113]
synonym: "LDCV priming" EXACT [PMID:26575293]
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:1990504 ! dense core granule exocytosis

[Term]
id: GO:0061790
name: dense core granule docking
namespace: biological_process
def: "The initial attachment of a dense core granule membrane to the plasma membrane." [GOC:bf, GOC:PARL, PMID:26575293]
is_a: GO:0006904 ! vesicle docking involved in exocytosis
relationship: part_of GO:1990504 ! dense core granule exocytosis

[Term]
id: GO:0061791
name: GTPase motor activity
namespace: molecular_function
def: "A motor activity driven by GTP hydrolysis." [GOC:dph, GOC:vw, PMID:11242086]
is_a: GO:0003774 ! cytoskeletal motor activity
is_a: GO:0003924 ! GTPase activity

[Term]
id: GO:0061792
name: secretory granule maturation
namespace: biological_process
def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809]
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0071695 ! anatomical structure maturation

[Term]
id: GO:0061793
name: chromatin lock complex
namespace: cellular_component
def: "A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping." [GOC:bhm, GOC:dph, PMID:17540172]
synonym: "nucleosome bridging complex" RELATED [GOC:dph]
is_a: GO:0005677 ! chromatin silencing complex

[Term]
id: GO:0061794
name: conidium development
namespace: biological_process
def: "The process whose specific outcome is the progression of conidium over time, from its formation to the mature structure. Conidia are non-motile spores produced via mitotic asexual reproduction in higher fungi; they are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:dph]
is_a: GO:0048468 ! cell development

[Term]
id: GO:0061795
name: Golgi lumen acidification
namespace: biological_process
def: "Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion." [GOC:dph, PMID:23447592]
synonym: "Golgi apparatus lumen acidification" EXACT []
is_a: GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0061796
name: membrane addition at site of mitotic cytokinesis
namespace: biological_process
def: "A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:dph, GOC:vw]
is_a: GO:0007107 ! membrane addition at site of cytokinesis
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:0061797
name: pH-gated chloride channel activity
namespace: molecular_function
def: "A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH." [GOC:dph, PMID:27358471]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity
is_a: GO:0160128 ! pH-gated monoatomic ion channel activity

[Term]
id: GO:0061798
name: GTP 3',8'-cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate." [GOC:dph, GOC:ik, PMID:25896388]
xref: EC:4.1.99.22
xref: MetaCyc:RXN-8340
xref: RHEA:49576
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0061799
name: cyclic pyranopterin monophosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388]
xref: EC:4.6.1.17
xref: MetaCyc:RXN-17809
xref: RHEA:49580
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0061800
name: fibronectin fibril
namespace: cellular_component
def: "A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks." [GOC:dph, PMID:20690820]
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0061801
name: laminin-5B complex
namespace: cellular_component
def: "A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains." [GOC:dph, PMID:15979864]
synonym: "laminin 3B32 complex" EXACT [PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0061802
name: anterior cell cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis." [GOC:15666355, GOC:17981131, GOC:dph, GOC:kmv]
is_a: GO:0099738 ! cell cortex region

[Term]
id: GO:0061803
name: posterior cell cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis." [GOC:dph, GOC:kmv, PMID:15666355, PMID:17981131]
is_a: GO:0099738 ! cell cortex region

[Term]
id: GO:0061804
name: mitotic spindle formation (spindle phase one)
namespace: biological_process
def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase." [GOC:dph, GOC:vw, PMID:21920317]
synonym: "mitotic spindle elongation during mitotic prophase" EXACT []
synonym: "mitotic spindle elongation during prophase" EXACT []
synonym: "mitotic spindle elongation during prophase and prometaphase" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
relationship: part_of GO:0000022 ! mitotic spindle elongation
relationship: part_of GO:0090307 ! mitotic spindle assembly

[Term]
id: GO:0061805
name: mitotic spindle elongation (spindle phase three)
namespace: biological_process
def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B." [GOC:dph, GOC:vw, PMID:21920317]
synonym: "mitotic anaphase spindle elongation" EXACT []
synonym: "mitotic spindle elongation during anaphase" EXACT []
synonym: "mitotic spindle elongation during mitotic anaphase" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
relationship: part_of GO:0000022 ! mitotic spindle elongation

[Term]
id: GO:0061806
name: regulation of DNA recombination at centromere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA." [GOC:dph, GOC:mah, PMID:27697832]
synonym: "regulation of centromeric recombination" EXACT [GOC:mah]
is_a: GO:0000018 ! regulation of DNA recombination

[Term]
id: GO:0061807
name: positive regulation of DNA recombination at centromere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere." [GOC:dph, GOC:mah]
synonym: "positive regulation of centromeric recombination" EXACT [GOC:mah]
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0061806 ! regulation of DNA recombination at centromere

[Term]
id: GO:0061808
name: negative regulation of DNA recombination at centromere
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere." [GOC:dph, GOC:mah]
synonym: "negative regulation of centromeric recombination" EXACT [GOC:dph]
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0061806 ! regulation of DNA recombination at centromere

[Term]
id: GO:0061809
name: NAD+ nucleotidase, cyclic ADP-ribose generating
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose, in a two steps reaction: first an ADP-ribosyl cyclase reaction, followed by a cyclic ADP-ribose hydrolase reaction." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528]
synonym: "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase" EXACT []
synonym: "NAD hydrolase" NARROW []
synonym: "NAD(+) nucleosidase" NARROW []
synonym: "NADase" NARROW []
synonym: "nicotinamide adenine dinucleotide nucleosidase" NARROW []
xref: EC:3.2.2.6
xref: MetaCyc:NADNUCLEOSID-RXN
xref: Reactome:R-HSA-8870346 "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose"
xref: Reactome:R-HSA-8938076 "CD38 hydrolyses NAD+ to NAM and ADP-ribose"
xref: Reactome:R-HSA-9637699 "CpnT hydrolyses NAD+"
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0061810
name: obsolete NAD glycohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528]
comment: This term was obsoleted because it represents the same activity as NAD(P)+ nucleosidase activity ; GO:0050135.
is_obsolete: true
replaced_by: GO:0050135

[Term]
id: GO:0061811
name: obsolete ADP-ribosyl cyclase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide." [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528]
comment: This term was obsoleted because it represents a step in a multi-step reaction.
is_obsolete: true
replaced_by: GO:0061809

[Term]
id: GO:0061812
name: obsolete cyclic ADP-ribose hydrolase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR)." [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528]
comment: This term was obsoleted because it represents a step in a multi-step reaction.
is_obsolete: true
replaced_by: GO:0061809

[Term]
id: GO:0061813
name: obsolete ARID domain binding
namespace: molecular_function
def: "OBSOLETE. Binding to a ARID domain. The AT-rich interaction domain (ARID) is an ~100-amino acid DNA-binding module found in a large number of eukaryotic transcription factors." [GOC:dph, InterPro:IPR001606, PMID:18270511]
is_obsolete: true

[Term]
id: GO:0061815
name: Met1-linked polyubiquitin deubiquitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains." [GOC:dph, PMID:26503766, PMID:27702987]
synonym: "cysteine-type deubiquitinase activity, acting on linear ubiquitin" EXACT []
synonym: "deubiquitinase, acting on linear ubiquitin" BROAD []
synonym: "linear ubiquitin specific deubiquitinase activity" EXACT []
synonym: "Met1 linkage specific DUB" EXACT []
synonym: "ubiquitinyl hydrolase activity, acting on linear ubiquitin" EXACT []
xref: Reactome:R-HSA-9818975 "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex"
is_a: GO:0004843 ! cysteine-type deubiquitinase activity

[Term]
id: GO:0061816
name: proteaphagy
namespace: biological_process
def: "The selective degradation of proteasomes by macroautophagy." [GOC:dph, GOC:se, PMID:26670610, PMID:27477278]
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0061817
name: endoplasmic reticulum-plasma membrane tethering
namespace: biological_process
def: "The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]
synonym: "ER-plasma membrane tethering" EXACT [GOC:dph]
is_a: GO:0051643 ! endoplasmic reticulum localization
is_a: GO:0140056 ! organelle localization by membrane tethering

[Term]
id: GO:0061818
name: tRNA folding
namespace: biological_process
def: "The process of assisting in the folding of tRNAs into the correct tertiary structure." [GOC:dph, PMID:27849601]
is_a: GO:0034337 ! RNA folding

[Term]
id: GO:0061819
name: telomeric DNA-containing double minutes formation
namespace: biological_process
def: "A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:14690602, PMID:2397458]
synonym: "TDMs formation" EXACT []
is_a: GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0061820
name: telomeric D-loop disassembly
namespace: biological_process
def: "A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:10338204, PMID:24012755]
is_a: GO:0090657 ! telomeric loop disassembly

[Term]
id: GO:0061821
name: telomeric D-loop binding
namespace: molecular_function
def: "Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19734539]
synonym: "telomeric Displacement-loop binding" EXACT []
is_a: GO:0062037 ! D-loop DNA binding

[Term]
id: GO:0061822
name: ciliary cap
namespace: cellular_component
def: "An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole." [PMID:25447994, PMID:27646273]
synonym: "spermatid ciliary cap" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0061823
name: ring centriole
namespace: cellular_component
def: "A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum." [PMID:25447994, PMID:4903810]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0061824
name: cytosolic ciliogenesis
namespace: biological_process
def: "The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm." [PMID:25447994, PMID:26654377]
synonym: "intracellular ciliogenesis" RELATED []
is_a: GO:0060271 ! cilium assembly

[Term]
id: GO:0061825
name: podosome core
namespace: cellular_component
def: "The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [PMID:23158496]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0002102 ! podosome

[Term]
id: GO:0061826
name: podosome ring
namespace: cellular_component
def: "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin." [PMID:23158496]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0002102 ! podosome

[Term]
id: GO:0061827
name: sperm head
namespace: cellular_component
def: "The part of the late spermatid or spermatozoon that contains the nucleus and acrosome." [PMID:22797892, PMID:24665388]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0061828
name: apical tubulobulbar complex
namespace: cellular_component
def: "Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell." [PMID:20403871, PMID:22510523]
synonym: "apical TBC" EXACT []
is_a: GO:0036284 ! tubulobulbar complex

[Term]
id: GO:0061829
name: basal tubulobulbar complex
namespace: cellular_component
def: "Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell." [PMID:20403871, PMID:22510523]
synonym: "basal TBC" EXACT []
is_a: GO:0036284 ! tubulobulbar complex

[Term]
id: GO:0061830
name: concave side of sperm head
namespace: cellular_component
def: "The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species." [PMID:22332112, PMID:23403943, PMID:26990065]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0061827 ! sperm head

[Term]
id: GO:0061831
name: apical ectoplasmic specialization
namespace: cellular_component
def: "Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell." [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604]
synonym: "apical ES" EXACT []
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0061832
name: basal ectoplasmic specialization
namespace: cellular_component
def: "Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell." [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604]
synonym: "basal ES" EXACT []
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0061833
name: protein localization to tricellular tight junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction." [PMID:24889144]
is_a: GO:0150105 ! protein localization to cell-cell junction

[Term]
id: GO:0061834
name: actin filament branch point
namespace: cellular_component
def: "The part of an actin filament where the structure forks." [PMID:18256280]
synonym: "microfilament branch point" EXACT [GOC:dph]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005884 ! actin filament

[Term]
id: GO:0061835
name: ventral surface of cell
namespace: cellular_component
def: "The surface of a migrating cell that is in contact with the substratum or cell layer." [PMID:11598004]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0061836
name: intranuclear rod
namespace: cellular_component
def: "A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions." [PMID:28074884]
synonym: "intranuclear actin rod" EXACT []
is_a: GO:0099512 ! supramolecular fiber

[Term]
id: GO:0061837
name: neuropeptide processing
namespace: biological_process
def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide." [PMID:12657671, PMID:17564681]
is_a: GO:0140448 ! signaling receptor ligand precursor processing

[Term]
id: GO:0061838
name: CENP-T-W-S-X complex
namespace: cellular_component
def: "A histone-variant containing protein complex which forms a centromere specific nucleosome-like structure, involved in centromeric chromatin organization." [PMID:22304909, PMID:22304917]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0061840
name: high-affinity ferrous iron transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:bhm, PMID:9413439]
synonym: "high affinity ferrous uptake transmembrane transporter activity" EXACT []
synonym: "high-affinity ferrous iron uptake transmembrane transporter activity" EXACT []
is_a: GO:0015093 ! ferrous iron transmembrane transporter activity

[Term]
id: GO:0061841
name: high-affinity iron exporter complex
namespace: cellular_component
def: "A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment." [GOC:bhm, PMID:10608875, PMID:9413439]
comment: An example of this is FET5 in Saccharomyces cerevisiae (P43561) in PMID:9413439.
synonym: "FET5-FTH1 high affinity iron exporter complex" NARROW []
synonym: "FET5-FTH1 high-affinity iron exporter complex" NARROW []
synonym: "high affinity iron exporter complex" EXACT []
is_a: GO:1902495 ! transmembrane transporter complex
is_a: GO:1905862 ! ferroxidase complex
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0061842
name: microtubule organizing center localization
namespace: biological_process
def: "Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell." [PMID:21281821]
synonym: "microtubule organizing center polarity" NARROW []
synonym: "MTOC localization" EXACT []
synonym: "MTOC polarity" NARROW []
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization

[Term]
id: GO:0061843
name: Sertoli cell barrier remodeling
namespace: biological_process
def: "The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle." [PMID:20534520, PMID:24467744]
synonym: "blood testis barrier restructuring" BROAD []
synonym: "restructuring of blood-testis barrier" BROAD []
synonym: "restructuring of BTB" BROAD []
synonym: "restructuring of SCB" EXACT []
synonym: "SCB remodeling" EXACT []
synonym: "Sertoli cell barrier remodelling" EXACT []
synonym: "Sertoli cell barrier restructuring" EXACT []
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0061844
name: antimicrobial humoral immune response mediated by antimicrobial peptide
namespace: biological_process
def: "An immune response against microbes mediated by anti-microbial peptides in body fluid." [PMID:15761415, PMID:24287494]
synonym: "antimicrobial peptide-mediated antimicrobial humoral response" EXACT []
synonym: "peptide-mediated antimicrobial humoral response" BROAD []
is_a: GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0061845
name: neuron projection branch point
namespace: cellular_component
def: "The location where a secondary projection arises from a neuron projection." [PMID:25586189]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0061846
name: dendritic spine cytoplasm
namespace: cellular_component
def: "The region of the neuronal cytoplasm located in dendritic spines." [PMID:15673667]
is_a: GO:0032839 ! dendrite cytoplasm
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0061847
name: response to cholecystokinin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0061848
name: cellular response to cholecystokinin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258]
is_a: GO:0061847 ! response to cholecystokinin
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0061849
name: telomeric G-quadruplex DNA binding
namespace: molecular_function
def: "Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:16142245, PMID:9512530]
is_a: GO:0042162 ! telomeric DNA binding
is_a: GO:0051880 ! G-quadruplex DNA binding

[Term]
id: GO:0061850
name: growth cone leading edge
namespace: cellular_component
def: "That part of the growth cone which represents the distal part of the structure." [PMID:10797548]
is_a: GO:0031252 ! cell leading edge
relationship: part_of GO:0090725 ! peripheral region of growth cone

[Term]
id: GO:0061851
name: leading edge of lamellipodium
namespace: cellular_component
def: "That part of the lamellipodium which represents the distal part of the structure." [PMID:22339865]
is_a: GO:0031252 ! cell leading edge
relationship: part_of GO:0030027 ! lamellipodium

[Term]
id: GO:0061852
name: retrograde transporter complex, Golgi to ER
namespace: cellular_component
def: "Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles." [GOC:bhm, PMID:16093310]
comment: An example of this is ERV41 in Saccharomyces cerevisiae (Q04651) in PMID:16093310 (inferred from direct assay).
synonym: "ERV41-ERV46 retrograde receptor complex" NARROW []
synonym: "retrograde receptor complex, Golgi to endoplasmic reticulum" EXACT []
synonym: "retrograde receptor complex, Golgi to ER" EXACT []
synonym: "retrograde transporter complex, Golgi to endoplasmic reticulum" EXACT []
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:0061853
name: regulation of neuroblast migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0097402 ! neuroblast migration

[Term]
id: GO:0061854
name: positive regulation of neuroblast migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0061853 ! regulation of neuroblast migration
relationship: positively_regulates GO:0097402 ! neuroblast migration

[Term]
id: GO:0061855
name: negative regulation of neuroblast migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0061853 ! regulation of neuroblast migration
relationship: negatively_regulates GO:0097402 ! neuroblast migration

[Term]
id: GO:0061856
name: Golgi calcium ion transmembrane transport
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a Golgi membrane to the other by means of some agent such as a transporter or pore." [PMID:21811607]
is_a: GO:0032472 ! Golgi calcium ion transport
is_a: GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0061857
name: endoplasmic reticulum stress-induced pre-emptive quality control
namespace: biological_process
def: "The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome." [PMID:17129784, PMID:26565908]
synonym: "ER pQC" EXACT []
synonym: "ER stress-indiced pre-emptive quality control" EXACT []
is_a: GO:0034976 ! response to endoplasmic reticulum stress

[Term]
id: GO:0061860
name: DNA clamp unloader activity
namespace: molecular_function
def: "Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis." [GOC:vw, PMID:23499004]
synonym: "DNA clamp unloading activity" EXACT []
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0061862
name: cellular response to differentiation-inducing factor 2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus." [PMID:19684855]
synonym: "cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one" EXACT []
synonym: "cellular response to DIF-2" RELATED []
synonym: "cellular response to DIF2" RELATED []
is_a: GO:0051716 ! cellular response to stimulus
is_a: GO:1905960 ! response to differentiation-inducing factor 2

[Term]
id: GO:0061863
name: microtubule plus end polymerase
namespace: molecular_function
def: "Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversible depending on the availability of dimers." [PMID:27872152]
is_a: GO:0016740 ! transferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0061864
name: basement membrane constituent secretion
namespace: biological_process
def: "The controlled release of molecules that form the basement membrane, including carbohydrates and glycoproteins by a cell." [PMID:26610918, PMID:28228250]
is_a: GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: GO:0061865
name: polarized secretion of basement membrane proteins in epithelium
namespace: biological_process
def: "The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium." [PMID:26610918, PMID:28228250]
is_a: GO:0061864 ! basement membrane constituent secretion

[Term]
id: GO:0061866
name: obsolete negative regulation of histone H3-S10 phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to histone H3 on a serine residue at position 10." [PMID:27521428]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0004860

[Term]
id: GO:0061867
name: establishment of mitotic spindle asymmetry
namespace: biological_process
def: "The mitotic spindle organization process by which a mitotic spindle becomes asymmetric either in position or structure." [PMID:26659188]
is_a: GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0061868
name: hepatic stellate cell migration
namespace: biological_process
def: "The orderly movement of a hepatic stellate cell from one site to another." [PMID:24204762]
is_a: GO:0010761 ! fibroblast migration

[Term]
id: GO:0061869
name: regulation of hepatic stellate cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762]
is_a: GO:0010762 ! regulation of fibroblast migration
relationship: regulates GO:0061868 ! hepatic stellate cell migration

[Term]
id: GO:0061870
name: positive regulation of hepatic stellate cell migration
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762]
is_a: GO:0010763 ! positive regulation of fibroblast migration
is_a: GO:0061869 ! regulation of hepatic stellate cell migration
relationship: positively_regulates GO:0061868 ! hepatic stellate cell migration

[Term]
id: GO:0061871
name: negative regulation of hepatic stellate cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762]
is_a: GO:0010764 ! negative regulation of fibroblast migration
is_a: GO:0061869 ! regulation of hepatic stellate cell migration
relationship: negatively_regulates GO:0061868 ! hepatic stellate cell migration

[Term]
id: GO:0061872
name: hepatic stellate cell contraction
namespace: biological_process
def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a hepatic stellate cell." [PMID:24204762]
is_a: GO:0070252 ! actin-mediated cell contraction

[Term]
id: GO:0061873
name: regulation of hepatic stellate cell contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762]
is_a: GO:1903115 ! regulation of actin filament-based movement
relationship: regulates GO:0061872 ! hepatic stellate cell contraction

[Term]
id: GO:0061874
name: positive regulation of hepatic stellate cell contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762]
is_a: GO:0061873 ! regulation of hepatic stellate cell contraction
is_a: GO:1903116 ! positive regulation of actin filament-based movement
relationship: positively_regulates GO:0061872 ! hepatic stellate cell contraction

[Term]
id: GO:0061875
name: negative regulation of hepatic stellate cell contraction
namespace: biological_process
def: "Any process that modulates stops, prevents, or reduces the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0061873 ! regulation of hepatic stellate cell contraction
relationship: negatively_regulates GO:0061872 ! hepatic stellate cell contraction

[Term]
id: GO:0061880
name: regulation of anterograde axonal transport of mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729]
synonym: "regulation of anterograde axon transport of mitochondria" EXACT []
is_a: GO:1902513 ! regulation of organelle transport along microtubule
relationship: regulates GO:0098957 ! anterograde axonal transport of mitochondrion

[Term]
id: GO:0061881
name: positive regulation of anterograde axonal transport of mitochondrion
namespace: biological_process
def: "Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729]
synonym: "positive regulation of anterograde axon transport of mitochondria" EXACT []
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion
relationship: positively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion

[Term]
id: GO:0061882
name: negative regulation of anterograde axonal transport of mitochondrion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729]
synonym: "negative regulation of anterograde axon transport of mitochondria" EXACT []
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion
relationship: negatively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion

[Term]
id: GO:0061883
name: clathrin-dependent endocytosis involved in vitellogenesis
namespace: biological_process
def: "A clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition." [PMID:26265702]
synonym: "clathrin-dependent endocytosis involved in yolk formation" EXACT []
is_a: GO:0072583 ! clathrin-dependent endocytosis
relationship: part_of GO:0007296 ! vitellogenesis

[Term]
id: GO:0061884
name: regulation of mini excitatory postsynaptic potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454]
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
relationship: regulates GO:0098816 ! mini excitatory postsynaptic potential

[Term]
id: GO:0061885
name: positive regulation of mini excitatory postsynaptic potential
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454]
is_a: GO:0061884 ! regulation of mini excitatory postsynaptic potential
is_a: GO:2000463 ! positive regulation of excitatory postsynaptic potential
relationship: positively_regulates GO:0098816 ! mini excitatory postsynaptic potential

[Term]
id: GO:0061886
name: negative regulation of mini excitatory postsynaptic potential
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454]
is_a: GO:0061884 ! regulation of mini excitatory postsynaptic potential
is_a: GO:0090394 ! negative regulation of excitatory postsynaptic potential
relationship: negatively_regulates GO:0098816 ! mini excitatory postsynaptic potential

[Term]
id: GO:0061887
name: obsolete reproduction of symbiont in host
namespace: biological_process
def: "OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms, occurring within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23460907, PMID:25713147]
comment: This term was obsoleted because it represents a process and a component.
is_obsolete: true

[Term]
id: GO:0061888
name: regulation of astrocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821]
is_a: GO:0048710 ! regulation of astrocyte differentiation
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0048143 ! astrocyte activation

[Term]
id: GO:0061889
name: negative regulation of astrocyte activation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821]
is_a: GO:0048712 ! negative regulation of astrocyte differentiation
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:0061888 ! regulation of astrocyte activation
is_a: GO:0150079 ! negative regulation of neuroinflammatory response
relationship: negatively_regulates GO:0048143 ! astrocyte activation

[Term]
id: GO:0061890
name: positive regulation of astrocyte activation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821]
is_a: GO:0048711 ! positive regulation of astrocyte differentiation
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:0061888 ! regulation of astrocyte activation
is_a: GO:0150078 ! positive regulation of neuroinflammatory response
relationship: positively_regulates GO:0048143 ! astrocyte activation

[Term]
id: GO:0061891
name: calcium ion sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+)." [PMID:16005298, PMID:17020874, PMID:28151650]
is_a: GO:0140784 ! metal ion sensor activity

[Term]
id: GO:0061896
name: all-trans retinol 3,4-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinol + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013]
xref: RHEA:50292
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0061897
name: all-trans retinal 3,4-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0061898
name: all-trans retinoic acid 3,4-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinoic acid + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0061899
name: 11-cis-retinal 3,4-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-cis-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0061900
name: glial cell activation
namespace: biological_process
def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0150076 ! neuroinflammatory response

[Term]
id: GO:0061901
name: obsolete regulation of 1-phosphatidylinositol-3-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061902
name: obsolete negative regulation of 1-phosphatidylinositol-3-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061903
name: obsolete positive regulation of 1-phosphatidylinositol-3-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that starts or increases the frequency or rate of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035014

[Term]
id: GO:0061906
name: autophagosome localization
namespace: biological_process
def: "Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell." [PMID:26763909]
is_a: GO:1990849 ! vacuolar localization

[Term]
id: GO:0061907
name: negative regulation of AMPA receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor activity." [GOC:aruk, GOC:bc, PMID:20739563]
subset: gocheck_obsoletion_candidate
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1900450 ! negative regulation of glutamate receptor signaling pathway
is_a: GO:2000272 ! negative regulation of signaling receptor activity
is_a: GO:2000311 ! regulation of AMPA receptor activity

[Term]
id: GO:0061908
name: phagophore
namespace: cellular_component
def: "A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle." [PMID:22664348, PMID:24201109]
synonym: "isolation membrane" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0061909
name: autophagosome-lysosome fusion
namespace: biological_process
def: "The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [PMID:28077293]
synonym: "autophagosome fusion" BROAD []
synonym: "autophagosome-vacuole fusion" EXACT []
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0061910
name: autophagosome-endosome fusion
namespace: biological_process
def: "The process in which an autophagosome fuses with an endosome to create an intermediate autophagic organelle called amphisome." [PMID:24219988]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0061911
name: amphisome-lysosome fusion
namespace: biological_process
def: "The process in which amphisomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the amphisome." [PMID:24219988]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0061912
name: obsolete selective autophagy
namespace: biological_process
def: "OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0061913
name: positive regulation of growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [PMID:19264869]
is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation
is_a: GO:0008284 ! positive regulation of cell population proliferation
relationship: positively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation

[Term]
id: GO:0061914
name: negative regulation of growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [PMID:19264869]
is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0046621 ! negative regulation of organ growth
relationship: negatively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation

[Term]
id: GO:0061915
name: obsolete actin fusion focus localization
namespace: biological_process
def: "OBSOLETE. Any process in which an actin fusion focus are transported to, or maintained in, a specific location. The actin fusion focus is an aster-like, F-actin-containing structure at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion." [PMID:28410370]
comment: The reason for obsoletion is that this represents a phenotype.
synonym: "actin fusion focus localisation" EXACT []
is_obsolete: true

[Term]
id: GO:0061916
name: leading edge of axonal growth cone
namespace: cellular_component
def: "That part of the axonal growth cone which represents the distal part of the structure." [PMID:16098134]
synonym: "axonal growth cone leading edge" EXACT []
synonym: "distal tip of axonal growth cone" EXACT []
is_a: GO:0061850 ! growth cone leading edge
relationship: part_of GO:0044295 ! axonal growth cone

[Term]
id: GO:0061917
name: leading edge of dendritic growth cone
namespace: cellular_component
def: "That part of the dendritic growth cone which represents the distal part of the structure." [PMID:16098134]
synonym: "dendritic growth cone leading edge" EXACT []
synonym: "distal tip of dendritic growth cone" EXACT []
is_a: GO:0061850 ! growth cone leading edge
relationship: part_of GO:0044294 ! dendritic growth cone

[Term]
id: GO:0061919
name: process utilizing autophagic mechanism
namespace: biological_process
def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0061920
name: protein propionyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide." [PMID:17267393]
xref: RHEA:54020
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0061921
name: peptidyl-lysine propionylation
namespace: biological_process
def: "The propionylation of peptidyl-lysine." [PMID:17267393]
subset: gocheck_obsoletion_candidate
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0061922
name: histone propionyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone." [PMID:17267393]
is_a: GO:0061920 ! protein propionyltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0061923
name: (2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene." [PMID:27862766]
synonym: "protoillud-7-ene synthase activity" RELATED []
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0061924
name: regulation of formation of radial glial scaffolds
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells." [PMID:22076441]
synonym: "regulation of Bergmann fiber biosynthesis" RELATED []
synonym: "regulation of Bergmann fiber formation" RELATED []
synonym: "regulation of radial glial scaffold formation" EXACT []
is_a: GO:0022604 ! regulation of cell morphogenesis
relationship: regulates GO:0021943 ! formation of radial glial scaffolds

[Term]
id: GO:0061925
name: negative regulation of formation of radial glial scaffolds
namespace: biological_process
def: "Any process that reduces the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells." [PMID:22076441]
synonym: "negative regulation of Bergmann fiber biosynthesis" RELATED []
synonym: "negative regulation of Bergmann fiber formation" RELATED []
synonym: "negative regulation of radial glial scaffold formation" EXACT []
is_a: GO:0010771 ! negative regulation of cell morphogenesis
is_a: GO:0061924 ! regulation of formation of radial glial scaffolds
relationship: negatively_regulates GO:0021943 ! formation of radial glial scaffolds

[Term]
id: GO:0061926
name: positive regulation of formation of radial glial scaffolds
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the formation of radial glial cell scaffolds." [PMID:22076441]
synonym: "positive regulation of Bergmann fiber biosynthesis" RELATED []
synonym: "positive regulation of Bergmann fiber formation" RELATED []
synonym: "positive regulation of radial glial scaffold formation" EXACT []
is_a: GO:0010770 ! positive regulation of cell morphogenesis
is_a: GO:0061924 ! regulation of formation of radial glial scaffolds
relationship: positively_regulates GO:0021943 ! formation of radial glial scaffolds

[Term]
id: GO:0061927
name: TOC-TIC supercomplex I
namespace: cellular_component
def: "The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110." [PMID:28745032]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0061928
name: glutathione specific gamma-glutamylcyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine." [PMID:23070364, PMID:27913623]
xref: EC:4.3.2.7
xref: RHEA:47724
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0061929
name: gamma-glutamylaminecyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline." [PMID:20110353, PMID:6107907]
xref: EC:4.3.2.8
xref: RHEA:16961
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0061930
name: regulation of erythrocyte enucleation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903429 ! regulation of cell maturation
relationship: regulates GO:0043131 ! erythrocyte enucleation

[Term]
id: GO:0061931
name: positive regulation of erythrocyte enucleation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0061930 ! regulation of erythrocyte enucleation
relationship: positively_regulates GO:0043131 ! erythrocyte enucleation

[Term]
id: GO:0061932
name: negative regulation of erythrocyte enucleation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0061930 ! regulation of erythrocyte enucleation
is_a: GO:1903430 ! negative regulation of cell maturation
relationship: negatively_regulates GO:0043131 ! erythrocyte enucleation

[Term]
id: GO:0061934
name: regulation of adenine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an adenine biosynthetic process." [PMID:19933844]
is_a: GO:0006141 ! regulation of purine nucleobase metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0046084 ! adenine biosynthetic process

[Term]
id: GO:0061935
name: fusion of sperm to egg plasma membrane involved in double fertilization forming two zygotes
namespace: biological_process
def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming two zygotes." [GOC:dph]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0009677 ! double fertilization forming two zygotes

[Term]
id: GO:0061936
name: fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm
namespace: biological_process
def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming a zygote and endosperm." [PMID:21123745]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0009567 ! double fertilization forming a zygote and endosperm

[Term]
id: GO:0061938
name: protein localization to somatodendritic compartment
namespace: biological_process
def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993]
synonym: "somatodendritic protein localization" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0061939
name: c-di-GMP signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal." [PMID:22864416, PMID:28057864]
synonym: "3',5'-cyclic di-GMP signaling" EXACT []
synonym: "cyclic di-(3':5')-guanosine monophosphate signaling" EXACT []
synonym: "cyclic di-GMP signaling" EXACT []
synonym: "cyclic diguanylate signaling" EXACT []
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0061940
name: regulation of c-di-GMP signaling
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of c-di-GMP signaling." [PMID:22864416]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
relationship: regulates GO:0061939 ! c-di-GMP signaling

[Term]
id: GO:0061941
name: positive regulation of c-di-GMP signaling
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of c-di-GMP signaling." [PMID:22864416]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0061940 ! regulation of c-di-GMP signaling
relationship: positively_regulates GO:0061939 ! c-di-GMP signaling

[Term]
id: GO:0061942
name: negative regulation of c-di-GMP signaling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of c-di-GMP signaling." [PMID:22864416]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0061940 ! regulation of c-di-GMP signaling
relationship: negatively_regulates GO:0061939 ! c-di-GMP signaling

[Term]
id: GO:0061944
name: negative regulation of protein K48-linked ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:BHF, GOC:rph, PMID:23460740]
is_a: GO:0061945 ! regulation of protein K48-linked ubiquitination
is_a: GO:1902915 ! negative regulation of protein polyubiquitination
relationship: negatively_regulates GO:0070936 ! protein K48-linked ubiquitination

[Term]
id: GO:0061945
name: regulation of protein K48-linked ubiquitination
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [PMID:23460740]
is_a: GO:1902914 ! regulation of protein polyubiquitination
relationship: regulates GO:0070936 ! protein K48-linked ubiquitination

[Term]
id: GO:0061948
name: premature acrosome loss
namespace: biological_process
def: "The discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:19153666, PMID:21380641, PMID:26655718]
comment: If the release of the acrosome content when the sperm reaches to the zona pellucida, consider using acrosome reaction.
synonym: "spontaneous acrosome loss" EXACT []
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0061949
name: regulation of premature acrosome loss
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:22228629, PMID:23430248]
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0061948 ! premature acrosome loss

[Term]
id: GO:0061950
name: negative regulation of premature acrosome loss
namespace: biological_process
def: "Any process that stops, prevents or reduces the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:22228629, PMID:23430248]
synonym: "negative regulation of spontaneous acrosome loss" EXACT []
is_a: GO:0061949 ! regulation of premature acrosome loss
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0061948 ! premature acrosome loss

[Term]
id: GO:0061951
name: establishment of protein localization to plasma membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw]
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0061952
name: midbody abscission
namespace: biological_process
def: "The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells." [PMID:12737809, PMID:29903934]
synonym: "cell separation during cytokinesis" EXACT []
synonym: "cytokinetic abscission" EXACT []
is_a: GO:0061024 ! membrane organization
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:0061953
name: mRNA (adenine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA." [PMID:29072297]
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0061954
name: obsolete positive regulation of actin filament polymerization involved in sperm capacitation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate or extent of actin polymerization as part of sperm capacitation. This process prevents a spontaneous acrosome reaction." [PMID:15749953, PMID:25966627, PMID:26514336, PMID:27178669]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0061955
name: obsolete positive regulation of actin filament depolymerization involved in acrosome reaction
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate or extent of actin depolymerization as part of the acrosome reaction. This allows the acrosomal membrane and plasma membrane to fuse." [PMID:20937821]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0061956
name: penetration of cumulus oophorus
namespace: biological_process
def: "The infiltration by sperm of the cumulus oophorus to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [PMID:21380641]
synonym: "penetration of cumulus cells layer" EXACT []
synonym: "penetration of cumulus mass" EXACT []
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0061957
name: NVT complex
namespace: cellular_component
def: "A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1." [PMID:26365378]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0061959
name: response to (R)-carnitine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus." [PMID:28102299]
synonym: "response to L-carnitine" EXACT []
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0061960
name: regulation of heme oxygenase activity
namespace: biological_process
def: "Any process that modulates the frequency, or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779]
subset: gocheck_obsoletion_candidate
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0061961
name: obsolete positive regulation of heme oxygenase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061962
name: obsolete negative regulation of heme oxygenase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0061963
name: regulation of entry into reproductive diapause
namespace: biological_process
def: "Any process that modulates the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0055116 ! entry into reproductive diapause

[Term]
id: GO:0061964
name: negative regulation of entry into reproductive diapause
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0061963 ! regulation of entry into reproductive diapause
relationship: negatively_regulates GO:0055116 ! entry into reproductive diapause

[Term]
id: GO:0061965
name: positive regulation of entry into reproductive diapause
namespace: biological_process
def: "Any process that activates or increases the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0061963 ! regulation of entry into reproductive diapause
relationship: positively_regulates GO:0055116 ! entry into reproductive diapause

[Term]
id: GO:0061966
name: establishment of left/right asymmetry
namespace: biological_process
def: "The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866]
is_a: GO:0007368 ! determination of left/right symmetry

[Term]
id: GO:0061967
name: establishment of left sidedness
namespace: biological_process
def: "The initial formation of the type asymmetry in an organism's body plan or part of an organism that established the pattern characteristic to its left side." [GOC:18629866, GOC:BHF]
is_a: GO:0061966 ! establishment of left/right asymmetry

[Term]
id: GO:0061968
name: maintenance of left/right asymmetry
namespace: biological_process
def: "The organization process that preserves the asymmetry in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0061969
name: maintenance of left sidedness
namespace: biological_process
def: "The organization process that preserves the left sidedness in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866]
is_a: GO:0061968 ! maintenance of left/right asymmetry

[Term]
id: GO:0061970
name: maintenance of right sidedness
namespace: biological_process
def: "The organization process that preserves the right sidedness in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866]
is_a: GO:0061968 ! maintenance of left/right asymmetry

[Term]
id: GO:0061971
name: replacement bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [PMID:29852585]
is_a: GO:0060349 ! bone morphogenesis

[Term]
id: GO:0061972
name: dermal bone morphogenesis
namespace: biological_process
def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632]
is_a: GO:0061973 ! membrane bone morphogenesis

[Term]
id: GO:0061973
name: membrane bone morphogenesis
namespace: biological_process
def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374]
is_a: GO:0060349 ! bone morphogenesis

[Term]
id: GO:0061974
name: perichondral bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone." [PMID:21901110]
is_a: GO:0060350 ! endochondral bone morphogenesis
is_a: GO:0061973 ! membrane bone morphogenesis

[Term]
id: GO:0061975
name: articular cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure." [PMID:20097540, PMID:20679519]
synonym: "articular cartilage of joint development" EXACT []
is_a: GO:0051216 ! cartilage development

[Term]
id: GO:0061976
name: temporomandibular joint articular cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of temporomandibular joint articular cartilage over time, from its formation to the mature structure." [PMID:20679519]
is_a: GO:0061975 ! articular cartilage development

[Term]
id: GO:0061977
name: hip joint articular cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of hip joint articular cartilage over time, from its formation to the mature structure." [PMID:20097540]
is_a: GO:0061975 ! articular cartilage development

[Term]
id: GO:0061978
name: mandibular condyle articular cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure." [PMID:20679519]
is_a: GO:0061976 ! temporomandibular joint articular cartilage development

[Term]
id: GO:0061979
name: femoral head articular cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of femoral head articular cartilage over time, from its formation to the mature structure." [PMID:20097540]
is_a: GO:0061977 ! hip joint articular cartilage development

[Term]
id: GO:0061980
name: regulatory RNA binding
namespace: molecular_function
def: "Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme." [PMID:14622403, PMID:23475961]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0061981
name: obsolete 3-hydroxykynureninase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine." [PMID:17300176]
comment: This term was obsoleted because it represents the same activity as kynureninase activity ; GO:0030429.
is_obsolete: true
replaced_by: GO:0030429

[Term]
id: GO:0061982
name: meiosis I cell cycle process
namespace: biological_process
def: "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397]
synonym: "first meiotic cell division" EXACT [PMID:29385397]
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0061983
name: meiosis II cell cycle process
namespace: biological_process
def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397]
synonym: "second meiotic division" EXACT [PMID:29385397]
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0061984
name: catabolite repression
namespace: biological_process
def: "A process in which the presence of one nutrient source leads to a decrease in the frequency, rate, or extent of processes involved in the metabolism of other nutrient sources." [GOC:dph, PMID:29197127, PMID:29295552]
is_a: GO:0031670 ! cellular response to nutrient
relationship: negatively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0061985
name: carbon catabolite repression
namespace: biological_process
def: "A process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of the metabolism of other carbon sources." [PMID:29295552]
is_a: GO:0061984 ! catabolite repression

[Term]
id: GO:0061986
name: negative regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that decreases the frequency, rate or extent or transcription." [PMID:11875061]
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0061987
name: negative regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter." [PMID:11875061]
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0061986 ! negative regulation of transcription by glucose

[Term]
id: GO:0061988
name: karyosome formation
namespace: biological_process
def: "The chromosome organization process in which meiotic chromosomes in the germ cell nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:19696886]
is_a: GO:0061982 ! meiosis I cell cycle process
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0061989
name: sperm karyosome formation
namespace: biological_process
def: "The chromosome organization process in which meiotic chromosomes in the spem nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:19696886]
is_a: GO:0061988 ! karyosome formation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0061990
name: beta-ketodecanoyl-[acyl-carrier-protein] synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoyl-CoA + H+ + malonyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + CoA." [PMID:22753057, RHEA:42264]
xref: EC:2.3.1.207
xref: MetaCyc:RXN-13613
xref: RHEA:42264
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0061992
name: obsolete ATP-dependent chaperone mediated protein folding
namespace: biological_process
def: "OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and dependent on ATP hydrolysis." [PMID:18311152]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0140662

[Term]
id: GO:0061993
name: calcium:proton antiporter complex
namespace: cellular_component
def: "A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [GOC:bhm, PMID:19098009, PMID:28645169]
synonym: "CAX1 homodimer" NARROW [GOC:bhm]
synonym: "CAX1-CAX3 complex" NARROW [GOC:bhm]
synonym: "CAX3 homodimer" NARROW [GOC:bhm]
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:0061995
name: ATP-dependent protein-DNA complex displacement activity
namespace: molecular_function
alt_id: GO:0061994
def: "An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis." [PMID:18593879]
synonym: "ATP-dependent protein-nucleic acid complex displacement activity" NARROW []
xref: Reactome:R-HSA-9822115 "NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA"
is_a: GO:0140083 ! ATP-dependent protein-DNA unloader activity

[Term]
id: GO:0061999
name: regulation of cardiac endothelial to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac endothelial to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0140074 ! cardiac endothelial to mesenchymal transition

[Term]
id: GO:0062000
name: positive regulation of cardiac endothelial to mesenchymal transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061999 ! regulation of cardiac endothelial to mesenchymal transition
relationship: positively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition

[Term]
id: GO:0062001
name: negative regulation of cardiac endothelial to mesenchymal transition
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac endothelial to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061999 ! regulation of cardiac endothelial to mesenchymal transition
relationship: negatively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition

[Term]
id: GO:0062002
name: regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
namespace: biological_process
def: "Any process that modulates the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971]
subset: gocheck_obsoletion_candidate
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0062003
name: negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
namespace: biological_process
def: "Any process that decreases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971]
subset: gocheck_obsoletion_candidate
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0062002 ! regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
is_a: GO:0062014 ! negative regulation of small molecule metabolic process

[Term]
id: GO:0062009
name: secondary palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences." [PMID:28784960]
is_a: GO:0060021 ! roof of mouth development

[Term]
id: GO:0062010
name: primitive palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the primitive palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure." [GOC:dph]
is_a: GO:0060021 ! roof of mouth development

[Term]
id: GO:0062011
name: mitochondrial respiratory chain complex IV pre-assembly complex
namespace: cellular_component
def: "A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components." [GOC:lnp, PMID:21068384]
synonym: "COX pre-assemply complex" BROAD [GOC:lnp]
synonym: "COX1 preassemply complex" EXACT [GOC:lnp]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
is_a: GO:0101031 ! protein folding chaperone complex

[Term]
id: GO:0062012
name: regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]
synonym: "regulation of small molecule metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0062013
name: positive regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]
synonym: "positive regulation of small molecule metabolism" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: positively_regulates GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0062014
name: negative regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]
synonym: "negative regulation of small molecule metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: negatively_regulates GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0062021
name: obsolete mitotic cohesin dsDNA (leading strand) loading
namespace: biological_process
def: "OBSOLETE. The protein localization to chromatin by which a cohesin ring complex is topologically linked to dsDNA (leading strand) as part of the mitotic cell cycle." [GOC:vw, PMID:29358048]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true

[Term]
id: GO:0062022
name: obsolete mitotic cohesin ssDNA (lagging strand) loading
namespace: biological_process
def: "OBSOLETE. The ATP-dependent protein localization to chromatin by which a cohesin ring complex is topologically linked to ssDNA (lagging strand) which is already linked to a dsDNA (leading strand) molecule as part of the mitotic cell cycle." [GOC:vw, PMID:29358048]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "second-DNA capture" EXACT [GOC:vw]
is_obsolete: true

[Term]
id: GO:0062023
name: collagen-containing extracellular matrix
namespace: cellular_component
def: "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0062025
name: regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894]
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
relationship: regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0062026
name: negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
namespace: biological_process
def: "Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894]
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0062025 ! regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
relationship: negatively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0062027
name: positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
namespace: biological_process
def: "Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0062025 ! regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
relationship: positively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0062028
name: regulation of stress granule assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778]
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0034063 ! stress granule assembly

[Term]
id: GO:0062029
name: positive regulation of stress granule assembly
namespace: biological_process
def: "Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778]
is_a: GO:0062028 ! regulation of stress granule assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0034063 ! stress granule assembly

[Term]
id: GO:0062030
name: negative regulation of stress granule assembly
namespace: biological_process
def: "Any process that stops or decreases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778]
is_a: GO:0062028 ! regulation of stress granule assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0034063 ! stress granule assembly

[Term]
id: GO:0062031
name: filamentous growth MAPK cascade
namespace: biological_process
def: "A MAPK cascade containing at least the Kss1 MAP kinase. It starts with the activation of Ste20, a MAP4K, which activates Ste11, a MAP3K, which in turn activate Ste7, a MAP2K, which activates Kss1. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The filamentous growth MAPK cascade is activated as a result of partial nutrient deprivation and  results in filamentous growth." [PMID:17604854, PMID:33335117, PMID:38187743]
is_a: GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0062032
name: cichorine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cichorine, a secondary metabolite found in some species of fungi." [PMID:24244835]
synonym: "cichorine anabolism" EXACT []
synonym: "cichorine biosynthesis" EXACT []
synonym: "cichorine formation" EXACT []
synonym: "cichorine synthesis" EXACT []
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0062033
name: positive regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0062034
name: L-pipecolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-pipecolic acid, a metabolite of lysine." [PMID:27758894, PMID:28330936]
synonym: "L-pipecolate biosynthetic process" EXACT []
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0062035
name: sensory perception of cold stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a cold temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal." [PMID:21335241]
is_a: GO:0050955 ! thermoception

[Term]
id: GO:0062036
name: sensory perception of hot stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a hot temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal." [PMID:21335241]
is_a: GO:0050955 ! thermoception

[Term]
id: GO:0062037
name: D-loop DNA binding
namespace: molecular_function
def: "Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind." [PMID:20924116]
synonym: "DNA displacement loop binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0062038
name: positive regulation of pheromone response MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade." [PMID:9315645]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0180039 ! regulation of pheromone response MAPK cascade
relationship: positively_regulates GO:0071507 ! pheromone response MAPK cascade

[Term]
id: GO:0062039
name: biofilm matrix
namespace: cellular_component
def: "A type of extracellular matrix that surrounds the cells within a microbial biofilm. The matrix is composed of extracellular polymeric substances including exopolysaccharides, proteins, nucleic acids, lipids, and other biomolecules." [PMID:22571672, PMID:27129222, PMID:28516088, PMID:32663461]
subset: gocheck_do_not_annotate
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0062040
name: fungal biofilm matrix
namespace: cellular_component
def: "An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses." [GOC:BHF, PMID:27129222, PMID:28516088]
is_a: GO:0062039 ! biofilm matrix

[Term]
id: GO:0062041
name: positive regulation of meiotic sister chromatid arm separation
namespace: biological_process
def: "Any process that increases the rate or extent of meiotic sister chromatid arm separation, the cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [PMID:20383139]
is_a: GO:1905134 ! positive regulation of meiotic chromosome separation
relationship: positively_regulates GO:0051755 ! meiotic sister chromatid arm separation

[Term]
id: GO:0062042
name: regulation of cardiac epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:rph, PMID:20951801]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
relationship: regulates GO:0060317 ! cardiac epithelial to mesenchymal transition

[Term]
id: GO:0062043
name: positive regulation of cardiac epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:rph, PMID:20951801]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition
relationship: positively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition

[Term]
id: GO:0062044
name: negative regulation of cardiac epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BFH, GOC:rph, PMID:20951801]
is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition
is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition
relationship: negatively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition

[Term]
id: GO:0062045
name: L-lysine alpha-aminotransferase
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine." [PMID:27758894, PMID:28330936]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0062046
name: dehydropipecolic acid reductase
namespace: molecular_function
def: "Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+." [PMID:27758894, PMID:28330936]
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0062047
name: pipecolic acid N-hydroxylase
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O." [PMID:27758894, PMID:28330936]
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0062048
name: lymphotoxin complex
namespace: cellular_component
def: "A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations." [PMID:1733951]
synonym: "lymphotoxin alpha-beta" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0062049
name: protein phosphatase inhibitor complex
namespace: cellular_component
def: "A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase." [GOC:bhm, PMID:19407142, PMID:19933100]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0062050
name: GPI-mannose ethanolamine phosphate phosphodiesterase activity
namespace: molecular_function
def: "A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor." [PMID:19837036]
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0062051
name: lipopolysaccharide transport system
namespace: cellular_component
def: "A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner." [PMID:29449493]
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:0062052
name: starch granule initiation
namespace: biological_process
def: "The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts." [PMID:28684429]
is_a: GO:0019252 ! starch biosynthetic process

[Term]
id: GO:0062054
name: fluoride channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel." [PMID:23991286, PMID:25156118]
is_a: GO:0005253 ! monoatomic anion channel activity
is_a: GO:1903425 ! fluoride transmembrane transporter activity

[Term]
id: GO:0062055
name: photosynthetic state transition
namespace: biological_process
def: "A regulation of the phtosynthetic light reaction in which the light harvesting antenna complexes transition between photosystems." [PMID:29967049]
is_a: GO:0042548 ! regulation of photosynthesis, light reaction

[Term]
id: GO:0062056
name: compound eye pigment cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia." [GOC:ha, PMID:8929534]
is_a: GO:0050931 ! pigment cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0062057
name: L-aspartate:fumarate antiporter activity
namespace: molecular_function
def: "Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out)." [PMID:29995997]
is_a: GO:0015138 ! fumarate transmembrane transporter activity
is_a: GO:0015183 ! L-aspartate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0062058
name: transcription factor TFIIH holo complex binding
namespace: molecular_function
def: "Binding to a transcription factor TFIIH holo complex." [PMID:11259578]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062059
name: FACT complex binding
namespace: molecular_function
def: "Binding to a FACT complex." [PMID:10682845]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062060
name: NuA4 histone acetyltransferase complex binding
namespace: molecular_function
def: "Binding to a NuA4 histone acetyltransferase complex." [PMID:15528408]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062061
name: TAP complex binding
namespace: molecular_function
def: "Binding to a TAP complex." [PMID:17947644]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062062
name: oligosaccharyltransferase complex binding
namespace: molecular_function
def: "Binding to an oligosaccharyltransferase complex." [PMID:12887896]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062063
name: BBSome binding
namespace: molecular_function
def: "Binding to a BBSome complex." [PMID:20603001]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062064
name: box C/D methylation guide snoRNP complex binding
namespace: molecular_function
def: "Binding to a box C/D methylation guide snoRNP complex." [PMID:10679015]
is_a: GO:0030519 ! snoRNP binding

[Term]
id: GO:0062065
name: box H/ACA snoRNP complex binding
namespace: molecular_function
def: "Binding to a box H/ACA snoRNP complex." [PMID:10679015]
is_a: GO:0030519 ! snoRNP binding

[Term]
id: GO:0062066
name: PSII associated light-harvesting complex II binding
namespace: molecular_function
def: "Binding to a PSII associated light-harvesting complex II." [PMID:17400553]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062067
name: chloroplast photosystem I binding
namespace: molecular_function
def: "Binding to a chloroplast photosystem I." [PMID:17400553]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062068
name: chloroplast photosystem II binding
namespace: molecular_function
def: "Binding to a chloroplast photosystem II." [PMID:17400553]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062069
name: GARP complex binding
namespace: molecular_function
def: "Binding to a GARP complex." [PMID:20163565]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062070
name: SAGA complex binding
namespace: molecular_function
def: "Binding to a SAGA complex." [PMID:27185460]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062071
name: Pi Mi complex
namespace: cellular_component
def: "A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis." [PMID:30089908]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0062072
name: H3K9me3 histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone H3 trimethylated at lysine 9." [PMID:30110338]
synonym: "H3K9me3 modified histone binding" NARROW []
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:0062073
name: histone mRNA stem-loop binding complex
namespace: cellular_component
def: "A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export." [GOC:bhm, PMID:18025107, PMID:23286197]
synonym: "SLBP-MIF4GD complex" NARROW []
synonym: "SLBP-SLIP1 complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0062074
name: pollen aperture
namespace: cellular_component
def: "An area where exine is reduced or absent, in the pollen wall." [PMID:30150313]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0062075
name: pollen aperture formation
namespace: biological_process
def: "The cellular component assembly process of forming pollen apertures, areas where exine is reduced or absent, in the pollen cell wall." [PMID:30150313]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0010208 ! pollen wall assembly

[Term]
id: GO:0062076
name: acyl-CoA delta5-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA)." [PMID:10601301, PMID:10769175, RHEA:46424]
synonym: "acyl-CoA (8-3)-desaturase" EXACT []
synonym: "acyl-CoA D5-desaturase activity" EXACT []
synonym: "acyl-CoA delta(5)-desaturase activity" EXACT []
xref: EC:1.14.19.44
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0062077
name: phenylacetyl-CoA 1,2-epoxidase complex
namespace: cellular_component
def: "A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+." [GOC:bhm, PMID:21247899]
synonym: "paaABCE complex" NARROW []
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0062078
name: TSC1-TSC2 complex binding
namespace: molecular_function
def: "Binding to a TSC1-TSC2 complex." [PMID:28561066]
synonym: "tuberin sclerosis complex binding" EXACT []
synonym: "tuberin-hamartin complex binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0062079
name: ATG2-ATG18 complex
namespace: cellular_component
def: "A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae." [GOC:bhm, PMID:23230146]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0034045 ! phagophore assembly site membrane

[Term]
id: GO:0062080
name: inhibitory MHC class Ib receptor activity
namespace: molecular_function
def: "Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246]
is_a: GO:0032394 ! MHC class Ib receptor activity

[Term]
id: GO:0062081
name: activating MHC class Ib receptor activity
namespace: molecular_function
def: "Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte." [DOI:10.1002/9780470015902.a0024246]
is_a: GO:0032394 ! MHC class Ib receptor activity

[Term]
id: GO:0062082
name: HLA-E specific inhibitory MHC class Ib receptor activity
namespace: molecular_function
def: "Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246]
is_a: GO:0062080 ! inhibitory MHC class Ib receptor activity

[Term]
id: GO:0062083
name: HLA-G specific inhibitory MHC class Ib receptor activity
namespace: molecular_function
def: "Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246]
is_a: GO:0062080 ! inhibitory MHC class Ib receptor activity

[Term]
id: GO:0062084
name: regulation of capsule polysaccharide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [PMID:21917918]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
is_a: GO:1901913 ! regulation of capsule organization
relationship: regulates GO:0045227 ! capsule polysaccharide biosynthetic process

[Term]
id: GO:0062085
name: positive regulation of capsule polysaccharide biosynthetic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [PMID:21917918]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0062084 ! regulation of capsule polysaccharide biosynthetic process
is_a: GO:1901915 ! positive regulation of capsule organization
relationship: positively_regulates GO:0045227 ! capsule polysaccharide biosynthetic process

[Term]
id: GO:0062086
name: regulation of vein smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203]
is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
relationship: regulates GO:0014826 ! vein smooth muscle contraction

[Term]
id: GO:0062087
name: positive regulation of vein smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203]
is_a: GO:0062086 ! regulation of vein smooth muscle contraction
is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction
relationship: positively_regulates GO:0014826 ! vein smooth muscle contraction

[Term]
id: GO:0062088
name: negative regulation of vein smooth muscle contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203]
is_a: GO:0062086 ! regulation of vein smooth muscle contraction
is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction
relationship: negatively_regulates GO:0014826 ! vein smooth muscle contraction

[Term]
id: GO:0062089
name: regulation of taurine biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0042412 ! taurine biosynthetic process

[Term]
id: GO:0062090
name: positive regulation of taurine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0062089 ! regulation of taurine biosynthetic process
relationship: positively_regulates GO:0042412 ! taurine biosynthetic process

[Term]
id: GO:0062091
name: Ycf2/FtsHi complex
namespace: cellular_component
def: "A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma." [PMID:30309901]
synonym: "TIC complex associated chloroplast protein import motor" EXACT []
is_a: GO:1904949 ! ATPase complex

[Term]
id: GO:0062092
name: Yae1-Lto1 complex
namespace: cellular_component
def: "A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p." [PMID:26182403]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0062093
name: lysophagy
namespace: biological_process
def: "The selective autophagy process in which a damaged lysosome is degraded by macroautophagy." [PMID:28743755]
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0062094
name: stomach development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ." [PMID:11967278]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0062095
name: endoplasmic reticulum-peroxisome tethering
namespace: biological_process
def: "The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:28463579]
is_a: GO:0060151 ! peroxisome localization
is_a: GO:0140056 ! organelle localization by membrane tethering

[Term]
id: GO:0062096
name: kinetochore disassembly
namespace: biological_process
def: "The disaggregation of a kinetochore into its constituent components." [GOC:mah, PMID:27611693]
is_a: GO:0051383 ! kinetochore organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0062097
name: chemosynthesis
namespace: biological_process
def: "The cellular metabolic process in which organic chemical compounds are synthesized from carbon-containing molecules and nutrients using energy obtained from the oxidation of inorganic compounds or methane." [PMID:25050523]
xref: Wikipedia:Chemosynthesis
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0062098
name: regulation of programmed necrotic cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785]
is_a: GO:0043067 ! regulation of programmed cell death
relationship: regulates GO:0097300 ! programmed necrotic cell death

[Term]
id: GO:0062099
name: negative regulation of programmed necrotic cell death
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0062098 ! regulation of programmed necrotic cell death
relationship: negatively_regulates GO:0097300 ! programmed necrotic cell death

[Term]
id: GO:0062100
name: positive regulation of programmed necrotic cell death
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785]
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0062098 ! regulation of programmed necrotic cell death
relationship: positively_regulates GO:0097300 ! programmed necrotic cell death

[Term]
id: GO:0062101
name: peptidyl-aspartic acid 3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0004597
def: "Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2." [PMID:1378441, PMID:1856229, RHEA:11508]
synonym: "aspartate beta-hydroxylase activity" RELATED [EC:1.14.11.16]
synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16]
synonym: "aspartylpeptide beta-dioxygenase activity" RELATED [EC:1.14.11.16]
synonym: "peptide-aspartate beta-dioxygenase activity" EXACT []
synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.16]
xref: EC:1.14.11.16
xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN
xref: Reactome:R-HSA-9631355 "ASPH:Fe2+ hydroxylates an aspartate residue of F9"
xref: RHEA:11508
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0062102
name: female germline stem cell symmetric division
namespace: biological_process
def: "Division of a female germline stem cell to produce two germline stem cells of the same type as the parent." [GOC:ha, PMID:30248087]
is_a: GO:0098729 ! germline stem cell symmetric division

[Term]
id: GO:0062104
name: pumilio-response element binding
namespace: molecular_function
def: "Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA." [PMID:30601114]
synonym: "PRE binding" EXACT [PMID:30601114]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0062105
name: RNA 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide." [PMID:30626973, RHEA:58956]
xref: RHEA:58956
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008173 ! RNA methyltransferase activity

[Term]
id: GO:0062107
name: regulation of protein localization to non-growing cell tip
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to a non-growing cell tip." [PMID:18328707]
is_a: GO:1903066 ! regulation of protein localization to cell tip
relationship: regulates GO:1902487 ! protein localization to non-growing cell tip

[Term]
id: GO:0062108
name: negative regulation of protein localization to non-growing cell tip
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a non-growing cell tip." [PMID:18328707]
is_a: GO:0062107 ! regulation of protein localization to non-growing cell tip
is_a: GO:1903067 ! negative regulation of protein localization to cell tip
relationship: negatively_regulates GO:1902487 ! protein localization to non-growing cell tip

[Term]
id: GO:0062109
name: regulation of DNA recombinase disassembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of DNA recombinase disassembly, the disaggregation of a DNA recombinase complex into its constituent components." [PMID:30297419]
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
relationship: regulates GO:1990986 ! DNA recombinase disassembly

[Term]
id: GO:0062110
name: negative regulation of DNA recombinase disassembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombinase complex disassembly, the disaggregation of a DNA recombinase complex into its constituent components." [PMID:30297419]
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
is_a: GO:0062109 ! regulation of DNA recombinase disassembly
relationship: negatively_regulates GO:1990986 ! DNA recombinase disassembly

[Term]
id: GO:0062111
name: zinc ion import into organelle
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into the organelle." [PMID:29529046]
is_a: GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0062112
name: fatty acid primary amide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a fatty acid primary amide." [PMID:10079066, PMID:15952893]
synonym: "FAPA biosynthesis" EXACT []
synonym: "FAPA biosynthetic process" EXACT []
synonym: "fatty acid amide biosynthesis" EXACT []
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0062126 ! fatty acid primary amide metabolic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process

[Term]
id: GO:0062113
name: early phagosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an early phagosome." [PMID:18813294]
synonym: "early phagocytic vesicle lumen" EXACT []
is_a: GO:0097013 ! phagocytic vesicle lumen
relationship: part_of GO:0032009 ! early phagosome

[Term]
id: GO:0062116
name: phenyloplast
namespace: cellular_component
def: "A chloroplast-derived plastid in which the solid form of phenol is stored." [PMID:24683183]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0062119
name: LinE complex
namespace: cellular_component
def: "A protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins." [PMID:30640914]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0062120
name: LinE complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components during meiotic prophase to form a LinE complex, the protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins." [PMID:30640914]
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0030999 ! linear element assembly

[Term]
id: GO:0062121
name: linear element maturation
namespace: biological_process
def: "The meiotic cell cycle chromosome organization process in which LinE complexes closely associate with chromatin during meiotic prophase to form mature linear elements." [PMID:30640914]
synonym: "LinE chromosome loading" EXACT [GOC:mah]
synonym: "LinE focus formation" EXACT [GOC:mah]
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
relationship: part_of GO:0030999 ! linear element assembly

[Term]
id: GO:0062122
name: histone H3K37 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group to the lysine residue at position 37 of the histone H3 protein." [PMID:30773398]
synonym: "histone H3K37 methylase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K37 specific)" EXACT []
synonym: "histone methyltransferase activity (H3-K37 specific)" EXACT []
synonym: "histone-H3K37 methyltransferase activity" EXACT []
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0062123
name: regulation of linear element maturation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of linear element maturation." [PMID:30640914]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0090006 ! regulation of linear element assembly
relationship: regulates GO:0062121 ! linear element maturation

[Term]
id: GO:0062124
name: 4-hydroxybutyrate receptor activity
namespace: molecular_function
def: "Combining with 4-hydroxybutyrte to initiate a change in cell activity." [PMID:17197387]
synonym: "gamma-hydroxybutyrate receptor activity" EXACT [PMID:17197387]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0062125
name: regulation of mitochondrial gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [PMID:28285835]
is_a: GO:0010468 ! regulation of gene expression
relationship: regulates GO:0140053 ! mitochondrial gene expression

[Term]
id: GO:0062126
name: fatty acid primary amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform primary fatty amides." [PMID:11128635]
synonym: "primary fatty amide metabolic process" EXACT []
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:0062127
name: fatty acid primary amide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of primary fatty amides." [PMID:11128635]
synonym: "primary fatty amide catabolic process" EXACT []
is_a: GO:0062126 ! fatty acid primary amide metabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process

[Term]
id: GO:0062128
name: MutSgamma complex
namespace: cellular_component
def: "A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5." [PMID:27648641, PMID:7622037, PMID:8001134, PMID:9374523]
synonym: "Msh4-Msh5 complex" NARROW []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0062129
name: chitin-based extracellular matrix
namespace: cellular_component
def: "Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet." [PMID:23955854]
synonym: "chitin-based ECM" EXACT [GOC:dph]
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0062130
name: adhesive extracellular matrix
namespace: cellular_component
def: "A extracellular matrix which attaches an organism to a substrate." [GOC:dph, GOC:ha, PMID:825230]
synonym: "puparial glue" NARROW [GOC:ha]
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0062131
name: 3-butenylglucosinolate 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O." [PMID:18945935]
synonym: "But-3-enyl Glucosinolate-2-hydroxylase activity" EXACT []
xref: MetaCyc:RXNQT-4343
xref: RHEA:60628
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0062132
name: regulation of L-glutamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423]
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:1901704 ! L-glutamine biosynthetic process

[Term]
id: GO:0062133
name: negative regulation of L-glutamine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0062132 ! regulation of L-glutamine biosynthetic process
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:1901704 ! L-glutamine biosynthetic process

[Term]
id: GO:0062134
name: positive regulation of L-glutamine biosynthetic process
namespace: biological_process
def: "Any process that starts, increases the frequency, rate or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0062132 ! regulation of L-glutamine biosynthetic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
relationship: positively_regulates GO:1901704 ! L-glutamine biosynthetic process

[Term]
id: GO:0062136
name: low-density lipoprotein receptor complex
namespace: cellular_component
def: "A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors." [GOC:bhm, PMID:26005850]
synonym: "LDL receptor complex" EXACT [GOC:dph]
synonym: "LDLR complex" EXACT [GOC:dph]
synonym: "low-density lipoprotein particle receptor complex" EXACT [GOC:dph]
is_a: GO:0062137 ! cargo receptor complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0062137
name: cargo receptor complex
namespace: cellular_component
def: "Any protein complex that is part of a membrane and which functions as a cargo receptor." [PMID:27903609]
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0062139
name: camera-type eye photoreceptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a light-responsive receptor in a camera-type eye over time, from its formation to the mature structure." [PMID:20648062, PMID:30237290]
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0062140
name: hyphae septin collar
namespace: cellular_component
def: "A septin collar in pathogenic fungi involved in the constriction of hyphae at the plant plasmodesma enabling penetration of an adjacent cell." [PMID:29567712]
synonym: "septin collar of invasive hyphae" RELATED []
is_a: GO:0032173 ! septin collar

[Term]
id: GO:0062141
name: nuclear exosome targeting complex
namespace: cellular_component
def: "A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts." [PMID:21855801, PMID:29844170]
synonym: "NEXT complex" EXACT [PMID:21855801, PMID:29844170]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0062142
name: L-beta-ethynylserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria." [PMID:3082841, PMID:30867596]
is_a: GO:0120237 ! terminal acetylenic compound biosynthetic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0062143
name: L-propargylglycine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria." [PMID:30867596]
is_a: GO:0120237 ! terminal acetylenic compound biosynthetic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process

[Term]
id: GO:0062144
name: L-propargylglycine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H+ + L-propargylglycine." [PMID:30867596, RHEA:59892]
xref: RHEA:59892
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0062145
name: L-propargylglycine--L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H+ + L-gamma-glutamyl-L-propargylglycine + phosphate." [PMID:30867596, RHEA:59896]
xref: RHEA:59896
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0062146
name: 4-chloro-allylglycine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)." [PMID:30867596, RHEA:59888]
xref: RHEA:59888
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0062147
name: L-lysine 4-chlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + chloride + H+ + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate." [PMID:30867596, RHEA:59884]
xref: RHEA:59884
is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

[Term]
id: GO:0062148
name: L-gamma-glutamyl-L-propargylglycine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate." [PMID:30867596, RHEA:59900]
xref: RHEA:59900
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0062149
name: detection of stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031]
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0062150
name: amorpha-4,11-diene 12-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]." [PMID:16458889, PMID:16612385, PMID:23246612, RHEA:32999]
xref: EC:1.14.14.114
xref: RHEA:32999
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0062151
name: catalase complex
namespace: cellular_component
def: "A protein-containing complex that is capable of catalase activity." [GOC:bhm, PMID:10656833]
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0062152
name: mRNA (cytidine-5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine." [PMID:22395603, PMID:23871666, RHEA:61464]
synonym: "mRNA (cytosine-5-)-methyltransferase activity" EXACT []
xref: RHEA:61464
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0062153
name: C5-methylcytidine-containing RNA reader activity
namespace: molecular_function
def: "A protein adaptor that recognizes and binds an RNA molecule modified by C5-methylcytidine." [PMID:28418038]
synonym: "C5-methylcytidine-containing RNA binding" RELATED []
synonym: "C5-methylcytosine-containing RNA binding" RELATED []
is_a: GO:0140517 ! protein-RNA adaptor activity

[Term]
id: GO:0062154
name: N6-methyl-AMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate." [PMID:29884623, RHEA:16001]
synonym: "MAPDA" EXACT [PMID:29884623]
synonym: "N6-mAMP deaminase activity" EXACT []
synonym: "N6-methyl-AMP/dAMP aminohydrolase" EXACT [PMID:21755941]
xref: Reactome:R-HSA-2161187 "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine"
xref: Reactome:R-HSA-2161195 "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine"
xref: Reactome:R-HSA-9731661 "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine"
xref: RHEA:16001
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0062155
name: curli secretion complex
namespace: cellular_component
def: "A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms." [PMID:25219853]
is_a: GO:1902495 ! transmembrane transporter complex
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0062156
name: mitochondrial ATP-gated potassium channel activity
namespace: molecular_function
def: "Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane." [PMID:31435016]
synonym: "mitochondrial potassium channel activity" EXACT []
synonym: "mitoK-ATP activity" EXACT []
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0035381 ! ATP-gated ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0062157
name: mitochondrial ATP-gated potassium channel complex
namespace: cellular_component
def: "A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane." [PMID:31435016]
is_a: GO:0034705 ! potassium channel complex

[Term]
id: GO:0062158
name: chloride:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out)." [PMID:14985752]
is_a: GO:0005452 ! solute:inorganic anion antiporter activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0062159
name: contractile vacuole complex
namespace: cellular_component
def: "A non-membrane-bounded organelle of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally. One of its functions is osmoregulatory." [PMID:23890380]
synonym: "CVC" RELATED [PMID:23890380]
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0062160
name: spongiome
namespace: cellular_component
def: "A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory." [PMID:23890380]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0062159 ! contractile vacuole complex

[Term]
id: GO:0062161
name: regulation of pyocyanine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a pyocyanine biosynthetic process." [PMID:28715477]
synonym: "regulation of pyocyanin biosynthetic process" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0106220 ! pyocyanine biosynthetic process

[Term]
id: GO:0062162
name: positive regulation of pyocyanine biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a pyocyanine biosynthetic process." [PMID:28715477]
synonym: "positive regulation of pyocyanin biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0062161 ! regulation of pyocyanine biosynthetic process
relationship: positively_regulates GO:0106220 ! pyocyanine biosynthetic process

[Term]
id: GO:0062163
name: pseudohyphal septin ring assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of septins and associated proteins to form a tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection." [PMID:29567712]
is_a: GO:0000921 ! septin ring assembly

[Term]
id: GO:0062164
name: regulation of pseudohyphal septin ring assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pseudohyphal septin ring assembly." [PMID:29567712]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0051493 ! regulation of cytoskeleton organization
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0062163 ! pseudohyphal septin ring assembly

[Term]
id: GO:0062165
name: positive regulation of pseudohyphal septin ring assembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of pseudohyphal septin ring formation." [PMID:29567712]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0062164 ! regulation of pseudohyphal septin ring assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0062163 ! pseudohyphal septin ring assembly

[Term]
id: GO:0062166
name: negative regulation of pseudohyphal septin ring assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of pseudohyphal septin ring assembly." [PMID:29567712]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0062164 ! regulation of pseudohyphal septin ring assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0062163 ! pseudohyphal septin ring assembly

[Term]
id: GO:0062167
name: complement component C1q complex
namespace: cellular_component
def: "A protein-containing complex composed of six subunits of each of the three homologous polypeptide chains C1QA, C1QB, and C1QB. It is a subunit of the complement C1 complex. In addition to complement activation, C1q appears to have roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning." [PMID:29449492]
synonym: "C1q" EXACT []
synonym: "Complement 1q" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0062168
name: negative regulation of plus-end directed microtubule sliding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plus-end directed microtubule sliding." [PMID:21892183]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0062169 ! regulation of plus-end directed microtubule sliding
relationship: negatively_regulates GO:0031535 ! plus-end directed microtubule sliding

[Term]
id: GO:0062169
name: regulation of plus-end directed microtubule sliding
namespace: biological_process
def: "Any process that mediates the frequency, rate, or extent of plus-end directed microtubule sliding." [PMID:21892183]
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0031535 ! plus-end directed microtubule sliding

[Term]
id: GO:0062170
name: lutein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform lutein." [PMID:24397433]
synonym: "lutein metabolism" EXACT []
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0062171
name: lutein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lutein." [PMID:24397433]
synonym: "lutein anabolism" EXACT []
synonym: "lutein biosynthesis" EXACT []
synonym: "lutein formation" EXACT []
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:0062170 ! lutein metabolic process

[Term]
id: GO:0062172
name: lutein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lutein." [PMID:24397433]
synonym: "lutein breakdown" EXACT []
synonym: "lutein catabolism" EXACT []
synonym: "lutein degradation" EXACT []
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:0062170 ! lutein metabolic process

[Term]
id: GO:0062173
name: brexanolone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which living organisms transform brexanolone." [PMID:24390875]
synonym: "allopregnanolone metabolic process" EXACT []
synonym: "allopregnanolone metabolism" EXACT []
synonym: "allotetrahydroprogesterone metabolic process" EXACT []
synonym: "allotetrahydroprogesterone metabolism" EXACT []
synonym: "brexanolone metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0062174
name: brexanolone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of brexanolone." [PMID:24390875]
synonym: "allopregnanolone anabolism" EXACT []
synonym: "allopregnanolone biosynthesis" EXACT []
synonym: "allopregnanolone biosynthetic process" EXACT []
synonym: "allopregnanolone synthesis" EXACT []
synonym: "allotetrahydroprogesterone anabolism" EXACT []
synonym: "allotetrahydroprogesterone biosynthesis" EXACT []
synonym: "allotetrahydroprogesterone biosynthetic process" EXACT []
synonym: "allotetrahydroprogesterone synthesis" EXACT []
synonym: "brexanolone anabolism" EXACT []
synonym: "brexanolone biosynthesis" EXACT []
synonym: "brexanolone synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0062173 ! brexanolone metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0062175
name: brexanolone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of brexanolone." [PMID:24390875]
synonym: "allopregnanolone breakdown" EXACT []
synonym: "allopregnanolone catabolic process" EXACT []
synonym: "allopregnanolone catabolism" EXACT []
synonym: "allopregnanolone degradation" EXACT []
synonym: "allotetrahydroprogesterone breakdown" EXACT []
synonym: "allotetrahydroprogesterone catabolic process" EXACT []
synonym: "allotetrahydroprogesterone catabolism" EXACT []
synonym: "allotetrahydroprogesterone degradation" EXACT []
synonym: "brexanolone breakdown" EXACT []
synonym: "brexanolone catabolism" EXACT []
synonym: "brexanolone degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0062173 ! brexanolone metabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0062176
name: R-loop processing
namespace: biological_process
def: "A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability." [PMID:27252122, PMID:28790157, PMID:33986538]
synonym: "R-loop disassembly" EXACT []
is_a: GO:0006338 ! chromatin remodeling

[Term]
id: GO:0062177
name: radial spoke assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules." [PMID:21613541, PMID:21692193, PMID:24124175, PMID:27940518, PMID:8408197]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0035082 ! axoneme assembly

[Term]
id: GO:0062179
name: vitamin D 23-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-23 of any form of vitamin D." [PMID:22100522, PMID:30205156]
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0062180
name: 25-hydroxycholecalciferol-23-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]." [PMID:22100522, PMID:30205156, RHEA:46616]
xref: RHEA:46616
is_a: GO:0062179 ! vitamin D 23-hydroxylase activity

[Term]
id: GO:0062181
name: 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
namespace: molecular_function
def: "Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]." [PMID:22100522, PMID:30205156, RHEA:49192]
xref: RHEA:49192
is_a: GO:0062179 ! vitamin D 23-hydroxylase activity

[Term]
id: GO:0062182
name: all-trans retinoic acid 4-hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:9250660, PMID:9716180, RHEA:51492]
xref: RHEA:51492
is_a: GO:0008401 ! retinoic acid 4-hydroxylase activity

[Term]
id: GO:0062183
name: all-trans retinoic acid 18-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:22020119, RHEA:55856]
xref: RHEA:55856
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0062184
name: testosterone 16-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:46304]
xref: RHEA:46304
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0062185
name: secalciferol 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction:2 H+ + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]." [PMID:10518789, RHEA:49064]
xref: RHEA:49064
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0062186
name: anandamide epoxidase activity
namespace: molecular_function
def: "Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide." [PMID:21289075]
synonym: "arachidonoylethanolamide epoxidase activity" EXACT [PMID:21289075]
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0062187
name: anandamide 8,9 epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53140]
xref: RHEA:53140
is_a: GO:0062186 ! anandamide epoxidase activity

[Term]
id: GO:0062188
name: anandamide 11,12 epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53144]
xref: RHEA:53144
is_a: GO:0062186 ! anandamide epoxidase activity

[Term]
id: GO:0062189
name: anandamide 14,15 epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53148]
xref: RHEA:53148
is_a: GO:0062186 ! anandamide epoxidase activity

[Term]
id: GO:0062191
name: galactoxylomannan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals." [PMID:16441437, PMID:18952901, PMID:19684080, PMID:21843086]
synonym: "galactoxylomannan anabolism" EXACT []
synonym: "galactoxylomannan biosynthesis" EXACT []
synonym: "galactoxylomannan formation" EXACT []
synonym: "galactoxylomannan synthesis" EXACT []
synonym: "GalXM biosynthetic process" EXACT []
synonym: "glucuronoxylomannogalactan biosynthetic process" EXACT []
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process

[Term]
id: GO:0062192
name: L-rhamnose mutarotase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose." [RHEA:25584]
xref: EC:5.1.3.32
xref: RHEA:25584
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0062193
name: D-ribose pyranase activity
namespace: molecular_function
def: "Catalysis of the reactions: beta-D-ribopyranose = beta-D-ribofuranose, and beta-allofuranose = beta-allopyranose." [EC:5.4.99.62]
xref: EC:5.4.99.62
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0062194
name: cytoplasmic microtubule minus-end
namespace: cellular_component
def: "A microtubule minus end that is part of a cytoplasmic microtubule." [PMID:18061564]
is_a: GO:0036449 ! microtubule minus-end
relationship: part_of GO:0005881 ! cytoplasmic microtubule

[Term]
id: GO:0062195
name: microtubule bundle maintenance
namespace: biological_process
def: "The organization process that preserves a microtubule bundle in a stable functional or structural state." [PMID:18061564]
is_a: GO:0043954 ! cellular component maintenance

[Term]
id: GO:0062196
name: regulation of lysosome size
namespace: biological_process
def: "Any process that modulates the size of a lysosome." [PMID:31314175]
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0062197
name: cellular response to chemical stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0062198
name: obsolete rDNA replication pause site heterochromatin
namespace: cellular_component
def: "OBSOLETE. A region of heterochromatin associated with sites in rDNA repeats where replication forks pause." [PMID:25417108]
comment: This term was obsoleted because it does not represent a specific cellular component.
is_obsolete: true

[Term]
id: GO:0062200
name: RAM/MOR signaling
namespace: biological_process
def: "An intracellular signaling cascade that starts with the activation of S. cerevisiae Kic1p, which activate Mob2p and Cbk1p. Cbk1p phosphorylates Ace2p, which results in its nuclear translocation, where it regulates transcription of genes involved in polarity and morphogenesis." [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372, PMID:23212898]
synonym: "MOR signaling pathway" NARROW []
synonym: "morphogenesis Orb6 network" EXACT []
synonym: "RAM signaling pathway" NARROW []
synonym: "RAM/MOR signaling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0062201
name: actin wave
namespace: cellular_component
def: "A cellular anatomical entity that is part of the actin cytoskeleton and results in a wave-like propagation of actin networks. It consists of dynamic structures traveling on the ventral (substrate-attached) side of the cell during cell migration, cytokinesis, adhesion and neurogenesis." [PMID:26190109, PMID:31230946, PMID:31390543, PMID:31678045, PMID:31774725]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0062202
name: Labd-13(16),14-diene-9-ol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol." [PMID:29315936, RHEA:62184]
xref: RHEA:62184
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0062203
name: Viteagnusin D synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D." [PMID:29315936, RHEA:62180]
xref: RHEA:62180
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0062204
name: (13S)-vitexifolin A synthase activity
namespace: molecular_function
def: "Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate." [PMID:29315936, RHEA:40027]
xref: RHEA:40027
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0062205
name: miltiradiene synthase activity
namespace: molecular_function
alt_id: GO:0102353
def: "Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene." [PMID:24990389, RHEA:33983]
synonym: "multiradiene synthase activity" RELATED []
xref: EC:4.2.3.131
xref: MetaCyc:RXN-13338
xref: RHEA:33983
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0062206
name: manoyl oxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate." [PMID:24990389, RHEA:54516]
xref: EC:4.2.3.190
xref: RHEA:54516
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0062207
name: regulation of pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0062208
name: positive regulation of pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: positively_regulates GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0062209
name: spatial regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
namespace: biological_process
def: "Any process that modulates the distribution of sites along the chromosome where meiotic DNA double-strand break formation takes place as part of reciprocal meiotic recombination." [PMID:25324213, PMID:30217891]
synonym: "crossover interference" RELATED [PMID:30217891]
synonym: "DSB interference" RELATED []
synonym: "regulation of spatial distribution of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT []
synonym: "regulation of spatial distribution of meiotic DSB formation involved in reciprocal meiotic recombination" EXACT []
is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

[Term]
id: GO:0062210
name: shoot regeneration
namespace: biological_process
def: "The regeneration process by which a damaged or lost shoot regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to produce a new shoot meristem and subsequently a new shoot." [PMID:27143753]
synonym: "shoot system regeneration" EXACT []
is_a: GO:0031099 ! regeneration
is_a: GO:0048367 ! shoot system development

[Term]
id: GO:0062211
name: root regeneration
namespace: biological_process
def: "The the regeneration process by which a damaged or lost root regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to form a new root meristem and subsequently new root." [PMID:27143753]
is_a: GO:0031099 ! regeneration
is_a: GO:0048364 ! root development

[Term]
id: GO:0062212
name: regulation of mitotic DNA replication initiation from early origin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of firing from an early origin of replication involved in mitotic DNA replication." [PMID:22279046]
synonym: "regulation of early replication origin firing" EXACT []
is_a: GO:1903466 ! regulation of mitotic DNA replication initiation

[Term]
id: GO:0062213
name: peroxynitrite isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: peroxynitrite = nitrate." [PMID:30524950, RHEA:63116]
xref: RHEA:63116
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0062223
name: regulation of somatic muscle development
namespace: biological_process
def: "Any process that regulates the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0007525 ! somatic muscle development

[Term]
id: GO:0062224
name: positive regulation of somatic muscle development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0062223 ! regulation of somatic muscle development
relationship: positively_regulates GO:0007525 ! somatic muscle development

[Term]
id: GO:0062225
name: negative regulation of somatic muscle development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0062223 ! regulation of somatic muscle development
relationship: negatively_regulates GO:0007525 ! somatic muscle development

[Term]
id: GO:0062226
name: regulation of adult somatic muscle development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of adult somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0062223 ! regulation of somatic muscle development
relationship: regulates GO:0007527 ! adult somatic muscle development

[Term]
id: GO:0062227
name: positive regulation of adult somatic muscle development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of adult somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0062224 ! positive regulation of somatic muscle development
is_a: GO:0062226 ! regulation of adult somatic muscle development
relationship: positively_regulates GO:0007527 ! adult somatic muscle development

[Term]
id: GO:0062228
name: negative regulation of adult somatic muscle development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of adult somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0062225 ! negative regulation of somatic muscle development
is_a: GO:0062226 ! regulation of adult somatic muscle development
relationship: negatively_regulates GO:0007527 ! adult somatic muscle development

[Term]
id: GO:0062229
name: regulation of larval somatic muscle development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of larval somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0062223 ! regulation of somatic muscle development
relationship: regulates GO:0007526 ! larval somatic muscle development

[Term]
id: GO:0062230
name: negative regulation of larval somatic muscle development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of larval somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0062225 ! negative regulation of somatic muscle development
is_a: GO:0062229 ! regulation of larval somatic muscle development
relationship: negatively_regulates GO:0007526 ! larval somatic muscle development

[Term]
id: GO:0062231
name: positive regulation of larval somatic muscle development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of larval somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0062224 ! positive regulation of somatic muscle development
is_a: GO:0062229 ! regulation of larval somatic muscle development
relationship: positively_regulates GO:0007526 ! larval somatic muscle development

[Term]
id: GO:0062232
name: prostanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prostanoids." [PMID:25449649]
is_a: GO:1901523 ! icosanoid catabolic process

[Term]
id: GO:0062233
name: F2-isoprostane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of F2-isoprostane." [PMID:16371369, PMID:25449649]
is_a: GO:1901523 ! icosanoid catabolic process

[Term]
id: GO:0062234
name: platelet activating factor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine." [PMID:16371369]
synonym: "2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine catabolic process" EXACT []
synonym: "PAF catabolic process" RELATED []
is_a: GO:0044269 ! glycerol ether catabolic process
is_a: GO:0046469 ! platelet activating factor metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0062235
name: axonemal basal plate assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal basal plate." [PMID:23352055, PMID:30810527]
synonym: "axonemal basal plate formation" NARROW []
synonym: "axoneme basal plate assembly" EXACT []
synonym: "basal plate assembly" BROAD []
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0035082 ! axoneme assembly

[Term]
id: GO:0062236
name: ionocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an ionocyte. Ionocytes are specialized epithelial cells that contribute to osmotic homeostasis." [PMID:17555741]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0062237
name: protein localization to postsynapse
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell." [PMID:31189538]
is_a: GO:0035418 ! protein localization to synapse

[Term]
id: GO:0062238
name: Smp focus
namespace: cellular_component
def: "A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I." [PMID:22582262, PMID:31811152]
synonym: "Smp dot" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0062239
name: heterochromatin-nuclear membrane anchor activity
namespace: molecular_function
def: "Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization." [PMID:31635174]
synonym: "heterochromatin-nuclear membrane tether activity" EXACT []
synonym: "nuclear membrane-heterochromatin anchor activity" EXACT []
synonym: "nuclear membrane-heterochromatin tether activity" EXACT []
is_a: GO:0140707 ! chromatin-nuclear membrane anchor activity

[Term]
id: GO:0062240
name: euchromatin-nuclear membrane anchor activity
namespace: molecular_function
def: "Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization." [PMID:31635174]
synonym: "euchromatin-nuclear membrane tether activity" EXACT []
synonym: "nuclear membrane-euchromatin anchor activity" EXACT []
synonym: "nuclear membrane-euchromatin tether activity" EXACT []
is_a: GO:0140707 ! chromatin-nuclear membrane anchor activity

[Term]
id: GO:0062241
name: double strand break-nuclear membrane anchor activity
namespace: molecular_function
def: "Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair." [PMID:31635174]
synonym: "DNA repair factory" RELATED []
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0062242
name: double membrane vesicle viral factory membrane
namespace: cellular_component
def: "One of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory." [PMID:22440839]
synonym: "membrane of double membrane vesicle viral factory" EXACT []
is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane
relationship: part_of GO:0039718 ! double membrane vesicle viral factory

[Term]
id: GO:0062243
name: double membrane vesicle viral factory outer membrane
namespace: cellular_component
def: "The outer of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory." [PMID:22440839]
synonym: "outer membrane of double membrane vesicle viral factory" EXACT []
is_a: GO:0062242 ! double membrane vesicle viral factory membrane

[Term]
id: GO:0062244
name: double membrane vesicle viral factory lumen
namespace: cellular_component
def: "The volume surrounded by the inner membrane of a double membrane vesicle viral factory." [PMID:22440839]
synonym: "lumen of double membrane vesicle viral factory" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0039718 ! double membrane vesicle viral factory

[Term]
id: GO:0062245
name: double membrane vesicle viral factory inner membrane
namespace: cellular_component
def: "The inner of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory." [PMID:22440839]
synonym: "inner membrane of double membrane vesicle viral factory" EXACT []
is_a: GO:0062242 ! double membrane vesicle viral factory membrane

[Term]
id: GO:0062246
name: exocytic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by an exocytic vesicle." [PMID:27384577]
is_a: GO:0098566 ! transport vesicle lumen
relationship: part_of GO:0070382 ! exocytic vesicle

[Term]
id: GO:0062247
name: chloroplast vesicle
namespace: cellular_component
def: "A intracellular vesicle that is part of a chloroplast." [PMID:32245810]
is_a: GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0062248
name: cleistothecium formation
namespace: biological_process
def: "The process of producing a cleistothecium, a closed sexual fruiting body that contains ascospores in linear asci. Cleistothecia are present in some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [PMID:20348388, PMID:28889020, PMID:30410052]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0070791 ! cleistothecium development

[Term]
id: GO:0065001
name: specification of axis polarity
namespace: biological_process
def: "The pattern specification process in which the polarity of a body or organ axis is established and maintained." [GOC:mah]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0009798 ! axis specification

[Term]
id: GO:0065002
name: intracellular protein transmembrane transport
namespace: biological_process
def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "intracellular membrane translocation of a protein" EXACT []
synonym: "intracellular protein membrane transport" EXACT []
synonym: "intracellular protein transport across a membrane" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0065003
name: protein-containing complex assembly
namespace: biological_process
alt_id: GO:0006461
alt_id: GO:0034622
alt_id: GO:0043623
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular macromolecule complex assembly" RELATED []
synonym: "cellular protein complex assembly" EXACT []
synonym: "cellular protein-containing complex assembly" RELATED []
synonym: "chaperone activity" RELATED []
synonym: "macromolecular complex assembly" RELATED []
synonym: "macromolecule complex assembly" RELATED []
synonym: "protein complex assembly" RELATED []
synonym: "protein complex formation" RELATED []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0065004
name: protein-DNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]
synonym: "DNA-protein complex assembly" EXACT [GOC:mah]
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0071824 ! protein-DNA complex organization

[Term]
id: GO:0065005
name: protein-lipid complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl]
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0071825 ! protein-lipid complex organization

[Term]
id: GO:0065007
name: biological regulation
namespace: biological_process
def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "regulation" BROAD []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0065008
name: regulation of biological quality
namespace: biological_process
def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: goslim_pir
synonym: "regulation of biological attribute" EXACT []
synonym: "regulation of biological characteristic" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0065009
name: regulation of molecular function
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]
subset: gocheck_obsoletion_candidate
subset: goslim_pir
subset: goslim_plant
synonym: "regulation of a molecular function" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0065010
name: extracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]
synonym: "extracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0070001
name: aspartic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070002
name: glutamic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070003
name: threonine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070004
name: cysteine-type exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0070005
name: cysteine-type aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0070004 ! cysteine-type exopeptidase activity

[Term]
id: GO:0070006
name: metalloaminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0008235 ! metalloexopeptidase activity

[Term]
id: GO:0070007
name: glutamic-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070002 ! glutamic-type peptidase activity

[Term]
id: GO:0070008
name: serine-type exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]
is_a: GO:0008236 ! serine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0070009
name: serine-type aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity

[Term]
id: GO:0070012
name: oligopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732]
is_a: GO:0004175 ! endopeptidase activity

[Term]
id: GO:0070013
name: intracellular organelle lumen
namespace: cellular_component
def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0070014
name: sucrase-isomaltase complex
namespace: cellular_component
def: "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities." [PMID:3366777]
synonym: "oligo-1,6-glucosidase complex" RELATED []
xref: Wikipedia:Sucrase-isomaltase
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902687 ! glucosidase complex

[Term]
id: GO:0070016
name: armadillo repeat domain binding
namespace: molecular_function
def: "Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation." [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225]
synonym: "Arm repeat domain binding" EXACT []
synonym: "armadillo domain binding" EXACT []
synonym: "armadillo repeat binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070017
name: alphav-beta3 integrin-thrombospondin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin." [PMID:2478219]
synonym: "ITGAV-ITGB3-THBS1 complex" NARROW [CORUM:2846]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070018
name: obsolete transforming growth factor beta type I receptor homodimeric complex
namespace: cellular_component
def: "OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers." [GOC:curators]
comment: This term was made obsolete because it does not represent a physiological complex.
synonym: "TGF-beta type I receptor complex" EXACT []
synonym: "TGF-beta type I receptor dimer" EXACT []
synonym: "TGFBR1 homodimer" EXACT []
synonym: "transforming growth factor beta type I receptor complex" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0070019
name: obsolete transforming growth factor beta type II receptor homodimeric complex
namespace: cellular_component
def: "OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers." [GOC:curators]
comment: This term was made obsolete because it does not represent a physiological complex.
synonym: "TGF-beta type II receptor complex" EXACT []
synonym: "TGF-beta type II receptor dimer" EXACT []
synonym: "TGFBR2 homodimer" EXACT []
synonym: "transforming growth factor beta type II receptor complex" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0070020
name: obsolete transforming growth factor beta1-type II receptor complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [GOC:curators]
comment: This term was made obsolete because it does not represent a physiological complex.
synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT []
synonym: "TGF-beta1-type II receptor complex" EXACT []
is_obsolete: true

[Term]
id: GO:0070021
name: transforming growth factor beta ligand-receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand." [GOC:curators]
synonym: "TGF-beta 1:type II receptor:type I receptor complex" NARROW []
synonym: "TGF-beta ligand-receptor complex" EXACT []
synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" NARROW []
synonym: "TGF-beta1 ligand-receptor complex" NARROW []
synonym: "TGF-beta1-beta2 ligand-receptor complex" NARROW []
synonym: "TGF-beta1-type II receptor-type I receptor complex" NARROW []
synonym: "TGF-beta2 ligand-receptor complex" NARROW []
synonym: "TGFb ligand-receptor complex" EXACT []
synonym: "TGFbeta ligand-receptor complex" EXACT []
synonym: "TGFbeta1 ligand-receptor complex" NARROW []
synonym: "TGFbeta1-beta2 ligand-receptor complex" NARROW []
synonym: "TGFbeta2 ligand-receptor complex" NARROW []
synonym: "transforming growth factor beta1-type II receptor-type I receptor complex" NARROW []
is_a: GO:0098802 ! plasma membrane signaling receptor complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0070022
name: obsolete transforming growth factor beta receptor complex
namespace: cellular_component
def: "OBSOLETE. A homodimeric receptor complex that consists of two TGF-beta receptor monomers." [GOC:mah]
comment: This term was made obsolete because it does not represent a physiological complex.
synonym: "TGF-beta receptor complex" BROAD []
synonym: "transforming growth factor beta receptor complex" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0070023
name: interleukin-12-interleukin-12 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991]
synonym: "IL12-IL12 receptor complex" EXACT []
synonym: "IL12B-IL12RB1-IL12RB2 complex" NARROW [CORUM:2020]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070024
name: CD19-Vav-PIK3R1 complex
namespace: cellular_component
def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218]
synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070025
name: carbon monoxide binding
namespace: molecular_function
def: "Binding to carbon monoxide (CO)." [GOC:ecd]
synonym: "CO binding" EXACT []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0070026
name: nitric oxide binding
namespace: molecular_function
def: "Binding to nitric oxide (NO)." [GOC:ecd]
synonym: "nitrogen monoxide binding" EXACT []
synonym: "nitrosyl binding" EXACT [CHEBI:16480]
synonym: "NO binding" EXACT []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0070027
name: carbon monoxide sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)." [GOC:ecd]
synonym: "carbon monoxide sensing activity" EXACT []
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0070028
name: obsolete regulation of transcription by carbon monoxide
namespace: biological_process
def: "OBSOLETE. Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription." [GOC:ecd]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of transcription by CO" EXACT []
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:0070029
name: alphav-beta3 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin." [PMID:7532190]
synonym: "ITGAV-ITGB3-SPP1 complex" NARROW [CORUM:2358]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070030
name: alphav-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin." [PMID:7592829]
synonym: "ITGAV-ITGB1-SPP1 complex" NARROW [CORUM:2885]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070031
name: alphav-beta5 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin." [PMID:7592829]
synonym: "ITGAV-ITGB5-SPP1 complex" NARROW [CORUM:2347]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070032
name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof)." [PMID:7553862]
synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)" NARROW [CORUM:795]
synonym: "Vamp2-Snap25-Stx1a-Cplx1 complex" NARROW [CORUM:795]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070033
name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof)." [PMID:7553862]
synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)" NARROW [CORUM:796]
synonym: "Vamp2-Snap25-Stx1a-Cplx2 complex" NARROW [CORUM:796]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070034
name: telomerase RNA binding
namespace: molecular_function
def: "Binding to the telomerase RNA template." [GOC:krc, PMID:16884717]
synonym: "TERC binding" RELATED [GOC:dph]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0070035
name: obsolete purine NTP-dependent helicase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah]
comment: The reason for obsoletion is that helicases only and always use ATP (although under very specific experimental conditions GTP can perhaps be used; this is not the case in vivo), therefore this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0070036
name: obsolete GTP-dependent helicase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah]
comment: The reason for obsoletion is that helicases only and always use ATP (although under very specific experimental conditions GTP can perhaps be used; this is not the case in vivo).
is_obsolete: true

[Term]
id: GO:0070037
name: rRNA (pseudouridine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah]
xref: Reactome:R-HSA-6790906 "EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248"
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0070038
name: rRNA (pseudouridine-N3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine." [GOC:imk, GOC:mah]
is_a: GO:0070037 ! rRNA (pseudouridine) methyltransferase activity

[Term]
id: GO:0070039
name: rRNA (guanosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine." [GOC:imk, GOC:mah]
xref: Reactome:R-HSA-6793096 "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370"
xref: Reactome:R-HSA-6793122 "MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145"
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity
is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity

[Term]
id: GO:0070040
name: rRNA (adenine(2503)-C2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine." [GOC:imk, PMID:20007606, PMID:20184321, PMID:21368151, PMID:21415317, PMID:21527678, RHEA:42916]
synonym: "rRNA (adenine-C2-)-methyltransferase activity" BROAD []
xref: MetaCyc:RXN-11586
xref: RHEA:42916
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0070041
name: rRNA (uridine-C5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine." [GOC:imk, GOC:mah]
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0070042
name: rRNA (uridine-N3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine." [GOC:imk, GOC:mah]
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0070043
name: rRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine." [GOC:imk, GOC:mah]
xref: Reactome:R-HSA-6790982 "WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0070044
name: synaptobrevin 2-SNAP-25-syntaxin-1a complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434]
synonym: "Snap25-Stx1a-Vamp2 complex" NARROW []
synonym: "SNARE complex (Snap25, Stx1a, Vamp2)" NARROW [CORUM:998]
synonym: "SNARE complex (Stx1a, SNAP25, VAMP)" NARROW [CORUM:841]
synonym: "Stx1a-SNAP25-VAMP complex" NARROW [CORUM:841]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070045
name: synaptobrevin 2-SNAP-25-syntaxin-2 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx2, Snap25, Vamp2)" NARROW [CORUM:851]
synonym: "Stx2-Snap25-Vamp2 complex" NARROW [CORUM:851]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070046
name: synaptobrevin 2-SNAP-25-syntaxin-3 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx3, Snap25, Vamp2)" NARROW [CORUM:852]
synonym: "Stx3-Snap25-Vamp2 complex" NARROW [CORUM:852]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070047
name: synaptobrevin 2-SNAP-25-syntaxin-4 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx4, Snap25, Vamp2)" NARROW [CORUM:853]
synonym: "Stx4-Snap25-Vamp2 complex" NARROW [CORUM:853]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070048
name: endobrevin-SNAP-25-syntaxin-1a complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx1a, Snap25, Vamp8)" NARROW [CORUM:854]
synonym: "Stx1a-Snap25-Vamp8 complex" NARROW [CORUM:854]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070049
name: endobrevin-SNAP-25-syntaxin-2 complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx2, Snap25, Vamp8)" NARROW [CORUM:855]
synonym: "Stx2-Snap25-Vamp8 complex" NARROW [CORUM:855]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070050
name: neuron cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
synonym: "neuron maintenance" EXACT []
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0070051
name: fibrinogen binding
namespace: molecular_function
def: "Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0070052
name: collagen V binding
namespace: molecular_function
def: "Binding to a type V collagen trimer." [GOC:BHF, GOC:mah]
is_a: GO:0005518 ! collagen binding

[Term]
id: GO:0070053
name: thrombospondin receptor activity
namespace: molecular_function
def: "Combining with thrombospondin and transmitting the signal to initiate a change in cell activity." [GOC:BHF, GOC:signaling, GOC:vk]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0070054
name: mRNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
alt_id: GO:0061012
def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah]
comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
synonym: "cytosolic mRNA splicing" RELATED []
is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0070055
name: obsolete mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "OBSOLETE. The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response." [GOC:bf, GOC:krc, GOC:mah, PMID:10357823]
comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498).
synonym: "ERN1-mediated XBP-1 mRNA cleavage" RELATED [HGNC:3449]
synonym: "HAC1 mRNA cleavage" NARROW [GOC:bf]
synonym: "HAC1-type intron splice site recognition and cleavage" NARROW []
synonym: "IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:bf]
synonym: "XBP1 mRNA cleavage" NARROW [GOC:bf]
is_obsolete: true
consider: GO:0036498

[Term]
id: GO:0070056
name: prospore membrane leading edge
namespace: cellular_component
def: "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization." [GOC:mah, PMID:14702385]
synonym: "forespore membrane leading edge" EXACT []
is_a: GO:0016020 ! membrane
relationship: part_of GO:0005628 ! prospore membrane

[Term]
id: GO:0070057
name: prospore membrane spindle pole body attachment site
namespace: cellular_component
def: "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus." [GOC:mah, PMID:14702385]
synonym: "forespore membrane SPB attachment site" EXACT []
synonym: "forespore membrane spindle pole body attachment site" EXACT []
synonym: "prospore membrane SPB attachment site" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005628 ! prospore membrane

[Term]
id: GO:0070058
name: tRNA gene clustering
namespace: biological_process
def: "The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae." [GOC:jh, GOC:mah, PMID:18708579]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0070059
name: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]
synonym: "apoptosis in response to endoplasmic reticulum stress" BROAD []
synonym: "apoptosis in response to ER stress" EXACT []
synonym: "apoptosis triggered by ER stress" EXACT []
synonym: "endoplasmic reticulum stress-induced apoptosis" EXACT []
synonym: "ER stress-induced apoptosis" EXACT []
synonym: "intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT []
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0070060
name: 'de novo' actin filament nucleation
namespace: biological_process
def: "The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament." [GOC:mah, PMID:17477841]
synonym: "formin-mediated actin filament nucleation" NARROW []
synonym: "unbranched actin filament nucleation" RELATED []
is_a: GO:0045010 ! actin nucleation

[Term]
id: GO:0070061
name: fructose binding
namespace: molecular_function
def: "Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [CHEBI:28757, GOC:BHF, GOC:mah]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0070062
name: extracellular exosome
namespace: cellular_component
def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
synonym: "exosome" EXACT [GOC:pr]
synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles]
is_a: GO:1903561 ! extracellular vesicle
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070063
name: RNA polymerase binding
namespace: molecular_function
def: "Binding to an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0070064
name: proline-rich region binding
namespace: molecular_function
def: "Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070065
name: cellubrevin-VAMP4-syntaxin-16 complex
namespace: cellular_component
def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp3, Vamp4, Stx16)" NARROW [CORUM:875]
synonym: "Vamp3-Vamp4-Stx16 complex" NARROW [CORUM:875]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070066
name: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex
namespace: cellular_component
def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)" NARROW [CORUM:874]
synonym: "Vamp3-Vamp4-Vam8-Stx6 complex" NARROW [CORUM:874]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070067
name: syntaxin-6-syntaxin-16-Vti1a complex
namespace: cellular_component
def: "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070068
name: VAMP4-syntaxin-6-syntaxin-16-Vti1a complex
namespace: cellular_component
def: "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)" NARROW [CORUM:877]
synonym: "Vamp4-Stx6-Stx16-Vti1a complex" RELATED [CORUM:877]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070069
name: cytochrome complex
namespace: cellular_component
def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0070070
name: proton-transporting V-type ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah]
synonym: "V-ATPase assembly" RELATED []
synonym: "V-ATPase complex assembly" RELATED []
is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly

[Term]
id: GO:0070071
name: proton-transporting two-sector ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0070072
name: vacuolar proton-transporting V-type ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]
synonym: "V-ATPase assembly" BROAD []
synonym: "V-ATPase complex assembly" BROAD []
is_a: GO:0070070 ! proton-transporting V-type ATPase complex assembly

[Term]
id: GO:0070073
name: clustering of voltage-gated calcium channels
namespace: biological_process
def: "The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325]
synonym: "clustering of voltage gated calcium channels" EXACT []
synonym: "clustering of voltage-dependent calcium channels" EXACT []
synonym: "voltage-gated calcium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0070074
name: mononeme
namespace: cellular_component
def: "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts." [GOC:BHF, PMID:18048320]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0070075
name: tear secretion
namespace: biological_process
def: "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium." [GOC:rph]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0070076
name: obsolete histone lysine demethylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by the removal of a methyl group from a lysine residue." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0070077
name: obsolete histone arginine demethylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by the removal of a methyl group from an arginine residue." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0032452

[Term]
id: GO:0070078
name: obsolete histone H3-R2 demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone." [GOC:BHF, GOC:vk]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0070079
name: obsolete histone H4-R3 demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone." [GOC:BHF, GOC:vk]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0070080
name: titin Z domain binding
namespace: molecular_function
def: "Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34." [GOC:mah, InterPro:IPR015129]
synonym: "Z repeat domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070081
name: clathrin-sculpted monoamine transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines." [GOC:mg2]
synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle" EXACT []
synonym: "clathrin sculpted monoamine transport vesicle" EXACT [GOC:sl]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin-sculpted vesicle

[Term]
id: GO:0070082
name: clathrin-sculpted monoamine transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle." [GOC:mg2]
synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen" EXACT []
synonym: "clathrin sculpted monoamine transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle

[Term]
id: GO:0070083
name: clathrin-sculpted monoamine transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle." [GOC:mg2]
synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "clathrin sculpted monoamine transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle

[Term]
id: GO:0070084
name: obsolete protein initiator methionine removal
namespace: biological_process
def: "OBSOLETE. The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "removal of initiator methionine from protein" EXACT []
is_obsolete: true

[Term]
id: GO:0070085
name: glycosylation
namespace: biological_process
def: "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]
xref: Wikipedia:Glycosylation
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0070086
name: ubiquitin-dependent endocytosis
namespace: biological_process
def: "Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540]
synonym: "ubiquitin-mediated endocytosis" EXACT [GOC:jp]
is_a: GO:0006897 ! endocytosis
is_a: GO:0015031 ! protein transport
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0070087
name: chromo shadow domain binding
namespace: molecular_function
def: "Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain." [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093]
synonym: "chromoshadow domain binding" EXACT [GOC:vk]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070088
name: polyhydroxyalkanoate granule
namespace: cellular_component
def: "An inclusion body located in the cytoplasm of prokaryotes that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR." [GOC:mah, PMID:15762612]
synonym: "carbonosome" BROAD []
synonym: "PHA granule" EXACT []
synonym: "PHB granule" NARROW []
is_a: GO:0016234 ! inclusion body
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0070089
name: chloride-activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium cation by a channel that opens when a chloride ion has been bound by the channel complex or one of its constituent parts." [GOC:kmv, GOC:mtg_transport]
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022839 ! monoatomic ion-gated channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0070090
name: metaphase plate
namespace: cellular_component
def: "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah]
is_a: GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0070091
name: glucagon secretion
namespace: biological_process
def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070092
name: regulation of glucagon secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070093
name: negative regulation of glucagon secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "down regulation of glucagon secretion" EXACT []
synonym: "down-regulation of glucagon secretion" EXACT []
synonym: "downregulation of glucagon secretion" EXACT []
synonym: "inhibition of glucagon secretion" NARROW []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070094
name: positive regulation of glucagon secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "activation of glucagon secretion" NARROW []
synonym: "stimulation of glucagon secretion" NARROW []
synonym: "up regulation of glucagon secretion" EXACT []
synonym: "up-regulation of glucagon secretion" EXACT []
synonym: "upregulation of glucagon secretion" EXACT []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070095
name: fructose-6-phosphate binding
namespace: molecular_function
def: "Binding to fructose 6-phosphate." [GOC:mah]
synonym: "D-fructose 6-phosphate binding" NARROW []
synonym: "fructose 6-phosphate binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0070096
name: mitochondrial outer membrane translocase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex." [GOC:BHF, GOC:vk]
synonym: "mitochondrion outer membrane translocase complex assembly" EXACT []
synonym: "TOM complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0007008 ! outer mitochondrial membrane organization

[Term]
id: GO:0070097
name: delta-catenin binding
namespace: molecular_function
def: "Binding to the delta subunit of the catenin complex." [GOC:rph]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070098
name: chemokine-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:1990869 ! cellular response to chemokine

[Term]
id: GO:0070099
name: regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a chemokine-mediated signaling pathway." [GOC:mah]
synonym: "regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070100
name: negative regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a chemokine-mediated signaling pathway." [GOC:mah]
synonym: "negative regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
relationship: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070101
name: positive regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a chemokine-mediated signaling pathway." [GOC:mah]
synonym: "positive regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
relationship: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070102
name: interleukin-6-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]
synonym: "IL-6-mediated signaling pathway" RELATED []
synonym: "interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071354 ! cellular response to interleukin-6

[Term]
id: GO:0070103
name: regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of an interleukin-6-mediated signaling pathway." [GOC:BHF, GOC:mah]
synonym: "regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070104
name: negative regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway." [GOC:BHF, GOC:mah]
synonym: "negative regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway
relationship: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070105
name: positive regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway." [GOC:BHF, GOC:mah]
synonym: "positive regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway
relationship: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070106
name: interleukin-27-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]
synonym: "IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070107
name: regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of an interleukin-27-mediated signaling pathway." [GOC:BHF, GOC:mah]
synonym: "regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070108
name: negative regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of an interleukin-27-mediated signaling pathway." [GOC:BHF, GOC:mah]
synonym: "negative regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway
relationship: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070109
name: positive regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of an interleukin-27-mediated signaling pathway." [GOC:BHF, GOC:mah]
synonym: "positive regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway
relationship: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070110
name: ciliary neurotrophic factor receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR." [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0070111
name: organellar chromatophore
namespace: cellular_component
def: "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora." [GOC:expert_mm, PMID:18356055]
synonym: "Paulinella-type chromatophore" EXACT []
is_a: GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0070112
name: organellar chromatophore membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore membrane" EXACT [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070113
name: organellar chromatophore inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore inner membrane" EXACT [GOC:mah]
is_a: GO:0070112 ! organellar chromatophore membrane

[Term]
id: GO:0070114
name: organellar chromatophore outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore outer membrane" EXACT [GOC:mah]
is_a: GO:0043661 ! peribacteroid membrane
is_a: GO:0070112 ! organellar chromatophore membrane

[Term]
id: GO:0070115
name: organellar chromatophore intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers that surround an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore intermembrane space" EXACT [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070116
name: organellar chromatophore thylakoid
namespace: cellular_component
def: "A thylakoid located in an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore thylakoid" EXACT [GOC:mah]
is_a: GO:0009579 ! thylakoid
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070117
name: organellar chromatophore thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by an organellar chromatophore thylakoid membrane." [GOC:mah]
synonym: "Paulinella-type chromatophore thylakoid lumen" EXACT [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
relationship: part_of GO:0070116 ! organellar chromatophore thylakoid

[Term]
id: GO:0070118
name: organellar chromatophore thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore thylakoid membrane" EXACT [GOC:mah]
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0070112 ! organellar chromatophore membrane
relationship: part_of GO:0070116 ! organellar chromatophore thylakoid

[Term]
id: GO:0070119
name: ciliary neurotrophic factor binding
namespace: molecular_function
def: "Binding to the cytokine ciliary neurotrophic factor." [GOC:BHF, GOC:mah]
synonym: "CNTF binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070120
name: ciliary neurotrophic factor-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah]
synonym: "ciliary neurotrophic factor-mediated signalling pathway" EXACT [GOC:mah]
synonym: "CNTF-mediated signaling pathway" EXACT [GOC:rl]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070121
name: Kupffer's vesicle development
namespace: biological_process
def: "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period." [GOC:dgh]
synonym: "KV development" EXACT [GOC:dgh]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0070122
name: obsolete isopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond)." [GOC:mah, Wikipedia:Isopeptidase]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0008233

[Term]
id: GO:0070123
name: transforming growth factor beta receptor activity, type III
namespace: molecular_function
def: "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors." [GOC:BHF, GOC:mah, PMID:9759503]
synonym: "betaglycan" NARROW []
synonym: "endoglin" NARROW []
synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED []
synonym: "type III TGF-beta receptor activity" EXACT []
synonym: "type III TGFbeta receptor activity" EXACT []
synonym: "type III transforming growth factor beta receptor activity" EXACT []
is_a: GO:0005024 ! transforming growth factor beta receptor activity

[Term]
id: GO:0070124
name: mitochondrial translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah]
synonym: "mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0006413 ! translational initiation
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070125
name: mitochondrial translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]
synonym: "mitochondrial translation elongation" EXACT [GOC:mah]
is_a: GO:0006414 ! translational elongation
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070126
name: mitochondrial translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria]
synonym: "mitochondrial translation termination" EXACT [GOC:mah]
is_a: GO:0006415 ! translational termination
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070127
name: tRNA aminoacylation for mitochondrial protein translation
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006418 ! tRNA aminoacylation for protein translation
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070129
name: regulation of mitochondrial translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0062125 ! regulation of mitochondrial gene expression
relationship: regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070130
name: negative regulation of mitochondrial translation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
relationship: negatively_regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070131
name: positive regulation of mitochondrial translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
relationship: positively_regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070132
name: regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0070129 ! regulation of mitochondrial translation
relationship: regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070133
name: negative regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
relationship: negatively_regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070134
name: positive regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:0070131 ! positive regulation of mitochondrial translation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
relationship: positively_regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070135
name: beta-1,2-oligomannoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669]
synonym: "beta-1,2-oligomannoside metabolism" EXACT [GOC:mah]
is_a: GO:0010412 ! mannan metabolic process

[Term]
id: GO:0070136
name: beta-1,2-oligomannoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669]
synonym: "beta-1,2-oligomannoside anabolism" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside biosynthesis" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside formation" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside synthesis" EXACT [GOC:mah]
is_a: GO:0046354 ! mannan biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process
is_a: GO:0070135 ! beta-1,2-oligomannoside metabolic process

[Term]
id: GO:0070137
name: ubiquitin-like protein-specific endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)." [GOC:mah]
synonym: "small conjugating protein-specific endopeptidase activity" EXACT []
is_a: GO:0004197 ! cysteine-type endopeptidase activity
is_a: GO:0019783 ! ubiquitin-like protein peptidase activity

[Term]
id: GO:0070139
name: SUMO-specific endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah]
xref: Reactome:R-HSA-2990840 "SENP1,2,5 proteolytically process SUMO1"
xref: Reactome:R-HSA-2990842 "SENP1,2,5 proteolytically process SUMO2"
xref: Reactome:R-HSA-2993763 "SENP1,2,5 proteolytically process SUMO3"
is_a: GO:0070137 ! ubiquitin-like protein-specific endopeptidase activity

[Term]
id: GO:0070141
name: response to UV-A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:BHF, GOC:mah]
synonym: "response to UV-A light stimulus" EXACT []
synonym: "response to UV-A radiation stimulus" EXACT []
synonym: "response to UVA light stimulus" EXACT []
synonym: "response to UVA radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0070142
name: synaptic vesicle budding
namespace: biological_process
def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah]
is_a: GO:0006900 ! vesicle budding from membrane
relationship: part_of GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0070143
name: mitochondrial alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006419 ! alanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070144
name: mitochondrial arginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006420 ! arginyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070145
name: mitochondrial asparaginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006421 ! asparaginyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070146
name: mitochondrial aspartyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006422 ! aspartyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070147
name: mitochondrial cysteinyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006423 ! cysteinyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070148
name: mitochondrial glutaminyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006425 ! glutaminyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070149
name: mitochondrial glutamyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006424 ! glutamyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070150
name: mitochondrial glycyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006426 ! glycyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070151
name: mitochondrial histidyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006427 ! histidyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070152
name: mitochondrial isoleucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006428 ! isoleucyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070153
name: mitochondrial leucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006429 ! leucyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070154
name: mitochondrial lysyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006430 ! lysyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070155
name: mitochondrial methionyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006431 ! methionyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070156
name: mitochondrial phenylalanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006432 ! phenylalanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070157
name: mitochondrial prolyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006433 ! prolyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070158
name: mitochondrial seryl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006434 ! seryl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070159
name: mitochondrial threonyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006435 ! threonyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070160
name: tight junction
namespace: cellular_component
def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181]
synonym: "occluding cell junction" EXACT [GOC:mah]
synonym: "occluding junction" EXACT [GOC:mah]
xref: Wikipedia:Tight_junction
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0070161
name: anchoring junction
namespace: cellular_component
def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]
synonym: "anchoring cell junction" EXACT [GOC:mah]
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0070162
name: adiponectin secretion
namespace: biological_process
def: "The regulated release of adiponectin, a protein hormone, by adipose tissue." [GOC:BHF, GOC:rl]
is_a: GO:0009306 ! protein secretion
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0070163
name: regulation of adiponectin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:mah]
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070164
name: negative regulation of adiponectin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah]
synonym: "down regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "down-regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "downregulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "inhibition of adiponectin secretion" NARROW [GOC:mah]
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070163 ! regulation of adiponectin secretion
relationship: negatively_regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070165
name: positive regulation of adiponectin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah]
synonym: "activation of adiponectin secretion" NARROW [GOC:mah]
synonym: "stimulation of adiponectin secretion" NARROW [GOC:mah]
synonym: "up regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "up-regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "upregulation of adiponectin secretion" EXACT [GOC:mah]
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070163 ! regulation of adiponectin secretion
relationship: positively_regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070166
name: enamel mineralization
namespace: biological_process
def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." [GOC:BHF, GOC:mah, GOC:sl, PMID:10206335, PMID:16931858, PMID:21196346]
synonym: "enamel formation" RELATED [PMID:16931858]
is_a: GO:0034505 ! tooth mineralization
relationship: part_of GO:0097186 ! amelogenesis

[Term]
id: GO:0070167
name: regulation of biomineral tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0031214 ! biomineral tissue development

[Term]
id: GO:0070168
name: negative regulation of biomineral tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0070167 ! regulation of biomineral tissue development
relationship: negatively_regulates GO:0031214 ! biomineral tissue development

[Term]
id: GO:0070169
name: positive regulation of biomineral tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0070167 ! regulation of biomineral tissue development
relationship: positively_regulates GO:0031214 ! biomineral tissue development

[Term]
id: GO:0070170
name: regulation of tooth mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0070167 ! regulation of biomineral tissue development
relationship: regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070171
name: negative regulation of tooth mineralization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0070168 ! negative regulation of biomineral tissue development
is_a: GO:0070170 ! regulation of tooth mineralization
relationship: negatively_regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070172
name: positive regulation of tooth mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0070169 ! positive regulation of biomineral tissue development
is_a: GO:0070170 ! regulation of tooth mineralization
relationship: positively_regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070173
name: regulation of enamel mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0070170 ! regulation of tooth mineralization
relationship: regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070174
name: negative regulation of enamel mineralization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0070171 ! negative regulation of tooth mineralization
is_a: GO:0070173 ! regulation of enamel mineralization
relationship: negatively_regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070175
name: positive regulation of enamel mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0070172 ! positive regulation of tooth mineralization
is_a: GO:0070173 ! regulation of enamel mineralization
relationship: positively_regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070176
name: DRM complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059]
synonym: "DP/Rb/MuvB" EXACT [PMID:17075059]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070177
name: contractile vacuole discharge
namespace: biological_process
def: "The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane." [GOC:mah, PMID:10369671]
is_a: GO:0045055 ! regulated exocytosis

[Term]
id: GO:0070178
name: D-serine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:jsg, GOC:mah]
synonym: "D-serine metabolism" EXACT []
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0070179
name: D-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah]
synonym: "D-serine anabolism" EXACT []
synonym: "D-serine biosynthesis" EXACT []
synonym: "D-serine formation" EXACT []
synonym: "D-serine synthesis" EXACT []
is_a: GO:0046437 ! D-amino acid biosynthetic process
is_a: GO:0070178 ! D-serine metabolic process

[Term]
id: GO:0070180
name: large ribosomal subunit rRNA binding
namespace: molecular_function
def: "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]
synonym: "25S rRNA binding" EXACT [GOC:elh]
synonym: "LSU rRNA binding" EXACT []
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0070181
name: small ribosomal subunit rRNA binding
namespace: molecular_function
def: "Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh]
synonym: "18S rRNA binding" EXACT [GOC:elh]
synonym: "SSU rRNA binding" EXACT []
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0070182
name: DNA polymerase binding
namespace: molecular_function
def: "Binding to a DNA polymerase." [GOC:BHF, GOC:mah]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0070183
name: mitochondrial tryptophanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006436 ! tryptophanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070184
name: mitochondrial tyrosyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006437 ! tyrosyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070185
name: mitochondrial valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006438 ! valyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070186
name: growth hormone activity
namespace: molecular_function
def: "The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth." [GOC:BHF, GOC:mah, PMID:11445442]
synonym: "GH activity" EXACT [PMID:11445442]
synonym: "pituitary growth hormone activity" NARROW [GOC:vk]
synonym: "placental growth hormone activity" NARROW [GOC:vk]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0070187
name: shelterin complex
namespace: cellular_component
def: "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1." [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880]
synonym: "Pot1 complex" EXACT [GOC:vw]
synonym: "Pot1-Tpz1 complex" EXACT [GOC:vw]
synonym: "telosome" EXACT [GOC:mah, GOC:vw]
is_a: GO:0000783 ! nuclear telomere cap complex

[Term]
id: GO:0070188
name: obsolete Stn1-Ten1 complex
namespace: cellular_component
def: "OBSOLETE. A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present." [GOC:mah, GOC:vw, PMID:17715303, PMID:19064932]
comment: This term was made obsolete because it was inaccurate.
is_obsolete: true
replaced_by: GO:1990879

[Term]
id: GO:0070189
name: kynurenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]
synonym: "kynurenine metabolism" EXACT []
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0070190
name: obsolete inositol hexakisphosphate 1-kinase or 3-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "inositol hexakisphosphate 1-kinase or 3-kinase activity" EXACT []
is_obsolete: true
consider: GO:0052723
consider: GO:0052724

[Term]
id: GO:0070191
name: obsolete methionine-R-sulfoxide reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mcc, PMID:17535911, PMID:19049972]
comment: The reason for obsoletion is that this term is equivalent to GO:0033745 L-methionine-(R)-S-oxide reductase activity.
is_obsolete: true
replaced_by: GO:0033745

[Term]
id: GO:0070192
name: chromosome organization involved in meiotic cell cycle
namespace: biological_process
def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah]
synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah]
synonym: "meiotic chromosome organization" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0070193
name: synaptonemal complex organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah]
synonym: "synaptonemal complex organisation" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0070194
name: synaptonemal complex disassembly
namespace: biological_process
def: "The controlled breakdown of a synaptonemal complex." [GOC:mah]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0070193 ! synaptonemal complex organization

[Term]
id: GO:0070195
name: growth hormone receptor complex
namespace: cellular_component
def: "A receptor complex that consists of two identical subunits and binds growth hormone." [GOC:BHF, GOC:mah, GOC:vk, PMID:11445442]
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0070196
name: eukaryotic translation initiation factor 3 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex." [GOC:mah]
synonym: "eIF-3 assembly" EXACT [GOC:mah]
synonym: "eIF3 assembly" EXACT [GOC:mah]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0070197
name: meiotic attachment of telomere to nuclear envelope
namespace: biological_process
def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation." [GOC:jp, GOC:pr, GOC:vw, PMID:18818742]
synonym: "attachment of telomeres to nuclear envelope" BROAD []
synonym: "attachment of telomeric chromatin to nuclear envelope" BROAD []
is_a: GO:0097240 ! chromosome attachment to the nuclear envelope
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0044821 ! meiotic telomere tethering at nuclear periphery

[Term]
id: GO:0070198
name: protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "protein localisation to chromosome, telomeric region" EXACT [GOC:mah]
synonym: "protein localization to telomere" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0070199
name: establishment of protein localization to chromosome
namespace: biological_process
def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0070200
name: establishment of protein localization to telomere
namespace: biological_process
def: "The directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to telomere" EXACT [GOC:mah]
synonym: "establishment of protein localization to chromosome, telomeric region" EXACT [GOC:mah]
is_a: GO:0070198 ! protein localization to chromosome, telomeric region
is_a: GO:0070199 ! establishment of protein localization to chromosome

[Term]
id: GO:0070201
name: regulation of establishment of protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0045184 ! establishment of protein localization

[Term]
id: GO:0070202
name: regulation of establishment of protein localization to chromosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0070201 ! regulation of establishment of protein localization
relationship: regulates GO:0070199 ! establishment of protein localization to chromosome

[Term]
id: GO:0070203
name: regulation of establishment of protein localization to telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation to telomere" EXACT [GOC:mah]
is_a: GO:0070202 ! regulation of establishment of protein localization to chromosome
is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region
relationship: regulates GO:0070200 ! establishment of protein localization to telomere

[Term]
id: GO:0070204
name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + H+ + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2." [RHEA:25593]
synonym: "MenD" RELATED [EC:2.2.1.9]
synonym: "SEPHCHC synthase activity" RELATED [EC:2.2.1.9]
xref: EC:2.2.1.9
xref: KEGG_REACTION:R08165
xref: MetaCyc:2.5.1.64-RXN
xref: RHEA:25593
is_a: GO:0016744 ! transketolase or transaldolase activity

[Term]
id: GO:0070205
name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate." [EC:4.2.99.20, RHEA:25597]
synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" RELATED [EC:4.2.99.20]
synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" RELATED [EC:4.2.99.20]
synonym: "MenH" RELATED [EC:4.2.99.20]
synonym: "SHCHC synthase activity" RELATED [EC:4.2.99.20]
synonym: "YfbB" RELATED [EC:4.2.99.20]
xref: EC:4.2.99.20
xref: KEGG_REACTION:R08166
xref: MetaCyc:RXN-9310
xref: RHEA:25597
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0070206
name: protein trimerization
namespace: biological_process
def: "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits." [GOC:hjd]
synonym: "protein trimer assembly" EXACT [GOC:hjd]
synonym: "protein trimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein trimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein trimer formation" EXACT [GOC:hjd]
is_a: GO:0051259 ! protein complex oligomerization

[Term]
id: GO:0070207
name: protein homotrimerization
namespace: biological_process
def: "The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits." [GOC:hjd]
synonym: "protein homotrimer assembly" EXACT [GOC:hjd]
synonym: "protein homotrimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein homotrimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein homotrimer formation" EXACT [GOC:hjd]
is_a: GO:0051260 ! protein homooligomerization
is_a: GO:0070206 ! protein trimerization

[Term]
id: GO:0070208
name: protein heterotrimerization
namespace: biological_process
def: "The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical." [GOC:hjd]
synonym: "protein heterotrimer assembly" EXACT [GOC:hjd]
synonym: "protein heterotrimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein heterotrimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein heterotrimer formation" EXACT [GOC:hjd]
is_a: GO:0051291 ! protein heterooligomerization
is_a: GO:0070206 ! protein trimerization

[Term]
id: GO:0070209
name: obsolete ASTRA complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720, PMID:22505622]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using TTT complex.
is_obsolete: true
replaced_by: GO:0110078

[Term]
id: GO:0070210
name: Rpd3L-Expanded complex
namespace: cellular_component
def: "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]
synonym: "Clr6-LE complex" EXACT [GOC:vw]
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0070211
name: Snt2C complex
namespace: cellular_component
def: "A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p." [GOC:rb, PMID:19040720]
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0070212
name: protein poly-ADP-ribosylation
namespace: biological_process
def: "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]
synonym: "addition of poly-ADP-ribose to protein" EXACT [GOC:rl]
synonym: "poly(ADP-ribose) addition to protein" EXACT [GOC:rl]
synonym: "protein amino acid poly-ADP-ribosylation" EXACT [GOC:bf]
synonym: "protein poly(ADP-ribose) metabolism" RELATED [GOC:rl]
synonym: "protein poly(ADP-ribose) synthesis" EXACT [GOC:rl]
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0070213
name: protein auto-ADP-ribosylation
namespace: biological_process
def: "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GOC:BHF, GOC:rl]
synonym: "protein amino acid auto-ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0070214
name: CSK-GAP-A.p62 complex
namespace: cellular_component
def: "A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation." [PMID:7544435]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0070215
name: obsolete MDM2 binding
namespace: molecular_function
def: "OBSOLETE. Binding to an isoform of the MDM2 protein, a negative regulator of p53." [GOC:mah, GOC:nln]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "MDM2 binding" EXACT []
is_obsolete: true
replaced_by: GO:0097371

[Term]
id: GO:0070216
name: obsolete MDM4 binding
namespace: molecular_function
def: "OBSOLETE. Binding to an isoform of the MDM4 protein, a negative regulator of p53." [GOC:mah, GOC:nln]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "MDM4 binding" EXACT []
synonym: "MDMX binding" EXACT [GOC:nln]
is_obsolete: true
replaced_by: GO:0097371

[Term]
id: GO:0070217
name: transcription factor TFIIIB complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex." [GOC:mah]
synonym: "TFIIIB assembly" EXACT [GOC:mah]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0070218
name: obsolete sulfide ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell." [GOC:mah]
comment: This term was obsoleted because it does not represent a GO process.
synonym: "sulfide generation" RELATED [GOC:mah]
synonym: "sulfide homeostasis" EXACT [GOC:mah]
synonym: "sulfide production" RELATED [GOC:mah]
synonym: "sulphide generation" RELATED [GOC:mah]
synonym: "sulphide homeostasis" EXACT [GOC:mah]
synonym: "sulphide ion homeostasis" EXACT [GOC:mah]
synonym: "sulphide production" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0140974

[Term]
id: GO:0070219
name: obsolete intracellular sulfide ion homeostasis
namespace: biological_process
def: "OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of sulfide ions within a cell." [GOC:mah]
comment: This term was obsoleted because it does not represent a GO process.
synonym: "cellular sulfide homeostasis" EXACT [GOC:mah]
synonym: "cellular sulfide ion homeostasis" EXACT []
synonym: "cellular sulphide homeostasis" EXACT [GOC:mah]
synonym: "cellular sulphide ion homeostasis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0140974

[Term]
id: GO:0070220
name: aerobic sulfur oxidation
namespace: biological_process
def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen." [MetaCyc:SULFUROX-PWY]
synonym: "aerobic sulphur oxidation" EXACT [GOC:mah]
xref: MetaCyc:SULFUROX-PWY
is_a: GO:0019417 ! sulfur oxidation

[Term]
id: GO:0070221
name: sulfide oxidation, using sulfide:quinone oxidoreductase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase." [MetaCyc:P222-PWY]
synonym: "sulfide oxidation, using sulfide-quinone reductase" EXACT [GOC:mah, MetaCyc:P222-PWY]
synonym: "sulphide oxidation, using sulfide:quinone oxidoreductase" EXACT [GOC:mah]
xref: MetaCyc:P222-PWY
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070222
name: sulfide oxidation, using sulfide dehydrogenase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase." [MetaCyc:PWY-5274]
synonym: "sulphide oxidation, using sulfide dehydrogenase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5274
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070223
name: sulfide oxidation, using sulfur dioxygenase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase." [MetaCyc:PWY-5285]
synonym: "sulphide oxidation, using sulfur dioxygenase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5285
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070224
name: sulfide:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone." [RHEA:30239]
comment: Note that EC:1.8.5.4 describes this reaction as bacterial-specific, but it has also been observed in eukaryotes (PMID:22852582, PMID:10224084).
synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314]
synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah]
xref: MetaCyc:R17-RXN
xref: Reactome:R-HSA-1614665 "SQR oxidizes sulfide to bound persulfide"
xref: RHEA:30239
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0070225
name: sulfide dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c." [RHEA:30223]
synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8156]
synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah]
xref: EC:1.8.2.3
xref: MetaCyc:RXN-8156
xref: RHEA:30223
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0070226
name: sulfur:ferric ion oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+." [MetaCyc:SULFFEOXIDO-RXN]
synonym: "hydrogen sulfide:ferric ion oxidoreductase" EXACT [MetaCyc:SULFFEOXIDO-RXN]
xref: MetaCyc:SULFFEOXIDO-RXN
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0070227
name: lymphocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "lymphocyte apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process

[Term]
id: GO:0070228
name: regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "regulation of lymphocyte apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
relationship: regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070229
name: negative regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "negative regulation of lymphocyte apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
relationship: negatively_regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070230
name: positive regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "positive regulation of lymphocyte apoptosis" NARROW []
synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
relationship: positively_regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070231
name: T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "T cell apoptosis" NARROW []
synonym: "T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "T-cell apoptosis" EXACT [GOC:add]
synonym: "T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070232
name: regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "regulation of T cell apoptosis" NARROW []
synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
relationship: regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070233
name: negative regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of T cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of T cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T cell apoptosis" NARROW []
synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
relationship: negatively_regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070234
name: positive regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of T cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T cell apoptosis" NARROW []
synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
synonym: "stimulation of T cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of T cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
relationship: positively_regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070235
name: regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that modulates the occurrence or rate of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "regulation of AICD" BROAD [GOC:add]
synonym: "regulation of antigen-driven apoptosis" BROAD [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0070232 ! regulation of T cell apoptotic process
relationship: regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070236
name: negative regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "down regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "down-regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "downregulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "inhibition of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "negative regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "negative regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "negative regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "negative regulation of AICD" BROAD [GOC:add]
synonym: "negative regulation of antigen-driven apoptosis" BROAD []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:0070235 ! regulation of activation-induced cell death of T cells
relationship: negatively_regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070237
name: positive regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "activation of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "positive regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "positive regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "positive regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "positive regulation of AICD" BROAD [GOC:add]
synonym: "positive regulation of antigen-driven apoptosis" BROAD [GOC:add]
synonym: "stimulation of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "up regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "up-regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "upregulation of activation-induced cell death of T cells" EXACT [GOC:add]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:0070235 ! regulation of activation-induced cell death of T cells
relationship: positively_regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070238
name: activated T cell autonomous cell death
namespace: biological_process
def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "ACAD" BROAD [GOC:add]
synonym: "activated cell autonomous cell death" BROAD [GOC:add]
synonym: "activated T cell apoptosis" BROAD [GOC:add]
synonym: "activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0070231 ! T cell apoptotic process
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0070239
name: regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that modulates the occurrence or rate of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of ACAD" BROAD [GOC:add]
synonym: "regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0070232 ! regulation of T cell apoptotic process
relationship: regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070240
name: negative regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "down-regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "downregulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "inhibition of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "negative regulation of ACAD" BROAD [GOC:add]
synonym: "negative regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "negative regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "negative regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "negative regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:0070239 ! regulation of activated T cell autonomous cell death
relationship: negatively_regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070241
name: positive regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "positive regulation of ACAD" BROAD [GOC:add]
synonym: "positive regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "positive regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "positive regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "positive regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "stimulation of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "up regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "up-regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "upregulation of activated T cell autonomous cell death" EXACT [GOC:add]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:0070239 ! regulation of activated T cell autonomous cell death
relationship: positively_regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070242
name: thymocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a thymocyte, an immature T cell located in the thymus." [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "immature T cell apoptosis" RELATED [GOC:add]
synonym: "thymocyte apoptosis" NARROW []
is_a: GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070243
name: regulation of thymocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "regulation of immature T cell apoptosis" RELATED [GOC:add]
synonym: "regulation of thymocyte apoptosis" NARROW []
is_a: GO:0070232 ! regulation of T cell apoptotic process
relationship: regulates GO:0070242 ! thymocyte apoptotic process

[Term]
id: GO:0070244
name: negative regulation of thymocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "down regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of thymocyte apoptosis" NARROW [GOC:add]
synonym: "negative regulation of immature T cell apoptosis" RELATED [GOC:add]
synonym: "negative regulation of thymocyte apoptosis" NARROW []
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:0070243 ! regulation of thymocyte apoptotic process
relationship: negatively_regulates GO:0070242 ! thymocyte apoptotic process

[Term]
id: GO:0070245
name: positive regulation of thymocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "activation of thymocyte apoptosis" NARROW [GOC:add]
synonym: "positive regulation of immature T cell apoptosis" RELATED [GOC:add]
synonym: "positive regulation of thymocyte apoptosis" NARROW []
synonym: "stimulation of thymocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of thymocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:0070243 ! regulation of thymocyte apoptotic process
relationship: positively_regulates GO:0070242 ! thymocyte apoptotic process

[Term]
id: GO:0070246
name: natural killer cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation." [CL:0000623, GOC:add, GOC:mtg_apoptosis, PMID:15728472]
synonym: "natural killer cell apoptosis" NARROW []
synonym: "NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070247
name: regulation of natural killer cell apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of natural killer cell apoptosis" NARROW []
synonym: "regulation of NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
relationship: regulates GO:0070246 ! natural killer cell apoptotic process

[Term]
id: GO:0070248
name: negative regulation of natural killer cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of natural killer cell apoptosis" NARROW []
synonym: "negative regulation of NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
is_a: GO:0070247 ! regulation of natural killer cell apoptotic process
relationship: negatively_regulates GO:0070246 ! natural killer cell apoptotic process

[Term]
id: GO:0070249
name: positive regulation of natural killer cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of natural killer cell apoptosis" NARROW []
synonym: "positive regulation of NK cell apoptosis" EXACT [GOC:add]
synonym: "stimulation of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of natural killer cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
is_a: GO:0070247 ! regulation of natural killer cell apoptotic process
relationship: positively_regulates GO:0070246 ! natural killer cell apoptotic process

[Term]
id: GO:0070250
name: mating projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone." [GOC:jp]
synonym: "shmoo membrane" NARROW [GOC:jp]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0070251
name: pristanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA." [GOC:pde, PMID:10198260]
synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOC:mah]
synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-389632 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate"
xref: RHEA:47264
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0070252
name: actin-mediated cell contraction
namespace: biological_process
def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah]
is_a: GO:0030048 ! actin filament-based movement

[Term]
id: GO:0070253
name: somatostatin secretion
namespace: biological_process
def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070254
name: mucus secretion
namespace: biological_process
def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544]
synonym: "mucus production" EXACT [GOC:add]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0070255
name: regulation of mucus secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "regulation of mucus production" EXACT [GOC:add]
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070256
name: negative regulation of mucus secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "negative regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
relationship: negatively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070257
name: positive regulation of mucus secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "positive regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
relationship: positively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070258
name: inner membrane pellicle complex
namespace: cellular_component
def: "A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell." [GOC:mah, PMID:12456714]
synonym: "inner membrane complex" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0070259
name: tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA." [GOC:elh, PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0070260
name: 5'-tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity

[Term]
id: GO:0070262
name: peptidyl-serine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine." [GOC:bf]
subset: gocheck_obsoletion_candidate
is_a: GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0070263
name: external side of fungal-type cell wall
namespace: cellular_component
def: "The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents." [GOC:mah]
is_a: GO:0010339 ! external side of cell wall
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0070264
name: transcription factor TFIIIE complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins." [GOC:jp, PMID:19116144]
is_a: GO:0090576 ! RNA polymerase III transcription regulator complex

[Term]
id: GO:0070265
name: obsolete necrotic cell death
namespace: biological_process
def: "OBSOLETE. A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]
comment: The reason for obsoletion is that this term represent an assay and not a GO process.\n The reason for obsoletion is that this represents a phenotype.
synonym: "cellular necrosis" EXACT [GOC:add]
synonym: "necrosis" BROAD [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070266
name: necroptotic process
namespace: biological_process
alt_id: GO:0060553
alt_id: GO:0060554
alt_id: GO:0060555
def: "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153]
comment: Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
synonym: "activation of necroptosis" RELATED []
synonym: "activation of necroptosis by extracellular signals" RELATED []
synonym: "activation of necroptosis in response to extracellular signals" RELATED []
synonym: "activation of necroptosis of activated-T cells" RELATED []
synonym: "establishment of necroptosis" RELATED []
synonym: "establishment of necroptosis of activated-T cells" RELATED []
synonym: "extracellular signal-induced necroptosis" RELATED []
synonym: "induction of necroptosis" BROAD []
synonym: "induction of necroptosis by extracellular signals" BROAD []
synonym: "induction of necroptosis of activated-T cells" BROAD []
synonym: "necroptosis" NARROW []
synonym: "PARP-dependent cell death" RELATED []
synonym: "parthanatos" RELATED []
synonym: "programmed necrosis" BROAD []
synonym: "programmed necrotic cell death" BROAD [GOC:mah]
synonym: "RIPK1-mediated regulated necrosis" EXACT []
synonym: "TNF-induced necroptosis" NARROW [PMID:21876153]
is_a: GO:0097300 ! programmed necrotic cell death

[Term]
id: GO:0070267
name: obsolete oncosis
namespace: biological_process
def: "OBSOLETE. A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death." [PMID:17873035, PMID:18846107]
comment: The reason for obsoletion is that this term represent an assay and not a GO process.\n The reason for obsoletion is that this represents a phenotype.
is_obsolete: true

[Term]
id: GO:0070268
name: cornification
namespace: biological_process
def: "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability)." [GOC:krc, PMID:18846107]
is_a: GO:0012501 ! programmed cell death
relationship: part_of GO:0031424 ! keratinization

[Term]
id: GO:0070269
name: pyroptotic inflammatory response
namespace: biological_process
def: "A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death." [PMID:18846107, PMID:21760595, PMID:33883744]
synonym: "pyroptosis" BROAD []
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0070270
name: obsolete mitotic catastrophe
namespace: biological_process
def: "OBSOLETE. A type of programmed cell death that occurs during or shortly after a dysregulated or failed mitosis and can be accompanied by morphological alterations including micronucleation and multinucleation." [PMID:18846107]
comment: This term was made obsolete because it does not refer to a true process, but rather to the consequences of aberrations occurred during mitosis.
synonym: "cell death occurring during metaphase" RELATED [PMID:18846107]
synonym: "cell death preceded by multinucleation" RELATED [PMID:18846107]
synonym: "mitotic catastrophe" EXACT []
is_obsolete: true

[Term]
id: GO:0070271
name: obsolete protein complex biogenesis
namespace: biological_process
def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex." [GOC:mah]
synonym: "protein complex biogenesis and assembly" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070272
name: obsolete proton-transporting ATP synthase complex biogenesis
namespace: biological_process
def: "OBSOLETE. The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mah, PMID:19103153]
comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation.
synonym: "F-type ATPase complex biogenesis" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070273
name: phosphatidylinositol-4-phosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0070274
name: RES complex
namespace: cellular_component
def: "A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p." [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360]
synonym: "pre-mRNA retention and splicing complex" EXACT [GOC:sre]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070275
name: aerobic ammonia oxidation to nitrite via pyruvic oxime
namespace: biological_process
def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite." [MetaCyc:PWY-2242]
xref: MetaCyc:PWY-2242
is_a: GO:0019329 ! ammonia oxidation

[Term]
id: GO:0070276
name: halogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [GOC:mah]
synonym: "halogen metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0070277
name: obsolete iodide oxidation
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0004447

[Term]
id: GO:0070278
name: extracellular matrix constituent secretion
namespace: biological_process
def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah]
synonym: "ECM constituent secretion" EXACT [GOC:mah]
synonym: "ECM secretion" EXACT [GOC:mah]
is_a: GO:0032940 ! secretion by cell
relationship: part_of GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0070279
name: vitamin B6 binding
namespace: molecular_function
def: "Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate." [GOC:mah]
is_a: GO:0019842 ! vitamin binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0070280
name: pyridoxal binding
namespace: molecular_function
def: "Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah]
is_a: GO:0043169 ! cation binding
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070281
name: pyridoxamine binding
namespace: molecular_function
def: "Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16410, GOC:mah]
is_a: GO:0043169 ! cation binding
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070282
name: pyridoxine binding
namespace: molecular_function
def: "Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16709, GOC:mah]
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070284
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine." [PMID:18953358]
synonym: "HMP-P synthase activity" EXACT [PMID:18953358]
synonym: "ThiC" RELATED [PMID:18953358]
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0070285
name: pigment cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0070286
name: axonemal dynein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]
synonym: "dynein arm assembly" EXACT [GOC:vk, PMID:19944405]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0035082 ! axoneme assembly

[Term]
id: GO:0070287
name: ferritin receptor activity
namespace: molecular_function
def: "Combining with ferritin, and delivering ferritin into the cell via endocytosis." [GOC:bf, PMID:17459943, PMID:19154717]
synonym: "ferritin complex receptor activity" EXACT [GOC:mah]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0070288
name: ferritin complex
namespace: cellular_component
def: "A protein complex that binds iron and acts as a major iron storage system. There are three major subclasses of ferritins: the classical ferritins (Ftn), the heme-containing bacterioferritins (Bfr) and the DNA-binding proteins from starved cells (Dps). Ftn and Bfr are made of 24 subunits, whereas Dps are smaller with 12 subunits. Ftn is found in most kindoms, while Bfr and Dps are restricted to prokaryotes." [PMID:19154717, PMID:33881539]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0070289
name: obsolete extracellular ferritin complex
namespace: cellular_component
def: "OBSOLETE. A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains." [GOC:mah, PMID:19154717]
comment: The reason for obsoletion is that this term represents a cellular component and its location.
synonym: "serum ferritin complex" RELATED [PMID:19154717]
is_obsolete: true
replaced_by: GO:0070288

[Term]
id: GO:0070290
name: N-acylphosphatidylethanolamine-specific phospholipase D activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine (NAE) + H+." [PMID:14634025, PMID:15878693, RHEA:33159]
subset: goslim_chembl
synonym: "N-acyl-phosphatidylethanolamine-specific phospholipase D activity" EXACT []
synonym: "NAPE-specific phospholipase D activity" EXACT []
xref: EC:3.1.4.54
xref: MetaCyc:RXN-12116
xref: Reactome:R-HSA-2466831 "A2PE hydrolyses to A2E"
xref: RHEA:33159
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0070291
name: N-acylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group." [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693]
synonym: "N-acylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693]
synonym: "NAE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15878693]
synonym: "NAE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process

[Term]
id: GO:0070292
name: N-acylphosphatidylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]
synonym: "N-acylphosphatidylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693]
synonym: "NAPE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15878693]
synonym: "NAPE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693]
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0070293
name: renal absorption
namespace: biological_process
def: "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:dph, GOC:mah, GOC:yaf]
synonym: "nephron absorption" EXACT [GOC:mah]
synonym: "renal reabsorption" EXACT [GOC:dph]
is_a: GO:0003014 ! renal system process

[Term]
id: GO:0070294
name: renal sodium ion absorption
namespace: biological_process
def: "A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah]
synonym: "nephron sodium ion absorption" EXACT [GOC:mah]
synonym: "renal sodium ion reabsorption" EXACT [GOC:dph]
is_a: GO:0003096 ! renal sodium ion transport
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0070295
name: renal water absorption
namespace: biological_process
def: "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah]
synonym: "nephron water absorption" EXACT [GOC:mah]
synonym: "renal water reabsorption" EXACT [GOC:dph]
is_a: GO:0003097 ! renal water transport
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0070296
name: sarcoplasmic reticulum calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum." [GOC:BHF, GOC:vk]
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0070297
name: regulation of phosphorelay signal transduction system
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah]
synonym: "regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "regulation of two-component signal transduction system" EXACT [GOC:bf, GOC:mah]
synonym: "regulation of two-component signal transduction system (phosphorelay)" NARROW []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0000160 ! phosphorelay signal transduction system

[Term]
id: GO:0070298
name: negative regulation of phosphorelay signal transduction system
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah]
synonym: "down regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "down-regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "downregulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "inhibition of two-component signal transduction" NARROW [GOC:mah]
synonym: "negative regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "negative regulation of two-component signal transduction system (phosphorelay)" NARROW []
is_a: GO:0070297 ! regulation of phosphorelay signal transduction system
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0000160 ! phosphorelay signal transduction system

[Term]
id: GO:0070299
name: positive regulation of phosphorelay signal transduction system
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah]
synonym: "activation of two-component signal transduction" NARROW [GOC:mah]
synonym: "positive regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "positive regulation of two-component signal transduction system (phosphorelay)" NARROW []
synonym: "stimulation of two-component signal transduction" NARROW [GOC:mah]
synonym: "up regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "up-regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "upregulation of two-component signal transduction" EXACT [GOC:mah]
is_a: GO:0070297 ! regulation of phosphorelay signal transduction system
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0000160 ! phosphorelay signal transduction system

[Term]
id: GO:0070300
name: phosphatidic acid binding
namespace: molecular_function
def: "Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [CHEBI:16337, GOC:jp, ISBN:0198506732]
synonym: "phosphatidate binding" EXACT [GOC:jp]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0070301
name: cellular response to hydrogen peroxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah]
is_a: GO:0034614 ! cellular response to reactive oxygen species
is_a: GO:0042542 ! response to hydrogen peroxide

[Term]
id: GO:0070302
name: regulation of stress-activated protein kinase signaling cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade." [GOC:mah]
synonym: "regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "regulation of stress-activated protein kinase signaling pathway" EXACT []
synonym: "regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0070303
name: negative regulation of stress-activated protein kinase signaling cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah]
synonym: "down regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "down-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "downregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "inhibition of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "negative regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of stress-activated protein kinase signaling pathway" EXACT []
synonym: "negative regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0070304
name: positive regulation of stress-activated protein kinase signaling cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah]
synonym: "activation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "positive regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of stress-activated protein kinase signaling pathway" EXACT []
synonym: "positive regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
synonym: "stimulation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "up regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "up-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "upregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0070305
name: response to cGMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:sl]
synonym: "response to 3',5' cGMP" EXACT [GOC:mah]
synonym: "response to 3',5'-cGMP" EXACT [GOC:mah]
synonym: "response to cyclic GMP" EXACT [GOC:mah]
synonym: "response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0070306
name: lens fiber cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell differentiation" EXACT [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0002088 ! lens development in camera-type eye

[Term]
id: GO:0070307
name: lens fiber cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell development" EXACT [GOC:mah]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:0070308
name: lens fiber cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell fate commitment" EXACT [GOC:mah]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:0070309
name: lens fiber cell morphogenesis
namespace: biological_process
def: "The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "elongation of lens fiber cell" NARROW [GOC:mah, GOC:vk]
synonym: "lens fiber cell morphogenesis during differentiation" EXACT systematic_synonym [GOC:mah]
synonym: "lens fibre cell morphogenesis" EXACT [GOC:mah]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye
relationship: part_of GO:0070307 ! lens fiber cell development

[Term]
id: GO:0070310
name: ATR-ATRIP complex
namespace: cellular_component
def: "A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A." [GOC:mah, PMID:14724280]
synonym: "Mec1-Lcd1 complex" NARROW [PMID:17339343]
synonym: "Rad3-Rad26 complex" NARROW [PMID:17339343]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070311
name: nucleosomal methylation activator complex
namespace: cellular_component
def: "A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription." [GOC:mah, PMID:14729568]
synonym: "NUMAC" EXACT [PMID:14729568]
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0070312
name: RAD52-ERCC4-ERCC1 complex
namespace: cellular_component
def: "A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein." [PMID:14734547]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070313
name: RGS6-DNMT1-DMAP1 complex
namespace: cellular_component
def: "A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1." [GOC:mah, PMID:14734556]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070314
name: G1 to G0 transition
namespace: biological_process
def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence." [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194]
synonym: "cell cycle quiescence" RELATED [GOC:mah]
synonym: "establishment of cell quiescence" EXACT [GOC:mah]
synonym: "G1/G0 transition" EXACT [GOC:mah]
synonym: "stationary phase" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0070315
name: G1 to G0 transition involved in cell differentiation
namespace: biological_process
def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation." [GOC:mah, ISBN:0815316194]
synonym: "G1/G0 transition involved in cell differentiation" EXACT [GOC:mah]
is_a: GO:0070314 ! G1 to G0 transition
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0070316
name: regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070317
name: negative regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
synonym: "maintenance of cell cycle quiescence" EXACT [GOC:mah]
synonym: "maintenance of cell quiescence" EXACT [GOC:mah]
synonym: "maintenance of G0 arrest" EXACT [GOC:mah]
synonym: "maintenance of G0 phase" EXACT [GOC:mah]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0070316 ! regulation of G0 to G1 transition
relationship: negatively_regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070318
name: positive regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
is_a: GO:0070316 ! regulation of G0 to G1 transition
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070319
name: Golgi to plasma membrane transport vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "Golgi to plasma membrane constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi-plasma membrane transport vesicle" EXACT [GOC:mah]
is_a: GO:0070382 ! exocytic vesicle

[Term]
id: GO:0070320
name: inward rectifier potassium channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel." [GOC:mah]
is_a: GO:0019870 ! potassium channel inhibitor activity

[Term]
id: GO:0070321
name: obsolete regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
comment: This term was obsoleted because it was redundant with GO:1903832 ; regulation of cellular response to amino acid starvation.
is_obsolete: true
consider: GO:1903832

[Term]
id: GO:0070322
name: obsolete negative regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
comment: This term was obsoleted because it was redundant with GO:1903574 ; negative regulation of cellular response to amino acid starvation.
synonym: "down regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "down-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "downregulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "inhibition of translation in response to nitrogen starvation" NARROW [GOC:mah]
is_obsolete: true
consider: GO:1903574

[Term]
id: GO:0070323
name: obsolete positive regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
comment: This term was obsoleted because it was redundant with GO:1903833 ; positive regulation of cellular response to amino acid starvation.
synonym: "activation of translation in response to nitrogen starvation" NARROW [GOC:mah]
synonym: "stimulation of translation in response to nitrogen starvation" NARROW [GOC:mah]
synonym: "up regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "up-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "upregulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:1903833

[Term]
id: GO:0070324
name: thyroid hormone binding
namespace: molecular_function
def: "Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph]
subset: goslim_chembl
synonym: "thyroxine binding" NARROW [GOC:mah]
synonym: "triiodothyronine binding" NARROW [GOC:mah]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0070325
name: lipoprotein particle receptor binding
namespace: molecular_function
def: "Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0070326
name: very-low-density lipoprotein particle receptor binding
namespace: molecular_function
def: "Binding to a very-low-density lipoprotein receptor." [GOC:BHF, GOC:mah]
synonym: "apolipoprotein E receptor binding" RELATED [GOC:rl]
synonym: "very-low-density lipoprotein receptor binding" EXACT [GOC:bf, GOC:dph]
synonym: "VLDL receptor binding" EXACT [GOC:mah]
synonym: "VLDLR binding" EXACT [GOC:mah]
is_a: GO:0070325 ! lipoprotein particle receptor binding

[Term]
id: GO:0070327
name: thyroid hormone transport
namespace: biological_process
def: "The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:rph]
synonym: "thyroxine transport" NARROW [GOC:mah]
synonym: "triiodothyronine transport" NARROW [GOC:mah]
is_a: GO:0009914 ! hormone transport

[Term]
id: GO:0070328
name: triglyceride homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
synonym: "triacylglycerol homeostasis" EXACT [GOC:rl]
is_a: GO:0055090 ! acylglycerol homeostasis

[Term]
id: GO:0070329
name: tRNA seleno-modification
namespace: biological_process
def: "The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule." [GOC:jsg, PMID:14594807]
synonym: "tRNA base modification to selenouridine" EXACT [GOC:mah]
is_a: GO:0001887 ! selenium compound metabolic process
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0070330
name: aromatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone." [EC:1.14.14.14]
synonym: "estrogen synthetase activity" NARROW []
xref: EC:1.14.14.14
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0070331
name: CD20-Lck-Fyn complex
namespace: cellular_component
def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn." [GOC:mah, PMID:7545683]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0070332
name: CD20-Lck-Lyn-Fyn complex
namespace: cellular_component
def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn." [GOC:mah, PMID:7545683]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0070333
name: alpha6-beta4 integrin-Shc-Grb2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2." [PMID:7556090]
synonym: "ITGA6-ITGB4-SHC-GRB2 complex" NARROW [CORUM:3096]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070334
name: alpha6-beta4 integrin-laminin 5 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5." [GOC:mah, PMID:7556090]
synonym: "alpha6-beta4 integrin-laminin-332 complex" EXACT [GOC:sl, PMID:15979864]
synonym: "ITGA6-ITGB4-LAMA5 complex" NARROW [CORUM:2322]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070335
name: aspartate binding
namespace: molecular_function
def: "Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4." [CHEBI:29995, GOC:mah]
synonym: "aspartic acid binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0070336
name: flap-structured DNA binding
namespace: molecular_function
def: "Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0070337
name: 3'-flap-structured DNA binding
namespace: molecular_function
def: "Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154]
is_a: GO:0070336 ! flap-structured DNA binding

[Term]
id: GO:0070338
name: 5'-flap-structured DNA binding
namespace: molecular_function
def: "Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers." [GOC:mah, PMID:15189154]
is_a: GO:0070336 ! flap-structured DNA binding

[Term]
id: GO:0070339
name: response to bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:add, PMID:12077222]
is_a: GO:0032493 ! response to bacterial lipoprotein

[Term]
id: GO:0070340
name: detection of bacterial lipopeptide
namespace: biological_process
def: "The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal." [GOC:add, PMID:12077222]
is_a: GO:0042494 ! detection of bacterial lipoprotein
is_a: GO:0070339 ! response to bacterial lipopeptide

[Term]
id: GO:0070341
name: fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl]
synonym: "adipocyte proliferation" EXACT [GOC:sl]
synonym: "adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0070342
name: brown fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species." [CL:0000449, GOC:mah, GOC:sl]
synonym: "brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070343
name: white fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population." [CL:0000448, GOC:mah, GOC:sl]
synonym: "white adipocyte proliferation" EXACT [GOC:sl]
synonym: "white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070344
name: regulation of fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070345
name: negative regulation of fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: negatively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070346
name: positive regulation of fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: positively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070347
name: regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070348
name: negative regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070345 ! negative regulation of fat cell proliferation
is_a: GO:0070347 ! regulation of brown fat cell proliferation
relationship: negatively_regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070349
name: positive regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of brown adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of brown fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0070346 ! positive regulation of fat cell proliferation
is_a: GO:0070347 ! regulation of brown fat cell proliferation
relationship: positively_regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070350
name: regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070351
name: negative regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of white fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070345 ! negative regulation of fat cell proliferation
is_a: GO:0070350 ! regulation of white fat cell proliferation
relationship: negatively_regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070352
name: positive regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of white fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of white adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of white fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of white fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0070346 ! positive regulation of fat cell proliferation
is_a: GO:0070350 ! regulation of white fat cell proliferation
relationship: positively_regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070353
name: GATA1-TAL1-TCF3-Lmo2 complex
namespace: cellular_component
def: "A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070354
name: GATA2-TAL1-TCF3-Lmo2 complex
namespace: cellular_component
def: "A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070355
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof)." [PMID:7654227]
synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)" NARROW [CORUM:1247]
synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex" NARROW [CORUM:1247]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070356
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof)." [PMID:7654227]
synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)" NARROW [CORUM:1244]
synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex" NARROW [CORUM:1244]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070357
name: alphav-beta3 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP)." [PMID:2277087, PMID:7691831]
synonym: "ITGB3-ITGAV-CD47 complex" NARROW [CORUM:2356]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070358
name: actin polymerization-dependent cell motility
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." [GOC:mah, PMID:15773977]
synonym: "cell motility by actin tail formation" EXACT [PMID:15773977]
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0070360
name: symbiont-mediated actin polymerization-dependent cell-to-cell migration in host
namespace: biological_process
alt_id: GO:0070359
def: "The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of actin at one pole of the symbiont cell. Some bacteria use host actin for migration from cell to cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mah, PMID:15773977, PMID:15981456, PMID:26021574, PMID:27997855, PMID:35285700]
synonym: "actin polymerization-dependent cell migration in host" BROAD []
synonym: "actin polymerization-dependent cell motility involved in migration of symbiont in host" RELATED []
synonym: "actin polymerization-dependent cell-to-cell migration in host" EXACT []
synonym: "migration of symbiont within host by polymerization of host actin" RELATED []
is_a: GO:0070358 ! actin polymerization-dependent cell motility
is_a: GO:0106259 ! symbiont-mediated cell-to-cell migration in host

[Term]
id: GO:0070365
name: hepatocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884]
synonym: "liver cell differentiation" EXACT [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0070366
name: regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070367
name: negative regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070368
name: positive regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl]
synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
relationship: positively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070369
name: beta-catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, PMID:9065401, PMID:9065402]
synonym: "beta-catenin-TCF4 complex" EXACT [PMID:9065401, PMID:9065402]
is_a: GO:0071664 ! catenin-TCF7L2 complex
is_a: GO:1990907 ! beta-catenin-TCF complex

[Term]
id: GO:0070370
name: cellular heat acclimation
namespace: biological_process
def: "Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp]
synonym: "cellular thermotolerance" EXACT [GOC:jp]
is_a: GO:0010286 ! heat acclimation
is_a: GO:0034605 ! cellular response to heat

[Term]
id: GO:0070371
name: ERK1 and ERK2 cascade
namespace: biological_process
def: "A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development." [PMID:20811974, PMID:23125017, PMID:28903453]
comment: Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases.
synonym: "ERK cascade" BROAD [GOC:add]
synonym: "ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "ERK1 cascade" NARROW [GOC:add]
synonym: "ERK1/2 cascade" EXACT [GOC:add]
synonym: "ERK2 cascade" NARROW [GOC:add]
synonym: "extracellular signal-regulated kinase 1/2 (ERK1/2) cascade" EXACT [PMID:20811974]
synonym: "extracellular signal-regulated kinase 1/2 cascade" EXACT [PMID:20811974]
synonym: "MAPK1 cascade" NARROW [GOC:add]
synonym: "MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0000165 ! MAPK cascade

[Term]
id: GO:0070372
name: regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "regulation of ERK cascade" BROAD [GOC:add]
synonym: "regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "regulation of MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0043408 ! regulation of MAPK cascade
relationship: regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070373
name: negative regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "down regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "down-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "downregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "inhibition of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "negative regulation of ERK cascade" BROAD [GOC:add]
synonym: "negative regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "negative regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "negative regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "negative regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "negative regulation of MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade
relationship: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070374
name: positive regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]
synonym: "activation of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "positive regulation of ERK cascade" BROAD [GOC:add]
synonym: "positive regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "positive regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "positive regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "positive regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "positive regulation of MAPK3 cascade" NARROW [GOC:add]
synonym: "stimulation of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "up regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "up-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "upregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade
relationship: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070375
name: ERK5 cascade
namespace: biological_process
def: "A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development." [PMID:16376520, PMID:16880823, PMID:20811974, PMID:23125017, PMID:28903453]
synonym: "big MAP kinase signaling cascade" EXACT [PMID:20811974]
synonym: "BMK cascade" EXACT [PMID:20811974]
synonym: "BMK signaling pathway" EXACT [GOC:mah]
synonym: "BMK signalling pathway" EXACT [GOC:mah]
synonym: "BMK1 cascade" EXACT [GOC:add]
synonym: "ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "extracellular signal-regulated kinase 5 cascade" EXACT [PMID:20811974]
synonym: "MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0000165 ! MAPK cascade

[Term]
id: GO:0070376
name: regulation of ERK5 cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "regulation of BMK cascade" EXACT [GOC:signaling]
synonym: "regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "regulation of MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0043408 ! regulation of MAPK cascade
relationship: regulates GO:0070375 ! ERK5 cascade

[Term]
id: GO:0070377
name: negative regulation of ERK5 cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "down regulation of BMK cascade" EXACT [GOC:mah]
synonym: "down-regulation of BMK cascade" EXACT [GOC:mah]
synonym: "downregulation of BMK cascade" EXACT [GOC:mah]
synonym: "inhibition of BMK cascade" NARROW [GOC:mah]
synonym: "negative regulation of BMK cascade" EXACT [GOC:signaling]
synonym: "negative regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "negative regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "negative regulation of MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0070376 ! regulation of ERK5 cascade
relationship: negatively_regulates GO:0070375 ! ERK5 cascade

[Term]
id: GO:0070378
name: positive regulation of ERK5 cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:mah]
synonym: "activation of BMK cascade" NARROW [GOC:mah]
synonym: "positive regulation of BMK cascade" EXACT [GOC:signaling]
synonym: "positive regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "positive regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "positive regulation of MAPK7 cascade" EXACT [GOC:add]
synonym: "stimulation of BMK cascade" NARROW [GOC:mah]
synonym: "up regulation of BMK cascade" EXACT [GOC:mah]
synonym: "up-regulation of BMK cascade" EXACT [GOC:mah]
synonym: "upregulation of BMK cascade" EXACT [GOC:mah]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0070376 ! regulation of ERK5 cascade
relationship: positively_regulates GO:0070375 ! ERK5 cascade

[Term]
id: GO:0070379
name: high mobility group box 1 binding
namespace: molecular_function
def: "Binding to high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461]
synonym: "HMGB1 binding" EXACT [GOC:add]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070380
name: high mobility group box 1 receptor activity
namespace: molecular_function
def: "Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, PMID:18431461]
synonym: "HMGB1 receptor activity" EXACT [GOC:add]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0070381
name: endosome to plasma membrane transport vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576]
synonym: "endosome to plasma membrane constitutive secretory pathway transport vesicle" EXACT []
synonym: "endosome-plasma membrane transport vesicle" EXACT [GOC:mah]
is_a: GO:0070382 ! exocytic vesicle

[Term]
id: GO:0070382
name: exocytic vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT []
synonym: "exocytotic vesicle" EXACT [GOC:kad]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0099503 ! secretory vesicle

[Term]
id: GO:0070383
name: DNA cytosine deamination
namespace: biological_process
def: "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue." [GOC:mah]
is_a: GO:0045006 ! DNA deamination

[Term]
id: GO:0070384
name: Harderian gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species." [GOC:hjd, PMID:16856596, PMID:7559104]
comment: Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages.
is_a: GO:0048732 ! gland development

[Term]
id: GO:0070385
name: egasyn-beta-glucuronidase complex
namespace: cellular_component
def: "A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum." [PMID:7744842]
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:0070386
name: procollagen-proline 4-dioxygenase complex, alpha(I) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline)." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type" EXACT [PMID:7753822]
synonym: "prolyl 4-hydroxylase complex (alpha(I)-type)" BROAD [CORUM:472]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070387
name: procollagen-proline 4-dioxygenase complex, alpha(II) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type" EXACT [PMID:7753822]
synonym: "prolyl 4-hydroxylase complex (alpha(II)-type)" BROAD [CORUM:473]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070388
name: procollagen-proline 4-dioxygenase complex, alpha(III) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform." [PMID:14500733]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type" EXACT [PMID:14500733]
synonym: "prolyl 4-hydroxylase complex (alpha(III)-type)" BROAD [CORUM:474]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070390
name: transcription export complex 2
namespace: cellular_component
def: "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829]
synonym: "Sac3-Thp1-Sus1-Sem1-Cdc31 complex" EXACT [PMID:17786152]
synonym: "TREX-2 complex" EXACT [GOC:dgf]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070391
name: response to lipoteichoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "response to LTA" EXACT [GOC:add]
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0070392
name: detection of lipoteichoic acid
namespace: biological_process
def: "The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "detection of LTA" EXACT [GOC:add]
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0070391 ! response to lipoteichoic acid

[Term]
id: GO:0070393
name: teichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues." [GOC:add, PMID:14665680]
synonym: "teichoic acid breakdown" EXACT [GOC:add]
synonym: "teichoic acid catabolism" EXACT [GOC:add]
synonym: "teichoic acid degradation" EXACT [GOC:add]
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0046374 ! teichoic acid metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0070394
name: lipoteichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "lipoteichoic acid metabolism" EXACT [GOC:add]
synonym: "LTA metabolic process" EXACT [GOC:add]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:0070395
name: lipoteichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "lipoteichoic acid anabolism" EXACT [GOC:add]
synonym: "lipoteichoic acid biosynthesis" EXACT [GOC:add]
synonym: "lipoteichoic acid formation" EXACT [GOC:add]
synonym: "lipoteichoic acid synthesis" EXACT [GOC:add]
synonym: "LTA biosynthetic process" BROAD [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:0070394 ! lipoteichoic acid metabolic process

[Term]
id: GO:0070396
name: lipoteichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680]
synonym: "lipoteichoic acid breakdown" EXACT [GOC:add]
synonym: "lipoteichoic acid catabolism" EXACT [GOC:add]
synonym: "lipoteichoic acid degradation" EXACT [GOC:add]
is_a: GO:0070393 ! teichoic acid catabolic process
is_a: GO:0070394 ! lipoteichoic acid metabolic process

[Term]
id: GO:0070397
name: wall teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "wall teichoic acid metabolism" EXACT [GOC:add]
synonym: "WTA metabolic process" EXACT [GOC:add]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:0070398
name: wall teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "wall teichoic acid anabolism" EXACT [GOC:add]
synonym: "wall teichoic acid biosynthesis" EXACT [GOC:add]
synonym: "wall teichoic acid formation" EXACT [GOC:add]
synonym: "wall teichoic acid synthesis" EXACT [GOC:add]
synonym: "WTA biosynthetic process" EXACT [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:0070397 ! wall teichoic acid metabolic process

[Term]
id: GO:0070399
name: wall teichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680]
synonym: "wall teichoic acid breakdown" EXACT [GOC:add]
synonym: "wall teichoic acid catabolism" EXACT [GOC:add]
synonym: "wall teichoic acid degradation" EXACT [GOC:add]
is_a: GO:0070397 ! wall teichoic acid metabolic process

[Term]
id: GO:0070400
name: teichoic acid D-alanylation
namespace: biological_process
def: "The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "teichoic acid alanylation" EXACT [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process

[Term]
id: GO:0070401
name: NADP+ binding
namespace: molecular_function
def: "Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NADP (oxidized) binding" EXACT [GOC:mah]
synonym: "NADP binding" RELATED [GOC:mah]
synonym: "oxidized NADP binding" EXACT [GOC:mah]
synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0050661 ! NADP binding

[Term]
id: GO:0070402
name: NADPH binding
namespace: molecular_function
def: "Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NADP (reduced) binding" EXACT [GOC:mah]
synonym: "reduced NADP binding" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0050661 ! NADP binding

[Term]
id: GO:0070403
name: NAD+ binding
namespace: molecular_function
def: "Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NAD (oxidized) binding" EXACT [GOC:mah]
synonym: "NAD binding" RELATED [GOC:mah]
synonym: "oxidized NAD binding" EXACT [GOC:mah]
synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0051287 ! NAD binding

[Term]
id: GO:0070404
name: NADH binding
namespace: molecular_function
def: "Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NAD (reduced) binding" EXACT [GOC:mah]
synonym: "reduced NAD binding" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0051287 ! NAD binding

[Term]
id: GO:0070405
name: ammonium ion binding
namespace: molecular_function
def: "Binding to ammonium ions (NH4+)." [CHEBI:28938, GOC:ecd]
synonym: "ammonium binding" RELATED []
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0070406
name: glutamine binding
namespace: molecular_function
def: "Binding to glutamine, 2,5-diamino-5-oxopentanoic acid." [CHEBI:28300, GOC:ecd]
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0070407
name: oxidation-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein." [GOC:mah]
synonym: "oxidation-dependent protein breakdown" EXACT [GOC:mah]
synonym: "oxidation-dependent protein catabolism" EXACT [GOC:mah]
synonym: "oxidation-dependent protein degradation" EXACT [GOC:mah]
synonym: "oxidation-dependent proteolysis" EXACT [GOC:mah]
synonym: "oxidized protein catabolic process" EXACT [GOC:mah]
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0070408
name: carbamoyl phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph]
synonym: "carbamoyl phosphate metabolism" EXACT [GOC:mah]
xref: UM-BBD_pathwayID:bzn
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0070409
name: carbamoyl phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph]
synonym: "carbamoyl phosphate anabolism" EXACT []
synonym: "carbamoyl phosphate biosynthesis" EXACT []
synonym: "carbamoyl phosphate formation" EXACT []
synonym: "carbamoyl phosphate synthesis" EXACT []
synonym: "carbamyl phosphate biosynthetic process" EXACT [GOC:rph]
is_a: GO:0070408 ! carbamoyl phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0070410
name: co-SMAD binding
namespace: molecular_function
def: "Binding to a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
synonym: "common mediator SMAD binding" EXACT [GOC:rl]
synonym: "common partner SMAD binding" EXACT [GOC:rl]
synonym: "common-mediator SMAD binding" EXACT [GOC:rl]
synonym: "common-partner SMAD binding" EXACT [GOC:rl]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070411
name: I-SMAD binding
namespace: molecular_function
def: "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070412
name: R-SMAD binding
namespace: molecular_function
def: "Binding to a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
synonym: "pathway restricted SMAD binding" EXACT [GOC:rl]
synonym: "pathway-restricted SMAD binding" EXACT [GOC:rl]
synonym: "receptor regulated SMAD binding" EXACT [GOC:rl]
synonym: "receptor-regulated SMAD binding" EXACT [GOC:rl]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070413
name: trehalose metabolism in response to stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0005991 ! trehalose metabolic process
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0070414
name: trehalose metabolism in response to heat stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to heat stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0070413 ! trehalose metabolism in response to stress
relationship: part_of GO:0034605 ! cellular response to heat

[Term]
id: GO:0070415
name: trehalose metabolism in response to cold stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to cold stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0070413 ! trehalose metabolism in response to stress
is_a: GO:0070417 ! cellular response to cold

[Term]
id: GO:0070416
name: trehalose metabolism in response to water deprivation
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to water deprivation" EXACT systematic_synonym [GOC:mah]
is_a: GO:0070413 ! trehalose metabolism in response to stress
relationship: part_of GO:0009414 ! response to water deprivation

[Term]
id: GO:0070417
name: cellular response to cold
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp]
synonym: "cellular response to cold stress" EXACT [GOC:jp]
is_a: GO:0009409 ! response to cold
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0070418
name: DNA-dependent protein kinase complex
namespace: cellular_component
def: "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392]
synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW []
synonym: "DNA-PK complex" EXACT []
synonym: "DNA-PK-Ku antigen complex" EXACT [CORUM:355]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0070419
name: nonhomologous end joining complex
namespace: cellular_component
def: "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628]
synonym: "NHEJ complex" EXACT [GOC:mah]
synonym: "non-homologous end joining complex" EXACT [GOC:mah]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990391 ! DNA repair complex

[Term]
id: GO:0070420
name: Ku-DNA ligase complex
namespace: cellular_component
def: "A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria." [GOC:mah, PMID:17938628]
is_a: GO:0070419 ! nonhomologous end joining complex

[Term]
id: GO:0070421
name: DNA ligase III-XRCC1 complex
namespace: cellular_component
def: "A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair." [PMID:15141024, PMID:7760816]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0070422
name: G-protein beta/gamma-Raf-1 complex
namespace: cellular_component
def: "A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7782277]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G protein complex (GNG2, GNB2L1, RAF1)" RELATED [CORUM:1539]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0070423
name: obsolete nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing (NOD) protein receptor, and ending with regulation of a downstream cellular process." [GOC:add, PMID:17944960, PMID:18585455]
comment: This term was obsoleted because it is an unnecessary grouoing term.
synonym: "NOD signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0035872

[Term]
id: GO:0070424
name: regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway." [GOC:add]
synonym: "regulation of NOD signaling pathway" NARROW [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing signaling pathway" NARROW []
synonym: "regulation of nucleotide-binding oligomerization domain containing signalling pathway" NARROW [GOC:mah]
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

[Term]
id: GO:0070425
name: negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway." [GOC:add]
synonym: "negative regulation of NOD signaling pathway" NARROW [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing signaling pathway" NARROW []
synonym: "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" NARROW [GOC:mah]
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0070424 ! regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
relationship: negatively_regulates GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

[Term]
id: GO:0070426
name: positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway." [GOC:add]
synonym: "positive regulation of NOD signaling pathway" NARROW [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing signaling pathway" NARROW []
synonym: "positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" NARROW [GOC:mah]
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:0070424 ! regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

[Term]
id: GO:0070427
name: nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD1 signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

[Term]
id: GO:0070428
name: regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070424 ! regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
relationship: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070429
name: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "negative regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070425 ! negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
relationship: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070430
name: positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "positive regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070426 ! positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
relationship: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070431
name: nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD2 signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

[Term]
id: GO:0070432
name: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070424 ! regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
relationship: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070433
name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "negative regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070425 ! negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
relationship: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070434
name: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "positive regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070426 ! positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
relationship: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070435
name: Shc-EGFR complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Shc-Egfr complex, EGF stimulated" NARROW [CORUM:2887]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070436
name: Grb2-EGFR complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Grb2-Egfr complex, EGF stimulated" NARROW [CORUM:2889]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070437
name: Grb2-Shc complex
namespace: cellular_component
def: "A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Grb2-Shc complex, EGF stimulated" NARROW [CORUM:2888]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070438
name: obsolete mTOR-FKBP12-rapamycin complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus)." [GOC:sl, PMID:20005306, PMID:7822316]
comment: This term was made obsolete because it describes a complex with a drug bound, with the drug being exogenous to the species where the experiment takes place and where that interaction would never occur naturally.
synonym: "Fkbp1a-Frap1 complex" NARROW [CORUM:2987]
synonym: "mTOR-FKBP12-rapamycin complex" EXACT []
is_obsolete: true

[Term]
id: GO:0070439
name: Mad-Max-mSin3A complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p." [PMID:7889570]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070440
name: Mad-Max-mSin3B complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p." [PMID:7889570]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070441
name: G-protein beta/gamma-Btk complex
namespace: cellular_component
def: "A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7972043]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G protein complex (BTK, GNG1, GNG2)" RELATED [CORUM:1615]
synonym: "G protein complex (Btk, Gng2, Gnb1)" RELATED [CORUM:3195]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0070442
name: integrin alphaIIb-beta3 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaIIb subunit and one beta3 subunit." [PMID:12297042]
synonym: "alphaIIb-beta3 integrin complex" EXACT []
synonym: "ITGA2B-ITGB3 complex" NARROW [CORUM:2381]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0070443
name: Mad-Max complex
namespace: cellular_component
def: "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max." [PMID:8224841]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070444
name: oligodendrocyte progenitor proliferation
namespace: biological_process
def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915]
synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0070445
name: regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
relationship: regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070446
name: negative regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
relationship: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070447
name: positive regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
relationship: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070448
name: laricitrin 5'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin." [RHEA:25633]
synonym: "CrCOMT2" RELATED []
synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED []
synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED []
xref: KEGG_REACTION:R06816
xref: MetaCyc:RXN-8452
xref: RHEA:25633
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0070449
name: elongin complex
namespace: cellular_component
def: "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794]
comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
synonym: "elongin (SIII) complex" EXACT [CORUM:56]
synonym: "transcription elongation factor SIII complex" EXACT [PMID:8244996]
synonym: "transcription factor B (SIII) complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0070450
name: interleukin4-interleukin-4 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule." [GOC:mah, PMID:10358772]
synonym: "IL4-IL4 receptor complex" EXACT [GOC:mah]
synonym: "IL4-IL4R-IL2RG complex" NARROW [CORUM:1515]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070451
name: cell hair
namespace: cellular_component
def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084]
synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah]
synonym: "non-sensory hair" EXACT [GOC:bf]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0070452
name: positive regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah]
synonym: "activation of ergosterol biosynthetic process" NARROW []
synonym: "positive regulation of ergosterol anabolism" EXACT []
synonym: "positive regulation of ergosterol biosynthesis" EXACT []
synonym: "positive regulation of ergosterol formation" EXACT []
synonym: "positive regulation of ergosterol synthesis" EXACT []
synonym: "stimulation of ergosterol biosynthetic process" NARROW []
synonym: "up regulation of ergosterol biosynthetic process" EXACT []
synonym: "up-regulation of ergosterol biosynthetic process" EXACT []
synonym: "upregulation of ergosterol biosynthetic process" EXACT []
is_a: GO:0032443 ! regulation of ergosterol biosynthetic process
is_a: GO:0106120 ! positive regulation of sterol biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0070453
name: regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
synonym: "regulation of haem biosynthesis" EXACT [GOC:mah]
synonym: "regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of heme anabolism" EXACT [GOC:mah]
synonym: "regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "regulation of heme formation" EXACT [GOC:mah]
synonym: "regulation of heme synthesis" EXACT [GOC:mah]
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
relationship: regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070454
name: negative regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
synonym: "down regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of heme biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "negative regulation of heme anabolism" EXACT [GOC:mah]
synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of heme formation" EXACT [GOC:mah]
synonym: "negative regulation of heme synthesis" EXACT [GOC:mah]
is_a: GO:0070453 ! regulation of heme biosynthetic process
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
relationship: negatively_regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070455
name: positive regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
synonym: "activation of heme biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "positive regulation of heme anabolism" EXACT [GOC:mah]
synonym: "positive regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of heme formation" EXACT [GOC:mah]
synonym: "positive regulation of heme synthesis" EXACT [GOC:mah]
synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah]
is_a: GO:0070453 ! regulation of heme biosynthetic process
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
relationship: positively_regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070456
name: galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate." [GOC:mah]
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0070457
name: D-galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate." [GOC:mah, PMID:9462881]
is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity

[Term]
id: GO:0070458
name: cellular detoxification of nitrogen compound
namespace: biological_process
def: "Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:mah]
synonym: "cellular detoxification of nitrogenous compound" EXACT [GOC:mah]
is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:1990748 ! cellular detoxification
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0070459
name: prolactin secretion
namespace: biological_process
def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732]
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070460
name: thyroid-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732]
synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah]
synonym: "TSH secretion" EXACT []
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070461
name: SAGA-type complex
namespace: cellular_component
def: "A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]
synonym: "SAGA family complex" EXACT [PMID:17337012]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0070462
name: plus-end specific microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148]
is_a: GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0070463
name: tubulin-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate." [GOC:mah, PMID:16906148]
synonym: "tubulin-activated ATPase activity" EXACT []
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0070464
name: alphav-beta3 integrin-collagen alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen." [PMID:8387021]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070465
name: alpha1-beta1 integrin-alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021]
synonym: "ITGA1-ITGB1-COL6A3 complex" NARROW [CORUM:2434]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070466
name: alpha2-beta1 integrin-alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021]
synonym: "ITGA2-ITGB1-COL6A3 complex" NARROW [CORUM:2431]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070467
name: RC-1 DNA recombination complex
namespace: cellular_component
def: "A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA." [PMID:8392064, PMID:8670910]
synonym: "DNA recombination complex RC-1" EXACT [GOC:mah]
synonym: "RC-1 complex (recombination complex 1)" EXACT [CORUM:364]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070468
name: dentin extracellular matrix secretion
namespace: biological_process
def: "The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin." [GOC:mah, PMID:12856968]
synonym: "dentin secretion" RELATED []
synonym: "dentine secretion" RELATED [GOC:mah]
synonym: "predentin secretion" RELATED []
is_a: GO:0070278 ! extracellular matrix constituent secretion
relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0070469
name: obsolete respirasome
namespace: cellular_component
def: "OBSOLETE. The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684, Wikipedia:Respirasome]
comment: The reason for obsoletion is that this term is equivalent to respiratory chain complex.
synonym: "membrane electron transport chain" EXACT [GOC:mah]
synonym: "respiratory chain" EXACT []
is_obsolete: true
replaced_by: GO:0098803

[Term]
id: GO:0070470
name: obsolete plasma membrane respirasome
namespace: cellular_component
def: "OBSOLETE. A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:imk, GOC:mah, ISBN:0198547684]
comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
synonym: "plasma membrane electron transport chain" EXACT [GOC:mah]
synonym: "plasma membrane respiratory chain" EXACT []
is_obsolete: true
replaced_by: GO:0098803

[Term]
id: GO:0070471
name: uterine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth." [GOC:sl]
synonym: "myometrial contraction" EXACT [GOC:sl]
synonym: "myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "myometrium contraction" EXACT [GOC:sl]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0070472
name: regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "regulation of myometrium contraction" EXACT [GOC:sl]
is_a: GO:0006940 ! regulation of smooth muscle contraction
relationship: regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070473
name: negative regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "down-regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "downregulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "inhibition of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "negative regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "negative regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "negative regulation of myometrium contraction" EXACT [GOC:sl]
synonym: "uterine smooth muscle relaxation" RELATED [GOC:mah]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0070472 ! regulation of uterine smooth muscle contraction
relationship: negatively_regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070474
name: positive regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "activation of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "positive regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "positive regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "positive regulation of myometrium contraction" EXACT [GOC:sl]
synonym: "stimulation of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "up regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "up-regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "upregulation of uterine smooth muscle contraction" EXACT [GOC:mah]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:0070472 ! regulation of uterine smooth muscle contraction
relationship: positively_regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070475
name: rRNA base methylation
namespace: biological_process
def: "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0070476
name: rRNA (guanine-N7)-methylation
namespace: biological_process
def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah]
is_a: GO:0036265 ! RNA (guanine-N7)-methylation
is_a: GO:0070475 ! rRNA base methylation

[Term]
id: GO:0070477
name: endospore core
namespace: cellular_component
def: "An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive." [GOC:mah, PMID:15035041, PMID:18035610]
is_a: GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0070478
name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863]
synonym: "3'-5' NMD" EXACT [GOC:jp]
synonym: "3'-5' nonsense-mediated decay" EXACT [GOC:jp]
synonym: "3'-5' nonsense-mediated mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

[Term]
id: GO:0070479
name: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [PMID:18554525]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "5'-3' NMD" EXACT [GOC:jp]
synonym: "5'-3' nonsense-mediated decay" EXACT [GOC:jp]
synonym: "5'-3' nonsense-mediated mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

[Term]
id: GO:0070480
name: obsolete exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs independent of deadenylation, but requires decapping followed by transcript decay." [GOC:jp]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0031086

[Term]
id: GO:0070481
name: nuclear-transcribed mRNA catabolic process, non-stop decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon." [PMID:11910110]
synonym: "non-stop decay" EXACT [GOC:jp]
synonym: "non-stop mRNA decay" EXACT [GOC:jp]
synonym: "nonstop mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, non-stop decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, non-stop decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, non-stop decay" EXACT [GOC:mah]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0070482
name: response to oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0070483
name: detection of hypoxia
namespace: biological_process
def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah]
synonym: "detection of reduced oxygen levels" EXACT [GOC:vk]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0003032 ! detection of oxygen

[Term]
id: GO:0070484
name: dehydro-D-arabinono-1,4-lactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [GOC:cjk, GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah]
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:0070485
name: dehydro-D-arabinono-1,4-lactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [GOC:cjk, GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah]
is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0070486
name: leukocyte aggregation
namespace: biological_process
def: "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "immune cell aggregation" EXACT [CL:0000738]
synonym: "leucocyte aggregation" EXACT [CL:0000738, GOC:sl]
synonym: "white blood cell aggregation" EXACT [CL:0000738, GOC:sl]
synonym: "white corpuscle aggregation" EXACT [GOC:sl]
is_a: GO:0007159 ! leukocyte cell-cell adhesion

[Term]
id: GO:0070487
name: monocyte aggregation
namespace: biological_process
def: "The adhesion of one monocyte to one or more other monocytes via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "mononuclear phagocyte aggregation" EXACT [GOC:sl]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0070488
name: neutrophil aggregation
namespace: biological_process
def: "The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "neutrocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophil leucocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophil leukocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophilic leucocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophilic leukocyte aggregation" EXACT [CL:0000775, GOC:mah]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0070489
name: T cell aggregation
namespace: biological_process
def: "The adhesion of one T cell to one or more other T cells via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "T lymphocyte aggregation" EXACT [CL:0000084, GOC:sl]
synonym: "T-cell aggregation" EXACT [CL:0000084, GOC:mah]
synonym: "T-lymphocyte aggregation" EXACT [CL:0000084, GOC:mah]
is_a: GO:0071593 ! lymphocyte aggregation

[Term]
id: GO:0070490
name: protein pupylation
namespace: biological_process
def: "The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein." [PMID:18980670]
synonym: "Pup-protein conjugation" EXACT [GOC:mah]
synonym: "pupylation" EXACT [GOC:mah]
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0070492
name: oligosaccharide binding
namespace: molecular_function
def: "Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0070493
name: thrombin-activated receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, PMID:1672265]
synonym: "thrombin receptor signaling pathway" EXACT []
synonym: "thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0070494
name: regulation of thrombin-activated receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a thrombin-activated receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "regulation of thrombin receptor signaling pathway" EXACT []
synonym: "regulation of thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0070493 ! thrombin-activated receptor signaling pathway

[Term]
id: GO:0070495
name: negative regulation of thrombin-activated receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "negative regulation of thrombin receptor signaling pathway" EXACT []
synonym: "negative regulation of thrombin receptor signalling pathway" RELATED [GOC:mah]
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:0070494 ! regulation of thrombin-activated receptor signaling pathway
relationship: negatively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway

[Term]
id: GO:0070496
name: positive regulation of thrombin-activated receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "positive regulation of thrombin receptor signaling pathway" EXACT []
synonym: "positive regulation of thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:0070494 ! regulation of thrombin-activated receptor signaling pathway
relationship: positively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway

[Term]
id: GO:0070497
name: 6-carboxytetrahydropterin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+." [GOC:imk, PMID:19231875, RHEA:27966]
synonym: "6-carboxy-5,6,7,8-tetrahydropterin synthase activity" EXACT []
xref: EC:4.1.2.50
xref: MetaCyc:RXN0-5507
xref: RHEA:27966
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0070498
name: interleukin-1-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "IL-1 alpha-mediated signaling pathway" NARROW [GOC:add]
synonym: "IL-1 beta-mediated signaling pathway" NARROW [GOC:add]
synonym: "IL-1-mediated signaling pathway" EXACT [GOC:mah]
synonym: "interleukin-1 alpha-mediated signaling pathway" NARROW [GOC:add]
synonym: "interleukin-1 beta-mediated signaling pathway" NARROW [GOC:add]
synonym: "interleukin-1-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071347 ! cellular response to interleukin-1

[Term]
id: GO:0070499
name: exosporium assembly
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore." [GOC:mah]
synonym: "exosporium formation" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0070500
name: obsolete poly-gamma-glutamate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787]
comment: This term was obsoleted because it represents a molecular function.
synonym: "poly-gamma-glutamate metabolism" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0034722

[Term]
id: GO:0070501
name: poly-gamma-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787]
synonym: "poly-gamma-glutamate anabolism" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate biosynthesis" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate formation" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate synthesis" EXACT [GOC:mah]
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0070502
name: capsule poly-gamma-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule." [GOC:mah, PMID:16689787]
synonym: "capsular poly-gamma-glutamate biosynthetic process" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate anabolism" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate biosynthesis" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate formation" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate synthesis" EXACT [GOC:mah]
is_a: GO:0045230 ! capsule organization
is_a: GO:0070501 ! poly-gamma-glutamate biosynthetic process

[Term]
id: GO:0070503
name: selenium-containing prosthetic group metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah]
synonym: "selenium-containing prosthetic group metabolism" EXACT [GOC:mah]
is_a: GO:0001887 ! selenium compound metabolic process
is_a: GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0070504
name: selenium-containing prosthetic group biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah]
synonym: "selenium-containing prosthetic group anabolism" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group biosynthesis" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group formation" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group synthesis" EXACT [GOC:mah]
is_a: GO:0051191 ! prosthetic group biosynthetic process
is_a: GO:0070503 ! selenium-containing prosthetic group metabolic process

[Term]
id: GO:0070505
name: pollen coat
namespace: cellular_component
def: "A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma." [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271]
synonym: "pollenkitt" EXACT [PMID:15012271]
synonym: "tryphine" EXACT [PMID:15012271]
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0070506
name: high-density lipoprotein particle receptor activity
namespace: molecular_function
def: "Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis." [GOC:bf, GOC:BHF, GOC:rl, PMID:9211901]
synonym: "HDL receptor" EXACT [GOC:rl]
synonym: "high-density lipoprotein receptor activity" EXACT [GOC:dph]
is_a: GO:0030228 ! lipoprotein particle receptor activity

[Term]
id: GO:0070507
name: regulation of microtubule cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: regulates GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0070508
name: cholesterol import
namespace: biological_process
def: "The directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:rl]
synonym: "cholesterol uptake" EXACT [GOC:rl]
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0070509
name: calcium ion import
namespace: biological_process
def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah]
synonym: "calcium ion uptake" EXACT [GOC:mah]
synonym: "transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0070510
name: obsolete regulation of histone H4-K20 methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
comment: This term was obsoleted because it represents regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:0070511
name: obsolete negative regulation of histone H4-K20 methylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
comment: This term was obsoleted because it represents ergulation of a molecular function.
synonym: "down regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "down-regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "downregulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "inhibition of histone H4-K20 methylation" NARROW [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070512
name: obsolete positive regulation of histone H4-K20 methylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H4-K20 methylation" NARROW [GOC:mah]
synonym: "stimulation of histone H4-K20 methylation" NARROW [GOC:mah]
synonym: "up regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "up-regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "upregulation of histone H4-K20 methylation" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070513
name: death domain binding
namespace: molecular_function
def: "Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]
comment: For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'.
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070514
name: SRF-myogenin-E12 complex
namespace: cellular_component
def: "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes." [PMID:8617811]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0070515
name: alphaIIb-beta3 integrin-talin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin." [PMID:8663236]
synonym: "ITGA2b-ITGB3-TLN1 complex" NARROW [CORUM:2378]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070516
name: CAK-ERCC2 complex
namespace: cellular_component
def: "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842]
synonym: "cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex" EXACT [GOC:mah]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070517
name: DNA replication factor C core complex
namespace: cellular_component
def: "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37." [PMID:8692848, PMID:9228079, PMID:9582326]
synonym: "RFC core complex" EXACT [CORUM:278]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043599 ! nuclear DNA replication factor C complex

[Term]
id: GO:0070518
name: alpha4-beta1 integrin-CD53 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family." [PMID:8757325]
synonym: "ITGA4-ITGB1-CD53 complex" NARROW [CORUM:2420]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070519
name: alpha4-beta1 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8757325]
synonym: "ITGA4-ITGB1-CD63 complex" NARROW [CORUM:2424]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070520
name: alpha4-beta1 integrin-CD81 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family." [PMID:10229664, PMID:8757325]
synonym: "ITGA4-ITGB1-CD81 complex" NARROW [CORUM:2419]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070521
name: alpha4-beta1 integrin-CD82 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family." [PMID:8757325]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070522
name: ERCC4-ERCC1 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "Rad1-Rad10 complex" EXACT [GOC:mah]
synonym: "XPF-ERCC1 complex" EXACT [PMID:14734547]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070523
name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036, RHEA:53116]
xref: RHEA:53116
xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0070524
name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [PMID:16216911, RHEA:11388]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD []
synonym: "corticosteroid 11-beta-dehydrogenase activity" RELATED [EC:1.1.1.146]
xref: EC:1.1.1.146
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
xref: Reactome:R-HSA-9757706 "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell"
xref: Reactome:R-HSA-9759259 "HSD11B2 dehydrogenates PREDL to PREDN"
xref: RHEA:11388
xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0070525
name: tRNA threonylcarbamoyladenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]
synonym: "t6A metabolic process" EXACT [PMID:19287007]
synonym: "t6A metabolism" EXACT [PMID:19287007]
synonym: "threonylcarbamoyladenosine metabolism" EXACT [GOC:MAH]
is_a: GO:0006399 ! tRNA metabolic process

[Term]
id: GO:0070527
name: platelet aggregation
namespace: biological_process
def: "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk]
synonym: "blood platelet aggregation" EXACT [CL:0000233]
synonym: "thrombocyte aggregation" RELATED [CL:0000233]
is_a: GO:0034109 ! homotypic cell-cell adhesion
relationship: part_of GO:0030168 ! platelet activation

[Term]
id: GO:0070528
name: protein kinase C signaling
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:mah]
synonym: "PKC signal transduction" EXACT [GOC:signaling]
synonym: "PKC signaling cascade" RELATED [GOC:mah]
synonym: "protein kinase C signal transduction" EXACT [GOC:signaling]
synonym: "protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "protein kinase C signalling cascade" RELATED [GOC:mah]
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0070529
name: L-tryptophan aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070530
name: K63-linked polyubiquitin modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341]
is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding

[Term]
id: GO:0070531
name: BRCA1-A complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070532
name: BRCA1-B complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites." [GOC:mah, PMID:16391231]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070533
name: BRCA1-C complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070534
name: protein K63-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]
synonym: "protein K63-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0070535
name: obsolete histone H2A K63-linked ubiquitination
namespace: biological_process
def: "OBSOLETE. A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:18430235]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0070536
name: protein K63-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0070537
name: obsolete histone H2A K63-linked deubiquitination
namespace: biological_process
def: "OBSOLETE. A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:19202061, PMID:19214193]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0070538
name: oleic acid binding
namespace: molecular_function
def: "Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid." [GOC:lp, GOC:mah]
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0070539
name: linoleic acid binding
namespace: molecular_function
def: "Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid." [GOC:lp, GOC:mah]
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0070540
name: stearic acid binding
namespace: molecular_function
def: "Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid." [GOC:lp, GOC:mah]
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0070541
name: response to platinum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:sl]
synonym: "response to platinum" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0070542
name: response to fatty acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:lp]
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0070543
name: response to linoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:lp]
synonym: "response to linoleate" EXACT [GOC:mah]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0070544
name: obsolete histone H3-K36 demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone." [GOC:sart, PMID:19061644]
comment: This term was obsoleted because it represents a molecular function.
synonym: "H3K36 demethylation" RELATED []
is_obsolete: true

[Term]
id: GO:0070545
name: PeBoW complex
namespace: cellular_component
def: "A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005730 ! nucleolus
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0070546
name: obsolete L-phenylalanine transaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "L-phenylalanine aminotransferase activity" EXACT []
is_obsolete: true
consider: GO:0047312
consider: GO:0080130

[Term]
id: GO:0070547
name: obsolete L-tyrosine aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
consider: GO:0004838
consider: GO:0080098

[Term]
id: GO:0070548
name: L-glutamine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070549
name: siRNA-mediated gene silencing by inhibition of translation
namespace: biological_process
def: "An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs." [GOC:mah, PMID:18771919]
synonym: "down regulation of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "down-regulation of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "downregulation of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "inhibition of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "negative regulation of translation involved in RNA interference" BROAD []
synonym: "RNA interference, negative regulation of translation" EXACT [GOC:mah]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0140766 ! siRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0070550
name: rDNA chromatin condensation
namespace: biological_process
def: "The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase." [GOC:dgf, PMID:10811823, PMID:15137940]
synonym: "rDNA condensation" EXACT []
synonym: "rDNA packaging" EXACT []
is_a: GO:0030261 ! chromosome condensation
relationship: part_of GO:1990700 ! nucleolar chromatin organization

[Term]
id: GO:0070551
name: endoribonuclease activity, cleaving siRNA-paired mRNA
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters." [GOC:mah, PMID:15105377]
synonym: "argonaute endoribonuclease activity" RELATED [GOC:mah]
xref: Reactome:R-HSA-9820842 "AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote"
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0070552
name: BRISC complex
namespace: cellular_component
def: "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070553
name: nicotinic acid receptor activity
namespace: molecular_function
def: "Combining with nicotinic acid to initiate a change in cell activity." [GOC:mah, PMID:12522134]
synonym: "niacin receptor activity" EXACT [CHEBI:15940, GOC:mah]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0070554
name: synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof)." [PMID:8824312]
synonym: "SNARE complex (Stx3, Snap25, Vamp2, Cplx1)" NARROW [CORUM:842]
synonym: "Stx3-Snap25-Vamp2-Cplx1 complex" NARROW [CORUM:842]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070555
name: response to interleukin-1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-1" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070556
name: TAF4B-containing transcription factor TFIID complex
namespace: cellular_component
def: "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4." [GOC:mah, PMID:8858156]
synonym: "TFIID complex, B-cell specific" RELATED [CORUM:485]
is_a: GO:0005669 ! transcription factor TFIID complex

[Term]
id: GO:0070557
name: PCNA-p21 complex
namespace: cellular_component
def: "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070558
name: alphaM-beta2 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8871662]
synonym: "ITGAM-ITGB2-CD63 complex" NARROW [CORUM:2153]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070559
name: lysosomal multienzyme complex
namespace: cellular_component
def: "A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism." [GOC:mah, PMID:8910459]
synonym: "GALNS-lysosomal hydrolase 1.27 MDa complex" NARROW [CORUM:1379]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0070560
name: protein secretion by platelet
namespace: biological_process
def: "The regulated release of proteins by a platelet or group of platelets." [GOC:BHF, GOC:mah]
is_a: GO:0009306 ! protein secretion
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0070561
name: vitamin D receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by vitamin D binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, PMID:12637589]
synonym: "calcitriol signaling pathway" NARROW [GOC:bf]
synonym: "intracellular vitamin D receptor signaling pathway" EXACT []
synonym: "nuclear receptor-mediated vitamin D signaling pathway" EXACT []
synonym: "VDR signaling pathway" EXACT [PMID:12637589]
synonym: "vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0141193 ! nuclear receptor-mediated signaling pathway
relationship: part_of GO:0071305 ! cellular response to vitamin D

[Term]
id: GO:0070562
name: regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "regulation of VDR signaling pathway" EXACT [PMID:12637589]
synonym: "regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0070561 ! vitamin D receptor signaling pathway

[Term]
id: GO:0070563
name: negative regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "down regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "down-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "downregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "inhibition of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "negative regulation of VDR signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of VDR signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway

[Term]
id: GO:0070564
name: positive regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "activation of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "positive regulation of VDR signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah]
synonym: "stimulation of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "up regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "up-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "upregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway

[Term]
id: GO:0070565
name: telomere-telomerase complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome." [GOC:pde, PMID:19179534]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
is_a: GO:0032993 ! protein-DNA complex
relationship: part_of GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0070566
name: adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070567
name: cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070568
name: guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070569
name: uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]
synonym: "uridyl transferase activity" EXACT []
synonym: "uridyltransferase activity" EXACT []
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070570
name: regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0070571
name: negative regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
synonym: "growth cone collapse" RELATED [GOC:pr]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0070570 ! regulation of neuron projection regeneration
relationship: negatively_regulates GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0070572
name: positive regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0070570 ! regulation of neuron projection regeneration
relationship: positively_regulates GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0070573
name: metallodipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
synonym: "metallo-exo-dipeptidase activity" EXACT [GOC:rb]
synonym: "metalloexodipeptidase activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-2022398 "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)"
xref: Reactome:R-HSA-2022405 "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
xref: Reactome:R-HSA-2065355 "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
is_a: GO:0008235 ! metalloexopeptidase activity
is_a: GO:0016805 ! dipeptidase activity

[Term]
id: GO:0070574
name: cadmium ion transmembrane transport
namespace: biological_process
def: "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "cadmium ion membrane transport" EXACT []
synonym: "transmembrane cadmium transport" EXACT [GOC:mah]
is_a: GO:0015691 ! cadmium ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0070575
name: peptide mating pheromone maturation involved in regulation of pheromone-induced unidirectional conjugation
namespace: biological_process
def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation." [GOC:mah]
synonym: "peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
synonym: "peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
is_a: GO:0007323 ! peptide pheromone maturation
relationship: regulates GO:0000762 ! pheromone-induced unidirectional conjugation

[Term]
id: GO:0070576
name: vitamin D 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:mah, PMID:15546903]
synonym: "calciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "cholecalciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "ergocalciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D2 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D3 24-hydroxylase activity" NARROW [GOC:rl]
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0070577
name: lysine-acetylated histone binding
namespace: molecular_function
def: "Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]
synonym: "acetylated histone residue binding" BROAD [GOC:rl]
is_a: GO:0042393 ! histone binding
is_a: GO:0140033 ! acetylation-dependent protein binding

[Term]
id: GO:0070578
name: RISC-loading complex
namespace: cellular_component
def: "A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]
synonym: "microRNA loading complex" EXACT [GOC:ab]
synonym: "miRLC" EXACT [GOC:ab]
synonym: "RLC" RELATED [GOC:ab, GOC:mah]
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0070579
name: 5-methylcytosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC)." [PMID:19372391, PMID:21496894, PMID:21778364]
comment: This reaction removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system. Do not confuse with oxidative DNA demethylase activity ; GO:0035516, which directly reverses the alkylation on nucleodides in the DNA.
synonym: "methylcytosine dioxygenase activity" BROAD []
xref: EC:1.14.11.80
xref: Reactome:R-HSA-5220952 "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine"
xref: Reactome:R-HSA-5220990 "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine"
xref: Reactome:R-HSA-5221014 "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine"
xref: Reactome:R-HSA-9817458 "TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3"
xref: WIkipedia:DNA_demethylation
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0070580
name: base J metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J." [PMID:19114062]
synonym: "base J metabolism" EXACT [GOC:mah]
synonym: "beta-D-glucosyl-HOMedU metabolic process" EXACT [GOC:mah]
synonym: "beta-D-glucosyl-hydroxymethyluracil metabolism" EXACT [PMID:19114062]
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0070581
name: rolling circle DNA replication
namespace: biological_process
def: "A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon." [GOC:cb, GOC:mah, ISBN:0198506732]
synonym: "rolling circle replication" EXACT [GOC:cb]
is_a: GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0070582
name: theta DNA replication
namespace: biological_process
def: "A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template." [GOC:cb, GOC:mah, ISBN:0198506732]
synonym: "theta replication" EXACT [GOC:cb]
is_a: GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0070583
name: spore membrane bending pathway
namespace: biological_process
def: "The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore." [GOC:dgf, PMID:18756268]
synonym: "ascospore-type prospore membrane bending" EXACT [GOC:mah]
synonym: "forespore membrane bending" EXACT [GOC:mah]
synonym: "FSM bending" EXACT [GOC:mah]
is_a: GO:0061024 ! membrane organization
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0032120 ! ascospore-type prospore membrane formation

[Term]
id: GO:0070584
name: obsolete mitochondrion morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]
comment: This term is obsoleted because it is an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0007005

[Term]
id: GO:0070585
name: protein localization to mitochondrion
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]
synonym: "protein localisation in mitochondrion" EXACT [GOC:mah]
synonym: "protein localization in mitochondrion" EXACT []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0070586
name: cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0070587
name: regulation of cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation

[Term]
id: GO:0070588
name: calcium ion transmembrane transport
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "calcium ion membrane transport" EXACT []
synonym: "transmembrane calcium transport" EXACT [GOC:mah]
is_a: GO:0006816 ! calcium ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0070589
name: obsolete cellular component macromolecule biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "cellular component macromolecule biosynthesis" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070590
name: spore wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore." [GOC:mah]
is_a: GO:0042546 ! cell wall biogenesis
relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0070591
name: ascospore wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall." [GOC:mah]
is_a: GO:0009272 ! fungal-type cell wall biogenesis
is_a: GO:0070590 ! spore wall biogenesis
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0030437 ! ascospore formation

[Term]
id: GO:0070592
name: cell wall polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall." [GOC:mah]
synonym: "cell wall polysaccharide anabolism" EXACT [GOC:mah]
synonym: "cell wall polysaccharide biosynthesis" EXACT [GOC:mah]
synonym: "cell wall polysaccharide synthesis" EXACT [GOC:mah]
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0010383 ! cell wall polysaccharide metabolic process

[Term]
id: GO:0070593
name: dendrite self-avoidance
namespace: biological_process
def: "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
synonym: "dendrite repulsion" EXACT [GOC:sart]
is_a: GO:0008038 ! neuron recognition

[Term]
id: GO:0070594
name: juvenile hormone response element binding
namespace: molecular_function
def: "Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872]
synonym: "JHRE binding" EXACT [GOC:mah]
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0070595
name: (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0070596
name: (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan anabolism" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan biosynthesis" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan formation" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process

[Term]
id: GO:0070597
name: cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process

[Term]
id: GO:0070598
name: cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
is_a: GO:0070596 ! (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process

[Term]
id: GO:0070599
name: fungal-type cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process
is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process

[Term]
id: GO:0070600
name: fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process
is_a: GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process

[Term]
id: GO:0070601
name: centromeric sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome." [GOC:mah]
synonym: "sister chromatid cohesion at centromere" EXACT [GOC:mah]
is_a: GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0070602
name: regulation of centromeric sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome." [GOC:mah]
synonym: "regulation of sister chromatid cohesion at centromere" EXACT [GOC:mah]
is_a: GO:0007063 ! regulation of sister chromatid cohesion
relationship: regulates GO:0070601 ! centromeric sister chromatid cohesion

[Term]
id: GO:0070603
name: SWI/SNF superfamily-type complex
namespace: cellular_component
alt_id: GO:0090544
def: "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]
subset: gocheck_do_not_annotate
synonym: "BAF-type complex" EXACT []
synonym: "SWI-SNF global transcription activator complex" RELATED [CORUM:224]
synonym: "SWI-SNF-type complex" EXACT [GOC:mah]
synonym: "SWI/SNF-type complex" RELATED [GOC:krc]
synonym: "SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex" RELATED [GOC:krc]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1904949 ! ATPase complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0070605
name: regulation of (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0032948 ! regulation of alpha-glucan metabolic process
relationship: regulates GO:0070595 ! (1->3)-alpha-glucan metabolic process

[Term]
id: GO:0070606
name: regulation of (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan formation" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0032949 ! regulation of alpha-glucan biosynthetic process
is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070596 ! (1->3)-alpha-glucan biosynthetic process

[Term]
id: GO:0070607
name: regulation of cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process

[Term]
id: GO:0070608
name: regulation of cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070606 ! regulation of (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process

[Term]
id: GO:0070609
name: regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "regulation of ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process

[Term]
id: GO:0070610
name: regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah]
synonym: "regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
is_a: GO:0070608 ! regulation of cell wall (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070609 ! regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070600 ! fungal-type cell wall (1->3)-alpha-glucan biosynthetic process

[Term]
id: GO:0070611
name: histone H3R2 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to the arginine residue at position 2 of histone H3." [GOC:mah, PMID:17898714]
synonym: "histone H3R2 arginine methyltransferase activity" EXACT []
synonym: "histone methylase activity (H3-R2 specific)" EXACT [GOC:mah]
synonym: "histone methyltransferase activity (H3-R2 specific)" EXACT []
synonym: "histone-arginine N-methyltransferase activity (H3-R2 specific)" EXACT [GOC:mah]
synonym: "histone-H3R2 methyltransferase activity" EXACT []
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0070612
name: histone H2AR3 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H2A." [GOC:mah, PMID:17898714, PMID:23451136]
synonym: "histone H2AR3 arginine methyltransferase activity" EXACT [GOC:mah]
synonym: "histone methylase activity (H2A-R3 specific)" EXACT [GOC:mah]
synonym: "histone methyltransferase activity (H2A-R3 specific)" EXACT []
synonym: "histone-arginine N-methyltransferase activity (H2A-R3 specific)" EXACT [GOC:mah]
synonym: "histone-H2AR3 methyltransferase activity" EXACT []
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0140940 ! histone H2A methyltransferase activity

[Term]
id: GO:0070613
name: regulation of protein processing
namespace: biological_process
alt_id: GO:0010953
def: "Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah]
synonym: "regulation of protein maturation by peptide bond cleavage" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:1903317 ! regulation of protein maturation
relationship: regulates GO:0016485 ! protein processing

[Term]
id: GO:0070614
name: tungstate ion transport
namespace: biological_process
def: "The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten." [GOC:dh]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0070616
name: regulation of thiamine diphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah]
synonym: "regulation of thiamin diphosphate biosynthetic process" EXACT []
synonym: "regulation of thiamine diphosphate anabolism" EXACT [GOC:mah]
synonym: "regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah]
synonym: "regulation of thiamine diphosphate formation" EXACT [GOC:mah]
synonym: "regulation of thiamine diphosphate synthesis" EXACT [GOC:mah]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0009229 ! thiamine diphosphate biosynthetic process

[Term]
id: GO:0070617
name: negative regulation of thiamine diphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah]
synonym: "down regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of thiamine diphosphate biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of thiamin diphosphate biosynthetic process" EXACT []
synonym: "negative regulation of thiamine diphosphate anabolism" EXACT [GOC:mah]
synonym: "negative regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of thiamine diphosphate formation" EXACT [GOC:mah]
synonym: "negative regulation of thiamine diphosphate synthesis" EXACT [GOC:mah]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0070616 ! regulation of thiamine diphosphate biosynthetic process
relationship: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process

[Term]
id: GO:0070618
name: Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
synonym: "Grb2-mSos1 complex" NARROW [CORUM:2545]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070619
name: Shc-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7970708, PMID:8940013]
synonym: "Shc-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2553]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070620
name: EGFR-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
synonym: "Egfr-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2548]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070621
name: EGFR-Shc-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070622
name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
namespace: cellular_component
def: "A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits." [GOC:mah, PMID:8940155]
synonym: "N-acetylglucosamine-1-phosphotransferase complex" RELATED [CORUM:406]
synonym: "UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex" EXACT [PMID:8940155]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0070623
name: regulation of thiamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah]
synonym: "regulation of thiamin biosynthetic process" EXACT []
synonym: "regulation of thiamine anabolism" EXACT [GOC:mah]
synonym: "regulation of thiamine biosynthesis" EXACT [GOC:mah]
synonym: "regulation of thiamine formation" EXACT [GOC:mah]
synonym: "regulation of thiamine synthesis" EXACT [GOC:mah]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0009228 ! thiamine biosynthetic process

[Term]
id: GO:0070624
name: negative regulation of thiamine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah]
synonym: "down regulation of thiamine biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of thiamine biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of thiamine biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of thiamine biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of thiamin biosynthetic process" EXACT []
synonym: "negative regulation of thiamine anabolism" EXACT [GOC:mah]
synonym: "negative regulation of thiamine biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of thiamine formation" EXACT [GOC:mah]
synonym: "negative regulation of thiamine synthesis" EXACT [GOC:mah]
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0070623 ! regulation of thiamine biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0009228 ! thiamine biosynthetic process

[Term]
id: GO:0070625
name: zymogen granule exocytosis
namespace: biological_process
def: "The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions." [GOC:BHF, GOC:vk, PMID:17442889]
is_a: GO:0017156 ! calcium-ion regulated exocytosis

[Term]
id: GO:0070626
name: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [RHEA:23920]
synonym: "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity" RELATED []
synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah]
synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah]
synonym: "SAICAR-lyase (fumarate forming) activity" RELATED []
synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah]
xref: KEGG_REACTION:R04559
xref: MetaCyc:AICARSYN-RXN
xref: Reactome:R-HSA-73800 "SAICAR => AICAR + Fumarate"
xref: Reactome:R-HSA-73828 "adenylosuccinate => adenosine 5'-monophosphate + fumarate"
xref: RHEA:23920
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0070628
name: proteasome binding
namespace: molecular_function
def: "Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]
subset: goslim_chembl
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0070629
name: (1->4)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "(1->4)-alpha-D-glucan metabolism" EXACT [GOC:mah]
synonym: "1,4-alpha-D-glucan metabolism" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan metabolic process" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0070630
name: (1->4)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "(1->4)-alpha-D-glucan anabolism" EXACT [GOC:mah]
synonym: "(1->4)-alpha-D-glucan biosynthesis" EXACT [GOC:mah]
synonym: "(1->4)-alpha-D-glucan formation" EXACT [GOC:mah]
synonym: "(1->4)-alpha-D-glucan synthesis" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan formation" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan anabolism" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan biosynthesis" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan formation" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0070629 ! (1->4)-alpha-glucan metabolic process

[Term]
id: GO:0070631
name: spindle pole body localization
namespace: biological_process
alt_id: GO:0071790
alt_id: GO:1990944
def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah]
synonym: "maintenance of spindle pole body localization" NARROW []
synonym: "spindle pole body localisation" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization
is_a: GO:0061842 ! microtubule organizing center localization

[Term]
id: GO:0070633
name: transepithelial transport
namespace: biological_process
def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363]
is_a: GO:0006810 ! transport

[Term]
id: GO:0070634
name: transepithelial ammonium transport
namespace: biological_process
def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf]
is_a: GO:0070633 ! transepithelial transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0070635
name: nicotinamide riboside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose." [MetaCyc:RXN-8441, PMID:19001417]
synonym: "N-ribosylnicotinamide hydrolase activity" EXACT [CHEBI:15927]
synonym: "nicotinamide ribonucleoside hydrolase activity" EXACT [CHEBI:15927]
xref: MetaCyc:RXN-8441
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0070636
name: nicotinic acid riboside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose." [GOC:mah, PMID:19001417]
synonym: "D-ribosylnicotinate hydrolase activity" EXACT [GOC:mah]
synonym: "D-ribosylnicotinic acid hydrolase activity" EXACT [CHEBI:27748]
synonym: "nicotinate ribonucleoside hydrolase activity" EXACT [GOC:mah]
synonym: "nicotinate riboside hydrolase activity" EXACT [GOC:mah]
synonym: "nicotinic acid ribonucleoside hydrolase activity" EXACT [GOC:mah]
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0070637
name: pyridine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah]
synonym: "pyridine nucleoside metabolism" EXACT [GOC:mah]
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0070638
name: pyridine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah]
synonym: "pyridine nucleoside breakdown" EXACT [GOC:mah]
synonym: "pyridine nucleoside catabolism" EXACT [GOC:mah]
synonym: "pyridine nucleoside degradation" EXACT [GOC:mah]
is_a: GO:0009164 ! nucleoside catabolic process
is_a: GO:0070637 ! pyridine nucleoside metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0070639
name: vitamin D2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol." [GOC:BHF, GOC:mah]
synonym: "calciferol metabolic process" EXACT [CHEBI:28934]
synonym: "ergocalciferol metabolic process" EXACT [CHEBI:28934]
synonym: "vitamin D2 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process

[Term]
id: GO:0070640
name: vitamin D3 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol." [GOC:BHF, GOC:mah]
synonym: "calciol metabolic process" EXACT [CHEBI:28940]
synonym: "cholecalciferol metabolic process" EXACT [CHEBI:28940]
synonym: "vitamin D3 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0070641
name: vitamin D4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol." [GOC:BHF, GOC:mah]
synonym: "vitamin D4 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process

[Term]
id: GO:0070642
name: vitamin D5 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol." [GOC:BHF, GOC:mah, PubChem_Compound:9547700]
synonym: "vitamin D5 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process

[Term]
id: GO:0070643
name: obsolete vitamin D 25-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydroxylation of C-25 of any form of vitamin D." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it was an unnecessary grouping term.
synonym: "calciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "cholecalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "ergocalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "vitamin D2 25-hydroxylase activity" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0030343

[Term]
id: GO:0070644
name: vitamin D response element binding
namespace: molecular_function
def: "Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:vk, PMID:17426122]
synonym: "VDRE binding" EXACT [GOC:vk, PMID:17426122]
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0070645
name: Ubisch body
namespace: cellular_component
def: "A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development." [GOC:ecd, GOC:mah, PMID:14612572, PMID:16524248]
synonym: "orbicule" EXACT [PMID:14612572]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0070646
name: protein modification by small protein removal
namespace: biological_process
def: "A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah]
is_a: GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:0070647
name: protein modification by small protein conjugation or removal
namespace: biological_process
def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah]
subset: goslim_drosophila
subset: goslim_pombe
subset: goslim_yeast
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0070648
name: formin-nucleated actin cable
namespace: cellular_component
def: "An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth." [PMID:14671023, PMID:16959963]
is_a: GO:0097518 ! parallel actin filament bundle

[Term]
id: GO:0070649
name: formin-nucleated actin cable assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:mah, PMID:14671023, PMID:16959963]
synonym: "formin-nucleated actin cable formation" EXACT [GOC:mah]
is_a: GO:0030046 ! parallel actin filament bundle assembly
is_a: GO:0110009 ! formin-nucleated actin cable organization

[Term]
id: GO:0070650
name: actin filament bundle distribution
namespace: biological_process
def: "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell." [GOC:mah]
is_a: GO:0061572 ! actin filament bundle organization

[Term]
id: GO:0070651
name: nonfunctional rRNA decay
namespace: biological_process
def: "An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system." [GOC:mah, GOC:rn, PMID:17188037, PMID:19390089]
synonym: "NRD" RELATED [GOC:rn]
is_a: GO:0016075 ! rRNA catabolic process

[Term]
id: GO:0070652
name: HAUS complex
namespace: cellular_component
def: "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]
synonym: "HAUS augmin complex" EXACT [GOC:mm2]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0070653
name: high-density lipoprotein particle receptor binding
namespace: molecular_function
def: "Binding to a high-density lipoprotein receptor." [GOC:BHF, GOC:mah]
synonym: "HDL receptor binding" EXACT [GOC:mah]
synonym: "high-density lipoprotein receptor binding" EXACT [GOC:dph]
is_a: GO:0070325 ! lipoprotein particle receptor binding

[Term]
id: GO:0070654
name: sensory epithelium regeneration
namespace: biological_process
def: "The regrowth of a sensory epithelium following its loss or destruction." [GOC:dsf, PMID:19381250]
is_a: GO:1990399 ! epithelium regeneration

[Term]
id: GO:0070655
name: mechanosensory epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed mechanosensory epithelia." [GOC:dsf, PMID:19381250]
is_a: GO:0070654 ! sensory epithelium regeneration

[Term]
id: GO:0070656
name: mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
namespace: biological_process
def: "Differentiation of new mechanoreceptors to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0042490 ! mechanoreceptor differentiation
relationship: part_of GO:0070655 ! mechanosensory epithelium regeneration

[Term]
id: GO:0070657
name: neuromast regeneration
namespace: biological_process
def: "The regrowth of a neuromast following its loss or destruction." [GOC:dsf, PMID:19381250]
is_a: GO:0070655 ! mechanosensory epithelium regeneration

[Term]
id: GO:0070658
name: neuromast hair cell differentiation involved in neuromast regeneration
namespace: biological_process
def: "Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0048886 ! neuromast hair cell differentiation
is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
relationship: part_of GO:0070657 ! neuromast regeneration

[Term]
id: GO:0070659
name: inner ear sensory epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed inner ear sensory epithelia." [GOC:dsf, PMID:19381250]
is_a: GO:0070655 ! mechanosensory epithelium regeneration

[Term]
id: GO:0070660
name: inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration
namespace: biological_process
def: "Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0060113 ! inner ear receptor cell differentiation
is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
relationship: part_of GO:0070659 ! inner ear sensory epithelium regeneration

[Term]
id: GO:0070661
name: leukocyte proliferation
namespace: biological_process
def: "The expansion of a leukocyte population by cell division." [GOC:add]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0070662
name: mast cell proliferation
namespace: biological_process
def: "The expansion of a mast cell population by cell division." [GOC:add]
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070663
name: regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070664
name: negative regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: negatively_regulates GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070665
name: positive regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "activation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: positively_regulates GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070666
name: regulation of mast cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: regulates GO:0070662 ! mast cell proliferation

[Term]
id: GO:0070667
name: negative regulation of mast cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of mast cell proliferation" NARROW [GOC:mah]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0070666 ! regulation of mast cell proliferation
relationship: negatively_regulates GO:0070662 ! mast cell proliferation

[Term]
id: GO:0070668
name: positive regulation of mast cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
synonym: "activation of mast cell proliferation" NARROW [GOC:mah]
synonym: "stimulation of mast cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of mast cell proliferation" EXACT [GOC:mah]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0070666 ! regulation of mast cell proliferation
relationship: positively_regulates GO:0070662 ! mast cell proliferation

[Term]
id: GO:0070669
name: response to interleukin-2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah]
synonym: "response to IL-2" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070670
name: response to interleukin-4
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]
synonym: "response to IL-4" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070671
name: response to interleukin-12
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah]
synonym: "response to IL-12" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070672
name: response to interleukin-15
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah]
synonym: "response to IL-15" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070673
name: response to interleukin-18
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah]
synonym: "response to IL-18" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070674
name: hypoxanthine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+." [GOC:mah, GOC:pde]
synonym: "hypoxanthine oxidoreductase activity" BROAD [EC:1.17.1.4]
synonym: "hypoxanthine-NAD oxidoreductase activity" RELATED [EC:1.17.1.4]
synonym: "hypoxanthine/NAD(+) oxidoreductase activity" RELATED [EC:1.17.1.4]
synonym: "hypoxanthine/NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4]
synonym: "hypoxanthine:NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4]
synonym: "NAD-hypoxanthine dehydrogenase activity" RELATED [EC:1.17.1.4]
xref: Reactome:R-HSA-9727347 "XDH dehydrogenates hypoxanthine to form xanthine"
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0070675
name: hypoxanthine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2." [GOC:mah, GOC:pde]
synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2]
synonym: "hypoxanthine:O2 oxidoreductase activity" RELATED [EC:1.17.3.2]
synonym: "hypoxanthine:oxygen oxidoreductase activity" RELATED [EC:1.17.3.2]
synonym: "schardinger enzyme" RELATED [EC:1.17.3.2]
synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2]
xref: Reactome:R-HSA-74247 "XDH oxidizes hypoxanthine to form xanthine"
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0070676
name: intralumenal vesicle formation
namespace: biological_process
def: "The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome." [GOC:jp, PMID:19234443]
synonym: "endosome membrane budding" EXACT [GOC:jp, GOC:mah]
is_a: GO:0006900 ! vesicle budding from membrane
is_a: GO:0007032 ! endosome organization

[Term]
id: GO:0070677
name: rRNA (cytosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine." [GOC:mah, PMID:19400805]
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity
is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity

[Term]
id: GO:0070678
name: preprotein binding
namespace: molecular_function
def: "Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing." [GOC:imk, GOC:mah, PMID:12914940]
synonym: "unprocessed protein binding" EXACT [GOC:imk]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070679
name: inositol 1,4,5 trisphosphate binding
namespace: molecular_function
def: "Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]
synonym: "InsP3 binding" EXACT [GOC:mah]
synonym: "IP3 binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0070680
name: asparaginyl-tRNAAsn biosynthesis via transamidation
namespace: biological_process
def: "A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase." [GOC:mah, MetaCyc:PWY490-4]
xref: MetaCyc:PWY490-4
is_a: GO:0043039 ! tRNA aminoacylation

[Term]
id: GO:0070681
name: glutaminyl-tRNAGln biosynthesis via transamidation
namespace: biological_process
def: "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]
xref: MetaCyc:PWY-5921
is_a: GO:0043039 ! tRNA aminoacylation

[Term]
id: GO:0070682
name: proteasome regulatory particle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex." [GOC:mah, GOC:rb, PMID:19412159]
synonym: "proteasome regulatory complex assembly" EXACT [GOC:mah]
is_a: GO:0043248 ! proteasome assembly

[Term]
id: GO:0070684
name: seminal clot liquefaction
namespace: biological_process
def: "The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa." [GOC:mah, PMID:18482984]
synonym: "semen liquefaction" EXACT [PMID:18482984]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0070685
name: macropinocytic cup
namespace: cellular_component
def: "A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin." [PMID:12538772, PMID:16968738, PMID:9044041]
synonym: "crown" EXACT [GOC:pf, PMID:9044041]
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0070686
name: macropinocytic cup membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a macropinocytic cup." [GOC:mah]
synonym: "crown membrane" EXACT [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0070685 ! macropinocytic cup

[Term]
id: GO:0070687
name: macropinocytic cup cytoskeleton
namespace: cellular_component
def: "The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup." [GOC:mah]
synonym: "crown cytoskeleton" EXACT [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030864 ! cortical actin cytoskeleton
relationship: part_of GO:0070685 ! macropinocytic cup

[Term]
id: GO:0070688
name: obsolete MLL5-L complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively." [GOC:mah, PMID:19377461]
comment: This term was made obsolete because there is no evidence for the existence of this complex.
is_obsolete: true

[Term]
id: GO:0070689
name: L-threonine catabolic process to propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate." [GOC:bf, GOC:mah, MetaCyc:PWY-5437]
synonym: "L-threonine breakdown to propionate" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to propionate" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to propionate" EXACT [GOC:bf, GOC:mah]
synonym: "threonine catabolic process to propionate" BROAD [GOC:bf]
xref: MetaCyc:PWY-5437
is_a: GO:0006567 ! threonine catabolic process
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0070690
name: L-threonine catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA." [GOC:bf, GOC:mah, MetaCyc:PWY-5436]
synonym: "L-threonine breakdown to acetyl-CoA" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to acetyl-CoA" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to acetyl-CoA" EXACT [GOC:bf, GOC:mah]
synonym: "threonine catabolic process to acetyl-CoA" BROAD [GOC:bf]
xref: MetaCyc:PWY-5436
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0006567 ! threonine catabolic process
is_a: GO:0043605 ! amide catabolic process

[Term]
id: GO:0070691
name: P-TEFb complex
namespace: cellular_component
def: "A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T." [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067, Wikipedia:P-TEFb]
synonym: "Bur1/Bur2 complex" NARROW [PMID:16721054, PMID:19328067]
synonym: "cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex" NARROW [GOC:vw]
synonym: "cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex" NARROW [GOC:bhm]
synonym: "dimeric positive transcription elongation factor complex b" RELATED []
synonym: "Sgv1/Bur2 complex" NARROW [GOC:mah]
is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex

[Term]
id: GO:0070692
name: CTDK-1 complex
namespace: cellular_component
def: "A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638)." [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067]
synonym: "C-terminal domain kinase I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067]
synonym: "CTDK-I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067]
synonym: "Ctk complex" EXACT [PMID:16721054]
synonym: "trimeric positive transcription elongation factor complex b" RELATED []
is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex

[Term]
id: GO:0070693
name: P-TEFb-cap methyltransferase complex
namespace: cellular_component
def: "A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase." [PMID:17332744, PMID:19328067]
synonym: "Cdk9-Pcm1 complex" NARROW [GOC:vw]
synonym: "P-TEFb-Pcm1 complex" NARROW [GOC:vw]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070694
name: 5-hydroxymethyl-dUMP N-hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil." [PMID:17234634, RHEA:77099]
synonym: "deoxynucleoside 5'-monophosphate N-glycosidase activity" BROAD []
xref: Reactome:R-HSA-8953339 "DNPH1 hydrolyses dGMP"
xref: RHEA:77099
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0070695
name: FHF complex
namespace: cellular_component
def: "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex)." [GOC:ab, GOC:mah, PMID:18799622]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0070696
name: transmembrane receptor protein serine/threonine kinase binding
namespace: molecular_function
def: "Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity." [GOC:BHF, GOC:mah]
is_a: GO:0033612 ! receptor serine/threonine kinase binding

[Term]
id: GO:0070697
name: activin receptor binding
namespace: molecular_function
def: "Binding to an activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding

[Term]
id: GO:0070698
name: type I activin receptor binding
namespace: molecular_function
def: "Binding to a type I activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070697 ! activin receptor binding

[Term]
id: GO:0070699
name: type II activin receptor binding
namespace: molecular_function
def: "Binding to a type II activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070697 ! activin receptor binding

[Term]
id: GO:0070700
name: BMP receptor binding
namespace: molecular_function
def: "Binding to a BMP receptor." [GOC:BHF, GOC:vk]
synonym: "bone morphogenetic protein receptor binding" EXACT [GOC:mah]
is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding

[Term]
id: GO:0070701
name: mucus layer
namespace: cellular_component
def: "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:krc, GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394, Wikipedia:Mucin]
synonym: "extracellular proteinaceous gel" BROAD []
synonym: "mucous" EXACT []
synonym: "mucous layer" EXACT []
synonym: "mucus" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0070702
name: inner mucus layer
namespace: cellular_component
def: "The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]
is_a: GO:0070701 ! mucus layer

[Term]
id: GO:0070703
name: outer mucus layer
namespace: cellular_component
def: "The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]
is_a: GO:0070701 ! mucus layer

[Term]
id: GO:0070704
name: sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of a double bond into a sterol molecule." [GOC:mah, GOC:vw]
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0070705
name: RNA nucleotide insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of one or more nucleotides." [GOC:cb, GOC:mah]
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0070706
name: RNA nucleotide deletion
namespace: biological_process
def: "The modification of an RNA molecule by removal of a single nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA nucleotide excision" EXACT [GOC:cb, GOC:mah]
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0070707
name: RNA dinucleotide insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a dinucleotide." [GOC:cb, GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0070708
name: RNA cytidine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a cytidine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA C insertion" EXACT [GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0070709
name: RNA guanosine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a guanosine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA G insertion" EXACT [GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0070710
name: RNA uridine deletion
namespace: biological_process
def: "The modification of an RNA molecule by removal of a uridine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA U deletion" EXACT [GOC:mah]
synonym: "RNA uridine excision" EXACT [GOC:cb, GOC:mah]
is_a: GO:0070706 ! RNA nucleotide deletion

[Term]
id: GO:0070711
name: RNA adenosine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA AU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070712
name: RNA cytidine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA CU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070713
name: RNA guanosine-cytidine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA GC insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070714
name: RNA guanosine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA GU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070715
name: sodium-dependent organic cation transport
namespace: biological_process
def: "The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0015695 ! organic cation transport

[Term]
id: GO:0070716
name: mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
namespace: biological_process
def: "A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication." [GOC:BHF, GOC:mah]
synonym: "mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006298 ! mismatch repair
relationship: part_of GO:0045005 ! DNA-templated DNA replication maintenance of fidelity

[Term]
id: GO:0070717
name: poly-purine tract binding
namespace: molecular_function
def: "Binding to a stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah]
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0070718
name: alphaPDGFR-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "PDGFRA-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3183]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070719
name: alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated" NARROW [CORUM:2551]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070720
name: Grb2-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "GRB2-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3186]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070721
name: ISGF3 complex
namespace: cellular_component
def: "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein." [GOC:mah, PMID:8943351]
synonym: "interferon-stimulated gene factor 3 transcription complex" EXACT [CORUM:60]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0070722
name: Tle3-Aes complex
namespace: cellular_component
def: "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product." [GOC:mah, PMID:8955148]
synonym: "Grg3b-Grg5 complex" EXACT [CORUM:3130, PMID:8955148]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070723
name: response to cholesterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0036314 ! response to sterol
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0070724
name: BMP receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits." [GOC:mah, GOC:mh, PMID:19377468]
synonym: "bone morphogenetic protein receptor complex" EXACT [GOC:mah]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0070725
name: Yb body
namespace: cellular_component
def: "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453, PMID:28595904, PMID:31267711]
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0070726
name: cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0071555 ! cell wall organization
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0070727
name: cellular macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
synonym: "cellular macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0070728
name: L-leucine binding
namespace: molecular_function
def: "Binding to L-leucine, 2-amino-4-methylpentanoic acid." [GOC:BHF, GOC:mah]
synonym: "Leu binding" BROAD [GOC:mah]
synonym: "leucine binding" BROAD []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0070729
name: cyclic nucleotide transport
namespace: biological_process
def: "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell." [GOC:mah, ISBN:0198506732]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0070730
name: cAMP transport
namespace: biological_process
def: "The directed movement of cyclic AMP (cAMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732]
synonym: "cyclic AMP transport" EXACT [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0070729 ! cyclic nucleotide transport

[Term]
id: GO:0070731
name: cGMP transport
namespace: biological_process
def: "The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732]
synonym: "cyclic GMP transport" EXACT [GOC:mah]
is_a: GO:0001408 ! guanine nucleotide transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0070729 ! cyclic nucleotide transport

[Term]
id: GO:0070732
name: spindle envelope
namespace: cellular_component
def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]
subset: goslim_candida
is_a: GO:0031967 ! organelle envelope

[Term]
id: GO:0070733
name: AMPylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins." [GOC:mah, PMID:19039103, PMID:19362538, PMID:33947243]
synonym: "adenosine monophosphate-protein transferase activity" EXACT [GOC:mah]
synonym: "AMPylator" RELATED [GOC:mah]
synonym: "protein adenylyltransferase activity" RELATED []
xref: EC:2.7.7.108
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0070734
name: obsolete histone H3-K27 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone." [GOC:mah, GOC:pr]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K27 methylation" EXACT [GOC:mah]
synonym: "histone H3K27me" EXACT [GOC:mah]
synonym: "histone lysine H3 K27 methylation" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070735
name: protein-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate." [RHEA:67180]
synonym: "protein glycylase activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-8867370 "TTLL3, TTLL8, TTLL10 polyglycylate tubulin"
xref: RHEA:67180
is_a: GO:0016881 ! acid-amino acid ligase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0070736
name: protein-glycine ligase activity, initiating
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity, initiating" EXACT [GOC:mah]
is_a: GO:0070735 ! protein-glycine ligase activity

[Term]
id: GO:0070737
name: protein-glycine ligase activity, elongating
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity, elongating" EXACT [GOC:mah]
is_a: GO:0070735 ! protein-glycine ligase activity

[Term]
id: GO:0070738
name: tubulin-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin." [GOC:mah, PMID:19524510]
synonym: "tubulin glycylase activity" EXACT [GOC:mah]
is_a: GO:0070735 ! protein-glycine ligase activity

[Term]
id: GO:0070739
name: protein-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glutamylase activity" EXACT [GOC:mah]
synonym: "protein-glutamate ligase activity" EXACT [GOC:mah]
is_a: GO:0016881 ! acid-amino acid ligase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0070740
name: tubulin-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]
synonym: "tubulin glutamylase activity" EXACT [GOC:mah]
synonym: "tubulin-glutamate ligase activity" EXACT [GOC:mah]
xref: EC:6.3.2.61
xref: Reactome:R-HSA-8865774 "TTLLs polyglutamylate tubulin"
xref: Reactome:R-HSA-8955869 "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin"
is_a: GO:0070739 ! protein-glutamic acid ligase activity

[Term]
id: GO:0070741
name: response to interleukin-6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]
synonym: "response to IL-6" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070742
name: C2H2 zinc finger domain binding
namespace: molecular_function
def: "Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion." [GOC:BHF, GOC:mah, Pfam:PF00096]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070743
name: interleukin-23 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space." [GOC:add, PMID:11114383, PMID:15999093]
comment: Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.
synonym: "IL-23 complex" EXACT [GOC:add]
synonym: "IL12B" NARROW [GOC:add]
synonym: "IL23A" NARROW [GOC:add]
synonym: "p19" NARROW [GOC:add]
synonym: "p40" NARROW [GOC:add]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070744
name: interleukin-27 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:15999093, PMID:19161428]
comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-27 complex" EXACT [GOC:add]
synonym: "IL27" NARROW [GOC:add]
synonym: "p28" NARROW [GOC:add]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070745
name: interleukin-35 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:19161428, PMID:19161429]
comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-35 complex" EXACT [GOC:add]
synonym: "IL12A" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070746
name: interleukin-35 binding
namespace: molecular_function
def: "Binding to interleukin-35." [GOC:add]
synonym: "IL-35 binding" EXACT [GOC:add]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070747
name: interleukin-35 receptor activity
namespace: molecular_function
def: "Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling]
synonym: "IL-35 receptor activity" EXACT [GOC:add]
synonym: "IL-35R" EXACT [GOC:add]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0070748
name: interleukin-35 receptor binding
namespace: molecular_function
def: "Binding to an interleukin-35 receptor." [GOC:add]
synonym: "IL-35" NARROW [GOC:add]
synonym: "interleukin-35 receptor ligand" NARROW [GOC:add]
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0070753
name: interleukin-35 production
namespace: biological_process
alt_id: GO:0070749
alt_id: GO:0072626
def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-35 production" EXACT [GOC:add]
synonym: "interleukin-35 biosynthetic process" NARROW []
synonym: "interleukin-35 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0070754
name: regulation of interleukin-35 production
namespace: biological_process
alt_id: GO:0070750
def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "regulation of IL-35 production" EXACT [GOC:add]
synonym: "regulation of interleukin-35 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0070753 ! interleukin-35 production

[Term]
id: GO:0070755
name: negative regulation of interleukin-35 production
namespace: biological_process
alt_id: GO:0070751
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah]
synonym: "negative regulation of IL-35 production" EXACT [GOC:add]
synonym: "negative regulation of interleukin-35 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0070754 ! regulation of interleukin-35 production
relationship: negatively_regulates GO:0070753 ! interleukin-35 production

[Term]
id: GO:0070756
name: positive regulation of interleukin-35 production
namespace: biological_process
alt_id: GO:0070752
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "activation of interleukin-35 production" NARROW [GOC:mah]
synonym: "positive regulation of IL-35 production" EXACT [GOC:add]
synonym: "positive regulation of interleukin-35 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah]
synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "upregulation of interleukin-35 production" EXACT [GOC:mah]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0070754 ! regulation of interleukin-35 production
relationship: positively_regulates GO:0070753 ! interleukin-35 production

[Term]
id: GO:0070757
name: interleukin-35-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-35 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:mah, GOC:signaling]
synonym: "IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070758
name: regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of an interleukin-35-mediated signaling pathway." [GOC:mah]
synonym: "regulation of IL-35-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070757 ! interleukin-35-mediated signaling pathway

[Term]
id: GO:0070759
name: negative regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of an interleukin-35-mediated signaling pathway." [GOC:mah]
synonym: "negative regulation of IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway
relationship: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway

[Term]
id: GO:0070760
name: positive regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of an interleukin-35-mediated signaling pathway." [GOC:mah]
synonym: "positive regulation of IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway
relationship: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway

[Term]
id: GO:0070761
name: pre-snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]
synonym: "pre-small nucleolar ribonucleoprotein complex" EXACT [GOC:rl]
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0070762
name: nuclear pore transmembrane ring
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "NDC1 complex" EXACT []
synonym: "NDC1 subcomplex" EXACT [PMID:19414609]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0070763
name: Delta1 complex
namespace: cellular_component
def: "A protein complex that consists of homodimer of the Notch ligand Delta1." [PMID:12794186]
synonym: "Delta1 homodimer complex" EXACT [CORUM:3271]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070764
name: gamma-secretase-Delta1 complex
namespace: cellular_component
def: "A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex." [PMID:12794186]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070765
name: gamma-secretase complex
namespace: cellular_component
def: "A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]
synonym: "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW [CORUM:142]
synonym: "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW [CORUM:130, CORUM:2891, CORUM:43, CORUM:45, CORUM:466]
synonym: "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:468]
synonym: "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" NARROW [CORUM:3128]
synonym: "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:467]
synonym: "presenilin complex" EXACT []
synonym: "PS1 complex" NARROW []
synonym: "PS2 complex" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0070766
name: endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof)." [PMID:8973549]
synonym: "SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)" NARROW [CORUM:1876]
synonym: "Stx4-Napa-Vamp3-Nsf-Vamp2 complex" NARROW [CORUM:1876]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070767
name: BRCA1-Rad51 complex
namespace: cellular_component
def: "A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity." [GOC:mah, PMID:9008167]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070768
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof)." [PMID:8999968]
synonym: "Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex" NARROW [CORUM:1873]
synonym: "SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)" NARROW [CORUM:1873]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070769
name: alphaIIb-beta3 integrin-CIB complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin." [PMID:9030514]
synonym: "ITGA2B-ITGB3-CIB1 complex" NARROW [CORUM:2379]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070770
name: alphaIIb-beta3 integrin-CD47-FAK complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK." [PMID:9169439]
synonym: "ITGA2b-ITGB3-CD47-FAK complex" NARROW [CORUM:2896]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070771
name: alphaIIb-beta3 integrin-CD47-Src complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src." [PMID:9169439]
synonym: "ITGA2b-ITGB3-CD47-SRC complex" NARROW [CORUM:2377]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070772
name: PAS complex
namespace: cellular_component
def: "A phosphatidylinositol kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKFYVE in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p." [PMID:18950639, PMID:19037259, PMID:19158662]
synonym: "autophagy-specific phosphatidylinositol 3-kinase complex" RELATED [PMID:24165940]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0070773
name: protein-N-terminal glutamine amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein." [PMID:19560421, RHEA:50680]
synonym: "NtQ-amidase activity" EXACT [PMID:19560421]
xref: EC:3.5.1.122
xref: RHEA:50680
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0070774
name: obsolete phytoceramidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine." [GOC:pde, PMID:11356846]
comment: The reason for obsoletion is that this term represents a specific substrate of GO:0017040 N-acylsphingosine amidohydrolase activity.
xref: Reactome:R-HSA-428262 "ACER3 hydrolyzes phytoceramide"
is_obsolete: true
replaced_by: GO:0017040

[Term]
id: GO:0070775
name: H3 histone acetyltransferase complex
namespace: cellular_component
def: "A multisubunit complex that catalyzes the acetylation of histone H3." [GOC:mah]
synonym: "H3 HAT complex" EXACT [GOC:mah]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0070776
name: MOZ/MORF histone acetyltransferase complex
namespace: cellular_component
def: "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]
is_a: GO:0070775 ! H3 histone acetyltransferase complex

[Term]
id: GO:0070777
name: D-aspartate transmembrane transport
namespace: biological_process
def: "The process in which D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid  is transported across a lipid bilayer, from one side of a membrane to the other, by means of some agent such as a transporter or pore." [GOC:mah, GOC:rph]
is_a: GO:0015810 ! aspartate transmembrane transport
is_a: GO:0042940 ! D-amino acid transport

[Term]
id: GO:0070778
name: L-aspartate transmembrane transport
namespace: biological_process
alt_id: GO:0089712
def: "The directed movement of L-aspartate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]
synonym: "L-aspartate transport" BROAD []
is_a: GO:0015810 ! aspartate transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0070779
name: D-aspartate import across plasma membrane
namespace: biological_process
alt_id: GO:0140016
def: "The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:7914198]
synonym: "D-aspartate import" BROAD []
synonym: "D-aspartate import into cell" EXACT []
synonym: "D-aspartate uptake" EXACT [GOC:mah]
is_a: GO:0070777 ! D-aspartate transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane

[Term]
id: GO:0070780
name: dihydrosphingosine-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate." [GOC:pde, PMID:12815058]
synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:mah]
synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah]
xref: MetaCyc:DHS-PHOSPHATASE-RXN
xref: RHEA:27514
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0070781
name: response to biotin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:sl]
synonym: "response to Bios IIB" EXACT [GOC:sl]
synonym: "response to coenzyme R" EXACT [GOC:sl]
synonym: "response to vitamin B7" EXACT [GOC:sl]
synonym: "response to vitamin H" EXACT [GOC:sl]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0070782
name: phosphatidylserine exposure on apoptotic cell surface
namespace: biological_process
def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity." [GOC:mah, GOC:mtg_apoptosis, GOC:rk, PMID:11536005]
comment: In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure.
synonym: "externalization of phosphatidylserine" EXACT [GOC:rk]
is_a: GO:0017121 ! plasma membrane phospholipid scrambling
relationship: part_of GO:0097194 ! execution phase of apoptosis

[Term]
id: GO:0070783
name: growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc]
subset: goslim_candida
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:0070784
name: regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0070785
name: negative regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
relationship: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0070786
name: positive regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
relationship: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0070787
name: conidiophore development
namespace: biological_process
def: "The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [PMID:9529886]
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0070788
name: conidiophore stalk development
namespace: biological_process
def: "The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [PMID:9529886]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0070787 ! conidiophore development

[Term]
id: GO:0070789
name: metula development
namespace: biological_process
def: "The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [PMID:9529886]
synonym: "development of primary sterigmata" EXACT [PMID:9529886]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070787 ! conidiophore development

[Term]
id: GO:0070790
name: phialide development
namespace: biological_process
def: "The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips." [PMID:9529886]
synonym: "development of secondary sterigmata" EXACT [PMID:9529886]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070787 ! conidiophore development

[Term]
id: GO:0070791
name: cleistothecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [ISBN:0471522295, PMID:17446882]
is_a: GO:0000909 ! sporocarp development involved in sexual reproduction

[Term]
id: GO:0070792
name: Hulle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [PMID:19210625]
synonym: "Huelle cell development" EXACT [GOC:mah]
synonym: "Hulle cell formation" NARROW [PMID:19210625]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070791 ! cleistothecium development

[Term]
id: GO:0070793
name: regulation of conidiophore development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0070787 ! conidiophore development

[Term]
id: GO:0070794
name: negative regulation of conidiophore development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
relationship: negatively_regulates GO:0070787 ! conidiophore development

[Term]
id: GO:0070795
name: positive regulation of conidiophore development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
relationship: positively_regulates GO:0070787 ! conidiophore development

[Term]
id: GO:0070796
name: regulation of cleistothecium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction
relationship: regulates GO:0070791 ! cleistothecium development

[Term]
id: GO:0070797
name: negative regulation of cleistothecium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:0070796 ! regulation of cleistothecium development
is_a: GO:1902059 ! negative regulation of sporocarp development involved in sexual reproduction
relationship: negatively_regulates GO:0070791 ! cleistothecium development

[Term]
id: GO:0070798
name: positive regulation of cleistothecium development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:0070796 ! regulation of cleistothecium development
is_a: GO:1902060 ! positive regulation of sporocarp development involved in sexual reproduction
relationship: positively_regulates GO:0070791 ! cleistothecium development

[Term]
id: GO:0070799
name: regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0070788 ! conidiophore stalk development

[Term]
id: GO:0070800
name: negative regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0070799 ! regulation of conidiophore stalk development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0070788 ! conidiophore stalk development

[Term]
id: GO:0070801
name: positive regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0070795 ! positive regulation of conidiophore development
is_a: GO:0070799 ! regulation of conidiophore stalk development
relationship: positively_regulates GO:0070788 ! conidiophore stalk development

[Term]
id: GO:0070802
name: regulation of metula development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0070793 ! regulation of conidiophore development
relationship: regulates GO:0070789 ! metula development

[Term]
id: GO:0070803
name: negative regulation of metula development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070802 ! regulation of metula development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0070789 ! metula development

[Term]
id: GO:0070804
name: positive regulation of metula development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070802 ! regulation of metula development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0070789 ! metula development

[Term]
id: GO:0070805
name: regulation of phialide development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0070790 ! phialide development

[Term]
id: GO:0070806
name: negative regulation of phialide development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070794 ! negative regulation of conidiophore development
is_a: GO:0070805 ! regulation of phialide development
relationship: negatively_regulates GO:0070790 ! phialide development

[Term]
id: GO:0070807
name: positive regulation of phialide development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070805 ! regulation of phialide development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0070790 ! phialide development

[Term]
id: GO:0070808
name: regulation of Hulle cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0070792 ! Hulle cell development

[Term]
id: GO:0070809
name: negative regulation of Hulle cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070808 ! regulation of Hulle cell development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0070792 ! Hulle cell development

[Term]
id: GO:0070810
name: positive regulation of Hulle cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070808 ! regulation of Hulle cell development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0070792 ! Hulle cell development

[Term]
id: GO:0070811
name: glycerol-2-phosphate transmembrane transport
namespace: biological_process
def: "The process in which glycerol-2-phosphate is transported across a membrane. Glycerol-2-phosphate is a phosphoric monoester of glycerol." [GOC:mah]
synonym: "glycerol-2-phosphate transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0055085 ! transmembrane transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0070813
name: hydrogen sulfide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydrogen sulfide, H2S." [GOC:mah]
synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah]
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0070814
name: hydrogen sulfide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [GOC:mah]
synonym: "hydrogen sulfide anabolism" EXACT [GOC:mah]
synonym: "hydrogen sulfide biosynthesis" EXACT [GOC:mah]
synonym: "hydrogen sulfide formation" EXACT [GOC:mah]
synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah]
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0070813 ! hydrogen sulfide metabolic process

[Term]
id: GO:0070815
name: peptidyl-lysine 5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2." [PMID:19574390]
synonym: "lysine hydroxylase activity" BROAD [GOC:mah]
synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [GOC:mah]
synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [GOC:mah]
synonym: "lysyl hydroxylase activity" BROAD [GOC:mah]
synonym: "peptide-lysine 5-dioxygenase activity" EXACT [GOC:mah]
synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" RELATED [EC:1.14.11.4, GOC:mah]
synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" RELATED [EC:1.14.11.4, GOC:mah]
synonym: "protein lysine hydroxylase activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-9630022 "JMJD6 dimer hydroxylates lysine residues of U2AF2"
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0070816
name: obsolete phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
alt_id: GO:0016245
def: "OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]
comment: This term was obsoleted because it represents a molecular function.
synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah]
synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc]
synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc]
synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc]
is_obsolete: true
consider: GO:0008353

[Term]
id: GO:0070817
name: P-TEFb-cap methyltransferase complex localization
namespace: biological_process
def: "Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of P-TEFb-cap methyltransferase complex localization" EXACT [GOC:MAH]
synonym: "P-TEFb-cap methyltransferase complex localisation" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0070818
name: protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor." [GOC:mah, PMID:19583219]
synonym: "protoporphyrinogen IX oxidase activity" RELATED [EC:1.3.3.4]
synonym: "protoporphyrinogen-IX oxidase activity" RELATED [EC:1.3.3.4]
synonym: "protoporphyrinogenase activity" RELATED [EC:1.3.3.4]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0070819
name: menaquinone-dependent protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone." [GOC:mah, PMID:19583219]
synonym: "protoporphyrinogen-IX:menaquinone oxidoreductase activity" EXACT [GOC:mah]
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
is_a: GO:0070818 ! protoporphyrinogen oxidase activity

[Term]
id: GO:0070820
name: tertiary granule
namespace: cellular_component
def: "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
synonym: "gelatinase granule" EXACT [PMID:23650620]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0070821
name: tertiary granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a tertiary granule." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0070820 ! tertiary granule

[Term]
id: GO:0070822
name: Sin3-type complex
namespace: cellular_component
def: "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0070823
name: HDA1 complex
namespace: cellular_component
def: "A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p." [GOC:dgf, GOC:mah, PMID:11287668, PMID:8663039]
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0070824
name: SHREC complex
namespace: cellular_component
def: "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures." [GOC:mah, PMID:17289569]
synonym: "Snf2/HDAC containing repressor complex" EXACT [PMID:17289569, PMID:27105116]
synonym: "Snf2/Hdac repressive complex" EXACT [PMID:27105116]
is_a: GO:0016581 ! NuRD complex

[Term]
id: GO:0070825
name: chrorion micropyle
namespace: cellular_component
def: "A single cone-shaped specialization that forms an opening in the egg chorion that allows sperm entry into the egg prior to fertilization." [GOC:cvs, GOC:mah, PMID:18649270]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042600 ! egg chorion

[Term]
id: GO:0070826
name: paraferritin complex
namespace: cellular_component
def: "A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme." [GOC:mah, GOC:rph, PMID:11842004, PMID:8639593]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0070827
name: obsolete chromatin maintenance
namespace: biological_process
def: "OBSOLETE. The chromatin organization process that preserves chromatin in a stable functional or structural state." [GOC:mah]
comment: This term was obsoleted because it is redundant with chromatin organization and assembly terms.
is_obsolete: true

[Term]
id: GO:0070828
name: heterochromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah]
synonym: "heterochromatin organisation" EXACT [GOC:mah]
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0070829
name: obsolete heterochromatin maintenance
namespace: biological_process
alt_id: GO:0006344
alt_id: GO:0070870
def: "OBSOLETE. The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah]
comment: This term was obsoleted because it is redundant with heterochromatin organization and assembly terms.
synonym: "heterochromatin maintenance involved in chromatin silencing" RELATED []
synonym: "maintenance of chromatin silencing" RELATED []
synonym: "maintenance of heterochromatic silencing" RELATED []
is_obsolete: true

[Term]
id: GO:0070830
name: bicellular tight junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah]
synonym: "tight junction formation" EXACT [GOC:mah]
is_a: GO:0120192 ! tight junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0070831
name: basement membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]
comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer.
is_a: GO:0071711 ! basement membrane organization
is_a: GO:0085029 ! extracellular matrix assembly

[Term]
id: GO:0070832
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-2]
xref: MetaCyc:PWY4FS-2
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0070833
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-3]
xref: MetaCyc:PWY4FS-3
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0070834
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-4]
xref: MetaCyc:PWY4FS-4
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0070835
name: chromium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chromium (Cr) ions from one side of a membrane to the other." [GOC:mah, GOC:yaf]
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity

[Term]
id: GO:0070836
name: caveola assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858]
synonym: "caveola formation" EXACT [GOC:mah]
synonym: "caveolar biogenesis" RELATED [PMID:12633858]
is_a: GO:0044854 ! plasma membrane raft assembly

[Term]
id: GO:0070837
name: dehydroascorbic acid transport
namespace: biological_process
def: "The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C." [GOC:sl]
synonym: "dehydroascorbate transport" EXACT [GOC:sl]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0070840
name: dynein complex binding
namespace: molecular_function
alt_id: GO:0045502
def: "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]
synonym: "dynein binding" RELATED []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0070841
name: inclusion body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah]
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0070842
name: aggresome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537]
is_a: GO:0070841 ! inclusion body assembly

[Term]
id: GO:0070843
name: misfolded protein transport
namespace: biological_process
def: "The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0070844
name: polyubiquitinated protein transport
namespace: biological_process
def: "The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
synonym: "polyubiquitylated protein transport" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0070845
name: polyubiquitinated misfolded protein transport
namespace: biological_process
def: "The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
synonym: "misfolded polyubiquitinated protein transport" RELATED [GOC:mah]
synonym: "polyubiquitylated misfolded protein transport" EXACT [GOC:mah]
is_a: GO:0070843 ! misfolded protein transport
is_a: GO:0070844 ! polyubiquitinated protein transport

[Term]
id: GO:0070846
name: Hsp90 deacetylation
namespace: biological_process
def: "The modification of an Hsp90 protein by removal of acetyl groups." [GOC:BHF, GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006476 ! protein deacetylation

[Term]
id: GO:0070847
name: core mediator complex
namespace: cellular_component
def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
synonym: "C mediator complex" EXACT [PMID:17870225]
synonym: "S mediator complex" EXACT [PMID:17043218]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0070848
name: response to growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah]
synonym: "response to growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus

[Term]
id: GO:0070849
name: response to epidermal growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah]
synonym: "response to EGF stimulus" EXACT [GOC:mah]
synonym: "response to epidermal growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:0070850
name: TACC/TOG complex
namespace: cellular_component
def: "A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase." [GOC:mah, GOC:vw, PMID:19606211]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0070851
name: growth factor receptor binding
namespace: molecular_function
def: "Binding to a growth factor receptor." [GOC:mah, GOC:vw]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0070852
name: cell body fiber
namespace: cellular_component
def: "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches." [GOC:dos, GOC:mah]
synonym: "cell body fibre" EXACT []
synonym: "primary neurite" RELATED [GOC:dos, GOC:mah]
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0070853
name: myosin VI binding
namespace: molecular_function
def: "Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [GOC:mah, PMID:15473855]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0070854
name: myosin VI heavy chain binding
namespace: molecular_function
def: "Binding to a heavy chain of a myosin VI complex." [GOC:sart]
is_a: GO:0032036 ! myosin heavy chain binding
is_a: GO:0070853 ! myosin VI binding

[Term]
id: GO:0070855
name: myosin VI head/neck binding
namespace: molecular_function
def: "Binding to the head/neck region of a myosin VI heavy chain." [GOC:sart]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0070854 ! myosin VI heavy chain binding

[Term]
id: GO:0070856
name: myosin VI light chain binding
namespace: molecular_function
def: "Binding to a light chain of a myosin VI complex." [GOC:sart]
is_a: GO:0032027 ! myosin light chain binding
is_a: GO:0070853 ! myosin VI binding

[Term]
id: GO:0070857
name: regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "regulation of bile acid formation" EXACT [GOC:mah]
synonym: "regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
relationship: regulates GO:0006699 ! bile acid biosynthetic process

[Term]
id: GO:0070858
name: negative regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of bile acid formation" EXACT [GOC:mah]
synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
is_a: GO:1904252 ! negative regulation of bile acid metabolic process
relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process

[Term]
id: GO:0070859
name: positive regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of bile acid formation" EXACT [GOC:mah]
synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah]
synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
is_a: GO:1904253 ! positive regulation of bile acid metabolic process
relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process

[Term]
id: GO:0070860
name: RNA polymerase I core factor complex
namespace: cellular_component
def: "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872]
comment: Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does.
is_a: GO:0000120 ! RNA polymerase I transcription regulator complex

[Term]
id: GO:0070861
name: regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "regulation of protein export from ER" EXACT [GOC:mah]
is_a: GO:0033157 ! regulation of intracellular protein transport
relationship: regulates GO:0032527 ! protein exit from endoplasmic reticulum

[Term]
id: GO:0070862
name: negative regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "down regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "down-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "downregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "inhibition of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "negative regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "negative regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "negative regulation of protein export from ER" EXACT [GOC:mah]
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
is_a: GO:0090317 ! negative regulation of intracellular protein transport
relationship: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum

[Term]
id: GO:0070863
name: positive regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "activation of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "positive regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "positive regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "positive regulation of protein export from ER" EXACT [GOC:mah]
synonym: "stimulation of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "up regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "up-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "upregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
is_a: GO:0090316 ! positive regulation of intracellular protein transport
relationship: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum

[Term]
id: GO:0070864
name: sperm individualization complex
namespace: cellular_component
def: "A cellular structure that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0070865
name: investment cone
namespace: cellular_component
def: "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716]
synonym: "F-actin cone" EXACT [PMID:15829565]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0070864 ! sperm individualization complex

[Term]
id: GO:0070866
name: sterol-dependent protein binding
namespace: molecular_function
def: "Binding to a protein or protein complex in the presence of sterols." [GOC:ecd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070867
name: mating projection tip membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a mating projection tip." [GOC:mah]
synonym: "mating projection membrane fusion domain" EXACT [PMID:29134248]
synonym: "shmoo tip membrane" NARROW [GOC:mah]
is_a: GO:0031520 ! plasma membrane of cell tip
relationship: part_of GO:0043332 ! mating projection tip

[Term]
id: GO:0070868
name: obsolete heterochromatin organization involved in chromatin silencing
namespace: biological_process
def: "OBSOLETE. Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]
comment: This term was obsoleted because it was not clearly defined, and used incorrectly.
synonym: "heterochromatin organisation involved in chromatin silencing" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070871
name: cell wall organization involved in conjugation with cellular fusion
namespace: biological_process
def: "A process of cell wall organization that contributes to conjugation with cellular fusion." [GOC:mah]
synonym: "cell wall organisation involved in conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0071555 ! cell wall organization
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0070873
name: regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0005977 ! glycogen metabolic process

[Term]
id: GO:0070874
name: negative regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: negatively_regulates GO:0005977 ! glycogen metabolic process

[Term]
id: GO:0070875
name: positive regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: positively_regulates GO:0005977 ! glycogen metabolic process

[Term]
id: GO:0070876
name: SOSS complex
namespace: cellular_component
def: "A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0070877
name: microprocessor complex
namespace: cellular_component
def: "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1903095 ! ribonuclease III complex

[Term]
id: GO:0070878
name: primary miRNA binding
namespace: molecular_function
def: "Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding." [GOC:sl, PMID:15531877, PMID:15574589]
synonym: "pri-miRNA binding" EXACT []
synonym: "primary microRNA binding" EXACT [PMID:15531877, PMID:15574589]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0070879
name: fungal-type cell wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah, GOC:vw]
synonym: "fungal-type cell wall beta-glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034406 ! cell wall beta-glucan metabolic process
is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0070880
name: fungal-type cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah]
synonym: "fungal-type cell wall beta-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process

[Term]
id: GO:0070881
name: regulation of proline transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline transport." [GOC:mah]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0015824 ! proline transport

[Term]
id: GO:0070883
name: pre-miRNA binding
namespace: molecular_function
def: "Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]
synonym: "pre-microRNA binding" EXACT [GOC:pr]
synonym: "precursor microRNA binding" EXACT [PMID:18951094]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0070884
name: regulation of calcineurin-NFAT signaling cascade
namespace: biological_process
alt_id: GO:0051531
alt_id: GO:0051532
def: "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai]
synonym: "NFAT protein import into nucleus" NARROW []
synonym: "regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
synonym: "regulation of NFAT protein import into nucleus" NARROW []
is_a: GO:0106056 ! regulation of calcineurin-mediated signaling
relationship: regulates GO:0033173 ! calcineurin-NFAT signaling cascade

[Term]
id: GO:0070885
name: negative regulation of calcineurin-NFAT signaling cascade
namespace: biological_process
alt_id: GO:0051534
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:mah]
synonym: "down regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "down-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "downregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "inhibition of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
synonym: "inhibition of NFAT protein import into nucleus" NARROW []
synonym: "negative regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "negative regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
synonym: "negative regulation of NFAT protein import into nucleus" NARROW []
synonym: "termination of calcineurin-NFAT signaling cascade" NARROW [GOC:bf]
is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade
is_a: GO:0106057 ! negative regulation of calcineurin-mediated signaling
relationship: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade

[Term]
id: GO:0070886
name: positive regulation of calcineurin-NFAT signaling cascade
namespace: biological_process
alt_id: GO:0051533
def: "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade." [GOC:mah]
synonym: "activation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
synonym: "positive regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "positive regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
synonym: "positive regulation of NFAT protein import into nucleus" NARROW []
synonym: "stimulation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
synonym: "up regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "up-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "upregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade
is_a: GO:0106058 ! positive regulation of calcineurin-mediated signaling
relationship: positively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade

[Term]
id: GO:0070887
name: cellular response to chemical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0070888
name: E-box binding
namespace: molecular_function
def: "Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799]
synonym: "E-box promoter binding" EXACT [GOC:vk]
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0070889
name: platelet alpha granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets." [GOC:rph, PMID:16123220]
synonym: "platelet alpha granule organisation" EXACT [GOC:mah]
synonym: "platelet alpha granule organization and biogenesis" RELATED [GOC:mah]
synonym: "platelet alpha-granule organization" EXACT [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0070891
name: lipoteichoic acid binding
namespace: molecular_function
def: "Binding to lipoteichoic acid." [GOC:add, PMID:14665680]
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0070892
name: lipoteichoic acid immune receptor activity
namespace: molecular_function
def: "Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response." [GOC:add, PMID:14665680]
synonym: "lipoteichoic acid receptor activity" BROAD []
is_a: GO:0038187 ! pattern recognition receptor activity

[Term]
id: GO:0070893
name: obsolete transposon integration
namespace: biological_process
def: "OBSOLETE. Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome." [GOC:jp, PMID:10882723]
comment: This term was obsoleted because it represents a readout.
is_obsolete: true
consider: GO:0006313
consider: GO:0032197

[Term]
id: GO:0070894
name: obsolete regulation of transposon integration
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah]
comment: This term was obsoleted because it represents a readout.
is_obsolete: true
consider: GO:0006313
consider: GO:0032197

[Term]
id: GO:0070895
name: obsolete negative regulation of transposon integration
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah]
comment: This term was obsoleted because it represents a readout.
synonym: "down regulation of transposon integration" EXACT [GOC:mah]
synonym: "down-regulation of transposon integration" EXACT [GOC:mah]
synonym: "downregulation of transposon integration" EXACT [GOC:mah]
synonym: "inhibition of transposon integration" NARROW [GOC:mah]
is_obsolete: true
consider: GO:0006313
consider: GO:0032197

[Term]
id: GO:0070896
name: obsolete positive regulation of transposon integration
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah]
comment: This term was obsoleted because it represents a readout.
synonym: "activation of transposon integration" NARROW [GOC:mah]
synonym: "stimulation of transposon integration" NARROW [GOC:mah]
synonym: "up regulation of transposon integration" EXACT [GOC:mah]
synonym: "up-regulation of transposon integration" EXACT [GOC:mah]
synonym: "upregulation of transposon integration" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006313
consider: GO:0032197

[Term]
id: GO:0070897
name: transcription preinitiation complex assembly
namespace: biological_process
alt_id: GO:0001126
def: "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]
synonym: "bacterial-type RNA polymerase preinitiation complex assembly" NARROW []
synonym: "bacterial-type RNA polymerase transcription PIC formation" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" NARROW []
synonym: "DNA-dependent transcriptional preinitiation complex assembly" EXACT [GOC:txnOH]
synonym: "DNA-templated transcriptional preinitiation complex assembly" EXACT []
synonym: "transcription PIC biosynthesis" BROAD [GOC:mah]
synonym: "transcription PIC formation" BROAD [GOC:mah]
synonym: "transcriptional preinitiation complex formation" BROAD [GOC:mah]
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006352 ! DNA-templated transcription initiation

[Term]
id: GO:0070898
name: RNA polymerase III preinitiation complex assembly
namespace: biological_process
alt_id: GO:0000999
alt_id: GO:0001020
alt_id: GO:0001021
alt_id: GO:0001043
def: "The formation of a large multiprotein-DNA complex that self-assembles on a tRNA gene through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC), (which includes BDP1, BRF1, TBP, TFIIIC in human). The PIC engages RNA polymerase III on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH, PMID:11387215, PMID:12381659]
synonym: "RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly" NARROW []
synonym: "RNA polymerase III transcription PIC biosynthesis" EXACT [GOC:mah]
synonym: "RNA polymerase III transcription PIC formation" EXACT [GOC:mah]
synonym: "RNA polymerase III transcriptional preinitiation complex assembly" EXACT []
synonym: "RNA polymerase III transcriptional preinitiation complex formation" EXACT [GOC:mah]
synonym: "RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly" NARROW []
synonym: "RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly" NARROW []
synonym: "RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly" NARROW []
is_a: GO:0070897 ! transcription preinitiation complex assembly
relationship: part_of GO:0006384 ! transcription initiation at RNA polymerase III promoter

[Term]
id: GO:0070899
name: mitochondrial tRNA wobble uridine modification
namespace: biological_process
def: "The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified." [GOC:mah, GOC:mcc]
is_a: GO:0002098 ! tRNA wobble uridine modification
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070900
name: mitochondrial tRNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically." [GOC:mah, GOC:mcc]
is_a: GO:0006400 ! tRNA modification
is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process
is_a: GO:0090646 ! mitochondrial tRNA processing
is_a: GO:1900864 ! mitochondrial RNA modification

[Term]
id: GO:0070901
name: mitochondrial tRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0030488 ! tRNA methylation
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070902
name: mitochondrial tRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0031119 ! tRNA pseudouridine synthesis
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070903
name: mitochondrial tRNA thio-modification
namespace: biological_process
def: "The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0034227 ! tRNA thio-modification
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070904
name: obsolete transepithelial L-ascorbic acid transport
namespace: biological_process
def: "OBSOLETE. The directed movement of L-ascorbic acid from one side of an epithelium to the other." [GOC:mah, GOC:yaf]
comment: This term was obsoleted because it represents a combination of a process and an anatomical entity.
synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah]
synonym: "transepithelial vitamin C transport" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0015882
consider: GO:0070633

[Term]
id: GO:0070905
name: serine binding
namespace: molecular_function
def: "Binding to 2-amino-3-hydroxypropanoic acid." [GOC:rph]
synonym: "Ser binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0070906
name: aspartate:alanine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)." [GOC:dh]
synonym: "aspartate-alanine antiporter activity" EXACT [GOC:mah]
synonym: "aspartate/alanine antiporter activity" EXACT [GOC:mah]
xref: RHEA:33139
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
is_a: GO:0022858 ! alanine transmembrane transporter activity

[Term]
id: GO:0070907
name: L-histidine:histamine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine(out) + histamine(in) = L-histidine(in) + histamine(out)." [GOC:dh]
synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah]
synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah]
synonym: "histidine:histamine antiporter activity" BROAD []
is_a: GO:0005290 ! L-histidine transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0160173 ! histamine transmembrane transporter activity

[Term]
id: GO:0070908
name: tyrosine:tyramine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh]
synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah]
synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah]
is_a: GO:0005302 ! L-tyrosine transmembrane transporter activity
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0070909
name: glutamate:gamma-aminobutyric acid antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out)." [GOC:dh]
synonym: "glutamate-gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah]
synonym: "glutamate/gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah]
synonym: "glutamate: GABA antiporter activity" EXACT [GOC:dh]
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity

[Term]
id: GO:0070910
name: cell wall macromolecule catabolic process involved in cell wall disassembly
namespace: biological_process
def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall." [GOC:mah]
is_a: GO:0016998 ! cell wall macromolecule catabolic process
relationship: part_of GO:0044277 ! cell wall disassembly

[Term]
id: GO:0070911
name: global genome nucleotide-excision repair
namespace: biological_process
def: "The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome." [PMID:10197977, PMID:18794354]
synonym: "GG-NER" EXACT [PMID:10197977]
synonym: "GGR" EXACT [GOC:vw, PMID:18794354]
synonym: "global genome NER" EXACT [GOC:mah]
synonym: "global genomic nucleotide-excision repair" EXACT [GOC:mah, GOC:vw]
synonym: "global genomic repair" EXACT [GOC:vw, PMID:18794354]
is_a: GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0070912
name: Ddb1-Ckn1 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070913
name: Ddb1-Wdr21 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070914
name: UV-damage excision repair
namespace: biological_process
def: "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]
synonym: "AER" RELATED [GOC:mah, PMID:10704216]
synonym: "alternative excision repair" RELATED [GOC:mah, PMID:10704216]
synonym: "UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:vw]
synonym: "UVDE-dependent excision repair" EXACT [GOC:vw, PMID:9619100]
synonym: "UVER" EXACT [GOC:vw, PMID:9619100]
is_a: GO:0006281 ! DNA repair
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0070915
name: lysophosphatidic acid receptor activity
namespace: molecular_function
def: "Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:15755723]
synonym: "LPA receptor activity" EXACT [PMID:15755723]
is_a: GO:0045125 ! bioactive lipid receptor activity

[Term]
id: GO:0070916
name: inositol phosphoceramide synthase complex
namespace: cellular_component
def: "A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces)." [GOC:mah, PMID:19726565]
synonym: "IPC synthase complex" EXACT [GOC:mah]
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0070917
name: inositol phosphoceramide synthase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of inositol phosphoceramide synthase." [GOC:mah]
comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "IPC synthase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0070918
name: regulatory ncRNA processing
namespace: biological_process
alt_id: GO:0031051
def: "A process leading to the generation of a functional regulatory non-coding RNA." [GOC:mah, PMID:15196465, PMID:19239886]
subset: gocheck_do_not_annotate
synonym: "gene silencing by RNA, production of guide RNA" NARROW [GOC:mah]
synonym: "gene silencing by RNA, production of small RNA" NARROW [GOC:mah]
synonym: "primary sncRNA processing" NARROW []
synonym: "production of small RNA involved in gene silencing by RNA" NARROW []
synonym: "small regulatory ncRNA maturation" NARROW []
synonym: "small regulatory ncRNA processing" NARROW []
synonym: "sncRNA processing" NARROW []
synonym: "sncRNA production" NARROW []
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0031047 ! regulatory ncRNA-mediated gene silencing

[Term]
id: GO:0070920
name: regulation of regulatory ncRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing." [GOC:mah]
synonym: "regulation of gene silencing by RNA, production of guide RNA" EXACT [GOC:mah]
synonym: "regulation of gene silencing by RNA, production of small RNA" EXACT [GOC:mah]
synonym: "regulation of production of small RNA involved in gene silencing by RNA" NARROW []
is_a: GO:0060966 ! regulation of gene silencing by regulatory ncRNA
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0070918 ! regulatory ncRNA processing

[Term]
id: GO:0070921
name: regulation of siRNA processing
namespace: biological_process
alt_id: GO:0090065
def: "Any process that modulates the frequency, rate or extent of siRNA processing." [GOC:mah]
synonym: "regulation of chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah]
synonym: "regulation of production of siRNA involved in chromatin silencing by small RNA" EXACT []
synonym: "regulation of production of siRNA involved in gene silencing by small RNA" RELATED []
synonym: "regulation of production of siRNA involved in post-transcriptional gene silencing by RNA" RELATED []
synonym: "regulation of production of siRNA involved in PTGS" RELATED []
synonym: "regulation of production of siRNA involved in RNA interference" EXACT []
synonym: "regulation of RNA interference, production of siRNA" EXACT [GOC:mah]
synonym: "regulation of siRNA production" RELATED []
is_a: GO:0070920 ! regulation of regulatory ncRNA processing
relationship: regulates GO:0030422 ! siRNA processing

[Term]
id: GO:0070922
name: RISC complex assembly
namespace: biological_process
alt_id: GO:0035087
alt_id: GO:0035280
alt_id: GO:0070923
def: "The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing complement complex that mediates gene silencing by small RNA." [PMID:14512631, PMID:14744438, PMID:19239886, PMID:22233755, PMID:27184117]
synonym: "gene silencing by RNA, small RNA loading onto RISC" RELATED [GOC:mah]
synonym: "miRISC assembly" BROAD []
synonym: "miRNA loading onto RISC" NARROW []
synonym: "RISC assembly" RELATED [GOC:mah]
synonym: "siRNA loading onto RISC involved in gene silencing by small RNA" NARROW []
synonym: "siRNA loading onto RISC involved in RNA interference" NARROW []
synonym: "small RNA loading onto RISC" RELATED []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0031047 ! regulatory ncRNA-mediated gene silencing

[Term]
id: GO:0070925
name: organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0070926
name: regulation of ATP:ADP antiporter activity
namespace: biological_process
def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0022898 ! regulation of transmembrane transporter activity
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:1903959 ! regulation of monoatomic anion transmembrane transport

[Term]
id: GO:0070927
name: obsolete negative regulation of ATP:ADP antiporter activity
namespace: biological_process
def: "OBSOLETE. Any process that stops or reduces the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "down-regulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "downregulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "inhibition of ATP:ADP antiporter activity" NARROW [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070928
name: obsolete regulation of mRNA stability, ncRNA-mediated
namespace: biological_process
def: "OBSOLETE. Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jh2]
comment: This term was obsoleted because it represents the same process as regulatory ncRNA-mediated post-transcriptional gene silencing ; GO:0035194.
synonym: "ncRNA-mediated regulation of mRNA stability" EXACT [GOC:mah]
synonym: "regulation of mRNA stability, non-coding RNA-mediated" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0035194

[Term]
id: GO:0070929
name: trans-translation
namespace: biological_process
def: "A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes." [GOC:jh2, GOC:mah]
is_a: GO:0006414 ! translational elongation

[Term]
id: GO:0070930
name: trans-translation-dependent protein tagging
namespace: biological_process
def: "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation." [GOC:jh2, GOC:jsg, GOC:mah]
comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus.
subset: gocheck_do_not_annotate
synonym: "co-translational protein tagging" EXACT [GOC:jh2, GOC:jsg]
synonym: "cotranslational protein tagging" EXACT [GOC:mah]
synonym: "protein modification by trans-translation" EXACT [GOC:mah]
is_a: GO:0043686 ! co-translational protein modification

[Term]
id: GO:0070931
name: Golgi-associated vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a Golgi-associated vesicle." [GOC:mah]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0070932
name: obsolete histone H3 deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0070933
name: obsolete histone H4 deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0070934
name: CRD-mediated mRNA stabilization
namespace: biological_process
def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303]
synonym: "coding region determinant-mediated mRNA stabilization" EXACT [GOC:mah]
is_a: GO:0048255 ! mRNA stabilization

[Term]
id: GO:0070935
name: 3'-UTR-mediated mRNA stabilization
namespace: biological_process
def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]
synonym: "3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:mah]
is_a: GO:0048255 ! mRNA stabilization

[Term]
id: GO:0070936
name: protein K48-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]
synonym: "protein K48-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0070937
name: CRD-mediated mRNA stability complex
namespace: cellular_component
def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303]
comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
synonym: "coding-region determinant of instability-mediated mRNA stability complex" EXACT []
synonym: "coding-region instability determinant -mediated mRNA stability complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0070938
name: contractile ring
namespace: cellular_component
def: "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]
synonym: "constriction ring" RELATED [GOC:mah]
synonym: "cytokinetic ring" RELATED [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0070939
name: Dsl1/NZR complex
namespace: cellular_component
def: "A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722, PMID:21550981]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
synonym: "CATCHR family complex" BROAD []
synonym: "Dsl1p complex" EXACT [PMID:19151722]
synonym: "NZR complex" EXACT [PMID:25364732]
is_a: GO:0099023 ! vesicle tethering complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:0070940
name: obsolete dephosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "OBSOLETE. The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]
comment: This term was obsoleted because it represents a molecular function.
synonym: "CTD domain dephosphorylation of RNA polymerase II" EXACT [GOC:mah]
synonym: "generation of hypophosphorylated CTD of RNA polymerase II" EXACT [GOC:krc]
synonym: "generation of II(A) form of RNA polymerase II" EXACT [GOC:krc]
is_obsolete: true
consider: GO:0008420

[Term]
id: GO:0070941
name: eisosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane." [GOC:al, GOC:jp, GOC:mah, PMID:19564405]
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0070942
name: neutrophil mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a neutrophil." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002446 ! neutrophil mediated immunity

[Term]
id: GO:0070943
name: neutrophil-mediated killing of symbiont cell
namespace: biological_process
def: "The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated killing of symbiont cell" EXACT []
is_a: GO:0051873 ! killing by host of symbiont cells
is_a: GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070944
name: neutrophil-mediated killing of bacterium
namespace: biological_process
def: "The directed killing of a bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated killing of bacterium" EXACT []
is_a: GO:0070943 ! neutrophil-mediated killing of symbiont cell
relationship: part_of GO:0042742 ! defense response to bacterium

[Term]
id: GO:0070945
name: neutrophil-mediated killing of gram-negative bacterium
namespace: biological_process
def: "The directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated killing of gram-negative bacterium" EXACT []
is_a: GO:0070944 ! neutrophil-mediated killing of bacterium
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium

[Term]
id: GO:0070946
name: neutrophil-mediated killing of gram-positive bacterium
namespace: biological_process
def: "The directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated killing of gram-positive bacterium" EXACT []
is_a: GO:0070944 ! neutrophil-mediated killing of bacterium
relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium

[Term]
id: GO:0070947
name: neutrophil-mediated killing of fungus
namespace: biological_process
def: "The directed killing of a fungal cell by a neutrophil." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated killing of fungus" EXACT []
is_a: GO:0070943 ! neutrophil-mediated killing of symbiont cell
relationship: part_of GO:0050832 ! defense response to fungus

[Term]
id: GO:0070948
name: regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "regulation of neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: regulates GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070949
name: regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
is_a: GO:0051709 ! regulation of killing of cells of another organism
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
relationship: regulates GO:0070943 ! neutrophil-mediated killing of symbiont cell

[Term]
id: GO:0070950
name: regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
relationship: regulates GO:0070944 ! neutrophil-mediated killing of bacterium

[Term]
id: GO:0070951
name: regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
relationship: regulates GO:0070945 ! neutrophil-mediated killing of gram-negative bacterium

[Term]
id: GO:0070952
name: regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
relationship: regulates GO:0070946 ! neutrophil-mediated killing of gram-positive bacterium

[Term]
id: GO:0070953
name: regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:1900150 ! regulation of defense response to fungus
relationship: regulates GO:0070947 ! neutrophil-mediated killing of fungus

[Term]
id: GO:0070954
name: negative regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "negative regulation of neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
relationship: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070955
name: negative regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0051711 ! negative regulation of killing of cells of another organism
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:0070954 ! negative regulation of neutrophil mediated cytotoxicity
relationship: negatively_regulates GO:0070943 ! neutrophil-mediated killing of symbiont cell

[Term]
id: GO:0070956
name: negative regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell
relationship: negatively_regulates GO:0070944 ! neutrophil-mediated killing of bacterium

[Term]
id: GO:0070957
name: negative regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium
is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium
relationship: negatively_regulates GO:0070945 ! neutrophil-mediated killing of gram-negative bacterium

[Term]
id: GO:0070958
name: negative regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium
is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium
relationship: negatively_regulates GO:0070946 ! neutrophil-mediated killing of gram-positive bacterium

[Term]
id: GO:0070959
name: negative regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of fungus" NARROW [GOC:mah]
is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus
is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell
relationship: negatively_regulates GO:0070947 ! neutrophil-mediated killing of fungus

[Term]
id: GO:0070960
name: positive regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "positive regulation of neutrophil mediated cell killing" EXACT [GOC:add]
synonym: "stimulation of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
relationship: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070961
name: positive regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0051712 ! positive regulation of killing of cells of another organism
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:0070960 ! positive regulation of neutrophil mediated cytotoxicity
relationship: positively_regulates GO:0070943 ! neutrophil-mediated killing of symbiont cell

[Term]
id: GO:0070962
name: positive regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell
is_a: GO:1900426 ! positive regulation of defense response to bacterium
relationship: positively_regulates GO:0070944 ! neutrophil-mediated killing of bacterium

[Term]
id: GO:0070963
name: positive regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium
is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium
relationship: positively_regulates GO:0070945 ! neutrophil-mediated killing of gram-negative bacterium

[Term]
id: GO:0070964
name: positive regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium
is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium
relationship: positively_regulates GO:0070946 ! neutrophil-mediated killing of gram-positive bacterium

[Term]
id: GO:0070965
name: positive regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of fungus" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of fungus" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus
is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell
relationship: positively_regulates GO:0070947 ! neutrophil-mediated killing of fungus

[Term]
id: GO:0070966
name: nuclear-transcribed mRNA catabolic process, no-go decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation." [GOC:jp, PMID:16554824]
synonym: "no-go decay" EXACT [GOC:jp]
synonym: "no-go mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, no-go decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA catabolism, no-go decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA degradation, no-go decay" EXACT [GOC:jp]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0070967
name: coenzyme F420 binding
namespace: molecular_function
def: "Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:dh]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097367 ! carbohydrate derivative binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0070968
name: pyrroloquinoline quinone binding
namespace: molecular_function
def: "Binding to pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [GOC:dh]
synonym: "PQQ binding" EXACT [GOC:dh]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0070971
name: endoplasmic reticulum exit site
namespace: cellular_component
def: "An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]
synonym: "ER exit site" EXACT [GOC:mah]
synonym: "transitional ER" EXACT [PMID:15623529]
xref: NIF_Subcellular:sao124393998
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0070972
name: protein localization to endoplasmic reticulum
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]
synonym: "protein localisation in endoplasmic reticulum" EXACT [GOC:mah]
synonym: "protein localization in endoplasmic reticulum" EXACT []
synonym: "protein localization in ER" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0070973
name: protein localization to endoplasmic reticulum exit site
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah]
synonym: "protein localisation to endoplasmic reticulum exit site" EXACT [GOC:mah]
synonym: "protein localization to ER exit site" EXACT [GOC:mah]
is_a: GO:0070972 ! protein localization to endoplasmic reticulum

[Term]
id: GO:0070974
name: POU domain binding
namespace: molecular_function
def: "Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors." [GOC:mah, GOC:yaf, InterPro:IPR000327]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070975
name: FHA domain binding
namespace: molecular_function
def: "Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich." [GOC:mah, InterPro:IPR000253]
synonym: "Forkhead-associated domain binding" EXACT [InterPro:IPR000253]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070976
name: TIR domain binding
namespace: molecular_function
def: "Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]
subset: goslim_chembl
synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070977
name: bone maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah]
is_a: GO:0048799 ! animal organ maturation
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0070978
name: voltage-gated calcium channel complex assembly
namespace: biological_process
def: "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex." [GOC:mh]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0070979
name: protein K11-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0070980
name: biphenyl catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [PMID:16310831, PMID:16339959]
synonym: "biphenyl breakdown" EXACT [GOC:mah]
synonym: "biphenyl catabolism" EXACT [GOC:mah]
synonym: "biphenyl degradation" EXACT [GOC:mah]
is_a: GO:0018879 ! biphenyl metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0070981
name: L-asparagine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [GOC:mah]
synonym: "L-asparagine anabolism" EXACT [GOC:mah]
synonym: "L-asparagine biosynthesis" EXACT [GOC:mah]
synonym: "L-asparagine formation" EXACT [GOC:mah]
synonym: "L-asparagine synthesis" EXACT [GOC:mah]
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0070982 ! L-asparagine metabolic process

[Term]
id: GO:0070982
name: L-asparagine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [GOC:mah]
synonym: "L-asparagine metabolism" EXACT [GOC:mah]
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:0070983
name: dendrite guidance
namespace: biological_process
def: "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
synonym: "dendritic guidance" EXACT [GOC:sart]
is_a: GO:0097485 ! neuron projection guidance
relationship: part_of GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0070984
name: SET domain binding
namespace: molecular_function
def: "Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990]
synonym: "SET binding" EXACT [GOC:sart]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070985
name: transcription factor TFIIK complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993]
synonym: "cyclin H-CDK7 complex" RELATED []
synonym: "Mcs6/Mcs2/Pmh1 complex" NARROW [GOC:vw, PMID:19328067]
synonym: "TFIIK complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
relationship: part_of GO:0005675 ! transcription factor TFIIH holo complex

[Term]
id: GO:0070986
name: left/right axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes)." [GOC:dph, GOC:gvg, GOC:mah]
synonym: "left-right axis specification" EXACT [GOC:mah]
synonym: "left/right axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0060972 ! left/right pattern formation

[Term]
id: GO:0070987
name: error-free translesion synthesis
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh]
comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
is_a: GO:0019985 ! translesion synthesis

[Term]
id: GO:0070988
name: demethylation
namespace: biological_process
def: "The process of removing one or more methyl groups from a molecule." [GOC:BHF, GOC:rl]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0070989
name: oxidative demethylation
namespace: biological_process
def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl]
subset: goslim_chembl
is_a: GO:0070988 ! demethylation

[Term]
id: GO:0070990
name: snRNP binding
namespace: molecular_function
def: "Binding to a small nuclear ribonucleoprotein particle." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0070991
name: medium-chain fatty acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:14477]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "MCAD activity" EXACT [GOC:mah]
xref: EC:1.3.8.7
xref: MetaCyc:RXN-11734
xref: RHEA:14477
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0070992
name: translation initiation complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, GOC:mah]
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0070993
name: translation preinitiation complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah]
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0070994
name: detection of oxidative stress
namespace: biological_process
def: "The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal." [GOC:mah]
is_a: GO:0006979 ! response to oxidative stress

[Term]
id: GO:0070995
name: NADPH oxidation
namespace: biological_process
def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah]
synonym: "NADP (reduced) dehydrogenation" EXACT [GOC:mah]
synonym: "NADP (reduced) oxidation" EXACT [GOC:mah]
synonym: "NADPH dehydrogenation" EXACT [GOC:mah]
synonym: "reduced NADP dehydrogenation" EXACT [GOC:mah]
synonym: "reduced NADP oxidation" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate oxidation" EXACT [GOC:mah]
is_a: GO:0006739 ! NADP metabolic process

[Term]
id: GO:0070996
name: type 1 melanocortin receptor binding
namespace: molecular_function
def: "Binding to a type 1 melanocortin receptor." [GOC:BHF, GOC:mah]
synonym: "type 1 melanocortin receptor ligand" NARROW [GOC:mah]
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0070997
name: obsolete neuron death
namespace: biological_process
def: "OBSOLETE. The process of cell death in a neuron." [GOC:BHF, GOC:mah]
comment: The reason for obsoletion is that this term often represents an assay, or a phenotype and not a GO process.
synonym: "neuron cell death" EXACT [GOC:mah, GOC:rl]
synonym: "neuronal cell death" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0070998
name: sensory perception of gravity
namespace: biological_process
def: "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:mah]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0070999
name: detection of mechanical stimulus involved in sensory perception of gravity
namespace: biological_process
def: "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah]
is_a: GO:0009590 ! detection of gravity
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0070998 ! sensory perception of gravity

[Term]
id: GO:0071000
name: response to magnetism
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl]
synonym: "response to magnetic stimulus" EXACT [GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0071001
name: U4/U6 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897, PMID:14685174]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0071002
name: U4atac/U6atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897, PMID:14685174]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0071003
name: penta-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that is formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:mah, PMID:11804584, PMID:12724403]
synonym: "penta-RNP complex" EXACT [GOC:rb]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0071004
name: U2-type prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]
synonym: "GT-AG prespliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major prespliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "yeast U2-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071010 ! prespliceosome

[Term]
id: GO:0071005
name: U2-type precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "GT-AG precatalytic spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major precatalytic spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U12-type spliceosomal complex A2-1" RELATED [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071011 ! precatalytic spliceosome

[Term]
id: GO:0071006
name: U2-type catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "GT-AG catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "U2-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071012 ! catalytic step 1 spliceosome

[Term]
id: GO:0071007
name: U2-type catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "GT-AG catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071013 ! catalytic step 2 spliceosome

[Term]
id: GO:0071008
name: U2-type post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "GT-AG post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "major post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "U2/U5/U6 snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941, PMID:24442611]
synonym: "U2/U5/U6 tri-snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071014 ! post-mRNA release spliceosomal complex

[Term]
id: GO:0071009
name: U4atac/U6atac x U5 tri-snRNP complex
namespace: cellular_component
def: "A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs." [GOC:krc, GOC:mah, GOC:pr, ISBN:0879695897, PMID:16201866]
synonym: "U4atac/U6atac.U5 snRNP complex" EXACT []
is_a: GO:0097526 ! spliceosomal tri-snRNP complex

[Term]
id: GO:0071010
name: prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]
synonym: "mammalian spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "prespliceosomal complex" EXACT [GOC:vw]
synonym: "yeast spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071011
name: precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "mammalian spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071012
name: catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071013
name: catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "mammalian spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071014
name: post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]
synonym: "mammalian spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071015
name: U12-type prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866]
synonym: "AT-AC prespliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "minor prespliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071010 ! prespliceosome

[Term]
id: GO:0071016
name: U12-type precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:16201866]
synonym: "AT-AC precatalytic spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor precatalytic spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071011 ! precatalytic spliceosome

[Term]
id: GO:0071017
name: U12-type catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "U12-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U12-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071012 ! catalytic step 1 spliceosome

[Term]
id: GO:0071018
name: U12-type catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071013 ! catalytic step 2 spliceosome

[Term]
id: GO:0071019
name: U12-type post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071014 ! post-mRNA release spliceosomal complex

[Term]
id: GO:0071020
name: post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071021
name: U2-type post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "GT-AG post-spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "major post-spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071020 ! post-spliceosomal complex

[Term]
id: GO:0071022
name: U12-type post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "AT-AC post-spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor post-spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071020 ! post-spliceosomal complex

[Term]
id: GO:0071023
name: trans spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates." [GOC:krc, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071024
name: SL snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins." [GOC:krc, ISBN:0879697393]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0071025
name: RNA surveillance
namespace: biological_process
def: "A process that identifies and degrades defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "RNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0071026
name: cytoplasmic RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "cytoplasmic aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "cytoplasmic RNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071025 ! RNA surveillance

[Term]
id: GO:0071027
name: nuclear RNA surveillance
namespace: biological_process
def: "A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear RNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071025 ! RNA surveillance

[Term]
id: GO:0071028
name: nuclear mRNA surveillance
namespace: biological_process
alt_id: GO:0071033
alt_id: GO:0071048
alt_id: GO:0071049
def: "A process that identifies and degrades defective or aberrant mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474]
synonym: "nuclear aberrant mRNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear mRNA quality control" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear retention of pre-mRNA at the site of transcription" NARROW []
synonym: "nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription" NARROW []
synonym: "nuclear retention of unspliced pre-mRNA at the site of transcription" NARROW []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071029
name: obsolete nuclear ncRNA surveillance
namespace: biological_process
def: "OBSOLETE. The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0071027

[Term]
id: GO:0071030
name: nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
namespace: biological_process
def: "The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA quality control of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear RNA catabolic process of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0071031
name: nuclear mRNA surveillance of mRNA 3'-end processing
namespace: biological_process
def: "The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA catabolic process of mRNA with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear mRNA quality control of mRNAs with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0071032
name: nuclear mRNA surveillance of mRNP export
namespace: biological_process
def: "The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA catabolic process of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear mRNA quality control of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0071034
name: CUT catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs)." [GOC:dgf, GOC:krc]
synonym: "cryptic unstable transcript catabolic process" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071043 ! CUT metabolic process

[Term]
id: GO:0071035
name: nuclear polyadenylation-dependent rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA." [GOC:dgf, GOC:krc, PMID:15173578, PMID:15572680, PMID:15935758, PMID:17652137, PMID:18591258]
synonym: "nuclear poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071036
name: nuclear polyadenylation-dependent snoRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA." [GOC:dgf, GOC:krc, PMID:15935758]
synonym: "nuclear poly(A)-dependent snoRNA catabolic process" RELATED [GOC:tb]
is_a: GO:0016077 ! sno(s)RNA catabolic process
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071037
name: nuclear polyadenylation-dependent snRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA." [GOC:dgf, GOC:krc]
synonym: "nuclear poly(A)-dependent snRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0016076 ! snRNA catabolic process
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071038
name: TRAMP-dependent tRNA surveillance pathway
namespace: biological_process
def: "A nuclear tRNA surveillance pathway, dependent on the TRAMP exosome adaptor and the nuclear exosome." [GOC:vw, PMID:35901126]
is_a: GO:0071027 ! nuclear RNA surveillance
is_a: GO:0106354 ! tRNA surveillance

[Term]
id: GO:0071039
name: nuclear polyadenylation-dependent CUT catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258]
synonym: "nuclear poly(A)-dependent CUT catabolic process" RELATED [GOC:vw]
is_a: GO:0071027 ! nuclear RNA surveillance
is_a: GO:0071034 ! CUT catabolic process

[Term]
id: GO:0071040
name: nuclear polyadenylation-dependent antisense transcript catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript." [GOC:dgf, GOC:krc, PMID:18022365]
synonym: "nuclear poly(A)-dependent antisense transcript catabolic process" RELATED [GOC:vw]
is_a: GO:0071041 ! antisense RNA transcript catabolic process

[Term]
id: GO:0071041
name: antisense RNA transcript catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product." [GOC:dgf, GOC:krc]
is_a: GO:0042868 ! antisense RNA metabolic process
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071042
name: nuclear polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]
synonym: "nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0071047 ! polyadenylation-dependent mRNA catabolic process

[Term]
id: GO:0071043
name: CUT metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0071044
name: histone mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA)." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0008334 ! histone mRNA metabolic process

[Term]
id: GO:0071045
name: nuclear histone mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]
is_a: GO:0071044 ! histone mRNA catabolic process

[Term]
id: GO:0071046
name: nuclear polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc, PMID:17410208]
synonym: "nuclear poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071047
name: polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc]
synonym: "poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0006402 ! mRNA catabolic process
is_a: GO:0061157 ! mRNA destabilization

[Term]
id: GO:0071050
name: obsolete sno(s)RNA polyadenylation
namespace: biological_process
def: "OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA class molecule (referred to as an sRNA in Archaea). In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation." [GOC:dgf, GOC:krc, PMID:18951092]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "snoRNA polyadenylation" NARROW []
synonym: "sRNA polyadenylation" NARROW []
is_obsolete: true
replaced_by: GO:0071051

[Term]
id: GO:0071051
name: poly(A)-dependent snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]
synonym: "polyadenylation-dependent snoRNA 3'-end processing" EXACT []
synonym: "sno(s)RNA polyadenylation" NARROW []
is_a: GO:0031126 ! sno(s)RNA 3'-end processing

[Term]
id: GO:0071052
name: alpha9-beta1 integrin-ADAM1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM1 complex" NARROW [CORUM:2964]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071053
name: alpha9-beta1 integrin-ADAM2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM2 complex" NARROW [CORUM:2441]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071054
name: alpha9-beta1 integrin-ADAM3 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM3 complex" NARROW [CORUM:2965]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071055
name: alpha9-beta1 integrin-ADAM9 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM9 complex" NARROW [CORUM:2440]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071056
name: alpha9-beta1 integrin-ADAM15 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM15 complex" NARROW [CORUM:2445]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071057
name: alphav-beta3 integrin-ADAM15 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:10944520, PMID:11882657]
synonym: "ITGAV-ITGB3-ADAM15 complex" NARROW [CORUM:2359]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071058
name: alpha3-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151." [PMID:10811835, PMID:11884516]
synonym: "ITGA3-ITGB1-CD151 complex" NARROW [CORUM:2400]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071059
name: alpha6-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516]
synonym: "ITGA6-ITGB1-CD151 complex" NARROW [CORUM:2411]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071060
name: alpha7-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516]
synonym: "ITGA7-ITGB1-CD151 complex" NARROW [CORUM:2395]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071061
name: alpha6-beta4 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151." [PMID:10811835]
synonym: "ITGA6-ITGB4-CD151 complex" NARROW [CORUM:2320]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071062
name: alphav-beta3 integrin-vitronectin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin." [PMID:10835423]
synonym: "ITGAV-ITGB3-VTN complex" NARROW [CORUM:2826]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071063
name: sensory perception of wind
namespace: biological_process
def: "The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal." [GOC:mah, PMID:19279637]
synonym: "perception of wind" EXACT [GOC:mah]
synonym: "sensory perception of air flow" EXACT [GOC:mah, PMID:19279637]
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0071064
name: alphaE-beta7 integrin-E-cadherin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin." [PMID:10837471]
synonym: "ITGAE-ITGB7-CDH1 complex" NARROW [CORUM:1834]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071065
name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1." [PMID:10209034]
synonym: "ITGA9-ITGB1-VCAM1 complex" NARROW [CORUM:2442]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071066
name: detection of mechanical stimulus involved in sensory perception of wind
namespace: biological_process
def: "The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah, PMID:19279637]
synonym: "detection of mechanical stimulus involved in sensory perception of air flow" EXACT [GOC:mah]
synonym: "detection of wind" EXACT [GOC:mah]
synonym: "perception of wind, detection of mechanical stimulus" EXACT [GOC:mah]
synonym: "perception of wind, sensory detection of mechanical stimulus" EXACT [GOC:mah]
synonym: "perception of wind, sensory transduction of mechanical stimulus" EXACT [GOC:mah]
synonym: "sensory detection of mechanical stimulus during perception of wind" EXACT [GOC:mah]
synonym: "sensory transduction of mechanical stimulus during perception of wind" EXACT [GOC:mah]
synonym: "sensory transduction of wind" EXACT [GOC:mah]
is_a: GO:0050877 ! nervous system process
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0071063 ! sensory perception of wind

[Term]
id: GO:0071067
name: alphav-beta3 integrin-ADAM23 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23." [PMID:10749942]
synonym: "ITGAV-ITGB3-ADAM23 complex" NARROW [CORUM:2364]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071068
name: alpha9-beta1 integrin-ADAM12 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12." [PMID:10944520]
synonym: "ITGA9-ITGB1-ADAM12 complex" NARROW [CORUM:2447]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071069
name: alpha4-beta1 integrin-thrombospondin-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1." [PMID:11980922]
synonym: "ITGA4-ITGB1-THBS1 complex" NARROW [CORUM:2426]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071070
name: alpha4-beta1 integrin-thrombospondin-2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2." [PMID:11980922]
synonym: "ITGA4-ITGB1-THBS2 complex" NARROW [CORUM:2428]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071071
name: regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
synonym: "regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "regulation of phospholipid synthesis" EXACT [GOC:mah]
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: regulates GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0071072
name: negative regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
synonym: "down regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of phospholipid biosynthetic process" EXACT [GOC:ma]
synonym: "downregulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid synthesis" EXACT [GOC:mah]
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
relationship: negatively_regulates GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0071073
name: positive regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
synonym: "activation of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid synthesis" EXACT [GOC:mah]
synonym: "stimulation of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of phospholipid biosynthetic process" EXACT [GOC:mah]
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0071074
name: eukaryotic initiation factor eIF2 binding
namespace: molecular_function
def: "Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0071075
name: CUGBP1-eIF2 complex
namespace: cellular_component
def: "A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation." [PMID:16931514]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0071076
name: RNA 3' uridylation
namespace: biological_process
def: "The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462]
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0071077
name: adenosine 3',5'-bisphosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other." [GOC:mah]
synonym: "adenosine 3',5'-diphosphate transporter activity" EXACT [PubChem_Compound:159296]
synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity" EXACT [PubChem_Compound:159296]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity

[Term]
id: GO:0071078
name: fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion." [PMID:10684262]
synonym: "FN-TGM2 complex" NARROW [CORUM:2375]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071079
name: alpha2-beta1 integrin-chondroadherin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin." [PMID:9281592]
synonym: "ITGA2-ITGB1-CHAD complex" NARROW [CORUM:2430]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071080
name: alpha3-beta1 integrin-basigin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin." [PMID:9360995]
synonym: "ITGA3-ITGB1-BSG complex" NARROW [CORUM:2398]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071081
name: alpha3-beta1 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63." [PMID:7629079]
synonym: "ITGA3-ITGB1-CD63 complex" NARROW [CORUM:2399]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071082
name: alpha9-beta1 integrin-tenascin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin." [PMID:9565552]
synonym: "ITGA9-ITGB1-TNC complex" NARROW [CORUM:2443]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071083
name: alphaV-beta3 integrin-CD47-FCER2 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2)." [PMID:10037797]
synonym: "ITGAV-ITGB3-CD447-FCER2 complex" NARROW [CORUM:2355]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071084
name: alpha2-beta1 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47." [PMID:10397731]
synonym: "ITGA2-ITGB1-CD47 complex" NARROW [CORUM:2429]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071085
name: alphaIIb-beta3 integrin-CD9 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9." [PMID:10429193]
synonym: "ITGA2b-ITGB3-CD9 complex" NARROW [CORUM:2370]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071086
name: alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib." [PMID:10429193]
synonym: "ITGA2b-ITGB3-CD9-GP1b-CD47 complex" NARROW [CORUM:2872]
is_a: GO:0090665 ! glycoprotein complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071087
name: alpha11-beta1 integrin-collagen type I complex
namespace: cellular_component
def: "A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen." [PMID:10464311]
synonym: "ITGA11-ITGB1-COL1A1 complex" NARROW [CORUM:3059]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071088
name: alpha5-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA5-ITGB1-TGM2 complex" NARROW [CORUM:2433]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071089
name: alphaV-beta3 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGAV-ITGB3-TGM2 complex" NARROW [CORUM:3095]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071090
name: alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262]
synonym: "ITGA2b-ITGB3-FN1-TGM2 complex" NARROW [CORUM:2376]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071091
name: alpha1-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA1-ITGB1-TGM2 complex" NARROW [CORUM:2894]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071092
name: alpha3-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA3-ITGB1-TGM2 complex" NARROW [CORUM:2402]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071093
name: alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262]
synonym: "ITGA5-ITGB1-FN1-TGM2 complex" NARROW [CORUM:2383]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0071094
name: alpha6-beta4 integrin-CD9 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9." [PMID:10711425]
synonym: "ITGA6-ITGB4-CD9 complex" NARROW [CORUM:2770]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071095
name: alpha3-beta1 integrin-thrombospondin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin." [PMID:11358957]
synonym: "ITGA3-ITGB1-THBS1 complex" NARROW [CORUM:2401]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071096
name: alphaV-beta3 integrin-gelsolin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin." [PMID:11577104]
synonym: "ITGAV-ITGB3-Gsn complex" NARROW [CORUM:2360]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071097
name: alphaV-beta3 integrin-paxillin-Pyk2 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2." [PMID:11683411]
synonym: "ITGAV-ITGB3-PXN-PTK2b complex" NARROW [CORUM:2363]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071098
name: alpha6-beta4 integrin-Fyn complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn." [PMID:11684709]
synonym: "ITGA6-ITGB4-FYN complex" NARROW [CORUM:2321]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071099
name: alphaV-beta6 integrin-TGFbeta-3 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3)." [PMID:11821050]
synonym: "ITGAV-ITGB6-TFGB3 complex" NARROW [CORUM:2353]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071100
name: alphaV-beta8 integrin-MMP14-TGFbeta-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1)." [PMID:11970960]
synonym: "ITGAV-ITGB8-MMP14-TGFB1 complex" NARROW [CORUM:2342]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071101
name: alpha4-beta1 integrin-JAM2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2." [PMID:12070135]
synonym: "ITGA4-ITGB1-JAM2 complex" NARROW [CORUM:2422]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071102
name: alpha4-beta1 integrin-paxillin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin." [PMID:12221126]
synonym: "ITGA4-ITGB1-PXN complex" NARROW [CORUM:2425]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071103
name: DNA conformation change
namespace: biological_process
def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah]
subset: goslim_metagenomics
synonym: "DNA conformation modification" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0071104
name: response to interleukin-9
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah, GOC:yaf]
synonym: "response to IL-9" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0071105
name: response to interleukin-11
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah, GOC:yaf]
synonym: "response to IL-11" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0071106
name: adenosine 3',5'-bisphosphate transmembrane transport
namespace: biological_process
def: "The process in which adenosine 3',5'-bisphosphate is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "adenosine 3',5'-bisphosphate membrane transport" EXACT []
synonym: "adenosine 3',5'-diphosphate transport" EXACT [PubChem_Compound:159296]
synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transport" EXACT [PubChem_Compound:159296]
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:0071107
name: response to parathyroid hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah, GOC:yaf]
synonym: "response to parathyroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0071108
name: protein K48-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0071109
name: superior temporal gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus." [FMA:61905, GOC:BHF, GOC:mah, PMID:11484000]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0071110
name: obsolete histone biotinylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
comment: This terms was obsoleted because it represents a molecular function as a biological process.
is_obsolete: true

[Term]
id: GO:0071111
name: cyclic-guanylate-specific phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+." [EC:3.1.4.52, RHEA:24902]
synonym: "c-di-GMP phosphodiesterase activity" RELATED [EC:3.1.4.52]
synonym: "c-di-GMP-specific phosphodiesterase activity" RELATED [EC:3.1.4.52]
synonym: "cyclic bis(3->5')diguanylate phosphodiesterase activity" RELATED [EC:3.1.4.52]
synonym: "PDEA1" RELATED [EC:3.1.4.52]
synonym: "phosphodiesterase A1 activity" RELATED [EC:3.1.4.52]
synonym: "VieA" RELATED [EC:3.1.4.52]
xref: EC:3.1.4.52
xref: KEGG_REACTION:R08991
xref: MetaCyc:RXN0-4181
xref: RHEA:24902
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0071112
name: alpha4-beta4 integrin-EMILIN-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN)." [PMID:12456677]
synonym: "ITGA4-ITGB4-EMILIN1 complex" NARROW [CORUM:2417]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071113
name: alphaIIb-beta3 integrin-ICAM-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4." [PMID:12477717]
synonym: "ITGAIIb-ITGB3-ICAM4 complex" NARROW [CORUM:3115]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071114
name: alphaV-beta3 integrin-tumstatin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen." [PMID:12682293]
synonym: "ITGAV-ITGB3-COL4A3 complex" NARROW [CORUM:2365]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071115
name: alpha5-beta1 integrin-endostatin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen." [PMID:12682293]
synonym: "ITGA5-ITGB1-CAL4A3 complex" NARROW [CORUM:2853]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071116
name: alpha6-beta1 integrin-CYR61 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis." [PMID:12826661]
synonym: "ITGA6-ITGB1-CYR61 complex" NARROW [CORUM:2437]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071117
name: alpha5-beta1 integrin-fibronectin-NOV complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV." [PMID:12902636]
synonym: "ITGA5-ITGB1-FN-1-NOV complex" NARROW [CORUM:2850]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071118
name: alphaV-beta3 integrin-NOV complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV." [PMID:12902636]
synonym: "ITGAV-ITGB3-FN-1-NOV complex" NARROW [CORUM:2849]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071119
name: alpha7-beta1 integrin-nicotinamide riboside kinase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP)." [PMID:12941630]
synonym: "ITGA7-ITGB1-ITGB1BP3 complex" NARROW [CORUM:2397]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071120
name: alpha4-beta1 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47." [PMID:15292185]
synonym: "ITGA4-ITGB1-CB47 complex" NARROW [CORUM:2423]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071121
name: alpha9-beta1 integrin-VEGF-D complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D." [PMID:15590642]
synonym: "ITGA9-ITGB1-FIGF complex" NARROW [CORUM:2446]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071122
name: alpha9-beta1 integrin-VEGF-A complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A." [PMID:17363377]
synonym: "ITGA9-ITGB1-VEGFA complex" NARROW [CORUM:2972]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071123
name: alpha9-beta1 integrin-VEGF-C complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C." [PMID:15590642]
synonym: "ITGA9-ITGB1-VEGFC complex" NARROW [CORUM:2971]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071124
name: alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2." [PMID:15592458]
synonym: "ITGA1-ITGB1-PTPN2 complex" NARROW [CORUM:2435]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071125
name: alphaV-beta3 integrin-EGFR complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor." [PMID:15834425]
synonym: "ITGAV-ITGB3-EGFR complex" NARROW [CORUM:2369]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071126
name: alphaV-beta6 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGAV-ITGB6-SPP1 complex" NARROW [CORUM:2352]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071127
name: alpha9-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGA9-ITGB1-SPP1 complex" NARROW [CORUM:3111]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071128
name: alpha5-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGA5-ITGB1-SPP1 complex" NARROW [CORUM:3112]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071129
name: alphaV-beta3 integrin-LPP3 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422]
synonym: "ITGAV-ITGB3-PPAP2B complex" NARROW [CORUM:2366]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071130
name: alpha5-beta1 integrin-LPP3 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422]
synonym: "ITGA5-ITGB1-PPAP2B complex" NARROW [CORUM:2386]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071131
name: alphaV-beta3 integrin-laminin alpha-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4." [PMID:16824487]
synonym: "ITGAV-ITGB3-LAMA4 complex" NARROW [CORUM:2374]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071132
name: alphaX-beta2 integrin-ICAM-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4." [PMID:16985175]
synonym: "ITGAX-ITGB2-ICAM4 complex" NARROW [CORUM:3114]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071133
name: alpha9-beta1 integrin-ADAM8 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8." [PMID:16995821]
synonym: "ITGA9-ITGB1-ADAM8 complex" NARROW [CORUM:2989]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071134
name: alpha9-beta1 integrin-thrombospondin-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1." [PMID:17413041]
synonym: "ITGA9-ITGB1-THBS1 complex" NARROW [CORUM:2967]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071135
name: alpha7-beta1 integrin-focal adhesion kinase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase." [PMID:17598176]
synonym: "ITGA7-ITGB1-PTK2 complex" NARROW [CORUM:3106]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071136
name: alpha7-beta1 integrin-laminin alpha-2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2." [PMID:17598176]
synonym: "ITGA7-ITGB1-LAMA2 complex" NARROW [CORUM:3105]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071137
name: alphaV-beta3 integrin-CD98 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98." [PMID:18032696]
synonym: "ITGAV-ITGB3-SLC3A2 complex" NARROW [CORUM:3103]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071138
name: alpha5-beta5-fibronectin-SFRP2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2." [PMID:14709558]
synonym: "ITGA5-ITGB5-FN-1-SFRP2 complex" NARROW [CORUM:2388]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071139
name: resolution of DNA recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw]
synonym: "resolution of recombination intermediates" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0071140
name: resolution of mitotic recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw]
is_a: GO:0071139 ! resolution of DNA recombination intermediates
relationship: part_of GO:0006312 ! mitotic recombination

[Term]
id: GO:0071141
name: SMAD protein complex
namespace: cellular_component
def: "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020]
synonym: "SMAD complex" EXACT [GOC:mah]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0071142
name: homomeric SMAD protein complex
namespace: cellular_component
alt_id: GO:0071143
def: "A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive." [GOC:bhm, GOC:mah, PMID:11779505, PMID:16322555, PMID:9670020]
synonym: "SMAD1 homotrimer complex" NARROW []
synonym: "SMAD1 protein complex" NARROW []
synonym: "SMAD2 homotrimer complex" NARROW []
synonym: "SMAD2 protein complex" NARROW []
synonym: "SMAD3 homotrimer complex" NARROW [CORUM:3003]
synonym: "SMAD3 protein complex" NARROW []
is_a: GO:0071141 ! SMAD protein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0071144
name: heteromeric SMAD protein complex
namespace: cellular_component
alt_id: GO:0071145
alt_id: GO:0071146
def: "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]
synonym: "SMAD1-SMAD4 protein complex" NARROW []
synonym: "SMAD2-SMAD3-SMAD4 protein complex" NARROW []
synonym: "SMAD2-SMAD4 protein complex" NARROW [CORUM:3001]
synonym: "SMAD3-SMAD4 protein complex" NARROW []
is_a: GO:0071141 ! SMAD protein complex
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0071152
name: G-protein alpha(q)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(q) alpha subunit complex" NARROW [CORUM:175]
is_a: GO:0140535 ! intracellular protein-containing complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0071153
name: G-protein alpha(o)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(o) alpha-1 subunit complex" NARROW [CORUM:172]
synonym: "Ric-8A G(o) alpha-2 subunit complex" NARROW [CORUM:174]
is_a: GO:0140535 ! intracellular protein-containing complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0071154
name: G-protein alpha(i)1-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(i) alpha-1 subunit complex" NARROW [CORUM:170]
synonym: "Ric-8A G(i) alpha-2 subunit complex" RELATED [CORUM:171]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0071155
name: G-protein alpha(13)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G alpha 13 subunit complex" NARROW [CORUM:176]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0071159
name: NF-kappaB complex
namespace: cellular_component
def: "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071160
name: cyanophycin synthetase activity (L-aspartate-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29]
xref: EC:6.3.2.29
xref: RHEA:13277
is_a: GO:0043860 ! cyanophycin synthetase activity

[Term]
id: GO:0071161
name: cyanophycin synthetase activity (L-arginine-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30]
xref: EC:6.3.2.30
xref: RHEA:23888
is_a: GO:0043860 ! cyanophycin synthetase activity

[Term]
id: GO:0071162
name: CMG complex
namespace: cellular_component
def: "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]
synonym: "unwindosome" EXACT [PMID:19228417]
is_a: GO:0031261 ! DNA replication preinitiation complex
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0071163
name: DNA replication preinitiation complex assembly
namespace: biological_process
alt_id: GO:1902293
alt_id: GO:1902316
def: "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641]
synonym: "DNA replication preinitiation complex formation" EXACT [GOC:mah]
synonym: "pre-IC complex assembly" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0071164
name: RNA cap trimethylguanosine synthase activity
namespace: molecular_function
def: "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [PMID:11983179, PMID:18775984]
comment: A 2,2,7-trimethylguanosine (TMG) cap is found on many RNA polymerase II transcribed small noncoding RNAs including small nuclear RNA (snRNA), small nucleolar RNA (snoRNA) and telomerase RNA. It is also found on nematode mRNAs that undergo trans-splicing of a 5'-capped leader sequence.
synonym: "cap hypermethylase activity" EXACT [PMID:11983179]
synonym: "RNA trimethylguanosine synthase activity" EXACT []
synonym: "small nuclear RNA methyltransferase activity" RELATED [GOC:rl]
synonym: "snRNA methyltransferase activity" RELATED [GOC:rl]
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0071165
name: GINS complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks." [GOC:mah, PMID:16990792]
is_a: GO:0071163 ! DNA replication preinitiation complex assembly

[Term]
id: GO:0071166
name: ribonucleoprotein complex localization
namespace: biological_process
def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah]
synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "RNP localization" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0071167
name: obsolete ribonucleoprotein complex import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus." [GOC:BHF, GOC:mah]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "ribonucleoprotein complex import into cell nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex nucleus import" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex targeting to nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex transport from cytoplasm to nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein import into nucleus" EXACT [GOC:rl]
synonym: "RNP import into nucleus" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0071168
name: protein localization to chromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0071169
name: establishment of protein localization to chromatin
namespace: biological_process
def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0070199 ! establishment of protein localization to chromosome
is_a: GO:0071168 ! protein localization to chromatin

[Term]
id: GO:0071170
name: site-specific DNA replication termination
namespace: biological_process
def: "A DNA replication termination process that takes place at a specific termination site." [GOC:mah, PMID:12009298, PMID:18723894]
comment: See also the biological process term 'replication fork arrest ; GO:0043111' and its children.
is_a: GO:0006274 ! DNA replication termination

[Term]
id: GO:0071171
name: site-specific DNA replication termination at RTS1 barrier
namespace: biological_process
def: "A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching." [GOC:vw, PMID:12009298, PMID:18723894]
is_a: GO:0071170 ! site-specific DNA replication termination
relationship: part_of GO:0071515 ! mating-type locus imprinting

[Term]
id: GO:0071172
name: dihydromonapterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+." [GOC:imk, PMID:19897652]
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0071173
name: spindle assembly checkpoint signaling
namespace: biological_process
alt_id: GO:0072486
def: "A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic).
subset: gocheck_do_not_annotate
synonym: "SAC" BROAD [GOC:mah]
synonym: "signal transduction involved in spindle assembly checkpoint" EXACT []
synonym: "spindle assembly checkpoint" EXACT []
is_a: GO:0031577 ! spindle checkpoint signaling

[Term]
id: GO:0071174
name: mitotic spindle checkpoint signaling
namespace: biological_process
alt_id: GO:0072477
def: "A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints).
subset: gocheck_do_not_annotate
synonym: "mitotic cell cycle spindle checkpoint" EXACT []
synonym: "mitotic spindle checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cell cycle spindle checkpoint" EXACT []
synonym: "signal transduction involved in mitotic spindle checkpoint" EXACT []
synonym: "topo II checkpoint" RELATED []
synonym: "topoisomerase II checkpoint" RELATED []
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling
is_a: GO:0031577 ! spindle checkpoint signaling

[Term]
id: GO:0071175
name: MAML2-RBP-Jkappa-ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch1 complex" EXACT [CORUM:1949]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071176
name: MAML2-RBP-Jkappa-ICN2 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3217]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071177
name: MAML2-RBP-Jkappa-ICN3 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3218]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071178
name: MAML2-RBP-Jkappa-ICN4 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3219]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071179
name: MAML3-RBP-Jkappa-ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch1 complex" EXACT [CORUM:3220]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071180
name: MAML3-RBP-Jkappa-ICN2 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3221]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071181
name: MAML3-RBP-Jkappa-ICN3 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3222]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071182
name: MAML3-RBP-Jkappa-ICN4 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3223]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071183
name: protocadherin-alpha-protocadherin-gamma complex
namespace: cellular_component
def: "A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0071184
name: protocadherin-alpha-v4-protocadherin-gamma-a1 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdha4 complex" NARROW [CORUM:1014]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071185
name: protocadherin-alpha-v4-protocadherin-gamma-a3 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhga3 complex" NARROW [CORUM:1016]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071186
name: protocadherin-alpha-v4-protocadherin-gamma-b2 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhgb2 complex" NARROW [CORUM:1015]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071187
name: protocadherin-alpha-v4-protocadherin-gamma-b4 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhgb4 complex" NARROW [CORUM:1017]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071188
name: protocadherin-alpha-v7-protocadherin-gamma-a1 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhga1 complex" NARROW [CORUM:1021]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071189
name: protocadherin-alpha-v7-protocadherin-gamma-a3 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhga3 complex" NARROW [CORUM:1019]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071190
name: protocadherin-alpha-v7-protocadherin-gamma-b2 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhgb4 complex" NARROW [CORUM:1018]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071191
name: protocadherin-alpha-v7-protocadherin-gamma-b4 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhgb2 complex" NARROW [CORUM:1020]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071192
name: Kv4.2-KChIP1 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:606
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071193
name: Kv4.2-KChIP2 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:607
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071194
name: Kv4.2-KChIP3 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:608
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071195
name: Kv4.2-KChIP4 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:3090
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071196
name: Kv4.3-KChIP1 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15356203]
xref: CORUM:3091
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071197
name: Kv4.2-Kv4.3 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3." [PMID:15356203]
xref: CORUM:609
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071198
name: Kv4.1-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355]
synonym: "Kv4.1-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:600
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071199
name: Kv4.1-DPP10 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355]
synonym: "Kv4.1-DPPY channel complex" EXACT [PMID:15911355]
xref: CORUM:601
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071200
name: Kv4.2-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:12575952, PMID:15911355]
synonym: "Kv4.2-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:603
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071201
name: Kv4.3-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:12575952, PMID:15911355]
synonym: "Kv4.3-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:599
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071202
name: Kv4.3-DPP10 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15911355]
synonym: "Kv4.3-DPPY channel complex" EXACT [PMID:15911355]
xref: CORUM:598
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071203
name: WASH complex
namespace: cellular_component
def: "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0071204
name: histone pre-mRNA 3'end processing complex
namespace: cellular_component
def: "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752]
synonym: "histone 3'end pre-mRNA complex" EXACT [GOC:mah]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0071205
name: protein localization to juxtaparanode region of axon
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon." [GOC:BHF, GOC:mah]
synonym: "protein localisation to juxtaparanode region of axon" EXACT [GOC:mah]
is_a: GO:0099612 ! protein localization to axon

[Term]
id: GO:0071206
name: establishment of protein localization to juxtaparanode region of axon
namespace: biological_process
def: "The directed movement of a protein to the juxtaparanode region of an axon." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to juxtaparanode region of axon" EXACT [GOC:mah]
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071205 ! protein localization to juxtaparanode region of axon

[Term]
id: GO:0071207
name: histone pre-mRNA stem-loop binding
namespace: molecular_function
def: "Binding to a conserved stem-loop structure found in histone pre-mRNAs." [PMID:19470752]
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0071208
name: histone pre-mRNA DCP binding
namespace: molecular_function
def: "Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing." [PMID:19470752]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0071209
name: U7 snRNA binding
namespace: molecular_function
def: "Binding to a U7 small nuclear RNA (U7 snRNA)." [GOC:mah, PMID:12975319]
comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0071210
name: protein insertion into membrane raft
namespace: biological_process
def: "The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah]
synonym: "establishment of protein localization to membrane raft" BROAD [GOC:mah, GOC:vw]
is_a: GO:0051205 ! protein insertion into membrane
is_a: GO:1903044 ! protein localization to membrane raft
relationship: part_of GO:0031579 ! membrane raft organization

[Term]
id: GO:0071211
name: protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm." [GOC:mah]
synonym: "protein targeting to autophagosome" RELATED [GOC:pad]
is_a: GO:0006623 ! protein targeting to vacuole
relationship: part_of GO:0006914 ! autophagy

[Term]
id: GO:0071212
name: subsynaptic reticulum
namespace: cellular_component
def: "An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]
synonym: "SSR" EXACT [PMID:19244343]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0061174 ! type I terminal bouton

[Term]
id: GO:0071213
name: cellular response to 1-aminocyclopropane-1-carboxylic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:mah]
is_a: GO:0009961 ! response to 1-aminocyclopropane-1-carboxylic acid
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071214
name: cellular response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cellular response to abiotic stress" NARROW [GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0104004 ! cellular response to environmental stimulus

[Term]
id: GO:0071215
name: cellular response to abscisic acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah]
is_a: GO:0009737 ! response to abscisic acid
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol

[Term]
id: GO:0071216
name: cellular response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cellular response to biotic stress" NARROW [GOC:mah]
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0071217
name: cellular response to external biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:mah]
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071496 ! cellular response to external stimulus

[Term]
id: GO:0071218
name: cellular response to misfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]
is_a: GO:0035967 ! cellular response to topologically incorrect protein
is_a: GO:0051788 ! response to misfolded protein

[Term]
id: GO:0071219
name: cellular response to molecule of bacterial origin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:mah]
synonym: "cellular response to bacteria associated molecule" EXACT [GOC:mah]
synonym: "cellular response to bacterial associated molecule" EXACT [GOC:mah]
synonym: "cellular response to bacterium associated molecule" EXACT [GOC:mah]
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0071220
name: cellular response to bacterial lipoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:mah]
is_a: GO:0032493 ! response to bacterial lipoprotein
is_a: GO:0071219 ! cellular response to molecule of bacterial origin

[Term]
id: GO:0071221
name: cellular response to bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:mah]
is_a: GO:0070339 ! response to bacterial lipopeptide
is_a: GO:0071220 ! cellular response to bacterial lipoprotein

[Term]
id: GO:0071222
name: cellular response to lipopolysaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]
synonym: "cellular response to endotoxin" BROAD [GOC:mah, GOC:sl]
synonym: "cellular response to LPS" EXACT [GOC:mah]
is_a: GO:0032496 ! response to lipopolysaccharide
is_a: GO:0071219 ! cellular response to molecule of bacterial origin
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071223
name: cellular response to lipoteichoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:mah]
synonym: "cellular response to LTA" EXACT [GOC:mah]
is_a: GO:0070391 ! response to lipoteichoic acid
is_a: GO:0071219 ! cellular response to molecule of bacterial origin
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071224
name: cellular response to peptidoglycan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:mah]
is_a: GO:0032494 ! response to peptidoglycan
is_a: GO:0071219 ! cellular response to molecule of bacterial origin
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071225
name: cellular response to muramyl dipeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah]
is_a: GO:0032495 ! response to muramyl dipeptide
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071226
name: cellular response to molecule of fungal origin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:mah]
synonym: "cellular response to fungus associated molecule" EXACT [GOC:mah]
is_a: GO:0002238 ! response to molecule of fungal origin
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0071227
name: cellular response to molecule of oomycetes origin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:mah]
synonym: "cellular response to oomycetes associated molecule" EXACT [GOC:mah]
is_a: GO:0002240 ! response to molecule of oomycetes origin
is_a: GO:0071216 ! cellular response to biotic stimulus
relationship: part_of GO:0009620 ! response to fungus

[Term]
id: GO:0071228
name: cellular response to tumor cell
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:mah]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0071229
name: cellular response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, Wikipedia:Acid]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead.
subset: gocheck_do_not_annotate
synonym: "cellular response to acid" BROAD []
synonym: "cellular response to acid anion" RELATED []
synonym: "cellular response to oxoanion" RELATED []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071230
name: cellular response to amino acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]
synonym: "cellular response to amino acid" EXACT [GOC:mah]
is_a: GO:0043200 ! response to amino acid
is_a: GO:0071229 ! cellular response to acid chemical

[Term]
id: GO:0071231
name: cellular response to folic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah]
synonym: "response to folate" EXACT [GOC:mah]
synonym: "response to vitamin B9" EXACT [GOC:mah]
is_a: GO:0051593 ! response to folic acid
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071232
name: cellular response to histidine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080052 ! response to histidine
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071233
name: cellular response to L-leucine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus." [GOC:mah]
synonym: "cellular response to leucine" BROAD []
is_a: GO:0043201 ! response to L-leucine
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071234
name: cellular response to phenylalanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080053 ! response to phenylalanine
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071235
name: cellular response to proline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:mah]
is_a: GO:0010238 ! response to proline
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071236
name: cellular response to antibiotic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:mah]
is_a: GO:0046677 ! response to antibiotic
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071237
name: cellular response to bacteriocin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [GOC:mah]
is_a: GO:0046678 ! response to bacteriocin
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071238
name: cellular response to brefeldin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah]
is_a: GO:0031001 ! response to brefeldin A
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071239
name: cellular response to streptomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah]
is_a: GO:0046679 ! response to streptomycin
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071240
name: cellular response to food
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:mah]
is_a: GO:0032094 ! response to food
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071241
name: obsolete cellular response to inorganic substance
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0071242
name: cellular response to ammonium ion
namespace: biological_process
alt_id: GO:1903718
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
synonym: "cellular response to ammonia" EXACT []
is_a: GO:0060359 ! response to ammonium ion
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071243
name: cellular response to arsenic-containing substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah]
synonym: "cellular response to arsenic" EXACT []
is_a: GO:0046685 ! response to arsenic-containing substance
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071244
name: cellular response to carbon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah]
is_a: GO:0010037 ! response to carbon dioxide
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071245
name: cellular response to carbon monoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah]
is_a: GO:0034465 ! response to carbon monoxide
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071246
name: cellular response to chlorate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah]
is_a: GO:0010157 ! response to chlorate
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071247
name: cellular response to chromate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [GOC:mah]
is_a: GO:0046687 ! response to chromate
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071248
name: cellular response to metal ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]
synonym: "cellular response to heavy metal" NARROW [GOC:mah]
synonym: "cellular response to metal" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071249
name: cellular response to nitrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah]
is_a: GO:0010167 ! response to nitrate
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902170 ! cellular response to reactive nitrogen species

[Term]
id: GO:0071250
name: cellular response to nitrite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:mah]
is_a: GO:0080033 ! response to nitrite
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902170 ! cellular response to reactive nitrogen species

[Term]
id: GO:0071251
name: cellular response to silicon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:mah]
synonym: "cellular response to silica" EXACT [GOC:mah]
synonym: "cellular response to silox" EXACT [GOC:mah]
is_a: GO:0034021 ! response to silicon dioxide
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071252
name: cellular response to sulfur dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [GOC:mah]
is_a: GO:0010477 ! response to sulfur dioxide
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071253
name: connexin binding
namespace: molecular_function
def: "Binding to a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0071254
name: cytoplasmic U snRNP body
namespace: cellular_component
def: "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]
synonym: "U body" EXACT [GOC:sart, PMID:17595295]
synonym: "U-body" EXACT [GOC:mah]
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0071255
name: Cvt vesicle assembly
namespace: biological_process
def: "A vesicle organization process that takes place as part of the Cvt pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI)." [GOC:rb, PMID:10966461, PMID:11085977]
synonym: "Cvt vesicle biosynthesis" RELATED [GOC:mah]
synonym: "Cvt vesicle formation" EXACT [GOC:mah]
synonym: "cytoplasm to vacuole targeting vesicle assembly" EXACT []
synonym: "cytoplasm-to-vacuole targetin vesicle assembly" EXACT []
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0032258 ! cytoplasm to vacuole targeting by the Cvt pathway

[Term]
id: GO:0071256
name: translocon complex
namespace: cellular_component
alt_id: GO:0031206
def: "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins." [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571]
subset: goslim_pir
synonym: "Sec complex-associated translocon complex" NARROW [GOC:mah]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0071257
name: cellular response to electrical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:mah]
synonym: "cellular response to electricity" RELATED [GOC:mah]
is_a: GO:0051602 ! response to electrical stimulus
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071258
name: cellular response to gravity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:mah]
synonym: "cellular response to gravitational stimulus" EXACT [GOC:mah]
is_a: GO:0009629 ! response to gravity
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071259
name: cellular response to magnetism
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah]
synonym: "cellular response to magnetic stimulus" EXACT [GOC:mah]
is_a: GO:0071000 ! response to magnetism
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071260
name: cellular response to mechanical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:mah]
synonym: "cellular mechanical stimulus response" EXACT [GOC:mah]
is_a: GO:0009612 ! response to mechanical stimulus
is_a: GO:0071214 ! cellular response to abiotic stimulus
is_a: GO:0071496 ! cellular response to external stimulus

[Term]
id: GO:0071261
name: Ssh1 translocon complex
namespace: cellular_component
def: "A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences." [GOC:mah, PMID:12134063, PMID:8612571]
synonym: "Ssh1p-Sss1p-Sbh2p complex" NARROW [GOC:mah]
is_a: GO:0071256 ! translocon complex

[Term]
id: GO:0071262
name: regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw]
is_a: GO:0043558 ! regulation of translational initiation in response to stress
relationship: part_of GO:0009267 ! cellular response to starvation

[Term]
id: GO:0071263
name: negative regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "down regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "down-regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "downregulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "inhibition of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "negative regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0071262 ! regulation of translational initiation in response to starvation

[Term]
id: GO:0071264
name: positive regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "activation of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "positive regulation of translational initiation in response to nutrient starvation" EXACT [GOC:mah]
synonym: "stimulation of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "up regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "up-regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "upregulation of translation initiation in response to starvation" EXACT [GOC:mah]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0071262 ! regulation of translational initiation in response to starvation

[Term]
id: GO:0071265
name: L-methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid." [GOC:ecd]
synonym: "L-methionine anabolism" EXACT [GOC:mah]
synonym: "L-methionine biosynthesis" EXACT [GOC:mah]
synonym: "L-methionine formation" EXACT [GOC:mah]
synonym: "L-methionine synthesis" EXACT [GOC:mah]
is_a: GO:0009086 ! methionine biosynthetic process

[Term]
id: GO:0071266
name: 'de novo' L-methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components." [GOC:ecd]
synonym: "'de novo' L-methionine anabolism" EXACT [GOC:mah]
synonym: "'de novo' L-methionine biosynthesis" EXACT [GOC:mah]
synonym: "'de novo' L-methionine formation" EXACT [GOC:mah]
synonym: "'de novo' L-methionine synthesis" EXACT [GOC:mah]
is_a: GO:0071265 ! L-methionine biosynthetic process

[Term]
id: GO:0071267
name: L-methionine salvage
namespace: biological_process
def: "Any process that generates L-methionine from derivatives of it, without de novo synthesis." [GOC:ecd]
is_a: GO:0043102 ! amino acid salvage
is_a: GO:0071265 ! L-methionine biosynthetic process

[Term]
id: GO:0071268
name: homocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid." [GOC:ecd, GOC:mah]
synonym: "homocysteine anabolism" EXACT [GOC:mah]
synonym: "homocysteine biosynthesis" EXACT [GOC:mah]
synonym: "homocysteine formation" EXACT [GOC:mah]
synonym: "homocysteine synthesis" EXACT [GOC:mah]
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0050667 ! homocysteine metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0071269
name: L-homocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid." [GOC:ecd, GOC:mah]
synonym: "L-homocysteine anabolism" EXACT [GOC:mah]
synonym: "L-homocysteine biosynthesis" EXACT [GOC:mah]
synonym: "L-homocysteine formation" EXACT [GOC:mah]
synonym: "L-homocysteine synthesis" EXACT [GOC:mah]
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0071268 ! homocysteine biosynthetic process

[Term]
id: GO:0071270
name: 1-butanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O." [GOC:ecd, GOC:mah]
synonym: "1-butanol metabolism" EXACT [GOC:mah]
synonym: "butan-1-ol metabolic process" EXACT [CHEBI:28885]
synonym: "butanol metabolic process" BROAD [GOC:mah]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:0071271
name: 1-butanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O." [GOC:ecd, GOC:mah]
synonym: "1-butanol anabolism" EXACT [GOC:mah]
synonym: "1-butanol biosynthesis" EXACT [GOC:mah]
synonym: "1-butanol formation" EXACT [GOC:mah]
synonym: "1-butanol synthesis" EXACT [GOC:mah]
synonym: "butan-1-ol biosynthetic process" EXACT [CHEBI:28885]
synonym: "butanol biosynthetic process" BROAD [GOC:mah]
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0071270 ! 1-butanol metabolic process
is_a: GO:1903175 ! fatty alcohol biosynthetic process

[Term]
id: GO:0071272
name: morphine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:mah]
synonym: "morphine metabolism" EXACT [GOC:mah]
xref: Wikipedia:Morphine
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:0071273
name: morphine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:ecd, GOC:mah, PMID:22193538]
synonym: "morphine breakdown" EXACT [GOC:mah]
synonym: "morphine catabolism" EXACT [GOC:mah]
synonym: "morphine degradation" EXACT [GOC:mah]
is_a: GO:0071272 ! morphine metabolic process
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process

[Term]
id: GO:0071274
name: isoquinoline alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, PMID:23666088]
synonym: "ipecac alkaloid catabolism" RELATED [GOC:mah]
synonym: "isoquinoline alkaloid breakdown" EXACT [GOC:mah]
synonym: "isoquinoline alkaloid catabolism" EXACT [GOC:mah]
synonym: "isoquinoline alkaloid degradation" EXACT [GOC:mah]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0071275
name: cellular response to aluminum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:mah]
synonym: "cellular response to aluminium ion" EXACT [GOC:mah]
synonym: "cellular response to aluminum" EXACT [GOC:mah]
is_a: GO:0010044 ! response to aluminum ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071276
name: cellular response to cadmium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah]
synonym: "cellular response to cadmium" EXACT [GOC:mah]
is_a: GO:0046686 ! response to cadmium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071277
name: cellular response to calcium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]
synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah]
is_a: GO:0051592 ! response to calcium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071278
name: cellular response to cesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:mah]
synonym: "cellular response to cesium" EXACT [GOC:mah]
is_a: GO:0010164 ! response to cesium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071279
name: cellular response to cobalt ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah]
is_a: GO:0032025 ! response to cobalt ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071280
name: cellular response to copper ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:mah]
synonym: "cellular response to copper" EXACT [GOC:mah]
is_a: GO:0046688 ! response to copper ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071281
name: cellular response to iron ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah]
synonym: "cellular response to iron" EXACT [GOC:mah]
is_a: GO:0010039 ! response to iron ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071282
name: cellular response to iron(II) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:mah]
synonym: "cellular response to iron(II)" EXACT [GOC:mah]
is_a: GO:0010040 ! response to iron(II) ion
is_a: GO:0071281 ! cellular response to iron ion

[Term]
id: GO:0071283
name: cellular response to iron(III) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:mah]
synonym: "cellular response to iron(III)" EXACT [GOC:mah]
is_a: GO:0010041 ! response to iron(III) ion
is_a: GO:0071281 ! cellular response to iron ion

[Term]
id: GO:0071284
name: cellular response to lead ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:mah]
is_a: GO:0010288 ! response to lead ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071285
name: cellular response to lithium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:mah]
is_a: GO:0010226 ! response to lithium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071286
name: cellular response to magnesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah]
is_a: GO:0032026 ! response to magnesium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071287
name: cellular response to manganese ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:mah]
synonym: "cellular response to manganese" EXACT [GOC:mah]
is_a: GO:0010042 ! response to manganese ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071288
name: cellular response to mercury ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:mah]
synonym: "cellular response to mercuric ion" EXACT [GOC:mah]
synonym: "cellular response to mercury" EXACT [GOC:mah]
is_a: GO:0046689 ! response to mercury ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071289
name: cellular response to nickel ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:mah]
synonym: "cellular response to nickel" EXACT [GOC:mah]
is_a: GO:0010045 ! response to nickel cation
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071290
name: cellular response to platinum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:mah]
synonym: "cellular response to platinum" EXACT [GOC:mah]
is_a: GO:0070541 ! response to platinum ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071291
name: cellular response to selenium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mah]
is_a: GO:0010269 ! response to selenium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071292
name: cellular response to silver ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver (Ag+) ion stimulus." [GOC:mah]
is_a: GO:0010272 ! response to silver ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071293
name: cellular response to tellurium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:mah]
synonym: "cellular response to tellurium" EXACT [GOC:mah]
is_a: GO:0046690 ! response to tellurium ion
is_a: GO:0071248 ! cellular response to metal ion
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071294
name: cellular response to zinc ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:mah]
synonym: "cellular response to zinc" EXACT [GOC:mah]
is_a: GO:0010043 ! response to zinc ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071295
name: cellular response to vitamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:mah]
is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0071296
name: cellular response to biotin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:mah]
synonym: "cellular response to Bios IIB" EXACT [GOC:sl]
synonym: "cellular response to coenzyme R" EXACT [GOC:sl]
synonym: "cellular response to vitamin B7" EXACT [GOC:sl]
synonym: "cellular response to vitamin H" EXACT [GOC:sl]
is_a: GO:0070781 ! response to biotin
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071297
name: cellular response to cobalamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah]
synonym: "cellular response to vitamin B12" EXACT [GOC:mah]
is_a: GO:0033590 ! response to cobalamin
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071298
name: cellular response to L-ascorbic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:mah]
synonym: "cellular response to ascorbic acid" BROAD [GOC:mah]
synonym: "cellular response to L-ascorbate" EXACT [GOC:mah]
synonym: "cellular response to vitamin C" EXACT [GOC:mah]
is_a: GO:0033591 ! response to L-ascorbic acid
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071326 ! cellular response to monosaccharide stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound

[Term]
id: GO:0071299
name: cellular response to vitamin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:mah]
synonym: "cellular response to retinol" NARROW [GOC:mah]
is_a: GO:0033189 ! response to vitamin A
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071396 ! cellular response to lipid

[Term]
id: GO:0071300
name: cellular response to retinoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah]
synonym: "cellular response to vitamin A acid" EXACT [GOC:mah]
is_a: GO:0032526 ! response to retinoic acid
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071301
name: cellular response to vitamin B1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:mah]
synonym: "cellular response to thiamin" EXACT [GOC:mah]
synonym: "cellular response to thiamine" EXACT [GOC:mah]
is_a: GO:0010266 ! response to vitamin B1
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071302
name: cellular response to vitamin B2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah]
synonym: "cellular response to riboflavin" EXACT [GOC:mah]
is_a: GO:0033274 ! response to vitamin B2
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071303
name: cellular response to vitamin B3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:mah]
synonym: "cellular response to niacin" NARROW [GOC:mah]
synonym: "cellular response to nicotinamide" NARROW [GOC:mah]
is_a: GO:0033552 ! response to vitamin B3
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071304
name: cellular response to vitamin B6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah]
is_a: GO:0034516 ! response to vitamin B6
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071305
name: cellular response to vitamin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:mah]
synonym: "cellular response to calciferol" EXACT [GOC:mah]
synonym: "cellular response to cholecalciferol" NARROW [GOC:mah]
synonym: "cellular response to ergocalciferol" NARROW [GOC:mah]
is_a: GO:0033280 ! response to vitamin D
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071306
name: cellular response to vitamin E
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:mah]
synonym: "cellular response to DL-alpha-tocopherol acetate" NARROW [GOC:mah]
synonym: "cellular response to DL-alpha-tocopheryl acetate" NARROW [GOC:mah]
synonym: "cellular response to O-Acetyl-alpha-tocopherol" NARROW [GOC:mah]
is_a: GO:0033197 ! response to vitamin E
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071307
name: cellular response to vitamin K
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:mah]
is_a: GO:0032571 ! response to vitamin K
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071308
name: cellular response to menaquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:mah]
synonym: "cellular response to menatetrenone" EXACT [GOC:mah]
synonym: "cellular response to vitamin K2" EXACT [GOC:mah]
is_a: GO:0032572 ! response to menaquinone
is_a: GO:0071307 ! cellular response to vitamin K

[Term]
id: GO:0071309
name: cellular response to phylloquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah]
synonym: "cellular response to vitamin K1" EXACT [GOC:mah]
is_a: GO:0032573 ! response to phylloquinone
is_a: GO:0071307 ! cellular response to vitamin K

[Term]
id: GO:0071310
name: obsolete cellular response to organic substance
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0071311
name: cellular response to acetate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah]
is_a: GO:0010034 ! response to acetate
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071312
name: cellular response to alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah]
is_a: GO:0043279 ! response to alkaloid
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071313
name: cellular response to caffeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah]
is_a: GO:0031000 ! response to caffeine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071415 ! cellular response to purine-containing compound

[Term]
id: GO:0071314
name: cellular response to cocaine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah]
is_a: GO:0042220 ! response to cocaine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071315
name: cellular response to morphine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah]
is_a: GO:0043278 ! response to morphine
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid

[Term]
id: GO:0071316
name: cellular response to nicotine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah]
is_a: GO:0035094 ! response to nicotine
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071317
name: cellular response to isoquinoline alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:mah]
is_a: GO:0014072 ! response to isoquinoline alkaloid
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound

[Term]
id: GO:0071318
name: cellular response to ATP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah]
synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah]
synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah]
is_a: GO:0033198 ! response to ATP
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071319
name: cellular response to benzoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080021 ! response to benzoic acid
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071320
name: cellular response to cAMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah]
synonym: "cellular response to 3',5' cAMP" EXACT [GOC:mah]
synonym: "cellular response to 3',5'-cAMP" EXACT [GOC:mah]
synonym: "cellular response to adenosine 3',5'-cyclophosphate" EXACT [GOC:mah]
synonym: "cellular response to cyclic AMP" EXACT [GOC:mah]
is_a: GO:0051591 ! response to cAMP
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071321
name: cellular response to cGMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:mah]
synonym: "cellular response to 3',5' cGMP" EXACT [GOC:mah]
synonym: "cellular response to 3',5'-cGMP" EXACT [GOC:mah]
synonym: "cellular response to cyclic GMP" EXACT [GOC:mah]
synonym: "cellular response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah]
is_a: GO:0070305 ! response to cGMP
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071322
name: cellular response to carbohydrate stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah]
is_a: GO:0009743 ! response to carbohydrate
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071323
name: cellular response to chitin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah]
is_a: GO:0010200 ! response to chitin
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071324
name: cellular response to disaccharide stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:mah]
is_a: GO:0034285 ! response to disaccharide
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0071325
name: cellular response to mannitol stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." [GOC:mah]
is_a: GO:0010555 ! response to mannitol
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0071326
name: cellular response to monosaccharide stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah]
is_a: GO:0034284 ! response to monosaccharide
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0071327
name: cellular response to trehalose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [GOC:mah]
is_a: GO:0010353 ! response to trehalose
is_a: GO:0071324 ! cellular response to disaccharide stimulus

[Term]
id: GO:0071328
name: cellular response to maltose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:mah]
is_a: GO:0034286 ! response to maltose
is_a: GO:0071324 ! cellular response to disaccharide stimulus

[Term]
id: GO:0071329
name: cellular response to sucrose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah]
is_a: GO:0009744 ! response to sucrose
is_a: GO:0071324 ! cellular response to disaccharide stimulus

[Term]
id: GO:0071330
name: cellular response to trehalose-6-phosphate stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [GOC:mah]
is_a: GO:0071324 ! cellular response to disaccharide stimulus
is_a: GO:0080094 ! response to trehalose-6-phosphate

[Term]
id: GO:0071331
name: cellular response to hexose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah]
is_a: GO:0009746 ! response to hexose
is_a: GO:0071326 ! cellular response to monosaccharide stimulus

[Term]
id: GO:0071332
name: cellular response to fructose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah]
is_a: GO:0009750 ! response to fructose
is_a: GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0071333
name: cellular response to glucose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]
is_a: GO:0001678 ! intracellular glucose homeostasis
is_a: GO:0009749 ! response to glucose
is_a: GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0071334
name: cellular response to rhamnose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mah]
synonym: "cellular response to L-rhamnose stimulus" NARROW [GOC:mah]
is_a: GO:0032149 ! response to rhamnose
is_a: GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0071335
name: hair follicle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population." [GOC:rph, PMID:16086254]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0071336
name: regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle cell proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0071335 ! hair follicle cell proliferation

[Term]
id: GO:0071337
name: negative regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation." [GOC:mah]
synonym: "down regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of hair follicle cell proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0071336 ! regulation of hair follicle cell proliferation
relationship: negatively_regulates GO:0071335 ! hair follicle cell proliferation

[Term]
id: GO:0071338
name: positive regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hair follicle cell proliferation." [GOC:mah]
synonym: "activation of hair follicle cell proliferation" NARROW [GOC:mah]
synonym: "stimulation of hair follicle cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of hair follicle cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0071336 ! regulation of hair follicle cell proliferation
relationship: positively_regulates GO:0071335 ! hair follicle cell proliferation

[Term]
id: GO:0071339
name: MLL1 complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975]
is_a: GO:0044665 ! MLL1/2 complex

[Term]
id: GO:0071340
name: skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals." [GOC:bf, GOC:dsf, PMID:19285469]
synonym: "skeletal muscle AChR clustering" EXACT [GOC:mah]
synonym: "skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:bf]
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization
relationship: part_of GO:0007528 ! neuromuscular junction development

[Term]
id: GO:0071341
name: medial cortical node
namespace: cellular_component
def: "A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis." [GOC:mah, GOC:vw, PMID:19474789, PMID:19959363]
synonym: "mid1p medial cortical dot" EXACT [GOC:vw]
synonym: "midsome" EXACT [GOC:vw, PMID:19959363]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031097 ! medial cortex

[Term]
id: GO:0071342
name: obsolete regulation of establishment of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
is_obsolete: true
replaced_by: GO:2000073

[Term]
id: GO:0071343
name: obsolete negative regulation of establishment of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location." [GOC:mah]
comment: This term was made obsolete because it does not describe a wild-type or normal process.
synonym: "negative regulation of establishment of actomyosin contractile ring localization" EXACT []
synonym: "negative regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "negative regulation of establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "negative regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0071344
name: diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid." [GOC:pde]
synonym: "pyrophosphate metabolism" EXACT [GOC:mah]
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0071345
name: cellular response to cytokine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0071346
name: cellular response to type II interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah]
synonym: "cellular response to gamma-interferon" RELATED [GOC:mah]
synonym: "cellular response to immune interferon" EXACT [GOC:mah]
synonym: "cellular response to interferon-gamma" BROAD [GOC:mah]
synonym: "cellular response to type II IFN" BROAD [GOC:mah]
is_a: GO:0034341 ! response to type II interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071347
name: cellular response to interleukin-1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:mah]
synonym: "cellular response to IL-1" EXACT [GOC:mah]
is_a: GO:0070555 ! response to interleukin-1
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071348
name: cellular response to interleukin-11
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah]
synonym: "cellular response to IL-11" EXACT [GOC:mah]
is_a: GO:0071105 ! response to interleukin-11
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071349
name: cellular response to interleukin-12
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah]
synonym: "cellular response to IL-12" EXACT [GOC:mah]
is_a: GO:0070671 ! response to interleukin-12
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071350
name: cellular response to interleukin-15
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah]
synonym: "cellular response to IL-15" EXACT [GOC:mah]
is_a: GO:0070672 ! response to interleukin-15
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071351
name: cellular response to interleukin-18
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah]
synonym: "cellular response to IL-18" EXACT [GOC:mah]
is_a: GO:0070673 ! response to interleukin-18
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071352
name: cellular response to interleukin-2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah]
synonym: "cellular response to IL-2" EXACT [GOC:mah]
is_a: GO:0070669 ! response to interleukin-2
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071353
name: cellular response to interleukin-4
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]
synonym: "cellular response to IL-4" EXACT [GOC:mah]
is_a: GO:0070670 ! response to interleukin-4
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071354
name: cellular response to interleukin-6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]
synonym: "cellular response to IL-6" EXACT [GOC:mah]
is_a: GO:0070741 ! response to interleukin-6
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071355
name: cellular response to interleukin-9
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah]
synonym: "cellular response to IL-9" EXACT [GOC:mah]
is_a: GO:0071104 ! response to interleukin-9
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071356
name: cellular response to tumor necrosis factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]
synonym: "cellular response to TNF" EXACT [GOC:mah]
is_a: GO:0034612 ! response to tumor necrosis factor
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071357
name: cellular response to type I interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah]
synonym: "cellular response to type I IFN" EXACT [GOC:mah]
is_a: GO:0034340 ! response to type I interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071358
name: cellular response to type III interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:mah]
synonym: "cellular response to interferon-lambda" NARROW [GOC:mah]
synonym: "cellular response to type III IFN" EXACT [GOC:mah]
is_a: GO:0034342 ! response to type III interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071359
name: cellular response to dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:mah]
synonym: "cellular response to double-stranded RNA" EXACT [GOC:mah]
is_a: GO:0043331 ! response to dsRNA
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071360
name: cellular response to exogenous dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:mah]
synonym: "cellular response to exogenous double-stranded RNA" EXACT [GOC:mah]
synonym: "cellular response to viral dsRNA" NARROW [GOC:mah]
is_a: GO:0043330 ! response to exogenous dsRNA
is_a: GO:0071359 ! cellular response to dsRNA

[Term]
id: GO:0071361
name: cellular response to ethanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah]
is_a: GO:0045471 ! response to ethanol
is_a: GO:0097306 ! cellular response to alcohol

[Term]
id: GO:0071362
name: cellular response to ether
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:mah]
is_a: GO:0045472 ! response to ether
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071363
name: cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]
is_a: GO:0070848 ! response to growth factor
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0071364
name: cellular response to epidermal growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]
synonym: "cellular response to EGF stimulus" EXACT [GOC:mah]
is_a: GO:0070849 ! response to epidermal growth factor
is_a: GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0071365
name: cellular response to auxin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:mah]
is_a: GO:0009733 ! response to auxin
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071366
name: cellular response to indolebutyric acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah]
synonym: "cellular response to IBA stimulus" EXACT [GOC:mah]
synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah]
is_a: GO:0071365 ! cellular response to auxin stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080026 ! response to indolebutyric acid
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071367
name: cellular response to brassinosteroid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:mah]
is_a: GO:0009741 ! response to brassinosteroid
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071368
name: cellular response to cytokinin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:mah]
is_a: GO:0009735 ! response to cytokinin
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071369
name: cellular response to ethylene stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:mah]
synonym: "cellular response to ethene stimulus" EXACT [GOC:mah]
is_a: GO:0009723 ! response to ethylene
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071370
name: cellular response to gibberellin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:mah]
synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah]
is_a: GO:0009739 ! response to gibberellin
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071371
name: cellular response to gonadotropin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:mah]
synonym: "cellular response to gonadotrophin stimulus" EXACT [GOC:dph]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0034698 ! response to gonadotropin

[Term]
id: GO:0071372
name: cellular response to follicle-stimulating hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah]
synonym: "cellular response to follicle stimulating hormone stimulus" EXACT []
synonym: "cellular response to FSH stimulus" EXACT []
is_a: GO:0032354 ! response to follicle-stimulating hormone
is_a: GO:0071371 ! cellular response to gonadotropin stimulus

[Term]
id: GO:0071373
name: cellular response to luteinizing hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:mah]
is_a: GO:0034699 ! response to luteinizing hormone
is_a: GO:0071371 ! cellular response to gonadotropin stimulus
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0071374
name: cellular response to parathyroid hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071107 ! response to parathyroid hormone

[Term]
id: GO:0071375
name: cellular response to peptide hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]
synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0043434 ! response to peptide hormone
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071376
name: cellular response to corticotropin-releasing hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [GOC:mah]
synonym: "cellular response to corticoliberin stimulus" EXACT [GOC:mah]
synonym: "cellular response to corticotropin-releasing factor stimulus" EXACT [GOC:mah]
synonym: "cellular response to CRF stimulus" EXACT [GOC:mah]
synonym: "cellular response to CRH stimulus" EXACT [GOC:mah]
is_a: GO:0043435 ! response to corticotropin-releasing hormone
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0071377
name: cellular response to glucagon stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah]
is_a: GO:0033762 ! response to glucagon
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0071378
name: cellular response to growth hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:mah]
is_a: GO:0060416 ! response to growth hormone
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0071379
name: cellular response to prostaglandin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0034694 ! response to prostaglandin
is_a: GO:0071396 ! cellular response to lipid

[Term]
id: GO:0071380
name: cellular response to prostaglandin E stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:mah]
is_a: GO:0034695 ! response to prostaglandin E
is_a: GO:0071379 ! cellular response to prostaglandin stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071381
name: cellular response to prostaglandin F stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:mah]
is_a: GO:0034696 ! response to prostaglandin F
is_a: GO:0071379 ! cellular response to prostaglandin stimulus

[Term]
id: GO:0071382
name: cellular response to prostaglandin I stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:mah]
is_a: GO:0034697 ! response to prostaglandin I
is_a: GO:0071379 ! cellular response to prostaglandin stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071383
name: cellular response to steroid hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0048545 ! response to steroid hormone
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound

[Term]
id: GO:0071384
name: cellular response to corticosteroid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah]
is_a: GO:0031960 ! response to corticosteroid
is_a: GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0071385
name: cellular response to glucocorticoid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:mah]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0071384 ! cellular response to corticosteroid stimulus

[Term]
id: GO:0071386
name: cellular response to corticosterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [GOC:mah]
is_a: GO:0051412 ! response to corticosterone
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071387
name: cellular response to cortisol stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah]
synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah]
is_a: GO:0051414 ! response to cortisol
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071388
name: cellular response to cortisone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [GOC:mah]
is_a: GO:0051413 ! response to cortisone
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071389
name: cellular response to mineralocorticoid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:mah]
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0071384 ! cellular response to corticosteroid stimulus

[Term]
id: GO:0071390
name: cellular response to ecdysone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
is_a: GO:0035075 ! response to ecdysone
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071391
name: cellular response to estrogen stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah]
synonym: "cellular response to 17alpha-ethynylestradiol" RELATED []
synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0043627 ! response to estrogen

[Term]
id: GO:0071392
name: cellular response to estradiol stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah]
synonym: "cellular response to E2 stimulus" EXACT [GOC:mah]
is_a: GO:0032355 ! response to estradiol
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071393
name: cellular response to progesterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah]
is_a: GO:0032570 ! response to progesterone
is_a: GO:0071383 ! cellular response to steroid hormone stimulus
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071394
name: cellular response to testosterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah]
is_a: GO:0033574 ! response to testosterone
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071395
name: cellular response to jasmonic acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah]
is_a: GO:0009753 ! response to jasmonic acid
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071398 ! cellular response to fatty acid

[Term]
id: GO:0071396
name: cellular response to lipid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]
is_a: GO:0033993 ! response to lipid
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071397
name: cellular response to cholesterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:mah]
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:0070723 ! response to cholesterol
is_a: GO:0097306 ! cellular response to alcohol

[Term]
id: GO:0071398
name: cellular response to fatty acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah]
is_a: GO:0070542 ! response to fatty acid
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071399
name: cellular response to linoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:mah]
synonym: "cellular response to linoleate" EXACT [GOC:mah]
is_a: GO:0070543 ! response to linoleic acid
is_a: GO:0071398 ! cellular response to fatty acid

[Term]
id: GO:0071400
name: cellular response to oleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:mah]
synonym: "cellular response to oleate" EXACT [GOC:mah]
is_a: GO:0034201 ! response to oleic acid
is_a: GO:0071398 ! cellular response to fatty acid

[Term]
id: GO:0071401
name: cellular response to triglyceride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:mah]
synonym: "cellular response to triacylglyceride" EXACT [GOC:mah]
synonym: "cellular response to triacylglycerol" EXACT [GOC:mah]
is_a: GO:0034014 ! response to triglyceride
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071402
name: cellular response to lipoprotein particle stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:mah]
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0071403
name: cellular response to high density lipoprotein particle stimulus
namespace: biological_process
alt_id: GO:0055099
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus." [GOC:mah]
synonym: "cellular response to high-density lipoprotein particle stimulus" EXACT []
synonym: "response to high density lipoprotein particle" BROAD []
synonym: "response to high density lipoprotein particle stimulus" BROAD [GOC:dos]
is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus

[Term]
id: GO:0071404
name: cellular response to low-density lipoprotein particle stimulus
namespace: biological_process
alt_id: GO:0055098
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus." [GOC:mah]
synonym: "response to low density lipoprotein particle" BROAD []
synonym: "response to low-density lipoprotein particle" BROAD [GOC:dos]
synonym: "response to low-density lipoprotein particle stimulus" BROAD []
is_a: GO:0055094 ! response to lipoprotein particle
is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus

[Term]
id: GO:0071405
name: cellular response to methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah]
is_a: GO:0033986 ! response to methanol
is_a: GO:0097306 ! cellular response to alcohol

[Term]
id: GO:0071406
name: cellular response to methylmercury
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:mah]
synonym: "cellular response to CH3-Hg+" EXACT [GOC:mah]
synonym: "cellular response to MeHg+" EXACT [GOC:mah]
is_a: GO:0051597 ! response to methylmercury

[Term]
id: GO:0071407
name: cellular response to organic cyclic compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]
synonym: "cellular response to organic cyclic substance" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071408
name: cellular response to cycloalkane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:mah]
is_a: GO:0014071 ! response to cycloalkane
is_a: GO:0071407 ! cellular response to organic cyclic compound

[Term]
id: GO:0071409
name: cellular response to cycloheximide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah]
synonym: "cellular response to actidione" EXACT [GOC:mah]
is_a: GO:0046898 ! response to cycloheximide
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071410
name: cellular response to cyclopentenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [GOC:mah]
is_a: GO:0010583 ! response to cyclopentenone
is_a: GO:0071407 ! cellular response to organic cyclic compound

[Term]
id: GO:0071411
name: cellular response to fluoxetine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:mah, GOC:pr]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014076 ! response to fluoxetine
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071412
name: cellular response to genistein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah]
is_a: GO:0033595 ! response to genistein
is_a: GO:0071413 ! cellular response to hydroxyisoflavone

[Term]
id: GO:0071413
name: cellular response to hydroxyisoflavone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah]
is_a: GO:0033594 ! response to hydroxyisoflavone
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1905546 ! cellular response to phenylpropanoid

[Term]
id: GO:0071414
name: cellular response to methotrexate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah]
is_a: GO:0031427 ! response to methotrexate
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071415
name: cellular response to purine-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:mah]
synonym: "cellular response to purine" RELATED []
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071416
name: cellular response to tropane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:mah]
is_a: GO:0014073 ! response to tropane
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound

[Term]
id: GO:0071417
name: obsolete cellular response to organonitrogen compound
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "cellular response to organic nitrogen" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071418
name: cellular response to amine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah]
is_a: GO:0014075 ! response to amine
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071419
name: cellular response to amphetamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah]
is_a: GO:0001975 ! response to amphetamine
is_a: GO:0071418 ! cellular response to amine stimulus

[Term]
id: GO:0071420
name: cellular response to histamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:mah]
synonym: "cellular response to histamine stimulus" EXACT [GOC:mah]
is_a: GO:0034776 ! response to histamine
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071421
name: manganese ion transmembrane transport
namespace: biological_process
def: "A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "manganese ion membrane transport" EXACT []
synonym: "transmembrane manganese transport" EXACT [GOC:mah]
is_a: GO:0006828 ! manganese ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0071422
name: succinate transmembrane transport
namespace: biological_process
def: "The process in which succinate is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "succinate membrane transport" EXACT []
synonym: "transmembrane succinate transport" EXACT [GOC:mah]
is_a: GO:0015744 ! succinate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0071423
name: malate transmembrane transport
namespace: biological_process
def: "A process in which a malate ion is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "malate membrane transport" EXACT []
synonym: "transmembrane malate transport" EXACT [GOC:mah]
is_a: GO:0015743 ! malate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0071424
name: rRNA (cytosine-N4-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine." [GOC:imk, PMID:19965768, RHEA:62520]
xref: RHEA:62520
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity

[Term]
id: GO:0071425
name: hematopoietic stem cell proliferation
namespace: biological_process
def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]
synonym: "hemopoietic stem cell proliferation" EXACT []
is_a: GO:0072089 ! stem cell proliferation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0071426
name: obsolete ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm." [GOC:mah]
comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate.
synonym: "ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "RNP export from nucleus" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071427
name: obsolete mRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm." [GOC:mah]
comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate.
synonym: "mRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "mRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006406

[Term]
id: GO:0071428
name: obsolete rRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm." [GOC:mah]
comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate.
synonym: "rRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "rRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071429
name: obsolete snRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm." [GOC:mah]
comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate.
synonym: "snRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "snRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071430
name: obsolete pre-miRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm." [GOC:mah, GOC:sl]
comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate.
synonym: "pre-microRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "pre-microRNA-containing ribonucleoprotein complex export from nucleus" EXACT []
synonym: "pre-microRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "pre-microRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071431
name: obsolete tRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm." [GOC:mah]
comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate.
synonym: "tRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "tRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0051168

[Term]
id: GO:0071432
name: peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion
namespace: biological_process
def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "a-factor processing (proteolytic)" NARROW [GOC:vw]
synonym: "alpha-factor maturation" NARROW [GOC:vw]
synonym: "mating-type peptide pheromone maturation involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "peptide mating pheromone formation involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "peptide mating pheromone processing involved in conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0007323 ! peptide pheromone maturation
relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0071433
name: cell wall repair
namespace: biological_process
def: "A process of cell wall organization that results in the restoration of the cell wall following damage." [GOC:mah, GOC:vw]
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0071434
name: cell chemotaxis to angiotensin
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of angiotensin." [GOC:mah]
synonym: "angiotensin mediated chemotaxis" BROAD [GOC:mah]
synonym: "angiotensin-mediated cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0071437
name: obsolete invadopodium
namespace: cellular_component
def: "OBSOLETE. A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate." [GOC:mah, PMID:16651416, PMID:19491051, PMID:19931459]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
is_obsolete: true

[Term]
id: GO:0071438
name: obsolete invadopodium membrane
namespace: cellular_component
def: "OBSOLETE. The portion of the plasma membrane surrounding an invadopodium." [GOC:mah]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
is_obsolete: true

[Term]
id: GO:0071439
name: clathrin complex
namespace: cellular_component
def: "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411]
synonym: "clathrin triskelion" EXACT [GOC:mah]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030118 ! clathrin coat

[Term]
id: GO:0071440
name: obsolete regulation of histone H3-K14 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "regulation of histone H3K14 acetylation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:0071441
name: obsolete negative regulation of histone H3-K14 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "down-regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "downregulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "inhibition of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "negative regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "negative regulation of histone H3K14 acetylation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:0071442
name: obsolete positive regulation of histone H3-K14 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "positive regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "positive regulation of histone H3K14 acetylation" EXACT [GOC:mah]
synonym: "stimulation of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "up regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "up-regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "upregulation of histone H3-K14 acetylation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:0071443
name: tDNA binding
namespace: molecular_function
def: "Binding to DNA sequences encoding transfer RNA." [GOC:mah]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0071444
name: cellular response to pheromone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:mah]
synonym: "cellular pheromone response" EXACT [GOC:mah]
is_a: GO:0019236 ! response to pheromone
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071445
name: obsolete cellular response to protein stimulus
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:mah]
comment: This term was made obsolete because more specific terms exist.
synonym: "cellular response to protein stimulus" EXACT []
is_obsolete: true
consider: GO:0032870
consider: GO:0034620
consider: GO:0071218
consider: GO:0071345
consider: GO:0071363

[Term]
id: GO:0071446
name: cellular response to salicylic acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah]
synonym: "cellular response to salicylate stimulus" EXACT [GOC:dph]
is_a: GO:0009751 ! response to salicylic acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071447
name: cellular response to hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah]
is_a: GO:0033194 ! response to hydroperoxide
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071448
name: cellular response to alkyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah]
is_a: GO:0033195 ! response to alkyl hydroperoxide
is_a: GO:0071447 ! cellular response to hydroperoxide

[Term]
id: GO:0071449
name: cellular response to lipid hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:mah]
synonym: "cellular response to LHPO" EXACT [GOC:mah]
is_a: GO:0006982 ! response to lipid hydroperoxide
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071447 ! cellular response to hydroperoxide

[Term]
id: GO:0071450
name: cellular response to oxygen radical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah]
is_a: GO:0000305 ! response to oxygen radical
is_a: GO:0034614 ! cellular response to reactive oxygen species

[Term]
id: GO:0071451
name: cellular response to superoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah]
is_a: GO:0000303 ! response to superoxide
is_a: GO:0071450 ! cellular response to oxygen radical

[Term]
id: GO:0071452
name: cellular response to singlet oxygen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah]
is_a: GO:0000304 ! response to singlet oxygen
is_a: GO:0034614 ! cellular response to reactive oxygen species

[Term]
id: GO:0071453
name: cellular response to oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah]
synonym: "cellular response to oxygen" RELATED [GOC:al]
is_a: GO:0070482 ! response to oxygen levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071454
name: cellular response to anoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah]
comment: Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'.
synonym: "cellular response to anaerobic conditions" EXACT [GOC:elh]
synonym: "cellular response to anoxic stress" EXACT [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034059 ! response to anoxia
is_a: GO:0036294 ! cellular response to decreased oxygen levels

[Term]
id: GO:0071455
name: cellular response to hyperoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:mah]
synonym: "cellular response to hyperoxic stress" EXACT [GOC:mah]
synonym: "cellular response to increased oxygen tension" EXACT [GOC:mah]
is_a: GO:0036295 ! cellular response to increased oxygen levels
is_a: GO:0055093 ! response to hyperoxia
is_a: GO:0062197 ! cellular response to chemical stress

[Term]
id: GO:0071456
name: cellular response to hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
comment: Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "cellular response to hypoxic stress" EXACT [GOC:mah]
synonym: "cellular response to lowered oxygen tension" EXACT [GOC:mah]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0036294 ! cellular response to decreased oxygen levels

[Term]
id: GO:0071457
name: cellular response to ozone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah]
is_a: GO:0010193 ! response to ozone
is_a: GO:0034614 ! cellular response to reactive oxygen species

[Term]
id: GO:0071458
name: obsolete integral component of cytoplasmic side of endoplasmic reticulum membrane
namespace: cellular_component
def: "OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to cytosolic leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab]
synonym: "integral to cytosolic side of endoplasmic reticulum membrane" EXACT []
synonym: "integral to cytosolic side of ER membrane" EXACT [GOC:mah]
synonym: "integral to ER membrane, cytosolic side" EXACT [GOC:vw]
is_obsolete: true
replaced_by: GO:0098554

[Term]
id: GO:0071459
name: protein localization to chromosome, centromeric region
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome." [GOC:mah]
synonym: "protein localisation to chromosome, centromeric region" EXACT [GOC:mah]
synonym: "protein localization to centromere" EXACT [GOC:mah]
synonym: "protein localization to chromosome, centric region" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0071460
name: cellular response to cell-matrix adhesion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion." [GOC:sl, PMID:11425869]
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0071461
name: cellular response to redox state
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah]
synonym: "cellular redox signal response" EXACT [GOC:mah]
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0071462
name: cellular response to water stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah]
is_a: GO:0009415 ! response to water
is_a: GO:0071214 ! cellular response to abiotic stimulus
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071463
name: cellular response to humidity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:mah]
is_a: GO:0009270 ! response to humidity
is_a: GO:0071462 ! cellular response to water stimulus

[Term]
id: GO:0071464
name: cellular response to hydrostatic pressure
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:mah]
synonym: "cellular response to biomechanical stress" BROAD [GOC:mah]
synonym: "cellular response to static fluid pressure" EXACT [GOC:mah]
is_a: GO:0051599 ! response to hydrostatic pressure
is_a: GO:0062197 ! cellular response to chemical stress
is_a: GO:0071462 ! cellular response to water stimulus

[Term]
id: GO:0071465
name: cellular response to desiccation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:mah]
synonym: "desiccation tolerance" RELATED [GOC:mah]
is_a: GO:0009269 ! response to desiccation
is_a: GO:0042631 ! cellular response to water deprivation

[Term]
id: GO:0071466
name: cellular response to xenobiotic stimulus
namespace: biological_process
alt_id: GO:0035690
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:krc, GOC:mah]
subset: goslim_chembl
synonym: "cellular response to drug" RELATED []
is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071467
name: cellular response to pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:mah, Wikipedia:PH]
is_a: GO:0009268 ! response to pH
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071468
name: cellular response to acidic pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, Wikipedia:PH]
comment: This term should be used to annotate instances where a cell is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0071229 'cellular response to acid chemical'.
synonym: "cellular response to acidity" BROAD []
is_a: GO:0010447 ! response to acidic pH
is_a: GO:0071467 ! cellular response to pH

[Term]
id: GO:0071469
name: cellular response to alkaline pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, Wikipedia:PH]
synonym: "cellular response to alkalinity" BROAD []
synonym: "cellular response to basic pH" EXACT [GOC:mah]
is_a: GO:0010446 ! response to alkaline pH
is_a: GO:0071467 ! cellular response to pH

[Term]
id: GO:0071470
name: cellular response to osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "cellular osmotic response" EXACT [GOC:mah]
synonym: "cellular osmotic stress response" EXACT [GOC:mah]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0062197 ! cellular response to chemical stress
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071471
name: cellular response to non-ionic osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:mah]
is_a: GO:0010335 ! response to non-ionic osmotic stress
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071472
name: cellular response to salt stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
synonym: "cellular response to ionic osmotic stress" EXACT [GOC:mah]
synonym: "cellular salinity response" EXACT [GOC:mah]
is_a: GO:0009651 ! response to salt stress
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071473
name: cellular response to cation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:mah]
is_a: GO:0043157 ! response to cation stress
is_a: GO:0071472 ! cellular response to salt stress

[Term]
id: GO:0071474
name: cellular hyperosmotic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:mah]
synonym: "cellular HOG response" EXACT [GOC:mah]
synonym: "cellular hypertonic response" EXACT [GOC:mah]
synonym: "cellular response to hypertonicity" EXACT [GOC:mah, GOC:yaf]
is_a: GO:0006972 ! hyperosmotic response
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071475
name: cellular hyperosmotic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
synonym: "cellular response to hyperosmotic salt stress" EXACT [GOC:mah]
is_a: GO:0042538 ! hyperosmotic salinity response
is_a: GO:0071472 ! cellular response to salt stress
is_a: GO:0071474 ! cellular hyperosmotic response

[Term]
id: GO:0071476
name: cellular hypotonic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:mah]
synonym: "cellular hypo-osmotic response" EXACT [GOC:mah]
is_a: GO:0006971 ! hypotonic response
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071477
name: cellular hypotonic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
synonym: "cellular response to hypotonic salt stress" EXACT [GOC:mah]
is_a: GO:0042539 ! hypotonic salinity response
is_a: GO:0071472 ! cellular response to salt stress
is_a: GO:0071476 ! cellular hypotonic response

[Term]
id: GO:0071478
name: cellular response to radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to radiation stimulus" EXACT [GOC:mah]
is_a: GO:0009314 ! response to radiation
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071479
name: cellular response to ionizing radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]
synonym: "cellular response to ionising radiation" EXACT [GOC:mah]
synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010212 ! response to ionizing radiation
is_a: GO:0071478 ! cellular response to radiation

[Term]
id: GO:0071480
name: cellular response to gamma radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
synonym: "cellular response to gamma ray" RELATED [GOC:mah]
synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah]
is_a: GO:0010332 ! response to gamma radiation
is_a: GO:0071479 ! cellular response to ionizing radiation

[Term]
id: GO:0071481
name: cellular response to X-ray
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah]
synonym: "cellular response to X-ray radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010165 ! response to X-ray
is_a: GO:0071479 ! cellular response to ionizing radiation

[Term]
id: GO:0071482
name: cellular response to light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0071478 ! cellular response to radiation

[Term]
id: GO:0071483
name: cellular response to blue light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:mah]
synonym: "cellular response to blue light stimulus" EXACT [GOC:mah]
is_a: GO:0009637 ! response to blue light
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0071484
name: cellular response to light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:mah]
is_a: GO:0009642 ! response to light intensity
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0071485
name: cellular response to absence of light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:mah]
synonym: "cellular response to darkness" RELATED []
is_a: GO:0009646 ! response to absence of light
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071486
name: cellular response to high light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:mah]
is_a: GO:0009644 ! response to high light intensity
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071487
name: cellular response to low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:mah]
is_a: GO:0009645 ! response to low light intensity stimulus
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071488
name: cellular response to very low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mah]
is_a: GO:0055122 ! response to very low light intensity stimulus
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071489
name: cellular response to red or far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
is_a: GO:0009639 ! response to red or far red light
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0071490
name: cellular response to far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
synonym: "cellular response to far red light stimulus" EXACT [GOC:mah]
is_a: GO:0010218 ! response to far red light
is_a: GO:0071489 ! cellular response to red or far red light

[Term]
id: GO:0071491
name: cellular response to red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
synonym: "cellular response to red light stimulus" EXACT [GOC:mah]
is_a: GO:0010114 ! response to red light
is_a: GO:0071489 ! cellular response to red or far red light

[Term]
id: GO:0071492
name: cellular response to UV-A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:mah]
synonym: "cellular response to UV-A light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-A radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVA light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVA radiation stimulus" EXACT [GOC:mah]
is_a: GO:0034644 ! cellular response to UV
is_a: GO:0070141 ! response to UV-A

[Term]
id: GO:0071493
name: cellular response to UV-B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:mah]
synonym: "cellular response to medium wave ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to medium wave ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-B light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-B radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVB light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVB radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010224 ! response to UV-B
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0071494
name: cellular response to UV-C
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:mah]
synonym: "cellular response to germicidal ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to germicidal ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to shortwave ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to shortwave ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-C light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-C radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVC light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVC radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010225 ! response to UV-C
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0071495
name: cellular response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0009719 ! response to endogenous stimulus

[Term]
id: GO:0071496
name: cellular response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0071497
name: cellular response to freezing
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:mah]
synonym: "antifreeze activity" RELATED [GOC:mah]
synonym: "ice nucleation inhibitor activity" RELATED [GOC:mah]
is_a: GO:0050826 ! response to freezing
is_a: GO:0070417 ! cellular response to cold

[Term]
id: GO:0071498
name: cellular response to fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034405 ! response to fluid shear stress

[Term]
id: GO:0071499
name: cellular response to laminar fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers." [GOC:mah]
is_a: GO:0034616 ! response to laminar fluid shear stress
is_a: GO:0071498 ! cellular response to fluid shear stress

[Term]
id: GO:0071500
name: cellular response to nitrosative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:mah]
is_a: GO:0051409 ! response to nitrosative stress
is_a: GO:0062197 ! cellular response to chemical stress

[Term]
id: GO:0071501
name: cellular response to sterol depletion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:mah]
synonym: "cellular sterol depletion response" EXACT [GOC:mah]
is_a: GO:0006991 ! response to sterol depletion
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0071502
name: cellular response to temperature stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:mah]
synonym: "cellular response to thermal stimulus" EXACT [GOC:mah]
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0071503
name: response to heparin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0071504
name: cellular response to heparin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0071503 ! response to heparin
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071505
name: response to mycophenolic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf]
synonym: "response to mycophenolate" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0071506
name: cellular response to mycophenolic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf]
synonym: "cellular response to mycophenolate" EXACT [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071505 ! response to mycophenolic acid
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071507
name: pheromone response MAPK cascade
namespace: biological_process
def: "A MAPK cascade containing at least the Fus3 MAP kinase. It starts with the activation of Ste20, a MAP4K, which activates Ste11, a MAP3K, which in turn activate Ste7, a MAP2K, which activates Fus3. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. This MAPK cascade is triggered by a pheromone activating its G protein-coupled receptor, and results in cellular responses that lead to conjugation with cellular fusion." [GOC:mah, GOC:vw, PMID:17604854]
synonym: "conjugation with cellular fusion, MAPKKK cascade" EXACT [GOC:mah]
synonym: "Fus3 signaling cascade" NARROW [PMID:20880736]
synonym: "MAPK cascade involved in conjugation with cellular fusion" EXACT []
synonym: "MAPK signaling in response to pheromone" RELATED [PMID:20880736]
synonym: "MAPKKK cascade involved in conjugation with cellular fusion" EXACT [GOC:signaling]
synonym: "MAPKKK cascade involved in mating response" RELATED [GOC:mah]
synonym: "pheromone MAPK module" RELATED [PMID:20880736]
is_a: GO:0000165 ! MAPK cascade
relationship: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0071508
name: obsolete activation of MAPK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of MAPK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPK activity" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071509
name: obsolete activation of MAPKK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of conjugation with cellular fusion." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of MAP kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "activation of MAPKK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAP kinase kinase activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPKK activity" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071510
name: obsolete activation of MAPKKK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of conjugation with cellular fusion." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of MAP kinase kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "activation of MAPKKK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAP kinase kinase kinase activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPKKK activity" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071511
name: obsolete inactivation of MAPK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "conjugation with cellular fusion, inactivation of MAPK activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, termination of MAPK activity" EXACT [GOC:mah]
synonym: "inactivation of MAPK activity involved in mating response" RELATED [GOC:mah]
synonym: "termination of MAPK activity during conjugation with cellular fusion" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071512
name: obsolete MAPK import into nucleus involved in conjugation with cellular fusion
namespace: biological_process
def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of conjugation with cellular fusion." [GOC:mah]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "conjugation with cellular fusion, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, nuclear translocation of MAPK" NARROW [GOC:mah]
synonym: "MAPK import into nucleus involved in mating response" RELATED [GOC:mah]
synonym: "nuclear translocation of MAPK involved in conjugation with cellular fusion" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in mating response" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:0071513
name: phosphopantothenoylcysteine decarboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces." [GOC:jh, PMID:19915539]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0071514
name: genomic imprinting
namespace: biological_process
def: "The establishment of epigenetic modifications (imprints) during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation." [PMID:24492710, PMID:31896690, PMID:31965998]
synonym: "DNA imprinting" EXACT [GOC:mah]
synonym: "establishment of genomic imprinting" EXACT []
synonym: "genetic imprinting" EXACT []
is_a: GO:0043045 ! epigenetic programming of gene expression
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0071515
name: mating-type locus imprinting
namespace: biological_process
def: "A genomic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894]
synonym: "genetic imprinting at mating-type locus" EXACT []
synonym: "genomic imprinting at mating-type locus" EXACT []
synonym: "mating type determination, imprinting" EXACT [GOC:vw]
is_a: GO:0022413 ! reproductive process in single-celled organism
relationship: part_of GO:0007533 ! mating type switching

[Term]
id: GO:0071516
name: obsolete establishment of imprinting at mating-type locus
namespace: biological_process
def: "OBSOLETE. The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:18723894]
comment: This term was obsoleted because it represents a molecular function.
synonym: "mating type determination, establishment of imprinting" EXACT [GOC:vw]
is_obsolete: true
replaced_by: GO:0071515

[Term]
id: GO:0071517
name: obsolete maintenance of imprinting at mating-type locus
namespace: biological_process
def: "OBSOLETE. Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894]
comment: Tis term was obsoleted because it represents a molecular function.
synonym: "mating type determination, maintenance of imprinting" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0071515

[Term]
id: GO:0071518
name: autoinducer-2 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244]
synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:29484, GOC:mah]
xref: MetaCyc:RXN0-5461
xref: RHEA:15377
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0071519
name: actomyosin contractile ring actin filament bundle assembly
namespace: biological_process
def: "A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis." [GOC:mah, PMID:19713940]
synonym: "actin filament bundle assembly involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb]
synonym: "actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly" EXACT []
is_a: GO:0051017 ! actin filament bundle assembly
is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization

[Term]
id: GO:0071520
name: actomyosin contractile ring assembly actin filament bundle convergence
namespace: biological_process
def: "A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring." [GOC:mah, PMID:19713940]
synonym: "actin filament bundle convergence involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb]
synonym: "actin filament bundle convergence involved in cytokinetic actomyosin contractile ring assembly" EXACT []
is_a: GO:0090426 ! actin filament bundle convergence
is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization

[Term]
id: GO:0071521
name: Cdc42 GTPase complex
namespace: cellular_component
def: "A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signaling pathway." [GOC:mah, GOC:vw, PMID:10567532, PMID:7923372, PMID:8943016]
synonym: "Ras1-Scd1-Scd2-Cdc42-Shk1 complex" EXACT [GOC:vw]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1905360 ! GTPase complex

[Term]
id: GO:0071522
name: ureidoglycine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185]
xref: EC:3.5.3.26
xref: MetaCyc:URUR-RXN
xref: RHEA:25241
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0071523
name: obsolete TIR domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TIR domain interaction." [GOC:amm]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
is_obsolete: true

[Term]
id: GO:0071524
name: pyrrolysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [GOC:dh, PMID:17204561]
synonym: "monomethylamine methyltransferase cofactor lysine adduct biosynthetic process" EXACT [CHEBI:21860]
synonym: "pyrrolysine anabolism" EXACT [GOC:mah]
synonym: "pyrrolysine biosynthesis" EXACT [GOC:mah]
synonym: "pyrrolysine formation" EXACT [GOC:mah]
synonym: "pyrrolysine synthesis" EXACT [GOC:mah]
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0071525 ! pyrrolysine metabolic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process

[Term]
id: GO:0071525
name: pyrrolysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [GOC:mah, PMID:17204561]
synonym: "monomethylamine methyltransferase cofactor lysine adduct metabolic process" EXACT [CHEBI:21860]
synonym: "pyrrolysine metabolism" EXACT [GOC:mah]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0071526
name: semaphorin-plexin signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]
synonym: "semaphorin-plexin signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0071527
name: semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]
synonym: "semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:mah]
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0071528
name: tRNA re-export from nucleus
namespace: biological_process
def: "The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305]
synonym: "tRNA reexport from nucleus" EXACT [GOC:mcc]
is_a: GO:0006409 ! tRNA export from nucleus

[Term]
id: GO:0071529
name: cementum mineralization
namespace: biological_process
def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum." [GOC:sl, PMID:17043865]
synonym: "cementum formation" RELATED [GOC:mah]
is_a: GO:0034505 ! tooth mineralization

[Term]
id: GO:0071530
name: obsolete FHA domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR000253]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "forkhead-associated domain-mediated complex assembly" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071531
name: obsolete Rel homology domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a Rel homology domain (RHD) interaction." [GOC:amm, InterPro:IPR011539]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "RHD domain-mediated complex assembly" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071532
name: ankyrin repeat binding
namespace: molecular_function
def: "Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110]
synonym: "ANK repeat binding" EXACT [GOC:amm]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071533
name: obsolete ankyrin repeat-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an ankyrin repeat interaction." [GOC:amm, InterPro:IPR002110]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "ANK repeat-mediated complex assembly" EXACT [GOC:amm]
is_obsolete: true

[Term]
id: GO:0071534
name: obsolete zf-TRAF domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TRAF-type zinc finger (zf-TRAF) domain interaction." [GOC:amm, InterPro:IPR001293]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "TRAF-type zinc finger domain-mediated complex assembly" EXACT [GOC:mah]
synonym: "zinc finger TRAF-type domain-mediated complex assembly" EXACT [GOC:mah]
synonym: "zinc-finger-TRAF domain-mediated complex assembly" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071535
name: RING-like zinc finger domain binding
namespace: molecular_function
def: "Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain." [GOC:mah, InterPro:IPR014857]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071536
name: obsolete RING-like zinc finger domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RING-like zinc finger domain interaction." [GOC:amm, InterPro:IPR014857]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "RING-like domain-mediated complex assembly" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071537
name: obsolete C3HC4-type RING finger domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a C3HC4-type RING finger domain interaction." [GOC:amm, InterPro:IPR018957]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "zinc finger C3HC4 type domain-mediated complex assembly" EXACT [GOC:amm]
is_obsolete: true

[Term]
id: GO:0071538
name: obsolete SH2 domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an SH2 domain interaction." [GOC:amm]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
is_obsolete: true

[Term]
id: GO:0071539
name: protein localization to centrosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]
synonym: "protein localisation to centrosome" EXACT [GOC:mah]
is_a: GO:1905508 ! protein localization to microtubule organizing center

[Term]
id: GO:0071540
name: eukaryotic translation initiation factor 3 complex, eIF3e
namespace: cellular_component
def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185]
synonym: "eIF3e-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah]
is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex

[Term]
id: GO:0071541
name: eukaryotic translation initiation factor 3 complex, eIF3m
namespace: cellular_component
def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]
synonym: "eIF3m-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah]
is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex

[Term]
id: GO:0071542
name: dopaminergic neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0071543
name: diphosphoinositol polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729]
synonym: "diphosphoinositol polyphosphate metabolism" EXACT [GOC:mah]
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0071544
name: diphosphoinositol polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729]
synonym: "diphosphoinositol polyphosphate breakdown" EXACT [GOC:mah]
synonym: "diphosphoinositol polyphosphate catabolism" EXACT [GOC:mah]
synonym: "diphosphoinositol polyphosphate degradation" EXACT [GOC:mah]
is_a: GO:0071543 ! diphosphoinositol polyphosphate metabolic process
is_a: GO:0071545 ! inositol phosphate catabolic process

[Term]
id: GO:0071545
name: inositol phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]
synonym: "inositol phosphate breakdown" EXACT [GOC:mah]
synonym: "inositol phosphate catabolism" EXACT [GOC:mah]
synonym: "inositol phosphate degradation" EXACT [GOC:mah]
synonym: "myo-inositol phosphate catabolic process" NARROW [GOC:mah]
is_a: GO:0043647 ! inositol phosphate metabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0071546
name: pi-body
namespace: cellular_component
def: "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505]
synonym: "intermitochondrial cement" EXACT [GOC:sp]
is_a: GO:0043186 ! P granule

[Term]
id: GO:0071547
name: piP-body
namespace: cellular_component
def: "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway." [GOC:sp, PMID:20011505]
is_a: GO:0043186 ! P granule

[Term]
id: GO:0071548
name: response to dexamethasone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
synonym: "response to dexamethasone stimulus" EXACT [GOC:dos]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0071549
name: cellular response to dexamethasone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0071548 ! response to dexamethasone
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071550
name: death-inducing signaling complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway." [GOC:amm, GOC:mtg_apoptosis, InterPro:IPR000488]
synonym: "DD-mediated complex assembly" EXACT [GOC:mah]
synonym: "death domain-mediated complex assembly" EXACT []
synonym: "death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT []
synonym: "death-inducing signaling complex formation" EXACT []
synonym: "death-inducing signalling complex assembly" EXACT []
synonym: "DISC assembly" EXACT []
synonym: "DISC formation" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:0071551
name: RIP homotypic interaction motif binding
namespace: molecular_function
def: "Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases." [GOC:mah, PMID:11734559]
synonym: "RHIM binding" EXACT [GOC:mah]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071552
name: obsolete RIP homotypic interaction motif-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RIP homotypic interaction motif (RHIM) interaction." [GOC:amm, PMID:11734559]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "RHIM-mediated complex assembly" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071553
name: G protein-coupled pyrimidinergic nucleotide receptor activity
namespace: molecular_function
def: "Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:sl, PMID:10736418, PMID:12369950, PMID:15796906]
synonym: "G protein coupled pyrimidinergic nucleotide receptor activity" EXACT []
synonym: "G-protein coupled pyrimidinergic nucleotide receptor activity" EXACT []
synonym: "pyrimidinergic nucleotide receptor activity, G protein coupled" EXACT []
synonym: "pyrimidinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016502 ! nucleotide receptor activity

[Term]
id: GO:0071554
name: cell wall organization or biogenesis
namespace: biological_process
alt_id: GO:0070882
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah]
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular cell wall organization or biogenesis" EXACT []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0071555
name: cell wall organization
namespace: biological_process
alt_id: GO:0007047
alt_id: GO:0044234
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
synonym: "cell wall organisation" EXACT []
synonym: "cell wall organisation in other organism" EXACT [GOC:mah]
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "cell wall organization at cellular level" EXACT [GOC:mah]
synonym: "cell wall organization in other organism" EXACT []
synonym: "cellular cell wall organisation" EXACT []
synonym: "cellular cell wall organization" EXACT []
is_a: GO:0045229 ! external encapsulating structure organization
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0071556
name: obsolete integral component of lumenal side of endoplasmic reticulum membrane
namespace: cellular_component
def: "OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to ER membrane, lumenal side" EXACT [GOC:vw]
synonym: "integral to lumenal leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab]
synonym: "integral to lumenal side of endoplasmic reticulum membrane" NARROW []
synonym: "integral to lumenal side of ER membrane" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0098553

[Term]
id: GO:0071557
name: obsolete histone H3-K27 demethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638]
comment: This term was obsoleted because it represents a molecular function.
synonym: "H3K27 demethylation" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071558
name: histone H3K27me2/H3K27me3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [GOC:sp, PMID:20622853]
synonym: "histone demethylase activity (H3-K27 specific)" BROAD []
synonym: "histone H3-tri/di-methyl-lysine-27 demethylase activity" EXACT []
synonym: "histone H3K27me2 demethylase activity" RELATED []
synonym: "histone H3K27me3 demethylase activity" RELATED []
xref: EC:1.14.11.68
xref: Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter"
xref: Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin"
xref: Reactome:R-HSA-5617887 "HOXC4 chromatin is activated"
xref: Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)"
xref: Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)"
xref: RHEA:60224
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0141052 ! histone H3 demethylase activity

[Term]
id: GO:0071559
name: response to transforming growth factor beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah]
synonym: "response to TGF-beta stimulus" EXACT [GOC:mah]
synonym: "response to TGFbeta stimulus" EXACT [GOC:mah]
synonym: "response to transforming growth factor beta stimulus" EXACT [GOC:dos]
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:0071560
name: cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]
synonym: "cellular response to TGF-beta stimulus" EXACT [GOC:mah]
synonym: "cellular response to TGFbeta stimulus" EXACT [GOC:mah]
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071559 ! response to transforming growth factor beta

[Term]
id: GO:0071561
name: nucleus-vacuole junction
namespace: cellular_component
def: "An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880]
synonym: "nucleus-vacuole membrane contact site" EXACT [GOC:mah]
synonym: "NV junction" EXACT [GOC:jp, PMID:16709156]
synonym: "NVJ" EXACT [GOC:mah, PMID:16806880]
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0071562
name: nucleus-vacuole junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction (NVJ), membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. The NVJ plays roles in piecemeal microautophagy of the nucleus and in the cytoplasm-to-vacuole targeting pathway." [GOC:jp, PMID:16709156, PMID:28533415]
synonym: "nucleus-vacuole junction formation" EXACT [GOC:jp]
synonym: "NV junction assembly" EXACT [GOC:jp, PMID:16709156]
synonym: "NV junction formation" EXACT [GOC:jp, PMID:16709156]
synonym: "NVJ assembly" EXACT [GOC:mah, PMID:16806880]
synonym: "NVJ formation" EXACT [GOC:mah, PMID:16806880]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0140056 ! organelle localization by membrane tethering

[Term]
id: GO:0071563
name: Myo2p-Vac17p-Vac8p transport complex
namespace: cellular_component
def: "A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p." [GOC:jp, PMID:12594460]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0071564
name: npBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0071565
name: nBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth." [GOC:mah, GOC:ss, PMID:17640523]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0071566
name: UFM1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:sp, PMID:20018847]
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0071567
name: deUFMylase activity
namespace: molecular_function
def: "A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated." [GOC:sp, PMID:17182609, PMID:20018847]
synonym: "UFM1 hydrolase activity" EXACT []
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0019783 ! ubiquitin-like protein peptidase activity

[Term]
id: GO:0071568
name: UFM1 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages." [GOC:sp, PMID:20018847]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0071569
name: protein ufmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0071570
name: cement gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed." [GOC:bf]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0071571
name: obsolete LRR domain-mediated complex assembly
namespace: biological_process
def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an LRR (leucine-rich repeat) domain interaction." [GOC:amm, InterPro:IPR001611]
comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex.
synonym: "leucine-rich repeat domain-mediated complex assembly" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071572
name: obsolete histone H3-K56 deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0071573
name: shelterin complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a shelterin complex. A shelterin complex is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase." [GOC:mah, GOC:vw]
synonym: "Pot1 complex assembly" RELATED [GOC:mah, GOC:vw]
synonym: "Pot1-Tpz1 complex assembly" RELATED [GOC:mah, GOC:vw]
synonym: "shelterin complex formation" RELATED [GOC:mah, GOC:vw]
synonym: "telosome assembly" EXACT []
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0032200 ! telomere organization

[Term]
id: GO:0071574
name: protein localization to medial cortex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the medial cortex." [GOC:mah]
synonym: "protein localisation to medial cortex" EXACT [GOC:mah]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:0072741 ! protein localization to cell division site

[Term]
id: GO:0071575
name: obsolete integral component of external side of plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "integral to external side of plasma membrane" NARROW []
is_obsolete: true
replaced_by: GO:0009897

[Term]
id: GO:0071576
name: tetrahydrodictyopterin binding
namespace: molecular_function
def: "Binding to tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one." [GOC:mah, GOC:vw]
synonym: "D-threo-tetrahydrobiopterin" EXACT [GOC:mah]
synonym: "DH4 binding" EXACT [GOC:mah]
is_a: GO:0034617 ! tetrahydrobiopterin binding

[Term]
id: GO:0071577
name: zinc ion transmembrane transport
namespace: biological_process
def: "A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "zinc II ion transmembrane transport" EXACT []
synonym: "zinc ion membrane transport" EXACT []
synonym: "zinc transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006829 ! zinc ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0071578
name: zinc ion import across plasma membrane
namespace: biological_process
alt_id: GO:0006830
alt_id: GO:0006831
alt_id: GO:0044749
alt_id: GO:0140160
def: "The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:18637840]
synonym: "high-affinity zinc II ion transmembrane import" NARROW []
synonym: "high-affinity zinc II ion transport" NARROW []
synonym: "low-affinity zinc II ion transport" NARROW []
synonym: "zinc II ion plasma membrane import" EXACT []
synonym: "zinc II ion transmembrane import" EXACT []
synonym: "zinc import" EXACT [GOC:mah]
synonym: "zinc ion import into cell" EXACT []
synonym: "zinc ion transmembrane import" RELATED []
synonym: "zinc uptake" EXACT [GOC:mah]
is_a: GO:0071577 ! zinc ion transmembrane transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:0071579
name: regulation of zinc ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006829 ! zinc ion transport

[Term]
id: GO:0071580
name: regulation of zinc ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
synonym: "regulation of zinc ion membrane transport" EXACT []
is_a: GO:0071579 ! regulation of zinc ion transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: regulates GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0071581
name: regulation of zinc ion transmembrane import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zinc ion import." [GOC:BHF, GOC:mah]
is_a: GO:0071580 ! regulation of zinc ion transmembrane transport
relationship: regulates GO:0071578 ! zinc ion import across plasma membrane

[Term]
id: GO:0071582
name: negative regulation of zinc ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
is_a: GO:0071579 ! regulation of zinc ion transport
relationship: negatively_regulates GO:0006829 ! zinc ion transport

[Term]
id: GO:0071583
name: negative regulation of zinc ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
synonym: "negative regulation of zinc ion membrane transport" EXACT []
is_a: GO:0071580 ! regulation of zinc ion transmembrane transport
is_a: GO:0071582 ! negative regulation of zinc ion transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
relationship: negatively_regulates GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0071584
name: negative regulation of zinc ion transmembrane import
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zinc ion import." [GOC:BHF, GOC:mah]
is_a: GO:0071581 ! regulation of zinc ion transmembrane import
is_a: GO:0071583 ! negative regulation of zinc ion transmembrane transport
relationship: negatively_regulates GO:0071578 ! zinc ion import across plasma membrane

[Term]
id: GO:0071585
name: detoxification of cadmium ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, GOC:kmv, PMID:16741752]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:1990170 ! stress response to cadmium ion

[Term]
id: GO:0071586
name: CAAX-box protein processing
namespace: biological_process
def: "The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0080120 ! CAAX-box protein maturation

[Term]
id: GO:0071587
name: obsolete CAAX-box protein modification
namespace: biological_process
def: "OBSOLETE. The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0071588
name: hydrogen peroxide mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the detection of hydrogen peroxide (H2O2)." [GOC:mah, PMID:17043891]
synonym: "H2O2 mediated signaling pathway" EXACT [GOC:mah]
synonym: "hydrogen peroxide mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0071589
name: pyridine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah]
synonym: "pyridine nucleoside anabolism" EXACT [GOC:mah]
synonym: "pyridine nucleoside biosynthesis" EXACT [GOC:mah]
synonym: "pyridine nucleoside formation" EXACT [GOC:mah]
synonym: "pyridine nucleoside synthesis" EXACT [GOC:mah]
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0070637 ! pyridine nucleoside metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0071590
name: nicotinamide riboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [GOC:mah, PMID:19846558]
synonym: "N-ribosylnicotinamide biosynthetic process" EXACT [CHEBI:15927]
synonym: "nicotinamide riboside anabolism" EXACT [GOC:mah]
synonym: "nicotinamide riboside biosynthesis" EXACT [GOC:mah]
synonym: "nicotinamide riboside formation" EXACT [GOC:mah]
synonym: "nicotinamide riboside synthesis" EXACT [GOC:mah]
is_a: GO:0046495 ! nicotinamide riboside metabolic process
is_a: GO:0071589 ! pyridine nucleoside biosynthetic process

[Term]
id: GO:0071591
name: nicotinic acid riboside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [GOC:mah, PMID:19846558]
synonym: "D-ribosylnicotinic acid metabolic process" EXACT [CHEBI:27748]
synonym: "nicotinic acid riboside metabolism" EXACT [GOC:mah]
is_a: GO:0070637 ! pyridine nucleoside metabolic process

[Term]
id: GO:0071592
name: nicotinic acid riboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [GOC:mah, PMID:19846558]
synonym: "D-ribosylnicotinic acid biosynthetic process" EXACT [CHEBI:27748]
synonym: "nicotinic acid riboside anabolism" EXACT [GOC:mah]
synonym: "nicotinic acid riboside biosynthesis" EXACT [GOC:mah]
synonym: "nicotinic acid riboside formation" EXACT [GOC:mah]
synonym: "nicotinic acid riboside synthesis" EXACT [GOC:mah]
is_a: GO:0071589 ! pyridine nucleoside biosynthetic process
is_a: GO:0071591 ! nicotinic acid riboside metabolic process

[Term]
id: GO:0071593
name: lymphocyte aggregation
namespace: biological_process
def: "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules." [GOC:sl]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0071594
name: thymocyte aggregation
namespace: biological_process
def: "The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules." [GOC:sl, PMID:1382990]
synonym: "immature T cell aggregation" BROAD [CL:0000893, GOC:sl]
synonym: "immature T-cell aggregation" BROAD [CL:0000893, GOC:mah]
synonym: "immature T-lymphocyte aggregation" EXACT [CL:0000893, GOC:mah]
synonym: "T cell precursor aggregation" EXACT [GOC:sl]
synonym: "thymic lymphocyte aggregation" EXACT [GOC:sl]
is_a: GO:0070489 ! T cell aggregation

[Term]
id: GO:0071595
name: Nem1-Spo7 phosphatase complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network

[Term]
id: GO:0071596
name: ubiquitin-dependent protein catabolic process via the N-end rule pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437]
synonym: "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT [GOC:mah]
synonym: "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT [GOC:mah]
synonym: "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT [GOC:mah]
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0071597
name: cellular birth scar
namespace: cellular_component
def: "Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." [GOC:mcc, PMID:16672383, PMID:7730409]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0071598
name: neuronal ribonucleoprotein granule
namespace: cellular_component
def: "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989]
synonym: "neuronal RNA granule" NARROW []
synonym: "neuronal RNP granule" EXACT []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
relationship: part_of GO:0120111 ! neuron projection cytoplasm

[Term]
id: GO:0071599
name: otic vesicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah]
is_a: GO:0007423 ! sensory organ development
is_a: GO:0035295 ! tube development
is_a: GO:0048839 ! inner ear development
is_a: GO:0060429 ! epithelium development

[Term]
id: GO:0071600
name: otic vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah]
is_a: GO:0042472 ! inner ear morphogenesis
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0071599 ! otic vesicle development

[Term]
id: GO:0071601
name: sphere organelle
namespace: cellular_component
def: "A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins." [PMID:7758244, PMID:8349728]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0071602
name: phytosphingosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol." [GOC:mah]
synonym: "phytosphingosine anabolism" EXACT [GOC:mah]
synonym: "phytosphingosine biosynthesis" EXACT [GOC:mah]
synonym: "phytosphingosine formation" EXACT [GOC:mah]
synonym: "phytosphingosine synthesis" EXACT [GOC:mah]
is_a: GO:0006671 ! phytosphingosine metabolic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0071603
name: endothelial cell-cell adhesion
namespace: biological_process
def: "The attachment of an endothelial cell to another endothelial cell via adhesion molecules." [GOC:BHF]
is_a: GO:0090136 ! epithelial cell-cell adhesion

[Term]
id: GO:0071604
name: transforming growth factor beta production
namespace: biological_process
alt_id: GO:0038044
def: "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv, PMID:16891311, PMID:2022183]
synonym: "TGF-B production" EXACT [GOC:mah]
synonym: "TGF-beta production" EXACT [PMID:2022183]
synonym: "TGFb production" EXACT [GOC:rv]
synonym: "TGFbeta production" EXACT [PMID:16891311]
synonym: "transforming growth factor-beta production" EXACT [GOC:bf]
synonym: "transforming growth factor-beta secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0071605
name: monocyte chemotactic protein-1 production
namespace: biological_process
def: "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL2 production" EXACT [GOC:add, GOC:rv]
synonym: "MCP-1 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071606
name: chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL4 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1b production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071607
name: macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL9 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 9 production" EXACT [GOC:add, GOC:rv]
synonym: "MIP-1g production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071608
name: macrophage inflammatory protein-1 alpha production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL3 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 3 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1a production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071609
name: chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL5 production" EXACT [GOC:add, GOC:rv]
synonym: "RANTES production" EXACT [GOC:bf]
synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071610
name: chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL1 production" EXACT [GOC:add, GOC:rv]
synonym: "T cell activation 3 production" EXACT [GOC:add, GOC:rv]
synonym: "TCA-3 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071611
name: granulocyte colony-stimulating factor production
namespace: biological_process
def: "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "colony stimulating factor 3 (granulocyte) production" EXACT [GOC:add]
synonym: "CSF3 production" EXACT [GOC:add]
synonym: "filgrastim production" EXACT [GOC:add]
synonym: "G-CSF production" EXACT [GOC:add]
synonym: "granulocyte colony stimulating factor production" EXACT []
synonym: "lenograstim production" EXACT [GOC:add]
synonym: "pluripoietin production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0071612
name: IP-10 production
namespace: biological_process
def: "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "chemokine (C-C motif) ligand 10 production" EXACT [GOC:add, GOC:rv]
synonym: "CXCL10 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071613
name: granzyme B production
namespace: biological_process
def: "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0071614
name: linoleic acid epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid." [GOC:BHF, PMID:11042099]
synonym: "linoleic acid monooxygenase activity" EXACT [GOC:mah]
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0071615
name: obsolete oxidative deethylation
namespace: biological_process
def: "OBSOLETE. The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0071616
name: acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk]
synonym: "acyl-CoA anabolism" EXACT [GOC:mah]
synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah]
synonym: "acyl-CoA formation" EXACT [GOC:mah]
synonym: "acyl-CoA synthesis" EXACT [GOC:mah]
is_a: GO:0006637 ! acyl-CoA metabolic process
is_a: GO:0035384 ! thioester biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0071617
name: lysophospholipid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0071618
name: lysophosphatidylethanolamine acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine." [GOC:cjk]
is_a: GO:0071617 ! lysophospholipid acyltransferase activity

[Term]
id: GO:0071619
name: obsolete phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans." [GOC:krc, PMID:17079683]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006366
consider: GO:0140834

[Term]
id: GO:0071620
name: obsolete phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans)." [GOC:krc, PMID:17079683]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006366
consider: GO:0140836

[Term]
id: GO:0071621
name: granulocyte chemotaxis
namespace: biological_process
def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097530 ! granulocyte migration

[Term]
id: GO:0071622
name: regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0071623
name: negative regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
relationship: negatively_regulates GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0071624
name: positive regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
relationship: positively_regulates GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0071625
name: vocalization behavior
namespace: biological_process
def: "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." [GOC:mah]
synonym: "vocalisation behaviour" EXACT [GOC:mah]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0071626
name: mastication
namespace: biological_process
def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg]
synonym: "chewing" EXACT [GOC:mah]
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0071627
name: obsolete integral component of fungal-type vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to fungal-type vacuolar membrane" NARROW []
is_obsolete: true
replaced_by: GO:0000329

[Term]
id: GO:0071628
name: obsolete intrinsic component of fungal-type vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of a fungal-type vacuole membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0000329

[Term]
id: GO:0071629
name: cytoplasm protein quality control by the ubiquitin-proteasome system
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635]
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah]
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah]
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah]
synonym: "ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome" EXACT []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
is_a: GO:0140455 ! cytoplasm protein quality control
relationship: part_of GO:0071218 ! cellular response to misfolded protein

[Term]
id: GO:0071630
name: nuclear protein quality control by the ubiquitin-proteasome system
namespace: biological_process
def: "A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation." [PMID:20080635, PMID:21211726]
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah]
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah]
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah]
synonym: "ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome" EXACT []
is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
relationship: part_of GO:0071218 ! cellular response to misfolded protein

[Term]
id: GO:0071631
name: mating pheromone secretion involved in positive regulation of conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0071833
def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that positively regulates a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah]
synonym: "mating-type pheromone secretion involved in conjugation with cellular fusion" EXACT [GOC:vw]
synonym: "peptide pheromone export involved in positive regulation of conjugation with cellular fusion" RELATED []
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion
is_a: GO:0071834 ! mating pheromone secretion

[Term]
id: GO:0071632
name: optomotor response
namespace: biological_process
def: "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195]
xref: Wikipedia:Optomotor_response
is_a: GO:0007634 ! optokinetic behavior

[Term]
id: GO:0071633
name: obsolete dihydroceramidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine." [GOC:mah, PMID:10900202]
comment: The reason for obsoletion is that this term represents a specific substrate of GO:0017040 N-acylsphingosine amidohydrolase activity.
is_obsolete: true
replaced_by: GO:0017040

[Term]
id: GO:0071634
name: regulation of transforming growth factor beta production
namespace: biological_process
alt_id: GO:2001201
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "regulation of TGF-B production" EXACT [GOC:mah]
synonym: "regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "regulation of TGFB production" EXACT [GOC:mah]
synonym: "regulation of TGFbeta production" EXACT [GOC:obol]
synonym: "regulation of transforming growth factor-beta production" EXACT [GOC:bf]
synonym: "regulation of transforming growth factor-beta secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0071635
name: negative regulation of transforming growth factor beta production
namespace: biological_process
alt_id: GO:2001202
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "negative regulation of TGF-B production" EXACT [GOC:mah]
synonym: "negative regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "negative regulation of TGFB production" EXACT [GOC:mah]
synonym: "negative regulation of TGFbeta production" EXACT [GOC:obol]
synonym: "negative regulation of transforming growth factor-beta production" EXACT [GOC:bf]
synonym: "negative regulation of transforming growth factor-beta secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0071634 ! regulation of transforming growth factor beta production
relationship: negatively_regulates GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0071636
name: positive regulation of transforming growth factor beta production
namespace: biological_process
alt_id: GO:2001203
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "positive regulation of TGF-B production" EXACT [GOC:mah]
synonym: "positive regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "positive regulation of TGFB production" EXACT [GOC:mah]
synonym: "positive regulation of TGFbeta production" EXACT [GOC:obol]
synonym: "positive regulation of transforming growth factor-beta production" EXACT [GOC:bf]
synonym: "positive regulation of transforming growth factor-beta secretion" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0071634 ! regulation of transforming growth factor beta production
relationship: positively_regulates GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0071637
name: regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "regulation of CCL2 production" EXACT [GOC:mah]
synonym: "regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071605 ! monocyte chemotactic protein-1 production

[Term]
id: GO:0071638
name: negative regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "negative regulation of CCL2 production" EXACT [GOC:mah]
synonym: "negative regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production
relationship: negatively_regulates GO:0071605 ! monocyte chemotactic protein-1 production

[Term]
id: GO:0071639
name: positive regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "positive regulation of CCL2 production" EXACT [GOC:mah]
synonym: "positive regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production
relationship: positively_regulates GO:0071605 ! monocyte chemotactic protein-1 production

[Term]
id: GO:0071640
name: regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "regulation of CCL3 production" EXACT [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production

[Term]
id: GO:0071641
name: negative regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "negative regulation of CCL3 production" EXACT [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "negative regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production
relationship: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production

[Term]
id: GO:0071642
name: positive regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "positive regulation of CCL3 production" EXACT [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "positive regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production
relationship: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production

[Term]
id: GO:0071643
name: regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "regulation of CCL4 production" EXACT [GOC:mah]
synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production

[Term]
id: GO:0071644
name: negative regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "negative regulation of CCL4 production" EXACT [GOC:mah]
synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "negative regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production
relationship: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production

[Term]
id: GO:0071645
name: positive regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "positive regulation of CCL4 production" EXACT [GOC:mah]
synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "positive regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production
relationship: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production

[Term]
id: GO:0071646
name: regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "regulation of CCL9 production" EXACT [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production

[Term]
id: GO:0071647
name: negative regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "negative regulation of CCL9 production" EXACT [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "negative regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production
relationship: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production

[Term]
id: GO:0071648
name: positive regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "positive regulation of CCL9 production" EXACT [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "positive regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production
relationship: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production

[Term]
id: GO:0071649
name: regulation of chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah]
synonym: "regulation of CCL5 production" EXACT [GOC:mah]
synonym: "regulation of RANTES production" EXACT [GOC:bf]
synonym: "regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production

[Term]
id: GO:0071650
name: negative regulation of chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah]
synonym: "negative regulation of CCL5 production" EXACT [GOC:mah]
synonym: "negative regulation of RANTES production" EXACT [GOC:bf]
synonym: "negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production
relationship: negatively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production

[Term]
id: GO:0071651
name: positive regulation of chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah]
synonym: "positive regulation of CCL5 production" EXACT [GOC:mah]
synonym: "positive regulation of RANTES production" EXACT [GOC:bf]
synonym: "positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production
relationship: positively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production

[Term]
id: GO:0071652
name: regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "regulation of CCL1 production" EXACT [GOC:mah]
synonym: "regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production

[Term]
id: GO:0071653
name: negative regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "negative regulation of CCL1 production" EXACT [GOC:mah]
synonym: "negative regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "negative regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production
relationship: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production

[Term]
id: GO:0071654
name: positive regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "positive regulation of CCL1 production" EXACT [GOC:mah]
synonym: "positive regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "positive regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production
relationship: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production

[Term]
id: GO:0071655
name: regulation of granulocyte colony-stimulating factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah]
synonym: "regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "regulation of CSF3 production" EXACT [GOC:mah]
synonym: "regulation of filgrastim production" EXACT [GOC:mah]
synonym: "regulation of G-CSF production" EXACT [GOC:mah]
synonym: "regulation of granulocyte colony stimulating factor production" EXACT []
synonym: "regulation of lenograstim production" EXACT [GOC:mah]
synonym: "regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production
relationship: regulates GO:0071611 ! granulocyte colony-stimulating factor production

[Term]
id: GO:0071656
name: negative regulation of granulocyte colony-stimulating factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah]
synonym: "negative regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "negative regulation of CSF3 production" EXACT [GOC:mah]
synonym: "negative regulation of filgrastim production" EXACT [GOC:mah]
synonym: "negative regulation of G-CSF production" EXACT [GOC:mah]
synonym: "negative regulation of granulocyte colony stimulating factor production" EXACT []
synonym: "negative regulation of lenograstim production" EXACT [GOC:mah]
synonym: "negative regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production
is_a: GO:1901257 ! negative regulation of macrophage colony-stimulating factor production
relationship: negatively_regulates GO:0071611 ! granulocyte colony-stimulating factor production

[Term]
id: GO:0071657
name: positive regulation of granulocyte colony-stimulating factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah]
synonym: "positive regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "positive regulation of CSF3 production" EXACT [GOC:mah]
synonym: "positive regulation of filgrastim production" EXACT [GOC:mah]
synonym: "positive regulation of G-CSF production" EXACT [GOC:mah]
synonym: "positive regulation of granulocyte colony stimulating factor production" EXACT []
synonym: "positive regulation of lenograstim production" EXACT [GOC:mah]
synonym: "positive regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production
is_a: GO:1901258 ! positive regulation of macrophage colony-stimulating factor production
relationship: positively_regulates GO:0071611 ! granulocyte colony-stimulating factor production

[Term]
id: GO:0071658
name: regulation of IP-10 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071612 ! IP-10 production

[Term]
id: GO:0071659
name: negative regulation of IP-10 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "negative regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071658 ! regulation of IP-10 production
relationship: negatively_regulates GO:0071612 ! IP-10 production

[Term]
id: GO:0071660
name: positive regulation of IP-10 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "positive regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071658 ! regulation of IP-10 production
relationship: positively_regulates GO:0071612 ! IP-10 production

[Term]
id: GO:0071661
name: regulation of granzyme B production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: regulates GO:0071613 ! granzyme B production

[Term]
id: GO:0071662
name: negative regulation of granzyme B production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0071661 ! regulation of granzyme B production
relationship: negatively_regulates GO:0071613 ! granzyme B production

[Term]
id: GO:0071663
name: positive regulation of granzyme B production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0071661 ! regulation of granzyme B production
relationship: positively_regulates GO:0071613 ! granzyme B production

[Term]
id: GO:0071664
name: catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054]
synonym: "catenin-TCF4 complex" EXACT [GOC:mah]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071665
name: gamma-catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054]
synonym: "gamma-catenin-TCF4 complex" EXACT [GOC:mah]
synonym: "plakoglobin-TCF4 complex" EXACT [PMID:14661054]
is_a: GO:0071664 ! catenin-TCF7L2 complex

[Term]
id: GO:0071666
name: Slit-Robo signaling complex
namespace: cellular_component
def: "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766]
synonym: "Slit-Robo signalling complex" EXACT [GOC:mah]
is_a: GO:0032992 ! protein-carbohydrate complex

[Term]
id: GO:0071667
name: DNA/RNA hybrid binding
namespace: molecular_function
def: "Binding to a RNA/DNA hybrid." [GOC:ecd]
synonym: "RNA/DNA hybrid binding" EXACT [GOC:ecd]
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0071668
name: plant-type cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall." [GOC:mah]
synonym: "plant cell wall assembly" NARROW []
is_a: GO:0009664 ! plant-type cell wall organization
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0071669
name: plant-type cell wall organization or biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [GOC:ecd, GOC:mah]
synonym: "plant-type cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0071670
name: smooth muscle cell chemotaxis
namespace: biological_process
def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah]
is_a: GO:0014909 ! smooth muscle cell migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0071671
name: regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0071670 ! smooth muscle cell chemotaxis

[Term]
id: GO:0071672
name: negative regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
relationship: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis

[Term]
id: GO:0071673
name: positive regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
relationship: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis

[Term]
id: GO:0071674
name: mononuclear cell migration
namespace: biological_process
def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0071675
name: regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
relationship: regulates GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0071676
name: negative regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: negatively_regulates GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0071677
name: positive regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "activation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: positively_regulates GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0071678
name: olfactory bulb axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]
synonym: "olfactory bulb axon pathfinding" EXACT [GOC:vk]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0071679
name: commissural neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]
synonym: "commissural neuron axon pathfinding" EXACT [GOC:vk]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0071680
name: response to indole-3-methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf]
synonym: "response to indole-3-carbinol" EXACT [CHEBI:24814]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0071681
name: cellular response to indole-3-methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf]
synonym: "cellular response to indole-3-carbinol" EXACT [CHEBI:24814]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071680 ! response to indole-3-methanol
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071682
name: endocytic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0030139 ! endocytic vesicle

[Term]
id: GO:0071683
name: sensory dendrite
namespace: cellular_component
def: "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah]
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0071684
name: organism emergence from protective structure
namespace: biological_process
def: "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case." [GOC:mah]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0071685
name: NADH dehydrogenase complex (plastoquinone)
namespace: cellular_component
def: "An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids." [DOI:10.1078/0176-1617-00593, GOC:mah]
is_a: GO:0010598 ! NAD(P)H dehydrogenase complex (plastoquinone)
is_a: GO:0030964 ! NADH dehydrogenase complex
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0071686
name: obsolete horsetail nucleus
namespace: cellular_component
def: "OBSOLETE. The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:vw, PMID:15030757]
comment: This term was made obsolete at the request of PomBase as the concept can be expressed by annotating to a less granular term and using annotation extensions.
is_obsolete: true

[Term]
id: GO:0071687
name: obsolete horsetail nucleus leading edge
namespace: cellular_component
def: "OBSOLETE. The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:mah, GOC:vw, PMID:15030757]
comment: This term was made obsolete at the request of PomBase as the concept can be expressed by annotating to a less granular term and using annotation extensions.
is_obsolete: true

[Term]
id: GO:0071688
name: striated muscle myosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle." [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0031034 ! myosin filament assembly
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0071689
name: muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0071690
name: cardiac muscle myosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle." [GOC:mah]
is_a: GO:0071688 ! striated muscle myosin thick filament assembly
relationship: part_of GO:0055003 ! cardiac myofibril assembly

[Term]
id: GO:0071691
name: cardiac muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0055003 ! cardiac myofibril assembly

[Term]
id: GO:0071692
name: protein localization to extracellular region
namespace: biological_process
def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah]
synonym: "protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "protein localization in extracellular region" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0071693
name: protein transport within extracellular region
namespace: biological_process
def: "The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015031 ! protein transport
is_a: GO:0035592 ! establishment of protein localization to extracellular region

[Term]
id: GO:0071694
name: maintenance of protein location in extracellular region
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0045185 ! maintenance of protein location
relationship: part_of GO:0071692 ! protein localization to extracellular region

[Term]
id: GO:0071695
name: anatomical structure maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0071696
name: ectodermal placode development
namespace: biological_process
def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0071697
name: ectodermal placode morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0071696 ! ectodermal placode development

[Term]
id: GO:0071698
name: olfactory placode development
namespace: biological_process
def: "The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah]
is_a: GO:0071696 ! ectodermal placode development

[Term]
id: GO:0071699
name: olfactory placode morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0071697 ! ectodermal placode morphogenesis
relationship: part_of GO:0071698 ! olfactory placode development

[Term]
id: GO:0071700
name: olfactory placode maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0071698 ! olfactory placode development

[Term]
id: GO:0071701
name: obsolete regulation of MAPK export from nucleus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:dgf]
comment: The reason for obsoletion is that this term represents a specific substrate, out of scope for GO.
synonym: "regulation of cytoplasmic translocation of MAP kinase" EXACT [GOC:mah]
synonym: "regulation of cytoplasmic translocation of mitogen-activated protein kinase" EXACT [GOC:mah]
synonym: "regulation of MAPK export from cell nucleus" EXACT [GOC:mah]
synonym: "regulation of MAPK export out of nucleus" EXACT [GOC:mah]
synonym: "regulation of MAPK transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "regulation of MAPK-nucleus export" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0071702
name: obsolete organic substance transport
namespace: biological_process
def: "OBSOLETE. The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0071703
name: obsolete detection of organic substance
namespace: biological_process
def: "OBSOLETE. The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal." [GOC:mah]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0071704
name: obsolete organic substance metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0071705
name: nitrogen compound transport
namespace: biological_process
def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006810 ! transport

[Term]
id: GO:0071706
name: tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "TNF superfamily production" RELATED [GOC:rv]
synonym: "TNFSF cytokine production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0071707
name: immunoglobulin heavy chain V-D-J recombination
namespace: biological_process
def: "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149]
synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add]
synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add]
synonym: "immunoglobulin V-D-J joining" EXACT [GOC:add]
is_a: GO:0033152 ! immunoglobulin V(D)J recombination

[Term]
id: GO:0071708
name: immunoglobulin light chain V-J recombination
namespace: biological_process
def: "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149]
synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add]
synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add]
synonym: "immunoglobulin V-J joining" EXACT [GOC:add]
is_a: GO:0033152 ! immunoglobulin V(D)J recombination

[Term]
id: GO:0071709
name: membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0044091 ! membrane biogenesis

[Term]
id: GO:0071710
name: membrane macromolecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell." [GOC:mah]
synonym: "membrane macromolecule anabolism" EXACT [GOC:mah]
synonym: "membrane macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "membrane macromolecule formation" EXACT [GOC:mah]
synonym: "membrane macromolecule synthesis" EXACT [GOC:mah]
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0044091 ! membrane biogenesis

[Term]
id: GO:0071711
name: basement membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer.
synonym: "basement membrane organisation" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0071712
name: obsolete ER-associated misfolded protein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [PMID:14607247, PMID:19520858]
comment: This term was added in error (identical in meaning to parent ERAD pathway)
synonym: "endoplasmic reticulum-associated misfolded protein catabolism" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0036503

[Term]
id: GO:0071713
name: para-aminobenzoyl-glutamate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate." [GOC:imk, PMID:20190044]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0071714
name: icosanoid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of icosanoids from one side of a membrane to the other." [GOC:sl]
synonym: "eicosanoid transmembrane transporter activity" EXACT [GOC:sl]
xref: Reactome:R-HSA-428990 "SLC27A1 transports arachidonate across the ER membrane"
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:0071715
name: icosanoid transport
namespace: biological_process
def: "The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [GOC:mah]
synonym: "eicosanoid transport" EXACT [GOC:sl]
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0071716
name: leukotriene transport
namespace: biological_process
def: "The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [GOC:mah]
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:0071717
name: thromboxane transport
namespace: biological_process
def: "The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [GOC:mah]
is_a: GO:0015908 ! fatty acid transport
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:0071718
name: sodium-independent icosanoid transport
namespace: biological_process
def: "The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [GOC:mah, GOC:sl]
synonym: "sodium-independent eicosanoid transport" EXACT [GOC:sl]
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:0071719
name: sodium-independent leukotriene transport
namespace: biological_process
def: "The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [GOC:mah]
is_a: GO:0071716 ! leukotriene transport
is_a: GO:0071718 ! sodium-independent icosanoid transport

[Term]
id: GO:0071720
name: sodium-independent prostaglandin transport
namespace: biological_process
def: "The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015732 ! prostaglandin transport
is_a: GO:0071718 ! sodium-independent icosanoid transport

[Term]
id: GO:0071721
name: sodium-independent thromboxane transport
namespace: biological_process
def: "The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [GOC:mah]
is_a: GO:0071717 ! thromboxane transport
is_a: GO:0071718 ! sodium-independent icosanoid transport

[Term]
id: GO:0071722
name: detoxification of arsenic-containing substance
namespace: biological_process
def: "Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds." [GOC:kmv, PMID:11313333, PMID:20221439]
synonym: "detoxification of arsenic" EXACT []
is_a: GO:0098754 ! detoxification
relationship: part_of GO:0046685 ! response to arsenic-containing substance

[Term]
id: GO:0071723
name: lipopeptide binding
namespace: molecular_function
def: "Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "bacterial lipopeptide binding" NARROW [GOC:add]
synonym: "bacterial lipoprotein binding" RELATED [GOC:add]
is_a: GO:0008289 ! lipid binding
is_a: GO:0033218 ! amide binding

[Term]
id: GO:0071724
name: response to diacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "response to diacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0070339 ! response to bacterial lipopeptide

[Term]
id: GO:0071725
name: response to triacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "response to triacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0070339 ! response to bacterial lipopeptide

[Term]
id: GO:0071726
name: cellular response to diacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "cellular response to diacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0071221 ! cellular response to bacterial lipopeptide
is_a: GO:0071724 ! response to diacyl bacterial lipopeptide

[Term]
id: GO:0071727
name: cellular response to triacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "cellular response to triacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0071221 ! cellular response to bacterial lipopeptide
is_a: GO:0071725 ! response to triacyl bacterial lipopeptide

[Term]
id: GO:0071728
name: beak development
namespace: biological_process
def: "The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0071729
name: beak morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0071728 ! beak development

[Term]
id: GO:0071730
name: beak formation
namespace: biological_process
def: "The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0071729 ! beak morphogenesis

[Term]
id: GO:0071731
name: response to nitric oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0071732
name: cellular response to nitric oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0071731 ! response to nitric oxide
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902170 ! cellular response to reactive nitrogen species

[Term]
id: GO:0071733
name: obsolete transcriptional activation by promoter-enhancer looping
namespace: biological_process
def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:mah, PMID:15060134, PMID:19923429]
comment: This term was obsoleted because it was defined like a molecular function.
synonym: "long-range enhancer-promoter communication" RELATED [PMID:15060134]
is_obsolete: true
consider: GO:0045893

[Term]
id: GO:0071734
name: obsolete biotin-[pyruvate-carboxylase] ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)." [GOC:mah, PMID:10551847]
comment: The reason for obsoletion is this term is more specific than the specificity of any known gene product.
synonym: "biotin-[pyruvate carboxylase] ligase activity" EXACT [GOC:jp]
synonym: "biotin-[pyruvate carboxylase] synthetase activity" EXACT [GOC:mah]
synonym: "biotin-pyruvate carboxylase synthetase activity" EXACT [GOC:mah]
synonym: "biotin-pyruvate-carboxylase ligase activity" EXACT [GOC:mah]
synonym: "biotin:apo-pyruvate-carboxylase ligase" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0004077

[Term]
id: GO:0071735
name: IgG immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
synonym: "IgG1" NARROW [GOC:add]
synonym: "IgG2" NARROW [GOC:add]
synonym: "IgG2a" NARROW [GOC:add]
synonym: "IgG2b" NARROW [GOC:add]
synonym: "IgG2c" NARROW [GOC:add]
synonym: "IgG3" NARROW [GOC:add]
synonym: "IgG4" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071736
name: IgG immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
synonym: "IgG antibody" NARROW [GOC:add]
synonym: "IgG1 antibody" NARROW [GOC:add]
synonym: "IgG2 antibody" NARROW [GOC:add]
synonym: "IgG2a antibody" NARROW [GOC:add]
synonym: "IgG2b antibody" NARROW [GOC:add]
synonym: "IgG2c antibody" NARROW [GOC:add]
synonym: "IgG3 antibody" NARROW [GOC:add]
synonym: "IgG4 antibody" NARROW [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071735 ! IgG immunoglobulin complex

[Term]
id: GO:0071737
name: IgG B cell receptor complex
namespace: cellular_component
def: "An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196]
comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
synonym: "membrane-bound IgG" NARROW [GOC:add]
synonym: "membrane-bound IgG1" NARROW [GOC:add]
synonym: "membrane-bound IgG2" NARROW [GOC:add]
synonym: "membrane-bound IgG2a" NARROW [GOC:add]
synonym: "membrane-bound IgG2b" NARROW [GOC:add]
synonym: "membrane-bound IgG2c" NARROW [GOC:add]
synonym: "membrane-bound IgG3" NARROW [GOC:add]
synonym: "membrane-bound IgG4" NARROW [GOC:add]
synonym: "surface IgG" NARROW [GOC:add]
synonym: "surface IgG1" NARROW [GOC:add]
synonym: "surface IgG2" NARROW [GOC:add]
synonym: "surface IgG2a" NARROW [GOC:add]
synonym: "surface IgG2b" NARROW [GOC:add]
synonym: "surface IgG2c" NARROW [GOC:add]
synonym: "surface IgG3" NARROW [GOC:add]
synonym: "surface IgG4" NARROW [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071735 ! IgG immunoglobulin complex

[Term]
id: GO:0071738
name: IgD immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071739
name: IgD immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgD antibody" EXACT [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071738 ! IgD immunoglobulin complex

[Term]
id: GO:0071740
name: IgD B cell receptor complex
namespace: cellular_component
def: "An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgD" EXACT [GOC:add]
synonym: "surface IgD" EXACT [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071738 ! IgD immunoglobulin complex

[Term]
id: GO:0071741
name: IgD immunoglobulin complex, GPI-anchored
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "GPI-anchored IgD" EXACT [GOC:add]
is_a: GO:0071738 ! IgD immunoglobulin complex

[Term]
id: GO:0071742
name: IgE immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071743
name: IgE immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgE antibody" EXACT [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071742 ! IgE immunoglobulin complex

[Term]
id: GO:0071744
name: IgE B cell receptor complex
namespace: cellular_component
def: "An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196]
comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgE" EXACT [GOC:add]
synonym: "surface IgE" EXACT [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071742 ! IgE immunoglobulin complex

[Term]
id: GO:0071745
name: IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgA1 antibody" NARROW [GOC:add]
synonym: "IgA2 antibody" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071746
name: IgA immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgA antibody" EXACT [GOC:add]
synonym: "IgA1 antibody" NARROW [GOC:add]
synonym: "IgA2 antibody" NARROW [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071745 ! IgA immunoglobulin complex

[Term]
id: GO:0071747
name: IgA B cell receptor complex
namespace: cellular_component
def: "An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgA" NARROW [GOC:add]
synonym: "membrane-bound IgA1" NARROW [GOC:add]
synonym: "membrane-bound IgA2" NARROW [GOC:add]
synonym: "surface IgA" NARROW [GOC:add]
synonym: "surface IgA1" NARROW [GOC:add]
synonym: "surface IgA2" NARROW [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071745 ! IgA immunoglobulin complex

[Term]
id: GO:0071748
name: monomeric IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "monomeric IgA antibody" EXACT [GOC:add]
synonym: "monomeric IgA1 antibody" NARROW [GOC:add]
synonym: "monomeric IgA2 antibody" NARROW [GOC:add]
is_a: GO:0071746 ! IgA immunoglobulin complex, circulating

[Term]
id: GO:0071749
name: polymeric IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms.
synonym: "pIgA antibody" EXACT [GOC:add]
synonym: "pIgA1 antibody" NARROW [GOC:add]
synonym: "polymeric IgA antibody" EXACT [GOC:add]
synonym: "polymeric IgA1 antibody" NARROW [GOC:add]
is_a: GO:0071746 ! IgA immunoglobulin complex, circulating

[Term]
id: GO:0071750
name: dimeric IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.
synonym: "dimeric IgA antibody" EXACT [GOC:add]
synonym: "dimeric IgA1 antibody" NARROW [GOC:add]
is_a: GO:0071749 ! polymeric IgA immunoglobulin complex

[Term]
id: GO:0071751
name: secretory IgA immunoglobulin complex
namespace: cellular_component
def: "A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.
synonym: "secretory IgA antibody" EXACT [GOC:add]
synonym: "sIgA antibody" EXACT [GOC:add]
synonym: "sIgA1 antibody" NARROW [GOC:add]
is_a: GO:0071749 ! polymeric IgA immunoglobulin complex

[Term]
id: GO:0071752
name: secretory dimeric IgA immunoglobulin complex
namespace: cellular_component
def: "A dimeric form of secretory IgA immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.
synonym: "secretory dimeric IgA antibody" EXACT [GOC:add]
synonym: "secretory dimeric IgA1 antibody" NARROW [GOC:add]
is_a: GO:0071750 ! dimeric IgA immunoglobulin complex
is_a: GO:0071751 ! secretory IgA immunoglobulin complex

[Term]
id: GO:0071753
name: IgM immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071754
name: IgM immunoglobulin complex, circulating
namespace: cellular_component
def: "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgM antibody" EXACT [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071753 ! IgM immunoglobulin complex

[Term]
id: GO:0071755
name: IgM B cell receptor complex
namespace: cellular_component
def: "An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgM" NARROW [GOC:add]
synonym: "surface IgM" NARROW [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071753 ! IgM immunoglobulin complex

[Term]
id: GO:0071756
name: pentameric IgM immunoglobulin complex
namespace: cellular_component
def: "A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "pentameric IgM antibody" EXACT [GOC:add]
is_a: GO:0071754 ! IgM immunoglobulin complex, circulating

[Term]
id: GO:0071757
name: hexameric IgM immunoglobulin complex
namespace: cellular_component
def: "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "hexameric IgM antibody" EXACT [GOC:add]
is_a: GO:0071754 ! IgM immunoglobulin complex, circulating

[Term]
id: GO:0071758
name: IgW immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgW immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgW is found in fish.
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071759
name: IgX immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgX immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgX is found in amphibians.
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071760
name: IgY immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgY immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgY is found in amphibians, reptiles, and birds.
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071761
name: IgZ immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish." [GOC:add, ISBN:0781765196]
comment: Note that an IgZ immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgZ is found in bony fish, and called IgT in certain species, such as trout.
synonym: "IgT antibody" NARROW [GOC:add]
synonym: "IgT immunoglobulin complex" EXACT [ISBN:0781765196]
synonym: "IgZ antibody" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071762
name: heavy chain immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains." [GOC:add, ISBN:0781765196, PMID:12543123, PMID:16051357]
comment: Note that a heavy chain immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgNAR is found in serum of cartilaginous fish as a heavy chain dimer without immunoglobulin light chains. Note that HCab is found in camels as a heavy chain dimer without immunoglobulin light chains.
synonym: "HCab" NARROW [GOC:add]
synonym: "Ig NAR immunoglobulin complex" NARROW [GOC:add]
synonym: "IgNAR antibody" NARROW [GOC:add]
synonym: "IgNAR immunoglobulin complex" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex

[Term]
id: GO:0071763
name: nuclear membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah]
synonym: "nuclear membrane organisation" EXACT [GOC:mah]
synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0006998 ! nuclear envelope organization

[Term]
id: GO:0071764
name: nuclear outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah]
synonym: "nuclear outer membrane organisation" EXACT [GOC:mah]
synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071763 ! nuclear membrane organization

[Term]
id: GO:0071765
name: nuclear inner membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane." [GOC:mah]
synonym: "nuclear inner membrane organisation" EXACT [GOC:mah]
synonym: "nuclear inner membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071763 ! nuclear membrane organization

[Term]
id: GO:0071766
name: Actinobacterium-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface." [GOC:mah, PMID:15653820, PMID:3149973]
is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0071767
name: mycolic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, PMID:15653820]
synonym: "mycolate metabolic process" EXACT [GOC:mah]
synonym: "mycolic acid metabolism" EXACT [GOC:mah]
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0071768
name: mycolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, MetaCyc:PWYG-321, PMID:15653820]
synonym: "mycolate biosynthetic process" EXACT [GOC:mah]
synonym: "mycolic acid anabolism" EXACT [GOC:mah]
synonym: "mycolic acid biosynthesis" EXACT [GOC:mah]
synonym: "mycolic acid formation" EXACT [GOC:mah]
synonym: "mycolic acid synthesis" EXACT [GOC:mah]
xref: MetaCyc:PWYG-321
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0071767 ! mycolic acid metabolic process
relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis

[Term]
id: GO:0071769
name: mycolate cell wall layer assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer." [GOC:mah, MetaCyc:PWY-6397, PMID:15653820, PMID:3149973]
synonym: "mycolate cell wall layer biogenesis" RELATED [GOC:mah]
xref: MetaCyc:PWY-6397
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis

[Term]
id: GO:0071770
name: DIM/DIP cell wall layer assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall." [GOC:mah, GOC:pr, PMID:15653820, PMID:3149973]
synonym: "DIM cell wall layer assembly" EXACT [GOC:mah]
synonym: "DIM/DIP cell wall layer biogenesis" RELATED [GOC:mah]
synonym: "PDIM cell wall layer assembly" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis

[Term]
id: GO:0071771
name: aldehyde oxygenase (deformylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain fatty aldehyde + H+ + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP+." [PMID:6593720, PMID:8718622, RHEA:21440]
synonym: "aldehyde decarbonylase activity" EXACT []
synonym: "decarbonylase activity" EXACT [GOC:kad, GOC:mah]
xref: EC:4.1.99.5
xref: MetaCyc:RXN-13262
xref: RHEA:21440
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0071772
name: response to BMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]
synonym: "response to BMP stimulus" EXACT [GOC:dos]
synonym: "response to bone morphogenetic protein stimulus" EXACT [GOC:mah]
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:0071773
name: cellular response to BMP stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]
synonym: "cellular response to bone morphogenetic protein stimulus" EXACT [GOC:mah]
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071772 ! response to BMP

[Term]
id: GO:0071774
name: response to fibroblast growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus." [GOC:mah]
synonym: "response to FGF stimulus" EXACT [GOC:mah]
synonym: "response to fibroblast growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:0071778
name: obsolete WINAC complex
namespace: cellular_component
def: "OBSOLETE. A SWI/SNF-type complex that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF), and mediates the recruitment of unliganded VDR to VDR target sites in promoters. The WINAC complex contains at least 13 subunits, including WSTF, several SWI/SNF components, and DNA replication-related factors." [GOC:BHF, PMID:12837248]
comment: This term was made obsolete because the paper describing the characterization of this complex, which was used to create this term, has been retracted.
synonym: "WINAC complex" EXACT []
is_obsolete: true

[Term]
id: GO:0071781
name: endoplasmic reticulum cisternal network
namespace: cellular_component
def: "A subcompartment of the endoplasmic reticulum consisting of flattened, disc-shaped domains known as cisternae. These are typically found close to the nucleus and are generally more prominent in secretory cells." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "ER cisternal network" EXACT [GOC:mah]
is_a: GO:0098827 ! endoplasmic reticulum subcompartment

[Term]
id: GO:0071782
name: endoplasmic reticulum tubular network
namespace: cellular_component
def: "A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "ER tubular network" EXACT [GOC:mah]
is_a: GO:0098827 ! endoplasmic reticulum subcompartment

[Term]
id: GO:0071783
name: endoplasmic reticulum cisternal network organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum cisternal network organisation" EXACT [GOC:mah]
synonym: "ER cisternal network organisation" EXACT [GOC:mah]
synonym: "ER cisternal network organization" EXACT [GOC:mah]
is_a: GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0071784
name: endoplasmic reticulum cisternal network assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum cisternal network formation" EXACT [GOC:mah]
synonym: "ER cisternal network assembly" EXACT [GOC:mah]
synonym: "ER cisternal network formation" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization

[Term]
id: GO:0071785
name: endoplasmic reticulum cisternal network maintenance
namespace: biological_process
def: "The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336]
synonym: "ER cisternal network maintenance" EXACT [GOC:mah]
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization

[Term]
id: GO:0071786
name: endoplasmic reticulum tubular network organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum tubular network organisation" EXACT [GOC:mah]
synonym: "ER tubular network organisation" EXACT [GOC:mah]
synonym: "ER tubular network organization" EXACT [GOC:mah]
is_a: GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0071787
name: endoplasmic reticulum tubular network formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, GOC:vw, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum tubular network assembly" EXACT []
synonym: "ER tubular network assembly" EXACT [GOC:mah]
synonym: "ER tubular network formation" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0071786 ! endoplasmic reticulum tubular network organization

[Term]
id: GO:0071788
name: endoplasmic reticulum tubular network maintenance
namespace: biological_process
def: "The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336]
synonym: "ER tubular network maintenance" EXACT [GOC:mah]
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0071786 ! endoplasmic reticulum tubular network organization

[Term]
id: GO:0071791
name: chemokine (C-C motif) ligand 5 binding
namespace: molecular_function
def: "Binding to chemokine (C-C motif) ligand 5." [GOC:add, GOC:amm]
synonym: "CCL5 binding" EXACT [GOC:add, GOC:amm]
synonym: "RANTES binding" EXACT [GOC:bf]
synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted binding" EXACT [GOC:add]
is_a: GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0071792
name: bacillithiol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541]
synonym: "bacillithiol metabolism" EXACT [GOC:mah]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0071793
name: bacillithiol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541]
synonym: "bacillithiol anabolism" EXACT [GOC:mah]
synonym: "bacillithiol biosynthesis" EXACT [GOC:mah]
synonym: "bacillithiol formation" EXACT [GOC:mah]
synonym: "bacillithiol synthesis" EXACT [GOC:mah]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0071792 ! bacillithiol metabolic process

[Term]
id: GO:0071794
name: CAP-Gly domain binding
namespace: molecular_function
def: "Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets." [GOC:mah, InterPro:IPR000938]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071795
name: K11-linked polyubiquitin modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein." [GOC:sp, PMID:18775313]
is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding

[Term]
id: GO:0071796
name: K6-linked polyubiquitin modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein." [GOC:sp, PMID:17525341, PMID:20351172]
is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding

[Term]
id: GO:0071797
name: LUBAC complex
namespace: cellular_component
def: "A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180]
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:0071798
name: response to prostaglandin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl]
synonym: "response to prostaglandin D stimulus" EXACT [GOC:dos]
is_a: GO:0034694 ! response to prostaglandin
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0071799
name: cellular response to prostaglandin D stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl]
is_a: GO:0071379 ! cellular response to prostaglandin stimulus
is_a: GO:0071798 ! response to prostaglandin D
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0071800
name: podosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [GOC:mah, GOC:sl]
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:0071801
name: regulation of podosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of podosome assembly." [GOC:mah, GOC:sl]
comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0071800 ! podosome assembly

[Term]
id: GO:0071802
name: negative regulation of podosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of podosome assembly." [GOC:mah, GOC:sl]
synonym: "down regulation of podosome assembly" EXACT [GOC:mah]
synonym: "down-regulation of podosome assembly" EXACT [GOC:mah]
synonym: "downregulation of podosome assembly" EXACT [GOC:mah]
synonym: "inhibition of podosome assembly" NARROW [GOC:mah]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0071801 ! regulation of podosome assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0071800 ! podosome assembly

[Term]
id: GO:0071803
name: positive regulation of podosome assembly
namespace: biological_process
def: "Any process that activates or increases the rate or extent of podosome assembly." [GOC:mah, GOC:sl]
synonym: "activation of podosome assembly" NARROW [GOC:mah]
synonym: "stimulation of podosome assembly" NARROW [GOC:mah]
synonym: "up regulation of podosome assembly" EXACT [GOC:mah]
synonym: "up-regulation of podosome assembly" EXACT [GOC:mah]
synonym: "upregulation of podosome assembly" EXACT [GOC:mah]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0071801 ! regulation of podosome assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0071800 ! podosome assembly

[Term]
id: GO:0071805
name: potassium ion transmembrane transport
namespace: biological_process
alt_id: GO:0010163
def: "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "high affinity potassium ion import" NARROW []
synonym: "high affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb]
synonym: "high-affinity potassium ion import" NARROW []
synonym: "high-affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb]
synonym: "potassium ion membrane transport" EXACT []
is_a: GO:0006813 ! potassium ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0071806
name: protein transmembrane transport
namespace: biological_process
def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "protein membrane transport" EXACT []
is_a: GO:0015031 ! protein transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0071807
name: replication fork arrest involved in DNA replication termination
namespace: biological_process
def: "A replication fork arrest process that contributes to the termination of DNA replication." [GOC:mah, PMID:17347517, PMID:20797631]
is_a: GO:0043111 ! replication fork arrest
relationship: part_of GO:0006274 ! DNA replication termination

[Term]
id: GO:0071808
name: satellite fibril
namespace: cellular_component
def: "An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section)." [GOC:mah, GOC:sl, PMID:20108326]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0071809
name: regulation of fever generation by regulation of prostaglandin biosynthesis
namespace: biological_process
def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:0031620 ! regulation of fever generation
relationship: regulates GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process

[Term]
id: GO:0071810
name: regulation of fever generation by regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031620 ! regulation of fever generation
is_a: GO:0032306 ! regulation of prostaglandin secretion
relationship: regulates GO:0100009 ! regulation of fever generation by prostaglandin secretion

[Term]
id: GO:0071811
name: positive regulation of fever generation by positive regulation of prostaglandin biosynthesis
namespace: biological_process
def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031394 ! positive regulation of prostaglandin biosynthetic process
is_a: GO:0031622 ! positive regulation of fever generation

[Term]
id: GO:0071812
name: positive regulation of fever generation by positive regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031622 ! positive regulation of fever generation
is_a: GO:0032308 ! positive regulation of prostaglandin secretion

[Term]
id: GO:0071813
name: lipoprotein particle binding
namespace: molecular_function
def: "Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:BHF, GOC:mah]
synonym: "lipoprotein binding" RELATED [GOC:mah]
synonym: "plasma lipoprotein binding" RELATED [GOC:mah]
synonym: "plasma lipoprotein particle binding" EXACT [GOC:mah]
is_a: GO:0071814 ! protein-lipid complex binding

[Term]
id: GO:0071814
name: protein-lipid complex binding
namespace: molecular_function
def: "Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules." [GOC:BHF, GOC:mah]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0071815
name: intermediate-density lipoprotein particle binding
namespace: molecular_function
def: "Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm." [GOC:BHF, GOC:mah]
synonym: "IDL binding" EXACT [GOC:BHF]
synonym: "intermediate-density lipoprotein binding" EXACT [GOC:dph]
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0071816
name: tail-anchored membrane protein insertion into ER membrane
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]
synonym: "protein insertion of tail-anchored membrane proteins into ER membrane" EXACT [GOC:sp]
synonym: "tail-anchored membrane protein insertion into endoplasmic reticulum membrane" EXACT [GOC:mah]
synonym: "type II transmembrane protein insertion into ER membrane" EXACT [GOC:mah, GOC:sp]
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0071817
name: MMXD complex
namespace: cellular_component
def: "A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation." [GOC:sp, PMID:20797633]
synonym: "MMS19-MIP18-XPD complex" EXACT [GOC:sp, PMID:20797633]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0071818
name: BAT3 complex
namespace: cellular_component
def: "A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]
synonym: "Bag6 complex" EXACT [PMID:21636303]
synonym: "BAG6-UBL4A-TRC35 complex" EXACT [PMID:21636303]
synonym: "BAT3-TRC35-UBL4A complex" RELATED [PMID:20676083]
is_a: GO:0072379 ! ER membrane insertion complex

[Term]
id: GO:0071819
name: DUBm complex
namespace: cellular_component
def: "A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473]
synonym: "deubiquitinating module" EXACT [GOC:jp, PMID:20395473]
synonym: "deubiquitination module" EXACT [PMID:19226466]
synonym: "SAGA DUBm complex" NARROW [GOC:jp]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071820
name: N-box binding
namespace: molecular_function
def: "Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses." [GOC:yaf, PMID:11498047]
synonym: "N box binding" EXACT [GOC:mah]
synonym: "N-box promoter binding" EXACT [GOC:mah]
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0071821
name: FANCM-MHF complex
namespace: cellular_component
def: "A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes." [GOC:mah, GOC:vw, PMID:20347428]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0071823
name: protein-carbohydrate complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex." [GOC:mah]
synonym: "protein-carbohydrate complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0071824
name: protein-DNA complex organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah]
synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah]
synonym: "protein-DNA complex subunit organisation" EXACT [GOC:mah]
synonym: "protein-DNA complex subunit organization" EXACT []
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0071825
name: protein-lipid complex organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex." [GOC:mah]
synonym: "protein-lipid complex subunit organisation" EXACT [GOC:mah]
synonym: "protein-lipid complex subunit organization" EXACT []
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0071826
name: protein-RNA complex organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah]
synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex subunit organization" EXACT []
synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah]
is_a: GO:0043933 ! protein-containing complex organization

[Term]
id: GO:0071827
name: plasma lipoprotein particle organization
namespace: biological_process
def: "A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins." [GOC:BHF, GOC:mah]
synonym: "plasma lipoprotein particle organisation" EXACT [GOC:mah]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0071825 ! protein-lipid complex organization

[Term]
id: GO:0071828
name: apolipoprotein E recycling
namespace: biological_process
def: "The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle." [GOC:BHF, PMID:16373604]
synonym: "APOE recycling" EXACT [GOC:BHF]
is_a: GO:0015031 ! protein transport
relationship: part_of GO:0034380 ! high-density lipoprotein particle assembly
relationship: part_of GO:0034382 ! chylomicron remnant clearance

[Term]
id: GO:0071829
name: plasma lipoprotein particle disassembly
namespace: biological_process
def: "The disaggregation of a plasma lipoprotein particle into its constituent components." [GOC:mah]
is_a: GO:0032987 ! protein-lipid complex disassembly
is_a: GO:0071827 ! plasma lipoprotein particle organization
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels

[Term]
id: GO:0071830
name: triglyceride-rich lipoprotein particle clearance
namespace: biological_process
def: "The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF]
is_a: GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0071831
name: intermediate-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF]
synonym: "IDL clearance" EXACT [GOC:BHF]
is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance

[Term]
id: GO:0071834
name: mating pheromone secretion
namespace: biological_process
def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction." [GOC:mah]
synonym: "mating-type pheromone secretion" EXACT [GOC:vw]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0071835
name: mating pheromone secretion involved in regulation of conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0071832
def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that regulates the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah]
synonym: "mating pheromone secretion involved in regulation of conjugation" RELATED []
synonym: "mating-type pheromone secretion involved in conjugation" EXACT [GOC:mah, GOC:vw]
synonym: "peptide pheromone export involved in regulation of conjugation" BROAD []
is_a: GO:0071834 ! mating pheromone secretion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0071836
name: nectar secretion
namespace: biological_process
def: "The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins." [GOC:kad, PMID:19861655]
synonym: "nectar production" RELATED [GOC:kad]
is_a: GO:0046903 ! secretion

[Term]
id: GO:0071837
name: HMG box domain binding
namespace: molecular_function
def: "Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin." [GOC:yaf, InterPro:IPR009071, PMID:18445004]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071838
name: cell proliferation in bone marrow
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141]
synonym: "bone marrow cell proliferation" EXACT [GOC:yaf]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0071839
name: apoptotic process in bone marrow cell
namespace: biological_process
def: "The apoptotic process in cells in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, PMID:17063141]
synonym: "apoptosis in bone marrow" NARROW []
synonym: "bone marrow cell apoptosis" EXACT [GOC:yaf]
synonym: "bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "killing of bone marrow cells" EXACT [GOC:mah]
synonym: "programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah]
synonym: "programmed cell death, bone marrow cells" EXACT [GOC:mah]
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0071840
name: cellular component organization or biogenesis
namespace: biological_process
alt_id: GO:0071841
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular component organization or biogenesis at cellular level" EXACT []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0071846
name: actin filament debranching
namespace: biological_process
def: "An actin filament severing process that results in the removal of actin filament branches specifically at the branch points." [GOC:jh, GOC:mah, PMID:20362448]
is_a: GO:0051014 ! actin filament severing

[Term]
id: GO:0071847
name: obsolete TNFSF11-mediated signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301]
comment: This term was obsoleted because it represents a specific ligand of the tumor necrosis factor-mediated signaling pathway ; GO:0033209.
synonym: "RANKL-mediated signaling pathway" EXACT [GOC:BHF]
synonym: "receptor activator of nuclear factor kappa-B ligand signaling pathway" EXACT [Wikipedia:RANKL]
synonym: "TNF-related activation-induced cytokine-mediated signaling pathway" EXACT [Wikipedia:RANKL]
synonym: "TNFSF11-mediated signalling pathway" EXACT [GOC:mah]
synonym: "tumor necrosis factor superfamily member 11-mediated signaling pathway" EXACT [Wikipedia:RANKL]
is_obsolete: true
replaced_by: GO:0033209

[Term]
id: GO:0071848
name: obsolete positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
namespace: biological_process
def: "OBSOLETE. Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade." [GOC:BHF, PMID:18606301]
comment: This term was obsoleted because it represents specific steps in the tumor necrosis factor-mediated signaling pathway ; GO:0033209.
synonym: "positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling" EXACT [GOC:BHF]
synonym: "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0033209

[Term]
id: GO:0071849
name: obsolete G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw]
comment: This term was obsoleted because it does not represent a specific process.
is_obsolete: true

[Term]
id: GO:0071851
name: obsolete mitotic G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. The process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw]
comment: This term was obsoleted because it does not represent a specific process.
synonym: "G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:vw]
is_obsolete: true

[Term]
id: GO:0071852
name: fungal-type cell wall organization or biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall." [GOC:mah]
synonym: "fungal-type cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0071853
name: fungal-type cell wall disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a fungal-type cell wall." [GOC:mah]
is_a: GO:0031505 ! fungal-type cell wall organization
is_a: GO:0044277 ! cell wall disassembly

[Term]
id: GO:0071854
name: cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly
namespace: biological_process
def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall." [GOC:mah]
is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly
relationship: part_of GO:0071853 ! fungal-type cell wall disassembly

[Term]
id: GO:0071855
name: neuropeptide receptor binding
namespace: molecular_function
def: "Binding to a neuropeptide receptor." [GOC:kmv, GOC:mah]
is_a: GO:0001664 ! G protein-coupled receptor binding

[Term]
id: GO:0071857
name: beta-endorphin receptor binding
namespace: molecular_function
def: "Binding to a beta-endorphin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0071858
name: corazonin receptor binding
namespace: molecular_function
def: "Binding to a corazonin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0071859
name: neuropeptide F receptor binding
namespace: molecular_function
def: "Binding to a neuropeptide F receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0071860
name: proctolin receptor binding
namespace: molecular_function
def: "Binding to a proctolin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0071861
name: tachykinin receptor binding
namespace: molecular_function
def: "Binding to a tachykinin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0071863
name: regulation of cell proliferation in bone marrow
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141]
synonym: "regulation of bone marrow cell proliferation" EXACT [GOC:yaf]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0071838 ! cell proliferation in bone marrow

[Term]
id: GO:0071864
name: positive regulation of cell proliferation in bone marrow
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141]
synonym: "activation of cell proliferation in bone marrow" NARROW [GOC:mah]
synonym: "positive regulation of bone marrow cell proliferation" EXACT [GOC:yaf]
synonym: "stimulation of cell proliferation in bone marrow" NARROW [GOC:mah]
synonym: "up regulation of cell proliferation in bone marrow" EXACT [GOC:mah]
synonym: "up-regulation of cell proliferation in bone marrow" EXACT [GOC:mah]
synonym: "upregulation of cell proliferation in bone marrow" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0071863 ! regulation of cell proliferation in bone marrow
relationship: positively_regulates GO:0071838 ! cell proliferation in bone marrow

[Term]
id: GO:0071865
name: regulation of apoptotic process in bone marrow cell
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141]
synonym: "regulation of apoptosis in bone marrow" NARROW []
synonym: "regulation of apoptotic process in bone marrow" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0071839 ! apoptotic process in bone marrow cell

[Term]
id: GO:0071866
name: negative regulation of apoptotic process in bone marrow cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141]
synonym: "down regulation of apoptosis in bone marrow" EXACT [GOC:mah]
synonym: "down-regulation of apoptosis in bone marrow" EXACT [GOC:mah]
synonym: "downregulation of apoptosis in bone marrow" EXACT [GOC:mah]
synonym: "inhibition of apoptosis in bone marrow" NARROW [GOC:mah]
synonym: "negative regulation of apoptosis in bone marrow" NARROW []
synonym: "negative regulation of apoptotic process in bone marrow" EXACT []
synonym: "negative regulation of bone marrow cell apoptosis" EXACT [GOC:mah, GOC:yaf]
synonym: "negative regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "negative regulation of killing of bone marrow cells" EXACT [GOC:mah]
synonym: "negative regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah]
synonym: "negative regulation of programmed cell death, bone marrow cells" EXACT [GOC:mah]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0071865 ! regulation of apoptotic process in bone marrow cell
relationship: negatively_regulates GO:0071839 ! apoptotic process in bone marrow cell

[Term]
id: GO:0071867
name: response to monoamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah]
synonym: "response to monoamine stimulus" EXACT [GOC:dos]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0071868
name: cellular response to monoamine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah]
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0071869
name: response to catecholamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah]
synonym: "response to catecholamine stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0071870
name: cellular response to catecholamine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071868 ! cellular response to monoamine stimulus
is_a: GO:0071869 ! response to catecholamine
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0071871
name: response to epinephrine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "response to adrenaline stimulus" EXACT [GOC:mah]
synonym: "response to epinephrine stimulus" EXACT [GOC:dos]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0071872
name: cellular response to epinephrine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "cellular response to adrenaline stimulus" EXACT [GOC:mah]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0071871 ! response to epinephrine

[Term]
id: GO:0071873
name: response to norepinephrine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "response to noradrenaline stimulus" EXACT [GOC:mah]
synonym: "response to norepinephrine stimulus" EXACT [GOC:dos]
is_a: GO:0071869 ! response to catecholamine

[Term]
id: GO:0071874
name: cellular response to norepinephrine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:0071873 ! response to norepinephrine

[Term]
id: GO:0071875
name: adrenergic receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF]
synonym: "adrenergic receptor signalling pathway" EXACT [GOC:mah]
synonym: "adrenoceptor signaling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0071876
name: obsolete initiation of adrenergic receptor signal transduction
namespace: biological_process
def: "OBSOLETE. A process of signal initiation in which epinephrine or norepinephrine causes activation of an adrenergic receptor." [GOC:BHF, GOC:mah]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "initiation of adrenergic receptor signal transduction" EXACT []
is_obsolete: true
consider: GO:0004935
consider: GO:0005179
consider: GO:0071872
consider: GO:0071874
consider: GO:0071875

[Term]
id: GO:0071877
name: regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah]
synonym: "regulation of adrenergic receptor signaling pathway" EXACT []
synonym: "regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway

[Term]
id: GO:0071878
name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah]
synonym: "negative regulation of adrenergic receptor signaling pathway" EXACT []
synonym: "negative regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0106072 ! negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
relationship: negatively_regulates GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway

[Term]
id: GO:0071879
name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the adenylate cyclase-activating adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah]
synonym: "positive regulation of adrenergic receptor signaling pathway" BROAD []
synonym: "positive regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
relationship: positively_regulates GO:0071875 ! adrenergic receptor signaling pathway

[Term]
id: GO:0071880
name: adenylate cyclase-activating adrenergic receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "activation of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of adenylate cyclase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah]
synonym: "adrenergic receptor, adenylate cyclase activating pathway" EXACT [GOC:mah]
synonym: "adrenergic receptor, adenylyl cyclase activating pathway" EXACT [GOC:mah]
is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway
is_a: GO:0071875 ! adrenergic receptor signaling pathway

[Term]
id: GO:0071881
name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "adrenergic receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:mah]
synonym: "adrenergic receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:mah]
synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway" RELATED [GOC:mah]
is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
is_a: GO:0071875 ! adrenergic receptor signaling pathway

[Term]
id: GO:0071882
name: phospholipase C-activating adrenergic receptor signaling pathway
namespace: biological_process
def: "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "activation of phospholipase C activity by adrenergic receptor signaling pathway" RELATED [GOC:bf]
synonym: "activation of phospholipase C activity by adrenergic receptor signalling pathway" RELATED [GOC:mah]
synonym: "adrenergic receptor, phospholipase C activating pathway" RELATED [GOC:mah]
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0071875 ! adrenergic receptor signaling pathway

[Term]
id: GO:0071883
name: MAPK-activating adrenergic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade." [GOC:BHF, GOC:mah]
synonym: "activation of MAP kinase activity by adrenergic receptor signaling pathway" EXACT [GOC:mah]
synonym: "activation of MAP kinase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah]
synonym: "activation of MAPK activity by adrenergic receptor signaling pathway" EXACT []
synonym: "activation of MAPK activity by adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0071875 ! adrenergic receptor signaling pathway

[Term]
id: GO:0071885
name: N-terminal protein N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588]
synonym: "X-Pro-Lys N-terminal methyltransferase" NARROW [GOC:rn]
xref: EC:2.1.1.244
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0071886
name: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
namespace: molecular_function
def: "Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug." [GOC:yaf, PMID:19057895]
synonym: "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding" EXACT [CHEBI:100436]
synonym: "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding" EXACT [PMID:19057895]
synonym: "4-iodo-2,5-dimethoxyphenylisopropylamine binding" EXACT [PubChem_Compound:1229]
is_a: GO:0043176 ! amine binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0071887
name: leukocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "leukocyte apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0071888
name: macrophage apoptotic process
namespace: biological_process
def: "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues." [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation-induced cell death" RELATED [GOC:yaf]
synonym: "AICD" RELATED [GOC:yaf]
synonym: "macrophage apoptosis" NARROW []
is_a: GO:0006925 ! inflammatory cell apoptotic process
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process

[Term]
id: GO:0071889
name: 14-3-3 protein binding
namespace: molecular_function
def: "Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0071890
name: bicarbonate binding
namespace: molecular_function
def: "Binding to bicarbonate ions (CHO3-)." [GOC:curators]
synonym: "CHO3- ion binding binding" EXACT []
synonym: "hydrogencarbonate binding" EXACT [CHEBI:17544]
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0071891
name: obsolete N-terminal peptidyl-proline dimethylation involved in translation
namespace: biological_process
def: "OBSOLETE. An N-terminal peptidyl-proline dimethylation process that contributes to translation." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0071892
name: thrombocyte activation
namespace: biological_process
def: "A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals." [GOC:lb, GOC:mah, PMID:10606877, PMID:15634265, PMID:20180901]
synonym: "blood coagulation, thrombocyte activation" EXACT [GOC:mah]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0007596 ! blood coagulation

[Term]
id: GO:0071893
name: obsolete BMP signaling pathway involved in nephric duct formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to nephric duct formation." [GOC:mah, GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "BMP signalling pathway involved in nephric duct formation" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0072179

[Term]
id: GO:0071894
name: obsolete histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "OBSOLETE. A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals." [GOC:mah, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "budding yeast H2B K123 ubiquitination" NARROW [GOC:vw]
synonym: "fission yeast H2B K119 ubiquitination" NARROW [GOC:vw]
synonym: "mammalian H2B K120 ubiquitination" NARROW [GOC:vw]
is_obsolete: true

[Term]
id: GO:0071895
name: odontoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin." [GOC:sl, PMID:20425127]
is_a: GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0071896
name: protein localization to adherens junction
namespace: biological_process
alt_id: GO:1904696
def: "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237]
synonym: "protein localisation in adherens junction" EXACT []
synonym: "protein localisation in cell-cell adherens junction" EXACT []
synonym: "protein localisation to adherens junction" EXACT [GOC:mah]
synonym: "protein localisation to cell-cell adherens junction" EXACT []
synonym: "protein localization in adherens junction" EXACT []
synonym: "protein localization in cell-cell adherens junction" EXACT []
synonym: "protein localization to cell-cell adherens junction" EXACT []
is_a: GO:0150105 ! protein localization to cell-cell junction

[Term]
id: GO:0071897
name: DNA biosynthetic process
namespace: biological_process
def: "The biosynthetic process resulting in the formation of DNA." [GOC:mah]
synonym: "DNA anabolism" EXACT [GOC:mah]
synonym: "DNA biosynthesis" EXACT [GOC:mah]
synonym: "DNA formation" EXACT [GOC:mah]
synonym: "DNA synthesis" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0141187 ! nucleic acid biosynthetic process

[Term]
id: GO:0071898
name: obsolete regulation of estrogen receptor binding
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of estrogen receptor binding, interacting selectively with a an estrogen receptor." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0071899
name: obsolete negative regulation of estrogen receptor binding
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0071900
name: regulation of protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0071901
name: negative regulation of protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:0071902
name: positive regulation of protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0045860 ! positive regulation of protein kinase activity
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:0071903
name: obsolete protein N-linked N-acetylglucosaminylation via asparagine
namespace: biological_process
def: "OBSOLETE. A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0151]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid N-linked N-acetylglucosaminylation via asparagine" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0071904
name: obsolete protein N-linked N-acetylgalactosaminylation via asparagine
namespace: biological_process
def: "OBSOLETE. A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0420]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid N-linked N-acetylgalactosaminylation via asparagine" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0071905
name: obsolete protein N-linked glucosylation via asparagine
namespace: biological_process
def: "OBSOLETE. A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0421]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid N-linked glucosylation via asparagine" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0071906
name: CRD domain binding
namespace: molecular_function
def: "Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins." [GOC:yaf, PMID:19460168]
synonym: "context dependent regulatory domain binding" EXACT [GOC:mah]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071907
name: determination of digestive tract left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs]
synonym: "determination of gut left/right asymmetry" EXACT [GOC:cvs]
synonym: "determination of left/right asymmetry of the digestive tract" EXACT [GOC:cvs]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0071908
name: determination of intestine left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism." [GOC:cvs]
is_a: GO:0071907 ! determination of digestive tract left/right asymmetry

[Term]
id: GO:0071909
name: determination of stomach left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism." [GOC:cvs]
is_a: GO:0071907 ! determination of digestive tract left/right asymmetry
relationship: part_of GO:0062094 ! stomach development

[Term]
id: GO:0071910
name: determination of liver left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the liver with respect to the left and right halves of the organism." [GOC:cvs]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0071911
name: synchronous neurotransmitter secretion
namespace: biological_process
def: "Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933]
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0071912
name: asynchronous neurotransmitter secretion
namespace: biological_process
def: "Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933]
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0071913
name: citrate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mah, GOC:mtg_transport, GOC:vw]
synonym: "citrate carrier activity" EXACT [GOC:mah]
is_a: GO:0005371 ! tricarboxylate secondary active transmembrane transporter activity
is_a: GO:0015137 ! citrate transmembrane transporter activity

[Term]
id: GO:0071914
name: prominosome
namespace: cellular_component
def: "An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known." [GOC:vesicles, PMID:15976444, PMID:17109118, PMID:17283184]
synonym: "prominin-containing extracellular membrane vesicle" EXACT []
is_a: GO:1903561 ! extracellular vesicle

[Term]
id: GO:0071915
name: obsolete protein-lysine lysylation
namespace: biological_process
def: "OBSOLETE. The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:imk, GOC:jsg, PMID:20729861]
comment: This term was obsoleted because it represents a molecular function.
synonym: "protein amino acid lysylation" EXACT [GOC:imk]
is_obsolete: true

[Term]
id: GO:0071916
name: dipeptide transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0042936
def: "Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:mah]
synonym: "dipeptide transporter activity" RELATED []
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity

[Term]
id: GO:0071917
name: triose-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a triose phosphate from one side of a membrane to the other." [GOC:mah, GOC:vw]
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:0071918
name: urea transmembrane transport
namespace: biological_process
def: "The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "urea membrane transport" EXACT []
is_a: GO:0015840 ! urea transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0071919
name: G-quadruplex DNA formation
namespace: biological_process
def: "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature." [GOC:sre, PMID:20098422]
synonym: "G quadruplex DNA formation" EXACT [GOC:mah]
synonym: "G quartet DNA formation" EXACT [GOC:mah]
synonym: "G-quartet DNA formation" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0071920
name: cleavage body
namespace: cellular_component
def: "A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing." [PMID:10564273, PMID:11598190, PMID:8654386]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0071921
name: obsolete cohesin loading
namespace: biological_process
def: "OBSOLETE. The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA." [GOC:dph, GOC:mah, GOC:vw, PMID:10882066, PMID:17113138, PMID:26687354]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "cohesin association with chromatin" EXACT [GOC:lb]
synonym: "cohesin localisation to chromatin" EXACT [GOC:mah]
synonym: "cohesin localization to chromatin" EXACT [GOC:vw]
is_obsolete: true

[Term]
id: GO:0071922
name: obsolete regulation of cohesin loading
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
synonym: "regulation of cohesin association with chromatin" EXACT [GOC:lb]
synonym: "regulation of cohesin localisation to chromatin" EXACT [GOC:mah]
synonym: "regulation of cohesin localization to chromatin" EXACT [GOC:vw]
is_obsolete: true

[Term]
id: GO:0071923
name: obsolete negative regulation of cohesin loading
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
synonym: "negative regulation of cohesin association with chromatin" EXACT [GOC:lb]
synonym: "negative regulation of cohesin localisation to chromatin" EXACT [GOC:mah]
synonym: "negative regulation of cohesin localization to chromatin" RELATED [GOC:vw]
is_obsolete: true

[Term]
id: GO:0071924
name: chemokine (C-C motif) ligand 22 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:18832724]
subset: gocheck_do_not_annotate
synonym: "C-C motif chemokine 22 production" EXACT [GOC:mah]
synonym: "CCL-22 production" EXACT [GOC:mah]
synonym: "CCL22 production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071925
name: thymic stromal lymphopoietin production
namespace: biological_process
def: "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:17129180]
subset: gocheck_do_not_annotate
synonym: "TSLP production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071926
name: endocannabinoid signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol." [GOC:bf, GOC:mah, PMID:15550444]
synonym: "endocannabinoid signalling pathway" EXACT [GOC:mah]
is_a: GO:0038171 ! cannabinoid signaling pathway

[Term]
id: GO:0071927
name: octopamine signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor." [GOC:mah, PMID:15355245]
synonym: "octopamine signalling pathway" EXACT [GOC:mah]
is_a: GO:0007211 ! octopamine or tyramine signaling pathway

[Term]
id: GO:0071928
name: tyramine signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor." [GOC:mah, PMID:15355245]
synonym: "tyramine signalling pathway" EXACT [GOC:mah]
is_a: GO:0007211 ! octopamine or tyramine signaling pathway

[Term]
id: GO:0071929
name: alpha-tubulin acetylation
namespace: biological_process
def: "The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050]
subset: gocheck_obsoletion_candidate
is_a: GO:0018393 ! internal peptidyl-lysine acetylation

[Term]
id: GO:0071930
name: obsolete negative regulation of transcription involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0000082
consider: GO:0000122

[Term]
id: GO:0071931
name: obsolete positive regulation of transcription involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0000082
consider: GO:0045944

[Term]
id: GO:0071932
name: replication fork reversal
namespace: biological_process
def: "Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved." [PMID:19406929]
is_a: GO:0031297 ! replication fork processing

[Term]
id: GO:0071933
name: Arp2/3 complex binding
namespace: molecular_function
def: "Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)." [GOC:mah]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0071934
name: thiamine transmembrane transport
namespace: biological_process
def: "The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "thiamin transmembrane transport" EXACT [GOC:mah]
synonym: "thiamine membrane transport" EXACT []
synonym: "vitamin B1 transmembrane transport" EXACT [GOC:mah]
is_a: GO:0015888 ! thiamine transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport

[Term]
id: GO:0071935
name: octopamine signaling pathway involved in response to food
namespace: biological_process
def: "The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus." [GOC:mah, PMID:19609300]
synonym: "octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:0071927 ! octopamine signaling pathway
relationship: part_of GO:0032094 ! response to food

[Term]
id: GO:0071936
name: obsolete coreceptor activity involved in Wnt signaling pathway
namespace: molecular_function
def: "OBSOLETE. In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway." [GOC:BHF, GOC:mah]
comment: Precomposed term that should be captured as GO-CAMs or extension.
synonym: "coreceptor activity involved in Wnt receptor signaling pathway" EXACT []
synonym: "coreceptor activity involved in Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "coreceptor activity involved in Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "Wnt co-receptor activity" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0071938
name: vitamin A transport
namespace: biological_process
def: "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]
synonym: "vitamin A uptake and transport" RELATED [GOC:rs]
is_a: GO:0046865 ! terpenoid transport
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0071939
name: vitamin A import into cell
namespace: biological_process
def: "The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]
synonym: "vitamin A import" RELATED []
synonym: "vitamin A uptake" EXACT [GOC:mah, GOC:rs]
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0071938 ! vitamin A transport
is_a: GO:0098657 ! import into cell
is_a: GO:0140354 ! lipid import into cell

[Term]
id: GO:0071940
name: fungal-type cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall." [GOC:mah, GOC:vw, PMID:19646873]
synonym: "fungal-type cell wall formation" RELATED [GOC:mah]
is_a: GO:0031505 ! fungal-type cell wall organization
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0071941
name: nitrogen cycle metabolic process
namespace: biological_process
def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
xref: Wikipedia:Nitrogen_cycle
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0071942
name: XPC complex
namespace: cellular_component
def: "A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2." [PMID:11279143, PMID:15964821, PMID:19941824]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0071943
name: Myc-Max complex
namespace: cellular_component
def: "A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max." [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0071944
name: cell periphery
namespace: cellular_component
def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]
subset: goslim_flybase_ribbon
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0071945
name: regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed
namespace: biological_process
def: "A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein." [GOC:cilia, GOC:jl, PMID:20371342]
synonym: "regulation of bacterial-type flagellar cell motility by regulation of motor speed" RELATED []
synonym: "regulation of bacterial-type flagellum cell motility by regulation of motor speed" EXACT []
synonym: "regulation of flagellar cell motility by regulation of motor speed" BROAD []
is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility

[Term]
id: GO:0071946
name: cis-acting DNA replication termination
namespace: biological_process
def: "A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing." [GOC:vw, PMID:20850009]
synonym: "cis acting DNA replication termination" EXACT [GOC:vw]
is_a: GO:0071170 ! site-specific DNA replication termination

[Term]
id: GO:0071947
name: protein deubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism." [GOC:mah]
is_a: GO:0016579 ! protein deubiquitination
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0071948
name: activation-induced B cell apoptotic process
namespace: biological_process
def: "B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death." [GOC:mtg_apoptosis, GOC:tfm, PMID:11032170, PMID:19300454]
synonym: "activated B cell apoptosis" BROAD [GOC:tfm]
synonym: "activation-induced B cell apoptosis" NARROW []
synonym: "activation-induced B-cell apoptosis" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B cells" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B lymphocytes" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B-cells" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B-lymphocytes" EXACT [GOC:tfm]
synonym: "AICD" BROAD [GOC:tfm]
synonym: "antigen-driven apoptosis" BROAD [GOC:tfm]
is_a: GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0071949
name: FAD binding
namespace: molecular_function
def: "Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
synonym: "oxidized flavin adenine dinucleotide binding" EXACT [GOC:mah]
synonym: "oxidized flavine-adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0050660 ! flavin adenine dinucleotide binding

[Term]
id: GO:0071950
name: FADH2 binding
namespace: molecular_function
def: "Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
synonym: "reduced flavin adenine dinucleotide binding" EXACT [GOC:mah]
synonym: "reduced flavine-adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0050660 ! flavin adenine dinucleotide binding

[Term]
id: GO:0071951
name: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet)." [GOC:jsg, PMID:5337045]
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0071952
name: conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA." [GOC:jsg, PMID:17351629, PMID:18559341]
comment: Note that this process has been observed in some archaeal and bacterial species.
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0071953
name: elastic fiber
namespace: cellular_component
def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620]
synonym: "elastic fibre" EXACT [GOC:mah]
synonym: "elastin fiber" EXACT [GOC:BHF]
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0071954
name: chemokine (C-C motif) ligand 11 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9600955]
subset: gocheck_do_not_annotate
synonym: "C-C motif chemokine 11 production" EXACT [GOC:mah]
synonym: "CCL-11 production" EXACT [GOC:mah]
synonym: "CCL11 production" EXACT [GOC:mah]
synonym: "eotaxin production" BROAD [GOC:mah]
synonym: "eotaxin-1 production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071955
name: recycling endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from recycling endosomes to the Golgi." [GOC:lb]
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0071957
name: old mitotic spindle pole body
namespace: cellular_component
def: "The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis." [GOC:mah, GOC:vw, PMID:15132994]
synonym: "old SPB" EXACT [GOC:mah]
is_a: GO:0044732 ! mitotic spindle pole body

[Term]
id: GO:0071958
name: new mitotic spindle pole body
namespace: cellular_component
def: "The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize." [GOC:mah, GOC:vw, PMID:15132994]
synonym: "new SPB" EXACT [GOC:mah]
is_a: GO:0044732 ! mitotic spindle pole body

[Term]
id: GO:0071959
name: maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436]
synonym: "maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:mah]
synonym: "maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:mah]
is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: part_of GO:0071961 ! mitotic sister chromatid cohesion, arms

[Term]
id: GO:0071960
name: maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436]
synonym: "maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
synonym: "maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:mah]
synonym: "maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:mah]
is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: part_of GO:0071962 ! mitotic sister chromatid cohesion, centromeric

[Term]
id: GO:0071961
name: mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis." [GOC:mah]
synonym: "mitotic sister chromatid cohesion along arms" EXACT [GOC:mah]
synonym: "sister chromatid cohesion along arms at mitosis" EXACT [GOC:mah]
is_a: GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0071962
name: mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The cell cycle process in which centromeres of sister chromatids are joined during mitosis." [GOC:mah]
synonym: "centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
synonym: "mitotic sister chromatid cohesion at centromere" EXACT [GOC:mah]
synonym: "sister chromatid cohesion at centromere at mitosis" EXACT [GOC:mah]
is_a: GO:0007064 ! mitotic sister chromatid cohesion
is_a: GO:0070601 ! centromeric sister chromatid cohesion

[Term]
id: GO:0071963
name: establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
is_a: GO:0008360 ! regulation of cell shape

[Term]
id: GO:0071964
name: establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell." [GOC:mah]
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape

[Term]
id: GO:0071965
name: multicellular organismal locomotion
namespace: biological_process
def: "Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another." [GOC:mah]
is_a: GO:0040011 ! locomotion
is_a: GO:0050879 ! multicellular organismal movement

[Term]
id: GO:0071966
name: fungal-type cell wall polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall." [GOC:mah]
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
relationship: part_of GO:0071852 ! fungal-type cell wall organization or biogenesis

[Term]
id: GO:0071967
name: lipopolysaccharide core heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+." [MetaCyc:RXN0-5122]
synonym: "LPS core heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY]
xref: MetaCyc:RXN0-5122
xref: RHEA:29923
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity

[Term]
id: GO:0071968
name: lipid A-core heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+." [MetaCyc:RXN0-5127]
xref: MetaCyc:RXN0-5127
xref: RHEA:30019
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity

[Term]
id: GO:0071969
name: fungal-type cell wall (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of fungi." [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "fungal-type cell wall 1,3-beta-glucan metabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process

[Term]
id: GO:0071970
name: fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls." [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-D-glucan biosynthetic process" EXACT []
synonym: "fungal-type cell wall 1,3-beta-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-glucan synthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process
is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process

[Term]
id: GO:0071971
name: extracellular exosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458]
synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0097734 ! extracellular exosome biogenesis

[Term]
id: GO:0071972
name: peptidoglycan L,D-transpeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine." [MetaCyc:RXN-11349]
xref: MetaCyc:RXN-11349
is_a: GO:0004185 ! serine-type carboxypeptidase activity

[Term]
id: GO:0071973
name: bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:krc, GOC:mah]
subset: goslim_metagenomics
synonym: "bacterial-type flagellar cell motility" RELATED []
synonym: "flagellin-based flagellar cell motility" EXACT [GOC:mah]
is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility

[Term]
id: GO:0071975
name: cell swimming
namespace: biological_process
def: "Cell motility that results in the smooth movement of a cell through a liquid medium." [PMID:18461074]
synonym: "cell swimming motility" EXACT [GOC:mah]
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0071976
name: cell gliding
namespace: biological_process
def: "Cell motility that results in the smooth movement of a cell along a solid surface." [PMID:18461074]
synonym: "cell gliding motility" EXACT [GOC:mah]
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0071977
name: bacterial-type flagellum-dependent swimming motility
namespace: biological_process
def: "Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium." [GOC:cilia, PMID:18461074]
synonym: "bacterial-type flagellar swimming motility" RELATED []
synonym: "bacterial-type flagellum-mediated cell swimming" EXACT [GOC:mah]
is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility
is_a: GO:0071975 ! cell swimming

[Term]
id: GO:0071978
name: bacterial-type flagellum-dependent swarming motility
namespace: biological_process
def: "Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria." [GOC:cilia, PMID:14527279, PMID:18461074]
synonym: "bacterial-type flagellar swarming motility" RELATED []
synonym: "bacterial-type flagellum-mediated cell swarming" EXACT [GOC:mah]
is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility

[Term]
id: GO:0071979
name: cytoskeleton-mediated cell swimming
namespace: biological_process
def: "Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium." [PMID:18461074]
synonym: "cytoskeleton-mediated swimming motility" EXACT [GOC:mah]
is_a: GO:0071975 ! cell swimming

[Term]
id: GO:0071980
name: cell surface adhesin-mediated gliding motility
namespace: biological_process
def: "Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins." [PMID:18461074]
is_a: GO:0071976 ! cell gliding

[Term]
id: GO:0071981
name: exit from diapause
namespace: biological_process
def: "The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah]
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0071982
name: maintenance of diapause
namespace: biological_process
def: "The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah]
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0071983
name: exit from reproductive diapause
namespace: biological_process
def: "The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah]
is_a: GO:0071981 ! exit from diapause

[Term]
id: GO:0071984
name: maintenance of reproductive diapause
namespace: biological_process
def: "The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah]
is_a: GO:0071982 ! maintenance of diapause

[Term]
id: GO:0071985
name: multivesicular body sorting pathway
namespace: biological_process
def: "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0071986
name: Ragulator complex
namespace: cellular_component
alt_id: GO:0034448
alt_id: GO:0034449
def: "A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]
synonym: "EGO complex" RELATED []
synonym: "EGO-GSE complex" RELATED []
synonym: "GSE complex" RELATED []
synonym: "GTPase-containing complex for Gap1p sorting in the endosome" RELATED []
synonym: "MAPKSP1/ROBLD3/C11orf59 complex" EXACT [GOC:mah]
synonym: "Rag GEF" EXACT []
is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0071987
name: WD40-repeat domain binding
namespace: molecular_function
def: "Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain." [GOC:yaf, InterPro:IPR017986]
synonym: "beta-transducin repeat domain binding" EXACT [GOC:yaf]
synonym: "WD domain binding" EXACT [GOC:yaf]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071988
name: protein localization to spindle pole body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the spindle pole body." [GOC:mah]
synonym: "protein localisation to spindle pole body" EXACT [GOC:mah]
is_a: GO:1905508 ! protein localization to microtubule organizing center

[Term]
id: GO:0071989
name: establishment of protein localization to spindle pole body
namespace: biological_process
def: "The directed movement of a protein to a specific location at the spindle pole body." [GOC:mah]
synonym: "establishment of protein localisation to spindle pole body" EXACT [GOC:mah]
is_a: GO:0071988 ! protein localization to spindle pole body
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0071990
name: maintenance of protein location to spindle pole body
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere." [GOC:mah, GOC:vw]
synonym: "maintenance of protein location at spindle pole body" EXACT []
synonym: "maintenance of protein location in spindle pole body" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0072595 ! maintenance of protein localization in organelle
relationship: part_of GO:0051300 ! spindle pole body organization
relationship: part_of GO:0071988 ! protein localization to spindle pole body

[Term]
id: GO:0071993
name: phytochelatin transport
namespace: biological_process
def: "The directed movement of a phytochelatin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
synonym: "cadystin transport" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0071994
name: phytochelatin transmembrane transport
namespace: biological_process
def: "The process in which a phytochelatin is transported across a membrane. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "cadystin transmembrane transport" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "phytochelatin membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071993 ! phytochelatin transport

[Term]
id: GO:0071995
name: phytochelatin import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatins into the vacuole. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
synonym: "cadystin import into vacuole" RELATED [GOC:vw, Wikipedia:Phytochelatin#History]
synonym: "phytochelatin transport into vacuole" EXACT [GOC:vw]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0071994 ! phytochelatin transmembrane transport

[Term]
id: GO:0071996
name: glutathione transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of glutathione into the vacuole across the vacuolar membrane." [GOC:mah]
synonym: "glutathione transport into vacuole" EXACT [GOC:vw]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0034775 ! glutathione transmembrane transport

[Term]
id: GO:0071998
name: ascospore release from ascus
namespace: biological_process
def: "A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mah]
synonym: "ascospore liberation" EXACT [DOI:10.1016/S0953-7562(96)80057-8]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048869 ! cellular developmental process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0071999
name: obsolete extracellular polysaccharide catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures." [GOC:mah, GOC:vw]
comment: The reason for obsoletion is that this term is now redundant with GO:0000272, polysaccharide catabolic process
synonym: "extracellular polysaccharide breakdown" EXACT [GOC:mah]
synonym: "extracellular polysaccharide catabolism" EXACT [GOC:mah]
synonym: "extracellular polysaccharide degradation" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:0000272

[Term]
id: GO:0072000
name: obsolete extracellular polysaccharide catabolic process involved in ascospore release from ascus
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah, GOC:vw]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "ascus catabolic process" RELATED [GOC:vw]
synonym: "ascus endolysis" RELATED [GOC:vw]
synonym: "extracellular polysaccharide breakdown involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "extracellular polysaccharide catabolism involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "extracellular polysaccharide degradation involved in ascospore release from ascus" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072001
name: renal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:6996269]
subset: gocheck_do_not_annotate
synonym: "urinary system development" BROAD [GOC:yaf]
synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463]
is_a: GO:0048731 ! system development

[Term]
id: GO:0072002
name: Malpighian tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0048513 ! animal organ development
is_a: GO:0061326 ! renal tubule development

[Term]
id: GO:0072003
name: kidney rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060993 ! kidney morphogenesis

[Term]
id: GO:0072004
name: kidney field specification
namespace: biological_process
def: "The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop." [GOC:mtg_kidney_jan10]
synonym: "specification of kidney anlage" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010092 ! specification of animal organ identity
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072003 ! kidney rudiment formation

[Term]
id: GO:0072005
name: maintenance of kidney identity
namespace: biological_process
def: "The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
synonym: "maintenance of kidney anlage identity" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048496 ! maintenance of animal organ identity
relationship: part_of GO:0072003 ! kidney rudiment formation

[Term]
id: GO:0072006
name: nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
synonym: "nephrogenesis" RELATED [GOC:rph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072007
name: mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
is_a: GO:1904238 ! pericyte cell differentiation

[Term]
id: GO:0072008
name: glomerular mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0072007 ! mesangial cell differentiation
relationship: part_of GO:0072109 ! glomerular mesangium development

[Term]
id: GO:0072009
name: nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072010
name: glomerular epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0072011
name: glomerular endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0003158 ! endothelium development
is_a: GO:0072010 ! glomerular epithelium development
relationship: part_of GO:0072012 ! glomerulus vasculature development

[Term]
id: GO:0072012
name: glomerulus vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10]
synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0001568 ! blood vessel development
is_a: GO:0061440 ! kidney vasculature development
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0072013
name: glomus development
namespace: biological_process
def: "The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." [GOC:mtg_kidney_jan10, PMID:10572058, PMID:15647339, PMID:9268568, XAO:0000318]
synonym: "pronephric glomus development" EXACT [GOC:mtg_kidney_jan10, PMID:15895368]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0072014
name: proximal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072015
name: podocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "glomerular visceral epithelial cell development" EXACT []
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0072112 ! podocyte differentiation

[Term]
id: GO:0072016
name: glomerular parietal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
synonym: "Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation

[Term]
id: GO:0072017
name: distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072019
name: proximal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072014 ! proximal tubule development

[Term]
id: GO:0072020
name: proximal straight tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GOC:mtg_kidney_jan10]
synonym: "S3 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072014 ! proximal tubule development

[Term]
id: GO:0072021
name: ascending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072070 ! loop of Henle development

[Term]
id: GO:0072022
name: descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072070 ! loop of Henle development

[Term]
id: GO:0072023
name: thick ascending limb development
namespace: biological_process
alt_id: GO:0072026
def: "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "TAL development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072017 ! distal tubule development

[Term]
id: GO:0072024
name: macula densa development
namespace: biological_process
def: "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072051 ! juxtaglomerular apparatus development

[Term]
id: GO:0072025
name: distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072017 ! distal tubule development

[Term]
id: GO:0072027
name: connecting tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct." [GOC:mtg_kidney_jan10]
synonym: "connecting duct development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072028
name: nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072029
name: long nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla." [GOC:mtg_kidney_jan10]
synonym: "juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development

[Term]
id: GO:0072030
name: short nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development

[Term]
id: GO:0072031
name: proximal convoluted tubule segment 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:mtg_kidney_jan10, MA:0002612]
synonym: "S1 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0072019 ! proximal convoluted tubule development

[Term]
id: GO:0072032
name: proximal convoluted tubule segment 2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride." [GOC:mtg_kidney_jan10, MA:0002613]
synonym: "S2 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0072019 ! proximal convoluted tubule development

[Term]
id: GO:0072033
name: renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072077 ! renal vesicle morphogenesis

[Term]
id: GO:0072034
name: renal vesicle induction
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle." [GOC:mtg_kidney_jan10]
synonym: "nephron induction" EXACT [GOC:mtg_kidney_jan10]
synonym: "positive regulation of nephron formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0031128 ! developmental induction
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0072033 ! renal vesicle formation

[Term]
id: GO:0072035
name: pre-tubular aggregate formation
namespace: biological_process
def: "The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10]
synonym: "mesenchymal cell condensation involved in renal vesicle formation" EXACT [GOC:mtg_kidney_jan10]
synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0072033 ! renal vesicle formation

[Term]
id: GO:0072036
name: mesenchymal to epithelial transition involved in renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0060231 ! mesenchymal to epithelial transition
relationship: part_of GO:0072033 ! renal vesicle formation

[Term]
id: GO:0072037
name: mesenchymal stem cell differentiation involved in nephron morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
is_a: GO:0072497 ! mesenchymal stem cell differentiation
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072038
name: mesenchymal stem cell maintenance involved in nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0035019 ! somatic stem cell population maintenance
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072039
name: regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
relationship: regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis

[Term]
id: GO:0072040
name: negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis
is_a: GO:1904673 ! negative regulation of somatic stem cell population maintenance
is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process
relationship: negatively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis

[Term]
id: GO:0072041
name: positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
is_a: GO:1904674 ! positive regulation of somatic stem cell population maintenance
is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process
relationship: positively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis

[Term]
id: GO:0072042
name: regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation
relationship: regulates GO:0072090 ! mesenchymal stem cell proliferation involved in nephron morphogenesis

[Term]
id: GO:0072043
name: regulation of pre-tubular aggregate formation by cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10]
synonym: "regulation of pre-tubular aggregate formation by cell-cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0072035 ! pre-tubular aggregate formation

[Term]
id: GO:0072044
name: collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072045
name: convergent extension involved in nephron morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0060029 ! convergent extension involved in organogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072046
name: establishment of planar polarity involved in nephron morphogenesis
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
synonym: "establishment of planar cell polarity involved in nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10]
is_a: GO:0001736 ! establishment of planar polarity
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072047
name: proximal/distal pattern formation involved in nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10]
synonym: "proximal-distal pattern formation involved in nephron development" EXACT [GOC:mtg_kidney_jan10]
synonym: "proximal/distal nephron patterning" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0009954 ! proximal/distal pattern formation
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072048
name: renal system pattern specification
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10]
subset: gocheck_do_not_annotate
synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0072049
name: comma-shaped body morphogenesis
namespace: biological_process
def: "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072050
name: S-shaped body morphogenesis
namespace: biological_process
def: "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072051
name: juxtaglomerular apparatus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072052
name: juxtaglomerulus cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072051 ! juxtaglomerular apparatus development

[Term]
id: GO:0072053
name: renal inner medulla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney." [GOC:mtg_kidney_jan10]
synonym: "inner renal medulla development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072054
name: renal outer medulla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla." [GOC:mtg_kidney_jan10]
synonym: "outer renal medulla development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072055
name: renal cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072056
name: pyramid development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10]
synonym: "kidney pyramid development" EXACT [GOC:mah]
synonym: "pyramids development" EXACT [GOC:mah]
synonym: "renal medulla development" EXACT [GOC:mah]
synonym: "renal pyramid development" EXACT [GOC:mah]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072057
name: inner stripe development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072054 ! renal outer medulla development

[Term]
id: GO:0072058
name: outer stripe development
namespace: biological_process
def: "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072054 ! renal outer medulla development

[Term]
id: GO:0072059
name: cortical collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0072060
name: outer medullary collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development

[Term]
id: GO:0072061
name: inner medullary collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development

[Term]
id: GO:0072062
name: proximal convoluted tubule segment 1 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "S1 cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072031 ! proximal convoluted tubule segment 1 development

[Term]
id: GO:0072063
name: short descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072030 ! short nephron development

[Term]
id: GO:0072064
name: long descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072029 ! long nephron development

[Term]
id: GO:0072065
name: long descending thin limb bend development
namespace: biological_process
def: "The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0072064 ! long descending thin limb development

[Term]
id: GO:0072066
name: prebend segment development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0072022 ! descending thin limb development

[Term]
id: GO:0072067
name: early distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072025 ! distal convoluted tubule development

[Term]
id: GO:0072068
name: late distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072025 ! distal convoluted tubule development

[Term]
id: GO:0072069
name: DCT cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072025 ! distal convoluted tubule development

[Term]
id: GO:0072070
name: loop of Henle development
namespace: biological_process
alt_id: GO:0072018
def: "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "intermediate tubule development" EXACT []
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072071
name: kidney interstitial fibroblast differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development

[Term]
id: GO:0072072
name: kidney stroma development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061448 ! connective tissue development
is_a: GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072073
name: kidney epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072074
name: kidney mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072075
name: metanephric mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072076
name: nephrogenic mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072077
name: renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0072087 ! renal vesicle development
relationship: part_of GO:0072088 ! nephron epithelium morphogenesis

[Term]
id: GO:0072078
name: nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061333 ! renal tubule morphogenesis
is_a: GO:0072088 ! nephron epithelium morphogenesis
relationship: part_of GO:0072080 ! nephron tubule development

[Term]
id: GO:0072079
name: nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0072078 ! nephron tubule morphogenesis

[Term]
id: GO:0072080
name: nephron tubule development
namespace: biological_process
def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061326 ! renal tubule development
is_a: GO:0072009 ! nephron epithelium development

[Term]
id: GO:0072081
name: specification of nephron tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0007379 ! segment specification
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072047 ! proximal/distal pattern formation involved in nephron development
relationship: part_of GO:0072079 ! nephron tubule formation

[Term]
id: GO:0072082
name: specification of proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072158 ! proximal tubule morphogenesis

[Term]
id: GO:0072084
name: specification of distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072156 ! distal tubule morphogenesis

[Term]
id: GO:0072085
name: specification of connecting tubule identity
namespace: biological_process
def: "The process in which the connecting tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072027 ! connecting tubule development

[Term]
id: GO:0072086
name: specification of loop of Henle identity
namespace: biological_process
alt_id: GO:0072083
def: "The process in which the loop of Henle of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "specification of intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072070 ! loop of Henle development

[Term]
id: GO:0072087
name: renal vesicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0072009 ! nephron epithelium development

[Term]
id: GO:0072088
name: nephron epithelium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072089
name: stem cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0072090
name: mesenchymal stem cell proliferation involved in nephron morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0097168 ! mesenchymal stem cell proliferation

[Term]
id: GO:0072091
name: regulation of stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0072089 ! stem cell proliferation

[Term]
id: GO:0072092
name: ureteric bud invasion
namespace: biological_process
def: "The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060677 ! ureteric bud elongation
relationship: part_of GO:0072093 ! metanephric renal vesicle formation

[Term]
id: GO:0072093
name: metanephric renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072033 ! renal vesicle formation
relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis

[Term]
id: GO:0072094
name: metanephric renal vesicle induction
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle." [GOC:mtg_kidney_jan10]
synonym: "positive regulation of metanephros formation" BROAD [GOC:mtg_kidney_jan10]
is_a: GO:0072034 ! renal vesicle induction
is_a: GO:0072216 ! positive regulation of metanephros development
relationship: positively_regulates GO:0072093 ! metanephric renal vesicle formation

[Term]
id: GO:0072095
name: regulation of branch elongation involved in ureteric bud branching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0060681 ! branch elongation involved in ureteric bud branching

[Term]
id: GO:0072096
name: negative regulation of branch elongation involved in ureteric bud branching
namespace: biological_process
def: "Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0072095 ! regulation of branch elongation involved in ureteric bud branching
relationship: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching

[Term]
id: GO:0072097
name: obsolete negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of branch elongation involved in ureteric bud branching by BMP signalling pathway" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030509
consider: GO:0072096

[Term]
id: GO:0072098
name: anterior/posterior pattern specification involved in kidney development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0061004 ! pattern specification involved in kidney development

[Term]
id: GO:0072099
name: anterior/posterior pattern specification involved in ureteric bud development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
relationship: part_of GO:0001657 ! ureteric bud development

[Term]
id: GO:0072100
name: specification of ureteric bud anterior/posterior symmetry
namespace: biological_process
def: "The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10]
synonym: "specification of ureteric bud anterior/posterior asymmetry" EXACT [GOC:dph]
is_a: GO:0009799 ! specification of symmetry
is_a: GO:0072099 ! anterior/posterior pattern specification involved in ureteric bud development

[Term]
id: GO:0072101
name: obsolete specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway" EXACT [GOC:dph]
synonym: "specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0030509
consider: GO:0072100

[Term]
id: GO:0072102
name: glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0072103
name: glomerulus vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0048514 ! blood vessel morphogenesis
is_a: GO:0061439 ! kidney vasculature morphogenesis
relationship: part_of GO:0072012 ! glomerulus vasculature development
relationship: part_of GO:0072102 ! glomerulus morphogenesis

[Term]
id: GO:0072104
name: glomerular capillary formation
namespace: biological_process
def: "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10]
is_a: GO:0001525 ! angiogenesis
relationship: part_of GO:0072103 ! glomerulus vasculature morphogenesis

[Term]
id: GO:0072105
name: ureteric peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0014849 ! ureter smooth muscle contraction
is_a: GO:0030432 ! peristalsis

[Term]
id: GO:0072106
name: regulation of ureteric bud formation
namespace: biological_process
def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0060676 ! ureteric bud formation

[Term]
id: GO:0072107
name: positive regulation of ureteric bud formation
namespace: biological_process
def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0072106 ! regulation of ureteric bud formation
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
is_a: GO:1905278 ! positive regulation of epithelial tube formation
relationship: positively_regulates GO:0060676 ! ureteric bud formation

[Term]
id: GO:0072108
name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
relationship: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis

[Term]
id: GO:0072109
name: glomerular mesangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0072012 ! glomerulus vasculature development

[Term]
id: GO:0072110
name: glomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072109 ! glomerular mesangium development

[Term]
id: GO:0072111
name: cell proliferation involved in kidney development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072112
name: podocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "glomerular visceral epithelial cell differentiation" EXACT []
is_a: GO:0061318 ! renal filtration cell differentiation
is_a: GO:0072311 ! glomerular epithelial cell differentiation

[Term]
id: GO:0072113
name: head kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
is_a: GO:0048793 ! pronephros development

[Term]
id: GO:0072114
name: pronephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney morphogenesis" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0072115
name: head kidney morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072114 ! pronephros morphogenesis
relationship: part_of GO:0072113 ! head kidney development

[Term]
id: GO:0072116
name: pronephros formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048645 ! animal organ formation
is_a: GO:0072003 ! kidney rudiment formation
relationship: part_of GO:0072114 ! pronephros morphogenesis

[Term]
id: GO:0072117
name: head kidney formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072116 ! pronephros formation
relationship: part_of GO:0072115 ! head kidney morphogenesis

[Term]
id: GO:0072118
name: pronephros structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney structural organization" EXACT [GOC:mtg_kidney_jan10]
synonym: "pronephros structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0072114 ! pronephros morphogenesis

[Term]
id: GO:0072119
name: head kidney structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
synonym: "head kidney structural organisation" EXACT [GOC:mah]
is_a: GO:0072118 ! pronephros structural organization
relationship: part_of GO:0072115 ! head kidney morphogenesis

[Term]
id: GO:0072120
name: pronephros maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney maturation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048799 ! animal organ maturation
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0072121
name: head kidney maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072120 ! pronephros maturation
relationship: part_of GO:0072113 ! head kidney development

[Term]
id: GO:0072122
name: extraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10]
synonym: "Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072123
name: intraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10]
is_a: GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072124
name: regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
relationship: regulates GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072125
name: negative regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development
relationship: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072126
name: positive regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development
relationship: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072127
name: renal capsule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072128
name: renal capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0072127 ! renal capsule development

[Term]
id: GO:0072129
name: renal capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072128 ! renal capsule morphogenesis

[Term]
id: GO:0072130
name: renal capsule specification
namespace: biological_process
def: "The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
is_a: GO:0003002 ! regionalization
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072129 ! renal capsule formation

[Term]
id: GO:0072131
name: kidney mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072132
name: mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0060485 ! mesenchyme development

[Term]
id: GO:0072133
name: metanephric mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0072075 ! metanephric mesenchyme development

[Term]
id: GO:0072134
name: nephrogenic mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0072076 ! nephrogenic mesenchyme development

[Term]
id: GO:0072135
name: kidney mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072136
name: metanephric mesenchymal cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population." [GOC:mtg_kidney_jan10]
is_a: GO:0072135 ! kidney mesenchymal cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072075 ! metanephric mesenchyme development

[Term]
id: GO:0072137
name: condensed mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0072138
name: mesenchymal cell proliferation involved in ureteric bud development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
relationship: part_of GO:0001657 ! ureteric bud development

[Term]
id: GO:0072139
name: glomerular parietal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0072311 ! glomerular epithelial cell differentiation

[Term]
id: GO:0072140
name: DCT cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072069 ! DCT cell differentiation

[Term]
id: GO:0072141
name: renal interstitial fibroblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation

[Term]
id: GO:0072142
name: juxtaglomerulus cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation

[Term]
id: GO:0072143
name: mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072007 ! mesangial cell differentiation

[Term]
id: GO:0072144
name: glomerular mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
is_a: GO:0072143 ! mesangial cell development
relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation

[Term]
id: GO:0072145
name: proximal convoluted tubule segment 1 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "S1 cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation

[Term]
id: GO:0072146
name: DCT cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072069 ! DCT cell differentiation

[Term]
id: GO:0072147
name: glomerular parietal epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10]
synonym: "Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072148 ! epithelial cell fate commitment
is_a: GO:0072314 ! glomerular epithelial cell fate commitment
relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation

[Term]
id: GO:0072148
name: epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0072149
name: podocyte cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "glomerular visceral epithelial cell fate commitment" EXACT []
is_a: GO:0072148 ! epithelial cell fate commitment
is_a: GO:0072314 ! glomerular epithelial cell fate commitment
relationship: part_of GO:0072112 ! podocyte differentiation

[Term]
id: GO:0072150
name: juxtaglomerulus cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation

[Term]
id: GO:0072151
name: mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072007 ! mesangial cell differentiation

[Term]
id: GO:0072152
name: glomerular mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072151 ! mesangial cell fate commitment
relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation

[Term]
id: GO:0072153
name: renal interstitial fibroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation

[Term]
id: GO:0072154
name: proximal convoluted tubule segment 1 cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "S1 cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation

[Term]
id: GO:0072155
name: epithelial cell migration involved in nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0010631 ! epithelial cell migration
is_a: GO:0035787 ! cell migration involved in kidney development
relationship: part_of GO:0072078 ! nephron tubule morphogenesis

[Term]
id: GO:0072156
name: distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072017 ! distal tubule development

[Term]
id: GO:0072157
name: epithelial cell migration involved in distal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
relationship: part_of GO:0072156 ! distal tubule morphogenesis

[Term]
id: GO:0072158
name: proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072014 ! proximal tubule development

[Term]
id: GO:0072159
name: epithelial cell migration involved in proximal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
relationship: part_of GO:0072158 ! proximal tubule morphogenesis

[Term]
id: GO:0072160
name: nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: part_of GO:0072080 ! nephron tubule development

[Term]
id: GO:0072161
name: mesenchymal cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
is_a: GO:2001012 ! mesenchymal cell differentiation involved in renal system development
relationship: part_of GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072162
name: metanephric mesenchymal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072075 ! metanephric mesenchyme development

[Term]
id: GO:0072163
name: mesonephric epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0072164
name: mesonephric tubule development
namespace: biological_process
def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072163 ! mesonephric epithelium development

[Term]
id: GO:0072165
name: anterior mesonephric tubule development
namespace: biological_process
def: "The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0072166
name: posterior mesonephric tubule development
namespace: biological_process
def: "The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0072167
name: specification of mesonephric tubule identity
namespace: biological_process
def: "The process in which the tubules of the mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072172 ! mesonephric tubule formation

[Term]
id: GO:0072168
name: specification of anterior mesonephric tubule identity
namespace: biological_process
def: "The process in which the tubules of the anterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
is_a: GO:0072167 ! specification of mesonephric tubule identity
relationship: part_of GO:0072165 ! anterior mesonephric tubule development

[Term]
id: GO:0072169
name: specification of posterior mesonephric tubule identity
namespace: biological_process
def: "The process in which the tubules of the posterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
is_a: GO:0072167 ! specification of mesonephric tubule identity
relationship: part_of GO:0072166 ! posterior mesonephric tubule development

[Term]
id: GO:0072170
name: metanephric tubule development
namespace: biological_process
def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072207 ! metanephric epithelium development

[Term]
id: GO:0072171
name: mesonephric tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0072172
name: mesonephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
relationship: part_of GO:0072171 ! mesonephric tubule morphogenesis

[Term]
id: GO:0072173
name: metanephric tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0072170 ! metanephric tubule development

[Term]
id: GO:0072174
name: metanephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0072173 ! metanephric tubule morphogenesis

[Term]
id: GO:0072175
name: epithelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10]
is_a: GO:0035148 ! tube formation
relationship: part_of GO:0060562 ! epithelial tube morphogenesis

[Term]
id: GO:0072176
name: nephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072073 ! kidney epithelium development

[Term]
id: GO:0072177
name: mesonephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct development" EXACT [GOC:dph]
is_a: GO:0072164 ! mesonephric tubule development
is_a: GO:0072176 ! nephric duct development

[Term]
id: GO:0072178
name: nephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0072176 ! nephric duct development

[Term]
id: GO:0072179
name: nephric duct formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0072178 ! nephric duct morphogenesis

[Term]
id: GO:0072180
name: mesonephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct morphogenesis" RELATED [GOC:dph]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
is_a: GO:0072178 ! nephric duct morphogenesis
relationship: part_of GO:0072177 ! mesonephric duct development

[Term]
id: GO:0072181
name: mesonephric duct formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct formation" EXACT [GOC:dph]
is_a: GO:0072172 ! mesonephric tubule formation
is_a: GO:0072179 ! nephric duct formation
is_a: GO:0072180 ! mesonephric duct morphogenesis

[Term]
id: GO:0072182
name: regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
relationship: regulates GO:0072160 ! nephron tubule epithelial cell differentiation

[Term]
id: GO:0072183
name: negative regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
relationship: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation

[Term]
id: GO:0072184
name: renal vesicle progenitor cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072087 ! renal vesicle development

[Term]
id: GO:0072185
name: metanephric cap development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10]
is_a: GO:0072075 ! metanephric mesenchyme development

[Term]
id: GO:0072186
name: metanephric cap morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10]
is_a: GO:0072133 ! metanephric mesenchyme morphogenesis
relationship: part_of GO:0072185 ! metanephric cap development

[Term]
id: GO:0072187
name: metanephric cap formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072186 ! metanephric cap morphogenesis

[Term]
id: GO:0072188
name: metanephric cap specification
namespace: biological_process
def: "The process in which the metanephric cap acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072048 ! renal system pattern specification
is_a: GO:0072187 ! metanephric cap formation
is_a: GO:0072268 ! pattern specification involved in metanephros development

[Term]
id: GO:0072189
name: ureter development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0072190
name: ureter urothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter." [GOC:mtg_kidney_jan10]
synonym: "ureter epithelium development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0072189 ! ureter development

[Term]
id: GO:0072191
name: ureter smooth muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048745 ! smooth muscle tissue development
relationship: part_of GO:0072189 ! ureter development

[Term]
id: GO:0072192
name: ureter epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter." [GOC:mtg_kidney_jan10]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0072190 ! ureter urothelium development

[Term]
id: GO:0072193
name: ureter smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter." [GOC:mtg_kidney_jan10]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0072191 ! ureter smooth muscle development

[Term]
id: GO:0072194
name: kidney smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048745 ! smooth muscle tissue development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072195
name: kidney smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0051145 ! smooth muscle cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072194 ! kidney smooth muscle tissue development

[Term]
id: GO:0072196
name: proximal/distal pattern formation involved in pronephric nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros." [GOC:mtg_kidney_jan10]
synonym: "pronephros proximal/distal pattern formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development
relationship: part_of GO:0039019 ! pronephric nephron development

[Term]
id: GO:0072197
name: ureter morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0072189 ! ureter development

[Term]
id: GO:0072198
name: mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development." [GOC:mtg_kidney_jan10]
synonym: "ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
relationship: part_of GO:0072189 ! ureter development

[Term]
id: GO:0072199
name: regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
synonym: "regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development

[Term]
id: GO:0072200
name: negative regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
synonym: "negative regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "negative regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development
is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation
relationship: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development

[Term]
id: GO:0072201
name: negative regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: negatively_regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0072202
name: cell differentiation involved in metanephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state." [GOC:mah, GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072203
name: cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072204
name: cell-cell signaling involved in metanephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in metanephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072205
name: metanephric collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072206
name: metanephric juxtaglomerular apparatus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10]
is_a: GO:0072051 ! juxtaglomerular apparatus development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072207
name: metanephric epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072208
name: metanephric smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072194 ! kidney smooth muscle tissue development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072209
name: metanephric mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072007 ! mesangial cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development

[Term]
id: GO:0072210
name: metanephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072211
name: metanephric pyramids development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10]
synonym: "metanephric kidney pyramid development" EXACT [GOC:mah]
synonym: "metanephric pyramid development" EXACT [GOC:mah]
synonym: "metanephric renal medulla development" EXACT [GOC:mah]
synonym: "metanephric renal pyramid development" EXACT [GOC:mah]
is_a: GO:0072056 ! pyramid development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072212
name: obsolete regulation of transcription from RNA polymerase II promoter involved in metanephros development
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the metanephros progresses from its initial formation to the mature state." [GOC:mtg_kidney_jan10]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0072213
name: metanephric capsule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072127 ! renal capsule development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072214
name: metanephric cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060485 ! mesenchyme development
is_a: GO:0072055 ! renal cortex development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072215
name: regulation of metanephros development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0001656 ! metanephros development

[Term]
id: GO:0072216
name: positive regulation of metanephros development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:0090184 ! positive regulation of kidney development
relationship: positively_regulates GO:0001656 ! metanephros development

[Term]
id: GO:0072217
name: negative regulation of metanephros development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:0090185 ! negative regulation of kidney development
relationship: negatively_regulates GO:0001656 ! metanephros development

[Term]
id: GO:0072218
name: metanephric ascending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10]
is_a: GO:0072021 ! ascending thin limb development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072236 ! metanephric loop of Henle development

[Term]
id: GO:0072219
name: metanephric cortical collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10]
is_a: GO:0072059 ! cortical collecting duct development

[Term]
id: GO:0072220
name: metanephric descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072236 ! metanephric loop of Henle development

[Term]
id: GO:0072221
name: metanephric distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10]
is_a: GO:0072025 ! distal convoluted tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072235 ! metanephric distal tubule development

[Term]
id: GO:0072222
name: metanephric early distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0072067 ! early distal convoluted tubule development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development

[Term]
id: GO:0072223
name: metanephric glomerular mesangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072109 ! glomerular mesangium development
relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development

[Term]
id: GO:0072224
name: metanephric glomerulus development
namespace: biological_process
def: "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros." [GOC:mah]
synonym: "metanephric glomerular development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0032835 ! glomerulus development
relationship: part_of GO:0072210 ! metanephric nephron development

[Term]
id: GO:0072225
name: metanephric late distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0072068 ! late distal convoluted tubule development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development

[Term]
id: GO:0072226
name: metanephric long descending thin limb bend development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072065 ! long descending thin limb bend development
relationship: part_of GO:0072220 ! metanephric descending thin limb development
relationship: part_of GO:0072269 ! metanephric long descending thin limb development

[Term]
id: GO:0072227
name: metanephric macula densa development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072024 ! macula densa development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development

[Term]
id: GO:0072228
name: metanephric prebend segment development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10]
is_a: GO:0072066 ! prebend segment development
relationship: part_of GO:0072220 ! metanephric descending thin limb development

[Term]
id: GO:0072229
name: metanephric proximal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072019 ! proximal convoluted tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072237 ! metanephric proximal tubule development

[Term]
id: GO:0072230
name: metanephric proximal straight tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule." [GOC:mtg_kidney_jan10]
synonym: "metanephric S3 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072020 ! proximal straight tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072237 ! metanephric proximal tubule development

[Term]
id: GO:0072231
name: metanephric proximal convoluted tubule segment 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "metanephric S1 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072031 ! proximal convoluted tubule segment 1 development
relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development

[Term]
id: GO:0072232
name: metanephric proximal convoluted tubule segment 2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "metanephric S2 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072032 ! proximal convoluted tubule segment 2 development
relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development

[Term]
id: GO:0072233
name: metanephric thick ascending limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "metanephric TAL development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072023 ! thick ascending limb development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072235 ! metanephric distal tubule development

[Term]
id: GO:0072234
name: metanephric nephron tubule development
namespace: biological_process
def: "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
is_a: GO:0072170 ! metanephric tubule development
is_a: GO:0072243 ! metanephric nephron epithelium development

[Term]
id: GO:0072235
name: metanephric distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072017 ! distal tubule development
is_a: GO:0072234 ! metanephric nephron tubule development

[Term]
id: GO:0072236
name: metanephric loop of Henle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric intermediate tubule development" EXACT []
is_a: GO:0072070 ! loop of Henle development
is_a: GO:0072234 ! metanephric nephron tubule development

[Term]
id: GO:0072237
name: metanephric proximal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072014 ! proximal tubule development
is_a: GO:0072234 ! metanephric nephron tubule development

[Term]
id: GO:0072238
name: metanephric long nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072029 ! long nephron development
is_a: GO:0072210 ! metanephric nephron development

[Term]
id: GO:0072239
name: metanephric glomerulus vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10]
synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072012 ! glomerulus vasculature development
relationship: part_of GO:0072224 ! metanephric glomerulus development

[Term]
id: GO:0072240
name: metanephric DCT cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "metanephric distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072069 ! DCT cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development

[Term]
id: GO:0072241
name: metanephric DCT cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "metanephric distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072140 ! DCT cell development
relationship: part_of GO:0072240 ! metanephric DCT cell differentiation

[Term]
id: GO:0072242
name: metanephric DCT cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell." [GOC:mtg_kidney_jan10]
synonym: "metanephric distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072146 ! DCT cell fate commitment
relationship: part_of GO:0072240 ! metanephric DCT cell differentiation

[Term]
id: GO:0072243
name: metanephric nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072207 ! metanephric epithelium development

[Term]
id: GO:0072244
name: metanephric glomerular epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072010 ! glomerular epithelium development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072224 ! metanephric glomerulus development

[Term]
id: GO:0072245
name: metanephric glomerular parietal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation
is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation

[Term]
id: GO:0072246
name: metanephric glomerular parietal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
synonym: "metanephric Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072016 ! glomerular parietal epithelial cell development
is_a: GO:0072313 ! metanephric glomerular epithelial cell development
relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation

[Term]
id: GO:0072247
name: metanephric glomerular parietal epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10]
synonym: "metanephric Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment
is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment
relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation

[Term]
id: GO:0072248
name: metanephric podocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric glomerular visceral epithelial cell differentiation" EXACT []
is_a: GO:0072112 ! podocyte differentiation
is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation

[Term]
id: GO:0072249
name: metanephric podocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric glomerular visceral epithelial cell development" EXACT []
is_a: GO:0072015 ! podocyte development
is_a: GO:0072313 ! metanephric glomerular epithelial cell development
relationship: part_of GO:0072248 ! metanephric podocyte differentiation

[Term]
id: GO:0072250
name: metanephric podocyte cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric glomerular visceral epithelial cell fate commitment" EXACT []
is_a: GO:0072149 ! podocyte cell fate commitment
is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment
relationship: part_of GO:0072248 ! metanephric podocyte differentiation

[Term]
id: GO:0072251
name: metanephric juxtaglomerulus cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072052 ! juxtaglomerulus cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development

[Term]
id: GO:0072252
name: metanephric juxtaglomerulus cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072142 ! juxtaglomerulus cell development
relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation

[Term]
id: GO:0072253
name: metanephric juxtaglomerulus cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072150 ! juxtaglomerulus cell fate commitment
relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation

[Term]
id: GO:0072254
name: metanephric glomerular mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072008 ! glomerular mesangial cell differentiation
is_a: GO:0072209 ! metanephric mesangial cell differentiation
relationship: part_of GO:0072223 ! metanephric glomerular mesangium development

[Term]
id: GO:0072255
name: metanephric glomerular mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072144 ! glomerular mesangial cell development
relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation

[Term]
id: GO:0072256
name: metanephric glomerular mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072152 ! glomerular mesangial cell fate commitment
relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation

[Term]
id: GO:0072257
name: metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072234 ! metanephric nephron tubule development

[Term]
id: GO:0072258
name: metanephric interstitial fibroblast differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "metanephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072071 ! kidney interstitial fibroblast differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development

[Term]
id: GO:0072259
name: metanephric interstitial fibroblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "metanephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072141 ! renal interstitial fibroblast development
relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation

[Term]
id: GO:0072260
name: metanephric interstitial fibroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast." [GOC:mtg_kidney_jan10]
synonym: "metanephros interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072153 ! renal interstitial fibroblast fate commitment
relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation

[Term]
id: GO:0072261
name: metanephric extraglomerular mesangial cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10]
synonym: "metanephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "metanephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072122 ! extraglomerular mesangial cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072210 ! metanephric nephron development

[Term]
id: GO:0072262
name: metanephric glomerular mesangial cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10]
is_a: GO:0072110 ! glomerular mesangial cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072223 ! metanephric glomerular mesangium development

[Term]
id: GO:0072263
name: metanephric intraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10]
is_a: GO:0072123 ! intraglomerular mesangial cell proliferation
is_a: GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development

[Term]
id: GO:0072264
name: metanephric glomerular endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072011 ! glomerular endothelium development
is_a: GO:0072244 ! metanephric glomerular epithelium development
relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development

[Term]
id: GO:0072265
name: metanephric capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072128 ! renal capsule morphogenesis
relationship: part_of GO:0072213 ! metanephric capsule development

[Term]
id: GO:0072266
name: metanephric capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072129 ! renal capsule formation
relationship: part_of GO:0072265 ! metanephric capsule morphogenesis

[Term]
id: GO:0072267
name: metanephric capsule specification
namespace: biological_process
def: "The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
is_a: GO:0072130 ! renal capsule specification
is_a: GO:0072268 ! pattern specification involved in metanephros development
relationship: part_of GO:0072266 ! metanephric capsule formation

[Term]
id: GO:0072268
name: pattern specification involved in metanephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "metanephros pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "metanephros pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "pattern formation involved in metanephros development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072269
name: metanephric long descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072064 ! long descending thin limb development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072238 ! metanephric long nephron development

[Term]
id: GO:0072270
name: metanephric short nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10]
is_a: GO:0072030 ! short nephron development
is_a: GO:0072210 ! metanephric nephron development

[Term]
id: GO:0072271
name: metanephric short descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072063 ! short descending thin limb development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072270 ! metanephric short nephron development

[Term]
id: GO:0072272
name: proximal/distal pattern formation involved in metanephric nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10]
synonym: "proximal-distal pattern formation involved in metanephric nephron development" EXACT [GOC:mtg_kidney_jan10]
synonym: "proximal/distal metanephric nephron patterning" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development
is_a: GO:0072268 ! pattern specification involved in metanephros development
relationship: part_of GO:0072210 ! metanephric nephron development

[Term]
id: GO:0072273
name: metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0003338 ! metanephros morphogenesis
relationship: part_of GO:0072210 ! metanephric nephron development

[Term]
id: GO:0072274
name: metanephric glomerular basement membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10]
is_a: GO:0032836 ! glomerular basement membrane development
relationship: part_of GO:0072224 ! metanephric glomerulus development

[Term]
id: GO:0072275
name: metanephric glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072102 ! glomerulus morphogenesis
relationship: part_of GO:0072224 ! metanephric glomerulus development

[Term]
id: GO:0072276
name: metanephric glomerulus vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072103 ! glomerulus vasculature morphogenesis
relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development
relationship: part_of GO:0072275 ! metanephric glomerulus morphogenesis

[Term]
id: GO:0072277
name: metanephric glomerular capillary formation
namespace: biological_process
def: "The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10]
is_a: GO:0072104 ! glomerular capillary formation
relationship: part_of GO:0072276 ! metanephric glomerulus vasculature morphogenesis

[Term]
id: GO:0072278
name: metanephric comma-shaped body morphogenesis
namespace: biological_process
def: "The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072049 ! comma-shaped body morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072279
name: convergent extension involved in metanephric nephron morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072280
name: establishment of planar polarity involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "establishment of planar cell polarity involved in metanephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10]
is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072281
name: mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072282
name: metanephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
is_a: GO:0072173 ! metanephric tubule morphogenesis
relationship: part_of GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072283
name: metanephric renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072077 ! renal vesicle morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072284
name: metanephric S-shaped body morphogenesis
namespace: biological_process
def: "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072050 ! S-shaped body morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072285
name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation
relationship: part_of GO:0072093 ! metanephric renal vesicle formation

[Term]
id: GO:0072286
name: metanephric connecting tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric connecting duct development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072027 ! connecting tubule development
is_a: GO:0072234 ! metanephric nephron tubule development

[Term]
id: GO:0072287
name: metanephric distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072156 ! distal tubule morphogenesis
is_a: GO:0072282 ! metanephric nephron tubule morphogenesis
relationship: part_of GO:0072235 ! metanephric distal tubule development

[Term]
id: GO:0072288
name: metanephric proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072158 ! proximal tubule morphogenesis
is_a: GO:0072282 ! metanephric nephron tubule morphogenesis
relationship: part_of GO:0072237 ! metanephric proximal tubule development

[Term]
id: GO:0072289
name: metanephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
is_a: GO:0072174 ! metanephric tubule formation
relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis

[Term]
id: GO:0072290
name: epithelial cell migration involved in metanephric nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0035788 ! cell migration involved in metanephros development
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis

[Term]
id: GO:0072291
name: epithelial cell migration involved in metanephric distal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis
is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis
relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis

[Term]
id: GO:0072292
name: epithelial cell migration involved in metanephric proximal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis
is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis
relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis

[Term]
id: GO:0072293
name: specification of metanephric nephron tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
is_a: GO:0072268 ! pattern specification involved in metanephros development
relationship: part_of GO:0072272 ! proximal/distal pattern formation involved in metanephric nephron development
relationship: part_of GO:0072289 ! metanephric nephron tubule formation

[Term]
id: GO:0072294
name: specification of metanephric connecting tubule identity
namespace: biological_process
def: "The process in which the connecting tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072085 ! specification of connecting tubule identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072286 ! metanephric connecting tubule development

[Term]
id: GO:0072295
name: specification of metanephric distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072084 ! specification of distal tubule identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis

[Term]
id: GO:0072296
name: specification of metanephric loop of Henle identity
namespace: biological_process
def: "The process in which the loop of Henle of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "specification of metanephric intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072086 ! specification of loop of Henle identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072236 ! metanephric loop of Henle development

[Term]
id: GO:0072297
name: specification of metanephric proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072082 ! specification of proximal tubule identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis

[Term]
id: GO:0072298
name: regulation of metanephric glomerulus development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0001656 ! metanephros development
is_a: GO:0090192 ! regulation of glomerulus development
relationship: regulates GO:0072224 ! metanephric glomerulus development

[Term]
id: GO:0072299
name: negative regulation of metanephric glomerulus development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:0072298 ! regulation of metanephric glomerulus development
is_a: GO:0090194 ! negative regulation of glomerulus development
relationship: negatively_regulates GO:0072224 ! metanephric glomerulus development

[Term]
id: GO:0072300
name: positive regulation of metanephric glomerulus development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:0072298 ! regulation of metanephric glomerulus development
is_a: GO:0090193 ! positive regulation of glomerulus development
relationship: positively_regulates GO:0072224 ! metanephric glomerulus development

[Term]
id: GO:0072301
name: regulation of metanephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
relationship: regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development

[Term]
id: GO:0072302
name: negative regulation of metanephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation
is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation
relationship: negatively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development

[Term]
id: GO:0072303
name: positive regulation of glomerular metanephric mesangial cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation
is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation
relationship: positively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development

[Term]
id: GO:0072304
name: regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
relationship: regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

[Term]
id: GO:0072305
name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
is_a: GO:1900212 ! negative regulation of mesenchymal cell apoptotic process involved in metanephros development
relationship: negatively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

[Term]
id: GO:0072306
name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
is_a: GO:1900213 ! positive regulation of mesenchymal cell apoptotic process involved in metanephros development
relationship: positively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

[Term]
id: GO:0072307
name: regulation of metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
relationship: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation

[Term]
id: GO:0072308
name: negative regulation of metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation
is_a: GO:0072307 ! regulation of metanephric nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation

[Term]
id: GO:0072309
name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:0072310
name: glomerular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation

[Term]
id: GO:0072311
name: glomerular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: part_of GO:0072010 ! glomerular epithelium development

[Term]
id: GO:0072312
name: metanephric glomerular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072202 ! cell differentiation involved in metanephros development
is_a: GO:0072311 ! glomerular epithelial cell differentiation
relationship: part_of GO:0072244 ! metanephric glomerular epithelium development

[Term]
id: GO:0072313
name: metanephric glomerular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0072312 ! metanephric glomerular epithelial cell differentiation

[Term]
id: GO:0072314
name: glomerular epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation

[Term]
id: GO:0072315
name: metanephric glomerular epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072314 ! glomerular epithelial cell fate commitment

[Term]
id: GO:0072316
name: obsolete alpha-glucan catabolic process involved in ascospore release from ascus
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "alpha-glucan breakdown involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "alpha-glucan catabolism involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "alpha-glucan degradation involved in ascospore release from ascus" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072317
name: obsolete glucan endo-1,3-beta-D-glucosidase activity involved in ascospore release from ascus
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans that contributes to the release of ascospores from the ascus." [GOC:jl]
comment: This term was obsoleted because it should be captured as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0072318
name: clathrin coat disassembly
namespace: biological_process
def: "The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system." [PMID:11084334, PMID:11146663, PMID:8524399]
synonym: "clathrin-coat disassembly" EXACT [GOC:rb]
synonym: "clathrin-coat uncoating" EXACT [GOC:rb]
synonym: "clathrin-coated vesicle uncoating" EXACT [GOC:mah]
is_a: GO:0072319 ! vesicle uncoating

[Term]
id: GO:0072319
name: vesicle uncoating
namespace: biological_process
def: "A protein depolymerization process that results in the disassembly of vesicle coat proteins." [GOC:mah]
synonym: "vesicle coat disassembly" EXACT [GOC:mah]
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0072320
name: volume-sensitive chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah]
synonym: "swell-activated chloride channel" RELATED [GOC:sart, PMID:23056495]
is_a: GO:0005225 ! volume-sensitive anion channel activity
is_a: GO:0005254 ! chloride channel activity

[Term]
id: GO:0072321
name: obsolete chaperone-mediated protein transport
namespace: biological_process
def: "OBSOLETE. The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773]
comment: This term was obsoleted because it represents a function within a process.
is_obsolete: true
consider: GO:0015031
consider: GO:0140597

[Term]
id: GO:0072322
name: protein transport across periplasmic space
namespace: biological_process
alt_id: GO:0072323
def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall." [GOC:mah, PMID:20378773]
synonym: "chaperone-mediated protein transport across periplasmic space" NARROW []
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0072324
name: ascus epiplasm
namespace: cellular_component
def: "Ascus cytoplasm that is not packaged into ascospores." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mcc]
comment: Note that this term is an is_a child of 'cell part' because the epiplasm is extracellular to the spore (each of which is a cell) but within the ascus structure, and originated from cytoplasm.
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0072325
name: vulval cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0040025 ! vulval development

[Term]
id: GO:0072326
name: vulval cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0072325 ! vulval cell fate commitment

[Term]
id: GO:0072327
name: vulval cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0072325 ! vulval cell fate commitment

[Term]
id: GO:0072328
name: alkene binding
namespace: molecular_function
def: "Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:mah]
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0072329
name: monocarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0072330
name: monocarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]
synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah]
synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah]
synonym: "monocarboxylic acid formation" EXACT [GOC:mah]
synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0072331
name: signal transduction by p53 class mediator
namespace: biological_process
def: "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah]
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0072332
name: intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis]
synonym: "intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT []
synonym: "signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED []
is_a: GO:0072331 ! signal transduction by p53 class mediator
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0072333
name: obsolete anoikis by p53 class mediator
namespace: biological_process
def: "OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of anoikis." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because it is misleading, since anoikis occurs following detachment of cells from each other and/or from the culture surface; it is not p53 that induces such separation.
synonym: "anoikis by p53 class mediator" EXACT []
synonym: "anoikis by signal transduction by p53 class mediator" EXACT []
synonym: "signal transduction by p53 class mediator resulting in induction of anoikis" RELATED []
is_obsolete: true

[Term]
id: GO:0072334
name: UDP-galactose transmembrane transport
namespace: biological_process
alt_id: GO:0015785
def: "The process in which UDP-galactose is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "UDP-galactose membrane transport" EXACT []
synonym: "UDP-galactose transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport

[Term]
id: GO:0072335
name: obsolete regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling]
synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0014033
consider: GO:0060828

[Term]
id: GO:0072336
name: obsolete negative regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" RELATED []
synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0014033
consider: GO:0030178

[Term]
id: GO:0072337
name: modified amino acid transport
namespace: biological_process
def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "amino acid derivative transport" EXACT []
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0072338
name: lactam metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:mah]
synonym: "cellular lactam metabolic process" EXACT []
synonym: "cellular lactam metabolism" EXACT [GOC:mah]
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0072339
name: lactam biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:mah]
synonym: "cellular lactam anabolism" EXACT [GOC:mah]
synonym: "cellular lactam biosynthesis" EXACT [GOC:mah]
synonym: "cellular lactam biosynthetic process" EXACT []
synonym: "cellular lactam formation" EXACT [GOC:mah]
synonym: "cellular lactam synthesis" EXACT [GOC:mah]
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:0072340
name: lactam catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:mah]
synonym: "cellular lactam breakdown" EXACT [GOC:mah]
synonym: "cellular lactam catabolic process" EXACT []
synonym: "cellular lactam catabolism" EXACT [GOC:mah]
synonym: "cellular lactam degradation" EXACT [GOC:mah]
is_a: GO:0009056 ! catabolic process
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:0072341
name: modified amino acid binding
namespace: molecular_function
def: "Binding to a modified amino acid." [GOC:mah]
synonym: "amino acid derivative binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0072342
name: response to anion stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment." [GOC:cvs, PMID:19641131]
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0072343
name: pancreatic stellate cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus." [CL:0002410, GOC:mah, PMID:17200706]
is_a: GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0072344
name: rescue of stalled ribosome
namespace: biological_process
def: "A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]
is_a: GO:0006414 ! translational elongation
is_a: GO:0032790 ! ribosome disassembly

[Term]
id: GO:0072345
name: NAADP-sensitive calcium-release channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428]
xref: Reactome:R-HSA-2685505 "TPCN1/2 transport lysosomal Ca2+ to cytosol"
is_a: GO:0015278 ! intracellularly gated calcium channel activity

[Term]
id: GO:0072346
name: cADPR-sensitive calcium-release channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts." [PMID:11752598]
is_a: GO:0015278 ! intracellularly gated calcium channel activity

[Term]
id: GO:0072347
name: response to anesthetic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [GOC:sart]
synonym: "response to anaesthetic" EXACT [GOC:mah]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0072348
name: sulfur compound transport
namespace: biological_process
def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "sulfur-containing compound transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport

[Term]
id: GO:0072349
name: modified amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah]
synonym: "amino acid derivative transmembrane transporter activity" EXACT []
synonym: "modified amino acid transporter activity" BROAD [GOC:mah]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0072350
name: tricarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [GOC:mah]
synonym: "tricarboxylic acid metabolism" EXACT [GOC:mah]
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0072351
name: tricarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [GOC:mah]
synonym: "tricarboxylate biosynthesis" EXACT [GOC:mah]
synonym: "tricarboxylate biosynthetic process" EXACT [GOC:mah]
synonym: "tricarboxylic acid anabolism" EXACT [GOC:mah]
synonym: "tricarboxylic acid biosynthesis" EXACT [GOC:mah]
synonym: "tricarboxylic acid formation" EXACT [GOC:mah]
synonym: "tricarboxylic acid synthesis" EXACT [GOC:mah]
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0072352
name: tricarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [GOC:mah]
synonym: "tricarboxylate catabolic process" EXACT [GOC:mah]
synonym: "tricarboxylate catabolism" EXACT [GOC:mah]
synonym: "tricarboxylic acid breakdown" EXACT [GOC:mah]
synonym: "tricarboxylic acid catabolism" EXACT [GOC:mah]
synonym: "tricarboxylic acid degradation" EXACT [GOC:mah]
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0072353
name: obsolete cellular age-dependent response to reactive oxygen species
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:mah]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true
consider: GO:0034599

[Term]
id: GO:0072354
name: histone H3T3 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3." [GOC:mah]
synonym: "histone H3-T3 kinase activity" EXACT []
synonym: "histone kinase activity (H3-T3 specific)" EXACT []
synonym: "histone threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah]
synonym: "histone-threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah]
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0072355
name: obsolete histone H3-T3 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035403

[Term]
id: GO:0072356
name: chromosome passenger complex localization to kinetochore
namespace: biological_process
def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah]
synonym: "chromosomal passenger complex localization to kinetochore" EXACT [GOC:mah]
synonym: "chromosome passenger complex localisation to kinetochore" RELATED [GOC:mah]
synonym: "CPC complex localization to kinetochore" EXACT [GOC:vw]
synonym: "CPC localization to kinetochore" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0034501 ! protein localization to kinetochore

[Term]
id: GO:0072357
name: PTW/PP1 phosphatase complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061]
is_a: GO:0000164 ! protein phosphatase type 1 complex

[Term]
id: GO:0072359
name: circulatory system development
namespace: biological_process
alt_id: GO:0072358
def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]
subset: goslim_drosophila
synonym: "cardiovascular system development" NARROW []
is_a: GO:0048731 ! system development

[Term]
id: GO:0072360
name: vascular cord development
namespace: biological_process
def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072359 ! circulatory system development

[Term]
id: GO:0072361
name: obsolete regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0072362
name: obsolete regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: The reason for obsoletion is that this term represented a GO-CAM model.
synonym: "regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0072363
name: obsolete regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0072364
name: obsolete regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of cellular ketone metabolism by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072365
name: obsolete regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of cellular ketone metabolism by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072366
name: obsolete regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of cellular ketone metabolism by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072367
name: obsolete regulation of lipid transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0072368
name: obsolete regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0072369
name: obsolete regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:0072370
name: obsolete histone H2A-S121 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone." [GOC:mah, PMID:19965387]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A phosphorylation at S121" EXACT [GOC:mah]
synonym: "histone H2AS121 phosphorylation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0072371

[Term]
id: GO:0072371
name: histone H2AS121 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2A-serine (position 121) + ATP = histone H2A-phosphoserine (position 121) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 121 of histone H2A." [GOC:mah, PMID:19965387]
synonym: "histone H2A-S121 kinase activity" EXACT []
synonym: "histone kinase activity (H2A-S121 specific)" EXACT []
synonym: "histone serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah]
synonym: "histone-serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah]
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140995 ! histone H2A kinase activity

[Term]
id: GO:0072373
name: obsolete alpha-carotene epsilon hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O." [GOC:mah]
comment: This term was obsoleted because it represents a specific substrate of carotene epsilon hydroxylase activity ; GO:0072374
is_obsolete: true
replaced_by: GO:0072374

[Term]
id: GO:0072374
name: carotene epsilon hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. Zeinoxanthin may also be used as the substrate, in which case lutein is produced." [EC:1.14.14.158, PMID:8837513]
xref: EC:1.14.14.158
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0072375
name: medium-term memory
namespace: biological_process
def: "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375]
synonym: "middle-term memory" EXACT [GOC:sart]
synonym: "MTM" NARROW [GOC:sart]
is_a: GO:0007613 ! memory

[Term]
id: GO:0072376
name: protein activation cascade
namespace: biological_process
def: "A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events." [GOC:add, GOC:mah, GOC:pde]
synonym: "protein activation pathway" EXACT [GOC:add]
synonym: "protein activitory cascade" EXACT [GOC:add]
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0072377
name: blood coagulation, common pathway
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." [GOC:add, GOC:mah, GOC:pde, PMID:1931959]
comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation

[Term]
id: GO:0072378
name: blood coagulation, fibrin clot formation
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events." [GOC:add, GOC:mah, GOC:pde]
comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0007596 ! blood coagulation

[Term]
id: GO:0072379
name: ER membrane insertion complex
namespace: cellular_component
def: "A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast." [GOC:mah, PMID:20676083, PMID:20850366]
synonym: "endoplasmic reticulum membrane insertion complex" EXACT [GOC:mah]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0072380
name: TRC complex
namespace: cellular_component
def: "A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane." [GOC:mah, PMID:20850366, PMID:23142665]
synonym: "GET4-GET5 transmembrane domain recognition complex" RELATED []
synonym: "TMD recognition complex" EXACT [PMID:20850366]
is_a: GO:0072379 ! ER membrane insertion complex

[Term]
id: GO:0072381
name: obsolete positive regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mah]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling]
synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0014033
consider: GO:0030177

[Term]
id: GO:0072382
name: minus-end-directed vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule minus-end-directed vesicle distribution" NARROW [GOC:rl]
synonym: "microtubule minus-end-directed vesicle localization" EXACT [GOC:rl]
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0072385 ! minus-end-directed organelle transport along microtubule

[Term]
id: GO:0072383
name: plus-end-directed vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule plus-end-directed vesicle distribution" NARROW [GOC:rl]
synonym: "microtubule plus-end-directed vesicle localization" EXACT [GOC:rl]
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0072386 ! plus-end-directed organelle transport along microtubule

[Term]
id: GO:0072384
name: organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]
synonym: "microtubule-based organelle localization" EXACT [GOC:rl]
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0072385
name: minus-end-directed organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule minus-end-directed organelle distribution" NARROW [GOC:rl]
synonym: "microtubule minus-end-directed organelle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0072386
name: plus-end-directed organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule plus-end-directed organelle distribution" NARROW [GOC:rl]
synonym: "microtubule plus-end-directed organelle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0072387
name: flavin adenine dinucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
synonym: "FAD or FADH2 metabolic process" EXACT []
synonym: "flavin adenine dinucleotide metabolism" EXACT []
synonym: "flavin-adenine dinucleotide metabolic process" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process

[Term]
id: GO:0072388
name: flavin adenine dinucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
synonym: "FAD or FADH2 biosynthetic process" EXACT []
synonym: "flavin adenine dinucleotide anabolism" EXACT []
synonym: "flavin adenine dinucleotide biosynthesis" EXACT []
synonym: "flavin adenine dinucleotide formation" EXACT []
synonym: "flavin adenine dinucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process

[Term]
id: GO:0072389
name: flavin adenine dinucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
synonym: "FAD or FADH2 catabolic process" EXACT []
synonym: "flavin adenine dinucleotide breakdown" EXACT []
synonym: "flavin adenine dinucleotide catabolism" EXACT []
synonym: "flavin adenine dinucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process

[Term]
id: GO:0072390
name: phenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah]
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0072391
name: phenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072390 ! phenol metabolic process

[Term]
id: GO:0072392
name: phenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072390 ! phenol metabolic process

[Term]
id: GO:0072393
name: microtubule anchoring at microtubule organizing center
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938]
synonym: "microtubule anchoring at microtubule organising centre" EXACT [GOC:mah]
synonym: "microtubule anchoring at MTOC" EXACT [GOC:BHF]
is_a: GO:0034453 ! microtubule anchoring

[Term]
id: GO:0072394
name: obsolete detection of stimulus involved in cell cycle checkpoint
namespace: biological_process
alt_id: GO:0072403
alt_id: GO:0072406
def: "OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a cell cycle checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "cell cycle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cell cycle checkpoint sensor process" RELATED [GOC:mah]
synonym: "detection of stimulus involved in G1/S transition checkpoint" RELATED []
synonym: "detection of stimulus involved in G2/M transition checkpoint" RELATED []
synonym: "G1/S transition checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "G1/S transition checkpoint sensor process" RELATED [GOC:mah]
synonym: "G2/M transition checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "G2/M transition checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in cell cycle checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in G1/S transition checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in G2/M transition checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072396
name: response to cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0072405
alt_id: GO:0072408
def: "A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "cell cycle checkpoint effector process" EXACT [GOC:mah]
synonym: "G1/S transition checkpoint effector process" RELATED [GOC:mah]
synonym: "G2/M transition checkpoint effector process" RELATED [GOC:mah]
synonym: "response to G1/S transition checkpoint signaling" RELATED []
synonym: "response to G2/M transition checkpoint signaling" RELATED []
synonym: "response to signal involved in cell cycle checkpoint" EXACT [GOC:mah]
synonym: "response to signal involved in G1/S transition checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in G2/M transition checkpoint" RELATED [GOC:mah]
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0072397
name: obsolete detection of stimulus involved in cytokinesis checkpoint
namespace: biological_process
alt_id: GO:0072418
def: "OBSOLETE. The series of events in which information about the formation and integrity of cytokinetic structures, such as the contractile ring, is received and converted into a molecular signal, contributing to a cytokinesis checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "cytokinesis checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cytokinesis checkpoint sensor process" RELATED [GOC:mah]
synonym: "detection of stimulus involved in septin checkpoint" RELATED []
synonym: "sensing involved in cytokinesis checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in septin checkpoint" RELATED [GOC:mah]
synonym: "septin checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "septin checkpoint sensor process" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072398
name: signal transduction involved in cytokinesis checkpoint
namespace: biological_process
alt_id: GO:0072419
def: "A signal transduction process that contributes to a cytokinesis checkpoint." [GOC:mtg_cell_cycle]
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling

[Term]
id: GO:0072399
name: response to cytokinesis checkpoint signaling
namespace: biological_process
alt_id: GO:0072420
def: "A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "cytokinesis checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in cytokinesis checkpoint" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling

[Term]
id: GO:0072400
name: obsolete detection of stimulus involved in mitotic DNA integrity checkpoint
namespace: biological_process
alt_id: GO:0072457
def: "OBSOLETE. The series of events in which information about DNA integrity is received and converted into a molecular signal, contributing to a mitotic DNA integrity checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in mitotic G2/M transition decatenation checkpoint" RELATED []
synonym: "DNA integrity checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "DNA integrity checkpoint sensor process" RELATED [GOC:mah]
synonym: "mitotic G2/M transition decatenation checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic G2/M transition decatenation checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in DNA integrity checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072402
name: response to DNA integrity checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "DNA integrity checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in DNA integrity checkpoint" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling

[Term]
id: GO:0072409
name: obsolete detection of stimulus involved in meiotic cell cycle checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a meiotic cell cycle checkpoint." [GOC:mah, GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "meiotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic cell cycle checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic cell cycle checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072410
name: response to meiotic cell cycle checkpoint signaling
namespace: biological_process
def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint." [GOC:mah]
synonym: "meiotic cell cycle checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic cell cycle checkpoint" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling

[Term]
id: GO:0072412
name: obsolete detection of stimulus involved in mitotic cell cycle checkpoint
namespace: biological_process
alt_id: GO:0072454
alt_id: GO:0072472
def: "OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in mitotic cell cycle G1/S checkpoint" RELATED []
synonym: "mitotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle checkpoint sensor process" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072414
name: response to mitotic cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0072455
alt_id: GO:0072473
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle checkpoint effector process" EXACT [GOC:mah]
synonym: "mitotic cell cycle G1/S checkpoint effector process" RELATED [GOC:mah]
synonym: "mitotic G2/M transition checkpoint effector process" RELATED [GOC:mah]
synonym: "response to mitotic cell cycle G1/S checkpoint signaling" RELATED []
synonym: "response to mitotic G2/M transition checkpoint signal" RELATED []
synonym: "response to signal involved in mitotic cell cycle checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in mitotic G2/M transition checkpoint" RELATED [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling

[Term]
id: GO:0072415
name: obsolete detection of stimulus involved in spindle checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about the assembly, orientation or integrity of the spindle is received and converted into a molecular signal, contributing to a spindle checkpoint." [GOC:mah, GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "sensing involved in spindle checkpoint" RELATED [GOC:mah]
synonym: "spindle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "spindle checkpoint sensor process" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072417
name: response to spindle checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of spindle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "response to signal involved in spindle checkpoint" EXACT [GOC:mah]
synonym: "spindle checkpoint effector process" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling

[Term]
id: GO:0072421
name: obsolete detection of DNA damage stimulus involved in DNA damage checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a DNA damage checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in DNA damage checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072423
name: response to DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072402 ! response to DNA integrity checkpoint signaling

[Term]
id: GO:0072426
name: response to G2 DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072423 ! response to DNA damage checkpoint signaling

[Term]
id: GO:0072427
name: obsolete detection of DNA damage stimulus involved in intra-S DNA damage checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to an intra-S DNA damage checkpoint." [GOC:mah]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "intra-S DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "intra-S DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in intra-S DNA damage checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072429
name: response to intra-S DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "intra-S DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in intra-S DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072423 ! response to DNA damage checkpoint signaling

[Term]
id: GO:0072430
name: obsolete detection of DNA damage stimulus involved in mitotic G1 DNA damage checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of DNA damage stimulus involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT []
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle G1/S transition DNA damage checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072432
name: response to G1 DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072423 ! response to DNA damage checkpoint signaling

[Term]
id: GO:0072433
name: obsolete detection of DNA damage stimulus involved in mitotic G2 DNA damage checkpoint
namespace: biological_process
alt_id: GO:0072424
def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of DNA damage stimulus involved in G2 DNA damage checkpoint" RELATED []
synonym: "detection of DNA damage stimulus involved in G2/M transition DNA damage checkpoint" RELATED []
synonym: "detection of DNA damage stimulus involved in mitotic G2/M transition DNA damage checkpoint" EXACT []
synonym: "G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in G2/M transition DNA damage checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in mitotic G2/M transition DNA damage checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072435
name: response to mitotic G2 DNA damage checkpoint signaling
namespace: biological_process
alt_id: GO:0072458
def: "A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic G2/M transition decatenation checkpoint effector process" RELATED [GOC:mah]
synonym: "mitotic G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic G2/M transition decatenation checkpoint signaling" RELATED []
synonym: "response to mitotic G2/M transition DNA damage checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072426 ! response to G2 DNA damage checkpoint signaling

[Term]
id: GO:0072436
name: obsolete detection of stimulus involved in DNA replication checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a DNA replication checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "DNA replication checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "DNA replication checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in DNA replication checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072438
name: response to DNA replication checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "DNA replication checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in DNA replication checkpoint" EXACT [GOC:mah]
is_a: GO:0072402 ! response to DNA integrity checkpoint signaling

[Term]
id: GO:0072439
name: obsolete detection of stimulus involved in meiotic DNA replication checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a meiotic DNA replication checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "meiotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic DNA replication checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic DNA replication checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072441
name: response to meiotic DNA replication checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "meiotic DNA replication checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic DNA replication checkpoint" EXACT [GOC:mah]
is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling
is_a: GO:0072438 ! response to DNA replication checkpoint signaling

[Term]
id: GO:0072442
name: obsolete detection of stimulus involved in mitotic DNA replication checkpoint
namespace: biological_process
alt_id: GO:0072445
def: "OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in S-M checkpoint" RELATED []
synonym: "mitotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic DNA replication checkpoint sensor process" RELATED [GOC:mah]
synonym: "S-M checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "S-M checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic DNA replication checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in S-M checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072444
name: response to mitotic DNA replication checkpoint signaling
namespace: biological_process
alt_id: GO:0072447
def: "A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic DNA replication checkpoint effector process" EXACT [GOC:mah]
synonym: "response to S-M checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic DNA replication checkpoint" EXACT [GOC:mah]
synonym: "response to signal involved in S-M checkpoint" EXACT [GOC:mah]
synonym: "S-M checkpoint effector process" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072438 ! response to DNA replication checkpoint signaling

[Term]
id: GO:0072448
name: obsolete detection of stimulus involved in G1 cell size control checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED []
synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072449
name: response to G1 cell size control checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G1/S transition size control checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in mitotic cell cycle G1/S transition size control checkpoint" EXACT [GOC:mah]
is_a: GO:0072470 ! response to cell size control checkpoint signaling

[Term]
id: GO:0072451
name: obsolete detection of stimulus involved in G2 cell size control checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a G2/M transition size control checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in G2/M transition size control checkpoint" EXACT []
synonym: "detection of stimulus involved in mitotic cell cycle G2/M transition size control checkpoint" RELATED [GOC:mah]
synonym: "G2/M transition size control checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "G2/M transition size control checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in G2/M transition size control checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072452
name: response to G2 transition size control checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "G2/M transition size control checkpoint effector process" EXACT [GOC:mah]
synonym: "response to G2/M transition size control checkpoint signaling" EXACT []
synonym: "response to mitotic cell cycle G2/M transition size control checkpoint signaling" EXACT [GOC:mah]
synonym: "response to signal involved in G2/M transition size control checkpoint" EXACT [GOC:mah]
is_a: GO:0072470 ! response to cell size control checkpoint signaling

[Term]
id: GO:0072460
name: obsolete detection of stimulus involved in meiotic recombination checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether recombination is complete is received and converted into a molecular signal, contributing to a meiotic recombination checkpoint." [GOC:mah]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "meiotic recombination checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic recombination checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic recombination checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072461
name: response to meiotic recombination checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "meiotic recombination checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic recombination checkpoint" EXACT [GOC:mah]
is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0051598 ! meiotic recombination checkpoint signaling

[Term]
id: GO:0072463
name: obsolete detection of stimulus involved in meiotic spindle assembly checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether spindle is correctly assembled and chromosomes are attached to the spindle is received and converted into a molecular signal, contributing to a meiotic spindle assembly checkpoint." [GOC:mah]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "meiotic spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic spindle assembly checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic spindle assembly checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072464
name: response to meiotic spindle assembly checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "meiotic spindle assembly checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic spindle assembly checkpoint" EXACT [GOC:mah]
is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling
is_a: GO:0072485 ! response to spindle assembly checkpoint signaling

[Term]
id: GO:0072466
name: obsolete detection of stimulus involved in cell shape checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about aspects of cell polarity control is received and converted into a molecular signal, contributing to a cell shape checkpoint." [GOC:mah, GOC:mtg_cell_cycle]
comment: This term was made obsolete because it was ambiguous.
synonym: "cell shape checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cell shape checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in cell shape checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072467
name: obsolete response to cell shape checkpoint signaling
namespace: biological_process
def: "OBSOLETE. A process that occurs in response to signals generated as a result of cell shape checkpoint signaling." [GOC:mtg_cell_cycle]
comment: This term was made obsolete because it was ambiguous.
synonym: "cell shape checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in cell shape checkpoint" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072468
name: obsolete signal transduction involved in cell shape checkpoint
namespace: biological_process
def: "OBSOLETE. A signal transduction process that contributes to a cell shape checkpoint." [GOC:mah]
comment: This term was made obsolete because it was ambiguous.
is_obsolete: true

[Term]
id: GO:0072469
name: obsolete detection of stimulus involved in cell size control checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a cell size control checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "cell size control checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cell size control checkpoint sensor process" RELATED [GOC:mah]
synonym: "detection of stimulus involved in mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah]
synonym: "sensing involved in cell size control checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072470
name: response to cell size control checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of cell size control checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "cell size control checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic cell cycle cell size control checkpoint signaling" EXACT [GOC:mah]
synonym: "response to signal involved in cell size control checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling

[Term]
id: GO:0072475
name: obsolete detection of stimulus involved in mitotic spindle checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in mitotic cell cycle spindle checkpoint" EXACT []
synonym: "mitotic cell cycle spindle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle spindle checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle spindle checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072476
name: response to mitotic spindle checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle spindle checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic cell cycle spindle checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic cell cycle spindle checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072417 ! response to spindle checkpoint signaling

[Term]
id: GO:0072478
name: obsolete detection of stimulus involved in mitotic spindle assembly checkpoint
namespace: biological_process
alt_id: GO:1902419
def: "OBSOLETE. The series of events in which information about whether the spindle is correctly assembled, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle assembly checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in Dma1-dependent checkpoint" NARROW []
synonym: "detection of stimulus involved in mitotic cell cycle spindle assembly checkpoint" EXACT []
synonym: "detection of stimulus involved in SAC-independent checkpoint" EXACT [GOC:TermGenie]
synonym: "mitotic cell cycle spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle spindle assembly checkpoint sensor process" RELATED [GOC:mah]
synonym: "perception of stimulus involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "perception of stimulus involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
synonym: "sensing involved in mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:mah]
synonym: "stimulus detection involved in DMA1-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "stimulus detection involved in SAC-independent checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus sensing involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:0072479
name: response to mitotic cell cycle spindle assembly checkpoint signaling
namespace: biological_process
alt_id: GO:0044811
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle spindle assembly checkpoint effector process" EXACT [GOC:mah]
synonym: "response to Dma1-dependent checkpoint signaling" NARROW []
synonym: "response to Dma1-dependent checkpoint signalling" NARROW []
synonym: "response to signal involved in mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:mah]
is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling
is_a: GO:0072485 ! response to spindle assembly checkpoint signaling

[Term]
id: GO:0072481
name: obsolete detection of stimulus involved in mitotic spindle orientation checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether the spindle is correctly oriented is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle orientation checkpoint." [GOC:mtg_cell_cycle]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in mitotic cell cycle spindle orientation checkpoint" EXACT []
synonym: "mitotic cell cycle spindle orientation checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle spindle orientation checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle spindle orientation checkpoint" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072482
name: response to mitotic cell cycle spindle orientation checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle spindle orientation checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in mitotic cell cycle spindle orientation checkpoint" EXACT [GOC:mah]
is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling

[Term]
id: GO:0072484
name: obsolete detection of stimulus involved in spindle assembly checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about spindle assembly is received and converted into a molecular signal, contributing to a spindle assembly checkpoint." [GOC:mah]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "sensing involved in spindle assembly checkpoint" RELATED [GOC:mah]
synonym: "spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "spindle assembly checkpoint sensor process" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072485
name: response to spindle assembly checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "response to signal involved in spindle assembly checkpoint" EXACT [GOC:mah]
synonym: "spindle assembly checkpoint effector process" EXACT [GOC:mah]
is_a: GO:0072417 ! response to spindle checkpoint signaling

[Term]
id: GO:0072487
name: MSL complex
namespace: cellular_component
def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]
is_a: GO:1902562 ! H4 histone acetyltransferase complex

[Term]
id: GO:0072488
name: ammonium transmembrane transport
namespace: biological_process
alt_id: GO:0015696
def: "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ammonia transport" BROAD []
synonym: "ammonium membrane transport" EXACT []
synonym: "ammonium transport" BROAD []
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0072489
name: methylammonium transmembrane transport
namespace: biological_process
def: "The process in which methylammonium is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "methylammonium membrane transport" EXACT []
is_a: GO:0015843 ! methylammonium transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0072490
name: toluene-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives." [GOC:mah]
synonym: "toluene and derivative metabolic process" EXACT [GOC:mah]
synonym: "toluene-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0072491
name: toluene-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives." [GOC:mah]
synonym: "toluene and derivative catabolic process" EXACT [GOC:mah]
synonym: "toluene-containing compound breakdown" EXACT [GOC:mah]
synonym: "toluene-containing compound catabolism" EXACT [GOC:mah]
synonym: "toluene-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0009056 ! catabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0072492
name: host cell mitochondrial intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope." [GOC:ecd]
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044190 ! host cell mitochondrial envelope

[Term]
id: GO:0072493
name: host cell endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the host cell endosome." [GOC:ecd]
synonym: "host endosome lumen" EXACT [GOC:mah]
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044174 ! host cell endosome

[Term]
id: GO:0072494
name: host multivesicular body
namespace: cellular_component
def: "A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm." [GOC:rph]
synonym: "host cell multivesicular body" EXACT [GOC:mah]
is_a: GO:0044184 ! host cell late endosome

[Term]
id: GO:0072495
name: host cell Cajal body
namespace: cellular_component
def: "A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:rph]
synonym: "coiled body of host" EXACT [GOC:rph]
synonym: "host cell coiled body" EXACT [GOC:mah]
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0044095 ! host cell nucleoplasm

[Term]
id: GO:0072496
name: Pup transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages." [GOC:sp]
synonym: "Pup conjugating enzyme activity" NARROW [GOC:mah]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0072497
name: mesenchymal stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF]
is_a: GO:0048863 ! stem cell differentiation

[Term]
id: GO:0072498
name: embryonic skeletal joint development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure." [GOC:BHF, GOC:vk]
is_a: GO:0048706 ! embryonic skeletal system development

[Term]
id: GO:0072499
name: photoreceptor cell axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
synonym: "photoreceptor cell axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0072500
name: obsolete negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
namespace: biological_process
def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:mah]
comment: This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand.
synonym: "negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0003713
consider: GO:0004879
consider: GO:0030522

[Term]
id: GO:0072501
name: obsolete cellular divalent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0030002

[Term]
id: GO:0072502
name: obsolete cellular trivalent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0030002

[Term]
id: GO:0072503
name: obsolete cellular divalent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0030003

[Term]
id: GO:0072504
name: obsolete cellular trivalent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0030003

[Term]
id: GO:0072505
name: obsolete divalent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell." [GOC:mah]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0055081

[Term]
id: GO:0072506
name: obsolete trivalent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0055081

[Term]
id: GO:0072507
name: obsolete divalent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0055080

[Term]
id: GO:0072508
name: obsolete trivalent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0055080

[Term]
id: GO:0072513
name: positive regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "negative regulation of second heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0003266 ! regulation of secondary heart field cardioblast proliferation
is_a: GO:0008284 ! positive regulation of cell population proliferation

[Term]
id: GO:0072514
name: trehalose transport in response to water deprivation
namespace: biological_process
def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water." [GOC:mah]
is_a: GO:0015771 ! trehalose transport
relationship: part_of GO:0042631 ! cellular response to water deprivation

[Term]
id: GO:0072515
name: trehalose transport in response to desiccation
namespace: biological_process
def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water." [GOC:mah]
is_a: GO:0072514 ! trehalose transport in response to water deprivation
relationship: part_of GO:0071465 ! cellular response to desiccation

[Term]
id: GO:0072517
name: host cell viral assembly compartment
namespace: cellular_component
alt_id: GO:0072516
def: "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place." [GOC:BHF, PMID:20374631]
synonym: "host cell viral assembly site" RELATED [GOC:BHF]
synonym: "host cell virion assembly compartment" EXACT [GOC:mah]
synonym: "viral assembly compartment" EXACT []
synonym: "viral assembly site" RELATED []
synonym: "virion assembly compartment" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0039714 ! cytoplasmic viral factory

[Term]
id: GO:0072518
name: Rho-dependent protein serine/threonine kinase activity
namespace: molecular_function
def: "Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:ecd, PMID:12778124, PMID:20230755]
comment: This reaction requires binding of the GTPase Rho.
synonym: "Rho-associated protein kinase activity" EXACT [GOC:ecd]
synonym: "ROCK kinase activity" EXACT [GOC:ecd]
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0072520
name: seminiferous tubule development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa." [GOC:BHF, GOC:mah, UBERON:0001343]
is_a: GO:0035295 ! tube development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0072521
name: purine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]
synonym: "purine and derivative metabolic process" EXACT []
synonym: "purine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0072522
name: purine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]
synonym: "purine and derivative biosynthetic process" EXACT []
synonym: "purine-containing compound anabolism" EXACT [GOC:mah]
synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah]
synonym: "purine-containing compound formation" EXACT [GOC:mah]
synonym: "purine-containing compound synthesis" EXACT [GOC:mah]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0072523
name: purine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]
synonym: "purine and derivative catabolic process" EXACT []
synonym: "purine-containing compound breakdown" EXACT [GOC:mah]
synonym: "purine-containing compound catabolism" EXACT [GOC:mah]
synonym: "purine-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0009056 ! catabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0072524
name: pyridine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]
synonym: "pyridine and derivative metabolic process" EXACT []
synonym: "pyridine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0072525
name: pyridine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]
synonym: "pyridine and derivative biosynthetic process" EXACT []
synonym: "pyridine-containing compound anabolism" EXACT [GOC:mah]
synonym: "pyridine-containing compound biosynthesis" EXACT [GOC:mah]
synonym: "pyridine-containing compound formation" EXACT [GOC:mah]
synonym: "pyridine-containing compound synthesis" EXACT [GOC:mah]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0072526
name: pyridine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]
synonym: "pyridine and derivative catabolic process" EXACT []
synonym: "pyridine-containing compound breakdown" EXACT [GOC:mah]
synonym: "pyridine-containing compound catabolism" EXACT [GOC:mah]
synonym: "pyridine-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0009056 ! catabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0072527
name: pyrimidine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]
synonym: "pyrimidine and derivative metabolic process" EXACT []
synonym: "pyrimidine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0072528
name: pyrimidine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]
synonym: "pyrimidine and derivative biosynthetic process" EXACT []
synonym: "pyrimidine-containing compound anabolism" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound biosynthesis" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound formation" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound synthesis" EXACT [GOC:mah]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0072529
name: pyrimidine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]
synonym: "pyrimidine and derivative catabolic process" EXACT []
synonym: "pyrimidine-containing compound breakdown" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound catabolism" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0009056 ! catabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0072530
name: purine-containing compound transmembrane transport
namespace: biological_process
def: "The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "purine-containing compound membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0072531
name: pyrimidine-containing compound transmembrane transport
namespace: biological_process
def: "The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "pyrimidine-containing compound membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0072532
name: tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives." [GOC:kad, PMID:19779199]
comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-triferuloyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tri-(hydroxyferuloyl)-spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11262 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11262) and the KEGG reaction R08986 (http://www.genome.jp/dbget-bin/www_bget?rn:R08986).
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0072533
name: tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives." [GOC:kad, PMID:19779199]
comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-tricoumaroyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tricaffeoyl spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11260 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11260).
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0072534
name: perineuronal net
namespace: cellular_component
def: "A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain." [GOC:sl, PMID:18364019]
synonym: "PNN" EXACT [GOC:sl]
is_a: GO:0098966 ! perisynaptic extracellular matrix

[Term]
id: GO:0072535
name: tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "RANKL production" EXACT [GOC:ebc, PR:000002107]
synonym: "TNFSF11 production" EXACT [GOC:mah, PR:000002107]
synonym: "tumor necrosis factor ligand superfamily member 11 production" EXACT [GOC:bf, PR:000002107]
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0072536
name: interleukin-23 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits." [GOC:BHF, GOC:mah, PMID:12023369]
synonym: "IL-23 receptor complex" EXACT [GOC:mah]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0072537
name: fibroblast activation
namespace: biological_process
def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0072538
name: T-helper 17 type immune response
namespace: biological_process
def: "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22." [GOC:BHF, GOC:ebc]
synonym: "Th17 immune response" EXACT [GOC:mah]
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0072539
name: T-helper 17 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T-helper 17 cell development" RELATED [GOC:mah]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0072538 ! T-helper 17 type immune response

[Term]
id: GO:0072540
name: T-helper 17 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc]
synonym: "T-helper 17 cell fate commitment" EXACT [GOC:mah]
synonym: "Th17 cell lineage commitment" EXACT [CL:0000899, GOC:mah]
synonym: "Th17 fate commitment" EXACT [CL:0000899]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0072539 ! T-helper 17 cell differentiation

[Term]
id: GO:0072541
name: peroxynitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: [protein]-dithiol + ONOO- = [protein]-disulfide + NO2- + H2O." [GOC:rs, PMID:11001062]
comment: Note that this activity is usually associated in vivo with an NADPH-dependent disulfide reductase activity, so that catalysis of the reduction of peroxynitrite to nitrite involves the possible creation of oxygen or water, using NADPH as reduction equivalent.
synonym: "peroxynitritase activity" EXACT [GOC:rs]
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0072542
name: protein phosphatase activator activity
namespace: molecular_function
alt_id: GO:0071862
alt_id: GO:0072543
def: "Binds to and increases the activity of a protein phosphatase." [GOC:mah]
synonym: "protein phosphatase 2 activator activity" NARROW [GOC:dph, GOC:rl]
synonym: "protein phosphatase type 1 activator activity" NARROW []
synonym: "protein phosphatase type 2A activator activity" NARROW []
is_a: GO:0019211 ! phosphatase activator activity
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0072544
name: L-DOPA binding
namespace: molecular_function
def: "Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid." [GOC:mah, GOC:vw]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0072545
name: L-tyrosine binding
namespace: molecular_function
def: "Binding to L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:mah]
synonym: "L-Tyr binding" EXACT [GOC:mah]
synonym: "tyrosine binding" BROAD []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0072546
name: EMC complex
namespace: cellular_component
def: "A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]
comment: Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect.
synonym: "endoplasmic reticulum membrane protein complex" BROAD []
synonym: "ER membrane protein complex" BROAD [GOC:mah]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0072547
name: tricoumaroylspermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
synonym: "tricoumaroyl spermidine meta-hydroxylase activity" EXACT [GOC:mah]
xref: MetaCyc:RXN-11260
is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity

[Term]
id: GO:0072548
name: dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity

[Term]
id: GO:0072549
name: monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity

[Term]
id: GO:0072550
name: triferuloylspermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
synonym: "triferuloyl spermidine meta-hydroxylase activity" EXACT [GOC:mah]
xref: MetaCyc:RXN-11262
is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity

[Term]
id: GO:0072551
name: diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity

[Term]
id: GO:0072552
name: monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity

[Term]
id: GO:0072553
name: terminal button organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah]
synonym: "bouton organization" EXACT [GOC:mah]
synonym: "presynaptic bouton organization" EXACT [GOC:mah]
synonym: "synaptic bouton organization" EXACT [GOC:mah]
synonym: "terminal bouton organization" EXACT [GOC:mah]
synonym: "terminal button organisation" EXACT [GOC:mah]
is_a: GO:0099172 ! presynapse organization

[Term]
id: GO:0072554
name: blood vessel lumenization
namespace: biological_process
def: "The process in which a developing blood vessel forms an endothelial lumen through which blood will flow." [GOC:dsf, PMID:16799567, PMID:20926893]
is_a: GO:0061154 ! endothelial tube morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0072555
name: obsolete 17-beta-ketosteroid reductase (NADPH) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+." [GOC:kad, PMID:17074428]
comment: This term was obsoleted because it was an unnecessary grouoing term.
synonym: "7beta-ketosteroid reductase activity" EXACT [GOC:kad]
is_obsolete: true
consider: GO:0072582

[Term]
id: GO:0072557
name: IPAF inflammasome complex
namespace: cellular_component
def: "An inflammasome complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]
is_a: GO:0061702 ! canonical inflammasome complex

[Term]
id: GO:0072558
name: NLRP1 inflammasome complex
namespace: cellular_component
def: "An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]
synonym: "NALP1 inflammasome complex" EXACT []
is_a: GO:0061702 ! canonical inflammasome complex

[Term]
id: GO:0072559
name: NLRP3 inflammasome complex
namespace: cellular_component
def: "An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]
synonym: "NALP3 inflammasome complex" EXACT []
is_a: GO:0061702 ! canonical inflammasome complex

[Term]
id: GO:0072560
name: type B pancreatic cell maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF]
comment: These processes continue to 60 DPA in Gossypium spp.
synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah]
synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah]
is_a: GO:0002071 ! glandular epithelial cell maturation
relationship: part_of GO:0003323 ! type B pancreatic cell development

[Term]
id: GO:0072562
name: blood microparticle
namespace: cellular_component
def: "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids." [GOC:BHF, GOC:mah, PMID:16373184]
synonym: "cell membrane microparticle" EXACT [PMID:16373184]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0072563
name: endothelial microparticle
namespace: cellular_component
def: "A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184]
is_a: GO:0072562 ! blood microparticle

[Term]
id: GO:0072564
name: blood microparticle formation
namespace: biological_process
def: "The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell." [GOC:BHF, GOC:mah, PMID:16373184]
synonym: "microparticle generation" EXACT [PMID:20978343]
synonym: "microparticle release" EXACT [PMID:16373184]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0072565
name: endothelial microparticle formation
namespace: biological_process
def: "The cellular component organization process in which microparticles bud off from an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184]
synonym: "endothelial microparticle generation" EXACT [GOC:mah, PMID:20978343]
synonym: "endothelial microparticle release" EXACT [GOC:mah, PMID:16373184]
is_a: GO:0072564 ! blood microparticle formation

[Term]
id: GO:0072566
name: chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CXCL1 production" EXACT [GOC:BHF]
synonym: "KC production" EXACT [GOC:BHF]
synonym: "keratinocyte derived chemokine production" EXACT [GOC:BHF]
synonym: "SCYB1 production" EXACT [GOC:BHF]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0072567
name: chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CXCL2 production" EXACT [GOC:mah]
synonym: "MIP-2 production" EXACT [GOC:BHF]
synonym: "MIP2 production" EXACT [GOC:BHF]
synonym: "SCYB2 production" EXACT [GOC:BHF]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0072570
name: ADP-D-ribose binding
namespace: molecular_function
def: "Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [GOC:mah, GOC:sart, PMID:20088964]
synonym: "ADP-ribose binding" BROAD [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding
is_a: GO:1901265 ! nucleoside phosphate binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0072571
name: mono-ADP-D-ribose binding
namespace: molecular_function
def: "Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [GOC:mah, GOC:sart, PMID:20088964]
synonym: "mADPr binding" EXACT [PMID:20088964]
synonym: "mono-ADP-ribose binding" BROAD [GOC:mah]
is_a: GO:0072570 ! ADP-D-ribose binding

[Term]
id: GO:0072572
name: poly-ADP-D-ribose binding
namespace: molecular_function
def: "Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]
synonym: "pADPr binding" EXACT [PMID:20088964]
synonym: "poly-ADP-ribose binding" BROAD [GOC:mah]
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0072573
name: tolerance induction to lipopolysaccharide
namespace: biological_process
def: "Tolerance induction directed at lipopolysaccharide antigens." [GOC:BHF, GOC:mah]
synonym: "tolerance induction to endotoxin" BROAD [GOC:add, GOC:mah]
synonym: "tolerance induction to LPS" EXACT [GOC:add, GOC:mah]
is_a: GO:0002507 ! tolerance induction
is_a: GO:0031665 ! negative regulation of lipopolysaccharide-mediated signaling pathway
relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide

[Term]
id: GO:0072574
name: hepatocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules." [CL:0000182, GOC:BHF, GOC:mah]
is_a: GO:0072575 ! epithelial cell proliferation involved in liver morphogenesis

[Term]
id: GO:0072575
name: epithelial cell proliferation involved in liver morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0072576 ! liver morphogenesis

[Term]
id: GO:0072576
name: liver morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0072577
name: endothelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptosis of endothelial cells" EXACT [GOC:mah]
synonym: "endothelial cell apoptosis" NARROW []
synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "killing of endothelial cells" EXACT [GOC:mah]
synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah]
synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah]
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0072578
name: neurotransmitter-gated ion channel clustering
namespace: biological_process
def: "The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane." [GOC:dsf, PMID:20843816]
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0072579
name: glycine receptor clustering
namespace: biological_process
def: "The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane." [GOC:dsf, GOC:mah, GOC:pr, PMID:20843816]
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:0072580
name: bacterial-type EF-P lysine modification
namespace: biological_process
def: "The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P)." [GOC:curators, GOC:imk, GOC:mah, PMID:20729861, PMID:22706199, RESID:AA0530, RESID:AA0531]
comment: The EF-P modification pathway is now thought to be composed of three steps: conversion of alpha-lysyl-EF-P to beta-lysyl-EF-P, lysylation of Lys34, and hydroxylation of Lys34.
subset: gocheck_obsoletion_candidate
synonym: "EF-P modification pathway" EXACT [PMID:22706199]
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0072581
name: obsolete protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine
namespace: biological_process
def: "OBSOLETE. The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:jsg, GOC:mah, PMID:20729861, RESID:AA0531]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0072582
name: 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+." [GOC:kad, PMID:17074428]
xref: RHEA:69284
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0072583
name: clathrin-dependent endocytosis
namespace: biological_process
def: "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
synonym: "clathrin coated pit-dependent endocytosis" EXACT [GOC:BHF]
synonym: "clathrin-mediated endocytosis" EXACT []
synonym: "CME" EXACT [PMID:20074057]
is_a: GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0072584
name: caveolin-mediated endocytosis
namespace: biological_process
def: "An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers." [GOC:BHF, GOC:mah, PMID:17318224, PMID:18498251, PMID:8970738, PMID:9234965]
synonym: "caveolae-dependent endocytosis" EXACT [GOC:mah]
synonym: "caveolae-mediated endocytosis" EXACT [GOC:mah]
synonym: "caveolin-dependent endocytosis" EXACT [GOC:BHF]
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0072585
name: xanthosine nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine." [GOC:kad, MetaCyc:RXN0-363, PMID:21235647]
synonym: "xanthosine ribohydrolase activity" EXACT [GOC:kad]
xref: MetaCyc:RXN0-363
xref: RHEA:27994
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0072586
name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
is_a: GO:0030234 ! enzyme regulator activity
is_a: GO:0060590 ! ATPase regulator activity

[Term]
id: GO:0072587
name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity
namespace: molecular_function
def: "Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
is_a: GO:0001671 ! ATPase activator activity
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0072586 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity

[Term]
id: GO:0072588
name: box H/ACA RNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex." [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:krc, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365, PMID:25590339]
synonym: "box H/ACA snoRNP pseudouridylase complex" RELATED [GOC:mah]
synonym: "sRNP complex" NARROW [GOC:mah, PMID:17284456, PMID:20227365]
is_a: GO:0005732 ! sno(s)RNA-containing ribonucleoprotein complex

[Term]
id: GO:0072589
name: box H/ACA scaRNP complex
namespace: cellular_component
def: "A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs." [GOC:mah, PMID:17284456, PMID:20227365]
synonym: "nucleoplasmic box H/ACA RNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:20227365]
is_a: GO:0072588 ! box H/ACA RNP complex
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0015030 ! Cajal body

[Term]
id: GO:0072590
name: N-acetyl-L-aspartate-L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate." [PMID:20643647, PMID:20657015]
xref: Reactome:R-HSA-8942575 "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG"
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0072591
name: citrate-L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate." [PMID:20657015]
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0072592
name: oxygen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah]
synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263]
synonym: "oxygen metabolism" EXACT [GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0072593
name: reactive oxygen species metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah]
synonym: "reactive oxygen species metabolism" EXACT [GOC:mah]
synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0072594
name: establishment of protein localization to organelle
namespace: biological_process
def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]
synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
is_a: GO:0045184 ! establishment of protein localization

[Term]
id: GO:0072595
name: maintenance of protein localization in organelle
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]
synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah]
synonym: "maintenance of protein localization to organelle" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0033365 ! protein localization to organelle

[Term]
id: GO:0072596
name: establishment of protein localization to chloroplast
namespace: biological_process
def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah]
synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:0072598 ! protein localization to chloroplast

[Term]
id: GO:0072597
name: maintenance of protein location in chloroplast
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072595 ! maintenance of protein localization in organelle
relationship: part_of GO:0072598 ! protein localization to chloroplast

[Term]
id: GO:0072598
name: protein localization to chloroplast
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd]
synonym: "protein localisation to chloroplast" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0072599
name: establishment of protein localization to endoplasmic reticulum
namespace: biological_process
def: "The directed movement of a protein to a specific location in the endoplasmic reticulum." [GOC:mah]
synonym: "establishment of protein localisation to endoplasmic reticulum" EXACT [GOC:mah]
synonym: "establishment of protein localisation to ER" EXACT [GOC:mah]
synonym: "establishment of protein localization in endoplasmic reticulum" EXACT []
synonym: "establishment of protein localization to ER" EXACT [GOC:mah]
is_a: GO:0070972 ! protein localization to endoplasmic reticulum
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0072627
name: interleukin-28A production
namespace: biological_process
alt_id: GO:0072628
def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IL-28A production" EXACT [GOC:BHF]
synonym: "IL28A production" EXACT [GOC:BHF]
synonym: "interferon lambda 2 production" EXACT [GOC:BHF]
synonym: "interleukin-28A secretion" NARROW []
is_a: GO:0034343 ! type III interferon production

[Term]
id: GO:0072629
name: interleukin-28B production
namespace: biological_process
alt_id: GO:0072630
def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IL-28B production" EXACT [GOC:BHF]
synonym: "IL28B production" EXACT [GOC:BHF]
synonym: "interferon lambda 3 production" EXACT [GOC:BHF]
synonym: "interleukin-28B secretion" NARROW []
is_a: GO:0034343 ! type III interferon production

[Term]
id: GO:0072631
name: interleukin-29 production
namespace: biological_process
alt_id: GO:0072632
def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IL-29 production" EXACT [GOC:BHF]
synonym: "IL29 production" EXACT [GOC:BHF]
synonym: "interferon lambda 1 production" EXACT [GOC:BHF]
synonym: "interleukin-29 secretion" NARROW []
is_a: GO:0034343 ! type III interferon production

[Term]
id: GO:0072633
name: interleukin-30 production
namespace: biological_process
alt_id: GO:0072634
def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:30328794]
subset: gocheck_do_not_annotate
synonym: "IL-30 production" EXACT [GOC:BHF]
synonym: "interleukin-30 complex production" EXACT [GOC:BHF]
synonym: "interleukin-30 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072635
name: interleukin-31 production
namespace: biological_process
alt_id: GO:0072636
def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:30328794]
subset: gocheck_do_not_annotate
synonym: "IL-31 production" EXACT [GOC:BHF]
synonym: "interleukin-31 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072637
name: interleukin-32 production
namespace: biological_process
alt_id: GO:0072638
alt_id: GO:0150188
def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:23729669]
subset: gocheck_do_not_annotate
synonym: "IL-32 production" EXACT [GOC:BHF]
synonym: "IL32 production" EXACT [GOC:BHF]
synonym: "interleukin-32 biosynthetic process" NARROW []
synonym: "interleukin-32 secretion" NARROW []
synonym: "NK4 production" NARROW [GOC:BHF]
synonym: "TAIF production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072639
name: interleukin-33 production
namespace: biological_process
alt_id: GO:0072640
alt_id: GO:0150126
def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:29778524]
subset: gocheck_do_not_annotate
synonym: "C9orf26 production" NARROW [GOC:BHF]
synonym: "IL-33 production" EXACT [GOC:BHF]
synonym: "IL1F11 production" NARROW [GOC:BHF]
synonym: "IL33 production" EXACT [GOC:BHF]
synonym: "interleukin-33 biosynthetic process" NARROW []
synonym: "interleukin-33 secretion" NARROW []
synonym: "NF-HEV production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072645
name: interferon-delta production
namespace: biological_process
alt_id: GO:0072646
def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-delta production" EXACT [GOC:mah]
synonym: "IFND production" EXACT [GOC:BHF]
synonym: "interferon-delta secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072647
name: interferon-epsilon production
namespace: biological_process
alt_id: GO:0072648
def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-epsilon production" EXACT [GOC:mah]
synonym: "IFNE production" EXACT [GOC:BHF]
synonym: "interferon-epsilon secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072649
name: interferon-kappa production
namespace: biological_process
alt_id: GO:0072650
def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-kappa production" EXACT [GOC:mah]
synonym: "IFNK production" EXACT [GOC:BHF]
synonym: "interferon-kappa secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072651
name: interferon-tau production
namespace: biological_process
alt_id: GO:0072652
def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-tau production" EXACT [GOC:mah]
synonym: "IFN-tau secretion" EXACT [GOC:mah]
synonym: "IFNT production" EXACT [GOC:BHF]
synonym: "interferon-tau secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072653
name: interferon-omega production
namespace: biological_process
alt_id: GO:0072654
def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-omega production" EXACT [GOC:mah]
synonym: "IFNW production" EXACT [GOC:BHF]
synonym: "interferon-omega secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072655
name: establishment of protein localization to mitochondrion
namespace: biological_process
def: "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah]
synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrion" EXACT []
is_a: GO:0070585 ! protein localization to mitochondrion
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0072656
name: maintenance of protein location in mitochondrion
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072595 ! maintenance of protein localization in organelle
relationship: part_of GO:0070585 ! protein localization to mitochondrion

[Term]
id: GO:0072657
name: protein localization to membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]
subset: goslim_prokaryote
synonym: "protein localisation in membrane" EXACT [GOC:mah]
synonym: "protein localization in membrane" EXACT []
is_a: GO:0008104 ! protein localization
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0072658
name: maintenance of protein location in membrane
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0072657 ! protein localization to membrane

[Term]
id: GO:0072659
name: protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0072661
alt_id: GO:0090002
def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]
subset: goslim_generic
subset: goslim_pombe
synonym: "protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "protein localization in plasma membrane" RELATED []
synonym: "protein targeting to plasma membrane" RELATED []
synonym: "protein-plasma membrane targeting" RELATED [GOC:mah]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0072660
name: maintenance of protein location in plasma membrane
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072658 ! maintenance of protein location in membrane
relationship: part_of GO:0072659 ! protein localization to plasma membrane

[Term]
id: GO:0072662
name: protein localization to peroxisome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome." [GOC:ecd]
synonym: "protein localisation to peroxisome" EXACT [GOC:mah]
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0072663
name: establishment of protein localization to peroxisome
namespace: biological_process
def: "The directed movement of a protein to a specific location in a peroxisome." [GOC:mah]
synonym: "establishment of protein localisation to peroxisome" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:0072662 ! protein localization to peroxisome

[Term]
id: GO:0072664
name: maintenance of protein location in peroxisome
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072595 ! maintenance of protein localization in organelle
relationship: part_of GO:0072662 ! protein localization to peroxisome

[Term]
id: GO:0072665
name: protein localization to vacuole
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd]
synonym: "protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0072666
name: establishment of protein localization to vacuole
namespace: biological_process
def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah]
synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:0072665 ! protein localization to vacuole

[Term]
id: GO:0072667
name: maintenance of protein location in vacuole
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072595 ! maintenance of protein localization in organelle
relationship: part_of GO:0072665 ! protein localization to vacuole

[Term]
id: GO:0072668
name: obsolete tubulin complex biogenesis
namespace: biological_process
def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a tubulin complex. Includes the synthesis and folding of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. A tubulin complex is a heterodimer of tubulins alpha and beta, from which microtubules are assembled." [GOC:mah]
comment: This term was obsoleted because biogenesis should only be used for complexes where synthesis of some non-protein component is necessary for assembly.
synonym: "tubulin complex biogenesis" EXACT []
is_obsolete: true
replaced_by: GO:0007021

[Term]
id: GO:0072669
name: tRNA-splicing ligase complex
namespace: cellular_component
def: "A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]
synonym: "tRNA splicing ligase complex" EXACT [GOC:mah]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0072670
name: mitochondrial tRNA threonylcarbamoyladenosine modification
namespace: biological_process
def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base)." [GOC:mcc, PMID:21183954]
synonym: "mitochondrial tRNA t6A modification" EXACT [GOC:mcc]
is_a: GO:0002949 ! tRNA threonylcarbamoyladenosine modification
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0072671
name: mitochondria-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions." [GOC:mcc, PMID:21070972, PMID:21109188]
synonym: "MAD" EXACT [GOC:mcc]
synonym: "mitochondria-associated protein catabolic process" EXACT []
synonym: "mitochondria-associated protein degradation" EXACT [GOC:mcc]
synonym: "mitochondrion-associated protein catabolic process" EXACT [GOC:mah]
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0072672
name: neutrophil extravasation
namespace: biological_process
def: "The migration of a neutrophil from the blood vessels into the surrounding tissue." [CL:0000775, GOC:BHF]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:1990266 ! neutrophil migration

[Term]
id: GO:0072673
name: lamellipodium morphogenesis
namespace: biological_process
def: "A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized." [GOC:BHF, GOC:mah]
synonym: "lamellipodium organization" RELATED [GOC:mah]
is_a: GO:0097581 ! lamellipodium organization
is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis

[Term]
id: GO:0072674
name: multinuclear osteoclast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016]
synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah]
synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah]
is_a: GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0072675
name: osteoclast fusion
namespace: biological_process
def: "The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast." [CL:0000092, CL:0000779, GOC:BHF, GOC:mah, PMID:12713016]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: part_of GO:0072674 ! multinuclear osteoclast differentiation

[Term]
id: GO:0072676
name: lymphocyte migration
namespace: biological_process
def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah]
is_a: GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0072677
name: eosinophil migration
namespace: biological_process
def: "The movement of an eosinophil within or between different tissues and organs of the body." [CL:0000771, GOC:BHF, GOC:mah]
is_a: GO:0097530 ! granulocyte migration

[Term]
id: GO:0072678
name: T cell migration
namespace: biological_process
def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah]
synonym: "T lymphocyte migration" EXACT [CL:0000084]
synonym: "T-cell migration" EXACT [CL:0000084]
synonym: "T-lymphocyte migration" EXACT [CL:0000084]
is_a: GO:0072676 ! lymphocyte migration

[Term]
id: GO:0072679
name: thymocyte migration
namespace: biological_process
def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development." [CL:0000893, GOC:BHF, GOC:mah]
synonym: "immature T cell migration" RELATED [CL:0000893]
synonym: "immature T lymphocyte migration" RELATED [CL:0000893]
synonym: "immature T-cell migration" RELATED [CL:0000893]
synonym: "immature T-lymphocyte migration" RELATED [CL:0000893]
synonym: "thymic lymphocyte migration" EXACT [CL:0000893]
is_a: GO:0072678 ! T cell migration

[Term]
id: GO:0072680
name: extracellular matrix-dependent thymocyte migration
namespace: biological_process
def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819]
synonym: "extracellular matrix-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah]
is_a: GO:0006929 ! substrate-dependent cell migration
is_a: GO:0072679 ! thymocyte migration

[Term]
id: GO:0072681
name: fibronectin-dependent thymocyte migration
namespace: biological_process
def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819]
synonym: "fibronectin-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah]
is_a: GO:0072680 ! extracellular matrix-dependent thymocyte migration

[Term]
id: GO:0072682
name: eosinophil extravasation
namespace: biological_process
def: "The migration of an eosinophil from the blood vessels into the surrounding tissue." [CL:0000771, GOC:BHF, GOC:mah]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:0072677 ! eosinophil migration

[Term]
id: GO:0072683
name: T cell extravasation
namespace: biological_process
def: "The migration of a T cell from the blood vessels into the surrounding tissue." [CL:0000084, GOC:BHF, GOC:mah]
synonym: "T lymphocyte extravasation" EXACT [CL:0000084]
synonym: "T-cell extravasation" EXACT [CL:0000084]
synonym: "T-lymphocyte extravasation" EXACT [CL:0000084]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:0072678 ! T cell migration

[Term]
id: GO:0072684
name: obsolete mitochondrial tRNA 3'-trailer cleavage, endonucleolytic
namespace: biological_process
def: "OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah]
comment: he reason for obsoletion is that these term represent molecular functions.
synonym: "mitochondrial endonucleolytic tRNA 3'-end cleavage" EXACT [GOC:mah]
synonym: "mitochondrial endonucleolytic tRNA 3'-trailer cleavage" RELATED [GOC:mah]
synonym: "mitochondrial tRNA 3'-end cleavage, endonucleolytic" EXACT [GOC:mah]
is_obsolete: true
replaced_by: GO:1990180

[Term]
id: GO:0072685
name: Mre11 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling." [GOC:mah, PMID:19211838]
synonym: "MRN complex assembly" EXACT [GOC:mah]
synonym: "MRX complex assembly" EXACT [GOC:mah]
synonym: "Rad50 complex assembly" EXACT [GOC:mah]
synonym: "RAD50-MRE11-NBN complex assembly" EXACT [CORUM:2767, GOC:mah]
synonym: "Rad50-Rad32-Nbs1 complex assembly" EXACT [GOC:mah]
synonym: "RMX complex assembly" EXACT [GOC:mah]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0072686
name: mitotic spindle
namespace: cellular_component
def: "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
is_a: GO:0005819 ! spindle

[Term]
id: GO:0072687
name: meiotic spindle
namespace: cellular_component
def: "A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
is_a: GO:0005819 ! spindle

[Term]
id: GO:0072688
name: SHREC complex localization
namespace: biological_process
def: "Any process in which a SHREC complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of SHREC complex localization" EXACT [GOC:mah]
synonym: "SHREC complex localisation" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0072689
name: MCM complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:mah, PMID:21813639]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0072690
name: single-celled organism vegetative growth phase
namespace: biological_process
alt_id: GO:0062178
def: "A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods." [GOC:mah, GOV:vw]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "stationary phase" NARROW []
synonym: "vegetative growth of a single-celled organism" EXACT []
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0072692
name: obsolete chromatin silencing at centromere central core
namespace: biological_process
def: "OBSOLETE. Repression of transcription of DNA at the central core of a regional centromere by altering the structure of chromatin." [GOC:mah]
comment: This term was made obsolete because the process does not exist.
synonym: "centromere central core chromatin silencing" EXACT [GOC:mah]
synonym: "chromatin silencing at centromeric central core" EXACT [GOC:vw]
synonym: "chromatin silencing at chromosome kinetochore domain" EXACT [GOC:vw]
synonym: "heterochromatic silencing at centromere central core" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0072694
name: obsolete cell cycle arrest in response to caffeine
namespace: biological_process
def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a caffeine stimulus." [GOC:mah]
comment: This term was made obsolete because it does not represent a real process.
is_obsolete: true

[Term]
id: GO:0072695
name: regulation of DNA recombination at telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination within the telomere." [GOC:mah]
synonym: "regulation of telomeric recombination" EXACT [GOC:mah]
is_a: GO:0000018 ! regulation of DNA recombination

[Term]
id: GO:0072696
name: positive regulation of DNA recombination at telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination within the telomere." [GOC:mah]
synonym: "activation of telomeric recombination at telomere" NARROW [GOC:mah]
synonym: "positive regulation of telomeric recombination" EXACT [GOC:mah]
synonym: "up regulation of telomeric recombination at telomere" EXACT [GOC:mah]
synonym: "up-regulation of telomeric recombination at telomere" EXACT [GOC:mah]
synonym: "upregulation of telomeric recombination at telomere" EXACT [GOC:mah]
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0072695 ! regulation of DNA recombination at telomere

[Term]
id: GO:0072697
name: protein localization to cell cortex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah]
synonym: "protein localisation to cell cortex" EXACT [GOC:mah]
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0072698
name: protein localization to microtubule cytoskeleton
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah]
synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah]
is_a: GO:0044380 ! protein localization to cytoskeleton

[Term]
id: GO:0072699
name: protein localization to cortical microtubule cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton." [GOC:mah]
synonym: "protein localisation to cortical microtubule cytoskeleton" EXACT [GOC:mah]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton

[Term]
id: GO:0072700
name: response to bismuth
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [GOC:mah]
synonym: "response to bismuth ion" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0072701
name: cellular response to bismuth
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [GOC:mah]
synonym: "cellular response to bismuth ion" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0072700 ! response to bismuth

[Term]
id: GO:0072702
name: response to methyl methanesulfonate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [GOC:mah]
synonym: "response to MMS" EXACT [CHEBI:25255, GOC:mah]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0072703
name: cellular response to methyl methanesulfonate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [GOC:mah]
synonym: "cellular response to MMS" EXACT [CHEBI:25255, GOC:mah]
is_a: GO:0072702 ! response to methyl methanesulfonate
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072704
name: response to mercaptoethanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [GOC:mah]
synonym: "response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah]
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0072705
name: cellular response to mercaptoethanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [GOC:mah]
synonym: "cellular response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah]
is_a: GO:0072704 ! response to mercaptoethanol
is_a: GO:0097306 ! cellular response to alcohol

[Term]
id: GO:0072706
name: response to sodium dodecyl sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [GOC:mah]
synonym: "response to SDS" EXACT [CHEBI:8984, GOC:mah]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0072707
name: cellular response to sodium dodecyl sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [GOC:mah]
synonym: "cellular response to SDS" EXACT [CHEBI:8984, GOC:mah]
is_a: GO:0072706 ! response to sodium dodecyl sulfate
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072708
name: response to sorbitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [GOC:mah]
synonym: "response to glucitol" EXACT [CHEBI:30911, GOC:mah]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0072709
name: cellular response to sorbitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [GOC:mah]
synonym: "cellular response to glucitol" EXACT [CHEBI:30911, GOC:mah]
is_a: GO:0071322 ! cellular response to carbohydrate stimulus
is_a: GO:0072708 ! response to sorbitol

[Term]
id: GO:0072710
name: response to hydroxyurea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah]
synonym: "response to HU" EXACT [GOC:mah]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0072711
name: cellular response to hydroxyurea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah]
synonym: "cellular response to HU" EXACT [GOC:mah]
is_a: GO:0072710 ! response to hydroxyurea
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0072712
name: response to thiabendazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [GOC:mah]
synonym: "response to TBZ" EXACT [CHEBI:45979, GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0072713
name: cellular response to thiabendazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [GOC:mah]
synonym: "cellular response to TBZ" EXACT [CHEBI:45979, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072712 ! response to thiabendazole
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0072714
name: response to selenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [GOC:mah]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0072715
name: cellular response to selenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [GOC:mah]
is_a: GO:0072714 ! response to selenite ion
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072716
name: response to actinomycin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [GOC:mah]
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0072717
name: cellular response to actinomycin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [GOC:mah]
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0072716 ! response to actinomycin D
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072718
name: response to cisplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0072719
name: cellular response to cisplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0072718 ! response to cisplatin

[Term]
id: GO:0072720
name: response to dithiothreitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [GOC:mah]
synonym: "response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah]
synonym: "response to DTT" EXACT [GOC:mah]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0072721
name: cellular response to dithiothreitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [GOC:mah]
synonym: "cellular response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah]
synonym: "cellular response to DTT" EXACT [GOC:mah]
is_a: GO:0072720 ! response to dithiothreitol
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072722
name: response to amitrole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [GOC:mah]
synonym: "response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0072723
name: cellular response to amitrole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [GOC:mah]
synonym: "cellular response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072722 ! response to amitrole
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0072724
name: response to 4-nitroquinoline N-oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0072725
name: cellular response to 4-nitroquinoline N-oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072724 ! response to 4-nitroquinoline N-oxide
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072726
name: obsolete response to CCCP
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [GOC:mah]
comment: This term is out of scope for GO.
synonym: "response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah]
is_obsolete: true

[Term]
id: GO:0072727
name: obsolete cellular response to CCCP
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [GOC:mah]
comment: This term is out of scope for GO.
synonym: "cellular response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah]
is_obsolete: true

[Term]
id: GO:0072728
name: response to Gentian violet
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [GOC:mah]
synonym: "response to crystal violet" EXACT [GOC:mah]
synonym: "response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0072729
name: cellular response to Gentian violet
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [GOC:mah]
synonym: "cellular response to crystal violet" EXACT [GOC:mah]
synonym: "cellular response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0072728 ! response to Gentian violet

[Term]
id: GO:0072730
name: response to papulacandin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0072731
name: cellular response to papulacandin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072730 ! response to papulacandin B
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072732
name: cellular response to calcium ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions." [GOC:mah]
synonym: "cellular response to calcium starvation" EXACT [GOC:mah]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0072733
name: response to staurosporine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0072734
name: cellular response to staurosporine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [GOC:mah]
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072733 ! response to staurosporine

[Term]
id: GO:0072735
name: response to tert-butyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah]
synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090]
synonym: "response to t-BOOH" EXACT [GOC:mah]
is_a: GO:0033195 ! response to alkyl hydroperoxide

[Term]
id: GO:0072736
name: cellular response to tert-butyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah]
synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090]
synonym: "cellular response to t-BOOH" EXACT [GOC:mah]
is_a: GO:0071448 ! cellular response to alkyl hydroperoxide
is_a: GO:0072735 ! response to tert-butyl hydroperoxide

[Term]
id: GO:0072737
name: response to diamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [GOC:mah]
synonym: "response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0072738
name: cellular response to diamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [GOC:mah]
synonym: "cellular response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958]
is_a: GO:0072737 ! response to diamide
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0072739
name: response to anisomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [GOC:mah]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0072740
name: cellular response to anisomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [GOC:mah]
is_a: GO:0072739 ! response to anisomycin

[Term]
id: GO:0072741
name: protein localization to cell division site
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division." [GOC:mah, PMID:19756689]
synonym: "protein localisation to cell division site" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0072742
name: SAGA complex localization to transcription regulatory region
namespace: biological_process
def: "Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene." [GOC:mah]
synonym: "SAGA complex localization to promoter" EXACT [GOC:mah]
synonym: "SAGA complex recruitment" EXACT [GOC:mah]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0072743
name: cellular response to erythromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901323 ! response to erythromycin
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072744
name: cellular response to trichodermin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:mah]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901324 ! response to trichodermin

[Term]
id: GO:0072745
name: cellular response to antimycin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901325 ! response to antimycin A
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072746
name: cellular response to tetracycline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:mah]
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901326 ! response to tetracycline
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0072747
name: cellular response to chloramphenicol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:mah]
is_a: GO:1901322 ! response to chloramphenicol
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072748
name: cellular response to tacrolimus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus (FK506) stimulus." [GOC:mah]
synonym: "cellular response to FK506" EXACT [CHEBI:61057]
synonym: "cellular response to tacrolimus hydrate" EXACT [CHEBI:61057]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901327 ! response to tacrolimus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072749
name: cellular response to cytochalasin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901328 ! response to cytochalasin B
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072750
name: cellular response to leptomycin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901344 ! response to leptomycin B

[Term]
id: GO:0072751
name: cellular response to L-thialysine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:mah]
synonym: "cellular response to thialysine" BROAD [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901345 ! response to L-thialysine
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072752
name: cellular response to rapamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901355 ! response to rapamycin
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0072753
name: cellular response to glutathione
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:mah]
is_a: GO:1901370 ! response to glutathione
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072754
name: cellular response to purvalanol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:mah]
is_a: GO:0071415 ! cellular response to purine-containing compound
is_a: GO:1901560 ! response to purvalanol A

[Term]
id: GO:0072755
name: obsolete cellular response to benomyl
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:mah]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:0072756
name: cellular response to paraquat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:mah]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901562 ! response to paraquat

[Term]
id: GO:0072757
name: cellular response to camptothecin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:mah]
synonym: "cellular response to CPT" EXACT [GOC:mah]
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901563 ! response to camptothecin

[Term]
id: GO:0072758
name: response to topoisomerase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0072759
name: cellular response to topoisomerase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0072758 ! response to topoisomerase inhibitor

[Term]
id: GO:0072760
name: cellular response to GW 7647
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:mah]
is_a: GO:1901593 ! response to GW 7647

[Term]
id: GO:0072761
name: cellular response to capsazepine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901594 ! response to capsazepine
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072762
name: cellular response to carbendazim
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901597 ! response to carbendazim
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072763
name: cellular response to hesperadin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071418 ! cellular response to amine stimulus
is_a: GO:1901595 ! response to hesperadin
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072764
name: cellular response to reversine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:mah]
is_a: GO:0071415 ! cellular response to purine-containing compound
is_a: GO:1901596 ! response to reversine
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0072765
name: centromere localization
namespace: biological_process
def: "A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of kinetochore localization" EXACT [GOC:mah]
synonym: "kinetochore localisation" EXACT [GOC:mah]
synonym: "kinetochore localization" EXACT []
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0072766
name: centromere clustering at the mitotic interphase nuclear envelope
namespace: biological_process
def: "The process in which chromatin, or kinetochores are anchored to the nuclear envelope. This process involves the microtubule cytoskeleton, and nuclear tethering factors and is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei." [GOC:mah, GOC:vw, PMID:21965289, PMID:23166349]
synonym: "centromere clustering at the mitotic nuclear envelope" RELATED []
synonym: "centromere clustering at the nuclear periphery" BROAD []
synonym: "centromere-SPB clustering" BROAD [GOC:vw, PMID:18158900]
synonym: "kinetochore clustering at SPB" BROAD [GOC:mah]
synonym: "kinetochore clustering at spindle pole body" BROAD []
synonym: "kinetochore clustering at the old mitotic spindle pole body" EXACT []
synonym: "kinetochore localization at spindle pole body" BROAD [GOC:pr]
synonym: "rabl configuration" RELATED [PMID:17881496]
is_a: GO:0097240 ! chromosome attachment to the nuclear envelope
is_a: GO:0098653 ! centromere clustering
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:0075000
name: response to host osmotic environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response of symbiont to host osmotic environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075001
name: adhesion of symbiont infection structure to host
namespace: biological_process
def: "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process.
synonym: "adhesion of symbiont infection structure to host during symbiotic interaction" EXACT []
synonym: "attachment of symbiont infection structure to host" EXACT []
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0075002
name: adhesion of symbiont germination tube to host
namespace: biological_process
def: "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont germination tube to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075003
name: adhesion of symbiont appressorium to host
namespace: biological_process
def: "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont appressorium to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host
relationship: part_of GO:0075016 ! appressorium formation

[Term]
id: GO:0075004
name: adhesion of symbiont spore to host
namespace: biological_process
def: "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont spore to host during symbiotic interaction" EXACT []
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0075009
name: germ tube formation
namespace: biological_process
def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "germ tube formation on or near host" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009847 ! spore germination

[Term]
id: GO:0075010
name: regulation of germ tube formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0075009 ! germ tube formation

[Term]
id: GO:0075011
name: positive regulation of germ tube formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "positive regulation of germ tube formation on or near host" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075010 ! regulation of germ tube formation
relationship: positively_regulates GO:0075009 ! germ tube formation

[Term]
id: GO:0075012
name: negative regulation of germ tube formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "negative regulation of germ tube formation on or near host" EXACT []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0075010 ! regulation of germ tube formation
relationship: negatively_regulates GO:0075009 ! germ tube formation

[Term]
id: GO:0075013
name: obsolete growth or development of symbiont on or near host phyllosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "growth or development of symbiont on or near host phyllosphere" EXACT []
is_obsolete: true

[Term]
id: GO:0075014
name: obsolete growth or development of symbiont on or near host rhizosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "growth or development of symbiont on or near host rhizosphere" EXACT []
is_obsolete: true

[Term]
id: GO:0075015
name: formation of infection structure
namespace: biological_process
def: "The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process.
synonym: "formation by symbiont of infection structure on or near host" RELATED []
synonym: "formation of host infection structure" EXACT []
synonym: "formation of host penetration structure" RELATED []
synonym: "formation of infection structure on or near host" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0044409 ! symbiont entry into host

[Term]
id: GO:0075016
name: appressorium formation
namespace: biological_process
def: "The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface." [GOC:pamgo_curators]
synonym: "appressorium formation for entry into host, on or near host" EXACT []
synonym: "appressorium formation on or near host" RELATED []
synonym: "formation of an appressorium by symbiont on or near host" EXACT []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075017
name: regulation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont appressorium formation." [GOC:pamgo_curators]
synonym: "regulation of appressorium formation on or near host" RELATED []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0075016 ! appressorium formation

[Term]
id: GO:0075018
name: positive regulation of appressorium formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of appressorium formation on or near host" RELATED []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075017 ! regulation of appressorium formation
relationship: positively_regulates GO:0075016 ! appressorium formation

[Term]
id: GO:0075019
name: negative regulation of appressorium formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of appressorium formation on or near host" RELATED []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0075017 ! regulation of appressorium formation
relationship: negatively_regulates GO:0075016 ! appressorium formation

[Term]
id: GO:0075020
name: obsolete calcium or calmodulin-mediated activation of appressorium formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Ca++ or calmodulin-mediated activation of appressorium formation" EXACT []
synonym: "Ca2+ or calmodulin-mediated activation of appressorium formation" EXACT []
is_obsolete: true

[Term]
id: GO:0075021
name: obsolete cAMP-mediated activation of appressorium formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "cyclic AMP mediated activation of appressorium formation" EXACT []
is_obsolete: true

[Term]
id: GO:0075022
name: obsolete ethylene-mediated activation of appressorium formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0075023
name: obsolete MAPK-mediated regulation of appressorium formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "mitogen-activated protein kinase-mediated activation of appressorium formation" EXACT []
is_obsolete: true

[Term]
id: GO:0075024
name: obsolete phospholipase C-mediated activation of appressorium formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0075025
name: initiation of appressorium formation
namespace: biological_process
def: "The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "appressorium initiation on or near host" EXACT []
synonym: "initiation of appressorium by symbiont on or near host" EXACT []
synonym: "initiation of appressorium on or near host" RELATED []
synonym: "initiation of symbiont appressorium on or near host" EXACT []
is_a: GO:0044111 ! formation of structure involved in a symbiotic process
relationship: part_of GO:0075016 ! appressorium formation

[Term]
id: GO:0075026
name: obsolete regulation of appressorium initiation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont appressorium initiation." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "regulation of appressorium initiation on or near host" RELATED []
synonym: "regulation of initiation of appressorium on or near host" EXACT []
is_obsolete: true
consider: GO:0075017

[Term]
id: GO:0075027
name: obsolete positive regulation of appressorium initiation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "positive regulation of appressorium initiation on or near host" RELATED []
synonym: "positive regulation of initiation of appressorium on or near host" EXACT []
is_obsolete: true
consider: GO:0075018

[Term]
id: GO:0075028
name: obsolete negative regulation of appressorium initiation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium initiation." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "negative regulation of appressorium initiation on or near host" RELATED []
synonym: "negative regulation of initiation of appressorium on or near host" EXACT []
is_obsolete: true
consider: GO:0075019

[Term]
id: GO:0075029
name: formation of appressorium germ tube hook structure
namespace: biological_process
def: "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation." [GOC:pamgo_curators]
synonym: "formation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "formation of symbiont germ tube hook structure for appressorium development" EXACT []
synonym: "formation of symbiont germ tube hook structure on or near host" RELATED []
synonym: "symbiont germ tube hook structure formation on or near host" EXACT []
is_a: GO:0075015 ! formation of infection structure
relationship: part_of GO:0075025 ! initiation of appressorium formation

[Term]
id: GO:0075030
name: modulation of formation of symbiont germ tube hook structure for appressorium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation." [GOC:pamgo_curators]
synonym: "modulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "modulation of symbiont germ tube hook structure formation on or near host" RELATED []
synonym: "regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0075029 ! formation of appressorium germ tube hook structure

[Term]
id: GO:0075031
name: positive regulation of formation of symbiont germ tube hook structure for appressorium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation." [GOC:pamgo_curators]
synonym: "positive regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
synonym: "positive regulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "positive regulation of symbiont germ tube hook structure formation on or near host" RELATED []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075030 ! modulation of formation of symbiont germ tube hook structure for appressorium development
relationship: positively_regulates GO:0075029 ! formation of appressorium germ tube hook structure

[Term]
id: GO:0075032
name: negative regulation of formation of symbiont germ tube hook structure for appressorium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation." [GOC:pamgo_curators]
synonym: "negative regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
synonym: "negative regulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "negative regulation of symbiont germ tube hook structure formation on or near host" RELATED []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0075030 ! modulation of formation of symbiont germ tube hook structure for appressorium development
relationship: negatively_regulates GO:0075029 ! formation of appressorium germ tube hook structure

[Term]
id: GO:0075033
name: obsolete appressorium septum formation
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont partition is formed to separate the appressorium from the germination tube, occurring during appressorium formation." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "septum formation during appressorium formation on or near host" RELATED [GOC:tb]
synonym: "septum formation involved in appressorium formation" EXACT []
synonym: "septum formation involved in appressorium formation on or near host" EXACT []
is_obsolete: true

[Term]
id: GO:0075034
name: obsolete nuclear division involved in appressorium formation
namespace: biological_process
def: "OBSOLETE. The process in which nuclear division occurs within a symbiont spore that contributes to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "nuclear division during appressorium formation on or near host" RELATED [GOC:dph]
synonym: "nuclear division involved in appressorium formation on or near host" RELATED []
is_obsolete: true

[Term]
id: GO:0075035
name: appressorium maturation
namespace: biological_process
def: "The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "appressorium maturation on or near host" EXACT []
synonym: "maturation of appressorium on or near host" RELATED []
synonym: "maturation of symbiont appressorium on or near host" EXACT []
is_a: GO:0044111 ! formation of structure involved in a symbiotic process
relationship: part_of GO:0075016 ! appressorium formation

[Term]
id: GO:0075036
name: obsolete regulation of appressorium maturation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont appressorium maturation." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "regulation of appressorium maturation on or near host" RELATED []
synonym: "regulation of maturation of appressorium on or near host" EXACT []
is_obsolete: true
consider: GO:0075017

[Term]
id: GO:0075037
name: obsolete positive regulation of appressorium maturation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "positive regulation maturation of appressorium on or near host" EXACT []
synonym: "positive regulation of appressorium maturation on or near host" RELATED []
is_obsolete: true
consider: GO:0075018

[Term]
id: GO:0075038
name: obsolete negative regulation of appressorium maturation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium maturation." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "negative regulation of appressorium maturation on or near host" RELATED []
synonym: "negative regulation of maturation of appressorium on or near host" EXACT []
is_obsolete: true
consider: GO:0075019

[Term]
id: GO:0075039
name: establishment of turgor in appressorium
namespace: biological_process
def: "The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "establishment of turgor in symbiont appressorium on or near host" EXACT []
synonym: "formation of turgor in appressorium" EXACT []
synonym: "generation of turgor in appressorium" EXACT []
is_a: GO:0044111 ! formation of structure involved in a symbiotic process
relationship: part_of GO:0075035 ! appressorium maturation

[Term]
id: GO:0075040
name: obsolete regulation of establishment of turgor in appressorium
namespace: biological_process
def: "OBSOLETE. Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
synonym: "regulation of turgor formation in appressorium" RELATED []
is_obsolete: true
consider: GO:0075017

[Term]
id: GO:0075041
name: obsolete positive regulation of establishment of turgor in appressorium
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true
consider: GO:0075018

[Term]
id: GO:0075042
name: obsolete negative regulation of establishment of turgor in appressorium
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true
consider: GO:0075019

[Term]
id: GO:0075043
name: melanization of appressorium wall
namespace: biological_process
def: "The process in which melanin is produced in the appressorium of the symbiont. Melanization of the appressorium increases turgor pressure in the appressorium." [GOC:pamgo_curators, PMID:28165657, Wikipedia:Appressorium]
synonym: "maintenance of turgor in appressorium by melanization" RELATED []
synonym: "melanization of appressorium to maintain turgor pressure" EXACT []
is_a: GO:0043476 ! pigment accumulation
relationship: part_of GO:0075035 ! appressorium maturation

[Term]
id: GO:0075045
name: regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
relationship: regulates GO:0052094 ! formation of haustorium for nutrient acquisition

[Term]
id: GO:0075046
name: positive regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process
is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host
relationship: positively_regulates GO:0052094 ! formation of haustorium for nutrient acquisition

[Term]
id: GO:0075047
name: negative regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process
is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host
relationship: negatively_regulates GO:0052094 ! formation of haustorium for nutrient acquisition

[Term]
id: GO:0075048
name: obsolete cell wall strengthening in symbiont involved in entry into host
namespace: biological_process
def: "OBSOLETE. A process in which the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "cell wall strengthening in symbiont during entry into host" RELATED [GOC:tb]
synonym: "cell wall thickening in symbiont during entry into host" RELATED []
synonym: "symbiont cell wall strengthening during entry into host" RELATED []
is_obsolete: true

[Term]
id: GO:0075049
name: obsolete modulation of symbiont cell wall strengthening involved in entry into host
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for the obsoletion is that there is no evidence that those processes exist.
synonym: "modulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0075050
name: obsolete positive regulation of symbiont cell wall strengthening involved in entry into host
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for the obsoletion is that there is no evidence that those processes exist.
synonym: "positive regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0075051
name: obsolete negative regulation of symbiont cell wall strengthening involved in entry into host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for the obsoletion is that there is no evidence that those processes exist.
synonym: "negative regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0075053
name: penetration peg formation
namespace: biological_process
alt_id: GO:0075057
def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:26441323]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of symbiont penetration peg for entry into host" RELATED []
synonym: "initiation of symbiont penetration peg" NARROW []
synonym: "symbiont penetration peg formation for entry into host" RELATED []
synonym: "symbiont penetration peg initiation" NARROW []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075054
name: modulation of penetration peg formation
namespace: biological_process
alt_id: GO:0075058
def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "modulation of symbiont penetration peg formation for entry into host" NARROW []
synonym: "modulation of symbiont penetration peg initiation" NARROW []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075053 ! penetration peg formation

[Term]
id: GO:0075055
name: positive regulation of penetration peg formation
namespace: biological_process
alt_id: GO:0075059
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of symbiont penetration peg formation for entry into host" NARROW []
synonym: "positive regulation of symbiont penetration peg initiation" NARROW []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075054 ! modulation of penetration peg formation
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
relationship: positively_regulates GO:0075053 ! penetration peg formation

[Term]
id: GO:0075056
name: obsolete negative regulation of penetration peg formation
namespace: biological_process
alt_id: GO:0075060
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont penetration peg formation for entry into host" NARROW []
synonym: "negative regulation of symbiont penetration peg initiation" NARROW []
is_obsolete: true

[Term]
id: GO:0075062
name: obsolete regulation of invasive hypha growth
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont invasive hypha formation in host" EXACT []
synonym: "regulation of symbiont invasive hypha formation within host" EXACT []
is_obsolete: true

[Term]
id: GO:0075063
name: obsolete positive regulation of invasive hypha growth
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont invasive hypha formation in host" EXACT []
synonym: "positive regulation of symbiont invasive hypha formation within host" EXACT []
is_obsolete: true

[Term]
id: GO:0075064
name: obsolete negative regulation invasive hypha growth
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont invasive hypha formation in host" EXACT []
synonym: "negative regulation of symbiont invasive hypha formation within host" EXACT []
is_obsolete: true

[Term]
id: GO:0075065
name: obsolete growth or development of symbiont in host cell
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development of symbiont in host cell" EXACT []
is_obsolete: true

[Term]
id: GO:0075066
name: obsolete growth or development of symbiont in host organelle
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development of symbiont in host organelle" EXACT []
is_obsolete: true

[Term]
id: GO:0075067
name: obsolete growth or development of symbiont in host intercellular space
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "growth or development of symbiont in host intercellular space" EXACT []
is_obsolete: true
consider: GO:0044114
consider: GO:0051701

[Term]
id: GO:0075068
name: obsolete growth or development of symbiont in host vascular tissue
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host vascular tissue ; GO:0044122' and 'growth of symbiont in host vascular tissue ; GO:0044123'.
synonym: "growth or development of symbiont in host vascular tissue" EXACT []
is_obsolete: true
consider: GO:0044114
consider: GO:0051701

[Term]
id: GO:0075069
name: adhesion of symbiont infection cushion to host
namespace: biological_process
def: "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont infection cushion to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075070
name: adhesion of symbiont hyphopodium to host
namespace: biological_process
def: "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont hyphopodium to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075071
name: symbiont-mediated perturbation of host autophagy
namespace: biological_process
def: "A process in which a symbiont alters or subverts autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "autophagy during symbiotic interaction" RELATED [GOC:dph]
synonym: "autophagy involved in symbiotic interaction" RELATED []
synonym: "modulation by symbiont of host autophagic process" RELATED []
synonym: "modulation by symbiont of host autophagy" EXACT []
synonym: "symbiont-mediated modulation of host autophagy" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0075072
name: obsolete autophagy of symbiont cells involved in interaction with host
namespace: biological_process
def: "OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process.
synonym: "autophagy of symbiont cells during interaction with host" RELATED [GOC:dph]
is_obsolete: true

[Term]
id: GO:0075073
name: obsolete autophagy of symbiont cells on or near host surface
namespace: biological_process
def: "OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process.
is_obsolete: true

[Term]
id: GO:0075074
name: obsolete spore autophagy involved in appressorium formation on or near host
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process.
synonym: "autophagy of spores during appressorium formation on or near host" EXACT []
synonym: "spore autophagy during appressorium formation on or near host" RELATED [GOC:tb]
is_obsolete: true

[Term]
id: GO:0075075
name: obsolete modulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0075076
name: obsolete positive regulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0075077
name: obsolete negative regulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0075078
name: obsolete modulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075079
name: obsolete positive regulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075080
name: obsolete negative regulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075081
name: obsolete modulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075082
name: obsolete positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075083
name: obsolete negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075084
name: obsolete modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "modulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075085
name: obsolete positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
synonym: "promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction" EXACT []
synonym: "stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075086
name: obsolete negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075087
name: obsolete modulation by host of symbiont G protein-coupled receptor signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "modulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075088
name: obsolete positive regulation by host of symbiont G protein-coupled receptor signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "positive regulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075089
name: obsolete negative regulation by host of symbiont G protein-coupled receptor signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "negative regulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075090
name: obsolete modulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075091
name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075092
name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075093
name: obsolete modulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075094
name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075095
name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075096
name: obsolete modulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075097
name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075098
name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075099
name: obsolete modulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075100
name: obsolete positive regulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075101
name: obsolete negative regulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075102
name: obsolete negative regulation by host of symbiont MAP kinase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075103
name: obsolete modulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075104
name: obsolete positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075105
name: obsolete negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075106
name: obsolete modulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Modulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Modulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Modulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Modulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Modulation by symbiont of host cAMP generating peptide activity" RELATED []
is_obsolete: true

[Term]
id: GO:0075107
name: obsolete positive regulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "positive regulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "positive regulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "positive regulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
is_obsolete: true

[Term]
id: GO:0075108
name: obsolete negative regulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Negative regulation by symbiont of host cAMP generating peptide activity" RELATED []
is_obsolete: true

[Term]
id: GO:0075109
name: symbiont-mediated perturbation of host receptor-mediated signal transduction
namespace: biological_process
def: "A process by which a symbiont alters or subverts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "perturbation of host receptor-mediated signal transduction" EXACT []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0075110
name: obsolete induction by symbiont of host receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "positive regulation by symbiont of host receptor-mediated signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075111
name: symbiont-mediated suppression of host receptor-mediated signal transduction
namespace: biological_process
def: "A process in which a virus interferes with, inhibits or disrupts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080".
synonym: "disruption of host receptor-mediated signal transduction" EXACT []
synonym: "negative regulation by symbiont of host receptor-mediated signal transduction" EXACT []
synonym: "suppression by symbiont of host receptor-mediated signal transduction" EXACT []
is_a: GO:0075109 ! symbiont-mediated perturbation of host receptor-mediated signal transduction

[Term]
id: GO:0075112
name: obsolete symbiont-mediated perturbation of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont alters a transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "modulation by symbiont of host transmembrane receptor-mediated signal transduction" EXACT []
synonym: "perturbation of host transmembrane receptor-mediated signal transduction" EXACT []
is_obsolete: true
replaced_by: GO:0075109

[Term]
id: GO:0075113
name: obsolete induction by symbiont of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "positive regulation by symbiont of host transmembrane receptor-mediated signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075114
name: obsolete symbiont-mediated suppression of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "disruption of host transmembrane receptor-mediated signal transduction" EXACT []
synonym: "negative regulation by symbiont of host transmembrane receptor-mediated signal transduction" EXACT []
synonym: "suppression by symbiont of host transmembrane receptor-mediated signal transduction" EXACT []
is_obsolete: true
replaced_by: GO:0052029

[Term]
id: GO:0075115
name: obsolete modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "modulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075116
name: obsolete induction by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
synonym: "promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075117
name: obsolete suppression by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075118
name: symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway
namespace: biological_process
alt_id: GO:0075121
alt_id: GO:0075124
alt_id: GO:0075127
def: "A process by which a symbiont alters or subverts the normal execution of a host G protein-coupled receptor signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modulation by symbiont of host G protein-coupled receptor signal transduction" EXACT []
synonym: "modulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT []
synonym: "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW []
synonym: "modulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW []
synonym: "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW []
synonym: "perturbation of host G protein-coupled receptor signal transduction pathway" EXACT []
is_a: GO:0075109 ! symbiont-mediated perturbation of host receptor-mediated signal transduction

[Term]
id: GO:0075119
name: obsolete induction by symbiont of host G protein-coupled receptor signal transduction
namespace: biological_process
alt_id: GO:0075122
alt_id: GO:0075125
alt_id: GO:0075128
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "positive regulation by symbiont of host G protein-coupled receptor signal transduction" EXACT []
synonym: "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT []
synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW []
synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW []
synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW []
is_obsolete: true

[Term]
id: GO:0075120
name: symbiont-mediated suppression of host G protein-coupled receptor signal transduction
namespace: biological_process
alt_id: GO:0075123
alt_id: GO:0075126
alt_id: GO:0075129
def: "A process in which a symbiont interferes with, inhibits or disrupts a G protein-coupled receptor signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:17562776, PMID:23027529]
synonym: "disruption of host G protein-coupled receptor signal transduction" EXACT []
synonym: "negative regulation by symbiont of host G protein-coupled receptor signal transduction" EXACT []
synonym: "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT []
synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW []
synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW []
synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW []
synonym: "suppression by symbiont of host G protein-coupled receptor signal transduction" EXACT []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway
is_a: GO:0075118 ! symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway

[Term]
id: GO:0075130
name: obsolete perturbation of host protein kinase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it does not represent a specific signaling pathway, and is not a grouping term either.
synonym: "modulation by symbiont of host protein kinase-mediated signal transduction" EXACT []
is_obsolete: true
replaced_by: GO:0052027

[Term]
id: GO:0075131
name: obsolete induction by symbiont of host protein kinase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
is_obsolete: true

[Term]
id: GO:0075132
name: obsolete disruption of host protein kinase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which a symbiont interferes with protein kinase-mediated signal transduction in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it does not represent a specific signaling pathway, and is not a grouping term either.
synonym: "negative regulation by symbiont of host protein kinase-mediated signal transduction" EXACT []
synonym: "suppression by symbiont of host protein kinase-mediated signal transduction" EXACT []
is_obsolete: true
replaced_by: GO:0052029

[Term]
id: GO:0075133
name: obsolete symbiont-mediated perturbation of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont alters or subverts a calcium or calmodulin-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is an unnecessary grouping term.
synonym: "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
synonym: "perturbation of host calcium or calmodulin-mediated signal transduction" EXACT []
is_obsolete: true
replaced_by: GO:0075135

[Term]
id: GO:0075134
name: obsolete induction by symbiont of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
synonym: "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction" EXACT []
is_obsolete: true

[Term]
id: GO:0075135
name: symbiont-mediated suppression of host calcium-mediated signal transduction
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a calcium signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "disruption of host calcium or calmodulin-mediated signal transduction" EXACT []
synonym: "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" RELATED []
synonym: "negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction" RELATED []
synonym: "suppression by symbiont of host calcium or calmodulin-mediated signal transduction" RELATED []
synonym: "symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction" RELATED []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0075136
name: response to host
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host" RELATED []
is_a: GO:0051701 ! biological process involved in interaction with host
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0075137
name: response to host redox environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host redox environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075138
name: response to host oxygen tension environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host oxygen tension environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075139
name: response to host iron concentration
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host iron concentration" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075141
name: obsolete symbiont tolerance to host environment
namespace: biological_process
alt_id: GO:0075142
alt_id: GO:0075143
alt_id: GO:0075144
alt_id: GO:0075146
alt_id: GO:0075238
def: "OBSOLETE. Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is redundant with other terms.
synonym: "maintenance of symbiont tolerance to host environment" RELATED []
synonym: "maintenance of symbiont tolerance to host iron concentration" NARROW []
synonym: "maintenance of symbiont tolerance to host osmotic environment" NARROW []
synonym: "maintenance of symbiont tolerance to host oxygen tension environment" NARROW []
synonym: "maintenance of symbiont tolerance to host pH environment" NARROW []
synonym: "maintenance of symbiont tolerance to host redox environment" NARROW []
is_obsolete: true
consider: GO:0052200

[Term]
id: GO:0075147
name: obsolete regulation of signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075148
name: obsolete positive regulation of signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075149
name: obsolete negative regulation of signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075150
name: obsolete regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075151
name: obsolete positive regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075152
name: obsolete negative regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075153
name: obsolete regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075154
name: obsolete positive regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075155
name: obsolete negative regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075156
name: obsolete regulation of G protein-coupled receptor signaling pathway in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT []
synonym: "regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah]
synonym: "regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075157
name: obsolete positive regulation of G protein-coupled receptor signaling pathway in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT []
synonym: "positive regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah]
synonym: "positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075158
name: obsolete negative regulation of G protein-coupled receptor signaling pathway in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT []
synonym: "negative regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah]
synonym: "negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075159
name: obsolete regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075160
name: obsolete positive regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075161
name: obsolete negative regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075162
name: obsolete regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075163
name: obsolete positive regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075164
name: obsolete negative regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075165
name: obsolete regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075166
name: obsolete positive regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075167
name: obsolete negative regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075168
name: obsolete regulation of protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075169
name: obsolete positive regulation of symbiont protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075170
name: obsolete negative regulation of protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075171
name: obsolete regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075172
name: obsolete positive regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075173
name: obsolete negative regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075174
name: obsolete regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075175
name: obsolete positive regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "positive regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "positive regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075176
name: obsolete negative regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "negative regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "negative regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075177
name: obsolete regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075178
name: obsolete positive regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075179
name: obsolete negative regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075180
name: obsolete regulation of transcription in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006355

[Term]
id: GO:0075181
name: obsolete positive regulation of symbiont transcription in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006355

[Term]
id: GO:0075182
name: obsolete negative regulation of symbiont transcription in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0045892

[Term]
id: GO:0075183
name: infection cushion formation
namespace: biological_process
def: "The process in which an organized mass of hyphae is formed and numerous infective hyphae develop from the hyphae mass." [GOC:pamgo_curators]
synonym: "infection cushion formation on or near host" EXACT []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075184
name: regulation of infection cushion formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation." [GOC:pamgo_curators]
synonym: "regulation of infection cushion formation on or near host" EXACT []
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0075183 ! infection cushion formation

[Term]
id: GO:0075185
name: positive regulation of infection cushion formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "positive regulation of infection cushion formation on or near host" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075184 ! regulation of infection cushion formation
relationship: positively_regulates GO:0075183 ! infection cushion formation

[Term]
id: GO:0075186
name: negative regulation of infection cushion formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "negative regulation of infection cushion formation on or near host" EXACT []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0075184 ! regulation of infection cushion formation
relationship: negatively_regulates GO:0075183 ! infection cushion formation

[Term]
id: GO:0075187
name: hyphopodium formation
namespace: biological_process
def: "The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "hyphopodium formation on or near host" EXACT []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075188
name: regulation of hyphopodium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of hyphopodium formation on or near host" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0075187 ! hyphopodium formation

[Term]
id: GO:0075189
name: positive regulation of hyphopodium formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "positive regulation of hyphopodium formation on or near host" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075188 ! regulation of hyphopodium formation
relationship: positively_regulates GO:0075187 ! hyphopodium formation

[Term]
id: GO:0075190
name: negative regulation of hyphopodium formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "negative regulation of hyphopodium formation on or near host" EXACT []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0075188 ! regulation of hyphopodium formation
relationship: negatively_regulates GO:0075187 ! hyphopodium formation

[Term]
id: GO:0075191
name: obsolete autophagy of host cells on or near symbiont surface
namespace: biological_process
def: "OBSOLETE. The process in which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process.
is_obsolete: true

[Term]
id: GO:0075192
name: haustorium mother cell formation
namespace: biological_process
def: "The process in which a symbiont cell is formed, separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "haustorium mother cell formation on or near host" EXACT []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075193
name: regulation of haustorium mother cell formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of haustorium mother cell formation on or near host" EXACT []
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0075192 ! haustorium mother cell formation

[Term]
id: GO:0075194
name: positive regulation of haustorium mother cell formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of haustorium mother cell formation on or near host" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075193 ! regulation of haustorium mother cell formation
relationship: positively_regulates GO:0075192 ! haustorium mother cell formation

[Term]
id: GO:0075195
name: negative regulation of haustorium mother cell formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of haustorium mother cell formation on or near host" EXACT []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0075193 ! regulation of haustorium mother cell formation
relationship: negatively_regulates GO:0075192 ! haustorium mother cell formation

[Term]
id: GO:0075196
name: adhesion of symbiont haustorium mother cell to host
namespace: biological_process
def: "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont haustorium mother cell to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075197
name: haustorium neck formation
namespace: biological_process
def: "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, Wikipedia:Haustorium]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of symbiont haustorium neck for entry into host" RELATED []
synonym: "symbiont haustorium neck formation for entry into host" RELATED []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075198
name: modulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075197 ! haustorium neck formation

[Term]
id: GO:0075199
name: positive regulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
relationship: positively_regulates GO:0075197 ! haustorium neck formation

[Term]
id: GO:0075200
name: obsolete negative regulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075201
name: penetration hypha formation
namespace: biological_process
def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:26441323]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of symbiont penetration hypha for entry into host" RELATED []
synonym: "symbiont penetration hypha formation for entry into host" RELATED []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075202
name: regulation of penetration hypha formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "modulation of symbiont penetration hypha formation for entry into host" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075201 ! penetration hypha formation

[Term]
id: GO:0075203
name: positive regulation of penetration hypha formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of symbiont penetration hypha formation for entry into host" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0075202 ! regulation of penetration hypha formation
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
relationship: positively_regulates GO:0075201 ! penetration hypha formation

[Term]
id: GO:0075204
name: obsolete negative regulation of symbiont penetration hypha formation for entry into host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075205
name: obsolete modulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "modulation by host of symbiont cAMP-mediated signaling" RELATED []
synonym: "modulation by host of symbiont cAMP-mediated signalling" EXACT []
synonym: "regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075206
name: obsolete positive regulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "positive regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075207
name: obsolete negative regulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
synonym: "negative regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075208
name: obsolete modulation by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term as obsoleted because it is not different from disruption of host cAMP-mediated signal transduction ; GO:0075210.
synonym: "modulation by symbiont of host cAMP-mediated signaling" EXACT []
is_obsolete: true
replaced_by: GO:0075210

[Term]
id: GO:0075209
name: obsolete induction by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because the process it represents it does not exist; this corresponds to a host response to a pathogenic symbiont.
synonym: "positive regulation by symbiont of host cAMP-mediated signal transduction" EXACT []
synonym: "positive regulation by symbiont of host cAMP-mediated signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0075210
name: symbiont-mediated suppression of host cAMP-mediated signal transduction
namespace: biological_process
def: "A process in which a virus interferes with, inhibits or disrupts a cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207".
synonym: "disruption of host cAMP-mediated signal transduction" EXACT []
synonym: "negative regulation by symbiont of host cAMP-mediated signal transduction" NARROW []
synonym: "negative regulation by symbiont of host cAMP-mediated signaling" NARROW []
synonym: "suppression by symbiont of host cAMP-mediated signal transduction" NARROW []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0075211
name: obsolete regulation of transmembrane receptor-mediated cAMP signaling in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
synonym: "regulation of transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
synonym: "regulation of transmembrane receptor-mediated cAMP signalling in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075212
name: obsolete positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" RELATED []
is_obsolete: true

[Term]
id: GO:0075213
name: obsolete negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
is_obsolete: true

[Term]
id: GO:0075214
name: spore encystment
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:kmv, GOC:pamgo_curators]
synonym: "spore encystment on host" RELATED []
is_a: GO:0022611 ! dormancy process
is_a: GO:0048468 ! cell development

[Term]
id: GO:0075215
name: modulation of spore encystment on host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0075214 ! spore encystment

[Term]
id: GO:0075216
name: positive regulation of spore encystment on host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0075215 ! modulation of spore encystment on host
relationship: positively_regulates GO:0075214 ! spore encystment

[Term]
id: GO:0075217
name: negative regulation of spore encystment on host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0075215 ! modulation of spore encystment on host
relationship: negatively_regulates GO:0075214 ! spore encystment

[Term]
id: GO:0075218
name: zoospore encystment on host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075214 ! spore encystment

[Term]
id: GO:0075219
name: modulation of zoospore encystment on host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075215 ! modulation of spore encystment on host
relationship: regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075220
name: positive regulation of zoospore encystment on host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075216 ! positive regulation of spore encystment on host
is_a: GO:0075219 ! modulation of zoospore encystment on host
relationship: positively_regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075221
name: negative regulation of zoospore encystment on host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075217 ! negative regulation of spore encystment on host
is_a: GO:0075219 ! modulation of zoospore encystment on host
relationship: negatively_regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075222
name: sporangium germination
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth. A sporangium is a structure producing and containing spores." [GOC:pamgo_curators]
synonym: "direct germination on or near host" NARROW []
synonym: "germination of symbiont sporangium on or near host" EXACT []
synonym: "sporangium germination on or near host" EXACT []
synonym: "symbiont sporangium germination on or near host" EXACT []
is_a: GO:0043582 ! sporangium development

[Term]
id: GO:0075223
name: regulation of sporangium germination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangium germination." [GOC:pamgo_curators]
synonym: "modulation of sporangium germination" NARROW []
synonym: "modulation of sporangium germination on or near host" NARROW []
is_a: GO:0075310 ! regulation of sporangium development
relationship: regulates GO:0075222 ! sporangium germination

[Term]
id: GO:0075224
name: positive regulation of sporangium germination
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination." [GOC:pamgo_curators]
synonym: "positive regulation of sporangium germination on or near host" NARROW []
is_a: GO:0075223 ! regulation of sporangium germination
is_a: GO:0075311 ! positive regulation of sporangium development
relationship: positively_regulates GO:0075222 ! sporangium germination

[Term]
id: GO:0075225
name: negative regulation of sporangium germination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination." [GOC:pamgo_curators]
synonym: "negative regulation of sporangium germination on or near host" NARROW []
is_a: GO:0075223 ! regulation of sporangium germination
is_a: GO:0075312 ! negative regulation of sporangium development
relationship: negatively_regulates GO:0075222 ! sporangium germination

[Term]
id: GO:0075226
name: encysted zoospore germination
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in an encysted zoospore, that germinates by developing a germ tube that may penetrate the host directly or indirectly through an appressorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "encysted zoospore germination on or near host" EXACT []
is_a: GO:0009847 ! spore germination

[Term]
id: GO:0075227
name: regulation of encysted zoospore germination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an encysted zoospore germination." [GOC:pamgo_curators]
synonym: "modulation of encysted zoospore germination on or near host" EXACT []
synonym: "regulation of encysted zoospore germination on or near host" NARROW []
is_a: GO:1904359 ! regulation of spore germination
relationship: regulates GO:0075226 ! encysted zoospore germination

[Term]
id: GO:0075228
name: positive regulation of encysted zoospore germination
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination." [GOC:pamgo_curators]
synonym: "positive regulation of encysted zoospore germination on or near host" EXACT []
is_a: GO:0075227 ! regulation of encysted zoospore germination
is_a: GO:1904361 ! positive regulation of spore germination
relationship: positively_regulates GO:0075226 ! encysted zoospore germination

[Term]
id: GO:0075229
name: negative regulation of encysted zoospore germination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of encysted zoospore germination." [GOC:pamgo_curators]
synonym: "negative regulation of encysted zoospore germination on or near host" EXACT []
is_a: GO:0075227 ! regulation of encysted zoospore germination
is_a: GO:1904360 ! negative regulation of spore germination
relationship: negatively_regulates GO:0075226 ! encysted zoospore germination

[Term]
id: GO:0075230
name: obsolete spore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0075231
name: obsolete modulation of spore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0075232
name: obsolete positive regulation of spore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0075233
name: obsolete negative regulation of spore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0075234
name: obsolete zoospore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
synonym: "zoospore motility on or near host" EXACT []
is_obsolete: true

[Term]
id: GO:0075235
name: obsolete modulation of zoospore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
synonym: "regulation of zoospore motility on or near host" EXACT []
is_obsolete: true

[Term]
id: GO:0075236
name: obsolete positive regulation of zoospore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0075237
name: obsolete negative regulation of zoospore movement on or near host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represented both a process and a location.
is_obsolete: true

[Term]
id: GO:0075239
name: zoospore formation
namespace: biological_process
def: "The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075240
name: regulation of zoospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075241
name: positive regulation of zoospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075240 ! regulation of zoospore formation
is_a: GO:0075287 ! positive regulation of sporangiospore formation
relationship: positively_regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075242
name: negative regulation of zoospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075240 ! regulation of zoospore formation
is_a: GO:0075288 ! negative regulation of sporangiospore formation
relationship: negatively_regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075243
name: oospore formation
namespace: biological_process
def: "The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of Oomycetes and certain algae and fungi." [GOC:pamgo_curators]
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075244
name: regulation of oospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075245
name: positive regulation of oospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075244 ! regulation of oospore formation
relationship: positively_regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075246
name: negative regulation of oospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075244 ! regulation of oospore formation
relationship: negatively_regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075247
name: aeciospore formation
namespace: biological_process
def: "The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host." [GOC:pamgo_curators]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075248
name: regulation of aeciospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075249
name: positive regulation of aeciospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075248 ! regulation of aeciospore formation
relationship: positively_regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075250
name: negative regulation of aeciospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075248 ! regulation of aeciospore formation
relationship: negatively_regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075251
name: uredospore formation
namespace: biological_process
def: "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus." [GOC:pamgo_curators]
synonym: "urediniospore formation" EXACT []
synonym: "ureidospore formation" EXACT []
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075252
name: regulation of uredospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
synonym: "regulation of ureidospore formation" EXACT []
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075251 ! uredospore formation

[Term]
id: GO:0075253
name: positive regulation of uredospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
synonym: "positive regulation of ureidospore formation" EXACT []
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075252 ! regulation of uredospore formation
relationship: positively_regulates GO:0075251 ! uredospore formation

[Term]
id: GO:0075254
name: negative regulation of uredospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
synonym: "negative regulation of ureidospore formation" EXACT []
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075252 ! regulation of uredospore formation
relationship: negatively_regulates GO:0075251 ! uredospore formation

[Term]
id: GO:0075255
name: teliospore formation
namespace: biological_process
def: "The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075256
name: regulation of teliospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075257
name: positive regulation of teliospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075256 ! regulation of teliospore formation
relationship: positively_regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075258
name: negative regulation of teliospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075256 ! regulation of teliospore formation
relationship: negatively_regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075259
name: spore-bearing structure development
namespace: biological_process
def: "The process whose specific outcome is the progression of a spore-bearing structure over time, from its formation to the mature structure. A spore-bearing structure is an anatomical structure that produces new spores." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]
synonym: "fruiting structure development" EXACT []
synonym: "sporangium development" BROAD []
synonym: "spore-bearing organ development" RELATED []
synonym: "sporophore development" EXACT []
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0075260
name: regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075261
name: positive regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0075260 ! regulation of spore-bearing organ development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075262
name: negative regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0075260 ! regulation of spore-bearing organ development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075263
name: oogonium development
namespace: biological_process
def: "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075264
name: regulation of oogonium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075265
name: positive regulation of oogonium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075264 ! regulation of oogonium development
relationship: positively_regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075266
name: negative regulation of oogonium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075264 ! regulation of oogonium development
relationship: negatively_regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075267
name: aecium development
namespace: biological_process
def: "The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium." [GOC:pamgo_curators]
is_a: GO:0030582 ! reproductive fruiting body development

[Term]
id: GO:0075268
name: regulation of aecium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0031155 ! regulation of reproductive fruiting body development
relationship: regulates GO:0075267 ! aecium development

[Term]
id: GO:0075269
name: positive regulation of aecium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075268 ! regulation of aecium development
relationship: positively_regulates GO:0075267 ! aecium development

[Term]
id: GO:0075270
name: negative regulation of aecium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075268 ! regulation of aecium development
relationship: negatively_regulates GO:0075267 ! aecium development

[Term]
id: GO:0075271
name: zygosporangium development
namespace: biological_process
def: "The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075272
name: regulation of zygosporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075273
name: positive regulation of zygosporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075272 ! regulation of zygosporangium development
relationship: positively_regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075274
name: negative regulation of zygosporangium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075272 ! regulation of zygosporangium development
relationship: negatively_regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075275
name: telium development
namespace: biological_process
def: "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075276
name: regulation of telium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075275 ! telium development

[Term]
id: GO:0075277
name: positive regulation of telium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075276 ! regulation of telium development
relationship: positively_regulates GO:0075275 ! telium development

[Term]
id: GO:0075278
name: negative regulation of telium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075276 ! regulation of telium development
relationship: negatively_regulates GO:0075275 ! telium development

[Term]
id: GO:0075279
name: uredinium development
namespace: biological_process
def: "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
synonym: "development of uredium" EXACT []
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075280
name: regulation of uredinium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075281
name: positive regulation of uredinium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075280 ! regulation of uredinium development
relationship: positively_regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075282
name: negative regulation of uredinium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075280 ! regulation of uredinium development
relationship: negatively_regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075283
name: sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure." [GOC:pamgo_curators]
synonym: "multicellular or syncytial spore formation by sporulation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043934 ! sporulation

[Term]
id: GO:0075284
name: asexual sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The formation of a multicellular or syncytial spore via septations derived from mitosis." [GOC:pamgo_curators]
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore

[Term]
id: GO:0075285
name: sexual sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators]
is_a: GO:0034293 ! sexual sporulation
is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore

[Term]
id: GO:0075286
name: regulation of sporangiospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075287
name: positive regulation of sporangiospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: positively_regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075288
name: negative regulation of sporangiospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: negatively_regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075289
name: aplanospore formation
namespace: biological_process
def: "The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075290
name: regulation of aplanospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075291
name: positive regulation of aplanospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075287 ! positive regulation of sporangiospore formation
is_a: GO:0075290 ! regulation of aplanospore formation
relationship: positively_regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075292
name: negative regulation of aplanospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075288 ! negative regulation of sporangiospore formation
is_a: GO:0075290 ! regulation of aplanospore formation
relationship: negatively_regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075293
name: response to host pH environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response of symbiont to host pH environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075294
name: positive regulation by symbiont of entry into host
namespace: biological_process
alt_id: GO:0075295
def: "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "activation by organism of entry into other organism during symbiotic interaction" NARROW []
synonym: "activation by symbiont of entry into host" NARROW []
synonym: "positive regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive regulation by organism of entry into other organism involved in symbiotic interaction" RELATED []
synonym: "up regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "up regulation by symbiont of entry into host" EXACT []
synonym: "up-regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by symbiont of entry into host" EXACT []
synonym: "upregulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "upregulation by symbiont of entry into host" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: positively_regulates GO:0044409 ! symbiont entry into host

[Term]
id: GO:0075296
name: positive regulation of ascospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0075297
name: negative regulation of ascospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
relationship: negatively_regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0075298
name: regulation of zygospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075299
name: positive regulation of zygospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075298 ! regulation of zygospore formation
relationship: positively_regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075300
name: negative regulation of zygospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075298 ! regulation of zygospore formation
relationship: negatively_regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075301
name: obsolete cell differentiation involved in spore germination
namespace: biological_process
def: "OBSOLETE. The process in which a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth." [GOC:jl]
comment: This term was made obsolete because it describes a process that doesn't exist.
is_obsolete: true

[Term]
id: GO:0075302
name: regulation of basidiospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075303
name: positive regulation of basidiospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075302 ! regulation of basidiospore formation
relationship: positively_regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075304
name: negative regulation of basidiospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075302 ! regulation of basidiospore formation
relationship: negatively_regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075305
name: obsolete modulation of growth or development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "modulation of growth or development of symbiont on or near host" EXACT []
synonym: "modulation of growth or development of symbiont on or near host surface" EXACT []
is_obsolete: true

[Term]
id: GO:0075306
name: regulation of conidium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075307
name: positive regulation of conidium formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0075306 ! regulation of conidium formation
is_a: GO:1903666 ! positive regulation of asexual reproduction
relationship: positively_regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075308
name: negative regulation of conidium formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0075306 ! regulation of conidium formation
is_a: GO:1903665 ! negative regulation of asexual reproduction
relationship: negatively_regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075309
name: obsolete negative regulation of growth or development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "negative regulation of growth or development of symbiont on or near host surface" EXACT []
is_obsolete: true

[Term]
id: GO:0075310
name: regulation of sporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075311
name: positive regulation of sporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075310 ! regulation of sporangium development
relationship: positively_regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075312
name: negative regulation of sporangium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075310 ! regulation of sporangium development
relationship: negatively_regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075313
name: basidium development
namespace: biological_process
def: "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]
comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked.
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075314
name: regulation of basidium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075313 ! basidium development

[Term]
id: GO:0075315
name: positive regulation of basidium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075314 ! regulation of basidium development
relationship: positively_regulates GO:0075313 ! basidium development

[Term]
id: GO:0075316
name: negative regulation of basidium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075314 ! regulation of basidium development
relationship: negatively_regulates GO:0075313 ! basidium development

[Term]
id: GO:0075317
name: ascus development
namespace: biological_process
def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]
comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked.
is_a: GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0075318
name: regulation of ascus development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075317 ! ascus development

[Term]
id: GO:0075319
name: positive regulation of ascus development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075318 ! regulation of ascus development
relationship: positively_regulates GO:0075317 ! ascus development

[Term]
id: GO:0075320
name: negative regulation of ascus development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075318 ! regulation of ascus development
relationship: negatively_regulates GO:0075317 ! ascus development

[Term]
id: GO:0075321
name: oomycete sporangium development
namespace: biological_process
def: "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0043582 ! sporangium development

[Term]
id: GO:0075322
name: regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0075310 ! regulation of sporangium development
relationship: regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075323
name: positive regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0075311 ! positive regulation of sporangium development
is_a: GO:0075322 ! regulation of oomycete sporangium development
is_a: GO:1903666 ! positive regulation of asexual reproduction
relationship: positively_regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075324
name: negative regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0075312 ! negative regulation of sporangium development
is_a: GO:0075322 ! regulation of oomycete sporangium development
is_a: GO:1903665 ! negative regulation of asexual reproduction
relationship: negatively_regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075325
name: spore dispersal
namespace: biological_process
alt_id: GO:0075326
alt_id: GO:0075327
def: "Any process in which an organism disseminates its spores." [Wikipedia:Spore]
synonym: "active spore dispersal on or near host" NARROW []
synonym: "active spore dispersal on or near host during symbiotic interaction" NARROW []
synonym: "passive spore dispersal on or near host" NARROW []
synonym: "spore dispersal on or near host" NARROW []
synonym: "spore dispersal on or near host during symbiotic interaction" EXACT []
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0075328
name: formation of arbuscule for nutrient acquisition
namespace: biological_process
def: "The assembly of an arbuscule, a fine, tree-like hyphal symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation by symbiont of arbuscule for nutrient acquisition from host" RELATED []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition

[Term]
id: GO:0075329
name: regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
is_a: GO:0060259 ! regulation of feeding behavior
relationship: regulates GO:0075328 ! formation of arbuscule for nutrient acquisition

[Term]
id: GO:0075330
name: positive regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process
is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host
relationship: positively_regulates GO:0075328 ! formation of arbuscule for nutrient acquisition

[Term]
id: GO:0075331
name: negative regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process
is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host
relationship: negatively_regulates GO:0075328 ! formation of arbuscule for nutrient acquisition

[Term]
id: GO:0075332
name: obsolete modulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075333
name: obsolete positive regulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway.
is_obsolete: true

[Term]
id: GO:0075334
name: obsolete modulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075335
name: obsolete positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075336
name: obsolete negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075337
name: obsolete positive regulation of growth or development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "positive regulation of growth or development of symbiont on or near host surface" EXACT []
is_obsolete: true

[Term]
id: GO:0075338
name: obsolete modulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "modulation of growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true
consider: GO:0044145

[Term]
id: GO:0075339
name: obsolete positive regulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "positive regulation of growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true

[Term]
id: GO:0075340
name: obsolete negative regulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or).
synonym: "negative regulation of growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true
consider: GO:0044147

[Term]
id: GO:0075341
name: host cell PML body
namespace: cellular_component
def: "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism." [GOC:BHF, GOC:jl]
synonym: "host cell PML NB" EXACT []
synonym: "host cell PML nuclear body" EXACT []
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0075342
name: symbiont-mediated disruption of host cell PML body
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:BHF, GOC:jl]
synonym: "catabolism by symbiont of host cell PML body" EXACT []
synonym: "degradation by symbiont of host cell PML body" EXACT []
synonym: "disassembly by symbiont of host cell PML body" EXACT []
synonym: "disassembly by symbiont of host cell PML body during symbiotic interaction" EXACT []
synonym: "disassembly by symbiont of host cell PML NB" EXACT []
synonym: "disassembly by symbiont of host cell PML nuclear body" EXACT []
synonym: "disruption by symbiont of host cell PML body" EXACT []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0075343
name: obsolete modulation by symbiont of abscisic acid levels in host
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0075344
name: obsolete modulation by symbiont of host protein levels
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
is_obsolete: true

[Term]
id: GO:0075345
name: obsolete modification by symbiont of host protein
namespace: biological_process
def: "OBSOLETE. The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0075346
name: obsolete modification by symbiont of host protein by ubiquitination
namespace: biological_process
def: "OBSOLETE. The process in which an organism adds one or more ubiquitin groups to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modification by symbiont of host protein by ubiquitinylation" EXACT []
synonym: "modification by symbiont of host protein by ubiquitylation" EXACT []
is_obsolete: true

[Term]
id: GO:0075502
name: endosome membrane permeabilization involved in viral entry into host cell
namespace: biological_process
alt_id: GO:0075518
def: "Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm." [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization" RELATED [GOC:bf, GOC:jl]
is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell

[Term]
id: GO:0075503
name: fusion of virus membrane with host macropinosome membrane
namespace: biological_process
def: "Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm." [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the endosome membrane" EXACT []
synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the host macropinosome membrane" RELATED [GOC:bf, GOC:jl]
is_a: GO:0039654 ! fusion of virus membrane with host endosome membrane

[Term]
id: GO:0075504
name: macropinosomal membrane permeabilization involved in viral entry into host cell
namespace: biological_process
def: "Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via macropinocytosis followed by macropinosomal membrane permeabilization" RELATED [GOC:bf, GOC:jl]
is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell

[Term]
id: GO:0075505
name: entry of intact viral capsid into host nucleus through nuclear pore complex
namespace: biological_process
def: "Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC)." [PMID:22929056, VZ:989]
comment: This mechanism is used by viruses with capsids small enough to cross the nuclear pore complex, such as the single-stranded (ss) DNA viruses Parvoviridae, Circoviridae and Geminiviridae.
is_a: GO:0075732 ! viral penetration into host nucleus

[Term]
id: GO:0075506
name: entry of viral genome into host nucleus through nuclear pore complex via importin
namespace: biological_process
def: "Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery." [PMID:22929056, VZ:989]
comment: This mechanism is used by some RNA viruses (e.g. Orthomyxoviridae), some dsDNA viruses (e.g. Polyomaviridae) and some ssRNA viruses (e.g. Lentivirus).
synonym: "entry of viral genome into host nucleus via cellular importin transport through the nuclear pore complex" EXACT [GOC:jl]
is_a: GO:0075732 ! viral penetration into host nucleus

[Term]
id: GO:0075507
name: entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome
namespace: biological_process
def: "Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm." [PMID:22929056, VZ:989]
comment: This mechanism is used by viruses such as Herpesvirales whose capsid is too large to enter the nuclear pore complex (NPC) pore.
is_a: GO:0075732 ! viral penetration into host nucleus

[Term]
id: GO:0075508
name: entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm
namespace: biological_process
def: "Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm." [PMID:22929056, VZ:989]
comment: This mechanism is used by viruses such as Hepadnaviridae whose capsids enter the NPC but are too big to pass intact into the nucleus.
synonym: "entry of viral genome into host nucleus via attachment of capsid to nuclear pore complex and release of genome into nucleoplasm" EXACT [GOC:jl]
is_a: GO:0075732 ! viral penetration into host nucleus

[Term]
id: GO:0075509
name: endocytosis involved in viral entry into host cell
namespace: biological_process
def: "Any endocytosis that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, VZ:977]
synonym: "viral entry into host cell via endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral penetration via endocytosis followed by endosome disruption" EXACT []
synonym: "virus endocytosis by host" EXACT [UniProtKB-KW:KW-1164]
xref: VZ:977 "Virus endocytosis by host"
is_a: GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0075510
name: macropinocytosis involved in viral entry into host cell
namespace: biological_process
def: "Any macropinocytosis that is involved in the uptake of a virus into a host cell." [GOC:jl, GOC:sp, PMID:17077125, PMID:19404330, VZ:800]
synonym: "viral entry into host cell via macropinocytosis" RELATED [GOC:bf, GOC:jl]
xref: VZ:800 "Macropinocytosis of virus by host"
is_a: GO:0075509 ! endocytosis involved in viral entry into host cell

[Term]
id: GO:0075511
name: macropinosome lysis involved in viral entry into host cell
namespace: biological_process
def: "Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl]
is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell

[Term]
id: GO:0075512
name: clathrin-dependent endocytosis of virus by host cell
namespace: biological_process
alt_id: GO:0075516
def: "Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus." [GOC:bf, GOC:jl, VZ:957]
synonym: "clathrin-mediated endocytosis of virus by host cell" EXACT []
synonym: "viral entry into host cell via clathrin-mediated endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis" NARROW []
synonym: "viral penetration via clathrin-mediated endocytosis" EXACT [GOC:sp]
xref: VZ:957 "Clathrin-mediated endocytosis of virus by host"
is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell
is_a: GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:0075513
name: caveolin-mediated endocytosis of virus by host cell
namespace: biological_process
def: "Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus." [GOC:bf, GOC:jl, VZ:976]
synonym: "viral entry into host cell via caveolae-mediated endocytosis" EXACT [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolin-mediated endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral penetration via caveolae-mediated endocytosis followed by endosome disruption" EXACT []
xref: VZ:976 "Caveolin-mediated endocytosis of virus by host"
is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell
is_a: GO:0072584 ! caveolin-mediated endocytosis

[Term]
id: GO:0075514
name: endosome lysis involved in viral entry into host cell
namespace: biological_process
def: "Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm." [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome lysis" EXACT [GOC:bf, GOC:jl]
is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell

[Term]
id: GO:0075515
name: obsolete viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane
namespace: biological_process
def: "OBSOLETE. The uptake of a virus into a host cell that begins when material is taken up into plasma membrane caveolae which then pinch off to form endocytic caveolar carriers containing the virus. The caveolar carriers then deliver their viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl, VZ:976]
comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis.
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0075519
name: microtubule-dependent intracellular transport of viral material
namespace: biological_process
def: "The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus." [VZ:983]
is_a: GO:0075733 ! intracellular transport of virus

[Term]
id: GO:0075520
name: actin-dependent intracellular transport of virus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions." [UniProtKB-KW:KW-1178, VZ:991]
synonym: "actin-dependent intracellular transport of viral material" EXACT []
xref: VZ:991 "Actin-dependent inwards viral transport"
is_a: GO:0075733 ! intracellular transport of virus

[Term]
id: GO:0075521
name: microtubule-dependent intracellular transport of viral material towards nucleus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983]
synonym: "microtubule-dependent intracellular transport of viral material to nucleus" EXACT [GOC:jl]
xref: VZ:983 "Microtubular inwards viral transport"
is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material
is_a: GO:0075606 ! transport of viral material towards nucleus

[Term]
id: GO:0075522
name: IRES-dependent viral translational initiation
namespace: biological_process
def: "Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation." [GOC:bf, GOC:jl, PMID:19632368, VZ:867]
xref: VZ:867 "Viral initiation of translation: IRES and DLP"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019081 ! viral translation

[Term]
id: GO:0075523
name: viral translational frameshifting
namespace: biological_process
def: "A process which occurs during viral translation, which involves a translational recoding mechanism called programmed ribosomal frameshifting. This causes the ribosome to alter its reading of the mRNA to an a different open reading frame to produce alternate viral proteins." [GOC:bf, GOC:ch, GOC:jl, PMID:24825891, PMID:8852897, VZ:860]
comment: This term is intended to annotate gene products involved in the process of viral translational frameshifting, not viral proteins produced by this translation process.
synonym: "ribosomal frameshifting involved in viral translation" EXACT [GOC:jl]
xref: VZ:860 "Ribosomal frameshifting"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019081 ! viral translation

[Term]
id: GO:0075524
name: ribosomal skipping
namespace: biological_process
def: "A translation process in which a specific viral peptide prevents the ribosome from covalently linking a new inserted amino acid, and lets it continue translation, thereby cleaving the nascent protein while allowing translation to continue." [GOC:bf, GOC:ch, GOC:jl, VZ:914]
comment: This term is intended to annotate gene products involved in the process of ribosomal skipping, not viral proteins produced by this translation process.
xref: VZ:914 "Ribosomal skipping"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019081 ! viral translation

[Term]
id: GO:0075525
name: viral translational termination-reinitiation
namespace: biological_process
def: "A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF." [GOC:bf, GOC:ch, GOC:jl, PMID:18631147, PMID:18824510, VZ:858]
comment: This term is intended to annotate gene products involved in the process of viral translational termination-reinitiation, not viral proteins produced by this translation process.
synonym: "termination reinitiation involved in viral translation" EXACT [GO:jl]
synonym: "viral translation involving termination re-initiation" EXACT [GO:jl]
synonym: "viral translation involving termination-reinitiation" EXACT [GO:jl]
synonym: "viral translation involving translational stop-start" EXACT [GO:jl]
xref: VZ:858 "RNA termination-reinitiation"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019081 ! viral translation

[Term]
id: GO:0075526
name: cap snatching
namespace: biological_process
def: "A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs." [GOC:bf, GOC:jl, VZ:839]
synonym: "cap snatching involved in viral mRNA transcription" EXACT [GO:jl]
xref: VZ:839 "Cap snatching"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0039697 ! negative stranded viral RNA transcription

[Term]
id: GO:0075527
name: viral RNA editing
namespace: biological_process
def: "The process by which bases in viral mRNA are chemically altered during viral transcription. This is usually the incorporation of 1 - 6 additional nucleotides, which shifts the reading frame, allowing the generation of different protein products or through a specific nucleotide change that eliminates the termination codon." [PMID:1629949, VZ:857]
synonym: "RNA editing involved in viral mRNA transcription" EXACT [GO:jl]
xref: VZ:857 "RNA editing"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019083 ! viral transcription

[Term]
id: GO:0075528
name: obsolete perturbation by virus of host immune response
namespace: biological_process
def: "OBSOLETE. A process in which a virus effects a change in the host immune response." [GOC:bf, GOC:jl]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host innate immune response ; GO:0052170.
synonym: "regulation by virus of host immune system process" EXACT [GOC:jl]
is_obsolete: true
replaced_by: GO:0052170

[Term]
id: GO:0075529
name: establishment of latency as a circular episome
namespace: biological_process
def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure." [GOC:jl]
synonym: "establishment of circular plasmid latency" EXACT []
synonym: "establishment of latency as a circular plasmid" EXACT []
is_a: GO:0075720 ! establishment of episomal latency

[Term]
id: GO:0075530
name: establishment of latency as a linear episome
namespace: biological_process
def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure." [GOC:jl]
synonym: "establishment of latency as a linear plasmid" EXACT []
synonym: "establishment of linear plasmid latency" EXACT []
is_a: GO:0075720 ! establishment of episomal latency

[Term]
id: GO:0075606
name: transport of viral material towards nucleus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane." [GOC:bf, GOC:jl, VZ:990]
comment: This process does not include the viral material crossing the nuclear membrane. For transport of viral material into the nucleus, consider instead: 'viral penetration into host nucleus ; GO:0075732'.
synonym: "cytoplasmic inwards viral transport" EXACT [UniProtKB-KW:KW-1176, VZ:990]
synonym: "transport of viral material to nucleus" EXACT [GOC:jl]
synonym: "viral genome transport to host cell nucleus" EXACT []
xref: VZ:990 "Cytoplasmic inwards viral transport"
is_a: GO:0075733 ! intracellular transport of virus

[Term]
id: GO:0075705
name: obsolete viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane
namespace: biological_process
def: "OBSOLETE. The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when the viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl]
comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis.
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT []
synonym: "viral penetration via endocytosis followed by genetic injection through the endosome membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0075713
name: establishment of integrated proviral latency
namespace: biological_process
alt_id: GO:0019047
def: "A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage." [GOC:jl]
synonym: "prophage integration" EXACT []
synonym: "provirus integration" EXACT []
xref: VZ:980 "Viral genome integration"
is_a: GO:0019043 ! establishment of viral latency

[Term]
id: GO:0075720
name: establishment of episomal latency
namespace: biological_process
def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity." [GOC:jl]
synonym: "establishment as a plasmid prophage" NARROW []
synonym: "establishment of plasmid latency" EXACT []
is_a: GO:0019043 ! establishment of viral latency

[Term]
id: GO:0075732
name: viral penetration into host nucleus
namespace: biological_process
def: "The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid." [PMID:22929056, VZ:989]
synonym: "viral entry into host nucleus" EXACT []
synonym: "viral import into host nucleus" EXACT []
xref: VZ:989 "Viral penetration into host nucleus"
is_a: GO:0075733 ! intracellular transport of virus

[Term]
id: GO:0075733
name: intracellular transport of virus
namespace: biological_process
alt_id: GO:0046788
alt_id: GO:0046795
alt_id: GO:0046796
def: "The directed movement of a virus, or part of a virus, within the host cell." [GOC:ai, GOC:bf, GOC:jl, PMID:11733033]
synonym: "egress of virus within host cell" EXACT []
synonym: "intracellular transport of viral material" EXACT [GOC:bf, GOC:jl]
synonym: "intracellular virion transport" RELATED []
synonym: "movement of virus within host cell" EXACT []
synonym: "viral egress" RELATED []
synonym: "viral genome transport in host cell" EXACT []
is_a: GO:0044403 ! biological process involved in symbiotic interaction
is_a: GO:0046794 ! transport of virus
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0080001
name: mucilage extrusion from seed coat
namespace: biological_process
def: "The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat." [PMID:18266922]
synonym: "mucilage release from seed coat" RELATED []
synonym: "secretion of mucilage from seed coat" RELATED []
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0009845 ! seed germination
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0080002
name: UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + UDP-alpha-D-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP." [MetaCyc:RXN-6142, PMID:18385129]
synonym: "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity" RELATED []
synonym: "UDP-glucose:p-aminobenzoate glucosyltransferase activity" RELATED []
synonym: "UDP-glucose:pABA acylglucosyltransferase activity" RELATED []
xref: MetaCyc:RXN-6142
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080003
name: thalianol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the triterpene thalianol." [PMID:18356490]
synonym: "thalianol metabolism" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process

[Term]
id: GO:0080004
name: thalian-diol desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15." [PMID:18356490]
xref: MetaCyc:RXN-9637
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080005
name: photosystem stoichiometry adjustment
namespace: biological_process
def: "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis." [PMID:11607105]
is_a: GO:0010109 ! regulation of photosynthesis

[Term]
id: GO:0080006
name: internode patterning
namespace: biological_process
def: "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached." [GOC:tb]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0080007
name: S-nitrosoglutathione reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-nitrosoglutathione + NADH + H+ = S-(hydroxysulfenamide)glutathione + NAD+." [PMID:11260719, PMID:27094420, PMID:30795534]
comment: S-(hydroxysulfenamide)glutathione (GSNHOH) is an unstable intermediate. At high GSH levels, it is decomposed to glutathione disulfide (GSSG) and hydroxylamine. At low GSH levels, GSNHOH spontaneously converts to glutathione sulfinamid (GSONH2), which can be hydrolyzed to glutathione sulfinic acid (GSOOH) and ammonia. {xref="PMID:30795534"}
xref: MetaCyc:RXN-17884
xref: RHEA:78371
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0080008
name: Cul4-RING E3 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0080009
name: obsolete mRNA methylation
namespace: biological_process
def: "OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0016556

[Term]
id: GO:0080010
name: obsolete regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [PMID:18450450]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "regulation of oxygen and reactive oxygen species metabolic process" EXACT []
is_obsolete: true
consider: GO:2000374
consider: GO:2000377

[Term]
id: GO:0080011
name: baruol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol." [PMID:17705488, RHEA:31987]
xref: EC:5.4.99.57
xref: MetaCyc:RXN-9685
xref: RHEA:31987
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0080012
name: trihydroxyferuloyl spermidine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+." [PMID:18557837]
synonym: "N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity" EXACT [MetaCyc:RXN-11263]
xref: MetaCyc:RXN-11263
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080013
name: (E,E)-geranyllinalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [MetaCyc:RXN-10441, PMID:18398052]
xref: MetaCyc:RXN-10441
xref: RHEA:38155
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0080014
name: thalianol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X." [MetaCyc:RXN-9631, PMID:17474751, PMID:18356490]
comment: In Field and Osbourn 2008 (PMID:18356490), thalianol is referred to as (3S,13S,3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S,13S,14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID:17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008).
xref: MetaCyc:RXN-9631
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0080015
name: sabinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E)-geranyl diphosphate = diphosphate + sabinene." [PMID:12566586, PMID:9747540, RHEA:68636]
xref: MetaCyc:RXN-5103
xref: RHEA:68636
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0080016
name: (-)-E-beta-caryophyllene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047]
xref: EC:4.2.3.57
xref: MetaCyc:RXN-8414
xref: RHEA:28294
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0080017
name: alpha-humulene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047, RHEA:31895]
xref: EC:4.2.3.104
xref: MetaCyc:RXN-8415
xref: RHEA:31895
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0080018
name: anthocyanin 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP." [PMID:15807784]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080019
name: alcohol-forming very long-chain fatty acyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:16980563]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "fatty acyl CoA reductase (alcohol-forming) activity" EXACT []
synonym: "fatty acyl-CoA reductase (alcohol-forming) activity" EXACT [GOC:mah]
synonym: "fatty-acyl-CoA reductase (alcohol-forming) activity" RELATED []
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0080020
name: regulation of coenzyme A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0015937 ! coenzyme A biosynthetic process

[Term]
id: GO:0080021
name: response to benzoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285]
synonym: "response to benzoic acid stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080022
name: primary root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle." [GOC:dhl]
is_a: GO:0048364 ! root development

[Term]
id: GO:0080023
name: obsolete (3R)-3-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [PMID:16982622, RHEA:26526]
comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
synonym: "3R-hydroxyacyl-CoA dehydratase activity" EXACT []
is_obsolete: true
replaced_by: GO:0018812

[Term]
id: GO:0080024
name: indolebutyric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants." [PMID:18725356]
synonym: "IBA metabolic process" EXACT []
synonym: "IBA metabolism" EXACT []
synonym: "indole-3-butyric acid metabolic process" NARROW []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0080025
name: phosphatidylinositol-3,5-bisphosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]
synonym: "PtdIns(3,5)P2 binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding

[Term]
id: GO:0080026
name: response to indolebutyric acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [PMID:18725356]
synonym: "response to IBA stimulus" EXACT []
synonym: "response to indole-3-butyric acid stimulus" NARROW []
synonym: "response to indolebutyric acid stimulus" EXACT [GOC:dos]
is_a: GO:0009733 ! response to auxin
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080027
name: response to herbivore
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore." [PMID:18987211]
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0080028
name: nitrile biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [PMID:18987211]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0080029
name: cellular response to boron-containing substance levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances." [PMID:18952773]
synonym: "cellular response to boron levels" EXACT []
is_a: GO:0010036 ! response to boron-containing substance
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0080030
name: methyl indole-3-acetate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + methyl (indol-3-yl)acetate = (indol-3-yl)acetate + H+ + methanol." [PMID:18467465, RHEA:32919]
synonym: "indole-3-Acetic acid methyl ester esterase activity" EXACT []
synonym: "MeIAA esterase activity" EXACT []
synonym: "Methyl IAA esterase activity" EXACT []
xref: MetaCyc:RXN-10711
xref: RHEA:32919
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0080031
name: methyl salicylate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + methyl salicylate = H+ + methanol + salicylate." [PMID:18467465, PMID:18643994, RHEA:33611]
synonym: "MESA esterase activity" EXACT []
synonym: "methyl SA esterase activity" EXACT []
synonym: "methylsalicylate esterase activity" EXACT []
synonym: "salicylic acid methyl ester esterase activity" EXACT []
xref: MetaCyc:RXNQT-4366
xref: RHEA:33611
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0080032
name: methyl jasmonate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + methyl (-)-jasmonate = H+ + jasmonate + methanol." [PMID:15233793, PMID:18467465, RHEA:55372]
synonym: "jasmonic acid methyl ester esterase activity" EXACT []
synonym: "MEJA esterase activity" EXACT []
synonym: "methyl JA esterase activity" EXACT []
xref: MetaCyc:RXN-10767
xref: RHEA:55372
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0080033
name: response to nitrite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:dhl, PMID:17951451]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080034
name: host response to induction by symbiont of tumor, nodule or growth in host
namespace: biological_process
def: "Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18836040]
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0080035
name: 2-hydroxy-but-3-enyl glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables." [PMID:11560911, PMID:18945935]
synonym: "2-hydroxy-but-3-enyl glucosinolate anabolism" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate biosynthesis" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate formation" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate synthesis" EXACT []
synonym: "progoitrin biosynthesis" EXACT []
synonym: "progoitrin biosynthetic process" EXACT []
synonym: "progoitrin synthesis" EXACT []
is_a: GO:0019761 ! glucosinolate biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0080036
name: regulation of cytokinin-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokinin signaling." [GOC:dhl]
synonym: "regulation of cytokinin mediated signaling pathway" RELATED []
synonym: "regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0009736 ! cytokinin-activated signaling pathway

[Term]
id: GO:0080037
name: negative regulation of cytokinin-activated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinin signaling." [GOC:dhl, PMID:14973166]
synonym: "negative regulation of cytokinin mediated signaling pathway" RELATED []
synonym: "negative regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway
relationship: negatively_regulates GO:0009736 ! cytokinin-activated signaling pathway

[Term]
id: GO:0080038
name: positive regulation of cytokinin-activated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokinin signaling." [GOC:dhl]
synonym: "positive regulation of cytokinin mediated signaling pathway" RELATED []
synonym: "positive regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway
relationship: positively_regulates GO:0009736 ! cytokinin-activated signaling pathway

[Term]
id: GO:0080040
name: positive regulation of cellular response to phosphate starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation." [PMID:18315545]
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0140255 ! regulation of cellular response to phosphate starvation
relationship: positively_regulates GO:0016036 ! cellular response to phosphate starvation

[Term]
id: GO:0080041
name: ADP-ribose pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate." [GOC:tb]
is_a: GO:0019144 ! ADP-sugar diphosphatase activity

[Term]
id: GO:0080042
name: ADP-glucose pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate." [GOC:tb]
is_a: GO:0019144 ! ADP-sugar diphosphatase activity

[Term]
id: GO:0080043
name: quercetin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080044
name: quercetin 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080045
name: quercetin 3'-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080046
name: quercetin 4'-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule." [PMID:15352060]
xref: MetaCyc:RXN-10788
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080047
name: GDP-L-galactose phosphorylase activity
namespace: molecular_function
alt_id: GO:0010475
def: "Catalysis of the reaction: GDP-beta-L-galactose + phosphate = beta-L-galactose-1-phosphate + GDP." [PMID:17462988, PMID:18463094, RHEA:27698]
synonym: "galactose-1-phosphate guanylyltransferase (GDP) activity" EXACT []
synonym: "GDP:galactose-1-phosphate guanyltransferase activity" EXACT []
xref: EC:2.7.7.69
xref: MetaCyc:RXNQT-4141
xref: RHEA:27698
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0080048
name: GDP-D-glucose phosphorylase activity
namespace: molecular_function
alt_id: GO:0010474
def: "Catalysis of the reaction: GDP-alpha-D-glucose + phosphate = alpha-D-glucose-1-phosphate + GDP." [PMID:17462988, PMID:18463094]
synonym: "GDP:glucose-1-phosphate guanyltransferase activity" EXACT []
synonym: "glucose-1-phosphate guanylyltransferase (GDP) activity" EXACT []
xref: EC:2.7.7.78
xref: MetaCyc:RXN-12486
xref: RHEA:30387
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0080049
name: L-gulono-1,4-lactone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [PMID:18190525, PMID:30112455, RHEA:47248]
xref: MetaCyc:RXN-1439
xref: RHEA:47248
is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor

[Term]
id: GO:0080050
name: regulation of seed development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed development." [PMID:19141706]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0048316 ! seed development

[Term]
id: GO:0080051
name: cutin transport
namespace: biological_process
def: "The directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface." [PMID:17951461]
is_a: GO:0006810 ! transport

[Term]
id: GO:0080052
name: response to histidine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [PMID:15889294]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080053
name: response to phenylalanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [PMID:15889294]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080054
name: low-affinity nitrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168]
synonym: "low affinity nitrate transmembrane transporter activity" EXACT []
is_a: GO:0015112 ! nitrate transmembrane transporter activity

[Term]
id: GO:0080056
name: petal vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the petal of vascular plants." [PMID:17369435]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0080057
name: sepal vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the sepal of vascular plants." [PMID:17369435]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0080058
name: protein deglutathionylation
namespace: biological_process
def: "The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage." [GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "protein amino acid deglutathionylation" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0080059
name: flavonol 3-O-arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside." [PMID:18757557]
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0052636 ! arabinosyltransferase activity

[Term]
id: GO:0080060
name: integument development
namespace: biological_process
def: "The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex." [PMID:19054366, PO:0020021]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048481 ! plant ovule development

[Term]
id: GO:0080061
name: indole-3-acetonitrile nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3." [RHEA:45776]
xref: MetaCyc:RXN-1404
xref: RHEA:45776
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0080062
name: cytokinin 9-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [KEGG_REACTION:R08369, PMID:15342621]
xref: KEGG_REACTION:R08369
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080064
name: 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation
namespace: biological_process
def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780]
synonym: "4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity" RELATED []
is_a: GO:0034440 ! lipid oxidation

[Term]
id: GO:0080065
name: 4-alpha-methyl-delta7-sterol oxidation
namespace: biological_process
def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780]
synonym: "4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity" RELATED []
is_a: GO:0034440 ! lipid oxidation

[Term]
id: GO:0080066
name: obsolete 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
comment: This term was obsoleted because it represents a specific substrate of aliphatic desulfoglucosinolate sulfotransferase activity ; GO:0120527.
is_obsolete: true
replaced_by: GO:0120527

[Term]
id: GO:0080067
name: obsolete 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
comment: This term was obsoleted because it represents a specific substrate of aliphatic desulfoglucosinolate sulfotransferase activity ; GO:0120527.
is_obsolete: true
replaced_by: GO:0120527

[Term]
id: GO:0080068
name: obsolete 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
comment: This term was obsoleted because it represents a specific substrate of aliphatic desulfoglucosinolate sulfotransferase activity ; GO:0120527.
is_obsolete: true
replaced_by: GO:0120527

[Term]
id: GO:0080069
name: obsolete 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
comment: This term was obsoleted because it represents a specific substrate of aliphatic desulfoglucosinolate sulfotransferase activity ; GO:0120527.
is_obsolete: true
replaced_by: GO:0120527

[Term]
id: GO:0080070
name: obsolete 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
comment: This term was obsoleted because it represents a specific substrate of aliphatic desulfoglucosinolate sulfotransferase activity ; GO:0120527.
is_obsolete: true
replaced_by: GO:0120527

[Term]
id: GO:0080071
name: obsolete indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
comment: This term was obsoleted because it represents the same activity as aromatic desulfoglucosinolate sulfotransferase activity ; GO:0047364.
is_obsolete: true
replaced_by: GO:0047364

[Term]
id: GO:0080072
name: spermidine:sinapoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080073
name: spermidine:coumaroyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080074
name: spermidine:caffeoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080075
name: spermidine:feruloyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080076
name: caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080077
name: trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080078
name: tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080079
name: cellobiose glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose." [PMID:15604686, RHEA:30679]
synonym: "cellobiose glucohydrolase activity" EXACT []
synonym: "D-cellobiose glucosidase activity" EXACT []
xref: MetaCyc:RXN-10773
xref: RHEA:30679
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0080081
name: 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside." [PMID:15604686]
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0080082
name: esculin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in esculin." [PMID:15604686]
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0080083
name: beta-gentiobiose beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose." [PMID:15604686]
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0080084
name: 5S rDNA binding
namespace: molecular_function
def: "Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists." [PMID:12711688]
is_a: GO:0000182 ! rDNA binding

[Term]
id: GO:0080085
name: signal recognition particle, chloroplast targeting
namespace: cellular_component
def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast." [PMID:17513500]
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0080086
name: stamen filament development
namespace: biological_process
def: "The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen." [PMID:19139039, PO:0009067]
synonym: "filament development" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0080088
name: spermidine hydroxycinnamate conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates." [PMID:19077165]
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0080089
name: sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative." [PMID:19168716]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080090
name: regulation of primary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0044238 ! primary metabolic process

[Term]
id: GO:0080091
name: regulation of raffinose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose." [PMID:19211694]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
relationship: regulates GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0080092
name: regulation of pollen tube growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pollen tube growth." [PMID:19208902]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0051510 ! regulation of unidimensional cell growth
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0009860 ! pollen tube growth

[Term]
id: GO:0080093
name: regulation of photorespiration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved." [GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0009853 ! photorespiration

[Term]
id: GO:0080094
name: response to trehalose-6-phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [PMID:19193861]
synonym: "response to trehalose-6-phosphate stimulus" EXACT [GOC:dos]
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080095
name: phosphatidylethanolamine-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine." [PMID:16020547]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0080096
name: phosphatidate-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate." [PMID:16020547]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0080097
name: L-tryptophan:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine." [RHEA:27586]
xref: EC:2.6.1.99
xref: MetaCyc:RXN-10139
xref: RHEA:27586
is_a: GO:0070529 ! L-tryptophan aminotransferase activity

[Term]
id: GO:0080098
name: L-tyrosine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine." [MetaCyc:RXN3O-4157]
synonym: "L-tyrosine aminotransferase activity" BROAD []
synonym: "L-tyrosine:pyruvate aminotransferase activity" EXACT []
xref: MetaCyc:RXN3O-4157
is_a: GO:0008793 ! aromatic-amino-acid transaminase activity

[Term]
id: GO:0080099
name: L-methionine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate." [PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.5 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.5).
synonym: "L-methionine:alpha-ketoglutarate aminotransferase activity" EXACT []
is_a: GO:0010326 ! methionine-oxo-acid transaminase activity

[Term]
id: GO:0080100
name: obsolete L-glutamine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate." [PMID:18394996]
comment: This term was obsoleted because it is a specific substrate of L-tryptophan:2-oxoglutarate aminotransferase activity ; GO:0050362.
synonym: "L-glutamine:alpha-ketoglutarate aminotransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0050362

[Term]
id: GO:0080101
name: obsolete phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine." [PMID:19366698]
comment: This term was obsoleted because it represents a specific substrate of phosphatidyl-N-methylethanolamine N-methyltransferase ; GO:0000773.
is_obsolete: true
replaced_by: GO:0000773

[Term]
id: GO:0080102
name: 3-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
xref: MetaCyc:RXN-2221
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080103
name: 4-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080104
name: 5-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080105
name: 6-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080106
name: 7-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080107
name: 8-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080108
name: S-alkylthiohydroximate lyase activity
namespace: molecular_function
def: "Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate." [PMID:14871316]
synonym: "S-alkylthiohydroximate C-S lyase activity" NARROW []
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0080109
name: indole-3-acetonitrile nitrile hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide." [MetaCyc:RXN-7567, PMID:11607511, PMID:12430025]
xref: KEGG_REACTION:R04020
xref: MetaCyc:RXN-7567
is_a: GO:0018822 ! nitrile hydratase activity

[Term]
id: GO:0080110
name: sporopollenin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer." [PMID:19218397]
synonym: "sporopollenin biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
relationship: part_of GO:0010584 ! pollen exine formation

[Term]
id: GO:0080111
name: obsolete DNA demethylation
namespace: biological_process
def: "OBSOLETE. The removal of a methyl group from one or more nucleotides within an DNA molecule." [PMID:17208187]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0141166
consider: GO:0141167
consider: GO:0141168
consider: GO:0141169

[Term]
id: GO:0080112
name: seed growth
namespace: biological_process
def: "The increase in size or mass of a seed. A seed is a propagating organ formed in the reproductive cycle of a spermatophyte, derived from the ovule and enclosing an embryo." [GOC:dhl, PO:0009010]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0080113
name: regulation of seed growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the seed of an plant." [PMID:19141706]
synonym: "regulation of seed size" EXACT []
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0080112 ! seed growth

[Term]
id: GO:0080114
name: obsolete positive regulation of glycine hydroxymethyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [PMID:19223513]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0080115
name: myosin XI tail binding
namespace: molecular_function
def: "Binding to the tail region of a myosin XI heavy chain." [PMID:18703495]
is_a: GO:0032029 ! myosin tail binding

[Term]
id: GO:0080116
name: glucuronoxylan glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule." [PMID:18980649]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0080117
name: secondary growth
namespace: biological_process
def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium." [ISBN:0471245208, PMID:19074290, PO:0005598, PO:0025004]
comment: Occurs in vascular plants, including gymnosperms and most dicotyledons. Commonly supplemented by activity of the cork cambium or phellogen (PO:0005599). Monocotyledons do not have secondary growth, but may undergo primary thickening (GO:0080192) or secondary thickening (GO:0080191), which can give the appearance of secondary growth. Primary and secondary growth can occur simultaneously in the same organism.
synonym: "cambial secondary growth" EXACT []
is_a: GO:0080190 ! lateral growth

[Term]
id: GO:0080118
name: brassinosteroid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative." [PMID:10409637, PMID:17039368]
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0080119
name: ER body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:18780803, PMID:19147648]
synonym: "endoplasmic reticulum body organization" EXACT []
synonym: "endoplasmic reticulum body organization and biogenesis" RELATED [GOC:mah]
synonym: "ER body organisation" EXACT [GOC:mah]
synonym: "ER body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0080120
name: CAAX-box protein maturation
namespace: biological_process
def: "A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase." [PMID:12039957, PMID:17114793, PMID:18641086]
synonym: "CAAX-box protein processing" RELATED []
synonym: "farnesylated protein maturation" RELATED [GOC:vw]
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0080121
name: AMP transport
namespace: biological_process
def: "The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18923018]
synonym: "adenosine monophosphate transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0080122
name: AMP transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other." [PMID:18923018]
synonym: "adenosine monophosphate transmembrane transporter activity" EXACT []
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity

[Term]
id: GO:0080123
name: jasmonoyl-L-amino acid ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H+. In Arabidopsis, isoleucine is the principal amino acid that conjugates with JA to form JA (JA-Ile). Other amino acid can be conjugated with JA such as valine, leucine, and phenylalanine." [PMID:15258265, PMID:17291501, PMID:33821356, RHEA:55772]
synonym: "ja-amino synthetase activity" EXACT []
synonym: "jasmonate-amido synthetase activity" EXACT []
synonym: "jasmonate-amino acid conjugate synthetase activity" EXACT []
synonym: "jasmonate-amino acid synthetase activity" EXACT []
synonym: "jasmonate-amino synthetase activity" EXACT []
synonym: "jasmonate:amino acid synthetase activity" EXACT []
synonym: "jasmonic acid-amino synthetase activity" EXACT []
synonym: "jasmonyl-amino synthetase activity" EXACT []
xref: EC:6.3.2.52
xref: RHEA:55772
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0080124
name: pheophytinase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide." [PMID:19304936]
synonym: "pheophytin pheophorbide hydrolase activity" EXACT []
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0080125
name: obsolete multicellular structure septum development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of the multicellular structure septum over time, from its formation to the mature structure. The multicellular structure septum is the thin partition or membrane that divides a cavity or a mass of tissue." [GOC:dhl]
comment: This term was made obsolete because it is not a useful grouping term.
is_obsolete: true

[Term]
id: GO:0080126
name: ovary septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)." [PMID:17855426]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:1905328 ! plant septum development
relationship: part_of GO:0035670 ! plant-type ovary development

[Term]
id: GO:0080127
name: fruit septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit." [GOC:dhl, PO:0005008]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009791 ! post-embryonic development
is_a: GO:1905328 ! plant septum development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0080128
name: anther septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone." [GOC:dhl, PO:0005010]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:1905328 ! plant septum development
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0080129
name: proteasome core complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [PMID:12401807, PMID:17971041]
synonym: "20S proteasome assembly" EXACT []
is_a: GO:0043248 ! proteasome assembly

[Term]
id: GO:0080130
name: L-phenylalanine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = 3-phenylpyruvate + L-glutamate." [PMID:18394996, RHEA:25152]
synonym: "L-phenylalanine:2-oxoglutarate aminotransferase activity" EXACT []
synonym: "L-phenylalanine:alpha-ketoglutarate aminotransferase activity" EXACT []
xref: KEGG_REACTION:R00694
xref: MetaCyc:RXN-10814
xref: RHEA:25152
is_a: GO:0008793 ! aromatic-amino-acid transaminase activity

[Term]
id: GO:0080131
name: hydroxyjasmonate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate." [EC:2.8.2.39, PMID:12637544]
synonym: "11-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10453]
synonym: "11-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10453]
synonym: "11-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10453]
synonym: "12-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10451]
synonym: "12-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10451]
synonym: "12-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10451]
synonym: "hydroxyjasmonic acid sulfotransferase activity" EXACT []
synonym: "OHJA sulfotransferase activity" EXACT []
xref: EC:2.8.2.39
xref: MetaCyc:RXN-10451
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0080132
name: fatty acid 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of the C-2 position in a fatty acid. The 2-hydroxylation may occur on free fatty acids or within the fatty acyl chain of a sphingolipid." [PMID:36902339]
synonym: "fatty acid alpha-hydroxylase activity" EXACT []
xref: Reactome:R-HSA-5693761 "FA2H hydroxylates 1,2-saturated fatty acids"
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0080133
name: midchain alkane hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of an alkane to a secondary alcohol." [PMID:17905869]
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0080134
name: regulation of response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0006950 ! response to stress

[Term]
id: GO:0080135
name: regulation of cellular response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0033554 ! cellular response to stress

[Term]
id: GO:0080136
name: priming of cellular response to stress
namespace: biological_process
def: "The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress." [PMID:19318610]
synonym: "priming of response to stress" BROAD []
synonym: "priming of stress response" BROAD []
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0080139
name: borate efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane." [PMID:18603465]
synonym: "boron efflux transmembrane transporter activity" RELATED []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0080140
name: regulation of jasmonic acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
relationship: regulates GO:0009694 ! jasmonic acid metabolic process

[Term]
id: GO:0080141
name: regulation of jasmonic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0080140 ! regulation of jasmonic acid metabolic process
relationship: regulates GO:0009695 ! jasmonic acid biosynthetic process

[Term]
id: GO:0080142
name: regulation of salicylic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0010337 ! regulation of salicylic acid metabolic process
relationship: regulates GO:0009697 ! salicylic acid biosynthetic process

[Term]
id: GO:0080143
name: regulation of amino acid export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle." [PMID:20018597]
is_a: GO:1903789 ! regulation of amino acid transmembrane transport
relationship: regulates GO:0032973 ! amino acid export across plasma membrane

[Term]
id: GO:0080144
name: intracellular amino acid homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell." [PMID:19955263]
synonym: "amino acid homeostasis" BROAD []
synonym: "cellular amino acid homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0080145
name: intracellular cysteine homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of cysteine within a cell." [PMID:19955263]
synonym: "cellular cysteine homeostasis" EXACT []
synonym: "cysteine homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0080146
name: L-cysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+." [MetaCyc:LCYSDESULF-RXN, PMID:19955263]
xref: MetaCyc:LCYSDESULF-RXN
xref: Reactome:R-HSA-1614591 "Excess cysteine yields lanthionine and H2S"
xref: Reactome:R-HSA-1614614 "Cysteine is degraded to serine and H2S"
xref: RHEA:24931
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0080147
name: root hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state." [PMID:19675148]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048765 ! root hair cell differentiation

[Term]
id: GO:0080148
name: negative regulation of response to water deprivation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [PMID:18835996]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2000070 ! regulation of response to water deprivation
relationship: negatively_regulates GO:0009414 ! response to water deprivation

[Term]
id: GO:0080149
name: sucrose induced translational repression
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level." [PMID:19403731]
synonym: "negative regulation of translation in response to sucrose" EXACT []
is_a: GO:0032055 ! negative regulation of translation in response to stress

[Term]
id: GO:0080150
name: S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine." [MetaCyc:RXN-6722, PMID:10852939]
synonym: "S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity" EXACT []
xref: MetaCyc:RXN-6722
xref: RHEA:36099
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080151
name: positive regulation of salicylic acid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction." [PMID:20181750]
synonym: "positive regulation of salicylic acid mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway
relationship: positively_regulates GO:0009863 ! salicylic acid mediated signaling pathway

[Term]
id: GO:0080152
name: regulation of reductive pentose-phosphate cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle." [PMID:17031544]
synonym: "regulation of C3 photosynthesis" NARROW []
synonym: "regulation of Calvin cycle" NARROW []
is_a: GO:0010110 ! regulation of photosynthesis, dark reaction
relationship: regulates GO:0019253 ! reductive pentose-phosphate cycle

[Term]
id: GO:0080153
name: negative regulation of reductive pentose-phosphate cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle." [PMID:17031544, PMID:20399532]
synonym: "negative regulation of C3 photosynthesis" NARROW []
synonym: "negative regulation of Calvin cycle" NARROW []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0080152 ! regulation of reductive pentose-phosphate cycle
is_a: GO:1905156 ! negative regulation of photosynthesis
relationship: negatively_regulates GO:0019253 ! reductive pentose-phosphate cycle

[Term]
id: GO:0080154
name: regulation of fertilization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994]
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0009566 ! fertilization

[Term]
id: GO:0080155
name: regulation of double fertilization forming a zygote and endosperm
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:DHL, PMID:20478994]
is_a: GO:0080154 ! regulation of fertilization
relationship: regulates GO:0009567 ! double fertilization forming a zygote and endosperm

[Term]
id: GO:0080156
name: mitochondrial mRNA modification
namespace: biological_process
def: "The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [PMID:20566637]
synonym: "mitochondrial mRNA editing" NARROW []
synonym: "mitochondrial RNA editing" BROAD []
is_a: GO:0016556 ! mRNA modification
is_a: GO:1900864 ! mitochondrial RNA modification

[Term]
id: GO:0080157
name: regulation of plant-type cell wall organization or biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [PMID:20530756]
synonym: "regulation of plant-type cell wall organisation or biogenesis" EXACT [GOC:mah]
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: regulates GO:0071669 ! plant-type cell wall organization or biogenesis

[Term]
id: GO:0080158
name: obsolete chloroplast ribulose bisphosphate carboxylase complex biogenesis
namespace: biological_process
def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a chloroplast ribulose bisphosphate carboxylase (RubisCO) complex. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex." [PMID:20561259]
comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation.
is_obsolete: true

[Term]
id: GO:0080159
name: zygote elongation
namespace: biological_process
def: "The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana." [GOC:tb]
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0080160
name: selenate transport
namespace: biological_process
def: "The directed movement of selenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18761637]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0080161
name: auxin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth." [PMID:19506555]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0080162
name: endoplasmic reticulum to cytosol auxin transport
namespace: biological_process
def: "The directed movement of auxins from endoplasmic reticulum to cytosol." [PMID:19506555]
synonym: "intracellular auxin transport" BROAD []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0060918 ! auxin transport

[Term]
id: GO:0080163
name: obsolete regulation of protein serine/threonine phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "regulation of protein phosphatase type 2c activity" NARROW []
is_obsolete: true

[Term]
id: GO:0080164
name: regulation of nitric oxide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:0080165
name: callose deposition in phloem sieve plate
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [PMID:19470642]
is_a: GO:0052545 ! callose localization

[Term]
id: GO:0080166
name: stomium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0080167
name: response to karrikin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants)." [PMID:20351290]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0080168
name: abscisic acid transport
namespace: biological_process
def: "The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:20133881]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0046865 ! terpenoid transport

[Term]
id: GO:0080169
name: cellular response to boron-containing substance deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances." [PMID:20059736]
synonym: "cellular response to boron deprivation" EXACT []
synonym: "cellular response to boron starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0062197 ! cellular response to chemical stress
is_a: GO:0080029 ! cellular response to boron-containing substance levels

[Term]
id: GO:0080170
name: hydrogen peroxide transmembrane transport
namespace: biological_process
def: "The process in which hydrogen peroxide is transported across a membrane." [GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "hydrogen peroxide membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0080171
name: lytic vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380]
synonym: "lytic vacuolar assembly" NARROW []
synonym: "lytic vacuole biogenesis" RELATED []
synonym: "lytic vacuole organisation" EXACT []
synonym: "lytic vacuole organization and biogenesis" RELATED []
is_a: GO:0007033 ! vacuole organization

[Term]
id: GO:0080172
name: petal epidermis patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis." [GOC:tb]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0080173
name: male-female gamete recognition during double fertilization forming a zygote and endosperm
namespace: biological_process
def: "The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana." [PMID:21123745]
synonym: "gamete recognition" BROAD []
synonym: "male-female gamete recognition" EXACT []
is_a: GO:0009988 ! cell-cell recognition
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0061936 ! fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm

[Term]
id: GO:0080175
name: phragmoplast microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells." [PMID:19383896]
synonym: "phragmoplast microtubule cytoskeleton organization" EXACT []
synonym: "phragmoplast microtubule organisation" EXACT [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0080176
name: xyloglucan 1,6-alpha-xylosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus." [PMID:20801759]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0080177
name: plastoglobule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [PMID:20813909]
synonym: "plastoglobule organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0009658 ! chloroplast organization

[Term]
id: GO:0080178
name: 5-carbamoylmethyl uridine residue modification
namespace: biological_process
def: "The chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA." [GOC:dph, GOC:tb]
synonym: "5-carbamoylmethyluridine metabolic process" RELATED []
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0080179
name: 1-methylguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-methylguanosine." [GOC:tb]
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0080180
name: 2-methylguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-methylguanosine." [GOC:tb]
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0080181
name: lateral root branching
namespace: biological_process
def: "Any process involved in the formation of branches in lateral roots." [GOC:tb]
is_a: GO:0001763 ! morphogenesis of a branching structure
relationship: part_of GO:0010102 ! lateral root morphogenesis

[Term]
id: GO:0080182
name: obsolete histone H3-K4 trimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone." [GOC:BHF, GOC:se, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0080183
name: response to photooxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [DOI:10.1111/j.1399-3054.1994.tb03042.x]
is_a: GO:0006979 ! response to oxidative stress

[Term]
id: GO:0080184
name: response to phenylpropanoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin." [GOC:tb]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0080185
name: effector-mediated activation of plant hypersensitive response by symbiont
namespace: biological_process
alt_id: GO:0052101
alt_id: GO:0052286
alt_id: GO:0052423
alt_id: GO:0052527
def: "A symbiont process in which a molecule secreted by the symbiont activates a resistance gene-dependent defense response signaling pathway in the plant host, in order to activate a hypersensitive response to induce necrosis. In the plant, this process involves the direct or indirect recognition of the symbiont effector protein for example through plant resistance receptor or R proteins (or R genes)." [PMID:16497589, PMID:22241993, PMID:23411798, PMID:27641772]
synonym: "activation by organism of defense response in host by specific elicitors" BROAD []
synonym: "activation by organism of host gene-for-gene resistance" EXACT []
synonym: "activation by organism of host resistance gene-dependent defense response" EXACT []
synonym: "activation by symbiont of host resistance gene-dependent defense response" EXACT []
synonym: "activation of HR" NARROW [GOC:pamgo_curators]
synonym: "activation of hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "avirulence protein" RELATED []
synonym: "effector-mediated induction of plant hypersensitive response by symbiont" EXACT []
synonym: "effector-triggered immunity" BROAD []
synonym: "effector-triggered induction of host innate immune response" RELATED []
synonym: "effector-triggered induction of plant hypersensitive response by symbiont" RELATED []
synonym: "effector-triggered necrosis" RELATED [PMID:27641772]
synonym: "ETI triggered of host innate immune response" RELATED []
synonym: "ETI-triggered of host innate immune response" RELATED []
synonym: "induction by organism of defense response in host by specific elicitors" BROAD []
synonym: "induction by organism of host gene-for-gene resistance" EXACT []
synonym: "induction by organism of pathogen-race/host plant cultivar-specific resistance in host" BROAD []
synonym: "induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD []
synonym: "induction by symbiont of host resistance gene-dependent defense response" EXACT []
synonym: "induction of effector-triggered immunity (ETI)" RELATED []
synonym: "necrotrophic effector" RELATED []
synonym: "positive regulation by organism of defense response in host by specific elicitors" BROAD []
synonym: "positive regulation by organism of host gene-for-gene resistance" EXACT []
synonym: "positive regulation by symbiont of host resistance gene-dependent defense response" RELATED []
synonym: "positive regulation by symbiont of plant HR" EXACT [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of plant hypersensitive response" EXACT [GOC:pamgo_curators]
xref: Wikipedia:Effector-triggered_immunity
is_a: GO:0034055 ! effector-mediated activation of host programmed cell death by symbiont
is_a: GO:0052158 ! symbiont-mediated perturbation of host resistance gene-dependent defense response

[Term]
id: GO:0080186
name: developmental vegetative growth
namespace: biological_process
def: "The increase in size or mass of non-reproductive plant parts." [PO:0007134]
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0080187
name: floral organ senescence
namespace: biological_process
def: "The last stage of flower development during which programmed degradation of macromolecules and nutrient recycling take place." [PMID:19380421, PMID:21689171]
comment: Includes senescence of petals, sepals, anthers, and any other plant organ that is part of a flower. Floral organ senescence may follow pollination. In some flowers, the organs of the corolla abscise before they senesce.
is_a: GO:0090693 ! plant organ senescence
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0080188
name: gene silencing by siRNA-directed DNA methylation
namespace: biological_process
def: "A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism." [PMID:21420348, PMID:33031395]
comment: This process has been shown in plants and in yeasts, but so far has not been detected in vertebrates, organisms that lack RNA-dependent RNA polymerase.
synonym: "gene silencing by RNA-directed DNA methylation" RELATED []
synonym: "RdDM" EXACT []
synonym: "RNA-directed DNA methylation" RELATED []
is_a: GO:0006346 ! DNA methylation-dependent constitutive heterochromatin formation
is_a: GO:0141194 ! siRNA-mediated heterochromatin formation

[Term]
id: GO:0080189
name: primary growth
namespace: biological_process
def: "Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed." [ISBN:0471245208]
comment: Has its inception in the apical meristems (PO:0020144) and continues in their derivative meristems - protoderm (PO:0006210) and procambium (PO:0025275) - even in older tissues. Primary and secondary growth can occur simultaneously in the same organism.
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0040007 ! growth

[Term]
id: GO:0080190
name: lateral growth
namespace: biological_process
def: "Growth of a plant axis (shoot axis or root) that originates from a lateral meristem." [PO:0020145]
comment: Includes thickening of plant axes (PO:0025004) due to the activity of a cambium (PO:0005597), known as secondary growth and found in most gymnosperms and dicotyledons, a primary thickening meristem (PO:0005039) as found in many monocotyledons, some ferns and some cycads, or secondary thickening meristem, (PO:0025414) as found in some monocotyledons.
is_a: GO:0040007 ! growth

[Term]
id: GO:0080191
name: secondary thickening
namespace: biological_process
def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem." [JSTOR:4354165, PO:0025004, PO:0025414]
comment: Occurs in shoot axes in some monocotyledons such as Dracaena, and rarely in roots of monocotyledons. Distinct from primary thickening, because it is distant from and generally discontinuous with the apical meristem.
is_a: GO:0080190 ! lateral growth

[Term]
id: GO:0080192
name: primary thickening
namespace: biological_process
def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem." [ISBN:0471245208, JSTOR:4354165, PO:0005039, PO:0025004]
comment: Occurs in shoot axes and rarely in roots in many monocotyledons.
is_a: GO:0080190 ! lateral growth

[Term]
id: GO:0080193
name: diffuse secondary thickening
namespace: biological_process
def: "Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem." [GOC:dhl]
comment: Occurs in the stems (PO:0009047) of some Arecaceae (palms).
is_a: GO:0080190 ! lateral growth

[Term]
id: GO:0085000
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type V secretion system
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type V secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085001
name: formation of stylet for nutrient acquisition
namespace: biological_process
def: "The assembly of a stylet, a hollow protrusible spear-like symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "formation by symbiont of stylet for nutrient acquisition from host" RELATED []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition

[Term]
id: GO:0085002
name: obsolete interaction with host mediated by secreted substance released by symbiont from symbiotic structure
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a symbiont secreted substance released by specialized structures generated in either organisms as a result of the symbiotic interaction. The term host is used for the larger (macro) of the two members of a symbiosis." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085003
name: obsolete interaction with host via secreted substance released from stylet
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the stylet, a hollow protrusible spear-like structure in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085004
name: obsolete interaction with host via secreted substance released from haustorium
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the haustorium, a projection from a cell or tissue that penetrates the host's cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085005
name: obsolete interaction with host via secreted substance released from invasive hyphae
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via invasive hyphae. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085006
name: obsolete interaction with host mediated by symbiont secreted substance released from symbiont-containing vacuole
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via a symbiont-containing vacuole, a specialized sac within the host in which the symbiont resides. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "interaction with host mediated by symbiont secreted substance released from parasitophorous vacuole" EXACT []
is_obsolete: true

[Term]
id: GO:0085007
name: obsolete interaction with host via secreted substance released from rhoptry
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the rhoptry, a large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was deprecated because it conflated the process in which a gene product is involved with the secreaton system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085008
name: obsolete interaction with host via secreted substance released from microneme
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the microneme, a small, elongated secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085009
name: obsolete interaction with host mediated by symbiont secreted substance released from Maurer's cleft
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via Maurer's cleft. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "interaction with host mediated by symbiont secreted substance released from Maurers cleft" EXACT []
is_obsolete: true

[Term]
id: GO:0085010
name: obsolete interaction with host mediated by secreted substance entering host via endocytosis
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a secreted substance from the symbiont entering host cells via endocytosis of the substance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085011
name: obsolete interaction with host via protein secreted by Sec complex
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Sec complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "interaction with host via protein secreted by Sec secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0085012
name: obsolete interaction with host via protein secreted by Tat complex
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Tat complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "interaction with host via protein secreted by Tat secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0085013
name: obsolete interaction with host via protein secreted by type VII secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type VII secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085014
name: dormancy entry of symbiont in host
namespace: biological_process
def: "Entry into a dormant state of the symbiont within the host organism." [GOC:jl]
is_a: GO:0022611 ! dormancy process
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0085015
name: dormancy maintenance of symbiont in host
namespace: biological_process
def: "Any process in which a dormant state is maintained by the symbiont within the host organism." [GOC:jl]
synonym: "non-replicating persistence" EXACT []
synonym: "NRP" EXACT []
is_a: GO:0022611 ! dormancy process
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0085016
name: dormancy exit of symbiont in host
namespace: biological_process
def: "Exit from dormant state, also known as resuscitation, of the symbiont within the host organism." [GOC:jl]
synonym: "resuscitation of symbiont" EXACT []
is_a: GO:0022611 ! dormancy process
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0085017
name: entry into host cell by a symbiont-containing vacuole
namespace: biological_process
alt_id: GO:0052370
def: "The invasion by a symbiont of a cell of a host organism, forming a vacuole in which the symbiont resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole." [GOC:jl, PMID:18665841, PMID:8690024, PMID:9580555]
synonym: "symbiont entry into host cell forming a parasitophorous vacuole" EXACT []
synonym: "symbiont entry into host cell forming a pathogen-containing vacuole" EXACT []
synonym: "symbiont entry into host cell forming a symbiont-containing vacuole" RELATED []
is_a: GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0085018
name: obsolete maintenance of symbiont-containing vacuole by host
namespace: biological_process
def: "OBSOLETE. The process in which a host organism maintains the structure and function of a symbiont-containing vacuole. The symbiont-containing vacuole is a membrane-bounded vacuole within a host cell in which a symbiont organism resides, and can serve to reduce pathogenicity of invading symbionts by restricting them to the vacuolar compartment." [GOC:jl, GOC:yaf, PMID:18665841]
comment: This term has been obsoleted because there is no evidence that this process exists.
synonym: "maintenance of parasitophorous vacuole" EXACT []
synonym: "maintenance of pathogen-containing vacuole" EXACT []
synonym: "maintenance of vacuolar integrity during bacterial infection" NARROW []
is_obsolete: true

[Term]
id: GO:0085019
name: formation of tubovesicular network for nutrient acquisition
namespace: biological_process
def: "The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "formation by symbiont of a tubovesicular network for nutrient acquisition from host" RELATED []
synonym: "formation of a symbiont- induced tubovesicular network for nutrient acquisition from host" EXACT []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition

[Term]
id: GO:0085020
name: protein K6-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]
synonym: "protein K6-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0085021
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type I secretion system
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type I secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085022
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type VI secretion system
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VI secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085023
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type VII secretion system
namespace: biological_process
def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VII secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
is_obsolete: true

[Term]
id: GO:0085024
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by Sec complex
namespace: biological_process
def: "OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Sec complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Sec secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0085025
name: obsolete modification by symbiont of host morphology or physiology via protein secreted by Tat complex
namespace: biological_process
def: "OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Tat complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target.
synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Tat secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0085026
name: tubovesicular membrane network
namespace: cellular_component
def: "A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains." [GOC:pamgo_curators]
synonym: "TVM network" EXACT []
synonym: "TVN" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0043264 ! extracellular membraneless organelle

[Term]
id: GO:0085029
name: extracellular matrix assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0085030
name: symbiotic process benefiting host
namespace: biological_process
def: "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism." [GOC:pdt]
synonym: "mutualism" RELATED []
is_a: GO:0044403 ! biological process involved in symbiotic interaction

[Term]
id: GO:0085032
name: symbiont-mediated perturbation of host NF-kappaB cascade
namespace: biological_process
def: "A process in which a symbiont alters or subverts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED []
synonym: "modulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT []
synonym: "perturbation of host canonical NF-kappaB cascade" RELATED []
synonym: "perturbation of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "symbiont-mediated perturbation of host canonical NF-kappaB cascade" RELATED []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0085033
name: symbiont-mediated activation of host NF-kappaB cascade
namespace: biological_process
def: "A process that initiates, promotes, or enhances a host NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11907233, PMID:17490702, PMID:21098302, PMID:21199955, PMID:31311877, PMID:7845680]
synonym: "activation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "induction by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "induction of host canonical NF-kappaB signal transduction" EXACT []
synonym: "induction of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "symbiont-mediated activation of host canonical NF-kappaB signal transduction" RELATED []
synonym: "symbiont-mediated activation of host NF-kappaB signal transduction" EXACT []
synonym: "up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
xref: VZ:841
is_a: GO:0052028 ! symbiont-mediated activation of host signal transduction pathway
is_a: GO:0085032 ! symbiont-mediated perturbation of host NF-kappaB cascade

[Term]
id: GO:0085034
name: symbiont-mediated suppression of host NF-kappaB cascade
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18250452, PMID:22442494, PMID:24648522, PMID:33567255]
synonym: "disruption of host canonical NF-kappaB cascade" RELATED []
synonym: "disruption of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "symbiont-mediated suppression of host canonical NF-kappaB cascade" RELATED []
xref: VZ:695
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway
is_a: GO:0085032 ! symbiont-mediated perturbation of host NF-kappaB cascade

[Term]
id: GO:0085035
name: haustorium
namespace: cellular_component
def: "A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane." [GOC:pamgo_curators]
comment: See also: extrahaustorial matrix ; GO:0085036 and extrahaustorial membrane ; GO:0085037.
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0085036
name: extrahaustorial matrix
namespace: cellular_component
def: "The space between the symbiont plasma membrane and the extrahaustorial membrane of the host." [GOC:pamgo_curators]
comment: See also: haustorium ; GO:0085035 and extrahaustorial membrane ; GO:0085037.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0043655 ! host extracellular space

[Term]
id: GO:0085037
name: extrahaustorial membrane
namespace: cellular_component
def: "The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane." [GOC:pamgo_curators]
comment: See also: haustorium ; GO:0085035 and extrahaustorial matrix ; GO:0085036.
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0020002 ! host cell plasma membrane

[Term]
id: GO:0085039
name: hyphal membrane
namespace: cellular_component
def: "A host-derived membrane surrounding the symbiont hypha during infection." [GOC:pamgo_curators]
synonym: "extra-invasive hyphal membrane" RELATED []
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0085040
name: obsolete extra-invasive hyphal space
namespace: cellular_component
def: "OBSOLETE. The space between the symbiont plasma membrane and the extra-invasive hyphal membrane." [GOC:pamgo_curators]
comment: This term was obsoleted because the cellular component represented is not different from 'host cytoplasm'.
is_obsolete: true

[Term]
id: GO:0085041
name: arbuscule
namespace: cellular_component
def: "Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange." [GOC:pamgo_curators]
comment: See also: periarbuscular membrane ; GO:0085042.
is_a: GO:0085035 ! haustorium

[Term]
id: GO:0085042
name: periarbuscular membrane
namespace: cellular_component
def: "A host-derived membrane surrounding the symbiont arbuscule during symbiosis." [GOC:pamgo_curators]
comment: See also: arbuscule ; GO:0085041.
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0085044
name: symbiont-mediated disruption of host cuticle
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
synonym: "catabolism of host cuticle" EXACT []
synonym: "degradation of host cuticle" RELATED []
synonym: "disassembly by symbiont of host cuticle" RELATED []
is_a: GO:0052111 ! symbiont-mediated disruption of host anatomical structure

[Term]
id: GO:0086001
name: cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0001508 ! action potential

[Term]
id: GO:0086002
name: cardiac muscle cell action potential involved in contraction
namespace: biological_process
def: "An action potential that occurs in a cardiac muscle cell and is involved in its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086003 ! cardiac muscle cell contraction

[Term]
id: GO:0086003
name: cardiac muscle cell contraction
namespace: biological_process
def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0086004
name: regulation of cardiac muscle cell contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0055117 ! regulation of cardiac muscle contraction
is_a: GO:1903115 ! regulation of actin filament-based movement
relationship: regulates GO:0086003 ! cardiac muscle cell contraction

[Term]
id: GO:0086005
name: ventricular cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction

[Term]
id: GO:0086006
name: voltage-gated sodium channel activity involved in cardiac muscle cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005248 ! voltage-gated sodium channel activity

[Term]
id: GO:0086007
name: voltage-gated calcium channel activity involved in cardiac muscle cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0086008
name: voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0086009
name: membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0086010
name: membrane depolarization during action potential
namespace: biological_process
def: "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0051899 ! membrane depolarization
relationship: part_of GO:0001508 ! action potential

[Term]
id: GO:0086011
name: membrane repolarization during action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086009 ! membrane repolarization
relationship: part_of GO:0001508 ! action potential

[Term]
id: GO:0086012
name: membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086010 ! membrane depolarization during action potential
relationship: part_of GO:0086001 ! cardiac muscle cell action potential

[Term]
id: GO:0086013
name: membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086011 ! membrane repolarization during action potential
is_a: GO:0099622 ! cardiac muscle cell membrane repolarization
relationship: part_of GO:0086001 ! cardiac muscle cell action potential

[Term]
id: GO:0086014
name: atrial cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in an atrial cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction
relationship: part_of GO:0086026 ! atrial cardiac muscle cell to AV node cell signaling

[Term]
id: GO:0086015
name: SA node cell action potential
namespace: biological_process
def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell action potential" EXACT []
synonym: "SAN cardiac muscle cell action potential" EXACT []
synonym: "sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086018 ! SA node cell to atrial cardiac muscle cell signaling

[Term]
id: GO:0086016
name: AV node cell action potential
namespace: biological_process
def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086027 ! AV node cell to bundle of His cell signaling

[Term]
id: GO:0086017
name: Purkinje myocyte action potential
namespace: biological_process
def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086029 ! Purkinje myocyte to ventricular cardiac muscle cell signaling

[Term]
id: GO:0086018
name: SA node cell to atrial cardiac muscle cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW []
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication

[Term]
id: GO:0086019
name: cell-cell signaling involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0086065 ! cell communication involved in cardiac conduction

[Term]
id: GO:0086020
name: gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling" EXACT []
synonym: "gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling" EXACT []
synonym: "gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling" EXACT []
synonym: "gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling" NARROW []
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling

[Term]
id: GO:0086021
name: SA node cell to atrial cardiac muscle cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" NARROW []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication

[Term]
id: GO:0086022
name: SA node cell-atrial cardiac muscle cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication" EXACT []
synonym: "SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT []
synonym: "SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT []
synonym: "sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT []
synonym: "sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" NARROW []
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086070 ! SA node cell to atrial cardiac muscle cell communication

[Term]
id: GO:0086023
name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "The series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "adrenergic receptor signaling pathway involved in heart process" EXACT []
synonym: "adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:bf]
is_a: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway
is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process

[Term]
id: GO:0086024
name: obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "OBSOLETE. An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118]
comment: This term was obsoleted because it represents a GO-CAM pathway.
synonym: "activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "adrenergic receptor signaling pathway involved in positive regulation of heart rate" BROAD []
synonym: "adrenergic receptor signalling pathway involved in positive regulation of heart rate" BROAD [GOC:bf]
synonym: "beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:mtg_cardiac_conduct_nov11]
synonym: "Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:mtg_cardiac_conduct_nov11]
synonym: "If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11]
is_obsolete: true
replaced_by: GO:0071880

[Term]
id: GO:0086026
name: atrial cardiac muscle cell to AV node cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte to atrioventricular node cell signaling" EXACT []
synonym: "atrial cardiomyocyte to AV node cell signaling" EXACT []
synonym: "atrial cardiomyocyte to AV node cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication

[Term]
id: GO:0086027
name: AV node cell to bundle of His cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node to bundle of His cell signaling" EXACT []
synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086067 ! AV node cell to bundle of His cell communication

[Term]
id: GO:0086028
name: bundle of His cell to Purkinje myocyte signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signaling" EXACT []
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication

[Term]
id: GO:0086029
name: Purkinje myocyte to ventricular cardiac muscle cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication

[Term]
id: GO:0086030
name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
namespace: biological_process
def: "An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541]
synonym: "adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT []
synonym: "adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "adrenergic receptor-induced cardiac relaxation" RELATED [PMID:10571541]
synonym: "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
relationship: part_of GO:0055119 ! relaxation of cardiac muscle

[Term]
id: GO:0086033
name: G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
namespace: biological_process
def: "A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT []
synonym: "M2 receptor signalling pathway involved in negative regulation of heart rate" EXACT []
synonym: "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT []
synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate" EXACT []
is_a: GO:0086093 ! G protein-coupled acetylcholine receptor signaling pathway involved in heart process
relationship: part_of GO:0003063 ! negative regulation of heart rate by acetylcholine

[Term]
id: GO:0086036
name: regulation of cardiac muscle cell membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0086037
name: P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005391 ! P-type sodium:potassium-exchanging transporter activity

[Term]
id: GO:0086038
name: calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005432 ! calcium:sodium antiporter activity

[Term]
id: GO:0086039
name: P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential" EXACT []
is_a: GO:0005388 ! P-type calcium transporter activity

[Term]
id: GO:0086040
name: sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential" EXACT []
is_a: GO:0015385 ! sodium:proton antiporter activity

[Term]
id: GO:0086041
name: voltage-gated potassium channel activity involved in SA node cell action potential depolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in SAN cell action potential depolarization" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential depolarization" NARROW []
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0086042
name: cardiac muscle cell-cardiac muscle cell adhesion
namespace: biological_process
def: "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cardiomyocyte-cardiomyocyte adhesion" EXACT []
is_a: GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0086043
name: bundle of His cell action potential
namespace: biological_process
def: "An action potential that occurs in a bundle of His cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086028 ! bundle of His cell to Purkinje myocyte signaling

[Term]
id: GO:0086044
name: atrial cardiac muscle cell to AV node cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling" EXACT []
synonym: "atrial cardiomyocyte to AV node cell communication by electrical coupling" EXACT []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication

[Term]
id: GO:0086045
name: membrane depolarization during AV node cell action potential
namespace: biological_process
def: "The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization during AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086016 ! AV node cell action potential

[Term]
id: GO:0086046
name: membrane depolarization during SA node cell action potential
namespace: biological_process
def: "The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane depolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086015 ! SA node cell action potential

[Term]
id: GO:0086047
name: membrane depolarization during Purkinje myocyte cell action potential
namespace: biological_process
def: "The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086017 ! Purkinje myocyte action potential

[Term]
id: GO:0086048
name: membrane depolarization during bundle of His cell action potential
namespace: biological_process
def: "The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane depolarization during bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086043 ! bundle of His cell action potential

[Term]
id: GO:0086049
name: membrane repolarization during AV node cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: part_of GO:0086016 ! AV node cell action potential

[Term]
id: GO:0086050
name: membrane repolarization during bundle of His cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane repolarization during bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: part_of GO:0086043 ! bundle of His cell action potential

[Term]
id: GO:0086051
name: membrane repolarization during Purkinje myocyte action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: part_of GO:0086017 ! Purkinje myocyte action potential

[Term]
id: GO:0086052
name: membrane repolarization during SA node cell action potential
namespace: biological_process
def: "The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane repolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: part_of GO:0086015 ! SA node cell action potential

[Term]
id: GO:0086053
name: AV node cell to bundle of His cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell to bundle of His cell communication by electrical coupling" EXACT []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086067 ! AV node cell to bundle of His cell communication

[Term]
id: GO:0086054
name: bundle of His cell to Purkinje myocyte communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication by electrical coupling" EXACT []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication

[Term]
id: GO:0086055
name: Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication

[Term]
id: GO:0086056
name: voltage-gated calcium channel activity involved in AV node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086057
name: voltage-gated calcium channel activity involved in bundle of His cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086058
name: voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086059
name: voltage-gated calcium channel activity involved SA node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086060
name: voltage-gated sodium channel activity involved in AV node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086061
name: voltage-gated sodium channel activity involved in bundle of His cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086062
name: voltage-gated sodium channel activity involved in Purkinje myocyte action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086063
name: voltage-gated sodium channel activity involved in SA node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential

[Term]
id: GO:0086064
name: cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0010644 ! cell communication by electrical coupling
is_a: GO:0086065 ! cell communication involved in cardiac conduction

[Term]
id: GO:0086065
name: cell communication involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0061337 ! cardiac conduction

[Term]
id: GO:0086066
name: atrial cardiac muscle cell to AV node cell communication
namespace: biological_process
def: "The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte to atrioventricular node cell communication" EXACT []
synonym: "atrial cardiomyocyte to AV node cell communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction

[Term]
id: GO:0086067
name: AV node cell to bundle of His cell communication
namespace: biological_process
def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell to bundle of His cell communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction

[Term]
id: GO:0086068
name: Purkinje myocyte to ventricular cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086065 ! cell communication involved in cardiac conduction

[Term]
id: GO:0086069
name: bundle of His cell to Purkinje myocyte communication
namespace: biological_process
def: "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular junction myocyte to bundle branch myocyte" NARROW []
synonym: "bundle branch myocyte to Purkinje myocyte communication" NARROW []
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication" EXACT []
synonym: "bundle of His myocyte to atrioventricular junction myocyte" NARROW []
synonym: "ventricular conduction system cell to cell communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction

[Term]
id: GO:0086070
name: SA node cell to atrial cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW []
is_a: GO:0086065 ! cell communication involved in cardiac conduction

[Term]
id: GO:0086071
name: atrial cardiac muscle cell-AV node cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication" EXACT []
synonym: "atrial cardiomyocyte-AV node cell adhesion involved in cell communication" EXACT []
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086066 ! atrial cardiac muscle cell to AV node cell communication

[Term]
id: GO:0086072
name: AV node cell-bundle of His cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell-bundle of His cell adhesion involved in cell communication" EXACT []
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086067 ! AV node cell to bundle of His cell communication

[Term]
id: GO:0086073
name: bundle of His cell-Purkinje myocyte adhesion involved in cell communication
namespace: biological_process
def: "The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086069 ! bundle of His cell to Purkinje myocyte communication

[Term]
id: GO:0086074
name: Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication

[Term]
id: GO:0086075
name: gap junction channel activity involved in cardiac conduction electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:1903763 ! gap junction channel activity involved in cell communication by electrical coupling

[Term]
id: GO:0086076
name: gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling" EXACT []
synonym: "gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling" RELATED []
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling

[Term]
id: GO:0086077
name: gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling" EXACT []
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling

[Term]
id: GO:0086078
name: gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling

[Term]
id: GO:0086079
name: gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling

[Term]
id: GO:0086080
name: protein binding involved in heterotypic cell-cell adhesion
namespace: molecular_function
def: "Binding to a protein or protein complex contributing to the adhesion of two different types of cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098632 ! cell-cell adhesion mediator activity

[Term]
id: GO:0086081
name: cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication
namespace: molecular_function
def: "Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication" EXACT []
synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication" EXACT []
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion

[Term]
id: GO:0086082
name: cell adhesive protein binding involved in AV node cell-bundle of His cell communication
namespace: molecular_function
def: "Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication" EXACT []
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion

[Term]
id: GO:0086083
name: cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
namespace: molecular_function
def: "Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion

[Term]
id: GO:0086084
name: cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication
namespace: molecular_function
def: "Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion

[Term]
id: GO:0086085
name: cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication
namespace: molecular_function
def: "Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication" EXACT []
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion

[Term]
id: GO:0086086
name: voltage-gated potassium channel activity involved in AV node cell action potential repolarization
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization" EXACT []
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

[Term]
id: GO:0086087
name: voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

[Term]
id: GO:0086088
name: voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

[Term]
id: GO:0086089
name: voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT []
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

[Term]
id: GO:0086090
name: voltage-gated potassium channel activity involved in SA node cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in SAN cell action potential" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential" NARROW []
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

[Term]
id: GO:0086091
name: regulation of heart rate by cardiac conduction
namespace: biological_process
def: "A cardiac conduction process that modulates the frequency or rate of heart contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0061337 ! cardiac conduction

[Term]
id: GO:0086092
name: regulation of the force of heart contraction by cardiac conduction
namespace: biological_process
def: "A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0002026 ! regulation of the force of heart contraction
is_a: GO:0061337 ! cardiac conduction

[Term]
id: GO:0086093
name: G protein-coupled acetylcholine receptor signaling pathway involved in heart process
namespace: biological_process
def: "A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in heart process" EXACT []
synonym: "G-protein coupled acetylcholine receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "M2 receptor signaling pathway involved in heart process" NARROW [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signaling pathway involved in heart process" RELATED [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway
is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process

[Term]
id: GO:0086094
name: obsolete positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
namespace: biological_process
def: "OBSOLETE. An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation" NARROW [PMID:21099118]
is_obsolete: true

[Term]
id: GO:0086095
name: obsolete positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
namespace: biological_process
def: "OBSOLETE. A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel]
comment: This term was obsoleted because it represents a molecular function.
synonym: "cardiac muscarinic receptor signaling via Gbeta/gamma" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signaling pathway involved in activation of IKACH" EXACT [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signaling pathway involved in ion channel activation" BROAD [GOC:mtg_cardiac_conduct_nov11]
synonym: "positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling" EXACT []
is_obsolete: true

[Term]
id: GO:0086096
name: obsolete adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. An adenylate cyclase-inhibiting adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541]
comment: This term was obsoleted because it represents a GO-CAM pathway.
synonym: "cardiac adrenergic receptor signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:bf]
synonym: "G-inhibitory-coupled Beta2AR signaling pathway involved in heart process" EXACT [PMID:17376402]
synonym: "Gi-coupled adrenergic receptor signaling pathway involved in heart process" EXACT [PMID:10571541]
synonym: "Gi-coupled Beta2-AR signaling pathway involved in heart process" EXACT [PMID:10571541]
is_obsolete: true
replaced_by: GO:0071880

[Term]
id: GO:0086097
name: phospholipase C-activating angiotensin-activated signaling pathway
namespace: biological_process
def: "A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "angiotensin-mediated signaling pathway via activation of phospholipase C" EXACT [GOC:bf]
synonym: "Gq-coupled angiotensin receptor signaling pathway" EXACT [GOC:bf]
synonym: "phospholipase C-activating angiotensin receptor signaling pathway" EXACT [GOC:bf]
synonym: "phospholipase C-activating angiotensin-mediated signaling pathway" RELATED []
synonym: "PLC-activating angiotensin receptor signaling pathway" EXACT [GOC:bf]
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0038166 ! angiotensin-activated signaling pathway

[Term]
id: GO:0086098
name: angiotensin-activated signaling pathway involved in heart process
namespace: biological_process
def: "An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf]
synonym: "angiotensin receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "angiotensin-mediated signaling pathway involved in heart process" RELATED []
is_a: GO:0038166 ! angiotensin-activated signaling pathway
is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process

[Term]
id: GO:0086099
name: phospholipase C-activating angiotensin-activated signaling pathway involved in heart process
namespace: biological_process
def: "An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process" EXACT [GOC:bf]
synonym: "cardiac angiotensin receptor signaling pathway via activation of PLC" EXACT [GOC:bf]
synonym: "Gq-coupled angiotensin receptor signaling pathway involved in heart process" EXACT [PMID:17376402]
synonym: "phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process" RELATED []
synonym: "PLC-activating angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf]
is_a: GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway
is_a: GO:0086098 ! angiotensin-activated signaling pathway involved in heart process

[Term]
id: GO:0086100
name: endothelin receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10977869]
synonym: "endothelin signaling pathway" RELATED [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0086101
name: endothelin receptor signaling pathway involved in heart process
namespace: biological_process
def: "An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "endothelin receptor signalling pathway involved in heart process" EXACT [GOC:bf]
is_a: GO:0086100 ! endothelin receptor signaling pathway
is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process

[Term]
id: GO:0086102
name: obsolete adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
namespace: biological_process
def: "OBSOLETE. An adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
comment: This term was obsoleted because it represents a GO-CAM pathway.
synonym: "AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:bf]
synonym: "adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT []
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity" EXACT [GOC:bf]
synonym: "Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" BROAD [GOC:bf]
synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current" EXACT [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel" EXACT [GOC:mtg_cardiac_conduct_nov11]
is_obsolete: true
replaced_by: GO:0031635

[Term]
id: GO:0086103
name: G protein-coupled receptor signaling pathway involved in heart process
namespace: biological_process
def: "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "G-protein coupled receptor signaling pathway involved in heart process" EXACT [GOC:bf]
synonym: "G-protein coupled receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "GPCR signaling pathway involved in cardiac process" EXACT [GOC:bf]
synonym: "GPCR signaling pathway involved in heart process" EXACT [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
relationship: part_of GO:0003015 ! heart process

[Term]
id: GO:0089700
name: obsolete protein kinase D signaling
namespace: biological_process
def: "OBSOLETE. A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dos, GOC:mah]
comment: This term was obsoleted because protein kinase D activity is part of other signaling pathways, it is not itself a signaling pathway.
synonym: "PKD signal transduction" EXACT [GOC:signaling]
synonym: "PKD signaling cascade" RELATED [GOC:mah]
synonym: "protein kinase D signal transduction" EXACT [GOC:signaling]
synonym: "protein kinase D signaling cascade" RELATED [GOC:signaling]
synonym: "protein kinase D signalling cascade" RELATED [GOC:mah]
is_obsolete: true

[Term]
id: GO:0089701
name: U2AF complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]
synonym: "U2 accessory factor" EXACT []
synonym: "U2AF" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0089702
name: undecaprenyl-phosphate glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP." [RHEA:28126]
xref: EC:2.7.8.31
xref: RHEA:28126
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0089703
name: L-aspartate transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0034487 ! vacuolar amino acid transmembrane transport
is_a: GO:0070778 ! L-aspartate transmembrane transport

[Term]
id: GO:0089704
name: L-glutamate transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole

[Term]
id: GO:0089705
name: protein localization to outer membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane." [GOC:dos, PMID:12823819]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0089706
name: L-ornithine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:1903352 ! L-ornithine transmembrane transport

[Term]
id: GO:0089707
name: L-lysine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-lysine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:1903401 ! L-lysine transmembrane transport

[Term]
id: GO:0089708
name: L-histidine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:0089709 ! L-histidine transmembrane transport
is_a: GO:1902024 ! L-histidine transport
is_a: GO:1990822 ! basic amino acid transmembrane transport

[Term]
id: GO:0089709
name: L-histidine transmembrane transport
namespace: biological_process
def: "The directed movement of L-histidine across a membrane." [PMID:21307582]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015801 ! aromatic amino acid transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0089710
name: endocytic targeting sequence binding
namespace: molecular_function
def: "Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits." [PMID:8918456]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0089713
name: Cbf1-Met4-Met28 complex
namespace: cellular_component
def: "A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation." [PMID:8665859, PMID:9171357]
is_a: GO:0005667 ! transcription regulator complex

[Term]
id: GO:0089714
name: UDP-N-acetyl-D-mannosamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+." [EC:1.1.1.336]
xref: EC:1.1.1.336
xref: RHEA:25780
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0089715
name: tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37." [PMID:25063302, RHEA:70027]
comment: This activity is distinct from tRNA (adenine(37)-C2-)-methyltransferase activity (GO:0002935) in that it requires the presence of a threonylcarbamoyl modification.
synonym: "tRNA (L-threonylcarbamoyladenosine(37)-C(2)) methyltransferase activity" EXACT []
synonym: "tRNA (L-threonylcarbamoyladenosine37-C2-) methyltransferase activity" EXACT []
synonym: "tRNA m6t6A37 methyltransferase activity" EXACT []
xref: MetaCyc:RXN0-7114
xref: RHEA:70027
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0089716
name: Pip2-Oaf1 complex
namespace: cellular_component
def: "A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins." [PMID:8972187, PMID:9288897]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0089717
name: obsolete spanning component of membrane
namespace: cellular_component
def: "OBSOLETE. The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0016020

[Term]
id: GO:0089718
name: amino acid import across plasma membrane
namespace: biological_process
alt_id: GO:0043092
alt_id: GO:0044745
alt_id: GO:1902837
def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
synonym: "amino acid import into cell" EXACT []
synonym: "amino acid transmembrane import" BROAD []
synonym: "L-amino acid import" BROAD []
synonym: "L-amino acid uptake" NARROW []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0089719
name: RHG protein domain binding
namespace: molecular_function
def: "Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)." [GOC:dos, GOC:ha]
synonym: "iap binding domain binding" EXACT []
synonym: "inhibitor of apoptosis binding domain binding" EXACT []
synonym: "reaper hid grim domain binding" EXACT []
synonym: "RHG domain binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0089720
name: caspase binding
namespace: molecular_function
def: "Binding to a caspase family protein." [GOC:dos, GOC:ha]
is_a: GO:0002020 ! protease binding

[Term]
id: GO:0089721
name: phosphoenolpyruvate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other." [GOC:dos]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity

[Term]
id: GO:0089722
name: phosphoenolpyruvate transmembrane transport
namespace: biological_process
def: "The directed movement of phosphoenolpytuvate across a membrane." [GOC:dos]
is_a: GO:0015714 ! phosphoenolpyruvate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0090001
name: replication fork arrest at tRNA locus
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit." [GOC:dph, GOC:tb]
is_a: GO:0043111 ! replication fork arrest

[Term]
id: GO:0090006
name: regulation of linear element assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060629 ! regulation of homologous chromosome segregation
relationship: regulates GO:0030999 ! linear element assembly

[Term]
id: GO:0090007
name: obsolete regulation of mitotic anaphase
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic anaphase, a cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:tb]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of mitotic anaphase" EXACT []
is_obsolete: true

[Term]
id: GO:0090008
name: hypoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0090009
name: primitive streak formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0090010
name: obsolete transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "TGFbeta signaling pathway involved in primitive streak formation" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0090011
name: obsolete Wnt signaling pathway involved in primitive streak formation
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "Wnt receptor signaling pathway involved in primitive streak formation" EXACT []
synonym: "Wnt receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in primitive streak formation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0016055
consider: GO:0090009

[Term]
id: GO:0090012
name: obsolete negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0090013
name: obsolete regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:0090014
name: leaflet formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0090015
name: positive regulation of leaflet formation by auxin mediated signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "positive regulation of leaflet formation by auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009734 ! auxin-activated signaling pathway
is_a: GO:0090016 ! regulation of leaflet formation
is_a: GO:1905623 ! positive regulation of leaf development
relationship: positively_regulates GO:0090014 ! leaflet formation

[Term]
id: GO:0090016
name: regulation of leaflet formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaflet formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:1901371 ! regulation of leaf morphogenesis
relationship: regulates GO:0090014 ! leaflet formation

[Term]
id: GO:0090017
name: anterior neural plate formation
namespace: biological_process
def: "The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021990 ! neural plate formation

[Term]
id: GO:0090018
name: posterior neural plate formation
namespace: biological_process
def: "The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021990 ! neural plate formation

[Term]
id: GO:0090019
name: obsolete regulation of transcription involved in anterior neural plate formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the anterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0090017

[Term]
id: GO:0090020
name: obsolete regulation of transcription involved in posterior neural plate formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the posterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0090018

[Term]
id: GO:0090021
name: obsolete positive regulation of posterior neural plate formation by Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of posterior neural plate formation by Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of posterior neural plate formation by Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of posterior neural plate formation by Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0016055
consider: GO:0021990

[Term]
id: GO:0090022
name: regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:1902622 ! regulation of neutrophil migration
relationship: regulates GO:0030593 ! neutrophil chemotaxis

[Term]
id: GO:0090023
name: positive regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis
is_a: GO:0090022 ! regulation of neutrophil chemotaxis
is_a: GO:1902624 ! positive regulation of neutrophil migration
relationship: positively_regulates GO:0030593 ! neutrophil chemotaxis

[Term]
id: GO:0090024
name: negative regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis
is_a: GO:0090022 ! regulation of neutrophil chemotaxis
is_a: GO:1902623 ! negative regulation of neutrophil migration
relationship: negatively_regulates GO:0030593 ! neutrophil chemotaxis

[Term]
id: GO:0090025
name: regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: regulates GO:0002548 ! monocyte chemotaxis

[Term]
id: GO:0090026
name: positive regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:0090025 ! regulation of monocyte chemotaxis
relationship: positively_regulates GO:0002548 ! monocyte chemotaxis

[Term]
id: GO:0090027
name: negative regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:0090025 ! regulation of monocyte chemotaxis
relationship: negatively_regulates GO:0002548 ! monocyte chemotaxis

[Term]
id: GO:0090028
name: positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
is_a: GO:0060239 ! positive regulation of signal transduction involved in conjugation with cellular fusion
relationship: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0090029
name: negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
is_a: GO:0060240 ! negative regulation of signal transduction involved in conjugation with cellular fusion
relationship: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0090030
name: regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process

[Term]
id: GO:0090031
name: positive regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process

[Term]
id: GO:0090032
name: negative regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process

[Term]
id: GO:0090033
name: positive regulation of filamentous growth
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb]
is_a: GO:0010570 ! regulation of filamentous growth
is_a: GO:0045927 ! positive regulation of growth
relationship: positively_regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0090034
name: regulation of chaperone-mediated protein complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0051131 ! chaperone-mediated protein complex assembly

[Term]
id: GO:0090035
name: positive regulation of chaperone-mediated protein complex assembly
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0090034 ! regulation of chaperone-mediated protein complex assembly
relationship: positively_regulates GO:0051131 ! chaperone-mediated protein complex assembly

[Term]
id: GO:0090036
name: regulation of protein kinase C signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
synonym: "regulation of protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of protein kinase C signalling cascade" RELATED [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0070528 ! protein kinase C signaling

[Term]
id: GO:0090037
name: positive regulation of protein kinase C signaling
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
synonym: "positive regulation of protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of protein kinase C signalling cascade" EXACT [GOC:mah]
is_a: GO:0090036 ! regulation of protein kinase C signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0070528 ! protein kinase C signaling

[Term]
id: GO:0090038
name: negative regulation of protein kinase C signaling
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
synonym: "negative regulation of protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of protein kinase C signalling cascade" RELATED [GOC:mah]
is_a: GO:0090036 ! regulation of protein kinase C signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0070528 ! protein kinase C signaling

[Term]
id: GO:0090042
name: tubulin deacetylation
namespace: biological_process
def: "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0006476 ! protein deacetylation

[Term]
id: GO:0090043
name: regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0090311 ! regulation of protein deacetylation
relationship: regulates GO:0090042 ! tubulin deacetylation

[Term]
id: GO:0090044
name: positive regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0090043 ! regulation of tubulin deacetylation
is_a: GO:0090312 ! positive regulation of protein deacetylation
relationship: positively_regulates GO:0090042 ! tubulin deacetylation

[Term]
id: GO:0090045
name: positive regulation of deacetylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0150065 ! regulation of deacetylase activity

[Term]
id: GO:0090046
name: obsolete regulation of transcription regulator activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term.
synonym: "regulation of transcription regulator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0090047
name: obsolete positive regulation of transcription regulator activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term.
synonym: "positive regulation of transcription regulator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0090048
name: obsolete negative regulation of transcription regulator activity
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term.
synonym: "negative regulation of transcription regulator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0090049
name: regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
relationship: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis

[Term]
id: GO:0090050
name: positive regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043536 ! positive regulation of blood vessel endothelial cell migration
is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis
relationship: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis

[Term]
id: GO:0090051
name: negative regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043537 ! negative regulation of blood vessel endothelial cell migration
is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis
relationship: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis

[Term]
id: GO:0090052
name: regulation of pericentric heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heterochromatin formation at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb]
synonym: "regulation of chromatin silencing at centromere" EXACT []
synonym: "regulation of pericentric heterochromatin assembly" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin formation
relationship: regulates GO:0031508 ! pericentric heterochromatin formation

[Term]
id: GO:0090053
name: positive regulation of pericentric heterochromatin formation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of pericentric heterochromatin formation." [GOC:dph, GOC:tb]
synonym: "positive regulation of chromatin silencing at centromere" EXACT []
synonym: "positive regulation of pericentric heterochromatin assembly" EXACT []
is_a: GO:0031453 ! positive regulation of heterochromatin formation
is_a: GO:0090052 ! regulation of pericentric heterochromatin formation
relationship: positively_regulates GO:0031508 ! pericentric heterochromatin formation

[Term]
id: GO:0090054
name: regulation of silent mating-type cassette heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette." [GOC:dph, GOC:tb]
synonym: "regulation of chromatin silencing at silent mating-type cassette" EXACT []
synonym: "regulation of silent mating-type cassette heterochromatin assembly" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin formation
relationship: regulates GO:0030466 ! silent mating-type cassette heterochromatin formation

[Term]
id: GO:0090055
name: positive regulation of silent mating-type cassette heterochromatin formation
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette." [GOC:dph, GOC:tb]
synonym: "positive regulation of chromatin silencing at silent mating-type cassette" EXACT []
synonym: "positive regulation of silent mating-type cassette heterochromatin assembly" EXACT []
is_a: GO:0031453 ! positive regulation of heterochromatin formation
is_a: GO:0090054 ! regulation of silent mating-type cassette heterochromatin formation
relationship: positively_regulates GO:0030466 ! silent mating-type cassette heterochromatin formation

[Term]
id: GO:0090056
name: regulation of chlorophyll metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb]
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
relationship: regulates GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0090057
name: root radial pattern formation
namespace: biological_process
def: "The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009956 ! radial pattern formation
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0090058
name: metaxylem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010089 ! xylem development

[Term]
id: GO:0090059
name: protoxylem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010089 ! xylem development

[Term]
id: GO:0090060
name: regulation of metaxylem development
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0090058 ! metaxylem development

[Term]
id: GO:0090062
name: regulation of trehalose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:dph, GOC:tb]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
relationship: regulates GO:0005991 ! trehalose metabolic process

[Term]
id: GO:0090063
name: positive regulation of microtubule nucleation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031116 ! positive regulation of microtubule polymerization
relationship: positively_regulates GO:0007020 ! microtubule nucleation

[Term]
id: GO:0090064
name: activation of microtubule nucleation
namespace: biological_process
def: "Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0090063 ! positive regulation of microtubule nucleation

[Term]
id: GO:0090066
name: regulation of anatomical structure size
namespace: biological_process
def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0090067
name: regulation of thalamus size
namespace: biological_process
def: "Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus." [GOC:dph, GOC:tb]
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0090068
name: positive regulation of cell cycle process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045787 ! positive regulation of cell cycle
relationship: positively_regulates GO:0022402 ! cell cycle process

[Term]
id: GO:0090069
name: regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0090070
name: positive regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0090069 ! regulation of ribosome biogenesis
relationship: positively_regulates GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0090071
name: negative regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0090069 ! regulation of ribosome biogenesis
relationship: negatively_regulates GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0090072
name: obsolete positive regulation of sodium ion transport via voltage-gated sodium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of sodium ions via the activity of voltage-gated sodium channels." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "positive regulation of sodium ion transport via voltage-gated sodium channel activity" EXACT []
is_obsolete: true
consider: GO:0005248

[Term]
id: GO:0090073
name: obsolete positive regulation of protein homodimerization activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090074
name: negative regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0043496 ! regulation of protein homodimerization activity

[Term]
id: GO:0090075
name: relaxation of muscle
namespace: biological_process
def: "A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain." [GOC:BHF, GOC:rl, PMID:19996365]
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0090076
name: relaxation of skeletal muscle
namespace: biological_process
def: "A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases." [GOC:BHF, GOC:rl]
is_a: GO:0090075 ! relaxation of muscle

[Term]
id: GO:0090077
name: foam cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0090078
name: smooth muscle derived foam cell differentiation
namespace: biological_process
def: "The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0090077 ! foam cell differentiation

[Term]
id: GO:0090079
name: translation regulator activity, nucleic acid binding
namespace: molecular_function
def: "Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0003676 ! nucleic acid binding
is_a: GO:0045182 ! translation regulator activity

[Term]
id: GO:0090080
name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade." [GOC:dph, GOC:tb]
synonym: "positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0043410 ! positive regulation of MAPK cascade

[Term]
id: GO:0090081
name: obsolete regulation of heart induction by regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of heart induction by regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of heart induction by regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of heart induction by regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060828
consider: GO:0090381

[Term]
id: GO:0090082
name: obsolete positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart, PMID:16860783]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of heart induction by negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0090090
consider: GO:1901321

[Term]
id: GO:0090083
name: regulation of inclusion body assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0070841 ! inclusion body assembly

[Term]
id: GO:0090084
name: negative regulation of inclusion body assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0090083 ! regulation of inclusion body assembly
relationship: negatively_regulates GO:0070841 ! inclusion body assembly

[Term]
id: GO:0090085
name: regulation of protein deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: regulates GO:0016579 ! protein deubiquitination

[Term]
id: GO:0090086
name: negative regulation of protein deubiquitination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0090085 ! regulation of protein deubiquitination
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
relationship: negatively_regulates GO:0016579 ! protein deubiquitination

[Term]
id: GO:0090087
name: regulation of peptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015833 ! peptide transport

[Term]
id: GO:0090088
name: regulation of oligopeptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:dph, GOC:tb]
is_a: GO:0090087 ! regulation of peptide transport
relationship: regulates GO:0006857 ! oligopeptide transport

[Term]
id: GO:0090089
name: regulation of dipeptide transport
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0090088 ! regulation of oligopeptide transport
relationship: regulates GO:0042938 ! dipeptide transport

[Term]
id: GO:0090090
name: negative regulation of canonical Wnt signaling pathway
namespace: biological_process
alt_id: GO:0035414
def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]
synonym: "negative regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "negative regulation of catenin import into nucleus" NARROW []
synonym: "negative regulation of catenin protein nuclear translocation" NARROW [GOC:mah]
synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
relationship: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway

[Term]
id: GO:0090091
name: positive regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
relationship: positively_regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0090092
name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
synonym: "regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007178 ! cell surface receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0090093
name: regulation of fungal-type cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:dph, GOC:tb]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
relationship: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process

[Term]
id: GO:0090094
name: metanephric cap mesenchymal cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf, PMID:19161241]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072186 ! metanephric cap morphogenesis

[Term]
id: GO:0090095
name: regulation of metanephric cap mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
relationship: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development

[Term]
id: GO:0090096
name: positive regulation of metanephric cap mesenchymal cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0090095 ! regulation of metanephric cap mesenchymal cell proliferation
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development
relationship: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development

[Term]
id: GO:0090100
name: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
synonym: "positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0007178 ! cell surface receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0090101
name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
synonym: "negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0007178 ! cell surface receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0090102
name: cochlea development
namespace: biological_process
def: "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound." [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0090103
name: cochlea morphogenesis
namespace: biological_process
def: "The process in which the cochlea is generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0090102 ! cochlea development

[Term]
id: GO:0090104
name: pancreatic epsilon cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin." [GOC:dph, GOC:tb]
synonym: "pancreatic E cell differentiation" EXACT []
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0090105
name: pancreatic E cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure." [GOC:dph, GOC:tb]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation

[Term]
id: GO:0090106
name: pancreatic E cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell." [GOC:dph, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation

[Term]
id: GO:0090107
name: regulation of high-density lipoprotein particle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0034380 ! high-density lipoprotein particle assembly

[Term]
id: GO:0090108
name: positive regulation of high-density lipoprotein particle assembly
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090107 ! regulation of high-density lipoprotein particle assembly
relationship: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly

[Term]
id: GO:0090109
name: regulation of cell-substrate junction assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb]
is_a: GO:0150116 ! regulation of cell-substrate junction organization
is_a: GO:1901888 ! regulation of cell junction assembly
relationship: regulates GO:0007044 ! cell-substrate junction assembly

[Term]
id: GO:0090110
name: COPII-coated vesicle cargo loading
namespace: biological_process
def: "The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]
synonym: "cargo loading into COPII vesicle" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cargo loading into COPII-coated vesicle" EXACT []
synonym: "cargo selection into COPII-coated vesicle" EXACT [GOC:vw]
synonym: "COPII coat-cargo complex assembly" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0035459 ! vesicle cargo loading
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0090114 ! COPII-coated vesicle budding

[Term]
id: GO:0090111
name: regulation of COPII vesicle uncoating
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:1901879 ! regulation of protein depolymerization
relationship: regulates GO:0090112 ! COPII vesicle uncoating

[Term]
id: GO:0090112
name: COPII vesicle uncoating
namespace: biological_process
def: "The process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0072319 ! vesicle uncoating
relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport

[Term]
id: GO:0090113
name: obsolete regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
namespace: biological_process
def: "OBSOLETE. The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function and a biological process.
is_obsolete: true

[Term]
id: GO:0090114
name: COPII-coated vesicle budding
namespace: biological_process
def: "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII vesicle budding" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
synonym: "ER exit" NARROW [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
synonym: "ER vesicle budding" BROAD [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0006900 ! vesicle budding from membrane
relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport

[Term]
id: GO:0090115
name: obsolete C-5 methylation on cytosine involved in chromatin silencing
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule that contributes to chromatin silencing." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090116
name: obsolete C-5 methylation of cytosine
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0003886
consider: GO:0009307

[Term]
id: GO:0090117
name: endosome to lysosome transport of low-density lipoprotein particle
namespace: biological_process
def: "The directed movement of low-density lipoprotein particle from endosomes to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "endosome to lysosome transport of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008333 ! endosome to lysosome transport
is_a: GO:0090119 ! vesicle-mediated cholesterol transport

[Term]
id: GO:0090118
name: receptor-mediated endocytosis involved in cholesterol transport
namespace: biological_process
def: "A receptor-mediated endocytosis process involved in intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:pr, GOC:tb]
synonym: "receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED []
synonym: "receptor-mediated endocytosis of LDL" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:dph]
synonym: "receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED []
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0090119
name: vesicle-mediated cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0090120
name: lysosome to ER cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum." [GOC:mah]
synonym: "lysosome to endoplasmic reticulum cholesterol transport" EXACT [GOC:mah]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0090121
name: low-density lipoprotein particle disassembly involved in cholesterol transport
namespace: biological_process
def: "The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090495 ! low-density lipoprotein particle disassembly
relationship: part_of GO:0030301 ! cholesterol transport

[Term]
id: GO:0090122
name: cholesterol ester hydrolysis involved in cholesterol transport
namespace: biological_process
def: "The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008203 ! cholesterol metabolic process
relationship: part_of GO:0090119 ! vesicle-mediated cholesterol transport

[Term]
id: GO:0090123
name: lysosomal glycocalyx
namespace: cellular_component
def: "The polysaccharide-based coating on the inner side of a lysosomal membrane. It may be involved in protecting the membrane from digestion by lysosomal enzymes." [GOC:ascb_2009, GOC:dph, GOC:krc, GOC:tb, PMID:10521503, PMID:22809326, PMID:29367433]
is_a: GO:0030112 ! glycocalyx
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0090124
name: obsolete N-4 methylation of cytosine
namespace: biological_process
def: "OBSOLETE. The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0009307
consider: GO:0015667

[Term]
id: GO:0090125
name: cell-cell adhesion involved in synapse maturation
namespace: biological_process
def: "The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "trans-synaptic adhesion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0060074 ! synapse maturation

[Term]
id: GO:0090126
name: protein-containing complex assembly involved in synapse maturation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "protein complex assembly involved in synapse maturation" RELATED []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0060074 ! synapse maturation

[Term]
id: GO:0090127
name: positive regulation of synapse maturation by synaptic transmission
namespace: biological_process
def: "Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007268 ! chemical synaptic transmission
is_a: GO:0090129 ! positive regulation of synapse maturation

[Term]
id: GO:0090128
name: regulation of synapse maturation
namespace: biological_process
def: "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
subset: goslim_synapse
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0060074 ! synapse maturation

[Term]
id: GO:0090129
name: positive regulation of synapse maturation
namespace: biological_process
def: "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090128 ! regulation of synapse maturation
relationship: positively_regulates GO:0060074 ! synapse maturation

[Term]
id: GO:0090130
name: tissue migration
namespace: biological_process
def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0090131
name: mesenchyme migration
namespace: biological_process
def: "The process in which the population of cells that make up a mesenchyme undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration
relationship: part_of GO:0072132 ! mesenchyme morphogenesis

[Term]
id: GO:0090132
name: epithelium migration
namespace: biological_process
def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration

[Term]
id: GO:0090133
name: mesendoderm migration
namespace: biological_process
def: "The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090132 ! epithelium migration
relationship: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0048382 ! mesendoderm development

[Term]
id: GO:0090134
name: cell migration involved in mesendoderm migration
namespace: biological_process
def: "The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0090133 ! mesendoderm migration

[Term]
id: GO:0090135
name: actin filament branching
namespace: biological_process
def: "The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0090136
name: epithelial cell-cell adhesion
namespace: biological_process
def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0090137
name: epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090136 ! epithelial cell-cell adhesion
relationship: part_of GO:0090132 ! epithelium migration

[Term]
id: GO:0090138
name: regulation of actin cytoskeleton organization by cell-cell adhesion
namespace: biological_process
def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0090139
name: mitochondrial chromosome packaging
namespace: biological_process
def: "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mitochondrial DNA packaging" EXACT []
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0090140
name: regulation of mitochondrial fission
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090141
name: positive regulation of mitochondrial fission
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
relationship: positively_regulates GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090143
name: nucleoid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "nucleoid organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0090144
name: mitochondrial nucleoid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mitochondrial nucleoid organisation" EXACT [GOC:mah]
is_a: GO:0090143 ! nucleoid organization

[Term]
id: GO:0090145
name: obsolete mitochondrial nucleoid organization involved in mitochondrial fission
namespace: biological_process
def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid that contributes to mitochondrial division." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represented a phenotype.
synonym: "mitochondrial nucleoid organisation involved in mitochondrial fission" EXACT [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0000002
consider: GO:0000266

[Term]
id: GO:0090146
name: obsolete establishment of mitochondrion localization involved in mitochondrial fission
namespace: biological_process
def: "OBSOLETE. The directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represented a phenotype.
synonym: "establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah]
synonym: "mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0000002
consider: GO:0000266

[Term]
id: GO:0090147
name: obsolete regulation of establishment of mitochondrion localization involved in mitochondrial fission
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represented a phenotype.
synonym: "regulation of establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah]
synonym: "regulation of mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0000002
consider: GO:0000266

[Term]
id: GO:0090148
name: membrane fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "membrane scission" EXACT []
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0090149
name: mitochondrial membrane fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "membrane fission involved in mitochondrial fission" EXACT []
synonym: "mitochondrial membrane scission" EXACT []
is_a: GO:0090148 ! membrane fission
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090150
name: establishment of protein localization to membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in membrane" EXACT []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0072657 ! protein localization to membrane

[Term]
id: GO:0090151
name: establishment of protein localization to mitochondrial membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrial membrane" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0090152
name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrial membrane involved in mitochondrial fission" EXACT []
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090153
name: regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1905038 ! regulation of membrane lipid metabolic process
relationship: regulates GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0090154
name: positive regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
relationship: positively_regulates GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0090155
name: negative regulation of sphingolipid biosynthetic process
namespace: biological_process
alt_id: GO:0090157
def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis" RELATED []
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
relationship: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0090156
name: intracellular sphingolipid homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of sphingolipids within a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cellular sphingolipid homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0090158
name: endoplasmic reticulum membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "endoplasmic reticulum membrane organisation" EXACT [GOC:mah]
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0090159
name: sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "sphingolipid biosynthesis involved in endoplasmic reticulum membrane organisation" EXACT [GOC:mah]
is_a: GO:0030148 ! sphingolipid biosynthetic process
relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization

[Term]
id: GO:0090160
name: Golgi to lysosome transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006896 ! Golgi to vacuole transport
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0016482 ! cytosolic transport

[Term]
id: GO:0090161
name: Golgi ribbon formation
namespace: biological_process
def: "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization

[Term]
id: GO:0090162
name: establishment of epithelial cell polarity
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity

[Term]
id: GO:0090163
name: establishment of epithelial cell planar polarity
namespace: biological_process
def: "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090162 ! establishment of epithelial cell polarity

[Term]
id: GO:0090164
name: asymmetric Golgi ribbon formation
namespace: biological_process
def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090161 ! Golgi ribbon formation
relationship: part_of GO:0090162 ! establishment of epithelial cell polarity

[Term]
id: GO:0090165
name: regulation of secretion by asymmetric Golgi ribbon formation
namespace: biological_process
def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090164 ! asymmetric Golgi ribbon formation

[Term]
id: GO:0090166
name: Golgi disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi apparatus disassembly" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:1903008 ! organelle disassembly
relationship: part_of GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090167
name: Golgi distribution to daughter cells
namespace: biological_process
def: "Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi apparatus distribution to daughter cells" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0051645 ! Golgi localization
relationship: part_of GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090168
name: Golgi reassembly
namespace: biological_process
def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi apparatus reassembly" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090169
name: regulation of spindle assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090224 ! regulation of spindle organization
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0051225 ! spindle assembly

[Term]
id: GO:0090170
name: regulation of Golgi inheritance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:1903358 ! regulation of Golgi organization
relationship: regulates GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090171
name: chondrocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0002063 ! chondrocyte development

[Term]
id: GO:0090172
name: obsolete microtubule cytoskeleton organization involved in homologous chromosome segregation
namespace: biological_process
def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term was added in error.
synonym: "microtubule cytoskeleton organisation involved in homologous chromosome segregation" EXACT [GOC:mah]
synonym: "microtubule organization involved in chromosome pairing" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0090173
name: regulation of synaptonemal complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0007130 ! synaptonemal complex assembly

[Term]
id: GO:0090174
name: organelle membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048284 ! organelle fusion
is_a: GO:0061025 ! membrane fusion

[Term]
id: GO:0090175
name: regulation of establishment of planar polarity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090176
name: microtubule cytoskeleton organization involved in establishment of planar polarity
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "microtubule cytoskeleton organisation involved in establishment of planar polarity" EXACT [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090177
name: establishment of planar polarity involved in neural tube closure
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042249 ! establishment of planar polarity of embryonic epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0090178
name: regulation of establishment of planar polarity involved in neural tube closure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090175 ! regulation of establishment of planar polarity
relationship: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure

[Term]
id: GO:0090179
name: obsolete planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:0090180
name: positive regulation of thiamine biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:dph, GOC:tb]
synonym: "positive regulation of thiamin biosynthetic process" EXACT []
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0070623 ! regulation of thiamine biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0009228 ! thiamine biosynthetic process

[Term]
id: GO:0090181
name: regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0008203 ! cholesterol metabolic process

[Term]
id: GO:0090182
name: regulation of secretion of lysosomal enzymes
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0033299 ! secretion of lysosomal enzymes

[Term]
id: GO:0090183
name: regulation of kidney development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0001822 ! kidney development

[Term]
id: GO:0090184
name: positive regulation of kidney development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
relationship: positively_regulates GO:0001822 ! kidney development

[Term]
id: GO:0090185
name: negative regulation of kidney development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
relationship: negatively_regulates GO:0001822 ! kidney development

[Term]
id: GO:0090186
name: regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:0090187
name: positive regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0090186 ! regulation of pancreatic juice secretion
relationship: positively_regulates GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:0090188
name: negative regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:0090186 ! regulation of pancreatic juice secretion
relationship: negatively_regulates GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:0090189
name: regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:0090183 ! regulation of kidney development
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0090190
name: positive regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0090191
name: negative regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0090192
name: regulation of glomerulus development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0032835 ! glomerulus development

[Term]
id: GO:0090193
name: positive regulation of glomerulus development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:0090192 ! regulation of glomerulus development
relationship: positively_regulates GO:0032835 ! glomerulus development

[Term]
id: GO:0090194
name: negative regulation of glomerulus development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:0090192 ! regulation of glomerulus development
relationship: negatively_regulates GO:0032835 ! glomerulus development

[Term]
id: GO:0090199
name: regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly regulate this process.
is_a: GO:0010821 ! regulation of mitochondrion organization
relationship: regulates GO:0001836 ! release of cytochrome c from mitochondria

[Term]
id: GO:0090200
name: positive regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria
relationship: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria

[Term]
id: GO:0090201
name: negative regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process.
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
relationship: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria

[Term]
id: GO:0090202
name: obsolete gene looping
namespace: biological_process
def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19923429, PMID:19933150]
comment: This term was obsoleted because it was defined like a molecular function.
is_obsolete: true
consider: GO:0140587

[Term]
id: GO:0090203
name: obsolete transcriptional activation by promoter-terminator looping
namespace: biological_process
def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:dph, GOC:rb, GOC:tb]
comment: This term was obsoleted because it was defined like a molecular function.
synonym: "transcriptional activation by memory gene loops" RELATED [GOC:dph, GOC:rb, GOC:tb]
is_obsolete: true
consider: GO:0045893

[Term]
id: GO:0090204
name: protein localization to nuclear pore
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a nuclear pore." [GOC:dph, GOC:rb, GOC:tb]
synonym: "protein localisation to nuclear pore" EXACT [GOC:mah]
is_a: GO:0090435 ! protein localization to nuclear envelope

[Term]
id: GO:0090205
name: positive regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
relationship: positively_regulates GO:0008203 ! cholesterol metabolic process

[Term]
id: GO:0090206
name: negative regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
relationship: negatively_regulates GO:0008203 ! cholesterol metabolic process

[Term]
id: GO:0090207
name: regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0090208
name: positive regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: positively_regulates GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0090209
name: negative regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: negatively_regulates GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0090210
name: regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb]
synonym: "regulation of establishment of BBB" EXACT [PMID:20080302]
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0090211
name: positive regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of establishment of BBB" EXACT [PMID:20080302]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0090210 ! regulation of establishment of blood-brain barrier
relationship: positively_regulates GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0090212
name: negative regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb]
synonym: "negative regulation of establishment of BBB" EXACT [PMID:20080302]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0090210 ! regulation of establishment of blood-brain barrier
relationship: negatively_regulates GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0090213
name: regulation of radial pattern formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:tb]
synonym: "regulation of radial pattern specification" NARROW [GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009956 ! radial pattern formation

[Term]
id: GO:0090214
name: spongiotrophoblast layer developmental growth
namespace: biological_process
def: "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state." [GOC:dph, GOC:tb]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0060712 ! spongiotrophoblast layer development

[Term]
id: GO:0090215
name: obsolete regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090216
name: obsolete positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008047

[Term]
id: GO:0090217
name: obsolete negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0004857

[Term]
id: GO:0090218
name: positive regulation of lipid kinase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:0045834 ! positive regulation of lipid metabolic process

[Term]
id: GO:0090219
name: negative regulation of lipid kinase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:0045833 ! negative regulation of lipid metabolic process

[Term]
id: GO:0090220
name: chromosome localization to nuclear envelope involved in homologous chromosome segregation
namespace: biological_process
def: "The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287]
synonym: "chromosome localisation to nuclear envelope involved in homologous chromosome segregation" EXACT [GOC:mah]
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0090221
name: mitotic spindle-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0090222
name: centrosome-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center

[Term]
id: GO:0090223
name: chromatin-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0090224
name: regulation of spindle organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of spindle organisation" EXACT [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0007051 ! spindle organization

[Term]
id: GO:0090225
name: obsolete regulation of spindle density
namespace: biological_process
def: "OBSOLETE. Any process that modulates the number of microtubules in a given region of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0090226
name: obsolete regulation of microtubule nucleation by Ran protein signal transduction
namespace: biological_process
def: "OBSOLETE. The series of molecular signals in which a Ran GTPase relays a signal resulting in the modulation of the rate, frequency or extent of microtubule nucleation." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents an annotation.
is_obsolete: true
replaced_by: GO:0010968

[Term]
id: GO:0090227
name: regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "regulation of phytochrome signaling pathway" EXACT [GOC:tb]
synonym: "regulation of red or far-red light signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:2000030 ! regulation of response to red or far red light
relationship: regulates GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0090228
name: positive regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "positive regulation of phytochrome signaling pathway" EXACT [GOC:tb]
synonym: "positive regulation of red or far-red light signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0090227 ! regulation of red or far-red light signaling pathway
relationship: positively_regulates GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0090229
name: negative regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "negative regulation of phytochrome signaling pathway" EXACT [GOC:tb]
synonym: "negative regulation of red or far-red light signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0090227 ! regulation of red or far-red light signaling pathway
relationship: negatively_regulates GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0090230
name: regulation of centromere complex assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "centromere licensing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0034508 ! centromere complex assembly

[Term]
id: GO:0090231
name: regulation of spindle checkpoint
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
is_a: GO:1901976 ! regulation of cell cycle checkpoint
relationship: regulates GO:0031577 ! spindle checkpoint signaling

[Term]
id: GO:0090232
name: positive regulation of spindle checkpoint
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090231 ! regulation of spindle checkpoint
is_a: GO:1901978 ! positive regulation of cell cycle checkpoint
relationship: positively_regulates GO:0031577 ! spindle checkpoint signaling

[Term]
id: GO:0090233
name: negative regulation of spindle checkpoint
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
synonym: "spindle checkpoint silencing" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090231 ! regulation of spindle checkpoint
is_a: GO:1901977 ! negative regulation of cell cycle checkpoint
relationship: negatively_regulates GO:0031577 ! spindle checkpoint signaling

[Term]
id: GO:0090234
name: regulation of kinetochore assembly
namespace: biological_process
alt_id: GO:1901719
def: "Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of NMS complex assembly" NARROW []
is_a: GO:0090230 ! regulation of centromere complex assembly
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0051382 ! kinetochore assembly

[Term]
id: GO:0090235
name: regulation of metaphase plate congression
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0051310 ! metaphase chromosome alignment

[Term]
id: GO:0090236
name: obsolete regulation of transcription from RNA polymerase II promoter involved in somitogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0001756
consider: GO:0006357

[Term]
id: GO:0090237
name: regulation of arachidonate secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:dph, GOC:tb]
synonym: "regulation of arachidonic acid secretion" EXACT []
is_a: GO:0032303 ! regulation of icosanoid secretion
relationship: regulates GO:0050482 ! arachidonate secretion

[Term]
id: GO:0090238
name: positive regulation of arachidonate secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of arachidonic acid secretion" EXACT []
is_a: GO:0032305 ! positive regulation of icosanoid secretion
is_a: GO:0090237 ! regulation of arachidonate secretion
relationship: positively_regulates GO:0050482 ! arachidonate secretion

[Term]
id: GO:0090239
name: obsolete regulation of histone H4 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090240
name: obsolete positive regulation of histone H4 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090241
name: obsolete negative regulation of histone H4 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090242
name: obsolete retinoic acid receptor signaling pathway involved in somitogenesis
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a pre-composed term that should be annotated as a GO-CAM model.
synonym: "retinoic acid receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0001756
consider: GO:0048384

[Term]
id: GO:0090243
name: fibroblast growth factor receptor signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "fibroblast growth factor receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090244
name: Wnt signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Wnt receptor signaling pathway involved in somitogenesis" EXACT []
synonym: "Wnt receptor signalling" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in somitogenesis" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090245
name: axis elongation involved in somitogenesis
namespace: biological_process
def: "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003401 ! axis elongation
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090246
name: convergent extension involved in somitogenesis
namespace: biological_process
def: "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060028 ! convergent extension involved in axis elongation
relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis

[Term]
id: GO:0090248
name: cell migration involved in somitogenic axis elongation
namespace: biological_process
alt_id: GO:0090247
def: "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cell motility involved in somitogenic axis elongation" BROAD []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis

[Term]
id: GO:0090249
name: regulation of cell migration involved in somitogenic axis elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of cell motility involved in somitogenic axis elongation" BROAD []
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0090248 ! cell migration involved in somitogenic axis elongation

[Term]
id: GO:0090250
name: cell-cell adhesion involved in establishment of planar polarity
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090251
name: protein localization involved in establishment of planar polarity
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "protein localisation involved in establishment of planar polarity" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization
relationship: part_of GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090252
name: epithelium migration involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090132 ! epithelium migration
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090253
name: convergent extension involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic animal morphogenesis
is_a: GO:0060029 ! convergent extension involved in organogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090254
name: cell elongation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0009886 ! post-embryonic animal morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090255
name: cell proliferation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090256
name: regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
relationship: regulates GO:0090255 ! cell proliferation involved in imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090257
name: regulation of muscle system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb]
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0003012 ! muscle system process

[Term]
id: GO:0090258
name: negative regulation of mitochondrial fission
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb]
synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
relationship: negatively_regulates GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090259
name: regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf]
is_a: GO:1902667 ! regulation of axon guidance
relationship: regulates GO:0031290 ! retinal ganglion cell axon guidance

[Term]
id: GO:0090260
name: negative regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf]
comment: Note that growth cone collapse has been observed only in assays performed in vitro.
synonym: "axon growth cone collapse" RELATED []
is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance
is_a: GO:1902668 ! negative regulation of axon guidance
relationship: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance

[Term]
id: GO:0090261
name: positive regulation of inclusion body assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090083 ! regulation of inclusion body assembly
relationship: positively_regulates GO:0070841 ! inclusion body assembly

[Term]
id: GO:0090262
name: regulation of transcription-coupled nucleotide-excision repair
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [GOC:tb]
is_a: GO:2000819 ! regulation of nucleotide-excision repair
relationship: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair

[Term]
id: GO:0090263
name: positive regulation of canonical Wnt signaling pathway
namespace: biological_process
alt_id: GO:0035413
def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
synonym: "positive regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "positive regulation of catenin import into nucleus" NARROW []
synonym: "positive regulation of catenin protein nuclear translocation" NARROW [GOC:mah]
synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
relationship: positively_regulates GO:0060070 ! canonical Wnt signaling pathway

[Term]
id: GO:0090264
name: regulation of immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:tb]
is_a: GO:0002697 ! regulation of immune effector process
relationship: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages

[Term]
id: GO:0090265
name: positive regulation of immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:BHF]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0090264 ! regulation of immune complex clearance by monocytes and macrophages
relationship: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages

[Term]
id: GO:0090266
name: regulation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle]
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:1903504 ! regulation of mitotic spindle checkpoint
relationship: regulates GO:0007094 ! mitotic spindle assembly checkpoint signaling

[Term]
id: GO:0090267
name: positive regulation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0090232 ! positive regulation of spindle checkpoint
is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint
relationship: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint signaling

[Term]
id: GO:0090268
name: activation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint." [GOC:mah, GOC:vw]
is_a: GO:0090267 ! positive regulation of mitotic cell cycle spindle assembly checkpoint

[Term]
id: GO:0090269
name: fibroblast growth factor production
namespace: biological_process
def: "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0090270
name: regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0090269 ! fibroblast growth factor production

[Term]
id: GO:0090271
name: positive regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0090270 ! regulation of fibroblast growth factor production
relationship: positively_regulates GO:0090269 ! fibroblast growth factor production

[Term]
id: GO:0090272
name: negative regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0090270 ! regulation of fibroblast growth factor production
relationship: negatively_regulates GO:0090269 ! fibroblast growth factor production

[Term]
id: GO:0090273
name: regulation of somatostatin secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0070253 ! somatostatin secretion

[Term]
id: GO:0090274
name: positive regulation of somatostatin secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0070253 ! somatostatin secretion

[Term]
id: GO:0090275
name: negative regulation of somatostatin secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0070253 ! somatostatin secretion

[Term]
id: GO:0090276
name: regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0090277
name: positive regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: positively_regulates GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0090278
name: negative regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: negatively_regulates GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0090279
name: regulation of calcium ion import
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
synonym: "regulation of transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: regulates GO:0070509 ! calcium ion import

[Term]
id: GO:0090280
name: positive regulation of calcium ion import
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
synonym: "positive regulation of transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:0090279 ! regulation of calcium ion import
relationship: positively_regulates GO:0070509 ! calcium ion import

[Term]
id: GO:0090281
name: negative regulation of calcium ion import
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
synonym: "negative regulation of transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:0090279 ! regulation of calcium ion import
relationship: negatively_regulates GO:0070509 ! calcium ion import

[Term]
id: GO:0090282
name: obsolete positive regulation of transcription involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:rn, PMID:10747051, PMID:10894548, PMID:10899128, PMID:10959837]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "activation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn]
synonym: "positive regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn]
is_obsolete: true
consider: GO:0000086
consider: GO:0045944

[Term]
id: GO:0090283
name: obsolete regulation of protein glycosylation in Golgi
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb]
comment: This term was obsoleted because it represented both a process and a cellular component.
synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0060049

[Term]
id: GO:0090284
name: obsolete positive regulation of protein glycosylation in Golgi
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb]
comment: This term was obsoleted because it represented both a process and a cellular component.
synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0060050

[Term]
id: GO:0090285
name: obsolete negative regulation of protein glycosylation in Golgi
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb]
comment: This term was obsoleted because it represented both a process and a cellular component.
synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
is_obsolete: true
replaced_by: GO:0060051

[Term]
id: GO:0090286
name: obsolete cytoskeletal anchoring at nuclear membrane
namespace: biological_process
def: "OBSOLETE. The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane." [GOC:tb]
comment: This term was obsoleted because it represented a molecular function.
is_obsolete: true
consider: GO:0140444

[Term]
id: GO:0090287
name: regulation of cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0090288
name: negative regulation of cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0090289
name: regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: regulates GO:0002158 ! osteoclast proliferation

[Term]
id: GO:0090290
name: positive regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
relationship: positively_regulates GO:0002158 ! osteoclast proliferation

[Term]
id: GO:0090291
name: negative regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
relationship: negatively_regulates GO:0002158 ! osteoclast proliferation

[Term]
id: GO:0090292
name: nuclear matrix anchoring at nuclear membrane
namespace: biological_process
def: "The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane." [GOC:tb]
synonym: "nucleoskeleton anchoring at nuclear membrane" EXACT [GOC:tb]
is_a: GO:0043578 ! nuclear matrix organization
is_a: GO:0051457 ! maintenance of protein location in nucleus

[Term]
id: GO:0090293
name: nitrogen catabolite regulation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072]
synonym: "regulation of transcription by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:0031670 ! cellular response to nutrient

[Term]
id: GO:0090294
name: nitrogen catabolite activation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072]
synonym: "positive regulation of transcription by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:0090293 ! nitrogen catabolite regulation of transcription

[Term]
id: GO:0090295
name: nitrogen catabolite repression of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072]
synonym: "negative regulation of transcription by nitrogen catabolites" EXACT [GOC:mah]
synonym: "nitrogen catabolite repression" EXACT [GOC:mah, GOC:rb]
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
is_a: GO:0061984 ! catabolite repression
is_a: GO:0090293 ! nitrogen catabolite regulation of transcription

[Term]
id: GO:0090296
name: regulation of mitochondrial DNA replication
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]
synonym: "regulation of mitochondrial DNA synthesis" RELATED [GOC:tb]
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
relationship: regulates GO:0006264 ! mitochondrial DNA replication

[Term]
id: GO:0090297
name: positive regulation of mitochondrial DNA replication
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]
synonym: "positive regulation of mitochondrial DNA synthesis" RELATED [GOC:tb]
is_a: GO:0090296 ! regulation of mitochondrial DNA replication
is_a: GO:1901860 ! positive regulation of mitochondrial DNA metabolic process
is_a: GO:2000105 ! positive regulation of DNA-templated DNA replication
relationship: positively_regulates GO:0006264 ! mitochondrial DNA replication

[Term]
id: GO:0090298
name: negative regulation of mitochondrial DNA replication
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]
synonym: "negative regulation of mitochondrial DNA synthesis" RELATED [GOC:tb]
is_a: GO:0090296 ! regulation of mitochondrial DNA replication
is_a: GO:1901859 ! negative regulation of mitochondrial DNA metabolic process
is_a: GO:2000104 ! negative regulation of DNA-templated DNA replication
relationship: negatively_regulates GO:0006264 ! mitochondrial DNA replication

[Term]
id: GO:0090299
name: regulation of neural crest formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0014029 ! neural crest formation

[Term]
id: GO:0090300
name: positive regulation of neural crest formation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:0090299 ! regulation of neural crest formation
relationship: positively_regulates GO:0014029 ! neural crest formation

[Term]
id: GO:0090301
name: negative regulation of neural crest formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition
is_a: GO:0090299 ! regulation of neural crest formation
relationship: negatively_regulates GO:0014029 ! neural crest formation

[Term]
id: GO:0090303
name: positive regulation of wound healing
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
is_a: GO:0061041 ! regulation of wound healing
is_a: GO:1903036 ! positive regulation of response to wounding
relationship: positively_regulates GO:0042060 ! wound healing

[Term]
id: GO:0090304
name: nucleic acid metabolic process
namespace: biological_process
def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0090305
name: obsolete nucleic acid phosphodiester bond hydrolysis
namespace: biological_process
def: "OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "nucleic acid cleavage" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0090304

[Term]
id: GO:0090306
name: meiotic spindle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw]
synonym: "spindle assembly involved in meiosis" EXACT []
is_a: GO:0000212 ! meiotic spindle organization
is_a: GO:0051225 ! spindle assembly
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0090307
name: mitotic spindle assembly
namespace: biological_process
def: "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]
synonym: "spindle assembly involved in mitosis" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
is_a: GO:0051225 ! spindle assembly
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0090308
name: obsolete regulation of DNA methylation-dependent heterochromatin formation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "regulation of DNA methylation-dependent heterochromatin assembly" EXACT []
synonym: "regulation of methylation-dependent chromatin silencing" BROAD []
is_obsolete: true

[Term]
id: GO:0090309
name: obsolete positive regulation of DNA methylation-dependent heterochromatin formation
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]
comment: The reason for obsoletion is that this term was added in error. There is no evidence for this biological process.
synonym: "positive regulation of DNA methylation-dependent heterochromatin assembly" EXACT []
synonym: "positive regulation of methylation-dependent chromatin silencing" BROAD []
is_obsolete: true

[Term]
id: GO:0090310
name: negative regulation of DNA methylation-dependent heterochromatin formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]
synonym: "negative regulation of DNA methylation-dependent heterochromatin assembly" EXACT []
synonym: "negative regulation of methylation-dependent chromatin silencing" BROAD []
is_a: GO:0031452 ! negative regulation of heterochromatin formation
relationship: negatively_regulates GO:0006346 ! DNA methylation-dependent constitutive heterochromatin formation

[Term]
id: GO:0090311
name: regulation of protein deacetylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid deacetylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0006476 ! protein deacetylation

[Term]
id: GO:0090312
name: positive regulation of protein deacetylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ecd, PMID:20027304]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of protein amino acid deacetylation" EXACT [GOC:bf]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0090311 ! regulation of protein deacetylation
relationship: positively_regulates GO:0006476 ! protein deacetylation

[Term]
id: GO:0090313
name: regulation of protein targeting to membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]
is_a: GO:1903533 ! regulation of protein targeting
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:0006612 ! protein targeting to membrane

[Term]
id: GO:0090314
name: positive regulation of protein targeting to membrane
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]
is_a: GO:0090313 ! regulation of protein targeting to membrane
is_a: GO:1904951 ! positive regulation of establishment of protein localization
is_a: GO:1905477 ! positive regulation of protein localization to membrane
relationship: positively_regulates GO:0006612 ! protein targeting to membrane

[Term]
id: GO:0090315
name: negative regulation of protein targeting to membrane
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]
is_a: GO:0090313 ! regulation of protein targeting to membrane
is_a: GO:1904950 ! negative regulation of establishment of protein localization
is_a: GO:1905476 ! negative regulation of protein localization to membrane
relationship: negatively_regulates GO:0006612 ! protein targeting to membrane

[Term]
id: GO:0090316
name: positive regulation of intracellular protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051222 ! positive regulation of protein transport
relationship: positively_regulates GO:0006886 ! intracellular protein transport

[Term]
id: GO:0090317
name: negative regulation of intracellular protein transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051224 ! negative regulation of protein transport
relationship: negatively_regulates GO:0006886 ! intracellular protein transport

[Term]
id: GO:0090318
name: regulation of chylomicron remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "regulation of chylomicron remodelling" EXACT []
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0034371 ! chylomicron remodeling

[Term]
id: GO:0090319
name: positive regulation of chylomicron remodeling
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF]
synonym: "positive regulation of chylomicron remodelling" EXACT []
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090318 ! regulation of chylomicron remodeling
relationship: positively_regulates GO:0034371 ! chylomicron remodeling

[Term]
id: GO:0090320
name: regulation of chylomicron remnant clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
relationship: regulates GO:0034382 ! chylomicron remnant clearance

[Term]
id: GO:0090321
name: positive regulation of chylomicron remnant clearance
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF]
is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance
is_a: GO:0090320 ! regulation of chylomicron remnant clearance
relationship: positively_regulates GO:0034382 ! chylomicron remnant clearance

[Term]
id: GO:0090322
name: regulation of superoxide metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:tb]
synonym: "regulation of superoxide metabolism" EXACT [GOC:tb]
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
relationship: regulates GO:0006801 ! superoxide metabolic process

[Term]
id: GO:0090323
name: prostaglandin secretion involved in immune response
namespace: biological_process
def: "The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring." [GOC:dph, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0032310 ! prostaglandin secretion
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0090324
name: negative regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:BHF]
is_a: GO:0002082 ! regulation of oxidative phosphorylation
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0090325
name: regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior

[Term]
id: GO:0090326
name: positive regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior
relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior

[Term]
id: GO:0090327
name: negative regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior
relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior

[Term]
id: GO:0090328
name: regulation of olfactory learning
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb]
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0008355 ! olfactory learning

[Term]
id: GO:0090329
name: regulation of DNA-templated DNA replication
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized." [GOC:dph, GOC:tb]
synonym: "regulation of DNA-dependent DNA replication" EXACT []
is_a: GO:0006275 ! regulation of DNA replication
relationship: regulates GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:0090330
name: regulation of platelet aggregation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:dph, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
relationship: regulates GO:0070527 ! platelet aggregation

[Term]
id: GO:0090331
name: negative regulation of platelet aggregation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF]
synonym: "platelet disaggregation" NARROW [GOC:dph, PMID:12871378]
is_a: GO:0010544 ! negative regulation of platelet activation
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:0090330 ! regulation of platelet aggregation
relationship: negatively_regulates GO:0070527 ! platelet aggregation

[Term]
id: GO:0090332
name: stomatal closure
namespace: biological_process
def: "The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb]
is_a: GO:0010118 ! stomatal movement

[Term]
id: GO:0090333
name: regulation of stomatal closure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb]
is_a: GO:0010119 ! regulation of stomatal movement
relationship: regulates GO:0090332 ! stomatal closure

[Term]
id: GO:0090334
name: regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:tb]
synonym: "regulation of cell wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "regulation of cell wall 1,3-beta-glucan biosynthetic process" BROAD []
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: regulates GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0090335
name: regulation of brown fat cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:tb]
is_a: GO:0045598 ! regulation of fat cell differentiation
relationship: regulates GO:0050873 ! brown fat cell differentiation

[Term]
id: GO:0090336
name: positive regulation of brown fat cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:BHF]
is_a: GO:0045600 ! positive regulation of fat cell differentiation
is_a: GO:0090335 ! regulation of brown fat cell differentiation
relationship: positively_regulates GO:0050873 ! brown fat cell differentiation

[Term]
id: GO:0090337
name: regulation of formin-nucleated actin cable assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]
is_a: GO:0032231 ! regulation of actin filament bundle assembly
relationship: regulates GO:0070649 ! formin-nucleated actin cable assembly

[Term]
id: GO:0090338
name: positive regulation of formin-nucleated actin cable assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]
is_a: GO:0032233 ! positive regulation of actin filament bundle assembly
is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly
relationship: positively_regulates GO:0070649 ! formin-nucleated actin cable assembly

[Term]
id: GO:0090339
name: negative regulation of formin-nucleated actin cable assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]
is_a: GO:0032232 ! negative regulation of actin filament bundle assembly
is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly
relationship: negatively_regulates GO:0070649 ! formin-nucleated actin cable assembly

[Term]
id: GO:0090340
name: positive regulation of secretion of lysosomal enzymes
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes
relationship: positively_regulates GO:0033299 ! secretion of lysosomal enzymes

[Term]
id: GO:0090341
name: negative regulation of secretion of lysosomal enzymes
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes
relationship: negatively_regulates GO:0033299 ! secretion of lysosomal enzymes

[Term]
id: GO:0090342
name: obsolete regulation of cell aging
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true
consider: GO:2000772

[Term]
id: GO:0090343
name: obsolete positive regulation of cell aging
namespace: biological_process
def: "OBSOLETE. Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0090344
name: obsolete negative regulation of cell aging
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0090345
name: organohalogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0090346
name: organofluorine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0090347
name: regulation of organohalogen metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0090348
name: regulation of organofluorine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0090347 ! regulation of organohalogen metabolic process
relationship: regulates GO:0090346 ! organofluorine metabolic process

[Term]
id: GO:0090349
name: negative regulation of organohalogen metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0090347 ! regulation of organohalogen metabolic process
relationship: negatively_regulates GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0090350
name: negative regulation of organofluorine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0090348 ! regulation of organofluorine metabolic process
is_a: GO:0090349 ! negative regulation of organohalogen metabolic process
relationship: negatively_regulates GO:0090346 ! organofluorine metabolic process

[Term]
id: GO:0090351
name: seedling development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge." [GOC:tb, PO:0007131]
xref: PO:0008037
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0090352
name: regulation of nitrate assimilation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances." [GOC:tb]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
relationship: regulates GO:0042128 ! nitrate assimilation

[Term]
id: GO:0090353
name: polygalacturonase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of polygalacturonase." [GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0090354
name: regulation of auxin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb]
synonym: "regulation of auxin metabolism" EXACT [GOC:tb]
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0009850 ! auxin metabolic process

[Term]
id: GO:0090355
name: positive regulation of auxin metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb]
synonym: "positive regulation of auxin metabolism" EXACT [GOC:tb]
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0090354 ! regulation of auxin metabolic process
relationship: positively_regulates GO:0009850 ! auxin metabolic process

[Term]
id: GO:0090356
name: negative regulation of auxin metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb]
synonym: "negative regulation of auxin metabolism" EXACT [GOC:tb]
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0090354 ! regulation of auxin metabolic process
relationship: negatively_regulates GO:0009850 ! auxin metabolic process

[Term]
id: GO:0090357
name: regulation of tryptophan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb]
synonym: "regulation of tryptophan metabolism" EXACT [GOC:tb]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006568 ! tryptophan metabolic process

[Term]
id: GO:0090358
name: positive regulation of tryptophan metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb]
synonym: "positive regulation of tryptophan metabolism" EXACT [GOC:tb]
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0090357 ! regulation of tryptophan metabolic process
relationship: positively_regulates GO:0006568 ! tryptophan metabolic process

[Term]
id: GO:0090359
name: negative regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:tb]
synonym: "negative regulation of abscisic acid biosynthesis" EXACT [GOC:tb]
is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0009688 ! abscisic acid biosynthetic process

[Term]
id: GO:0090360
name: platelet-derived growth factor production
namespace: biological_process
def: "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0090361
name: regulation of platelet-derived growth factor production
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0090360 ! platelet-derived growth factor production

[Term]
id: GO:0090362
name: positive regulation of platelet-derived growth factor production
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0090361 ! regulation of platelet-derived growth factor production
relationship: positively_regulates GO:0090360 ! platelet-derived growth factor production

[Term]
id: GO:0090363
name: regulation of proteasome core complex assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [GOC:dph, GOC:elh, GOC:tb]
is_a: GO:0090364 ! regulation of proteasome assembly
relationship: regulates GO:0080129 ! proteasome core complex assembly

[Term]
id: GO:0090364
name: regulation of proteasome assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:dph, GOC:elh, GOC:tb]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0043248 ! proteasome assembly

[Term]
id: GO:0090365
name: regulation of mRNA modification
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb, PMID:14559896]
synonym: "regulation of mRNA editing" NARROW []
is_a: GO:1903311 ! regulation of mRNA metabolic process
relationship: regulates GO:0016556 ! mRNA modification

[Term]
id: GO:0090366
name: positive regulation of mRNA modification
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0090365 ! regulation of mRNA modification
is_a: GO:1903313 ! positive regulation of mRNA metabolic process
relationship: positively_regulates GO:0016556 ! mRNA modification

[Term]
id: GO:0090367
name: negative regulation of mRNA modification
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0090365 ! regulation of mRNA modification
is_a: GO:1903312 ! negative regulation of mRNA metabolic process
relationship: negatively_regulates GO:0016556 ! mRNA modification

[Term]
id: GO:0090368
name: regulation of ornithine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0090369
name: ornithine carbamoyltransferase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0090370
name: negative regulation of cholesterol efflux
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0010874 ! regulation of cholesterol efflux
is_a: GO:0032375 ! negative regulation of cholesterol transport
relationship: negatively_regulates GO:0033344 ! cholesterol efflux

[Term]
id: GO:0090371
name: regulation of glycerol transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb]
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:0015793 ! glycerol transmembrane transport

[Term]
id: GO:0090372
name: positive regulation of glycerol transport
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0090371 ! regulation of glycerol transport
relationship: positively_regulates GO:0015793 ! glycerol transmembrane transport

[Term]
id: GO:0090373
name: negative regulation of glycerol transport
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0090371 ! regulation of glycerol transport
relationship: negatively_regulates GO:0015793 ! glycerol transmembrane transport

[Term]
id: GO:0090374
name: oligopeptide export from mitochondrion
namespace: biological_process
def: "The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0170037 ! export from the mitochondrion

[Term]
id: GO:0090375
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:tb]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:tb]
is_obsolete: true
consider: GO:0000122
consider: GO:0010106

[Term]
id: GO:0090376
name: seed trichome differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function." [GOC:tb, PMID:17905721]
synonym: "cotton fiber development" NARROW [GOC:tb]
synonym: "seed hair differentiation" EXACT [PO:0004511]
synonym: "seed trichome development" RELATED [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010026 ! trichome differentiation
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0090377
name: seed trichome initiation
namespace: biological_process
def: "The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis." [PMID:17905721]
comment: These processes continue up to 3 days post-anthesis (DPA) in Gossypium spp.
synonym: "seed trichome fate commitment" EXACT [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0090376 ! seed trichome differentiation

[Term]
id: GO:0090378
name: seed trichome elongation
namespace: biological_process
def: "The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [GOC:tb]
comment: The increase in length of the seed trichome without cell division. Elongation is defined to be from 5 to 20 DPA in Gossypium spp.
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0090376 ! seed trichome differentiation

[Term]
id: GO:0090379
name: secondary cell wall biogenesis involved in seed trichome differentiation
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete." [GOC:tb]
comment: The processes involved in the massive amount of secondary wall cellulose synthesis in seed trichomes continue to 30 DPA in Gossypium spp.
synonym: "secondary cell wall biosynthesis involved in seed trichome differentiation" EXACT [GOC:tb]
synonym: "seed trichome secondary wall biosynthesis" RELATED [GOC:tb]
is_a: GO:0009834 ! plant-type secondary cell wall biogenesis
relationship: part_of GO:0090376 ! seed trichome differentiation

[Term]
id: GO:0090380
name: seed trichome maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state." [GOC:tb]
comment: These processes continue to 60 DPA in Gossypium spp.
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0090376 ! seed trichome differentiation

[Term]
id: GO:0090381
name: regulation of heart induction
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:dph, GOC:tb]
is_a: GO:0003156 ! regulation of animal organ formation
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000826 ! regulation of heart morphogenesis
relationship: regulates GO:0003129 ! heart induction

[Term]
id: GO:0090382
name: phagosome maturation
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0090383
name: phagosome acidification
namespace: biological_process
def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion." [GOC:kmv, GOC:tb]
synonym: "phagosomal acidification" EXACT [GOC:kmv, GOC:tb]
is_a: GO:0051452 ! intracellular pH reduction
relationship: part_of GO:0090382 ! phagosome maturation

[Term]
id: GO:0090384
name: phagosome-lysosome docking
namespace: biological_process
def: "The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb]
synonym: "lysosome recruitment to phagosome" EXACT [GOC:kmv, GOC:tb]
is_a: GO:0048278 ! vesicle docking
relationship: part_of GO:0001845 ! phagolysosome assembly

[Term]
id: GO:0090385
name: phagosome-lysosome fusion
namespace: biological_process
def: "The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0001845 ! phagolysosome assembly

[Term]
id: GO:0090386
name: phagosome maturation involved in apoptotic cell clearance
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb]
is_a: GO:0090382 ! phagosome maturation
relationship: part_of GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:0090387
name: phagolysosome assembly involved in apoptotic cell clearance
namespace: biological_process
def: "The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
is_a: GO:0001845 ! phagolysosome assembly
relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance

[Term]
id: GO:0090388
name: phagosome-lysosome docking involved in apoptotic cell clearance
namespace: biological_process
def: "The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb]
is_a: GO:0090384 ! phagosome-lysosome docking
relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance

[Term]
id: GO:0090389
name: phagosome-lysosome fusion involved in apoptotic cell clearance
namespace: biological_process
def: "The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
is_a: GO:0090385 ! phagosome-lysosome fusion
relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance

[Term]
id: GO:0090390
name: phagosome acidification involved in apoptotic cell clearance
namespace: biological_process
def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
is_a: GO:0090383 ! phagosome acidification
relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance

[Term]
id: GO:0090391
name: granum assembly
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts." [GOC:tb]
synonym: "grana formation" EXACT [GOC:tb]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0009658 ! chloroplast organization

[Term]
id: GO:0090392
name: sepal giant cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C." [GOC:tb, PMID:20485493]
is_a: GO:0090627 ! plant epidermal cell differentiation

[Term]
id: GO:0090393
name: sepal giant cell development
namespace: biological_process
def: "The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:tb]
synonym: "sepal giant cell formation" RELATED [GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0090392 ! sepal giant cell differentiation

[Term]
id: GO:0090394
name: negative regulation of excitatory postsynaptic potential
namespace: biological_process
def: "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:BHF]
synonym: "negative regulation of EPSP" RELATED []
synonym: "negative regulation of excitatory post-synaptic membrane potential" EXACT []
synonym: "reduction of excitatory postsynaptic membrane potential" EXACT [GOC:bf]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
relationship: negatively_regulates GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:0090395
name: plant cell papilla
namespace: cellular_component
def: "A cell projection that is a short, rounded projection from a plant epidermal cell." [GOC:tb]
comment: Part of papilla cell (PO:0025166), which is a shoot epidermal cell (PO:0025165) in plants. Replaces the obsolete term papillae (PO:0002001).
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0090396
name: leaf papilla
namespace: cellular_component
def: "A plant cell papilla that is part of a leaf papilla cell." [GOC:tb]
comment: Part of leaf papilla cell (PO:0025167).
is_a: GO:0090395 ! plant cell papilla

[Term]
id: GO:0090397
name: stigma papilla
namespace: cellular_component
def: "A plant cell papilla that is part of a stigma papilla cell." [GOC:tb]
comment: Part of stigma papilla cell (PO:0025168).
is_a: GO:0090395 ! plant cell papilla

[Term]
id: GO:0090398
name: cellular senescence
namespace: biological_process
def: "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF, PMID:28682291]
is_a: GO:0008152 ! metabolic process
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0090399
name: replicative senescence
namespace: biological_process
def: "A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging." [GOC:BHF]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0090400
name: stress-induced premature senescence
namespace: biological_process
def: "A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays." [GOC:BHF]
synonym: "SIPS" EXACT [GOC:BHF]
is_a: GO:0090398 ! cellular senescence

[Term]
id: GO:0090401
name: obsolete viral-induced premature senescence
namespace: biological_process
def: "OBSOLETE. A cellular senescence process associated with the dismantling of a cell as a response to viral infection." [GOC:BHF]
comment: The reason for obsoletion is was not clearly defined. There is nothing in the literature that mentions this process; there are papers that mention viral proteins overcoming premature senescence, for example, PMID:22326283.
is_obsolete: true

[Term]
id: GO:0090402
name: oncogene-induced cell senescence
namespace: biological_process
def: "A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family." [GOC:BHF]
synonym: "OIS" EXACT [GOC:BHF]
is_a: GO:0090398 ! cellular senescence

[Term]
id: GO:0090403
name: oxidative stress-induced premature senescence
namespace: biological_process
def: "A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals." [GOC:BHF]
is_a: GO:0090400 ! stress-induced premature senescence
relationship: part_of GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0090404
name: pollen tube tip
namespace: cellular_component
def: "The region at growing end of the pollen tube cell, where polarized growth occurs." [GOC:tb, PO:0025195, PO:0025281]
is_a: GO:0035838 ! growing cell tip
relationship: part_of GO:0090406 ! pollen tube

[Term]
id: GO:0090405
name: unicellular trichome branch
namespace: cellular_component
def: "A cell projection part that is a branch of a unicellular trichome." [GOC:tb, PO:0025537]
comment: Unicellular trichome (PO:0025537) is a trichome(PO:0000282) that is a single plant cell (PO:0009002). For a cell that forms a branch of a multicellular trichome, see multicellular trichome branch cell (PO:0025163).
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0090406
name: pollen tube
namespace: cellular_component
def: "A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain." [GOC:tb, PO:0025195, PO:0025281]
comment: Carries the male gametes to into or near the ovule. May be branched in gymnosperms. This term replaces the obsolete term PO:0006345. Part of pollen tube cell (PO:0025195).
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0090407
name: organophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0090408
name: phloem nitrate loading
namespace: biological_process
def: "The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:tb]
is_a: GO:0015706 ! nitrate transmembrane transport
is_a: GO:0110126 ! phloem loading

[Term]
id: GO:0090409
name: malonyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate." [RHEA:32139]
xref: EC:6.2.1.76
xref: MetaCyc:RXN-12359
xref: RHEA:32139
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0090410
name: malonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of malonate, the propanedioate ion." [GOC:tb]
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0090411
name: brassinosteroid binding
namespace: molecular_function
def: "Binding to a brassinosteroid." [GOC:tb]
is_a: GO:0005496 ! steroid binding

[Term]
id: GO:0090412
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT []
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0090413
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT []
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:0090414
name: molybdate ion export from vacuole
namespace: biological_process
def: "The directed movement of molybdate ions out of the vacuole." [GOC:tb]
is_a: GO:0015689 ! molybdate ion transport
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:0090415
name: 7-hydroxymethyl chlorophyll a reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O." [GOC:kad, PMID:21934147, RHEA:53544]
xref: EC:1.17.7.2
xref: RHEA:53544
is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

[Term]
id: GO:0090416
name: nicotinate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nicotinate from one side of a membrane to the other." [GOC:tb]
xref: Reactome:R-HSA-8869603 "SLC22A13 transports NCA from extracellular region to cytosol"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0090417
name: N-methylnicotinate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of N-methylnicotinate from one side of a membrane to the other." [GOC:tb]
synonym: "N-methylnicotinate transporter activity" RELATED []
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity

[Term]
id: GO:0090418
name: obsolete positive regulation of transcription involved in S-phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the S phase of the mitotic cell cycle." [PMID:16912276]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "activation of S phase specific transcription in the mitotic cell cycle" RELATED []
synonym: "activation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED []
synonym: "activation of transcription involved in S phase of mitotic cell cycle" RELATED []
synonym: "positive regulation of S phase specific transcription in the mitotic cell cycle" RELATED []
synonym: "positive regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED []
synonym: "positive regulation of transcription involved in S-phase of mitotic cell cycle" EXACT []
synonym: "up-regulation of S phase specific transcription in the mitotic cell cycle" RELATED []
synonym: "up-regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED []
synonym: "up-regulation of transcription involved in S phase of mitotic cell cycle" RELATED []
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0090419
name: obsolete negative regulation of transcription involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:10747051]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down-regulation of transcription from RNA polymerase II promoter during the G2/M transition of the mitotic cell cycle" RELATED []
synonym: "negative regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" RELATED []
is_obsolete: true
consider: GO:0000086
consider: GO:0000122

[Term]
id: GO:0090420
name: obsolete naphthalene-containing compound metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving naphthalene-containing compounds." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is a unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0090421
name: embryonic meristem initiation
namespace: biological_process
def: "Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:tb]
is_a: GO:0010014 ! meristem initiation

[Term]
id: GO:0090422
name: thiamine pyrophosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other." [GOC:tb]
synonym: "thiamine diphosphate transporter activity" EXACT [GOC:tb]
synonym: "thiamine pyrophosphate transporter activity" NARROW []
xref: Reactome:R-HSA-8875838 "SLC25A19 transports ThDP from cytosol to mitochondrial matrix"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015234 ! thiamine transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity

[Term]
id: GO:0090423
name: phytochelatin-metal complex formation
namespace: biological_process
def: "A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex." [GOC:tb]
synonym: "low molecular weight phytochelatin complex formation" RELATED []
synonym: "LWM phytochelatin complex formation" RELATED []
is_a: GO:0046937 ! phytochelatin metabolic process

[Term]
id: GO:0090424
name: phytochelatin-metal-sulfur complex formation
namespace: biological_process
def: "A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex." [GOC:tb]
synonym: "high molecular weight phytochelatin complex formation" RELATED []
synonym: "HWM phytochelatin complex formation" RELATED []
is_a: GO:0046937 ! phytochelatin metabolic process

[Term]
id: GO:0090425
name: acinar cell differentiation
namespace: biological_process
def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb]
is_a: GO:0002067 ! glandular epithelial cell differentiation

[Term]
id: GO:0090426
name: actin filament bundle convergence
namespace: biological_process
def: "A process of actin filament bundle distribution that results in the compaction of actin filaments." [GOC:dph, GOC:tb]
is_a: GO:0070650 ! actin filament bundle distribution

[Term]
id: GO:0090427
name: activation of meiosis
namespace: biological_process
def: "Any process that starts the inactive process of meiosis." [GOC:dph, GOC:tb]
is_a: GO:0045836 ! positive regulation of meiotic nuclear division

[Term]
id: GO:0090428
name: perianth development
namespace: biological_process
def: "The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals." [GOC:tb, PO:0009058]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0090429
name: obsolete detection of endogenous biotic stimulus
namespace: biological_process
def: "OBSOLETE. The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it is an unnecessary grouing term.
is_obsolete: true

[Term]
id: GO:0090430
name: caffeoyl-CoA: alcohol caffeoyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA." [GOC:pz]
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0090431
name: alkyl caffeate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate." [GOC:pz]
synonym: "alkyl caffeate ester anabolism" EXACT [GOC:tb]
synonym: "alkyl caffeate ester biosynthesis" EXACT [GOC:tb]
synonym: "alkyl caffeate ester formation" EXACT [GOC:tb]
synonym: "alkyl caffeate ester synthesis" EXACT [GOC:tb]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0009802 ! cinnamic acid ester biosynthetic process

[Term]
id: GO:0090432
name: myristoyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA." [GOC:al, PMID:18071249]
synonym: "myristoyl-CoA synthetase activity" EXACT []
is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity

[Term]
id: GO:0090433
name: palmitoyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA." [GOC:al, PMID:18071249]
synonym: "palmitoyl-CoA synthetase activity" EXACT []
xref: Reactome:R-HSA-434382 "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell"
is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity

[Term]
id: GO:0090434
name: oleoyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA." [GOC:al, PMID:18071249]
synonym: "oleoyl-CoA synthetase activity" EXACT []
is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity

[Term]
id: GO:0090435
name: protein localization to nuclear envelope
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb]
synonym: "protein localization in nuclear envelope" EXACT []
is_a: GO:0034504 ! protein localization to nucleus

[Term]
id: GO:0090436
name: leaf pavement cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate." [GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0090437
name: socket cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support." [GOC:tb]
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0090558 ! plant epidermis development

[Term]
id: GO:0090438
name: camelliol C synthase activity
namespace: molecular_function
def: "Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C." [GOC:tb, PMID:17985917]
synonym: "(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)" EXACT []
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0090439
name: tetraketide alpha-pyrone synthase activity
namespace: molecular_function
def: "Catalyzes the reaction: 7-hydroxylauroyl-CoA + 3 malonyl-CoA + 2 H+ = 2-(8-hydroxy-2-oxotridecyl)-6-oxopyran-4-olate + 3 CO2 + 4 coenzyme A." [MetaCyc:RXN-16407, PMID:21193570]
xref: MetaCyc:RXN-16407
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0090440
name: abscisic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of abscisic acid from one side of a membrane to the other." [GOC:tb]
synonym: "abscisic acid transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:0090441
name: trehalose biosynthesis in response to heat stress
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb]
synonym: "trehalose biosynthetic process in response to heat stress" EXACT systematic_synonym [GOC:tb]
is_a: GO:0005992 ! trehalose biosynthetic process
is_a: GO:0070414 ! trehalose metabolism in response to heat stress

[Term]
id: GO:0090442
name: trehalose catabolism in response to heat stress
namespace: biological_process
def: "The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb]
synonym: "trehalose catabolic process in response to heat stress" EXACT systematic_synonym [GOC:tb]
is_a: GO:0005993 ! trehalose catabolic process
is_a: GO:0070414 ! trehalose metabolism in response to heat stress
relationship: part_of GO:0010353 ! response to trehalose

[Term]
id: GO:0090443
name: FAR/SIN/STRIPAK complex
namespace: cellular_component
def: "A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body." [GOC:vw, PMID:21561862, PMID:22119525]
synonym: "FAR complex" RELATED [GOC:vw]
synonym: "SIN inhibitory phosphatase (SIP) complex" EXACT []
synonym: "SIN inhibitory phosphatase complex" EXACT []
synonym: "SIP complex" EXACT [PMID:22119525]
synonym: "striatin interacting phosphatase and kinase complex" EXACT [GOC:vw]
synonym: "STRIPAK signalling complex" RELATED [GOC:vw]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0090444
name: regulation of nematode larval development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:17550772]
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0061062 ! regulation of nematode larval development

[Term]
id: GO:0090445
name: positive regulation of nematode larval development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [PMID:17550772]
is_a: GO:0045962 ! positive regulation of development, heterochronic
is_a: GO:0061063 ! positive regulation of nematode larval development
is_a: GO:0090444 ! regulation of nematode larval development, heterochronic

[Term]
id: GO:0090446
name: negative regulation of nematode larval development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [PMID:17550772]
is_a: GO:0045961 ! negative regulation of development, heterochronic
is_a: GO:0061064 ! negative regulation of nematode larval development
is_a: GO:0090444 ! regulation of nematode larval development, heterochronic

[Term]
id: GO:0090447
name: glycerol-3-phosphate 2-O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate." [RHEA:33559]
xref: EC:2.3.1.198
xref: RHEA:33559
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0090448
name: glucosinolate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in)." [PMID:22864417]
synonym: "glucosinolate:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0141165 ! glucosinolate transmembrane transporter activity

[Term]
id: GO:0090449
name: phloem glucosinolate loading
namespace: biological_process
def: "The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [PMID:22864417]
is_a: GO:0110126 ! phloem loading
is_a: GO:1901349 ! glucosinolate transport

[Term]
id: GO:0090451
name: cotyledon boundary formation
namespace: biological_process
def: "The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained." [GOC:tb]
is_a: GO:0090691 ! formation of plant organ boundary

[Term]
id: GO:0090452
name: lithium ion transmembrane transport
namespace: biological_process
def: "The directed movement of lithium ions (Li+) across a membrane." [GOC:tb]
synonym: "lithium ion import" NARROW []
synonym: "lithium ion uptake" EXACT [GOC:tb]
is_a: GO:0010351 ! lithium ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0090453
name: aspartate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of aspartate into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar aspartate import" EXACT [GOC:tb]
is_a: GO:0015810 ! aspartate transmembrane transport
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0034487 ! vacuolar amino acid transmembrane transport

[Term]
id: GO:0090454
name: glutamate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar glutamate import" RELATED [GOC:tb]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0090455
name: ornithine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of ornithine into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar ornithine import" RELATED [GOC:tb]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015822 ! ornithine transport
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0090459
name: intracellular aspartate homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of aspartate within a cell." [GOC:tb]
synonym: "aspartate homeostasis" EXACT []
synonym: "cellular aspartate homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0090460
name: intracellular threonine homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of threonine within a cell." [GOC:tb]
synonym: "cellular threonine homeostasis" EXACT []
synonym: "threonine homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0090461
name: intracellular glutamate homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of glutamate within a cell." [GOC:tb]
synonym: "cellular glutamate homeostasis" EXACT []
synonym: "glutamate homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0090462
name: intracellular ornithine homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of orthinine within a cell." [GOC:tb]
synonym: "cellular ornithine homeostasis" EXACT []
synonym: "ornithine homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0090463
name: intracellular lysine homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of lysine within a cell." [GOC:tb]
synonym: "cellular lysine homeostasis" EXACT []
synonym: "lysine homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0090464
name: intracellular histidine homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of histidine within a cell." [GOC:tb]
synonym: "cellular histidine homeostasis" EXACT []
synonym: "histidine homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0090465
name: intracellular arginine homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of arginine within a cell." [GOC:tb]
synonym: "arginine homeostasis" EXACT []
synonym: "cellular arginine homeostasis" EXACT []
is_a: GO:0080144 ! intracellular amino acid homeostasis

[Term]
id: GO:0090470
name: shoot organ boundary specification
namespace: biological_process
def: "The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained." [PMID:18757555]
is_a: GO:0090691 ! formation of plant organ boundary

[Term]
id: GO:0090471
name: 9,15,9'-tri-cis-zeta-carotene isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene." [RHEA:30967]
synonym: "9,15,9'-tricis-zeta-carotene cis-trans-isomerase" RELATED []
xref: EC:5.2.1.12
xref: MetaCyc:RXN-11354
xref: RHEA:30967
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0090472
name: dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein." [GOC:al]
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0090473
name: lys-arg specific dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein." [GOC:al]
is_a: GO:0090472 ! dibasic protein processing

[Term]
id: GO:0090474
name: arg-arg specific dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein." [GOC:al]
is_a: GO:0090472 ! dibasic protein processing

[Term]
id: GO:0090475
name: lys-lys specific dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein." [GOC:al]
is_a: GO:0090472 ! dibasic protein processing

[Term]
id: GO:0090480
name: purine nucleotide-sugar transmembrane transport
namespace: biological_process
alt_id: GO:0036079
def: "The process in which a purine nucleotide-sugar is transported across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "purine nucleotide-sugar membrane transport" EXACT []
synonym: "purine nucleotide-sugar transport" RELATED []
is_a: GO:0015780 ! nucleotide-sugar transmembrane transport

[Term]
id: GO:0090481
name: pyrimidine nucleotide-sugar transmembrane transport
namespace: biological_process
alt_id: GO:0015781
def: "The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "pyrimidine nucleotide-sugar membrane transport" EXACT []
synonym: "pyrimidine nucleotide-sugar transport" RELATED []
is_a: GO:0015780 ! nucleotide-sugar transmembrane transport

[Term]
id: GO:0090482
name: vitamin transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0051183
def: "Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb]
synonym: "vitamin or cofactor transporter activity" BROAD []
synonym: "vitamin transporter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0090483
name: phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine." [PMID:22988102]
synonym: "cardiolipin synthase" RELATED [GOC:tb]
is_a: GO:0030572 ! phosphatidyltransferase activity

[Term]
id: GO:0090485
name: obsolete chromosome number maintenance
namespace: biological_process
def: "OBSOLETE. The maintenance of the standard number of chromosomes in a cell." [GOC:tb]
comment: The reason for obsoletion is that this term represents a phenotype, and could be captured by other terms such as GO:0007059 chromosome segregation or GO:1903467 negative regulation of mitotic DNA replication initiation.
synonym: "diploidization" RELATED [GOC:tb]
synonym: "haploidization" RELATED [GOC:tb]
is_obsolete: true
consider: GO:0007059
consider: GO:1903467

[Term]
id: GO:0090486
name: small RNA 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide." [GOC:tb, GOC:vw, RHEA:37887]
synonym: "small RNA 2'-O-methyltransferase" EXACT []
xref: EC:2.1.1.386
xref: RHEA:37887
is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity

[Term]
id: GO:0090487
name: secondary metabolite catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:tb]
synonym: "secondary metabolite breakdown" EXACT [GOC:tb]
synonym: "secondary metabolite catabolism" EXACT [GOC:tb]
synonym: "secondary metabolite degradation" EXACT [GOC:tb]
is_a: GO:0009056 ! catabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0090488
name: polo box domain specific binding
namespace: molecular_function
def: "Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases." [GOC:al, GOC:tb, Pfam:PF00659, PMID:12352953]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0090489
name: tryptophan N-monooxygenase activity
namespace: molecular_function
def: "Catalyzes the multi-step reaction: L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H+ + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]." [RHEA:33279]
synonym: "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)" RELATED []
synonym: "tryptophan N-hydroxylase activity" RELATED []
xref: EC:1.14.14.156
xref: KEGG_REACTION:R08160
xref: RHEA:33279
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0090490
name: obsolete L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
namespace: molecular_function
def: "OBSOLETE. Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O." [KEGG_REACTION:R09583]
comment: This term was obsoleted because it represents a sub-reaction of tryptophan N-monooxygenase activity ; GO:0090489.
is_obsolete: true
replaced_by: GO:0090489

[Term]
id: GO:0090491
name: obsolete N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
namespace: molecular_function
def: "OBSOLETE. Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O." [KEGG_REACTION:R09584]
comment: This term was obsoleted because it represents a sub-reaction of tryptophan N-monooxygenase activity ; GO:0090489.
is_obsolete: true
replaced_by: GO:0090489

[Term]
id: GO:0090492
name: obsolete N,N-Dihydroxy-L-tryptophan decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O." [KEGG_REACTION:R09585]
comment: This term was obsoleted because it represents a sub-reaction of tryptophan N-monooxygenase activity ; GO:0090489.
is_obsolete: true
replaced_by: GO:0090489

[Term]
id: GO:0090493
name: catecholamine uptake
namespace: biological_process
def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb]
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0090494
name: dopamine uptake
namespace: biological_process
def: "The directed movement of dopamine into a cell." [GOC:dph, GOC:tb]
is_a: GO:0015872 ! dopamine transport
is_a: GO:0090493 ! catecholamine uptake

[Term]
id: GO:0090495
name: low-density lipoprotein particle disassembly
namespace: biological_process
def: "The disaggregation of a low-density lipoprotein particle into its constituent components." [GOC:dph, GOC:tb]
is_a: GO:0071829 ! plasma lipoprotein particle disassembly

[Term]
id: GO:0090496
name: mesenchyme migration involved in limb bud formation
namespace: biological_process
def: "The migration of mesenchymal tissue that contributes to the formation of a limb bud." [GOC:dph, GOC:tb]
is_a: GO:0090131 ! mesenchyme migration
relationship: part_of GO:0060174 ! limb bud formation

[Term]
id: GO:0090497
name: mesenchymal cell migration
namespace: biological_process
def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0090498
name: extrinsic component of Golgi membrane
namespace: cellular_component
def: "The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, PMID:21337012]
synonym: "extrinsic to Golgi membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0090499
name: pimelyl-[acyl-carrier protein] methyl ester esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H+ + methanol." [PMID:23045647, RHEA:42700]
comment: Note that while this reaction occurs on a modified protein (acyl-carrier protein), the ACP only acts as a carrier that later releases the end product.
synonym: "pimelyl-[acyl-carrier protein] methyl ester hydrolase activity" RELATED []
xref: EC:3.1.1.85
xref: MetaCyc:RXN-11483
xref: RHEA:42700
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0090500
name: endocardial cushion to mesenchymal transition
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, GOC:tb]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition

[Term]
id: GO:0090501
name: obsolete RNA phosphodiester bond hydrolysis
namespace: biological_process
def: "OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090502
name: obsolete RNA phosphodiester bond hydrolysis, endonucleolytic
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090503
name: obsolete RNA phosphodiester bond hydrolysis, exonucleolytic
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090504
name: epiboly
namespace: biological_process
def: "The expansion of one cell sheet over other cells or yolk." [GOC:dph, GOC:tb]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet

[Term]
id: GO:0090505
name: epiboly involved in wound healing
namespace: biological_process
def: "The expansion of one cell sheet over other cells involved in wound healing." [GOC:dph, GOC:tb]
is_a: GO:0090504 ! epiboly
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0090506
name: axillary shoot meristem initiation
namespace: biological_process
def: "A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf." [GOC:tb]
synonym: "axillary bud meristem initiation" RELATED []
is_a: GO:0010014 ! meristem initiation
relationship: part_of GO:0010223 ! secondary shoot formation

[Term]
id: GO:0090507
name: phenylethylamine metabolic process involved in synaptic transmission
namespace: biological_process
def: "The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission." [GOC:tb]
is_a: GO:0042443 ! phenylethylamine metabolic process
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0090508
name: phenylethylamine biosynthetic process involved in synaptic transmission
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission." [GOC:tb]
is_a: GO:0042444 ! phenylethylamine biosynthetic process
is_a: GO:0090507 ! phenylethylamine metabolic process involved in synaptic transmission

[Term]
id: GO:0090510
name: anticlinal cell division
namespace: biological_process
def: "A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file." [GOC:tair_curators, PMID:21391814]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0090511
name: periclinal cell division
namespace: biological_process
def: "A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file." [GOC:tair_curators, PMID:21391814]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0090512
name: eisosome membrane domain/MCC
namespace: cellular_component
def: "A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins." [GOC:al, GOC:vw, PMID:22368779]
is_a: GO:0044853 ! plasma membrane raft
relationship: part_of GO:0032126 ! eisosome

[Term]
id: GO:0090513
name: L-histidine transmembrane import into vacuole
namespace: biological_process
alt_id: GO:0090457
def: "The directed movement of L-histidine into the vacuole across the vacuolar membrane." [GOC:al]
synonym: "histidine transmembrane import into vacuole" BROAD []
synonym: "vacuolar histidine import" BROAD [GOC:tb]
is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole
is_a: GO:0089709 ! L-histidine transmembrane transport
is_a: GO:1902024 ! L-histidine transport

[Term]
id: GO:0090514
name: L-tyrosine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-tyrosine into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0015828 ! tyrosine transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0090515
name: L-glutamate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0090454 ! glutamate transmembrane import into vacuole

[Term]
id: GO:0090516
name: L-serine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-serine into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0015825 ! L-serine transport
is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0090517
name: L-lysine transmembrane import into vacuole
namespace: biological_process
alt_id: GO:0090456
def: "The directed movement of L-lysine into the vacuole across the vacuolar membrane." [GOC:al]
synonym: "lysine transmembrane import into vacuole" BROAD []
synonym: "vacuolar lysine import" BROAD [GOC:tb]
is_a: GO:0015819 ! lysine transport
is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole
is_a: GO:1903401 ! L-lysine transmembrane transport

[Term]
id: GO:0090518
name: L-arginine transmembrane import into vacuole
namespace: biological_process
alt_id: GO:0090458
def: "The directed movement of L-arginine into the vacuole across the vacuolar membrane." [GOC:al]
synonym: "arginine transmembrane import into vacuole" BROAD []
synonym: "vacuolar arginine import" EXACT [GOC:tb]
is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole
is_a: GO:1903826 ! L-arginine transmembrane transport

[Term]
id: GO:0090519
name: anoxia protection
namespace: biological_process
def: "Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia." [GOC:tb, PMID:19372430]
is_a: GO:0034059 ! response to anoxia

[Term]
id: GO:0090520
name: sphingolipid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by a sphingolipid." [PMID:9525917]
synonym: "ceramide 1-phosphate signaling pathway" NARROW [PMID:20870412]
synonym: "ceramide signaling pathway" NARROW [PMID:20870412]
synonym: "sphingolipid mediated signal transduction" EXACT [GOC:signaling]
synonym: "sphingolipid signaling pathway" RELATED []
synonym: "sphingolipid-mediated signaling pathway" EXACT [GOC:signaling]
synonym: "sphingosine signaling pathway" NARROW [PMID:20870412]
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0090521
name: podocyte cell migration
namespace: biological_process
def: "The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell." [GOC:pm, PMID:21402783]
synonym: "glomerular visceral epithelial cell migration" EXACT []
is_a: GO:0010631 ! epithelial cell migration

[Term]
id: GO:0090522
name: vesicle tethering involved in exocytosis
namespace: biological_process
def: "The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]
synonym: "vesicle tethering to plasma membrane" NARROW []
is_a: GO:0099022 ! vesicle tethering
is_a: GO:0140029 ! exocytic process

[Term]
id: GO:0090523
name: cytochrome-b5 reductase activity, acting on NADPH
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)." [GOC:tb, RHEA:64576]
synonym: "cytochrome-b5 reductase activity" BROAD []
xref: RHEA:64576
is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H

[Term]
id: GO:0090524
name: cytochrome-b5 reductase activity, acting on NADH
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [GOC:tb]
synonym: "cytochrome b5 reductase activity" BROAD []
is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H

[Term]
id: GO:0090527
name: obsolete actin filament reorganization
namespace: biological_process
def: "OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments." [GOC:dph, GOC:tb]
comment: This term was obsoleted because it represents the same process as actin filament organization ; GO:0007015.
is_obsolete: true

[Term]
id: GO:0090528
name: smooth septate junction assembly
namespace: biological_process
def: "The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:22854041]
is_a: GO:0019991 ! septate junction assembly

[Term]
id: GO:0090529
name: cell septum assembly
namespace: biological_process
alt_id: GO:0090530
def: "The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cell septum assembly involved in cell cycle cytokinesis" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032506 ! cytokinetic process

[Term]
id: GO:0090531
name: L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose." [GOC:yaf, PMID:11153268]
synonym: "L-ascorbic acid biosynthesis via GDP-alpha-D-mannose" RELATED []
synonym: "Smirnoff-Wheeler's pathway" RELATED []
xref: BioCyc:PWY-882
is_a: GO:0019853 ! L-ascorbic acid biosynthetic process

[Term]
id: GO:0090532
name: L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate." [GOC:yaf, PMID:11153268]
comment: This pathway occurs in most vertebrates, although not in guinea pigs and primates, including humans.
synonym: "L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate" RELATED []
is_a: GO:0019853 ! L-ascorbic acid biosynthetic process

[Term]
id: GO:0090533
name: cation-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:BHF]
is_a: GO:0098533 ! ATPase dependent transmembrane transport complex

[Term]
id: GO:0090534
name: calcium ion-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in)." [GOC:BHF]
is_a: GO:0090533 ! cation-transporting ATPase complex

[Term]
id: GO:0090535
name: WICH complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair." [GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179]
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0090536
name: NoRC complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters." [GOC:krc]
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0090537
name: CERF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters." [GOC:krc]
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0090538
name: peptide pheromone secretion
namespace: biological_process
def: "The regulated release of a peptide pheromone from a cell." [GOC:al, GOC:tb, GOC:vw]
is_a: GO:0000770 ! peptide pheromone export
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0090539
name: peptide pheromone export by transmembrane transport
namespace: biological_process
def: "The directed movement of a peptide pheromone across a membrane and out of a cell." [GOC:al, GOC:tb, GOC:vw]
synonym: "peptide pheromone export by membrane transport" EXACT []
is_a: GO:0000770 ! peptide pheromone export
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0090540
name: bacterial cellulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria." [GOC:yaf, PMID:24097954]
synonym: "bacterial cellulose biosynthesis" EXACT [GOC:yaf]
is_a: GO:0030244 ! cellulose biosynthetic process

[Term]
id: GO:0090541
name: MIT domain binding
namespace: molecular_function
def: "Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking." [GOC:pm, InterPro:IPR007330]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0090542
name: ELYC domain binding
namespace: molecular_function
def: "Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC." [GOC:pm, PMID:18032582, PMID:19525971]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0090543
name: Flemming body
namespace: cellular_component
def: "A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge." [GOC:pm, PMID:18641129, PMID:22522702]
synonym: "Midbody ring" RELATED [PMID:18329369]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030496 ! midbody

[Term]
id: GO:0090545
name: CHD-type complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure." [GOC:krc, GOC:tb, PMID:17350655]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0090546
name: chlorophyll fluorescence
namespace: biological_process
def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light." [PMID:10938857]
is_a: GO:1990066 ! energy quenching

[Term]
id: GO:0090547
name: response to low humidity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere." [GOC:tb]
is_a: GO:0009270 ! response to humidity

[Term]
id: GO:0090548
name: response to nitrate starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate." [GOC:tair_curators]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0090549
name: response to carbon starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source." [GOC:tair_curators, PMID:18245858]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0090550
name: response to molybdenum starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum." [GOC:tair_curators]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0090551
name: response to manganese starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese." [GOC:tair_curators]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0090552
name: unicellular trichome apex
namespace: cellular_component
def: "A cell projection part that is the apical most portion of a unicellular trichome." [GOC:PO_curators, PO:0025537]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0090553
name: unicellular trichome tip
namespace: cellular_component
def: "A cell projection part that is the apical most portion of a unicellular trichome apex." [GOC:PO_curators]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0090552 ! unicellular trichome apex

[Term]
id: GO:0090554
name: phosphatidylcholine floppase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, RHEA:38583]
synonym: "ATP-dependent phosphatidylcholine transporter activity" BROAD []
synonym: "ATPase-coupled phosphatidylcholine transporter activity" BROAD []
synonym: "phosphatidylcholine floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
synonym: "phosphatidylcholine-translocating ATPase activity" BROAD []
xref: RHEA:38583
is_a: GO:0008525 ! phosphatidylcholine transporter activity
is_a: GO:0140328 ! floppase activity

[Term]
id: GO:0090555
name: phosphatidylethanolamine flippase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, PMID:20043909, RHEA:36439]
comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaflet of a membrane).
synonym: "ATP-dependent phosphatidylethanolamine transporter activity" RELATED []
synonym: "ATPase-coupled phosphatidylethanolamine transporter activity" BROAD []
synonym: "phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
synonym: "phosphatidylethanolamine-translocating ATPase activity" RELATED []
xref: RHEA:66132
is_a: GO:0140333 ! glycerophospholipid flippase activity

[Term]
id: GO:0090556
name: phosphatidylserine floppase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, PMID:20224745, RHEA:38567]
synonym: "ATPase-coupled phosphatidylserine transporter activity" BROAD []
synonym: "ATPase-dependent phosphatidylserine transporter activity" BROAD []
synonym: "phosphatidylserine floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
synonym: "phosphatidylserine-translocating ATPase activity" BROAD []
xref: RHEA:38567
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0140328 ! floppase activity

[Term]
id: GO:0090557
name: establishment of endothelial intestinal barrier
namespace: biological_process
def: "The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:krc, PMID:22155109]
is_a: GO:0061028 ! establishment of endothelial barrier

[Term]
id: GO:0090558
name: plant epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0090559
name: regulation of membrane permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0090560
name: 2-(3-amino-3-carboxypropyl)histidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [GOC:pde, PMID:15485916, RHEA:36783]
xref: EC:2.5.1.108
xref: MetaCyc:RXN-11371
xref: Reactome:R-HSA-5358494 "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2"
xref: RHEA:36783
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0090561
name: nuclear migration during mitotic telophase
namespace: biological_process
def: "The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis." [GOC:vw, PMID:23087209]
is_a: GO:0030473 ! nuclear migration along microtubule

[Term]
id: GO:0090562
name: protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119]
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0090563
name: protein-phosphocysteine-sugar phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0090564
name: protein-phosphocysteine-glucose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090565
name: protein-phosphocysteine-mannitol phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090566
name: protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090567
name: reproductive shoot system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure." [GOC:pj]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048367 ! shoot system development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0090570
name: RNA polymerase I transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter." [GOC:tb]
is_a: GO:0017053 ! transcription repressor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0090571
name: RNA polymerase II transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter." [GOC:tb]
is_a: GO:0017053 ! transcription repressor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0090572
name: RNA polymerase III transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter." [GOC:tb]
is_a: GO:0017053 ! transcription repressor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0090573
name: RNA polymerase IV transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter." [GOC:tb]
is_a: GO:0017053 ! transcription repressor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0090574
name: RNA polymerase V transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter." [GOC:tb]
is_a: GO:0017053 ! transcription repressor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0090575
name: RNA polymerase II transcription regulator complex
namespace: cellular_component
def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]
synonym: "RNA polymerase II transcription factor complex" NARROW []
is_a: GO:0005667 ! transcription regulator complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0090576
name: RNA polymerase III transcription regulator complex
namespace: cellular_component
def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III." [GOC:tb]
synonym: "RNA polymerase III transcription factor complex" NARROW []
is_a: GO:0005667 ! transcription regulator complex

[Term]
id: GO:0090577
name: RNA polymerase IV transcription regulator complex
namespace: cellular_component
def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV." [GOC:tb]
synonym: "RNA polymerase IV transcription factor complex" NARROW []
is_a: GO:0005667 ! transcription regulator complex

[Term]
id: GO:0090578
name: RNA polymerase V transcription regulator complex
namespace: cellular_component
def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V." [GOC:tb]
synonym: "RNA polymerase V transcription factor complex" NARROW []
is_a: GO:0005667 ! transcription regulator complex

[Term]
id: GO:0090579
name: obsolete dsDNA loop formation
namespace: biological_process
def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose separated regions on the same dsDNA molecule." [GOC:jh, PMID:15950878]
comment: This term was obsoleted because it was defined like a molecular function.
synonym: "chromatin looping" RELATED [GOC:dph]
synonym: "dsDNA looping" EXACT [GOC:dph]
is_obsolete: true
consider: GO:0140587

[Term]
id: GO:0090580
name: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
namespace: molecular_function
def: "Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand." [GOC:pde, GOC:rb, PMID:11238902]
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0090581
name: protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)." [PMID:14645248]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090582
name: protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)." [PMID:8626640]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090583
name: protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)." [PMID:8875915]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090584
name: protein-phosphocysteine-galactitol-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)." [PMID:8955298]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090585
name: protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)." [PMID:15153772]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090586
name: protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in)." [PMID:8246840]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090587
name: protein-phosphocysteine-glucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)." [PMID:8246840]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090588
name: protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)." [PMID:15060041]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090589
name: protein-phosphocysteine-trehalose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)." [PMID:7608078]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity

[Term]
id: GO:0090590
name: protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)." [PMID:8246840]
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0090591
name: protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)." [PMID:9864311]
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0090592
name: DNA synthesis involved in DNA replication
namespace: biological_process
def: "Synthesis of DNA that is a part of the process of duplicating one or more molecules of DNA." [GOC:vw]
is_a: GO:0071897 ! DNA biosynthetic process
relationship: part_of GO:0006260 ! DNA replication

[Term]
id: GO:0090593
name: obsolete peptidyl-histidine autophosphorylation
namespace: biological_process
def: "OBSOLETE. The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein." [PMID:15947782, PMID:8962061]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0090594
name: inflammatory response to wounding
namespace: biological_process
def: "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." [GOC:add]
is_a: GO:0006954 ! inflammatory response
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0090595
name: L-lysine N6-acetyltransferase
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-lysine = CoA + H+ + N(6)-acetyl-L-lysine." [RHEA:69476]
synonym: "acetyl-CoA:L-lysine N6-acetyltransferase" EXACT []
xref: EC:2.3.1.306
xref: MetaCyc:LYSACET-RXN
xref: RHEA:69476
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0090596
name: sensory organ morphogenesis
namespace: biological_process
def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0007423 ! sensory organ development

[Term]
id: GO:0090597
name: nematode male tail mating organ morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules." [GOC:kmv, PMID:1782863, PMID:18050419, PMID:7409314]
is_a: GO:0048808 ! male genitalia morphogenesis
is_a: GO:0090596 ! sensory organ morphogenesis

[Term]
id: GO:0090598
name: male anatomical structure morphogenesis
namespace: biological_process
def: "The processes by which anatomical structures that are only present in the male organism are generated and organized." [GOC:kmv, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0090599
name: alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose." [GOC:tb]
xref: Reactome:R-HSA-9036727 "GAA hydrolyzes lysosomal glycogen"
xref: Reactome:R-HSA-9036729 "Defective GAA does not hydrolyze lysosomal glycogen"
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0090600
name: obsolete alpha-1,3-glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose." [GOC:sd, GOC:tb]
comment: This term was obsoleted because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0033919

[Term]
id: GO:0090601
name: enucleation
namespace: biological_process
def: "The process in which nucleated precursor cells lose their nucleus." [GOC:tb]
is_a: GO:0022411 ! cellular component disassembly

[Term]
id: GO:0090602
name: sieve element enucleation
namespace: biological_process
def: "The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded." [GOC:tb, PMID:25081480]
is_a: GO:0090601 ! enucleation
relationship: part_of GO:0090603 ! sieve element differentiation

[Term]
id: GO:0090603
name: sieve element differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a sieve element." [GOC:tb]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0090604
name: surface biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
is_a: GO:0042710 ! biofilm formation

[Term]
id: GO:0090605
name: submerged biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
synonym: "solid substrate biofilm formation" RELATED []
is_a: GO:0042710 ! biofilm formation

[Term]
id: GO:0090606
name: single-species surface biofilm formation
namespace: biological_process
alt_id: GO:0032022
def: "A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface." [GOC:ml]
synonym: "multicellular pellicle formation" RELATED []
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0090604 ! surface biofilm formation

[Term]
id: GO:0090609
name: single-species submerged biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0090605 ! submerged biofilm formation

[Term]
id: GO:0090610
name: bundle sheath cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:tb, PMID:24517883]
is_a: GO:0001708 ! cell fate specification

[Term]
id: GO:0090611
name: ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination." [PMID:22547407]
is_a: GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:0090612
name: cAMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3." [PMID:24074367, RHEA:22908]
synonym: "cyclic adenosine monophosphate deaminase activity" EXACT []
xref: EC:3.5.4.46
xref: RHEA:22908
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0090613
name: 5'-deoxyadenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3." [PMID:23968233, RHEA:42892]
xref: EC:3.5.4.41
xref: RHEA:42892
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0090614
name: 5'-methylthioadenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3." [PMID:23968233, RHEA:25025]
xref: EC:3.5.4.31
xref: RHEA:25025
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0090615
name: mitochondrial mRNA processing
namespace: biological_process
def: "Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs." [GOC:tb, PMID:25181358]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0090616
name: mitochondrial mRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358]
is_a: GO:0000965 ! mitochondrial RNA 3'-end processing
is_a: GO:0031124 ! mRNA 3'-end processing
is_a: GO:0090615 ! mitochondrial mRNA processing

[Term]
id: GO:0090617
name: mitochondrial mRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358]
is_a: GO:0090615 ! mitochondrial mRNA processing

[Term]
id: GO:0090618
name: DNA clamp unloading
namespace: biological_process
def: "The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates." [GOC:rb, PMID:23499004]
synonym: "PCNA unloading" RELATED [GOC:rb, PMID:23499004]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0090619
name: meiotic spindle pole
namespace: cellular_component
def: "Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:ha, PMID:18250200]
is_a: GO:0000922 ! spindle pole
relationship: part_of GO:0072687 ! meiotic spindle

[Term]
id: GO:0090620
name: obsolete APC-Cdc20 complex
namespace: cellular_component
def: "OBSOLETE. An anaphase promoting complex bound to the fizzy family APC activator Cdc20/Slp1 which regulates the metaphase anaphase transition by activating the APC/C to target the anaphase inhibitor securin and promotes sister chromatid separation." [GOC:vw, PMID:10921876]
comment: This term was made obsolete because it is too fine-grained for GO. Consider Complex Portal EBI-1252490, Anaphase-Promoting Complex variant 2 as an alternate term.
synonym: "APC-fizzy complex" EXACT [GOC:vw]
synonym: "APC-Slp1 complex" EXACT [GOC:vw]
synonym: "mitotic anaphase promotic complex" RELATED [GOC:vw]
is_obsolete: true
consider: GO:0005680

[Term]
id: GO:0090621
name: obsolete APC-fizzy-related complex
namespace: cellular_component
def: "OBSOLETE. An anaphase promoting complex bound to the fizzy-related family APC activator FZR1/Cdh1/Srw1 that regulates mitotic exit by activating the APC/C to target mitotic cyclins for destruction during anaphase and telophase. Is also active during G1." [GOC:vw, PMID:10921876]
comment: This term was made obsolete because it is too fine-grained for GO.
synonym: "APC-Hct1/Cdh1 complex" EXACT [GOC:vw]
synonym: "APC-Srw1 complex" EXACT [GOC:vw]
is_obsolete: true
consider: GO:0005680

[Term]
id: GO:0090624
name: endoribonuclease activity, cleaving miRNA-paired mRNA
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970, PMID:19239888]
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0090625
name: siRNA-mediated gene silencing by mRNA destabilization
namespace: biological_process
def: "An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970]
synonym: "gene silencing by mRNA cleavage" BROAD []
synonym: "mRNA cleavage involved in gene silencing by siRNA" EXACT []
synonym: "mRNA destabilization-mediated gene silencing by siRNA" EXACT []
is_a: GO:0061157 ! mRNA destabilization
is_a: GO:0140766 ! siRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0090626
name: plant epidermis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the plant epidermis are generated and organized." [GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0090558 ! plant epidermis development

[Term]
id: GO:0090627
name: plant epidermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell." [GOC:tb]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0090628
name: plant epidermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0090627 ! plant epidermal cell differentiation

[Term]
id: GO:0090629
name: lagging strand initiation
namespace: biological_process
def: "The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started." [GOC:mah, GOC:tb]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006273 ! lagging strand elongation

[Term]
id: GO:0090630
name: activation of GTPase activity
namespace: biological_process
alt_id: GO:0032856
alt_id: GO:0032857
alt_id: GO:0032858
alt_id: GO:0032859
alt_id: GO:0032860
alt_id: GO:0032861
alt_id: GO:0032862
alt_id: GO:0032863
alt_id: GO:0032864
def: "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "activation of ARF GTPase activity" NARROW []
synonym: "activation of Cdc42 GTPase activity" NARROW []
synonym: "activation of Rab GTPase activity" NARROW []
synonym: "activation of Rac GTPase activity" NARROW []
synonym: "activation of Ral GTPase activity" NARROW []
synonym: "activation of Ran GTPase activity" NARROW []
synonym: "activation of Rap GTPase activity" NARROW []
synonym: "activation of Ras GTPase activity" NARROW []
synonym: "activation of Rho GTPase activity" NARROW []
synonym: "ARF GTPase activation" NARROW []
synonym: "Cdc42 GTPase activation" NARROW []
synonym: "Rab GTPase activation" NARROW []
synonym: "Rac GTPase activation" NARROW []
synonym: "Ral GTPase activation" NARROW []
synonym: "Ran GTPase activation" NARROW []
synonym: "Rap GTPase activation" NARROW []
synonym: "Ras GTPase activation" NARROW []
synonym: "Rho GTPase activation" NARROW []
is_a: GO:0043547 ! positive regulation of GTPase activity

[Term]
id: GO:0090632
name: N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411]
synonym: "CMP-Neu5Gc synthetase activity" EXACT []
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0090633
name: keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411]
synonym: "CMP-KDN synthetase activity" EXACT []
synonym: "cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity" EXACT []
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0090634
name: microglial cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a microglial cell." [GOC:BHF, GOC:nc, PMID:19100238]
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0090635
name: extracellular core region of desmosome
namespace: cellular_component
def: "The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner." [PMID:20066089]
synonym: "desmoglea" EXACT [PMID:20066089]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030057 ! desmosome

[Term]
id: GO:0090636
name: outer dense plaque of desmosome
namespace: cellular_component
def: "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030057 ! desmosome

[Term]
id: GO:0090637
name: inner dense plaque of desmosome
namespace: cellular_component
def: "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030057 ! desmosome

[Term]
id: GO:0090638
name: phosphatidylcholine biosynthesis from phosphatidylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations." [MetaCyc:PWY-6825]
xref: MetaCyc:PWY-6825
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0090639
name: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine." [MetaCyc:PWY-6826]
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0090640
name: phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine." [MetaCyc:PWY-7470, PMID:24329598, PMID:27758859]
xref: MetaCyc:PWY-7470
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0090641
name: microsporidian-type endospore
namespace: cellular_component
def: "The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins." [PMID:19457051]
comment: Microsporidian biology uses the term endospore differently than GO:0043593 endospore coat which is for a spore formed inside of another cell. Microsporidian endospore refers to the inner layer of the spore wall itself.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031160 ! spore wall

[Term]
id: GO:0090642
name: microsporidian-type exospore
namespace: cellular_component
def: "The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore." [PMID:19457051, PMID:25363531]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031160 ! spore wall

[Term]
id: GO:0090643
name: inflorescence phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem." [PMID:25352850]
is_a: GO:0060771 ! phyllotactic patterning

[Term]
id: GO:0090644
name: age-related resistance
namespace: biological_process
def: "An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR)." [PMID:17635216, PMID:19694953]
synonym: "adult seedling resistance" NARROW []
synonym: "ARR" EXACT []
synonym: "developmental resistance" BROAD []
synonym: "flowering-induced resistance" NARROW []
synonym: "mature seedling resistance" NARROW []
synonym: "ontogenic resistance" BROAD []
synonym: "senescence-induced resistance" NARROW []
is_a: GO:0032502 ! developmental process
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0090646
name: mitochondrial tRNA processing
namespace: biological_process
def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0090647
name: obsolete modulation of age-related behavioral decline
namespace: biological_process
def: "OBSOLETE. Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:cjm, GOC:kmv, PMID:20523893]
comment: This term was obsoleted because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0090648
name: response to environmental enrichment
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment." [GOC:sl, PMID:23644055, PMID:25934034]
synonym: "response to the introduction of novel objects" NARROW []
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0090649
name: response to oxygen-glucose deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936]
synonym: "response to OGD" EXACT [GOC:sl]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0036293 ! response to decreased oxygen levels

[Term]
id: GO:0090650
name: cellular response to oxygen-glucose deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936]
synonym: "cellular response to OGD" EXACT [GOC:sl]
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0036294 ! cellular response to decreased oxygen levels
is_a: GO:0090649 ! response to oxygen-glucose deprivation

[Term]
id: GO:0090651
name: apical cytoplasm
namespace: cellular_component
def: "The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0090652
name: basolateral cytoplasm
namespace: cellular_component
def: "The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0090653
name: apical recycling endosome
namespace: cellular_component
def: "Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells." [PMID:12669082, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315]
is_a: GO:0055037 ! recycling endosome
relationship: part_of GO:0090651 ! apical cytoplasm

[Term]
id: GO:0090654
name: basolateral recycling endosome
namespace: cellular_component
def: "Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells." [PMID:11389442, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315]
is_a: GO:0055037 ! recycling endosome
relationship: part_of GO:0090652 ! basolateral cytoplasm

[Term]
id: GO:0090655
name: double-stranded/single-stranded junction telomeric DNA binding
namespace: molecular_function
def: "Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang." [GOC:BHF, GOC:BHF_telomere, GOC:bhm, GOC:nc, PMID:21852327]
is_a: GO:0000406 ! double-strand/single-strand DNA junction binding
is_a: GO:0042162 ! telomeric DNA binding

[Term]
id: GO:0090656
name: t-circle formation
namespace: biological_process
def: "A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD)." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100]
synonym: "telomeric circle formation" EXACT []
is_a: GO:0001325 ! formation of extrachromosomal circular DNA
relationship: part_of GO:0090737 ! telomere maintenance via telomere trimming

[Term]
id: GO:0090657
name: telomeric loop disassembly
namespace: biological_process
def: "The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:22579284]
synonym: "T loop disassembly" EXACT []
synonym: "t-loop disassembly" EXACT []
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0090658
name: cone matrix sheath
namespace: cellular_component
def: "A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments." [GOC:mr, PMID:2055688]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0033165 ! interphotoreceptor matrix

[Term]
id: GO:0090659
name: walking behavior
namespace: biological_process
def: "The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:tb]
synonym: "locomotor gait pattern" NARROW []
is_a: GO:0007626 ! locomotory behavior

[Term]
id: GO:0090660
name: cerebrospinal fluid circulation
namespace: biological_process
def: "The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional." [GOC:mgi_curators, PMID:22100360, PMID:24229449]
synonym: "cerebrospinal fluid flow" EXACT []
synonym: "CSF circulation" EXACT []
synonym: "CSF flow" EXACT []
is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0090661
name: box H/ACA telomerase RNP complex
namespace: cellular_component
def: "A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283]
is_a: GO:0072588 ! box H/ACA RNP complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005697 ! telomerase holoenzyme complex

[Term]
id: GO:0090663
name: galanin-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor." [GOC:lb, PMID:25691535]
synonym: "galanin signaling pathway" RELATED []
synonym: "galanin signalling pathway" RELATED []
synonym: "galanin-activated signalling pathway" EXACT []
is_a: GO:0007218 ! neuropeptide signaling pathway

[Term]
id: GO:0090664
name: response to high population density
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area." [GOC:mr, PMID:26439857]
synonym: "response to crowding" EXACT [GOC:mr]
is_a: GO:0006950 ! response to stress
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0090665
name: glycoprotein complex
namespace: cellular_component
def: "A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds." [GOC:pf, PMID:7693675, PMID:8662961]
comment: An example is the Dictyostelium multi protein pspB complex, which is secreted from prespore vesicles and incorporated into the spore coat.
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0090666
name: scaRNA localization to Cajal body
namespace: biological_process
def: "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0090670 ! RNA localization to Cajal body

[Term]
id: GO:0090667
name: cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851]
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus

[Term]
id: GO:0090668
name: endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851]
is_a: GO:0090667 ! cell chemotaxis to vascular endothelial growth factor

[Term]
id: GO:0090669
name: telomerase RNA stabilization
namespace: biological_process
def: "Prevention of degradation of telomerase RNA (TERC) molecules." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
synonym: "TERC stabilization" EXACT []
is_a: GO:0043489 ! RNA stabilization

[Term]
id: GO:0090670
name: RNA localization to Cajal body
namespace: biological_process
def: "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0090685 ! RNA localization to nucleus

[Term]
id: GO:0090671
name: telomerase RNA localization to Cajal body
namespace: biological_process
def: "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0090670 ! RNA localization to Cajal body
is_a: GO:0090672 ! telomerase RNA localization

[Term]
id: GO:0090672
name: telomerase RNA localization
namespace: biological_process
def: "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:0090673
name: endothelial cell-matrix adhesion
namespace: biological_process
def: "The binding of an endothelial cell to the extracellular matrix via adhesion molecules." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962]
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0090674
name: endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "The binding of an endothelial cell to the extracellular matrix via fibronectin." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962]
is_a: GO:0090673 ! endothelial cell-matrix adhesion

[Term]
id: GO:0090675
name: intermicrovillar adhesion
namespace: biological_process
def: "The cell-cell adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin." [GOC:lb, PMID:24725409]
is_a: GO:0034109 ! homotypic cell-cell adhesion
relationship: part_of GO:1904970 ! brush border assembly

[Term]
id: GO:0090676
name: calcium ion transmembrane transport via low voltage-gated calcium channel
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel." [GOC:bf, GOC:PARL, PMID:20371816]
synonym: "generation of T-type calcium current" RELATED []
is_a: GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0090677
name: reversible differentiation
namespace: biological_process
def: "A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another." [GOC:curators]
is_a: GO:0036166 ! phenotypic switching

[Term]
id: GO:0090678
name: cell dedifferentiation involved in phenotypic switching
namespace: biological_process
def: "A cell dedifferentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations." [GOC:curators]
is_a: GO:0043697 ! cell dedifferentiation
relationship: part_of GO:0090677 ! reversible differentiation

[Term]
id: GO:0090679
name: cell differentiation involved in phenotypic switching
namespace: biological_process
def: "A cell differentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations." [GOC:curators]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0090677 ! reversible differentiation

[Term]
id: GO:0090680
name: viral release via disruption of host outer membrane
namespace: biological_process
def: "The dissemination of mature viral particles from a host cell via the destabilization of the cell outer membrane." [PMID:17900620]
synonym: "disruption by virus of host outer membrane" RELATED []
is_a: GO:0044659 ! viral release from host cell by cytolysis

[Term]
id: GO:0090681
name: GPCR taste receptor activity
namespace: molecular_function
def: "A G protein-coupled receptor activity that is responsible for the sense of taste." [GOC:hat, GOC:tb]
synonym: "G-protein coupled taste receptor activity" EXACT []
synonym: "G-protein-coupled taste receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0090682
name: GPCR bitter taste receptor activity
namespace: molecular_function
def: "A G protein-coupled receptor activity that is responsible for the sense of bitter taste." [GOC:hat, GOC:tb]
synonym: "G protein-coupled receptor bitter taste receptor activity" EXACT []
synonym: "G-protein coupled receptor bitter taste receptor activity" EXACT []
is_a: GO:0033038 ! bitter taste receptor activity
is_a: GO:0090681 ! GPCR taste receptor activity

[Term]
id: GO:0090683
name: GPCR sweet taste receptor activity
namespace: molecular_function
def: "A G protein-coupled receptor activity that is responsible for the sense of sweet taste." [GOC:hat, GOC:tb]
synonym: "G-protein coupled receptor sweet taste receptor activity" EXACT []
is_a: GO:0033041 ! sweet taste receptor activity
is_a: GO:0090681 ! GPCR taste receptor activity

[Term]
id: GO:0090684
name: contact chemoreceptor activity
namespace: molecular_function
def: "A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception." [GOC:hat, GOC:tb]
synonym: "contact chemosensation receptor activity" EXACT []
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0090685
name: RNA localization to nucleus
namespace: biological_process
def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931]
synonym: "RNA localisation to nucleus" EXACT [GOC:mah]
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:0090686
name: glycine betaine-activated nonselective monoatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts." [GOC:kmv, PMID:24212673]
synonym: "glycine betaine-activated nonselective monovalent cation channel activity" RELATED []
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0090687
name: activation of meiosis I spindle assembly checkpoint
namespace: biological_process
def: "Any process that starts the inactive process of a meiosis I cell cycle spindle assembly checkpoint." [GOC:mah]
is_a: GO:1905326 ! positive regulation of meiosis I spindle assembly checkpoint

[Term]
id: GO:0090688
name: cleavage furrow rim
namespace: cellular_component
def: "The part of the cleavage furrow closest to the cell surface." [GOC:vw, PMID:27082518]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032154 ! cleavage furrow

[Term]
id: GO:0090689
name: cleavage furrow leading edge
namespace: cellular_component
def: "The 'trough' of the cleavage furrow. This is the part of the cleavage furrow closest to the contractile ring." [GOC:vw, PMID:27082518]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032154 ! cleavage furrow

[Term]
id: GO:0090690
name: obsolete heteroreceptor complex
namespace: cellular_component
def: "OBSOLETE. A receptor complex that consists of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger. The formation of the higher level complex initiates a change in cell function." [GOC:pad, GOC:PARL, PMID:22035699, PMID:24157794]
comment: This term was obsoleted as it was created in error.
is_obsolete: true

[Term]
id: GO:0090691
name: formation of plant organ boundary
namespace: biological_process
def: "The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:tb]
is_a: GO:0048859 ! formation of anatomical boundary

[Term]
id: GO:0090692
name: mitochondrial membrane scission site
namespace: cellular_component
def: "The site on the mitochondrial membrane where the separation of a single continuous mitochondrial membrane into two membranes occurs as a final step in mitochondrial fission." [GOC:bc, GOC:PARL, PMID:26618722]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0090693
name: plant organ senescence
namespace: biological_process
def: "A plant organ developmental process during which a plant dismantles cellular components to reclaim the cellular building blocks and nutrients that have been deposited in the plant organs during growth." [GOC:tb, PMID:17177638, PMID:34938309]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0099402 ! plant organ development

[Term]
id: GO:0090694
name: Scc2-Scc4 cohesin loading complex
namespace: cellular_component
def: "A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA." [GOC:vw, PMID:24291789]
synonym: "Mis4-Ssl3 cohesin loading complex" EXACT [GOC:vw]
is_a: GO:0032116 ! SMC loading complex

[Term]
id: GO:0090695
name: Wpl/Pds5 cohesin loading/unloading complex
namespace: cellular_component
def: "A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA." [GOC:vw, PMID:26687354]
is_a: GO:0032116 ! SMC loading complex

[Term]
id: GO:0090696
name: post-embryonic plant organ development
namespace: biological_process
def: "Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:tb]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0099402 ! plant organ development

[Term]
id: GO:0090697
name: post-embryonic plant organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:tb]
is_a: GO:0090698 ! post-embryonic plant morphogenesis
is_a: GO:1905392 ! plant organ morphogenesis
relationship: part_of GO:0090696 ! post-embryonic plant organ development

[Term]
id: GO:0090698
name: post-embryonic plant morphogenesis
namespace: biological_process
def: "The process, occurring after plant embryonic development, by which anatomical structures are generated and organized." [GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0090700
name: maintenance of plant organ identity
namespace: biological_process
def: "The process in which the identity of a plant organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb, PMID:9090883]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0099402 ! plant organ development

[Term]
id: GO:0090701
name: specification of plant organ identity
namespace: biological_process
def: "The regionalization process in which the identity of a plant organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:1905393 ! plant organ formation

[Term]
id: GO:0090703
name: obsolete triplex DNA unwinding
namespace: biological_process
def: "OBSOLETE. The process by which a three-stranded D-loop DNA is unwound or 'melted'." [PMID:26503245]
comment: This term was made obsolete because it was created in error.
is_obsolete: true

[Term]
id: GO:0090704
name: nicotinate-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP." [GOC:tb, PMID:26116607]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0090705
name: trichome papilla
namespace: cellular_component
def: "A plant cell papilla that is part of a trichome cell." [GOC:tb, PMID:24014871]
comment: Part of trichome cell (PO:0008030).
is_a: GO:0090395 ! plant cell papilla

[Term]
id: GO:0090706
name: specification of plant organ position
namespace: biological_process
def: "The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ." [GOC:tb, PMID:9611175]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:1905392 ! plant organ morphogenesis

[Term]
id: GO:0090707
name: establishment of plant organ orientation
namespace: biological_process
def: "The process that determines the orientation of a plant organ or tissue with reference to an axis." [GOC:tb]
is_a: GO:0048560 ! establishment of anatomical structure orientation
relationship: part_of GO:1905392 ! plant organ morphogenesis

[Term]
id: GO:0090708
name: specification of plant organ axis polarity
namespace: biological_process
def: "The process in which the polarity of a plant organ axis is specified." [GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:1905392 ! plant organ morphogenesis

[Term]
id: GO:0090709
name: regulation of timing of plant organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of plant organ formation at a consistent predetermined time point during development." [GOC:tb]
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:1905428 ! regulation of plant organ formation

[Term]
id: GO:0090710
name: phosphomevalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate." [PMID:24375100, RHEA:40955]
xref: EC:4.1.1.99
xref: MetaCyc:RXN-10067
xref: RHEA:40955
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0090711
name: FMN hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: FMN + H2O = phosphate + riboflavin." [PMID:16183635, RHEA:35587]
synonym: "FMN phosphatase" EXACT [EC:3.1.3.102]
xref: EC:3.1.3.102
xref: MetaCyc:RXN0-5187
xref: RHEA:35587
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0090712
name: basal pole of outer hair cell
namespace: cellular_component
def: "The end of the outer hair cell which receives and transmits neural signals." [GOC:sl, PMID:12845523]
is_a: GO:0060187 ! cell pole

[Term]
id: GO:0090713
name: immunological memory process
namespace: biological_process
def: "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526]
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0090714
name: innate immunity memory response
namespace: biological_process
def: "An immune response mediated by the innate immune system and directed against a previously encountered immunologic stimulus, being quicker and quantitatively better compared with the initial response to that stimulus." [GOC:add, PMID:26086132]
is_a: GO:0045087 ! innate immune response
is_a: GO:0090713 ! immunological memory process

[Term]
id: GO:0090715
name: immunological memory formation process
namespace: biological_process
def: "Any immunological memory process that can contribute to the formation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526]
is_a: GO:0090713 ! immunological memory process

[Term]
id: GO:0090716
name: adaptive immune memory response
namespace: biological_process
def: "An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response." [GOC:add, PMID:26831526]
is_a: GO:0002250 ! adaptive immune response
is_a: GO:0090713 ! immunological memory process

[Term]
id: GO:0090717
name: adaptive immune memory response involving T cells and B cells
namespace: biological_process
def: "An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response." [GOC:add, PMID:26831526]
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0090716 ! adaptive immune memory response

[Term]
id: GO:0090718
name: adaptive immune effector response
namespace: biological_process
def: "An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response." [GOC:add, ISBN:1405196831]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0090719
name: adaptive immune effector response involving T cells and B lineage cells
namespace: biological_process
def: "An adaptive immune effector response involving T cells and B lineage cells. In the case of B lineage cells, the effector cells are the antibody secreting plasma cells whereas for T cells the effector cells may be helper T cells or cytotoxic T cells." [GOC:add, ISBN:1405196831]
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0090718 ! adaptive immune effector response

[Term]
id: GO:0090720
name: primary adaptive immune response
namespace: biological_process
def: "An adaptive immune response against an antigen not previously encountered by immune system." [GOC:add, PMID:26831526]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0090721
name: primary adaptive immune response involving T cells and B cells
namespace: biological_process
def: "An adaptive immune response mediated by naive T or B cells against an antigen not previously encountered by immune system." [GOC:add, PMID:26831526]
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0090720 ! primary adaptive immune response

[Term]
id: GO:0090722
name: receptor-receptor interaction
namespace: molecular_function
def: "The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function." [GOC:dox, GOC:pad, GOC:PARL, PMID:22035699, PMID:24157794]
synonym: "hetero-receptor complex formation" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0090723
name: obsolete growth cone part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a growth cone, the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, GOC:tb]
is_obsolete: true
consider: GO:0030426

[Term]
id: GO:0090724
name: central region of growth cone
namespace: cellular_component
def: "The center of the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, PMID:16260607]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030426 ! growth cone

[Term]
id: GO:0090725
name: peripheral region of growth cone
namespace: cellular_component
def: "The non-central region or periphery of the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, PMID:16260607]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030426 ! growth cone

[Term]
id: GO:0090726
name: cortical dynamic polarity patch
namespace: cellular_component
def: "A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation." [GOC:mah, PMID:23200991]
synonym: "dynamic polarity patch at the cell cortex" EXACT [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0090727
name: positive regulation of brood size
namespace: biological_process
def: "Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz]
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0090728
name: negative regulation of brood size
namespace: biological_process
def: "Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz]
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0090729
name: toxin activity
namespace: molecular_function
alt_id: GO:0050827
def: "Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom." [GOC:pt]
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "toxin receptor binding" EXACT []
xref: Wikipedia:Toxin
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0090730
name: Las1 complex
namespace: cellular_component
def: "A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448)." [GOC:vw, PMID:26638174]
synonym: "Las1-Grc3-Rat1-Rai1" NARROW [GOC:vw]
is_a: GO:1902555 ! endoribonuclease complex
is_a: GO:1902911 ! protein kinase complex
is_a: GO:1905354 ! exoribonuclease complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0090731
name: cellular response to very-low-density lipoprotein particle stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very-low-density lipoprotein particle stimulus." [GOC:aruk, GOC:bc]
synonym: "cellular response to VLDL particle stimulus" EXACT []
is_a: GO:0055094 ! response to lipoprotein particle
is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus

[Term]
id: GO:0090732
name: cofilin-actin rod
namespace: cellular_component
def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and disulfide cross-linked cofilin multimers." [GOC:sl, PMID:22573689, PMID:24760020]
is_a: GO:0031002 ! actin rod

[Term]
id: GO:0090733
name: tenascin complex
namespace: cellular_component
def: "A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R." [GOC:bhm, PMID:11731446, PMID:12845616, PMID:17909022, PMID:23658023]
comment: An example is Tenascin-N (Q9UQP3) in PMID:17909022 (IDA).
synonym: "Tenascin-C" NARROW []
synonym: "Tenascin-N" NARROW []
synonym: "Tenascin-R" NARROW []
synonym: "Tenascin-W" NARROW []
synonym: "Tenascin-X" NARROW []
is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0090734
name: site of DNA damage
namespace: cellular_component
def: "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]
xref: Wikipedia:DNA_repair
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0090735
name: DNA repair complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex." [GOC:pg, PMID:27113759, PMID:27233470]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0090736
name: MATH domain binding
namespace: molecular_function
def: "Binding to a meprin and TRAF homology (MATH) domain." [InterPro:IPR002083, PMID:22621901]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0090737
name: telomere maintenance via telomere trimming
namespace: biological_process
def: "A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:27918544]
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0090740
name: obsolete integral component of pigment granule membrane
namespace: cellular_component
def: "OBSOLETE. The component of the pigment granule membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [PMID:11294610]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0090741

[Term]
id: GO:0090741
name: pigment granule membrane
namespace: cellular_component
def: "Any membrane that is part of a pigment granule." [PMID:11294610]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0048770 ! pigment granule

[Term]
id: GO:0093001
name: glycolysis from storage polysaccharide through glucose-1-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH." [GOC:dph, GOC:glycolysis]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate

[Term]
id: GO:0093002
name: response to nematicide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes." [GOC:kvm, PMID:22301316]
synonym: "response to antihelmintic" EXACT [GOC:kvm]
synonym: "response to nematocide" EXACT [GOC:kvm]
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0095500
name: acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "acetylcholine receptor signalling pathway" EXACT []
is_a: GO:0098926 ! postsynaptic signal transduction
relationship: part_of GO:1905145 ! cellular response to acetylcholine

[Term]
id: GO:0097001
name: ceramide binding
namespace: molecular_function
def: "Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [GOC:sart]
is_a: GO:0033218 ! amide binding
is_a: GO:0046625 ! sphingolipid binding

[Term]
id: GO:0097002
name: mitochondrial inner boundary membrane
namespace: cellular_component
def: "The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane." [GOC:mcc, PMID:16054341, PMID:19019989]
synonym: "inner bounding mitochondrial membrane" EXACT [NIF_Subcellular:sao18461326]
xref: NIF_Subcellular:sao18461326
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0097003
name: adipokinetic hormone receptor activity
namespace: molecular_function
def: "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
synonym: "AKH receptor activity" EXACT []
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0097004
name: adipokinetic hormone binding
namespace: molecular_function
def: "Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
synonym: "AKH binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0097005
name: adipokinetic hormone receptor binding
namespace: molecular_function
def: "Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
synonym: "AKH receptor binding" EXACT []
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0097006
name: regulation of plasma lipoprotein particle levels
namespace: biological_process
def: "Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism." [GOC:BHF]
synonym: "plasma lipoprotein particle homeostasis" NARROW []
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0097007
name: 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone." [GOC:kad, MetaCyc:RXN-8620, PMID:21088219]
synonym: "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity" EXACT []
synonym: "TMTT synthase activity" EXACT []
xref: MetaCyc:RXN-8620
xref: RHEA:13545
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0097008
name: (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone." [GOC:kad, MetaCyc:RXN-8619, PMID:21088219]
synonym: "(3E)-4,8-dimethylnona-1,3,7-triene synthase activity" EXACT []
synonym: "DNMT synthase activity" RELATED []
xref: MetaCyc:RXN-8619
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0097009
name: energy homeostasis
namespace: biological_process
alt_id: GO:2000505
alt_id: GO:2000506
alt_id: GO:2000507
def: "Any process involved in the balance between food intake (energy input) and energy expenditure." [GOC:yaf, PMID:15919751]
synonym: "negative regulation of energy homeostasis" RELATED []
synonym: "positive regulation of energy homeostasis" RELATED []
synonym: "regulation of energy homeostasis" RELATED []
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0097010
name: eukaryotic translation initiation factor 4F complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex." [GOC:BHF, GOC:ebc, PMID:18337562]
synonym: "eIF-4F assembly" EXACT [GOC:pr]
synonym: "eIF4F assembly" EXACT [GOC:pr]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0097011
name: cellular response to granulocyte macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:BHF, GOC:ebc, PMID:7901744]
synonym: "cellular response to GM-CSF stimulus" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0097012 ! response to granulocyte macrophage colony-stimulating factor

[Term]
id: GO:0097012
name: response to granulocyte macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:pr]
synonym: "response to GM-CSF" EXACT []
synonym: "response to granulocyte macrophage colony-stimulating factor stimulus" EXACT [GOC:dos]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0097013
name: phagocytic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs]
is_a: GO:0071682 ! endocytic vesicle lumen
relationship: part_of GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0097014
name: ciliary plasm
namespace: cellular_component
def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm".
synonym: "cilial cytoplasm" RELATED []
synonym: "ciliary cytoplasm" RELATED []
synonym: "cilium cytoplasm" RELATED []
synonym: "cilium plasm" EXACT []
synonym: "microtubule-based flagellar cytoplasm" RELATED []
synonym: "microtubule-based flagellar matrix" NARROW []
synonym: "microtubule-based flagellum cytoplasm" RELATED []
synonym: "microtubule-based flagellum matrix" NARROW []
is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0097015
name: obsolete bacterial-type flagellar cytoplasm
namespace: cellular_component
def: "OBSOLETE. All of the contents of a bacterial-type flagellum, excluding the plasma membrane surrounding the flagellum." [GOC:BHF]
comment: The reason for obsoletion is that this term describes a cellular component that does not exist.
synonym: "bacterial-type flagellum cytoplasm" EXACT []
is_obsolete: true

[Term]
id: GO:0097016
name: L27 domain binding
namespace: molecular_function
def: "Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner." [GOC:BHF, PMID:15241471, PMID:17237226, Prosite:PDOC51022]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0097017
name: renal protein absorption
namespace: biological_process
def: "A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:yaf, PMID:18431508]
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0097018
name: renal albumin absorption
namespace: biological_process
def: "A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron." [GOC:yaf, PMID:18431508]
is_a: GO:0097017 ! renal protein absorption

[Term]
id: GO:0097019
name: obsolete neurotransmitter receptor catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors." [GOC:kmv]
comment: The reason for obsoletion is that 'neurotransmitter' is unnecessary grouping in the metabolism branch of the ontology, and it creates true path violations.
synonym: "neurotransmitter receptor breakdown" EXACT []
synonym: "neurotransmitter receptor catabolism" EXACT []
synonym: "neurotransmitter receptor degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0097020
name: COPII receptor activity
namespace: molecular_function
def: "Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles." [GOC:rb, PMID:16957051, PMID:20236934]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0097021
name: lymphocyte migration into lymphoid organs
namespace: biological_process
def: "The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575]
synonym: "lymphocyte homing" NARROW []
is_a: GO:0072676 ! lymphocyte migration

[Term]
id: GO:0097022
name: lymphocyte migration into lymph node
namespace: biological_process
def: "The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575]
synonym: "lymphocyte homing" EXACT []
is_a: GO:0097021 ! lymphocyte migration into lymphoid organs

[Term]
id: GO:0097023
name: fructose 6-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate." [GOC:imk, PMID:11120740, PMID:21290439]
xref: RHEA:28002
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0097025
name: MPP7-DLG1-LIN7 complex
namespace: cellular_component
def: "A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions." [GOC:BHF, PMID:17237226]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005912 ! adherens junction

[Term]
id: GO:0097026
name: dendritic cell dendrite assembly
namespace: biological_process
def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351]
comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals.
synonym: "dendritic extension" BROAD []
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0097027
name: ubiquitin-protein transferase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity

[Term]
id: GO:0097028
name: dendritic cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr]
comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
is_a: GO:1903131 ! mononuclear cell differentiation

[Term]
id: GO:0097029
name: mature conventional dendritic cell differentiation
namespace: biological_process
def: "The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells." [GOC:BHF, PMID:15845453]
comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:0097030
name: CENP-A containing nucleosome binding
namespace: molecular_function
def: "Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:jp, PMID:21412236]
synonym: "centromere-specific nucleosome binding" RELATED [GOC:vw]
synonym: "centromeric nucleosome binding" RELATED []
is_a: GO:0031491 ! nucleosome binding

[Term]
id: GO:0097031
name: obsolete mitochondrial respiratory chain complex I biogenesis
namespace: biological_process
def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr]
comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation.
is_obsolete: true

[Term]
id: GO:0097032
name: obsolete mitochondrial respiratory chain complex II biogenesis
namespace: biological_process
def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex II, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr]
comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation.
is_obsolete: true

[Term]
id: GO:0097033
name: obsolete mitochondrial respiratory chain complex III biogenesis
namespace: biological_process
def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc]
comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation.
synonym: "mitochondrial cytochrome bc(1) complex biogenesis" EXACT [GOC:pr]
is_obsolete: true

[Term]
id: GO:0097034
name: obsolete mitochondrial respiratory chain complex IV biogenesis
namespace: biological_process
def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase complex), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc]
comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation.
synonym: "mitochondrial cytochrome c oxidase complex biogenesis" EXACT [GOC:pr]
is_obsolete: true

[Term]
id: GO:0097035
name: regulation of membrane lipid distribution
namespace: biological_process
def: "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]
is_a: GO:0061024 ! membrane organization
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0097036
name: regulation of plasma membrane sterol distribution
namespace: biological_process
def: "Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [GOC:mah, PMID:18441123, PMID:20823909]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0097035 ! regulation of membrane lipid distribution

[Term]
id: GO:0097037
name: heme export
namespace: biological_process
def: "The directed movement of heme out of a cell or organelle." [GOC:lf, PMID:15369674, PMID:20610401]
is_a: GO:0015886 ! heme transport

[Term]
id: GO:0097038
name: perinuclear endoplasmic reticulum
namespace: cellular_component
def: "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
synonym: "perinuclear ER" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0048471 ! perinuclear region of cytoplasm

[Term]
id: GO:0097039
name: protein linear polyubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein." [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181, PMID:31998699]
synonym: "M1 linkage" NARROW []
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0097040
name: phthiocerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents." [GOC:dph, GOC:ecd, PMID:9201977]
synonym: "phthiocerol anabolism" EXACT []
synonym: "phthiocerol biosynthesis" EXACT []
synonym: "phthiocerol formation" EXACT []
synonym: "phthiocerol synthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0042845 ! glycol biosynthetic process

[Term]
id: GO:0097041
name: phenolic phthiocerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position." [GOC:dph, GOC:ecd, PMID:9201977]
synonym: "phenolic phthiocerol anabolism" EXACT []
synonym: "phenolic phthiocerol biosynthesis" EXACT []
synonym: "phenolic phthiocerol formation" EXACT []
synonym: "phenolic phthiocerol synthesis" EXACT []
synonym: "phenolphthiocerol biosynthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0097042
name: obsolete extrinsic component of fungal-type vacuolar membrane
namespace: cellular_component
def: "OBSOLETE. The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:jh, PMID:21454883]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "extrinsic to fungal-type vacuolar membrane" NARROW []
is_obsolete: true
consider: GO:0000329

[Term]
id: GO:0097043
name: obsolete histone H3-K56 acetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone." [GOC:bf, GOC:pr]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0097044
name: obsolete histone H3-K56 acetylation in response to DNA damage
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell." [GOC:pr, GOC:vw, PMID:18344406]
comment: This term was obsoleted because it represents a molecular function and a GO-CAM model.
is_obsolete: true
consider: GO:0140861

[Term]
id: GO:0097045
name: phosphatidylserine exposure on blood platelet
namespace: biological_process
def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system." [GOC:bf, GOC:lf, GOC:pr, PMID:21107324]
is_a: GO:0017121 ! plasma membrane phospholipid scrambling
is_a: GO:0030194 ! positive regulation of blood coagulation

[Term]
id: GO:0097046
name: replication fork progression beyond termination site
namespace: biological_process
def: "Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks." [GOC:bf, GOC:mcc, GOC:pr, PMID:20797631]
is_a: GO:2000621 ! regulation of DNA replication termination

[Term]
id: GO:0097047
name: DNA replication termination region
namespace: cellular_component
def: "A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks." [GOC:mcc, GOC:pr, PMID:20797631]
synonym: "TER" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0097048
name: dendritic cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845]
synonym: "dendritic cell apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process

[Term]
id: GO:0097049
name: motor neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086]
synonym: "motoneuron apoptosis" EXACT []
synonym: "motor neuron apoptosis" NARROW []
is_a: GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0097050
name: type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305]
synonym: "pancreatic B cell apoptosis" EXACT []
synonym: "pancreatic beta cell apoptosis" EXACT []
synonym: "type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:0097051
name: establishment of protein localization to endoplasmic reticulum membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the endoplasmic reticulum membrane." [GOC:rb, PMID:9388185]
synonym: "establishment of protein localisation in endoplasmic reticulum membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in endoplasmic reticulum membrane" EXACT []
is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0097052
name: L-kynurenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [GOC:yaf]
synonym: "L-kynurenine metabolism" EXACT []
is_a: GO:0070189 ! kynurenine metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process

[Term]
id: GO:0097053
name: L-kynurenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [GOC:yaf]
synonym: "L-kynurenine breakdown" EXACT []
synonym: "L-kynurenine catabolism" EXACT []
synonym: "L-kynurenine degradation" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0097052 ! L-kynurenine metabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process

[Term]
id: GO:0097054
name: L-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf]
synonym: "L-glutamate anabolism" EXACT []
synonym: "L-glutamate biosynthesis" EXACT []
synonym: "L-glutamate formation" EXACT []
synonym: "L-glutamate synthesis" EXACT []
is_a: GO:0006537 ! glutamate biosynthetic process

[Term]
id: GO:0097055
name: agmatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase." [GOC:pr, GOC:yaf]
synonym: "agmatine anabolism" EXACT []
synonym: "agmatine biosynthesis" EXACT []
synonym: "agmatine formation" EXACT []
synonym: "agmatine synthesis" EXACT []
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0097056
name: obsolete selenocysteinyl-tRNA(Sec) biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine." [GOC:yaf, PMID:15317934]
comment: This term was obsoleted because it is the same process as GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec.
synonym: "selenocysteinyl-tRNA(Sec) anabolism" EXACT []
synonym: "selenocysteinyl-tRNA(Sec) biosynthesis" EXACT []
synonym: "selenocysteinyl-tRNA(Sec) formation" EXACT []
synonym: "selenocysteinyl-tRNA(Sec) synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0001717

[Term]
id: GO:0097057
name: TRAF2-GSTP1 complex
namespace: cellular_component
def: "A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses." [GOC:BHF, PMID:16636664]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097058
name: CRLF-CLCF1 complex
namespace: cellular_component
def: "A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex." [GOC:BHF, PMID:10966616]
synonym: "CLF-CLC complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0097059
name: CNTFR-CLCF1 complex
namespace: cellular_component
def: "A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space." [GOC:BHF, PMID:11285233]
synonym: "sCNTFR-CLC complex" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0097060
name: synaptic membrane
namespace: cellular_component
def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]
subset: goslim_synapse
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0097061
name: dendritic spine organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104]
synonym: "dendritic spine organisation" EXACT []
is_a: GO:0099173 ! postsynapse organization
is_a: GO:0106027 ! neuron projection organization

[Term]
id: GO:0097062
name: dendritic spine maintenance
namespace: biological_process
def: "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104]
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0097061 ! dendritic spine organization

[Term]
id: GO:0097063
name: cadmium ion sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)." [GOC:rs, PMID:19456862]
is_a: GO:0140784 ! metal ion sensor activity

[Term]
id: GO:0097064
name: obsolete ncRNA export from nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm." [GOC:dgf, PMID:11352936]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0006405

[Term]
id: GO:0097065
name: anterior head development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure." [GOC:yaf, PMID:14695376, PMID:15857913]
is_a: GO:0060322 ! head development

[Term]
id: GO:0097066
name: response to thyroid hormone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872]
synonym: "response to thyroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0097067
name: cellular response to thyroid hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0097066 ! response to thyroid hormone

[Term]
id: GO:0097068
name: response to thyroxine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872]
synonym: "response to T4" EXACT [Wikipedia:Thyroxine]
synonym: "response to T4 stimulus" EXACT [Wikipedia:Thyroxine]
synonym: "response to thyroxine stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:0097066 ! response to thyroid hormone
is_a: GO:1901700 ! response to oxygen-containing compound
is_a: GO:1904386 ! response to L-phenylalanine derivative

[Term]
id: GO:0097069
name: cellular response to thyroxine stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872]
synonym: "cellular response to T4 stimulus" EXACT [Wikipedia:Thyroxine]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097067 ! cellular response to thyroid hormone stimulus
is_a: GO:0097068 ! response to thyroxine
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904387 ! cellular response to L-phenylalanine derivative

[Term]
id: GO:0097070
name: ductus arteriosus closure
namespace: biological_process
def: "The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs." [GOC:hw]
is_a: GO:0048844 ! artery morphogenesis

[Term]
id: GO:0097071
name: interferon regulatory factor complex
namespace: cellular_component
def: "A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit." [GOC:cna, PMID:20043992]
synonym: "IRF complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097072
name: interferon regulatory factor 3 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3." [GOC:cna, PMID:12855817, PMID:14556004]
synonym: "IRF3:IRF3 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex

[Term]
id: GO:0097073
name: interferon regulatory factor 5 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5." [GOC:cna, PMID:12138184, PMID:16751392]
synonym: "IRF5:IRF5 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex

[Term]
id: GO:0097074
name: interferon regulatory factor 7 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7." [GOC:cna, PMID:18068231]
synonym: "IRF7:IRF7 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex

[Term]
id: GO:0097075
name: interferon regulatory factor 3-interferon regulatory factor 7 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7." [GOC:cna, PMID:18068231]
synonym: "IRF3:IRF7 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex

[Term]
id: GO:0097076
name: transforming growth factor beta activated kinase 1 complex
namespace: cellular_component
def: "A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits)." [GOC:cna, PMID:16410796, PMID:17496917, PMID:18021073]
synonym: "TAK1 kinase complex" EXACT []
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:0097077
name: copper ion sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)." [GOC:rs, PMID:19928961]
is_a: GO:0140784 ! metal ion sensor activity

[Term]
id: GO:0097078
name: FAL1-SGD1 complex
namespace: cellular_component
def: "A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits." [GOC:rb, PMID:21576267]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097079
name: selenite:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)." [GOC:mcc, PMID:20861301]
synonym: "selenite:H+ symporter activity" EXACT []
synonym: "selenite:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0097080
name: plasma membrane selenite transport
namespace: biological_process
def: "The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane." [GOC:mcc, PMID:20861301]
synonym: "plasma membrane hydrogenselenite transport" EXACT []
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0097081
name: vascular associated smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
synonym: "vascular smooth muscle cell fate commitment" EXACT []
is_a: GO:0042693 ! muscle cell fate commitment
relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation

[Term]
id: GO:0097082
name: vascular associated smooth muscle cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
synonym: "vascular smooth muscle cell fate specification" EXACT []
is_a: GO:0042694 ! muscle cell fate specification
relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment

[Term]
id: GO:0097083
name: vascular associated smooth muscle cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
synonym: "vascular smooth muscle cell fate determination" EXACT []
is_a: GO:0007521 ! muscle cell fate determination
relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment

[Term]
id: GO:0097084
name: vascular associated smooth muscle cell development
namespace: biological_process
def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
synonym: "vascular smooth muscle cell development" EXACT []
is_a: GO:0055001 ! muscle cell development
relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation

[Term]
id: GO:0097085
name: interferon regulatory factor 3-interferon regulatory factor 5 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5." [GOC:cna, PMID:12138184]
synonym: "IRF3:IRF5 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex

[Term]
id: GO:0097086
name: amniotic stem cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone." [CL:0002639, GOC:yaf, PMID:20942606, Wikipedia:Amniotic_stem_cells]
is_a: GO:0072497 ! mesenchymal stem cell differentiation

[Term]
id: GO:0097087
name: interleukin-17A production
namespace: biological_process
alt_id: GO:0150154
def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PMID:27901018]
subset: gocheck_do_not_annotate
synonym: "IL-17A production" EXACT []
synonym: "interleukin-17A biosynthetic process" NARROW []
is_a: GO:0032620 ! interleukin-17 production

[Term]
id: GO:0097088
name: interleukin-17F production
namespace: biological_process
def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, Wikipedia:Interleukin_17]
subset: gocheck_do_not_annotate
synonym: "IL-17F production" EXACT []
is_a: GO:0032620 ! interleukin-17 production

[Term]
id: GO:0097089
name: methyl-branched fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain." [GOC:rs, PMID:19933331]
synonym: "methyl-branched fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0097090
name: presynaptic membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411]
comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
synonym: "pre-synaptic membrane organization" EXACT []
synonym: "presynaptic membrane organisation" EXACT []
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0097091
name: synaptic vesicle clustering
namespace: biological_process
def: "The process that results in grouping synaptic vesicles in presynaptic structures." [GOC:ans, GOC:pr, PMID:19900895, PMID:7568108]
subset: goslim_synapse
is_a: GO:0097479 ! synaptic vesicle localization
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0097092
name: polyacyltrehalose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [GOC:rs, PMID:19729090]
synonym: "polyacyltrehalose metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process

[Term]
id: GO:0097093
name: polyacyltrehalose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [GOC:rs, PMID:19729090]
synonym: "polyacyltrehalose anabolism" EXACT []
synonym: "polyacyltrehalose biosynthesis" EXACT []
synonym: "polyacyltrehalose formation" EXACT []
synonym: "polyacyltrehalose synthesis" EXACT []
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0097092 ! polyacyltrehalose metabolic process

[Term]
id: GO:0097094
name: craniofacial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between cranial and/or facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060349 ! bone morphogenesis
relationship: part_of GO:1904888 ! cranial skeletal system development

[Term]
id: GO:0097095
name: frontonasal suture morphogenesis
namespace: biological_process
def: "The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized." [GOC:pr, GOC:sl, PMID:12416537, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
synonym: "nasofrontal suture morphogenesis" EXACT []
is_a: GO:0097094 ! craniofacial suture morphogenesis

[Term]
id: GO:0097096
name: facial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
is_a: GO:0097094 ! craniofacial suture morphogenesis

[Term]
id: GO:0097097
name: nasal suture morphogenesis
namespace: biological_process
def: "The process in which the nasal suture is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
synonym: "internasal suture morphogenesis" EXACT []
is_a: GO:0097096 ! facial suture morphogenesis

[Term]
id: GO:0097098
name: DNA/RNA hybrid annealing activity
namespace: molecular_function
def: "An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops." [GOC:imk, PMID:21699496]
is_a: GO:0071667 ! DNA/RNA hybrid binding
is_a: GO:0140666 ! annealing activity

[Term]
id: GO:0097099
name: structural constituent of albumen
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo." [GOC:jj, Wikipedia:Albumen]
synonym: "structural constituent of egg white" EXACT []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0097100
name: supercoiled DNA binding
namespace: molecular_function
def: "Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA." [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil]
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0097101
name: blood vessel endothelial cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [CL:0002139, GOC:dgh, PMID:21521739]
is_a: GO:0060847 ! endothelial cell fate specification
relationship: part_of GO:0060846 ! blood vessel endothelial cell fate commitment

[Term]
id: GO:0097102
name: endothelial tip cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels." [CL:0000704, GOC:dgh, PMID:21521739]
synonym: "angiogenic tip cell fate specification" EXACT []
is_a: GO:0097101 ! blood vessel endothelial cell fate specification
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0097103
name: endothelial stalk cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout." [CL:0002671, GOC:dgh, PMID:21521739]
synonym: "angiogenic stalk cell fate specification" EXACT []
is_a: GO:0097101 ! blood vessel endothelial cell fate specification
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0097104
name: postsynaptic membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692]
subset: goslim_synapse
synonym: "post-synaptic membrane assembly" EXACT []
is_a: GO:0001941 ! postsynaptic membrane organization
is_a: GO:0071709 ! membrane assembly
relationship: part_of GO:0099068 ! postsynapse assembly

[Term]
id: GO:0097105
name: presynaptic membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:15797875, PMID:18550748]
comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
subset: goslim_synapse
synonym: "pre-synaptic membrane assembly" EXACT []
is_a: GO:0071709 ! membrane assembly
is_a: GO:0097090 ! presynaptic membrane organization
relationship: part_of GO:0099054 ! presynapse assembly

[Term]
id: GO:0097106
name: postsynaptic density organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273]
synonym: "post synaptic density organization" EXACT []
synonym: "post-synaptic density organization" EXACT []
synonym: "postsynaptic density organisation" EXACT []
synonym: "PSD organization" EXACT []
is_a: GO:0099084 ! postsynaptic specialization organization

[Term]
id: GO:0097107
name: postsynaptic density assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273]
subset: goslim_synapse
synonym: "post synaptic density assembly" EXACT []
synonym: "post-synaptic density assembly" EXACT []
synonym: "PSD assembly" EXACT []
is_a: GO:0097106 ! postsynaptic density organization
is_a: GO:0098698 ! postsynaptic specialization assembly
relationship: part_of GO:1904861 ! excitatory synapse assembly

[Term]
id: GO:0097108
name: hedgehog family protein binding
namespace: molecular_function
def: "Binding to a member of the hedgehog protein family, signaling proteins involved in development." [GOC:BHF, GOC:pr, PMID:10050855]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0097109
name: neuroligin family protein binding
namespace: molecular_function
def: "Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation." [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0097110
name: scaffold protein binding
namespace: molecular_function
def: "Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0097111
name: endoplasmic reticulum-Golgi intermediate compartment organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment." [GOC:br, PMID:18287528]
synonym: "endoplasmic reticulum-Golgi intermediate compartment organisation" EXACT []
synonym: "endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis" RELATED []
synonym: "ER-Golgi intermediate compartment organization" EXACT []
synonym: "ERGIC organization" EXACT []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0097112
name: gamma-aminobutyric acid receptor clustering
namespace: biological_process
def: "The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359]
synonym: "GABA receptor clustering" EXACT []
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:0097113
name: AMPA glutamate receptor clustering
namespace: biological_process
def: "The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785]
synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT []
synonym: "AMPA receptor clustering" EXACT []
is_a: GO:0097688 ! glutamate receptor clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:0097114
name: NMDA glutamate receptor clustering
namespace: biological_process
def: "The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359]
synonym: "N-methyl-D-aspartate receptor clustering" EXACT []
synonym: "NMDA receptor clustering" EXACT []
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:0097115
name: neurexin clustering involved in presynaptic membrane assembly
namespace: biological_process
def: "The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals." [GOC:BHF, GOC:sjp, PMID:12796785]
synonym: "neurexin clustering" BROAD []
synonym: "Nrxn clustering" BROAD []
synonym: "presynaptic neurexin clustering" EXACT []
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0097105 ! presynaptic membrane assembly

[Term]
id: GO:0097116
name: gephyrin clustering involved in postsynaptic density assembly
namespace: biological_process
def: "The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses." [GOC:BHF, GOC:sjp, PMID:15620359, PMID:24552784, PMID:25772192]
synonym: "Geph clustering" BROAD []
is_a: GO:0035418 ! protein localization to synapse
relationship: part_of GO:0097107 ! postsynaptic density assembly

[Term]
id: GO:0097117
name: guanylate kinase-associated protein clustering
namespace: biological_process
def: "The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons." [GOC:BHF, GOC:sjp, PMID:15620359]
synonym: "GKAP clustering" EXACT []
is_a: GO:0072657 ! protein localization to membrane
relationship: part_of GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:0097118
name: neuroligin clustering involved in postsynaptic membrane assembly
namespace: biological_process
def: "The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons." [GOC:BHF, GOC:sjp, PMID:12796785]
synonym: "neuroligin clustering" BROAD []
synonym: "Nlgn clustering" BROAD []
synonym: "postsynaptic neuroligin clustering" EXACT []
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0097104 ! postsynaptic membrane assembly

[Term]
id: GO:0097119
name: postsynaptic density protein 95 clustering
namespace: biological_process
def: "The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins." [GOC:BHF, GOC:sjp, PMID:10433269]
synonym: "Dlg4 clustering" EXACT []
synonym: "post-synaptic density protein 95 clustering" EXACT []
synonym: "PSD-95 clustering" EXACT []
is_a: GO:0072657 ! protein localization to membrane
relationship: part_of GO:0001941 ! postsynaptic membrane organization
relationship: part_of GO:0097106 ! postsynaptic density organization

[Term]
id: GO:0097120
name: receptor localization to synapse
namespace: biological_process
def: "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, GOC:sjp, PMID:21525273]
synonym: "receptor localisation to synapse" EXACT []
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0097121
name: cyclin A1-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097122
name: cyclin A2-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097123
name: cyclin A1-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097124
name: cyclin A2-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097125
name: cyclin B1-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097126
name: cyclin B2-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097127
name: cyclin B3-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097128
name: cyclin D1-CDK4 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097129
name: cyclin D2-CDK4 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097130
name: cyclin D3-CDK4 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097131
name: cyclin D1-CDK6 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097132
name: cyclin D2-CDK6 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097133
name: cyclin D3-CDK6 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097134
name: cyclin E1-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097135
name: cyclin E2-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0097136
name: Bcl-2 family protein complex
namespace: cellular_component
def: "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097137
name: BAD-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097138
name: BAD-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097139
name: BID-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097140
name: BIM-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097141
name: BIM-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097142
name: PUMA-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097143
name: PUMA-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097144
name: BAX complex
namespace: cellular_component
def: "An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097145
name: BAK complex
namespace: cellular_component
def: "An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097146
name: NOXA-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097147
name: NOXA-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097148
name: BCL-2 complex
namespace: cellular_component
def: "A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex

[Term]
id: GO:0097149
name: centralspindlin complex
namespace: cellular_component
def: "A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals)." [GOC:ans, PMID:11782313, PMID:16236794]
is_a: GO:0140535 ! intracellular protein-containing complex
relationship: part_of GO:0072686 ! mitotic spindle

[Term]
id: GO:0097150
name: neuronal stem cell population maintenance
namespace: biological_process
def: "Any process in by an organism or tissue maintains a population of neuronal stem cells." [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758]
is_a: GO:0019827 ! stem cell population maintenance

[Term]
id: GO:0097151
name: positive regulation of inhibitory postsynaptic potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:BHF, GOC:sjp, PMID:18550748]
synonym: "positive regulation of inhibitory post-synaptic membrane potential" EXACT []
synonym: "positive regulation of IPSP" EXACT []
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0098828 ! modulation of inhibitory postsynaptic potential
relationship: positively_regulates GO:0060080 ! inhibitory postsynaptic potential

[Term]
id: GO:0097152
name: mesenchymal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833]
synonym: "mesenchymal cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0097153
name: obsolete cysteine-type endopeptidase activity involved in apoptotic process
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "caspase activity" BROAD []
synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis]
xref: Reactome:R-HSA-6800797 "The PIDDosome activates CASP2"
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0097154
name: GABAergic neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron." [GOC:kmv, PMID:11517269]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0097155
name: fasciculation of sensory neuron axon
namespace: biological_process
def: "The collection of sensory neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711]
is_a: GO:0007413 ! axonal fasciculation

[Term]
id: GO:0097156
name: fasciculation of motor neuron axon
namespace: biological_process
def: "The collection of motor neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711]
is_a: GO:0007413 ! axonal fasciculation

[Term]
id: GO:0097157
name: pre-mRNA intronic binding
namespace: molecular_function
def: "Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]
synonym: "pre-messenger RNA intronic binding" EXACT []
synonym: "pre-mRNA intron binding" EXACT []
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0097158
name: pre-mRNA intronic pyrimidine-rich binding
namespace: molecular_function
def: "Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624, PMID:16777844]
synonym: "pre-messenger RNA intronic pyrimidine-rich binding" EXACT []
is_a: GO:0097157 ! pre-mRNA intronic binding

[Term]
id: GO:0097159
name: organic cyclic compound binding
namespace: molecular_function
def: "Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]
xref: Reactome:R-HSA-1497796 "BH2 binding can lead to eNOS uncoupling"
is_a: GO:0005488 ! binding

[Term]
id: GO:0097160
name: polychlorinated biphenyl binding
namespace: molecular_function
def: "Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings." [GOC:sjw, PMID:7583672]
synonym: "PCB binding" EXACT []
synonym: "polychlorobiphenyl binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0097161
name: DH domain binding
namespace: molecular_function
def: "Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket." [GOC:yaf, InterPro:IPR000219, PMID:12775584]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0097162
name: MADS box domain binding
namespace: molecular_function
def: "Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs." [GOC:yaf, InterPro:IPR002100, PMID:18296735, Wikipedia:MADS-box]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0097163
name: sulfur carrier activity
namespace: molecular_function
def: "Covalently binding to sulfur and delivering it to an acceptor molecule." [GOC:imk, PMID:16387657]
is_a: GO:0140104 ! molecular carrier activity

[Term]
id: GO:0097164
name: ammonium ion metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the ammonium ion." [GOC:dhl, GOC:tb, PMID:14671018]
synonym: "ammonium ion metabolism" EXACT []
synonym: "ammonium metabolic process" RELATED []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0097165
name: nuclear stress granule
namespace: cellular_component
def: "A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:10359787, PMID:12865437]
is_a: GO:0035770 ! ribonucleoprotein granule
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0097166
name: lens epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [CL:0002224, GOC:yaf, PMID:18423449, Wikipedia:Lens_%28anatomy%29#Lens_epithelium]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0002088 ! lens development in camera-type eye

[Term]
id: GO:0097167
name: circadian regulation of translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours." [GOC:ans, PMID:17264215]
synonym: "regulation of mRNA translation in response to circadian clock" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0097168
name: mesenchymal stem cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0000134, GOC:yaf, PMID:20626275]
synonym: "MSC proliferation" EXACT []
is_a: GO:0072089 ! stem cell proliferation

[Term]
id: GO:0097169
name: AIM2 inflammasome complex
namespace: cellular_component
def: "An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA." [GOC:vp, PMID:20303873]
is_a: GO:0061702 ! canonical inflammasome complex

[Term]
id: GO:0097170
name: ADP-L-glycero-beta-D-manno-heptose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [GOC:yaf]
synonym: "ADP-L-glycero-beta-D-manno-heptose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0097171
name: ADP-L-glycero-beta-D-manno-heptose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [GOC:yaf, PMID:11751812]
synonym: "ADP-L-glycero-beta-D-manno-heptose anabolism" EXACT []
synonym: "ADP-L-glycero-beta-D-manno-heptose biosynthesis" EXACT []
synonym: "ADP-L-glycero-beta-D-manno-heptose formation" EXACT []
synonym: "ADP-L-glycero-beta-D-manno-heptose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0097170 ! ADP-L-glycero-beta-D-manno-heptose metabolic process

[Term]
id: GO:0097172
name: N-acetylmuramic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [GOC:yaf]
synonym: "N-acetylmuramate metabolic process" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramate metabolism" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramic acid metabolism" EXACT [PubChem_Compound:5462244]
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0097173
name: N-acetylmuramic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [GOC:yaf]
synonym: "N-acetylmuramate breakdown" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramate catabolic process" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramate catabolism" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramate degradation" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramic acid breakdown" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramic acid catabolism" EXACT [PubChem_Compound:5462244]
synonym: "N-acetylmuramic acid degradation" EXACT [PubChem_Compound:5462244]
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0097172 ! N-acetylmuramic acid metabolic process

[Term]
id: GO:0097174
name: 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [GOC:yaf, PMID:15901686]
synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolic process" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolism" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid metabolism" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid metabolic process" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0097175
name: 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [GOC:yaf, PMID:15901686]
synonym: "1,6-anhydro-N-acetyl-beta-muramate breakdown" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolic process" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolism" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate degradation" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid breakdown" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid catabolism" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid degradation" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate breakdown" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate catabolic process" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate catabolism" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate degradation" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid breakdown" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid catabolic process" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid catabolism" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid degradation" EXACT []
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0097174 ! 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process

[Term]
id: GO:0097176
name: epoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [GOC:rs, PMID:15822179]
synonym: "epoxide metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:0097177
name: mitochondrial ribosome binding
namespace: molecular_function
def: "Binding to a mitochondrial ribosome." [GOC:ans, PMID:20739282]
is_a: GO:0043022 ! ribosome binding

[Term]
id: GO:0097178
name: ruffle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42." [GOC:yaf, PMID:12556481, Wikipedia:Membrane_ruffling]
synonym: "membrane ruffle formation" EXACT []
synonym: "membrane ruffling" EXACT []
xref: Wikipedia:Membrane_ruffling
is_a: GO:0031529 ! ruffle organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0097179
name: protease inhibitor complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity." [GOC:ans, PMID:6323392]
synonym: "peptidase inhibitor complex" BROAD []
is_a: GO:1904090 ! peptidase inhibitor complex

[Term]
id: GO:0097180
name: serine protease inhibitor complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity." [GOC:ans, PMID:6323392]
synonym: "serine-type endopeptidase inhibitor complex" EXACT [GOC:bf, GOC:pr]
synonym: "serpin complex" EXACT []
is_a: GO:0097179 ! protease inhibitor complex

[Term]
id: GO:0097181
name: protein C inhibitor-coagulation factor V complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V." [GOC:ans, PMID:6323392]
synonym: "PCI-coagulation factor V complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-coagulation factor V complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-F5 complex" EXACT [PR:000007300]
synonym: "serpin A5-coagulation factor V complex" EXACT [PR:000014685]
synonym: "SERPINA5-coagulation factor V complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0097182
name: protein C inhibitor-coagulation factor Xa complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa." [GOC:ans, PMID:6323392]
synonym: "PCI-coagulation factor Xa complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-coagulation factor Xa complex" EXACT [PR:000014685]
synonym: "serpin A5-coagulation factor Xa complex" EXACT [PR:000014685]
synonym: "SERPINA5-coagulation factor Xa complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0097183
name: protein C inhibitor-coagulation factor XI complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI." [GOC:ans, PMID:2844223]
synonym: "PCI-coagulation factor XI complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-coagulation factor XI complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-F11 complex" EXACT [PR:000007295]
synonym: "serpin A5-coagulation factor XI complex" EXACT [PR:000014685]
synonym: "SERPINA5-coagulation factor XI complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex

[Term]
id: GO:0097184
name: response to azide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [GOC:yaf, PMID:16846222]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0097185
name: cellular response to azide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [GOC:yaf, PMID:16846222]
is_a: GO:0097184 ! response to azide
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:0097186
name: amelogenesis
namespace: biological_process
def: "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
synonym: "enamel development" EXACT []
is_a: GO:0042475 ! odontogenesis of dentin-containing tooth
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0097187
name: dentinogenesis
namespace: biological_process
def: "The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
synonym: "dentin development" EXACT []
synonym: "dentine development" EXACT []
is_a: GO:0042475 ! odontogenesis of dentin-containing tooth
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0097188
name: dentin mineralization
namespace: biological_process
def: "The process in which calcium salts are deposited into the calcareous tooth structure known as dentin." [GOC:sl, PMID:10206335, PMID:21196346]
synonym: "dentine mineralization" EXACT []
is_a: GO:0034505 ! tooth mineralization
relationship: part_of GO:0097187 ! dentinogenesis

[Term]
id: GO:0097189
name: apoptotic body
namespace: cellular_component
def: "A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um." [GOC:mtg_apoptosis, GOC:vesicles, PMID:15242875, PMID:24223256, Wikipedia:Apoptosis, Wikipedia:Bleb_(cell_biology)]
synonym: "apoptotic bleb" RELATED [GOC:vesicles]
synonym: "apoptotic vesicle" EXACT [GOC:vesicles]
is_a: GO:1903561 ! extracellular vesicle

[Term]
id: GO:0097190
name: apoptotic signaling pathway
namespace: biological_process
alt_id: GO:0008624
def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
synonym: "apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "induction of apoptosis by extracellular signals" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0006915 ! apoptotic process

[Term]
id: GO:0097191
name: extrinsic apoptotic signaling pathway
namespace: biological_process
def: "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
synonym: "death receptor-mediated apoptosis" NARROW []
synonym: "extrinsic apoptosis" NARROW []
synonym: "extrinsic apoptotic pathway" EXACT []
synonym: "extrinsic apoptotic signaling pathway in presence of ligand" NARROW []
synonym: "extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0097192
name: extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]
comment: For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154).
synonym: "dependence receptor signaling pathway" RELATED []
synonym: "extrinsic apoptosis in absence of ligand" NARROW []
synonym: "extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:0038034 ! signal transduction in absence of ligand
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:0097193
name: intrinsic apoptotic signaling pathway
namespace: biological_process
alt_id: GO:0008629
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]
comment: The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
synonym: "induction of apoptosis by intracellular signals" RELATED []
synonym: "intrinsic apoptosis" NARROW []
synonym: "intrinsic apoptotic pathway" EXACT []
synonym: "intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "mitochondrial-mediated apoptotic pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction
is_a: GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0097194
name: execution phase of apoptosis
namespace: biological_process
def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595]
synonym: "apoptosis" NARROW []
synonym: "execution phase of apoptotic process" EXACT []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0006915 ! apoptotic process

[Term]
id: GO:0097195
name: pilomotor reflex
namespace: biological_process
def: "The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect." [GOC:BHF, PMID:21335239, Wikipedia:Pilomotor_reflex]
synonym: "goosebump reflex" EXACT []
synonym: "horripilation" EXACT []
synonym: "piloerection" EXACT []
is_a: GO:0060004 ! reflex

[Term]
id: GO:0097196
name: Shu complex
namespace: cellular_component
def: "A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p." [GOC:jh, PMID:15654096, PMID:19496932]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097197
name: tetraspanin-enriched microdomain
namespace: cellular_component
def: "A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities." [GOC:ans, PMID:19709882, PMID:21930792]
synonym: "membrane tetraspanin-enriched microdomain" EXACT []
synonym: "TEM" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0097198
name: obsolete histone H3-K36 trimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0097199
name: obsolete cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway." [GOC:mtg_apoptosis, PMID:11717445, Wikipedia:Caspase]
comment: Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases.\nThe reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activator caspase activity" NARROW []
synonym: "apical caspase activity" NARROW []
synonym: "cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "initiator caspase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0097200
name: obsolete cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis." [GOC:mtg_apoptosis, Wikipedia:Caspase]
comment: Examples of gene products that may be annotated to this term include CASP3, CASP6 and CASP7, also called effector (or executioner) caspases.\nThe reason for obsoletion is that this term represents a GO-CAM model.
synonym: "effector caspase activity" NARROW []
synonym: "executioner caspase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0097201
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:rn, PMID:11027285, PMID:15575969, PMID:16556235, PMID:18086556, PMID:18627600]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:0033554

[Term]
id: GO:0097202
name: activation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810]
comment: This term should be used to annotate gene products within the context of cellular processes other than apoptotic cell death (e.g., cell cycle arrest). To annotate gene products involved in activation of cysteine-type endopeptidases where the activation results in apoptotic process, please use the more granular term GO:0006919.
subset: gocheck_obsoletion_candidate
synonym: "activation of caspase activity" NARROW []
synonym: "activation of metacaspase activity" RELATED []
is_a: GO:0031638 ! zymogen activation
is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity

[Term]
id: GO:0097203
name: phagocytic cup lip
namespace: cellular_component
def: "The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome." [GOC:pf, PMID:20200225]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0001891 ! phagocytic cup

[Term]
id: GO:0097204
name: phagocytic cup base
namespace: cellular_component
def: "The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking." [GOC:pf, PMID:20200225]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0001891 ! phagocytic cup

[Term]
id: GO:0097205
name: renal filtration
namespace: biological_process
def: "A renal system process in which fluid circulating through the body is filtered through a barrier system." [GOC:pr, GOC:sart]
is_a: GO:0003014 ! renal system process

[Term]
id: GO:0097206
name: nephrocyte filtration
namespace: biological_process
def: "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
is_a: GO:0097205 ! renal filtration

[Term]
id: GO:0097207
name: bud dormancy process
namespace: biological_process
def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud." [GOC:PO_curators, PO_REF:00009]
comment: Bud dormancy may precede dormancy of the whole plant.
synonym: "bud dormancy" RELATED []
is_a: GO:0022611 ! dormancy process
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0097208
name: alveolar lamellar body
namespace: cellular_component
def: "A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:cjm, Wikipedia:Lamellar_granule]
is_a: GO:0042599 ! lamellar body

[Term]
id: GO:0097209
name: epidermal lamellar body
namespace: cellular_component
def: "A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:cjm, Wikipedia:Lamellar_granule]
is_a: GO:0042599 ! lamellar body

[Term]
id: GO:0097210
name: response to gonadotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007]
synonym: "response to GnRH" EXACT []
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0097211
name: cellular response to gonadotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007]
synonym: "cellular response to GnRH" EXACT []
synonym: "cellular response to gonadotrophin-releasing hormone" EXACT [GOC:dph]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:0097210 ! response to gonadotropin-releasing hormone

[Term]
id: GO:0097212
name: lysosomal membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:yaf, PMID:20544854]
synonym: "lysosomal membrane organisation" EXACT [GOC:mah]
synonym: "lysosome membrane organization" EXACT []
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0007040 ! lysosome organization

[Term]
id: GO:0097213
name: regulation of lysosomal membrane permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854]
synonym: "regulation of lysosome membrane permeability" EXACT []
is_a: GO:0090559 ! regulation of membrane permeability
is_a: GO:0097212 ! lysosomal membrane organization

[Term]
id: GO:0097214
name: positive regulation of lysosomal membrane permeability
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854]
synonym: "positive regulation of lysosome membrane permeability" EXACT []
is_a: GO:0097213 ! regulation of lysosomal membrane permeability
is_a: GO:1905710 ! positive regulation of membrane permeability

[Term]
id: GO:0097215
name: negative regulation of lysosomal membrane permeability
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854]
synonym: "negative regulation of lysosome membrane permeability" EXACT []
is_a: GO:0097213 ! regulation of lysosomal membrane permeability
is_a: GO:1905709 ! negative regulation of membrane permeability

[Term]
id: GO:0097216
name: guanosine tetraphosphate binding
namespace: molecular_function
def: "Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions." [GOC:imk, PMID:15109491, PMID:16968770, PMID:18359660]
synonym: "5'-ppGpp-3' binding" EXACT []
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0097217
name: sieve area
namespace: cellular_component
def: "A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements." [ISBN:0471738433, POC:curators]
comment: Part of a sieve element (PO:0025406).
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009505 ! plant-type cell wall

[Term]
id: GO:0097218
name: sieve plate
namespace: cellular_component
def: "A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas." [ISBN:0471738433, POC:curators]
comment: Typical of angiosperms. Part of sieve tube member (PO:0000289).
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009505 ! plant-type cell wall

[Term]
id: GO:0097219
name: compound sieve plate
namespace: cellular_component
def: "A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement." [ISBN:0471738433, POC:curators]
comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell.
is_a: GO:0097218 ! sieve plate

[Term]
id: GO:0097220
name: simple sieve plate
namespace: cellular_component
def: "A sieve plate that contains a single specialized sieve area." [ISBN:0471738433, POC:curators]
comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell.
is_a: GO:0097218 ! sieve plate

[Term]
id: GO:0097221
name: M/G1 phase-specific MADS box-forkhead transcription factor complex
namespace: cellular_component
def: "A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2." [GOC:mah, PMID:18057023]
synonym: "PBF complex" NARROW []
synonym: "PBF transcription complex" NARROW [GOC:vw]
synonym: "PCB binding factor complex" NARROW []
synonym: "pombe cell cycle box binding factor complex" NARROW []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0097222
name: mitochondrial mRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails." [GOC:ans, PMID:18083837]
is_a: GO:0000963 ! mitochondrial RNA processing

[Term]
id: GO:0097223
name: obsolete sperm part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cjm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_obsolete: true

[Term]
id: GO:0097224
name: obsolete sperm connecting piece
namespace: cellular_component
def: "OBSOLETE. The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]
comment: The reason for obsoletion is that this term is equivalent to GO:0120212 sperm head-tail coupling apparatus.
is_obsolete: true
replaced_by: GO:0120212

[Term]
id: GO:0097225
name: sperm midpiece
namespace: cellular_component
def: "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece." [GOC:cjm, MP:0009831]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0036126 ! sperm flagellum

[Term]
id: GO:0097226
name: sperm mitochondrial sheath
namespace: cellular_component
def: "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:cjm, MP:0009832, PMID:32791035]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097225 ! sperm midpiece

[Term]
id: GO:0097227
name: sperm annulus
namespace: cellular_component
def: "The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity." [GOC:cjm, MP:0009834]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0036126 ! sperm flagellum

[Term]
id: GO:0097228
name: sperm principal piece
namespace: cellular_component
def: "The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0036126 ! sperm flagellum

[Term]
id: GO:0097229
name: sperm end piece
namespace: cellular_component
def: "The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane." [GOC:cjm, GOC:sart, MP:0009837]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0036126 ! sperm flagellum

[Term]
id: GO:0097230
name: cell motility in response to potassium ion
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624]
synonym: "K+ facilitation of cell motility" EXACT []
synonym: "potassium ion facilitation of cell motility" EXACT []
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0035865 ! cellular response to potassium ion

[Term]
id: GO:0097231
name: cell motility in response to calcium ion
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624, PMID:8937985]
synonym: "Ca2+ facilitation of cell motility" EXACT []
synonym: "calcium ion facilitation of cell motility" EXACT []
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0071277 ! cellular response to calcium ion

[Term]
id: GO:0097232
name: lamellar body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:sl, PMID:11940594]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042599 ! lamellar body

[Term]
id: GO:0097233
name: alveolar lamellar body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:sl, PMID:11940594]
is_a: GO:0097232 ! lamellar body membrane
relationship: part_of GO:0097208 ! alveolar lamellar body

[Term]
id: GO:0097234
name: epidermal lamellar body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:sl, PMID:11940594]
is_a: GO:0097232 ! lamellar body membrane
relationship: part_of GO:0097209 ! epidermal lamellar body

[Term]
id: GO:0097235
name: obsolete positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:1899286]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0097236
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of zinc ions." [GOC:dgf, PMID:19702872]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0034224
consider: GO:0045944

[Term]
id: GO:0097237
name: cellular response to toxic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr]
is_a: GO:0009636 ! response to toxic substance
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0097238
name: cellular response to methylglyoxal
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:pr]
is_a: GO:0051595 ! response to methylglyoxal
is_a: GO:0110096 ! cellular response to aldehyde
is_a: GO:1901655 ! cellular response to ketone

[Term]
id: GO:0097239
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus." [GOC:dgf, PMID:15773992]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:0097240
name: chromosome attachment to the nuclear envelope
namespace: biological_process
def: "The process in which chromatin is anchored to the nuclear envelope." [GOC:vw, PMID:31635174]
synonym: "attachment of chromatin to nuclear envelope" RELATED []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0050000 ! chromosome localization

[Term]
id: GO:0097241
name: hematopoietic stem cell migration to bone marrow
namespace: biological_process
def: "The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:yaf, PMID:17368745]
synonym: "hematopoietic stem cell homing" BROAD []
synonym: "hemopoietic stem cell migration to bone marrow" EXACT []
synonym: "progenitor cell homing" BROAD []
is_a: GO:0035701 ! hematopoietic stem cell migration

[Term]
id: GO:0097242
name: amyloid-beta clearance
namespace: biological_process
def: "The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors." [GOC:aruk, GOC:bc, GOC:BHF, PMID:18289866, PMID:19098903, PMID:26005850]
synonym: "beta-amyloid clearance" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0097243
name: flavonoid binding
namespace: molecular_function
def: "Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge." [GOC:sl, PMID:20599706]
is_a: GO:0005488 ! binding

[Term]
id: GO:0097244
name: flavonol binding
namespace: molecular_function
def: "Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone." [GOC:sl]
is_a: GO:0043168 ! anion binding
is_a: GO:0097243 ! flavonoid binding

[Term]
id: GO:0097245
name: flavanol binding
namespace: molecular_function
def: "Binding to a flavanol." [GOC:sl]
synonym: "flavan-3-ol binding" NARROW []
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097243 ! flavonoid binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0097246
name: catechin binding
namespace: molecular_function
def: "Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure." [GOC:sl]
is_a: GO:0097245 ! flavanol binding

[Term]
id: GO:0097247
name: epigallocatechin 3-gallate binding
namespace: molecular_function
def: "Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin." [GOC:sl, PMID:21307292]
synonym: "catechin gallate binding" BROAD []
synonym: "EGCG binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097243 ! flavonoid binding

[Term]
id: GO:0097248
name: maintenance of protein location in cell cortex of cell tip
namespace: biological_process
def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell." [GOC:al, PMID:19646873]
is_a: GO:0032065 ! maintenance of protein location in cell cortex

[Term]
id: GO:0097250
name: mitochondrial respirasome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of respiratory enzyme complexes I, III and IV of the mitochondrial inner membrane to form a large supercomplex." [PMID:30030361, PMID:32311046]
synonym: "mitochondrial respiratory chain supercomplex assembly" EXACT []
synonym: "mitochondrial respiratory supercomplex assembly" EXACT []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly

[Term]
id: GO:0097251
name: leukotriene B4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:yaf]
synonym: "leukotriene B4 anabolism" EXACT []
synonym: "leukotriene B4 biosynthesis" EXACT []
synonym: "leukotriene B4 formation" EXACT []
synonym: "leukotriene B4 synthesis" EXACT []
synonym: "LTB4 anabolism" EXACT []
synonym: "LTB4 biosynthesis" EXACT []
synonym: "LTB4 formation" EXACT []
synonym: "LTB4 synthesis" EXACT []
is_a: GO:0019370 ! leukotriene biosynthetic process
is_a: GO:0036102 ! leukotriene B4 metabolic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0097252
name: oligodendrocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520]
synonym: "oligodendrocyte apoptosis" NARROW []
is_a: GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0097253
name: beta-hydroxybutyrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid." [GOC:dsf, PMID:22302940]
synonym: "(R)-3-hydroxybutyrate transmembrane transporter activity" EXACT []
synonym: "3-hydroxybutanoic acid transmembrane transporter activity" EXACT []
is_a: GO:0015245 ! fatty acid transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0097254
name: renal tubular secretion
namespace: biological_process
def: "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion]
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion

[Term]
id: GO:0097255
name: R2TP complex
namespace: cellular_component
def: "A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097256
name: phenyllactate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH." [GOC:pde, PMID:10849007, RHEA:38351]
comment: This enzymatic activity is usually negligible, but may become prominent when phenylalanine levels are abnormally high as in the human disease phenylketonuria (PKU).
xref: RHEA:38351
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0097257
name: leukotriene B4 12-hydroxy dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+." [GOC:mw, KEGG_REACTION:R03864, PMID:8394361, PMID:9461497]
synonym: "leukotriene B4 12-hydroxydehydrogenase activity" EXACT []
xref: Reactome:R-HSA-2161567 "LTB4 is oxidised to 12-oxoLTB4 by PTGR1"
xref: RHEA:50608
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0097258
name: 20-hydroxy-leukotriene B4 omega oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]." [GOC:mw, PMID:2836406, PMID:9675028, RHEA:48668]
synonym: "20-hydroxy-leukotriene B4 omega-oxidase activity" EXACT []
synonym: "20-hydroxy-leukotriene B4 omega-oxidation" RELATED []
xref: Reactome:R-HSA-2161745 "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3"
xref: RHEA:48668
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0097259
name: 20-aldehyde-leukotriene B4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [GOC:mw, PMID:2549038, PMID:2836406, PMID:9675028, RHEA:48672]
xref: Reactome:R-HSA-2161792 "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3"
xref: Reactome:R-HSA-2161979 "20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH"
xref: RHEA:48672
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0097260
name: eoxin A4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene A4 = eoxin A4." [GOC:mw, PMID:18184802, PMID:18647347]
xref: Reactome:R-HSA-2162019 "LTA4 is converted to EXA4 by ALOX15"
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0097261
name: eoxin C4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4." [GOC:mw, PMID:18184802, PMID:18647347]
xref: Reactome:R-HSA-2161768 "EXA4 is converted to EXC4 by LTC4S"
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0097262
name: eoxin D4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid." [GOC:mw, PMID:18184802, PMID:18647347]
xref: Reactome:R-HSA-2161945 "EXC4 is converted to EXD4 by GGT"
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0097263
name: eoxin E4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine." [GOC:mw, PMID:18184802, PMID:18647347]
xref: Reactome:R-HSA-2161868 "EXD4 is converted to EXE4 by DPEP"
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0097264
name: self proteolysis
namespace: biological_process
def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [GOC:yaf, PMID:18676612, PMID:19144634]
synonym: "autolysis" BROAD []
synonym: "self-proteolysis" EXACT []
is_a: GO:0006508 ! proteolysis

[Term]
id: GO:0097265
name: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+." [GOC:mw, PMID:1326548]
synonym: "5(S)-HETE dehydrogenase activity" EXACT []
synonym: "5-HETE dehydrogenase activity" EXACT []
synonym: "5-hydroxy-eicosatetraenoic acid dehydrogenase activity" EXACT []
xref: Reactome:R-HSA-2161776 "5S-HETE is oxidised to 5-oxoETE by 5-HEDH"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0097266
name: phenylacetyl-CoA 1,2-epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+." [EC:1.14.13.149, GOC:bf, GOC:gk, PMID:20660314, PMID:21247899]
synonym: "phenylacetyl-CoA epoxidase activity" EXACT [GOC:bf]
synonym: "phenylacetyl-CoA monooxygenase activity" RELATED [EC:1.14.13.149]
synonym: "ring 1,2-phenylacetyl-CoA epoxidase activity" RELATED [EC:1.14.13.149]
xref: EC:1.14.13.149
xref: KEGG_REACTION:R09838
xref: RHEA:32171
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0097267
name: omega-hydroxylase P450 pathway
namespace: biological_process
def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation." [GOC:mw, PMID:10681399]
synonym: "P450 omega-hydroxylase pathway" EXACT []
is_a: GO:0019369 ! arachidonate metabolic process

[Term]
id: GO:0097268
name: cytoophidium
namespace: cellular_component
def: "A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, PMID:20513629, PMID:21930098, Wikipedia:CTP_synthase#Cytoophidium]
is_a: GO:0099512 ! supramolecular fiber

[Term]
id: GO:0097269
name: all-trans-decaprenyl-diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate." [GOC:mw, PMID:16262699, RHEA:27802]
synonym: "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT []
synonym: "2-trans,6-trans-farnesyl diphosphate activity" EXACT []
synonym: "decaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.91]
synonym: "decaprenyl-diphosphate synthase activity" BROAD [EC:2.5.1.91]
synonym: "polyprenylpyrophosphate synthetase activity" BROAD [EC:2.5.1.91]
synonym: "terpenoidallyltransferase activity" BROAD [EC:2.5.1.91]
synonym: "terpenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.91]
synonym: "trans-prenyltransferase activity" BROAD [EC:2.5.1.91]
xref: EC:2.5.1.91
xref: Reactome:R-HSA-2162253 "PDSS1,2 ligates FPP to IPPP"
xref: RHEA:27802
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0097270
name: dishabituation
namespace: biological_process
def: "The temporary recovery of response to a stimulus when a novel stimulus is added." [GOC:kmv, PMID:11390637, Wikipedia:Habituation]
is_a: GO:0046958 ! nonassociative learning

[Term]
id: GO:0097271
name: protein localization to bud neck
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within a cellular bud neck." [GOC:rb, PMID:22344253]
synonym: "protein localisation to bud neck" EXACT [GOC:mah]
synonym: "protein localization to cellular bud neck" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0097272
name: ammonium homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]
synonym: "ammonia homeostasis" EXACT []
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0097273
name: obsolete creatinine homeostasis
namespace: biological_process
def: "OBSOLETE. Any biological process involved in the maintenance of an internal steady state of creatinine." [GOC:yaf, PMID:12695560]
comment: This term was obsoleted because this process does not exist: creatinine is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
is_obsolete: true
consider: GO:0003014

[Term]
id: GO:0097274
name: obsolete urea homeostasis
namespace: biological_process
def: "OBSOLETE. Any biological process involved in the maintenance of an internal steady state of urea." [GOC:yaf, PMID:12695560]
comment: This term was obsoleted because this process does not exist: urea is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
is_obsolete: true
consider: GO:0003014

[Term]
id: GO:0097275
name: intracellular ammonium homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell." [GOC:yaf, PMID:12695560]
synonym: "cellular ammonia homeostasis" EXACT []
synonym: "cellular ammonium homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis
is_a: GO:0097272 ! ammonium homeostasis

[Term]
id: GO:0097276
name: obsolete cellular creatinine homeostasis
namespace: biological_process
def: "OBSOLETE. Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell." [GOC:yaf, PMID:12695560]
comment: This term was obsoleted because this process does not exist: creatinine is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
is_obsolete: true
consider: GO:0003014

[Term]
id: GO:0097277
name: obsolete cellular urea homeostasis
namespace: biological_process
def: "OBSOLETE. Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell." [GOC:yaf, PMID:12695560]
comment: This term was obsoleted because this process does not exist: urea is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
is_obsolete: true
consider: GO:0003014

[Term]
id: GO:0097278
name: complement-dependent cytotoxicity
namespace: biological_process
def: "Cell killing caused by the membrane attack complex formed following complement activation." [GOC:add, GOC:rv]
is_a: GO:0001906 ! cell killing

[Term]
id: GO:0097279
name: histamine secretion mediated by IgE immunoglobulin
namespace: biological_process
def: "Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen." [GOC:add, GOC:rv]
synonym: "histamine secretion mediated by IgE antibody" EXACT []
synonym: "Ig-mediated histamine release" BROAD []
is_a: GO:0097280 ! histamine secretion mediated by immunoglobulin

[Term]
id: GO:0097280
name: histamine secretion mediated by immunoglobulin
namespace: biological_process
def: "Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface." [GOC:add, GOC:rv, PMID:11490155, PMID:1719184]
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
is_a: GO:0034776 ! response to histamine

[Term]
id: GO:0097281
name: immune complex formation
namespace: biological_process
def: "The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus." [GOC:add, GOC:rv]
synonym: "antibody-mediated agglutination" EXACT []
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0097282
name: immunoglobulin-mediated neutralization
namespace: biological_process
def: "The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin." [GOC:add, GOC:rv]
synonym: "antibody-mediated neutralization" EXACT []
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0097283
name: keratinocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000312, GOC:jc, GOC:mtg_apoptosis, PMID:10201527]
synonym: "keratinocyte apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:0097284
name: hepatocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020]
synonym: "hepatocyte apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:0097285
name: obsolete cell-type specific apoptotic process
namespace: biological_process
def: "OBSOLETE. Any apoptotic process in a specific cell type." [GOC:mtg_apoptosis]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "cell-type specific apoptosis" NARROW []
is_obsolete: true
consider: GO:0006915

[Term]
id: GO:0097287
name: 7-cyano-7-deazaguanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [GOC:yaf, PMID:364423]
synonym: "7-cyano-7-deazaguanine metabolism" EXACT []
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0097288
name: 7-cyano-7-deazaguanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [GOC:yaf, PMID:364423]
synonym: "7-cyano-7-deazaguanine anabolism" EXACT []
synonym: "7-cyano-7-deazaguanine biosynthesis" EXACT []
synonym: "7-cyano-7-deazaguanine formation" EXACT []
synonym: "7-cyano-7-deazaguanine synthesis" EXACT []
is_a: GO:0080028 ! nitrile biosynthetic process
is_a: GO:0097287 ! 7-cyano-7-deazaguanine metabolic process

[Term]
id: GO:0097289
name: alpha-ribazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [GOC:yaf]
synonym: "alpha-ribazole metabolism" EXACT []
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0097290
name: obsolete alpha-ribazole biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [GOC:yaf, MetaCyc:PWY-5508, MetaCyc:PWY-6269, UniPathway:UPA00061]
comment: This term was obsoleted because it represents a molecular function.
synonym: "alpha-ribazole anabolism" EXACT []
synonym: "alpha-ribazole biosynthesis" EXACT []
synonym: "alpha-ribazole formation" EXACT []
synonym: "alpha-ribazole synthesis" EXACT []
is_obsolete: true
consider: GO:0009236
consider: GO:0043755

[Term]
id: GO:0097291
name: renal phosphate ion absorption
namespace: biological_process
def: "A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:lb, PMID:18784102, PMID:22506049]
synonym: "renal phosphate absorption" EXACT []
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0097292
name: XMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving XMP, xanthosine monophosphate." [GOC:yaf]
synonym: "XMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0097293
name: XMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate." [GOC:yaf]
synonym: "XMP anabolism" EXACT []
synonym: "XMP biosynthesis" EXACT []
synonym: "XMP formation" EXACT []
synonym: "XMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0097292 ! XMP metabolic process

[Term]
id: GO:0097294
name: 'de novo' XMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors." [GOC:yaf, PMID:27590927]
synonym: "'de novo' XMP anabolism" EXACT []
synonym: "'de novo' XMP biosynthesis" EXACT []
synonym: "'de novo' XMP formation" EXACT []
synonym: "'de novo' XMP synthesis" EXACT []
is_a: GO:0097293 ! XMP biosynthetic process

[Term]
id: GO:0097295
name: morphine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:yaf, PMID:19567876]
synonym: "morphine anabolism" EXACT []
synonym: "morphine biosynthesis" EXACT []
synonym: "morphine formation" EXACT []
synonym: "morphine synthesis" EXACT []
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:0071272 ! morphine metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:0097296
name: obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway." [GOC:mtg_apoptosis]
comment: Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process.\nThe reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT []
synonym: "activation of initiator caspase activity" NARROW []
is_obsolete: true
replaced_by: GO:2001056

[Term]
id: GO:0097297
name: obsolete activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis." [GOC:mtg_apoptosis]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of effector caspase activity" NARROW []
is_obsolete: true
consider: GO:0016505

[Term]
id: GO:0097298
name: regulation of nucleus size
namespace: biological_process
def: "Any process that modulates the size of the nucleus." [GOC:al, GOC:mah, PMID:19366728]
synonym: "regulation of nuclear size" EXACT []
synonym: "regulation of nuclear volume" EXACT []
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0097299
name: obsolete cysteine-type endopeptidase activity involved in plant-type hypersensitive response
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to plant-type hypersensitive response, the rapid, localized death of plant cells in response to invasion by a pathogen." [GOC:mtg_apoptosis]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "metacaspase activity involved in plant-type hypersensitive response" NARROW []
is_obsolete: true

[Term]
id: GO:0097300
name: programmed necrotic cell death
namespace: biological_process
def: "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:mtg_apoptosis, PMID:21760595]
comment: This term may be used when annotating instances of programmed cell death characterized by necrotic morphology where the involvement of RIPK1 and/or RIPK3 is not shown. See PMID:23818611 for some examples.
synonym: "programmed cell death by necrosis" EXACT []
synonym: "regulated necrosis" BROAD []
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0097301
name: obsolete regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:20412803]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "cellular potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" BROAD []
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:0097302
name: obsolete lipoprotein biosynthetic process via diacylglyceryl transfer
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00664]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "lipoprotein biosynthesis (diacylglyceryl transfer)" EXACT []
is_obsolete: true

[Term]
id: GO:0097303
name: obsolete lipoprotein biosynthetic process via N-acyl transfer
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00666]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "lipoprotein biosynthesis (N-acyl transfer)" EXACT []
is_obsolete: true

[Term]
id: GO:0097304
name: obsolete lipoprotein biosynthetic process via signal peptide cleavage
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00665]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "lipoprotein biosynthesis (signal peptide cleavage)" EXACT []
is_obsolete: true

[Term]
id: GO:0097305
name: response to alcohol
namespace: biological_process
alt_id: GO:1990335
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr, PMID:24014527]
synonym: "process resulting in tolerance to alcohol" NARROW []
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0097306
name: cellular response to alcohol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr]
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0097307
name: response to farnesol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:pr]
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0097308
name: cellular response to farnesol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:di, PMID:11425711]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:0097307 ! response to farnesol

[Term]
id: GO:0097309
name: obsolete cap1 mRNA methylation
namespace: biological_process
def: "OBSOLETE. Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "cap1 mRNA capping" BROAD []
is_obsolete: true
replaced_by: GO:0006370

[Term]
id: GO:0097310
name: obsolete cap2 mRNA methylation
namespace: biological_process
def: "OBSOLETE. Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA." [GOC:sp, PMID:20713356]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "cap2 mRNA capping" BROAD []
is_obsolete: true
replaced_by: GO:0006370

[Term]
id: GO:0097311
name: bacterial biofilm matrix
namespace: cellular_component
def: "A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, PMID:22571672, Wikipedia:Biofilm]
is_a: GO:0062039 ! biofilm matrix

[Term]
id: GO:0097312
name: obsolete bacterial biofilm matrix component
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, PMID:22571672, Wikipedia:Biofilm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "biofilm matrix part" EXACT []
is_obsolete: true
consider: GO:0097311

[Term]
id: GO:0097313
name: bacterial biofilm matrix surface
namespace: cellular_component
def: "The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, PMID:22571672, Wikipedia:Biofilm]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097311 ! bacterial biofilm matrix

[Term]
id: GO:0097314
name: apoptosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process." [GOC:mtg_apoptosis]
synonym: "apoptosome formation" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0097315
name: response to N-acetyl-D-glucosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [GOC:di, PMID:21700702]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0097316
name: cellular response to N-acetyl-D-glucosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [GOC:di, PMID:21700702]
is_a: GO:0097315 ! response to N-acetyl-D-glucosamine
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0097317
name: invasive growth in response to biotic stimulus
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus." [GOC:di, PMID:18679170]
is_a: GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
is_a: GO:0036267 ! invasive filamentous growth

[Term]
id: GO:0097318
name: invasive growth in response to abiotic stimulus
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans." [GOC:di, PMID:18679170]
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0036267 ! invasive filamentous growth

[Term]
id: GO:0097320
name: plasma membrane tubulation
namespace: biological_process
def: "A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]
synonym: "membrane tubulation" BROAD []
synonym: "vesicle scission" RELATED []
is_a: GO:0007009 ! plasma membrane organization

[Term]
id: GO:0097321
name: cell growth mode switching, filamentous to budding
namespace: biological_process
def: "The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans." [GOC:di, PMID:14617167]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0097322
name: 7SK snRNA binding
namespace: molecular_function
def: "Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533]
synonym: "7SK small nuclear RNA binding" EXACT []
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0097323
name: B cell adhesion
namespace: biological_process
def: "The attachment of a B cell to another cell via adhesion molecules." [GOC:jc]
is_a: GO:0007159 ! leukocyte cell-cell adhesion

[Term]
id: GO:0097324
name: melanocyte migration
namespace: biological_process
def: "The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532]
is_a: GO:0010631 ! epithelial cell migration

[Term]
id: GO:0097325
name: melanocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0097326
name: melanocyte adhesion
namespace: biological_process
def: "The attachment of a melanocyte to another cell via adhesion molecules." [CL:0000148, GOC:uh, PMID:22637532]
is_a: GO:0090136 ! epithelial cell-cell adhesion

[Term]
id: GO:0097327
name: response to antineoplastic agent
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms." [GOC:pr]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0097328
name: response to carboplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus." [GOC:pr]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0097329
name: response to antimetabolite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [GOC:pr]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0097330
name: response to 5-fluoro-2'-deoxyuridine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0097331
name: response to cytarabine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1903416 ! response to glycoside

[Term]
id: GO:0097332
name: response to antipsychotic drug
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect." [GOC:pr]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0097333
name: response to olanzapine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0097334
name: response to perphenazine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0097335
name: response to quetiapine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0097336
name: response to risperidone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0097337
name: response to ziprasidone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0097338
name: response to clozapine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus." [GOC:pr]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0097339
name: glycolate transmembrane transport
namespace: biological_process
def: "The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid)." [GOC:am, PMID:11283302, PMID:11785976]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "glycolate membrane transport" EXACT []
is_a: GO:1900866 ! glycolate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0097340
name: inhibition of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739]
subset: gocheck_obsoletion_candidate
synonym: "inhibition of caspase activity" NARROW []
synonym: "prevention of caspase activity" NARROW []
synonym: "prevention of cysteine-type endopeptidase activity" EXACT []
is_a: GO:0097341 ! zymogen inhibition
is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity

[Term]
id: GO:0097341
name: zymogen inhibition
namespace: biological_process
def: "Any process that prevents the proteolytic processing of an inactive enzyme to an active form." [GOC:mtg_apoptosis, PMID:20383739]
synonym: "prevention of zymogen activation" EXACT []
is_a: GO:0010955 ! negative regulation of protein processing

[Term]
id: GO:0097342
name: ripoptosome
namespace: cellular_component
def: "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400]
comment: It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
synonym: "necrosome" RELATED []
synonym: "TNFR1 complex II" NARROW [PMID:22089168]
synonym: "Tnfr1-CII" NARROW [PMID:22089168]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0097343
name: ripoptosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:mtg_apoptosis, PMID:22274400]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0097344
name: obsolete Rix1 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes." [GOC:vw, PMID:14759368, PMID:15260980, PMID:21385875]
comment: redundant, this is the non-catalytic core of Rixosome
synonym: "IPI complex" EXACT []
is_obsolete: true
replaced_by: GO:0120330

[Term]
id: GO:0097345
name: mitochondrial outer membrane permeabilization
namespace: biological_process
def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309]
comment: BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
synonym: "mitochondrial outer membrane permeabilization during apoptotic cell death" BROAD []
synonym: "mitochondrion outer membrane permeabilization" EXACT []
synonym: "MOMP" EXACT []
is_a: GO:1902110 ! positive regulation of mitochondrial membrane permeability involved in apoptotic process
relationship: part_of GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0097346
name: INO80-type complex
namespace: cellular_component
def: "A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0097347
name: TAM protein secretion complex
namespace: cellular_component
def: "A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane." [GOC:am, PMID:22466966]
synonym: "translocation and assembly module protein complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097348
name: host cell endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell endocytic vesicle." [GOC:ecd]
is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane

[Term]
id: GO:0097350
name: neutrophil clearance
namespace: biological_process
def: "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms." [GOC:BHF, PMID:21957127]
is_a: GO:0043277 ! apoptotic cell clearance
relationship: part_of GO:0001780 ! neutrophil homeostasis

[Term]
id: GO:0097351
name: toxin sequestering activity
namespace: molecular_function
def: "Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [GOC:rs, PMID:19143615, PMID:19325885, PMID:21819231, PMID:22545240, PMID:24806488, Wikipedia:Toxin-antitoxin_system#Type_II]
comment: There may be more than one antitoxin to a toxic protein. Instances of this activity are known only in prokaryotes, where the toxic protein may be a ribonuclease, a DNA gyrase, or other.
synonym: "toxin-antitoxin pair type I binding" NARROW []
synonym: "toxin-antitoxin pair type II binding" NARROW []
is_a: GO:0140313 ! molecular sequestering activity

[Term]
id: GO:0097352
name: autophagosome maturation
namespace: biological_process
alt_id: GO:0000046
def: "Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]
synonym: "autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "autophagic vacuole maturation" EXACT [GOC:autophagy]
synonym: "autophagosome fusion" RELATED []
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0097353
name: centrolateral pattern formation
namespace: biological_process
def: "The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment." [GOC:dsz]
synonym: "mediolateral pattern formation" EXACT []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0097354
name: prenylation
namespace: biological_process
def: "The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, PMID:18029206, PMID:21351751, PMID:22123822, PMID:22642693, PMID:22660767]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0097355
name: protein localization to heterochromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah]
synonym: "protein localisation to heterochromatin" EXACT [GOC:mah]
is_a: GO:0071168 ! protein localization to chromatin

[Term]
id: GO:0097356
name: perinucleolar compartment
namespace: cellular_component
def: "The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC." [GOC:vw, PMID:21385875, Wikipedia:Perinucleolar_compartment]
synonym: "perinucleolar region" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0097358
name: D-leucyl-tRNA(Leu) deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Removal of a D-leucine from a charged tRNA(Leu)." [GOC:se, PMID:10918062]
is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity

[Term]
id: GO:0097359
name: UDP-glucosylation
namespace: biological_process
def: "The covalent attachment of a UDP-glucose residue to a substrate molecule." [GOC:al]
is_a: GO:0006011 ! UDP-alpha-D-glucose metabolic process

[Term]
id: GO:0097360
name: chorionic trophoblast cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population." [CL:0011101, GOC:BHF, PMID:15150278]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0097361
name: cytosolic [4Fe-4S] assembly targeting complex
namespace: cellular_component
def: "A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in the cytoplasm and nucleus. In humans it consists of MMS19, CIAO1, CIAO2A/CIAO2B, CIAO3. MMS19, CIAO1 and CIAO2A/CIAO2B form a tight 'core' complex, whereas CIAO3 is an 'external' component of this complex." [PMID:23585563, PMID:23891004, PMID:34660592]
synonym: "CIA complex" BROAD []
synonym: "CIA targeting complex" EXACT [PMID:34660592]
synonym: "cytosolic iron-sulfur protein assembly complex" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990229 ! iron-sulfur cluster assembly complex

[Term]
id: GO:0097362
name: MCM8-MCM9 complex
namespace: cellular_component
def: "A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links." [GOC:sp, PMID:22771115, PMID:22771120]
is_a: GO:0042555 ! MCM complex

[Term]
id: GO:0097363
name: protein O-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]
synonym: "O-GlcNAc transferase" EXACT []
synonym: "O-linked N-acetylglucosaminyltransferase" EXACT []
synonym: "OGTase" EXACT []
synonym: "protein O-GlcNAc transferase activity" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase" EXACT []
xref: EC:2.4.1.255
xref: Reactome:R-HSA-9687828 "O-GlcNAcylation of RIPK3 (TLR4 signaling)"
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0097364
name: stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758]
synonym: "stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential" BROAD []
is_a: GO:0015275 ! stretch-activated, monoatomic cation-selective, calcium channel activity

[Term]
id: GO:0097365
name: stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758]
synonym: "stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential" BROAD []
is_a: GO:0097364 ! stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of action potential

[Term]
id: GO:0097366
name: response to bronchodilator
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to bronchodilator agent" EXACT []
synonym: "response to broncholytic agent" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0097367
name: carbohydrate derivative binding
namespace: molecular_function
def: "Binding to a carbohydrate derivative." [GOC:pr]
subset: goslim_agr
subset: goslim_mouse
is_a: GO:0005488 ! binding

[Term]
id: GO:0097368
name: establishment of Sertoli cell barrier
namespace: biological_process
def: "Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions." [GOC:sl, PMID:19509333, Wikipedia:Blood-testis_barrier]
synonym: "establishment of blood-testis barrier" EXACT []
synonym: "establishment of BTB" EXACT []
synonym: "establishment of SCB" EXACT []
is_a: GO:0060009 ! Sertoli cell development

[Term]
id: GO:0097370
name: protein O-GlcNAcylation via threonine
namespace: biological_process
def: "The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438]
is_a: GO:0018243 ! protein O-linked glycosylation via threonine

[Term]
id: GO:0097371
name: MDM2/MDM4 family protein binding
namespace: molecular_function
def: "Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53." [InterPro:IPR016495]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0097372
name: histone H3K18 deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + NAD+ + H2O = histone H3 L-lysine (position 18) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K18 to NAD, producing nicotinamide." [GOC:sp, PMID:22722849, PMID:28450737]
synonym: "NAD-dependent histone deacetylase activity (H3-K18 specific)" EXACT []
synonym: "NAD-dependent histone H3-K18 deacetylase activity" EXACT []
synonym: "NAD-dependent histone H3K18 deacetylase activity" EXACT []
is_a: GO:0017136 ! histone deacetylase activity, NAD-dependent
is_a: GO:0141050 ! histone H3K deacetylase activity

[Term]
id: GO:0097373
name: MCM core complex
namespace: cellular_component
def: "A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated." [GOC:mah, PMID:10770926, PMID:15007098, PMID:9305914]
synonym: "MCM4/6/7 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097374
name: sensory neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses." [CL:0000101, GOC:pr]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0097375
name: spinal sensory neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord." [CL:0009000, GOC:pr, GOC:yaf]
is_a: GO:0097374 ! sensory neuron axon guidance

[Term]
id: GO:0097376
name: interneuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions." [CL:0000099, GOC:pr]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0097377
name: spinal cord interneuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord." [CL:0005000, GOC:pr]
is_a: GO:0097376 ! interneuron axon guidance

[Term]
id: GO:0097378
name: dorsal spinal cord interneuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord." [GOC:yaf]
synonym: "dorsal interneuron axon guidance" EXACT []
is_a: GO:0097377 ! spinal cord interneuron axon guidance

[Term]
id: GO:0097379
name: dorsal spinal cord interneuron posterior axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367]
synonym: "dorsal interneuron caudal axon projection" RELATED []
is_a: GO:0033564 ! anterior/posterior axon guidance
is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance

[Term]
id: GO:0097380
name: dorsal spinal cord interneuron anterior axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367]
synonym: "dorsal interneuron rostral axon projection" RELATED []
is_a: GO:0033564 ! anterior/posterior axon guidance
is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance

[Term]
id: GO:0097381
name: photoreceptor disc membrane
namespace: cellular_component
def: "Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane." [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0001750 ! photoreceptor outer segment

[Term]
id: GO:0097382
name: obsolete deoxynucleoside-diphosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate." [GOC:pde]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
consider: GO:0017110

[Term]
id: GO:0097383
name: dIDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate." [GOC:pde, PMID:20385596, RHEA:35211]
synonym: "deoxyinosine-diphosphatase activity" RELATED []
xref: Reactome:R-HSA-2509793 "NUDT16 hydrolyses dIDP to dIMP"
xref: RHEA:35211
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0097384
name: obsolete cellular lipid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells." [GOC:pr]
comment: The reason for obsoletion is that this term is redundant to GO:008610
synonym: "cellular lipid anabolism" EXACT []
synonym: "cellular lipid biosynthesis" EXACT []
synonym: "cellular lipid formation" EXACT []
synonym: "cellular lipid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0008610

[Term]
id: GO:0097385
name: programmed necrotic cell death in response to starvation
namespace: biological_process
def: "A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment)." [GOC:mtg_apoptosis, GOC:pg, PMID:13679856]
synonym: "necrotic cell death in response to starvation" BROAD []
is_a: GO:0042594 ! response to starvation
is_a: GO:0097300 ! programmed necrotic cell death

[Term]
id: GO:0097386
name: glial cell projection
namespace: cellular_component
def: "A prolongation or process extending from a glial cell." [GOC:mc]
synonym: "glial process" RELATED []
synonym: "glial projection" RELATED []
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0097387
name: capitate projection
namespace: cellular_component
def: "Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies)." [GOC:mc, PMID:3098431]
is_a: GO:0097386 ! glial cell projection

[Term]
id: GO:0097388
name: chemokine (C-C motif) ligand 19 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL19 production" EXACT []
synonym: "EBI1 ligand chemokine production" EXACT []
synonym: "ELC production" EXACT []
synonym: "macrophage inflammatory protein-3-beta production" EXACT []
synonym: "MIP-3-beta production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0097389
name: chemokine (C-C motif) ligand 21 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL21 production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0097390
name: chemokine (C-X-C motif) ligand 12 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CXCL12 production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0097391
name: chemokine (C-X-C motif) ligand 13 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CXCL13 production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0097392
name: chemokine (C-X-C motif) ligand 16 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CXCL16 production" EXACT []
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0097393
name: telomeric repeat-containing RNA transcription
namespace: biological_process
def: "The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome." [GOC:al, PMID:22139915]
synonym: "TERRA transcription" EXACT [PMID:22139915]
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0097394
name: obsolete telomeric repeat-containing RNA transcription by RNA polymerase II
namespace: biological_process
def: "OBSOLETE. The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter." [GOC:al, PMID:22139915]
comment: This term was obsoleted because there is no evidence that telomeric RNA is specifically transcribed, but it may be a result of cryptic transcription. Biological processes exist to maintain telomeric DNA is a repressed state (subtelomeric heterochromatin formation ; GO:0031509).
synonym: "telomeric repeat-containing RNA transcription from RNA pol II promoter" EXACT []
synonym: "telomeric RNA transcription from Pol II promoter" RELATED []
synonym: "TERRA RNA transcription from RNA pol II promoter" RELATED [GOC:22139915]
is_obsolete: true
consider: GO:0031509

[Term]
id: GO:0097395
name: response to interleukin-32
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr]
synonym: "response to IL-32" EXACT []
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0097396
name: response to interleukin-17
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr]
synonym: "response to IL-17" EXACT []
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0097397
name: cellular response to interleukin-32
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr]
synonym: "cellular response to IL-32" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0097395 ! response to interleukin-32

[Term]
id: GO:0097398
name: cellular response to interleukin-17
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr]
synonym: "cellular response to IL-17" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0097396 ! response to interleukin-17

[Term]
id: GO:0097399
name: interleukin-32-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-32 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493]
synonym: "IL-32-mediated signaling pathway" EXACT []
synonym: "IL-32-mediated signalling pathway" EXACT []
synonym: "interleukin-32-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0097397 ! cellular response to interleukin-32

[Term]
id: GO:0097400
name: interleukin-17-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493]
synonym: "IL-17-mediated signaling pathway" EXACT []
synonym: "IL-17-mediated signalling pathway" EXACT []
synonym: "interleukin-17-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0097398 ! cellular response to interleukin-17

[Term]
id: GO:0097401
name: synaptic vesicle lumen acidification
namespace: biological_process
def: "The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading." [GOC:dsf, PMID:21172605, PMID:22875945]
subset: goslim_synapse
synonym: "synaptic vesicle lumen pH reduction" EXACT []
synonym: "synaptic vesicle proton loading" EXACT syngo_official_label []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0070050 ! neuron cellular homeostasis
is_a: GO:1902600 ! proton transmembrane transport
relationship: part_of GO:0016188 ! synaptic vesicle maturation
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0097402
name: neuroblast migration
namespace: biological_process
def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0097403
name: cellular response to raffinose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:al]
is_a: GO:0071322 ! cellular response to carbohydrate stimulus
is_a: GO:1901545 ! response to raffinose

[Term]
id: GO:0097407
name: Bunina body
namespace: cellular_component
def: "Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles." [NIF_Subcellular:nlx_subcell_20090101, PMID:18026741]
xref: NIF_Subcellular:nlx_subcell_20090101
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097408
name: fibrillary inclusion
namespace: cellular_component
def: "Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra." [NIF_Subcellular:sao967812059]
xref: NIF_Subcellular:sao967812059
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097409
name: glial cytoplasmic inclusion
namespace: cellular_component
def: "Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy." [NIF_Subcellular:nlx_subcell_20090703, PMID:21562886, PMID:2559165]
synonym: "GCI" EXACT []
synonym: "Papp-Lantos body" RELATED []
xref: NIF_Subcellular:nlx_subcell_20090703
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097410
name: hippocampal interneuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron." [CL:1001569, GOC:jc, PMID:19655320]
is_a: GO:0021895 ! cerebral cortex neuron differentiation
relationship: part_of GO:0021766 ! hippocampus development

[Term]
id: GO:0097411
name: hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia." [GOC:bf, GOC:jc, PMID:16887934, PMID:26579469]
synonym: "HIF1alpha pathway" EXACT []
synonym: "hypoxia-inducible factor signaling" EXACT [GOC:bf]
synonym: "hypoxia-inducible factor-1alpha signalling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction
relationship: part_of GO:0071456 ! cellular response to hypoxia

[Term]
id: GO:0097412
name: hyaline inclusion
namespace: cellular_component
def: "A glass-like, pale intracellular inclusion." [NIF_Subcellular:nlx_subcell_20090104]
synonym: "pale body" RELATED []
xref: NIF_Subcellular:nlx_subcell_20090104
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097413
name: Lewy body
namespace: cellular_component
def: "Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein." [NIF_Subcellular:sao4933778419]
synonym: "cytoplasmic inclusion" RELATED []
xref: NIF_Subcellular:sao4933778419
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097414
name: classical Lewy body
namespace: cellular_component
def: "Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils." [NIF_Subcellular:sao4749542545]
synonym: "brainstem Lewy body" RELATED []
xref: NIF_Subcellular:sao4749542545
is_a: GO:0097413 ! Lewy body

[Term]
id: GO:0097415
name: cortical Lewy body
namespace: cellular_component
def: "Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils." [NIF_Subcellular:sao4040591221]
xref: NIF_Subcellular:sao4040591221
is_a: GO:0097413 ! Lewy body

[Term]
id: GO:0097416
name: Lewy body-like hyaline inclusion
namespace: cellular_component
def: "Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments." [NIF_Subcellular:nlx_subcell_20090105, PMID:18026741]
synonym: "LBHI" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090105
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097417
name: nematosome
namespace: cellular_component
def: "Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles." [NIF_Subcellular:sao138430598, PMID:5458990]
xref: NIF_Subcellular:sao138430598
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097418
name: neurofibrillary tangle
namespace: cellular_component
def: "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star." [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926]
comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
synonym: "flame-shaped neurofibrillary tangle" NARROW []
synonym: "star-shaped neurofibrillary tangle" NARROW []
xref: NIF_Subcellular:nlx_subcell_20090201
xref: NIF_Subcellular:nlx_subcell_20090202
xref: NIF_Subcellular:sao2409833926
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097419
name: Pick body
namespace: cellular_component
def: "Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E." [NIF_Subcellular:nlx_subcell_20090102]
xref: NIF_Subcellular:nlx_subcell_20090102
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097420
name: skein-like inclusion
namespace: cellular_component
def: "Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin." [NIF_Subcellular:nlx_subcell_20090103, PMID:18026741]
xref: NIF_Subcellular:nlx_subcell_20090103
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0097421
name: liver regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed liver." [GOC:gap, PMID:19447520]
is_a: GO:0001889 ! liver development
is_a: GO:0031100 ! animal organ regeneration

[Term]
id: GO:0097422
name: tubular endosome
namespace: cellular_component
def: "A network of fine tubules in the vicinity of the Golgi complex and around the centriole." [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161]
synonym: "coated tip" RELATED []
xref: NIF_Subcellular:sao1570660411
xref: NIF_Subcellular:sao694815499
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0097423
name: mitochondrion-associated adherens complex
namespace: cellular_component
def: "An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans." [NIF_Subcellular:sao1933817066, PMID:20089910]
synonym: "MAC" RELATED []
synonym: "mitochondrial adhaerens complex" EXACT []
xref: NIF_Subcellular:sao1933817066
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0097424
name: nucleolus-associated heterochromatin
namespace: cellular_component
def: "Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus." [NIF_Subcellular:sao1210952635]
xref: NIF_Subcellular:sao1210952635
is_a: GO:0030874 ! nucleolar chromatin

[Term]
id: GO:0097425
name: obsolete smooth endoplasmic reticulum part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of the smooth endoplasmic reticulum (also called smooth ER, or SER)." [NIF_Subcellular:sao184202831]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "SER subcomponent" RELATED [NIF_Subcellular:sao1842028314]
xref: NIF_Subcellular:sao184202831
is_obsolete: true
consider: GO:0005790

[Term]
id: GO:0097426
name: glial filament
namespace: cellular_component
def: "An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes." [NIF_Subcellular:sao1863852493]
xref: NIF_Subcellular:sao1863852493
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0097427
name: microtubule bundle
namespace: cellular_component
def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973]
synonym: "microtubule fascicle" EXACT []
xref: NIF_Subcellular:sao1872343973
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0097428
name: protein maturation by iron-sulfur cluster transfer
namespace: biological_process
def: "The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0097429
name: amino acid ligation activity by nonribosomal peptide synthase
namespace: molecular_function
def: "Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase." [GOC:vw]
is_a: GO:0016881 ! acid-amino acid ligase activity
is_a: GO:1904091 ! non-ribosomal peptide synthetase activity

[Term]
id: GO:0097430
name: copper ion import across prospore membrane
namespace: biological_process
def: "The directed movement of copper ions from outside of a cell, across an ascospore-type prospore membrane and into the cytosol." [GOC:al, GOC:vw, PMID:21828039]
synonym: "copper ion import into ascospore-type prospore" RELATED []
synonym: "copper ion transport into forespores" RELATED []
is_a: GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0097431
name: mitotic spindle pole
namespace: cellular_component
def: "Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]
is_a: GO:0000922 ! spindle pole
relationship: part_of GO:0072686 ! mitotic spindle

[Term]
id: GO:0097432
name: hippocampal pyramidal neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus." [CL:1001571, GOC:jc, PMID:19342486]
is_a: GO:0021859 ! pyramidal neuron differentiation
is_a: GO:0021895 ! cerebral cortex neuron differentiation

[Term]
id: GO:0097433
name: dense body
namespace: cellular_component
def: "An electron dense body which may contain granules." [ISBN:0195065719, NIF_Subcellular:sao730872736]
xref: NIF_Subcellular:sao730872736
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0097434
name: succinate:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)." [GOC:al, PMID:1293882]
synonym: "succinate:hydrogen symporter activity" EXACT []
xref: RHEA:29303
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0097435
name: supramolecular fiber organization
namespace: biological_process
alt_id: GO:0043206
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]
synonym: "extracellular fibril organisation" NARROW []
synonym: "extracellular fibril organization" NARROW []
synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah]
synonym: "fibril organisation" RELATED []
synonym: "fibril organization" RELATED []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0097436
name: entry into dormancy
namespace: biological_process
def: "The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009]
synonym: "induction of dormancy" EXACT []
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0097437
name: maintenance of dormancy
namespace: biological_process
def: "The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009]
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0097438
name: exit from dormancy
namespace: biological_process
def: "The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009]
synonym: "release from dormancy" EXACT []
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0097439
name: acquisition of desiccation tolerance
namespace: biological_process
def: "The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state." [GOC:PO_curators]
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0097440
name: apical dendrite
namespace: cellular_component
def: "A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon." [NIF_Subcellular:sao273773228]
xref: NIF_Subcellular:sao273773228
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0097441
name: basal dendrite
namespace: cellular_component
def: "A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon." [GOC:aruk, GOC:bc, NIF_Subcellular:sao1079900774, PMID:17046728, PMID:22683681]
synonym: "basilar dendrite" EXACT [NIF_Subcellular:sao1079900774]
xref: NIF_Subcellular:sao1079900774
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0097442
name: CA3 pyramidal cell dendrite
namespace: cellular_component
def: "A dendrite of a hippocampal CA3 pyramidal cell." [NIF_Subcellular:nlx_subcell_1005001]
xref: NIF_Subcellular:nlx_subcell_1005001
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0097443
name: sorting endosome
namespace: cellular_component
def: "A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles." [NIF_Subcellular:sao1028571114]
synonym: "MVB-tubule complex" RELATED []
xref: NIF_Subcellular:sao1028571114
is_a: GO:0005768 ! endosome

[Term]
id: GO:0097444
name: spine apparatus
namespace: cellular_component
def: "A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum." [NIF_Subcellular:sao725931194, PMID:20400711, PMID:8987748]
subset: goslim_synapse
synonym: "dense material" NARROW [NIF_Subcellular:sao1004601938]
xref: NIF_Subcellular:sao725931194
is_a: GO:0043227 ! membrane-bounded organelle
relationship: part_of GO:0012505 ! endomembrane system
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0097445
name: presynaptic active zone dense projection
namespace: cellular_component
def: "Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered." [NIF_Subcellular:sao494258938, PMID:15381754]
synonym: "active zone dense projection" EXACT []
synonym: "pre-synaptic active zone dense projection" EXACT []
xref: NIF_Subcellular:sao494258938
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0097446
name: protein localization to eisosome filament
namespace: biological_process
def: "A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:mah, GOC:vw, PMID:22869600, PMID:23722945]
synonym: "protein localization to linear eisosome" EXACT []
is_a: GO:0044380 ! protein localization to cytoskeleton
is_a: GO:0072697 ! protein localization to cell cortex

[Term]
id: GO:0097447
name: dendritic tree
namespace: cellular_component
def: "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]
xref: NIF_Subcellular:sao172297168
is_a: GO:0043005 ! neuron projection
relationship: part_of GO:0036477 ! somatodendritic compartment

[Term]
id: GO:0097448
name: spine mat
namespace: cellular_component
def: "A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma." [NIF_Subcellular:sao2128156969, PMID:10818137]
xref: NIF_Subcellular:sao2128156969
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0097449
name: astrocyte projection
namespace: cellular_component
def: "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons." [NIF_Subcellular:sao1630537580]
synonym: "astrocyte process" EXACT []
synonym: "peripheral astrocyte process" RELATED [NIF_Subcellular:sao1573004591, PMID:12445894]
synonym: "vellous process" RELATED [NIF_Subcellular:sao1189060993]
xref: NIF_Subcellular:sao1630537580
is_a: GO:0097386 ! glial cell projection

[Term]
id: GO:0097450
name: astrocyte end-foot
namespace: cellular_component
def: "Terminal process of astrocyte abutting non-neuronal surfaces in the brain." [NIF_Subcellular:sao388182739]
synonym: "astrocyte endfoot" EXACT []
xref: NIF_Subcellular:sao388182739
is_a: GO:0097449 ! astrocyte projection

[Term]
id: GO:0097451
name: glial limiting end-foot
namespace: cellular_component
def: "Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans." [NIF_Subcellular:sao181458425]
synonym: "glial limiting endfoot" EXACT []
xref: NIF_Subcellular:sao181458425
is_a: GO:0097450 ! astrocyte end-foot

[Term]
id: GO:0097452
name: GAIT complex
namespace: cellular_component
def: "A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP." [GOC:br, PMID:15479637, PMID:23071094]
synonym: "gamma interferon-activated inhibitor of translation complex" EXACT []
synonym: "IFN-gamma-activated inhibitor of translation complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0097453
name: mesaxon
namespace: cellular_component
def: "Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide." [ISBN:0195065719, NIF_Subcellular:sao2127666702]
synonym: "mesaxon of Schwann cell" NARROW []
xref: NIF_Subcellular:sao2127666702
is_a: GO:1990015 ! ensheathing process

[Term]
id: GO:0097454
name: Schwann cell microvillus
namespace: cellular_component
def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042]
xref: NIF_Subcellular:sao1890444066
is_a: GO:0005902 ! microvillus
is_a: GO:0097386 ! glial cell projection

[Term]
id: GO:0097455
name: spiny bracelet of Nageotte
namespace: cellular_component
def: "Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin." [NIF_Subcellular:sao937871668, PMID:15988042]
xref: NIF_Subcellular:sao937871668
is_a: GO:0097386 ! glial cell projection

[Term]
id: GO:0097456
name: terminal loop
namespace: cellular_component
def: "Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath." [NIF_Subcellular:sao924713546]
synonym: "terminal loop of Schwann cell" EXACT []
xref: NIF_Subcellular:sao924713546
is_a: GO:0097386 ! glial cell projection

[Term]
id: GO:0097457
name: hippocampal mossy fiber
namespace: cellular_component
def: "An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709, PMID:20554881, PMID:24336151]
xref: NIF_Subcellular:nlx_subcell_100312
is_a: GO:0030424 ! axon

[Term]
id: GO:0097458
name: obsolete neuron part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [GOC:pr, Wikipedia:Neuron]
is_obsolete: true

[Term]
id: GO:0097462
name: Lewy neurite
namespace: cellular_component
def: "Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease." [NIF_Subcellular:sao601362597]
xref: NIF_Subcellular:sao601362597
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0097463
name: gemmule
namespace: cellular_component
def: "Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex." [NIF_Subcellular:nlx_subcell_1005003]
xref: NIF_Subcellular:nlx_subcell_1005003
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0097464
name: thorny excrescence
namespace: cellular_component
def: "Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads." [NIF_Subcellular:nlx_467, PMID:730852]
xref: NIF_Subcellular:nlx_467
is_a: GO:0043197 ! dendritic spine

[Term]
id: GO:0097465
name: somatic spine
namespace: cellular_component
def: "Spine emanating from the cell soma of a neuron." [NIF_Subcellular:sao2048514053]
xref: NIF_Subcellular:sao2048514053
is_a: GO:0044309 ! neuron spine

[Term]
id: GO:0097466
name: ubiquitin-dependent glycoprotein ERAD pathway
namespace: biological_process
def: "An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177]
synonym: "ER-associated glycoprotein degradation" EXACT [GOC:bf]
synonym: "glycoprotein ERAD" EXACT [GOC:bf]
synonym: "gpERAD" EXACT [PMID:25092655]
synonym: "misfolded or incompletely synthesized glycoprotein catabolic process" BROAD []
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0036503 ! ERAD pathway
is_a: GO:1904587 ! response to glycoprotein

[Term]
id: GO:0097467
name: type III terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones." [GOC:mc, PMID:10218156]
synonym: "type III terminal button" EXACT []
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:0097468
name: programmed cell death in response to reactive oxygen species
namespace: biological_process
def: "Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mtg_apoptosis]
synonym: "PCD in response to oxidative stress" BROAD []
synonym: "PCD in response to reactive oxygen species" EXACT []
synonym: "programmed cell death in response to oxidative stress" BROAD []
synonym: "reactive oxygen species-mediated PCD" EXACT []
synonym: "reactive oxygen species-mediated programmed cell death" EXACT []
is_a: GO:0012501 ! programmed cell death
relationship: part_of GO:0034614 ! cellular response to reactive oxygen species

[Term]
id: GO:0097469
name: obsolete cyclin-dependent protein tyrosine kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. This reaction requires the binding of a regulatory cyclin subunit." [GOC:al, GOC:vw, PMID:1372994]
comment: This term was made obsolete because it was added in error; the specific activity it refers to has never been observed.
synonym: "cyclin-dependent protein tyrosine kinase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0097470
name: ribbon synapse
namespace: cellular_component
def: "Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm." [NIF_Subcellular:sao1884931180, PMID:15626493]
synonym: "synapsis fasciolaris" EXACT [Wikipedia:Ribbon_synapse&oldid=757407851]
xref: NIF_Subcellular:sao1884931180
is_a: GO:0045202 ! synapse

[Term]
id: GO:0097471
name: mossy fiber rosette
namespace: cellular_component
def: "A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes." [NIF_Subcellular:nlx_subcell_091021, Wikipedia:Mossy_fiber_(cerebellum)]
subset: goslim_synapse
synonym: "cerebellar mossy fiber to granule cell synapse" EXACT syngo_official_label []
xref: NIF_Subcellular:nlx_subcell_091021
is_a: GO:0032279 ! asymmetric synapse

[Term]
id: GO:0097472
name: cyclin-dependent protein kinase activity
namespace: molecular_function
def: "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr]
comment: This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0097473
name: retinal rod cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487]
synonym: "rod photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process

[Term]
id: GO:0097474
name: retinal cone cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc]
synonym: "cone photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process

[Term]
id: GO:0097475
name: motor neuron migration
namespace: biological_process
def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475]
is_a: GO:0001764 ! neuron migration

[Term]
id: GO:0097476
name: spinal cord motor neuron migration
namespace: biological_process
def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475]
is_a: GO:0097475 ! motor neuron migration

[Term]
id: GO:0097477
name: lateral motor column neuron migration
namespace: biological_process
def: "The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [CL:0011002, GOC:yaf, PMID:20711475]
is_a: GO:0097476 ! spinal cord motor neuron migration

[Term]
id: GO:0097478
name: leaflet of membrane bilayer
namespace: cellular_component
def: "Any of the two layers of lipid molecules that constitute a membrane." [GOC:cjm]
synonym: "membrane leaflet" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0097479
name: synaptic vesicle localization
namespace: biological_process
def: "Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:pr]
synonym: "establishment and maintenance of synaptic vesicle localization" EXACT []
synonym: "establishment and maintenance of synaptic vesicle position" EXACT []
synonym: "synaptic vesicle localisation" EXACT []
is_a: GO:0051648 ! vesicle localization

[Term]
id: GO:0097480
name: establishment of synaptic vesicle localization
namespace: biological_process
def: "The directed movement of a synaptic vesicle or vesicles to a specific location." [GOC:pr]
synonym: "establishment of synaptic vesicle localisation" EXACT []
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0097479 ! synaptic vesicle localization

[Term]
id: GO:0097482
name: muscle cell postsynaptic specialization
namespace: cellular_component
def: "A postsynaptic specialization that is part of a neuromuscular junction." [GOC:pr]
synonym: "muscle cell postsynaptic density" EXACT []
synonym: "muscle fiber postsynaptic density" EXACT []
is_a: GO:0099572 ! postsynaptic specialization
relationship: part_of GO:0098975 ! postsynapse of neuromuscular junction

[Term]
id: GO:0097484
name: dendrite extension
namespace: biological_process
def: "Long distance growth of a single dendrite involved in cellular development." [GOC:BHF, GOC:rl]
is_a: GO:1990138 ! neuron projection extension

[Term]
id: GO:0097485
name: neuron projection guidance
namespace: biological_process
def: "The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "neurite guidance" NARROW []
synonym: "neuron process guidance" EXACT []
synonym: "neuron protrusion guidance" EXACT []
synonym: "neuronal cell projection guidance" EXACT []
is_a: GO:0031175 ! neuron projection development
relationship: part_of GO:0048812 ! neuron projection morphogenesis

[Term]
id: GO:0097486
name: multivesicular body lumen
namespace: cellular_component
def: "The volume enclosed by the outermost membrane of a multivesicular body." [GOC:pde, PMID:21183070]
is_a: GO:0031906 ! late endosome lumen
relationship: part_of GO:0005771 ! multivesicular body

[Term]
id: GO:0097487
name: multivesicular body, internal vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle wholly contained within a multivesicular body." [GOC:pde, PMID:21183070]
is_a: GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0005771 ! multivesicular body

[Term]
id: GO:0097488
name: multivesicular body, internal vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a multivesicular body internal vesicle." [GOC:pde, PMID:21183070]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0097487 ! multivesicular body, internal vesicle

[Term]
id: GO:0097489
name: multivesicular body, internal vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the multivesicular body internal vesicle." [GOC:pde, PMID:21183070]
is_a: GO:0031983 ! vesicle lumen
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0097487 ! multivesicular body, internal vesicle

[Term]
id: GO:0097490
name: sympathetic neuron projection extension
namespace: biological_process
def: "Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "sympathetic neurite extension" NARROW []
synonym: "sympathetic neuron process extension" EXACT []
synonym: "sympathetic neuron protrusion extension" EXACT []
synonym: "sympathetic neuronal cell projection extension" EXACT []
is_a: GO:1990138 ! neuron projection extension

[Term]
id: GO:0097491
name: sympathetic neuron projection guidance
namespace: biological_process
def: "The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "sympathetic neurite guidance" NARROW []
synonym: "sympathetic neuron process guidance" EXACT []
synonym: "sympathetic neuron protrusion guidance" EXACT []
synonym: "sympathetic neuronal cell projection guidance" EXACT []
is_a: GO:0097485 ! neuron projection guidance

[Term]
id: GO:0097492
name: sympathetic neuron axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "sympathetic neuron axon chemotaxis" RELATED []
synonym: "sympathetic neuron axon growth cone guidance" NARROW []
synonym: "sympathetic neuron axon pathfinding" EXACT []
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0097493
name: structural molecule activity conferring elasticity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling." [GOC:BHF, GOC:rl, PMID:23283722]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0097494
name: regulation of vesicle size
namespace: biological_process
def: "Any process that modulates the size of a vesicle." [GOC:pm, PMID:20007772]
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0097495
name: H-NS-Hha complex
namespace: cellular_component
def: "A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:21600204]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0097496
name: blood vessel lumen ensheathment
namespace: biological_process
def: "A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel." [GOC:dgh, PMID:23698350]
is_a: GO:0072554 ! blood vessel lumenization

[Term]
id: GO:0097497
name: blood vessel endothelial cell delamination
namespace: biological_process
def: "The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet." [GOC:dgh, PMID:23698350]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0097498
name: endothelial tube lumen extension
namespace: biological_process
def: "Any endothelial tube morphogenesis process by which the tube is increased in length." [GOC:dgh, PMID:23698350]
is_a: GO:0061154 ! endothelial tube morphogenesis

[Term]
id: GO:0097499
name: protein localization to non-motile cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241]
synonym: "protein localization to nonmotile primary cilium" RELATED []
is_a: GO:0061512 ! protein localization to cilium

[Term]
id: GO:0097500
name: receptor localization to non-motile cilium
namespace: biological_process
def: "A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241]
synonym: "receptor localization to nonmotile primary cilium" RELATED []
is_a: GO:0097499 ! protein localization to non-motile cilium
is_a: GO:1903441 ! protein localization to ciliary membrane

[Term]
id: GO:0097501
name: stress response to metal ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus." [GOC:kmv]
synonym: "response to excess metal ion" RELATED []
synonym: "response to metal ion stress" EXACT []
synonym: "response to metal ion toxicity" RELATED []
synonym: "response to metal toxicity" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0097502
name: mannosylation
namespace: biological_process
def: "The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm]
subset: gocheck_obsoletion_candidate
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0097503
name: sialylation
namespace: biological_process
def: "The covalent attachment of sialic acid to a substrate molecule." [GOC:cjm]
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0097504
name: Gemini of coiled bodies
namespace: cellular_component
def: "Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems]
synonym: "Gems" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0097505
name: Rad6-Rad18 complex
namespace: cellular_component
def: "A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity." [GOC:jd, PMID:9287349]
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:0097506
name: deaminated base DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated bases." [GOC:al, PMID:18789404]
synonym: "deaminated base DNA glycosylase activity" EXACT []
synonym: "DNA glycosylase activity acting on deaminated bases" EXACT []
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0097507
name: hypoxanthine DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)." [GOC:al, PMID:18789404]
synonym: "hypoxanthine-DNA glycosylase activity" RELATED []
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity

[Term]
id: GO:0097508
name: xanthine DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated guanine (xanthine)." [GOC:al, PMID:18789404]
synonym: "xanthine-DNA glycosylase activity" RELATED []
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity

[Term]
id: GO:0097509
name: oxanine DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination." [GOC:al, PMID:18789404]
synonym: "oxanine-DNA glycosylase activity" RELATED []
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity

[Term]
id: GO:0097510
name: base-excision repair, AP site formation via deaminated base removal
namespace: biological_process
def: "A base-excision repair, AP site formation process occurring via excision of a deaminated base." [GOC:al, PMID:18789404]
is_a: GO:0006285 ! base-excision repair, AP site formation

[Term]
id: GO:0097511
name: dendritic cell dendrite
namespace: cellular_component
def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351]
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0097512
name: cardiac myofibril
namespace: cellular_component
def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol]
is_a: GO:0030016 ! myofibril

[Term]
id: GO:0097513
name: myosin II filament
namespace: cellular_component
def: "A bipolar filament composed of myosin II molecules." [GOC:cjm, GOC:mah]
is_a: GO:0032982 ! myosin filament

[Term]
id: GO:0097514
name: sexual spore wall
namespace: cellular_component
def: "A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:cjm, GOC:mah]
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0097515
name: asexual spore wall
namespace: cellular_component
def: "A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species." [GOC:cjm, GOC:mah]
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0097516
name: microvillar actin bundle
namespace: cellular_component
def: "A parallel bundle of actin filaments at the core of a microvillus." [GOC:cjm, GOC:mah]
is_a: GO:0098859 ! actin filament bundle of actin-based cell projection
relationship: part_of GO:0005902 ! microvillus

[Term]
id: GO:0097517
name: contractile actin filament bundle
namespace: cellular_component
def: "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194]
is_a: GO:0032432 ! actin filament bundle

[Term]
id: GO:0097518
name: parallel actin filament bundle
namespace: cellular_component
def: "An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:cjm, GOC:mah, ISBN:0815316194]
is_a: GO:0032432 ! actin filament bundle

[Term]
id: GO:0097519
name: DNA recombinase complex
namespace: cellular_component
def: "A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA." [GOC:cjm, PMID:10357855]
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0097520
name: nucleotide-excision repair, preincision complex
namespace: cellular_component
def: "A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage." [GOC:cjm, GOC:elh, PMID:10197977]
synonym: "UvrA(2)-UvrB(2) complex" NARROW [PMID:12145219]
synonym: "UvrA(2)B(2) complex" NARROW [GOC:bhm, PMID:12145219]
synonym: "UvrB dimer" NARROW [GOC:bhm, PMID:12145219]
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0097522
name: protein-DNA ISRE complex
namespace: cellular_component
def: "A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, GOC:cjm, PMID:11747630]
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0097523
name: transcription ternary complex
namespace: cellular_component
def: "A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript." [GOC:cjm, GOC:txnOH]
synonym: "transcription protein-DNA-RNA complex" EXACT []
is_a: GO:0001114 ! protein-DNA-RNA complex

[Term]
id: GO:0097524
name: sperm plasma membrane
namespace: cellular_component
def: "A plasma membrane that is part of a sperm cell." [GOC:cjm]
is_a: GO:0005886 ! plasma membrane

[Term]
id: GO:0097525
name: spliceosomal snRNP complex
namespace: cellular_component
def: "A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0097526
name: spliceosomal tri-snRNP complex
namespace: cellular_component
def: "A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0097527
name: necroptotic signaling pathway
namespace: biological_process
def: "The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered." [GOC:mtg_apoptosis, PMID:20823910]
comment: Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality.
synonym: "necroptosis signaling" RELATED []
synonym: "necroptosis signaling pathway" EXACT []
synonym: "necroptotic signal transduction" EXACT [GOC:signaling]
synonym: "necroptotic signalling pathway" RELATED []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0070266 ! necroptotic process

[Term]
id: GO:0097528
name: execution phase of necroptosis
namespace: biological_process
def: "A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died." [GOC:mtg_apoptosis, PMID:20823910]
synonym: "execution phase of necroptotic process" EXACT []
synonym: "necroptosis" BROAD []
synonym: "necroptotic execution phase" EXACT []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0070266 ! necroptotic process

[Term]
id: GO:0097529
name: myeloid leukocyte migration
namespace: biological_process
def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461]
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0097530
name: granulocyte migration
namespace: biological_process
def: "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336]
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0097531
name: mast cell migration
namespace: biological_process
def: "The movement of a mast cell within or between different tissues and organs of the body." [GOC:cvs, PMID:24152847]
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0097532
name: stress response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049, PMID:19170886, Wikipedia:Acid]
synonym: "response to acid stress" BROAD []
synonym: "stress response to acid" BROAD []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0097533
name: cellular stress response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049, PMID:19170886, Wikipedia:Acid]
synonym: "cellular response to acid stress" BROAD []
synonym: "cellular stress response to acid" BROAD []
is_a: GO:0097532 ! stress response to acid chemical
relationship: part_of GO:0033554 ! cellular response to stress
relationship: part_of GO:0071229 ! cellular response to acid chemical

[Term]
id: GO:0097534
name: lymphoid lineage cell migration
namespace: biological_process
def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843]
synonym: "lymphoid lineage restricted progenitor cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0097535
name: lymphoid lineage cell migration into thymus
namespace: biological_process
def: "The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process." [GOC:cvs, PMID:22342843]
synonym: "lymphoid lineage restricted progenitor cell migration into thymus" EXACT []
is_a: GO:0097534 ! lymphoid lineage cell migration

[Term]
id: GO:0097536
name: thymus epithelium morphogenesis
namespace: biological_process
def: "The process in which the thymus epithelium is generated and organized." [GOC:pr, PMID:22342843]
synonym: "thymic epithelium morphogenesis" EXACT []
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0048538 ! thymus development

[Term]
id: GO:0097537
name: Y-shaped link
namespace: cellular_component
def: "A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium." [GOC:cilia, PMID:22653444, PMID:4554367]
synonym: "membrane-microtubule complex" RELATED []
synonym: "Y-link" RELATED []
synonym: "Y-link structure" RELATED []
synonym: "Y-shaped assemblage" RELATED []
synonym: "Y-shaped fiber" RELATED []
synonym: "Y-shaped fibre" RELATED []
synonym: "Y-shaped linker" RELATED []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0035869 ! ciliary transition zone

[Term]
id: GO:0097538
name: ciliary necklace
namespace: cellular_component
def: "A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links." [GOC:cilia, PMID:22653444, PMID:4554367]
synonym: "cilial necklace" EXACT []
synonym: "cilium necklace" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0035869 ! ciliary transition zone
relationship: part_of GO:0060170 ! ciliary membrane

[Term]
id: GO:0097539
name: ciliary transition fiber
namespace: cellular_component
def: "A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium)." [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]
comment: In mammals, ciliary transition fibers comprise at least five components (Ccdc41/Cep83, Cep89/Cep123, Sclt1, Fbf1, and Cep164) (PMID:24469809).
synonym: "centriolar distal appendage" RELATED [PMID:24469809]
synonym: "cilial transition fiber" EXACT []
synonym: "cilial transition fibre" EXACT []
synonym: "ciliary transition fibre" EXACT []
synonym: "cilium transition fiber" EXACT []
synonym: "cilium transition fibre" EXACT []
synonym: "distal appendage of basal body" RELATED [GOC:krc]
synonym: "distal appendage of centriole" RELATED [GOC:krc]
synonym: "distal appendage of mother centriole" RELATED [GOC:krc]
synonym: "transition fiber" BROAD []
synonym: "transition fibre" BROAD []
is_a: GO:0140535 ! intracellular protein-containing complex
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0097540
name: axonemal central pair
namespace: cellular_component
def: "Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia." [GOC:cilia, GOC:krc, PMID:24283352]
synonym: "axonemal microtubule central pair" EXACT []
synonym: "axoneme central pair" EXACT []
synonym: "axoneme microtubule central pair" EXACT []
synonym: "central pair" BROAD []
synonym: "central-pair microtubules" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:1990716 ! axonemal central apparatus

[Term]
id: GO:0097541
name: axonemal basal plate
namespace: cellular_component
def: "Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure." [GOC:cilia, PMID:23352055, PMID:4554367]
synonym: "axoneme basal plate" EXACT []
synonym: "basal plate" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0097542
name: ciliary tip
namespace: cellular_component
def: "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial tip" EXACT []
synonym: "cilium tip" EXACT []
synonym: "flagellar tip" EXACT []
synonym: "flagellum tip" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0097543
name: ciliary inversin compartment
namespace: cellular_component
def: "Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium." [GOC:cilia, PMID:19050042]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial inversin compartment" EXACT []
synonym: "cilium inversin compartment" EXACT []
synonym: "flagellar inversin compartment" EXACT []
synonym: "flagellum inversin compartment" EXACT []
synonym: "Inv compartment of the cilium" EXACT []
synonym: "inversin compartment" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0097544
name: ciliary shaft
namespace: cellular_component
def: "The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space." [GOC:cilia, GOC:krc, PMID:19866682]
comment: Note that 'ciliary shaft' is sparingly used in the literature to denote the projecting part of the cilium; many authors would refer to the axoneme instead. However, the definition of GO:0005930 'axoneme' is rather stringent, and the localization of many ciliary proteins would not fit that definition. Also, note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial shaft" EXACT []
synonym: "cilium shaft" EXACT []
synonym: "flagellar shaft" EXACT []
synonym: "flagellum shaft" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0097545
name: axonemal doublet microtubule
namespace: cellular_component
def: "A cellular anatomical entity that is part of an axoneme consisting of a doublet microtubule." [GOC:cilia, GOC:krc, GOC:pr, https://github.com/geneontology/go-ontology/issues/26128, PMID:5044758, PMID:5664206, Wikipedia:Axoneme]
synonym: "axonemal outer doublet" EXACT []
synonym: "axoneme outer doublet" EXACT []
synonym: "DMT" RELATED []
synonym: "outer doublet" BROAD []
synonym: "outer-doublet microtubules" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0097546
name: ciliary base
namespace: cellular_component
def: "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]
comment: Due to resolution issues, researchers are often unable to assign protein localization to more specific ciliary compartments such as the basal body, transition fibers or transition zone, and instead refer to 'ciliary base'. The terms GO:0036064 'ciliary basal body', GO:0097539 'ciliary transition fiber' and GO:0035869 'ciliary transition zone' represent strictly defined compartments at the ciliary base and should be used for annotation whenever possible. Also, note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial base" EXACT []
synonym: "cilium base" EXACT []
synonym: "flagellar base" EXACT []
synonym: "flagellum base" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0097547
name: synaptic vesicle protein transport vesicle
namespace: cellular_component
def: "A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270]
comment: This term should not be confused with GO:0008021 'synaptic vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.
synonym: "STV" EXACT []
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0097548
name: seed abscission
namespace: biological_process
def: "The controlled shedding of a seed." [GOC:lmo]
is_a: GO:0009838 ! abscission

[Term]
id: GO:0097549
name: obsolete chromatin organization involved in negative regulation of transcription
namespace: biological_process
alt_id: GO:1903758
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription by chromatin organization." [GOC:di, PMID:23123093]
comment: This term was obsoleted because these it was redundant with other terms: heterochromatin assembly and negative regulation of gene expression, epigenetic.
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription by chromatin organization" EXACT []
synonym: "negative regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter by histone modification" NARROW []
synonym: "negative regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:0097550
name: transcription preinitiation complex
namespace: cellular_component
def: "A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016]
synonym: "DNA-templated transcriptional preinitiation complex" EXACT []
synonym: "PIC" NARROW []
synonym: "preinitiation complex" NARROW []
synonym: "transcriptional pre-initiation complex" EXACT []
synonym: "transcriptional preinitiation complex" EXACT []
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0097551
name: mitochondrial double-strand break repair
namespace: biological_process
def: "The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:di, PMID:22214610]
comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable.
synonym: "mtDSB repair" EXACT []
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0097552
name: mitochondrial double-strand break repair via homologous recombination
namespace: biological_process
def: "The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:di, PMID:22214610]
comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable.
synonym: "mtDSB repair via homologous recombination" EXACT []
is_a: GO:0000725 ! recombinational repair
is_a: GO:0097551 ! mitochondrial double-strand break repair

[Term]
id: GO:0097553
name: calcium ion transmembrane import into cytosol
namespace: biological_process
alt_id: GO:0060401
def: "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "calcium transmembrane import into cytosol" BROAD []
synonym: "cytosolic calcium ion transport" BROAD []
is_a: GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0097554
name: left anterior flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left anterior cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097555
name: right anterior flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right anterior cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097556
name: left posteriolateral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left posteriolateral cilium" EXACT []
synonym: "left posterolateral cilium" EXACT []
synonym: "left posterolateral flagellum" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097557
name: right posteriolateral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right posteriolateral cilium" EXACT []
synonym: "right posterolateral cilium" EXACT []
synonym: "right posterolateral flagellum" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097558
name: left ventral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left ventral cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097559
name: right ventral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right ventral cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097560
name: left caudal flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left caudal cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097561
name: right caudal flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right caudal cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097562
name: left lateral basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0097563
name: left middle basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0097564
name: right lateral basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0097565
name: right middle basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0097566
name: left tetrad
namespace: cellular_component
def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0097567
name: right tetrad
namespace: cellular_component
def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0097568
name: median body
namespace: cellular_component
def: "A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc." [GOC:giardia, PMID:5961344]
comment: Note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "parabasal body" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0097569
name: lateral shield
namespace: cellular_component
def: "Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella." [GOC:giardia, ISBN:9780124260207]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044297 ! cell body

[Term]
id: GO:0097570
name: cyst wall
namespace: cellular_component
def: "The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins." [GOC:giardia, PMID:15134259, PMID:2026212, Wikipedia:Microbial_cyst]
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0097571
name: left nucleus
namespace: cellular_component
def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0097572
name: right nucleus
namespace: cellular_component
def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0097573
name: obsolete glutathione oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione." [GOC:jd, PMID:18992757]
comment: This term was obsoleted because it is redundant with other terms.
is_obsolete: true
consider: GO:0004362
consider: GO:0015038
consider: GO:0045174

[Term]
id: GO:0097574
name: lateral part of cell
namespace: cellular_component
def: "The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells." [GOC:pr]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0097575
name: lateral cell cortex
namespace: cellular_component
def: "The region directly beneath the plasma membrane of the lateral portion of the cell." [GOC:mah, PMID:24146635]
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0097574 ! lateral part of cell

[Term]
id: GO:0097576
name: vacuole fusion
namespace: biological_process
def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048284 ! organelle fusion

[Term]
id: GO:0097577
name: obsolete sequestering of iron ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining iron ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "iron ion retention" EXACT []
synonym: "iron ion sequestering" EXACT []
synonym: "iron ion sequestration" EXACT []
synonym: "iron ion storage" EXACT []
synonym: "retention of iron ion" EXACT []
synonym: "sequestration of iron ion" EXACT []
synonym: "storage of iron ion" EXACT []
is_obsolete: true
consider: GO:0140315

[Term]
id: GO:0097578
name: obsolete sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining copper ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process
synonym: "copper ion retention" EXACT []
synonym: "copper ion sequestering" EXACT []
synonym: "copper ion sequestration" EXACT []
synonym: "copper ion storage" EXACT []
synonym: "retention of copper ion" EXACT []
synonym: "sequestration of copper ion" EXACT []
synonym: "storage of copper ion" EXACT []
is_obsolete: true
consider: GO:0140487

[Term]
id: GO:0097579
name: obsolete extracellular sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "extracellular copper ion retention" EXACT []
synonym: "extracellular copper ion sequestering" EXACT []
synonym: "extracellular copper ion sequestration" EXACT []
synonym: "extracellular copper ion storage" EXACT []
synonym: "extracellular retention of copper ion" EXACT []
synonym: "extracellular sequestration of copper ion" EXACT []
synonym: "extracellular storage of copper ion" EXACT []
is_obsolete: true
consider: GO:0140487

[Term]
id: GO:0097580
name: obsolete intracellular sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
synonym: "intracellular copper ion retention" EXACT []
synonym: "intracellular copper ion sequestering" EXACT []
synonym: "intracellular copper ion sequestration" EXACT []
synonym: "intracellular copper ion storage" EXACT []
synonym: "intracellular retention of copper ion" EXACT []
synonym: "intracellular sequestration of copper ion" EXACT []
synonym: "intracellular storage of copper ion" EXACT []
is_obsolete: true
consider: GO:0140487

[Term]
id: GO:0097581
name: lamellipodium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [GOC:als, PMID:16054028]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0097582
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p." [GOC:jd, PMID:12551906]
synonym: "Pmt1p-Pmt2p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex

[Term]
id: GO:0097583
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p." [GOC:jd, PMID:12551906]
synonym: "Pmt1p-Pmt3p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex

[Term]
id: GO:0097584
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p." [GOC:jd, PMID:12551906]
synonym: "Pmt5p-Pmt2p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex

[Term]
id: GO:0097585
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p." [GOC:jd, PMID:12551906]
synonym: "Pmt5p-Pmt3p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex

[Term]
id: GO:0097586
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p." [GOC:bhm, GOC:jd, PMID:12551906]
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer" EXACT []
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex" EXACT []
synonym: "Pmt4p-Pmt4p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex

[Term]
id: GO:0097587
name: MutLgamma complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3." [GOC:jd, PMID:10570173]
is_a: GO:0032300 ! mismatch repair complex

[Term]
id: GO:0097588
name: archaeal or bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to movement of bacterial- or archaeal-type flagella." [GOC:cilia, GOC:krc]
comment: Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. This term was added for mapping to the UniProt keyword "flagellar rotation". For manual annotation, please use one of the child terms of GO:0097588 that refer specifically to either archaeal- or bacterial-type flagella.
is_a: GO:0001539 ! cilium or flagellum-dependent cell motility

[Term]
id: GO:0097589
name: archaeal-type flagellum
namespace: cellular_component
def: "A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function." [GOC:cilia, GOC:krc, PMID:21265748, PMID:23146836, PMID:23204365, PMID:24330313, Wikipedia:Flagellum#Archaeal]
synonym: "archaeal flagellum" RELATED []
synonym: "archaella" RELATED []
synonym: "archaellum" EXACT []
is_a: GO:0042995 ! cell projection
is_a: GO:0043228 ! membraneless organelle

[Term]
id: GO:0097590
name: archaeal-type flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel." [GOC:cilia, GOC:krc, Wikipedia:Flagellum#Archaeal]
synonym: "archaeal-type flagellar cell motility" RELATED []
is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility

[Term]
id: GO:0097591
name: ventral disc lateral crest
namespace: cellular_component
def: "Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "lateral crest" BROAD []
synonym: "ventral disk lateral crest" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097597 ! ventral disc

[Term]
id: GO:0097592
name: ventral disc overlap zone
namespace: cellular_component
def: "A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself)." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "overlap zone" BROAD []
synonym: "ventral disk overlap zone" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097597 ! ventral disc

[Term]
id: GO:0097593
name: ventral disc microtubule array
namespace: cellular_component
def: "A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "spiral microtubule array" BROAD []
synonym: "ventral disc spiral microtubule array" EXACT []
synonym: "ventral disk microtubule array" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097597 ! ventral disc

[Term]
id: GO:0097594
name: ventral disc dorsal microribbon
namespace: cellular_component
def: "Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons." [GOC:giardia, PMID:11432808]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "dorsal microribbon" BROAD []
synonym: "dorsal ribbon" BROAD []
synonym: "microribbon" BROAD []
synonym: "ventral disk dorsal microribbon" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097597 ! ventral disc

[Term]
id: GO:0097595
name: ventral disc crossbridge
namespace: cellular_component
def: "Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "crossbridge" BROAD []
synonym: "ventral disk crossbridge" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097597 ! ventral disc

[Term]
id: GO:0097596
name: ventral disc supernumerary microtubule array
namespace: cellular_component
def: "A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage)." [GOC:giardia, ISBN:9780124260207]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "supernumerary microtubule array" BROAD []
synonym: "ventral disk supernumerary microtubule array" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097597 ! ventral disc

[Term]
id: GO:0097597
name: ventral disc
namespace: cellular_component
def: "Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence." [GOC:giardia, ISBN:9780124260207, PMID:11432808, PMID:4777416, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "adhesive disc" RELATED []
synonym: "ventral adhesive disc" EXACT []
synonym: "ventral disk" RELATED []
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0097598
name: sperm cytoplasmic droplet
namespace: cellular_component
def: "A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce what are called residual bodies. Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted." [GOC:krc, GOC:vesicles, PMID:12672117, PMID:21076437, PMID:23159014]
synonym: "sperm residual cytoplasm" EXACT []
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0097599
name: xylanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues." [GOC:jh2, ISBN:81-7736-269-0]
synonym: "xylosidase activity" RELATED []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0097600
name: exoxylanase activity
namespace: molecular_function
def: "A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains." [GOC:jh2, ISBN:81-7736-269-0, PMID:16535010]
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0097601
name: retina blood vessel maintenance
namespace: biological_process
def: "A retina homeostatic process preventing the degeneration of a retina blood vessel." [GOC:jh2, PMID:23093773]
synonym: "maintenance of choriocapillaris" NARROW []
synonym: "maintenance of retina blood vessel" EXACT []
synonym: "maintenance of retinal blood vessel" EXACT []
is_a: GO:0001895 ! retina homeostasis

[Term]
id: GO:0097602
name: cullin family protein binding
namespace: molecular_function
def: "Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]
synonym: "cullin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0097603
name: temperature-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824]
synonym: "heat-activated ion channel activity" NARROW []
synonym: "temperature gated ion channel activity" EXACT []
synonym: "temperature-activated ion channel activity" EXACT []
synonym: "temperature-dependent ion channel activity" EXACT []
is_a: GO:0005216 ! monoatomic ion channel activity
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0097604
name: temperature-gated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824]
synonym: "heat-activated cation channel activity" NARROW []
synonym: "temperature gated cation channel activity" EXACT []
synonym: "temperature-activated cation channel activity" EXACT []
synonym: "temperature-dependent cation channel activity" EXACT []
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0097603 ! temperature-gated ion channel activity

[Term]
id: GO:0097605
name: obsolete regulation of nuclear envelope permeability
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr]
comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it.
synonym: "regulation of nuclear membrane permeability" RELATED []
is_obsolete: true

[Term]
id: GO:0097606
name: obsolete positive regulation of nuclear envelope permeability
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr]
comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it.
synonym: "positive regulation of nuclear membrane permeability" RELATED []
is_obsolete: true

[Term]
id: GO:0097607
name: obsolete negative regulation of nuclear envelope permeability
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr]
comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it.
synonym: "negative regulation of nuclear membrane permeability" RELATED []
is_obsolete: true

[Term]
id: GO:0097608
name: transverse flagellum
namespace: cellular_component
def: "A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum." [GOC:at, http://tolweb.org/Dinoflagellates/2445, https://doi.org/10.1038/213421a0, Wikipedia:Dinoflagellate#Morphology]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate.
synonym: "transverse cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097609
name: longitudinal flagellum
namespace: cellular_component
def: "A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus." [GOC:at, http://tolweb.org/Dinoflagellates/2445, https://doi.org/10.1508/cytologia.88.321, Wikipedia:Dinoflagellate#Morphology]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate.
synonym: "longitudinal cilium" EXACT []
is_a: GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097610
name: cell surface furrow
namespace: cellular_component
def: "A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates." [GOC:pr]
synonym: "cell surface groove" RELATED []
synonym: "furrow" BROAD []
synonym: "groove" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0097611
name: dinoflagellate cingulum
namespace: cellular_component
def: "A cell surface furrow that wraps around a dinoflagellate cell; the transverse flagellum lies in it." [GOC:at, http://tolweb.org/Dinoflagellates/2445, PMID:7002229, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "cingulum" BROAD []
synonym: "girdle" RELATED []
synonym: "transverse groove" RELATED []
is_a: GO:0097610 ! cell surface furrow

[Term]
id: GO:0097612
name: dinoflagellate sulcus
namespace: cellular_component
def: "A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell." [GOC:at, http://tolweb.org/Dinoflagellates/2445, PMID:20561119, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side).
synonym: "longitudinal furrow" RELATED []
synonym: "longitudinal groove" RELATED []
synonym: "sulcus" BROAD []
is_a: GO:0097610 ! cell surface furrow

[Term]
id: GO:0097613
name: dinoflagellate epicone
namespace: cellular_component
def: "The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum." [GOC:at, http://tolweb.org/Dinoflagellates/2445, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "epicone" BROAD []
synonym: "episome" RELATED []
synonym: "epitheca" RELATED []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0097614
name: dinoflagellate hypocone
namespace: cellular_component
def: "The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum." [GOC:at, http://tolweb.org/Dinoflagellates/2445, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "hypocone" BROAD []
synonym: "hyposome" RELATED []
synonym: "hypotheca" RELATED []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0097615
name: modulation by host of symbiont type IV pilus-dependent motility
namespace: biological_process
def: "The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568]
synonym: "modulation by host of bacterial type IV pilus-dependent motility" EXACT []
is_a: GO:0051851 ! modulation by host of symbiont process

[Term]
id: GO:0097616
name: positive regulation by host of symbiont type IV pilus-dependent motility
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568]
synonym: "positive regulation by host of bacterial type IV pilus-dependent motility" EXACT []
is_a: GO:0097615 ! modulation by host of symbiont type IV pilus-dependent motility

[Term]
id: GO:0097618
name: dinoflagellate sulcal notch
namespace: cellular_component
def: "A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed." [GOC:at, http://tolweb.org/Dinoflagellates/2445, PMID:7002229, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). The term 'sulcal notch' appears mostly in older literature; more recently, indication of a bilobed hypocone is used to express the same.
synonym: "dinoflagellate sulcus notch" EXACT []
synonym: "sulcal notch" RELATED []
is_a: GO:0097612 ! dinoflagellate sulcus

[Term]
id: GO:0097619
name: PTEX complex
namespace: cellular_component
def: "A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components." [GOC:pr, PMID:19536257, PMID:25043010, PMID:25043043]
synonym: "Plasmodium translocon of exported proteins" RELATED []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane

[Term]
id: GO:0097620
name: (R)-mandelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor." [GOC:pr, PMID:1731758, RHEA:43112]
comment: In the yeast Rhodotorula graminis, (R)-mandelate dehydrogenase is the first enzyme of the mandelate pathway, and catalyzes the NAD-dependent oxidation of (R)-mandelate to phenylglyoxylate.
synonym: "D-mandelate dehydrogenase activity" EXACT []
xref: RHEA:43112
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0097621
name: monoamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2." [GOC:pr, PMID:15279562, PMID:16129825]
comment: Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC:1.4.3.21, primary amine oxidase as it can oxidize secondary and tertiary amines but not methylamine.
synonym: "amine:oxygen oxidoreductase (deaminating) activity" EXACT []
xref: EC:1.4.3.4
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0097622
name: cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm." [GOC:mcc, PMID:24923804]
is_a: GO:0002182 ! cytoplasmic translational elongation

[Term]
id: GO:0097623
name: potassium ion export across plasma membrane
namespace: biological_process
alt_id: GO:0071435
alt_id: GO:0098668
def: "The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:11932440]
synonym: "potassium export" BROAD [GOC:mah]
synonym: "potassium export across plasma membrane" EXACT []
synonym: "potassium ion export" BROAD []
synonym: "potassium ion export from cell" EXACT []
is_a: GO:0071805 ! potassium ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0097624
name: UDP-galactose transmembrane import into Golgi lumen
namespace: biological_process
def: "The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane." [GOC:vw, PMID:11378902]
synonym: "UDP-galactose import into Golgi lumen" BROAD []
is_a: GO:0072334 ! UDP-galactose transmembrane transport

[Term]
id: GO:0097625
name: low-affinity basic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:pr]
synonym: "low affinity basic amino acid transmembrane transporter activity" EXACT []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity

[Term]
id: GO:0097626
name: low-affinity L-arginine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:krc, PMID:8195186]
synonym: "low affinity L-arginine transmembrane transporter activity" EXACT []
is_a: GO:0061459 ! L-arginine transmembrane transporter activity
is_a: GO:0097625 ! low-affinity basic amino acid transmembrane transporter activity

[Term]
id: GO:0097627
name: high-affinity L-ornithine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:krc, PMID:8195186]
synonym: "high affinity L-ornithine transmembrane transporter activity" EXACT []
is_a: GO:0000064 ! L-ornithine transmembrane transporter activity

[Term]
id: GO:0097628
name: distal tip cell migration
namespace: biological_process
def: "The orderly movement of a distal tip cell." [CL:0000661, GOC:mm2, PMID:24968003]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0097629
name: extrinsic component of omegasome membrane
namespace: cellular_component
def: "The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf, PMID:18725538, PMID:24591649]
synonym: "extrinsic to omegasome membrane" EXACT []
synonym: "omegasome peripheral membrane" RELATED []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:1903349 ! omegasome membrane

[Term]
id: GO:0097630
name: obsolete intrinsic component of omegasome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the omegasome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf, PMID:18725538, PMID:24591649]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to omegasome membrane" NARROW []
is_obsolete: true
replaced_by: GO:1903349

[Term]
id: GO:0097631
name: obsolete integral component of omegasome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the omegasome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf, PMID:18725538, PMID:24591649]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to omegasome membrane" NARROW []
synonym: "omegasome integral membrane protein" RELATED []
is_obsolete: true
replaced_by: GO:1903349

[Term]
id: GO:0097632
name: extrinsic component of phagophore assembly site membrane
namespace: cellular_component
def: "The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf]
synonym: "extrinsic component of pre-autophagosomal structure membrane" NARROW []
synonym: "extrinsic to phagophore assembly site membrane" EXACT []
synonym: "phagophore assembly site peripheral membrane" RELATED []
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0034045 ! phagophore assembly site membrane

[Term]
id: GO:0097633
name: obsolete intrinsic component of phagophore assembly site membrane
namespace: cellular_component
def: "OBSOLETE. The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to phagophore assembly site membrane" NARROW []
is_obsolete: true
replaced_by: GO:0034045

[Term]
id: GO:0097634
name: obsolete integral component of phagophore assembly site membrane
namespace: cellular_component
def: "OBSOLETE. The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral to phagophore assembly site membrane" NARROW []
synonym: "phagophore assembly site integral membrane protein" RELATED []
is_obsolete: true
replaced_by: GO:0034045

[Term]
id: GO:0097635
name: obsolete extrinsic component of autophagosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "autophagic vacuole peripheral membrane" RELATED []
synonym: "extrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy]
synonym: "extrinsic to autophagic vacuole membrane" EXACT []
is_obsolete: true
consider: GO:0000421

[Term]
id: GO:0097636
name: obsolete intrinsic component of autophagosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the autophagosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:autophagy, GOC:mf]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy]
synonym: "intrinsic to autophagic vacuole membrane" NARROW []
is_obsolete: true
replaced_by: GO:0000421

[Term]
id: GO:0097637
name: obsolete integral component of autophagosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the autophagosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:autophagy, GOC:mf]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "autophagic vacuole integral membrane protein" RELATED []
synonym: "integral component of autophagic vacuole membrane" EXACT [GOC:autophagy]
synonym: "integral to autophagic vacuole membrane" NARROW []
is_obsolete: true
replaced_by: GO:0000421

[Term]
id: GO:0097638
name: L-arginine import across plasma membrane
namespace: biological_process
alt_id: GO:0090467
alt_id: GO:1902765
def: "The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
synonym: "arginine import" BROAD []
synonym: "L-arginine import into cell" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0097639
name: L-lysine import across plasma membrane
namespace: biological_process
alt_id: GO:1903410
def: "The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
synonym: "L-lysine import into cell" EXACT []
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1903401 ! L-lysine transmembrane transport

[Term]
id: GO:0097640
name: L-ornithine import across plasma membrane
namespace: biological_process
alt_id: GO:1903411
def: "The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
synonym: "L-ornithine import into cell" EXACT []
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1903352 ! L-ornithine transmembrane transport

[Term]
id: GO:0097641
name: alpha-ketoglutarate-dependent xanthine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate." [GOC:vw, PMID:15948966, PMID:17429948, RHEA:43120]
synonym: "2-oxoglutarate-dependent xanthine dioxygenase activity" EXACT []
synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity" RELATED []
synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity" RELATED []
xref: RHEA:43120
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0097642
name: calcitonin family receptor activity
namespace: molecular_function
def: "Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity." [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0097643
name: amylin receptor activity
namespace: molecular_function
def: "Combining with amylin to initiate a change in cell activity." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0097642 ! calcitonin family receptor activity

[Term]
id: GO:0097644
name: calcitonin family binding
namespace: molecular_function
def: "Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))." [GOC:bhm, InterPro:IPR021116, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0097645
name: amylin binding
namespace: molecular_function
def: "Binding to amylin." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0097644 ! calcitonin family binding

[Term]
id: GO:0097646
name: calcitonin family receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
synonym: "calcitonin family receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0097647
name: amylin receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
synonym: "amilyn receptor signalling pathway" EXACT []
is_a: GO:0097646 ! calcitonin family receptor signaling pathway

[Term]
id: GO:0097648
name: G protein-coupled receptor complex
namespace: cellular_component
def: "A protein complex that contains G protein-coupled receptors." [GOC:bhm]
synonym: "G-protein coupled receptor complex" EXACT []
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0097649
name: A axonemal microtubule
namespace: cellular_component
def: "A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule." [GOC:cilia, ISBN:0716731363]
synonym: "A tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097545 ! axonemal doublet microtubule

[Term]
id: GO:0097650
name: B axonemal microtubule
namespace: cellular_component
def: "An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet." [GOC:cilia, ISBN:0716731363]
synonym: "B tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097545 ! axonemal doublet microtubule

[Term]
id: GO:0097651
name: phosphatidylinositol 3-kinase complex, class I
namespace: cellular_component
def: "A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488]
synonym: "class I phosphatidylinositol 3-kinase complex" EXACT []
synonym: "class I PI3K complex" EXACT []
is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex

[Term]
id: GO:0097652
name: phosphatidylinositol 3-kinase complex, class II
namespace: cellular_component
def: "A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488]
synonym: "class II phosphatidylinositol 3-kinase complex" EXACT []
synonym: "class II PI3K complex" EXACT []
is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex

[Term]
id: GO:0097653
name: unencapsulated part of cell
namespace: cellular_component
def: "The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures." [GOC:curators]
synonym: "non-encapsulated part of cell" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0097654
name: platelet SNARE complex
namespace: cellular_component
def: "A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4." [GOC:bhm, PMID:12130530, PMID:19450911]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0097655
name: serpin family protein binding
namespace: molecular_function
def: "Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors." [GOC:mr, InterPro:IPR000215, PMID:16737556]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0097656
name: cell-cell self recognition
namespace: biological_process
def: "A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development." [GOC:pf, PMID:21700835, PMID:23910661]
comment: Examples are the membrane proteins TgrB1 and TgrC1 in the social amoeba Dictyostelium discoideum.
synonym: "kin discrimination" RELATED []
synonym: "kin recognition" BROAD []
synonym: "self recognition" BROAD []
is_a: GO:0009988 ! cell-cell recognition

[Term]
id: GO:0097657
name: 3',5'-nucleotide bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate." [GOC:jh2, PMID:24401123, RHEA:43532]
xref: EC:3.1.3.97
xref: RHEA:43532
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0097658
name: Asi complex
namespace: cellular_component
def: "A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p." [GOC:mcc, PMID:25236469]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005637 ! nuclear inner membrane

[Term]
id: GO:0097659
name: obsolete nucleic acid-templated transcription
namespace: biological_process
def: "OBSOLETE. The synthesis of an RNA transcript from a nucleic acid template (DNA or RNA)." [GOC:pr, GOC:txnOH, GOC:vw]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
consider: GO:0006366

[Term]
id: GO:0097660
name: SCF-Cdc4 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:9346238]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097661
name: SCF-Ctf13 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097662
name: SCF-Das1 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097663
name: SCF-Dia2/Pof3 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097664
name: SCF-Grr1/Pof2 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe)." [GOC:jd, GOC:vw, PMID:10213692, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097665
name: SCF-Mdm30 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097666
name: SCF-Met30/Pof1 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe)." [GOC:jd, GOC:vw, PMID:15147268, PMID:9499404]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097667
name: SCF-Rcy1/Pof6 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097668
name: SCF-Saf1/Pof9 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe)." [GOC:jd, GOC:vw, PMID:11283612, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097669
name: SCF-Skp2 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097670
name: SCF-Ufo1/Pof10 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097671
name: SCF-YDR131C ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097672
name: SCF-Pof5 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
synonym: "SCF-YDR306C ubiquitin ligase complex" RELATED []
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097673
name: SCF-Ucc1 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994, PMID:25982115]
synonym: "SCF-YLR224W ubiquitin ligase complex" EXACT [PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097674
name: SCF-YLR352W ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:19882662]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097675
name: SCF-Hrt3/Pof7 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0097676
name: obsolete histone H3-K36 dimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone." [GOC:lb, PMID:21187428]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0097677
name: STAT family protein binding
namespace: molecular_function
def: "Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses." [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978]
synonym: "signal transducers and activators of transcription family protein binding" EXACT []
is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding

[Term]
id: GO:0097678
name: SOCS family protein binding
namespace: molecular_function
def: "Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions." [GOC:mr, InterPro:IPR028413, PMID:23885323, PMID:24705897]
synonym: "suppressor of cytokine signaling family protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0097680
name: double-strand break repair via classical nonhomologous end joining
namespace: biological_process
def: "An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining)." [GOC:rph, PMID:18584027]
synonym: "C-NHEJ" RELATED []
synonym: "canonical nonhomologous end joining" EXACT []
is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining

[Term]
id: GO:0097681
name: double-strand break repair via alternative nonhomologous end joining
namespace: biological_process
def: "An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining]
synonym: "A-NHEJ" RELATED []
synonym: "alt-NHEJ" RELATED []
synonym: "double-strand break repair via microhomology-mediated end joining" EXACT []
synonym: "MMEJ" RELATED []
is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining

[Term]
id: GO:0097682
name: intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:ha, PMID:24375408]
synonym: "intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity" BROAD []
synonym: "intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity" EXACT []
is_a: GO:0005217 ! intracellularly ligand-gated monoatomic ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0097683
name: dinoflagellate apex
namespace: cellular_component
def: "The anterior most point of a dinoflagellate epicone." [GOC:at, http://tolweb.org/Dinoflagellates/2445, PMID:7002229, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "apex" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097613 ! dinoflagellate epicone

[Term]
id: GO:0097684
name: dinoflagellate antapex
namespace: cellular_component
def: "The anterior most point of a dinoflagellate hypocone." [GOC:at, http://tolweb.org/Dinoflagellates/2445, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "antapex" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097614 ! dinoflagellate hypocone

[Term]
id: GO:0097685
name: dinoflagellate apical groove
namespace: cellular_component
def: "A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex." [GOC:at, http://tolweb.org/Dinoflagellates/2445, PMID:20561119, Wikipedia:Dinoflagellate#Morphology]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "apical groove" BROAD []
is_a: GO:0097610 ! cell surface furrow
relationship: part_of GO:0097613 ! dinoflagellate epicone

[Term]
id: GO:0097686
name: dinoflagellate apical horn
namespace: cellular_component
def: "A horn-shaped dinoflagellate apex found in thecate species." [GOC:at, PMID:7002229]
is_a: GO:0097683 ! dinoflagellate apex

[Term]
id: GO:0097687
name: dinoflagellate antapical horn
namespace: cellular_component
def: "A horn-shaped dinoflagellate antapex found in thecate species." [GOC:at, PMID:7002229]
is_a: GO:0097684 ! dinoflagellate antapex

[Term]
id: GO:0097688
name: glutamate receptor clustering
namespace: biological_process
def: "The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane." [GOC:krc, PMID:19723286]
synonym: "glutamatergic receptor clustering" EXACT []
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering

[Term]
id: GO:0097690
name: iron ion transmembrane transporter inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter." [GOC:BHF, GOC:kom, PMID:15514116]
comment: An example of this is human hepcidin (UniProt symbol P81172), which regulates iron transport out of cells (see PMID:15514116).
synonym: "iron channel inhibitor activity" EXACT []
is_a: GO:0141110 ! transporter inhibitor activity

[Term]
id: GO:0097691
name: bacterial extracellular vesicle
namespace: cellular_component
def: "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells." [GOC:aa, PMID:25704309]
is_a: GO:1903561 ! extracellular vesicle

[Term]
id: GO:0097692
name: obsolete histone H3-K4 monomethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone." [GOC:jh2, PMID:26320581]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0097693
name: ocelloid
namespace: cellular_component
def: "Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids." [GOC:ar, PMID:26131935]
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0097694
name: establishment of RNA localization to telomere
namespace: biological_process
def: "The directed movement of RNA to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]
synonym: "establishment of RNA localisation to telomere" EXACT []
is_a: GO:0051236 ! establishment of RNA localization

[Term]
id: GO:0097695
name: establishment of protein-containing complex localization to telomere
namespace: biological_process
def: "The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]
synonym: "establishment of macromolecular complex localisation to telomere" EXACT []
synonym: "establishment of macromolecular complex localization to telomere" RELATED []
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0097696
name: cell surface receptor signaling pathway via STAT
namespace: biological_process
def: "An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:rjd, PMID:21534947, PMID:24587195]
comment: In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins.
synonym: "kinase activated-STAT cascade" EXACT []
synonym: "kinase-STAT cascade" EXACT []
synonym: "receptor signaling pathway via STAT" EXACT []
synonym: "STAT signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0097697
name: tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:26681692, RHEA:54080]
synonym: "tRNA 5-carboxymethoxyuridine methyltransferase activity" RELATED []
xref: RHEA:54080
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity

[Term]
id: GO:0097698
name: telomere maintenance via base-excision repair
namespace: biological_process
def: "A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:24703901]
is_a: GO:0006284 ! base-excision repair
is_a: GO:0043247 ! telomere maintenance in response to DNA damage

[Term]
id: GO:0097699
name: vascular endothelial cell response to fluid shear stress
namespace: biological_process
def: "Any response to fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to fluid shear stress" EXACT []
is_a: GO:0071498 ! cellular response to fluid shear stress

[Term]
id: GO:0097700
name: vascular endothelial cell response to laminar fluid shear stress
namespace: biological_process
def: "Any response to laminar fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to laminar fluid shear stress" EXACT []
is_a: GO:0071499 ! cellular response to laminar fluid shear stress
is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress

[Term]
id: GO:0097701
name: response to pulsatile fluid shear stress
namespace: biological_process
def: "Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0034405 ! response to fluid shear stress

[Term]
id: GO:0097702
name: response to oscillatory fluid shear stress
namespace: biological_process
def: "Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0034405 ! response to fluid shear stress

[Term]
id: GO:0097703
name: cellular response to pulsatile fluid shear stress
namespace: biological_process
def: "Any response to pulsatile fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0071498 ! cellular response to fluid shear stress
is_a: GO:0097701 ! response to pulsatile fluid shear stress

[Term]
id: GO:0097704
name: cellular response to oscillatory fluid shear stress
namespace: biological_process
def: "Any response to oscillatory fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0071498 ! cellular response to fluid shear stress
is_a: GO:0097702 ! response to oscillatory fluid shear stress

[Term]
id: GO:0097705
name: vascular endothelial cell response to pulsatile fluid shear stress
namespace: biological_process
def: "Any response to pulsatile fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to pulsatile fluid shear stress" EXACT []
is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress
is_a: GO:0097703 ! cellular response to pulsatile fluid shear stress

[Term]
id: GO:0097706
name: vascular endothelial cell response to oscillatory fluid shear stress
namespace: biological_process
def: "Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to oscillatory fluid shear stress" EXACT []
is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress
is_a: GO:0097704 ! cellular response to oscillatory fluid shear stress

[Term]
id: GO:0097707
name: ferroptosis
namespace: biological_process
def: "A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes." [GOC:mtg_apoptosis, PMID:25236395, PMID:26794443]
synonym: "iron-dependent programmed cell death" RELATED []
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0097708
name: intracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the intracellular region." [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0097709
name: connective tissue replacement
namespace: biological_process
def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:25590961]
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0097710
name: viral terminase, small subunit
namespace: cellular_component
def: "The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit." [GOC:ch, GOC:jh2, PMID:18687036]
comment: This term should only be used when the small subunit consists of more than one polypeptide.
synonym: "virus terminase, small subunit" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0043493 ! viral terminase complex

[Term]
id: GO:0097711
name: ciliary basal body-plasma membrane docking
namespace: biological_process
def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235]
comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella.
synonym: "anchoring of the basal body to the plasma membrane" RELATED []
synonym: "ciliary basal body docking" EXACT []
is_a: GO:0140056 ! organelle localization by membrane tethering
relationship: part_of GO:0060271 ! cilium assembly

[Term]
id: GO:0097712
name: vesicle targeting, trans-Golgi to periciliary membrane compartment
namespace: biological_process
def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645]
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0060271 ! cilium assembly

[Term]
id: GO:0097713
name: dolichol-phosphate-mannose synthase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of dolichol-phosphate-mannose synthase." [GOC:vw, PMID:10835346]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0097714
name: response to viscosity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [GOC:sl, PMID:7061416]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0097715
name: cellular response to viscosity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [GOC:sl, PMID:7061416]
is_a: GO:0071214 ! cellular response to abiotic stimulus
is_a: GO:0097714 ! response to viscosity

[Term]
id: GO:0097716
name: copper ion transport across blood-brain barrier
namespace: biological_process
def: "The directed movement of copper (Cu) ions passing through the blood-brain barrier." [GOC:sl, PMID:24614235]
synonym: "copper ion transport across BBB" RELATED []
is_a: GO:0006825 ! copper ion transport
is_a: GO:0150104 ! transport across blood-brain barrier

[Term]
id: GO:0097717
name: copper ion transport across blood-cerebrospinal fluid barrier
namespace: biological_process
def: "The directed movement of copper (Cu) ions passing through the blood-cerebrospinal fluid barrier." [GOC:sl, PMID:24614235]
synonym: "copper ion transport across BCB" RELATED []
synonym: "copper ion transport across BCSFB" EXACT []
synonym: "copper ion transport across blood-CSF barrier" EXACT []
synonym: "copper ion transport across blood/cerebrospinal fluid barrier" EXACT []
synonym: "copper ion transport across blood/CSF barrier" EXACT []
is_a: GO:0006825 ! copper ion transport
is_a: GO:0150195 ! transport across blood-cerebrospinal fluid barrier

[Term]
id: GO:0097718
name: disordered domain specific binding
namespace: molecular_function
def: "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]
synonym: "disordered protein domain specific binding" RELATED []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0097719
name: neural tissue regeneration
namespace: biological_process
def: "The regrowth of neural tissue following its loss or destruction." [Wikipedia:Neuroregeneration]
synonym: "neuroregeneration" RELATED []
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0097720
name: calcineurin-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]
synonym: "calcineurin signaling" RELATED []
synonym: "calcineurin-mediated signalling" EXACT []
is_a: GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0097721
name: ciliary vesicle
namespace: cellular_component
def: "A Golgi-derived vesicle to which the ciliary basal body docks via its transitional fibers. Its membrane is compositionally distinct from Golgi membranes, and will become the ciliary membrane once the ciliary vesicle is fused to the plasma membrane. The ciliary vesicle is thought to be formed by multiple smaller vesicles that attach to the transitional fibers and then fuse to form a larger vesicle." [GOC:cilia, PMID:13978319, PMID:25686250]
synonym: "CV" RELATED [PMID:2568625]
synonym: "primary ciliary vesicle" EXACT [PMID:20427320]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0097722
name: sperm motility
namespace: biological_process
def: "Any process involved in the controlled movement of a sperm cell." [GOC:cilia, GOC:krc]
subset: gocheck_do_not_annotate
synonym: "sperm movement" EXACT []
is_a: GO:0022414 ! reproductive process
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0097723
name: amoeboid sperm motility
namespace: biological_process
def: "Any process involved in the controlled movement of an amoeboid sperm cell." [GOC:cilia, GOC:krc]
synonym: "ameboid sperm motility" EXACT []
synonym: "ameboid sperm movement" EXACT []
synonym: "amoeboid sperm movement" EXACT []
is_a: GO:0097722 ! sperm motility

[Term]
id: GO:0097725
name: obsolete histone H3-K79 dimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of two methyl groups to lysine at position 79 of the histone." [GOC:hbye, PMID:27541139]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K79 dimethylation" EXACT []
synonym: "histone lysine H3 K79 dimethylation" EXACT []
is_obsolete: true
consider: GO:0031151

[Term]
id: GO:0097726
name: LEM domain binding
namespace: molecular_function
def: "Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)." [GOC:rz, InterPro:IPR003887, PMID:22399800]
synonym: "lamina-associated polypeptide, emerin, MAN1 domain binding" EXACT []
synonym: "LAP2, emerin, MAN1 domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0097727
name: blepharoplast
namespace: cellular_component
def: "An intracellular non-membrane-bounded organelle found in multi-ciliated sperm cells of some primitive land plants, and consisting of many radially arranged ninefold symmetric cylinders. The blepharoplast is involved in de novo formation of multiple centrioles; it enlarges and then disintegrates into many procentrioles, which elongate and ultimately nucleate cilia on the surface of the sperm cell." [GOC:cilia, GOC:tb, PMID:22691130, PMID:25047614]
comment: The blepharoplast should not be confused with a basal body; rather, it acts as the precursor assembly zone for multiple basal bodies.
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0097728
name: 9+0 motile cilium
namespace: cellular_component
def: "A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:10330409, PMID:22118931]
comment: This type of cilia may be present in solitary (classic nodal cilia in embryonic nodes) or in multiple copies (e.g. in the choroid plexus epithelium).
synonym: "motile 9+0 cilium" EXACT []
synonym: "nodal cilium" NARROW []
is_a: GO:0031514 ! motile cilium

[Term]
id: GO:0097729
name: 9+2 motile cilium
namespace: cellular_component
def: "A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]
comment: This type of cilia may be present in solitary (so-called flagella, e.g. in sperm) or in multiple copies (so-called conventional motile cilia, e.g. in tracheal epithelium, ependyma or oviduct epithelium).
synonym: "conventional motile cilium" NARROW []
synonym: "motile 9+2 cilium" EXACT []
synonym: "sperm flagellum" NARROW []
is_a: GO:0031514 ! motile cilium

[Term]
id: GO:0097730
name: non-motile cilium
namespace: cellular_component
alt_id: GO:0031513
def: "A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]
synonym: "immotile cilium" EXACT []
synonym: "immotile primary cilium" RELATED []
synonym: "nonmotile cilium" EXACT []
synonym: "nonmotile primary cilia" RELATED []
synonym: "nonmotile primary cilium" RELATED []
synonym: "sensory cilium" RELATED []
is_a: GO:0005929 ! cilium

[Term]
id: GO:0097731
name: 9+0 non-motile cilium
namespace: cellular_component
def: "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:22118931]
comment: This type of cilia may be present in solitary (authentic primary cilia in many cell types) or in multiple copies (e.g. in Grueneberg ganglion neurons).
synonym: "9+0 immotile cilium" EXACT []
synonym: "non-motile 9+0 cilium" EXACT []
synonym: "primary cilium" NARROW []
is_a: GO:0097730 ! non-motile cilium

[Term]
id: GO:0097732
name: 9+2 non-motile cilium
namespace: cellular_component
def: "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:21307074, PMID:22118931]
comment: This type of cilia may be present in solitary (e.g. in inner hair cells) or in multiple copies (e.g. in olfactory neurons).
synonym: "9+2 immotile cilium" RELATED []
synonym: "non-motile 9+2 cilium" EXACT []
is_a: GO:0097730 ! non-motile cilium

[Term]
id: GO:0097733
name: photoreceptor cell cilium
namespace: cellular_component
def: "A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment." [GOC:cilia, Wikipedia:Photoreceptor_cell#Histology]
synonym: "photoreceptor cilium" EXACT []
is_a: GO:0043005 ! neuron projection
is_a: GO:0097731 ! 9+0 non-motile cilium

[Term]
id: GO:0097734
name: extracellular exosome biogenesis
namespace: biological_process
def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495]
synonym: "exosome assembly or secretion" EXACT []
synonym: "exosome biogenesis" EXACT []
synonym: "exosome production" EXACT []
synonym: "ILV assembly" RELATED []
synonym: "intraluminal vesicle assembly" RELATED []
is_a: GO:0140112 ! extracellular vesicle biogenesis

[Term]
id: GO:0097735
name: DIM/DIP cell wall layer
namespace: cellular_component
def: "A section of the Actinobacterium-type cell wall composed of (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate, diphthioceranate and other compounds." [GOC:pr]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009275 ! Gram-positive-bacterium-type cell wall

[Term]
id: GO:0097736
name: aerial mycelium formation
namespace: biological_process
def: "The process by which hyphae grow in an upward or outward direction from the surface of the substrate; from there, propagative spores develop in or on characteristic structures that are distinctive of some fungal and bacterial species. The species that form an aerial mycelium develop conidiophores at the ends of the aerial hyphae." [GOC:di, PMID:12832397]
synonym: "aerial hyphal growth" RELATED []
synonym: "fertile mycelium formation" RELATED []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0097737
name: acquisition of mycelium reproductive competence
namespace: biological_process
def: "A maturation process by which an organism acquires the ability to reproduce. In fungi, reproductive competence only occurs in a population of filamentous cells that form a mycelium." [GOC:di, PMID:23864594]
synonym: "mycelium developmental competence" RELATED []
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0097738
name: substrate mycelium formation
namespace: biological_process
def: "The process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate." [GOC:di, PMID:10021365]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0097739
name: negative regulation of ferrichrome biosynthetic process in response to iron
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus." [GOC:al]
is_a: GO:1905569 ! negative regulation of ferrichrome biosynthetic process
relationship: part_of GO:0071281 ! cellular response to iron ion

[Term]
id: GO:0097740
name: paraflagellar rod
namespace: cellular_component
def: "A large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signaling and metabolism, and in calcium signaling." [GOC:cilia, PMID:19879876, PMID:26199333, PMID:26688619]
synonym: "PFR" RELATED []
is_a: GO:0099080 ! supramolecular complex
relationship: part_of GO:0097729 ! 9+2 motile cilium

[Term]
id: GO:0097741
name: mastigoneme
namespace: cellular_component
def: "A hair-like structure covering the flagella found in some algae (heterokonts and cryptophytes). It is approximately 15 nm in diameter, and usually consist of a tubular shaft that itself terminates in smaller hairs. It is composed of glycoproteins and, likely, carbohydrates. Mastigonemes may assist in locomotion by increasing the surface area of a flagellum." [GOC:cilia, PMID:943397, Wikipedia:Mastigoneme]
is_a: GO:0099080 ! supramolecular complex
relationship: part_of GO:0031514 ! motile cilium

[Term]
id: GO:0097742
name: de novo centriole assembly
namespace: biological_process
def: "Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects." [GOC:cilia, PMID:25047614, PMID:25291643]
synonym: "acentriolar basal body biogenesis" RELATED []
synonym: "de novo basal body amplification" RELATED []
synonym: "de novo basal body assembly" RELATED []
synonym: "de novo basal body biogenesis" RELATED []
synonym: "de novo basal body generation" RELATED []
synonym: "de novo centriole amplification" RELATED []
synonym: "de novo ciliary basal body assembly" RELATED []
synonym: "multiciliation" RELATED []
synonym: "multiciliogenesis" RELATED []
is_a: GO:0098534 ! centriole assembly

[Term]
id: GO:0097743
name: de novo centriole assembly via blepharoplast
namespace: biological_process
def: "A de novo centriole assembly process observed in multi-ciliated sperm cells of some primitive land plants, and where centrioles are formed from a blepharoplast, ultimately giving rise to multiple cilia on the sperm surface." [GOC:cilia, PMID:25047614]
synonym: "multiciliation" RELATED []
synonym: "multiciliogenesis" RELATED []
is_a: GO:0097742 ! de novo centriole assembly

[Term]
id: GO:0097744
name: renal urate salt excretion
namespace: biological_process
def: "The elimination of urate salt or uric acid from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:jl, PMID:25287933, PMID:3906799, Wikipedia:Renal_physiology#Secretion]
synonym: "urate excretion" BROAD []
synonym: "urate salt excretion" BROAD []
is_a: GO:0097254 ! renal tubular secretion

[Term]
id: GO:0097745
name: mitochondrial tRNA 5'-end processing
namespace: biological_process
def: "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:pf, PMID:21307182, PMID:26143376, PMID:27484477]
is_a: GO:0000964 ! mitochondrial RNA 5'-end processing
is_a: GO:0090646 ! mitochondrial tRNA processing
is_a: GO:0099116 ! tRNA 5'-end processing

[Term]
id: GO:0097746
name: blood vessel diameter maintenance
namespace: biological_process
alt_id: GO:0042312
alt_id: GO:0050880
def: "Any process that modulates the diameter of blood vessels." [GOC:pr]
synonym: "blood vessel diameter homeostasis" EXACT []
synonym: "regulation of blood vessel diameter" EXACT []
synonym: "regulation of blood vessel size" RELATED []
synonym: "regulation of vasodilatation" RELATED []
synonym: "regulation of vasodilation" RELATED []
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0035296 ! regulation of tube diameter
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0097747
name: RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [GOC:pf]
is_a: GO:0016779 ! nucleotidyltransferase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0097748
name: 3'-5' RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end." [GOC:pf, PMID:22456265, PMID:27484477, PMID:30917604]
xref: RHEA:57528
is_a: GO:0097747 ! RNA polymerase activity

[Term]
id: GO:0097749
name: membrane tubulation
namespace: biological_process
def: "A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules)." [GOC:pr]
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0097750
name: endosome membrane tubulation
namespace: biological_process
def: "A membrane tubulation process occurring in an endosome membrane." [GOC:bc, GOC:PARL, PMID:26911690]
synonym: "endosomal membrane tubulation" EXACT []
is_a: GO:0007032 ! endosome organization
is_a: GO:0097749 ! membrane tubulation

[Term]
id: GO:0097751
name: spore-bearing structure formation
namespace: biological_process
def: "The process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores." [GOC:di]
synonym: "sporangium formation" BROAD []
synonym: "sporophore formation" EXACT []
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0075259 ! spore-bearing structure development

[Term]
id: GO:0097752
name: regulation of DNA stability
namespace: biological_process
def: "Any process that modulates the stability of DNA." [GOC:pr]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0097753
name: membrane bending
namespace: biological_process
def: "A membrane organization process resulting in the bending of a membrane." [GOC:krc, GOC:pr, GOC:vw, Wikipedia:Membrane_curvature]
synonym: "membrane curvature" RELATED []
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0097754
name: clathrin-mediated membrane bending
namespace: biological_process
def: "A membrane bending process mediated by clathrin." [GOC:pr, Wikipedia:Membrane_curvature]
is_a: GO:0097753 ! membrane bending

[Term]
id: GO:0097755
name: obsolete positive regulation of blood vessel diameter
namespace: biological_process
def: "OBSOLETE. Any process that increases the diameter of blood vessels." [GOC:pr]
comment: This term was obsoleted because it corresponded to an existing term, GO:0042311 ; vasodilation.
synonym: "positive regulation of vasodilation" RELATED []
is_obsolete: true

[Term]
id: GO:0097756
name: obsolete negative regulation of blood vessel diameter
namespace: biological_process
def: "OBSOLETE. Any process that decreases the diameter of blood vessels." [GOC:pr]
comment: This term was obsoleted because it corresponded to an existing term, GO:0042310 ; vasocontriction.
synonym: "negative regulation of vasodilation" RELATED []
is_obsolete: true

[Term]
id: GO:0098001
name: receptor-mediated bacteriophage reversible attachment to host cell
namespace: biological_process
def: "Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection." [GOC:bm]
comment: This process was historically defined by the release, by Waring blending or sonication, by dilution and centrifugation, or by filtration and washing, of infective virions from their complexes with cells, thus contrary to what is observed after irreversible adsorption.
synonym: "phage reversible adsorption" RELATED [GOC:bm]
synonym: "reversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl]
is_a: GO:0098671 ! adhesion receptor-mediated virion attachment to host cell

[Term]
id: GO:0098002
name: receptor-mediated bacteriophage irreversible attachment to host cell
namespace: biological_process
def: "The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell." [GOC:bm]
synonym: "irreversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl]
synonym: "phage irreversible adsorption" RELATED [GOC:bm]
is_a: GO:0098670 ! entry receptor-mediated virion attachment to host cell

[Term]
id: GO:0098003
name: viral tail assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail." [GOC:bm, VZ:3955]
synonym: "bacteriophage tail assembly" NARROW [GOC:bm]
synonym: "virus tail assembly" EXACT [GOC:bf, GOC:jl]
xref: VZ:3955 "Viral tail assembly"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0098004
name: virus tail fiber assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber." [GOC:bm, VZ:3956]
xref: VZ:3956 "Viral tail fiber assembly"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0098003 ! viral tail assembly

[Term]
id: GO:0098005
name: viral head-tail joining
namespace: biological_process
def: "Process by which virus heads and tails are attached to each other." [GOC:bm]
synonym: "phage head tail joining" NARROW [GOC:bm]
synonym: "virus head-tail joining" EXACT [GOC:bf, GOC:jl]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0098006
name: viral DNA genome packaging, headful
namespace: biological_process
def: "The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full." [GOC:bm]
comment: Generalized transducing phages usually use this mode of DNA packaging.
synonym: "phage headful packaging" NARROW [GOC:bm]
is_a: GO:0019073 ! viral DNA genome packaging

[Term]
id: GO:0098009
name: viral terminase, large subunit
namespace: cellular_component
def: "The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit." [GOC:bm, GOC:ch, GOC:jh2, PMID:18687036]
comment: This term should only be used when the large subunit consists of more than one polypeptide.
synonym: "virus terminase, large subunit" EXACT []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0043493 ! viral terminase complex

[Term]
id: GO:0098015
name: virus tail
namespace: cellular_component
def: "Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell." [GOC:bm, VZ:3958]
comment: Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell.
synonym: "bacteriophage tail" NARROW [GOC:bm]
synonym: "viral tail" RELATED [GOC:bf]
xref: VZ:3958 "Viral tail protein"
is_a: GO:0044423 ! virion component

[Term]
id: GO:0098017
name: viral capsid, major subunit
namespace: cellular_component
def: "The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits." [GOC:bm]
synonym: "major capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl]
synonym: "major head protein" RELATED []
is_a: GO:0046727 ! capsomere

[Term]
id: GO:0098018
name: viral capsid, minor subunit
namespace: cellular_component
def: "The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits." [GOC:bm]
synonym: "minor capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl]
synonym: "minor head protein" RELATED []
is_a: GO:0046727 ! capsomere

[Term]
id: GO:0098019
name: obsolete virus tail, major subunit
namespace: cellular_component
def: "OBSOLETE. The part of the viral tail that comprises the most common subunit type." [GOC:bm]
comment: The reason for obsoletion is that these are not precise structures: major (most abundant) and minor subunits of viral tails vary in different viruses/phages.
synonym: "major tail protein" RELATED []
is_obsolete: true

[Term]
id: GO:0098020
name: obsolete virus tail, minor subunit
namespace: cellular_component
def: "OBSOLETE. The part of the viral tail that comprises the least common subunit type." [GOC:bm]
comment: The reason for obsoletion is that these are not precise structures: major (most abundant) and minor subunits of viral tails vary in different viruses/phages.
synonym: "bacteriophage minor protein subunit" NARROW [GOC:bm]
synonym: "minor tail protein" RELATED [GOC:bm]
is_obsolete: true

[Term]
id: GO:0098021
name: viral capsid, decoration
namespace: cellular_component
def: "Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential." [GOC:bm, VZ:4398]
synonym: "decoration protein" RELATED [GOC:bm]
xref: VZ:4398 "Capsid decoration protein"
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0098022
name: viral capsid, fiber
namespace: cellular_component
def: "A type of capsid decoration composed of fiber structures." [GOC:bm]
synonym: "head/capsid fiber" RELATED [GOC:bm]
is_a: GO:0098021 ! viral capsid, decoration

[Term]
id: GO:0098023
name: virus tail, tip
namespace: cellular_component
def: "The basal end of the virus tail, which is used by the virus to attach to the host cell." [GOC:bm]
synonym: "bacteriophage tail tip" NARROW [GOC:bm]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0098015 ! virus tail

[Term]
id: GO:0098024
name: virus tail, fiber
namespace: cellular_component
def: "The fibrous region of the virus tail used to scan, recognize and attach to the host cell." [GOC:bm, VZ:4416]
comment: For tailed bacteriophages, fibers typically bind to particular Lipopolysaccharide (LPS), polysaccharide or protein receptors on the cell surface.
synonym: "bacteriophage tail fiber" NARROW [GOC:bm]
xref: VZ:4416 "Viral tail fiber protein"
is_a: GO:0044423 ! virion component
relationship: part_of GO:0098015 ! virus tail

[Term]
id: GO:0098025
name: virus tail, baseplate
namespace: cellular_component
def: "Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached." [GOC:bm, VZ:3957]
comment: Tail fibers are often attached to the baseplate of Caudovirales (tailed bacteriophages with dsDNA genomes). Sometimes referred to as the tail tip or tip structure in Siphoviridae.
synonym: "bacteriophage baseplate" NARROW [GOC:bm]
synonym: "tail structure" RELATED [GOC:bm]
synonym: "tail tip" RELATED [GOC:bm]
xref: VZ:3957 "Viral baseplate protein"
is_a: GO:0044423 ! virion component
relationship: part_of GO:0098015 ! virus tail

[Term]
id: GO:0098026
name: virus tail, tube
namespace: cellular_component
def: "The internal tube of the tail of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [PMID:33188213, VZ:3960]
comment: Applies in particular the Myoviridae bacteriophages. Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell.
synonym: "bacteriophage tail tube" NARROW [GOC:bm]
xref: VZ:3960 "Viral tail tube protein"
is_a: GO:0044423 ! virion component
relationship: part_of GO:0098015 ! virus tail

[Term]
id: GO:0098027
name: virus tail, sheath
namespace: cellular_component
def: "The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm." [GOC:bm, VZ:3959]
synonym: "bacteriophage tail sheath" NARROW [GOC:bm]
xref: VZ:3959 "Viral tail sheath protein"
is_a: GO:0044423 ! virion component
relationship: part_of GO:0098015 ! virus tail

[Term]
id: GO:0098028
name: virus tail, shaft
namespace: cellular_component
def: "The tube of the non-contractile tails of some viruses." [GOC:bm]
comment: This term applies in particular to the Siphoviridae bacteriophages, where the shaft is the channel for DNA translocation into the host cytoplasm.
synonym: "bacteriophage tail shaft" NARROW [GOC:bm]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0098015 ! virus tail

[Term]
id: GO:0098029
name: icosahedral viral capsid, spike
namespace: cellular_component
def: "A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell." [GOC:bm]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0098030
name: icosahedral viral capsid, neck
namespace: cellular_component
def: "A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae)." [GOC:bm]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0098031
name: icosahedral viral capsid, collar
namespace: cellular_component
def: "A small disk located at the base of some icosahedral virus capsids." [GOC:bm]
is_a: GO:0044423 ! virion component
relationship: part_of GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0098032
name: icosahedral viral capsid, collar fiber
namespace: cellular_component
def: "A fiber attached to the collar structure of some icosahedral viral capsids." [GOC:bm]
is_a: GO:0098022 ! viral capsid, fiber
relationship: part_of GO:0098031 ! icosahedral viral capsid, collar

[Term]
id: GO:0098033
name: icosahedral viral capsid, neck fiber
namespace: cellular_component
def: "A fiber attached to the neck at the base of some icosahedral viral capsids." [GOC:bm]
is_a: GO:0098022 ! viral capsid, fiber
relationship: part_of GO:0098030 ! icosahedral viral capsid, neck

[Term]
id: GO:0098035
name: viral DNA genome packaging via site-specific sequence recognition
namespace: biological_process
def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase." [GOC:bm]
is_a: GO:0019073 ! viral DNA genome packaging

[Term]
id: GO:0098036
name: viral DNA genome packaging, 3' extended cos packaging
namespace: biological_process
def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends." [GOC:bm]
is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition

[Term]
id: GO:0098037
name: viral DNA genome packaging, 5' extended cos packaging
namespace: biological_process
def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends." [GOC:bm]
is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition

[Term]
id: GO:0098038
name: non-replicative DNA transposition
namespace: biological_process
def: "Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition." [GOC:bm, PMID:2553270]
synonym: "cut-and-paste transposition" EXACT [GOC:bm]
synonym: "non-replicative transposition, DNA-mediated" EXACT []
is_a: GO:0006313 ! DNA transposition

[Term]
id: GO:0098039
name: replicative DNA transposition
namespace: biological_process
def: "Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition." [GOC:bm, PMID:10540284, PMID:1660177]
synonym: "copy-and-paste transposition" EXACT [GOC:bm]
synonym: "replicative transposition, DNA-mediated" EXACT []
synonym: "transpositional DNA genome replication" EXACT []
is_a: GO:0006313 ! DNA transposition

[Term]
id: GO:0098045
name: virus baseplate assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a virus baseplate." [GOC:bm]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0098003 ! viral tail assembly

[Term]
id: GO:0098046
name: type V protein secretion system complex
namespace: cellular_component
def: "A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc)." [GOC:bf, GOC:bhm, PMID:15119822, PMID:15590781]
comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'.
synonym: "autotransporter system complex" NARROW [PMID:15590781, Wikipedia:Secretion]
synonym: "T5SS complex" EXACT [Wikipedia:Secretion]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0098061
name: viral capsid, internal space
namespace: cellular_component
def: "The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins." [GOC:bm]
synonym: "internal head protein" EXACT [GOC:bm]
is_a: GO:0044423 ! virion component

[Term]
id: GO:0098501
name: obsolete polynucleotide dephosphorylation
namespace: biological_process
def: "OBSOLETE. The process of removing one or more phosphate groups from a polynucleotide." [GOC:DOS]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0098502
name: obsolete DNA dephosphorylation
namespace: biological_process
def: "OBSOLETE. The process of removing one or more phosphate groups from a DNA molecule." [GOC:DOS]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0098503
name: obsolete DNA 3' dephosphorylation
namespace: biological_process
def: "OBSOLETE. The process of removing a 3' phosphate group from a DNA molecule." [GOC:DOS]
comment: This term was obsoleted because it represents a molecular function, and not a specific coordinated process.
is_obsolete: true

[Term]
id: GO:0098504
name: obsolete DNA 3' dephosphorylation involved in DNA repair
namespace: biological_process
def: "OBSOLETE. Any 3' DNA dephosphorylation that is involved in the process of DNA repair." [GOC:DOS, PMID:11729194]
comment: This term was obsoleted because it represents a molecular function, and not a specific coordinated process.
is_obsolete: true

[Term]
id: GO:0098505
name: G-rich strand telomeric DNA binding
namespace: molecular_function
def: "Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150]
is_a: GO:0043047 ! single-stranded telomeric DNA binding

[Term]
id: GO:0098506
name: polynucleotide 3' dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from the 3' end of a polynucleotide." [GOC:dos]
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0098507
name: polynucleotide 5' dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from the 5' end of a polynucleotide." [GOC:dos]
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0098508
name: endothelial to hematopoietic transition
namespace: biological_process
def: "The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium." [PMID:20154732, PMID:22521721]
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0060232 ! delamination

[Term]
id: GO:0098509
name: sensory perception of humidity
namespace: biological_process
def: "The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908, PMID:8650222]
comment: Note, this is not classified under 'detection of chemical stimulus' as there are various potential mechanisms of hygroperception including detection of mechanical stimulus.
synonym: "hygrosensory perception" EXACT [PMID:8650222]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0098510
name: sensory perception of high humidity
namespace: biological_process
def: "The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908]
is_a: GO:0098509 ! sensory perception of humidity

[Term]
id: GO:0098511
name: sensory perception of low humidity
namespace: biological_process
def: "The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908]
is_a: GO:0098509 ! sensory perception of humidity

[Term]
id: GO:0098512
name: detection of humidity stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity." [GOC:dos, PMID:8650222]
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0098513 ! detection of humidity
relationship: part_of GO:0098509 ! sensory perception of humidity

[Term]
id: GO:0098513
name: detection of humidity
namespace: biological_process
def: "The series of events in which a humidity stimulus is received and converted into a molecular signal." [GOC:dos]
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0098514
name: detection of high humidity stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity." [GOC:dos, PMID:18269908]
is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception
is_a: GO:0098516 ! detection of high humidity
relationship: part_of GO:0098510 ! sensory perception of high humidity

[Term]
id: GO:0098515
name: detection of low humidity stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity." [GOC:dos, PMID:18269908]
is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception
is_a: GO:0098517 ! detection of low humidity
relationship: part_of GO:0098511 ! sensory perception of low humidity

[Term]
id: GO:0098516
name: detection of high humidity
namespace: biological_process
def: "The series of events in which high humidity is detected and converted into a molecular signal." [GOC:dos]
is_a: GO:0098513 ! detection of humidity

[Term]
id: GO:0098517
name: detection of low humidity
namespace: biological_process
def: "The series of events in which low humidity is detected and converted into a molecular signal." [GOC:dos]
is_a: GO:0098513 ! detection of humidity

[Term]
id: GO:0098518
name: obsolete polynucleotide phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
consider: GO:0046403
consider: GO:0140818

[Term]
id: GO:0098519
name: obsolete nucleotide phosphatase activity, acting on free nucleotides
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate." [GOC:dos]
comment: This term was obsoleted because it represented an unnecessary grouping class.
synonym: "nucleotide phosphatase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0098520
name: excitatory neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction." [GOC:dos]
is_a: GO:0031594 ! neuromuscular junction
is_a: GO:0060076 ! excitatory synapse

[Term]
id: GO:0098521
name: inhibitory neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction." [GOC:dos]
comment: Inhibitory neuromuscular junctions are found in arthropods but not in vertebrates.
is_a: GO:0031594 ! neuromuscular junction
is_a: GO:0060077 ! inhibitory synapse

[Term]
id: GO:0098522
name: neuromuscular junction of skeletal muscle fiber
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber." [GOC:dos]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
is_a: GO:0098520 ! excitatory neuromuscular junction
is_a: GO:0098523 ! neuromuscular junction of myotube
is_a: GO:0098981 ! cholinergic synapse

[Term]
id: GO:0098523
name: neuromuscular junction of myotube
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes.
is_a: GO:0031594 ! neuromuscular junction

[Term]
id: GO:0098524
name: neuromuscular junction of somatic muscle myotube
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell." [GOC:dos]
is_a: GO:0098523 ! neuromuscular junction of myotube
is_a: GO:0098527 ! neuromuscular junction of somatic muscle

[Term]
id: GO:0098525
name: excitatory neuromuscular junction of somatic myotube
namespace: cellular_component
def: "A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells." [GOC:dos]
is_a: GO:0098520 ! excitatory neuromuscular junction
is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube

[Term]
id: GO:0098526
name: inhibitory neuromuscular junction of somatic myotube
namespace: cellular_component
def: "A neuromuscular junction that functions in the inhibition of somatic muscle myotube contraction. Examples of somatic muscle myotubes include the somatic muscle cells of arthropods." [GOC:dos]
is_a: GO:0098521 ! inhibitory neuromuscular junction
is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube

[Term]
id: GO:0098527
name: neuromuscular junction of somatic muscle
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods." [GOC:dos]
is_a: GO:0031594 ! neuromuscular junction

[Term]
id: GO:0098528
name: skeletal muscle fiber differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos]
is_a: GO:0014902 ! myotube differentiation
is_a: GO:0035914 ! skeletal muscle cell differentiation

[Term]
id: GO:0098529
name: neuromuscular junction development, skeletal muscle fiber
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber." [GOC:mtg_OBO2OWL_2013]
is_a: GO:0007528 ! neuromuscular junction development
relationship: part_of GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0098530
name: positive regulation of strand invasion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dos, GOC:dph, GOC:elh, GOC:tb]
synonym: "positive regulation of D-loop biosynthesis" RELATED [GOC:elh]
synonym: "positive regulation of D-loop formation" RELATED [GOC:elh]
synonym: "positive regulation of Rad51-mediated strand invasion" EXACT [GOC:elh]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0060542 ! regulation of strand invasion
relationship: positively_regulates GO:0042148 ! DNA strand invasion

[Term]
id: GO:0098531
name: ligand-modulated transcription factor activity
namespace: molecular_function
def: "A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors." [GOC:dos, PMID:25568920, PMID:8735275]
comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
synonym: "direct ligand regulated sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "ligand-activated transcription factor activity" NARROW []
synonym: "transcription factor activity, direct ligand regulated sequence-specific DNA binding" EXACT []
is_a: GO:0003700 ! DNA-binding transcription factor activity

[Term]
id: GO:0098532
name: obsolete histone H3-K27 trimethylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone." [PMID:19270745]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0098533
name: ATPase dependent transmembrane transport complex
namespace: cellular_component
def: "A transmembrane protein complex that functions in ATPase dependent active transport across a membrane." [GOC:dos]
comment: The location of this complex is implicit in its activity, so its location is asserted as a regular relationship rather than as a part of an intersection.
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:0098534
name: centriole assembly
namespace: biological_process
def: "A cellular process that results in the assembly of one or more centrioles." [GOC:dos, PMID:24075808]
is_a: GO:0031023 ! microtubule organizing center organization
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:0098535
name: de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
namespace: biological_process
def: "Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]
comment: In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
synonym: "centriole amplification" RELATED [PMID:24075808]
synonym: "de novo centriole assembly" BROAD []
synonym: "de novo centriole assembly via deuterosome" EXACT []
synonym: "deuterosomal basal body biogenesis" RELATED []
synonym: "deuterosome pathway" RELATED [PMID:25047614]
synonym: "deuterosome-mediated centriole biogenesis" RELATED [PMID:24075808]
synonym: "multiciliation" RELATED []
synonym: "multiciliogenesis" RELATED []
is_a: GO:0097742 ! de novo centriole assembly
relationship: part_of GO:1903251 ! multi-ciliated epithelial cell differentiation

[Term]
id: GO:0098536
name: deuterosome
namespace: cellular_component
def: "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles." [GOC:cilia, GOC:dos, PMID:24075808, PMID:25047614, PMID:5661997]
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0098537
name: obsolete lobed nucleus
namespace: cellular_component
def: "OBSOLETE. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans." [GOC:dos, GOC:tfm]
comment: This term was obsoleted because it does not correspond to a specific type of nucleus, it is a morphologically different nucleus present in certain cell types.
is_obsolete: true

[Term]
id: GO:0098538
name: lumenal side of transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the transport vesicle membrane that faces the lumen." [GOC:ab]
synonym: "internal side of transport vesicle membrane" EXACT []
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0030658 ! transport vesicle membrane

[Term]
id: GO:0098539
name: cytoplasmic side of transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the transport vesicle membrane that faces the cytoplasm." [GOC:ab]
synonym: "external side of transport vesicle membrane" EXACT []
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0030658 ! transport vesicle membrane

[Term]
id: GO:0098540
name: lumenal side of trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen." [GOC:ab]
synonym: "internal side of trans-Golgi network transport vesicle membrane" RELATED []
is_a: GO:0098538 ! lumenal side of transport vesicle membrane
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane

[Term]
id: GO:0098541
name: cytoplasmic side of trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the cytoplasm." [GOC:ab]
synonym: "external side of trans-Golgi network transport vesicle membrane" EXACT []
is_a: GO:0098539 ! cytoplasmic side of transport vesicle membrane
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane

[Term]
id: GO:0098542
name: defense response to other organism
namespace: biological_process
alt_id: GO:0009814
def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "defence response incompatible interaction" NARROW []
synonym: "defence response to pathogen, incompatible interaction" NARROW []
synonym: "defense response, incompatible interaction" NARROW []
synonym: "resistance response to pathogen" NARROW []
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0098543
name: detection of other organism
namespace: biological_process
alt_id: GO:0051824
def: "The series of events in which a stimulus from another organism is received and converted into a molecular signal." [GOC:dos]
synonym: "recognition of other organism during symbiotic interaction" NARROW [GOC:dph]
synonym: "recognition of other organism involved in symbiotic interaction" NARROW []
is_a: GO:0051707 ! response to other organism
is_a: GO:0098581 ! detection of external biotic stimulus

[Term]
id: GO:0098544
name: maintenance of protein complex location
namespace: biological_process
def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0051235 ! maintenance of location

[Term]
id: GO:0098545
name: maintenance of protein complex location in cytoplasm
namespace: biological_process
def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos]
is_a: GO:0051651 ! maintenance of location in cell
is_a: GO:0098544 ! maintenance of protein complex location

[Term]
id: GO:0098547
name: lumenal side of Golgi membrane
namespace: cellular_component
def: "The side of the Golgi membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0098548
name: cytoplasmic side of Golgi membrane
namespace: cellular_component
def: "The side (leaflet) of the Golgi membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0098549
name: somatic ring canal
namespace: cellular_component
def: "A stable intercellular bridge between somatic cells. Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects." [GOC:dos, PMID:22135360, PMID:670316]
is_a: GO:0045171 ! intercellular bridge

[Term]
id: GO:0098550
name: lumenal side of early endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the early endosome membrane that faces the lumen." [GOC:lr]
synonym: "internal leaflet of early endosome membrane" EXACT [GOC:ab]
synonym: "internal side of early endosome membrane" EXACT []
is_a: GO:0098565 ! lumenal side of endosome membrane
relationship: part_of GO:0031901 ! early endosome membrane

[Term]
id: GO:0098551
name: lumenal side of late endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the late endosome membrane that faces the lumen." [GOC:lr]
synonym: "internal leaflet of late endosome membrane" EXACT [GOC:ab]
synonym: "internal side of late endosome membrane" EXACT []
is_a: GO:0098565 ! lumenal side of endosome membrane
relationship: part_of GO:0031902 ! late endosome membrane

[Term]
id: GO:0098552
name: side of membrane
namespace: cellular_component
def: "A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface." [GOC:dos]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0098553
name: lumenal side of endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the plasma membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0098554
name: cytoplasmic side of endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0098555
name: lumenal side of rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0098556
name: cytoplasmic side of rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0098557
name: cytoplasmic side of smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane
relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane

[Term]
id: GO:0098558
name: lumenal side of smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane
relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane

[Term]
id: GO:0098559
name: cytoplasmic side of early endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the early endosome membrane that faces the cytoplasm." [GOC:lr]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
synonym: "external leaflet of early endosome membrane" EXACT [GOC:ab]
synonym: "external side of early endosome membrane" EXACT []
is_a: GO:0010009 ! cytoplasmic side of endosome membrane
relationship: part_of GO:0031901 ! early endosome membrane

[Term]
id: GO:0098560
name: cytoplasmic side of late endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the late endosome membrane that faces the cytoplasm." [GOC:lr]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
synonym: "external leaflet of late endosome membrane" EXACT [GOC:ab]
synonym: "external side of late endosome membrane" EXACT []
is_a: GO:0010009 ! cytoplasmic side of endosome membrane
relationship: part_of GO:0031902 ! late endosome membrane

[Term]
id: GO:0098561
name: methyl accepting chemotaxis protein complex
namespace: cellular_component
def: "A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus." [GOC:dos, PMID:1326408, PMID:15802240]
comment: A number of complexes of this class are found in E.coli.
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0098562
name: cytoplasmic side of membrane
namespace: cellular_component
def: "The side of a membrane that faces the cytoplasm." [GOC:dos]
is_a: GO:0098552 ! side of membrane

[Term]
id: GO:0098563
name: obsolete intrinsic component of synaptic vesicle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0030672

[Term]
id: GO:0098564
name: trans-Golgi network transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed within the membrane of a trans-Golgi network transport vesicle." [GOC:dos]
is_a: GO:0005796 ! Golgi lumen
is_a: GO:0098566 ! transport vesicle lumen
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0098565
name: lumenal side of endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the endosome membrane that faces the lumen." [GOC:dos]
synonym: "internal leaflet of endosome membrane" EXACT [GOC:ab]
synonym: "internal side of endosome membrane" EXACT []
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0098566
name: transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed within the membrane of a transport vesicle." [GOC:dos]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0030133 ! transport vesicle

[Term]
id: GO:0098567
name: periplasmic side of plasma membrane
namespace: cellular_component
def: "The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface." [GOC:dos]
is_a: GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0098568
name: external side of mycolate outer membrane
namespace: cellular_component
def: "The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface." [GOC:dos, PMID:18316738, PMID:18567661]
is_a: GO:0031240 ! external side of cell outer membrane

[Term]
id: GO:0098569
name: internal side of mycolate outer membrane
namespace: cellular_component
def: "The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network." [GOC:dos, PMID:18316738, PMID:18567661]
is_a: GO:0098552 ! side of membrane

[Term]
id: GO:0098570
name: stromal side of plastid inner membrane
namespace: cellular_component
def: "The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos]
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0098571
name: lumenal side of plastid thylakoid membrane
namespace: cellular_component
def: "The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface." [GOC:dos]
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0055035 ! plastid thylakoid membrane

[Term]
id: GO:0098572
name: stromal side of plastid thylakoid membrane
namespace: cellular_component
def: "The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos]
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0055035 ! plastid thylakoid membrane

[Term]
id: GO:0098573
name: obsolete intrinsic component of mitochondrial membrane
namespace: cellular_component
def: "OBSOLETE. The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to mitochondrial membrane" NARROW []
is_obsolete: true
replaced_by: GO:0031966

[Term]
id: GO:0098574
name: cytoplasmic side of lysosomal membrane
namespace: cellular_component
def: "The side (leaflet) of the lysosomal membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
synonym: "external leaflet of lysosomal membrane" EXACT [GOC:dos]
synonym: "external side of lysosomal membrane" EXACT []
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0098575
name: lumenal side of lysosomal membrane
namespace: cellular_component
def: "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos]
synonym: "internal leaflet of lysosomal membrane" EXACT [GOC:ab]
synonym: "internal side of lysosomal membrane" EXACT []
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0098576
name: lumenal side of membrane
namespace: cellular_component
def: "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos]
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0098577
name: inactive sex chromosome
namespace: cellular_component
def: "A sex chromosome that has been inactivated." [GOC:dos]
synonym: "inactivated sex chromosome" EXACT []
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0098578
name: condensed chromatin of inactivated sex chromosome
namespace: cellular_component
def: "A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation." [GOC:dos]
is_a: GO:0001739 ! sex chromatin
relationship: part_of GO:0098577 ! inactive sex chromosome

[Term]
id: GO:0098579
name: active sex chromosome
namespace: cellular_component
def: "A sex chromosome that has not been inactivated." [GOC:dos]
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0098580
name: obsolete chromatin of active sex chromosome
namespace: cellular_component
def: "OBSOLETE. Chromatin that is part of an active sex chromosome." [GOC:dos, PMID:23816838]
comment: This term was obsoleted because it represents a biological process, not a cellular localization.
is_obsolete: true

[Term]
id: GO:0098581
name: detection of external biotic stimulus
namespace: biological_process
def: "The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated." [GOC:dos]
synonym: "detection of exogenous biotic stimulus" EXACT []
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0043207 ! response to external biotic stimulus

[Term]
id: GO:0098582
name: innate vocalization behavior
namespace: biological_process
def: "A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur." [GOC:BHF, GOC:dos, GOC:rl]
is_a: GO:0071625 ! vocalization behavior

[Term]
id: GO:0098583
name: learned vocalization behavior
namespace: biological_process
def: "A vocalization behavior that is the result of learning." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]
comment: Examples include human speech and learned bird song.
is_a: GO:0071625 ! vocalization behavior
is_a: GO:0098598 ! learned vocalization behavior or vocal learning

[Term]
id: GO:0098584
name: host cell synaptic vesicle
namespace: cellular_component
def: "A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [GOC:dos]
is_a: GO:0044161 ! host cell cytoplasmic vesicle
relationship: part_of GO:0044221 ! host cell synapse

[Term]
id: GO:0098585
name: host cell synaptic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host synaptic vesicle." [GOC:dos]
is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane
relationship: part_of GO:0098584 ! host cell synaptic vesicle

[Term]
id: GO:0098586
name: cellular response to virus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:dos]
is_a: GO:0009615 ! response to virus

[Term]
id: GO:0098588
name: bounding membrane of organelle
namespace: cellular_component
def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]
comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes.
is_a: GO:0031090 ! organelle membrane

[Term]
id: GO:0098590
name: plasma membrane region
namespace: cellular_component
def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.
subset: gocheck_do_not_annotate
synonym: "region of plasma membrane" EXACT []
is_a: GO:0016020 ! membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0098591
name: external side of apical plasma membrane
namespace: cellular_component
def: "The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:ab, GOC:dos]
is_a: GO:0009897 ! external side of plasma membrane
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0098592
name: cytoplasmic side of apical plasma membrane
namespace: cellular_component
def: "The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0098593
name: goblet cell theca
namespace: cellular_component
def: "A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium. It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel." [PMID:6541604]
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0098594
name: mucin granule
namespace: cellular_component
def: "A secretory granule that contains mucin." [PMID:16377632]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0098595
name: perivitelline space
namespace: cellular_component
def: "The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane)." [GOC:dos]
is_a: GO:0005576 ! extracellular region

[Term]
id: GO:0098596
name: imitative learning
namespace: biological_process
def: "Learning in which new behaviors are acquired through imitation." [GOC:dos, Wikipedia:Imitative_learning&oldid=593192364]
xref: Wikipedia:Imitative_learning
xref: Wikipedia:Observational_learning#Observational_learning_compared_to_imitation
is_a: GO:0098597 ! observational learning

[Term]
id: GO:0098597
name: observational learning
namespace: biological_process
def: "Learning that occurs through observing the behavior of others." [GOC:dos, Wikipedia:Observational_learning&oldid=603524137]
comment: Observation here is used in a broad sense to include perception of the behavior of others via any form or combination of forms of sensory perception (visual, auditory etc). Observational learning is broader than imitative learning in that it does not require a duplication of the behavior exhibited by the model.
xref: Wikipedia:Observational_learning
is_a: GO:0007612 ! learning

[Term]
id: GO:0098598
name: learned vocalization behavior or vocal learning
namespace: biological_process
def: "Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]
comment: This grouping term is necessary because, in the absence of conditional mutations, it is not possible to use phenotypic evidence to distinguish an effect on vocal learning from an effect on learned vocalisation behavior.
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0098599
name: palmitoyl hydrolase activity
namespace: molecular_function
def: "Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate." [GOC:dos, GOC:pg]
xref: Reactome:R-HSA-5690046 "PPT2 hydrolyses PALMCoA to PALM"
xref: Reactome:R-HSA-9027670 "ESTG binding induces ESR depalmitoylation"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0098600
name: selenomethionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid." [PMID:11578145, PMID:16037612, PMID:16444005]
xref: Reactome:R-HSA-2408537 "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH"
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0098601
name: selenomethionine adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine." [PMID:2339986]
xref: Reactome:R-HSA-2408551 "SeMet is converted to AdoSeMet by MAT"
xref: RHEA:31211
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0098603
name: selenol Se-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine." [PMID:1711890]
xref: Reactome:R-HSA-2408544 "AdoSeMet is converted to AdeSeHCys by MetTrans(1)"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098604
name: adenosylselenohomocysteinase activity
namespace: molecular_function
def: "Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine." [GOC:dos, PMID:1711890, PMID:7305945]
xref: Reactome:R-HSA-2408532 "AdeSeHCys is hydrolysed to SeHCys by AHCY"
is_a: GO:0016802 ! trialkylsulfonium hydrolase activity

[Term]
id: GO:0098605
name: selenocystathionine beta-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O." [PMID:6456763]
xref: Reactome:R-HSA-2408559 "SeHCys and Ser are dehydrated into SeCysta by CBS"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0098606
name: selenocystathionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid." [PMID:6456763]
xref: Reactome:R-HSA-2408543 "SeCysta is hydrolysed to Sec by PXLP-K212-CTH"
xref: RHEA:31151
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0098607
name: methylselenocysteine deselenhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol." [PMID:17451884, PMID:20383543]
xref: Reactome:R-HSA-2408539 "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH"
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0098608
name: methylselenol demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH." [PMID:17451884, PMID:17988700]
xref: Reactome:R-HSA-2408530 "MeSeH is hydrolysed to H2Se by methylselenol demethylase"
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0098609
name: cell-cell adhesion
namespace: biological_process
alt_id: GO:0016337
def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos]
synonym: "single organismal cell-cell adhesion" RELATED []
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0098610
name: adhesion between unicellular organisms
namespace: biological_process
alt_id: GO:0098741
def: "The attachment of two unicellular organisms to each other." [GOC:dos]
synonym: "adhesion between unicellular organisms via cell-wall interaction" NARROW []
synonym: "multi-organismal cell-cell adhesion" BROAD []
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0098613
name: methaneselenol methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide." [PMID:14705, PMID:17988700, PMID:4380351]
xref: Reactome:R-HSA-2408541 "MeSeH is methylated to Me2Se by MeSeH methyltransferase"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098614
name: hydrogen selenide methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol." [PMID:14705, PMID:17988700]
xref: Reactome:R-HSA-2408536 "H2Se is methylated to MeSeH by H2Se methyltransferase"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098615
name: dimethyl selenide methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium." [PMID:17988700, PMID:3350800]
xref: Reactome:R-HSA-2408554 "Me2Se is methylated to Me3Se+ by INMT"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098616
name: selenate adenylyltransferase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate." [PMID:2537056]
xref: Reactome:R-HSA-2408525 "H2SeO4 is converted to APSe by PAPSS1,2"
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0098617
name: adenylylselenate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate." [PMID:2537056]
xref: Reactome:R-HSA-2408540 "APSe is phosphorylated to PAPSe by PAPSS1,2"
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0098618
name: selenomethionine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met)." [PMID:16661668, PMID:16661782]
xref: Reactome:R-HSA-2408546 "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0098619
name: selenocysteine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate." [PMID:8890909, PMID:9431993, PMID:9637248]
xref: Reactome:R-HSA-2408526 "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0098620
name: seryl-selenocysteinyl-tRNA kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP." [PMID:15317934]
xref: Reactome:R-HSA-2408507 "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK"
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0098621
name: O-phosphoseryl-tRNA(Sec) selenium transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid." [PMID:17142313, PMID:19608919, RHEA:25041]
synonym: "O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase" EXACT [EC:2.9.1.2]
synonym: "O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase" EXACT [] {comment="EC:2.9.1.2"}
synonym: "phosphoseryl-selenocysteinyl-tRNA selenium transferase activity" EXACT []
synonym: "SepSecS" EXACT []
xref: EC:2.9.1.2
xref: Reactome:R-HSA-2408555 "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer"
xref: RHEA:25041
is_a: GO:0016785 ! selenotransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0098622
name: selenodiglutathione-disulfide reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+." [PMID:1569062]
synonym: "selenodiglutathione-disulfide reductase (NADP) activity" EXACT []
synonym: "selenodiglutathione-disulfide reductase activity" BROAD []
xref: Reactome:R-HSA-2408542 "GSSeSG is reduced to GSSeH and GSH by GSR"
xref: RHEA:34927
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0098623
name: selenite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O." [PMID:1321713]
xref: Reactome:R-HSA-2408558 "SeO3(2-) is reduced to H2Se by TXNRD1"
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098624
name: 3'-phosphoadenylylselenate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+." [PMID:14723223]
synonym: "PAPSe reductase activity" EXACT [PMID:14723223]
xref: Reactome:R-HSA-2408548 "PAPSe is reduced to SeO3(2-) by PAPSe reductase"
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098625
name: methylselenol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O." [PMID:11782468]
xref: Reactome:R-HSA-5263614 "MeSeOH is reduced to MeSeH by TXNRD1"
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098626
name: methylseleninic acid reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O." [PMID:11782468]
xref: Reactome:R-HSA-5263616 "MeSeO2H is reduced to MeSeOH by TXNRD1"
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098627
name: protein arginine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phospho-L-arginyl-[protein] +H2O = L-arginyl-[protein] + phosphate." [PMID:23770242, RHEA:43380]
xref: EC:3.9.1.2
xref: RHEA:43380
is_a: GO:0004721 ! phosphoprotein phosphatase activity
is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds

[Term]
id: GO:0098628
name: peptidyl-N-phospho-arginine dephosphorylation
namespace: biological_process
def: "The removal of phosphate residues from peptidyl-N-phospho-arginine to form peptidyl-arginine." [PMID:23770242]
subset: gocheck_obsoletion_candidate
is_a: GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0098629
name: trans-Golgi network membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane." [GOC:di, GOC:dos, PMID:23345439]
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0098630
name: aggregation of unicellular organisms
namespace: biological_process
def: "The clustering together of unicellular organisms in suspension form aggregates." [GOC:dos]
synonym: "aggregation of single cell organisms" EXACT []
is_a: GO:0098743 ! cell aggregation

[Term]
id: GO:0098631
name: cell adhesion mediator activity
namespace: molecular_function
def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "cell adhesion molecule" EXACT []
synonym: "protein binding involved in cell adhesion" EXACT []
is_a: GO:0050839 ! cell adhesion molecule binding

[Term]
id: GO:0098632
name: cell-cell adhesion mediator activity
namespace: molecular_function
def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]
synonym: "cell-cell adhesion molecule" EXACT []
synonym: "protein binding involved in cell-cell adhesion" EXACT []
is_a: GO:0098631 ! cell adhesion mediator activity

[Term]
id: GO:0098633
name: collagen fibril binding
namespace: molecular_function
def: "Binding to a collagen fibril." [GOC:dos, PMID:21421911]
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0098634
name: cell-matrix adhesion mediator activity
namespace: molecular_function
def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix." [Wikipedia:Cell_adhesion]
synonym: "cell-matrix adhesion molecule" EXACT []
synonym: "protein binding involved in cell-matrix adhesion" EXACT []
is_a: GO:0098631 ! cell adhesion mediator activity

[Term]
id: GO:0098635
name: protein complex involved in cell-cell adhesion
namespace: cellular_component
def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos]
is_a: GO:0098636 ! protein complex involved in cell adhesion

[Term]
id: GO:0098636
name: protein complex involved in cell adhesion
namespace: cellular_component
alt_id: GO:1990307
def: "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell." [GOC:dos]
synonym: "cell adhesion complex" RELATED []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0098637
name: protein complex involved in cell-matrix adhesion
namespace: cellular_component
def: "Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion." [GOC:dos]
is_a: GO:0098636 ! protein complex involved in cell adhesion

[Term]
id: GO:0098638
name: laminin binding involved in cell-matrix adhesion
namespace: molecular_function
def: "Any laminin protein binding that occurs as part of cell-matrix adhesion." [GOC:dos]
is_a: GO:0043236 ! laminin binding
is_a: GO:0098634 ! cell-matrix adhesion mediator activity

[Term]
id: GO:0098639
name: collagen binding involved in cell-matrix adhesion
namespace: molecular_function
def: "Any collagen binding that occurs as part of cell-matrix adhesion." [GOC:dos]
is_a: GO:0005518 ! collagen binding
is_a: GO:0098634 ! cell-matrix adhesion mediator activity

[Term]
id: GO:0098640
name: integrin binding involved in cell-matrix adhesion
namespace: molecular_function
def: "Any integrin binding that occurs as part of the process of cell-matrix adhesion." [GOC:dos]
is_a: GO:0005178 ! integrin binding
is_a: GO:0098634 ! cell-matrix adhesion mediator activity

[Term]
id: GO:0098641
name: cadherin binding involved in cell-cell adhesion
namespace: molecular_function
def: "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos]
is_a: GO:0045296 ! cadherin binding
is_a: GO:0098632 ! cell-cell adhesion mediator activity

[Term]
id: GO:0098642
name: network-forming collagen trimer
namespace: cellular_component
def: "A collagen trimer that forms networks." [PMID:21421911]
is_a: GO:0005581 ! collagen trimer
relationship: part_of GO:0098645 ! collagen network

[Term]
id: GO:0098643
name: banded collagen fibril
namespace: cellular_component
def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:21421911]
is_a: GO:0098644 ! complex of collagen trimers
is_a: GO:0099512 ! supramolecular fiber

[Term]
id: GO:0098644
name: complex of collagen trimers
namespace: cellular_component
def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos]
synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541]
synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911]
is_a: GO:0099080 ! supramolecular complex
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0098645
name: collagen network
namespace: cellular_component
def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911]
is_a: GO:0098644 ! complex of collagen trimers
is_a: GO:0099081 ! supramolecular polymer

[Term]
id: GO:0098646
name: collagen sheet
namespace: cellular_component
def: "A protein complex that consists of collagen triple helices associated to form a sheet-like network." [GOC:dos, PMID:21421911]
synonym: "collagen hexagonal network" EXACT [PMID:21421911]
is_a: GO:0098645 ! collagen network

[Term]
id: GO:0098647
name: collagen beaded filament
namespace: cellular_component
def: "A supramolecular assembly of collagen trimers with a 'beads on a string'-like structure." [GOC:dos, PMID:19693541]
synonym: "beads on a string" RELATED [PMID:19693541]
is_a: GO:0099512 ! supramolecular fiber

[Term]
id: GO:0098648
name: collagen anchoring fibril
namespace: cellular_component
def: "A specialised collagen fibril that functions as an anchor, binding to other collagen structures." [GOC:dos]
is_a: GO:0098644 ! complex of collagen trimers

[Term]
id: GO:0098649
name: obsolete response to peptidyl-dipeptidase A inhibitor
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos]
comment: This term was obsoleted because it does not represent a physiological process.
synonym: "response to ACE inhibitor" NARROW []
synonym: "response to angiotensin-converting enzyme inhibitor" NARROW []
is_obsolete: true

[Term]
id: GO:0098650
name: peptidyl-proline 4-dioxygenase binding
namespace: molecular_function
def: "Binding to a peptidyl-proline 4-dioxygenase." [GOC:dos, GOC:kvm]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0098651
name: basement membrane collagen trimer
namespace: cellular_component
def: "Any collagen timer that is part of a basement membrane." [GOC:dos, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0098652
name: collagen type VII anchoring fibril
namespace: cellular_component
def: "An antiparallel dimer of two collagen VII trimers, one end of which is embedded in the lamina densa while the other end attaches to banded collagen fibrils in the dermis." [PMID:19693541]
is_a: GO:0098648 ! collagen anchoring fibril

[Term]
id: GO:0098653
name: centromere clustering
namespace: biological_process
alt_id: GO:0098587
def: "The process by which centromeres/kinetochores become localized to clusters." [GOC:di, GOC:dos, PMID:10761928, PMID:23283988, PMID:8486732]
comment: As inner kinetochores are an integral part of centromeres, we treat centromere and kinetochore clustering as the same process.
synonym: "kinetochore clustering" EXACT []
is_a: GO:0050000 ! chromosome localization
is_a: GO:0072765 ! centromere localization

[Term]
id: GO:0098654
name: CENP-A recruiting complex
namespace: cellular_component
def: "A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere." [PMID:24774534]
synonym: "MIS18 complex" NARROW [GOC:bhm, GOC:vw]
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:0098655
name: monoatomic cation transmembrane transport
namespace: biological_process
alt_id: GO:0099132
def: "The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]
synonym: "ATP hydrolysis coupled cation transmembrane transport" NARROW []
synonym: "cation transmembrane transport" BROAD []
is_a: GO:0006812 ! monoatomic cation transport
is_a: GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0098656
name: monoatomic anion transmembrane transport
namespace: biological_process
alt_id: GO:0099133
def: "The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]
synonym: "anion transmembrane transport" EXACT []
synonym: "ATP hydrolysis coupled anion transmembrane transport" NARROW []
is_a: GO:0006820 ! monoatomic anion transport
is_a: GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0098657
name: import into cell
namespace: biological_process
def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0006810 ! transport

[Term]
id: GO:0098658
name: inorganic anion import across plasma membrane
namespace: biological_process
def: "The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "inorganic anion import into cell" EXACT []
is_a: GO:0098661 ! inorganic anion transmembrane transport
is_a: GO:0099587 ! inorganic ion import across plasma membrane

[Term]
id: GO:0098659
name: inorganic cation import across plasma membrane
namespace: biological_process
def: "The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "inorganic cation import into cell" EXACT []
is_a: GO:0098662 ! inorganic cation transmembrane transport
is_a: GO:0099587 ! inorganic ion import across plasma membrane

[Term]
id: GO:0098660
name: inorganic ion transmembrane transport
namespace: biological_process
def: "The process in which an inorganic ion is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "inorganic ion membrane transport" EXACT []
synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0098661
name: inorganic anion transmembrane transport
namespace: biological_process
def: "The process in which an inorganic anion is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "inorganic anion membrane transport" EXACT []
synonym: "transmembrane inorganic anion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0098660 ! inorganic ion transmembrane transport

[Term]
id: GO:0098662
name: inorganic cation transmembrane transport
namespace: biological_process
alt_id: GO:0015672
alt_id: GO:0072511
def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "divalent inorganic cation transport" NARROW []
synonym: "inorganic cation membrane transport" EXACT []
synonym: "monovalent inorganic cation transport" NARROW []
synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0098660 ! inorganic ion transmembrane transport

[Term]
id: GO:0098663
name: obsolete transmembrane transporter activity involved in import into cell
namespace: molecular_function
def: "OBSOLETE. Any transmembrane transporter activity that is involved in importing some substance into a cell." [GOC:dos]
comment: The reason for obsoletion is that this terms partly represents the process "import into cell".
is_obsolete: true

[Term]
id: GO:0098664
name: G protein-coupled serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "G-protein coupled serotonin receptor signaling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0098665
name: serotonin receptor complex
namespace: cellular_component
def: "A protein complex that is capable of serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]
synonym: "5-HT receptor complex" EXACT []
synonym: "5-hydroxytryptamine receptor complex" EXACT []
synonym: "5HT receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0098666
name: G protein-coupled serotonin receptor complex
namespace: cellular_component
def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie]
synonym: "G-protein coupled serotonin receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0098669
name: superinfection exclusion
namespace: biological_process
def: "The process by which a preexisting viral infection prevents a secondary infection with the same or a closely related virus. Typically some aspect of viral entry is inhibited, but post entry mechanisms have also been documented." [PMID:11985726, PMID:23692331, PMID:24089557, PMID:8012757, VZ:3971]
xref: VZ:3971 "Superinfection exclusion"
is_a: GO:0016032 ! viral process

[Term]
id: GO:0098670
name: entry receptor-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that mediates/triggers viral entry by endocytosis/pinocytosis or by inducing fusion/penetration." [PMID:18351291, VZ:3942]
synonym: "viral attachment to host entry receptor" EXACT [VZ:3942]
xref: VZ:3942
is_a: GO:0046813 ! receptor-mediated virion attachment to host cell

[Term]
id: GO:0098671
name: adhesion receptor-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that does not mediate or trigger entry into the host cell. This binding is typically reversible and enhances significantly infectivity by concentrating the virus in the vicinity of its entry receptors, or bringing it to an organ in which its target cells are located." [PMID:18351291, VZ:3943]
synonym: "viral attachment to host adhesion receptor" EXACT [VZ:3943]
xref: VZ:3943
is_a: GO:0046813 ! receptor-mediated virion attachment to host cell

[Term]
id: GO:0098672
name: symbiont-mediated suppression of host CRISPR-cas system
namespace: biological_process
def: "A process by which a symbiont inhibits or disrupts the CRISPR-cas system of its host. Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves from infection by bacteriophages (phages), and phages have various mechanisms to counter the CRISPR-cas system." [PMID:23242138, PMID:23446421, PMID:26416740, PMID:28749735]
synonym: "anti-CRISPR" BROAD []
synonym: "CRISPR-cas system evasion by virus" EXACT [VZ:3962]
synonym: "evasion by virus of CRISPR-cas system" RELATED []
synonym: "inhibition of host CRISPR-cas system by virus" RELATED []
synonym: "suppression of host CRISPR-cas system" EXACT []
xref: VZ:3962
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response

[Term]
id: GO:0098673
name: symbiont-mediated suppression of host DNA replication
namespace: biological_process
def: "Any process by which a virus inhibits DNA replication in its host cell. Some bacteriophages are known to do this, possibly as a way of increasing the pool of nucleotides available for virus replication." [PMID:17010157, PMID:21205014]
synonym: "inhibition of host DNA replication by virus" NARROW []
xref: VZ:3948
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0098674
name: extrinsic component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098922 ! extrinsic component of dense core granule membrane
relationship: part_of GO:0099012 ! neuronal dense core vesicle membrane

[Term]
id: GO:0098675
name: obsolete intrinsic component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to neuronal dense core granule membrane" EXACT []
is_obsolete: true
replaced_by: GO:0099012

[Term]
id: GO:0098676
name: symbiont-mediated modulation of host virulence
namespace: biological_process
def: "A process by which a virus improves the virulence of its host for that host's respective host. Common in but not limited to bacteriophages; also occurs in phage-bearing bacteria infecting plants or animals for example. Mechanisms include the expression of factors that modulate a bacterial adhesion to a host cell, spread through host tissues, production of exotoxins or provide protection against host immune defenses." [PMID:10913072, PMID:11553559, PMID:22919604, PMID:8658163, VZ:3965]
synonym: "modulation of host virulence by virus" NARROW []
xref: VZ:3965 "Modulation of host virulence by virus"
is_a: GO:0044003 ! symbiont-mediated perturbation of host process

[Term]
id: GO:0098677
name: virion maturation
namespace: biological_process
def: "Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection." [ISBN:0781718325, VZ:1946]
synonym: "viral particle maturation" EXACT []
synonym: "virus particle maturation" RELATED []
xref: VZ:1946
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019075 ! virus maturation

[Term]
id: GO:0098678
name: viral tropism switching
namespace: biological_process
def: "A process by which the range of hosts which a virus can bind and infect is changed. Examples include phages that switch between types of fibers via the action of a virally encoded invertase." [PMID:6232613, VZ:4498]
xref: VZ:4498 "Viral receptor tropism switching"
is_a: GO:0016032 ! viral process

[Term]
id: GO:0098679
name: obsolete regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate catabloism." [PMID:16408318]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of carbohydrate catabolism by regulation of transcription from RNA polymerase II promoter" EXACT []
is_obsolete: true

[Term]
id: GO:0098680
name: template-free RNA nucleotidyltransferase
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template." [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:nc, PMID:15994230]
is_a: GO:0016779 ! nucleotidyltransferase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0098681
name: synaptic ribbon
namespace: cellular_component
def: "A non-membrane bound, electron dense structure associated that extends perpendicular to the presynaptic membrane in ribbon synapses. The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. Synaptic ribbons may be plate like or spherical." [PMID:15626493]
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0098682
name: arciform density
namespace: cellular_component
def: "An electron dense structure that anchors a synaptic ribbon to the presynaptic membrane." [PMID:15626493]
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0097470 ! ribbon synapse

[Term]
id: GO:0098683
name: cochlear hair cell ribbon synapse
namespace: cellular_component
def: "A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density." [PMID:15626493]
subset: goslim_synapse
is_a: GO:0097470 ! ribbon synapse

[Term]
id: GO:0098684
name: photoreceptor ribbon synapse
namespace: cellular_component
def: "A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon." [PMID:15626493]
subset: goslim_synapse
is_a: GO:0097470 ! ribbon synapse

[Term]
id: GO:0098685
name: Schaffer collateral - CA1 synapse
namespace: cellular_component
def: "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098686
name: hippocampal mossy fiber to CA3 synapse
namespace: cellular_component
def: "One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell." [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762]
subset: goslim_synapse
is_a: GO:0098984 ! neuron to neuron synapse

[Term]
id: GO:0098687
name: chromosomal region
namespace: cellular_component
def: "Any subdivision of a chromosome along its length." [GOC:dos]
comment: Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore.
synonym: "chromosome region" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0098688
name: parallel fiber to Purkinje cell synapse
namespace: cellular_component
def: "An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells." [PMID:16623829, PMID:3209740]
subset: goslim_synapse
is_a: GO:0060076 ! excitatory synapse

[Term]
id: GO:0098689
name: latency-replication decision
namespace: biological_process
def: "The process by which a virus switches on its replication cycle in an infected cell. The process is typically controlled by a genetic switch controlled by environmental factors such as cell type, cell shape, the availability of nutrients, superinfection or exposure of infected cells to UV or various chemical stimuli." [PMID:19416825, PMID:24339346, VZ:3964]
synonym: "Latency-replication switch" EXACT []
synonym: "lytic switch" EXACT []
synonym: "prophage induction" NARROW []
synonym: "proviral induction" EXACT []
synonym: "proviral switch" EXACT []
synonym: "reactivation of latent virus" EXACT []
xref: VZ:3964 "Latency-replication decision"
is_a: GO:0016032 ! viral process
relationship: regulates GO:0019046 ! release from viral latency

[Term]
id: GO:0098690
name: glycinergic synapse
namespace: cellular_component
def: "A synapse that uses glycine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098691
name: dopaminergic synapse
namespace: cellular_component
def: "A synapse that uses dopamine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098692
name: noradrenergic synapse
namespace: cellular_component
def: "A synapse that uses noradrenaline as a neurotransmitter." [GOC:dos]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098693
name: regulation of synaptic vesicle cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle." [GOC:dos]
subset: goslim_synapse
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0098694
name: regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane

[Term]
id: GO:0098695
name: inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos]
subset: goslim_synapse
synonym: "IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT []
is_a: GO:0005220 ! inositol 1,4,5-trisphosphate-gated calcium channel activity

[Term]
id: GO:0098696
name: regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:1902473 ! regulation of protein localization to synapse
is_a: GO:1902683 ! regulation of receptor localization to synapse
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:0099645 ! neurotransmitter receptor localization to postsynaptic specialization membrane

[Term]
id: GO:0098697
name: ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005219 ! ryanodine-sensitive calcium-release channel activity
is_a: GO:1905058 ! calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0098698
name: postsynaptic specialization assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0070925 ! organelle assembly
is_a: GO:0099084 ! postsynaptic specialization organization
relationship: part_of GO:0099068 ! postsynapse assembly

[Term]
id: GO:0098699
name: structural constituent of presynaptic actin cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005200 ! structural constituent of cytoskeleton
is_a: GO:0099181 ! structural constituent of presynapse

[Term]
id: GO:0098700
name: neurotransmitter loading into synaptic vesicle
namespace: biological_process
def: "The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps." [GOC:bf, GOC:pad, GOC:PARL, PMID:10099709, PMID:15217342]
subset: goslim_synapse
synonym: "neurotransmitter import into synaptic vesicle" EXACT []
synonym: "neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342]
synonym: "synaptic vesicle neurotransmitter loading" EXACT syngo_official_label []
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0098702
name: adenine import across plasma membrane
namespace: biological_process
alt_id: GO:0061488
def: "The directed movement of adenine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "adenine import into cell" EXACT []
is_a: GO:0015853 ! adenine transport
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1904823 ! purine nucleobase transmembrane transport

[Term]
id: GO:0098703
name: calcium ion import across plasma membrane
namespace: biological_process
alt_id: GO:1990035
def: "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "calcium ion import into cell" EXACT []
synonym: "calcium ion uptake into cell" EXACT [GOC:vw]
is_a: GO:0070509 ! calcium ion import
is_a: GO:0097553 ! calcium ion transmembrane import into cytosol
is_a: GO:0098659 ! inorganic cation import across plasma membrane
is_a: GO:1902656 ! calcium ion import into cytosol

[Term]
id: GO:0098704
name: carbohydrate import across plasma membrane
namespace: biological_process
alt_id: GO:0097319
def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "carbohydrate import into cell" EXACT []
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098705
name: copper ion import across plasma membrane
namespace: biological_process
alt_id: GO:0015678
alt_id: GO:1902861
def: "The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "copper cation import into cell" EXACT []
synonym: "copper ion import into cell" EXACT []
synonym: "high affinity copper ion transport" NARROW []
synonym: "high affinity copper transport" NARROW []
synonym: "high-affinity copper ion transport" NARROW []
is_a: GO:0015679 ! plasma membrane copper ion transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:0098706
name: iron ion import across cell outer membrane
namespace: biological_process
alt_id: GO:0015683
alt_id: GO:0097461
def: "The directed movement of iron ions from outside of a cell, across the cell outer membrane and into the periplasmic space." [GOC:mah, PMID:23192658]
synonym: "ferric ion import into cell" EXACT [GOC:mah]
synonym: "ferric iron import across cell outer membrane" NARROW []
synonym: "ferric iron import into cell" EXACT []
synonym: "ferric iron transmembrane transport" BROAD []
synonym: "high affinity ferric iron transport" NARROW []
synonym: "high-affinity ferric iron transmembrane transport" NARROW []
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0098708
name: D-glucose import across plasma membrane
namespace: biological_process
alt_id: GO:0061490
alt_id: GO:1990821
def: "The directed movement of D-glucose from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "glucose import across plasma membrane" EXACT []
synonym: "glucose import into cell" EXACT []
synonym: "high affinity glucose import" NARROW []
is_a: GO:0140271 ! hexose import across plasma membrane
is_a: GO:1904659 ! D-glucose transmembrane transport

[Term]
id: GO:0098709
name: glutathione import across plasma membrane
namespace: biological_process
alt_id: GO:0036347
def: "The directed movement of glutathione from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "glutathione import into cell" EXACT []
synonym: "glutathione uptake" EXACT [GOC:bf]
is_a: GO:0034775 ! glutathione transmembrane transport
is_a: GO:0140207 ! tripeptide import across plasma membrane

[Term]
id: GO:0098710
name: guanine import across plasma membrane
namespace: biological_process
alt_id: GO:0061489
def: "The directed movement of guanine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "guanine import into cell" EXACT []
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1903716 ! guanine transmembrane transport

[Term]
id: GO:0098711
name: iron ion import across plasma membrane
namespace: biological_process
alt_id: GO:0097459
alt_id: GO:0097460
alt_id: GO:0098707
def: "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:mah, PMID:8321236]
synonym: "ferrous ion import into cell" RELATED [GOC:mah]
synonym: "ferrous iron import across plasma membrane" RELATED []
synonym: "ferrous iron import into cell" RELATED []
synonym: "iron import into cell" RELATED [GOC:mah]
synonym: "iron ion import into cell" EXACT []
is_a: GO:0033212 ! iron import into cell
is_a: GO:0034755 ! iron ion transmembrane transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:0098712
name: L-glutamate import across plasma membrane
namespace: biological_process
alt_id: GO:1903802
alt_id: GO:1990123
def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "L-glutamate import into cell" EXACT []
synonym: "L-glutamate(1-) import across plasma membrane" BROAD []
synonym: "L-glutamate(1-) import into cell" EXACT []
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane

[Term]
id: GO:0098713
name: obsolete leucine import across plasma membrane
namespace: biological_process
alt_id: GO:1990122
def: "OBSOLETE. The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
comment: This term has been obsoleted because it represents the same process as GO:1903801 L-leucine import across plasma membrane.
synonym: "L-leucine import into cell" NARROW [GOC:mah]
synonym: "leucine import into cell" EXACT []
is_obsolete: true
replaced_by: GO:1903801

[Term]
id: GO:0098714
name: malate import across plasma membrane
namespace: biological_process
alt_id: GO:0097405
def: "The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "malate import into cell" EXACT []
is_a: GO:0071423 ! malate transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098715
name: malonic acid import across plasma membrane
namespace: biological_process
alt_id: GO:0097406
def: "The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "malonate import into cell" EXACT []
synonym: "malonic acid import into cell" EXACT []
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1901553 ! malonic acid transmembrane transport

[Term]
id: GO:0098716
name: nickel cation import across plasma membrane
namespace: biological_process
alt_id: GO:0090509
def: "The directed movement of nickel cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "nickel cation import into cell" EXACT []
is_a: GO:0035444 ! nickel cation transmembrane transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:0098717
name: pantothenate import across plasma membrane
namespace: biological_process
alt_id: GO:0044755
alt_id: GO:1901688
def: "The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "pantothenate import" RELATED []
synonym: "pantothenate import into cell" EXACT []
is_a: GO:0015887 ! pantothenate transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098718
name: serine import across plasma membrane
namespace: biological_process
alt_id: GO:0061491
def: "The directed movement of serine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "serine import into cell" EXACT []
is_a: GO:0032329 ! serine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0098719
name: sodium ion import across plasma membrane
namespace: biological_process
alt_id: GO:0097369
alt_id: GO:1990118
def: "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "sodium import" EXACT []
synonym: "sodium ion import" RELATED []
synonym: "sodium ion import into cell" EXACT []
is_a: GO:0035725 ! sodium ion transmembrane transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:0098720
name: succinate import across plasma membrane
namespace: biological_process
alt_id: GO:0097404
def: "The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "succinate import into cell" EXACT []
is_a: GO:0071422 ! succinate transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098721
name: uracil import across plasma membrane
namespace: biological_process
alt_id: GO:1902431
def: "The directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "uracil import into cell" EXACT []
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1903791 ! uracil transmembrane transport

[Term]
id: GO:0098722
name: asymmetric stem cell division
namespace: biological_process
def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950]
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0017145 ! stem cell division

[Term]
id: GO:0098723
name: skeletal muscle myofibril
namespace: cellular_component
def: "A myofibril of a skeletal muscle fiber." [GOC:dos]
is_a: GO:0030016 ! myofibril

[Term]
id: GO:0098724
name: symmetric stem cell division
namespace: biological_process
def: "Symmetric division of a stem cell to produce two stem cells of the same type as the parent. Symmetric stem cell division is necessary for amplification of stem cell populations in the absence of sources of stem cells external to an existing population." [PMID:19948499, PMID:23303905]
comment: Examples include the self-renewal of spermatogonial stem cells and (some) division during amplification of skeletal muscle satellite cell populations.
is_a: GO:0017145 ! stem cell division
is_a: GO:0098725 ! symmetric cell division

[Term]
id: GO:0098725
name: symmetric cell division
namespace: biological_process
def: "Cell division in which both daughter cells are of the same type." [GOC:dos]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0098726
name: symmetric division of skeletal muscle satellite stem cell
namespace: biological_process
def: "The symmetric division of a skeletal muscle satellite stem cell, resulting in two skeletal muscle satellite stem cells. This process is involved in amplification of the pool of these cells." [PMID:23303905]
is_a: GO:0048103 ! somatic stem cell division
is_a: GO:0098724 ! symmetric stem cell division

[Term]
id: GO:0098727
name: maintenance of cell number
namespace: biological_process
def: "Any process by which the numbers of cells of a particular type or in a tissue are maintained." [GOC:dos]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0098728
name: germline stem cell asymmetric division
namespace: biological_process
def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos]
is_a: GO:0042078 ! germ-line stem cell division
is_a: GO:0098722 ! asymmetric stem cell division

[Term]
id: GO:0098729
name: germline stem cell symmetric division
namespace: biological_process
def: "Division of a germline stem cell to produce two germline stem cells of the same type as the parent." [GOC:dos, PMID:19948499]
is_a: GO:0042078 ! germ-line stem cell division
is_a: GO:0098724 ! symmetric stem cell division

[Term]
id: GO:0098730
name: male germline stem cell symmetric division
namespace: biological_process
def: "The symmetric division of a male germline stem cell to produce two male germline stem cells. An example of this is found in mammalian spermatogonial stem cells, some proportion of which divide symmetrically, so amplifying the population. The choice between asymmetric and symmetric division in this case appears to be internal and stochastic." [GOC:dos, PMID:19948499]
is_a: GO:0098729 ! germline stem cell symmetric division

[Term]
id: GO:0098731
name: skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells." [PMID:23303905]
is_a: GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
is_a: GO:0035019 ! somatic stem cell population maintenance

[Term]
id: GO:0098732
name: macromolecule deacylation
namespace: biological_process
def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule." [GOC:dos]
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0098733
name: hemidesmosome associated protein complex
namespace: cellular_component
def: "Any protein complex that is part of or has some part in a hemidesmosome." [GOC:dos]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0098734
name: macromolecule depalmitoylation
namespace: biological_process
def: "The removal of palymitoyl groups from a macromolecule." [GOC:dos]
is_a: GO:0098732 ! macromolecule deacylation

[Term]
id: GO:0098735
name: positive regulation of the force of heart contraction
namespace: biological_process
def: "Any process that increases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280]
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0098736
name: negative regulation of the force of heart contraction
namespace: biological_process
def: "Any process that decreases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280]
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0098737
name: protein insertion into plasma membrane
namespace: biological_process
def: "The process that results in the incorporation of a protein into a plasma membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:DOS]
is_a: GO:0051205 ! protein insertion into membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0098739
name: import across plasma membrane
namespace: biological_process
def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0098657 ! import into cell

[Term]
id: GO:0098740
name: obsolete multi organism cell adhesion
namespace: biological_process
def: "OBSOLETE. Cell adhesion that involves cells from multiple organisms or that is mediated by gene products from multiple organisms." [GOC:dos]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0098742
name: cell-cell adhesion via plasma-membrane adhesion molecules
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0098743
name: cell aggregation
namespace: biological_process
def: "The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation." [GOC:dos]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0098744
name: 1-phosphatidylinositol 4-kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of 1-phosphatidylinositol 4-kinase." [PMID:21288895]
is_a: GO:0019209 ! kinase activator activity

[Term]
id: GO:0098745
name: RNA decapping complex
namespace: cellular_component
def: "A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA." [GOC:dos, GOC:vw, PMID:22323607]
comment: Additional components may be present, for example in ascomycetes this complex includes an additional regulatory subunit, Edc1.
synonym: "Dcp1-Dcp2 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0098746
name: fast, calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release." [GOC:dos, GOC:pad, GOC:PARL, PMID:4405553, PMID:7809151, PMID:7954835]
synonym: "synchronous, calcium ion-dependent exocytosis of neurotransmitter" EXACT [PMID:7954835]
is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter

[Term]
id: GO:0098747
name: slow, calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release." [GOC:dos, GOC:pad, GOC:parl, PMID:7809151, PMID:7954835]
is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter

[Term]
id: GO:0098749
name: cerebellar neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0098750
name: FYXD domain binding
namespace: molecular_function
def: "Binding to a FXYD domain." [GOC:dos, GOC:mr, PMID:10950925, PMID:16403837, PMID:18000745]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0098751
name: bone cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development.
subset: gocheck_do_not_annotate
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0098752
name: obsolete integral component of the cytoplasmic side of the plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0009898

[Term]
id: GO:0098753
name: obsolete anchored component of the cytoplasmic side of the plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0009898

[Term]
id: GO:0098754
name: detoxification
namespace: biological_process
def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos]
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0009636 ! response to toxic substance

[Term]
id: GO:0098755
name: maintenance of seed dormancy by absisic acid
namespace: biological_process
def: "The process by which seed dormancy is maintained by the presence of absisic acid." [GOC:dos, PMID:9580097]
is_a: GO:0010231 ! maintenance of seed dormancy
relationship: part_of GO:0009737 ! response to abscisic acid

[Term]
id: GO:0098756
name: response to interleukin-21
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-21" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0098757
name: cellular response to interleukin-21
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah]
synonym: "cellular response to IL-21" EXACT [GOC:mah]
is_a: GO:0098756 ! response to interleukin-21

[Term]
id: GO:0098758
name: response to interleukin-8
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-8" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0098759
name: cellular response to interleukin-8
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah]
synonym: "cellular response to IL-8" EXACT [GOC:mah]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0098758 ! response to interleukin-8

[Term]
id: GO:0098760
name: response to interleukin-7
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-7" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0098761
name: cellular response to interleukin-7
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah]
synonym: "cellular response to IL-7" EXACT [GOC:mah]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0098760 ! response to interleukin-7

[Term]
id: GO:0098762
name: meiotic cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0098763
name: mitotic cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0098764
name: meiosis I cell cycle phase
namespace: biological_process
def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0098765
name: meiosis II cell cycle phase
namespace: biological_process
def: "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division)." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0098766
name: obsolete meiosis I M phase
namespace: biological_process
def: "OBSOLETE. M phase during meiosis I." [GOC:dos]
comment: Obsoleted because added in error.
is_obsolete: true
consider: GO:0098762

[Term]
id: GO:0098767
name: obsolete meiosis II M phase
namespace: biological_process
def: "OBSOLETE. M phase during meiosis II." [GOC:dos]
comment: Obsoleted because added in error.
is_obsolete: true
consider: GO:0098762

[Term]
id: GO:0098768
name: meiotic prometaphase I
namespace: biological_process
def: "The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate." [PMID:16012859]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0051327 ! meiotic M phase

[Term]
id: GO:0098769
name: TIMP family protein binding
namespace: molecular_function
def: "Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family." [PMID:22078297]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0098770
name: FBXO family protein binding
namespace: molecular_function
def: "Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction." [PMID:11178263]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0098771
name: inorganic ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]
subset: goslim_pombe
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0098772
name: molecular function regulator activity
namespace: molecular_function
def: "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "molecular function regulator" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0098773
name: skin epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos]
is_a: GO:0008544 ! epidermis development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0098774
name: curli
namespace: cellular_component
def: "A proteinaceous extracellular fiber, produced by an enteric bacterium, that is involved in surface and cell-cell contacts that promote community behavior and host colonization." [PMID:16704339]
synonym: "tafi" NARROW [PMID:16704339]
synonym: "thin aggregative fimbrae" NARROW [PMID:16704339]
is_a: GO:0009289 ! pilus
relationship: part_of GO:0097311 ! bacterial biofilm matrix

[Term]
id: GO:0098775
name: curli assembly
namespace: biological_process
def: "The process of assembly of curli, extracellular fibers produced by enteric bacteria. This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex." [PMID:16704339]
is_a: GO:0009297 ! pilus assembly

[Term]
id: GO:0098776
name: protein transport across the cell outer membrane
namespace: biological_process
def: "The directed movement of proteins across the cell outer membrane." [GOC:dos]
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0098777
name: protein secretion by the type VIII secretion system
namespace: biological_process
def: "Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits." [PMID:19299134, PMID:24080089]
comment: This term is defined so as to leave open the possibility that things other than curli subunits are secreted via same secretory system as that used by curli subunits.
synonym: "T8SS" EXACT [PMID:19299134]
is_a: GO:0098776 ! protein transport across the cell outer membrane

[Term]
id: GO:0098778
name: curli subunit secretion coupled to curli assembly
namespace: biological_process
def: "The secretion of soluble curli subunits through the outer membrane, coupled to nucleation of curli fiber formation at the membrane surface." [PMID:24080089]
synonym: "extracellular nucleation-precipitation pathway" EXACT [PMID:19299134]
is_a: GO:0098777 ! protein secretion by the type VIII secretion system
relationship: part_of GO:0098775 ! curli assembly

[Term]
id: GO:0098779
name: obsolete positive regulation of mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GOC:PARL, PMID:18200046, PMID:23985961]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term.
is_obsolete: true
replaced_by: GO:1905091

[Term]
id: GO:0098780
name: response to mitochondrial depolarisation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria." [GOC:dos]
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0098781
name: obsolete ncRNA transcription
namespace: biological_process
def: "OBSOLETE. The transcription of non (protein) coding RNA from a DNA template." [GOC:dos]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0006351

[Term]
id: GO:0098782
name: mechanosensitive potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress." [PMID:22282805, PMID:25471887, PMID:25500157]
synonym: "mechanically-gated potassium channel activity" EXACT []
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0140135 ! mechanosensitive monoatomic cation channel activity

[Term]
id: GO:0098784
name: biofilm matrix organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix." [GOC:mah]
synonym: "biofilm matrix organization and biogenesis" RELATED [GOC:dos]
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0098785
name: biofilm matrix assembly
namespace: biological_process
def: "A process that results in the assembly of a biofilm matrix." [GOC:mah]
is_a: GO:0085029 ! extracellular matrix assembly
is_a: GO:0098784 ! biofilm matrix organization
relationship: part_of GO:0042710 ! biofilm formation

[Term]
id: GO:0098786
name: biofilm matrix disassembly
namespace: biological_process
def: "A process that results in the disassembly of a biofilm matrix." [GOC:mah]
is_a: GO:0022617 ! extracellular matrix disassembly
is_a: GO:0098784 ! biofilm matrix organization

[Term]
id: GO:0098787
name: obsolete mRNA cleavage involved in mRNA processing
namespace: biological_process
def: "OBSOLETE. Cleavage of an immature mRNA transcript to produce one or more more mature mRNA transcripts, prior to translation into polypeptide." [GOC:dos]
comment: This term was obsoleted because it represents a molecular function
is_obsolete: true

[Term]
id: GO:0098788
name: dendritic knob
namespace: cellular_component
def: "The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium." [PMID:20801626]
synonym: "apical dendritic knob" EXACT []
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0098789
name: obsolete pre-mRNA cleavage required for polyadenylation
namespace: biological_process
def: "OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]
synonym: "cleavage and polyadenylylation specificity factor activity" RELATED []
synonym: "pre-mRNA cleavage factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0098790
name: obsolete ncRNA transcription associated with protein coding gene TSS/TES
namespace: biological_process
def: "OBSOLETE. The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes." [PMID:20502517]
comment: The reason for obsoletion is that this term was added in error.
synonym: "pasRNA transcription" NARROW [PMID:20502517]
is_obsolete: true

[Term]
id: GO:0098791
name: Golgi apparatus subcompartment
namespace: cellular_component
def: "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus." [GOC:dos]
synonym: "Golgi subcompartment" EXACT []
is_a: GO:0031984 ! organelle subcompartment
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0098792
name: xenophagy
namespace: biological_process
def: "The selective degradation of intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) by macroautophagy." [GOC:autophagy, GOC:pad, GOC:PARL, PMID:19802565, PMID:20159618, PMID:25497060]
is_a: GO:0016236 ! macroautophagy
relationship: part_of GO:0098542 ! defense response to other organism

[Term]
id: GO:0098793
name: presynapse
namespace: cellular_component
def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos]
subset: goslim_synapse
synonym: "presynaptic terminal" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098794
name: postsynapse
namespace: cellular_component
def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos]
subset: goslim_synapse
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098795
name: global gene silencing by mRNA cleavage
namespace: biological_process
alt_id: GO:0030423
def: "A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner." [PMID:15009896]
synonym: "gene silencing by mRNA cleavage" BROAD []
synonym: "mRNA cleavage involved in gene silencing" BROAD []
synonym: "mRNA destabilization-mediated gene silencing" RELATED []
synonym: "RNA interference, targeting of mRNA for destruction" RELATED [GOC:mah]
synonym: "targeting of mRNA for destruction involved in RNA interference" RELATED []
is_a: GO:0016441 ! post-transcriptional gene silencing

[Term]
id: GO:0098796
name: membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of a membrane." [GOC:dos]
subset: goslim_metagenomics
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0098797
name: plasma membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane." [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0098798
name: mitochondrial protein-containing complex
namespace: cellular_component
def: "A protein complex that is part of a mitochondrion." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "mitochondrial protein complex" RELATED []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0098799
name: outer mitochondrial membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0098800
name: inner mitochondrial membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0098801
name: regulation of renal system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos]
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0003014 ! renal system process

[Term]
id: GO:0098802
name: plasma membrane signaling receptor complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0043235 ! receptor complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0098803
name: respiratory chain complex
namespace: cellular_component
def: "Any protein complex that is part of a respiratory chain." [GOC:dos]
synonym: "respirasome" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0098804
name: non-motile cilium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a non-motile cilium." [GOC:cilia, GOC:dos]
synonym: "nonmotile primary cilium membrane" RELATED []
is_a: GO:0060170 ! ciliary membrane
relationship: part_of GO:0097730 ! non-motile cilium

[Term]
id: GO:0098806
name: obsolete miRNA-mediated gene silencing by mRNA deadenylation
namespace: biological_process
def: "OBSOLETE. An RNA interference pathway in which a miRNA binding to mRNA triggers shortening of the poly(A) tail of a nuclear-transcribed mRNA, resulting in destabilization of the mRNA and a reduction the amount of translated transcript." [GOC:BHF, GOC:dos, PMID:21118121, PMID:23209154]
comment: This term was obsoleted because it represents the same process as miRNA-mediated gene silencing by mRNA destabilization ; GO:0035279.
synonym: "deadenylation involved in gene silencing by miRNA" EXACT []
synonym: "mRNA deadenylation-mediated gene silencing by miRNA" EXACT []
is_obsolete: true
replaced_by: GO:0035279

[Term]
id: GO:0098807
name: chloroplast thylakoid membrane protein complex
namespace: cellular_component
def: "A protein complex that is part of a chloroplast thylakoid membrane." [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0098808
name: mRNA cap binding
namespace: molecular_function
def: "Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule." [GOC:dos]
is_a: GO:0000339 ! RNA cap binding
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0098809
name: nitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor." [GOC:dos, GOC:jh]
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0098810
name: neurotransmitter reuptake
namespace: biological_process
def: "The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0098811
name: obsolete transcriptional repressor activity, RNA polymerase II activating transcription factor binding
namespace: molecular_function
def: "OBSOLETE. Binding to an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription." [GOC:BHF, GOC:dos, GOC:rl, GOC:txnOH]
comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent.
synonym: "RNA polymerase II activating transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "RNA polymerase II activating transcription factor binding transcription repressor activity" EXACT []
synonym: "RNA polymerase II transcription repressor activity" BROAD []
is_obsolete: true
consider: GO:0001227

[Term]
id: GO:0098812
name: obsolete nuclear rRNA polyadenylation involved in polyadenylation-dependent rRNA catabolic process
namespace: biological_process
def: "OBSOLETE. The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a rRNA, occurring as part of the process of polyadenylation-dependent rRNA catabolism in the nucleus." [GOC:dph, GOC:jl, GOC:tb]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "nuclear rRNA polyadenylation during polyadenylation-dependent rRNA catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nuclear rRNA polyadenylation involved in poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw]
is_obsolete: true
replaced_by: GO:0043633

[Term]
id: GO:0098813
name: nuclear chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos]
is_a: GO:0007059 ! chromosome segregation

[Term]
id: GO:0098814
name: spontaneous synaptic transmission
namespace: biological_process
def: "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential." [PMID:20200227]
comment: This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
subset: goslim_synapse
synonym: "basal synaptic transmission" EXACT [PMID:16899074]
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0098815
name: modulation of excitatory postsynaptic potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dos]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:0098816
name: mini excitatory postsynaptic potential
namespace: biological_process
def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:dos]
is_a: GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:0098817
name: evoked excitatory postsynaptic potential
namespace: biological_process
def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse." [GOC:dos]
is_a: GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:0098818
name: hyperpolarization of postsynaptic membrane
namespace: biological_process
def: "A process that hyerpolarizes a postsynaptic membrane relative to its resting potential. This has an inhibitory effect on the post-synaptic cell, moving the membrane potential away from the firing threshold." [GOC:dos]
is_a: GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0098819
name: depolarization of postsynaptic membrane
namespace: biological_process
def: "A process that depolarizes a postsynaptic membrane relative to its resting potential. This has an excitatory effect on the post-synaptic cell, moving the membrane potential towards the firing threshold." [GOC:dos]
is_a: GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0098820
name: trans-synaptic protein complex
namespace: cellular_component
def: "A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes." [PMID:20200227]
subset: goslim_synapse
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0098821
name: BMP receptor activity
namespace: molecular_function
def: "Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity." [GOC:BHF, GOC:dos]
is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity

[Term]
id: GO:0098822
name: obsolete peptidyl-cysteine modification to L-cysteine persulfide
namespace: biological_process
def: "OBSOLETE. The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide." [PMID:11592406]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0098823
name: obsolete peptidyl-cysteine modification to S-amindino-L-cysteine
namespace: biological_process
def: "OBSOLETE. The amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0098824
name: obsolete peptidyl-cysteine sulfation
namespace: biological_process
def: "OBSOLETE. The sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0098825
name: obsolete peptidyl-histidine guanylation
namespace: biological_process
def: "OBSOLETE. The guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0098826
name: endoplasmic reticulum tubular network membrane
namespace: cellular_component
def: "The membrane of the endoplasmic reticulum tubular network." [PMID:16469703]
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0071782 ! endoplasmic reticulum tubular network

[Term]
id: GO:0098827
name: endoplasmic reticulum subcompartment
namespace: cellular_component
def: "A distinct region of the endoplasmic reticulum." [GOC:dos]
is_a: GO:0031984 ! organelle subcompartment
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0098828
name: modulation of inhibitory postsynaptic potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dos]
synonym: "regulation of inhibitory postsynaptic potential" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0042391 ! regulation of membrane potential
relationship: regulates GO:0060080 ! inhibitory postsynaptic potential

[Term]
id: GO:0098829
name: intestinal folate absorption
namespace: biological_process
def: "Uptake of folic into the blood by absorption from the small intestine." [GOC:BHF, GOC:dos, GOC:hal, PMID:19762432]
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0098830
name: presynaptic endosome
namespace: cellular_component
def: "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles." [PMID:20200227, PMID:25939282]
comment: As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details.
subset: goslim_synapse
is_a: GO:0005768 ! endosome
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0098831
name: presynaptic active zone cytoplasmic component
namespace: cellular_component
def: "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles." [GOC:dos]
subset: goslim_synapse
synonym: "cortex of presynaptic active zone" EXACT []
synonym: "presynaptic zone cortex" EXACT []
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0098832
name: peri-centrosomal recycling endosome
namespace: cellular_component
def: "A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes." [PMID:19696797, PMID:20820847]
is_a: GO:0055037 ! recycling endosome

[Term]
id: GO:0098833
name: presynaptic endocytic zone
namespace: cellular_component
def: "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity." [PMID:17455288]
comment: May be identical to periactive zone?
subset: goslim_synapse
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0098834
name: presynaptic endocytic zone cytoplasmic component
namespace: cellular_component
def: "The cytoplasmic component of the presynaptic endocytic zone." [GOC:dos]
subset: goslim_synapse
synonym: "cortex of presynaptic endocytic zone" EXACT []
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0098833 ! presynaptic endocytic zone

[Term]
id: GO:0098835
name: presynaptic endocytic zone membrane
namespace: cellular_component
def: "The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane
relationship: part_of GO:0098833 ! presynaptic endocytic zone

[Term]
id: GO:0098836
name: cytoskeleton of dendritic spine
namespace: cellular_component
def: "The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodeling in response to postsynaptic signaling." [PMID:24854120]
is_a: GO:0099571 ! postsynaptic cytoskeleton
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0098837
name: postsynaptic recycling endosome
namespace: cellular_component
def: "A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation." [PMID:20820847]
subset: goslim_synapse
synonym: "postsynaptic endosomal recycling compartment" BROAD [PMID:20820847]
synonym: "postsynaptic recycling outpost" EXACT [PMID:20820847]
is_a: GO:0055037 ! recycling endosome
is_a: GO:0098845 ! postsynaptic endosome

[Term]
id: GO:0098838
name: folate transmembrane transport
namespace: biological_process
def: "The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane." [PMID:24745983]
synonym: "folic acid transmembrane transport" RELATED []
synonym: "reduced folate transmembrane transport" NARROW []
is_a: GO:0015884 ! folic acid transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0098839
name: postsynaptic density membrane
namespace: cellular_component
def: "The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099634 ! postsynaptic specialization membrane
relationship: part_of GO:0014069 ! postsynaptic density

[Term]
id: GO:0098840
name: protein transport along microtubule
namespace: biological_process
def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607]
synonym: "microtubule-based protein transport" BROAD []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0099118 ! microtubule-based protein transport

[Term]
id: GO:0098841
name: protein localization to cell division site after cytokinesis
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis." [PMID:25411334]
is_a: GO:0072741 ! protein localization to cell division site

[Term]
id: GO:0098842
name: postsynaptic early endosome
namespace: cellular_component
def: "An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling." [PMID:19603039, PMID:20820847, PMID:24727350]
comment: Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1.
subset: goslim_synapse
is_a: GO:0005769 ! early endosome
is_a: GO:0098845 ! postsynaptic endosome

[Term]
id: GO:0098843
name: postsynaptic endocytic zone
namespace: cellular_component
def: "A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892]
subset: goslim_synapse
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098844
name: postsynaptic endocytic zone membrane
namespace: cellular_component
def: "The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta." [PMID:17880892]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0098843 ! postsynaptic endocytic zone

[Term]
id: GO:0098845
name: postsynaptic endosome
namespace: cellular_component
def: "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse." [PMID:20820847]
subset: goslim_synapse
is_a: GO:0005768 ! endosome
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098846
name: podocyte foot
namespace: cellular_component
def: "A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms." [PMID:25324828]
synonym: "pedicel" EXACT [Wikipedia:Podocyte]
synonym: "podocyte foot process" EXACT [PMID:25324828]
synonym: "secondary podocyte projection" EXACT []
xref: Wikipedia:Podocyte
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0098847
name: sequence-specific single stranded DNA binding
namespace: molecular_function
def: "Binding to single-stranded DNA of a specific nucleotide composition." [PMID:9531483]
is_a: GO:0003697 ! single-stranded DNA binding
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0098848
name: alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane." [EC:4.7.1.1, GOC:dos, GOC:ik]
synonym: "alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)" RELATED [EC:4.7.1.1]
xref: EC:4.7.1.1
xref: RHEA:34707
is_a: GO:0018835 ! carbon phosphorus lyase activity

[Term]
id: GO:0098849
name: cellular detoxification of cadmium ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw]
is_a: GO:0071585 ! detoxification of cadmium ion
is_a: GO:0140961 ! cellular detoxification of metal ion
relationship: part_of GO:0071276 ! cellular response to cadmium ion

[Term]
id: GO:0098850
name: extrinsic component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0098851
name: double-stranded miRNA binding
namespace: molecular_function
def: "Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19966796]
synonym: "miRNA duplex binding" EXACT []
is_a: GO:0003725 ! double-stranded RNA binding

[Term]
id: GO:0098852
name: lytic vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000323 ! lytic vacuole

[Term]
id: GO:0098853
name: endoplasmic reticulum-vacuole membrane contact site
namespace: cellular_component
def: "A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes." [GOC:dos, PMID:26283797]
synonym: "ER-vacuole membrane contact site" EXACT []
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0098854
name: podocyte primary projection
namespace: cellular_component
def: "A cell projection originating from a renal glomerular podocyte and extending to the renal glomerular podocyte foot." [PMID:24309184, PMID:25324828]
synonym: "glomerular visceral epithelial cell primary projection" EXACT []
synonym: "podocyte major process" EXACT []
synonym: "primary podocyte process" EXACT []
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0098855
name: HCN channel complex
namespace: cellular_component
alt_id: GO:1990746
alt_id: GO:1990759
def: "A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart." [PMID:20829353]
synonym: "HCN1 channel complex" NARROW []
synonym: "HCN2 channel complex" NARROW []
synonym: "HCN3 channel complex" NARROW []
synonym: "HCN4 channel complex" NARROW []
synonym: "K/Na hyperpolarization-activated channel 3 complex" NARROW []
synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW []
synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW []
synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW []
synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT []
synonym: "potassium/sodium hyperpolarization-activated channel 3 complex" NARROW []
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW []
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW []
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer" RELATED []
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW []
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer" RELATED []
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT []
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0098856
name: intestinal lipid absorption
namespace: biological_process
def: "A process in which lipids are taken up from the contents of the intestine." [GOC:dos, GOC:sl, PMID:18768481]
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0098857
name: membrane microdomain
namespace: cellular_component
def: "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820]
is_a: GO:0016020 ! membrane

[Term]
id: GO:0098858
name: actin-based cell projection
namespace: cellular_component
def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0098859
name: actin filament bundle of actin-based cell projection
namespace: cellular_component
def: "A bundle of cross-linked actin filaments that is part of an actin-based cell protrusion, in which filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which stabilizes the filaments." [PMID:12566431, PMID:15661519]
is_a: GO:0097518 ! parallel actin filament bundle
relationship: part_of GO:0098858 ! actin-based cell projection

[Term]
id: GO:0098860
name: actin filament bundle of stereocilium
namespace: cellular_component
def: "A bundle of hundreds of cross-linked actin filaments (an actin cable), that is the supporting structure of a stereocilium. Filaments are oriented such that the the plus (barbed) ends are at the tip of the protrusion and are capped by a tip complex which bridges to the plasma membrane." [PMID:15661519]
is_a: GO:0098859 ! actin filament bundle of actin-based cell projection
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0098861
name: actin filament bundle of filopodium
namespace: cellular_component
def: "A parallel bundle of actin filaments that is part of filopodium. Filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex." [PMID:12566431]
is_a: GO:0098859 ! actin filament bundle of actin-based cell projection
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0098862
name: cluster of actin-based cell projections
namespace: cellular_component
def: "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0098863
name: nuclear migration by microtubule mediated pushing forces
namespace: biological_process
def: "The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules." [GOC:vw, PMID:11309419, PMID:16611238]
is_a: GO:0007097 ! nuclear migration
is_a: GO:0099098 ! microtubule polymerization based movement
is_a: GO:0099111 ! microtubule-based transport

[Term]
id: GO:0098864
name: symbiont-mediated stabilization of host tight cell-cell junction
namespace: biological_process
def: "The process in which a symbiont organism that stabilizes the its host tight cell-cell junctions, making them less dynamic. The tight junction is a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other, and plays a role in the inflammatory response of the host." [PMID:25838979]
synonym: "modification by symbiont of host tight cell-cell junction" BROAD []
synonym: "stabilization of host tight cell-cell junction" BROAD []
is_a: GO:0098865 ! symbiont-mediated perturbation of host tight cell-cell junction

[Term]
id: GO:0098865
name: symbiont-mediated perturbation of host tight cell-cell junction
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or temporarily subverts the tight cell-cell junctions between cells of the host. Tight cell-cell junctions, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [PMID:24287273]
synonym: "disruption by symbiont of host tight cell-cell junction" EXACT []
synonym: "disruption of host tight cell-cell junction" BROAD []
synonym: "modification by symbiont of host bicellular tight junctions" RELATED []
synonym: "symbiont-mediated disruption of host tight cell-cell junction" RELATED []
is_a: GO:0044067 ! symbiont-mediated perturbation of host cell-cell junction

[Term]
id: GO:0098866
name: multivesicular body fusion to apical plasma membrane
namespace: biological_process
def: "The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell." [PMID:26459596]
is_a: GO:0099500 ! vesicle fusion to plasma membrane
relationship: part_of GO:1990182 ! exosomal secretion

[Term]
id: GO:0098867
name: intramembranous bone growth
namespace: biological_process
def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686]
is_a: GO:0098868 ! bone growth

[Term]
id: GO:0098868
name: bone growth
namespace: biological_process
def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0098869
name: cellular oxidant detoxification
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw]
is_a: GO:1990748 ! cellular detoxification

[Term]
id: GO:0098870
name: action potential propagation
namespace: biological_process
def: "The propagation of an action potential along the plane of an excitable membrane. Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold." [GOC:dos]
is_a: GO:0001508 ! action potential

[Term]
id: GO:0098871
name: postsynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015629 ! actin cytoskeleton
is_a: GO:0099571 ! postsynaptic cytoskeleton

[Term]
id: GO:0098872
name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT []
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
is_a: GO:0099583 ! neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0098873
name: neuronal action potential back-propagation
namespace: biological_process
def: "Propagation of an action potential in a neuron, from its site of initiation (typically the axon hillock) towards the soma." [GOC:dos]
is_a: GO:0098870 ! action potential propagation

[Term]
id: GO:0098874
name: spike train
namespace: biological_process
alt_id: GO:0099603
def: "A series of sequential, propagated action potentials occurring in a single cell." [ISBN:978-0071390118]
synonym: "burst of action potentials" EXACT []
synonym: "spike-train" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0098875
name: epididymosome
namespace: cellular_component
def: "A microvesicle of the epididymal fluid, from which spermatozoa acquire membrane proteins." [GOC:dos, GOC:mg, PMID:23177142, PMID:26112475]
is_a: GO:1990742 ! microvesicle

[Term]
id: GO:0098876
name: vesicle-mediated transport to the plasma membrane
namespace: biological_process
def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0098877
name: neurotransmitter receptor transport to plasma membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane
is_a: GO:0099637 ! neurotransmitter receptor transport
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0098878
name: neurotransmitter receptor complex
namespace: cellular_component
def: "Any protein complex that is capable of functioning as a neurotransmitter receptor." [GOC:dos]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:0098879
name: structural constituent of postsynaptic specialization
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic specialization." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099186 ! structural constituent of postsynapse

[Term]
id: GO:0098880
name: maintenance of postsynaptic specialization structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins in the presynaptic specialization." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097106 ! postsynaptic density organization
is_a: GO:0099558 ! maintenance of synapse structure

[Term]
id: GO:0098881
name: exocytic insertion of neurotransmitter receptor to plasma membrane
namespace: biological_process
def: "The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion." [GOC:aruk, GOC:bc, PMID:19503082]
subset: goslim_synapse
synonym: "neurotransmitter receptor insertion" EXACT []
is_a: GO:0006904 ! vesicle docking involved in exocytosis
is_a: GO:0090522 ! vesicle tethering involved in exocytosis
relationship: part_of GO:0098877 ! neurotransmitter receptor transport to plasma membrane

[Term]
id: GO:0098882
name: structural constituent of presynaptic active zone
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a presynaptic active zone." [GOC:dos]
subset: goslim_synapse
synonym: "structural constituent of active zone" EXACT syngo_official_label []
is_a: GO:0098918 ! structural constituent of synapse

[Term]
id: GO:0098883
name: synapse pruning
namespace: biological_process
def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190]
subset: goslim_synapse
synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
synonym: "synapse disassembly" EXACT syngo_official_label [PMID:12062020]
synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190]
synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
is_a: GO:0050808 ! synapse organization
is_a: GO:0150146 ! cell junction disassembly

[Term]
id: GO:0098884
name: postsynaptic neurotransmitter receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label []
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
is_a: GO:0099590 ! neurotransmitter receptor internalization
is_a: GO:0140239 ! postsynaptic endocytosis

[Term]
id: GO:0098885
name: modification of postsynaptic actin cytoskeleton
namespace: biological_process
def: "Any process that modifies the structure of a postsynaptic actin cytoskeleton." [GOC:dos]
comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
subset: goslim_synapse
synonym: "postsynaptic actin cytoskeleton remodelling" EXACT []
is_a: GO:0099010 ! modification of postsynaptic structure

[Term]
id: GO:0098886
name: modification of dendritic spine
namespace: biological_process
def: "Any process that modifies the structure of a dendritic spine." [GOC:dos]
comment: This class does not cover assembly or disassembly of dendritic spines, only the modification/remodelling of existing ones.
is_a: GO:0099010 ! modification of postsynaptic structure

[Term]
id: GO:0098887
name: neurotransmitter receptor transport, endosome to postsynaptic membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD []
is_a: GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane
is_a: GO:0099639 ! neurotransmitter receptor transport, endosome to plasma membrane

[Term]
id: GO:0098888
name: extrinsic component of presynaptic membrane
namespace: cellular_component
def: "The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
synonym: "extrinsic component of presynaptic plasma membrane" EXACT []
is_a: GO:0099243 ! extrinsic component of synaptic membrane
relationship: part_of GO:0042734 ! presynaptic membrane

[Term]
id: GO:0098889
name: obsolete intrinsic component of presynaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to presynaptic membrane" NARROW []
is_obsolete: true
replaced_by: GO:0042734

[Term]
id: GO:0098890
name: extrinsic component of postsynaptic membrane
namespace: cellular_component
def: "The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0099243 ! extrinsic component of synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane

[Term]
id: GO:0098891
name: extrinsic component of presynaptic active zone membrane
namespace: cellular_component
def: "The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098888 ! extrinsic component of presynaptic membrane
relationship: part_of GO:0048787 ! presynaptic active zone membrane

[Term]
id: GO:0098892
name: extrinsic component of postsynaptic specialization membrane
namespace: cellular_component
def: "The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098890 ! extrinsic component of postsynaptic membrane
relationship: part_of GO:0099634 ! postsynaptic specialization membrane

[Term]
id: GO:0098893
name: extrinsic component of postsynaptic endocytic zone
namespace: cellular_component
def: "The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098890 ! extrinsic component of postsynaptic membrane
relationship: part_of GO:0098844 ! postsynaptic endocytic zone membrane

[Term]
id: GO:0098894
name: extrinsic component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098888 ! extrinsic component of presynaptic membrane
relationship: part_of GO:0098835 ! presynaptic endocytic zone membrane

[Term]
id: GO:0098895
name: postsynaptic endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a postsynaptic endosome." [GOC:pz]
subset: goslim_synapse
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0098845 ! postsynaptic endosome

[Term]
id: GO:0098896
name: postsynaptic early endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a postsynaptic early endosome." [GOC:pz]
subset: goslim_synapse
is_a: GO:0031901 ! early endosome membrane
is_a: GO:0098895 ! postsynaptic endosome membrane
relationship: part_of GO:0098842 ! postsynaptic early endosome

[Term]
id: GO:0098897
name: spine apparatus membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the spine apparatus." [GOC:mah]
subset: goslim_synapse
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0097444 ! spine apparatus

[Term]
id: GO:0098898
name: dense core granule lumen
namespace: cellular_component
def: "The volume enclosed by the dense core granule membrane." [GOC:dos]
synonym: "dense core vesicle lumen" EXACT []
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0031045 ! dense core granule

[Term]
id: GO:0098899
name: spine apparatus lumen
namespace: cellular_component
def: "The volume enclosed by the spine apparatus membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0097444 ! spine apparatus

[Term]
id: GO:0098900
name: regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term.
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0001508 ! action potential

[Term]
id: GO:0098901
name: regulation of cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098900 ! regulation of action potential
relationship: regulates GO:0086001 ! cardiac muscle cell action potential

[Term]
id: GO:0098902
name: regulation of membrane depolarization during action potential
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]
is_a: GO:0003254 ! regulation of membrane depolarization
relationship: regulates GO:0086010 ! membrane depolarization during action potential

[Term]
id: GO:0098903
name: regulation of membrane repolarization during action potential
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]
is_a: GO:0060306 ! regulation of membrane repolarization
is_a: GO:0098900 ! regulation of action potential
relationship: regulates GO:0086011 ! membrane repolarization during action potential

[Term]
id: GO:0098904
name: regulation of AV node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "regulation of AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
relationship: regulates GO:0086016 ! AV node cell action potential

[Term]
id: GO:0098905
name: regulation of bundle of His cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
relationship: regulates GO:0086043 ! bundle of His cell action potential

[Term]
id: GO:0098906
name: regulation of Purkinje myocyte action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
relationship: regulates GO:0086017 ! Purkinje myocyte action potential

[Term]
id: GO:0098907
name: regulation of SA node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
relationship: regulates GO:0086015 ! SA node cell action potential

[Term]
id: GO:0098908
name: regulation of neuronal action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051969 ! regulation of transmission of nerve impulse
is_a: GO:0098900 ! regulation of action potential
relationship: regulates GO:0019228 ! neuronal action potential

[Term]
id: GO:0098909
name: regulation of cardiac muscle cell action potential involved in regulation of contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
relationship: part_of GO:0086004 ! regulation of cardiac muscle cell contraction

[Term]
id: GO:0098910
name: regulation of atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086004 ! regulation of cardiac muscle cell contraction
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:1903779 ! regulation of cardiac conduction
relationship: regulates GO:0086014 ! atrial cardiac muscle cell action potential

[Term]
id: GO:0098911
name: regulation of ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086004 ! regulation of cardiac muscle cell contraction
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
relationship: regulates GO:0086005 ! ventricular cardiac muscle cell action potential

[Term]
id: GO:0098912
name: membrane depolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "atrial cardiac muscle cell depolarization" BROAD [GOC:dph, GOC:tb]
synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential

[Term]
id: GO:0098913
name: membrane depolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential

[Term]
id: GO:0098914
name: membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
is_a: GO:0099624 ! atrial cardiac muscle cell membrane repolarization
relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential

[Term]
id: GO:0098915
name: membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
is_a: GO:0099625 ! ventricular cardiac muscle cell membrane repolarization
relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential

[Term]
id: GO:0098916
name: anterograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0098917
name: retrograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft." [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0098918
name: structural constituent of synapse
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0098919
name: structural constituent of postsynaptic density
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098879 ! structural constituent of postsynaptic specialization

[Term]
id: GO:0098920
name: retrograde trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099541 ! trans-synaptic signaling by lipid

[Term]
id: GO:0098921
name: retrograde trans-synaptic signaling by endocannabinoid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098920 ! retrograde trans-synaptic signaling by lipid
is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid

[Term]
id: GO:0098922
name: extrinsic component of dense core granule membrane
namespace: cellular_component
def: "The component of the dense core granule membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
is_a: GO:0031312 ! extrinsic component of organelle membrane
relationship: part_of GO:0032127 ! dense core granule membrane

[Term]
id: GO:0098923
name: retrograde trans-synaptic signaling by soluble gas
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0098924
name: retrograde trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098923 ! retrograde trans-synaptic signaling by soluble gas
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide

[Term]
id: GO:0098925
name: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
namespace: biological_process
def: "Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0098924 ! retrograde trans-synaptic signaling by nitric oxide
is_a: GO:0099555 ! trans-synaptic signaling by nitric oxide, modulating synaptic transmission

[Term]
id: GO:0098926
name: postsynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic signaling pathway" EXACT syngo_official_label []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0098927
name: vesicle-mediated transport between endosomal compartments
namespace: biological_process
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome." [GOC:dos, PMID:10930469]
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0098928
name: presynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "presynaptic signaling pathway" EXACT syngo_official_label []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0098929
name: obsolete extrinsic component of spine apparatus membrane
namespace: cellular_component
def: "OBSOLETE. The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
consider: GO:0098897

[Term]
id: GO:0098930
name: axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" EXACT []
synonym: "axoplasmic transport" EXACT []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0008088 ! axo-dendritic transport

[Term]
id: GO:0098931
name: virion attachment to host cell flagellum
namespace: biological_process
def: "The process by which a virion attaches to a the host cell flagellum. Some DNA bacterial viruses use flagella to attach to the host cell. This contact with the flagellum facilitates concentration of phage particles around the entry receptor on the bacterial cell surface." [GOC:dos, VZ:3949]
xref: VZ:3949
is_a: GO:0019062 ! virion attachment to host cell

[Term]
id: GO:0098932
name: symbiont entry into host cell via disruption of host cell wall peptidoglycan
namespace: biological_process
def: "The disruption by a symbiont of host cell wall peptidoglycans to allow entry into the host cell." [GOC:dos, VZ:3940]
synonym: "catabolism of host cell wall peptidoglycan by virus" EXACT []
synonym: "degradation of host cell wall peptidoglycan by virus" EXACT []
synonym: "degradation of host peptidoglycans during virus entry" EXACT [VZ:3940]
synonym: "disassembly by virus of host cell wall peptidoglycan" EXACT []
synonym: "disruption by virus of host cell wall peptidoglycan during virus entry" EXACT []
xref: VZ:3940
is_a: GO:0052009 ! symbiont-mediated disruption of host cell wall
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0098933
name: symbiont-mediated disruption of host cell envelope
namespace: biological_process
def: "The process in which a symbiont effects a change that impairs the structure or function of the host cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "disruption by symbiont of host cell envelope" EXACT []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0098934
name: retrograde dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098935
name: dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in dendrites." [ISBN:0815316194]
subset: goslim_synapse
synonym: "dendrite cargo transport" EXACT []
is_a: GO:0008088 ! axo-dendritic transport

[Term]
id: GO:0098936
name: obsolete intrinsic component of postsynaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic membrane" NARROW []
is_obsolete: true
replaced_by: GO:0045211

[Term]
id: GO:0098937
name: anterograde dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194]
subset: goslim_synapse
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098938
name: actin cytoskeleton of dendritic spine
namespace: cellular_component
def: "The actin cytoskeleton that is part of a dendritic spine." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098836 ! cytoskeleton of dendritic spine
is_a: GO:0098871 ! postsynaptic actin cytoskeleton

[Term]
id: GO:0098939
name: dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell dendrites." [GOC:ai]
subset: goslim_synapse
is_a: GO:0047497 ! mitochondrion transport along microtubule
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098940
name: anterograde trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098916 ! anterograde trans-synaptic signaling
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide

[Term]
id: GO:0098941
name: anterograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098916 ! anterograde trans-synaptic signaling
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex

[Term]
id: GO:0098942
name: retrograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex

[Term]
id: GO:0098943
name: neurotransmitter receptor transport, postsynaptic endosome to lysosome
namespace: biological_process
def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0008333 ! endosome to lysosome transport
is_a: GO:0061462 ! protein localization to lysosome
is_a: GO:0072666 ! establishment of protein localization to vacuole
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0098944
name: postsynaptic recycling endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a postsynaptic recycling endosome." [GOC:pz]
subset: goslim_synapse
is_a: GO:0098895 ! postsynaptic endosome membrane
relationship: part_of GO:0098837 ! postsynaptic recycling endosome

[Term]
id: GO:0098945
name: obsolete intrinsic component of presynaptic active zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to presynaptic active zone membrane" NARROW []
is_obsolete: true
replaced_by: GO:0048787

[Term]
id: GO:0098946
name: obsolete intrinsic component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to presynaptic active zone membrane" NARROW []
is_obsolete: true
replaced_by: GO:0098835

[Term]
id: GO:0098947
name: obsolete intrinsic component of postsynaptic endocytic zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic active zone membrane" NARROW []
is_obsolete: true
replaced_by: GO:0098844

[Term]
id: GO:0098948
name: obsolete intrinsic component of postsynaptic specialization membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic specialization membrane" NARROW []
is_obsolete: true
replaced_by: GO:0099634

[Term]
id: GO:0098949
name: obsolete intrinsic component of postsynaptic endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic endosome membrane" NARROW []
is_obsolete: true
replaced_by: GO:0098895

[Term]
id: GO:0098950
name: obsolete intrinsic component of postsynaptic early endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic early endosome membrane" NARROW []
is_obsolete: true
replaced_by: GO:0098896

[Term]
id: GO:0098951
name: obsolete intrinsic component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic recycling endosome membrane" EXACT []
is_obsolete: true
replaced_by: GO:0098944

[Term]
id: GO:0098952
name: obsolete intrinsic component of spine apparatus membrane
namespace: cellular_component
def: "OBSOLETE. The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to spine apparatus membrane" EXACT []
is_obsolete: true
replaced_by: GO:0098897

[Term]
id: GO:0098953
name: receptor diffusion trapping
namespace: biological_process
def: "The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix." [PMID:18832033]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0098954
name: presynaptic endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a presynaptic endosome." [GOC:pz]
subset: goslim_synapse
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0098830 ! presynaptic endosome

[Term]
id: GO:0098955
name: obsolete intrinsic component of presynaptic endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to presynaptic endosome membrane" EXACT []
is_obsolete: true
replaced_by: GO:0098954

[Term]
id: GO:0098956
name: obsolete intrinsic component of dense core granule membrane
namespace: cellular_component
def: "OBSOLETE. The component of the dense core granule membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to dense core granule membrane" EXACT []
is_obsolete: true
replaced_by: GO:0032127

[Term]
id: GO:0098957
name: anterograde axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde axon transport of mitochondria" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0019896 ! axonal transport of mitochondrion

[Term]
id: GO:0098958
name: retrograde axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "retrograde axon transport of mitochondria" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0019896 ! axonal transport of mitochondrion

[Term]
id: GO:0098959
name: retrograde dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "retrograde dendrite transport of mitochondria" EXACT []
is_a: GO:0098939 ! dendritic transport of mitochondrion

[Term]
id: GO:0098960
name: postsynaptic neurotransmitter receptor activity
namespace: molecular_function
def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane during synaptic transmission." [GOC:dos, GOC:signaling]
synonym: "neurotransmitter receptor activity involved in chemical synaptic transmission" EXACT []
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0098961
name: dendritic transport of ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos]
subset: goslim_synapse
synonym: "dendritic transport of RNP complex" EXACT []
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098962
name: regulation of postsynaptic neurotransmitter receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos]
subset: gocheck_obsoletion_candidate
subset: goslim_synapse
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity

[Term]
id: GO:0098963
name: dendritic transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos]
subset: goslim_synapse
synonym: "dendritic transport of mRNA RNP complex" EXACT []
is_a: GO:0098935 ! dendritic transport

[Term]
id: GO:0098964
name: anterograde dendritic transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde dendritic transport of mRNA RNP complex" EXACT []
is_a: GO:0098937 ! anterograde dendritic transport

[Term]
id: GO:0098965
name: extracellular matrix of synaptic cleft
namespace: cellular_component
def: "The portion of the extracellular matrix that lies within the synaptic cleft." [GOC:dos]
subset: goslim_synapse
synonym: "ECM of synaptic cleft" EXACT []
synonym: "synaptic cleft ECM" EXACT []
is_a: GO:0062023 ! collagen-containing extracellular matrix
relationship: part_of GO:0099535 ! synapse-associated extracellular matrix

[Term]
id: GO:0098966
name: perisynaptic extracellular matrix
namespace: cellular_component
def: "The portion of the extracellular matrix that lies within the perisynaptic space." [GOC:dos]
subset: goslim_synapse
synonym: "extrasynaptic extracellular matrix" EXACT []
synonym: "perisynaptic ECM" EXACT []
is_a: GO:0062023 ! collagen-containing extracellular matrix
relationship: part_of GO:0099535 ! synapse-associated extracellular matrix

[Term]
id: GO:0098967
name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane
namespace: biological_process
def: "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082]
subset: goslim_synapse
is_a: GO:0006887 ! exocytosis
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
relationship: part_of GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane

[Term]
id: GO:0098968
name: neurotransmitter receptor transport postsynaptic membrane to endosome
namespace: biological_process
def: "Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome." [GOC:dos]
subset: goslim_synapse
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0097120 ! receptor localization to synapse

[Term]
id: GO:0098969
name: neurotransmitter receptor transport to postsynaptic membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
is_a: GO:1903540 ! establishment of protein localization to postsynaptic membrane

[Term]
id: GO:0098970
name: postsynaptic neurotransmitter receptor diffusion trapping
namespace: biological_process
def: "The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization." [PMID:18832033]
subset: goslim_synapse
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
is_a: GO:0099628 ! neurotransmitter receptor diffusion trapping

[Term]
id: GO:0098971
name: anterograde dendritic transport of neurotransmitter receptor complex
namespace: biological_process
def: "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0098937 ! anterograde dendritic transport

[Term]
id: GO:0098972
name: anterograde dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098937 ! anterograde dendritic transport
is_a: GO:0098939 ! dendritic transport of mitochondrion

[Term]
id: GO:0098973
name: structural constituent of postsynaptic actin cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005200 ! structural constituent of cytoskeleton
is_a: GO:0099186 ! structural constituent of postsynapse

[Term]
id: GO:0098974
name: postsynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0099188 ! postsynaptic cytoskeleton organization

[Term]
id: GO:0098975
name: postsynapse of neuromuscular junction
namespace: cellular_component
def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502]
is_a: GO:0098794 ! postsynapse
relationship: part_of GO:0031594 ! neuromuscular junction

[Term]
id: GO:0098976
name: excitatory chemical synaptic transmission
namespace: biological_process
def: "Synaptic transmission that results in an excitatory postsynaptic potential." [GOC:dos]
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0098977
name: inhibitory chemical synaptic transmission
namespace: biological_process
def: "Synaptic transmission that results in an inhibitory postsynaptic potential." [GOC:dos]
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0098978
name: glutamatergic synapse
namespace: cellular_component
def: "A synapse that uses glutamate as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098979
name: polyadic synapse
namespace: cellular_component
def: "A synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems." [PMID:26780543]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098980
name: presynaptic density
namespace: cellular_component
def: "An electron dense specialization of the presynaptic active zone cytoskeleton." [GOC:dos, PMID:26780543]
is_a: GO:0048788 ! cytoskeleton of presynaptic active zone

[Term]
id: GO:0098981
name: cholinergic synapse
namespace: cellular_component
def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098982
name: GABA-ergic synapse
namespace: cellular_component
def: "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098983
name: symmetric, GABA-ergic, inhibitory synapse
namespace: cellular_component
def: "A neuron to neuron synapse that lacks an electron dense postsynaptic specialization, uses GABA as a neurotransmitter and whose activity results in inhibitory postsynaptic potentials." [GOC:dos]
is_a: GO:0032280 ! symmetric synapse
is_a: GO:0060077 ! inhibitory synapse
is_a: GO:0098982 ! GABA-ergic synapse

[Term]
id: GO:0098984
name: neuron to neuron synapse
namespace: cellular_component
def: "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0098985
name: asymmetric, glutamatergic, excitatory synapse
namespace: cellular_component
def: "A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials." [GOC:dos]
is_a: GO:0032279 ! asymmetric synapse
is_a: GO:0060076 ! excitatory synapse
is_a: GO:0098978 ! glutamatergic synapse

[Term]
id: GO:0098986
name: T-bar
namespace: cellular_component
def: "A T-shaped presynpatic density. These are common in arhropod central nervous systems." [GOC:dos, PMID:26780543]
is_a: GO:0098980 ! presynaptic density

[Term]
id: GO:0098987
name: regulation of modification of synapse structure, modulating synaptic transmission
namespace: biological_process
def: "Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:1905244 ! regulation of modification of synaptic structure

[Term]
id: GO:0098988
name: G protein-coupled glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [GOC:dos]
synonym: "G-protein coupled glutamate receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0008066 ! glutamate receptor activity

[Term]
id: GO:0098989
name: NMDA selective glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dos, ISBN:9780071120005]
is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway

[Term]
id: GO:0098990
name: AMPA selective glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:dos, ISBN:9780071120005]
subset: goslim_synapse
is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway

[Term]
id: GO:0098991
name: kainate selective glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:9780071120005]
subset: goslim_synapse
is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway

[Term]
id: GO:0098992
name: neuronal dense core vesicle
namespace: cellular_component
def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]
subset: goslim_synapse
is_a: GO:0031045 ! dense core granule

[Term]
id: GO:0098993
name: obsolete anchored component of synaptic vesicle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0030672

[Term]
id: GO:0098994
name: symbiont entry into host cell via disruption of host cell envelope
namespace: biological_process
def: "The disruption by a symbiont of host cell envelope components to allow entry into the host cell." [GOC:dos]
synonym: "disruption of host cell envelope during viral entry" EXACT []
xref: VZ:3938
is_a: GO:0098933 ! symbiont-mediated disruption of host cell envelope
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0098995
name: symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide
namespace: biological_process
def: "The disruption by a symbiont of host cell wall lipopolysaccharides to allow entry into the host cell. For example a phage entering a Gram-negative bacterium may actively break down outer membrane lipopolysaccharides." [GOC:dos, VZ:3940]
synonym: "degradation of host cell envelope lipopolysaccharide during viral entry" EXACT []
synonym: "degradation of host lipopolysaccharide during virus entry" EXACT [VZ:3940]
synonym: "disassembly by virus of outer membrane lipopolysaccharide during viral entry" NARROW []
synonym: "disruption by virus of host envelope lipopolysaccharide during virus entry" EXACT []
xref: VZ:3939
is_a: GO:0052009 ! symbiont-mediated disruption of host cell wall
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0098996
name: symbiont entry into host cell via disruption of host cell glycocalyx
namespace: biological_process
def: "The disruption by a symbiont of host cell capsule to allow entry into the host cell." [GOC:dos]
synonym: "catabolism of host glycocalyx during viral entry" EXACT []
synonym: "degradation of host capsule during virus entry" EXACT [VZ:3896]
synonym: "degradation of host glycocalyx during viral entry" EXACT []
synonym: "disassembly of glycocalyx during viral entry" EXACT []
synonym: "disruption of host cell glycocalyx during viral entry" EXACT []
synonym: "symbiont entry into host cell by disruption of host cell capsule" EXACT []
xref: VZ:3938
is_a: GO:0098933 ! symbiont-mediated disruption of host cell envelope
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0098997
name: fusion of virus membrane with host outer membrane
namespace: biological_process
def: "Fusion of a viral membrane with the host cell outer membrane during viral entry." [GOC:dos, VZ:3941]
synonym: "fusion of viral membrane with host outer membrane" RELATED [GOC:dos, VZ:3941]
synonym: "viral envelope fusion" BROAD []
synonym: "viral envelope fusion with host outer membrane" EXACT []
synonym: "viral penetration via membrane fusion" BROAD []
synonym: "viral-cell fusion molecule activity" RELATED []
xref: VZ:3941 "Fusion of virus membrane with host cell membrane"
is_a: GO:0019064 ! fusion of virus membrane with host plasma membrane

[Term]
id: GO:0098998
name: extrinsic component of postsynaptic early endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane
relationship: part_of GO:0098896 ! postsynaptic early endosome membrane

[Term]
id: GO:0098999
name: extrinsic component of postsynaptic endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0031313 ! extrinsic component of endosome membrane
relationship: part_of GO:0098895 ! postsynaptic endosome membrane

[Term]
id: GO:0099000
name: symbiont genome ejection through host cell envelope, contractile tail mechanism
namespace: biological_process
def: "Entry of a symbiont's genome into the host cell through the host cell envelope via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. Occurs in non-enveloped prokaryotic viruses." [GOC:dos, PMID:26283379, VZ:3950]
synonym: "viral contractile tail ejection system" EXACT [VZ:3950]
synonym: "viral genome ejection through host cell envelope, contractile tail mechanism" RELATED []
xref: VZ:3950 "Viral contractile tail ejection system"
is_a: GO:0039678 ! symbiont genome ejection through host cell envelope

[Term]
id: GO:0099001
name: symbiont genome ejection through host cell envelope, long flexible tail mechanism
namespace: biological_process
def: "Entry of a symbiont's genome into the host cell through the host cell envelope via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm. Occurs in non-enveloped prokaryotic viruses." [GOC:dos, PMID:22297512, VZ:3952]
synonym: "viral genome ejection through host cell envelope, long flexible tail mechanism" RELATED []
synonym: "viral long flexible tail ejection system" EXACT [VZ:3952]
xref: VZ:3952 "Viral long flexible tail ejection system"
is_a: GO:0039678 ! symbiont genome ejection through host cell envelope

[Term]
id: GO:0099002
name: symbiont genome ejection through host cell envelope, short tail mechanism
namespace: biological_process
def: "Entry of a symbiont's genome into the host cell through the host cell envelope via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties. Occurs in non-enveloped prokaryotic viruses." [GOC:dos, PMID:22297513, VZ:3954]
synonym: "viral genome ejection through host cell envelope, short tail mechanism" RELATED []
synonym: "viral short tail ejection system" EXACT [VZ:3954]
xref: VZ:3954 "Viral short tail ejection system"
is_a: GO:0039678 ! symbiont genome ejection through host cell envelope

[Term]
id: GO:0099003
name: vesicle-mediated transport in synapse
namespace: biological_process
def: "Any vesicle-mediated transport that occurs in a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0099004
name: obsolete calmodulin dependent kinase signaling pathway
namespace: biological_process
def: "OBSOLETE. Any signal transduction pathway involving calmodulin dependent kinase activity." [GOC:dos]
comment: This term was obsoleted because it does not represent a defined siagnling pathway.
synonym: "CAMK signaling pathway" EXACT []
is_obsolete: true
consider: GO:0061762

[Term]
id: GO:0099005
name: extrinsic component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane
relationship: part_of GO:0098944 ! postsynaptic recycling endosome membrane

[Term]
id: GO:0099006
name: symbiont entry into host cell via permeabilization of endosomal membrane
namespace: biological_process
def: "The entry of a symbiont into a host cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) of the symbiont. This process mediates the entry of some non-enveloped virus into eukaryotic cells. In some cases, viral membrane-penetration protein requires to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen." [PMID:15329727, PMID:25055856]
synonym: "viral entry via permeabilization of endosomal membrane" NARROW []
is_a: GO:0140267 ! symbiont entry into host cell via permeabilization of host membrane

[Term]
id: GO:0099007
name: extrinsic component of presynaptic endosome membrane
namespace: cellular_component
def: "The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0031313 ! extrinsic component of endosome membrane
relationship: part_of GO:0098954 ! presynaptic endosome membrane

[Term]
id: GO:0099008
name: symbiont entry into host cell via permeabilization of inner membrane
namespace: biological_process
def: "The entry of a symbiont into the cytoplasm of a host cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. This process mediates the entry of some non-enveloped viruses into prokaryotic cells. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization and permeabilization of the plasma membrane." [PMID:15795287, PMID:20427561]
synonym: "viral entry via permeabilization of inner membrane" NARROW []
is_a: GO:0140267 ! symbiont entry into host cell via permeabilization of host membrane

[Term]
id: GO:0099009
name: viral genome circularization
namespace: biological_process
def: "The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities." [PMID:11894948, PMID:15489417, PMID:19523475, PMID:319596, VZ:3968]
xref: VZ:3968 "Viral genome circularization"
is_a: GO:0016032 ! viral process

[Term]
id: GO:0099010
name: modification of postsynaptic structure
namespace: biological_process
def: "Any process that modifies the structure of a postsynapse." [GOC:dos]
comment: This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones.
subset: goslim_synapse
synonym: "synapse remodelling" BROAD []
is_a: GO:0099563 ! modification of synaptic structure

[Term]
id: GO:0099011
name: neuronal dense core vesicle exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208]
is_a: GO:1990504 ! dense core granule exocytosis

[Term]
id: GO:0099012
name: neuronal dense core vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos]
subset: goslim_synapse
is_a: GO:0032127 ! dense core granule membrane
relationship: part_of GO:0098992 ! neuronal dense core vesicle

[Term]
id: GO:0099013
name: neuronal dense core vesicle lumen
namespace: cellular_component
def: "The volume enclosed by a neuronal dense core vesicle membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098898 ! dense core granule lumen
relationship: part_of GO:0098992 ! neuronal dense core vesicle

[Term]
id: GO:0099014
name: neuronal dense core vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos]
is_a: GO:0061109 ! dense core granule organization

[Term]
id: GO:0099015
name: degradation of host chromosome by virus
namespace: biological_process
def: "The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis." [PMID:163355, PMID:335083, PMID:3972821, PMID:5263754, VZ:3947]
xref: VZ:3947
is_a: GO:0016032 ! viral process
relationship: part_of GO:0039693 ! viral DNA genome replication

[Term]
id: GO:0099016
name: symbiont-mediated evasion of DNA end degradation by host
namespace: biological_process
def: "A process by which a symbiont evades and ends degradation of its DNA when free DNA ends are exposed. DNA ends are exposed during the life cycle of some viruses and these are targeted by host cells to destroy the virus. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases." [GOC:dos, PMID:11894948, PMID:16949369, VZ:3963]
synonym: "DNA end degradation evasion by virus" EXACT []
synonym: "evasion by virus of DNA end degradation" RELATED []
synonym: "evasion of DNA end degradation by host" EXACT []
xref: VZ:3963
is_a: GO:0141177 ! symbiont-mediated evasion of recognition by host innate immune effector

[Term]
id: GO:0099017
name: maintenance of protein localization at cell tip
namespace: biological_process
def: "Any process in which localization of a protein is maintained at the cell tip." [GOC:dos, GOC:vw, PMID:12894167]
synonym: "maintenance of protein location at cell tip" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0099018
name: symbiont-mediated evasion of host restriction-modification system
namespace: biological_process
def: "A process by which a symbiont evades the DNA restriction modification system of its host. This process occurs in phages to protein themselves from bacterial restriction enzyme systems. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restriction enzymes while some use unusual bases in their genome to avoid restriction." [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966]
synonym: "evasion by virus of host restriction-modification system" RELATED []
synonym: "evasion of host restriction-modification system" EXACT []
synonym: "restriction-modification system evasion by virus" EXACT []
xref: VZ:3966
is_a: GO:0141177 ! symbiont-mediated evasion of recognition by host innate immune effector

[Term]
id: GO:0099019
name: maintenance of protein localization at growing cell tip
namespace: biological_process
def: "Any process in which localization of a protein is maintained at the growing cell tip." [GOC:dos, GOC:vw, PMID:24146635]
synonym: "maintenance of protein location at growing cell tip" EXACT []
is_a: GO:0099017 ! maintenance of protein localization at cell tip

[Term]
id: GO:0099020
name: perinuclear endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the perinuclear endoplasmic reticulum." [GOC:dos, GOC:vw]
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0097038 ! perinuclear endoplasmic reticulum

[Term]
id: GO:0099021
name: cortical endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the cortical endoplasmic reticulum." [GOC:dos, GOC:vw]
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0032541 ! cortical endoplasmic reticulum

[Term]
id: GO:0099022
name: vesicle tethering
namespace: biological_process
def: "The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion." [PMID:27243008]
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0006903 ! vesicle targeting

[Term]
id: GO:0099023
name: vesicle tethering complex
namespace: cellular_component
def: "Any protein complex that plays a role in vesicle tethering." [GOC:dos, GOC:vw, PMID:27243008]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0099024
name: plasma membrane invagination
namespace: biological_process
def: "An infolding of the plasma membrane." [GOC:dos, GOC:vw]
is_a: GO:0010324 ! membrane invagination

[Term]
id: GO:0099025
name: obsolete anchored component of postsynaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0045211

[Term]
id: GO:0099026
name: obsolete anchored component of presynaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "anchored component of presynaptic plasma membrane" EXACT []
is_obsolete: true
replaced_by: GO:0042734

[Term]
id: GO:0099027
name: obsolete anchored component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098835

[Term]
id: GO:0099028
name: obsolete anchored component of postynaptic endocytic zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098844

[Term]
id: GO:0099029
name: obsolete anchored component of presynaptic active zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0048787

[Term]
id: GO:0099030
name: obsolete anchored component of postsynaptic specialization membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0099634

[Term]
id: GO:0099031
name: obsolete anchored component of postsynaptic density membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098839

[Term]
id: GO:0099032
name: obsolete anchored component of postsynaptic early endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098896

[Term]
id: GO:0099033
name: obsolete anchored component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098944

[Term]
id: GO:0099034
name: obsolete anchored component of postsynaptic endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098895

[Term]
id: GO:0099035
name: obsolete anchored component of spine apparatus membrane
namespace: cellular_component
def: "OBSOLETE. The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098897

[Term]
id: GO:0099036
name: obsolete anchored component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0099012

[Term]
id: GO:0099037
name: obsolete anchored component of presynaptic endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098954

[Term]
id: GO:0099038
name: ceramide floppase activity
namespace: molecular_function
def: "Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [GOC:BHF, GOC:dos, GOC:rl]
synonym: "ATP-dependent ceramide transporter activity" BROAD []
synonym: "ATPase-coupled ceramide transporter activity" BROAD []
synonym: "ceramide floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
synonym: "ceramide-translocating ATPase activity" BROAD []
is_a: GO:0046623 ! sphingolipid floppase activity

[Term]
id: GO:0099039
name: sphingolipid translocation
namespace: biological_process
def: "The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:BHF, GOC:rl]
is_a: GO:0034204 ! lipid translocation
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0099040
name: ceramide translocation
namespace: biological_process
def: "The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:BHF, GOC:rl]
is_a: GO:0035627 ! ceramide transport
is_a: GO:0099039 ! sphingolipid translocation

[Term]
id: GO:0099041
name: vesicle tethering to Golgi
namespace: biological_process
def: "The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008]
is_a: GO:0099022 ! vesicle tethering

[Term]
id: GO:0099042
name: obsolete nucleation of clathrin-coated pit
namespace: biological_process
def: "OBSOLETE. The first step in clathrin-dependent endocytosis: invagination of the plasma membrane to form a pit." [GOC:dos, GOC:vw, PMID:21779028]
comment: The reason for obsoletion is this term is describing a process similar to that of clathrin coat assembly.
is_obsolete: true
replaced_by: GO:0048268

[Term]
id: GO:0099043
name: cargo loading involved in clathrin-dependent endocytosis
namespace: biological_process
def: "Formation of a macromolecular complex during clathrin-dependent endocytosis that connects the assembling clathrin coat to the proteins and/or lipoproteins to be transported in an endocytic vesicle. This complex includes a receptor and an adaptor protein that links the receptor to the clathrin coat." [GOC:dos, GOC:lb, GOC:vw, PMID:21779028]
is_a: GO:0035652 ! clathrin-coated vesicle cargo loading
relationship: part_of GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:0099044
name: vesicle tethering to endoplasmic reticulum
namespace: biological_process
def: "The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008]
is_a: GO:0099022 ! vesicle tethering

[Term]
id: GO:0099045
name: viral extrusion
namespace: biological_process
def: "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded." [PMID:15567492, VZ:3951]
xref: VZ:3951 "Viral extrusion"
is_a: GO:0046753 ! non-lytic viral release

[Term]
id: GO:0099046
name: clearance of foreign intracellular nucleic acids
namespace: biological_process
def: "A defense process that protects an organism from DNA or RNA from an invading organism." [GO:dos]
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0099047
name: clearance of foreign intracellular RNA
namespace: biological_process
def: "A defense process that protects an organism from invading foreign RNA." [GO:dos]
is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids

[Term]
id: GO:0099048
name: CRISPR-cas system
namespace: biological_process
def: "A defense response of that serves to clear host cells of foreign DNA and RNA. It has three distinct stage: acquisition of foreign DNA by integration into CRISPR loci in the host chromosome, CRISPR RNA (crRNA) biogenesis, and target interference. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, which describes the nature of the loci." [PMID:23495939, PMID:27302758, PMID:29440578]
is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids

[Term]
id: GO:0099049
name: clathrin coat assembly involved in endocytosis
namespace: biological_process
def: "The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation." [PMID:21779028]
is_a: GO:0048268 ! clathrin coat assembly
relationship: part_of GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:0099050
name: vesicle scission
namespace: biological_process
def: "The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane." [PMID:21779028]
is_a: GO:0090148 ! membrane fission

[Term]
id: GO:0099051
name: vesicle scission involved in endocytosis
namespace: biological_process
def: "The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane." [PMID:21779028]
is_a: GO:0099050 ! vesicle scission
relationship: part_of GO:0006897 ! endocytosis

[Term]
id: GO:0099052
name: vesicle scission involved in clathrin-mediated endocytosis
namespace: biological_process
def: "The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane." [PMID:21779028]
comment: Like other vesicle scission events this involves dynamin. At least some of the dynamin recruiting factors are distinct to scission of clathrin-coated vesicles (PMID:21779028).
is_a: GO:0099051 ! vesicle scission involved in endocytosis
relationship: part_of GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:0099053
name: obsolete activating signal cointegrator 1 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3." [PMID:12077347]
comment: The reason for obsoletion is that this term is equivalent to GO:0180022 RQC-trigger complex.
synonym: "ASC-1 complex" EXACT [PMID:12077347]
is_obsolete: true
replaced_by: GO:0180022

[Term]
id: GO:0099054
name: presynapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494]
subset: goslim_synapse
synonym: "presynapse biogenesis" EXACT [GOC:mah]
synonym: "presynaptic terminal assembly" EXACT [PMID:24449494]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0099172 ! presynapse organization
relationship: part_of GO:0007416 ! synapse assembly

[Term]
id: GO:0099055
name: obsolete integral component of postsynaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0045211

[Term]
id: GO:0099056
name: obsolete integral component of presynaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral component of presynaptic plasma membrane" EXACT []
is_obsolete: true
replaced_by: GO:0042734

[Term]
id: GO:0099057
name: obsolete integral component of presynaptic endocytic zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098835

[Term]
id: GO:0099058
name: obsolete integral component of postsynaptic endocytic zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098844

[Term]
id: GO:0099059
name: obsolete integral component of presynaptic active zone membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0048787

[Term]
id: GO:0099060
name: obsolete integral component of postsynaptic specialization membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0099634

[Term]
id: GO:0099061
name: obsolete integral component of postsynaptic density membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098839

[Term]
id: GO:0099062
name: obsolete integral component of postsynaptic early endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098896

[Term]
id: GO:0099063
name: obsolete integral component of postsynaptic recycling endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098944

[Term]
id: GO:0099064
name: obsolete integral component of postsynaptic endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098895

[Term]
id: GO:0099065
name: obsolete integral component of spine apparatus membrane
namespace: cellular_component
def: "OBSOLETE. The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098897

[Term]
id: GO:0099066
name: obsolete integral component of neuronal dense core vesicle membrane
namespace: cellular_component
def: "OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0099012

[Term]
id: GO:0099067
name: obsolete integral component of presynaptic endosome membrane
namespace: cellular_component
def: "OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098954

[Term]
id: GO:0099068
name: postsynapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL]
synonym: "postsynapse biogenesis" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0099173 ! postsynapse organization
relationship: part_of GO:0007416 ! synapse assembly

[Term]
id: GO:0099069
name: synaptic vesicle tethering involved in synaptic vesicle exocytosis
namespace: biological_process
def: "The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion." [GOC:rn]
is_a: GO:0090522 ! vesicle tethering involved in exocytosis
relationship: part_of GO:0016081 ! synaptic vesicle docking

[Term]
id: GO:0099070
name: static microtubule bundle
namespace: cellular_component
def: "A microtubule bundle that has a constant length, and in which microtubule sliding does not take place." [GOC:vw, PMID:26124291]
comment: In fission yeast, quiescent cells contain only static microtubule bundles.
synonym: "Q-MT bundle" NARROW []
synonym: "quiescent cell microtubule bundle" NARROW []
synonym: "quiescent cell MT bundle" NARROW []
is_a: GO:0097427 ! microtubule bundle

[Term]
id: GO:0099071
name: dynamic microtubule bundle
namespace: cellular_component
def: "A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place." [GOC:vw, PMID:26124291]
is_a: GO:0097427 ! microtubule bundle

[Term]
id: GO:0099072
name: regulation of postsynaptic membrane neurotransmitter receptor levels
namespace: biological_process
def: "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0099073
name: mitochondrion-derived vesicle
namespace: cellular_component
def: "A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790]
synonym: "MDV" EXACT [PMID:26618722]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0099074
name: mitochondrion to lysosome vesicle-mediated transport
namespace: biological_process
def: "Vesicle-mediated transport of cargo from the mitochondrion to the lysosome, mediated by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655]
synonym: "mitochondrion to lysosome transport" EXACT []
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport

[Term]
id: GO:0099075
name: mitochondrion-derived vesicle mediated transport
namespace: biological_process
def: "Vesicle-mediated transport of cargo from the mitochondrion by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655, PMID:37131163]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0099076
name: mitochondrion to peroxisome vesicle-mediated transport
namespace: biological_process
def: "Vesicle-mediated transport of cargo from the mitochondrion to the peroxisome, mediated by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655]
synonym: "mitochondrion to peroxisome transport" EXACT []
is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport

[Term]
id: GO:0099077
name: histone-dependent DNA binding
namespace: molecular_function
def: "DNA-binding activity that is dependent on binding to a histone." [PMID:11691835]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0099078
name: BORC complex
namespace: cellular_component
def: "A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0099079
name: actin body
namespace: cellular_component
def: "An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin." [PMID:16914523]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0099080
name: supramolecular complex
namespace: cellular_component
def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0099081
name: supramolecular polymer
namespace: cellular_component
def: "A polymeric supramolecular structure." [GOC:dos]
is_a: GO:0099080 ! supramolecular complex

[Term]
id: GO:0099082
name: retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide

[Term]
id: GO:0099083
name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission

[Term]
id: GO:0099084
name: postsynaptic specialization organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:BHF, GOC:sjp, PMID:21525273, PMID:26834556]
subset: goslim_synapse
synonym: "post synaptic specialization organization" EXACT []
synonym: "post-synaptic specialization organization" EXACT []
synonym: "postsynaptic specialization organisation" EXACT []
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0099173 ! postsynapse organization

[Term]
id: GO:0099085
name: DIF dechlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-." [PMID:1521542, PMID:22035794]
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity" EXACT []
synonym: "1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity" EXACT []
synonym: "DIF-1 3(5)-dechlorinase activity" EXACT []
synonym: "DIF-1 dechlorinase activity" EXACT []
synonym: "differentiation-inducing factor 1 dechlorinase activity" EXACT []
synonym: "differentiation-inducing factor dechlorinase activity" EXACT []
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0099086
name: synaptonemal structure
namespace: cellular_component
def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh, GOC:vw]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0099087
name: anterograde axonal transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse." [GOC:dos, PMID:26586091]
subset: goslim_synapse
synonym: "anterograde axonal transport of mRNA RNP complex" EXACT []
is_a: GO:0008089 ! anterograde axonal transport

[Term]
id: GO:0099088
name: axonal transport of messenger ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons." [GOC:dos, PMID:26586091]
subset: goslim_synapse
synonym: "axonal transport of mRNA RNP complex" EXACT []
is_a: GO:0098930 ! axonal transport

[Term]
id: GO:0099089
name: establishment of endoplasmic reticulum localization to postsynapse
namespace: biological_process
def: "The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine." [GOC:dos, PMID:21151132]
subset: goslim_synapse
synonym: "establishment of ER localization to postsynapse" EXACT [GOC:dos]
is_a: GO:0051686 ! establishment of ER localization

[Term]
id: GO:0099091
name: postsynaptic specialization, intracellular component
namespace: cellular_component
def: "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos]
subset: goslim_synapse
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0099572 ! postsynaptic specialization

[Term]
id: GO:0099092
name: postsynaptic density, intracellular component
namespace: cellular_component
def: "A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099091 ! postsynaptic specialization, intracellular component
relationship: part_of GO:0014069 ! postsynaptic density

[Term]
id: GO:0099093
name: calcium export from the mitochondrion
namespace: biological_process
def: "A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol." [GOC:dos, GOC:vw]
synonym: "calcium ion transmembrane export from mitochondrion" EXACT []
synonym: "mitochondrial calcium ion export" BROAD [GOC:vw]
synonym: "mitochondrial calcium release" EXACT []
is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0170037 ! export from the mitochondrion

[Term]
id: GO:0099094
name: ligand-gated monoatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ligand-gated cation channel activity" BROAD []
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0099095
name: ligand-gated monoatomic anion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ligand-gated anion channel activity" BROAD []
is_a: GO:0005253 ! monoatomic anion channel activity
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0099096
name: vestibular calyx terminal
namespace: cellular_component
def: "The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell." [PMID:10706428, PMID:25355208]
is_a: GO:0043679 ! axon terminus

[Term]
id: GO:0099098
name: microtubule polymerization based movement
namespace: biological_process
def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194]
is_a: GO:0007018 ! microtubule-based movement

[Term]
id: GO:0099099
name: G-protein gated monoatomic ion channel activity
namespace: molecular_function
def: "An ion channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos, PMID:35704701, Wikipedia:G_protein-gated_ion_channel]
synonym: "G-protein gated ion channel activity" BROAD []
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0099100
name: G-protein gated monoatomic cation channel activity
namespace: molecular_function
def: "A cation channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos]
synonym: "G-protein gated cation channel activity" BROAD []
is_a: GO:0099099 ! G-protein gated monoatomic ion channel activity

[Term]
id: GO:0099101
name: G-protein gated potassium channel activity
namespace: molecular_function
def: "A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos, PMID:9429760]
is_a: GO:0005267 ! potassium channel activity

[Term]
id: GO:0099102
name: G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential." [GOC:dos, PMID:9429760]
subset: goslim_synapse
is_a: GO:0099101 ! G-protein gated potassium channel activity

[Term]
id: GO:0099103
name: channel activator activity
namespace: molecular_function
def: "Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:dos]
synonym: "channel gating activity" EXACT []
is_a: GO:0016247 ! channel regulator activity
is_a: GO:0141109 ! transporter activator activity

[Term]
id: GO:0099104
name: potassium channel activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a potassium channel, resulting in its opening." [GOC:dos]
is_a: GO:0015459 ! potassium channel regulator activity
is_a: GO:0099103 ! channel activator activity

[Term]
id: GO:0099105
name: ion channel modulating, G protein-coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel." [GOC:dos]
synonym: "ion channel modulating, G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0099106
name: ion channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:dos]
is_a: GO:0016247 ! channel regulator activity

[Term]
id: GO:0099107
name: ion channel regulator activity involved in G protein-coupled receptor signaling pathway
namespace: molecular_function
def: "Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling." [GOC:dos]
synonym: "ion channel regulator activity involved in G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0099106 ! ion channel regulator activity

[Term]
id: GO:0099108
name: potassium channel activator activity involved in G protein-coupled receptor signaling pathway
namespace: molecular_function
def: "Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling." [PMID:9429760]
comment: Examples include G-protein beta-gamma complexes that bind to and activate potassium channels.
subset: goslim_synapse
synonym: "potassium channel activator activity involved in G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0099104 ! potassium channel activator activity
is_a: GO:0099107 ! ion channel regulator activity involved in G protein-coupled receptor signaling pathway

[Term]
id: GO:0099109
name: potassium channel activating, G protein-coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel." [GOC:dos, PMID:9429760]
synonym: "potassium channel activating, G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0099105 ! ion channel modulating, G protein-coupled receptor signaling pathway

[Term]
id: GO:0099110
name: microtubule polymerization based protein transport to cell tip cortex
namespace: biological_process
def: "The transport of a protein to the cortex of the cell tip, driven by polymerization of a microtubule to which the protein is attached." [GOC:dos, GOC:vw, PMID:11018050]
is_a: GO:0099112 ! microtubule polymerization based protein transport
is_a: GO:1990896 ! protein localization to cell cortex of cell tip

[Term]
id: GO:0099111
name: microtubule-based transport
namespace: biological_process
def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]
is_a: GO:0006810 ! transport

[Term]
id: GO:0099112
name: microtubule polymerization based protein transport
namespace: biological_process
def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0099118 ! microtubule-based protein transport

[Term]
id: GO:0099113
name: negative regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0051481 ! negative regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099115
name: chromosome, subtelomeric region
namespace: cellular_component
alt_id: GO:1990421
alt_id: GO:1990707
def: "A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin." [GOC:mah, PMID:18761674, PMID:22771823, PMID:26205977, PMID:7660126]
synonym: "nuclear subtelomeric heterochromatin" NARROW []
synonym: "sub-telomeric heterochromatin" RELATED []
synonym: "subtelomere" EXACT []
synonym: "subtelomeric heterochromatin" RELATED []
xref: SO:0001997
is_a: GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0099116
name: tRNA 5'-end processing
namespace: biological_process
def: "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:dos, GOC:pf, PMID:27484477]
synonym: "tRNA 5' processing" EXACT []
is_a: GO:0000966 ! RNA 5'-end processing
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0099117
name: protein transport along microtubule to cell tip
namespace: biological_process
def: "The movement of a protein along a microtubule to the cell-tip, mediated by motor proteins." [PMID:15177031]
is_a: GO:0098840 ! protein transport along microtubule
is_a: GO:1990151 ! protein localization to cell tip

[Term]
id: GO:0099118
name: microtubule-based protein transport
namespace: biological_process
def: "A microtubule-based process that results in the transport of proteins." [GOC:vw]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0015031 ! protein transport
is_a: GO:0099111 ! microtubule-based transport

[Term]
id: GO:0099119
name: obsolete 3-demethylubiquinol-8 3-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8." [GOC:ic]
comment: This term was obsoleted because it represents a specific substrate of 3-demethylubiquinol-n 3-O-methyltransferase activity ; GO:0061542.
is_obsolete: true
replaced_by: GO:0061542

[Term]
id: GO:0099120
name: socially cooperative development
namespace: biological_process
alt_id: GO:0090702
def: "The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies." [GOC:pf, PMID:12448714]
synonym: "colonial development" EXACT []
synonym: "non-reproductive fruiting body development" RELATED []
synonym: "socially co-operative development" EXACT []
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms

[Term]
id: GO:0099121
name: fungal sorus development
namespace: biological_process
def: "The process whose specific outcome is the progression of a fungal sorus over time, from its formation to the mature structure. A fungal sorus is a spore containing structure." [GOC:dos]
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0099122
name: RNA polymerase II C-terminal domain binding
namespace: molecular_function
def: "Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function." [PMID:20889714]
synonym: "RNAP II C-terminal binding" EXACT []
is_a: GO:0000993 ! RNA polymerase II complex binding

[Term]
id: GO:0099123
name: somato-dendritic dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron." [GOC:bf, GOC:PARL, PMID:21576241]
synonym: "somatodendritic dopamine release" EXACT [PMID:21576241]
synonym: "STD DA release" EXACT [PMID:21576241]
synonym: "STD dopamine release" EXACT [PMID:21576241]
is_a: GO:0014046 ! dopamine secretion
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0099124
name: axonal dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine from an axon." [GOC:bf, GOC:PARL, PMID:21576241]
synonym: "axonal DA release" EXACT [PMID:21576241]
synonym: "axonal dopamine release" EXACT [PMID:21576241]
is_a: GO:0014046 ! dopamine secretion
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0099125
name: PAK family kinase-Sog2 complex
namespace: cellular_component
def: "A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network." [PMID:23462181]
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:0099126
name: transforming growth factor beta complex
namespace: cellular_component
def: "A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP." [GOC:bhm, PMID:22943793]
synonym: "TGF-beta complex" EXACT []
synonym: "TGF-beta dimer" EXACT []
synonym: "TGFB complex" EXACT []
synonym: "TGFB dimer" EXACT []
synonym: "TGFbeta complex" EXACT []
synonym: "TGFbeta dimer" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0099127
name: obsolete envenomation resulting in positive regulation of argininosuccinate synthase activity in another organism
namespace: biological_process
def: "OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of the cytosolic argininosuccinate synthase in the bitten organism." [PMID:19491403]
comment: This term was obsoleted because it represents a molecular function.
synonym: "envenomation resulting in positive regulation of argininosuccinate synthase activity in other organism" EXACT []
is_obsolete: true

[Term]
id: GO:0099128
name: mitochondrial [2Fe-2S] assembly complex
namespace: cellular_component
def: "A protein complex capable of forming 2Fe-2S clusters in mitochondria. In humans it consists of ISCU, NFS1, LYRM4, NDUFAB1 and FXN." [PMID:31101807, PMID:34660592]
synonym: "mitochondrial iron-sulfur cluster assembly complex" RELATED []
synonym: "mitochondrial ISCU complex" EXACT []
is_a: GO:0098798 ! mitochondrial protein-containing complex
is_a: GO:1990221 ! L-cysteine desulfurase complex
is_a: GO:1990229 ! iron-sulfur cluster assembly complex

[Term]
id: GO:0099129
name: cochlear outer hair cell electromotile response
namespace: biological_process
def: "A rapid, force generating length change of an outer hair cell in response to electrical stimulation. This occurs naturally as during hearing where it serves a source of mechanical amplification." [PMID:12239568, PMID:16887876, PMID:2187727]
is_a: GO:0070252 ! actin-mediated cell contraction

[Term]
id: GO:0099130
name: estrogen binding
namespace: molecular_function
def: "Binding to an estrogen." [GOC:dos]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0099134
name: chimeric sorocarp development
namespace: biological_process
def: "Development of a sorocarp formed by aggregation of cells with different genotypes." [PMID:18272966]
subset: gocheck_do_not_annotate
is_a: GO:0030587 ! sorocarp development
is_a: GO:0099136 ! chimeric non-reproductive fruiting body development

[Term]
id: GO:0099135
name: chimeric colonial development
namespace: biological_process
def: "Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype." [PMID:18272966]
subset: gocheck_do_not_annotate
is_a: GO:0099120 ! socially cooperative development

[Term]
id: GO:0099136
name: chimeric non-reproductive fruiting body development
namespace: biological_process
def: "Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes." [PMID:18272966]
subset: gocheck_do_not_annotate
is_a: GO:0099135 ! chimeric colonial development

[Term]
id: GO:0099137
name: altruistic, chimeric, non-reproductive fruiting body development
namespace: biological_process
def: "Development of a chimeric, non-reproductive fruiting body in which cells of all genotypes have an equal chance of becoming a spore cell." [PMID:18272966]
synonym: "fully co-operative, chimeric, non-reproductive fruiting body development" EXACT []
is_a: GO:0099136 ! chimeric non-reproductive fruiting body development

[Term]
id: GO:0099138
name: altruistic, chimeric sorocarp development
namespace: biological_process
def: "Development of a chimeric sorocarp in which cells of all genotypes have an equal chance of becoming a spore cell." [PMID:18272966]
synonym: "fully co-operative, chimeric sorocarp development" EXACT []
is_a: GO:0099134 ! chimeric sorocarp development
is_a: GO:0099137 ! altruistic, chimeric, non-reproductive fruiting body development

[Term]
id: GO:0099139
name: cheating during chimeric sorocarp development
namespace: biological_process
def: "Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes." [PMID:18272966]
is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation
relationship: part_of GO:0099134 ! chimeric sorocarp development

[Term]
id: GO:0099140
name: presynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0099187 ! presynaptic cytoskeleton organization

[Term]
id: GO:0099141
name: cellular response to protozoan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:dos]
is_a: GO:0001562 ! response to protozoan

[Term]
id: GO:0099142
name: intracellularly ATP-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [PMID:9755289]
is_a: GO:0005217 ! intracellularly ligand-gated monoatomic ion channel activity
is_a: GO:0035381 ! ATP-gated ion channel activity

[Term]
id: GO:0099143
name: presynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015629 ! actin cytoskeleton
is_a: GO:0099569 ! presynaptic cytoskeleton

[Term]
id: GO:0099144
name: obsolete anchored component of synaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0097060

[Term]
id: GO:0099145
name: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:1902683 ! regulation of receptor localization to synapse
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:0098967 ! exocytic insertion of neurotransmitter receptor to postsynaptic membrane

[Term]
id: GO:0099146
name: obsolete intrinsic component of postsynaptic density membrane
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic specialization membrane" NARROW []
is_obsolete: true
replaced_by: GO:0098839

[Term]
id: GO:0099147
name: extrinsic component of postsynaptic density membrane
namespace: cellular_component
def: "The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
subset: goslim_synapse
is_a: GO:0098892 ! extrinsic component of postsynaptic specialization membrane
relationship: part_of GO:0098839 ! postsynaptic density membrane

[Term]
id: GO:0099148
name: regulation of synaptic vesicle docking
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle docking." [GOC:dos]
subset: goslim_synapse
is_a: GO:0106020 ! regulation of vesicle docking
relationship: regulates GO:0016081 ! synaptic vesicle docking

[Term]
id: GO:0099149
name: regulation of postsynaptic neurotransmitter receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse." [GOC:ai]
subset: goslim_synapse
synonym: "regulation of postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0065008 ! regulation of biological quality
relationship: regulates GO:0098884 ! postsynaptic neurotransmitter receptor internalization

[Term]
id: GO:0099150
name: regulation of postsynaptic specialization assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization." [GOC:dos]
subset: goslim_synapse
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0098698 ! postsynaptic specialization assembly

[Term]
id: GO:0099151
name: regulation of postsynaptic density assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099150 ! regulation of postsynaptic specialization assembly
is_a: GO:1904889 ! regulation of excitatory synapse assembly
is_a: GO:1905874 ! regulation of postsynaptic density organization
relationship: regulates GO:0097107 ! postsynaptic density assembly

[Term]
id: GO:0099152
name: regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos, PMID:20098723]
subset: goslim_synapse
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:1902473 ! regulation of protein localization to synapse
is_a: GO:1902683 ! regulation of receptor localization to synapse
is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport
relationship: regulates GO:0098887 ! neurotransmitter receptor transport, endosome to postsynaptic membrane

[Term]
id: GO:0099153
name: synaptic transmission, serotonergic
namespace: biological_process
def: "The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph]
synonym: "serotonergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099154
name: serotonergic synapse
namespace: cellular_component
def: "A synapse that uses serotonin as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0099155
name: synaptic transmission, noradrenergic
namespace: biological_process
def: "The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph]
synonym: "noradrenergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099156
name: cell-cell signaling via exosome
namespace: biological_process
def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038]
synonym: "exosome mediated" EXACT []
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0099157
name: trans-synaptic signaling via exosome
namespace: biological_process
def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038]
subset: goslim_synapse
synonym: "exosome mediated transynaptic signalling" EXACT []
synonym: "trans-synaptic signalling via exosome" EXACT []
is_a: GO:0099156 ! cell-cell signaling via exosome
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099158
name: regulation of recycling endosome localization within postsynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse." [GOC:dos, PMID:20098723]
subset: goslim_synapse
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:1903421 ! regulation of synaptic vesicle recycling
relationship: regulates GO:0036466 ! synaptic vesicle recycling via endosome

[Term]
id: GO:0099159
name: regulation of modification of postsynaptic structure
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic structure." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of postsynapse remodelling" EXACT []
is_a: GO:1905244 ! regulation of modification of synaptic structure
relationship: regulates GO:0099010 ! modification of postsynaptic structure

[Term]
id: GO:0099160
name: postsynaptic intermediate filament cytoskeleton
namespace: cellular_component
def: "The intermediate filament cytoskeleton that is part of a postsynapse." [GOC:dos, PMID:25869803]
subset: goslim_synapse
is_a: GO:0045111 ! intermediate filament cytoskeleton
is_a: GO:0099571 ! postsynaptic cytoskeleton

[Term]
id: GO:0099161
name: regulation of presynaptic dense core granule exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis." [GOC:dos, PMID:17881523]
subset: goslim_synapse
synonym: "regulation of presynaptic dense core vesicle exocytosis" EXACT syngo_official_label []
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter
is_a: GO:1905413 ! regulation of dense core granule exocytosis
relationship: regulates GO:0099525 ! presynaptic dense core vesicle exocytosis

[Term]
id: GO:0099162
name: regulation of neurotransmitter loading into synaptic vesicle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles." [GOC:dos, PMID:25176177]
subset: goslim_synapse
synonym: "regulation of neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342]
synonym: "regulation of synaptic vesicle neurotransmitter loading" EXACT syngo_official_label []
is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:0098693 ! regulation of synaptic vesicle cycle
relationship: regulates GO:0098700 ! neurotransmitter loading into synaptic vesicle

[Term]
id: GO:0099163
name: synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling to or from a synapse, mediated by nitric oxide." [GOC:dos, PMID:19038221]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099164
name: postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "The membrane component of the postsynaptic specialization of a symmetric synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099634 ! postsynaptic specialization membrane
relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse

[Term]
id: GO:0099165
name: postsynaptic specialization of symmetric synapse, intracellular component
namespace: cellular_component
def: "A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099091 ! postsynaptic specialization, intracellular component
relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse

[Term]
id: GO:0099166
name: obsolete intrinsic component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to postsynaptic specialization membrane of symmetric synapse" NARROW []
is_obsolete: true
replaced_by: GO:0099164

[Term]
id: GO:0099167
name: obsolete integral component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0099164

[Term]
id: GO:0099168
name: obsolete extrinsic component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
consider: GO:0099164

[Term]
id: GO:0099169
name: obsolete anchored component of postsynaptic specialization membrane of symmetric synapse
namespace: cellular_component
def: "OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0099164

[Term]
id: GO:0099170
name: postsynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission

[Term]
id: GO:0099171
name: presynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission

[Term]
id: GO:0099172
name: presynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "presynapse development" EXACT []
synonym: "presynapse morphogenesis" RELATED [GOC:BHF]
synonym: "presynapse organisation" EXACT []
synonym: "presynapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099173
name: postsynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynapse development" EXACT []
synonym: "postsynapse morphogenesis" RELATED [GOC:BHF]
synonym: "postsynapse organisation" EXACT []
synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099174
name: regulation of presynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of presynapse organisation" EXACT [GOC:mah]
synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of presynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099172 ! presynapse organization

[Term]
id: GO:0099175
name: regulation of postsynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of postsynapse organisation" EXACT [GOC:mah]
synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of postsynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099173 ! postsynapse organization

[Term]
id: GO:0099176
name: regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex." [GOC:dos, PMID:23209303]
subset: goslim_synapse
synonym: "regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0099177 ! regulation of trans-synaptic signaling
relationship: regulates GO:0098942 ! retrograde trans-synaptic signaling by trans-synaptic protein complex

[Term]
id: GO:0099177
name: regulation of trans-synaptic signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
relationship: regulates GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099178
name: regulation of retrograde trans-synaptic signaling by endocanabinoid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid." [GOC:dos, PMID:15664177]
synonym: "regulation of endocannabinoid-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0099177 ! regulation of trans-synaptic signaling
relationship: regulates GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid

[Term]
id: GO:0099179
name: regulation of synaptic membrane adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of synapse adhesion between pre- and post-synapse" EXACT syngo_official_label []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099560 ! synaptic membrane adhesion

[Term]
id: GO:0099180
name: zinc ion import into synaptic vesicle
namespace: biological_process
def: "The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle." [PMID:9990090]
subset: goslim_synapse
synonym: "zinc import into synaptic vesicle" EXACT []
synonym: "Zn2+ import into synaptic vesicle" EXACT []
is_a: GO:0062111 ! zinc ion import into organelle

[Term]
id: GO:0099181
name: structural constituent of presynapse
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a presynapse." [GOC:dos, PMID:23751498]
subset: goslim_synapse
is_a: GO:0098918 ! structural constituent of synapse

[Term]
id: GO:0099182
name: presynaptic intermediate filament cytoskeleton
namespace: cellular_component
def: "The intermediate filament cytoskeleton that is part of a presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045111 ! intermediate filament cytoskeleton
is_a: GO:0099569 ! presynaptic cytoskeleton

[Term]
id: GO:0099183
name: trans-synaptic signaling by BDNF, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099191 ! trans-synaptic signaling by BDNF
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099184
name: structural constituent of postsynaptic intermediate filament cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005200 ! structural constituent of cytoskeleton
is_a: GO:0099186 ! structural constituent of postsynapse

[Term]
id: GO:0099185
name: postsynaptic intermediate filament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045104 ! intermediate filament cytoskeleton organization
is_a: GO:0099188 ! postsynaptic cytoskeleton organization

[Term]
id: GO:0099186
name: structural constituent of postsynapse
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098918 ! structural constituent of synapse

[Term]
id: GO:0099187
name: presynaptic cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos]
is_a: GO:0007010 ! cytoskeleton organization
relationship: part_of GO:0099172 ! presynapse organization

[Term]
id: GO:0099188
name: postsynaptic cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007010 ! cytoskeleton organization
relationship: part_of GO:0099173 ! postsynapse organization

[Term]
id: GO:0099189
name: postsynaptic spectrin-associated cytoskeleton
namespace: cellular_component
def: "The portion of the spectrin-associated cytoskeleton contained within the postsynapse." [GOC:dos, PMID:28576936]
subset: goslim_synapse
is_a: GO:0014731 ! spectrin-associated cytoskeleton
is_a: GO:0099571 ! postsynaptic cytoskeleton

[Term]
id: GO:0099190
name: postsynaptic spectrin-associated cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse." [GOC:dos, PMID:28576936]
subset: goslim_synapse
is_a: GO:0099188 ! postsynaptic cytoskeleton organization

[Term]
id: GO:0099191
name: trans-synaptic signaling by BDNF
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
synonym: "trans-synaptic signaling by brain-derived neurotrophic factor" EXACT []
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099192
name: cerebellar Golgi cell to granule cell synapse
namespace: cellular_component
def: "A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell." [PMID:26134650]
subset: goslim_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0099240
name: obsolete intrinsic component of synaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic to synaptic membrane" NARROW []
is_obsolete: true
replaced_by: GO:0097060

[Term]
id: GO:0099243
name: extrinsic component of synaptic membrane
namespace: cellular_component
def: "The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
is_a: GO:0019897 ! extrinsic component of plasma membrane
relationship: part_of GO:0097060 ! synaptic membrane

[Term]
id: GO:0099400
name: caveola neck
namespace: cellular_component
def: "A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it." [GOC:pad, GOC:PARL, PMID:17227843]
is_a: GO:0098590 ! plasma membrane region
is_a: GO:0098857 ! membrane microdomain
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0099401
name: caveola bulb
namespace: cellular_component
def: "The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins." [GOC:PARL, GOC:POD, PMID:17227843]
synonym: "caveola crater" EXACT []
is_a: GO:0098857 ! membrane microdomain

[Term]
id: GO:0099402
name: plant organ development
namespace: biological_process
def: "Development of a plant organ, a multi-tissue plant structure that forms a functional unit." [GOC:dos]
synonym: "development of a plant organ" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048731 ! system development

[Term]
id: GO:0099403
name: maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the telomeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:rph, PMID:26373281]
synonym: "maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:mah]
synonym: "maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:mah]
synonym: "maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: part_of GO:0099404 ! mitotic sister chromatid cohesion, telomeric

[Term]
id: GO:0099404
name: mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "The cell cycle process in which telomeres of sister chromatids are joined during mitosis." [GOC:BHF, GOC:BHF_telomere, GOC:mah, GOC:rph, PMID:26373281]
synonym: "mitotic sister chromatid cohesion at telomere" EXACT [GOC:mah]
synonym: "sister chromatid cohesion at telomere at mitosis" EXACT [GOC:mah]
synonym: "telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
is_a: GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0099500
name: vesicle fusion to plasma membrane
namespace: biological_process
def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0140029 ! exocytic process

[Term]
id: GO:0099501
name: exocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an exocytic vesicle." [GOC:dos]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030658 ! transport vesicle membrane
relationship: part_of GO:0070382 ! exocytic vesicle

[Term]
id: GO:0099502
name: calcium-dependent activation of synaptic vesicle fusion
namespace: biological_process
def: "The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane." [PMID:23060190]
subset: goslim_synapse
is_a: GO:0031632 ! positive regulation of synaptic vesicle fusion to presynaptic active zone membrane
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0099503
name: secretory vesicle
namespace: cellular_component
def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]
subset: goslim_drosophila
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0099504
name: synaptic vesicle cycle
namespace: biological_process
def: "A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [GOC:aruk, GOC:bc, PMID:15217342]
subset: goslim_synapse
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse

[Term]
id: GO:0099505
name: regulation of presynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the potential difference across a presynaptic membrane." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "regulation of pre-synaptic membrane potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0099506
name: synaptic vesicle transport along actin filament
namespace: biological_process
def: "The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030050 ! vesicle transport along actin filament
is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport

[Term]
id: GO:0099507
name: ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:15145529, PMID:19558451]
subset: goslim_synapse
synonym: "ligand gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ligand-gated ion channel activity involved in regulation of presynaptic membrane potential" BROAD []
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0099508
name: voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse." [GOC:dos]
subset: goslim_synapse
synonym: "voltage gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "voltage-gated ion channel activity involved in regulation of presynaptic membrane potential" BROAD []
is_a: GO:0005244 ! voltage-gated monoatomic ion channel activity

[Term]
id: GO:0099509
name: regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that regulates the concentration of calcium in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration
is_a: GO:0070050 ! neuron cellular homeostasis

[Term]
id: GO:0099510
name: calcium ion binding involved in regulation of cytosolic calcium ion concentration
namespace: molecular_function
def: "The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
synonym: "regulation of cytosolic calcium ion concentration by calcium ion buffering" EXACT []
is_a: GO:0005509 ! calcium ion binding

[Term]
id: GO:0099511
name: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
namespace: molecular_function
def: "Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0099512
name: supramolecular fiber
namespace: cellular_component
alt_id: GO:0043205
def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]
synonym: "fibril" RELATED []
is_a: GO:0099081 ! supramolecular polymer

[Term]
id: GO:0099513
name: polymeric cytoskeletal fiber
namespace: cellular_component
def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0099514
name: synaptic vesicle cytoskeletal transport
namespace: biological_process
def: "The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0048489 ! synaptic vesicle transport
is_a: GO:0099518 ! vesicle cytoskeletal trafficking

[Term]
id: GO:0099515
name: actin filament-based transport
namespace: biological_process
def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport

[Term]
id: GO:0099517
name: synaptic vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport

[Term]
id: GO:0099518
name: vesicle cytoskeletal trafficking
namespace: biological_process
def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]
synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl]
synonym: "vesicle cytoskeletal transport" EXACT []
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:0099519
name: dense core granule cytoskeletal transport
namespace: biological_process
def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451]
synonym: "dense core vesicle cytoskeletal trafficking" EXACT []
is_a: GO:0099518 ! vesicle cytoskeletal trafficking
is_a: GO:1901950 ! dense core granule transport

[Term]
id: GO:0099520
name: monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos]
subset: goslim_synapse
synonym: "ion antiporter activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ion antiporter activity involved in regulation of presynaptic membrane potential" EXACT []
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0099521
name: ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:17220883]
subset: goslim_synapse
synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential" EXACT []
is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity

[Term]
id: GO:0099522
name: cytosolic region
namespace: cellular_component
def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos]
subset: gocheck_do_not_annotate
synonym: "region of cytosol" EXACT []
is_a: GO:0005829 ! cytosol

[Term]
id: GO:0099523
name: presynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099522 ! cytosolic region
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0099524
name: postsynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099522 ! cytosolic region
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099525
name: presynaptic dense core vesicle exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208]
subset: goslim_synapse
is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter
is_a: GO:0099011 ! neuronal dense core vesicle exocytosis

[Term]
id: GO:0099526
name: presynapse to nucleus signaling pathway
namespace: biological_process
def: "The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077]
comment: This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term.
subset: goslim_synapse
synonym: "presynaptic signaling to nucleus" EXACT []
is_a: GO:0098928 ! presynaptic signal transduction

[Term]
id: GO:0099527
name: postsynapse to nucleus signaling pathway
namespace: biological_process
def: "The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077]
subset: goslim_synapse
synonym: "postsynaptic signaling to nucleus" EXACT []
is_a: GO:0098926 ! postsynaptic signal transduction

[Term]
id: GO:0099528
name: G protein-coupled neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]
synonym: "G-protein coupled neurotransmitter receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0099529
name: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel)." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity

[Term]
id: GO:0099530
name: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
synonym: "G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0099531
name: presynaptic process involved in chemical synaptic transmission
namespace: biological_process
def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos]
subset: gocheck_obsoletion_candidate
subset: goslim_synapse
is_a: GO:0050877 ! nervous system process
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099532
name: synaptic vesicle endosomal processing
namespace: biological_process
def: "The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:aruk, GOC:bc, GOC:dos]
comment: This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.
subset: goslim_synapse
synonym: "synaptic vesicle processing via endosome" EXACT []
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0099533
name: positive regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099534
name: calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
subset: goslim_synapse
synonym: "calcium ion binding involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "presynaptic calcium ion buffering" EXACT []
synonym: "regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering" EXACT []
is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099535
name: synapse-associated extracellular matrix
namespace: cellular_component
def: "The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:dos]
subset: goslim_synapse
synonym: "extra-synaptic extracellular matrix" EXACT []
is_a: GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0099536
name: synaptic signaling
namespace: biological_process
def: "Cell-cell signaling to, from or within a synapse." [GOC:dos]
subset: goslim_drosophila
subset: goslim_synapse
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0099537
name: trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099538
name: synaptic signaling via neuropeptide
namespace: biological_process
def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099539
name: neuropeptide secretion from presynapse
namespace: biological_process
def: "The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration." [PMID:17553987, PMID:24653208]
subset: goslim_synapse
synonym: "neuropeptide secretion from presynapse via dense core granule exocytosis" EXACT []
is_a: GO:0002790 ! peptide secretion
is_a: GO:0099525 ! presynaptic dense core vesicle exocytosis
relationship: part_of GO:0099538 ! synaptic signaling via neuropeptide

[Term]
id: GO:0099540
name: trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling
is_a: GO:0099538 ! synaptic signaling via neuropeptide

[Term]
id: GO:0099541
name: trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099542
name: trans-synaptic signaling by endocannabinoid
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid

[Term]
id: GO:0099543
name: trans-synaptic signaling by soluble gas
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099544
name: perisynaptic space
namespace: cellular_component
def: "The extracellular region immediately adjacent to to a synapse." [GOC:dos]
subset: goslim_synapse
synonym: "extrasynaptic space" EXACT syngo_official_label []
is_a: GO:0005576 ! extracellular region

[Term]
id: GO:0099545
name: trans-synaptic signaling by trans-synaptic complex
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099546
name: protein catabolic process, modulating synaptic transmission
namespace: biological_process
def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
relationship: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099547
name: regulation of translation at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140243 ! regulation of translation at synapse

[Term]
id: GO:0099548
name: trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099163 ! synaptic signaling by nitric oxide
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0099549
name: trans-synaptic signaling by carbon monoxide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0099550
name: trans-synaptic signaling, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099551
name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099552
name: trans-synaptic signaling by lipid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099553
name: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid
is_a: GO:0099552 ! trans-synaptic signaling by lipid, modulating synaptic transmission

[Term]
id: GO:0099554
name: trans-synaptic signaling by soluble gas, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099555
name: trans-synaptic signaling by nitric oxide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide
is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission

[Term]
id: GO:0099556
name: trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099549 ! trans-synaptic signaling by carbon monoxide
is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission

[Term]
id: GO:0099557
name: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:19029886]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission

[Term]
id: GO:0099558
name: maintenance of synapse structure
namespace: biological_process
def: "A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds." [GOC:dos, PMID:24449494, PMID:25611509]
subset: goslim_synapse
synonym: "synaptic maintenance" EXACT []
is_a: GO:0034331 ! cell junction maintenance
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0099559
name: maintenance of alignment of postsynaptic density and presynaptic active zone
namespace: biological_process
def: "The process by which alignment between postsynaptic density and presynaptic active zone is maintained." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099558 ! maintenance of synapse structure

[Term]
id: GO:0099560
name: synaptic membrane adhesion
namespace: biological_process
def: "The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]
subset: goslim_synapse
synonym: "synapse adhesion between pre- and post-synapse" EXACT syngo_official_label []
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099561
name: synaptic membrane adhesion to extracellular matrix
namespace: biological_process
def: "The binding of a synaptic membrane to the extracellular matrix via adhesion molecules." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099562
name: maintenance of postsynaptic density structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins in the presynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098880 ! maintenance of postsynaptic specialization structure

[Term]
id: GO:0099563
name: modification of synaptic structure
namespace: biological_process
def: "Any process that modifies the structure/morphology of a synapse." [GOC:dos]
comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
subset: goslim_synapse
synonym: "synapse remodelling" EXACT []
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0099564
name: modification of synaptic structure, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission via modification of the structure of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099563 ! modification of synaptic structure
relationship: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099565
name: chemical synaptic transmission, postsynaptic
namespace: biological_process
def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic process involved in chemical synaptic transmission" EXACT syngo_official_label []
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0050877 ! nervous system process
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099566
name: regulation of postsynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that regulates the concentration of calcium in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099567
name: calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
subset: goslim_synapse
synonym: "calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "postsynaptic calcium ion buffering" EXACT []
synonym: "regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering" RELATED []
is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099568
name: cytoplasmic region
namespace: cellular_component
def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos]
subset: gocheck_do_not_annotate
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0099569
name: presynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0099571
name: postsynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099572
name: postsynaptic specialization
namespace: cellular_component
def: "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028]
subset: goslim_synapse
is_a: GO:0043226 ! organelle
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099573
name: glutamatergic postsynaptic density
namespace: cellular_component
def: "The post-synaptic specialization of a glutamatergic excitatory synapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic specialization, glutamatergic neuron-to-neuron synapse" EXACT syngo_official_label []
is_a: GO:0014069 ! postsynaptic density

[Term]
id: GO:0099574
name: regulation of protein catabolic process at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140250 ! regulation protein catabolic process at synapse

[Term]
id: GO:0099575
name: regulation of protein catabolic process at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission

[Term]
id: GO:0099576
name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission

[Term]
id: GO:0099577
name: regulation of translation at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140244 ! regulation of translation at presynapse

[Term]
id: GO:0099578
name: regulation of translation at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140245 ! regulation of translation at postsynapse

[Term]
id: GO:0099579
name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential." [GOC:dos]
subset: goslim_synapse
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" EXACT []
is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
is_a: GO:0099530 ! G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

[Term]
id: GO:0099580
name: monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential." [GOC:dos]
subset: goslim_synapse
synonym: "ion antiporter activity involved in regulation of post-synaptic membrane potential" EXACT []
synonym: "ion antiporter activity involved in regulation of postsynaptic membrane potential" EXACT []
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0099581
name: ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential." [GOC:dos]
subset: goslim_synapse
synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential" EXACT []
synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential" EXACT []
is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity

[Term]
id: GO:0099582
name: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0099583
name: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
synonym: "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity

[Term]
id: GO:0099585
name: release of sequestered calcium ion into presynaptic cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0099586
name: release of sequestered calcium ion into postsynaptic cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0099587
name: inorganic ion import across plasma membrane
namespace: biological_process
def: "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "inorganic ion import into cell" EXACT []
is_a: GO:0098660 ! inorganic ion transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0099588
name: positive regulation of postsynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099589
name: serotonin receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:dos]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0099590
name: neurotransmitter receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor." [GOC:dos]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0031623 ! receptor internalization

[Term]
id: GO:0099592
name: endocytosed synaptic vesicle processing via endosome
namespace: biological_process
def: "The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:dos]
synonym: "synaptic vesicle processing via endosome involved in synaptic vesicle recycling" EXACT []
is_a: GO:0099003 ! vesicle-mediated transport in synapse
is_a: GO:0099532 ! synaptic vesicle endosomal processing
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome

[Term]
id: GO:0099593
name: endocytosed synaptic vesicle to endosome fusion
namespace: biological_process
def: "Fusion of an endocytosed synaptic vesicle with an endosome." [GOC:dos]
is_a: GO:0016189 ! synaptic vesicle to endosome fusion
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome

[Term]
id: GO:0099601
name: regulation of neurotransmitter receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos]
subset: gocheck_obsoletion_candidate
subset: goslim_synapse
is_a: GO:0010469 ! regulation of signaling receptor activity

[Term]
id: GO:0099602
name: neurotransmitter receptor regulator activity
namespace: molecular_function
def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:18387948]
is_a: GO:0030545 ! signaling receptor regulator activity

[Term]
id: GO:0099604
name: ligand-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos]
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0099605
name: regulation of action potential firing rate
namespace: biological_process
def: "Any process that regulates the frequency of action potentials in a spike train." [ISBN:978-0071390118]
is_a: GO:0098900 ! regulation of action potential

[Term]
id: GO:0099606
name: microtubule plus-end directed mitotic chromosome migration
namespace: biological_process
def: "The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression." [GOC:dos, PMID:26258632, PMID:26705896]
synonym: "plus-end directed chromosome gliding" EXACT [PMID:26258632]
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0051303 ! establishment of chromosome localization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007080 ! mitotic metaphase chromosome alignment

[Term]
id: GO:0099607
name: lateral attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "The cellular process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate)." [PMID:26258632, PMID:26705896]
is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:0099608
name: regulation of action potential firing pattern
namespace: biological_process
def: "Any process that regulates the temporal pattern of a sequence of action potentials in a neuron." [ISBN:978-0071390118]
synonym: "spike train sculpting" EXACT []
is_a: GO:0098900 ! regulation of action potential
relationship: regulates GO:0098874 ! spike train

[Term]
id: GO:0099609
name: microtubule lateral binding
namespace: molecular_function
def: "Binding to the side of a microtubule." [GOC:dos]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0099610
name: action potential initiation
namespace: biological_process
def: "The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate." [ISBN:978-0071390118, PMID:19439602]
synonym: "action potential firing" EXACT []
synonym: "action potential triggering" EXACT []
is_a: GO:0001508 ! action potential

[Term]
id: GO:0099611
name: regulation of action potential firing threshold
namespace: biological_process
def: "Any process that regulates the potential at which an axon potential is triggered." [ISBN:978-0071390118]
is_a: GO:0098900 ! regulation of action potential

[Term]
id: GO:0099612
name: protein localization to axon
namespace: biological_process
def: "A process in which a protein is transported to or maintained in a location within an axon." [GOC:dos, PMID:26157139]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0099613
name: protein localization to cell wall
namespace: biological_process
def: "The process of directing proteins towards the cell-wall." [ISBN:0716731363]
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0099614
name: protein localization to spore cell wall
namespace: biological_process
def: "A process in which a protein is transported, tethered to or otherwise maintained in a spore cell wall." [GOC:dos]
synonym: "protein targeting to spore cell wall" RELATED []
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0099615
name: (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor." [PMID:26774271]
synonym: "D-2HG-pyruvate transhydrogenase activity" EXACT []
synonym: "R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity" EXACT []
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0099616
name: extrinsic component of matrix side of mitochondrial inner membrane
namespace: cellular_component
def: "The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
is_a: GO:0031314 ! extrinsic component of mitochondrial inner membrane
relationship: part_of GO:0099617 ! matrix side of mitochondrial inner membrane

[Term]
id: GO:0099617
name: matrix side of mitochondrial inner membrane
namespace: cellular_component
def: "The side (leaflet) of the mitochondrial inner membrane that faces the matrix." [GOC:dos]
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0099618
name: UDP-glucuronic acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+." [GOC:al, GOC:dos]
synonym: "UDP-GlcUA decarboxylase activity" EXACT []
xref: EC:1.1.1.305
xref: RHEA:24702
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0099619
name: UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [PMID:15695810, PMID:15807526, PMID:15809294, PMID:15939024, PMID:17928292]
synonym: "10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity" EXACT []
synonym: "ArnAFT activity" EXACT []
synonym: "UDP-L-Ara4N formyltransferase activity" EXACT []
xref: EC:2.1.2.13
xref: RHEA:24706
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0099620
name: UDP-4-amino-4-deoxy-L-arabinose aminotransferase
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate." [GOC:al, GOC:dos, PMID:12429098, PMID:12704196]
synonym: "UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase" EXACT []
synonym: "UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase" EXACT []
synonym: "UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase" EXACT []
synonym: "UDP-Ara4O aminotransferase" EXACT []
synonym: "UDP-L-Ara4N transaminase" EXACT []
xref: EC:2.6.1.87
xref: RHEA:24710
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0099621
name: undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity
namespace: molecular_function
alt_id: GO:0103019
def: "Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate." [GOC:al, GOC:dos, PMID:11706007, PMID:15695810]
synonym: "Ara4FN transferase activity" EXACT []
synonym: "undecaprenyl phosphate-L-Ara4FN transferase activity" EXACT []
synonym: "undecaprenyl-phosphate Ara4FN transferase activity" EXACT []
xref: EC:2.4.2.53
xref: MetaCyc:RXN0-3521
xref: RHEA:27722
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0099622
name: cardiac muscle cell membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF]
is_a: GO:0086009 ! membrane repolarization

[Term]
id: GO:0099623
name: regulation of cardiac muscle cell membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte." [GOC:BHF, GOC:dos, GOC:rl]
synonym: "heart repolarization" RELATED []
synonym: "regulation of cardiac muscle cell repolarization" EXACT []
synonym: "regulation of cardiomyocyte membrane repolarization" EXACT []
is_a: GO:0060306 ! regulation of membrane repolarization
relationship: regulates GO:0099622 ! cardiac muscle cell membrane repolarization

[Term]
id: GO:0099624
name: atrial cardiac muscle cell membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF]
is_a: GO:0099622 ! cardiac muscle cell membrane repolarization

[Term]
id: GO:0099625
name: ventricular cardiac muscle cell membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0099622 ! cardiac muscle cell membrane repolarization

[Term]
id: GO:0099626
name: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels." [GOC:dos, PMID:15548655]
subset: goslim_synapse
synonym: "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

[Term]
id: GO:0099627
name: neurotransmitter receptor cycle
namespace: biological_process
def: "The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping)." [GOC:dos]
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0099628
name: neurotransmitter receptor diffusion trapping
namespace: biological_process
def: "The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane." [PMID:18832033]
subset: goslim_synapse
is_a: GO:0098953 ! receptor diffusion trapping

[Term]
id: GO:0099629
name: postsynaptic specialization of symmetric synapse
namespace: cellular_component
def: "A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses." [PMID:18832033]
subset: goslim_synapse
synonym: "postsynaptic density of inhibitory synapse" EXACT [PMID:18832033]
is_a: GO:0099572 ! postsynaptic specialization
relationship: part_of GO:0032280 ! symmetric synapse

[Term]
id: GO:0099630
name: postsynaptic neurotransmitter receptor cycle
namespace: biological_process
def: "The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane." [PMID:18832033]
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099627 ! neurotransmitter receptor cycle

[Term]
id: GO:0099631
name: postsynaptic endocytic zone cytoplasmic component
namespace: cellular_component
def: "The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0098843 ! postsynaptic endocytic zone

[Term]
id: GO:0099632
name: protein transport within plasma membrane
namespace: biological_process
def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos]
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0099633
name: protein localization to postsynaptic specialization membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density)." [GOC:dos]
synonym: "protein localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie]
is_a: GO:0033365 ! protein localization to organelle
is_a: GO:1903539 ! protein localization to postsynaptic membrane

[Term]
id: GO:0099634
name: postsynaptic specialization membrane
namespace: cellular_component
def: "The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0099572 ! postsynaptic specialization

[Term]
id: GO:0099635
name: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission." [GOC:dos]
subset: goslim_synapse
xref: Reactome:R-HSA-9659515 "CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell"
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0099636
name: cytoplasmic streaming
namespace: biological_process
def: "The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains." [GOC:dos, Wikipedia:Cytoplasmic_streaming&oldid=706214009]
xref: Wikipedia:Cytoplasmic_streaming
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0099637
name: neurotransmitter receptor transport
namespace: biological_process
def: "The directed movement of neurotransmitter receptors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015031 ! protein transport
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0099638
name: endosome to plasma membrane protein transport
namespace: biological_process
def: "The directed movement of proteins from the endosome to the plasma membrane in transport vesicles." [GOC:dos]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0032456 ! endocytic recycling
is_a: GO:0061951 ! establishment of protein localization to plasma membrane

[Term]
id: GO:0099639
name: neurotransmitter receptor transport, endosome to plasma membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane
is_a: GO:0099638 ! endosome to plasma membrane protein transport

[Term]
id: GO:0099640
name: axo-dendritic protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axonal protein transport" NARROW []
is_a: GO:0008088 ! axo-dendritic transport
is_a: GO:0098840 ! protein transport along microtubule

[Term]
id: GO:0099641
name: anterograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" BROAD []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport
is_a: GO:1905383 ! protein localization to presynapse

[Term]
id: GO:0099642
name: retrograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" BROAD []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:0099643
name: signal release from synapse
namespace: biological_process
def: "Any signal release from a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0023061 ! signal release
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0099644
name: protein localization to presynaptic membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a presynaptic membrane." [GOC:dos]
synonym: "protein localisation in presynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to presynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in presynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1905383 ! protein localization to presynapse
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0099645
name: neurotransmitter receptor localization to postsynaptic specialization membrane
namespace: biological_process
def: "A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density)." [GOC:dos]
subset: goslim_synapse
synonym: "neurotransmitter receptor localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie]
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
is_a: GO:0099633 ! protein localization to postsynaptic specialization membrane

[Term]
id: GO:0099646
name: neurotransmitter receptor transport, plasma membrane to endosome
namespace: biological_process
def: "Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome." [GOC:dos]
subset: goslim_synapse
is_a: GO:0036010 ! protein localization to endosome
is_a: GO:0048227 ! plasma membrane to endosome transport
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0099699
name: obsolete integral component of synaptic membrane
namespace: cellular_component
def: "OBSOLETE. The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0097060

[Term]
id: GO:0099703
name: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission." [GOC:dos, ISBN:9780071120005]
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099738
name: cell cortex region
namespace: cellular_component
def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos]
subset: gocheck_do_not_annotate
synonym: "perimembrane region" EXACT []
is_a: GO:0005938 ! cell cortex
is_a: GO:0099568 ! cytoplasmic region

[Term]
id: GO:0100001
name: regulation of skeletal muscle contraction by action potential
namespace: biological_process
def: "Any action potential process that regulates skeletal muscle contraction." [GOC:cjm, GOC:obol]
is_a: GO:0001508 ! action potential
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0100002
name: obsolete negative regulation of protein kinase activity by protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Any protein phosphorylation process that negatively regulates protein kinase activity." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0004860

[Term]
id: GO:0100003
name: obsolete positive regulation of sodium ion transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sodium ion transport." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100004
name: obsolete positive regulation of peroxisome organization by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates peroxisome organization." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100005
name: obsolete positive regulation of ethanol catabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates ethanol catabolic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100006
name: obsolete positive regulation of sulfite transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sulfite transport." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100007
name: obsolete negative regulation of ceramide biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates ceramide biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100008
name: regulation of fever generation by prostaglandin biosynthetic process
namespace: biological_process
def: "Any prostaglandin biosynthetic process process that regulates fever generation." [GOC:cjm, GOC:obol]
is_a: GO:0001516 ! prostaglandin biosynthetic process
relationship: regulates GO:0001660 ! fever generation

[Term]
id: GO:0100009
name: regulation of fever generation by prostaglandin secretion
namespace: biological_process
def: "Any prostaglandin secretion process that regulates fever generation." [GOC:cjm, GOC:obol]
is_a: GO:0032310 ! prostaglandin secretion
relationship: regulates GO:0001660 ! fever generation

[Term]
id: GO:0100010
name: positive regulation of fever generation by prostaglandin biosynthetic process
namespace: biological_process
def: "Any prostaglandin biosynthetic process process that positively_regulates fever generation." [GOC:cjm, GOC:obol]
is_a: GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process
relationship: positively_regulates GO:0001660 ! fever generation

[Term]
id: GO:0100011
name: positive regulation of fever generation by prostaglandin secretion
namespace: biological_process
def: "Any prostaglandin secretion process that positively_regulates fever generation." [GOC:cjm, GOC:obol]
is_a: GO:0100009 ! regulation of fever generation by prostaglandin secretion
relationship: positively_regulates GO:0001660 ! fever generation

[Term]
id: GO:0100012
name: obsolete regulation of heart induction by canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. Any canonical Wnt signaling pathway process that regulates heart induction." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0060070
consider: GO:0090381

[Term]
id: GO:0100013
name: obsolete positive regulation of fatty acid beta-oxidation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates fatty acid beta-oxidation." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100014
name: obsolete positive regulation of mating type switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates mating type switching." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100015
name: obsolete positive regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates inositol biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100016
name: obsolete regulation of thiamine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates thiamine biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100017
name: obsolete negative regulation of cell-cell adhesion by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates single organismal cell-cell adhesion." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100018
name: obsolete regulation of glucose import by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates glucose import." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100019
name: obsolete regulation of cAMP-mediated signaling by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cAMP-mediated signaling." [GOC:cjm, GOC:obol]
comment: The reason for obsoletion is that cAMP-mediated signaling is not mediated by transcription from RNA polII promoter.
is_obsolete: true

[Term]
id: GO:0100020
name: obsolete regulation of transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates transport." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100021
name: obsolete regulation of iron ion transport by transcription from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0100022
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates iron ion transport." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of iron ion import by transcription from RNA polymerase II promoter" RELATED []
is_obsolete: true

[Term]
id: GO:0100023
name: obsolete regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates meiotic nuclear division." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100024
name: obsolete regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates carbohydrate metabolic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100025
name: obsolete negative regulation of cellular amino acid biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular amino acid biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100026
name: obsolete positive regulation of DNA repair by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates DNA repair." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:0006281

[Term]
id: GO:0100027
name: obsolete regulation of cell separation after cytokinesis by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cell separation after cytokinesis." [GOC:cjm, GOC:obol]
is_obsolete: true

[Term]
id: GO:0100028
name: obsolete regulation of conjugation with cellular fusion by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates conjugation with cellular fusion." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100029
name: obsolete regulation of histone modification by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone modification." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it describes a process that does not exist.
is_obsolete: true

[Term]
id: GO:0100030
name: obsolete regulation of histone acetylation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone acetylation." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it describes a process that does not exist.
is_obsolete: true

[Term]
id: GO:0100031
name: obsolete regulation of histone methylation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone methylation." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it describes a process that does not exist.
is_obsolete: true

[Term]
id: GO:0100032
name: obsolete positive regulation of phospholipid biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phospholipid biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100033
name: obsolete regulation of fungal-type cell wall biogenesis by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates fungal-type cell wall biogenesis." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100034
name: obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates 4,6-pyruvylated galactose residue biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100035
name: obsolete negative regulation of transmembrane transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates transmembrane transport." [GOC:cjm, GOC:obol]
comment: The term was obsoleted because it is better represented by a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100036
name: obsolete positive regulation of purine nucleotide biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates purine nucleotide biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100037
name: obsolete positive regulation of cellular alcohol catabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates cellular alcohol catabolic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100038
name: obsolete regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cellular response to oxidative stress." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100039
name: obsolete regulation of pyrimidine nucleotide biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates pyrimidine nucleotide biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100040
name: obsolete negative regulation of invasive growth in response to glucose limitation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates invasive growth in response to glucose limitation." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100041
name: obsolete positive regulation of pseudohyphal growth by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates pseudohyphal growth." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100042
name: obsolete negative regulation of pseudohyphal growth by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates pseudohyphal growth." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100043
name: obsolete negative regulation of cellular response to alkaline pH by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular response to alkaline pH." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100044
name: obsolete negative regulation of cellular hyperosmotic salinity response by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular hyperosmotic salinity response." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100045
name: obsolete negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates arginine catabolic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:1900082

[Term]
id: GO:0100046
name: obsolete positive regulation of arginine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates arginine biosynthetic process." [GOC:cjm, GOC:obol]
comment: GO:0100046
is_obsolete: true

[Term]
id: GO:0100047
name: obsolete negative regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates inositol biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100048
name: obsolete positive regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phosphatidylcholine biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100049
name: obsolete negative regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phosphatidylcholine biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100050
name: obsolete negative regulation of mating type switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates mating type switching." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100051
name: obsolete positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates meiotic nuclear division." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100052
name: obsolete negative regulation of G1/S transition of mitotic cell cycle by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates G1/S transition of mitotic cell cycle." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100053
name: obsolete positive regulation of sulfate assimilation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sulfate assimilation." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100054
name: obsolete positive regulation of flocculation via cell wall protein-carbohydrate interaction by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates flocculation via cell wall protein-carbohydrate interaction." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100055
name: obsolete positive regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phosphatidylserine biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100056
name: obsolete negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phosphatidylserine biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100057
name: obsolete regulation of phenotypic switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates phenotypic switching." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100058
name: obsolete positive regulation of phenotypic switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phenotypic switching." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100059
name: obsolete negative regulation of phenotypic switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phenotypic switching." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100060
name: obsolete negative regulation of SREBP signaling pathway by DNA binding
namespace: molecular_function
def: "OBSOLETE. Any DNA binding that negatively regulates SREBP signaling pathway." [GOC:cjm, GOC:obol]
comment: The reason for obsoletion is that this term should be represented by a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100061
name: obsolete negative regulation of SREBP signaling pathway by transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. Any transcription factor catabolic process process that negatively regulates SREBP signaling pathway." [GOC:cjm, GOC:obol]
comment: The reason for obsoletion is that this term should be represented by a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100062
name: obsolete positive regulation of SREBP signaling pathway by transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. Any transcription factor catabolic process process that positively_regulates SREBP signaling pathway." [GOC:cjm, GOC:obol]
comment: The reason for obsoletion is that this term should be represented by a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100063
name: obsolete regulation of dipeptide transmembrane transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates dipeptide transmembrane transport." [GOC:cjm, GOC:obol]
comment: The term was obsoleted because it is better represented by a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100064
name: obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates filamentous growth of a population of unicellular organisms in response to starvation." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100065
name: obsolete negative regulation of leucine import by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates leucine import." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100066
name: obsolete negative regulation of induction of conjugation with cellular fusion by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates induction of conjugation with cellular fusion." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100067
name: obsolete positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. Any canonical Wnt signaling pathway process that positively_regulates spinal cord association neuron differentiation." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0060070
consider: GO:1902831

[Term]
id: GO:0100068
name: obsolete positive regulation of pyrimidine-containing compound salvage by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates pyrimidine-containing compound salvage." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100069
name: obsolete negative regulation of neuron apoptotic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates neuron apoptotic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0100070
name: obsolete regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates fatty acid biosynthetic process." [GOC:cjm, GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0101002
name: ficolin-1-rich granule
namespace: cellular_component
def: "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154]
synonym: "ficolin granule" RELATED []
synonym: "ficolin-1 rich granule" EXACT []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0101003
name: ficolin-1-rich granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a ficolin-1-rich granule." [GOC:mec, PMID:23650620]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0070820 ! tertiary granule
relationship: part_of GO:0101002 ! ficolin-1-rich granule

[Term]
id: GO:0101004
name: cytolytic granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the cytolytic granule." [PMID:17272266, PMID:21247065]
is_a: GO:0005765 ! lysosomal membrane
relationship: part_of GO:0044194 ! cytolytic granule

[Term]
id: GO:0101005
name: deubiquitinase activity
namespace: molecular_function
alt_id: GO:1904265
def: "An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:mec, PMID:30783221]
comment: There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases.
synonym: "ubiquitinyl hydrolase activity" EXACT []
xref: Reactome:R-HSA-9674127 "USP30 deubiquitinates ATM dimer:Ub-p-PEX5"
is_a: GO:0019783 ! ubiquitin-like protein peptidase activity

[Term]
id: GO:0101006
name: protein histidine phosphatase activity
namespace: molecular_function
alt_id: GO:0008969
def: "Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate." [EC:3.9.1.3]
comment: This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- (RHEA:47964) and tele- (RHEA:47960) nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) (EC:3.9.1.3).
synonym: "phosphohistidine phosphatase activity" BROAD []
xref: EC:3.9.1.3
is_a: GO:0004721 ! phosphoprotein phosphatase activity
is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds

[Term]
id: GO:0101007
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:0071472

[Term]
id: GO:0101008
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to increased salt
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:0071472

[Term]
id: GO:0101010
name: pulmonary blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing pulmonary blood vessels." [GOC:mec]
synonym: "pulmonary blood vessel remodelling" EXACT []
is_a: GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0101013
name: mechanosensitive voltage-gated sodium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:21041530, PMID:26838316]
synonym: "mechanically-modulated voltage-gated sodium channel activity" EXACT []
is_a: GO:0005248 ! voltage-gated sodium channel activity
is_a: GO:0140135 ! mechanosensitive monoatomic cation channel activity

[Term]
id: GO:0101014
name: [isocitrate dehydrogenase (NADP+)] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate." [PMID:6292732]
synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5]
xref: MetaCyc:ICITDEHASE-KIN-PHOSPHA
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0101016
name: FMN-binding domain binding
namespace: molecular_function
def: "Binding to the FMN-binding domain of a protein." [PMID:15752726]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0101017
name: regulation of mitotic DNA replication initiation from late origin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827]
synonym: "regulation of late replication origin firing" EXACT [GOC:dph, GOC:krc, PMID:19221029]
is_a: GO:1903466 ! regulation of mitotic DNA replication initiation

[Term]
id: GO:0101018
name: negative regulation of mitotic DNA replication initiation from late origin
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827]
synonym: "negative regulation of late replication origin firing" EXACT [GOC:dph, GOC:krc, PMID:19221029]
is_a: GO:0101017 ! regulation of mitotic DNA replication initiation from late origin
is_a: GO:1903467 ! negative regulation of mitotic DNA replication initiation

[Term]
id: GO:0101019
name: nucleolar exosome (RNase complex)
namespace: cellular_component
def: "A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]
is_a: GO:0000176 ! nuclear exosome (RNase complex)
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0101020
name: estrogen 16-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: estrogen + reduced [NADPH--hemoprotein reductase] + O2 = 16-alpha-hydroxyestrogen + oxidized [NADPH--hemoprotein reductase] + H2O." [GOC:BHF]
synonym: "oestrogen 16-alpha-hydroxylase activity" EXACT []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0101021
name: estrogen 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O." [GOC:BHF, GOC:rl, PMID:14559847]
synonym: "oestrogen 2-hydroxylase activity" EXACT []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0101023
name: vascular endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774]
is_a: GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0101024
name: mitotic nuclear membrane organization
namespace: biological_process
def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis." [GOC:vw, PMID:15147872]
comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown.
synonym: "nuclear membrane organization involved in mitotic nuclear division" EXACT []
is_a: GO:0071763 ! nuclear membrane organization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0101025
name: nuclear membrane biogenesis
namespace: biological_process
def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw]
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0071763 ! nuclear membrane organization

[Term]
id: GO:0101026
name: mitotic nuclear membrane biogenesis
namespace: biological_process
def: "A process in which the nuclear inner or outer membrane is synthesized, aggregates, and bonds together during mitotic nuclear division." [GOC:vw, PMID:26869222]
synonym: "nuclear membrane biogenesis involved in mitotic nuclear division" EXACT []
is_a: GO:0061024 ! membrane organization
is_a: GO:0101025 ! nuclear membrane biogenesis
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0101027
name: optical nerve axon regeneration
namespace: biological_process
def: "The regrowth of axons of the optical nerve following their loss or damage." [GOC:pga, PMID:16699509]
is_a: GO:0031103 ! axon regeneration

[Term]
id: GO:0101028
name: obsolete positive regulation of liquid surface tension
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the surface tension of a liquid." [GOC:sl, PMID:20949060]
comment: Never been used.
synonym: "positive regulation of surface tension of a liquid" EXACT []
is_obsolete: true

[Term]
id: GO:0101029
name: obsolete negative regulation of liquid surface tension
namespace: biological_process
def: "OBSOLETE. Any process that prevents or reduces the surface tension of a liquid." [GOC:sl, PMID:20949060]
comment: Never been used.
synonym: "negative regulation of surface tension of a liquid" EXACT []
is_obsolete: true

[Term]
id: GO:0101030
name: tRNA-guanine transglycosylation
namespace: biological_process
def: "The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0101031
name: protein folding chaperone complex
namespace: cellular_component
def: "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]
comment: An example of this is HSP90AB1 in human (P08238) in PMID:21855797 (inferred from direct assay).
synonym: "chaperone complex" BROAD []
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0102001
name: isoleucine N-monooxygenase (oxime forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ = (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.14.39]
xref: EC:1.14.14.39
xref: MetaCyc:1.14.13.117-RXN
xref: RHEA:28602
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102002
name: valine N-monooxygenase (oxime forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ = (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.14.38]
xref: EC:1.14.14.38
xref: MetaCyc:1.14.13.118-RXN
xref: RHEA:28606
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102003
name: acyl-lipid (11-3)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O or an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O." [EC:1.14.19.4]
synonym: "acyl-lipid 8-desaturase" EXACT [EC:1.14.19.4]
synonym: "Delta(8)-desaturase" EXACT [EC:1.14.19.4]
synonym: "Delta8-sphingolipid desaturase activity" EXACT []
xref: EC:1.14.19.4
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102004
name: obsolete 2-octaprenyl-6-hydroxyphenol methylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine." [GOC:curators]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102006
name: obsolete 4-methyl-2-oxopentanoate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) = isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)." [GOC:curators]
comment: The reason for obsoletion is that this term is equivalent to branched-chain alpha-keto acid dehydrogenase activity.
is_obsolete: true
replaced_by: GO:0047101

[Term]
id: GO:0102007
name: acyl-L-homoserine-lactone lactonohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine." [EC:3.1.1.81]
xref: EC:3.1.1.81
xref: MetaCyc:3.1.1.81-RXN
xref: Reactome:R-HSA-8932633 "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE"
xref: Reactome:R-HSA-9756136 "PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV"
xref: Reactome:R-HSA-9756150 "PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV"
xref: Reactome:R-HSA-9756177 "PON1,3 hydrolyse ATVL to ATV"
xref: RHEA:22576
is_a: GO:0046573 ! lactonohydrolase activity

[Term]
id: GO:0102009
name: proline dipeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal = L-proline + a standard alpha amino acid." [EC:3.4.13.9]
xref: EC:3.4.13.9
xref: MetaCyc:3.4.13.9-RXN
xref: RHEA:76407
is_a: GO:0016805 ! dipeptidase activity

[Term]
id: GO:0102013
name: ATPase-coupled L-glutamate tranmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in)." [RHEA:29035]
synonym: "L-glutamate-importing ATPase activity" RELATED []
xref: MetaCyc:ABC-13-RXN
xref: RHEA:29035
is_a: GO:0015426 ! ATPase-coupled polar amino acid-transporter activity

[Term]
id: GO:0102014
name: beta-D-galactose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O = ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+." [RHEA:30011]
xref: RHEA:30011
is_a: GO:0015407 ! ABC-type monosaccharide transporter activity

[Term]
id: GO:0102025
name: ABC-type thiosulfate transporter activity
namespace: molecular_function
alt_id: GO:0032146
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [GOC:mlg, GOC:pz]
synonym: "ATPase-coupled thiosulfate transmembrane transporter activity" RELATED []
synonym: "thiosulfate transmembrane-transporting ATPase activity" RELATED []
synonym: "thiosulphate ABC transporter activity" EXACT []
xref: MetaCyc:ABC-7-RXN
xref: RHEA:29871
is_a: GO:0015117 ! thiosulfate transmembrane transporter activity
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0102027
name: obsolete S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine = menaquinol-8 + H+ + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of demethylmenaquinone methyltransferase activity ; GO:0043770.
is_obsolete: true
replaced_by: GO:0043770

[Term]
id: GO:0102028
name: obsolete cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate." [GOC:pz, PMID:5922970, PMID:9531508]
comment: The reason for obsoletion is that this term is equivalent to GO:0003962 cystathionine gamma-synthase activity, with the same EC cross reference.
is_obsolete: true
replaced_by: GO:0003962

[Term]
id: GO:0102029
name: D-lactate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol." [GOC:pz, PMID:10944213, PMID:4575624, RHEA:51468]
xref: EC:1.1.5.12
xref: MetaCyc:DLACTDEHYDROGFAD-RXN
xref: RHEA:51468
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0102030
name: obsolete dTDP-L-rhamnose synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102031
name: 4-acetamido-4,6-dideoxy-D-galactose transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol = H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP." [EC:2.4.1.325, GOC:pz]
xref: EC:2.4.1.325
xref: MetaCyc:FUC4NACTRANS-RXN
xref: RHEA:28759
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102033
name: long-chain fatty acid omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:krc, PMID:18544608, RHEA:56748]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "cytochrome P450 fatty acid omega-hydroxylase activity" RELATED []
xref: EC:1.14.14.80
xref: MetaCyc:RXN-16394
xref: RHEA:56748
is_a: GO:0120250 ! fatty acid omega-hydroxylase activity

[Term]
id: GO:0102035
name: obsolete 2-methylpropanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-methylpropanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]." [PMID:3988734]
comment: This term was obsoleted because it represents a specific substrate of short-chain 2-methyl fatty acyl-CoA dehydrogenase activity ; GO:0003853.
is_obsolete: true
replaced_by: GO:0003853

[Term]
id: GO:0102036
name: methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] = an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]." [EC:2.1.1.258, GOC:pz, PMID:7928975]
xref: EC:2.1.1.258
xref: MetaCyc:METHCOCLTH-RXN
xref: RHEA:45200
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102037
name: 4-nitrotoluene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 = 4-nitrobenzyl alcohol + NAD+ + H2O." [GOC:pz]
xref: MetaCyc:R361-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102038
name: 4-nitrobenzyl alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + hydrogen peroxide." [GOC:pz]
xref: MetaCyc:R362-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0102039
name: NADH-dependent peroxiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroperoxide + H+ + NADH = an alcohol + H2O + NAD+." [GOC:pz, PMID:12517450, RHEA:62628]
synonym: "alkylhydroperoxide reductase activity" EXACT []
xref: EC:1.11.1.26
xref: MetaCyc:R4-RXN
xref: Reactome:R-HSA-1222526 "AhpC reduces peroxidated lipids"
xref: RHEA:62628
is_a: GO:0051920 ! peroxiredoxin activity

[Term]
id: GO:0102040
name: obsolete fumarate reductase (menaquinone)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone." [GOC:pz, PMID:11850430]
comment: This term was obsoleted because EC merged it into the more general succinate dehydrogenase (ubiquinone) activity ; GO:0008177.
is_obsolete: true
replaced_by: GO:0008177

[Term]
id: GO:0102041
name: 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase
namespace: molecular_function
def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid." [GOC:pz, RHEA:35951]
xref: EC:2.5.1.105
xref: MetaCyc:RXN-10009
xref: RHEA:35951
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0102042
name: dehydroquinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+." [GOC:pz, RHEA:25956]
xref: EC:1.4.1.24
xref: MetaCyc:RXN-10032
xref: RHEA:25956
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102043
name: isopentenyl phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) = isopentenyl diphosphate(3-) + ADP(3-)." [GOC:pz, PMID:19928876, RHEA:33963]
xref: EC:2.7.4.26
xref: MetaCyc:RXN-10068
xref: RHEA:33963
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0102044
name: 3-chlorobenzoate-4,5-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz]
xref: MetaCyc:RXN-10421
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0102045
name: 3-chlorobenzoate-3,4-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor." [GOC:pz, PMID:8285670]
xref: MetaCyc:RXN-10422
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0102046
name: 3,4-dichlorobenzoate-4,5-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor = 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz, PMID:9322760]
xref: MetaCyc:RXN-10427
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0102047
name: indole-3-acetyl-glycine synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) = H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623]
xref: MetaCyc:RXN-10429
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0102048
name: indole-3-acetyl-isoleucine synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) = H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623]
xref: MetaCyc:RXN-10430
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0102049
name: indole-3-acetyl-methionine synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) = H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623]
xref: MetaCyc:RXN-10431
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0102050
name: obsolete indole-3-acetyl-tyrosine synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) = H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102051
name: obsolete indole-3-acetyl-tryptophan synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) = H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102052
name: obsolete indole-3-acetyl-proline synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) = H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102053
name: obsolete (-)-jasmonoyl-isoleucine synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) = H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of jasmonate-amino synthetase activity ; GO:0080123.
is_obsolete: true
replaced_by: GO:0080123

[Term]
id: GO:0102054
name: maleylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O = H+ + maleate(2-) + pyruvate." [GOC:pz, PMID:7400101, RHEA:47956]
xref: EC:3.7.1.23
xref: MetaCyc:RXN-10447
xref: RHEA:47956
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0102055
name: obsolete 12-hydroxyjasmonate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate." [GOC:curators]
comment: This term was obsoleted because it represents the same activity as hydroxyjasmonate sulfotransferase activity ; GO:0080131.
is_obsolete: true
replaced_by: GO:0080131

[Term]
id: GO:0102056
name: obsolete 11-hydroxyjasmonate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as hydroxyjasmonate sulfotransferase activity ; GO:0080131.
is_obsolete: true
replaced_by: GO:0080131

[Term]
id: GO:0102057
name: obsolete jasmonoyl-valine synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid = AMP(2-) + diphosphoric acid + a jasmonoyl-valine." [GOC:pz, PMID:17291501]
comment: This term was obsoleted because it represents a specific substrate of jasmonate-amino synthetase activity ; GO:0080123.
is_obsolete: true
replaced_by: GO:0080123

[Term]
id: GO:0102058
name: obsolete jasmonoyl-leucine synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid = AMP(2-) + diphosphoric acid + a jasmonoyl-leucine." [GOC:pz, PMID:17291501]
comment: This term was obsoleted because it represents a specific substrate of jasmonate-amino synthetase activity ; GO:0080123.
is_obsolete: true
replaced_by: GO:0080123

[Term]
id: GO:0102059
name: (2Z,6Z)-farnesyl diphosphate synthase activity
namespace: molecular_function
alt_id: GO:0102192
def: "Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate." [RHEA:27810]
synonym: "2-cis,6-cis-farnesyl pyrophosphate synthase activity" EXACT []
synonym: "cis,cis-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.92]
synonym: "neryl-diphosphate:isopentenyl-diphosphate cistransferase activity" NARROW []
synonym: "Z,Z-farnesyl pyrophosphate synthase activity" EXACT [EC:2.5.1.92]
synonym: "Z,Z-FPP synthase activity" EXACT [EC:2.5.1.92]
synonym: "zFPS activity" EXACT [EC:2.5.1.92]
xref: EC:2.5.1.92
xref: MetaCyc:RXN-10481
xref: RHEA:27810
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0102060
name: endo-alpha-bergamotene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphoric acid." [GOC:pz, RHEA:30471]
synonym: "endo-alpha-bergamontene synthase activity" EXACT []
xref: EC:4.2.3.54
xref: MetaCyc:RXN-10482
xref: RHEA:30471
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102061
name: endo-beta-bergamotene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphoric acid." [GOC:pz, RHEA:30467]
synonym: "(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)" EXACT [EC:4.2.3.53]
synonym: "(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene" EXACT [EC:4.2.3.53]
synonym: "endo-beta-bergamontene synthase activity" EXACT []
xref: EC:4.2.3.53
xref: MetaCyc:RXN-10483
xref: RHEA:30467
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102062
name: alpha-santalene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-alpha-santalene + diphosphoric acid." [EC:4.2.3.50, GOC:pz]
xref: EC:4.2.3.50
xref: MetaCyc:RXN-10567
xref: RHEA:30463
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102063
name: obsolete beta-curcumene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + (-)-beta-curcumene." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102064
name: gamma-curcumene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = gamma-curcumene + diphosphoric acid." [EC:4.2.3.94, GOC:pz]
xref: EC:4.2.3.94
xref: MetaCyc:RXN-10599
xref: RHEA:32031
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102065
name: obsolete patchoulene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + gamma-patchoulene." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102066
name: obsolete alpha-patchoulene synthase activityy
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102067
name: geranylgeranyl diphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+." [EC:1.3.1.83, GOC:pz]
xref: EC:1.3.1.83
xref: MetaCyc:RXN-10625
xref: RHEA:26229
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102068
name: alpha-humulene 10-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ = 10-hydroxy-alpha-humulene + NADP + H2O." [EC:1.14.14.113, GOC:pz]
xref: EC:1.14.14.113
xref: MetaCyc:RXN-10628
xref: RHEA:32491
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102069
name: zerumbone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD = zerumbone + NADH + H+." [EC:1.1.1.326, GOC:pz]
xref: EC:1.1.1.326
xref: MetaCyc:RXN-10629
xref: RHEA:32327
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102070
name: obsolete 18-hydroxyoleate peroxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide = 9,10-epoxy-18-hydroxystearate + a lipid alcohol." [GOC:pz, PMID:12226220, PMID:14535881, PMID:468835]
comment: This term was obsoleted because GO:0102070 represents a specific substrate of plant seed peroxidase activity ; GO:1990137.
is_obsolete: true
replaced_by: GO:1990137

[Term]
id: GO:0102071
name: obsolete 9,10-epoxy-18-hydroxystearate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O = 9,10,18-trihydroxystearate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102072
name: obsolete 3-oxo-cis-Delta9-hexadecenoyl-[acp] reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxy cis Delta9-hexadecenoyl-[acp] = NADPH + H+ + a 3-oxo-cis-Delta9-hexadecenoyl-[acp]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate, and is beyond the specificity of GO.
is_obsolete: true
consider: GO:0004316

[Term]
id: GO:0102073
name: obsolete OPC8-trans-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: OPC8-3-hydroxyacyl-CoA = OPC8-trans-2-enoyl-CoA + H2O." [EC:4.2.1.17, GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of enoyl-CoA hydratase activity ; GO:0004300.
is_obsolete: true
replaced_by: GO:0004300

[Term]
id: GO:0102074
name: obsolete OPC6-trans-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: OPC6-3-hydroxyacyl-CoA = OPC6-trans-2-enoyl-CoA + H2O." [EC:4.2.1.17, GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of enoyl-CoA hydratase activity ; GO:0004300.
is_obsolete: true
replaced_by: GO:0004300

[Term]
id: GO:0102075
name: obsolete OPC4-trans-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: OPC4-3-hydroxyacyl-CoA = OPC4-trans-2-enoyl-CoA + H2O." [EC:4.2.1.17, GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of enoyl-CoA hydratase activity ; GO:0004300.
is_obsolete: true
replaced_by: GO:0004300

[Term]
id: GO:0102076
name: beta,beta-carotene-9',10'-cleaving oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + O2 = 10'-apo-beta-carotenal + beta-ionone." [EC:1.13.11.71, GOC:pz]
xref: EC:1.13.11.71
xref: MetaCyc:RXN-10741
xref: RHEA:26389
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102080
name: phenylacetyl-coenzyme A:glycine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetyl-CoA + glycine = H+ + phenylacetylglycine + coenzyme A." [EC:2.3.1.192, GOC:pz]
xref: EC:2.3.1.192
xref: MetaCyc:RXN-10821
xref: RHEA:27850
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102081
name: obsolete homotaurine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) = 3-sulfopropanal + L-glutamate(1-)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102082
name: demethylrebeccamycin--D-glucose O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine = H+ + rebeccamycin + S-adenosyl-L-homocysteine." [EC:2.1.1.164, GOC:pz]
xref: EC:2.1.1.164
xref: MetaCyc:RXN-10847
xref: RHEA:27353
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102083
name: 7,8-dihydromonapterin aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydromonapterin = glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol." [GOC:pz, PMID:15107504]
xref: MetaCyc:RXN-10857
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0102084
name: obsolete L-dopa O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine = 3-O-methyldopa + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: The reason for obsoletion is that it is more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0016206

[Term]
id: GO:0102085
name: obsolete N-(4-aminobenzoyl)-L-glutamate synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP = H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as N-(4-aminobenzoyl)-L-glutamate synthetase activity ; GO:0052625.
is_obsolete: true
replaced_by: GO:0052625

[Term]
id: GO:0102086
name: obsolete N-vanillate-L-glutamate synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP = H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as N-vanillate-L-glutamate synthetase activity ; GO:0052627.
is_obsolete: true
replaced_by: GO:0052627

[Term]
id: GO:0102087
name: obsolete N-benzoyl-L-glutamate synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: benzoate + L-glutamate + ATP = H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as N-benzoyl-L-glutamate synthetase activity ; GO:0052626.
is_obsolete: true
replaced_by: GO:0052626

[Term]
id: GO:0102088
name: obsolete N-(4-hydroxybenzoyl)-L-glutamate synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP = H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as N-(4-hydroxybenzoyl)-L-glutamate synthetase activity ; GO:0052628.
is_obsolete: true
replaced_by: GO:0052628

[Term]
id: GO:0102089
name: obsolete dehydroscoulerine synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as reticuline oxidase activity ; GO:0050468.
is_obsolete: true
replaced_by: GO:0050468

[Term]
id: GO:0102090
name: obsolete adrenaline O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine = metanephrine + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of catechol O-methyltransferase activity ; GO:0016206.
is_obsolete: true
replaced_by: GO:0016206

[Term]
id: GO:0102091
name: phosphatidylinositol-5-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate." [GOC:pz, PMID:12878591]
synonym: "phosphatidylinositol-5-phosphate 5-phosphatase activity" EXACT []
xref: MetaCyc:RXN-10962
is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity

[Term]
id: GO:0102093
name: obsolete acrylate:acyl-coA CoA transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acryloyl-CoA + H2O = acrylate + coenzyme A + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102094
name: obsolete S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol = S-adenosyl-L-homocysteine + H+ + a menaquinol." [GOC:pz, PMID:1444716, PMID:9045837]
comment: This term was obsoleted because it represents a specific substrate of demethylmenaquinone methyltransferase activity ; GO:0043770.
is_obsolete: true
replaced_by: GO:0043770

[Term]
id: GO:0102096
name: decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+." [EC:2.4.1.289, GOC:pz]
xref: EC:2.4.1.289
xref: MetaCyc:RXN-11070
xref: RHEA:34487
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102097
name: 22alpha-hydroxysteroid 23-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Also converts 3-epi-6-deoxocathasterone to 6-deoxotyphasterol." [EC:1.14.14.147]
synonym: "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity" EXACT []
xref: EC:1.14.14.147
xref: MetaCyc:RXN-11101
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102098
name: D-galacturonate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+." [EC:1.1.1.365, GOC:pz]
xref: EC:1.1.1.365
xref: MetaCyc:RXN-11151
xref: RHEA:26345
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102099
name: FAD-dependent urate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 = 5-hydroxyisouric acid + NAD + H2O." [EC:1.14.13.113, GOC:pz]
xref: EC:1.14.13.113
xref: MetaCyc:RXN-11186
xref: RHEA:27329
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102100
name: mycothiol-arsenate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenate + mycothiol = mycothiol-arsenate conjugate + H2O." [EC:2.8.4.2, GOC:pz]
xref: EC:2.8.4.2
xref: MetaCyc:RXN-11187
xref: RHEA:27349
is_a: GO:0050497 ! alkylthioltransferase activity

[Term]
id: GO:0102102
name: homocarnosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate." [GOC:pz, RHEA:59568]
xref: MetaCyc:RXN-11222
xref: RHEA:59568
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0102103
name: demethoxycurcumin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O = bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide." [EC:2.3.1.219]
xref: EC:2.3.1.219
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102104
name: obsolete demethoxycurcumin synthase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as demethoxycurcumin synthase activity ; GO:0102103.
is_obsolete: true
replaced_by: GO:0102103

[Term]
id: GO:0102105
name: obsolete demethoxycurcumin synthase activity from feruloylacetyl-CoA
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of demethoxycurcumin synthase activity ; GO:0102103.
is_obsolete: true
replaced_by: GO:0102103

[Term]
id: GO:0102106
name: curcumin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O = curcumin + 2 coenzyme A(4-) + carbon dioxide." [EC:2.3.1.217, GOC:pz]
xref: EC:2.3.1.217
xref: MetaCyc:RXN-11226
xref: RHEA:34823
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102109
name: tricaffeoyl spermidine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine = 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine." [GOC:pz, PMID:19077165]
xref: MetaCyc:RXN-11261
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102111
name: obsolete gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 = gibberellin A29 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of gibberellin 3-beta-dioxygenase activity ; GO:0016707.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102114
name: obsolete caprate dehydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: decanoate + NADPH + O2 + H+ = 10-hydroxycaprate + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate and is beyond the scope of GO MF.
is_obsolete: true
replaced_by: GO:0140981

[Term]
id: GO:0102115
name: peptidoglycan asparagine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid." [EC:6.3.1.-, GOC:pz]
xref: MetaCyc:RXN-11338
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0102116
name: obsolete laurate hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ = 11-hydroxylaurate + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate and is beyond the scope of GO MF.
is_obsolete: true
replaced_by: GO:0140981

[Term]
id: GO:0102117
name: gibberellin A9 carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine = gibberellin A9 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.275, GOC:pz]
xref: EC:2.1.1.275
xref: MetaCyc:RXN-11358
xref: RHEA:36119
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102118
name: gibberellin A4 carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine = gibberellin A4 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.276, GOC:pz]
xref: EC:2.1.1.276
xref: MetaCyc:RXN-11359
xref: RHEA:36107
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102119
name: obsolete gibberellin A20 carboxyl methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102121
name: obsolete ceramidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as N-acylsphingosine amidohydrolase activity ; GO:0017040.
is_obsolete: true
replaced_by: GO:0017040

[Term]
id: GO:0102122
name: obsolete gibberellin A34 carboxyl methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102123
name: obsolete gibberellin A4 16alpha,17 epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H = 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102124
name: obsolete gibberellin A12 16alpha,17 epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H = 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102125
name: obsolete gibberellin A9 16alpha,17 epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H = 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102126
name: coniferyl aldehyde 5-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 = 5-hydroxy-coniferaldehyde + NADP + H2O." [GOC:pz]
xref: MetaCyc:RXN-1142
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102127
name: 8-oxoguanine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O = 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium." [EC:3.5.4.32, GOC:pz]
xref: EC:3.5.4.32
xref: MetaCyc:RXN-11455
xref: RHEA:32067
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0102128
name: obsolete chalcone synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide." [GOC:pz, PMID:20356611]
comment: This term was obsoleted because it represents the same activity as naringenin-chalcone synthase activity ; GO:0016210.
is_obsolete: true
replaced_by: GO:0016210

[Term]
id: GO:0102130
name: malonyl-CoA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester." [GOC:pz, RHEA:17105]
xref: EC:2.1.1.197
xref: MetaCyc:RXN-11475
xref: RHEA:17105
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102131
name: obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxyglutaryl-[acp] methyl ester = NADPH + H+ + a 3-oxo-glutaryl-[acp] methyl ester." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate, and is beyond the specificity of GO.
is_obsolete: true
consider: GO:0004316

[Term]
id: GO:0102132
name: obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxypimeloyl-[acp] methyl ester = NADPH + H+ + a 3-oxo-pimeloyl-[acp] methyl ester." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate, and is beyond the specificity of GO.
is_obsolete: true
consider: GO:0004316

[Term]
id: GO:0102133
name: obsolete limonene hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ = (4R)-perillyl alcohol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102134
name: (22S)-22-hydroxy-campesterol C-23 hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 = (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O." [GOC:pz]
xref: MetaCyc:RXN-11529
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102135
name: (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 = (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O." [GOC:pz]
xref: MetaCyc:RXN-11530
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102136
name: obsolete 3-epi-6-deoxocathasterone C-23 hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reductase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O." [GOC:pz, PMID:17138693]
comment: This term was obsoleted because it represents the same reaction as (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity ; GO:0102097.
is_obsolete: true
replaced_by: GO:0102097

[Term]
id: GO:0102137
name: obsolete 7-oxateasterone synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of brassinolide synthase activity ; GO:0102734.
is_obsolete: true
replaced_by: GO:0102734

[Term]
id: GO:0102138
name: obsolete 7-oxatyphasterol synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + typhasterol = 7-oxatyphasterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of brassinolide synthase activity ; GO:0102734.
is_obsolete: true
replaced_by: GO:0102734

[Term]
id: GO:0102139
name: obsolete 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity ; GO:0018768.
is_obsolete: true
replaced_by: GO:0018768

[Term]
id: GO:0102140
name: heparan sulfate N-deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine." [RHEA:70587]
xref: RHEA:70587
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102141
name: obsolete [chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102142
name: [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate = adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate." [MetaCyc:RXN-11561]
xref: MetaCyc:RXN-11561
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0102143
name: carboxynorspermidine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carboxynorspermidine + H2O + NADP+ = H+ + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine. Also converts carboxyspermidine to putrescine." [EC:1.5.1.43]
synonym: "carboxynorspermidine dehydrogenase I activity" NARROW []
synonym: "carboxynorspermidine dehydrogenase II activity" NARROW []
xref: EC:1.5.1.43
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102144
name: obsolete carboxyspermidine dehydrogenase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: carboxyspermidine + H2O + NADP = L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as carboxynorspermidine dehydrogenase activity; GO:0102143.
is_obsolete: true
replaced_by: GO:0102143

[Term]
id: GO:0102145
name: (3R)-(E)-nerolidol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphoric acid." [GOC:pz, RHEA:27534]
xref: EC:4.2.3.49
xref: MetaCyc:RXN-11575
xref: RHEA:27534
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102146
name: tricetin O-methytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine." [GOC:pz, RHEA:27493]
xref: MetaCyc:RXN-11582
xref: RHEA:27493
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102147
name: obsolete 3'-O-methyltricetin O methyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102148
name: obsolete N-acetyl-beta-D-galactosaminidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan." [GOC:pz]
comment: This term was obosoleted because it was created by error.
is_obsolete: true
consider: GO:0004563
consider: GO:0032428

[Term]
id: GO:0102149
name: farnesylcysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O = (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide." [EC:1.8.3.6, GOC:pz]
xref: EC:1.8.3.6
xref: MetaCyc:RXN-11623
xref: RHEA:30231
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0102150
name: obsolete 3-oxo-myristoyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O = 3-oxo-myristate + coenzyme A + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiolester hydrolase activity ; GO:0016790.
is_obsolete: true
consider: GO:0016790

[Term]
id: GO:0102151
name: obsolete 3-oxo-myristate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-oxo-myristate + H+ = 2-tridecanone + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-oxolaurate decarboxylase activity ; GO:0050410.
is_obsolete: true
replaced_by: GO:0050410

[Term]
id: GO:0102152
name: obsolete Delta12-linoleate epoxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 = 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102154
name: obsolete 8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose = 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-hydroxyflavanone C-glucosyltransferase activity ; GO:0120514.
is_obsolete: true
replaced_by: GO:0120514

[Term]
id: GO:0102155
name: S-sulfolactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-sulfonatolactate + NAD = 3-sulfonatopyruvate(2-) + NADH + H+." [EC:1.1.1.310, GOC:pz]
xref: EC:1.1.1.310
xref: MetaCyc:RXN-11689
xref: RHEA:28194
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102156
name: obsolete 2,5-DHBA UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose = 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102157
name: (R)-sulfopropanediol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD = 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+." [GOC:pz, PMID:20150239]
xref: MetaCyc:RXN-11729
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102158
name: very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:45812]
synonym: "very-long-chain 3-hydroxyacyl-CoA dehydratase activity" EXACT []
xref: EC:4.2.1.134
xref: MetaCyc:RXN-11750
xref: RHEA:45812
is_a: GO:0018812 ! 3-hydroxyacyl-CoA dehydratase activity

[Term]
id: GO:0102159
name: baicalein 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein = H+ + UDP + baicalin." [RHEA:28314]
xref: MetaCyc:RXN-11755
xref: RHEA:28314
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102160
name: cyanidin 3-O-glucoside 2-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate = H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP." [RHEA:28258]
synonym: "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity" EXACT []
xref: EC:2.4.1.254
xref: MetaCyc:RXN-11756
xref: RHEA:28258
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102161
name: copal-8-ol diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: copal-8-ol diphosphate = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O." [EC:4.2.1.133, GOC:pz]
xref: EC:4.2.1.133
xref: MetaCyc:RXN-11772
xref: RHEA:32703
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0102162
name: all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 = all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial." [EC:1.13.11.75, GOC:pz]
xref: EC:1.13.11.75
xref: MetaCyc:RXN-11783
xref: RHEA:26385
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102163
name: obsolete 3-hydroxyacyl-CoA-acyl carrier protein transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102164
name: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ = 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O." [EC:1.14.13.182, GOC:pz]
xref: EC:1.14.13.182
xref: MetaCyc:RXN-11849
xref: RHEA:37871
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102165
name: (Z)-3-hexen-1-ol acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol = (3Z)-hex-3-en-1-yl acetate + coenzyme A." [GOC:pz, RHEA:28254]
xref: EC:2.3.1.195
xref: MetaCyc:RXN-11852
xref: RHEA:28254
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102166
name: obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] = N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of \n[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine \nO-N-acetyl-alpha-D-glucosaminase activity ; GO:0102571.
is_obsolete: true
replaced_by: GO:0102571

[Term]
id: GO:0102167
name: obsolete [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] = N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine \nO-N-acetyl-alpha-D-glucosaminase activity ; GO:0102571.
is_obsolete: true
replaced_by: GO:0102571

[Term]
id: GO:0102168
name: 5-methyl-phenazine-1-carboxylate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine." [RHEA:49112]
xref: EC:2.1.1.327
xref: MetaCyc:RXN-11897
xref: RHEA:49112
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102169
name: 5-methylphenazine-1-carboxylate 1-monooxygenase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyl-phenazine-1-carboxylate + 2 H+ + NADH + O2 = CO2 + H2O + NAD+ + pyocyanin. Also converts phenazine-1-carboxylate into 1-hydroxyphenazine." [EC:1.14.13.218, PMID:11591691]
synonym: "pyocyanin hydroxylase activity" RELATED []
xref: EC:1.14.13.218
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102170
name: 5-epi-aristolochene-1,3-dihydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 = capsidiol + 2 NADP + 2 H2O." [EC:1.14.14.149, GOC:pz]
xref: EC:1.14.14.149
xref: MetaCyc:RXN-11908
xref: RHEA:28226
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102171
name: DMNT synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] = (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H+ + 2 H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:55424]
xref: EC:1.14.14.59
xref: MetaCyc:RXN-11911
xref: RHEA:55424
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102172
name: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O." [GOC:pz, RHEA:58860]
xref: MetaCyc:RXN-11925
xref: RHEA:58860
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102173
name: obsolete 24-methylenecycloartanol 4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102174
name: obsolete 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102175
name: 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH." [RHEA:34775]
xref: EC:1.1.1.418
xref: MetaCyc:RXN-11928
xref: RHEA:34775
is_a: GO:0000252 ! 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity

[Term]
id: GO:0102176
name: obsolete cycloeucalenone reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cycloeucalenone + NADPH + H+ = cycloeucalenol + NADP." [GOC:pz, PMID:4387005]
comment: This term was obsoleted because it represents a specific substrate of 3-keto sterol reductase activity ; GO:0000253.
is_obsolete: true
replaced_by: GO:0000253

[Term]
id: GO:0102177
name: 24-methylenelophenol methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ = 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [GOC:pz, PMID:11707264, RHEA:58872]
xref: EC:1.14.18.11
xref: MetaCyc:RXN-11930
xref: RHEA:58872
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102178
name: obsolete 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH = 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102179
name: obsolete 24-ethylidenelophenol 4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ = 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102180
name: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ = 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O." [GOC:pz, RHEA:59036]
xref: MetaCyc:RXN-11936
xref: RHEA:59036
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102181
name: obsolete 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 = 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102182
name: obsolete 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD = avenastenone + NADH + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102183
name: obsolete avenastenone reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: avenastenone + NADPH + H+ = avenasterol + NADP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-keto sterol reductase activity ; GO:0000253.
is_obsolete: true
replaced_by: GO:0000253

[Term]
id: GO:0102184
name: obsolete cycloartenol 4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cycloartenol + NADH + O2 + H+ = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102185
name: obsolete 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102186
name: obsolete 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 = 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102187
name: obsolete 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) = 4alpha,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3-one + NADH(2-) + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this reaction exists.
is_obsolete: true

[Term]
id: GO:0102188
name: obsolete 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ = 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102189
name: obsolete 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ = 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O." [GOC:pz]
comment: The term is only defined by a MetaCyc xref, which has been obsoleted.
is_obsolete: true

[Term]
id: GO:0102190
name: obsolete 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) = 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102191
name: obsolete 3-beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD+ = CO2 + cycloeucalenone + NADH." [GOC:curators]
comment: This term was obsoleted because it represents a specific substrate of 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity ; GO:0102175.
synonym: "3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity" EXACT []
synonym: "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0102175

[Term]
id: GO:0102193
name: protein-ribulosamine 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine = ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine." [EC:2.7.1.172, GOC:pz]
xref: EC:2.7.1.172
xref: MetaCyc:RXN-12003
xref: RHEA:48432
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0102194
name: protein-fructosamine 3-kinase activity
namespace: molecular_function
alt_id: GO:0030387
def: "Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine = ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine." [EC:2.7.1.171, GOC:pz, PMID:11016445]
synonym: "fructosamine-3-kinase activity" RELATED []
xref: EC:2.7.1.171
xref: MetaCyc:RXN-12005
xref: RHEA:59832
is_a: GO:0016301 ! kinase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0102195
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP = UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+." [EC:6.3.2.37, GOC:pz]
xref: EC:6.3.2.37
xref: MetaCyc:RXN-12042
xref: RHEA:25273
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0102196
name: cortisol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: cortisol + NADP+ = cortisone + NADPH + H+." [PMID:16216911, RHEA:68616]
xref: MetaCyc:RXN-12085
xref: RHEA:68616
is_a: GO:0070524 ! 11-beta-hydroxysteroid dehydrogenase (NADP+) activity

[Term]
id: GO:0102197
name: vinylacetate caboxylester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: but-3-enoate + H2O = allyl alcohol + formate." [GOC:pz, PMID:19555778]
xref: MetaCyc:RXN-12087
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102198
name: L-idonate 5-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+." [GOC:pz, RHEA:21172]
synonym: "L-idonate 5-dehydrogenase activity (NAD-dependent)" EXACT []
xref: EC:1.1.1.366
xref: MetaCyc:RXN-12107
xref: RHEA:21172
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102199
name: nitric oxide reductase (NAD(P)H) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD(p)+ + nitrous oxide = H+ + NAD(P)H + 2 nitric oxide." [EC:1.7.1.14]
synonym: "nitric oxide reductase activity (NAD(P)H-dependent) activity" EXACT []
xref: EC:1.7.1.14
xref: MetaCyc:RXN-12112
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0102200
name: obsolete N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as N-acylphosphatidylethanolamine-specific phospholipase D activity , GO:0070290.
is_obsolete: true
replaced_by: GO:0070290

[Term]
id: GO:0102201
name: (+)-2-epi-prezizaene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphoric acid." [GOC:pz, PMID:20175559, PMID:20201526]
xref: MetaCyc:RXN-12117
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102202
name: obsolete soladodine glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + solasodine = UDP + solasodine 3-O-beta-D-glucopyranoside + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0102203
name: obsolete brassicasterol glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol = UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0102205
name: obsolete cholesterol alpha-glucosyltransferase activity
namespace: molecular_function
alt_id: GO:0051505
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
synonym: "cholesterol allpha-glucosyltransferase activity" EXACT []
synonym: "cholesterol UDP-glucosyltransferase activity" RELATED []
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0102207
name: obsolete docosanoate omega-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:krc, GOC:pz, RHEA:40079]
comment: This term was obsoleted because it represents a specific substrate and is beyond the scope of GO MF.
synonym: "behenate omega-hydroxylase activity" EXACT []
is_obsolete: true
replaced_by: GO:0140692

[Term]
id: GO:0102208
name: 2-polyprenyl-6-hydroxyphenol methylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H+ + S-adenosyl-L-homocysteine." [GOC:pz, RHEA:31411]
xref: EC:2.1.1.222
xref: MetaCyc:RXN-12160
xref: RHEA:31411
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102209
name: trans-permethrin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-trans-permethrin + H2O = H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate." [EC:3.1.1.88, GOC:pz]
xref: EC:3.1.1.88
xref: MetaCyc:RXN-12167
xref: RHEA:30283
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102210
name: rhamnogalacturonan endolyase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a rhamnogalacturonan type I = [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]." [EC:4.2.2.23, GOC:pz]
xref: EC:4.2.2.23
xref: MetaCyc:RXN-12173
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0102211
name: unsaturated rhamnogalacturonyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose." [EC:3.2.1.172, GOC:pz]
xref: EC:3.2.1.172
xref: MetaCyc:RXN-12174
xref: RHEA:30927
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102212
name: unsaturated chondroitin disaccharide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate." [EC:3.2.1.180, GOC:pz]
xref: EC:3.2.1.180
xref: MetaCyc:RXN-12177
xref: RHEA:31647
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102213
name: obsolete in-chain hydroxy fatty acyl-CoA synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as medium-chain fatty acid-CoA ligase activity ; GO:0031956 and long-chain fatty acid-CoA ligase activity ; GO:0004467.
is_obsolete: true
consider: GO:0004467
consider: GO:0031956

[Term]
id: GO:0102214
name: obsolete omega-hydroxy fatty acyl-CoA synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as fatty acid ligase activity ; GO:0015645.
is_obsolete: true
consider: GO:0015645

[Term]
id: GO:0102215
name: thiocyanate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine = methyl thiocyanate + S-adenosyl-L-homocysteine." [RHEA:28014]
xref: EC:2.1.1.n4
xref: MetaCyc:RXN-12189
xref: RHEA:28014
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102216
name: obsolete maltodextrin water dikinase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as alpha-glucan, water dikinase activity ; GO:0050521.
is_obsolete: true
replaced_by: GO:0050521

[Term]
id: GO:0102217
name: obsolete 6-phosphoglucan, water dikinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as phosphoglucan, water dikinase activity GO:0051752.
is_obsolete: true
replaced_by: GO:0051752

[Term]
id: GO:0102218
name: obsolete starch, H2O dikinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as alpha-glucan, water dikinase activity ; GO:0050521.
is_obsolete: true
replaced_by: GO:0050521

[Term]
id: GO:0102219
name: obsolete phosphogluco-amylopectin water dikinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as phosphoglucan, water dikinase activity GO:0051752.
is_obsolete: true
replaced_by: GO:0051752

[Term]
id: GO:0102220
name: hydrogenase activity (NAD+, ferredoxin)
namespace: molecular_function
def: "Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin." [GOC:pz, RHEA:30279]
xref: EC:1.12.1.4
xref: MetaCyc:RXN-12215
xref: RHEA:30279
is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

[Term]
id: GO:0102222
name: obsolete 6-phosophogluco-3-phosphogluco-starch phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: m+q H2O + a 6-phosphogluco-3-phosphogluco-amylopectin = m+q hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin." [GOC:pz]
comment: This term was obsoleted because it was created by error.
is_obsolete: true

[Term]
id: GO:0102223
name: 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)
namespace: molecular_function
alt_id: GO:0102225
alt_id: GO:0102961
alt_id: GO:0102962
def: "Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 4 FADH2. This reaction consists of four successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene, 4,4'-diapo-zeta-carotene and 4,4'-diapolycopene as intermediates, and 4,4'-diapolycopene as the end product." [PMID:8002598, RHEA:31391]
synonym: "4,4'-diapo-zeta-carotene desaturase activity" NARROW []
synonym: "4,4'-diaponeurosporene desaturase activity" NARROW []
synonym: "4,4'-diapophytoene desaturase activity" BROAD []
synonym: "4,4'-diapophytofluene desaturase activity" NARROW []
xref: EC:1.3.8.2
xref: MetaCyc:RXN-12224
xref: RHEA:31391
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

[Term]
id: GO:0102224
name: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+." [RHEA:46316]
xref: MetaCyc:RXN-12236
xref: RHEA:46316
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102229
name: obsolete amylopectin maltohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin = amylopectin + maltose." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of beta-amylase activity ; GO:0016161.
is_obsolete: true
replaced_by: GO:0016161

[Term]
id: GO:0102232
name: acrolein reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acrolein + NADPH + H+ = propanal + NADP." [GOC:pz, PMID:21169366]
xref: MetaCyc:RXN-12281
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102233
name: obsolete crotonaldehyde redutase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ = butanal + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102234
name: obsolete but-1-en-3-one reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: buten-2-one + NADPH + H+ = butan-2-one + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102235
name: 1-penten-3-one reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-penten-3-one + NADPH + H+ = 1-pentan-3-one + NADP." [GOC:pz]
xref: MetaCyc:RXN-12295
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102236
name: trans-4-hexen-3-one reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ = hexan-3-one + NADP." [GOC:pz, PMID:21169366]
xref: MetaCyc:RXN-12296
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102237
name: ATP:farnesol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+." [GOC:pz, RHEA:61656]
synonym: "ATP-dependent farnesol kinase activity" RELATED []
xref: MetaCyc:RXN-12304
xref: RHEA:61656
is_a: GO:0052673 ! prenol kinase activity

[Term]
id: GO:0102238
name: ATP:geraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H+." [RHEA:61660]
synonym: "geraniol kinase activity (ATP-dependent) activity" EXACT []
xref: MetaCyc:RXN-12307
xref: RHEA:61660
is_a: GO:0052670 ! geraniol kinase activity

[Term]
id: GO:0102240
name: soyasapogenol B glucuronide galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate = H+ + UDP + soyasaponin III." [EC:2.4.1.272, GOC:pz]
xref: EC:2.4.1.272
xref: MetaCyc:RXN-12319
xref: RHEA:31487
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102241
name: soyasaponin III rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III = H+ + UDP + soyasaponin I." [EC:2.4.1.273, GOC:pz]
xref: EC:2.4.1.273
xref: MetaCyc:RXN-12320
xref: RHEA:31491
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102243
name: ATP:geranylgeraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H+." [RHEA:61664]
synonym: "ATP:geranylgeraniol phosphotransferase activity" EXACT []
xref: MetaCyc:RXN-12325
xref: RHEA:61664
is_a: GO:0052671 ! geranylgeraniol kinase activity

[Term]
id: GO:0102244
name: 3-aminopropanal dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-aminopropanal + H2O + NAD+ = beta-alanine + 2 H+ + NADH." [RHEA:30695]
xref: MetaCyc:RXN-12332
xref: RHEA:30695
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0102245
name: lupan-3beta,20-diol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O." [EC:4.2.1.128, GOC:pz]
xref: EC:4.2.1.128
xref: MetaCyc:RXN-12338
xref: RHEA:31351
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0102246
name: 6-amino-6-deoxyfutalosine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: aminodeoxyfutalosinate + H2O = dehypoxanthine futalosine + adenine." [EC:3.2.2.30, GOC:pz]
xref: EC:3.2.2.30
xref: MetaCyc:RXN-12346
xref: RHEA:33079
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0102247
name: obsolete malonyl-malonyl acyl carrier protein-condensing enzyme activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] = 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102248
name: obsolete diacylglycerol transacylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102249
name: phosphatidylcholine:diacylglycerol cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine." [GOC:pz, MetaCyc:RXN-12386]
xref: MetaCyc:RXN-12386
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0102250
name: obsolete linear malto-oligosaccharide phosphorylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 1,4-alpha-oligoglucan phosphorylase activity ; GO:0004645.
is_obsolete: true
replaced_by: GO:0004645

[Term]
id: GO:0102251
name: all-trans-beta-apo-10'-carotenal cleavage oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial." [EC:1.13.11.70, GOC:pz]
xref: EC:1.13.11.70
xref: MetaCyc:RXN-12393
xref: RHEA:26401
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102252
name: cellulose 1,4-beta-cellobiosidase activity (reducing end)
namespace: molecular_function
def: "Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains." [EC:3.2.1.176, GOC:pz]
xref: EC:3.2.1.176
xref: MetaCyc:RXN-12420
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102253
name: obsolete neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: neoagarobiose + H2O = 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of alpha-neoagaro-oligosaccharide hydrolase activity ; GO:0033954.
is_obsolete: true
replaced_by: GO:0033954

[Term]
id: GO:0102254
name: obsolete neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: neoagarotetraose + H2O = 3,6-anhydro-alpha-L-galactopyranose + agarotriose." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of alpha-neoagaro-oligosaccharide hydrolase activity ; GO:0033954.
is_obsolete: true
replaced_by: GO:0033954

[Term]
id: GO:0102255
name: obsolete neo-lambda-carrahexaose hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: neo-lambda-carrahexaose + H2O = neo-lambda-carratetraose + neo-lambda-carrabiose." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as lambda-carrageenase activity ; GO:0033957.
is_obsolete: true
replaced_by: GO:0033957

[Term]
id: GO:0102256
name: obsolete neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: neoagarohexaose + H2O = 3,6-anhydro-alpha-L-galactopyranose + agaropentaose." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of alpha-neoagaro-oligosaccharide hydrolase activity ; GO:0033954.
is_obsolete: true
replaced_by: GO:0033954

[Term]
id: GO:0102257
name: obsolete 1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O = 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of phospholipase A1 activity ; GO:0008970.
is_obsolete: true
replaced_by: GO:0008970

[Term]
id: GO:0102258
name: obsolete 1,3-diacylglycerol acylhydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid." [GOC:pz, PMID:21477884]
comment: This term was obsoleted because it represents the same activity as diacylglycerol lipase activity ; GO:0120516.
is_obsolete: true
replaced_by: GO:0120516

[Term]
id: GO:0102259
name: obsolete 1,2-diacylglycerol acylhydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid." [GOC:pz, PMID:1477884]
comment: This term was obsoleted because it represents the same activity as diacylglycerol lipase activity ; GO:0120516.
is_obsolete: true
replaced_by: GO:0120516

[Term]
id: GO:0102261
name: 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H+ + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)." [PMID:11726492, RHEA:31363]
synonym: "F420-dependent NADP reductase activity" BROAD []
xref: EC:1.5.1.40
xref: MetaCyc:RXN-12450
xref: RHEA:31363
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102262
name: tRNA-dihydrouridine16 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H." [GOC:pz]
xref: MetaCyc:RXN-12454
is_a: GO:0017150 ! tRNA dihydrouridine synthase activity

[Term]
id: GO:0102263
name: tRNA-dihydrouridine17 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) = H+ + a uracil17 in tRNA + NAD(P)H." [GOC:pz]
xref: MetaCyc:RXN-12455
is_a: GO:0017150 ! tRNA dihydrouridine synthase activity

[Term]
id: GO:0102264
name: tRNA-dihydrouridine20 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) = H+ + a uracil20 in tRNA + NAD(P)H." [EC:1.3.1.91, GOC:pz]
xref: EC:1.3.1.91
xref: MetaCyc:RXN-12456
is_a: GO:0017150 ! tRNA dihydrouridine synthase activity

[Term]
id: GO:0102265
name: tRNA-dihydrouridine47 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H." [EC:1.3.1.89, GOC:pz]
xref: EC:1.3.1.89
xref: MetaCyc:RXN-12457
is_a: GO:0017150 ! tRNA dihydrouridine synthase activity

[Term]
id: GO:0102266
name: tRNA-dihydrouridine20a synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H." [GOC:pz]
xref: EC:1.3.1.90
is_a: GO:0017150 ! tRNA dihydrouridine synthase activity

[Term]
id: GO:0102267
name: tRNA-dihydrouridine20b synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H." [GOC:pz]
xref: MetaCyc:RXN-12476
is_a: GO:0017150 ! tRNA dihydrouridine synthase activity

[Term]
id: GO:0102272
name: obsolete homophytochelatin synthase activity (polymer-forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102273
name: obsolete homophytochelatin synthase (dimmer forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate = gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102274
name: glutathione S-conjugate carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an S-substituted glutathione + H2O = glycine + S-substituted gamma-glutamyl-L-cysteine. Patricipates in glutathione-mediated detoxification." [RHEA:60448]
xref: EC:3.4.17.25
xref: MetaCyc:RXN-12532
xref: RHEA:60448
is_a: GO:0004181 ! metallocarboxypeptidase activity

[Term]
id: GO:0102275
name: obsolete cysteine-S-conjugate N-malonyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate = coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102276
name: 2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ = ethene + 3 carbon dioxide + H2O." [EC:1.13.12.19, GOC:pz]
xref: EC:1.13.12.19
xref: MetaCyc:RXN-12538
xref: RHEA:31523
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0102277
name: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine." [RHEA:62164]
xref: MetaCyc:RXN-12544
xref: RHEA:62164
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102278
name: obsolete N,N'-diacetylchitobiose synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: n H2O + chitin = N,N'-diacetylchitobiose." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102279
name: obsolete lecithin:11-cis retinol acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine = a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as phosphatidylcholine-retinol O-acyltransferase activity ; GO:0047173.
is_obsolete: true
replaced_by: GO:0047173

[Term]
id: GO:0102280
name: choline monooxygenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + NADP+ = betaine aldehyde + NADPH + H+." [GOC:pz, PMID:21769646]
synonym: "choline monooxygenase activity (NADP-dependent)" EXACT []
xref: MetaCyc:RXN-12582
is_a: GO:0008812 ! choline dehydrogenase activity

[Term]
id: GO:0102281
name: obsolete formylaminopyrimidine deformylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: formylaminopyrimidine + H2O = 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102282
name: obsolete 3-ketodihydrosphinganine (C18) reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD(1-) + a sphinganine = 3-dehydrosphinganinium(1+) + NADH + H+." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this reaction exists.
is_obsolete: true
replaced_by: GO:0016616

[Term]
id: GO:0102283
name: obsolete 3-ketodihydrosphinganine (C20) reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: C20 sphinganine(1+) + NADP = C20 3-dehydrosphinganine(1+) + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-dehydrosphinganine reductase activity; GO:0047560.
is_obsolete: true
replaced_by: GO:0047560

[Term]
id: GO:0102284
name: obsolete L-threo-sphinganine reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-threo-sphinganine + NADP = H+ + NADPH + 3-dehydrosphinganinium(1+)." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-dehydrosphinganine reductase activity; GO:0047560.
is_obsolete: true
replaced_by: GO:0047560

[Term]
id: GO:0102285
name: 1-deoxy-11-oxopentalenate oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP." [GOC:pz, RHEA:34635]
xref: EC:1.14.13.170
xref: MetaCyc:RXN-12654
xref: RHEA:34635
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102286
name: obsolete ornithine N-delta-acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102287
name: obsolete 4-coumaroylhexanoylmethane synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O = 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102289
name: beta-amyrin 11-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ = 11-oxo-beta-amyrin + 3 H2O + 2 NADP." [RHEA:31711]
xref: EC:1.14.14.152
xref: MetaCyc:RXN-12680
xref: RHEA:31711
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102290
name: obsolete beta-amyrin monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ = 11alpha-hydroxy-beta-amyrin + H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is a subreaction of beta-amyrin 11-oxidase activity ; GO:0102289.
is_obsolete: true
replaced_by: GO:0102289

[Term]
id: GO:0102291
name: obsolete 11alpha-hydroxy-beta-amyrin dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is a subreaction of beta-amyrin 11-oxidase activity ; GO:0102289.
is_obsolete: true
replaced_by: GO:0102289

[Term]
id: GO:0102292
name: obsolete 30-hydroxy-beta-amyrin 11-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102293
name: obsolete pheophytinase b activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pheophytin b + H2O = H+ + pheophorbide b + phytol." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of chlorophyllase activity GO:0047746.
is_obsolete: true
replaced_by: GO:0047746

[Term]
id: GO:0102294
name: cholesterol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NAD+ = cholest-5-en-3-one + NADH + H+." [RHEA:35459]
xref: MetaCyc:RXN-12693
xref: RHEA:35459
is_a: GO:0003854 ! 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity

[Term]
id: GO:0102295
name: obsolete 4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA = 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102296
name: 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+." [GOC:pz, RHEA:32035]
xref: EC:3.7.1.17
xref: MetaCyc:RXN-12718
xref: RHEA:32035
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0102297
name: obsolete selenate adenylyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: selenic acid + ATP + 2 H+ = adenylyl selenate + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102298
name: obsolete selenocystathione synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102299
name: linolenate 9R-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate. Also converts linoleate to (9R,10E,12Z)-9- hydroperoxyoctadeca-10,12-dienoate." [EC:1.13.11.61]
xref: EC:1.13.11.61
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102300
name: obsolete linoleate 9R-lipoxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate 9R-lipoxygenase activity ; GO:0102299.
is_obsolete: true
replaced_by: GO:0102299

[Term]
id: GO:0102301
name: obsolete gamma-linolenate elongase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102302
name: mycinamicin VI 2''-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+." [EC:2.1.1.238, GOC:pz]
xref: EC:2.1.1.238
xref: MetaCyc:RXN-12801
xref: RHEA:31643
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102303
name: resveratrol 3,5-O-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+." [EC:2.1.1.240, GOC:pz]
xref: EC:2.1.1.240
xref: MetaCyc:RXN-12805
xref: RHEA:32103
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102304
name: sesquithujene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = 7-epi-sesquithujene + diphosphoric acid." [EC:4.2.3.102, GOC:pz]
xref: EC:4.2.3.102
xref: MetaCyc:RXN-12838
xref: RHEA:31991
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102305
name: (13E)-labda-7,13-dien-15-ol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate." [RHEA:32075]
xref: EC:3.1.7.10
xref: MetaCyc:RXN-12892
xref: RHEA:32075
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0102306
name: benzil reductase [(S)-benzoin-forming] activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-benzoin + NADP(3-) = benzil + NADPH(4-) + H+." [EC:1.1.1.320, GOC:pz]
xref: EC:1.1.1.320
xref: MetaCyc:RXN-12898
xref: RHEA:25968
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102307
name: erythromycin 3''-o-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythromycin C + S-adenosyl-L-methionine = erythromycin A + H+ + S-adenosyl-L-homocysteine. Also converts erythromycin D into erythromycin B." [EC:2.1.1.254]
synonym: "erythromycin C 3''-o-methyltransferase activity" NARROW []
synonym: "erythromycin D 3''-o-methyltransferase activity" NARROW []
xref: EC:2.1.1.254
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102308
name: obsolete erythromycin D 3''-o-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of erythromycin 3''-o-methyltransferase activity; GO:0102307.
is_obsolete: true
replaced_by: GO:0102307

[Term]
id: GO:0102309
name: obsolete dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dTDP-D-oliose + NADP = dTDP-4-dehydro-2,6-dideoxy-D-glucose + NADPH + H+." [GOC:pz, PMID:21960454]
comment: This term was obsoleted because it does not represent a natural substrate.
is_obsolete: true

[Term]
id: GO:0102310
name: dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) = dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H." [EC:1.17.1.-, GOC:pz]
xref: MetaCyc:RXN-12940
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0102311
name: 8-hydroxygeraniol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP = (6E)-8-oxogeranial + 2 NADPH + 2 H+." [EC:1.1.1.324, GOC:pz]
xref: EC:1.1.1.324
xref: MetaCyc:RXN-12961
xref: RHEA:32659
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102312
name: 4-coumaroyl 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 = 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide." [GOC:pz, PMID:22168819, PMID:22169019]
xref: EC:1.14.11.62
xref: MetaCyc:RXN-12963
xref: RHEA:57868
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0102313
name: 1,8-cineole synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid." [GOC:pz, RHEA:32543]
xref: EC:4.2.3.108
xref: MetaCyc:RXN-12980
xref: RHEA:32543
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102317
name: 4-methylaminobutyrate oxidase (demethylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O = gamma-aminobutyric acid + formaldehyde + hydrogen peroxide." [EC:1.5.3.19, GOC:pz]
xref: EC:1.5.3.19
xref: MetaCyc:RXN-13067
xref: RHEA:33907
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0102318
name: 2-deoxystreptamine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+." [EC:2.4.1.284, GOC:pz]
xref: EC:2.4.1.284
xref: MetaCyc:RXN-13121
xref: RHEA:34063
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102319
name: 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine = H+ + 2'-N-acetylparomamine(2+) + UDP(3-)." [EC:2.4.1.283, GOC:pz]
xref: EC:2.4.1.283
xref: MetaCyc:RXN-13122
xref: RHEA:33947
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102320
name: 1,8-cineole 2-exo-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 = 2-exo-hydroxy-1,8-cineole + NADP + H2O." [GOC:pz, RHEA:32895]
xref: EC:1.14.14.56
xref: MetaCyc:RXN-4342
xref: RHEA:32895
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102321
name: obsolete 2,2'-hydroxybiphenyl monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ = biphenyl-2,2',3-triol + H2O + NAD." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as 2-hydroxybiphenyl 3-monooxygenase activity ; GO:0047544.
is_obsolete: true
replaced_by: GO:0047544

[Term]
id: GO:0102322
name: 2-propylphenol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD." [GOC:pz]
xref: MetaCyc:RXN-13151
xref: RHEA:63524
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102323
name: 2-isopropylphenol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD." [GOC:pz, RHEA:63520]
xref: MetaCyc:RXN-13152
xref: RHEA:63520
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102324
name: obsolete 2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity ; GO:0018774.
is_obsolete: true
replaced_by: GO:0018774

[Term]
id: GO:0102325
name: 2,2',3-trihydroxybiphenyl monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ = 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O." [GOC:pz, RHEA:63516]
xref: MetaCyc:RXN-13169
xref: RHEA:63516
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102326
name: obsolete 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O = 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity ; GO:0018774.
is_obsolete: true
replaced_by: GO:0018774

[Term]
id: GO:0102327
name: obsolete 3-oxoacyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiolester hydrolase activity ; GO:0016790.
is_obsolete: true
consider: GO:0016790

[Term]
id: GO:0102328
name: obsolete 3-oxoacid decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone." [GOC:pz]
comment: This term was obsoleted because it represents a the same activity as 3-oxolaurate decarboxylase activity ; GO:0050410.
is_obsolete: true
replaced_by: GO:0050410

[Term]
id: GO:0102329
name: obsolete hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 16-hydroxy-hentriaconta-3,6,9,12,19,22,25,28-octaene-15-oyl-CoA + NADP = hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this reaction exists.
is_obsolete: true

[Term]
id: GO:0102330
name: obsolete palmitoyl-[acp] elongase/decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102331
name: obsolete heptadecanoyl-[acp] elongase/decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102332
name: obsolete fatty-acyl-[acp] elongase/decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102333
name: obsolete stearoyl-[acp] elongase/decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102334
name: N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP." [EC:2.7.8.36, GOC:pz]
xref: EC:2.7.8.36
xref: MetaCyc:RXN-13269
xref: RHEA:34515
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0102335
name: N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine = N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+." [EC:2.4.1.290, GOC:pz]
xref: EC:2.4.1.290
xref: MetaCyc:RXN-13274
xref: RHEA:34511
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102336
name: obsolete 3-oxo-arachidoyl-CoA synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ = 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents an activity more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0009922

[Term]
id: GO:0102337
name: obsolete 3-oxo-cerotoyl-CoA synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ = 3-oxohexacosanoyl-CoA + carbon dioxide + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents an activity more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0009922

[Term]
id: GO:0102338
name: obsolete 3-oxo-lignoceronyl-CoA synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ = 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents an activity more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0009922

[Term]
id: GO:0102339
name: obsolete 3-oxo-arachidoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA(4-) + NADP(3-) = 3-oxoicosanoyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of very-long-chain 3-oxoacyl-CoA reductase activity ; GO:0141040.
is_obsolete: true
replaced_by: GO:0141040

[Term]
id: GO:0102340
name: obsolete 3-oxo-behenoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) = 3-oxodocosanoyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of very-long-chain 3-oxoacyl-CoA reductase activity ; GO:0141040.
is_obsolete: true
replaced_by: GO:0141040

[Term]
id: GO:0102341
name: obsolete 3-oxo-lignoceroyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA + NADP = 3-oxotetracosanoyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of very-long-chain 3-oxoacyl-CoA reductase activity ; GO:0141040.
is_obsolete: true
replaced_by: GO:0141040

[Term]
id: GO:0102342
name: obsolete 3-oxo-cerotoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA + NADP = 3-oxohexacosanoyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of very-long-chain 3-oxoacyl-CoA reductase activity ; GO:0141040.
is_obsolete: true
replaced_by: GO:0141040

[Term]
id: GO:0102343
name: obsolete 3-hydroxy-arachidoyl-CoA dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA = trans-2-icosenoyl-CoA + H2O." [EC:4.2.1.134, GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
is_obsolete: true
replaced_by: GO:0018812

[Term]
id: GO:0102344
name: obsolete 3-hydroxy-behenoyl-CoA dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA = trans-2-docosenoyl-CoA + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
is_obsolete: true
replaced_by: GO:0018812

[Term]
id: GO:0102345
name: obsolete 3-hydroxy-lignoceroyl-CoA dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA(4-) = trans-2-tetracosenoyl-CoA + H2O." [EC:4.2.1.134, GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
is_obsolete: true
replaced_by: GO:0018812

[Term]
id: GO:0102346
name: obsolete 3-hydroxy-cerotoyl-CoA dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA(4-) = trans-2-hexacosenoyl-CoA(4-) + H2O." [EC:4.2.1.134, GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
is_obsolete: true
replaced_by: GO:0018812

[Term]
id: GO:0102347
name: obsolete trans-arachidon-2-enoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: icosanoyl-CoA(4-) + NADP(3-) = trans-2-icosenoyl-CoA(4-) + NADPH(4-) + H+." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of very-long-chain enoyl-CoA reductase activity ; GO:0102758.
is_obsolete: true
replaced_by: GO:0102758

[Term]
id: GO:0102348
name: obsolete trans-docosan-2-enoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: behenoyl-CoA + NADP = trans-2-docosenoyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of very-long-chain enoyl-CoA reductase activity ; GO:0102758.
is_obsolete: true
replaced_by: GO:0102758

[Term]
id: GO:0102349
name: obsolete trans-lignocero-2-enoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tetracosanoyl-CoA + NADP = trans-2-tetracosenoyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of very-long-chain enoyl-CoA reductase activity ; GO:0102758.
is_obsolete: true
replaced_by: GO:0102758

[Term]
id: GO:0102350
name: obsolete trans-cerot-2-enoyl-CoA reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hexacosanoyl-CoA(4-) + NADP(3-) = trans-2-hexacosenoyl-CoA + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of very-long-chain enoyl-CoA reductase activity ; GO:0102758.
is_obsolete: true
replaced_by: GO:0102758

[Term]
id: GO:0102351
name: obsolete gamma-aminobutyrate transaminase (glyoxylate dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 4-aminobutyrate:pyruvate transaminase activity ; GO:0034387.
is_obsolete: true
replaced_by: GO:0034387

[Term]
id: GO:0102352
name: obsolete phosphatidate kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102354
name: 11-cis-retinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+." [GOC:pz, RHEA:54912]
xref: MetaCyc:RXN-13363
xref: RHEA:54912
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102355
name: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H+." [EC:3.1.1.91, GOC:pz]
xref: EC:3.1.1.91
xref: MetaCyc:RXN-13371
xref: RHEA:33967
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102356
name: obsolete isoitalicene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + (+)-isoitalicene." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102357
name: mithramycin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: mithramycin + NADP = mithramycin DK + NADPH + H+." [GOC:pz]
xref: MetaCyc:RXN-13385
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102358
name: daphnetin-8-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + H+ + S-adenosyl-L-homocysteine." [RHEA:68960]
xref: MetaCyc:RXN-13448
xref: RHEA:68960
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102359
name: obsolete daphnetin 4-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin = UDP + 4-O- beta -D-glucosyl-daphnetin + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of hydroxycinnamate 4-beta-glucosyltransferase activity ; GO:0047218.
is_obsolete: true
replaced_by: GO:0047218

[Term]
id: GO:0102360
name: obsolete daphnetin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin = UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of flavonol 3-O-glucosyltransferase activity ; GO:0047893.
is_obsolete: true
replaced_by: GO:0047893

[Term]
id: GO:0102361
name: obsolete esculetin 4-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 4-O-beta-D-glucosyl-esculetin + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of hydroxycinnamate 4-beta-glucosyltransferase activity ; GO:0047218.
is_obsolete: true
replaced_by: GO:0047218

[Term]
id: GO:0102362
name: obsolete esculetin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 3-O-beta-D-glucosyl-esculetin + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102363
name: obsolete isoscopoletin-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102365
name: taxoid 2alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O. Also converts 7beta-hydroxytaxusin to 2alpha,7beta-dihydroxytaxusin." [EC:1.14.14.183, PMID:15178487]
synonym: "taxusin 2-alpha-hydroxylase activity" EXACT []
xref: EC:1.14.14.183
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102366
name: obsolete 7-beta-hydroxytaxusin 2-alpha-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of taxoid 2alpha-hydroxylase activity ; GO:0102365.
is_obsolete: true
replaced_by: GO:0102365

[Term]
id: GO:0102367
name: obsolete 2-alpha-hydroxytaxusin 7-beta-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7beta-dihydroxytaxusin + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of taxoid 7beta-hydroxylase activity ; GO:0036239.
is_obsolete: true
replaced_by: GO:0036239

[Term]
id: GO:0102368
name: obsolete beta-amyrin 30-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 = 30-hydroxy-beta-amyrin + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102369
name: 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ = 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O." [GOC:pz]
xref: MetaCyc:RXN-13491
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0102370
name: obsolete lupeol 28-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ = betulin + NADP(3-) + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102371
name: obsolete betulin dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 = betulinic aldehyde + NADP(3-) + 2 H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102372
name: obsolete alpha-amyrin 28-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ = uvaol + NADP(3-) + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102373
name: beta-amyrin 28-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H+ + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]." [PMID:22039103, RHEA:43068]
synonym: "ursolic aldehyde 28-monooxygenase activity" RELATED []
synonym: "uvaol dehydrogenase activity" RELATED []
xref: EC:1.14.14.126
xref: KEGG_REACTION:R10924
xref: MetaCyc:RXN-13509
xref: RHEA:43068
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102374
name: obsolete ursolic aldehyde 28-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ = ursolic acid + NADP + H2O." [GOC:pz, PMID:22039103]
comment: This term was obsoleted because it represents the same activity as beta-amyrin 28-monooxygenase activity ; GO:0102373.
is_obsolete: true
replaced_by: GO:0102373

[Term]
id: GO:0102375
name: 11-oxo-beta-amyrin 30-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ = glycyrrhetinic acid + 3 NADP + 4 H2O." [GOC:pz, RHEA:35499]
xref: EC:1.14.14.115
xref: MetaCyc:RXN-13506
xref: RHEA:35499
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102376
name: obsolete lupeol 28-oxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ = betulinic acid + 3 NADP + 4 H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102377
name: steviol 13-O glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: steviol + UDP-alpha-D-glucose = H+ + steviolmonoside + UDP." [RHEA:61732]
xref: MetaCyc:RXN-13511
xref: RHEA:61732
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102378
name: steviolmonoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP." [RHEA:61736]
xref: MetaCyc:RXN-13512
xref: RHEA:61736
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102379
name: steviolbioside glucosyltransferase activity (stevioside forming)
namespace: molecular_function
def: "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP." [RHEA:61744]
xref: MetaCyc:RXN-13514
xref: RHEA:61744
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102380
name: steviolbioside glucosyltransferase activity (rebaudioside B forming)
namespace: molecular_function
def: "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = H+ + rebaudioside B + UDP." [RHEA:61752]
xref: MetaCyc:RXN-13516
xref: RHEA:61752
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102381
name: stevioside glucosyltransferase activity (rebaudioside A forming)
namespace: molecular_function
def: "Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = H+ + rebaudioside A + UDP." [RHEA:61756]
xref: MetaCyc:RXN-13517
xref: RHEA:61756
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102382
name: rebaudioside B glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP." [RHEA:61760]
xref: MetaCyc:RXN-13518
xref: RHEA:61760
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102383
name: obsolete steviol 19-O glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: steviol + UDP-alpha-D-glucose = 19-O-beta-glucopyranosyl-steviol + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102384
name: obsolete 19-O-beta-glucopyranosyl-steviol glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose = rubusoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102385
name: obsolete patchoulol synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = seychellene + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102386
name: phenylacetaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+." [GOC:pz, PMID:17644147]
xref: MetaCyc:RXN-13536
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102387
name: obsolete 2-phenylethanol acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of acetyl-coenzyme A:acetyl alcohol acetyltransferase activity ; GO:0102720.
is_obsolete: true
replaced_by: GO:0102720

[Term]
id: GO:0102388
name: UDP-N,N'-diacetylbacillosamine 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+." [EC:3.2.1.184, GOC:pz]
xref: EC:3.2.1.184
xref: MetaCyc:RXN-13574
xref: RHEA:34491
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102389
name: polyprenol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol." [GOC:pz, RHEA:34279]
xref: RHEA:34279
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102390
name: mycophenolic acid acyl-glucuronide esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O = mycophenolate + H+ + D-glucopyranuronate." [EC:3.1.1.93, GOC:pz]
xref: EC:3.1.1.93
xref: MetaCyc:RXN-13605
xref: RHEA:34179
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102391
name: decanoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA." [GOC:pz, RHEA:33627]
xref: MetaCyc:RXN-13614
xref: RHEA:33627
is_a: GO:0031956 ! medium-chain fatty acid-CoA ligase activity

[Term]
id: GO:0102392
name: obsolete decanoate-[HmqF protein] ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein = AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
consider: GO:0015645

[Term]
id: GO:0102393
name: obsolete decanoyl-[acp] 2-dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein = FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
replaced_by: GO:0003995

[Term]
id: GO:0102394
name: 4-hydroxy-L-isoleucine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD = (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+." [GOC:pz, PMID:21069315]
xref: MetaCyc:RXN-13637
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102395
name: 9-cis-beta-carotene 9',10'-cleavage oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone." [EC:1.13.11.68, GOC:pz]
xref: EC:1.13.11.68
xref: MetaCyc:RXN-13642
xref: RHEA:34399
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102396
name: 9-cis-10'-apo-beta-carotenal cleavage oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 = carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal." [EC:1.13.11.69, GOC:pz]
xref: EC:1.13.11.69
xref: MetaCyc:RXN-13643
xref: RHEA:34403
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102398
name: obsolete dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102399
name: obsolete dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102400
name: obsolete dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102402
name: obsolete 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of beta-primeverosidase activity ; GO:0050535.
is_obsolete: true
replaced_by: GO:0050535

[Term]
id: GO:0102404
name: obsolete linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O = vicianose + linalool." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of beta-primeverosidase activity ; GO:0050535.
is_obsolete: true
replaced_by: GO:0050535

[Term]
id: GO:0102405
name: (+)-taxifolin 5'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ = (+)-dihydromyricetin + NADP(3-) + H2O." [GOC:pz]
xref: MetaCyc:RXN-13718
xref: RHEA:61116
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102406
name: omega-hydroxypalmitate O-sinapoyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate = coenzyme A + 16-sinapoyloxypalmitate." [EC:2.3.1.188, GOC:pz]
xref: EC:2.3.1.188
xref: MetaCyc:RXN-13728
xref: RHEA:26470
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102407
name: obsolete sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: C22:0-DCA-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-C22:0-DCA-LPA." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of glycerol-3-phosphate 2-O-acyltransferase activity ; GO:0090447.
is_obsolete: true
replaced_by: GO:0090447

[Term]
id: GO:0102408
name: obsolete sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + sn-2-C16:0-DCA-LPA." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of glycerol-3-phosphate 2-O-acyltransferase activity ; GO:0090447.
is_obsolete: true
replaced_by: GO:0090447

[Term]
id: GO:0102409
name: obsolete sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: behenoyl-CoA + sn-glycerol 3-phosphate(2-) = coenzyme A + 2-docosanoyl-glycerol 3-phosphate." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of glycerol-3-phosphate 2-O-acyltransferase activity ; GO:0090447.
is_obsolete: true
replaced_by: GO:0090447

[Term]
id: GO:0102410
name: obsolete quercetin-4',3-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-)." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102411
name: obsolete quercetin-3,4'-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-)." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102412
name: valerena-4,7(11)-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = valerena-4,7(11)-diene + diphosphoric acid." [EC:4.2.3.139, GOC:pz]
xref: EC:4.2.3.139
xref: MetaCyc:RXN-13769
xref: RHEA:34467
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102413
name: 6-O-methyl-deacetylisoipecoside beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O = 6-O-methyl-N-deacetylisoipecoside aglycon + D-glucose." [RHEA:78891]
xref: MetaCyc:RXN-13791
xref: RHEA:78891
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102414
name: obsolete quercetin-3-O-glucoside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin-3-gentiobioside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102415
name: obsolete quercetin gentiobioside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose = quercetin-3-gentiotrioside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102416
name: obsolete quercetin gentiotrioside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose = quercetin-3-gentiotetraside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102417
name: obsolete apigenin-7-O-glucoside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = apigenin-7-O-gentiobioside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102418
name: obsolete luteolin-7-O-glucoside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102419
name: obsolete sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA." [GOC:pz]
comment: This term was obsoleted because it corresponds to a specific substrate of glycerol-3-phosphate 2-O-acyltransferase activity ; GO:0090447.
is_obsolete: true
replaced_by: GO:0090447

[Term]
id: GO:0102420
name: obsolete sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of glycerol-3-phosphate O-acyltransferase activity ; GO:0004366.
is_obsolete: true
replaced_by: GO:0004366

[Term]
id: GO:0102421
name: obsolete curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotrioside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102422
name: obsolete curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotetraside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102423
name: (+)-sesaminol 2-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose = (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+." [GOC:pz, PMID:18248594, PMID:19561332]
xref: MetaCyc:RXN-13818
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102424
name: obsolete sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose = (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102425
name: obsolete myricetin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: myricetin + UDP-alpha-D-glucose = myricetin 3-O-beta-D-glucopyranoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of flavonol 3-O-glucosyltransferase activity ; GO:0047893.
is_obsolete: true
replaced_by: GO:0047893

[Term]
id: GO:0102426
name: obsolete myricetin-3-O-glucoside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose = myricetin 3-O-gentiobioside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102427
name: obsolete allocryptopine 6-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ = 6-hydroxy-allocryptopine + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102428
name: obsolete kaempferol-3-O-glucoside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose = kaempferol-3-gentiobioside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102429
name: obsolete genistein-3-O-glucoside 1,6-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: genistin + UDP-alpha-D-glucose = genistin 7-gentiobioside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102431
name: acyl-lipid omega-(9-4) desaturase activity
namespace: molecular_function
alt_id: GO:0102430
def: "Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid) and add a fourth double bond (a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid)." [EC:1.14.19.12]
synonym: "acyl-lipid omega-(9-4) desaturase" EXACT []
synonym: "alpha-linolenate delta5 desaturase activity" NARROW []
synonym: "linoleate delta5 desaturase activity" RELATED []
xref: EC:1.14.19.12
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102432
name: quercetin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin + S-adenosyl-L-methionine = H+ + rhamnetin + S-adenosyl-L-homocysteine." [RHEA:73115]
xref: MetaCyc:RXN-13906
xref: RHEA:73115
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102433
name: obsolete phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate = L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as phenylalanine 4-monooxygenase activity ; GO:0004505.
is_obsolete: true
replaced_by: GO:0004505

[Term]
id: GO:0102434
name: pterin-4alpha-carbinolamine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate." [GOC:pz, PMID:18245455, PMID:20959559]
xref: MetaCyc:RXN-13908
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0102435
name: myricetin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myricetin + S-adenosyl-L-methionine = 7-O-methylmyricetin + H+ + S-adenosyl-L-homocysteine." [RHEA:74719]
xref: MetaCyc:RXN-13910
xref: RHEA:74719
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102436
name: obsolete 7-methylmyricetin 4'-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine = 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102438
name: obsolete laricitrin 4'-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine = H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102439
name: 3',4',5'-trimethylmyricetin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine." [RHEA:74739]
xref: MetaCyc:RXN-13916
xref: RHEA:74739
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102440
name: 3',4',5'-trimethylmyricetin 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine." [RHEA:74771]
xref: MetaCyc:RXN-13918
xref: RHEA:74771
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102441
name: syringetin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + syringetin = 7,3',5'-O-trimethylmyricetin + H+ + S-adenosyl-L-homocysteine." [RHEA:74735]
xref: MetaCyc:RXN-13919
xref: RHEA:74735
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102442
name: syringetin 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + syringetin = 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine." [RHEA:74767]
xref: MetaCyc:RXN-13920
xref: RHEA:74767
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102443
name: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate = NADH(2-) + H+ + a 2-oxo carboxylate." [EC:1.1.1.337, GOC:pz]
xref: EC:1.1.1.337
xref: MetaCyc:RXN-13927
xref: RHEA:34555
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102444
name: isorhamnetin 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H+ + S-adenosyl-L-homocysteine." [RHEA:74759]
xref: MetaCyc:RXN-13929
xref: RHEA:74759
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102445
name: 3-methylquercetin 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H+ + S-adenosyl-L-homocysteine." [RHEA:74715]
xref: MetaCyc:RXN-13930
xref: RHEA:74715
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102446
name: rhamnetin 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H+ + S-adenosyl-L-homocysteine." [RHEA:74763]
xref: MetaCyc:RXN-13932
xref: RHEA:74763
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102447
name: rhamnetin 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = H+ + rhamnacene + S-adenosyl-L-homocysteine." [RHEA:73271]
xref: MetaCyc:RXN-13933
xref: RHEA:73271
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102448
name: rhamnetin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 7,4'-O-dimethylquercetin + H+ + S-adenosyl-L-homocysteine." [RHEA:74731]
xref: MetaCyc:RXN-13934
xref: RHEA:74731
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102449
name: kaempferol 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: kaempferol + S-adenosyl-L-methionine = 3-O-methylkaempferol + H+ + S-adenosyl-L-homocysteine." [RHEA:74743]
xref: MetaCyc:RXN-13935
xref: RHEA:74743
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102450
name: kaempferide 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine = 7,4'-O-dimethylkaempferol + H+ + S-adenosyl-L-homocysteine." [RHEA:74775]
xref: MetaCyc:RXN-13936
xref: RHEA:74775
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102451
name: kaempferide 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine = 3,4'-O-dimethylkaempferol + H+ + S-adenosyl-L-homocysteine." [RHEA:74755]
xref: MetaCyc:RXN-13937
xref: RHEA:74755
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102452
name: bisdemethoxycurcumin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ = 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide." [EC:2.3.1.211, GOC:pz]
xref: EC:2.3.1.211
xref: MetaCyc:RXN-13958
xref: RHEA:34803
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102453
name: anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]." [GOC:pz, RHEA:35411]
xref: EC:2.3.1.215
xref: MetaCyc:RXN-13959
xref: RHEA:35411
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102454
name: cyanidin 3-O-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP." [RHEA:35631]
xref: EC:2.4.1.294
xref: MetaCyc:RXN-13960
xref: RHEA:35631
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102455
name: anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside." [GOC:pz, RHEA:35419]
xref: EC:2.4.1.297
xref: MetaCyc:RXN-13965
xref: RHEA:35419
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102456
name: obsolete cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose = cyanin betaine + trans-sinapate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific acyl-glucose donor for cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity ; \nGO:0102506.
is_obsolete: true
replaced_by: GO:0102506

[Term]
id: GO:0102457
name: cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,7-di-O-beta-D-glucoside + vanillate." [RHEA:35431]
synonym: "cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity" RELATED []
xref: EC:2.4.1.300
xref: MetaCyc:RXN-13969
xref: RHEA:35431
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102458
name: obsolete cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose = cyanin betaine + vanillate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific acyl-glucose donor for cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity ; \nGO:0102506.
is_obsolete: true
replaced_by: GO:0102506

[Term]
id: GO:0102459
name: 8-oxo-dADP diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+." [GOC:pz]
synonym: "8-oxo-deoxyadenine diphosphate phosphatase activity" EXACT []
xref: MetaCyc:RXN-14005
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:0102460
name: obsolete kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102461
name: obsolete kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102462
name: obsolete quercetin 3-sophoroside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102463
name: obsolete quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose = quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102464
name: zeaxanthin 2-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ = caloxanthin + H2O + NAD." [GOC:pz, PMID:22509387]
xref: MetaCyc:RXN-14016
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102465
name: zeaxanthin 2,2'-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 = nostoxanthin + 2 NAD + 2 H2O." [GOC:pz]
xref: MetaCyc:RXN-14018
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102466
name: obsolete beta-carotene 2,2'-beta-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102467
name: scutellarein 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP." [RHEA:28318]
xref: MetaCyc:RXN-14058
xref: RHEA:28318
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102468
name: wogonin 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate + H+." [RHEA:28322]
xref: MetaCyc:RXN-14060
xref: RHEA:28322
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102469
name: naringenin 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction:(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:57588]
xref: MetaCyc:RXN-14069
xref: RHEA:57588
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102470
name: obsolete 6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose = 6C-glucosyl-2-hydroxynaringenin + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-hydroxyflavanone C-glucosyltransferase activity ; GO:0120514.
is_obsolete: true
replaced_by: GO:0120514

[Term]
id: GO:0102471
name: obsolete 2-hydroxynaringenin-6C-glucoside dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin = isovitexin-7-olate + H2O." [GOC:pz]
comment: This reaction was obsoleted because the enzyme catalyzing that reaction has not been characterized, see MetaCyc:RXN-14076.
is_obsolete: true

[Term]
id: GO:0102472
name: obsolete eriodictyol 2-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ = 2-hydroxyeriodictyol + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of flavanone 2-hydroxylase activity ; GO:0033771.
is_obsolete: true
replaced_by: GO:0033771

[Term]
id: GO:0102473
name: obsolete eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-hydroxyflavanone C-glucosyltransferase activity ; GO:0120514.
is_obsolete: true
replaced_by: GO:0120514

[Term]
id: GO:0102474
name: obsolete eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-hydroxyflavanone C-glucosyltransferase activity ; GO:0120514.
is_obsolete: true
replaced_by: GO:0120514

[Term]
id: GO:0102475
name: obsolete 2-hydroxyeriodictyol 6C-glucoside dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol = isoorientin + H2O." [GOC:pz]
comment: This reaction was obsoleted because the enzyme catalyzing that reaction has not been characterized, see MetaCyc:RXN-14081.
is_obsolete: true

[Term]
id: GO:0102476
name: obsolete pinocembrin 2-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ = 2,5,7-trihydroxyflavanone + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102477
name: obsolete 2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone = H+ + 6C-hexosyl chrysin + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-hydroxyflavanone C-glucosyltransferase ; GO:0120514.
is_obsolete: true
consider: GO:0120514

[Term]
id: GO:0102478
name: beta-L-arabinofuranosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose." [GOC:pz, RHEA:36051]
xref: EC:3.2.1.185
xref: MetaCyc:RXN-14089
xref: RHEA:36051
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102479
name: obsolete quercetin 3-O-beta:-D-galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose = quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of kaempferol 3-O-galactosyltransferase activity ;  GO:0033834.
is_obsolete: true
replaced_by: GO:0033834

[Term]
id: GO:0102480
name: obsolete 5-fluorocytosine deaminase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + flucytosine + H2O = 5-fluorouracil + ammonium." [GOC:pz]
comment: This term was obsoleted because it doesn't represent a physiological substrate.
is_obsolete: true
consider: GO:0004131

[Term]
id: GO:0102481
name: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H+." [GOC:pz, RHEA:25836]
xref: EC:3.7.1.22
xref: MetaCyc:RXN-14149
xref: RHEA:25836
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0102482
name: 5-deoxy-D-glucuronate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate." [GOC:pz, RHEA:25840]
xref: EC:5.3.1.30
xref: MetaCyc:RXN-14150
xref: RHEA:25840
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0102483
name: obsolete scopolin beta-glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + scopolin = beta-D-glucose + scopoletin." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of beta-glucosidase activity ; GO:0008422.
is_obsolete: true
consider: GO:0008422

[Term]
id: GO:0102484
name: obsolete esculetin glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) = esculin + UDP(3-) + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102485
name: obsolete dATP phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dATP + 2 H2O = dAMP + 2 hydrogenphosphate + 2 H+." [GOC:pz]
comment: This term has been obsoleted because it represents two molecular functions, 'nucleoside diphosphate phosphatase activity' and 'nucleoside triphosphate phosphatase activity'.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0102486
name: obsolete dCTP phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dCTP + 2 H2O = dCMP + 2 hydrogenphosphate + 2 H+." [GOC:pz]
comment: This term has been obsoleted because it represents two molecular functions, 'nucleoside diphosphate phosphatase activity' and 'nucleoside triphosphate phosphatase activity'.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0102487
name: obsolete dUTP phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dUTP + 2 H2O = dUMP + 2 hydrogenphosphate + 2 H+." [GOC:pz]
comment: This term has been obsoleted because it represents two molecular functions, 'nucleoside diphosphate phosphatase activity' and 'nucleoside triphosphate phosphatase activity'.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0102488
name: obsolete dTTP phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dTTP + 2 H2O = dTMP + 2 hydrogenphosphate + 2 H+." [GOC:pz]
comment: This term has been obsoleted because it represents two molecular functions, 'nucleoside diphosphate phosphatase activity' and 'nucleoside triphosphate phosphatase activity'.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0102489
name: obsolete GTP phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + 2 H2O = GMP + 2 hydrogenphosphate + 2 H+." [GOC:pz]
comment: This term has been obsoleted because it represents two molecular functions, 'nucleoside diphosphate phosphatase activity' and 'nucleoside triphosphate phosphatase activity'.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0102490
name: obsolete 8-oxo-dGTP phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 hydrogenphosphate + 2 H+." [GOC:pz]
comment: This term has been obsoleted because it represents two molecular functions, 'nucleoside diphosphate phosphatase activity' and 'ribonucleoside triphosphate phosphatase activity'.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0102491
name: obsolete dGTP phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dGTP + 2 H2O = dGMP + 2 hydrogenphosphate + 2 H+." [GOC:pz]
comment: This term has been obsoleted because it represents two molecular functions, 'nucleoside diphosphate phosphatase activity' and 'nucleoside triphosphate phosphatase activity'.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0102493
name: obsolete wogonin 7-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: wogonin + UDP-alpha-D-glucose = wogonin 7-O-beta-D-glucoside + UDP + H+." [GOC:pz, PMID:10872235]
comment: This term was obsoleted because it represents a specific substrate of flavonol 7-O-beta-glucosyltransferase activity ; GO:0033836.
is_obsolete: true
replaced_by: GO:0033836

[Term]
id: GO:0102494
name: obsolete GA20 2,3-desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor = gibberellin A5 + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102495
name: obsolete GA5 3beta-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A3 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102496
name: obsolete GA5 2,3 epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A6 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102497
name: scyllo-inositol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: scyllo-inositol + NADP = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+." [EC:1.1.1.371, GOC:pz]
xref: EC:1.1.1.371
xref: MetaCyc:RXN-14347
xref: RHEA:39063
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102498
name: obsolete maltose glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + maltose = 2 glucose." [GOC:pz, PMID:16343940]
comment: This term was obsoleted because it represents a specific substrate of alpha-1,4-glucosidase activity ; GO:0004558.
is_obsolete: true
replaced_by: GO:0004558

[Term]
id: GO:0102499
name: obsolete SHG alpha-glucan phosphorylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 1,4-alpha-oligoglucan phosphorylase activity ; GO:0004645.
is_obsolete: true
replaced_by: GO:0004645

[Term]
id: GO:0102500
name: obsolete beta-maltose 4-alpha-glucanotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 4-alpha-glucanotransferase activity ; GO:0004134.
is_obsolete: true
replaced_by: GO:0004134

[Term]
id: GO:0102501
name: D-fructuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate." [GOC:pz, PMID:22925190]
xref: MetaCyc:RXN-14368
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102502
name: obsolete ADP-glucose-starch glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose." [GOC:pz]
comment: The reason for obsoletion is that this term is equivalent to GO:0033840 NDP-glucose-starch glucosyltransferase activity.
is_obsolete: true
replaced_by: GO:0033840

[Term]
id: GO:0102504
name: obsolete luteolinidin 5-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose = luteolinidin 5-O-glucoside + UDP + 2 H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102505
name: obsolete apigeninidin 5-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose = apigeninidin 5-O-glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102506
name: cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose) activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+." [RHEA:35427]
xref: EC:2.4.1.299
xref: KEGG_REACTION:R10261
xref: MetaCyc:RXN-13967
xref: RHEA:35427
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102507
name: obsolete cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity ; GO:0102457.
is_obsolete: true
replaced_by: GO:0102457

[Term]
id: GO:0102508
name: obsolete cyanidin 3,7-diglucoside glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O = cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102509
name: obsolete cyanidin 3,5-diglucoside glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanin betaine + H2O = cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102510
name: obsolete pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity ; \nGO:0102506.
is_obsolete: true
replaced_by: GO:0102506

[Term]
id: GO:0102511
name: obsolete pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity ; GO:0102457.
is_obsolete: true
replaced_by: GO:0102457

[Term]
id: GO:0102512
name: obsolete delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity ; \nGO:0102506.
is_obsolete: true
replaced_by: GO:0102506

[Term]
id: GO:0102513
name: obsolete delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity ; GO:0102457.
is_obsolete: true
replaced_by: GO:0102457

[Term]
id: GO:0102514
name: obsolete cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity ; GO:0102457.
is_obsolete: true
replaced_by: GO:0102457

[Term]
id: GO:0102515
name: obsolete pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity ; GO:0102457.
is_obsolete: true
replaced_by: GO:0102457

[Term]
id: GO:0102516
name: obsolete delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity ; GO:0102457.
is_obsolete: true
replaced_by: GO:0102457

[Term]
id: GO:0102517
name: oleate 12-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + acceptor + H2O." [RHEA:55956]
xref: MetaCyc:RXN-14487
xref: RHEA:55956
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102518
name: obsolete (11Z)-eicosenoate 14-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O." [GOC:pz, PMID:8784737, PMID:9680976]
comment: This term was obsoleted because it represents a specific substrate of phosphatidylcholine 12-monooxygenase activity ; GO:0050183.
is_obsolete: true
replaced_by: GO:0050183

[Term]
id: GO:0102520
name: obsolete L-threonine O-3-phosphate phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102521
name: tRNA-4-demethylwyosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe." [GOC:pz, PMID:34184886, RHEA:36347]
xref: EC:4.1.3.44
xref: MetaCyc:RXN-14516
xref: RHEA:36347
is_a: GO:0016833 ! oxo-acid-lyase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0102522
name: tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe = 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe." [EC:2.5.1.114, GOC:pz]
xref: EC:2.5.1.114
xref: MetaCyc:RXN-14518
xref: RHEA:36355
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0102523
name: 2-chloroacrylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-chloropropanoate + NADP = 2-chloroacrylate + NADPH + H+." [EC:1.3.1.103, GOC:pz]
xref: EC:1.3.1.103
xref: MetaCyc:RXN-14536
xref: RHEA:36591
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102524
name: tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe." [GOC:pz, RHEA:37899]
synonym: "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity" EXACT []
xref: EC:1.14.11.42
xref: MetaCyc:RXN-14538
xref: RHEA:37899
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0102525
name: 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide." [GOC:pz, RHEA:36607]
xref: EC:1.14.11.41
xref: MetaCyc:RXN-14542
xref: RHEA:36607
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0102526
name: 8-demethylnovobiocic acid C8-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid + H+." [EC:2.1.1.284, GOC:pz]
xref: EC:2.1.1.284
xref: MetaCyc:RXN-14543
xref: RHEA:36651
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102527
name: 8-demethylnovobiocate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) = H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid." [EC:6.3.1.15, GOC:pz]
xref: EC:6.3.1.15
xref: MetaCyc:RXN-14547
xref: RHEA:36699
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0102528
name: obsolete 7,8,4'-trihydroxyflavone methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone = H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102529
name: apigenin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: apigenin + S-adenosyl-L-methionine = genkwanin + H+ + S-adenosyl-L-homocysteine." [RHEA:73071]
xref: MetaCyc:RXN-14661
xref: RHEA:73071
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102530
name: aclacinomycin T methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: aclacinomycin T(1+) + H2O = 15-demethylaclacinomycin T + methanol + H+." [EC:3.1.1.95, GOC:pz]
xref: EC:3.1.1.95
xref: MetaCyc:RXN-14703
xref: RHEA:37891
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102531
name: ecdysteroid-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = phosphate + an ecdysteroid. Also has activity towards other ecdysteriod phosphates including 20-hydroxyecdysone 22-phosphate (20E22P) and 2-deoxyecdysone 22-phosphate (2dE22P)." [MetaCyc:RXN-14734, PMID:12721294]
synonym: "ecdysone-phosphate phosphatase activity" NARROW []
xref: MetaCyc:RXN-14734
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0102532
name: genkwanin 6-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: genkwanin + O2 + reduced [NADPH--hemoprotein reductase] = H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether." [RHEA:73427]
xref: MetaCyc:RXN-14748
xref: RHEA:73427
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102533
name: genkwanin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine." [RHEA:73263]
xref: MetaCyc:RXN-14750
xref: RHEA:73263
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102534
name: apigenin-7,4'-dimethyl ether 6-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]." [RHEA:73435]
xref: MetaCyc:RXN-14751
xref: RHEA:73435
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102535
name: ladanein 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ladanein + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + salvigenin." [RHEA:73247]
xref: MetaCyc:RXN-14752
xref: RHEA:73247
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102536
name: sakuranetin 6-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:23184958, RHEA:73431]
xref: MetaCyc:RXN-14754
xref: RHEA:73431
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102537
name: obsolete ecdysone-phosphate phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ecdysone 22-phosphate + H2O = ecdysone + hydrogenphosphate." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as ecdysteroid-phosphate phosphatase activity ; GO:0102531.
is_obsolete: true
replaced_by: GO:0102531

[Term]
id: GO:0102538
name: UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H." [GOC:pz, PMID:10627048, PMID:24817117]
xref: MetaCyc:RXN-14767
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102539
name: UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H." [GOC:pz, PMID:10627048]
xref: MetaCyc:RXN-14769
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102540
name: obsolete D-mannose 6-phosphate 1-epimerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102541
name: obsolete D-galactose 6-phosphate 1-epimerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102542
name: obsolete aclacinomycin A methylesterase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: aclacinomycin A + H2O = 15-demethoxy-aclacinomycin A + methanol + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aclacinomycin T methylesterase activity ; GO:0102530.
is_obsolete: true
replaced_by: GO:0102530

[Term]
id: GO:0102543
name: obsolete epsilon-rhodomycinone methylesterase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: epsilon-rhodomycinone + H2O = 15-demethoxy-epsilon-rhodomycinone + methanol + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aclacinomycin T methylesterase activity ; GO:0102530.
is_obsolete: true
replaced_by: GO:0102530

[Term]
id: GO:0102544
name: ornaline synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ = ornaline + NADP + H2O." [EC:1.5.1.-, GOC:pz]
xref: MetaCyc:RXN-14880
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102545
name: phosphatidyl phospholipase B activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate." [GOC:pz, MetaCyc:RXN-14899]
xref: MetaCyc:RXN-14899
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0102546
name: mannosylglycerate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose." [RHEA:58456]
xref: EC:3.2.1.170
xref: MetaCyc:RXN-14900
xref: RHEA:58456
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0102547
name: glucosylglycerate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O = (R)-glycerate + D-glucose." [RHEA:32059]
xref: EC:3.2.1.208
xref: MetaCyc:RXN-14901
xref: RHEA:32059
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0102549
name: obsolete 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O = sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of galactolipase activity ; GO:0047714.
is_obsolete: true
replaced_by: GO:0047714

[Term]
id: GO:0102550
name: 2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+." [EC:2.1.1.295, GOC:pz]
xref: EC:2.1.1.295
xref: MetaCyc:RXN-14917
xref: RHEA:38007
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102551
name: obsolete homogentisate geranylgeranyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + H+ + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate." [EC:2.5.1.116, GOC:pz]
comment: The reason for obsoletion is that this term is equivalent to GO:0010356 homogentisate geranylgeranyl transferase activity.
is_obsolete: true
replaced_by: GO:0010356

[Term]
id: GO:0102552
name: obsolete lipoyl synthase activity (acting on glycine-cleavage complex H protein
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
replaced_by: GO:0016992

[Term]
id: GO:0102553
name: obsolete lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
replaced_by: GO:0016992

[Term]
id: GO:0102554
name: obsolete lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
replaced_by: GO:0016992

[Term]
id: GO:0102556
name: dammarenediol 12-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 = (20S)-protopanaxadiol + NADP + H2O." [EC:1.14.14.120, GOC:pz]
xref: EC:1.14.14.120
xref: MetaCyc:RXN-14975
xref: RHEA:38579
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102557
name: protopanaxadiol 6-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [EC:1.14.14.121]
xref: EC:1.14.14.121
xref: MetaCyc:RXN-14978
xref: RHEA:22272
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102559
name: protein-(glutamine-N5) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine." [GOC:pz, RHEA:42896]
xref: EC:2.1.1.297
xref: MetaCyc:RXN-14992
xref: RHEA:42896
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102560
name: obsolete 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = D-ribofuranose 2,5-bisphosphate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of D-ribose 2,5-bisphosphate 2-phosphohydrolase activity ; GO:0102561.
synonym: "phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase" EXACT []
is_obsolete: true
replaced_by: GO:0102561

[Term]
id: GO:0102561
name: phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H+." [EC:3.1.4.57]
synonym: "cyclic phosphate dihydrolase activity" RELATED []
synonym: "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity" RELATED []
xref: EC:3.1.4.57
xref: MetaCyc:RXN-14996
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0102562
name: obsolete hydroxyproline O-arbinofuranose transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline." [GOC:pz]
comment: The reason for obsoletion is that this term is equivalent to GO:1990585 hydroxyproline O-arabinosyltransferase activity.
is_obsolete: true
replaced_by: GO:1990585

[Term]
id: GO:0102563
name: obsolete aurachin C monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H = aurachin C epoxide + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102564
name: obsolete aurachin C epoxide hydrolase/isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H = aurachin B + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102566
name: obsolete 1-acyl dihydroxyacetone phosphate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of acylglycerone-phosphate reductase activity ; GO:0000140.
is_obsolete: true
replaced_by: GO:0000140

[Term]
id: GO:0102569
name: obsolete FR-33289 synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 = FR-33289 + succinate(2-) + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102570
name: obsolete tyrosine:phenylpyruvate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102571
name: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl/L-threonyl-[protein] + H2O = L-seryl//L-threonyl-[protein] + N-acetyl-D-glucosamine." [EC:3.2.1.169]
xref: EC:3.2.1.169
xref: MetaCyc:RXN-15215
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0102572
name: N-glutamylanilide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+." [GOC:pz]
xref: MetaCyc:RXN-15251
xref: RHEA:50684
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0102573
name: aminodeoxyfutalosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O = aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+." [EC:2.5.1.120, GOC:pz]
xref: EC:2.5.1.120
xref: MetaCyc:RXN-15264
xref: RHEA:33075
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0102574
name: obsolete 3-oxo-myristoyl-ACP hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiolester hydrolase activity ; GO:0016790.
is_obsolete: true
consider: GO:0016790

[Term]
id: GO:0102575
name: obsolete 3-oxo-dodecanoyl-ACP hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiolester hydrolase activity ; GO:0016790.
is_obsolete: true
consider: GO:0016790

[Term]
id: GO:0102576
name: obsolete 3-oxo-palmitoyl-ACP hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiolester hydrolase activity ; GO:0016790.
is_obsolete: true
consider: GO:0016790

[Term]
id: GO:0102577
name: obsolete 3-oxo-palmitate decarboxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-oxolaurate decarboxylase activity ; GO:0050410.
is_obsolete: true
replaced_by: GO:0050410

[Term]
id: GO:0102580
name: cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose = cyanidin 3-O-beta-D-sambubioside + UDP." [EC:2.4.2.51, GOC:pz]
xref: EC:2.4.2.51
xref: MetaCyc:RXN-15326
xref: RHEA:35443
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0102581
name: obsolete cyanidin 3-O-glucoside-p-coumaroyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ = cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102582
name: obsolete cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose = cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102583
name: obsolete cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA = cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102584
name: obsolete cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose = cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+." [GOC:pz, PMID:15807784]
comment: This term was obsoleted because it represents a specific substrate of cyanidin 3-O-galactosyltransferase activity ; GO:0102454.
is_obsolete: true
replaced_by: GO:0102454

[Term]
id: GO:0102585
name: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanin A3 + malonyl-CoA = anthocyanin A5 + CoA." [PMID:17292360, RHEA:72871]
xref: MetaCyc:RXN-15331
xref: RHEA:72871
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102586
name: obsolete cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102587
name: obsolete cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102588
name: obsolete cyanidin 3-O-glucoside 6''-O-malonyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA = cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of anthocyanin 6''-O-malonyltransferase activity ; GO:0033809.
is_obsolete: true
replaced_by: GO:0033809

[Term]
id: GO:0102589
name: obsolete cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) = cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102590
name: obsolete delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose = delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102591
name: obsolete delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose = delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102592
name: obsolete delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose = violdelphin + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102593
name: obsolete UDP-glucose: N-methylanthranilate glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102594
name: obsolete cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102595
name: obsolete cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102596
name: cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 = ent-sandaracopimaradien-3beta-ol + NADP + H2O." [EC:1.14.14.70, GOC:pz]
xref: EC:1.14.14.70
xref: MetaCyc:RXN-15379
xref: RHEA:41464
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102597
name: 3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 = oryzalexin E + NADP + H2O." [EC:1.14.14.122, GOC:pz]
xref: EC:1.14.14.122
xref: MetaCyc:RXN-15381
xref: RHEA:41468
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102598
name: 3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 = oryzalexin D + NADP + H2O." [EC:1.14.14.123, GOC:pz]
xref: EC:1.14.14.123
xref: MetaCyc:RXN-15382
xref: RHEA:41472
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102599
name: obsolete cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-beta-amyrin + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102600
name: obsolete cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102601
name: beta-amyrin 16beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]." [EC:1.14.14.63]
synonym: "cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity" EXACT []
xref: EC:1.14.14.63
xref: MetaCyc:RXN-15385
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102602
name: obsolete cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102603
name: obsolete 12-demethyl-elloramycin C12a O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine = elloramycin + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102605
name: obsolete cyclooctat-9-en-5,7-diol C18-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ = cyclooctatin + H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102606
name: obsolete octat-9-en-7-ol 5-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ = cyclooctat-9-en-5,7-diol + H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102607
name: obsolete 3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ = 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102608
name: obsolete tetracenomycin B3 8-O-methyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine = tetracenomycin E + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102610
name: (+)-secoisolariciresinol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose = (+)-secoisolariciresinol monoglucoside + UDP + H+." [GOC:pz, PMID:24678929]
xref: MetaCyc:RXN-15442
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102611
name: (+)-secoisolariciresinol monoglucoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose = (+)-secoisolariciresinol diglucoside + UDP + H+." [GOC:pz, PMID:24678929]
xref: MetaCyc:RXN-15443
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102612
name: syn-pimaradiene 6beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ = 6beta-hydroxy-syn-pimaradiene + NADP + H2O." [GOC:pz, PMID:22215681]
xref: MetaCyc:RXN-15452
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102613
name: trimethyluric acid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ = 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O." [GOC:pz, RHEA:48992]
xref: MetaCyc:RXN-15454
xref: RHEA:48992
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102614
name: germacrene A acid 8beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:57964]
xref: EC:1.14.14.168
xref: MetaCyc:RXN-15460
xref: RHEA:57964
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102615
name: obsolete ent-cassadiene-C2-hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ = 2alpha-hydroxy-ent-cassadiene + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102616
name: obsolete oryzalexin A synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: oryzalexin D + NAD(P) = oryzalexin A + H+ + NAD(P)H." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ; GO:0016616.
is_obsolete: true
replaced_by: GO:0016616

[Term]
id: GO:0102617
name: obsolete oryzalexin C synthase (oryzalexin B dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: oryzalexin B + NAD(P) = oryzalexin C + H+ + NAD(P)H." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ; GO:0016616.
is_obsolete: true
replaced_by: GO:0016616

[Term]
id: GO:0102618
name: obsolete oryzalexin B synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: oryzalexin D + NAD(P) = oryzalexin B + H+ + NAD(P)H." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ; GO:0016616.
is_obsolete: true
replaced_by: GO:0016616

[Term]
id: GO:0102619
name: obsolete oryzalexin C synthase (oryzalexin A dependent) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: oryzalexin A + NAD(P) = oryzalexin C + H+ + NAD(P)H." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ; GO:0016616.
is_obsolete: true
replaced_by: GO:0016616

[Term]
id: GO:0102620
name: obsolete 3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102621
name: obsolete emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ = 14,15-epoxyemindole-SB + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102622
name: obsolete linuron hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: linuron + H2O = N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102623
name: scutellarein 7-methyl ether 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + scutellarein 7-methyl ether = cirsimaritin + H+ + S-adenosyl-L-homocysteine." [RHEA:73243]
xref: MetaCyc:RXN-15528
xref: RHEA:73243
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102624
name: scutellarein 7-methyl ether 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + scutellarein 7-methyl ether = H+ + ladanein + S-adenosyl-L-homocysteine." [RHEA:73239]
xref: MetaCyc:RXN-15529
xref: RHEA:73239
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102625
name: cirsimaritin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + salvigenin." [RHEA:73251]
xref: MetaCyc:RXN-15530
xref: RHEA:73251
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102626
name: parthenolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide." [RHEA:61320]
xref: MetaCyc:RXN-15531
xref: RHEA:61320
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102627
name: parthenolide 3beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + parthenolide + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyparthenolide + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:61328]
xref: MetaCyc:RXN-15532
xref: RHEA:61328
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102628
name: costunolide 3beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-costunolide (12,6alpha) + reduced [NADPH-hemoprotein reductase] + dioxygen = 3beta-hydroxycostunolide + oxidized [NADPH-hemoprotein reductase] + H2O." [MetaCyc:RXN-15533]
xref: MetaCyc:RXN-15533
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102629
name: obsolete patuletin 3'-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: patuletin + S-adenosyl-L-methionine = quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102630
name: obsolete gossypetin 8-methyl ester 3'-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine = gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102631
name: obsolete caffeoylglucose 3-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine = 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102632
name: (S)-nandinine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [GOC:pz, PMID:17250743, PMID:21094631, RHEA:50364]
xref: EC:1.14.19.73
xref: MetaCyc:RXN-15538
xref: RHEA:50364
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102633
name: obsolete flaviolin monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 = mompain + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102634
name: 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 = flaviolin-2-olate + H2O + H+." [GOC:pz, PMID:15701630]
xref: MetaCyc:RXN-15586
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0102635
name: 11-deoxycorticosterone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ = 4-pregnen-20,21-diol-3-one + NAD." [GOC:pz, HEA:47716]
xref: MetaCyc:RXN-15607
xref: RHEA:47716
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102636
name: obsolete 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine = 3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 5-oxo-L-prolinate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of gamma-glutamylcyclotransferase activity ; GO:0003839.
is_obsolete: true
replaced_by: GO:0003839

[Term]
id: GO:0102637
name: obsolete 5-aminolevulinate-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP = 5-aminolevulinyl-CoA + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true
replaced_by: GO:0016405

[Term]
id: GO:0102638
name: obsolete [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene \n5'-phosphate synthase ; GO:0102041.
is_obsolete: true
replaced_by: GO:0102041

[Term]
id: GO:0102639
name: obsolete paspalicine synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ = paspalicine + NADP + 2 H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102640
name: obsolete paspalinine synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: paspalicine + O2 + NADPH + H+ = paspalinine + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102641
name: (R)-lactaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-propane-1,2-diol + NADP = (R)-lactaldehyde + NADPH + H+." [GOC:pz]
xref: MetaCyc:RXN-15743
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102643
name: obsolete scalarane-17alpha-19-diol synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specifi substrate of squalene-hopene cyclase activity ; GO:0051007.
is_obsolete: true
replaced_by: GO:0051007

[Term]
id: GO:0102644
name: obsolete monocyclic sesterterpenediol synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: monocyclic sesterterpenediol = all-trans-geranylfarnesol + H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specifi substrate of squalene-hopene cyclase activity ; GO:0051007.
is_obsolete: true
consider: GO:0051007

[Term]
id: GO:0102645
name: 17(E)-cheilanthenediol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17(E)-cheilanthenediol = all-trans-geranylfarnesol + H2O." [GOC:pz, PMID:24200803]
xref: MetaCyc:RXN-15758
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0102646
name: 14betaH-scalarane-17alpha-19-diol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O." [GOC:pz, PMID:24200803]
xref: MetaCyc:RXN-15759
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0102647
name: obsolete D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate = D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102648
name: obsolete D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate = D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102649
name: obsolete acetoacetyl-ACP synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] = acetoacetyl-ACP + 2 coenzyme A + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102650
name: obsolete cyclo-acetoacetyl-L-tryptophan synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP = cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102652
name: obsolete gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 = gibberellin A51 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of gibberellin 3-beta-dioxygenase activity ; GO:0016707.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102653
name: obsolete gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 = H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0045543

[Term]
id: GO:0102654
name: palmitoyl-[glycerolipid] 3-(E)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]. The this activity introduces an unusual trans double bond at carbon 3 of a palmitoyl group attached to the sn-2 position of glycerolipids." [RHEA:46764]
synonym: "1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity" RELATED []
xref: EC:1.14.19.43
xref: MetaCyc:RXN-16053
xref: RHEA:46764
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102655
name: obsolete 1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102656
name: obsolete 1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific reaction of sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102657
name: obsolete 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15579662]
comment: This term was obsoleted because it represents the same reaction as palmitoyl-[glycerolipid] 7-desaturase activity ; GO:0102843.
is_obsolete: true
replaced_by: GO:0102843

[Term]
id: GO:0102658
name: obsolete 2-oxo-5-methylthiopentanoate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid = L-homomethionine + a 2-oxo carboxylate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102659
name: obsolete UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate = H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiohydroximate beta-D-glucosyltransferase activity ; GO:0047251.
is_obsolete: true
replaced_by: GO:0047251

[Term]
id: GO:0102660
name: obsolete caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: caffeoylshikimate + coenzyme A = caffeoyl-CoA + shikimate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102661
name: obsolete homogentisate solanyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ = 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid." [GOC:pz]
comment: The reason for obsoletion is that this term is equivalent to GO:0010357 homogentisate solanesyltransferase activity.
is_obsolete: true
replaced_by: GO:0010357

[Term]
id: GO:0102662
name: obsolete malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) = acetyl-CoA(4-) + carbon dioxide + NADH(2-)." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as GO:0018478 ; malonate-semialdehyde dehydrogenase (acetylating) activity.
is_obsolete: true
replaced_by: GO:0018478

[Term]
id: GO:0102663
name: obsolete gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 = H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0045543

[Term]
id: GO:0102664
name: obsolete indole-3-acetyl-leucine synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetate + L-leucine + ATP = H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102665
name: obsolete indole-3-acetyl-glutamate synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP = H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102666
name: obsolete indole-3-acetyl-beta-4-D-glucose hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O = H+ + indole-3-acetate + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102667
name: obsolete indole-3-acetyl-beta-1-D-glucose hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O = H+ + indole-3-acetate + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102669
name: obsolete isoflavone-7-O-glucoside beta-glucosidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O = daidzein + beta-D-glucose." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of glycosylceramidase activity ; GO:0017042.
is_obsolete: true
consider: GO:0017042

[Term]
id: GO:0102670
name: 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine." [EC:2.1.1.212, GOC:pz]
xref: EC:2.1.1.212
xref: MetaCyc:RXN-3624
xref: RHEA:31371
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102671
name: 6a-hydroxymaackiain-3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = H+ + (+)-pisatin + S-adenosyl-L-homocysteine." [EC:2.1.1.270, GOC:pz]
xref: EC:2.1.1.270
xref: MetaCyc:RXN-4002
xref: RHEA:35471
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102672
name: fatty acid alpha-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-saturated fatty acid + O2 = a (2R)-2-hydroperoxy fatty acid." [RHEA:63508]
synonym: "fatty acid alpha-oxygenase activity" BROAD []
xref: EC:1.13.11.92
xref: MetaCyc:RXN-4121
xref: RHEA:63508
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102673
name: fatty aldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a fatty aldehyde + H2O + NAD+ = a fatty acid + 2 H+ + NADH." [RHEA:49832]
synonym: "fatty aldehyde dehydrogenase activity" EXACT []
xref: MetaCyc:RXN-4142
xref: RHEA:49832
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0102674
name: obsolete C4-demethylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 24-methylenelophenol + a demethylated methyl acceptor = 9xi-episterol + a methylated methyl acceptor." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this actvity exists.
is_obsolete: true

[Term]
id: GO:0102675
name: obsolete C4-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 24-ethylidenelophenol + a demethylated methyl acceptor = avenasterol + a methylated methyl acceptor." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this actvity exists.
is_obsolete: true

[Term]
id: GO:0102676
name: obsolete avenasterol-desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: avenasterol + O2 + NADPH + H+ = 5-dehydroavenasterol + 2 H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of delta7-sterol 5(6)-desaturase activity ; GO:0050046.
is_obsolete: true
replaced_by: GO:0050046

[Term]
id: GO:0102677
name: obsolete campesterol,NADPH:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + campesterol + O2 + NADPH = (22S)-22-hydroxycampesterol + H2O + NADP." [GOC:pz]
comment: The reason for obsoletion is that this term represents a unnecessarily narrow substrate-specific form of GO:0160191 steroid 22S-hydroxylase activity.
is_obsolete: true
replaced_by: GO:0160191

[Term]
id: GO:0102678
name: obsolete 22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP = H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true
replaced_by: GO:0047751

[Term]
id: GO:0102679
name: (5alpha)-campestan-3-one hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH = (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP." [GOC:pz, PMID:10377996]
xref: MetaCyc:RXN-4230
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102680
name: obsolete campest-4-en-3-one hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH = (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102681
name: obsolete isoamylase (maltodextrin-releasing) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: n H2O + a glycogen = n a maltodextrin." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102682
name: cytokinin riboside 5'-monophosphate phosphoribohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate." [GOC:pz, RHEA:48560]
synonym: "N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity" EXACT []
xref: EC:3.2.2.n1
xref: MetaCyc:RXN-4313
xref: RHEA:48560
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0102684
name: L-phenylalanine N-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ = (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide." [EC:1.14.14.40, GOC:pz]
xref: EC:1.14.14.40
xref: MetaCyc:RXN-4602
xref: RHEA:33263
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102685
name: obsolete UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin = H+ + trans-zeatin-7-N-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102686
name: obsolete UDP-glucose:trans-zeatin 9-N-glucosyltransferase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin = H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-)." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102687
name: obsolete UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin = H+ + dihydrozeatin-7-N-glucose + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102688
name: obsolete dihydrozeatin UDP glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin = H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102689
name: obsolete UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102690
name: obsolete isopentenyladenine UDP glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102691
name: obsolete UDP-glucose:benzyladenine 7-N-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine = H+ + benzyladenine-7-N-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102692
name: obsolete benzyladenine UDP glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine = H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102693
name: obsolete UDP-glucose:kinetin 7-N-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + kinetin = H+ + kinetin-7-N-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102694
name: obsolete kinetin UDP glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + kinetin = H+ + 9-(alpha-D-glucosyl)kinetin + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102695
name: obsolete UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + cis-zeatin-7-N-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102696
name: obsolete cis-zeatin UDP glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102697
name: obsolete trans-zeatin-O-glucoside UDP glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102698
name: 5-epi-aristolochene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphoric acid." [EC:4.2.3.61, GOC:pz]
xref: EC:4.2.3.61
xref: MetaCyc:RXN-4781
xref: RHEA:28635
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102699
name: obsolete 2-methylpropionitrile hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH = 2-hydroxy-2-methylpropanenitrile + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102700
name: alpha-thujene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate(3-) = alpha-thujene + diphosphoric acid." [MetaCyc:RXN-5105]
xref: MetaCyc:RXN-5105
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102701
name: tricyclene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate(3-) = tricyclene + diphosphoric acid." [EC:4.2.3.105, GOC:pz]
xref: EC:4.2.3.105
xref: MetaCyc:RXN-5121
xref: RHEA:32687
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102702
name: 2-carene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (+)-2-carene + diphosphoric acid." [GOC:pz, PMID:10700382]
xref: MetaCyc:RXN-5122
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102703
name: camphene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (-)-camphene + diphosphoric acid." [EC:4.2.3.117, GOC:pz]
xref: EC:4.2.3.117
xref: MetaCyc:RXN-5142
xref: RHEA:25484
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102704
name: GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol = H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol." [EC:2.4.1.257, GOC:pz]
xref: EC:2.4.1.257
xref: MetaCyc:RXN-5463
xref: RHEA:29519
is_a: GO:0033164 ! glycolipid 1,6-alpha-mannosyltransferase activity

[Term]
id: GO:0102705
name: serine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + L-serine = ethanolaminium(1+) + carbon dioxide." [GOC:pz, PMID:11461929, RHEA:45824]
xref: MetaCyc:RXN-5641
xref: RHEA:45824
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0102706
name: obsolete butein:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aureusidin synthase activity ; GO:0033793.
is_obsolete: true
replaced_by: GO:0033793

[Term]
id: GO:0102707
name: obsolete S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as amine N-methyltransferase activity ; GO:0030748.
is_obsolete: true
replaced_by: GO:0030748

[Term]
id: GO:0102708
name: obsolete S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102709
name: obsolete S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102710
name: D-inositol-3-phosphate glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+." [GOC:pz, RHEA:26188]
xref: EC:2.4.1.250
xref: MetaCyc:RXN-6501
xref: RHEA:26188
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102711
name: obsolete gibberellin A25,oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 = gibberellin A13 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102712
name: obsolete gibberellin A13,oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 = gibberellin A43 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102713
name: obsolete gibberellin A25 hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 = gibberellin A46 + succinate(2-) + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102714
name: obsolete gibberellin A12,oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A14 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102715
name: obsolete gibberellin A17,oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 = gibberellin A28 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102716
name: obsolete gibberellin A28,oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 = (2betaOH)-gibberellin28 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102717
name: DIBOA-glucoside oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate = TRIBOA-beta-D-glucoside + succinate + carbon dioxide." [EC:1.14.11.59, GOC:pz]
xref: EC:1.14.11.59
xref: MetaCyc:RXN-6685
xref: RHEA:32115
is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

[Term]
id: GO:0102718
name: TRIBOA-glucoside methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine = (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.241, GOC:pz]
xref: EC:2.1.1.241
xref: MetaCyc:RXN-6687
xref: RHEA:32099
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102719
name: obsolete S-adenosyl-L-methionine:eugenol-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of (iso)eugenol O-methyltransferase activity ; GO:0050630.
is_obsolete: true
replaced_by: GO:0050630

[Term]
id: GO:0102720
name: acetyl-coenzyme A:acetyl alcohol acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + benzyl alcohol = benzyl acetate + CoA. Also converts (E)-cinnamyl alcohol into (E)-cinnamyl acetate." [EC:2.3.1.224]
xref: EC:2.3.1.224
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102721
name: ubiquinol:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone." [GOC:pz, RHEA:30255]
xref: EC:1.10.3.11
xref: MetaCyc:RXN-6883
xref: RHEA:30255
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0102722
name: obsolete gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-hydroxybutyrate + NAD(P) = 4-oxobutanoate + H+ + NAD(P)H." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this reaction exists.
is_obsolete: true

[Term]
id: GO:0102723
name: obsolete UDP-glucose:curcumin glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102724
name: obsolete UDP-glucose:curcumin monoglucoside glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102725
name: obsolete 24-methyldesmosterol reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102726
name: DIMBOA glucoside beta-D-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose." [EC:3.2.1.182, GOC:pz]
xref: EC:3.2.1.182
xref: MetaCyc:RXN-7082
xref: RHEA:33975
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102727
name: obsolete 3beta-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102728
name: obsolete campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true
replaced_by: GO:0047751

[Term]
id: GO:0102729
name: obsolete 6-oxocampestanol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP." [GOC:pz]
comment: The reason for obsoletion is that this term represents a unnecessarily narrow substrate-specific form of GO:0160191 steroid 22S-hydroxylase activity.
is_obsolete: true
replaced_by: GO:0160191

[Term]
id: GO:0102730
name: obsolete cathasterone hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor = teasterone + H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102731
name: inositol-1,3,4,6-tetrakisphosphate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP + H+." [MetaCyc:RXN-7185, PMID:16107538]
synonym: "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity" EXACT []
xref: MetaCyc:RXN-7185
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0102732
name: inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H+." [MetaCyc:RXN-7186, PMID:12226109]
synonym: "1D-myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity" EXACT []
synonym: "1D-myo-inositol-pentakisphosphate 5-kinase activity" BROAD []
synonym: "inositol-pentakisphosphate 5-kinase activity" BROAD []
xref: MetaCyc:RXN-7186
is_a: GO:0120517 ! inositol pentakisphosphate kinase activity

[Term]
id: GO:0102733
name: typhasterol C-23 hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor." [GOC:pz, PMID:17138693]
xref: MetaCyc:RXN-719
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0102734
name: brassinolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: castasterone + O2 + reduced [NADPH--hemoprotein reductase] = brassinolide + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Broad specificity for several brassinosteroids, including castasterone, teasterone, and typhasterol." [EC:1.14.14.180]
xref: EC:1.14.14.180
xref: MetaCyc:RXN-720
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102735
name: trihydroxybenzophenone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide." [GOC:pz, RHEA:35143]
xref: EC:2.3.1.220
xref: MetaCyc:RXN-7481
xref: RHEA:35143
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102737
name: obsolete p-coumaroyltriacetic acid synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA = 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102738
name: obsolete (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate = gibberellin A37 + carbon dioxide + succinate." [GOC:pz]
comment: This term was obsoleted because it is a specific substrate of gibberellin 20-oxidase activity ; GO:0045544.
is_obsolete: true
replaced_by: GO:0045544

[Term]
id: GO:0102739
name: obsolete (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate = H+ + gibberellin A4 + succinate + 2 carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is a specific substrate of gibberellin 20-oxidase activity ; GO:0045544.
is_obsolete: true
replaced_by: GO:0045544

[Term]
id: GO:0102740
name: obsolete theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: theobromine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of caffeine synthase activity ; GO:0102741.
is_obsolete: true
replaced_by: GO:0102741

[Term]
id: GO:0102741
name: caffeine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine. Also converts theobromine to caffeine and 7-methylxanthine to theobromine." [EC:2.1.1.160]
synonym: "3N-methyltransferase activity" RELATED []
synonym: "dimethylxanthine methyltransferase activity" RELATED []
synonym: "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity" NARROW []
synonym: "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity" NARROW []
xref: EC:2.1.1.160
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102742
name: obsolete R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH = (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as hydroxyphenylpyruvate reductase activity ; GO:0047995.
is_obsolete: true
replaced_by: GO:0047995

[Term]
id: GO:0102743
name: obsolete eriodictyol,NADPH:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 = 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102744
name: obsolete all-trans-geranyl-geranyl diphosphate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102745
name: obsolete dihydrogeranylgeranyl-PP reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102746
name: obsolete tetrahydrogeranylgeranyl-PP reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102747
name: obsolete chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) = geranylgeranyl-chlorophyll a + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102748
name: obsolete geranylgeranyl-chlorophyll a reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102749
name: obsolete dihydrogeranylgeranyl-chlorophyll a reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102750
name: obsolete tetrahydrogeranylgeranyl-chlorophyll a reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102751
name: obsolete UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a subreaction of glycogenin glucosyltransferase activity ; GO:0008466.
is_obsolete: true
replaced_by: GO:0008466

[Term]
id: GO:0102752
name: obsolete 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a glucosylated glycogenin = a glycogen." [GOC:pz]
comment: The reason for obsoletion is that this term is equivalent to GO:0003844 1,4-alpha-glucan branching enzyme activity.
is_obsolete: true
replaced_by: GO:0003844

[Term]
id: GO:0102753
name: obsolete chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate = geranylgeranyl-chlorophyll b + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102754
name: obsolete chlorophyllide-b:phytyl-diphosphate phytyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate = chlorophyll b + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102755
name: obsolete gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0016707

[Term]
id: GO:0102756
name: obsolete very-long-chain 3-ketoacyl-CoA synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA." [GOC:pz]
comment: This term was obsoleted because it represents the same actvity as fatty acid elongase activity ; GO:0009922.
is_obsolete: true
replaced_by: GO:0009922

[Term]
id: GO:0102757
name: NADPH phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate." [GOC:pz, RHEA:60664]
xref: MetaCyc:RXN-7703
xref: RHEA:60664
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0102758
name: very-long-chain enoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH. This reaction is the fourth (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:14473]
xref: EC:1.3.1.93
xref: MetaCyc:RXN-7711
xref: RHEA:14473
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102759
name: obsolete campestanol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + campestanol + O2 + NADPH = 6-deoxycathasterone + H2O + NADP." [GOC:pz]
comment: The reason for obsoletion is that this term represents a unnecessarily narrow substrate-specific form of GO:0160191 steroid 22S-hydroxylase activity.
is_obsolete: true
replaced_by: GO:0160191

[Term]
id: GO:0102760
name: obsolete 6-deoxocathasterone hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor = 6-deoxoteasterone + H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as 22alpha-hydroxysteroid 23-monooxygenase activity ; GO:0102097.
is_obsolete: true
replaced_by: GO:0102097

[Term]
id: GO:0102761
name: eriodictyol 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-eriodictyol + S-adenosyl-L-methionine = (S)-homoeriodictyol + H+ + S-adenosyl-L-homocysteine." [RHEA:60948]
xref: MetaCyc:RXN-7753
xref: RHEA:60948
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102762
name: eriodictyol 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + hesperetin(1-) + S-adenosyl-L-homocysteine." [GOC:pz, MetaCyc:RXN-7754]
xref: MetaCyc:RXN-7754
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102763
name: phytyl-P kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a ribonucleoside 5'-triphosphate + phytyl phosphate = a ribonucleoside 5'-diphosphate + phytyl diphosphate." [RHEA:38099]
xref: MetaCyc:RXN-7763
xref: RHEA:38099
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0102764
name: obsolete 6-deoxotyphasterol C-23 hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102765
name: UDP-D-apiose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide." [GOC:pz, MetaCyc:RXN-7770]
xref: MetaCyc:RXN-7770
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0102766
name: naringenin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine = sakuranetin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.232, GOC:pz]
xref: EC:2.1.1.232
xref: MetaCyc:RXN-7773
xref: RHEA:31539
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102767
name: flavanone 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine." [EC:2.1.1.231, GOC:pz]
xref: EC:2.1.1.231
xref: MetaCyc:RXN-12719
xref: RHEA:31743
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102768
name: obsolete anthocyanidin synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102769
name: obsolete dihydroceramide glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of ceramide glucosyltransferase activity ; GO:0008120
is_obsolete: true
replaced_by: GO:0008120

[Term]
id: GO:0102770
name: inositol phosphorylceramide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol." [MetaCyc:RXN-7795]
xref: MetaCyc:RXN-7795
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0102771
name: dihydroceramide fatty acyl 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O." [RHEA:46512]
synonym: "plant sphingolipid fatty acid 2-hydroxylase actitivy" EXACT [EC:1.14.18.7]
synonym: "sphingolipid very long chain fatty acid alpha-hydroxylase activity" RELATED []
xref: EC:1.14.18.7
xref: MetaCyc:RXN-7796
xref: RHEA:46512
is_a: GO:0080132 ! fatty acid 2-hydroxylase activity

[Term]
id: GO:0102772
name: sphingolipid C4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O." [EC:1.14.18.5, GOC:pz]
synonym: "sphingolipid long-chain base 4-hydroxylase activity" RELATED []
xref: EC:1.14.18.5
xref: MetaCyc:RXN-14250
xref: RHEA:55808
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102773
name: obsolete dihydroceramide kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate." [GOC:pz]
comment: This term was obsoleted because it represents a specific susbtrate of ceramide kinase activity ; GO:0001729.
is_obsolete: true
replaced_by: GO:0001729

[Term]
id: GO:0102774
name: obsolete p-coumaroyltriacetic acid lactone synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( = p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102775
name: obsolete 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102776
name: obsolete UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102777
name: obsolete caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-)." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as anthocyanin 5-aromatic acyltransferase activity ; GO:0047183.
is_obsolete: true
replaced_by: GO:0047183

[Term]
id: GO:0102778
name: delta9-tetrahydrocannabinolate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: cannabigerolate + O2 = delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide." [GOC:pz, RHEA:34135]
xref: EC:1.21.3.7
xref: MetaCyc:RXN-7854
xref: RHEA:34135
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0102779
name: cannabidiolate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: cannabigerolate + O2 = cannabidiolate + hydrogen peroxide." [GOC:pz, RHEA:34411]
xref: EC:1.21.3.8
xref: MetaCyc:RXN-7855
xref: RHEA:34411
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0102780
name: obsolete sitosterol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + sitosterol + O2 + NADPH = (22alpha)-hydroxy-sitosterol + H2O + NADP." [GOC:pz]
comment: The reason for obsoletion is that this term represents a unnecessarily narrow substrate-specific form of GO:0160191 steroid 22S-hydroxylase activity.
is_obsolete: true
replaced_by: GO:0160191

[Term]
id: GO:0102781
name: obsolete isofucosterol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH = (22alpha)-hydroxy-isofucosterol + H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102782
name: obsolete cholestanol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102783
name: obsolete beta-carotene oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this activity exists.
is_obsolete: true

[Term]
id: GO:0102784
name: obsolete lutein oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of beta,beta-carotene-9',10'-cleaving oxygenase activity ; GO:0102076.
is_obsolete: true
consider: GO:0102076

[Term]
id: GO:0102785
name: violaxanthin oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial." [GOC:pz, PMID:11316814]
xref: MetaCyc:RXN-7886
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102786
name: obsolete stearoyl-[acp] desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as acyl-[acyl-carrier-protein] desaturase activity ; GO:0045300.
is_obsolete: true
replaced_by: GO:0045300

[Term]
id: GO:0102787
name: obsolete caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102788
name: obsolete 4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102789
name: obsolete UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102790
name: obsolete cyanidin 5,3-O-glycosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102791
name: obsolete sulfuretin synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aureusidin synthase activity ; GO:0033793.
is_obsolete: true
replaced_by: GO:0033793

[Term]
id: GO:0102792
name: obsolete sinapaldehyde:NAD(P)+ oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O = 2 H+ + trans-sinapate + NADPH." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102793
name: soyasapogenol B glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B = H+ + UDP + soyasapogenol B 3-O-beta-glucuronate." [EC:2.4.1.262, GOC:pz]
xref: EC:2.4.1.262
xref: MetaCyc:RXN-8086
xref: RHEA:31475
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102794
name: obsolete cinnamaldehyde:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aryl-aldehyde oxidase activity ; GO:0018488.
is_obsolete: true
replaced_by: GO:0018488

[Term]
id: GO:0102795
name: obsolete 1-naphthaldehyde:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aryl-aldehyde oxidase activity ; GO:0018488.
is_obsolete: true
replaced_by: GO:0018488

[Term]
id: GO:0102796
name: obsolete protocatechualdehyde:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O = H+ + 3,4-dihydroxybenzoate + hydrogen peroxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aryl-aldehyde oxidase activity ; GO:0018488.
is_obsolete: true
replaced_by: GO:0018488

[Term]
id: GO:0102797
name: obsolete geranial:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: geranial + O2 + H2O = H+ + geranate + hydrogen peroxide." [GOC:pz]
comment: This term has been obsoleted because it is beyond the scope of GO.
is_obsolete: true
replaced_by: GO:0004031

[Term]
id: GO:0102798
name: obsolete heptaldehyde:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: heptanal + O2 + H2O = H+ + heptanoate + hydrogen peroxide." [GOC:pz]
comment: This term has been obsoleted because it is beyond the scope of GO.
is_obsolete: true
replaced_by: GO:0004031

[Term]
id: GO:0102799
name: obsolete glucosinolate glucohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as thioglucosidase activity ; GO:0019137.
is_obsolete: true
replaced_by: GO:0019137

[Term]
id: GO:0102800
name: obsolete caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102801
name: anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A." [GOC:pz, RHEA:35515]
xref: EC:2.3.1.214
xref: MetaCyc:RXN-8139
xref: RHEA:35515
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102802
name: thebaine 6-O-demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + carbon dioxide." [EC:1.14.11.31, GOC:pz]
xref: EC:1.14.11.31
xref: MetaCyc:RXN-8147
xref: RHEA:27477
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0102803
name: obsolete thebane O-demethylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 = oripavine + formaldehyde + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents another substrate for codeine O-demethylase activity ; GO:0102805.
is_obsolete: true
consider: GO:0102805

[Term]
id: GO:0102804
name: obsolete oripavine 6-O-demethylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 = morphinone + formaldehyde + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as thebaine 6-O-demethylase activity ; GO:0102802.
is_obsolete: true
replaced_by: GO:0102802

[Term]
id: GO:0102805
name: codeine O-demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CO2." [RHEA:27413]
xref: EC:1.14.11.32
xref: MetaCyc:RXN-8152
xref: RHEA:27413
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0102806
name: obsolete 4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine = shisonin + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102807
name: obsolete cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-O-sophoroside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102808
name: obsolete pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside = H+ + pelargonidin 3-O-sophoroside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102809
name: obsolete delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside = H+ + delphinidin 3-O-sophoroside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102810
name: glutarate-semialdehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+." [GOC:pz, RHEA:57832]
xref: EC:1.2.1.20
xref: MetaCyc:RXN-8182
xref: RHEA:57832
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102811
name: geraniol 10-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: geraniol + O2 + NADPH + H+ = (6E)-8-hydroxygeraniol + NADP + H2O." [EC:1.14.14.83, GOC:pz]
xref: EC:1.14.14.83
xref: MetaCyc:RXN-8197
xref: RHEA:32495
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102812
name: obsolete 4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102813
name: obsolete UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102814
name: obsolete caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA = delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102815
name: obsolete caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA = delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as anthocyanin 5-aromatic acyltransferase activity ; GO:0047183.
is_obsolete: true
replaced_by: GO:0047183

[Term]
id: GO:0102816
name: UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside = H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP." [EC:2.4.1.298, GOC:pz]
xref: EC:2.4.1.298
xref: MetaCyc:RXN-8234
xref: RHEA:35423
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102817
name: obsolete caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA = gentiodelphin + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102818
name: lycopene cleavage oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: lycopene + 2 O2 = 2 sulcatone + bixin aldehyde." [GOC:pz, MetaCyc:RXN-8236]
xref: MetaCyc:RXN-8236
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0102819
name: obsolete bixin aldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: bixin aldehyde + O2 + NAD = norbixin + NADH + H+." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102820
name: obsolete norbixin methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: norbixin + S-adenosyl-L-methionine = bixin + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102821
name: obsolete bixin methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: bixin + S-adenosyl-L-methionine = bixin dimethyl ester + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102822
name: flavone 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H+ + S-adenosyl-L-homocysteine." [RHEA:55332]
synonym: "luteolin O-methyltransferase activity" NARROW []
synonym: "quercetin 3'-O-methyltransferase activity" NARROW []
xref: EC:2.1.1.42
xref: MetaCyc:RXN-8262
xref: RHEA:55332
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0102823
name: obsolete kaempferol-3-rhamnoside-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside = kaempferol 3-O-rhamnoside-7-O-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102824
name: obsolete UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose = H+ + quercetin 3-O-rhamnoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102825
name: obsolete quercetin 3-O-rhamnoside-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside = quercetin 3-O-rhamnoside-7-O-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102826
name: obsolete kaempferol-3-glucoside-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside = kaempferol 3,7-O-diglucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102827
name: obsolete galactosylononitol-raffinose galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102828
name: obsolete stachyose galactinol:verbascose galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = verbascose + myo-inositol." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102829
name: obsolete ajugose synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 verbascose = ajugose + stachyose." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102830
name: verbascose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 stachyose = verbascose + raffinose." [GOC:pz, PMID:12060258]
xref: MetaCyc:RXN-8286
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102831
name: stachyose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 raffinose = stachyose + sucrose." [GOC:pz, PMID:12060258]
xref: MetaCyc:RXN-8287
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102832
name: verbascose galactinol:ajugose galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = ajugose + myo-inositol." [GOC:pz, PMID:11675396]
xref: MetaCyc:RXN-8288
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102833
name: obsolete sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol = D-galactosylononitol + myo-inositol." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102834
name: obsolete 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133]
comment: This term was obsoleted because it represents the same activity as acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102835
name: obsolete 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102836
name: obsolete 1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918]
comment: This term was obsoleted because it represents the same activity as acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102837
name: obsolete 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102838
name: obsolete 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102839
name: obsolete 1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102840
name: obsolete 1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102841
name: obsolete 1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:11607123]
comment: This term was obsoleted because it represents the same activity as acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102842
name: obsolete 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity ; GO:0102993.
is_obsolete: true

[Term]
id: GO:0102843
name: palmitoyl-[glycerolipid] 7-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [RHEA:46756]
synonym: "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming)" EXACT []
xref: EC:1.14.19.42
xref: MetaCyc:RXN-16048
xref: RHEA:46756
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102844
name: obsolete 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102845
name: obsolete 1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of palmitoyl-[glycerolipid] 3-(E)-desaturase activity ; GO:0102654.
is_obsolete: true
replaced_by: GO:0102654

[Term]
id: GO:0102846
name: obsolete 1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102847
name: obsolete 1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102848
name: obsolete 1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102849
name: obsolete 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102850
name: acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: a (9Z)-octadecenoyl-containing glycerolipid + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [RHEA:46376]
synonym: "1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity" EXACT []
xref: EC:1.14.19.23
xref: RHEA:46376
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102851
name: obsolete 1-18:2-2-16:0-phosphatidylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of palmitoyl-[glycerolipid] 3-(E)-desaturase activity ; GO:0102654.
is_obsolete: true
replaced_by: GO:0102654

[Term]
id: GO:0102852
name: obsolete 1-18:3-2-16:0-phosphatidylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of palmitoyl-[glycerolipid] 3-(E)-desaturase activity ; GO:0102654.
is_obsolete: true
replaced_by: GO:0102654

[Term]
id: GO:0102853
name: obsolete 1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of acyl-lipid omega-6 desaturase (cytochrome b5) activity ; GO:0050184.
is_obsolete: true
replaced_by: GO:0050184

[Term]
id: GO:0102854
name: obsolete 1-18:2-2-18:1-phosphatidylcholine desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as [acyl-lipid omega-3 desaturase (cytochrome b5) activity ; GO:0102859.
is_obsolete: true
replaced_by: GO:0102859

[Term]
id: GO:0102856
name: obsolete 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted bcause it represents a specific substrate of acyl-lipid omega-3 desaturase (cytochrome b5) activity ; GO:0102859.
is_obsolete: true
replaced_by: GO:0102859

[Term]
id: GO:0102858
name: obsolete 1-18:2-2-18:3-phosphatidylcholine desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it was deprecated in the source database.
is_obsolete: true

[Term]
id: GO:0102859
name: acyl-lipid omega-3 desaturase (cytochrome b5) activity
namespace: molecular_function
def: "Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O." [RHEA:46404]
synonym: "1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)" EXACT []
xref: EC:1.14.19.25
xref: MetaCyc:RXN-16046
xref: RHEA:46404
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102862
name: obsolete 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted bcause it represents a specific substrate of acyl-lipid omega-3 desaturase (cytochrome b5) activity ; GO:0102859.
is_obsolete: true
replaced_by: GO:0102859

[Term]
id: GO:0102863
name: obsolete 1-18:3-2-18:1-phosphatidylcholine desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of acyl-lipid omega-6 desaturase (cytochrome b5) activity ; GO:0050184.
is_obsolete: true
replaced_by: GO:0050184

[Term]
id: GO:0102864
name: obsolete 1-18:3-2-18:2-phosphatidylcholine desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of acyl-lipid omega-3 desaturase (cytochrome b5) activity ; GO:0102859.
is_obsolete: true
replaced_by: GO:0102859

[Term]
id: GO:0102865
name: delta6-acyl-lipid desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O." [GOC:pz, PMID:10848999, RHEA:46536]
xref: EC:1.14.19.38
xref: MetaCyc:RXN-8343
xref: RHEA:46536
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102866
name: acyl-lipid (8-3)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O. Also converts an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid into a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid." [EC:1.14.19.30]
synonym: "acyl-lipid 5-desaturase activity" RELATED []
synonym: "Delta(5)-fatty-acid desaturase activity" EXACT []
synonym: "di-homo-gamma-linolenate delta5 desaturase activity" RELATED []
xref: EC:1.14.19.30
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102867
name: obsolete molybdenum cofactor sulfurtransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine = thio-molybdenum cofactor + L-alanine + H2O." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as molybdenum cofactor sulfurase activity ; GO:0008265.
is_obsolete: true
replaced_by: GO:0008265

[Term]
id: GO:0102868
name: obsolete 24-epi-campsterol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 = brassicasterol + NADP + 2 H2O." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102869
name: obsolete 6-hydroxyflavone-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone = 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102870
name: obsolete 7-hydroxyflavone-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone = 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102872
name: obsolete 1-16:0-2-18:2-phosphatidylcholine desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor = 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15538555, PMID:8102138]
comment: This term was obsoleted bcause it represents a specific substrate of acyl-lipid omega-3 desaturase (cytochrome b5) activity ; GO:0102859.
is_obsolete: true
replaced_by: GO:0102859

[Term]
id: GO:0102873
name: obsolete 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133]
comment: This term was obsoleted because it represents the same activity as acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity ; GO:0102850.
is_obsolete: true
replaced_by: GO:0102850

[Term]
id: GO:0102874
name: obsolete 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:17064923]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102875
name: obsolete 1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of linolenate delta15 desaturase activity ; GO:0102993.
is_obsolete: true
replaced_by: GO:0102993

[Term]
id: GO:0102876
name: psoralen synthase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 = psoralen + NADP + acetone + 2 H2O." [EC:1.14.14.141]
xref: EC:1.14.14.141
xref: MetaCyc:RXN-8386
xref: RHEA:19281
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102877
name: alpha-copaene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-copaene + diphosphoric acid." [EC:4.2.3.133, GOC:pz]
xref: EC:4.2.3.133
xref: MetaCyc:RXN-8416
xref: RHEA:33991
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102878
name: (+)-alpha-barbatene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate." [RHEA:29499]
xref: EC:4.2.3.69
xref: MetaCyc:RXN-8417
xref: RHEA:29499
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102879
name: (+)-thujopsene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-thujopsene + diphosphoric acid." [GOC:pz, RHEA:30375]
xref: EC:4.2.3.79
xref: MetaCyc:RXN-8418
xref: RHEA:30375
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102880
name: obsolete isobazzanene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = isobazzanene + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102881
name: (+)-beta-barbatene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate = (-)-beta-barbatene + diphosphate." [PMID:15918888, PMID:16297850, RHEA:73983]
xref: MetaCyc:RXN-8421
xref: RHEA:73983
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102882
name: beta-acoradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate = beta-acoradiene + diphosphate." [RHEA:68520]
xref: MetaCyc:RXN-8423
xref: RHEA:68520
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102883
name: (+)-beta-chamigrene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate." [RHEA:30379]
xref: EC:4.2.3.78
xref: MetaCyc:RXN-8424
xref: RHEA:30379
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102884
name: alpha-zingiberene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = zingiberene + diphosphoric acid." [EC:4.2.3.65, GOC:pz]
xref: EC:4.2.3.65
xref: MetaCyc:RXN-8425
xref: RHEA:28643
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102885
name: alpha-cuprenene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphoric acid." [EC:4.2.3.95, GOC:pz]
xref: EC:4.2.3.95
xref: MetaCyc:RXN-8426
xref: RHEA:32027
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102886
name: obsolete alpha-chamigrene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-chamigrene + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102887
name: beta-sesquiphellandrene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-sesquiphellandrene + diphosphoric acid." [EC:4.2.3.123, GOC:pz]
xref: EC:4.2.3.123
xref: MetaCyc:RXN-8430
xref: RHEA:32699
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102888
name: obsolete delta-cuprenene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = delta-cuprenene + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102889
name: beta-elemene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-elemene + diphosphoric acid." [MetaCyc:RXN-8432]
xref: MetaCyc:RXN-8432
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102890
name: chalcone 4'-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone = UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+. Also converts 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose into 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside." [EC:2.4.1.286]
synonym: "naringenin chalcone 4'-O-glucosyltransferase activity" NARROW []
xref: EC:2.4.1.286
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102891
name: obsolete 2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone = H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of chalcone 4'-O-glucosyltransferase activity ; GO:0102890.
is_obsolete: true
replaced_by: GO:0102890

[Term]
id: GO:0102892
name: obsolete betanidin 5-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + betanidin = H+ + betanin + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102893
name: obsolete betanidin 6-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + betanidin = H+ + gomphrenin I + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102894
name: UDPG:cyclo-DOPA 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome = H+ + cyclo-dopa 5-O-glucoside + UDP." [GOC:pz, PMID:15196939, PMID:15695438]
xref: MetaCyc:RXN-8481
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102895
name: colneleate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9(S)-HPODE = colneleate + H2O." [EC:4.2.1.121, GOC:pz]
xref: EC:4.2.1.121
xref: MetaCyc:RXN-8496
xref: RHEA:28174
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0102896
name: obsolete colnelenate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate = colnelenate + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102897
name: obsolete abietadienal hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: abietal + NADPH + O2 = abietate + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102898
name: obsolete levopimaradienol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 = levopiramadiene-diol + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102899
name: obsolete dehydroabietadienol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 = dehydroabietadiene-diol + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102900
name: obsolete dehydroabietadienal hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dehydroabietadienal + NADPH + O2 = dehydroabietic acid + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102901
name: obsolete isopimaradienol hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 = isopimaradiene-diol + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102902
name: obsolete isopimaradienal hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isopimaradienal + NADPH + O2 = isopimaric acid + NADP + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102903
name: gamma-terpinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid." [GOC:pz, RHEA:32559]
xref: EC:4.2.3.114
xref: MetaCyc:RXN-8547
xref: RHEA:32559
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102904
name: germacrene C synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid." [EC:4.2.3.60, GOC:pz]
xref: EC:4.2.3.60
xref: MetaCyc:RXN-8561
xref: RHEA:28302
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102905
name: valencene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = (+)-valencene + diphosphoric acid." [EC:4.2.3.73, GOC:pz]
xref: EC:4.2.3.73
xref: MetaCyc:RXN-8608
xref: RHEA:29511
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102906
name: 7-epi-alpha-selinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = (-)-7-epi-alpha-selinene + diphosphoric acid." [EC:4.2.3.86, GOC:pz]
xref: EC:4.2.3.86
xref: MetaCyc:RXN-8609
xref: RHEA:30383
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102907
name: obsolete sesquisabinene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + sesquisabinene." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102909
name: obsolete alpha-ketoglutarate reductase activity (NADH-dependent)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: NAD + 2-hydroxyglutarate = H+ + 2-oxoglutarate + NADH." [GOC:pz]
comment: This term was obsoleted because there is no evidence that this reaction exists.
is_obsolete: true

[Term]
id: GO:0102910
name: dirigent protein activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + 2 coniferol + O2 = (+)-pinoresinol + 2 H2O. The The protein encoding this activity has been termed 'dirigent protein' because it does not express any catalytic activity and serves only to bind and orientate the coniferyl alcohol-derived free radicals." [GOC:pz, MetaCyc:RXN-8677, PMID:37202648]
xref: MetaCyc:RXN-8677
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0102911
name: obsolete (-)-secoisolariciresinol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (-)-secoisolariciresinol + NAD = H+ + (-)-lactol + NADH." [GOC:pz]
comment: This term was obsoleted because it represents a subreaction of secoisolariciresinol dehydrogenase activity ; GO:0120529.
is_obsolete: true
replaced_by: GO:0120529

[Term]
id: GO:0102912
name: obsolete (-)-lactol dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (-)-lactol + NAD = H+ + (-)-matairesinol + NADH." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0120529

[Term]
id: GO:0102913
name: 3-aminomethylindole N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(aminomethyl)indole + S-adenosyl-L-methionine = (1H-indol-3-yl)-N-methylmethanamine + H+ + S-adenosyl-L-homocysteine." [RHEA:52268]
xref: MetaCyc:RXN-8686
xref: RHEA:52268
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102914
name: obsolete N-methyl-3-aminomethylindole N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102915
name: piperitol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 = (+)-piperitol + NADP + 2 H2O." [EC:1.14.19.74, PMID:16785429]
xref: EC:1.14.19.74
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102916
name: obsolete sesamin synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 = (+)-sesamin + NADP + 2 H2O." [GOC:pz, PMID:16785429]
comment: This term was obsoleted because it represents a specific substrate of piperitol synthase activity ; GO:0102915.
is_obsolete: true
replaced_by: GO:0102915

[Term]
id: GO:0102917
name: (R,S)-reticuline 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)- or (R)-reticuline + S-adenosyl-L-methionine = (S)- or (R)-laudanine + H+ + S-adenosyl-L-homocysteine." [EC:2.1.1.291]
synonym: "(R)-reticuline 7-O-methyltransferase activity" EXACT []
synonym: "(S)-reticuline 7-O-methyltransferase activity" EXACT []
xref: EC:2.1.1.291
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102918
name: obsolete (R)-reticuline 7-O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine = (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as (R,S)-reticuline 7-O-methyltransferase activity ; GO:0102917. This reaction is non-stereo-specific.
is_obsolete: true
replaced_by: GO:0102917

[Term]
id: GO:0102919
name: 5,6-dimethylbenzimidazole synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid." [EC:1.13.11.79, GOC:pz]
xref: EC:1.13.11.79
xref: MetaCyc:RXN-8771
xref: RHEA:27345
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102920
name: obsolete acyl coenzyme A: isopenicillin N acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O = H+ + coenzyme A + penicillin K + L-2-aminoadipate." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as isopenicillin-N N-acyltransferase activity ; GO:0050640.
is_obsolete: true
replaced_by: GO:0050640

[Term]
id: GO:0102921
name: mannosylglycerate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate = H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP." [EC:2.4.1.269, GOC:pz]
xref: EC:2.4.1.269
xref: MetaCyc:RXN-8849
xref: RHEA:30639
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102922
name: phenylpropanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA." [RHEA:42488]
xref: MetaCyc:RXN-8857
xref: RHEA:42488
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102923
name: 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H+ + taxol." [RHEA:33687]
xref: MetaCyc:RXN-8859
xref: RHEA:33687
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102924
name: obsolete gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of gibberellin 2-beta-dioxygenase activity ; GO:0045543.
is_obsolete: true
replaced_by: GO:0045543

[Term]
id: GO:0102925
name: obsolete solanine UDP-galactose galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0102926
name: obsolete solanidine glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of sterol 3-beta-glucosyltransferase activity ; GO:0016906.
is_obsolete: true
replaced_by: GO:0016906

[Term]
id: GO:0102927
name: obsolete beta-chaconine rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102928
name: obsolete beta-solanine rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102929
name: obsolete lachrymatory factor synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102930
name: 4-hydroxybenzoate geranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid." [GOC:pz, RHEA:27854]
xref: EC:2.5.1.93
xref: MetaCyc:RXN-8920
xref: RHEA:27854
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0102931
name: (Z,E)-alpha- farnesene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid." [GOC:pz, PMID:17140613]
xref: MetaCyc:RXN-8931
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102932
name: obsolete pterocarpan reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true

[Term]
id: GO:0102933
name: GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate." [GOC:pz, RHEA:36779]
xref: EC:2.6.1.102
xref: MetaCyc:RXN-8953
xref: RHEA:36779
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0102934
name: costunolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP." [GOC:pz, RHEA:28230]
xref: EC:1.14.14.150
xref: MetaCyc:RXN-8971
xref: RHEA:28230
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102935
name: obsolete gypsogenin-UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102936
name: obsolete gypsogenate-UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102937
name: 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP." [GOC:pz]
xref: MetaCyc:RXN-9014
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102938
name: obsolete orcinol O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine." [GOC:pz]
comment: The reason for obsoletion is that it is more specific than the specificity of any known gene product.
is_obsolete: true
replaced_by: GO:0016206

[Term]
id: GO:0102939
name: obsolete 3-methoxy-5-hydroxytoluene O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102940
name: obsolete phloroglucinol O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102941
name: obsolete 3,5-dihydroxyanisole O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102942
name: obsolete 3,5-dimethoxyphenol O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102943
name: trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate." [GOC:pz, RHEA:28182]
xref: EC:5.3.3.17
xref: MetaCyc:RXN-9031
xref: RHEA:28182
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0102944
name: obsolete medicagenate UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate = UDP(3-) + a medicagenate monoglucoside." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102945
name: obsolete soyasapogenol B UDP-glucosyl transferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B = UDP(3-) + a soyasapogenol B monoglucoside." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102946
name: obsolete soyasapogenol E UDP-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E = UDP + a soyasapogenol E monoglucoside." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102947
name: (+)-delta-cadinene-8-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 = 8-hydroxy-(+)-delta-cadinene + NADP + H2O." [GOC:pz]
xref: MetaCyc:RXN-9045
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102948
name: obsolete luteolin C-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102949
name: 1,2-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor." [GOC:pz, PMID:15220389]
xref: MetaCyc:RXN-9082
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102950
name: obsolete indole-3-acetyl-valine synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102951
name: obsolete indole-3-acetyl-phenylalanine synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102952
name: obsolete UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102953
name: hypoglycin A gamma-glutamyl transpeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B." [GOC:pz]
xref: MetaCyc:RXN-9157
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0102954
name: dalcochinase activity
namespace: molecular_function
def: "Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O = dalcochinin + D-glucopyranose." [GOC:pz, PMID:16814564]
xref: MetaCyc:RXN-9162
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102955
name: obsolete S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+." [GOC:pz, PMID:1444716, PMID:9045837]
comment: This term was obsoleted because it represents a specific substrate of demethylmenaquinone methyltransferase activity ; GO:0043770.
is_obsolete: true
replaced_by: GO:0043770

[Term]
id: GO:0102956
name: obsolete UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0102960
name: momilactone-A synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H." [GOC:pz, RHEA:25367]
xref: EC:1.1.1.295
xref: MetaCyc:RXN-9290
xref: RHEA:25367
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102963
name: (S)-corytuberine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 = (S)-corytuberine + NADP + 2 H2O." [PMID:18230623, RHEA:51540]
xref: EC:1.14.19.51
xref: MetaCyc:RXN-9314
xref: RHEA:51540
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102964
name: S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine." [RHEA:51524]
xref: MetaCyc:RXN-9315
xref: RHEA:51524
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102965
name: alcohol-forming long-chain fatty acyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:pz, RHEA:52716]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "alcohol-forming fatty acyl-CoA reductase activity" BROAD []
xref: EC:1.2.1.84
xref: MetaCyc:RXN-9344
xref: RHEA:52716
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102966
name: obsolete arachidoyl-CoA:1-dodecanol O-acyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of long-chain-alcohol O-fatty-acyltransferase activity ; GO:0047196.
is_obsolete: true
replaced_by: GO:0047196

[Term]
id: GO:0102967
name: 10-hydroxygeraniol oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP = (6E)-8-hydroxygeranial + NADPH + H+." [GOC:pz, RHEA:32607]
xref: MetaCyc:RXN-9367
xref: RHEA:32607
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102968
name: 10-hydroxygeranial oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP = (6E)-8-oxogeranial + NADPH + H+." [GOC:pz, RHEA:32611]
xref: MetaCyc:RXN-9369
xref: RHEA:32611
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102969
name: 10-oxogeraniol oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6E)-8-oxogeraniol + NADP = (6E)-8-oxogeranial + NADPH + H+." [GOC:pz, RHEA:32615]
xref: MetaCyc:RXN-9370
xref: RHEA:32615
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102970
name: 7-deoxyloganetic acid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate = H+ + 7-deoxyloganate + UDP." [EC:2.4.1.323, GOC:pz]
xref: EC:2.4.1.323
xref: MetaCyc:RXN-9372
xref: RHEA:39895
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102971
name: phosphinothricin N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + phosphinothricin = H+ + coenzyme A(4-) + N-acetylphosphinatothricinate." [EC:2.3.1.183, GOC:pz]
xref: EC:2.3.1.183
xref: MetaCyc:RXN-9382
xref: RHEA:12597
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102972
name: obsolete gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0045543

[Term]
id: GO:0102973
name: norsolorinate anthrone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]." [EC:2.3.1.221, GOC:pz]
synonym: "norsolorinic acid synthase" EXACT []
xref: EC:2.3.1.221
xref: MetaCyc:RXN-9479
xref: RHEA:35179
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0102974
name: hydroxyversicolorone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH." [RHEA:35691]
xref: MetaCyc:RXN-9489
xref: RHEA:35691
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102975
name: versiconal hemiacetal acetate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: versiconol acetate + NADP = versiconal hemiacetal acetate + NADPH." [RHEA:35695]
xref: MetaCyc:RXN-9490
xref: RHEA:35695
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102976
name: versiconal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-versicolorone + NADP+ = 1'-hydroxyversicolorone + H+ + NADPH." [RHEA:35699]
xref: MetaCyc:RXN-9491
xref: RHEA:35699
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102977
name: obsolete nitrilotriacetate monooxygenase activity (FMN-dependent)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN." [GOC:pz]
comment: This term was obsoleted because it represents the same reaction as nitrilotriacetate monooxygenase activity ; GO:0018529.
is_obsolete: true
replaced_by: GO:0018529

[Term]
id: GO:0102978
name: furaneol oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP = 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+." [EC:1.3.1.105, GOC:pz]
xref: EC:1.3.1.105
xref: MetaCyc:RXN-9563
xref: RHEA:39111
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102979
name: obsolete homofuraneol oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: homofuraneol + NADP = (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true
replaced_by: GO:0102978

[Term]
id: GO:0102980
name: obsolete 2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP = (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true
replaced_by: GO:0102978

[Term]
id: GO:0102981
name: obsolete 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP = (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true
consider: GO:0102978

[Term]
id: GO:0102982
name: UDP-3-dehydro-alpha-D-glucose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + NAD = H+ + UDP-3-keto-alpha-D-glucose + NADH." [GOC:pz, PMID:11278540]
xref: MetaCyc:RXN-9578
xref: RHEA:35755
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102983
name: xylogalacturonan beta-1,3-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan = UDP + 4 H+ + a xylogalacturonan." [EC:2.4.2.41, GOC:pz]
xref: EC:2.4.2.41
xref: MetaCyc:RXN-9589
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0102984
name: sulfoacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD = sulfonatoacetate + NADH + 2 H+." [EC:1.2.1.73, GOC:pz]
xref: EC:1.2.1.73
xref: MetaCyc:RXN-9592
xref: RHEA:25637
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102985
name: delta12-fatty-acid desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Also converts (9Z)-octadecenoyl-CoA into (9Z,12Z)-octadecadienoyl-CoA. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9." [EC:1.14.19.6]
xref: EC:1.14.19.6
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102986
name: trehalose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucose = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H+." [RHEA:47416]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
xref: EC:2.4.1.245
xref: MetaCyc:RXN-9603
xref: RHEA:47416
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0102987
name: obsolete palmitoleic acid delta 12 desaturase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor = (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of delta12-fatty-acid desaturase activity ; GO:0102985.
is_obsolete: true
replaced_by: GO:0102985

[Term]
id: GO:0102988
name: 9,12-cis-hexadecadienoic acid delta 15 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor = 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.13]
xref: EC:1.14.19.13
xref: MetaCyc:RXN-9617
xref: RHEA:46232
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102989
name: obsolete 5-pentadecatrienylresorcinol synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) = 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102990
name: 5-n-alk(en)ylresorcinol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H+ + S-adenosyl-L-homocysteine." [RHEA:26325]
xref: EC:2.1.1.n7
xref: MetaCyc:RXN-9619
xref: RHEA:26325
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102991
name: obsolete myristoyl-CoA hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: myristoyl-CoA + H2O = H+ + tetradecanoate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of long-chain fatty acyl-CoA hydrolase activity ; GO:0052816.
is_obsolete: true
replaced_by: GO:0052816

[Term]
id: GO:0102992
name: obsolete 2-methylbutyronitrile hydroxylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 = H2O + NADP + 2-hydroxy-2-methylbutyronitrile." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0102993
name: sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]. Also converts a (7Z,10Z)-hexadecadienoyl-containing glycerolipid into a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid." [EC:1.14.19.35]
comment: Introduces a cis double bond at a location 3 carbons away from the methyl end of the fatty acid. Acts on all 16:2- or 18:2-containing chloroplast membrane lipids, including phosphatidylglycerol, monogalactosyldiacylglycerol, digalactosyldiaclyglycerol, and sulfoquinovosyldiacylglycerol.
synonym: "linolenate delta15 desaturase activity" EXACT []
xref: EC:1.14.19.35
xref: MetaCyc:RXN-9667
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0102995
name: angelicin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: columbianetin + NADPH + O2 + H+ = angelicin + acetone + NADP + 2 H2O." [EC:1.14.14.148, GOC:pz]
xref: EC:1.14.14.148
xref: MetaCyc:RXN-9689
xref: RHEA:27481
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102996
name: obsolete beta,beta digalactosyldiacylglycerol galactosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol = a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 1,4-alpha-glucan branching enzyme activity ; GO:0003844.
is_obsolete: true
replaced_by: GO:0003844

[Term]
id: GO:0102997
name: obsolete progesterone 5beta- reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + progesterone + NADPH = 5beta-pregnane-3,20-dione + NADP." [GOC:pz]
comment: The reason for obsoletion is that a leaf term should not refer to partial EC.
is_obsolete: true
replaced_by: GO:0047787

[Term]
id: GO:0102998
name: 4-sulfomuconolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O = maleylacetate + sulfite + 2 H+." [EC:3.1.1.92]
xref: EC:3.1.1.92
xref: MetaCyc:RXN-9733
xref: RHEA:33711
xref: UM-BBD_reactionID:r0583
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102999
name: obsolete UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene = 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103000
name: obsolete UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene = 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103001
name: dimethylsulfoxide oxygenase activity
namespace: molecular_function
def: "Catalysis of the reactions: dimethyl sulfoxide + H+ + NADH + O2 = dimethyl sulfone + H2O + NAD+ and dimethyl sulfide + H+ + NADH + O2 = dimethyl sulfoxide + H2O + NAD+." [EC:1.14.13.245, PMID:9345770]
synonym: "assimilatory dimethylsulfide S-monooxygenase activity" EXACT []
xref: EC:1.14.13.245
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103002
name: 16-hydroxypalmitate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 16-hydroxypalmitate + NADP = H+ + 16-oxo-palmitate + NADPH." [GOC:pz]
xref: MetaCyc:RXN-9802
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0103003
name: obsolete oleate peroxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: oleate + a lipid hydroperoxide = 9,10-epoxystearate + a lipid alcohol." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0103004
name: 9,10-epoxystearate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH = 9,10-epoxy-18-hydroxystearate + H2O + NADP." [GOC:pz]
xref: MetaCyc:RXN-9805
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103005
name: obsolete 9,10-epoxystearate hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 9,10-epoxystearate + H2O = (9R,10S)-dihydroxystearate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0103006
name: 9,10-dihydroxystearate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH = 9,10,18-trihydroxystearate + H2O + NADP." [GOC:pz]
xref: MetaCyc:RXN-9807
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103007
name: indole-3-acetate carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine." [EC:2.1.1.278, GOC:pz]
xref: EC:2.1.1.278
xref: MetaCyc:RXN-9825
xref: RHEA:36131
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0103008
name: obsolete 4-chloro-2-methylphenoxyacetate oxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0103009
name: obsolete 3-chlorotoluene monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 = 3-chlorobenzyl alcohol + NAD + H2O." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0103010
name: obsolete gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0045543

[Term]
id: GO:0103011
name: mannosylfructose-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate = mannosylfructose-phosphate + GDP." [EC:2.4.1.246, GOC:pz]
xref: EC:2.4.1.246
xref: MetaCyc:RXN-9935
xref: RHEA:26039
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0103012
name: ferredoxin-thioredoxin reductase activity
namespace: molecular_function
alt_id: GO:0030385
def: "Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide." [GOC:pz, PMID:14769790, RHEA:42336]
synonym: "ferredoxin:thioredoxin reductase activity" EXACT []
xref: EC:1.8.7.2
xref: MetaCyc:RXN-9944
xref: RHEA:42336
is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0103014
name: obsolete beta-keto ester reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ethyl-(2R)-methyl-(3S)-hydroxybutanoate + NADP = ethyl-2-methylacetoacetate + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as 2,5-didehydrogluconate reductase activity ; GO:0050580.
is_obsolete: true
consider: GO:0050580

[Term]
id: GO:0103015
name: 4-amino-4-deoxy-L-arabinose transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate." [EC:2.4.2.43, GOC:pz]
xref: EC:2.4.2.43
xref: MetaCyc:RXN0-2001
xref: RHEA:35371
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0103016
name: tRNA-uridine 2-sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H+ + L-cysteinyl-[protein]." [RHEA:47032]
synonym: "tRNA-specific 2-thiouridylase activity" RELATED []
synonym: "tRNA-uracil-34 sulfurtransferase activity" RELATED []
xref: EC:2.8.1.13
xref: MetaCyc:RXN0-2023
xref: RHEA:47032
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0103020
name: 1-deoxy-D-xylulose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-deoxy-D-xylulose + ATP = H+ + 1-deoxy-D-xylulose 5-phosphate + ADP." [GOC:pz, PMID:11168365, PMID:16920870]
xref: MetaCyc:RXN0-382
xref: RHEA:27990
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0103023
name: ITPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate." [GOC:pz, PMID:16216582, RHEA:28330]
xref: EC:3.6.1.73
xref: MetaCyc:RXN0-5073
xref: RHEA:28330
is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity

[Term]
id: GO:0103026
name: fructose-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate." [RHEA:35603]
xref: MetaCyc:RXN0-5186
xref: RHEA:35603
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0103027
name: obsolete FMN phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate." [GOC:pz]
comment: The reason for obsoletion is that this term is equivalent to GO:0090711 FMN hydrolase activity.
is_obsolete: true
replaced_by: GO:0090711

[Term]
id: GO:0103028
name: murein hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide." [EC:4.2.2.-, GOC:pz]
xref: MetaCyc:RXN0-5190
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0103030
name: obsolete ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD." [GOC:pz]
comment: This term was obsoleted because this activity is not known to be physiological significant, see PMID:16813561 .
is_obsolete: true

[Term]
id: GO:0103031
name: L-Ala-D/L-Glu epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction:L-alanyl-L-glutamate = L-alanyl-D-glutamate." [RHEA:28394]
xref: EC:5.1.1.20
xref: MetaCyc:RXN0-5228
xref: RHEA:28394
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0103032
name: obsolete tartronate semialdehyde reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-glycerate + NAD = H+ + 2-hydroxy-3-oxopropanoate + NADH." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-hydroxy-3-oxopropionate reductase activity ; GO:0008679.
is_obsolete: true
replaced_by: GO:0008679

[Term]
id: GO:0103033
name: beta-galactosidase activity (lactose isomerization)
namespace: molecular_function
def: "Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose." [EC:5.4.1.-, GOC:pz]
xref: MetaCyc:RXN0-5363
is_a: GO:0016867 ! intramolecular acyltransferase activity

[Term]
id: GO:0103035
name: obsolete NADPH:methyl-1,4-benzoquinone oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of NADPH dehydrogenase (quinone) activity ;  GO:0008753.
is_obsolete: true
replaced_by: GO:0008753

[Term]
id: GO:0103036
name: NADH:menaquinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5 H+ + NADH + a menaquinone = 4 H+ + NAD + a menaquinol." [GOC:pz]
xref: MetaCyc:RXN0-5388
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0103037
name: L-glyceraldehyde 3-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH." [GOC:pz, PMID:18620424]
xref: MetaCyc:RXN0-5410
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0103039
name: protein methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor." [EC:2.8.4.4, GOC:pz]
xref: EC:2.8.4.4
xref: MetaCyc:RXN0-6366
xref: RHEA:37087
is_a: GO:0035596 ! methylthiotransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0103040
name: aldose sugar dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor." [GOC:pz, MetaCyc:RXN0-6371, PMID:16864586]
comment: https://github.com/geneontology/go-ontology/issues/28942
xref: MetaCyc:RXN0-6371
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0103041
name: thiosulfate-thioredoxin sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin." [EC:2.8.1.-, GOC:pz]
xref: MetaCyc:RXN0-6385
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0103042
name: 4-hydroxy-L-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-threonine = glycolaldehyde + glycine." [GOC:pz, RHEA:28779]
xref: MetaCyc:RXN0-6563
xref: RHEA:28779
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0103043
name: phosphoribosyl 1,2-cyclic phosphate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H+." [EC:3.1.4.55]
synonym: "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity" RELATED []
xref: EC:3.1.4.55
xref: MetaCyc:RXN0-6710
xref: RHEA:34795
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0103044
name: obsolete ribosomal protein S6 glutamate-glutamate ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0103045
name: L-methionine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+." [RHEA:44144]
xref: MetaCyc:RXN0-6948
xref: RHEA:44144
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0103046
name: obsolete alanylglutamate dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-alanyl-L-glutamate + H2O = L-alanine + L-glutamate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of dipeptidase activity ; GO:0016805.
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0103047
name: obsolete methyl beta-D-glucoside 6-phosphate glucohydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 6-phospho-beta-glucosidase activity ; GO:0008706.
is_obsolete: true
replaced_by: GO:0008706

[Term]
id: GO:0103048
name: obsolete tRNA m2A37 methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as tRNA (adenine(37)-C2-)-methyltransferase activity ; GO:0002935.
is_obsolete: true
replaced_by: GO:0002935

[Term]
id: GO:0103050
name: obsolete isobutyraldehyde reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isobutanol + NADP = isobutyraldehyde + NADPH + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of alcohol dehydrogenase (NADP+) activity; GO:0008106.
is_obsolete: true
replaced_by: GO:0008106

[Term]
id: GO:0103054
name: obsolete gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate = gibberellin A15 + carbon dioxide + succinate." [GOC:pz]
comment: This term was obsoleted because it represents the same activity as gibberellin 20-oxidase activity ; GO:0045544.
is_obsolete: true
replaced_by: GO:0045544

[Term]
id: GO:0103055
name: obsolete gibberellin A15, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 = gibberellin A24 + succinate + carbon dioxide + H2O." [GOC:pz]
comment: This term was obsoleted because it is an intermediate in gibberellin 20-oxidase activity GO:0045544, see PMID:32652020.
is_obsolete: true
replaced_by: GO:0045544

[Term]
id: GO:0103056
name: obsolete gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate = gibberellin A44 diacid + carbon dioxide + succinate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of gibberellin 20-oxidase activity ; GO:0045544.
is_obsolete: true
replaced_by: GO:0045544

[Term]
id: GO:0103057
name: obsolete gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate = H+ + gibberellin A20 + 2 carbon dioxide + succinate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0045544

[Term]
id: GO:0103058
name: obsolete kaempferol 3-glucoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose = kaempferol-3-glucoside-7-rhamnoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103059
name: obsolete UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose = H+ + kaempferol-3-rhamnoside + UDP(3-)." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103060
name: obsolete kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose = kaempferol-3-rhamnoside-7-rhamnoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103061
name: obsolete trans-methoxy-C60-meroacyl-AMP ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] = diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]." [GOC:pz, PMID:15042094]
comment: This term was obsoleted because it represents a specific subtrate of long-chain fatty acid-CoA ligase activity ; GO:0004467.
is_obsolete: true
replaced_by: GO:0004467

[Term]
id: GO:0103062
name: obsolete cis-keto-C60-meroacyl-AMP ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] = diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of long-chain fatty acid [acyl-carrier-protein] ligase activity ; GO:0008922.
is_obsolete: true
replaced_by: GO:0008922

[Term]
id: GO:0103063
name: obsolete trans-keto-C61-meroacyl-AMP ligase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] = diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of long-chain fatty acid-CoA ligase activity ; GO:0004467.
is_obsolete: true
replaced_by: GO:0004467

[Term]
id: GO:0103064
name: inositol phosphorylceramide mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+." [GOC:pz, RHEA:64596]
xref: EC:2.4.1.370
xref: MetaCyc:RXN3O-663
xref: RHEA:64596
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0103066
name: obsolete 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity ; GO:0000252.
is_obsolete: true
replaced_by: GO:0000252

[Term]
id: GO:0103067
name: obsolete 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity ; GO:0000252.
is_obsolete: true
replaced_by: GO:0000252

[Term]
id: GO:0103068
name: leukotriene C4 gamma-glutamyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid." [GOC:pz, PMID:1676842, PMID:9139674]
xref: EC:2.3.2.2
xref: MetaCyc:RXN66-336
is_a: GO:0016755 ! aminoacyltransferase activity

[Term]
id: GO:0103069
name: 17-hydroxyprogesterone 21-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:50308]
xref: MetaCyc:RXN66-356
xref: RHEA:50308
is_a: GO:0004509 ! steroid 21-monooxygenase activity

[Term]
id: GO:0103071
name: obsolete 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA = formyl-CoA + a 2-methyl branched 2,3,4-saturated fatty aldehyde." [EC:4.1.-.-, GOC:pz]
comment: This term was obsoleted because it represents the same activity as 2-hydroxyacyl-CoA lyase activity ; GO:0106359.
is_obsolete: true
replaced_by: GO:0106359

[Term]
id: GO:0103072
name: straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde." [EC:4.1.-.-, GOC:pz]
xref: MetaCyc:RXN66-475
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0103074
name: glucose-6-phosphate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate." [GOC:pz, RHEA:37547]
xref: EC:1.1.1.361
xref: MetaCyc:RXN8J2-136
xref: RHEA:37547
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0103075
name: indole-3-pyruvate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ = indole-3-acetate + carbon dioxide + NADP + H2O." [EC:1.14.13.168, GOC:pz]
xref: EC:1.14.13.168
xref: MetaCyc:RXNDQC-2
xref: RHEA:34331
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103077
name: obsolete quercetin 3-glucoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose = quercetin-3-O-glucoside-7-O-rhamnoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103078
name: obsolete quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose = quercetin-3-rhamnoside-7-rhamnoside + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103079
name: obsolete 2-(3'-methylthio)propylmalate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O = H+ + 2-(3-methylthiopropyl)malate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of methylthioalkylmalate synthase activity ; GO:0010177.
is_obsolete: true
replaced_by: GO:0010177

[Term]
id: GO:0103080
name: obsolete methylthiopropylmalate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) = 3-(3'-methylthio)propylmalate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-(omega-methylthio)alkylmalate dehydratase activity ; GO:0120528.
is_obsolete: true
replaced_by: GO:0120528

[Term]
id: GO:0103081
name: obsolete methylthiopropylmalate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(3'-methylthio)propylmalate = H+ + 2-oxo-6-methylthiohexanoate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-isopropylmalate dehydrogenase activity ; GO:0003862.
is_obsolete: true
replaced_by: GO:0003862

[Term]
id: GO:0103082
name: obsolete 2-(4'-methylthio)butylmalate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O = H+ + 2-(4'-methylthio)butylmalate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of methylthioalkylmalate synthase activity ; GO:0010177.
is_obsolete: true
replaced_by: GO:0010177

[Term]
id: GO:0103083
name: obsolete methylthiobutylmalate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-(4'-methylthio)butylmalate = 3-(4'-methylthio)butylmalate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-(omega-methylthio)alkylmalate dehydratase activity ; GO:0120528.
is_obsolete: true
replaced_by: GO:0120528

[Term]
id: GO:0103084
name: obsolete methylthiobutylmalate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(4'-methylthio)butylmalate = H+ + 2-oxo-7-methylthioheptanoate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-isopropylmalate dehydrogenase activity ; GO:0003862
is_obsolete: true
replaced_by: GO:0003862

[Term]
id: GO:0103085
name: obsolete 2-(5'-methylthio)pentylmalate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O = H+ + 2-(5'-methylthio)pentylmalate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of methylthioalkylmalate synthase activity ; GO:0010177.
is_obsolete: true
replaced_by: GO:0010177

[Term]
id: GO:0103086
name: obsolete methylthiopentylmalate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-(5'-methylthio)pentylmalate = 3-(5'-methylthio)pentylmalate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-(omega-methylthio)alkylmalate dehydratase activity ; GO:0120528.
is_obsolete: true
replaced_by: GO:0120528

[Term]
id: GO:0103087
name: obsolete methylthiopentylmalate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(5'-methylthio)pentylmalate = H+ + 2-oxo-8-methylthiooctanoate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-isopropylmalate dehydrogenase activity ; GO:0003862.
is_obsolete: true
replaced_by: GO:0003862

[Term]
id: GO:0103088
name: obsolete 2-(6'-methylthio)hexylmalate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O = H+ + 2-(6'-methylthio)hexylmalate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of methylthioalkylmalate synthase activity ; GO:0010177.
is_obsolete: true
replaced_by: GO:0010177

[Term]
id: GO:0103089
name: obsolete methylthiohexylmalate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-(6'-methylthio)hexylmalate = 3-(6'-methylthio)hexylmalate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-(omega-methylthio)alkylmalate dehydratase activity ; GO:0120528.
is_obsolete: true
replaced_by: GO:0120528

[Term]
id: GO:0103090
name: obsolete methylthiohexylmalate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(6'-methylthio)hexylmalate = H+ + 2-oxo-9-methylthiononanoate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-isopropylmalate dehydrogenase activity ; GO:0003862.
is_obsolete: true
replaced_by: GO:0003862

[Term]
id: GO:0103091
name: obsolete 2-(7'-methylthio)heptylmalate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O = H+ + 2-(7'-methylthio)heptylmalate + coenzyme A." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of methylthioalkylmalate synthase activity ; GO:0010177.
is_obsolete: true
replaced_by: GO:0010177

[Term]
id: GO:0103092
name: obsolete methylthioalkylmalate isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-(7'-methylthio)heptylmalate = 3-(7'-methylthio)heptylmalate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 2-(omega-methylthio)alkylmalate dehydratase activity ; GO:0120528.
is_obsolete: true
replaced_by: GO:0120528

[Term]
id: GO:0103093
name: obsolete methylthioalkylmalate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-(7'-methylthio)heptylmalate = H+ + 2-oxo-10-methylthiodecanoate + carbon dioxide." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of 3-isopropylmalate dehydrogenase activity ; GO:0003862.
is_obsolete: true
replaced_by: GO:0003862

[Term]
id: GO:0103096
name: obsolete CYP79F1 dihomomethionine monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP." [GOC:pz]
comment: This term was obsoeted because it represents a substep of homomethionine N-monooxygenase activity ; GO:0120526.
is_obsolete: true
replaced_by: GO:0120526

[Term]
id: GO:0103097
name: obsolete CYP79F1 trihomomethionine monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime." [GOC:pz]
comment: This term was obsoeted because it represents a substep of homomethionine N-monooxygenase activity ; GO:0120526.
is_obsolete: true
replaced_by: GO:0120526

[Term]
id: GO:0103098
name: obsolete CYP79F1 tetrahomomethionine monooxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH = 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true
replaced_by: GO:0120526

[Term]
id: GO:0103099
name: obsolete UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate = H+ + 4-methylthiobutyldesulfoglucosinolate + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiohydroximate beta-D-glucosyltransferase activity ; GO:0047251.
is_obsolete: true
replaced_by: GO:0047251

[Term]
id: GO:0103100
name: obsolete UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate = H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-)." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiohydroximate beta-D-glucosyltransferase activity ; GO:0047251.
is_obsolete: true
replaced_by: GO:0047251

[Term]
id: GO:0103101
name: obsolete UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate = H+ + 6-methylthiohexyldesulfoglucosinolate + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiohydroximate beta-D-glucosyltransferase activity ; GO:0047251.
is_obsolete: true
replaced_by: GO:0047251

[Term]
id: GO:0103102
name: obsolete UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate = H+ + 7-methylthioheptyldesulfoglucosinolate + UDP." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiohydroximate beta-D-glucosyltransferase activity ; GO:0047251.
is_obsolete: true
replaced_by: GO:0047251

[Term]
id: GO:0103103
name: obsolete UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate = 8-methylthiooctyldesulfoglucosinolate + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of thiohydroximate beta-D-glucosyltransferase activity ; GO:0047251.
is_obsolete: true
replaced_by: GO:0047251

[Term]
id: GO:0103104
name: obsolete 6-methylthiohexyldesulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate = adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate of aliphatic desulfoglucosinolate sulfotransferase activity ; GO:0120527.
is_obsolete: true
replaced_by: GO:0120527

[Term]
id: GO:0103105
name: obsolete 2-oxo-6-methylthiohexanoate aminotransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid = dihomomethionine + a 2-oxo carboxylate." [GOC:pz]
comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
is_obsolete: true

[Term]
id: GO:0103106
name: obsolete brassinolide 23-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose = brassinolide-23-O-glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103107
name: obsolete castasterone 23-O-glucosyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: castasterone + UDP-alpha-D-glucose = castasterone-23-O-glucoside + UDP + H+." [GOC:pz]
comment: This term was obsoleted because it represents a specific substrate.
is_obsolete: true

[Term]
id: GO:0103111
name: protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)." [RHEA:49240]
synonym: "D-glucosamine PTS permease activity" EXACT []
synonym: "N-acetyl-D-glucosamine PTS permease activity" EXACT [EC:2.7.1.193]
xref: EC:2.7.1.193
xref: RHEA:49240
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0103113
name: obsolete glucosyl-oleandomycin-exporting ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glucosyl-oleandomycin + ATP + H2O = glucosyl-oleandomycin + ADP + hydrogenphosphate + H+." [EC:3.6.3.-, GOC:pz]
comment: This term was obsoleted because it represents a substrate-specific version of the general term GO:0008559 ATPase-coupled xenobiotic transmembrane transporter activity.
is_obsolete: true

[Term]
id: GO:0103116
name: ABC-type D-galactofuranose transporter
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O = alpha-D-galactofuranose + hydrogenphosphate + ADP + H+." [GOC:pz, PMID:19744923, RHEA:61716]
synonym: "alpha-D-galactofuranose transporter activity" EXACT []
synonym: "ATP-dependent alpha-D-galactofuranose transporter activity" EXACT []
synonym: "ATPase-coupled alpha-D-galactofuranose transporter activity" RELATED []
xref: EC:7.5.2.9
xref: MetaCyc:TRANS-RXN-333
xref: RHEA:61716
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0015407 ! ABC-type monosaccharide transporter activity

[Term]
id: GO:0103117
name: UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate." [GOC:pz, RHEA:67816]
xref: EC:3.5.1.108
xref: MetaCyc:UDPACYLGLCNACDEACETYL-RXN
xref: RHEA:67816
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0103118
name: UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
namespace: molecular_function
alt_id: GO:0043764
def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] = UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]." [EC:2.3.1.191, GOC:pz]
synonym: "UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" RELATED []
xref: EC:2.3.1.191
xref: MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN
xref: RHEA:17817
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0104004
name: cellular response to environmental stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos]
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0104005
name: obsolete hijacked molecular function
namespace: molecular_function
def: "OBSOLETE. A function that was not selected for in the evolution of an organism, but arises from co-option by another organism, e.g. a human protein used as a virus receptor." [GOC:pdt]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0106001
name: intestinal hexose absorption
namespace: biological_process
def: "Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine." [GOC:hjd]
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0106002
name: mCRD-mediated mRNA stability complex
namespace: cellular_component
def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545]
comment: This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA.
synonym: "major coding region determinant of instability-mediated mRNA stability complex" EXACT []
synonym: "major coding region instability determinant-mediated mRNA stability complex" EXACT []
synonym: "major coding region instability determinant-poly(A)-bridging complex" EXACT []
synonym: "major coding-region determinant of instability - poly(A) tail-bridging complex" EXACT []
synonym: "mCRD-poly(A)-bridging complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0106003
name: amyloid-beta complex
namespace: cellular_component
def: "Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease." [GOC:bhm, PMID:18568035]
comment: An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay).
synonym: "Abeta complex" EXACT []
synonym: "Abeta-derived diffusible ligand complex" NARROW []
synonym: "ADDL complex" NARROW []
synonym: "amyloid beta complex" EXACT []
synonym: "amyloid beta dimer" NARROW []
synonym: "amyloid beta heterodimer" NARROW []
synonym: "amyloid beta heterooligomer" NARROW []
synonym: "amyloid beta heterotrimer" NARROW []
synonym: "amyloid beta homodimer" NARROW []
synonym: "amyloid beta homooligomer" NARROW []
synonym: "amyloid beta homotrimer" NARROW []
synonym: "amyloid beta oligomer" NARROW []
synonym: "amyloid beta trimer" NARROW []
synonym: "amyloid-beta protein 40 complex" NARROW []
synonym: "amyloid-beta protein 40/42 complex" NARROW []
synonym: "amyloid-beta protein 42 complex" NARROW []
synonym: "beta amyloid complex" EXACT []
synonym: "beta-amyloid complex" EXACT []
synonym: "betaA complex" EXACT []
synonym: "heterodimer of amyloid beta protein" NARROW []
synonym: "heterooligomer of amyloid beta protein" NARROW []
synonym: "heterotrimer of amyloid beta protein" NARROW []
synonym: "homodimer of amyloid beta protein" NARROW []
synonym: "homooligomer of amyloid beta protein" NARROW []
synonym: "homotrimer of amyloid beta protein" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0106004
name: tRNA (guanine-N7)-methylation
namespace: biological_process
def: "The process whereby a guanine in a tRNA is methylated at the N7 position of guanine." [GOC:hjd, PMID:17382321]
is_a: GO:0030488 ! tRNA methylation
is_a: GO:0036265 ! RNA (guanine-N7)-methylation

[Term]
id: GO:0106005
name: RNA 5'-cap (guanine-N7)-methylation
namespace: biological_process
def: "The process whereby a guanine in 5-cap is methylated at the N7 position of guanine." [GOC:hjd]
is_a: GO:0036265 ! RNA (guanine-N7)-methylation
relationship: part_of GO:0009452 ! 7-methylguanosine RNA capping

[Term]
id: GO:0106006
name: cytoskeletal protein-membrane anchor activity
namespace: molecular_function
alt_id: GO:0140362
def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location." [PMID:25736293, PMID:30840879]
synonym: "BAR domain adaptor" NARROW []
synonym: "cytoskeletal protein membrane adaptor" BROAD []
synonym: "cytoskeletal protein membrane anchor activity" BROAD []
synonym: "cytoskeletal protein membrane tether activity" BROAD []
synonym: "cytoskeletal protein to membrane recruiting activity" EXACT []
synonym: "cytoskeletal protein-membrane adaptor activity" BROAD []
synonym: "F-BAR domain adaptor" NARROW []
synonym: "membrane-cytoskeletal protein anchor activity" BROAD []
synonym: "membrane-cytoskeletal protein tether activity" BROAD []
synonym: "microtubule cortical anchor activity" NARROW []
is_a: GO:0008093 ! cytoskeletal anchor activity
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0106007
name: microtubule anchoring at cell cortex of cell tip
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex." [GOC:mah, PMID:25736293]
is_a: GO:0034453 ! microtubule anchoring

[Term]
id: GO:0106008
name: 2-oxoglutaramate amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3." [EC:3.5.1.111, PMID:21288482]
xref: EC:3.5.1.111
xref: RHEA:32963
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0106009
name: (4S)-4-hydroxy-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Specific for the (4S) enantiomer of 4-hydroxy-2-oxoglutarate." [PMID:1098660, PMID:1339418, RHEA:35639]
xref: EC:4.1.3.42
xref: RHEA:35639
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0106011
name: regulation of protein localization to medial cortex
namespace: biological_process
def: "Any process that regulates the localization of a protein to the medial cortex." [GOC:hjd]
is_a: GO:1901900 ! regulation of protein localization to cell division site
is_a: GO:1904776 ! regulation of protein localization to cell cortex
relationship: regulates GO:0071574 ! protein localization to medial cortex

[Term]
id: GO:0106012
name: positive regulation of protein localization to medial cortex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex." [GOC:hjd, PMID:19474789]
is_a: GO:0106011 ! regulation of protein localization to medial cortex
is_a: GO:1904778 ! positive regulation of protein localization to cell cortex
relationship: positively_regulates GO:0071574 ! protein localization to medial cortex

[Term]
id: GO:0106013
name: negative regulation of protein localization to cell cortex of cell tip
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip." [GOC:vw, PMID:19474792]
is_a: GO:1990895 ! regulation of protein localization to cell cortex of cell tip

[Term]
id: GO:0106014
name: regulation of inflammatory response to wounding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:1903034 ! regulation of response to wounding
relationship: regulates GO:0090594 ! inflammatory response to wounding

[Term]
id: GO:0106015
name: negative regulation of inflammatory response to wounding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0106014 ! regulation of inflammatory response to wounding
is_a: GO:1903035 ! negative regulation of response to wounding
relationship: negatively_regulates GO:0090594 ! inflammatory response to wounding

[Term]
id: GO:0106016
name: positive regulation of inflammatory response to wounding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0106014 ! regulation of inflammatory response to wounding
is_a: GO:1903036 ! positive regulation of response to wounding
relationship: positively_regulates GO:0090594 ! inflammatory response to wounding

[Term]
id: GO:0106017
name: phosphatidylinositol-3,4-bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd]
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity

[Term]
id: GO:0106018
name: phosphatidylinositol-3,5-bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd]
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity

[Term]
id: GO:0106019
name: phosphatidylinositol-4,5-bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd]
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity

[Term]
id: GO:0106020
name: regulation of vesicle docking
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle docking." [PMID:22810233]
synonym: "regulation of vesicle to membrane docking" EXACT []
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0048278 ! vesicle docking

[Term]
id: GO:0106021
name: negative regulation of vesicle docking
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking." [PMID:22810233]
synonym: "negative regulation of vesicle to membrane docking" EXACT []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0106020 ! regulation of vesicle docking
relationship: negatively_regulates GO:0048278 ! vesicle docking

[Term]
id: GO:0106022
name: positive regulation of vesicle docking
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle docking." [PMID:22810233]
synonym: "positive regulation of vesicle to membrane docking" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0106020 ! regulation of vesicle docking
relationship: positively_regulates GO:0048278 ! vesicle docking

[Term]
id: GO:0106023
name: regulation of pupariation
namespace: biological_process
def: "Any process that modulates the onset of pupariation." [PMID:26510564]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0035073 ! pupariation

[Term]
id: GO:0106024
name: negative regulation of pupariation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of onset of pupariation." [PMID:26510564]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0106023 ! regulation of pupariation
relationship: negatively_regulates GO:0035073 ! pupariation

[Term]
id: GO:0106025
name: positive regulation of pupariation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of onset of pupariation." [GOC:hjd]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0106023 ! regulation of pupariation
relationship: positively_regulates GO:0035073 ! pupariation

[Term]
id: GO:0106026
name: Gly-tRNA(Ala) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala)." [PMID:28362257]
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0106027
name: neuron projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0106028
name: neuron projection retraction
namespace: biological_process
def: "The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:aruk, GOC:bc, PMID:11585923]
synonym: "neuron projection disassembly" EXACT []
is_a: GO:0106027 ! neuron projection organization

[Term]
id: GO:0106029
name: tRNA pseudouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:11095668]
synonym: "transfer ribonucleate pseudouridine synthetase activity" EXACT []
synonym: "transfer RNA pseudouridine synthetase activity" EXACT []
synonym: "tRNA-pseudouridine synthase activity" EXACT []
synonym: "tRNA-uridine isomerase activity" EXACT []
synonym: "tRNA-uridine uracilmutase activity" EXACT []
xref: RHEA:54572
is_a: GO:0009982 ! pseudouridine synthase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0106030
name: neuron projection fasciculation
namespace: biological_process
def: "The collection of neuronal projections into a bundle of rods, known as a fascicle." [GOC:aruk, GOC:bc., PMID:12761826]
is_a: GO:0031175 ! neuron projection development

[Term]
id: GO:0106032
name: snRNA pseudouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine in snRNA = pseudouridine in snRNA. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:28432181, RHEA:51124]
xref: RHEA:51124
is_a: GO:0009982 ! pseudouridine synthase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0106033
name: spine synapse
namespace: cellular_component
def: "A type of synapse occurring between an axon and a dendritic spine." [PMID:15028757]
synonym: "dendritic spine synapse" EXACT []
is_a: GO:0032279 ! asymmetric synapse

[Term]
id: GO:0106034
name: protein maturation by [2Fe-2S] cluster transfer
namespace: biological_process
def: "The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]
is_a: GO:0097428 ! protein maturation by iron-sulfur cluster transfer

[Term]
id: GO:0106035
name: protein maturation by [4Fe-4S] cluster transfer
namespace: biological_process
def: "The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]
is_a: GO:0097428 ! protein maturation by iron-sulfur cluster transfer

[Term]
id: GO:0106036
name: assembly of apicomedial cortex actomyosin
namespace: biological_process
def: "A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin." [PMID:28263180]
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0031032 ! actomyosin structure organization

[Term]
id: GO:0106037
name: apicomedial cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell." [PMID:23831726, PMID:28263180]
synonym: "medioapical cortex" EXACT []
is_a: GO:0045179 ! apical cortex

[Term]
id: GO:0106038
name: obsolete vesicle assembly
namespace: biological_process
def: "OBSOLETE. A process carried out at the cellular level, which results in the arrangement of constituent parts of a vesicle. Vesicle assembly begins with membrane bending (GO:0097753) and ends with fusion of the vesicle after vesicle scission (GO:0099050)." [GOC:aruk, GOC:bc, PMID:25898166]
comment: This term was made obsolete because it is an exact synonym of 'membrane budding'.
synonym: "vesicle biosynthesis" EXACT []
synonym: "vesicle formation" EXACT []
is_obsolete: true

[Term]
id: GO:0106039
name: obsolete vesicle fusion involved in vesicle assembly
namespace: biological_process
def: "OBSOLETE. A process carried out at the cellular level, which is the final step in vesicle assembly. Vesicle fusion occurs when a newly assembled vesicle closes up, following vesicle vesicle scission (GO:0099050)." [GOC:aruk, GOC:bc, PMID:25898166]
comment: This term was made obsolete becausethat 'fusion' should only be used for two membranes getting joined together, whereas in this case it would be one membrane 'closing/sealing up'.
is_obsolete: true

[Term]
id: GO:0106040
name: regulation of GABA-A receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036]
subset: gocheck_obsoletion_candidate
is_a: GO:0010469 ! regulation of signaling receptor activity

[Term]
id: GO:0106041
name: obsolete positive regulation of GABA-A receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0106042
name: obsolete negative regulation of GABA-A receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0106044
name: guanine deglycation
namespace: biological_process
def: "The removal of a sugar or dicarbonyl from a glycated guanine." [PMID:28596309]
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0106045
name: guanine deglycation, methylglyoxal removal
namespace: biological_process
def: "The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine." [PMID:28596309]
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0106044 ! guanine deglycation
is_a: GO:0140041 ! cellular detoxification of methylglyoxal

[Term]
id: GO:0106046
name: guanine deglycation, glyoxal removal
namespace: biological_process
def: "The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine." [PMID:28596309]
is_a: GO:0106044 ! guanine deglycation

[Term]
id: GO:0106047
name: polyamine deacetylation
namespace: biological_process
def: "The modification of acetylpolyamine by the removal of acetyl groups." [PMID:28516954]
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0098732 ! macromolecule deacylation

[Term]
id: GO:0106048
name: spermidine deacetylation
namespace: biological_process
def: "The modification of acetylspermadine by the removal of acetyl groups." [PMID:28516954]
synonym: "N8-acetylspermidine deacetylation" EXACT []
is_a: GO:0008216 ! spermidine metabolic process
is_a: GO:0106047 ! polyamine deacetylation

[Term]
id: GO:0106049
name: regulation of cellular response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress." [PMID:10398679]
is_a: GO:0047484 ! regulation of response to osmotic stress
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0106050
name: tRNA 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide." [PMID:17242307]
xref: Reactome:R-HSA-6788668 "TRMT13 2'-O-methylates adenosine-4 in tRNA"
xref: Reactome:R-HSA-6788684 "TRMT13 2'-O-methylates cytidine-4 in tRNA"
xref: Reactome:R-HSA-9024159 "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)"
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity

[Term]
id: GO:0106054
name: obsolete tRNA-uracil-34 sulfurtransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [PMID:12549933, PMID:16387657]
comment: The reason for obsoletion is that this term is equivalent to GO:0103016 tRNA-uridine 2-sulfurtransferase activity.
synonym: "tRNA U34 2-thiouridylase" EXACT []
synonym: "tRNA U34 thiol-transferase activity" EXACT []
synonym: "tRNA-specific 2-thiouridylase" RELATED []
is_obsolete: true
replaced_by: GO:0103016

[Term]
id: GO:0106055
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase complex
namespace: cellular_component
def: "A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bhm, PMID:21700223]
comment: An example is MNL1 (P38888) in Saccharomyces cerevisiae. PMID:19124653 (by physical interaction evidence).
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005788 ! endoplasmic reticulum lumen

[Term]
id: GO:0106056
name: regulation of calcineurin-mediated signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204]
is_a: GO:0050848 ! regulation of calcium-mediated signaling
relationship: regulates GO:0097720 ! calcineurin-mediated signaling

[Term]
id: GO:0106057
name: negative regulation of calcineurin-mediated signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204]
is_a: GO:0050849 ! negative regulation of calcium-mediated signaling
is_a: GO:0106056 ! regulation of calcineurin-mediated signaling
relationship: negatively_regulates GO:0097720 ! calcineurin-mediated signaling

[Term]
id: GO:0106058
name: positive regulation of calcineurin-mediated signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:0106056 ! regulation of calcineurin-mediated signaling
relationship: positively_regulates GO:0097720 ! calcineurin-mediated signaling

[Term]
id: GO:0106059
name: tRNA (cytidine(56)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA." [RHEA:42968]
synonym: "tRNA (cytidine 56-2'-O)-methyltransferase activity" EXACT []
xref: EC:2.1.1.206
xref: MetaCyc:RXN-11869
xref: RHEA:42968
is_a: GO:0016427 ! tRNA (cytidine) methyltransferase activity

[Term]
id: GO:0106060
name: regulation of exit from meiosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exit from mitosis." [GOC:al, PMID:11493649]
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
relationship: regulates GO:1990947 ! exit from meiosis

[Term]
id: GO:0106061
name: negative regulation of exit from meiosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis." [GOC:al, PMID:11493649]
is_a: GO:0106060 ! regulation of exit from meiosis
is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition
relationship: negatively_regulates GO:1990947 ! exit from meiosis

[Term]
id: GO:0106062
name: positive regulation of exit from meiosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exit from meiosis." [GOC:al, PMID:11493649]
is_a: GO:0106060 ! regulation of exit from meiosis
is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition
relationship: positively_regulates GO:1990947 ! exit from meiosis

[Term]
id: GO:0106063
name: G protein-coupled folate receptor activity
namespace: molecular_function
def: "Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [PMID:26906738]
synonym: "G-protein coupled folate receptor activity" EXACT []
synonym: "G-protein coupled folic acid receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0106064
name: regulation of cobalamin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
relationship: regulates GO:0009235 ! cobalamin metabolic process

[Term]
id: GO:0106068
name: SUMO ligase complex
namespace: cellular_component
def: "A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex." [PMID:16847351]
synonym: "SUMO transferase complex" EXACT []
synonym: "SUMO-protein ligase complex" EXACT []
synonym: "Sumoylation complex" EXACT []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0106069
name: synapsis initiation complex
namespace: cellular_component
def: "A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase." [PMID:16847351]
is_a: GO:0106068 ! SUMO ligase complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0106070
name: regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489]
synonym: "regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway

[Term]
id: GO:0106071
name: positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489]
synonym: "positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
relationship: positively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway

[Term]
id: GO:0106072
name: negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489]
synonym: "negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
relationship: negatively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway

[Term]
id: GO:0106073
name: dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol." [GOC:ha, PMID:9597543]
xref: EC:2.4.1.256
xref: RHEA:29543
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0106074
name: aminoacyl-tRNA metabolism involved in translational fidelity
namespace: biological_process
def: "Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation." [GOC:hjd]
synonym: "aminoacyl-tRNA correction" RELATED []
synonym: "aminoacyl-tRNA editin" RELATED []
synonym: "aminoacyl-tRNA proofreading" RELATED []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0006450 ! regulation of translational fidelity

[Term]
id: GO:0106075
name: peptide N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide." [PMID:29211711]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0106076
name: peptide-lysine-N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide." [PMID:29211711]
is_a: GO:0106075 ! peptide N-succinyltransferase activity

[Term]
id: GO:0106077
name: obsolete histone succinylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by the addition of an succinyl group." [PMID:29211711]
comment: The reason for obsoletion is that this term represents a Molecular Function.
is_obsolete: true

[Term]
id: GO:0106078
name: histone succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone." [PMID:29211711]
is_a: GO:0106075 ! peptide N-succinyltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0106080
name: GATOR1 complex binding
namespace: molecular_function
def: "Binding to a GATOR1 complex." [PMID:28199306]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0106081
name: maltose import across plasma membrane
namespace: biological_process
def: "The directed movement of maltose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:11136464]
is_a: GO:0098704 ! carbohydrate import across plasma membrane
is_a: GO:1904981 ! maltose transmembrane transport

[Term]
id: GO:0106082
name: sucrose import across plasma membrane
namespace: biological_process
def: "The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:11136464]
is_a: GO:0098704 ! carbohydrate import across plasma membrane
is_a: GO:1904982 ! sucrose transmembrane transport

[Term]
id: GO:0106083
name: nuclear membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the nuclear membrane." [GOC:lnp, PMID:28356353]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0106084
name: mitotic nuclear membrane microtubule tethering complex
namespace: cellular_component
def: "A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane." [GOC:lnp, PMID:28356353]
comment: In S. cerevisae Mps2-Bpb1 is the membrane anchor sub complex and Spc29 is the spindle pole body linker molecule.
synonym: "Mps2-Bbp1-Spc29 complex" RELATED []
synonym: "nuclear membrane mitotic spindle pole body tethering complex" EXACT []
is_a: GO:0106094 ! nuclear membrane microtubule tethering complex

[Term]
id: GO:0106088
name: regulation of cell adhesion involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis

[Term]
id: GO:0106089
name: negative regulation of cell adhesion involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325]
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0106088 ! regulation of cell adhesion involved in sprouting angiogenesis
is_a: GO:1903671 ! negative regulation of sprouting angiogenesis
relationship: negatively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis

[Term]
id: GO:0106090
name: positive regulation of cell adhesion involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325]
is_a: GO:0045785 ! positive regulation of cell adhesion
is_a: GO:0106088 ! regulation of cell adhesion involved in sprouting angiogenesis
relationship: positively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis

[Term]
id: GO:0106091
name: glial cell projection elongation
namespace: biological_process
def: "The process of creating an elongation or projection from a glial cell." [GOC:ha, PMID:27131624]
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0021782 ! glial cell development

[Term]
id: GO:0106092
name: glial cell projection elongation involved in axon ensheathment
namespace: biological_process
def: "The extension of a glial cell process or projection to wrap around an axon." [GOC:ha, PMID:27131624]
is_a: GO:0008366 ! axon ensheathment
is_a: GO:0106091 ! glial cell projection elongation

[Term]
id: GO:0106093
name: EDS1 disease-resistance complex
namespace: cellular_component
def: "A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes." [GOC:bhm, PMID:11574472, PMID:16040633]
comment: Interacts with the R genes triggering ETI and systemic resistance.
synonym: "EDS1-PAD4 complex" NARROW []
synonym: "EDS1-PAD4-SAG101 complex" NARROW []
synonym: "EDS1-SAG101 complex" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0106094
name: nuclear membrane microtubule tethering complex
namespace: cellular_component
def: "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules." [GOC:vw, PMID:19225124]
is_a: GO:0106083 ! nuclear membrane protein complex

[Term]
id: GO:0106095
name: m7G(5')pppN diphosphatase complex
namespace: cellular_component
def: "A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide." [GOC:lnp, PMID:22985415, PMID:26258763]
synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase enzyme" EXACT []
synonym: "DCS1 decapping scavenger complex" EXACT []
synonym: "M(7)G(5')pppN pyrophosphatase enzyme" EXACT []
synonym: "m7G(5')pppN diphosphatase enzyme" EXACT []
synonym: "m7G(5')pppN pyrophosphatase enzyme" EXACT []
is_a: GO:1903293 ! phosphatase complex

[Term]
id: GO:0106096
name: response to ceramide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus." [PMID:18006463]
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0106097
name: cellular response to ceramide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus." [PMID:18006463]
is_a: GO:0071396 ! cellular response to lipid

[Term]
id: GO:0106098
name: NAGS/NAGK complex
namespace: cellular_component
def: "A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate." [GOC:lnp, PMID:11553611]
is_a: GO:0031248 ! protein acetyltransferase complex
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0098798 ! mitochondrial protein-containing complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0106099
name: 2-keto-3-deoxy-L-rhamnonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde." [EC:4.1.2.53, GOC:imk, PMID:18754683]
xref: EC:4.1.2.53
xref: RHEA:25784
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0106100
name: beta-pinacene synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene." [GOC:rjd, PMID:28696553]
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0106101
name: ER-dependent peroxisome localization
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum." [GOC:pga, PMID:19479899, PMID:26408931]
is_a: GO:0072662 ! protein localization to peroxisome

[Term]
id: GO:0106103
name: COPII vesicles tethering complex
namespace: cellular_component
def: "A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae." [GOC:lnp, PMID:21482742, PMID:9628863]
synonym: "Bug1-Grh1 complex" NARROW []
synonym: "GRASP65-GM130 complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0099023 ! vesicle tethering complex
relationship: part_of GO:0033106 ! cis-Golgi network membrane

[Term]
id: GO:0106104
name: regulation of glutamate receptor clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate receptor clustering." [GOC:ha, PMID:28455372]
is_a: GO:1903909 ! regulation of receptor clustering
relationship: regulates GO:0097688 ! glutamate receptor clustering

[Term]
id: GO:0106105
name: Ala-tRNA(Thr) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated ala-tRNA(thr)." [PMID:29410408]
synonym: "L-alanyl-tRNA(Thr) deacylase" EXACT []
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0106106
name: cold-induced thermogenesis
namespace: biological_process
def: "The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature." [PMID:27876809]
synonym: "CIT" RELATED []
is_a: GO:0001659 ! temperature homeostasis
is_a: GO:1990845 ! adaptive thermogenesis

[Term]
id: GO:0106107
name: regulation of (R)-mevalonic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (R)-mevalonic acid biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process

[Term]
id: GO:0106108
name: negative regulation of (R)-mevalonic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-mevalonic acid biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0106107 ! regulation of (R)-mevalonic acid biosynthetic process
relationship: negatively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process

[Term]
id: GO:0106109
name: positive regulation of (R)-mevalonic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (R)-mevalonic acid biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0106107 ! regulation of (R)-mevalonic acid biosynthetic process
relationship: positively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process

[Term]
id: GO:0106110
name: vomitoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats." [https://doi.org/10.1007/BF03356188, PMID:19333439, PMID:25680507, PMID:25758923, PMID:8637056]
synonym: "deoxynivalenol biosynthetic process" EXACT []
synonym: "DON biosynthetic process" EXACT []
synonym: "vomitoxin anabolism" EXACT []
synonym: "vomitoxin biosynthesis" EXACT []
synonym: "vomitoxin formation" EXACT []
synonym: "vomitoxin synthesis" EXACT []
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0106111
name: obsolete regulation of mitotic cohesin ssDNA (lagging strand) loading
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:0106112
name: obsolete negative regulation of mitotic cohesin ssDNA (lagging strand) loading
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:0106113
name: obsolete positive regulation of mitotic cohesin ssDNA (lagging strand) loading
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:0106114
name: obsolete regulation of mitotic cohesin dsDNA (leading strand) loading
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:0106115
name: obsolete negative regulation of mitotic cohesin dsDNA (leading strand) loading
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:0106116
name: obsolete positive regulation of mitotic cohesin dsDNA (leading strand) loading
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:0106117
name: acidocalcisome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an acidocalcisome. An acidocalcisome is an electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GO:0020022, PMID:25964650, PMID:26523947]
synonym: "acidocalcisome biogenesis" EXACT []
synonym: "acidocalcisome organisation" EXACT []
synonym: "acidocalcisome organization and biogenesis" EXACT []
synonym: "metachromatic granule organization" EXACT []
synonym: "polyphosphate vacuole organization" RELATED []
synonym: "volutin granule organization" EXACT []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0106118
name: regulation of sterol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310]
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0016126 ! sterol biosynthetic process

[Term]
id: GO:0106119
name: negative regulation of sterol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0106118 ! regulation of sterol biosynthetic process
relationship: negatively_regulates GO:0016126 ! sterol biosynthetic process

[Term]
id: GO:0106120
name: positive regulation of sterol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0106118 ! regulation of sterol biosynthetic process
relationship: positively_regulates GO:0016126 ! sterol biosynthetic process

[Term]
id: GO:0106121
name: positive regulation of cobalamin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341]
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0106064 ! regulation of cobalamin metabolic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
relationship: positively_regulates GO:0009235 ! cobalamin metabolic process

[Term]
id: GO:0106122
name: negative regulation of cobalamin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341]
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0106064 ! regulation of cobalamin metabolic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
relationship: negatively_regulates GO:0009235 ! cobalamin metabolic process

[Term]
id: GO:0106123
name: reservosome
namespace: cellular_component
def: "A large membrane-bound endocytic organelle present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and is defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. It is found at the posterior end of epimastigote forms of Trypanosoma cruzi, but absent in amastigotes and trypomastigotes." [GOC:ach, PMID:12204365, PMID:15521631, PMID:1845219, PMID:19288526, PMID:21818313, PMID:22425988]
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0106124
name: reservosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0106123 ! reservosome

[Term]
id: GO:0106125
name: reservosome matrix
namespace: cellular_component
def: "A matrix composed of planar membranes, vesicles and lipid inclusions within the reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0106123 ! reservosome

[Term]
id: GO:0106126
name: reservosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0106123 ! reservosome

[Term]
id: GO:0106128
name: negative regulation of store-operated calcium entry
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium entry." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642]
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:2001256 ! regulation of store-operated calcium entry
relationship: negatively_regulates GO:0002115 ! store-operated calcium entry

[Term]
id: GO:0106129
name: positive regulation of store-operated calcium entry
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of store-operated calcium entry." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642]
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:2001256 ! regulation of store-operated calcium entry
relationship: positively_regulates GO:0002115 ! store-operated calcium entry

[Term]
id: GO:0106130
name: purine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate." [PMID:5123876]
xref: Reactome:R-HSA-74215 "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP"
xref: Reactome:R-HSA-9734274 "Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP"
xref: Reactome:R-HSA-9748951 "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP"
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0106134
name: positive regulation of cardiac muscle cell contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381]
is_a: GO:0086004 ! regulation of cardiac muscle cell contraction
is_a: GO:1903116 ! positive regulation of actin filament-based movement
relationship: positively_regulates GO:0086003 ! cardiac muscle cell contraction

[Term]
id: GO:0106135
name: negative regulation of cardiac muscle cell contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0055118 ! negative regulation of cardiac muscle contraction
is_a: GO:0086004 ! regulation of cardiac muscle cell contraction
relationship: negatively_regulates GO:0086003 ! cardiac muscle cell contraction

[Term]
id: GO:0106136
name: lectin-induced modified bacterial internalization
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:rjd, PMID:30049880]
synonym: "LIMBI" EXACT []
is_a: GO:0051702 ! biological process involved in interaction with symbiont

[Term]
id: GO:0106137
name: IkappaB kinase complex binding
namespace: molecular_function
def: "Binding to a IkappaB kinase complex." [GOC:pga, PMID:12492477]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0106138
name: Sec61 translocon complex binding
namespace: molecular_function
def: "Binding to a Sec61 translocon complex." [GOC:pga, PMID:9792704]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0106139
name: symbiont cell surface
namespace: cellular_component
def: "The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:rjd, PMID:30049880]
synonym: "endosymbiont cell surface" EXACT []
is_a: GO:0044217 ! other organism part

[Term]
id: GO:0106140
name: P-TEFb complex binding
namespace: molecular_function
def: "Binding to a P-TEFb complex." [GOC:pga, PMID:18391197]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0106141
name: flavin prenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2." [PMID:26083743, RHEA:37743]
xref: EC:2.5.1.129
xref: RHEA:37743
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0106142
name: rRNA (adenine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA." [EC:2.1.1.287, PMID:23180764]
comment: The m(1)A modification at position 645 in the large rRNA is highly conserved in eukaryotes.
synonym: "25S rRNA (adenine(645)-N(1))-methyltransferase" RELATED [EC:2.1.1.287]
synonym: "25S rRNA m(1)A(645) methyltransferase" RELATED [EC:2.1.1.287]
xref: EC:2.1.1.287
xref: RHEA:43792
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0106143
name: tRNA (m7G46) methyltransferase complex
namespace: cellular_component
def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat)." [GOC:vw, PMID:15811913, PMID:1738232, PMID:18164779, PMID:18184583]
synonym: "Trm8-Trm82 complex" EXACT []
synonym: "tRNA (m7G46) methyltransferase" EXACT []
synonym: "tRNA m7G methylation complex" EXACT []
is_a: GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0106144
name: fraxetin 5-hydroxylase activity
namespace: molecular_function
def: "Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20." [GOC:lr, PMID:29581584, RHEA:57844]
xref: EC:1.14.14.164
xref: RHEA:57844
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106145
name: scopoletin 8-hydroxylase activity
namespace: molecular_function
def: "Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2)." [GOC:lr, PMID:29361149, PMID:29581584, RHEA:57848]
xref: EC:1.14.11.60
xref: RHEA:57848
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106146
name: sideretin biosynthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sideretin." [GOC:lr, PMID:29581584]
is_a: GO:0009805 ! coumarin biosynthetic process

[Term]
id: GO:0106147
name: fraxetin biosynthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fraxetin." [GOC:lr, PMID:29581584]
is_a: GO:0009805 ! coumarin biosynthetic process

[Term]
id: GO:0106148
name: 4-hydroxyindole-3- carbonyl nitrile biosynthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyindole-3- carbonyl nitrile (4-OH-ICN), a cyanogenic glucoside." [GOC:lr, PMID:26352477]
is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process

[Term]
id: GO:0106149
name: indole-3-carbonyl nitrile 4-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP+ + H20." [GOC:lr, PMID:26352477, RHEA:57864]
xref: EC:1.14.14.165
xref: RHEA:57864
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106150
name: zearalenone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals." [GOC:ach, PMID:16517624, PMID:20578001]
is_a: GO:0033068 ! macrolide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0106151
name: CNBH domain intrinsic ligand binding
namespace: molecular_function
def: "Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide." [GOC:cvs, PMID:27025590, PMID:29567795]
comment: It is unclear if the motif bound by CNBHD is a specific motif or just a beta sheet with the appropriate amino acids.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0106153
name: phosphorylated histone binding
namespace: molecular_function
def: "Binding to a histone in which a residue has been modified by phosphorylation." [GOC:mah, PMID:20679485]
is_a: GO:0042393 ! histone binding
is_a: GO:0140031 ! phosphorylation-dependent protein binding

[Term]
id: GO:0106154
name: perithecium formation
namespace: biological_process
def: "The process of producing flask-shaped fruiting bodies, called perithecia. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck." [DOI:10.1007/978-3-642-00286-1_2, GOC:ach, PMID:19547974, PMID:21134480, PMID:25311923]
is_a: GO:0120165 ! perithecium development

[Term]
id: GO:0106155
name: peptidyl-lysine 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2." [GOC:al, PMID:29915238, RHEA:57152]
xref: EC:1.14.11.63
xref: Reactome:R-HSA-9629578 "JMJD7 dimer hydroxlates a lysine residue of DRG2"
xref: Reactome:R-HSA-9629591 "JMJD7 dimer hydroxlates a lysine residue of DRG1"
xref: RHEA:57152
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0106156
name: peptidyl-lysine 4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2." [GOC:pde, PMID:24486019, RHEA:57156]
xref: Reactome:R-HSA-9629946 "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1"
xref: RHEA:57156
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0106157
name: peptidyl-arginine 3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0140554
def: "Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate." [PMID:29563586]
synonym: "L-arginine 3-hydroxylase activity" EXACT []
xref: EC:1.14.11.73
xref: Reactome:R-HSA-9629869 "KDM8:Fe2+ hydroxylates an arginine residue of RPS6"
xref: Reactome:R-HSA-9629888 "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1"
xref: RHEA:56744
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0106158
name: glycero-3-phosphocholine acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine." [PMID:18430972, PMID:27758859, RHEA:58476]
synonym: "glycerophosphocholine O-acyltransferase activity" EXACT []
synonym: "GPACT activity" EXACT []
xref: RHEA:58476
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0106159
name: obsolete regulation of small RNA loading onto RISC
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent small RNA loading onto RISC." [GOC:ha, PMID:29775584]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0106160
name: obsolete negative regulation of small RNA loading onto RISC
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of small RNA loading onto RISC." [GOC:ha, PMID:29775584]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0106161
name: obsolete positive regulation of small RNA loading onto RISC
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of small RNA loading onto RISC." [GOC:ha, PMID:29775584]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0106162
name: mRNA N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H+ + phosphate." [GOC:sp, PMID:30449621]
xref: RHEA:58480
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0106163
name: obsolete regulation of exonucleolytic catabolism of deadenylated mRNA
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true
replaced_by: GO:1900151

[Term]
id: GO:0106164
name: obsolete positive regulation of exonucleolytic catabolism of deadenylated mRNA
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true
replaced_by: GO:1900153

[Term]
id: GO:0106165
name: obsolete negative regulation of exonucleolytic catabolism of deadenylated mRNA
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true
replaced_by: GO:1900152

[Term]
id: GO:0106166
name: spindle pole body-nuclear membrane anchor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body." [GOC:vw, PMID:9763447]
synonym: "nuclear membrane-spindle pole body anchor activity" EXACT []
synonym: "spindle pole body nuclear membrane anchor activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity
is_a: GO:0140475 ! spindle pole body anchor activity

[Term]
id: GO:0106167
name: extracellular ATP signaling
namespace: biological_process
def: "The series of molecular signals mediated by the detection of extracellular ATP." [GOC:tb, PMID:12948585, PMID:20817461, PMID:29274390]
is_a: GO:0007165 ! signal transduction
is_a: GO:0071318 ! cellular response to ATP

[Term]
id: GO:0106172
name: COPI-coated vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a COPI-coated endocytic vesicle." [GOC:pde, PMID:29535154]
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0106173
name: COPII-coated vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a COPII-coated endocytic vesicle." [GOC:pde, PMID:21172817]
is_a: GO:0060205 ! cytoplasmic vesicle lumen

[Term]
id: GO:0106174
name: phagolysosome vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a phagolysosome." [GOC:pde, PMID:29471269]
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0060205 ! cytoplasmic vesicle lumen
is_a: GO:0097013 ! phagocytic vesicle lumen
relationship: part_of GO:0032010 ! phagolysosome

[Term]
id: GO:0106175
name: phagolysosome vesicle membrane
namespace: cellular_component
def: "The lipid bylayer surrounding a phagolysosome." [GOC:pde, PMID:29471269]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0032010 ! phagolysosome

[Term]
id: GO:0106176
name: clathrin-coated endocytic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a clathrin-coated endocytic vesicle." [GOC:pde, PMID:2516741]
is_a: GO:0071682 ! endocytic vesicle lumen
relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle

[Term]
id: GO:0106177
name: cyclic-GMP-AMP hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP." [GOC:sp, PMID:25344812, RHEA:58808]
xref: RHEA:58808
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0106178
name: obsolete translocase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis the movement of ions or molecules across membranes or their separation within membranes." [GOC:hjd, http://www.enzyme-database.org/]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106179
name: obsolete translocase activity acting on inorganic cations and their chelates
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates." [GOC:hjd, http://www.enzyme-database.org/]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106180
name: obsolete translocase activity of hydrons
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of hydrons (hydron being the general name for H+ in its natural abundance)." [GOC:hjd, http://www.enzyme-database.org/]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106181
name: obsolete translocase activity acting on inorganic anions
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic anions." [GOC:hjd, http://www.enzyme-database.org/]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106182
name: obsolete translocase activity acting on amino acids and peptides.
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides." [GOC:hjd, http://www.enzyme-database.org/]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106183
name: obsolete translocase activity acting on carbohydrates and their derivatives.
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of carbohydrates and their derivatives." [GOC:hjd, http://www.enzyme-database.org/]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106184
name: obsolete translocation activity acting on other compounds
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of other compounds not included in EC:7.1 through EC:7.5 ." [GOC:hjd, http://www.enzyme-database.org/]
comment: This term was made obsolete because the name and scope ( other compounds not included in EC:7.1 through EC:7.5 ) is not good ontological practice.
is_obsolete: true

[Term]
id: GO:0106185
name: obsolete histone H3-K37 methylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 37 of the histone." [GOC:mah, PMID:30773398]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 K37 methylation" EXACT []
synonym: "histone H3K37me" EXACT []
synonym: "histone lysine H3 K37 methylation" EXACT []
is_obsolete: true
consider: GO:0062122

[Term]
id: GO:0106186
name: cytoplasmic side of plasma membrane, cell tip
namespace: cellular_component
def: "The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:vw, PMID:28292899]
is_a: GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0031520 ! plasma membrane of cell tip

[Term]
id: GO:0106187
name: obsolete translocase activity acting on hydrons linked to oxidoreductase reactions
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of hydrons linked to an oxidoreduction reaction." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106188
name: obsolete translocase activity acting on hydrons linked the hydrolysis of a nucleoside triphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106189
name: obsolete translocase activity acting on hydrons linked to the hydrolysis of a diphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106190
name: obsolete translocase activity acting on hydrons linked to a decarboxylation reaction
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of hydrons linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106191
name: obsolete translocase activity acting on inogranic cations linked to oxidoreductase reactions
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic cations linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106192
name: obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106193
name: obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a diphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106194
name: obsolete translocase activity acting on inorganic cations and their chelates linked to a decarboxylation reaction
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transocation of inorganic cations and their chelates linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106195
name: obsolete translocase activity acting on inorganic anions linked to oxidoreductase reactions
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic anions linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106196
name: obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a nucleoside triphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic anions linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106197
name: obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a diphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of inorganic anions llinked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106198
name: obsolete translocase activity acting on inorganic anions linked to a decarboxylation reaction
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of an inorganic anion linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106199
name: obsolete translocase activity acting on amino acids and peptides linked to oxidoreductase reactions
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106200
name: obsolete translocase activity acting on amio acids and peptides linked to the hydrolysis of a nucleoside triphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106201
name: obsolete translocase activity acting on amino acids and peptides linked to the hydrolysis of a diphosphate
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106202
name: obsolete translocase activity acting on amino acids and peptides linked to a decarboxylation reaction
namespace: molecular_function
def: "OBSOLETE. Catalysis of the translocation of amno acids and peptides linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org]
comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter branch of the onotolgy was consided confusing.
is_obsolete: true

[Term]
id: GO:0106210
name: culmorin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris." [GOC:ach, PMID:19880637, PMID:26673640]
synonym: "culmorin anabolism" EXACT []
synonym: "culmorin biosynthesis" EXACT []
synonym: "culmorin formation" EXACT []
synonym: "culmorin synthesis" EXACT []
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0106211
name: inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H+ + phosphate." [GOC:rn, PMID:29540476]
synonym: "5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate diphosphatase activity" EXACT []
synonym: "5-diphosphoinositol 1,3,4,6-tetrakisphosphate diphosphatase activity" EXACT []
synonym: "5-PP-InsP4 activity" EXACT []
xref: RHEA:59500
is_a: GO:0052840 ! inositol diphosphate tetrakisphosphate diphosphatase activity

[Term]
id: GO:0106212
name: centromere detachment from spindle pole body involved in meiotic chromosome organization
namespace: biological_process
def: "The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I." [GOC:mah, PMID:27611693]
synonym: "centromere detachment from SPB involved in meiotic chromosome organization" EXACT []
synonym: "centromere detachment from spindle pole body involved in chromosome organization involved in meiotic cell cycle" EXACT []
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle

[Term]
id: GO:0106213
name: kinetochore disassembly involved in meiotic chromosome organization
namespace: biological_process
def: "The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I." [GOC:mah, PMID:27611693]
synonym: "kinetochore disassembly from spindle pole body involved in chromosome organization involved in meiotic cell cycle" EXACT []
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle

[Term]
id: GO:0106214
name: regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:1903358 ! regulation of Golgi organization
relationship: regulates GO:0048280 ! vesicle fusion with Golgi apparatus

[Term]
id: GO:0106215
name: negative regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus
relationship: negatively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus

[Term]
id: GO:0106216
name: positive regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus
relationship: positively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus

[Term]
id: GO:0106217
name: tRNA C3-cytosine methylation
namespace: biological_process
def: "The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine." [PMID:28655767]
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0106218
name: galactosaminogalactan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactosaminogalactan. GAG is a heteropolysaccharide composed of alpha-1,4 linked galactose, N-acetyl galactosamine (GalNAc) and galactosamine (GalN)." [PMID:173713, PMID:22102815, PMID:24257745, PMID:26492565, PMID:26932183, PMID:27048799, PMID:30667338]
synonym: "GAG biosynthetic process" RELATED []
synonym: "galactosaminogalactan anabolism" RELATED []
synonym: "galactosaminogalactan biosynthesis" RELATED []
synonym: "galactosaminogalactan formation" RELATED []
synonym: "galactosaminogalactan synthesis" RELATED []
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process

[Term]
id: GO:0106219
name: zinc ion sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc." [GOC:vw, PMID:31239353]
is_a: GO:0140784 ! metal ion sensor activity

[Term]
id: GO:0106220
name: pyocyanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group." [PMID:28715477]
synonym: "pyocyanin biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0106222
name: lncRNA binding
namespace: molecular_function
def: "Binding to a long noncoding RNA (lncRNA)." [PMID:25578728]
synonym: "long noncoding RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0106223
name: germacrene A hydroxylase activity
namespace: molecular_function
alt_id: GO:0102260
def: "Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]." [PMID:11299372, PMID:20351109, RHEA:30303]
synonym: "germacrene A alcohol dehydrogenase activity" RELATED []
xref: EC:1.14.14.95
xref: MetaCyc:RXN-19749
xref: RHEA:30303
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106225
name: obsolete peptidyl-lysine 2-hydroxyisobutyrylation
namespace: biological_process
def: "OBSOLETE. The 2-hydroxyisobutyrylation of a lysine residue in a protein." [GOC:sp, PMID:29775581]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0106226
name: peptide 2-hydroxyisobutyryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide." [GOC:sp, PMID:29775581]
xref: RHEA:24180
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0106227
name: peptidyl-lysine glutarylation
namespace: biological_process
def: "The glutarylation of a lysine residue in a protein." [GOC:sp, PMID:31542297]
subset: gocheck_obsoletion_candidate
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0106228
name: peptide glutaryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]." [GOC:sp, PMID:31542297]
xref: RHEA:18009
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0106229
name: histone glutaryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone." [GOC:sp, PMID:31542297]
is_a: GO:0106228 ! peptide glutaryltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0106230
name: protein depropionylation
namespace: biological_process
def: "The removal of a propionyl group from a residue in a peptide or protein." [GOC:sp, PMID:30026585]
subset: gocheck_obsoletion_candidate
is_a: GO:0035601 ! protein deacylation

[Term]
id: GO:0106231
name: NAD-dependent protein-lysine depropionylase activity
namespace: molecular_function
def: "Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:sp, PMID:30026585, RHEA:23500]
comment: This reaction is the removal of a propionyl group from a propionylated lysine residue of a protein or peptide.
xref: RHEA:23500
is_a: GO:0141218 ! NAD-dependent protein lysine deacylase activity

[Term]
id: GO:0106232
name: hydroxyisourate hydrolase complex
namespace: cellular_component
def: "A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin." [GOC:bhm, PMID:21795808]
synonym: "5-hydroxyisourate hydrolase complex" NARROW []
synonym: "HIU hydrolase complex" NARROW []
synonym: "HIUH complex" NARROW []
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0106233
name: glycosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a glycosome, a membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:ach, PMID:15539076, PMID:28426655, PMID:31341002, PMID:8056787]
synonym: "glycosome biogenesis" RELATED []
synonym: "glycosome organisation" EXACT []
synonym: "glycosome organization and biogenesis" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0106234
name: outer membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC." [GOC:am, PMID:25267629, PMID:27282389]
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0106235
name: ceramide-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate." [GOC:lb, PMID:10359651]
xref: RHEA:50888
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0106236
name: rhamnolipid biosynthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation/production of a glycolipid surfactant that acts as a bacterial biofilm dispersal." [GOC:vw, PMID:28715477]
synonym: "rhamnolipid production" RELATED []
is_a: GO:0009247 ! glycolipid biosynthetic process

[Term]
id: GO:0106237
name: arachidonate 12(R)-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [GOC:gap, PMID:10100631, PMID:11256953, RHEA:41336]
xref: RHEA:41336
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0106238
name: peregrinol diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O." [GOC:emb, PMID:24990389, PMID:29315936, RHEA:54652]
xref: EC:4.2.1.174
xref: RHEA:54652
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0106239
name: 9,13-epoxylabda-14-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate." [GOC:emb, PMID:24990389, RHEA:54512]
xref: EC:4.2.3.189
xref: RHEA:54512
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0106240
name: labd-13Z-ene-9,15,16-triol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H+ + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]." [GOC:eab, PMID:29315936, RHEA:62192]
xref: RHEA:62192
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0106242
name: kolavenyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate." [GOC:eab, PMID:29315936, RHEA:54676]
xref: EC:5.5.1.29
xref: RHEA:54676
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0106243
name: syn-isopimara-7,15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene." [GOC:emb, PMID:29315936, RHEA:62188]
xref: RHEA:62188
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0106244
name: eupatolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:eab, PMID:29758164, RHEA:57972]
xref: EC:1.14.14.169
xref: RHEA:57972
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0106245
name: L-serine-phosphatidylethanolamine phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606]
xref: EC:2.7.8.29
xref: RHEA:27606
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0106246
name: regulation of poly(A)-specific ribonuclease activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [GOC:mah, PMID:29932902]
subset: gocheck_obsoletion_candidate
is_a: GO:1901917 ! regulation of exoribonuclease activity

[Term]
id: GO:0106247
name: obsolete negative regulation of poly(A)-specific ribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of poly(A)-specific ribonuclease activity." [GOC:mah, PMID:29932902]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0106248
name: obsolete positive regulation of poly(A)-specific ribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of poly(A)-specific ribonuclease activity." [GOC:mah, PMID:29932902]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0106249
name: Nicalin-NOMO complex
namespace: cellular_component
def: "A protein complex regulating Nodal signaling. Subunits are highly conserved in vertebrates and include Nicalin, NOMO and TMEM147." [GOC:al, GOC:bhm, PMID:20538592]
synonym: "Nicalin-TMEM147-NOMO complex" EXACT [PMID:32820719]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0106250
name: DNA-binding transcription repressor activity, RNA polymerase III-specific
namespace: molecular_function
def: "A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III." [GOC:txnOH-2018, PMID:15590667, PMID:31833215]
comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
is_a: GO:0001217 ! DNA-binding transcription repressor activity

[Term]
id: GO:0106251
name: N4-acetylcytidine amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate." [GOC:imk, PMID:31964920, RHEA:62932]
xref: RHEA:62932
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0106253
name: positive regulation of DNA strand resection involved in replication fork processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:vw, PMID:31575705]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0110026 ! regulation of DNA strand resection involved in replication fork processing
relationship: positively_regulates GO:0110025 ! DNA strand resection involved in replication fork processing

[Term]
id: GO:0106254
name: lipid sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid." [GOC:vw, PMID:30075144]
synonym: "lipid sensing activity" EXACT []
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0106255
name: hydroperoxy icosatetraenoate isomerase activity
namespace: molecular_function
def: "A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate." [PMID:12881489, RHEA:55560]
xref: EC:5.4.4.7
xref: RHEA:55560
is_a: GO:0050486 ! intramolecular hydroxytransferase activity

[Term]
id: GO:0106256
name: hydroperoxy icosatetraenoate dehydratase activity
namespace: molecular_function
def: "A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O." [PMID:12881489, RHEA:55556]
xref: EC:4.2.1.152
xref: RHEA:55556
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0106258
name: L-serine-phosphatidylcholine phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline." [PMID:19014349, RHEA:45088]
xref: RHEA:45088
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0106259
name: symbiont-mediated cell-to-cell migration in host
namespace: biological_process
def: "The directional movement of a symbiont from one host cell to another." [GOC:vw, PMID:18456802, PMID:19262673, PMID:19816653, PMID:29567712]
synonym: "cell-to-cell migration in host" EXACT []
synonym: "symbiont-mediated dissemination across host cells" EXACT []
is_a: GO:0044001 ! migration in host

[Term]
id: GO:0106260
name: DNA-DNA tethering activity
namespace: molecular_function
alt_id: GO:0140564
def: "Bridging together two regions of a DNA molecule." [PMID:29358048, PMID:30626735]
synonym: "double-stranded DNA bridging" EXACT []
synonym: "dsDNA bridging" EXACT []
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0106261
name: tRNA uridine(34) acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H+ + L-methionine." [PMID:25151136, PMID:30733442, RHEA:61020]
xref: EC:2.3.1.311
xref: RHEA:61020
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0106262
name: 1-acylglycerophosphoethanolamine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA." [PMID:18287005, RHEA:32995]
xref: EC:2.3.1.n7
xref: RHEA:32995
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0106263
name: 1-acylglycerophosphoserine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA." [PMID:18287005, RHEA:33191]
xref: EC:2.3.1.n6
xref: RHEA:33191
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0106264
name: protein serine kinase activity (using GTP as donor)
namespace: molecular_function
def: "Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein]." [GOC:sp, PMID:32322062, RHEA:64020]
xref: RHEA:64020
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0106265
name: THPH synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA." [PMID:9446571, RHEA:64352]
synonym: "polyketide syntase" BROAD []
xref: RHEA:64352
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0106266
name: 3-chloro THPH synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O." [PMID:20231486, RHEA:64356]
xref: RHEA:64356
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106267
name: 3,5 dichloro-THPH synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O." [PMID:20231486, RHEA:64360]
xref: RHEA:64360
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106268
name: 3,5-dichloro-THPH methyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine." [PMID:20231486, RHEA:48396]
synonym: "DIF-1 syntase" RELATED []
xref: RHEA:48396
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0106271
name: D-arabinose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH." [RHEA:21892]
xref: RHEA:21892
is_a: GO:0045290 ! D-arabinose 1-dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0106272
name: protein localization to ERGIC
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059]
is_a: GO:0034067 ! protein localization to Golgi apparatus

[Term]
id: GO:0106273
name: cytosol to ERGIC protein transport
namespace: biological_process
def: "The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059]
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0106274
name: NAD+-protein-arginine ADP-ribosyltransferase activity
namespace: molecular_function
alt_id: GO:0003956
alt_id: GO:0106275
def: "Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide." [RHEA:19149]
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31]
synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31]
synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)+-protein-arginine ADP-ribosyltransferase activity" BROAD []
synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" RELATED [EC:2.4.2.31]
synonym: "NADP+-protein-arginine ADP-ribosyltransferase activity" BROAD []
synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT []
synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.31
xref: MetaCyc:2.4.2.31-RXN
xref: Reactome:R-HSA-1972385 "ADP-Ribosylation of HNP-1"
xref: RHEA:19149
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0106276
name: biliberdin reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: bilirubin IXalpha + NAD+ = biliverdin IXalpha + NADH+ H+." [RHEA:15797]
xref: RHEA:15797
is_a: GO:0004074 ! biliverdin reductase [NAD(P)+] activity

[Term]
id: GO:0106277
name: biliverdin reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: bilirubin IXalpha + NADP+ = biliverdin IXalpha + NADPH + H+." [RHEA:15793]
xref: RHEA:15793
is_a: GO:0004074 ! biliverdin reductase [NAD(P)+] activity

[Term]
id: GO:0106278
name: regulation of UDP-N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the UDP-N_acetylglucosamine biosynthetic process." [PMID:32579556]
synonym: "regulation of UDP-GlcNAc biosynthetic process" RELATED []
synonym: "regulation of UDP-N-acetylglucosamine anabolism" RELATED []
synonym: "regulation of UDP-N-acetylglucosamine biosynthesis" RELATED []
synonym: "regulation of UDP-N-acetylglucosamine formation" RELATED []
synonym: "regulation of UDP-N-acetylglucosamine synthesis" RELATED []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process

[Term]
id: GO:0106279
name: negative regulation of UDP-N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556]
synonym: "negative regulation of UDP-GlcNAc biosynthesis" RELATED []
synonym: "negative regulation of UDP-GlcNAc biosynthetic process" RELATED []
synonym: "negative regulation of UDP-N-acetylglucosamine anabolism" RELATED []
synonym: "negative regulation of UDP-N-acetylglucosamine biosynthesis" RELATED []
synonym: "negative regulation of UDP-N-acetylglucosamine formation" RELATED []
synonym: "negative regulation of UDP-N-acetylglucosamine synthesis" RELATED []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process
relationship: negatively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process

[Term]
id: GO:0106280
name: positive regulation of UDP-N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556]
synonym: "positive egulation of UDP-N-acetylglucosamine formation" RELATED []
synonym: "positive regulation of UDP-GlcNAc biosynthetic process" RELATED []
synonym: "positive regulation of UDP-N-acetylglucosamine anabolism" RELATED []
synonym: "positive regulation of UDP-N-acetylglucosamine biosynthesis" RELATED []
synonym: "positive regulation of UDP-N-acetylglucosamine synthesis" RELATED []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process
relationship: positively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process

[Term]
id: GO:0106281
name: chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: chenodeoxycholate + NAD+ = 7-oxolithocholate + H+ + NADH." [PMID:12917011, RHEA:42036]
xref: RHEA:42036
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0106282
name: isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta,7-beta-dihydroxy-5-beta-cholan-24-oate + NAD+ = 3-beta-hydroxy-7-oxo-5-beta-cholan-24-oate + H+ + NADH." [PMID:12917011, RHEA:42024]
xref: RHEA:42024
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0106283
name: ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + ursodeoxycholate = 7-oxolithocholate + H+ + NADH." [PMID:12917011, RHEA:42028]
xref: RHEA:42028
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0106286
name: (E)-caffeate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate." [PMID:22649270, RHEA:36299]
xref: RHEA:36299
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0106288
name: regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA." [PMID:32354837]
is_a: GO:0061013 ! regulation of mRNA catabolic process
relationship: regulates GO:0000290 ! deadenylation-dependent decapping of nuclear-transcribed mRNA

[Term]
id: GO:0106289
name: negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA." [PMID:32354837]
is_a: GO:0106288 ! regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA
is_a: GO:1902373 ! negative regulation of mRNA catabolic process
relationship: negatively_regulates GO:0000290 ! deadenylation-dependent decapping of nuclear-transcribed mRNA

[Term]
id: GO:0106290
name: trans-cinnamate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate." [PMID:22649270, RHEA:64788]
xref: RHEA:64788
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0106291
name: superoxide-generating NADH oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + 2 O2 = H+ + NAD+ + 2 superoxide." [RHEA:63184]
xref: RHEA:63184
is_a: GO:0016175 ! superoxide-generating NAD(P)H oxidase activity

[Term]
id: GO:0106292
name: superoxide-generating NADPH oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + 2 O2 = H+ + NADP+ + 2 superoxide." [RHEA:63180]
xref: RHEA:63180
is_a: GO:0016175 ! superoxide-generating NAD(P)H oxidase activity

[Term]
id: GO:0106293
name: NADH oxidase H202-forming activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2)." [RHEA:11264]
xref: RHEA:11264
is_a: GO:0016174 ! NAD(P)H oxidase H2O2-forming activity

[Term]
id: GO:0106294
name: NADPH oxidase H202-forming activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2)." [RHEA:11260]
xref: RHEA:11260
is_a: GO:0016174 ! NAD(P)H oxidase H2O2-forming activity

[Term]
id: GO:0106295
name: resolvin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of resolvins, di- or trihydroxy fatty acids derived from omega-3 polyunsaturated fatty acids, specifically icosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid." [PMID:24899309]
comment: Resolvin biosynthesis is a combination of oxidation, reduction and hydrolysis reactions involving lipoxygenases and cyclooxygenases.
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0106296
name: D-series resolvin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of resolvin family D-series, hydroxy fatty acids derived from docosahexaenoic acid." [PMID:12391014]
is_a: GO:0106295 ! resolvin biosynthetic process

[Term]
id: GO:0106297
name: E-series resolvin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of resolvin family E-series, hydroxy fatty acids derived from icosapentaenoic acid." [PMID:21206090]
is_a: GO:0106295 ! resolvin biosynthetic process

[Term]
id: GO:0106298
name: 13-series resolvin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of resolvin family 13-series, hydroxy fatty acids derived from docosapentaenoic acid." [PMID:26236990]
is_a: GO:0106295 ! resolvin biosynthetic process

[Term]
id: GO:0106299
name: resolution phase response
namespace: biological_process
def: "An active host response phase of acute inflammation driven by specialized pro-resolving mediators (SPMs) and signaling pathways, enabling timely tissue regeneration and return of function." [PMID:28087575]
comment: Acute inflammatory response(s) are self-limited, resolve on their own and classically divide into initiation and resolution phases. SPMs are a superfamily of proresolving mediators that include resolvins (Rvs), protectins (PDs), maresins (MaRs) and lipoxins (LXs).
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0106300
name: protein-DNA covalent cross-linking repair
namespace: biological_process
def: "The removal of covalent cross-link between DNA and a protein." [PMID:31921408]
synonym: "resolution of protein-DNA covalent cross-linking" EXACT []
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0106301
name: arachidonate 5,6-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid." [PMID:10491410, PMID:8631948, RHEA:49936]
synonym: "arachidonic acid 5,6-epoxygenase activity" EXACT []
xref: RHEA:49936
is_a: GO:0008392 ! arachidonate epoxygenase activity

[Term]
id: GO:0106302
name: arachidonate 8,9-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid." [PMID:10491410, PMID:8246128, RHEA:64984]
synonym: "arachidonic acid 8,9-epoxygenase activity" EXACT []
xref: RHEA:64984
is_a: GO:0008392 ! arachidonate epoxygenase activity

[Term]
id: GO:0106303
name: mannogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania." [PMID:12902334, PMID:16766650, PMID:31513773, PMID:31662278]
synonym: "beta-1,2-mannan metabolic process" RELATED []
synonym: "mannogen metabolism" RELATED []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0106304
name: mannogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania." [PMID:16766650, PMID:31513773, PMID:31662278]
synonym: "beta-1,2-mannan biosynthetic process" RELATED []
synonym: "mannogen anabolism" RELATED []
synonym: "mannogen biosynthesis" RELATED []
synonym: "mannogen formation" RELATED []
synonym: "mannogen synthesis" RELATED []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0106303 ! mannogen metabolic process

[Term]
id: GO:0106305
name: mannogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania." [PMID:12902334, PMID:31513773, PMID:31662278]
synonym: "beta-1,2-mannan catabolic process" RELATED []
synonym: "beta-1,2-mannan catabolism" RELATED []
synonym: "mannogen breakdown" RELATED []
synonym: "mannogen catabolism" RELATED []
synonym: "mannogen degradation" RELATED []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0106303 ! mannogen metabolic process

[Term]
id: GO:0106309
name: progesterone 21-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:25855791, RHEA:50304]
xref: Reactome:R-HSA-193964 "CYP21A2 21-hydroxylates PROG"
xref: Reactome:R-HSA-193981 "CYP21A2 oxidises 17HPROG"
xref: RHEA:50304
is_a: GO:0004509 ! steroid 21-monooxygenase activity

[Term]
id: GO:0106310
name: protein serine kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989]
comment: Note that this term is to annotate proteins the specifically phosphorylate a serine residue on a protein. An example is human PIKFYVE (UniProt:Q9Y2I7). For dual specificity protein kinases, use 'protein serine/threonine kinase activity' ; GO:0004712.
synonym: "protein-serine kinase activity" EXACT []
xref: Reactome:R-HSA-9729330 "SRPK1/2 phosphorylates nucleoprotein"
xref: Reactome:R-HSA-9821967 "SRPK1 phosphorylates PRM2 in PRM2:dsDNA"
xref: Reactome:R-HSA-9821982 "SRPK1 phosphorylates PRM1 in PRM1:dsDNA"
xref: Reactome:R-HSA-9841265 "p-S473-AKT1 phosphorylates ESR1 on serine-167"
xref: Reactome:R-HSA-9860792 "Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177"
xref: Reactome:R-HSA-9860808 "p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179"
xref: RHEA:17989
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0106312
name: methylenetetrahydrofolate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H+." [RHEA:19821]
xref: EC:1.5.1.54
xref: MetaCyc:RXN-22438
xref: RHEA:19821
is_a: GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity

[Term]
id: GO:0106313
name: methylenetetrahydrofolate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H+." [RHEA:19817]
xref: EC:1.5.1.53
xref: MetaCyc:RXN-21991
xref: RHEA:19817
is_a: GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity

[Term]
id: GO:0106314
name: obsolete nitrite reductase NADPH activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ammonium hydroxide + 3 NADP+ + H2O = nitrite + 3 NADPH + 3 H+." [GOC:curators]
comment: This term was obsoleted because it is believed to be a spontaneous reaction.
is_obsolete: true
replaced_by: GO:0008942

[Term]
id: GO:0106316
name: nitrite reductase NADH activity
namespace: molecular_function
def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+." [RHEA:24628]
xref: EC:1.7.1.15
xref: RHEA:24628
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0106317
name: obsolete methane monooxygenase NADH activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O." [RHEA:13637]
comment: This term was obsoleted because it represents the same activity as methane monooxygenase [NAD(P)H] activity ; GO:0015049.
is_obsolete: true
replaced_by: GO:0015049

[Term]
id: GO:0106318
name: obsolete methane monooxygenase NADPH activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O." [RHEA:13641]
comment: This term was obsoleted because it represents the same activity as methane monooxygenase [NAD(P)H] activity ; GO:0015049.
is_obsolete: true
replaced_by: GO:0015049

[Term]
id: GO:0106319
name: obsolete (R)-limonene 1,2-monooxygenase NADH activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide." [RHEA:26093]
comment: This term was obsoleted because it represents a specific substrate of limonene 1,2-monooxygenase activity ; GO:0052601.
is_obsolete: true
replaced_by: GO:0052601

[Term]
id: GO:0106320
name: obsolete (R)-limonene 1,2-monooxygenase NADPH activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide." [RHEA:26097]
comment: This term was obsoleted because it represents a specific substrate of limonene 1,2-monooxygenase activity ; GO:0052601.
is_obsolete: true
replaced_by: GO:0052601

[Term]
id: GO:0106321
name: S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+." [RHEA:19981]
xref: RHEA:19981
is_a: GO:0051903 ! S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0106322
name: S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+." [RHEA:19985]
xref: RHEA:19985
is_a: GO:0051903 ! S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0106323
name: obsolete (S)-limonene 1,2-monooxygenase NADPH activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide." [RHEA:26085]
comment: This term was obsoleted because it represents a specific substrate of limonene 1,2-monooxygenase activity ; GO:0052601.
is_obsolete: true
replaced_by: GO:0052601

[Term]
id: GO:0106324
name: obsolete (S)-limonene 1,2-monooxygenase NADH activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide." [RHEA:26089]
comment: This term was obsoleted because it represents a specific substrate of limonene 1,2-monooxygenase activity ; GO:0052601.
is_obsolete: true
replaced_by: GO:0052601

[Term]
id: GO:0106325
name: obsolete acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP." [GOC:curators]
comment: This term was obsoleted because it is more specific than the activity of any known enzyme. The activity corresponds to acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity ; GO:0047225.
is_obsolete: true
replaced_by: GO:0047225

[Term]
id: GO:0106326
name: obsolete acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP." [GOC:curators]
comment: This term was obsoleted because it is more specific than the activity of any known enzyme. The activity corresponds to acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity ; GO:0047225.
is_obsolete: true
replaced_by: GO:0047225

[Term]
id: GO:0106327
name: obsolete acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP." [RHEA:46880]
comment: This term was obsoleted because it represents a specific substrate of acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase \nactivity; GO:0047224.
is_obsolete: true
replaced_by: GO:0047224

[Term]
id: GO:0106328
name: obsolete acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP." [RHEA:46884]
comment: This term was obsoleted because it represents a specific substrate of acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase \nactivity; GO:0047224.
is_obsolete: true
replaced_by: GO:0047224

[Term]
id: GO:0106329
name: L-phenylalaine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)." [RHEA:61240]
xref: RHEA:61240
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0106330
name: sialate 9-O-acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate." [PMID:22291594, RHEA:22600]
xref: MetaCyc:RXN-13182
xref: RHEA:22600
is_a: GO:0001681 ! sialate O-acetylesterase activity

[Term]
id: GO:0106331
name: sialate 4-O-acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate." [PMID:22291594, RHEA:25564]
xref: MetaCyc:RXN-13181
xref: RHEA:25564
is_a: GO:0001681 ! sialate O-acetylesterase activity

[Term]
id: GO:0106332
name: ds/ssDNA junction-specific dsDNA endonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction." [PMID:14528010]
is_a: GO:1990238 ! double-stranded DNA endonuclease activity

[Term]
id: GO:0106333
name: subcortical maternal complex
namespace: cellular_component
def: "Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex." [PMID:18804437, PMID:28992324]
synonym: "SCMC" RELATED []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0106334
name: 3'-deoxyribose phosphate lyase activity
namespace: molecular_function
def: "Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate." [GOC:mah, PMID:21276450, PMID:22084197, PMID:22375014, RHEA:65764]
synonym: "3'-dRP lyase" RELATED []
synonym: "3'-dRP lyase activity" RELATED []
xref: RHEA:65764
is_a: GO:0016829 ! lyase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0106335
name: tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]
xref: EC:2.1.1.229
xref: RHEA:43208
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity

[Term]
id: GO:0106336
name: yolk syncytial layer development
namespace: biological_process
def: "The progression of the yolk syncytial layer over time, from its initial formation to the mature structure. The yolk syncytial layer is the peripheral layer of the yolk cell including nuclei and non-yolky cytoplasm." [PMID:29180571]
comment: The "yolk syncytial layer" structure can be found in Teleostei, Myxini, Chondrichthyes, Lepisosteiformes and Cephalopoda according.
synonym: "YSL development" RELATED []
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0106339
name: obsolete tRNA (cytidine(32)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H+ + S-adenosyl-L-homocysteine." [PMID:25404562]
comment: The reason for obsoletion is that this term is equivalent to tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity.
synonym: "tRNA (cytidine 32-2'-O)-methyltransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0106340

[Term]
id: GO:0106340
name: tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H+ + 2 S-adenosyl-L-homocysteine." [RHEA:42396]
synonym: "tRNA (cytidine 32-2'-O)-methyltransferase activity" NARROW []
synonym: "tRNA (cytidine(32)-2'-O)-methyltransferase activity" NARROW []
synonym: "tRNA (guanosine 34-2'-O)-methyltransferase activity" NARROW []
synonym: "tRNA (guanosine(34)-2'-O)-methyltransferase activity" NARROW []
xref: EC:2.1.1.205
xref: Reactome:R-HSA-9024161 "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)"
xref: RHEA:42396
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity
is_a: GO:0016427 ! tRNA (cytidine) methyltransferase activity

[Term]
id: GO:0106341
name: omega-hydroxyceramide transacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine." [PMID:28248318, RHEA:55264]
xref: RHEA:55264
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0106342
name: omega-hydroxyceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of omega-hydroxyceramide/acylceramide." [PMID:28248318]
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0106343
name: glutarate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2." [PMID:30498244, RHEA:13821]
xref: EC:1.14.11.64
xref: RHEA:13821
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity

[Term]
id: GO:0106344
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]." [PMID:22568620, RHEA:65756]
xref: RHEA:65756
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0106345
name: glyoxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H." [GOC:curators, PMID:3548703]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0106346
name: snRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule." [PMID:27573892]
is_a: GO:0008173 ! RNA methyltransferase activity

[Term]
id: GO:0106347
name: U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+." [PMID:31913360, RHEA:62672]
xref: RHEA:62672
is_a: GO:0106346 ! snRNA methyltransferase activity

[Term]
id: GO:0106348
name: U2 snRNA adenosine m6 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+." [PMID:32637152]
is_a: GO:0106346 ! snRNA methyltransferase activity

[Term]
id: GO:0106349
name: snRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in an snRNA molecule." [PMID:21823225]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0040031 ! snRNA modification

[Term]
id: GO:0106350
name: all-trans-octaprenyl-diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate." [PMID:3519603, PMID:8037730, RHEA:27798]
synonym: "octaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.90]
synonym: "terpenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.90]
synonym: "trans-heptaprenyltranstransferase activity" EXACT [EC:2.5.1.90]
synonym: "trans-prenyltransferase activity" BROAD [EC:2.5.1.90]
xref: EC:2.5.1.90
xref: RHEA:27798
is_a: GO:0120531 ! prenyl diphosphate synthase activity

[Term]
id: GO:0106354
name: tRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant tRNAs." [GOC:mah, PMID:32841241]
is_a: GO:0016078 ! tRNA decay
is_a: GO:0071025 ! RNA surveillance

[Term]
id: GO:0106355
name: 4-hydroxybenzoate 3-monooxygenase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+." [RHEA:19473]
xref: RHEA:19473
is_a: GO:0018671 ! 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity

[Term]
id: GO:0106356
name: 4-hydroxybenzoate 3-monooxygenase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+." [RHEA:19477]
synonym: "4-hydroxybenzoate 3-monooxygenase [NADPH] activity" EXACT []
xref: RHEA:19477
is_a: GO:0018671 ! 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity

[Term]
id: GO:0106357
name: glycerol-1-phosphate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH." [RHEA:21412]
synonym: "glycerol-1-phosphate dehydrogenase [NAD+] activity" EXACT []
xref: RHEA:21412
is_a: GO:0050492 ! glycerol-1-phosphate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0106358
name: glycerol-1-phosphate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH." [RHEA:21416]
synonym: "glycerol-1-phosphate dehydrogenase [NADP+] activity" EXACT []
xref: RHEA:21416
is_a: GO:0050492 ! glycerol-1-phosphate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0106359
name: 2-hydroxyacyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA." [PMID:21708296, PMID:28289220]
xref: EC:4.1.2.63
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0106360
name: obsolete 2-hydroxy-3-methylhexadecanoyl-CoA lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA." [RHEA:25379]
comment: This term was obsoleted because it represents the same activity as 2-hydroxyacyl-CoA lyase activity , GO:0106359.
is_obsolete: true
replaced_by: GO:0106359

[Term]
id: GO:0106361
name: protein-arginine rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]." [GOC:sp, PMID:25686373, PMID:26060278, RHEA:66692]
xref: RHEA:66692
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0106362
name: protein-arginine N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP." [GOC:sp, PMID:23955153, PMID:30619781, RHEA:66632]
xref: RHEA:66632
is_a: GO:0016262 ! protein N-acetylglucosaminyltransferase activity

[Term]
id: GO:0106363
name: protein-cysteine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]." [GOC:sp, PMID:21481189, PMID:22158122, PMID:24235145, PMID:25412445, RHEA:66544]
synonym: "protein cysteine methylase activity" EXACT []
synonym: "protein cysteine methyltransferase activity" EXACT []
xref: RHEA:66544
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0106364
name: 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity
namespace: molecular_function
def: "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [PMID:21944752, RHEA:20361]
xref: MetaCyc:RXN3O-58
xref: RHEA:20361
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106365
name: beta-carotene isomerase activity
namespace: molecular_function
def: "Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene." [PMID:19470589, PMID:22422982, RHEA:34455]
xref: EC:5.2.1.14
xref: RHEA:34455
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0106366
name: guanosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + guanosine = ADP + GMP." [PMID:10879466, PMID:7665468, RHEA:27710]
xref: RHEA:27710
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0106367
name: (deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP." [PMID:20497505, RHEA:62128]
xref: RHEA:62128
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0106368
name: (deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP." [PMID:20497505, RHEA:62132]
xref: RHEA:62132
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0106369
name: (deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor
namespace: molecular_function
def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP." [PMID:20497505, RHEA:62124]
xref: RHEA:62124
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0106370
name: protein-L-histidine N-pros-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine." [PMID:33563959, RHEA:67076]
xref: RHEA:67076
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0106371
name: fluorescent chlorophyll catabolite monooxygenase (deformylase) activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite." [PMID:23723324, RHEA:67172]
xref: RHEA:67172
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0106372
name: primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC." [PMID:23723324, RHEA:67176]
xref: RHEA:67176
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0106373
name: 3-deoxyglucosone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH." [PMID:17175089, RHEA:67244]
xref: RHEA:67244
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity

[Term]
id: GO:0106375
name: deoxynucleoside triphosphate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate." [RHEA:46148]
xref: RHEA:46148
is_a: GO:0016793 ! triphosphoric monoester hydrolase activity

[Term]
id: GO:0106376
name: 2-hydroxyphytanoyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA." [PMID:10468558, RHEA:25355]
xref: RHEA:25355
is_a: GO:0106359 ! 2-hydroxyacyl-CoA lyase activity

[Term]
id: GO:0106377
name: 2-hydroxy-ATP hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate." [PMID:11139615, RHEA:67392]
xref: Reactome:R-HSA-2395872 "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP"
xref: RHEA:67392
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0106378
name: 2-hydroxy-dATP hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate." [PMID:11139615, RHEA:31583]
xref: Reactome:R-HSA-2395818 "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP"
xref: RHEA:31583
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0106379
name: 8-oxo-(d)RTP hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+." [PMID:11139615]
xref: Reactome:R-HSA-9731228 "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP"
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity

[Term]
id: GO:0106380
name: purine ribonucleotide salvage
namespace: biological_process
def: "Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis." [PMID:8864750]
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0106381
name: purine deoxyribonucleotide salvage
namespace: biological_process
def: "Any process which produces a purine deoxyribonucleotide from derivatives of it, without de novo synthesis." [PMID:6605343]
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0106383
name: dAMP salvage
namespace: biological_process
def: "Any process which produces a dAMP from derivatives of it, without de novo synthesis." [PMID:21829339, PMID:6605343]
is_a: GO:0006170 ! dAMP biosynthetic process
is_a: GO:0106381 ! purine deoxyribonucleotide salvage

[Term]
id: GO:0106384
name: dGMP salvage
namespace: biological_process
def: "Any process which produces a dGMP from derivatives of it, without de novo synthesis." [PMID:21829339, PMID:6605343]
is_a: GO:0006181 ! dGMP biosynthetic process
is_a: GO:0106381 ! purine deoxyribonucleotide salvage

[Term]
id: GO:0106385
name: dIMP salvage
namespace: biological_process
def: "Any process which produces a dIMP from derivatives of it, without de novo synthesis." [PMID:8692979]
is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0106381 ! purine deoxyribonucleotide salvage

[Term]
id: GO:0106386
name: (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH." [PMID:19571038, PMID:25203508]
synonym: "(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity" EXACT []
xref: EC:1.1.1.n12
xref: RHEA:32711
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0106387
name: 'de novo' GMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanosine 5'-monophosphate (GMP) through an inosine 5'-monophosphate (IMP) intermediate." [PMID:25605736]
synonym: "'de novo' guanosine 5'-monophosphate biosynthetic process" EXACT []
is_a: GO:0006177 ! GMP biosynthetic process

[Term]
id: GO:0106388
name: 18S rRNA aminocarboxypropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine." [PMID:27084949]
xref: RHEA:63296
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140102 ! catalytic activity, acting on a rRNA

[Term]
id: GO:0106389
name: ecdysteroid 22-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+." [PMID:16899460, RHEA:67972]
synonym: "EcKinase" RELATED []
xref: MetaCyc:RXN-14755
xref: RHEA:67972
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0106391
name: bI4 intron splicing complex
namespace: cellular_component
def: "A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing." [GOC:lnp, PMID:19622748]
xref: Intact:EBI-16420264
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0106392
name: bI3 intron splicing complex
namespace: cellular_component
def: "Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing." [GOC:lnp, PMID:11773622]
xref: Intact:EBI-16426213
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0106393
name: regulation of palmitic acid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a palmitic acid catabolic process." [PMID:14677856]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:1900534 ! palmitic acid catabolic process

[Term]
id: GO:0106394
name: negative regulation of palmitic acid catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a palmitic acid catabolic process." [PMID:14677856]
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0106393 ! regulation of palmitic acid catabolic process
relationship: negatively_regulates GO:1900534 ! palmitic acid catabolic process

[Term]
id: GO:0106395
name: positive regulation of palmitic acid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a palmitic acid catabolic process." [PMID:14677856]
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0106393 ! regulation of palmitic acid catabolic process
relationship: positively_regulates GO:1900534 ! palmitic acid catabolic process

[Term]
id: GO:0106396
name: regulation of R7 cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of R7 cell fate commitment." [GOC:ha, PMID:22878552]
is_a: GO:0010453 ! regulation of cell fate commitment
relationship: regulates GO:0007465 ! R7 cell fate commitment

[Term]
id: GO:0106397
name: positive regulation of R7 cell fate commitment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of R7 cell fate commitment." [GOC:ha, PMID:22878552]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0106396 ! regulation of R7 cell fate commitment
relationship: positively_regulates GO:0007465 ! R7 cell fate commitment

[Term]
id: GO:0106398
name: negative regulation of R7 cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of R7 cell fate commitment." [GOC:ha, PMID:22878552]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0106396 ! regulation of R7 cell fate commitment
relationship: negatively_regulates GO:0007465 ! R7 cell fate commitment

[Term]
id: GO:0106399
name: obsolete acyl-coenzyme A diphosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an acyl-coenzyme A + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+." [PMID:32915949]
comment: This term has been pbsoleted because it represents the same activity as CoA pyrophosphatase activity ; GO:0010945.
synonym: "acyl-CoA diphosphatase activity" EXACT []
synonym: "acyl-CoA pyrophosphatase activity" EXACT []
synonym: "acyl-coenzyme A pyrophosphatase activity" EXACT []
is_obsolete: true
replaced_by: GO:0010945

[Term]
id: GO:0106400
name: double-strand break repair via transcription-associated homologous recombination
namespace: biological_process
def: "A mechanism of homologous recombination and DNA repair in which transcript RNA is used as a template for DSB repair." [PMID:25186730]
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0106402
name: Lewis x epitope biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a Lewis x epitope, a trisaccharide (beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system. The related Lewis x epitope is formed by alpha(1,3) fucosylation of the N-acetylglucosaminyl residue of a type 2 histo-blood group antigen precursor disaccharide." [PMID:16973732, PMID:23000574]
synonym: "sialyl-Lewis X biosynthetic process" RELATED []
synonym: "sLeX biosynthetic process" RELATED []
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0106405
name: isoprenoid diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the dephosphorylation of isoprenoid diphosphates." [PMID:33246356]
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0106407
name: Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H2O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose." [EC:3.2.1.207, PMID:30389790]
comment: Trims Glc alpha 1,3 Glc bond in Glc2Man9GlcNAc2 oligosaccharide in inmature glycoproteins.
synonym: "glucosidase II" BROAD []
xref: EC:3.2.1.207
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0106408
name: diadenylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate." [PMID:30884174, RHEA:35655]
synonym: "cyclic-di-AMP synthase" EXACT [EC:2.7.7.85]
xref: EC:2.7.7.85
xref: MetaCyc:RXN-14338
xref: RHEA:35655
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0106409
name: cyclic-di-AMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+." [PMID:21909268, RHEA:54420]
xref: EC:3.1.4.59
xref: MetaCyc:RXN-19814
xref: RHEA:54420
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0106410
name: box C/D sno(s)RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of a box C/D RNA molecule." [PMID:34352089]
is_a: GO:0034963 ! box C/D sno(s)RNA processing
is_a: GO:0180031 ! snoRNA 2,2,7-trimethylguanosine (TMG) capping

[Term]
id: GO:0106411
name: XMP 5'-nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine." [PMID:34824243, RHEA:28530]
xref: MetaCyc:XMPXAN-RXN
xref: RHEA:28530
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0106413
name: RNA dihydrouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA-uracil + NAD(P)+ = RNA-dihydrouridine + NAD(P)H + H+." [PMID:12581659, PMID:25073379]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0106414
name: mRNA dihydrouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+." [PMID:34798057]
is_a: GO:0106413 ! RNA dihydrouridine synthase activity

[Term]
id: GO:0106415
name: muramoyltetrapeptide carboxypeptidase activity
namespace: molecular_function
def: "GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine." [PMID:10428950, PMID:15361936]
xref: EC:3.4.17.13
xref: RHEA:48688
is_a: GO:0004180 ! carboxypeptidase activity

[Term]
id: GO:0106417
name: dopaminechrome tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole." [PMID:34388859, RHEA:70199]
xref: RHEA:70199
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0106418
name: UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate." [PMID:17384195, PMID:8808921, RHEA:29563]
synonym: "murein peptide ligase" RELATED [EC:6.3.2.45]
xref: EC:6.3.2.45
xref: RHEA:29563
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0106419
name: NAD-dependent protein lipoamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl-[protein] + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:25525879, RHEA:63640]
xref: EC:2.3.1.313
xref: MetaCyc:RXN-22964
xref: RHEA:63640
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0106420
name: NAD-dependent protein biotinidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl-[protein] + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:25525879, RHEA:70479]
xref: RHEA:70479
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0106421
name: L-glutamate:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out)." [PMID:29273736]
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0106422
name: carotenoid isomerooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal." [PMID:19020100, PMID:19889630, RHEA:33931]
xref: EC:1.13.11.65
xref: RHEA:33931
is_a: GO:0010436 ! carotenoid dioxygenase activity

[Term]
id: GO:0106423
name: tubulin-tyrosine carboxypeptidase
namespace: molecular_function
def: "Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine." [PMID:29146869, PMID:35482892, RHEA:57444]
synonym: "tubulinyl-Tyr carboxypeptidase" EXACT [EC:3.4.17.17]
xref: EC:3.4.17.17
xref: RHEA:57444
is_a: GO:0004181 ! metallocarboxypeptidase activity

[Term]
id: GO:0106425
name: 3,4-dihydroxyphenylacetaldehyde synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-dopa + O2 + H2O + H+ = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH(4)+ + H2O2." [PMID:21283636, RHEA:55524]
synonym: "DHPAA synthase" EXACT []
xref: EC:4.1.1.107
xref: RHEA:55524
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0106426
name: regulation of kainate selective glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway." [PMID:12597860]
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
relationship: regulates GO:0098991 ! kainate selective glutamate receptor signaling pathway

[Term]
id: GO:0106427
name: negative regulation of kainate selective glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway." [PMID:12597860]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0106426 ! regulation of kainate selective glutamate receptor signaling pathway

[Term]
id: GO:0106428
name: positive regulation of kainate selective glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway." [PMID:12597860]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0106426 ! regulation of kainate selective glutamate receptor signaling pathway

[Term]
id: GO:0106429
name: 11-cis-retinol dehydrogenase
namespace: molecular_function
def: "Catalysis of the reaction:11-cis-retinol-[retinal-binding-protein] + NAD+ = 11-cis-retinal-[retinol-binding-protein] + NADH." [RHEA:55668]
xref: EC:1.1.1.315
xref: RHEA:55668
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0106430
name: dihydroorotate dehydrogenase (quinone) activity
namespace: molecular_function
def: "(S)-dihydroorotate + a quinone = orotate + a quinol." [RHEA:30187]
xref: EC:1.3.5.2
xref: RHEA:30187
is_a: GO:0004152 ! dihydroorotate dehydrogenase activity
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0106431
name: N6-methyl-(d)ATP hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+." [PMID:32144205]
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0106432
name: queuosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a N-D-queuosine + H2O = queuine + D-ribose." [PMID:35940128]
synonym: "queuosine nucleoside glycosylase" EXACT []
synonym: "tRNA queuosine nucleoside glycosylase" EXACT []
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0106433
name: O6-methyl-dGTP hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+." [PMID:30304478, RHEA:67600]
xref: RHEA:67600
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0106434
name: retinal isomerization
namespace: biological_process
def: "The reactions involved in isomerization of all trans to all cis retnal." [PMID:21447403]
comment: This process term replaces 'retinal isomerase' because the Enzyme Commission has determined that the reaction is known to be catalyzed by a pathway involving multiple steps, catalyzed by EC:1.1.1.300, EC:2.3.1.135, EC:3.1.1.64, and EC:1.1.1.315.
is_a: GO:0042574 ! retinal metabolic process

[Term]
id: GO:0106435
name: carboxylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+." [RHEA:21164]
comment: Note: This covers a broad range of specificity; also hydrolyzes vitamin A esters.
synonym: "ali-esterase activity" RELATED [EC:3.1.1.1]
synonym: "alpha-carboxylesterase activity" NARROW []
synonym: "B-esterase activity" NARROW [EC:3.1.1.1]
synonym: "cocaine esterase" NARROW [EC:3.1.1.1]
synonym: "nonspecific carboxylesterase activity" RELATED []
synonym: "procaine esterase" NARROW [] {comment="EC:3.1.1.1"}
synonym: "serine esterase activity" NARROW []
synonym: "triacetin esterase" NARROW []
synonym: "vitamin A esterase" NARROW []
xref: EC:3.1.1.1
xref: MetaCyc:CARBOXYLESTERASE-RXN
xref: Reactome:R-HSA-9619024 "CES1 trimer hydrolyses ACEI pro-drugs to ACEIs"
xref: Reactome:R-HSA-9727567 "CES1 hydrolyses sacubitril to sacubitrilat"
xref: Reactome:R-HSA-9749647 "CES2 hydrolyzes ASA-"
xref: RHEA:21164
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0106436
name: glutathione-dependent sulfide quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a quinone + glutathione + H+ + hydrogen sulfide = a quinol + S-sulfanylglutathione." [RHEA:55156]
synonym: "eukaryotic sulfide quinone oxidoreductase" RELATED []
xref: EC:1.8.5.8
xref: RHEA:55156
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0106437
name: protein-glutamic acid ligase activity, initiating
namespace: molecular_function
def: "Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H+ + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate." [PMID:32747782, RHEA:60144]
xref: RHEA:60144
is_a: GO:0070739 ! protein-glutamic acid ligase activity

[Term]
id: GO:0106438
name: protein-glutamic acid ligase activity, elongating
namespace: molecular_function
def: "Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H+ + phosphate." [PMID:32747782, RHEA:60148]
xref: RHEA:60148
is_a: GO:0070739 ! protein-glutamic acid ligase activity

[Term]
id: GO:0106439
name: L-lysine:L-arginine antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)." [PMID:10903140, RHEA:70827]
comment: L-arginine:L-lysine antiporter activity
xref: RHEA:70827
is_a: GO:0015189 ! L-lysine transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0061459 ! L-arginine transmembrane transporter activity

[Term]
id: GO:0110001
name: toxin-antitoxin complex
namespace: cellular_component
def: "A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon." [GOC:bhm, PMID:16109374, PMID:25093388]
comment: An example is YoeB (P69348) in Escherichia coli in PMID:16109374 (inferred by direct evidence).
is_a: GO:0017053 ! transcription repressor complex

[Term]
id: GO:0110002
name: regulation of tRNA methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation." [GOC:vw, PMID:23074192]
is_a: GO:2000235 ! regulation of tRNA processing
relationship: regulates GO:0030488 ! tRNA methylation

[Term]
id: GO:0110003
name: regulation of tRNA C5-cytosine methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA C5-cytosine methylation." [GOC:vw, PMID:23074192]
is_a: GO:0110002 ! regulation of tRNA methylation
relationship: regulates GO:0002946 ! tRNA C5-cytosine methylation

[Term]
id: GO:0110004
name: positive regulation of tRNA methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA methylation." [GOC:vw, PMID:23074192]
is_a: GO:0110002 ! regulation of tRNA methylation
is_a: GO:2000237 ! positive regulation of tRNA processing
relationship: positively_regulates GO:0030488 ! tRNA methylation

[Term]
id: GO:0110005
name: positive regulation of tRNA C5-cytosine methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA C5-cytosine methylation." [GOC:vw, PMID:23074192]
is_a: GO:0110003 ! regulation of tRNA C5-cytosine methylation
is_a: GO:0110004 ! positive regulation of tRNA methylation
relationship: positively_regulates GO:0002946 ! tRNA C5-cytosine methylation

[Term]
id: GO:0110008
name: obsolete ncRNA deadenylation
namespace: biological_process
def: "OBSOLETE. Shortening of the poly(A) tail of a nuclear-transcribed ncRNA." [GOC:vw]
comment: The reason for obsoletion is that this term represents a molecular function.
is_obsolete: true
replaced_by: GO:0016070

[Term]
id: GO:0110009
name: formin-nucleated actin cable organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a formin-nucleated actin cable." [GOC:mah]
is_a: GO:0061572 ! actin filament bundle organization

[Term]
id: GO:0110010
name: basolateral protein secretion
namespace: biological_process
def: "The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base." [GOC:ha, PMID:27404358]
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0110011
name: regulation of basement membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358]
is_a: GO:1903053 ! regulation of extracellular matrix organization
relationship: regulates GO:0071711 ! basement membrane organization

[Term]
id: GO:0110012
name: protein localization to P-body
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a P-body." [GOC:mah, PMID:28031482]
synonym: "protein localisation to P-body" EXACT [GOC:mah]
synonym: "protein localization to cytoplasmic mRNA processing body" EXACT []
synonym: "protein localization to P body" EXACT []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0110013
name: positive regulation of aggregation involved in sorocarp development
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:rjd, PMID:28257811]
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development
relationship: positively_regulates GO:0031152 ! aggregation involved in sorocarp development

[Term]
id: GO:0110014
name: negative regulation of aggregation involved in sorocarp development
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:rjd, PMID:28257811]
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development
relationship: negatively_regulates GO:0031152 ! aggregation involved in sorocarp development

[Term]
id: GO:0110015
name: positive regulation of elastin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0060310 ! regulation of elastin catabolic process
is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process
relationship: positively_regulates GO:0060309 ! elastin catabolic process

[Term]
id: GO:0110016
name: B-WICH complex
namespace: cellular_component
def: "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself." [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184]
comment: An example is BAZ1B (Q9UIG0) in human in PMID:16603771 (by IPI).
is_a: GO:0070603 ! SWI/SNF superfamily-type complex
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0110017
name: cap-independent translational initiation of linear mRNA
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [GOC:kmv]
is_a: GO:0002190 ! cap-independent translational initiation

[Term]
id: GO:0110018
name: cap-independent translational initiation of circular RNA
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate circRNA translation." [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082]
synonym: "cap-independent translational initiation of circRNA" EXACT []
is_a: GO:0002190 ! cap-independent translational initiation

[Term]
id: GO:0110019
name: IRES-dependent translational initiation of circular RNA
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation." [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082]
synonym: "IRES-dependent translational initiation of circRNA" EXACT []
is_a: GO:0110018 ! cap-independent translational initiation of circular RNA

[Term]
id: GO:0110020
name: regulation of actomyosin structure organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
relationship: regulates GO:0031032 ! actomyosin structure organization

[Term]
id: GO:0110021
name: cardiac muscle myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0051450 ! myoblast proliferation

[Term]
id: GO:0110022
name: regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:2000291 ! regulation of myoblast proliferation
relationship: regulates GO:0110021 ! cardiac muscle myoblast proliferation

[Term]
id: GO:0110023
name: negative regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation
is_a: GO:2000818 ! negative regulation of myoblast proliferation
relationship: negatively_regulates GO:0110021 ! cardiac muscle myoblast proliferation

[Term]
id: GO:0110024
name: positive regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation
is_a: GO:2000288 ! positive regulation of myoblast proliferation
relationship: positively_regulates GO:0110021 ! cardiac muscle myoblast proliferation

[Term]
id: GO:0110025
name: DNA strand resection involved in replication fork processing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing." [GOC:mah, PMID:28475874]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0031297 ! replication fork processing

[Term]
id: GO:0110026
name: regulation of DNA strand resection involved in replication fork processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0110025 ! DNA strand resection involved in replication fork processing

[Term]
id: GO:0110027
name: negative regulation of DNA strand resection involved in replication fork processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874]
is_a: GO:0110026 ! regulation of DNA strand resection involved in replication fork processing
is_a: GO:2000104 ! negative regulation of DNA-templated DNA replication
relationship: negatively_regulates GO:0110025 ! DNA strand resection involved in replication fork processing

[Term]
id: GO:0110028
name: positive regulation of mitotic spindle organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle organization." [GOC:bhm, PMID:17576815]
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0060236 ! regulation of mitotic spindle organization
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0110029
name: negative regulation of meiosis I
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:vw]
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
is_a: GO:0060631 ! regulation of meiosis I
relationship: negatively_regulates GO:0007127 ! meiosis I

[Term]
id: GO:0110030
name: regulation of G2/MI transition of meiotic cell cycle
namespace: biological_process
def: "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw]
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition
relationship: regulates GO:0008315 ! G2/MI transition of meiotic cell cycle

[Term]
id: GO:0110031
name: negative regulation of G2/MI transition of meiotic cell cycle
namespace: biological_process
def: "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408]
is_a: GO:0110030 ! regulation of G2/MI transition of meiotic cell cycle
is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition
is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition
relationship: negatively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle

[Term]
id: GO:0110032
name: positive regulation of G2/MI transition of meiotic cell cycle
namespace: biological_process
def: "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408]
is_a: GO:0110030 ! regulation of G2/MI transition of meiotic cell cycle
is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition
is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition
relationship: positively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle

[Term]
id: GO:0110033
name: regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway, the series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:al, PMID:24297439]
synonym: "regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
is_a: GO:1902659 ! regulation of glucose mediated signaling pathway
relationship: regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway

[Term]
id: GO:0110034
name: negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway." [GOC:al, PMID:24297439]
synonym: "negative regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT []
is_a: GO:0106072 ! negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
is_a: GO:0110033 ! regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
is_a: GO:1902660 ! negative regulation of glucose mediated signaling pathway
relationship: negatively_regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway

[Term]
id: GO:0110035
name: rDNA spacer replication fork barrier binding, bending
namespace: molecular_function
def: "The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:al, GOC:vw, PMID:27035982]
is_a: GO:0043110 ! rDNA spacer replication fork barrier binding
is_a: GO:0044374 ! sequence-specific DNA binding, bending

[Term]
id: GO:0110036
name: C2 domain binding
namespace: molecular_function
def: "Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes." [GOC:sl, PMID:24882364]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0110037
name: regulation of nematode male tail tip morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nematode male tail tip morphogenesis, the process in which the anatomical structure of the adult male tail tip is generated and organized." [GOC:rz, PMID:28068334]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0045138 ! nematode male tail tip morphogenesis

[Term]
id: GO:0110038
name: negative regulation of nematode male tail tip morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis." [GOC:rz, PMID:28068334]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0110037 ! regulation of nematode male tail tip morphogenesis
relationship: negatively_regulates GO:0045138 ! nematode male tail tip morphogenesis

[Term]
id: GO:0110039
name: positive regulation of nematode male tail tip morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis." [GOC:rz, PMID:28068334]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0110037 ! regulation of nematode male tail tip morphogenesis
relationship: positively_regulates GO:0045138 ! nematode male tail tip morphogenesis

[Term]
id: GO:0110040
name: nematode pharynx morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nematode pharynx are generated and organized." [GOC:rz, PMID:20805556]
is_a: GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0110041
name: regulation of nematode pharynx morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nematode pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized." [GOC:rz, PMID:20805556]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0110040 ! nematode pharynx morphogenesis

[Term]
id: GO:0110042
name: negative regulation of nematode pharynx morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nematode pharynx morphogenesis." [GOC:rz, PMID:20805556]
is_a: GO:0110041 ! regulation of nematode pharynx morphogenesis
is_a: GO:0110111 ! negative regulation of animal organ morphogenesis
relationship: negatively_regulates GO:0110040 ! nematode pharynx morphogenesis

[Term]
id: GO:0110043
name: positive regulation of nematode pharynx morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nematode pharynx morphogenesis." [GOC:rz, PMID:20805556]
is_a: GO:0110041 ! regulation of nematode pharynx morphogenesis
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
relationship: positively_regulates GO:0110040 ! nematode pharynx morphogenesis

[Term]
id: GO:0110044
name: regulation of cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:al, PMID:17674143]
synonym: "sexual differentiation" RELATED [PMID:30922219, PMID:32788233]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051445 ! regulation of meiotic cell cycle
relationship: regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle

[Term]
id: GO:0110045
name: negative regulation of cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:al, PMID:17674143]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:0110044 ! regulation of cell cycle switching, mitotic to meiotic cell cycle
relationship: negatively_regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle

[Term]
id: GO:0110046
name: obsolete signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
def: "OBSOLETE. A signal transduction process that contributes to cell cycle switching, mitotic to meiotic cell cycle." [GOC:al, PMID:17674143]
comment: The reason for obsoletion is that this term represents a mix of different pathways.
is_obsolete: true

[Term]
id: GO:0110050
name: deaminated glutathione amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine." [GOC:ka, PMID:28373563, RHEA:54532]
comment: N-(4-oxoglutarate)-L-cysteinylglycine = deaminated glutathione
xref: EC:3.5.1.128
xref: RHEA:54532
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0110051
name: metabolite repair
namespace: biological_process
def: "A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0110052
name: toxic metabolite repair
namespace: biological_process
def: "A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, GOC:vw, PMID:23334546]
is_a: GO:0110051 ! metabolite repair
is_a: GO:1990748 ! cellular detoxification

[Term]
id: GO:0110053
name: regulation of actin filament organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: regulates GO:0007015 ! actin filament organization

[Term]
id: GO:0110054
name: regulation of actin filament annealing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:10585915, PMID:11575927, PMID:15743909, PMID:19244341]
is_a: GO:0110053 ! regulation of actin filament organization

[Term]
id: GO:0110055
name: negative regulation of actin filament annealing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:15743909]
is_a: GO:0110054 ! regulation of actin filament annealing

[Term]
id: GO:0110056
name: positive regulation of actin filament annealing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:10585915, PMID:11575927, PMID:19244341]
is_a: GO:0110054 ! regulation of actin filament annealing

[Term]
id: GO:0110057
name: regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045601 ! regulation of endothelial cell differentiation
relationship: regulates GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0110058
name: positive regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045603 ! positive regulation of endothelial cell differentiation
is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation
relationship: positively_regulates GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0110059
name: negative regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation
relationship: negatively_regulates GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0110061
name: regulation of angiotensin-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0038166 ! angiotensin-activated signaling pathway

[Term]
id: GO:0110062
name: negative regulation of angiotensin-activated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619]
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:0110061 ! regulation of angiotensin-activated signaling pathway
relationship: negatively_regulates GO:0038166 ! angiotensin-activated signaling pathway

[Term]
id: GO:0110063
name: positive regulation of angiotensin-activated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:0110061 ! regulation of angiotensin-activated signaling pathway
relationship: positively_regulates GO:0038166 ! angiotensin-activated signaling pathway

[Term]
id: GO:0110064
name: lncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length." [GOC:al, PMID:24493644]
synonym: "lncRNA breakdown" EXACT []
synonym: "lncRNA catabolism" EXACT []
synonym: "lncRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0110065
name: regulation of interphase mitotic telomere clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic telomere clustering during interphase." [GOC:vw, PMID:25778919]
synonym: "regulation of mitotic telomere clustering during interphase" EXACT []
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0120110 ! interphase mitotic telomere clustering

[Term]
id: GO:0110066
name: negative regulation of interphase mitotic telomere clustering
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase." [GOC:vw, PMID:25778919]
synonym: "negative regulation of mitotic telomere clustering during interphase" EXACT []
synonym: "telomere dispersion during interphase" EXACT [GOC:vw, PMID:25778919]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0110065 ! regulation of interphase mitotic telomere clustering
relationship: negatively_regulates GO:0120110 ! interphase mitotic telomere clustering

[Term]
id: GO:0110067
name: ammonium transmembrane transporter complex
namespace: cellular_component
def: "High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other." [GOC:bhm, PMID:17026539, PMID:23463773]
synonym: "AMT1 complex" NARROW [GOC:bhm]
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:0110068
name: glucosylglycerate phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate." [GOC:imk, PMID:28754708]
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity

[Term]
id: GO:0110069
name: syncytial embryo cellularization
namespace: biological_process
def: "The separation of a syncytial embryo into individual cells." [GOC:ha, PMID:27226317]
is_a: GO:0007349 ! cellularization
is_a: GO:0051301 ! cell division
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0110070
name: cellularization cleavage furrow
namespace: cellular_component
def: "A plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells." [GOC:ha, PMID:27226317]
is_a: GO:0098590 ! plasma membrane region

[Term]
id: GO:0110071
name: cellularization cleavage furrow invagination front
namespace: cellular_component
def: "The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane." [GOC:ha, PMID:27226317]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0110070 ! cellularization cleavage furrow

[Term]
id: GO:0110072
name: apical constriction involved in ventral furrow formation
namespace: biological_process
def: "The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [GOC:ha, PMID:28495958]
is_a: GO:0003384 ! apical constriction involved in gastrulation
relationship: part_of GO:0007370 ! ventral furrow formation

[Term]
id: GO:0110073
name: regulation of apical constriction involved in ventral furrow formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apical constriction involved in ventral furrow formation." [GOC:ha, PMID:28495958]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:1903115 ! regulation of actin filament-based movement
relationship: regulates GO:0110072 ! apical constriction involved in ventral furrow formation

[Term]
id: GO:0110074
name: positive regulation of apical constriction involved in ventral furrow formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation." [GOC:ha, PMID:28495958]
is_a: GO:0110073 ! regulation of apical constriction involved in ventral furrow formation
is_a: GO:1903116 ! positive regulation of actin filament-based movement
relationship: positively_regulates GO:0110072 ! apical constriction involved in ventral furrow formation

[Term]
id: GO:0110075
name: regulation of ferroptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferroptosis." [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465]
is_a: GO:0043067 ! regulation of programmed cell death
relationship: regulates GO:0097707 ! ferroptosis

[Term]
id: GO:0110076
name: negative regulation of ferroptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis." [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0110075 ! regulation of ferroptosis
relationship: negatively_regulates GO:0097707 ! ferroptosis

[Term]
id: GO:0110077
name: vesicle-mediated intercellular transport
namespace: biological_process
def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916]
synonym: "endosomal trafficking" RELATED []
is_a: GO:0010496 ! intercellular transport
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0110078
name: TTT Hsp90 cochaperone complex
namespace: cellular_component
def: "A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family." [PMID:20810650, PMID:22505622, PMID:28827813, PMID:34233195]
synonym: "Tel2-Tti1-Tti2" EXACT [GOC:lnp, PMID:28827813]
synonym: "TELO2-TTI1-TTI2" EXACT [GOC:lnp]
synonym: "Triple T complex" EXACT [GOC:lnp, PMID:20810650]
synonym: "TTT complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0110079
name: regulation of placenta blood vessel development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]
is_a: GO:1901342 ! regulation of vasculature development
relationship: regulates GO:0060674 ! placenta blood vessel development

[Term]
id: GO:0110080
name: positive regulation of placenta blood vessel development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0110079 ! regulation of placenta blood vessel development
relationship: positively_regulates GO:0060674 ! placenta blood vessel development

[Term]
id: GO:0110081
name: negative regulation of placenta blood vessel development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0110079 ! regulation of placenta blood vessel development
relationship: negatively_regulates GO:0060674 ! placenta blood vessel development

[Term]
id: GO:0110082
name: regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:1901900 ! regulation of protein localization to cell division site
relationship: regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

[Term]
id: GO:0110083
name: positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0110082 ! regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

[Term]
id: GO:0110084
name: negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550]
is_a: GO:0110082 ! regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

[Term]
id: GO:0110085
name: mitotic actomyosin contractile ring
namespace: cellular_component
def: "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:vw, PMID:27505246]
is_a: GO:0005826 ! actomyosin contractile ring

[Term]
id: GO:0110086
name: meiotic actomyosin contractile ring
namespace: cellular_component
def: "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the meiotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the meiotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In fungal cells, the meiotic contractile ring forms beneath the plasma membrane of the prospore envelope in preparation for completing cytokinesis." [GOC:vw, PMID:22526418]
is_a: GO:0005826 ! actomyosin contractile ring

[Term]
id: GO:0110087
name: obsolete suppression by virus of host protease activator activity
namespace: biological_process
def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protease activator activity." [PMID:23303392]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0110088
name: hippocampal neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process that occurs in a hippocampal neuron." [GOC:sl, PMID:18940801]
is_a: GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0110089
name: regulation of hippocampal neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801]
is_a: GO:0043523 ! regulation of neuron apoptotic process
relationship: regulates GO:0110088 ! hippocampal neuron apoptotic process

[Term]
id: GO:0110090
name: positive regulation of hippocampal neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801]
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process
relationship: positively_regulates GO:0110088 ! hippocampal neuron apoptotic process

[Term]
id: GO:0110091
name: negative regulation of hippocampal neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801]
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process
relationship: negatively_regulates GO:0110088 ! hippocampal neuron apoptotic process

[Term]
id: GO:0110092
name: nucleus leading edge
namespace: cellular_component
def: "The area of a motile nucleus closest to the direction of movement." [GOC:al, GOC:mah, GOC:vw, PMID:15030757, PMID:24335254]
synonym: "horsetail nucleus leading edge" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0110093
name: nucleus lagging edge
namespace: cellular_component
def: "The area of a motile nucleus furthest from the direction of movement." [GOC:kmv, PMID:24335254]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0110094
name: polyphosphate-mediated signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal." [GOC:rjd, PMID:27519410, PMID:28584190]
synonym: "polyphosphate signaling" EXACT [GOC:rjd]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0110095
name: cellular detoxification of aldehyde
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw, PMID:25656103]
is_a: GO:1990748 ! cellular detoxification
relationship: part_of GO:0110096 ! cellular response to aldehyde

[Term]
id: GO:0110096
name: cellular response to aldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus." [GOC:vw, PMID:25656103]
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0110097
name: regulation of calcium import into the mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037]
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
relationship: regulates GO:0036444 ! calcium import into the mitochondrion

[Term]
id: GO:0110098
name: positive regulation of calcium import into the mitochondrion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037]
is_a: GO:0110097 ! regulation of calcium import into the mitochondrion
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
relationship: positively_regulates GO:0036444 ! calcium import into the mitochondrion

[Term]
id: GO:0110099
name: negative regulation of calcium import into the mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion." [GOC:sl, PMID:24085037]
is_a: GO:0110097 ! regulation of calcium import into the mitochondrion
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
relationship: negatively_regulates GO:0036444 ! calcium import into the mitochondrion

[Term]
id: GO:0110100
name: spindle pole body separation
namespace: biological_process
def: "The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble." [GOC:vw]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051300 ! spindle pole body organization

[Term]
id: GO:0110101
name: L-valine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-valine into the vacuole across the vacuolar membrane." [GOC:al, PMID:20944394]
is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole
is_a: GO:1903785 ! L-valine transmembrane transport

[Term]
id: GO:0110102
name: ribulose bisphosphate carboxylase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex." [GOC:krc, GOC:tb, PMID:29396988, PMID:29589905]
synonym: "RuBisCO assembly" EXACT [GOC:krc]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0110103
name: RNA polymerase II termination complex
namespace: cellular_component
def: "A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end." [GOC:lnp, PMID:23200120, PMID:25722373]
comment: In S. cerevisiae, this complex is formed by RAI1 and RAT1; in H. sapiens it is formed by Twi12, Xrn2 and Tan1.
synonym: "TXT complex" EXACT [PMID:23084833]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1905354 ! exoribonuclease complex

[Term]
id: GO:0110104
name: mRNA alternative polyadenylation
namespace: biological_process
def: "The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals)." [GOC:ans, PMID:28453393, PMID:29276085]
is_a: GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0110105
name: mRNA cleavage and polyadenylation specificity factor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex." [GOC:mah, PMID:27401558]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0110107
name: regulation of imaginal disc-derived wing vein specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007474 ! imaginal disc-derived wing vein specification

[Term]
id: GO:0110108
name: positive regulation of imaginal disc-derived wing vein specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0110107 ! regulation of imaginal disc-derived wing vein specification
relationship: positively_regulates GO:0007474 ! imaginal disc-derived wing vein specification

[Term]
id: GO:0110109
name: negative regulation of imaginal disc-derived wing vein specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0110107 ! regulation of imaginal disc-derived wing vein specification
relationship: negatively_regulates GO:0007474 ! imaginal disc-derived wing vein specification

[Term]
id: GO:0110110
name: positive regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: positively_regulates GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0110111
name: negative regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: negatively_regulates GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:0110112
name: regulation of lipid transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]
subset: gocheck_obsoletion_candidate
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032409 ! regulation of transporter activity

[Term]
id: GO:0110113
name: positive regulation of lipid transporter activity
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]
subset: gocheck_obsoletion_candidate
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0110112 ! regulation of lipid transporter activity

[Term]
id: GO:0110114
name: negative regulation of lipid transporter activity
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]
subset: gocheck_obsoletion_candidate
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0110112 ! regulation of lipid transporter activity

[Term]
id: GO:0110115
name: Cdr2 medial cortical node complex
namespace: cellular_component
def: "A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase." [GOC:vw, PMID:29514920]
synonym: "interphase cortical node" EXACT [GOC:vw]
synonym: "interphase node" EXACT [GOC:vw]
is_a: GO:1902911 ! protein kinase complex
relationship: part_of GO:0071341 ! medial cortical node

[Term]
id: GO:0110116
name: regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0110117
name: positive regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
relationship: positively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0110118
name: negative regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
relationship: negatively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0110119
name: positive regulation of very-low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of very-low-density lipoprotein particle clearance." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:25510864]
is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance
is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance
relationship: positively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance

[Term]
id: GO:0110120
name: gamma-tubulin complex localization to nuclear side of mitotic spindle pole body
namespace: biological_process
def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body." [GOC:vw, PMID:19942852]
is_a: GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body

[Term]
id: GO:0110121
name: gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body
namespace: biological_process
def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body." [GOC:vw, PMID:19001497]
is_a: GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body

[Term]
id: GO:0110122
name: myotube cell migration
namespace: biological_process
def: "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse." [GOC:ha, PMID:29122742]
is_a: GO:0014812 ! muscle cell migration

[Term]
id: GO:0110123
name: regulation of myotube cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0110122 ! myotube cell migration

[Term]
id: GO:0110124
name: positive regulation of myotube cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0110123 ! regulation of myotube cell migration
relationship: positively_regulates GO:0110122 ! myotube cell migration

[Term]
id: GO:0110125
name: negative regulation of myotube cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0110123 ! regulation of myotube cell migration
relationship: negatively_regulates GO:0110122 ! myotube cell migration

[Term]
id: GO:0110126
name: phloem loading
namespace: biological_process
def: "The process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:lr, PMID:19025382]
is_a: GO:0010233 ! phloem transport

[Term]
id: GO:0110127
name: phloem unloading
namespace: biological_process
def: "The process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues." [GOC:lr, PMID:19025382]
is_a: GO:0010233 ! phloem transport

[Term]
id: GO:0110128
name: phloem sucrose unloading
namespace: biological_process
def: "The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues." [GOC:lr, PMID:30018170]
is_a: GO:0015770 ! sucrose transport
is_a: GO:0110127 ! phloem unloading

[Term]
id: GO:0110129
name: obsolete SHREC2 complex
namespace: cellular_component
def: "OBSOLETE. A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2." [GOC:mah, PMID:19111658]
comment: This term was added in error.
is_obsolete: true

[Term]
id: GO:0110130
name: ribitol-5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate." [GOC:rn, PMID:30240188]
xref: RHEA:47648
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0110131
name: Aim21-Tda2 complex
namespace: cellular_component
def: "A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables." [GOC:rn, PMID:28706108, PMID:29467252]
synonym: "Aim21/Tda2 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030479 ! actin cortical patch

[Term]
id: GO:0110132
name: obsolete regulation of CRISPR-cas system
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a CRISPR-cas system." [PMID:30190307, PMID:30190308]
comment: This term was obsoleted because it does not accurately capture the process described in the literature.
is_obsolete: true

[Term]
id: GO:0110133
name: obsolete negative regulation of CRISPR-cas system
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a CRISPR-cas system." [PMID:30190307, PMID:30190308]
comment: This term was obsoleted because it does not accurately capture the process described in the literature.
is_obsolete: true
consider: GO:0098672

[Term]
id: GO:0110134
name: meiotic drive
namespace: biological_process
def: "A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis." [GOC:mah, PMID:26920473, PMID:29322557, PMID:29499907]
subset: goslim_pombe
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0110135
name: Norrin signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state." [GOC:BHF, GOC:rl, PMID:15035989, PMID:17955262]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0110136
name: protein-RNA complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex." [GOC:rn, PMID:19737519, PMID:20542003, PMID:24240281]
synonym: "protein-RNA complex remodelling" EXACT []
is_a: GO:0034367 ! protein-containing complex remodeling
is_a: GO:0071826 ! protein-RNA complex organization

[Term]
id: GO:0110137
name: regulation of imaginal disc-derived leg joint morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis, the process in which the anatomical structure of the imaginal disc-derived leg joint is generated and organized." [GOC:ha, PMID:25329825]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0007480 ! imaginal disc-derived leg morphogenesis

[Term]
id: GO:0110138
name: positive regulation of imaginal disc-derived leg joint morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis." [GOC:ha, PMID:25329825]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0110137 ! regulation of imaginal disc-derived leg joint morphogenesis
relationship: positively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis

[Term]
id: GO:0110139
name: negative regulation of imaginal disc-derived leg joint morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis." [GOC:ha, PMID:25329825]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0110137 ! regulation of imaginal disc-derived leg joint morphogenesis
relationship: negatively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis

[Term]
id: GO:0110140
name: flagellum attachment zone organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum attachment zone. FAZ is a network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species." [GOC:ach, PMID:26776656]
synonym: "FAZ organization" EXACT []
synonym: "flagellum attachment zone organisation" EXACT []
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0110141
name: L-glutamate import into mitochondrion
namespace: biological_process
def: "The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix." [GOC:vw, PMID:30297026]
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:0110142
name: ubiquinone biosynthesis complex
namespace: cellular_component
def: "A protein complex composed of enzymes and accessory factors of the ubiquinone (CoQ) biosynthesis pathway. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. In eukaryotes, the complex is located on the matrix face of the inner mitochondrial membrane and includes COQ3, COQ4, COQ5, COQ6, COQ7, COQ9." [GOC:imk, PMID:27060254, PMID:28927698, PMID:30686758]
synonym: "complex Q" EXACT [PMID:28927698]
synonym: "CoQ Biosynthetic Complex" EXACT [PMID:28927698]
synonym: "CoQ metabolon" EXACT [PMID:28927698]
synonym: "CoQ-synthome" EXACT [PMID:28927698]
synonym: "Ubi complex" EXACT [PMID:30686758]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0110143
name: magnetosome
namespace: cellular_component
def: "A membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria. Magnetosomes form linear chains that align along the cellular motility axis at midcell and function in bacterial navigation along the Earth's magnetic field. They are formed by invagination of the cell inner membrane; in some species they remain connected to the inner membrane, in others they pinch off to form independent intracellular vesicles." [GOC:aa, PMID:27620945]
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0110144
name: obsolete magnetosome part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a magnetosome, a membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria." [GOC:aa, PMID:27620945]
is_obsolete: true
consider: GO:0110143

[Term]
id: GO:0110145
name: magnetosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a magnetosome." [GOC:aa, PMID:27620945]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0110143 ! magnetosome

[Term]
id: GO:0110146
name: magnetosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a magnetosome." [GOC:aa, PMID:27620945]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0110143 ! magnetosome

[Term]
id: GO:0110147
name: protein maturation by nickel ion transfer
namespace: biological_process
def: "A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation." [GOC:al, PMID:24115911]
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0110148
name: obsolete biomineralization
namespace: biological_process
def: "OBSOLETE. The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products." [GOC:aa, PMID:24395694, PMID:28229486]
comment: This term was obsoleted because it grouped multicellular organism processes and cellular processes.
synonym: "biomineral formation" NARROW []
synonym: "biomineralisation" EXACT []
synonym: "mineralisation" EXACT []
synonym: "mineralization" EXACT []
xref: Wikipedia:Biomineralization
is_obsolete: true

[Term]
id: GO:0110149
name: obsolete regulation of biomineralization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051]
comment: This term was obsoleted because it grouped multicellular organism processes and cellular processes.
synonym: "regulation of biomineral formation" NARROW []
synonym: "regulation of biomineralisation" EXACT []
synonym: "regulation of mineralisation" EXACT []
synonym: "regulation of mineralization" EXACT []
is_obsolete: true

[Term]
id: GO:0110150
name: obsolete negative regulation of biomineralization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051]
comment: This term was obsoleted because it grouped multicellular organism processes and cellular processes.
synonym: "negative regulation of biomineral formation" NARROW []
synonym: "negative regulation of biomineralisation" EXACT []
synonym: "negative regulation of mineralisation" EXACT []
synonym: "negative regulation of mineralization" EXACT []
is_obsolete: true

[Term]
id: GO:0110151
name: obsolete positive regulation of biomineralization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051]
comment: This term was obsoleted because it grouped multicellular organism processes and cellular processes.
synonym: "positive regulation of biomineral formation" NARROW []
synonym: "positive regulation of biomineralisation" EXACT []
synonym: "positive regulation of mineralisation" EXACT []
synonym: "positive regulation of mineralization" EXACT []
is_obsolete: true

[Term]
id: GO:0110152
name: RNA NAD+-cap (NAD+-forming) hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+." [GOC:sp, PMID:28283058, RHEA:60880]
comment: This reaction specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
synonym: "RNA NAD-cap (NAD-forming) hydrolase activity" EXACT []
xref: RHEA:60880
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0110153
name: RNA NAD-cap (NMN-forming) hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+." [GOC:sp, PMID:25533955, PMID:31101919, RHEA:60876]
comment: This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.
xref: RHEA:60876
is_a: GO:0016462 ! pyrophosphatase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0110154
name: RNA decapping
namespace: biological_process
def: "Cleavage of the 5'-cap of an RNA." [GOC:sp, PMID:25533955, PMID:31101919]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0110155
name: NAD-cap decapping
namespace: biological_process
def: "Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes." [GOC:sp, PMID:25533955, PMID:28283058, PMID:31101919]
is_a: GO:0110154 ! RNA decapping

[Term]
id: GO:0110156
name: mRNA methylguanosine-cap decapping
namespace: biological_process
def: "Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA." [PMID:23287066]
is_a: GO:0016071 ! mRNA metabolic process
is_a: GO:0110154 ! RNA decapping

[Term]
id: GO:0110157
name: reelin complex
namespace: cellular_component
def: "An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain." [GOC:bhm, PMID:21844191, PMID:28887403]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0110158
name: calpain complex
namespace: cellular_component
def: "A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate." [GOC:bhm, PMID:10639123]
synonym: "M-calpain" NARROW []
synonym: "mu-calpain" NARROW []
is_a: GO:0008303 ! caspase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0110159
name: regulation of mitotic spindle formation (spindle phase one)
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw, PMID:27697865]
is_a: GO:1901673 ! regulation of mitotic spindle assembly
relationship: part_of GO:0032888 ! regulation of mitotic spindle elongation
relationship: regulates GO:0061804 ! mitotic spindle formation (spindle phase one)

[Term]
id: GO:0110160
name: negative regulation of mitotic spindle formation (spindle phase one)
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw]
is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one)
is_a: GO:1905831 ! negative regulation of spindle assembly
relationship: negatively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one)

[Term]
id: GO:0110161
name: positive regulation of mitotic spindle formation (spindle phase one)
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw]
is_a: GO:0110028 ! positive regulation of mitotic spindle organization
is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one)
is_a: GO:1905832 ! positive regulation of spindle assembly
relationship: positively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one)

[Term]
id: GO:0110162
name: regulation of mitotic spindle elongation (spindle phase three)
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three)." [GOC:vw, PMID:27697865]
is_a: GO:0032888 ! regulation of mitotic spindle elongation
is_a: GO:0060236 ! regulation of mitotic spindle organization
relationship: regulates GO:0061805 ! mitotic spindle elongation (spindle phase three)

[Term]
id: GO:0110163
name: negative regulation of mitotic spindle elongation (spindle phase three)
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three)." [GOC:vw, PMID:27697865]
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three)
is_a: GO:1902845 ! negative regulation of mitotic spindle elongation
relationship: negatively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three)

[Term]
id: GO:0110164
name: positive regulation of mitotic spindle elongation (spindle phase three)
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three)." [GOC:vw, PMID:27697865]
is_a: GO:0110028 ! positive regulation of mitotic spindle organization
is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three)
is_a: GO:1902846 ! positive regulation of mitotic spindle elongation
relationship: positively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three)

[Term]
id: GO:0110165
name: cellular anatomical structure
namespace: cellular_component
def: "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses." [GOC:kmv]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular anatomical entity" EXACT []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0110166
name: DNA synthesis involved in mitochondrial DNA replication
namespace: biological_process
def: "Any DNA biosynthetic process that is involved in mitochondrial DNA replication." [PMID:28408491, PMID:29931097]
synonym: "DNA biosynthetic process involved in mitochondrial DNA replication" EXACT []
is_a: GO:0032042 ! mitochondrial DNA metabolic process
is_a: GO:0090592 ! DNA synthesis involved in DNA replication
relationship: part_of GO:0006264 ! mitochondrial DNA replication

[Term]
id: GO:0120001
name: apical plasma membrane urothelial plaque
namespace: cellular_component
def: "A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array." [GOC:krc, PMID:21468280, PMID:21887288]
synonym: "asymmetric unit membrane" EXACT []
synonym: "AUM" RELATED []
is_a: GO:0005886 ! plasma membrane
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0120002
name: fusiform vesicle
namespace: cellular_component
def: "A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder." [GOC:krc, PMID:21468280, PMID:21887288]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0120003
name: hinge region between urothelial plaques of apical plasma membrane
namespace: cellular_component
def: "A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane." [GOC:krc, PMID:21468280, PMID:21887288]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0120006
name: regulation of glutamatergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:1905962 ! glutamatergic neuron differentiation

[Term]
id: GO:0120007
name: negative regulation of glutamatergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation
relationship: negatively_regulates GO:1905962 ! glutamatergic neuron differentiation

[Term]
id: GO:0120008
name: positive regulation of glutamatergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation
relationship: positively_regulates GO:1905962 ! glutamatergic neuron differentiation

[Term]
id: GO:0120009
name: intermembrane lipid transfer
namespace: biological_process
def: "The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
is_a: GO:0006869 ! lipid transport
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0120010
name: intermembrane phospholipid transfer
namespace: biological_process
def: "The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0120009 ! intermembrane lipid transfer

[Term]
id: GO:0120011
name: intermembrane sterol transfer
namespace: biological_process
def: "The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
is_a: GO:0015918 ! sterol transport
is_a: GO:0120009 ! intermembrane lipid transfer

[Term]
id: GO:0120012
name: intermembrane sphingolipid transfer
namespace: biological_process
def: "The transport of sphingolipids between membranes in which a sphingolipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0120009 ! intermembrane lipid transfer

[Term]
id: GO:0120013
name: lipid transfer activity
namespace: molecular_function
def: "Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "intermembrane lipid transfer activity" EXACT []
synonym: "lipid carrier activity" EXACT []
xref: Reactome:R-HSA-9856502 "mito-STARD7 transports Q10 to outer mitochondrial membrane"
xref: Reactome:R-HSA-9856510 "STARD7 transports Q10 to plasma membrane"
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0120014
name: phospholipid transfer activity
namespace: molecular_function
def: "Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "intermembrane phospholipid transfer activity" NARROW []
synonym: "phospholipid carrier activity" EXACT []
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0120015
name: sterol transfer activity
namespace: molecular_function
def: "Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "intermembrane sterol transfer activity" NARROW []
synonym: "sterol carrier activity" EXACT []
xref: Reactome:R-HSA-5250531 "ARV1 transports CHOL from ER membrane to plasma membrane"
xref: Reactome:R-HSA-8867667 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane"
xref: Reactome:R-HSA-8868402 "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane"
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0120016
name: sphingolipid transfer activity
namespace: molecular_function
def: "Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "intermembrane sphingolipid transfer activity" NARROW []
synonym: "sphingolipid carrier activity" NARROW []
is_a: GO:0046624 ! sphingolipid transporter activity
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0120017
name: ceramide transfer activity
namespace: molecular_function
alt_id: GO:0035620
def: "Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "ceramide carrier activity" EXACT []
synonym: "ceramide transporter activity" BROAD []
synonym: "intermembrane ceramide transfer activity" NARROW []
is_a: GO:0120016 ! sphingolipid transfer activity

[Term]
id: GO:0120019
name: phosphatidylcholine transfer activity
namespace: molecular_function
def: "Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "intermembrane phosphatidylcholine transfer activity" NARROW []
synonym: "phosphatidylcholine carrier activity" EXACT []
xref: Reactome:R-HSA-1483087 "PI is exchanged with PC by PITPNB"
xref: Reactome:R-HSA-1483211 "PC:PITPNB is transported from the Golgi membrane to the ER membrane"
xref: Reactome:R-HSA-1483219 "PC is exchanged with PI by PITPNB"
is_a: GO:0008525 ! phosphatidylcholine transporter activity
is_a: GO:0120014 ! phospholipid transfer activity

[Term]
id: GO:0120020
name: cholesterol transfer activity
namespace: molecular_function
alt_id: GO:0017127
def: "Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "cholesterol carrier activity" EXACT []
synonym: "cholesterol transporter activity" BROAD []
synonym: "intermembrane cholesterol transfer activity" NARROW []
xref: Reactome:R-HSA-1454928 "ABCG4 may mediate cholesterol efflux"
xref: Reactome:R-HSA-216723 "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane"
xref: Reactome:R-HSA-265443 "NPC1L1-mediated cholesterol uptake"
xref: Reactome:R-HSA-265545 "NPC1L1-mediated phytosterol uptake"
xref: Reactome:R-HSA-266082 "ABCG1-mediated transport of intracellular cholesterol to the cell surface"
xref: Reactome:R-HSA-5682111 "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane"
xref: Reactome:R-HSA-8951850 "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane"
is_a: GO:0120015 ! sterol transfer activity

[Term]
id: GO:0120021
name: oxysterol transfer activity
namespace: molecular_function
def: "Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
synonym: "intermembrane oxysterol transfer activity" NARROW []
synonym: "oxysterol carrier activity" EXACT []
is_a: GO:0120015 ! sterol transfer activity

[Term]
id: GO:0120022
name: glucagon family peptide binding
namespace: molecular_function
alt_id: GO:0120024
def: "Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP)." [PMID:17715056]
synonym: "glucagon binding" NARROW []
synonym: "glucagon-like peptide binding" NARROW []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0120023
name: somatostatin binding
namespace: molecular_function
def: "Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin." [GOC:cvs, PMID:20472043]
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0120025
name: plasma membrane bounded cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0120026
name: host cell uropod
namespace: cellular_component
def: "A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [PMID:24965475]
synonym: "host cell uropodium" EXACT []
is_a: GO:0044157 ! host cell projection

[Term]
id: GO:0120027
name: obsolete regulation of osmosensory signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of osmosensory signaling pathway." [GOC:vw]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0120028
name: obsolete negative regulation of osmosensory signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling pathway." [GOC:vw]
comment: This term was obsoleted because it is an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0120029
name: proton export across plasma membrane
namespace: biological_process
def: "The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:9762918]
synonym: "hydrogen ion export across plasma membrane" EXACT []
synonym: "hydrogen ion export from cell" BROAD []
synonym: "proton export from cell" BROAD []
is_a: GO:0140115 ! export across plasma membrane
is_a: GO:1902600 ! proton transmembrane transport

[Term]
id: GO:0120030
name: positive regulation of cilium beat frequency involved in ciliary motility
namespace: biological_process
def: "Any process that activates or increases the frequency of cilium beating involved in ciliary motility." [PMID:28035044]
is_a: GO:0060296 ! regulation of cilium beat frequency involved in ciliary motility

[Term]
id: GO:0120031
name: plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]
synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0120032
name: regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0060491 ! regulation of cell projection assembly
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
relationship: regulates GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0120033
name: negative regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0120034
name: positive regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly

[Term]
id: GO:0120035
name: regulation of plasma membrane bounded cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc]
is_a: GO:0031344 ! regulation of cell projection organization
relationship: regulates GO:0120036 ! plasma membrane bounded cell projection organization

[Term]
id: GO:0120036
name: plasma membrane bounded cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0120038
name: obsolete plasma membrane bounded cell projection part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a plasma membrane bounded cell projection, a prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc]
is_obsolete: true
consider: GO:0120025

[Term]
id: GO:0120039
name: plasma membrane bounded cell projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc]
is_a: GO:0048858 ! cell projection morphogenesis

[Term]
id: GO:0120040
name: regulation of macrophage proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: regulates GO:0061517 ! macrophage proliferation

[Term]
id: GO:0120041
name: positive regulation of macrophage proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0120040 ! regulation of macrophage proliferation
relationship: positively_regulates GO:0061517 ! macrophage proliferation

[Term]
id: GO:0120042
name: negative regulation of macrophage proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0120040 ! regulation of macrophage proliferation
relationship: negatively_regulates GO:0061517 ! macrophage proliferation

[Term]
id: GO:0120043
name: stereocilium shaft
namespace: cellular_component
def: "The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle." [GOC:krc, PMID:20170899]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0120044
name: stereocilium base
namespace: cellular_component
def: "The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium." [GOC:krc, PMID:20170899]
synonym: "stereocilium taper" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0120045
name: stereocilium maintenance
namespace: biological_process
def: "The organization process that preserves a stereocilium in a stable functional or structural state." [GOC:krc, PMID:27693694]
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0060122 ! inner ear receptor cell stereocilium organization

[Term]
id: GO:0120046
name: regulation of protein localization to medial cortical node
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node." [PMID:19474789]
is_a: GO:0106011 ! regulation of protein localization to medial cortex
relationship: regulates GO:1902577 ! protein localization to medial cortical node

[Term]
id: GO:0120047
name: positive regulation of protein localization to medial cortical node
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node." [PMID:19474789]
is_a: GO:0106012 ! positive regulation of protein localization to medial cortex
is_a: GO:0120046 ! regulation of protein localization to medial cortical node
relationship: positively_regulates GO:1902577 ! protein localization to medial cortical node

[Term]
id: GO:0120048
name: U6 snRNA (adenine-(43)-N(6))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine in U6 snRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine." [PMID:28525753, PMID:32266935, RHEA:52808]
xref: EC:2.1.1.346
xref: MetaCyc:RXN-18779
xref: RHEA:52808
is_a: GO:0106346 ! snRNA methyltransferase activity

[Term]
id: GO:0120049
name: snRNA (adenine-N6)-methylation
namespace: biological_process
def: "The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule." [PMID:28525753]
is_a: GO:0040031 ! snRNA modification

[Term]
id: GO:0120053
name: ribitol beta-1,4-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R." [PMID:27733679]
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0120054
name: intestinal motility
namespace: biological_process
def: "Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth)." [GOC:sl, PMID:15890336]
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0120055
name: small intestinal transit
namespace: biological_process
def: "Migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336]
synonym: "small bowel transit" EXACT []
synonym: "small intestine transit" EXACT []
is_a: GO:0120054 ! intestinal motility

[Term]
id: GO:0120056
name: large intestinal transit
namespace: biological_process
def: "Migration of ingested material along the length of the large intestine." [GOC:sl, PMID:28157109]
synonym: "colon transit" EXACT []
synonym: "colonic transit" EXACT []
synonym: "large bowel transit" EXACT []
synonym: "large intestine transit" EXACT []
is_a: GO:0120054 ! intestinal motility

[Term]
id: GO:0120057
name: regulation of small intestinal transit
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336]
synonym: "regulation of small bowel transit" EXACT []
synonym: "regulation of small intestine transit" EXACT []
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0120055 ! small intestinal transit

[Term]
id: GO:0120058
name: positive regulation of small intestinal transit
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336]
synonym: "positive regulation of small bowel transit" EXACT []
synonym: "positive regulation of small intestine transit" EXACT []
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0120057 ! regulation of small intestinal transit
relationship: positively_regulates GO:0120055 ! small intestinal transit

[Term]
id: GO:0120059
name: negative regulation of small intestinal transit
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336]
synonym: "negative regulation of small bowel transit" EXACT []
synonym: "negative regulation of small intestine transit" EXACT []
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:0120057 ! regulation of small intestinal transit
relationship: negatively_regulates GO:0120055 ! small intestinal transit

[Term]
id: GO:0120060
name: regulation of gastric emptying
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336]
synonym: "regulation of small bowel emptying" EXACT []
synonym: "regulation of small intestine emptying" EXACT []
is_a: GO:1905333 ! regulation of gastric motility
relationship: regulates GO:0035483 ! gastric emptying

[Term]
id: GO:0120061
name: negative regulation of gastric emptying
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336]
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:0120060 ! regulation of gastric emptying
relationship: negatively_regulates GO:0035483 ! gastric emptying

[Term]
id: GO:0120062
name: positive regulation of gastric emptying
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336]
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0120060 ! regulation of gastric emptying
relationship: positively_regulates GO:0035483 ! gastric emptying

[Term]
id: GO:0120063
name: stomach smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs throughout the length of the stomach." [GOC:sl, PMID:15890336]
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0120064
name: stomach pylorus smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the most distal part of the stomach." [GOC:sl, PMID:15890336]
is_a: GO:0014828 ! distal stomach smooth muscle contraction

[Term]
id: GO:0120065
name: pyloric antrum smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the widest part of the pylorus that is continuous with the body of the stomach." [GOC:sl, PMID:15890336]
synonym: "antrum smooth muscle contraction" EXACT []
is_a: GO:0120064 ! stomach pylorus smooth muscle contraction

[Term]
id: GO:0120066
name: pyloric canal smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter." [GOC:sl, PMID:15890336]
is_a: GO:0120064 ! stomach pylorus smooth muscle contraction

[Term]
id: GO:0120067
name: pyloric sphincter smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum." [GOC:sl, PMID:15890336]
is_a: GO:0120064 ! stomach pylorus smooth muscle contraction

[Term]
id: GO:0120068
name: regulation of stomach fundus smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
relationship: regulates GO:0014825 ! stomach fundus smooth muscle contraction

[Term]
id: GO:0120069
name: positive regulation of stomach fundus smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336]
is_a: GO:0120068 ! regulation of stomach fundus smooth muscle contraction
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
relationship: positively_regulates GO:0014825 ! stomach fundus smooth muscle contraction

[Term]
id: GO:0120070
name: negative regulation of stomach fundus smooth muscle contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336]
is_a: GO:0120068 ! regulation of stomach fundus smooth muscle contraction
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
relationship: negatively_regulates GO:0014825 ! stomach fundus smooth muscle contraction

[Term]
id: GO:0120071
name: regulation of pyloric antrum smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
relationship: regulates GO:0120065 ! pyloric antrum smooth muscle contraction

[Term]
id: GO:0120072
name: positive regulation of pyloric antrum smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336]
is_a: GO:0120071 ! regulation of pyloric antrum smooth muscle contraction
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
relationship: positively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction

[Term]
id: GO:0120073
name: negative regulation of pyloric antrum smooth muscle contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336]
is_a: GO:0120071 ! regulation of pyloric antrum smooth muscle contraction
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
relationship: negatively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction

[Term]
id: GO:0120074
name: regulation of endocardial cushion cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:1905207 ! regulation of cardiocyte differentiation
relationship: regulates GO:0061443 ! endocardial cushion cell differentiation

[Term]
id: GO:0120075
name: positive regulation of endocardial cushion cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0120074 ! regulation of endocardial cushion cell differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
relationship: positively_regulates GO:0061443 ! endocardial cushion cell differentiation

[Term]
id: GO:0120076
name: negative regulation of endocardial cushion cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocardial cushion cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0120074 ! regulation of endocardial cushion cell differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
relationship: negatively_regulates GO:0061443 ! endocardial cushion cell differentiation

[Term]
id: GO:0120077
name: angiogenic sprout fusion
namespace: biological_process
def: "The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis." [GOC:cvs, PMID:28264837]
synonym: "blood vessel anastomosis" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0120078
name: cell adhesion involved in sprouting angiogenesis
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a blood vessel network." [GOC:cvs, PMID:28264837]
synonym: "cell adhesion involved in blood vessel anastomosis" EXACT []
synonym: "cell adhesion involved in vascular anastomosis" RELATED []
is_a: GO:0007155 ! cell adhesion
relationship: part_of GO:0120077 ! angiogenic sprout fusion

[Term]
id: GO:0120079
name: obsolete regulation of microfilament motor activity
namespace: biological_process
alt_id: GO:1904621
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471, PMID:8621557]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of actin filament motor activity" EXACT []
synonym: "regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie]
synonym: "regulation of actin-dependent ATPase activity" RELATED []
synonym: "regulation of actin-filament motor activity" EXACT []
synonym: "regulation of muscle motor activity" NARROW []
synonym: "regulation of myosin ATPase activity" RELATED []
is_obsolete: true
consider: GO:0140659

[Term]
id: GO:0120080
name: obsolete negative regulation of microfilament motor activity
namespace: biological_process
alt_id: GO:1904622
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471, PMID:8621557]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of actin-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of actin-dependent ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin filament motor activity" EXACT []
synonym: "negative regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of actin-dependent ATPase activity" RELATED []
synonym: "negative regulation of actin-filament motor activity" EXACT []
synonym: "negative regulation of muscle motor activity" NARROW []
synonym: "negative regulation of myosin ATPase activity" RELATED []
is_obsolete: true
consider: GO:0140661

[Term]
id: GO:0120081
name: obsolete positive regulation of microfilament motor activity
namespace: biological_process
alt_id: GO:1904623
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471, PMID:8621557]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of actin-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of actin-dependent ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin filament motor activity" EXACT []
synonym: "positive regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of actin-dependent ATPase activity" RELATED []
synonym: "positive regulation of actin-filament motor activity" EXACT []
synonym: "positive regulation of muscle motor activity" NARROW []
synonym: "positive regulation of myosin ATPase activity" BROAD []
synonym: "upregulation of actin-dependent ATPase activity" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0140660

[Term]
id: GO:0120082
name: smooth endoplasmic reticulum cisterna
namespace: cellular_component
def: "A subcompartment of the smooth endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity." [GOC:sl, PMID:12112448]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum
relationship: part_of GO:0071781 ! endoplasmic reticulum cisternal network

[Term]
id: GO:0120083
name: rough endoplasmic reticulum cisterna
namespace: cellular_component
def: "A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity." [GOC:sl, PMID:12112448]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005791 ! rough endoplasmic reticulum
relationship: part_of GO:0071781 ! endoplasmic reticulum cisternal network

[Term]
id: GO:0120084
name: endothelial tip cell filopodium assembly
namespace: biological_process
def: "The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout." [GOC:cvs, PMID:28264837]
is_a: GO:0046847 ! filopodium assembly

[Term]
id: GO:0120085
name: obsolete transposon integration involved in RNA-mediated transposition
namespace: biological_process
def: "OBSOLETE. Any transposon integration that contributes to a process of RNA-mediated transposition." [GOC:mah, PMID:26358720]
comment: This term was obsoleted because it represents a readout.
synonym: "retrotransposon integration" EXACT []
is_obsolete: true
consider: GO:0032197

[Term]
id: GO:0120086
name: (3S)-(+)-asterisca-2(9),6-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene." [PMID:27862766]
synonym: "asterisca-2(9),6-diene synthase activity" BROAD []
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0120091
name: jasmonic acid hydrolase
namespace: molecular_function
def: "Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid." [PMID:28559313, PMID:28760569]
synonym: "2-oxoglutarate dioxygenase" BROAD []
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0120092
name: crotonyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." [PMID:28803779]
xref: RHEA:45584
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0120093
name: regulation of peptidyl-lysine crotonylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein." [PMID:28803779]
subset: gocheck_obsoletion_candidate
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0140066 ! peptidyl-lysine crotonylation

[Term]
id: GO:0120094
name: negative regulation of peptidyl-lysine crotonylation
namespace: biological_process
def: "Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein." [PMID:28803779]
subset: gocheck_obsoletion_candidate
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0120093 ! regulation of peptidyl-lysine crotonylation
relationship: negatively_regulates GO:0140066 ! peptidyl-lysine crotonylation

[Term]
id: GO:0120095
name: vacuole-isolation membrane contact site
namespace: cellular_component
def: "An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome." [PMID:23549786]
synonym: "vacuole-IM contact site" EXACT []
synonym: "vacuole-phagophore contact site" EXACT []
synonym: "VICS" RELATED []
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0120097
name: glycosylphosphatidylinositol-mannosyltransferase II complex
namespace: cellular_component
def: "A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p." [GOC:bhm, PMID:17615295]
synonym: "GPI-MT-I complex" RELATED []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:0120098
name: procentriole
namespace: cellular_component
def: "A cellular structure that is the site of a developing centriole, which will become a microtubule organizing center. During the canonical pathway of centriole duplication that occurs during the cell division cycle, procentrioles grow at the proximal ends of both mother and daughter centrioles. In the newly divided cells, the original mother and daughter centrioles become mother centrioles while the procentrioles become the new daughter centrioles. Procentrioles can also arise from de novo pathways that occur in multiciliated cells. In ciliated epithelial cells, numerous procentrioles arise form electron dense material referred to as fibrous granules and deuterosomes. The pathway of procentriole formation in multiciliated protists appears to be similar to that in mammalian multiciliated epithelium. In sperm of primitive land plants, multiple procentrioles are formed from a blepharoplast giving rise to multicilated sperm cells." [GOC:bhm, GOC:krc, PMID:18620859, PMID:21289083, PMID:25047614]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0120099
name: procentriole replication complex
namespace: cellular_component
def: "A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates." [GOC:bhm, PMID:17576815, PMID:18207742, PMID:21059844, PMID:22020124, PMID:24997597]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0120100
name: bacterial-type flagellum motor
namespace: cellular_component
def: "A transmembrane complex embedded in the cytoplasmic membrane which is the motor force, or torque, generator of the bacterial-type flagellum. The motor consists of a membrane-anchored rotor complex surrounded by one or more stator complexes in the cytoplasmic membrane. The stator consists of a hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. Examples are the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. The rotor complex consists of a membrane-anchored ring and the motor switch complex, which controls the direction of flagellar rotation." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0120101
name: bacterial-type flagellum stator complex
namespace: cellular_component
def: "A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species." [GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856]
synonym: "bacterial-type flagellum motor force generator complex" EXACT [PMID:24697492]
synonym: "bacterial-type flagellum torque generator complex" EXACT [DOI:10.1002/9780470015902.a0000744.pub4]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0120100 ! bacterial-type flagellum motor

[Term]
id: GO:0120102
name: bacterial-type flagellum secretion apparatus
namespace: cellular_component
def: "A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856]
synonym: "bacterial-type flagellum export apparatus" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0120103
name: centriolar subdistal appendage
namespace: cellular_component
def: "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092]
synonym: "subdistal appendage of basal body" EXACT [GOC:krc]
synonym: "subdistal appendage of centriole" EXACT [GOC:krc]
synonym: "subdistal appendage of mother centriole" EXACT [GOC:krc]
is_a: GO:0140535 ! intracellular protein-containing complex
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0120104
name: mitotic actomyosin contractile ring, proximal layer
namespace: cellular_component
def: "The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located." [GOC:krc, GOC:vw, PMID:28914606]
synonym: "actomyosin contractile ring, proximal layer" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring

[Term]
id: GO:0120105
name: mitotic actomyosin contractile ring, intermediate layer
namespace: cellular_component
def: "The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer." [GOC:krc, GOC:vw, PMID:28914606]
synonym: "actomyosin contractile ring, intermediate layer" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring

[Term]
id: GO:0120106
name: mitotic actomyosin contractile ring, distal actin filament layer
namespace: cellular_component
def: "The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to." [GOC:krc, GOC:vw, PMID:28914606]
synonym: "actomyosin contractile ring, distal actin filament layer" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring

[Term]
id: GO:0120107
name: bacterial-type flagellum rotor complex
namespace: cellular_component
def: "The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation." [GOC:cilia, PMID:10572114, PMID:12624192, PMID:25251856]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0120100 ! bacterial-type flagellum motor

[Term]
id: GO:0120108
name: DNA-3'-diphospho-5'-guanosine diphosphatase
namespace: molecular_function
def: "Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP." [PMID:26007660, RHEA:52140]
synonym: "DNA-3'pp5'G guanylate hydrolase" EXACT []
xref: EC:3.6.1.72
xref: RHEA:52140
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0120109
name: mitotic telomere clustering and tethering at nuclear periphery
namespace: biological_process
def: "The process in which the telomeres are gathered together to a small number of foci per chromosome (usually one per chromosome or fewer), and moved to and tethered at the nuclear periphery, as part of a mitotic cell cycle." [PMID:25778919]
is_a: GO:0034397 ! telomere localization

[Term]
id: GO:0120110
name: interphase mitotic telomere clustering
namespace: biological_process
def: "The process whereby the mitotic telomeres are gathered together during, or prior to, attachment to the nuclear envelope." [PMID:25778919]
comment: It is likely that both intra chromosome telomere clustering and inter-chromosome occur because a single focus is sometimes observed, although this has yet to be proven.
synonym: "mitotic telomere clustering during interphase" EXACT []
is_a: GO:0034397 ! telomere localization
relationship: part_of GO:0120109 ! mitotic telomere clustering and tethering at nuclear periphery

[Term]
id: GO:0120111
name: neuron projection cytoplasm
namespace: cellular_component
def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha]
is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0120112
name: UDP-glucose transmembrane transport into endoplasmic reticulum
namespace: biological_process
def: "The directed movement of UDP-glucose from cytosol to endoplasmic reticulum." [PMID:27587357]
is_a: GO:0015786 ! UDP-glucose transmembrane transport
is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport

[Term]
id: GO:0120113
name: cytoplasm to vacuole targeting by the NVT pathway
namespace: biological_process
def: "A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe." [PMID:26365378]
synonym: "protein localization by the Nbr1-mediated vacuolar targeting pathway" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole

[Term]
id: GO:0120114
name: Sm-like protein family complex
namespace: cellular_component
def: "A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles." [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0120115
name: Lsm2-8 complex
namespace: cellular_component
def: "A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23221597, PMID:27627834, PMID:28768202]
is_a: GO:0120114 ! Sm-like protein family complex

[Term]
id: GO:0120116
name: glucagon processing
namespace: biological_process
def: "The formation of mature glucagon by proteolysis of the precursor proglucagon." [PMID:28719828]
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0120117
name: T cell meandering migration
namespace: biological_process
def: "The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs)." [GOC:add, GOC:krc, PMID:25083865]
synonym: "lymph node surveillance" RELATED []
synonym: "T cell meandering search" EXACT []
is_a: GO:0072678 ! T cell migration

[Term]
id: GO:0120118
name: flagella connector
namespace: cellular_component
def: "A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum." [PMID:11641501, PMID:15075226, PMID:16954145, PMID:26820516]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use.
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0120119
name: flagellum attachment zone
namespace: cellular_component
def: "A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species." [PMID:10361731, PMID:16414276, PMID:17945531, PMID:20541452, PMID:25972344, PMID:2606941, PMID:26746239, PMID:26776656]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use.
synonym: "FAZ" RELATED []
is_a: GO:0070161 ! anchoring junction

[Term]
id: GO:0120120
name: bilobe structure
namespace: cellular_component
def: "A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone)." [PMID:22327007, PMID:22445359, PMID:26540076]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use.
synonym: "kinetoplastid flagellar hook complex" EXACT [PMID:26540076]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0120121
name: tripartite attachment complex
namespace: cellular_component
def: "A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body." [PMID:12802053, PMID:18059470, PMID:24821793, PMID:27168148]
synonym: "TAC" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0120122
name: prolactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals." [PMID:11015620]
synonym: "prolactin metabolism" EXACT []
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0120123
name: ubiquitin activating enzyme complex
namespace: cellular_component
def: "A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:lnp, PMID:9545234]
synonym: "E1 complex" EXACT [GOC:lnp]
synonym: "E1 ubiquitin-activating enzyme" RELATED [GOC:lnp]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0120124
name: membrane fusion priming complex
namespace: cellular_component
def: "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes." [GOC:lnp, PMID:9015301]
synonym: "GATE-16 complex" EXACT []
synonym: "LMA1 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0120125
name: PNGase complex
namespace: cellular_component
def: "A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [GOC:lnp, PMID:15964983, PMID:16249333]
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:0120126
name: response to copper ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion." [GOC:sl, PMID:24024382]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0120127
name: response to zinc ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion." [GOC:sl, PMID:24024381]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0120132
name: positive regulation of apoptotic process in bone marrow cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27908889]
synonym: "activation of apoptosis in bone marrow" NARROW [GOC:krc]
synonym: "positive regulation of apoptosis in bone marrow" NARROW [GO:krc]
synonym: "positive regulation of apoptotic process in bone marrow" EXACT []
synonym: "positive regulation of bone marrow cell apoptosis" EXACT [GOC:krc]
synonym: "positive regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:krc]
synonym: "positive regulation of killing of bone marrow cells" EXACT [GOC:krc]
synonym: "positive regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:krc]
synonym: "positive regulation of programmed cell death, bone marrow cells" EXACT [GOC:krc]
synonym: "up regulation of apoptosis in bone marrow" EXACT [GOC:krc]
synonym: "up-regulation of apoptosis in bone marrow" EXACT [GOC:krc]
synonym: "upregulation of apoptosis in bone marrow" EXACT [GOC:krc]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0071865 ! regulation of apoptotic process in bone marrow cell
relationship: positively_regulates GO:0071839 ! apoptotic process in bone marrow cell

[Term]
id: GO:0120133
name: negative regulation of actin cortical patch assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches." [PMID:19962315]
synonym: "down regulation of actin cortical patch assembly" EXACT []
synonym: "down-regulation of actin cortical patch assembly" EXACT []
synonym: "downregulation of actin cortical patch assembly" EXACT []
synonym: "inhibition of actin cortical patch assembly" NARROW []
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0000147 ! actin cortical patch assembly

[Term]
id: GO:0120134
name: proximal portion of axoneme
namespace: cellular_component
def: "The portion of the axoneme that is close to the base of the cilium." [GOC:krc]
synonym: "proximal part of axoneme" EXACT [GOC:krc]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0120135
name: distal portion of axoneme
namespace: cellular_component
def: "The portion of the axoneme that is close to the tip of the cilium." [GOC:krc]
synonym: "distal part of axoneme" EXACT [GOC:krc]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0120136
name: dUMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dUMP = ADP + dUDP." [PMID:3010881, RHEA:30655]
synonym: "ATP:dUMP phosphotransferase activity" EXACT []
synonym: "deoxyuridine monophosphate kinase activity" EXACT []
synonym: "dUMP-kinase activity" EXACT []
xref: RHEA:30655
is_a: GO:0009041 ! UMP/dUMP kinase activity

[Term]
id: GO:0120137
name: obsolete positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0120138
name: regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615]
subset: gocheck_obsoletion_candidate
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0120139
name: obsolete positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0120140
name: obsolete negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0120141
name: regulation of ecdysone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor signaling pathway." [GOC:ha, PMID:23072462]
synonym: "regulation of ecdysone receptor-mediated signaling pathway" EXACT []
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:1905957 ! regulation of cellular response to alcohol
relationship: regulates GO:0035076 ! ecdysone receptor signaling pathway

[Term]
id: GO:0120142
name: positive regulation of ecdysone receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of any ecdysone receptor signaling pathway." [GOC:ha, PMID:23072462]
synonym: "positive regulation of ecdysone receptor-mediated signaling pathway" EXACT []
is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0120141 ! regulation of ecdysone receptor signaling pathway
relationship: positively_regulates GO:0035076 ! ecdysone receptor signaling pathway

[Term]
id: GO:0120143
name: negative regulation of ecdysone receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor signaling pathway." [GOC:ha, PMID:23072462]
synonym: "negative regulation of ecdysone receptor-mediated signaling pathway" EXACT []
is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0120141 ! regulation of ecdysone receptor signaling pathway
is_a: GO:1905958 ! negative regulation of cellular response to alcohol
relationship: negatively_regulates GO:0035076 ! ecdysone receptor signaling pathway

[Term]
id: GO:0120145
name: protein localization to basal ectoplasmic specialization
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization." [PMID:22872576]
synonym: "protein localisation in basal ectoplasmic specialization" EXACT [GOC:krc]
synonym: "protein localisation to basal ectoplasmic specialization" EXACT [GOC:krc]
synonym: "protein localization in basal ectoplasmic specialization" EXACT [GOC:krc]
is_a: GO:0150105 ! protein localization to cell-cell junction

[Term]
id: GO:0120146
name: sulfatide binding
namespace: molecular_function
def: "Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group." [GOC:krc, PMID:21525289, PMID:22619219, PMID:22977233, PMID:23574804, PMID:29497057, PMID:3549017, Wikipedia:Sulfatide]
synonym: "3-O-sulfogalactosylceramide binding" EXACT []
synonym: "SM4 binding" EXACT []
synonym: "sulfated galactocerebroside binding" EXACT []
is_a: GO:0051861 ! glycolipid binding

[Term]
id: GO:0120147
name: formylglycine-generating oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O." [EC:1.8.3.7, RHEA:51152]
xref: EC:1.8.3.7
xref: MetaCyc:RXN-16226
xref: RHEA:51152
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0120148
name: host cell centrosome
namespace: cellular_component
def: "A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [ISBN:0198547684]
synonym: "host centrosome" EXACT []
is_a: GO:0044163 ! host cytoskeleton

[Term]
id: GO:0120149
name: host cell peroxisome
namespace: cellular_component
def: "A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [PMID:9302272]
synonym: "host peroxisome" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0120150
name: obsolete regulation of mitotic actomyosin contractile ring disassembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring disassembly." [PMID:19109423]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
is_obsolete: true
replaced_by: GO:1903471

[Term]
id: GO:0120151
name: obsolete positive regulation of mitotic actomyosin contractile ring disassembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring disassembly." [PMID:19109423]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
is_obsolete: true
replaced_by: GO:1903473

[Term]
id: GO:0120152
name: calcium-dependent outer dynein arm binding
namespace: molecular_function
def: "Binding to an outer dynein arm in the presence of calcium." [GOC:krc, PMID:18620543]
is_a: GO:0048306 ! calcium-dependent protein binding

[Term]
id: GO:0120153
name: calcium-dependent carbohydrate binding
namespace: molecular_function
def: "Binding to a carbohydrate in the presence of calcium." [PMID:25912189]
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0120154
name: negative regulation of ERBB4 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway." [PMID:15219672]
is_a: GO:1901185 ! negative regulation of ERBB signaling pathway
relationship: negatively_regulates GO:0038130 ! ERBB4 signaling pathway

[Term]
id: GO:0120155
name: MIH complex
namespace: cellular_component
def: "A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins." [GOC:rn, PMID:24413167, PMID:24895401]
synonym: "Mlc1p-Iqg1p-Hof1p complex" EXACT [GOC:rn]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0120157
name: PAR polarity complex
namespace: cellular_component
def: "A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC." [GOC:lnp, PMID:11113154, PMID:18005931, PMID:22500799, PMID:28682236]
comment: "This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.
synonym: "apical polarity complex" EXACT [GOC:lnp]
synonym: "BEM1-CDC24-CLA4 complex" NARROW []
synonym: "Cdc42p GEF-PAK complex" NARROW []
synonym: "PAR3-PAR6-atypical PKC" NARROW [GOC:lnp]
synonym: "PAR3/PAR6/aPKC" NARROW [GOC:lnp]
synonym: "PAR6-PAR3-aPKC complex" NARROW [PMID:18005931]
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0120158
name: positive regulation of collagen catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb]
synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
relationship: positively_regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0120159
name: rRNA pseudouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a uridine in rRNA = a pseudouridine in rRNA. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:28432181, RHEA:54568]
xref: RHEA:54568
is_a: GO:0009982 ! pseudouridine synthase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0120160
name: intraciliary transport particle A binding
namespace: molecular_function
def: "Binding to an intraciliary transport particle A (IFT A) complex." [PMID:20889716]
synonym: "IFT A complex binding" RELATED []
synonym: "intraciliary transport complex A binding" EXACT []
synonym: "intraflagellar transport complex A binding" EXACT []
synonym: "intraflagellar transport particle A binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0120161
name: regulation of cold-induced thermogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cold-induced thermogenesis." [PMID:27876809]
synonym: "regulation of CIT" RELATED []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0106106 ! cold-induced thermogenesis

[Term]
id: GO:0120162
name: positive regulation of cold-induced thermogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis." [PMID:27876809]
synonym: "positive regulation of CIT" RELATED []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0120161 ! regulation of cold-induced thermogenesis
relationship: positively_regulates GO:0106106 ! cold-induced thermogenesis

[Term]
id: GO:0120163
name: negative regulation of cold-induced thermogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis." [PMID:27876809]
synonym: "negative regulation of CIT" RELATED []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0120161 ! regulation of cold-induced thermogenesis
relationship: negatively_regulates GO:0106106 ! cold-induced thermogenesis

[Term]
id: GO:0120164
name: conidium germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination." [DOI:10.1128/9781555815523.ch10, PMID:10835388, PMID:11377860, PMID:17950638, PMID:18944978, PMID:25063657, PMID:27355215, PMID:9529886]
is_a: GO:0009847 ! spore germination

[Term]
id: GO:0120165
name: perithecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of a perithecium over time, from its formation to the mature structure. Peritheicum is a flask-shaped fruiting body of certain molds and ascomycetous fungi having a pore for the escape of spores. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck." [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:19547974, PMID:20739093, PMID:25311923]
is_a: GO:0030582 ! reproductive fruiting body development

[Term]
id: GO:0120166
name: protoperithecium formation
namespace: biological_process
def: "The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium." [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:20739093, PMID:25311923, PMID:4410944, PMID:6235211, PMID:6235212]
comment: Note that this term represents protoperithecium formation across homothallic and heterothallic species that do not have the same mechanism.
is_a: GO:0030582 ! reproductive fruiting body development

[Term]
id: GO:0120168
name: detection of hot stimulus involved in thermoception
namespace: biological_process
def: "The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception." [PMID:21335241]
synonym: "sensory detection of heat stimulus during thermoception" EXACT []
synonym: "sensory detection of hot stimulus during thermoception" EXACT []
synonym: "sensory transduction of heat stimulus during thermoception" EXACT []
synonym: "sensory transduction of hot stimulus during thermoception" EXACT []
synonym: "thermoception, sensory detection of heat stimulus" EXACT []
synonym: "thermoception, sensory detection of hot stimulus" EXACT []
synonym: "thermoception, sensory transduction of heat stimulus" EXACT []
synonym: "thermoception, sensory transduction of hot stimulus" EXACT []
is_a: GO:0050960 ! detection of temperature stimulus involved in thermoception
relationship: part_of GO:0062036 ! sensory perception of hot stimulus

[Term]
id: GO:0120169
name: detection of cold stimulus involved in thermoception
namespace: biological_process
def: "The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception." [PMID:21335241]
synonym: "sensory detection of cold stimulus during thermoception" EXACT []
synonym: "sensory transduction of cold stimulus during thermoception" EXACT []
synonym: "thermoception, sensory detection of cold stimulus" EXACT []
synonym: "thermoception, sensory transduction of cold stimulus" EXACT []
is_a: GO:0050960 ! detection of temperature stimulus involved in thermoception
relationship: part_of GO:0062035 ! sensory perception of cold stimulus

[Term]
id: GO:0120170
name: intraciliary transport particle B binding
namespace: molecular_function
def: "Binding to an intraciliary transport particle B (IFT B) complex." [PMID:20889716]
synonym: "IFT B complex binding" RELATED []
synonym: "intraciliary transport complex B binding" EXACT []
synonym: "intraflagellar transport complex B binding" EXACT []
synonym: "intraflagellar transport particle B binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0120171
name: Cdc24p-Far1p-Gbetagamma complex
namespace: cellular_component
def: "A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit)." [PMID:10087263]
synonym: "CDC24-FAR1-BG complex" EXACT [GOC:bm]
synonym: "CDC24-FAR1-Gbetagamma complex" EXACT [GOC:bm]
synonym: "Cdc24p-Far1p-BG complex" EXACT [GOC:rn, PMID:10087263]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0120172
name: obsolete positive regulation of actin filament bundle convergence involved in mitotic contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly." [GOC:vw, PMID:24798735]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0120173
name: obsolete regulation of actin filament bundle convergence involved in mitotic contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly." [GOC:vw, PMID:24798735]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:0120174
name: stress-induced homeostatically regulated protein degradation pathway
namespace: biological_process
def: "A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway." [GOC:rl, GOC:rn, PMID:29861160]
comment: Note, although the SHRED pathway may contain some components in common with ER-associated protein degradation (ERAD) pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10 do not appear to be involved, and as such these pathways are currently considered to be distinct. ERAD pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M) and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by subsequent substrate ubiquitination and proteosome-mediated degradation. In contrast the SHRED pathway, although inducible by stress, targets diverse ER membrane and cytosolic proteins as well as numerous other native proteins in the absence of stress. In the SHRED pathway an Nma111p serine protease-mediated cleavage results in the generation of a Roq1p fragment that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. SHRED is also considered to be distinct from the endoplasmic reticulum unfolded protein response (GO:0030968), a process by which ER stress activates the ER membrane protein Ire1p, resulting in splicing of the HAC1 mRNA, followed by Hac1p-mediated up-regulation of UPR genes. Induction of SHRED does not require IRE1 or HAC1, and as such is currently considered to be distinct.
synonym: "SHRED pathway" RELATED [GOC:rn]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0120175
name: regulation of torso signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0008293 ! torso signaling pathway

[Term]
id: GO:0120176
name: positive regulation of torso signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0120175 ! regulation of torso signaling pathway
relationship: positively_regulates GO:0008293 ! torso signaling pathway

[Term]
id: GO:0120177
name: negative regulation of torso signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0120175 ! regulation of torso signaling pathway
relationship: negatively_regulates GO:0008293 ! torso signaling pathway

[Term]
id: GO:0120178
name: steroid hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln]
is_a: GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0120179
name: adherens junction disassembly
namespace: biological_process
def: "The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, PMID:25490267]
is_a: GO:0034332 ! adherens junction organization
is_a: GO:0150147 ! cell-cell junction disassembly

[Term]
id: GO:0120180
name: cell-substrate junction disassembly
namespace: biological_process
def: "The disaggregation of a cell-substrate junction into its constituent components." [GOC:aruk, GOC:bc, PMID:25490267]
is_a: GO:0150115 ! cell-substrate junction organization
is_a: GO:0150146 ! cell junction disassembly

[Term]
id: GO:0120181
name: focal adhesion disassembly
namespace: biological_process
def: "The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity." [PMID:25490267]
is_a: GO:0120180 ! cell-substrate junction disassembly

[Term]
id: GO:0120182
name: regulation of focal adhesion disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components." [PMID:25490267]
is_a: GO:0150116 ! regulation of cell-substrate junction organization
relationship: regulates GO:0120181 ! focal adhesion disassembly

[Term]
id: GO:0120183
name: positive regulation of focal adhesion disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components." [PMID:25490267]
is_a: GO:0120182 ! regulation of focal adhesion disassembly
is_a: GO:0150117 ! positive regulation of cell-substrate junction organization
relationship: positively_regulates GO:0120181 ! focal adhesion disassembly

[Term]
id: GO:0120184
name: negative regulation of focal adhesion disassembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components." [PMID:25490267]
is_a: GO:0120182 ! regulation of focal adhesion disassembly
is_a: GO:0150118 ! negative regulation of cell-substrate junction organization
relationship: negatively_regulates GO:0120181 ! focal adhesion disassembly

[Term]
id: GO:0120185
name: MBF transcription complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex." [PMID:9303312]
synonym: "DSC1 transcription factor complex assembly" EXACT []
synonym: "MBF complex assembly" EXACT []
synonym: "Mlu1-box binding factor assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0120186
name: negative regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453]
synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905634 ! regulation of protein localization to chromatin
relationship: negatively_regulates GO:0071168 ! protein localization to chromatin

[Term]
id: GO:0120187
name: positive regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453]
synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905634 ! regulation of protein localization to chromatin
relationship: positively_regulates GO:0071168 ! protein localization to chromatin

[Term]
id: GO:0120188
name: regulation of bile acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0032782 ! bile acid secretion

[Term]
id: GO:0120189
name: positive regulation of bile acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0120188 ! regulation of bile acid secretion
relationship: positively_regulates GO:0032782 ! bile acid secretion

[Term]
id: GO:0120190
name: negative regulation of bile acid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0120188 ! regulation of bile acid secretion
relationship: negatively_regulates GO:0032782 ! bile acid secretion

[Term]
id: GO:0120191
name: negative regulation of termination of RNA polymerase II transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription." [GOC:krc, GOC:vw, PMID:29899453]
synonym: "down regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc]
synonym: "down regulation of RNA polymerase II transcription termination" EXACT [GOC:krc]
synonym: "down regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc]
synonym: "down regulation of termination of RNA polymerase II transcription" EXACT [GOC:krc]
synonym: "down regulation of transcription termination from Pol II promoter" EXACT [GOC:krc]
synonym: "down regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc]
synonym: "down-regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc]
synonym: "down-regulation of RNA polymerase II transcription termination" EXACT [GOC:krc]
synonym: "down-regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc]
synonym: "down-regulation of termination of RNA polymerase II transcription" EXACT [GOC:krc]
synonym: "down-regulation of transcription termination from Pol II promoter" EXACT [GOC:krc]
synonym: "down-regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc]
synonym: "downregulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc]
synonym: "downregulation of RNA polymerase II transcription termination" EXACT [GOC:krc]
synonym: "downregulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc]
synonym: "downregulation of termination of RNA polymerase II transcription" EXACT [GOC:krc]
synonym: "downregulation of transcription termination from Pol II promoter" EXACT [GOC:krc]
synonym: "downregulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc]
synonym: "negative regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc]
synonym: "negative regulation of RNA polymerase II transcription termination" EXACT [GOC:krc]
synonym: "negative regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc]
synonym: "negative regulation of transcription termination from Pol II promoter" EXACT [GOC:krc]
synonym: "negative regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc]
synonym: "repression of RNA 3'-end formation by RNA polymerase II" NARROW [GOC:krc]
synonym: "repression of RNA polymerase II transcription termination" NARROW [GOC:krc]
synonym: "repression of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc]
synonym: "repression of termination of RNA polymerase II transcription" NARROW [GOC:krc]
synonym: "repression of transcription termination from Pol II promoter" NARROW [GOC:krc]
synonym: "repression of transcription termination from RNA polymerase II promoter" NARROW [GOC:krc]
is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II
is_a: GO:0060567 ! negative regulation of termination of DNA-templated transcription
is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription
relationship: negatively_regulates GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:0120192
name: tight junction assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:rl]
synonym: "occluding cell junction assembly" EXACT [GOC:rl]
synonym: "occluding junction assembly" EXACT [GOC:rl]
is_a: GO:0007043 ! cell-cell junction assembly
is_a: GO:0120193 ! tight junction organization

[Term]
id: GO:0120193
name: tight junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:krc, GOC:rl]
synonym: "occluding cell junction organization" EXACT [GOC:rl]
synonym: "occluding junction organization" EXACT []
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0120194
name: regulation of anther dehiscence
namespace: biological_process
def: "Any process involved in the dehiscence of an anther to release the pollen grains contained within it." [GOC:lr, PMID:30911018]
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0009901 ! anther dehiscence

[Term]
id: GO:0120195
name: positive regulation of anther dehiscence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anther dehiscence." [GOC:lr, PMID:30911018]
is_a: GO:0120194 ! regulation of anther dehiscence
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0009901 ! anther dehiscence

[Term]
id: GO:0120196
name: negative regulation of anther dehiscence
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence." [GOC:lr, PMID:30911018]
is_a: GO:0120194 ! regulation of anther dehiscence
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0009901 ! anther dehiscence

[Term]
id: GO:0120197
name: mucociliary clearance
namespace: biological_process
def: "The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways." [GOC:krc, PMID:24119105, PMID:27864314]
synonym: "MCC" RELATED [PMID:24119105, PMID:27864314]
synonym: "MCT" RELATED [PMID:28289722]
synonym: "mucociliary transport" EXACT [PMID:28289722]
is_a: GO:0003016 ! respiratory system process
is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement

[Term]
id: GO:0120198
name: positive regulation of imaginal disc-derived wing size
namespace: biological_process
def: "Any process that increases the size of an imaginal disc-derived wing." [GOC:ha, PIMD:23485686]
is_a: GO:0044719 ! regulation of imaginal disc-derived wing size

[Term]
id: GO:0120199
name: cone photoreceptor outer segment
namespace: cellular_component
def: "The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]
is_a: GO:0001750 ! photoreceptor outer segment

[Term]
id: GO:0120200
name: rod photoreceptor outer segment
namespace: cellular_component
def: "The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]
is_a: GO:0001750 ! photoreceptor outer segment

[Term]
id: GO:0120201
name: cone photoreceptor disc membrane
namespace: cellular_component
def: "Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]
is_a: GO:0060170 ! ciliary membrane
is_a: GO:0097381 ! photoreceptor disc membrane

[Term]
id: GO:0120202
name: rod photoreceptor disc membrane
namespace: cellular_component
def: "Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0097381 ! photoreceptor disc membrane

[Term]
id: GO:0120203
name: rod photoreceptor disc lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a rod photoreceptor cell disc membrane." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]
is_a: GO:0043233 ! organelle lumen
relationship: part_of GO:0120200 ! rod photoreceptor outer segment

[Term]
id: GO:0120204
name: methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2." [PMID:31043749]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0120205
name: photoreceptor proximal connecting cilium
namespace: cellular_component
def: "The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR." [GOC:krc, PMID:29899041]
synonym: "PCC" RELATED [PMID:29899041]
synonym: "photoreceptor PCC" RELATED [PMID:29899041]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032391 ! photoreceptor connecting cilium

[Term]
id: GO:0120206
name: photoreceptor distal connecting cilium
namespace: cellular_component
def: "The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability." [GOC:krc, PMID:29899041]
synonym: "DCC" RELATED [PMID:29899041]
synonym: "photoreceptor DCC" RELATED [PMID:29899041]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0032391 ! photoreceptor connecting cilium

[Term]
id: GO:0120207
name: endocytosis, site selection
namespace: biological_process
def: "The process of selecting and or marking the position where endocytosis will occur." [GOC:vw, PMID:30044717]
is_a: GO:1990778 ! protein localization to cell periphery
relationship: part_of GO:0006897 ! endocytosis

[Term]
id: GO:0120208
name: telodendria
namespace: cellular_component
def: "Telodendria are projections that originate from the axon pedicle and form gap junctions with other neurons." [GOC:cvs, GOC:krc, PMID:11074451, PMID:11506430, PMID:14755521, PMID:1646866, PMID:20533354, PMID:29127712, PMID:451992, PMID:8390352]
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0120209
name: cone telodendria
namespace: cellular_component
def: "Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina." [GOC:cvs, GOC:krc, PMID:29127712]
is_a: GO:0120208 ! telodendria

[Term]
id: GO:0120210
name: rod telodendria
namespace: cellular_component
def: "Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina." [GOC:cvs, GOC:krc, PMID:14755521]
is_a: GO:0120208 ! telodendria

[Term]
id: GO:0120211
name: proacrosomal vesicle fusion
namespace: biological_process
def: "Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome." [GOC:krc, PMID:29991750]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0001675 ! acrosome assembly

[Term]
id: GO:0120212
name: sperm head-tail coupling apparatus
namespace: cellular_component
def: "A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head." [GOC:krc, PMID:24415959, PMID:30032984]
synonym: "head-tail coupling apparatus" EXACT [PMID:24415959, PMID:30032984]
synonym: "HTCA" RELATED [PMID:24415959]
synonym: "implantation fossa" RELATED []
synonym: "sperm connecting piece" RELATED []
synonym: "sperm neck" RELATED []
xref: MP:0009830
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0120213
name: regulation of histidine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histidine biosynthetic process." [GOC:krc]
synonym: "regulation of histidine anabolism" EXACT [GOC:krc]
synonym: "regulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "regulation of histidine formation" EXACT [GOC:krc]
synonym: "regulation of histidine synthesis" EXACT [GOC:krc]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0000105 ! L-histidine biosynthetic process

[Term]
id: GO:0120214
name: negative regulation of histidine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process." [GOC:krc]
synonym: "down regulation of histidine anabolism" EXACT [GOC:krc]
synonym: "down regulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "down regulation of histidine biosynthetic process" EXACT [GOC:krc]
synonym: "down regulation of histidine formation" EXACT [GOC:krc]
synonym: "down regulation of histidine synthesis" EXACT [GOC:krc]
synonym: "down-regulation of histidine anabolism" EXACT [GOC:krc]
synonym: "down-regulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "down-regulation of histidine biosynthetic process" EXACT [GOC:krc]
synonym: "down-regulation of histidine formation" EXACT [GOC:krc]
synonym: "down-regulation of histidine synthesis" EXACT [GOC:krc]
synonym: "downregulation of histidine anabolism" EXACT [GOC:krc]
synonym: "downregulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "downregulation of histidine biosynthetic process" EXACT [GOC:krc]
synonym: "downregulation of histidine formation" EXACT [GOC:krc]
synonym: "downregulation of histidine synthesis" EXACT [GOC:krc]
synonym: "inhibition of histidine anabolism" NARROW [GOC:krc]
synonym: "inhibition of histidine biosynthesis" NARROW [GOC:krc]
synonym: "inhibition of histidine biosynthetic process" NARROW [GOC:krc]
synonym: "inhibition of histidine formation" NARROW [GOC:krc]
synonym: "inhibition of histidine synthesis" NARROW [GOC:krc]
synonym: "negative regulation of histidine anabolism" EXACT [GOC:krc]
synonym: "negative regulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "negative regulation of histidine formation" EXACT [GOC:krc]
synonym: "negative regulation of histidine synthesis" EXACT [GOC:krc]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0120213 ! regulation of histidine biosynthetic process
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:0000105 ! L-histidine biosynthetic process

[Term]
id: GO:0120215
name: positive regulation of histidine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process." [GOC:krc]
synonym: "activation of histidine anabolism" NARROW [GOC:krc]
synonym: "activation of histidine biosynthesis" NARROW [GOC:krc]
synonym: "activation of histidine biosynthetic process" NARROW [GOC:krc]
synonym: "activation of histidine formation" NARROW [GOC:krc]
synonym: "activation of histidine synthesis" NARROW [GOC:krc]
synonym: "positive regulation of histidine anabolism" EXACT [GOC:krc]
synonym: "positive regulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "positive regulation of histidine formation" EXACT [GOC:krc]
synonym: "positive regulation of histidine synthesis" EXACT [GOC:krc]
synonym: "up regulation of histidine anabolism" EXACT [GOC:krc]
synonym: "up regulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "up regulation of histidine biosynthetic process" EXACT [GOC:krc]
synonym: "up regulation of histidine formation" EXACT [GOC:krc]
synonym: "up regulation of histidine synthesis" EXACT [GOC:krc]
synonym: "up-regulation of histidine anabolism" EXACT [GOC:krc]
synonym: "up-regulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "up-regulation of histidine biosynthetic process" EXACT [GOC:krc]
synonym: "up-regulation of histidine formation" EXACT [GOC:krc]
synonym: "up-regulation of histidine synthesis" EXACT [GOC:krc]
synonym: "upregulation of histidine anabolism" EXACT [GOC:krc]
synonym: "upregulation of histidine biosynthesis" EXACT [GOC:krc]
synonym: "upregulation of histidine biosynthetic process" EXACT [GOC:krc]
synonym: "upregulation of histidine formation" EXACT [GOC:krc]
synonym: "upregulation of histidine synthesis" EXACT [GOC:krc]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0120213 ! regulation of histidine biosynthetic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
relationship: positively_regulates GO:0000105 ! L-histidine biosynthetic process

[Term]
id: GO:0120216
name: matrilin complex
namespace: cellular_component
def: "A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer." [GOC:bhm, PMID:10367731, PMID:15075323, PMID:9699631]
synonym: "matrilin family complex" RELATED [GOC:bhm]
synonym: "matrilin-1 complex" NARROW [GOC:bhm]
synonym: "matrilin-2 complex" NARROW [GOC:bhm]
synonym: "matrilin-3 complex" NARROW [GOC:bhm]
synonym: "matrilin-4 complex" NARROW [GOC:bhm]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0120217
name: DNA gyrase complex
namespace: cellular_component
def: "A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB)." [GOC:bhm, GOC:krc, PMID:1657531, PMID:20675723, Wikipedia:DNA_gyrase]
synonym: "topoisomerase II complex" EXACT [GOC:bhm, GOC:krc, Wikipedia:DNA_gyrase]
is_a: GO:0009330 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

[Term]
id: GO:0120218
name: host interaction involved in quorum sensing
namespace: biological_process
def: "A quorum sensing process that is modulated by some interaction with a host cell or organism." [GOC:krc, GOC:mlg, PMID:11780122, PMID:16630813]
is_a: GO:0009372 ! quorum sensing

[Term]
id: GO:0120219
name: subapical part of cell
namespace: cellular_component
def: "The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina." [GOC:krc, PMID:29891944]
synonym: "subapical region of cell" EXACT [GOC:krc]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0120220
name: basal body patch
namespace: cellular_component
def: "The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster." [GOC:krc, PMID:20164345, PMID:20685736, PMID:29891944]
synonym: "centriolar patch" EXACT [GOC:krc, PMID:29891944]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0120221
name: maintenance of ciliary planar beating movement pattern
namespace: biological_process
def: "Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement." [GOC:krc, PMID:26506310]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
is_a: GO:0003352 ! regulation of cilium movement

[Term]
id: GO:0120222
name: regulation of blastocyst development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blastocyst development." [GOC:krc, PMID:29593216]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0001824 ! blastocyst development

[Term]
id: GO:0120223
name: larynx morphogenesis
namespace: biological_process
def: "The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282]
synonym: "laryngeal morphogenesis" EXACT [GOC:krc, PMID:28177282]
is_a: GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0120224 ! larynx development

[Term]
id: GO:0120224
name: larynx development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282]
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0120225
name: coenzyme A binding
namespace: molecular_function
def: "Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:krc, ISBN:0198547684]
synonym: "CoA binding" EXACT []
is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901265 ! nucleoside phosphate binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0120226
name: succinyl-CoA binding
namespace: molecular_function
def: "Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component." [GOC:krc]
synonym: "succinyl-coenzyme A binding" EXACT []
is_a: GO:0120227 ! acyl-CoA binding

[Term]
id: GO:0120227
name: acyl-CoA binding
namespace: molecular_function
def: "Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid." [GOC:krc]
synonym: "acyl binding" BROAD []
synonym: "acyl-coenzyme A binding" EXACT []
is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901265 ! nucleoside phosphate binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0120228
name: outer dynein arm docking complex
namespace: cellular_component
def: "A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules." [GOC:krc, PMID:15064350, PMID:24067530, PMID:25192045, PMID:27486780, PMID:8045937]
synonym: "ODA docking complex" RELATED [PMID:27486780]
synonym: "ODA-DC" RELATED [PMID:27486780]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0120229
name: protein localization to motile cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780]
synonym: "protein localization to nonmotile primary cilium" RELATED []
is_a: GO:0061512 ! protein localization to cilium

[Term]
id: GO:0120230
name: recombinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a recombinase." [GOC:mah, PMID:32414915]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0120231
name: DNA recombinase auxiliary factor complex
namespace: cellular_component
def: "A protein complex that binds to a recombinase and incrseases its activity." [PMID:32414915]
synonym: "DNA recombinase accessory factor complex" EXACT [PMID:32414915]
synonym: "DNA recombinase activator complex" EXACT [PMID:32414915]
is_a: GO:0150005 ! enzyme activator complex

[Term]
id: GO:0120232
name: prenyl-FMNH2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754]
synonym: "prenyl-FMNH2 anabolism" EXACT []
synonym: "prenyl-FMNH2 biosynthesis" EXACT []
synonym: "prenyl-FMNH2 formation" EXACT []
synonym: "prenyl-FMNH2 synthesis" EXACT []
synonym: "prenylated FMNH2 anabolism" EXACT []
synonym: "prenylated FMNH2 biosynthesis" EXACT []
synonym: "prenylated FMNH2 biosynthetic process" EXACT []
synonym: "prenylated FMNH2 formation" EXACT []
synonym: "prenylated FMNH2 synthesis" EXACT []
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process

[Term]
id: GO:0120233
name: prenyl-FMNH2 binding
namespace: molecular_function
def: "Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754]
synonym: "prenylated FMNH2 binding" EXACT []
is_a: GO:0032553 ! ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0120234
name: stereocilium coat
namespace: cellular_component
def: "A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle." [GOC:krc, ISBN:9781461268918, PMID:31444330, PMID:3583936]
synonym: "auditory hair cell glycocalyx" BROAD []
synonym: "stereocilium glycocalyx" EXACT []
is_a: GO:0030112 ! glycocalyx
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0120235
name: regulation of post-translational protein targeting to membrane, translocation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of posttranslational protein translocation through the ER membrane." [GOC:krc, GOC:rn, PMID:32513868]
synonym: "regulation of N-terminal signal peptide-independent translocation into the ER" NARROW [GOC:rn]
synonym: "regulation of posttranslational endoplasmic reticulum membrane protein translocation" EXACT [GOC:rn]
synonym: "regulation of posttranslational protein targeting to membrane, translocation" EXACT []
synonym: "regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation" NARROW [GOC:rn]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:0031204 ! post-translational protein targeting to membrane, translocation

[Term]
id: GO:0120236
name: negative regulation of post-translational protein targeting to membrane, translocation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane." [GOC:krc, GOC:rn, PMID:32513868]
synonym: "negative regulation of N-terminal signal peptide-independent translocation into the ER" NARROW [GOC:rn]
synonym: "negative regulation of posttranslational endoplasmic reticulum membrane protein translocation" EXACT [GOC:rn]
synonym: "negative regulation of posttranslational protein targeting to membrane, translocation" EXACT []
synonym: "negative regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation" NARROW [GOC:rn]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:0120235 ! regulation of post-translational protein targeting to membrane, translocation
relationship: negatively_regulates GO:0031204 ! post-translational protein targeting to membrane, translocation

[Term]
id: GO:0120237
name: terminal acetylenic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]
synonym: "terminal alkyne substituted compound anabolic process" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound anabolism" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound biosynthesis" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound biosynthetic process" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound synthesis" EXACT [GOC:krc]
is_a: GO:0120244 ! terminal acetylenic compound metabolic process
is_a: GO:0120247 ! acetylenic compound biosynthetic process

[Term]
id: GO:0120238
name: sperm glycocalyx
namespace: cellular_component
def: "The carbohydrate rich layer at the outermost periphery of a sperm cell." [GOC:krc]
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0120239
name: vascular endothelial glycocalyx
namespace: cellular_component
def: "The carbohydrate-rich layer lining the vascular endothelium connected to the endothelium through a variety of molecules, mainly proteoglycans and glycoproteins. These form a network in which soluble molecules, either plasma- or endothelium-derived, are incorporated." [GOC:krc, PMID:17256154]
synonym: "endothelial glycocalyx" EXACT []
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0120240
name: platelet glycocalyx
namespace: cellular_component
def: "The carbohydrate rich layer at the outermost periphery of a platelet." [GOC:krc, PMID:24967889]
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0120241
name: 2-iminobutanoate/2-iminopropanoate deaminase
namespace: molecular_function
def: "Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17." [EC:3.5.99.10]
comment: This enzyme, which has been found in all species and tissues examined, catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates (from EC:3.5.99.10).
synonym: "2-iminobutanoate deaminase" NARROW [EC:3.5.99.10]
synonym: "2-iminopropanoate deaminase" NARROW [EC:3.5.99.10]
synonym: "enamine/imine deaminase" BROAD [EC:3.5.99.10]
synonym: "imine intermediate deaminase activity" RELATED [] {comment="EC:3.5.99.10"}
xref: EC:3.5.99.10
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0120242
name: 2-iminobutanoate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)." [RHEA:39975]
synonym: "2-iminobutanoate/2-iminopropanoate deaminase" BROAD [EC:3.5.99.10]
xref: KEGG_REACTION:R11098
xref: MetaCyc:RXN-15123
xref: RHEA:39975
is_a: GO:0120241 ! 2-iminobutanoate/2-iminopropanoate deaminase

[Term]
id: GO:0120243
name: 2-iminopropanoate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate." [RHEA:40671]
synonym: "2-iminobutanoate/2-iminopropanoate deaminase" BROAD [EC:3.5.99.10]
xref: KEGG_REACTION:R11099
xref: MetaCyc:RXN-15127
xref: RHEA:40671
is_a: GO:0120241 ! 2-iminobutanoate/2-iminopropanoate deaminase

[Term]
id: GO:0120244
name: terminal acetylenic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a terminal acetylenic compound, involving a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]
synonym: "terminal alkyne substituted compound metabolic process" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound metabolism" EXACT [GOC:krc]
is_a: GO:0120246 ! acetylenic compound metabolic process

[Term]
id: GO:0120245
name: terminal acetylenic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]
synonym: "terminal alkyne substituted compound breakdown" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound catabolic process" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound catabolism" EXACT [GOC:krc]
synonym: "terminal alkyne substituted compound degradation" EXACT [GOC:krc]
is_a: GO:0120244 ! terminal acetylenic compound metabolic process
is_a: GO:0120248 ! acetylenic compound catabolic process

[Term]
id: GO:0120246
name: acetylenic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C)." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]
synonym: "alkyne substituted compound metabolic process" EXACT []
synonym: "alkyne substituted compound metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0120247
name: acetylenic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C)." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]
synonym: "alkyne substituted compound anabolic process" EXACT [GOC:krc]
synonym: "alkyne substituted compound anabolism" EXACT [GOC:krc]
synonym: "alkyne substituted compound biosynthesis" EXACT [GOC:krc]
synonym: "alkyne substituted compound biosynthetic process" EXACT [GOC:krc]
synonym: "alkyne substituted compound synthesis" EXACT [GOC:krc]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0120246 ! acetylenic compound metabolic process

[Term]
id: GO:0120248
name: acetylenic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C)." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]
synonym: "alkyne substituted compound breakdown" EXACT [GOC:krc]
synonym: "alkyne substituted compound catabolic process" EXACT [GOC:krc]
synonym: "alkyne substituted compound catabolism" EXACT [GOC:krc]
synonym: "alkyne substituted compound degradation" EXACT [GOC:krc]
is_a: GO:0009056 ! catabolic process
is_a: GO:0120246 ! acetylenic compound metabolic process

[Term]
id: GO:0120249
name: lateral wall of outer hair cell
namespace: cellular_component
def: "The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae." [GOC:krc, PMID:26352669, PMID:31920560, PMID:9412485]
synonym: "lateral wall of OHC" RELATED [GOC:krc]
synonym: "OHC lateral wall" RELATED [GOC:krc]
synonym: "outer hair cell lateral wall" EXACT [GOC:krc]
is_a: GO:0097574 ! lateral part of cell

[Term]
id: GO:0120250
name: fatty acid omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:krc, RHEA:39023]
synonym: "omega-hydroxylase activity" BROAD [EC:1.14.15.3]
xref: RHEA:39023
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0120251
name: hydrocarbon biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a hydrocarbon, a compound consisting of carbon and hydrogen only." [GOC:krc, Wikipedia:Hydrocarbon]
synonym: "hydrocarbon anabolism" EXACT [GOC:krc]
synonym: "hydrocarbon biosynthesis" EXACT [GOC:krc]
synonym: "hydrocarbon formation" EXACT [GOC:krc]
synonym: "hydrocarbon synthesis" EXACT [GOC:krc]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0120252
name: hydrocarbon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a hydrocarbon, a compound consisting of carbon and hydrogen only." [GOC:krc, Wikipedia:Hydrocarbon]
synonym: "hydrocarbon metabolism" EXACT [GOC:krc]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0120253
name: hydrocarbon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a hydrocarbon, a compound consisting of carbon and hydrogen only." [GOC:krc, Wikipedia:Hydrocarbon]
synonym: "hydrocarbon breakdown" EXACT [GOC:krc]
synonym: "hydrocarbon catabolism" EXACT [GOC:krc]
synonym: "hydrocarbon degradation" EXACT [GOC:krc]
is_a: GO:0009056 ! catabolic process
is_a: GO:0120252 ! hydrocarbon metabolic process

[Term]
id: GO:0120254
name: olefinic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]
synonym: "alkene substituted compound metabolic process" EXACT []
synonym: "alkene substituted compound metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0120255
name: olefinic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]
synonym: "alkene substituted compound anabolic process" EXACT [GOC:krc]
synonym: "alkene substituted compound anabolism" EXACT [GOC:krc]
synonym: "alkene substituted compound biosynthesis" EXACT [GOC:krc]
synonym: "alkene substituted compound biosynthetic process" EXACT [GOC:krc]
synonym: "alkene substituted compound synthesis" EXACT [GOC:krc]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0120256
name: olefinic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]
synonym: "alkene substituted compound breakdown" EXACT [GOC:krc]
synonym: "alkene substituted compound catabolic process" EXACT [GOC:krc]
synonym: "alkene substituted compound catabolism" EXACT [GOC:krc]
synonym: "alkene substituted compound degradation" EXACT [GOC:krc]
is_a: GO:0009056 ! catabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:0120257
name: peptidyl-threonine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-threonine." [GOC:krc, PMID:16728640, PMID:22802624]
subset: gocheck_obsoletion_candidate
is_a: GO:0006473 ! protein acetylation

[Term]
id: GO:0120258
name: peptidyl-threonine O-acetylation
namespace: biological_process
def: "The acetylation of peptidyl-threonine to form peptidyl-O-acetyl-L-threonine." [PMID:16728640, PMID:22802624, RESID:AA0423]
subset: gocheck_obsoletion_candidate
xref: RESID:AA0364
is_a: GO:0018210 ! peptidyl-threonine modification
is_a: GO:0120257 ! peptidyl-threonine acetylation

[Term]
id: GO:0120259
name: 7SK snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb." [PMID:18249148, PMID:28431135]
synonym: "snRNP 7SK" EXACT [GOC:krc]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0120260
name: ciliary microtubule quartet
namespace: cellular_component
def: "A set of four specialized microtubules that originates from the basal bodies and wraps around the ciliary pocket membrane, likely supporting its distinct flask shape." [DOI:10.5772/66859, GOC:ach, GOC:krc, PMID:19299460, PMID:32518185]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.
synonym: "ciliary MtQ" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0120261
name: regulation of heterochromatin organization
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or location of heterochromatin organization." [GOC:krc]
is_a: GO:1902275 ! regulation of chromatin organization
relationship: regulates GO:0070828 ! heterochromatin organization

[Term]
id: GO:0120262
name: negative regulation of heterochromatin organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization." [GOC:krc]
synonym: "down regulation of heterochromatin organization" EXACT []
synonym: "down-regulation of heterochromatin organization" EXACT []
synonym: "downregulation of heterochromatin organization" EXACT []
synonym: "inhibition of heterochromatin organization" NARROW []
is_a: GO:0120261 ! regulation of heterochromatin organization
is_a: GO:1905268 ! negative regulation of chromatin organization
relationship: negatively_regulates GO:0070828 ! heterochromatin organization

[Term]
id: GO:0120263
name: positive regulation of heterochromatin organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heterochromatin organization." [GOC:krc]
synonym: "activation of heterochromatin organization" NARROW []
synonym: "stimulation of heterochromatin organization" NARROW []
synonym: "up regulation of heterochromatin organization" EXACT []
synonym: "up-regulation of heterochromatin organization" EXACT []
synonym: "upregulation of heterochromatin organization" EXACT []
is_a: GO:0120261 ! regulation of heterochromatin organization
is_a: GO:1905269 ! positive regulation of chromatin organization
relationship: positively_regulates GO:0070828 ! heterochromatin organization

[Term]
id: GO:0120264
name: regulation of chromosome attachment to the nuclear envelope
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or location of chromosome attachment to the nuclear envelope." [GOC:krc]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0097240 ! chromosome attachment to the nuclear envelope

[Term]
id: GO:0120265
name: negative regulation of chromosome attachment to the nuclear envelope
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chromosome attachment to the nuclear envelope." [GOC:krc]
synonym: "down regulation of chromosome attachment to the nuclear envelope" EXACT []
synonym: "down-regulation of chromosome attachment to the nuclear envelope" EXACT []
synonym: "downregulation of chromosome attachment to the nuclear envelope" EXACT []
synonym: "inhibition of chromosome attachment to the nuclear envelope" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0120264 ! regulation of chromosome attachment to the nuclear envelope
relationship: negatively_regulates GO:0097240 ! chromosome attachment to the nuclear envelope

[Term]
id: GO:0120266
name: positive regulation of chromosome attachment to the nuclear envelope
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chromosome attachment to the nuclear envelope." [GOC:krc]
synonym: "activation of chromosome attachment to the nuclear envelope" NARROW []
synonym: "stimulation of chromosome attachment to the nuclear envelope" NARROW []
synonym: "up regulation of chromosome attachment to the nuclear envelope" EXACT []
synonym: "up-regulation of chromosome attachment to the nuclear envelope" EXACT []
synonym: "upregulation of chromosome attachment to the nuclear envelope" EXACT []
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0120264 ! regulation of chromosome attachment to the nuclear envelope
relationship: positively_regulates GO:0097240 ! chromosome attachment to the nuclear envelope

[Term]
id: GO:0120267
name: pellicular membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the pellicle, a structure enclosing some parasite cells such as certain apicomplexa and Euglenozoa. These membranes are associated with an infrastructure of microtubules, microfilaments, and other organelles." [GOC:ach, GOC:krc, PMID:18095354, PMID:30550896, PMID:6993644, PMID:7175771]
comment: This sub-domain of the plasma membrane excludes the ciliary and ciliary pocket membranes.
synonym: "pellicle membrane" EXACT []
synonym: "pellicular plasma membrane" EXACT []
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0120268
name: paraflagellar rod assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme." [GOC:ach, GOC:krc, PMID:23787017, PMID:32295845]
synonym: "paraflagellar rod biogenesis" EXACT []
synonym: "paraflagellar rod formation" EXACT []
synonym: "PFR assembly" RELATED []
is_a: GO:0044458 ! motile cilium assembly

[Term]
id: GO:0120269
name: ciliary centrin arm
namespace: cellular_component
def: "A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules." [GOC:ach, GOC:krc, PMID:26540076, PMID:31217284]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.
is_a: GO:0140535 ! intracellular protein-containing complex
relationship: part_of GO:0020016 ! ciliary pocket

[Term]
id: GO:0120270
name: regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [GOC:krc, PMID:24920274]
is_a: GO:0061013 ! regulation of mRNA catabolic process
relationship: regulates GO:0033621 ! nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

[Term]
id: GO:0120271
name: negative regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [GOC:krc, PMID:24920274]
is_a: GO:0120270 ! regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
is_a: GO:1902373 ! negative regulation of mRNA catabolic process
relationship: negatively_regulates GO:0033621 ! nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

[Term]
id: GO:0120272
name: positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [GOC:krc, PMID:24920274]
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:0120270 ! regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
relationship: positively_regulates GO:0033621 ! nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

[Term]
id: GO:0120273
name: ciliary centrin arm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a ciliary centrin arm, a rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules." [GOC:ach, GOC:krc, PMID:32675283]
synonym: "ciliary centrin arm formation" RELATED []
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0060271 ! cilium assembly

[Term]
id: GO:0120274
name: virus coreceptor activity
namespace: molecular_function
def: "Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:ha, GOC:krc, PMID:16051304]
subset: goslim_generic
synonym: "viral coreceptor activity" EXACT []
is_a: GO:0140272 ! exogenous protein binding

[Term]
id: GO:0120275
name: cerebral blood circulation
namespace: biological_process
def: "The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:krc, PMID:25397684]
synonym: "cerebrum blood circulation" EXACT []
synonym: "telencephelon blood circulation" EXACT []
is_a: GO:0008015 ! blood circulation

[Term]
id: GO:0120276
name: regulation of cerebral blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684]
synonym: "regulation of cerebrum blood circulation" EXACT []
synonym: "regulation of telencephalon blood circulation" EXACT []
is_a: GO:1903522 ! regulation of blood circulation
relationship: regulates GO:0120275 ! cerebral blood circulation

[Term]
id: GO:0120277
name: positive regulation of cerebral blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684]
synonym: "activation of cerebral blood circulation" NARROW []
synonym: "positive regulation of cerebrum blood circulation" EXACT []
synonym: "positive regulation of telencephalon blood circulation" EXACT []
synonym: "up regulation of cerebral blood circulation" EXACT []
synonym: "up-regulation of cerebral blood circulation" EXACT []
synonym: "upregulation of cerebral blood circulation" EXACT []
is_a: GO:0120276 ! regulation of cerebral blood circulation
is_a: GO:1903524 ! positive regulation of blood circulation
relationship: positively_regulates GO:0120275 ! cerebral blood circulation

[Term]
id: GO:0120278
name: negative regulation of cerebral blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684]
synonym: "down regulation of cerebral blood circulation" EXACT []
synonym: "down-regulation of cerebral blood circulation" EXACT []
synonym: "downregulation of cerebral blood circulation" EXACT []
synonym: "inhibition of cerebral blood circulation" NARROW []
synonym: "negative regulation of cerebrum blood circulation" EXACT []
synonym: "negative regulation of telencephalon blood circulation" EXACT []
is_a: GO:0120276 ! regulation of cerebral blood circulation
is_a: GO:1903523 ! negative regulation of blood circulation
relationship: negatively_regulates GO:0120275 ! cerebral blood circulation

[Term]
id: GO:0120279
name: Z granule
namespace: cellular_component
def: "A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells that are distinct from, but colocalize with or are adjacent to, P granules and mutator foci and are associated with RNA metabolism. Z granules have been observed in C. elegans." [GOC:dr, GOC:krc, PMID:29769721, PMID:31378614, PMID:32650583]
synonym: "germline granule" BROAD []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
relationship: part_of GO:0060293 ! germ plasm

[Term]
id: GO:0120280
name: ciliary pro-basal body
namespace: cellular_component
def: "The cilary pro-basal body is an immature, partially assembled form of a ciliary basal body found next to the basal body of a cilium. Pro-basal bodies are not capable of nucleating a cilium. As the cell progresses through the cell cycle, continuing assembly will convert the pro-basal body into a mature basal body that is capable of nucleating a cilium." [ISBN:0198547684]
comment: Pro-basal bodies are distinct from basal bodies as they are not at the base of a cilium and are not capable of nucleating a cilium. While immature, they contain some structures in common with the mature basal body and also may contain proteins unique to the immature state. Note that cilia and eukaryotic flagella are deemed to be equivalent. In many eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. In other eukaryotic cells, centrioles are not involved in cell division but only in cilium assembly, which is thought to be the ancestral role of the centriole/basal body.
synonym: "flagellar pro-basal body" EXACT [GOC:ach]
synonym: "flagellar probasal body" EXACT [GOC:krc]
synonym: "pro-basal body" BROAD [GOC:ach]
synonym: "pro-centriole" BROAD [GOC:ach]
synonym: "probasal body" BROAD [GOC:krc]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0120281
name: autolysosome membrane
namespace: cellular_component
def: "A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded." [GOC:krc, GOC:nhn, PMID:17182262, PMID:24657946, PMID:26382870, PMID:32047650]
is_a: GO:0005765 ! lysosomal membrane
relationship: part_of GO:0044754 ! autolysosome

[Term]
id: GO:0120282
name: autolysosome lumen
namespace: cellular_component
def: "The volume that is enclosed within the autolysosome single-membrane." [GOC:krc, GOC:nhn, PMID:17182262, PMID:24657946, PMID:26382870, PMID:32047650]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0044754 ! autolysosome

[Term]
id: GO:0120283
name: protein serine/threonine kinase binding
namespace: molecular_function
def: "Binding to a protein serine/threonine kinase." [GOC:krc, GOC:sl, PMID:28608965]
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0120284
name: tryptophan binding
namespace: molecular_function
def: "Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:krc]
synonym: "Trp binding" EXACT [GOC:krc]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0120285
name: tyrosine sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine." [GOC:krc, PMID:31498992]
synonym: "tyrosine sensing activity" EXACT []
is_a: GO:0140785 ! amino acid sensor activity

[Term]
id: GO:0120286
name: tryptophan sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan." [GOC:krc, PMID:31498992]
synonym: "tryptophan sensing activity" EXACT []
is_a: GO:0140785 ! amino acid sensor activity

[Term]
id: GO:0120287
name: obsolete regulation of aspartic endopeptidase activity, intramembrane cleaving
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity." [GOC:krc, PMID:32616437]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0120288
name: obsolete negative regulation of aspartic endopeptidase activity, intramembrane cleaving
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity." [GOC:krc, PMID:32616437]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0120289
name: obsolete positive regulation of aspartic endopeptidase activity, intramembrane cleaving
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity." [GOC:krc, PMID:32616437]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0120290
name: stalled replication fork localization to nuclear periphery
namespace: biological_process
def: "A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication." [GOC:krc, GOC:mah, PMID:33159083]
synonym: "stalled replication fork localization to nuclear periphery involved in replication fork processing" EXACT []
is_a: GO:0051641 ! cellular localization
relationship: part_of GO:0031297 ! replication fork processing

[Term]
id: GO:0120291
name: negative regulation of mitotic recombination-dependent replication fork processing
namespace: biological_process
def: "Any process that inhibits or decreases the rate of mitotic recombination-dependent replication fork processing. Suppression of recombination at replication forks is necessary to prevent template switching." [GOC:krc, GOC:mah, PMID:28586299, PMID:30667359, PMID:31149897]
synonym: "maintenance of template fidelity during replication fork processing" EXACT []
synonym: "negative regulation of mitotic recombination involved in replication fork processing" RELATED []
synonym: "negative regulation of template switch recombination involved in replication fork processing" EXACT []
synonym: "suppression of template switching during replication fork processing" EXACT []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1903221 ! regulation of mitotic recombination-dependent replication fork processing
relationship: negatively_regulates GO:1990426 ! mitotic recombination-dependent replication fork processing

[Term]
id: GO:0120292
name: positive regulation of mitotic recombination-dependent replication fork processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:krc, GOC:mah, PMID:23093942, PMID:28586299, PMID:31149897]
synonym: "positive regulation of homologous recombination dependent replication fork recovery" RELATED [PMID:23093942]
synonym: "positive regulation of mitotic recombination involved in replication fork processing" RELATED []
synonym: "positive regulation of recombination-dependent DNA replication" EXACT []
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903221 ! regulation of mitotic recombination-dependent replication fork processing
relationship: positively_regulates GO:1990426 ! mitotic recombination-dependent replication fork processing

[Term]
id: GO:0120293
name: dynein axonemal particle
namespace: cellular_component
def: "An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm." [GOC:krc, PMID:30561330, PMID:32898505, PMID:33263282]
synonym: "DynAP" RELATED []
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0120294
name: peptide serotonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)." [GOC:sp, PMID:14697203]
xref: RHEA:66552
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0120295
name: histone serotonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+)." [GOC:sp, PMID:30867594]
is_a: GO:0120294 ! peptide serotonyltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0120296
name: peptide dopaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)." [GOC:sp, PMID:22858378, PMID:32273471]
xref: RHEA:66556
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0120297
name: histone dopaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+)." [GOC:sp, PMID:32273471]
is_a: GO:0120296 ! peptide dopaminyltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0120298
name: peptide noradrenalinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)." [GOC:sp, PMID:22858378]
xref: RHEA:66560
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0120299
name: peptide histaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]." [GOC:sp, PMID:23022564, PMID:23797785]
xref: RHEA:66564
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0120300
name: peptide lactyltransferase (CoA-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein]." [GOC:sp, PMID:31645732, RHEA:61996]
synonym: "peptide lactyltransferase (CoA dependent) activity" BROAD []
synonym: "peptide lactyltransferase activity" BROAD []
synonym: "peptide lactyltransferase activity (CoA-dependent)" BROAD []
xref: RHEA:61996
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0120301
name: histone lactyltransferase (CoA-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone]." [GOC:sp, PMID:31645732]
synonym: "histone lactyltransferase (CoA dependent) activity" EXACT []
synonym: "histone lactyltransferase activity" BROAD []
synonym: "histone lactyltransferase activity (CoA dependent)" EXACT []
is_a: GO:0120300 ! peptide lactyltransferase (CoA-dependent) activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0120302
name: background adaptation
namespace: biological_process
def: "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity." [GOC:cvs, GOC:krc, PMID:10493760, PMID:29239123, PMID:32898924]
is_a: GO:0009642 ! response to light intensity
is_a: GO:0120305 ! regulation of pigmentation

[Term]
id: GO:0120303
name: visually-mediated background adaptation
namespace: biological_process
def: "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by melanopsin-expressing eye cells." [GOC:cvs, GOC:krc, PMID:29239123, PMID:32898924]
is_a: GO:0120302 ! background adaptation

[Term]
id: GO:0120304
name: integument-mediated background adaptation
namespace: biological_process
def: "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by light sensitive cells in the integument." [GOC:cvs, GOC:krc, PMID:29239123, PMID:32898924]
is_a: GO:0120302 ! background adaptation

[Term]
id: GO:0120305
name: regulation of pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." [GOC:krc]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0043473 ! pigmentation

[Term]
id: GO:0120306
name: cellular response to actin cytoskeletal stress
namespace: biological_process
alt_id: GO:1903956
alt_id: GO:1903957
alt_id: GO:1904804
alt_id: GO:1904805
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perturbations or damage to the actin cytoskeleton." [GOC:krc, GOC:vw, PMID:32915139]
synonym: "cellular response to actin cytoskeleton stress" EXACT [GOC:krc]
synonym: "cellular response to latrunculin A" NARROW [GOC:vw]
synonym: "cellular response to latrunculin B" NARROW [GOC:vw]
synonym: "response to latrunculin A" NARROW [GOC:vw]
synonym: "response to latrunculin B" NARROW [GOC:vw]
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0120307
name: Hechtian strand
namespace: cellular_component
def: "An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely." [GOC:krc, PMID:32397402]
xref: Wikipedia:Hechtian_strand
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0120308
name: axonemal outer doublet assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule." [GOC:ach, GOC:krc, PMID:16278296]
synonym: "axonemal outer doublet biogenesis" EXACT []
synonym: "axonemal outer doublet formation" EXACT []
synonym: "axonemal outer doublet morphogenesis" EXACT []
synonym: "axoneme outer doublet assembly" EXACT []
synonym: "outer doublet assembly" BROAD []
synonym: "outer-doublet microtubule assembly" BROAD []
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0035082 ! axoneme assembly

[Term]
id: GO:0120309
name: cilium attachment to cell body
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the lateral attachment of the cilium to the cell body via the flagellar attachment zone in some trypanosomatid species." [GOC:ach, GOC:krc, PMID:11877446, PMID:18820079, PMID:22623724, PMID:26272611]
synonym: "cilial attachment to cell body" EXACT [GOC:ach]
synonym: "ciliary attachment to cell body" EXACT [GOC:ach]
synonym: "flagellar attachment to cell body" EXACT [GOC:ach]
synonym: "flagellum attachment to cell body" EXACT [GOC:ach]
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0044782 ! cilium organization

[Term]
id: GO:0120310
name: amastigogenesis
namespace: biological_process
def: "The morphological, biochemical and genetic changes that induce the differentiation of metacyclic parasites into amastigotes in some of the Trypanosomatidae species such as Leishmania parasites and Trypanosoma cruzi. This process occurs inside the cells of the mammalian hosts, particularly in macrophages and other phagocytic cells for Leishmania parasites." [DOI:10.5772/intechopen.84639, GOC:ach, GOC:krc, PMID:12377273, PMID:13129524, PMID:26752404]
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0120311
name: ciliary pro-basal body maturation
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium." [GOC:ach, GOC:krc, PMID:26862392]
synonym: "flagellar pro-basal body maturation" RELATED [GOC:ach]
synonym: "flagellar probasal body maturation" RELATED [GOC:ach]
synonym: "pro-basal body maturation" RELATED [GOC:ach]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032053 ! ciliary basal body organization

[Term]
id: GO:0120312
name: ciliary basal body segregation
namespace: biological_process
def: "The process in which the duplicated basal bodies migrate in pairs to the mitotic poles of the nucleus and results in equal distribution in the daughter cells. Ciliary basal body segregation ensures inheritance of the duplicated mitochondrial DNA to the two daughter cells in the Trypanosoma parasites." [GOC:ach, GOC:krc, PMID:1876188, PMID:26272611, PMID:26862392, PMID:27252853, PMID:4055898]
synonym: "ciliary basal body separation" NARROW [GO:ach]
synonym: "microtubule basal body segregation" EXACT [GO:ach]
synonym: "microtubule basal body separation" NARROW [GO:ach]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0120313
name: regulation of oocyte karyosome formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [GOC:ha, GOC:krc, PMID:33382409]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0030717 ! oocyte karyosome formation

[Term]
id: GO:0120314
name: negative regulation of oocyte karyosome formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [GOC:ha, GOC:krc, PMID:33382409]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0120313 ! regulation of oocyte karyosome formation
is_a: GO:2000242 ! negative regulation of reproductive process
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0030717 ! oocyte karyosome formation

[Term]
id: GO:0120315
name: positive regulation of oocyte karyosome formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [GOC:ha, GOC:krc, PMID:33382409]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0120313 ! regulation of oocyte karyosome formation
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0030717 ! oocyte karyosome formation

[Term]
id: GO:0120316
name: sperm flagellum assembly
namespace: biological_process
def: "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium)." [GOC:krc, PMID:32791035]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044458 ! motile cilium assembly
relationship: part_of GO:0007286 ! spermatid development
relationship: part_of GO:0030317 ! flagellated sperm motility

[Term]
id: GO:0120317
name: sperm mitochondrial sheath assembly
namespace: biological_process
def: "The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:krc, PMID:32791035]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0120316 ! sperm flagellum assembly

[Term]
id: GO:0120318
name: olfactory sociosexual communication
namespace: biological_process
def: "The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system." [GOC:krc, PMID:17935991]
comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior.
is_a: GO:0007610 ! behavior
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms

[Term]
id: GO:0120319
name: long-chain fatty acid omega-1 hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:nhn, PMID:18577768, PMID:22772592, PMID:24242247, RHEA:60936]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
synonym: "cytochrome P450 fatty acid omega-1 hydroxylase activity" RELATED []
xref: RHEA:60936
is_a: GO:0120502 ! fatty acid omega-1 hydroxylase activity

[Term]
id: GO:0120320
name: lateral pseudopodium retraction
namespace: biological_process
def: "The myosin-based contraction and retraction of a lateral pseudopodium." [GOC:krc, GOC:pf, PMID:12953059, PMID:15483055, PMID:17623773]
synonym: "lateral pseudopodium suppression" RELATED []
is_a: GO:0031270 ! pseudopodium retraction

[Term]
id: GO:0120321
name: nuclear envelope adjacent to nuclear pore complex
namespace: cellular_component
def: "The region of the nuclear envelope situated in close proximity to a nuclear pore complex." [GOC:mah, PMID:21802294, PMID:24184107]
synonym: "associated with the nuclear pore" RELATED [GOC:mah]
synonym: "nuclear envelope adjacent to NPC" EXACT [GOC:mah]
synonym: "nuclear envelope periphery of the nuclear pore complex" EXACT [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0120322
name: lipid modification by small protein conjugation
namespace: biological_process
def: "A lipid modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target lipid." [GOC:sp, PMID:34012115]
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0120323
name: lipid ubiquitination
namespace: biological_process
def: "The process in which one or more ubiquitin groups are added to a lipid." [GOC:sp, PMID:34012115]
is_a: GO:0120322 ! lipid modification by small protein conjugation

[Term]
id: GO:0120324
name: procyclogenesis
namespace: biological_process
def: "The morphological, biochemical and genetic changes that induce the differentiation of bloodstream form trypomastigotes into procyclic trypomastigotes in some of the Trypanosomatidae species such as Trypanosoma brucei. This process occurs inside the midgut of the tsetse fly vectors in T. brucei." [GOC:ach, PMID:10593184, PMID:1698624, PMID:17997129, PMID:3194362, PMID:3194363]
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0120325
name: NuRD complex binding
namespace: molecular_function
def: "Binding to a NuRD complex." [GOC:krc, GOC:lb, PMID:25150861]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0120326
name: appressorium-mediated entry into host
namespace: biological_process
def: "Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ach, GOC:krc, PMID:14731267, PMID:22589729]
synonym: "appressorium-mediated host invasion" EXACT [GOC:ach]
synonym: "appressorium-mediated host penetration" EXACT [GOC:ach]
synonym: "appressorium-mediated invasion into host" EXACT [GOC:ach]
synonym: "appressorium-mediated penetration into host" EXACT [GOC:ach]
is_a: GO:0044409 ! symbiont entry into host

[Term]
id: GO:0120327
name: telopode
namespace: cellular_component
def: "A telopode is a plasma membrane bounded cell projection that is present on a telocyte and is tens to hundreds of microns long. Telopodes form a labyrinthine system communicating through gap junctions." [GOC:krc, MESH:D000067617, PMID:20367664]
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0120328
name: ATP-dependent DNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
def: "Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis." [GOC:krc, PMID:31955845, PMID:32437639, RHEA:68984]
xref: RHEA:68984
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0120329
name: protein localization to centriolar satellite
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a centriolar satellite." [PMID:34782749]
synonym: "protein localisation to centriolar satellite" EXACT []
is_a: GO:0071539 ! protein localization to centrosome

[Term]
id: GO:0120330
name: rixosome complex
namespace: cellular_component
def: "A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans." [GOC:vw, PMID:32491985, PMID:35355014]
synonym: "rix1 complex" NARROW []
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0120331
name: endothelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endothelial tube." [GOC:sl, PMID:23239824]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0061154 ! endothelial tube morphogenesis

[Term]
id: GO:0120332
name: host-mediated regulation of oral microbiota composition
namespace: biological_process
def: "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells, such as the bacteria, in the mouth." [PMID:31882545]
synonym: "host-induced regulation of oral microbiota composition" RELATED []
is_a: GO:0048872 ! homeostasis of number of cells
is_a: GO:0051851 ! modulation by host of symbiont process

[Term]
id: GO:0120333
name: radial spoke 1
namespace: cellular_component
def: "The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is most proximal to the base of the cilium. Radial spoke 1 (RS1), similarly to radial spoke 2, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS1 is connected to the tail of the inner dynein arm a/d." [GOC:krc, PMID:22754630]
synonym: "RS1" RELATED [PMID:22754630]
is_a: GO:0001534 ! radial spoke

[Term]
id: GO:0120334
name: radial spoke 2
namespace: cellular_component
def: "The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is immediately distal to radial spoke 1 (RS1). Radial spoke 2 (RS2), similarly to RS1, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS2 is connected to the tail of the inner dynein arm c." [GOC:krc, PMID:22754630]
synonym: "RS2" RELATED [PMID:22754630]
is_a: GO:0001534 ! radial spoke

[Term]
id: GO:0120335
name: radial spoke 3
namespace: cellular_component
def: "Radial spoke 3 (RS3), when present, is the most distal of each group of radial spokes, whether grouped as triplets or doublets. RS3 has significantly different morphology and protein composition than RS1 and RS2 and also extends at a slant from the microtubule doublet, rather than perpendicularly like RS1 and RS2. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), RS3 is represented only as a stump attached to the A-microtubule lacking the rest of the stalk structure and entirely lacking the head structure." [GOC:krc, ISBN:0124325653, PMID:22754630, PMID:25694453, PMID:9450971]
synonym: "RS3" RELATED [PMID:22754630]
is_a: GO:0001534 ! radial spoke

[Term]
id: GO:0120336
name: radial spoke head 1
namespace: cellular_component
def: "The portion of the radial spoke 1 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme." [GOC:krc, PMID:22754630, PMID:348711799]
synonym: "radial spokehead 1" EXACT []
is_a: GO:0001535 ! radial spoke head
relationship: part_of GO:0120333 ! radial spoke 1

[Term]
id: GO:0120337
name: radial spoke head 2
namespace: cellular_component
def: "The portion of the radial spoke 2 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme." [GOC:krc, PMID:22754630, PMID:348711799]
synonym: "radial spokehead 2" EXACT []
is_a: GO:0001535 ! radial spoke head
relationship: part_of GO:0120334 ! radial spoke 2

[Term]
id: GO:0120338
name: radial spoke head 3
namespace: cellular_component
def: "The portion of the radial spoke 3 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme." [GOC:krc, PMID:22754630, PMID:348711799]
synonym: "radial spokehead 3" EXACT []
is_a: GO:0001535 ! radial spoke head
relationship: part_of GO:0120335 ! radial spoke 3

[Term]
id: GO:0120339
name: radial spoke base
namespace: cellular_component
def: "The short portion of the radial spoke that is directly anchored to the A microtubule of an axonemal microtubule doublet." [GOC:krc, PMID:22754630, PMID:25694453]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0120340
name: radial spoke base 1
namespace: cellular_component
def: "The short portion of the radial spoke 1 (RS1) that is directly anchored to the A microtubule of an axonemal microtubule doublet." [GOC:krc, PMID:22754630, PMID:25694453]
is_a: GO:0120339 ! radial spoke base
relationship: part_of GO:0120333 ! radial spoke 1

[Term]
id: GO:0120341
name: radial spoke base 2
namespace: cellular_component
def: "The short portion of the radial spoke 2 (RS2) that is directly anchored to the A microtubule of an axonemal microtubule doublet." [GOC:krc, PMID:22754630, PMID:25694453]
is_a: GO:0120339 ! radial spoke base
relationship: part_of GO:0120334 ! radial spoke 2

[Term]
id: GO:0120342
name: radial spoke base 3
namespace: cellular_component
def: "The short portion of the radial spoke 3 (RS3 )that is directly anchored to the A microtubule of an axonemal microtubule doublet." [GOC:krc, PMID:22754630, PMID:25694453]
is_a: GO:0120339 ! radial spoke base
relationship: part_of GO:0120335 ! radial spoke 3

[Term]
id: GO:0120343
name: radial spoke neck
namespace: cellular_component
def: "The radial spoke neck is a complex that connects the spoke stalk to the head." [GOC:krc, PMID:22754630]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0120500
name: NAE1-UBA3 complex
namespace: cellular_component
def: "A heterodimeric E1 complex that activates the ubiquitin-like protein NEDD8. In humans the subunits are NAE1 (also known as APPBP1) and UBA3." [PMID:12740388, PMID:21931660]
synonym: "APPBP1-UBA3 complex" EXACT []
synonym: "NAE" EXACT []
synonym: "NEDD8 activating enzyme" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0120501
name: F-actin monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionyl-[F-actin] + NADPH + O2 + H+ = L-methionyl-(R)-S-oxide-[F-actin] + NADP+ + H2O." [RHEA:51308]
xref: EC:1.14.13.225
xref: RHEA:51308
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0120502
name: fatty acid omega-1 hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [RHEA:44548]
xref: RHEA:44548
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0120503
name: medium-chain fatty acid omega-1 hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an (omega-1)-ethyl medium-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [PMID:35934685]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
is_a: GO:0120502 ! fatty acid omega-1 hydroxylase activity

[Term]
id: GO:0120504
name: EXT1-EXT2 complex
namespace: cellular_component
def: "A heterodimeric complex capable of glycosyltransferase activity required for the elongation of heparan sulfate chains. In humans, the complex consists of EXT1 and EXT2. In Drosophila, the complex consists of ttv and sotv." [GOC:sjm, PMID:14998928, PMID:36402845, PMID:36593275]
synonym: "exostosin complex" EXACT []
synonym: "EXT1-EXT2 heparan sulfate biosynthesis complex" EXACT []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0120505
name: histone H3K79 monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl79-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl79-[histone H3] + S-adenosyl-L-homocysteine." [PMID:14732680, PMID:15371351, RHEA:60332]
xref: RHEA:60332
is_a: GO:0031151 ! histone H3K79 methyltransferase activity

[Term]
id: GO:0120506
name: histone H3K79 dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl79-[histone H3] + 2 S-adenosyl-L-methionine = 2H+ + N6,N6-methyl-L-lysyl79-[histone H3] + 2 S-adenosyl-L-homocysteine." [PMID:14732680, PMID:15371351]
is_a: GO:0031151 ! histone H3K79 methyltransferase activity

[Term]
id: GO:0120507
name: tRNA-guanine transglycosylase complex
namespace: cellular_component
def: "A protein complex that catalyzes the base-exchange of a guanine residue with queuine at the wobble position of the anticodon of tRNAs. The eukaryotic tRNA-guanine transglycosylase exists as a heterodimer of a catalytic subunit (QTRT1 in humans) and an accessory subunit (QTRT2 in humans), whereas the bacterial enzyme is homodimeric." [GOC:sjm, PMID:20354154, PMID:38181786]
synonym: "queuine tRNA-ribosyltransferase complex" EXACT []
synonym: "TGT" EXACT []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0120508
name: GDP-mannose pyrophosphorylase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the reaction of GTP and mannose-1-phosphate to form GDP-mannose. The complex is a homodimer in most bacteria and a heterodimer in most eukaryotes. In humans, it is composed of a catalytic beta subunit (GMPPB) and a regulatory alpha subunit (GMPPA)." [GOC:sjm, PMID:33986552]
synonym: "GMPPA-GMPPB complex" EXACT []
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0120509
name: hydroxypyruvate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 3-hydroxypyruvate + NADPH + H+." [RHEA:18657]
xref: MetaCyc:RXN0-300
xref: RHEA:18657
is_a: GO:0016618 ! hydroxypyruvate reductase [NAD(P)H] activity

[Term]
id: GO:0120510
name: mitochondrial [4Fe-4S] assembly complex
namespace: cellular_component
def: "A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in mitochondria. In S. cerevisiae, it consists of Isa1 and Isa2. In humans it consists of ISCA1 and ISCA2. Additional proteins may be present." [PMID:25347204, PMID:29079644, PMID:33711344, PMID:34660592]
synonym: "iron-sulfur assembly complex" RELATED [PMID:34660592]
synonym: "ISA complex" EXACT [PMID:34660592]
is_a: GO:0098798 ! mitochondrial protein-containing complex
is_a: GO:1990229 ! iron-sulfur cluster assembly complex

[Term]
id: GO:0120511
name: methyl farnesoate epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]." [PMID:23586995, PMID:38741075, RHEA:43728]
synonym: "CYP15A1 activity" RELATED [EC:1.14.14.127]
xref: EC:1.14.14.127
xref: MetaCyc:RXN-11621
xref: RHEA:43728
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0120512
name: farnesoate epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]." [PMID:22412378, PMID:38741075, RHEA:43724]
synonym: "CYP15C1 activity" RELATED [EC:1.14.14.128]
xref: EC:1.14.14.128
xref: MetaCyc:RXN-11770
xref: RHEA:43724
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0120513
name: 2-(3-amino-3-carboxypropyl)histidine synthase complex
namespace: cellular_component
def: "A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes." [GOC:sjm, PMID:24422557, PMID:31463593]
synonym: "Dph1-Dph2 complex" EXACT []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0120514
name: 2-hydroxyflavanone C-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H+ + UDP." [RHEA:51504]
xref: EC:2.4.1.360
xref: MetaCyc:RXN-18732
xref: RHEA:51504
is_a: GO:0016758 ! hexosyltransferase activity

[Term]
id: GO:0120515
name: fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate." [RHEA:38883]
xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN
xref: RHEA:38883
is_a: GO:0015645 ! fatty acid ligase activity
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0120516
name: diacylglycerol lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+." [RHEA:32731]
xref: MetaCyc:RXN-19279
xref: RHEA:32731
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0120517
name: inositol pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol pentakisphosphate + ATP = inositol hexakisphosphate + ADP + H+." [GOC:curators]
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0180030 ! inositol phosphate kinase activity

[Term]
id: GO:0120518
name: peptide-methionine-alpha-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-methionyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-methionyl-[protein]." [RHEA:75239]
xref: RHEA:75239
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity

[Term]
id: GO:0120519
name: tubulin N-terminal N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H+ + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]. The N-terminus of both alpha- and beta-tubulin are acetylated." [EC:2.3.1.308, RHEA:69607]
xref: EC:2.3.1.308
xref: KEGG_REACTION:R12978
xref: MetaCyc:RXN-22633
xref: RHEA:69607
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity

[Term]
id: GO:0120520
name: free fatty acid 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O. Note that the substrate is a free fatty acid, not a fatty acyl chain within a sphingolipid." [GOC:sjm, RHEA:38855]
xref: RHEA:38855
is_a: GO:0080132 ! fatty acid 2-hydroxylase activity

[Term]
id: GO:0120521
name: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O." [RHEA:46520]
xref: MetaCyc:RXN3O-4042
xref: RHEA:46520
is_a: GO:0080132 ! fatty acid 2-hydroxylase activity

[Term]
id: GO:0120522
name: short-chain fatty acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + O2 = a short-chain (2E)-enoyl-CoA + H2O2." [RHEA:78859]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
xref: RHEA:78859
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0120523
name: medium-chain fatty acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + O2 = a medium-chain (2E)-enoyl-CoA + H2O2." [RHEA:78855]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
xref: RHEA:78855
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0120524
name: long-chain fatty acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + O2 = a long-chain (2E)-enoyl-CoA + H2O2." [RHEA:78851]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
xref: RHEA:78851
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0120525
name: choline trimethylamine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline = acetaldehyde + trimethylamine." [RHEA:35095]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
xref: EC:4.3.99.4
xref: KEGG_REACTION:R10285
xref: MetaCyc:RXN-13946
xref: RHEA:35095
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0120526
name: homomethionine N-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]." [RHEA:51972]
xref: EC:1.14.14.42
xref: KEGG_REACTION:R11646
xref: MetaCyc:RXN-18175
xref: RHEA:51972
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0120527
name: aliphatic desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H+." [RHEA:52724]
xref: EC:2.8.2.38
xref: MetaCyc:RXN-18179
xref: RHEA:52724
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0120528
name: 2-(omega-methylthio)alkylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reactions: a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O and a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O." [EC:4.2.1.170]
xref: EC:4.2.1.170
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0120529
name: secoisolariciresinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 H(+) + 2 NADH." [RHEA:33887]
xref: EC:1.1.1.331
xref: KEGG_REACTION:R10129
xref: MetaCyc:RXN-13433
xref: RHEA:33887
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0120530
name: UDP-alpha-D-glucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate." [MetaCyc:PWY-7343]
synonym: "UDP-D-glucose biosynthesis" EXACT [MetaCyc:PWY-7343]
synonym: "UDP-D-glucose biosynthetic process" EXACT []
synonym: "UDP-glucose biosynthesis" EXACT []
synonym: "uridine diphosphate glucose biosynthesis" EXACT []
synonym: "uridine diphosphate glucose biosynthetic process" EXACT []
xref: MetaCyc:PWY-7343
is_a: GO:0006011 ! UDP-alpha-D-glucose metabolic process
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process

[Term]
id: GO:0120531
name: prenyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the transfer of a prenyl group from a prenyl diphosphate donor to an isopentenyl diphosphate (acceptor), resulting in chain elongation of allylic diphosphate substrates." [PMID:12135472, PMID:26216239]
synonym: "IPPS activity" EXACT [PMID:12135472]
synonym: "isoprenyl pyrophosphate synthase activity" EXACT [PMID:12135472]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0120532
name: glycosaminoglycan-protein linkage region biosynthetic process
namespace: biological_process
def: "The formation of a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate) on specific serine residues of a core protein, on to which dermatan sulfate, chondroitin sulfate, heparan sulfate or heparin glycosaminoglycans may be assembled to synthesise the corresponding proteoglycan." [MetaCyc:PWY-6557]
synonym: "Glycosaminoglycan biosynthesis, linkage tetrasaccharide" EXACT []
synonym: "glycosaminoglycan-protein linkage region biosynthesis" EXACT [MetaCyc:PWY-6557]
xref: MetaCyc:PWY-6557
is_a: GO:0030166 ! proteoglycan biosynthetic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process
relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process
relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0120533
name: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (non-phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O = (2R)-3-phosphoglycerate + NAD(P)H + 2 H+." [EC:1.2.1.90]
synonym: "GAPN activity" BROAD [EC:1.2.1.90]
synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" BROAD [EC:1.2.1.90]
xref: EC:1.2.1.90
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0140001
name: morula formation
namespace: biological_process
def: "The initial formation of a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0140002
name: H3K4me3 histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone H3 trimethylated at lysine 4." [PMID:15647753, PMID:23318260]
synonym: "H3-K4me3 modified histone binding" NARROW []
synonym: "H3K4me3 modified histone binding" NARROW []
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:0140003
name: H3K36me3 histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone H3 trimethylated at lysine 36." [PMID:15489290, PMID:16364921]
synonym: "H3-K36me3 modified histone binding" NARROW []
synonym: "H3K36me3 modified histone binding" NARROW []
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:0140004
name: H3Q5ser histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone H3 serotonylated at glutamine 5." [PMID:34144982]
synonym: "H3Q5-serotonin histone reader activity" EXACT []
synonym: "H3Q5-serotonin modified histone binding" NARROW []
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:0140005
name: H4K20me2 histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone H4 dimethylated at lysine 20." [PMID:22150589]
synonym: "H4K20me2 modified histone binding" NARROW []
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:0140007
name: KICSTOR complex
namespace: cellular_component
def: "A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2." [PMID:28199306]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0140009
name: L-aspartate import across plasma membrane
namespace: biological_process
def: "The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000069, PMID:7914198]
is_a: GO:0070778 ! L-aspartate transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane

[Term]
id: GO:0140010
name: D-aspartate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-aspartate from one side of a membrane to the other." [GO_REF:0000070, PMID:7914198]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity

[Term]
id: GO:0140013
name: meiotic nuclear division
namespace: biological_process
def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324]
subset: goslim_generic
synonym: "meiosis" EXACT []
is_a: GO:0000280 ! nuclear division
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0140014
name: mitotic nuclear division
namespace: biological_process
def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
synonym: "mitosis" EXACT []
is_a: GO:0000280 ! nuclear division
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:0140018
name: regulation of cytoplasmic translational fidelity
namespace: biological_process
def: "Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code." [PMID:22768388]
is_a: GO:0006450 ! regulation of translational fidelity
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation

[Term]
id: GO:0140020
name: DNA methyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses DNA methyltransferase activity." [PMID:20939822, PMID:24947342]
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0140021
name: mitochondrial ADP transmembrane transport
namespace: biological_process
def: "The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:2541251]
is_a: GO:0015866 ! ADP transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0140022
name: cnida
namespace: cellular_component
def: "A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria." [Wikipedia:Cnida#Structure_and_function]
synonym: "cnidae (plural)" EXACT []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0140023
name: tRNA adenosine deamination to inosine
namespace: biological_process
def: "The removal of an amine group from an adenosine to produce inosine within a tRNA molecule." [PMID:27974624]
synonym: "A-to-I tRNA editing" EXACT []
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0140024
name: plus-end-directed endosome transport along mitotic spindle midzone microtubule
namespace: biological_process
def: "The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination." [PMID:24803650, PMID:25706234]
is_a: GO:0072383 ! plus-end-directed vesicle transport along microtubule

[Term]
id: GO:0140025
name: contractile vacuole tethering involved in discharge
namespace: biological_process
def: "The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [PMID:22323285]
synonym: "contractile vacuole tethering to plasma membrane" NARROW []
is_a: GO:0006903 ! vesicle targeting
is_a: GO:0090522 ! vesicle tethering involved in exocytosis
relationship: part_of GO:0070177 ! contractile vacuole discharge

[Term]
id: GO:0140026
name: contractile vacuole dissociation from plasma membrane
namespace: biological_process
def: "The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network." [PMID:22323285]
synonym: "contractile vacuole detethering from plasma membrane" EXACT []
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0140027
name: contractile vacuole localization
namespace: biological_process
def: "The directed movement of the contractile vacuole to a specific location." [PMID:19687255]
synonym: "establishment of contractile vacuole localization" NARROW []
is_a: GO:0051648 ! vesicle localization
is_a: GO:1990849 ! vacuolar localization

[Term]
id: GO:0140028
name: pore formation during contractile vacuole discharge
namespace: biological_process
def: "The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes." [PMID:22323285, Wikipedia:Exocytosis]
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0070177 ! contractile vacuole discharge

[Term]
id: GO:0140029
name: exocytic process
namespace: biological_process
def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0006887 ! exocytosis

[Term]
id: GO:0140030
name: modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon post-translation modification of the target protein." [PMID:26060076]
comment: This term should only be used when the binding is shown to require a post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
synonym: "modified protein binding" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0140031
name: phosphorylation-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon phosphorylation of the target protein." [PMID:26060076]
comment: This term should only be used when the binding is shown to require phosphorylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of phosphorylation. It may be that the phosphorylation causes a conformational change that allows binding of the protein to another region; this type of phosphorylation-dependent protein binding is valid for annotation to this term.
is_a: GO:0140030 ! modification-dependent protein binding

[Term]
id: GO:0140032
name: glycosylation-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon glycosylation of the target protein." [PMID:26060076]
comment: This term should only be used when the binding is shown to require glycosylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of glycosylation. It may be that the glycosylation causes a conformational change that allows binding of the protein to another region; this type of glycosylation-dependent protein binding is valid for annotation to this term.
is_a: GO:0140030 ! modification-dependent protein binding

[Term]
id: GO:0140033
name: acetylation-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon acetylation of the target protein." [PMID:26060076]
comment: This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term.
is_a: GO:0140030 ! modification-dependent protein binding

[Term]
id: GO:0140034
name: methylation-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon methylation of the target protein." [PMID:26060076]
comment: This term should only be used when the binding is shown to require methylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of methylation. It may be that the methylation causes a conformational change that allows binding of the protein to another region; this type of methylation-dependent protein binding is valid for annotation to this term.
is_a: GO:0140030 ! modification-dependent protein binding

[Term]
id: GO:0140035
name: ubiquitin-like protein reader activity
namespace: molecular_function
def: "A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way." [PMID:26060076]
comment: This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
synonym: "ubiquitination-like modification-dependent protein binding" EXACT []
synonym: "ubiquitination-like protein reader activity" EXACT []
is_a: GO:0030674 ! protein-macromolecule adaptor activity
is_a: GO:0140030 ! modification-dependent protein binding

[Term]
id: GO:0140036
name: ubiquitin-modified protein reader activity
namespace: molecular_function
def: "A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way." [PMID:26060076]
comment: This term should only be used when the binding is shown to require ubiquitination of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitination. It may be that the ubiquitination causes a conformational change that allows binding of the protein to another region; this type of ubiquitination-dependent protein binding is valid for annotation to this term.
synonym: "ubiquitin-dependent protein binding" EXACT []
is_a: GO:0140035 ! ubiquitin-like protein reader activity

[Term]
id: GO:0140037
name: SUMO-modified protein reader activity
namespace: molecular_function
def: "A molecular adaptor that recognizes and binds a target protein containing a SUMO modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way." [PMID:26060076]
comment: This term should only be used when the binding is shown to require sumoylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of sumoylation. It may be that the sumoylation causes a conformational change that allows binding of the protein to another region; this type of sumoylation-dependent protein binding is valid for annotation to this term.
synonym: "SUMO-dependent protein binding" EXACT []
is_a: GO:0140035 ! ubiquitin-like protein reader activity

[Term]
id: GO:0140039
name: cell-cell adhesion in response to extracellular stimulus
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus." [PMID:14996911]
is_a: GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0140040
name: mitochondrial polycistronic RNA processing
namespace: biological_process
def: "The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs." [PMID:20211597]
is_a: GO:0031426 ! polycistronic mRNA processing
is_a: GO:0090615 ! mitochondrial mRNA processing

[Term]
id: GO:0140041
name: cellular detoxification of methylglyoxal
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal. These may include chemical modification or transport of methylglyoxal away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [PMID:15042280]
is_a: GO:0110095 ! cellular detoxification of aldehyde
relationship: part_of GO:0097238 ! cellular response to methylglyoxal

[Term]
id: GO:0140042
name: lipid droplet formation
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts of a lipid droplet." [PMID:28011631]
synonym: "adiposome formation" EXACT []
synonym: "lipid body formation" EXACT []
synonym: "lipid particle formation" EXACT []
is_a: GO:0034389 ! lipid droplet organization
is_a: GO:0140694 ! membraneless organelle assembly
relationship: part_of GO:0019915 ! lipid storage

[Term]
id: GO:0140043
name: lipid droplet localization to prospore membrane leading edge
namespace: biological_process
def: "Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge." [PMID:28011631]
synonym: "adiposome localization to ascospore-type prospore membrane leading edge" EXACT []
synonym: "adiposome localization to forespore membrane leading edge" RELATED []
synonym: "adiposome localization to FSM membrane leading edge" EXACT []
synonym: "lipid body localization to ascospore-type prospore membrane leading edge" EXACT []
synonym: "lipid body localization to forespore membrane leading edge" RELATED []
synonym: "lipid body localization to FSM membrane leading edge" EXACT []
synonym: "lipid particle localization to ascospore-type prospore membrane leading edge" EXACT []
synonym: "lipid particle localization to forespore membrane leading edge" RELATED []
synonym: "lipid particle localization to FSM membrane leading edge" EXACT []
is_a: GO:0010876 ! lipid localization
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0140048
name: manganese ion export across plasma membrane
namespace: biological_process
def: "The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region." [PMID:25319704]
synonym: "manganese ion export from cell" EXACT []
is_a: GO:0071421 ! manganese ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0140049
name: regulation of endocardial cushion to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427]
is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition
relationship: regulates GO:0090500 ! endocardial cushion to mesenchymal transition

[Term]
id: GO:0140050
name: negative regulation of endocardial cushion to mesenchymal transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427]
is_a: GO:0062044 ! negative regulation of cardiac epithelial to mesenchymal transition
is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition
relationship: negatively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition

[Term]
id: GO:0140051
name: positive regulation of endocardial cushion to mesenchymal transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427]
is_a: GO:0062043 ! positive regulation of cardiac epithelial to mesenchymal transition
is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition
relationship: positively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition

[Term]
id: GO:0140052
name: cellular response to oxidised low-density lipoprotein particle stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus." [GOC:aruk, GOC:BHF, PMID:20037584, PMID:27607416]
synonym: "cellular response to ox-LDL particle stimulus" EXACT []
synonym: "cellular response to oxidised LDL particle stimulus" EXACT []
synonym: "cellular response to oxidized LDL particle stimulus" EXACT []
synonym: "cellular response to oxidized low-density lipoprotein particle stimulus" EXACT []
synonym: "cellular response to oxLDL particle stimulus" EXACT []
is_a: GO:0071404 ! cellular response to low-density lipoprotein particle stimulus

[Term]
id: GO:0140053
name: mitochondrial gene expression
namespace: biological_process
def: "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308]
subset: goslim_generic
subset: goslim_pombe
is_a: GO:0010467 ! gene expression

[Term]
id: GO:0140056
name: organelle localization by membrane tethering
namespace: biological_process
def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684]
subset: goslim_pombe
is_a: GO:0022406 ! membrane docking
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0140057
name: vacuole-mitochondria membrane tethering
namespace: biological_process
def: "The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:27875684]
is_a: GO:0140056 ! organelle localization by membrane tethering

[Term]
id: GO:0140058
name: neuron projection arborization
namespace: biological_process
def: "The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:aruk, GOC:bc, PMID:17114044, PMID:23270857, PMID:23764288]
synonym: "branching morphogenesis of a neurite" RELATED []
synonym: "branching morphogenesis of a neuron projection" RELATED []
synonym: "neurite arborization" EXACT []
synonym: "neurite branching" EXACT [GOC:aruk, GOC:bc, PMID:17114044]
synonym: "neuron projection branching" EXACT [GOC:aruk, GOC:bc, PMID:17114044]
is_a: GO:0048812 ! neuron projection morphogenesis

[Term]
id: GO:0140059
name: dendrite arborization
namespace: biological_process
def: "The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:23270857]
is_a: GO:0048813 ! dendrite morphogenesis
is_a: GO:0140058 ! neuron projection arborization

[Term]
id: GO:0140060
name: axon arborization
namespace: biological_process
def: "The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches." [GOC:aruk, GOC:bc, PMID:23764288]
is_a: GO:0007409 ! axonogenesis
is_a: GO:0140058 ! neuron projection arborization

[Term]
id: GO:0140061
name: obsolete 5-hydroxymethylcytosine dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2." [PMID:27918559]
comment: This term was obsoleted because it is a substep of the reaction represented by 5-methylcytosine dioxygenase activity ; GO:0070579.
synonym: "5hmC dioxygenase" EXACT []
is_obsolete: true
replaced_by: GO:0070579

[Term]
id: GO:0140062
name: obsolete 5-formylcytosine dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2." [PMID:27918559]
comment: This term was obsoleted because it is a substep of the reaction represented by 5-methylcytosine dioxygenase activity ; GO:0070579.
synonym: "5fC dioxygenase" EXACT []
is_obsolete: true
replaced_by: GO:0070579

[Term]
id: GO:0140064
name: peptide crotonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide." [PMID:25818647]
synonym: "protein crotonyltransferase activity" RELATED []
xref: RHEA:53908
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0140065
name: peptide butyryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide." [PMID:27105113]
synonym: "protein butyryltransferase activity" RELATED []
xref: RHEA:53912
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0140066
name: peptidyl-lysine crotonylation
namespace: biological_process
def: "The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid." [PMID:25818647, Wikipedia:crotonyl]
subset: gocheck_obsoletion_candidate
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0140067
name: peptidyl-lysine butyrylation
namespace: biological_process
def: "The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid." [PMID:27105113, Wikipedia:butyryl]
subset: gocheck_obsoletion_candidate
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0140068
name: histone crotonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone." [PMID:25818647]
is_a: GO:0140064 ! peptide crotonyltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0140069
name: histone butyryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone." [PMID:27105113]
is_a: GO:0140065 ! peptide butyryltransferase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0140070
name: hydrogen peroxide channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of hydrogen peroxide through a transmembrane aqueous pore or channel." [PMID:23541115, PMID:27256569]
synonym: "hydrogen peroxide transmembrane transporter activity" RELATED []
is_a: GO:0015267 ! channel activity
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity

[Term]
id: GO:0140074
name: cardiac endothelial to mesenchymal transition
namespace: biological_process
def: "A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes." [GOC:BHF, GOC:nc, PMID:16162442, PMID:26053665]
synonym: "EndMT" EXACT [PMID:28181491]
synonym: "EndoMT" EXACT []
is_a: GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0140075
name: regulation of lipoprotein transport
namespace: biological_process
def: "Any process that controls lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]
is_a: GO:0051223 ! regulation of protein transport
relationship: regulates GO:0042953 ! lipoprotein transport

[Term]
id: GO:0140076
name: negative regulation of lipoprotein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:0140075 ! regulation of lipoprotein transport
relationship: negatively_regulates GO:0042953 ! lipoprotein transport

[Term]
id: GO:0140077
name: positive regulation of lipoprotein transport
namespace: biological_process
def: "Any process that activates or increases the rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:0140075 ! regulation of lipoprotein transport
relationship: positively_regulates GO:0042953 ! lipoprotein transport

[Term]
id: GO:0140078
name: class I DNA-(apurinic or apyrimidinic site) endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, RHEA:66592]
comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
synonym: "AP endonuclease class I activity" RELATED []
synonym: "AP lyase activity" RELATED []
synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT []
synonym: "class I AP endonuclease activity" RELATED []
synonym: "class I DNA-(apurinic or apyrimidinic site) lyase activity" EXACT []
synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT []
synonym: "DNA-(apurinic or apyrimidinic site) lyase activity" EXACT []
xref: EC:4.2.99.18
xref: MetaCyc:4.2.99.18-RXN
xref: RHEA:66592
xref: Wikipedia:AP_endonuclease
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0140080
name: obsolete class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH." [PMID:2519777]
comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.\nThe reason for obsoletion is that there is no longer credible evidence that this function exists.
synonym: "endonuclease III" RELATED []
synonym: "endonuclease IV" RELATED []
xref: Wikipedia:AP_endonuclease
is_obsolete: true

[Term]
id: GO:0140081
name: glycosylated region protein binding
namespace: molecular_function
def: "Binding to a glycosylated region of a protein." [GOC:pg]
is_a: GO:0005515 ! protein binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0140082
name: SUMO-ubiquitin ligase activity
namespace: molecular_function
def: "Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [PMID:28552615]
is_a: GO:0061665 ! SUMO ligase activity

[Term]
id: GO:0140083
name: ATP-dependent protein-DNA unloader activity
namespace: molecular_function
def: "Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction." [PMID:28552615]
synonym: "ATP-dependent protein-DNA unloading activity" EXACT []
synonym: "protein-DNA unloading ATPase activity" EXACT []
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0140084
name: sexual macrocyst formation
namespace: biological_process
def: "The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum." [PMID:16592095, PMID:20089169]
synonym: "macrocyst formation" RELATED []
synonym: "sexual fusion" RELATED []
is_a: GO:0022413 ! reproductive process in single-celled organism

[Term]
id: GO:0140090
name: membrane curvature sensor activity
namespace: molecular_function
def: "Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins." [PMID:25898166]
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0140091
name: mBAF complex
namespace: cellular_component
def: "A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof." [GO:bhm, PMID:11175787, PMID:12620226, PMID:15525990, PMID:8804307, PMID:8895581]
synonym: "muscle-specific BAF complex" EXACT []
synonym: "muscle-specific SWI/SNF complex" EXACT []
synonym: "muscle-type BAF complex" EXACT []
synonym: "muscle-type SWI/SNF complex" EXACT []
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0140092
name: bBAF complex
namespace: cellular_component
def: "A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180." [GOC:bhm, PMID:12368262, PMID:12620226, PMID:15525990, PMID:17640523, PMID:17920018, PMID:8804307, PMID:8895581]
synonym: "brain-specific BAF complex" EXACT []
synonym: "brain-specific SWI/SNF complex" EXACT []
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0140093
name: esBAF complex
namespace: cellular_component
def: "An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C." [GOC:bhm, PMID:19279218, PMID:19279220, PMID:2620226, PMID:8804307, PMID:8895581]
synonym: "embryonic stem cell-specific BAF complex" EXACT []
synonym: "embryonic stem cell-specific SWI/SNF complex" EXACT []
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0140096
name: catalytic activity, acting on a protein
namespace: molecular_function
def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0140097
name: catalytic activity, acting on DNA
namespace: molecular_function
def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid

[Term]
id: GO:0140098
name: catalytic activity, acting on RNA
namespace: molecular_function
def: "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid

[Term]
id: GO:0140101
name: catalytic activity, acting on a tRNA
namespace: molecular_function
def: "Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]
comment: Note that this term excludes activities for which a charged tRNA acts as an amino acid donor.
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0140102
name: catalytic activity, acting on a rRNA
namespace: molecular_function
def: "Catalytic activity that acts to modify a ribosomal RNA." [GOC:molecular_function_refactoring, GOC:pdt]
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0140103
name: catalytic activity, acting on a glycoprotein
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140104
name: molecular carrier activity
namespace: molecular_function
def: "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt]
comment: Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization.
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
xref: Reactome:R-HSA-1449687 "Corticosteroids bind to CBG in blood"
xref: Reactome:R-HSA-3149494 "MMACHC:cob(II)alamin binds MMADHC"
xref: Reactome:R-HSA-3149563 "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria"
xref: Reactome:R-HSA-3159259 "MMAA:MUT binds AdoCbl"
xref: Reactome:R-HSA-3204318 "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140105
name: interleukin-10-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:11244051]
synonym: "IL-10-mediated signaling pathway" EXACT []
synonym: "interleukin-10-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0140107
name: high-affinity potassium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:10629185]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity

[Term]
id: GO:0140108
name: high-affinity D-glucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:25411338]
synonym: "high-affinity glucose transmembrane transporter activity" EXACT []
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0140110
name: transcription regulator activity
namespace: molecular_function
def: "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140111
name: [choline trimethylamine-lyase]-activating enzyme activity
namespace: molecular_function
def: "Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)." [PMID:24854437]
xref: MetaCyc:RXN-16470
is_a: GO:0043364 ! glycyl-radical enzyme activating activity

[Term]
id: GO:0140112
name: extracellular vesicle biogenesis
namespace: biological_process
def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435]
synonym: "extracellular vesicle assembly" EXACT []
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0140113
name: extracellular microvesicle biogenesis
namespace: biological_process
def: "The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding." [PMID:28736435]
synonym: "extracellular microvesicle assembly" RELATED []
is_a: GO:0140112 ! extracellular vesicle biogenesis

[Term]
id: GO:0140114
name: cellular detoxification of fluoride
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]
is_a: GO:0061687 ! detoxification of inorganic compound
is_a: GO:1990748 ! cellular detoxification
relationship: part_of GO:1902618 ! cellular response to fluoride

[Term]
id: GO:0140115
name: export across plasma membrane
namespace: biological_process
def: "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]
synonym: "efflux" BROAD []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0140352 ! export from cell

[Term]
id: GO:0140116
name: fluoride export across plasma membrane
namespace: biological_process
def: "The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:27327046]
is_a: GO:0140115 ! export across plasma membrane
is_a: GO:1903424 ! fluoride transmembrane transport

[Term]
id: GO:0140121
name: Lewy body formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Lewy body." [PMID:15158159]
is_a: GO:0070841 ! inclusion body assembly

[Term]
id: GO:0140122
name: regulation of Lewy body formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Lewy body formation." [GOC:sl]
is_a: GO:0090083 ! regulation of inclusion body assembly
relationship: regulates GO:0140121 ! Lewy body formation

[Term]
id: GO:0140123
name: negative regulation of Lewy body formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation." [GOC:sl]
is_a: GO:0090084 ! negative regulation of inclusion body assembly
is_a: GO:0140122 ! regulation of Lewy body formation
relationship: negatively_regulates GO:0140121 ! Lewy body formation

[Term]
id: GO:0140124
name: positive regulation of Lewy body formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Lewy body formation." [GOC:sl]
is_a: GO:0090261 ! positive regulation of inclusion body assembly
is_a: GO:0140122 ! regulation of Lewy body formation
relationship: positively_regulates GO:0140121 ! Lewy body formation

[Term]
id: GO:0140125
name: thiamine import across plasma membrane
namespace: biological_process
def: "The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw]
is_a: GO:0071934 ! thiamine transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0140131
name: positive regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis." [PMID:19255442]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000403 ! positive regulation of lymphocyte migration
relationship: positively_regulates GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0140132
name: iron-sulfur cluster carrier activity
namespace: molecular_function
def: "Binding to an iron-sulfur cluster and delivering it to an acceptor molecule." [PMID:22966982, PMID:29051382]
is_a: GO:0140104 ! molecular carrier activity

[Term]
id: GO:0140133
name: obsolete symbiont-mediated suppression of host cytokine production
namespace: biological_process
def: "OBSOLETE. A process by which a symbiont inhibits or disrupts cytokine production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23083102]
comment: This term was obsoleted because it represents a readout.
synonym: "negative regulation by symbiont of host cytokine production" EXACT []
synonym: "suppression by symbiont of host cytokine production" EXACT []
synonym: "suppression by symbiont of host cytokine secretion" RELATED []
is_obsolete: true
consider: GO:0052027

[Term]
id: GO:0140135
name: mechanosensitive monoatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress." [GOC:ha, PMID:22343900]
synonym: "mechanically-gated cation channel activity" EXACT []
synonym: "mechanosensitive cation channel activity" BROAD []
xref: Reactome:R-HSA-9659380 "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell"
xref: Reactome:R-HSA-9663363 "Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell"
xref: Reactome:R-HSA-9855089 "PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients"
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0008381 ! mechanosensitive monoatomic ion channel activity

[Term]
id: GO:0140140
name: mitochondrial guanine nucleotide transmembrane transport
namespace: biological_process
def: "The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:14998997]
is_a: GO:1903716 ! guanine transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0140141
name: mitochondrial potassium ion transmembrane transport
namespace: biological_process
def: "The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:20197279]
is_a: GO:0071805 ! potassium ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0140142
name: nucleocytoplasmic carrier activity
namespace: molecular_function
alt_id: GO:0061717
alt_id: GO:0090631
def: "Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein." [GOC:pg]
subset: gocheck_do_not_annotate
synonym: "miRNA transporter activity" NARROW []
synonym: "nucleocytoplasmic importin/exportin activity" EXACT []
synonym: "pre-miRNA transporter activity" NARROW []
is_a: GO:0140104 ! molecular carrier activity

[Term]
id: GO:0140145
name: copper ion export from vacuole
namespace: biological_process
def: "The directed movement of copper ions out of the vacuole across the vacuolar membrane." [GOC:vw, PMID:12244050]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0140146
name: calcium ion import into vacuole
namespace: biological_process
def: "The directed movement of calcium cations into the vacuole across the vacuolar membrane." [GOC:vw, PMID:8628289]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0140147
name: zinc ion export from vacuole
namespace: biological_process
def: "The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol." [GOC:vw, PMC:PMC203372]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0140157
name: ammonium import across plasma membrane
namespace: biological_process
def: "The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:16999738]
is_a: GO:0072488 ! ammonium transmembrane transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:0140159
name: borate export across plasma membrane
namespace: biological_process
def: "The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:17459946]
is_a: GO:0035445 ! borate transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0140161
name: monocarboxylate:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in)." [GOC:ln, PMID:15322102]
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity

[Term]
id: GO:0140164
name: Golgi transport complex binding
namespace: molecular_function
def: "Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family." [GOC:ha, PMID:28100664]
synonym: "COG complex binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0140192
name: obsolete regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
comment: This term was obsoleted because it represents a GO-CAM pathway.
is_obsolete: true
replaced_by: GO:0106070

[Term]
id: GO:0140193
name: obsolete regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
comment: This term was obsoleted because it represents a GO-CAM pathway.
is_obsolete: true
replaced_by: GO:0071877

[Term]
id: GO:0140194
name: obsolete negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0003015
consider: GO:0071878

[Term]
id: GO:0140195
name: obsolete positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
comment: This term was obsoleted because it represents a GO-CAM pathway.
is_obsolete: true
replaced_by: GO:0071879

[Term]
id: GO:0140196
name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0071879 ! positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
is_a: GO:0106071 ! positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
relationship: positively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

[Term]
id: GO:0140199
name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0071878 ! negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
relationship: negatively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

[Term]
id: GO:0140200
name: obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate
namespace: biological_process
def: "OBSOLETE. An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM pathway.
is_obsolete: true
replaced_by: GO:0071880

[Term]
id: GO:0140201
name: urea import across plasma membrane
namespace: biological_process
def: "The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol." [PMID:17218313]
is_a: GO:0071918 ! urea transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0140202
name: polyamine import across plasma membrane
namespace: biological_process
def: "The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol." [PMID:17218313]
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0140203
name: spermidine import across plasma membrane
namespace: biological_process
def: "The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw]
is_a: GO:0140202 ! polyamine import across plasma membrane
is_a: GO:1903711 ! spermidine transmembrane transport

[Term]
id: GO:0140204
name: pyridoxal import across plasma membrane
namespace: biological_process
def: "The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw]
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1903090 ! pyridoxal transmembrane transport

[Term]
id: GO:0140205
name: oligopeptide import across plasma membrane
namespace: biological_process
def: "The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0140206
name: dipeptide import across plasma membrane
namespace: biological_process
def: "The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]
is_a: GO:0035442 ! dipeptide transmembrane transport
is_a: GO:0140205 ! oligopeptide import across plasma membrane

[Term]
id: GO:0140207
name: tripeptide import across plasma membrane
namespace: biological_process
def: "The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]
is_a: GO:0035443 ! tripeptide transmembrane transport
is_a: GO:0140205 ! oligopeptide import across plasma membrane

[Term]
id: GO:0140208
name: apoptotic process in response to mitochondrial fragmentation
namespace: biological_process
def: "Any apoptotic process that occurs as a result of mitochondrial fragmentation." [PMID:18940801]
synonym: "apoptosis in response to mitochondrial fragmentation" EXACT []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0140209
name: zinc ion import into endoplasmic reticulum
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum." [PMID:11886869, PMID:29529046]
comment: This term covers zinc(2+) import *across* the endoplasmic reticulum membrane through a channel or pore. It does not cover import via vesicle fusion with endoplasmic reticulum membrane, as in this case transport does not involve crossing the membrane.
synonym: "zinc ion import across endoplasmic reticulum" EXACT []
synonym: "zinc ion import into ER" EXACT []
synonym: "zinc(2+) import across endoplasmic reticulum" EXACT []
synonym: "zinc(2+) import into endoplasmic reticulum" EXACT []
is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport
is_a: GO:0062111 ! zinc ion import into organelle

[Term]
id: GO:0140210
name: protein transport along microtubule to kinetochore
namespace: biological_process
def: "Any process in which a protein is transported to the kinetochore along a microtubule." [PMID:25472718]
is_a: GO:0034501 ! protein localization to kinetochore
is_a: GO:0070199 ! establishment of protein localization to chromosome
is_a: GO:0098840 ! protein transport along microtubule

[Term]
id: GO:0140211
name: folic acid:proton symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid." [PMID:24745983]
xref: TC:2.A.1.50.1
is_a: GO:0008517 ! folic acid transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0140212
name: regulation of long-chain fatty acid import into cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239]
is_a: GO:2000191 ! regulation of fatty acid transport
relationship: regulates GO:0044539 ! long-chain fatty acid import into cell

[Term]
id: GO:0140213
name: negative regulation of long-chain fatty acid import into cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239]
is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell
is_a: GO:2000192 ! negative regulation of fatty acid transport
relationship: negatively_regulates GO:0044539 ! long-chain fatty acid import into cell

[Term]
id: GO:0140214
name: positive regulation of long-chain fatty acid import into cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239]
is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell
is_a: GO:2000193 ! positive regulation of fatty acid transport
relationship: positively_regulates GO:0044539 ! long-chain fatty acid import into cell

[Term]
id: GO:0140215
name: regulation of D-aspartate import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:0070779 ! D-aspartate import across plasma membrane

[Term]
id: GO:0140216
name: negative regulation of D-aspartate import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:0140215 ! regulation of D-aspartate import across plasma membrane
relationship: negatively_regulates GO:0070779 ! D-aspartate import across plasma membrane

[Term]
id: GO:0140217
name: positive regulation of D-aspartate import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:0140215 ! regulation of D-aspartate import across plasma membrane
relationship: positively_regulates GO:0070779 ! D-aspartate import across plasma membrane

[Term]
id: GO:0140220
name: pathogen-containing vacuole
namespace: cellular_component
def: "A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides." [PMID:10560000, PMID:26842840]
synonym: "pathogen inclusion" RELATED []
synonym: "pathogen-containing compartment" RELATED []
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0140221
name: pathogen-containing vacuole membrane
namespace: cellular_component
def: "Host-derived membrane of a pathogen-containing vacuole." [PMID:10560000, PMID:26842840]
synonym: "pathogen inclusion membrane" RELATED []
synonym: "pathogen-containing compartment membrane" EXACT []
is_a: GO:0016020 ! membrane
relationship: part_of GO:0140220 ! pathogen-containing vacuole

[Term]
id: GO:0140222
name: pathogen-containing vacuole lumen
namespace: cellular_component
def: "The enclosed volume within the sealed membrane of a pathogen-containing vacuole." [PMID:10560000, PMID:26842840]
synonym: "lumen of a pathogen-containing vacuole" EXACT []
synonym: "pathogen inclusion lumen" RELATED []
synonym: "pathogen-containing compartment lumen" EXACT []
synonym: "pathogen-containing vacuolar lumen" EXACT []
is_a: GO:0031974 ! membrane-enclosed lumen
relationship: part_of GO:0140220 ! pathogen-containing vacuole

[Term]
id: GO:0140223
name: general transcription initiation factor activity
namespace: molecular_function
def: "A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]
comment: Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "basal transcription factor activity" EXACT []
synonym: "general transcription factor activity" EXACT []
synonym: "GTF activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140224
name: SLAC complex
namespace: cellular_component
def: "A protein complex that regulates Arp2/3 complex-mediated actin nucleation." [GOC:lnp, PMID:22973053]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0140225
name: DNA topoisomerase III-beta-TDRD3 complex
namespace: cellular_component
def: "A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities." [GOC:lnp, PMID:23912945, PMID:28176834]
synonym: "Top3-beta-TDRD3 complex" EXACT [GOC:krc]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0140226
name: RNA topoisomerase activity
namespace: molecular_function
def: "Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA." [GOC:lnp, PMID:23912945, PMID:27257063]
is_a: GO:0016853 ! isomerase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0140227
name: serotonin-gated cation-selective signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25392484, PMID:27764665]
synonym: "5-HT-gated cation-selective signaling pathway" EXACT []
synonym: "5-HT-gated cation-selective signalling pathway" EXACT []
synonym: "5-hydroxytryptamine-gated cation-selective signaling pathway" EXACT []
synonym: "5-hydroxytryptamine-gated cation-selective signalling pathway" EXACT []
synonym: "serotonin-gated cation-selective signalling pathway" EXACT []
is_a: GO:0007210 ! serotonin receptor signaling pathway
is_a: GO:1990806 ! ligand-gated ion channel signaling pathway

[Term]
id: GO:0140231
name: anterograde axonal transport of neurotransmitter receptor complex
namespace: biological_process
def: "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons." [PMID:28680963]
subset: goslim_synapse
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0099637 ! neurotransmitter receptor transport
is_a: GO:0099641 ! anterograde axonal protein transport

[Term]
id: GO:0140232
name: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential." [PMID:21358644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
synonym: "intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential" EXACT []
is_a: GO:0005222 ! intracellularly cAMP-activated cation channel activity

[Term]
id: GO:0140233
name: intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential." [GOC:pvn]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
synonym: "intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential" EXACT []
is_a: GO:0005222 ! intracellularly cAMP-activated cation channel activity

[Term]
id: GO:0140235
name: RNA polyadenylation at postsynapse
namespace: biological_process
def: "A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse." [PMID:22727665]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0140236
name: translation at presynapse
namespace: biological_process
def: "Translation that occurs at the presynapse." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse

[Term]
id: GO:0140237
name: translation at presynapse, modulating chemical synaptic transmission
namespace: biological_process
def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140236 ! translation at presynapse
relationship: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0140238
name: presynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006897 ! endocytosis
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse

[Term]
id: GO:0140239
name: postsynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006897 ! endocytosis
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse

[Term]
id: GO:0140240
name: perforant pathway to dendrate granule cell synapse
namespace: cellular_component
def: "A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus." [PMID:22727665, PMID:29199135]
subset: goslim_synapse
synonym: "perforant pathway to DG granule cell synapse" EXACT []
is_a: GO:0045202 ! synapse

[Term]
id: GO:0140241
name: translation at synapse
namespace: biological_process
def: "Translation that occurs at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006412 ! translation

[Term]
id: GO:0140242
name: translation at postsynapse
namespace: biological_process
def: "Translation that occurs at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse

[Term]
id: GO:0140243
name: regulation of translation at synapse
namespace: biological_process
def: "Any process that regulates translation occurring at the synapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0140244
name: regulation of translation at presynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse

[Term]
id: GO:0140245
name: regulation of translation at postsynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse

[Term]
id: GO:0140246
name: protein catabolic process at synapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0030163 ! protein catabolic process

[Term]
id: GO:0140247
name: protein catabolic process at presynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse

[Term]
id: GO:0140249
name: protein catabolic process at postsynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse

[Term]
id: GO:0140250
name: regulation protein catabolic process at synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0009894 ! regulation of catabolic process

[Term]
id: GO:0140251
name: regulation protein catabolic process at presynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse

[Term]
id: GO:0140252
name: regulation protein catabolic process at postsynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse

[Term]
id: GO:0140253
name: cell-cell fusion
namespace: biological_process
def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion]
synonym: "cell cell fusion" EXACT []
synonym: "cell fusion" BROAD []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0140255
name: regulation of cellular response to phosphate starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation." [PMID:29414789]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0016036 ! cellular response to phosphate starvation

[Term]
id: GO:0140256
name: negative regulation of cellular response to phosphate starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation." [PMID:29414789]
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0140255 ! regulation of cellular response to phosphate starvation
relationship: negatively_regulates GO:0016036 ! cellular response to phosphate starvation

[Term]
id: GO:0140259
name: PRC1 complex binding
namespace: molecular_function
def: "Binding to a PRC1 complex." [PMID:15280237]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0140260
name: mitochondrial proton-transporting ATP synthase complex binding
namespace: molecular_function
def: "Binding to a mitochondrial proton-transporting ATP synthase complex." [PMID:12110673]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0140261
name: BCOR complex
namespace: cellular_component
def: "A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10." [PMID:16943429, PMID:22325352, PMID:24515802]
synonym: "BCL6 corepressor (BCOR) complex" EXACT []
synonym: "BCOR/BCORL1 complex" EXACT []
synonym: "non-canonical BCOR-PRC1.1 complex" EXACT []
synonym: "non-canonical PRC1-BCOR complex" EXACT []
synonym: "PRC1.1 complex" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0140262
name: mRNA cap binding complex binding
namespace: molecular_function
def: "Binding to a mRNA cap binding complex." [PMID:16938833]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0140266
name: Woronin body
namespace: cellular_component
def: "Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes." [PMID:12640443, PMID:15155882, PMID:18227279, PMID:20707002, PMID:23882222]
is_a: GO:0042579 ! microbody

[Term]
id: GO:0140267
name: symbiont entry into host cell via permeabilization of host membrane
namespace: biological_process
def: "The entry of a symbiont into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration symbiont protein. This process mediates the entry of some non-enveloped virus into host cells, and results in the release of the virus contents into the host cell cytoplasm." [PMID:20427561, PMID:25055856, VZ:985]
synonym: "viral entry via permeabilization of host membrane" NARROW []
xref: VZ:985 "Viral penetration via permeabilization of host membrane"
is_a: GO:0141171 ! symbiont-mediated perturbation of host membrane
relationship: part_of GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:0140268
name: endoplasmic reticulum-plasma membrane contact site
namespace: cellular_component
def: "A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]
synonym: "endoplasmic reticulum-plasma membrane contact junction" EXACT []
synonym: "EPCS" EXACT []
synonym: "ER-plasma membrane contact site" EXACT []
synonym: "ER-PM contact site" EXACT []
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0140270
name: gluconate import across plasma membrane
namespace: biological_process
def: "The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857]
is_a: GO:0035429 ! gluconate transmembrane transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0140271
name: hexose import across plasma membrane
namespace: biological_process
def: "The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857]
is_a: GO:0008645 ! hexose transmembrane transport
is_a: GO:0098704 ! carbohydrate import across plasma membrane

[Term]
id: GO:0140272
name: exogenous protein binding
namespace: molecular_function
def: "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein." [PMID:28861068]
comment: Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0140273
name: repair of mitotic kinetochore microtubule attachment defect
namespace: biological_process
def: "The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected." [PMID:15525536]
synonym: "correction of mitotic kinetochore microtubule attachment defects" EXACT []
synonym: "repair of mitotic kinetochore microtubule attachment defects" EXACT []
is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007080 ! mitotic metaphase chromosome alignment

[Term]
id: GO:0140274
name: repair of kinetochore microtubule attachment defect
namespace: biological_process
def: "The cell cycle process where kinetochore microtubule attachment defects are corrected." [PMID:15525536]
synonym: "correction of kinetochore microtubule attachment defects" EXACT []
synonym: "repair of kinetochore microtubule attachment defects" EXACT []
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0140275
name: MIB complex
namespace: cellular_component
def: "A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1." [PMID:26477565]
synonym: "mitochondrial intermembrane space bridging complex" EXACT []
synonym: "mitofilin complex" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:0140276
name: obsolete pericentric heterochromatin maintenance
namespace: biological_process
alt_id: GO:1902368
def: "OBSOLETE. Any heterochromatin maintenance that is involved in chromatin silencing at or near a centromere." [GOC:TermGenie, GOC:vw, PMID:21289066]
comment: This term was obsoleted because it represents a phenotype.
synonym: "heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region" RELATED []
synonym: "heterochromatin maintenance involved in chromatin silencing at centromeric outer repeats" EXACT [GOC:vw]
synonym: "heterochromatin maintenance involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:0140278
name: mitotic division septum assembly
namespace: biological_process
def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material." [PMID:22786806]
is_a: GO:0000917 ! division septum assembly
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:0140279
name: regulation of mitotic division septum assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806]
synonym: "regulation of division septum formation involved in mitotic cell cycle" EXACT []
synonym: "regulation of formation of division septum involved in mitotic cell cycle" EXACT []
synonym: "regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0032955 ! regulation of division septum assembly
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
relationship: regulates GO:0140278 ! mitotic division septum assembly

[Term]
id: GO:0140280
name: negative regulation of mitotic division septum assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806]
synonym: "down regulation of division septum formation involved in mitotic cell cycle" EXACT []
synonym: "down regulation of formation of division septum involved in mitotic cell cycle" EXACT []
synonym: "down regulation of mitotic division septum assembly" EXACT []
synonym: "down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT []
synonym: "down regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT []
synonym: "down-regulation of division septum formation involved in mitotic cell cycle" EXACT []
synonym: "down-regulation of formation of division septum involved in mitotic cell cycle" EXACT []
synonym: "down-regulation of mitotic division septum assembly" EXACT []
synonym: "down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of division septum formation involved in mitotic cell cycle" EXACT []
synonym: "downregulation of formation of division septum involved in mitotic cell cycle" EXACT []
synonym: "downregulation of mitotic division septum assembly" EXACT []
synonym: "downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "inhibition of division septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of formation of division septum involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic division septum assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "inhibition of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of division septum formation involved in mitotic cell cycle" EXACT []
synonym: "negative regulation of formation of division septum involved in mitotic cell cycle" EXACT []
synonym: "negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0010974 ! negative regulation of division septum assembly
is_a: GO:0140279 ! regulation of mitotic division septum assembly
is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process
relationship: negatively_regulates GO:0140278 ! mitotic division septum assembly

[Term]
id: GO:0140281
name: positive regulation of mitotic division septum assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806]
synonym: "activation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "activation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "activation of mitotic division septum assembly" EXACT [GOC:TermGenie]
synonym: "activation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "activation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic division septum assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic division septum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0010973 ! positive regulation of division septum assembly
is_a: GO:0140279 ! regulation of mitotic division septum assembly
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
relationship: positively_regulates GO:0140278 ! mitotic division septum assembly

[Term]
id: GO:0140282
name: carbon-nitrogen ligase activity on lipid II
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate." [PMID:22291598, PMID:30093673, PMID:30154570, RHEA:57928]
synonym: "L-glutamate--lipid II transaminase activity" EXACT []
synonym: "undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity" EXACT []
xref: EC:6.3.5.13
xref: RHEA:57928
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0140284
name: endoplasmic reticulum-endosome membrane contact site
namespace: cellular_component
def: "A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460]
synonym: "ER-endosome membrane contact site" EXACT []
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0140285
name: endosome fission
namespace: biological_process
def: "The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane." [PMID:25416943, PMID:30220460]
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0140288
name: GBAF complex
namespace: cellular_component
def: "A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM." [PMID:29374058]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0140289
name: obsolete protein mono-ADP-ribosylation
namespace: biological_process
def: "OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids." [PMID:25043379]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0003950

[Term]
id: GO:0140290
name: peptidyl-serine ADP-deribosylation
namespace: biological_process
def: "The removal of ADP-ribose from ADP-ribosylserine." [PMID:28650317, PMID:29234005]
is_a: GO:0051725 ! protein de-ADP-ribosylation

[Term]
id: GO:0140291
name: peptidyl-glutamate ADP-deribosylation
namespace: biological_process
def: "The removal of ADP-ribose from ADP-ribosylglutamate." [PMID:23481255]
is_a: GO:0051725 ! protein de-ADP-ribosylation

[Term]
id: GO:0140292
name: ADP-ribosylserine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose." [PMID:28650317, PMID:29234005, RHEA:58256]
xref: RHEA:58256
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140293
name: ADP-ribosylglutamate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose." [PMID:23481255]
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140294
name: NAD DNA ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA." [PMID:27471034, PMID:29361132, PMID:29520010]
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0140295
name: pathogen-derived receptor ligand activity
namespace: molecular_function
def: "The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity." [PMID:20601497]
comment: Note that this term is meant to annotate effectors for which the evolved activity is to act as a ligand to activate (for necrotrophs) or suppress (for biotrophs) the host immune system. It should not be used to annotate PAMPs (pathogen-associated molecular pattern molecules) or similar types of microbial proteins recognized by the host innate immune system (for example, PAMPs are recognized by toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals). PAMPs activate innate immune responses, protecting the host from infection, but this is not the molecular function of PAMPs; those usually form the structure of the bacterial cell wall.
synonym: "host-selective toxin" RELATED []
synonym: "innate receptor ligand activity" RELATED []
synonym: "necrotrophic effector" RELATED []
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0140296
name: general transcription initiation factor binding
namespace: molecular_function
def: "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0140297
name: DNA-binding transcription factor binding
namespace: molecular_function
alt_id: GO:0001107
alt_id: GO:0033613
alt_id: GO:0070491
def: "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]
synonym: "activating transcription factor binding" RELATED []
synonym: "repressing transcription factor binding" RELATED []
synonym: "transcription activator binding" RELATED []
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0140298
name: endocytic iron import into cell
namespace: biological_process
def: "Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis." [PMID:23092063]
synonym: "iron import into cell by endocytosis" EXACT []
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0033212 ! iron import into cell

[Term]
id: GO:0140299
name: molecular sensor activity
namespace: molecular_function
def: "Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule." [PMID:26328879]
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "small molecular sensor activity" EXACT []
synonym: "small molecule sensing activity" EXACT []
synonym: "small molecule sensor activity" NARROW []
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0140300
name: serine import into mitochondrion
namespace: biological_process
def: "The process in which serine is transported from the cytosol into the mitochondrial matrix." [PMID:30442778]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0032329 ! serine transport
is_a: GO:0170036 ! import into the mitochondrion
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0140301
name: pollen-stigma interaction
namespace: biological_process
def: "The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae." [PMID:27899537]
is_a: GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0140302
name: pollen-style interaction
namespace: biological_process
def: "The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte." [PMID:27899537]
is_a: GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0140303
name: intramembrane lipid transporter activity
namespace: molecular_function
def: "Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]
synonym: "flippase activity" RELATED []
synonym: "translocase activity" BROAD []
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0140306
name: lipoprotein releasing activity
namespace: molecular_function
def: "The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex." [PMID:10783239, PMID:21670534]
is_a: GO:0140318 ! protein transporter activity

[Term]
id: GO:0140311
name: protein sequestering activity
namespace: molecular_function
def: "Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:1493333]
is_a: GO:0140313 ! molecular sequestering activity

[Term]
id: GO:0140312
name: cargo adaptor activity
namespace: molecular_function
alt_id: GO:0098748
def: "Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]
synonym: "endocytic adaptor activity" NARROW []
xref: Reactome:R-HSA-203565 "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP"
xref: Reactome:R-HSA-203662 "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2"
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0140313
name: molecular sequestering activity
namespace: molecular_function
def: "Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:13130076]
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
xref: Reactome:R-HSA-203553 "eNOS binds NOSIP"
xref: Reactome:R-HSA-203680 "eNOS:NOSIP translocation from caveolae to intracellular compartments"
xref: Reactome:R-HSA-3245898 "TCN1 binds correnoids in the circulation"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140314
name: calcium ion sequestering activity
namespace: molecular_function
def: "Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:13130076]
is_a: GO:0140487 ! metal ion sequestering activity

[Term]
id: GO:0140315
name: iron ion sequestering activity
namespace: molecular_function
def: "Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:27780864]
is_a: GO:0140487 ! metal ion sequestering activity

[Term]
id: GO:0140316
name: obsolete vesicular transport adaptor activity
namespace: molecular_function
def: "OBSOLETE. Binding directly to sorting signals in the cytosolic tails of transmembrane cargos (or transmembrane cargo receptors serving as recognition interfaces for lumenal cargos), to concentrate them into vesicles or tubules for transport via intracellular vesicular transport or the secretory pathway." [PMID:25795254]
comment: Thi sterm was obsoleted because it represented an unnecessary grouping class.
is_obsolete: true

[Term]
id: GO:0140317
name: export across cell outer membrane
namespace: biological_process
def: "The directed movement of a substance across the outer membrane in cells with two membranes." [PMID:15968039]
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0140318
name: protein transporter activity
namespace: molecular_function
def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]
comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.
synonym: "protein carrier activity" RELATED []
synonym: "protein transport chaperone" RELATED []
xref: Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome"
xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network"
xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane"
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0140319
name: receptor decoy activity
namespace: molecular_function
alt_id: GO:0005040
def: "Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor." [Wikipedia:Decoy_receptors]
synonym: "decoy death receptor activity" NARROW []
synonym: "decoy receptor" EXACT []
is_a: GO:0140313 ! molecular sequestering activity

[Term]
id: GO:0140320
name: PAMP receptor decoy activity
namespace: molecular_function
def: "Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response." [PMID:20724636]
synonym: "pathogen-associated molecular pattern receptor decoy activity" EXACT []
synonym: "pattern recognition receptor decoy activity" EXACT []
is_a: GO:0140319 ! receptor decoy activity

[Term]
id: GO:0140321
name: symbiont-mediated suppression of host autophagy
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pg]
synonym: "negative regulation by symbiont of host autophagy" EXACT []
synonym: "suppression of host autophagy" EXACT []
is_a: GO:0075071 ! symbiont-mediated perturbation of host autophagy

[Term]
id: GO:0140323
name: obsolete solute:monoatomic anion antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(in) + solute(out) = anion(out) + solute(in)." [GOC:pg]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "solute:anion antiporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0140325
name: negative regulation of protein localization to medial cortex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex." [PMID:30853434]
is_a: GO:0106011 ! regulation of protein localization to medial cortex
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
is_a: GO:1904777 ! negative regulation of protein localization to cell cortex
relationship: negatively_regulates GO:0071574 ! protein localization to medial cortex

[Term]
id: GO:0140326
name: ATPase-coupled intramembrane lipid transporter activity
namespace: molecular_function
alt_id: GO:0004012
alt_id: GO:0008557
def: "Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]
synonym: "aminophospholipid-transporting ATPase" RELATED []
synonym: "ATPase-coupled phospholipid transporter activity" RELATED []
synonym: "ATPase-dependent phospholipid transporter activity" RELATED []
synonym: "phospholipid flippase activity" NARROW []
synonym: "phospholipid translocating ATPase activity" RELATED []
synonym: "phospholipid-translocating ATPase activity" RELATED []
synonym: "phospholipid-transporting ATPase activity" RELATED [EC:7.6.2.1]
xref: EC:7.6.2.1
xref: MetaCyc:3.6.3.1-RXN
xref: Reactome:R-HSA-939763 "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane"
xref: Reactome:R-HSA-947591 "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane"
is_a: GO:0140303 ! intramembrane lipid transporter activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0140327
name: flippase activity
namespace: molecular_function
def: "Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase]
comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaflet of a membrane).
synonym: "flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity

[Term]
id: GO:0140328
name: floppase activity
namespace: molecular_function
def: "Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase]
comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the cytosolic to the exoplasmic leaflet of a membrane).
synonym: "floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity

[Term]
id: GO:0140329
name: lysophospholipid translocation
namespace: biological_process
def: "The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [PMID:15661733]
is_a: GO:0045332 ! phospholipid translocation
is_a: GO:0051977 ! lysophospholipid transport

[Term]
id: GO:0140330
name: xenobiotic detoxification by transmembrane export across the cell outer membrane
namespace: biological_process
def: "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane." [PMID:11948170]
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0140317 ! export across cell outer membrane
relationship: part_of GO:0098754 ! detoxification

[Term]
id: GO:0140331
name: aminophospholipid translocation
namespace: biological_process
def: "The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:pg]
is_a: GO:0015917 ! aminophospholipid transport
is_a: GO:0045332 ! phospholipid translocation

[Term]
id: GO:0140332
name: lipopolysaccharide transfer activity
namespace: molecular_function
def: "Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:24639492]
synonym: "intermembrane lipopolysaccharide transfer activity" EXACT []
synonym: "intermembrane lipopolysaccharide transporter activity" EXACT []
synonym: "intermembrane LPS transporter activity" EXACT []
synonym: "lipopolysaccharide carrier activity" EXACT []
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0140333
name: glycerophospholipid flippase activity
namespace: molecular_function
def: "Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:26212235]
synonym: "glycerophospholipid flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0140327 ! flippase activity

[Term]
id: GO:0140334
name: lipopolysaccharide localization to cell outer membrane
namespace: biological_process
def: "A process in which a lipopolysaccharide is transported to the cell outer membrane." [PMID:24639492]
synonym: "LPS localization to cell outer membrane" EXACT []
is_a: GO:0010876 ! lipid localization
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0140337
name: diacylglyceride transfer activity
namespace: molecular_function
def: "Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017]
synonym: "diacylglyceride carrier activity" EXACT []
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0140338
name: sphingomyelin transfer activity
namespace: molecular_function
alt_id: GO:0010175
def: "Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:9132017]
synonym: "sphingomyelin carrier activity" EXACT []
synonym: "sphingosine transmembrane transporter activity" BROAD []
is_a: GO:0120014 ! phospholipid transfer activity
is_a: GO:0120016 ! sphingolipid transfer activity

[Term]
id: GO:0140339
name: phosphatidylglycerol transfer activity
namespace: molecular_function
def: "Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017]
synonym: "phosphatidylglycerol carrier activity" EXACT []
is_a: GO:0120014 ! phospholipid transfer activity

[Term]
id: GO:0140340
name: cerebroside transfer activity
namespace: molecular_function
def: "Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017]
synonym: "cerebroside carrier activity" EXACT []
is_a: GO:0017089 ! glycolipid transfer activity
is_a: GO:0120017 ! ceramide transfer activity

[Term]
id: GO:0140341
name: phosphatidylethanolamine floppase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:10029989]
synonym: "phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaflet)" EXACT []
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0140328 ! floppase activity

[Term]
id: GO:0140343
name: phosphatidylserine transfer activity
namespace: molecular_function
def: "Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:26206935]
synonym: "intermembrane phosphatidylserine carrier activity" NARROW []
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0140344
name: triglyceride transfer activity
namespace: molecular_function
def: "Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location." [PMID:23475612]
synonym: "triglyceride carrier activity" EXACT []
is_a: GO:0120013 ! lipid transfer activity

[Term]
id: GO:0140345
name: phosphatidylcholine flippase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:11870854]
synonym: "phosphatidylcholine flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
is_a: GO:0008525 ! phosphatidylcholine transporter activity
is_a: GO:0140333 ! glycerophospholipid flippase activity

[Term]
id: GO:0140346
name: phosphatidylserine flippase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:11870854]
synonym: "phosphatidylserine flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
is_a: GO:0015247 ! aminophospholipid flippase activity
is_a: GO:0140333 ! glycerophospholipid flippase activity

[Term]
id: GO:0140347
name: N-retinylidene-phosphatidylethanolamine flippase activity
namespace: molecular_function
def: "Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:10412977]
synonym: "N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
is_a: GO:0140333 ! glycerophospholipid flippase activity

[Term]
id: GO:0140348
name: lysophosphatidylcholine flippase activity
namespace: molecular_function
def: "Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:26945070]
synonym: "lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
is_a: GO:0140333 ! glycerophospholipid flippase activity

[Term]
id: GO:0140351
name: glycosylceramide flippase activity
namespace: molecular_function
def: "Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar." [PMID:30530492]
synonym: "galactocerebroside flippase activity" NARROW []
synonym: "galactosylceramide flippase activity" NARROW []
synonym: "glucosylceramide flippase activity" NARROW []
synonym: "glycoceramide flippase activity" EXACT []
synonym: "glycosylceramide flippase activity (exoplasmic to cytosolic leaflet)" EXACT []
is_a: GO:0046624 ! sphingolipid transporter activity
is_a: GO:0140327 ! flippase activity

[Term]
id: GO:0140352
name: export from cell
namespace: biological_process
def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg]
synonym: "efflux" BROAD []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0140353
name: lipid export from cell
namespace: biological_process
def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg]
synonym: "lipid efflux" BROAD []
is_a: GO:0006869 ! lipid transport
is_a: GO:0140352 ! export from cell

[Term]
id: GO:0140354
name: lipid import into cell
namespace: biological_process
def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg]
synonym: "lipid uptake" BROAD []
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0140355
name: cargo receptor ligand activity
namespace: molecular_function
def: "The activity of a gene product that interacts with a cargo receptor and initiates endocytosis." [PMID:15797858]
synonym: "cargo" RELATED []
xref: Reactome:R-HSA-3000074 "TCN2 binds RCbl in the circulation"
xref: Reactome:R-HSA-3000120 "CBLIF binds RCbl"
xref: Reactome:R-HSA-3132759 "TCN1 binds RCbl"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0140357
name: heme export from vacuole to cytoplasm
namespace: biological_process
def: "The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol." [PMID:28193844]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0035351 ! heme transmembrane transport

[Term]
id: GO:0140358
name: P-type transmembrane transporter activity
namespace: molecular_function
def: "Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]
synonym: "E1-E2 ATPase" EXACT [Wikipedia:P-type_ATPase]
synonym: "P-type ATPase" EXACT [Wikipedia:P-type_ATPase]
xref: TC:3.A.3
xref: Wikipedia:P-type_ATPase
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0140359
name: ABC-type transporter activity
namespace: molecular_function
def: "Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]
synonym: "ABC transporter" EXACT []
synonym: "ABC-type efflux permease activity" EXACT []
synonym: "ABC-type efflux porter activity" EXACT []
synonym: "ABC-type transmembrane transporter activity" EXACT []
synonym: "ABC-type uptake permease activity" EXACT []
synonym: "ATP binding cassette transporter" EXACT []
synonym: "ATP-binding cassette (ABC) transporter activity" EXACT []
synonym: "ATP-binding cassette transporter" EXACT []
xref: Reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1"
xref: Reactome:R-HSA-429157 "ABCC4 accumulation of dense granule contents"
xref: Reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol"
xref: Reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner"
xref: Reactome:R-HSA-9661405 "ABCC1 transports BIL from cytosol to extracellular region (blood)"
xref: Reactome:R-HSA-9750656 "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells"
xref: TC:3.A.1
xref: Wikipedia:ATP-binding_cassette_transporter
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity

[Term]
id: GO:0140360
name: cyclic-GMP-AMP transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other." [PMID:31126740]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0140361
name: cyclic-GMP-AMP transmembrane import across plasma membrane
namespace: biological_process
def: "The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol." [PMID:31126740]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0070729 ! cyclic nucleotide transport
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1903790 ! guanine nucleotide transmembrane transport

[Term]
id: GO:0140363
name: TIS granule
namespace: cellular_component
def: "A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER)." [PMID:30449617, PMID:30479375, Wikipedia:TIGER_domain]
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0140364
name: GW body
namespace: cellular_component
def: "A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs." [PMID:16418578, PMID:26930655, PMID:29576456]
synonym: "GW-body" EXACT []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0140365
name: RNP body
namespace: cellular_component
def: "A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules." [PMID:30197298]
synonym: "BR-body" EXACT []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0140366
name: galectin lattice
namespace: cellular_component
def: "A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids." [PMID:19021578, PMID:26092931, PMID:28893908, PMID:30951647]
is_a: GO:0098635 ! protein complex involved in cell-cell adhesion

[Term]
id: GO:0140367
name: antibacterial innate immune response
namespace: biological_process
def: "An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:16177355, PMID:23006328]
is_a: GO:0042742 ! defense response to bacterium
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0140368
name: decoy receptor complex
namespace: cellular_component
def: "A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound." [GOC:bhm, PMID:30621730, PMID:9168977]
synonym: "osteoclastogenesis inhibitory factor" NARROW []
synonym: "osteoprotegerin complex" NARROW []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0140372
name: obsolete histone H3 ubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of one or more ubiquitin groups." [GOC:mah, PMID:31468675]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 ubiquitylation" EXACT []
is_obsolete: true

[Term]
id: GO:0140373
name: obsolete histone H3-K14 ubiquitination
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone." [GOC:mah, PMID:31468675]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3 ubiquitination at K14" EXACT []
synonym: "histone H3-K14 ubiquitylation" EXACT []
synonym: "histone H3K14 ubiquitination" EXACT []
is_obsolete: true
consider: GO:0140851

[Term]
id: GO:0140374
name: antiviral innate immune response
namespace: biological_process
def: "A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:31006531]
is_a: GO:0045087 ! innate immune response
is_a: GO:0051607 ! defense response to virus

[Term]
id: GO:0140375
name: immune receptor activity
namespace: molecular_function
def: "Receiving a signal and transmitting it in a cell to initiate an immune response." [PMID:31415752, Wikipedia:Immune_receptor]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0140376
name: innate immune receptor activity
namespace: molecular_function
def: "Receiving a signal and transmitting it in a cell to initiate an innate immune response." [PMID:28921463, PMID:31415752]
is_a: GO:0140375 ! immune receptor activity

[Term]
id: GO:0140380
name: psilocybin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product." [PMID:28763571]
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0140381
name: 4-hydroxytryptamine 4-phosphate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) = 2 S-adenosyl-L-homocysteine + psilocybin." [PMID:28763571]
synonym: "norbaeocystin methyltransferase" EXACT []
synonym: "psilocybin synthase" EXACT []
xref: EC:2.1.1.345
xref: RHEA:55568
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0140382
name: tryptamine 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O." [PMID:28763571]
xref: EC:1.14.99.59
xref: RHEA:15865
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0140383
name: 4-hydroxytryptamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+." [PMID:28763571]
xref: EC:2.7.1.222
xref: RHEA:55564
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0140384
name: metacyclogenesis
namespace: biological_process
def: "The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania." [PMID:12152483, PMID:21514274, PMID:2659372, PMID:29091711, PMID:29409544]
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0140393
name: norsolorinic acid ketoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH." [PMID:10584035, PMID:8368836, RHEA:35447]
xref: EC:1.1.1.349
xref: KEGG_REACTION:R10309
xref: MetaCyc:RXN-9480
xref: RHEA:35447
is_a: GO:0045703 ! ketoreductase activity

[Term]
id: GO:0140394
name: ABC-type azole transporter activity
namespace: molecular_function
def: "Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out)." [PMID:31501141, RHEA:33503]
synonym: "ATPase-coupled azole transmembrane transporter activity" RELATED []
synonym: "azole ABC transporter activity" EXACT []
xref: RHEA:33503
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:0140395
name: averantin hydroxylase activity
namespace: molecular_function
def: "Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis." [EC:1.14.14.116, PMID:8368836]
xref: EC:1.14.14.116
xref: MetaCyc:RXN-9482
xref: RHEA:35575
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0140396
name: 5'-hydroxyaverantin dehydrogenase activity
namespace: molecular_function
def: "Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH." [EC:1.1.1.352, PMID:14602595]
xref: EC:1.1.1.352
xref: RHEA:35475
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0140397
name: versiconal hemiacetal acetate esterase activity
namespace: molecular_function
def: "Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate." [EC:3.1.1.94, PMID:15006741, PMID:15932995, PMID:8368837]
xref: EC:3.1.1.94
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0140398
name: versicolorin B desaturase activity
namespace: molecular_function
def: "Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus." [PMID:15006741, PMID:8368837]
xref: EC:1.14.19.n5
xref: KEGG_REACTION:R10479
xref: MetaCyc:RXN-9495
xref: RHEA:35743
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0140399
name: aflatoxin B synthase activity
namespace: molecular_function
def: "Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 = aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2)." [EC:1.14.14.117]
xref: EC:1.14.14.117
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0140403
name: effector-mediated suppression of host innate immune response
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214, PMID:30584105]
synonym: "effector dependent suppression of host immune innate response by symbiont" EXACT []
synonym: "effector triggered suppression of host immune innate response by symbiont" EXACT []
synonym: "effector-dependent suppression of host immune innate response by symbiont" EXACT []
synonym: "effector-mediated suppression of host immune innate response by symbiont" EXACT []
synonym: "effector-mediated suppression of host innate immune response by symbiont" EXACT []
synonym: "effector-mediated suppression of host innate immunity" EXACT []
synonym: "effector-triggered suppression of host immune innate response by symbiont" EXACT []
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response
is_a: GO:0140404 ! effector-mediated perturbation of host innate immune response by symbiont
is_a: GO:0140590 ! effector-mediated suppression of host defense response

[Term]
id: GO:0140404
name: effector-mediated perturbation of host innate immune response by symbiont
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214]
synonym: "effector mediated modulation of host immune response by symbiont" EXACT []
synonym: "effector triggered modulation of host immune response by symbiont" EXACT []
synonym: "effector-dependent modulation of host immune response by symbiont" EXACT []
synonym: "effector-mediated modulation of host immunity" EXACT []
synonym: "effector-mediated modulation of host innate immune response by symbiont" EXACT []
synonym: "effector-triggered modulation of host immune response by symbiont" EXACT []
is_a: GO:0052167 ! symbiont-mediated perturbation of host innate immune response
is_a: GO:0140415 ! effector-mediated perturbation of host defenses by symbiont

[Term]
id: GO:0140405
name: spindle pole body-led chromosome movement during mitotic interphase
namespace: biological_process
def: "A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase." [PMID:31483748]
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0051303 ! establishment of chromosome localization

[Term]
id: GO:0140406
name: L-alanine export across the plasma membrane
namespace: biological_process
def: "The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region." [PMID:26073055, PMID:31591285]
is_a: GO:0032973 ! amino acid export across plasma membrane
is_a: GO:1904557 ! L-alanine transmembrane transport

[Term]
id: GO:0140407
name: L-alanine:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)." [PMID:26073055, PMID:31591285]
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015180 ! L-alanine transmembrane transporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0140408
name: regulation of mRNA alternative polyadenylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation." [PMID:29507755]
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
relationship: regulates GO:0110104 ! mRNA alternative polyadenylation

[Term]
id: GO:0140409
name: positive regulation of mRNA alternative polyadenylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation." [PMID:29507755]
is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing
is_a: GO:0140408 ! regulation of mRNA alternative polyadenylation
relationship: positively_regulates GO:0110104 ! mRNA alternative polyadenylation

[Term]
id: GO:0140410
name: monoatomic cation:bicarbonate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]
synonym: "monoatomic cation:hydrogencarbonate symporter activity" EXACT []
synonym: "solute:bicarbonate symporter activity" BROAD []
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity
is_a: GO:0015294 ! solute:monoatomic cation symporter activity

[Term]
id: GO:0140412
name: zinc:bicarbonate symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in)." [PMID:27166256]
synonym: "zinc:hydrogencarbonate symporter activity" EXACT []
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0140410 ! monoatomic cation:bicarbonate symporter activity

[Term]
id: GO:0140413
name: zinc:bicarbonate:selenite symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out)." [PMID:27166256]
synonym: "zinc:hydrogencarbonate:selenate symporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0140412 ! zinc:bicarbonate symporter activity

[Term]
id: GO:0140414
name: phosphopantetheine-dependent carrier activity
namespace: molecular_function
def: "Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate." [PMID:17502372]
synonym: "carrier protein activity" EXACT []
is_a: GO:0140104 ! molecular carrier activity

[Term]
id: GO:0140415
name: effector-mediated perturbation of host defenses by symbiont
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:30610168]
synonym: "effector-mediated modulation of host defenses by symbiont" EXACT []
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response
is_a: GO:0052200 ! symbiont-mediated response to host defenses
is_a: GO:0140418 ! effector-mediated perturbation of host process by symbiont

[Term]
id: GO:0140416
name: transcription regulator inhibitor activity
namespace: molecular_function
def: "A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification." [PMID:10652346]
comment: Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA.
synonym: "DNA-binding transcription factor inhibitor activity" NARROW []
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0140417
name: intracellularly ATP-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts." [PMID:22736763]
synonym: "ATP-sensitive calcium-release channel activity" RELATED []
is_a: GO:0015278 ! intracellularly gated calcium channel activity

[Term]
id: GO:0140418
name: effector-mediated perturbation of host process by symbiont
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214]
synonym: "effector mediated modulation of host process by symbiont" EXACT []
synonym: "effector triggered modulation of host process by symbiont" EXACT []
synonym: "effector-dependent modulation of host process by symbiont" EXACT []
synonym: "effector-mediated modulation of host process by symbiont" EXACT []
is_a: GO:0044003 ! symbiont-mediated perturbation of host process

[Term]
id: GO:0140420
name: heme import into cell
namespace: biological_process
def: "The directed movement of a heme from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [PMID:28193844]
synonym: "heme assimilation" BROAD []
is_a: GO:0015886 ! heme transport
is_a: GO:0033212 ! iron import into cell

[Term]
id: GO:0140421
name: endocytic heme import into cell
namespace: biological_process
def: "The directed movement into cell of externally available heme by receptor-mediated endocytosis." [PMID:28193844]
synonym: "heme assimilation" BROAD []
is_a: GO:0140298 ! endocytic iron import into cell
is_a: GO:0140420 ! heme import into cell

[Term]
id: GO:0140423
name: effector-mediated suppression of host pattern-triggered immunity signaling
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants." [PMID:30584105]
synonym: "effector-mediated suppression of host pattern recognition receptor signaling" BROAD []
synonym: "effector-mediated suppression of host PRR signaling" BROAD []
synonym: "effector-mediated suppression of host PRR signalling" BROAD []
synonym: "effector-mediated suppression of pattern-triggered immunity signaling" EXACT []
synonym: "effector-mediated suppression of PTI signalling" EXACT []
is_a: GO:0052034 ! effector-mediated suppression of host pattern-triggered immunity

[Term]
id: GO:0140425
name: galactose import across plasma membrane
namespace: biological_process
def: "The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:21621292, PMID:23254763]
is_a: GO:0015757 ! galactose transmembrane transport
is_a: GO:0140271 ! hexose import across plasma membrane

[Term]
id: GO:0140426
name: pathogen-associated molecular pattern receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [PMID:25744358]
synonym: "MAMP-triggered immunity signalling" EXACT []
synonym: "PAMP receptor signaling pathway" EXACT []
synonym: "PAMP-triggered immunity signalling pathway" EXACT []
synonym: "pathogen-associated molecular pattern signalling" EXACT []
synonym: "PTI signalling" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0140429
name: positive regulation of mitotic sister chromatid biorientation
namespace: biological_process
alt_id: GO:0098783
alt_id: GO:1990598
def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536, PMID:20739936, PMID:21306900]
synonym: "correction of merotelic kinetochore attachment, mitotic" NARROW []
synonym: "correction of mono-orientation defects" NARROW []
synonym: "correction of syntelic kinetochore attachment, mitotic" NARROW [GOC:vw]
synonym: "repair of mitotic merotelic kinetochore attachment defect" NARROW []
synonym: "repair of mitotic merotelic kinetochore attachment defects" NARROW []
synonym: "repair of mitotic mono-orientation defect" NARROW []
synonym: "repair of mitotic mono-orientation defects" NARROW []
is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling
is_a: GO:0140273 ! repair of mitotic kinetochore microtubule attachment defect
is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore
relationship: positively_regulates GO:1990758 ! mitotic sister chromatid biorientation

[Term]
id: GO:0140430
name: positive regulation of chromosome passenger complex localization to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore." [PMID:20739936]
is_a: GO:1905342 ! positive regulation of protein localization to kinetochore
relationship: positively_regulates GO:0072356 ! chromosome passenger complex localization to kinetochore

[Term]
id: GO:0140431
name: DNA-(abasic site) binding
namespace: molecular_function
def: "Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base." [PMID:23245849]
synonym: "DNA AP site binding" EXACT []
synonym: "DNA-(apurinic site) binding" NARROW []
synonym: "DNA-(apurinic site/apyrimidinic site) binding" EXACT []
synonym: "DNA-(apyrimidinic site) binding" NARROW []
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:0140432
name: 5'-hydroxyl dinucleotide hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA." [PMID:31777937]
is_a: GO:0004540 ! RNA nuclease activity

[Term]
id: GO:0140433
name: regulation of protein localization to meiotic spindle pole body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body." [PMID:22438582]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:1902363 ! regulation of protein localization to spindle pole body
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:1902441 ! protein localization to meiotic spindle pole body

[Term]
id: GO:0140434
name: positive regulation of protein localization to meiotic spindle pole body
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body." [PMID:22438582]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0140433 ! regulation of protein localization to meiotic spindle pole body
is_a: GO:1902365 ! positive regulation of protein localization to spindle pole body
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:1902441 ! protein localization to meiotic spindle pole body

[Term]
id: GO:0140435
name: negative regulation of protein localization to meiotic spindle pole body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a meiotic spindle pole body." [PMID:22438582]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0140433 ! regulation of protein localization to meiotic spindle pole body
is_a: GO:1902364 ! negative regulation of protein localization to spindle pole body
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:1902441 ! protein localization to meiotic spindle pole body

[Term]
id: GO:0140438
name: protein stearoylation
namespace: biological_process
def: "The covalent attachment of a stearoyl group to an amino acid in a protein." [PMID:26214738]
subset: gocheck_obsoletion_candidate
is_a: GO:0006497 ! protein lipidation

[Term]
id: GO:0140439
name: protein-cysteine S-stearoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]." [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59740]
xref: RHEA:59740
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0140440
name: protein-cysteine S-oleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]." [PMID:22247542, RHEA:59744]
xref: RHEA:59744
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0140441
name: protein-cysteine S-arachidonoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]." [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59748]
xref: RHEA:59748
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0140442
name: peroxide sensor activity
namespace: molecular_function
def: "Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:20919928]
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0140443
name: mitochondrion-plasma membrane adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:31582398]
synonym: "mitochondrion plasma membrane adaptor activity" EXACT []
synonym: "mitochondrion plasma membrane tether activity" EXACT []
synonym: "plasma membrane-mitochondrion adaptor activity" EXACT []
synonym: "plasma membrane-mitochondrion tether activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0140444
name: cytoskeleton-nuclear membrane anchor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane." [PMID:16237665]
synonym: "cytoskeletal protein-nuclear membrane adaptor activity" EXACT []
synonym: "cytoskeletal protein-nuclear membrane anchor activity" EXACT []
synonym: "cytoskeleton nuclear membrane anchor activity" EXACT []
synonym: "nuclear membrane-cytoskeleton anchor activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0140445
name: chromosome, telomeric repeat region
namespace: cellular_component
def: "A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop." [PMID:11352055, PMID:30208292]
is_a: GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0140446
name: fumigermin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus." [PMID:32083553]
synonym: "fumigermin anabolism" EXACT []
synonym: "fumigermin biosynthesis" EXACT []
synonym: "fumigermin formation" EXACT []
synonym: "fumigermin synthesis" EXACT []
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0140447
name: cytokine precursor processing
namespace: biological_process
def: "The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine." [PMID:29247995]
synonym: "interleukin maturation" NARROW []
synonym: "interleukin processing" NARROW []
is_a: GO:0140448 ! signaling receptor ligand precursor processing
relationship: part_of GO:0001816 ! cytokine production

[Term]
id: GO:0140448
name: signaling receptor ligand precursor processing
namespace: biological_process
alt_id: GO:0035638
def: "The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand." [PMID:29247995]
synonym: "ligand maturation" NARROW [GOC:bf]
synonym: "signal maturation" RELATED []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0140449
name: centromere-nuclear envelope anchor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location." [PMID:31635174]
synonym: "centromere nuclear envelope anchor activity" EXACT []
synonym: "centromere nuclear envelope tether activity" EXACT []
synonym: "centromere-inner nuclear envelope anchor activity" EXACT []
synonym: "centromere-inner nuclear envelope tether activity" EXACT []
synonym: "chromosome, centromeric region-nuclear envelope anchor activity" EXACT []
synonym: "nuclear envelope-centromere anchor activity" EXACT []
synonym: "nuclear envelope-centromere tether activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0140450
name: protein targeting to Golgi apparatus
namespace: biological_process
def: "The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation)." [PMID:18817523]
is_a: GO:0006605 ! protein targeting
is_a: GO:0034067 ! protein localization to Golgi apparatus
is_a: GO:0072594 ! establishment of protein localization to organelle

[Term]
id: GO:0140451
name: counting factor complex
namespace: cellular_component
def: "A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum." [PMID:10444594, PMID:12117815, PMID:12912898, PMID:16963635, PMID:18426773]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0140453
name: protein aggregate center
namespace: cellular_component
def: "Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773]
synonym: "PAC" BROAD []
synonym: "protein aggregate centre" EXACT []
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0140454
name: protein aggregate center assembly
namespace: biological_process
def: "The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773]
synonym: "PAC assembly" BROAD []
synonym: "protein aggregate center formation" EXACT []
synonym: "protein aggregate centre assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0140455
name: cytoplasm protein quality control
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773]
is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins

[Term]
id: GO:0140456
name: initial meiotic spindle pole body separation
namespace: biological_process
def: "The release of duplicated meiotic spindle pole bodies (SPBs)." [PMID:31532702]
synonym: "initial spindle pole body separation involved in meiosis I" EXACT []
synonym: "meiotic spindle pole body duplication" EXACT []
is_a: GO:0110100 ! spindle pole body separation
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:0140457
name: protein demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a protein." [PMID:24498420, PMID:28360925]
is_a: GO:0032451 ! demethylase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140459
name: response to Gram-positive bacterium
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium." [PMID:23664307]
is_a: GO:0009617 ! response to bacterium

[Term]
id: GO:0140460
name: response to Gram-negative bacterium
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium." [PMID:23664307]
is_a: GO:0009617 ! response to bacterium

[Term]
id: GO:0140461
name: obsolete subtelomeric heterochromatin organization
namespace: biological_process
def: "OBSOLETE. The organization of chromatin into heterochromatin at the subtelomeric region of a chromosome." [PMID:26744419]
comment: This term has been obsoleted because it represents a different process, GO:0097240 attachment of telomeric heterochromatin to nuclear envelope.
is_obsolete: true

[Term]
id: GO:0140462
name: pericentric heterochromatin organization
namespace: biological_process
def: "The organization of chromatin into heterochromatin at the pericentric region of a chromosome." [PMID:26744419]
is_a: GO:0031507 ! heterochromatin formation

[Term]
id: GO:0140463
name: chromatin-protein adaptor activity
namespace: molecular_function
def: "An adaptor activity that brings together a protein and a region of the chromatin, such as a nucleosome, to establish or maintain the chromatin localization of the protein, or the complex to which it belongs." [PMID:32277274]
synonym: "chromatin adaptor" EXACT []
synonym: "chromatin adaptor activity" EXACT []
synonym: "chromatin receptor" EXACT []
synonym: "chromatin recruitment" RELATED []
synonym: "chromatin-protein adaptor" EXACT []
synonym: "protein-chromatin adaptor activity" EXACT []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0140464
name: subnuclear spatial organization of silent mating-type cassette heterochromatin
namespace: biological_process
def: "The localization of silent mating-type cassette heterochromatin at a specific location in the nucleus." [PMID:26744419]
synonym: "silent mating-type cassette heterochromatin organization" RELATED []
synonym: "silent mating-type cassette heterochromatin spatial organization in the nucleus" EXACT []
is_a: GO:0097240 ! chromosome attachment to the nuclear envelope

[Term]
id: GO:0140466
name: iron-sulfur cluster export from the mitochondrion
namespace: biological_process
def: "The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane." [PMID:31040179]
is_a: GO:1902497 ! iron-sulfur cluster transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0140467
name: integrated stress response signaling
namespace: biological_process
def: "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041]
synonym: "ISR" RELATED []
xref: Wikipedia:Integrated_stress_response
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0140468
name: HRI-mediated signaling
namespace: biological_process
def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock." [PMID:27629041]
synonym: "EIF2AK1-mediated signaling" EXACT []
is_a: GO:0140467 ! integrated stress response signaling

[Term]
id: GO:0140469
name: GCN2-mediated signaling
namespace: biological_process
alt_id: GO:0060733
def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation." [PMID:27629041]
synonym: "EIF2AK4-mediated signaling" EXACT []
synonym: "regulation of eIF2 alpha phosphorylation by amino acid starvation" NARROW []
is_a: GO:0140467 ! integrated stress response signaling

[Term]
id: GO:0140471
name: positive regulation of transepithelial migration of symbiont in host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host." [PMID:29113016]
synonym: "positive regulation of symbiont-mediated migration across host transepithelium" EXACT []
synonym: "positive regulation of symbiont-mediated migration through host transepithelium" EXACT []
synonym: "positive regulation of transmigration of symbiont in host" RELATED []
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0035756 ! symbiont-mediated migration across host transepithelium

[Term]
id: GO:0140472
name: cell cortex of non-growing cell tip
namespace: cellular_component
def: "The region directly beneath the plasma membrane at the cell tip at which no growth takes place." [PMID:17895368]
is_a: GO:0051285 ! cell cortex of cell tip
relationship: part_of GO:0035839 ! non-growing cell tip

[Term]
id: GO:0140473
name: telomere-nuclear envelope anchor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location." [PMID:31635174]
synonym: "nuclear envelope-telomere anchor activity" EXACT []
synonym: "telomere-nuclear envelope anchoring activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0140474
name: mitochondrion-endoplasmic reticulum membrane tether activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:19556461, PMID:27875684]
synonym: "endoplasmic reticulum-mitochondrion membrane adaptor activity" EXACT []
synonym: "endoplasmic reticulum-mitochondrion membrane tether activity" EXACT []
synonym: "ER-mitochondrion membrane adaptor activity" EXACT []
synonym: "ER-mitochondrion membrane tether activity" EXACT []
synonym: "mitochondrion-endoplasmic reticulum membrane adaptor activity" EXACT []
synonym: "mitochondrion-ER membrane adaptor activity" EXACT []
synonym: "mitochondrion-ER membrane tether activity" EXACT []
is_a: GO:0170009 ! endoplasmic reticulum-organelle membrane tether activity

[Term]
id: GO:0140475
name: spindle pole body anchor activity
namespace: molecular_function
def: "The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way." [PMID:19942852]
is_a: GO:0008093 ! cytoskeletal anchor activity

[Term]
id: GO:0140479
name: ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase
namespace: biological_process
def: "A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide." [PMID:22209968, PMID:24828577]
is_a: GO:0052699 ! ergothioneine biosynthetic process

[Term]
id: GO:0140480
name: mitotic spindle pole body insertion into the nuclear envelope
namespace: biological_process
def: "A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane." [PMID:19487457, PMID:24529240]
synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT []
synonym: "establishment of spindle pole body localization in nuclear envelope" EXACT []
synonym: "establishment of spindle pole body localization to nuclear envelope" EXACT []
is_a: GO:1990608 ! mitotic spindle pole body localization

[Term]
id: GO:0140481
name: ABC-type iron-sulfur cluster transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)." [PMID:31040179]
synonym: "ATPase-coupled Fe-S cluster transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled iron-sulfur cluster transmembrane transporter activity" RELATED []
xref: TC:3.A.1.210.1
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0140482
name: iron sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron." [PMID:11956219, PMID:25806539]
is_a: GO:0140784 ! metal ion sensor activity

[Term]
id: GO:0140483
name: kinetochore adaptor activity
namespace: molecular_function
def: "The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way." [PMID:22521786]
synonym: "inner kinetochore adaptor activity" NARROW []
synonym: "outer kinetochore adaptor activity" NARROW []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0140484
name: 5-aminolevulinic acid import across plasma membrane
namespace: biological_process
def: "The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol." [PMID:31989647]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0140485
name: 5-aminolevulinic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other." [PMID:31989647]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0140486
name: zinc ion sequestering activity
namespace: molecular_function
def: "Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:12050156]
is_a: GO:0140487 ! metal ion sequestering activity

[Term]
id: GO:0140487
name: metal ion sequestering activity
namespace: molecular_function
def: "Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:12050156]
is_a: GO:0140313 ! molecular sequestering activity

[Term]
id: GO:0140488
name: heme receptor activity
namespace: molecular_function
def: "Binding specifically to heme to deliver it to a transport vesicle." [PMID:28193844, PMID:32185489]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0140489
name: molecular template activity
namespace: molecular_function
def: "The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence." [GOC:pg]
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140490
name: microtubule nucleator activity
namespace: molecular_function
def: "The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly." [PMID:20631709, PMID:21993292]
synonym: "microtubule nucleation template activity" EXACT []
is_a: GO:0140489 ! molecular template activity

[Term]
id: GO:0140492
name: metal-dependent deubiquitinase activity
namespace: molecular_function
def: "An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [PMID:19489724]
synonym: "metal-dependent ubiquitin-like hydrolase activity" EXACT []
synonym: "metal-dependent ubiquitinyl-like hydrolase activity" EXACT []
is_a: GO:0008237 ! metallopeptidase activity
is_a: GO:0101005 ! deubiquitinase activity

[Term]
id: GO:0140493
name: very long-chain fatty acid beta-oxidation
namespace: biological_process
def: "A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:ha, PMID:17028011, PMID:32169171]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
is_a: GO:0033540 ! fatty acid beta-oxidation using acyl-CoA oxidase
is_a: GO:0042760 ! very long-chain fatty acid catabolic process

[Term]
id: GO:0140494
name: migrasome
namespace: cellular_component
def: "A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration." [PMID:25342562, PMID:31371827]
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0140495
name: migracytosis
namespace: biological_process
def: "A cell migration-dependent mechanism for releasing cellular contents." [PMID:25342562]
is_a: GO:0140352 ! export from cell

[Term]
id: GO:0140496
name: gamma-tubulin complex binding
namespace: molecular_function
def: "Binding to a gamma-tubulin complex." [PMID:30174135]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:0140497
name: mannan polymerase II complex
namespace: cellular_component
def: "A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p." [PMID:9430634]
is_a: GO:0000136 ! mannan polymerase complex

[Term]
id: GO:0140498
name: mannan polymerase I complex
namespace: cellular_component
def: "A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p." [PMID:9430634]
is_a: GO:0000136 ! mannan polymerase complex

[Term]
id: GO:0140499
name: negative regulation of mitotic spindle assembly checkpoint signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling." [PMID:28017606]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition
is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation
is_a: GO:0090233 ! negative regulation of spindle checkpoint
is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint
relationship: negatively_regulates GO:0007094 ! mitotic spindle assembly checkpoint signaling

[Term]
id: GO:0140500
name: regulation of reticulophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reticulophagy." [PMID:32735772]
synonym: "regulation of autophagy of the endoplasmic reticulum" EXACT []
synonym: "regulation of autophagy of the ER" EXACT []
synonym: "regulation of endoplasmic reticulum autophagy" EXACT []
synonym: "regulation of endoplasmic reticulum degradation" RELATED []
synonym: "regulation of ER autophagy" EXACT []
synonym: "regulation of ER degradation" RELATED []
synonym: "regulation of ER-phagy" EXACT []
is_a: GO:0016241 ! regulation of macroautophagy
relationship: regulates GO:0061709 ! reticulophagy

[Term]
id: GO:0140501
name: positive regulation of reticulophagy
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of reticulophagy." [PMID:32735772]
synonym: "positive regulation of autophagy of the endoplasmic reticulum" EXACT []
synonym: "positive regulation of autophagy of the ER" EXACT []
synonym: "positive regulation of endoplasmic reticulum autophagy" EXACT []
synonym: "positive regulation of endoplasmic reticulum degradation" RELATED []
synonym: "positive regulation of ER autophagy" EXACT []
synonym: "positive regulation of ER degradation" RELATED []
synonym: "positive regulation of ER-phagy" EXACT []
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0140500 ! regulation of reticulophagy
relationship: positively_regulates GO:0061709 ! reticulophagy

[Term]
id: GO:0140502
name: effector-mediated suppression of host salicylic acid-mediated innate immune signaling
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signaling." [PMID:25438793, PMID:30651637]
synonym: "effector-mediated disruption of host salicylic acid-mediated innate immune signalling" EXACT []
synonym: "effector-mediated suppression of host salicylic acid-mediated innate immune signalling" EXACT []
is_a: GO:0052003 ! symbiont-mediated suppression of defense-related host salicylic acid-mediated signal transduction pathway
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway
is_a: GO:0140404 ! effector-mediated perturbation of host innate immune response by symbiont

[Term]
id: GO:0140504
name: microlipophagy
namespace: biological_process
def: "Degradation of a lipid droplet by microautophagy." [PMID:25070953, PMID:28394250, PMID:28838958, PMID:29293450, PMID:29601311]
synonym: "lipid droplet autophagy" EXACT [PMID:29293450]
is_a: GO:0016237 ! microautophagy

[Term]
id: GO:0140505
name: regulation of microlipophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion." [PMID:28394250, PMID:29601311]
is_a: GO:0010506 ! regulation of autophagy
relationship: regulates GO:0140504 ! microlipophagy

[Term]
id: GO:0140506
name: endoplasmic reticulum-autophagosome adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy." [PMID:32735772]
synonym: "autophagosome-endoplasmic reticulum anchor" EXACT []
synonym: "autophagosome-ER anchor" EXACT []
synonym: "ER- autophagosome anchor" EXACT []
is_a: GO:0160183 ! autophagosome-membrane adaptor activity
is_a: GO:0170009 ! endoplasmic reticulum-organelle membrane tether activity

[Term]
id: GO:0140507
name: granzyme-mediated programmed cell death signaling pathway
namespace: biological_process
def: "The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells." [PMID:32299851]
synonym: "granzyme-mediated cell death signaling pathway" BROAD []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0012501 ! programmed cell death

[Term]
id: GO:0140509
name: epithelium-like organization
namespace: biological_process
def: "The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins." [PMID:21393547, PMID:22902739]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0140510
name: mitotic nuclear bridge
namespace: cellular_component
def: "A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei." [PMID:32848252]
synonym: "nuclear bridge" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0140511
name: mitotic nuclear bridge stalk
namespace: cellular_component
def: "Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes." [PMID:32848252]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0140510 ! mitotic nuclear bridge

[Term]
id: GO:0140512
name: mitotic nuclear bridge midzone
namespace: cellular_component
def: "The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei." [PMID:32848252]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0140510 ! mitotic nuclear bridge

[Term]
id: GO:0140513
name: nuclear protein-containing complex
namespace: cellular_component
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]
subset: gocheck_do_not_annotate
synonym: "nuclear complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0140515
name: mitotic nuclear bridge organization
namespace: biological_process
def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis." [PMID:32848252]
is_a: GO:0101024 ! mitotic nuclear membrane organization

[Term]
id: GO:0140516
name: mitotic nuclear pore complex disassembly
namespace: biological_process
def: "The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis." [PMID:32848252]
synonym: "nuclear pore complex disassembly during mitosis" EXACT []
is_a: GO:0006999 ! nuclear pore organization
is_a: GO:0007077 ! mitotic nuclear membrane disassembly
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0140517
name: protein-RNA adaptor activity
namespace: molecular_function
def: "The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way." [PMID:24470144]
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0140522
name: fusogenic activity
namespace: molecular_function
def: "The activity of joining two lipid bilayers to form a single membrane." [PMID:10332732, PMID:11493675, PMID:12600315, PMID:32100701, PMID:32641474]
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140523
name: GTPase-dependent fusogenic activity
namespace: molecular_function
def: "A GTPase activity that mediates the joining two lipid bilayers to form a single membrane." [PMID:29663589]
synonym: "membrane fusion GTPase activity" EXACT []
is_a: GO:0140522 ! fusogenic activity

[Term]
id: GO:0140525
name: antipodal site
namespace: cellular_component
def: "The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication." [PMID:12455998, PMID:17462016, PMID:8045928]
synonym: "antipodal zone" EXACT []
is_a: GO:0020023 ! kinetoplast

[Term]
id: GO:0140526
name: double membrane vesicle viral factory assembly
namespace: biological_process
def: "A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle." [PMID:32555292]
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0140527
name: reciprocal homologous recombination
namespace: biological_process
def: "A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules." [PMID:17846636]
is_a: GO:0035825 ! homologous recombination

[Term]
id: GO:0140528
name: bilobe structure assembly
namespace: biological_process
def: "The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone)." [PMID:18443217, PMID:32675283]
synonym: "bilobe structure biogenesis" EXACT []
synonym: "bilobe structure formation" EXACT []
synonym: "kinetoplastid flagellar hook complex assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0140529
name: CMG complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes." [PMID:22718908, PMID:28501329]
is_a: GO:0071163 ! DNA replication preinitiation complex assembly
relationship: part_of GO:1902315 ! nuclear cell cycle DNA replication initiation

[Term]
id: GO:0140530
name: MCM complex loading
namespace: biological_process
def: "The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly." [PMID:23603117, PMID:28191893, PMID:28191894, PMID:28501329]
synonym: "MCM complex loading at replication origin" EXACT []
synonym: "MCM double hexamer formation at replication origin" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:1902315 ! nuclear cell cycle DNA replication initiation

[Term]
id: GO:0140531
name: obsolete regulation of osmosensory signaling MAPK cascade
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of osmosensory signaling MAPK cascade." [PMID:31911490]
comment: This term was obsoleted because it represents the same process as regulation of p38MAPK cascade ; GO:1900744.
is_obsolete: true
replaced_by: GO:1900744

[Term]
id: GO:0140532
name: obsolete negative regulation of osmosensory signaling MAPK cascade
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling MAPK cascade." [PMID:31911490]
comment: This term was obsoleted because it represents the same process as negative regulation of p38MAPK cascade ; GO:1903753.
is_obsolete: true
replaced_by: GO:1903753

[Term]
id: GO:0140533
name: symbiont-mediated suppression of host RNAi-mediated antiviral immune response
namespace: biological_process
def: "A process by which a symbiont inhibits or disrupts the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17693253]
synonym: "suppression of host RNAi-mediated antiviral immune response" EXACT []
synonym: "suppression of host RNAi-mediated antiviral immunity" EXACT []
synonym: "suppression of host RNAi-mediated gene silencing" EXACT []
is_a: GO:0052170 ! symbiont-mediated suppression of host innate immune response

[Term]
id: GO:0140534
name: endoplasmic reticulum protein-containing complex
namespace: cellular_component
def: "A protein complex that is part of an endoplasmic reticulum." [GOC:pg]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0140535
name: intracellular protein-containing complex
namespace: cellular_component
def: "A protein-containing complex located intracellularly." [GOC:pg]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0140536
name: obsolete nuclear receptor corepressor activity
namespace: molecular_function
def: "OBSOLETE. A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [PMID:7566114, PMID:7566126, PMID:9238851]
comment: The reason for obsoletion is that these activities are not necessarily specific for nuclear receptors subclass of dbTFs, so that distinction leads to misannotations.
synonym: "nuclear corepressor activity" BROAD []
is_obsolete: true
replaced_by: GO:0003714

[Term]
id: GO:0140537
name: transcription regulator activator activity
namespace: molecular_function
def: "A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification." [PMID:9597751]
comment: Usage guidance: transcription regulator activators bind to a transcription regulator to allow it to reach the chromatin or to contact other transcriptional regulators. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001216 ; DNA-binding transcription activator activity or GO:0003713; transcription coactivator activity; those activities respectively bind DNA themselves or positively regulate a transcription regulator when it is located at the chromatin.
is_a: GO:0140677 ! molecular function activator activity

[Term]
id: GO:0140538
name: negative regulation of conjugation with zygote
namespace: biological_process
def: "A process that prevents a zygote from fusing an additional cell." [PMID:30089908]
is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion

[Term]
id: GO:0140539
name: regulation of melanotic encapsulation of foreign target
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanotic encapsulation of foreign target." [PMID:15749104, PMID:18457993]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0035007 ! regulation of melanization defense response
relationship: regulates GO:0035011 ! melanotic encapsulation of foreign target

[Term]
id: GO:0140540
name: negative regulation melanotic encapsulation of foreign target
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanotic encapsulation of foreign target." [PMID:15749104, PMID:18457993]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0035009 ! negative regulation of melanization defense response
is_a: GO:0140539 ! regulation of melanotic encapsulation of foreign target
relationship: negatively_regulates GO:0035011 ! melanotic encapsulation of foreign target

[Term]
id: GO:0140541
name: piRNA transcription
namespace: biological_process
def: "The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [PMID:28847004]
synonym: "Piwi-associated RNA transcription" EXACT []
synonym: "PIWI-interacting RNA transcription" EXACT []
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0140542
name: regulation of piRNA transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of a piRNA." [PMID:28847004]
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0140541 ! piRNA transcription

[Term]
id: GO:0140543
name: positive regulation of piRNA transcription
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the synthesis of piRNA." [PMID:28847004]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:0140542 ! regulation of piRNA transcription
relationship: positively_regulates GO:0140541 ! piRNA transcription

[Term]
id: GO:0140544
name: septin collar organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar." [PMID:21736496, PMID:32386534]
synonym: "cellular bud neck septin hourglass organization" EXACT []
is_a: GO:0032185 ! septin cytoskeleton organization

[Term]
id: GO:0140545
name: ATP-dependent protein disaggregase activity
namespace: molecular_function
def: "An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates." [PMID:26312418]
synonym: "protein disaggregase activity" BROAD []
synonym: "protein unfoldase activity" BROAD []
is_a: GO:0140657 ! ATP-dependent activity
is_a: GO:0140776 ! protein-containing complex destabilizing activity

[Term]
id: GO:0140546
name: defense response to symbiont
namespace: biological_process
def: "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg]
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0140547
name: acquisition of seed longevity
namespace: biological_process
def: "The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes." [PMID:26637538]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0140548
name: envenomation resulting in blood agglutination in another organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with specific proteins binding to cell-surface carbohydrates and causing calcium-dependent agglutination of blood cells in the bitten organism." [PMID:10484740]
synonym: "envenomation resulting in blood agglutination in other organism" EXACT []
synonym: "envenomation resulting in erythrocytes agglutination in other organism" EXACT []
synonym: "envenomation resulting in red blood cells agglutination in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism

[Term]
id: GO:0140549
name: spore inner membrane
namespace: cellular_component
def: "The membrane surrounding the spore core (endospore core) that separates it from its external environment." [PMID:23202530]
synonym: "spore membrane" BROAD []
is_a: GO:0016020 ! membrane

[Term]
id: GO:0140550
name: phosphatidylinositol-4,5-bisphosphate sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate." [PMID:33172987]
synonym: "phosphatidylinositol-4,5-bisphosphate sensing activity" EXACT []
is_a: GO:0106254 ! lipid sensor activity

[Term]
id: GO:0140552
name: TEAD-YAP complex
namespace: cellular_component
alt_id: GO:0071147
alt_id: GO:0071148
alt_id: GO:0071149
alt_id: GO:0071150
alt_id: GO:0071151
def: "A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
synonym: "TEAD-1-YAP complex" NARROW []
synonym: "TEAD-2 multiprotein complex" NARROW []
synonym: "TEAD-2-YAP complex" NARROW []
synonym: "TEAD-3-YAP complex" NARROW []
synonym: "TEAD-4-YAP complex" NARROW []
xref: CORUM:2870
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:0140560
name: xylosyl alpha-1,3-xylosyltransferase activity
namespace: molecular_function
def: "Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains." [PMID:22117070, PMID:8982869, RHEA:22820]
xref: EC:2.4.2.62
xref: RHEA:22820
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0140561
name: EGF-domain serine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine." [RHEA:58116]
xref: EC:2.4.1.376
xref: RHEA:58116
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0140562
name: EGF-domain serine xylosyltransferase activity
namespace: molecular_function
def: "Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine." [RHEA:62016]
xref: EC:2.4.2.63
xref: RHEA:62016
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0140563
name: UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity
namespace: molecular_function
def: "Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine." [EC:2.4.2.42, PMID:30127001, RHEA:56064]
xref: EC:2.4.2.42
xref: RHEA:56064
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0140566
name: histone reader activity
namespace: molecular_function
def: "A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery." [PMID:11498575, PMID:25688442, PMID:31082667, PMID:32260176, PMID:34726351]
synonym: "epigenetic reader" BROAD []
synonym: "histone reader" EXACT []
is_a: GO:0140463 ! chromatin-protein adaptor activity

[Term]
id: GO:0140567
name: membrane protein dislocase activity
namespace: molecular_function
def: "The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis." [PMID:24821790, PMID:28712723, PMID:32973005]
synonym: "transmembrane helix dislocase\ntransmembrane protein dislocase activity" RELATED []
is_a: GO:0140318 ! protein transporter activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0140568
name: extraction of mislocalized protein from membrane
namespace: biological_process
def: "The removal of a mislocalized protein from a cellular membrane." [PMID:24821790, PMID:28712723, PMID:32973005]
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0140569
name: extraction of mislocalized protein from ER membrane
namespace: biological_process
def: "The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane." [PMID:32973005]
is_a: GO:0140568 ! extraction of mislocalized protein from membrane

[Term]
id: GO:0140570
name: extraction of mislocalized protein from mitochondrial outer membrane
namespace: biological_process
def: "The removal of a mislocalized protein from the mitochondrial outer membrane." [PMID:32973005]
synonym: "extraction of mislocalized protein from outer mitochondrion membrane" EXACT []
is_a: GO:0140568 ! extraction of mislocalized protein from membrane

[Term]
id: GO:0140571
name: transmembrane ascorbate ferrireductase activity
namespace: molecular_function
def: "Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction." [PMID:16911521, PMID:24449903, RHEA:30403]
synonym: "ascorbate-cytochrome b5 reductase activity" EXACT []
synonym: "L-ascorbate-cytochrome-b5 reductase activity" EXACT []
synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT []
xref: EC:7.2.1.3
xref: MetaCyc:RXN-15598
xref: RHEA:30403
is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity
is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions

[Term]
id: GO:0140572
name: vacuole fission
namespace: biological_process
def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199]
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0140573
name: histone H3-containing nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures." [PMID:33155135]
synonym: "histone H3 containing nucleosome" EXACT []
is_a: GO:0000786 ! nucleosome

[Term]
id: GO:0140575
name: transmembrane monodehydroascorbate reductase activity
namespace: molecular_function
def: "Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction." [PMID:1623014, RHEA:66524]
xref: RHEA:66524
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0140576
name: ascorbate homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of ascorbate at the level of a cell." [PMID:1623014, PMID:17068337, PMID:32547589]
synonym: "cellular ascorbate homeostasis" NARROW []
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0140579
name: obsolete oxidoreductase activity, reducing metal ions
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction in which the metal ion is reduced." [PMID:14499595]
comment: This term was obsoleted because it is an unnecessary grouping class.
is_obsolete: true
consider: GO:0016722

[Term]
id: GO:0140580
name: mitochondrion autophagosome adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy." [PMID:33138913]
synonym: "mitophagy receptor" EXACT []
is_a: GO:0160183 ! autophagosome-membrane adaptor activity

[Term]
id: GO:0140581
name: P-type monovalent copper transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out)." [RHEA:25792]
comment: Note that this enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC:7.2.2.9, which mainly transports the divalent copper ion (source: EC:7.2.2.8).
xref: EC:7.2.2.8
xref: MetaCyc:RXN-14455
xref: RHEA:25792
is_a: GO:0005375 ! copper ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0140582
name: adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
namespace: biological_process
def: "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by extracellular cAMP binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [PMID:9578623]
synonym: "extracellular cAMP signaling pathway" EXACT []
is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway

[Term]
id: GO:0140584
name: chromatin extrusion motor activity
namespace: molecular_function
def: "A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis." [PMID:23074191, PMID:26499245, PMID:27210764]
synonym: "chromatin extrusion activity" EXACT []
is_a: GO:0015616 ! DNA translocase activity

[Term]
id: GO:0140585
name: promoter-enhancer loop anchoring activity
namespace: molecular_function
def: "Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop." [PMID:32213323]
comment: Note that GO does not separately defines enhancers, since this concept is very close to that of cis-regulatory elements. However the literature refers to 'promoter-enhancer loops' to describe loops that bring together cis-regulatory elements. Note also that while SO defines 'promoter' as the core promoter, here it is used to mean a cis-regulatory element.
synonym: "enhancer-promoter loop anchoring activity" EXACT []
is_a: GO:0140587 ! chromatin loop anchoring activity

[Term]
id: GO:0140586
name: promoter-terminator loop anchoring activity
namespace: molecular_function
def: "Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop." [PMID:19933151]
comment: Note that GO does not separately defines enhancers, since this concept is very close to that of cis-regulatory elements. However the literature refers to 'promoter-enhancer loops' to describe loops that bring together cis-regulatory elements. Note also that while SO defines 'promoter' as the core promoter, here it is used to mean a cis-regulatory element.
synonym: "terminator-promoter loop anchoring activity" EXACT []
is_a: GO:0140587 ! chromatin loop anchoring activity

[Term]
id: GO:0140587
name: chromatin loop anchoring activity
namespace: molecular_function
def: "Bridging together two DNA loop anchors together, maintaining a chromatin loop." [PMID:32213323]
synonym: "chromosomal loop binding" EXACT []
synonym: "DNA loop binding" EXACT []
is_a: GO:0031490 ! chromatin DNA binding
is_a: GO:0106260 ! DNA-DNA tethering activity

[Term]
id: GO:0140588
name: chromatin looping
namespace: biological_process
def: "A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome." [PMID:32213323]
comment: To describe the molecular function associated with chromatin looping, consider 'chromatin extrusion motor activity'; GO:0140584.
synonym: "chromatin folding" RELATED []
synonym: "chromatin loop assembly" EXACT []
synonym: "DNA loop extrusion" EXACT []
synonym: "DNA looping" BROAD []
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0140590
name: effector-mediated suppression of host defense response
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:28082413]
synonym: "effector-mediated suppression of host defenses" RELATED []
synonym: "effector-mediated suppression of host defenses by symbiont" EXACT []
is_a: GO:0140415 ! effector-mediated perturbation of host defenses by symbiont

[Term]
id: GO:0140591
name: nuclear envelope budding
namespace: biological_process
def: "The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm." [PMID:27236823, PMID:32503943]
is_a: GO:0051168 ! nuclear export

[Term]
id: GO:0140592
name: histone H3R8 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3." [PMID:20708585, PMID:31533925]
synonym: "histone H3R8 arginine methylase activity" EXACT []
synonym: "histone H3R8 arginine methyltransferase activity" EXACT []
synonym: "histone methyltransferase activity (H3-R8 specific)" EXACT []
synonym: "histone-H3R8 methyltransferase activity" EXACT []
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0140593
name: host apoplast
namespace: cellular_component
def: "The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:28082413]
synonym: "host cell apoplast" EXACT []
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0140594
name: xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase." [PMID:28082413]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0140595
name: MIM complex
namespace: cellular_component
def: "A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2." [PMID:19944477, PMID:22467864, PMID:33035511]
synonym: "mitochondrial outer import machinery" EXACT []
is_a: GO:0005742 ! mitochondrial outer membrane translocase complex

[Term]
id: GO:0140596
name: TOM complex
namespace: cellular_component
def: "A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane." [PMID:33035511]
synonym: "translocase of the outer mitochondrial membrane" EXACT []
is_a: GO:0005742 ! mitochondrial outer membrane translocase complex

[Term]
id: GO:0140597
name: protein carrier chaperone
namespace: molecular_function
def: "Binding to and carrying a protein between two different cellular components by moving along with the target protein." [PMID:7628437]
synonym: "protein carrier activity" EXACT []
synonym: "protein chaperone" BROAD []
is_a: GO:0140104 ! molecular carrier activity

[Term]
id: GO:0140598
name: lipoprotein carrier activity
namespace: molecular_function
def: "Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein." [PMID:7628437]
is_a: GO:0140597 ! protein carrier chaperone

[Term]
id: GO:0140599
name: mitotic nuclear bridge midzone membrane domain
namespace: cellular_component
def: "A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets." [PMID:25963819, PMID:32502403]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0140512 ! mitotic nuclear bridge midzone

[Term]
id: GO:0140602
name: nucleolar peripheral inclusion body
namespace: cellular_component
def: "Inclusion bodies located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress or starvation." [PMID:33176152, PMID:37128864]
synonym: "nucleolar ring" NARROW []
synonym: "NuRs" RELATED []
is_a: GO:0042405 ! nuclear inclusion body

[Term]
id: GO:0140603
name: obsolete ATP hydrolysis activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators]
comment: This term was deprecated because it was created in the wrong branch on the ontology.
is_obsolete: true
replaced_by: GO:0016887

[Term]
id: GO:0140604
name: mycofactocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA." [PMID:21223593, PMID:27312813, PMID:30183269, PMID:30778644, PMID:31381312, PMID:33014324]
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0140605
name: proton motive force-driven motor activity
namespace: molecular_function
def: "A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella." [PMID:18216858]
is_a: GO:0003774 ! cytoskeletal motor activity

[Term]
id: GO:0140608
name: cysteine-type endopeptidase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a cysteine-type endopeptidase." [PMID:32558991]
synonym: "caspase activator activator activity" NARROW []
is_a: GO:0061133 ! endopeptidase activator activity

[Term]
id: GO:0140609
name: phycocyanobilin biosynthetic process
namespace: biological_process
def: "The chemical reactions or pathway resulting in the formation of phycocyanobilin, which involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IX alpha. Biliverdin IX alpha is subsequently converted to phycocyanobilin by a ferredoxin-dependent oxidoreductase (PCYA)." [PMID:23345435]
synonym: "phycocyanobilin biosynthesis" EXACT []
is_a: GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:0140610
name: RNA sequestering activity
namespace: molecular_function
def: "Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:29084823]
is_a: GO:0140313 ! molecular sequestering activity

[Term]
id: GO:0140612
name: DNA damage sensor activity
namespace: molecular_function
def: "A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response." [PMID:31995034]
synonym: "DNA damage sensing activity" EXACT []
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0140613
name: P-type manganese transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate." [PMID:11134055, PMID:15590060, PMID:15831496, PMID:21187401, RHEA:66820]
xref: MetaCyc:RXN-20940
xref: RHEA:66820
is_a: GO:0005384 ! manganese ion transmembrane transporter activity
is_a: GO:0015662 ! P-type ion transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity

[Term]
id: GO:0140614
name: 1,8-dihydroxynaphthalene-melanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin." [PMID:12788746, PMID:23998343]
synonym: "DHN-melanin biosynthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0140615
name: ATP-dependent citrate lyase complex
namespace: cellular_component
def: "A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA." [PMID:12376641]
synonym: "citrate lyase complex" BROAD []
synonym: "citrate synthase complex" BROAD []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0140616
name: iodotyrosine deiodinase activity
namespace: molecular_function
def: "Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates." [PMID:15289438, PMID:18434651, PMID:25395621, PMID:27643701, RHEA:32479]
synonym: "iodide peroxidase-tyrosine iodinase activity" RELATED []
synonym: "iodotyrosine deiodase activity" RELATED []
synonym: "monoiodotyrosine deiodinase activity" RELATED []
synonym: "tyrosine iodinase activity" RELATED []
xref: EC:1.21.1.1
xref: RHEA:32479
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0140617
name: obsolete transvection
namespace: biological_process
def: "OBSOLETE. An epigenetic regulation of transcription by physical interaction between a cis-acting element (enhancer, silencer) of one allele on one chromosome and the promoter of the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression." [PMID:24236213, PMID:33479152]
comment: This term was obsoleted because it represents an observation, not a GO process.
is_obsolete: true
consider: GO:0040029

[Term]
id: GO:0140618
name: ferric-chelate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH." [RHEA:15061]
synonym: "ferric chelate reductase activity" BROAD []
synonym: "iron chelate reductase activity" BROAD []
synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7]
xref: EC:1.16.1.7
xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN
xref: RHEA:15061
is_a: GO:0000293 ! ferric-chelate reductase activity
is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[Term]
id: GO:0140619
name: DNA strand exchange activator activity
namespace: molecular_function
def: "Binds to and increases a DNA strand exchange activity." [PMID:33493431]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0140620
name: DNA strand exchange inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces a DNA strand exchange activity." [PMID:33493431]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0140621
name: type I pilus
namespace: cellular_component
def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus rod, a homopolymer of ~1000 FimA subunits." [PMID:28496159, PMID:29345620]
synonym: "type 1 pilus" EXACT []
synonym: "type I fimbriae" EXACT []
synonym: "type I pili" EXACT []
is_a: GO:0009289 ! pilus

[Term]
id: GO:0140622
name: ER-to-endosome phospholipid transfer complex
namespace: cellular_component
def: "Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site." [GOC:lnp, PMID:20016005, PMID:24366873]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0140623
name: type I pilus assembly
namespace: biological_process
def: "The assembly from its constituent parts of a type I pilus." [PMID:1679330]
synonym: "T1P assembly" BROAD []
synonym: "type 1 pilus biogenesis" EXACT []
synonym: "type I fimbria assembly" EXACT []
synonym: "type I fimbria biogenesis" EXACT []
synonym: "type I fimbriae assembly" EXACT []
synonym: "type I fimbriae biogenesis" EXACT []
synonym: "type I fimbrial assembly" EXACT []
synonym: "type I fimbrial biogenesis" EXACT []
synonym: "type I fimbrium assembly" EXACT []
synonym: "type I fimbrium biogenesis" EXACT []
is_a: GO:0009297 ! pilus assembly

[Term]
id: GO:0140624
name: EGAD pathway
namespace: biological_process
def: "The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation." [PMID:31368600]
is_a: GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0140625
name: opioid growth factor receptor activity
namespace: molecular_function
def: "Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes." [PMID:11890982]
synonym: "met-enkephalin receptor activity" RELATED []
synonym: "metenkefalin receptor activity" RELATED []
synonym: "methionine enkephalin receptor activity" EXACT []
is_a: GO:0001653 ! peptide receptor activity

[Term]
id: GO:0140626
name: opioid growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an opioid growth factor receptor binding to its physiological ligand, opioid growth factor (OGF, met-enkephalin). The OGF-OGFr complex leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 (POLD4) and p16 (CDKN2A)." [PMID:19675283, PMID:19923357]
comment: Note that this term represents the activation of the zeta-opioid receptor. Do not confuse with GO:0038003 ; G protein-coupled opioid receptor signaling pathway, activated by the delta, kappa, mu, and nociceptin opioid receptors.
xref: Wikipedia:OGFr
xref: Wikipedia:Opioid_receptor
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0140627
name: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms." [PMID:29775578, PMID:29779948]
synonym: "DesCEND" EXACT []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0140628
name: outward rectifier potassium channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel." [PMID:28108814]
is_a: GO:0019870 ! potassium channel inhibitor activity

[Term]
id: GO:0140629
name: small conductance calcium-activated potassium channel inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel." [PMID:20562108]
is_a: GO:0019870 ! potassium channel inhibitor activity

[Term]
id: GO:0140630
name: all-trans-phytoene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate." [PMID:12641468, PMID:7896759]
synonym: "phytoene synthase activity" BROAD []
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0140631
name: aldehyde dehydrogenase (NAD+) inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+)." [PMID:33495566]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0140632
name: canonical inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex." [PMID:33420028, PMID:33420033, PMID:33542150]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0141084 ! inflammasome-mediated signaling pathway

[Term]
id: GO:0140633
name: CARD8 inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex." [PMID:33420028, PMID:33420033, PMID:33542150]
is_a: GO:0140632 ! canonical inflammasome complex assembly

[Term]
id: GO:0140634
name: CARD8 inflammasome complex
namespace: cellular_component
def: "An inflammasome complex that consists of CARD8 and CASP1." [PMID:33420028, PMID:33420033, PMID:33542150]
is_a: GO:0061702 ! canonical inflammasome complex

[Term]
id: GO:0140635
name: neutrophil dispersal
namespace: biological_process
def: "The movement of a neutrophil away from the site of wound or infection following its initial migration to the site." [PMID:31727891]
is_a: GO:1990266 ! neutrophil migration

[Term]
id: GO:0140636
name: copper import into the mitochondrion
namespace: biological_process
def: "The process in which copper is transported from the cytosol into the mitochondrial matrix." [PMID:32979421]
is_a: GO:0035434 ! copper ion transmembrane transport
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:0140638
name: small ribosomal subunit processing complex
namespace: cellular_component
def: "A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p." [GOC:lnp, PMID:21849504, PMID:25064857]
synonym: "small ribosomal subunit maturation complex" RELATED []
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0140639
name: positive regulation of pyroptotic inflammatory response
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a pyroptotic inflammatory response." [PMID:24626226]
synonym: "positive regulation of pyroptosis" BROAD []
is_a: GO:0050729 ! positive regulation of inflammatory response
relationship: positively_regulates GO:0070269 ! pyroptotic inflammatory response

[Term]
id: GO:0140640
name: catalytic activity, acting on a nucleic acid
namespace: molecular_function
def: "Catalytic activity that acts to modify a nucleic acid." [GOC:pg]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0140641
name: mitotic spindle formation (spindle phase two)
namespace: biological_process
def: "The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase." [PMID:32723864]
synonym: "metaphase spindle stability" EXACT []
synonym: "metaphase spindle stabilization" EXACT []
is_a: GO:0090307 ! mitotic spindle assembly

[Term]
id: GO:0140642
name: meiotic spindle formation (spindle phase two)
namespace: biological_process
def: "The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase." [PMID:32723864]
is_a: GO:0090306 ! meiotic spindle assembly

[Term]
id: GO:0140643
name: hydroxymethylglutaryl-CoA reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH." [PMID:29224355, RHEA:14833]
comment: Note that this activity is not present in eukaryotes, see PMID:29224355.
synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88]
synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88]
xref: EC:1.1.1.88
xref: KEGG_REACTION:R02081
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN
xref: RHEA:14833
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0140644
name: neutrophil extracellular trap
namespace: cellular_component
def: "Extracellular microbicidal structure composed of nuclear chromatin, histones and granular antimicrobial proteins. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms." [PMID:31172493]
synonym: "NET" BROAD []
is_a: GO:0043264 ! extracellular membraneless organelle

[Term]
id: GO:0140645
name: neutrophil extracellular trap formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a neutrophil extracellular trap, a network of extracellular fibers primarily composed of DNA from neutrophils, which bind and neutralizes pathogens." [PMID:28267716]
synonym: "NET formation" BROAD []
xref: http://purl.obolibrary.org/obo/TXPO_0002149
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0140646
name: negative regulation of pre-B cell receptor expression
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells." [PMID:22949502]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0002330 ! pre-B cell receptor expression

[Term]
id: GO:0140647
name: P450-containing electron transport chain
namespace: biological_process
def: "A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways." [PMID:16042601]
synonym: "P450-containing system" RELATED []
xref: Wikipedia:P450-containing_systems
is_a: GO:0022900 ! electron transport chain

[Term]
id: GO:0140648
name: positive regulation of cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [PMID:22375066]
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0110044 ! regulation of cell cycle switching, mitotic to meiotic cell cycle
relationship: positively_regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle

[Term]
id: GO:0140649
name: symbiont-mediated cell-to-cell migration by invasive hypha
namespace: biological_process
def: "The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of maximum hyphal constriction." [PMID:29567712]
comment: Do not confuse with ' GO:0036267 invasive filamentous growth ', which doesn't include invasion of cells within the host.
synonym: "cell-to-cell migration by invasive hypha" EXACT []
synonym: "host tissue colonization" BROAD []
synonym: "invasive growth" BROAD []
synonym: "invasive hyphae formation" EXACT []
synonym: "plant tissue colonization" BROAD []
is_a: GO:0106259 ! symbiont-mediated cell-to-cell migration in host

[Term]
id: GO:0140650
name: radial glia-guided pyramidal neuron migration
namespace: biological_process
def: "The radial migration of a pyramidal neuron along radial glial cells." [PMID:3760547]
synonym: "radial glia-dependent neuronal migration" EXACT []
is_a: GO:0001764 ! neuron migration

[Term]
id: GO:0140651
name: futile creatine cycle
namespace: biological_process
def: "The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis." [PMID:33597756, PMID:33981039]
is_a: GO:0008152 ! metabolic process
relationship: part_of GO:1990845 ! adaptive thermogenesis

[Term]
id: GO:0140652
name: pyripyropene A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyripyropene A." [GOC:ach, PMID:21224862, PMID:26019565]
synonym: "pyripyropene A anabolism" EXACT []
synonym: "pyripyropene A biosynthesis" EXACT []
synonym: "pyripyropene A formation" EXACT []
synonym: "pyripyropene A synthesis" EXACT []
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process

[Term]
id: GO:0140653
name: obsolete fumitremorgin C biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of the indole alkaloid fumitremorgin C." [GOC:ach, PMID:19226505]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "fumitremorgin C anabolism" EXACT []
synonym: "fumitremorgin C biosynthesis" EXACT []
synonym: "fumitremorgin C formation" EXACT []
synonym: "fumitremorgin C synthesis" EXACT []
is_obsolete: true
replaced_by: GO:1900772

[Term]
id: GO:0140654
name: tryprostatin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tryprostatin A." [GOC:ach, PMID:19226505]
synonym: "tryprostatin A anabolism" EXACT []
synonym: "tryprostatin A biosynthesis" EXACT []
synonym: "tryprostatin A formation" EXACT []
synonym: "tryprostatin A synthesis" EXACT []
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0140655
name: obsolete mitochondrial proliferation
namespace: biological_process
def: "OBSOLETE. The multiplication of mitochondria, resulting in the expansion of the number of mitochondria within a cell." [PMID:28301064]
comment: This term was obsoleted because it was not clearly defined and usage has been inconsistent.
is_obsolete: true
consider: GO:0007005

[Term]
id: GO:0140656
name: endodeoxyribonuclease activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an endodeoxyribonuclease." [PMID:33836577]
is_a: GO:0170053 ! nuclease activator activity

[Term]
id: GO:0140657
name: ATP-dependent activity
namespace: molecular_function
def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "ATP hydrolysis-dependent activity" EXACT []
synonym: "ATPase activity" EXACT []
synonym: "ATPase activity, coupled" EXACT []
synonym: "ATPase-dependent activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140658
name: ATP-dependent chromatin remodeler activity
namespace: molecular_function
alt_id: GO:0070615
def: "An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]
synonym: "ATP hydrolysis-dependent chromatin remodeler activity" EXACT []
synonym: "ATP-dependent chromatin remodeller activity" EXACT []
synonym: "ATP-dependent chromatin remodelling" RELATED []
synonym: "ATPase-dependent chromatin remodeler activity" EXACT []
synonym: "nucleosome-activated ATPase activity" RELATED [GOC:mah]
synonym: "nucleosome-dependent ATPase activity" RELATED []
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA

[Term]
id: GO:0140659
name: cytoskeletal motor regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a motor protein." [PMID:23142046, PMID:33221250]
synonym: "motor activity regulator activity" BROAD []
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0140660
name: cytoskeletal motor activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a motor protein." [PMID:33221250]
synonym: "motor activity activator activity" BROAD []
is_a: GO:0140659 ! cytoskeletal motor regulator activity
is_a: GO:0140677 ! molecular function activator activity

[Term]
id: GO:0140661
name: cytoskeletal motor inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of a motor protein." [PMID:23142046]
synonym: "motor activity inhibitor activity" BROAD []
is_a: GO:0140659 ! cytoskeletal motor regulator activity
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0140662
name: ATP-dependent protein folding chaperone
namespace: molecular_function
def: "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]
is_a: GO:0044183 ! protein folding chaperone
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0140663
name: ATP-dependent FeS chaperone activity
namespace: molecular_function
def: "Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis." [PMID:16843540]
is_a: GO:0016530 ! metallochaperone activity
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0140664
name: ATP-dependent DNA damage sensor activity
namespace: molecular_function
def: "A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]
synonym: "ATP-dependent DNA damage sensing activity" EXACT []
is_a: GO:0008094 ! ATP-dependent activity, acting on DNA
is_a: GO:0140612 ! DNA damage sensor activity

[Term]
id: GO:0140665
name: ATP-dependent H3-H4 histone complex chaperone activity
namespace: molecular_function
def: "A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis." [PMID:31848341, PMID:33658433]
synonym: "ATP-dependent H3-H4 histone complex loader activity" NARROW []
synonym: "H3-H4 dimer loading activity" EXACT []
synonym: "H3-H4 histone chaperone" BROAD []
synonym: "H3-H4 histone complex loader activity" BROAD []
synonym: "histone chaperone" RELATED []
synonym: "histone H3-H4 dimer loading activity" EXACT []
is_a: GO:0000510 ! H3-H4 histone complex chaperone activity
is_a: GO:0140674 ! ATP-dependent histone chaperone activity

[Term]
id: GO:0140666
name: annealing activity
namespace: molecular_function
alt_id: GO:0097617
def: "An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule." [PMID:22888405]
synonym: "renaturation" RELATED []
xref: Reactome:R-HSA-5686642 "RAD52 promotes single strand annealing at resected DNA DSBs"
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0140667
name: regulation of oxytocin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of oxytocin." [PMID:25096581]
is_a: GO:0010468 ! regulation of gene expression
relationship: regulates GO:0036162 ! oxytocin production

[Term]
id: GO:0140668
name: positive regulation of oxytocin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of oxytocin." [PMID:25096581]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0140667 ! regulation of oxytocin production
relationship: positively_regulates GO:0036162 ! oxytocin production

[Term]
id: GO:0140669
name: negative regulation of oxytocin production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of production of oxytocin." [PMID:25096581]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0140667 ! regulation of oxytocin production
relationship: negatively_regulates GO:0036162 ! oxytocin production

[Term]
id: GO:0140670
name: cohesin unloader activity
namespace: molecular_function
def: "Facilitating a conformational change to unload a cohesin complex from sister chromatids." [PMID:26687354]
synonym: "cohesin unloading activity" EXACT []
is_a: GO:0140097 ! catalytic activity, acting on DNA

[Term]
id: GO:0140671
name: ADA complex
namespace: cellular_component
def: "A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex." [GOC:bhm, PMID:21734642, PMID:28966424]
synonym: "ADA HAT complex" EXACT []
synonym: "ADA histone acetyltransferase complex" EXACT []
synonym: "Ada2/Gcn5/Ada3 transcription activator complex" RELATED []
synonym: "scADA" NARROW []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0140672
name: ATAC complex
namespace: cellular_component
def: "A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation." [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]
synonym: "Ada two A containing complex" EXACT []
synonym: "Ada Two-A containing complex" EXACT []
synonym: "Ada-Two-A-containing complex" EXACT []
synonym: "ADA2A-containing complex" EXACT []
synonym: "G-ATAC complex" EXACT []
synonym: "KAT2A-containing ATAC complex" EXACT []
synonym: "KAT2B-containing ATAC complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0140673
name: transcription elongation-coupled chromatin remodeling
namespace: biological_process
def: "A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation." [PMID:22922743, PMID:28053344]
comment: Note: Do not confuse with 'GO:0045815 transcriptional initiation-coupled chromatin remodeling', which describes the maintenance of chromatin in an open conformation, allowing the transcriptional machinery to access the DNA.
synonym: "chromatin maintenance during transcription elongation" RELATED []
synonym: "co-transcriptional chromatin reassembly" EXACT []
synonym: "DNA replication-independent chromatin organization" RELATED []
synonym: "euchromatin maintenance during transcription elongation" EXACT []
synonym: "maintenance of chromatin integrity during transcription elongation by RNAPII" EXACT []
synonym: "maintenance of transcriptionally active chromatin during transcription elongation" EXACT []
synonym: "transciptional elongation-coupled chromatin remodeling" EXACT []
synonym: "transcription elongation coupled chromatin remodeling" EXACT []
synonym: "transcriptional elongation-coupled chromatin remodeling" EXACT []
is_a: GO:0006338 ! chromatin remodeling
relationship: part_of GO:0006368 ! transcription elongation by RNA polymerase II

[Term]
id: GO:0140674
name: ATP-dependent histone chaperone activity
namespace: molecular_function
alt_id: GO:0140675
def: "Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis." [PMID:26459557]
synonym: "ATP-dependent histone loader activity" NARROW []
synonym: "ATP-dependent histone unloader activity" NARROW []
synonym: "histone loader activity" NARROW []
synonym: "histone loading activity" NARROW []
synonym: "histone unloader activity" NARROW []
synonym: "histone unloading activity" NARROW []
synonym: "nucleosome remodeling activity" RELATED []
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0140658 ! ATP-dependent chromatin remodeler activity
is_a: GO:0140713 ! histone chaperone activity

[Term]
id: GO:0140676
name: oscillatory cAMP signaling
namespace: biological_process
def: "Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate." [PMID:18657484]
synonym: "cAMP relay" EXACT []
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0140677
name: molecular function activator activity
namespace: molecular_function
def: "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0140678
name: molecular function inhibitor activity
namespace: molecular_function
def: "A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0140679
name: ABC-type sodium transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out)." [PMID:9106203]
xref: EC:7.2.2.4
xref: TC:3.A.1.115.1
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0019829 ! ATPase-coupled monoatomic cation transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0140680
name: histone H3K36me/H3K36me2 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:20531378]
synonym: "histone H3-di/monomethyl-lysine-36 demethylase activity" EXACT []
synonym: "histone H3K36me demethylase activity" RELATED []
synonym: "histone H3K36me2 demethylase activity" BROAD []
xref: EC:1.14.11.27
xref: MetaCyc:RXN-13186
xref: RHEA:42032
is_a: GO:0051864 ! histone H3K36 demethylase activity

[Term]
id: GO:0140681
name: histone H3K36me2/H3K36me3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:21914792]
synonym: "histone H3-tri/dimethyl-lysine-36 demethylase activity" EXACT []
synonym: "histone H3K36me2 demethylase activity" BROAD []
synonym: "histone H3K36me3 demethylase activity" RELATED []
xref: EC:1.14.11.69
xref: MetaCyc:RXN-20643
xref: RHEA:60236
is_a: GO:0051864 ! histone H3K36 demethylase activity

[Term]
id: GO:0140682
name: FAD-dependent H3K4me/H3K4me3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction." [PMID:22473470]
synonym: "histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity" EXACT []
synonym: "histone H3K4me demethylase activity" RELATED []
synonym: "histone H3K4me2 demethylase activity" BROAD []
xref: EC:1.14.99.66
xref: RHEA:60244
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0032453 ! histone H3K4 demethylase activity

[Term]
id: GO:0140683
name: histone H3K9me/H3K9me2 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16603238]
synonym: "histone H3-di/monomethyl-lysine-9 demethylase activity" EXACT []
synonym: "histone H3K9me demethylase activity" BROAD []
synonym: "histone H3K9me2 demethylase activity" BROAD []
xref: EC:1.14.11.65
xref: RHEA:60188
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0032454 ! histone H3K9 demethylase activity

[Term]
id: GO:0140684
name: histone H3K9me2/H3K9me3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:20208542, PMID:20531378]
synonym: "histone H3-tri/dimethyl-lysine-9 demethylase activity" EXACT []
synonym: "histone H3K9me2 demethylase activity" BROAD []
synonym: "histone H3K9me3 demethylase activity" RELATED []
xref: EC:1.14.11.66
xref: RHEA:60200
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0032454 ! histone H3K9 demethylase activity

[Term]
id: GO:0140685
name: FAD-dependent histone H3K9me/H3K9me2 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction." [PMID:22473470]
synonym: "histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity" EXACT []
synonym: "histone H3K9me demethylase activity" BROAD []
synonym: "histone H3K9me2 demethylase activity" BROAD []
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0032454 ! histone H3K9 demethylase activity

[Term]
id: GO:0140690
name: dihydropyrimidine dehydrogenase (NAD+) complex
namespace: cellular_component
def: "A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT." [PMID:21169495, PMID:34097066]
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0140691
name: RNA folding chaperone
namespace: molecular_function
def: "Binding to an RNA or an RNA-containing complex to assist the folding process." [PMID:31165735]
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140692
name: very long-chain fatty acid omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:16547005, RHEA:67952]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
xref: RHEA:67952
is_a: GO:0120250 ! fatty acid omega-hydroxylase activity

[Term]
id: GO:0140693
name: molecular condensate scaffold activity
namespace: molecular_function
def: "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081]
synonym: "phase separation nucleation activity" EXACT []
synonym: "phase separation nucleator activity" EXACT []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0140694
name: membraneless organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]
synonym: "non-membrane-bounded organelle assembly" EXACT []
synonym: "non-membrane-bounded organelle formation" EXACT []
synonym: "non-membrane-enclosed organelle assembly" EXACT []
synonym: "non-membrane-enclosed organelle formation" EXACT []
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0140696
name: (S)-2-hydroxyglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol." [PMID:30498244, RHEA:58664]
synonym: "L-2-hydroxyglutarate dehydrogenase activity" EXACT []
xref: EC:1.1.5.13
xref: RHEA:58664
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0140698
name: attachment of telomeric heterochromatin to nuclear envelope
namespace: biological_process
def: "The process in which physical connections are formed between sub-telomeric heterochromatin and the nuclear envelope facilitating bouquet formation." [PMID:31635174]
synonym: "attachment of telomeres to nuclear envelope" BROAD []
synonym: "attachment of telomeric chromatin to nuclear envelope" BROAD []
synonym: "heterochromatin organization" BROAD []
is_a: GO:0097240 ! chromosome attachment to the nuclear envelope

[Term]
id: GO:0140699
name: cyclic GMP-AMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [PMID:23258413]
comment: Note that this term should not be used for direct annotation. It should be possible to annotate to a more specific child term that describes the position of the phosphate group on the cGAMP molecule.
subset: gocheck_do_not_annotate
synonym: "cyclic-GMP-AMP synthase activity" EXACT []
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0140700
name: 3',2'-cyclic GMP-AMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP)." [PMID:34261127]
synonym: "3',2' cyclic-GMP-AMP synthase activity" EXACT []
synonym: "3',2'-cyclic GAMP synthase activity" EXACT []
is_a: GO:0140699 ! cyclic GMP-AMP synthase activity

[Term]
id: GO:0140701
name: 3',3'-cyclic GMP-AMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP)." [PMID:30787435, RHEA:35647]
synonym: "3',3' cyclic-GAMP synthase activity" EXACT []
synonym: "3',3' cyclic-GMP-AMP synthase activity" EXACT []
synonym: "3',3'-cyclic GAMP synthase activity" EXACT []
xref: RHEA:35647
is_a: GO:0140699 ! cyclic GMP-AMP synthase activity

[Term]
id: GO:0140702
name: cyclic GMP-AMP binding
namespace: molecular_function
def: "Binding to cyclic GMP-AMP (cGAMP) nucleotide." [PMID:23258412]
subset: gocheck_do_not_annotate
is_a: GO:0030551 ! cyclic nucleotide binding

[Term]
id: GO:0140703
name: 3',3'-cyclic GMP-AMP binding
namespace: molecular_function
def: "Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages." [PMID:30787435]
synonym: "3',3' cyclic-GMP-AMP binding" EXACT []
synonym: "3',3'-cGAMP binding" EXACT []
synonym: "3',3'-cGMP-AMP binding" EXACT []
synonym: "3',3'-cyclic GAMP binding" EXACT []
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0140702 ! cyclic GMP-AMP binding

[Term]
id: GO:0140704
name: 3',2'-cyclic GMP-AMP binding
namespace: molecular_function
def: "Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages." [PMID:34261127]
synonym: "3',2' cyclic-GMP-AMP binding" EXACT []
synonym: "3',2'-cGAMP binding" EXACT []
synonym: "3',2'-cyclic GAMP binding" EXACT []
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0140706
name: protein-containing complex localization to centriolar satellite
namespace: biological_process
def: "A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite." [PMID:27979967]
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0140707
name: chromatin-nuclear membrane anchor activity
namespace: molecular_function
def: "Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis." [PMID:24184107, PMID:31048766]
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0140708
name: CAT tailing
namespace: biological_process
def: "The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control system." [PMID:25554787, PMID:32934225]
is_a: GO:0002182 ! cytoplasmic translational elongation
relationship: part_of GO:0072344 ! rescue of stalled ribosome
relationship: part_of GO:1990116 ! ribosome-associated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0140709
name: Frizzled Nuclear Import pathway
namespace: biological_process
def: "A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface a the target cell results in internalization and cleavage of the frizzled receptor to yield a C-terminal fragment that is imported into the nucleus. The frizzled C-terminal fragment is incorporated into large ribonucleoprotein particles and stimulates their egress via nuclear budding." [PMID:22510459, PMID:22579286]
synonym: "FNI" BROAD []
synonym: "Frizzled Nuclear Import Wnt Pathway" EXACT []
is_a: GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:0140710
name: regulation of Frizzled Nuclear Import pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Frizzled Nuclear Import pathway." [PMID:22510459, PMID:22579286]
synonym: "regulation of FNI" BROAD []
synonym: "regulation of Frizzled Nuclear Import Wnt Pathway" EXACT []
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
relationship: regulates GO:0140709 ! Frizzled Nuclear Import pathway

[Term]
id: GO:0140711
name: positive regulation of Frizzled Nuclear Import pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a Frizzled Nuclear Import pathway." [PMID:22510459, PMID:22579286]
synonym: "positive regulation of FNI" BROAD []
synonym: "positive regulation of Frizzled Nuclear Import Wnt Pathway" EXACT []
is_a: GO:0140710 ! regulation of Frizzled Nuclear Import pathway
is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway
relationship: positively_regulates GO:0140709 ! Frizzled Nuclear Import pathway

[Term]
id: GO:0140712
name: negative regulation of Frizzled Nuclear Import pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a Frizzled Nuclear Import pathway." [PMID:22510459, PMID:22579286]
synonym: "negative regulation of FNI" BROAD []
synonym: "negative regulation of Frizzled Nuclear Import Wnt Pathway" EXACT []
is_a: GO:0140710 ! regulation of Frizzled Nuclear Import pathway
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
relationship: negatively_regulates GO:0140709 ! Frizzled Nuclear Import pathway

[Term]
id: GO:0140713
name: histone chaperone activity
namespace: molecular_function
def: "Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone)." [PMID:26459557]
synonym: "histone carrier activity" EXACT []
synonym: "nucleosome remodeling activity" RELATED []
xref: Reactome:R-HSA-9822185 "HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA"
is_a: GO:0140597 ! protein carrier chaperone

[Term]
id: GO:0140714
name: large ribosomal subunit pre-assembly complex
namespace: cellular_component
def: "A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae)." [GOC:lnp, PMID:17145778, PMID:9528757]
is_a: GO:0101031 ! protein folding chaperone complex

[Term]
id: GO:0140715
name: serine-tRNA ligase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex that catalyzes the ligation of serine to tRNA(Ser), forming L-seryl-tRNA(Ser)." [PMID:30943413]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0140717
name: entry into host through the stromata
namespace: biological_process
def: "Entry of a symbiont into host plant tissue via the stromata, microscopic pores in the epidermis of the aerial parts of terrestrial plants. These pores are essential for photosynthesis, as they allow CO2 to diffuse into the plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16959560, PMID:17419713, PMID:29307013]
is_a: GO:0044409 ! symbiont entry into host

[Term]
id: GO:0140718
name: facultative heterochromatin formation
namespace: biological_process
def: "The compaction of chromatin into a conformation that is refractory to transcription but that can be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). In metazoa, this involves the methylation of histone H3K27." [PMID:17936700]
comment: Note that facultative heterochromatin can be reprogrammed, as opposed to constitutive heterochromatin which usually cannot be reprogrammed to a transcriptionally-competent state. Note also that facultative heterochromatin formation does not usually involve DNA methylation, while constitutive heterochromatin formation does.
synonym: "facultative heterochromatin assembly" EXACT []
synonym: "fHC assembly" EXACT []
is_a: GO:0031507 ! heterochromatin formation

[Term]
id: GO:0140719
name: constitutive heterochromatin formation
namespace: biological_process
def: "The compaction of chromatin into heterochromatin, a conformation that is refractory to transcription. Constitutive heterochromatin cannot be converted back to euchromatin, the transcriptionally-active conformation. In metazoa, this involves the methylation of histone H3K9." [PMID:17936700]
comment: Note that constitutive heterochromatin usually cannot be reprogrammed to a transcriptionally-competent state, as opposed to facultative heterochromatin, which can be reprogrammed. Note also that constitutive usually involves DNA methylation, while facultative heterochromatin formation does not.
synonym: "constitutive heterochromatin assembly" EXACT []
is_a: GO:0031507 ! heterochromatin formation

[Term]
id: GO:0140720
name: subtelomeric heterochromatin
namespace: cellular_component
def: "Heterochromatin that is located adjacent to the telomere, and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3)." [PMID:34576871]
is_a: GO:0000792 ! heterochromatin
relationship: part_of GO:0099115 ! chromosome, subtelomeric region

[Term]
id: GO:0140721
name: nuclease inhibitor activity
namespace: molecular_function
def: "Binds to and modulates the activity of a nuclease." [PMID:28785032, PMID:29554913, PMID:30046034]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0140722
name: mycophenolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mycophenolic acid (MPA). MPA is the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893." [PMID:21398490, PMID:26751579, PMID:31209052]
synonym: "MPA anabolism" BROAD []
synonym: "MPA biosynthesis" BROAD []
synonym: "MPA formation" BROAD []
synonym: "MPA synthesis" BROAD []
synonym: "mycophenolic acid anabolism" EXACT []
synonym: "mycophenolic acid biosynthesis" EXACT []
synonym: "mycophenolic acid formation" EXACT []
synonym: "mycophenolic acid synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0140723
name: patulin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria." [PMID:25120234, PMID:30680886]
synonym: "patulin anabolism" EXACT []
synonym: "patulin biosynthesis" EXACT []
synonym: "patulin formation" EXACT []
synonym: "patulin synthesis" EXACT []
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0140724
name: positive regulation of patulin biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of patulin." [PMID:25625822]
synonym: "positive regulation of patulin anabolism" EXACT []
synonym: "positive regulation of patulin formation" EXACT []
synonym: "positive regulation of patulin synthesis" EXACT []
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0140723 ! patulin biosynthetic process

[Term]
id: GO:0140725
name: detoxification of free heme
namespace: biological_process
def: "Any process that reduces or removes the toxicity of free heme. These include transport of heme away from sensitive areas and to compartments or complexes whose purpose is sequestration of heme." [PMID:26741528, PMID:32983129]
synonym: "free heme detoxification" EXACT []
is_a: GO:0098754 ! detoxification

[Term]
id: GO:0140727
name: siRNA-mediated pericentric heterochromatin formation
namespace: biological_process
def: "The formation of pericentric heterochromatin by a process mediated by a small interfering RNA (siRNA)." [PMID:15289661]
synonym: "RNAi-mediated heterochromatin assembly at centromere" EXACT []
synonym: "siRNA dependent pericentric heterochromatin assembly" EXACT []
synonym: "siRNA-dependent pericentric heterochromatin assembly" EXACT []
synonym: "siRNA-dependent pericentric heterochromatin formation" EXACT []
is_a: GO:0031508 ! pericentric heterochromatin formation
is_a: GO:0141194 ! siRNA-mediated heterochromatin formation

[Term]
id: GO:0140728
name: GC-box binding
namespace: molecular_function
def: "Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site." [PMID:14701757]
synonym: "GC box binding" EXACT []
synonym: "GC rich promoter region binding" BROAD []
synonym: "GC-rich region binding" BROAD []
synonym: "GC_rich_promoter_region binding" BROAD []
is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding

[Term]
id: GO:0140729
name: self-resistance to endogenously produced metabolite
namespace: biological_process
def: "A process that reduces or removes the toxicity of an endogenously produced substance. Mechanisms of resistance to endogenously produced compounds include modification the compound, export, sequestration, or mutations in the target enzyme." [PMID:21923907, PMID:29763292]
synonym: "prevention of self-toxicity" EXACT []
synonym: "self-resistance to bioactive secondary metabolite" EXACT []
synonym: "self-resistance to endogenously produced compound" EXACT []
synonym: "self-resistance to endogenously produced toxin" EXACT []
is_a: GO:0098754 ! detoxification

[Term]
id: GO:0140730
name: amphiregulin production
namespace: biological_process
def: "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor." [PMID:24463227]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "AREG production" BROAD []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0140731
name: regulation of amphiregulin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of amphiregulin." [PMID:24463227]
synonym: "regulation of AREG production" BROAD []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0140730 ! amphiregulin production

[Term]
id: GO:0140732
name: positive regulation of amphiregulin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of amphiregulin." [PMID:24463227]
synonym: "positive regulation of AREG production" BROAD []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0140731 ! regulation of amphiregulin production
relationship: positively_regulates GO:0140730 ! amphiregulin production

[Term]
id: GO:0140733
name: tRNA ligase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a tRNA ligase." [PMID:30943413]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0055103 ! ligase regulator activity

[Term]
id: GO:0140734
name: ammonium excretion
namespace: biological_process
def: "The elimination of ammonium ions from an excretory cell." [PMID:25740900]
synonym: "ammonia excretion" RELATED []
is_a: GO:0007588 ! excretion

[Term]
id: GO:0140735
name: lovastatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)." [PMID:10334994, PMID:10381407]
synonym: "lovastatin anabolism" EXACT []
synonym: "lovastatin biosynthesis" EXACT []
synonym: "lovastatin formation" EXACT []
synonym: "lovastatin synthesis" EXACT []
synonym: "mevacor anabolism" EXACT []
synonym: "mevacor biosynthesis" EXACT []
synonym: "mevacor biosynthetic process" EXACT []
synonym: "mevacor formation" EXACT []
synonym: "mevacor synthesis" EXACT []
synonym: "mevinolin anabolism" EXACT []
synonym: "mevinolin biosynthesis" EXACT []
synonym: "mevinolin biosynthetic process" EXACT []
synonym: "mevinolin formation," EXACT []
synonym: "mevinolin synthesis" EXACT []
synonym: "monacolin K anabolism" EXACT []
synonym: "monacolin K biosynthesis" EXACT []
synonym: "monacolin K biosynthetic process" EXACT []
synonym: "monacolin K formation" EXACT []
synonym: "monacolin K synthesis" EXACT []
xref: kegg.module:M00893
xref: MetaCyc:PWY-7535
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process

[Term]
id: GO:0140736
name: positive regulation of lovastatin biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of lovastin." [PMID:10334994, PMID:19781329]
synonym: "positive regulation of mevacor biosynthetic process" EXACT []
synonym: "positive regulation of mevinolin biosynthetic process" EXACT []
synonym: "positive regulation of monacolin K biosynthetic process" EXACT []
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
relationship: positively_regulates GO:0140735 ! lovastatin biosynthetic process

[Term]
id: GO:0140737
name: encapsulin nanocompartment
namespace: cellular_component
def: "Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla." [PMID:32918485]
synonym: "protein nanocompartment" BROAD []
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0140738
name: NLRP6 inflammasome complex
namespace: cellular_component
def: "An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11." [PMID:30674671, PMID:34678144]
is_a: GO:0061702 ! canonical inflammasome complex

[Term]
id: GO:0140739
name: NLRP6 inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex." [PMID:30674671, PMID:34678144]
is_a: GO:0140632 ! canonical inflammasome complex assembly

[Term]
id: GO:0140740
name: ADP-riboxanase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4(+) + nicotinamide." [PMID:34671164, RHEA:69500]
comment: Note that this activity has two steps: a transfer of an ADP-ribose group, followed by the elimination of an ammonia group.
xref: RHEA:69500
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups
is_a: GO:0016841 ! ammonia-lyase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140741
name: tRNA-uracil-4 sulfurtransferase activity
namespace: molecular_function
def: "Catalyzes the reaction: ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster = AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster." [PMID:27791189, PMID:5541999, RHEA:24176]
synonym: "tRNA U4 sulfurtransferase" EXACT []
synonym: "tRNA uracil 4 sulfurtransferase" EXACT []
synonym: "tRNA uracil 4-sulfurtransferase" EXACT []
xref: EC:2.8.1.4
xref: MetaCyc:RXN-18388
xref: RHEA:24176
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0140742
name: lncRNA transcription
namespace: biological_process
def: "The transcription of lncRNAs, non-coding RNAs over 200 nucleotides in length, from a DNA template." [PMID:33767452, PMID:33913806]
is_a: GO:0006351 ! DNA-templated transcription

[Term]
id: GO:0140743
name: regulation of lncRNA transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of a lncRNA." [PMID:33767452, PMID:33913806]
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0140742 ! lncRNA transcription

[Term]
id: GO:0140744
name: negative regulation of lncRNA transcription
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of a lncRNA." [PMID:33767452, PMID:33913806]
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
is_a: GO:0140743 ! regulation of lncRNA transcription
relationship: negatively_regulates GO:0140742 ! lncRNA transcription

[Term]
id: GO:0140745
name: siRNA transcription
namespace: biological_process
def: "The transcription of a small interfering RNA from an RNA template." [PMID:23001036]
is_a: GO:0001172 ! RNA-templated transcription

[Term]
id: GO:0140746
name: siRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of small interfering RNA transcripts (siRNAs)." [PMID:25928405]
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0140747
name: obsolete regulation of ncRNA transcription
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template." [GOC:pg]
comment: The reason for obsoletion is that this term was added in error.
is_obsolete: true

[Term]
id: GO:0140748
name: positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process." [PMID:19189958]
is_a: GO:0060624 ! regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0060635 ! positive regulation of (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0140749
name: phlorizin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin." [PMID:9762914, RHEA:69639]
xref: RHEA:69639
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0140750
name: nucleosome array spacer activity
namespace: molecular_function
def: "A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair." [PMID:11683384, PMID:16468993]
comment: In Drosphila, this is mediated by ISWI, in human, by SMARCA5 and in S. cerevisiae by ISW1 and and ISW2.
synonym: "nucleosome array spacing activity" EXACT []
is_a: GO:0140751 ! histone octamer slider activity

[Term]
id: GO:0140751
name: histone octamer slider activity
namespace: molecular_function
def: "A chromatin remodeler activity that slides core histone octamers along chromosomal DNA." [PMID:10466730]
comment: This activity is mediated by at least three subfamilies of the SNF2 remodellers, namely the bromodomain domain, the chromodomain containing and the imitation switch subfamilies.
synonym: "histone octamer sliding activity" EXACT []
is_a: GO:0140658 ! ATP-dependent chromatin remodeler activity

[Term]
id: GO:0140752
name: branched 1,3-beta-D-glucan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1)." [PMID:34959732]
is_a: GO:0003843 ! 1,3-beta-D-glucan synthase activity

[Term]
id: GO:0140753
name: linear 1,3-beta-D-glucan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1)." [PMID:34959732]
is_a: GO:0003843 ! 1,3-beta-D-glucan synthase activity

[Term]
id: GO:0140754
name: reorganization of cellular membranes to establish viral sites of replication
namespace: biological_process
def: "A process in intracellular membranes are reorganized by viral proteins that perturb membrane integrity and can cause an extensive rearrangement of cellular membranes, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus." [PMID:19376974]
is_a: GO:0141171 ! symbiont-mediated perturbation of host membrane

[Term]
id: GO:0140755
name: reorganization of host cellular membranes to establish sites of replication
namespace: biological_process
def: "A process in which a virus triggers host intracellular membranes to be reorganized, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus." [PMID:34699787, PMID:4372566]
is_a: GO:0016032 ! viral process
is_a: GO:0141171 ! symbiont-mediated perturbation of host membrane

[Term]
id: GO:0140756
name: structural constituent of proteasome
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the proteasome." [PMID:10500111, PMID:28525752, PMID:28583440, PMID:29652515]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0140757
name: cysteine-type deNEDDylase activity
namespace: molecular_function
def: "An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated." [PMID:25628956]
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0019784 ! deNEDDylase activity

[Term]
id: GO:0140758
name: metal-dependent deNEDDylase activity
namespace: molecular_function
def: "An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated." [PMID:25628956]
is_a: GO:0008237 ! metallopeptidase activity
is_a: GO:0019784 ! deNEDDylase activity

[Term]
id: GO:0140759
name: histone H3K56 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein." [PMID:23451023, PMID:28743002]
synonym: "histone H3K56 methylase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K56 specific)" EXACT []
synonym: "histone methyltransferase activity (H3-K56 specific)" EXACT []
synonym: "histone-H3K56 methyltransferase activity" EXACT []
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0140760
name: histone H3K56me2/H3K56me3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein." [PMID:23451023, PMID:28743002]
synonym: "histone demethylase activity (H3-K56 specific)" RELATED []
synonym: "histone H3-tri/dimethyl-lysine-56 demethylase activity" EXACT []
synonym: "histone H3K56me2 demethylase activity" RELATED []
synonym: "histone H3K56me3 demethylase activity" RELATED []
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0141052 ! histone H3 demethylase activity

[Term]
id: GO:0140761
name: calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin." [PMID:15901640]
synonym: "calcium- and calmodulin-regulated 3',5'-cyclic-AMP phosphodiesterase activity" BROAD []
synonym: "calcium- and calmodulin-regulated AMP-specific phosphodiesterase activity" EXACT []
synonym: "calcium- and calmodulin-regulated cAMP phosphodiesterase activity" RELATED []
synonym: "calcium- and calmodulin-regulated cyclic-AMP phosphodiesterase activity" EXACT []
synonym: "calcium/calmodulin-regulated cAMP-specific phosphodiesterase activity" EXACT []
is_a: GO:0004115 ! 3',5'-cyclic-AMP phosphodiesterase activity

[Term]
id: GO:0140762
name: glucose dehydrogenase (FAD, quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone." [RHEA:47372]
xref: EC:1.1.5.9
xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:47372
is_a: GO:0004344 ! glucose dehydrogenase activity
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0140763
name: programmed DNA elimination by elimination of internal DNA segments
namespace: biological_process
def: "A programmed DNA elimination mechanism in which specific sequences, namely, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the genome. This process is known to occur in ciliates." [PMID:18708581]
is_a: GO:0031049 ! programmed DNA elimination

[Term]
id: GO:0140764
name: small RNA binding translational repressor activity
namespace: molecular_function
def: "A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA." [PMID:27184117, PMID:34117606]
comment: This term is intended for activities such as that mediated by argonaute in the RISC complex, that bring a miRNA or an siRNA to their target mRNA.
is_a: GO:0030371 ! translation repressor activity

[Term]
id: GO:0140765
name: histone H3K56 deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + NAD+ + H2O = histone H3 L-lysine (position 56) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K56 to NAD, producing nicotinamide." [PMID:23911928, PMID:30374165]
synonym: "NAD-dependent histone deacetylase activity (H3-K56 specific)" EXACT []
synonym: "NAD-dependent histone H3-K56 deacetylase activity" EXACT []
synonym: "NAD-dependent histone H3K56 deacetylase activity" EXACT []
is_a: GO:0017136 ! histone deacetylase activity, NAD-dependent
is_a: GO:0141050 ! histone H3K deacetylase activity

[Term]
id: GO:0140766
name: siRNA-mediated post-transcriptional gene silencing
namespace: biological_process
def: "A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants." [PMID:26372022]
synonym: "gene silencing by siRNA" EXACT []
synonym: "post-transcriptional gene silencing by siRNA" EXACT []
synonym: "posttranscriptional gene silencing by siRNA" EXACT []
synonym: "siRNA-mediated gene silencing" BROAD []
synonym: "siRNA-mediated PTGS" EXACT []
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:0140767
name: enzyme-substrate adaptor activity
namespace: molecular_function
def: "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446]
synonym: "protein substrate chaperone activity" RELATED []
synonym: "protein-substrate adaptor activity" BROAD []
xref: Reactome:R-HSA-202137 "AKT1 binds eNOS complex via HSP90"
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0140768
name: protein ADP-ribosyltransferase-substrate adaptor activity
namespace: molecular_function
def: "An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate." [PMID:32028527]
is_a: GO:0140767 ! enzyme-substrate adaptor activity

[Term]
id: GO:0140769
name: ACP-dependent peptidyl-lysine N6-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H+ + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]." [PMID:32461253, RHEA:70611]
xref: RHEA:70611
is_a: GO:0018030 ! peptidyl-lysine N6-myristoyltransferase activity

[Term]
id: GO:0140770
name: CoA-dependent peptidyl-lysine N6-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-[protein]." [PMID:1402651, RHEA:59752]
xref: RHEA:59752
is_a: GO:0018030 ! peptidyl-lysine N6-myristoyltransferase activity

[Term]
id: GO:0140771
name: ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H+ + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]." [PMID:32461253, RHEA:70615]
xref: RHEA:70615
is_a: GO:0018031 ! peptidyl-lysine N6-palmitoyltransferase activity

[Term]
id: GO:0140772
name: CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-[protein]." [PMID:30061757]
is_a: GO:0018031 ! peptidyl-lysine N6-palmitoyltransferase activity

[Term]
id: GO:0140773
name: NAD-dependent protein demyristoylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:23552949, RHEA:70567]
xref: RHEA:70567
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0140774
name: NAD-dependent protein depalmitoylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:23552949, RHEA:70563]
xref: RHEA:70563
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0140775
name: actin filament debranching activity
namespace: molecular_function
def: "Binding to an actin filament and promoting the dissociation of an actin filament branch." [PMID:20362448]
synonym: "actin debranching activity" EXACT []
is_a: GO:0140776 ! protein-containing complex destabilizing activity

[Term]
id: GO:0140776
name: protein-containing complex destabilizing activity
namespace: molecular_function
def: "A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex." [PMID:23727094, PMID:29779865, PMID:34836783]
synonym: "protein unfoldase activity" BROAD []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140777
name: protein-containing complex stabilizing activity
namespace: molecular_function
def: "A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex." [PMID:34040253]
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140778
name: microtubule stabilizing activity
namespace: molecular_function
def: "A protein-containing complex stabilizing activity that prevents dissociation of microtubules." [PMID:34970964]
is_a: GO:0140777 ! protein-containing complex stabilizing activity

[Term]
id: GO:0140779
name: XCL1 production
namespace: biological_process
def: "The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [PMID:7973732]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "lymphotactin production" EXACT []
xref: Wikipedia:XCL1
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0140780
name: obsolete modulation by symbiont of host system process
namespace: biological_process
def: "OBSOLETE. The process in which a symbiont organism effects a change in an anatomical system process of its host organism." [GOC:pg]
comment: This term was obsoleted because it is not sufficiently precise.
is_obsolete: true

[Term]
id: GO:0140781
name: ilicicolin H biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ilicicolin H, a 4-hydroxy-2-pyridone alkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain." [PMID:30905148, PMID:31216742, PMID:34947016]
synonym: "ilicicolin H anabolism" EXACT []
synonym: "ilicicolin H biosynthesis" EXACT []
synonym: "ilicicolin H formation" EXACT []
synonym: "ilicicolin H synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0140782
name: novofumigatonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety." [PMID:29968715]
synonym: "novofumigatonin anabolism" EXACT []
synonym: "novofumigatonin biosynthesis" EXACT []
synonym: "novofumigatonin formation" EXACT []
synonym: "novofumigatonin synthesis" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0140783
name: (M)-viriditoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (M)-viriditoxin, a fungal secondary metabolite with antibacterial activity." [PMID:31045362, PMID:31304040]
synonym: "(M)-viriditoxin anabolism" EXACT []
synonym: "(M)-viriditoxin biosynthesis" EXACT []
synonym: "(M)-viriditoxin formation" EXACT []
synonym: "(M)-viriditoxin synthesis" EXACT []
synonym: "viriditoxin anabolism" BROAD []
synonym: "viriditoxin biosynthesis" BROAD []
synonym: "viriditoxin formation" BROAD []
synonym: "viriditoxin synthesis" BROAD []
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0140784
name: metal ion sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion." [GOC:pg]
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0140785
name: amino acid sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid." [GOC:pg]
synonym: "amino acid sensing activity" EXACT []
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0140786
name: glutamine sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine." [PMID:34535752]
synonym: "glutamine sensing activity" EXACT []
is_a: GO:0140785 ! amino acid sensor activity

[Term]
id: GO:0140787
name: phosphate ion uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [PMID:29642010]
is_a: GO:0005315 ! phosphate transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity

[Term]
id: GO:0140788
name: L-glutamate uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [PMID:27133463, PMID:29642010]
synonym: "glutamate uniporter activity" BROAD []
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity

[Term]
id: GO:0140789
name: histone phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate." [PMID:19351884]
is_a: GO:0004721 ! phosphoprotein phosphatase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0140790
name: obsolete histone serine/threonine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: histone serine phosphate + H2O = histone serine + phosphate, and histone threonine phosphate + H2O = histone threonine + phosphate." [PMID:18614045]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0140789

[Term]
id: GO:0140791
name: histone H2AXS140 phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate." [PMID:18614045]
synonym: "histone H2-S140 serine phosphatase activity" EXACT []
synonym: "histone H2S140 phosphatase activity" RELATED []
synonym: "histone serine phosphatase activity (H2-S140 specific)" EXACT []
is_a: GO:0140789 ! histone phosphatase activity

[Term]
id: GO:0140792
name: obsolete histone tyrosine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: histone tyrosine phosphate + H2O = histone tyrosine + phosphate." [PMID:19234442, PMID:19351884]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
replaced_by: GO:0140789

[Term]
id: GO:0140793
name: histone H2AXY142 phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate." [PMID:19234442, PMID:19351884]
synonym: "histone H2-Y142 phosphatase activity" EXACT []
synonym: "histone H2Y142 phosphatase activity" RELATED []
synonym: "histone tyrosine phosphatase activity (H2-Y142 specific)" EXACT []
is_a: GO:0140789 ! histone phosphatase activity

[Term]
id: GO:0140794
name: histone arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination." [PMID:15339660]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "histone citrullination" RELATED []
synonym: "histone-arginine deiminase activity" EXACT []
is_a: GO:0004668 ! protein-arginine deiminase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0140795
name: histone H3R2 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone H3 L-arginyl (position 2)= histone H3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2." [PMID:15339660]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "H3-R2 citrullination" EXACT []
synonym: "histone H3-R2 arginine deiminase activity" EXACT []
synonym: "histone-arginine deiminase activity (H3-R2 specific)" EXACT []
is_a: GO:0141057 ! histone H3 arginine deiminase activity

[Term]
id: GO:0140796
name: histone H3R8 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8." [PMID:15339660]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "H3-R8 citrullination" EXACT []
synonym: "histone H3-R8 arginine deiminase activity" EXACT []
synonym: "histone-arginine deiminase activity (H3-R8 specific)" EXACT []
is_a: GO:0141057 ! histone H3 arginine deiminase activity

[Term]
id: GO:0140797
name: histone H3R17 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17." [PMID:15339660]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "H3-R17 citrullination" EXACT []
synonym: "histone H3-R17 arginine deiminase activity" EXACT []
synonym: "histone-arginine deiminase activity (H3-R17 specific)" EXACT []
is_a: GO:0141057 ! histone H3 arginine deiminase activity

[Term]
id: GO:0140798
name: histone H3R26 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone H3 L-arginyl (position 26)= histone H3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26." [PMID:15339660]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "H3-R26 citrullination" EXACT []
synonym: "histone H3-R26 arginine deiminase activity" EXACT []
synonym: "histone-arginine deiminase activity (H3-R26 specific)" EXACT []
is_a: GO:0141057 ! histone H3 arginine deiminase activity

[Term]
id: GO:0140799
name: glycine:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out)." [PMID:16701208, PMID:26912364]
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015187 ! glycine transmembrane transporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0140800
name: gamma-aminobutyric acid:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out)." [PMID:16701208, PMID:26912364, PMID:27601664]
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0140801
name: histone H2AXY142 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX." [PMID:19092802]
synonym: "gamma-H2AX-S142 kinase activity" EXACT []
synonym: "histone H2AX-Y142 kinase activity" EXACT []
synonym: "histone H2AY142 kinase activity" RELATED []
synonym: "histone kinase activity (H2AX-Y142 specific)" EXACT []
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0141003 ! histone H2AX kinase activity

[Term]
id: GO:0140802
name: NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide." [PMID:28525742, RHEA:58268]
xref: RHEA:58268
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140803
name: NAD+-protein-cysteine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]." [PMID:25043379, RHEA:56612]
xref: RHEA:56612
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140804
name: NAD+-protein-lysine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide." [PMID:25043379, RHEA:58220]
xref: RHEA:58220
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140805
name: NAD+-protein-serine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]." [PMID:32028527, PMID:33186521, RHEA:58232]
xref: RHEA:58232
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140806
name: NAD+-protein-aspartate ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide." [PMID:19764761, PMID:25043379, RHEA:54424]
xref: RHEA:54424
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140807
name: NAD+-protein-glutamate ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide." [PMID:19764761, PMID:25043379, RHEA:58224]
xref: RHEA:58224
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140808
name: NAD+-protein-tyrosine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]." [PMID:29954836, PMID:30257210, RHEA:58236]
xref: RHEA:58236
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140809
name: histone H4R3 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3." [PMID:16567635]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "H4-R3 citrullination" EXACT []
synonym: "histone H4-R3 arginine deiminase activity" EXACT []
synonym: "histone-arginine deiminase activity (H4-R3 specific)" EXACT []
is_a: GO:0140794 ! histone arginine deiminase activity

[Term]
id: GO:0140810
name: histone H1R54 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone H1 L-arginyl (position 54)= histone H1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54." [PMID:24463520]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "H1-R54 citrullination" EXACT []
synonym: "histone H1-R54 deiminase activity" EXACT []
synonym: "histone-arginine deiminase activity (H1-R54 specific)" EXACT []
is_a: GO:0140794 ! histone arginine deiminase activity

[Term]
id: GO:0140811
name: histone H2AR3 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3." [PMID:15823041]
comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
synonym: "H2A-R3 citrullination" EXACT []
synonym: "histone H2A-R3 arginine deiminase activity" EXACT []
synonym: "histone-arginine deiminase activity (H2A-R3 specific)" EXACT []
is_a: GO:0140794 ! histone arginine deiminase activity

[Term]
id: GO:0140812
name: orotate:monoatomic anion antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out)." [PMID:21350910, PMID:35144162]
synonym: "orotate:anion antiporter activity" BROAD []
synonym: "orotate:organic anion antiporter activity" NARROW []
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0140813
name: urate:monoatomic anion antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out)." [PMID:12024214, PMID:18411268]
synonym: "urate:anion antiporter activity" BROAD []
synonym: "urate:organic anion antiporter activity" NARROW []
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0140814
name: glycine betaine:sodium:chloride symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in)." [PMID:10358010]
synonym: "sodium/chloride-dependent glycine betaine transporter activity" BROAD []
xref: RHEA:71175
is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity

[Term]
id: GO:0140815
name: NAD+-protein-histidine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide." [PMID:35393539, RHEA:72071]
xref: RHEA:72071
is_a: GO:1990404 ! NAD+-protein ADP-ribosyltransferase activity

[Term]
id: GO:0140816
name: NAD+-histone H2BS6 serine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B." [PMID:34874266]
synonym: "NAD+-histone H2B-S6 serine ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+-histone-serine ADP-ribosyltransferase activity (H2B-S6 specific)" EXACT []
is_a: GO:0140805 ! NAD+-protein-serine ADP-ribosyltransferase activity

[Term]
id: GO:0140817
name: NAD+-histone H3S10 serine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3." [PMID:34874266]
synonym: "NAD+-histone H3-S10 serine ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+-histone-serine ADP-ribosyltransferase activity (H3-S10 specific)" EXACT []
is_a: GO:0140805 ! NAD+-protein-serine ADP-ribosyltransferase activity

[Term]
id: GO:0140818
name: mRNA 5'-triphosphate monophosphatase activity
namespace: molecular_function
def: "A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate." [PMID:9473487]
synonym: "mRNA 5'-phosphatase activity" EXACT []
xref: EC:3.6.1.74
xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN
xref: RHEA:67004
is_a: GO:0016462 ! pyrophosphatase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA

[Term]
id: GO:0140819
name: UDP-beta-L-arabinofuranose transporter activity
namespace: molecular_function
def: "Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other." [PMID:28373556]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0140820
name: cytosol to Golgi apparatus transport
namespace: biological_process
def: "The directed movement of substances from the cytosol into the Golgi apparatus of a cell." [PMID:28373556]
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0140821
name: UDP-beta-L-arabinofuranose import into Golgi lumen
namespace: biological_process
def: "The directed movement of UDP-beta-L-arabinofuranose from the cytosol to the Golgi apparatus of a cell." [PMID:28373556]
synonym: "cytosol to Golgi apparatus UDP-beta-L-arabinofuranose transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport
is_a: GO:0140820 ! cytosol to Golgi apparatus transport

[Term]
id: GO:0140822
name: NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue)." [PMID:32822587]
synonym: "NAD+-histone H2B-E35 glutamate ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E35 specific)" EXACT []
is_a: GO:0140807 ! NAD+-protein-glutamate ADP-ribosyltransferase activity

[Term]
id: GO:0140823
name: histone H2BS36 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B." [PMID:32822587]
synonym: "histone H2B-S36 kinase activity" EXACT []
synonym: "histone kinase activity (H2B-S36 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140998 ! histone H2B kinase activity

[Term]
id: GO:0140824
name: thioredoxin-dependent peroxiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O." [PMID:12707274, PMID:19820102, RHEA:62620]
xref: EC:1.11.1.24
xref: RHEA:62620
is_a: GO:0051920 ! peroxiredoxin activity

[Term]
id: GO:0140825
name: lactoperoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O." [PMID:19339248, RHEA:56136]
synonym: "peroxidase activity" BROAD []
xref: EC:1.11.1.7
xref: MetaCyc:PEROXID-RXN
xref: RHEA:56136
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0140826
name: zinc:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of zinc from one side of a membrane to the other according to the reaction: H+(out) + Zn2+(in) = H+(in) + Zn2+(out)." [PMID:19366695, PMID:30893306]
comment: Some transporters exchange 1 H+ for a Zn2+ while others are electroneutral and exchange 2 H+.
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0051139 ! metal cation:proton antiporter activity

[Term]
id: GO:0140827
name: zinc chaperone activity
namespace: molecular_function
def: "Binding to and delivering zinc ions to a target protein." [PMID:35584675]
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0140828
name: metal cation:monoatomic cation antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out)." [GOC:pg]
synonym: "solute:metal cation antiporter activity" BROAD []
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0140829
name: bicarbonate:monoatomic anion antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in)." [PMID:12440690]
synonym: "bicarbonate:anion antiporter activity" BROAD []
synonym: "hydrogencarbonate:monoatomic anion antiporter activity" EXACT []
xref: TC:2.A.31.1.1
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0140830
name: L-glutamine, sodium:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-glutamine(out) + Na+(out) = H+(out) + L-glutamine(in) + Na+(in)." [PMID:10619430, PMID:11742981, PMID:11850497]
xref: RHEA:71127
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity
is_a: GO:0015385 ! sodium:proton antiporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0140831
name: L-asparagine, sodium:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in)." [PMID:10619430, PMID:11742981]
xref: RHEA:71131
is_a: GO:0015182 ! L-asparagine transmembrane transporter activity
is_a: GO:0015385 ! sodium:proton antiporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0140832
name: L-histidine, sodium:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-histidine(out) + Na+(out) = H+(out) + L-histidine(in) + Na+(in)." [PMID:10619430, PMID:11742981]
xref: RHEA:71135
is_a: GO:0005290 ! L-histidine transmembrane transporter activity
is_a: GO:0015385 ! sodium:proton antiporter activity
is_a: GO:0045119 ! azole:proton antiporter activity
is_a: GO:0140848 ! amino acid:monoatomic cation antiporter activity

[Term]
id: GO:0140833
name: RNA polymerase II CTD heptapeptide repeat Y1 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1)." [PMID:28248323]
synonym: "RNA polymerase II C-terminal domain Y1 kinase activity" EXACT []
is_a: GO:0008353 ! RNA polymerase II CTD heptapeptide repeat kinase activity

[Term]
id: GO:0140834
name: RNA polymerase II CTD heptapeptide repeat S2 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2)." [PMID:28248323]
synonym: "RNA polymerase II C-terminal domain S2 kinase activity" EXACT []
is_a: GO:0008353 ! RNA polymerase II CTD heptapeptide repeat kinase activity

[Term]
id: GO:0140835
name: RNA polymerase II CTD heptapeptide repeat T4 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4)." [PMID:28248323]
synonym: "RNA polymerase II C-terminal domain T4 kinase activity" EXACT []
is_a: GO:0008353 ! RNA polymerase II CTD heptapeptide repeat kinase activity

[Term]
id: GO:0140836
name: RNA polymerase II CTD heptapeptide repeat S5 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5)." [PMID:28248323]
synonym: "RNA polymerase II C-terminal domain S5 kinase activity" EXACT []
is_a: GO:0008353 ! RNA polymerase II CTD heptapeptide repeat kinase activity

[Term]
id: GO:0140837
name: RNA polymerase II CTD heptapeptide repeat S7 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7)." [PMID:28248323]
synonym: "RNA polymerase II C-terminal domain S7 kinase activity" EXACT []
is_a: GO:0008353 ! RNA polymerase II CTD heptapeptide repeat kinase activity

[Term]
id: GO:0140838
name: RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0)." [PMID:28248323]
is_a: GO:0003755 ! peptidyl-prolyl cis-trans isomerase activity
is_a: GO:0140994 ! RNA polymerase II CTD heptapeptide repeat modifying activity

[Term]
id: GO:0140839
name: RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3)." [PMID:28248323]
synonym: "RNA polymerase II C-terminal domain P3 isomerase activity" EXACT []
is_a: GO:0140838 ! RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity

[Term]
id: GO:0140840
name: RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6)." [PMID:28248323]
synonym: "RNA polymerase II C-terminal domain P6 isomerase activity" EXACT []
is_a: GO:0140838 ! RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity

[Term]
id: GO:0140841
name: RNA polymerase II C-terminal domain O-GlcNAc transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine." [PMID:22605332]
is_a: GO:0097363 ! protein O-acetylglucosaminyltransferase activity

[Term]
id: GO:0140842
name: RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5)." [PMID:22605332]
is_a: GO:0140841 ! RNA polymerase II C-terminal domain O-GlcNAc transferase activity

[Term]
id: GO:0140843
name: RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7)." [PMID:22605332]
is_a: GO:0140841 ! RNA polymerase II C-terminal domain O-GlcNAc transferase activity

[Term]
id: GO:0140844
name: NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue)." [PMID:27530147]
synonym: "NAD+-histone H2B-E2 glutamate ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E2 specific)" EXACT []
is_a: GO:0140807 ! NAD+-protein-glutamate ADP-ribosyltransferase activity

[Term]
id: GO:0140845
name: regulation of promoter clearance from RNA polymerase II promoter
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II." [PMID:28248323]
is_a: GO:2001141 ! regulation of RNA biosynthetic process
relationship: regulates GO:0001111 ! RNA polymerase II promoter clearance

[Term]
id: GO:0140846
name: positive regulation of promoter clearance from RNA polymerase II promoter
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II." [PMID:28248323]
is_a: GO:0140845 ! regulation of promoter clearance from RNA polymerase II promoter
is_a: GO:1902680 ! positive regulation of RNA biosynthetic process
relationship: positively_regulates GO:0001111 ! RNA polymerase II promoter clearance

[Term]
id: GO:0140847
name: negative regulation of promoter clearance from RNA polymerase II promoter
namespace: biological_process
def: "A process that stops, prevents or reduces the transition from the initiation to the elongation phases of transcription by RNA polymerase II." [PMID:28248323]
is_a: GO:0140845 ! regulation of promoter clearance from RNA polymerase II promoter
is_a: GO:1902679 ! negative regulation of RNA biosynthetic process
relationship: negatively_regulates GO:0001111 ! RNA polymerase II promoter clearance

[Term]
id: GO:0140848
name: amino acid:monoatomic cation antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc." [GOC:curators]
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0140849
name: ATP-dependent H2AZ histone chaperone activity
namespace: molecular_function
def: "A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite." [PMID:21241891, PMID:23580526, PMID:30309918]
comment: Drosophila H2AV corresponds to histone H2AZ.
synonym: "ATP-dependent H2A.Z histone chaperone activity" EXACT []
synonym: "H2AZ histone exchange activity" RELATED []
is_a: GO:0140674 ! ATP-dependent histone chaperone activity

[Term]
id: GO:0140850
name: histone H2B C-terminal K residue ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals." [PMID:17363370, PMID:28624371]
synonym: "histone H2B conserved C-terminal lysine ubiquitin ligase activity" EXACT []
synonym: "histone H2B-K120 ubiquitin ligase activity" EXACT []
synonym: "histone H2BK120 ubiquitin ligase activity" EXACT []
synonym: "histone ubiquitin ligase activity (H2B-K120 specific)" EXACT []
is_a: GO:0141054 ! histone H2B ubiquitin ligase activity

[Term]
id: GO:0140851
name: histone H3K14 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue." [PMID:28624371, PMID:31468675, PMID:34010645]
synonym: "histone H3-K14 ubiquitin ligase activity" EXACT []
synonym: "histone ubiquitin ligase activity (H3-K14 specific)" EXACT []
is_a: GO:0141055 ! histone H3 ubiquitin ligase activity

[Term]
id: GO:0140852
name: histone ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of ubiquitin to a histone substrate." [GOC:curators]
is_a: GO:0061630 ! ubiquitin protein ligase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0140853
name: cholesterol-protein transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]." [PMID:8824192, RHEA:59504]
synonym: "cholesterol transferase activity" BROAD []
xref: RHEA:59504
is_a: GO:0016740 ! transferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140854
name: interleukin-19-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-19 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:34052656]
synonym: "IL19-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0140855
name: histone H3S57 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3." [PMID:24820035]
synonym: "histone kinase activity (H3-S57 specific)" EXACT []
synonym: "histone serine kinase activity (H3-S57 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S57 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0140856
name: histone H2AK13 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue." [PMID:22980979, PMID:28624371]
synonym: "histone ubiquitin ligase activity (H2A-K13 specific)" EXACT []
is_a: GO:0141053 ! histone H2A ubiquitin ligase activity

[Term]
id: GO:0140857
name: histone H3T45 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3." [PMID:24820035]
synonym: "histone kinase activity (H3-T45 specific)" EXACT []
synonym: "histone threonine kinase activity (H3-T45 specific)" EXACT []
synonym: "histone-threonine kinase activity (H3-T45 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140996 ! histone H3 kinase activity

[Term]
id: GO:0140858
name: histone H2AK15 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue." [PMID:22980979, PMID:28624371]
synonym: "histone ubiquitin ligase activity (H2A-K15 specific)" EXACT []
is_a: GO:0141053 ! histone H2A ubiquitin ligase activity

[Term]
id: GO:0140859
name: pterocarpan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol." [PMID:7805842, RHEA:35407]
synonym: "2',7-dihydroxy-4'-methoxyisoflavanol dehydratase activity" EXACT [EC:4.2.1.139]
synonym: "2'-hydroxyisoflavanol 4,2'-dehydratase activity" EXACT [EC:4.2.1.139]
synonym: "7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase activity" EXACT [EC:4.2.1.139]
synonym: "medicarpan synthase activity" EXACT [EC:4.2.1.139]
synonym: "medicarpin synthase activity" EXACT [EC:4.2.1.139]
xref: EC:4.2.1.139
xref: RHEA:35407
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0140860
name: (3R)-2'-hydroxyisoflavanone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH." [PMID:7625843, RHEA:56284]
synonym: "vestitone reductase activity" NARROW [EC:1.1.1.348]
xref: RHEA:56284
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0140861
name: DNA repair-dependent chromatin remodeling
namespace: biological_process
def: "A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions." [PMID:15528408, PMID:28053344, PMID:29095668, PMID:35689883]
synonym: "DNA damage-dependent chromatin remodelling" EXACT []
is_a: GO:0006338 ! chromatin remodeling
relationship: part_of GO:0006974 ! DNA damage response

[Term]
id: GO:0140862
name: histone H2AK119 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue." [PMID:22844243, PMID:25470042, PMID:28624371]
synonym: "histone H2A-K119 ubiquitin ligase activity" EXACT []
synonym: "histone ubiquitin ligase activity (H2A-K119 specific)" EXACT []
is_a: GO:0141053 ! histone H2A ubiquitin ligase activity

[Term]
id: GO:0140863
name: histone H2AK127 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-127 residue." [PMID:28624371]
synonym: "histone H2A-K127 ubiquitin ligase activity" EXACT []
synonym: "histone ubiquitin ligase activity (H2A-K127 specific)" EXACT []
is_a: GO:0141053 ! histone H2A ubiquitin ligase activity

[Term]
id: GO:0140864
name: histone H2AK129 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue." [PMID:28624371]
synonym: "histone H2A-K129 ubiquitin ligase activity" EXACT []
synonym: "histone ubiquitin ligase activity (H2A-K129 specific)" EXACT []
is_a: GO:0141053 ! histone H2A ubiquitin ligase activity

[Term]
id: GO:0140865
name: interleukin-22-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-22 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:34755534]
synonym: "IL-22-mediated signaling pathway" EXACT []
synonym: "interleukin-22-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0140866
name: interleukin-20-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by interleukin-20 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:34755534]
synonym: "IL-20-mediated signaling pathway" EXACT []
synonym: "interleukin-20-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0140867
name: NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue)." [PMID:28252050]
synonym: "NAD+-histone H2B-E18 glutamate ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E18 specific)" EXACT []
is_a: GO:0140807 ! NAD+-protein-glutamate ADP-ribosyltransferase activity

[Term]
id: GO:0140868
name: obsolete 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3 H+ + 15-cis-4,4'-diapophytoene + 3 FAD = 4,4'-diapolycopene + 3 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product." [PMID:15933032]
comment: This term was obsoleted because the reaction it represents may not be physiologically relevant.
synonym: "4,4'-diapophytoene desaturase activity" BROAD []
is_obsolete: true
replaced_by: GO:0102223

[Term]
id: GO:0140869
name: miRNA inhibitor activity via base-pairing
namespace: molecular_function
def: "Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs)." [PMID:34454184]
comment: This term is intended for regulatory non-coding RNAs that act by base-pairing with a target microRNA.
synonym: "base-pairing target-directed microRNA suppressor activity" RELATED []
synonym: "base-pairing target-directed miRNA suppressor activity" RELATED []
synonym: "miRNA base-pairing repressor activity" NARROW []
synonym: "miRNA binding involved in posttranscriptional gene silencing" EXACT []
synonym: "miRNA inhibitor activity" BROAD []
synonym: "miRNA sponge" NARROW []
is_a: GO:0035198 ! miRNA binding
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0140870
name: RNA polymerase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of RNA polymerase." [PMID:15300239, PMID:18313387, PMID:31048766]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0140871
name: repressor of RNA polymerase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor." [PMID:28475895, PMID:31048766]
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0140872
name: viridicatumtoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system." [PMID:20534346, PMID:24161266]
synonym: "viridicatumtoxin anabolism" EXACT []
synonym: "viridicatumtoxin biosynthesis" EXACT []
synonym: "viridicatumtoxin formation" EXACT []
synonym: "viridicatumtoxin synthesis" EXACT []
xref: MetaCyc:PWY-7659
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0140873
name: paxilline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels." [PMID:23949005]
synonym: "paxilline anabolism" EXACT []
synonym: "paxilline biosynthesis" EXACT []
synonym: "paxilline formation" EXACT []
synonym: "paxilline synthesis" EXACT []
xref: MetaCyc:PWY-7493
is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0140874
name: paraherquonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture." [PMID:27602587]
synonym: "paraherquonin anabolism" EXACT []
synonym: "paraherquonin biosynthesis" EXACT []
synonym: "paraherquonin formation" EXACT []
synonym: "paraherquonin synthesis" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0140875
name: PR-toxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin." [PMID:24239699, PMID:27921136]
synonym: "PR-toxin anabolism" EXACT []
synonym: "PR-toxin biosynthesis" EXACT []
synonym: "PR-toxin formation" EXACT []
synonym: "PR-toxin synthesis" EXACT []
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process

[Term]
id: GO:0140876
name: andrastin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of andrastin A, a meroterpenoid that exhibits inhibitory activity against ras farnesyltransferase, suggesting that it could have promising antitumor activity." [DOI:10.1016/j.tet.2013.07.029]
synonym: "andrastin A anabolism" EXACT []
synonym: "andrastin A biosynthesis" EXACT []
synonym: "andrastin A formation" EXACT []
synonym: "andrastin A synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0140877
name: mevastatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mevastatin , also known as compactin or ML-236B, and which acts as a potent competitive inhibitor of HMG-CoA reductase." [PMID:12172803, PMID:12242508]
synonym: "mevastatin anabolism" EXACT []
synonym: "mevastatin biosynthesis" EXACT []
synonym: "mevastatin formation" EXACT []
synonym: "mevastatin synthesis" EXACT []
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0140878
name: griseofulvin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections." [PMID:20534346, PMID:23978092]
synonym: "griseofulvin anabolism" EXACT []
synonym: "griseofulvin biosynthesis" EXACT []
synonym: "griseofulvin formation" EXACT []
synonym: "griseofulvin synthesis" EXACT []
xref: MetaCyc:PWY-7653
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:0140879
name: conidiogenone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of conidiogenone , a diterpene known to induce the conidiation." [PMID:30343633]
synonym: "conidiogenone anabolism" EXACT []
synonym: "conidiogenone biosynthesis" EXACT []
synonym: "conidiogenone formation" EXACT []
synonym: "conidiogenone synthesis" EXACT []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0140880
name: terrein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terrein, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities." [PMID:24816227]
synonym: "terrein anabolism" EXACT []
synonym: "terrein biosynthesis" EXACT []
synonym: "terrein formation" EXACT []
synonym: "terrein synthesis" EXACT []
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0140881
name: positive regulation terrein biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of the fungal metabolite terrein." [PMID:24816227, PMID:25852654]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0140880 ! terrein biosynthetic process

[Term]
id: GO:0140882
name: zinc export across plasma membrane
namespace: biological_process
def: "The directed movement of zinc ions from a cell, into the extracellular region." [PMID:17355957]
synonym: "zinc ion export from cell" EXACT []
is_a: GO:0071577 ! zinc ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0140883
name: symbiont-mediated activation of host reticulophagy
namespace: biological_process
def: "A process in which a symbiont initiates, promotes, or enhances the normal execution of host reticulophagy, leading to an increase in the frequency, rate or extent of reticulophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:35239449]
synonym: "activation of host reticulophagy by virus" EXACT []
synonym: "induction by virus of host reticulophagy" NARROW []
synonym: "positive regulation by virus of host reticulophagy" BROAD []
is_a: GO:0039520 ! symbiont-mediated activation of host autophagy

[Term]
id: GO:0140884
name: symbiont-mediated suppression of host type II interferon-mediated signaling pathway
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma." [PMID:28901902]
synonym: "negative regulation by virus of host type II interferon-mediated signaling pathway" EXACT []
synonym: "suppression by virus of host type II IFN-mediated signaling pathway" EXACT []
synonym: "suppression by virus of host type II interferon-mediated signaling pathway" NARROW []
synonym: "suppression by virus of host type II interferon-mediated signalling pathway" EXACT []
is_a: GO:0140886 ! symbiont-mediated suppression of host interferon-mediated signaling pathway

[Term]
id: GO:0140885
name: symbiont-mediated suppression of host type III interferon-mediated signaling pathway
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda." [PMID:32464097]
synonym: "negative regulation by virus of host type III interferon-mediated signaling pathway" EXACT []
synonym: "suppression by virus of host type III IFN-mediated signaling pathway" EXACT []
synonym: "suppression by virus of host type III interferon-mediated signaling pathway" NARROW []
synonym: "suppression by virus of host type III interferon-mediated signalling pathway" EXACT []
is_a: GO:0140886 ! symbiont-mediated suppression of host interferon-mediated signaling pathway

[Term]
id: GO:0140886
name: symbiont-mediated suppression of host interferon-mediated signaling pathway
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism." [PMID:31266861, PMID:33097660, PMID:34305858]
synonym: "inhibition of host interferon signaling pathway by symbiont" RELATED []
synonym: "negative regulation by virus of host interferon-mediated signaling pathway" NARROW []
synonym: "suppression by symbiont of host IFN-mediated signaling pathway" EXACT []
synonym: "suppression by symbiont of host interferon-mediated signalling pathway" EXACT []
synonym: "suppression by virus of host interferon-mediated signaling pathway" NARROW []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0140887
name: positive regulation of nucleosome disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [PMID:34471130, PMID:35308047]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1905269 ! positive regulation of chromatin organization
relationship: positively_regulates GO:0006334 ! nucleosome assembly

[Term]
id: GO:0140888
name: interferon-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by type II interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type II interferon is also known as interferon-gamma." [GOC:add, GOC:dph, GOC:signaling, PMID:32464097]
synonym: "interferon signaling pathway" EXACT []
synonym: "interferon-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0140889
name: DNA replication-dependent chromatin disassembly
namespace: biological_process
def: "The disruption of nucleosomes during DNA replication to allow the replication machinery to access the DNA." [PMID:34471130, PMID:35308047]
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0140890
name: H1 histone chaperone activity
namespace: molecular_function
def: "A histone chaperone that carries a H1 histone." [PMID:12509435]
synonym: "H1 histone carrier activity" EXACT []
is_a: GO:0140713 ! histone chaperone activity

[Term]
id: GO:0140891
name: tRNA-derived regulatory ncRNA processing
namespace: biological_process
def: "A process leading to the generation of a functional small regulatory non-coding RNA derived from a tRNA." [PMID:29120263]
synonym: "tRNA-derived small RNA processing" RELATED []
is_a: GO:0070918 ! regulatory ncRNA processing

[Term]
id: GO:0140892
name: sodium,bicarbonate:chloride antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in)." [PMID:18577713, PMID:20389022, PMID:8189393]
synonym: "sodium,hydrogencarbonate:chloride antiporter activity" EXACT []
synonym: "sodium-dependent chloride/bicarbonate exchanger activity" EXACT []
xref: TC:2.A.31.2.4
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0140828 ! metal cation:monoatomic cation antiporter activity
is_a: GO:0140900 ! chloride:bicarbonate antiporter activity

[Term]
id: GO:0140893
name: neutral amino acid, sodium:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + amino acid(out) + Na+(out) = H+(out) + amino acid(in) + Na+(in)." [PMID:11698233, PMID:34704597]
synonym: "amino acid-coupled Na+/H+ exchanger activity" EXACT []
xref: TC:2.A.18.6.8
is_a: GO:0015385 ! sodium:proton antiporter activity

[Term]
id: GO:0140894
name: endolysosomal toll-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to an endolysosomal pattern recognition receptor (PRR) of the toll-like family. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [PMID:29679565]
synonym: "endolysosomal pattern recognition receptor signaling pathway" EXACT []
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0140895
name: cell surface toll-like receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR) of the toll-like family." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "cell surface TLR signaling pathway" EXACT []
is_a: GO:0002752 ! cell surface pattern recognition receptor signaling pathway

[Term]
id: GO:0140896
name: cGAS/STING signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING." [PMID:27648547, PMID:34261127, PMID:34261128]
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0140897
name: mechanoreceptor activity
namespace: molecular_function
def: "Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [PMID:23907979, PMID:34666001]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0140898
name: CENP-A eviction from euchromatin
namespace: biological_process
def: "A chromatin remodeling process in which CENP-A is removed from euchromatin regions to prevent neocentromere formation." [PMID:27666591]
is_a: GO:0006338 ! chromatin remodeling

[Term]
id: GO:0140899
name: plastid gene expression
namespace: biological_process
def: "The process in which a plastid gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:28377785]
is_a: GO:0010467 ! gene expression

[Term]
id: GO:0140900
name: chloride:bicarbonate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in)." [PMID:10428871, PMID:16606687, RHEA:72203]
synonym: "bicarbonate:chloride antiporter activity" EXACT []
synonym: "chloride:hydrogencarbonate antiporter activity" EXACT []
xref: RHEA:72203
xref: TC:2.A.53.2.18
is_a: GO:0005452 ! solute:inorganic anion antiporter activity
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0140829 ! bicarbonate:monoatomic anion antiporter activity

[Term]
id: GO:0140901
name: L-asparagine:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in)." [PMID:21511949, PMID:28416685]
synonym: "asparagine:sodium symporter activity" EXACT []
synonym: "sodium:asparagine symporter activity" EXACT []
synonym: "sodium:L-asparagine symporter activity" EXACT []
xref: RHEA:71383
xref: TC:2.A.18.6.13
is_a: GO:0005295 ! neutral L-amino acid:sodium symporter activity
is_a: GO:0015182 ! L-asparagine transmembrane transporter activity
is_a: GO:0015655 ! alanine:sodium symporter activity

[Term]
id: GO:0140902
name: L-glutamine:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in)." [PMID:28416685]
synonym: "glutamine:sodium symporter activity" EXACT []
synonym: "sodium:glutamine symporter activity" EXACT []
synonym: "sodium:L-glutamine symporter activity" EXACT []
xref: TC:2.A.18.6.13
is_a: GO:0005295 ! neutral L-amino acid:sodium symporter activity
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity
is_a: GO:0015655 ! alanine:sodium symporter activity

[Term]
id: GO:0140903
name: histone H3R26 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3." [PMID:17882261]
synonym: "histone H3R26 arginine methyltransferase activity" EXACT [GOC:mah]
synonym: "histone methylase activity (H3-R26 specific)" EXACT []
synonym: "histone methyltransferase activity (H3-R26 specific)" EXACT []
synonym: "histone-arginine N-methyltransferase activity (H3-R26 specific)" EXACT []
synonym: "histone-H3R26 methyltransferase activity" EXACT []
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0140938 ! histone H3 methyltransferase activity

[Term]
id: GO:0140904
name: cytoophidium organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a cytoophidium. Cytoophidia are mesoscale, intracellular, filamentous structures that contain metabolic enzymes." [PMID:25223282, PMID:27362644]
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0140905
name: haloperoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CH + a halogen + H2O2 = R-C-halogen + H2O." [PMID:28466644, PMID:34368824]
is_a: GO:0004601 ! peroxidase activity
is_a: GO:0140906 ! halogenase activity

[Term]
id: GO:0140906
name: halogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O." [PMID:28466644, PMID:34368824]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0140907
name: flavin-dependent halogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O." [PMID:28466644, PMID:34368824]
is_a: GO:0140906 ! halogenase activity

[Term]
id: GO:0140908
name: histone H3K122 acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122)." [PMID:23415232]
synonym: "histone acetylase activity (H3-K122 specific)" EXACT []
synonym: "histone acetyltransferase activity (H3-K122 specific)" EXACT []
synonym: "histone H3-K122 acetyltransferase activity" EXACT []
synonym: "histone lysine N-acetyltransferase activity (H3-K122 specific)" EXACT []
is_a: GO:0010484 ! histone H3 acetyltransferase activity

[Term]
id: GO:0140909
name: kinetoplast DNA replication
namespace: biological_process
def: "The process of doubling of the number of maxicircles and minicircles and distribution of the progeny into two daughter networks, which are identical to the parent kinetoplast DNA network." [GOC:ach, PMID:12455998, PMID:15967722, PMID:17462016, PMID:8045928, PMID:8561456]
synonym: "kDNA replication" EXACT []
synonym: "kinetoplast DNA synthesis" EXACT []
synonym: "replication of kinetoplast DNA" EXACT []
is_a: GO:0006264 ! mitochondrial DNA replication

[Term]
id: GO:0140910
name: iRhom2/ADAM17 sheddase complex
namespace: cellular_component
def: "A complex consisting of ADAM17 in complex with regulatory iRhoms and FERM domain containing proteins." [PMID:29897336]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0140911
name: pore-forming activity
namespace: molecular_function
alt_id: GO:0034290
alt_id: GO:0034291
alt_id: GO:0034292
def: "An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death." [PMID:1406491, PMID:25157079, PMID:34387717]
synonym: "canonical holin activity" NARROW []
synonym: "holin activity" NARROW []
synonym: "pinholin activity" NARROW []
synonym: "pore forming activity" EXACT []
xref: TC:1.C
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140912
name: membrane destabilizing activity
namespace: molecular_function
def: "Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release." [PMID:34496967]
synonym: "antimicrobial peptide" BROAD []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0140913
name: viral release via disruption of host peptidoglycan cell wall
namespace: biological_process
def: "The dissemination of mature viral particles from a host cell, caused by a virus hydrolyzing the peptidoglycan cell wall of the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [PMID:24585055, PMID:26085488, PMID:29495305]
is_a: GO:0044659 ! viral release from host cell by cytolysis

[Term]
id: GO:0140914
name: zinc ion import into secretory vesicle
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a secretory vesicle." [PMID:19496757]
is_a: GO:0062111 ! zinc ion import into organelle

[Term]
id: GO:0140915
name: zinc ion import into zymogen granule
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a zymogen granule." [PMID:20133611]
is_a: GO:0140914 ! zinc ion import into secretory vesicle

[Term]
id: GO:0140916
name: zinc ion import into lysosome
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a lysosome." [PMID:25808614]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0062111 ! zinc ion import into organelle

[Term]
id: GO:0140917
name: zinc ion import into mitochondrion
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a mitochondrion." [PMID:21289295]
is_a: GO:0062111 ! zinc ion import into organelle
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:0140918
name: centrosomal core
namespace: cellular_component
def: "The core region of the centrosome, a layered structure containing proteins, surrounded by the centrosomal corona. The core duplicates once per cell cycle at the G2/M transition when two outer layers form the mitotic spindle poles." [PMID:28104305, PMID:30413081]
synonym: "centrosome core" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0140919
name: thermomorphogenesis
namespace: biological_process
def: "The suite of morphological and architectural changes in an organism induced by high ambient temperatures, below the heat-stress range." [PMID:27250752]
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0140920
name: regulation of thermomorphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thermomorphogenesis." [PMID:27250752]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0140919 ! thermomorphogenesis

[Term]
id: GO:0140921
name: negative regulation of thermomorphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thermomorphogenesis." [PMID:27250752]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0140920 ! regulation of thermomorphogenesis
relationship: negatively_regulates GO:0140919 ! thermomorphogenesis

[Term]
id: GO:0140922
name: positive regulation of thermomorphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of thermomorphogenesis." [PMID:27250752]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0140920 ! regulation of thermomorphogenesis
relationship: positively_regulates GO:0140919 ! thermomorphogenesis

[Term]
id: GO:0140923
name: magnetosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a magnetosome. Magnetosomes are specialized organelles for magnetic navigation that comprise membrane-enveloped, nano-sized crystals of a magnetic iron mineral; they are formed by a diverse group of magnetotactic bacteria (MTB)." [PMID:19575557, PMID:34723168]
synonym: "magnetosome formation" EXACT []
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0140924
name: L-kynurenine transmembrane transport
namespace: biological_process
def: "The directed movement of L-kynurenine across a membrane." [PMID:35245456]
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0140925
name: L-phenylalanine import across plasma membrane
namespace: biological_process
def: "The directed movement of L-phenylalanine from outside of a cell, across the plasma membrane and into the cytosol." [PMID:11069779]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015801 ! aromatic amino acid transport
is_a: GO:0015823 ! phenylalanine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0140926
name: L-kynurenine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-kynurenine from one side of a membrane to the other." [PMID:35245456]
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0140927
name: cyclic-di-GMP transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cyclic-di-GMP from one side of a membrane to the other." [PMID:34965418]
is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0140928
name: inhibition of non-skeletal tissue mineralization
namespace: biological_process
def: "A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue." [PMID:21490328, PMID:30030150]
synonym: "inhibition of ectopic tissue mineralization" NARROW []
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0140929
name: mannose:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in)." [PMID:22212718, PMID:23451068, PMID:24573086]
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0140930
name: fructose:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-fructose(out) + Na+(out) = D-fructose(in) + Na+(in)." [PMID:22212718, PMID:23451068]
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0140931
name: neutral L-amino acid:sodium:chloride symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) + Cl-(out) = neutral L-amino acid(in) + Na+(in)+ Cl-(in)." [PMID:19478081]
synonym: "neutral amino acid:sodium:chloride symporter activity" EXACT []
is_a: GO:0005283 ! amino acid:sodium symporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity

[Term]
id: GO:0140932
name: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate." [PMID:24742626, PMID:32723815]
synonym: "m(7)GpppN m(7)GMP phosphohydrolase activity" EXACT [EC:3.6.1.59]
synonym: "m(7)GpppX diphosphatase activity" EXACT [EC:3.6.1.59]
synonym: "m(7)GpppX pyrophosphatase activity" EXACT [EC:3.6.1.59]
xref: EC:3.6.1.59
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0140933
name: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+." [PMID:18820299, PMID:29483298]
synonym: "m(7)GpppN-mRNA hydrolase activity" EXACT []
xref: EC:3.6.1.62
xref: RHEA:67484
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0140934
name: histone deubiquitinase activity
namespace: molecular_function
def: "A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated." [PMID:18206972, PMID:18226187]
synonym: "histone deubiquitination" RELATED []
is_a: GO:0101005 ! deubiquitinase activity
is_a: GO:0140993 ! histone modifying activity

[Term]
id: GO:0140935
name: histone H2B conserved C-terminal lysine deubiquitinase activity
namespace: molecular_function
def: "A histone deubiquitinase that cleaves ubiquitin from the conserved C-terminal lysine residue of a histone H2B protein to which it is conjugated. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals." [PMID:15657442]
synonym: "histone conserved C-terminal lysine deubiquitination" RELATED []
is_a: GO:0140936 ! histone H2B deubiquitinase activity

[Term]
id: GO:0140936
name: histone H2B deubiquitinase activity
namespace: molecular_function
def: "A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated." [PMID:18206972, PMID:29352077]
synonym: "histone H2B deubiquitination" RELATED []
is_a: GO:0140934 ! histone deubiquitinase activity

[Term]
id: GO:0140937
name: histone H4K12 deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein." [GOC:vw, PMID:15293224]
synonym: "histone deacetylase activity (H4-K12 specific)" EXACT []
synonym: "histone H4-K12 deacetylase activity" EXACT []
synonym: "histone H4-K12 deacetylation" RELATED []
synonym: "histone H4K12 deacetylase activity" BROAD []
synonym: "histone H4K12 deacetylation" RELATED []
is_a: GO:0141051 ! histone H4K deacetylase activity

[Term]
id: GO:0140938
name: histone H3 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue." [PMID:28450737]
synonym: "histone H3 methylase activity" EXACT []
synonym: "histone H3 methylation" RELATED []
xref: Reactome:R-HSA-3788745 "EHMT1:EHMT2 methylates IL8 promoter"
xref: Reactome:R-HSA-3788748 "EHMT1:EHMT2 methylates IL6 promoter"
xref: Reactome:R-HSA-4827382 "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)"
xref: Reactome:R-HSA-4827383 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)"
xref: Reactome:R-HSA-5159245 "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)"
xref: Reactome:R-HSA-5205799 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)"
xref: Reactome:R-HSA-5244692 "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)"
xref: Reactome:R-HSA-5634729 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)"
xref: Reactome:R-HSA-5634750 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)"
xref: Reactome:R-HSA-5634802 "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)"
xref: Reactome:R-HSA-5637686 "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)"
xref: Reactome:R-HSA-5638141 "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)"
xref: Reactome:R-HSA-5638157 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36)"
xref: Reactome:R-HSA-5638332 "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)"
xref: Reactome:R-HSA-5638333 "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)"
xref: Reactome:R-HSA-5649764 "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)"
xref: Reactome:R-HSA-5649799 "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)"
xref: Reactome:R-HSA-5649800 "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)"
xref: Reactome:R-HSA-5649801 "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)"
xref: Reactome:R-HSA-5649802 "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)"
xref: Reactome:R-HSA-5661117 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3"
xref: Reactome:R-HSA-8936584 "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter"
xref: Reactome:R-HSA-8936608 "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter"
xref: Reactome:R-HSA-8937022 "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter"
xref: Reactome:R-HSA-8937113 "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter"
xref: Reactome:R-HSA-9842833 "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes"
xref: Reactome:R-HSA-9844006 "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)"
xref: Reactome:R-HSA-9844057 "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome"
is_a: GO:0042054 ! histone methyltransferase activity

[Term]
id: GO:0140939
name: histone H4 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue." [PMID:28450737]
synonym: "histone H4 methylase activity" EXACT []
synonym: "histone H4 methylation" EXACT []
xref: Reactome:R-HSA-5423038 "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)"
xref: Reactome:R-HSA-5651654 "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)"
xref: Reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)"
is_a: GO:0042054 ! histone methyltransferase activity

[Term]
id: GO:0140940
name: histone H2A methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue." [PMID:28450737]
synonym: "histone H2A methylase activity" EXACT []
synonym: "histone H2A methylation" RELATED []
is_a: GO:0042054 ! histone methyltransferase activity

[Term]
id: GO:0140941
name: histone H4K20me methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethlyated lysine residue at position 20 of histone H4, producing H4K20me2." [RHEA:60348]
synonym: "histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific)" EXACT []
synonym: "histone H4-K20 dimethylation" BROAD []
synonym: "histone H4K20 dimethylation" BROAD []
synonym: "histone H4K20me methylase activity" EXACT []
xref: EC:2.1.1.362
xref: RHEA:60348
is_a: GO:0042799 ! histone H4K20 methyltransferase activity

[Term]
id: GO:0140942
name: histone H3K9 dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2." [RHEA:64444]
synonym: "histone H3-K9 dimethylation" BROAD []
synonym: "histone H3K9 dimethylase activity" EXACT []
synonym: "histone H3K9 dimethylation" BROAD []
synonym: "histone H3K9 mono/dimethylase activity" EXACT []
synonym: "histone lysine N-dimethyltransferase activity (H3-K9 specific)" EXACT []
xref: EC:2.1.1.368
xref: RHEA:64444
is_a: GO:0046974 ! histone H3K9 methyltransferase activity

[Term]
id: GO:0140943
name: histone H4K20 trimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3." [RHEA:64456]
synonym: "histone H4K20 trimethylase activity" EXACT []
synonym: "histone H4K20 trimethylation" EXACT []
synonym: "histone lysine N-trimethyltransferase activity (H4-K20 specific)" EXACT []
xref: EC:2.1.1.372
xref: RHEA:64456
is_a: GO:0042799 ! histone H4K20 methyltransferase activity

[Term]
id: GO:0140944
name: histone H4K20 monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me." [RHEA:60344]
synonym: "histone H4-K20 methylation" BROAD []
synonym: "histone H4K20 methylase activity" BROAD []
synonym: "histone H4K20 methylation" BROAD []
synonym: "histone H4K20 monomethylation" EXACT []
synonym: "histone lysine N-monomethyltransferase activity (H4-K20 specific)" EXACT []
xref: EC:2.1.1.361
xref: RHEA:60344
is_a: GO:0042799 ! histone H4K20 methyltransferase activity

[Term]
id: GO:0140945
name: histone H3K4 monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me." [RHEA:60264]
synonym: "histone H3K4 monomethylase activity" EXACT []
synonym: "histone H4-K4 methylation" BROAD []
synonym: "histone H4K4 methylation" BROAD []
synonym: "histone lysine N-monomethyltransferase activity (H3-K4 specific)" EXACT []
xref: EC:2.1.1.364
xref: RHEA:60264
is_a: GO:0042800 ! histone H3K4 methyltransferase activity

[Term]
id: GO:0140946
name: histone H3K4 dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2." [RHEA:64448]
synonym: "histone H3-K4 dimethylation" BROAD []
synonym: "histone H3K4 dimethylase activity" EXACT []
synonym: "histone H3K4 dimethylation" BROAD []
synonym: "histone lysine N-dimethyltransferase activity (H3-K4 specific)" EXACT []
xref: EC:2.1.1.370
xref: RHEA:64448
is_a: GO:0042800 ! histone H3K4 methyltransferase activity

[Term]
id: GO:0140947
name: histone H3K9me2 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3." [RHEA:60280]
synonym: "histone dimethyl-lysine(H3K9) N-methyltransferase activity (H3-K9 specific)" EXACT []
synonym: "histone H3-K9 trimethylation" BROAD []
synonym: "histone H3K9 trimethylation" BROAD []
synonym: "histone H3K9me2 methylase activity" EXACT []
xref: EC:2.1.1.366
xref: RHEA:60280
is_a: GO:0046974 ! histone H3K9 methyltransferase activity

[Term]
id: GO:0140948
name: histone H3K9 monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me." [RHEA:60288]
synonym: "histone H3-K9 methylation" BROAD []
synonym: "histone H3K9 methylation" BROAD []
synonym: "histone H3K9 monomethylase activity" EXACT []
synonym: "histone lysine N-monomethyltransferase activity (H3-K9 specific)" EXACT []
xref: EC:2.1.1.367
xref: RHEA:60288
is_a: GO:0046974 ! histone H3K9 methyltransferase activity

[Term]
id: GO:0140949
name: histone H3K9 trimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3." [RHEA:60276]
synonym: "histone H3-K9 trimethylation" BROAD []
synonym: "histone H3K9 mono/di/trimethylase activity" EXACT []
synonym: "histone H3K9 trimethylase activity" EXACT []
synonym: "histone H3K9 trimethylation" BROAD []
synonym: "histone lysine N-trimethyltransferase activity (H3-K9 specific)" EXACT []
xref: EC:2.1.1.355
xref: RHEA:60276
is_a: GO:0046974 ! histone H3K9 methyltransferase activity

[Term]
id: GO:0140950
name: histone H2A deubiquitinase activity
namespace: molecular_function
def: "A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated." [PMID:18226187, PMID:20436459]
synonym: "histone H2A deubiquitination" RELATED []
is_a: GO:0140934 ! histone deubiquitinase activity

[Term]
id: GO:0140951
name: histone H3K27 trimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3." [RHEA:60292]
synonym: "histone H3-K27 trimethylase activity" EXACT []
synonym: "histone H3-K27 trimethylation" BROAD []
synonym: "histone H3K27 mono/di/trimethylase activity" EXACT []
synonym: "histone H3K27 trimethylase activity" EXACT []
synonym: "histone H3K27 trimethylation" BROAD []
synonym: "histone lysine N-trimethyltransferase activity (H3-K27 specific)" EXACT []
xref: RHEA:60292
is_a: GO:0046976 ! histone H3K27 methyltransferase activity

[Term]
id: GO:0140952
name: histone H3K27 dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2." [RHEA:64452]
synonym: "histone H3-K27 dimethylase activity" EXACT []
synonym: "histone H3-K27 dimethylation" BROAD []
synonym: "histone H3K27 dimethylase activity" EXACT []
synonym: "histone H3K27 dimethylation" BROAD []
synonym: "histone H3K27 mono/dimethylase activity" EXACT []
synonym: "histone lysine N-dimethyltransferase activity (H3-K27 specific)" EXACT []
xref: EC:2.1.1.371
xref: RHEA:64452
is_a: GO:0046976 ! histone H3K27 methyltransferase activity

[Term]
id: GO:0140953
name: histone H3K27 monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me." [RHEA:60296]
synonym: "histone H3-K27 methylation" BROAD []
synonym: "histone H3-K27 monomethylase activity" EXACT []
synonym: "histone H3K27 methylation" BROAD []
synonym: "histone H3K27 monomethylase activity" EXACT []
synonym: "histone lysine N-monomethyltransferase activity (H3-K27 specific)" EXACT []
xref: EC:2.1.1.369
xref: RHEA:60296
is_a: GO:0046976 ! histone H3K27 methyltransferase activity

[Term]
id: GO:0140954
name: histone H3K36 dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2." [RHEA:60308]
synonym: "histone H3-K36 dimethylation" BROAD []
synonym: "histone H3K36 dimethylase activity" EXACT []
synonym: "histone H3K36 dimethylation" BROAD []
synonym: "histone H3K36 mono/dimethylase activity" EXACT []
synonym: "histone lysine N-dimethyltransferase activity (H3-K36 specific)" EXACT []
xref: EC:2.1.1.357
xref: RHEA:60308
is_a: GO:0046975 ! histone H3K36 methyltransferase activity

[Term]
id: GO:0140955
name: histone H3K36 trimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3." [RHEA:60324]
synonym: "histone H3-K36 trimethylation" BROAD []
synonym: "histone H3K36 mono/di/trimethylase activity" EXACT []
synonym: "histone H3K36 trimethylase activity" EXACT []
synonym: "histone H3K36 trimethylation" BROAD []
synonym: "histone lysine N-trimethyltransferase activity (H3-K36 specific)" EXACT []
xref: EC:2.1.1.359
xref: RHEA:60324
is_a: GO:0046975 ! histone H3K36 methyltransferase activity

[Term]
id: GO:0140956
name: histone H3K79 trimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3." [PMID:15371351, RHEA:60328]
synonym: "histone H3-K79 trimethylation" BROAD []
synonym: "histone H3K79 trimethylase activity" EXACT []
synonym: "histone H3K79 trimethylation" BROAD []
synonym: "histone lysine N-trimethyltransferase activity (H3-K79 specific)" EXACT []
synonym: "histone trimethylase activity (H3-K79 specific)" EXACT [GOC:mah]
synonym: "histone trimethyltransferase activity (H3-K79 specific)" EXACT []
synonym: "histone-H3K79 trimethyltransferase activity" EXACT []
xref: EC:2.1.1.360
xref: RHEA:60328
is_a: GO:0031151 ! histone H3K79 methyltransferase activity

[Term]
id: GO:0140958
name: target-directed miRNA degradation
namespace: biological_process
def: "The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases." [PMID:33184237, PMID:36150386]
synonym: "target-directed microRNA degradation" EXACT []
synonym: "TDMD" EXACT []
is_a: GO:0010587 ! miRNA catabolic process
is_a: GO:0016441 ! post-transcriptional gene silencing
is_a: GO:0060965 ! negative regulation of miRNA-mediated gene silencing

[Term]
id: GO:0140959
name: obsolete base-pairing target-directed miRNA suppressor activity
namespace: molecular_function
def: "OBSOLETE. An inhibitor activity that acts by base-pairing with a miRNA, exposing it to nuclease-mediated degradation." [PMID:33184237, PMID:36150386]
comment: This term was obsoleted because it represents the same function as miRNA inhibitor activity, GO:0140869.
synonym: "base-pairing target-directed microRNA suppressor activity" EXACT []
is_obsolete: true
replaced_by: GO:0140869

[Term]
id: GO:0140961
name: cellular detoxification of metal ion
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion." [PMID:26729300, PMID:33046888, PMID:34442707]
synonym: "cellular detoxification of metal cation" EXACT []
is_a: GO:0061687 ! detoxification of inorganic compound
is_a: GO:1990748 ! cellular detoxification

[Term]
id: GO:0140962
name: multicellular organismal-level chemical homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:curators]
synonym: "multicellular organism level chemical homeostasis" EXACT []
synonym: "organismal level chemical homeostasis" EXACT []
is_a: GO:0048871 ! multicellular organismal-level homeostasis
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0140963
name: obsolete multicellular organismal-level auxin homeostasis
namespace: biological_process
def: "OBSOLETE. A chemical homeostatic process involved in the maintenance of a steady state level of auxin within extracellular body fluids, such as the xylem or phloem of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:curators]
comment: This term was obsoleted because it was created by error.
synonym: "auxin homeostasis" BROAD []
synonym: "multicellular organismal auxin homeostasis" EXACT []
is_obsolete: true
consider: GO:0060918

[Term]
id: GO:0140964
name: intracellular auxin homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of auxin within a cell." [PMID:19506555, PMID:22314799]
synonym: "auxin homeostasis" BROAD []
synonym: "cellular auxin homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0140965
name: secondary piRNA processing
namespace: biological_process
def: "A process leading to the generation of a functional secondary piRNA, involving a self-perpetuating piRNA loop, often called the ping-pong cycle, in which piRNAs are amplified by pairing with complementary transcripts (for example the transposable element mRNA target). In Drosophila, the processing involves the piwi proteins aubergine and Argonaute 3 and in mice, the piwi proteins Piwil2 and Piwil4." [PMID:29281264, PMID:32895365]
synonym: "ping-pong amplification" RELATED []
synonym: "ping-pong derived piRNA" EXACT []
synonym: "secondary piRNA biogenesis" EXACT []
synonym: "secondary PIWI-associated RNA processing" EXACT []
is_a: GO:0034587 ! piRNA processing

[Term]
id: GO:0140966
name: piRNA-mediated heterochromatin formation
namespace: biological_process
def: "The formation of heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a Piwi-associated RNA (piRNA)." [PMID:23329111]
synonym: "piRNA-directed heterochromatin formation" EXACT []
synonym: "piwiRNA-directed heterochromatin formation" EXACT []
is_a: GO:0031048 ! regulatory ncRNA-mediated heterochromatin formation

[Term]
id: GO:0140967
name: manganese import into cell
namespace: biological_process
def: "The directed movement of mangnanese ions from outside of a cell into a cell." [PMID:22773749]
synonym: "manganese influx" BROAD []
is_a: GO:0071421 ! manganese ion transmembrane transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:0140968
name: polyspecific organic cation:proton antiporter activity
namespace: molecular_function
def: "Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics." [PMID:17047166, PMID:17509534]
synonym: "proton:polyspecific organic cation antiporter activity" RELATED []
xref: TC:2.A.66.1.20
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0140969
name: determination of lung left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the lungs with respect to the left and right halves of the organism." [GOC:BHFL, GOC:rl, PMID:19944405, PMID:20007846, PMID:21131974]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0140970
name: AIM2 inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the AIM2 inflammasome complex." [PMID:33467177]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0140971
name: regulation of AIM2 inflammasome complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of AIM2 inflammasome complex assembly." [PMID:33467177]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: part_of GO:0141085 ! regulation of inflammasome-mediated signaling pathway
relationship: regulates GO:0140970 ! AIM2 inflammasome complex assembly

[Term]
id: GO:0140972
name: negative regulation of AIM2 inflammasome complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AIM2 inflammasome complex assembly." [PMID:33467177]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0140971 ! regulation of AIM2 inflammasome complex assembly
relationship: negatively_regulates GO:0140970 ! AIM2 inflammasome complex assembly
relationship: part_of GO:0141086 ! negative regulation of inflammasome-mediated signaling pathway

[Term]
id: GO:0140973
name: positive regulation of AIM2 inflammasome complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AIM2 inflammasome complex assembly." [PMID:33467177]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0140971 ! regulation of AIM2 inflammasome complex assembly
relationship: part_of GO:0141087 ! positive regulation of inflammasome-mediated signaling pathway
relationship: positively_regulates GO:0140970 ! AIM2 inflammasome complex assembly

[Term]
id: GO:0140974
name: cellular detoxification of sulfide
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of a sulfide. These may include chemical modification or transport of sulfide away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [PMID:20077566, PMID:25747485]
is_a: GO:1990748 ! cellular detoxification

[Term]
id: GO:0140975
name: disruption of cellular anatomical structure in another organism
namespace: biological_process
def: "The disruption of a cellular component of another organism, leading to damage or temporary subversion of that structure. In some cases this can cause malfunctioning of the cells and death of the target organism." [GOC:pg]
synonym: "disruption of cellular component of another organism" BROAD []
is_a: GO:0141060 ! disruption of anatomical structure in another organism

[Term]
id: GO:0140976
name: host defense response against symbiont-mediated perturbation of plasma membrane integrity
namespace: biological_process
def: "The cellular processes and signaling pathways by which a cell responds to disruption of the integrity of its plasma membrane by another organism. Some toxins produced by other organisms can form pores in membranes, or affect the membrane permeability." [PMID:17234446, PMID:21518219]
synonym: "defense response against disruption of plasma membrane integrity" EXACT []
synonym: "defense response against perturbation of plasma membrane integrity" RELATED []
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0140977
name: cellular detoxification of acetone
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of acetone. These may include chemical modification, for example to methylglyoxal." [PMID:22314896, PMID:26958851]
is_a: GO:1990748 ! cellular detoxification

[Term]
id: GO:0140978
name: mitochondrial large ribosomal subunit binding
namespace: molecular_function
def: "Binding to a mitochondrial large ribosomal subunit." [PMID:28892042]
synonym: "mitochondrial ribosomal large subunit binding" EXACT []
is_a: GO:0043023 ! ribosomal large subunit binding
is_a: GO:0097177 ! mitochondrial ribosome binding

[Term]
id: GO:0140979
name: intracellular nucleotide homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of nucleotides within a cell." [PMID:23416111, PMID:34880500]
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0140980
name: intracellular nucleoside homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of nucleosides within a cell." [PMID:23416111, PMID:34880500]
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0140981
name: medium-chain fatty acid omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:75279]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
xref: MetaCyc:RXN-19719
xref: RHEA:75279
is_a: GO:0120250 ! fatty acid omega-hydroxylase activity

[Term]
id: GO:0140982
name: detoxification of aluminum ion
namespace: biological_process
def: "Any process that reduce or remove the toxicity of aluminum ions. These can include transport of the aluminum away from sensitive areas, sequesteration, or chemical modification to an inert form." [PMID:10845450, PMID:23888867, PMID:9576769]
synonym: "aluminum ion homeostasis" RELATED []
is_a: GO:0061687 ! detoxification of inorganic compound

[Term]
id: GO:0140983
name: calcium:manganese antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in)." [PMID:30755481]
synonym: "manganese:calcium antiporter activity" EXACT []
xref: RHEA:73059
is_a: GO:0005384 ! manganese ion transmembrane transporter activity
is_a: GO:0015368 ! calcium:monoatomic cation antiporter activity

[Term]
id: GO:0140984
name: histone H4K12 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein." [PMID:12086618]
comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies.
synonym: "histone H4 lysine 12-specific methyltransferase activity" EXACT []
synonym: "histone H4K12 methylase activity" BROAD []
synonym: "histone H4K12 methylation" EXACT []
synonym: "histone lysine N-methyltransferase activity (H4-K12 specific)" EXACT []
synonym: "histone methylase activity (H4-K12 specific)" EXACT []
synonym: "histone methyltransferase activity (H4-K12 specific)" EXACT []
synonym: "histone-H4K12 methyltransferase activity" EXACT []
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0140939 ! histone H4 methyltransferase activity

[Term]
id: GO:0140985
name: G protein-coupled chemorepellent receptor activity
namespace: molecular_function
def: "Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [PMID:30462573]
synonym: "G protein chemorepellent receptor activity" EXACT []
synonym: "G-protein chemorepellent receptor activity" EXACT []
synonym: "G-protein coupled chemorepellent receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0140986
name: G protein-coupled chemorepellent receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a chemorepellent binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization." [PMID:30462573]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0140987
name: ATP:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + phosphate(in) = ATP(in) + phosphate(out)." [PMID:15123600]
synonym: "ATP:inorganic phosphate antiporter activity" EXACT []
synonym: "inorganic phosphate:ATP antiporter activity" EXACT []
xref: RHEA:65840
is_a: GO:0005347 ! ATP transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:phosphate antiporter activity

[Term]
id: GO:0140988
name: ADP:phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + phosphate(in) = ADP(in) + phosphate(out)." [PMID:15123600]
synonym: "ADP:inorganic phosphate antiporter activity" EXACT []
synonym: "inorganic phosphate:ADP antiporter activity" EXACT []
xref: RHEA:65844
is_a: GO:0015217 ! ADP transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:phosphate antiporter activity

[Term]
id: GO:0140989
name: 7-deoxyloganate 7-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganate + oxidized [NADPH-hemoprotein reductase]." [PMID:24710322, RHEA:57576]
xref: RHEA:57576
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0140990
name: primary piRNA processing
namespace: biological_process
def: "The process involved in converting precursor piRNAs into non-overlapping, contiguous primary piRNAs (approximately 24-30-nt piRNAs with a preference for a 5' uridine (U) via the endonucleolytic activity of cytosolic PIWI. This may include pre-piRNA maturation of 3' ends by trimming and 2'-O-methylation." [PMID:22907665, PMID:26166577, PMID:34469728]
is_a: GO:0034587 ! piRNA processing

[Term]
id: GO:0140991
name: piRNA-mediated gene silencing by mRNA destabilization
namespace: biological_process
def: "A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping." [PMID:29281264, PMID:33419460]
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing
is_a: GO:0061157 ! mRNA destabilization

[Term]
id: GO:0140993
name: histone modifying activity
namespace: molecular_function
def: "A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression." [GOC:pg]
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140994
name: RNA polymerase II CTD heptapeptide repeat modifying activity
namespace: molecular_function
def: "A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity." [GOC:pg]
synonym: "RNA polymerase II CTD repeat modifying activity" EXACT []
synonym: "RNA polymerase II large subunit CTD heptapeptide repeat modifying activity" EXACT []
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0140995
name: histone H2A kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone H2A." [PMID:25303536]
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0140996
name: histone H3 kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone H3." [PMID:25303536]
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0140997
name: histone H4 kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone H4." [PMID:25303536]
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0140998
name: histone H2B kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone H2B." [PMID:25303536]
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0140999
name: histone H3K4 trimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3." [PMID:18375658, RHEA:60260]
synonym: "histone H3-K4 trimethylation" BROAD []
synonym: "histone H3K4 trimethylase activity" EXACT []
synonym: "histone H3K4 trimethylation" BROAD []
synonym: "histone lysine N-trimethyltransferase activity (H3-K4 specific)" EXACT []
xref: EC:2.1.1.354
xref: RHEA:60260
is_a: GO:0042800 ! histone H3K4 methyltransferase activity

[Term]
id: GO:0141000
name: histone H4K91 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin molecule to histone 4 at the lysine-91 residue." [PMID:19818714]
synonym: "histone H4-K91 ubiquitin ligase activity" EXACT []
synonym: "histone ubiquitin ligase activity (H4-K91 specific)" EXACT []
is_a: GO:0141056 ! histone H4 ubiquitin ligase activity

[Term]
id: GO:0141002
name: histone H4K16 propionyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16)." [PMID:17267393, PMID:29321206, PMID:31794431]
is_a: GO:0061922 ! histone propionyltransferase activity

[Term]
id: GO:0141003
name: histone H2AX kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone variant H2AX." [GOC:bf]
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0141005
name: transposable element silencing by heterochromatin formation
namespace: biological_process
def: "A transposable element silencing mechanism involving heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription." [PMID:25247314, PMID:28951459, PMID:32823517]
synonym: "retrotransposon silencing by heterochromatin formation" NARROW []
is_a: GO:0010526 ! transposable element silencing
is_a: GO:0140719 ! constitutive heterochromatin formation

[Term]
id: GO:0141006
name: transposable element silencing by piRNA-mediated heterochromatin formation
namespace: biological_process
def: "A transposable element silencing mechanism in which a Piwi-associated RNA (piRNA) triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription." [PMID:32381626, PMID:32674113]
synonym: "piRNA-mediated retrotransposon silencing by heterochromatin formation" NARROW []
is_a: GO:0140966 ! piRNA-mediated heterochromatin formation
is_a: GO:0141005 ! transposable element silencing by heterochromatin formation

[Term]
id: GO:0141007
name: transposable element silencing by siRNA-mediated heterochromatin formation
namespace: biological_process
def: "A transposable element silencing mechanism in which a siRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription." [PMID:36570931]
synonym: "siRNA-mediated retrotransposon silencing by heterochromatin formation" NARROW []
is_a: GO:0141005 ! transposable element silencing by heterochromatin formation
is_a: GO:0141194 ! siRNA-mediated heterochromatin formation

[Term]
id: GO:0141008
name: transposable element silencing by mRNA destabilization
namespace: biological_process
def: "A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation." [GOC:curators]
synonym: "post-transcriptional retrotransposon silencing" EXACT []
synonym: "retrotransposon silencing by mRNA destabilization" NARROW []
is_a: GO:0010526 ! transposable element silencing
is_a: GO:0061157 ! mRNA destabilization

[Term]
id: GO:0141009
name: transposable element silencing by piRNA-mediated mRNA destabilization
namespace: biological_process
def: "A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a Piwi-associated RNA (piRNA)." [PMID:22121019]
synonym: "piRNA-mediated post-transcriptional retrotransposon silencing" EXACT []
synonym: "piRNA-mediated retrotransposon silencing by mRNA destabilization" NARROW []
is_a: GO:0140991 ! piRNA-mediated gene silencing by mRNA destabilization
is_a: GO:0141008 ! transposable element silencing by mRNA destabilization

[Term]
id: GO:0141010
name: transposable element silencing by siRNA-mediated DNA methylation
namespace: biological_process
def: "A transposable element silencing mechanism mediated by RNA-directed DNA methylation. RNA-directed DNA methylation is a gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription." [PMID:28633017, PMID:32381626, PMID:32719317, PMID:36570931]
synonym: "retrostransposon silencing by RdDM" EXACT []
synonym: "retrotransposon silencing by RNA-directed DNA methylation" RELATED []
synonym: "retrotransposon silencing by siRNA-directed DNA methylation" NARROW []
synonym: "transposable element silencing by siRNA-directed DNA methylation" EXACT []
is_a: GO:0080188 ! gene silencing by siRNA-directed DNA methylation
is_a: GO:0141005 ! transposable element silencing by heterochromatin formation

[Term]
id: GO:0141011
name: transposable element silencing by siRNA-mediated mRNA destabilization
namespace: biological_process
def: "A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a siRNA." [PMID:36570931]
synonym: "siRNA-mediated post-transcriptional retrotransposon silencing" EXACT []
synonym: "siRNA-mediated retrotransposon silencing by mRNA destabilization" NARROW []
is_a: GO:0141008 ! transposable element silencing by mRNA destabilization

[Term]
id: GO:0141013
name: purine nucleotide import into lysosome
namespace: biological_process
def: "The directed import of purine nucleotide from the cytosol, across the lysosomal membrane, into the lysosome." [PMID:18375752, PMID:23876310]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport

[Term]
id: GO:0141014
name: ribosome hibernation
namespace: biological_process
def: "A cellular process that results in the silencing of ribosomes in quiescent cells. Quiescence takes place when cells encounter unfavorable conditions and cease to grow in bacteria and yeast. It also takes place in some specialized cells in higher eukaryotes, such as eggs. Ribosomes in a hibernation state are kept silent via association with proteins with inhibitory and protective functions." [PMID:28468753, PMID:30177741, PMID:36653451]
is_a: GO:0017148 ! negative regulation of translation

[Term]
id: GO:0141016
name: G/T mismatch-specific thymine-DNA glycosylase activity
namespace: molecular_function
def: "Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site." [EC:3.2.2.29, PMID:12711670]
xref: EC:3.2.2.29
is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0141017
name: effector-mediated induction of cell cycle reactivation in host
namespace: biological_process
def: "A symbiont process in which a molecule secreted by the symbiont reactivates the host cell cycle, resulting in DNA synthesis and host cell division, and contributing to vegetative tumor formation." [PMID:25888589]
is_a: GO:0140418 ! effector-mediated perturbation of host process by symbiont
relationship: part_of GO:0051819 ! symbiont-mediated induction of tumor or growth in host

[Term]
id: GO:0141018
name: adhesion of symbiont to host via host extracellular matrix
namespace: biological_process
def: "The attachment of a symbiont to its host by binding to a component of the host extracellular matrix. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15228540, PMID:21270401, PMID:23586629]
synonym: "adhesion of symbiont to host extracellular matrix via collagen" NARROW []
synonym: "adhesion of symbiont to host extracellular matrix via fibronectin" NARROW []
synonym: "adhesion of symbiont to host extracellular matrix via integrin" NARROW []
synonym: "adhesion of symbiont to host extracellular matrix via laminin" NARROW []
synonym: "adhesion of symbiont to host extracellular matrix via vitronectin" NARROW []
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0141023
name: symbiont-mediated disruption of host cell-cell adhesion
namespace: biological_process
def: "A process in which a symbiont alters or subverts host cell adhesion ito its extracellular matrix. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators]
synonym: "disruption by symbiont of host cell-cell adhesion" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0141024
name: adhesion of symbiont to host cell surface via host membrane carbohydrate
namespace: biological_process
def: "The attachment of a symbiont to its host by binding to a carbohydrate on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15210807, PMID:19527885, PMID:30736336]
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0141025
name: adhesion of symbiont to host cell surface via host glycoprotein
namespace: biological_process
def: "The attachment of a symbiont to its host by binding to a glycoprotein on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12010488, PMID:15487949, PMID:17630833, PMID:29184850]
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0141026
name: adhesion of symbiont to host cell surface via host membrane cholesterol
namespace: biological_process
def: "The attachment of a symbiont to its host by binding to cholesterol on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17557817, PMID:23239883]
is_a: GO:0044650 ! adhesion of symbiont to host cell

[Term]
id: GO:0141027
name: symbiont-mediated perturbation of host actin cytoskeleton
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20688909]
synonym: "disruption by symbiont of actin cytoskeleton" RELATED []
synonym: "modification by symbiont of host actin cytoskeleton" RELATED []
synonym: "perturbation by symbiont of host actin cytoskeleton" EXACT []
is_a: GO:0052039 ! symbiont-mediated perturbation of host cytoskeleton

[Term]
id: GO:0141028
name: symbiont-mediated perturbation of host microtubule cytoskeleton
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host microtubule cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21692747, PMID:26220855]
synonym: "disruption by symbiont of host microtubule cytoskeleton" RELATED []
synonym: "modification by symbiont of host microtubule cytoskeleton" RELATED []
synonym: "perturbation by symbiont of host microtubule cytoskeleton" EXACT []
is_a: GO:0052039 ! symbiont-mediated perturbation of host cytoskeleton

[Term]
id: GO:0141029
name: symbiont-mediated disruption of host focal adhesion
namespace: biological_process
def: "A process in which a symbiont alters or subverts focal adhesion in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:19489119, PMID:24573681, PMID:24905543]
synonym: "disruption by symbiont of host focal adhesion" EXACT []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0141030
name: symbiont-mediated perturbation of host actin cytoskeleton via filamentous actin depolymerization
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by depolymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11889090, PMID:28800062]
is_a: GO:0141027 ! symbiont-mediated perturbation of host actin cytoskeleton

[Term]
id: GO:0141031
name: symbiont-mediated perturbation of host actin cytoskeleton via actin crosslinking
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by actin crosslinking the host actin filaments. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:14512630, PMID:22814176]
synonym: "perturbation by symbiont of host actin cytoskeleton via actin crosslinking" EXACT []
is_a: GO:0141027 ! symbiont-mediated perturbation of host actin cytoskeleton

[Term]
id: GO:0141032
name: symbiont-mediated perturbation of host actin cytoskeleton via actin filament reorganization
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by reorganizing the actin filaments, in a way that keeps the total filementous actin remains approximately constant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22212282, PMID:31130928]
synonym: "perturbation by symbiont of host actin cytoskeleton via actin filament rearrangement" EXACT []
synonym: "perturbation by symbiont of host actin cytoskeleton via actin filament reorganization" EXACT []
is_a: GO:0141027 ! symbiont-mediated perturbation of host actin cytoskeleton

[Term]
id: GO:0141033
name: symbiont-mediated perturbation of host actin cytoskeleton via actin polymerization
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by polymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18331467, PMID:25293534]
synonym: "perturbation by symbiont of host actin cytoskeleton via actin polymerization" EXACT []
is_a: GO:0141027 ! symbiont-mediated perturbation of host actin cytoskeleton

[Term]
id: GO:0141034
name: symbiont-mediated perturbation of host actin cytoskeleton via inhibition of actin polymerization
namespace: biological_process
def: "The process in which an organism effects a change that disrupts the host actin cytoskeleton by inhibiting host actin from polymerizing. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23409096, PMID:24253566, PMID:30297616]
synonym: "perturbation by symbiont of host actin cytoskeleton via inhibition of actin polymerization" EXACT []
is_a: GO:0141027 ! symbiont-mediated perturbation of host actin cytoskeleton

[Term]
id: GO:0141035
name: CTP-dependent diacylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H+." [RHEA:25948]
synonym: "DAG kinase activity" BROAD [EC:2.7.1.174]
synonym: "diacylglycerol kinase (CTP dependent)" BROAD [EC:2.7.1.174]
synonym: "diacylglycerol kinase activity" BROAD []
synonym: "diacylglycerol kinase activity (CTP)" EXACT []
xref: EC:2.7.1.174
xref: KEGG_REACTION:R09944
xref: MetaCyc:RXN-12959
xref: RHEA:25948
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0141038
name: phosphatidylinositol 3-kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K)." [PMID:31686003]
is_a: GO:0035014 ! phosphatidylinositol 3-kinase regulator activity

[Term]
id: GO:0141039
name: phosphatidylinositol 3-kinase inhibitor activity
namespace: molecular_function
def: "Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K)." [PMID:31686003]
is_a: GO:0035014 ! phosphatidylinositol 3-kinase regulator activity

[Term]
id: GO:0141040
name: very-long-chain 3-oxoacyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:48680]
xref: EC:1.1.1.330
xref: MetaCyc:RXN-7698
xref: Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA"
xref: RHEA:48680
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0141041
name: disruption of extracellular matrix of another organism
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the extracellular matrix of another organism." [PMID:2817904]
comment: Note that this process can occur during host-symbiont interactions or be mediated by toxin secreted by free-living organisms.
is_a: GO:0140975 ! disruption of cellular anatomical structure in another organism

[Term]
id: GO:0141042
name: symbiont-mediated cAMP intoxication of host cell
namespace: biological_process
def: "The production by a symbiont of high levels of cyclic AMP in a host cell, impairing host cellular functions in multiple ways, including ATP depletion, interference with host intracellular signaling, cytoskeletal defects and apoptosis-related cell death. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16390441, PMID:19516256, PMID:27731909, PMID:33013916]
synonym: "cAMP intoxication in host" EXACT []
is_a: GO:0052027 ! symbiont-mediated perturbation of host signal transduction pathway

[Term]
id: GO:0141043
name: symbiont-mediated evasion of host innate immune response
namespace: biological_process
def: "A process by which a symbiont avoids recognition by host's innate immune response by altering, concealing or destroying a conserved symbiont molecule recognized by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15014080, PMID:22131330, PMID:26502908, PMID:29101229]
synonym: "evasion of host innate immune recognition" RELATED []
synonym: "evasion of host innate immune response" EXACT []
is_a: GO:0042783 ! symbiont-mediated evasion of host immune response

[Term]
id: GO:0141044
name: epigenetic programming in the endosperm
namespace: biological_process
def: "The global programming of epigenetic modifications following binucleate central cell fertilization. This involves DNA methylation at the silent allele. In the endosperm, maternal genomes are hypomethylated compared with the paternal genome." [PMID:10580004, PMID:16469697, PMID:16527743, PMID:18700816, PMID:28118754]
synonym: "epigenetic reprogramming in the endosperm" EXACT []
is_a: GO:0044725 ! epigenetic programming in the zygotic pronuclei

[Term]
id: GO:0141046
name: Atg8-family conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of an Atg8 family modifier from one protein to a phosphatidylethanolamine or phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X." [PMID:11100732, PMID:17986448, PMID:18704115, PMID:28234446, PMID:33909989]
synonym: "APG8 conjugating enzyme activity" EXACT []
synonym: "Atg8 conjugating enzyme activity" NARROW []
synonym: "Atg8-like conjugating activity" EXACT []
synonym: "E2" BROAD []
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity

[Term]
id: GO:0141047
name: molecular tag activity
namespace: molecular_function
def: "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [PMID:17632063]
comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.
synonym: "covalent modifier" BROAD []
synonym: "tag" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0141048
name: membrane tag activity
namespace: molecular_function
def: "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy." [PMID:17632063]
comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.
synonym: "covalent modifier" BROAD []
synonym: "lipid tag" EXACT []
is_a: GO:0141047 ! molecular tag activity

[Term]
id: GO:0141049
name: protein-glutathione oxidoreductase (glutathione) activity
namespace: molecular_function
def: "Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism." [PMID:23397885, PMID:33932870, PMID:36771108]
synonym: "glutaredoxin activity" BROAD []
synonym: "glutathione oxidoreductase activity" BROAD []
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0141050
name: histone H3K deacetylase activity
namespace: molecular_function
def: "Removal of an acetyl group from a lysine residue in a histone H3." [GOC:pg, PMID:9893272]
comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
is_a: GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0141051
name: histone H4K deacetylase activity
namespace: molecular_function
def: "Removal of an acetyl group from a lysine residue in a histone H4." [PMID:12590135]
comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
is_a: GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0141052
name: histone H3 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17947579]
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0141053
name: histone H2A ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of ubiquitin to a histone H2A substrate." [PMID:25303536]
is_a: GO:0140852 ! histone ubiquitin ligase activity

[Term]
id: GO:0141054
name: histone H2B ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of ubiquitin to a histone H2B substrate." [PMID:25303536]
is_a: GO:0140852 ! histone ubiquitin ligase activity

[Term]
id: GO:0141055
name: histone H3 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of ubiquitin to a histone H3 substrate." [PMID:25303536]
is_a: GO:0140852 ! histone ubiquitin ligase activity

[Term]
id: GO:0141056
name: histone H4 ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of ubiquitin to a histone H4 substrate." [PMID:25303536]
is_a: GO:0140852 ! histone ubiquitin ligase activity

[Term]
id: GO:0141057
name: histone H3 arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination." [PMID:25303536]
is_a: GO:0140794 ! histone arginine deiminase activity

[Term]
id: GO:0141058
name: histone H4 demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17947579]
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0141059
name: symbiont-mediated disruption of host antimicrobial peptide activity
namespace: biological_process
def: "Any process in which a symbiont interferes with a host antimicrobial peptide, for example by cleavage or degradation." [PMID:16242332, PMID:19015361, PMID:21335044]
synonym: "disruption of host antimicrobial peptide activity" EXACT []
is_a: GO:0044414 ! symbiont-mediated suppression of host defenses

[Term]
id: GO:0141060
name: disruption of anatomical structure in another organism
namespace: biological_process
def: "The disruption of an anatomical structure of another organism, leading to damage or temporary subversion of that structure." [GOC:pg]
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0141061
name: disruption of cell in another organism
namespace: biological_process
def: "The disruption of a cell of another organism, leading to damage or temporary subversion of that cell." [GOC:pg]
is_a: GO:0141060 ! disruption of anatomical structure in another organism

[Term]
id: GO:0141062
name: disruption of tissue in another organism
namespace: biological_process
def: "The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue." [PMID:11895956, PMID:26355030, PMID:27416066, PMID:28194160, PMID:34346770]
synonym: "tissue necrosis in another organism" EXACT []
is_a: GO:0141060 ! disruption of anatomical structure in another organism

[Term]
id: GO:0141063
name: epigenetic programming in the central cell
namespace: biological_process
def: "The establishment of epigenetic modifications (imprints) in a plant central cell, leading to an asymmetry between the two maternal alleles and the paternal allele, and differential expression of the corresponding alleles in the developing endosperm. This can happen through heterochromatin formation or differential chromatin loop formation." [PMID:28118754]
is_a: GO:0071514 ! genomic imprinting

[Term]
id: GO:0141064
name: zygotic genome activation
namespace: biological_process
def: "A process that contributes to the onset of de novo transcription from the zygotic genome as part of the maternal-to-zygote transition in gene expression. The zygote overcomes the silencing that has been established. The cause of this silencing could be due to several factors: chromatin modifications leading to repression, or lack of adequate transcription machinery." [PMID:19204068, PMID:20808952]
synonym: "ZGA" BROAD []
is_a: GO:0010628 ! positive regulation of gene expression
relationship: part_of GO:0160021 ! maternal-to-zygotic transition of gene expression

[Term]
id: GO:0141065
name: maternal mRNA clearance
namespace: biological_process
def: "The chemical reactions and pathways resulting in the clearance of maternal mRNA transcripts from the zygote as part of the maternal-to-zygote transition in gene expression." [PMID:19204068, PMID:32558204]
synonym: "maternal mRNA degradation" EXACT []
synonym: "maternal transcript clearance" EXACT []
synonym: "maternal transcript degradation" EXACT []
is_a: GO:0006402 ! mRNA catabolic process
relationship: part_of GO:0160021 ! maternal-to-zygotic transition of gene expression

[Term]
id: GO:0141066
name: symbiont-mediated disruption of host extracellular matrix
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of the host extracellular matrix." [PMID:11982763, PMID:21115719, PMID:2404867, PMID:25865874]
synonym: "disruption of host extracellular matrix" BROAD []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure
is_a: GO:0141041 ! disruption of extracellular matrix of another organism

[Term]
id: GO:0141067
name: intracellular nitrogen homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of nitrogen within a cell." [GOC:tb]
synonym: "cellular nitrogen homeostasis" EXACT []
synonym: "nitrogen homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis

[Term]
id: GO:0141068
name: autosome genomic imprinting
namespace: biological_process
def: "The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation." [PMID:31782494]
synonym: "autosomal genomic imprinting" EXACT []
synonym: "genomic imprinting of autosomal genes" EXACT []
is_a: GO:0071514 ! genomic imprinting

[Term]
id: GO:0141069
name: receptor ligand inhibitor activity
namespace: molecular_function
def: "Binds to and decreases the activity of the ligand of a signaling receptor." [PMID:12478285, PMID:1721860]
synonym: "signaling receptor ligand inhibitor activity" EXACT []
is_a: GO:0140678 ! molecular function inhibitor activity

[Term]
id: GO:0141070
name: symbiont-mediated suppression of host MAPK cascade
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a MAPK signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18005697]
synonym: "disruption of host MAP kinase signaling pathway" EXACT []
synonym: "disruption of host MAPK signal transduction pathway" EXACT []
synonym: "disruption of host MAPK signaling pathway" EXACT []
synonym: "symbiont-mediated suppression of host MAPK signal transduction pathway" EXACT []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway
is_a: GO:0052080 ! symbiont-mediated perturbation of host MAPK cascade

[Term]
id: GO:0141071
name: symbiont-mediated activation of host MAPK cascade
namespace: biological_process
def: "A process in which a symbiont subverts a MAPK signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24043761, PMID:25675415, PMID:28166272]
synonym: "activation by symbiont of host MAPK signal transduction pathway" NARROW []
synonym: "induction by symbiont of host MAP kinase signal transduction pathway" EXACT []
synonym: "induction of host MAPK kinase signaling pathway" EXACT []
synonym: "stimulation by symbiont of host MAPK signal transduction pathway" NARROW []
synonym: "symbiont-mediated activation of host MAPK signal transduction pathway" EXACT []
is_a: GO:0052028 ! symbiont-mediated activation of host signal transduction pathway
is_a: GO:0052080 ! symbiont-mediated perturbation of host MAPK cascade

[Term]
id: GO:0141072
name: symbiont-mediated suppression of host tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "A process in which a virus interferes with, inhibits or disrupts a tumor necrosis factor-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11805081, PMID:24736233]
synonym: "disruption of host TNF-mediated signaling pathway" EXACT []
synonym: "disruption of host TNFR-mediated signaling pathway" EXACT []
synonym: "disruption of host tumor necrosis factor receptor-mediated signaling pathway" EXACT []
synonym: "disruption of host tumor necrosis factor-mediated signaling pathway" EXACT []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0141073
name: symbiont-mediated perturbation of host opsonization
namespace: biological_process
def: "A process in which a symbiont alters or subverts opsonization by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18068388, PMID:18941224, PMID:2307127, PMID:28860090]
synonym: "disruption by symbiont of host opsonization" EXACT []
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0141074
name: symbiont-mediated suppression of host cGAS-STING signal transduction
namespace: biological_process
def: "A process in which a virus interferes with, inhibits or disrupt a cGAS/STING signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:26405230, PMID:27234299, PMID:29018427]
synonym: "disruption of host cGAS-STING signal transduction" EXACT []
synonym: "disruption of host cGAS-STING signaling" EXACT []
synonym: "suppression of host cGAS-STING" EXACT []
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0141075
name: obsolete suppression of host JAK-STAT cascade
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20624917, PMID:22919663, PMID:27437422, PMID:29924996, PMID:31413201]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host JAK-STAT cascade ; GO:0039514.
synonym: "disruption of host JAK-STAT cascade" EXACT []
synonym: "down-regulation of host JAK-STAT cascade" EXACT [GOC:bf]
synonym: "downregulation of host JAK-STAT cascade" EXACT [GOC:bf]
synonym: "inhibition of host JAK-STAT cascade" NARROW []
synonym: "negative regulation of host JAK-STAT cascade" EXACT [GOC:bf]
synonym: "suppression of host JAK-STAT cascade" EXACT []
synonym: "symbiont-mediated suppression of host JAK-STAT cascade" RELATED []
is_obsolete: true
replaced_by: GO:0039514

[Term]
id: GO:0141076
name: obsolete suppression of host TRAF-mediated signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20335533, PMID:22407319, PMID:31311877]
comment: This term was obsoleted because it was redundant with symbiont-mediated suppression of host TRAF-mediated signal transduction ; GO:0039527.
synonym: "disruption of host TRAF-mediated signal transduction" EXACT []
synonym: "inhibition of host TRAF-mediated signal transduction" EXACT []
synonym: "inhibition of host TRAFs" NARROW []
synonym: "negative regulation of host TRAF-mediated signal transduction" EXACT []
synonym: "suppression of host TRAF activity" NARROW []
synonym: "suppression of host TRAF-mediated signal transduction" EXACT []
synonym: "suppression of host tumor necrosis factor receptor-associated factor signaling" EXACT []
synonym: "symbiont-mediated suppression of host TRAF-mediated signal transduction" RELATED []
is_obsolete: true

[Term]
id: GO:0141077
name: obsolete suppression of host interferon-mediated signaling pathway
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts an interferon-mediated signaling in the host organism." [PMID:31266861, PMID:34305858]
comment: This term was obsoleted because it represents the same concept as suppression of host interferon-mediated signaling pathway ; GO:0140886.
synonym: "inhibition of host interferon signaling pathway" RELATED []
synonym: "negative regulation of host interferon-mediated signaling pathway" EXACT []
synonym: "suppression of host IFN-mediated signaling pathway" EXACT []
synonym: "suppression of host interferon-mediated signaling pathway" NARROW []
synonym: "symbiont-mediated of host interferon-mediated signaling pathway" RELATED []
is_obsolete: true
replaced_by: GO:0140886

[Term]
id: GO:0141078
name: obsolete symbiont-mediated suppression of host RIG-I signaling pathway
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a RIG-I signaling pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:19936053]
comment: This term was obsoleted because it was created by mistake; it represents the same process as symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity ; GO:0039540.
synonym: "disruption of host RIG-1 signaling pathway" EXACT []
synonym: "disruption of host RIG-I signaling pathway" EXACT []
is_obsolete: true
replaced_by: GO:0039540

[Term]
id: GO:0141079
name: symbiont-mediated activation of host inflammasome-mediated signal transduction
namespace: biological_process
def: "A process in which a symbiont subverts an inflammasome-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:25538194, PMID:28331908, PMID:30872531, PMID:34155776]
synonym: "perturbation of host inflammasome-mediated signal transduction" BROAD []
is_a: GO:0052028 ! symbiont-mediated activation of host signal transduction pathway

[Term]
id: GO:0141080
name: symbiont-mediated activation of host interferon signaling pathway
namespace: biological_process
def: "A process in which a symbiont subverts an interferon-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation." [PMID:26553469, PMID:29076073]
is_a: GO:0052028 ! symbiont-mediated activation of host signal transduction pathway

[Term]
id: GO:0141081
name: symbiont-mediated suppression of host inflammasome-mediated signal transduction
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or stops an inflammasome-mediated signal transduction pathway in the host organism by interfering with its normal execution. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:26687278, PMID:27214553, PMID:29061850, PMID:34324582, PMID:36227980]
synonym: "perturbation of host inflammasome-mediated signal transduction" BROAD []
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

[Term]
id: GO:0141082
name: symbiont-mediated detoxification of host-generated reactive oxygen species
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts the host reactive oxygen species (ROS)-mediated innate immune response by directly degrading host ROS. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:19684141, PMID:27825304, PMID:28288207]
is_a: GO:0052164 ! symbiont defense to host-produced reactive oxygen species

[Term]
id: GO:0141083
name: symbiont-mediated suppression of host reactive oxygen species generation
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts the host signal transduction pathways leading to the production of reactive oxygen species as part of the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:27473656, PMID:31375544]
synonym: "inhibition by organism of defense-related host active oxygen species production" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0141084
name: inflammasome-mediated signaling pathway
namespace: biological_process
def: "An intracellular signal transduction pathway that starts with a ligand binding to a pattern recognition receptor (PRR), assembly of the inflammasome complex, leading to the activation of CASP1 and inducing an inflammatory response. In some cases, inflammasome-mediated signal transduction can lead to programmed cell death, such as pyroptosis." [PMID:35883561]
synonym: "inflammasome-mediated signal transduction" EXACT []
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0141085
name: regulation of inflammasome-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an inflammasome-mediated signaling pathway." [PMID:33467177]
synonym: "regulation of inflammasome-mediated signal transduction" EXACT []
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: regulates GO:0141084 ! inflammasome-mediated signaling pathway

[Term]
id: GO:0141086
name: negative regulation of inflammasome-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an inflammasome-mediated signaling pathway." [PMID:33467177]
synonym: "negative regulation of inflammasome-mediated signal transduction" EXACT []
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0141085 ! regulation of inflammasome-mediated signaling pathway
relationship: negatively_regulates GO:0141084 ! inflammasome-mediated signaling pathway

[Term]
id: GO:0141087
name: positive regulation of inflammasome-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an inflammasome-mediated signaling pathway." [PMID:33467177]
synonym: "positive regulation of inflammasome-mediated signal transduction" EXACT []
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:0141085 ! regulation of inflammasome-mediated signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0141084 ! inflammasome-mediated signaling pathway

[Term]
id: GO:0141088
name: obsolete symbiont-mediated activation of host autophagy
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont initiates, promotes, or enhances the activation of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pg]
comment: This term was obsoleted because it represents the same process as symbiont-mediated activation of host autophagy ; GO:0039520.
synonym: "induction of host autophagy" EXACT []
synonym: "positive regulation by symbiont of host autophagy" EXACT []
is_obsolete: true
replaced_by: GO:0039520

[Term]
id: GO:0141089
name: glucose sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose." [PMID:17470517]
synonym: "glucose sensing activity" EXACT []
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0141090
name: protein serine pyrophosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate." [PMID:36603579, RHEA:64104]
synonym: "protein serine pyrophosphatase activity" RELATED []
xref: RHEA:64104
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0141091
name: transforming growth factor beta receptor superfamily signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268]
synonym: "TGF-beta receptor superfamily signaling pathway" EXACT []
synonym: "TGF-beta receptor superfamily signalling pathway" EXACT []
synonym: "TGFbeta receptor superfamily signaling pathway" EXACT []
synonym: "TGFbeta receptor superfamily signalling pathway" EXACT []
synonym: "transforming growth factor beta receptor superfamily signalling pathway" EXACT []
is_a: GO:0007178 ! cell surface receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0141092
name: positive regulation of nodal signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of nodal signaling pathway." [PMID:17239842]
is_a: GO:0032927 ! positive regulation of activin receptor signaling pathway
is_a: GO:1900107 ! regulation of nodal signaling pathway
relationship: positively_regulates GO:0038092 ! nodal signaling pathway

[Term]
id: GO:0141093
name: 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine." [PMID:11948155, PMID:23072415, PMID:25781338, RHEA:55200]
xref: EC:2.5.1.147
xref: MetaCyc:RXN-19229
xref: RHEA:55200
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0141094
name: DNA loop anchor binding
namespace: molecular_function
def: "Binding to a DNA loop anchor, a region of chromosome that defines the ends of a DNA loop where two parts of same DNA strand are held in close physical proximity. For example, in animals, the anchors of DNA loops are convergently oriented CTCF binding sites during interphase." [PMID:25497547, PMID:26499245]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0141095
name: obsolete retrotransposon silencing by DNA methylation-dependent heterochromatin formation
namespace: biological_process
def: "OBSOLETE. A retrotransposon silencing mechanism in which a methylated cytosine residues in the genome promote heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription." [PMID:15318244]
comment: This term was obsoleted because it represent the same pathway as retrotransposon silencing by siRNA-directed DNA methylation ; GO:0141010.
is_obsolete: true
replaced_by: GO:0141010

[Term]
id: GO:0141096
name: ligand-modulated transcription repressor activity
namespace: molecular_function
def: "A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets." [PMID:21555518]
synonym: "ligand-activated transcription repressor activity" NARROW []
is_a: GO:0001217 ! DNA-binding transcription repressor activity
is_a: GO:0098531 ! ligand-modulated transcription factor activity

[Term]
id: GO:0141097
name: ligand-modulated transcription activator activity
namespace: molecular_function
def: "A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets." [GOC:pg]
synonym: "ligand-activated transcription activator activity" NARROW []
is_a: GO:0001216 ! DNA-binding transcription activator activity
is_a: GO:0098531 ! ligand-modulated transcription factor activity

[Term]
id: GO:0141098
name: tRNA (cytidine(34)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H+ + S-adenosyl-L-homocysteine." [PMID:31943105, RHEA:43084]
synonym: "tRNA (cytidine 34-2'-O)-methyltransferase activity" EXACT []
xref: RHEA:43084
is_a: GO:0016427 ! tRNA (cytidine) methyltransferase activity

[Term]
id: GO:0141100
name: tRNA (guanine(18)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 18 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 18 in tRNA + H+." [PMID:25404562]
synonym: "tRNA (guanosine(18)-2'-O)-methyltransferase activity" EXACT []
xref: EC:2.1.1.34
xref: MetaCyc:2.1.1.34-RXN
xref: RHEA:20077
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0141101
name: tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + uridine44 in tRNASer = 2'-O-methyluridine44 in tRNASer + H+ + S-adenosyl-L-homocysteine." [PMID:18025252, RHEA:43100]
synonym: "tRNA(Ser) (uracil(44)-2'-O-)-methyltransferase activity" EXACT []
xref: EC:2.1.1.211
xref: MetaCyc:RXN-12368
xref: Reactome:R-HSA-6788707 "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser)"
xref: RHEA:43100
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity

[Term]
id: GO:0141102
name: tRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxymethylaminomethyluridine34 in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu) + H+ + S-adenosyl-L-homocysteine." [PMID:20855540, RHEA:43088]
synonym: "tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase activity" EXACT []
xref: RHEA:43088
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity

[Term]
id: GO:0141104
name: symbiont-mediated activation of host G protein-coupled receptor signal transduction
namespace: biological_process
def: "A process in which a symbiont initiates, promotes, or enhances a G protein-coupled receptor signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15963708, PMID:18978047, PMID:25332123]
is_a: GO:0052028 ! symbiont-mediated activation of host signal transduction pathway
is_a: GO:0075118 ! symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway

[Term]
id: GO:0141105
name: obsolete suppression of host toll-like receptor signal transduction
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a toll-like receptor signaling pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15944308, PMID:17299722, PMID:18327267]
comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host toll-like receptor signal transduction ; GO:0039722.
synonym: "symbiont-mediated disruption of host toll-like receptor signaling pathway" EXACT []
synonym: "symbiont-mediated suppression of host toll-like receptor signal transduction" RELATED []
synonym: "symbiont-mediated suppression of host toll-like receptor signaling pathway" EXACT []
is_obsolete: true
replaced_by: GO:0039722

[Term]
id: GO:0141106
name: tRNA methyltransferase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a methyltransferase." [GOC:curators]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0141107 ! methyltransferase regulator activity

[Term]
id: GO:0141107
name: methyltransferase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a methyltransferase." [PMID:15899842, PMID:34669960]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0141108
name: transporter regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a transporter." [GOC:curators]
is_a: GO:0098772 ! molecular function regulator activity

[Term]
id: GO:0141109
name: transporter activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a transporter." [GOC:curators]
is_a: GO:0140677 ! molecular function activator activity
is_a: GO:0141108 ! transporter regulator activity

[Term]
id: GO:0141110
name: transporter inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents, or reduces the activity of a transporter." [GOC:curators]
is_a: GO:0140678 ! molecular function inhibitor activity
is_a: GO:0141108 ! transporter regulator activity

[Term]
id: GO:0141111
name: positive regulation of cGAS/STING signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of of cGAS/STING signaling pathway." [PMID:37802025]
is_a: GO:0039531 ! regulation of cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0140896 ! cGAS/STING signaling pathway

[Term]
id: GO:0141112
name: broken chromosome clustering
namespace: biological_process
def: "The process of bringing together chromosomes fragments resulting from DNA damage. Broken chromosome tethering during mitosis ensures clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss and enhancing genome integrity." [PMID:37165191, PMID:37316668]
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006974 ! DNA damage response

[Term]
id: GO:0141113
name: negative regulation of Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway, planar cell polarity pathway." [PMID:19056682]
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway
relationship: negatively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway

[Term]
id: GO:0141114
name: obsolete symbiont-mediated suppression of host complement activation
namespace: biological_process
def: "OBSOLETE. A process by which a symbiont inhibits or disrupts the normal execution of the activation of complement in its host." [PMID:20194595, PMID:25830295]
comment: This term was obsoleted because it represents the same process as GO:0042784.
synonym: "suppression of complement activation by another organism" BROAD []
is_obsolete: true
replaced_by: GO:0042784

[Term]
id: GO:0141115
name: symbiont-mediated suppression of host complement activation by inactivation of complement proteins
namespace: biological_process
def: "A process by which a symbiont disrupts or prematurely activates host complement so that its microbial-destroying activities fail." [PMID:24312361, PMID:34305859]
synonym: "suppression of complement activation by another organism by inactivation of complement proteins" BROAD []
is_a: GO:0042784 ! symbiont-mediated suppression of host complement activation

[Term]
id: GO:0141116
name: symbiont-mediated suppression of host complement activation by complement sequestering
namespace: biological_process
def: "A process by which a symbiont prevents host complement activation by sequestering it away from its surface." [PMID:18323455]
synonym: "suppression of complement activation by another organism by complement sequestering" BROAD []
is_a: GO:0042784 ! symbiont-mediated suppression of host complement activation

[Term]
id: GO:0141117
name: symbiont-mediated suppression of host complement activation by recruitment of complement control protein
namespace: biological_process
def: "A process by which a symbiont prevents the activation of host complement by binding a soluble complement control protein (CCP) of the host and recruiting it to the microbe surface. The normal role of CCPs is to prevent complement activation on 'self' cellular targets. When soluble CCPs are recuited to the surface of a microbe, the complement fails to activate." [PMID:17513779, PMID:22540535, PMID:24129254, PMID:27304426]
synonym: "suppression of complement activation by another organism by recruitment of complement control protein" BROAD []
synonym: "suppression of complement activation by another organism by recuitement of complement control protein" EXACT []
is_a: GO:0042784 ! symbiont-mediated suppression of host complement activation

[Term]
id: GO:0141118
name: nitric oxide dioxygenase activity, heme protein as donor
namespace: molecular_function
def: "Catalysis of the reaction: Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate." [PMID:20511233]
comment: Note that this activity is similar to nitric oxide dioxygenase activity ; GO:0008941, but GO:000894 uses NADPH as the electron donor.
xref: RHEA:78091
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors

[Term]
id: GO:0141119
name: chromosomal DNA methylation maintenance following DNA replication
namespace: biological_process
def: "The process that maintains methylated cytosine in newly synthesized DNA following DNA replication. After the establishment of novel DNA methylation marks, the newly created patterns must be faithfully transmitted by maintenance DNA methyltransferases during cell division." [PMID:11005794, PMID:20142834, PMID:26077819, PMID:34968368]
comment: CG methylation is maintained by two evolutionarily conserved core partners: (1) a maintenance DNA methyltransferase called DNMT1 in mammals and MET1 (DNA METHYLTRANSFERASE 1) in plants and (2) a cofactor named UHRF1 in mammals and VIM (VARIANT IN METHYLATION) in plants. In mammals, the maintenance of non-CG methylation typically involves DNMT3 enzymes. In plants, non-CG methylation is further divided in two classes of sequence, CHG and CHH, and requires distinct enzymatic machineries.
synonym: "DNA methylation" BROAD []
synonym: "DNA methylation maintenance" BROAD []
synonym: "DNA methylation maintenance following cell division" EXACT []
synonym: "DNA methylation maintenance following DNA replication" EXACT []
synonym: "genome methylation maintenance following DNA replication" EXACT []
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0141122
name: nitrogen-oxygen hydrolyase activity
namespace: molecular_function
def: "Catalysis of the breakage of a nitrogen-oxygen bond by means other than hydrolysis and oxidation." [EC:4.8.1.-]
xref: EC:4.8.1.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0141123
name: dermonecrosis in another organism
namespace: biological_process
def: "The disruption of the skin of another organism, leading to damage or temporary subversion of the skin." [PMID:28194160]
is_a: GO:0141062 ! disruption of tissue in another organism

[Term]
id: GO:0141124
name: intracellular signaling cassette
namespace: biological_process
def: "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]
synonym: "intracellular signaling cascade" EXACT []
synonym: "intracellular signaling module" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0141125
name: tRNA-queuosine(34) galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: queuosine34 in tRNA + UDP-alpha-D-galactose = H+ + O-5''-beta-D-galactosylqueuosine34 in tRNATyr + UDP. Substrates include tRNA(Tyr) and tRNA(Asp)." [PMID:37992713]
synonym: "tRNA queuosine galactosyltransferase activity" BROAD []
synonym: "tRNA queuosine(34) galactosyltransferase activity" EXACT []
xref: RHEA:78231
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0141126
name: short-chain fatty acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a short-chain fatty acyl-CoA + H2O = a short fatty acid + CoA + H+. A short-chain fatty acid has an aliphatic tail of less than 6 carbons." [RHEA:68180]
comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
xref: MetaCyc:3.1.2.18-RXN
xref: RHEA:68180
is_a: GO:0047617 ! fatty acyl-CoA hydrolase activity

[Term]
id: GO:0141127
name: symbiont-mediated perturbation of host Rab small GTPase signal transduction
namespace: biological_process
def: "A process in which a symbiont alters a Rab protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24251537, PMID:30181274, PMID:30893609]
synonym: "modulation by symbiont of host Rab protein mediated signal transduction" EXACT []
synonym: "modulation by symbiont of host Rab protein signal transduction" EXACT []
synonym: "modulation by symbiont of host Rab protein-mediated signal transduction" EXACT []
synonym: "modulation of host Rab protein signal transduction by symbiont" EXACT []
synonym: "modulation of host Rab protein signaling by symbiont" EXACT []
synonym: "modulation of host Rab protein signalling by symbiont" EXACT []
synonym: "perturbation of host Rab protein signal transduction" EXACT []
synonym: "symbiont-mediated perturbation of host Rab protein signal transduction" EXACT []
is_a: GO:0044082 ! symbiont-mediated perturbation of host small GTPase-mediated signal transduction

[Term]
id: GO:0141128
name: symbiont-mediated non-specific activation of host T-cells
namespace: biological_process
def: "A process by which a symbiont superantigen elicits a strong immune response by activating a large number of T cells in a non-specific manner. Unlike conventional antigens, which activate T cells by interacting with specific receptors on the surface of these cells, superantigens can stimulate T cells by binding to regions outside the antigen-binding site. Superantigens can activate a large proportion of T cells, leading to an exaggerated immune response. This excessive activation can result in the release of a large amount of cytokines such as tumor necrosis factor and interleukin-2. The massive cytokine release can lead to an acute toxic shock, causing symptoms such as fever and organ damage." [PMID:12679262, PMID:17427250, PMID:28880920]
synonym: "symbiont-mediated non-specific T-cell activation in host" EXACT []
synonym: "symbiont-mediated nonspecific activation of host T-cells" EXACT []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response

[Term]
id: GO:0141129
name: symbiont-mediated suppression of host signal transduction pathway via antagonism of host cell surface receptor
namespace: biological_process
def: "A process by which a symbiont alters or subverts a host cell surface receptor-mediated signal transduction pathway by binding to and inhibiting the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:10221874, PMID:22714643]
synonym: "symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor" BROAD []
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway

[Term]
id: GO:0141130
name: symbiont-mediated inactivation of host ribosome
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts translation of mRNA into protein in its host by inactivating its ribosomes." [PMID:1324134]
synonym: "symbiont-mediated host ribosome inactivation" EXACT []
is_a: GO:0039604 ! symbiont-mediated suppression of host translation

[Term]
id: GO:0141131
name: DNA N6-methyladenine demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + an N6-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate." [RHEA:49524]
synonym: "DNA N(6)-methyladenine demethylase activity" EXACT []
xref: EC:1.14.11.51
xref: RHEA:49524
is_a: GO:0035514 ! DNA demethylase activity

[Term]
id: GO:0141132
name: obsolete defense response to host
namespace: biological_process
alt_id: GO:0052264
alt_id: GO:0052348
alt_id: GO:0052369
def: "OBSOLETE. Reactions triggered in response to the presence of a host that act to protect or prevent damage to the symbiont." [GOC:curators]
comment: This term was obsoleted because it represents an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:0141133
name: diphthine methyl ester synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H+ + 4 S-adenosyl-L-homocysteine." [PMID:24739148, RHEA:42652]
comment: This activity is present in eukaryotes and is part of the biosynthetic pathway of diphthamide. Note that this is different from the archaeal enzyme, diphthine synthase activity ; GO:0004164 (EC:2.1.1.98), which performs only 3 methylations, producing diphthine.
xref: EC:2.1.1.314
xref: MetaCyc:RXN-15775
xref: Reactome:R-HSA-5358484 "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2"
xref: RHEA:42652
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0141134
name: symbiont-mediated activation of host signal transduction pathway via agonism of host cell surface receptor
namespace: biological_process
def: "A process in which a symbiont subverts a signal transduction pathway in the host organism by binding to and enhancing the activation of the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:10221874, PMID:18563600]
synonym: "symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor" BROAD []
is_a: GO:0052028 ! symbiont-mediated activation of host signal transduction pathway

[Term]
id: GO:0141135
name: symbiont-mediated suppression of host chemokine signal transduction pathway
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a chemokine signaling pathway, a G protein-coupled receptor signal transduction pathway activated by a chemokine. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16581912]
is_a: GO:0075120 ! symbiont-mediated suppression of host G protein-coupled receptor signal transduction

[Term]
id: GO:0141137
name: positive regulation of gene expression, epigenetic
namespace: biological_process
def: "An epigenetic process that increases gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA demethylation." [PMID:36618446]
synonym: "activation of gene expression, epigenetic" EXACT []
synonym: "up regulation of gene expression, epigenetic" EXACT []
synonym: "up-regulation of gene expression, epigenetic" EXACT []
synonym: "upregulation of gene expression, epigenetic" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0040029 ! epigenetic regulation of gene expression

[Term]
id: GO:0141139
name: symbiont-mediated disruption of host mucosa
namespace: biological_process
def: "The disruption of the host mucosa by a symbiont, leading to damage or temporary subversion of that tissue. The mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs." [PMID:22520462, PMID:28598765, PMID:28764997]
is_a: GO:0141146 ! symbiont-mediated disruption of host tissue

[Term]
id: GO:0141140
name: symbiont-mediated suppression of host immunoglobulin-mediated immune response
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts the normal execution of the immunoglobulin-mediated immune response of the host organism. One common mechanism by which this happens is the direct inhibition of immunoglobulin activity, by direct binding or modification. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18426869, PMID:22256861, PMID:24753590]
synonym: "symbiont-mediated suppression of host immunoglobulin activity" RELATED []
is_a: GO:0052562 ! symbiont-mediated suppression of host immune response

[Term]
id: GO:0141141
name: symbiont-mediated evasion of recognition by host pattern recognition receptor
namespace: biological_process
def: "A process by which a symbiont avoids recognition by host's innate immune response by altering or concealing a conserved molecule recognized by the host's cell surface and intracellular pattern recognition receptors, including Toll-like and NOD-like receptors. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17215377, PMID:26502908, PMID:29101229]
comment: Note that this term should be used when the symbiont in cases where the symbiont modifies its own molecules (proteins, DNA, RNA, lipids) to avoid recognition by the host. In cases where the symbiont  directly inhibits a component of a host cytoplasmic receptor signaling pathway, consider annotating to evasion of symbiont recognition by host pattern recognition receptor ; GO:0039537.
synonym: "evasion of symbiont recognition by host pattern recognition receptor" EXACT []
is_a: GO:0141043 ! symbiont-mediated evasion of host innate immune response

[Term]
id: GO:0141142
name: symbiont-mediated migration across host tissue barrier
namespace: biological_process
def: "A process in which a symbiont moves across a tissue barrier of the host to transports itself across an extracellular cellular matrix barrier or between the cells of a tissue. This involves the temporary or permanent breaching of the tissue barrier." [PMID:19820089, PMID:20188700, PMID:26681776, PMID:29120408]
is_a: GO:0044001 ! migration in host

[Term]
id: GO:0141143
name: obsolete symbiont-mediated disruption of host cell adhesion to extracellular matrix
namespace: biological_process
def: "OBSOLETE. A process in which a symbiont alters or subverts cell adhesion to the extracellular matrix in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22534208, PMID:30345086]
comment: This term was obsoleted because it was created by mistake.
synonym: "disruption by symbiont of host cell adhesion to extracellular matrix" EXACT []
is_obsolete: true
replaced_by: GO:0141146

[Term]
id: GO:0141144
name: symbiont-mediated disruption of host neutrophil extracellular traps
namespace: biological_process
def: "A process in which a symbiont damages or impairs host neutrophil extracellular traps. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16488875, PMID:21231972, PMID:25605868]
synonym: "symbiont-mediated perturbation of host neutrophil extracellular traps" EXACT []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0141145
name: symbiont-mediated suppression of host neutrophil extracellular trap formation
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the formation of neutrophil extracellular traps by the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:30038902, PMID:34108482]
synonym: "symbiont-mediated perturbation of host neutrophil extracellular trap formation" RELATED []
synonym: "symbiont-mediated suppression of host neutrophil extracellular traps formation" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0141146
name: symbiont-mediated disruption of host tissue
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of a host tissue. This can occur via the disruption of the extracellular matrix, or the detachment of cells from the extracellular matrix, or the dissociation of the cells composing that tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11982763, PMID:14651638, PMID:26355030]
synonym: "cytopathogenic effect" RELATED []
is_a: GO:0052111 ! symbiont-mediated disruption of host anatomical structure

[Term]
id: GO:0141147
name: intracellularly calcium-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens when calcium ions bind on the intracellular side of the channel complex or one of its constituent parts." [PMID:20929730, PMID:23021213]
is_a: GO:0022834 ! ligand-gated channel activity

[Term]
id: GO:0141148
name: enoyl-[acyl-carrier-protein] reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH." [RHEA:22564]
comment: This reaction completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. Note that EC has reaction describing the stereo-specificity of the reaction with respect to NADP+ (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.9).
xref: EC:1.3.1.104
xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN
xref: RHEA:22564
is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)

[Term]
id: GO:0141149
name: regulation of nitric oxide-cGMP mediated signal transduction
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction." [PMID:35931019]
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
relationship: regulates GO:0038060 ! nitric oxide-cGMP-mediated signaling

[Term]
id: GO:0141150
name: positive regulation of nitric oxide-cGMP mediated signal transduction
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction." [PMID:14615391]
is_a: GO:0010750 ! positive regulation of nitric oxide mediated signal transduction
is_a: GO:0010753 ! positive regulation of cGMP-mediated signaling
is_a: GO:0141149 ! regulation of nitric oxide-cGMP mediated signal transduction
relationship: positively_regulates GO:0038060 ! nitric oxide-cGMP-mediated signaling

[Term]
id: GO:0141151
name: negative regulation of nitric oxide-cGMP mediated signal transduction
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction." [PMID:35931019]
is_a: GO:0010751 ! negative regulation of nitric oxide mediated signal transduction
is_a: GO:0010754 ! negative regulation of cGMP-mediated signaling
is_a: GO:0141149 ! regulation of nitric oxide-cGMP mediated signal transduction
relationship: negatively_regulates GO:0038060 ! nitric oxide-cGMP-mediated signaling

[Term]
id: GO:0141152
name: glycerol-3-phosphate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH." [RHEA:11092]
synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerol 1-phosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerol-3-phosphate dehydrogenase [NAD+] activity" EXACT []
synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "hydroglycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-alpha-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-alpha-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NADH-dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.8]
xref: EC:1.1.1.8
xref: KEGG_REACTION:R00842
xref: MetaCyc:1.1.1.8-RXN
xref: RHEA:11092
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0141153
name: glycerol-3-phosphate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "NADP+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADPH." [PMID:15557260, RHEA:11096]
synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" EXACT []
synonym: "glycerol-3-phosphate dehydrogenase [NADP+] activity" EXACT []
synonym: "L-glycerol-3-phosphate:NADP oxidoreductase activity" EXACT []
xref: KEGG_REACTION:R00844
xref: RHEA:11096
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0141154
name: symbiont-mediated suppression of host-directed shutoff of host translation
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20563710, PMID:21622569]
is_a: GO:0044414 ! symbiont-mediated suppression of host defenses

[Term]
id: GO:0141155
name: symbiont-mediated suppression of host translation elongation
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the translation elongation of host mRNA into protein, for example by directly inhibiting elongation factors. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:10657208, PMID:18281405, PMID:18448518]
is_a: GO:0039656 ! symbiont-mediated perturbation of host gene expression

[Term]
id: GO:0141156
name: cAMP/PKA signal transduction
namespace: biological_process
def: "An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell." [PMID:23209152]
synonym: "cAMP signaling" BROAD []
synonym: "cAMP/PKA signaling cassette" EXACT []
synonym: "PKA signaling" BROAD []
synonym: "protein kinase A signaling" BROAD []
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0141157
name: symbiont-mediated suppression of host exocytosis
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal execution of  host exocytosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17185412]
is_a: GO:1990215 ! symbiont-mediated perturbation of host vesicle-mediated transport

[Term]
id: GO:0141158
name: symbiont-mediated suppression of host phagosome maturation
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal maturation of host phagosomes. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21501366, PMID:30181274, PMID:30733336, PMID:30937925]
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:0141159
name: symbiont-mediated suppression of host phagosome acidification
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the normal acidification of host phagosomes. Mechanisms by which a symbiont prevents host phagosome acidification include the inhibitition of host V-ATPase, the proton pump that acidifies the phagosome, or disruption of the phagosome membrane by pore-forming toxin. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20333253, PMID:22087003, PMID:33505976]
is_a: GO:0052031 ! symbiont-mediated perturbation of host defense response

[Term]
id: GO:0141160
name: symbiont-mediated disruption of host phagosome
namespace: biological_process
def: "The process in which an organism effects a change that impairs the structure or function of host phagosomes." [PMID:15487949, PMID:21412437, PMID:30057173]
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0141161
name: regulation of cAMP/PKA signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cAMP/PKA signal transduction." [GOC:curators]
synonym: "regulation of cAMP/PKA signaling" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0141156 ! cAMP/PKA signal transduction

[Term]
id: GO:0141162
name: negative regulation of cAMP/PKA signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP/PKA signal transduction." [PMID:17376027]
synonym: "negative regulation of cAMP/PKA signaling" EXACT []
is_a: GO:0141161 ! regulation of cAMP/PKA signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0141156 ! cAMP/PKA signal transduction

[Term]
id: GO:0141163
name: positive regulation of cAMP/PKA signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cAMP/PKA signal transduction." [PMID:21585352]
synonym: "positive regulation of cAMP/PKA signaling" EXACT []
is_a: GO:0141161 ! regulation of cAMP/PKA signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0141156 ! cAMP/PKA signal transduction

[Term]
id: GO:0141164
name: mitochondrial protein quality control
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the mitochondrion, which are targeted for degradation." [PMID:38280230]
is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins

[Term]
id: GO:0141165
name: glucosinolate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a glucosinolate across a membrane." [PMID:37076627]
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0141166
name: chromosomal 5-methylcytosine DNA demethylation pathway
namespace: biological_process
def: "A process that chemically modifies 5-methylcytosine (5meC) to make it a substrate for the base excision repair pathway, which then restores the unmodified cytosine." [PMID:21862972, PMID:31546611, PMID:36478523]
comment: Note that this term describes the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child.
synonym: "epigenetic 5-methylcytosine DNA demethylation" RELATED []
synonym: "epigenetic 5-methylcytosine DNA demethylation pathway" RELATED []
synonym: "epigenetic DNA demethylation" RELATED []
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0141167
name: chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
namespace: biological_process
def: "An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC).  A DNA glycosylase (e. g. TDG) recognizes the  intermediate bases 5fC and 5caC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair." [PMID:21862972, PMID:29875631, PMID:36478523]
comment: Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child. A similar pathway may also convert chromosomal DNA N6-methyladenosine to adenosine but little evidence exists for this pathway.
synonym: "epigenetic 5-methylcytosine DNA demethylation, oxidation pathway" RELATED []
synonym: "epigenetic DNA demethylation, oxidation pathway" RELATED []
is_a: GO:0141137 ! positive regulation of gene expression, epigenetic
is_a: GO:0141166 ! chromosomal 5-methylcytosine DNA demethylation pathway

[Term]
id: GO:0141168
name: chromosomal 5-methylcytosine DNA demethylation, oxidative deamination pathway
namespace: biological_process
def: "An epigenetic cytosine DNA demethylation pathway that includes a deamination step to produce either a thymine (T), or a 5-hydroxymethyluracil (5hmU), if the 5meC had first been converted to 5hmC. A DNA glycosylase (e. g. TDG) recognizes the T mispaired with a G or the 5hmC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair." [PMID:21862972, PMID:29875631, PMID:36478523]
comment: Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child. A similar pathway may also convert chromosomal DNA N6-methyladenosine to adenosine but little evidence exists for this pathway. Current evidence indicates that this pathway in used for DNA repair, and not for epigenetic gene expression regulation.
synonym: "epigenetic 5-methylcytosine DNA demethylation, oxidative deamination pathway" RELATED []
synonym: "epigenetic DNA demethylation, oxidative deamination pathway" RELATED []
is_a: GO:0006281 ! DNA repair
is_a: GO:0141166 ! chromosomal 5-methylcytosine DNA demethylation pathway

[Term]
id: GO:0141169
name: chromosomal 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway
namespace: biological_process
def: "An epigenetic cytosine DNA demethylation pathway that involves a DNA glycosylase that directly excises 5-methylcytosine (5-meC) to initiate its replacement with unmethylated cytosine through base excision repair. This pathway is known to occur in plants. In addition to CG sites, plants also methylate cytosines within CHH and CNG sequences." [PMID:21862972, PMID:31546611, PMID:36478523]
comment: Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child.
synonym: "epigenetic 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway" RELATED []
is_a: GO:0141166 ! chromosomal 5-methylcytosine DNA demethylation pathway

[Term]
id: GO:0141170
name: positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway." [PMID:36478523]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0141169 ! chromosomal 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway

[Term]
id: GO:0141171
name: symbiont-mediated perturbation of host membrane
namespace: biological_process
def: "The process in which a symbiont effects a change that impairs the structure or function of a host membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:14688136, PMID:17043230, PMID:28855258]
synonym: "symbiont-mediated disruption of host membrane" NARROW []
is_a: GO:0052008 ! symbiont-mediated disruption of host cellular anatomical structure

[Term]
id: GO:0141173
name: symbiont-mediated suppression of host pro-inflammatory cytokine signaling
namespace: biological_process
def: "A process by which a symbiont inhibits or disrupts pro-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway. Pro-inflammatory cytokines include: IL-1, IL-12, IL-18, TNF, IFN-gamma, and GM-CSF. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20008527, PMID:24508400, PMID:32117813]
synonym: "negative regulation by symbiont of host pro-inflammatory cytokine production" EXACT []
synonym: "suppression by symbiont of host pro-inflammatory cytokine production" EXACT []
synonym: "suppression by symbiont of host pro-inflammatory cytokine secretion" RELATED []
synonym: "symbiont-mediated degradation of host pro-inflammatory cytokine" NARROW []
synonym: "symbiont-mediated sequestering of host pro-inflammatory cytokine" RELATED []
synonym: "symbiont-mediated suppression of host pro-inflammatory cytokine production" RELATED []
is_a: GO:0075109 ! symbiont-mediated perturbation of host receptor-mediated signal transduction

[Term]
id: GO:0141174
name: symbiont-mediated suppression of host anti-inflammatory cytokine signaling
namespace: biological_process
def: "A process by which a symbiont inhibits or disrupts anti-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway.  Anti-inflammatory cytokines include: interleukin (IL)-1, IL-4, IL-6, IL-10, IL-11, and IL-13. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:19168731, PMID:29720526, PMID:32754056]
synonym: "negative regulation by symbiont of host anti-inflammatory cytokine production" EXACT []
synonym: "suppression by symbiont of host anti-inflammatory cytokine production" EXACT []
synonym: "suppression by symbiont of host anti-inflammatory cytokine secretion" RELATED []
synonym: "symbiont-mediated degradation of host anti-inflammatory cytokine" NARROW []
synonym: "symbiont-mediated sequestering of host anti-inflammatory cytokine" RELATED []
synonym: "symbiont-mediated suppression of host anti-inflammatory cytokine production" RELATED []
is_a: GO:0075109 ! symbiont-mediated perturbation of host receptor-mediated signal transduction

[Term]
id: GO:0141175
name: receptor clustering activity
namespace: molecular_function
def: "A protein-protein adaptor that acts as a platform for receptor clustering, often serving to amplify the sensitivity of a signaling response." [PMID:19747931, PMID:21453460, PMID:33597156]
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0141176
name: gene silencing by piRNA-directed DNA methylation
namespace: biological_process
def: "A small RNA-based gene silencing process in which Piwi-associated RNAs (piRNAs) guide de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription." [PMID:32674113, PMID:38359823]
is_a: GO:0006346 ! DNA methylation-dependent constitutive heterochromatin formation
is_a: GO:0140966 ! piRNA-mediated heterochromatin formation

[Term]
id: GO:0141177
name: symbiont-mediated evasion of recognition by host innate immune effector
namespace: biological_process
def: "A process by which a symbiont mitigates the effects of recognition by a host innate immune effector. Effectors have a direct activity against a symbiont and include complement, antimicrobial peptides, and bacterial restriction enzymes. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:19208801, PMID:33330873]
synonym: "evasion of symbiont recognition by host innate immune effector" EXACT []
is_a: GO:0141043 ! symbiont-mediated evasion of host innate immune response

[Term]
id: GO:0141178
name: symbiont-mediated evasion of recognition by host complement
namespace: biological_process
def: "A process by which a symbiont avoids the effects of recognition by host  complement by altering molecules on the symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22825444, PMID:25537831, PMID:34887398]
synonym: "symbiont-mediated evasion of host complement" EXACT []
is_a: GO:0141177 ! symbiont-mediated evasion of recognition by host innate immune effector

[Term]
id: GO:0141179
name: symbiont-mediated evasion of recognition by host antimicrobial peptide
namespace: biological_process
def: "A process by which a symbiont avoids the effects of recognition by a host  antimicrobial peptide by altering molecules on the symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11401964, PMID:22966934, PMID:25537831]
is_a: GO:0141177 ! symbiont-mediated evasion of recognition by host innate immune effector

[Term]
id: GO:0141180
name: dsDNA-RNA triple helix-forming chromatin adaptor activity
namespace: molecular_function
def: "A chromatin-protein adaptor activity that bridges dsDNA and chromatin proteins to bring regions of a chromosome in proximity. The DNA:DNA:RNA triple-helical structure is formed non-Watson-Crick base-pairing." [PMID:35412350]
is_a: GO:0140463 ! chromatin-protein adaptor activity
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0141184
name: symbiont-mediated activation of host anti-inflammatory cytokine signaling
namespace: biological_process
def: "A process in which a symbiont subverts an anti-inflammatory cytokine signaling pathway in the host organism by initiating, promoting, or enhancing its activation." [PMID:23284742, PMID:27437422, PMID:29924996]
is_a: GO:0052028 ! symbiont-mediated activation of host signal transduction pathway

[Term]
id: GO:0141185
name: UFM1-modified protein reader activity
namespace: molecular_function
def: "A molecular adaptor recognizes and binds a target protein containing a UFM1 modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way." [PMID:32537488, PMID:36848233, PMID:38383785, PMID:38383789]
synonym: "UFM1 modified protein reader activity" EXACT []
synonym: "UFM1-dependent protein binding" EXACT []
is_a: GO:0140035 ! ubiquitin-like protein reader activity

[Term]
id: GO:0141187
name: nucleic acid biosynthetic process
namespace: biological_process
def: "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0090304 ! nucleic acid metabolic process

[Term]
id: GO:0141188
name: nucleic acid catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0090304 ! nucleic acid metabolic process

[Term]
id: GO:0141189
name: obsolete G protein mediated opsin signaling pathway
namespace: biological_process
def: "OBSOLETE. A phospholipase C-activating receptor G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and ending with the light signal being trasmitted through the synapses. Opsins are G-protein coupled receptors which bind light-sensitive chromophores." [PMID:19720651, PMID:36272560]
comment: This term was obsoleted because it was created by mistake; it represents the same process as G protein-mediated opsin signaling pathway ; GO:0030265.
synonym: "G protein-mediated opsin signaling pathway" EXACT []
synonym: "phospholipase C-activating G protein-mediated phototransduction signaling pathway" EXACT []
synonym: "phospholipase C-activating phototransduction signaling pathway" EXACT []
synonym: "phospholipase C-activating phototransduction-mediated G-protein coupled receptor signaling pathway" EXACT []
synonym: "phototransduction-mediated G protein signaling, coupled to IP3 second messenger" EXACT []
synonym: "phototransduction-mediated G protein signalling, coupled to IP3 second messenger" EXACT []
synonym: "phototransduction-mediated G-protein signaling, coupled to IP3 second messenger" EXACT [GOC:signaling]
synonym: "phototransduction-mediated G-protein signalling, coupled to IP3 second messenger" EXACT []
synonym: "PLC-activating phototransduction-mediated signaling pathway" EXACT []
is_obsolete: true
replaced_by: GO:0030265

[Term]
id: GO:0141190
name: transducin-mediated opsin signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway that starts with an opsin molecule being activated by a photon. Opsins include rhodopsin and others visual receptors bind heterotrimeric transducin G proteins upon activation. Activated transducin alpha-subunit activates cGMP phosphodiesterase, which breaks down cGMP. The decrease in cGMP concentration leads to closure of cGMP-gated (CNG) channels, blockage of Na+ influx, and hyperpolarization of photoreceptor plasma membrane, leading to transmission of signal through synapses. The signal is terminated by phosphorylation of the C-terminal tail of rhodopsin by rhodopsin kinase to allow arrestin to bind and block G protein binding. Typical examples are rhabdomeric photoreceptors in the eyes of deuterostomes." [PMID:19720651, PMID:36272560, PMID:36499010, PMID:37159291]
synonym: "cGMP-mediated opsin signaling pathway" EXACT []
synonym: "cGMP-mediated rhodopsin signaling pathway" NARROW []
synonym: "ciliary opsin-mediated signaling pathway" EXACT []
synonym: "cyclic-GMP-mediated opsin signaling pathway" EXACT []
synonym: "cyclic-nucleotide-mediated opsin signaling pathway" EXACT []
synonym: "Gt-mediated opsin signaling pathway" EXACT []
is_a: GO:0016056 ! G protein-coupled opsin signaling pathway

[Term]
id: GO:0141191
name: negative regulation of HRI-mediated signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of HRI-mediated signaling." [PMID:38297121]
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0141192
name: ATP:ATP adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + H+ = diphosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [PMID:16884494, PMID:19710017, PMID:27398309, RHEA:34935]
synonym: "adenine triphosphate adenylyltransferase activity" RELATED []
xref: Reactome:R-HSA-9825790 "p-S207 KARS1 dimer synthesizes A(5')p4(5')A"
xref: RHEA:34935
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0141193
name: nuclear receptor-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a signaling molecule binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:25614732]
synonym: "nuclear receptor signaling pathway" EXACT []
is_a: GO:0030522 ! intracellular receptor signaling pathway

[Term]
id: GO:0141194
name: siRNA-mediated heterochromatin formation
namespace: biological_process
def: "The formation of heterochromatin into a heterochromatin domain by a process mediated by a small interfering siRNA." [GOC:ha, GOC:pg]
is_a: GO:0031048 ! regulatory ncRNA-mediated heterochromatin formation

[Term]
id: GO:0141195
name: obsolete piRNA-mediated facultative heterochromatin formation
namespace: biological_process
def: "OBSOLETE. The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a Piwi-associated RNA (piRNA)." [PMID:26494711]
comment: This term was obsoleted because the evidence is too weak to implicate piRNAs in facultative heterochromatin formation.
is_obsolete: true
consider: GO:0140966

[Term]
id: GO:0141196
name: transposable element silencing by piRNA-mediated DNA methylation
namespace: biological_process
def: "A transposable element silencing mechanism mediated by Piwi-associated RNA (piRNA)-directed DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription." [PMID:32674113]
synonym: "retrotransposon silencing by piRNA-directed DNA methylation" NARROW []
synonym: "transposable element silencing by piRNA-directed DNA methylation" EXACT []
is_a: GO:0141005 ! transposable element silencing by heterochromatin formation
is_a: GO:0141176 ! gene silencing by piRNA-directed DNA methylation

[Term]
id: GO:0141197
name: 4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin)
namespace: molecular_function
def: "Catalysis of the reaction: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]." [RHEA:43604]
synonym: "(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity" BROAD [EC:1.17.7.3]
synonym: "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity" BROAD [EC:1.17.7.3]
xref: EC:1.17.7.3
xref: KEGG_REACTION:R10859
xref: MetaCyc:RXN-15878
xref: RHEA:43604
is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

[Term]
id: GO:0141198
name: protein branched polyubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at various positions of the ubiquitin monomers, forming branched linkages, such as K11/K48- or K11/K63-linked chains." [PMID:29033132, PMID:29378950, PMID:31998699, PMID:37325469]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0141199
name: GDP-mannose biosynthetic process from glucose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from glucose." [PMID:21273394, PMID:9287314]
xref: MetaCyc:PWY-5659
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0009298 ! GDP-mannose biosynthetic process

[Term]
id: GO:0141200
name: UTP thiamine diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + thiamine = UMP + thiamine diphosphate." [PMID:38547260, RHEA:79423]
xref: RHEA:79423
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0141201
name: pyroptotic cell death
namespace: biological_process
def: "A inflammatory cell death process associated with the generation of pyrogenic mediators that result from the activation of gasdermins." [PMID:18846107, PMID:21760595, PMID:33883744]
synonym: "pyroptosis" BROAD []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0070269 ! pyroptotic inflammatory response

[Term]
id: GO:0141203
name: symbiont-mediated suppression of host complement activation by activation of host proteases
namespace: biological_process
def: "A process by which a symbiont prevents host complement activation by recruiting host proteases, destroying the complement before it has its effect on the symbiont." [PMID:15792635, PMID:26945067, PMID:34305859]
synonym: "symbiont-mediated suppression of host complement activation by recruitment of host proteases" NARROW []
is_a: GO:0042784 ! symbiont-mediated suppression of host complement activation

[Term]
id: GO:0141204
name: dipeptide transmembrane transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of dipeptide from the lysosomal lumen across the lysosomal membrane and into the cytosol." [PMID:38507452]
synonym: "dipeptide export from lysosomal lumen" EXACT []
synonym: "dipeptide export from lysosome" EXACT []
synonym: "transmembrane dipeptide transport from lysosomal lumen to cytosol" EXACT []
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0015833 ! peptide transport
is_a: GO:0034486 ! vacuolar transmembrane transport

[Term]
id: GO:0141207
name: peptide lactyltransferase (ATP-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: lactate + ATP + L-lysyl-[protein] = N(6)-lactoyl-L-lysyl-[protein]+ AMP + diphosphate. Can also act on free lactate." [PMID:38512451, PMID:38653238, RHEA:80271]
synonym: "peptide lactyltransferase (ATP dependent) activity" EXACT []
synonym: "peptide lactyltransferase activity" BROAD []
xref: RHEA:80271
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0141208
name: NAD-dependent protein lysine delactylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD." [PMID:38512451, RHEA:80287]
synonym: "protein lysine delactylase activity" BROAD []
xref: RHEA:80287
is_a: GO:0034979 ! NAD-dependent protein lysine deacetylase activity

[Term]
id: GO:0141209
name: oxysterol receptor signaling pathway
namespace: biological_process
def: "A nuclear receptor-mediated signaling pathway initiated by an oxysterol binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:37541371, PMID:9794827]
synonym: "intracellular oxysterol receptor signaling pathway" EXACT []
synonym: "nuclear receptor-mediated oxysterol signaling pathway" EXACT []
is_a: GO:0030518 ! nuclear receptor-mediated steroid hormone signaling pathway

[Term]
id: GO:0141212
name: phospholipase C/protein kinase C signal transduction
namespace: biological_process
def: "An intracellular signaling cassette that starts with activation of phospholipase C (PLC) activity and ends with the activation of protein kinase C (PKC). PLC produces inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. This cassette is often part of the phospholipase C-activating G protein-coupled receptor signaling pathway." [PMID:26605346]
synonym: "PLC/PKC signaling" EXACT []
synonym: "PLC/PKC/PKD signaling" EXACT []
is_a: GO:0141124 ! intracellular signaling cassette

[Term]
id: GO:0141213
name: symbiont-mediated generation of symbiont replication vacuole
namespace: biological_process
def: "A process in which a symbiont alters or subverts vacuole organization in its host organism to form a protected environment in which it can replicate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21822290, PMID:23186105, PMID:30893609]
is_a: GO:0044075 ! symbiont-mediated perturbation of host vacuole organization

[Term]
id: GO:0141214
name: positive regulation of phospholipase C/protein kinase C signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipase C/protein kinase C signal transduction." [PMID:24008408, PMID:32255775]
synonym: "positive regulation of PLC/PKC signal transduction" EXACT []
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0141212 ! phospholipase C/protein kinase C signal transduction

[Term]
id: GO:0141215
name: N-acetyltaurine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyltaurine + H2O = acetate + taurine." [PMID:39112712]
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0141217
name: RNA glycosylation
namespace: biological_process
def: "The posttranscriptional addition of a carbohydrate or carbohydrate derivative unit to residues in an RNA molecule." [PMID:34004145, PMID:39173631]
synonym: "glycoRNA biosynthesis" EXACT []
is_a: GO:0006396 ! RNA processing
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0141218
name: NAD-dependent protein lysine deacylase activity
namespace: molecular_function
def: "Removal of an acyl group from a protein via transfer of the acyl group to NAD+, producing nicotinamide." [PMID:35044827]
synonym: "protein lysine deacylase activity" BROAD []
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0141221
name: histone deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]." [PMID:24691964, PMID:28450737]
comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
synonym: "histone deacetylase activity" BROAD []
synonym: "histone deacetylase activity, NAD-independent" EXACT []
xref: EC:3.5.1.98
xref: MetaCyc:3.5.1.98-RXN
is_a: GO:0004407 ! histone deacetylase activity
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0141222
name: histone H3K4 deacetylase activity, NAD-dependent
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K4 to NAD, producing nicotinamide." [PMID:20299449, PMID:23771057]
is_a: GO:0017136 ! histone deacetylase activity, NAD-dependent
is_a: GO:0141050 ! histone H3K deacetylase activity

[Term]
id: GO:0141223
name: cysteine synthase activity, acting on O-succinyl-L-serine
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + O-succinyl-L-serine = L-cysteine + succinate." [RHEA:53816]
synonym: "cysteine synthase activity" BROAD []
xref: RHEA:53816
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0150001
name: primary dendrite
namespace: cellular_component
def: "A dendrite emerging from the cell body (the soma) of a neuron." [GOC:aruk, GOC:bc]
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0150002
name: distal dendrite
namespace: cellular_component
def: "The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:20629984]
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0150003
name: regulation of spontaneous synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission." [GOC:aruk, GOC:bc, PMID:15457210]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0098814 ! spontaneous synaptic transmission

[Term]
id: GO:0150004
name: dendritic spine origin
namespace: cellular_component
def: "The part of the dendritic spine neck where the spine arises from the dendritic shaft." [GOC:aruk, GOC:bc, PMID:9030614]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0044326 ! dendritic spine neck

[Term]
id: GO:0150005
name: enzyme activator complex
namespace: cellular_component
def: "A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active." [GOC:bhm, PMID:16244137, PMID:28710280]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0150006
name: urease activator complex
namespace: cellular_component
def: "A protein complex required for the activation of urease. Activator subunits dissociate before urease has catalytic function." [GOC:bhm, PMID:16244137, PMID:28710280]
is_a: GO:0150005 ! enzyme activator complex

[Term]
id: GO:0150007
name: clathrin-dependent synaptic vesicle endocytosis
namespace: biological_process
def: "Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]
is_a: GO:0046907 ! intracellular transport
is_a: GO:0048488 ! synaptic vesicle endocytosis
is_a: GO:0072583 ! clathrin-dependent endocytosis
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome

[Term]
id: GO:0150008
name: bulk synaptic vesicle endocytosis
namespace: biological_process
def: "Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse." [GOC:aruk, GOC:bc, GOC:ha, PMID:18250322, PMID:18579735, PMID:19266323, PMID:26430111, PMID:28391090]
synonym: "activity-dependent bulk endocytosis" EXACT []
synonym: "activity-dependent bulk synaptic vesicle endocytosis" EXACT []
synonym: "ADBE" EXACT []
synonym: "bulk endocytosis" EXACT []
is_a: GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0150011
name: regulation of neuron projection arborization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044]
synonym: "regulation of neurite arborization" EXACT []
synonym: "regulation of neurite branching" EXACT []
synonym: "regulation of neuron projection branching" EXACT []
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0031344 ! regulation of cell projection organization
relationship: regulates GO:0140058 ! neuron projection arborization

[Term]
id: GO:0150012
name: positive regulation of neuron projection arborization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044]
synonym: "positive regulation of neurite arborization" EXACT []
synonym: "positive regulation of neurite branching" EXACT []
synonym: "positive regulation of neuron projection branching" EXACT []
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0150011 ! regulation of neuron projection arborization
relationship: positively_regulates GO:0140058 ! neuron projection arborization

[Term]
id: GO:0150013
name: negative regulation of neuron projection arborization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044]
synonym: "negative regulation of neurite arborization" EXACT []
synonym: "negative regulation of neurite branching" EXACT []
synonym: "negative regulation of neuron projection branching" EXACT []
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0150011 ! regulation of neuron projection arborization
relationship: negatively_regulates GO:0140058 ! neuron projection arborization

[Term]
id: GO:0150014
name: apical distal dendrite
namespace: cellular_component
def: "Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma)." [GO:bc, GOC:aruk, PMID:1720142, PMID:20629984, PMID:9214543]
is_a: GO:0097440 ! apical dendrite
is_a: GO:0150002 ! distal dendrite

[Term]
id: GO:0150015
name: apical proximal dendrite
namespace: cellular_component
def: "The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma)." [GOC:aruk, GOC:bc, PMID:16899232, PMID:1720142, PMID:9214543]
is_a: GO:0097440 ! apical dendrite
is_a: GO:1990635 ! proximal dendrite

[Term]
id: GO:0150016
name: basal distal dendrite
namespace: cellular_component
def: "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is farthest away from the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:17046728, PMID:1720142, PMID:20629984, PMID:22683681, PMID:9214543]
is_a: GO:0097441 ! basal dendrite
is_a: GO:0150002 ! distal dendrite

[Term]
id: GO:0150017
name: basal proximal dendrite
namespace: cellular_component
def: "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma)." [GOC:aruk, GOC:bc, PMID:16899232, PMID:17046728, PMID:1720142, PMID:22683681, PMID:9214543]
is_a: GO:0097441 ! basal dendrite
is_a: GO:1990635 ! proximal dendrite

[Term]
id: GO:0150018
name: basal dendrite development
namespace: biological_process
def: "The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, PMID:22683681]
is_a: GO:0016358 ! dendrite development

[Term]
id: GO:0150019
name: basal dendrite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a basal dendrite are generated and organized." [GOC:aruk, GOC:bc, PMID:22683681]
is_a: GO:0048813 ! dendrite morphogenesis
relationship: part_of GO:0150018 ! basal dendrite development

[Term]
id: GO:0150020
name: basal dendrite arborization
namespace: biological_process
def: "The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:22683681]
is_a: GO:0140059 ! dendrite arborization
is_a: GO:0150019 ! basal dendrite morphogenesis

[Term]
id: GO:0150021
name: apical dendrite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an apical dendrite are generated and organized." [GOC:aruk, GOC:bc, PMID:22683681]
is_a: GO:0048813 ! dendrite morphogenesis
relationship: part_of GO:0150022 ! apical dendrite development

[Term]
id: GO:0150022
name: apical dendrite development
namespace: biological_process
def: "The process whose specific outcome is the progression of an apical dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, PMID:22683681]
is_a: GO:0016358 ! dendrite development

[Term]
id: GO:0150023
name: apical dendrite arborization
namespace: biological_process
def: "The process in which the anatomical structures of a dendritic tree are generated on the apical neuron side and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:22683681]
is_a: GO:0140059 ! dendrite arborization
is_a: GO:0150021 ! apical dendrite morphogenesis

[Term]
id: GO:0150024
name: oxidised low-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:aruk, GOC:bc, PMID:27607416]
synonym: "ox-LDL particle clearance" EXACT []
synonym: "oxidised LDL particle clearance" EXACT []
synonym: "oxidized LDL particle clearance" EXACT []
synonym: "oxidized low-density lipoprotein particle clearance" EXACT []
synonym: "oxLDL particle clearance" EXACT []
is_a: GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0150025
name: oxidised low-density lipoprotein particle receptor activity
namespace: molecular_function
def: "Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis." [GOC:aruk, GOC:bc, PMID:27607416]
synonym: "ox-LDL particle receptor activity" EXACT []
synonym: "ox-LDL receptor activity" RELATED []
synonym: "oxidised LDL particle receptor activity" EXACT []
synonym: "oxidised LDL receptor activity" RELATED []
synonym: "oxidised low-density lipoprotein receptor activity" RELATED []
synonym: "oxidized LDL particle receptor activity" EXACT []
synonym: "oxidized LDL receptor activity" RELATED []
synonym: "oxidized low-density lipoprotein particle receptor activity" EXACT []
synonym: "oxidized low-density lipoprotein receptor activity" RELATED []
synonym: "oxLDL particle receptor activity" EXACT []
synonym: "oxLDL receptor activity" RELATED []
is_a: GO:0030228 ! lipoprotein particle receptor activity

[Term]
id: GO:0150031
name: regulation of protein localization to lysosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0061462 ! protein localization to lysosome

[Term]
id: GO:0150032
name: positive regulation of protein localization to lysosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc]
is_a: GO:0150031 ! regulation of protein localization to lysosome
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:0061462 ! protein localization to lysosome

[Term]
id: GO:0150033
name: negative regulation of protein localization to lysosome
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806]
is_a: GO:0150031 ! regulation of protein localization to lysosome
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:0061462 ! protein localization to lysosome

[Term]
id: GO:0150034
name: distal axon
namespace: cellular_component
def: "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468]
synonym: "distal part of axon" EXACT []
synonym: "distal part of the axon" EXACT [PMID:17202468]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0150035
name: regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:19448629]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0099183 ! trans-synaptic signaling by BDNF, modulating synaptic transmission

[Term]
id: GO:0150036
name: regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:27296803]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0099553 ! trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

[Term]
id: GO:0150037
name: regulation of calcium-dependent activation of synaptic vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion." [GOC:aruk, GOC:bc, PMID:27052163]
subset: goslim_synapse
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane
relationship: regulates GO:0099502 ! calcium-dependent activation of synaptic vesicle fusion

[Term]
id: GO:0150038
name: postsynaptic dense core vesicle exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels." [GOC:aruk, GOC:bc, PMID:19448629]
subset: goslim_synapse
is_a: GO:0099003 ! vesicle-mediated transport in synapse
is_a: GO:0099011 ! neuronal dense core vesicle exocytosis

[Term]
id: GO:0150043
name: structural constituent of synapse-associated extracellular matrix
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:aruk, GOC:bc, PMID:17189701]
subset: goslim_synapse
synonym: "extra-synaptic extracellular matrix structural constituent" EXACT []
synonym: "structural constituent of extra-synaptic extracellular matrix" EXACT []
synonym: "synapse-associated extracellular matrix structural constituent" EXACT []
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0150044
name: regulation of postsynaptic dense core vesicle exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis." [GOC:aruk, GOC:bc, PMID:19448629]
subset: goslim_synapse
is_a: GO:1905413 ! regulation of dense core granule exocytosis
relationship: regulates GO:0150038 ! postsynaptic dense core vesicle exocytosis

[Term]
id: GO:0150045
name: regulation of synaptic signaling by nitric oxide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide." [GOC:aruk, GOC:bc, PMID:26311509]
subset: goslim_synapse
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
relationship: regulates GO:0099163 ! synaptic signaling by nitric oxide

[Term]
id: GO:0150047
name: G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential." [GOC:aruk, GOC:bc, PMID:11498050]
subset: goslim_synapse
synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential" EXACT []
is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity

[Term]
id: GO:0150048
name: cerebellar granule cell to Purkinje cell synapse
namespace: cellular_component
def: "A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum." [GOC:aruk, GOC:bc, PMID:12427822]
subset: goslim_synapse
synonym: "cerebellar parallel fiber to Purkinje cell synapse" EXACT []
is_a: GO:0098985 ! asymmetric, glutamatergic, excitatory synapse

[Term]
id: GO:0150050
name: postsynaptic septin cytoskeleton
namespace: cellular_component
def: "The portion of the septin cytoskeleton contained within the postsynapse." [GOC:aruk, GOC:bc, PMID:28065648]
subset: goslim_synapse
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0099571 ! postsynaptic cytoskeleton

[Term]
id: GO:0150051
name: postsynaptic Golgi apparatus
namespace: cellular_component
def: "The network of the Golgi apparatus structures located within the postsynapse." [GOC:aruk, GOC:bc, PMID:23838184]
subset: goslim_synapse
synonym: "Golgi outpost" RELATED [GOC:aruk, GOC:bc, PMID:21215635]
is_a: GO:0005794 ! Golgi apparatus
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0150052
name: regulation of postsynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854]
subset: goslim_synapse
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099175 ! regulation of postsynapse organization
relationship: regulates GO:0099068 ! postsynapse assembly

[Term]
id: GO:0150053
name: cerebellar climbing fiber to Purkinje cell synapse
namespace: cellular_component
def: "A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata." [GOC:aruk, GOC:bc, PMID:19597563, PMID:23811844, PMID:5044254]
subset: goslim_synapse
synonym: "cerebellar climbing fibre to Purkinje cell synapse" EXACT []
is_a: GO:0098985 ! asymmetric, glutamatergic, excitatory synapse

[Term]
id: GO:0150054
name: regulation of postsynaptic neurotransmitter receptor diffusion trapping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping." [GOC:aruk, GOC:bc, PMID:20935643]
subset: goslim_synapse
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:1902683 ! regulation of receptor localization to synapse
relationship: regulates GO:0098970 ! postsynaptic neurotransmitter receptor diffusion trapping

[Term]
id: GO:0150056
name: amylin receptor complex 1
namespace: cellular_component
def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019]
synonym: "AMY1 complex" EXACT []
is_a: GO:1903440 ! amylin receptor complex

[Term]
id: GO:0150057
name: amylin receptor complex 2
namespace: cellular_component
def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019]
synonym: "AMY2 complex" EXACT []
is_a: GO:1903440 ! amylin receptor complex

[Term]
id: GO:0150058
name: amylin receptor complex 3
namespace: cellular_component
def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signaling pathways." [GOC:aruk, GOC:bc, PMID:22500019]
synonym: "AMY3 complex" EXACT []
is_a: GO:1903440 ! amylin receptor complex

[Term]
id: GO:0150059
name: amylin receptor 1 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 1 (AMY1), a G protein-coupled receptor complex, on the surface of the target cell. Other ligands that have been shown to initiate the AMY1 signaling pathway include the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019]
synonym: "AMY1 signaling pathway" EXACT []
is_a: GO:0097647 ! amylin receptor signaling pathway

[Term]
id: GO:0150060
name: amylin receptor 2 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 2 (AMY2), a G protein-coupled receptor complex, on the surface of the target cell. The AMY2 signaling pathway can also be initiated by adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019]
synonym: "AMY2 signaling pathway" EXACT []
is_a: GO:0097647 ! amylin receptor signaling pathway

[Term]
id: GO:0150061
name: amylin receptor 3 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos." [GOC:aruk, GOC:bc, PMID:22500019]
synonym: "AMY3 signaling pathway" EXACT []
is_a: GO:0097647 ! amylin receptor signaling pathway

[Term]
id: GO:0150062
name: complement-mediated synapse pruning
namespace: biological_process
def: "Synaptic pruning mediated by complement system signaling." [GOC:aruk, GOC:bc, PMID:18083105, PMID:22632727, PMID:29844190]
synonym: "complement-dependent synapse pruning" EXACT []
synonym: "synapse clearance" BROAD []
synonym: "synapse disassembly" BROAD []
synonym: "synapse elimination" BROAD []
synonym: "synapse removal" BROAD []
is_a: GO:0098883 ! synapse pruning

[Term]
id: GO:0150063
name: visual system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727]
synonym: "optic pathway development" RELATED []
synonym: "visual pathway development" RELATED []
is_a: GO:0048880 ! sensory system development

[Term]
id: GO:0150064
name: vertebrate eye-specific patterning
namespace: biological_process
def: "Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus." [GOC:aruk, GOC:bc, PMID:16025107, PMID:22632727, PMID:29322522]
synonym: "binocular vision development" RELATED []
synonym: "eye-specific patterning" BROAD []
synonym: "eye-specific segregation" BROAD []
synonym: "vertebrate eye-specific segregation" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0150063 ! visual system development

[Term]
id: GO:0150065
name: regulation of deacetylase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097]
subset: gocheck_obsoletion_candidate
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0150066
name: negative regulation of deacetylase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097]
subset: gocheck_obsoletion_candidate
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0150065 ! regulation of deacetylase activity

[Term]
id: GO:0150067
name: regulation of tubulin deacetylase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097]
subset: gocheck_obsoletion_candidate
is_a: GO:0051336 ! regulation of hydrolase activity
is_a: GO:0090043 ! regulation of tubulin deacetylation
is_a: GO:0150065 ! regulation of deacetylase activity

[Term]
id: GO:0150068
name: obsolete positive regulation of tubulin deacetylase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0150069
name: obsolete negative regulation of tubulin deacetylase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0150070
name: regulation of arginase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc, PMID:26670206]
subset: gocheck_obsoletion_candidate
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0150071
name: obsolete negative regulation of arginase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0150072
name: positive regulation of arginase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc, PMID:26670206]
subset: gocheck_obsoletion_candidate
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0150070 ! regulation of arginase activity

[Term]
id: GO:0150073
name: regulation of protein-glutamine gamma-glutamyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc, PMID:26670206]
subset: gocheck_obsoletion_candidate
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0150074
name: positive regulation of protein-glutamine gamma-glutamyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc, PMID:26670206]
subset: gocheck_obsoletion_candidate
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:0150073 ! regulation of protein-glutamine gamma-glutamyltransferase activity

[Term]
id: GO:0150075
name: obsolete negative regulation of protein-glutamine gamma-glutamyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0150076
name: neuroinflammatory response
namespace: biological_process
def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
synonym: "nerve tissue inflammatory response" EXACT []
synonym: "nervous tissue inflammatory response" EXACT []
synonym: "neural tissue inflammatory response" EXACT []
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0150077
name: regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
is_a: GO:0050727 ! regulation of inflammatory response
relationship: regulates GO:0150076 ! neuroinflammatory response

[Term]
id: GO:0150078
name: positive regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc]
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0150077 ! regulation of neuroinflammatory response
relationship: positively_regulates GO:0150076 ! neuroinflammatory response

[Term]
id: GO:0150079
name: negative regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423]
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0150077 ! regulation of neuroinflammatory response
relationship: negatively_regulates GO:0150076 ! neuroinflammatory response

[Term]
id: GO:0150086
name: multiple synapse bouton
namespace: cellular_component
def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding either from a single dendrite or from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344]
synonym: "MSB" EXACT []
synonym: "multi-synapse" RELATED []
synonym: "multi-synapse bouton" EXACT []
synonym: "multi-synaptic bouton" EXACT []
synonym: "multiple spine synapse bouton" EXACT []
synonym: "multiple synapse" RELATED []
synonym: "multiple-synapse bouton" EXACT []
synonym: "multisynapse" RELATED []
synonym: "multisynapse bouton" EXACT []
synonym: "multisynaptic bouton" EXACT []
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:0150087
name: multiple synapse bouton, contacting single dendrite
namespace: cellular_component
def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding from the same dendrite." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234]
synonym: "MSB1" EXACT [PMID:24487234]
synonym: "type 1 multi-synapse bouton" EXACT [PMID:24487234]
synonym: "type 1 multi-synaptic bouton" EXACT [PMID:24487234]
synonym: "type 1 multiple spine synapse bouton" EXACT [PMID:24487234]
synonym: "type 1 multiple-synapse bouton" EXACT [PMID:24487234]
synonym: "type 1 multisynapse bouton" EXACT [PMID:24487234]
synonym: "type 1 multisynaptic bouton" EXACT [PMID:24487234]
is_a: GO:0150086 ! multiple synapse bouton

[Term]
id: GO:0150088
name: multiple synapse bouton, contacting multiple dendrites
namespace: cellular_component
def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344]
synonym: "MSB2" EXACT [PMID:24487234]
synonym: "type 2 multi-synapse bouton" EXACT [PMID:24487234]
synonym: "type 2 multi-synaptic bouton" EXACT [PMID:24487234]
synonym: "type 2 multiple spine synapse bouton" EXACT [PMID:24487234]
synonym: "type 2 multiple-synapse bouton" EXACT [PMID:24487234]
synonym: "type 2 multisynapse bouton" EXACT [PMID:24487234]
synonym: "type 2 multisynaptic bouton" EXACT [PMID:24487234]
is_a: GO:0150086 ! multiple synapse bouton

[Term]
id: GO:0150089
name: multiple spine synapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and one or more dendritic spines." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344]
synonym: "multi-synapse organisation" BROAD []
synonym: "multi-synapse organization" BROAD []
synonym: "multi-synaptic organisation" BROAD []
synonym: "multi-synaptic organization" BROAD []
synonym: "multiple spine synapse organisation" EXACT []
synonym: "multisynapse organisation" BROAD []
synonym: "multisynapse organization" BROAD []
synonym: "multisynaptic organisation" BROAD []
synonym: "multisynaptic organization" BROAD []
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0150090
name: multiple spine synapse organization, single dendrite
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234]
is_a: GO:0150089 ! multiple spine synapse organization

[Term]
id: GO:0150091
name: multiple spine synapse organization, multiple dendrites
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344]
is_a: GO:0150089 ! multiple spine synapse organization

[Term]
id: GO:0150092
name: regulation of synaptic scaling
namespace: biological_process
def: "A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell." [GOC:aruk, GOC:bc, PMID:14630218, PMID:14735113, PMID:16547515]
synonym: "homeostatic synaptic scaling" RELATED [PMID:16547515]
synonym: "regulation of homeostatic synaptic scaling" RELATED []
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0150093
name: amyloid-beta clearance by transcytosis
namespace: biological_process
def: "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:26005850]
is_a: GO:0045056 ! transcytosis
is_a: GO:0097242 ! amyloid-beta clearance

[Term]
id: GO:0150094
name: amyloid-beta clearance by cellular catabolic process
namespace: biological_process
def: "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation." [GOC:aruk, GOC:bc, PMID:18289866]
synonym: "amyloid-beta clearance by phagocytosis" NARROW []
is_a: GO:0009056 ! catabolic process
is_a: GO:0050435 ! amyloid-beta metabolic process
is_a: GO:0097242 ! amyloid-beta clearance

[Term]
id: GO:0150098
name: glial cell-neuron signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440]
synonym: "glia-neuron signaling" EXACT []
synonym: "glia-neuron signalling" EXACT []
synonym: "glia-neurone signaling" EXACT []
synonym: "glia-neurone signalling" EXACT []
synonym: "glial cell- neuron signalling" EXACT []
synonym: "glial cell-neurone signalling" EXACT []
synonym: "glial cell-neurone singaling" EXACT []
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0150099
name: neuron-glial cell signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368]
synonym: "neuron-glia signaling" EXACT []
synonym: "neuron-glia signalling" EXACT []
synonym: "neuron-glial cell signalling" EXACT []
synonym: "neurone-glia signaling" EXACT []
synonym: "neurone-glia signalling" EXACT []
synonym: "neurone-glial cell signaling" EXACT []
synonym: "neurone-glial cell signalling" EXACT []
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0150101
name: regulation of microtubule anchoring at centrosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome." [GOC:aruk, GOC:bc, PMID:17139249]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0034454 ! microtubule anchoring at centrosome

[Term]
id: GO:0150102
name: negative regulation of monocyte activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation." [GOC:aruk, PMID:15597323]
synonym: "repression of monocyte activation" EXACT []
is_a: GO:0002695 ! negative regulation of leukocyte activation
relationship: negatively_regulates GO:0042117 ! monocyte activation

[Term]
id: GO:0150103
name: reactive gliosis
namespace: biological_process
def: "A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells." [GOC:aruk, GOC:bc, PMID:24462092]
synonym: "gliosis" BROAD []
is_a: GO:0150076 ! neuroinflammatory response

[Term]
id: GO:0150104
name: transport across blood-brain barrier
namespace: biological_process
def: "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008]
synonym: "transport across BBB" EXACT []
synonym: "transport across blood brain barrier" EXACT []
is_a: GO:0010232 ! vascular transport

[Term]
id: GO:0150105
name: protein localization to cell-cell junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:1902414 ! protein localization to cell junction

[Term]
id: GO:0150106
name: regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0150105 ! protein localization to cell-cell junction

[Term]
id: GO:0150107
name: positive regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:0150106 ! regulation of protein localization to cell-cell junction
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:0150105 ! protein localization to cell-cell junction

[Term]
id: GO:0150110
name: obsolete negative regulation of cholesterol esterification
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol esterification." [GOC:aruk, GOC:bc, PMID:21810484, PMID:24201375]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0008203

[Term]
id: GO:0150111
name: regulation of transepithelial transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0070633 ! transepithelial transport

[Term]
id: GO:0150115
name: cell-substrate junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0150116
name: regulation of cell-substrate junction organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0150115 ! cell-substrate junction organization

[Term]
id: GO:0150117
name: positive regulation of cell-substrate junction organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0150116 ! regulation of cell-substrate junction organization
relationship: positively_regulates GO:0150115 ! cell-substrate junction organization

[Term]
id: GO:0150118
name: negative regulation of cell-substrate junction organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0150116 ! regulation of cell-substrate junction organization
relationship: negatively_regulates GO:0150115 ! cell-substrate junction organization

[Term]
id: GO:0150119
name: negative regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc]
synonym: "negative regulation of protein localisation to cell-cell junction" EXACT []
is_a: GO:0150106 ! regulation of protein localization to cell-cell junction
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:0150105 ! protein localization to cell-cell junction

[Term]
id: GO:0150127
name: regulation of interleukin-33 production
namespace: biological_process
alt_id: GO:0150123
alt_id: GO:0150130
def: "Any process that modulates the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524]
synonym: "regulation of interleukin-33 biosynthetic process" NARROW []
synonym: "regulation of interleukin-33 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0072639 ! interleukin-33 production

[Term]
id: GO:0150128
name: negative regulation of interleukin-33 production
namespace: biological_process
alt_id: GO:0150124
alt_id: GO:0150131
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524]
synonym: "negative regulation of interleukin-33 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-33 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0150127 ! regulation of interleukin-33 production
relationship: negatively_regulates GO:0072639 ! interleukin-33 production

[Term]
id: GO:0150129
name: positive regulation of interleukin-33 production
namespace: biological_process
alt_id: GO:0150125
alt_id: GO:0150132
def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 production." [GOC:aruk]
synonym: "positive regulation of interleukin-33 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-33 secretion" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0150127 ! regulation of interleukin-33 production
relationship: positively_regulates GO:0072639 ! interleukin-33 production

[Term]
id: GO:0150136
name: regulation of interleukin-37 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558]
synonym: "regulation of interleukin-37 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0150137 ! interleukin-37 production

[Term]
id: GO:0150137
name: interleukin-37 production
namespace: biological_process
def: "The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:30362558]
subset: gocheck_do_not_annotate
synonym: "interleukin-37 biosynthetic process" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0150138
name: negative regulation of interleukin-37 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558]
synonym: "negative regulation of interleukin-37 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0150136 ! regulation of interleukin-37 production
relationship: negatively_regulates GO:0150137 ! interleukin-37 production

[Term]
id: GO:0150139
name: positive regulation of interleukin-37 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-37 production." [GOC:aruk]
synonym: "positive regulation of interleukin-37 biosynthetic process" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0150136 ! regulation of interleukin-37 production
relationship: positively_regulates GO:0150137 ! interleukin-37 production

[Term]
id: GO:0150140
name: regulation of CD86 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882]
synonym: "regulation of CD86 biosynthetic process" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0035781 ! CD86 biosynthetic process

[Term]
id: GO:0150141
name: negative regulation of CD86 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882]
synonym: "negative regulation of CD86 biosynthetic process" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0150140 ! regulation of CD86 production
relationship: negatively_regulates GO:0035781 ! CD86 biosynthetic process

[Term]
id: GO:0150142
name: positive regulation of CD86 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk]
synonym: "positive regulation of CD86 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0150140 ! regulation of CD86 production
relationship: positively_regulates GO:0035781 ! CD86 biosynthetic process

[Term]
id: GO:0150143
name: regulation of CD80 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882]
synonym: "regulation of CD80 biosynthetic process" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0035780 ! CD80 biosynthetic process

[Term]
id: GO:0150144
name: negative regulation of CD80 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882]
synonym: "negative regulation of CD80 biosynthetic process" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0150143 ! regulation of CD80 production
relationship: negatively_regulates GO:0035780 ! CD80 biosynthetic process

[Term]
id: GO:0150145
name: positive regulation of CD80 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk]
synonym: "positive regulation of CD80 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0150143 ! regulation of CD80 production
relationship: positively_regulates GO:0035780 ! CD80 biosynthetic process

[Term]
id: GO:0150146
name: cell junction disassembly
namespace: biological_process
def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0150147
name: cell-cell junction disassembly
namespace: biological_process
def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267]
is_a: GO:0045216 ! cell-cell junction organization
is_a: GO:0150146 ! cell junction disassembly

[Term]
id: GO:0150151
name: regulation of interleukin-17A production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018]
synonym: "regulation of interleukin-17A biosynthetic process" NARROW []
is_a: GO:0032660 ! regulation of interleukin-17 production
relationship: regulates GO:0097087 ! interleukin-17A production

[Term]
id: GO:0150152
name: negative regulation of interleukin-17A production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018]
synonym: "negative regulation of interleukin-17A biosynthetic process" NARROW []
is_a: GO:0032700 ! negative regulation of interleukin-17 production
is_a: GO:0150151 ! regulation of interleukin-17A production
relationship: negatively_regulates GO:0097087 ! interleukin-17A production

[Term]
id: GO:0150153
name: positive regulation of interleukin-17A production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-17A production." [GOC:aruk]
synonym: "positive regulation of interleukin-17A biosynthetic process" NARROW []
is_a: GO:0032740 ! positive regulation of interleukin-17 production
is_a: GO:0150151 ! regulation of interleukin-17A production
relationship: positively_regulates GO:0097087 ! interleukin-17A production

[Term]
id: GO:0150155
name: interleukin-34 production
namespace: biological_process
def: "The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:26754294]
subset: gocheck_do_not_annotate
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0150157
name: regulation of interleukin-34 production
namespace: biological_process
alt_id: GO:0150156
alt_id: GO:0150160
def: "Any process that modulates the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294]
synonym: "interleukin-34 biosynthetic process" NARROW []
synonym: "regulation of interleukin-34 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0150155 ! interleukin-34 production

[Term]
id: GO:0150158
name: positive regulation of interleukin-34 production
namespace: biological_process
alt_id: GO:0150161
def: "Any process that activates or increases the frequency, rate or extent of interleukin-34 production." [GOC:aruk]
synonym: "positive regulation of interleukin-34 biosynthetic process" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0150157 ! regulation of interleukin-34 production
relationship: positively_regulates GO:0150155 ! interleukin-34 production

[Term]
id: GO:0150159
name: negative regulation of interleukin-34 production
namespace: biological_process
alt_id: GO:0150162
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294]
synonym: "negative regulation of interleukin-34 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0150157 ! regulation of interleukin-34 production
relationship: negatively_regulates GO:0150155 ! interleukin-34 production

[Term]
id: GO:0150163
name: obsolete miRNA-mediated activation of transcription by RNA polymerase II
namespace: biological_process
def: "OBSOLETE. Any process mediated by a microRNA (miRNA) that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:aruk, PMID:20737563, PMID:27145859]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0150164
name: obsolete miRNA-mediated regulation of transcription by RNA polymerase II
namespace: biological_process
def: "OBSOLETE. Any process mediated by a microRNA (miRNA) that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:aruk, PMID:20737563, PMID:27145859]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0150165
name: obsolete miRNA-mediated inhibition of transcription by RNA polymerase II
namespace: biological_process
def: "OBSOLETE. Any process mediated by a microRNA (miRNA) that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:aruk]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:0150166
name: obsolete regulation of histone H3-K4 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K4 acetylation." [GOC:aruk]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0044016

[Term]
id: GO:0150167
name: obsolete positive regulation of histone H3-K4 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K4 acetylation." [GOC:aruk, PMID:20737563]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0044016

[Term]
id: GO:0150168
name: obsolete negative regulation of histone H3-K4 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 acetylation." [GOC:aruk]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:0150172
name: regulation of phosphatidylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: regulates GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0150173
name: positive regulation of phosphatidylcholine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
relationship: positively_regulates GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0150174
name: negative regulation of phosphatidylcholine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
relationship: negatively_regulates GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0150175
name: regulation of phosphatidylethanolamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylethanolamine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: regulates GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0150176
name: positive regulation of phosphatidylethanolamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylethanolamine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:0150175 ! regulation of phosphatidylethanolamine metabolic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
relationship: positively_regulates GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0150177
name: negative regulation of phosphatidylethanolamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylethanolamine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:0150175 ! regulation of phosphatidylethanolamine metabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
relationship: negatively_regulates GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0150178
name: regulation of phosphatidylserine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: regulates GO:0006658 ! phosphatidylserine metabolic process

[Term]
id: GO:0150179
name: positive regulation of phosphatidylserine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:0150178 ! regulation of phosphatidylserine metabolic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
relationship: positively_regulates GO:0006658 ! phosphatidylserine metabolic process

[Term]
id: GO:0150180
name: negative regulation of phosphatidylserine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985]
is_a: GO:0150178 ! regulation of phosphatidylserine metabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
relationship: negatively_regulates GO:0006658 ! phosphatidylserine metabolic process

[Term]
id: GO:0150189
name: regulation of interleukin-32 production
namespace: biological_process
alt_id: GO:0150192
def: "Any process that modulates the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669]
synonym: "regulation of interleukin-32 biosynthetic process" NARROW []
synonym: "regulation of interleukin-32 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0072637 ! interleukin-32 production

[Term]
id: GO:0150190
name: negative regulation of interleukin-32 production
namespace: biological_process
alt_id: GO:0150193
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669]
synonym: "negative regulation of interleukin-32 biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-32 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0150189 ! regulation of interleukin-32 production
relationship: negatively_regulates GO:0072637 ! interleukin-32 production

[Term]
id: GO:0150191
name: positive regulation of interleukin-32 production
namespace: biological_process
alt_id: GO:0150194
def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 production." [GOC:aruk]
synonym: "positive regulation of interleukin-32 biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-32 secretion" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0150189 ! regulation of interleukin-32 production
relationship: positively_regulates GO:0072637 ! interleukin-32 production

[Term]
id: GO:0150195
name: transport across blood-cerebrospinal fluid barrier
namespace: biological_process
def: "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier." [GOC:aruk, GOC:bc, PMID:21349151]
synonym: "transport across BCSFB" EXACT []
synonym: "transport across blood-CSF barrier" EXACT []
synonym: "transport across blood/cerebrospinal fluid barrier" EXACT []
synonym: "transport across blood/CSF barrier" EXACT []
is_a: GO:0010232 ! vascular transport

[Term]
id: GO:0150200
name: regulation of transport across blood-brain barrier
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0051049 ! regulation of transport
relationship: part_of GO:0043114 ! regulation of vascular permeability
relationship: regulates GO:0150104 ! transport across blood-brain barrier

[Term]
id: GO:0150201
name: positive regulation of transport across blood-brain barrier
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0150200 ! regulation of transport across blood-brain barrier
relationship: part_of GO:0043117 ! positive regulation of vascular permeability
relationship: positively_regulates GO:0150104 ! transport across blood-brain barrier

[Term]
id: GO:0150202
name: negative regulation of transport across blood-brain barrier
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0150200 ! regulation of transport across blood-brain barrier
relationship: negatively_regulates GO:0150104 ! transport across blood-brain barrier
relationship: part_of GO:0043116 ! negative regulation of vascular permeability

[Term]
id: GO:0151001
name: tuft
namespace: cellular_component
def: "A dense cluster of elongated, thick microvilli on the apical surface of tuft cells in epithelial tissues, such as the intestine and respiratory tract. The apical tuft extends further into the lumen than typical microvilli, featuring larger, more compact projections with unique actin cores that penetrate deep into the cytoplasm, often reaching the perinuclear region. This distinctive structure, rich in microfilaments and microtubules, supports the chemosensory functions of the cell." [PMID:15817800, PMID:35237268]
is_a: GO:0098862 ! cluster of actin-based cell projections

[Term]
id: GO:0160001
name: extrasynaptic signaling via GABA
namespace: biological_process
def: "Cell-cell signaling that starts with the activation of extrasynaptic GABA receptors in neurons through binding of ambient gamma-aminobutyric acid present in the extracellular fluid." [PMID:23038269, PMID:9364051]
is_a: GO:0007214 ! gamma-aminobutyric acid signaling pathway

[Term]
id: GO:0160002
name: ADP-D-ribose modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon ADP-ribosylation of the target protein." [PMID:26673700]
comment: This term should only be used when the binding is shown to require a ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
is_a: GO:0140030 ! modification-dependent protein binding

[Term]
id: GO:0160003
name: mono-ADP-D-ribose modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon mono-ADP-ribosylation of the target protein." [PMID:34023495]
comment: This term should only be used when the binding is shown to require a mono-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
is_a: GO:0160002 ! ADP-D-ribose modification-dependent protein binding

[Term]
id: GO:0160004
name: poly-ADP-D-ribose modification-dependent protein binding
namespace: molecular_function
def: "Binding to a protein upon poly-ADP-ribosylation of the target protein." [PMID:26673700]
comment: This term should only be used when the binding is shown to require a poly-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
is_a: GO:0160002 ! ADP-D-ribose modification-dependent protein binding

[Term]
id: GO:0160005
name: PAT complex
namespace: cellular_component
def: "A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47." [PMID:32814900, PMID:33082068, PMID:33960686]
comment: PAT complex functions by shielding exposed hydrophilicity of transmembrane domains (TMDs) to prevent premature degradation and promote proper folding and bundling of TMDs.
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0160006
name: Fc receptor-mediated immune complex endocytosis
namespace: biological_process
def: "An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I." [PMID:28389502, PMID:9143687, PMID:9463401]
synonym: "antigen-antibody immune complex uptake via Fc receptor" EXACT []
synonym: "Fc receptor-mediated immune complex internalization" RELATED []
synonym: "Ig-complexed antigen endocytosis via Fc receptor" EXACT []
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0031503 ! protein-containing complex localization

[Term]
id: GO:0160007
name: glutathione import into mitochondrion
namespace: biological_process
def: "The process in which glutathione is transported from the cytosol into the mitochondrial matrix." [PMID:34707288]
is_a: GO:0034775 ! glutathione transmembrane transport
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:0160008
name: protein decrotonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]." [PMID:28497810, PMID:30279482, PMID:34608293]
xref: RHEA:69172
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0160009
name: histone decrotonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]." [PMID:28497810]
is_a: GO:0140993 ! histone modifying activity
is_a: GO:0160008 ! protein decrotonylase activity

[Term]
id: GO:0160010
name: protein de-2-hydroxyisobutyrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]." [PMID:29192674]
xref: RHEA:69176
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0160011
name: NAD-dependent protein decrotonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:28497810]
xref: RHEA:69332
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0160012
name: NAD-dependent histone decrotonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide." [PMID:28497810]
is_a: GO:0160009 ! histone decrotonylase activity
is_a: GO:0160011 ! NAD-dependent protein decrotonylase activity

[Term]
id: GO:0160013
name: NAD-dependent protein de-2-hydroxyisobutyrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:31328167]
xref: RHEA:24364
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0160014
name: exopher
namespace: cellular_component
def: "An extracellular vesicle that is approximately four microns in diameter, released by budding out of cells into the extracellular space, and hypothesized to be a mechanism for disposal of unwanted cellular material including protein aggregates and damaged organelles." [PMID:28178240, PMID:33016946, PMID:33027673, PMID:33659873, PMID:34288362, PMID:34475208]
is_a: GO:1903561 ! extracellular vesicle

[Term]
id: GO:0160015
name: platelet rolling
namespace: biological_process
def: "Transient adhesive interactions between platelets and endothelial cells lining blood vessels. Carbohydrates on circulating platelets bind selectins or other molecules on the vessel wall causing the platelets to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between surface molecules of platelets and endothelium." [GOC:sl, PMID:29018081]
is_a: GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0160016
name: CCACCA tRNA nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an unstable tRNA + 2 ATP + 4 CTP = a tRNA with a 3' CCACCA end + 6 diphosphate." [PMID:22076379]
is_a: GO:0004810 ! CCA tRNA nucleotidyltransferase activity

[Term]
id: GO:0160017
name: regulation of platelet rolling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of platelet rolling." [GO_REF:0000058, GOC:sl]
is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion
relationship: regulates GO:0160015 ! platelet rolling

[Term]
id: GO:0160018
name: positive regulation of platelet rolling
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of platelet rolling." [GO_REF:0000058, GOC:sl]
is_a: GO:0034116 ! positive regulation of heterotypic cell-cell adhesion
is_a: GO:0160017 ! regulation of platelet rolling
relationship: positively_regulates GO:0160015 ! platelet rolling

[Term]
id: GO:0160019
name: negative regulation of platelet rolling
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of platelet rolling." [GO_REF:0000058, GOC:sl, PMID:15738422]
is_a: GO:0034115 ! negative regulation of heterotypic cell-cell adhesion
is_a: GO:0160017 ! regulation of platelet rolling
relationship: negatively_regulates GO:0160015 ! platelet rolling

[Term]
id: GO:0160020
name: positive regulation of ferroptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferroptosis." [PMID:32015325]
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0110075 ! regulation of ferroptosis
relationship: positively_regulates GO:0097707 ! ferroptosis

[Term]
id: GO:0160021
name: maternal-to-zygotic transition of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome." [PMID:19204068, PMID:32558204]
synonym: "MZT" RELATED []
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0160022
name: apocrine secretion
namespace: biological_process
def: "The controlled release of a substance by a cell or a tissue by discharging a portion of the secreting cell when intracellular components are freed into a lumen through the shedding of whole pieces of the cytoplasm." [PMID:25960390]
synonym: "secretion by cell decapitation" RELATED [ORCID:0000-0002-2825-0621]
synonym: "secretion by membrane budding" RELATED [ORCID:0000-0002-2825-0621]
is_a: GO:0046903 ! secretion

[Term]
id: GO:0160023
name: sneeze reflex
namespace: biological_process
def: "A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane." [https://www.thefreedictionary.com/sneeze, PMID:34133943]
synonym: "sternutation" EXACT [https://en.wikipedia.org/wiki/Sneeze]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0160024
name: Leydig cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone." [PMID:29632025]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:0160025
name: sensory perception of itch
namespace: biological_process
def: "A sensory perception which causes the desire or reflex to scratch." [PMID:26015312, PMID:29723501, PMID:30734045, Wikipedia:Itch]
synonym: "pruritus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0160027
name: egg deposition
namespace: biological_process
def: "The multicellular organismal reproductive process that results in the movement of an egg from within an organism into the external environment." [PMID:18050396, PMID:31164023]
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0160028
name: negative regulation of pyroptotic inflammatory response
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a pyroptotic inflammatory response." [PMID:34637033]
synonym: "negative regulation of pyroptosis" BROAD []
is_a: GO:0050728 ! negative regulation of inflammatory response
relationship: negatively_regulates GO:0070269 ! pyroptotic inflammatory response

[Term]
id: GO:0160029
name: kidney cortex tubule cell dedifferentiation
namespace: biological_process
def: "The process in which a kidney cortex tubule cell (specialized epithelial cell of the kidney) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [PMID:18987110, PMID:31847447]
comment: Following injury, renal cortex tubular epithelial cell appears to be undergoing epithelial-mesenchymal transition, detected by overexpression of vimentin. {xref="PMID:31847447"}
is_a: GO:0043697 ! cell dedifferentiation

[Term]
id: GO:0160030
name: pollen intine formation
namespace: biological_process
def: "Formation of pollen intine, the inner layer of the pollen wall. The reticulate pollen wall pattern consists of two layers, exine and intine." [PMID:35498668]
is_a: GO:0010208 ! pollen wall assembly

[Term]
id: GO:0160031
name: endoplasmic reticulum membrane biogenesis
namespace: biological_process
def: "The process in which an endoplasmic reticulum membrane is synthesized, aggregates, and bonds together." [PMID:19825355, PMID:24373967, PMID:34617598]
synonym: "ER membrane biogenesis" EXACT []
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization

[Term]
id: GO:0160032
name: Toll receptor ligand protein activation cascade
namespace: biological_process
def: "A protein activation cascade that generates the active Toll receptor ligand and consists of the cascade of enzymatic reactions initiated by extracellular recognition factors, leading to the cleavage of the inactive form of spatzle family of ligands." [PMID:23632253]
comment: This term specifically mentions the Toll receptor and its ligand spatzle because this is the only known example of such an activation cascade for a ligand.
is_a: GO:0072376 ! protein activation cascade

[Term]
id: GO:0160033
name: regulation of Toll receptor ligand protein activation cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Toll receptor ligand protein activation cascade." [PMID:23632253]
is_a: GO:2000257 ! regulation of protein activation cascade
relationship: regulates GO:0160032 ! Toll receptor ligand protein activation cascade

[Term]
id: GO:0160034
name: positive regulation of Toll receptor ligand protein activation cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Toll receptor ligand protein activation cascade." [PMID:23632253]
is_a: GO:0160033 ! regulation of Toll receptor ligand protein activation cascade
is_a: GO:2000259 ! positive regulation of protein activation cascade
relationship: positively_regulates GO:0160032 ! Toll receptor ligand protein activation cascade

[Term]
id: GO:0160035
name: negative regulation of Toll receptor ligand protein activation cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Toll receptor ligand protein activation cascade." [PMID:23632253]
is_a: GO:0160033 ! regulation of Toll receptor ligand protein activation cascade
is_a: GO:2000258 ! negative regulation of protein activation cascade
relationship: negatively_regulates GO:0160032 ! Toll receptor ligand protein activation cascade

[Term]
id: GO:0160036
name: positive regulation of postsynaptic density assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of postsynaptic density assembly." [PMID:17626212]
is_a: GO:0099151 ! regulation of postsynaptic density assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1905876 ! positive regulation of postsynaptic density organization
relationship: positively_regulates GO:0097107 ! postsynaptic density assembly

[Term]
id: GO:0160037
name: negative regulation of postsynaptic density assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of postsynaptic density assembly." [PMID:17626212]
is_a: GO:0099151 ! regulation of postsynaptic density assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1905875 ! negative regulation of postsynaptic density organization
relationship: negatively_regulates GO:0097107 ! postsynaptic density assembly

[Term]
id: GO:0160038
name: somatic sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain." [PMID:25832476, PMID:31399790]
synonym: "somatosensory system development" EXACT []
is_a: GO:0048880 ! sensory system development

[Term]
id: GO:0160039
name: serotonin-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [PMID:11100728]
xref: TC:1.A.9
xref: Wikipedia:Ligand-gated_ion_channel
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity
is_a: GO:0099589 ! serotonin receptor activity

[Term]
id: GO:0160040
name: mitocytosis
namespace: biological_process
def: "A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells." [PMID:34108688]
is_a: GO:0048311 ! mitochondrion distribution
is_a: GO:0051654 ! establishment of mitochondrion localization
is_a: GO:0140495 ! migracytosis

[Term]
id: GO:0160041
name: neuropeptide activity
namespace: molecular_function
def: "The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron." [PMID:18806786, PMID:21922398]
is_a: GO:0048018 ! receptor ligand activity

[Term]
id: GO:0160042
name: purine nucleotide uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [PMID:18375752, PMID:27477609]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity

[Term]
id: GO:0160043
name: catecholamine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter." [PMID:10191060]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0160044
name: sulfate:chloride antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in)." [PMID:17442754]
is_a: GO:0005452 ! solute:inorganic anion antiporter activity
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0160045
name: TMEM240-body
namespace: cellular_component
def: "A multilamellar subcellular structure formed in the cytoplasm of developing neuron, composed of Tmem240 and Emd proteins." [PMID:32535204]
synonym: "T240-body" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0160046
name: oxalate:chloride antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + oxalate(in) = chloride(in) + oxalate(out)." [PMID:17442754]
is_a: GO:0005452 ! solute:inorganic anion antiporter activity
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0019531 ! oxalate transmembrane transporter activity
is_a: GO:0022853 ! active monoatomic ion transmembrane transporter activity

[Term]
id: GO:0160047
name: muramyl dipeptide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + muramyl dipeptide = ADP + H+ + 6-O-phospho-muramyl dipeptide." [PMID:36002575]
xref: RHEA:75935
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0160048
name: craniofacial suture closure
namespace: biological_process
def: "The process of fusing together the edges of a craniofacial suture." [PMID:33842480]
is_a: GO:0060349 ! bone morphogenesis

[Term]
id: GO:0160049
name: negative regulation of cGAS/STING signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway." [PMID:29875158]
is_a: GO:0039532 ! negative regulation of cytoplasmic pattern recognition receptor signaling pathway
relationship: negatively_regulates GO:0140896 ! cGAS/STING signaling pathway

[Term]
id: GO:0160050
name: xanthine binding
namespace: molecular_function
def: "Binding to xanthine, a purine base." [PMID:32345632, PMID:34125892]
is_a: GO:0002060 ! purine nucleobase binding

[Term]
id: GO:0160051
name: Cyc8(Ssn6)-Tup1 general repressor complex
namespace: cellular_component
def: "A corepressor complex containing the WD-repeat protein Tup1p (S. cerevisiae) and Tup11/Tup12 (fission yeast) and the TPR repeat protein Cyc8p (S. cerevisiae) ssn6 (fission yeast) that is recruited to target genes by DNA-bound repressor proteins preferentially at regions where histones are deacetylated by the Clr6 class I HDAC, and recruits the SWI/SNF and SAGA complexes to promoters." [GOC:vw, PMID:10871883, PMID:17101775, PMID:22156212]
synonym: "Tup11/Tup12 repressor complex" EXACT []
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0160052
name: mitotic nuclear envelope segregation
namespace: biological_process
def: "The mitotic cell cycle process in which the nuclear envelope, including nuclear pores, is equally distributed to the two daughter cells during the mitotic cell cycle." [GOC:vw, PMID:24184107]
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0160053
name: serine-based site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphoseryl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a serine in the active site." [PMID:16756503, PMID:29316791]
is_a: GO:0009009 ! site-specific recombinase activity

[Term]
id: GO:0160054
name: microfibril assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of microfibril." [PMID:32855533]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:0160055
name: glideosome
namespace: cellular_component
def: "A protein complex composed of at least GAP45 (gliding-associated protein), GAP50 and myosin heavy and light chains. Anchored via GAP50 to the inner membrane complex of motile and invasive forms of apicomplexan parasites and regulates parasite gliding motility and invasion of host cells." [PMID:12139608, PMID:15123738, PMID:19577950]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0160056
name: macropinosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a macropinosome." [PMID:19690049]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0044354 ! macropinosome

[Term]
id: GO:0160057
name: plant endodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a plant endodermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [PMID:26415082]
is_a: GO:0001708 ! cell fate specification

[Term]
id: GO:0160058
name: plant endodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a plant endodermal cell." [PMID:21735349]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0160059
name: programmed cell death in response to retinoic acid
namespace: biological_process
def: "Cell death resulting from activation of endogenous cellular processes and occurring as a result of a retinoic acid." [PMID:17869331, PMID:9187263]
synonym: "retinoic acid-induced apoptosis" EXACT []
is_a: GO:0012501 ! programmed cell death
relationship: part_of GO:0071300 ! cellular response to retinoic acid

[Term]
id: GO:0160060
name: sleep homeostasis
namespace: biological_process
def: "A homeostatic process in which the drive for sleep increases sleep propensity with prolonged wakefulness." [PMID:30509635]
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0160061
name: respiratory chemosensitivity
namespace: biological_process
def: "A homeostatic process by which the sensing of CO2 and/or H+ by the brain leads to appropriate altering in breathing to regulate blood gas and tissue pH." [PMID:26068853]
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0160062
name: cutin-based cuticle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cutin-based cuticle over time, from its formation to the mature structure. Cutin-based cuticle is an extracellular structure composed of a covalently linked macromolecular scaffold of cutin and a variety of organic solvent-soluble lipids that are collectively termed waxes. Such structures are found on the external face of polysaccharide cell walls in land plants." [PMID:23893170]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0160063
name: multi-pass transmembrane protein insertion into ER membrane
namespace: biological_process
def: "A process of protein insertion of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Insertion of multi-pass membrane proteins is mediated by the multi-pass translocon complex and takes place following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex to promote insertion of subsequent transmembrane regions." [PMID:36261522, PMID:36261528]
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0160064
name: multi-pass translocon complex
namespace: cellular_component
def: "A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47)." [PMID:36261522, PMID:36261528]
synonym: "MPT complex" EXACT []
synonym: "TMCO1 translocon" RELATED []
is_a: GO:0072379 ! ER membrane insertion complex

[Term]
id: GO:0160065
name: SIN/MEN signaling complex
namespace: cellular_component
def: "A protein complex associated with the mitotic spindle pole body during interphase and mitosis and comprises of the proteins of the septation initiation signaling network (SIN) of fission yeast or mitotic exit network (MEN) of budding yeast, organized by two scaffold/adaptor proteins." [PMID:21131906, PMID:22525225, PMID:22684255]
synonym: "Hippo signaling complex" NARROW []
synonym: "MEN signaling complex" NARROW []
synonym: "SIN signaling complex" NARROW []
synonym: "SIN/MEN signalling complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0061499 ! outer plaque of mitotic spindle pole body

[Term]
id: GO:0160066
name: interphase SIN signaling complex
namespace: cellular_component
def: "A SIN signaling complex associated with the old mitotic spindle pole body during interphase and early M-phase and characterised by the presence active ubiquitin ligase (Dma1 in fission yeast) and GTPase activator (Spg1 in fission yeast) to inactivate SIN signaling." [PMID:21131906]
synonym: "interphase SIN signalling complex" EXACT []
is_a: GO:0160065 ! SIN/MEN signaling complex

[Term]
id: GO:0160067
name: new spindle pole body SIN signaling complex
namespace: cellular_component
def: "A SIN signaling complex associated with the new mitotic spindle pole body during anaphase and characterized by the presence activated (GTP bound) GTPase (Spg1 in fission yeast) to activate SIN signaling." [PMID:21131906]
synonym: "new spindle pole body SIN signalling complex" EXACT []
is_a: GO:0160065 ! SIN/MEN signaling complex

[Term]
id: GO:0160068
name: negative regulation of pollen tube guidance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of pollen tube guidance towards ovules. This is one mechanism to prevent polytuby, the simultaneous penetration of ovules by multiple pollen tubes." [PMID:33790463]
synonym: "prevention of polytuby" BROAD []
is_a: GO:0050928 ! negative regulation of positive chemotaxis
relationship: negatively_regulates GO:0010183 ! pollen tube guidance

[Term]
id: GO:0160069
name: surfactant secretion
namespace: biological_process
def: "The regulated release of surfactant by a cell or tissue." [PMID:19824815]
is_a: GO:0046903 ! secretion
relationship: part_of GO:0043129 ! surfactant homeostasis

[Term]
id: GO:0160070
name: intracellular borate homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of tetrahydroxoborate within a cell." [PMID:15525507]
synonym: "intracellular boron homeostasis" EXACT []
synonym: "intracellular tetrahydroxoborate homeostasis" EXACT []
is_a: GO:0055082 ! intracellular chemical homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0160071
name: prevention of polyspermy during double fertilization
namespace: biological_process
def: "The regulation of double fertilization forming a zygote and endosperm process that ensures that only a single sperm cell fertilizes one egg cell and another single sperm cell fertilizes one central cell." [PMID:27951463]
is_a: GO:0080155 ! regulation of double fertilization forming a zygote and endosperm

[Term]
id: GO:0160072
name: ubiquitin ligase complex scaffold activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way." [PMID:27664236]
synonym: "core protein activity for the CUL-RING ubiquitin ligase complex" NARROW []
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:0160073
name: Casparian strip assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Casparian strip, a region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material." [PMID:28104889]
synonym: "Casparian strip formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0071668 ! plant-type cell wall assembly

[Term]
id: GO:0160074
name: non-canonical inflammasome complex
namespace: cellular_component
def: "An inflammasome complex containing CASP4, known as caspase-11 (Casp11) in mouse, which assembles upon cytosolic lipopolysaccharide-binding and directly activates Gasdermin-D (GSDMD)." [PMID:33187725]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0160075
name: non-canonical inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a non-canonical inflammasome complex." [PMID:27291964]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0160076
name: negative regulation of non-canonical inflammasome complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical inflammasome complex assembly." [PMID:22002608, PMID:26375259]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
relationship: negatively_regulates GO:0160075 ! non-canonical inflammasome complex assembly
relationship: part_of GO:0141086 ! negative regulation of inflammasome-mediated signaling pathway

[Term]
id: GO:0160077
name: lipid droplet fusion
namespace: biological_process
def: "The process by which a single lipid droplet is created from the fusion of two or more lipid droplets." [PMID:34508658, PMID:36477540]
is_a: GO:0034389 ! lipid droplet organization
is_a: GO:0048284 ! organelle fusion

[Term]
id: GO:0160078
name: negative regulation of lipid droplet fusion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipid droplet fusion." [PMID:36477540]
is_a: GO:0010639 ! negative regulation of organelle organization
relationship: negatively_regulates GO:0160077 ! lipid droplet fusion

[Term]
id: GO:0160079
name: G protein-coupled glycine receptor activity
namespace: molecular_function
def: "Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signaling." [PMID:36996198]
synonym: "metabotropic glycine receptor activity" EXACT []
synonym: "mGlyR" EXACT []
is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity

[Term]
id: GO:0160080
name: ABC-type indole transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + indole(in) = ADP + phosphate + indole(out)." [PMID:37146609]
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:0160081
name: iodide channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of iodide through a transmembrane aqueous pore or channel." [PMID:34910516]
xref: Reactome:R-HSA-429767 "Passive I- efflux mediated by SLC5A8"
is_a: GO:0005253 ! monoatomic anion channel activity
is_a: GO:0015111 ! iodide transmembrane transporter activity

[Term]
id: GO:0160082
name: hypoxia-inducible factor-proline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]." [PMID:11595184, PMID:11598268]
synonym: "HIF hydroxylase" BROAD []
synonym: "HIF prolyl hydroxylase" EXACT []
xref: EC:1.14.11.29
xref: RHEA:48400
is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity

[Term]
id: GO:0160083
name: exhausted T cell differentiation
namespace: biological_process
def: "The process in which an activated T cell acquires specialized features of an exhausted T cell." [PMID:21739672, PMID:31570879]
synonym: "T cell dysfuction" RELATED []
synonym: "T cell exhaustion" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0160086
name: protein localization to polar microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a polar microtubule." [PMID:34080538]
is_a: GO:1902889 ! protein localization to spindle microtubule

[Term]
id: GO:0160087
name: spermatid cytoplasm removal during spermiation of flagellated sperm
namespace: biological_process
def: "The process of removing the majority of the cytoplasm and organelles from a spermatid as it develops into a mature flagellated sperm cell." [PMID:21866274, PMID:23087837]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0160089
name: internal N(7)-methylguanine-containing RNA reader activity
namespace: molecular_function
def: "A protein adaptor that recognizes and binds an RNA molecule modified by N(7)-methylguanine (m7G), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:37379838]
is_a: GO:0140517 ! protein-RNA adaptor activity

[Term]
id: GO:0160090
name: internal mRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine." [PMID:31031084, PMID:37379838, RHEA:60508]
xref: RHEA:60508
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0160091
name: spliceosome-depend formation of circular RNA
namespace: biological_process
def: "Formation of circular RNAs (circRNAs) by back-splicing circularization of pre-mRNAs in a spliceosome-dependent process." [PMID:25768908, PMID:28625552]
is_a: GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0160092
name: hemozoin formation complex
namespace: cellular_component
def: "A protein-containing complex involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage of a Plasmodium. It is composed of at least falcipains FP2A and/or FP2B, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN." [PMID:23471987]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0160093
name: chordate pharynx development
namespace: biological_process
def: "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure." [PMID:23020903]
is_a: GO:0060465 ! pharynx development

[Term]
id: GO:0160094
name: nematode pharynx development
namespace: biological_process
def: "The process whose specific outcome is the progression of nematode pharynx over time, from its formation to the mature structure." [PMID:18050503]
is_a: GO:0060465 ! pharynx development

[Term]
id: GO:0160095
name: insect pharynx development
namespace: biological_process
def: "The process whose specific outcome is the progression of insect pharynx over time, from its formation to the mature structure." [PMID:10952900]
is_a: GO:0060465 ! pharynx development

[Term]
id: GO:0160096
name: nematode pharyngeal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nematode pharyngeal muscle over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development
relationship: part_of GO:0160094 ! nematode pharynx development

[Term]
id: GO:0160097
name: reverse gyrase activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle, is driven by ATP hydrolysis." [PMID:25013168]
xref: WIKIPEDIA:Reverse_gyrase
is_a: GO:0003916 ! DNA topoisomerase activity

[Term]
id: GO:0160101
name: tRNA (guanine(10)-N2)-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine." [EC:2.1.1.213]
synonym: "N(2),N(2)-dimethylguanosine tRNA methyltransferase" EXACT []
synonym: "tRNA (guanine(10)-N(2))-dimethyltransferase activity" EXACT []
synonym: "tRNA (guanosine(10)-N(2))-dimethyltransferase activity" EXACT []
xref: EC:2.1.1.213
xref: RHEA:43124
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0160102
name: tRNA (guanine(10)-N2)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine(10) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.214]
synonym: "tRNA (guanine(10)-N(2))-methyltransferase activity" EXACT []
synonym: "tRNA (guanosine(10)-N(2))-methyltransferase activity" EXACT []
xref: EC:2.1.1.214
xref: Reactome:R-HSA-6786501 "TRMT11:TRMT112 methylates guanosine-10 in tRNA"
xref: RHEA:43128
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0160103
name: tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H+ + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine." [EC:2.1.1.215]
synonym: "tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase activity" EXACT []
synonym: "tRNA (guanosine(26)-N(2)/guanosine(27)-N(2))-dimethyltransferase activity" EXACT []
xref: EC:2.1.1.215
xref: RHEA:43136
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0160104
name: tRNA (guanine(26)-N2)-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction:guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine." [EC:2.1.1.216]
synonym: "tRNA (guanine(26)-N(2))-dimethyltransferase activity" EXACT []
synonym: "tRNA (guanosine(26)-N(2))-dimethyltransferase activity" EXACT []
synonym: "tRNA (m(2)2G26)dimethyltransferase" EXACT []
xref: EC:2.1.1.216
xref: Reactome:R-HSA-6782416 "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)"
xref: RHEA:43140
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0160105
name: tRNA (adenine(22)-N1)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine(22) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.217]
synonym: "tRNA (adenine(22)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA (adenosine(22)-N(1))-methyltransferase activity" EXACT []
xref: EC:2.1.1.217
xref: RHEA:43144
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0160106
name: tRNA (adenine(9)-N1)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine(9) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.218]
synonym: "tRNA (adenine(9)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA m(1)A(9)-methyltransferase" EXACT []
synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase" EXACT []
xref: EC:2.1.1.218
xref: Reactome:R-HSA-6787594 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9"
xref: RHEA:43148
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0160107
name: tRNA (adenine(58)-N1)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.220]
synonym: "tRNA (adenine(58)-N(1))-methyltransferase activity" EXACT []
synonym: "tRNA (m(1)A(58)) methyltransferase" EXACT []
synonym: "tRNA m(1)A(58) methyltransferase" EXACT []
xref: EC:2.1.1.220
xref: Reactome:R-HSA-6783492 "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)"
xref: Reactome:R-HSA-6787525 "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58"
xref: RHEA:43152
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0160108
name: animal gross anatomical part developmental process
namespace: biological_process
def: "Any developmental process whose specific outcome is the progression of a gross anatomical part of an animal from an initial immature state, to a later, more mature state." [GOC:pg]
synonym: "animal development" RELATED []
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0160109
name: plant gross anatomical part developmental process
namespace: biological_process
def: "Any developmental process whose specific outcome is the progression of a gross anatomical part of a plant from an initial immature state, to a later, more mature state." [GOC:pg]
synonym: "plant development" RELATED []
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0160110
name: axonemal microtubule doublet inner sheath
namespace: cellular_component
def: "A structural network of microtubule inner proteins (MIPs) located inside the lumens of the A and B tubules of the axonemal microtuble doublet that helps stabilize the doublet microtubule." [GOC:krc, PMID:29430673, PMID:37295417]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097545 ! axonemal doublet microtubule

[Term]
id: GO:0160111
name: axonemal A tubule inner sheath
namespace: cellular_component
def: "A structural network of microtubule inner proteins (MIPs) located inside the lumen of the A tubule of the axonemal microtubule doublet that helps stabilize the A tubule." [GOC:krc, PMID:29430673, PMID:37295417]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097649 ! A axonemal microtubule
relationship: part_of GO:0160110 ! axonemal microtubule doublet inner sheath

[Term]
id: GO:0160112
name: axonemal B tubule inner sheath
namespace: cellular_component
def: "A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule." [GOC:krc, PMID:29430673, PMID:37295417]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097649 ! A axonemal microtubule
relationship: part_of GO:0160110 ! axonemal microtubule doublet inner sheath

[Term]
id: GO:0160113
name: axonemal microtubule doublet inner junction
namespace: cellular_component
def: "The structure which joins the B10 protofilament of the B tubule to the A1 protofilament of the A tubule within an axonemal microtubule doublet." [GOC:krc, PMID:29430673, PMID:37295417]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097545 ! axonemal doublet microtubule

[Term]
id: GO:0160114
name: axonemal microtubule doublet outer junction
namespace: cellular_component
def: "The structure which joins the B1 protofilament of the B tubule to the A10 and A11 protofilaments of the A tubule within an axonemal microtubule doublet." [GOC:krc, PMID:29430673, PMID:37295417]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097545 ! axonemal doublet microtubule

[Term]
id: GO:0160115
name: axonemal microtubule doublet ribbon
namespace: cellular_component
def: "The 3 protofilaments A11, A12, and A13 of the A tubule along with associated inner sheath microtuble inner proteins (MIPs), either in the lumen of the A tubule or of the B tubule, which stabilize these three filiments within the axonemal doublet microtubule. The ribbon protofilaments separate the lumens of the A and B tubules." [GOC:krc, PMID:1262413, PMID:29430673]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097545 ! axonemal doublet microtubule

[Term]
id: GO:0160117
name: tRNA (guanine(6)-N2)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine(6) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.256, PMID:34669960]
synonym: "m(2)G6 methyltransferase" EXACT []
synonym: "methyltransferase Trm14" EXACT []
xref: EC:2.1.1.256
xref: RHEA:51116
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0160118
name: tRNA (guanine(7)-N2)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine(7) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(7) in tRNA + S-adenosyl-L-homocysteine." [PMID:34669960]
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0160119
name: cuproptosis
namespace: biological_process
def: "A programmed cell death process that is induced by intracellular copper accumulation." [PMID:35298263, PMID:35354936]
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0160120
name: obsolete mitochondrial branched-chain alpha-keto acid dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A mitochondrial complex that catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex is organized around a 24-meric cubic core of the dihydrolipoyl transacylase (E2) with multiple (about 6 to 12) copies of the branched-chain alpha-ketoacid dehydrogenase (E1, consisting of alpha and beta subunits), about 6 copies of the dimeric dihydrolipoyl dehydrogenase (E3), and a small number of copies of the E1-specific kinase and phosphatase." [PMID:10745006, PMID:3593587, PMID:9582350]
comment: This term is unnecessarily taxon-specific.
synonym: "BCKD complex" EXACT []
is_obsolete: true
replaced_by: GO:0160157

[Term]
id: GO:0160121
name: bis(monoacylglycero)phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)." [PMID:37708259, RHEA:77619]
xref: RHEA:77619
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:0160122
name: corneal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an corneal epithelial cell, any of the cells making up an corneal epithelium." [PMID:32697979, PMID:33414365]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0160123
name: structural constituent of nuclear lamina
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of nuclear lamina." [PMID:2824113, PMID:31434876]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0160124
name: guanyl nucleotide exchange factor activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a guanyl nucleotide exchange factor." [PMID:37463208]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0160125
name: pH-gated sodium channel activity
namespace: molecular_function
def: "A gated channel activity that enables the transmembrane transfer of a sodium ion by a channel that opens in response to a change in pH." [PMID:34767445]
synonym: "pH-dependent sodium channel activity" RELATED []
synonym: "pH-sensitive sodium channel activity" RELATED []
is_a: GO:0015280 ! ligand-gated sodium channel activity
is_a: GO:0160128 ! pH-gated monoatomic ion channel activity

[Term]
id: GO:0160126
name: pH-gated calcium channel activity
namespace: molecular_function
def: "A gated channel activity that enables the transmembrane transfer of a calcium ion by a channel that opens in response to a change in pH." [PMID:30930064, PMID:34767445]
synonym: "pH-dependent calcium channel activity" RELATED []
synonym: "pH-sensitive calcium channel activity" RELATED []
is_a: GO:0099604 ! ligand-gated calcium channel activity
is_a: GO:0160128 ! pH-gated monoatomic ion channel activity

[Term]
id: GO:0160127
name: protein-RNA covalent cross-linking repair
namespace: biological_process
def: "A process that rescues stalled ribosomes by removing the covalent cross-link between RNA and a protein." [PMID:37951215, PMID:37951216]
is_a: GO:0072344 ! rescue of stalled ribosome

[Term]
id: GO:0160128
name: pH-gated monoatomic ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH)." [PMID:17167423, PMID:29513651]
comment: While the term suggest this activity may be proton-gated, the mechanism of pH-gating for transporters is by protonation of specific residues in the protein, and not by H+ binding.
synonym: "acid-sensing ion channel activity" RELATED []
synonym: "proton-gated ion channel activity" EXACT []
xref: Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol"
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0160129
name: protein-DNA covalent cross-linking activity
namespace: molecular_function
def: "Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein." [PMID:30554877, PMID:31235913]
xref: MetaCyc:RXN-21016
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0160130
name: mRNA cap methyltransferase RNMT:RAMAC complex
namespace: cellular_component
def: "A protein complex that consists of RNA guanine-7 methyltransferase (RNMT) and RNA guanine-7 methyltransferase activating subunit (RAMAC) and is involved in mRNA cap methylation." [PMID:22099306]
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0160131
name: sperm migration through the uterotubal junction
namespace: biological_process
def: "The controlled self-propelled movement of a sperm cell from the uterus through the uterotubal junction (UTJ) into the oviduct, where interaction between the sperm and the UTJ acts as a major selective barrier for sperm, allowing only living, motile, uncapacitated, morphologically normal sperm with intact acrosomes to pass from the uterus into the oviduct." [GOC:krc, PMID:29353867, PMID:31131960, PMID:32712384, PMID:34057175]
synonym: "sperm migration from the uterus to the oviduct" EXACT []
synonym: "sperm migration through the UTJ" RELATED []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0160132
name: meisosome
namespace: cellular_component
def: "A cell part that is composed of multifold plasma membrane of the epidermis where it is in direct contact with apical extracellular matrix. Meisosome, or multiple eisome is named because of its superficial similarity to yeast eisosome." [PMID:36913486]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0160133
name: bicarbonate channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion of bicarbonate through a transmembrane aqueous pore or channel." [PMID:18400985]
synonym: "hydrogencarbonate channel activity" EXACT []
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0160134
name: protein-RNA sequence-specific adaptor activity
namespace: molecular_function
def: "A protein adaptor activity characterized by the capacity to selectively recognize and interact with RNA molecules in a sequence-specific manner. Entities possessing this activity typically exhibit discerning binding preferences for specific nucleotide sequences within RNA molecules, enabling the identification and engagement of distinct RNA motifs or structural elements. This function is integral to various biological processes, including RNA processing, transport, and regulatory mechanisms, contributing to the specificity and precision of cellular RNA-related activities." [PMID:14749727, PMID:17036044]
is_a: GO:0140517 ! protein-RNA adaptor activity

[Term]
id: GO:0160135
name: phospholipase C-activating endothelin receptor signaling pathway
namespace: biological_process
def: "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:35284927]
is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
is_a: GO:0086100 ! endothelin receptor signaling pathway

[Term]
id: GO:0160136
name: 16S rRNA pseudouridine(516) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA." [EC:5.4.99.19, RHEA:38867]
xref: EC:5.4.99.19
xref: RHEA:38867
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160137
name: 23S rRNA pseudouridine(2457) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA." [EC:5.4.99.20, RHEA:38871]
xref: EC:5.4.99.20
xref: RHEA:38871
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160138
name: 23S rRNA pseudouridine(2604) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA." [EC:5.4.99.21, RHEA:38875]
xref: EC:5.4.99.21
xref: RHEA:38875
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160139
name: 23S rRNA pseudouridine(2605) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA." [EC:5.4.99.22, RHEA:42520]
xref: EC:5.4.99.22
xref: RHEA:42520
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160140
name: 23S rRNA pseudouridine(1911/1915/1917) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA." [EC:5.4.99.23, RHEA:42524]
xref: EC:5.4.99.23
xref: RHEA:42524
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160141
name: 23S rRNA pseudouridine(955/2504/2580) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA." [EC:5.4.99.24, RHEA:42528]
xref: EC:5.4.99.24
xref: RHEA:42528
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160142
name: 23S rRNA pseudouridine(746) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA." [EC:5.4.99.29, RHEA:42548]
xref: EC:5.4.99.29
xref: RHEA:42548
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160143
name: 21S rRNA pseudouridine(2819) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA." [EC:5.4.99.43, RHEA:42556]
xref: EC:5.4.99.43
xref: RHEA:42556
is_a: GO:0120159 ! rRNA pseudouridine synthase activity

[Term]
id: GO:0160144
name: GDF15-GFRAL signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by GDF15 binding to GFRAL coreceptor, triggering RET autophosphorylation and activation, in response to stress." [PMID:30639358, PMID:31535977, PMID:33593916, PMID:37437602]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0160145
name: negative regulation of GDF15-GFRAL signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of GDF15-GFRAL signaling pathway." [PMID:35177851]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: negatively_regulates GO:0160144 ! GDF15-GFRAL signaling pathway

[Term]
id: GO:0160147
name: tRNA pseudouridine(38-40) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA." [EC:5.4.99.12]
synonym: "PSUI activity" EXACT [EC:5.4.99.12]
synonym: "tRNA pseudouridylate synthase" EXACT [EC:5.4.99.12]
xref: EC:5.4.99.12
xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN
xref: RHEA:22376
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160148
name: tRNA pseudouridine(55) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(55) in tRNA = pseudouridine(55) in tRNA." [EC:5.4.99.25]
xref: EC:5.4.99.25
xref: RHEA:42532
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160149
name: tRNA pseudouridine(65) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(65) in tRNA = pseudouridine(65) in tRNA." [EC:5.4.99.26]
xref: EC:5.4.99.26
xref: RHEA:42536
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160150
name: tRNA pseudouridine(13) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(13) in tRNA = pseudouridine(13) in tRNA." [EC:5.4.99.27]
xref: EC:5.4.99.27
xref: RHEA:42540
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160151
name: tRNA pseudouridine(32) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(32) in tRNA = pseudouridine(32) in tRNA." [EC:5.4.99.28]
xref: EC:5.4.99.28
xref: RHEA:42544
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160152
name: tRNA pseudouridine(31) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(31) in tRNA = pseudouridine(31) in tRNA." [EC:5.4.99.42]
xref: EC:5.4.99.42
xref: RHEA:42552
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160153
name: mitochondrial tRNA pseudouridine(27/28) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA." [EC:5.4.99.44]
xref: EC:5.4.99.44
xref: RHEA:42560
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160154
name: tRNA pseudouridine(38/39) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA." [EC:5.4.99.45]
xref: EC:5.4.99.45
xref: RHEA:42564
is_a: GO:0106029 ! tRNA pseudouridine synthase activity

[Term]
id: GO:0160155
name: crinophagy
namespace: biological_process
def: "The autophagic process which involves the direct fusion of abnormal, excess or obsolete secretory granules with lysosomes. This pathway is often associated with maintaining homeostasis in endocrine and exocrine cells." [PMID:29066608, PMID:35452619]
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0160156
name: secretory granule-lysosome fusion
namespace: biological_process
def: "The cellular process that results in the fusion of secretory granules with lysosomes to form crinosomes." [PMID:29066608, PMID:35452619]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0160155 ! crinophagy

[Term]
id: GO:0160157
name: branched-chain alpha-ketoacid dehydrogenase complex
namespace: cellular_component
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: branched-chain alpha-ketoacid dehydrogenase (E1, a heterotetramer of two alpha and two beta subunits), dihydrolipoyl transacylase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:10464218, PMID:10745006, PMID:3593587]
comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms '3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity ; GO:0003863' (E1), 'dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity ; GO:0043754' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'branched-chain alpha-keto acid dehydrogenase activity (GO:0047101)'.
synonym: "BCKD complex" EXACT []
synonym: "BKDH complex" EXACT []
xref: Wikipedia:Branched-chain_alpha-keto_acid_dehydrogenase_complex
is_a: GO:0045240 ! alpha-ketoacid dehydrogenase complex

[Term]
id: GO:0160158
name: obsolete cytosolic branched-chain alpha-keto acid dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. It is composed of four polypeptides, E1alpha, E1beta, E2, and E3." [PMID:10464218]
comment: This term is unnecessarily taxon-specific.
synonym: "BKDH complex" EXACT []
is_obsolete: true
replaced_by: GO:0160157

[Term]
id: GO:0160159
name: positive regulation of N-acetylmuramic acid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N-acetylmuramic acid catabolic process." [PMID:18723630]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0097173 ! N-acetylmuramic acid catabolic process

[Term]
id: GO:0160160
name: positive regulation of nicotine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nicotine catabolic process." [PMID:15838033]
is_a: GO:0009896 ! positive regulation of catabolic process
relationship: positively_regulates GO:0019608 ! nicotine catabolic process

[Term]
id: GO:0160161
name: positive regulation of propanediol catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of propanediol catabolic process." [PMID:7559322, PMID:9023178]
is_a: GO:1900421 ! positive regulation of alcohol catabolic process
relationship: positively_regulates GO:0051144 ! propanediol catabolic process

[Term]
id: GO:0160162
name: CD27 signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the cell surface receptor CD27 to its physiological ligand CD70, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:26359318, PMID:8387892]
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0160163
name: S-nitrosoglutathione reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione." [RHEA:63500]
xref: RHEA:63500
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0160164
name: negative regulation of chromatin looping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin looping." [PMID:34856126]
is_a: GO:1905268 ! negative regulation of chromatin organization
relationship: negatively_regulates GO:0140588 ! chromatin looping

[Term]
id: GO:0160165
name: CD8-positive, alpha-beta T cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of CD8-positive alpha-beta T cells such that the total number of CD8-positive alpha-beta T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:30650357, PMID:33815406]
synonym: "CD8+ T cell homeostasis" BROAD []
synonym: "CD8-positive T cell homeostasis" BROAD []
is_a: GO:0043029 ! T cell homeostasis

[Term]
id: GO:0160166
name: 2-oxoadipate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoadipate + H+ + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]." [PMID:29191460, PMID:32695416]
xref: RHEA:69576
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0160167
name: oxoadipate dehydrogenase complex
namespace: cellular_component
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of 2-oxoadipate to glutaryl-CoA, thereby acting in the final step of lysine and tryptophan catabolism in mitochondria. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: 2-oxoadipate dehydrogenase (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3)." [PMID:29191460, PMID:32695416]
comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms '2-oxoadipate dehydrogenase activity ; GO:0160166' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3).
synonym: "OADHC" EXACT []
is_a: GO:0045240 ! alpha-ketoacid dehydrogenase complex

[Term]
id: GO:0160168
name: T=9 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=9 symmetry. The T=9 capsid is composed of 12 pentameric and 80 hexameric capsomeres." [PMID:37138077]
xref: VZ:5316
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0160169
name: T=21/pseudo21 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=21 or pseudo T=21 symmetry." [VZ:833]
xref: VZ:833
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0160170
name: T=27/pseudo27 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=27 or pseudo T=27 symmetry." [VZ:1556]
xref: VZ:1556
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0160171
name: T=28 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=28 symmetry." [VZ:6057]
xref: VZ:6057
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0160172
name: T=31/pseudo31 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=31 or pseudo T=31 symmetry." [VZ:7036]
xref: VZ:7036
is_a: GO:0019030 ! icosahedral viral capsid

[Term]
id: GO:0160173
name: histamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of histamine from one side of a membrane to the other." [PMID:36288320]
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:0160174
name: cortical rotation
namespace: biological_process
def: "A cellular developmental process by which the outer layer of the cell (the cortex) rotates relative to the inner cytoplasm." [PMID:22949618, PMID:25077289, PMID:37983969]
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0160175
name: somatic muscle attachment to chitin-based cuticle
namespace: biological_process
def: "The developmental process in which a somatic muscle attaches to the chitin-based cuticle. In insects, this may occur via a specialized epithelial cell adherence to the chitinous extracellular matrix and to muscle cells through their basement membrane." [PMID:35675426]
is_a: GO:0007525 ! somatic muscle development

[Term]
id: GO:0160176
name: magnesium ion transport from cytosol to endoplasmic reticulum
namespace: biological_process
def: "The directed movement of magnesium ion from cytosol to endoplasmic reticulum." [PMID:38513662]
is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport
is_a: GO:1903830 ! magnesium ion transmembrane transport

[Term]
id: GO:0160177
name: positive regulation of autophagosome-lysosome fusion
namespace: biological_process
def: "Any process that activates or increases the rate which autophagosomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects)." [PMID:38360932]
is_a: GO:0031340 ! positive regulation of vesicle fusion
relationship: positively_regulates GO:0061909 ! autophagosome-lysosome fusion

[Term]
id: GO:0160178
name: dipeptide uniporter activity
namespace: molecular_function
def: "Catalysis of the transport of a dipeptide across a membrane; transport is independent of the movement of any other molecular species." [PMID:38507452]
is_a: GO:0015292 ! uniporter activity
is_a: GO:0071916 ! dipeptide transmembrane transporter activity

[Term]
id: GO:0160179
name: intestinal iron absorption
namespace: biological_process
def: "A process in which iron is taken up from the contents of the intestine." [PMID:16054062, PMID:17729393]
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0160181
name: piperine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of piperine." [PMID:33435446, PMID:33833371]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0160182
name: nitrate reductase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: a quinol + nitrate = a quinone + H2O + nitrite." [RHEA:56144]
synonym: "dissimilatory nitrate reductase" RELATED [EC:1.7.5.1]
synonym: "dissimilatory nitrate reductase activity" RELATED [EC:1.7.5.1]
synonym: "nitrate reductase A activity" RELATED [EC:1.7.5.1]
synonym: "nitrate reductase Z activity" RELATED [EC:1.7.5.1]
synonym: "quinol-nitrate oxidoreductase activity" RELATED [EC:1.7.5.1]
xref: EC:1.7.5.1
xref: RHEA:56144
is_a: GO:0008940 ! nitrate reductase activity

[Term]
id: GO:0160183
name: autophagosome-membrane adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a target membrane and an autophagosome during autophagy." [PMID:30544615, PMID:36635405]
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0160184
name: paracellular transport
namespace: biological_process
def: "The directed movement of substance through the space in between adjacent cells, rather than through the cells themselves." [PMID:28452575, WIki:Paracellular_transport]
is_a: GO:0006810 ! transport

[Term]
id: GO:0160185
name: phospholipase C activator activity
namespace: molecular_function
def: "Binds to and increases the activity of the enzyme phospholipase C." [PMID:28130414]
is_a: GO:0016004 ! phospholipase activator activity

[Term]
id: GO:0160186
name: phospholipase C inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of the enzyme phospholipase C." [PMID:28130414]
is_a: GO:0004859 ! phospholipase inhibitor activity

[Term]
id: GO:0160187
name: paracellular tight junction channel activity
namespace: molecular_function
def: "Enables size- and charge-selective transport of solutes through a tight junction barrier paracellularly, across the epithelium." [PMID:30665499]
synonym: "claudin pore" EXACT []
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0160188
name: obsolete sterol:proton antiporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a sterol from one side of a membrane to the other according to the reaction: H+(out) + sterol(in) = H+(in) + sterol(out)." [PMID:31543266]
comment: The reason for obsoletion is that this term was added in error.
is_obsolete: true

[Term]
id: GO:0160189
name: peroxisomal-mitochondrial contact site
namespace: cellular_component
def: "An organelle membrane contact site between peroxisomal membrane and mitochondrial outer membrane." [PMID:29684109, PMID:38669296]
synonym: "PerMit contact" EXACT []
synonym: "PerMit contact site" EXACT []
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0160190
name: peroxisome-mitochondrion membrane tether activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together the peroxisome and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion." [PMID:29720625, PMID:38669296]
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0160191
name: steroid 22S-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a C28-steroid + O2 + reduced NADPH--hemoprotein reductase = a (22S)-22-hydroxy C28-steroid + H+ + H2O + oxidized NADPH--hemoprotein reductase. Also catalyzes the C-22 hydroxylation of a variety of C27 and C29 steroids." [EC:1.14.14.178]
synonym: "steroid C-22 hydroxylase activity" EXACT [EC:1.14.14.178]
xref: EC:1.14.14.178
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0160192
name: autophagosome-dependent secretion
namespace: biological_process
def: "A process of exocytosis that uses the autophagy machinery to facilitate secretion of the cytosolic cargo such as leaderless cytosolic proteins which cannot enter the conventional secretory pathway operating via the endoplasmic reticulum and the Golgi apparatus." [PMID:25988755, PMID:38534758]
synonym: "autophagy-dependent secretion" EXACT []
synonym: "secretory autophagy" EXACT []
is_a: GO:0006887 ! exocytosis
is_a: GO:0051656 ! establishment of organelle localization
is_a: GO:0061906 ! autophagosome localization

[Term]
id: GO:0160193
name: L-lactate dehydrogenase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of L-lactate dehydrogenase." [PMID:33406399]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0160194
name: stereocilium bundle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a sensory hair cell stereocilium bundle." [PMID:28266911, PMID:6978627]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0160195
name: negative regulation of phospholipase C/protein kinase C signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C/protein kinase C signal transduction." [PMID:32033984]
synonym: "negative regulation of PLC/PKC signal transduction" EXACT []
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0141212 ! phospholipase C/protein kinase C signal transduction

[Term]
id: GO:0160196
name: polyprenol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ditrans,polycis-polyprenol + NAD(P) = ditrans,polycis-polyprenal+ NAD(P)H + H+." [PMID:38821050]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0160197
name: dolichal reductase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: a di-trans,poly-cis-dolichal+ H+ + NAD(P)+ = a di-trans,poly-cis-dolichal + NAD(P)H." [PMID:38821050]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0160198
name: polyprenal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ditrans,polycis-polyprenal+ H+ + NADPH = ditrans,polycis-dolichal+ NADP." [PMID:38821050, RHEA:80727]
xref: EC:1.3.1.94
xref: MetaCyc:RXN-9971
xref: RHEA:80727
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0160199
name: positive regulation of 7-methylguanosine mRNA capping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 7-methylguanosine mRNA capping." [PMID:19328067]
is_a: GO:0050685 ! positive regulation of mRNA processing
relationship: positively_regulates GO:0006370 ! 7-methylguanosine mRNA capping

[Term]
id: GO:0160201
name: polaroplast
namespace: cellular_component
def: "A membrane-bounded organelle found in a microsporidian spore,  that swells with water, and exerts pressure to rupture the polar cap and evert the polar tube through which the sporoplasm escapes to infect the host." [PMID:16005007, PMID:19673893, Wikipedia:polaroplast]
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0160202
name: polar tube anchoring disc
namespace: cellular_component
def: "A structural component of the microsporidian spore's invasion apparatus that is located at the anterior end of the spore and serves to attach the polar tube to the inside of the spore wall." [PMID:16005007, PMID:19673893]
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0160203
name: mitochondrial disulfide relay system
namespace: biological_process
def: "A protein folding process that facilitates the import of a subset of soluble proteins into mitochondrial intermembrane space via disulfide bond formation." [PMID:32936885, PMID:37159021]
synonym: "MIA pathway" EXACT []
synonym: "mitochondrial intermembrane space assembly pathway" EXACT []
is_a: GO:0006457 ! protein folding
relationship: part_of GO:0045041 ! protein import into mitochondrial intermembrane space

[Term]
id: GO:0160204
name: mitochondrion-mitochondrion outer membrane tether activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two mitochondrion membranes via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:38843396]
synonym: "mitochondrion membrane tether activity" RELATED []
synonym: "mitochondrion outer membrane tether activity" RELATED []
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0160205
name: cysteine-dependent adenosine diphosphate thiazole synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide." [RHEA:55708]
synonym: "ADP-thiazole synthase activity" RELATED [EC:2.4.2.60]
synonym: "suicide thiamine thiazole synthase activity" EXACT []
xref: EC:2.4.2.60
xref: RHEA:55708
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:0160206
name: tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytidine(32)/uridine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methyluridine(32) in tRNA + H+ + S-adenosyl-L-homocysteine." [EC:2.1.1.200]
synonym: "TrMet(Xm32) activity" EXACT []
xref: EC:2.1.1.200
is_a: GO:0016300 ! tRNA (uridine) methyltransferase activity
is_a: GO:0016427 ! tRNA (cytidine) methyltransferase activity

[Term]
id: GO:0160207
name: positive regulation of androgen receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androgen receptor signaling." [PMID:29057879]
is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0060765 ! regulation of androgen receptor signaling pathway
relationship: positively_regulates GO:0030521 ! androgen receptor signaling pathway

[Term]
id: GO:0160208
name: fibrous body-membranous organelle
namespace: cellular_component
def: "A Golgi-derived organelle that forms in primary spermatocytes during spermatogenesis of some nematodes including C. elegans. This 'double organelle' consists of a fibrous body containing major sperm protein and a membranous organelle that envelops the developing fibrous body." [PMID:18050478, PMID:8004009]
synonym: "FB-MO" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0160209
name: FMRP-CYFIP1 complex
namespace: cellular_component
def: "A protein-containing complex that contains the fragile X mental retardation protein (FMRP) and cytoplasmic FMRP Interacting protein 1 (CYIFIP1), and is capable of inhibiting translation initiation by binding to the eIF4F complex." [PMID:18805096, PMID:28183735]
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:0160210
name: L-serine O-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + succinyl-CoA = CoA + O-succinyl-L-serine." [PMID:28581482, RHEA:52820]
xref: RHEA:52820
is_a: GO:0016750 ! O-succinyltransferase activity

[Term]
id: GO:0160211
name: apicoplast membrane
namespace: cellular_component
def: "Any of the lipid bilayers that surround an apicoplast and form the apicoplast envelope." [PMID:20124342, PMID:38865262]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0020011 ! apicoplast

[Term]
id: GO:0160212
name: glycine-gated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [PMID:11823786]
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity

[Term]
id: GO:0160213
name: beta-arrestin-dependent dopamine receptor signaling pathway
namespace: biological_process
def: "A beta-arrestin-dependent signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [PMID:21711983, PMID:25671228]
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:1903351 ! cellular response to dopamine

[Term]
id: GO:0160214
name: endoplasmic reticulum-plasma membrane adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a plasma membrane with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication." [PMID:23041194, PMID:39239853]
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0160215
name: deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CO-X + H2O = R-COOH + HX, hydrolysis of an acyl group or groups from a substrate molecule." [PMID:2760018, PMID:29637793, PMID:38355760]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0160216
name: protein lysine delactylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] = (S)-lactate + L-lysyl-[protein]." [PMID:35044827]
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0160215 ! deacylase activity

[Term]
id: GO:0160217
name: negative regulation of transcription initiation-coupled chromatin remodeling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription initiation-coupled chromatin remodeling." [PMID:33980486]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1905268 ! negative regulation of chromatin organization
relationship: negatively_regulates GO:0045815 ! transcription initiation-coupled chromatin remodeling

[Term]
id: GO:0160218
name: negative regulation of acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [PMID:26942675, PMID:36849569, PMID:37754565]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010510 ! regulation of acetyl-CoA biosynthetic process from pyruvate
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate

[Term]
id: GO:0160219
name: cortical endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the cortical endoplasmic reticulum." [PMID:32735772]
is_a: GO:0098826 ! endoplasmic reticulum tubular network membrane
relationship: part_of GO:0032541 ! cortical endoplasmic reticulum

[Term]
id: GO:0160220
name: D-alanine-(R)-lactate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate." [RHEA:37347]
synonym: "D-alanyl-D-lactate ligase activity" EXACT []
xref: EC:6.1.2.1
xref: KEGG_REACTION:R09588
xref: MetaCyc:RXN-11298
xref: RHEA:37347
is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds

[Term]
id: GO:0160221
name: Rho-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of Rho activity. Rho is a family of small (~21 kDa) signaling G proteins that include RhoA, Cdc42, and Rac1." [PMID:10836144, PMID:33849392]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0160222
name: D-alanine-D-serine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H+ + phosphate." [EC:6.3.2.35, RHEA:27706]
xref: EC:6.3.2.35
xref: KEGG_REACTION:R09595
xref: MetaCyc:RXN-11299
xref: RHEA:27706
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0160223
name: pyrenoid tubule
namespace: cellular_component
def: "A specialized membranous structure that extends from the photosynthetic thylakoid membrane into and transverses the matrix of a pyrenoid." [PMID:32428480]
synonym: "thylakoid membrane tubule" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:1990732 ! pyrenoid

[Term]
id: GO:0160224
name: 3-demethoxyubiquinone 3-hydroxylase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone + NADH + O2 = a 3-demethylubiquinone + NAD+ + H2O." [PMID:23445365, PMID:38425362]
synonym: "5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone,NADH:oxygen oxidoreductase (5-hydroxylating) activity" EXACT []
xref: EC:1.14.13.253
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0170001
name: ergothioneine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ergothioneine from one side of a membrane to the other." [PMID:15795384, PMID:20601551, PMID:29530864]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0170002
name: halotropism
namespace: biological_process
def: "A sodium-specific negative tropism that is crucial for surviving and thriving under high salinity." [PMID:36243013]
synonym: "root halotropism" EXACT []
is_a: GO:0009606 ! tropism

[Term]
id: GO:0170003
name: heme B transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of heme B from one side of a membrane to the other." [PMID:15369674, PMID:20610401, PMID:32121449, PMID:9657107]
is_a: GO:0015232 ! heme transmembrane transporter activity

[Term]
id: GO:0170004
name: lipoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lipoate from one side of a membrane to the other." [PMID:20980265, PMID:25971966]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0170005
name: cyclic nucleotide phosphodiesterase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of cyclic nucleotide phosphodiesterase." [PMID:6087882, PMID:6259174, PMID:6667031]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0170006
name: lipoate transmembrane transport
namespace: biological_process
def: "The process in which lipoate is transported across a membrane." [PMID:20980265, PMID:25971966]
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0170007
name: endoplasmic reticulum-lipid droplet tether activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a lipid droplet with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication." [PMID:35389430]
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0170008
name: mRNA phosphatase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of mRNA phosphatase." [PMID:22323607]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0170009
name: endoplasmic reticulum-organelle membrane tether activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain membrane contact sites and mediate organelle exchange and communication." [PMID:29858488]
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:0170010
name: nonsense-mediated decay complex
namespace: cellular_component
def: "A highly conserved protein complex that recognises and elicits the rapid degradation of mRNAs in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:lnp, PMID:1569946, PMID:29282598, PMID:9032286]
synonym: "Upf complex" EXACT []
xref: IntAct:EBI-16420380
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0170011
name: stalled ribosome sensor activity
namespace: molecular_function
def: "A molecule that recognizes stalled ribosomes and initiates a signaling response." [PMID:32289254, PMID:32610081, PMID:36638793]
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0170012
name: histone H3K18 decrotonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide." [PMID:34927582]
is_a: GO:0160012 ! NAD-dependent histone decrotonylase activity

[Term]
id: GO:0170013
name: channel complex
namespace: cellular_component
def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [PMID:10839820]
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0170014
name: ankyrin-1 complex
namespace: cellular_component
def: "A complex composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1, that functions in the stability and shape of the erythrocyte membrane in human." [PMID:35835865]
synonym: "ankyrin complex" EXACT []
synonym: "erythrocyte ankyrin-1 complex" EXACT []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0170015
name: carbon dioxide receptor activity
namespace: molecular_function
def: "Combining with carbon dioxide to initiate a change in cell activity." [PMID:24240097]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0170016
name: endoplasmic reticulum-endosome tether activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange." [PMID:33124732]
is_a: GO:0170009 ! endoplasmic reticulum-organelle membrane tether activity

[Term]
id: GO:0170020
name: ionotropic olfactory receptor activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific odorant has been bound by the channel complex or one of its constituent parts." [PMID:21857978, PMID:24661599]
is_a: GO:0004984 ! olfactory receptor activity
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0170021
name: ionotropic taste receptor activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a soluble compound has been bound by the channel complex or one of its constituent parts." [PMID:36828965]
is_a: GO:0008527 ! taste receptor activity
is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity

[Term]
id: GO:0170022
name: ionotropic bitter taste receptor activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific bitter compound has been bound by the channel complex or one of its constituent parts." [PMID:21262465]
is_a: GO:0170021 ! ionotropic taste receptor activity

[Term]
id: GO:0170023
name: ionotropic sweet taste receptor activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific soluble sweet compound has been bound by the channel complex or one of its constituent parts." [PMID:24474785]
is_a: GO:0170021 ! ionotropic taste receptor activity

[Term]
id: GO:0170027
name: SKA complex
namespace: cellular_component
def: "An outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis. In humans, it contains the subunits SKA1, SKA2 and SKA3." [PMID:19289083, PMID:22483620]
synonym: "SKA1 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000940 ! outer kinetochore

[Term]
id: GO:0170033
name: L-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an L-amino acid." [GOC:edw]
synonym: "L-alpha-amino acid metabolism" EXACT []
synonym: "L-amino acid metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0170034
name: L-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw]
synonym: "L-amino acid anabolism" EXACT []
synonym: "L-amino acid biosynthesis" EXACT []
synonym: "L-amino acid formation" EXACT []
synonym: "L-amino acid synthesis" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0170035
name: L-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an L-amino acid." [GOC:edw]
synonym: "L-amino acid breakdown" EXACT []
synonym: "L-amino acid catabolism" EXACT []
synonym: "L-amino acid degradation" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0170036
name: import into the mitochondrion
namespace: biological_process
def: "The directed movement of substances from the cytosol into the mitochondrion." [GOC:ew]
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0170037
name: export from the mitochondrion
namespace: biological_process
def: "The directed movement of substances from the mitochondrion to the cytosol." [GOC:ew]
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0170038
name: proteinogenic amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew]
synonym: "proteinogenic amino acid anabolism" EXACT []
synonym: "proteinogenic amino acid biosynthesis" EXACT []
synonym: "proteinogenic amino acid formation" EXACT []
synonym: "proteinogenic amino acid synthesis" EXACT []
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0170039
name: proteinogenic amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew]
synonym: "proteinogenic amino acid metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0170040
name: proteinogenic amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew]
synonym: "proteinogenic amino acid breakdown" EXACT []
synonym: "proteinogenic amino acid catabolism" EXACT []
synonym: "proteinogenic amino acid degradation" EXACT []
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:0170041
name: non-proteinogenic amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving non-proteingenic amino acids." [GOC:ew]
synonym: "non-proteinogenic amino acid metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0170043
name: non-proteinogenic amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids." [GOC:ew]
synonym: "non-proteinogenic amino acid anabolism" EXACT []
synonym: "non-proteinogenic amino acid formation" EXACT []
synonym: "non-proteinogenic amino acid synthesis" EXACT []
synonym: "non-proteinogenic biosynthesis" EXACT []
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0170044
name: non-proteinogenic amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids." [GOC:ew]
synonym: "non-proteinogenic amino acid breakdown" EXACT []
synonym: "non-proteinogenic amino acid catabolism" EXACT []
synonym: "non-proteinogenic amino acid degradation" EXACT []
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:0170045
name: isopentenyl pyrophosphate transmembrate transporter activity
namespace: molecular_function
def: "Enables the transfer of isopentenyl pyrophosphate from one side of a membrane to the other." [GOC:ew, PMID:37813972]
synonym: "IPP transmembrane transport activity" EXACT []
synonym: "isopentenyl diphosphate transmembrane transport activity" EXACT []
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:0170046
name: isopentenyl pyrophosphate import into mitochondrion
namespace: biological_process
def: "The process in which isopentenyl pyrophosphate is transported across a membrane into the mitochondrion." [GOC:ew, PMID:37813972]
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0170047
name: virus-like capsid
namespace: cellular_component
def: "A protein coat that surrounds nucleic acid to form a structure similar to a virus capsid. Virus-like capsids are non-infectious and are encoded by endogenous (non-viral) genes. Fly and tetrapod Arc (ancestrally-related to retrotransposon Gag) are examples of proteins that can self-assemble into capsid-like structures which encapsulate Arc mRNA and mediate the intercellular transmission of RNA." [PMID:29328916]
synonym: "virus-like particle" NARROW []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0170048
name: D-alanine import across plasma membrane
namespace: biological_process
def: "The directed import of D-alanine from the extracellular region across the plasma membrane and into the cytosol." [PMID:22418438, PMID:25425233]
synonym: "D-alanine import" BROAD []
synonym: "D-alanine import into cell" EXACT []
synonym: "D-alanine uptake" EXACT []
is_a: GO:0042941 ! D-alanine transmembrane transport

[Term]
id: GO:0170049
name: box C/D RNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex consisting of a box C/D type snRNA and three (Archaea) or four (Eukaryotes) core proteins that have diverse functions, including site-specific methylation of rRNA and processing rRNA." [PMID:28505386, PMID:30254138]
synonym: "SNORD ribonucleoprotein complex" BROAD []
synonym: "SNORNP" BROAD []
is_a: GO:0005732 ! sno(s)RNA-containing ribonucleoprotein complex

[Term]
id: GO:0170050
name: box C/D methylation guide RNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing a box C/D type snoRNA and three (Archaea) or four (Eukaryotes) core proteins that is capable of methylation of target RNAs." [PMID:28505386, PMID:30254138]
is_a: GO:0170049 ! box C/D RNP complex

[Term]
id: GO:0170051
name: box C/D methylation guide scaRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing a small CB-specific RNA (scaRNA), with a short sequence motif (GU/UG wobble stem) for CB localization that is capable of methylation of target RNAs." [PMID:27775477]
is_a: GO:0170049 ! box C/D RNP complex

[Term]
id: GO:0170052
name: box C/D pre-rRNA cleavage RNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing a box C/D type RNA that is involved in pre-rRNA cleavage." [PMID:15367679, PMID:28505386, PMID:30254138]
is_a: GO:0170049 ! box C/D RNP complex

[Term]
id: GO:0170053
name: nuclease activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a nuclease." [PMID:24736845]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0170054
name: ribonuclease activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a ribonuclease." [PMID:24736845]
synonym: "RNA nuclease activator activity" EXACT []
is_a: GO:0170053 ! nuclease activator activity

[Term]
id: GO:0170055
name: lipid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a lipid from one side of a membrane to the other." [GOC:curators]
subset: gocheck_do_not_annotate
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0170056
name: cholesterol 7-desaturase (NAD(P)H) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + H+ + NAD(P)H + O2 = 7-dehydrocholesterol + 2 H2O + NAD(P)+." [PMID:21632547, PMID:31521708, RHEA:51644]
synonym: "C-7 cholesterol dehydrogenase" EXACT []
synonym: "cholesterol 7,8-dehydrogenase" EXACT []
xref: EC:1.14.19.21
xref: MetaCyc:RXN-16379
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0170057
name: RNA ligase (GTP) activity
namespace: molecular_function
def: "Catalysis of the joining of an RNA with 3'-phosphate or 2',3'-cyclic-phosphate ends to an RNA with 5'-hydroxy ends according to either (i) a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP; or (ii) a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H+." [EC:6.5.1.8, PMID:21311021]
synonym: "3'-phosphate/5'-hydroxy nucleic acid ligase activity" EXACT []
xref: EC:6.5.1.8
is_a: GO:0008452 ! RNA ligase activity

[Term]
id: GO:0170060
name: microtubule destablizing activity
namespace: molecular_function
def: "A protein-containing complex destabilizing activity that promotes microtubule catastrophe (transition from microtubule growth to microtubule shrinkage)." [PMID:29858272, PMID:36435910]
synonym: "microtubule catastrophe inducing activity" BROAD []
synonym: "microtubule catastrophe promoting activity" BROAD []
is_a: GO:0140776 ! protein-containing complex destabilizing activity

[Term]
id: GO:0170061
name: nickel chaperone activity
namespace: molecular_function
def: "Directly binding to and delivering nickel ions to a target protein." [PMID:32133383, PMID:34530332]
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0180000
name: histone methyltransferase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a histone methyltransferase." [PMID:30923826]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0180001
name: cyclic-di-AMP binding
namespace: molecular_function
def: "Binding to a cyclic di-AMP nucleotide." [PMID:32843560, PMID:36629470]
synonym: "cyclic dimeric adenosine monophosphate binding" EXACT []
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032559 ! adenyl ribonucleotide binding

[Term]
id: GO:0180002
name: renal zinc excretion
namespace: biological_process
def: "The elimination of zinc ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [PMID:28196538]
synonym: "renal zinc ion excretion" EXACT []
synonym: "renal zinc secretion" EXACT []
is_a: GO:0097254 ! renal tubular secretion

[Term]
id: GO:0180003
name: S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)." [PMID:14674884, PMID:34375635]
xref: RHEA:75479
is_a: GO:0000095 ! S-adenosyl-L-methionine transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:0180004
name: RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]
synonym: "RNA polymerase II C-terminal domain Y1 phosphatase activity" EXACT []
is_a: GO:0008420 ! RNA polymerase II CTD heptapeptide repeat phosphatase activity

[Term]
id: GO:0180005
name: RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-threonine (consensus YSPTSPS)(position 4) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]
synonym: "RNA polymerase II C-terminal domain T4 phosphatase activity" EXACT []
is_a: GO:0008420 ! RNA polymerase II CTD heptapeptide repeat phosphatase activity

[Term]
id: GO:0180006
name: RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]
synonym: "RNA polymerase II C-terminal domain S2 phosphatase activity" EXACT []
is_a: GO:0008420 ! RNA polymerase II CTD heptapeptide repeat phosphatase activity

[Term]
id: GO:0180007
name: RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]
synonym: "RNA polymerase II C-terminal domain S5 phosphatase activity" EXACT []
is_a: GO:0008420 ! RNA polymerase II CTD heptapeptide repeat phosphatase activity

[Term]
id: GO:0180008
name: RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]
synonym: "RNA polymerase II C-terminal domain S7 phosphatase activity" EXACT []
is_a: GO:0008420 ! RNA polymerase II CTD heptapeptide repeat phosphatase activity

[Term]
id: GO:0180009
name: broad specificity neutral L-amino acid:basic L-amino acid antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out)." [PMID:23506863, PMID:8663357]
synonym: "neutral L-amino acid:cationic L-amino acid antiporter activity" EXACT []
synonym: "neutral L-amino acid:dibasic L-amino acid antiporter activity" EXACT []
synonym: "neutral L-amino acid:positively-charged polar L-amino acid antiporter activity" EXACT []
synonym: "system b(0,+)-type activity" RELATED []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0180010
name: co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
namespace: biological_process
def: "Any process involved in transcription termination-coupled 3' processing of RNA polymerase II mRNA transcripts by the 3' end cleavage and addition of a poly(A) tail." [PMID:31499460]
synonym: "cotranscriptional 3' processing of RNA polymerase II mRNA transcripts" EXACT []
synonym: "mRNA polyadenylation" RELATED []
is_a: GO:0031124 ! mRNA 3'-end processing
is_a: GO:0180012 ! co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway

[Term]
id: GO:0180011
name: cytosolic mRNA polyadenylation
namespace: biological_process
def: "Any process by which dormant, translationally inactive mRNAs become activated, or mRNAs become stabilized, via the elongation of their poly(A) tails in the cytosol." [PMID:21536428]
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0180012
name: co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway
namespace: biological_process
def: "Any process involved in transcription termination-coupled 3' processing of RNA polymerase II RNA transcripts by 3' end cleavage and addition of a poly(A) tail." [PMID:31499460]
synonym: "cotranscriptional 3'-end processing of RNA polymerase II transcripts" EXACT []
xref: PMID:31499460
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0180013
name: lysophosphatidylserine flippase activity
namespace: molecular_function
def: "Catalysis of the movement of a lysophosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP." [PMID:34645814]
is_a: GO:0140333 ! glycerophospholipid flippase activity

[Term]
id: GO:0180014
name: protein-tRNA adaptor activity
namespace: molecular_function
def: "The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way." [PMID:31048492]
synonym: "tRNA carrier" RELATED []
is_a: GO:0140517 ! protein-RNA adaptor activity

[Term]
id: GO:0180015
name: nucleoside import across plasma membrane
namespace: biological_process
def: "The directed movement of nucleoside from outside of a cell, across the plasma membrane and into the cytosol." [PMID:21998139, PMID:30658162]
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1901642 ! nucleoside transmembrane transport

[Term]
id: GO:0180016
name: SUMO ligase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of a SUMO ligase." [PMID:19363481, PMID:33446573]
is_a: GO:0055103 ! ligase regulator activity

[Term]
id: GO:0180017
name: K11-linked deubiquitinase activity
namespace: molecular_function
def: "Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin." [PMID:26412298]
is_a: GO:0101005 ! deubiquitinase activity

[Term]
id: GO:0180018
name: cytoplasmic polyadenylation-dependent RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate." [PMID:20368444]
is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process

[Term]
id: GO:0180019
name: Knl1/Spc105 complex
namespace: cellular_component
def: "A kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans and yeast respectively, it consists of KNL1/Spc105p and ZWINT/Kre28p." [PMID:27881301]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000940 ! outer kinetochore

[Term]
id: GO:0180020
name: membrane bending activity
namespace: molecular_function
def: "The activity of bending or deforming a membrane. This activity can occur by multiple mechanisms including the insertion amphipathic domains into one or both leaflets." [PMID:19780639]
synonym: "membrane curving" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0180021
name: U6 snRNA 2'-O-ribose methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + U6 snRNA = S-adenosyl-L-homocysteine + U6 containing a 3'-terminal 2'-O-methylnucleotide + H+." [PMID:37403782, RHEA:63088]
xref: RHEA:63088
is_a: GO:0090486 ! small RNA 2'-O-methyltransferase activity

[Term]
id: GO:0180022
name: RQC-trigger complex
namespace: cellular_component
def: "A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B." [PMID:12077347, PMID:28757607, PMID:32099016]
synonym: "activating signal cointegrator 1 complex" EXACT []
synonym: "ASC-1 complex" EXACT [PMID:12077347]
synonym: "RQT complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0180023
name: cytosolic large ribosomal subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cytosolic large ribosomal subunit." [PMID:30467428]
is_a: GO:0000027 ! ribosomal large subunit assembly
relationship: part_of GO:0042256 ! cytosolic ribosome assembly

[Term]
id: GO:0180024
name: membrane grommet activity
namespace: molecular_function
def: "An activity in which a protein, or group of proteins, acts to restrict the size of a fenestration in a membrane or membrane system (i.e. restrict the diameter of a hole in a membrane). An example of this is the molecular function is performed by ESCRT-III proteins at the nuclear envelope of fission yeast during anaphase B." [PMID:37783794]
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0180025
name: cytosolic small ribosomal subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cytosolic small ribosomal subunit." [PMID:30467428]
is_a: GO:0000028 ! ribosomal small subunit assembly
relationship: part_of GO:0042256 ! cytosolic ribosome assembly

[Term]
id: GO:0180026
name: mitochondrial small ribosomal subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial small ribosomal subunit." [PMID:30467428]
is_a: GO:0000028 ! ribosomal small subunit assembly
relationship: part_of GO:0061668 ! mitochondrial ribosome assembly

[Term]
id: GO:0180027
name: inner nuclear membrane-associated protein degradation pathway
namespace: biological_process
def: "A protein quality control pathway that removes ubiquitinated proteins from the nuclear inner membrane before transferring them to the proteasome for degradation." [PMID:37694715]
synonym: "INMAD pathway" EXACT []
is_a: GO:0071630 ! nuclear protein quality control by the ubiquitin-proteasome system

[Term]
id: GO:0180028
name: mitotic spindle pole body attachment site
namespace: cellular_component
def: "A region of the nuclear envelope to which a spindle pole body (SPB) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [PMID:37783794]
is_a: GO:0034992 ! microtubule organizing center attachment site

[Term]
id: GO:0180029
name: phosphate ion export across plasma membrane
namespace: biological_process
def: "The directed movement of phosphate ions (Pi) from inside of a cell, across the plasma membrane and into the extracellular region." [PMID:37949217]
is_a: GO:0035435 ! phosphate ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:0180030
name: inositol phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol phosphate + ATP = inositol phosphate + ADP." [PMID:35536002]
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0180031
name: snoRNA 2,2,7-trimethylguanosine (TMG) capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5' end of an snoRNA. The snoRNA capping includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed snoRNAs are also TMG capped." [GOC:vw, PMID:15590684]
synonym: "snoRNA 2,2,7-trimethylguanosine (TMG) cap formation" EXACT []
synonym: "snoRNA capping" EXACT []
is_a: GO:0036260 ! RNA capping
is_a: GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:0180032
name: histone H4K5 deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 5) + H2O = histone H4 L-lysine (position 5) + acetate. This reaction represents the removal of an acetyl group from lysine at position 5 of the histone H4 protein." [PMID:37459529]
synonym: "histone H4K5 deacetylase activity" BROAD []
is_a: GO:0141051 ! histone H4K deacetylase activity

[Term]
id: GO:0180033
name: histone H4K8 deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 8) + H2O = histone H4 L-lysine (position 8) + acetate. This reaction represents the removal of an acetyl group from lysine at position 8 of the histone H4 protein." [PMID:37459529]
synonym: "histone H4K48 deacetylase activity" BROAD []
is_a: GO:0141051 ! histone H4K deacetylase activity

[Term]
id: GO:0180034
name: co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway
namespace: biological_process
def: "Any process involved in transcription termination-coupled 3' processing of RNA polymerase II lncRNA transcripts by the 3' end cleavage and addition of a poly(A) tail." [PMID:31276588]
synonym: "lncRNA 3' end processing" BROAD []
synonym: "lncRNA 3'-end processing" BROAD []
is_a: GO:0180012 ! co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway
is_a: GO:0180035 ! lncRNA processing

[Term]
id: GO:0180035
name: lncRNA processing
namespace: biological_process
def: "Any process involved in the conversion of one or more primary lncRNA transcripts into one or more mature lncRNA molecules." [PMID:31276588]
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0180036
name: nuclear lncRNA surveillance
namespace: biological_process
def: "A process that identifies and degrades defective or aberrant lncRNAs within the nucleus." [GOC:vw]
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0180037
name: rapid tRNA decay
namespace: biological_process
def: "A cytoplasmic tRNA surveillance pathway that targets mature hypomodified tRNAs, catalyzed by 5'-3' exonucleases Xrn1 (S. cerevisiae/human) and Rat1 (S. cerevisiae) XRN2 human, and regulated by adenosine 3',5' bisphosphate (pAp)." [GOC:vw, PMID:35901126]
is_a: GO:0106354 ! tRNA surveillance

[Term]
id: GO:0180038
name: cyclin L-CDK11 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin L and cyclin-dependent kinase 11 (CDK11). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:23122962, PMID:32446654]
synonym: "Cdk11-Cyclin L complex" EXACT []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0180039
name: regulation of pheromone response MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a pheromone response MAPK cascade." [GOC:vw]
is_a: GO:0043408 ! regulation of MAPK cascade
relationship: regulates GO:0071507 ! pheromone response MAPK cascade

[Term]
id: GO:0180040
name: negative regulation of pheromone response MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a pheromone response MAPK cascade." [GOC:vw]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0180039 ! regulation of pheromone response MAPK cascade
relationship: negatively_regulates GO:0071507 ! pheromone response MAPK cascade

[Term]
id: GO:0180041
name: glycolipid 1,4-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->4)-D-mannosyl-D-mannose linkage." [PMID:11226175, PMID:15635094]
synonym: "glycosylphosphatidylinositol-mannosyltransferase I" EXACT []
synonym: "GPI-MT-I activity" EXACT []
is_a: GO:0004376 ! glycolipid mannosyltransferase activity
is_a: GO:0051751 ! alpha-1,4-mannosyltransferase activity

[Term]
id: GO:0180042
name: polyphosphate import into vacuole
namespace: biological_process
def: "The directed movement of polyphosphate into the vacuole across the vacuolar membrane." [PMID:37066886]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:0180043
name: inositol pyrophosphate sensor activity
namespace: molecular_function
def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of an inositol pyrophosphate." [PMID:37949217]
is_a: GO:0140299 ! molecular sensor activity

[Term]
id: GO:0180044
name: borate channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of borate (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [PMID:21710975]
comment: https://github.com/geneontology/go-ontology/issues/27487
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0180045
name: type 1 mitophagy
namespace: biological_process
def: "The selective autophagy process in which a functional mitochondrion is degraded by macroautophagy to provide metabolic precursors during nutrient deprivation or to remove mitochondria in excess of metabolic needs." [GOC:vw, PMID:25009776]
is_a: GO:0000423 ! mitophagy

[Term]
id: GO:0180046
name: GPI anchored protein biosynthesis
namespace: biological_process
def: "Any process leading to the post-translational modification of a protein with a GPI anchor to achieve full functional capacity of the protein." [GOC:vw]
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0180047
name: dolichol phosphate mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichol phosphate mannose." [PMID:18387370]
synonym: "Dol-P-Man biosynthesis" EXACT []
synonym: "dolichol phosphate mannose biosynthesis" EXACT []
synonym: "dolichol-P-mannose biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0180048
name: phosphatidylinositol 4-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol 4-phosphate." [PMID:39239853]
synonym: "1-phosphatidyl-1D-myo-inositol 4-phosphate biosynthesis" EXACT []
synonym: "1-phosphatidyl-1D-myo-inositol biosynthetic process" EXACT []
synonym: "phosphatidylinositol (PI)-4- phosphate biosynthetic process" EXACT []
synonym: "phosphatidylinositol-4-phosphate synthesis" EXACT []
synonym: "PI4P biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0198738
name: obsolete cell-cell signaling by wnt
namespace: biological_process
def: "OBSOLETE. Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the receiving cell." [GOC:dos]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true
replaced_by: GO:0007166

[Term]
id: GO:1900000
name: regulation of anthocyanin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie]
synonym: "regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
relationship: regulates GO:0046284 ! anthocyanin-containing compound catabolic process

[Term]
id: GO:1900001
name: negative regulation of anthocyanin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie]
synonym: "down regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process
is_a: GO:1900000 ! regulation of anthocyanin catabolic process
relationship: negatively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process

[Term]
id: GO:1900002
name: positive regulation of anthocyanin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie]
synonym: "positive regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process
is_a: GO:1900000 ! regulation of anthocyanin catabolic process
relationship: positively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process

[Term]
id: GO:1900003
name: regulation of serine-type endopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
is_a: GO:0052548 ! regulation of endopeptidase activity
is_a: GO:1902571 ! regulation of serine-type peptidase activity

[Term]
id: GO:1900004
name: negative regulation of serine-type endopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
synonym: "down regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:1900003 ! regulation of serine-type endopeptidase activity
is_a: GO:1902572 ! negative regulation of serine-type peptidase activity

[Term]
id: GO:1900005
name: positive regulation of serine-type endopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:1900003 ! regulation of serine-type endopeptidase activity
is_a: GO:1902573 ! positive regulation of serine-type peptidase activity

[Term]
id: GO:1900006
name: positive regulation of dendrite development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite development." [GOC:TermGenie]
synonym: "up regulation of dendrite development" RELATED [GOC:TermGenie]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0050773 ! regulation of dendrite development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0016358 ! dendrite development

[Term]
id: GO:1900007
name: obsolete regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900008
name: obsolete negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "down regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie]
synonym: "down regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "negative regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900009
name: obsolete positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "positive regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900010
name: regulation of corticotropin-releasing hormone receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674]
subset: gocheck_obsoletion_candidate
synonym: "regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of CRH receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of signaling receptor activity

[Term]
id: GO:1900011
name: negative regulation of corticotropin-releasing hormone receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie]
synonym: "down regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CRH receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CRH receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity
is_a: GO:2000272 ! negative regulation of signaling receptor activity

[Term]
id: GO:1900012
name: obsolete positive regulation of corticotropin-releasing hormone receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CRH receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CRH receptor activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900013
name: obsolete cellular response to potassium ion involved in chemotaxis to cAMP
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624]
comment: This term was made obsolete because it was added by mistake.
synonym: "cellular response to K+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium ion involved in chemotaxis to cAMP" EXACT []
synonym: "cellular response to potassium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900014
name: obsolete cellular response to calcium ion involved in chemotaxis to cAMP
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624, PMID:8937985]
synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie]
synonym: "cellular response to calcium ion involved in chemotaxis to cAMP" EXACT []
synonym: "cellular response to calcium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900015
name: regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0002534 ! cytokine production involved in inflammatory response

[Term]
id: GO:1900016
name: negative regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
relationship: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response

[Term]
id: GO:1900017
name: positive regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
relationship: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response

[Term]
id: GO:1900018
name: obsolete phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex." [GOC:rb, GOC:TermGenie, PMID:10594013, PMID:19666497]
comment: This term was obsoleted because it represents both a molecular function and a biological process.
is_obsolete: true
consider: GO:0006370
consider: GO:0140836

[Term]
id: GO:1900019
name: regulation of protein kinase C activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of PKC" RELATED [GOC:TermGenie]
synonym: "regulation of PKC activity" EXACT [GOC:TermGenie]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:1900020
name: positive regulation of protein kinase C activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of PKC" RELATED [GOC:TermGenie]
synonym: "positive regulation of PKC activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PKC" RELATED [GOC:TermGenie]
synonym: "up regulation of PKC activity" EXACT [GOC:TermGenie]
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:1900019 ! regulation of protein kinase C activity

[Term]
id: GO:1900022
name: obsolete regulation of D-erythro-sphingosine kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of sphingosine kinase activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0019207

[Term]
id: GO:1900023
name: obsolete positive regulation of D-erythro-sphingosine kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of sphingosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of D-erythro-sphingosine kinase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of sphingosine kinase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900024
name: regulation of substrate adhesion-dependent cell spreading
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
relationship: regulates GO:0034446 ! substrate adhesion-dependent cell spreading

[Term]
id: GO:1900025
name: negative regulation of substrate adhesion-dependent cell spreading
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
synonym: "down regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "negative regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading
relationship: negatively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading

[Term]
id: GO:1900026
name: positive regulation of substrate adhesion-dependent cell spreading
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]
synonym: "positive regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "positive regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
synonym: "up regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie]
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading
relationship: positively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading

[Term]
id: GO:1900027
name: regulation of ruffle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "regulation of membrane ruffling" EXACT [GOC:TermGenie]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: regulates GO:0097178 ! ruffle assembly

[Term]
id: GO:1900028
name: negative regulation of ruffle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane ruffling" EXACT [GOC:TermGenie]
synonym: "down regulation of ruffle assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of membrane ruffling" EXACT [GOC:TermGenie]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1900027 ! regulation of ruffle assembly
relationship: negatively_regulates GO:0097178 ! ruffle assembly

[Term]
id: GO:1900029
name: positive regulation of ruffle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
synonym: "positive regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of membrane ruffling" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane ruffling" EXACT [GOC:TermGenie]
synonym: "up regulation of ruffle assembly" RELATED [GOC:TermGenie]
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1900027 ! regulation of ruffle assembly
relationship: positively_regulates GO:0097178 ! ruffle assembly

[Term]
id: GO:1900030
name: regulation of pectin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pectin biosynthetic process." [GOC:TermGenie]
synonym: "regulation of pectin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pectin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pectin formation" EXACT [GOC:TermGenie]
synonym: "regulation of pectin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0045489 ! pectin biosynthetic process

[Term]
id: GO:1900031
name: obsolete regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036]
synonym: "global transcription regulation from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signalling" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0006357
consider: GO:0019722

[Term]
id: GO:1900032
name: regulation of trichome patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trichome patterning." [GOC:TermGenie]
synonym: "regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "regulation of trichome spacing" EXACT [GOC:TermGenie]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048629 ! trichome patterning

[Term]
id: GO:1900033
name: negative regulation of trichome patterning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trichome patterning." [GOC:TermGenie]
synonym: "down regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "down regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "down regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "down regulation of trichome patterning" RELATED [GOC:TermGenie]
synonym: "down regulation of trichome spacing" EXACT [GOC:TermGenie]
synonym: "down-regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "down-regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "down-regulation of trichome patterning" RELATED [GOC:TermGenie]
synonym: "down-regulation of trichome spacing" EXACT [GOC:TermGenie]
synonym: "downregulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "downregulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "downregulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "downregulation of trichome patterning" RELATED [GOC:TermGenie]
synonym: "downregulation of trichome spacing" EXACT [GOC:TermGenie]
synonym: "inhibition of trichome distribution" BROAD [GOC:TermGenie]
synonym: "inhibition of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "inhibition of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "inhibition of trichome patterning" RELATED [GOC:TermGenie]
synonym: "inhibition of trichome spacing" EXACT [GOC:TermGenie]
synonym: "negative regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "negative regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "negative regulation of trichome spacing" EXACT [GOC:TermGenie]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900032 ! regulation of trichome patterning
relationship: negatively_regulates GO:0048629 ! trichome patterning

[Term]
id: GO:1900034
name: regulation of cellular response to heat
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0034605 ! cellular response to heat

[Term]
id: GO:1900035
name: negative regulation of cellular response to heat
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900034 ! regulation of cellular response to heat
relationship: negatively_regulates GO:0034605 ! cellular response to heat

[Term]
id: GO:1900036
name: positive regulation of cellular response to heat
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf]
synonym: "activation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "activation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular response to heat stress" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900034 ! regulation of cellular response to heat
relationship: positively_regulates GO:0034605 ! cellular response to heat

[Term]
id: GO:1900037
name: regulation of cellular response to hypoxia
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0071456 ! cellular response to hypoxia

[Term]
id: GO:1900038
name: negative regulation of cellular response to hypoxia
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900037 ! regulation of cellular response to hypoxia
relationship: negatively_regulates GO:0071456 ! cellular response to hypoxia

[Term]
id: GO:1900039
name: positive regulation of cellular response to hypoxia
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
synonym: "activation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "activation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "activation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900037 ! regulation of cellular response to hypoxia
relationship: positively_regulates GO:0071456 ! cellular response to hypoxia

[Term]
id: GO:1900043
name: obsolete leptin-mediated signaling pathway involved in negative regulation of appetite
namespace: biological_process
def: "OBSOLETE. Any leptin-mediated signaling pathway that is involved in negative regulation of appetite." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "adipocytokine signaling pathway of appetite suppression" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway involved in negative regulation of appetite" EXACT []
synonym: "leptin-mediated signaling pathway of appetite suppression" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of appetite suppression" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of down regulation of appetite" EXACT [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of down-regulation of appetite" EXACT [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of downregulation of appetite" EXACT [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of inhibition of appetite" NARROW [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of negative regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of negative regulation of hunger" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900044
name: regulation of protein K63-linked ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie]
synonym: "regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1902914 ! regulation of protein polyubiquitination
relationship: regulates GO:0070534 ! protein K63-linked ubiquitination

[Term]
id: GO:1900045
name: negative regulation of protein K63-linked ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie]
synonym: "down regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "downregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "inhibition of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination
is_a: GO:1902915 ! negative regulation of protein polyubiquitination
relationship: negatively_regulates GO:0070534 ! protein K63-linked ubiquitination

[Term]
id: GO:1900046
name: regulation of hemostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemostasis." [GOC:TermGenie]
is_a: GO:0050789 ! regulation of biological process
is_a: GO:0050878 ! regulation of body fluid levels
relationship: regulates GO:0007599 ! hemostasis

[Term]
id: GO:1900047
name: negative regulation of hemostasis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." [GOC:TermGenie]
synonym: "down regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of hemostasis" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1900046 ! regulation of hemostasis
relationship: negatively_regulates GO:0007599 ! hemostasis

[Term]
id: GO:1900048
name: positive regulation of hemostasis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemostasis." [GOC:TermGenie]
synonym: "activation of hemostasis" NARROW [GOC:TermGenie]
synonym: "up regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemostasis" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1900046 ! regulation of hemostasis
relationship: positively_regulates GO:0007599 ! hemostasis

[Term]
id: GO:1900049
name: obsolete regulation of histone exchange
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092]
comment: This term was obsoleted because it represents a molecular function (histone chaperone activity).
synonym: "regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "regulation of histone displacement" EXACT [GOC:TermGenie]
synonym: "regulation of histone replacement" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0006338
consider: GO:0140713

[Term]
id: GO:1900050
name: obsolete negative regulation of histone exchange
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092]
comment: This term was obsoleted because it represents a molecular function, histone chaperone activity.
synonym: "down regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "down regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "down regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "down-regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "downregulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "downregulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "inhibition of histone chaperone" RELATED [GOC:TermGenie]
synonym: "inhibition of histone exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of histone replacement" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "negative regulation of histone replacement" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0006338
consider: GO:0140713

[Term]
id: GO:1900051
name: obsolete positive regulation of histone exchange
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "activation of histone exchange" RELATED [GOC:TermGenie]
synonym: "activation of histone replacement" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "positive regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "up regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "up regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "up-regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "upregulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "upregulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of histone replacement" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0006338
consider: GO:0140713

[Term]
id: GO:1900052
name: regulation of retinoic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0002138 ! retinoic acid biosynthetic process

[Term]
id: GO:1900053
name: negative regulation of retinoic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process
relationship: negatively_regulates GO:0002138 ! retinoic acid biosynthetic process

[Term]
id: GO:1900054
name: positive regulation of retinoic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "activation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process
relationship: positively_regulates GO:0002138 ! retinoic acid biosynthetic process

[Term]
id: GO:1900055
name: regulation of leaf senescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf senescence." [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0010150 ! leaf senescence

[Term]
id: GO:1900056
name: negative regulation of leaf senescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence." [GOC:TermGenie]
synonym: "down regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "down-regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "downregulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "inhibition of leaf senescence" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1900055 ! regulation of leaf senescence
relationship: negatively_regulates GO:0010150 ! leaf senescence

[Term]
id: GO:1900057
name: positive regulation of leaf senescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leaf senescence." [GOC:TermGenie]
synonym: "activation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "up regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "up-regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "upregulation of leaf senescence" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1900055 ! regulation of leaf senescence
relationship: positively_regulates GO:0010150 ! leaf senescence

[Term]
id: GO:1900058
name: regulation of sulfate assimilation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681]
synonym: "regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0000103 ! sulfate assimilation

[Term]
id: GO:1900059
name: positive regulation of sulfate assimilation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681]
synonym: "activation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "activation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900058 ! regulation of sulfate assimilation
relationship: positively_regulates GO:0000103 ! sulfate assimilation

[Term]
id: GO:1900060
name: negative regulation of ceramide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:TermGenie, PMID:15302821]
synonym: "down regulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of ceramide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process
is_a: GO:2000303 ! regulation of ceramide biosynthetic process
relationship: negatively_regulates GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:1900061
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036]
comment: This term was made obsolete because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signaling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0019722
consider: GO:0045944

[Term]
id: GO:1900062
name: obsolete regulation of replicative cell aging
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of replicative cell aging." [GOC:TermGenie, PMID:17914901]
comment: This term was obsoleted because it represents an assay, not a true biological process.
synonym: "regulation of replicative cell ageing" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900063
name: regulation of peroxisome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953]
synonym: "regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007031 ! peroxisome organization

[Term]
id: GO:1900064
name: positive regulation of peroxisome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953]
synonym: "activation of peroxisome organisation" NARROW [GOC:TermGenie]
synonym: "activation of peroxisome organization" NARROW [GOC:TermGenie]
synonym: "activation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of peroxisome organization" RELATED [GOC:TermGenie]
synonym: "up regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peroxisome organization" RELATED [GOC:TermGenie]
synonym: "up-regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of peroxisome organization" RELATED [GOC:TermGenie]
synonym: "upregulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1900063 ! regulation of peroxisome organization
relationship: positively_regulates GO:0007031 ! peroxisome organization

[Term]
id: GO:1900065
name: regulation of ethanol catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841]
synonym: "regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ethanol degradation" EXACT [GOC:TermGenie]
is_a: GO:1900419 ! regulation of alcohol catabolic process
relationship: regulates GO:0006068 ! ethanol catabolic process

[Term]
id: GO:1900066
name: positive regulation of ethanol catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841]
synonym: "activation of ethanol breakdown" NARROW [GOC:TermGenie]
synonym: "activation of ethanol catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ethanol catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ethanol degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ethanol degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ethanol catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ethanol degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ethanol catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ethanol degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol degradation" EXACT [GOC:TermGenie]
is_a: GO:1900065 ! regulation of ethanol catabolic process
is_a: GO:1900421 ! positive regulation of alcohol catabolic process
relationship: positively_regulates GO:0006068 ! ethanol catabolic process

[Term]
id: GO:1900067
name: regulation of cellular response to alkaline pH
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]
synonym: "regulation of cellular response to alkalinity" BROAD []
synonym: "regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0071469 ! cellular response to alkaline pH

[Term]
id: GO:1900068
name: negative regulation of cellular response to alkaline pH
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to alkaline pH" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to alkalinity" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to basic pH" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to alkalinity" BROAD []
synonym: "negative regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900067 ! regulation of cellular response to alkaline pH
relationship: negatively_regulates GO:0071469 ! cellular response to alkaline pH

[Term]
id: GO:1900069
name: regulation of cellular hyperosmotic salinity response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455]
synonym: "regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
is_a: GO:0106049 ! regulation of cellular response to osmotic stress
is_a: GO:1901000 ! regulation of response to salt stress
relationship: regulates GO:0071475 ! cellular hyperosmotic salinity response

[Term]
id: GO:1900070
name: negative regulation of cellular hyperosmotic salinity response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular hyperosmotic salinity response" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to hyperosmotic salt stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900069 ! regulation of cellular hyperosmotic salinity response
is_a: GO:1901001 ! negative regulation of response to salt stress
relationship: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response

[Term]
id: GO:1900071
name: regulation of sulfite transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sulfite transmembrane transport." [GOC:TermGenie, PMID:10234785, PMID:10870099]
synonym: "regulation of sulfite transport" EXACT []
synonym: "regulation of sulphite transport" EXACT [GOC:TermGenie]
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
relationship: regulates GO:0000316 ! sulfite transmembrane transport

[Term]
id: GO:1900072
name: positive regulation of sulfite transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfite transmembrane transport." [GOC:TermGenie, PMID:10234785, PMID:10870099]
subset: gocheck_do_not_annotate
synonym: "activation of sulfite transport" NARROW [GOC:TermGenie]
synonym: "activation of sulphite transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulfite transport" EXACT []
synonym: "positive regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "up regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "up-regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "upregulation of sulphite transport" EXACT [GOC:TermGenie]
is_a: GO:1900071 ! regulation of sulfite transmembrane transport
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
relationship: positively_regulates GO:0000316 ! sulfite transmembrane transport

[Term]
id: GO:1900073
name: regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
relationship: regulates GO:0007274 ! neuromuscular synaptic transmission

[Term]
id: GO:1900074
name: negative regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "downregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "inhibition of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission
relationship: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission

[Term]
id: GO:1900075
name: positive regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
synonym: "activation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "up regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "upregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission
relationship: positively_regulates GO:0007274 ! neuromuscular synaptic transmission

[Term]
id: GO:1900076
name: regulation of cellular response to insulin stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0032869 ! cellular response to insulin stimulus

[Term]
id: GO:1900077
name: negative regulation of cellular response to insulin stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900076 ! regulation of cellular response to insulin stimulus
relationship: negatively_regulates GO:0032869 ! cellular response to insulin stimulus

[Term]
id: GO:1900078
name: positive regulation of cellular response to insulin stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf]
synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900076 ! regulation of cellular response to insulin stimulus
relationship: positively_regulates GO:0032869 ! cellular response to insulin stimulus

[Term]
id: GO:1900079
name: regulation of arginine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie]
synonym: "regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "regulation of arginine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
is_a: GO:0000821 ! regulation of arginine metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0006526 ! L-arginine biosynthetic process

[Term]
id: GO:1900080
name: positive regulation of arginine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie]
synonym: "activation of arginine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of arginine formation" NARROW [GOC:TermGenie]
synonym: "activation of arginine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900079 ! regulation of arginine biosynthetic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
relationship: positively_regulates GO:0006526 ! L-arginine biosynthetic process

[Term]
id: GO:1900081
name: regulation of arginine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie]
synonym: "regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of arginine degradation" EXACT [GOC:TermGenie]
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
is_a: GO:0000821 ! regulation of arginine metabolic process
is_a: GO:0033241 ! regulation of amine catabolic process
relationship: regulates GO:0006527 ! arginine catabolic process

[Term]
id: GO:1900082
name: negative regulation of arginine catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie]
synonym: "down regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of arginine catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of arginine degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of arginine breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of arginine catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of arginine catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of arginine degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine degradation" EXACT [GOC:TermGenie]
is_a: GO:0033242 ! negative regulation of amine catabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900081 ! regulation of arginine catabolic process
relationship: negatively_regulates GO:0006527 ! arginine catabolic process

[Term]
id: GO:1900083
name: obsolete regulation of Sertoli cell proliferation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Sertoli cell proliferation." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of Sertoli cell proliferation" EXACT []
is_obsolete: true

[Term]
id: GO:1900084
name: regulation of peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0031952 ! regulation of protein autophosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation

[Term]
id: GO:1900085
name: negative regulation of peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "down regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "down-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "downregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0031953 ! negative regulation of protein autophosphorylation
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation
relationship: negatively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation

[Term]
id: GO:1900086
name: positive regulation of peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "up regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "up-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "upregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0031954 ! positive regulation of protein autophosphorylation
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation
relationship: positively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation

[Term]
id: GO:1900087
name: positive regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
synonym: "activation of G1/S transition of mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "up regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
is_a: GO:1902808 ! positive regulation of cell cycle G1/S phase transition
is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle
relationship: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:1900088
name: regulation of inositol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0006021 ! inositol biosynthetic process

[Term]
id: GO:1900089
name: negative regulation of inositol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "down regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of inositol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1900088 ! regulation of inositol biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0006021 ! inositol biosynthetic process

[Term]
id: GO:1900090
name: positive regulation of inositol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "activation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of inositol formation" EXACT [GOC:TermGenie]
synonym: "activation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1900088 ! regulation of inositol biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0006021 ! inositol biosynthetic process

[Term]
id: GO:1900091
name: regulation of raffinose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "regulation of raffinose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:0080091 ! regulation of raffinose metabolic process
relationship: regulates GO:0033529 ! raffinose biosynthetic process

[Term]
id: GO:1900092
name: negative regulation of raffinose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "down regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of raffinose formation" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1900091 ! regulation of raffinose biosynthetic process
relationship: negatively_regulates GO:0033529 ! raffinose biosynthetic process

[Term]
id: GO:1900093
name: positive regulation of raffinose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "activation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "activation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of raffinose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "activation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1900091 ! regulation of raffinose biosynthetic process
relationship: positively_regulates GO:0033529 ! raffinose biosynthetic process

[Term]
id: GO:1900094
name: obsolete regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in determination of left/right symmetry." [GOC:BHF, GOC:TermGenie]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "global transcription regulation from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right symmetry" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900095
name: obsolete regulation of dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:mr, GOC:TermGenie, PMID:20622855, Wikipedia:XY_sex-determination_system]
comment: This term was obsoleted because the parent class dosage compensation is already a regulatory process.
synonym: "regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0009048

[Term]
id: GO:1900096
name: obsolete negative regulation of dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie]
comment: This term was obsoleted because the parent class dosage compensation is already a regulatory process.
synonym: "down regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "down regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "down regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "down regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "down-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "downregulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "downregulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "downregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "downregulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "inhibition of Barr body formation" RELATED [GOC:TermGenie]
synonym: "inhibition of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "inhibition of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie]
synonym: "inhibition of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "negative regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0009048

[Term]
id: GO:1900097
name: obsolete positive regulation of dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie]
comment: This term was obsoleted because the parent class dosage compensation is already a regulatory process.
synonym: "activation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "activation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "activation of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie]
synonym: "activation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "positive regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "up regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "up regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "up regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "up regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "up-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "upregulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "upregulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "upregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "upregulation of X chromosome inactivation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0009048

[Term]
id: GO:1900098
name: regulation of plasma cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie]
synonym: "regulation of plasma cell development" RELATED [GOC:TermGenie]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002317 ! plasma cell differentiation

[Term]
id: GO:1900099
name: negative regulation of plasma cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie]
synonym: "down regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "down regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "down-regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "downregulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of plasma cell development" RELATED [GOC:TermGenie]
synonym: "inhibition of plasma cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of plasma cell development" RELATED [GOC:TermGenie]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0045578 ! negative regulation of B cell differentiation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:1900098 ! regulation of plasma cell differentiation
relationship: negatively_regulates GO:0002317 ! plasma cell differentiation

[Term]
id: GO:1900100
name: positive regulation of plasma cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie]
synonym: "activation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "activation of plasma cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "up regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "up regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "up-regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "upregulation of plasma cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0045579 ! positive regulation of B cell differentiation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:1900098 ! regulation of plasma cell differentiation
relationship: positively_regulates GO:0002317 ! plasma cell differentiation

[Term]
id: GO:1900101
name: regulation of endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie]
synonym: "regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress
relationship: regulates GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:1900102
name: negative regulation of endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "down regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of erUPR" EXACT [GOC:TermGenie]
synonym: "downregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "inhibition of erUPR" EXACT [GOC:TermGenie]
synonym: "inhibition of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "negative regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress
relationship: negatively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:1900103
name: positive regulation of endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "activation of erUPR" EXACT [GOC:TermGenie]
synonym: "activation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "positive regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "up regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of erUPR" EXACT [GOC:TermGenie]
synonym: "upregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress
relationship: positively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:1900104
name: regulation of hyaluranon cable assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of HA cable assembly" EXACT [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0036118 ! hyaluranon cable assembly

[Term]
id: GO:1900105
name: negative regulation of hyaluranon cable assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluranon cable assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of HA cable assembly" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1900104 ! regulation of hyaluranon cable assembly
relationship: negatively_regulates GO:0036118 ! hyaluranon cable assembly

[Term]
id: GO:1900106
name: positive regulation of hyaluranon cable assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf]
synonym: "activation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "activation of hyaluranon cable assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1900104 ! regulation of hyaluranon cable assembly
relationship: positively_regulates GO:0036118 ! hyaluranon cable assembly

[Term]
id: GO:1900107
name: regulation of nodal signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk]
synonym: "regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "regulation of nodal signalling pathway" EXACT [GOC:mah]
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
relationship: regulates GO:0038092 ! nodal signaling pathway

[Term]
id: GO:1900108
name: negative regulation of nodal signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk]
synonym: "down regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of nodal signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of nodal signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of nodal signalling pathway" EXACT [GOC:mah]
is_a: GO:0032926 ! negative regulation of activin receptor signaling pathway
is_a: GO:1900107 ! regulation of nodal signaling pathway
relationship: negatively_regulates GO:0038092 ! nodal signaling pathway

[Term]
id: GO:1900109
name: obsolete regulation of histone H3-K9 dimethylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900110
name: obsolete negative regulation of histone H3-K9 dimethylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone H3-K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900111
name: obsolete positive regulation of histone H3-K9 dimethylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "activation of histone H3-K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "activation of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900112
name: obsolete regulation of histone H3-K9 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1900113
name: obsolete negative regulation of histone H3-K9 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K9 trimethylation" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900114
name: obsolete positive regulation of histone H3-K9 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3-K9 trimethylation" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900115
name: extracellular regulation of signal transduction
namespace: biological_process
def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction

[Term]
id: GO:1900116
name: extracellular negative regulation of signal transduction
namespace: biological_process
def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf]
synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie]
synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900115 ! extracellular regulation of signal transduction

[Term]
id: GO:1900117
name: regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0097194 ! execution phase of apoptosis

[Term]
id: GO:1900118
name: negative regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
relationship: negatively_regulates GO:0097194 ! execution phase of apoptosis

[Term]
id: GO:1900119
name: positive regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
relationship: positively_regulates GO:0097194 ! execution phase of apoptosis

[Term]
id: GO:1900120
name: regulation of receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:1900121
name: negative regulation of receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:1900122
name: positive regulation of receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "activation of receptor binding" NARROW [GOC:TermGenie]
synonym: "up regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor binding" EXACT [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:1900123
name: regulation of nodal receptor complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104]
synonym: "regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0038099 ! nodal receptor complex assembly

[Term]
id: GO:1900124
name: negative regulation of nodal receptor complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104]
synonym: "down regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal receptor complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ActRIIB.ALK4.EGF-CFC complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal receptor complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal receptor complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1900123 ! regulation of nodal receptor complex assembly
relationship: negatively_regulates GO:0038099 ! nodal receptor complex assembly

[Term]
id: GO:1900125
name: regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0030213 ! hyaluronan biosynthetic process

[Term]
id: GO:1900126
name: negative regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
relationship: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process

[Term]
id: GO:1900127
name: positive regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
relationship: positively_regulates GO:0030213 ! hyaluronan biosynthetic process

[Term]
id: GO:1900128
name: regulation of G-protein activated inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity

[Term]
id: GO:1900129
name: positive regulation of G-protein activated inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of G protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein-activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein-enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1900128 ! regulation of G-protein activated inward rectifier potassium channel activity
is_a: GO:1901980 ! positive regulation of inward rectifier potassium channel activity

[Term]
id: GO:1900130
name: regulation of lipid binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:1900131
name: negative regulation of lipid binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1900130 ! regulation of lipid binding

[Term]
id: GO:1900132
name: positive regulation of lipid binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "activation of lipid binding" NARROW [GOC:TermGenie]
synonym: "up regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1900130 ! regulation of lipid binding

[Term]
id: GO:1900133
name: regulation of renin secretion into blood stream
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie]
synonym: "regulation of renin release into blood stream" EXACT [GOC:TermGenie]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:0002001 ! renin secretion into blood stream

[Term]
id: GO:1900134
name: negative regulation of renin secretion into blood stream
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie]
synonym: "down regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "down regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "down-regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "down-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "downregulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "downregulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "inhibition of renin release into blood stream" NARROW [GOC:TermGenie]
synonym: "inhibition of renin secretion into blood stream" NARROW [GOC:TermGenie]
synonym: "negative regulation of renin release into blood stream" EXACT [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:1900133 ! regulation of renin secretion into blood stream
relationship: negatively_regulates GO:0002001 ! renin secretion into blood stream

[Term]
id: GO:1900135
name: positive regulation of renin secretion into blood stream
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie]
synonym: "activation of renin release into blood stream" NARROW [GOC:TermGenie]
synonym: "activation of renin secretion into blood stream" NARROW [GOC:TermGenie]
synonym: "positive regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "up regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "up regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "up-regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "up-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "upregulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "upregulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:1900133 ! regulation of renin secretion into blood stream
relationship: positively_regulates GO:0002001 ! renin secretion into blood stream

[Term]
id: GO:1900136
name: regulation of chemokine activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
is_a: GO:0060300 ! regulation of cytokine activity

[Term]
id: GO:1900137
name: negative regulation of chemokine activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of chemokine activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemokine activity" EXACT [GOC:TermGenie]
synonym: "downregulation of chemokine activity" EXACT [GOC:TermGenie]
synonym: "inhibition of chemokine activity" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0060302 ! negative regulation of cytokine activity
is_a: GO:1900136 ! regulation of chemokine activity

[Term]
id: GO:1900138
name: negative regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "down regulation of phospholipase A2 activity" EXACT [GOC:TermGenie]
synonym: "down regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "down-regulation of phospholipase A2 activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "downregulation of phospholipase A2 activity" EXACT [GOC:TermGenie]
synonym: "downregulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lecithinase A activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of phosphatidolipase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylcholine 2-acylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipase A" RELATED [GOC:TermGenie]
synonym: "inhibition of phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "negative regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
is_a: GO:0010519 ! negative regulation of phospholipase activity
is_a: GO:0032429 ! regulation of phospholipase A2 activity

[Term]
id: GO:1900139
name: negative regulation of arachidonate secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion." [GOC:TermGenie]
synonym: "down regulation of arachidonic acid secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of arachidonic acid secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of arachidonic acid secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of arachidonic acid secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of arachidonic acid secretion" EXACT []
is_a: GO:0032304 ! negative regulation of icosanoid secretion
is_a: GO:0090237 ! regulation of arachidonate secretion
relationship: negatively_regulates GO:0050482 ! arachidonate secretion

[Term]
id: GO:1900140
name: regulation of seedling development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seedling development." [GOC:TermGenie]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0090351 ! seedling development

[Term]
id: GO:1900141
name: regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0034350 ! regulation of glial cell apoptotic process
relationship: regulates GO:0097252 ! oligodendrocyte apoptotic process

[Term]
id: GO:1900142
name: negative regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0034351 ! negative regulation of glial cell apoptotic process
is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process
relationship: negatively_regulates GO:0097252 ! oligodendrocyte apoptotic process

[Term]
id: GO:1900143
name: positive regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034352 ! positive regulation of glial cell apoptotic process
is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process
relationship: positively_regulates GO:0097252 ! oligodendrocyte apoptotic process

[Term]
id: GO:1900144
name: positive regulation of BMP secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of BMP secretion." [GOC:sart, GOC:TermGenie]
synonym: "activation of BMP protein secretion" NARROW [GOC:TermGenie]
synonym: "activation of BMP secretion" NARROW [GOC:TermGenie]
synonym: "activation of bone morphogenetic protein secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:2001284 ! regulation of BMP secretion
relationship: positively_regulates GO:0038055 ! BMP secretion

[Term]
id: GO:1900145
name: obsolete regulation of nodal signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007368
consider: GO:1900107

[Term]
id: GO:1900146
name: obsolete negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "inhibition of nodal signaling pathway involved in determination of left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "negative regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0007368
consider: GO:1900108

[Term]
id: GO:1900147
name: regulation of Schwann cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
is_a: GO:1903975 ! regulation of glial cell migration
relationship: regulates GO:0036135 ! Schwann cell migration

[Term]
id: GO:1900148
name: negative regulation of Schwann cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
synonym: "down regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell migration" NARROW [GOC:TermGenie]
is_a: GO:1900147 ! regulation of Schwann cell migration
is_a: GO:1903976 ! negative regulation of glial cell migration
relationship: negatively_regulates GO:0036135 ! Schwann cell migration

[Term]
id: GO:1900149
name: positive regulation of Schwann cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
synonym: "activation of Schwann cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell migration" EXACT [GOC:TermGenie]
is_a: GO:1900147 ! regulation of Schwann cell migration
is_a: GO:1903977 ! positive regulation of glial cell migration
relationship: positively_regulates GO:0036135 ! Schwann cell migration

[Term]
id: GO:1900150
name: regulation of defense response to fungus
namespace: biological_process
alt_id: GO:2000072
def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006]
synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to fungi, incompatible interaction" NARROW [GOC:obol]
synonym: "regulation of defense response to fungus, incompatible interaction" NARROW []
synonym: "regulation of resistance response to pathogenic fungi" NARROW [GOC:obol]
synonym: "regulation of resistance response to pathogenic fungus" NARROW [GOC:obol]
synonym: "regulation of response to pathogenic fungus (incompatible interaction)" NARROW [GOC:obol]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0050832 ! defense response to fungus

[Term]
id: GO:1900151
name: regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]
synonym: "regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
is_a: GO:0043488 ! regulation of mRNA stability
relationship: regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:1900152
name: negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]
synonym: "down regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "inhibition of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "negative regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
is_a: GO:1902373 ! negative regulation of mRNA catabolic process
relationship: negatively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:1900153
name: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]
synonym: "activation of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie]
synonym: "activation of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "activation of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "activation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "positive regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
relationship: positively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:1900154
name: regulation of bone trabecula formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0060346 ! bone trabecula formation

[Term]
id: GO:1900155
name: negative regulation of bone trabecula formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "down regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "downregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "downregulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "inhibition of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of bone trabecula formation" NARROW [GOC:TermGenie]
synonym: "inhibition of bone trabeculation" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of skeletal trabecula formation" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal trabeculation" NARROW [GOC:TermGenie]
synonym: "negative regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "negative regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1900154 ! regulation of bone trabecula formation
relationship: negatively_regulates GO:0060346 ! bone trabecula formation

[Term]
id: GO:1900156
name: positive regulation of bone trabecula formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of bone trabecula formation" NARROW [GOC:TermGenie]
synonym: "activation of bone trabeculation" NARROW [GOC:TermGenie]
synonym: "activation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of skeletal trabecula formation" NARROW [GOC:TermGenie]
synonym: "activation of skeletal trabeculation" NARROW [GOC:TermGenie]
synonym: "positive regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "positive regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "up regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "up regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "upregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "upregulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal trabeculation" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1900154 ! regulation of bone trabecula formation
relationship: positively_regulates GO:0060346 ! bone trabecula formation

[Term]
id: GO:1900157
name: regulation of bone mineralization involved in bone maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030500 ! regulation of bone mineralization
relationship: regulates GO:0035630 ! bone mineralization involved in bone maturation

[Term]
id: GO:1900158
name: negative regulation of bone mineralization involved in bone maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie]
is_a: GO:0030502 ! negative regulation of bone mineralization
is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation
relationship: negatively_regulates GO:0035630 ! bone mineralization involved in bone maturation

[Term]
id: GO:1900159
name: positive regulation of bone mineralization involved in bone maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
is_a: GO:0030501 ! positive regulation of bone mineralization
is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation
relationship: positively_regulates GO:0035630 ! bone mineralization involved in bone maturation

[Term]
id: GO:1900160
name: plastid chromosome packaging
namespace: biological_process
def: "A process in which plastidial DNA and associated proteins organize into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370]
synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie]
synonym: "DNA organization in plastid" EXACT [GOC:TermGenie]
synonym: "plastid DNA packaging" EXACT []
synonym: "plastidial DNA packaging" EXACT [GOC:emb]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:1900161
name: regulation of phospholipid scramblase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
is_a: GO:0061091 ! regulation of phospholipid translocation
is_a: GO:0110112 ! regulation of lipid transporter activity
is_a: GO:1903729 ! regulation of plasma membrane organization

[Term]
id: GO:1900162
name: obsolete negative regulation of phospholipid scramblase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipid scramblase activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900163
name: positive regulation of phospholipid scramblase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of phospholipid scramblase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
is_a: GO:0110113 ! positive regulation of lipid transporter activity
is_a: GO:1900161 ! regulation of phospholipid scramblase activity

[Term]
id: GO:1900164
name: obsolete nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by a nodal protein binding to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves." [GOC:BHF, GOC:TermGenie, GOC:vk]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003140
consider: GO:0038092

[Term]
id: GO:1900166
name: regulation of glial cell-derived neurotrophic factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor production." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of GDNF secretion" NARROW [GOC:TermGenie]
synonym: "regulation of glial cell line-derived neurotrophic factor secretion" RELATED []
synonym: "regulation of glial cell-derived neurotrophic factor secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0044467 ! glial cell-derived neurotrophic factor production

[Term]
id: GO:1900167
name: negative regulation of glial cell-derived neurotrophic factor production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor production." [GOC:TermGenie, GOC:yaf]
synonym: "inhibition of GDNF secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of glial cell line-derived neurotrophic factor secretion" RELATED []
synonym: "negative regulation of glial cell-derived neurotrophic factor secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor production
relationship: negatively_regulates GO:0044467 ! glial cell-derived neurotrophic factor production

[Term]
id: GO:1900168
name: positive regulation of glial cell-derived neurotrophic factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor production." [GOC:TermGenie, GOC:yaf]
synonym: "activation of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of GDNF production" EXACT [GOC:TermGenie]
synonym: "positive regulation of glial cell line-derived neurotrophic factor secretion" RELATED []
synonym: "positive regulation of glial cell-derived neurotrophic factor secretion" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor production
relationship: positively_regulates GO:0044467 ! glial cell-derived neurotrophic factor production

[Term]
id: GO:1900169
name: regulation of glucocorticoid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie]
synonym: "regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0043402 ! glucocorticoid mediated signaling pathway

[Term]
id: GO:1900170
name: negative regulation of glucocorticoid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie]
synonym: "down regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "downregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "inhibition of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of glucocorticoid mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway
relationship: negatively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway

[Term]
id: GO:1900171
name: positive regulation of glucocorticoid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie]
synonym: "activation of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of glucocorticoid mediated signalling" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway
relationship: positively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway

[Term]
id: GO:1900175
name: obsolete regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003140
consider: GO:1900107

[Term]
id: GO:1900176
name: obsolete negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk, PMID:15084459]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "inhibition of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "negative regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003140
consider: GO:1900108

[Term]
id: GO:1900177
name: regulation of aflatoxin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di]
synonym: "regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0045122 ! aflatoxin biosynthetic process

[Term]
id: GO:1900178
name: negative regulation of aflatoxin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di]
synonym: "down regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of aflatoxin anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin formation" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
relationship: negatively_regulates GO:0045122 ! aflatoxin biosynthetic process

[Term]
id: GO:1900179
name: positive regulation of aflatoxin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di]
synonym: "activation of aflatoxin anabolism" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin formation" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
relationship: positively_regulates GO:0045122 ! aflatoxin biosynthetic process

[Term]
id: GO:1900180
name: regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0034504 ! protein localization to nucleus

[Term]
id: GO:1900181
name: negative regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:0034504 ! protein localization to nucleus

[Term]
id: GO:1900182
name: positive regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:0034504 ! protein localization to nucleus

[Term]
id: GO:1900183
name: regulation of xanthone-containing compound biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
relationship: regulates GO:2001307 ! xanthone-containing compound biosynthetic process

[Term]
id: GO:1900184
name: negative regulation of xanthone-containing compound biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthones anabolism" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process
relationship: negatively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process

[Term]
id: GO:1900185
name: positive regulation of xanthone-containing compound biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "activation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "activation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process
relationship: positively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process

[Term]
id: GO:1900186
name: negative regulation of clathrin-dependent endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:TermGenie]
synonym: "down regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin-mediated endocytosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of clathrin-mediated endocytosis" EXACT []
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
is_a: GO:2000369 ! regulation of clathrin-dependent endocytosis
relationship: negatively_regulates GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:1900187
name: regulation of cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
relationship: regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation

[Term]
id: GO:1900188
name: negative regulation of cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "down regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "down regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation
relationship: negatively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation

[Term]
id: GO:1900189
name: positive regulation of cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "activation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "activation of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation
relationship: positively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation

[Term]
id: GO:1900190
name: regulation of single-species biofilm formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0044010 ! single-species biofilm formation

[Term]
id: GO:1900191
name: negative regulation of single-species biofilm formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "down regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "downregulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "inhibition of single-species biofilm formation" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900190 ! regulation of single-species biofilm formation
relationship: negatively_regulates GO:0044010 ! single-species biofilm formation

[Term]
id: GO:1900192
name: positive regulation of single-species biofilm formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "activation of single-species biofilm formation" NARROW [GOC:TermGenie]
synonym: "up regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "upregulation of single-species biofilm formation" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900190 ! regulation of single-species biofilm formation
relationship: positively_regulates GO:0044010 ! single-species biofilm formation

[Term]
id: GO:1900193
name: regulation of oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0001556 ! oocyte maturation

[Term]
id: GO:1900194
name: negative regulation of oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0001556 ! oocyte maturation

[Term]
id: GO:1900195
name: positive regulation of oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0001556 ! oocyte maturation

[Term]
id: GO:1900196
name: regulation of penicillin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "regulation of penicillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0042318 ! penicillin biosynthetic process

[Term]
id: GO:1900197
name: negative regulation of penicillin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of penicillin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033245 ! negative regulation of penicillin metabolic process
is_a: GO:1900196 ! regulation of penicillin biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
relationship: negatively_regulates GO:0042318 ! penicillin biosynthetic process

[Term]
id: GO:1900198
name: positive regulation of penicillin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of penicillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "activation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033246 ! positive regulation of penicillin metabolic process
is_a: GO:1900196 ! regulation of penicillin biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
relationship: positively_regulates GO:0042318 ! penicillin biosynthetic process

[Term]
id: GO:1900199
name: positive regulation of protein export from nucleus during meiotic anaphase II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm, during anaphase occurring as part of meiosis II." [GOC:al, GOC:TermGenie, PMID:20970342]
synonym: "positive regulation of protein export from nucleus involved in meiotic anaphase II" BROAD [GOC:pr]
is_a: GO:0046827 ! positive regulation of protein export from nucleus

[Term]
id: GO:1900200
name: mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:0097152 ! mesenchymal cell apoptotic process
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:1900201
name: obsolete regulation of spread of virus in host, cell to cell
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "regulation of spread of virus in host, cell to cell" EXACT []
synonym: "regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900202
name: obsolete negative regulation of spread of virus in host, cell to cell
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "down regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "down-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "downregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "downregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "downregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "downregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "inhibition of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "inhibition of spread of virus in host, cell to cell" NARROW [GOC:TermGenie]
synonym: "inhibition of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "inhibition of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "negative regulation of spread of virus in host, cell to cell" EXACT []
synonym: "negative regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900203
name: obsolete positive regulation of spread of virus in host, cell to cell
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "activation of spread of virus in host, cell to cell" NARROW [GOC:TermGenie]
synonym: "activation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "activation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "positive regulation of spread of virus in host, cell to cell" EXACT []
synonym: "positive regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "up regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "up-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "upregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "upregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "upregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "upregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900204
name: apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any apoptotic process that is involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0072205 ! metanephric collecting duct development

[Term]
id: GO:1900205
name: apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any apoptotic process that is involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0072234 ! metanephric nephron tubule development

[Term]
id: GO:1900206
name: regulation of pronephric nephron tubule development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pronephric nephron tubule development." [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0039020 ! pronephric nephron tubule development

[Term]
id: GO:1900207
name: negative regulation of pronephric nephron tubule development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development." [GOC:bf, GOC:TermGenie, PMID:9758706]
synonym: "down regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of pronephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1900206 ! regulation of pronephric nephron tubule development
relationship: negatively_regulates GO:0039020 ! pronephric nephron tubule development

[Term]
id: GO:1900208
name: regulation of cardiolipin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie]
synonym: "regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: regulates GO:0032048 ! cardiolipin metabolic process

[Term]
id: GO:1900209
name: negative regulation of cardiolipin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie]
synonym: "down regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of cardiolipin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
is_a: GO:1900208 ! regulation of cardiolipin metabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
relationship: negatively_regulates GO:0032048 ! cardiolipin metabolic process

[Term]
id: GO:1900210
name: positive regulation of cardiolipin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie]
synonym: "activation of cardiolipin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "activation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "activation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
is_a: GO:1900208 ! regulation of cardiolipin metabolic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
relationship: positively_regulates GO:0032048 ! cardiolipin metabolic process

[Term]
id: GO:1900211
name: regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:1904748 ! regulation of apoptotic process involved in development
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
relationship: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development

[Term]
id: GO:1900212
name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie]
synonym: "negative regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process
relationship: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development

[Term]
id: GO:1900213
name: positive regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie]
synonym: "positive regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
synonym: "up regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process
relationship: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development

[Term]
id: GO:1900214
name: regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1904748 ! regulation of apoptotic process involved in development
relationship: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development

[Term]
id: GO:1900215
name: negative regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
relationship: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development

[Term]
id: GO:1900216
name: positive regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
relationship: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development

[Term]
id: GO:1900217
name: regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1904748 ! regulation of apoptotic process involved in development
relationship: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development

[Term]
id: GO:1900218
name: negative regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
relationship: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development

[Term]
id: GO:1900219
name: positive regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
relationship: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development

[Term]
id: GO:1900220
name: semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
relationship: part_of GO:0061430 ! bone trabecula morphogenesis

[Term]
id: GO:1900221
name: regulation of amyloid-beta clearance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of beta-amyloid clearance" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0097242 ! amyloid-beta clearance

[Term]
id: GO:1900222
name: negative regulation of amyloid-beta clearance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-amyloid clearance" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-amyloid clearance" EXACT []
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900221 ! regulation of amyloid-beta clearance
relationship: negatively_regulates GO:0097242 ! amyloid-beta clearance

[Term]
id: GO:1900223
name: positive regulation of amyloid-beta clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie]
synonym: "activation of beta-amyloid clearance" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-amyloid clearance" EXACT []
synonym: "up regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1900221 ! regulation of amyloid-beta clearance
relationship: positively_regulates GO:0097242 ! amyloid-beta clearance

[Term]
id: GO:1900224
name: obsolete positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "activation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "activation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "positive regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "positive regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "positive regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
synonym: "up regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "up regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "up-regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "up-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up-regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "upregulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "upregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "upregulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0003140
consider: GO:0141092

[Term]
id: GO:1900225
name: regulation of NLRP3 inflammasome complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie]
synonym: "regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: part_of GO:0141085 ! regulation of inflammasome-mediated signaling pathway
relationship: regulates GO:0044546 ! NLRP3 inflammasome complex assembly

[Term]
id: GO:1900226
name: negative regulation of NLRP3 inflammasome complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie]
synonym: "down regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "down regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "down-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "downregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "inhibition of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly
relationship: negatively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly
relationship: part_of GO:0141086 ! negative regulation of inflammasome-mediated signaling pathway

[Term]
id: GO:1900227
name: positive regulation of NLRP3 inflammasome complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie]
synonym: "activation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "activation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "activation of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "up regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "up regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "up-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "upregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly
relationship: part_of GO:0141087 ! positive regulation of inflammasome-mediated signaling pathway
relationship: positively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly

[Term]
id: GO:1900228
name: regulation of single-species biofilm formation in or on host organism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie]
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
is_a: GO:1900190 ! regulation of single-species biofilm formation
relationship: regulates GO:0044407 ! single-species biofilm formation in or on host organism

[Term]
id: GO:1900229
name: negative regulation of single-species biofilm formation in or on host organism
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie]
synonym: "down regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "downregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "inhibition of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie]
is_a: GO:1900191 ! negative regulation of single-species biofilm formation
is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism
relationship: negatively_regulates GO:0044407 ! single-species biofilm formation in or on host organism

[Term]
id: GO:1900230
name: positive regulation of single-species biofilm formation in or on host organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie]
synonym: "activation of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie]
synonym: "up regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "upregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
is_a: GO:1900192 ! positive regulation of single-species biofilm formation
is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism
relationship: positively_regulates GO:0044407 ! single-species biofilm formation in or on host organism

[Term]
id: GO:1900231
name: regulation of single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie]
is_a: GO:1900190 ! regulation of single-species biofilm formation
relationship: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate

[Term]
id: GO:1900232
name: negative regulation of single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie]
synonym: "down regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "downregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "inhibition of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie]
is_a: GO:1900191 ! negative regulation of single-species biofilm formation
is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate
relationship: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate

[Term]
id: GO:1900233
name: positive regulation of single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie]
synonym: "activation of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie]
synonym: "up regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "upregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
is_a: GO:1900192 ! positive regulation of single-species biofilm formation
is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate
relationship: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate

[Term]
id: GO:1900234
name: regulation of Kit signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of Kit signalling pathway" EXACT [GOC:mah]
synonym: "regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0038109 ! Kit signaling pathway

[Term]
id: GO:1900235
name: negative regulation of Kit signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie]
synonym: "down regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Kit signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Kit signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1900234 ! regulation of Kit signaling pathway
relationship: negatively_regulates GO:0038109 ! Kit signaling pathway

[Term]
id: GO:1900236
name: positive regulation of Kit signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie]
synonym: "activation of Kit signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Kit signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1900234 ! regulation of Kit signaling pathway
relationship: positively_regulates GO:0038109 ! Kit signaling pathway

[Term]
id: GO:1900237
name: positive regulation of induction of conjugation with cellular fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion." [GOC:TermGenie]
synonym: "up regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie]
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion
relationship: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion

[Term]
id: GO:1900238
name: regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulation of metanephric mesenchymal cell migration, by platelet-derived growth factor receptor-beta signaling pathway." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:19019919]
synonym: "regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
synonym: "regulation of metanephric mesenchyme chemotaxis by platelet-derived growth factor receptor-beta signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration

[Term]
id: GO:1900239
name: regulation of phenotypic switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0036166 ! phenotypic switching

[Term]
id: GO:1900240
name: negative regulation of phenotypic switching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "down regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down-regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "downregulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "downregulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "inhibition of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "inhibition of phenotypic switching" NARROW [GOC:TermGenie]
synonym: "negative regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900239 ! regulation of phenotypic switching
relationship: negatively_regulates GO:0036166 ! phenotypic switching

[Term]
id: GO:1900241
name: positive regulation of phenotypic switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "activation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "activation of phenotypic switching" NARROW [GOC:TermGenie]
synonym: "positive regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up-regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "upregulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "upregulation of phenotypic switching" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900239 ! regulation of phenotypic switching
relationship: positively_regulates GO:0036166 ! phenotypic switching

[Term]
id: GO:1900242
name: regulation of synaptic vesicle endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
subset: goslim_synapse
synonym: "regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:1903421 ! regulation of synaptic vesicle recycling
relationship: regulates GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:1900243
name: negative regulation of synaptic vesicle endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle endocytosis" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis
is_a: GO:1903422 ! negative regulation of synaptic vesicle recycling
relationship: negatively_regulates GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:1900244
name: positive regulation of synaptic vesicle endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
synonym: "activation of synaptic vesicle endocytosis" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis
is_a: GO:1903423 ! positive regulation of synaptic vesicle recycling
relationship: positively_regulates GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:1900245
name: positive regulation of MDA-5 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway." [GOC:TermGenie]
synonym: "activation of IFIH1 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of MDA-5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of melanoma differentiation-associated gene 5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0039533 ! regulation of MDA-5 signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0039530 ! MDA-5 signaling pathway

[Term]
id: GO:1900246
name: positive regulation of RIG-I signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway." [GOC:TermGenie]
synonym: "activation of DDX58 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of retinoic acid inducible gene I signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of RIG-I signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of RIG-I signalling pathway" EXACT [GOC:mah]
synonym: "up regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of RIG-I signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0039535 ! regulation of RIG-I signaling pathway
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0039529 ! RIG-I signaling pathway

[Term]
id: GO:1900247
name: regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
is_a: GO:0006448 ! regulation of translational elongation
relationship: regulates GO:0002182 ! cytoplasmic translational elongation

[Term]
id: GO:1900248
name: negative regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
is_a: GO:2000766 ! negative regulation of cytoplasmic translation
relationship: negatively_regulates GO:0002182 ! cytoplasmic translational elongation

[Term]
id: GO:1900249
name: positive regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
relationship: positively_regulates GO:0002182 ! cytoplasmic translational elongation

[Term]
id: GO:1900256
name: obsolete regulation of beta1-adrenergic receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900257
name: obsolete negative regulation of beta1-adrenergic receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "down regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "downregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "inhibition of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900258
name: obsolete positive regulation of beta1-adrenergic receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "activation of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "up regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "up regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "upregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900259
name: regulation of RNA-dependent RNA polymerase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA-directed 5'-3' RNA polymerase activity" EXACT []
synonym: "regulation of transcriptase" BROAD [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1900260
name: negative regulation of RNA-dependent RNA polymerase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "down regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "down regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "down regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "down regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "down regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "down-regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "down-regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "down-regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "down-regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "down-regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "down-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "downregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "downregulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "downregulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "downregulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "downregulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "downregulation of RDRP" RELATED [GOC:TermGenie]
synonym: "downregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "inhibition of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "inhibition of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "inhibition of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "inhibition of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "inhibition of polymerase L" RELATED [GOC:TermGenie]
synonym: "inhibition of RDRP" RELATED [GOC:TermGenie]
synonym: "inhibition of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of transcriptase" BROAD [GOC:TermGenie]
synonym: "negative regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "negative regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "negative regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "negative regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "negative regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "negative regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "negative regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA-directed 5'-3' RNA polymerase activity" EXACT []
synonym: "negative regulation of RNA-directed RNA polymerase activity" BROAD []
synonym: "negative regulation of transcriptase" BROAD [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1900259 ! regulation of RNA-dependent RNA polymerase activity

[Term]
id: GO:1900261
name: obsolete positive regulation of RNA-dependent RNA polymerase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "activation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "activation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "activation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "activation of polymerase L" RELATED [GOC:TermGenie]
synonym: "activation of RDRP" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "activation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "activation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of transcriptase" BROAD [GOC:TermGenie]
synonym: "positive regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "positive regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "positive regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "positive regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "positive regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "positive regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "positive regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA-directed 5'-3' RNA polymerase activity" EXACT []
synonym: "positive regulation of RNA-directed RNA polymerase activity" BROAD []
synonym: "positive regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "up regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "up regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "up regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "up regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "up regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "up regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "up-regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "up-regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "up-regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "up-regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "up-regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "up-regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "upregulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "upregulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "upregulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "upregulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "upregulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "upregulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RDRP" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of transcriptase" BROAD [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900262
name: regulation of DNA-directed DNA polymerase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
is_a: GO:2000278 ! regulation of DNA biosynthetic process

[Term]
id: GO:1900263
name: obsolete negative regulation of DNA-directed DNA polymerase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "down regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "down regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "down regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "down regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "down-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "down-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "down-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down-regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "down-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of duplicase" BROAD [GOC:TermGenie]
synonym: "downregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "downregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of sequenase" RELATED [GOC:TermGenie]
synonym: "downregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "downregulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "downregulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "downregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of duplicase" BROAD [GOC:TermGenie]
synonym: "inhibition of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "inhibition of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sequenase" RELATED [GOC:TermGenie]
synonym: "inhibition of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "inhibition of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "inhibition of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "inhibition of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "negative regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "negative regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "negative regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "negative regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "negative regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "negative regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900264
name: positive regulation of DNA-directed DNA polymerase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "activation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "activation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of duplicase" BROAD [GOC:TermGenie]
synonym: "activation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "activation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of sequenase" RELATED [GOC:TermGenie]
synonym: "activation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "activation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "activation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "activation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "positive regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "positive regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "positive regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "positive regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "positive regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "positive regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "up regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "up regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "up regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "up regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "up-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "up-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "up-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up-regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "up-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of duplicase" BROAD [GOC:TermGenie]
synonym: "upregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "upregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of sequenase" RELATED [GOC:TermGenie]
synonym: "upregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "upregulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "upregulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "upregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process

[Term]
id: GO:1900265
name: regulation of substance P receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:1900266
name: negative regulation of substance P receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "down-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "downregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "inhibition of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of substance P receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "negative regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1900265 ! regulation of substance P receptor binding

[Term]
id: GO:1900267
name: positive regulation of substance P receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "activation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "activation of substance P receptor binding" NARROW [GOC:TermGenie]
synonym: "activation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "positive regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "up regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "up-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "upregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1900265 ! regulation of substance P receptor binding

[Term]
id: GO:1900268
name: regulation of reverse transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reverse transcription." [GOC:TermGenie]
is_a: GO:2000278 ! regulation of DNA biosynthetic process
relationship: regulates GO:0001171 ! reverse transcription

[Term]
id: GO:1900269
name: negative regulation of reverse transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse transcription." [GOC:TermGenie]
synonym: "down regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "down-regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "downregulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "inhibition of reverse transcription" NARROW [GOC:TermGenie]
is_a: GO:1900268 ! regulation of reverse transcription
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
relationship: negatively_regulates GO:0001171 ! reverse transcription

[Term]
id: GO:1900270
name: positive regulation of reverse transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reverse transcription." [GOC:TermGenie]
synonym: "activation of reverse transcription" NARROW [GOC:TermGenie]
synonym: "up regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of reverse transcription" EXACT [GOC:TermGenie]
is_a: GO:1900268 ! regulation of reverse transcription
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
relationship: positively_regulates GO:0001171 ! reverse transcription

[Term]
id: GO:1900271
name: regulation of long-term synaptic potentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "regulation of LTP" RELATED [GOC:TermGenie]
is_a: GO:0048167 ! regulation of synaptic plasticity
relationship: regulates GO:0060291 ! long-term synaptic potentiation

[Term]
id: GO:1900272
name: negative regulation of long-term synaptic potentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "down regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of LTP" RELATED [GOC:TermGenie]
synonym: "down-regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "down-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of LTP" RELATED [GOC:TermGenie]
synonym: "downregulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "downregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of LTP" RELATED [GOC:TermGenie]
synonym: "inhibition of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "inhibition of long-term synaptic potentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of LTP" RELATED [GOC:TermGenie]
synonym: "negative regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "negative regulation of LTP" RELATED [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1900271 ! regulation of long-term synaptic potentiation
relationship: negatively_regulates GO:0060291 ! long-term synaptic potentiation

[Term]
id: GO:1900273
name: positive regulation of long-term synaptic potentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "activation of long-term synaptic potentiation" NARROW [GOC:TermGenie]
synonym: "activation of LTP" RELATED [GOC:TermGenie]
synonym: "positive regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "positive regulation of LTP" RELATED [GOC:TermGenie]
synonym: "up regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "up regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of LTP" RELATED [GOC:TermGenie]
synonym: "up-regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "up-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of LTP" RELATED [GOC:TermGenie]
synonym: "upregulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "upregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of LTP" RELATED [GOC:TermGenie]
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900271 ! regulation of long-term synaptic potentiation
relationship: positively_regulates GO:0060291 ! long-term synaptic potentiation

[Term]
id: GO:1900274
name: obsolete regulation of phospholipase C activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "regulation of phosphatidase C" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900275
name: obsolete negative regulation of phospholipase C activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "down regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "down regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "down regulation of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "down regulation of phospholipase C activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "down-regulation of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "down-regulation of phospholipase C activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "downregulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "downregulation of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "downregulation of phospholipase C activity" EXACT [GOC:TermGenie]
synonym: "inhibition of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "inhibition of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "inhibition of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "inhibition of phospholipase C activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "negative regulation of phosphatidase C" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900276
name: regulation of proteinase activated receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
is_a: GO:0010469 ! regulation of signaling receptor activity

[Term]
id: GO:1900277
name: obsolete negative regulation of proteinase activated receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of proteinase activated receptor activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900278
name: obsolete positive regulation of proteinase activated receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of proteinase activated receptor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900279
name: regulation of CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie]
synonym: "regulation of CD4-positive, alpha beta T cell costimulation" EXACT []
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000523 ! regulation of T cell costimulation
relationship: regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation

[Term]
id: GO:1900280
name: negative regulation of CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie]
synonym: "down regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "downregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "inhibition of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie]
synonym: "negative regulation of CD4-positive, alpha beta T cell costimulation" EXACT []
is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation
is_a: GO:2000524 ! negative regulation of T cell costimulation
relationship: negatively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation

[Term]
id: GO:1900281
name: positive regulation of CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie]
synonym: "activation of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie]
synonym: "positive regulation of CD4-positive, alpha beta T cell costimulation" EXACT []
synonym: "up regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "upregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000525 ! positive regulation of T cell costimulation
relationship: positively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation

[Term]
id: GO:1900282
name: regulation of cellobiose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000930 ! regulation of cellobiose metabolic process
relationship: regulates GO:2000892 ! cellobiose catabolic process

[Term]
id: GO:1900283
name: negative regulation of cellobiose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of cellobiose catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cellobiose catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:1900282 ! regulation of cellobiose catabolic process
is_a: GO:2000931 ! negative regulation of cellobiose metabolic process
relationship: negatively_regulates GO:2000892 ! cellobiose catabolic process

[Term]
id: GO:1900284
name: positive regulation of cellobiose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of cellobiose catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cellobiose catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellobiose catabolism" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1900282 ! regulation of cellobiose catabolic process
is_a: GO:2000932 ! positive regulation of cellobiose metabolic process
relationship: positively_regulates GO:2000892 ! cellobiose catabolic process

[Term]
id: GO:1900285
name: regulation of cellotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001096 ! cellotriose transport

[Term]
id: GO:1900286
name: negative regulation of cellotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of cellotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900285 ! regulation of cellotriose transport
relationship: negatively_regulates GO:2001096 ! cellotriose transport

[Term]
id: GO:1900287
name: positive regulation of cellotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of cellotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of cellotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900285 ! regulation of cellotriose transport
relationship: positively_regulates GO:2001096 ! cellotriose transport

[Term]
id: GO:1900288
name: regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
relationship: regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process

[Term]
id: GO:1900289
name: negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
relationship: negatively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process

[Term]
id: GO:1900290
name: positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
relationship: positively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process

[Term]
id: GO:1900291
name: regulation of galactotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001093 ! galactotriose transport

[Term]
id: GO:1900292
name: negative regulation of galactotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of galactotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900291 ! regulation of galactotriose transport
relationship: negatively_regulates GO:2001093 ! galactotriose transport

[Term]
id: GO:1900293
name: positive regulation of galactotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of galactotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of galactotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900291 ! regulation of galactotriose transport
relationship: positively_regulates GO:2001093 ! galactotriose transport

[Term]
id: GO:1900294
name: regulation of heptasaccharide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001104 ! heptasaccharide transport

[Term]
id: GO:1900295
name: negative regulation of heptasaccharide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of heptasaccharide transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900294 ! regulation of heptasaccharide transport
relationship: negatively_regulates GO:2001104 ! heptasaccharide transport

[Term]
id: GO:1900296
name: positive regulation of heptasaccharide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of heptasaccharide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of heptasaccharide transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900294 ! regulation of heptasaccharide transport
relationship: positively_regulates GO:2001104 ! heptasaccharide transport

[Term]
id: GO:1900297
name: regulation of hexasaccharide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001102 ! hexasaccharide transport

[Term]
id: GO:1900298
name: negative regulation of hexasaccharide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of hexasaccharide transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900297 ! regulation of hexasaccharide transport
relationship: negatively_regulates GO:2001102 ! hexasaccharide transport

[Term]
id: GO:1900299
name: positive regulation of hexasaccharide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of hexasaccharide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of hexasaccharide transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900297 ! regulation of hexasaccharide transport
relationship: positively_regulates GO:2001102 ! hexasaccharide transport

[Term]
id: GO:1900300
name: obsolete regulation of laminarabiose transport
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie]
comment: This term has been obsoleted because it does not represent an evolved process.
is_obsolete: true

[Term]
id: GO:1900301
name: obsolete negative regulation of laminarabiose transport
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie]
comment: This term has been obsoleted because it does not represent an evolved process.
synonym: "down regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of laminarabiose transport" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900302
name: obsolete positive regulation of laminarabiose transport
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie]
comment: This term has been obsoleted because it does not represent an evolved process.
synonym: "activation of laminarabiose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of laminarabiose transport" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900303
name: regulation of laminaritriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001097 ! laminaritriose transport

[Term]
id: GO:1900304
name: negative regulation of laminaritriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of laminaritriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900303 ! regulation of laminaritriose transport
relationship: negatively_regulates GO:2001097 ! laminaritriose transport

[Term]
id: GO:1900305
name: positive regulation of laminaritriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of laminaritriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of laminaritriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900303 ! regulation of laminaritriose transport
relationship: positively_regulates GO:2001097 ! laminaritriose transport

[Term]
id: GO:1900306
name: regulation of maltoheptaose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1900294 ! regulation of heptasaccharide transport
relationship: regulates GO:2001105 ! maltoheptaose transport

[Term]
id: GO:1900307
name: negative regulation of maltoheptaose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltoheptaose transport" NARROW [GOC:TermGenie]
is_a: GO:1900295 ! negative regulation of heptasaccharide transport
is_a: GO:1900306 ! regulation of maltoheptaose transport
relationship: negatively_regulates GO:2001105 ! maltoheptaose transport

[Term]
id: GO:1900308
name: positive regulation of maltoheptaose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltoheptaose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltoheptaose transport" EXACT [GOC:TermGenie]
is_a: GO:1900296 ! positive regulation of heptasaccharide transport
is_a: GO:1900306 ! regulation of maltoheptaose transport
relationship: positively_regulates GO:2001105 ! maltoheptaose transport

[Term]
id: GO:1900309
name: regulation of maltoheptaose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
relationship: regulates GO:2001122 ! maltoheptaose metabolic process

[Term]
id: GO:1900310
name: negative regulation of maltoheptaose metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of maltoheptaose metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of maltoheptaose metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1900309 ! regulation of maltoheptaose metabolic process
relationship: negatively_regulates GO:2001122 ! maltoheptaose metabolic process

[Term]
id: GO:1900311
name: positive regulation of maltoheptaose metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltoheptaose metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of maltoheptaose metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1900309 ! regulation of maltoheptaose metabolic process
relationship: positively_regulates GO:2001122 ! maltoheptaose metabolic process

[Term]
id: GO:1900312
name: regulation of maltohexaose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1900297 ! regulation of hexasaccharide transport
relationship: regulates GO:2001103 ! maltohexaose transport

[Term]
id: GO:1900313
name: negative regulation of maltohexaose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltohexaose transport" NARROW [GOC:TermGenie]
is_a: GO:1900298 ! negative regulation of hexasaccharide transport
is_a: GO:1900312 ! regulation of maltohexaose transport
relationship: negatively_regulates GO:2001103 ! maltohexaose transport

[Term]
id: GO:1900314
name: positive regulation of maltohexaose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltohexaose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltohexaose transport" EXACT [GOC:TermGenie]
is_a: GO:1900299 ! positive regulation of hexasaccharide transport
is_a: GO:1900312 ! regulation of maltohexaose transport
relationship: positively_regulates GO:2001103 ! maltohexaose transport

[Term]
id: GO:1900315
name: regulation of maltopentaose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1900360 ! regulation of pentasaccharide transport
relationship: regulates GO:2001101 ! maltopentaose transport

[Term]
id: GO:1900316
name: negative regulation of maltopentaose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltopentaose transport" NARROW [GOC:TermGenie]
is_a: GO:1900315 ! regulation of maltopentaose transport
is_a: GO:1900361 ! negative regulation of pentasaccharide transport
relationship: negatively_regulates GO:2001101 ! maltopentaose transport

[Term]
id: GO:1900317
name: positive regulation of maltopentaose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltopentaose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltopentaose transport" EXACT [GOC:TermGenie]
is_a: GO:1900315 ! regulation of maltopentaose transport
is_a: GO:1900362 ! positive regulation of pentasaccharide transport
relationship: positively_regulates GO:2001101 ! maltopentaose transport

[Term]
id: GO:1900318
name: regulation of methane biosynthetic process from dimethylamine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001129 ! methane biosynthetic process from dimethylamine

[Term]
id: GO:1900319
name: negative regulation of methane biosynthetic process from dimethylamine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie]
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine

[Term]
id: GO:1900320
name: positive regulation of methane biosynthetic process from dimethylamine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine

[Term]
id: GO:1900321
name: regulation of maltotetraose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001099 ! maltotetraose transport

[Term]
id: GO:1900322
name: negative regulation of maltotetraose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltotetraose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900321 ! regulation of maltotetraose transport
relationship: negatively_regulates GO:2001099 ! maltotetraose transport

[Term]
id: GO:1900323
name: positive regulation of maltotetraose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltotetraose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltotetraose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900321 ! regulation of maltotetraose transport
relationship: positively_regulates GO:2001099 ! maltotetraose transport

[Term]
id: GO:1900324
name: regulation of maltotriulose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001090 ! maltotriulose transport

[Term]
id: GO:1900325
name: negative regulation of maltotriulose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltotriulose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900324 ! regulation of maltotriulose transport
relationship: negatively_regulates GO:2001090 ! maltotriulose transport

[Term]
id: GO:1900326
name: positive regulation of maltotriulose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltotriulose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltotriulose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900324 ! regulation of maltotriulose transport
relationship: positively_regulates GO:2001090 ! maltotriulose transport

[Term]
id: GO:1900327
name: regulation of mannotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001095 ! mannotriose transport

[Term]
id: GO:1900328
name: negative regulation of mannotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of mannotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900327 ! regulation of mannotriose transport
relationship: negatively_regulates GO:2001095 ! mannotriose transport

[Term]
id: GO:1900329
name: positive regulation of mannotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of mannotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of mannotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900327 ! regulation of mannotriose transport
relationship: positively_regulates GO:2001095 ! mannotriose transport

[Term]
id: GO:1900330
name: regulation of methane biosynthetic process from trimethylamine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001130 ! methane biosynthetic process from trimethylamine

[Term]
id: GO:1900331
name: negative regulation of methane biosynthetic process from trimethylamine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie]
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine

[Term]
id: GO:1900332
name: positive regulation of methane biosynthetic process from trimethylamine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine

[Term]
id: GO:1900333
name: regulation of methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid

[Term]
id: GO:1900334
name: negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie]
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid

[Term]
id: GO:1900335
name: positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid

[Term]
id: GO:1900336
name: regulation of methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001134 ! methane biosynthetic process from carbon monoxide

[Term]
id: GO:1900337
name: negative regulation of methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie]
is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide

[Term]
id: GO:1900338
name: positive regulation of methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide

[Term]
id: GO:1900339
name: regulation of methane biosynthetic process from formic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001127 ! methane biosynthetic process from formic acid

[Term]
id: GO:1900340
name: negative regulation of methane biosynthetic process from formic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001127 ! methane biosynthetic process from formic acid

[Term]
id: GO:1900341
name: positive regulation of methane biosynthetic process from formic acid
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001127 ! methane biosynthetic process from formic acid

[Term]
id: GO:1900342
name: regulation of methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide

[Term]
id: GO:1900343
name: negative regulation of methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie]
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide

[Term]
id: GO:1900344
name: positive regulation of methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide

[Term]
id: GO:1900345
name: regulation of methane biosynthetic process from methanethiol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001133 ! methane biosynthetic process from methanethiol

[Term]
id: GO:1900346
name: negative regulation of methane biosynthetic process from methanethiol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie]
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001133 ! methane biosynthetic process from methanethiol

[Term]
id: GO:1900347
name: positive regulation of methane biosynthetic process from methanethiol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001133 ! methane biosynthetic process from methanethiol

[Term]
id: GO:1900348
name: regulation of methane biosynthetic process from methylamine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:2001128 ! methane biosynthetic process from methylamine

[Term]
id: GO:1900349
name: negative regulation of methane biosynthetic process from methylamine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie]
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
relationship: negatively_regulates GO:2001128 ! methane biosynthetic process from methylamine

[Term]
id: GO:1900350
name: positive regulation of methane biosynthetic process from methylamine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:2001128 ! methane biosynthetic process from methylamine

[Term]
id: GO:1900351
name: regulation of methanofuran biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
is_a: GO:1900354 ! regulation of methanofuran metabolic process
relationship: regulates GO:2001120 ! methanofuran biosynthetic process

[Term]
id: GO:1900352
name: negative regulation of methanofuran biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methanofuran biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045863 ! negative regulation of pteridine metabolic process
is_a: GO:1900351 ! regulation of methanofuran biosynthetic process
is_a: GO:1900355 ! negative regulation of methanofuran metabolic process
relationship: negatively_regulates GO:2001120 ! methanofuran biosynthetic process

[Term]
id: GO:1900353
name: positive regulation of methanofuran biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of methanofuran biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045864 ! positive regulation of pteridine metabolic process
is_a: GO:1900351 ! regulation of methanofuran biosynthetic process
is_a: GO:1900356 ! positive regulation of methanofuran metabolic process
relationship: positively_regulates GO:2001120 ! methanofuran biosynthetic process

[Term]
id: GO:1900354
name: regulation of methanofuran metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:2001119 ! methanofuran metabolic process

[Term]
id: GO:1900355
name: negative regulation of methanofuran metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methanofuran metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900354 ! regulation of methanofuran metabolic process
relationship: negatively_regulates GO:2001119 ! methanofuran metabolic process

[Term]
id: GO:1900356
name: positive regulation of methanofuran metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanofuran metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900354 ! regulation of methanofuran metabolic process
relationship: positively_regulates GO:2001119 ! methanofuran metabolic process

[Term]
id: GO:1900357
name: regulation of nigerotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001091 ! nigerotriose transport

[Term]
id: GO:1900358
name: negative regulation of nigerotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of nigerotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900357 ! regulation of nigerotriose transport
relationship: negatively_regulates GO:2001091 ! nigerotriose transport

[Term]
id: GO:1900359
name: positive regulation of nigerotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of nigerotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of nigerotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900357 ! regulation of nigerotriose transport
relationship: positively_regulates GO:2001091 ! nigerotriose transport

[Term]
id: GO:1900360
name: regulation of pentasaccharide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:2001100 ! pentasaccharide transport

[Term]
id: GO:1900361
name: negative regulation of pentasaccharide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of pentasaccharide transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900360 ! regulation of pentasaccharide transport
relationship: negatively_regulates GO:2001100 ! pentasaccharide transport

[Term]
id: GO:1900362
name: positive regulation of pentasaccharide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of pentasaccharide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of pentasaccharide transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900360 ! regulation of pentasaccharide transport
relationship: positively_regulates GO:2001100 ! pentasaccharide transport

[Term]
id: GO:1900363
name: obsolete regulation of mRNA polyadenylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900364
name: obsolete negative regulation of mRNA polyadenylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie]
comment: The reason for obsoletion is that this term was added in error.
synonym: "negative regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900365
name: obsolete positive regulation of mRNA polyadenylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841]
comment: The reason for obsoletion is that this term represents a molecular function.
synonym: "activation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "activation of mRNA polyadenylation" NARROW [GOC:TermGenie]
synonym: "activation of mRNA polyadenylylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900366
name: negative regulation of defense response to insect
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie]
synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "susceptibility to insect" RELATED []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:2000068 ! regulation of defense response to insect
relationship: negatively_regulates GO:0002213 ! defense response to insect

[Term]
id: GO:1900367
name: positive regulation of defense response to insect
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "activation of defense response to insect" NARROW [GOC:TermGenie]
synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:2000068 ! regulation of defense response to insect
relationship: positively_regulates GO:0002213 ! defense response to insect

[Term]
id: GO:1900368
name: regulation of post-transcriptional gene silencing by regulatory ncRNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-transcriptional gene silencing by a non-coding RNA." [GOC:kmv, GOC:TermGenie, PMID:22412382]
synonym: "regulation of post-transcriptional gene silencing by ncRNA" RELATED []
synonym: "regulation of post-transcriptional gene silencing by RNA" RELATED []
synonym: "regulation of PTGS" EXACT []
synonym: "regulation of RNA interference" EXACT []
synonym: "regulation of RNAi" EXACT [GOC:TermGenie]
is_a: GO:0060147 ! regulation of post-transcriptional gene silencing
is_a: GO:0060966 ! regulation of gene silencing by regulatory ncRNA
relationship: regulates GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:1900369
name: negative regulation of post-transcriptional gene silencing by regulatory ncRNA
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA." [GOC:kmv, GOC:TermGenie, PMID:22412382]
synonym: "down regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "down regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "downregulation of RNAi" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA interference" NARROW [GOC:TermGenie]
synonym: "inhibition of RNAi" EXACT [GOC:TermGenie]
synonym: "negative regulation of post-transcriptional gene silencing by ncRNA" RELATED []
synonym: "negative regulation of post-transcriptional gene silencing by RNA" RELATED []
synonym: "negative regulation of posttranscriptional gene silencing by siRNA" NARROW [GOC:TermGenie]
synonym: "negative regulation of PTGS" EXACT []
synonym: "negative regulation of RNA interference" EXACT []
synonym: "negative regulation of RNAi" EXACT [GOC:TermGenie]
is_a: GO:0060149 ! negative regulation of post-transcriptional gene silencing
is_a: GO:0060967 ! negative regulation of gene silencing by regulatory ncRNA
is_a: GO:1900368 ! regulation of post-transcriptional gene silencing by regulatory ncRNA
relationship: negatively_regulates GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:1900370
name: positive regulation of post-transcriptional gene silencing by RNA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-transcriptional gene silencing by RNA." [GOC:kmv, GOC:TermGenie, PMID:22412382]
synonym: "activation of RNA interference" NARROW [GOC:TermGenie]
synonym: "activation of RNAi" EXACT [GOC:TermGenie]
synonym: "positive regulation of PTGS" EXACT []
synonym: "positive regulation of RNA interference" EXACT []
synonym: "positive regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "up regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "upregulation of RNAi" EXACT [GOC:TermGenie]
is_a: GO:0060148 ! positive regulation of post-transcriptional gene silencing
is_a: GO:1900368 ! regulation of post-transcriptional gene silencing by regulatory ncRNA
relationship: positively_regulates GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:1900371
name: regulation of purine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie]
synonym: "regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
relationship: regulates GO:0006164 ! purine nucleotide biosynthetic process

[Term]
id: GO:1900372
name: negative regulation of purine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie]
synonym: "down regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
relationship: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process

[Term]
id: GO:1900373
name: positive regulation of purine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie]
synonym: "activation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process

[Term]
id: GO:1900374
name: obsolete positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:go_curators, GOC:TermGenie, PMID:8804308]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900375
name: obsolete positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of inositol biosynthetic process." [GOC:go_curators, GOC:TermGenie, PMID:2004420]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900376
name: regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
relationship: regulates GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:1900377
name: negative regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:1900378
name: positive regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:1900379
name: regulation of asperthecin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0036184 ! asperthecin biosynthetic process

[Term]
id: GO:1900380
name: negative regulation of asperthecin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperthecin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900379 ! regulation of asperthecin biosynthetic process
relationship: negatively_regulates GO:0036184 ! asperthecin biosynthetic process

[Term]
id: GO:1900381
name: positive regulation of asperthecin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of asperthecin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "activation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900379 ! regulation of asperthecin biosynthetic process
relationship: positively_regulates GO:0036184 ! asperthecin biosynthetic process

[Term]
id: GO:1900382
name: obsolete regulation of thiamine biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of thiamine biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16874521]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of thiamin biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine anabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine formation by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine synthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900383
name: regulation of synaptic plasticity by receptor localization to synapse
namespace: biological_process
def: "Any process that modulates synaptic plasticity, the ability of synapses to change as circumstances require, via receptor localization to the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. Processes may include receptor transport to, and/or maintenance at, the synapse." [GOC:kmv, GOC:TermGenie, PMID:22464329]
synonym: "regulation of synaptic plasticity by receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0097120 ! receptor localization to synapse

[Term]
id: GO:1900384
name: regulation of flavonol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie]
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
relationship: regulates GO:0051555 ! flavonol biosynthetic process

[Term]
id: GO:1900385
name: negative regulation of flavonol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of flavonol biosynthetic process" NARROW [GOC:TermGenie]
is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process
is_a: GO:1900384 ! regulation of flavonol biosynthetic process
relationship: negatively_regulates GO:0051555 ! flavonol biosynthetic process

[Term]
id: GO:1900386
name: positive regulation of flavonol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie]
synonym: "activation of flavonol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process
is_a: GO:1900384 ! regulation of flavonol biosynthetic process
relationship: positively_regulates GO:0051555 ! flavonol biosynthetic process

[Term]
id: GO:1900387
name: obsolete negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cell-cell adhesion." [GOC:BHF, GOC:TermGenie, PMID:15737616]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900388
name: obsolete regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of vesicle-mediated transport." [GOC:mah, GOC:TermGenie, PMID:18622392]
comment: This term was made obsolete because there is no evidence that vesicle-mediated transport is regulated transcriptionally.
synonym: "regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter" EXACT []
is_obsolete: true

[Term]
id: GO:1900389
name: obsolete regulation of glucose import by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of glucose import." [GOC:mah, GOC:TermGenie, PMID:18622392]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of glucose uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900391
name: obsolete regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cAMP-mediated signaling." [GOC:mah, GOC:TermGenie, PMID:15448137]
comment: The reason for obsoletion is that cAMP-mediated signaling is not mediated by transcription from RNA polII promoter.
synonym: "regulation of cAMP-mediated signalling by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900392
name: obsolete regulation of transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in regulation of transport." [GOC:mah, GOC:TermGenie, PMID:17446861]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900394
name: regulation of kojic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:2001317 ! kojic acid biosynthetic process

[Term]
id: GO:1900395
name: negative regulation of kojic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of kojic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900394 ! regulation of kojic acid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:2001317 ! kojic acid biosynthetic process

[Term]
id: GO:1900396
name: positive regulation of kojic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "activation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "activation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "activation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of kojic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "activation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900394 ! regulation of kojic acid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:2001317 ! kojic acid biosynthetic process

[Term]
id: GO:1900397
name: regulation of pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
relationship: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process

[Term]
id: GO:1900398
name: negative regulation of pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
relationship: negatively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process

[Term]
id: GO:1900399
name: positive regulation of pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
relationship: positively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process

[Term]
id: GO:1900400
name: obsolete regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:1900393
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion import." [GOC:mah, GOC:TermGenie, PMID:18622392]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of iron import by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of iron ion import by regulation of transcription from RNA polymerase II promoter" RELATED []
synonym: "regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter" BROAD []
is_obsolete: true
consider: GO:0006357
consider: GO:0033212

[Term]
id: GO:1900402
name: obsolete regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate metabolic process." [GOC:mah, GOC:TermGenie, PMID:16408318]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of carbohydrate metabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900403
name: obsolete negative regulation of cellular amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cellular amino acid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:17446861]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900404
name: obsolete positive regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of DNA repair." [GOC:mah, GOC:TermGenie, PMID:20299455]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0006281

[Term]
id: GO:1900405
name: obsolete regulation of cell separation after cytokinesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cell separation after cytokinesis." [GOC:mah, GOC:TermGenie, PMID:10491317, PMID:12665550]
synonym: "regulation of cytokinetic cell separation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900406
name: obsolete regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of conjugation with cellular fusion." [GOC:mah, GOC:TermGenie, PMID:1112904]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900407
name: regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1902882 ! regulation of response to oxidative stress
relationship: regulates GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:1900408
name: negative regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "down regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "down regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1902883 ! negative regulation of response to oxidative stress
relationship: negatively_regulates GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:1900409
name: positive regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "activation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "upregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1902884 ! positive regulation of response to oxidative stress
relationship: positively_regulates GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:1900410
name: obsolete regulation of histone modification by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone modification." [GOC:mah, GOC:TermGenie]
comment: This term was obsoleted because it describes a process that does not exist.
is_obsolete: true

[Term]
id: GO:1900411
name: obsolete regulation of histone acetylation by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone acetylation." [GOC:mah, GOC:TermGenie, PMID:15218150]
comment: This term was obsoleted because it describes a process that does not exist.
is_obsolete: true

[Term]
id: GO:1900412
name: obsolete regulation of histone methylation by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone methylation." [GOC:mah, GOC:TermGenie, PMID:15218150]
comment: This term was obsoleted because it describes a process that does not exist.
is_obsolete: true

[Term]
id: GO:1900413
name: obsolete positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of phospholipid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16537923]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of phospholipid biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phospholipid synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900414
name: obsolete regulation of cytokinesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cytokinesis." [GOC:mah, GOC:TermGenie, PMID:15509866]
is_obsolete: true

[Term]
id: GO:1900415
name: obsolete regulation of fungal-type cell wall biogenesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of fungal-type cell wall biogenesis." [GOC:mah, GOC:TermGenie, PMID:15509866]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900416
name: obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of 4,6-pyruvylated galactose residue biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:15173185]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900417
name: obsolete negative regulation of transmembrane transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of transmembrane transport." [GOC:mah, GOC:TermGenie, PMID:20404084]
comment: The term was obsoleted because it is better represented by a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900418
name: obsolete positive regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of purine nucleotide biosynthetic process." [GOC:curators, GOC:TermGenie, PMID:17573544]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900419
name: regulation of alcohol catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alcohol catabolic process within a cell." [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0046164 ! alcohol catabolic process

[Term]
id: GO:1900420
name: negative regulation of alcohol catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of  alcohol catabolic process within a cell." [GOC:TermGenie]
synonym: "down regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular alcohol catabolic process" NARROW [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900419 ! regulation of alcohol catabolic process
relationship: negatively_regulates GO:0046164 ! alcohol catabolic process

[Term]
id: GO:1900421
name: positive regulation of alcohol catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alcohol catabolic process within a cell." [GOC:TermGenie]
synonym: "activation of cellular alcohol catabolic process" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900419 ! regulation of alcohol catabolic process
relationship: positively_regulates GO:0046164 ! alcohol catabolic process

[Term]
id: GO:1900422
name: obsolete positive regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of cellular alcohol catabolic process." [GOC:curators, GOC:TermGenie, PMID:3305157, PMID:8221926]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900423
name: obsolete positive regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:TermGenie, PMID:8804308]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900424
name: regulation of defense response to bacterium
namespace: biological_process
alt_id: GO:1902477
def: "Any process that modulates the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "regulation of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "regulation of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to bacterium, incompatible interaction" NARROW []
synonym: "regulation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "regulation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0042742 ! defense response to bacterium

[Term]
id: GO:1900425
name: negative regulation of defense response to bacterium
namespace: biological_process
alt_id: GO:1902478
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "down regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "down regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "down regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "down regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "down regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "down-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "down-regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "downregulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "downregulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "downregulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "inhibition of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "inhibition of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "inhibition of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "inhibition of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to bacterium" NARROW [GOC:TermGenie]
synonym: "inhibition of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "inhibition of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
synonym: "inhibition of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "inhibition of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "negative regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "negative regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "negative regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "negative regulation of defense response to bacterium, incompatible interaction" NARROW []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:1900424 ! regulation of defense response to bacterium
relationship: negatively_regulates GO:0042742 ! defense response to bacterium

[Term]
id: GO:1900426
name: positive regulation of defense response to bacterium
namespace: biological_process
alt_id: GO:1902479
def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "activation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "activation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "activation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "activation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "activation of defense response to bacterium" NARROW [GOC:TermGenie]
synonym: "activation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "activation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
synonym: "positive regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of defense response to bacterium, incompatible interaction" NARROW []
synonym: "up regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "upregulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to bacterium" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:1900424 ! regulation of defense response to bacterium
relationship: positively_regulates GO:0042742 ! defense response to bacterium

[Term]
id: GO:1900427
name: obsolete regulation of cellular response to oxidative stress by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie, PMID:10348908]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of adaptive response to oxidative stress by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900428
name: regulation of filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie]
is_a: GO:0010570 ! regulation of filamentous growth
relationship: regulates GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:1900429
name: negative regulation of filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie]
is_a: GO:0060258 ! negative regulation of filamentous growth
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: negatively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:1900430
name: positive regulation of filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
is_a: GO:0090033 ! positive regulation of filamentous growth
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: positively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:1900431
name: regulation of filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie]
is_a: GO:0080134 ! regulation of response to stress
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat

[Term]
id: GO:1900432
name: negative regulation of filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat
relationship: negatively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat

[Term]
id: GO:1900433
name: positive regulation of filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat
relationship: positively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat

[Term]
id: GO:1900434
name: regulation of filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080134 ! regulation of response to stress
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation

[Term]
id: GO:1900435
name: obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900436
name: positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900434 ! regulation of filamentous growth of a population of unicellular organisms in response to starvation
relationship: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation

[Term]
id: GO:1900437
name: regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus

[Term]
id: GO:1900438
name: negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
relationship: negatively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus

[Term]
id: GO:1900439
name: positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
relationship: positively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus

[Term]
id: GO:1900440
name: regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie]
is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH
relationship: regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH

[Term]
id: GO:1900441
name: negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie]
is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
is_a: GO:1900742 ! negative regulation of filamentous growth of a population of unicellular organisms in response to pH
relationship: negatively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH

[Term]
id: GO:1900442
name: positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
is_a: GO:1900743 ! positive regulation of filamentous growth of a population of unicellular organisms in response to pH
relationship: positively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH

[Term]
id: GO:1900443
name: regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus

[Term]
id: GO:1900444
name: negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
relationship: negatively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus

[Term]
id: GO:1900445
name: positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
relationship: positively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus

[Term]
id: GO:1900446
name: obsolete negative regulation of tRNA transcription from RNA polymerase III promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of tRNA transcription from RNA polymerase III promoter." [GOC:sart, GOC:TermGenie]
comment: The reason for obsoletion is that there is no specific regulator for negatively regulating tRNA transcription which is separable from general negative regulation of transcription from RNA polymerase III.
synonym: "down regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900447
name: regulation of cell morphogenesis involved in phenotypic switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing a phenotypic switch. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells, such as the opaque cells of C. albicans, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:di, GOC:TermGenie]
synonym: "negative regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie]
synonym: "regulation of cell morphogenesis of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of cell morphogenesis of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie]
is_a: GO:0022604 ! regulation of cell morphogenesis
relationship: part_of GO:0036166 ! phenotypic switching

[Term]
id: GO:1900448
name: obsolete regulation of pyrimidine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900449
name: regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007215 ! glutamate receptor signaling pathway

[Term]
id: GO:1900450
name: negative regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
relationship: negatively_regulates GO:0007215 ! glutamate receptor signaling pathway

[Term]
id: GO:1900451
name: positive regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of glutamate receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
relationship: positively_regulates GO:0007215 ! glutamate receptor signaling pathway

[Term]
id: GO:1900452
name: regulation of long-term synaptic depression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "regulation of long term synaptic depression" EXACT []
synonym: "regulation of LTD" RELATED [GOC:TermGenie]
is_a: GO:0048167 ! regulation of synaptic plasticity
relationship: regulates GO:0060292 ! long-term synaptic depression

[Term]
id: GO:1900453
name: negative regulation of long-term synaptic depression
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "down regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "down regulation of LTD" RELATED [GOC:TermGenie]
synonym: "down-regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "down-regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "down-regulation of LTD" RELATED [GOC:TermGenie]
synonym: "downregulation of long term depression" BROAD [GOC:TermGenie]
synonym: "downregulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "downregulation of LTD" RELATED [GOC:TermGenie]
synonym: "inhibition of long term depression" BROAD [GOC:TermGenie]
synonym: "inhibition of long term synaptic depression" NARROW [GOC:TermGenie]
synonym: "inhibition of LTD" RELATED [GOC:TermGenie]
synonym: "negative regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "negative regulation of long term synaptic depression" RELATED []
synonym: "negative regulation of LTD" RELATED [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900452 ! regulation of long-term synaptic depression
relationship: negatively_regulates GO:0060292 ! long-term synaptic depression

[Term]
id: GO:1900454
name: positive regulation of long-term synaptic depression
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie]
synonym: "activation of long term depression" BROAD [GOC:TermGenie]
synonym: "activation of long term synaptic depression" NARROW [GOC:TermGenie]
synonym: "activation of LTD" RELATED [GOC:TermGenie]
synonym: "positive regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "positive regulation of long term synaptic depression" EXACT []
synonym: "positive regulation of LTD" RELATED [GOC:TermGenie]
synonym: "up regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "up regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "up regulation of LTD" RELATED [GOC:TermGenie]
synonym: "up-regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "up-regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "up-regulation of LTD" RELATED [GOC:TermGenie]
synonym: "upregulation of long term depression" BROAD [GOC:TermGenie]
synonym: "upregulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "upregulation of LTD" RELATED [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1900452 ! regulation of long-term synaptic depression
relationship: positively_regulates GO:0060292 ! long-term synaptic depression

[Term]
id: GO:1900456
name: obsolete regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10373537, PMID:10591965, PMID:12024013, PMID:15466424, PMID:16568252, PMID:8710886, PMID:9811878, PMID:9987114]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of colony morphology by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter" EXACT []
is_obsolete: true

[Term]
id: GO:1900457
name: regulation of brassinosteroid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796]
synonym: "regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0009742 ! brassinosteroid mediated signaling pathway

[Term]
id: GO:1900458
name: negative regulation of brassinosteroid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796]
synonym: "down regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "down-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "downregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "inhibition of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway
relationship: negatively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway

[Term]
id: GO:1900459
name: positive regulation of brassinosteroid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796]
synonym: "activation of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "positive regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway
relationship: positively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway

[Term]
id: GO:1900460
name: obsolete negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024013, PMID:15466424, PMID:9811878]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of colony morphology by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900461
name: positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114]
is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II
is_a: GO:2000222 ! positive regulation of pseudohyphal growth

[Term]
id: GO:1900462
name: obsolete negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024012, PMID:9811878]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900463
name: obsolete negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular response to alkalinity by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of cellular response to alkalinity by negative regulation of transcription from RNA polymerase II promoter" BROAD []
synonym: "negative regulation of cellular response to basic pH by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122
consider: GO:0071469

[Term]
id: GO:1900464
name: obsolete negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular hyperosmotic salinity response by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:16278455]
comment: This term was obsoleted because it represents a GO-CAM model
synonym: "negative regulation of cellular response to hyperosmotic salt stress by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122
consider: GO:0071475

[Term]
id: GO:1900465
name: obsolete negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular arginine catabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of arginine breakdown by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine catabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine degradation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900466
name: obsolete positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900467
name: obsolete regulation of cellular potassium ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cellular potassium ion homeostasis." [GOC:dgf, GOC:TermGenie, PMID:20412803]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cellular potassium ion homeostasis" EXACT []
is_obsolete: true

[Term]
id: GO:1900468
name: regulation of phosphatidylserine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:0150178 ! regulation of phosphatidylserine metabolic process
relationship: regulates GO:0006659 ! phosphatidylserine biosynthetic process

[Term]
id: GO:1900469
name: negative regulation of phosphatidylserine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "down regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:0150180 ! negative regulation of phosphatidylserine metabolic process
is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process
relationship: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process

[Term]
id: GO:1900470
name: positive regulation of phosphatidylserine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "activation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:0150179 ! positive regulation of phosphatidylserine metabolic process
is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process
relationship: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process

[Term]
id: GO:1900471
name: obsolete negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of inositol biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of inositol anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900472
name: obsolete positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of phosphatidylcholine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900473
name: obsolete negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of phosphatidylcholine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900474
name: obsolete negative regulation of mating type switching by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8625408, PMID:8625409]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1900477
name: obsolete negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19841732]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:2000134

[Term]
id: GO:1900478
name: obsolete positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of sulfate assimilation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:7601277, PMID:7891681]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900480
name: regulation of diacylglycerol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie]
synonym: "regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0006651 ! diacylglycerol biosynthetic process

[Term]
id: GO:1900481
name: negative regulation of diacylglycerol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process
relationship: negatively_regulates GO:0006651 ! diacylglycerol biosynthetic process

[Term]
id: GO:1900482
name: positive regulation of diacylglycerol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie]
synonym: "activation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "activation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process
relationship: positively_regulates GO:0006651 ! diacylglycerol biosynthetic process

[Term]
id: GO:1900483
name: regulation of protein targeting to vacuolar membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0090313 ! regulation of protein targeting to membrane
is_a: GO:1903335 ! regulation of vacuolar transport
relationship: regulates GO:0044395 ! protein targeting to vacuolar membrane

[Term]
id: GO:1900484
name: negative regulation of protein targeting to vacuolar membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie]
synonym: "down regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie]
is_a: GO:0090315 ! negative regulation of protein targeting to membrane
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane
is_a: GO:1903336 ! negative regulation of vacuolar transport
relationship: negatively_regulates GO:0044395 ! protein targeting to vacuolar membrane

[Term]
id: GO:1900485
name: positive regulation of protein targeting to vacuolar membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie]
synonym: "activation of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie]
synonym: "up regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
is_a: GO:0090314 ! positive regulation of protein targeting to membrane
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane
is_a: GO:1903337 ! positive regulation of vacuolar transport
relationship: positively_regulates GO:0044395 ! protein targeting to vacuolar membrane

[Term]
id: GO:1900486
name: positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:TermGenie]
synonym: "activation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "activation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" NARROW [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
relationship: positively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway

[Term]
id: GO:1900487
name: regulation of [2Fe-2S] cluster assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
relationship: regulates GO:0044571 ! [2Fe-2S] cluster assembly

[Term]
id: GO:1900488
name: negative regulation of [2Fe-2S] cluster assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly
is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly
relationship: negatively_regulates GO:0044571 ! [2Fe-2S] cluster assembly

[Term]
id: GO:1900489
name: positive regulation of [2Fe-2S] cluster assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "activation of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly
is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly
relationship: positively_regulates GO:0044571 ! [2Fe-2S] cluster assembly

[Term]
id: GO:1900490
name: obsolete positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:TermGenie]
comment: This term has been obsoleted because it represents a molecular function.
synonym: "activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "activation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "activation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "positive regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "up regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "up regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "up regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "up-regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "up-regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "upregulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "upregulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0008047
consider: GO:0106109

[Term]
id: GO:1900491
name: regulation of [4Fe-4S] cluster assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
relationship: regulates GO:0044572 ! [4Fe-4S] cluster assembly

[Term]
id: GO:1900492
name: negative regulation of [4Fe-4S] cluster assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "down regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly
is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly
relationship: negatively_regulates GO:0044572 ! [4Fe-4S] cluster assembly

[Term]
id: GO:1900493
name: positive regulation of [4Fe-4S] cluster assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "activation of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly
is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly
relationship: positively_regulates GO:0044572 ! [4Fe-4S] cluster assembly

[Term]
id: GO:1900494
name: regulation of butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process
relationship: regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA

[Term]
id: GO:1900495
name: negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie]
synonym: "negative regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA
relationship: negatively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA

[Term]
id: GO:1900496
name: positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie]
synonym: "positive regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA
relationship: positively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA

[Term]
id: GO:1900497
name: regulation of butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol

[Term]
id: GO:1900498
name: negative regulation of butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "negative regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol

[Term]
id: GO:1900499
name: positive regulation of butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "positive regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol

[Term]
id: GO:1900500
name: regulation of butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate

[Term]
id: GO:1900501
name: negative regulation of butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "negative regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate
relationship: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate

[Term]
id: GO:1900502
name: positive regulation of butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "positive regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate
relationship: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate

[Term]
id: GO:1900503
name: regulation of cellulosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0044575 ! cellulosome assembly

[Term]
id: GO:1900504
name: negative regulation of cellulosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cellulosome assembly" NARROW [GOC:TermGenie]
is_a: GO:1900503 ! regulation of cellulosome assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0044575 ! cellulosome assembly

[Term]
id: GO:1900505
name: positive regulation of cellulosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of cellulosome assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cellulosome assembly" EXACT [GOC:TermGenie]
is_a: GO:1900503 ! regulation of cellulosome assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0044575 ! cellulosome assembly

[Term]
id: GO:1900506
name: regulation of iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
relationship: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly

[Term]
id: GO:1900507
name: negative regulation of iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly
is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly
relationship: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly

[Term]
id: GO:1900508
name: positive regulation of iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "activation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "activation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly
is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly
relationship: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly

[Term]
id: GO:1900509
name: obsolete regulation of pentose catabolic process to ethanol
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900510
name: obsolete negative regulation of pentose catabolic process to ethanol
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "down regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "inhibition of pentose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "inhibition of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "negative regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900511
name: obsolete positive regulation of pentose catabolic process to ethanol
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "activation of pentose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "activation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "positive regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900512
name: regulation of starch utilization system complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "regulation of SUS complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0044574 ! starch utilization system complex assembly

[Term]
id: GO:1900513
name: negative regulation of starch utilization system complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "down regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "downregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "inhibition of starch utilization system complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "negative regulation of SUS complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1900512 ! regulation of starch utilization system complex assembly
relationship: negatively_regulates GO:0044574 ! starch utilization system complex assembly

[Term]
id: GO:1900514
name: positive regulation of starch utilization system complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "activation of starch utilization system complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "positive regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "up regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "upregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of SUS complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1900512 ! regulation of starch utilization system complex assembly
relationship: positively_regulates GO:0044574 ! starch utilization system complex assembly

[Term]
id: GO:1900515
name: regulation of xylose catabolic process to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0043465 ! regulation of fermentation
is_a: GO:0043469 ! regulation of D-xylose catabolic process
relationship: regulates GO:0044577 ! D-xylose catabolic process to ethanol

[Term]
id: GO:1900516
name: negative regulation of xylose catabolic process to ethanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "inhibition of xylose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "inhibition of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "negative regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol
is_a: GO:1901003 ! negative regulation of fermentation
relationship: negatively_regulates GO:0044577 ! D-xylose catabolic process to ethanol

[Term]
id: GO:1900517
name: positive regulation of xylose catabolic process to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of xylose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "activation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "positive regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol
relationship: positively_regulates GO:0044577 ! D-xylose catabolic process to ethanol

[Term]
id: GO:1900518
name: regulation of response to pullulan
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0044592 ! response to pullulan

[Term]
id: GO:1900519
name: negative regulation of response to pullulan
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "downregulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "inhibition of response to pullulan" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900518 ! regulation of response to pullulan
relationship: negatively_regulates GO:0044592 ! response to pullulan

[Term]
id: GO:1900520
name: positive regulation of response to pullulan
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to pullulan" NARROW [GOC:TermGenie]
synonym: "up regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "upregulation of response to pullulan" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900518 ! regulation of response to pullulan
relationship: positively_regulates GO:0044592 ! response to pullulan

[Term]
id: GO:1900521
name: regulation of response to amylopectin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0044591 ! response to amylopectin

[Term]
id: GO:1900522
name: negative regulation of response to amylopectin
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "downregulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "inhibition of response to amylopectin" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900521 ! regulation of response to amylopectin
relationship: negatively_regulates GO:0044591 ! response to amylopectin

[Term]
id: GO:1900523
name: positive regulation of response to amylopectin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to amylopectin" NARROW [GOC:TermGenie]
synonym: "up regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "upregulation of response to amylopectin" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900521 ! regulation of response to amylopectin
relationship: positively_regulates GO:0044591 ! response to amylopectin

[Term]
id: GO:1900524
name: obsolete positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252]
comment: This term was obsoleted because it represents a GO-CAM.
synonym: "activation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900525
name: obsolete positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900526
name: obsolete negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of phosphatidylserine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900527
name: obsolete regulation of nucleus size involved in G1 to G0 transition
namespace: biological_process
def: "OBSOLETE. Any regulation of nucleus size that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728]
comment: This term was made obsolete because it represents a phenotype.
synonym: "regulation of nuclear size involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear size involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear size involved in G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear size involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear size involved in stationary phase" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in stationary phase" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus size involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus size involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of nucleus size involved in G1 to G0 transition" EXACT []
synonym: "regulation of nucleus size involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nucleus size involved in stationary phase" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900528
name: obsolete regulation of cell shape involved in G1 to G0 transition
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728]
comment: This term was made obsolete because it represents a phenotype.
synonym: "regulation of cell shape involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of cell shape involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape involved in G1 to G0 transition" EXACT []
synonym: "regulation of cell shape involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape involved in stationary phase" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900529
name: obsolete regulation of cell shape involved in cellular response to glucose starvation
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to glucose starvation." [GOC:al, GOC:TermGenie, PMID:9135147]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell shape involved in cellular response to glucose starvation" EXACT []
is_obsolete: true

[Term]
id: GO:1900530
name: obsolete regulation of cell shape involved in cellular response to salt stress
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to salt stress." [GOC:al, GOC:TermGenie, PMID:9135147]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell shape involved in cellular response to salt stress" EXACT []
synonym: "regulation of cell shape of cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape of cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape of cellular salinity response" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900531
name: obsolete regulation of cell shape involved in cellular response to heat
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to heat." [GOC:al, GOC:TermGenie, PMID:9135147]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell shape involved in cellular response to heat" EXACT []
synonym: "regulation of cell shape of cellular response to heat" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape of cellular response to heat stress" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900532
name: obsolete negative regulation of cell proliferation involved in cellular hyperosmotic response
namespace: biological_process
def: "OBSOLETE. Negative regulation of cell proliferation during cellular hyperosmotic response." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular HOG response" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular hyperosmotic response" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular hypertonic response" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular response to hypertonicity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell proliferation involved in cellular hyperosmotic response" EXACT []
synonym: "negative regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900533
name: palmitic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving palmitic acid." [GOC:TermGenie]
is_a: GO:0001676 ! long-chain fatty acid metabolic process

[Term]
id: GO:1900534
name: palmitic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of palmitic acid." [GOC:TermGenie]
is_a: GO:0042758 ! long-chain fatty acid catabolic process
is_a: GO:1900533 ! palmitic acid metabolic process

[Term]
id: GO:1900535
name: palmitic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of palmitic acid." [GOC:TermGenie]
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1900533 ! palmitic acid metabolic process

[Term]
id: GO:1900536
name: obsolete regulation of glucose homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of glucose homeostasis" EXACT []
is_obsolete: true

[Term]
id: GO:1900537
name: obsolete negative regulation of glucose homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of glucose homeostasis" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucose homeostasis" EXACT []
is_obsolete: true

[Term]
id: GO:1900538
name: obsolete positive regulation of glucose homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of glucose homeostasis" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucose homeostasis" EXACT []
synonym: "up regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900539
name: fumonisin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumonisin." [GOC:TermGenie]
synonym: "fumonisin metabolism" RELATED []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:1900540
name: fumonisin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumonisin." [GOC:TermGenie]
synonym: "fumonisin breakdown" EXACT []
synonym: "fumonisin catabolism" EXACT []
synonym: "fumonisin degradation" RELATED []
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900539 ! fumonisin metabolic process

[Term]
id: GO:1900541
name: fumonisin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumonisin." [GOC:TermGenie]
synonym: "fumonisin anabolism" EXACT []
synonym: "fumonisin biosynthesis" EXACT []
synonym: "fumonisin formation" EXACT []
synonym: "fumonisin synthesis" EXACT []
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900539 ! fumonisin metabolic process

[Term]
id: GO:1900542
name: regulation of purine nucleotide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]
synonym: "regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006140 ! regulation of nucleotide metabolic process
relationship: regulates GO:0006163 ! purine nucleotide metabolic process

[Term]
id: GO:1900543
name: negative regulation of purine nucleotide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]
synonym: "down regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "down regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "down regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "downregulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "downregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of purine metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of purine nucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of purine nucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
relationship: negatively_regulates GO:0006163 ! purine nucleotide metabolic process

[Term]
id: GO:1900544
name: positive regulation of purine nucleotide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]
synonym: "activation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "up regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "up regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "upregulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "upregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
relationship: positively_regulates GO:0006163 ! purine nucleotide metabolic process

[Term]
id: GO:1900545
name: obsolete regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of phenotypic switching." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900546
name: obsolete positive regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of phenotypic switching." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "activation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up-regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "upregulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900547
name: obsolete negative regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of phenotypic switching." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900548
name: heme B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:TermGenie, GOC:yaf, PMID:28352909]
synonym: "heme B breakdown" EXACT [GOC:TermGenie]
synonym: "heme B catabolism" EXACT [GOC:TermGenie]
synonym: "heme B degradation" EXACT [GOC:TermGenie]
synonym: "protoheme catabolic process" EXACT []
synonym: "protoheme degradation" EXACT []
xref: MetaCyc:PWY-5874
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046492 ! heme B metabolic process

[Term]
id: GO:1900549
name: N',N'',N'''-triacetylfusarinine C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900550
name: N',N'',N'''-triacetylfusarinine C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C breakdown" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C catabolism" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process

[Term]
id: GO:1900551
name: N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process

[Term]
id: GO:1900552
name: asperfuranone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asperfuranone." [GOC:di, GOC:TermGenie]
synonym: "asperfuranone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:1900553
name: asperfuranone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of asperfuranone." [GOC:di, GOC:TermGenie]
synonym: "asperfuranone breakdown" EXACT [GOC:TermGenie]
synonym: "asperfuranone catabolism" EXACT [GOC:TermGenie]
synonym: "asperfuranone degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1900552 ! asperfuranone metabolic process

[Term]
id: GO:1900554
name: asperfuranone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asperfuranone." [GOC:di, GOC:TermGenie]
synonym: "asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1900552 ! asperfuranone metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:1900555
name: emericellamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emericellamide." [GOC:di, GOC:TermGenie]
synonym: "emericellamide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0050761 ! depsipeptide metabolic process
is_a: GO:0072338 ! lactam metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:1900556
name: emericellamide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emericellamide." [GOC:di, GOC:TermGenie]
synonym: "emericellamide breakdown" EXACT [GOC:TermGenie]
synonym: "emericellamide catabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide degradation" EXACT [GOC:TermGenie]
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0050762 ! depsipeptide catabolic process
is_a: GO:0072340 ! lactam catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900555 ! emericellamide metabolic process
is_a: GO:1901335 ! lactone catabolic process

[Term]
id: GO:1900557
name: emericellamide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emericellamide." [GOC:di, GOC:TermGenie]
synonym: "emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "emericellamide formation" EXACT [GOC:TermGenie]
synonym: "emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0050763 ! depsipeptide biosynthetic process
is_a: GO:0072339 ! lactam biosynthetic process
is_a: GO:1900555 ! emericellamide metabolic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:1900558
name: austinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving austinol." [GOC:di, GOC:TermGenie]
synonym: "austinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1900559
name: austinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of austinol." [GOC:di, GOC:TermGenie]
synonym: "austinol breakdown" EXACT [GOC:TermGenie]
synonym: "austinol catabolism" EXACT [GOC:TermGenie]
synonym: "austinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1900558 ! austinol metabolic process

[Term]
id: GO:1900560
name: austinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of austinol." [GOC:di, GOC:TermGenie]
synonym: "austinol anabolism" EXACT [GOC:TermGenie]
synonym: "austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "austinol formation" EXACT [GOC:TermGenie]
synonym: "austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1900558 ! austinol metabolic process

[Term]
id: GO:1900561
name: dehydroaustinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dehydroaustinol." [GOC:di, GOC:TermGenie]
synonym: "dehydroaustinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900562
name: dehydroaustinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dehydroaustinol." [GOC:di, GOC:TermGenie]
synonym: "dehydroaustinol breakdown" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol catabolism" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900561 ! dehydroaustinol metabolic process

[Term]
id: GO:1900563
name: dehydroaustinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dehydroaustinol." [GOC:di, GOC:TermGenie]
synonym: "dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900561 ! dehydroaustinol metabolic process

[Term]
id: GO:1900564
name: chanoclavine-I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chanoclavine-I." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I metabolism" EXACT [GOC:TermGenie]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0035836 ! ergot alkaloid metabolic process

[Term]
id: GO:1900565
name: obsolete chanoclavine-I catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chanoclavine-I." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "chanoclavine-I breakdown" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I catabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900566
name: obsolete chanoclavine-I biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of chanoclavine-I." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1900809

[Term]
id: GO:1900567
name: chanoclavine-I aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I aldehyde metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006081 ! aldehyde metabolic process
is_a: GO:0035836 ! ergot alkaloid metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:1900568
name: obsolete chanoclavine-I aldehyde catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "chanoclavine-I aldehyde breakdown" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde catabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900569
name: chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde. Chanoclavine-I aldehyde is at a branching point in the biosynthetic pathways of fumigaclavine C and ergotamine." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:0035837 ! ergot alkaloid biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1900567 ! chanoclavine-I aldehyde metabolic process

[Term]
id: GO:1900570
name: diorcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diorcinol." [GOC:di, GOC:TermGenie]
synonym: "diorcinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900571
name: diorcinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diorcinol." [GOC:di, GOC:TermGenie]
synonym: "diorcinol breakdown" EXACT [GOC:TermGenie]
synonym: "diorcinol catabolism" EXACT [GOC:TermGenie]
synonym: "diorcinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900570 ! diorcinol metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1900572
name: diorcinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diorcinol." [GOC:di, GOC:TermGenie]
synonym: "diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "diorcinol formation" EXACT [GOC:TermGenie]
synonym: "diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900570 ! diorcinol metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1900573
name: emodin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emodin." [GOC:di, GOC:TermGenie]
synonym: "emodin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1900574
name: emodin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emodin." [GOC:di, GOC:TermGenie]
synonym: "emodin breakdown" EXACT [GOC:TermGenie]
synonym: "emodin catabolism" EXACT [GOC:TermGenie]
synonym: "emodin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900573 ! emodin metabolic process

[Term]
id: GO:1900575
name: emodin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emodin." [GOC:di, GOC:TermGenie]
synonym: "emodin anabolism" EXACT [GOC:TermGenie]
synonym: "emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "emodin formation" EXACT [GOC:TermGenie]
synonym: "emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900573 ! emodin metabolic process

[Term]
id: GO:1900576
name: gerfelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gerfelin." [GOC:di, GOC:TermGenie]
synonym: "gerfelin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:1900577
name: gerfelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gerfelin." [GOC:di, GOC:TermGenie]
synonym: "gerfelin breakdown" EXACT [GOC:TermGenie]
synonym: "gerfelin catabolism" EXACT [GOC:TermGenie]
synonym: "gerfelin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900576 ! gerfelin metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1900578
name: gerfelin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gerfelin." [GOC:di, GOC:TermGenie]
synonym: "gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "gerfelin formation" EXACT [GOC:TermGenie]
synonym: "gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900576 ! gerfelin metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1900579
name: (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:1900580
name: (17Z)-protosta-17(20),24-dien-3beta-ol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol breakdown" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol catabolism" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol degradation" EXACT [GOC:TermGenie]
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016105 ! triterpenoid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process

[Term]
id: GO:1900581
name: (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol anabolism" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol formation" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0010686 ! tetracyclic triterpenoid biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:1900582
name: o-orsellinic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving o-orsellinic acid." [GOC:di, GOC:TermGenie]
synonym: "o-orsellinic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:1900583
name: o-orsellinic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of o-orsellinic acid." [GOC:di, GOC:TermGenie]
synonym: "o-orsellinic acid breakdown" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid catabolism" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900582 ! o-orsellinic acid metabolic process

[Term]
id: GO:1900584
name: o-orsellinic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of o-orsellinic acid." [GOC:di, GOC:TermGenie]
synonym: "o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900582 ! o-orsellinic acid metabolic process

[Term]
id: GO:1900585
name: arugosin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arugosin." [GOC:di, GOC:TermGenie]
synonym: "arugosin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900586
name: arugosin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arugosin." [GOC:di, GOC:TermGenie]
synonym: "arugosin breakdown" EXACT [GOC:TermGenie]
synonym: "arugosin catabolism" EXACT [GOC:TermGenie]
synonym: "arugosin degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900585 ! arugosin metabolic process

[Term]
id: GO:1900587
name: arugosin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arugosin." [GOC:di, GOC:TermGenie]
synonym: "arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "arugosin formation" EXACT [GOC:TermGenie]
synonym: "arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900585 ! arugosin metabolic process

[Term]
id: GO:1900588
name: violaceol I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving violaceol I." [GOC:di, GOC:TermGenie]
synonym: "violaceol I metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900589
name: violaceol I catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of violaceol I." [GOC:di, GOC:TermGenie]
synonym: "violaceol I breakdown" EXACT [GOC:TermGenie]
synonym: "violaceol I catabolism" EXACT [GOC:TermGenie]
synonym: "violaceol I degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900588 ! violaceol I metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1900590
name: violaceol I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of violaceol I." [GOC:di, GOC:TermGenie]
synonym: "violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "violaceol I formation" EXACT [GOC:TermGenie]
synonym: "violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900588 ! violaceol I metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1900591
name: violaceol II metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving violaceol II." [GOC:di, GOC:TermGenie]
synonym: "violaceol II metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900592
name: violaceol II catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of violaceol II." [GOC:di, GOC:TermGenie]
synonym: "violaceol II breakdown" EXACT [GOC:TermGenie]
synonym: "violaceol II catabolism" EXACT [GOC:TermGenie]
synonym: "violaceol II degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900591 ! violaceol II metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1900593
name: violaceol II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of violaceol II." [GOC:di, GOC:TermGenie]
synonym: "violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "violaceol II formation" EXACT [GOC:TermGenie]
synonym: "violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900591 ! violaceol II metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1900594
name: (+)-kotanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-kotanin." [GOC:di, GOC:TermGenie]
synonym: "(+)-kotanin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900595
name: (+)-kotanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-kotanin." [GOC:di, GOC:TermGenie]
synonym: "(+)-kotanin breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900594 ! (+)-kotanin metabolic process

[Term]
id: GO:1900596
name: (+)-kotanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-kotanin." [GOC:di, GOC:TermGenie]
synonym: "(+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900594 ! (+)-kotanin metabolic process

[Term]
id: GO:1900597
name: demethylkotanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving demethylkotanin." [GOC:di, GOC:TermGenie]
synonym: "demethylkotanin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900598
name: demethylkotanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of demethylkotanin." [GOC:di, GOC:TermGenie]
synonym: "demethylkotanin breakdown" EXACT [GOC:TermGenie]
synonym: "demethylkotanin catabolism" EXACT [GOC:TermGenie]
synonym: "demethylkotanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900597 ! demethylkotanin metabolic process

[Term]
id: GO:1900599
name: demethylkotanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of demethylkotanin." [GOC:di, GOC:TermGenie]
synonym: "demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900597 ! demethylkotanin metabolic process

[Term]
id: GO:1900600
name: endocrocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving endocrocin." [GOC:di, GOC:TermGenie]
synonym: "endocrocin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1900601
name: endocrocin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of endocrocin." [GOC:di, GOC:TermGenie]
synonym: "endocrocin breakdown" EXACT [GOC:TermGenie]
synonym: "endocrocin catabolism" EXACT [GOC:TermGenie]
synonym: "endocrocin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900600 ! endocrocin metabolic process

[Term]
id: GO:1900602
name: endocrocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of endocrocin." [GOC:di, GOC:TermGenie]
synonym: "endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "endocrocin formation" EXACT [GOC:TermGenie]
synonym: "endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900600 ! endocrocin metabolic process

[Term]
id: GO:1900603
name: tensidol A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tensidol A." [GOC:di, GOC:TermGenie]
synonym: "tensidol A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:1900604
name: tensidol A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tensidol A." [GOC:di, GOC:TermGenie]
synonym: "tensidol A breakdown" EXACT [GOC:TermGenie]
synonym: "tensidol A catabolism" EXACT [GOC:TermGenie]
synonym: "tensidol A degradation" EXACT [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900603 ! tensidol A metabolic process

[Term]
id: GO:1900605
name: tensidol A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tensidol A." [GOC:di, GOC:TermGenie]
synonym: "tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "tensidol A formation" EXACT [GOC:TermGenie]
synonym: "tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900603 ! tensidol A metabolic process

[Term]
id: GO:1900606
name: tensidol B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tensidol B." [GOC:di, GOC:TermGenie]
synonym: "tensidol B metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:1900607
name: tensidol B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tensidol B." [GOC:di, GOC:TermGenie]
synonym: "tensidol B breakdown" EXACT [GOC:TermGenie]
synonym: "tensidol B catabolism" EXACT [GOC:TermGenie]
synonym: "tensidol B degradation" EXACT [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900606 ! tensidol B metabolic process

[Term]
id: GO:1900608
name: tensidol B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tensidol B." [GOC:di, GOC:TermGenie]
synonym: "tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "tensidol B formation" EXACT [GOC:TermGenie]
synonym: "tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900606 ! tensidol B metabolic process

[Term]
id: GO:1900609
name: F-9775A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving F-9775A." [GOC:di, GOC:TermGenie]
synonym: "F-9775A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:1900610
name: F-9775A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of F-9775A." [GOC:di, GOC:TermGenie]
synonym: "F-9775A breakdown" EXACT [GOC:TermGenie]
synonym: "F-9775A catabolism" EXACT [GOC:TermGenie]
synonym: "F-9775A degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1900609 ! F-9775A metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process

[Term]
id: GO:1900611
name: F-9775A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of F-9775A." [GOC:di, GOC:TermGenie]
synonym: "F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "F-9775A formation" EXACT [GOC:TermGenie]
synonym: "F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900609 ! F-9775A metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:1900612
name: F-9775B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving F-9775B." [GOC:di, GOC:TermGenie]
synonym: "F-9775B metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:1900613
name: F-9775B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of F-9775B." [GOC:di, GOC:TermGenie]
synonym: "F-9775B breakdown" EXACT [GOC:TermGenie]
synonym: "F-9775B catabolism" EXACT [GOC:TermGenie]
synonym: "F-9775B degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1900612 ! F-9775B metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process

[Term]
id: GO:1900614
name: F-9775B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of F-9775B." [GOC:di, GOC:TermGenie]
synonym: "F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "F-9775B formation" EXACT [GOC:TermGenie]
synonym: "F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900612 ! F-9775B metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:1900615
name: emericellamide A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emericellamide A." [GOC:di, GOC:TermGenie]
synonym: "emericellamide A metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900555 ! emericellamide metabolic process

[Term]
id: GO:1900616
name: emericellamide A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emericellamide A." [GOC:di, GOC:TermGenie]
synonym: "emericellamide A breakdown" EXACT [GOC:TermGenie]
synonym: "emericellamide A catabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide A degradation" EXACT [GOC:TermGenie]
is_a: GO:1900556 ! emericellamide catabolic process
is_a: GO:1900615 ! emericellamide A metabolic process

[Term]
id: GO:1900617
name: emericellamide A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emericellamide A." [GOC:di, GOC:TermGenie]
synonym: "emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900557 ! emericellamide biosynthetic process
is_a: GO:1900615 ! emericellamide A metabolic process

[Term]
id: GO:1900618
name: regulation of shoot system morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shoot morphogenesis." [GOC:TermGenie]
synonym: "regulation of shoot morphogenesis" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0010016 ! shoot system morphogenesis

[Term]
id: GO:1900619
name: acetate ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie]
synonym: "acetate ester metabolism" EXACT [GOC:TermGenie]
synonym: "acetyl ester metabolic process" EXACT [CHEBI:47622]
synonym: "acetyl ester metabolism" EXACT [CHEBI:47622]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1900620
name: acetate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie, PMID:15042596]
synonym: "acetate ester anabolism" EXACT [GOC:TermGenie]
synonym: "acetate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "acetate ester formation" EXACT [GOC:TermGenie]
synonym: "acetate ester synthesis" EXACT [GOC:TermGenie]
synonym: "acetyl ester biosynthesis" EXACT [CHEBI:47622]
synonym: "acetyl ester biosynthetic process" EXACT [CHEBI:47622]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1900619 ! acetate ester metabolic process

[Term]
id: GO:1900621
name: obsolete regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling
namespace: biological_process
def: "OBSOLETE. Calcium-mediated signaling that results in regulation of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0006357
consider: GO:0019722

[Term]
id: GO:1900622
name: obsolete positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling
namespace: biological_process
def: "OBSOLETE. Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter." [GOC:bf, GOC:BHF, GOC:dgf, GOC:TermGenie, PMID:9407035, PMID:9407036]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "calcineurin-dependent transcription activation" NARROW [PMID:9407036]
synonym: "calcineurin-dependent transcriptional induction" NARROW [PMID:9407035]
synonym: "calcineurin-mediated activation of transcription" NARROW [PMID:9407035]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0019722
consider: GO:0045944

[Term]
id: GO:1900623
name: regulation of monocyte aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
relationship: regulates GO:0070487 ! monocyte aggregation

[Term]
id: GO:1900624
name: negative regulation of monocyte aggregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "down regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "downregulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "downregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "inhibition of monocyte aggregation" NARROW [GOC:TermGenie]
synonym: "inhibition of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "negative regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
is_a: GO:1900623 ! regulation of monocyte aggregation
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
relationship: negatively_regulates GO:0070487 ! monocyte aggregation

[Term]
id: GO:1900625
name: positive regulation of monocyte aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of monocyte aggregation" NARROW [GOC:TermGenie]
synonym: "activation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "positive regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
is_a: GO:1900623 ! regulation of monocyte aggregation
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
relationship: positively_regulates GO:0070487 ! monocyte aggregation

[Term]
id: GO:1900626
name: regulation of arugosin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "regulation of arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900587 ! arugosin biosynthetic process

[Term]
id: GO:1900627
name: negative regulation of arugosin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of arugosin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900626 ! regulation of arugosin biosynthetic process
relationship: negatively_regulates GO:1900587 ! arugosin biosynthetic process

[Term]
id: GO:1900628
name: positive regulation of arugosin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of arugosin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "activation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900626 ! regulation of arugosin biosynthetic process
relationship: positively_regulates GO:1900587 ! arugosin biosynthetic process

[Term]
id: GO:1900629
name: methanophenazine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanophenazine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1900630
name: methanophenazine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methanophenazine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1900629 ! methanophenazine metabolic process

[Term]
id: GO:1900631
name: tridecane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tridecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tridecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043446 ! alkane metabolic process

[Term]
id: GO:1900632
name: tridecane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tridecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "tridecane formation" EXACT [GOC:TermGenie]
synonym: "tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043447 ! alkane biosynthetic process
is_a: GO:1900631 ! tridecane metabolic process

[Term]
id: GO:1900633
name: pentadecane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043446 ! alkane metabolic process

[Term]
id: GO:1900634
name: pentadecane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadecane anabolism" EXACT [GOC:TermGenie]
synonym: "pentadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "pentadecane formation" EXACT [GOC:TermGenie]
synonym: "pentadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043447 ! alkane biosynthetic process
is_a: GO:1900633 ! pentadecane metabolic process

[Term]
id: GO:1900635
name: heptadecane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heptadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043446 ! alkane metabolic process

[Term]
id: GO:1900636
name: heptadecane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heptadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadecane anabolism" EXACT [GOC:TermGenie]
synonym: "heptadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "heptadecane formation" EXACT [GOC:TermGenie]
synonym: "heptadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043447 ! alkane biosynthetic process
is_a: GO:1900635 ! heptadecane metabolic process

[Term]
id: GO:1900637
name: regulation of asperfuranone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:1900554 ! asperfuranone biosynthetic process

[Term]
id: GO:1900638
name: negative regulation of asperfuranone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:1900554 ! asperfuranone biosynthetic process

[Term]
id: GO:1900639
name: positive regulation of asperfuranone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "activation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of asperfuranone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "activation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:1900554 ! asperfuranone biosynthetic process

[Term]
id: GO:1900640
name: regulation of austinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:1900560 ! austinol biosynthetic process

[Term]
id: GO:1900641
name: negative regulation of austinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of austinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900640 ! regulation of austinol biosynthetic process
relationship: negatively_regulates GO:1900560 ! austinol biosynthetic process

[Term]
id: GO:1900642
name: positive regulation of austinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of austinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of austinol formation" EXACT [GOC:TermGenie]
synonym: "activation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900640 ! regulation of austinol biosynthetic process
relationship: positively_regulates GO:1900560 ! austinol biosynthetic process

[Term]
id: GO:1900643
name: obsolete regulation of chanoclavine-I biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900644
name: obsolete negative regulation of chanoclavine-I biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "down regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900645
name: obsolete positive regulation of chanoclavine-I biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "activation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900646
name: regulation of chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
relationship: regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process

[Term]
id: GO:1900647
name: negative regulation of chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process
is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process
relationship: negatively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process

[Term]
id: GO:1900648
name: positive regulation of chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process
is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process
relationship: positively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process

[Term]
id: GO:1900649
name: regulation of dehydroaustinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900563 ! dehydroaustinol biosynthetic process

[Term]
id: GO:1900650
name: negative regulation of dehydroaustinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process
relationship: negatively_regulates GO:1900563 ! dehydroaustinol biosynthetic process

[Term]
id: GO:1900651
name: positive regulation of dehydroaustinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "activation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process
relationship: positively_regulates GO:1900563 ! dehydroaustinol biosynthetic process

[Term]
id: GO:1900652
name: regulation of demethylkotanin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900599 ! demethylkotanin biosynthetic process

[Term]
id: GO:1900653
name: negative regulation of demethylkotanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process
relationship: negatively_regulates GO:1900599 ! demethylkotanin biosynthetic process

[Term]
id: GO:1900654
name: positive regulation of demethylkotanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "activation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process
relationship: positively_regulates GO:1900599 ! demethylkotanin biosynthetic process

[Term]
id: GO:1900655
name: regulation of diorcinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900572 ! diorcinol biosynthetic process

[Term]
id: GO:1900656
name: negative regulation of diorcinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900655 ! regulation of diorcinol biosynthetic process
relationship: negatively_regulates GO:1900572 ! diorcinol biosynthetic process

[Term]
id: GO:1900657
name: positive regulation of diorcinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of diorcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "activation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900655 ! regulation of diorcinol biosynthetic process
relationship: positively_regulates GO:1900572 ! diorcinol biosynthetic process

[Term]
id: GO:1900658
name: regulation of emericellamide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900557 ! emericellamide biosynthetic process

[Term]
id: GO:1900659
name: negative regulation of emericellamide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900658 ! regulation of emericellamide biosynthetic process
relationship: negatively_regulates GO:1900557 ! emericellamide biosynthetic process

[Term]
id: GO:1900660
name: positive regulation of emericellamide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900658 ! regulation of emericellamide biosynthetic process
relationship: positively_regulates GO:1900557 ! emericellamide biosynthetic process

[Term]
id: GO:1900661
name: regulation of emericellamide A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900658 ! regulation of emericellamide biosynthetic process
relationship: regulates GO:1900617 ! emericellamide A biosynthetic process

[Term]
id: GO:1900662
name: negative regulation of emericellamide A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900659 ! negative regulation of emericellamide biosynthetic process
is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process
relationship: negatively_regulates GO:1900617 ! emericellamide A biosynthetic process

[Term]
id: GO:1900663
name: positive regulation of emericellamide A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900660 ! positive regulation of emericellamide biosynthetic process
is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process
relationship: positively_regulates GO:1900617 ! emericellamide A biosynthetic process

[Term]
id: GO:1900664
name: regulation of emodin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "regulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900575 ! emodin biosynthetic process

[Term]
id: GO:1900665
name: negative regulation of emodin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of emodin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900664 ! regulation of emodin biosynthetic process
relationship: negatively_regulates GO:1900575 ! emodin biosynthetic process

[Term]
id: GO:1900666
name: positive regulation of emodin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of emodin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of emodin formation" EXACT [GOC:TermGenie]
synonym: "activation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900664 ! regulation of emodin biosynthetic process
relationship: positively_regulates GO:1900575 ! emodin biosynthetic process

[Term]
id: GO:1900667
name: regulation of endocrocin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900602 ! endocrocin biosynthetic process

[Term]
id: GO:1900668
name: negative regulation of endocrocin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900667 ! regulation of endocrocin biosynthetic process
relationship: negatively_regulates GO:1900602 ! endocrocin biosynthetic process

[Term]
id: GO:1900669
name: positive regulation of endocrocin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of endocrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "activation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900667 ! regulation of endocrocin biosynthetic process
relationship: positively_regulates GO:1900602 ! endocrocin biosynthetic process

[Term]
id: GO:1900670
name: regulation of F-9775A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
relationship: regulates GO:1900611 ! F-9775A biosynthetic process

[Term]
id: GO:1900671
name: negative regulation of F-9775A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900670 ! regulation of F-9775A biosynthetic process
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
relationship: negatively_regulates GO:1900611 ! F-9775A biosynthetic process

[Term]
id: GO:1900672
name: positive regulation of F-9775A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "activation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of F-9775A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "activation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900670 ! regulation of F-9775A biosynthetic process
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
relationship: positively_regulates GO:1900611 ! F-9775A biosynthetic process

[Term]
id: GO:1900673
name: olefin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving olefin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "olefin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0120252 ! hydrocarbon metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:1900674
name: olefin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of olefin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "olefin anabolism" EXACT [GOC:TermGenie]
synonym: "olefin biosynthesis" EXACT [GOC:TermGenie]
synonym: "olefin formation" EXACT [GOC:TermGenie]
synonym: "olefin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0120251 ! hydrocarbon biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:1900675
name: regulation of F-9775B biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
relationship: regulates GO:1900614 ! F-9775B biosynthetic process

[Term]
id: GO:1900676
name: negative regulation of F-9775B biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900675 ! regulation of F-9775B biosynthetic process
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
relationship: negatively_regulates GO:1900614 ! F-9775B biosynthetic process

[Term]
id: GO:1900677
name: positive regulation of F-9775B biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "activation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of F-9775B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "activation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900675 ! regulation of F-9775B biosynthetic process
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
relationship: positively_regulates GO:1900614 ! F-9775B biosynthetic process

[Term]
id: GO:1900678
name: regulation of ferricrocin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process
relationship: regulates GO:0031171 ! ferricrocin biosynthetic process

[Term]
id: GO:1900679
name: negative regulation of ferricrocin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "downregulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "inhibition of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process
is_a: GO:1905569 ! negative regulation of ferrichrome biosynthetic process
relationship: negatively_regulates GO:0031171 ! ferricrocin biosynthetic process

[Term]
id: GO:1900680
name: positive regulation of ferricrocin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "activation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "activation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "upregulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process
is_a: GO:1905570 ! positive regulation of ferrichrome biosynthetic process
relationship: positively_regulates GO:0031171 ! ferricrocin biosynthetic process

[Term]
id: GO:1900681
name: octadecene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octadecene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "octadecene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:1900682
name: octadecene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octadecene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "1-octadecene biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "octadecene anabolism" EXACT [GOC:TermGenie]
synonym: "octadecene biosynthesis" EXACT [GOC:TermGenie]
synonym: "octadecene formation" EXACT [GOC:TermGenie]
synonym: "octadecene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900681 ! octadecene metabolic process

[Term]
id: GO:1900683
name: regulation of fumonisin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900541 ! fumonisin biosynthetic process

[Term]
id: GO:1900684
name: negative regulation of fumonisin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900683 ! regulation of fumonisin biosynthetic process
relationship: negatively_regulates GO:1900541 ! fumonisin biosynthetic process

[Term]
id: GO:1900685
name: positive regulation of fumonisin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of fumonisin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "activation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900683 ! regulation of fumonisin biosynthetic process
relationship: positively_regulates GO:1900541 ! fumonisin biosynthetic process

[Term]
id: GO:1900686
name: regulation of gerfelin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900578 ! gerfelin biosynthetic process

[Term]
id: GO:1900687
name: negative regulation of gerfelin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900686 ! regulation of gerfelin biosynthetic process
relationship: negatively_regulates GO:1900578 ! gerfelin biosynthetic process

[Term]
id: GO:1900688
name: positive regulation of gerfelin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of gerfelin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "activation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900686 ! regulation of gerfelin biosynthetic process
relationship: positively_regulates GO:1900578 ! gerfelin biosynthetic process

[Term]
id: GO:1900689
name: regulation of gliotoxin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:2001310 ! gliotoxin biosynthetic process

[Term]
id: GO:1900690
name: negative regulation of gliotoxin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process
relationship: negatively_regulates GO:2001310 ! gliotoxin biosynthetic process

[Term]
id: GO:1900691
name: positive regulation of gliotoxin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of gliotoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "activation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process
relationship: positively_regulates GO:2001310 ! gliotoxin biosynthetic process

[Term]
id: GO:1900692
name: regulation of (+)-kotanin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900596 ! (+)-kotanin biosynthetic process

[Term]
id: GO:1900693
name: negative regulation of (+)-kotanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process
relationship: negatively_regulates GO:1900596 ! (+)-kotanin biosynthetic process

[Term]
id: GO:1900694
name: positive regulation of (+)-kotanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "activation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process
relationship: positively_regulates GO:1900596 ! (+)-kotanin biosynthetic process

[Term]
id: GO:1900695
name: regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process

[Term]
id: GO:1900696
name: negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
relationship: negatively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process

[Term]
id: GO:1900697
name: positive regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
relationship: positively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process

[Term]
id: GO:1900698
name: regulation of o-orsellinic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900584 ! o-orsellinic acid biosynthetic process

[Term]
id: GO:1900699
name: negative regulation of o-orsellinic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process
relationship: negatively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process

[Term]
id: GO:1900700
name: positive regulation of o-orsellinic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "activation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "activation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process
relationship: positively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process

[Term]
id: GO:1900701
name: regulation of orcinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of orcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0046197 ! orcinol biosynthetic process

[Term]
id: GO:1900702
name: negative regulation of orcinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of orcinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900701 ! regulation of orcinol biosynthetic process
relationship: negatively_regulates GO:0046197 ! orcinol biosynthetic process

[Term]
id: GO:1900703
name: positive regulation of orcinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of orcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "activation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900701 ! regulation of orcinol biosynthetic process
relationship: positively_regulates GO:0046197 ! orcinol biosynthetic process

[Term]
id: GO:1900704
name: regulation of siderophore biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "regulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:1900705
name: negative regulation of siderophore biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "downregulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore formation" EXACT [GOC:TermGenie]
synonym: "inhibition of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
relationship: negatively_regulates GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:1900706
name: positive regulation of siderophore biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "activation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of siderophore biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "activation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "activation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "activation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "upregulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
relationship: positively_regulates GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:1900707
name: regulation of tensidol A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900605 ! tensidol A biosynthetic process

[Term]
id: GO:1900708
name: negative regulation of tensidol A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900707 ! regulation of tensidol A biosynthetic process
relationship: negatively_regulates GO:1900605 ! tensidol A biosynthetic process

[Term]
id: GO:1900709
name: positive regulation of tensidol A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tensidol A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "activation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900707 ! regulation of tensidol A biosynthetic process
relationship: positively_regulates GO:1900605 ! tensidol A biosynthetic process

[Term]
id: GO:1900710
name: regulation of tensidol B biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900608 ! tensidol B biosynthetic process

[Term]
id: GO:1900711
name: negative regulation of tensidol B biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900710 ! regulation of tensidol B biosynthetic process
relationship: negatively_regulates GO:1900608 ! tensidol B biosynthetic process

[Term]
id: GO:1900712
name: positive regulation of tensidol B biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tensidol B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "activation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900710 ! regulation of tensidol B biosynthetic process
relationship: positively_regulates GO:1900608 ! tensidol B biosynthetic process

[Term]
id: GO:1900713
name: regulation of violaceol I biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900590 ! violaceol I biosynthetic process

[Term]
id: GO:1900714
name: negative regulation of violaceol I biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900713 ! regulation of violaceol I biosynthetic process
relationship: negatively_regulates GO:1900590 ! violaceol I biosynthetic process

[Term]
id: GO:1900715
name: positive regulation of violaceol I biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "activation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of violaceol I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "activation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900713 ! regulation of violaceol I biosynthetic process
relationship: positively_regulates GO:1900590 ! violaceol I biosynthetic process

[Term]
id: GO:1900716
name: regulation of violaceol II biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900593 ! violaceol II biosynthetic process

[Term]
id: GO:1900717
name: negative regulation of violaceol II biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900716 ! regulation of violaceol II biosynthetic process
relationship: negatively_regulates GO:1900593 ! violaceol II biosynthetic process

[Term]
id: GO:1900718
name: positive regulation of violaceol II biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "activation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of violaceol II biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "activation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900716 ! regulation of violaceol II biosynthetic process
relationship: positively_regulates GO:1900593 ! violaceol II biosynthetic process

[Term]
id: GO:1900719
name: regulation of uterine smooth muscle relaxation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie]
synonym: "regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
is_a: GO:1901080 ! regulation of relaxation of smooth muscle
relationship: regulates GO:0044558 ! uterine smooth muscle relaxation

[Term]
id: GO:1900720
name: negative regulation of uterine smooth muscle relaxation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie]
synonym: "down regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "down regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "down-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "downregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "inhibition of uterine smooth muscle relaxation" NARROW [GOC:TermGenie]
synonym: "negative regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation
is_a: GO:1901081 ! negative regulation of relaxation of smooth muscle
relationship: negatively_regulates GO:0044558 ! uterine smooth muscle relaxation

[Term]
id: GO:1900721
name: positive regulation of uterine smooth muscle relaxation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie]
synonym: "activation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "activation of uterine smooth muscle relaxation" NARROW [GOC:TermGenie]
synonym: "positive regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "up regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "up regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "up-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "upregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation
is_a: GO:1901082 ! positive regulation of relaxation of smooth muscle
relationship: positively_regulates GO:0044558 ! uterine smooth muscle relaxation

[Term]
id: GO:1900722
name: regulation of protein adenylylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein adenylylation." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein AMPylation" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0018117 ! protein adenylylation

[Term]
id: GO:1900723
name: negative regulation of protein adenylylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein adenylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein adenylylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein AMPylation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1900722 ! regulation of protein adenylylation
relationship: negatively_regulates GO:0018117 ! protein adenylylation

[Term]
id: GO:1900724
name: positive regulation of protein adenylylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein adenylylation." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "activation of protein adenylylation" NARROW [GOC:TermGenie]
synonym: "activation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "activation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein AMPylation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1900722 ! regulation of protein adenylylation
relationship: positively_regulates GO:0018117 ! protein adenylylation

[Term]
id: GO:1900725
name: osmoregulated periplasmic glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf]
synonym: "osmoregulated periplasmic glucan metabolism" EXACT [GOC:TermGenie]
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:1900726
name: osmoregulated periplasmic glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf]
synonym: "osmoregulated periplasmic glucan breakdown" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan catabolism" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan degradation" EXACT [GOC:TermGenie]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process

[Term]
id: GO:1900727
name: osmoregulated periplasmic glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf]
synonym: "osmoregulated periplasmic glucan anabolism" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan biosynthesis" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan formation" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process

[Term]
id: GO:1900728
name: cardiac neural crest cell delamination involved in outflow tract morphogenesis
namespace: biological_process
def: "Any cardiac neural crest cell delamination that is involved in outflow tract morphogenesis." [GOC:hjd, GOC:TermGenie, PMID:18539270]
is_a: GO:0036036 ! cardiac neural crest cell delamination
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:1900729
name: regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995]
synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor" RELATED [PMID:17157995]
synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of opioid receptor-mediated adenylate cyclase inhibition" RELATED []
is_a: GO:2000474 ! regulation of opioid receptor signaling pathway
relationship: regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway

[Term]
id: GO:1900730
name: negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995]
synonym: "down regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of opioid receptor-mediated adenylate cyclase inhibition" RELATED []
synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
is_a: GO:2000475 ! negative regulation of opioid receptor signaling pathway
relationship: negatively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway

[Term]
id: GO:1900731
name: positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995]
synonym: "activation of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of opioid receptor-mediated adenylate cyclase inhibition" RELATED []
synonym: "up regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
is_a: GO:2000476 ! positive regulation of opioid receptor signaling pathway
relationship: positively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway

[Term]
id: GO:1900732
name: regulation of polyketide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "regulation of polyketide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0030639 ! polyketide biosynthetic process

[Term]
id: GO:1900733
name: negative regulation of polyketide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of polyketide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
relationship: negatively_regulates GO:0030639 ! polyketide biosynthetic process

[Term]
id: GO:1900734
name: positive regulation of polyketide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of polyketide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "activation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
relationship: positively_regulates GO:0030639 ! polyketide biosynthetic process

[Term]
id: GO:1900735
name: positive regulation of flocculation
namespace: biological_process
alt_id: GO:1900479
def: "Any process that activates or increases the frequency, rate or extent of flocculation." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252]
synonym: "activation of flocculation" NARROW [GOC:TermGenie]
synonym: "activation of flocculation via cell wall protein-carbohydrate interaction" NARROW [GOC:TermGenie]
synonym: "positive regulation of flocculation via cell wall protein-carbohydrate interaction" RELATED []
synonym: "up regulation of flocculation" EXACT [GOC:TermGenie]
synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of flocculation" EXACT [GOC:TermGenie]
synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie]
synonym: "upregulation of flocculation" EXACT [GOC:TermGenie]
synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0060256 ! regulation of flocculation
relationship: positively_regulates GO:0000128 ! flocculation

[Term]
id: GO:1900736
name: regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT []
synonym: "regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway

[Term]
id: GO:1900737
name: negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "down regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "down regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "down-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "downregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "inhibition of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "negative regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT []
synonym: "negative regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:1900736 ! regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
relationship: negatively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway

[Term]
id: GO:1900738
name: positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "activation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "activation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "positive regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT []
synonym: "positive regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "up regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "up-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "upregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:1900736 ! regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
relationship: positively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway

[Term]
id: GO:1900739
name: obsolete regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:1903747

[Term]
id: GO:1900740
name: obsolete positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "activation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:1903749

[Term]
id: GO:1900741
name: regulation of filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
relationship: regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH

[Term]
id: GO:1900742
name: negative regulation of filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH
relationship: negatively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH

[Term]
id: GO:1900743
name: positive regulation of filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH
relationship: positively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH

[Term]
id: GO:1900744
name: regulation of p38MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie]
synonym: "regulation of osmosensory signaling MAPK cascade" NARROW []
synonym: "regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
is_a: GO:0043408 ! regulation of MAPK cascade
relationship: regulates GO:0038066 ! p38MAPK cascade

[Term]
id: GO:1900745
name: positive regulation of p38MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie]
synonym: "activation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "activation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "activation of p38MAPK cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of osmosensory signaling MAPK cascade" NARROW []
synonym: "positive regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of p38MAPK cascade" EXACT [GOC:TermGenie]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:1900744 ! regulation of p38MAPK cascade
relationship: positively_regulates GO:0038066 ! p38MAPK cascade

[Term]
id: GO:1900746
name: regulation of vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie]
synonym: "regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus
relationship: regulates GO:0038084 ! vascular endothelial growth factor signaling pathway

[Term]
id: GO:1900747
name: negative regulation of vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie]
synonym: "down regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway
is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus
relationship: negatively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway

[Term]
id: GO:1900748
name: positive regulation of vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie]
synonym: "activation of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "activation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "activation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway
relationship: positively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway

[Term]
id: GO:1900749
name: (R)-carnitine transport
namespace: biological_process
def: "The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798]
synonym: "(-)-Carnitine transport" RELATED [GOC:TermGenie]
synonym: "(-)-L-Carnitine transport" RELATED [GOC:TermGenie]
synonym: "(3R)-3-hydroxy-4-(trimethylammonio)butanoate transport" EXACT [GOC:TermGenie]
synonym: "C7H15NO3 transport" RELATED [GOC:TermGenie]
synonym: "Carnicor transport" RELATED [GOC:TermGenie]
synonym: "Carnitene transport" RELATED [GOC:TermGenie]
synonym: "Carnitine transport" RELATED [GOC:TermGenie]
synonym: "Carnitor transport" RELATED [GOC:TermGenie]
synonym: "L-Carnitine transport" EXACT [GOC:TermGenie]
synonym: "Levocarnitine transport" RELATED [GOC:TermGenie]
synonym: "Vitamin BT transport" RELATED [GOC:TermGenie]
is_a: GO:0015879 ! carnitine transport

[Term]
id: GO:1900750
name: oligopeptide binding
namespace: molecular_function
def: "Binding to an oligopeptide." [GOC:TermGenie, PMID:21854595]
synonym: "Oligopeptid binding" RELATED [GOC:TermGenie]
synonym: "oligopeptides binding" EXACT [GOC:TermGenie]
synonym: "oligopeptido binding" RELATED [GOC:TermGenie]
is_a: GO:0033218 ! amide binding

[Term]
id: GO:1900751
name: 4-(trimethylammonio)butanoate transport
namespace: biological_process
def: "The directed movement of a 4-(trimethylammonio)butanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798]
synonym: "4-(N-trimethylamino)butyrate transport" EXACT [GOC:TermGenie]
synonym: "4-butyrobetaine transport" EXACT [GOC:TermGenie]
synonym: "Actinine transport" RELATED [GOC:TermGenie]
synonym: "butyrobetaine transport" RELATED [GOC:TermGenie]
synonym: "C7H15NO2 transport" RELATED [GOC:TermGenie]
synonym: "deoxycarnitine transport" RELATED [GOC:TermGenie]
synonym: "gamma-Butyrobetain transport" EXACT [GOC:TermGenie]
synonym: "gamma-butyrobetaine transport" EXACT [GOC:TermGenie]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015838 ! amino-acid betaine transport

[Term]
id: GO:1900752
name: malonic acid transport
namespace: biological_process
def: "The directed movement of a malonic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9128730, PMID:9573154]
synonym: "C3H4O4 transport" RELATED [GOC:TermGenie]
synonym: "H2malo transport" RELATED [GOC:TermGenie]
synonym: "HOOC-CH2-COOH transport" RELATED [GOC:TermGenie]
synonym: "propanedioic acid transport" EXACT [GOC:TermGenie]
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:1900753
name: doxorubicin transport
namespace: biological_process
def: "The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:12057006, PMID:15090538, PMID:19063901, PMID:19651502, PMID:9651400]
synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" EXACT [GOC:TermGenie]
synonym: "(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" RELATED [GOC:TermGenie]
synonym: "(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione transport" RELATED [GOC:TermGenie]
synonym: "14-hydroxydaunomycin transport" RELATED [GOC:TermGenie]
synonym: "14-hydroxydaunorubicine transport" RELATED [GOC:TermGenie]
synonym: "Adriamycin transport" RELATED [GOC:TermGenie]
synonym: "doxorubicine transport" RELATED [GOC:TermGenie]
synonym: "doxorubicinum transport" RELATED [GOC:TermGenie]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:1900754
name: 4-hydroxyphenylacetate transport
namespace: biological_process
def: "The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9315705]
synonym: "(4-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie]
synonym: "(p-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie]
synonym: "2-(4-hydroxyphenyl)ethanoate transport" EXACT [GOC:TermGenie]
synonym: "4-hydroxybenzeneacetate transport" EXACT [GOC:TermGenie]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:1900756
name: protein processing in phagocytic vesicle
namespace: biological_process
def: "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie]
synonym: "peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0016485 ! protein processing

[Term]
id: GO:1900757
name: regulation of D-amino-acid oxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of new yellow enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1900758
name: obsolete negative regulation of D-amino-acid oxidase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "down regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "downregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of D-amino-acid oxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "inhibition of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of new yellow enzyme" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900759
name: obsolete positive regulation of D-amino-acid oxidase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of D-amino-acid oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "activation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "activation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "up regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "upregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of new yellow enzyme" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900760
name: negative regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterigmatocystin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
relationship: negatively_regulates GO:0045461 ! sterigmatocystin biosynthetic process

[Term]
id: GO:1900761
name: averantin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving averantin." [GOC:di, GOC:TermGenie]
synonym: "averantin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1900762
name: averantin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of averantin." [GOC:di, GOC:TermGenie]
synonym: "averantin breakdown" EXACT [GOC:TermGenie]
synonym: "averantin catabolism" EXACT [GOC:TermGenie]
synonym: "averantin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1900761 ! averantin metabolic process

[Term]
id: GO:1900763
name: averantin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of averantin." [GOC:di, GOC:TermGenie]
synonym: "averantin anabolism" EXACT [GOC:TermGenie]
synonym: "averantin biosynthesis" EXACT [GOC:TermGenie]
synonym: "averantin formation" EXACT [GOC:TermGenie]
synonym: "averantin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900761 ! averantin metabolic process

[Term]
id: GO:1900764
name: emericellin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emericellin." [GOC:di, GOC:TermGenie]
synonym: "emericellin metabolism" EXACT [GOC:TermGenie]
synonym: "Variecoxanthone B metabolic process" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B metabolism" RELATED [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:2001305 ! xanthone-containing compound metabolic process

[Term]
id: GO:1900765
name: emericellin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emericellin." [GOC:di, GOC:TermGenie]
synonym: "emericellin breakdown" EXACT [GOC:TermGenie]
synonym: "emericellin catabolism" EXACT [GOC:TermGenie]
synonym: "emericellin degradation" EXACT [GOC:TermGenie]
synonym: "Variecoxanthone B breakdown" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B catabolic process" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B catabolism" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B degradation" RELATED [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900764 ! emericellin metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1900766
name: emericellin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emericellin." [GOC:di, GOC:TermGenie]
synonym: "emericellin anabolism" EXACT [GOC:TermGenie]
synonym: "emericellin biosynthesis" EXACT [GOC:TermGenie]
synonym: "emericellin formation" EXACT [GOC:TermGenie]
synonym: "emericellin synthesis" EXACT [GOC:TermGenie]
synonym: "Variecoxanthone B anabolism" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B formation" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B synthesis" RELATED [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900764 ! emericellin metabolic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:2001307 ! xanthone-containing compound biosynthetic process

[Term]
id: GO:1900767
name: fonsecin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fonsecin." [GOC:di, GOC:TermGenie]
synonym: "fonsecin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process

[Term]
id: GO:1900768
name: fonsecin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fonsecin." [GOC:di, GOC:TermGenie]
synonym: "fonsecin breakdown" EXACT [GOC:TermGenie]
synonym: "fonsecin catabolism" EXACT [GOC:TermGenie]
synonym: "fonsecin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1900767 ! fonsecin metabolic process
is_a: GO:1900786 ! naphtho-gamma-pyrone catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1900769
name: fonsecin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fonsecin." [GOC:di, GOC:TermGenie]
synonym: "fonsecin anabolism" EXACT [GOC:TermGenie]
synonym: "fonsecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "fonsecin formation" EXACT [GOC:TermGenie]
synonym: "fonsecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900767 ! fonsecin metabolic process
is_a: GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1900771
name: obsolete fumitremorgin B catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumitremorgin B." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "fumitremorgin B breakdown" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B catabolism" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B degradation" EXACT [GOC:TermGenie]
synonym: "Lanosulin breakdown" RELATED [GOC:TermGenie]
synonym: "Lanosulin catabolic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin catabolism" RELATED [GOC:TermGenie]
synonym: "Lanosulin degradation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900772
name: fumitremorgin B biosynthetic process
namespace: biological_process
alt_id: GO:1900770
def: "The chemical reactions and pathways resulting in the formation of the indole alkaloid fumitremorgin B." [GOC:di, GOC:TermGenie, PMID:18683158]
synonym: "fumitremorgin B anabolism" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B formation" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B metabolic process" BROAD []
synonym: "fumitremorgin B metabolism" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B synthesis" EXACT [GOC:TermGenie]
synonym: "Lanosulin anabolism" RELATED [GOC:TermGenie]
synonym: "Lanosulin biosynthesis" RELATED [GOC:TermGenie]
synonym: "Lanosulin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin formation" RELATED [GOC:TermGenie]
synonym: "Lanosulin metabolic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin metabolism" RELATED [GOC:TermGenie]
synonym: "Lanosulin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:1900774
name: obsolete fumiquinazoline catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "fumiquinazoline breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline degradation" EXACT [GOC:TermGenie]
synonym: "fumiquinazolines breakdown" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines catabolic process" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines catabolism" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines degradation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900776
name: obsolete fumiquinazoline A metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving fumiquinazoline A." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "fumiquinazoline A metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900777
name: obsolete fumiquinazoline A catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline A." [GOC:di, GOC:TermGenie]
comment: This ter was obsoleted because there is no evidence that this process exists.
synonym: "fumiquinazoline A breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900778
name: obsolete fumiquinazoline A biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fumiquinazoline A." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "fumiquinazoline A anabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A formation" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A synthesis" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1900781

[Term]
id: GO:1900780
name: obsolete fumiquinazoline C catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline C." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "fumiquinazoline C breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900781
name: fumiquinazoline C biosynthetic process
namespace: biological_process
alt_id: GO:1900773
alt_id: GO:1900775
alt_id: GO:1900779
def: "The chemical reactions and pathways resulting in the formation of the indole alkaloid fumiquinazoline C." [GOC:di, GOC:TermGenie, PMID:20225828]
synonym: "fumiquinazoline biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline biosynthetic process" BROAD []
synonym: "fumiquinazoline C anabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C formation" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C metabolic process" BROAD []
synonym: "fumiquinazoline C metabolism" BROAD [GOC:TermGenie]
synonym: "fumiquinazoline C synthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline metabolic process" BROAD []
synonym: "fumiquinazoline metabolism" BROAD [GOC:TermGenie]
synonym: "fumiquinazolines synthesis" RELATED [GOC:TermGenie]
is_a: GO:0035835 ! indole alkaloid biosynthetic process

[Term]
id: GO:1900782
name: obsolete fumiquinazoline F metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving fumiquinazoline F." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "fumiquinazoline F metabolism" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:1900781

[Term]
id: GO:1900783
name: obsolete fumiquinazoline F catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumiquinazoline F." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "fumiquinazoline F breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900784
name: obsolete fumiquinazoline F biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fumiquinazoline F." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "fumiquinazoline F anabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F formation" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F synthesis" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1900781

[Term]
id: GO:1900785
name: naphtho-gamma-pyrone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie]
synonym: "naphtho-gamma-pyrone metabolism" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones metabolic process" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones metabolism" RELATED [GOC:TermGenie]
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1900786
name: naphtho-gamma-pyrone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie]
synonym: "naphtho-gamma-pyrone breakdown" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone catabolism" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone degradation" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones breakdown" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones catabolic process" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones catabolism" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones degradation" RELATED [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process

[Term]
id: GO:1900787
name: naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie]
synonym: "naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process

[Term]
id: GO:1900788
name: pseurotin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pseurotin A." [GOC:di, GOC:TermGenie]
synonym: "pseurotin A metabolism" EXACT [GOC:TermGenie]
synonym: "Pseurotin metabolic process" RELATED [GOC:TermGenie]
synonym: "Pseurotin metabolism" RELATED [GOC:TermGenie]
is_a: GO:0072338 ! lactam metabolic process

[Term]
id: GO:1900789
name: pseurotin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pseurotin A." [GOC:di, GOC:TermGenie]
synonym: "pseurotin A breakdown" EXACT [GOC:TermGenie]
synonym: "pseurotin A catabolism" EXACT [GOC:TermGenie]
synonym: "pseurotin A degradation" EXACT [GOC:TermGenie]
synonym: "Pseurotin breakdown" RELATED [GOC:TermGenie]
synonym: "Pseurotin catabolic process" RELATED [GOC:TermGenie]
synonym: "Pseurotin catabolism" RELATED [GOC:TermGenie]
synonym: "Pseurotin degradation" RELATED [GOC:TermGenie]
is_a: GO:0072340 ! lactam catabolic process
is_a: GO:1900788 ! pseurotin A metabolic process

[Term]
id: GO:1900790
name: pseurotin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pseurotin A." [GOC:di, GOC:TermGenie]
synonym: "pseurotin A anabolism" EXACT [GOC:TermGenie]
synonym: "pseurotin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "pseurotin A formation" EXACT [GOC:TermGenie]
synonym: "pseurotin A synthesis" EXACT [GOC:TermGenie]
synonym: "Pseurotin anabolism" RELATED [GOC:TermGenie]
synonym: "Pseurotin biosynthesis" RELATED [GOC:TermGenie]
synonym: "Pseurotin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Pseurotin formation" RELATED [GOC:TermGenie]
synonym: "Pseurotin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0072339 ! lactam biosynthetic process
is_a: GO:1900788 ! pseurotin A metabolic process

[Term]
id: GO:1900791
name: shamixanthone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving shamixanthone." [GOC:di, GOC:TermGenie]
synonym: "shamixanthone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1900792
name: shamixanthone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of shamixanthone." [GOC:di, GOC:TermGenie]
synonym: "shamixanthone breakdown" EXACT [GOC:TermGenie]
synonym: "shamixanthone catabolism" EXACT [GOC:TermGenie]
synonym: "shamixanthone degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900791 ! shamixanthone metabolic process

[Term]
id: GO:1900793
name: shamixanthone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of shamixanthone." [GOC:di, GOC:TermGenie]
synonym: "shamixanthone anabolism" EXACT [GOC:TermGenie]
synonym: "shamixanthone biosynthesis" EXACT [GOC:TermGenie]
synonym: "shamixanthone formation" EXACT [GOC:TermGenie]
synonym: "shamixanthone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900791 ! shamixanthone metabolic process

[Term]
id: GO:1900795
name: obsolete terrequinone A catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of terrequinone A." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "terrequinone A breakdown" EXACT [GOC:TermGenie]
synonym: "terrequinone A catabolism" EXACT [GOC:TermGenie]
synonym: "terrequinone A degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900796
name: terrequinone A biosynthetic process
namespace: biological_process
alt_id: GO:1900794
def: "The chemical reactions and pathways resulting in the formation of terrequinone A." [GOC:di, GOC:TermGenie, PMID:17291795, PMID:17704773]
synonym: "terrequinone A anabolism" EXACT [GOC:TermGenie]
synonym: "terrequinone A biosynthesis" EXACT [GOC:TermGenie]
synonym: "terrequinone A formation" EXACT [GOC:TermGenie]
synonym: "terrequinone A metabolic process" BROAD []
synonym: "terrequinone A metabolism" BROAD [GOC:TermGenie]
synonym: "terrequinone A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:1900797
name: cordyol C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cordyol C." [GOC:di, GOC:TermGenie]
synonym: "cordyol C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900798
name: cordyol C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cordyol C." [GOC:di, GOC:TermGenie]
synonym: "cordyol C breakdown" EXACT [GOC:TermGenie]
synonym: "cordyol C catabolism" EXACT [GOC:TermGenie]
synonym: "cordyol C degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900797 ! cordyol C metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1900799
name: cordyol C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cordyol C." [GOC:di, GOC:TermGenie]
synonym: "cordyol C anabolism" EXACT [GOC:TermGenie]
synonym: "cordyol C biosynthesis" EXACT [GOC:TermGenie]
synonym: "cordyol C formation" EXACT [GOC:TermGenie]
synonym: "cordyol C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900797 ! cordyol C metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1900800
name: cspyrone B1 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cspyrone B1." [GOC:di, GOC:TermGenie]
synonym: "cspyrone B1 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:1900801
name: cspyrone B1 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cspyrone B1." [GOC:di, GOC:TermGenie]
synonym: "cspyrone B1 breakdown" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 catabolism" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 degradation" EXACT [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900800 ! cspyrone B1 metabolic process
is_a: GO:1901335 ! lactone catabolic process

[Term]
id: GO:1900802
name: cspyrone B1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cspyrone B1." [GOC:di, GOC:TermGenie]
synonym: "cspyrone B1 anabolism" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 biosynthesis" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 formation" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900800 ! cspyrone B1 metabolic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:1900804
name: obsolete brevianamide F catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of brevianamide F." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "brevianamide F breakdown" EXACT [GOC:TermGenie]
synonym: "brevianamide F catabolism" EXACT [GOC:TermGenie]
synonym: "brevianamide F degradation" EXACT [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) breakdown" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) catabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) catabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) degradation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro breakdown" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro catabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro catabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro degradation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline breakdown" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline catabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline catabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline degradation" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride breakdown" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride catabolic process" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride catabolism" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride degradation" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride breakdown" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride catabolic process" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride catabolism" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride degradation" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine breakdown" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine catabolic process" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine catabolism" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine degradation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900805
name: brevianamide F biosynthetic process
namespace: biological_process
alt_id: GO:1900803
def: "The chemical reactions and pathways resulting in the formation of brevianamide F. Brevianamide F is the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by some fungi." [GOC:di, GOC:TermGenie, PMID:16755625, PMID:17464044]
synonym: "brevianamide F anabolism" EXACT [GOC:TermGenie]
synonym: "brevianamide F biosynthesis" EXACT [GOC:TermGenie]
synonym: "brevianamide F formation" EXACT [GOC:TermGenie]
synonym: "brevianamide F metabolic process" NARROW []
synonym: "brevianamide F synthesis" EXACT [GOC:TermGenie]
synonym: "C16H17N3O2 anabolism" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 biosynthesis" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 formation" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 synthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) anabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) biosynthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) biosynthetic process" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) formation" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) synthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro anabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro biosynthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro biosynthetic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro formation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro synthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline anabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline biosynthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline biosynthetic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline formation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline synthesis" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride anabolism" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride biosynthesis" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride biosynthetic process" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride formation" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride synthesis" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride anabolism" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthesis" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthetic process" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride formation" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride synthesis" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine anabolism" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine formation" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine synthesis" RELATED [GOC:TermGenie]
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:1900806
name: obsolete ergot alkaloid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ergot alkaloid." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "ergot alkaloid breakdown" EXACT [GOC:TermGenie]
synonym: "ergot alkaloid catabolism" EXACT [GOC:TermGenie]
synonym: "ergot alkaloid degradation" EXACT [GOC:TermGenie]
synonym: "ergot alkaloids breakdown" RELATED [GOC:TermGenie]
synonym: "ergot alkaloids catabolic process" RELATED [GOC:TermGenie]
synonym: "ergot alkaloids catabolism" RELATED [GOC:TermGenie]
synonym: "ergot alkaloids degradation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900808
name: obsolete fumigaclavine C catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fumigaclavine C." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "fumigaclavine C breakdown" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C catabolism" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900809
name: fumigaclavine C biosynthetic process
namespace: biological_process
alt_id: GO:1900807
def: "The chemical reactions and pathways resulting in the formation of fumigaclavine C, a fungal ergot alkaloid." [GOC:di, GOC:TermGenie, PMID:15933009, PMID:23435153, PMID:26972831]
synonym: "fumigaclavine C anabolism" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C formation" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C metabolic process" BROAD []
synonym: "fumigaclavine C metabolism" BROAD [GOC:TermGenie]
synonym: "fumigaclavine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0035837 ! ergot alkaloid biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process

[Term]
id: GO:1900810
name: helvolic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving helvolic acid." [GOC:di, GOC:TermGenie]
synonym: "Fumigacin metabolic process" RELATED [GOC:TermGenie]
synonym: "Fumigacin metabolism" RELATED [GOC:TermGenie]
synonym: "helvolic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process
is_a: GO:1900619 ! acetate ester metabolic process

[Term]
id: GO:1900811
name: helvolic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of helvolic acid." [GOC:di, GOC:TermGenie]
synonym: "Fumigacin breakdown" RELATED [GOC:TermGenie]
synonym: "Fumigacin catabolic process" RELATED [GOC:TermGenie]
synonym: "Fumigacin catabolism" RELATED [GOC:TermGenie]
synonym: "Fumigacin degradation" RELATED [GOC:TermGenie]
synonym: "helvolic acid breakdown" EXACT [GOC:TermGenie]
synonym: "helvolic acid catabolism" EXACT [GOC:TermGenie]
synonym: "helvolic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1900810 ! helvolic acid metabolic process

[Term]
id: GO:1900812
name: helvolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of helvolic acid." [GOC:di, GOC:TermGenie]
synonym: "Fumigacin anabolism" RELATED [GOC:TermGenie]
synonym: "Fumigacin biosynthesis" RELATED [GOC:TermGenie]
synonym: "Fumigacin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Fumigacin formation" RELATED [GOC:TermGenie]
synonym: "Fumigacin synthesis" RELATED [GOC:TermGenie]
synonym: "helvolic acid anabolism" EXACT [GOC:TermGenie]
synonym: "helvolic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "helvolic acid formation" EXACT [GOC:TermGenie]
synonym: "helvolic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1900810 ! helvolic acid metabolic process

[Term]
id: GO:1900813
name: monodictyphenone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monodictyphenone." [GOC:di, GOC:TermGenie]
synonym: "monodictyphenone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:1900814
name: monodictyphenone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monodictyphenone." [GOC:di, GOC:TermGenie]
synonym: "monodictyphenone breakdown" EXACT [GOC:TermGenie]
synonym: "monodictyphenone catabolism" EXACT [GOC:TermGenie]
synonym: "monodictyphenone degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900813 ! monodictyphenone metabolic process

[Term]
id: GO:1900815
name: monodictyphenone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monodictyphenone." [GOC:di, GOC:TermGenie]
synonym: "monodictyphenone anabolism" EXACT [GOC:TermGenie]
synonym: "monodictyphenone biosynthesis" EXACT [GOC:TermGenie]
synonym: "monodictyphenone formation" EXACT [GOC:TermGenie]
synonym: "monodictyphenone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900813 ! monodictyphenone metabolic process

[Term]
id: GO:1900816
name: ochratoxin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ochratoxin A." [GOC:di, GOC:TermGenie]
synonym: "Ochratoxin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:1900817
name: ochratoxin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ochratoxin A." [GOC:di, GOC:TermGenie]
synonym: "ochratoxin A breakdown" EXACT [GOC:TermGenie]
synonym: "ochratoxin A catabolism" EXACT [GOC:TermGenie]
synonym: "ochratoxin A degradation" EXACT [GOC:TermGenie]
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900816 ! ochratoxin A metabolic process

[Term]
id: GO:1900818
name: ochratoxin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ochratoxin A." [GOC:di, GOC:TermGenie]
synonym: "Ochratoxin A anabolism" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A formation" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900816 ! ochratoxin A metabolic process

[Term]
id: GO:1900819
name: orlandin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving orlandin." [GOC:di, GOC:TermGenie]
synonym: "orlandin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:1900820
name: orlandin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of orlandin." [GOC:di, GOC:TermGenie]
synonym: "orlandin breakdown" EXACT [GOC:TermGenie]
synonym: "orlandin catabolism" EXACT [GOC:TermGenie]
synonym: "orlandin degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900819 ! orlandin metabolic process

[Term]
id: GO:1900821
name: orlandin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of orlandin." [GOC:di, GOC:TermGenie]
synonym: "orlandin anabolism" EXACT [GOC:TermGenie]
synonym: "orlandin biosynthesis" EXACT [GOC:TermGenie]
synonym: "orlandin formation" EXACT [GOC:TermGenie]
synonym: "orlandin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900819 ! orlandin metabolic process

[Term]
id: GO:1900822
name: regulation of ergot alkaloid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:0035837 ! ergot alkaloid biosynthetic process

[Term]
id: GO:1900823
name: negative regulation of ergot alkaloid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
relationship: negatively_regulates GO:0035837 ! ergot alkaloid biosynthetic process

[Term]
id: GO:1900824
name: positive regulation of ergot alkaloid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "activation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "activation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
relationship: positively_regulates GO:0035837 ! ergot alkaloid biosynthetic process

[Term]
id: GO:1900825
name: regulation of membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]
is_a: GO:0098902 ! regulation of membrane depolarization during action potential
relationship: regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential

[Term]
id: GO:1900826
name: negative regulation of membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]
synonym: "down regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during of cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1904180 ! negative regulation of membrane depolarization
relationship: negatively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential

[Term]
id: GO:1900827
name: positive regulation of membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]
synonym: "activation of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1904181 ! positive regulation of membrane depolarization
relationship: positively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential

[Term]
id: GO:1900828
name: D-tyrosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-tyrosine." [GOC:TermGenie, PMID:10766779]
synonym: "D-tyrosine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:1900829
name: D-tyrosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-tyrosine." [GOC:TermGenie, PMID:10766779]
synonym: "D-tyrosine breakdown" EXACT [GOC:TermGenie]
synonym: "D-tyrosine catabolism" EXACT [GOC:TermGenie]
synonym: "D-tyrosine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:1900828 ! D-tyrosine metabolic process

[Term]
id: GO:1900830
name: obsolete D-tyrosine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of D-tyrosine." [GOC:TermGenie, PMID:10766779]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "D-tyrosine anabolism" EXACT [GOC:TermGenie]
synonym: "D-tyrosine biosynthesis" EXACT [GOC:TermGenie]
synonym: "D-tyrosine formation" EXACT [GOC:TermGenie]
synonym: "D-tyrosine synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900831
name: D-leucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-leucine." [GOC:TermGenie, PMID:10918062]
synonym: "D-leucine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:1900832
name: D-leucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-leucine." [GOC:TermGenie, PMID:10918062]
synonym: "D-leucine breakdown" EXACT [GOC:TermGenie]
synonym: "D-leucine catabolism" EXACT [GOC:TermGenie]
synonym: "D-leucine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009083 ! branched-chain amino acid catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:1900831 ! D-leucine metabolic process

[Term]
id: GO:1900833
name: D-leucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-leucine." [GOC:TermGenie, PMID:10918062]
synonym: "D-leucine anabolism" EXACT [GOC:TermGenie]
synonym: "D-leucine biosynthesis" EXACT [GOC:TermGenie]
synonym: "D-leucine formation" EXACT [GOC:TermGenie]
synonym: "D-leucine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009082 ! branched-chain amino acid biosynthetic process
is_a: GO:0046437 ! D-amino acid biosynthetic process
is_a: GO:1900831 ! D-leucine metabolic process

[Term]
id: GO:1900834
name: regulation of emericellin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emericellin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emericellin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emericellin formation" EXACT [GOC:TermGenie]
synonym: "regulation of emericellin synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B formation" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900766 ! emericellin biosynthetic process

[Term]
id: GO:1900835
name: negative regulation of emericellin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellin biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1900184 ! negative regulation of xanthone-containing compound biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900834 ! regulation of emericellin biosynthetic process
relationship: negatively_regulates GO:1900766 ! emericellin biosynthetic process

[Term]
id: GO:1900836
name: positive regulation of emericellin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie]
is_a: GO:1900185 ! positive regulation of xanthone-containing compound biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900834 ! regulation of emericellin biosynthetic process
relationship: positively_regulates GO:1900766 ! emericellin biosynthetic process

[Term]
id: GO:1900837
name: regulation of fumigaclavine C biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of fumigaclavine C anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumigaclavine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumigaclavine C formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumigaclavine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
relationship: regulates GO:1900809 ! fumigaclavine C biosynthetic process

[Term]
id: GO:1900838
name: negative regulation of fumigaclavine C biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "inhibition of fumigaclavine C biosynthetic process" NARROW [GOC:TermGenie]
is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process
is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process
relationship: negatively_regulates GO:1900809 ! fumigaclavine C biosynthetic process

[Term]
id: GO:1900839
name: positive regulation of fumigaclavine C biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process
is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process
relationship: positively_regulates GO:1900809 ! fumigaclavine C biosynthetic process

[Term]
id: GO:1900840
name: regulation of helvolic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900812 ! helvolic acid biosynthetic process

[Term]
id: GO:1900841
name: negative regulation of helvolic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process
relationship: negatively_regulates GO:1900812 ! helvolic acid biosynthetic process

[Term]
id: GO:1900842
name: positive regulation of helvolic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process
relationship: positively_regulates GO:1900812 ! helvolic acid biosynthetic process

[Term]
id: GO:1900843
name: regulation of monodictyphenone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of monodictyphenone anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of monodictyphenone biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of monodictyphenone formation" EXACT [GOC:TermGenie]
synonym: "regulation of monodictyphenone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900815 ! monodictyphenone biosynthetic process

[Term]
id: GO:1900844
name: negative regulation of monodictyphenone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process
relationship: negatively_regulates GO:1900815 ! monodictyphenone biosynthetic process

[Term]
id: GO:1900845
name: positive regulation of monodictyphenone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "upregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process
relationship: positively_regulates GO:1900815 ! monodictyphenone biosynthetic process

[Term]
id: GO:1900846
name: regulation of naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
relationship: regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process

[Term]
id: GO:1900847
name: negative regulation of naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process
relationship: negatively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process

[Term]
id: GO:1900848
name: positive regulation of naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process
relationship: positively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process

[Term]
id: GO:1900849
name: regulation of pseurotin A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of pseurotin A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pseurotin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pseurotin A formation" EXACT [GOC:TermGenie]
synonym: "regulation of pseurotin A synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of Pseurotin anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin formation" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:1900790 ! pseurotin A biosynthetic process

[Term]
id: GO:1900850
name: negative regulation of pseurotin A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process
relationship: negatively_regulates GO:1900790 ! pseurotin A biosynthetic process

[Term]
id: GO:1900851
name: positive regulation of pseurotin A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process
relationship: positively_regulates GO:1900790 ! pseurotin A biosynthetic process

[Term]
id: GO:1900853
name: obsolete negative regulation of terrequinone A biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "down regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900854
name: positive regulation of terrequinone A biosynthetic process
namespace: biological_process
alt_id: GO:1900852
def: "Any process that activates or increases the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie, PMID:24066102]
synonym: "regulation of terrequinone A biosynthetic process" BROAD []
synonym: "up regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
relationship: positively_regulates GO:1900796 ! terrequinone A biosynthetic process

[Term]
id: GO:1900855
name: obsolete regulation of fumitremorgin B biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "regulation of fumitremorgin B anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumitremorgin B biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumitremorgin B formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumitremorgin B synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of Lanosulin anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin formation" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin synthesis" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900856
name: obsolete negative regulation of fumitremorgin B biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "down regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900857
name: obsolete positive regulation of fumitremorgin B biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "up regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900858
name: obsolete regulation of brevianamide F biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "regulation of brevianamide F anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of brevianamide F biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of brevianamide F formation" EXACT [GOC:TermGenie]
synonym: "regulation of brevianamide F synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900859
name: obsolete negative regulation of brevianamide F biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "down regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900860
name: obsolete positive regulation of brevianamide F biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie]
comment: This term was obsoleted because it represents a pathway intermediate.
synonym: "up regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900861
name: regulation of cordyol C biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
relationship: regulates GO:1900799 ! cordyol C biosynthetic process

[Term]
id: GO:1900862
name: negative regulation of cordyol C biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900861 ! regulation of cordyol C biosynthetic process
relationship: negatively_regulates GO:1900799 ! cordyol C biosynthetic process

[Term]
id: GO:1900863
name: positive regulation of cordyol C biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of cordyol C biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900861 ! regulation of cordyol C biosynthetic process
relationship: positively_regulates GO:1900799 ! cordyol C biosynthetic process

[Term]
id: GO:1900864
name: mitochondrial RNA modification
namespace: biological_process
def: "Any RNA modification that takes place in mitochondrion." [GOC:TermGenie]
synonym: "mitochondrial RNA editing" NARROW [GOC:TermGenie]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:1900865
name: chloroplast RNA modification
namespace: biological_process
def: "Any RNA modification that takes place in chloroplast." [GOC:TermGenie]
synonym: "RNA editing in chloroplast" NARROW [GOC:TermGenie]
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:1900866
name: glycolate transport
namespace: biological_process
def: "The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:1900867
name: sarcinapterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sarcinapterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:2001115 ! methanopterin-containing compound metabolic process

[Term]
id: GO:1900868
name: sarcinapterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sarcinapterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:1900867 ! sarcinapterin metabolic process
is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process

[Term]
id: GO:1900869
name: tatiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tatiopterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:1900870
name: tatiopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tatiopterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900869 ! tatiopterin metabolic process

[Term]
id: GO:1900871
name: chloroplast mRNA modification
namespace: biological_process
def: "The covalent alteration within the chloroplast of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:TermGenie, PMID:1653905]
synonym: "chloroplast mRNA editing" NARROW []
synonym: "mRNA editing in chloroplast" NARROW [GOC:TermGenie]
is_a: GO:0016556 ! mRNA modification
is_a: GO:1900865 ! chloroplast RNA modification

[Term]
id: GO:1900872
name: pentadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:1900873
name: pentadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "pentadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "pentadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "pentadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900872 ! pentadec-1-ene metabolic process

[Term]
id: GO:1900874
name: heptadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:1900875
name: heptadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900874 ! heptadec-1-ene metabolic process

[Term]
id: GO:1900876
name: nonadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:1900877
name: nonadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900876 ! nonadec-1-ene metabolic process

[Term]
id: GO:1900878
name: (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:1900879
name: (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900674 ! olefin biosynthetic process
is_a: GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process

[Term]
id: GO:1900880
name: 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:1900881
name: 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900880 ! 18-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900882
name: 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:1900883
name: 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900882 ! 17-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900884
name: regulation of tridecane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "regulation of tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900893 ! regulation of tridecane metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:1900632 ! tridecane biosynthetic process

[Term]
id: GO:1900885
name: negative regulation of tridecane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tridecane anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane formation" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900884 ! regulation of tridecane biosynthetic process
is_a: GO:1900894 ! negative regulation of tridecane metabolic process
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
relationship: negatively_regulates GO:1900632 ! tridecane biosynthetic process

[Term]
id: GO:1900886
name: positive regulation of tridecane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tridecane anabolism" NARROW [GOC:TermGenie]
synonym: "activation of tridecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of tridecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tridecane formation" NARROW [GOC:TermGenie]
synonym: "activation of tridecane synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900884 ! regulation of tridecane biosynthetic process
is_a: GO:1900895 ! positive regulation of tridecane metabolic process
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
relationship: positively_regulates GO:1900632 ! tridecane biosynthetic process

[Term]
id: GO:1900887
name: regulation of pentadecane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of pentadecane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pentadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pentadecane formation" EXACT [GOC:TermGenie]
synonym: "regulation of pentadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900890 ! regulation of pentadecane metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:1900634 ! pentadecane biosynthetic process

[Term]
id: GO:1900888
name: negative regulation of pentadecane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "down regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of pentadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900887 ! regulation of pentadecane biosynthetic process
is_a: GO:1900891 ! negative regulation of pentadecane metabolic process
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
relationship: negatively_regulates GO:1900634 ! pentadecane biosynthetic process

[Term]
id: GO:1900889
name: positive regulation of pentadecane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of pentadecane anabolism" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane formation" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900887 ! regulation of pentadecane biosynthetic process
is_a: GO:1900892 ! positive regulation of pentadecane metabolic process
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
relationship: positively_regulates GO:1900634 ! pentadecane biosynthetic process

[Term]
id: GO:1900890
name: regulation of pentadecane metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of pentadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:1900633 ! pentadecane metabolic process

[Term]
id: GO:1900891
name: negative regulation of pentadecane metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of pentadecane metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900890 ! regulation of pentadecane metabolic process
relationship: negatively_regulates GO:1900633 ! pentadecane metabolic process

[Term]
id: GO:1900892
name: positive regulation of pentadecane metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of pentadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pentadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900890 ! regulation of pentadecane metabolic process
relationship: positively_regulates GO:1900633 ! pentadecane metabolic process

[Term]
id: GO:1900893
name: regulation of tridecane metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tridecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:1900631 ! tridecane metabolic process

[Term]
id: GO:1900894
name: negative regulation of tridecane metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of tridecane metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of tridecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900893 ! regulation of tridecane metabolic process
relationship: negatively_regulates GO:1900631 ! tridecane metabolic process

[Term]
id: GO:1900895
name: positive regulation of tridecane metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tridecane metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tridecane metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900893 ! regulation of tridecane metabolic process
relationship: positively_regulates GO:1900631 ! tridecane metabolic process

[Term]
id: GO:1900896
name: regulation of heptadecane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of heptadecane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of heptadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of heptadecane formation" EXACT [GOC:TermGenie]
synonym: "regulation of heptadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900899 ! regulation of heptadecane metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: regulates GO:1900636 ! heptadecane biosynthetic process

[Term]
id: GO:1900897
name: negative regulation of heptadecane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "down regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of heptadecane anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane formation" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900896 ! regulation of heptadecane biosynthetic process
is_a: GO:1900900 ! negative regulation of heptadecane metabolic process
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
relationship: negatively_regulates GO:1900636 ! heptadecane biosynthetic process

[Term]
id: GO:1900898
name: positive regulation of heptadecane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of heptadecane anabolism" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane formation" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900896 ! regulation of heptadecane biosynthetic process
is_a: GO:1900901 ! positive regulation of heptadecane metabolic process
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
relationship: positively_regulates GO:1900636 ! heptadecane biosynthetic process

[Term]
id: GO:1900899
name: regulation of heptadecane metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of heptadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:1900635 ! heptadecane metabolic process

[Term]
id: GO:1900900
name: negative regulation of heptadecane metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of heptadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900899 ! regulation of heptadecane metabolic process
relationship: negatively_regulates GO:1900635 ! heptadecane metabolic process

[Term]
id: GO:1900901
name: positive regulation of heptadecane metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of heptadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of heptadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900899 ! regulation of heptadecane metabolic process
relationship: positively_regulates GO:1900635 ! heptadecane metabolic process

[Term]
id: GO:1900902
name: regulation of hexadecanal biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of hexadecanal anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hexadecanal biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hexadecanal formation" EXACT [GOC:TermGenie]
synonym: "regulation of hexadecanal synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of palmitaldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of palmitaldehyde biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:1900905 ! regulation of hexadecanal metabolic process
relationship: regulates GO:0006634 ! hexadecanal biosynthetic process

[Term]
id: GO:1900903
name: negative regulation of hexadecanal biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "down regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of hexadecanal anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal formation" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of palmitaldehyde biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process
is_a: GO:1900906 ! negative regulation of hexadecanal metabolic process
relationship: negatively_regulates GO:0006634 ! hexadecanal biosynthetic process

[Term]
id: GO:1900904
name: positive regulation of hexadecanal biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of hexadecanal anabolism" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal formation" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal synthesis" NARROW [GOC:TermGenie]
synonym: "activation of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process
is_a: GO:1900907 ! positive regulation of hexadecanal metabolic process
relationship: positively_regulates GO:0006634 ! hexadecanal biosynthetic process

[Term]
id: GO:1900905
name: regulation of hexadecanal metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of hexadecanal metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0046458 ! hexadecanal metabolic process

[Term]
id: GO:1900906
name: negative regulation of hexadecanal metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of hexadecanal metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900905 ! regulation of hexadecanal metabolic process
relationship: negatively_regulates GO:0046458 ! hexadecanal metabolic process

[Term]
id: GO:1900907
name: positive regulation of hexadecanal metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of hexadecanal metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900905 ! regulation of hexadecanal metabolic process
relationship: positively_regulates GO:0046458 ! hexadecanal metabolic process

[Term]
id: GO:1900908
name: regulation of olefin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of olefin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:1900673 ! olefin metabolic process

[Term]
id: GO:1900909
name: negative regulation of olefin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of olefin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: negatively_regulates GO:1900673 ! olefin metabolic process

[Term]
id: GO:1900910
name: positive regulation of olefin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of olefin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of olefin metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of olefin metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: positively_regulates GO:1900673 ! olefin metabolic process

[Term]
id: GO:1900911
name: regulation of olefin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of olefin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of olefin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of olefin formation" EXACT [GOC:TermGenie]
synonym: "regulation of olefin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: regulates GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:1900912
name: negative regulation of olefin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "down regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of olefin anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin formation" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
relationship: negatively_regulates GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:1900913
name: positive regulation of olefin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of olefin anabolism" NARROW [GOC:TermGenie]
synonym: "activation of olefin biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of olefin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of olefin formation" NARROW [GOC:TermGenie]
synonym: "activation of olefin synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
relationship: positively_regulates GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:1900914
name: regulation of octadecene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 1-octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene formation" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900917 ! regulation of octadecene metabolic process
relationship: regulates GO:1900682 ! octadecene biosynthetic process

[Term]
id: GO:1900915
name: negative regulation of octadecene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of 1-octadecene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene formation" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900914 ! regulation of octadecene biosynthetic process
is_a: GO:1900918 ! negative regulation of octadecene metabolic process
relationship: negatively_regulates GO:1900682 ! octadecene biosynthetic process

[Term]
id: GO:1900916
name: positive regulation of octadecene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "activation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of octadecene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "activation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900914 ! regulation of octadecene biosynthetic process
is_a: GO:1900919 ! positive regulation of octadecene metabolic process
relationship: positively_regulates GO:1900682 ! octadecene biosynthetic process

[Term]
id: GO:1900917
name: regulation of octadecene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of octadecene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: regulates GO:1900681 ! octadecene metabolic process

[Term]
id: GO:1900918
name: negative regulation of octadecene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of octadecene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of octadecene metabolism" RELATED [GOC:TermGenie]
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900917 ! regulation of octadecene metabolic process
relationship: negatively_regulates GO:1900681 ! octadecene metabolic process

[Term]
id: GO:1900919
name: positive regulation of octadecene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of octadecene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of octadecene metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of octadecene metabolism" RELATED [GOC:TermGenie]
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900917 ! regulation of octadecene metabolic process
relationship: positively_regulates GO:1900681 ! octadecene metabolic process

[Term]
id: GO:1900923
name: regulation of glycine import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie]
synonym: "regulation of glycine import" BROAD []
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:1903804 ! glycine import across plasma membrane

[Term]
id: GO:1900924
name: negative regulation of glycine import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie]
synonym: "down regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "downregulation of glycine import" EXACT [GOC:TermGenie]
synonym: "inhibition of glycine import" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycine import" BROAD []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import across plasma membrane
relationship: negatively_regulates GO:1903804 ! glycine import across plasma membrane

[Term]
id: GO:1900925
name: positive regulation of glycine import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie]
synonym: "activation of glycine import" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycine import" BROAD []
synonym: "up regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "upregulation of glycine import" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import across plasma membrane
relationship: positively_regulates GO:1903804 ! glycine import across plasma membrane

[Term]
id: GO:1900926
name: regulation of L-threonine import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie]
synonym: "regulation of L-threonine import" BROAD []
synonym: "regulation of L-threonine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:1903807 ! L-threonine import across plasma membrane

[Term]
id: GO:1900927
name: negative regulation of L-threonine import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie]
synonym: "down regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-threonine import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-threonine uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-threonine uptake" RELATED [GOC:TermGenie]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane
relationship: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane

[Term]
id: GO:1900928
name: positive regulation of L-threonine import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie]
synonym: "activation of L-threonine import" NARROW [GOC:TermGenie]
synonym: "activation of L-threonine uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-threonine import" BROAD []
synonym: "positive regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "up regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-threonine uptake" RELATED [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane
relationship: positively_regulates GO:1903807 ! L-threonine import across plasma membrane

[Term]
id: GO:1900929
name: regulation of L-tyrosine import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie]
synonym: "regulation of L-tyrosine import" BROAD []
synonym: "regulation of L-tyrosine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:1903808 ! L-tyrosine import across plasma membrane

[Term]
id: GO:1900930
name: negative regulation of L-tyrosine import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie]
synonym: "down regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-tyrosine import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "negative regulation of L-tyrosine import" BROAD []
synonym: "negative regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane
relationship: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane

[Term]
id: GO:1900931
name: positive regulation of L-tyrosine import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie]
synonym: "activation of L-tyrosine import" NARROW [GOC:TermGenie]
synonym: "activation of L-tyrosine uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-tyrosine import" BROAD []
synonym: "positive regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "up regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane
relationship: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane

[Term]
id: GO:1900932
name: regulation of nonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: regulates GO:1900876 ! nonadec-1-ene metabolic process

[Term]
id: GO:1900933
name: negative regulation of nonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900876 ! nonadec-1-ene metabolic process

[Term]
id: GO:1900934
name: positive regulation of nonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process
relationship: positively_regulates GO:1900876 ! nonadec-1-ene metabolic process

[Term]
id: GO:1900935
name: regulation of nonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process
relationship: regulates GO:1900877 ! nonadec-1-ene biosynthetic process

[Term]
id: GO:1900936
name: negative regulation of nonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900933 ! negative regulation of nonadec-1-ene metabolic process
is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process
relationship: negatively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process

[Term]
id: GO:1900937
name: positive regulation of nonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "activation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "activation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900934 ! positive regulation of nonadec-1-ene metabolic process
is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process
relationship: positively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process

[Term]
id: GO:1900938
name: regulation of (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process

[Term]
id: GO:1900939
name: negative regulation of (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process
relationship: negatively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process

[Term]
id: GO:1900940
name: positive regulation of (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process
relationship: positively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process

[Term]
id: GO:1900941
name: regulation of (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process
relationship: regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process

[Term]
id: GO:1900942
name: negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900939 ! negative regulation of (Z)-nonadeca-1,14-diene metabolic process
is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process
relationship: negatively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process

[Term]
id: GO:1900943
name: positive regulation of (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900940 ! positive regulation of (Z)-nonadeca-1,14-diene metabolic process
is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process
relationship: positively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process

[Term]
id: GO:1900944
name: regulation of isoprene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of isoprene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: regulates GO:0043611 ! isoprene metabolic process

[Term]
id: GO:1900945
name: negative regulation of isoprene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of isoprene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of isoprene metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoprene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900944 ! regulation of isoprene metabolic process
relationship: negatively_regulates GO:0043611 ! isoprene metabolic process

[Term]
id: GO:1900946
name: positive regulation of isoprene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene metabolism" NARROW [GOC:TermGenie]
synonym: "activation of isoprene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of isoprene metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of isoprene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900944 ! regulation of isoprene metabolic process
relationship: positively_regulates GO:0043611 ! isoprene metabolic process

[Term]
id: GO:1900947
name: regulation of isoprene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900944 ! regulation of isoprene metabolic process
relationship: regulates GO:0043612 ! isoprene biosynthetic process

[Term]
id: GO:1900948
name: negative regulation of isoprene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of isoprene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900945 ! negative regulation of isoprene metabolic process
is_a: GO:1900947 ! regulation of isoprene biosynthetic process
relationship: negatively_regulates GO:0043612 ! isoprene biosynthetic process

[Term]
id: GO:1900949
name: positive regulation of isoprene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of isoprene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900946 ! positive regulation of isoprene metabolic process
is_a: GO:1900947 ! regulation of isoprene biosynthetic process
relationship: positively_regulates GO:0043612 ! isoprene biosynthetic process

[Term]
id: GO:1900950
name: regulation of 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process
relationship: regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process

[Term]
id: GO:1900951
name: negative regulation of 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process
is_a: GO:1900954 ! negative regulation of 18-methylnonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process

[Term]
id: GO:1900952
name: positive regulation of 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process
is_a: GO:1900955 ! positive regulation of 18-methylnonadec-1-ene metabolic process
relationship: positively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process

[Term]
id: GO:1900953
name: regulation of 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900954
name: negative regulation of 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900955
name: positive regulation of 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process
relationship: positively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900956
name: regulation of 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process
relationship: regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process

[Term]
id: GO:1900957
name: negative regulation of 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process
is_a: GO:1900960 ! negative regulation of 17-methylnonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process

[Term]
id: GO:1900958
name: positive regulation of 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process
is_a: GO:1900961 ! positive regulation of 17-methylnonadec-1-ene metabolic process
relationship: positively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process

[Term]
id: GO:1900959
name: regulation of 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900908 ! regulation of olefin metabolic process
relationship: regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900960
name: negative regulation of 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900961
name: positive regulation of 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process
relationship: positively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process

[Term]
id: GO:1900962
name: regulation of methanophenazine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:1900965 ! regulation of methanophenazine metabolic process
relationship: regulates GO:1900630 ! methanophenazine biosynthetic process

[Term]
id: GO:1900963
name: negative regulation of methanophenazine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process
is_a: GO:1900966 ! negative regulation of methanophenazine metabolic process
relationship: negatively_regulates GO:1900630 ! methanophenazine biosynthetic process

[Term]
id: GO:1900964
name: positive regulation of methanophenazine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of methanophenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "activation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process
is_a: GO:1900967 ! positive regulation of methanophenazine metabolic process
relationship: positively_regulates GO:1900630 ! methanophenazine biosynthetic process

[Term]
id: GO:1900965
name: regulation of methanophenazine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:1900629 ! methanophenazine metabolic process

[Term]
id: GO:1900966
name: negative regulation of methanophenazine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900965 ! regulation of methanophenazine metabolic process
relationship: negatively_regulates GO:1900629 ! methanophenazine metabolic process

[Term]
id: GO:1900967
name: positive regulation of methanophenazine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanophenazine metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900965 ! regulation of methanophenazine metabolic process
relationship: positively_regulates GO:1900629 ! methanophenazine metabolic process

[Term]
id: GO:1900968
name: regulation of sarcinapterin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:1900867 ! sarcinapterin metabolic process

[Term]
id: GO:1900969
name: negative regulation of sarcinapterin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045863 ! negative regulation of pteridine metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900968 ! regulation of sarcinapterin metabolic process
relationship: negatively_regulates GO:1900867 ! sarcinapterin metabolic process

[Term]
id: GO:1900970
name: positive regulation of sarcinapterin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of sarcinapterin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045864 ! positive regulation of pteridine metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900968 ! regulation of sarcinapterin metabolic process
relationship: positively_regulates GO:1900867 ! sarcinapterin metabolic process

[Term]
id: GO:1900971
name: regulation of sarcinapterin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:1900968 ! regulation of sarcinapterin metabolic process
relationship: regulates GO:1900868 ! sarcinapterin biosynthetic process

[Term]
id: GO:1900972
name: negative regulation of sarcinapterin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900969 ! negative regulation of sarcinapterin metabolic process
is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process
relationship: negatively_regulates GO:1900868 ! sarcinapterin biosynthetic process

[Term]
id: GO:1900973
name: positive regulation of sarcinapterin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "activation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900970 ! positive regulation of sarcinapterin metabolic process
is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process
relationship: positively_regulates GO:1900868 ! sarcinapterin biosynthetic process

[Term]
id: GO:1900974
name: regulation of tatiopterin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:1900977 ! regulation of tatiopterin metabolic process
relationship: regulates GO:1900870 ! tatiopterin biosynthetic process

[Term]
id: GO:1900975
name: negative regulation of tatiopterin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process
is_a: GO:1900978 ! negative regulation of tatiopterin metabolic process
relationship: negatively_regulates GO:1900870 ! tatiopterin biosynthetic process

[Term]
id: GO:1900976
name: positive regulation of tatiopterin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tatiopterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "activation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process
is_a: GO:1900979 ! positive regulation of tatiopterin metabolic process
relationship: positively_regulates GO:1900870 ! tatiopterin biosynthetic process

[Term]
id: GO:1900977
name: regulation of tatiopterin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051174 ! regulation of phosphorus metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:1900869 ! tatiopterin metabolic process

[Term]
id: GO:1900978
name: negative regulation of tatiopterin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900977 ! regulation of tatiopterin metabolic process
relationship: negatively_regulates GO:1900869 ! tatiopterin metabolic process

[Term]
id: GO:1900979
name: positive regulation of tatiopterin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tatiopterin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900977 ! regulation of tatiopterin metabolic process
relationship: positively_regulates GO:1900869 ! tatiopterin metabolic process

[Term]
id: GO:1900980
name: regulation of phenazine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0002047 ! phenazine biosynthetic process

[Term]
id: GO:1900981
name: negative regulation of phenazine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of phenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900980 ! regulation of phenazine biosynthetic process
relationship: negatively_regulates GO:0002047 ! phenazine biosynthetic process

[Term]
id: GO:1900982
name: positive regulation of phenazine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of phenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900980 ! regulation of phenazine biosynthetic process
relationship: positively_regulates GO:0002047 ! phenazine biosynthetic process

[Term]
id: GO:1900983
name: vindoline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vindoline." [GOC:TermGenie, GOC:yaf, PMID:23864440]
synonym: "vindoline metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process
is_a: GO:1900619 ! acetate ester metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:1900984
name: obsolete vindoline catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "vindoline breakdown" EXACT [GOC:TermGenie]
synonym: "vindoline catabolism" EXACT [GOC:TermGenie]
synonym: "vindoline degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900985
name: vindoline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vindoline." [GOC:TermGenie, GOC:yaf, PMID:12228585]
synonym: "vindoline anabolism" EXACT [GOC:TermGenie]
synonym: "vindoline biosynthesis" EXACT [GOC:TermGenie]
synonym: "vindoline formation" EXACT [GOC:TermGenie]
synonym: "vindoline synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-5292
is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1900983 ! vindoline metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:1900987
name: obsolete ajmaline catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ajmaline." [GOC:TermGenie, GOC:yaf]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "ajmaline breakdown" EXACT [GOC:TermGenie]
synonym: "ajmaline catabolism" EXACT [GOC:TermGenie]
synonym: "ajmaline degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900988
name: ajmaline biosynthetic process
namespace: biological_process
alt_id: GO:1900986
def: "The chemical reactions and pathways resulting in the formation of ajmaline." [GOC:TermGenie, GOC:yaf]
synonym: "ajmaline anabolism" EXACT [GOC:TermGenie]
synonym: "ajmaline biosynthesis" EXACT [GOC:TermGenie]
synonym: "ajmaline formation" EXACT [GOC:TermGenie]
synonym: "ajmaline metabolic process" BROAD []
synonym: "ajmaline metabolism" BROAD [GOC:TermGenie]
synonym: "ajmaline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:1900990
name: obsolete scopolamine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of scopolamine." [GOC:TermGenie, GOC:yaf]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "scopolamine breakdown" EXACT [GOC:TermGenie]
synonym: "scopolamine catabolism" EXACT [GOC:TermGenie]
synonym: "scopolamine degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900991
name: scopolamine biosynthetic process
namespace: biological_process
alt_id: GO:1900989
def: "The chemical reactions and pathways resulting in the formation of scopolamine." [GOC:TermGenie, GOC:yaf, PMID:16720272, PMID:18251710, PMID:32879484]
synonym: "scopolamine anabolism" EXACT [GOC:TermGenie]
synonym: "scopolamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "scopolamine formation" EXACT [GOC:TermGenie]
synonym: "scopolamine metabolic process" BROAD []
synonym: "scopolamine metabolism" BROAD [GOC:TermGenie]
synonym: "scopolamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1900992
name: obsolete (-)-secologanin metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "(-)-secologanin metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900993
name: obsolete (-)-secologanin catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "(-)-secologanin breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1900994
name: (-)-secologanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-secologanin." [GOC:TermGenie, GOC:yaf, PMID:24104568]
synonym: "(-)-secologanin anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin formation" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:1900995
name: ubiquinone-6 binding
namespace: molecular_function
def: "Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [GOC:al, GOC:TermGenie]
is_a: GO:0048039 ! ubiquinone binding

[Term]
id: GO:1900996
name: benzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272]
synonym: "benzene breakdown" EXACT [GOC:TermGenie]
synonym: "benzene catabolism" EXACT [GOC:TermGenie]
synonym: "benzene degradation" EXACT [GOC:TermGenie]
is_a: GO:0018910 ! benzene metabolic process
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:1900997
name: benzene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272]
synonym: "benzene anabolism" EXACT [GOC:TermGenie]
synonym: "benzene biosynthesis" EXACT [GOC:TermGenie]
synonym: "benzene formation" EXACT [GOC:TermGenie]
synonym: "benzene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018910 ! benzene metabolic process
is_a: GO:0120251 ! hydrocarbon biosynthetic process

[Term]
id: GO:1900998
name: nitrobenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923]
synonym: "nitrobenzene breakdown" EXACT [GOC:TermGenie]
synonym: "nitrobenzene catabolism" EXACT [GOC:TermGenie]
synonym: "nitrobenzene degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:0018916 ! nitrobenzene metabolic process

[Term]
id: GO:1900999
name: nitrobenzene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923]
synonym: "nitrobenzene anabolism" EXACT [GOC:TermGenie]
synonym: "nitrobenzene biosynthesis" EXACT [GOC:TermGenie]
synonym: "nitrobenzene formation" EXACT [GOC:TermGenie]
synonym: "nitrobenzene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0018916 ! nitrobenzene metabolic process

[Term]
id: GO:1901000
name: regulation of response to salt stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139]
synonym: "regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "regulation of salinity response" EXACT [GOC:TermGenie]
is_a: GO:0047484 ! regulation of response to osmotic stress
relationship: regulates GO:0009651 ! response to salt stress

[Term]
id: GO:1901001
name: negative regulation of response to salt stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139]
synonym: "down regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "down regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "down regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "downregulation of salinity response" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "inhibition of response to salt stress" NARROW [GOC:TermGenie]
synonym: "inhibition of salinity response" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of salinity response" EXACT [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901000 ! regulation of response to salt stress
relationship: negatively_regulates GO:0009651 ! response to salt stress

[Term]
id: GO:1901002
name: positive regulation of response to salt stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139]
synonym: "activation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "activation of response to salt stress" NARROW [GOC:TermGenie]
synonym: "activation of salinity response" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "up regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "upregulation of salinity response" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901000 ! regulation of response to salt stress
relationship: positively_regulates GO:0009651 ! response to salt stress

[Term]
id: GO:1901003
name: negative regulation of fermentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fermentation." [GOC:TermGenie]
synonym: "down regulation of fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of fermentation" EXACT [GOC:TermGenie]
synonym: "inhibition of fermentation" NARROW [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0043465 ! regulation of fermentation
relationship: negatively_regulates GO:0006113 ! fermentation

[Term]
id: GO:1901004
name: ubiquinone-6 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [GOC:al, GOC:TermGenie, PMID:1409592]
synonym: "coenzyme Q6 metabolic process" EXACT [CHEBI:52971]
synonym: "coenzyme Q6 metabolism" EXACT [CHEBI:52971]
synonym: "ubiquinone-6 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006743 ! ubiquinone metabolic process

[Term]
id: GO:1901005
name: ubiquinone-6 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone-6." [GOC:TermGenie]
synonym: "ubiquinone-6 breakdown" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 catabolism" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 degradation" EXACT [GOC:TermGenie]
is_a: GO:0032322 ! ubiquinone catabolic process
is_a: GO:1901004 ! ubiquinone-6 metabolic process

[Term]
id: GO:1901006
name: ubiquinone-6 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone-6." [GOC:TermGenie]
synonym: "ubiquinone-6 anabolism" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 biosynthesis" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 formation" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006744 ! ubiquinone biosynthetic process
is_a: GO:1901004 ! ubiquinone-6 metabolic process

[Term]
id: GO:1901007
name: obsolete (S)-scoulerine metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "(S)-scoulerine metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901008
name: obsolete (S)-scoulerine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of (S)-scoulerine." [GOC:TermGenie, GOC:yaf]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "(S)-scoulerine breakdown" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine catabolism" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901009
name: (S)-scoulerine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (S)-scoulerine." [GOC:TermGenie, GOC:yaf, PMID:15672841]
synonym: "(S)-scoulerine anabolism" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine biosynthesis" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine formation" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process

[Term]
id: GO:1901010
name: obsolete (S)-reticuline metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "(S)-reticuline metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901011
name: obsolete (S)-reticuline catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of (S)-reticuline." [GOC:TermGenie, GOC:yaf]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "(S)-reticuline breakdown" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline catabolism" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901012
name: (S)-reticuline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (S)-reticuline." [GOC:TermGenie, GOC:yaf, PMID:22725256]
synonym: "(S)-reticuline anabolism" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline biosynthesis" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline formation" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:1901014
name: obsolete 3alpha(S)-strictosidine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "3alpha(S)-strictosidine breakdown" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine catabolism" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901015
name: 3alpha(S)-strictosidine biosynthetic process
namespace: biological_process
alt_id: GO:1901013
def: "The chemical reactions and pathways resulting in the formation of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf]
synonym: "3alpha(S)-strictosidine anabolism" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine formation" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine metabolic process" BROAD []
synonym: "3alpha(S)-strictosidine metabolism" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:1901016
name: regulation of potassium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of potassium transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport

[Term]
id: GO:1901017
name: negative regulation of potassium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "down regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of potassium transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport

[Term]
id: GO:1901018
name: positive regulation of potassium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
synonym: "activation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport

[Term]
id: GO:1901019
name: regulation of calcium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport

[Term]
id: GO:1901020
name: negative regulation of calcium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport

[Term]
id: GO:1901021
name: positive regulation of calcium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport

[Term]
id: GO:1901022
name: 4-hydroxyphenylacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf]
synonym: "4-hydroxyphenylacetate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:1901023
name: 4-hydroxyphenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, PMID:8550403]
synonym: "4-hydroxyphenylacetate breakdown" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate catabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process

[Term]
id: GO:1901024
name: 4-hydroxyphenylacetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf]
synonym: "4-hydroxyphenylacetate anabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate biosynthesis" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate formation" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process

[Term]
id: GO:1901025
name: ripoptosome assembly involved in extrinsic apoptotic signaling pathway
namespace: biological_process
def: "The aggregation, arrangement and bonding together of ripoptosome components leading to apoptosis via the extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400]
is_a: GO:0097343 ! ripoptosome assembly
relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:1901026
name: ripoptosome assembly involved in necroptotic process
namespace: biological_process
def: "The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400]
synonym: "ripoptosome assembly involved in necroptosis" NARROW []
is_a: GO:0097343 ! ripoptosome assembly
relationship: part_of GO:0070266 ! necroptotic process

[Term]
id: GO:1901027
name: dextrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dextrin." [GOC:TermGenie]
synonym: "dextrin breakdown" EXACT [GOC:TermGenie]
synonym: "dextrin catabolism" EXACT [GOC:TermGenie]
synonym: "dextrin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009251 ! glucan catabolic process

[Term]
id: GO:1901028
name: regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "regulation of mitochondrial outer membrane permeabilization" BROAD []
synonym: "regulation of MOMP" EXACT [GOC:TermGenie]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0097345 ! mitochondrial outer membrane permeabilization

[Term]
id: GO:1901029
name: negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "down regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "down regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "down-regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "downregulation of MOMP" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie]
synonym: "inhibition of MOMP" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial outer membrane permeabilization" BROAD []
synonym: "negative regulation of MOMP" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0035795 ! negative regulation of mitochondrial membrane permeability
is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
relationship: negatively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization

[Term]
id: GO:1901030
name: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]
comment: Caspase 8 may be annotated to this term when it is shown to stimulate MOMP by cleaving the BH3-only protein BID.
synonym: "activation of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie]
synonym: "activation of MOMP" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial outer membrane permeabilization" BROAD []
synonym: "positive regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "up regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "upregulation of MOMP" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0035794 ! positive regulation of mitochondrial membrane permeability
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
relationship: positively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization

[Term]
id: GO:1901031
name: regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "regulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1902882 ! regulation of response to oxidative stress
relationship: regulates GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:1901032
name: negative regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "downregulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "inhibition of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "inhibition of response to AOS" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxygen species" NARROW [GOC:TermGenie]
synonym: "inhibition of response to ROI" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ROS" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1902883 ! negative regulation of response to oxidative stress
relationship: negatively_regulates GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:1901033
name: positive regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "activation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "activation of response to AOS" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxygen species" NARROW [GOC:TermGenie]
synonym: "activation of response to ROI" EXACT [GOC:TermGenie]
synonym: "activation of response to ROS" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "up regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "upregulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1902884 ! positive regulation of response to oxidative stress
relationship: positively_regulates GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:1901034
name: regulation of L-glutamine import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-glutamine import into cell." [GOC:TermGenie]
synonym: "regulation of L-glutamine import" BROAD []
synonym: "regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:2000485 ! regulation of glutamine transport
relationship: regulates GO:1903803 ! L-glutamine import across plasma membrane

[Term]
id: GO:1901035
name: negative regulation of L-glutamine import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine import into a cell." [GOC:TermGenie]
synonym: "down regulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamine import" BROAD [GOC:TermGenie]
synonym: "down-regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "inhibition of L-glutamine import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-glutamine import" BROAD []
synonym: "negative regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane
is_a: GO:2000486 ! negative regulation of glutamine transport
relationship: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane

[Term]
id: GO:1901036
name: positive regulation of L-glutamine import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-glutamine import into cell." [GOC:TermGenie]
synonym: "activation of L-glutamine import" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-glutamine import" BROAD []
synonym: "positive regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamine uptake" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane
is_a: GO:2000487 ! positive regulation of glutamine transport
relationship: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane

[Term]
id: GO:1901037
name: obsolete regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed during the M/G1 transition of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:12411492]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "global transcription regulation from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of transcription during M/G1 transition of mitotic cell cycle" BROAD []
synonym: "regulation of transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter involved in M/G1 transition of mitotic cell cycle" RELATED []
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:1901038
name: cyanidin 3-O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside." [GOC:TermGenie, PMID:21899608]
synonym: "cyanidin 3-O-beta-D-glucoside metabolic process" EXACT []
synonym: "cyanidin 3-O-beta-D-glucoside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:1901039
name: regulation of peptide antigen transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie]
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0090087 ! regulation of peptide transport
relationship: regulates GO:0046968 ! peptide antigen transport

[Term]
id: GO:1901040
name: negative regulation of peptide antigen transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie, PMID:16691491]
synonym: "down regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "downregulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "inhibition of peptide antigen transport" NARROW [GOC:TermGenie]
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1901039 ! regulation of peptide antigen transport
relationship: negatively_regulates GO:0046968 ! peptide antigen transport

[Term]
id: GO:1901041
name: positive regulation of peptide antigen transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie]
synonym: "activation of peptide antigen transport" NARROW [GOC:TermGenie]
synonym: "up regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "upregulation of peptide antigen transport" EXACT [GOC:TermGenie]
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1901039 ! regulation of peptide antigen transport
relationship: positively_regulates GO:0046968 ! peptide antigen transport

[Term]
id: GO:1901043
name: obsolete protein polyubiquitination involved in cellular response to misfolded protein
namespace: biological_process
def: "OBSOLETE. Any protein polyubiquitination that is involved in cellular response to misfolded protein." [GOC:al, GOC:TermGenie, PMID:21324894]
comment: This term was made obsolete because it was added in error and a more specific term was created.
synonym: "polyubiquitin of cellular response to misfolded protein" RELATED [GOC:TermGenie]
synonym: "protein polyubiquitination involved in cellular response to misfolded protein" EXACT []
synonym: "protein polyubiquitination of cellular response to misfolded protein" EXACT [GOC:TermGenie]
synonym: "protein polyubiquitinylation of cellular response to misfolded protein" EXACT [GOC:TermGenie]
synonym: "protein polyubiquitylation of cellular response to misfolded protein" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0071630

[Term]
id: GO:1901044
name: obsolete protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any protein polyubiquitination that is involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process." [GOC:al, GOC:TermGenie, PMID:21324894]
comment: The reason for obsoletion is that this term is pre-composed.
is_obsolete: true
consider: GO:0071630

[Term]
id: GO:1901045
name: negative regulation of egg-laying behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "down regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "down regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "down-regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "down-regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "down-regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "downregulation of egg laying" BROAD [GOC:TermGenie]
synonym: "downregulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "downregulation of oviposition" EXACT [GOC:TermGenie]
synonym: "inhibition of egg laying" BROAD [GOC:TermGenie]
synonym: "inhibition of egg-laying" BROAD [GOC:TermGenie]
synonym: "inhibition of oviposition" NARROW [GOC:TermGenie]
synonym: "negative regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "negative regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "negative regulation of oviposition" EXACT []
is_a: GO:0046662 ! regulation of egg-laying behavior
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0018991 ! egg-laying behavior

[Term]
id: GO:1901046
name: positive regulation of egg-laying behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie]
synonym: "activation of egg laying" BROAD [GOC:TermGenie]
synonym: "activation of egg-laying" BROAD [GOC:TermGenie]
synonym: "activation of oviposition" NARROW [GOC:TermGenie]
synonym: "positive regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "positive regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "positive regulation of oviposition" EXACT []
synonym: "up regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "up regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "up regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "up-regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "up-regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "up-regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "upregulation of egg laying" BROAD [GOC:TermGenie]
synonym: "upregulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "upregulation of oviposition" EXACT [GOC:TermGenie]
is_a: GO:0046662 ! regulation of egg-laying behavior
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0018991 ! egg-laying behavior

[Term]
id: GO:1901047
name: obsolete insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of the insulin receptor binding to insulin that controls viability and duration in the adult phase of the life-cycle." [GOC:kmv, GOC:TermGenie, PMID:9360933]
comment: This term was obsoleted because it represents a pathway and a readout.
synonym: "daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901048
name: obsolete transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth
namespace: biological_process
def: "OBSOLETE. The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:kmv, GOC:TermGenie, PMID:9847239]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "TGF-beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:1901050
name: obsolete atropine catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atropine." [GOC:TermGenie, GOC:yaf]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "atropine breakdown" EXACT [GOC:TermGenie]
synonym: "atropine catabolism" EXACT [GOC:TermGenie]
synonym: "atropine degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901051
name: atropine biosynthetic process
namespace: biological_process
alt_id: GO:1901049
def: "The chemical reactions and pathways resulting in the formation of atropine. Atropine is the racemic mixture of hyoscyamine." [GOC:TermGenie, GOC:yaf, PMID:2879005, PMID:33572199]
synonym: "atropine anabolism" EXACT [GOC:TermGenie]
synonym: "atropine biosynthesis" EXACT [GOC:TermGenie]
synonym: "atropine formation" EXACT [GOC:TermGenie]
synonym: "atropine metabolic process" BROAD []
synonym: "atropine metabolism" BROAD [GOC:TermGenie]
synonym: "atropine synthesis" EXACT [GOC:TermGenie]
synonym: "hyoscyamine biosynthetic process" EXACT []
is_a: GO:0009710 ! tropane alkaloid biosynthetic process

[Term]
id: GO:1901052
name: sarcosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sarcosine." [GOC:TermGenie, GOC:yaf, PMID:17951379]
synonym: "sarcosine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:1901053
name: sarcosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sarcosine." [GOC:TermGenie, GOC:yaf, PMID:17951379]
synonym: "sarcosine breakdown" EXACT [GOC:TermGenie]
synonym: "sarcosine catabolism" EXACT [GOC:TermGenie]
synonym: "sarcosine degradation" EXACT [GOC:TermGenie]
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1901052 ! sarcosine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:1901054
name: sarcosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sarcosine." [GOC:TermGenie, GOC:yaf, PMID:31402327]
synonym: "sarcosine anabolism" EXACT [GOC:TermGenie]
synonym: "sarcosine biosynthesis" EXACT [GOC:TermGenie]
synonym: "sarcosine formation" EXACT [GOC:TermGenie]
synonym: "sarcosine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1901052 ! sarcosine metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:1901055
name: trimethylenediamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]
synonym: "trimethylenediamine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:1901056
name: trimethylenediamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]
synonym: "trimethylenediamine breakdown" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine catabolism" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine degradation" EXACT [GOC:TermGenie]
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:1901055 ! trimethylenediamine metabolic process

[Term]
id: GO:1901057
name: trimethylenediamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]
synonym: "trimethylenediamine anabolism" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine formation" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:1901055 ! trimethylenediamine metabolic process

[Term]
id: GO:1901058
name: p-hydroxyphenyl lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "H-lignin metabolic process" EXACT [GOC:mengo_curators]
synonym: "p-hydroxyphenyl lignin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009808 ! lignin metabolic process

[Term]
id: GO:1901059
name: p-hydroxyphenyl lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "H-lignin catabolic process" EXACT [GOC:mengo_curators]
synonym: "p-hydroxyphenyl lignin breakdown" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin catabolism" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046274 ! lignin catabolic process
is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process

[Term]
id: GO:1901060
name: p-hydroxyphenyl lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "H-lignin biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "p-hydroxyphenyl lignin anabolism" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin formation" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009809 ! lignin biosynthetic process
is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process

[Term]
id: GO:1901061
name: guaiacyl lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "G-lignin metabolic process" EXACT [GOC:mengo_curators]
synonym: "guaiacyl lignin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009808 ! lignin metabolic process

[Term]
id: GO:1901062
name: guaiacyl lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "G-lignin catabolic process" EXACT [GOC:mengo_curators]
synonym: "guaiacyl lignin breakdown" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin catabolism" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046274 ! lignin catabolic process
is_a: GO:1901061 ! guaiacyl lignin metabolic process

[Term]
id: GO:1901063
name: guaiacyl lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "G-lignin biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "guaiacyl lignin anabolism" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin formation" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009809 ! lignin biosynthetic process
is_a: GO:1901061 ! guaiacyl lignin metabolic process

[Term]
id: GO:1901064
name: syringal lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving syringal lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "S-lignin metabolic process" EXACT [GOC:mengo_curators]
synonym: "syringal lignin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009808 ! lignin metabolic process

[Term]
id: GO:1901065
name: syringal lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of syringal lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "S-lignin catabolic process" EXACT [GOC:mengo_curators]
synonym: "syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046274 ! lignin catabolic process
is_a: GO:1901064 ! syringal lignin metabolic process

[Term]
id: GO:1901066
name: syringal lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of syringal lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "S-lignin biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009809 ! lignin biosynthetic process
is_a: GO:1901064 ! syringal lignin metabolic process

[Term]
id: GO:1901067
name: ferulate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ferulate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0033494 ! ferulate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1901068
name: guanosine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanosine-containing compounds (guanosines)." [GOC:TermGenie]
synonym: "guanosine-containing compound metabolism" EXACT [GOC:bf]
synonym: "guanosines metabolic process" EXACT [CHEBI:24458]
synonym: "guanosines metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:1901069
name: guanosine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines)." [GOC:TermGenie]
synonym: "guanosine-containing compound breakdown" EXACT [GOC:bf]
synonym: "guanosine-containing compound catabolism" EXACT [GOC:bf]
synonym: "guanosine-containing compound degradation" EXACT [GOC:bf]
synonym: "guanosines breakdown" EXACT [GOC:TermGenie]
synonym: "guanosines catabolic process" EXACT [CHEBI:24458]
synonym: "guanosines catabolism" EXACT [GOC:TermGenie]
synonym: "guanosines degradation" EXACT [GOC:TermGenie]
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:1901070
name: guanosine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines)." [GOC:TermGenie]
synonym: "guanosine-containing compound anabolism" EXACT [GOC:bf]
synonym: "guanosine-containing compound biosynthesis" EXACT [GOC:bf]
synonym: "guanosine-containing compound formation" EXACT [GOC:bf]
synonym: "guanosine-containing compound synthesis" EXACT [GOC:bf]
synonym: "guanosines anabolism" EXACT [GOC:TermGenie]
synonym: "guanosines biosynthesis" EXACT [GOC:TermGenie]
synonym: "guanosines biosynthetic process" EXACT [CHEBI:24458]
synonym: "guanosines formation" EXACT [GOC:TermGenie]
synonym: "guanosines synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:1901071
name: glucosamine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound metabolism" EXACT [GOC:bf]
synonym: "glucosamines metabolic process" EXACT [CHEBI:24271]
synonym: "glucosamines metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:1901072
name: glucosamine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound breakdown" EXACT [GOC:bf]
synonym: "glucosamine-containing compound catabolism" EXACT [GOC:bf]
synonym: "glucosamine-containing compound degradation" EXACT [GOC:bf]
synonym: "glucosamines breakdown" EXACT [GOC:TermGenie]
synonym: "glucosamines catabolic process" EXACT [CHEBI:24271]
synonym: "glucosamines catabolism" EXACT [GOC:TermGenie]
synonym: "glucosamines degradation" EXACT [GOC:TermGenie]
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:1901073
name: glucosamine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound anabolism" EXACT [GOC:bf]
synonym: "glucosamine-containing compound biosynthesis" EXACT [GOC:bf]
synonym: "glucosamine-containing compound formation" EXACT [GOC:bf]
synonym: "glucosamine-containing compound synthesis" EXACT [GOC:bf]
synonym: "glucosamines anabolism" EXACT [GOC:TermGenie]
synonym: "glucosamines biosynthesis" EXACT [GOC:TermGenie]
synonym: "glucosamines biosynthetic process" EXACT [CHEBI:24271]
synonym: "glucosamines formation" EXACT [GOC:TermGenie]
synonym: "glucosamines synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:1901074
name: regulation of engulfment of apoptotic cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756]
synonym: "regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
relationship: regulates GO:0043652 ! engulfment of apoptotic cell

[Term]
id: GO:1901075
name: negative regulation of engulfment of apoptotic cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756]
synonym: "down regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "down regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "down regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "down-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "down-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "downregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "downregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "downregulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "inhibition of engulfment of apoptotic cell" NARROW [GOC:TermGenie]
synonym: "inhibition of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie]
synonym: "inhibition of engulfment of cell corpse" NARROW [GOC:TermGenie]
synonym: "negative regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "negative regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
is_a: GO:0060101 ! negative regulation of phagocytosis, engulfment
is_a: GO:1901074 ! regulation of engulfment of apoptotic cell
is_a: GO:2000426 ! negative regulation of apoptotic cell clearance
relationship: negatively_regulates GO:0043652 ! engulfment of apoptotic cell

[Term]
id: GO:1901076
name: positive regulation of engulfment of apoptotic cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756]
synonym: "activation of engulfment of apoptotic cell" NARROW [GOC:TermGenie]
synonym: "activation of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie]
synonym: "activation of engulfment of cell corpse" NARROW [GOC:TermGenie]
synonym: "positive regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "positive regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "up regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "up regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "up regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "up-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "up-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "upregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "upregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "upregulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
is_a: GO:0060100 ! positive regulation of phagocytosis, engulfment
is_a: GO:1901074 ! regulation of engulfment of apoptotic cell
is_a: GO:2000427 ! positive regulation of apoptotic cell clearance
relationship: positively_regulates GO:0043652 ! engulfment of apoptotic cell

[Term]
id: GO:1901077
name: regulation of relaxation of muscle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie]
is_a: GO:0090257 ! regulation of muscle system process
relationship: regulates GO:0090075 ! relaxation of muscle

[Term]
id: GO:1901078
name: negative regulation of relaxation of muscle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie]
synonym: "down regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "down-regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "downregulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "inhibition of relaxation of muscle" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901077 ! regulation of relaxation of muscle
relationship: negatively_regulates GO:0090075 ! relaxation of muscle

[Term]
id: GO:1901079
name: positive regulation of relaxation of muscle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie]
synonym: "activation of relaxation of muscle" NARROW [GOC:TermGenie]
synonym: "up regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "up-regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "upregulation of relaxation of muscle" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901077 ! regulation of relaxation of muscle
relationship: positively_regulates GO:0090075 ! relaxation of muscle

[Term]
id: GO:1901080
name: regulation of relaxation of smooth muscle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie]
synonym: "regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1901077 ! regulation of relaxation of muscle
relationship: regulates GO:0044557 ! relaxation of smooth muscle

[Term]
id: GO:1901081
name: negative regulation of relaxation of smooth muscle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie]
synonym: "down regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "down regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "down-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "downregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "inhibition of relaxation of smooth muscle" NARROW [GOC:TermGenie]
synonym: "inhibition of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "negative regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1901078 ! negative regulation of relaxation of muscle
is_a: GO:1901080 ! regulation of relaxation of smooth muscle
relationship: negatively_regulates GO:0044557 ! relaxation of smooth muscle

[Term]
id: GO:1901082
name: positive regulation of relaxation of smooth muscle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie]
synonym: "activation of relaxation of smooth muscle" NARROW [GOC:TermGenie]
synonym: "activation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "positive regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "up regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "up regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "up-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "upregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1901079 ! positive regulation of relaxation of muscle
is_a: GO:1901080 ! regulation of relaxation of smooth muscle
relationship: positively_regulates GO:0044557 ! relaxation of smooth muscle

[Term]
id: GO:1901083
name: obsolete pyrrolizidine alkaloid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "pyrrolizidine alkaloid metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901084
name: obsolete pyrrolizidine alkaloid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "pyrrolizidine alkaloid breakdown" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid catabolism" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901085
name: pyrrolizidine alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, PMID:30001795]
synonym: "pyrrolizidine alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid formation" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009821 ! alkaloid biosynthetic process

[Term]
id: GO:1901086
name: benzylpenicillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]
synonym: "benzylpenicillin metabolism" EXACT [GOC:TermGenie]
synonym: "penicillin G metabolism" EXACT []
is_a: GO:0042316 ! penicillin metabolic process

[Term]
id: GO:1901087
name: benzylpenicillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]
synonym: "benzylpenicillin breakdown" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin catabolism" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin degradation" EXACT [GOC:TermGenie]
synonym: "penicillin G breakdown" EXACT []
synonym: "penicillin G catabolic process" EXACT []
synonym: "penicillin G catabolism" EXACT []
synonym: "penicillin G degradation" EXACT []
is_a: GO:0042317 ! penicillin catabolic process
is_a: GO:1901086 ! benzylpenicillin metabolic process

[Term]
id: GO:1901088
name: benzylpenicillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]
synonym: "benzylpenicillin anabolism" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin formation" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin synthesis" EXACT [GOC:TermGenie]
synonym: "penicillin G anabolism" EXACT [GOC:yaf]
synonym: "penicillin G biosynthesis" EXACT [GOC:yaf]
synonym: "penicillin G formation" EXACT [GOC:yaf]
synonym: "penicillin G synthesis" EXACT [GOC:yaf]
is_a: GO:0042318 ! penicillin biosynthetic process
is_a: GO:1901086 ! benzylpenicillin metabolic process

[Term]
id: GO:1901089
name: acetate ester metabolic process involved in fermentation
namespace: biological_process
def: "Any acetate ester metabolic process that is involved in fermentation." [GOC:sgd_curators, GOC:TermGenie]
synonym: "acetate ester metabolic process during fermentation" EXACT [GOC:sgd_curators]
is_a: GO:1900619 ! acetate ester metabolic process
relationship: part_of GO:0006113 ! fermentation

[Term]
id: GO:1901090
name: regulation of protein tetramerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie]
synonym: "regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein tetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032459 ! regulation of protein oligomerization
relationship: regulates GO:0051262 ! protein tetramerization

[Term]
id: GO:1901091
name: negative regulation of protein tetramerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie]
synonym: "down regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "inhibition of protein tetramer assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramer formation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramerization" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein tetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032460 ! negative regulation of protein oligomerization
is_a: GO:1901090 ! regulation of protein tetramerization
relationship: negatively_regulates GO:0051262 ! protein tetramerization

[Term]
id: GO:1901092
name: positive regulation of protein tetramerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie]
synonym: "activation of protein tetramer assembly" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramer formation" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramerization" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramerization" EXACT [GOC:TermGenie]
is_a: GO:0032461 ! positive regulation of protein oligomerization
is_a: GO:1901090 ! regulation of protein tetramerization
relationship: positively_regulates GO:0051262 ! protein tetramerization

[Term]
id: GO:1901093
name: regulation of protein homotetramerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie]
synonym: "regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032462 ! regulation of protein homooligomerization
is_a: GO:1901090 ! regulation of protein tetramerization
relationship: regulates GO:0051289 ! protein homotetramerization

[Term]
id: GO:1901094
name: negative regulation of protein homotetramerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie]
synonym: "down regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "inhibition of protein homotetramer assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramer formation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramerization" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032463 ! negative regulation of protein homooligomerization
is_a: GO:1901091 ! negative regulation of protein tetramerization
is_a: GO:1901093 ! regulation of protein homotetramerization
relationship: negatively_regulates GO:0051289 ! protein homotetramerization

[Term]
id: GO:1901095
name: positive regulation of protein homotetramerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie]
synonym: "activation of protein homotetramer assembly" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramer formation" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramerization" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramerization" EXACT [GOC:TermGenie]
is_a: GO:0032464 ! positive regulation of protein homooligomerization
is_a: GO:1901092 ! positive regulation of protein tetramerization
is_a: GO:1901093 ! regulation of protein homotetramerization
relationship: positively_regulates GO:0051289 ! protein homotetramerization

[Term]
id: GO:1901096
name: regulation of autophagosome maturation
namespace: biological_process
alt_id: GO:1902452
def: "Any process that modulates the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]
synonym: "regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "regulation of autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "regulation of autophagosome fusion" EXACT []
synonym: "regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
relationship: regulates GO:0097352 ! autophagosome maturation

[Term]
id: GO:1901097
name: negative regulation of autophagosome maturation
namespace: biological_process
alt_id: GO:1902453
def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]
synonym: "down regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "down regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "down regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "down-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "down-regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "downregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "downregulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "negative regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "negative regulation of autophagosome fusion" EXACT []
synonym: "negative regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
is_a: GO:1901096 ! regulation of autophagosome maturation
relationship: negatively_regulates GO:0097352 ! autophagosome maturation

[Term]
id: GO:1901098
name: positive regulation of autophagosome maturation
namespace: biological_process
alt_id: GO:1902454
def: "Any process that activates or increases the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]
synonym: "activation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "activation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "activation of autophagic vacuole fusion" NARROW [GOC:TermGenie]
synonym: "activation of autophagic vacuole maturation" NARROW [GOC:TermGenie]
synonym: "activation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "activation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "positive regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "positive regulation of autophagosome fusion" EXACT []
synonym: "positive regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "up regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "up regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "up regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "up-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "up-regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "upregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "upregulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "upregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:1901096 ! regulation of autophagosome maturation
relationship: positively_regulates GO:0097352 ! autophagosome maturation

[Term]
id: GO:1901099
name: negative regulation of signal transduction in absence of ligand
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand." [GOC:TermGenie]
synonym: "down regulation of basal signaling" NARROW [GOC:TermGenie]
synonym: "down regulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "down regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
synonym: "down regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie]
synonym: "down-regulation of basal signaling" NARROW [GOC:TermGenie]
synonym: "down-regulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "down-regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie]
synonym: "downregulation of basal signaling" NARROW [GOC:TermGenie]
synonym: "downregulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "downregulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie]
synonym: "inhibition of signal transduction in absence of ligand" NARROW [GOC:TermGenie]
synonym: "negative regulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "negative regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0038034 ! signal transduction in absence of ligand

[Term]
id: GO:1901101
name: obsolete gramicidin S metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "gramicidin S metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901102
name: obsolete gramicidin S catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]
comment: This term was obsoleted because it is an unnecessary grouping class.
synonym: "gramicidin S breakdown" EXACT [GOC:TermGenie]
synonym: "gramicidin S catabolism" EXACT [GOC:TermGenie]
synonym: "gramicidin S degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901103
name: gramicidin S biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gramicidin S." [GOC:TermGenie, GOC:yaf, PMID:7534306]
synonym: "gramicidin S anabolism" EXACT [GOC:TermGenie]
synonym: "gramicidin S biosynthesis" EXACT [GOC:TermGenie]
synonym: "gramicidin S formation" EXACT [GOC:TermGenie]
synonym: "gramicidin S synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:1901104
name: tetracenomycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]
synonym: "tetracenomycin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:1901105
name: tetracenomycin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]
synonym: "tetracenomycin C breakdown" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C catabolism" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1901104 ! tetracenomycin C metabolic process

[Term]
id: GO:1901106
name: tetracenomycin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]
synonym: "tetracenomycin C anabolism" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C formation" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901104 ! tetracenomycin C metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:1901107
name: granaticin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]
synonym: "granaticin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1901108
name: granaticin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]
synonym: "granaticin breakdown" EXACT [GOC:TermGenie]
synonym: "granaticin catabolism" EXACT [GOC:TermGenie]
synonym: "granaticin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901107 ! granaticin metabolic process

[Term]
id: GO:1901109
name: granaticin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]
synonym: "granaticin anabolism" EXACT [GOC:TermGenie]
synonym: "granaticin biosynthesis" EXACT [GOC:TermGenie]
synonym: "granaticin formation" EXACT [GOC:TermGenie]
synonym: "granaticin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901107 ! granaticin metabolic process

[Term]
id: GO:1901110
name: actinorhodin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]
synonym: "actinorhodin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:1901111
name: actinorhodin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]
synonym: "actinorhodin breakdown" EXACT [GOC:TermGenie]
synonym: "actinorhodin catabolism" EXACT [GOC:TermGenie]
synonym: "actinorhodin degradation" EXACT [GOC:TermGenie]
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:1901110 ! actinorhodin metabolic process

[Term]
id: GO:1901112
name: actinorhodin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]
synonym: "actinorhodin anabolism" EXACT [GOC:TermGenie]
synonym: "actinorhodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "actinorhodin formation" EXACT [GOC:TermGenie]
synonym: "actinorhodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:1901110 ! actinorhodin metabolic process

[Term]
id: GO:1901113
name: erythromycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]
synonym: "erythromycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0033067 ! macrolide metabolic process

[Term]
id: GO:1901114
name: erythromycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]
synonym: "erythromycin breakdown" EXACT [GOC:TermGenie]
synonym: "erythromycin catabolism" EXACT [GOC:TermGenie]
synonym: "erythromycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1901113 ! erythromycin metabolic process
is_a: GO:1901335 ! lactone catabolic process

[Term]
id: GO:1901115
name: erythromycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]
synonym: "erythromycin anabolism" EXACT [GOC:TermGenie]
synonym: "erythromycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "erythromycin formation" EXACT [GOC:TermGenie]
synonym: "erythromycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033068 ! macrolide biosynthetic process
is_a: GO:1901113 ! erythromycin metabolic process

[Term]
id: GO:1901116
name: cephamycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]
synonym: "cephamycin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process

[Term]
id: GO:1901117
name: cephamycin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]
synonym: "cephamycin C breakdown" EXACT [GOC:TermGenie]
synonym: "cephamycin C catabolism" EXACT [GOC:TermGenie]
synonym: "cephamycin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901116 ! cephamycin C metabolic process

[Term]
id: GO:1901118
name: cephamycin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]
synonym: "cephamycin C anabolism" EXACT [GOC:TermGenie]
synonym: "cephamycin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "cephamycin C formation" EXACT [GOC:TermGenie]
synonym: "cephamycin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901116 ! cephamycin C metabolic process

[Term]
id: GO:1901119
name: tobramycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]
synonym: "tobramycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:1901120
name: tobramycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]
synonym: "tobramycin breakdown" EXACT [GOC:TermGenie]
synonym: "tobramycin catabolism" EXACT [GOC:TermGenie]
synonym: "tobramycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901119 ! tobramycin metabolic process

[Term]
id: GO:1901121
name: tobramycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]
synonym: "tobramycin anabolism" EXACT [GOC:TermGenie]
synonym: "tobramycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "tobramycin formation" EXACT [GOC:TermGenie]
synonym: "tobramycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901119 ! tobramycin metabolic process

[Term]
id: GO:1901122
name: bacitracin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
synonym: "bacitracin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:1901123
name: bacitracin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
synonym: "bacitracin A breakdown" EXACT [GOC:TermGenie]
synonym: "bacitracin A catabolism" EXACT [GOC:TermGenie]
synonym: "bacitracin A degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901122 ! bacitracin A metabolic process

[Term]
id: GO:1901124
name: bacitracin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
synonym: "bacitracin A anabolism" EXACT [GOC:TermGenie]
synonym: "bacitracin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "bacitracin A formation" EXACT [GOC:TermGenie]
synonym: "bacitracin A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901122 ! bacitracin A metabolic process

[Term]
id: GO:1901125
name: candicidin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]
synonym: "candicidin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901126
name: candicidin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]
synonym: "candicidin breakdown" EXACT [GOC:TermGenie]
synonym: "candicidin catabolism" EXACT [GOC:TermGenie]
synonym: "candicidin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901125 ! candicidin metabolic process

[Term]
id: GO:1901127
name: candicidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]
synonym: "candicidin anabolism" EXACT [GOC:TermGenie]
synonym: "candicidin biosynthesis" EXACT [GOC:TermGenie]
synonym: "candicidin formation" EXACT [GOC:TermGenie]
synonym: "candicidin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901125 ! candicidin metabolic process

[Term]
id: GO:1901128
name: gentamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]
synonym: "gentamycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:1901129
name: gentamycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]
synonym: "gentamycin breakdown" EXACT [GOC:TermGenie]
synonym: "gentamycin catabolism" EXACT [GOC:TermGenie]
synonym: "gentamycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901128 ! gentamycin metabolic process

[Term]
id: GO:1901130
name: gentamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]
synonym: "gentamycin anabolism" EXACT [GOC:TermGenie]
synonym: "gentamycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "gentamycin formation" EXACT [GOC:TermGenie]
synonym: "gentamycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901128 ! gentamycin metabolic process

[Term]
id: GO:1901131
name: kanamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]
synonym: "kanamycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:1901132
name: kanamycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]
synonym: "kanamycin breakdown" EXACT [GOC:TermGenie]
synonym: "kanamycin catabolism" EXACT [GOC:TermGenie]
synonym: "kanamycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901131 ! kanamycin metabolic process

[Term]
id: GO:1901133
name: kanamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]
synonym: "kanamycin anabolism" EXACT [GOC:TermGenie]
synonym: "kanamycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "kanamycin formation" EXACT [GOC:TermGenie]
synonym: "kanamycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901131 ! kanamycin metabolic process

[Term]
id: GO:1901135
name: carbohydrate derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]
subset: goslim_agr
subset: goslim_generic
subset: goslim_mouse
subset: goslim_prokaryote
synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901136
name: carbohydrate derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:1901137
name: carbohydrate derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:1901140
name: p-coumaryl alcohol transport
namespace: biological_process
def: "The directed movement of a p-coumaryl alcohol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
synonym: "4-hydroxycinnamyl alcohol transport" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:1901141
name: regulation of lignin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lignin biosynthetic process." [GOC:TermGenie]
synonym: "regulation of lignin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of lignin formation" EXACT [GOC:TermGenie]
synonym: "regulation of lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
relationship: regulates GO:0009809 ! lignin biosynthetic process

[Term]
id: GO:1901142
name: insulin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie]
synonym: "insulin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:1901143
name: insulin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie]
synonym: "insulin breakdown" EXACT [GOC:TermGenie]
synonym: "insulin catabolism" EXACT [GOC:TermGenie]
synonym: "insulin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030163 ! protein catabolic process
is_a: GO:1901142 ! insulin metabolic process

[Term]
id: GO:1901144
name: obsolete insulin biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of insulin." [GOC:TermGenie]
synonym: "insulin anabolism" EXACT [GOC:TermGenie]
synonym: "insulin biosynthesis" EXACT [GOC:TermGenie]
synonym: "insulin biosynthetic process" EXACT []
synonym: "insulin formation" EXACT [GOC:TermGenie]
synonym: "insulin synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901145
name: mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
is_a: GO:0097152 ! mesenchymal cell apoptotic process
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:1901146
name: mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis

[Term]
id: GO:1901147
name: mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis

[Term]
id: GO:1901148
name: gene expression involved in extracellular matrix organization
namespace: biological_process
def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558]
synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf]
synonym: "extracellular matrix protein production" RELATED [GOC:pg]
is_a: GO:0010467 ! gene expression
relationship: part_of GO:0030198 ! extracellular matrix organization

[Term]
id: GO:1901149
name: salicylic acid binding
namespace: molecular_function
def: "Binding to salicylic acid." [GOC:TermGenie, PMID:22699612]
synonym: "salicylic acid receptor" NARROW [PMID:22699612]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:1901150
name: vistamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]
synonym: "ribostamycin metabolic process" EXACT [GOC:yaf]
synonym: "ribostamycin metabolism" EXACT [GOC:yaf]
synonym: "vistamycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:1901151
name: vistamycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]
synonym: "ribostamycin breakdown" EXACT [GOC:yaf]
synonym: "ribostamycin catabolic process" EXACT [GOC:yaf]
synonym: "ribostamycin catabolism" EXACT [GOC:yaf]
synonym: "ribostamycin degradation" EXACT [GOC:yaf]
synonym: "vistamycin breakdown" EXACT [GOC:TermGenie]
synonym: "vistamycin catabolism" EXACT [GOC:TermGenie]
synonym: "vistamycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901150 ! vistamycin metabolic process

[Term]
id: GO:1901152
name: vistamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]
synonym: "ribostamycin anabolism" EXACT [GOC:yaf]
synonym: "ribostamycin biosynthesis" EXACT [GOC:yaf]
synonym: "ribostamycin biosynthetic process" EXACT [GOC:yaf]
synonym: "ribostamycin formation" EXACT [GOC:yaf]
synonym: "ribostamycin synthesis" EXACT [GOC:yaf]
synonym: "vistamycin anabolism" EXACT [GOC:TermGenie]
synonym: "vistamycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "vistamycin formation" EXACT [GOC:TermGenie]
synonym: "vistamycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901150 ! vistamycin metabolic process

[Term]
id: GO:1901153
name: paromomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]
synonym: "paromomycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:1901154
name: paromomycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]
synonym: "paromomycin breakdown" EXACT [GOC:TermGenie]
synonym: "paromomycin catabolism" EXACT [GOC:TermGenie]
synonym: "paromomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901153 ! paromomycin metabolic process

[Term]
id: GO:1901155
name: paromomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]
synonym: "paromomycin anabolism" EXACT [GOC:TermGenie]
synonym: "paromomycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "paromomycin formation" EXACT [GOC:TermGenie]
synonym: "paromomycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901153 ! paromomycin metabolic process

[Term]
id: GO:1901156
name: neomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]
synonym: "neomycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:1901157
name: neomycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]
synonym: "neomycin breakdown" EXACT [GOC:TermGenie]
synonym: "neomycin catabolism" EXACT [GOC:TermGenie]
synonym: "neomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901156 ! neomycin metabolic process

[Term]
id: GO:1901158
name: neomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]
synonym: "neomycin anabolism" EXACT [GOC:TermGenie]
synonym: "neomycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "neomycin formation" EXACT [GOC:TermGenie]
synonym: "neomycin synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-7016
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901156 ! neomycin metabolic process

[Term]
id: GO:1901159
name: xylulose 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate." [GOC:bf, GOC:TermGenie]
synonym: "xylulose 5-phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "xylulose 5-phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "xylulose 5-phosphate formation" EXACT [GOC:TermGenie]
synonym: "xylulose 5-phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:1901160
name: primary amino compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901161
name: primary amino compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie]
synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:1901162
name: primary amino compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "primary amino compound formation" EXACT [GOC:TermGenie]
synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:1901163
name: regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0061450 ! trophoblast cell migration

[Term]
id: GO:1901164
name: negative regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0061450 ! trophoblast cell migration

[Term]
id: GO:1901165
name: positive regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0061450 ! trophoblast cell migration

[Term]
id: GO:1901166
name: neural crest cell migration involved in autonomic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie]
is_a: GO:0001755 ! neural crest cell migration
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:1901167
name: 3-chlorocatechol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]
synonym: "3-chlorocatechol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0090345 ! organohalogen metabolic process

[Term]
id: GO:1901168
name: 3-chlorocatechol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]
synonym: "3-chlorocatechol breakdown" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol catabolism" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:1901167 ! 3-chlorocatechol metabolic process

[Term]
id: GO:1901169
name: 3-chlorocatechol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]
synonym: "3-chlorocatechol anabolism" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol formation" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:1901167 ! 3-chlorocatechol metabolic process

[Term]
id: GO:1901170
name: naphthalene catabolic process
namespace: biological_process
alt_id: GO:0018931
def: "The chemical reactions and pathways resulting in the breakdown of naphthalene." [GOC:TermGenie, GOC:yaf, PMID:11133965]
synonym: "naphthalene breakdown" EXACT [GOC:TermGenie]
synonym: "naphthalene catabolism" EXACT [GOC:TermGenie]
synonym: "naphthalene degradation" EXACT [GOC:TermGenie]
synonym: "naphthalene metabolic process" RELATED []
synonym: "naphthalene metabolism" RELATED []
xref: UM-BBD_pathwayID:naph
is_a: GO:0120253 ! hydrocarbon catabolic process

[Term]
id: GO:1901171
name: obsolete naphthalene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of naphthalene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00082]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "naphthalene anabolism" EXACT [GOC:TermGenie]
synonym: "naphthalene biosynthesis" EXACT [GOC:TermGenie]
synonym: "naphthalene formation" EXACT [GOC:TermGenie]
synonym: "naphthalene synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901172
name: phytoene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]
synonym: "phytoene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process

[Term]
id: GO:1901173
name: phytoene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]
synonym: "phytoene breakdown" EXACT [GOC:TermGenie]
synonym: "phytoene catabolism" EXACT [GOC:TermGenie]
synonym: "phytoene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901172 ! phytoene metabolic process

[Term]
id: GO:1901174
name: phytoene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]
synonym: "phytoene anabolism" EXACT [GOC:TermGenie]
synonym: "phytoene biosynthesis" EXACT [GOC:TermGenie]
synonym: "phytoene formation" EXACT [GOC:TermGenie]
synonym: "phytoene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901172 ! phytoene metabolic process

[Term]
id: GO:1901175
name: lycopene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]
synonym: "lycopene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process

[Term]
id: GO:1901176
name: lycopene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]
synonym: "lycopene breakdown" EXACT [GOC:TermGenie]
synonym: "lycopene catabolism" EXACT [GOC:TermGenie]
synonym: "lycopene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901175 ! lycopene metabolic process

[Term]
id: GO:1901177
name: lycopene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]
synonym: "lycopene anabolism" EXACT [GOC:TermGenie]
synonym: "lycopene biosynthesis" EXACT [GOC:TermGenie]
synonym: "lycopene formation" EXACT [GOC:TermGenie]
synonym: "lycopene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901175 ! lycopene metabolic process

[Term]
id: GO:1901178
name: spheroidene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]
synonym: "spheroidene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:1901179
name: spheroidene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]
synonym: "spheroidene breakdown" EXACT [GOC:TermGenie]
synonym: "spheroidene catabolism" EXACT [GOC:TermGenie]
synonym: "spheroidene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901178 ! spheroidene metabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:1901180
name: spheroidene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]
synonym: "spheroidene anabolism" EXACT [GOC:TermGenie]
synonym: "spheroidene biosynthesis" EXACT [GOC:TermGenie]
synonym: "spheroidene formation" EXACT [GOC:TermGenie]
synonym: "spheroidene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901178 ! spheroidene metabolic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:1901181
name: negative regulation of cellular response to caffeine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to caffeine." [GOC:TermGenie]
synonym: "down regulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to caffeine" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0071313 ! cellular response to caffeine

[Term]
id: GO:1901182
name: obsolete regulation of camalexin biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie]
comment: This term was obsoleted because it was an unnecessary grouping class.
synonym: "regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "regulation of camalexin synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901183
name: positive regulation of camalexin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie]
synonym: "activation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of camalexin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "activation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process
relationship: positively_regulates GO:0010120 ! camalexin biosynthetic process

[Term]
id: GO:1901184
name: regulation of ERBB signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:1901185
name: negative regulation of ERBB signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of ERBB signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1901184 ! regulation of ERBB signaling pathway
relationship: negatively_regulates GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:1901186
name: positive regulation of ERBB signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "activation of ERBB signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1901184 ! regulation of ERBB signaling pathway
relationship: positively_regulates GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:1901187
name: regulation of ephrin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048013 ! ephrin receptor signaling pathway

[Term]
id: GO:1901188
name: negative regulation of ephrin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of ephrin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway
relationship: negatively_regulates GO:0048013 ! ephrin receptor signaling pathway

[Term]
id: GO:1901189
name: positive regulation of ephrin receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "activation of ephrin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway
relationship: positively_regulates GO:0048013 ! ephrin receptor signaling pathway

[Term]
id: GO:1901190
name: regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0001677 ! formation of translation initiation ternary complex

[Term]
id: GO:1901191
name: negative regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
relationship: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex

[Term]
id: GO:1901192
name: positive regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
relationship: positively_regulates GO:0001677 ! formation of translation initiation ternary complex

[Term]
id: GO:1901193
name: regulation of formation of translation preinitiation complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie]
synonym: "regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
relationship: regulates GO:0001731 ! formation of translation preinitiation complex

[Term]
id: GO:1901194
name: negative regulation of formation of translation preinitiation complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie]
synonym: "down regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "down regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "down regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "downregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation preinitiation complex" NARROW [GOC:TermGenie]
synonym: "inhibition of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1901193 ! regulation of formation of translation preinitiation complex
is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation
relationship: negatively_regulates GO:0001731 ! formation of translation preinitiation complex

[Term]
id: GO:1901195
name: positive regulation of formation of translation preinitiation complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie]
synonym: "activation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "activation of formation of translation preinitiation complex" NARROW [GOC:TermGenie]
synonym: "activation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "positive regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "up regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "upregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1901193 ! regulation of formation of translation preinitiation complex
relationship: positively_regulates GO:0001731 ! formation of translation preinitiation complex

[Term]
id: GO:1901196
name: positive regulation of calcium-mediated signaling involved in cellular response to salt stress
namespace: biological_process
def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to salt stress." [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
relationship: part_of GO:0071472 ! cellular response to salt stress

[Term]
id: GO:1901197
name: positive regulation of calcium-mediated signaling involved in cellular response to calcium ion
namespace: biological_process
def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion." [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion" EXACT [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in response to calcium ion" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
relationship: part_of GO:0071277 ! cellular response to calcium ion

[Term]
id: GO:1901198
name: positive regulation of calcium ion transport into cytosol involved in cellular response to calcium ion
namespace: biological_process
def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to calcium ion." [GOC:TermGenie]
synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol
relationship: part_of GO:0071277 ! cellular response to calcium ion

[Term]
id: GO:1901199
name: positive regulation of calcium ion transport into cytosol involved in cellular response to salt stress
namespace: biological_process
def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie]
synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie]
is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol
relationship: part_of GO:0071472 ! cellular response to salt stress

[Term]
id: GO:1901200
name: negative regulation of calcium ion transport into cytosol involved in cellular response to salt stress
namespace: biological_process
def: "Any negative regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie]
synonym: "negative regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie]
is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol
relationship: part_of GO:0071472 ! cellular response to salt stress

[Term]
id: GO:1901201
name: regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903053 ! regulation of extracellular matrix organization
relationship: regulates GO:0085029 ! extracellular matrix assembly

[Term]
id: GO:1901202
name: negative regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie]
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
relationship: negatively_regulates GO:0085029 ! extracellular matrix assembly

[Term]
id: GO:1901203
name: positive regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
relationship: positively_regulates GO:0085029 ! extracellular matrix assembly

[Term]
id: GO:1901204
name: obsolete regulation of adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie]
comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation.
synonym: "regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901205
name: obsolete negative regulation of adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie]
comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation.
synonym: "down regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "negative regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901206
name: obsolete positive regulation of adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie]
comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation.
synonym: "activation of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "activation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "positive regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901207
name: regulation of heart looping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of cardiac looping" EXACT [GOC:TermGenie]
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0001947 ! heart looping

[Term]
id: GO:1901208
name: negative regulation of heart looping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "down regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "downregulation of heart looping" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac looping" EXACT [GOC:TermGenie]
synonym: "inhibition of heart looping" NARROW [GOC:TermGenie]
synonym: "negative regulation of cardiac looping" EXACT [GOC:TermGenie]
is_a: GO:1901207 ! regulation of heart looping
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0001947 ! heart looping

[Term]
id: GO:1901209
name: positive regulation of heart looping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "activation of heart looping" NARROW [GOC:TermGenie]
synonym: "positive regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "up regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "upregulation of heart looping" EXACT [GOC:TermGenie]
is_a: GO:1901207 ! regulation of heart looping
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0001947 ! heart looping

[Term]
id: GO:1901210
name: regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0003207 ! cardiac chamber formation

[Term]
id: GO:1901211
name: negative regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901210 ! regulation of cardiac chamber formation
relationship: negatively_regulates GO:0003207 ! cardiac chamber formation

[Term]
id: GO:1901212
name: positive regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:1901210 ! regulation of cardiac chamber formation
is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis
relationship: positively_regulates GO:0003207 ! cardiac chamber formation

[Term]
id: GO:1901213
name: obsolete regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901214
name: obsolete regulation of neuron death
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
comment: The reason for obsoletion is that this term often represents an assay, or a phenotype and not a GO process.
synonym: "regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "regulation of neuronal cell death" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901215
name: obsolete negative regulation of neuron death
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
comment: The reason for obsoletion is that this term often represents an assay, or a phenotype and not a GO process.
synonym: "down regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "inhibition of neuron cell death" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron death" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal cell death" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuronal cell death" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901216
name: obsolete positive regulation of neuron death
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
comment: The reason for obsoletion is that this term often represents an assay, or a phenotype and not a GO process.
synonym: "activation of neuron cell death" NARROW [GOC:TermGenie]
synonym: "activation of neuron death" NARROW [GOC:TermGenie]
synonym: "activation of neuronal cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "up regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "up regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "up regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal cell death" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901217
name: obsolete regulation of holin activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0098772

[Term]
id: GO:1901218
name: obsolete negative regulation of holin activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "antiholin activity" EXACT []
synonym: "down regulation of holin activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of holin activity" EXACT [GOC:TermGenie]
synonym: "downregulation of holin activity" EXACT [GOC:TermGenie]
synonym: "inhibition of holin activity" NARROW [GOC:TermGenie]
synonym: "phage antiholin" NARROW [GOC:bm]
is_obsolete: true
consider: GO:0140313
consider: GO:0140678

[Term]
id: GO:1901219
name: regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:2000826 ! regulation of heart morphogenesis
relationship: regulates GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:1901220
name: negative regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
relationship: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:1901221
name: positive regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
relationship: positively_regulates GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:1901222
name: regulation of non-canonical NF-kappaB signal transduction
namespace: biological_process
alt_id: GO:0042345
alt_id: GO:0042348
def: "Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade." [GOC:TermGenie]
synonym: "NF-kappaB import into nucleus" NARROW []
synonym: "NF-KB import into nucleus" NARROW [GOC:bf]
synonym: "regulation of NF-kappaB import into nucleus" NARROW []
synonym: "regulation of NIK/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "regulation of NIK/NF-kappaB signaling" EXACT []
synonym: "regulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "regulation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0038061 ! non-canonical NF-kappaB signal transduction

[Term]
id: GO:1901223
name: negative regulation of non-canonical NF-kappaB signal transduction
namespace: biological_process
alt_id: GO:0042347
def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade." [GOC:TermGenie]
synonym: "down regulation of NIK/NF-kappaB cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "down-regulation of NIK/NF-kappaB cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "downregulation of NIK/NF-kappaB cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of NF-kappaB import into nucleus" NARROW []
synonym: "negative regulation of NIK/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "negative regulation of NIK/NF-kappaB signaling" EXACT []
synonym: "negative regulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
is_a: GO:1901222 ! regulation of non-canonical NF-kappaB signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0038061 ! non-canonical NF-kappaB signal transduction

[Term]
id: GO:1901224
name: positive regulation of non-canonical NF-kappaB signal transduction
namespace: biological_process
alt_id: GO:0008588
alt_id: GO:0042346
def: "Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade." [GOC:TermGenie]
synonym: "activation of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie]
synonym: "activation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "activation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "activation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "activation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of NF-kappaB import into nucleus" NARROW []
synonym: "positive regulation of NIK/NF-kappaB cascade" EXACT [GOC:signaling]
synonym: "positive regulation of NIK/NF-kappaB signaling" EXACT []
synonym: "positive regulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "up regulation of NIK/NF-kappaB cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of noncanonical NF-kappaB signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "up-regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "up-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "upregulation of NIK/NF-kappaB cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of non-canonical NF-KB signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "upregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
is_a: GO:1901222 ! regulation of non-canonical NF-kappaB signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0038061 ! non-canonical NF-kappaB signal transduction

[Term]
id: GO:1901225
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0007507

[Term]
id: GO:1901226
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "activation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT []
synonym: "up regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0007507
consider: GO:0045944

[Term]
id: GO:1901227
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901228
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901229
name: obsolete regulation of non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0046328
consider: GO:2000050

[Term]
id: GO:1901230
name: obsolete negative regulation of non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "inhibition of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "negative regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" RELATED [GOC:signaling]
is_obsolete: true
consider: GO:2000051

[Term]
id: GO:1901231
name: obsolete positive regulation of non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "activation of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "positive regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling]
synonym: "up regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0046330
consider: GO:2000052

[Term]
id: GO:1901232
name: regulation of convergent extension involved in axis elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0060028 ! convergent extension involved in axis elongation

[Term]
id: GO:1901233
name: negative regulation of convergent extension involved in axis elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in axis elongation" NARROW [GOC:TermGenie]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation

[Term]
id: GO:1901234
name: positive regulation of convergent extension involved in axis elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of convergent extension involved in axis elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0060028 ! convergent extension involved in axis elongation

[Term]
id: GO:1901235
name: (R)-carnitine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of (R)-carnitine from one side of a membrane to the other." [GOC:TermGenie, PMID:16365042, PMID:20357772, PMID:20829798]
is_a: GO:0015226 ! carnitine transmembrane transporter activity

[Term]
id: GO:1901236
name: 4-(trimethylammonio)butanoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other." [GOC:TermGenie, PMID:16952940, PMID:21784948]
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity

[Term]
id: GO:1901238
name: ABC-type tungstate transporter activity
namespace: molecular_function
alt_id: GO:1901237
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out)." [GOC:TermGenie, PMID:16952940, PMID:21784948, RHEA:35027]
synonym: "ATPase-coupled tungstate transmembrane transporter activity" RELATED []
synonym: "tungstate transmembrane transporter activity" BROAD []
synonym: "tungstate transmembrane-transporting ATPase activity" RELATED []
xref: EC:7.3.2.6
xref: MetaCyc:TRANS-RXN-242B
xref: RHEA:35027
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:1901239
name: malonate(1-) transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901549
def: "Enables the transfer of malonate(1-) from one side of a membrane to the other." [GOC:TermGenie, PMID:9128730, PMID:9573154]
synonym: "malonic acid uptake transmembrane transporter activity" RELATED []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:1901241
name: 4-hydroxyphenylacetate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other." [GOC:TermGenie, PMID:9315705]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:1901242
name: ABC-type doxorubicin transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out)." [GOC:TermGenie, PMID:12057006, PMID:15090538]
synonym: "ATPase-coupled doxorubicin transmembrane transporter activity" RELATED []
synonym: "doxorubicin transmembrane-transporting ATPase activity" RELATED []
xref: TC:3.A.1.105.1
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:1901244
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter to protect the cell or organism in response to the presence of a fungus." [GOC:kmv, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0045944
consider: GO:0050832

[Term]
id: GO:1901245
name: positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization
namespace: biological_process
def: "The movement of a B cell receptor (BCR) from the plasma membrane to the inside of the cell, which results in positive regulation of toll-like receptor 9 (TLR9) signaling. For example, internalized BCR signals to recruit TLR9 from multiple small endosomes to large autophagosome-like compartments to enhance TLR9 signaling." [GOC:amm, GOC:bf, GOC:TermGenie, PMID:18513998]
synonym: "BCR-induced TLR9 recruitment" NARROW [PMID:18513998]
synonym: "positive regulation of TLR9 signaling pathway by B cell receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of TLR9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of TLR9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signalling pathway by B cell receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR endocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR receptor internalization" EXACT [GOC:TermGenie]
is_a: GO:0034165 ! positive regulation of toll-like receptor 9 signaling pathway
is_a: GO:0036300 ! B cell receptor internalization
is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization

[Term]
id: GO:1901246
name: regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0061141 ! lung ciliated cell differentiation

[Term]
id: GO:1901247
name: negative regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lung ciliated cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901246 ! regulation of lung ciliated cell differentiation
relationship: negatively_regulates GO:0061141 ! lung ciliated cell differentiation

[Term]
id: GO:1901248
name: positive regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of lung ciliated cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901246 ! regulation of lung ciliated cell differentiation
relationship: positively_regulates GO:0061141 ! lung ciliated cell differentiation

[Term]
id: GO:1901249
name: regulation of lung goblet cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0060480 ! lung goblet cell differentiation

[Term]
id: GO:1901250
name: negative regulation of lung goblet cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lung goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901249 ! regulation of lung goblet cell differentiation
relationship: negatively_regulates GO:0060480 ! lung goblet cell differentiation

[Term]
id: GO:1901251
name: positive regulation of lung goblet cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of lung goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901249 ! regulation of lung goblet cell differentiation
relationship: positively_regulates GO:0060480 ! lung goblet cell differentiation

[Term]
id: GO:1901252
name: regulation of intracellular transport of viral material
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of egress of virus within host cell." [GOC:bf, GOC:jl, GOC:TermGenie]
synonym: "regulation of egress of virus within host cell" RELATED []
synonym: "regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "regulation of viral egress" EXACT [GOC:TermGenie]
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
is_a: GO:1903900 ! regulation of viral life cycle
relationship: regulates GO:0075733 ! intracellular transport of virus

[Term]
id: GO:1901253
name: negative regulation of intracellular transport of viral material
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie]
synonym: "down regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "down-regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "downregulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of viral egress" EXACT [GOC:TermGenie]
synonym: "inhibition of egress of virus within host cell" NARROW [GOC:TermGenie]
synonym: "inhibition of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "inhibition of viral egress" EXACT [GOC:TermGenie]
synonym: "negative regulation of egress of virus within host cell" RELATED []
synonym: "negative regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral egress" EXACT [GOC:TermGenie]
is_a: GO:1901252 ! regulation of intracellular transport of viral material
is_a: GO:1903901 ! negative regulation of viral life cycle
relationship: negatively_regulates GO:0075733 ! intracellular transport of virus

[Term]
id: GO:1901254
name: positive regulation of intracellular transport of viral material
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie]
synonym: "activation of egress of virus within host cell" NARROW [GOC:TermGenie]
synonym: "activation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "activation of viral egress" EXACT [GOC:TermGenie]
synonym: "positive regulation of egress of virus within host cell" RELATED []
synonym: "positive regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "up regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "up-regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "upregulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of viral egress" EXACT [GOC:TermGenie]
is_a: GO:1901252 ! regulation of intracellular transport of viral material
is_a: GO:1903902 ! positive regulation of viral life cycle
relationship: positively_regulates GO:0075733 ! intracellular transport of virus

[Term]
id: GO:1901255
name: nucleotide-excision repair involved in interstrand cross-link repair
namespace: biological_process
def: "Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]
synonym: "NER involved in ICL repair" EXACT [GOC:TermGenie]
synonym: "NER involved in interstrand cross-link repair" EXACT [GOC:TermGenie]
synonym: "nucleotide-excision repair involved in ICL repair" EXACT [GOC:TermGenie]
is_a: GO:0006289 ! nucleotide-excision repair
relationship: part_of GO:0036297 ! interstrand cross-link repair

[Term]
id: GO:1901256
name: regulation of macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of M-CSF production" EXACT [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0036301 ! macrophage colony-stimulating factor production

[Term]
id: GO:1901257
name: negative regulation of macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "down regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "down-regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "downregulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "inhibition of M-CSF production" EXACT [GOC:TermGenie]
synonym: "inhibition of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie]
synonym: "negative regulation of M-CSF production" EXACT [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production
relationship: negatively_regulates GO:0036301 ! macrophage colony-stimulating factor production

[Term]
id: GO:1901258
name: positive regulation of macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie]
synonym: "activation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "activation of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie]
synonym: "positive regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "up regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "up regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "up-regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "upregulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production
relationship: positively_regulates GO:0036301 ! macrophage colony-stimulating factor production

[Term]
id: GO:1901259
name: chloroplast rRNA processing
namespace: biological_process
def: "Any rRNA processing that takes place in chloroplast." [GOC:TermGenie]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:1901260
name: obsolete peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification
namespace: biological_process
def: "OBSOLETE. Any peptidyl-lysine hydroxylation that is involved in bacterial-type EF-P lysine modification." [GOC:imk, GOC:TermGenie, PMID:22706199]
comment: This term was obsoleted because it represents a molecular function.
synonym: "EF-P lysine hydroxylation" RELATED [PMID:3555234]
is_obsolete: true

[Term]
id: GO:1901261
name: regulation of sorocarp spore cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie]
is_a: GO:0031156 ! regulation of sorocarp development
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0044671 ! sorocarp spore cell differentiation

[Term]
id: GO:1901262
name: negative regulation of sorocarp spore cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie]
synonym: "down regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of sorocarp spore cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation
relationship: negatively_regulates GO:0044671 ! sorocarp spore cell differentiation

[Term]
id: GO:1901263
name: positive regulation of sorocarp spore cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie]
synonym: "activation of sorocarp spore cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation
relationship: positively_regulates GO:0044671 ! sorocarp spore cell differentiation

[Term]
id: GO:1901264
name: carbohydrate derivative transport
namespace: biological_process
def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0006810 ! transport

[Term]
id: GO:1901265
name: nucleoside phosphate binding
namespace: molecular_function
def: "Binding to nucleoside phosphate." [GOC:TermGenie]
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:1901266
name: cephalosporin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]
synonym: "cephalosporin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043645 ! cephalosporin metabolic process

[Term]
id: GO:1901267
name: cephalosporin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]
synonym: "cephalosporin C breakdown" EXACT [GOC:TermGenie]
synonym: "cephalosporin C catabolism" EXACT [GOC:TermGenie]
synonym: "cephalosporin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901266 ! cephalosporin C metabolic process

[Term]
id: GO:1901268
name: cephalosporin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]
synonym: "cephalosporin C anabolism" EXACT [GOC:TermGenie]
synonym: "cephalosporin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "cephalosporin C formation" EXACT [GOC:TermGenie]
synonym: "cephalosporin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043646 ! cephalosporin biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901266 ! cephalosporin C metabolic process

[Term]
id: GO:1901269
name: lipooligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]
synonym: "lipooligosaccharide metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:1901270
name: lipooligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]
synonym: "lipooligosaccharide breakdown" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide catabolism" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide degradation" EXACT [GOC:TermGenie]
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process

[Term]
id: GO:1901271
name: lipooligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]
synonym: "lipooligosaccharide anabolism" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide biosynthesis" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide formation" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process

[Term]
id: GO:1901272
name: 2-dehydro-3-deoxy-D-gluconic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]
synonym: "2-dehydro-3-deoxy-D-gluconic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:1901273
name: 2-dehydro-3-deoxy-D-gluconic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]
synonym: "2-dehydro-3-deoxy-D-gluconic acid breakdown" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid catabolism" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process

[Term]
id: GO:1901274
name: 2-dehydro-3-deoxy-D-gluconic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]
synonym: "2-dehydro-3-deoxy-D-gluconic acid anabolism" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid formation" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process

[Term]
id: GO:1901275
name: tartrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]
synonym: "tartrate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901276
name: tartrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]
synonym: "tartrate breakdown" EXACT [GOC:TermGenie]
synonym: "tartrate catabolism" EXACT [GOC:TermGenie]
synonym: "tartrate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901275 ! tartrate metabolic process

[Term]
id: GO:1901277
name: tartrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]
synonym: "tartrate anabolism" EXACT [GOC:TermGenie]
synonym: "tartrate biosynthesis" EXACT [GOC:TermGenie]
synonym: "tartrate formation" EXACT [GOC:TermGenie]
synonym: "tartrate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901275 ! tartrate metabolic process

[Term]
id: GO:1901278
name: D-ribose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]
synonym: "D-ribose 5-phosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019693 ! ribose phosphate metabolic process

[Term]
id: GO:1901279
name: D-ribose 5-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]
synonym: "D-ribose 5-phosphate breakdown" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate catabolism" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process

[Term]
id: GO:1901280
name: D-ribose 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]
synonym: "D-ribose 5-phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate formation" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046390 ! ribose phosphate biosynthetic process
is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process

[Term]
id: GO:1901281
name: fructoselysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784]
synonym: "fructosyllysine breakdown" EXACT [GOC:TermGenie]
synonym: "fructosyllysine catabolic process" EXACT []
synonym: "fructosyllysine catabolism" EXACT [GOC:TermGenie]
synonym: "fructosyllysine degradation" EXACT [GOC:TermGenie]
is_a: GO:0030392 ! fructosamine catabolic process
is_a: GO:0030393 ! fructoselysine metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:1901282
name: fructoselysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784]
synonym: "fructosyllysine anabolism" EXACT [GOC:TermGenie]
synonym: "fructosyllysine biosynthesis" EXACT [GOC:TermGenie]
synonym: "fructosyllysine biosynthetic process" EXACT []
synonym: "fructosyllysine formation" EXACT [GOC:TermGenie]
synonym: "fructosyllysine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030391 ! fructosamine biosynthetic process
is_a: GO:0030393 ! fructoselysine metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:1901283
name: 5,6,7,8-tetrahydromethanopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]
synonym: "5,6,7,8-tetrahydromethanopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:2001117 ! tetrahydromethanopterin metabolic process

[Term]
id: GO:1901284
name: 5,6,7,8-tetrahydromethanopterin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]
synonym: "5,6,7,8-tetrahydromethanopterin breakdown" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin catabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin degradation" EXACT [GOC:TermGenie]
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process

[Term]
id: GO:1901285
name: 5,6,7,8-tetrahydromethanopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]
synonym: "5,6,7,8-tetrahydromethanopterin anabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin formation" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process
is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process

[Term]
id: GO:1901286
name: iron-sulfur-molybdenum cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]
synonym: "FeMo-co metabolic process" EXACT [GOC:yaf]
synonym: "FeMo-co metabolism" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor metabolic process" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor metabolism" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901287
name: iron-sulfur-molybdenum cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]
synonym: "FeMo-co breakdown" EXACT [GOC:yaf]
synonym: "FeMo-co catabolic process" EXACT [GOC:yaf]
synonym: "FeMo-co catabolism" EXACT [GOC:yaf]
synonym: "FeMo-co degradation" EXACT [GOC:yaf]
synonym: "iron-molybdenum breakdown" EXACT [GOC:yaf]
synonym: "iron-molybdenum catabolic process" EXACT [GOC:yaf]
synonym: "iron-molybdenum catabolism" EXACT [GOC:yaf]
synonym: "iron-molybdenum degradation" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor breakdown" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor catabolism" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process

[Term]
id: GO:1901288
name: iron-sulfur-molybdenum cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]
synonym: "FeMo-co anabolism" EXACT [GOC:yaf]
synonym: "FeMo-co biosynthesis" EXACT [GOC:yaf]
synonym: "FeMo-co biosynthetic process" EXACT [GOC:yaf]
synonym: "FeMo-co formation" EXACT [GOC:yaf]
synonym: "FeMo-co synthesis" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor anabolism" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor biosynthesis" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor biosynthetic process" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor formation" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor synthesis" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor anabolism" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor formation" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process

[Term]
id: GO:1901289
name: succinyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929]
synonym: "succinyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:1901290
name: succinyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929]
synonym: "succinyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:1901291
name: negative regulation of double-strand break repair via single-strand annealing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie]
synonym: "down-regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie]
synonym: "downregulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie]
synonym: "inhibition of double-strand break repair via single-strand annealing" NARROW [GOC:TermGenie]
is_a: GO:2000780 ! negative regulation of double-strand break repair
relationship: negatively_regulates GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:1901292
name: nucleoside phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]
synonym: "nucleoside phosphate breakdown" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate catabolism" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:1901293
name: nucleoside phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie]
synonym: "nucleoside phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate formation" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:1901294
name: obsolete negative regulation of SREBP signaling pathway by negative regulation of DNA binding
namespace: biological_process
def: "OBSOLETE. Negative regulation of DNA binding that results in negative regulation of a SREBP signaling pathway." [GOC:TermGenie, PMID:22017871]
comment: The reason for obsoletion is that this term should be represented by a GO-CAM model.
synonym: "inhibition of SREBP-dependent transcription by blocking DNA binding" EXACT [PMID:22017871]
synonym: "negative regulation of SREBP signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901295
name: obsolete regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060828
consider: GO:0060923

[Term]
id: GO:1901296
name: obsolete negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060923
consider: GO:0090090

[Term]
id: GO:1901297
name: obsolete positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT []
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
synonym: "up regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0060923
consider: GO:0090263

[Term]
id: GO:1901298
name: regulation of hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie]
is_a: GO:0043067 ! regulation of programmed cell death
relationship: regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death

[Term]
id: GO:1901299
name: negative regulation of hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death
relationship: negatively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death

[Term]
id: GO:1901300
name: positive regulation of hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie]
synonym: "activation of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death
relationship: positively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death

[Term]
id: GO:1901301
name: regulation of cargo loading into COPII-coated vesicle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle." [GOC:lb, GOC:TermGenie, PMID:15899885]
synonym: "regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:0090110 ! COPII-coated vesicle cargo loading

[Term]
id: GO:1901303
name: negative regulation of cargo loading into COPII-coated vesicle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cargo loading into a COPII-coated vesicle." [GOC:lb, GOC:TermGenie, PMID:15899885]
synonym: "down regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "inhibition of cargo loading into COPII-coated vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "inhibition of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of COPII vesicle protein binding" NARROW [PMID:15899885]
synonym: "inhibition of protein sorting into COPII-coated vesicles" EXACT [PMID:15899885]
synonym: "negative regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1901301 ! regulation of cargo loading into COPII-coated vesicle
relationship: negatively_regulates GO:0090110 ! COPII-coated vesicle cargo loading

[Term]
id: GO:1901304
name: regulation of spermidine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie]
synonym: "regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "regulation of spermidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010967 ! regulation of polyamine biosynthetic process
relationship: regulates GO:0008295 ! spermidine biosynthetic process

[Term]
id: GO:1901305
name: negative regulation of spermidine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie]
synonym: "down regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of spermidine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:1901304 ! regulation of spermidine biosynthetic process
relationship: negatively_regulates GO:0008295 ! spermidine biosynthetic process

[Term]
id: GO:1901307
name: positive regulation of spermidine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie]
synonym: "activation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of spermidine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "activation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:1901304 ! regulation of spermidine biosynthetic process
relationship: positively_regulates GO:0008295 ! spermidine biosynthetic process

[Term]
id: GO:1901308
name: obsolete regulation of sterol regulatory element binding protein cleavage
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of SREBP cleavage" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901309
name: obsolete negative regulation of sterol regulatory element binding protein cleavage
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "down regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "down-regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "downregulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "downregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "inhibition of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "inhibition of SREBP processing" EXACT [GOC:bf]
synonym: "inhibition of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP cleavage" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901310
name: obsolete positive regulation of sterol regulatory element binding protein cleavage
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "activation of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "up regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "up regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "up-regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "up-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "upregulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "upregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901311
name: obsolete regulation of gene expression involved in extracellular matrix organization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie]
comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0010468

[Term]
id: GO:1901312
name: obsolete negative regulation of gene expression involved in extracellular matrix organization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie]
comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "down regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "down regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "down-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "downregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "downregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "inhibition of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "inhibition of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0010629

[Term]
id: GO:1901313
name: obsolete positive regulation of gene expression involved in extracellular matrix organization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie]
comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "activation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "activation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "activation of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "up regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "up regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "up-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "upregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "upregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0010628

[Term]
id: GO:1901314
name: obsolete regulation of histone H2A K63-linked ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1901315
name: obsolete negative regulation of histone H2A K63-linked ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901316
name: obsolete positive regulation of histone H2A K63-linked ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901317
name: regulation of flagellated sperm motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "regulation of sperm motility" BROAD []
synonym: "regulation of sperm movement" BROAD [GOC:TermGenie]
is_a: GO:0060295 ! regulation of cilium movement involved in cell motility
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0030317 ! flagellated sperm motility

[Term]
id: GO:1901318
name: negative regulation of flagellated sperm motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "down regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "down regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "down-regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "down-regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "downregulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "downregulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie]
synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie]
synonym: "negative regulation of sperm motility" BROAD []
synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie]
is_a: GO:0003354 ! negative regulation of cilium movement
is_a: GO:1901317 ! regulation of flagellated sperm motility
is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0030317 ! flagellated sperm motility

[Term]
id: GO:1901319
name: positive regulation of trehalose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trehalose catabolic process." [GOC:TermGenie]
synonym: "activation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "activation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "activation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "activation of trehalose catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "activation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0090062 ! regulation of trehalose metabolic process
relationship: positively_regulates GO:0005993 ! trehalose catabolic process

[Term]
id: GO:1901320
name: negative regulation of heart induction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart induction." [GOC:TermGenie]
synonym: "down regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "downregulation of heart induction" EXACT [GOC:TermGenie]
synonym: "inhibition of heart induction" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0090381 ! regulation of heart induction
relationship: negatively_regulates GO:0003129 ! heart induction

[Term]
id: GO:1901321
name: positive regulation of heart induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart induction." [GOC:TermGenie]
synonym: "activation of heart induction" NARROW [GOC:TermGenie]
synonym: "up regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "upregulation of heart induction" EXACT [GOC:TermGenie]
is_a: GO:0090381 ! regulation of heart induction
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
relationship: positively_regulates GO:0003129 ! heart induction

[Term]
id: GO:1901322
name: response to chloramphenicol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:TermGenie]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901323
name: response to erythromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901324
name: response to trichodermin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether

[Term]
id: GO:1901325
name: response to antimycin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901326
name: response to tetracycline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:TermGenie]
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1901327
name: response to tacrolimus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:TermGenie]
synonym: "response to FK506" EXACT [CHEBI:61057]
synonym: "response to tacrolimus hydrate" EXACT [CHEBI:61057]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901328
name: response to cytochalasin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901329
name: regulation of odontoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0071895 ! odontoblast differentiation

[Term]
id: GO:1901330
name: negative regulation of odontoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie]
synonym: "down regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of odontoblast differentiation" NARROW [GOC:TermGenie]
is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation
is_a: GO:1901329 ! regulation of odontoblast differentiation
relationship: negatively_regulates GO:0071895 ! odontoblast differentiation

[Term]
id: GO:1901331
name: positive regulation of odontoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie]
synonym: "activation of odontoblast differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of odontoblast differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901329 ! regulation of odontoblast differentiation
is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation
relationship: positively_regulates GO:0071895 ! odontoblast differentiation

[Term]
id: GO:1901332
name: negative regulation of lateral root development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral root development." [GOC:TermGenie]
synonym: "down regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "down-regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "downregulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "inhibition of lateral root development" NARROW [GOC:TermGenie]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000023 ! regulation of lateral root development
relationship: negatively_regulates GO:0048527 ! lateral root development

[Term]
id: GO:1901333
name: positive regulation of lateral root development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral root development." [GOC:TermGenie]
synonym: "activation of lateral root development" NARROW [GOC:TermGenie]
synonym: "up regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "up-regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "upregulation of lateral root development" EXACT [GOC:TermGenie]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:2000023 ! regulation of lateral root development
relationship: positively_regulates GO:0048527 ! lateral root development

[Term]
id: GO:1901334
name: lactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactone." [GOC:TermGenie]
synonym: "lactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901335
name: lactone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactone." [GOC:TermGenie]
synonym: "lactone breakdown" EXACT [GOC:TermGenie]
synonym: "lactone catabolism" EXACT [GOC:TermGenie]
synonym: "lactone degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:1901336
name: lactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactone." [GOC:TermGenie]
synonym: "lactone anabolism" EXACT [GOC:TermGenie]
synonym: "lactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "lactone formation" EXACT [GOC:TermGenie]
synonym: "lactone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:1901337
name: thioester transport
namespace: biological_process
def: "The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:1901338
name: catecholamine binding
namespace: molecular_function
def: "Binding to catecholamine." [GOC:TermGenie]
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:1901339
name: regulation of store-operated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1901340
name: negative regulation of store-operated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of store-operated calcium channel activity" NARROW [GOC:TermGenie]
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:1901339 ! regulation of store-operated calcium channel activity
is_a: GO:2001258 ! negative regulation of cation channel activity

[Term]
id: GO:1901341
name: positive regulation of store-operated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of store-operated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1901339 ! regulation of store-operated calcium channel activity
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:1901342
name: regulation of vasculature development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0001944 ! vasculature development

[Term]
id: GO:1901343
name: negative regulation of vasculature development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie]
synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
relationship: negatively_regulates GO:0001944 ! vasculature development

[Term]
id: GO:1901344
name: response to leptomycin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:1901345
name: response to L-thialysine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:TermGenie]
synonym: "response to thialysine" BROAD [GOC:mah]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901346
name: negative regulation of vasculature development involved in avascular cornea development in camera-type eye
namespace: biological_process
def: "Any negative regulation of vasculature development that is involved in developing an avascular cornea of a camera-type eye." [GOC:TermGenie, GOC:uh, PMID:16849433, PMID:17051153]
synonym: "down regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "down regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "down regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
synonym: "down regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "down-regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "down-regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
synonym: "down-regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "downregulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "downregulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
synonym: "downregulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "inhibition of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "inhibition of vasculature development involved in avascular cornea development" NARROW [GOC:TermGenie]
synonym: "inhibition of vasculature development involved in avascular cornea development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "negative regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "negative regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
is_a: GO:1901343 ! negative regulation of vasculature development
relationship: part_of GO:0036331 ! avascular cornea development in camera-type eye

[Term]
id: GO:1901347
name: negative regulation of secondary cell wall biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie]
synonym: "down regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "down regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "down regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "down regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "down-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "downregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "downregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "downregulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "downregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "inhibition of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "inhibition of secondary cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "inhibition of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "inhibition of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "negative regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2000652 ! regulation of secondary cell wall biogenesis
relationship: negatively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis

[Term]
id: GO:1901348
name: positive regulation of secondary cell wall biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie]
synonym: "activation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "activation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "activation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "activation of secondary cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "activation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "activation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "positive regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "up regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "up regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "up regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "up regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "up-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "upregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "upregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "upregulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "upregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2000652 ! regulation of secondary cell wall biogenesis
relationship: positively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis

[Term]
id: GO:1901349
name: glucosinolate transport
namespace: biological_process
def: "The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:1901350
name: obsolete cell-cell signaling involved in cell-cell junction organization
namespace: biological_process
def: "OBSOLETE. Any cell-cell signaling that is involved in cell-cell junction organization." [GOC:TermGenie]
comment: The reasons for obsoletion are that: (1) the term was created in 2012 and it had been used for only 1 NAS annotation (UniProt) since then; and (2)\nit can be represented as a GO-CAM.
synonym: "cell-cell signaling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "cell-cell signaling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie]
synonym: "cell-cell signaling involved in cell-cell junction organisation" EXACT [GOC:TermGenie]
synonym: "cell-cell signaling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction organisation" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction organization" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901351
name: regulation of phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188]
synonym: "regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0006655 ! phosphatidylglycerol biosynthetic process

[Term]
id: GO:1901352
name: negative regulation of phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188]
synonym: "down regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol formation" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process
relationship: negatively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process

[Term]
id: GO:1901353
name: positive regulation of phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188]
synonym: "activation of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol formation" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process
relationship: positively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process

[Term]
id: GO:1901354
name: response to L-canavanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus." [GOC:TermGenie]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901355
name: response to rapamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1901356
name: beta-D-galactofuranose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-D-galactofuranose." [GOC:di, GOC:TermGenie]
synonym: "beta-D-galactofuranose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006012 ! galactose metabolic process

[Term]
id: GO:1901357
name: beta-D-galactofuranose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-D-galactofuranose." [GOC:di, GOC:TermGenie]
synonym: "beta-D-galactofuranose breakdown" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose catabolism" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose degradation" EXACT [GOC:TermGenie]
is_a: GO:0019388 ! galactose catabolic process
is_a: GO:1901356 ! beta-D-galactofuranose metabolic process

[Term]
id: GO:1901358
name: beta-D-galactofuranose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-D-galactofuranose." [GOC:di, GOC:TermGenie]
synonym: "beta-D-galactofuranose anabolism" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose formation" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046369 ! galactose biosynthetic process
is_a: GO:1901356 ! beta-D-galactofuranose metabolic process

[Term]
id: GO:1901359
name: tungstate binding
namespace: molecular_function
def: "Binding to tungstate." [GOC:TermGenie]
is_a: GO:0043168 ! anion binding

[Term]
id: GO:1901360
name: obsolete organic cyclic compound metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901361
name: obsolete organic cyclic compound catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901362
name: obsolete organic cyclic compound biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901363
name: heterocyclic compound binding
namespace: molecular_function
def: "Binding to heterocyclic compound." [GOC:TermGenie]
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:1901364
name: funalenone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving funalenone." [GOC:di, GOC:TermGenie]
synonym: "funalenone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:1901365
name: funalenone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of funalenone." [GOC:di, GOC:TermGenie]
synonym: "funalenone breakdown" EXACT [GOC:TermGenie]
synonym: "funalenone catabolism" EXACT [GOC:TermGenie]
synonym: "funalenone degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1901364 ! funalenone metabolic process

[Term]
id: GO:1901366
name: funalenone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of funalenone." [GOC:di, GOC:TermGenie]
synonym: "funalenone anabolism" EXACT [GOC:TermGenie]
synonym: "funalenone biosynthesis" EXACT [GOC:TermGenie]
synonym: "funalenone formation" EXACT [GOC:TermGenie]
synonym: "funalenone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901364 ! funalenone metabolic process

[Term]
id: GO:1901367
name: response to L-cysteine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus." [GOC:TermGenie]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901369
name: cyclic 2,3-bisphospho-D-glycerate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid." [GOC:bf, GOC:crds, GOC:TermGenie, PMID:2226838]
synonym: "cDPG biosynthesis" EXACT [PMID:2226838]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid anabolism" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthetic process" EXACT [CHEBI:28699]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid formation" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid synthesis" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-diphosphoglycerate biosynthesis" EXACT [CHEBI:28699]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:1901370
name: response to glutathione
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:TermGenie]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901371
name: regulation of leaf morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf morphogenesis." [GOC:TermGenie]
is_a: GO:1900618 ! regulation of shoot system morphogenesis
is_a: GO:1905421 ! regulation of plant organ morphogenesis
relationship: regulates GO:0009965 ! leaf morphogenesis

[Term]
id: GO:1901372
name: obsolete trehalose biosynthetic process involved in ascospore formation
namespace: biological_process
def: "OBSOLETE. Any trehalose biosynthetic process that is involved in ascospore formation." [GOC:TermGenie]
comment: This term was obsoleted because it does not represent a specific pathway.
synonym: "mycose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mycose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mycose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mycose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mykose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mykose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mykose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mykose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose anabolism involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose anabolism involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose formation involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose formation involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose synthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose synthesis involved in ascospore formation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901373
name: lipid hydroperoxide transport
namespace: biological_process
def: "The directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:1901374
name: acetate ester transport
namespace: biological_process
def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0006810 ! transport

[Term]
id: GO:1901375
name: acetate ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901376
name: organic heteropentacyclic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic heteropentacyclic compound." [GOC:TermGenie]
synonym: "organic heteropentacyclic compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901377
name: organic heteropentacyclic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic heteropentacyclic compound." [GOC:TermGenie]
synonym: "organic heteropentacyclic compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:1901378
name: organic heteropentacyclic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic heteropentacyclic compound." [GOC:TermGenie]
synonym: "organic heteropentacyclic compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound formation" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:1901379
name: regulation of potassium ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of potassium ion membrane transport" EXACT []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: regulates GO:0071805 ! potassium ion transmembrane transport

[Term]
id: GO:1901380
name: negative regulation of potassium ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of potassium ion membrane transport" EXACT []
is_a: GO:0043267 ! negative regulation of potassium ion transport
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
relationship: negatively_regulates GO:0071805 ! potassium ion transmembrane transport

[Term]
id: GO:1901381
name: positive regulation of potassium ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie]
synonym: "activation of potassium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of potassium ion membrane transport" EXACT []
synonym: "up regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0043268 ! positive regulation of potassium ion transport
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
relationship: positively_regulates GO:0071805 ! potassium ion transmembrane transport

[Term]
id: GO:1901382
name: regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0097360 ! chorionic trophoblast cell proliferation

[Term]
id: GO:1901383
name: negative regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation
relationship: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation

[Term]
id: GO:1901384
name: positive regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation
relationship: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation

[Term]
id: GO:1901385
name: regulation of voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1901386
name: negative regulation of voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "down regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "down regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "down regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "downregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "downregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "inhibition of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity
is_a: GO:2001258 ! negative regulation of cation channel activity

[Term]
id: GO:1901387
name: positive regulation of voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "activation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "activation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "up regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "upregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "upregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:1901388
name: obsolete regulation of transforming growth factor beta activation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901389
name: obsolete negative regulation of transforming growth factor beta activation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "down regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901390
name: obsolete positive regulation of transforming growth factor beta activation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "activation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "activation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "activation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "activation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901392
name: obsolete regulation of transforming growth factor beta1 activation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901393
name: obsolete negative regulation of transforming growth factor beta1 activation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "down regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta1 activation" NARROW [GOC:TermGenie]
synonym: "inhibition of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901394
name: obsolete positive regulation of transforming growth factor beta1 activation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "activation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "activation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta1 activation" NARROW [GOC:TermGenie]
synonym: "activation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901395
name: obsolete regulation of transforming growth factor beta2 activation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901396
name: obsolete negative regulation of transforming growth factor beta2 activation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "down regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta2 activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901397
name: obsolete positive regulation of transforming growth factor beta2 activation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function
synonym: "activation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta2 activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901398
name: obsolete regulation of transforming growth factor beta3 activation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901399
name: obsolete negative regulation of transforming growth factor beta3 activation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "down regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta3 activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901400
name: obsolete positive regulation of transforming growth factor beta3 activation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie]
comment: The reason for obsoletion is that this represents a molecular function.
synonym: "activation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta3 activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901401
name: regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:1901402
name: negative regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
relationship: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:1901403
name: positive regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
relationship: positively_regulates GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:1901404
name: regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
relationship: regulates GO:0033015 ! tetrapyrrole catabolic process

[Term]
id: GO:1901405
name: negative regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
relationship: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process

[Term]
id: GO:1901406
name: positive regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
relationship: positively_regulates GO:0033015 ! tetrapyrrole catabolic process

[Term]
id: GO:1901407
name: obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:1901408
name: obsolete negative regulation of phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "down-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "downregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "downregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "inhibition of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "inhibition of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie]
synonym: "negative regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "negative regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "negative regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:1901409
name: obsolete positive regulation of phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "activation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "activation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "activation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "activation of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie]
synonym: "positive regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "upregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901410
name: regulation of tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
relationship: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate

[Term]
id: GO:1901411
name: negative regulation of tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
is_a: GO:2000212 ! negative regulation of glutamate metabolic process
relationship: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate

[Term]
id: GO:1901412
name: positive regulation of tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
is_a: GO:2000213 ! positive regulation of glutamate metabolic process
relationship: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate

[Term]
id: GO:1901413
name: regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
relationship: regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA

[Term]
id: GO:1901414
name: negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
relationship: negatively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA

[Term]
id: GO:1901415
name: positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
relationship: positively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA

[Term]
id: GO:1901416
name: regulation of response to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901419 ! regulation of response to alcohol
relationship: regulates GO:0045471 ! response to ethanol

[Term]
id: GO:1901417
name: negative regulation of response to ethanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ethanol" NARROW [GOC:TermGenie]
is_a: GO:1901416 ! regulation of response to ethanol
is_a: GO:1901420 ! negative regulation of response to alcohol
relationship: negatively_regulates GO:0045471 ! response to ethanol

[Term]
id: GO:1901418
name: positive regulation of response to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to ethanol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ethanol" EXACT [GOC:TermGenie]
is_a: GO:1901416 ! regulation of response to ethanol
is_a: GO:1901421 ! positive regulation of response to alcohol
relationship: positively_regulates GO:0045471 ! response to ethanol

[Term]
id: GO:1901419
name: regulation of response to alcohol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0097305 ! response to alcohol

[Term]
id: GO:1901420
name: negative regulation of response to alcohol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to alcohol" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901419 ! regulation of response to alcohol
relationship: negatively_regulates GO:0097305 ! response to alcohol

[Term]
id: GO:1901421
name: positive regulation of response to alcohol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to alcohol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to alcohol" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901419 ! regulation of response to alcohol
relationship: positively_regulates GO:0097305 ! response to alcohol

[Term]
id: GO:1901422
name: response to butan-1-ol
namespace: biological_process
alt_id: GO:1990336
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie, PMID:24014527]
synonym: "process resulting in tolerance to butan-1-ol" NARROW []
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:1901423
name: response to benzene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1901424
name: response to toluene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1901425
name: response to formic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901426
name: response to furfural
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901427
name: response to propan-1-ol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:1901428
name: regulation of syringal lignin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie]
synonym: "regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901141 ! regulation of lignin biosynthetic process
relationship: regulates GO:1901066 ! syringal lignin biosynthetic process

[Term]
id: GO:1901429
name: negative regulation of syringal lignin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process
relationship: negatively_regulates GO:1901066 ! syringal lignin biosynthetic process

[Term]
id: GO:1901430
name: positive regulation of syringal lignin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie]
synonym: "activation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process
relationship: positively_regulates GO:1901066 ! syringal lignin biosynthetic process

[Term]
id: GO:1901431
name: regulation of response to cycloalkane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0014071 ! response to cycloalkane

[Term]
id: GO:1901432
name: negative regulation of response to cycloalkane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "downregulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "inhibition of response to cycloalkane" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901431 ! regulation of response to cycloalkane
relationship: negatively_regulates GO:0014071 ! response to cycloalkane

[Term]
id: GO:1901433
name: positive regulation of response to cycloalkane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to cycloalkane" NARROW [GOC:TermGenie]
synonym: "up regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "upregulation of response to cycloalkane" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901431 ! regulation of response to cycloalkane
relationship: positively_regulates GO:0014071 ! response to cycloalkane

[Term]
id: GO:1901434
name: regulation of toluene catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of toluene degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:1901437 ! regulation of toluene metabolic process
relationship: regulates GO:0042203 ! toluene catabolic process

[Term]
id: GO:1901435
name: negative regulation of toluene catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:1901434 ! regulation of toluene catabolic process
is_a: GO:1901438 ! negative regulation of toluene metabolic process
relationship: negatively_regulates GO:0042203 ! toluene catabolic process

[Term]
id: GO:1901436
name: positive regulation of toluene catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "activation of toluene catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "activation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1901434 ! regulation of toluene catabolic process
is_a: GO:1901439 ! positive regulation of toluene metabolic process
relationship: positively_regulates GO:0042203 ! toluene catabolic process

[Term]
id: GO:1901437
name: regulation of toluene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of toluene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0018970 ! toluene metabolic process

[Term]
id: GO:1901438
name: negative regulation of toluene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1901437 ! regulation of toluene metabolic process
relationship: negatively_regulates GO:0018970 ! toluene metabolic process

[Term]
id: GO:1901439
name: positive regulation of toluene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "activation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "activation of toluene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1901437 ! regulation of toluene metabolic process
relationship: positively_regulates GO:0018970 ! toluene metabolic process

[Term]
id: GO:1901440
name: poly(hydroxyalkanoate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901441
name: poly(hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) formation" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process

[Term]
id: GO:1901442
name: regulation of response to furfural
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:1901426 ! response to furfural

[Term]
id: GO:1901443
name: negative regulation of response to furfural
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "downregulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "inhibition of response to furfural" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901442 ! regulation of response to furfural
relationship: negatively_regulates GO:1901426 ! response to furfural

[Term]
id: GO:1901444
name: positive regulation of response to furfural
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to furfural" NARROW [GOC:TermGenie]
synonym: "up regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "upregulation of response to furfural" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901442 ! regulation of response to furfural
relationship: positively_regulates GO:1901426 ! response to furfural

[Term]
id: GO:1901445
name: regulation of response to propan-1-ol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901419 ! regulation of response to alcohol
relationship: regulates GO:1901427 ! response to propan-1-ol

[Term]
id: GO:1901446
name: negative regulation of response to propan-1-ol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to propan-1-ol" NARROW [GOC:TermGenie]
is_a: GO:1901420 ! negative regulation of response to alcohol
is_a: GO:1901445 ! regulation of response to propan-1-ol
relationship: negatively_regulates GO:1901427 ! response to propan-1-ol

[Term]
id: GO:1901447
name: positive regulation of response to propan-1-ol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to propan-1-ol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to propan-1-ol" EXACT [GOC:TermGenie]
is_a: GO:1901421 ! positive regulation of response to alcohol
is_a: GO:1901445 ! regulation of response to propan-1-ol
relationship: positively_regulates GO:1901427 ! response to propan-1-ol

[Term]
id: GO:1901448
name: regulation of response to butan-1-ol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901419 ! regulation of response to alcohol
relationship: regulates GO:1901422 ! response to butan-1-ol

[Term]
id: GO:1901449
name: negative regulation of response to butan-1-ol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to butan-1-ol" NARROW [GOC:TermGenie]
is_a: GO:1901420 ! negative regulation of response to alcohol
is_a: GO:1901448 ! regulation of response to butan-1-ol
relationship: negatively_regulates GO:1901422 ! response to butan-1-ol

[Term]
id: GO:1901450
name: positive regulation of response to butan-1-ol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to butan-1-ol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to butan-1-ol" EXACT [GOC:TermGenie]
is_a: GO:1901421 ! positive regulation of response to alcohol
is_a: GO:1901448 ! regulation of response to butan-1-ol
relationship: positively_regulates GO:1901422 ! response to butan-1-ol

[Term]
id: GO:1901451
name: regulation of response to benzene
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:1901423 ! response to benzene

[Term]
id: GO:1901452
name: negative regulation of response to benzene
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "downregulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "inhibition of response to benzene" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901451 ! regulation of response to benzene
relationship: negatively_regulates GO:1901423 ! response to benzene

[Term]
id: GO:1901453
name: positive regulation of response to benzene
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to benzene" NARROW [GOC:TermGenie]
synonym: "up regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "upregulation of response to benzene" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901451 ! regulation of response to benzene
relationship: positively_regulates GO:1901423 ! response to benzene

[Term]
id: GO:1901454
name: regulation of response to toluene
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:1901424 ! response to toluene

[Term]
id: GO:1901455
name: negative regulation of response to toluene
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "downregulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "inhibition of response to toluene" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901454 ! regulation of response to toluene
relationship: negatively_regulates GO:1901424 ! response to toluene

[Term]
id: GO:1901456
name: positive regulation of response to toluene
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to toluene" NARROW [GOC:TermGenie]
synonym: "up regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "upregulation of response to toluene" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901454 ! regulation of response to toluene
relationship: positively_regulates GO:1901424 ! response to toluene

[Term]
id: GO:1901457
name: regulation of response to acetate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0010034 ! response to acetate

[Term]
id: GO:1901458
name: negative regulation of response to acetate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "downregulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "inhibition of response to acetate" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901457 ! regulation of response to acetate
relationship: negatively_regulates GO:0010034 ! response to acetate

[Term]
id: GO:1901459
name: positive regulation of response to acetate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to acetate" NARROW [GOC:TermGenie]
synonym: "up regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "upregulation of response to acetate" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901457 ! regulation of response to acetate
relationship: positively_regulates GO:0010034 ! response to acetate

[Term]
id: GO:1901460
name: regulation of response to formic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:1901425 ! response to formic acid

[Term]
id: GO:1901461
name: negative regulation of response to formic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of response to formic acid" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901460 ! regulation of response to formic acid
relationship: negatively_regulates GO:1901425 ! response to formic acid

[Term]
id: GO:1901462
name: positive regulation of response to formic acid
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to formic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of response to formic acid" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901460 ! regulation of response to formic acid
relationship: positively_regulates GO:1901425 ! response to formic acid

[Term]
id: GO:1901463
name: regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
relationship: regulates GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:1901464
name: negative regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
relationship: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:1901465
name: positive regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
relationship: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:1901466
name: regulation of ferulate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:1901067 ! ferulate catabolic process

[Term]
id: GO:1901467
name: negative regulation of ferulate catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of ferulate catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901466 ! regulation of ferulate catabolic process
relationship: negatively_regulates GO:1901067 ! ferulate catabolic process

[Term]
id: GO:1901468
name: positive regulation of ferulate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "activation of ferulate catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1901466 ! regulation of ferulate catabolic process
relationship: positively_regulates GO:1901067 ! ferulate catabolic process

[Term]
id: GO:1901469
name: regulation of syringal lignin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
relationship: regulates GO:1901065 ! syringal lignin catabolic process

[Term]
id: GO:1901470
name: negative regulation of syringal lignin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:1901469 ! regulation of syringal lignin catabolic process
relationship: negatively_regulates GO:1901065 ! syringal lignin catabolic process

[Term]
id: GO:1901471
name: positive regulation of syringal lignin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1901469 ! regulation of syringal lignin catabolic process
relationship: positively_regulates GO:1901065 ! syringal lignin catabolic process

[Term]
id: GO:1901472
name: regulation of Golgi calcium ion export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi calcium ion export." [GOC:TermGenie]
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
relationship: regulates GO:0061454 ! release of sequestered calcium ion into cytosol by Golgi

[Term]
id: GO:1901474
name: azole transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0045118
def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]
synonym: "azole transporter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901475
name: pyruvate transmembrane transport
namespace: biological_process
def: "The directed movement of pyruvate across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "pyruvate membrane transport" EXACT []
is_a: GO:0006848 ! pyruvate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1901477
name: obsolete benomyl transmembrane transport
namespace: biological_process
def: "OBSOLETE. The directed movement of benomyl across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.\nThis term is out of scope for GO.
synonym: "benomyl membrane transport" EXACT []
is_obsolete: true

[Term]
id: GO:1901478
name: aminotriazole transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015241
def: "Enables the transfer of amitrole from one side of a membrane to the other." [GOC:TermGenie]
synonym: "aminotriazole transporter activity" BROAD []
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:1901479
name: obsolete benomyl transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015242
def: "OBSOLETE. Enables the transfer of benomyl from one side of a membrane to the other." [GOC:TermGenie]
comment: The reason for obsoletion is that these terms are beyond the scope of GO.
synonym: "benomyl transporter activity" RELATED []
is_obsolete: true

[Term]
id: GO:1901480
name: oleate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oleate from one side of a membrane to the other." [GOC:TermGenie, PMID:19493158]
synonym: "oleate transporter activity" RELATED []
is_a: GO:0005324 ! long-chain fatty acid transmembrane transporter activity

[Term]
id: GO:1901481
name: L-glutamate import involved in cellular response to nitrogen starvation
namespace: biological_process
def: "Any L-glutamate import that is involved in cellular response to nitrogen starvation." [GOC:TermGenie]
synonym: "L-glutamate uptake involved in cellular response to nitrogen starvation" EXACT [GOC:TermGenie]
is_a: GO:0051938 ! L-glutamate import
relationship: part_of GO:0006995 ! cellular response to nitrogen starvation

[Term]
id: GO:1901482
name: L-lysine import into vacuole involved in cellular response to nitrogen starvation
namespace: biological_process
def: "A L-lysine import into the vacuole that is involved in cellular response to nitrogen starvation." [GOC:TermGenie]
is_a: GO:0090517 ! L-lysine transmembrane import into vacuole
relationship: part_of GO:0006995 ! cellular response to nitrogen starvation

[Term]
id: GO:1901483
name: obsolete regulation of transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559]
comment: The reason for obsoletion is that the regulated target process does not represent a specific pathway.
synonym: "regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of transcription factor degradation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0032434

[Term]
id: GO:1901484
name: obsolete negative regulation of transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw]
comment: The reason for obsoletion is that the regulated target process does not represent a specific pathway.
synonym: "down regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription factor catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription factor degradation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0032435

[Term]
id: GO:1901485
name: obsolete positive regulation of transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559]
comment: The reason for obsoletion is that the regulated target process does not represent a specific pathway.
synonym: "activation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "activation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "activation of transcription factor catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "activation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor degradation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0032436

[Term]
id: GO:1901486
name: obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. Positive regulation of transcription factor catabolism that results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
comment: The reason for obsoletion is that this term should be represented by a GO-CAM model.
synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation" NARROW [GOC:bf]
synonym: "negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolism" EXACT [GOC:bf]
synonym: "negative regulation of SREBP-mediated signaling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901487
name: obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels
namespace: biological_process
def: "OBSOLETE. Positive regulation of transcription factor catabolism in response to increased oxygen levels, which results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
comment: The reason for obsoletion is that this is better captured in a GO-CAM model.
synonym: "negative regulation of SREBP signaling by acceleration of SREBP degradation, in response to increased oxygen levels" NARROW [PMID:22833559]
synonym: "negative regulation of SREBP signaling by positive regulation of transcription factor catabolism in response to increased oxygen levels" EXACT [GOC:bf]
synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation, in response to elevated oxygen" NARROW [GOC:bf]
synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen by positive regulation of transcription factor catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901488
name: obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process
namespace: biological_process
def: "OBSOLETE. Negative regulation of transcription factor catabolism that results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
comment: The reason for obsoletion is that this term should be represented by a GO-CAM model.
synonym: "positive regulation of SREBP signaling pathway by inhibition of SREBP degradation" NARROW [PMID:22833559]
synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation" NARROW [PMID:22833559]
synonym: "positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolism" EXACT [GOC:bf]
synonym: "positive regulation of SREBP-mediated signaling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of SREBP-mediated signalling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901489
name: obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process in response to decreased oxygen levels
namespace: biological_process
def: "OBSOLETE. Negative regulation of transcription factor catabolism in response to decreased oxygen levels, which results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
comment: The reason for obsoletion is that this term should be represented by a GO-CAM model.
synonym: "positive regulation of SREBP signaling by inhibition of SREBP degradation in response to decreased oxygen levels" EXACT [GOC:bf]
synonym: "positive regulation of SREBP signaling by negative regulation of transcription factor catabolism at low oxygen levels" EXACT [GOC:bf]
synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation, in response to decreased oxygen" NARROW [PMID:22833559]
synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen by negative regulation of transcription factor catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901490
name: regulation of lymphangiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819]
synonym: "regulation of lymph vessel formation" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0001946 ! lymphangiogenesis

[Term]
id: GO:1901491
name: negative regulation of lymphangiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819]
synonym: "down regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "down regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of lymph vessel formation" NARROW [GOC:TermGenie]
synonym: "inhibition of lymphangiogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of lymph vessel formation" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901490 ! regulation of lymphangiogenesis
relationship: negatively_regulates GO:0001946 ! lymphangiogenesis

[Term]
id: GO:1901492
name: positive regulation of lymphangiogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819]
synonym: "activation of lymph vessel formation" NARROW [GOC:TermGenie]
synonym: "activation of lymphangiogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "up regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "up regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "upregulation of lymphangiogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901490 ! regulation of lymphangiogenesis
relationship: positively_regulates GO:0001946 ! lymphangiogenesis

[Term]
id: GO:1901493
name: response to decalin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decalin stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1901494
name: regulation of cysteine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie]
synonym: "regulation of cysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
relationship: regulates GO:0006534 ! cysteine metabolic process

[Term]
id: GO:1901495
name: negative regulation of cysteine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie]
synonym: "down regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of cysteine metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cysteine metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of cysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:1901494 ! regulation of cysteine metabolic process
relationship: negatively_regulates GO:0006534 ! cysteine metabolic process

[Term]
id: GO:1901496
name: positive regulation of cysteine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie]
synonym: "activation of cysteine metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cysteine metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:1901494 ! regulation of cysteine metabolic process
relationship: positively_regulates GO:0006534 ! cysteine metabolic process

[Term]
id: GO:1901497
name: response to diphenyl ether
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenyl ether stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether

[Term]
id: GO:1901498
name: response to tetralin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetralin stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1901499
name: response to hexane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1902778 ! response to alkane

[Term]
id: GO:1901500
name: response to p-xylene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a p-xylene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901501 ! response to xylene

[Term]
id: GO:1901501
name: response to xylene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xylene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1901502
name: ether catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ether." [GOC:pr, GOC:TermGenie]
synonym: "ether breakdown" EXACT [GOC:TermGenie]
synonym: "ether catabolism" EXACT [GOC:TermGenie]
synonym: "ether degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:1901503
name: ether biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ether." [GOC:pr, GOC:TermGenie]
synonym: "ether anabolism" EXACT [GOC:TermGenie]
synonym: "ether biosynthesis" EXACT [GOC:TermGenie]
synonym: "ether formation" EXACT [GOC:TermGenie]
synonym: "ether synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:1901504
name: triazole transport
namespace: biological_process
def: "The directed movement of a triazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:1901505
name: carbohydrate derivative transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "carbohydrate derivative transporter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901506
name: regulation of acylglycerol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie]
synonym: "regulation of glyceride transport" EXACT [GOC:TermGenie]
is_a: GO:0032368 ! regulation of lipid transport
relationship: regulates GO:0034196 ! acylglycerol transport

[Term]
id: GO:1901507
name: negative regulation of acylglycerol transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "down regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "downregulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "downregulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "inhibition of acylglycerol transport" NARROW [GOC:TermGenie]
synonym: "inhibition of glyceride transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of glyceride transport" EXACT [GOC:TermGenie]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:1901506 ! regulation of acylglycerol transport
relationship: negatively_regulates GO:0034196 ! acylglycerol transport

[Term]
id: GO:1901508
name: positive regulation of acylglycerol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie]
synonym: "activation of acylglycerol transport" NARROW [GOC:TermGenie]
synonym: "activation of glyceride transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "up regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "up regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "upregulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "upregulation of glyceride transport" EXACT [GOC:TermGenie]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:1901506 ! regulation of acylglycerol transport
relationship: positively_regulates GO:0034196 ! acylglycerol transport

[Term]
id: GO:1901509
name: regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie]
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0061154 ! endothelial tube morphogenesis

[Term]
id: GO:1901510
name: (-)-microperfuranone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-microperfuranone." [GOC:di, GOC:TermGenie]
synonym: "(-)-microperfuranone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:1901511
name: (-)-microperfuranone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone." [GOC:di, GOC:TermGenie]
synonym: "(-)-microperfuranone breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone degradation" EXACT [GOC:TermGenie]
is_a: GO:1901335 ! lactone catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901510 ! (-)-microperfuranone metabolic process

[Term]
id: GO:1901512
name: (-)-microperfuranone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-microperfuranone." [GOC:di, GOC:TermGenie]
synonym: "(-)-microperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone formation" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901510 ! (-)-microperfuranone metabolic process

[Term]
id: GO:1901513
name: lipo-chitin oligosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901514
name: ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out)." [GOC:TermGenie]
synonym: "lipo-chitin oligosaccharide transmembrane-transporting ATPase activity" RELATED []
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
is_a: GO:1901513 ! lipo-chitin oligosaccharide transmembrane transporter activity

[Term]
id: GO:1901515
name: poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other." [GOC:TermGenie, PMID:15090514, PMID:18359807]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901516
name: aspyridone A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aspyridone A." [GOC:di, GOC:TermGenie]
synonym: "aspyridone A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:1901517
name: aspyridone A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aspyridone A." [GOC:di, GOC:TermGenie]
synonym: "aspyridone A breakdown" EXACT [GOC:TermGenie]
synonym: "aspyridone A catabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone A degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901516 ! aspyridone A metabolic process

[Term]
id: GO:1901518
name: aspyridone A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aspyridone A." [GOC:di, GOC:TermGenie]
synonym: "aspyridone A anabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone A biosynthesis" EXACT [GOC:TermGenie]
synonym: "aspyridone A formation" EXACT [GOC:TermGenie]
synonym: "aspyridone A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1901516 ! aspyridone A metabolic process

[Term]
id: GO:1901519
name: aspyridone B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aspyridone B." [GOC:di, GOC:TermGenie]
synonym: "aspyridone B metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:1901520
name: aspyridone B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aspyridone B." [GOC:di, GOC:TermGenie]
synonym: "aspyridone B breakdown" EXACT [GOC:TermGenie]
synonym: "aspyridone B catabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone B degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901519 ! aspyridone B metabolic process

[Term]
id: GO:1901521
name: aspyridone B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aspyridone B." [GOC:di, GOC:TermGenie]
synonym: "aspyridone B anabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone B biosynthesis" EXACT [GOC:TermGenie]
synonym: "aspyridone B formation" EXACT [GOC:TermGenie]
synonym: "aspyridone B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1901519 ! aspyridone B metabolic process

[Term]
id: GO:1901522
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0045944
consider: GO:0070887

[Term]
id: GO:1901523
name: icosanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of icosanoid." [GOC:pr, GOC:TermGenie]
synonym: "icosanoid breakdown" EXACT [GOC:TermGenie]
synonym: "icosanoid catabolism" EXACT [GOC:TermGenie]
synonym: "icosanoid degradation" EXACT [GOC:TermGenie]
is_a: GO:1901569 ! fatty acid derivative catabolic process

[Term]
id: GO:1901524
name: regulation of mitophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macromitophagy." [GOC:TermGenie]
synonym: "regulation of macromitophagy" EXACT []
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:1903146 ! regulation of autophagy of mitochondrion
relationship: regulates GO:0000423 ! mitophagy

[Term]
id: GO:1901525
name: negative regulation of mitophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy." [GOC:TermGenie]
synonym: "down regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of macromitophagy" NARROW [GOC:TermGenie]
synonym: "negative regulation of macromitophagy" EXACT []
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:1901524 ! regulation of mitophagy
is_a: GO:1903147 ! negative regulation of autophagy of mitochondrion
relationship: negatively_regulates GO:0000423 ! mitophagy

[Term]
id: GO:1901526
name: positive regulation of mitophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitophagy." [GOC:TermGenie]
synonym: "activation of macromitophagy" NARROW [GOC:TermGenie]
synonym: "positive regulation of macromitophagy" EXACT []
synonym: "up regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of macromitophagy" EXACT [GOC:TermGenie]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:1901524 ! regulation of mitophagy
is_a: GO:1903599 ! positive regulation of autophagy of mitochondrion
relationship: positively_regulates GO:0000423 ! mitophagy

[Term]
id: GO:1901527
name: abscisic acid-activated signaling pathway involved in stomatal movement
namespace: biological_process
def: "Any abscisic acid mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie, PMID:22730405]
synonym: "abscisic acid mediated signaling pathway involved in stomatal movement" RELATED []
synonym: "abscisic acid mediated signalling involved in stomatal movement" EXACT [GOC:TermGenie]
is_a: GO:0009738 ! abscisic acid-activated signaling pathway
relationship: part_of GO:0010118 ! stomatal movement

[Term]
id: GO:1901528
name: obsolete hydrogen peroxide mediated signaling pathway involved in stomatal movement
namespace: biological_process
def: "OBSOLETE. Any hydrogen peroxide mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie]
comment: This term was obsoleted because it represents a pre-composed term that should be captured as a GO-CAM model.
synonym: "H2O2 mediated signaling pathway involved in stomatal movement" EXACT [GOC:TermGenie]
synonym: "hydrogen peroxide mediated signalling pathway involved in stomatal movement" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0034599

[Term]
id: GO:1901529
name: positive regulation of anion channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anion channel activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of anion channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of anion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of anion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of anion channel activity" EXACT [GOC:TermGenie]
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1903961 ! positive regulation of anion transmembrane transport

[Term]
id: GO:1901530
name: response to hypochlorite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus." [GOC:pr, GOC:TermGenie, PMID:22223481]
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:1901531
name: hypochlorite binding
namespace: molecular_function
def: "Binding to hypochlorite." [GOC:pr, GOC:TermGenie, PMID:22223481]
is_a: GO:0043168 ! anion binding

[Term]
id: GO:1901532
name: regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0002244 ! hematopoietic progenitor cell differentiation

[Term]
id: GO:1901533
name: negative regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
relationship: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation

[Term]
id: GO:1901534
name: positive regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT []
synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
relationship: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation

[Term]
id: GO:1901535
name: obsolete regulation of DNA demethylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0141166
consider: GO:0141167
consider: GO:0141169

[Term]
id: GO:1901536
name: obsolete negative regulation of DNA demethylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA demethylation" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0141166
consider: GO:0141167
consider: GO:0141168
consider: GO:0141169

[Term]
id: GO:1901537
name: obsolete positive regulation of DNA demethylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of DNA demethylation" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA demethylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0141166
consider: GO:0141167
consider: GO:0141168
consider: GO:0141169

[Term]
id: GO:1901538
name: obsolete changes to DNA methylation involved in embryo development
namespace: biological_process
def: "OBSOLETE. The addition or removal of methyl groups to DNA that contributes to the epigenetic regulation of embryonic gene expression." [GOC:TermGenie]
comment: The reason for obsoletion is that this term mixes a cellular process with a developmental phase, without describing a specific pathway.
synonym: "changes in DNA methylation involved in embryo development" EXACT [GOC:TermGenie]
synonym: "changes in DNA methylation involved in embryogenesis" EXACT [GOC:TermGenie]
synonym: "changes in DNA methylation involved in embryonal development" RELATED [GOC:TermGenie]
synonym: "DNA methylation or demethylation involved in embryogenesis" EXACT [GOC:TermGenie]
synonym: "DNA methylation or demethylation involved in embryonal development" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901539
name: ent-pimara-8(14),15-diene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:1901540
name: ent-pimara-8(14),15-diene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene breakdown" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene catabolism" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene degradation" EXACT [GOC:TermGenie]
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process

[Term]
id: GO:1901541
name: ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process

[Term]
id: GO:1901542
name: regulation of ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process

[Term]
id: GO:1901543
name: negative regulation of ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process
relationship: negatively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process

[Term]
id: GO:1901544
name: positive regulation of ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process
relationship: positively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process

[Term]
id: GO:1901545
name: response to raffinose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:TermGenie]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:1901546
name: regulation of synaptic vesicle lumen acidification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie]
subset: goslim_synapse
synonym: "regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "regulation of synaptic vesicle lumen proton loading" EXACT syngo_official_label []
is_a: GO:0010155 ! regulation of proton transport
relationship: regulates GO:0097401 ! synaptic vesicle lumen acidification

[Term]
id: GO:1901547
name: negative regulation of synaptic vesicle lumen acidification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie]
synonym: "negative regulation of proton loading" EXACT syngo_official_label []
synonym: "negative regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
relationship: negatively_regulates GO:0097401 ! synaptic vesicle lumen acidification

[Term]
id: GO:1901548
name: positive regulation of synaptic vesicle lumen acidification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie]
synonym: "activation of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie]
synonym: "positive regulation of proton loading" EXACT syngo_official_label []
synonym: "positive regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
relationship: positively_regulates GO:0097401 ! synaptic vesicle lumen acidification

[Term]
id: GO:1901550
name: regulation of endothelial cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
is_a: GO:0045601 ! regulation of endothelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0001885 ! endothelial cell development

[Term]
id: GO:1901551
name: negative regulation of endothelial cell development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:1901550 ! regulation of endothelial cell development
relationship: negatively_regulates GO:0001885 ! endothelial cell development

[Term]
id: GO:1901552
name: positive regulation of endothelial cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1901550 ! regulation of endothelial cell development
relationship: positively_regulates GO:0001885 ! endothelial cell development

[Term]
id: GO:1901553
name: malonic acid transmembrane transport
namespace: biological_process
def: "The directed movement of malonic acid across a membrane." [GOC:al, GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "malonic acid membrane transport" EXACT []
is_a: GO:1900752 ! malonic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1901554
name: response to paracetamol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus." [GOC:TermGenie]
synonym: "response to acetaminophen" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901555
name: obsolete response to paclitaxel
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GOC:TermGenie]
comment: This term was obsoleted because it represents a response to xenobiotic stimulus, and GO terms are not created for every xenobiotic.
is_obsolete: true
replaced_by: GO:0009410

[Term]
id: GO:1901556
name: response to candesartan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901557
name: response to fenofibrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1901558
name: response to metformin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus." [GOC:TermGenie]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1901559
name: response to ribavirin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901560
name: response to purvalanol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:TermGenie]
is_a: GO:0014074 ! response to purine-containing compound

[Term]
id: GO:1901561
name: obsolete response to benomyl
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:TermGenie]
comment: This term is out of scope for GO.
is_obsolete: true

[Term]
id: GO:1901562
name: response to paraquat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:TermGenie]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1901563
name: response to camptothecin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie]
synonym: "response to CPT" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:1901564
name: obsolete organonitrogen compound metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:1901565
name: obsolete organonitrogen compound catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:1901566
name: obsolete organonitrogen compound biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true

[Term]
id: GO:1901567
name: fatty acid derivative binding
namespace: molecular_function
def: "Binding to fatty acid derivative." [GOC:pr, GOC:TermGenie]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:1901568
name: fatty acid derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acid derivative." [GOC:pr, GOC:TermGenie]
synonym: "fatty acid derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:1901569
name: fatty acid derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty acid derivative." [GOC:pr, GOC:TermGenie]
synonym: "fatty acid derivative breakdown" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative catabolism" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:1901570
name: fatty acid derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acid derivative." [GOC:pr, GOC:TermGenie]
synonym: "fatty acid derivative anabolism" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative formation" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:1901571
name: fatty acid derivative transport
namespace: biological_process
def: "The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:1901572
name: obsolete chemical substance metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving chemical substance." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemical substance metabolic process" EXACT []
synonym: "chemical substance metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901573
name: obsolete chemical substance catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chemical substance." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemical substance breakdown" EXACT [GOC:TermGenie]
synonym: "chemical substance catabolic process" EXACT []
synonym: "chemical substance catabolism" EXACT [GOC:TermGenie]
synonym: "chemical substance degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901574
name: obsolete chemical substance biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of chemical substance." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemical substance anabolism" EXACT [GOC:TermGenie]
synonym: "chemical substance biosynthesis" EXACT [GOC:TermGenie]
synonym: "chemical substance biosynthetic process" EXACT []
synonym: "chemical substance formation" EXACT [GOC:TermGenie]
synonym: "chemical substance synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901575
name: obsolete organic substance catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "organic molecular entity catabolic process" EXACT []
synonym: "organic substance breakdown" EXACT []
synonym: "organic substance catabolism" EXACT []
synonym: "organic substance degradation" EXACT []
is_obsolete: true

[Term]
id: GO:1901576
name: obsolete organic substance biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]
comment: The reason for obsoletion is that this term is an unnecessary grouping term.
synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie]
synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic molecular entity biosynthetic process" EXACT []
synonym: "organic molecular entity formation" EXACT [GOC:TermGenie]
synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie]
synonym: "organic substance anabolism" EXACT []
synonym: "organic substance biosynthesis" EXACT []
synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_obsolete: true

[Term]
id: GO:1901577
name: regulation of alkane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie]
synonym: "regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "regulation of alkane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0043447 ! alkane biosynthetic process

[Term]
id: GO:1901578
name: negative regulation of alkane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of alkane formation" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: negatively_regulates GO:0043447 ! alkane biosynthetic process

[Term]
id: GO:1901579
name: positive regulation of alkane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie]
synonym: "activation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "activation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of alkane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of alkane formation" EXACT [GOC:TermGenie]
synonym: "activation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
relationship: positively_regulates GO:0043447 ! alkane biosynthetic process

[Term]
id: GO:1901580
name: obsolete regulation of telomeric RNA transcription from RNA pol II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that telomeric RNA is specifically transcribed, but it may be a result of cryptic transcription. Biological processes exist to maintain telomeric DNA is a repressed state (subtelomeric heterochromatin formation ; GO:0031509).
synonym: "regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0031509

[Term]
id: GO:1901581
name: obsolete negative regulation of telomeric RNA transcription from RNA pol II promoter
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that telomeric RNA is specifically transcribed, but it may be a result of cryptic transcription. Biological processes exist to maintain telomeric DNA is a repressed state (subtelomeric heterochromatin formation ; GO:0031509).
synonym: "down regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0031509

[Term]
id: GO:1901582
name: obsolete positive regulation of telomeric RNA transcription from RNA pol II promoter
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that telomeric RNA is specifically transcribed, but it may be a result of cryptic transcription. Biological processes exist to maintain telomeric DNA is a repressed state (subtelomeric heterochromatin formation ; GO:0031509).
synonym: "activation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "activation of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901583
name: tetrapeptide import across plasma membrane
namespace: biological_process
def: "The directed movement of a tetrapeptide from outside of a cell, across the plasma membrane and into the cytosol." [GOC:TermGenie, PMID:22226946]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "tetrapeptide membrane transport" EXACT []
synonym: "tetrapeptide transmembrane transport" BROAD []
is_a: GO:0140205 ! oligopeptide import across plasma membrane

[Term]
id: GO:1901584
name: tetrapeptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tetrapeptide from one side of a membrane to the other." [GOC:TermGenie]
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity

[Term]
id: GO:1901585
name: obsolete regulation of acid-sensing ion channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie]
comment: The reason for obsoletion is that this activity represents a gene family with GO:0160128 pH-gated channel activity.
synonym: "regulation of ASIC activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0099106

[Term]
id: GO:1901586
name: obsolete negative regulation of acid-sensing ion channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie]
comment: The reason for obsoletion is that this activity represents a gene family with GO:0160128 pH-gated channel activity.
synonym: "down regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acid-sensing ion channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ASIC activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ASIC activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0008200

[Term]
id: GO:1901587
name: obsolete positive regulation of acid-sensing ion channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie]
comment: The reason for obsoletion is that this activity represents a gene family with GO:0160128 pH-gated channel activity.
synonym: "activation of acid-sensing ion channel activity" NARROW [GOC:TermGenie]
synonym: "activation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ASIC activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0099103

[Term]
id: GO:1901588
name: dendritic microtubule
namespace: cellular_component
def: "Any microtubule in a dendrite, a neuron projection." [GOC:TermGenie, NIF_Subcellular:sao110773650]
synonym: "microtubule of dendrite" EXACT [GOC:TermGenie]
synonym: "microtubulus of dendrite" EXACT [GOC:TermGenie]
xref: NIF_Subcellular:sao110773650
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:1901589
name: axon microtubule bundle
namespace: cellular_component
def: "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment." [GOC:TermGenie, NIF_Subcellular:sao707332678]
synonym: "axon microtubule fascicle" EXACT []
synonym: "microtubule bundle of axon" EXACT [GOC:TermGenie]
synonym: "microtubule fascicle of axon" EXACT [GOC:TermGenie]
xref: NIF_Subcellular:sao707332678
is_a: GO:0097427 ! microtubule bundle
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:1901591
name: regulation of double-strand break repair via break-induced replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie]
is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination
relationship: regulates GO:0000727 ! double-strand break repair via break-induced replication

[Term]
id: GO:1901592
name: negative regulation of double-strand break repair via break-induced replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie]
synonym: "down regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie]
synonym: "downregulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie]
synonym: "inhibition of double-strand break repair via break-induced replication" NARROW [GOC:TermGenie]
is_a: GO:1901591 ! regulation of double-strand break repair via break-induced replication
is_a: GO:2000042 ! negative regulation of double-strand break repair via homologous recombination
relationship: negatively_regulates GO:0000727 ! double-strand break repair via break-induced replication

[Term]
id: GO:1901593
name: response to GW 7647
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:TermGenie]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901594
name: response to capsazepine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901595
name: response to hesperadin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0014075 ! response to amine
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901596
name: response to reversine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:TermGenie]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901597
name: response to carbendazim
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901598
name: (-)-pinoresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-pinoresinol." [GOC:TermGenie]
synonym: "(-)-pinoresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:1901599
name: (-)-pinoresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-pinoresinol." [GOC:TermGenie]
synonym: "(-)-pinoresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol formation" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901598 ! (-)-pinoresinol metabolic process

[Term]
id: GO:1901600
name: strigolactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving strigolactone." [GOC:TermGenie]
synonym: "strigolactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:1901601
name: strigolactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of strigolactone." [GOC:TermGenie]
synonym: "strigolactone anabolism" EXACT [GOC:TermGenie]
synonym: "strigolactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "strigolactone formation" EXACT [GOC:TermGenie]
synonym: "strigolactone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901600 ! strigolactone metabolic process

[Term]
id: GO:1901602
name: dethiobiotin binding
namespace: molecular_function
def: "Binding to dethiobiotin." [GOC:TermGenie]
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:1901604
name: dethiobiotin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of dethiobiotin from one side of a membrane to the other." [GOC:TermGenie]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:1901605
name: alpha-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:1901606
name: alpha-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:1901607
name: alpha-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:1901608
name: regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
relationship: regulates GO:0047496 ! vesicle transport along microtubule

[Term]
id: GO:1901609
name: negative regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
relationship: negatively_regulates GO:0047496 ! vesicle transport along microtubule

[Term]
id: GO:1901610
name: positive regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
relationship: positively_regulates GO:0047496 ! vesicle transport along microtubule

[Term]
id: GO:1901611
name: phosphatidylglycerol binding
namespace: molecular_function
def: "Binding to phosphatidylglycerol." [GOC:kmv, GOC:TermGenie]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:1901612
name: cardiolipin binding
namespace: molecular_function
def: "Binding to cardiolipin." [GOC:kmv, GOC:TermGenie]
is_a: GO:1901611 ! phosphatidylglycerol binding

[Term]
id: GO:1901613
name: negative regulation of terminal button organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000]
synonym: "down regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "downregulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "inhibition of bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal button organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal button organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal button organisation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:2000331 ! regulation of terminal button organization
relationship: negatively_regulates GO:0072553 ! terminal button organization

[Term]
id: GO:1901614
name: positive regulation of terminal button organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000]
synonym: "activation of bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of terminal bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of terminal button organisation" NARROW [GOC:TermGenie]
synonym: "activation of terminal button organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "upregulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal button organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:2000331 ! regulation of terminal button organization
relationship: positively_regulates GO:0072553 ! terminal button organization

[Term]
id: GO:1901615
name: organic hydroxy compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901616
name: organic hydroxy compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:1901617
name: organic hydroxy compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound formation" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:1901618
name: organic hydroxy compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901619
name: obsolete tRNA methylation in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule as a result of deprivation of nitrogen." [GOC:TermGenie, PMID:23074192]
is_obsolete: true

[Term]
id: GO:1901620
name: regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie]
synonym: "regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
is_a: GO:0008589 ! regulation of smoothened signaling pathway
relationship: regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning

[Term]
id: GO:1901621
name: negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie]
synonym: "down regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "inhibition of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "inhibition of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "inhibition of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "inhibition of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "negative regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "negative regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "negative regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
is_a: GO:0045879 ! negative regulation of smoothened signaling pathway
is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
relationship: negatively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning

[Term]
id: GO:1901622
name: positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie]
synonym: "activation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "activation of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "activation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "activation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "positive regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "positive regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "positive regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
is_a: GO:0045880 ! positive regulation of smoothened signaling pathway
is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
relationship: positively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning

[Term]
id: GO:1901623
name: regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:2000401 ! regulation of lymphocyte migration
relationship: regulates GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:1901624
name: negative regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie]
synonym: "down regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "inhibition of lymphocyte chemotaxis" NARROW [GOC:TermGenie]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000402 ! negative regulation of lymphocyte migration
relationship: negatively_regulates GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:1901625
name: cellular response to ergosterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus." [GOC:TermGenie]
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:0097306 ! cellular response to alcohol

[Term]
id: GO:1901626
name: regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "regulation of post-synaptic membrane organization" EXACT []
synonym: "regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:1901627
name: negative regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "down regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "inhibition of postsynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of postsynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of post-synaptic membrane organization" EXACT []
synonym: "negative regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
is_a: GO:1905809 ! negative regulation of synapse organization
relationship: negatively_regulates GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:1901628
name: positive regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "activation of postsynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "activation of postsynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of post-synaptic membrane organization" EXACT []
synonym: "positive regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
relationship: positively_regulates GO:0001941 ! postsynaptic membrane organization

[Term]
id: GO:1901629
name: regulation of presynaptic membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "regulation of pre-synaptic membrane organization" EXACT []
synonym: "regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0097090 ! presynaptic membrane organization

[Term]
id: GO:1901630
name: negative regulation of presynaptic membrane organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "down regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "inhibition of presynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of pre-synaptic membrane organization" EXACT []
synonym: "negative regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:1901629 ! regulation of presynaptic membrane organization
is_a: GO:1905809 ! negative regulation of synapse organization
relationship: negatively_regulates GO:0097090 ! presynaptic membrane organization

[Term]
id: GO:1901631
name: positive regulation of presynaptic membrane organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "activation of presynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of pre-synaptic membrane organization" EXACT []
synonym: "positive regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901629 ! regulation of presynaptic membrane organization
relationship: positively_regulates GO:0097090 ! presynaptic membrane organization

[Term]
id: GO:1901632
name: regulation of synaptic vesicle membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0048499 ! synaptic vesicle membrane organization

[Term]
id: GO:1901633
name: negative regulation of synaptic vesicle membrane organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "down regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle membrane organization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle membrane organization and biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization
relationship: negatively_regulates GO:0048499 ! synaptic vesicle membrane organization

[Term]
id: GO:1901634
name: positive regulation of synaptic vesicle membrane organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "activation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle membrane organization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization
relationship: positively_regulates GO:0048499 ! synaptic vesicle membrane organization

[Term]
id: GO:1901635
name: obsolete regulation of maintenance of presynaptic active zone structure
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PMID:22426000]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of maintenance of presynaptic active zone structure" EXACT []
is_obsolete: true

[Term]
id: GO:1901636
name: obsolete negative regulation of maintenance of presynaptic active zone structure
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PMID:22426000]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "inhibition of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of maintenance of presynaptic active zone structure" EXACT []
is_obsolete: true

[Term]
id: GO:1901637
name: obsolete positive regulation of maintenance of presynaptic active zone structure
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PMID:22426000]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of maintenance of presynaptic active zone structure" EXACT []
synonym: "up regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901638
name: obsolete copper ion import into ascospore-type prospore
namespace: biological_process
def: "OBSOLETE. Any copper ion import that takes place in ascospore-type prospore." [GOC:TermGenie]
comment: https://sourceforge.net/tracker/index.php?func=detail&aid=3510080&group_id=36855&atid=440764
synonym: "copper ion import into ascospore-type prospore" EXACT []
synonym: "copper ion uptake in ascospore-type prospore" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901639
name: obsolete XDP catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of XDP." [GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this reaction exist in vivo.
synonym: "XDP breakdown" EXACT [GOC:TermGenie]
synonym: "XDP catabolism" EXACT [GOC:TermGenie]
synonym: "XDP degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901640
name: XTP binding
namespace: molecular_function
def: "Binding to XTP." [GOC:TermGenie]
is_a: GO:0032555 ! purine ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding

[Term]
id: GO:1901641
name: ITP binding
namespace: molecular_function
def: "Binding to ITP." [GOC:TermGenie]
is_a: GO:0032555 ! purine ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding

[Term]
id: GO:1901642
name: nucleoside transmembrane transport
namespace: biological_process
def: "The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nucleoside membrane transport" EXACT []
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1901643
name: obsolete regulation of tRNA methylation in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901644
name: obsolete positive regulation of tRNA methylation in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie]
synonym: "activation of tRNA methylation in response to nitrogen starvation" NARROW [GOC:TermGenie]
synonym: "up regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901645
name: regulation of synoviocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0002941 ! synoviocyte proliferation

[Term]
id: GO:1901646
name: negative regulation of synoviocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie]
synonym: "down regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of synoviocyte proliferation" NARROW [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1901645 ! regulation of synoviocyte proliferation
relationship: negatively_regulates GO:0002941 ! synoviocyte proliferation

[Term]
id: GO:1901647
name: positive regulation of synoviocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie]
synonym: "activation of synoviocyte proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1901645 ! regulation of synoviocyte proliferation
relationship: positively_regulates GO:0002941 ! synoviocyte proliferation

[Term]
id: GO:1901648
name: obsolete regulation of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
synonym: "regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:2000073

[Term]
id: GO:1901649
name: obsolete negative regulation of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
is_obsolete: true
replaced_by: GO:2000075

[Term]
id: GO:1901650
name: obsolete positive regulation of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
is_obsolete: true
replaced_by: GO:2000076

[Term]
id: GO:1901651
name: obsolete regulation of mitotic chromosome decondensation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic chromosome decondensation." [GOC:TermGenie]
comment: This term was obsoleted because it is a spontaneous process.
is_obsolete: true

[Term]
id: GO:1901652
name: response to peptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1901653
name: cellular response to peptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901652 ! response to peptide

[Term]
id: GO:1901654
name: response to ketone
namespace: biological_process
alt_id: GO:1990369
def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676]
synonym: "process resulting in tolerance to ketone" NARROW []
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901655
name: cellular response to ketone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:1901654 ! response to ketone
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:1901656
name: glycoside transport
namespace: biological_process
def: "The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:1901657
name: glycosyl compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie]
synonym: "glycosyl compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:1901658
name: glycosyl compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]
synonym: "glycosyl compound breakdown" EXACT [GOC:TermGenie]
synonym: "glycosyl compound catabolism" EXACT [GOC:TermGenie]
synonym: "glycosyl compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:1901659
name: glycosyl compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosyl compound." [GOC:pr, GOC:TermGenie]
synonym: "glycosyl compound anabolism" EXACT [GOC:TermGenie]
synonym: "glycosyl compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "glycosyl compound formation" EXACT [GOC:TermGenie]
synonym: "glycosyl compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:1901660
name: calcium ion export
namespace: biological_process
def: "The directed movement of calcium ion out of a cell or organelle." [GOC:TermGenie]
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:1901661
name: quinone metabolic process
namespace: biological_process
alt_id: GO:0042375
def: "The chemical reactions and pathways involving quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie]
synonym: "quinone cofactor metabolic process" RELATED []
synonym: "quinone cofactor metabolism" RELATED []
synonym: "quinone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1901662
name: quinone catabolic process
namespace: biological_process
alt_id: GO:0042378
def: "The chemical reactions and pathways resulting in the breakdown of quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie]
synonym: "quinone breakdown" EXACT [GOC:TermGenie]
synonym: "quinone catabolism" EXACT [GOC:TermGenie]
synonym: "quinone cofactor breakdown" RELATED []
synonym: "quinone cofactor catabolic process" RELATED []
synonym: "quinone cofactor catabolism" RELATED []
synonym: "quinone cofactor degradation" RELATED []
synonym: "quinone degradation" EXACT [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901661 ! quinone metabolic process

[Term]
id: GO:1901663
name: quinone biosynthetic process
namespace: biological_process
alt_id: GO:0045426
def: "The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]
synonym: "quinone anabolism" EXACT [GOC:TermGenie]
synonym: "quinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "quinone cofactor anabolism" RELATED []
synonym: "quinone cofactor biosynthesis" RELATED []
synonym: "quinone cofactor biosynthetic process" RELATED []
synonym: "quinone cofactor formation" RELATED []
synonym: "quinone cofactor synthesis" RELATED []
synonym: "quinone formation" EXACT [GOC:TermGenie]
synonym: "quinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901661 ! quinone metabolic process

[Term]
id: GO:1901664
name: regulation of NAD+ ADP-ribosyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
is_a: GO:0010835 ! regulation of protein ADP-ribosylation

[Term]
id: GO:1901665
name: obsolete negative regulation of NAD+ ADP-ribosyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901666
name: positive regulation of NAD+ ADP-ribosyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "activation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "activation of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1901664 ! regulation of NAD+ ADP-ribosyltransferase activity

[Term]
id: GO:1901667
name: negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration." [GOC:dph, GOC:TermGenie, PMID:21272575]
synonym: "down regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of satellite cell activation involved in skeletal muscle regeneration" NARROW [GOC:TermGenie]
is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration
is_a: GO:0043417 ! negative regulation of skeletal muscle tissue regeneration
is_a: GO:0050866 ! negative regulation of cell activation
relationship: negatively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:1901668
name: regulation of superoxide dismutase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "regulation of SOD" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "regulation of SODF" RELATED [GOC:TermGenie]
synonym: "regulation of SODS" RELATED [GOC:TermGenie]
synonym: "regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1901670
name: negative regulation of superoxide dismutase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "down regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "down regulation of SODF" RELATED [GOC:TermGenie]
synonym: "down regulation of SODS" RELATED [GOC:TermGenie]
synonym: "down regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "down regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "down regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "down-regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "down-regulation of SODF" RELATED [GOC:TermGenie]
synonym: "down-regulation of SODS" RELATED [GOC:TermGenie]
synonym: "down-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "down-regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "down-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "downregulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "downregulation of SODF" RELATED [GOC:TermGenie]
synonym: "downregulation of SODS" RELATED [GOC:TermGenie]
synonym: "downregulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "downregulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "downregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of cytocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hemocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "inhibition of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-1" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-2" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-3" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-4" RELATED [GOC:TermGenie]
synonym: "inhibition of SODF" RELATED [GOC:TermGenie]
synonym: "inhibition of SODS" RELATED [GOC:TermGenie]
synonym: "inhibition of superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "inhibition of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "inhibition of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "negative regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "negative regulation of SODF" RELATED [GOC:TermGenie]
synonym: "negative regulation of SODS" RELATED [GOC:TermGenie]
synonym: "negative regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "negative regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "negative regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1901668 ! regulation of superoxide dismutase activity
is_a: GO:1904832 ! negative regulation of removal of superoxide radicals

[Term]
id: GO:1901671
name: positive regulation of superoxide dismutase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "activation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of cuprein" RELATED [GOC:TermGenie]
synonym: "activation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "activation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "activation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "activation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "activation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "activation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "activation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "activation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "activation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "activation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "activation of SOD" RELATED [GOC:TermGenie]
synonym: "activation of SOD-1" RELATED [GOC:TermGenie]
synonym: "activation of SOD-2" RELATED [GOC:TermGenie]
synonym: "activation of SOD-3" RELATED [GOC:TermGenie]
synonym: "activation of SOD-4" RELATED [GOC:TermGenie]
synonym: "activation of SODF" RELATED [GOC:TermGenie]
synonym: "activation of SODS" RELATED [GOC:TermGenie]
synonym: "activation of superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "activation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "activation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "activation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "positive regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "positive regulation of SODF" RELATED [GOC:TermGenie]
synonym: "positive regulation of SODS" RELATED [GOC:TermGenie]
synonym: "positive regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "positive regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "positive regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "up regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "up regulation of SODF" RELATED [GOC:TermGenie]
synonym: "up regulation of SODS" RELATED [GOC:TermGenie]
synonym: "up regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "up regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "up regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "up-regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "up-regulation of SODF" RELATED [GOC:TermGenie]
synonym: "up-regulation of SODS" RELATED [GOC:TermGenie]
synonym: "up-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "up-regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "up-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "upregulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "upregulation of SODF" RELATED [GOC:TermGenie]
synonym: "upregulation of SODS" RELATED [GOC:TermGenie]
synonym: "upregulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "upregulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "upregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1901668 ! regulation of superoxide dismutase activity

[Term]
id: GO:1901672
name: positive regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of systemic acquired resistance." [GOC:TermGenie]
synonym: "activation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "activation of systemic acquired resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "up regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "up regulation of systemic acquired resistance" EXACT [GOC:TermGenie]
synonym: "up-regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "up-regulation of systemic acquired resistance" EXACT [GOC:TermGenie]
synonym: "upregulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "upregulation of systemic acquired resistance" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
relationship: positively_regulates GO:0009627 ! systemic acquired resistance

[Term]
id: GO:1901673
name: regulation of mitotic spindle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]
synonym: "regulation of spindle assembly involved in mitosis" EXACT []
is_a: GO:0060236 ! regulation of mitotic spindle organization
is_a: GO:0090169 ! regulation of spindle assembly
relationship: regulates GO:0090307 ! mitotic spindle assembly

[Term]
id: GO:1901674
name: obsolete regulation of histone H3-K27 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0031507
consider: GO:0045815

[Term]
id: GO:1901675
name: obsolete negative regulation of histone H3-K27 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K27 acetylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0031507

[Term]
id: GO:1901676
name: obsolete positive regulation of histone H3-K27 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "activation of histone H3-K27 acetylation" NARROW [GOC:TermGenie]
synonym: "activation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0045815

[Term]
id: GO:1901678
name: iron coordination entity transport
namespace: biological_process
def: "The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0006826 ! iron ion transport

[Term]
id: GO:1901679
name: nucleotide transmembrane transport
namespace: biological_process
def: "The directed movement of nucleotide across a membrane." [GOC:pr, GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nucleotide membrane transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1901680
name: obsolete sulfur-containing amino acid secondary active transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted because it does not define a specific transport mechanism.
is_obsolete: true

[Term]
id: GO:1901681
name: sulfur compound binding
namespace: molecular_function
def: "Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]
synonym: "sulfur molecular entity binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:1901682
name: sulfur compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "sulfur molecular entity transmembrane transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901683
name: arsenate ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an arsenate ion from one side of a membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901684
name: arsenate ion transmembrane transport
namespace: biological_process
def: "The process in which arsenate is transported across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
is_a: GO:0015700 ! arsenite transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1901685
name: glutathione derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutathione derivative." [GOC:pr, GOC:TermGenie]
synonym: "glutathione derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:1901686
name: glutathione derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutathione derivative." [GOC:pr, GOC:TermGenie]
synonym: "glutathione derivative breakdown" EXACT [GOC:TermGenie]
synonym: "glutathione derivative catabolism" EXACT [GOC:TermGenie]
synonym: "glutathione derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901685 ! glutathione derivative metabolic process

[Term]
id: GO:1901687
name: glutathione derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutathione derivative." [GOC:pr, GOC:TermGenie]
synonym: "glutathione derivative anabolism" EXACT [GOC:TermGenie]
synonym: "glutathione derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "glutathione derivative formation" EXACT [GOC:TermGenie]
synonym: "glutathione derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901685 ! glutathione derivative metabolic process

[Term]
id: GO:1901691
name: proton binding
namespace: molecular_function
def: "Binding to proton." [GOC:TermGenie]
synonym: "hydrogen ion binding" EXACT [GOC:bm]
is_a: GO:0043169 ! cation binding

[Term]
id: GO:1901692
name: regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:1990010 ! compound eye retinal cell apoptotic process

[Term]
id: GO:1901693
name: negative regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
relationship: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process

[Term]
id: GO:1901694
name: positive regulation of compound eye retinal cell apoptotic process
namespace: biological_process
alt_id: GO:0046675
def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "induction of compound eye retinal cell programmed cell death" RELATED []
synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
relationship: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process

[Term]
id: GO:1901695
name: tyramine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyramine." [GOC:TermGenie, PMID:21284755]
synonym: "tyramine anabolism" EXACT [GOC:TermGenie]
synonym: "tyramine biosynthesis" EXACT [GOC:TermGenie]
synonym: "tyramine formation" EXACT [GOC:TermGenie]
synonym: "tyramine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:1901696
name: cannabinoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cannabinoid." [GOC:TermGenie]
synonym: "cannabinoid anabolism" EXACT [GOC:TermGenie]
synonym: "cannabinoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "cannabinoid formation" EXACT [GOC:TermGenie]
synonym: "cannabinoid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:1901697
name: olivetolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of olivetolic acid." [GOC:TermGenie]
synonym: "olivetolic acid anabolism" EXACT [GOC:TermGenie]
synonym: "olivetolic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "olivetolic acid formation" EXACT [GOC:TermGenie]
synonym: "olivetolic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:1901698
name: response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to nitrogen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1901699
name: cellular response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cellular response to nitrogen molecular entity" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1901700
name: response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to oxygen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1901701
name: cellular response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "cellular response to oxygen molecular entity" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1901702
name: salt transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1901703
name: protein localization involved in auxin polar transport
namespace: biological_process
def: "Any protein localization that is involved in auxin polar transport." [GOC:TermGenie, PMID:23163883]
synonym: "establishment and maintenance of protein localization involved in auxin polar transport" EXACT [GOC:TermGenie]
synonym: "protein localisation involved in auxin polar transport" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
relationship: part_of GO:0009926 ! auxin polar transport

[Term]
id: GO:1901704
name: L-glutamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-glutamine." [GOC:TermGenie]
synonym: "L-glutamine anabolism" EXACT [GOC:TermGenie]
synonym: "L-glutamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "L-glutamine formation" EXACT [GOC:TermGenie]
synonym: "L-glutamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006542 ! glutamine biosynthetic process

[Term]
id: GO:1901705
name: L-isoleucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-isoleucine." [GOC:TermGenie]
synonym: "L-isoleucine anabolism" EXACT [GOC:TermGenie]
synonym: "L-isoleucine biosynthesis" EXACT [GOC:TermGenie]
synonym: "L-isoleucine formation" EXACT [GOC:TermGenie]
synonym: "L-isoleucine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0009097 ! isoleucine biosynthetic process

[Term]
id: GO:1901706
name: mesenchymal cell differentiation involved in bone development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217]
is_a: GO:0048762 ! mesenchymal cell differentiation
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:1901707
name: leptomycin B binding
namespace: molecular_function
def: "Binding to leptomycin B." [GOC:TermGenie]
is_a: GO:0005504 ! fatty acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:1901708
name: (+)-3'-hydroxylarreatricin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-3'-hydroxylarreatricin." [GOC:TermGenie, PMID:12960376]
synonym: "(+)-3'-hydroxylarreatricin anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-3'-hydroxylarreatricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-3'-hydroxylarreatricin formation" EXACT [GOC:TermGenie]
synonym: "(+)-3'-hydroxylarreatricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process

[Term]
id: GO:1901709
name: (+)-larreatricin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-larreatricin." [GOC:TermGenie, PMID:12960376]
synonym: "(+)-larreatricin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:1901710
name: regulation of homoserine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie]
synonym: "regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "regulation of homoserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0009090 ! homoserine biosynthetic process

[Term]
id: GO:1901711
name: negative regulation of homoserine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of homoserine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901710 ! regulation of homoserine biosynthetic process
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:0009090 ! homoserine biosynthetic process

[Term]
id: GO:1901712
name: positive regulation of homoserine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie]
synonym: "activation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of homoserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "activation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1901710 ! regulation of homoserine biosynthetic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
relationship: positively_regulates GO:0009090 ! homoserine biosynthetic process

[Term]
id: GO:1901713
name: negative regulation of urea catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process." [GOC:TermGenie]
synonym: "down regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "down regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "downregulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of urea breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of urea catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of urea catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of urea decomposition" EXACT [GOC:TermGenie]
synonym: "inhibition of urea degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea degradation" EXACT [GOC:TermGenie]
is_a: GO:0034252 ! negative regulation of amide catabolic process
is_a: GO:0034254 ! regulation of urea catabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1903315 ! negative regulation of nitrogen cycle metabolic process
relationship: negatively_regulates GO:0043419 ! urea catabolic process

[Term]
id: GO:1901714
name: positive regulation of urea catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of urea catabolic process." [GOC:TermGenie]
synonym: "activation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "activation of urea catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "activation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "activation of urea degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "up regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "upregulation of urea degradation" EXACT [GOC:TermGenie]
is_a: GO:0034253 ! positive regulation of amide catabolic process
is_a: GO:0034254 ! regulation of urea catabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1903316 ! positive regulation of nitrogen cycle metabolic process
relationship: positively_regulates GO:0043419 ! urea catabolic process

[Term]
id: GO:1901715
name: regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0009450 ! gamma-aminobutyric acid catabolic process

[Term]
id: GO:1901716
name: negative regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "down regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process
relationship: negatively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process

[Term]
id: GO:1901717
name: positive regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "activation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process
relationship: positively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process

[Term]
id: GO:1901718
name: obsolete regulation of dipeptide transmembrane transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of dipeptide transmembrane transport." [GOC:TermGenie, GOC:vw]
comment: The term was obsoleted because it is better represented by a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1901722
name: regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0072111 ! cell proliferation involved in kidney development

[Term]
id: GO:1901723
name: negative regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
synonym: "down regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "inhibition of cell proliferation involved in kidney development" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
relationship: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development

[Term]
id: GO:1901724
name: positive regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
synonym: "activation of cell proliferation involved in kidney development" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
relationship: positively_regulates GO:0072111 ! cell proliferation involved in kidney development

[Term]
id: GO:1901725
name: obsolete regulation of histone deacetylase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1901726
name: obsolete negative regulation of histone deacetylase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of histone deacetylase activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901727
name: obsolete positive regulation of histone deacetylase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone deacetylase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deacetylase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901728
name: monensin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]
synonym: "monensin A metabolism" EXACT [GOC:TermGenie]
synonym: "monensin metabolism" EXACT [GOC:yaf]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:1901729
name: monensin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]
synonym: "monensin A breakdown" EXACT [GOC:TermGenie]
synonym: "monensin A catabolism" EXACT [GOC:TermGenie]
synonym: "monensin A degradation" EXACT [GOC:TermGenie]
synonym: "monensin breakdown" EXACT [GOC:yaf]
synonym: "monensin catabolism" EXACT [GOC:yaf]
synonym: "monensin degradation" EXACT [GOC:yaf]
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901728 ! monensin A metabolic process

[Term]
id: GO:1901730
name: monensin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]
synonym: "monensin A anabolism" EXACT [GOC:TermGenie]
synonym: "monensin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "monensin A formation" EXACT [GOC:TermGenie]
synonym: "monensin A synthesis" EXACT [GOC:TermGenie]
synonym: "monensin anabolism" EXACT [GOC:yaf]
synonym: "monensin biosynthesis" EXACT [GOC:yaf]
synonym: "monensin formation" EXACT [GOC:yaf]
synonym: "monensin synthesis" EXACT [GOC:yaf]
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901728 ! monensin A metabolic process

[Term]
id: GO:1901731
name: positive regulation of platelet aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:fj, GOC:TermGenie]
synonym: "activation of blood platelet aggregation" NARROW [GOC:TermGenie]
synonym: "activation of platelet aggregation" NARROW [GOC:TermGenie]
synonym: "activation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "positive regulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "positive regulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "up regulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "upregulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of platelet aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:0090330 ! regulation of platelet aggregation
relationship: positively_regulates GO:0070527 ! platelet aggregation

[Term]
id: GO:1901732
name: quercetin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]
synonym: "quercetin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:1901733
name: quercetin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]
synonym: "quercetin breakdown" EXACT [GOC:TermGenie]
synonym: "quercetin catabolism" EXACT [GOC:TermGenie]
synonym: "quercetin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1901732 ! quercetin metabolic process

[Term]
id: GO:1901734
name: quercetin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]
synonym: "quercetin anabolism" EXACT [GOC:TermGenie]
synonym: "quercetin biosynthesis" EXACT [GOC:TermGenie]
synonym: "quercetin formation" EXACT [GOC:TermGenie]
synonym: "quercetin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1901732 ! quercetin metabolic process

[Term]
id: GO:1901735
name: (R)-mevalonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]
synonym: "(R) mevalonate metabolism" EXACT [GOC:yaf]
synonym: "(R)-mevalonic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:1901736
name: (R)-mevalonic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]
synonym: "(R)-mevalonate breakdown" EXACT [MetaCyc:PWY-5074]
synonym: "(R)-mevalonate catabolism" EXACT [MetaCyc:PWY-5074]
synonym: "(R)-mevalonate degradation" EXACT [MetaCyc:PWY-5074]
synonym: "(R)-mevalonic acid breakdown" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid catabolism" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1901735 ! (R)-mevalonic acid metabolic process

[Term]
id: GO:1901737
name: (R)-mevalonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]
synonym: "(R)-mevalonate anabolism" EXACT [GOC:yaf]
synonym: "(R)-mevalonate biosynthesis" EXACT [GOC:yaf]
synonym: "(R)-mevalonate synthesis" EXACT [GOC:yaf]
synonym: "(R)-mevalonic acid anabolism" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid formation" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1901735 ! (R)-mevalonic acid metabolic process

[Term]
id: GO:1901738
name: regulation of vitamin A metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitamin A metabolic process." [GOC:TermGenie, PMID:18093975]
synonym: "regulation of vitamin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
relationship: regulates GO:0006776 ! vitamin A metabolic process

[Term]
id: GO:1901739
name: regulation of myoblast fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: regulates GO:0007520 ! myoblast fusion

[Term]
id: GO:1901740
name: negative regulation of myoblast fusion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
synonym: "down regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "inhibition of myoblast fusion" NARROW [GOC:TermGenie]
is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion
is_a: GO:1901739 ! regulation of myoblast fusion
relationship: negatively_regulates GO:0007520 ! myoblast fusion

[Term]
id: GO:1901741
name: positive regulation of myoblast fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
synonym: "activation of myoblast fusion" NARROW [GOC:TermGenie]
synonym: "up regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of myoblast fusion" EXACT [GOC:TermGenie]
is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion
is_a: GO:1901739 ! regulation of myoblast fusion
relationship: positively_regulates GO:0007520 ! myoblast fusion

[Term]
id: GO:1901742
name: 2-deoxystreptamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf]
synonym: "2-deoxystreptamine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:1901743
name: 2-deoxystreptamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf]
synonym: "2-deoxystreptamine breakdown" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine catabolism" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine degradation" EXACT [GOC:TermGenie]
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901742 ! 2-deoxystreptamine metabolic process

[Term]
id: GO:1901744
name: 2-deoxystreptamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00907]
synonym: "2-deoxystreptamine anabolism" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine formation" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901742 ! 2-deoxystreptamine metabolic process

[Term]
id: GO:1901745
name: prephenate(2-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890]
synonym: "prephenate metabolism" EXACT [GOC:yaf]
synonym: "prephenate(2-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:1901746
name: prephenate(2-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890]
synonym: "prephenate breakdown" EXACT [GOC:yaf]
synonym: "prephenate catabolism" EXACT [GOC:yaf]
synonym: "prephenate degradation" EXACT [GOC:yaf]
synonym: "prephenate(2-) breakdown" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) catabolism" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:1901745 ! prephenate(2-) metabolic process

[Term]
id: GO:1901747
name: prephenate(2-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890, UniPathway:UPA00120]
synonym: "prephenate anabolism" EXACT [GOC:yaf]
synonym: "prephenate biosynthesis" EXACT [GOC:yaf]
synonym: "prephenate formation" EXACT [GOC:yaf]
synonym: "prephenate synthesis" EXACT [GOC:yaf]
synonym: "prephenate(2-) anabolism" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) formation" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:1901745 ! prephenate(2-) metabolic process

[Term]
id: GO:1901748
name: leukotriene D4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene D4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene D4 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:1901749
name: leukotriene D4 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leukotriene D4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene D4 breakdown" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 catabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 degradation" EXACT [GOC:TermGenie]
is_a: GO:0036100 ! leukotriene catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901523 ! icosanoid catabolic process
is_a: GO:1901748 ! leukotriene D4 metabolic process

[Term]
id: GO:1901750
name: leukotriene D4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene D4." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00880]
synonym: "leukotriene D4 anabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 biosynthesis" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 formation" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019370 ! leukotriene biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
is_a: GO:1901748 ! leukotriene D4 metabolic process

[Term]
id: GO:1901751
name: leukotriene A4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene A4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene A4 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:1901752
name: leukotriene A4 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leukotriene A4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene A4 breakdown" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 catabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 degradation" EXACT [GOC:TermGenie]
is_a: GO:0036100 ! leukotriene catabolic process
is_a: GO:0042758 ! long-chain fatty acid catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901523 ! icosanoid catabolic process
is_a: GO:1901751 ! leukotriene A4 metabolic process

[Term]
id: GO:1901753
name: leukotriene A4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene A4." [GOC:TermGenie, GOC:yaf, PMID:23242647]
synonym: "eoxin A4 biosynthesis" EXACT []
synonym: "leukotriene A4 anabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 biosynthesis" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 formation" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 synthesis" EXACT [GOC:TermGenie]
synonym: "LTA4 biosynthesis" EXACT []
is_a: GO:0019370 ! leukotriene biosynthetic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
is_a: GO:1901751 ! leukotriene A4 metabolic process

[Term]
id: GO:1901754
name: vitamin D3 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vitamin D3." [GOC:TermGenie, GOC:yaf]
synonym: "calciol breakdown" EXACT [GOC:TermGenie]
synonym: "calciol catabolic process" EXACT [GOC:pr]
synonym: "calciol catabolism" EXACT [GOC:TermGenie]
synonym: "calciol degradation" EXACT [GOC:TermGenie]
synonym: "cholecalciferol catabolic process" EXACT [GOC:pr]
synonym: "cholecalciferol catabolism" EXACT [GOC:pr]
synonym: "vitamin D3 breakdown" EXACT [GOC:yaf]
synonym: "vitamin D3 catabolism" EXACT [GOC:yaf]
synonym: "vitamin D3 degradation" EXACT [GOC:yaf]
is_a: GO:0042369 ! vitamin D catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0070640 ! vitamin D3 metabolic process

[Term]
id: GO:1901755
name: vitamin D3 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin D3." [GOC:TermGenie, GOC:yaf, Unipathway:UPA00955]
synonym: "calciol anabolism" EXACT [GOC:TermGenie]
synonym: "calciol biosynthesis" EXACT [GOC:TermGenie]
synonym: "calciol biosynthetic process" EXACT [GOC:pr]
synonym: "calciol formation" EXACT [GOC:TermGenie]
synonym: "calciol synthesis" EXACT [GOC:TermGenie]
synonym: "cholecalciferol biosynthesis" EXACT [GOC:pr]
synonym: "cholecalciferol biosynthetic process" EXACT [GOC:pr]
synonym: "vitamin D3 anabolism" EXACT [GOC:yaf]
synonym: "vitamin D3 biosynthesis" EXACT [GOC:yaf]
synonym: "vitamin D3 formation" EXACT [GOC:yaf]
synonym: "vitamin D3 synthesis" EXACT [GOC:yaf]
is_a: GO:0042368 ! vitamin D biosynthetic process
is_a: GO:0070640 ! vitamin D3 metabolic process
is_a: GO:0120178 ! steroid hormone biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:1901756
name: butirosin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving butirosin." [GOC:TermGenie, GOC:yaf]
synonym: "butirosin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:1901757
name: butirosin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of butirosin." [GOC:TermGenie, GOC:yaf]
synonym: "butirosin breakdown" EXACT [GOC:TermGenie]
synonym: "butirosin catabolism" EXACT [GOC:TermGenie]
synonym: "butirosin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901756 ! butirosin metabolic process

[Term]
id: GO:1901758
name: butirosin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of butirosin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00964]
synonym: "butirosin anabolism" EXACT [GOC:TermGenie]
synonym: "butirosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "butirosin formation" EXACT [GOC:TermGenie]
synonym: "butirosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901756 ! butirosin metabolic process

[Term]
id: GO:1901759
name: beta-L-Ara4N-lipid A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-L-Ara4N-lipid A." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326]
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolic process" EXACT []
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolism" EXACT []
synonym: "beta-L-Ara4N-lipid A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process

[Term]
id: GO:1901760
name: beta-L-Ara4N-lipid A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-L-Ara4N-lipid A which occurs as a result of modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose (L-Ara4N). This strategy is adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326, UniPathway:UPA00037]
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis" EXACT []
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthetic process" EXACT []
synonym: "beta-L-Ara4N-lipid A anabolism" EXACT [GOC:TermGenie]
synonym: "beta-L-Ara4N-lipid A biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-L-Ara4N-lipid A formation" EXACT [GOC:TermGenie]
synonym: "beta-L-Ara4N-lipid A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:1901271 ! lipooligosaccharide biosynthetic process
is_a: GO:1901759 ! beta-L-Ara4N-lipid A metabolic process

[Term]
id: GO:1901761
name: oxytetracycline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168]
synonym: "oxytetracycline metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process

[Term]
id: GO:1901762
name: oxytetracycline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168]
synonym: "oxytetracycline breakdown" EXACT [GOC:TermGenie]
synonym: "oxytetracycline catabolism" EXACT [GOC:TermGenie]
synonym: "oxytetracycline degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1901761 ! oxytetracycline metabolic process

[Term]
id: GO:1901763
name: oxytetracycline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168, UniPathway:UPA00926]
synonym: "oxytetracycline anabolism" EXACT [GOC:TermGenie]
synonym: "oxytetracycline biosynthesis" EXACT [GOC:TermGenie]
synonym: "oxytetracycline formation" EXACT [GOC:TermGenie]
synonym: "oxytetracycline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:1901761 ! oxytetracycline metabolic process

[Term]
id: GO:1901764
name: phosphinothricin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphinothricin." [GOC:TermGenie, GOC:yaf]
synonym: "phosphinothricin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901765
name: phosphinothricin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphinothricin." [GOC:TermGenie, GOC:yaf]
synonym: "phosphinothricin breakdown" EXACT [GOC:TermGenie]
synonym: "phosphinothricin catabolism" EXACT [GOC:TermGenie]
synonym: "phosphinothricin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901764 ! phosphinothricin metabolic process

[Term]
id: GO:1901766
name: phosphinothricin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphinothricin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00168]
synonym: "phosphinothricin anabolism" EXACT [GOC:TermGenie]
synonym: "phosphinothricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "phosphinothricin formation" EXACT [GOC:TermGenie]
synonym: "phosphinothricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901764 ! phosphinothricin metabolic process

[Term]
id: GO:1901767
name: carbapenem metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024]
synonym: "carbapenem metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process

[Term]
id: GO:1901768
name: carbapenem catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024]
synonym: "carbapenem breakdown" EXACT [GOC:TermGenie]
synonym: "carbapenem catabolism" EXACT [GOC:TermGenie]
synonym: "carbapenem degradation" EXACT [GOC:TermGenie]
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:1901767 ! carbapenem metabolic process

[Term]
id: GO:1901769
name: carbapenem biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024, UniPathway:UPA00182]
synonym: "carbapenem anabolism" EXACT [GOC:TermGenie]
synonym: "carbapenem biosynthesis" EXACT [GOC:TermGenie]
synonym: "carbapenem formation" EXACT [GOC:TermGenie]
synonym: "carbapenem synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:1901767 ! carbapenem metabolic process

[Term]
id: GO:1901770
name: daunorubicin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857]
synonym: "daunorubicin breakdown" EXACT [GOC:TermGenie]
synonym: "daunorubicin catabolism" EXACT [GOC:TermGenie]
synonym: "daunorubicin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0044597 ! daunorubicin metabolic process

[Term]
id: GO:1901771
name: daunorubicin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857, UniPathway:UPA00054]
synonym: "daunorubicin anabolism" EXACT [GOC:TermGenie]
synonym: "daunorubicin biosynthesis" EXACT [GOC:TermGenie]
synonym: "daunorubicin formation" EXACT [GOC:TermGenie]
synonym: "daunorubicin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044597 ! daunorubicin metabolic process

[Term]
id: GO:1901772
name: lincomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249]
synonym: "lincomycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:1901773
name: lincomycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249]
synonym: "lincomycin breakdown" EXACT [GOC:TermGenie]
synonym: "lincomycin catabolism" EXACT [GOC:TermGenie]
synonym: "lincomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016145 ! S-glycoside catabolic process
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:1901772 ! lincomycin metabolic process

[Term]
id: GO:1901774
name: lincomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lincomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6955, PMID:8577249, UniPathway:UPA00161]
synonym: "lincomycin anabolism" EXACT [GOC:TermGenie]
synonym: "lincomycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "lincomycin formation" EXACT [GOC:TermGenie]
synonym: "lincomycin synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-6955
is_a: GO:0016144 ! S-glycoside biosynthetic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901772 ! lincomycin metabolic process

[Term]
id: GO:1901775
name: mitomycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135]
synonym: "mitomycin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1901776
name: mitomycin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135]
synonym: "mitomycin C breakdown" EXACT [GOC:TermGenie]
synonym: "mitomycin C catabolism" EXACT [GOC:TermGenie]
synonym: "mitomycin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901775 ! mitomycin C metabolic process

[Term]
id: GO:1901777
name: mitomycin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135, UniPathway:UPA00851]
synonym: "mitomycin C anabolism" EXACT [GOC:TermGenie]
synonym: "mitomycin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "mitomycin C formation" EXACT [GOC:TermGenie]
synonym: "mitomycin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901775 ! mitomycin C metabolic process

[Term]
id: GO:1901778
name: pentalenolactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094]
synonym: "pentalenolactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:1901779
name: pentalenolactone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094]
synonym: "pentalenolactone breakdown" EXACT [GOC:TermGenie]
synonym: "pentalenolactone catabolism" EXACT [GOC:TermGenie]
synonym: "pentalenolactone degradation" EXACT [GOC:TermGenie]
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901335 ! lactone catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901778 ! pentalenolactone metabolic process

[Term]
id: GO:1901780
name: pentalenolactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentalenolactone." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6915, PMID:17178094, UniPathway:UPA00974]
synonym: "pentalenolactone anabolism" EXACT [GOC:TermGenie]
synonym: "pentalenolactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "pentalenolactone formation" EXACT [GOC:TermGenie]
synonym: "pentalenolactone synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-6915
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901778 ! pentalenolactone metabolic process

[Term]
id: GO:1901781
name: p-cumate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713]
synonym: "p-cumate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:1901782
name: p-cumate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-cumate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5273, PMID:8631713, UniPathway:UPA00937]
synonym: "p-cumate breakdown" EXACT [GOC:TermGenie]
synonym: "p-cumate catabolism" EXACT [GOC:TermGenie]
synonym: "p-cumate degradation" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-5273
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901781 ! p-cumate metabolic process

[Term]
id: GO:1901783
name: p-cumate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713]
synonym: "p-cumate anabolism" EXACT [GOC:TermGenie]
synonym: "p-cumate biosynthesis" EXACT [GOC:TermGenie]
synonym: "p-cumate formation" EXACT [GOC:TermGenie]
synonym: "p-cumate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901781 ! p-cumate metabolic process

[Term]
id: GO:1901784
name: p-cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531]
synonym: "p-cresol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042212 ! cresol metabolic process

[Term]
id: GO:1901785
name: p-cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531, UniPathway:UPA00708]
synonym: "p-cresol breakdown" EXACT [GOC:TermGenie]
synonym: "p-cresol catabolism" EXACT [GOC:TermGenie]
synonym: "p-cresol degradation" EXACT [GOC:TermGenie]
is_a: GO:0046199 ! cresol catabolic process
is_a: GO:1901784 ! p-cresol metabolic process

[Term]
id: GO:1901786
name: p-cresol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531]
synonym: "p-cresol anabolism" EXACT [GOC:TermGenie]
synonym: "p-cresol biosynthesis" EXACT [GOC:TermGenie]
synonym: "p-cresol formation" EXACT [GOC:TermGenie]
synonym: "p-cresol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901784 ! p-cresol metabolic process

[Term]
id: GO:1901787
name: benzoyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoyl-CoA." [GOC:TermGenie, GOC:yaf]
synonym: "benzoyl-CoA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006637 ! acyl-CoA metabolic process

[Term]
id: GO:1901788
name: benzoyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA." [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361, UniPathway:UPA00739]
synonym: "benzoyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process
is_a: GO:1901787 ! benzoyl-CoA metabolic process

[Term]
id: GO:1901789
name: benzoyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzoyl-CoA." [GOC:TermGenie, GOC:yaf]
synonym: "benzoyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071616 ! acyl-CoA biosynthetic process
is_a: GO:1901787 ! benzoyl-CoA metabolic process

[Term]
id: GO:1901790
name: 3-(2,3-dihydroxyphenyl)propanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf]
synonym: "3-(2,3-dihydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:1901791
name: 3-(2,3-dihydroxyphenyl)propanoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:HCAMHPDEG-PWY, UniPathway:UPA00836]
synonym: "3-(2,3-dihydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process

[Term]
id: GO:1901792
name: 3-(2,3-dihydroxyphenyl)propanoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf]
synonym: "3-(2,3-dihydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process

[Term]
id: GO:1901793
name: 3-(3-hydroxyphenyl)propanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203]
synonym: "3-(3-hydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:1901794
name: 3-(3-hydroxyphenyl)propanoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY0-1277, PMID:10537203, UniPathway:UPA00835]
synonym: "3-(3-hydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie]
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process

[Term]
id: GO:1901795
name: 3-(3-hydroxyphenyl)propanoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203]
synonym: "3-(3-hydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process

[Term]
id: GO:1901796
name: regulation of signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0072331 ! signal transduction by p53 class mediator

[Term]
id: GO:1901797
name: negative regulation of signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]
synonym: "down regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0072331 ! signal transduction by p53 class mediator

[Term]
id: GO:1901798
name: positive regulation of signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]
synonym: "activation of signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "up regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0072331 ! signal transduction by p53 class mediator

[Term]
id: GO:1901799
name: negative regulation of proteasomal protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]
synonym: "down regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
is_a: GO:1903051 ! negative regulation of proteolysis involved in protein catabolic process
relationship: negatively_regulates GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:1901800
name: positive regulation of proteasomal protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]
synonym: "activation of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
is_a: GO:1903052 ! positive regulation of proteolysis involved in protein catabolic process
relationship: positively_regulates GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:1901801
name: 1,5-anhydro-D-fructose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]
synonym: "1,5-anhydro-D-fructose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0097176 ! epoxide metabolic process

[Term]
id: GO:1901802
name: 1,5-anhydro-D-fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]
synonym: "1,5-anhydro-D-fructose breakdown" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose catabolism" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose degradation" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-6992
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process

[Term]
id: GO:1901803
name: 1,5-anhydro-D-fructose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]
synonym: "1,5-anhydro-D-fructose anabolism" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose biosynthesis" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose formation" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process

[Term]
id: GO:1901804
name: beta-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]
synonym: "beta-glucoside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:1901805
name: beta-glucoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]
synonym: "beta-glucoside breakdown" EXACT [GOC:TermGenie]
synonym: "beta-glucoside catabolism" EXACT [GOC:TermGenie]
synonym: "beta-glucoside degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:1901806
name: beta-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]
synonym: "beta-glucoside anabolism" EXACT [GOC:TermGenie]
synonym: "beta-glucoside biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-glucoside formation" EXACT [GOC:TermGenie]
synonym: "beta-glucoside synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:1901807
name: capsanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving capsanthin." [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806]
synonym: "capsanthin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:1901808
name: capsanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of capsanthin." [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806]
synonym: "capsanthin breakdown" EXACT [GOC:TermGenie]
synonym: "capsanthin catabolism" EXACT [GOC:TermGenie]
synonym: "capsanthin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901807 ! capsanthin metabolic process

[Term]
id: GO:1901809
name: capsanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]
synonym: "capsanthin anabolism" EXACT [GOC:TermGenie]
synonym: "capsanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "capsanthin formation" EXACT [GOC:TermGenie]
synonym: "capsanthin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901807 ! capsanthin metabolic process

[Term]
id: GO:1901810
name: beta-carotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]
synonym: "beta-carotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0016119 ! carotene metabolic process

[Term]
id: GO:1901811
name: beta-carotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]
synonym: "beta-carotene breakdown" EXACT [GOC:TermGenie]
synonym: "beta-carotene catabolism" EXACT [GOC:TermGenie]
synonym: "beta-carotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901810 ! beta-carotene metabolic process

[Term]
id: GO:1901812
name: beta-carotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]
synonym: "beta-carotene anabolism" EXACT [GOC:TermGenie]
synonym: "beta-carotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-carotene formation" EXACT [GOC:TermGenie]
synonym: "beta-carotene synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-5943
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901810 ! beta-carotene metabolic process

[Term]
id: GO:1901813
name: astaxanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]
synonym: "astaxanthin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:1901814
name: astaxanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]
synonym: "astaxanthin breakdown" EXACT [GOC:TermGenie]
synonym: "astaxanthin catabolism" EXACT [GOC:TermGenie]
synonym: "astaxanthin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901813 ! astaxanthin metabolic process

[Term]
id: GO:1901815
name: astaxanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]
synonym: "astaxanthin anabolism" EXACT [GOC:TermGenie]
synonym: "astaxanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "astaxanthin formation" EXACT [GOC:TermGenie]
synonym: "astaxanthin synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-5288
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901813 ! astaxanthin metabolic process

[Term]
id: GO:1901816
name: beta-zeacarotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]
synonym: "beta-zeacarotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0016119 ! carotene metabolic process

[Term]
id: GO:1901817
name: beta-zeacarotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]
synonym: "beta-zeacarotene breakdown" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene catabolism" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901816 ! beta-zeacarotene metabolic process

[Term]
id: GO:1901818
name: beta-zeacarotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]
synonym: "beta-zeacarotene anabolism" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene formation" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901816 ! beta-zeacarotene metabolic process

[Term]
id: GO:1901819
name: alpha-zeacarotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]
synonym: "alpha-zeacarotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0016119 ! carotene metabolic process

[Term]
id: GO:1901820
name: alpha-zeacarotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]
synonym: "alpha-zeacarotene breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901819 ! alpha-zeacarotene metabolic process

[Term]
id: GO:1901821
name: alpha-zeacarotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]
synonym: "alpha-zeacarotene anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene formation" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901819 ! alpha-zeacarotene metabolic process

[Term]
id: GO:1901822
name: delta-carotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]
synonym: "delta-carotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0016119 ! carotene metabolic process

[Term]
id: GO:1901823
name: delta-carotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]
synonym: "delta-carotene breakdown" EXACT [GOC:TermGenie]
synonym: "delta-carotene catabolism" EXACT [GOC:TermGenie]
synonym: "delta-carotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901822 ! delta-carotene metabolic process

[Term]
id: GO:1901824
name: alpha-carotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]
synonym: "delta-carotene anabolism" EXACT [GOC:TermGenie]
synonym: "delta-carotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "delta-carotene biosynthetic process" EXACT []
synonym: "delta-carotene formation" EXACT [GOC:TermGenie]
synonym: "delta-carotene synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-5946
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016120 ! carotene biosynthetic process

[Term]
id: GO:1901825
name: zeaxanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]
synonym: "zeaxanthin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:1901826
name: zeaxanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]
synonym: "zeaxanthin breakdown" EXACT [GOC:TermGenie]
synonym: "zeaxanthin catabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901825 ! zeaxanthin metabolic process

[Term]
id: GO:1901827
name: zeaxanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]
synonym: "zeaxanthin anabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "zeaxanthin formation" EXACT [GOC:TermGenie]
synonym: "zeaxanthin synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-5944
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901825 ! zeaxanthin metabolic process

[Term]
id: GO:1901828
name: zeaxanthin bis(beta-D-glucoside) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]
synonym: "zeaxanthin bis(beta-D-glucoside) metabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin diglucoside metabolism" EXACT [GOC:yaf]
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:1901829
name: zeaxanthin bis(beta-D-glucoside) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]
synonym: "zeaxanthin bis(beta-D-glucoside) breakdown" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) catabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) degradation" EXACT [GOC:TermGenie]
synonym: "zeaxanthin diglucoside breakdown" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside catabolism" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside degradation" EXACT [GOC:yaf]
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:1901805 ! beta-glucoside catabolic process
is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process

[Term]
id: GO:1901830
name: zeaxanthin bis(beta-D-glucoside) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]
synonym: "zeaxanthin bis(beta-D-glucoside) anabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) biosynthesis" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) formation" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) synthesis" EXACT [GOC:TermGenie]
synonym: "zeaxanthin diglucoside anabolism" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside biosynthesis" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside formation" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside synthesis" EXACT [GOC:yaf]
xref: MetaCyc:PWY-6288
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process
is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process

[Term]
id: GO:1901831
name: all-trans-neoxanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]
synonym: "all-trans-neoxanthin metabolism" EXACT [GOC:TermGenie]
synonym: "neoxanthin metabolic process" EXACT [GOC:yaf]
synonym: "neoxanthin metabolism" EXACT [GOC:yaf]
is_a: GO:0016122 ! xanthophyll metabolic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:1901832
name: all-trans-neoxanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]
synonym: "all-trans-neoxanthin breakdown" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin catabolism" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin degradation" EXACT [GOC:TermGenie]
synonym: "neoxanthin breakdown" EXACT [GOC:yaf]
synonym: "neoxanthin catabolic process" EXACT [GOC:yaf]
synonym: "neoxanthin catabolism" EXACT [GOC:yaf]
synonym: "neoxanthin degradation" EXACT [GOC:yaf]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901831 ! all-trans-neoxanthin metabolic process

[Term]
id: GO:1901833
name: neoxanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trans-neoxanthin and 9'-cis-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]
synonym: "all-trans-neoxanthin anabolism" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin biosynthetic process" NARROW []
synonym: "all-trans-neoxanthin formation" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin synthesis" EXACT [GOC:TermGenie]
synonym: "neoxanthin anabolism" EXACT [GOC:yaf]
synonym: "neoxanthin biosynthesis" EXACT [GOC:yaf]
synonym: "neoxanthin formation" EXACT [GOC:yaf]
synonym: "neoxanthin synthesis" EXACT [GOC:yaf]
xref: MetaCyc:PWY-6809
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901831 ! all-trans-neoxanthin metabolic process

[Term]
id: GO:1901834
name: regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie]
synonym: "regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
is_a: GO:1903311 ! regulation of mRNA metabolic process
relationship: regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA

[Term]
id: GO:1901835
name: positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie]
synonym: "activation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "activation of deadenylation-independent decapping of nuclear-transcribed mRNA" NARROW [GOC:TermGenie]
synonym: "activation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "positive regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "positive regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "up regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "up regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "up-regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "up-regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "upregulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "upregulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:1901834 ! regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
relationship: positively_regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA

[Term]
id: GO:1901836
name: regulation of transcription of nucleolar large rRNA by RNA polymerase I
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]
synonym: "regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT []
synonym: "regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
is_a: GO:0006356 ! regulation of transcription by RNA polymerase I
relationship: regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I

[Term]
id: GO:1901837
name: negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT []
synonym: "negative regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I
is_a: GO:1901836 ! regulation of transcription of nucleolar large rRNA by RNA polymerase I
relationship: negatively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I

[Term]
id: GO:1901838
name: positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]
synonym: "activation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie]
synonym: "activation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT []
synonym: "positive regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I
is_a: GO:1901836 ! regulation of transcription of nucleolar large rRNA by RNA polymerase I
relationship: positively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I

[Term]
id: GO:1901839
name: regulation of RNA polymerase I regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding

[Term]
id: GO:1901840
name: negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA polymerase I regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1901839 ! regulation of RNA polymerase I regulatory region sequence-specific DNA binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding

[Term]
id: GO:1901841
name: regulation of high voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]
subset: gocheck_obsoletion_candidate
synonym: "regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity

[Term]
id: GO:1901842
name: negative regulation of high voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901386 ! negative regulation of voltage-gated calcium channel activity
is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity

[Term]
id: GO:1901843
name: positive regulation of high voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]
subset: gocheck_obsoletion_candidate
synonym: "activation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901387 ! positive regulation of voltage-gated calcium channel activity
is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity

[Term]
id: GO:1901844
name: regulation of cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
relationship: regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction

[Term]
id: GO:1901845
name: negative regulation of cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]
synonym: "down regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "downregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "inhibition of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie]
is_a: GO:0010651 ! negative regulation of cell communication by electrical coupling
is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction
relationship: negatively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction

[Term]
id: GO:1901846
name: positive regulation of cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]
synonym: "activation of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie]
synonym: "up regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "upregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
is_a: GO:0010650 ! positive regulation of cell communication by electrical coupling
is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction
relationship: positively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction

[Term]
id: GO:1901847
name: nicotinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]
synonym: "nicotinate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:1901848
name: nicotinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]
synonym: "nicotinate breakdown" EXACT [GOC:TermGenie]
synonym: "nicotinate catabolism" EXACT [GOC:TermGenie]
synonym: "nicotinate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901847 ! nicotinate metabolic process

[Term]
id: GO:1901849
name: nicotinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]
synonym: "nicotinate anabolism" EXACT [GOC:TermGenie]
synonym: "nicotinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "nicotinate formation" EXACT [GOC:TermGenie]
synonym: "nicotinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1901847 ! nicotinate metabolic process

[Term]
id: GO:1901850
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism" EXACT [GOC:TermGenie]
synonym: "coenzyme F0 metabolism" EXACT [GOC:yaf]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901851
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin breakdown" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolism" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin degradation" EXACT [GOC:TermGenie]
synonym: "coenzyme F0 breakdown" EXACT [GOC:yaf]
synonym: "coenzyme F0 catabolic process" EXACT [GOC:yaf]
synonym: "coenzyme F0 catabolism" EXACT [GOC:yaf]
synonym: "coenzyme F0 degradation" EXACT [GOC:yaf]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process

[Term]
id: GO:1901852
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin anabolism" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin formation" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthesis" EXACT [GOC:TermGenie]
synonym: "coenzyme F0 anabolism" EXACT [GOC:yaf]
synonym: "coenzyme F0 biosynthesis" EXACT [GOC:yaf]
synonym: "coenzyme F0 biosynthetic process" EXACT [GOC:yaf]
synonym: "coenzyme F0 formation" EXACT [GOC:yaf]
synonym: "coenzyme F0 synthesis" EXACT [GOC:yaf]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process

[Term]
id: GO:1901853
name: 5,6,7,8-tetrahydrosarcinapterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]
synonym: "5,6,7,8-tetrahydrosarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:2001117 ! tetrahydromethanopterin metabolic process

[Term]
id: GO:1901854
name: 5,6,7,8-tetrahydrosarcinapterin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]
synonym: "5,6,7,8-tetrahydrosarcinapterin breakdown" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin catabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin degradation" EXACT [GOC:TermGenie]
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process
is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process

[Term]
id: GO:1901855
name: 5,6,7,8-tetrahydrosarcinapterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]
synonym: "5,6,7,8-tetrahydrosarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process
is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process

[Term]
id: GO:1901856
name: negative regulation of cellular respiration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of respiration" BROAD [GOC:TermGenie]
synonym: "down-regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of respiration" BROAD [GOC:TermGenie]
synonym: "downregulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of respiration" BROAD [GOC:TermGenie]
synonym: "inhibition of cellular respiration" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of respiration" BROAD [GOC:TermGenie]
synonym: "negative regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of respiration" BROAD [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
relationship: negatively_regulates GO:0045333 ! cellular respiration

[Term]
id: GO:1901857
name: positive regulation of cellular respiration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of cellular respiration" NARROW [GOC:TermGenie]
synonym: "activation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "activation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "activation of respiration" BROAD [GOC:TermGenie]
synonym: "positive regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of respiration" BROAD [GOC:TermGenie]
synonym: "up regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of respiration" BROAD [GOC:TermGenie]
synonym: "up-regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiration" BROAD [GOC:TermGenie]
synonym: "upregulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of respiration" BROAD [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
relationship: positively_regulates GO:0045333 ! cellular respiration

[Term]
id: GO:1901858
name: regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:1901859
name: negative regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
relationship: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:1901860
name: positive regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
relationship: positively_regulates GO:0007005 ! mitochondrion organization
relationship: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:1901861
name: regulation of muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0060537 ! muscle tissue development

[Term]
id: GO:1901862
name: negative regulation of muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
relationship: negatively_regulates GO:0060537 ! muscle tissue development

[Term]
id: GO:1901863
name: positive regulation of muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie]
synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
relationship: positively_regulates GO:0060537 ! muscle tissue development

[Term]
id: GO:1901864
name: capsorubin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving capsorubin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807]
synonym: "capsorubin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:1901865
name: capsorubin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of capsorubin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807]
synonym: "capsorubin breakdown" EXACT [GOC:TermGenie]
synonym: "capsorubin catabolism" EXACT [GOC:TermGenie]
synonym: "capsorubin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901864 ! capsorubin metabolic process

[Term]
id: GO:1901866
name: capsorubin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]
synonym: "capsorubin anabolism" EXACT [GOC:TermGenie]
synonym: "capsorubin biosynthesis" EXACT [GOC:TermGenie]
synonym: "capsorubin formation" EXACT [GOC:TermGenie]
synonym: "capsorubin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901864 ! capsorubin metabolic process

[Term]
id: GO:1901867
name: ecgonine methyl ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecgonine methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonine methyl ester metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046448 ! tropane alkaloid metabolic process

[Term]
id: GO:1901868
name: ecgonine methyl ester catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonine methyl ester breakdown" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester catabolism" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:1901867 ! ecgonine methyl ester metabolic process

[Term]
id: GO:1901869
name: ecgonine methyl ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonine methyl ester anabolism" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester formation" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:1901867 ! ecgonine methyl ester metabolic process

[Term]
id: GO:1901870
name: ecgonone methyl ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecgonone methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonone methyl ester metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0046448 ! tropane alkaloid metabolic process

[Term]
id: GO:1901871
name: ecgonone methyl ester catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonone methyl ester breakdown" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester catabolism" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901870 ! ecgonone methyl ester metabolic process

[Term]
id: GO:1901872
name: ecgonone methyl ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonone methyl ester anabolism" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester formation" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901870 ! ecgonone methyl ester metabolic process

[Term]
id: GO:1901873
name: regulation of post-translational protein modification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]
synonym: "regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "regulation of PTM" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0043687 ! post-translational protein modification

[Term]
id: GO:1901874
name: negative regulation of post-translational protein modification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]
synonym: "down regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "down regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "down regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "down regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "down regulation of PTM" EXACT [GOC:TermGenie]
synonym: "down-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of PTM" EXACT [GOC:TermGenie]
synonym: "downregulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "downregulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "downregulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "downregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "downregulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "downregulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "downregulation of PTM" EXACT [GOC:TermGenie]
synonym: "inhibition of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "inhibition of post-translational modification" EXACT [GOC:TermGenie]
synonym: "inhibition of post-translational protein modification" NARROW [GOC:TermGenie]
synonym: "inhibition of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "inhibition of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "inhibition of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "inhibition of PTM" EXACT [GOC:TermGenie]
synonym: "negative regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of PTM" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1901873 ! regulation of post-translational protein modification
relationship: negatively_regulates GO:0043687 ! post-translational protein modification

[Term]
id: GO:1901875
name: positive regulation of post-translational protein modification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]
synonym: "activation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "activation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "activation of post-translational protein modification" NARROW [GOC:TermGenie]
synonym: "activation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "activation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "activation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "activation of PTM" EXACT [GOC:TermGenie]
synonym: "positive regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of PTM" EXACT [GOC:TermGenie]
synonym: "up regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "up regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "up regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "up regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "up regulation of PTM" EXACT [GOC:TermGenie]
synonym: "up-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of PTM" EXACT [GOC:TermGenie]
synonym: "upregulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "upregulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "upregulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "upregulation of PTM" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1901873 ! regulation of post-translational protein modification
relationship: positively_regulates GO:0043687 ! post-translational protein modification

[Term]
id: GO:1901876
name: regulation of calcium ion binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
subset: gocheck_do_not_annotate
synonym: "regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:1901877
name: negative regulation of calcium ion binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
subset: gocheck_do_not_annotate
synonym: "down regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "downregulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "inhibition of calcium ion binding" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1901876 ! regulation of calcium ion binding

[Term]
id: GO:1901878
name: positive regulation of calcium ion binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
subset: gocheck_do_not_annotate
synonym: "activation of calcium ion binding" NARROW [GOC:TermGenie]
synonym: "activation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "up regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "upregulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1901876 ! regulation of calcium ion binding

[Term]
id: GO:1901879
name: regulation of protein depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
relationship: regulates GO:0051261 ! protein depolymerization

[Term]
id: GO:1901880
name: negative regulation of protein depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
relationship: negatively_regulates GO:0051261 ! protein depolymerization

[Term]
id: GO:1901881
name: positive regulation of protein depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
relationship: positively_regulates GO:0051261 ! protein depolymerization

[Term]
id: GO:1901882
name: 4-hydroxycoumarin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-hydroxycoumarin." [GOC:TermGenie, PMID:19757094]
synonym: "4-hydroxycoumarin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009804 ! coumarin metabolic process

[Term]
id: GO:1901883
name: 4-hydroxycoumarin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxycoumarin." [GOC:TermGenie, PMID:19757094]
synonym: "4-hydroxycoumarin breakdown" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin catabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046226 ! coumarin catabolic process
is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process

[Term]
id: GO:1901884
name: 4-hydroxycoumarin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxycoumarin." [GOC:TermGenie, PMID:19757094]
synonym: "4-hydroxycoumarin anabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin biosynthesis" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin formation" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process

[Term]
id: GO:1901885
name: 2-hydroxybenzoyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-hydroxybenzoyl-CoA." [GOC:TermGenie, PMID:19757094]
synonym: "2-hydroxybenzoyl-CoA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006637 ! acyl-CoA metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:1901886
name: 2-hydroxybenzoyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, PMID:19757094]
synonym: "2-hydroxybenzoyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process
is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process

[Term]
id: GO:1901887
name: 2-hydroxybenzoyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, PMID:19757094]
synonym: "2-hydroxybenzoyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process
is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process

[Term]
id: GO:1901888
name: regulation of cell junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0034329 ! cell junction assembly

[Term]
id: GO:1901889
name: negative regulation of cell junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
relationship: negatively_regulates GO:0034329 ! cell junction assembly

[Term]
id: GO:1901890
name: positive regulation of cell junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
relationship: positively_regulates GO:0034329 ! cell junction assembly

[Term]
id: GO:1901891
name: regulation of cell septum assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell septum assembly." [GOC:TermGenie]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0090529 ! cell septum assembly

[Term]
id: GO:1901892
name: negative regulation of cell septum assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly." [GOC:TermGenie]
synonym: "down regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cell septum assembly" NARROW [GOC:TermGenie]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901891 ! regulation of cell septum assembly
relationship: negatively_regulates GO:0090529 ! cell septum assembly

[Term]
id: GO:1901893
name: positive regulation of cell septum assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell septum assembly." [GOC:TermGenie]
synonym: "activation of cell septum assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell septum assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1901891 ! regulation of cell septum assembly
relationship: positively_regulates GO:0090529 ! cell septum assembly

[Term]
id: GO:1901894
name: regulation of ATPase-coupled calcium transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "regulation of calcium-transporting ATPase activity" EXACT []
synonym: "regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
is_a: GO:0043462 ! regulation of ATP-dependent activity
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity

[Term]
id: GO:1901895
name: negative regulation of ATPase-coupled calcium transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "down regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "down regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "down regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "down-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "down-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "downregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "downregulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "downregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "inhibition of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium pump" BROAD [GOC:TermGenie]
synonym: "inhibition of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "negative regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium-transporting ATPase activity" EXACT []
synonym: "negative regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATP-dependent activity
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:1901894 ! regulation of ATPase-coupled calcium transmembrane transporter activity

[Term]
id: GO:1901896
name: positive regulation of ATPase-coupled calcium transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
subset: gocheck_obsoletion_candidate
synonym: "activation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "activation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "activation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "activation of calcium pump" BROAD [GOC:TermGenie]
synonym: "activation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of calcium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "activation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "activation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "positive regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium-transporting ATPase activity" EXACT []
synonym: "positive regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "up regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "up regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "up-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "up-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "upregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "upregulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "upregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATP-dependent activity
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1901894 ! regulation of ATPase-coupled calcium transmembrane transporter activity

[Term]
id: GO:1901897
name: regulation of relaxation of cardiac muscle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
is_a: GO:1901077 ! regulation of relaxation of muscle
relationship: regulates GO:0055119 ! relaxation of cardiac muscle

[Term]
id: GO:1901898
name: negative regulation of relaxation of cardiac muscle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
synonym: "down regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "down-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "downregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "inhibition of relaxation of cardiac muscle" NARROW [GOC:TermGenie]
is_a: GO:1901078 ! negative regulation of relaxation of muscle
is_a: GO:1901897 ! regulation of relaxation of cardiac muscle
relationship: negatively_regulates GO:0055119 ! relaxation of cardiac muscle

[Term]
id: GO:1901899
name: positive regulation of relaxation of cardiac muscle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
synonym: "activation of relaxation of cardiac muscle" NARROW [GOC:TermGenie]
synonym: "up regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "up-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "upregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
is_a: GO:1901079 ! positive regulation of relaxation of muscle
is_a: GO:1901897 ! regulation of relaxation of cardiac muscle
relationship: positively_regulates GO:0055119 ! relaxation of cardiac muscle

[Term]
id: GO:1901900
name: regulation of protein localization to cell division site
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell division site." [GOC:dph, GOC:TermGenie, PMID:22573892]
synonym: "regulation of protein localisation to cell division site" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0072741 ! protein localization to cell division site

[Term]
id: GO:1901901
name: regulation of protein localization to cell division site involved in cytokinesis
namespace: biological_process
def: "Any regulation of protein localization to cell division site that is involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892]
synonym: "regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:1901900 ! regulation of protein localization to cell division site
relationship: part_of GO:0000910 ! cytokinesis

[Term]
id: GO:1901902
name: tyrocidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938]
synonym: "tyrocidine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1901903
name: tyrocidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938]
synonym: "tyrocidine breakdown" EXACT [GOC:TermGenie]
synonym: "tyrocidine catabolism" EXACT [GOC:TermGenie]
synonym: "tyrocidine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901902 ! tyrocidine metabolic process

[Term]
id: GO:1901904
name: tyrocidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938, UniPathway:UPA00180]
synonym: "tyrocidine anabolism" EXACT [GOC:TermGenie]
synonym: "tyrocidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "tyrocidine formation" EXACT [GOC:TermGenie]
synonym: "tyrocidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901902 ! tyrocidine metabolic process

[Term]
id: GO:1901905
name: response to tamsulosin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tamsulosin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0014075 ! response to amine
is_a: GO:0045472 ! response to ether

[Term]
id: GO:1901906
name: diadenosine pentaphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine pentaphosphate metabolism" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate metabolic process" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:1901907
name: diadenosine pentaphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine pentaphosphate catabolism" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "diadenosyl pentaphosphate catabolic process" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "diadenosyl pentaphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:1901906 ! diadenosine pentaphosphate metabolic process

[Term]
id: GO:1901908
name: diadenosine hexaphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine hexaphosphate metabolism" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate metabolic process" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:1901909
name: diadenosine hexaphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine hexaphosphate catabolism" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "diadenosyl hexaphosphate catabolic process" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "diadenosyl hexaphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:1901908 ! diadenosine hexaphosphate metabolic process

[Term]
id: GO:1901910
name: adenosine 5'-(hexahydrogen pentaphosphate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009150 ! purine ribonucleotide metabolic process

[Term]
id: GO:1901911
name: adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) breakdown" EXACT [GOC:TermGenie]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) catabolism" EXACT [GOC:TermGenie]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) degradation" EXACT [GOC:TermGenie]
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:1901910 ! adenosine 5'-(hexahydrogen pentaphosphate) metabolic process

[Term]
id: GO:1901913
name: regulation of capsule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie]
synonym: "regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0045230 ! capsule organization

[Term]
id: GO:1901914
name: negative regulation of capsule organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie]
synonym: "down regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "down regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "downregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of capsule organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of capsule organization" NARROW [GOC:TermGenie]
synonym: "inhibition of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901913 ! regulation of capsule organization
relationship: negatively_regulates GO:0045230 ! capsule organization

[Term]
id: GO:1901915
name: positive regulation of capsule organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie]
synonym: "activation of capsule organisation" NARROW [GOC:TermGenie]
synonym: "activation of capsule organization" NARROW [GOC:TermGenie]
synonym: "activation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "up regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "upregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901913 ! regulation of capsule organization
relationship: positively_regulates GO:0045230 ! capsule organization

[Term]
id: GO:1901916
name: obsolete protein kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis
namespace: molecular_function
def: "OBSOLETE. Any protein kinase activity that is involved in regulation of protein localization to cell division site involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892]
comment: This term was obsoleted is that this term represents both a function and a process.
synonym: "protamine kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" NARROW [GOC:TermGenie]
synonym: "protamine kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis" NARROW [GOC:TermGenie]
synonym: "protein kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901917
name: regulation of exoribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495]
subset: gocheck_obsoletion_candidate
is_a: GO:0060700 ! regulation of ribonuclease activity
is_a: GO:1905777 ! regulation of exonuclease activity

[Term]
id: GO:1901918
name: negative regulation of exoribonuclease activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "inhibition of exoribonuclease activity" NARROW [GOC:TermGenie]
is_a: GO:0060701 ! negative regulation of ribonuclease activity
is_a: GO:1901917 ! regulation of exoribonuclease activity
is_a: GO:1905778 ! negative regulation of exonuclease activity

[Term]
id: GO:1901919
name: positive regulation of exoribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495]
subset: gocheck_obsoletion_candidate
synonym: "activation of exoribonuclease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exoribonuclease activity" EXACT [GOC:TermGenie]
is_a: GO:1901917 ! regulation of exoribonuclease activity
is_a: GO:1905779 ! positive regulation of exonuclease activity

[Term]
id: GO:1901920
name: obsolete peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity
namespace: biological_process
def: "OBSOLETE. Any peptidyl-tyrosine dephosphorylation that is involved in activation of protein kinase activity." [GOC:TermGenie, PMID:1756737]
comment: This term was obsoleted because it represents a molecular function.
synonym: "peptidyl-tyrosine dephosphorylation involved in protein kinase activation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901921
name: obsolete phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain that is involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex." [GOC:TermGenie, PMID:10594013]
comment: This term was obsoleted because it represents both a molecular function and a biological process.
synonym: "CTD domain phosphorylation of RNA polymerase II involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0008353
consider: GO:0031124

[Term]
id: GO:1901922
name: regulation of sclerotium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:1990045 ! sclerotium development

[Term]
id: GO:1901923
name: negative regulation of sclerotium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914]
synonym: "down regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "down-regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "downregulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "inhibition of sclerotium development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901922 ! regulation of sclerotium development
relationship: negatively_regulates GO:1990045 ! sclerotium development

[Term]
id: GO:1901924
name: positive regulation of sclerotium development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914]
synonym: "activation of sclerotium development" NARROW [GOC:TermGenie]
synonym: "up regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "up-regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "upregulation of sclerotium development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901922 ! regulation of sclerotium development
relationship: positively_regulates GO:1990045 ! sclerotium development

[Term]
id: GO:1901925
name: negative regulation of protein import into nucleus during spindle assembly checkpoint
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p)." [GOC:dgf, GOC:TermGenie, PMID:23177738]
synonym: "Kap121p transport inhibitory pathway" RELATED []
synonym: "KTIP" RELATED []
synonym: "negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint" EXACT []
is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling

[Term]
id: GO:1901926
name: cadinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cadinene." [GOC:TermGenie, PMID:22867794]
synonym: "cadinene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:1901927
name: cadinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cadinene." [GOC:TermGenie, PMID:22867794]
synonym: "cadinene breakdown" EXACT [GOC:TermGenie]
synonym: "cadinene catabolism" EXACT [GOC:TermGenie]
synonym: "cadinene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901926 ! cadinene metabolic process

[Term]
id: GO:1901928
name: cadinene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cadinene." [GOC:TermGenie, PMID:22867794]
synonym: "cadinene anabolism" EXACT [GOC:TermGenie]
synonym: "cadinene biosynthesis" EXACT [GOC:TermGenie]
synonym: "cadinene formation" EXACT [GOC:TermGenie]
synonym: "cadinene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901926 ! cadinene metabolic process

[Term]
id: GO:1901929
name: alpha-copaene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-copaene." [GOC:TermGenie, PMID:22867794]
synonym: "alpha-copaene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:1901930
name: alpha-copaene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-copaene." [GOC:TermGenie, PMID:22867794]
synonym: "alpha-copaene breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-copaene catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-copaene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901929 ! alpha-copaene metabolic process

[Term]
id: GO:1901931
name: alpha-copaene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-copaene." [GOC:TermGenie, PMID:22867794]
synonym: "alpha-copaene anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-copaene biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-copaene formation" EXACT [GOC:TermGenie]
synonym: "alpha-copaene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901929 ! alpha-copaene metabolic process

[Term]
id: GO:1901932
name: bicyclogermacrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bicyclogermacrene." [GOC:TermGenie, PMID:22867794]
synonym: "bicyclogermacrene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:1901933
name: bicyclogermacrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bicyclogermacrene." [GOC:TermGenie, PMID:22867794]
synonym: "bicyclogermacrene breakdown" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene catabolism" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901932 ! bicyclogermacrene metabolic process

[Term]
id: GO:1901934
name: bicyclogermacrene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bicyclogermacrene." [GOC:TermGenie, PMID:22867794]
synonym: "bicyclogermacrene anabolism" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene biosynthesis" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene formation" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901932 ! bicyclogermacrene metabolic process

[Term]
id: GO:1901935
name: beta-caryophyllene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-caryophyllene." [GOC:TermGenie, PMID:22867794]
synonym: "beta-caryophyllene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:1901936
name: beta-caryophyllene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-caryophyllene." [GOC:TermGenie, PMID:22867794]
synonym: "beta-caryophyllene breakdown" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene catabolism" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901935 ! beta-caryophyllene metabolic process

[Term]
id: GO:1901937
name: beta-caryophyllene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-caryophyllene." [GOC:TermGenie, PMID:22867794]
synonym: "beta-caryophyllene anabolism" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene formation" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901935 ! beta-caryophyllene metabolic process

[Term]
id: GO:1901938
name: (-)-exo-alpha-bergamotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-exo-alpha-bergamotene." [GOC:TermGenie, PMID:22867794]
synonym: "(-)-exo-alpha-bergamotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:1901939
name: (-)-exo-alpha-bergamotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-exo-alpha-bergamotene." [GOC:TermGenie, PMID:22867794]
synonym: "(-)-exo-alpha-bergamotene breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process

[Term]
id: GO:1901940
name: (-)-exo-alpha-bergamotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-exo-alpha-bergamotene." [GOC:TermGenie, PMID:22867794]
synonym: "(-)-exo-alpha-bergamotene anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene formation" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1900674 ! olefin biosynthetic process
is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process

[Term]
id: GO:1901941
name: (+)-epi-alpha-bisabolol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-epi-alpha-bisabolol." [GOC:TermGenie, PMID:22867794]
synonym: "(+)-epi-alpha-bisabolol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process

[Term]
id: GO:1901942
name: (+)-epi-alpha-bisabolol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-epi-alpha-bisabolol." [GOC:TermGenie, PMID:22867794]
synonym: "(+)-epi-alpha-bisabolol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol degradation" EXACT [GOC:TermGenie]
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process

[Term]
id: GO:1901943
name: (+)-epi-alpha-bisabolol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-epi-alpha-bisabolol." [GOC:TermGenie, PMID:22867794]
synonym: "(+)-epi-alpha-bisabolol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol formation" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process

[Term]
id: GO:1901944
name: miltiradiene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving miltiradiene." [GOC:TermGenie, PMID:22027823]
synonym: "miltiradiene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:1901945
name: miltiradiene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of miltiradiene." [GOC:TermGenie, PMID:22027823]
synonym: "miltiradiene breakdown" EXACT [GOC:TermGenie]
synonym: "miltiradiene catabolism" EXACT [GOC:TermGenie]
synonym: "miltiradiene degradation" EXACT [GOC:TermGenie]
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:1901944 ! miltiradiene metabolic process

[Term]
id: GO:1901946
name: miltiradiene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of miltiradiene." [GOC:TermGenie, PMID:22027823]
synonym: "miltiradiene anabolism" EXACT [GOC:TermGenie]
synonym: "miltiradiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "miltiradiene formation" EXACT [GOC:TermGenie]
synonym: "miltiradiene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1901944 ! miltiradiene metabolic process

[Term]
id: GO:1901947
name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, PMID:22027823]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0016101 ! diterpenoid metabolic process

[Term]
id: GO:1901948
name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, PMID:22027823]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process

[Term]
id: GO:1901949
name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, PMID:22027823]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate formation" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process

[Term]
id: GO:1901950
name: dense core granule transport
namespace: biological_process
def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451]
comment: goslim_synapse
synonym: "dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0032253 ! dense core granule localization
is_a: GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:1901951
name: regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1904809 ! regulation of dense core granule transport
relationship: regulates GO:1990048 ! anterograde neuronal dense core vesicle transport

[Term]
id: GO:1901952
name: negative regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1901951 ! regulation of anterograde dense core granule transport
is_a: GO:1904810 ! negative regulation of dense core granule transport
relationship: negatively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport

[Term]
id: GO:1901953
name: positive regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1901951 ! regulation of anterograde dense core granule transport
is_a: GO:1904811 ! positive regulation of dense core granule transport
relationship: positively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport

[Term]
id: GO:1901954
name: regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1904809 ! regulation of dense core granule transport
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
relationship: regulates GO:1990049 ! retrograde neuronal dense core vesicle transport

[Term]
id: GO:1901955
name: negative regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1901954 ! regulation of retrograde dense core granule transport
is_a: GO:1904810 ! negative regulation of dense core granule transport
is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport
relationship: negatively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport

[Term]
id: GO:1901956
name: positive regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie]
synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1901954 ! regulation of retrograde dense core granule transport
is_a: GO:1904811 ! positive regulation of dense core granule transport
is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport
relationship: positively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport

[Term]
id: GO:1901957
name: regulation of cutin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127]
synonym: "regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "regulation of cutin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0010143 ! cutin biosynthetic process

[Term]
id: GO:1901958
name: negative regulation of cutin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127]
synonym: "down regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cutin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:1901957 ! regulation of cutin biosynthetic process
relationship: negatively_regulates GO:0010143 ! cutin biosynthetic process

[Term]
id: GO:1901959
name: positive regulation of cutin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127]
synonym: "activation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of cutin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of cutin formation" EXACT [GOC:TermGenie]
synonym: "activation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:1901957 ! regulation of cutin biosynthetic process
relationship: positively_regulates GO:0010143 ! cutin biosynthetic process

[Term]
id: GO:1901960
name: isobutanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870]
synonym: "isobutanol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:1901961
name: isobutanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870]
synonym: "isobutanol anabolism" EXACT [GOC:TermGenie]
synonym: "isobutanol biosynthesis" EXACT [GOC:TermGenie]
synonym: "isobutanol formation" EXACT [GOC:TermGenie]
synonym: "isobutanol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1901960 ! isobutanol metabolic process

[Term]
id: GO:1901962
name: S-adenosyl-L-methionine transmembrane transport
namespace: biological_process
def: "The directed movement of S-adenosyl-L-methionine across a membrane." [GOC:TermGenie, PMID:10497160]
synonym: "S-adenosylmethionine transmembrane transport" EXACT []
synonym: "SAM transmembrane transport" EXACT []
is_a: GO:0015805 ! S-adenosyl-L-methionine transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1901963
name: regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
relationship: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis

[Term]
id: GO:1901964
name: positive regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
relationship: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis

[Term]
id: GO:1901965
name: endoplasmic reticulum to chloroplast transport
namespace: biological_process
def: "The directed movement of substances from endoplasmic reticulum to chloroplast." [GOC:TermGenie, PMID:18689504]
synonym: "ER to chloroplast transport" EXACT [GOC:TermGenie]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:1901966
name: regulation of cellular response to iron ion starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010106 ! cellular response to iron ion starvation

[Term]
id: GO:1901967
name: negative regulation of cellular response to iron ion starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244]
synonym: "down regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to iron ion starvation" NARROW [GOC:TermGenie]
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1901966 ! regulation of cellular response to iron ion starvation
relationship: negatively_regulates GO:0010106 ! cellular response to iron ion starvation

[Term]
id: GO:1901968
name: regulation of polynucleotide 3'-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:1901969
name: obsolete positive regulation of polynucleotide 3'-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "activation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "activation of polynucleotide 3'-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901970
name: positive regulation of mitotic sister chromatid separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation." [GOC:TermGenie, PMID:1846086]
synonym: "activation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "activation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "activation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "activation of mitotic sister chromatid separation" NARROW [GOC:TermGenie]
synonym: "activation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "positive regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "up regulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "up regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie]
synonym: "up regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "upregulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "upregulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie]
synonym: "upregulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
is_a: GO:1905820 ! positive regulation of chromosome separation
relationship: positively_regulates GO:0051306 ! mitotic sister chromatid separation

[Term]
id: GO:1901971
name: obsolete regulation of DNA-5-methylcytosine glycosylase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1901972
name: obsolete positive regulation of DNA-5-methylcytosine glycosylase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of DNA-5-methylcytosine glycosylase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1901973
name: proline binding
namespace: molecular_function
def: "Binding to proline." [GOC:pm, GOC:TermGenie, PMID:7730362]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:1901974
name: glycerate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerate from one side of a membrane to the other." [GOC:TermGenie, PMID:23382251]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:1901975
name: glycerate transmembrane transport
namespace: biological_process
def: "The process in which glycerate is transported across a membrane." [GOC:TermGenie, PMID:23382251]
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0042873 ! aldonate transmembrane transport

[Term]
id: GO:1901976
name: regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001047
def: "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
synonym: "regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "regulation of G1/S transition checkpoint" RELATED []
is_a: GO:1901987 ! regulation of cell cycle phase transition
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0000075 ! cell cycle checkpoint signaling

[Term]
id: GO:1901977
name: negative regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001048
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
synonym: "down regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle checkpoint" NARROW [GOC:TermGenie]
synonym: "negative regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "negative regulation of G1/S transition checkpoint" RELATED []
is_a: GO:1901976 ! regulation of cell cycle checkpoint
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0000075 ! cell cycle checkpoint signaling

[Term]
id: GO:1901978
name: positive regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001052
def: "Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
synonym: "activation of cell cycle checkpoint" NARROW [GOC:TermGenie]
synonym: "positive regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "positive regulation of G1/S transition checkpoint" RELATED []
synonym: "up regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1901976 ! regulation of cell cycle checkpoint
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0000075 ! cell cycle checkpoint signaling

[Term]
id: GO:1901979
name: regulation of inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501]
subset: gocheck_obsoletion_candidate
synonym: "regulation of Kir channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1901980
name: positive regulation of inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501]
subset: gocheck_obsoletion_candidate
synonym: "activation of inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Kir channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity
is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity

[Term]
id: GO:1901981
name: phosphatidylinositol phosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]
is_a: GO:0035091 ! phosphatidylinositol binding

[Term]
id: GO:1901982
name: maltose binding
namespace: molecular_function
def: "Binding to maltose." [GOC:TermGenie, PMID:21566157]
is_a: GO:0048030 ! disaccharide binding

[Term]
id: GO:1901983
name: regulation of protein acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0006473 ! protein acetylation

[Term]
id: GO:1901984
name: negative regulation of protein acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein acetylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein amino acid acetylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1901983 ! regulation of protein acetylation
relationship: negatively_regulates GO:0006473 ! protein acetylation

[Term]
id: GO:1901985
name: positive regulation of protein acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein acetylation" NARROW [GOC:TermGenie]
synonym: "activation of protein amino acid acetylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1901983 ! regulation of protein acetylation
relationship: positively_regulates GO:0006473 ! protein acetylation

[Term]
id: GO:1901986
name: response to ketamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus." [GOC:TermGenie, PMID:11251190]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1901987
name: regulation of cell cycle phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "cell cycle control" EXACT [GOC:vw]
synonym: "regulation of cell cycle transition" EXACT [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0044770 ! cell cycle phase transition

[Term]
id: GO:1901988
name: negative regulation of cell cycle phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "down regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "inhibition of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell cycle transition" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1901987 ! regulation of cell cycle phase transition
relationship: negatively_regulates GO:0044770 ! cell cycle phase transition

[Term]
id: GO:1901989
name: positive regulation of cell cycle phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "activation of cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "activation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "up regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle transition" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1901987 ! regulation of cell cycle phase transition
relationship: positively_regulates GO:0044770 ! cell cycle phase transition

[Term]
id: GO:1901990
name: regulation of mitotic cell cycle phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "mitotic cell cycle control" EXACT [GOC:vw]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:1901987 ! regulation of cell cycle phase transition
relationship: regulates GO:0044772 ! mitotic cell cycle phase transition

[Term]
id: GO:1901991
name: negative regulation of mitotic cell cycle phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "down regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic cell cycle phase transition" NARROW [GOC:TermGenie]
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
relationship: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition

[Term]
id: GO:1901992
name: positive regulation of mitotic cell cycle phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "activation of mitotic cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
relationship: positively_regulates GO:0044772 ! mitotic cell cycle phase transition

[Term]
id: GO:1901993
name: regulation of meiotic cell cycle phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "meiotic cell cycle control" EXACT [GOC:vw]
synonym: "regulation of cell cycle transition" BROAD [GOC:TermGenie]
is_a: GO:1901987 ! regulation of cell cycle phase transition
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0044771 ! meiotic cell cycle phase transition

[Term]
id: GO:1901994
name: negative regulation of meiotic cell cycle phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "down regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "down regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "down-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "downregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "inhibition of meiotic cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell cycle transition" BROAD [GOC:TermGenie]
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
relationship: negatively_regulates GO:0044771 ! meiotic cell cycle phase transition

[Term]
id: GO:1901995
name: positive regulation of meiotic cell cycle phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "activation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "activation of meiotic cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "up regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "up regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "up-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "upregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
relationship: positively_regulates GO:0044771 ! meiotic cell cycle phase transition

[Term]
id: GO:1901996
name: regulation of indoleacetic acid biosynthetic process via tryptophan
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040]
synonym: "regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
is_a: GO:0010600 ! regulation of auxin biosynthetic process
is_a: GO:0090357 ! regulation of tryptophan metabolic process
relationship: regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan

[Term]
id: GO:1901997
name: negative regulation of indoleacetic acid biosynthetic process via tryptophan
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040]
synonym: "down regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid biosynthetic process via tryptophan" NARROW [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0090356 ! negative regulation of auxin metabolic process
is_a: GO:1901996 ! regulation of indoleacetic acid biosynthetic process via tryptophan
relationship: negatively_regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan

[Term]
id: GO:1901998
name: obsolete toxin transport
namespace: biological_process
def: "OBSOLETE. The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:17118486]
comment: The reason for obsoletion is that the term toxin transport is vague.
is_obsolete: true
consider: GO:1990748

[Term]
id: GO:1901999
name: homogentisate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homogentisate." [GOC:TermGenie, PMID:22980205]
synonym: "homogentisate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:1902000
name: homogentisate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homogentisate." [GOC:TermGenie, PMID:22980205]
synonym: "homogentisate breakdown" EXACT [GOC:TermGenie]
synonym: "homogentisate catabolism" EXACT [GOC:TermGenie]
synonym: "homogentisate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901999 ! homogentisate metabolic process

[Term]
id: GO:1902001
name: fatty acid transmembrane transport
namespace: biological_process
def: "The process in which a fatty acid is transported across a membrane." [GOC:rb, GOC:TermGenie, PMID:9395310]
is_a: GO:0015908 ! fatty acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1902002
name: obsolete protein phosphorylation involved in cellular protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any protein phosphorylation that is involved in cellular protein catabolic process." [GOC:rb, GOC:TermGenie, PMID:21098119, PMID:21993622, PMID:23264631]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "protein amino acid phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "protein amino acid phosphorylation involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "protein amino acid phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "protein amino acid phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "protein phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "protein phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "protein phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902003
name: regulation of amyloid-beta formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871]
synonym: "regulation of beta-amyloid formation" EXACT []
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
relationship: regulates GO:0034205 ! amyloid-beta formation

[Term]
id: GO:1902004
name: positive regulation of amyloid-beta formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871]
synonym: "activation of beta-amyloid formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-amyloid formation" EXACT []
synonym: "up regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-amyloid formation" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:1902003 ! regulation of amyloid-beta formation
is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process
relationship: positively_regulates GO:0034205 ! amyloid-beta formation

[Term]
id: GO:1902005
name: regulation of proline biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322]
synonym: "regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "regulation of proline synthesis" EXACT [GOC:TermGenie]
is_a: GO:2000214 ! regulation of proline metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0006561 ! proline biosynthetic process

[Term]
id: GO:1902006
name: negative regulation of proline biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322]
synonym: "down regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of proline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "down regulation of proline synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proline formation" EXACT [GOC:TermGenie]
synonym: "downregulation of proline synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of proline anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of proline biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proline formation" EXACT [GOC:TermGenie]
synonym: "inhibition of proline synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902005 ! regulation of proline biosynthetic process
is_a: GO:2000215 ! negative regulation of proline metabolic process
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:0006561 ! proline biosynthetic process

[Term]
id: GO:1902007
name: obsolete regulation of toxin transport
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315]
comment: The reason for obsoletion is that the term toxin transport is vague.
is_obsolete: true

[Term]
id: GO:1902008
name: obsolete negative regulation of toxin transport
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315]
comment: The reason for obsoletion is that the term toxin transport is vague.
synonym: "down regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "downregulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "inhibition of toxin transport" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902009
name: obsolete positive regulation of toxin transport
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315]
comment: The reason for obsoletion is that the term toxin transport is vague.
synonym: "activation of toxin transport" NARROW [GOC:TermGenie]
synonym: "up regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "upregulation of toxin transport" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902010
name: negative regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:dph, GOC:TermGenie, PMID:10882126]
synonym: "down regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "down regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "downregulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "inhibition of protein biosynthetic process involved in ER stress response" NARROW [GOC:TermGenie]
synonym: "inhibition of protein biosynthetic process involved in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of protein biosynthetic process involved in response to ER stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein anabolism involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein anabolism involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein anabolism involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthesis involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthesis involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein formation involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein formation involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein formation involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein synthesis involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein synthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein synthesis involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "protein biosynthesis inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie]
synonym: "protein biosynthesis inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "protein biosynthesis inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie]
synonym: "protein biosynthetic process inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie]
synonym: "protein biosynthetic process inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "protein biosynthetic process inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress

[Term]
id: GO:1902011
name: poly(ribitol phosphate) teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790]
synonym: "poly(ribitol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:1902012
name: poly(ribitol phosphate) teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790]
synonym: "poly(ribitol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie]
synonym: "poly(ribitol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(ribitol phosphate) teichoic acid formation" EXACT [GOC:TermGenie]
synonym: "poly(ribitol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:1902011 ! poly(ribitol phosphate) teichoic acid metabolic process

[Term]
id: GO:1902013
name: poly(glycerol phosphate) teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827]
synonym: "poly(glycerol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:1902014
name: poly(glycerol phosphate) teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827]
synonym: "poly(glycerol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie]
synonym: "poly(glycerol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(glycerol phosphate) teichoic acid formation" EXACT [GOC:TermGenie]
synonym: "poly(glycerol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:1902013 ! poly(glycerol phosphate) teichoic acid metabolic process

[Term]
id: GO:1902015
name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie]
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process" EXACT []
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT []
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:1902016
name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid formation" EXACT [GOC:TermGenie]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie]
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT []
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process" EXACT []
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:1902015 ! poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process

[Term]
id: GO:1902017
name: regulation of cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0060271 ! cilium assembly

[Term]
id: GO:1902018
name: negative regulation of cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0060271 ! cilium assembly

[Term]
id: GO:1902019
name: regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "regulation of ciliary cell motility" RELATED []
synonym: "regulation of cilium cell motility" EXACT []
is_a: GO:2000145 ! regulation of cell motility
relationship: regulates GO:0060285 ! cilium-dependent cell motility

[Term]
id: GO:1902020
name: negative regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie]
synonym: "negative regulation of ciliary cell motility" RELATED []
synonym: "negative regulation of cilium cell motility" EXACT []
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000146 ! negative regulation of cell motility
relationship: negatively_regulates GO:0060285 ! cilium-dependent cell motility

[Term]
id: GO:1902021
name: regulation of bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "regulation of bacterial-type flagellar cell motility" RELATED []
synonym: "regulation of bacterial-type flagellum cell motility" EXACT []
synonym: "regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
is_a: GO:2000145 ! regulation of cell motility
relationship: regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility

[Term]
id: GO:1902022
name: L-lysine transport
namespace: biological_process
def: "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:1902024
name: L-histidine transport
namespace: biological_process
def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015801 ! aromatic amino acid transport
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015817 ! histidine transport

[Term]
id: GO:1902025
name: nitrate import
namespace: biological_process
def: "The directed movement of nitrate into a cell or organelle." [GOC:TermGenie, PMID:22658680]
synonym: "nitrate influx" EXACT []
synonym: "nitrate uptake" EXACT []
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:1902026
name: regulation of cartilage condensation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0001502 ! cartilage condensation

[Term]
id: GO:1902027
name: positive regulation of cartilage condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865]
synonym: "activation of cartilage condensation" NARROW [GOC:TermGenie]
synonym: "up regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of cartilage condensation" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1902026 ! regulation of cartilage condensation
relationship: positively_regulates GO:0001502 ! cartilage condensation

[Term]
id: GO:1902028
name: obsolete regulation of histone H3-K18 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0043993

[Term]
id: GO:1902029
name: obsolete positive regulation of histone H3-K18 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "activation of histone H3-K18 acetylation" NARROW [GOC:TermGenie]
synonym: "activation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0043993

[Term]
id: GO:1902030
name: obsolete negative regulation of histone H3-K18 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K18 acetylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902031
name: regulation of NADP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NADP metabolic process." [GOC:TermGenie, PMID:23334421]
synonym: "regulation of NAD phosphorylation and dephosphorylation" RELATED [GOC:TermGenie]
synonym: "regulation of NADP (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NADP (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NADP (reduced) metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NADP (reduced) metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NADP metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NADPH metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NADPH metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NADP metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NADP metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of reduced NADP metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of reduced NADP metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
relationship: regulates GO:0006739 ! NADP metabolic process

[Term]
id: GO:1902032
name: obsolete regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in response to osmotic stress." [GOC:kmv, GOC:TermGenie, PMID:18636113]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "global transcription regulation from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in osmotic response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in osmotic stress response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic stress response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in response to osmotic stress" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0006357
consider: GO:0006970

[Term]
id: GO:1902033
name: regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0072091 ! regulation of stem cell proliferation
relationship: regulates GO:0071425 ! hematopoietic stem cell proliferation

[Term]
id: GO:1902034
name: negative regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:1903707 ! negative regulation of hemopoiesis
is_a: GO:2000647 ! negative regulation of stem cell proliferation
relationship: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation

[Term]
id: GO:1902035
name: positive regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:2000648 ! positive regulation of stem cell proliferation
relationship: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation

[Term]
id: GO:1902036
name: regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
relationship: regulates GO:0060218 ! hematopoietic stem cell differentiation

[Term]
id: GO:1902037
name: negative regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
relationship: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation

[Term]
id: GO:1902038
name: positive regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
relationship: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation

[Term]
id: GO:1902039
name: negative regulation of seed dormancy process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449]
synonym: "down regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "down regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "down-regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "down-regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "downregulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "downregulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "inhibition of seed dormancy" RELATED [GOC:TermGenie]
synonym: "inhibition of seed dormancy process" NARROW [GOC:TermGenie]
synonym: "negative regulation of seed dormancy" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000033 ! regulation of seed dormancy process
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0010162 ! seed dormancy process

[Term]
id: GO:1902040
name: positive regulation of seed dormancy process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449]
synonym: "activation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "activation of seed dormancy process" NARROW [GOC:TermGenie]
synonym: "positive regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "up regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "up regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "up-regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "up-regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "upregulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "upregulation of seed dormancy process" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000033 ! regulation of seed dormancy process
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0010162 ! seed dormancy process

[Term]
id: GO:1902041
name: regulation of extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
synonym: "regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
relationship: regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors

[Term]
id: GO:1902042
name: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
synonym: "down regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "down-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "downregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "inhibition of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie]
synonym: "negative regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors

[Term]
id: GO:1902043
name: positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
synonym: "activation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie]
synonym: "positive regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "up-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "upregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors

[Term]
id: GO:1902044
name: regulation of Fas signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429]
synonym: "regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0036337 ! Fas signaling pathway

[Term]
id: GO:1902045
name: negative regulation of Fas signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429]
synonym: "down regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Apo-1 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of CD95 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of Fas receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of FasR signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902044 ! regulation of Fas signaling pathway
relationship: negatively_regulates GO:0036337 ! Fas signaling pathway

[Term]
id: GO:1902046
name: positive regulation of Fas signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429]
synonym: "activation of Apo-1 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of CD95 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of Fas receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of FasR signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of FasR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902044 ! regulation of Fas signaling pathway
relationship: positively_regulates GO:0036337 ! Fas signaling pathway

[Term]
id: GO:1902047
name: polyamine transmembrane transport
namespace: biological_process
alt_id: GO:1905122
def: "The process in which a polyamine macromolecule is transported across a membrane." [GOC:TermGenie, GOC:vw]
synonym: "polyamine import" RELATED []
synonym: "polyamine uptake" RELATED [PMID:23205587]
is_a: GO:0015846 ! polyamine transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1902048
name: neosartoricin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "neosartoricin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1900619 ! acetate ester metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:1902049
name: neosartoricin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "neosartoricin breakdown" EXACT [GOC:TermGenie]
synonym: "neosartoricin catabolism" EXACT [GOC:TermGenie]
synonym: "neosartoricin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1902048 ! neosartoricin metabolic process

[Term]
id: GO:1902050
name: neosartoricin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1902048 ! neosartoricin metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:1902051
name: (25S)-Delta(4)-dafachronate binding
namespace: molecular_function
def: "Binding to (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:16529801]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:1990239 ! steroid hormone binding

[Term]
id: GO:1902052
name: (25S)-Delta(7)-dafachronate binding
namespace: molecular_function
def: "Binding to (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:16529801]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:1990239 ! steroid hormone binding

[Term]
id: GO:1902053
name: regulation of neosartoricin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:1902050 ! neosartoricin biosynthetic process

[Term]
id: GO:1902054
name: negative regulation of neosartoricin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "down regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:1902050 ! neosartoricin biosynthetic process

[Term]
id: GO:1902055
name: positive regulation of neosartoricin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "activation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of neosartoricin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "activation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
relationship: positively_regulates GO:1902050 ! neosartoricin biosynthetic process

[Term]
id: GO:1902056
name: (25S)-Delta(7)-dafachronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:22505847]
synonym: "(25S)-Delta(7)-dafachronate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1902057
name: (25S)-Delta(4)-dafachronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:20178781]
synonym: "(25S)-Delta(4)-dafachronate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:1902058
name: regulation of sporocarp development involved in sexual reproduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775]
synonym: "regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
is_a: GO:0031155 ! regulation of reproductive fruiting body development
relationship: regulates GO:0000909 ! sporocarp development involved in sexual reproduction

[Term]
id: GO:1902059
name: negative regulation of sporocarp development involved in sexual reproduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775]
synonym: "down regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "down regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "down regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "down-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "down-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "downregulation of ascus development" NARROW [GOC:TermGenie]
synonym: "downregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "downregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "downregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "downregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "inhibition of ascus development" NARROW [GOC:TermGenie]
synonym: "inhibition of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "inhibition of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "inhibition of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "inhibition of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie]
synonym: "negative regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "negative regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "negative regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "negative regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction
relationship: negatively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction

[Term]
id: GO:1902060
name: positive regulation of sporocarp development involved in sexual reproduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775]
synonym: "activation of ascus development" NARROW [GOC:TermGenie]
synonym: "activation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "activation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "activation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "activation of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie]
synonym: "positive regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "positive regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "positive regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "positive regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "up regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "up regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "up regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "up-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "up-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "upregulation of ascus development" NARROW [GOC:TermGenie]
synonym: "upregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "upregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "upregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "upregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction
relationship: positively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction

[Term]
id: GO:1902061
name: betaine aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483]
synonym: "betaine aldehyde metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1902062
name: betaine aldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483]
synonym: "betaine aldehyde breakdown" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde catabolism" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1902061 ! betaine aldehyde metabolic process

[Term]
id: GO:1902063
name: betaine aldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483]
synonym: "betaine aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde formation" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1902061 ! betaine aldehyde metabolic process

[Term]
id: GO:1902064
name: obsolete regulation of transcription from RNA polymerase II promoter involved in spermatogenesis
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in spermatogenesis." [GOC:kmv, GOC:TermGenie, PMID:22570621]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "global transcription regulation from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in spermatogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in spermatogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in spermatogenesis" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902065
name: response to L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1902066
name: regulation of cell wall pectin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell wall pectin metabolic process." [GOC:TermGenie, PMID:23453954]
synonym: "regulation of cell wall pectin metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cellulose and pectin-containing cell wall pectin metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of pectin metabolism during cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of plant-type cell wall pectin metabolic process" EXACT [GOC:TermGenie]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0052546 ! cell wall pectin metabolic process

[Term]
id: GO:1902068
name: regulation of sphingolipid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412]
synonym: "regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0090520 ! sphingolipid mediated signaling pathway

[Term]
id: GO:1902069
name: negative regulation of sphingolipid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412]
synonym: "down regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway
relationship: negatively_regulates GO:0090520 ! sphingolipid mediated signaling pathway

[Term]
id: GO:1902070
name: positive regulation of sphingolipid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412]
synonym: "activation of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway
relationship: positively_regulates GO:0090520 ! sphingolipid mediated signaling pathway

[Term]
id: GO:1902071
name: regulation of hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie]
synonym: "regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway

[Term]
id: GO:1902072
name: negative regulation of hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie]
synonym: "down regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:1900038 ! negative regulation of cellular response to hypoxia
is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
relationship: negatively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway

[Term]
id: GO:1902073
name: positive regulation of hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie, PMID:21685248]
synonym: "activation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "activation of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "hypoxic stabilization of HIF1A" NARROW []
synonym: "positive regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
relationship: positively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway

[Term]
id: GO:1902074
name: response to salt
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]
synonym: "response to salinity" NARROW [GOC:mls]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1902075
name: cellular response to salt
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]
synonym: "cellular response to salinity" NARROW [GOC:mls]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902074 ! response to salt

[Term]
id: GO:1902076
name: regulation of lateral motor column neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475]
is_a: GO:1905483 ! regulation of motor neuron migration
relationship: regulates GO:0097477 ! lateral motor column neuron migration

[Term]
id: GO:1902077
name: negative regulation of lateral motor column neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475]
synonym: "down regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "downregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "inhibition of lateral motor column neuron migration" NARROW [GOC:TermGenie]
is_a: GO:1902076 ! regulation of lateral motor column neuron migration
is_a: GO:1905484 ! negative regulation of motor neuron migration
relationship: negatively_regulates GO:0097477 ! lateral motor column neuron migration

[Term]
id: GO:1902078
name: positive regulation of lateral motor column neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475]
synonym: "activation of lateral motor column neuron migration" NARROW [GOC:TermGenie]
synonym: "up regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "upregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
is_a: GO:1902076 ! regulation of lateral motor column neuron migration
is_a: GO:1905485 ! positive regulation of motor neuron migration
relationship: positively_regulates GO:0097477 ! lateral motor column neuron migration

[Term]
id: GO:1902079
name: D-valine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-valine." [GOC:TermGenie, PMID:23085840]
synonym: "D-valine breakdown" EXACT [GOC:TermGenie]
synonym: "D-valine catabolism" EXACT [GOC:TermGenie]
synonym: "D-valine degradation" EXACT [GOC:TermGenie]
is_a: GO:0006574 ! valine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:1902114 ! D-valine metabolic process

[Term]
id: GO:1902080
name: regulation of calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum

[Term]
id: GO:1902081
name: negative regulation of calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]
synonym: "down regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum
relationship: negatively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum

[Term]
id: GO:1902082
name: positive regulation of calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]
synonym: "activation of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum
relationship: positively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum

[Term]
id: GO:1902083
name: negative regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19198614]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down regulation of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-cysteine S-nitrosylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "inhibition of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of S-nitrosylation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation
relationship: negatively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation

[Term]
id: GO:1902084
name: fumagillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "fumagillin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0097176 ! epoxide metabolic process

[Term]
id: GO:1902085
name: fumagillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "fumagillin breakdown" EXACT [GOC:TermGenie]
synonym: "fumagillin catabolism" EXACT [GOC:TermGenie]
synonym: "fumagillin degradation" EXACT [GOC:TermGenie]
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1902084 ! fumagillin metabolic process

[Term]
id: GO:1902086
name: fumagillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumagillin formation" EXACT [GOC:TermGenie]
synonym: "fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902084 ! fumagillin metabolic process

[Term]
id: GO:1902087
name: dimethylsulfoniopropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S,S-dimethyl-beta-propiothetin." [GOC:jh2, GOC:TermGenie, PMID:19807777]
synonym: "S,S-dimethyl-beta-propiothetin breakdown" EXACT [GOC:TermGenie]
synonym: "S,S-dimethyl-beta-propiothetin catabolic process" EXACT []
synonym: "S,S-dimethyl-beta-propiothetin catabolism" EXACT [GOC:TermGenie]
synonym: "S,S-dimethyl-beta-propiothetin degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:1902088
name: plant-type cell wall loosening involved in abscission
namespace: biological_process
def: "Any plant-type cell wall loosening that is involved in abscission." [GOC:TermGenie, PMID:23479623]
synonym: "cellulose and pectin-containing cell wall loosening involved in abscission" EXACT [GOC:TermGenie]
is_a: GO:0009828 ! plant-type cell wall loosening
is_a: GO:0009830 ! cell wall modification involved in abscission

[Term]
id: GO:1902089
name: cell wall polysaccharide catabolic process involved in lateral root development
namespace: biological_process
def: "Any cell wall polysaccharide catabolic process that is involved in lateral root development." [GOC:TermGenie, PMID:23479623]
synonym: "cell wall polysaccharide breakdown involved in lateral root development" EXACT [GOC:TermGenie]
is_a: GO:0044347 ! cell wall polysaccharide catabolic process
relationship: part_of GO:0048527 ! lateral root development

[Term]
id: GO:1902090
name: regulation of fumagillin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:1902086 ! fumagillin biosynthetic process

[Term]
id: GO:1902091
name: negative regulation of fumagillin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "down regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1902090 ! regulation of fumagillin biosynthetic process
relationship: negatively_regulates GO:1902086 ! fumagillin biosynthetic process

[Term]
id: GO:1902092
name: positive regulation of fumagillin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "activation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of fumagillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "activation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1902090 ! regulation of fumagillin biosynthetic process
relationship: positively_regulates GO:1902086 ! fumagillin biosynthetic process

[Term]
id: GO:1902093
name: positive regulation of flagellated sperm motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657]
synonym: "activation of sperm motility" NARROW [GOC:TermGenie]
synonym: "activation of sperm movement" BROAD [GOC:TermGenie]
synonym: "positive regulation of sperm motility" BROAD []
synonym: "positive regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "up regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "up regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie]
is_a: GO:0003353 ! positive regulation of cilium movement
is_a: GO:1901317 ! regulation of flagellated sperm motility
is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0030317 ! flagellated sperm motility

[Term]
id: GO:1902097
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium." [GOC:kmv, GOC:TermGenie, PMID:17183709]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0045944
consider: GO:0050829

[Term]
id: GO:1902098
name: calcitriol binding
namespace: molecular_function
def: "Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3." [GOC:TermGenie, PMID:21872797, Wikipedia:Calcitriol_receptor]
synonym: "1,25-dihydroxycholecalciferol binding" EXACT [Wikipedia:Calcitriol]
synonym: "1,25-dihydroxyvitamin D3 binding" EXACT [Wikipedia:Calcitriol]
synonym: "1alpha,25(OH)2 vitamin D3 binding" EXACT [PMID:21872797]
synonym: "1alpha,25(OH)2D3 binding" EXACT [CHEBI:17823]
synonym: "1alpha,25-dihydroxycholecalciferol binding" EXACT [CHEBI:17823]
synonym: "1alpha,25-dihydroxyvitamin D3 binding" EXACT [CHEBI:17823]
synonym: "hormonally active vitamin D3 binding" EXACT [GOC:bf]
is_a: GO:1902271 ! D3 vitamins binding

[Term]
id: GO:1902099
name: regulation of metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:1901987 ! regulation of cell cycle phase transition
relationship: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle

[Term]
id: GO:1902100
name: negative regulation of metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "inhibition of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie]
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
relationship: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle

[Term]
id: GO:1902101
name: positive regulation of metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie]
synonym: "up regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
relationship: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle

[Term]
id: GO:1902102
name: regulation of metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
is_a: GO:1905132 ! regulation of meiotic chromosome separation
relationship: regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle

[Term]
id: GO:1902103
name: negative regulation of metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "down regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie]
synonym: "negative regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition
is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle
is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905133 ! negative regulation of meiotic chromosome separation
relationship: negatively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle

[Term]
id: GO:1902104
name: positive regulation of metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "activation of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie]
synonym: "positive regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "up regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "up regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition
is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle
is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905134 ! positive regulation of meiotic chromosome separation
relationship: positively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle

[Term]
id: GO:1902105
name: regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1903706 ! regulation of hemopoiesis
relationship: regulates GO:0002521 ! leukocyte differentiation

[Term]
id: GO:1902106
name: negative regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903707 ! negative regulation of hemopoiesis
relationship: negatively_regulates GO:0002521 ! leukocyte differentiation

[Term]
id: GO:1902107
name: positive regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903708 ! positive regulation of hemopoiesis
relationship: positively_regulates GO:0002521 ! leukocyte differentiation

[Term]
id: GO:1902108
name: regulation of mitochondrial membrane permeability involved in apoptotic process
namespace: biological_process
def: "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]
synonym: "regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0008637 ! apoptotic mitochondrial changes
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability

[Term]
id: GO:1902109
name: negative regulation of mitochondrial membrane permeability involved in apoptotic process
namespace: biological_process
def: "Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]
synonym: "mitochondrial membrane impermeability involved in apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic process" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic program" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic programmed cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in programmed cell death by apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in type I programmed cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0035795 ! negative regulation of mitochondrial membrane permeability
is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process

[Term]
id: GO:1902110
name: positive regulation of mitochondrial membrane permeability involved in apoptotic process
namespace: biological_process
def: "Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]
comment: Individual components of the mitochondrial permeability transition pore complex, such as the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D), are involved in this process.
synonym: "mitochondrial membrane permeability transition involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process
is_a: GO:1902686 ! mitochondrial outer membrane permeabilization involved in programmed cell death

[Term]
id: GO:1902111
name: response to diethyl maleate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1902112
name: cellular response to diethyl maleate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902111 ! response to diethyl maleate

[Term]
id: GO:1902113
name: obsolete nucleotide phosphorylation involved in DNA repair
namespace: biological_process
def: "OBSOLETE. Any nucleotide phosphorylation that is involved in DNA repair." [GOC:TermGenie, PMID:11729194]
comment: The reason for obsoletion is that this term represents a single step MF.
is_obsolete: true

[Term]
id: GO:1902114
name: D-valine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-valine." [GOC:TermGenie, PMID:23085840]
synonym: "D-valine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:1902115
name: regulation of organelle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0070925 ! organelle assembly

[Term]
id: GO:1902116
name: negative regulation of organelle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1902115 ! regulation of organelle assembly
relationship: negatively_regulates GO:0070925 ! organelle assembly

[Term]
id: GO:1902117
name: positive regulation of organelle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "activation of organelle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1902115 ! regulation of organelle assembly
relationship: positively_regulates GO:0070925 ! organelle assembly

[Term]
id: GO:1902118
name: calcidiol binding
namespace: molecular_function
def: "Binding to calcidiol." [GOC:bf, GOC:TermGenie, PMID:11799400]
synonym: "25(OH)D3 binding" EXACT [CHEBI:17933]
synonym: "25-hydroxycholecalciferol binding" EXACT [CHEBI:17933]
synonym: "25-hydroxyvitamin D3 binding" EXACT [CHEBI:17933]
synonym: "25OHD3 binding" EXACT [PMID:11799400]
synonym: "calcifediol binding" EXACT [CHEBI:17933]
is_a: GO:1902271 ! D3 vitamins binding

[Term]
id: GO:1902119
name: regulation of meiotic spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392]
synonym: "regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
is_a: GO:0032887 ! regulation of spindle elongation
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0051232 ! meiotic spindle elongation

[Term]
id: GO:1902120
name: negative regulation of meiotic spindle elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392]
synonym: "down regulation of meiotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic spindle elongation" NARROW [GOC:TermGenie]
synonym: "inhibition of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
is_a: GO:1902119 ! regulation of meiotic spindle elongation
relationship: negatively_regulates GO:0051232 ! meiotic spindle elongation

[Term]
id: GO:1902121
name: lithocholic acid binding
namespace: molecular_function
def: "Binding to lithocholic acid." [GOC:bf, GOC:TermGenie, PMID:20371703]
synonym: "LCA binding" EXACT [PMID:20371703]
is_a: GO:0005496 ! steroid binding
is_a: GO:0032052 ! bile acid binding

[Term]
id: GO:1902122
name: chenodeoxycholic acid binding
namespace: molecular_function
def: "Binding to chenodeoxycholic acid." [GOC:bf, GOC:TermGenie, PMID:10334992]
synonym: "CDCA binding" EXACT [CHEBI:16755]
is_a: GO:0005496 ! steroid binding
is_a: GO:0032052 ! bile acid binding

[Term]
id: GO:1902123
name: (-)-pinoresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-pinoresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995]
synonym: "(-)-pinoresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901598 ! (-)-pinoresinol metabolic process

[Term]
id: GO:1902124
name: (+)-pinoresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-pinoresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:1902125
name: (+)-pinoresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-pinoresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1902124 ! (+)-pinoresinol metabolic process

[Term]
id: GO:1902126
name: (+)-pinoresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-pinoresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902124 ! (+)-pinoresinol metabolic process

[Term]
id: GO:1902127
name: (-)-lariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-lariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995]
synonym: "(-)-lariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:1902128
name: (-)-lariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-lariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995]
synonym: "(-)-lariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1902127 ! (-)-lariciresinol metabolic process

[Term]
id: GO:1902129
name: (-)-lariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-lariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995]
synonym: "(-)-lariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1902127 ! (-)-lariciresinol metabolic process

[Term]
id: GO:1902130
name: (+)-lariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-lariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:1902131
name: (+)-lariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-lariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1902130 ! (+)-lariciresinol metabolic process

[Term]
id: GO:1902132
name: (+)-lariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-lariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902130 ! (+)-lariciresinol metabolic process

[Term]
id: GO:1902133
name: (+)-secoisolariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-secoisolariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995]
synonym: "(+)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:1902134
name: (+)-secoisolariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-secoisolariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995]
synonym: "(+)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process

[Term]
id: GO:1902135
name: (+)-secoisolariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-secoisolariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995]
synonym: "(+)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process

[Term]
id: GO:1902136
name: (-)-secoisolariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(-)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:1902137
name: (-)-secoisolariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(-)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process

[Term]
id: GO:1902138
name: (-)-secoisolariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(-)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process

[Term]
id: GO:1902140
name: response to inositol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1902141
name: cellular response to inositol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902140 ! response to inositol

[Term]
id: GO:1902145
name: regulation of response to cell cycle checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0072396 ! response to cell cycle checkpoint signaling

[Term]
id: GO:1902146
name: positive regulation of response to cell cycle checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "activation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "activation of response to cell cycle checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "activation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "activation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "activation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "activation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "positive regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up-regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "upregulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "upregulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "upregulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "upregulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling
relationship: positively_regulates GO:0072396 ! response to cell cycle checkpoint signaling

[Term]
id: GO:1902147
name: regulation of response to cytokinesis checkpoint signaling
namespace: biological_process
alt_id: GO:1902149
def: "Any process that modulates the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling
relationship: regulates GO:0072399 ! response to cytokinesis checkpoint signaling

[Term]
id: GO:1902148
name: positive regulation of response to cytokinesis checkpoint signaling
namespace: biological_process
alt_id: GO:1902150
def: "Any process that activates or increases the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to cytokinesis checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling
is_a: GO:1902147 ! regulation of response to cytokinesis checkpoint signaling
relationship: positively_regulates GO:0072399 ! response to cytokinesis checkpoint signaling

[Term]
id: GO:1902151
name: regulation of response to DNA integrity checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling
relationship: regulates GO:0072402 ! response to DNA integrity checkpoint signaling

[Term]
id: GO:1902152
name: positive regulation of response to DNA integrity checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to DNA integrity checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling
is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling
relationship: positively_regulates GO:0072402 ! response to DNA integrity checkpoint signaling

[Term]
id: GO:1902153
name: regulation of response to DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling
relationship: regulates GO:0072423 ! response to DNA damage checkpoint signaling

[Term]
id: GO:1902154
name: positive regulation of response to DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to DNA damage checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902152 ! positive regulation of response to DNA integrity checkpoint signaling
is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling
relationship: positively_regulates GO:0072423 ! response to DNA damage checkpoint signaling

[Term]
id: GO:1902155
name: regulation of response to G1 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling
relationship: regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling

[Term]
id: GO:1902156
name: positive regulation of response to G1 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to G1 DNA damage checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "activation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling
is_a: GO:1902155 ! regulation of response to G1 DNA damage checkpoint signaling
relationship: positively_regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling

[Term]
id: GO:1902157
name: regulation of response to G2 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling
relationship: regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling

[Term]
id: GO:1902158
name: positive regulation of response to G2 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to G2 DNA damage checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling
is_a: GO:1902157 ! regulation of response to G2 DNA damage checkpoint signaling
relationship: positively_regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling

[Term]
id: GO:1902159
name: regulation of cyclic nucleotide-gated ion channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311]
subset: gocheck_obsoletion_candidate
synonym: "regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity

[Term]
id: GO:1902160
name: obsolete negative regulation of cyclic nucleotide-gated ion channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902161
name: positive regulation of cyclic nucleotide-gated ion channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311]
subset: gocheck_obsoletion_candidate
synonym: "activation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity

[Term]
id: GO:1902162
name: obsolete regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, PMID:17719541]
comment: The reason for obsoletion is that this term is about down stream effects, not the signaling pathway itself.
is_obsolete: true
replaced_by: GO:0043516

[Term]
id: GO:1902163
name: obsolete negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, PMID:17719541]
comment: The reason for obsoletion is that this term is about down stream effects, not the signaling pathway itself.
synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0043518

[Term]
id: GO:1902164
name: obsolete positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, PMID:17719541]
comment: The reason for obsoletion is that this term is about down stream effects, not the signaling pathway itself.
synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0043517

[Term]
id: GO:1902165
name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]
synonym: "regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
relationship: regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

[Term]
id: GO:1902166
name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]
synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
is_a: GO:1902230 ! negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
relationship: negatively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

[Term]
id: GO:1902167
name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]
synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
is_a: GO:1902231 ! positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
relationship: positively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

[Term]
id: GO:1902168
name: response to catechin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620]
is_a: GO:0080184 ! response to phenylpropanoid
is_a: GO:1905395 ! response to flavonoid

[Term]
id: GO:1902169
name: cellular response to catechin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620]
is_a: GO:1902168 ! response to catechin
is_a: GO:1905396 ! cellular response to flavonoid
is_a: GO:1905546 ! cellular response to phenylpropanoid

[Term]
id: GO:1902170
name: cellular response to reactive nitrogen species
namespace: biological_process
alt_id: GO:1990106
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus." [GOC:sl, GOC:TermGenie, PMID:22504638]
is_a: GO:1901699 ! cellular response to nitrogen compound

[Term]
id: GO:1902171
name: regulation of tocopherol cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tocopherol cyclase activity." [GOC:TermGenie, PMID:23632854]
subset: gocheck_obsoletion_candidate
is_a: GO:0031279 ! regulation of cyclase activity

[Term]
id: GO:1902172
name: regulation of keratinocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]
synonym: "regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: regulates GO:0097283 ! keratinocyte apoptotic process

[Term]
id: GO:1902173
name: negative regulation of keratinocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]
synonym: "down regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of keratinocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1902172 ! regulation of keratinocyte apoptotic process
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
relationship: negatively_regulates GO:0097283 ! keratinocyte apoptotic process

[Term]
id: GO:1902174
name: positive regulation of keratinocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]
synonym: "activation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of keratinocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1902172 ! regulation of keratinocyte apoptotic process
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
relationship: positively_regulates GO:0097283 ! keratinocyte apoptotic process

[Term]
id: GO:1902175
name: regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf]
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress

[Term]
id: GO:1902176
name: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf]
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress

[Term]
id: GO:1902177
name: positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
synonym: "activation of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress

[Term]
id: GO:1902178
name: fibroblast growth factor receptor apoptotic signaling pathway
namespace: biological_process
def: "An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR)." [GOC:mtg_apoptosis, GOC:pm, GOC:pr, GOC:TermGenie, PMID:17561467]
synonym: "FGF receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic process" EXACT [GOC:pm]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:1902179
name: verruculogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274]
synonym: "verruculogen metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0035834 ! indole alkaloid metabolic process

[Term]
id: GO:1902180
name: obsolete verruculogen catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "verruculogen breakdown" EXACT [GOC:TermGenie]
synonym: "verruculogen catabolism" EXACT [GOC:TermGenie]
synonym: "verruculogen degradation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902181
name: verruculogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274]
synonym: "verruculogen anabolism" EXACT [GOC:TermGenie]
synonym: "verruculogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "verruculogen formation" EXACT [GOC:TermGenie]
synonym: "verruculogen synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902179 ! verruculogen metabolic process

[Term]
id: GO:1902182
name: shoot apical meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure." [GOC:TermGenie, PMID:21496644]
synonym: "primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "promeristem development" BROAD [GOC:TermGenie]
synonym: "SAM development" EXACT [GOC:TermGenie]
is_a: GO:0048507 ! meristem development

[Term]
id: GO:1902183
name: regulation of shoot apical meristem development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644]
synonym: "regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "regulation of SAM development" EXACT [GOC:TermGenie]
is_a: GO:0048509 ! regulation of meristem development
relationship: regulates GO:1902182 ! shoot apical meristem development

[Term]
id: GO:1902184
name: negative regulation of shoot apical meristem development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644]
synonym: "down regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "down regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "down regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "down regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "down-regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "down-regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "down-regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "down-regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "downregulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "downregulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "downregulation of SAM development" EXACT [GOC:TermGenie]
synonym: "downregulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "inhibition of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "inhibition of promeristem development" BROAD [GOC:TermGenie]
synonym: "inhibition of SAM development" EXACT [GOC:TermGenie]
synonym: "inhibition of shoot apical meristem development" NARROW [GOC:TermGenie]
synonym: "negative regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "negative regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "negative regulation of SAM development" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902183 ! regulation of shoot apical meristem development
relationship: negatively_regulates GO:1902182 ! shoot apical meristem development

[Term]
id: GO:1902185
name: positive regulation of shoot apical meristem development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644]
synonym: "activation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "activation of promeristem development" BROAD [GOC:TermGenie]
synonym: "activation of SAM development" EXACT [GOC:TermGenie]
synonym: "activation of shoot apical meristem development" NARROW [GOC:TermGenie]
synonym: "positive regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "positive regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "positive regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "up regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "up regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "up regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "up regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "up-regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "up-regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "up-regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "up-regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "upregulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "upregulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "upregulation of SAM development" EXACT [GOC:TermGenie]
synonym: "upregulation of shoot apical meristem development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902183 ! regulation of shoot apical meristem development
relationship: positively_regulates GO:1902182 ! shoot apical meristem development

[Term]
id: GO:1902186
name: obsolete regulation of viral release from host cell
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167]
comment: This term was obsoleted because there is no evidence that it is a regulated process.
synonym: "regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "regulation of viral release" EXACT [GOC:TermGenie]
synonym: "regulation of viral shedding" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0019076

[Term]
id: GO:1902188
name: obsolete positive regulation of viral release from host cell
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167]
comment: This term was obsoleted because there is no evidence that it is a regulated process.
synonym: "activation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "activation of viral exit" EXACT [GOC:TermGenie]
synonym: "activation of viral release" EXACT [GOC:TermGenie]
synonym: "activation of viral release from host cell" NARROW [GOC:TermGenie]
synonym: "activation of viral shedding" EXACT [GOC:TermGenie]
synonym: "positive regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral release" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "up regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "up regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "up regulation of viral release" EXACT [GOC:TermGenie]
synonym: "up regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "up-regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral release" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "upregulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "upregulation of viral exit" EXACT [GOC:TermGenie]
synonym: "upregulation of viral release" EXACT [GOC:TermGenie]
synonym: "upregulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of viral shedding" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0019076

[Term]
id: GO:1902189
name: 2-methylbutanoyl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432]
synonym: "2-methylbutanoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:1902190
name: 2-methylbutanoyl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432]
synonym: "2-methylbutanoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process

[Term]
id: GO:1902191
name: 2-methylbutanoyl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432]
synonym: "2-methylbutanoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process

[Term]
id: GO:1902192
name: 2-methylbut-2-enoyl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432]
synonym: "2-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:1902193
name: 2-methylbut-2-enoyl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432]
synonym: "2-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process

[Term]
id: GO:1902194
name: 2-methylbut-2-enoyl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432]
synonym: "2-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process

[Term]
id: GO:1902195
name: isovaleryl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isovaleryl-CoA(4-)." [GOC:TermGenie, PMID:11231285]
synonym: "isovaleryl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:1902196
name: isovaleryl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isovaleryl-CoA(4-)." [GOC:TermGenie, PMID:11231285]
synonym: "isovaleryl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process

[Term]
id: GO:1902197
name: isovaleryl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isovaleryl-CoA(4-)." [GOC:TermGenie, PMID:11231285]
synonym: "isovaleryl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process

[Term]
id: GO:1902198
name: 3-methylbut-2-enoyl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:11231285]
synonym: "3-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:1902199
name: 3-methylbut-2-enoyl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:11231285]
synonym: "3-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process

[Term]
id: GO:1902200
name: 3-methylbut-2-enoyl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:11231285]
synonym: "3-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process

[Term]
id: GO:1902201
name: negative regulation of bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "down regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "down regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "inhibition of bacterial-type flagellar cell motility" NARROW [GOC:TermGenie]
synonym: "inhibition of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "negative regulation of bacterial-type flagellar cell motility" RELATED []
synonym: "negative regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility
is_a: GO:2000146 ! negative regulation of cell motility
relationship: negatively_regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility

[Term]
id: GO:1902202
name: regulation of hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921]
synonym: "regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of Met signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway

[Term]
id: GO:1902203
name: negative regulation of hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921]
synonym: "down regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Met signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway

[Term]
id: GO:1902204
name: positive regulation of hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921]
synonym: "activation of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "activation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Met signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway
relationship: positively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway

[Term]
id: GO:1902205
name: regulation of interleukin-2-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529]
synonym: "regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0038110 ! interleukin-2-mediated signaling pathway

[Term]
id: GO:1902206
name: negative regulation of interleukin-2-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529]
synonym: "down regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway
relationship: negatively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway

[Term]
id: GO:1902207
name: positive regulation of interleukin-2-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529]
synonym: "activation of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway
relationship: positively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway

[Term]
id: GO:1902208
name: regulation of bacterial-type flagellum assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie]
synonym: "regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
is_a: GO:0060491 ! regulation of cell projection assembly
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0044780 ! bacterial-type flagellum assembly

[Term]
id: GO:1902209
name: negative regulation of bacterial-type flagellum assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie]
synonym: "down regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of bacterial flagellum assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of bacterial-type flagellum assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly
relationship: negatively_regulates GO:0044780 ! bacterial-type flagellum assembly

[Term]
id: GO:1902210
name: positive regulation of bacterial-type flagellum assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie]
synonym: "activation of bacterial flagellum assembly" NARROW [GOC:TermGenie]
synonym: "activation of bacterial-type flagellum assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly
relationship: positively_regulates GO:0044780 ! bacterial-type flagellum assembly

[Term]
id: GO:1902211
name: regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0038161 ! prolactin signaling pathway

[Term]
id: GO:1902212
name: negative regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "down regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of PRL signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of prolactin signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902211 ! regulation of prolactin signaling pathway
relationship: negatively_regulates GO:0038161 ! prolactin signaling pathway

[Term]
id: GO:1902213
name: positive regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "activation of PRL signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of prolactin signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902211 ! regulation of prolactin signaling pathway
relationship: positively_regulates GO:0038161 ! prolactin signaling pathway

[Term]
id: GO:1902214
name: regulation of interleukin-4-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636]
synonym: "regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0035771 ! interleukin-4-mediated signaling pathway

[Term]
id: GO:1902215
name: negative regulation of interleukin-4-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636]
synonym: "down regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway
relationship: negatively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway

[Term]
id: GO:1902216
name: positive regulation of interleukin-4-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636]
synonym: "activation of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway
relationship: positively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway

[Term]
id: GO:1902217
name: erythrocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:1902218
name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
is_a: GO:0106049 ! regulation of cellular response to osmotic stress
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress

[Term]
id: GO:1902219
name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie]
is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress

[Term]
id: GO:1902220
name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress

[Term]
id: GO:1902221
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process

[Term]
id: GO:1902222
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid breakdown" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolism" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

[Term]
id: GO:1902223
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid anabolism" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid formation" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

[Term]
id: GO:1902224
name: ketone body metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie]
synonym: "ketone body metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:1902225
name: negative regulation of acrosome reaction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction." [GOC:TermGenie, PMID:23430248]
synonym: "down regulation of acrosome reaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of acrosome reaction" EXACT [GOC:TermGenie]
synonym: "downregulation of acrosome reaction" EXACT [GOC:TermGenie]
synonym: "inhibition of acrosome reaction" NARROW [GOC:TermGenie]
is_a: GO:0060046 ! regulation of acrosome reaction
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0007340 ! acrosome reaction

[Term]
id: GO:1902226
name: regulation of macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167]
synonym: "regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus
relationship: regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway

[Term]
id: GO:1902227
name: negative regulation of macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167]
synonym: "down regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of M-CSF signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway
relationship: negatively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway

[Term]
id: GO:1902228
name: positive regulation of macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167]
synonym: "activation of M-CSF signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway
relationship: positively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway

[Term]
id: GO:1902229
name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]
synonym: "regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage

[Term]
id: GO:1902230
name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]
synonym: "down regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage

[Term]
id: GO:1902231
name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]
synonym: "activation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage

[Term]
id: GO:1902232
name: regulation of positive thymic T cell selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863]
synonym: "regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
is_a: GO:0033081 ! regulation of T cell differentiation in thymus
relationship: regulates GO:0045059 ! positive thymic T cell selection

[Term]
id: GO:1902233
name: negative regulation of positive thymic T cell selection
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863]
synonym: "down regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "down regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "down regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "down regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "inhibition of positive thymic T cell selection" NARROW [GOC:TermGenie]
synonym: "inhibition of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "inhibition of positive thymic T-cell selection" NARROW [GOC:TermGenie]
synonym: "inhibition of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "negative regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "negative regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "negative regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus
is_a: GO:1902232 ! regulation of positive thymic T cell selection
relationship: negatively_regulates GO:0045059 ! positive thymic T cell selection

[Term]
id: GO:1902234
name: positive regulation of positive thymic T cell selection
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863]
synonym: "activation of positive thymic T cell selection" NARROW [GOC:TermGenie]
synonym: "activation of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "activation of positive thymic T-cell selection" NARROW [GOC:TermGenie]
synonym: "activation of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "positive regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "positive regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "positive regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
is_a: GO:0033089 ! positive regulation of T cell differentiation in thymus
is_a: GO:1902232 ! regulation of positive thymic T cell selection
relationship: positively_regulates GO:0045059 ! positive thymic T cell selection

[Term]
id: GO:1902235
name: regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]
synonym: "regulation of apoptosis in response to endoplasmic reticulum stress" BROAD [GOC:TermGenie]
synonym: "regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

[Term]
id: GO:1902236
name: negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]
synonym: "down regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosis in response to ER stress" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis triggered by ER stress" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of ER stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "negative regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

[Term]
id: GO:1902237
name: positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]
synonym: "activation of apoptosis in response to ER stress" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis triggered by ER stress" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of ER stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "positive regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

[Term]
id: GO:1902238
name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]
is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
relationship: regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

[Term]
id: GO:1902239
name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie]
is_a: GO:1902219 ! negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
relationship: negatively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

[Term]
id: GO:1902240
name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]
synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
is_a: GO:1902220 ! positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
relationship: positively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

[Term]
id: GO:1902241
name: copal-8-ol diphosphate(3-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving copal-8-ol diphosphate(3-)." [GOC:TermGenie, PMID:22672125]
synonym: "copal-8-ol diphosphate(3-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0016101 ! diterpenoid metabolic process

[Term]
id: GO:1902242
name: copal-8-ol diphosphate(3-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of copal-8-ol diphosphate(3-)." [GOC:TermGenie, PMID:22672125]
synonym: "copal-8-ol diphosphate(3-) breakdown" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) catabolism" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process

[Term]
id: GO:1902243
name: copal-8-ol diphosphate(3-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of copal-8-ol diphosphate(3-)." [GOC:TermGenie, PMID:22672125]
synonym: "copal-8-ol diphosphate(3-) anabolism" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) formation" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process

[Term]
id: GO:1902244
name: cis-abienol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cis-abienol." [GOC:TermGenie, PMID:22672125]
synonym: "cis-abienol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:1902245
name: cis-abienol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cis-abienol." [GOC:TermGenie, PMID:22672125]
synonym: "cis-abienol breakdown" EXACT [GOC:TermGenie]
synonym: "cis-abienol catabolism" EXACT [GOC:TermGenie]
synonym: "cis-abienol degradation" EXACT [GOC:TermGenie]
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1902244 ! cis-abienol metabolic process

[Term]
id: GO:1902246
name: cis-abienol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cis-abienol." [GOC:TermGenie, PMID:22672125]
synonym: "cis-abienol anabolism" EXACT [GOC:TermGenie]
synonym: "cis-abienol biosynthesis" EXACT [GOC:TermGenie]
synonym: "cis-abienol formation" EXACT [GOC:TermGenie]
synonym: "cis-abienol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:1902244 ! cis-abienol metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:1902247
name: geranylgeranyl diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of geranylgeranyl diphosphate." [GOC:TermGenie, PMID:22672125]
synonym: "geranylgeranyl diphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "geranylgeranyl diphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "geranylgeranyl diphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016115 ! terpenoid catabolic process
is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process

[Term]
id: GO:1902248
name: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding
namespace: molecular_function
def: "Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate." [GOC:mah, GOC:TermGenie, PMID:4314233]
synonym: "5-phosphoribose 1-diphosphate binding" EXACT []
synonym: "phosphoribosylpyrophosphate binding" EXACT [GOC:al]
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:1902249
name: IMP binding
namespace: molecular_function
def: "Binding to IMP, inosine monophosphate." [GOC:mah, GOC:TermGenie, PMID:4314233]
is_a: GO:0032555 ! purine ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:1902250
name: regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
relationship: regulates GO:1902217 ! erythrocyte apoptotic process

[Term]
id: GO:1902251
name: negative regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
relationship: negatively_regulates GO:1902217 ! erythrocyte apoptotic process

[Term]
id: GO:1902252
name: positive regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
relationship: positively_regulates GO:1902217 ! erythrocyte apoptotic process

[Term]
id: GO:1902253
name: regulation of intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]
synonym: "regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator

[Term]
id: GO:1902254
name: negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]
synonym: "down regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "inhibition of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "negative regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator

[Term]
id: GO:1902255
name: positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]
synonym: "activation of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "activation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "positive regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator

[Term]
id: GO:1902256
name: regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
relationship: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis

[Term]
id: GO:1902257
name: negative regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis
relationship: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis

[Term]
id: GO:1902258
name: positive regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
relationship: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis

[Term]
id: GO:1902259
name: regulation of delayed rectifier potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]
subset: gocheck_obsoletion_candidate
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1902260
name: negative regulation of delayed rectifier potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11299204]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie]
is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity
is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity

[Term]
id: GO:1902261
name: positive regulation of delayed rectifier potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]
subset: gocheck_obsoletion_candidate
synonym: "activation of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity
is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity

[Term]
id: GO:1902262
name: apoptotic process involved in blood vessel morphogenesis
namespace: biological_process
def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358]
synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:1902263
name: apoptotic process involved in embryonic digit morphogenesis
namespace: biological_process
def: "Any apoptotic process that is involved in embryonic digit morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:15967824]
synonym: "apoptosis involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in embryonic digit morphogenesis" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
relationship: part_of GO:0042733 ! embryonic digit morphogenesis

[Term]
id: GO:1902265
name: abscisic acid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of abscisic acid within an organism or cell." [GOC:TermGenie, PMID:23252460]
synonym: "2-cis-abscisate homeostasis" RELATED []
synonym: "ABA homeostasis" RELATED []
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:1902266
name: intracellular abscisic acid homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a steady state level of abscisic acid within a cell." [GOC:TermGenie, PMID:23252460]
synonym: "cellular 2-cis-abscisate homeostasis" EXACT []
synonym: "cellular ABA homeostasis" RELATED []
is_a: GO:0055082 ! intracellular chemical homeostasis
is_a: GO:1902265 ! abscisic acid homeostasis

[Term]
id: GO:1902267
name: regulation of polyamine transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272]
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:1902047 ! polyamine transmembrane transport

[Term]
id: GO:1902268
name: negative regulation of polyamine transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "down regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of polyamine transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1902267 ! regulation of polyamine transmembrane transport
relationship: negatively_regulates GO:1902047 ! polyamine transmembrane transport

[Term]
id: GO:1902269
name: positive regulation of polyamine transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "activation of polyamine transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1902267 ! regulation of polyamine transmembrane transport
relationship: positively_regulates GO:1902047 ! polyamine transmembrane transport

[Term]
id: GO:1902270
name: (R)-carnitine transmembrane transport
namespace: biological_process
def: "The process in which (R)-carnitine is transported across a membrane." [GOC:TermGenie, PMID:23755272]
is_a: GO:1900749 ! (R)-carnitine transport
is_a: GO:1902603 ! carnitine transmembrane transport

[Term]
id: GO:1902271
name: D3 vitamins binding
namespace: molecular_function
def: "Binding to D3 vitamins." [GOC:bf, GOC:TermGenie, PMID:9127467]
is_a: GO:0005499 ! vitamin D binding

[Term]
id: GO:1902272
name: regulation of (R)-carnitine transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272]
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:1902270 ! (R)-carnitine transmembrane transport

[Term]
id: GO:1902273
name: negative regulation of (R)-carnitine transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "down regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport
relationship: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport

[Term]
id: GO:1902274
name: positive regulation of (R)-carnitine transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "activation of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport
relationship: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport

[Term]
id: GO:1902275
name: regulation of chromatin organization
namespace: biological_process
alt_id: GO:0001672
alt_id: GO:1903308
def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]
synonym: "regulation of chromatin assembly or disassembly" RELATED []
synonym: "regulation of chromatin assembly/disassembly" RELATED []
synonym: "regulation of chromatin modification" RELATED []
synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0006325 ! chromatin organization

[Term]
id: GO:1902276
name: regulation of pancreatic amylase secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie]
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0036395 ! pancreatic amylase secretion

[Term]
id: GO:1902277
name: negative regulation of pancreatic amylase secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie]
synonym: "down regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of pancreatic amylase secretion" NARROW [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:1902276 ! regulation of pancreatic amylase secretion
relationship: negatively_regulates GO:0036395 ! pancreatic amylase secretion

[Term]
id: GO:1902278
name: positive regulation of pancreatic amylase secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687]
synonym: "activation of pancreatic amylase secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:1902276 ! regulation of pancreatic amylase secretion
relationship: positively_regulates GO:0036395 ! pancreatic amylase secretion

[Term]
id: GO:1902279
name: positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway
namespace: biological_process
def: "A cholecystokinin signaling pathway that results in positive regulation of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687]
synonym: "activation of pancreatic amylase secretion by cholecystokinin signaling pathway" NARROW [GOC:TermGenie]
synonym: "CCK-induced amylase release in pancreatic cell" EXACT [PMID:19028687]
synonym: "CCK-mediated pancreatic amylase secretion" EXACT [PMID:19028687]
synonym: "CCK-stimulated pancreatic amylase release" EXACT [PMID:19028687]
synonym: "cholecystokinin-mediated pancreatic amylase secretion" EXACT [PMID:19028687]
synonym: "up regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0038188 ! cholecystokinin signaling pathway
is_a: GO:1902278 ! positive regulation of pancreatic amylase secretion

[Term]
id: GO:1902280
name: regulation of RNA helicase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ATP-dependent RNA helicase activity" EXACT []
is_a: GO:0051095 ! regulation of helicase activity

[Term]
id: GO:1902281
name: obsolete negative regulation of RNA helicase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP-dependent RNA helicase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP-dependent RNA helicase activity" EXACT []
is_obsolete: true

[Term]
id: GO:1902282
name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:8528244]
synonym: "voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

[Term]
id: GO:1902283
name: negative regulation of primary amine oxidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary amine oxidase activity." [GOC:TermGenie, PMID:23349812]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "down regulation of primary amine oxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of primary amine oxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "downregulation of primary amine oxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of primary amine oxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of primary-amine:oxygen oxidoreductase (deaminating) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity

[Term]
id: GO:1902284
name: neuron projection extension involved in neuron projection guidance
namespace: biological_process
def: "Any neuron projection extension that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "neurite extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuron process guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuron projection guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuron protrusion guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuronal cell projection guidance" NARROW [GOC:TermGenie]
synonym: "neuron process extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuron process extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuron process extension involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron process extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuron process extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron projection extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuron projection extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuron projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuron projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
is_a: GO:1990138 ! neuron projection extension
relationship: part_of GO:0097485 ! neuron projection guidance

[Term]
id: GO:1902285
name: semaphorin-plexin signaling pathway involved in neuron projection guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "semaphorin-plexin signaling pathway involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
relationship: part_of GO:0097485 ! neuron projection guidance

[Term]
id: GO:1902286
name: semaphorin-plexin signaling pathway involved in dendrite guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in dendrite guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "semaphorin-plexin signaling pathway involved in dendritic guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in dendrite guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in dendritic guidance" EXACT [GOC:TermGenie]
is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance
relationship: part_of GO:0070983 ! dendrite guidance

[Term]
id: GO:1902287
name: semaphorin-plexin signaling pathway involved in axon guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "semaphorin-plexin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:1902288
name: regulation of defense response to oomycetes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0002229 ! defense response to oomycetes

[Term]
id: GO:1902289
name: negative regulation of defense response to oomycetes
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633]
synonym: "down regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to oomycetes" NARROW [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:1902288 ! regulation of defense response to oomycetes
relationship: negatively_regulates GO:0002229 ! defense response to oomycetes

[Term]
id: GO:1902290
name: positive regulation of defense response to oomycetes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633]
synonym: "activation of defense response to oomycetes" NARROW [GOC:TermGenie]
synonym: "up regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to oomycetes" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:1902288 ! regulation of defense response to oomycetes
relationship: positively_regulates GO:0002229 ! defense response to oomycetes

[Term]
id: GO:1902291
name: cell cycle DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA ligation involved in cell cycle DNA replication" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051104 ! DNA-dependent DNA replication DNA ligation
relationship: part_of GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:1902292
name: cell cycle DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA endoreduplication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA re-replication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA replication initiation involved in cell cycle DNA replication" EXACT []
synonym: "DNA-dependent DNA replication initiation involved in cell cycle DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0006270 ! DNA replication initiation
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:1902294
name: cell cycle DNA replication termination
namespace: biological_process
def: "Any DNA replication termination that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication termination involved in cell cycle DNA replication" EXACT []
is_a: GO:0006274 ! DNA replication termination
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:1902295
name: obsolete synthesis of RNA primer involved in cell cycle DNA replication
namespace: biological_process
def: "OBSOLETE. Any DNA replication, synthesis of RNA primer that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that these are precomposed terms that should be captured as GO-CAM models.
synonym: "DNA replication, synthesis of RNA primer involved in cell cycle DNA replication" EXACT []
synonym: "replication priming involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902296
name: DNA strand elongation involved in cell cycle DNA replication
namespace: biological_process
def: "Any DNA strand elongation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication elongation involved in cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA strand elongation during DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
is_a: GO:0006271 ! DNA strand elongation involved in DNA replication
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:1902297
name: cell cycle DNA replication DNA unwinding
namespace: biological_process
def: "Any DNA unwinding that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA unwinding during replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
synonym: "DNA unwinding factor involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
synonym: "DNA unwinding involved in cell cycle DNA replication" EXACT []
is_a: GO:0006268 ! DNA unwinding involved in DNA replication
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:1902298
name: cell cycle DNA replication maintenance of fidelity
namespace: biological_process
def: "Any maintenance of fidelity that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "maintenance of fidelity during DNA-dependent DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
synonym: "maintenance of fidelity involved in cell cycle DNA replication" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0045005 ! DNA-templated DNA replication maintenance of fidelity
relationship: part_of GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:1902299
name: pre-replicative complex assembly involved in cell cycle DNA replication
namespace: biological_process
def: "Any pre-replicative complex assembly that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "pre-RC assembly involved in cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "pre-replication complex assembly involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0036388 ! pre-replicative complex assembly
relationship: part_of GO:0044786 ! cell cycle DNA replication

[Term]
id: GO:1902300
name: galactarate transmembrane transport
namespace: biological_process
alt_id: GO:0042871
def: "The process in which galactaric acid anion (galactarate) is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "D-galactarate transport" RELATED []
synonym: "galactarate transport" RELATED []
synonym: "galactaric acid anion transport" EXACT []
is_a: GO:0042869 ! aldarate transmembrane transport

[Term]
id: GO:1902301
name: galactarate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0042877
def: "Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "D-galactarate transmembrane transporter activity" RELATED []
synonym: "galactaric acid anion transmembrane transporter activity" EXACT []
is_a: GO:0042876 ! aldarate transmembrane transporter activity

[Term]
id: GO:1902305
name: regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: regulates GO:0035725 ! sodium ion transmembrane transport

[Term]
id: GO:1902306
name: negative regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010766 ! negative regulation of sodium ion transport
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
relationship: negatively_regulates GO:0035725 ! sodium ion transmembrane transport

[Term]
id: GO:1902307
name: positive regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010765 ! positive regulation of sodium ion transport
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
relationship: positively_regulates GO:0035725 ! sodium ion transmembrane transport

[Term]
id: GO:1902308
name: obsolete regulation of peptidyl-serine dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
is_obsolete: true

[Term]
id: GO:1902309
name: obsolete negative regulation of peptidyl-serine dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "down regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902310
name: obsolete positive regulation of peptidyl-serine dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "activation of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie]
synonym: "up regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902311
name: regulation of copper ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137]
synonym: "regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010959 ! regulation of metal ion transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: regulates GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:1902312
name: negative regulation of copper ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137]
synonym: "down regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of copper cation transmembrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of copper ion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of copper ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "negative regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:1902311 ! regulation of copper ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
relationship: negatively_regulates GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:1902313
name: positive regulation of copper ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137]
synonym: "activation of copper cation transmembrane transport" NARROW [GOC:TermGenie]
synonym: "activation of copper ion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of copper ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:1902311 ! regulation of copper ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
relationship: positively_regulates GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:1902314
name: hydroquinone binding
namespace: molecular_function
def: "Binding to hydroquinone." [GOC:bhm, GOC:TermGenie, PMID:15667223]
synonym: "quinol binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:1902315
name: nuclear cell cycle DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA endoreduplication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA re-replication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA replication initiation involved in nuclear cell cycle DNA replication" EXACT []
is_a: GO:1902292 ! cell cycle DNA replication initiation
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:1902317
name: nuclear DNA replication termination
namespace: biological_process
def: "Any DNA replication termination that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication termination involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA replication termination involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA replication termination involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA replication termination involved in nuclear cell cycle DNA replication" EXACT []
is_a: GO:1902294 ! cell cycle DNA replication termination
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:1902318
name: obsolete synthesis of RNA primer involved in nuclear cell cycle DNA replication
namespace: biological_process
def: "OBSOLETE. Any synthesis of RNA primer that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that these are precomposed terms that should be captured as GO-CAM models.
synonym: "DNA replication, synthesis of RNA primer involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "replication priming involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "replication priming involved in DNA replication involved in S phase" RELATED [GOC:TermGenie]
synonym: "replication priming involved in DNA replication involved in S-phase" RELATED [GOC:TermGenie]
synonym: "replication priming involved in nuclear cell cycle DNA replication" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902319
name: DNA strand elongation involved in nuclear cell cycle DNA replication
namespace: biological_process
def: "Any DNA strand elongation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA strand elongation involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA strand elongation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA strand elongation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
is_a: GO:1902296 ! DNA strand elongation involved in cell cycle DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:1902320
name: nuclear DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA duplex unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA duplex unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA duplex unwinding involved in nuclear cell cycle DNA replication" EXACT []
synonym: "DNA unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA unwinding involved in nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "duplex DNA melting involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "duplex DNA melting involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "duplex DNA melting involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:1902321
name: methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methyl-branched fatty acid." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0097089 ! methyl-branched fatty acid metabolic process

[Term]
id: GO:1902322
name: regulation of methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
relationship: regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process

[Term]
id: GO:1902323
name: negative regulation of methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "down regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid formation" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process
relationship: negatively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process

[Term]
id: GO:1902324
name: positive regulation of methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "activation of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid formation" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process
relationship: positively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process

[Term]
id: GO:1902325
name: negative regulation of chlorophyll biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952]
synonym: "down regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chlorophyll anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll formation" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
relationship: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process

[Term]
id: GO:1902326
name: positive regulation of chlorophyll biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952]
synonym: "activation of chlorophyll anabolism" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll formation" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
relationship: positively_regulates GO:0015995 ! chlorophyll biosynthetic process

[Term]
id: GO:1902327
name: bacterial-type DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA ligation involved in bacterial-type DNA replication" EXACT []
is_a: GO:1902291 ! cell cycle DNA replication DNA ligation
relationship: part_of GO:0044787 ! bacterial-type DNA replication

[Term]
id: GO:1902328
name: bacterial-type DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA endoreduplication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA re-replication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA replication initiation involved in bacterial-type DNA replication" EXACT []
synonym: "DNA-dependent DNA replication initiation involved in bacterial-type DNA replication" EXACT [GOC:TermGenie]
is_a: GO:1902292 ! cell cycle DNA replication initiation
relationship: part_of GO:0044787 ! bacterial-type DNA replication

[Term]
id: GO:1902329
name: bacterial-type DNA replication termination
namespace: biological_process
def: "Any DNA replication termination that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication termination involved in bacterial-type DNA replication" EXACT []
is_a: GO:1902294 ! cell cycle DNA replication termination
relationship: part_of GO:0044787 ! bacterial-type DNA replication

[Term]
id: GO:1902330
name: obsolete synthesis of RNA primer involved in bacterial-type DNA replication
namespace: biological_process
def: "OBSOLETE. Any synthesis of RNA primer that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that these are precomposed terms that should be captured as GO-CAM models.
synonym: "replication priming involved in bacterial-type DNA replication" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902331
name: obsolete DNA strand elongation involved in bacterial-type DNA replication
namespace: biological_process
def: "OBSOLETE. Any DNA strand elongation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: This term was obsoleted because it does not represent a distinct function from its parent, DNA strand elongation involved in DNA replication.
is_obsolete: true

[Term]
id: GO:1902332
name: bacterial-type DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in bacterial-type DNA replication" EXACT []
synonym: "DNA unwinding involved in bacterial-type DNA replication" EXACT [GOC:TermGenie]
synonym: "duplex DNA melting involved in bacterial-type DNA replication" EXACT [GOC:TermGenie]
is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding
relationship: part_of GO:0044787 ! bacterial-type DNA replication

[Term]
id: GO:1902333
name: nuclear DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA ligation involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA ligation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA ligation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA ligation involved in nuclear cell cycle DNA replication" EXACT []
is_a: GO:1902291 ! cell cycle DNA replication DNA ligation
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:1902334
name: fructose export from vacuole to cytoplasm
namespace: biological_process
def: "The directed movement of fructose from vacuole to cytoplasm." [GOC:TermGenie, PMID:23583552]
synonym: "fructose transport from vacuole to cytoplasm" EXACT []
is_a: GO:0015755 ! fructose transmembrane transport
is_a: GO:0034486 ! vacuolar transmembrane transport

[Term]
id: GO:1902335
name: obsolete positive chemotaxis involved in neuron migration
namespace: biological_process
def: "OBSOLETE. Any positive chemotaxis that is involved in neuron migration." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemoattraction involved in neuron chemotaxis" EXACT [GOC:TermGenie]
synonym: "chemoattraction involved in neuron guidance" RELATED [GOC:TermGenie]
synonym: "chemoattraction involved in neuron migration" EXACT [GOC:TermGenie]
synonym: "chemoattraction involved in neuronal migration" EXACT [GOC:TermGenie]
synonym: "positive chemotaxis involved in neuron chemotaxis" EXACT [GOC:TermGenie]
synonym: "positive chemotaxis involved in neuron guidance" RELATED [GOC:TermGenie]
synonym: "positive chemotaxis involved in neuron migration" EXACT []
synonym: "positive chemotaxis involved in neuronal migration" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902336
name: positive regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
synonym: "activation of retinal ganglion cell axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of retinal ganglion cell axon pathfinding" NARROW [GOC:TermGenie]
synonym: "positive regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance
is_a: GO:1902669 ! positive regulation of axon guidance
relationship: positively_regulates GO:0031290 ! retinal ganglion cell axon guidance

[Term]
id: GO:1902337
name: regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1904748 ! regulation of apoptotic process involved in development
relationship: regulates GO:0060561 ! apoptotic process involved in morphogenesis

[Term]
id: GO:1902338
name: negative regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
relationship: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis

[Term]
id: GO:1902339
name: positive regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
relationship: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis

[Term]
id: GO:1902340
name: negative regulation of chromosome condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725]
synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie]
synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0060623 ! regulation of chromosome condensation
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0030261 ! chromosome condensation

[Term]
id: GO:1902341
name: xylitol transmembrane transport
namespace: biological_process
def: "The directed movement of a xylitol across a membrane. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose." [GOC:TermGenie, PMID:23475614]
synonym: "xylitol transport" BROAD []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:1902342
name: obsolete xylitol export
namespace: biological_process
def: "OBSOLETE. The directed movement of xylitol out of a cell or organelle." [GOC:TermGenie, PMID:23475614]
comment: This term was obsoleted because there is is no specific process for xylitol export.
is_obsolete: true

[Term]
id: GO:1902343
name: regulation of maltose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015768 ! maltose transport

[Term]
id: GO:1902344
name: negative regulation of maltose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568]
synonym: "down regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1902343 ! regulation of maltose transport
relationship: negatively_regulates GO:0015768 ! maltose transport

[Term]
id: GO:1902345
name: positive regulation of maltose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568]
synonym: "activation of maltose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1902343 ! regulation of maltose transport
relationship: positively_regulates GO:0015768 ! maltose transport

[Term]
id: GO:1902346
name: meiotic strand displacement involved in double-strand break repair via SDSA
namespace: biological_process
def: "Any meiotic strand displacement that is involved in double-strand break repair via synthesis-dependent strand annealing (SDSA)." [GOC:al, GOC:TermGenie, PMID:22723423]
synonym: "meiotic D-loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic D-loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic D-loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic D-loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic strand displacement involved in double-strand break repair via synthesis-dependent strand annealing" EXACT []
synonym: "meiotic strand displacement involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic strand displacement involved in SDSA" BROAD []
is_a: GO:0000714 ! meiotic strand displacement
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:1902347
name: response to strigolactone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171]
synonym: "response to strigolactone analog GR24" RELATED [PMID:23893171]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1902348
name: cellular response to strigolactone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171]
synonym: "cellular response to strigolactone analog GR24" RELATED [PMID:23893171]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902347 ! response to strigolactone

[Term]
id: GO:1902349
name: response to chloroquine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1902350
name: cellular response to chloroquine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1902349 ! response to chloroquine

[Term]
id: GO:1902351
name: response to imidacloprid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1902352
name: obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:rn, GOC:TermGenie, PMID:23223039]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1902353
name: obsolete positive regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter by pheromones that results in positive regulation of induction of conjugation with cellular fusion." [GOC:rn, GOC:TermGenie, PMID:23872066]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "up regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie]
synonym: "up-regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie]
synonym: "upregulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902354
name: blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment
namespace: biological_process
def: "Any blood vessel endothelial cell delamination that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350]
is_a: GO:0097497 ! blood vessel endothelial cell delamination
relationship: part_of GO:0097496 ! blood vessel lumen ensheathment

[Term]
id: GO:1902355
name: endothelial tube lumen extension involved in blood vessel lumen ensheathment
namespace: biological_process
def: "Any endothelial tube lumen extension that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350]
is_a: GO:0097498 ! endothelial tube lumen extension
relationship: part_of GO:0097496 ! blood vessel lumen ensheathment

[Term]
id: GO:1902356
name: oxaloacetate(2-) transmembrane transport
namespace: biological_process
def: "The directed movement of oxaloacetate(2-) across a membrane." [GOC:dph, GOC:TermGenie, PMID:18682385]
is_a: GO:0015729 ! oxaloacetate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1902357
name: 2-isopropylmalate(2-) transmembrane transport
namespace: biological_process
def: "The process in which 2-isopropylmalate(2-) is transported across a membrane." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:18682385]
is_a: GO:0034659 ! isopropylmalate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1902358
name: sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073]
synonym: "sulphate transport" EXACT []
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:1902359
name: Notch signaling pathway involved in somitogenesis
namespace: biological_process
def: "Any Notch signaling pathway that is involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391]
synonym: "N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:1902360
name: obsolete conversion of ds siRNA to ss siRNA involved in gene silencing by small RNA
namespace: biological_process
def: "OBSOLETE. Any conversion of ds siRNA to ss siRNA that is involved in gene silencing by small RNA." [GOC:TermGenie, GOC:vw, PMID:19239886]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in chromatin silencing by small RNA" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA interference-like chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA-mediated chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA-mediated transcriptional silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNAi-directed chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNAi-like chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in small RNA-mediated heterochromatic silencing" RELATED [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in chromatin silencing by small RNA" EXACT []
synonym: "conversion of ds siRNA to ss siRNA involved in RNA interference-like chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated transcriptional silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-directed chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-like chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in small RNA-mediated heterochromatic silencing" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0004521
consider: GO:0031047

[Term]
id: GO:1902362
name: melanocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a melanocyte, the main structural component of the epidermis." [GOC:ic, GOC:TermGenie, PMID:20530876]
synonym: "melanocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "melanophore apoptosis" NARROW [GOC:TermGenie]
synonym: "melanophore apoptotic process" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:1902363
name: regulation of protein localization to spindle pole body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906]
synonym: "regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0071988 ! protein localization to spindle pole body

[Term]
id: GO:1902364
name: negative regulation of protein localization to spindle pole body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906]
synonym: "down regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to spindle pole body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to spindle pole body" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:1902363 ! regulation of protein localization to spindle pole body
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:0071988 ! protein localization to spindle pole body

[Term]
id: GO:1902365
name: positive regulation of protein localization to spindle pole body
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906]
synonym: "activation of protein localisation to spindle pole body" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to spindle pole body" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:1902363 ! regulation of protein localization to spindle pole body
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:0071988 ! protein localization to spindle pole body

[Term]
id: GO:1902366
name: regulation of Notch signaling pathway involved in somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391]
synonym: "regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:0008593 ! regulation of Notch signaling pathway
relationship: regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis

[Term]
id: GO:1902367
name: negative regulation of Notch signaling pathway involved in somitogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391]
synonym: "down regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of N signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of N signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of N signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of N signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:0045746 ! negative regulation of Notch signaling pathway
is_a: GO:1902366 ! regulation of Notch signaling pathway involved in somitogenesis
relationship: negatively_regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis

[Term]
id: GO:1902369
name: negative regulation of RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]
synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
relationship: negatively_regulates GO:0006401 ! RNA catabolic process

[Term]
id: GO:1902370
name: regulation of tRNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie]
synonym: "regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
relationship: regulates GO:0016078 ! tRNA decay

[Term]
id: GO:1902371
name: negative regulation of tRNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22919049]
synonym: "down regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:1902369 ! negative regulation of RNA catabolic process
is_a: GO:1902370 ! regulation of tRNA catabolic process
is_a: GO:1903327 ! negative regulation of tRNA metabolic process
relationship: negatively_regulates GO:0016078 ! tRNA decay

[Term]
id: GO:1902372
name: positive regulation of tRNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie]
synonym: "activation of tRNA breakdown" NARROW [GOC:TermGenie]
synonym: "activation of tRNA catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tRNA catabolism" NARROW [GOC:TermGenie]
synonym: "activation of tRNA degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1902370 ! regulation of tRNA catabolic process
is_a: GO:1903328 ! positive regulation of tRNA metabolic process
relationship: positively_regulates GO:0016078 ! tRNA decay

[Term]
id: GO:1902373
name: negative regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865]
synonym: "down regulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "down regulation of mRNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "down-regulation of mRNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "downregulation of mRNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA decay" RELATED [GOC:TermGenie]
synonym: "inhibition of mRNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "negative regulation of mRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0061013 ! regulation of mRNA catabolic process
is_a: GO:1902369 ! negative regulation of RNA catabolic process
is_a: GO:1903312 ! negative regulation of mRNA metabolic process
relationship: negatively_regulates GO:0006402 ! mRNA catabolic process

[Term]
id: GO:1902374
name: regulation of rRNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:20160119]
synonym: "regulation of rRNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of rRNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of rRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0016075 ! rRNA catabolic process

[Term]
id: GO:1902375
name: obsolete nuclear tRNA 3'-trailer cleavage, endonucleolytic
namespace: biological_process
def: "OBSOLETE. Any tRNA 3'-trailer cleavage, endonucleolytic that takes place in nucleus." [GOC:TermGenie, PMID:23928301]
comment: The reason for obsoletion is that these term represent molecular functions.
synonym: "endonucleolytic tRNA 3'-end cleavage in cell nucleus" EXACT [GOC:TermGenie]
synonym: "endonucleolytic tRNA 3'-end cleavage in nucleus" EXACT [GOC:TermGenie]
synonym: "endonucleolytic tRNA 3'-trailer cleavage in cell nucleus" RELATED [GOC:TermGenie]
synonym: "endonucleolytic tRNA 3'-trailer cleavage in nucleus" RELATED [GOC:TermGenie]
synonym: "tRNA 3'-end cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie]
synonym: "tRNA 3'-end cleavage, endonucleolytic in nucleus" EXACT [GOC:TermGenie]
synonym: "tRNA 3'-trailer cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0042780

[Term]
id: GO:1902376
name: obsolete protein denaturation involved in proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any protein denaturation that is involved in proteasomal ubiquitin-dependent protein catabolic process." [GOC:TermGenie, PMID:21091378]
comment: This term was made obsolete because it was poorly defined and the intended usage was unclear.
synonym: "protein denaturation involved in proteasomal pathway" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal processing" RELATED [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasome pathway" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902378
name: VEGF-activated neuropilin signaling pathway involved in axon guidance
namespace: biological_process
def: "Any VEGF-activated neuropilin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
synonym: "VEGF-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "VEGF-activated neuropilin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "VEGF-activated neuropilin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon guidance" NARROW [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon pathfinding" NARROW [GOC:TermGenie]
is_a: GO:0038190 ! VEGF-activated neuropilin signaling pathway
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:1902379
name: chemoattractant activity involved in axon guidance
namespace: molecular_function
def: "Any chemoattractant activity that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
synonym: "chemoattractant activity involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "chemoattractant activity involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "chemoattractant activity involved in axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0042056 ! chemoattractant activity

[Term]
id: GO:1902380
name: positive regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endoribonuclease activity." [GOC:bf, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "activation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "activation of endoribonuclease activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "up regulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "up regulation of endoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of endoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "upregulation of endoribonuclease activity" EXACT [GOC:TermGenie]
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0060699 ! regulation of endoribonuclease activity

[Term]
id: GO:1902381
name: 11-oxo-beta-amyrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 11-oxo-beta-amyrin." [GOC:TermGenie, PMID:22128119]
synonym: "11-oxo-beta-amyrin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1902382
name: 11-oxo-beta-amyrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 11-oxo-beta-amyrin." [GOC:TermGenie, PMID:22128119]
synonym: "11-oxo-beta-amyrin breakdown" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin catabolism" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process

[Term]
id: GO:1902383
name: 11-oxo-beta-amyrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 11-oxo-beta-amyrin." [GOC:TermGenie, PMID:22128119]
synonym: "11-oxo-beta-amyrin anabolism" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin biosynthesis" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin formation" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process

[Term]
id: GO:1902384
name: glycyrrhetinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycyrrhetinate." [GOC:TermGenie, PMID:22128119]
synonym: "glycyrrhetinate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:1902385
name: glycyrrhetinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycyrrhetinate." [GOC:TermGenie, PMID:22128119]
synonym: "glycyrrhetinate breakdown" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate catabolism" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1902384 ! glycyrrhetinate metabolic process

[Term]
id: GO:1902386
name: glycyrrhetinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycyrrhetinate." [GOC:TermGenie, PMID:22128119]
synonym: "glycyrrhetinate anabolism" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate formation" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1902384 ! glycyrrhetinate metabolic process

[Term]
id: GO:1902387
name: ceramide 1-phosphate binding
namespace: molecular_function
def: "Binding to ceramide 1-phosphate." [GOC:TermGenie, PMID:23863933]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0043168 ! anion binding
is_a: GO:0097001 ! ceramide binding

[Term]
id: GO:1902388
name: ceramide 1-phosphate transfer activity
namespace: molecular_function
def: "Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:TermGenie, PMID:23863933]
synonym: "ceramide 1-phosphate carrier activity" EXACT []
synonym: "ceramide 1-phosphate transporter activity" BROAD []
synonym: "intermembrane ceramide 1-phosphate transfer activity" NARROW []
xref: Reactome:R-HSA-5339535 "CPTP transports C1P from plasma membrane to Golgi membrane"
is_a: GO:0120014 ! phospholipid transfer activity
is_a: GO:0120017 ! ceramide transfer activity

[Term]
id: GO:1902389
name: ceramide 1-phosphate transport
namespace: biological_process
def: "The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:23863933]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0035627 ! ceramide transport

[Term]
id: GO:1902390
name: obsolete regulation of N-terminal peptidyl-serine acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1902391
name: obsolete positive regulation of N-terminal peptidyl-serine acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of N-terminal peptidyl-serine acetylation" NARROW [GOC:TermGenie]
synonym: "up regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902392
name: regulation of exodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:1905777 ! regulation of exonuclease activity

[Term]
id: GO:1902393
name: obsolete negative regulation of exodeoxyribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "inhibition of exodeoxyribonuclease activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902394
name: obsolete positive regulation of exodeoxyribonuclease activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie, PMID:1234]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of exodeoxyribonuclease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902395
name: obsolete regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of 1-deoxy-D-xylulose-5-phosphate synthase activity." [GOC:TermGenie, PMID:23612965]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 1-deoxyxylulose-5-phosphate synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DOXP synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DXP-synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902396
name: protein localization to bicellular tight junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111]
synonym: "protein localisation in tight junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to tight junction" EXACT [GOC:TermGenie]
synonym: "protein localization in tight junction" EXACT [GOC:TermGenie]
is_a: GO:0150105 ! protein localization to cell-cell junction

[Term]
id: GO:1902397
name: obsolete detection of stimulus involved in meiotic spindle checkpoint
namespace: biological_process
def: "OBSOLETE. Any detection of stimulus that is involved in meiotic spindle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "perception of stimulus involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902399
name: obsolete detection of stimulus involved in G1 DNA damage checkpoint
namespace: biological_process
def: "OBSOLETE. Any detection of stimulus that is involved in G1 DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "perception of stimulus involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "perception of stimulus involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus detection involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus sensing involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902401
name: obsolete detection of stimulus involved in mitotic DNA damage checkpoint
namespace: biological_process
def: "OBSOLETE. Any detection of stimulus that is involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "perception of stimulus involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902404
name: mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any actomyosin contractile ring contraction that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "mitotic actomyosin contractile ring constriction" EXACT [GOC:vw]
is_a: GO:0000916 ! actomyosin contractile ring contraction
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1902405
name: obsolete mitotic actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any actomyosin contractile ring localization that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
is_obsolete: true
replaced_by: GO:1902408

[Term]
id: GO:1902406
name: mitotic actomyosin contractile ring maturation
namespace: biological_process
def: "The cellular process in which the mitotic contractile ring cytokinetic ring attains its fully functional state." [PMID:25451933]
synonym: "mitotic cytokinesis contractile ring maintenance" RELATED []
is_a: GO:0031566 ! actomyosin contractile ring maturation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:1902407
name: assembly of actomyosin apparatus involved in mitotic cytokinesis
namespace: biological_process
def: "Any assembly of mitotic cytokinetic actomyosin apparatus." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "actomyosin apparatus assembly involved in cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, formation of actomyosin apparatus involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "formation of actomyosin apparatus involved in cytokinesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1902408
name: mitotic cytokinesis, division site positioning
namespace: biological_process
def: "The process in which a contractile ring is positioned in a specific location during the mitotic cell cycle. This process is critical for both for both symmetric and asymmetric cell divisions." [PMID:26553932, PMID:28162898]
synonym: "mitotic cytokinesis, site selection" EXACT []
is_a: GO:0007105 ! cytokinesis, division site positioning
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1902410
name: mitotic cytokinetic process
namespace: biological_process
def: "Any cytokinetic process that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:1902412
name: regulation of mitotic cytokinesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
is_a: GO:0032465 ! regulation of cytokinesis
relationship: regulates GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:1902413
name: negative regulation of mitotic cytokinesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:1902412 ! regulation of mitotic cytokinesis
relationship: negatively_regulates GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:1902414
name: protein localization to cell junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111]
synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie]
synonym: "protein localization in cell junction" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1902415
name: regulation of mRNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846]
subset: gocheck_do_not_annotate
is_a: GO:1905214 ! regulation of RNA binding

[Term]
id: GO:1902416
name: positive regulation of mRNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846]
subset: gocheck_do_not_annotate
synonym: "activation of mRNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
is_a: GO:1905216 ! positive regulation of RNA binding

[Term]
id: GO:1902417
name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other." [GOC:TermGenie, PMID:24028845]
synonym: "ABA-GE transmembrane transporter activity" EXACT []
synonym: "abscisic acid glucosyl ester transmembrane transporter activity" EXACT []
is_a: GO:0042947 ! glucoside transmembrane transporter activity

[Term]
id: GO:1902418
name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transport
namespace: biological_process
def: "The process in which (+)-abscisic acid D-glucopyranosyl este is transported across a membrane." [GOC:TermGenie, PMID:24028845]
synonym: "ABA-GE transmembrane transport" EXACT []
synonym: "abscisic acid glucosyl ester transmembrane transport" EXACT []
is_a: GO:0042946 ! glucoside transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1902421
name: hydrogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761]
synonym: "dihydrogen metabolism" EXACT [GOC:TermGenie]
synonym: "H2 metabolism" EXACT []
synonym: "molecular hydrogen metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1902422
name: hydrogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761]
synonym: "dihydrogen synthesis" EXACT [GOC:jl]
synonym: "H2 biosynthesis" EXACT []
synonym: "hydrogen anabolism" EXACT [GOC:TermGenie]
synonym: "hydrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "hydrogen formation" EXACT [GOC:TermGenie]
synonym: "hydrogen generation" EXACT [GOC:jl]
synonym: "hydrogen production" EXACT []
synonym: "hydrogen synthesis" EXACT [GOC:TermGenie]
synonym: "molecular hydrogen biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1902421 ! hydrogen metabolic process

[Term]
id: GO:1902423
name: regulation of attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, GOC:vw, PMID:22065639]
synonym: "regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic attachment of spindle microtubules to kinetochore" EXACT []
synonym: "regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
is_a: GO:0090235 ! regulation of metaphase plate congression
relationship: regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:1902424
name: negative regulation of attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, GOC:vw, PMID:22065639]
synonym: "down regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "down regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "negative regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "negative regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic attachment of spindle microtubules to kinetochore" EXACT []
synonym: "negative regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
is_a: GO:0051986 ! negative regulation of attachment of spindle microtubules to kinetochore
is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore
relationship: negatively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:1902425
name: positive regulation of attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, PMID:22065639]
synonym: "activation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie]
synonym: "activation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "positive regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore
is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore
relationship: positively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:1902426
name: deactivation of mitotic spindle assembly checkpoint
namespace: biological_process
def: "A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:19075002, PMID:19592249]
comment: A mitotic spindle assembly checkpoint is either activated or switched off; no other means of reducing the frequency, rate or extent of this process are currently known.
synonym: "down regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "down regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie]
synonym: "down regulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie]
synonym: "down-regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "down-regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie]
synonym: "down-regulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie]
synonym: "downregulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "downregulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie]
synonym: "downregulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie]
synonym: "inhibition of Mad2-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "inhibition of mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:TermGenie]
synonym: "inhibition of mitotic spindle assembly checkpoint" RELATED [GOC:TermGenie]
synonym: "mitotic spindle assembly checkpoint silencing" EXACT []
synonym: "mitotic spindle assembly deactivation" EXACT []
synonym: "negative regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie]
synonym: "negative regulation of mitotic spindle assembly checkpoint" BROAD []
is_a: GO:0140499 ! negative regulation of mitotic spindle assembly checkpoint signaling

[Term]
id: GO:1902427
name: regulation of water channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752]
subset: gocheck_obsoletion_candidate
synonym: "regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "regulation of aquaporin permeability" NARROW [PMID:22095752]
is_a: GO:0022898 ! regulation of transmembrane transporter activity

[Term]
id: GO:1902428
name: obsolete negative regulation of water channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of water channel activity." [GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "down regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "down-regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "downregulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of aquaporin" NARROW [GOC:TermGenie]
synonym: "inhibition of water channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of aquaporin" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902429
name: positive regulation of water channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752]
subset: gocheck_obsoletion_candidate
synonym: "activation of aquaporin" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity" NARROW [GOC:TermGenie]
synonym: "aquaporin activation" NARROW [PMID:22095752]
synonym: "positive regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "up regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "up regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "up-regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "upregulation of water channel activity" EXACT [GOC:TermGenie]
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1902427 ! regulation of water channel activity

[Term]
id: GO:1902430
name: negative regulation of amyloid-beta formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation." [GOC:hjd, GOC:TermGenie, PMID:22992957]
synonym: "down regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-amyloid formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-amyloid formation" EXACT []
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:1902003 ! regulation of amyloid-beta formation
is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process
relationship: negatively_regulates GO:0034205 ! amyloid-beta formation

[Term]
id: GO:1902432
name: protein localization to division septum
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a division septum." [GOC:TermGenie, PMID:9367977]
synonym: "protein localisation in division septum" EXACT [GOC:TermGenie]
synonym: "protein localisation to division septum" EXACT [GOC:TermGenie]
synonym: "protein localization in division septum" EXACT [GOC:TermGenie]
is_a: GO:0072741 ! protein localization to cell division site

[Term]
id: GO:1902433
name: obsolete positive regulation of water channel activity involved in maintenance of lens transparency
namespace: biological_process
def: "OBSOLETE. Any positive regulation of water channel activity that is involved in maintenance of lens transparency." [GOC:nhn, GOC:TermGenie, PMID:22095752]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "aquaporin activation involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "aquaporin activation involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "aquaporin activation involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "positive regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
synonym: "up regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "up regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "up regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "up regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie]
synonym: "up regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "up regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
synonym: "up-regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "up-regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "up-regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "up-regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie]
synonym: "up-regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "up-regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
synonym: "upregulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "upregulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "upregulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "upregulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie]
synonym: "upregulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "upregulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902434
name: sulfate import across plasma membrane
namespace: biological_process
def: "The directed movement of sulfate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:TermGenie, PMID:14723223]
synonym: "sulfate import into cell" EXACT []
synonym: "sulphate import into cell" EXACT []
is_a: GO:0098658 ! inorganic anion import across plasma membrane
is_a: GO:1902358 ! sulfate transmembrane transport

[Term]
id: GO:1902435
name: regulation of male mating behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208]
is_a: GO:0050795 ! regulation of behavior
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0060179 ! male mating behavior

[Term]
id: GO:1902436
name: negative regulation of male mating behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208]
synonym: "down regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "down-regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "downregulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "inhibition of male mating behavior" NARROW [GOC:TermGenie]
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1902435 ! regulation of male mating behavior
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0060179 ! male mating behavior

[Term]
id: GO:1902437
name: positive regulation of male mating behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208]
synonym: "activation of male mating behavior" NARROW [GOC:TermGenie]
synonym: "up regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "up-regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "upregulation of male mating behavior" EXACT [GOC:TermGenie]
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1902435 ! regulation of male mating behavior
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0060179 ! male mating behavior

[Term]
id: GO:1902438
name: response to vanadate(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1902439
name: cellular response to vanadate(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902438 ! response to vanadate(3-)

[Term]
id: GO:1902440
name: protein localization to mitotic spindle pole body
namespace: biological_process
alt_id: GO:1990975
def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body." [GOC:TermGenie, PMID:22438582]
synonym: "establishment of protein localization to mitotic spindle pole body" NARROW []
synonym: "protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localization in mitotic spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:0071988 ! protein localization to spindle pole body

[Term]
id: GO:1902441
name: protein localization to meiotic spindle pole body
namespace: biological_process
alt_id: GO:1990945
alt_id: GO:1990954
def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body." [PMID:20833892]
synonym: "establishment of protein localization to meiotic spindle pole body" NARROW []
synonym: "protein localisation in meiotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localisation to meiotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localization in meiotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein location to meiotic spindle pole body" EXACT []
is_a: GO:0071988 ! protein localization to spindle pole body
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:1990395 ! meiotic spindle pole body organization

[Term]
id: GO:1902442
name: regulation of ripoptosome assembly involved in necroptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097]
synonym: "regulation of ripoptosome assembly involved in necroptosis" NARROW []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process

[Term]
id: GO:1902443
name: negative regulation of ripoptosome assembly involved in necroptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097]
synonym: "down regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of ripoptosome assembly involved in necroptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of ripoptosome assembly involved in necroptosis" NARROW []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1902442 ! regulation of ripoptosome assembly involved in necroptotic process
relationship: negatively_regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process

[Term]
id: GO:1902444
name: riboflavin binding
namespace: molecular_function
def: "Binding to riboflavin." [GOC:TermGenie, PMID:12083520]
is_a: GO:0043168 ! anion binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:1902445
name: regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
namespace: biological_process
def: "Any regulation of mitochondrial membrane permeability that is involved in programmed necrotic cell death." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:22493254]
synonym: "regulation of transport across mitochondrial membrane involved in programmed necrotic cell death" EXACT [GOC:TermGenie]
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
relationship: part_of GO:0097300 ! programmed necrotic cell death

[Term]
id: GO:1902446
name: regulation of shade avoidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263]
is_a: GO:2000030 ! regulation of response to red or far red light
relationship: regulates GO:0009641 ! shade avoidance

[Term]
id: GO:1902447
name: negative regulation of shade avoidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263]
synonym: "down regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "downregulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "inhibition of shade avoidance" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1902446 ! regulation of shade avoidance
relationship: negatively_regulates GO:0009641 ! shade avoidance

[Term]
id: GO:1902448
name: positive regulation of shade avoidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263]
synonym: "activation of shade avoidance" NARROW [GOC:TermGenie]
synonym: "up regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "upregulation of shade avoidance" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1902446 ! regulation of shade avoidance
relationship: positively_regulates GO:0009641 ! shade avoidance

[Term]
id: GO:1902455
name: negative regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033]
synonym: "down regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down-regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "downregulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "inhibition of stem cell maintenance" NARROW [GOC:TermGenie]
synonym: "negative regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000036 ! regulation of stem cell population maintenance
relationship: negatively_regulates GO:0019827 ! stem cell population maintenance

[Term]
id: GO:1902456
name: regulation of stomatal opening
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366]
is_a: GO:0010119 ! regulation of stomatal movement
relationship: regulates GO:1990069 ! stomatal opening

[Term]
id: GO:1902457
name: negative regulation of stomatal opening
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366]
synonym: "down regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "down-regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "downregulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "inhibition of stomatal opening" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1902456 ! regulation of stomatal opening
relationship: negatively_regulates GO:1990069 ! stomatal opening

[Term]
id: GO:1902458
name: positive regulation of stomatal opening
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366]
synonym: "activation of stomatal opening" NARROW [GOC:TermGenie]
synonym: "up regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "up-regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "upregulation of stomatal opening" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1902456 ! regulation of stomatal opening
relationship: positively_regulates GO:1990069 ! stomatal opening

[Term]
id: GO:1902459
name: positive regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033]
synonym: "activation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "activation of stem cell maintenance" NARROW [GOC:TermGenie]
synonym: "positive regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up-regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "upregulation of stem cell maintenance" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000036 ! regulation of stem cell population maintenance
relationship: positively_regulates GO:0019827 ! stem cell population maintenance

[Term]
id: GO:1902460
name: regulation of mesenchymal stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106]
synonym: "regulation of MSC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0072091 ! regulation of stem cell proliferation
relationship: regulates GO:0097168 ! mesenchymal stem cell proliferation

[Term]
id: GO:1902461
name: negative regulation of mesenchymal stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106]
synonym: "down regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of MSC proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of MSC proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation
is_a: GO:2000647 ! negative regulation of stem cell proliferation
relationship: negatively_regulates GO:0097168 ! mesenchymal stem cell proliferation

[Term]
id: GO:1902462
name: positive regulation of mesenchymal stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106]
synonym: "activation of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of MSC proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of MSC proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation
is_a: GO:2000648 ! positive regulation of stem cell proliferation
relationship: positively_regulates GO:0097168 ! mesenchymal stem cell proliferation

[Term]
id: GO:1902463
name: protein localization to cell leading edge
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326]
synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1902464
name: obsolete regulation of histone H3-K27 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1902465
name: obsolete negative regulation of histone H3-K27 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K27 trimethylation" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902466
name: obsolete positive regulation of histone H3-K27 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3-K27 trimethylation" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902471
name: obsolete regulation of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring localization." [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
is_obsolete: true
replaced_by: GO:1902472

[Term]
id: GO:1902472
name: regulation of mitotic cytokinesis, division site positioning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis, division site positioning." [PMID:9852154]
synonym: "regulation of mitotic cytokinesis, site selection" EXACT []
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
is_a: GO:2000073 ! regulation of cytokinesis, site selection
relationship: regulates GO:1902408 ! mitotic cytokinesis, division site positioning

[Term]
id: GO:1902473
name: regulation of protein localization to synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0035418 ! protein localization to synapse

[Term]
id: GO:1902474
name: positive regulation of protein localization to synapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie]
is_a: GO:1902473 ! regulation of protein localization to synapse
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:0035418 ! protein localization to synapse

[Term]
id: GO:1902475
name: L-alpha-amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1902476
name: chloride transmembrane transport
namespace: biological_process
def: "The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]
is_a: GO:0006821 ! chloride transport
is_a: GO:0098656 ! monoatomic anion transmembrane transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:1902480
name: protein localization to mitotic spindle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle." [GOC:TermGenie, PMID:23885124]
synonym: "protein localisation in mitotic spindle" EXACT [GOC:TermGenie]
synonym: "protein localisation to mitotic spindle" EXACT [GOC:TermGenie]
synonym: "protein localization in mitotic spindle" EXACT [GOC:TermGenie]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton

[Term]
id: GO:1902481
name: gamma-tubulin complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex." [GOC:TermGenie, PMID:23885124]
synonym: "gamma-tubulin complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1902482
name: regulatory T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a regulatory T cell." [GOC:nhn, GOC:TermGenie, PMID:20471291]
synonym: "regulatory T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulatory T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulatory T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070231 ! T cell apoptotic process

[Term]
id: GO:1902483
name: cytotoxic T cell pyroptotic cell death
namespace: biological_process
def: "A pyroptotic cell death process that occurs in a cytotoxic T cell." [PMID:32299851]
synonym: "cytotoxic T cell apoptosis" RELATED [GOC:TermGenie]
synonym: "cytotoxic T cell apoptotic process" RELATED []
synonym: "cytotoxic T cell pyroptotic process" BROAD []
synonym: "cytotoxic T lymphocyte apoptotic process" RELATED [GOC:TermGenie]
synonym: "cytotoxic T-cell apoptosis" RELATED [GOC:TermGenie]
synonym: "cytotoxic T-cell programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0141201 ! pyroptotic cell death

[Term]
id: GO:1902484
name: Sertoli cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a Sertoli cell." [GOC:ic, GOC:TermGenie, PMID:17761895]
synonym: "Sertoli cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1902485
name: L-cysteine binding
namespace: molecular_function
def: "Binding to L-cysteine." [GOC:bhm, GOC:TermGenie, PMID:12941942]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:1902486
name: protein localization to growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a growing cell tip." [GOC:TermGenie, PMID:23041194]
synonym: "protein localisation in growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:1990151 ! protein localization to cell tip

[Term]
id: GO:1902487
name: protein localization to non-growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip." [GOC:TermGenie, PMID:21652630, PMID:23041194]
synonym: "protein localisation in non-growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to non-growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in non-growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:1990151 ! protein localization to cell tip

[Term]
id: GO:1902488
name: cholangiocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800]
synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1902489
name: hepatoblast apoptotic process
namespace: biological_process
def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967]
synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:1902490
name: regulation of sperm capacitation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "regulation of sperm activation" RELATED [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0048240 ! sperm capacitation

[Term]
id: GO:1902491
name: negative regulation of sperm capacitation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "down regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "down regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "down-regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "downregulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "downregulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "inhibition of sperm activation" RELATED [GOC:TermGenie]
synonym: "inhibition of sperm capacitation" NARROW [GOC:TermGenie]
synonym: "negative regulation of sperm activation" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902490 ! regulation of sperm capacitation
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0048240 ! sperm capacitation

[Term]
id: GO:1902492
name: positive regulation of sperm capacitation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "activation of sperm activation" RELATED [GOC:TermGenie]
synonym: "activation of sperm capacitation" NARROW [GOC:TermGenie]
synonym: "positive regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up-regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "upregulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "upregulation of sperm capacitation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902490 ! regulation of sperm capacitation
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0048240 ! sperm capacitation

[Term]
id: GO:1902493
name: acetyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:1902494
name: catalytic complex
namespace: cellular_component
def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]
subset: goslim_metagenomics
synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1902495
name: transmembrane transporter complex
namespace: cellular_component
def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:1902496
name: obsolete protein binding involved in negative regulation of telomere maintenance via telomerase
namespace: molecular_function
def: "OBSOLETE. Any protein binding that is involved in negative regulation of telomere maintenance via telomerase." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:24013504]
comment: The reason for obsoletion is that this should be captured as a GO-CAM model.
synonym: "protein binding involved in down regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie]
synonym: "protein binding involved in down-regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie]
synonym: "protein binding involved in downregulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie]
synonym: "protein binding involved in inhibition of telomere maintenance via telomerase" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902497
name: iron-sulfur cluster transmembrane transport
namespace: biological_process
def: "A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706]
synonym: "iron-sulfur cluster transport" BROAD []
is_a: GO:0034755 ! iron ion transmembrane transport
is_a: GO:1901678 ! iron coordination entity transport

[Term]
id: GO:1902498
name: regulation of protein autoubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405]
synonym: "regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
is_a: GO:0031396 ! regulation of protein ubiquitination
relationship: regulates GO:0051865 ! protein autoubiquitination

[Term]
id: GO:1902499
name: positive regulation of protein autoubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405]
synonym: "activation of protein auto-ubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein auto-ubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein autoubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein autoubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein self-ubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein self-ubiquitinylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:1902498 ! regulation of protein autoubiquitination
relationship: positively_regulates GO:0051865 ! protein autoubiquitination

[Term]
id: GO:1902500
name: vacuolar HOPS complex
namespace: cellular_component
def: "Any HOPS complex that is part of a vacuolar membrane." [GOC:TermGenie, PMID:23645161]
synonym: "vacuolar membrane HOPS complex" EXACT []
is_a: GO:0030897 ! HOPS complex
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:1902501
name: lysosomal HOPS complex
namespace: cellular_component
def: "Any HOPS complex that is part of a lysosomal membrane." [GOC:TermGenie, PMID:23645161]
synonym: "lysosomal membrane HOPS complex" EXACT []
is_a: GO:1902500 ! vacuolar HOPS complex
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:1902502
name: multivesicular body HOPS complex
namespace: cellular_component
def: "Any HOPS complex that is part of a multivesicular body membrane." [GOC:TermGenie, PMID:23645161]
synonym: "multivesicular body membrane HOPS complex" EXACT []
is_a: GO:0030897 ! HOPS complex
relationship: part_of GO:0032585 ! multivesicular body membrane

[Term]
id: GO:1902503
name: adenylyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of adenylyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:11713534]
synonym: "ThiF-ThiS complex" RELATED [GOC:dph]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:1902507
name: thiazole synthase complex
namespace: cellular_component
def: "A protein complex which is capable of thiazole synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933]
is_a: GO:1990228 ! sulfurtransferase complex

[Term]
id: GO:1902508
name: 2-iminoacetate synthase complex
namespace: cellular_component
def: "A protein complex which is capable of 2-iminoacetate synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933]
synonym: "ThiH-ThiG complex" NARROW [GOC:bhm, GOC:dph]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1902509
name: methionine-importing complex
namespace: cellular_component
def: "A protein complex which is capable of methionine-importing activity." [GOC:pr, GOC:TermGenie, PMID:23748165]
synonym: "methionine importer complex" EXACT []
synonym: "methionine importing complex" EXACT []
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1902510
name: regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie]
synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie]
synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1903624 ! regulation of DNA catabolic process
relationship: regulates GO:0006309 ! apoptotic DNA fragmentation

[Term]
id: GO:1902511
name: negative regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903625 ! negative regulation of DNA catabolic process
relationship: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation

[Term]
id: GO:1902512
name: positive regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903626 ! positive regulation of DNA catabolic process
relationship: positively_regulates GO:0006309 ! apoptotic DNA fragmentation

[Term]
id: GO:1902513
name: regulation of organelle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087]
synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:1902514
name: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel." [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048]
synonym: "regulation of generation of L-type calcium current" RELATED []
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
relationship: regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel

[Term]
id: GO:1902515
name: thioredoxin-disulfide reductase complex
namespace: cellular_component
def: "A protein complex which is capable of thioredoxin-disulfide reductase activity." [GOC:bhm, GOC:TermGenie, PMID:10947986]
comment: An example of this is thioredoxin reductase (TrxB) in E. coli [P0A9P4] in PMID:10947986.
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1902516
name: sn-glycerol 3-phosphate binding
namespace: molecular_function
def: "Binding to sn-glycerol 3-phosphate." [GOC:bhm, GOC:TermGenie, PMID:23013274]
comment: An example of this is UgpB in E. coli [P0AG80] - see PMID:23013274.
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:1902517
name: glycerol-3-phosphate-transporting ATPase complex
namespace: cellular_component
def: "A protein complex which is capable of glycerol-3-phosphate-transporting ATPase activity." [GOC:bhm, GOC:TermGenie, PMID:23013274]
comment: An example of this is UgpB in E. coli in PMID:23013274.
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:1902518
name: response to cyclophosphamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1902519
name: response to docetaxel trihydrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to docetaxel" RELATED []
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1902520
name: response to doxorubicin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1903416 ! response to glycoside

[Term]
id: GO:1902521
name: response to etoposide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1904631 ! response to glucoside

[Term]
id: GO:1902522
name: response to 4'-epidoxorubicin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to epirubicin" RELATED []
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1903416 ! response to glycoside

[Term]
id: GO:1902523
name: positive regulation of protein K63-linked ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of protein K63-linked polyubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein K63-linked ubiquitination" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination
is_a: GO:1902916 ! positive regulation of protein polyubiquitination
relationship: positively_regulates GO:0070534 ! protein K63-linked ubiquitination

[Term]
id: GO:1902524
name: positive regulation of protein K48-linked ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of protein K48-linked polyubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein K48-linked ubiquitination" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie]
is_a: GO:0061945 ! regulation of protein K48-linked ubiquitination
is_a: GO:1902916 ! positive regulation of protein polyubiquitination
relationship: positively_regulates GO:0070936 ! protein K48-linked ubiquitination

[Term]
id: GO:1902525
name: regulation of protein monoubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031396 ! regulation of protein ubiquitination
relationship: regulates GO:0006513 ! protein monoubiquitination

[Term]
id: GO:1902526
name: negative regulation of protein monoubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "down regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein monoubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of protein monoubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein monoubiquitylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:1902525 ! regulation of protein monoubiquitination
relationship: negatively_regulates GO:0006513 ! protein monoubiquitination

[Term]
id: GO:1902527
name: positive regulation of protein monoubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of protein monoubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein monoubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein monoubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:1902525 ! regulation of protein monoubiquitination
relationship: positively_regulates GO:0006513 ! protein monoubiquitination

[Term]
id: GO:1902528
name: regulation of protein linear polyubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "regulation of M1 linkage" NARROW [GOC:TermGenie]
is_a: GO:1902914 ! regulation of protein polyubiquitination
relationship: regulates GO:0097039 ! protein linear polyubiquitination

[Term]
id: GO:1902529
name: negative regulation of protein linear polyubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "down regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "down regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "down-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "downregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of M1 linkage" NARROW [GOC:TermGenie]
synonym: "inhibition of protein linear polyubiquitination" NARROW [GOC:TermGenie]
synonym: "negative regulation of M1 linkage" NARROW [GOC:TermGenie]
is_a: GO:1902528 ! regulation of protein linear polyubiquitination
is_a: GO:1902915 ! negative regulation of protein polyubiquitination
relationship: negatively_regulates GO:0097039 ! protein linear polyubiquitination

[Term]
id: GO:1902530
name: positive regulation of protein linear polyubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "activation of protein linear polyubiquitination" NARROW [GOC:TermGenie]
synonym: "positive regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "up regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "up regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "upregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1902528 ! regulation of protein linear polyubiquitination
is_a: GO:1902916 ! positive regulation of protein polyubiquitination
relationship: positively_regulates GO:0097039 ! protein linear polyubiquitination

[Term]
id: GO:1902531
name: regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010627
def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "regulation of intracellular protein kinase cascade" NARROW []
synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0035556 ! intracellular signal transduction

[Term]
id: GO:1902532
name: negative regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010741
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular protein kinase cascade" EXACT []
synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: negatively_regulates GO:0035556 ! intracellular signal transduction

[Term]
id: GO:1902533
name: positive regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010740
def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular protein kinase cascade" NARROW []
synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: positively_regulates GO:0035556 ! intracellular signal transduction

[Term]
id: GO:1902535
name: obsolete multi-organism membrane invagination
namespace: biological_process
def: "OBSOLETE. A membrane invagination which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1902537
name: obsolete multi-organism pinocytosis
namespace: biological_process
def: "OBSOLETE. A pinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1902539
name: obsolete multi-organism macropinocytosis
namespace: biological_process
def: "OBSOLETE. A macropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1902541
name: obsolete multi-organism micropinocytosis
namespace: biological_process
def: "OBSOLETE. A micropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1902542
name: regulation of protein localization to mitotic spindle pole body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626]
synonym: "regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:1902363 ! regulation of protein localization to spindle pole body
relationship: regulates GO:1902440 ! protein localization to mitotic spindle pole body

[Term]
id: GO:1902543
name: negative regulation of protein localization to mitotic spindle pole body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626]
synonym: "down regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to mitotic spindle pole body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to mitotic spindle pole body" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:1902364 ! negative regulation of protein localization to spindle pole body
is_a: GO:1902542 ! regulation of protein localization to mitotic spindle pole body
relationship: negatively_regulates GO:1902440 ! protein localization to mitotic spindle pole body

[Term]
id: GO:1902544
name: obsolete regulation of DNA N-glycosylase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902545
name: obsolete negative regulation of DNA N-glycosylase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA glycosylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA N-glycosylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902546
name: obsolete positive regulation of DNA N-glycosylase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of DNA glycosylase activity" NARROW [GOC:TermGenie]
synonym: "activation of DNA N-glycosylase activity" NARROW [GOC:TermGenie]
synonym: "activation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "upregulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902547
name: regulation of cellular response to vascular endothelial growth factor stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]
synonym: "regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus

[Term]
id: GO:1902548
name: negative regulation of cellular response to vascular endothelial growth factor stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]
comment: ADAMTS12 (UniProt ID P58397) in human in PMID:17895370 inhibits the formation of VEGF-induced tubular structures in BAE-1 cells (endothelial cell line).
synonym: "down regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "down regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to vascular endothelial growth factor" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to vascular endothelial growth factor stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to VEGF" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus
relationship: negatively_regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus

[Term]
id: GO:1902549
name: protein localization to Mei2 nuclear dot
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot." [GOC:TermGenie, PMID:23980030]
synonym: "protein localisation in Mei2 nuclear dot" EXACT [GOC:TermGenie]
synonym: "protein localisation to Mei2 nuclear dot" EXACT [GOC:TermGenie]
synonym: "protein localization in Mei2 nuclear dot" EXACT [GOC:TermGenie]
synonym: "protein localization to Mei2 dot" EXACT []
is_a: GO:0034504 ! protein localization to nucleus

[Term]
id: GO:1902550
name: lymphoid lineage cell migration into thymus involved in thymus epithelium morphogenesis
namespace: biological_process
def: "Any lymphoid lineage cell migration into thymus that is involved in thymus epithelium morphogenesis." [GOC:cvs, GOC:TermGenie, PMID:22342843]
synonym: "lymphoid lineage cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymus epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0097535 ! lymphoid lineage cell migration into thymus
relationship: part_of GO:0097536 ! thymus epithelium morphogenesis

[Term]
id: GO:1902551
name: regulation of catalase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797]
subset: gocheck_obsoletion_candidate
synonym: "regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CAT" RELATED [GOC:TermGenie]
synonym: "regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "regulation of optidase activity" EXACT [GOC:TermGenie]
is_a: GO:2000468 ! regulation of peroxidase activity

[Term]
id: GO:1902552
name: obsolete negative regulation of catalase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CAT" RELATED [GOC:TermGenie]
synonym: "down regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "down regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CAT" RELATED [GOC:TermGenie]
synonym: "down-regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CAT" RELATED [GOC:TermGenie]
synonym: "downregulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "downregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of caperase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CAT" RELATED [GOC:TermGenie]
synonym: "inhibition of catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of catalase reaction" NARROW [GOC:TermGenie]
synonym: "inhibition of catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of equilase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of optidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CAT" RELATED [GOC:TermGenie]
synonym: "negative regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "negative regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of optidase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902553
name: positive regulation of catalase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797]
subset: gocheck_obsoletion_candidate
synonym: "activation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of caperase activity" NARROW [GOC:TermGenie]
synonym: "activation of CAT" RELATED [GOC:TermGenie]
synonym: "activation of catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of catalase reaction" NARROW [GOC:TermGenie]
synonym: "activation of catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of equilase activity" NARROW [GOC:TermGenie]
synonym: "activation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of optidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CAT" RELATED [GOC:TermGenie]
synonym: "positive regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "positive regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CAT" RELATED [GOC:TermGenie]
synonym: "up regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "up regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CAT" RELATED [GOC:TermGenie]
synonym: "up-regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CAT" RELATED [GOC:TermGenie]
synonym: "upregulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "upregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of optidase activity" EXACT [GOC:TermGenie]
is_a: GO:1902551 ! regulation of catalase activity
is_a: GO:2000470 ! positive regulation of peroxidase activity

[Term]
id: GO:1902554
name: serine/threonine protein kinase complex
namespace: cellular_component
def: "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]
comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay).
synonym: "PDR16 complex dimer" RELATED []
synonym: "PDR16 complex homodimer" RELATED []
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:1902555
name: endoribonuclease complex
namespace: cellular_component
def: "A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]
is_a: GO:1905348 ! endonuclease complex

[Term]
id: GO:1902556
name: phosphatidylinositol transporter complex
namespace: cellular_component
def: "A protein complex which is capable of phosphatidylinositol transporter activity." [GOC:bhm, GOC:TermGenie, PMID:9890948]
comment: An example is PDR16 in S. cerevisiae (UniProt ID P53860) in PMID:9890948 (inferred from direct assay).
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:1902557
name: 5'-adenylyl sulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other." [GOC:TermGenie, PMID:24296033]
comment: An example of this is the YPR011C gene product in S. cerevisiae in PMID:24296033.
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:1902558
name: 5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The process in which 5'-adenylyl sulfate is transported across a membrane." [GOC:TermGenie, PMID:24296033]
synonym: "adenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:1902559
name: 3'-phospho-5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a membrane." [GOC:TermGenie, PMID:24296033]
synonym: "3'-phosphoadenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033]
is_a: GO:0046963 ! 3'-phosphoadenosine 5'-phosphosulfate transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:1902560
name: GMP reductase complex
namespace: cellular_component
def: "An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H+ + NADPH => IMP + NADP+ + NH4." [GOC:bhm, GOC:TermGenie, PMID:12009299]
comment: An example of this is GMPR2 in human (UniProt Symbol Q9P2T1) in PMID:12009299 (inferred from direct assay).
synonym: "GMP reductase" NARROW []
synonym: "GMPR1 complex" NARROW []
synonym: "GMPR2 complex" NARROW []
synonym: "guanosine monophosphate reductase" NARROW []
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1902561
name: origin recognition complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an origin recognition complex." [GOC:TermGenie, PMID:11717425]
synonym: "ORC assembly" EXACT [GOC:TermGenie]
synonym: "ORC formation" EXACT [GOC:TermGenie]
synonym: "origin of replication recognition complex assembly" EXACT [GOC:TermGenie]
synonym: "origin of replication recognition complex formation" EXACT [GOC:TermGenie]
synonym: "origin recognition complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1902562
name: H4 histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086]
comment: An example of this is Hpa2 in yeast [Q06592] in PMID:23775086 [IDA].
synonym: "Hpa3 (homo-)dimer" NARROW [PMID:23775086]
synonym: "Hpa3 complex" NARROW [PMID:23775086]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:1902563
name: regulation of neutrophil activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0042119 ! neutrophil activation

[Term]
id: GO:1902564
name: negative regulation of neutrophil activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661]
synonym: "down regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "downregulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "inhibition of neutrophil activation" NARROW [GOC:TermGenie]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:1902563 ! regulation of neutrophil activation
relationship: negatively_regulates GO:0042119 ! neutrophil activation

[Term]
id: GO:1902565
name: positive regulation of neutrophil activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661]
synonym: "activation of neutrophil activation" NARROW [GOC:TermGenie]
synonym: "up regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "upregulation of neutrophil activation" EXACT [GOC:TermGenie]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:1902563 ! regulation of neutrophil activation
relationship: positively_regulates GO:0042119 ! neutrophil activation

[Term]
id: GO:1902566
name: regulation of eosinophil activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0043307 ! eosinophil activation

[Term]
id: GO:1902567
name: negative regulation of eosinophil activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138]
synonym: "down regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "downregulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "inhibition of eosinophil activation" NARROW [GOC:TermGenie]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:1902566 ! regulation of eosinophil activation
relationship: negatively_regulates GO:0043307 ! eosinophil activation

[Term]
id: GO:1902568
name: positive regulation of eosinophil activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138]
synonym: "activation of eosinophil activation" NARROW [GOC:TermGenie]
synonym: "up regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "upregulation of eosinophil activation" EXACT [GOC:TermGenie]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:1902566 ! regulation of eosinophil activation
relationship: positively_regulates GO:0043307 ! eosinophil activation

[Term]
id: GO:1902569
name: obsolete negative regulation of activation of Janus kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity." [GOC:TermGenie, PMID:16254138]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of activation of JAK1 kinase activity" NARROW []
synonym: "down regulation of activation of JAK1 protein" NARROW []
synonym: "down regulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of activation of JAK2 protein" NARROW [GOC:TermGenie]
synonym: "down regulation of tyrosine phosphorylation of JAK1 protein" NARROW []
synonym: "down regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
synonym: "down-regulation of activation of JAK1 kinase activity" NARROW []
synonym: "down-regulation of activation of JAK1 protein" NARROW []
synonym: "down-regulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of JAK2 protein" NARROW [GOC:TermGenie]
synonym: "down-regulation of tyrosine phosphorylation of JAK1 protein" NARROW []
synonym: "down-regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of JAK1 kinase activity" NARROW []
synonym: "downregulation of activation of JAK1 protein" NARROW []
synonym: "downregulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of tyrosine phosphorylation of JAK1 protein" NARROW []
synonym: "downregulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
synonym: "inhibition of activation of JAK1 kinase activity" NARROW []
synonym: "inhibition of activation of JAK1 protein" NARROW []
synonym: "inhibition of activation of JAK2 kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of JAK2 protein" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine phosphorylation of JAK1 protein" NARROW []
synonym: "inhibition of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
synonym: "negative regulation of activation of JAK1 protein" NARROW []
synonym: "negative regulation of activation of JAK2 kinase activity" NARROW []
synonym: "negative regulation of activation of JAK2 protein" NARROW [GOC:TermGenie]
synonym: "negative regulation of tyrosine phosphorylation of JAK1 protein" NARROW []
synonym: "negative regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0046426

[Term]
id: GO:1902570
name: protein localization to nucleolus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626]
synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus

[Term]
id: GO:1902571
name: regulation of serine-type peptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351]
subset: gocheck_obsoletion_candidate
synonym: "regulation of serine protease activity" NARROW [GOC:TermGenie]
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:1902572
name: negative regulation of serine-type peptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "down regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "downregulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of serine protease activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine-type peptidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of serine protease activity" NARROW [GOC:TermGenie]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:1902571 ! regulation of serine-type peptidase activity

[Term]
id: GO:1902573
name: positive regulation of serine-type peptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351]
subset: gocheck_obsoletion_candidate
synonym: "activation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "activation of serine-type peptidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "upregulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:1902571 ! regulation of serine-type peptidase activity

[Term]
id: GO:1902574
name: obsolete negative regulation of leucine import by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of leucine import." [GOC:TermGenie, PMID:22992726]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1902575
name: protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any protein localization to cell division site that is involved in cytokinesis, actomyosin contractile ring assembly." [GOC:al, GOC:TermGenie, PMID:24127216]
synonym: "protein localisation to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie]
synonym: "protein localization to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0072741 ! protein localization to cell division site
relationship: part_of GO:0000915 ! actomyosin contractile ring assembly

[Term]
id: GO:1902576
name: negative regulation of nuclear cell cycle DNA replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication." [GOC:TermGenie, PMID:19033384]
synonym: "down regulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S phase" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S-phase" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
is_a: GO:2000104 ! negative regulation of DNA-templated DNA replication
relationship: negatively_regulates GO:0033260 ! nuclear DNA replication

[Term]
id: GO:1902577
name: protein localization to medial cortical node
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a medial cortical node." [GOC:TermGenie, PMID:24127216]
synonym: "protein localisation in medial cortical node" EXACT [GOC:TermGenie]
synonym: "protein localisation to medial cortical node" EXACT [GOC:TermGenie]
synonym: "protein localization in medial cortical node" EXACT [GOC:TermGenie]
is_a: GO:0071574 ! protein localization to medial cortex

[Term]
id: GO:1902579
name: obsolete multi-organism localization
namespace: biological_process
def: "OBSOLETE. A localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi organism localization" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902581
name: obsolete multi-organism cellular localization
namespace: biological_process
def: "OBSOLETE. A cellular localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi organism cellular localization" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902583
name: obsolete multi-organism intracellular transport
namespace: biological_process
def: "OBSOLETE. An intracellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi organism intracellular transport" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902584
name: positive regulation of response to water deprivation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to water deprivation." [GO_REF:0000058, GOC:TermGenie, PMID:24198318]
synonym: "activation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "activation of response to dehydration" NARROW [GOC:TermGenie]
synonym: "activation of response to drought" NARROW [GOC:TermGenie]
synonym: "activation of response to thirst" NARROW [GOC:TermGenie]
synonym: "activation of response to water deprivation" NARROW [GOC:TermGenie]
synonym: "positive regulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to drought" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "up regulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "up regulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "up regulation of response to drought" EXACT [GOC:TermGenie]
synonym: "up regulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "up regulation of response to water deprivation" EXACT [GOC:TermGenie]
synonym: "up-regulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to drought" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to water deprivation" EXACT [GOC:TermGenie]
synonym: "upregulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "upregulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "upregulation of response to drought" EXACT [GOC:TermGenie]
synonym: "upregulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "upregulation of response to water deprivation" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2000070 ! regulation of response to water deprivation
relationship: positively_regulates GO:0009414 ! response to water deprivation

[Term]
id: GO:1902586
name: obsolete multi-organism intercellular transport
namespace: biological_process
def: "OBSOLETE. An intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi organism intercellular transport" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902588
name: obsolete multi-organism plasmodesmata-mediated intercellular transport
namespace: biological_process
def: "OBSOLETE. A plasmodesmata-mediated intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi organism plasmodesmata-mediated intercellular transport" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902590
name: obsolete multi-organism organelle organization
namespace: biological_process
def: "OBSOLETE. An organelle organization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi organism organelle organization" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902592
name: obsolete multi-organism membrane budding
namespace: biological_process
def: "OBSOLETE. A membrane budding which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: Obsoleted because it was a grouping term for a viral process that was incorrectly under 'multi-organism cellular process'. The children terms have been moved under 'viral process', so that this grouping term is not necessary anymore.
synonym: "multi organism membrane budding" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902594
name: obsolete multi-organism nuclear import
namespace: biological_process
def: "OBSOLETE. A nuclear import which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "multi organism nuclear import" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902595
name: regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
subset: gocheck_do_not_annotate
synonym: "regulation of ARS binding" NARROW [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:1902596
name: negative regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
subset: gocheck_do_not_annotate
synonym: "down regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of ARS binding" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication origin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of ARS binding" NARROW [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1902595 ! regulation of DNA replication origin binding

[Term]
id: GO:1902597
name: positive regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
subset: gocheck_do_not_annotate
synonym: "activation of ARS binding" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication origin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA replication origin binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1902595 ! regulation of DNA replication origin binding

[Term]
id: GO:1902599
name: sulfathiazole transmembrane transport
namespace: biological_process
alt_id: GO:0015906
def: "The directed movement of sulfathiazole across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "sulfathiazole transport" BROAD []
synonym: "sulphathiazole transport" BROAD []
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:1902600
name: proton transmembrane transport
namespace: biological_process
alt_id: GO:0006818
alt_id: GO:0015991
alt_id: GO:0015992
def: "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
subset: goslim_pir
synonym: "ATP hydrolysis coupled proton transport" NARROW []
synonym: "hydrogen ion transmembrane transport" EXACT []
synonym: "hydrogen ion transport" RELATED []
synonym: "hydrogen transmembrane transport" EXACT []
synonym: "hydrogen transport" BROAD []
synonym: "passive proton transport, down the electrochemical gradient" NARROW []
synonym: "proton transport" BROAD []
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:1902601
name: silver ion transmembrane transport
namespace: biological_process
def: "The directed movement of silver (Ag+) ions across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "silver transmembrane transport" BROAD []
is_a: GO:0015673 ! silver ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:1902602
name: aluminum ion transmembrane transport
namespace: biological_process
def: "The directed movement of aluminium ions across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "aluminium ion transmembrane transport" EXACT []
synonym: "aluminium transmembrane transport" BROAD []
synonym: "aluminum transmembrane transport" BROAD []
is_a: GO:0098660 ! inorganic ion transmembrane transport

[Term]
id: GO:1902603
name: carnitine transmembrane transport
namespace: biological_process
def: "The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
is_a: GO:0015879 ! carnitine transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1902604
name: p-aminobenzoyl-glutamate transmembrane transport
namespace: biological_process
def: "The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "N-(4-aminobenzoyl)-L-glutamate transmembrane transport" EXACT []
is_a: GO:0015814 ! p-aminobenzoyl-glutamate transport
is_a: GO:0035442 ! dipeptide transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1902605
name: heterotrimeric G-protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:23637185]
synonym: "heterotrimeric G-protein complex formation" EXACT [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase activity assembly" RELATED [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase activity formation" RELATED [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, alpha-subunit assembly" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, alpha-subunit formation" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, beta-subunit assembly" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, beta-subunit formation" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, gamma-subunit assembly" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, gamma-subunit formation" NARROW [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1902606
name: regulation of large conductance calcium-activated potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708]
subset: gocheck_obsoletion_candidate
synonym: "regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1902607
name: negative regulation of large conductance calcium-activated potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "down regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "down regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "down-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "down-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "downregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "downregulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "downregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "inhibition of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of BK channel activity" RELATED [GOC:TermGenie]
synonym: "inhibition of BK KCa channels" NARROW [GOC:TermGenie]
synonym: "inhibition of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of large conductance KCa channels" NARROW [GOC:TermGenie]
synonym: "negative regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "negative regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity
is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity
is_a: GO:2001258 ! negative regulation of cation channel activity

[Term]
id: GO:1902608
name: positive regulation of large conductance calcium-activated potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708]
subset: gocheck_obsoletion_candidate
synonym: "activation of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "activation of BK KCa channels" NARROW [GOC:TermGenie]
synonym: "activation of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of large conductance KCa channels" NARROW [GOC:TermGenie]
synonym: "positive regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "positive regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "up regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "up regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "up regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "up-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "up-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "upregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "upregulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "upregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of large conductance KCa channels" EXACT [GOC:TermGenie]
is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity
is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:1902609
name: (R)-2-hydroxy-alpha-linolenic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (R)-2-hydroxy-alpha-linolenic acid." [GO_REF:0000068, GOC:TermGenie, PMID:24214535]
synonym: "(R)-2-hydroxy-alpha-linolenic acid anabolism" EXACT [GOC:TermGenie]
synonym: "(R)-2-hydroxy-alpha-linolenic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "(R)-2-hydroxy-alpha-linolenic acid formation" EXACT [GOC:TermGenie]
synonym: "(R)-2-hydroxy-alpha-linolenic acid synthesis" EXACT [GOC:TermGenie]
synonym: "2-hydroxy-octadecatrienoic acid biosynthesis" BROAD []
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:1902610
name: response to N-phenylthiourea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1902611
name: cellular response to N-phenylthiourea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902610 ! response to N-phenylthiourea

[Term]
id: GO:1902612
name: regulation of anti-Mullerian hormone signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:1990262 ! anti-Mullerian hormone receptor signaling pathway

[Term]
id: GO:1902613
name: negative regulation of anti-Mullerian hormone signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]
synonym: "down regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway
relationship: negatively_regulates GO:1990262 ! anti-Mullerian hormone receptor signaling pathway

[Term]
id: GO:1902614
name: positive regulation of anti-Mullerian hormone signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]
synonym: "activation of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway
relationship: positively_regulates GO:1990262 ! anti-Mullerian hormone receptor signaling pathway

[Term]
id: GO:1902615
name: immune response involved in response to exogenous dsRNA
namespace: biological_process
def: "Any immune response that is involved in response to exogenous dsRNA." [GO_REF:0000060, GOC:pg, GOC:TermGenie, PMID:21266579]
synonym: "immune response involved in response to exogenous double-stranded RNA" EXACT [GOC:TermGenie]
synonym: "immune response involved in response to viral dsRNA" NARROW [GOC:TermGenie]
is_a: GO:0006955 ! immune response
relationship: part_of GO:0043330 ! response to exogenous dsRNA

[Term]
id: GO:1902616
name: acyl carnitine transmembrane transport
namespace: biological_process
def: "The process in which acyl carnitine is transported across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "O-acylcarnitine transmembrane transport" EXACT []
is_a: GO:0006844 ! acyl carnitine transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1902617
name: response to fluoride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1902618
name: cellular response to fluoride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902617 ! response to fluoride

[Term]
id: GO:1902619
name: regulation of microtubule minus-end binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]
subset: gocheck_do_not_annotate
is_a: GO:1904526 ! regulation of microtubule binding

[Term]
id: GO:1902620
name: positive regulation of microtubule minus-end binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]
subset: gocheck_do_not_annotate
synonym: "activation of microtubule minus-end binding" NARROW [GOC:TermGenie]
synonym: "up regulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
is_a: GO:1902619 ! regulation of microtubule minus-end binding
is_a: GO:1904528 ! positive regulation of microtubule binding

[Term]
id: GO:1902621
name: obsolete actomyosin contractile ring disassembly
namespace: biological_process
def: "OBSOLETE. The disaggregation of an actomyosin contractile ring into its constituent components." [PMID:14602073, PMID:22891673]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
is_obsolete: true

[Term]
id: GO:1902622
name: regulation of neutrophil migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836]
is_a: GO:0002685 ! regulation of leukocyte migration
relationship: regulates GO:1990266 ! neutrophil migration

[Term]
id: GO:1902623
name: negative regulation of neutrophil migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836]
synonym: "down regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "downregulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "inhibition of neutrophil migration" NARROW [GOC:TermGenie]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:1902622 ! regulation of neutrophil migration
relationship: negatively_regulates GO:1990266 ! neutrophil migration

[Term]
id: GO:1902624
name: positive regulation of neutrophil migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836]
synonym: "activation of neutrophil migration" NARROW [GOC:TermGenie]
synonym: "up regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "upregulation of neutrophil migration" EXACT [GOC:TermGenie]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:1902622 ! regulation of neutrophil migration
relationship: positively_regulates GO:1990266 ! neutrophil migration

[Term]
id: GO:1902625
name: obsolete negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:9671458]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1902626
name: assembly of large subunit precursor of preribosome
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:22735702]
synonym: "66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of GO:0000027 ! ribosomal large subunit assembly

[Term]
id: GO:1902627
name: regulation of assembly of large subunit precursor of preribosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702]
synonym: "regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1902626 ! assembly of large subunit precursor of preribosome

[Term]
id: GO:1902628
name: positive regulation of assembly of large subunit precursor of preribosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702]
synonym: "activation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "activation of assembly of large subunit precursor of preribosome" NARROW [GOC:TermGenie]
synonym: "activation of preribosome, large subunit precursor formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "up regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie]
synonym: "up regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "upregulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie]
synonym: "upregulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1902627 ! regulation of assembly of large subunit precursor of preribosome
relationship: positively_regulates GO:1902626 ! assembly of large subunit precursor of preribosome

[Term]
id: GO:1902629
name: regulation of mRNA stability involved in cellular response to UV
namespace: biological_process
def: "Any regulation of mRNA stability that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:10954610]
synonym: "regulation of mRNA stability involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA stability involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA stability involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA stability involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie]
is_a: GO:0043488 ! regulation of mRNA stability
relationship: part_of GO:0034644 ! cellular response to UV

[Term]
id: GO:1902630
name: regulation of membrane hyperpolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304]
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0060081 ! membrane hyperpolarization

[Term]
id: GO:1902631
name: negative regulation of membrane hyperpolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304]
synonym: "down regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane hyperpolarization" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1902630 ! regulation of membrane hyperpolarization
relationship: negatively_regulates GO:0060081 ! membrane hyperpolarization

[Term]
id: GO:1902632
name: positive regulation of membrane hyperpolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304]
synonym: "activation of membrane hyperpolarization" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1902630 ! regulation of membrane hyperpolarization
relationship: positively_regulates GO:0060081 ! membrane hyperpolarization

[Term]
id: GO:1902633
name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]
comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name.
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:1902634
name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]
comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name.
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0031161 ! phosphatidylinositol catabolic process
is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process

[Term]
id: GO:1902635
name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "phosphatidylinositol-4,5-bisphosphate biosynthesis" EXACT []
synonym: "PtdIns(4,5)P(2) biosynthesis" EXACT []
is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process
is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process

[Term]
id: GO:1902636
name: kinociliary basal body
namespace: cellular_component
def: "A ciliary basal body that is part of a kinocilium." [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574]
synonym: "cilial basal body of kinocilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of kinocilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of kinocilium" EXACT [GOC:TermGenie]
synonym: "kinocilial basal body" EXACT []
synonym: "kinocilium basal body" EXACT []
synonym: "kinocilium ciliary basal body" EXACT []
synonym: "microtubule basal body of kinocilium" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0060091 ! kinocilium

[Term]
id: GO:1902637
name: neural crest cell differentiation involved in thymus development
namespace: biological_process
def: "Any neural crest cell differentiation that is involved in thymus development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317, PMID:18292542]
is_a: GO:0014033 ! neural crest cell differentiation
relationship: part_of GO:0048538 ! thymus development

[Term]
id: GO:1902638
name: neural crest cell differentiation involved in parathyroid gland development
namespace: biological_process
def: "Any neural crest cell differentiation that is involved in parathyroid gland development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317]
is_a: GO:0014033 ! neural crest cell differentiation
relationship: part_of GO:0060017 ! parathyroid gland development

[Term]
id: GO:1902639
name: propan-2-ol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237]
synonym: "Isopropanol metabolic process" EXACT []
synonym: "Isopropyl alcohol metabolic process" EXACT []
synonym: "propan-2-ol metabolism" EXACT [GOC:TermGenie]
is_a: GO:1902652 ! secondary alcohol metabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:1902640
name: propan-2-ol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237]
synonym: "Isopropanol biosynthetic process" EXACT []
synonym: "Isopropyl alcohol biosynthetic process" EXACT []
synonym: "propan-2-ol anabolism" EXACT [GOC:TermGenie]
synonym: "propan-2-ol biosynthesis" EXACT [GOC:TermGenie]
synonym: "propan-2-ol formation" EXACT [GOC:TermGenie]
synonym: "propan-2-ol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902639 ! propan-2-ol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
is_a: GO:1903175 ! fatty alcohol biosynthetic process

[Term]
id: GO:1902641
name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0060696 ! regulation of phospholipid catabolic process
relationship: regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process

[Term]
id: GO:1902642
name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
relationship: negatively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process

[Term]
id: GO:1902643
name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0060697 ! positive regulation of phospholipid catabolic process
is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
relationship: positively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process

[Term]
id: GO:1902644
name: tertiary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "tertiary alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:1902645
name: tertiary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "tertiary alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "tertiary alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "tertiary alcohol formation" EXACT [GOC:TermGenie]
synonym: "tertiary alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:1902646
name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
relationship: regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

[Term]
id: GO:1902647
name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010512 ! negative regulation of phosphatidylinositol biosynthetic process
is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
relationship: negatively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

[Term]
id: GO:1902648
name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010513 ! positive regulation of phosphatidylinositol biosynthetic process
is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
relationship: positively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

[Term]
id: GO:1902649
name: obsolete regulation of histone H2A-H2B dimer displacement
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0140713

[Term]
id: GO:1902650
name: obsolete negative regulation of histone H2A-H2B dimer displacement
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0140713

[Term]
id: GO:1902651
name: obsolete positive regulation of histone H2A-H2B dimer displacement
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0140713

[Term]
id: GO:1902652
name: secondary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "secondary alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:1902653
name: secondary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "secondary alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "secondary alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "secondary alcohol formation" EXACT [GOC:TermGenie]
synonym: "secondary alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:1902654
name: aromatic primary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878]
synonym: "aromatic primary alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:1902655
name: aromatic primary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878]
synonym: "aromatic primary alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "aromatic primary alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "aromatic primary alcohol formation" EXACT [GOC:TermGenie]
synonym: "aromatic primary alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1902654 ! aromatic primary alcohol metabolic process

[Term]
id: GO:1902656
name: calcium ion import into cytosol
namespace: biological_process
def: "The directed movement of calcium ion into a cytosol." [GO_REF:0000075, GOC:TermGenie, GOC:vw]
synonym: "calcium import into cytosol" BROAD []
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:1902657
name: protein localization to prospore membrane
namespace: biological_process
alt_id: GO:0072693
alt_id: GO:1902658
def: "A process in which a protein is transported to, or maintained in, a location within a prospore membrane." [GO_REF:0000087, GOC:dph, GOC:TermGenie, PMID:24036347]
synonym: "establishment of protein localisation in prospore membrane" RELATED [GOC:TermGenie]
synonym: "establishment of protein localisation to prospore membrane" RELATED [GOC:TermGenie]
synonym: "establishment of protein localization in prospore membrane" RELATED [GOC:TermGenie]
synonym: "establishment of protein localization to prospore membrane" RELATED []
synonym: "protein localisation in prospore membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to prospore membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in prospore membrane" EXACT [GOC:TermGenie]
synonym: "protein targeting to ascospore-type prospore membrane" RELATED [GOC:mah]
synonym: "protein targeting to forespore membrane" RELATED [GOC:mah]
synonym: "protein targeting to FSM" RELATED [GOC:mah]
synonym: "protein targeting to prospore membrane" RELATED []
synonym: "protein-prospore membrane targeting" RELATED [GOC:mah]
is_a: GO:0072657 ! protein localization to membrane

[Term]
id: GO:1902659
name: regulation of glucose mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]
synonym: "regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0010255 ! glucose mediated signaling pathway

[Term]
id: GO:1902660
name: negative regulation of glucose mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]
synonym: "down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902659 ! regulation of glucose mediated signaling pathway
relationship: negatively_regulates GO:0010255 ! glucose mediated signaling pathway

[Term]
id: GO:1902661
name: positive regulation of glucose mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]
synonym: "activation of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902659 ! regulation of glucose mediated signaling pathway
relationship: positively_regulates GO:0010255 ! glucose mediated signaling pathway

[Term]
id: GO:1902662
name: regulation of peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136]
subset: gocheck_obsoletion_candidate
synonym: "regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
is_a: GO:1903059 ! regulation of protein lipidation
relationship: regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation

[Term]
id: GO:1902663
name: negative regulation of peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "negative regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation
is_a: GO:1903060 ! negative regulation of protein lipidation
relationship: negatively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation

[Term]
id: GO:1902664
name: positive regulation of peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136]
subset: gocheck_obsoletion_candidate
synonym: "activation of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "positive regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation
is_a: GO:1903061 ! positive regulation of protein lipidation
relationship: positively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation

[Term]
id: GO:1902665
name: response to isobutanol
namespace: biological_process
alt_id: GO:1990337
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isobutanol stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:24014527]
synonym: "process resulting in tolerance to isobutanol" NARROW []
synonym: "response to 2-methylpropan-1-ol" EXACT [GOC:mengo_curators]
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:1902666
name: obsolete protein localization to Mmi1 nuclear focus complex
namespace: biological_process
def: "OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a Mmi1 nuclear focus complex." [GO_REF:0000087, GOC:TermGenie, PMID:23980030]
comment: This term was obsoleted because there is no evidence that this process exists (no factor mediates the localization of proteins to Mmi1 nuclear foci)
synonym: "protein localisation in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie]
synonym: "protein localisation to Mmi1 nuclear focus complex" EXACT [GOC:TermGenie]
synonym: "protein localization in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902667
name: regulation of axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]
synonym: "regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "regulation of axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0007411 ! axon guidance

[Term]
id: GO:1902668
name: negative regulation of axon guidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]
synonym: "down regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "down regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "down regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "down-regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "down-regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "downregulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "downregulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "downregulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "inhibition of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "inhibition of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of axon pathfinding" NARROW [GOC:TermGenie]
synonym: "negative regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "negative regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "negative regulation of axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1902667 ! regulation of axon guidance
relationship: negatively_regulates GO:0007411 ! axon guidance

[Term]
id: GO:1902669
name: positive regulation of axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]
synonym: "activation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "activation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "activation of axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of axon pathfinding" NARROW [GOC:TermGenie]
synonym: "positive regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "positive regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "positive regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "up regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "up regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "up-regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "up-regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "upregulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "upregulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "upregulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:1902667 ! regulation of axon guidance
relationship: positively_regulates GO:0007411 ! axon guidance

[Term]
id: GO:1902670
name: carbon dioxide binding
namespace: molecular_function
def: "Binding to carbon dioxide." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:15491402]
synonym: "CO2 binding" EXACT []
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:1902671
name: left anterior basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left anterior flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left anterior flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left anterior flagellum" EXACT [GOC:TermGenie]
synonym: "left anterior flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left anterior flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097554 ! left anterior flagellum

[Term]
id: GO:1902672
name: right anterior basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "right anterior flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097555 ! right anterior flagellum

[Term]
id: GO:1902673
name: left posteriolateral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "left posteriolateral flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097556 ! left posteriolateral flagellum

[Term]
id: GO:1902674
name: right posteriolateral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "right posteriolateral flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097557 ! right posteriolateral flagellum

[Term]
id: GO:1902675
name: left ventral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left ventral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left ventral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left ventral flagellum" EXACT [GOC:TermGenie]
synonym: "left ventral flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left ventral flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097558 ! left ventral flagellum

[Term]
id: GO:1902676
name: right ventral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "right ventral flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097559 ! right ventral flagellum

[Term]
id: GO:1902677
name: left caudal basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left caudal flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left caudal flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left caudal flagellum" EXACT [GOC:TermGenie]
synonym: "left caudal flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left caudal flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097560 ! left caudal flagellum

[Term]
id: GO:1902678
name: right caudal basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "right caudal flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
relationship: part_of GO:0097561 ! right caudal flagellum

[Term]
id: GO:1902679
name: negative regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process

[Term]
id: GO:1902680
name: positive regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of RNA formation" NARROW [GOC:TermGenie]
synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
relationship: positively_regulates GO:0032774 ! RNA biosynthetic process

[Term]
id: GO:1902681
name: regulation of replication fork arrest at rDNA repeats
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats." [GO_REF:0000058, GOC:TermGenie, PMID:23260662]
synonym: "regulation of replication fork arrest at ribosomal DNA repeats" EXACT [GOC:TermGenie]
synonym: "regulation of replication fork blocking at rDNA repeats" EXACT [GOC:TermGenie]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
relationship: regulates GO:0031582 ! replication fork arrest at rDNA repeats

[Term]
id: GO:1902682
name: protein localization to pericentric heterochromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in the pericentric heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20211136]
synonym: "protein localisation in centromeric heterochromatin" EXACT [GOC:TermGenie]
is_a: GO:0071459 ! protein localization to chromosome, centromeric region
is_a: GO:0097355 ! protein localization to heterochromatin

[Term]
id: GO:1902683
name: regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0097120 ! receptor localization to synapse

[Term]
id: GO:1902684
name: negative regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "down regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor localisation to synapse" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor localization to synapse" NARROW [GOC:TermGenie]
synonym: "negative regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1902683 ! regulation of receptor localization to synapse
relationship: negatively_regulates GO:0097120 ! receptor localization to synapse

[Term]
id: GO:1902685
name: positive regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "activation of receptor localisation to synapse" NARROW [GOC:TermGenie]
synonym: "activation of receptor localization to synapse" NARROW [GOC:TermGenie]
synonym: "positive regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor localization to synapse" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1902683 ! regulation of receptor localization to synapse
relationship: positively_regulates GO:0097120 ! receptor localization to synapse

[Term]
id: GO:1902686
name: mitochondrial outer membrane permeabilization involved in programmed cell death
namespace: biological_process
def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie, PMID:20151314]
synonym: "mitochondrial membrane permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in PCD" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in PCD" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial outer membrane permeabilization during programmed cell death" EXACT []
synonym: "mitochondrial permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in PCD" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrion outer membrane permeabilization involved in programmed cell death" EXACT []
synonym: "MPT involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "MPT involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in PCD" NARROW [GOC:TermGenie]
synonym: "MPT involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in PCD" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death" EXACT []
synonym: "positive regulation of mitochondrial membrane permeability involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in PCD" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in regulated cell death" RELATED [GOC:TermGenie]
is_a: GO:0035794 ! positive regulation of mitochondrial membrane permeability
relationship: part_of GO:0012501 ! programmed cell death

[Term]
id: GO:1902687
name: glucosidase complex
namespace: cellular_component
def: "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932]
comment: An example of this is ygjK in E. coli (P42592) in PMID:23826932.
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1902688
name: regulation of NAD metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]
synonym: "regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
relationship: regulates GO:0019674 ! NAD metabolic process

[Term]
id: GO:1902689
name: negative regulation of NAD metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]
synonym: "down regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "down regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "down-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "downregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD (oxidized) metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized NAD metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
is_a: GO:1902688 ! regulation of NAD metabolic process
relationship: negatively_regulates GO:0019674 ! NAD metabolic process

[Term]
id: GO:1902690
name: positive regulation of NAD metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]
synonym: "activation of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of NAD (oxidized) metabolism" NARROW [GOC:TermGenie]
synonym: "activation of NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of NAD metabolism" NARROW [GOC:TermGenie]
synonym: "activation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "activation of oxidized NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of oxidized NAD metabolism" NARROW [GOC:TermGenie]
synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "up regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "up-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "upregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
is_a: GO:1902688 ! regulation of NAD metabolic process
relationship: positively_regulates GO:0019674 ! NAD metabolic process

[Term]
id: GO:1902691
name: respiratory basal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell." [GO_REF:0000086, GOC:TermGenie, MP:0011114, PMID:17909629]
comment: Changes in the lineage choice of ABCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders
synonym: "airway basal cell differentiation" EXACT [MP:0011114]
is_a: GO:0048863 ! stem cell differentiation

[Term]
id: GO:1902692
name: regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
relationship: regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:1902693
name: superoxide dismutase complex
namespace: cellular_component
def: "A protein complex which is capable of superoxide dismutase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10026301]
comment: An example of this is SOD1 in Saccharomyces cerevisiae S288c (UniProt symbol P00445) in PMID:10026301.
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1902694
name: superoxide dismutase copper chaperone complex
namespace: cellular_component
def: "A protein complex which is capable of superoxide dismutase copper chaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947]
comment: An example of this is CCS1 in Saccharomyces cerevisiae S288c (UniProt symbol P40202) in PMID:10426947.
is_a: GO:1902695 ! metallochaperone complex

[Term]
id: GO:1902695
name: metallochaperone complex
namespace: cellular_component
def: "A protein complex which is capable of metallochaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1902696
name: glycine catabolic process to isobutanol
namespace: biological_process
alt_id: GO:1990293
def: "The chemical reactions and pathways resulting in the breakdown of glycine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:23642236]
synonym: "glycine breakdown to isobutanol" EXACT [GOC:TermGenie]
synonym: "glycine catabolism to isobutanol" EXACT [GOC:TermGenie]
synonym: "glycine degradation to isobutanol" EXACT [GOC:TermGenie]
is_a: GO:0006546 ! glycine catabolic process
is_a: GO:1901960 ! isobutanol metabolic process

[Term]
id: GO:1902697
name: valine catabolic process to isobutanol
namespace: biological_process
alt_id: GO:1990292
def: "The chemical reactions and pathways resulting in the breakdown of valine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:9748245]
synonym: "valine breakdown to isobutanol" EXACT [GOC:TermGenie]
synonym: "valine catabolism to isobutanol" EXACT [GOC:TermGenie]
synonym: "valine degradation to isobutanol" EXACT [GOC:TermGenie]
is_a: GO:0006574 ! valine catabolic process
is_a: GO:1901960 ! isobutanol metabolic process

[Term]
id: GO:1902698
name: obsolete pentose catabolic process to butyrate
namespace: biological_process
alt_id: GO:1990288
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of pentose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "pentose breakdown to butyrate" EXACT [GOC:TermGenie]
synonym: "pentose catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "pentose degradation to butyrate" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902699
name: obsolete pentose catabolic process to acetate
namespace: biological_process
alt_id: GO:1990289
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of pentose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "pentose breakdown to acetate" EXACT [GOC:TermGenie]
synonym: "pentose catabolism to acetate" EXACT [GOC:TermGenie]
synonym: "pentose degradation to acetate" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902700
name: obsolete pentose catabolic process to butan-1-ol
namespace: biological_process
alt_id: GO:1990290
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "pentose breakdown to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "pentose catabolic process to 1-butanol" EXACT [GOC:tt]
synonym: "pentose catabolic process to butanol" EXACT [GOC:tt]
synonym: "pentose catabolism to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "pentose degradation to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_obsolete: true

[Term]
id: GO:1902701
name: obsolete pentose catabolic process to propan-2-ol
namespace: biological_process
alt_id: GO:1990291
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of pentose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: The reason for obsoletion is that there is no evidence that this process exists.
synonym: "pentose breakdown to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "pentose catabolic process to isopropanol" EXACT [GOC:tt]
synonym: "pentose catabolic process to isopropyl alcohol" EXACT [GOC:tt]
synonym: "pentose catabolism to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "pentose degradation to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_obsolete: true

[Term]
id: GO:1902702
name: obsolete hexose catabolic process to propan-2-ol
namespace: biological_process
alt_id: GO:1990283
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: This term was obsoleted because there is no evidence that this pathway exists.
synonym: "hexose breakdown to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "hexose catabolic process to isopropanol" EXACT [GOC:tt]
synonym: "hexose catabolic process to isopropyl alcohol" EXACT [GOC:tt]
synonym: "hexose catabolism to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "hexose degradation to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" RELATED [GOC:tt]
is_obsolete: true

[Term]
id: GO:1902703
name: obsolete hexose catabolic process to butan-1-ol
namespace: biological_process
alt_id: GO:1990284
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: This term was obsoleted because there is no evidence that this pathway exists.
synonym: "hexose breakdown to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "hexose catabolic process to 1-butanol" EXACT [GOC:tt]
synonym: "hexose catabolic process to butanol" EXACT [GOC:tt]
synonym: "hexose catabolism to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "hexose degradation to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_obsolete: true

[Term]
id: GO:1902704
name: obsolete hexose catabolic process to acetone
namespace: biological_process
alt_id: GO:1990285
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to acetone." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: This term was obsoleted because there is no evidence that this pathway exists.
synonym: "hexose breakdown to acetone" EXACT [GOC:TermGenie]
synonym: "hexose catabolic process to 2-propanone" EXACT [GOC:tt]
synonym: "hexose catabolism to acetone" EXACT [GOC:TermGenie]
synonym: "hexose degradation to acetone" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_obsolete: true

[Term]
id: GO:1902705
name: obsolete hexose catabolic process to butyrate
namespace: biological_process
alt_id: GO:1990287
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: This term was obsoleted because there is no evidence that this pathway exists.
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "hexose breakdown to butyrate" EXACT [GOC:TermGenie]
synonym: "hexose catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "hexose degradation to butyrate" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902706
name: obsolete hexose catabolic process to acetate
namespace: biological_process
alt_id: GO:1990286
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: This term was obsoleted because there is no evidence that this pathway exists.
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "hexose breakdown to acetate" EXACT [GOC:TermGenie]
synonym: "hexose catabolism to acetate" EXACT [GOC:TermGenie]
synonym: "hexose degradation to acetate" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902707
name: obsolete hexose catabolic process to ethanol
namespace: biological_process
alt_id: GO:1990282
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hexose to ethanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
comment: This term was obsoleted because there is no evidence that this pathway exists.
synonym: "hexose breakdown to ethanol" EXACT [GOC:TermGenie]
synonym: "hexose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "hexose degradation to ethanol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_obsolete: true

[Term]
id: GO:1902708
name: response to plumbagin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1902709
name: cellular response to plumbagin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1902708 ! response to plumbagin

[Term]
id: GO:1902710
name: GABA receptor complex
namespace: cellular_component
def: "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
synonym: "gamma-aminobutyric acid receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:1902711
name: GABA-A receptor complex
namespace: cellular_component
def: "A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor)." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
comment: An example of this is GBRA1 in human (UniProt symbol P14867) in PMID:18790874.
is_a: GO:1902710 ! GABA receptor complex

[Term]
id: GO:1902712
name: G protein-coupled GABA receptor complex
namespace: cellular_component
def: "A protein complex which is capable of G protein-coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
comment: An example of this is GABR1 in human (UniProt symbol Q9UBS5) in PMID:18790874.
synonym: "G-protein coupled GABA receptor complex" EXACT []
is_a: GO:0038037 ! G protein-coupled receptor dimeric complex
is_a: GO:1902710 ! GABA receptor complex

[Term]
id: GO:1902716
name: cell cortex of growing cell tip
namespace: cellular_component
def: "Any cell cortex that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:24146635]
synonym: "cell cortex of growing cell end" EXACT []
is_a: GO:0051285 ! cell cortex of cell tip
relationship: part_of GO:0035838 ! growing cell tip

[Term]
id: GO:1902717
name: obsolete sequestering of iron ion
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of iron ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "sequestering of iron ion" EXACT []
is_obsolete: true

[Term]
id: GO:1902718
name: obsolete sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of copper ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "sequestering of copper ion" EXACT []
is_obsolete: true

[Term]
id: GO:1902719
name: obsolete extracellular sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "extracellular sequestering of copper ion" EXACT []
is_obsolete: true

[Term]
id: GO:1902720
name: obsolete intracellular sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "intracellular sequestering of copper ion" EXACT []
is_obsolete: true

[Term]
id: GO:1902721
name: negative regulation of prolactin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377]
synonym: "down regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of prolactin secretion" NARROW [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0070459 ! prolactin secretion

[Term]
id: GO:1902722
name: positive regulation of prolactin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377]
synonym: "activation of prolactin secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0070459 ! prolactin secretion

[Term]
id: GO:1902723
name: negative regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of satellite cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation
is_a: GO:0014859 ! negative regulation of skeletal muscle cell proliferation
relationship: negatively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation

[Term]
id: GO:1902724
name: positive regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of satellite cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of satellite cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation
is_a: GO:0014858 ! positive regulation of skeletal muscle cell proliferation
relationship: positively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation

[Term]
id: GO:1902725
name: negative regulation of satellite cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of satellite cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation
relationship: negatively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation

[Term]
id: GO:1902726
name: positive regulation of skeletal muscle satellite cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of satellite cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of satellite cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation
relationship: positively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation

[Term]
id: GO:1902727
name: negative regulation of growth factor dependent skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
is_a: GO:1902723 ! negative regulation of skeletal muscle satellite cell proliferation

[Term]
id: GO:1902728
name: positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
is_a: GO:1902724 ! positive regulation of skeletal muscle satellite cell proliferation

[Term]
id: GO:1902729
name: negative regulation of proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of proteoglycan anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan formation" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
relationship: negatively_regulates GO:0030166 ! proteoglycan biosynthetic process

[Term]
id: GO:1902730
name: positive regulation of proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of proteoglycan anabolism" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan formation" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
relationship: positively_regulates GO:0030166 ! proteoglycan biosynthetic process

[Term]
id: GO:1902731
name: negative regulation of chondrocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of cartilage cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of chondrocyte cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of chondrocyte proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
relationship: negatively_regulates GO:0035988 ! chondrocyte proliferation

[Term]
id: GO:1902732
name: positive regulation of chondrocyte proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of cartilage cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of chondrocyte cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of chondrocyte proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
relationship: positively_regulates GO:0035988 ! chondrocyte proliferation

[Term]
id: GO:1902733
name: regulation of growth plate cartilage chondrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
is_a: GO:1902738 ! regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: regulates GO:0003418 ! growth plate cartilage chondrocyte differentiation

[Term]
id: GO:1902734
name: regulation of receptor-mediated virion attachment to host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]
synonym: "regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
is_a: GO:1903900 ! regulation of viral life cycle
relationship: regulates GO:0046813 ! receptor-mediated virion attachment to host cell

[Term]
id: GO:1902735
name: negative regulation of receptor-mediated virion attachment to host cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]
synonym: "down regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie]
synonym: "inhibition of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie]
synonym: "negative regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell
relationship: negatively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell

[Term]
id: GO:1902736
name: positive regulation of receptor-mediated virion attachment to host cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]
synonym: "activation of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie]
synonym: "activation of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell
is_a: GO:1903902 ! positive regulation of viral life cycle
relationship: positively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell

[Term]
id: GO:1902737
name: dendritic filopodium
namespace: cellular_component
def: "A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines." [GO_REF:0000064, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24464040, Wikipedia:Dendritic_filopodia]
comment: Dendritic filopodia are generally less-well studied than dendritic spines because their transient nature makes them difficult to detect with traditional microscopy techniques, and because they are sometimes destroyed by sample preparation. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473.
synonym: "dendrite filopodium" EXACT []
is_a: GO:0030175 ! filopodium
is_a: GO:0043005 ! neuron projection
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:1902738
name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:1903010 ! regulation of bone development
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis

[Term]
id: GO:1902742
name: apoptotic process involved in development
namespace: biological_process
def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic process involved in anatomical structure development" EXACT []
synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:1902743
name: regulation of lamellipodium organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
relationship: regulates GO:0097581 ! lamellipodium organization

[Term]
id: GO:1902744
name: negative regulation of lamellipodium organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]
synonym: "down regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "downregulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "inhibition of lamellipodium organization" NARROW [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1902743 ! regulation of lamellipodium organization
relationship: negatively_regulates GO:0097581 ! lamellipodium organization

[Term]
id: GO:1902745
name: positive regulation of lamellipodium organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]
synonym: "activation of lamellipodium organization" NARROW [GOC:TermGenie]
synonym: "up regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "upregulation of lamellipodium organization" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:1902743 ! regulation of lamellipodium organization
relationship: positively_regulates GO:0097581 ! lamellipodium organization

[Term]
id: GO:1902746
name: regulation of lens fiber cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]
synonym: "regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:1902747
name: negative regulation of lens fiber cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]
synonym: "down regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lens fiber cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of lens fibre cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902746 ! regulation of lens fiber cell differentiation
relationship: negatively_regulates GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:1902748
name: positive regulation of lens fiber cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]
synonym: "activation of lens fiber cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of lens fibre cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902746 ! regulation of lens fiber cell differentiation
relationship: positively_regulates GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:1902749
name: regulation of cell cycle G2/M phase transition
namespace: biological_process
def: "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]
is_a: GO:1901987 ! regulation of cell cycle phase transition
relationship: regulates GO:0044839 ! cell cycle G2/M phase transition

[Term]
id: GO:1902750
name: negative regulation of cell cycle G2/M phase transition
namespace: biological_process
def: "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]
synonym: "down regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle G2/M phase transition" NARROW [GOC:TermGenie]
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition
relationship: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition

[Term]
id: GO:1902751
name: positive regulation of cell cycle G2/M phase transition
namespace: biological_process
def: "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]
synonym: "activation of cell cycle G2/M phase transition" NARROW [GOC:TermGenie]
synonym: "up regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition
relationship: positively_regulates GO:0044839 ! cell cycle G2/M phase transition

[Term]
id: GO:1902752
name: regulation of renal amino acid absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:1990297 ! renal amino acid absorption

[Term]
id: GO:1902753
name: negative regulation of renal amino acid absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]
synonym: "down regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "down-regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "downregulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "inhibition of renal amino acid absorption" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902752 ! regulation of renal amino acid absorption
relationship: negatively_regulates GO:1990297 ! renal amino acid absorption

[Term]
id: GO:1902754
name: positive regulation of renal amino acid absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]
synonym: "activation of renal amino acid absorption" NARROW [GOC:TermGenie]
synonym: "up regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "up-regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "upregulation of renal amino acid absorption" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902752 ! regulation of renal amino acid absorption
relationship: positively_regulates GO:1990297 ! renal amino acid absorption

[Term]
id: GO:1902755
name: sulfurated eukaryotic molybdenum cofactor(2-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:1902756
name: sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) anabolism" EXACT [GOC:TermGenie]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) formation" EXACT [GOC:TermGenie]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-5963
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1902755 ! sulfurated eukaryotic molybdenum cofactor(2-) metabolic process

[Term]
id: GO:1902757
name: bis(molybdopterin guanine dinucleotide)molybdenum metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process

[Term]
id: GO:1902758
name: bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process
namespace: biological_process
alt_id: GO:0061600
def: "The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum anabolism" EXACT [GOC:TermGenie]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum biosynthesis" EXACT [GOC:TermGenie]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum formation" EXACT [GOC:TermGenie]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum synthesis" EXACT [GOC:TermGenie]
synonym: "bis-Mo-molybdopterin-guanine dinucleotide cofactor biosynthetic process" EXACT []
xref: MetaCyc:PWY-5964
is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process
is_a: GO:1902757 ! bis(molybdopterin guanine dinucleotide)molybdenum metabolic process

[Term]
id: GO:1902759
name: Mo(VI)-molybdopterin cytosine dinucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process

[Term]
id: GO:1902760
name: Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process
namespace: biological_process
alt_id: GO:0061601
def: "The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide formation" EXACT [GOC:TermGenie]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process" EXACT []
xref: MetaCyc:PWY-6476
is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:1902759 ! Mo(VI)-molybdopterin cytosine dinucleotide metabolic process

[Term]
id: GO:1902761
name: positive regulation of chondrocyte development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie]
synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0032332 ! positive regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
relationship: positively_regulates GO:0002063 ! chondrocyte development

[Term]
id: GO:1902762
name: regulation of embryonic skeletal joint development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0072498 ! embryonic skeletal joint development

[Term]
id: GO:1902763
name: negative regulation of embryonic skeletal joint development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "down regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "inhibition of embryonic skeletal joint development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902762 ! regulation of embryonic skeletal joint development
relationship: negatively_regulates GO:0072498 ! embryonic skeletal joint development

[Term]
id: GO:1902764
name: positive regulation of embryonic skeletal joint development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "activation of embryonic skeletal joint development" NARROW [GOC:TermGenie]
synonym: "up regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902762 ! regulation of embryonic skeletal joint development
relationship: positively_regulates GO:0072498 ! embryonic skeletal joint development

[Term]
id: GO:1902766
name: skeletal muscle satellite cell migration
namespace: biological_process
def: "The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells." [GO_REF:0000091, GOC:mr, GOC:TermGenie, PMID:17996437, PMID:19609936]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:1902767
name: isoprenoid biosynthetic process via mevalonate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoprenoid via mevalonate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:11078528]
synonym: "isoprenoid anabolism via mevalonate" EXACT [GOC:TermGenie]
synonym: "isoprenoid biosynthesis via mevalonate" EXACT [GOC:TermGenie]
synonym: "isoprenoid formation via mevalonate" EXACT [GOC:TermGenie]
synonym: "isoprenoid synthesis via mevalonate" EXACT [GOC:TermGenie]
is_a: GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:1902768
name: isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoprenoid via 1-deoxy-D-xylulose 5-phosphate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:23746261]
synonym: "isoprenoid anabolism via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
synonym: "isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
synonym: "isoprenoid formation via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
synonym: "isoprenoid synthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:1902769
name: regulation of choline O-acetyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]
subset: gocheck_obsoletion_candidate
synonym: "regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1902770
name: obsolete negative regulation of choline O-acetyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CHOACTase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of choline acetylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of choline acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902771
name: obsolete positive regulation of choline O-acetyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CHOACTase activity" NARROW [GOC:TermGenie]
synonym: "activation of choline acetylase activity" NARROW [GOC:TermGenie]
synonym: "activation of choline acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902772
name: obsolete positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signaling pathway
namespace: biological_process
def: "OBSOLETE. Any positive regulation of phosphorelay signal transduction system that is involved in hydrogen peroxide mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:18406331]
comment: This term was obsoleted because it represents a pre-composed term that should be captured as a GO-CAM model.
synonym: "activation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphorelay signal transduction system involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0034599

[Term]
id: GO:1902773
name: GTPase activator complex
namespace: cellular_component
def: "A protein complex which is capable of GTPase activator activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16449187]
comment: An example of this is BFA1 in Saccharomyces cerevisiae (P47113) in PMID:16449187 (inferred from direct assay).
is_a: GO:0150005 ! enzyme activator complex

[Term]
id: GO:1902774
name: late endosome to lysosome transport
namespace: biological_process
def: "The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442]
comment: an example of this is snapin in mouse (Q9Z266) in PMID:20920792 inferred from mutant phenotype
synonym: "prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie]
is_a: GO:0007041 ! lysosomal transport

[Term]
id: GO:1902775
name: mitochondrial large ribosomal subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit." [GO_REF:0000079, GOC:TermGenie, PMID:24206665]
synonym: "39S ribosomal subunit, mitochondrial assembly" NARROW [GOC:TermGenie]
synonym: "39S ribosomal subunit, mitochondrial formation" NARROW [GOC:TermGenie]
synonym: "mitochondrial large ribosomal subunit formation" EXACT [GOC:TermGenie]
is_a: GO:0000027 ! ribosomal large subunit assembly
relationship: part_of GO:0061668 ! mitochondrial ribosome assembly

[Term]
id: GO:1902776
name: 6-sulfoquinovose(1-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506]
synonym: "6-sulfoquinovose(1-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:1902777
name: 6-sulfoquinovose(1-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506]
synonym: "6-sulfoquinovose(1-) breakdown" EXACT [GOC:TermGenie]
synonym: "6-sulfoquinovose(1-) catabolism" EXACT [GOC:TermGenie]
synonym: "6-sulfoquinovose(1-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1902776 ! 6-sulfoquinovose(1-) metabolic process

[Term]
id: GO:1902778
name: response to alkane
namespace: biological_process
alt_id: GO:1990373
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995]
synonym: "process resulting in tolerance to alkane" NARROW []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1902779
name: cellular response to alkane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902778 ! response to alkane

[Term]
id: GO:1902780
name: response to nonane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739]
is_a: GO:1902778 ! response to alkane

[Term]
id: GO:1902781
name: cellular response to nonane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902780 ! response to nonane

[Term]
id: GO:1902782
name: response to decane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902778 ! response to alkane

[Term]
id: GO:1902783
name: cellular response to decane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902782 ! response to decane

[Term]
id: GO:1902784
name: response to undecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902778 ! response to alkane

[Term]
id: GO:1902785
name: cellular response to undecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902784 ! response to undecane

[Term]
id: GO:1902786
name: response to dodecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902778 ! response to alkane

[Term]
id: GO:1902787
name: cellular response to dodecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902786 ! response to dodecane

[Term]
id: GO:1902788
name: response to isooctane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]
is_a: GO:1902778 ! response to alkane

[Term]
id: GO:1902789
name: cellular response to isooctane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902788 ! response to isooctane

[Term]
id: GO:1902790
name: undecan-2-one metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559]
synonym: "undecan-2-one metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:1902791
name: undecan-2-one biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559]
synonym: "undecan-2-one anabolism" EXACT [GOC:TermGenie]
synonym: "undecan-2-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "undecan-2-one formation" EXACT [GOC:TermGenie]
synonym: "undecan-2-one synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1902790 ! undecan-2-one metabolic process

[Term]
id: GO:1902792
name: pyrroline-5-carboxylate reductase complex
namespace: cellular_component
def: "A protein complex which is capable of pyrroline-5-carboxylate reductase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:2722838]
comment: An example of this is PYCR1 in human (P32322) in PMID:2722838 (inferred from direct assay).
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1902793
name: glutamate decarboxylase complex
namespace: cellular_component
def: "A protein complex which is capable of glutamate decarboxylase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17384644]
comment: An example of this is GAD1 in human (Q99259) in PMID:17384644 (inferred from direct assay).
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1902794
name: siRNA-independent facultative heterochromatin formation
namespace: biological_process
def: "The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process independent of small interfering RNAs." [PMID:22144463, PMID:24210919]
synonym: "heterochromatin island assembly" EXACT []
synonym: "heterochromatin island formation" EXACT [GOC:TermGenie]
synonym: "siRNA-independent facultative heterochromatin assembly" EXACT []
is_a: GO:0140718 ! facultative heterochromatin formation

[Term]
id: GO:1902795
name: siRNA-mediated facultative heterochromatin formation
namespace: biological_process
def: "The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a small interfering RNA." [GO_REF:0000079, GOC:TermGenie, PMID:23151475, PMID:24210919]
synonym: "heterochromatin domain assembly" EXACT []
synonym: "heterochromatin domain formation" EXACT [GOC:TermGenie]
synonym: "HOOD assembly" EXACT [GOC:TermGenie]
synonym: "HOOD formation" EXACT [GOC:TermGenie]
synonym: "siRNA-dependent facultative heterochromatin assembly" EXACT []
synonym: "siRNA-dependent facultative heterochromatin formation" EXACT []
is_a: GO:0140718 ! facultative heterochromatin formation
is_a: GO:0141194 ! siRNA-mediated heterochromatin formation

[Term]
id: GO:1902796
name: regulation of snoRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903323 ! regulation of snoRNA metabolic process
relationship: regulates GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:1902797
name: negative regulation of snoRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "down regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "down-regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "downregulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "inhibition of snoRNA processing" NARROW [GOC:TermGenie]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:1902796 ! regulation of snoRNA processing
is_a: GO:1903324 ! negative regulation of snoRNA metabolic process
relationship: negatively_regulates GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:1902798
name: positive regulation of snoRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "activation of snoRNA processing" NARROW [GOC:TermGenie]
synonym: "up regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "up-regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "upregulation of snoRNA processing" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:1902796 ! regulation of snoRNA processing
is_a: GO:1903325 ! positive regulation of snoRNA metabolic process
relationship: positively_regulates GO:0043144 ! sno(s)RNA processing

[Term]
id: GO:1902799
name: regulation of phosphodiesterase I activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphodiesterase activity" BROAD [GOC:TermGenie]
is_a: GO:1905777 ! regulation of exonuclease activity

[Term]
id: GO:1902800
name: positive regulation of phosphodiesterase I activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510]
subset: gocheck_obsoletion_candidate
synonym: "activation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" NARROW [GOC:TermGenie]
synonym: "activation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "activation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "activation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "activation of nucleotide pyrophosphatase/phosphodiesterase I activity" NARROW [GOC:TermGenie]
synonym: "activation of oligonucleate 5'-nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of orthophosphoric diester phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of PDE I activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphodiesterase I activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "up regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "up regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "upregulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "upregulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphodiesterase I activity" EXACT [GOC:TermGenie]
is_a: GO:1902799 ! regulation of phosphodiesterase I activity
is_a: GO:1905779 ! positive regulation of exonuclease activity

[Term]
id: GO:1902801
name: regulation of siRNA-independent facultative heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of siRNA-independent facultative heterochromatin assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "regulation of heterochromatin island assembly" EXACT []
synonym: "regulation of heterochromatin island formation" EXACT [GOC:TermGenie]
synonym: "regulation of siRNA-independent facultative heterochromatin assembly" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin formation
relationship: regulates GO:1902794 ! siRNA-independent facultative heterochromatin formation

[Term]
id: GO:1902802
name: regulation of siRNA-mediated facultative heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of siRNA-dependent facultative heterochromatin formation." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "regulation of heterochromatin domain assembly" EXACT []
synonym: "regulation of heterochromatin domain formation" EXACT [GOC:TermGenie]
synonym: "regulation of HOOD assembly" EXACT [GOC:TermGenie]
synonym: "regulation of HOOD formation" EXACT [GOC:TermGenie]
synonym: "regulation of siRNA-dependent facultative heterochromatin assembly" EXACT []
synonym: "regulation of siRNA-dependent facultative heterochromatin formation" EXACT []
is_a: GO:0010964 ! regulation of regulatory ncRNA-mediated heterochromatin formation
relationship: regulates GO:1902795 ! siRNA-mediated facultative heterochromatin formation

[Term]
id: GO:1902803
name: regulation of synaptic vesicle transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]
synonym: "regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:1902804
name: negative regulation of synaptic vesicle transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]
synonym: "down regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1902803 ! regulation of synaptic vesicle transport
relationship: negatively_regulates GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:1902805
name: positive regulation of synaptic vesicle transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]
synonym: "activation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "activation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "activation of synaptic vesicle transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1902803 ! regulation of synaptic vesicle transport
relationship: positively_regulates GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:1902806
name: regulation of cell cycle G1/S phase transition
namespace: biological_process
def: "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:1901987 ! regulation of cell cycle phase transition
relationship: regulates GO:0044843 ! cell cycle G1/S phase transition

[Term]
id: GO:1902807
name: negative regulation of cell cycle G1/S phase transition
namespace: biological_process
def: "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle G1/S phase transition" NARROW [GOC:TermGenie]
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition
relationship: negatively_regulates GO:0044843 ! cell cycle G1/S phase transition

[Term]
id: GO:1902808
name: positive regulation of cell cycle G1/S phase transition
namespace: biological_process
def: "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of cell cycle G1/S phase transition" NARROW [GOC:TermGenie]
synonym: "up regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition
relationship: positively_regulates GO:0044843 ! cell cycle G1/S phase transition

[Term]
id: GO:1902809
name: regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
relationship: regulates GO:0098528 ! skeletal muscle fiber differentiation

[Term]
id: GO:1902810
name: negative regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
is_a: GO:0010832 ! negative regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation
relationship: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation

[Term]
id: GO:1902811
name: positive regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
is_a: GO:0010831 ! positive regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation
relationship: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation

[Term]
id: GO:1902812
name: obsolete regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0003140
consider: GO:0030510

[Term]
id: GO:1902813
name: obsolete negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "down regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "inhibition of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "inhibition of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie]
synonym: "inhibition of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "negative regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "negative regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0003140
consider: GO:0030514

[Term]
id: GO:1902814
name: obsolete positive regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "activation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie]
synonym: "activation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "positive regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "positive regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0003140
consider: GO:0030513

[Term]
id: GO:1902815
name: N,N'-diacetylchitobiose import
namespace: biological_process
def: "The directed movement of N,N'-diacetylchitobiose into a cell or organelle." [GO_REF:0000073, GOC:am, GOC:TermGenie, PMID:9405618]
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:1902816
name: regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0035372 ! protein localization to microtubule

[Term]
id: GO:1902817
name: negative regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:1902816 ! regulation of protein localization to microtubule
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:0035372 ! protein localization to microtubule

[Term]
id: GO:1902818
name: ethyl acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "ethyl acetate metabolism" EXACT [GOC:TermGenie]
synonym: "ethyl ethanoate metabolic process" EXACT []
is_a: GO:1900619 ! acetate ester metabolic process

[Term]
id: GO:1902819
name: ethyl acetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "ethyl acetate anabolism" EXACT [GOC:TermGenie]
synonym: "ethyl acetate biosynthesis" EXACT [GOC:TermGenie]
synonym: "ethyl acetate formation" EXACT [GOC:TermGenie]
synonym: "ethyl acetate synthesis" EXACT [GOC:TermGenie]
synonym: "ethyl ethanoate biosynthetic process" EXACT []
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1902818 ! ethyl acetate metabolic process

[Term]
id: GO:1902820
name: 1-undecene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "1-undecene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! alkene metabolic process

[Term]
id: GO:1902821
name: 1-undecene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "1-undecene anabolism" EXACT [GOC:TermGenie]
synonym: "1-undecene biosynthesis" EXACT [GOC:TermGenie]
synonym: "1-undecene formation" EXACT [GOC:TermGenie]
synonym: "1-undecene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1902820 ! 1-undecene metabolic process

[Term]
id: GO:1902822
name: regulation of late endosome to lysosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]
synonym: "regulation of prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie]
is_a: GO:1903335 ! regulation of vacuolar transport
relationship: regulates GO:1902774 ! late endosome to lysosome transport

[Term]
id: GO:1902823
name: negative regulation of late endosome to lysosome transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]
synonym: "down regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "downregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "inhibition of late endosome to lysosome transport" NARROW [GOC:TermGenie]
is_a: GO:1902822 ! regulation of late endosome to lysosome transport
is_a: GO:1903336 ! negative regulation of vacuolar transport
relationship: negatively_regulates GO:1902774 ! late endosome to lysosome transport

[Term]
id: GO:1902824
name: positive regulation of late endosome to lysosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]
synonym: "activation of late endosome to lysosome transport" NARROW [GOC:TermGenie]
synonym: "up regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "upregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
is_a: GO:1902822 ! regulation of late endosome to lysosome transport
is_a: GO:1903337 ! positive regulation of vacuolar transport
relationship: positively_regulates GO:1902774 ! late endosome to lysosome transport

[Term]
id: GO:1902829
name: regulation of spinal cord association neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0021527 ! spinal cord association neuron differentiation

[Term]
id: GO:1902830
name: negative regulation of spinal cord association neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "down regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of spinal cord association neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation
relationship: negatively_regulates GO:0021527 ! spinal cord association neuron differentiation

[Term]
id: GO:1902831
name: positive regulation of spinal cord association neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "activation of spinal cord association neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation
relationship: positively_regulates GO:0021527 ! spinal cord association neuron differentiation

[Term]
id: GO:1902832
name: negative regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "down regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "inhibition of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie]
is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
relationship: negatively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord

[Term]
id: GO:1902833
name: positive regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "activation of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
relationship: positively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord

[Term]
id: GO:1902834
name: regulation of proline import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
synonym: "regulation of proline import into cell" EXACT []
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:1905647 ! proline import across plasma membrane

[Term]
id: GO:1902835
name: negative regulation of proline import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
synonym: "down regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of proline import into cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of proline import into cell" EXACT []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1902834 ! regulation of proline import across plasma membrane
relationship: negatively_regulates GO:1905647 ! proline import across plasma membrane

[Term]
id: GO:1902836
name: positive regulation of proline import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
synonym: "activation of proline import into cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of proline import into cell" EXACT []
synonym: "up regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of proline import into cell" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1902834 ! regulation of proline import across plasma membrane
relationship: positively_regulates GO:1905647 ! proline import across plasma membrane

[Term]
id: GO:1902838
name: regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie]
synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie]
synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
relationship: regulates GO:0030473 ! nuclear migration along microtubule

[Term]
id: GO:1902839
name: negative regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
relationship: negatively_regulates GO:0030473 ! nuclear migration along microtubule

[Term]
id: GO:1902840
name: positive regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
relationship: positively_regulates GO:0030473 ! nuclear migration along microtubule

[Term]
id: GO:1902841
name: regulation of netrin-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24004945]
synonym: "regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0038007 ! netrin-activated signaling pathway

[Term]
id: GO:1902842
name: negative regulation of netrin-activated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24004945]
synonym: "down regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of netrin signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-activated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-activated signalling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902841 ! regulation of netrin-activated signaling pathway
relationship: negatively_regulates GO:0038007 ! netrin-activated signaling pathway

[Term]
id: GO:1902843
name: positive regulation of netrin-activated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24004945]
synonym: "activation of netrin signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-activated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-activated signalling pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902841 ! regulation of netrin-activated signaling pathway
relationship: positively_regulates GO:0038007 ! netrin-activated signaling pathway

[Term]
id: GO:1902844
name: obsolete positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. A negative regulation of canonical Wnt signaling pathway that results in positive regulation of spinal cord association neuron differentiation." [GO_REF:0000063, GOC:mr, GOC:TermGenie, PMID:11262869]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0090090
consider: GO:1902831

[Term]
id: GO:1902845
name: negative regulation of mitotic spindle elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic spindle elongation" NARROW [GOC:TermGenie]
synonym: "inhibition of spindle elongation during mitosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0032888 ! regulation of mitotic spindle elongation
relationship: negatively_regulates GO:0000022 ! mitotic spindle elongation

[Term]
id: GO:1902846
name: positive regulation of mitotic spindle elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of mitotic spindle elongation" NARROW [GOC:TermGenie]
synonym: "activation of spindle elongation during mitosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0032888 ! regulation of mitotic spindle elongation
is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation
relationship: positively_regulates GO:0000022 ! mitotic spindle elongation

[Term]
id: GO:1902847
name: regulation of neuronal signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0023041 ! neuronal signal transduction

[Term]
id: GO:1902848
name: negative regulation of neuronal signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie]
synonym: "down regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "inhibition of neuronal signal transduction" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902847 ! regulation of neuronal signal transduction
relationship: negatively_regulates GO:0023041 ! neuronal signal transduction

[Term]
id: GO:1902849
name: positive regulation of neuronal signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie]
synonym: "activation of neuronal signal transduction" NARROW [GOC:TermGenie]
synonym: "up regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902847 ! regulation of neuronal signal transduction
relationship: positively_regulates GO:0023041 ! neuronal signal transduction

[Term]
id: GO:1902850
name: microtubule cytoskeleton organization involved in mitosis
namespace: biological_process
def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626]
synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie]
synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:1902852
name: regulation of nuclear migration during mitotic telophase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
relationship: regulates GO:0090561 ! nuclear migration during mitotic telophase

[Term]
id: GO:1902853
name: negative regulation of nuclear migration during mitotic telophase
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "inhibition of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie]
is_a: GO:1902839 ! negative regulation of nuclear migration along microtubule
is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase
relationship: negatively_regulates GO:0090561 ! nuclear migration during mitotic telophase

[Term]
id: GO:1902854
name: positive regulation of nuclear migration during mitotic telophase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie]
synonym: "up regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
is_a: GO:1902840 ! positive regulation of nuclear migration along microtubule
is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase
relationship: positively_regulates GO:0090561 ! nuclear migration during mitotic telophase

[Term]
id: GO:1902855
name: regulation of non-motile cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]
synonym: "regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "regulation of nonmotile primary cilium assembly" RELATED []
synonym: "regulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:1902017 ! regulation of cilium assembly
relationship: regulates GO:1905515 ! non-motile cilium assembly

[Term]
id: GO:1902856
name: negative regulation of non-motile cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]
synonym: "down regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of immotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of nonmotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of nonmotile primary cilium assembly" RELATED []
synonym: "negative regulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:1902018 ! negative regulation of cilium assembly
is_a: GO:1902855 ! regulation of non-motile cilium assembly
relationship: negatively_regulates GO:1905515 ! non-motile cilium assembly

[Term]
id: GO:1902857
name: positive regulation of non-motile cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]
synonym: "activation of immotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "activation of nonmotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of sensory cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of nonmotile primary cilium assembly" RELATED []
synonym: "positive regulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of sensory cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0045724 ! positive regulation of cilium assembly
is_a: GO:1902855 ! regulation of non-motile cilium assembly
relationship: positively_regulates GO:1905515 ! non-motile cilium assembly

[Term]
id: GO:1902858
name: propionyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]
synonym: "propionyl-CoA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:1902859
name: propionyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]
synonym: "propionyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902858 ! propionyl-CoA metabolic process

[Term]
id: GO:1902860
name: propionyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]
synonym: "propionyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902858 ! propionyl-CoA metabolic process

[Term]
id: GO:1902862
name: obsolete glycerol catabolic process to glycerone phosphate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycerol to glycerone phosphate." [GO_REF:0000093, GOC:dph, GOC:TermGenie, ISBN:0201090910]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "glycerol breakdown to glycerone phosphate" EXACT [GOC:TermGenie]
synonym: "glycerol catabolic process to glycerone phosphate" EXACT []
synonym: "glycerol catabolism to glycerone phosphate" EXACT [GOC:TermGenie]
synonym: "glycerol degradation to glycerone phosphate" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902863
name: regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0031076 ! embryonic camera-type eye development

[Term]
id: GO:1902864
name: negative regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
relationship: negatively_regulates GO:0031076 ! embryonic camera-type eye development

[Term]
id: GO:1902865
name: positive regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
relationship: positively_regulates GO:0031076 ! embryonic camera-type eye development

[Term]
id: GO:1902866
name: regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:1902867
name: negative regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retinal development" RELATED [GOC:TermGenie]
synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retinal development" RELATED [GOC:TermGenie]
synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
relationship: negatively_regulates GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:1902868
name: positive regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "activation of retinal development" RELATED [GOC:TermGenie]
synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
relationship: positively_regulates GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:1902869
name: regulation of amacrine cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0035881 ! amacrine cell differentiation

[Term]
id: GO:1902870
name: negative regulation of amacrine cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of amacrine cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of amacrine neuron differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1902869 ! regulation of amacrine cell differentiation
relationship: negatively_regulates GO:0035881 ! amacrine cell differentiation

[Term]
id: GO:1902871
name: positive regulation of amacrine cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of amacrine cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of amacrine neuron differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1902869 ! regulation of amacrine cell differentiation
relationship: positively_regulates GO:0035881 ! amacrine cell differentiation

[Term]
id: GO:1902872
name: regulation of horizontal cell localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0035852 ! horizontal cell localization

[Term]
id: GO:1902873
name: negative regulation of horizontal cell localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "down regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "down regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "downregulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "downregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "inhibition of horizontal cell localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of horizontal cell localization" NARROW [GOC:TermGenie]
synonym: "inhibition of horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie]
synonym: "inhibition of retinal horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "negative regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1902872 ! regulation of horizontal cell localization
relationship: negatively_regulates GO:0035852 ! horizontal cell localization

[Term]
id: GO:1902874
name: positive regulation of horizontal cell localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of horizontal cell localisation" NARROW [GOC:TermGenie]
synonym: "activation of horizontal cell localization" NARROW [GOC:TermGenie]
synonym: "activation of horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "activation of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie]
synonym: "activation of retinal horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "positive regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "up regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "upregulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1902872 ! regulation of horizontal cell localization
relationship: positively_regulates GO:0035852 ! horizontal cell localization

[Term]
id: GO:1902875
name: regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie]
synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie]
synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009880 ! embryonic pattern specification

[Term]
id: GO:1902876
name: negative regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902875 ! regulation of embryonic pattern specification
relationship: negatively_regulates GO:0009880 ! embryonic pattern specification

[Term]
id: GO:1902877
name: positive regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902875 ! regulation of embryonic pattern specification
relationship: positively_regulates GO:0009880 ! embryonic pattern specification

[Term]
id: GO:1902878
name: obsolete regulation of BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902879
name: obsolete negative regulation of BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "down regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "inhibition of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "inhibition of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "inhibition of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "inhibition of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "negative regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "negative regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "negative regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902880
name: obsolete positive regulation of BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activation of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "activation of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "activation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "activation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "positive regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902882
name: regulation of response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0006979 ! response to oxidative stress

[Term]
id: GO:1902883
name: negative regulation of response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
synonym: "down regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1902882 ! regulation of response to oxidative stress
relationship: negatively_regulates GO:0006979 ! response to oxidative stress

[Term]
id: GO:1902884
name: positive regulation of response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
synonym: "activation of response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1902882 ! regulation of response to oxidative stress
relationship: positively_regulates GO:0006979 ! response to oxidative stress

[Term]
id: GO:1902885
name: obsolete regulation of proteasome-activating ATPase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902886
name: obsolete negative regulation of proteasome-activating ATPase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "down regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "down regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "downregulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "downregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasomal ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome-activating ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902887
name: obsolete positive regulation of proteasome-activating ATPase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of proteasomal ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "activation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "activation of proteasome-activating ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "up regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "up regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "upregulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "upregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902888
name: protein localization to astral microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an astral microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030]
synonym: "protein localisation in astral microtubule" EXACT [GOC:TermGenie]
synonym: "protein localisation to astral microtubule" EXACT [GOC:TermGenie]
synonym: "protein localization in astral microtubule" EXACT [GOC:TermGenie]
is_a: GO:1902889 ! protein localization to spindle microtubule
is_a: GO:1905755 ! protein localization to cytoplasmic microtubule

[Term]
id: GO:1902889
name: protein localization to spindle microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a spindle microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030]
synonym: "protein localisation in spindle microtubule" EXACT [GOC:TermGenie]
synonym: "protein localisation to spindle microtubule" EXACT [GOC:TermGenie]
synonym: "protein localization in spindle microtubule" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule

[Term]
id: GO:1902890
name: regulation of root hair elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0048767 ! root hair elongation

[Term]
id: GO:1902891
name: negative regulation of root hair elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]
synonym: "down regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of root hair elongation" NARROW [GOC:TermGenie]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1902890 ! regulation of root hair elongation
is_a: GO:1903430 ! negative regulation of cell maturation
relationship: negatively_regulates GO:0048767 ! root hair elongation

[Term]
id: GO:1902892
name: positive regulation of root hair elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]
synonym: "activation of root hair elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of root hair elongation" EXACT [GOC:TermGenie]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1902890 ! regulation of root hair elongation
is_a: GO:1903431 ! positive regulation of cell maturation
relationship: positively_regulates GO:0048767 ! root hair elongation

[Term]
id: GO:1902893
name: regulation of miRNA transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
synonym: "regulation of microRNA gene transcription" EXACT []
synonym: "regulation of miRNA gene transcription" EXACT []
synonym: "regulation of pri-miRNA transcription by RNA polymerase II" EXACT []
synonym: "regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT []
synonym: "regulation of primary miRNA gene transcription" EXACT []
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:2000628 ! regulation of miRNA metabolic process
relationship: regulates GO:0061614 ! miRNA transcription

[Term]
id: GO:1902894
name: negative regulation of miRNA transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
synonym: "down regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of microRNA gene transcription" EXACT []
synonym: "negative regulation of miRNA gene transcription" EXACT []
synonym: "negative regulation of pri-miRNA transcription by RNA polymerase II" EXACT []
synonym: "negative regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT []
synonym: "negative regulation of primary miRNA gene transcription" EXACT []
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
is_a: GO:1902893 ! regulation of miRNA transcription
is_a: GO:2000629 ! negative regulation of miRNA metabolic process
relationship: negatively_regulates GO:0061614 ! miRNA transcription

[Term]
id: GO:1902895
name: positive regulation of miRNA transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
synonym: "activation of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of microRNA gene transcription" EXACT []
synonym: "positive regulation of pri-miRNA gene transcription" EXACT []
synonym: "positive regulation of pri-miRNA transcription by RNA polymerase II" EXACT []
synonym: "positive regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT []
synonym: "positive regulation of primary miRNA gene transcription" EXACT []
synonym: "up regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:1902893 ! regulation of miRNA transcription
is_a: GO:2000630 ! positive regulation of miRNA metabolic process
relationship: positively_regulates GO:0061614 ! miRNA transcription

[Term]
id: GO:1902896
name: terminal web assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a terminal web." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21949650]
synonym: "terminal web formation" EXACT [GOC:TermGenie]
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:1902897
name: regulation of postsynaptic density protein 95 clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:10570482]
synonym: "regulation of Dlg4 clustering" EXACT [GOC:TermGenie]
synonym: "regulation of post-synaptic density protein 95 clustering" EXACT [GOC:TermGenie]
synonym: "regulation of PSD-95 clustering" EXACT [GOC:TermGenie]
is_a: GO:1905475 ! regulation of protein localization to membrane
is_a: GO:1905874 ! regulation of postsynaptic density organization
relationship: regulates GO:0097119 ! postsynaptic density protein 95 clustering

[Term]
id: GO:1902898
name: fatty acid methyl ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218]
synonym: "FAME metabolic process" EXACT []
synonym: "fatty acid methyl ester metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:1902899
name: fatty acid methyl ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218]
synonym: "FAME biosynthetic process" EXACT []
synonym: "fatty acid methyl ester anabolism" EXACT [GOC:TermGenie]
synonym: "fatty acid methyl ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "fatty acid methyl ester formation" EXACT [GOC:TermGenie]
synonym: "fatty acid methyl ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
is_a: GO:1902898 ! fatty acid methyl ester metabolic process

[Term]
id: GO:1902900
name: gut granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a gut granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:17202409]
synonym: "gut granule biogenesis" EXACT [PMID:17202409]
synonym: "gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:1902901
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in stress response to cadmium ion." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:17888400]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0045944
consider: GO:1990170

[Term]
id: GO:1902902
name: negative regulation of autophagosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly." [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012]
synonym: "down regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "down regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "down regulation of PAS formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of PAS formation" NARROW [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "downregulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "downregulation of PAS formation" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "inhibition of autophagosome biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagosome formation" NARROW [GOC:TermGenie]
synonym: "inhibition of PAS formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "negative regulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of PAS formation" NARROW [GOC:TermGenie]
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:2000785 ! regulation of autophagosome assembly
relationship: negatively_regulates GO:0000045 ! autophagosome assembly

[Term]
id: GO:1902903
name: regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:1902904
name: negative regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:1902905
name: positive regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "activation of fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of fibril organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: positively_regulates GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:1902906
name: proteasome storage granule assembly
namespace: biological_process
alt_id: GO:1990237
def: "The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178]
synonym: "proteasome storage granule formation" EXACT [GOC:TermGenie]
synonym: "PSG assembly" RELATED [GOC:TermGenie]
synonym: "PSG formation" RELATED [GOC:TermGenie]
synonym: "sequestration of proteasome core complex in proteasome storage granule" NARROW []
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:1902907
name: proteasome storage granule disassembly
namespace: biological_process
def: "The disaggregation of a proteasome storage granule into its constituent components." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178]
synonym: "PSG disassembly" RELATED [GOC:TermGenie]
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:1902908
name: regulation of melanosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0032402 ! melanosome transport

[Term]
id: GO:1902909
name: negative regulation of melanosome transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]
synonym: "down regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "downregulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "inhibition of melanosome transport" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1902908 ! regulation of melanosome transport
relationship: negatively_regulates GO:0032402 ! melanosome transport

[Term]
id: GO:1902910
name: positive regulation of melanosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]
synonym: "activation of melanosome transport" NARROW [GOC:TermGenie]
synonym: "up regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "upregulation of melanosome transport" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1902908 ! regulation of melanosome transport
relationship: positively_regulates GO:0032402 ! melanosome transport

[Term]
id: GO:1902911
name: protein kinase complex
namespace: cellular_component
def: "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]
comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay).
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:1902912
name: pyruvate kinase complex
namespace: cellular_component
def: "A protein complex which is capable of pyruvate kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]
comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay).
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:1902913
name: positive regulation of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506]
synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
relationship: positively_regulates GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:1902914
name: regulation of protein polyubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]
synonym: "regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031396 ! regulation of protein ubiquitination
relationship: regulates GO:0000209 ! protein polyubiquitination

[Term]
id: GO:1902915
name: negative regulation of protein polyubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]
synonym: "down regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "down regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "downregulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "downregulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "inhibition of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "inhibition of protein polyubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polyubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polyubiquitylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:1902914 ! regulation of protein polyubiquitination
relationship: negatively_regulates GO:0000209 ! protein polyubiquitination

[Term]
id: GO:1902916
name: positive regulation of protein polyubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]
synonym: "activation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "activation of protein polyubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein polyubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein polyubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "up regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "upregulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:1902914 ! regulation of protein polyubiquitination
relationship: positively_regulates GO:0000209 ! protein polyubiquitination

[Term]
id: GO:1902917
name: positive regulation of mating projection assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mating projection assembly." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:12455985]
synonym: "activation of mating projection assembly" NARROW [GOC:TermGenie]
synonym: "activation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of mating projection assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of mating projection assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of mating projection assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of mating projection biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0031383 ! regulation of mating projection assembly
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
relationship: part_of GO:0031139 ! positive regulation of conjugation with cellular fusion
relationship: positively_regulates GO:0031382 ! mating projection formation

[Term]
id: GO:1902918
name: poly(5-hydroxyvalerate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(5-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process

[Term]
id: GO:1902919
name: poly(5-hydroxyvalerate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(5-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(5-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(5-hydroxyvalerate) formation" EXACT [GOC:TermGenie]
synonym: "poly(5-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902918 ! poly(5-hydroxyvalerate) metabolic process
is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process

[Term]
id: GO:1902920
name: poly(hydroxyvalerate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(hydroxyvalerate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process

[Term]
id: GO:1902921
name: poly(hydroxyvalerate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(hydroxyvalerate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyvalerate) formation" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyvalerate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process
is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process

[Term]
id: GO:1902922
name: poly(3-hydroxyvalerate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(3-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process

[Term]
id: GO:1902923
name: poly(3-hydroxyvalerate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(3-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(3-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(3-hydroxyvalerate) formation" EXACT [GOC:TermGenie]
synonym: "poly(3-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process
is_a: GO:1902922 ! poly(3-hydroxyvalerate) metabolic process

[Term]
id: GO:1902924
name: poly(hydroxyalkanoate) biosynthetic process from glucose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from glucose." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:24425304]
synonym: "poly(hydroxyalkanoate) anabolism from glucose" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) biosynthesis from glucose" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) formation from glucose" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) synthesis from glucose" EXACT [GOC:TermGenie]
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process

[Term]
id: GO:1902925
name: poly(hydroxyalkanoate) biosynthetic process from fatty acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from fatty acid." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:21129764]
synonym: "poly(hydroxyalkanoate) anabolism from fatty acid" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) biosynthesis from fatty acid" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) formation from fatty acid" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) synthesis from fatty acid" EXACT [GOC:TermGenie]
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process

[Term]
id: GO:1902926
name: inulin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410]
comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410.
synonym: "inulin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010145 ! fructan metabolic process

[Term]
id: GO:1902927
name: inulin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410]
comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410.
synonym: "inulin breakdown" EXACT [GOC:TermGenie]
synonym: "inulin catabolism" EXACT [GOC:TermGenie]
synonym: "inulin degradation" EXACT [GOC:TermGenie]
is_a: GO:0010147 ! fructan catabolic process
is_a: GO:1902926 ! inulin metabolic process

[Term]
id: GO:1902928
name: inulin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410]
comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410.
synonym: "inulin anabolism" EXACT [GOC:TermGenie]
synonym: "inulin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inulin formation" EXACT [GOC:TermGenie]
synonym: "inulin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010146 ! fructan biosynthetic process
is_a: GO:1902926 ! inulin metabolic process

[Term]
id: GO:1902929
name: plasma membrane of growing cell tip
namespace: cellular_component
def: "Any plasma membrane part that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:17085965]
synonym: "growing cell tip plasma membrane part" EXACT [GOC:TermGenie]
synonym: "plasma membrane part of growing cell end" EXACT [GOC:TermGenie]
synonym: "plasma membrane part of growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:0031520 ! plasma membrane of cell tip
relationship: part_of GO:0035838 ! growing cell tip

[Term]
id: GO:1902930
name: regulation of alcohol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]
synonym: "regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of solventogenesis" BROAD []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:1902931
name: negative regulation of alcohol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]
synonym: "down regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of alcohol anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol formation" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of solventogenesis" BROAD []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: negatively_regulates GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:1902932
name: positive regulation of alcohol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]
synonym: "activation of alcohol anabolism" NARROW [GOC:TermGenie]
synonym: "activation of alcohol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of alcohol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of alcohol formation" NARROW [GOC:TermGenie]
synonym: "activation of alcohol synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of solventogenesis" BROAD []
synonym: "up regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: positively_regulates GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:1902933
name: isopentenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564]
synonym: "isopentenol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0120254 ! olefinic compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:1902934
name: isopentenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564]
synonym: "isopentenol anabolism" EXACT [GOC:TermGenie]
synonym: "isopentenol biosynthesis" EXACT [GOC:TermGenie]
synonym: "isopentenol formation" EXACT [GOC:TermGenie]
synonym: "isopentenol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1902933 ! isopentenol metabolic process

[Term]
id: GO:1902935
name: protein localization to septin ring
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a septin ring." [GO_REF:0000087, GOC:TermGenie, PMID:16325501]
synonym: "protein localisation in septin ring" EXACT [GOC:TermGenie]
synonym: "protein localisation to septin ring" EXACT [GOC:TermGenie]
synonym: "protein localization in septin ring" EXACT [GOC:TermGenie]
is_a: GO:0044380 ! protein localization to cytoskeleton
is_a: GO:0072697 ! protein localization to cell cortex

[Term]
id: GO:1902936
name: phosphatidylinositol bisphosphate binding
namespace: molecular_function
def: "Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]
comment: An example of this is KCNJ2 in human (P63252) in PMID:18690034 (inferred from direct assay)
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:1902937
name: inward rectifier potassium channel complex
namespace: cellular_component
def: "A protein complex which is capable of inward rectifier potassium channel activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16834334]
comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay).
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:1902938
name: obsolete regulation of intracellular calcium activated chloride channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]
comment: The reason for obsoletion is that this term represents regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:1902939
name: obsolete negative regulation of intracellular calcium activated chloride channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]
comment: The reason for obsoletion is that this term represents regulation of a molecular function.
synonym: "down regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902940
name: obsolete positive regulation of intracellular calcium activated chloride channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]
comment: The reason for obsoletion is that this term represents regulation of a molecular function.
synonym: "activation of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902941
name: regulation of voltage-gated chloride channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]
subset: gocheck_obsoletion_candidate
synonym: "regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:2001225 ! regulation of chloride transport

[Term]
id: GO:1902942
name: obsolete negative regulation of voltage-gated chloride channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902943
name: positive regulation of voltage-gated chloride channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]
subset: gocheck_obsoletion_candidate
synonym: "activation of voltage gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901529 ! positive regulation of anion channel activity
is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport

[Term]
id: GO:1902944
name: aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: molecular_function
def: "Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:10206644, PMID:24577224]
synonym: "aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
is_a: GO:0004190 ! aspartic-type endopeptidase activity

[Term]
id: GO:1902945
name: metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: molecular_function
def: "Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:14598310, PMID:17855360]
synonym: "metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie]
xref: Reactome:R-HSA-9010034 "ADAM10:Zn2+:TSPANs cleaves APP(18-770)"
is_a: GO:0004222 ! metalloendopeptidase activity

[Term]
id: GO:1902946
name: protein localization to early endosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an early endosome." [GO_REF:0000087, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "protein localization in early endosome" EXACT [GOC:TermGenie]
is_a: GO:0036010 ! protein localization to endosome

[Term]
id: GO:1902947
name: regulation of tau-protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]
subset: gocheck_obsoletion_candidate
synonym: "regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:tau-protein O-phosphotransferase activity" BROAD [GOC:TermGenie]
synonym: "regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "regulation of GSK" RELATED [GOC:TermGenie]
synonym: "regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of STK31" RELATED [GOC:TermGenie]
synonym: "regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of TPK" RELATED [GOC:TermGenie]
synonym: "regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "regulation of TTK" RELATED [GOC:TermGenie]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:1902948
name: negative regulation of tau-protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "down regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "down regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GSK" RELATED [GOC:TermGenie]
synonym: "down regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of STK31" RELATED [GOC:TermGenie]
synonym: "down regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "down regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "down regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of TPK" RELATED [GOC:TermGenie]
synonym: "down regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "down regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "down regulation of TTK" RELATED [GOC:TermGenie]
synonym: "down-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "down-regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "down-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GSK" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of STK31" RELATED [GOC:TermGenie]
synonym: "down-regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of TPK" RELATED [GOC:TermGenie]
synonym: "down-regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "down-regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "down-regulation of TTK" RELATED [GOC:TermGenie]
synonym: "downregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "downregulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "downregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GSK" RELATED [GOC:TermGenie]
synonym: "downregulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of STK31" RELATED [GOC:TermGenie]
synonym: "downregulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "downregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "downregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of TPK" RELATED [GOC:TermGenie]
synonym: "downregulation of TPK I" RELATED [GOC:TermGenie]
synonym: "downregulation of TPK II" RELATED [GOC:TermGenie]
synonym: "downregulation of TTK" RELATED [GOC:TermGenie]
synonym: "inhibition of [Tau protein] kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "inhibition of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "inhibition of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GSK" RELATED [GOC:TermGenie]
synonym: "inhibition of protein tau kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of STK31" RELATED [GOC:TermGenie]
synonym: "inhibition of tau kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau protein kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-protein kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TPK" RELATED [GOC:TermGenie]
synonym: "inhibition of TPK I" RELATED [GOC:TermGenie]
synonym: "inhibition of TPK II" RELATED [GOC:TermGenie]
synonym: "inhibition of TTK" RELATED [GOC:TermGenie]
synonym: "negative regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "negative regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "negative regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GSK" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of STK31" RELATED [GOC:TermGenie]
synonym: "negative regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of TPK" RELATED [GOC:TermGenie]
synonym: "negative regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "negative regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "negative regulation of TTK" RELATED [GOC:TermGenie]
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
is_a: GO:1902947 ! regulation of tau-protein kinase activity

[Term]
id: GO:1902949
name: positive regulation of tau-protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]
subset: gocheck_obsoletion_candidate
synonym: "activation of [Tau protein] kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "activation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "activation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "activation of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie]
synonym: "activation of GSK" RELATED [GOC:TermGenie]
synonym: "activation of protein tau kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of STK31" RELATED [GOC:TermGenie]
synonym: "activation of tau kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of tau protein kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-protein kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of TPK" RELATED [GOC:TermGenie]
synonym: "activation of TPK I" RELATED [GOC:TermGenie]
synonym: "activation of TPK II" RELATED [GOC:TermGenie]
synonym: "activation of TTK" RELATED [GOC:TermGenie]
synonym: "positive regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "positive regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "positive regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GSK" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of STK31" RELATED [GOC:TermGenie]
synonym: "positive regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of TPK" RELATED [GOC:TermGenie]
synonym: "positive regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "positive regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "positive regulation of TTK" RELATED [GOC:TermGenie]
synonym: "up regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "up regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "up regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GSK" RELATED [GOC:TermGenie]
synonym: "up regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of STK31" RELATED [GOC:TermGenie]
synonym: "up regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "up regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "up regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of TPK" RELATED [GOC:TermGenie]
synonym: "up regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "up regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "up regulation of TTK" RELATED [GOC:TermGenie]
synonym: "up-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "up-regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "up-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GSK" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of STK31" RELATED [GOC:TermGenie]
synonym: "up-regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of TPK" RELATED [GOC:TermGenie]
synonym: "up-regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "up-regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "up-regulation of TTK" RELATED [GOC:TermGenie]
synonym: "upregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "upregulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "upregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GSK" RELATED [GOC:TermGenie]
synonym: "upregulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of STK31" RELATED [GOC:TermGenie]
synonym: "upregulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "upregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "upregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of TPK" RELATED [GOC:TermGenie]
synonym: "upregulation of TPK I" RELATED [GOC:TermGenie]
synonym: "upregulation of TPK II" RELATED [GOC:TermGenie]
synonym: "upregulation of TTK" RELATED [GOC:TermGenie]
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:1902947 ! regulation of tau-protein kinase activity

[Term]
id: GO:1902950
name: regulation of dendritic spine maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]
is_a: GO:0099175 ! regulation of postsynapse organization
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
relationship: regulates GO:0097062 ! dendritic spine maintenance

[Term]
id: GO:1902951
name: negative regulation of dendritic spine maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]
synonym: "down regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of dendritic spine maintenance" NARROW [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1902950 ! regulation of dendritic spine maintenance
relationship: negatively_regulates GO:0097062 ! dendritic spine maintenance

[Term]
id: GO:1902952
name: positive regulation of dendritic spine maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]
synonym: "activation of dendritic spine maintenance" NARROW [GOC:TermGenie]
synonym: "up regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:1902950 ! regulation of dendritic spine maintenance
relationship: positively_regulates GO:0097062 ! dendritic spine maintenance

[Term]
id: GO:1902953
name: positive regulation of ER to Golgi vesicle-mediated transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:17855360]
synonym: "activation of endoplasmic reticulum to Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "activation of ER to Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of ER to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "activation of rough endoplasmic reticulum to cis-Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "activation of rough ER to cis-Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of rough ER to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport
relationship: positively_regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport

[Term]
id: GO:1902954
name: regulation of early endosome to recycling endosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0061502 ! early endosome to recycling endosome transport

[Term]
id: GO:1902955
name: positive regulation of early endosome to recycling endosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "activation of early endosome to recycling endosome transport" NARROW [GOC:TermGenie]
synonym: "up regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie]
synonym: "upregulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1902954 ! regulation of early endosome to recycling endosome transport
relationship: positively_regulates GO:0061502 ! early endosome to recycling endosome transport

[Term]
id: GO:1902956
name: regulation of mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]
synonym: "regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
is_a: GO:1903715 ! regulation of aerobic respiration
relationship: regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone

[Term]
id: GO:1902957
name: negative regulation of mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]
synonym: "down regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "down regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "down-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "down-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "downregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "downregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "inhibition of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "inhibition of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "negative regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "negative regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone
is_a: GO:1905447 ! negative regulation of mitochondrial ATP synthesis coupled electron transport
relationship: negatively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone

[Term]
id: GO:1902958
name: positive regulation of mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]
synonym: "activation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "activation of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "activation of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "positive regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "positive regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "up regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "upregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "upregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
is_a: GO:1901857 ! positive regulation of cellular respiration
is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone
relationship: positively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone

[Term]
id: GO:1902959
name: regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]
subset: gocheck_obsoletion_candidate
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0052548 ! regulation of endopeptidase activity
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
is_a: GO:1905245 ! regulation of aspartic-type peptidase activity

[Term]
id: GO:1902960
name: negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process
is_a: GO:1905246 ! negative regulation of aspartic-type peptidase activity

[Term]
id: GO:1902961
name: positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]
subset: gocheck_obsoletion_candidate
synonym: "activation of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process
is_a: GO:1905247 ! positive regulation of aspartic-type peptidase activity

[Term]
id: GO:1902962
name: regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]
subset: gocheck_obsoletion_candidate
synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
is_a: GO:1904683 ! regulation of metalloendopeptidase activity

[Term]
id: GO:1902963
name: obsolete negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902964
name: obsolete positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1902965
name: regulation of protein localization to early endosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
is_a: GO:1905666 ! regulation of protein localization to endosome
relationship: regulates GO:1902946 ! protein localization to early endosome

[Term]
id: GO:1902966
name: positive regulation of protein localization to early endosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "activation of protein localisation in early endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to early endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in early endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to early endosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to early endosome" EXACT [GOC:TermGenie]
is_a: GO:1902965 ! regulation of protein localization to early endosome
is_a: GO:1905668 ! positive regulation of protein localization to endosome
relationship: positively_regulates GO:1902946 ! protein localization to early endosome

[Term]
id: GO:1902967
name: protein localization to mitotic spindle midzone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle midzone." [GO_REF:0000087, GOC:TermGenie, PMID:16824200]
synonym: "protein localisation in mitotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localisation to mitotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localization in mitotic spindle midzone" EXACT [GOC:TermGenie]
is_a: GO:1902480 ! protein localization to mitotic spindle

[Term]
id: GO:1902969
name: mitotic DNA replication
namespace: biological_process
def: "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "mitotic cell cycle DNA replication" EXACT []
synonym: "mitotic nuclear cell cycle DNA replication" EXACT []
synonym: "nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED []
is_a: GO:0033260 ! nuclear DNA replication
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:1902970
name: premeiotic DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in meiotic cell cycle DNA replication" EXACT []
synonym: "DNA duplex unwinding involved in meiotic DNA replication" EXACT []
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding
relationship: part_of GO:0006279 ! premeiotic DNA replication

[Term]
id: GO:1902971
name: mitotic DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in mitotic cell cycle DNA replication" EXACT []
synonym: "DNA duplex unwinding involved in mitotic DNA replication" EXACT []
is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1902972
name: premeiotic DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA ligation involved in meiotic cell cycle DNA replication" RELATED []
synonym: "DNA ligation involved in meiotic DNA replication" EXACT []
is_a: GO:1902333 ! nuclear DNA replication DNA ligation
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0006279 ! premeiotic DNA replication

[Term]
id: GO:1902973
name: mitotic DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA ligation involved in mitotic cell cycle DNA replication" EXACT []
synonym: "DNA ligation involved in mitotic DNA replication" EXACT []
is_a: GO:1902333 ! nuclear DNA replication DNA ligation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1902974
name: meiotic DNA replication initiation
namespace: biological_process
alt_id: GO:0072691
def: "Any DNA replication initiation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie, PMID:10888871]
synonym: "DNA replication initiation involved in meiotic cell cycle DNA replication" EXACT []
synonym: "DNA replication initiation involved in meiotic DNA replication" EXACT []
synonym: "initiation of meiotic DNA synthesis" RELATED [GOC:mah]
synonym: "initiation of premeiotic DNA replication" RELATED []
synonym: "initiation of premeiotic DNA synthesis" RELATED [GOC:mah]
synonym: "premeiotic DNA replication initiation" RELATED [GOC:mah]
is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation
is_a: GO:1903046 ! meiotic cell cycle process

[Term]
id: GO:1902975
name: mitotic DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1902976
name: premeiotic DNA replication preinitiation complex assembly
namespace: biological_process
def: "Any DNA replication preinitiation complex assembly that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication preinitiation complex formation involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-IC complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0071163 ! DNA replication preinitiation complex assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0006279 ! premeiotic DNA replication

[Term]
id: GO:1902977
name: mitotic DNA replication preinitiation complex assembly
namespace: biological_process
def: "Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication preinitiation complex formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-IC complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0071163 ! DNA replication preinitiation complex assembly
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1902978
name: premeiotic DNA replication termination
namespace: biological_process
def: "Any DNA replication termination involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication termination involved in meiotic cell cycle DNA replication" EXACT []
synonym: "DNA replication termination involved in meiotic DNA replication" EXACT []
is_a: GO:1902317 ! nuclear DNA replication termination
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0006279 ! premeiotic DNA replication

[Term]
id: GO:1902979
name: mitotic DNA replication termination
namespace: biological_process
def: "Any DNA replication termination involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication termination involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:1902317 ! nuclear DNA replication termination
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1902980
name: obsolete synthesis of RNA primer involved in premeiotic DNA replication
namespace: biological_process
def: "OBSOLETE. Any synthesis of RNA primer involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
comment: The reason for obsoletion is that these are precomposed terms that should be captured as GO-CAM models.
synonym: "synthesis of RNA primer involved in meiotic cell cycle DNA replication" EXACT []
is_obsolete: true

[Term]
id: GO:1902981
name: obsolete synthesis of RNA primer involved in mitotic DNA replication
namespace: biological_process
alt_id: GO:1903458
def: "OBSOLETE. Any synthesis of RNA primer involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
comment: The reason for obsoletion is that these are precomposed terms that should be captured as GO-CAM models.
synonym: "synthesis of RNA primer involved in mitotic cell cycle DNA replication" EXACT []
is_obsolete: true

[Term]
id: GO:1902982
name: DNA strand elongation involved in premeiotic DNA replication
namespace: biological_process
def: "Any DNA strand elongation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA strand elongation involved in meiotic cell cycle DNA replication" EXACT []
is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0006279 ! premeiotic DNA replication

[Term]
id: GO:1902983
name: DNA strand elongation involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA strand elongation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA strand elongation involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1902984
name: pre-replicative complex assembly involved in premeiotic DNA replication
namespace: biological_process
def: "Any pre-replicative complex assembly involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "nuclear pre-replicative complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-RC complex assembly involved in meiosis" BROAD [GOC:TermGenie]
synonym: "pre-replicative complex assembly involved in meiosis" BROAD [GOC:TermGenie]
synonym: "pre-replicative complex assembly involved in meiotic cell cycle DNA replication" EXACT []
synonym: "pre-replicative complex formation involved in meiosis" BROAD [GOC:TermGenie]
is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0006279 ! premeiotic DNA replication

[Term]
id: GO:1902985
name: mitotic pre-replicative complex assembly
namespace: biological_process
def: "Any pre-replicative complex assembly involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "nuclear pre-replicative complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-replicative complex assembly involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1902986
name: regulation of lysine biosynthetic process via aminoadipic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464]
synonym: "regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:1902987
name: negative regulation of lysine biosynthetic process via aminoadipic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464]
synonym: "down regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of lysine anabolism via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthesis, aminoadipic acid pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthesis, aminoadipic pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthetic process via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthetic process, aminoadipic acid pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthetic process, aminoadipic pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine formation via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine synthesis via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "negative regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:1902988
name: neurofibrillary tangle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle." [GO_REF:0000079, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780, PMID:24154541]
comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
synonym: "flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0070841 ! inclusion body assembly

[Term]
id: GO:1902989
name: meiotic telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any telomere maintenance via semi-conservative replication that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "equal telomere replication involved in meiotic cell cycle" RELATED [GOC:TermGenie]
synonym: "telomeric fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie]
synonym: "telomeric replication fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie]
is_a: GO:0032201 ! telomere maintenance via semi-conservative replication
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle

[Term]
id: GO:1902990
name: mitotic telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "equal telomere replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "telomeric fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "telomeric replication fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie]
is_a: GO:0032201 ! telomere maintenance via semi-conservative replication
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:1902991
name: regulation of amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]
comment: An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
synonym: "regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0042987 ! amyloid precursor protein catabolic process

[Term]
id: GO:1902992
name: negative regulation of amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]
synonym: "down regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of APP catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
relationship: negatively_regulates GO:0042987 ! amyloid precursor protein catabolic process

[Term]
id: GO:1902993
name: positive regulation of amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]
synonym: "activation of amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of APP catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
relationship: positively_regulates GO:0042987 ! amyloid precursor protein catabolic process

[Term]
id: GO:1902994
name: regulation of phospholipid efflux
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]
synonym: "regulation of phospholipid export" EXACT [GOC:TermGenie]
is_a: GO:2001138 ! regulation of phospholipid transport
relationship: regulates GO:0033700 ! phospholipid efflux

[Term]
id: GO:1902995
name: positive regulation of phospholipid efflux
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]
synonym: "activation of phospholipid efflux" NARROW [GOC:TermGenie]
synonym: "activation of phospholipid export" NARROW [GOC:TermGenie]
synonym: "positive regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid export" EXACT [GOC:TermGenie]
is_a: GO:1902994 ! regulation of phospholipid efflux
is_a: GO:2001140 ! positive regulation of phospholipid transport
relationship: positively_regulates GO:0033700 ! phospholipid efflux

[Term]
id: GO:1902996
name: regulation of neurofibrillary tangle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]
synonym: "regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0090083 ! regulation of inclusion body assembly
relationship: regulates GO:1902988 ! neurofibrillary tangle assembly

[Term]
id: GO:1902997
name: negative regulation of neurofibrillary tangle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]
synonym: "down regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "down regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "down regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "downregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "downregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0090084 ! negative regulation of inclusion body assembly
is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly
relationship: negatively_regulates GO:1902988 ! neurofibrillary tangle assembly

[Term]
id: GO:1902998
name: positive regulation of neurofibrillary tangle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]
synonym: "activation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "activation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "activation of neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "activation of neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "activation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "activation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "upregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "upregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0090261 ! positive regulation of inclusion body assembly
is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly
relationship: positively_regulates GO:1902988 ! neurofibrillary tangle assembly

[Term]
id: GO:1902999
name: negative regulation of phospholipid efflux
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]
synonym: "down regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipid efflux" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipid export" NARROW [GOC:TermGenie]
synonym: "negative regulation of phospholipid export" EXACT [GOC:TermGenie]
is_a: GO:1902994 ! regulation of phospholipid efflux
is_a: GO:2001139 ! negative regulation of phospholipid transport
relationship: negatively_regulates GO:0033700 ! phospholipid efflux

[Term]
id: GO:1903000
name: regulation of lipid transport across blood-brain barrier
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]
synonym: "regulation of lipid transport across blood brain barrier" EXACT []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0150200 ! regulation of transport across blood-brain barrier
relationship: regulates GO:1990379 ! lipid transport across blood-brain barrier

[Term]
id: GO:1903001
name: negative regulation of lipid transport across blood-brain barrier
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]
synonym: "down regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid transport across blood brain barrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of lipid transport across blood brain barrier" EXACT []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0150202 ! negative regulation of transport across blood-brain barrier
is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier
relationship: negatively_regulates GO:1990379 ! lipid transport across blood-brain barrier

[Term]
id: GO:1903002
name: positive regulation of lipid transport across blood-brain barrier
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]
synonym: "activation of lipid transport across blood brain barrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of lipid transport across blood brain barrier" EXACT []
synonym: "up regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0150201 ! positive regulation of transport across blood-brain barrier
is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier
relationship: positively_regulates GO:1990379 ! lipid transport across blood-brain barrier

[Term]
id: GO:1903003
name: positive regulation of protein deubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
synonym: "activation of deubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein deubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein deubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein deubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein deubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein deubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein deubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0090085 ! regulation of protein deubiquitination
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
relationship: positively_regulates GO:0016579 ! protein deubiquitination

[Term]
id: GO:1903004
name: regulation of protein K63-linked deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
is_a: GO:0090085 ! regulation of protein deubiquitination
relationship: regulates GO:0070536 ! protein K63-linked deubiquitination

[Term]
id: GO:1903005
name: negative regulation of protein K63-linked deubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
synonym: "down regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of protein K63-linked deubiquitination" NARROW [GOC:TermGenie]
is_a: GO:0090086 ! negative regulation of protein deubiquitination
is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination
relationship: negatively_regulates GO:0070536 ! protein K63-linked deubiquitination

[Term]
id: GO:1903006
name: positive regulation of protein K63-linked deubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
synonym: "activation of protein K63-linked deubiquitination" NARROW [GOC:TermGenie]
synonym: "up regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1903003 ! positive regulation of protein deubiquitination
is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination
relationship: positively_regulates GO:0070536 ! protein K63-linked deubiquitination

[Term]
id: GO:1903007
name: positive regulation of Lys63-specific deubiquitinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
subset: gocheck_obsoletion_candidate
synonym: "activation of Lys63-specific deubiquitinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:1903006 ! positive regulation of protein K63-linked deubiquitination

[Term]
id: GO:1903008
name: organelle disassembly
namespace: biological_process
def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]
synonym: "organelle degradation" EXACT []
is_a: GO:0006996 ! organelle organization
is_a: GO:0022411 ! cellular component disassembly

[Term]
id: GO:1903009
name: proteasome complex disassembly
namespace: biological_process
def: "The disaggregation of a proteasome complex into its constituent components." [GO_REF:0000079, GOC:TermGenie]
synonym: "26S proteasome disassembly" NARROW [GOC:TermGenie]
synonym: "proteasome degradation" EXACT []
synonym: "proteasome disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:1903010
name: regulation of bone development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0060348 ! bone development

[Term]
id: GO:1903011
name: negative regulation of bone development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "down regulation of bone development" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "downregulation of bone development" EXACT [GOC:TermGenie]
synonym: "inhibition of bone development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
relationship: negatively_regulates GO:0060348 ! bone development

[Term]
id: GO:1903012
name: positive regulation of bone development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "activation of bone development" NARROW [GOC:TermGenie]
synonym: "up regulation of bone development" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "upregulation of bone development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
relationship: positively_regulates GO:0060348 ! bone development

[Term]
id: GO:1903013
name: response to differentiation-inducing factor 1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]
synonym: "DIF-1" RELATED []
synonym: "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one" EXACT []
synonym: "response to DIF-1" RELATED []
synonym: "response to DIF1" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1903014
name: cellular response to differentiation-inducing factor 1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]
synonym: "cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one" EXACT []
synonym: "cellular response to DIF-1" RELATED []
synonym: "cellular response to DIF1" RELATED []
synonym: "DIF-1" RELATED []
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1903013 ! response to differentiation-inducing factor 1

[Term]
id: GO:1903015
name: regulation of exo-alpha-sialidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA)
subset: gocheck_obsoletion_candidate
synonym: "regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sialidase activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:1903016
name: negative regulation of exo-alpha-sialidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA)
subset: gocheck_obsoletion_candidate
synonym: "down regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acetylneuraminidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of alpha-neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of exo-alpha-sialidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sialidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sialidase activity" EXACT [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity

[Term]
id: GO:1903017
name: positive regulation of exo-alpha-sialidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA)
subset: gocheck_obsoletion_candidate
synonym: "activation of acetylneuraminidase activity" NARROW [GOC:TermGenie]
synonym: "activation of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of alpha-neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "activation of exo-alpha-sialidase activity" NARROW [GOC:TermGenie]
synonym: "activation of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "activation of sialidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sialidase activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity

[Term]
id: GO:1903018
name: regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:1903019
name: negative regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
relationship: negatively_regulates GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:1903020
name: positive regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
relationship: positively_regulates GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:1903021
name: regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046]
subset: gocheck_obsoletion_candidate
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:1903022
name: obsolete positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" NARROW [GOC:TermGenie]
synonym: "up regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903023
name: regulation of ascospore-type prospore membrane formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of an ascospore-type prospore membrane." [GO_REF:0000058, GOC:TermGenie, PMID:11405625]
synonym: "regulation of ascospore-type prospore membrane assembly" RELATED []
synonym: "regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of FSM formation" EXACT [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0032120 ! ascospore-type prospore membrane formation

[Term]
id: GO:1903024
name: positive regulation of ascospore-type prospore membrane formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of an ascospore-type prospore membrane." [GO_REF:0000058, GOC:TermGenie, PMID:11405625]
synonym: "activation of ascospore-type prospore membrane assembly" NARROW [GOC:TermGenie]
synonym: "activation of forespore membrane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of forespore membrane formation" NARROW [GOC:TermGenie]
synonym: "activation of FSM assembly" NARROW [GOC:TermGenie]
synonym: "activation of FSM biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of FSM formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ascospore-type prospore membrane assembly" RELATED []
synonym: "positive regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of FSM formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "up regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of FSM formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of FSM formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "upregulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of FSM formation" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0075296 ! positive regulation of ascospore formation
is_a: GO:1903023 ! regulation of ascospore-type prospore membrane formation
relationship: positively_regulates GO:0032120 ! ascospore-type prospore membrane formation

[Term]
id: GO:1903025
name: regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]
subset: gocheck_do_not_annotate
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding

[Term]
id: GO:1903026
name: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]
subset: gocheck_do_not_annotate
synonym: "down regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding

[Term]
id: GO:1903027
name: regulation of opsonization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0008228 ! opsonization

[Term]
id: GO:1903028
name: positive regulation of opsonization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221]
synonym: "activation of opsonization" NARROW [GOC:TermGenie]
synonym: "up regulation of opsonization" EXACT [GOC:TermGenie]
synonym: "up-regulation of opsonization" EXACT [GOC:TermGenie]
synonym: "upregulation of opsonization" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:1903027 ! regulation of opsonization
relationship: positively_regulates GO:0008228 ! opsonization

[Term]
id: GO:1903031
name: regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
subset: gocheck_do_not_annotate
is_a: GO:1904526 ! regulation of microtubule binding

[Term]
id: GO:1903032
name: negative regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
subset: gocheck_do_not_annotate
synonym: "down regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule plus-end binding" NARROW [GOC:TermGenie]
is_a: GO:1903031 ! regulation of microtubule plus-end binding
is_a: GO:1904527 ! negative regulation of microtubule binding

[Term]
id: GO:1903033
name: positive regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
subset: gocheck_do_not_annotate
synonym: "activation of microtubule plus-end binding" NARROW [GOC:TermGenie]
synonym: "up regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
is_a: GO:1903031 ! regulation of microtubule plus-end binding
is_a: GO:1904528 ! positive regulation of microtubule binding

[Term]
id: GO:1903034
name: regulation of response to wounding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535]
synonym: "regulation of physiological response to wounding" EXACT [GOC:TermGenie]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0009611 ! response to wounding

[Term]
id: GO:1903035
name: negative regulation of response to wounding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535]
synonym: "down regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "down regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "downregulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "inhibition of physiological response to wounding" NARROW [GOC:TermGenie]
synonym: "inhibition of response to wounding" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological response to wounding" EXACT [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1903034 ! regulation of response to wounding
relationship: negatively_regulates GO:0009611 ! response to wounding

[Term]
id: GO:1903036
name: positive regulation of response to wounding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535]
synonym: "activation of physiological response to wounding" NARROW [GOC:TermGenie]
synonym: "activation of response to wounding" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "up regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "upregulation of response to wounding" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903034 ! regulation of response to wounding
relationship: positively_regulates GO:0009611 ! response to wounding

[Term]
id: GO:1903037
name: regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0007159 ! leukocyte cell-cell adhesion

[Term]
id: GO:1903038
name: negative regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
relationship: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion

[Term]
id: GO:1903039
name: positive regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
relationship: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion

[Term]
id: GO:1903040
name: exon-exon junction complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an exon-exon junction complex." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:17606899]
synonym: "EJC assembly" EXACT [GOC:TermGenie]
synonym: "EJC formation" EXACT [GOC:TermGenie]
synonym: "exon-exon junction complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1903041
name: regulation of chondrocyte hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061181 ! regulation of chondrocyte development
relationship: regulates GO:0003415 ! chondrocyte hypertrophy

[Term]
id: GO:1903042
name: negative regulation of chondrocyte hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]
synonym: "down regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of chondrocyte hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0061182 ! negative regulation of chondrocyte development
is_a: GO:1903041 ! regulation of chondrocyte hypertrophy
relationship: negatively_regulates GO:0003415 ! chondrocyte hypertrophy

[Term]
id: GO:1903043
name: positive regulation of chondrocyte hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]
synonym: "activation of chondrocyte hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1902761 ! positive regulation of chondrocyte development
is_a: GO:1903041 ! regulation of chondrocyte hypertrophy
relationship: positively_regulates GO:0003415 ! chondrocyte hypertrophy

[Term]
id: GO:1903044
name: protein localization to membrane raft
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a membrane raft." [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744]
synonym: "protein localisation in membrane raft" EXACT [GOC:TermGenie]
synonym: "protein localisation to membrane raft" EXACT [GOC:TermGenie]
synonym: "protein localization in membrane raft" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane

[Term]
id: GO:1903045
name: neural crest cell migration involved in sympathetic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129]
comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development
is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development
relationship: part_of GO:0048485 ! sympathetic nervous system development

[Term]
id: GO:1903046
name: meiotic cell cycle process
namespace: biological_process
def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
subset: goslim_pombe
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:1903047
name: mitotic cell cycle process
namespace: biological_process
def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:1903048
name: regulation of acetylcholine-gated cation channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690]
subset: gocheck_obsoletion_candidate
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
is_a: GO:0098962 ! regulation of postsynaptic neurotransmitter receptor activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1903049
name: obsolete negative regulation of acetylcholine-gated cation channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acetylcholine-gated cation channel activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903050
name: regulation of proteolysis involved in protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]
comment: overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP)
synonym: "regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "regulation of proteolysis involved in cellular protein catabolic process" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
relationship: regulates GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:1903051
name: negative regulation of proteolysis involved in protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]
comment: Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
synonym: "down regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of proteolysis involved in cellular protein catabolic process" EXACT []
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process
relationship: negatively_regulates GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:1903052
name: positive regulation of proteolysis involved in protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]
comment: overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP)
synonym: "activation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of proteolysis involved in cellular protein catabolic process" EXACT []
synonym: "up regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process
relationship: positively_regulates GO:0051603 ! proteolysis involved in protein catabolic process

[Term]
id: GO:1903053
name: regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0030198 ! extracellular matrix organization

[Term]
id: GO:1903054
name: negative regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
relationship: negatively_regulates GO:0030198 ! extracellular matrix organization

[Term]
id: GO:1903055
name: positive regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
relationship: positively_regulates GO:0030198 ! extracellular matrix organization

[Term]
id: GO:1903056
name: regulation of melanosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]
comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles
synonym: "regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0032438 ! melanosome organization

[Term]
id: GO:1903057
name: negative regulation of melanosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]
comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles.
synonym: "down regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "down regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "downregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of melanosome organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of melanosome organization" NARROW [GOC:TermGenie]
synonym: "inhibition of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1903056 ! regulation of melanosome organization
relationship: negatively_regulates GO:0032438 ! melanosome organization

[Term]
id: GO:1903058
name: positive regulation of melanosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]
comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles.
synonym: "activation of melanosome organisation" NARROW [GOC:TermGenie]
synonym: "activation of melanosome organization" NARROW [GOC:TermGenie]
synonym: "activation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "up regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "upregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1903056 ! regulation of melanosome organization
relationship: positively_regulates GO:0032438 ! melanosome organization

[Term]
id: GO:1903059
name: regulation of protein lipidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]
subset: gocheck_obsoletion_candidate
synonym: "regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
relationship: regulates GO:0006497 ! protein lipidation

[Term]
id: GO:1903060
name: negative regulation of protein lipidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "down regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid:protein modification" NARROW [GOC:TermGenie]
synonym: "inhibition of protein amino acid lipidation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein lipidation" NARROW [GOC:TermGenie]
synonym: "negative regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process
is_a: GO:1903059 ! regulation of protein lipidation
relationship: negatively_regulates GO:0006497 ! protein lipidation

[Term]
id: GO:1903061
name: positive regulation of protein lipidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]
subset: gocheck_obsoletion_candidate
synonym: "activation of lipid:protein modification" NARROW [GOC:TermGenie]
synonym: "activation of protein amino acid lipidation" NARROW [GOC:TermGenie]
synonym: "activation of protein lipidation" NARROW [GOC:TermGenie]
synonym: "positive regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein lipidation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0050747 ! positive regulation of lipoprotein metabolic process
is_a: GO:1903059 ! regulation of protein lipidation
relationship: positively_regulates GO:0006497 ! protein lipidation

[Term]
id: GO:1903062
name: regulation of reverse cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: regulates GO:0043691 ! reverse cholesterol transport

[Term]
id: GO:1903063
name: negative regulation of reverse cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]
synonym: "down regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "downregulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "inhibition of reverse cholesterol transport" NARROW [GOC:TermGenie]
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:1903062 ! regulation of reverse cholesterol transport
relationship: negatively_regulates GO:0043691 ! reverse cholesterol transport

[Term]
id: GO:1903064
name: positive regulation of reverse cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]
synonym: "activation of reverse cholesterol transport" NARROW [GOC:TermGenie]
synonym: "up regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "upregulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:1903062 ! regulation of reverse cholesterol transport
relationship: positively_regulates GO:0043691 ! reverse cholesterol transport

[Term]
id: GO:1903065
name: obsolete protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "OBSOLETE. Any protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT []
is_obsolete: true

[Term]
id: GO:1903066
name: regulation of protein localization to cell tip
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432]
synonym: "regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:1990151 ! protein localization to cell tip

[Term]
id: GO:1903067
name: negative regulation of protein localization to cell tip
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432]
synonym: "down regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell tip" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell tip" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
is_a: GO:1903066 ! regulation of protein localization to cell tip
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:1990151 ! protein localization to cell tip

[Term]
id: GO:1903068
name: positive regulation of protein localization to cell tip
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432]
synonym: "activation of protein localisation to cell tip" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell tip" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell tip" EXACT [GOC:TermGenie]
is_a: GO:1903066 ! regulation of protein localization to cell tip
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:1990151 ! protein localization to cell tip

[Term]
id: GO:1903069
name: obsolete regulation of ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]
comment: This term was obsoleted because it has identical meaning to another term (positive regulation of ERAD pathway).
is_obsolete: true
replaced_by: GO:1904292

[Term]
id: GO:1903070
name: obsolete negative regulation of ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]
comment: This term was added in error, it is identical to "negative regulation of ERAD pathway".
is_obsolete: true
replaced_by: GO:1904293

[Term]
id: GO:1903071
name: obsolete positive regulation of ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]
comment: This term was obsoleted because it has identical meaning to another term (positive regulation of ERAD pathway).
is_obsolete: true
replaced_by: GO:1904294

[Term]
id: GO:1903072
name: regulation of death-inducing signaling complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "regulation of DISC formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0071550 ! death-inducing signaling complex assembly

[Term]
id: GO:1903073
name: negative regulation of death-inducing signaling complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "down regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DISC formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DISC formation" EXACT [GOC:TermGenie]
synonym: "downregulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DISC formation" EXACT [GOC:TermGenie]
synonym: "inhibition of DD-mediated complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of death domain-mediated complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of death-inducing signaling complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of death-inducing signaling complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of death-inducing signalling complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DISC assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DISC formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of DISC formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1903072 ! regulation of death-inducing signaling complex assembly
is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0071550 ! death-inducing signaling complex assembly

[Term]
id: GO:1903074
name: TRAIL death-inducing signaling complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "TRAIL death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "TRAIL death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "TRAIL death-inducing signalling complex formation" EXACT [GOC:TermGenie]
synonym: "TRAIL DISC assembly" EXACT [GOC:TermGenie]
synonym: "TRAIL DISC formation" EXACT [GOC:TermGenie]
is_a: GO:0071550 ! death-inducing signaling complex assembly
relationship: part_of GO:0036462 ! TRAIL-activated apoptotic signaling pathway

[Term]
id: GO:1903075
name: pyridoxine import across plasma membrane
namespace: biological_process
def: "The directed movement of pyridoxine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:15701794]
synonym: "pyridoxine import into cell" EXACT []
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1903092 ! pyridoxine transmembrane transport

[Term]
id: GO:1903076
name: regulation of protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0090003
alt_id: GO:1905963
def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "regulation of establishment of protein localization in plasma membrane" RELATED []
synonym: "regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie]
synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein targeting to plasma membrane" RELATED []
synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:0072659 ! protein localization to plasma membrane

[Term]
id: GO:1903077
name: negative regulation of protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0090005
alt_id: GO:1905964
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED []
synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein targeting to plasma membrane" RELATED []
synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1905476 ! negative regulation of protein localization to membrane
relationship: negatively_regulates GO:0072659 ! protein localization to plasma membrane

[Term]
id: GO:1903078
name: positive regulation of protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0090004
alt_id: GO:1905965
def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein targeting to plasma membrane" RELATED []
synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1905477 ! positive regulation of protein localization to membrane
relationship: positively_regulates GO:0072659 ! protein localization to plasma membrane

[Term]
id: GO:1903079
name: obsolete negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "OBSOLETE. Any negative regulation of protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT []
is_obsolete: true

[Term]
id: GO:1903080
name: regulation of C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
relationship: regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway

[Term]
id: GO:1903081
name: negative regulation of C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "down regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0070100 ! negative regulation of chemokine-mediated signaling pathway
is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway
relationship: negatively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway

[Term]
id: GO:1903082
name: positive regulation of C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "activation of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie]
synonym: "activation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0070101 ! positive regulation of chemokine-mediated signaling pathway
is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway
relationship: positively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway

[Term]
id: GO:1903083
name: protein localization to condensed chromosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a condensed chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:12707312]
synonym: "protein localisation in condensed chromosome" EXACT [GOC:TermGenie]
synonym: "protein localisation to condensed chromosome" EXACT [GOC:TermGenie]
synonym: "protein localization in condensed chromosome" EXACT [GOC:TermGenie]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:1903084
name: protein localization to condensed nuclear chromosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:12707312]
synonym: "protein localisation in condensed nuclear chromosome" EXACT [GOC:TermGenie]
synonym: "protein localisation to condensed nuclear chromosome" EXACT [GOC:TermGenie]
synonym: "protein localization in condensed nuclear chromosome" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:1903083 ! protein localization to condensed chromosome

[Term]
id: GO:1903085
name: regulation of sinapate ester biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161]
synonym: "regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
relationship: regulates GO:0033525 ! sinapate ester biosynthetic process

[Term]
id: GO:1903086
name: negative regulation of sinapate ester biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161]
synonym: "down regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sinapate ester anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester formation" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1903085 ! regulation of sinapate ester biosynthetic process
relationship: negatively_regulates GO:0033525 ! sinapate ester biosynthetic process

[Term]
id: GO:1903087
name: mitotic spindle pole body duplication
namespace: biological_process
def: "Any spindle pole body duplication that is involved in the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "spindle pole body assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body biogenesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body duplication associated with nuclear envelope involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body duplication in cytoplasm involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body duplication involved in mitotic cell cycle" EXACT []
synonym: "spindle pole body formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body replication involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0030474 ! spindle pole body duplication
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:1903088
name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport
namespace: biological_process
def: "The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24778186]
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:1903089
name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other." [GO_REF:0000066, GOC:TermGenie, PMID:24778186]
synonym: "acadesine transporter activity" EXACT []
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity

[Term]
id: GO:1903090
name: pyridoxal transmembrane transport
namespace: biological_process
def: "The process in which pyridoxal is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
is_a: GO:0031920 ! pyridoxal transport
is_a: GO:0035461 ! vitamin transmembrane transport

[Term]
id: GO:1903091
name: pyridoxamine transmembrane transport
namespace: biological_process
def: "The process in which pyridoxamine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
is_a: GO:0031922 ! pyridoxamine transport
is_a: GO:0035461 ! vitamin transmembrane transport

[Term]
id: GO:1903092
name: pyridoxine transmembrane transport
namespace: biological_process
def: "The process in which pyridoxine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
is_a: GO:0031923 ! pyridoxine transport
is_a: GO:0035461 ! vitamin transmembrane transport

[Term]
id: GO:1903093
name: regulation of protein K48-linked deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
is_a: GO:0090085 ! regulation of protein deubiquitination
relationship: regulates GO:0071108 ! protein K48-linked deubiquitination

[Term]
id: GO:1903094
name: negative regulation of protein K48-linked deubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21097510]
synonym: "down regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of protein K48-linked deubiquitination" NARROW [GOC:TermGenie]
is_a: GO:0090086 ! negative regulation of protein deubiquitination
is_a: GO:1903093 ! regulation of protein K48-linked deubiquitination
relationship: negatively_regulates GO:0071108 ! protein K48-linked deubiquitination

[Term]
id: GO:1903095
name: ribonuclease III complex
namespace: cellular_component
def: "A protein complex which is capable of ribonuclease III activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22393237]
comment: An example of this is RNC in human (Q9NRR4) in PMID:22393237 (inferred from direct assay).
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:1903096
name: protein localization to meiotic spindle midzone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:12707312]
synonym: "protein localisation in meiotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localisation to meiotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localization in meiotic spindle midzone" EXACT [GOC:TermGenie]
is_a: GO:1905359 ! protein localization to meiotic spindle

[Term]
id: GO:1903097
name: obsolete regulation of CENP-A containing nucleosome assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126]
comment: This term has been obsoleted because this process is not known to be regulated.
synonym: "regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0034080

[Term]
id: GO:1903098
name: obsolete negative regulation of CENP-A containing nucleosome assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126]
comment: This term has been obsoleted because this process is not known to be regulated.
synonym: "down regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "down regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "down regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "down regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "down regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "down regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "down regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "down-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "down-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "down-regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "down-regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "down-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "down-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "downregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "downregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "downregulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "downregulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "downregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "downregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "inhibition of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "inhibition of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "inhibition of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "inhibition of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "inhibition of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of centromere-specific histone exchange" NARROW [GOC:TermGenie]
synonym: "inhibition of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "negative regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "negative regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "negative regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "negative regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "negative regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "negative regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903099
name: obsolete positive regulation of CENP-A containing nucleosome assembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126]
comment: This term has been obsoleted because this process is not known to be regulated.
synonym: "activation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "activation of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "activation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "activation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "activation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "activation of centromere-specific histone exchange" NARROW [GOC:TermGenie]
synonym: "activation of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "positive regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "positive regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "positive regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "positive regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "positive regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "positive regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "up regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "up regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "up regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "up regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "up-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up-regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "up-regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "up-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "upregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "upregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "upregulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "upregulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "upregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "upregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903100
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:1903101
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0031161 ! phosphatidylinositol catabolic process
is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

[Term]
id: GO:1903102
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process
is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

[Term]
id: GO:1903103
name: potassium:proton antiporter complex
namespace: cellular_component
def: "A protein complex which is capable of potassium:proton antiporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:21041667]
comment: An example of this is kefC in E. coli (P03819) in PMID:21041667 (inferred from direct assay).
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1903104
name: obsolete regulation of insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560]
comment: This term was obsoleted because it should be represented as a GO-CAM model.
synonym: "regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903105
name: obsolete negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560]
comment: This term was obsoleted because it should be represented as a GO-CAM model.
synonym: "down regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "down regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "down-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "downregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "downregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "downregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "downregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "inhibition of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "inhibition of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "inhibition of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "inhibition of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "negative regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "negative regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "negative regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903106
name: obsolete positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560]
comment: This term was obsoleted because it should be represented as a GO-CAM model.
synonym: "activation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "activation of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "activation of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "activation of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "positive regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "positive regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "positive regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "up regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "up-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "upregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "upregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "upregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "upregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903107
name: obsolete insulin receptor signaling pathway involved in dauer larval development
namespace: biological_process
def: "OBSOLETE. Any insulin receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19853560]
comment: The reason for obsoletion is that this is a pre-composed term that represents a GO-CAM model.
synonym: "daf-2 receptor signaling pathway involved in dauer larval development" NARROW [GOC:TermGenie]
synonym: "insulin receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903108
name: regulation of mitochondrial transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription occurring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609]
synonym: "regulation of transcription from mitochondrial promoter" EXACT []
is_a: GO:0006355 ! regulation of DNA-templated transcription
is_a: GO:0062125 ! regulation of mitochondrial gene expression
relationship: regulates GO:0006390 ! mitochondrial transcription

[Term]
id: GO:1903109
name: positive regulation of mitochondrial transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription occurring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609]
synonym: "activation of mitochondrial transcription" NARROW [GOC:TermGenie]
synonym: "activation of transcription from mitochondrial promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of transcription from mitochondrial promoter" EXACT []
synonym: "up regulation of mitochondrial transcription" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:1903108 ! regulation of mitochondrial transcription
relationship: positively_regulates GO:0006390 ! mitochondrial transcription

[Term]
id: GO:1903110
name: regulation of single-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:1903516 ! regulation of single strand break repair
relationship: regulates GO:1990396 ! single-strand break repair via homologous recombination

[Term]
id: GO:1903111
name: negative regulation of single-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]
synonym: "down regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "downregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "inhibition of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie]
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination
is_a: GO:1903517 ! negative regulation of single strand break repair
relationship: negatively_regulates GO:1990396 ! single-strand break repair via homologous recombination

[Term]
id: GO:1903112
name: positive regulation of single-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]
synonym: "activation of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie]
synonym: "up regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "upregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination
is_a: GO:1903518 ! positive regulation of single strand break repair
relationship: positively_regulates GO:1990396 ! single-strand break repair via homologous recombination

[Term]
id: GO:1903113
name: copper ion transmembrane transporter complex
namespace: cellular_component
def: "A protein complex which is capable of copper ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23122209]
comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209 (inferred from direct assay).
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1903114
name: silver ion transmembrane transporter complex
namespace: cellular_component
def: "A protein complex which is capable of silver ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11283292]
comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:11283292 (inferred from direct assay).
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1903115
name: regulation of actin filament-based movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
is_a: GO:0032970 ! regulation of actin filament-based process
relationship: regulates GO:0030048 ! actin filament-based movement

[Term]
id: GO:1903116
name: positive regulation of actin filament-based movement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie]
synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903115 ! regulation of actin filament-based movement
relationship: positively_regulates GO:0030048 ! actin filament-based movement

[Term]
id: GO:1903117
name: obsolete regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of actin filament organization involved in cytokinetic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "regulation of actin filament organisation of constriction ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of constriction ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of constriction ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903118
name: obsolete urate homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of urate within an organism or cell." [GO_REF:0000072, GOC:dph, GOC:TermGenie, PMID:22306318]
comment: This term was obsoleted because this process does not exist: urea is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
is_obsolete: true
consider: GO:0003014

[Term]
id: GO:1903119
name: protein localization to actin cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie]
is_a: GO:0044380 ! protein localization to cytoskeleton

[Term]
id: GO:1903120
name: protein localization to actin filament bundle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization to actin cable" RELATED [GOC:mah]
is_a: GO:1903119 ! protein localization to actin cytoskeleton

[Term]
id: GO:1903121
name: regulation of TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors
relationship: regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway

[Term]
id: GO:1903122
name: negative regulation of TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "down regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902042 ! negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway
relationship: negatively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway

[Term]
id: GO:1903123
name: regulation of thioredoxin peroxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "regulation of TrxPx activity" EXACT [GOC:TermGenie]
is_a: GO:2000468 ! regulation of peroxidase activity

[Term]
id: GO:1903124
name: obsolete negative regulation of thioredoxin peroxidase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TrxPx activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TrxPx activity" EXACT [GOC:TermGenie]
synonym: "downregulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TrxPx activity" EXACT [GOC:TermGenie]
synonym: "inhibition of thiol peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of thioredoxin peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TPx activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TrxPx activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TrxPx activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903125
name: negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
namespace: biological_process
def: "A peptidyl-threonine phosphorylation that results in negative regulation of thioredoxin peroxidase activity." [GO_REF:0000063, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of thiol peroxidase activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TrxPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:1903126
name: negative regulation of centriole-centriole cohesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434]
synonym: "down regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "downregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "inhibition of centriole-centriole cohesion" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0030997 ! regulation of centriole-centriole cohesion
relationship: negatively_regulates GO:0010457 ! centriole-centriole cohesion

[Term]
id: GO:1903127
name: positive regulation of centriole-centriole cohesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434]
synonym: "activation of centriole-centriole cohesion" NARROW [GOC:TermGenie]
synonym: "up regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "upregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
is_a: GO:0030997 ! regulation of centriole-centriole cohesion
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0010457 ! centriole-centriole cohesion

[Term]
id: GO:1903131
name: mononuclear cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]
is_a: GO:0002521 ! leukocyte differentiation

[Term]
id: GO:1903132
name: regulation of tube lumen cavitation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0060605 ! tube lumen cavitation

[Term]
id: GO:1903133
name: negative regulation of tube lumen cavitation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778]
synonym: "inhibition of tube lumen cavitation" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903132 ! regulation of tube lumen cavitation
relationship: negatively_regulates GO:0060605 ! tube lumen cavitation

[Term]
id: GO:1903134
name: obsolete trehalose catabolic process involved in cellular response to stress
namespace: biological_process
def: "OBSOLETE. Any trehalose catabolic process that is involved in cellular response to stress." [GO_REF:0000060, GOC:TermGenie, PMID:15965643]
comment: This term was obsoleted because it does not represent a specific pathway.
synonym: "mycose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "mycose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "mykose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "mykose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "trehalose breakdown involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "trehalose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "trehalose degradation involved in cellular response to stress" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903135
name: cupric ion binding
namespace: molecular_function
def: "Binding to a cupric ion, copper(2+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]
synonym: "copper(2+)binding" EXACT [CHEBI:29036]
synonym: "Cu(2+) binding" EXACT [CHEBI:29036]
synonym: "Cu(II) binding" EXACT [PMID:24567322]
is_a: GO:0005507 ! copper ion binding

[Term]
id: GO:1903136
name: cuprous ion binding
namespace: molecular_function
def: "Binding to a cuprous ion, copper(1+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]
synonym: "copper(1+) binding" EXACT [CHEBI:49552]
synonym: "Cu(+) binding" EXACT [CHEBI:49552]
synonym: "Cu(I) binding" EXACT [PMID:24567322]
is_a: GO:0005507 ! copper ion binding

[Term]
id: GO:1903137
name: regulation of cell integrity MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cell integrity MAPK cascade." [GOC:vw]
synonym: "regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "regulation of cell wall integrity MAPK cascade" NARROW []
synonym: "regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT []
synonym: "regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "regulation of Slt2 cascade" NARROW [GOC:TermGenie]
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
relationship: regulates GO:0000196 ! cell integrity MAPK cascade

[Term]
id: GO:1903138
name: negative regulation of cell integrity MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cell integrity MAPK cascade." [GOC:vw]
synonym: "inhibition of cell wall biogenesis, MAPKKK cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell wall integrity MAPK cascade" NARROW []
synonym: "negative regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade
is_a: GO:1903137 ! regulation of cell integrity MAPK cascade
relationship: negatively_regulates GO:0000196 ! cell integrity MAPK cascade

[Term]
id: GO:1903139
name: positive regulation of cell integrity MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cell integrity MAPK cascade." [GOC:vw]
synonym: "activation of cell integrity MAPK pathway" NARROW [GOC:TermGenie]
synonym: "activation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "activation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "activation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell wal integrity MAPK pathway" EXACT []
synonym: "positive regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT []
synonym: "positive regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Slt2 cascade" NARROW [GOC:TermGenie]
is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade
is_a: GO:1903137 ! regulation of cell integrity MAPK cascade
relationship: positively_regulates GO:0000196 ! cell integrity MAPK cascade

[Term]
id: GO:1903140
name: regulation of establishment of endothelial barrier
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]
is_a: GO:1901550 ! regulation of endothelial cell development
relationship: regulates GO:0061028 ! establishment of endothelial barrier

[Term]
id: GO:1903141
name: negative regulation of establishment of endothelial barrier
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]
synonym: "down regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of endothelial barrier" NARROW [GOC:TermGenie]
is_a: GO:1901551 ! negative regulation of endothelial cell development
is_a: GO:1903140 ! regulation of establishment of endothelial barrier
relationship: negatively_regulates GO:0061028 ! establishment of endothelial barrier

[Term]
id: GO:1903142
name: positive regulation of establishment of endothelial barrier
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]
synonym: "activation of establishment of endothelial barrier" NARROW [GOC:TermGenie]
synonym: "up regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
is_a: GO:1901552 ! positive regulation of endothelial cell development
is_a: GO:1903140 ! regulation of establishment of endothelial barrier
relationship: positively_regulates GO:0061028 ! establishment of endothelial barrier

[Term]
id: GO:1903143
name: adrenomedullin receptor complex
namespace: cellular_component
def: "A transmembrane, G protein-coupled signaling receptor complex which is capable of adrenomedullin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22102369]
comment: An example of this is RAMP2 in human (O60895) in PMID:22102369 (inferred from direct assay).
synonym: "adrenomedullin receptor AM1 complex" NARROW []
synonym: "adrenomedullin receptor AM2 complex" NARROW []
is_a: GO:0038037 ! G protein-coupled receptor dimeric complex
is_a: GO:1903439 ! calcitonin family receptor complex

[Term]
id: GO:1903144
name: actomyosin contractile ring actin filament
namespace: cellular_component
def: "Any actin filament that is part of a actomyosin contractile ring." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052]
synonym: "actin filament of actomyosin contractile ring" EXACT [GOC:TermGenie]
synonym: "actin filament of actomyosin ring" EXACT [GOC:TermGenie]
synonym: "actin filament of CAR" EXACT [GOC:TermGenie]
synonym: "actin filament of contractile actomyosin ring" EXACT [GOC:TermGenie]
synonym: "actin filament of cytokinetic ring" EXACT [GOC:TermGenie]
is_a: GO:0005884 ! actin filament
relationship: part_of GO:0005826 ! actomyosin contractile ring

[Term]
id: GO:1903145
name: actin filament of cell cortex of cell tip
namespace: cellular_component
def: "Any actin filament that is part of a cell cortex of cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052]
synonym: "actin filament of cell cortex of cell end" EXACT [GOC:TermGenie]
synonym: "microfilament of cell cortex of cell end" EXACT [GOC:TermGenie]
synonym: "microfilament of cell cortex of cell tip" EXACT [GOC:TermGenie]
is_a: GO:0005884 ! actin filament
relationship: part_of GO:0051285 ! cell cortex of cell tip

[Term]
id: GO:1903146
name: regulation of autophagy of mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]
synonym: "regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
is_a: GO:0010506 ! regulation of autophagy
relationship: regulates GO:0000422 ! autophagy of mitochondrion

[Term]
id: GO:1903147
name: negative regulation of autophagy of mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]
synonym: "down regulation of mitochondrial degradation" BROAD [GOC:TermGenie]
synonym: "down regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "down-regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "down-regulation of mitophagy" BROAD [GOC:TermGenie]
synonym: "downregulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "inhibition of mitochondrion degradation" RELATED [GOC:TermGenie]
synonym: "inhibition of mitophagy" NARROW [GOC:TermGenie]
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:1903146 ! regulation of autophagy of mitochondrion
relationship: negatively_regulates GO:0000422 ! autophagy of mitochondrion

[Term]
id: GO:1903148
name: obsolete uracil transmembrane transporter activity involved in uracil import into cell
namespace: molecular_function
def: "OBSOLETE. Any uracil transmembrane transporter activity that is involved in uracil import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "uracil transmembrane transporter activity involved in uracil import into cell" EXACT []
synonym: "uracil/uridine permease activity involved in uracil import into cell" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903149
name: obsolete adenine transmembrane transporter activity involved in adenine import into cell
namespace: molecular_function
def: "OBSOLETE. Any adenine transmembrane transporter activity that is involved in adenine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "adenine transmembrane transporter activity involved in adenine import into cell" EXACT []
is_obsolete: true

[Term]
id: GO:1903150
name: obsolete calcium ion transmembrane transporter activity involved in calcium ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any calcium ion transmembrane transporter activity that is involved in calcium ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "calcium ion transmembrane transporter activity involved in calcium ion import into cell" EXACT []
synonym: "calcium ion transmembrane transporter activity involved in calcium ion uptake into cell" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903151
name: obsolete carbohydrate transmembrane transporter activity involved in carbohydrate import into cell
namespace: molecular_function
def: "OBSOLETE. Any carbohydrate transmembrane transporter activity that is involved in carbohydrate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "carbohydrate transmembrane transporter activity involved in carbohydrate import into cell" EXACT []
synonym: "sugar transporter involved in carbohydrate import into cell" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903152
name: obsolete copper ion transmembrane transporter activity involved in copper ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any copper ion transmembrane transporter activity that is involved in copper ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "copper ion transmembrane transporter activity involved in copper cation import into cell" EXACT [GOC:TermGenie]
synonym: "copper ion transmembrane transporter activity involved in copper ion import into cell" EXACT []
synonym: "intracellular copper ion transporter involved in copper cation import into cell" NARROW [GOC:TermGenie]
synonym: "intracellular copper ion transporter involved in copper ion import into cell" NARROW [GOC:TermGenie]
synonym: "plasma membrane copper transporter involved in copper cation import into cell" NARROW [GOC:TermGenie]
synonym: "plasma membrane copper transporter involved in copper ion import into cell" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903153
name: obsolete ferrous iron transmembrane transporter activity involved in ferrous iron import into cell
namespace: molecular_function
def: "OBSOLETE. Any ferrous iron transmembrane transporter activity that is involved in ferrous iron import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "ferrous iron transmembrane transporter activity involved in ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "ferrous iron transmembrane transporter activity involved in ferrous iron import into cell" EXACT []
is_obsolete: true

[Term]
id: GO:1903154
name: obsolete glucose transmembrane transporter activity involved in glucose import into cell
namespace: molecular_function
def: "OBSOLETE. Any glucose transmembrane transporter activity that is involved in glucose import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "galactose/glucose (methylgalactoside) porter activity involved in glucose import into cell" RELATED [GOC:TermGenie]
synonym: "glucose permease activity involved in glucose import into cell" EXACT [GOC:TermGenie]
synonym: "glucose transmembrane transporter activity involved in glucose import into cell" EXACT []
synonym: "lactose/glucose efflux transporter activity involved in glucose import into cell" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903155
name: obsolete glutathione transmembrane transporter activity involved in glutathione import into cell
namespace: molecular_function
def: "OBSOLETE. Any glutathione transmembrane transporter activity that is involved in glutathione import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "glutathione transmembrane transporter activity involved in glutathione import into cell" EXACT []
synonym: "glutathione transmembrane transporter activity involved in glutathione uptake" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903156
name: obsolete guanine transmembrane transporter activity involved in guanine import into cell
namespace: molecular_function
def: "OBSOLETE. Any guanine transmembrane transporter activity that is involved in guanine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "guanine transmembrane transporter activity involved in guanine import into cell" EXACT []
is_obsolete: true

[Term]
id: GO:1903157
name: obsolete iron ion transmembrane transporter activity involved in iron ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any iron ion transmembrane transporter activity that is involved in iron ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "iron ion transmembrane transporter activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "iron ion transmembrane transporter activity involved in iron ion import into cell" EXACT []
synonym: "iron transporter activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "iron transporter activity involved in iron ion import into cell" EXACT [GOC:TermGenie]
synonym: "multicopper ferroxidase iron transport mediator activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "multicopper ferroxidase iron transport mediator activity involved in iron ion import into cell" RELATED [GOC:TermGenie]
synonym: "transmembrane iron ion permease activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "transmembrane iron ion permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie]
synonym: "transmembrane iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "transmembrane iron permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie]
synonym: "zinc, iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "zinc, iron permease activity involved in iron ion import into cell" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903158
name: obsolete L-glutamate transmembrane transporter activity involved in L-glutamate import into cell
namespace: molecular_function
def: "OBSOLETE. Any L-glutamate transmembrane transporter activity that is involved in L-glutamate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "glutamate/aspartate porter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie]
synonym: "glutamate/aspartate:sodium symporter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie]
synonym: "L-glutamate transmembrane transporter activity involved in L-glutamate import into cell" EXACT []
is_obsolete: true

[Term]
id: GO:1903159
name: obsolete malate transmembrane transporter activity involved in malate import into cell
namespace: molecular_function
def: "OBSOLETE. Any malate transmembrane transporter activity that is involved in malate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in malate import into cell" RELATED [GOC:TermGenie]
synonym: "malate transmembrane transporter activity involved in malate import into cell" EXACT []
is_obsolete: true

[Term]
id: GO:1903160
name: obsolete nickel cation transmembrane transporter activity involved in nickel cation import into cell
namespace: molecular_function
def: "OBSOLETE. Any nickel cation transmembrane transporter activity that is involved in nickel cation import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "nickel cation transmembrane transporter activity involved in nickel cation import into cell" EXACT []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity involved in nickel cation import into cell" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903161
name: obsolete pantothenate transmembrane transporter activity involved in pantothenate import into cell
namespace: molecular_function
def: "OBSOLETE. Any pantothenate transmembrane transporter activity that is involved in pantothenate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "pantothenate transmembrane transporter activity involved in pantothenate import into cell" EXACT []
synonym: "vitamin B5 transmembrane transporter activity involved in pantothenate import into cell" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903162
name: obsolete serine transmembrane transporter activity involved in serine import into cell
namespace: molecular_function
def: "OBSOLETE. Any serine transmembrane transporter activity that is involved in serine import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "serine transmembrane transporter activity involved in serine import into cell" EXACT []
is_obsolete: true

[Term]
id: GO:1903163
name: obsolete sodium ion transmembrane transporter activity involved in sodium ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any sodium ion transmembrane transporter activity that is involved in sodium ion import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "sodium ion transmembrane transporter activity involved in sodium ion import into cell" EXACT []
synonym: "sodium transporter activity involved in sodium ion import into cell" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903164
name: obsolete succinate transmembrane transporter activity involved in succinate import into cell
namespace: molecular_function
def: "OBSOLETE. Any succinate transmembrane transporter activity that is involved in succinate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in succinate import into cell" RELATED [GOC:TermGenie]
synonym: "succinate transmembrane transporter activity involved in succinate import into cell" EXACT []
is_obsolete: true

[Term]
id: GO:1903165
name: response to polycyclic arene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1903166
name: cellular response to polycyclic arene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1903165 ! response to polycyclic arene

[Term]
id: GO:1903167
name: regulation of pyrroline-5-carboxylate reductase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of P5CR activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1903168
name: positive regulation of pyrroline-5-carboxylate reductase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23743200]
subset: gocheck_obsoletion_candidate
synonym: "activation of 1-pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-proline oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-proline-NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-proline:NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of P5CR activity" NARROW [GOC:TermGenie]
synonym: "activation of pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1903167 ! regulation of pyrroline-5-carboxylate reductase activity

[Term]
id: GO:1903169
name: regulation of calcium ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]
comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol
synonym: "regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
is_a: GO:0051924 ! regulation of calcium ion transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: regulates GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:1903170
name: negative regulation of calcium ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]
comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol
synonym: "down regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of transmembrane calcium transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "negative regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
relationship: negatively_regulates GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:1903171
name: obsolete carbon dioxide homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of carbon dioxide within an organism or cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594]
comment: The reason for obsoletion is that there is no evidence that this process exists.
is_obsolete: true
replaced_by: GO:0160061

[Term]
id: GO:1903172
name: obsolete cellular carbon dioxide homeostasis
namespace: biological_process
def: "OBSOLETE. Any biological process involved in the maintenance of an internal steady state of carbon dioxide at the level of the cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594]
comment: The reason for obsoletion is that there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1903173
name: fatty alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]
synonym: "fatty alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:1903174
name: fatty alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]
synonym: "fatty alcohol breakdown" EXACT [GOC:TermGenie]
synonym: "fatty alcohol catabolism" EXACT [GOC:TermGenie]
synonym: "fatty alcohol degradation" EXACT [GOC:TermGenie]
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:1903175
name: fatty alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]
synonym: "fatty alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "fatty alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "fatty alcohol formation" EXACT [GOC:TermGenie]
synonym: "fatty alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:1903176
name: regulation of tyrosine 3-monooxygenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:1903177
name: obsolete negative regulation of tyrosine 3-monooxygenase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903178
name: positive regulation of tyrosine 3-monooxygenase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]
subset: gocheck_obsoletion_candidate
synonym: "activation of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of TH activity" EXACT [PMID:19703902]
synonym: "positive regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "stimulation of TH activity" EXACT [PMID:19703902]
synonym: "up regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity

[Term]
id: GO:1903179
name: regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0042053 ! regulation of dopamine metabolic process
relationship: regulates GO:0042416 ! dopamine biosynthetic process

[Term]
id: GO:1903180
name: negative regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dopamine anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine formation" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045963 ! negative regulation of dopamine metabolic process
is_a: GO:1903179 ! regulation of dopamine biosynthetic process
relationship: negatively_regulates GO:0042416 ! dopamine biosynthetic process

[Term]
id: GO:1903181
name: positive regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]
synonym: "activation of dopamine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of dopamine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of dopamine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of dopamine formation" NARROW [GOC:TermGenie]
synonym: "activation of dopamine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045964 ! positive regulation of dopamine metabolic process
is_a: GO:1903179 ! regulation of dopamine biosynthetic process
relationship: positively_regulates GO:0042416 ! dopamine biosynthetic process

[Term]
id: GO:1903182
name: regulation of SUMO transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
is_a: GO:0033233 ! regulation of protein sumoylation
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1903183
name: obsolete negative regulation of SUMO transferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "down regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of SUMO ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "down-regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of SUMO ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "downregulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of SUMO ligase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of SMT3 conjugating enzyme" NARROW [GOC:TermGenie]
synonym: "inhibition of SUMO conjugating enzyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of SUMO ligase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "negative regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903184
name: L-dopa metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146]
synonym: "L-dopa metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:1903185
name: L-dopa biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146]
synonym: "L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "L-dopa formation" EXACT [GOC:TermGenie]
synonym: "L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0042398 ! modified amino acid biosynthetic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1903184 ! L-dopa metabolic process

[Term]
id: GO:1903186
name: regulation of vitellogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]
synonym: "regulation of yolk production" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007296 ! vitellogenesis

[Term]
id: GO:1903187
name: negative regulation of vitellogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]
synonym: "down regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "down-regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "downregulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of yolk production" EXACT [GOC:TermGenie]
synonym: "inhibition of vitellogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of yolk production" NARROW [GOC:TermGenie]
synonym: "negative regulation of yolk production" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903186 ! regulation of vitellogenesis
relationship: negatively_regulates GO:0007296 ! vitellogenesis

[Term]
id: GO:1903188
name: positive regulation of vitellogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]
synonym: "activation of vitellogenesis" NARROW [GOC:TermGenie]
synonym: "activation of yolk production" NARROW [GOC:TermGenie]
synonym: "positive regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "up regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "upregulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of yolk production" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903186 ! regulation of vitellogenesis
relationship: positively_regulates GO:0007296 ! vitellogenesis

[Term]
id: GO:1903189
name: glyoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "glyoxal metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006081 ! aldehyde metabolic process

[Term]
id: GO:1903190
name: glyoxal catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22523093, PMID:23651081]
synonym: "glyoxal breakdown" EXACT [GOC:TermGenie]
synonym: "glyoxal catabolism" EXACT [GOC:TermGenie]
synonym: "glyoxal degradation" EXACT [GOC:TermGenie]
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:1903189 ! glyoxal metabolic process

[Term]
id: GO:1903191
name: glyoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "glyoxal anabolism" EXACT [GOC:TermGenie]
synonym: "glyoxal biosynthesis" EXACT [GOC:TermGenie]
synonym: "glyoxal formation" EXACT [GOC:TermGenie]
synonym: "glyoxal synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:1903189 ! glyoxal metabolic process

[Term]
id: GO:1903192
name: sesquarterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333]
synonym: "sesquarterpene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:1903193
name: sesquarterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333]
synonym: "sesquarterpene anabolism" EXACT [GOC:TermGenie]
synonym: "sesquarterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "sesquarterpene formation" EXACT [GOC:TermGenie]
synonym: "sesquarterpene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1903192 ! sesquarterpene metabolic process

[Term]
id: GO:1903195
name: regulation of L-dopa biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:1903185 ! L-dopa biosynthetic process

[Term]
id: GO:1903196
name: negative regulation of L-dopa biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of L-dopa anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa formation" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1903195 ! regulation of L-dopa biosynthetic process
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:1903185 ! L-dopa biosynthetic process

[Term]
id: GO:1903197
name: positive regulation of L-dopa biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528]
synonym: "activation of L-dopa anabolism" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa formation" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1903195 ! regulation of L-dopa biosynthetic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
relationship: positively_regulates GO:1903185 ! L-dopa biosynthetic process

[Term]
id: GO:1903198
name: regulation of L-dopa decarboxylase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:1903199
name: obsolete negative regulation of L-dopa decarboxylase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DDC activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DOPA decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903200
name: positive regulation of L-dopa decarboxylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]
subset: gocheck_obsoletion_candidate
synonym: "activation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of DDC activity" NARROW [GOC:TermGenie]
synonym: "activation of DOPA decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051349 ! positive regulation of lyase activity
is_a: GO:1903198 ! regulation of L-dopa decarboxylase activity

[Term]
id: GO:1903201
name: obsolete regulation of oxidative stress-induced cell death
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "regulation of cell death in response to oxidative stress" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:1903202
name: obsolete negative regulation of oxidative stress-induced cell death
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "down regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell death in response to oxidative stress" EXACT [GOC:bf]
synonym: "protection against oxidative stress-induced cell death" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:1903203
name: obsolete regulation of oxidative stress-induced neuron death
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "regulation of neuron death in response to oxidative stress" EXACT [GOC:bf]
synonym: "regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903204
name: obsolete negative regulation of oxidative stress-induced neuron death
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "down regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "inhibition of neuron death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidative stress-induced neuron death" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "neuronal protection under oxidative stress" RELATED [GOC:bf]
synonym: "neuroprotection against oxidative stress" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:1903205
name: obsolete regulation of hydrogen peroxide-induced cell death
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "protection against hydrogen peroxide-mediated cell death" RELATED [GOC:bf]
synonym: "regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903206
name: obsolete negative regulation of hydrogen peroxide-induced cell death
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804]
comment: The reason for obsoletion is that this represents a phenotype or an assay.
synonym: "down regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "downregulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "inhibition of cell death in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "negative regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "protection against H2O2-induced cell death" RELATED [GOC:bf]
synonym: "protection against hydrogen peroxide-induced cell death" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:1903207
name: obsolete regulation of hydrogen peroxide-induced neuron death
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903208
name: obsolete negative regulation of hydrogen peroxide-induced neuron death
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "down regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-induced neuron death" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron death in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron death in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "negative regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "neuroprotection against H2O2-induced cell death" RELATED [GOC:bf]
synonym: "neuroprotection against hydrogen peroxide" RELATED [GOC:bf]
synonym: "protection against H2O2-induced neuron death" RELATED [GOC:bf]
synonym: "protection against hydrogen peroxide-induced neuron death" RELATED [GOC:bf]
is_obsolete: true

[Term]
id: GO:1903209
name: obsolete positive regulation of oxidative stress-induced cell death
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20969476]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "activation of cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "enhancement of oxidative stress-induced cell death" NARROW []
synonym: "positive regulation of cell death in response to oxidative stress" EXACT []
synonym: "up regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903210
name: podocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a glomerular visceral epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:23515840]
synonym: "glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "glomerular visceral epithelial cell apoptotic process" EXACT []
synonym: "podocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1903212
name: protein localization to mating-type region heterochromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:18761674]
synonym: "protein localisation in mating-type region heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to mating-type region heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localization in mating-type region heterochromatin" EXACT [GOC:TermGenie]
is_a: GO:0097355 ! protein localization to heterochromatin

[Term]
id: GO:1903213
name: protein localization to subtelomeric heterochromatin
namespace: biological_process
alt_id: GO:1990152
def: "A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:21300781, SO:0001997]
synonym: "protein localisation in subtelomeric heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to subtelomeric heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to telomeric heterochromatin" RELATED [GOC:mah]
synonym: "protein localization in subtelomeric heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localization to telomeric heterochromatin" RELATED []
is_a: GO:0070198 ! protein localization to chromosome, telomeric region
is_a: GO:0097355 ! protein localization to heterochromatin

[Term]
id: GO:1903214
name: regulation of protein targeting to mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
is_a: GO:1903533 ! regulation of protein targeting
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
relationship: regulates GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:1903215
name: negative regulation of protein targeting to mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]
synonym: "down regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "down regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "down regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "down regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "downregulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "downregulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "inhibition of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "inhibition of protein import into mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of protein targeting to mitochondria" NARROW [GOC:TermGenie]
synonym: "inhibition of protein targeting to mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-mitochondrial targeting" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
is_a: GO:1903214 ! regulation of protein targeting to mitochondrion
is_a: GO:1903748 ! negative regulation of establishment of protein localization to mitochondrion
relationship: negatively_regulates GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:1903216
name: regulation of protein processing involved in protein targeting to mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]
synonym: "regulation of mitochondrial processing" BROAD [GOC:TermGenie]
synonym: "regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
is_a: GO:0070613 ! regulation of protein processing
relationship: regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion

[Term]
id: GO:1903217
name: negative regulation of protein processing involved in protein targeting to mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]
synonym: "down regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "down regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "downregulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "inhibition of protein processing involved in protein targeting to mitochondrion" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:1903216 ! regulation of protein processing involved in protein targeting to mitochondrion
relationship: negatively_regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion

[Term]
id: GO:1903218
name: regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1903219
name: obsolete negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "down regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "down regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "down regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "down-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "downregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie]
synonym: "inhibition of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of NADP-malic enzyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "negative regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903220
name: obsolete positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "activation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie]
synonym: "activation of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie]
synonym: "activation of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie]
synonym: "activation of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie]
synonym: "activation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "activation of NADP-malic enzyme activity" NARROW [GOC:TermGenie]
synonym: "activation of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "positive regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "up regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "up-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "upregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903221
name: regulation of mitotic recombination-dependent replication fork processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences." [GO_REF:0000058, GOC:TermGenie, PMID:23093942]
synonym: "prevention of genomic instability induced by DNA replication fork arrest" RELATED [PMID:23093942]
synonym: "regulation of mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in replication fork processing" EXACT []
synonym: "regulation of mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in replication restart" RELATED [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:1990426 ! mitotic recombination-dependent replication fork processing

[Term]
id: GO:1903222
name: quinolinic acid transmembrane transport
namespace: biological_process
def: "The process in which quinolinic acid is transported across a membrane." [GO_REF:0000069, GOC:di, GOC:TermGenie, PMID:23457190]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1903223
name: obsolete positive regulation of oxidative stress-induced neuron death
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23858059]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "activation of neuron death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "activation of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "activation of oxidative stress-induced neuron death" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuron death in response to oxidative stress" EXACT [GOC:bf]
synonym: "positive regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "sensitization of neuron to oxidative stress-induced cell death" RELATED [PMID:23858059]
synonym: "up regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903224
name: regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0035987 ! endodermal cell differentiation

[Term]
id: GO:1903225
name: negative regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
relationship: negatively_regulates GO:0035987 ! endodermal cell differentiation

[Term]
id: GO:1903226
name: positive regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
relationship: positively_regulates GO:0035987 ! endodermal cell differentiation

[Term]
id: GO:1903227
name: xanthosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]
synonym: "xanthosine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:1903228
name: xanthosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]
synonym: "xanthosine breakdown" EXACT [GOC:TermGenie]
synonym: "xanthosine catabolism" EXACT [GOC:TermGenie]
synonym: "xanthosine degradation" EXACT [GOC:TermGenie]
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:1903227 ! xanthosine metabolic process

[Term]
id: GO:1903229
name: xanthosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]
synonym: "xanthosine anabolism" EXACT [GOC:TermGenie]
synonym: "xanthosine biosynthesis" EXACT [GOC:TermGenie]
synonym: "xanthosine formation" EXACT [GOC:TermGenie]
synonym: "xanthosine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:1903227 ! xanthosine metabolic process

[Term]
id: GO:1903230
name: obsolete miRNA binding involved in posttranscriptional gene silencing
namespace: molecular_function
def: "OBSOLETE. Any miRNA binding that is involved in posttranscriptional gene silencing." [GO_REF:0000061, GOC:BHF, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "microRNA binding involved in cosuppression" RELATED [GOC:TermGenie]
synonym: "microRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "microRNA binding involved in posttranscriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "microRNA binding involved in PTGS" EXACT [GOC:TermGenie]
synonym: "microRNA binding involved in quelling" EXACT [GOC:TermGenie]
synonym: "miRNA binding involved in cosuppression" RELATED [GOC:TermGenie]
synonym: "miRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "miRNA binding involved in posttranscriptional gene silencing" EXACT []
synonym: "miRNA binding involved in PTGS" EXACT [GOC:TermGenie]
synonym: "miRNA binding involved in quelling" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903231
name: mRNA base-pairing translational repressor activity
namespace: molecular_function
alt_id: GO:0150100
def: "A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing." [GOC:BHF, GOC:BHF_miRNA, PMID:18197166, PMID:20533884]
comment: This term is intended for microRNAs that act by base-pairing with a target mRNA.
synonym: "mRNA base-pairing post-transcriptional repressor activity" RELATED []
synonym: "mRNA base-pairing posttranscriptional repressor activity" EXACT []
synonym: "mRNA binding involved in cosuppression" RELATED [GOC:TermGenie]
synonym: "mRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "mRNA binding involved in posttranscriptional gene silencing" EXACT []
synonym: "mRNA binding involved in PTGS" EXACT [GOC:TermGenie]
synonym: "mRNA binding involved in quelling" EXACT [GOC:TermGenie]
synonym: "mRNA binding translation repressor activity" BROAD []
synonym: "RNA binding involved in cosuppression" BROAD []
synonym: "RNA binding involved in post-transcriptional gene silencing" BROAD []
synonym: "RNA binding involved in posttranscriptional gene silencing" BROAD []
synonym: "RNA binding involved in PTGS" BROAD []
synonym: "RNA binding involved in quelling" BROAD []
synonym: "translational inhibitor activity via mRNA base-pairing" EXACT []
is_a: GO:0003729 ! mRNA binding
is_a: GO:0030371 ! translation repressor activity

[Term]
id: GO:1903232
name: melanosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774]
synonym: "melanosome formation" EXACT [GOC:TermGenie]
is_a: GO:0032438 ! melanosome organization
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:1903233
name: regulation of calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP)
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
relationship: regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter

[Term]
id: GO:1903234
name: negative regulation of calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP)
synonym: "down regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie]
is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis
is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter
is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis
relationship: negatively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter

[Term]
id: GO:1903235
name: positive regulation of calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP)
synonym: "activation of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter
is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis
relationship: positively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter

[Term]
id: GO:1903236
name: regulation of leukocyte tethering or rolling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
relationship: regulates GO:0050901 ! leukocyte tethering or rolling

[Term]
id: GO:1903237
name: negative regulation of leukocyte tethering or rolling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]
synonym: "down regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte tethering or rolling" NARROW [GOC:TermGenie]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:1903236 ! regulation of leukocyte tethering or rolling
is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell
relationship: negatively_regulates GO:0050901 ! leukocyte tethering or rolling

[Term]
id: GO:1903238
name: positive regulation of leukocyte tethering or rolling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]
synonym: "activation of leukocyte tethering or rolling" NARROW [GOC:TermGenie]
synonym: "up regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
is_a: GO:1903236 ! regulation of leukocyte tethering or rolling
is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell
relationship: positively_regulates GO:0050901 ! leukocyte tethering or rolling

[Term]
id: GO:1903239
name: obsolete regulation of positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of positive regulation of the force of heart contraction by chemical signal" EXACT []
synonym: "regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903240
name: obsolete negative regulation of positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "down regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "downregulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "downregulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "inhibition of positive regulation of the force of heart contraction by chemical signal" NARROW [GOC:TermGenie]
synonym: "inhibition of positive regulation of the force of heart muscle contraction by chemical signal" NARROW [GOC:TermGenie]
synonym: "negative regulation of positive regulation of the force of heart contraction by chemical signal" EXACT []
synonym: "negative regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903241
name: U2-type prespliceosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome." [GO_REF:0000079, GOC:TermGenie, PMID:12374752]
synonym: "GT-AG prespliceosome assembly" NARROW [GOC:TermGenie]
synonym: "GT-AG prespliceosome formation" NARROW [GOC:TermGenie]
synonym: "major prespliceosome assembly" EXACT [GOC:TermGenie]
synonym: "major prespliceosome formation" EXACT [GOC:TermGenie]
synonym: "mammalian U2-type spliceosomal complex A assembly" NARROW [GOC:TermGenie]
synonym: "mammalian U2-type spliceosomal complex A formation" NARROW [GOC:TermGenie]
synonym: "U2-type prespliceosome formation" EXACT [GOC:TermGenie]
synonym: "yeast U2-type spliceosomal complex B assembly" NARROW [GOC:TermGenie]
synonym: "yeast U2-type spliceosomal complex B formation" NARROW [GOC:TermGenie]
is_a: GO:0000245 ! spliceosomal complex assembly

[Term]
id: GO:1903242
name: regulation of cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress

[Term]
id: GO:1903243
name: negative regulation of cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]
synonym: "down regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie]
is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy
is_a: GO:0010616 ! negative regulation of cardiac muscle adaptation
is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress
relationship: negatively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress

[Term]
id: GO:1903244
name: positive regulation of cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]
synonym: "activation of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy
is_a: GO:0010615 ! positive regulation of cardiac muscle adaptation
is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress
relationship: positively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress

[Term]
id: GO:1903245
name: obsolete regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280]
comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation.
synonym: "regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903246
name: obsolete negative regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280]
comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation.
synonym: "down regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "down regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "down-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "downregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "downregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "downregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "negative regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "negative regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903247
name: obsolete positive regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280]
comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation.
synonym: "activation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "positive regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "positive regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "up regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "up-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "upregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "upregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "upregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903248
name: regulation of citrulline biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]
synonym: "regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "regulation of citrulline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0019240 ! citrulline biosynthetic process

[Term]
id: GO:1903249
name: negative regulation of citrulline biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]
synonym: "down regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of citrulline anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline formation" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrulline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1903248 ! regulation of citrulline biosynthetic process
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:0019240 ! citrulline biosynthetic process

[Term]
id: GO:1903250
name: positive regulation of citrulline biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]
synonym: "activation of citrulline anabolism" NARROW [GOC:TermGenie]
synonym: "activation of citrulline biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of citrulline biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of citrulline formation" NARROW [GOC:TermGenie]
synonym: "activation of citrulline synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1903248 ! regulation of citrulline biosynthetic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
relationship: positively_regulates GO:0019240 ! citrulline biosynthetic process

[Term]
id: GO:1903251
name: multi-ciliated epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224]
synonym: "multiciliate cell differentiation" BROAD []
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:1903252
name: obsolete hercynylcysteine sulfoxide metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
comment: This term was obsoleted because there is no evidence that this process exists. Hercynylcysteine is an intermediate in the ergothioneine and selenoneine biosynthetic pathway, not a final product.
synonym: "hercynylcysteine sulfoxide metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903253
name: obsolete hercynylcysteine sulfoxide biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
comment: This term was obsoleted because there is no evidence that this process exists. Hercynylcysteine is an intermediate in the ergothioneine and selenoneine biosynthetic pathway, not a final product.
synonym: "hercynylcysteine sulfoxide anabolism" EXACT [GOC:TermGenie]
synonym: "hercynylcysteine sulfoxide biosynthesis" EXACT [GOC:TermGenie]
synonym: "hercynylcysteine sulfoxide formation" EXACT [GOC:TermGenie]
synonym: "hercynylcysteine sulfoxide synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903254
name: obsolete hercynylselenocysteine metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
comment: This term was obsoleted because there is no evidence that this process exists. The corresponding activities, hercynylselenocysteine synthase ; GO:0044876 and  hercynylselenocysteine lyase activity ; GO:1990412, have been obsoleted.
synonym: "hercynylselenocysteine metabolism" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903255
name: obsolete hercynylselenocysteine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
comment: This term was obsoleted because there is no evidence that this process exists. The corresponding activities, hercynylselenocysteine synthase ; GO:0044876 and hercynylselenocysteine lyase activity ; GO:1990412, have been obsoleted.
synonym: "hercynylselenocysteine anabolism" EXACT [GOC:TermGenie]
synonym: "hercynylselenocysteine biosynthesis" EXACT [GOC:TermGenie]
synonym: "hercynylselenocysteine formation" EXACT [GOC:TermGenie]
synonym: "hercynylselenocysteine synthesis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903256
name: selenoneine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "L-selenoneine metabolic process" NARROW []
synonym: "selenoneine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0052701 ! modified histidine metabolic process

[Term]
id: GO:1903257
name: selenoneine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "L-selenoneine biosynthetic process" NARROW []
synonym: "selenoneine anabolism" EXACT [GOC:TermGenie]
synonym: "selenoneine biosynthesis" EXACT [GOC:TermGenie]
synonym: "selenoneine formation" EXACT [GOC:TermGenie]
synonym: "selenoneine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0052703 ! modified histidine biosynthetic process
is_a: GO:1903256 ! selenoneine metabolic process

[Term]
id: GO:1903258
name: sorbose import across plasma membrane
namespace: biological_process
def: "The process in which sorbose is transported from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:2878925]
synonym: "sorbose import into cell" EXACT []
is_a: GO:0140271 ! hexose import across plasma membrane

[Term]
id: GO:1903259
name: exon-exon junction complex disassembly
namespace: biological_process
def: "The disaggregation of an exon-exon junction complex into its constituent components." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:24967911]
synonym: "EJC disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:1903260
name: protein localization to mating projection tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mating projection tip." [GO_REF:0000087, GOC:TermGenie, PMID:11952834]
synonym: "protein localisation in mating projection tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to mating projection tip" EXACT [GOC:TermGenie]
synonym: "protein localization in mating projection tip" EXACT [GOC:TermGenie]
synonym: "protein localization to conjugation tube tip" NARROW []
synonym: "protein localization to shmoo tip" NARROW []
is_a: GO:1990151 ! protein localization to cell tip

[Term]
id: GO:1903264
name: obsolete nitrate reductase activity involved in anaerobic electron transport chain
namespace: molecular_function
def: "OBSOLETE. Any nitrate reductase activity that is involved in anaerobic electron transport chain." [GO_REF:0000061, GOC:dos, GOC:TermGenie, PMID:12910261]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "nitrate reductase (acceptor) involved in anaerobic electron transport chain" EXACT [GOC:TermGenie]
synonym: "nitrite:(acceptor) oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie]
synonym: "nitrite:acceptor oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie]
synonym: "respiratory nitrate reductase activity involved in anaerobic electron transport chain" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0008940

[Term]
id: GO:1903265
name: positive regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]
synonym: "activation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway
relationship: positively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:1903266
name: regulation of ornithine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]
comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay).
synonym: "regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ornithine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0090368 ! regulation of ornithine metabolic process
relationship: regulates GO:0006593 ! ornithine catabolic process

[Term]
id: GO:1903267
name: negative regulation of ornithine catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]
comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay).
synonym: "down regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of ornithine breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of ornithine catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ornithine catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ornithine degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ornithine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1903266 ! regulation of ornithine catabolic process
relationship: negatively_regulates GO:0006593 ! ornithine catabolic process

[Term]
id: GO:1903268
name: positive regulation of ornithine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]
synonym: "activation of ornithine breakdown" NARROW [GOC:TermGenie]
synonym: "activation of ornithine catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ornithine catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ornithine degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1903266 ! regulation of ornithine catabolic process
relationship: positively_regulates GO:0006593 ! ornithine catabolic process

[Term]
id: GO:1903269
name: ornithine carbamoyltransferase inhibitor complex
namespace: cellular_component
def: "A protein complex which is capable of ornithine carbamoyltransferase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12679340]
comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay).
synonym: "ornithine carbamoyltransferase arginase complex" NARROW []
synonym: "OTC-ARGI complex" NARROW []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1903270
name: regulation of cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804]
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
relationship: regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches

[Term]
id: GO:1903271
name: negative regulation of cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804]
synonym: "down regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie]
is_a: GO:1900248 ! negative regulation of cytoplasmic translational elongation
is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches
relationship: negatively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches

[Term]
id: GO:1903272
name: positive regulation of cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804]
synonym: "activation of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
is_a: GO:1900249 ! positive regulation of cytoplasmic translational elongation
is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches
relationship: positively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches

[Term]
id: GO:1903276
name: regulation of sodium ion export across plasma membrane
namespace: biological_process
alt_id: GO:1903273
def: "Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "regulation of sodium export" RELATED [GOC:TermGenie]
synonym: "regulation of sodium ion export" RELATED []
synonym: "regulation of sodium ion export from cell" EXACT []
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
relationship: regulates GO:0036376 ! sodium ion export across plasma membrane

[Term]
id: GO:1903277
name: negative regulation of sodium ion export across plasma membrane
namespace: biological_process
alt_id: GO:1903274
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "down regulation of sodium export" RELATED [GOC:TermGenie]
synonym: "down regulation of sodium ion export" RELATED [GOC:TermGenie]
synonym: "down regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium export" RELATED [GOC:TermGenie]
synonym: "down-regulation of sodium ion export" RELATED [GOC:TermGenie]
synonym: "down-regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium export" RELATED [GOC:TermGenie]
synonym: "downregulation of sodium ion export" RELATED [GOC:TermGenie]
synonym: "downregulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium export" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium ion export" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium ion export from cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of sodium export" RELATED [GOC:TermGenie]
synonym: "negative regulation of sodium ion export" RELATED []
synonym: "negative regulation of sodium ion export from cell" EXACT []
is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport
is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane
relationship: negatively_regulates GO:0036376 ! sodium ion export across plasma membrane

[Term]
id: GO:1903278
name: positive regulation of sodium ion export across plasma membrane
namespace: biological_process
alt_id: GO:1903275
def: "Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "activation of sodium export" NARROW [GOC:TermGenie]
synonym: "activation of sodium ion export" NARROW [GOC:TermGenie]
synonym: "activation of sodium ion export from cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of sodium export" RELATED [GOC:TermGenie]
synonym: "positive regulation of sodium ion export" RELATED []
synonym: "positive regulation of sodium ion export from cell" EXACT []
synonym: "up regulation of sodium export" RELATED [GOC:TermGenie]
synonym: "up regulation of sodium ion export" RELATED [GOC:TermGenie]
synonym: "up regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium export" RELATED [GOC:TermGenie]
synonym: "up-regulation of sodium ion export" RELATED [GOC:TermGenie]
synonym: "up-regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium export" RELATED [GOC:TermGenie]
synonym: "upregulation of sodium ion export" RELATED [GOC:TermGenie]
synonym: "upregulation of sodium ion export from cell" EXACT [GOC:TermGenie]
is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport
is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane
relationship: positively_regulates GO:0036376 ! sodium ion export across plasma membrane

[Term]
id: GO:1903279
name: regulation of calcium:sodium antiporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
subset: gocheck_obsoletion_candidate
synonym: "regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:1903280
name: obsolete negative regulation of calcium:sodium antiporter activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "down regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of calcium:sodium antiporter activity" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of sodium/calcium exchanger" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "negative regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "negative regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903281
name: positive regulation of calcium:sodium antiporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
subset: gocheck_obsoletion_candidate
synonym: "activation of calcium:sodium antiporter activity" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "activation of sodium/calcium exchanger" NARROW [GOC:TermGenie]
synonym: "activation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "positive regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "positive regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1903279 ! regulation of calcium:sodium antiporter activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:1903282
name: regulation of glutathione peroxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_obsoletion_candidate
synonym: "regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
is_a: GO:2000468 ! regulation of peroxidase activity

[Term]
id: GO:1903283
name: obsolete negative regulation of glutathione peroxidase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GSH peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903284
name: positive regulation of glutathione peroxidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]
subset: gocheck_obsoletion_candidate
synonym: "activation of glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of GSH peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "enhancement of GPX activity" EXACT [PMID:23507046]
synonym: "positive regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
is_a: GO:1903282 ! regulation of glutathione peroxidase activity
is_a: GO:2000470 ! positive regulation of peroxidase activity

[Term]
id: GO:1903285
name: positive regulation of hydrogen peroxide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]
synonym: "activation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "activation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "activation of H2O2 catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "activation of hydrogen peroxide breakdown" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide catabolism" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide degradation" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "activation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "positive regulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "positive regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "positive regulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "up regulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "up regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "up regulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "up-regulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "up-regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "up-regulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "upregulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "upregulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "upregulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process
is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process
relationship: positively_regulates GO:0042744 ! hydrogen peroxide catabolic process

[Term]
id: GO:1903286
name: regulation of potassium ion import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion import." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]
synonym: "regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "regulation of potassium ion uptake" EXACT [GOC:TermGenie]
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
relationship: regulates GO:1990573 ! potassium ion import across plasma membrane

[Term]
id: GO:1903287
name: negative regulation of potassium ion import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]
synonym: "down regulation of potassium import" BROAD [GOC:TermGenie]
synonym: "down regulation of potassium ion import" BROAD [GOC:TermGenie]
synonym: "down regulation of potassium ion uptake" BROAD [GOC:TermGenie]
synonym: "down-regulation of potassium import" BROAD [GOC:TermGenie]
synonym: "down-regulation of potassium ion import" BROAD [GOC:TermGenie]
synonym: "down-regulation of potassium ion uptake" BROAD [GOC:TermGenie]
synonym: "downregulation of potassium import" BROAD [GOC:TermGenie]
synonym: "downregulation of potassium ion import" BROAD [GOC:TermGenie]
synonym: "downregulation of potassium ion uptake" BROAD [GOC:TermGenie]
synonym: "inhibition of potassium import" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium ion import" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium ion uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of potassium import" BROAD [GOC:TermGenie]
synonym: "negative regulation of potassium ion import" BROAD []
synonym: "negative regulation of potassium ion uptake" BROAD [GOC:TermGenie]
is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport
is_a: GO:1903286 ! regulation of potassium ion import
relationship: negatively_regulates GO:1990573 ! potassium ion import across plasma membrane

[Term]
id: GO:1903288
name: positive regulation of potassium ion import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]
synonym: "activation of potassium import" NARROW [GOC:TermGenie]
synonym: "activation of potassium ion import" NARROW [GOC:TermGenie]
synonym: "activation of potassium ion uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "positive regulation of potassium ion import" BROAD []
synonym: "positive regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium import" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion uptake" EXACT [GOC:TermGenie]
is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport
is_a: GO:1903286 ! regulation of potassium ion import
relationship: positively_regulates GO:1990573 ! potassium ion import across plasma membrane

[Term]
id: GO:1903289
name: obsolete regulation of ATP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0043462

[Term]
id: GO:1903290
name: obsolete negative regulation of ATP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "down regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "downregulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0032780

[Term]
id: GO:1903291
name: obsolete positive regulation of ATP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "activation of ATP breakdown" NARROW [GOC:TermGenie]
synonym: "activation of ATP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ATP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ATP degradation" NARROW [GOC:TermGenie]
synonym: "activation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "upregulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP hydrolysis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0032781

[Term]
id: GO:1903292
name: protein localization to Golgi membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]
synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie]
is_a: GO:0034067 ! protein localization to Golgi apparatus
is_a: GO:0072657 ! protein localization to membrane

[Term]
id: GO:1903293
name: phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807]
comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1903294
name: regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
relationship: regulates GO:0061535 ! glutamate secretion, neurotransmission

[Term]
id: GO:1903295
name: negative regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
synonym: "down regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0014050 ! negative regulation of glutamate secretion
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051967 ! negative regulation of synaptic transmission, glutamatergic
is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission
relationship: negatively_regulates GO:0061535 ! glutamate secretion, neurotransmission

[Term]
id: GO:1903296
name: positive regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
synonym: "activation of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014049 ! positive regulation of glutamate secretion
is_a: GO:0051968 ! positive regulation of synaptic transmission, glutamatergic
is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission
relationship: positively_regulates GO:0061535 ! glutamate secretion, neurotransmission

[Term]
id: GO:1903297
name: regulation of hypoxia-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of hypoxia-induced apoptosis" RELATED [GOC:bf]
synonym: "regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf]
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia

[Term]
id: GO:1903298
name: negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24553947]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hypoxia" NARROW [GOC:TermGenie]
synonym: "negative regulation of hypoxia-induced apoptosis" RELATED [GOC:bf]
synonym: "negative regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf]
synonym: "protection against hypoxia-induced apoptosis" RELATED [GOC:bf]
is_a: GO:1900038 ! negative regulation of cellular response to hypoxia
is_a: GO:1903297 ! regulation of hypoxia-induced intrinsic apoptotic signaling pathway
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia

[Term]
id: GO:1903299
name: regulation of hexokinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:1903300
name: negative regulation of hexokinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "down regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "down regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "downregulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "downregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase (phosphorylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase D" RELATED [GOC:TermGenie]
synonym: "inhibition of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "inhibition of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1903299 ! regulation of hexokinase activity

[Term]
id: GO:1903301
name: positive regulation of hexokinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
subset: gocheck_obsoletion_candidate
synonym: "activation of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase (phosphorylating)" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "activation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "activation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "up regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "up regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "upregulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "upregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:1903299 ! regulation of hexokinase activity

[Term]
id: GO:1903302
name: regulation of pyruvate kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1903303
name: obsolete negative regulation of pyruvate kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903304
name: obsolete positive regulation of pyruvate kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of pyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903305
name: regulation of regulated secretory pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]
comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
is_a: GO:0017157 ! regulation of exocytosis
relationship: regulates GO:0045055 ! regulated exocytosis

[Term]
id: GO:1903306
name: negative regulation of regulated secretory pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]
comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
synonym: "down regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of regulated secretory pathway" NARROW [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903305 ! regulation of regulated secretory pathway
relationship: negatively_regulates GO:0045055 ! regulated exocytosis

[Term]
id: GO:1903307
name: positive regulation of regulated secretory pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]
comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
synonym: "activation of regulated secretory pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of regulated secretory pathway" EXACT [GOC:TermGenie]
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903305 ! regulation of regulated secretory pathway
relationship: positively_regulates GO:0045055 ! regulated exocytosis

[Term]
id: GO:1903311
name: regulation of mRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of mRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0016071 ! mRNA metabolic process

[Term]
id: GO:1903312
name: negative regulation of mRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1903311 ! regulation of mRNA metabolic process
relationship: negatively_regulates GO:0016071 ! mRNA metabolic process

[Term]
id: GO:1903313
name: positive regulation of mRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of mRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of mRNA metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903311 ! regulation of mRNA metabolic process
relationship: positively_regulates GO:0016071 ! mRNA metabolic process

[Term]
id: GO:1903314
name: regulation of nitrogen cycle metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:1903315
name: negative regulation of nitrogen cycle metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of nitrogen cycle metabolic process" NARROW [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
relationship: negatively_regulates GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:1903316
name: positive regulation of nitrogen cycle metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of nitrogen cycle metabolic process" NARROW [GOC:TermGenie]
synonym: "up regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
relationship: positively_regulates GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:1903317
name: regulation of protein maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0051604 ! protein maturation

[Term]
id: GO:1903318
name: negative regulation of protein maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein maturation" NARROW [GOC:TermGenie]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1903317 ! regulation of protein maturation
relationship: negatively_regulates GO:0051604 ! protein maturation

[Term]
id: GO:1903319
name: positive regulation of protein maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of protein maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1903317 ! regulation of protein maturation
relationship: positively_regulates GO:0051604 ! protein maturation

[Term]
id: GO:1903320
name: regulation of protein modification by small protein conjugation or removal
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:1901873 ! regulation of post-translational protein modification
relationship: regulates GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:1903321
name: negative regulation of protein modification by small protein conjugation or removal
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "downregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "inhibition of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie]
is_a: GO:1901874 ! negative regulation of post-translational protein modification
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:1903322
name: positive regulation of protein modification by small protein conjugation or removal
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie]
synonym: "up regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "upregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
is_a: GO:1901875 ! positive regulation of post-translational protein modification
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: positively_regulates GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:1903323
name: regulation of snoRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:1903324
name: negative regulation of snoRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of snoRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of snoRNA metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1903323 ! regulation of snoRNA metabolic process
relationship: negatively_regulates GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:1903325
name: positive regulation of snoRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of snoRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of snoRNA metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of snoRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903323 ! regulation of snoRNA metabolic process
relationship: positively_regulates GO:0016074 ! sno(s)RNA metabolic process

[Term]
id: GO:1903326
name: regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0006399 ! tRNA metabolic process

[Term]
id: GO:1903327
name: negative regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
relationship: negatively_regulates GO:0006399 ! tRNA metabolic process

[Term]
id: GO:1903328
name: positive regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of tRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tRNA metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
relationship: positively_regulates GO:0006399 ! tRNA metabolic process

[Term]
id: GO:1903329
name: regulation of iron-sulfur cluster assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0016226 ! iron-sulfur cluster assembly

[Term]
id: GO:1903330
name: negative regulation of iron-sulfur cluster assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of iron-sulfur cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of iron-sulphur cluster assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
relationship: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly

[Term]
id: GO:1903331
name: positive regulation of iron-sulfur cluster assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of iron-sulfur cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of iron-sulphur cluster assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
relationship: positively_regulates GO:0016226 ! iron-sulfur cluster assembly

[Term]
id: GO:1903332
name: regulation of protein folding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0006457 ! protein folding

[Term]
id: GO:1903333
name: negative regulation of protein folding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "down regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "down regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "down regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "down regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "down regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down-regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "down-regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "downregulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "downregulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "downregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "downregulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "downregulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "downregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "downregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of protein folding" EXACT [GOC:TermGenie]
synonym: "inhibition of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "inhibition of chaperone activity" RELATED [GOC:TermGenie]
synonym: "inhibition of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "inhibition of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "inhibition of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "inhibition of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "inhibition of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of protein folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903332 ! regulation of protein folding
relationship: negatively_regulates GO:0006457 ! protein folding

[Term]
id: GO:1903334
name: positive regulation of protein folding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "activation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "activation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "activation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "activation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "activation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "activation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "activation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "activation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "activation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "activation of protein folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "up regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "up regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "up regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "up regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "up regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up-regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "up-regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "upregulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "upregulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "upregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "upregulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "upregulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "upregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "upregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of protein folding" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903332 ! regulation of protein folding
relationship: positively_regulates GO:0006457 ! protein folding

[Term]
id: GO:1903335
name: regulation of vacuolar transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:0007034 ! vacuolar transport

[Term]
id: GO:1903336
name: negative regulation of vacuolar transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
relationship: negatively_regulates GO:0007034 ! vacuolar transport

[Term]
id: GO:1903337
name: positive regulation of vacuolar transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie]
synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
relationship: positively_regulates GO:0007034 ! vacuolar transport

[Term]
id: GO:1903338
name: regulation of cell wall organization or biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:1903339
name: negative regulation of cell wall organization or biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: negatively_regulates GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:1903340
name: positive regulation of cell wall organization or biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie]
synonym: "activation of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: positively_regulates GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:1903341
name: regulation of meiotic DNA double-strand break formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0042138 ! meiotic DNA double-strand break formation

[Term]
id: GO:1903342
name: negative regulation of meiotic DNA double-strand break formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240]
synonym: "down regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0042138 ! meiotic DNA double-strand break formation

[Term]
id: GO:1903343
name: positive regulation of meiotic DNA double-strand break formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240]
synonym: "activation of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie]
synonym: "up regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0042138 ! meiotic DNA double-strand break formation

[Term]
id: GO:1903344
name: regulation of protein polyglycylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0018094 ! protein polyglycylation

[Term]
id: GO:1903345
name: negative regulation of protein polyglycylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie]
synonym: "down regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polyglycylation" NARROW [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1903344 ! regulation of protein polyglycylation
relationship: negatively_regulates GO:0018094 ! protein polyglycylation

[Term]
id: GO:1903346
name: positive regulation of protein polyglycylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie, PMID:21298005]
synonym: "activation of protein polyglycylation" NARROW [GOC:TermGenie]
synonym: "up regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polyglycylation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1903344 ! regulation of protein polyglycylation
relationship: positively_regulates GO:0018094 ! protein polyglycylation

[Term]
id: GO:1903347
name: negative regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]
synonym: "down regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tight junction assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of tight junction formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:2000810 ! regulation of bicellular tight junction assembly
relationship: negatively_regulates GO:0070830 ! bicellular tight junction assembly

[Term]
id: GO:1903348
name: positive regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]
synonym: "activation of tight junction assembly" NARROW [GOC:TermGenie]
synonym: "activation of tight junction formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:1901890 ! positive regulation of cell junction assembly
is_a: GO:2000810 ! regulation of bicellular tight junction assembly
relationship: positively_regulates GO:0070830 ! bicellular tight junction assembly

[Term]
id: GO:1903349
name: omegasome membrane
namespace: cellular_component
def: "Any membrane that is part of an omegasome." [GO_REF:0000064, GOC:mf, GOC:TermGenie, PMID:18725538, PMID:24591649]
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:1990462 ! omegasome

[Term]
id: GO:1903350
name: response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
is_a: GO:0071869 ! response to catecholamine

[Term]
id: GO:1903351
name: cellular response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:1903350 ! response to dopamine

[Term]
id: GO:1903352
name: L-ornithine transmembrane transport
namespace: biological_process
def: "The directed movement of L-ornithine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
is_a: GO:0015822 ! ornithine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903353
name: regulation of nucleus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282]
synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0006997 ! nucleus organization

[Term]
id: GO:1903354
name: regulation of distal tip cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0097628 ! distal tip cell migration

[Term]
id: GO:1903355
name: negative regulation of distal tip cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]
synonym: "down regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of distal tip cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1903354 ! regulation of distal tip cell migration
relationship: negatively_regulates GO:0097628 ! distal tip cell migration

[Term]
id: GO:1903356
name: positive regulation of distal tip cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]
synonym: "activation of distal tip cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of distal tip cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1903354 ! regulation of distal tip cell migration
relationship: positively_regulates GO:0097628 ! distal tip cell migration

[Term]
id: GO:1903357
name: regulation of transcription initiation by RNA polymerase I
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter." [GO_REF:0000058, GOC:TermGenie, PMID:9092673]
synonym: "regulation of transcription initiation from RNA polymerase I promoter" EXACT []
synonym: "regulation of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" NARROW []
is_a: GO:0006356 ! regulation of transcription by RNA polymerase I
is_a: GO:2000142 ! regulation of DNA-templated transcription initiation
relationship: regulates GO:0006361 ! transcription initiation at RNA polymerase I promoter

[Term]
id: GO:1903358
name: regulation of Golgi organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]
synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie]
synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007030 ! Golgi organization

[Term]
id: GO:1903359
name: lateral cortical node assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a lateral cortical node." [GO_REF:0000079, GOC:TermGenie, PMID:25009287]
synonym: "lateral cortical node formation" EXACT [GOC:TermGenie]
synonym: "Skb1-containing cortical node assembly" EXACT [GOC:TermGenie]
synonym: "Skb1-containing cortical node formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1903360
name: protein localization to lateral cortical node
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a lateral cortical node." [GO_REF:0000087, GOC:TermGenie, PMID:25009287]
synonym: "protein localisation in lateral cortical node" EXACT [GOC:TermGenie]
synonym: "protein localisation to lateral cortical node" EXACT [GOC:TermGenie]
synonym: "protein localization in lateral cortical node" EXACT [GOC:TermGenie]
is_a: GO:0072697 ! protein localization to cell cortex

[Term]
id: GO:1903361
name: protein localization to basolateral plasma membrane
namespace: biological_process
alt_id: GO:0061467
def: "Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]
synonym: "basolateral protein localization" EXACT []
synonym: "protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1903365
name: regulation of fear response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "regulation of physiological fear response" EXACT [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0042596 ! fear response

[Term]
id: GO:1903366
name: negative regulation of fear response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "down regulation of fear response" EXACT [GOC:TermGenie]
synonym: "down regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "down-regulation of fear response" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "downregulation of fear response" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "inhibition of fear response" NARROW [GOC:TermGenie]
synonym: "inhibition of physiological fear response" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological fear response" EXACT [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903365 ! regulation of fear response
relationship: negatively_regulates GO:0042596 ! fear response

[Term]
id: GO:1903367
name: positive regulation of fear response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "activation of fear response" NARROW [GOC:TermGenie]
synonym: "activation of physiological fear response" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "up regulation of fear response" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "up-regulation of fear response" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "upregulation of fear response" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological fear response" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903365 ! regulation of fear response
relationship: positively_regulates GO:0042596 ! fear response

[Term]
id: GO:1903368
name: regulation of foraging behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0060756 ! foraging behavior

[Term]
id: GO:1903369
name: negative regulation of foraging behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "down regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "down-regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "downregulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "inhibition of foraging behavior" NARROW [GOC:TermGenie]
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1903368 ! regulation of foraging behavior
relationship: negatively_regulates GO:0060756 ! foraging behavior

[Term]
id: GO:1903370
name: positive regulation of foraging behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "activation of foraging behavior" NARROW [GOC:TermGenie]
synonym: "up regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "up-regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "upregulation of foraging behavior" EXACT [GOC:TermGenie]
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1903368 ! regulation of foraging behavior
relationship: positively_regulates GO:0060756 ! foraging behavior

[Term]
id: GO:1903371
name: regulation of endoplasmic reticulum tubular network organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]
synonym: "regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "regulation of ER tubular network organization" EXACT [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0071786 ! endoplasmic reticulum tubular network organization

[Term]
id: GO:1903372
name: negative regulation of endoplasmic reticulum tubular network organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]
synonym: "down regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "down regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "downregulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie]
synonym: "inhibition of ER tubular network organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of ER tubular network organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER tubular network organization" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization
relationship: negatively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization

[Term]
id: GO:1903373
name: positive regulation of endoplasmic reticulum tubular network organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]
synonym: "activation of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie]
synonym: "activation of ER tubular network organisation" NARROW [GOC:TermGenie]
synonym: "activation of ER tubular network organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "up regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "upregulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of ER tubular network organization" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization
relationship: positively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization

[Term]
id: GO:1903374
name: obsolete subarachnoid space development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of a subarachnoid space over time, from its formation to the mature structure." [GO_REF:0000094, GOC:cjm, GOC:TermGenie, Wikipedia:Subarachnoid_space]
comment: This term was obsoleted because it does not represent a real process. While subarachnoid space is a valid anatomical structure, it is formed by the development of the structures that surround it.
synonym: "cavitas subarachnoidea development" RELATED [GOC:TermGenie]
synonym: "cavum subarachnoideale development" RELATED [GOC:TermGenie]
synonym: "spatium leptomeningeum development" RELATED [GOC:TermGenie]
synonym: "spatium subarachnoideum development" RELATED [GOC:TermGenie]
synonym: "subarachnoid cavity development" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903375
name: facioacoustic ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]
synonym: "acoustico-facial VII-VIII ganglion complex development" EXACT [UBERON:0012175]
synonym: "acousticofacial ganglion development" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion complex VII-VIII development" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion development" EXACT [GOC:TermGenie]
synonym: "facio-acoustic VII-VIII ganglion complex development" EXACT [GOC:TermGenie]
is_a: GO:0061550 ! cranial ganglion development

[Term]
id: GO:1903376
name: regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT []
synonym: "regulation of oxidative stress-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of oxidative stress-induced neuronal apoptosis" BROAD [GOC:TermGenie]
is_a: GO:0043523 ! regulation of neuron apoptotic process
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
relationship: regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress

[Term]
id: GO:1903377
name: negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595]
synonym: "down regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT []
synonym: "negative regulation of oxidative stress-induced neuron apoptosis" EXACT [GOC:bf]
synonym: "neuroprotection against oxidative stress-induced apoptosis" RELATED [GOC:bf]
synonym: "protection against oxidative stress-induced neuron apoptosis" RELATED [GOC:bf]
synonym: "protection against oxidative stress-induced neuronal apoptosis" RELATED [GOC:bf]
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress

[Term]
id: GO:1903378
name: positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "activation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT []
synonym: "up regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "up regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "upregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress

[Term]
id: GO:1903379
name: regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0060623 ! regulation of chromosome condensation
relationship: regulates GO:0007076 ! mitotic chromosome condensation

[Term]
id: GO:1903380
name: positive regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903379 ! regulation of mitotic chromosome condensation
is_a: GO:1905821 ! positive regulation of chromosome condensation
relationship: positively_regulates GO:0007076 ! mitotic chromosome condensation

[Term]
id: GO:1903381
name: regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of ER stress-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT []
is_a: GO:0043523 ! regulation of neuron apoptotic process
is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
relationship: regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

[Term]
id: GO:1903382
name: negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]
synonym: "down regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of ER stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT []
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903381 ! regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

[Term]
id: GO:1903383
name: regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of H2O2-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT []
is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide

[Term]
id: GO:1903384
name: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23261939]
synonym: "down regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "inhibition of H2O2-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "negative regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT []
synonym: "protection against H2O2-induced neuron apoptosis" RELATED [GOC:bf]
synonym: "protection against hydrogen peroxide-induced neuron apoptosis" RELATED [GOC:bf]
is_a: GO:1903377 ! negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
is_a: GO:1903383 ! regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
is_a: GO:1903751 ! negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: negatively_regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide

[Term]
id: GO:1903385
name: regulation of homophilic cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules

[Term]
id: GO:1903386
name: negative regulation of homophilic cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "down regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "inhibition of homophilic cell adhesion" NARROW [GOC:TermGenie]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:1903385 ! regulation of homophilic cell adhesion
relationship: negatively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules

[Term]
id: GO:1903387
name: positive regulation of homophilic cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "activation of homophilic cell adhesion" NARROW [GOC:TermGenie]
synonym: "up regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:1903385 ! regulation of homophilic cell adhesion
relationship: positively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules

[Term]
id: GO:1903388
name: regulation of synaptic vesicle uncoating
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]
synonym: "regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
is_a: GO:1901879 ! regulation of protein depolymerization
relationship: regulates GO:0016191 ! synaptic vesicle uncoating

[Term]
id: GO:1903389
name: negative regulation of synaptic vesicle uncoating
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]
synonym: "down regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle uncoating" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
is_a: GO:1900243 ! negative regulation of synaptic vesicle endocytosis
is_a: GO:1901880 ! negative regulation of protein depolymerization
is_a: GO:1903388 ! regulation of synaptic vesicle uncoating
relationship: negatively_regulates GO:0016191 ! synaptic vesicle uncoating

[Term]
id: GO:1903390
name: positive regulation of synaptic vesicle uncoating
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]
synonym: "activation of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle uncoating" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
is_a: GO:1901881 ! positive regulation of protein depolymerization
is_a: GO:1903388 ! regulation of synaptic vesicle uncoating
relationship: positively_regulates GO:0016191 ! synaptic vesicle uncoating

[Term]
id: GO:1903391
name: regulation of adherens junction organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "regulation of adherens junction organisation" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0034332 ! adherens junction organization

[Term]
id: GO:1903392
name: negative regulation of adherens junction organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "down regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "down regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "downregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "inhibition of adherens junction assembly and maintenance" NARROW [GOC:TermGenie]
synonym: "inhibition of adherens junction organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of adherens junction organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "negative regulation of adherens junction organisation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903391 ! regulation of adherens junction organization
relationship: negatively_regulates GO:0034332 ! adherens junction organization

[Term]
id: GO:1903393
name: positive regulation of adherens junction organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "activation of adherens junction assembly and maintenance" NARROW [GOC:TermGenie]
synonym: "activation of adherens junction organisation" NARROW [GOC:TermGenie]
synonym: "activation of adherens junction organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "positive regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "up regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "upregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of adherens junction organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903391 ! regulation of adherens junction organization
relationship: positively_regulates GO:0034332 ! adherens junction organization

[Term]
id: GO:1903394
name: protein localization to kinetochore involved in kinetochore assembly
namespace: biological_process
def: "Any protein localization to kinetochore that is involved in kinetochore assembly." [GO_REF:0000060, GOC:TermGenie, PMID:15369671]
synonym: "condensin localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in kinetochore assembly" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie]
is_a: GO:0034501 ! protein localization to kinetochore
relationship: part_of GO:0051382 ! kinetochore assembly

[Term]
id: GO:1903395
name: regulation of secondary cell septum biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
relationship: regulates GO:1990344 ! secondary cell septum biogenesis

[Term]
id: GO:1903396
name: negative regulation of secondary cell septum biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]
synonym: "down regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary cell septum biogenesis" NARROW [GOC:TermGenie]
is_a: GO:0140280 ! negative regulation of mitotic division septum assembly
is_a: GO:1903395 ! regulation of secondary cell septum biogenesis
relationship: negatively_regulates GO:1990344 ! secondary cell septum biogenesis

[Term]
id: GO:1903397
name: positive regulation of secondary cell septum biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]
synonym: "activation of secondary cell septum biogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0140281 ! positive regulation of mitotic division septum assembly
is_a: GO:1903395 ! regulation of secondary cell septum biogenesis
relationship: positively_regulates GO:1990344 ! secondary cell septum biogenesis

[Term]
id: GO:1903398
name: obsolete regulation of m7G(5')pppN diphosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607]
comment: This term was obsoleted because the obsoleted EC was obsoleted.
synonym: "regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903399
name: obsolete positive regulation of m7G(5')pppN diphosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607]
comment: This term was obsoleted because the obsoleted EC was obsoleted.
synonym: "activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of decapase activity" RELATED [GOC:TermGenie]
synonym: "activation of M(7)G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of m7G(5')pppN diphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of m7G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903401
name: L-lysine transmembrane transport
namespace: biological_process
def: "The directed movement of L-lysine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
is_a: GO:1902022 ! L-lysine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903402
name: regulation of renal phosphate excretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]
synonym: "regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
is_a: GO:0044062 ! regulation of excretion
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:0044722 ! renal phosphate excretion

[Term]
id: GO:1903403
name: negative regulation of renal phosphate excretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]
synonym: "down regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "down regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "downregulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "downregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "inhibition of renal phosphate excretion" NARROW [GOC:TermGenie]
synonym: "inhibition of renal phosphate ion excretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903402 ! regulation of renal phosphate excretion
relationship: negatively_regulates GO:0044722 ! renal phosphate excretion

[Term]
id: GO:1903404
name: positive regulation of renal phosphate excretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]
synonym: "activation of renal phosphate excretion" NARROW [GOC:TermGenie]
synonym: "activation of renal phosphate ion excretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "up regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "up regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "upregulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "upregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903402 ! regulation of renal phosphate excretion
relationship: positively_regulates GO:0044722 ! renal phosphate excretion

[Term]
id: GO:1903405
name: protein localization to nuclear body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849]
synonym: "protein localisation in nuclear body" EXACT [GOC:TermGenie]
synonym: "protein localisation to nuclear body" EXACT [GOC:TermGenie]
synonym: "protein localization in nuclear body" EXACT [GOC:TermGenie]
is_a: GO:1990173 ! protein localization to nucleoplasm

[Term]
id: GO:1903406
name: regulation of P-type sodium:potassium-exchanging transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
subset: gocheck_obsoletion_candidate
synonym: "regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "regulation of sodium pump" BROAD [GOC:TermGenie]
synonym: "regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sodium:potassium-exchanging ATPase activity" EXACT []
is_a: GO:0043462 ! regulation of ATP-dependent activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:1903407
name: negative regulation of P-type sodium:potassium-exchanging transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "down regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "down regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "down-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "down-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "downregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "downregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "downregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "inhibition of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "inhibition of Na+,K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na,K-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "inhibition of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "negative regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "negative regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sodium:potassium-exchanging ATPase activity" EXACT []
is_a: GO:0032780 ! negative regulation of ATP-dependent activity
is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity
is_a: GO:1903406 ! regulation of P-type sodium:potassium-exchanging transporter activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:1903408
name: positive regulation of P-type sodium:potassium-exchanging transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
subset: gocheck_obsoletion_candidate
synonym: "activation of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "activation of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "activation of Na+,K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na,K-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "activation of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "positive regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "positive regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sodium:potassium-exchanging ATPase activity" EXACT []
synonym: "up regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "up regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "up regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "up-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "up-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "upregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "upregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "upregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATP-dependent activity
is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity
is_a: GO:1903406 ! regulation of P-type sodium:potassium-exchanging transporter activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:1903409
name: reactive oxygen species biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species generation" RELATED [PMID:24252804]
synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "ROS formation" RELATED []
synonym: "ROS generation" RELATED [PMID:24252804]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:1903412
name: response to bile acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903413
name: cellular response to bile acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903412 ! response to bile acid

[Term]
id: GO:1903415
name: flavonoid transport from endoplasmic reticulum to plant-type vacuole
namespace: biological_process
def: "The directed movement of flavonoid from endoplasmic reticulum to plant-type vacuole." [GO_REF:0000078, GOC:tb, GOC:TermGenie, PMID:25116949]
synonym: "flavonoid accumulation in vacuole" RELATED []
is_a: GO:0006810 ! transport

[Term]
id: GO:1903416
name: response to glycoside
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus." [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970]
synonym: "cellular response to ouabain" RELATED [CHEBI:472805]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903418
name: protein localization to plasma membrane of cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:25157670, PMID:27852900]
synonym: "protein localisation in plasma membrane of cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to plasma membrane of cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in plasma membrane of cell tip" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990151 ! protein localization to cell tip
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1903419
name: protein localization to cortical endoplasmic reticulum
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cortical endoplasmic reticulum." [GO_REF:0000087, GOC:TermGenie, PMID:25103238]
synonym: "protein localisation in cortical endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "protein localisation to cortical endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "protein localization in cortical endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "protein localization to cortical ER" EXACT []
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:1903420 ! protein localization to endoplasmic reticulum tubular network

[Term]
id: GO:1903420
name: protein localization to endoplasmic reticulum tubular network
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network." [GO_REF:0000087, GOC:TermGenie, PMID:25103238]
synonym: "protein localisation in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie]
synonym: "protein localisation to endoplasmic reticulum tubular network" EXACT [GOC:TermGenie]
synonym: "protein localization in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie]
synonym: "protein localization to tubular ER" RELATED [PMID:25103238]
is_a: GO:0070972 ! protein localization to endoplasmic reticulum

[Term]
id: GO:1903421
name: regulation of synaptic vesicle recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]
comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype
synonym: "regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0036465 ! synaptic vesicle recycling

[Term]
id: GO:1903422
name: negative regulation of synaptic vesicle recycling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]
comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype
synonym: "down regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "down-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "downregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "downregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "inhibition of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "inhibition of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "negative regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "negative regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1903421 ! regulation of synaptic vesicle recycling
relationship: negatively_regulates GO:0036465 ! synaptic vesicle recycling

[Term]
id: GO:1903423
name: positive regulation of synaptic vesicle recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]
comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype
synonym: "activation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "activation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "positive regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "positive regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "up-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "upregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "upregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1903421 ! regulation of synaptic vesicle recycling
relationship: positively_regulates GO:0036465 ! synaptic vesicle recycling

[Term]
id: GO:1903424
name: fluoride transmembrane transport
namespace: biological_process
def: "The process in which fluoride is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24173035]
synonym: "fluoride membrane transport" EXACT []
synonym: "transmembrane fluoride transport" EXACT []
is_a: GO:0098656 ! monoatomic anion transmembrane transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:1903425
name: fluoride transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fluoride from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, PMID:24173035]
is_a: GO:0008509 ! monoatomic anion transmembrane transporter activity
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:1903426
name: regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "regulation of ROS generation" RELATED [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
relationship: regulates GO:1903409 ! reactive oxygen species biosynthetic process

[Term]
id: GO:1903427
name: negative regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "down regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "down regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "downregulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species formation" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ROS formation" RELATED [GOC:TermGenie]
synonym: "inhibition of ROS generation" RELATED [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "prevention of ROS generation" EXACT [PMID:24252804]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
relationship: negatively_regulates GO:1903409 ! reactive oxygen species biosynthetic process

[Term]
id: GO:1903428
name: positive regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "activation of reactive oxygen species anabolism" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species formation" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "activation of reactive oxygen species synthesis" NARROW [GOC:TermGenie]
synonym: "activation of ROS formation" RELATED [GOC:TermGenie]
synonym: "activation of ROS generation" RELATED [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "up regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "upregulation of ROS generation" RELATED [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
relationship: positively_regulates GO:1903409 ! reactive oxygen species biosynthetic process

[Term]
id: GO:1903429
name: regulation of cell maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0048469 ! cell maturation

[Term]
id: GO:1903430
name: negative regulation of cell maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
relationship: negatively_regulates GO:0048469 ! cell maturation

[Term]
id: GO:1903431
name: positive regulation of cell maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "activation of cell maturation" NARROW [GOC:TermGenie]
synonym: "activation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
relationship: positively_regulates GO:0048469 ! cell maturation

[Term]
id: GO:1903432
name: regulation of TORC1 signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie]
synonym: "regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032006 ! regulation of TOR signaling
relationship: regulates GO:0038202 ! TORC1 signaling

[Term]
id: GO:1903433
name: regulation of constitutive secretory pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]
is_a: GO:0017157 ! regulation of exocytosis
relationship: regulates GO:0045054 ! constitutive secretory pathway

[Term]
id: GO:1903434
name: negative regulation of constitutive secretory pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]
synonym: "down regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of constitutive secretory pathway" NARROW [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903433 ! regulation of constitutive secretory pathway
relationship: negatively_regulates GO:0045054 ! constitutive secretory pathway

[Term]
id: GO:1903435
name: positive regulation of constitutive secretory pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]
synonym: "activation of constitutive secretory pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903433 ! regulation of constitutive secretory pathway
relationship: positively_regulates GO:0045054 ! constitutive secretory pathway

[Term]
id: GO:1903436
name: regulation of mitotic cytokinetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:1902412 ! regulation of mitotic cytokinesis
relationship: regulates GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1903437
name: negative regulation of mitotic cytokinetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic cytokinetic process" NARROW [GOC:TermGenie]
is_a: GO:1902413 ! negative regulation of mitotic cytokinesis
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
relationship: negatively_regulates GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1903438
name: positive regulation of mitotic cytokinetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of mitotic cytokinetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
is_a: GO:1903490 ! positive regulation of mitotic cytokinesis
relationship: positively_regulates GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1903439
name: calcitonin family receptor complex
namespace: cellular_component
def: "A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0097648 ! G protein-coupled receptor complex

[Term]
id: GO:1903440
name: amylin receptor complex
namespace: cellular_component
def: "A protein complex which is capable of amylin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:1903439 ! calcitonin family receptor complex

[Term]
id: GO:1903441
name: protein localization to ciliary membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371]
synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1903442
name: response to lipoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:1903443
name: cellular response to lipoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1903442 ! response to lipoic acid

[Term]
id: GO:1903444
name: negative regulation of brown fat cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23977283]
synonym: "down regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of brown fat cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of brown fat cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of brown fat cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of brown adipocyte cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of brown adipocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of brown fat cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045599 ! negative regulation of fat cell differentiation
is_a: GO:0090335 ! regulation of brown fat cell differentiation
relationship: negatively_regulates GO:0050873 ! brown fat cell differentiation

[Term]
id: GO:1903445
name: protein transport from ciliary membrane to plasma membrane
namespace: biological_process
def: "The directed movement of protein from ciliary membrane to plasma membrane." [GO_REF:0000078, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371]
is_a: GO:0032594 ! protein transport within lipid bilayer
is_a: GO:0061951 ! establishment of protein localization to plasma membrane

[Term]
id: GO:1903446
name: geraniol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]
synonym: "geraniol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:1903447
name: geraniol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]
synonym: "geraniol breakdown" EXACT [GOC:TermGenie]
synonym: "geraniol catabolism" EXACT [GOC:TermGenie]
synonym: "geraniol degradation" EXACT [GOC:TermGenie]
is_a: GO:0016095 ! polyprenol catabolic process
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0120256 ! olefinic compound catabolic process
is_a: GO:1903446 ! geraniol metabolic process

[Term]
id: GO:1903448
name: geraniol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]
synonym: "geraniol anabolism" EXACT [GOC:TermGenie]
synonym: "geraniol biosynthesis" EXACT [GOC:TermGenie]
synonym: "geraniol formation" EXACT [GOC:TermGenie]
synonym: "geraniol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1903446 ! geraniol metabolic process

[Term]
id: GO:1903449
name: androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of androst-4-ene-3,17-dione." [GO_REF:0000068, GOC:mr, GOC:TermGenie, PMID:2028480, PMID:4149619]
synonym: "androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "androstenedione biosynthetic process" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process

[Term]
id: GO:1903450
name: regulation of G1 to G0 transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]
synonym: "regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of stationary phase" RELATED [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0070314 ! G1 to G0 transition

[Term]
id: GO:1903451
name: negative regulation of G1 to G0 transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]
synonym: "down regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "down regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "down regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "down regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "down regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "down-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "down-regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "downregulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "downregulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "downregulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "downregulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "downregulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "inhibition of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "inhibition of establishment of cell quiescence" NARROW [GOC:TermGenie]
synonym: "inhibition of G1 to G0 transition" NARROW [GOC:TermGenie]
synonym: "inhibition of G1/G0 transition" NARROW [GOC:TermGenie]
synonym: "inhibition of stationary phase" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "negative regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "negative regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "negative regulation of stationary phase" RELATED [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1903450 ! regulation of G1 to G0 transition
relationship: negatively_regulates GO:0070314 ! G1 to G0 transition

[Term]
id: GO:1903452
name: positive regulation of G1 to G0 transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]
synonym: "activation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "activation of establishment of cell quiescence" NARROW [GOC:TermGenie]
synonym: "activation of G1 to G0 transition" NARROW [GOC:TermGenie]
synonym: "activation of G1/G0 transition" NARROW [GOC:TermGenie]
synonym: "activation of stationary phase" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "positive regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "positive regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "positive regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "up regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "up regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "up regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "up regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "up regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "up-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "upregulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "upregulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "upregulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "upregulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "upregulation of stationary phase" RELATED [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903450 ! regulation of G1 to G0 transition
relationship: positively_regulates GO:0070314 ! G1 to G0 transition

[Term]
id: GO:1903453
name: obsolete RNA interference involved in olfactory learning
namespace: biological_process
def: "OBSOLETE. Any RNA interference that is involved in olfactory learning." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:23993094]
comment: This term was obsoleted because it does not represent a specific pathway.
synonym: "posttranscriptional gene silencing by siRNA involved in olfactory learning" EXACT [GOC:TermGenie]
synonym: "RNAi involved in olfactory learning" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903454
name: regulation of androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]
synonym: "regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process

[Term]
id: GO:1903455
name: negative regulation of androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]
synonym: "down regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of androstenedione" NARROW [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process
relationship: negatively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process

[Term]
id: GO:1903456
name: positive regulation of androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]
synonym: "activation of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie]
synonym: "activation of androstenedione" NARROW [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process
relationship: positively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process

[Term]
id: GO:1903457
name: lactate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:8941775]
synonym: "lactate breakdown" EXACT [GOC:TermGenie]
synonym: "lactate catabolism" EXACT [GOC:TermGenie]
synonym: "lactate degradation" EXACT [GOC:TermGenie]
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:1903459
name: mitotic DNA replication lagging strand elongation
namespace: biological_process
def: "Any lagging strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "lagging strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "lagging strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "lagging strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "lagging strand elongation involved in mitotic DNA replication" EXACT []
synonym: "lagging strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "lagging strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0006273 ! lagging strand elongation
is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication

[Term]
id: GO:1903460
name: mitotic DNA replication leading strand elongation
namespace: biological_process
def: "Any leading strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "leading strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "leading strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "leading strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "leading strand elongation involved in mitotic DNA replication" EXACT []
synonym: "leading strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "leading strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0006272 ! leading strand elongation
is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication

[Term]
id: GO:1903461
name: Okazaki fragment processing involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "DNA replication, Okazaki fragment processing involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0033567 ! DNA replication, Okazaki fragment processing
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1903463
name: regulation of mitotic cell cycle DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
relationship: regulates GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1903464
name: negative regulation of mitotic cell cycle DNA replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "down regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication
is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication
relationship: negatively_regulates GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1903465
name: positive regulation of mitotic cell cycle DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "activation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "activation of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication
relationship: positively_regulates GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1903466
name: regulation of mitotic DNA replication initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0030174 ! regulation of DNA-templated DNA replication initiation
is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication
relationship: regulates GO:1902975 ! mitotic DNA replication initiation

[Term]
id: GO:1903467
name: negative regulation of mitotic DNA replication initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0032297 ! negative regulation of DNA-templated DNA replication initiation
is_a: GO:1903464 ! negative regulation of mitotic cell cycle DNA replication
is_a: GO:1903466 ! regulation of mitotic DNA replication initiation
relationship: negatively_regulates GO:1902975 ! mitotic DNA replication initiation

[Term]
id: GO:1903468
name: positive regulation of DNA replication initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "activation of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0032298 ! positive regulation of DNA-templated DNA replication initiation
is_a: GO:1903465 ! positive regulation of mitotic cell cycle DNA replication
is_a: GO:1903466 ! regulation of mitotic DNA replication initiation
relationship: positively_regulates GO:1902975 ! mitotic DNA replication initiation

[Term]
id: GO:1903469
name: removal of RNA primer involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA replication, removal of RNA primer that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "DNA replication, removal of RNA primer involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0043137 ! DNA replication, removal of RNA primer
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1903470
name: obsolete actomyosin contractile ring assembly involved in mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any actomyosin contractile ring assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "constriction ring assembly involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin contractile ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "cytokinesis, actomyosin ring biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "cytokinesis, actomyosin ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "cytokinesis, contractile ring assembly involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903471
name: regulation of mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic actomyosin contractile ring constriction" EXACT [GOC:vw]
is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
relationship: regulates GO:1902404 ! mitotic actomyosin contractile ring contraction

[Term]
id: GO:1903472
name: negative regulation of mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "down regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie]
synonym: "negative regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic actomyosin contractile ring constriction" EXACT [GOC:vw]
is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process
is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction
relationship: negatively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction

[Term]
id: GO:1903473
name: positive regulation of mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "activation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie]
synonym: "positive regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic actomyosin contractile ring constriction" EXACT [GOC:vw]
synonym: "up regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction
relationship: positively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction

[Term]
id: GO:1903474
name: obsolete anchoring of the mitotic actomyosin contractile ring to the plasma membrane
namespace: biological_process
def: "OBSOLETE. A process that maintains the mitotic actinomyosin contractile ring at the plasma membrane." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:19139265, PMID:28784611]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903475
name: mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0000915 ! actomyosin contractile ring assembly
is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis

[Term]
id: GO:1903476
name: protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any protein localization to cell division site that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "protein localisation to cell division site involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localization to cell division site involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "protein localization to cell division site involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:1902575 ! protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly

[Term]
id: GO:1903477
name: mitotic contractile ring actin filament bundle assembly
namespace: biological_process
def: "Any actin filament bundle assembly that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]
synonym: "actin filament bundle assembly involved in mitotic actomyosin contractile ring assembly" EXACT []
is_a: GO:0071519 ! actomyosin contractile ring actin filament bundle assembly
is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization

[Term]
id: GO:1903478
name: obsolete actin filament bundle convergence involved in mitotic contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "actin filament bundle convergence involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "actin filament bundle convergence involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "actin filament bundle convergence involved in cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "actin filament bundle convergence involved in mitotic actomyosin contractile ring assembly" EXACT []
is_obsolete: true

[Term]
id: GO:1903479
name: mitotic actomyosin contractile ring assembly actin filament organization
namespace: biological_process
def: "Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT []
is_a: GO:1903047 ! mitotic cell cycle process
is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization
relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly

[Term]
id: GO:1903480
name: obsolete regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903481
name: obsolete negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "down regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "inhibition of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903482
name: obsolete positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "activation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "activation of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903483
name: obsolete regulation of maintenance of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903484
name: obsolete negative regulation of maintenance of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "down regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "inhibition of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903485
name: obsolete positive regulation of maintenance of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "activation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "activation of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903486
name: obsolete establishment of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any establishment of actomyosin contractile ring localization that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
is_obsolete: true
replaced_by: GO:1902408

[Term]
id: GO:1903487
name: regulation of lactation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0007595 ! lactation

[Term]
id: GO:1903488
name: negative regulation of lactation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]
synonym: "down regulation of lactation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactation" EXACT [GOC:TermGenie]
synonym: "downregulation of lactation" EXACT [GOC:TermGenie]
synonym: "inhibition of lactation" NARROW [GOC:TermGenie]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903487 ! regulation of lactation
relationship: negatively_regulates GO:0007595 ! lactation

[Term]
id: GO:1903489
name: positive regulation of lactation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]
synonym: "activation of lactation" NARROW [GOC:TermGenie]
synonym: "up regulation of lactation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactation" EXACT [GOC:TermGenie]
synonym: "upregulation of lactation" EXACT [GOC:TermGenie]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903487 ! regulation of lactation
relationship: positively_regulates GO:0007595 ! lactation

[Term]
id: GO:1903490
name: positive regulation of mitotic cytokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:24920823]
synonym: "activation of cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "activation of mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:1902412 ! regulation of mitotic cytokinesis
relationship: positively_regulates GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:1903491
name: response to simvastatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23100282]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0036273 ! response to statin

[Term]
id: GO:1903492
name: response to acetylsalicylate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity." [GO_REF:0000071, GOC:TermGenie, PMID:23392654]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903493
name: response to clopidogrel
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease." [GO_REF:0000071, GOC:TermGenie, PMID:23392654]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903494
name: response to dehydroepiandrosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1903495
name: cellular response to dehydroepiandrosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1903494 ! response to dehydroepiandrosterone

[Term]
id: GO:1903496
name: response to 11-deoxycorticosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1903497
name: cellular response to 11-deoxycorticosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1903496 ! response to 11-deoxycorticosterone

[Term]
id: GO:1903498
name: bundle sheath cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a bundle sheath cell." [GO_REF:0000086, GOC:tb, GOC:TermGenie, PMID:24517883]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:1903499
name: regulation of mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]
synonym: "regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly
relationship: regulates GO:1903475 ! mitotic actomyosin contractile ring assembly

[Term]
id: GO:1903500
name: negative regulation of mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]
synonym: "down regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process
is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly
is_a: GO:2000432 ! negative regulation of cytokinesis, actomyosin contractile ring assembly
relationship: negatively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly

[Term]
id: GO:1903501
name: positive regulation of mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]
synonym: "activation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "activation of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
synonym: "up regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly
is_a: GO:2000433 ! positive regulation of cytokinesis, actomyosin contractile ring assembly
relationship: positively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly

[Term]
id: GO:1903502
name: translation repressor complex
namespace: cellular_component
def: "A protein complex which is capable of translation repressor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:14723848]
comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction).
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1903503
name: ATPase inhibitor complex
namespace: cellular_component
def: "A protein complex which is capable of ATPase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16170325]
comment: An example of this is Mago in drome (P49028) in PMID:16170325 (inferred from direct assay).
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1903504
name: regulation of mitotic spindle checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:23442800]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent).
subset: gocheck_do_not_annotate
synonym: "regulation of mitotic cell cycle spindle checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0090231 ! regulation of spindle checkpoint
relationship: regulates GO:0071174 ! mitotic spindle checkpoint signaling

[Term]
id: GO:1903505
name: obsolete regulation of establishment of actomyosin contractile ring localization involved in mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of establishment of actomyosin contractile ring localization involved in mitotic cell cycle." [GO_REF:0000058, GOC:TermGenie, PMID:24165938]
comment: The reason for obsoletion is that the term is represented in another branch (merge)
is_obsolete: true
replaced_by: GO:1902472

[Term]
id: GO:1903506
name: obsolete regulation of nucleic acid-templated transcription
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]
comment: This term was obsoleted because it represents an unnecessary grouping class.
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:1903507
name: obsolete negative regulation of nucleic acid-templated transcription
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "down regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "down-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "downregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "inhibition of nucleic acid-templated transcription" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:1903508
name: obsolete positive regulation of nucleic acid-templated transcription
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "activation of nucleic acid-templated transcription" NARROW [GOC:TermGenie]
synonym: "up regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0045944

[Term]
id: GO:1903509
name: liposaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving liposaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:9452964]
synonym: "liposaccharide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:1903510
name: mucopolysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucopolysaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:4236091]
synonym: "mucopolysaccharide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:1903511
name: orotic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving orotic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:10727948]
synonym: "orotic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:1903512
name: phytanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytanic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:16799769]
synonym: "phytanic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0097089 ! methyl-branched fatty acid metabolic process

[Term]
id: GO:1903513
name: endoplasmic reticulum to cytosol transport
namespace: biological_process
def: "The directed movement of substances from endoplasmic reticulum to cytosol." [GO_REF:0000076, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]
synonym: "ER to cytosol transport" EXACT [GOC:TermGenie]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:1903514
name: release of sequestered calcium ion into cytosol by endoplasmic reticulum
namespace: biological_process
def: "The directed movement of calcium ion from endoplasmic reticulum to cytosol." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]
synonym: "calcium ion transport from endoplasmic reticulum to cytosol" BROAD []
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:1903515
name: calcium ion transport from cytosol to endoplasmic reticulum
namespace: biological_process
def: "The directed movement of calcium ion from cytosol to endoplasmic reticulum." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]
is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport
is_a: GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:1903516
name: regulation of single strand break repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0000012 ! single strand break repair

[Term]
id: GO:1903517
name: negative regulation of single strand break repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]
synonym: "down regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "inhibition of single strand break repair" NARROW [GOC:TermGenie]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:1903516 ! regulation of single strand break repair
relationship: negatively_regulates GO:0000012 ! single strand break repair

[Term]
id: GO:1903518
name: positive regulation of single strand break repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]
synonym: "activation of single strand break repair" NARROW [GOC:TermGenie]
synonym: "up regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "upregulation of single strand break repair" EXACT [GOC:TermGenie]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:1903516 ! regulation of single strand break repair
relationship: positively_regulates GO:0000012 ! single strand break repair

[Term]
id: GO:1903519
name: regulation of mammary gland involution
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0060056 ! mammary gland involution

[Term]
id: GO:1903520
name: negative regulation of mammary gland involution
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]
synonym: "down regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "down-regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "downregulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "inhibition of mammary gland involution" NARROW [GOC:TermGenie]
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:1903519 ! regulation of mammary gland involution
relationship: negatively_regulates GO:0060056 ! mammary gland involution

[Term]
id: GO:1903521
name: positive regulation of mammary gland involution
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]
synonym: "activation of mammary gland involution" NARROW [GOC:TermGenie]
synonym: "up regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "up-regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "upregulation of mammary gland involution" EXACT [GOC:TermGenie]
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:1903519 ! regulation of mammary gland involution
relationship: positively_regulates GO:0060056 ! mammary gland involution

[Term]
id: GO:1903522
name: regulation of blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0008015 ! blood circulation

[Term]
id: GO:1903523
name: negative regulation of blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
relationship: negatively_regulates GO:0008015 ! blood circulation

[Term]
id: GO:1903524
name: positive regulation of blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "activation of blood circulation" NARROW [GOC:TermGenie]
synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
relationship: positively_regulates GO:0008015 ! blood circulation

[Term]
id: GO:1903525
name: regulation of membrane tubulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]
synonym: "regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "regulation of vesicle scission" RELATED [GOC:TermGenie]
is_a: GO:1903729 ! regulation of plasma membrane organization
relationship: regulates GO:0097320 ! plasma membrane tubulation

[Term]
id: GO:1903526
name: negative regulation of membrane tubulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]
synonym: "down regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "down regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane tubulation" NARROW [GOC:TermGenie]
synonym: "inhibition of plasma membrane tubulation" NARROW [GOC:TermGenie]
synonym: "negative regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903525 ! regulation of membrane tubulation
relationship: negatively_regulates GO:0097320 ! plasma membrane tubulation

[Term]
id: GO:1903527
name: positive regulation of membrane tubulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]
synonym: "activation of membrane tubulation" NARROW [GOC:TermGenie]
synonym: "activation of plasma membrane tubulation" NARROW [GOC:TermGenie]
synonym: "positive regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903525 ! regulation of membrane tubulation
relationship: positively_regulates GO:0097320 ! plasma membrane tubulation

[Term]
id: GO:1903528
name: regulation of dCDP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005]
synonym: "regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "regulation of dCDP synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
relationship: regulates GO:0006240 ! dCDP biosynthetic process

[Term]
id: GO:1903529
name: negative regulation of dCDP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005]
synonym: "down regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dCDP anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP formation" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of dCDP synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900398 ! negative regulation of pyrimidine nucleotide biosynthetic process
is_a: GO:1903528 ! regulation of dCDP biosynthetic process
relationship: negatively_regulates GO:0006240 ! dCDP biosynthetic process

[Term]
id: GO:1903530
name: regulation of secretion by cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0032940 ! secretion by cell

[Term]
id: GO:1903531
name: negative regulation of secretion by cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
relationship: negatively_regulates GO:0032940 ! secretion by cell

[Term]
id: GO:1903532
name: positive regulation of secretion by cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "activation of cellular secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion by cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
relationship: positively_regulates GO:0032940 ! secretion by cell

[Term]
id: GO:1903533
name: regulation of protein targeting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting." [GO_REF:0000058, GOC:TermGenie]
synonym: "regulation of nascent polypeptide association" RELATED [GOC:TermGenie]
synonym: "regulation of protein sorting along secretory pathway" NARROW [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
relationship: regulates GO:0006605 ! protein targeting

[Term]
id: GO:1903534
name: regulation of lactose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]
synonym: "regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "regulation of lactose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0005989 ! lactose biosynthetic process

[Term]
id: GO:1903535
name: negative regulation of lactose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]
synonym: "down regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of lactose anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose formation" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of lactose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1903534 ! regulation of lactose biosynthetic process
relationship: negatively_regulates GO:0005989 ! lactose biosynthetic process

[Term]
id: GO:1903536
name: positive regulation of lactose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]
synonym: "activation of lactose anabolism" NARROW [GOC:TermGenie]
synonym: "activation of lactose biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of lactose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of lactose formation" NARROW [GOC:TermGenie]
synonym: "activation of lactose synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1903534 ! regulation of lactose biosynthetic process
relationship: positively_regulates GO:0005989 ! lactose biosynthetic process

[Term]
id: GO:1903537
name: meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "meiosis involved in oocyte maturation" BROAD []
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0001556 ! oocyte maturation

[Term]
id: GO:1903538
name: regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation

[Term]
id: GO:1903539
name: protein localization to postsynaptic membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322]
synonym: "protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in postsynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0062237 ! protein localization to postsynapse
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1903540
name: establishment of protein localization to postsynaptic membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322]
synonym: "establishment of protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localization in postsynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:1903539 ! protein localization to postsynaptic membrane

[Term]
id: GO:1903541
name: regulation of exosomal secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0017157 ! regulation of exocytosis
relationship: regulates GO:1990182 ! exosomal secretion

[Term]
id: GO:1903542
name: negative regulation of exosomal secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
relationship: negatively_regulates GO:1990182 ! exosomal secretion

[Term]
id: GO:1903543
name: positive regulation of exosomal secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
relationship: positively_regulates GO:1990182 ! exosomal secretion

[Term]
id: GO:1903544
name: response to butyrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:1903545
name: cellular response to butyrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:1903544 ! response to butyrate

[Term]
id: GO:1903546
name: protein localization to photoreceptor outer segment
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment." [GO_REF:0000087, GOC:TermGenie, PMID:11481257, PMID:21867699]
synonym: "protein localisation in photoreceptor outer segment" EXACT [GOC:TermGenie]
synonym: "protein localisation to photoreceptor outer segment" EXACT [GOC:TermGenie]
synonym: "protein localization in photoreceptor outer segment" EXACT [GOC:TermGenie]
is_a: GO:0097499 ! protein localization to non-motile cilium

[Term]
id: GO:1903547
name: regulation of growth hormone activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]
subset: gocheck_obsoletion_candidate
synonym: "regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:1903548
name: obsolete negative regulation of growth hormone activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "down regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "down regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "downregulation of GH activity" EXACT [GOC:TermGenie]
synonym: "downregulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "downregulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GH activity" NARROW [GOC:TermGenie]
synonym: "inhibition of growth hormone activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "inhibition of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903549
name: obsolete positive regulation of growth hormone activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of GH activity" NARROW [GOC:TermGenie]
synonym: "activation of growth hormone activity" NARROW [GOC:TermGenie]
synonym: "activation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "activation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "up regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "upregulation of GH activity" EXACT [GOC:TermGenie]
synonym: "upregulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "upregulation of placental growth hormone activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903551
name: regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0071971 ! extracellular exosome assembly

[Term]
id: GO:1903552
name: negative regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
relationship: negatively_regulates GO:0071971 ! extracellular exosome assembly

[Term]
id: GO:1903553
name: positive regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles]
synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
relationship: positively_regulates GO:0071971 ! extracellular exosome assembly

[Term]
id: GO:1903554
name: G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway that is involved in the defense response to Gram-negative bacterium." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:25303524]
synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium

[Term]
id: GO:1903555
name: regulation of tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:1903556
name: negative regulation of tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "down regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "down regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "down regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "down-regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "down-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "down-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "downregulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "downregulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "downregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "inhibition of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "inhibition of TNFSF cytokine production" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie]
synonym: "negative regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "negative regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
relationship: negatively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:1903557
name: positive regulation of tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "activation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "activation of TNFSF cytokine production" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie]
synonym: "positive regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "positive regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "up regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "up regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "up-regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "up-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "upregulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "upregulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
relationship: positively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:1903558
name: 3-cyano-L-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, PMID:24100226, PMID:24843024]
synonym: "3-cyano-L-alanine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0033052 ! cyanoamino acid metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process

[Term]
id: GO:1903559
name: 3-cyano-L-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, PMID:24100226, PMID:24843024]
synonym: "3-cyano-L-alanine breakdown" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine catabolism" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine degradation" EXACT [GOC:TermGenie]
is_a: GO:0050899 ! nitrile catabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process

[Term]
id: GO:1903560
name: 3-cyano-L-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, PMID:24100226, PMID:24843024]
synonym: "3-cyano-L-alanine anabolism" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine formation" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0080028 ! nitrile biosynthetic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process

[Term]
id: GO:1903561
name: extracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]
synonym: "microparticle" RELATED [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0065010 ! extracellular membrane-bounded organelle

[Term]
id: GO:1903562
name: microtubule bundle formation involved in mitotic spindle midzone assembly
namespace: biological_process
def: "Any microtubule bundle formation that is involved in spindle midzone assembly involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:15647375]
synonym: "microtubule bundle formation involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie]
synonym: "microtubule bundle formation involved in spindle midzone assembly involved in mitosis" EXACT [GOC:dos]
synonym: "microtubule bundling involved in mitotic spindle midzone assembly" RELATED [GOC:TermGenie]
synonym: "microtubule bundling involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in spindle midzone assembly involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in spindle midzone biogenesis involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in spindle midzone formation involved in mitosis" EXACT [GOC:TermGenie]
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis
relationship: part_of GO:0051256 ! mitotic spindle midzone assembly

[Term]
id: GO:1903563
name: microtubule bundle formation involved in horsetail-astral microtubule organization
namespace: biological_process
def: "Any microtubule bundle formation that is involved in horsetail-astral microtubule organization." [GO_REF:0000060, GOC:TermGenie, PMID:15647375]
synonym: "microtubule bundle formation involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie]
synonym: "microtubule bundle formation involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in horsetail-astral microtubule organization" EXACT [GOC:TermGenie]
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0032118 ! horsetail-astral microtubule organization

[Term]
id: GO:1903564
name: regulation of protein localization to cilium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0061512 ! protein localization to cilium

[Term]
id: GO:1903565
name: negative regulation of protein localization to cilium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:0061512 ! protein localization to cilium

[Term]
id: GO:1903566
name: positive regulation of protein localization to cilium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:0061512 ! protein localization to cilium

[Term]
id: GO:1903567
name: regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:1903441 ! protein localization to ciliary membrane

[Term]
id: GO:1903568
name: negative regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903565 ! negative regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1905476 ! negative regulation of protein localization to membrane
relationship: negatively_regulates GO:1903441 ! protein localization to ciliary membrane

[Term]
id: GO:1903569
name: positive regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903566 ! positive regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1905477 ! positive regulation of protein localization to membrane
relationship: positively_regulates GO:1903441 ! protein localization to ciliary membrane

[Term]
id: GO:1903570
name: obsolete regulation of protein kinase D signaling
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
comment: This term was obsoleted because protein kinase D activity is part of other signaling pathways, it is not itself a signaling pathway.
synonym: "regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903571
name: obsolete negative regulation of protein kinase D signaling
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
comment: This term was obsoleted because protein kinase D activity is part of other signaling pathways, it is not itself a signaling pathway.
synonym: "down regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of PKD signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of protein kinase D signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein kinase D signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903572
name: obsolete positive regulation of protein kinase D signaling
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
comment: This term was obsoleted because protein kinase D activity is part of other signaling pathways, it is not itself a signaling pathway.
synonym: "activation of PKD signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of protein kinase D signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of protein kinase D signaling" NARROW [GOC:TermGenie]
synonym: "activation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903573
name: negative regulation of response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
synonym: "down regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "down regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "downregulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of ER stress response" NARROW [GOC:TermGenie]
synonym: "inhibition of response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of response to ER stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ER stress" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress
relationship: negatively_regulates GO:0034976 ! response to endoplasmic reticulum stress

[Term]
id: GO:1903574
name: negative regulation of cellular response to amino acid starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
synonym: "down regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to amino acid starvation" NARROW [GOC:TermGenie]
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903832 ! regulation of cellular response to amino acid starvation
relationship: negatively_regulates GO:0034198 ! cellular response to amino acid starvation

[Term]
id: GO:1903575
name: cornified envelope assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cornified envelope." [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495]
comment: An example of this is syntaxin 4 in PMID:22226963.
synonym: "cornified envelope formation" EXACT [GOC:TermGenie]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0071709 ! membrane assembly

[Term]
id: GO:1903576
name: response to L-arginine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903577
name: cellular response to L-arginine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903576 ! response to L-arginine

[Term]
id: GO:1903578
name: regulation of ATP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]
synonym: "regulation of ATP metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
relationship: regulates GO:0046034 ! ATP metabolic process

[Term]
id: GO:1903579
name: negative regulation of ATP metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]
synonym: "down regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
relationship: negatively_regulates GO:0046034 ! ATP metabolic process

[Term]
id: GO:1903580
name: positive regulation of ATP metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]
synonym: "activation of ATP metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ATP metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
relationship: positively_regulates GO:0046034 ! ATP metabolic process

[Term]
id: GO:1903581
name: regulation of basophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837]
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002561 ! basophil degranulation

[Term]
id: GO:1903582
name: negative regulation of basophil degranulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837]
synonym: "down regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "downregulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "inhibition of basophil degranulation" NARROW [GOC:TermGenie]
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:1903581 ! regulation of basophil degranulation
relationship: negatively_regulates GO:0002561 ! basophil degranulation

[Term]
id: GO:1903583
name: positive regulation of basophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837]
synonym: "activation of basophil degranulation" NARROW [GOC:TermGenie]
synonym: "up regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "upregulation of basophil degranulation" EXACT [GOC:TermGenie]
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:1903581 ! regulation of basophil degranulation
relationship: positively_regulates GO:0002561 ! basophil degranulation

[Term]
id: GO:1903584
name: obsolete regulation of histone deubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, PMID:24526689]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903585
name: obsolete negative regulation of histone deubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, PMID:24526689]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone deubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of histone deubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone deubiquitylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903586
name: obsolete positive regulation of histone deubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, PMID:24526689]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone deubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of histone deubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of histone deubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deubiquitylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903587
name: regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056]
synonym: "regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
is_a: GO:0001936 ! regulation of endothelial cell proliferation
relationship: regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis

[Term]
id: GO:1903588
name: negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056]
synonym: "down regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
is_a: GO:0001937 ! negative regulation of endothelial cell proliferation
is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
relationship: negatively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis

[Term]
id: GO:1903589
name: positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056]
synonym: "activation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "activation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
is_a: GO:0001938 ! positive regulation of endothelial cell proliferation
is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
relationship: positively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis

[Term]
id: GO:1903590
name: regulation of lysozyme activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:1903591
name: obsolete negative regulation of lysozyme activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "down regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "down regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "down regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "down regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "down-regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "down-regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "down-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "downregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of globulin G" RELATED [GOC:TermGenie]
synonym: "downregulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "downregulation of L-7001" RELATED [GOC:TermGenie]
synonym: "downregulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "downregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "inhibition of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of globulin G" RELATED [GOC:TermGenie]
synonym: "inhibition of globulin G1" RELATED [GOC:TermGenie]
synonym: "inhibition of L-7001" RELATED [GOC:TermGenie]
synonym: "inhibition of lysozyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lysozyme g" RELATED [GOC:TermGenie]
synonym: "inhibition of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of muramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "negative regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "negative regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "negative regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "negative regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903592
name: positive regulation of lysozyme activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]
subset: gocheck_obsoletion_candidate
synonym: "activation of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of globulin G" RELATED [GOC:TermGenie]
synonym: "activation of globulin G1" RELATED [GOC:TermGenie]
synonym: "activation of L-7001" RELATED [GOC:TermGenie]
synonym: "activation of lysozyme activity" NARROW [GOC:TermGenie]
synonym: "activation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "activation of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of muramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "positive regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "positive regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "positive regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "positive regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "up regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "up regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "up regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "up regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "up regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "up regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "up-regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "up-regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "up-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "upregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of globulin G" RELATED [GOC:TermGenie]
synonym: "upregulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "upregulation of L-7001" RELATED [GOC:TermGenie]
synonym: "upregulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "upregulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "upregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PR1-lysozyme" RELATED [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1903590 ! regulation of lysozyme activity

[Term]
id: GO:1903593
name: regulation of histamine secretion by mast cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0002553 ! histamine secretion by mast cell

[Term]
id: GO:1903594
name: negative regulation of histamine secretion by mast cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]
synonym: "down regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "downregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "inhibition of histamine secretion by mast cell" NARROW [GOC:TermGenie]
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:1903593 ! regulation of histamine secretion by mast cell
relationship: negatively_regulates GO:0002553 ! histamine secretion by mast cell

[Term]
id: GO:1903595
name: positive regulation of histamine secretion by mast cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]
synonym: "activation of histamine secretion by mast cell" NARROW [GOC:TermGenie]
synonym: "up regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "upregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
is_a: GO:0043306 ! positive regulation of mast cell degranulation
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903593 ! regulation of histamine secretion by mast cell
relationship: positively_regulates GO:0002553 ! histamine secretion by mast cell

[Term]
id: GO:1903596
name: regulation of gap junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]
is_a: GO:1901888 ! regulation of cell junction assembly
relationship: regulates GO:0016264 ! gap junction assembly

[Term]
id: GO:1903597
name: negative regulation of gap junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]
synonym: "down regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of gap junction assembly" NARROW [GOC:TermGenie]
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:1903596 ! regulation of gap junction assembly
relationship: negatively_regulates GO:0016264 ! gap junction assembly

[Term]
id: GO:1903598
name: positive regulation of gap junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]
synonym: "activation of gap junction assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of gap junction assembly" EXACT [GOC:TermGenie]
is_a: GO:1901890 ! positive regulation of cell junction assembly
is_a: GO:1903596 ! regulation of gap junction assembly
relationship: positively_regulates GO:0016264 ! gap junction assembly

[Term]
id: GO:1903599
name: positive regulation of autophagy of mitochondrion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002]
comment: An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay
synonym: "activation of mitochondrion degradation" RELATED [GOC:TermGenie]
synonym: "activation of mitophagy" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial degradation" BROAD [GOC:TermGenie]
synonym: "up regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "up regulation of mitophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "up-regulation of mitophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "upregulation of mitophagy" EXACT [GOC:TermGenie]
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:1903146 ! regulation of autophagy of mitochondrion
relationship: positively_regulates GO:0000422 ! autophagy of mitochondrion

[Term]
id: GO:1903600
name: glutaminase complex
namespace: cellular_component
def: "A protein complex which is capable of glutaminase activity." [GO_REF:0000088, GOC:TermGenie, PMID:14764090]
synonym: "Sno1p-Snz1p" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1903601
name: thermospermine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355]
synonym: "thermospermine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:1903602
name: thermospermine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355]
synonym: "thermospermine breakdown" EXACT [GOC:TermGenie]
synonym: "thermospermine catabolism" EXACT [GOC:TermGenie]
synonym: "thermospermine degradation" EXACT [GOC:TermGenie]
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:1903601 ! thermospermine metabolic process

[Term]
id: GO:1903603
name: thermospermine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355]
synonym: "thermospermine anabolism" EXACT [GOC:TermGenie]
synonym: "thermospermine biosynthesis" EXACT [GOC:TermGenie]
synonym: "thermospermine formation" EXACT [GOC:TermGenie]
synonym: "thermospermine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:1903601 ! thermospermine metabolic process

[Term]
id: GO:1903604
name: cytochrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:1903605
name: cytochrome biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome anabolism" EXACT [GOC:TermGenie]
synonym: "cytochrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "cytochrome formation" EXACT [GOC:TermGenie]
synonym: "cytochrome synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1903604 ! cytochrome metabolic process

[Term]
id: GO:1903606
name: cytochrome c metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome c metabolism" EXACT [GOC:TermGenie]
is_a: GO:1903604 ! cytochrome metabolic process

[Term]
id: GO:1903607
name: cytochrome c biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome c anabolism" EXACT [GOC:TermGenie]
synonym: "cytochrome c biosynthesis" EXACT [GOC:TermGenie]
synonym: "cytochrome c formation" EXACT [GOC:TermGenie]
synonym: "cytochrome c synthesis" EXACT [GOC:TermGenie]
is_a: GO:1903605 ! cytochrome biosynthetic process
is_a: GO:1903606 ! cytochrome c metabolic process

[Term]
id: GO:1903608
name: protein localization to cytoplasmic stress granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092]
synonym: "protein localisation in cytoplasmic stress granule" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytoplasmic stress granule" EXACT [GOC:TermGenie]
synonym: "protein localization in cytoplasmic stress granule" EXACT [GOC:TermGenie]
synonym: "protein localization to stress granule" BROAD []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:1903609
name: negative regulation of inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18923542]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Kir channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Kir channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity
is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity

[Term]
id: GO:1903610
name: regulation of calcium-dependent ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851]
subset: gocheck_obsoletion_candidate
is_a: GO:0043462 ! regulation of ATP-dependent activity

[Term]
id: GO:1903611
name: negative regulation of calcium-dependent ATPase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium-dependent ATPase activity" NARROW [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATP-dependent activity
is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity

[Term]
id: GO:1903612
name: positive regulation of calcium-dependent ATPase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851]
subset: gocheck_obsoletion_candidate
synonym: "activation of calcium-dependent ATPase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATP-dependent activity
is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity

[Term]
id: GO:1903613
name: obsolete regulation of protein tyrosine phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903614
name: obsolete negative regulation of protein tyrosine phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "down regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PPT-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PTP-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PTPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903615
name: obsolete positive regulation of protein tyrosine phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "activation of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of PPT-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of PTP-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of PTPase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903616
name: obsolete MAPK cascade involved in axon regeneration
namespace: biological_process
def: "OBSOLETE. Any MAPK cascade that is involved in axon regeneration." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19164707, PMID:19417215, PMID:19737525]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903617
name: positive regulation of mitotic cytokinesis, division site positioning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis, division site positioning." [PMID:21246752, PMID:9852154]
synonym: "positive regulation of mitotic cytokinesis, site selection" EXACT []
is_a: GO:1902472 ! regulation of mitotic cytokinesis, division site positioning
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:2000076 ! positive regulation of cytokinesis, site selection
relationship: positively_regulates GO:1902408 ! mitotic cytokinesis, division site positioning

[Term]
id: GO:1903618
name: regulation of transdifferentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0060290 ! transdifferentiation

[Term]
id: GO:1903619
name: negative regulation of transdifferentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091]
synonym: "down regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of transdifferentiation" NARROW [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903618 ! regulation of transdifferentiation
relationship: negatively_regulates GO:0060290 ! transdifferentiation

[Term]
id: GO:1903620
name: positive regulation of transdifferentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091]
synonym: "activation of transdifferentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of transdifferentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903618 ! regulation of transdifferentiation
relationship: positively_regulates GO:0060290 ! transdifferentiation

[Term]
id: GO:1903621
name: protein localization to photoreceptor connecting cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor connecting cilium." [GO_REF:0000087, GOC:lb, GOC:TermGenie, PMID:25398945]
synonym: "protein localisation in photoreceptor connecting cilium" EXACT [GOC:TermGenie]
synonym: "protein localisation to photoreceptor connecting cilium" EXACT [GOC:TermGenie]
synonym: "protein localization in photoreceptor connecting cilium" EXACT [GOC:TermGenie]
is_a: GO:0097499 ! protein localization to non-motile cilium
is_a: GO:1904491 ! protein localization to ciliary transition zone

[Term]
id: GO:1903622
name: regulation of RNA polymerase III activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932]
subset: gocheck_obsoletion_candidate
synonym: "regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
is_a: GO:0006359 ! regulation of transcription by RNA polymerase III
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1903623
name: negative regulation of RNA polymerase III activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA polymerase III activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase III activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase III activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA polymerase III activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
is_a: GO:0016480 ! negative regulation of transcription by RNA polymerase III
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1903622 ! regulation of RNA polymerase III activity

[Term]
id: GO:1903624
name: regulation of DNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006308 ! DNA catabolic process

[Term]
id: GO:1903625
name: negative regulation of DNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
relationship: negatively_regulates GO:0006308 ! DNA catabolic process

[Term]
id: GO:1903626
name: positive regulation of DNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "activation of DNA degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
relationship: positively_regulates GO:0006308 ! DNA catabolic process

[Term]
id: GO:1903627
name: obsolete regulation of dUTP diphosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of dUTPase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903628
name: obsolete negative regulation of dUTP diphosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTP diphosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dUTPase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903629
name: obsolete positive regulation of dUTP diphosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTP diphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTPase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903630
name: regulation of aminoacyl-tRNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
subset: gocheck_obsoletion_candidate
synonym: "regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:1903631
name: obsolete negative regulation of aminoacyl-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "downregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "inhibition of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903632
name: obsolete positive regulation of aminoacyl-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "up regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "upregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903633
name: obsolete regulation of leucine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903634
name: obsolete negative regulation of leucine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of leucine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903635
name: obsolete positive regulation of leucine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "activation of leucine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903636
name: regulation of protein insertion into mitochondrial outer membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546]
synonym: "regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "regulation of protein import into mitochondrial outer membrane" EXACT []
synonym: "regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:1903214 ! regulation of protein targeting to mitochondrion
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:0045040 ! protein insertion into mitochondrial outer membrane

[Term]
id: GO:1903637
name: negative regulation of protein insertion into mitochondrial outer membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein insertion into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546]
synonym: "down regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "down regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "downregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie]
synonym: "inhibition of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein import into mitochondrial outer membrane" EXACT []
synonym: "negative regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1903215 ! negative regulation of protein targeting to mitochondrion
is_a: GO:1903636 ! regulation of protein insertion into mitochondrial outer membrane
is_a: GO:1905476 ! negative regulation of protein localization to membrane
relationship: negatively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane

[Term]
id: GO:1903638
name: positive regulation of protein insertion into mitochondrial outer membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546]
synonym: "activation of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie]
synonym: "activation of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein import into mitochondrial outer membrane" EXACT []
synonym: "positive regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "up regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "upregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903636 ! regulation of protein insertion into mitochondrial outer membrane
is_a: GO:1903955 ! positive regulation of protein targeting to mitochondrion
is_a: GO:1905477 ! positive regulation of protein localization to membrane
relationship: positively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane

[Term]
id: GO:1903639
name: regulation of gastrin-induced gastric acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201]
is_a: GO:0060453 ! regulation of gastric acid secretion
relationship: regulates GO:0001698 ! gastrin-induced gastric acid secretion

[Term]
id: GO:1903640
name: negative regulation of gastrin-induced gastric acid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201]
synonym: "down regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie]
is_a: GO:0060455 ! negative regulation of gastric acid secretion
is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion
relationship: negatively_regulates GO:0001698 ! gastrin-induced gastric acid secretion

[Term]
id: GO:1903641
name: positive regulation of gastrin-induced gastric acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201]
synonym: "activation of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
is_a: GO:0060454 ! positive regulation of gastric acid secretion
is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion
relationship: positively_regulates GO:0001698 ! gastrin-induced gastric acid secretion

[Term]
id: GO:1903642
name: regulation of recombination hotspot binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749]
subset: gocheck_do_not_annotate
synonym: "regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:1903643
name: positive regulation of recombination hotspot binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749]
subset: gocheck_do_not_annotate
synonym: "activation of DNA binding, recombination hotspot" NARROW [GOC:TermGenie]
synonym: "activation of recombination hotspot binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up regulation of recombination hotspot binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up-regulation of recombination hotspot binding" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "upregulation of recombination hotspot binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1903642 ! regulation of recombination hotspot binding

[Term]
id: GO:1903644
name: regulation of chaperone-mediated protein folding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]
is_a: GO:1903332 ! regulation of protein folding
relationship: regulates GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:1903645
name: negative regulation of chaperone-mediated protein folding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]
synonym: "down regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "down-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "downregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "inhibition of chaperone-mediated protein folding" NARROW [GOC:TermGenie]
is_a: GO:1903333 ! negative regulation of protein folding
is_a: GO:1903644 ! regulation of chaperone-mediated protein folding
relationship: negatively_regulates GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:1903646
name: positive regulation of chaperone-mediated protein folding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]
synonym: "activation of chaperone-mediated protein folding" NARROW [GOC:TermGenie]
synonym: "up regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "up-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "upregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
is_a: GO:1903334 ! positive regulation of protein folding
is_a: GO:1903644 ! regulation of chaperone-mediated protein folding
relationship: positively_regulates GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:1903647
name: negative regulation of chlorophyll catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469]
synonym: "down regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of chlorophyll breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
is_a: GO:0010271 ! regulation of chlorophyll catabolic process
is_a: GO:1901405 ! negative regulation of tetrapyrrole catabolic process
relationship: negatively_regulates GO:0015996 ! chlorophyll catabolic process

[Term]
id: GO:1903648
name: positive regulation of chlorophyll catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469]
synonym: "activation of chlorophyll breakdown" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll catabolism" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll degradation" EXACT [GOC:TermGenie]
is_a: GO:0010271 ! regulation of chlorophyll catabolic process
is_a: GO:1901406 ! positive regulation of tetrapyrrole catabolic process
relationship: positively_regulates GO:0015996 ! chlorophyll catabolic process

[Term]
id: GO:1903649
name: obsolete regulation of cytoplasmic transport
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903650
name: obsolete negative regulation of cytoplasmic transport
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "down regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "down regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "downregulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "inhibition of cytoplasmic transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903651
name: obsolete positive regulation of cytoplasmic transport
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
synonym: "activation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "activation of cytoplasmic transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "upregulation of cytoplasmic transport" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903652
name: obsolete modulation by virus of host cytoplasmic transport
namespace: biological_process
def: "OBSOLETE. Modulation by an infecting virus of host cytoplasmic transport." [GO_REF:0000063, GOC:TermGenie, PMID:25049409]
comment: This term was obsoleted because it represents the same process as symbiont-mediated perturbation of host intracellular transport ; GO:0052038.
synonym: "regulation by virus of host cytoplasmic streaming" EXACT []
synonym: "regulation by virus of host cytoplasmic transport" EXACT []
synonym: "viral modulation of host cytoplasmic trafficking" EXACT []
is_obsolete: true
replaced_by: GO:0052038

[Term]
id: GO:1903653
name: symbiont-mediated perturbation of host cell motility
namespace: biological_process
def: "A process in which a symbiont alters or subverts cell motility in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GO_REF:0000063, GOC:TermGenie, PMID:25049409]
synonym: "modulation by symbiont of host cell locomotion" EXACT []
synonym: "modulation by symbiont of host cell motility" EXACT []
synonym: "modulation by symbiont of host cell movement" RELATED []
synonym: "regulation by symbiont of host cell motility" EXACT []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:1903654
name: obsolete phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067]
comment: This term was obsoleted because it represents both a molecular function and a biological process.
is_obsolete: true
consider: GO:0006368
consider: GO:0140836

[Term]
id: GO:1903655
name: obsolete phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any phosphorylation of RNA polymerase II C-terminal domain serine 2 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067]
comment: This term was obsoleted because it represents both a molecular function and a biological process.
is_obsolete: true
consider: GO:0006368
consider: GO:0140834

[Term]
id: GO:1903656
name: regulation of type IV pilus biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0060491 ! regulation of cell projection assembly
relationship: regulates GO:0043683 ! type IV pilus assembly

[Term]
id: GO:1903657
name: negative regulation of type IV pilus biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "down regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of TFP biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type 4 pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbria assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbria biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbriae assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbriae biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrial assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrial biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrium biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV pilus biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1903656 ! regulation of type IV pilus biogenesis
relationship: negatively_regulates GO:0043683 ! type IV pilus assembly

[Term]
id: GO:1903658
name: positive regulation of type IV pilus biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "activation of TFP biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type 4 pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbria assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbria biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbriae assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbriae biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrial assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrial biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrium assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrium biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV pilus biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:1903656 ! regulation of type IV pilus biogenesis
relationship: positively_regulates GO:0043683 ! type IV pilus assembly

[Term]
id: GO:1903659
name: regulation of complement-dependent cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217]
is_a: GO:0031341 ! regulation of cell killing
relationship: regulates GO:0097278 ! complement-dependent cytotoxicity

[Term]
id: GO:1903660
name: negative regulation of complement-dependent cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217]
synonym: "down regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "down-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "downregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "inhibition of complement-dependent cytotoxicity" NARROW [GOC:TermGenie]
is_a: GO:0031342 ! negative regulation of cell killing
is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity
relationship: negatively_regulates GO:0097278 ! complement-dependent cytotoxicity

[Term]
id: GO:1903661
name: positive regulation of complement-dependent cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217]
synonym: "activation of complement-dependent cytotoxicity" NARROW [GOC:TermGenie]
synonym: "up regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "up-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "upregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
is_a: GO:0031343 ! positive regulation of cell killing
is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity
relationship: positively_regulates GO:0097278 ! complement-dependent cytotoxicity

[Term]
id: GO:1903662
name: L-altrarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980]
synonym: "L-altrarate(1-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0019577 ! aldaric acid metabolic process

[Term]
id: GO:1903663
name: L-altrarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980]
synonym: "L-altrarate(1-) breakdown" EXACT [GOC:TermGenie]
synonym: "L-altrarate(1-) catabolism" EXACT [GOC:TermGenie]
synonym: "L-altrarate(1-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019579 ! aldaric acid catabolic process
is_a: GO:1903662 ! L-altrarate metabolic process

[Term]
id: GO:1903664
name: regulation of asexual reproduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142]
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0019954 ! asexual reproduction

[Term]
id: GO:1903665
name: negative regulation of asexual reproduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142]
synonym: "down regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "downregulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "inhibition of asexual reproduction" NARROW [GOC:TermGenie]
is_a: GO:1903664 ! regulation of asexual reproduction
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0019954 ! asexual reproduction

[Term]
id: GO:1903666
name: positive regulation of asexual reproduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142]
synonym: "activation of asexual reproduction" NARROW [GOC:TermGenie]
synonym: "up regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "upregulation of asexual reproduction" EXACT [GOC:TermGenie]
is_a: GO:1903664 ! regulation of asexual reproduction
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0019954 ! asexual reproduction

[Term]
id: GO:1903667
name: regulation of chemorepellent activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]
subset: gocheck_obsoletion_candidate
synonym: "regulation of chemorepellant activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:0050923 ! regulation of negative chemotaxis
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:1903668
name: obsolete negative regulation of chemorepellent activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "down regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "downregulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "downregulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "inhibition of chemorepellant activity" NARROW [GOC:TermGenie]
synonym: "inhibition of chemorepellent activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of chemorepellant activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903669
name: obsolete positive regulation of chemorepellent activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of chemorepellant activity" NARROW [GOC:TermGenie]
synonym: "activation of chemorepellent activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "up regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "up regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "upregulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "upregulation of chemorepellent activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903670
name: regulation of sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
is_a: GO:0045765 ! regulation of angiogenesis
relationship: regulates GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:1903671
name: negative regulation of sprouting angiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
synonym: "down regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sprouting angiogenesis" NARROW [GOC:TermGenie]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:1903670 ! regulation of sprouting angiogenesis
relationship: negatively_regulates GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:1903672
name: positive regulation of sprouting angiogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
synonym: "activation of sprouting angiogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:1903670 ! regulation of sprouting angiogenesis
relationship: positively_regulates GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:1903673
name: mitotic cleavage furrow formation
namespace: biological_process
def: "Any cleavage furrow formation that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "cleavage furrow positioning involved in mitotic cell cycle" NARROW [GOC:TermGenie]
is_a: GO:0036089 ! cleavage furrow formation
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1903674
name: regulation of cap-dependent translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
relationship: regulates GO:0002191 ! cap-dependent translational initiation

[Term]
id: GO:1903675
name: negative regulation of cap-dependent translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cap-dependent translational initiation" NARROW [GOC:TermGenie]
is_a: GO:1903674 ! regulation of cap-dependent translational initiation
is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation
relationship: negatively_regulates GO:0002191 ! cap-dependent translational initiation

[Term]
id: GO:1903676
name: positive regulation of cap-dependent translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995]
synonym: "activation of cap-dependent translational initiation" NARROW [GOC:TermGenie]
synonym: "up regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
is_a: GO:1903674 ! regulation of cap-dependent translational initiation
is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation
relationship: positively_regulates GO:0002191 ! cap-dependent translational initiation

[Term]
id: GO:1903677
name: regulation of cap-independent translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
relationship: regulates GO:0002190 ! cap-independent translational initiation

[Term]
id: GO:1903678
name: negative regulation of cap-independent translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cap-independent translational initiation" NARROW [GOC:TermGenie]
is_a: GO:1903677 ! regulation of cap-independent translational initiation
is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation
relationship: negatively_regulates GO:0002190 ! cap-independent translational initiation

[Term]
id: GO:1903679
name: positive regulation of cap-independent translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995]
synonym: "activation of cap-independent translational initiation" NARROW [GOC:TermGenie]
synonym: "up regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
is_a: GO:1903677 ! regulation of cap-independent translational initiation
is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation
relationship: positively_regulates GO:0002190 ! cap-independent translational initiation

[Term]
id: GO:1903680
name: acinar cell of sebaceous gland differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an acinar cell of sebaceous gland." [GO_REF:0000086, GOC:TermGenie, PMID:17018284, PMID:18334552, PMID:19944183]
synonym: "sebocyte differentiation" EXACT [CL:0002140]
is_a: GO:0001949 ! sebaceous gland cell differentiation
is_a: GO:0090425 ! acinar cell differentiation

[Term]
id: GO:1903681
name: regulation of epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration

[Term]
id: GO:1903682
name: negative regulation of epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "down regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration
relationship: negatively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration

[Term]
id: GO:1903683
name: positive regulation of epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "activation of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration
relationship: positively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration

[Term]
id: GO:1903684
name: regulation of border follicle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "regulation of border cell migration" BROAD [GOC:TermGenie]
is_a: GO:0010632 ! regulation of epithelial cell migration
relationship: regulates GO:0007298 ! border follicle cell migration

[Term]
id: GO:1903687
name: negative regulation of border follicle cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "inhibition of border follicle cell migration" NARROW [GOC:TermGenie]
is_a: GO:0010633 ! negative regulation of epithelial cell migration
is_a: GO:1903684 ! regulation of border follicle cell migration
relationship: negatively_regulates GO:0007298 ! border follicle cell migration

[Term]
id: GO:1903688
name: positive regulation of border follicle cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "activation of border follicle cell migration" NARROW [GOC:TermGenie]
is_a: GO:0010634 ! positive regulation of epithelial cell migration
is_a: GO:1903684 ! regulation of border follicle cell migration
relationship: positively_regulates GO:0007298 ! border follicle cell migration

[Term]
id: GO:1903689
name: regulation of wound healing, spreading of epidermal cells
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0061041 ! regulation of wound healing
relationship: regulates GO:0035313 ! wound healing, spreading of epidermal cells

[Term]
id: GO:1903690
name: negative regulation of wound healing, spreading of epidermal cells
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "down regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "down-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "downregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "inhibition of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells
relationship: negatively_regulates GO:0035313 ! wound healing, spreading of epidermal cells

[Term]
id: GO:1903691
name: positive regulation of wound healing, spreading of epidermal cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "activation of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie]
synonym: "up regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "up-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "upregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0090303 ! positive regulation of wound healing
is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells
relationship: positively_regulates GO:0035313 ! wound healing, spreading of epidermal cells

[Term]
id: GO:1903692
name: methionine import across plasma membrane
namespace: biological_process
alt_id: GO:0044690
def: "The directed movement of methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368]
synonym: "methionine import" BROAD []
synonym: "methionine import into cell" EXACT []
is_a: GO:0015821 ! methionine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1903693
name: obsolete regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656]
comment: This term was obsoleted because it does not represent a specific process.
synonym: "regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903694
name: obsolete positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656]
comment: This term was obsoleted because it does not represent a specific process.
synonym: "activation of G1 mitotic cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie]
synonym: "activation of mitotic G1 cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie]
synonym: "positive regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903695
name: obsolete MAPK cascade involved in ascospore formation
namespace: biological_process
def: "OBSOLETE. Any MAPK cascade that is involved in ascospore formation." [GO_REF:0000060, GOC:TermGenie, PMID:8443406]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "ERK/MAPK cascade involved in ascospore biosynthesis" NARROW [GOC:TermGenie]
synonym: "ERK/MAPK cascade involved in ascospore formation" NARROW [GOC:TermGenie]
synonym: "MAP kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAP kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "MAP kinase kinase kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAP kinase kinase kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "MAPK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAPK signal transduction involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAPK signal transduction involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "MAPK signaling involved in ascospore biosynthesis" RELATED [GOC:TermGenie]
synonym: "MAPK signaling involved in ascospore formation" RELATED [GOC:TermGenie]
synonym: "MAPK signalling involved in ascospore biosynthesis" RELATED [GOC:TermGenie]
synonym: "MAPK signalling involved in ascospore formation" RELATED [GOC:TermGenie]
synonym: "MAPKKK cascade during sporulation involved in ascospore biosynthesis" NARROW [GOC:TermGenie]
synonym: "MAPKKK cascade during sporulation involved in ascospore formation" NARROW [GOC:TermGenie]
synonym: "MAPKKK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAPKKK cascade involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mitogen-activated protein kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mitogen-activated protein kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903696
name: protein localization to horsetail-astral microtubule array
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a horsetail-astral microtubule array." [GO_REF:0000087, GOC:TermGenie, PMID:11907273]
synonym: "protein localisation in horsetail-astral microtubule array" EXACT [GOC:TermGenie]
synonym: "protein localisation to horsetail-astral microtubule array" EXACT [GOC:TermGenie]
synonym: "protein localization in horsetail-astral microtubule array" EXACT [GOC:TermGenie]
is_a: GO:0072699 ! protein localization to cortical microtubule cytoskeleton

[Term]
id: GO:1903697
name: negative regulation of microvillus assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0032534 ! regulation of microvillus assembly
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
relationship: negatively_regulates GO:0030033 ! microvillus assembly

[Term]
id: GO:1903698
name: positive regulation of microvillus assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0032534 ! regulation of microvillus assembly
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
relationship: positively_regulates GO:0030033 ! microvillus assembly

[Term]
id: GO:1903699
name: tarsal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tarsal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:20664693]
synonym: "gland of Meibom development" EXACT [GOC:TermGenie]
synonym: "glandula tarsales development" EXACT [GOC:TermGenie]
synonym: "Meibomian gland development" EXACT [GOC:TermGenie]
synonym: "tarsoconjunctival gland development" RELATED [GOC:TermGenie]
is_a: GO:0048733 ! sebaceous gland development

[Term]
id: GO:1903700
name: caecum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a caecum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]
synonym: "blind intestine development" RELATED [GOC:TermGenie]
synonym: "blindgut development" RELATED [GOC:TermGenie]
synonym: "caeca development" NARROW [GOC:TermGenie]
synonym: "ceca development" NARROW [GOC:TermGenie]
synonym: "cecum development" EXACT [GOC:TermGenie]
synonym: "intestinum caecum development" RELATED [GOC:TermGenie]
synonym: "intestinum crassum caecum development" EXACT [GOC:TermGenie]
synonym: "intestinum crassum cecum development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1903701
name: substantia propria of cornea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382]
synonym: "corneal stroma development" EXACT [GOC:TermGenie]
synonym: "stroma of cornea development" EXACT [GOC:TermGenie]
synonym: "substantia propria development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1903702
name: esophagus development
namespace: biological_process
def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]
synonym: "esophageal development" EXACT [MGI:csmith]
synonym: "gullet development" EXACT [GOC:TermGenie]
synonym: "oesophagus development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1903703
name: enterocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte." [GO_REF:0000086, GOC:TermGenie, PMID:16782882, Wikipedia:List_of_intestinal_epithelial_differentiation_genes]
is_a: GO:0060575 ! intestinal epithelial cell differentiation

[Term]
id: GO:1903704
name: negative regulation of siRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of siRNA processing." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182]
synonym: "down regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "downregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "inhibition of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "inhibition of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA interference, production of siRNA" NARROW [GOC:TermGenie]
synonym: "negative regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "negative regulation of production of siRNA involved in post-transcriptional gene silencing by RNA" RELATED []
synonym: "negative regulation of production of siRNA involved in PTGS" EXACT []
synonym: "negative regulation of production of siRNA involved in RNA interference" EXACT []
synonym: "negative regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "negative regulation of siRNA production" RELATED []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0070921 ! regulation of siRNA processing
relationship: negatively_regulates GO:0030422 ! siRNA processing

[Term]
id: GO:1903705
name: positive regulation of siRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of siRNA processing." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182]
synonym: "activation of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "activation of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "activation of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie]
synonym: "activation of RNA interference, production of siRNA" NARROW [GOC:TermGenie]
synonym: "positive regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "positive regulation of production of siRNA involved in post-transcriptional gene silencing by RNA" RELATED []
synonym: "positive regulation of production of siRNA involved in PTGS" EXACT []
synonym: "positive regulation of production of siRNA involved in RNA interference" EXACT []
synonym: "positive regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "positive regulation of siRNA production" RELATED []
synonym: "up regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "upregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0070921 ! regulation of siRNA processing
relationship: positively_regulates GO:0030422 ! siRNA processing

[Term]
id: GO:1903706
name: regulation of hemopoiesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0030097 ! hemopoiesis

[Term]
id: GO:1903707
name: negative regulation of hemopoiesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
relationship: negatively_regulates GO:0030097 ! hemopoiesis

[Term]
id: GO:1903708
name: positive regulation of hemopoiesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of blood cell formation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
relationship: positively_regulates GO:0030097 ! hemopoiesis

[Term]
id: GO:1903709
name: uterine gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:23619340]
synonym: "endometrial gland development" EXACT [GOC:TermGenie]
synonym: "endometrium gland development" EXACT [GOC:TermGenie]
synonym: "glandulae uterinae development" RELATED [GOC:TermGenie]
synonym: "glandular part of endometrium development" RELATED [GOC:TermGenie]
synonym: "set of uterine glands development" RELATED [GOC:TermGenie]
synonym: "uterine glands development" EXACT [GOC:TermGenie]
synonym: "uterine glands set development" EXACT [GOC:TermGenie]
is_a: GO:0048732 ! gland development

[Term]
id: GO:1903710
name: spermine transmembrane transport
namespace: biological_process
def: "The process in which spermine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075]
is_a: GO:0000296 ! spermine transport
is_a: GO:1902047 ! polyamine transmembrane transport

[Term]
id: GO:1903711
name: spermidine transmembrane transport
namespace: biological_process
def: "The process in which spermidine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075]
is_a: GO:0015848 ! spermidine transport
is_a: GO:1902047 ! polyamine transmembrane transport

[Term]
id: GO:1903712
name: cysteine transmembrane transport
namespace: biological_process
def: "The directed movement of cysteine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:17435223]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0042883 ! cysteine transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1903713
name: asparagine transmembrane transport
namespace: biological_process
def: "The directed movement of asparagine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18503766]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0042886 ! amide transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1903714
name: isoleucine transmembrane transport
namespace: biological_process
def: "The directed movement of isoleucine across a membrane by means of some agent such as a transporter or a pore." [GO_REF:0000069, GOC:TermGenie, PMID:18503766]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015818 ! isoleucine transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1903715
name: regulation of aerobic respiration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aerobic respiration." [GO_REF:0000058, GOC:TermGenie, PMID:19266076]
is_a: GO:0043457 ! regulation of cellular respiration
relationship: regulates GO:0009060 ! aerobic respiration

[Term]
id: GO:1903716
name: guanine transmembrane transport
namespace: biological_process
def: "The process in which guanine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:14998997]
is_a: GO:0015854 ! guanine transport
is_a: GO:1904823 ! purine nucleobase transmembrane transport

[Term]
id: GO:1903719
name: regulation of I-kappaB phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:23675531]
subset: gocheck_obsoletion_candidate
synonym: "regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001932 ! regulation of protein phosphorylation
relationship: regulates GO:0007252 ! I-kappaB phosphorylation

[Term]
id: GO:1903720
name: negative regulation of I-kappaB phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:23675531]
subset: gocheck_obsoletion_candidate
synonym: "inhibition of I-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of IkappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of IKB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:1903719 ! regulation of I-kappaB phosphorylation
relationship: negatively_regulates GO:0007252 ! I-kappaB phosphorylation

[Term]
id: GO:1903721
name: positive regulation of I-kappaB phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:23675531]
subset: gocheck_obsoletion_candidate
synonym: "activation of I-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of IkappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of IKB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:1903719 ! regulation of I-kappaB phosphorylation
relationship: positively_regulates GO:0007252 ! I-kappaB phosphorylation

[Term]
id: GO:1903722
name: regulation of centriole elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0061511 ! centriole elongation

[Term]
id: GO:1903723
name: negative regulation of centriole elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]
synonym: "down regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of centriole elongation" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1903722 ! regulation of centriole elongation
relationship: negatively_regulates GO:0061511 ! centriole elongation

[Term]
id: GO:1903724
name: positive regulation of centriole elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]
synonym: "activation of centriole elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of centriole elongation" EXACT [GOC:TermGenie]
is_a: GO:0046601 ! positive regulation of centriole replication
is_a: GO:1903722 ! regulation of centriole elongation
relationship: positively_regulates GO:0061511 ! centriole elongation

[Term]
id: GO:1903725
name: regulation of phospholipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]
synonym: "regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: regulates GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:1903726
name: negative regulation of phospholipid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]
synonym: "down regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipid metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipid metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: negatively_regulates GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:1903727
name: positive regulation of phospholipid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]
synonym: "activation of phospholipid metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of phospholipid metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
relationship: positively_regulates GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:1903728
name: luteal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells." [GO_REF:0000086, GOC:TermGenie, MP:0001133]
synonym: "lutein cell differentiation" EXACT [CL:0000175]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:1903729
name: regulation of plasma membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900]
synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie]
synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0007009 ! plasma membrane organization

[Term]
id: GO:1903730
name: regulation of phosphatidate phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22334681, PMID:24876385, PMID:25359770]
comment: Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity
subset: gocheck_obsoletion_candidate
synonym: "regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0010921 ! regulation of phosphatase activity
relationship: part_of GO:0010866 ! regulation of triglyceride biosynthetic process
relationship: part_of GO:0071071 ! regulation of phospholipid biosynthetic process

[Term]
id: GO:1903740
name: obsolete positive regulation of phosphatidate phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:25359770]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903741
name: obsolete negative regulation of phosphatidate phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:22334681]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903742
name: regulation of anterograde synaptic vesicle transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25329901]
subset: goslim_synapse
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1902803 ! regulation of synaptic vesicle transport
relationship: regulates GO:0048490 ! anterograde synaptic vesicle transport

[Term]
id: GO:1903743
name: negative regulation of anterograde synaptic vesicle transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25329901]
synonym: "down regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1902804 ! negative regulation of synaptic vesicle transport
is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport
relationship: negatively_regulates GO:0048490 ! anterograde synaptic vesicle transport

[Term]
id: GO:1903744
name: positive regulation of anterograde synaptic vesicle transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25329901]
synonym: "activation of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1902805 ! positive regulation of synaptic vesicle transport
is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport
relationship: positively_regulates GO:0048490 ! anterograde synaptic vesicle transport

[Term]
id: GO:1903745
name: negative regulation of nematode pharyngeal pumping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nematode pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25329901]
synonym: "down regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "down regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "down-regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "down-regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "downregulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "downregulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "inhibition of pharyngeal pumping" NARROW [GOC:TermGenie]
synonym: "inhibition of pumping behavior" RELATED [GOC:TermGenie]
synonym: "negative regulation of pumping behavior" RELATED [GOC:TermGenie]
is_a: GO:0043051 ! regulation of nematode pharyngeal pumping
is_a: GO:1903999 ! negative regulation of eating behavior
relationship: negatively_regulates GO:0043050 ! nematode pharyngeal pumping

[Term]
id: GO:1903746
name: positive regulation of nematode pharyngeal pumping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nematode pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25329901]
synonym: "activation of pharyngeal pumping" NARROW [GOC:TermGenie]
synonym: "activation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "positive regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "up regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "up regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "up-regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "up-regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "upregulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "upregulation of pumping behavior" RELATED [GOC:TermGenie]
is_a: GO:0043051 ! regulation of nematode pharyngeal pumping
is_a: GO:1904000 ! positive regulation of eating behavior
relationship: positively_regulates GO:0043050 ! nematode pharyngeal pumping

[Term]
id: GO:1903747
name: regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
relationship: regulates GO:0072655 ! establishment of protein localization to mitochondrion

[Term]
id: GO:1903748
name: negative regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "down regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
is_a: GO:1904950 ! negative regulation of establishment of protein localization
relationship: negatively_regulates GO:0072655 ! establishment of protein localization to mitochondrion

[Term]
id: GO:1903749
name: positive regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "activation of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
is_a: GO:1904951 ! positive regulation of establishment of protein localization
relationship: positively_regulates GO:0072655 ! establishment of protein localization to mitochondrion

[Term]
id: GO:1903750
name: regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
relationship: regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide

[Term]
id: GO:1903751
name: negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "down regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "inhibition of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "negative regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
is_a: GO:1901299 ! negative regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: negatively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide

[Term]
id: GO:1903752
name: positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "activation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "positive regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "up-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "upregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
is_a: GO:1901300 ! positive regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: positively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide

[Term]
id: GO:1903753
name: negative regulation of p38MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "down regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "inhibition of p38 cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of p38 MAPK cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of p38MAPK cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of osmosensory signaling MAPK cascade" NARROW []
synonym: "negative regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:1900744 ! regulation of p38MAPK cascade
relationship: negatively_regulates GO:0038066 ! p38MAPK cascade

[Term]
id: GO:1903754
name: cortical microtubule plus-end
namespace: cellular_component
def: "The plus-end of a cortical microtubule." [GO_REF:0000064, GOC:TermGenie, GOC:vw]
synonym: "cortical microtubule plus end" EXACT []
is_a: GO:1904511 ! cytoplasmic microtubule plus-end
relationship: part_of GO:0055028 ! cortical microtubule

[Term]
id: GO:1903755
name: positive regulation of SUMO transferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of SUMO transferase activity." [GO_REF:0000059, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:19955185]
subset: gocheck_obsoletion_candidate
synonym: "activation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "activation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "activation of SUMO transferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of SUMO transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of SUMO transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "upregulation of SUMO transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1903182 ! regulation of SUMO transferase activity

[Term]
id: GO:1903759
name: obsolete signal transduction involved in regulation of aerobic respiration
namespace: biological_process
def: "OBSOLETE. Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076]
comment: The reason for obsoletion is that this represents a GO-CAM model.
synonym: "signaling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903760
name: regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]
subset: gocheck_obsoletion_candidate
synonym: "regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1903761
name: obsolete negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "down regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "downregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903762
name: positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]
subset: gocheck_obsoletion_candidate
synonym: "activation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "upregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1903760 ! regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity
is_a: GO:1905026 ! positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential

[Term]
id: GO:1903763
name: gap junction channel activity involved in cell communication by electrical coupling
namespace: molecular_function
def: "Any gap junction channel activity that is involved in cell communication by electrical coupling." [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307]
synonym: "connexin involved in cell communication by electrical coupling" RELATED [GOC:TermGenie]
synonym: "innexin channel activity involved in cell communication by electrical coupling" EXACT [GOC:TermGenie]
synonym: "innexin involved in cell communication by electrical coupling" NARROW [GOC:TermGenie]
is_a: GO:0005243 ! gap junction channel activity

[Term]
id: GO:1903764
name: regulation of potassium ion export across plasma membrane
namespace: biological_process
alt_id: GO:1902302
def: "Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]
synonym: "regulation of potassium export" BROAD [GOC:TermGenie]
synonym: "regulation of potassium export across plasma membrane" BROAD [GOC:TermGenie]
synonym: "regulation of potassium ion export" BROAD []
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
relationship: regulates GO:0097623 ! potassium ion export across plasma membrane

[Term]
id: GO:1903765
name: negative regulation of potassium ion export across plasma membrane
namespace: biological_process
alt_id: GO:1902303
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]
synonym: "down regulation of potassium export" BROAD [GOC:TermGenie]
synonym: "down regulation of potassium ion export" BROAD [GOC:TermGenie]
synonym: "down regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium export" BROAD [GOC:TermGenie]
synonym: "down-regulation of potassium ion export" BROAD [GOC:TermGenie]
synonym: "down-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium export" BROAD [GOC:TermGenie]
synonym: "downregulation of potassium ion export" BROAD [GOC:TermGenie]
synonym: "downregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium export" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium ion export" RELATED [GOC:TermGenie]
synonym: "inhibition of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of potassium export" BROAD [GOC:TermGenie]
synonym: "negative regulation of potassium ion export" BROAD []
is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport
is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane
relationship: negatively_regulates GO:0097623 ! potassium ion export across plasma membrane

[Term]
id: GO:1903766
name: positive regulation of potassium ion export across plasma membrane
namespace: biological_process
alt_id: GO:1902304
def: "Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]
synonym: "activation of potassium export" RELATED [GOC:TermGenie]
synonym: "activation of potassium ion export" RELATED [GOC:TermGenie]
synonym: "activation of potassium ion export across plasma membrane" RELATED [GOC:TermGenie]
synonym: "positive regulation of potassium export" BROAD [GOC:TermGenie]
synonym: "positive regulation of potassium ion export" BROAD []
synonym: "up regulation of potassium export" BROAD [GOC:TermGenie]
synonym: "up regulation of potassium ion export" BROAD [GOC:TermGenie]
synonym: "up regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium export" BROAD [GOC:TermGenie]
synonym: "up-regulation of potassium ion export" BROAD [GOC:TermGenie]
synonym: "up-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium export" BROAD [GOC:TermGenie]
synonym: "upregulation of potassium ion export" BROAD [GOC:TermGenie]
synonym: "upregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport
is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane
relationship: positively_regulates GO:0097623 ! potassium ion export across plasma membrane

[Term]
id: GO:1903767
name: sweet taste receptor complex
namespace: cellular_component
def: "A protein complex which is capable of sweet taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]
is_a: GO:1903768 ! taste receptor complex

[Term]
id: GO:1903768
name: taste receptor complex
namespace: cellular_component
def: "A protein complex which is capable of taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:1903769
name: negative regulation of cell proliferation in bone marrow
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in bone marrow." [GO_REF:0000058, GOC:TermGenie, PMID:9241534]
synonym: "down regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie]
synonym: "downregulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie]
synonym: "inhibition of bone marrow cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation in bone marrow" NARROW [GOC:TermGenie]
synonym: "negative regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0071863 ! regulation of cell proliferation in bone marrow
relationship: negatively_regulates GO:0071838 ! cell proliferation in bone marrow

[Term]
id: GO:1903770
name: negative regulation of beta-galactosidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "down regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "down regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "down regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "down regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "down regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "down regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "down regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "down-regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "down-regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "down-regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "down-regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "down-regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "down-regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "down-regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "downregulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "downregulation of lactozym" RELATED [GOC:TermGenie]
synonym: "downregulation of maxilact" RELATED [GOC:TermGenie]
synonym: "downregulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "downregulation of S 2107" RELATED [GOC:TermGenie]
synonym: "downregulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "downregulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-D-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-galactosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrolact" RELATED [GOC:TermGenie]
synonym: "inhibition of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "inhibition of lactozym" RELATED [GOC:TermGenie]
synonym: "inhibition of maxilact" RELATED [GOC:TermGenie]
synonym: "inhibition of oryzatym" RELATED [GOC:TermGenie]
synonym: "inhibition of S 2107" RELATED [GOC:TermGenie]
synonym: "inhibition of sumiklat" RELATED [GOC:TermGenie]
synonym: "inhibition of trilactase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "negative regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "negative regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "negative regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "negative regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "negative regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "negative regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "negative regulation of trilactase activity" EXACT [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:1903771
name: positive regulation of beta-galactosidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518]
subset: gocheck_obsoletion_candidate
synonym: "activation of beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-D-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-galactosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrolact" RELATED [GOC:TermGenie]
synonym: "activation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "activation of lactozym" RELATED [GOC:TermGenie]
synonym: "activation of maxilact" RELATED [GOC:TermGenie]
synonym: "activation of oryzatym" RELATED [GOC:TermGenie]
synonym: "activation of S 2107" RELATED [GOC:TermGenie]
synonym: "activation of sumiklat" RELATED [GOC:TermGenie]
synonym: "activation of trilactase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "positive regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "positive regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "positive regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "positive regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "positive regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "positive regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "positive regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "up regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "up regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "up regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "up regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "up regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "up regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "up regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "up-regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "up-regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "up-regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "up-regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "up-regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "up-regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "up-regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "upregulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "upregulation of lactozym" RELATED [GOC:TermGenie]
synonym: "upregulation of maxilact" RELATED [GOC:TermGenie]
synonym: "upregulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "upregulation of S 2107" RELATED [GOC:TermGenie]
synonym: "upregulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "upregulation of trilactase activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:1903772
name: regulation of viral budding via host ESCRT complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]
synonym: "regulation of host-assisted viral budding" BROAD [GOC:TermGenie]
synonym: "regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
is_a: GO:0050792 ! regulation of viral process
relationship: regulates GO:0039702 ! viral budding via host ESCRT complex

[Term]
id: GO:1903773
name: negative regulation of viral budding via host ESCRT complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]
synonym: "down regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "down regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "downregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "downregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "inhibition of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "inhibition of viral budding via host ESCRT complex" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex
is_a: GO:1903901 ! negative regulation of viral life cycle
relationship: negatively_regulates GO:0039702 ! viral budding via host ESCRT complex

[Term]
id: GO:1903774
name: positive regulation of viral budding via host ESCRT complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]
synonym: "activation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "activation of viral budding via host ESCRT complex" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "up regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "up regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "upregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "upregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex
is_a: GO:1903902 ! positive regulation of viral life cycle
relationship: positively_regulates GO:0039702 ! viral budding via host ESCRT complex

[Term]
id: GO:1903775
name: regulation of DNA double-strand break processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA double-strand break processing." [GO_REF:0000058, GOC:TermGenie, PMID:25203555]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0000729 ! DNA double-strand break processing

[Term]
id: GO:1903776
name: regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair via single-strand annealing, removal of nonhomologous ends." [GO_REF:0000058, GOC:TermGenie, PMID:25203555]
is_a: GO:2000779 ! regulation of double-strand break repair
relationship: regulates GO:0000736 ! double-strand break repair via single-strand annealing, removal of nonhomologous ends

[Term]
id: GO:1903777
name: melibiose binding
namespace: molecular_function
def: "Binding to melibiose." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:11471732]
is_a: GO:0048030 ! disaccharide binding

[Term]
id: GO:1903778
name: protein localization to vacuolar membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562]
synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0072665 ! protein localization to vacuole

[Term]
id: GO:1903779
name: regulation of cardiac conduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
is_a: GO:0008016 ! regulation of heart contraction
relationship: regulates GO:0061337 ! cardiac conduction

[Term]
id: GO:1903780
name: negative regulation of cardiac conduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1903779 ! regulation of cardiac conduction
relationship: negatively_regulates GO:0061337 ! cardiac conduction

[Term]
id: GO:1903781
name: positive regulation of cardiac conduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1903779 ! regulation of cardiac conduction
relationship: positively_regulates GO:0061337 ! cardiac conduction

[Term]
id: GO:1903782
name: regulation of sodium ion import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
relationship: regulates GO:0098719 ! sodium ion import across plasma membrane

[Term]
id: GO:1903783
name: negative regulation of sodium ion import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]
synonym: "down regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium ion import across plasma membrane" NARROW [GOC:TermGenie]
is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport
is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane
relationship: negatively_regulates GO:0098719 ! sodium ion import across plasma membrane

[Term]
id: GO:1903784
name: positive regulation of sodium ion import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]
synonym: "activation of sodium ion import across plasma membrane" NARROW [GOC:TermGenie]
synonym: "up regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport
is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane
relationship: positively_regulates GO:0098719 ! sodium ion import across plasma membrane

[Term]
id: GO:1903785
name: L-valine transmembrane transport
namespace: biological_process
def: "The directed movement of L-valine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20944394]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015829 ! valine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903786
name: regulation of glutathione biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "regulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0006750 ! glutathione biosynthetic process

[Term]
id: GO:1903787
name: negative regulation of glutathione biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of glutathione anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione formation" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1903786 ! regulation of glutathione biosynthetic process
relationship: negatively_regulates GO:0006750 ! glutathione biosynthetic process

[Term]
id: GO:1903788
name: positive regulation of glutathione biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of glutathione anabolism" NARROW [GOC:TermGenie]
synonym: "activation of glutathione biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of glutathione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of glutathione formation" NARROW [GOC:TermGenie]
synonym: "activation of glutathione synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1903786 ! regulation of glutathione biosynthetic process
relationship: positively_regulates GO:0006750 ! glutathione biosynthetic process

[Term]
id: GO:1903789
name: regulation of amino acid transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814]
synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0003333 ! amino acid transmembrane transport

[Term]
id: GO:1903790
name: guanine nucleotide transmembrane transport
namespace: biological_process
def: "The process in which a guanyl nucleotide is transported across a membrane." [GO_REF:0000069, GOC:dph, GOC:TermGenie, GOC:vw, PMID:25320081]
synonym: "guanyl nucleotide transmembrane transport" EXACT []
is_a: GO:0001408 ! guanine nucleotide transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:1903791
name: uracil transmembrane transport
namespace: biological_process
def: "The process in which uracil is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:8948441]
is_a: GO:0015857 ! uracil transport
is_a: GO:1904082 ! pyrimidine nucleobase transmembrane transport

[Term]
id: GO:1903792
name: negative regulation of monoatomic anion transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "down regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anion transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anion transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of anion transport" BROAD []
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
is_a: GO:0044070 ! regulation of monoatomic anion transport
relationship: negatively_regulates GO:0006820 ! monoatomic anion transport

[Term]
id: GO:1903793
name: positive regulation of monoatomic anion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "activation of anion transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of anion transport" BROAD []
synonym: "up regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anion transport" EXACT [GOC:TermGenie]
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
is_a: GO:0044070 ! regulation of monoatomic anion transport
relationship: positively_regulates GO:0006820 ! monoatomic anion transport

[Term]
id: GO:1903794
name: cortisol binding
namespace: molecular_function
def: "Binding to cortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:18483153]
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding

[Term]
id: GO:1903795
name: regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:1903796
name: negative regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "down regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "downregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "inhibition of inorganic anion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of inorganic anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of transmembrane inorganic anion transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "negative regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
relationship: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:1903797
name: positive regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "activation of inorganic anion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of inorganic anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "activation of transmembrane inorganic anion transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "up regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "upregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
relationship: positively_regulates GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:1903798
name: regulation of miRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microRNA processing." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA processing" BROAD [GOC:TermGenie]
synonym: "regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of miRNA maturation" NARROW []
is_a: GO:0070920 ! regulation of regulatory ncRNA processing
relationship: regulates GO:0035196 ! miRNA processing

[Term]
id: GO:1903799
name: negative regulation of miRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microRNA processing." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "down regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "down regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "down-regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "downregulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "inhibition of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of miRNA processing" NARROW [GOC:TermGenie]
synonym: "inhibition of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie]
synonym: "inhibition of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "negative regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of miRNA maturation" NARROW []
synonym: "negative regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "negative regulation of production of miRNAs involved in gene silencing by miRNA" RELATED []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0060965 ! negative regulation of miRNA-mediated gene silencing
is_a: GO:1903798 ! regulation of miRNA processing
relationship: negatively_regulates GO:0035196 ! miRNA processing

[Term]
id: GO:1903800
name: positive regulation of miRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microRNA processing." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "activation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "activation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "activation of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie]
synonym: "activation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of miRNA processing" NARROW [GOC:TermGenie]
synonym: "activation of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "activation of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie]
synonym: "activation of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of miRNA maturation" NARROW []
synonym: "positive regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "positive regulation of production of miRNAs involved in gene silencing by miRNA" RELATED []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:1903798 ! regulation of miRNA processing
is_a: GO:2000637 ! positive regulation of miRNA-mediated gene silencing
relationship: positively_regulates GO:0035196 ! miRNA processing

[Term]
id: GO:1903801
name: L-leucine import across plasma membrane
namespace: biological_process
alt_id: GO:0060356
def: "The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "L-leucine import" BROAD []
synonym: "L-leucine import into cell" EXACT []
synonym: "L-leucine uptake" NARROW []
synonym: "leucine import" BROAD []
synonym: "leucine uptake" EXACT []
is_a: GO:0015820 ! L-leucine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903803
name: L-glutamine import across plasma membrane
namespace: biological_process
alt_id: GO:0036229
def: "The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "L-glutamine import" BROAD []
synonym: "L-glutamine import into cell" EXACT []
synonym: "L-glutamine uptake" EXACT [GOC:bf]
is_a: GO:0006868 ! glutamine transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903804
name: glycine import across plasma membrane
namespace: biological_process
alt_id: GO:0036233
def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "glycine import" BROAD []
synonym: "glycine import into cell" EXACT []
is_a: GO:0015816 ! glycine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903805
name: L-valine import across plasma membrane
namespace: biological_process
alt_id: GO:0090468
def: "The directed movement of L-valine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "L-valine import into cell" EXACT []
synonym: "valine import" NARROW []
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1903785 ! L-valine transmembrane transport

[Term]
id: GO:1903806
name: L-isoleucine import across plasma membrane
namespace: biological_process
alt_id: GO:0090476
alt_id: GO:0090477
def: "The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "isoleucine import" BROAD []
synonym: "L-isoleucine import" BROAD []
synonym: "L-isoleucine import into cell" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903714 ! isoleucine transmembrane transport

[Term]
id: GO:1903807
name: L-threonine import across plasma membrane
namespace: biological_process
alt_id: GO:0036231
def: "The directed movement of L-threonine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "L-threonine import" BROAD []
synonym: "L-threonine import into cell" EXACT []
synonym: "L-threonine uptake" EXACT [GOC:bf]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015826 ! threonine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903808
name: L-tyrosine import across plasma membrane
namespace: biological_process
alt_id: GO:0036232
def: "The directed movement of L-tyrosine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "L-tyrosine import" BROAD []
synonym: "L-tyrosine import into cell" EXACT []
synonym: "L-tyrosine uptake" EXACT [GOC:bf]
is_a: GO:0015828 ! tyrosine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903810
name: L-histidine import across plasma membrane
namespace: biological_process
alt_id: GO:0061460
alt_id: GO:0090466
def: "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "histidine import" BROAD []
synonym: "L-histidine import" BROAD []
synonym: "L-histidine import into cell" EXACT []
is_a: GO:0089709 ! L-histidine transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane

[Term]
id: GO:1903811
name: L-asparagine import across plasma membrane
namespace: biological_process
alt_id: GO:0090469
def: "The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "asparagine import" BROAD []
synonym: "L-asparagine import into cell" EXACT []
is_a: GO:0006867 ! asparagine transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903713 ! asparagine transmembrane transport

[Term]
id: GO:1903812
name: L-serine import across plasma membrane
namespace: biological_process
def: "The directed movement of L-serine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "L-serine import into cell" EXACT []
is_a: GO:0015825 ! L-serine transport
is_a: GO:0098718 ! serine import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1903814
name: regulation of collecting lymphatic vessel constriction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233]
synonym: "regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0090066 ! regulation of anatomical structure size
relationship: regulates GO:1990192 ! collecting lymphatic vessel constriction

[Term]
id: GO:1903815
name: negative regulation of collecting lymphatic vessel constriction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233]
synonym: "down regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "down regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "down-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "downregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "inhibition of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie]
synonym: "inhibition of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie]
synonym: "negative regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction
relationship: negatively_regulates GO:1990192 ! collecting lymphatic vessel constriction

[Term]
id: GO:1903816
name: positive regulation of collecting lymphatic vessel constriction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233]
synonym: "activation of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie]
synonym: "activation of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie]
synonym: "positive regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "up regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "up regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "up-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "upregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "upregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction
relationship: positively_regulates GO:1990192 ! collecting lymphatic vessel constriction

[Term]
id: GO:1903817
name: negative regulation of voltage-gated potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive potassium channel" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity
is_a: GO:2001258 ! negative regulation of cation channel activity

[Term]
id: GO:1903818
name: positive regulation of voltage-gated potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384]
subset: gocheck_obsoletion_candidate
synonym: "activation of voltage gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-sensitive potassium channel" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:1903819
name: obsolete detection of stimulus involved in mitotic cytokinesis checkpoint
namespace: biological_process
def: "OBSOLETE. Any detection of stimulus that is involved in a mitotic cytokinesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "perception of stimulus involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903821
name: obsolete detection of stimulus involved in morphogenesis checkpoint
namespace: biological_process
def: "OBSOLETE. Any detection of stimulus that is involved in morphogenesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
comment: This term was obsoleted because it corresponds to a molecular function.
synonym: "detection of stimulus involved in septin checkpoint" RELATED [GOC:TermGenie]
synonym: "perception of stimulus involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "perception of stimulus involved in septin checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus detection involved in septin checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus sensing involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in septin checkpoint" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903823
name: telomere single strand break repair
namespace: biological_process
def: "Single strand break repair that takes place in a telomere." [GO_REF:0000062, GOC:TermGenie, PMID:24374808]
synonym: "single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "telomere single-strand break repair" EXACT []
synonym: "telomere SSBR" RELATED []
synonym: "telomeric single strand break repair" EXACT []
is_a: GO:0000012 ! single strand break repair

[Term]
id: GO:1903824
name: negative regulation of telomere single strand break repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair." [GO_REF:0000058, GOC:TermGenie, PMID:24374808]
synonym: "down regulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere single strand break repair" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "down regulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere single strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "down-regulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere single strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "downregulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
synonym: "inhibition of single strand break repair in telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere single strand break repair" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere single-strand break repair" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "inhibition of telomeric single strand break repair" NARROW [GOC:TermGenie]
synonym: "negative regulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "negative regulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "negative regulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "negative regulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
is_a: GO:1903517 ! negative regulation of single strand break repair
relationship: negatively_regulates GO:1903823 ! telomere single strand break repair

[Term]
id: GO:1903825
name: organic acid transmembrane transport
namespace: biological_process
def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie]
is_a: GO:0015849 ! organic acid transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1903826
name: L-arginine transmembrane transport
namespace: biological_process
alt_id: GO:0015809
alt_id: GO:0043091
alt_id: GO:1902023
alt_id: GO:1903400
def: "The directed movement of L-arginine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18357653, PMID:22822152, PMID:8195186]
synonym: "arginine transmembrane transport" RELATED []
synonym: "arginine transport" BROAD []
synonym: "L-arginine import" NARROW []
synonym: "L-arginine transport" BROAD []
synonym: "L-arginine uptake" NARROW []
is_a: GO:0015695 ! organic cation transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1990822 ! basic amino acid transmembrane transport

[Term]
id: GO:1903828
name: negative regulation of protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein localization" EXACT []
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0008104 ! protein localization

[Term]
id: GO:1903829
name: positive regulation of protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein localization" EXACT []
synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0008104 ! protein localization

[Term]
id: GO:1903830
name: magnesium ion transmembrane transport
namespace: biological_process
def: "The directed movement of magnesium ion across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11254124]
is_a: GO:0015693 ! magnesium ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:1903831
name: signal transduction involved in cellular response to ammonium ion
namespace: biological_process
def: "Any signal transduction that is involved in cellular response to ammonium ion." [GO_REF:0000060, GOC:TermGenie, PMID:16297994]
synonym: "signaling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie]
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071242 ! cellular response to ammonium ion

[Term]
id: GO:1903832
name: regulation of cellular response to amino acid starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0034198 ! cellular response to amino acid starvation

[Term]
id: GO:1903833
name: positive regulation of cellular response to amino acid starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840]
synonym: "activation of cellular response to amino acid starvation" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903832 ! regulation of cellular response to amino acid starvation
relationship: positively_regulates GO:0034198 ! cellular response to amino acid starvation

[Term]
id: GO:1903837
name: regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
subset: gocheck_do_not_annotate
synonym: "regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding

[Term]
id: GO:1903838
name: negative regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
subset: gocheck_do_not_annotate
synonym: "down regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA 3' UTR binding" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA 3'-UTR binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding
is_a: GO:1904572 ! negative regulation of mRNA binding

[Term]
id: GO:1903839
name: positive regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
subset: gocheck_do_not_annotate
synonym: "activation of mRNA 3' UTR binding" NARROW [GOC:TermGenie]
synonym: "activation of mRNA 3'-UTR binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding

[Term]
id: GO:1903840
name: response to arsenite(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0046685 ! response to arsenic-containing substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903841
name: cellular response to arsenite(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0071243 ! cellular response to arsenic-containing substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903840 ! response to arsenite(3-)

[Term]
id: GO:1903842
name: response to arsenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0046685 ! response to arsenic-containing substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903843
name: cellular response to arsenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0071243 ! cellular response to arsenic-containing substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903842 ! response to arsenite ion

[Term]
id: GO:1903844
name: regulation of cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus

[Term]
id: GO:1903845
name: negative regulation of cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus
relationship: negatively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus

[Term]
id: GO:1903846
name: positive regulation of cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus
relationship: positively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus

[Term]
id: GO:1903847
name: regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
is_a: GO:1905651 ! regulation of artery morphogenesis
relationship: regulates GO:0035909 ! aorta morphogenesis

[Term]
id: GO:1903848
name: negative regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:1905652 ! negative regulation of artery morphogenesis
relationship: negatively_regulates GO:0035909 ! aorta morphogenesis

[Term]
id: GO:1903849
name: positive regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:1905653 ! positive regulation of artery morphogenesis
relationship: positively_regulates GO:0035909 ! aorta morphogenesis

[Term]
id: GO:1903850
name: regulation of cristae formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]
comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype
is_a: GO:0010821 ! regulation of mitochondrion organization
relationship: regulates GO:0042407 ! cristae formation

[Term]
id: GO:1903851
name: negative regulation of cristae formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]
comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype
synonym: "down regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cristae formation" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1903850 ! regulation of cristae formation
relationship: negatively_regulates GO:0042407 ! cristae formation

[Term]
id: GO:1903852
name: positive regulation of cristae formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]
comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype
synonym: "activation of cristae formation" NARROW [GOC:TermGenie]
synonym: "up regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cristae formation" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1903850 ! regulation of cristae formation
relationship: positively_regulates GO:0042407 ! cristae formation

[Term]
id: GO:1903853
name: regulation of stress response to copper ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]
synonym: "regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "regulation of stress response to copper" BROAD [GOC:TermGenie]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:1990169 ! stress response to copper ion

[Term]
id: GO:1903854
name: negative regulation of stress response to copper ion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]
synonym: "down regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "down regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "down regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "down-regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "downregulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "downregulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "inhibition of response to copper ion stress" NARROW [GOC:TermGenie]
synonym: "inhibition of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "inhibition of stress response to copper ion" NARROW [GOC:TermGenie]
synonym: "negative regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to copper toxicity" RELATED [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1903853 ! regulation of stress response to copper ion
relationship: negatively_regulates GO:1990169 ! stress response to copper ion

[Term]
id: GO:1903855
name: positive regulation of stress response to copper ion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]
synonym: "activation of response to copper ion stress" NARROW [GOC:TermGenie]
synonym: "activation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "activation of stress response to copper ion" NARROW [GOC:TermGenie]
synonym: "positive regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "up regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "up-regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "upregulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "upregulation of stress response to copper ion" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903853 ! regulation of stress response to copper ion
relationship: positively_regulates GO:1990169 ! stress response to copper ion

[Term]
id: GO:1903856
name: regulation of cytokinin dehydrogenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1903857
name: obsolete negative regulation of cytokinin dehydrogenase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinin dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N6-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903858
name: protein localization to old growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an old growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:17895368]
synonym: "protein localisation in old growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to old growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in old growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:1902486 ! protein localization to growing cell tip

[Term]
id: GO:1903859
name: regulation of dendrite extension
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]
comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype.
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0097484 ! dendrite extension

[Term]
id: GO:1903860
name: negative regulation of dendrite extension
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]
comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype.
synonym: "down regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "down-regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "downregulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "inhibition of dendrite extension" NARROW [GOC:TermGenie]
synonym: "up regulation of dendrite retraction" EXACT [GOC:pad]
synonym: "up-regulation of dendrite retraction" EXACT [GOC:pad]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1903859 ! regulation of dendrite extension
relationship: negatively_regulates GO:0097484 ! dendrite extension

[Term]
id: GO:1903861
name: positive regulation of dendrite extension
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]
comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype.
synonym: "activation of dendrite extension" NARROW [GOC:TermGenie]
synonym: "up regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "up-regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "upregulation of dendrite extension" EXACT [GOC:TermGenie]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1903859 ! regulation of dendrite extension
relationship: positively_regulates GO:0097484 ! dendrite extension

[Term]
id: GO:1903862
name: positive regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:10225962]
synonym: "activation of oxidative phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of respiratory-chain phosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0002082 ! regulation of oxidative phosphorylation
is_a: GO:1901857 ! positive regulation of cellular respiration
relationship: positively_regulates GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:1903863
name: P granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a P granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836]
synonym: "germline granule assembly" EXACT [GOC:TermGenie]
synonym: "germline granule formation" EXACT [GOC:TermGenie]
synonym: "P granule formation" EXACT [GOC:TermGenie]
synonym: "polar granule assembly" EXACT [GOC:TermGenie]
synonym: "polar granule formation" EXACT [GOC:TermGenie]
is_a: GO:0030719 ! P granule organization
is_a: GO:0140694 ! membraneless organelle assembly

[Term]
id: GO:1903864
name: P granule disassembly
namespace: biological_process
def: "The disaggregation of a P granule into its constituent components." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836]
synonym: "germline granule disassembly" EXACT [GOC:TermGenie]
synonym: "polar granule disassembly" EXACT [GOC:TermGenie]
is_a: GO:0030719 ! P granule organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:1903865
name: sigma factor antagonist complex
namespace: cellular_component
def: "A protein complex which is capable of sigma factor antagonist activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23687042]
is_a: GO:0005667 ! transcription regulator complex

[Term]
id: GO:1903866
name: palisade mesophyll development
namespace: biological_process
def: "The process whose specific outcome is the progression of a palisade mesophyll over time, from its formation to the mature structure." [GO_REF:0000080, GOC:TermGenie, PMID:24663344]
synonym: "palisade parenchyma development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1903867
name: extraembryonic membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1903868
name: regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of MetF" RELATED [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of MTHFR activity" BROAD [GOC:TermGenie]
synonym: "regulation of N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1903869
name: obsolete negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of MetF" RELATED [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "down regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of MetF" RELATED [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "down-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of MetF" RELATED [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "downregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of MetF" RELATED [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "inhibition of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of MetF" RELATED [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "negative regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903870
name: obsolete positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of MetF" RELATED [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "activation of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of MetF" RELATED [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "positive regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of MetF" RELATED [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "up regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of MetF" RELATED [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "up-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of MetF" RELATED [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "upregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903871
name: DNA recombinase mediator complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a DNA recombinase mediator complex." [GO_REF:0000079, GOC:rb, GOC:TermGenie, PMID:18347097]
synonym: "DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
is_a: GO:0090735 ! DNA repair complex assembly

[Term]
id: GO:1903872
name: regulation of DNA recombinase mediator complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097]
synonym: "regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1903871 ! DNA recombinase mediator complex assembly

[Term]
id: GO:1903873
name: negative regulation of DNA recombinase mediator complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097]
synonym: "down regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA recombinase mediator complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA recombinase mediator complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1903872 ! regulation of DNA recombinase mediator complex assembly
relationship: negatively_regulates GO:1903871 ! DNA recombinase mediator complex assembly

[Term]
id: GO:1903875
name: corticosterone binding
namespace: molecular_function
def: "Binding to corticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding

[Term]
id: GO:1903876
name: 11-deoxycortisol binding
namespace: molecular_function
def: "Binding to 11-deoxycortisol." [GO_REF:0000067, GOC:TermGenie, PMID:10802282]
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding

[Term]
id: GO:1903877
name: 21-deoxycortisol binding
namespace: molecular_function
def: "Binding to 21-deoxycortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:1903878
name: 11-deoxycorticosterone binding
namespace: molecular_function
def: "Binding to 11-deoxycorticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding

[Term]
id: GO:1903879
name: 11beta-hydroxyprogesterone binding
namespace: molecular_function
def: "Binding to 11beta-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding

[Term]
id: GO:1903880
name: 17alpha-hydroxyprogesterone binding
namespace: molecular_function
def: "Binding to 17alpha-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:1903881
name: regulation of interleukin-17-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0097400 ! interleukin-17-mediated signaling pathway

[Term]
id: GO:1903882
name: negative regulation of interleukin-17-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "down regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway
relationship: negatively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway

[Term]
id: GO:1903883
name: positive regulation of interleukin-17-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "activation of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway
relationship: positively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway

[Term]
id: GO:1903884
name: regulation of chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "regulation of CCL20 production" EXACT [GOC:TermGenie]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production

[Term]
id: GO:1903885
name: negative regulation of chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "down regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "down regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "down regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "down regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "inhibition of C-C motif chemokine 20 production" NARROW [GOC:TermGenie]
synonym: "inhibition of CCL-20 production" NARROW [GOC:TermGenie]
synonym: "inhibition of CCL20 production" NARROW [GOC:TermGenie]
synonym: "inhibition of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie]
synonym: "negative regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "negative regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "negative regulation of CCL20 production" EXACT [GOC:TermGenie]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production
relationship: negatively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production

[Term]
id: GO:1903886
name: positive regulation of chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "activation of C-C motif chemokine 20 production" NARROW [GOC:TermGenie]
synonym: "activation of CCL-20 production" NARROW [GOC:TermGenie]
synonym: "activation of CCL20 production" NARROW [GOC:TermGenie]
synonym: "activation of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie]
synonym: "positive regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "positive regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "positive regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production
relationship: positively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production

[Term]
id: GO:1903888
name: regulation of plant epidermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0090627 ! plant epidermal cell differentiation

[Term]
id: GO:1903889
name: negative regulation of plant epidermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345]
synonym: "down regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of plant epidermal cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
relationship: negatively_regulates GO:0090627 ! plant epidermal cell differentiation

[Term]
id: GO:1903890
name: positive regulation of plant epidermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345]
synonym: "activation of plant epidermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
relationship: positively_regulates GO:0090627 ! plant epidermal cell differentiation

[Term]
id: GO:1903891
name: regulation of ATF6-mediated unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "regulation of ATF6 signal transduction pathway" BROAD [GOC:TermGenie]
synonym: "regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
relationship: regulates GO:0036500 ! ATF6-mediated unfolded protein response

[Term]
id: GO:1903892
name: negative regulation of ATF6-mediated unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "down regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "down regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "down regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "down-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "downregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "downregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "downregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "downregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "downregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "inhibition of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6 branch of UPR" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "inhibition of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie]
synonym: "negative regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response
relationship: negatively_regulates GO:0036500 ! ATF6-mediated unfolded protein response

[Term]
id: GO:1903893
name: positive regulation of ATF6-mediated unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "activation of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of ATF6 branch of UPR" NARROW [GOC:TermGenie]
synonym: "activation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "activation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "activation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "activation of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie]
synonym: "activation of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie]
synonym: "positive regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "up regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "up regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "up regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "up-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "upregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "upregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "upregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "upregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "upregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response
relationship: positively_regulates GO:0036500 ! ATF6-mediated unfolded protein response

[Term]
id: GO:1903894
name: regulation of IRE1-mediated unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "regulation of IRE1 signal transduction pathway" BROAD [GOC:TermGenie]
synonym: "regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
relationship: regulates GO:0036498 ! IRE1-mediated unfolded protein response

[Term]
id: GO:1903895
name: negative regulation of IRE1-mediated unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "down regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "down regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "down-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "downregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "downregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "downregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "downregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "downregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "inhibition of IRE1 branch of UPR" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "inhibition of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "negative regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "negative regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "negative regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "negative regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response
relationship: negatively_regulates GO:0036498 ! IRE1-mediated unfolded protein response

[Term]
id: GO:1903896
name: positive regulation of IRE1-mediated unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "activation of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie]
synonym: "activation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "activation of IRE1 branch of UPR" NARROW [GOC:TermGenie]
synonym: "activation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "activation of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "positive regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "positive regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "positive regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "positive regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "up regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "up-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "upregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "upregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "upregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "upregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "upregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response
relationship: positively_regulates GO:0036498 ! IRE1-mediated unfolded protein response

[Term]
id: GO:1903897
name: regulation of PERK-mediated unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "regulation of PERK signal transduction pathway" BROAD [GOC:TermGenie]
synonym: "regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
relationship: regulates GO:0036499 ! PERK-mediated unfolded protein response

[Term]
id: GO:1903898
name: negative regulation of PERK-mediated unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "down regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "down regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "downregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "downregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of PERK branch of UPR" NARROW [GOC:TermGenie]
synonym: "inhibition of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "inhibition of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie]
synonym: "negative regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response
relationship: negatively_regulates GO:0036499 ! PERK-mediated unfolded protein response

[Term]
id: GO:1903899
name: positive regulation of PERK-mediated unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "activation of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie]
synonym: "activation of PERK branch of UPR" NARROW [GOC:TermGenie]
synonym: "activation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "activation of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie]
synonym: "positive regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "positive regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "up regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "upregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "upregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response
relationship: positively_regulates GO:0036499 ! PERK-mediated unfolded protein response

[Term]
id: GO:1903900
name: regulation of viral life cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716]
synonym: "regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "regulation of viral replication" RELATED [GOC:TermGenie]
is_a: GO:0050792 ! regulation of viral process
relationship: regulates GO:0019058 ! viral life cycle

[Term]
id: GO:1903901
name: negative regulation of viral life cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716]
synonym: "down regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "down regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "down-regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "down-regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "downregulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "downregulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of viral replication" RELATED [GOC:TermGenie]
synonym: "inhibition of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "inhibition of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of viral life cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of viral replication" RELATED [GOC:TermGenie]
synonym: "negative regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral replication" RELATED [GOC:TermGenie]
is_a: GO:0048525 ! negative regulation of viral process
is_a: GO:1903900 ! regulation of viral life cycle
relationship: negatively_regulates GO:0019058 ! viral life cycle

[Term]
id: GO:1903902
name: positive regulation of viral life cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716]
synonym: "activation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "activation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "activation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "activation of viral life cycle" NARROW [GOC:TermGenie]
synonym: "activation of viral replication" RELATED [GOC:TermGenie]
synonym: "positive regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "up regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "up regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "up-regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "up-regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "upregulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "upregulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of viral replication" RELATED [GOC:TermGenie]
is_a: GO:0048524 ! positive regulation of viral process
is_a: GO:1903900 ! regulation of viral life cycle
relationship: positively_regulates GO:0019058 ! viral life cycle

[Term]
id: GO:1903903
name: regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:2000114 ! regulation of establishment of cell polarity
relationship: regulates GO:0001768 ! establishment of T cell polarity

[Term]
id: GO:1903904
name: negative regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050868 ! negative regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
relationship: negatively_regulates GO:0001768 ! establishment of T cell polarity

[Term]
id: GO:1903905
name: positive regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of T cell polarization" NARROW [GOC:TermGenie]
synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
relationship: positively_regulates GO:0001768 ! establishment of T cell polarity

[Term]
id: GO:1903906
name: regulation of plasma membrane raft polarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:1903729 ! regulation of plasma membrane organization
relationship: regulates GO:0044858 ! plasma membrane raft polarization

[Term]
id: GO:1903907
name: negative regulation of plasma membrane raft polarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "inhibition of plasma membrane raft polarization" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903906 ! regulation of plasma membrane raft polarization
relationship: negatively_regulates GO:0044858 ! plasma membrane raft polarization

[Term]
id: GO:1903908
name: positive regulation of plasma membrane raft polarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of plasma membrane raft polarization" NARROW [GOC:TermGenie]
synonym: "up regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903906 ! regulation of plasma membrane raft polarization
relationship: positively_regulates GO:0044858 ! plasma membrane raft polarization

[Term]
id: GO:1903909
name: regulation of receptor clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:0043113 ! receptor clustering

[Term]
id: GO:1903910
name: negative regulation of receptor clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor clustering" NARROW [GOC:TermGenie]
is_a: GO:1903909 ! regulation of receptor clustering
is_a: GO:1905476 ! negative regulation of protein localization to membrane
relationship: negatively_regulates GO:0043113 ! receptor clustering

[Term]
id: GO:1903911
name: positive regulation of receptor clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of receptor clustering" NARROW [GOC:TermGenie]
synonym: "up regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1903909 ! regulation of receptor clustering
is_a: GO:1905477 ! positive regulation of protein localization to membrane
relationship: positively_regulates GO:0043113 ! receptor clustering

[Term]
id: GO:1903912
name: negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "inhibition of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of eiF2alpha phosphorylation in response to ER stress" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT []
synonym: "negative regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf]
synonym: "negative regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
relationship: negatively_regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress

[Term]
id: GO:1903913
name: regulation of fusion of virus membrane with host plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "regulation of viral envelope fusion" BROAD [GOC:TermGenie]
synonym: "regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
is_a: GO:0046596 ! regulation of viral entry into host cell
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0019064 ! fusion of virus membrane with host plasma membrane

[Term]
id: GO:1903914
name: negative regulation of fusion of virus membrane with host plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "down regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "down regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "downregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "downregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "inhibition of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "inhibition of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral envelope fusion with host membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral penetration via membrane fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
is_a: GO:0048525 ! negative regulation of viral process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane
relationship: negatively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane
relationship: negatively_regulates GO:0046718 ! symbiont entry into host cell

[Term]
id: GO:1903915
name: positive regulation of fusion of virus membrane with host plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "activation of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral envelope fusion with host membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral penetration via membrane fusion" NARROW [GOC:TermGenie]
synonym: "activation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "up regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "up regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "upregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "upregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
is_a: GO:0046598 ! positive regulation of viral entry into host cell
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane
relationship: positively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane

[Term]
id: GO:1903916
name: obsolete regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT []
synonym: "regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf]
synonym: "regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903917
name: obsolete positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "activation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "activation of eIF2alpha dephosphorylation in response to ER stress" NARROW [GOC:TermGenie]
synonym: "activation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" RELATED []
synonym: "positive regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf]
synonym: "positive regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903918
name: regulation of actin filament severing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "regulation of F-actin severing" EXACT [GOC:TermGenie]
is_a: GO:0032970 ! regulation of actin filament-based process
relationship: regulates GO:0051014 ! actin filament severing

[Term]
id: GO:1903919
name: negative regulation of actin filament severing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "down regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "down regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "down regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "down regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "downregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "downregulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "inhibition of actin filament severing" NARROW [GOC:TermGenie]
synonym: "inhibition of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "inhibition of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "inhibition of F-actin severing" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of F-actin severing" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903918 ! regulation of actin filament severing
relationship: negatively_regulates GO:0051014 ! actin filament severing

[Term]
id: GO:1903920
name: positive regulation of actin filament severing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "activation of actin filament severing" NARROW [GOC:TermGenie]
synonym: "activation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "activation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "activation of F-actin severing" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "up regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "up regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "upregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "upregulation of F-actin severing" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903918 ! regulation of actin filament severing
relationship: positively_regulates GO:0051014 ! actin filament severing

[Term]
id: GO:1903921
name: regulation of protein processing in phagocytic vesicle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0070613 ! regulation of protein processing
relationship: regulates GO:1900756 ! protein processing in phagocytic vesicle

[Term]
id: GO:1903922
name: negative regulation of protein processing in phagocytic vesicle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "down regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "down regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "downregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "downregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "downregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "inhibition of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "inhibition of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "inhibition of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein processing in phagosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle
relationship: negatively_regulates GO:1900756 ! protein processing in phagocytic vesicle

[Term]
id: GO:1903923
name: positive regulation of protein processing in phagocytic vesicle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "activation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "activation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "activation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "activation of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein processing in phagosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "up regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "upregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "upregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "upregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0010954 ! positive regulation of protein processing
is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle
relationship: positively_regulates GO:1900756 ! protein processing in phagocytic vesicle

[Term]
id: GO:1903924
name: estradiol binding
namespace: molecular_function
def: "Binding to estradiol." [GO_REF:0000067, GOC:TermGenie, PMID:9048584]
is_a: GO:0005496 ! steroid binding

[Term]
id: GO:1903925
name: response to bisphenol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903926
name: cellular response to bisphenol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903925 ! response to bisphenol A

[Term]
id: GO:1903927
name: response to cyanide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1903928
name: cellular response to cyanide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1903927 ! response to cyanide

[Term]
id: GO:1903929
name: primary palate development
namespace: biological_process
def: "The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mgi_curators, GOC:TermGenie, PMID:24644145, PMID:25504820]
synonym: "palatum primarium development" RELATED [GOC:TermGenie]
synonym: "primary palate process development" EXACT [GOC:TermGenie]
synonym: "primitive palate development" RELATED [GOC:TermGenie]
synonym: "processus palatinus medianus development" RELATED [GOC:TermGenie]
is_a: GO:0060021 ! roof of mouth development

[Term]
id: GO:1903930
name: regulation of pyrimidine-containing compound salvage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302]
synonym: "regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
relationship: regulates GO:0008655 ! pyrimidine-containing compound salvage

[Term]
id: GO:1903931
name: positive regulation of pyrimidine-containing compound salvage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302]
synonym: "activation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "activation of pyrimidine-containing compound salvage" NARROW [GOC:TermGenie]
synonym: "positive regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "up-regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "upregulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:1903930 ! regulation of pyrimidine-containing compound salvage
relationship: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage

[Term]
id: GO:1903932
name: regulation of DNA primase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746]
subset: gocheck_obsoletion_candidate
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1903933
name: obsolete negative regulation of DNA primase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA primase activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903934
name: positive regulation of DNA primase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746]
subset: gocheck_obsoletion_candidate
synonym: "activation of DNA primase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA primase activity" EXACT [GOC:TermGenie]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1902680 ! positive regulation of RNA biosynthetic process
is_a: GO:1903932 ! regulation of DNA primase activity

[Term]
id: GO:1903935
name: response to sodium arsenite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524]
is_a: GO:0046685 ! response to arsenic-containing substance
is_a: GO:1902074 ! response to salt

[Term]
id: GO:1903936
name: cellular response to sodium arsenite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524]
is_a: GO:0071243 ! cellular response to arsenic-containing substance
is_a: GO:1902075 ! cellular response to salt
is_a: GO:1903935 ! response to sodium arsenite

[Term]
id: GO:1903937
name: response to acrylamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903938
name: cellular response to acrylamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903937 ! response to acrylamide

[Term]
id: GO:1903939
name: regulation of TORC2 signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430]
synonym: "regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032006 ! regulation of TOR signaling
relationship: regulates GO:0038203 ! TORC2 signaling

[Term]
id: GO:1903940
name: negative regulation of TORC2 signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430]
synonym: "down regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of TORC2 signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of TORC2 signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032007 ! negative regulation of TOR signaling
is_a: GO:1903939 ! regulation of TORC2 signaling
relationship: negatively_regulates GO:0038203 ! TORC2 signaling

[Term]
id: GO:1903941
name: negative regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system

[Term]
id: GO:1903942
name: positive regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie]
synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system

[Term]
id: GO:1903943
name: regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: regulates GO:0097284 ! hepatocyte apoptotic process

[Term]
id: GO:1903944
name: negative regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1903943 ! regulation of hepatocyte apoptotic process
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
relationship: negatively_regulates GO:0097284 ! hepatocyte apoptotic process

[Term]
id: GO:1903945
name: positive regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1903943 ! regulation of hepatocyte apoptotic process
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
relationship: positively_regulates GO:0097284 ! hepatocyte apoptotic process

[Term]
id: GO:1903946
name: negative regulation of ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential
is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction
relationship: negatively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential

[Term]
id: GO:1903947
name: positive regulation of ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential
is_a: GO:0106134 ! positive regulation of cardiac muscle cell contraction
relationship: positively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential

[Term]
id: GO:1903948
name: negative regulation of atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential
is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction
relationship: negatively_regulates GO:0086014 ! atrial cardiac muscle cell action potential

[Term]
id: GO:1903949
name: positive regulation of atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential
relationship: positively_regulates GO:0086014 ! atrial cardiac muscle cell action potential

[Term]
id: GO:1903950
name: negative regulation of AV node cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
relationship: negatively_regulates GO:0086016 ! AV node cell action potential

[Term]
id: GO:1903951
name: positive regulation of AV node cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
relationship: positively_regulates GO:0086016 ! AV node cell action potential

[Term]
id: GO:1903952
name: regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
subset: gocheck_obsoletion_candidate
synonym: "regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1903953
name: obsolete negative regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903954
name: obsolete positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1903955
name: positive regulation of protein targeting to mitochondrion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810]
comment: An example of this is PINK1 in human (UniProt symbol Q9BXM7) in PMID:24270810 inferred from mutant phenotype.
synonym: "activation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "activation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "activation of protein import into mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of protein targeting to mitochondria" NARROW [GOC:TermGenie]
synonym: "activation of protein targeting to mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of protein-mitochondrial targeting" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "up regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "up regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "up regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "upregulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "upregulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
is_a: GO:1903214 ! regulation of protein targeting to mitochondrion
is_a: GO:1903749 ! positive regulation of establishment of protein localization to mitochondrion
relationship: positively_regulates GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:1903958
name: nitric-oxide synthase complex
namespace: cellular_component
def: "A protein complex which is capable of nitric-oxide synthase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:25417112]
comment: An example of this is NOS2 in human (P35228) in PMID:25417112 (inferred from direct assay).
synonym: "iNOS-S100A8/A9 complex" NARROW []
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1903959
name: regulation of monoatomic anion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of anion transmembrane transport" BROAD []
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
is_a: GO:0044070 ! regulation of monoatomic anion transport
relationship: regulates GO:0098656 ! monoatomic anion transmembrane transport

[Term]
id: GO:1903960
name: negative regulation of anion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anion transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport
is_a: GO:1903792 ! negative regulation of monoatomic anion transport
is_a: GO:1903959 ! regulation of monoatomic anion transmembrane transport
relationship: negatively_regulates GO:0098656 ! monoatomic anion transmembrane transport

[Term]
id: GO:1903961
name: positive regulation of anion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport
is_a: GO:1903793 ! positive regulation of monoatomic anion transport
is_a: GO:1903959 ! regulation of monoatomic anion transmembrane transport
relationship: positively_regulates GO:0098656 ! monoatomic anion transmembrane transport

[Term]
id: GO:1903962
name: arachidonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arachidonate from one side of a membrane to the other." [GO_REF:0000066, GOC:bhm, GOC:TermGenie, PMID:15642721]
comment: An example of this is S100A9 in human (P06702) in PMID:15642721 (inferred from direct assay).
synonym: "arachidonate transporter activity" RELATED []
synonym: "arachidonic acid transporter activity" RELATED []
is_a: GO:0005324 ! long-chain fatty acid transmembrane transporter activity

[Term]
id: GO:1903963
name: arachidonate transport
namespace: biological_process
def: "The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:bhm, GOC:TermGenie, PMID:15642721]
synonym: "arachidonic acid transport" EXACT []
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:1903964
name: monounsaturated fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast.
synonym: "monounsaturated fatty acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:1903965
name: monounsaturated fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
synonym: "monounsaturated fatty acid breakdown" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid catabolism" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:1903964 ! monounsaturated fatty acid metabolic process

[Term]
id: GO:1903966
name: monounsaturated fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast.
synonym: "monounsaturated fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid formation" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:1903964 ! monounsaturated fatty acid metabolic process

[Term]
id: GO:1903967
name: response to micafungin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959]
is_a: GO:0033993 ! response to lipid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1903968
name: cellular response to micafungin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903967 ! response to micafungin

[Term]
id: GO:1903969
name: regulation of response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: regulates GO:0036005 ! response to macrophage colony-stimulating factor

[Term]
id: GO:1903970
name: negative regulation of response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "down regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "downregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "downregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of response to M-CSF" NARROW [GOC:TermGenie]
synonym: "inhibition of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "inhibition of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor
relationship: negatively_regulates GO:0036005 ! response to macrophage colony-stimulating factor

[Term]
id: GO:1903971
name: positive regulation of response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of response to M-CSF" NARROW [GOC:TermGenie]
synonym: "activation of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "activation of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "up regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "upregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "upregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor
relationship: positively_regulates GO:0036005 ! response to macrophage colony-stimulating factor

[Term]
id: GO:1903972
name: regulation of cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor
relationship: regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus

[Term]
id: GO:1903973
name: negative regulation of cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
is_a: GO:1903970 ! negative regulation of response to macrophage colony-stimulating factor
is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus
relationship: negatively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus

[Term]
id: GO:1903974
name: positive regulation of cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:1903971 ! positive regulation of response to macrophage colony-stimulating factor
is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus
relationship: positively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus

[Term]
id: GO:1903975
name: regulation of glial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0008347 ! glial cell migration

[Term]
id: GO:1903976
name: negative regulation of glial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
relationship: negatively_regulates GO:0008347 ! glial cell migration

[Term]
id: GO:1903977
name: positive regulation of glial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of glia cell migration" NARROW [GOC:TermGenie]
synonym: "activation of glial cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
relationship: positively_regulates GO:0008347 ! glial cell migration

[Term]
id: GO:1903978
name: regulation of microglial cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0043030 ! regulation of macrophage activation
is_a: GO:0150077 ! regulation of neuroinflammatory response
relationship: regulates GO:0001774 ! microglial cell activation

[Term]
id: GO:1903979
name: negative regulation of microglial cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell activation" NARROW [GOC:TermGenie]
is_a: GO:0043031 ! negative regulation of macrophage activation
is_a: GO:0150079 ! negative regulation of neuroinflammatory response
is_a: GO:1903978 ! regulation of microglial cell activation
relationship: negatively_regulates GO:0001774 ! microglial cell activation

[Term]
id: GO:1903980
name: positive regulation of microglial cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell activation" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell activation" EXACT [GOC:TermGenie]
is_a: GO:0043032 ! positive regulation of macrophage activation
is_a: GO:0150078 ! positive regulation of neuroinflammatory response
is_a: GO:1903978 ! regulation of microglial cell activation
relationship: positively_regulates GO:0001774 ! microglial cell activation

[Term]
id: GO:1903981
name: enterobactin binding
namespace: molecular_function
def: "Binding to enterobactin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132]
synonym: "enterochelin binding" EXACT []
synonym: "siderophore binding" BROAD []
is_a: GO:0005527 ! macrolide binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:1903982
name: negative regulation of microvillus length
namespace: biological_process
def: "A process that decreases the length of a microvillus." [GOC:als, PMID:22114352]
synonym: "down regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of microvillus length" NARROW [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0032532 ! regulation of microvillus length

[Term]
id: GO:1903983
name: positive regulation of microvillus length
namespace: biological_process
def: "A process that increases the length of a microvillus." [GOC:als, PMID:22114352]
synonym: "activation of regulation of microvillus length" NARROW [GOC:TermGenie]
synonym: "up regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of microvillus length" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0032532 ! regulation of microvillus length

[Term]
id: GO:1903984
name: positive regulation of TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24939851]
synonym: "activation of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902043 ! positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway
relationship: positively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway

[Term]
id: GO:1903985
name: regulation of intestinal D-glucose absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal D-glucose absorption." [GO_REF:0000058, GOA:als, GOC:TermGenie, PMID:22114352]
is_a: GO:1904478 ! regulation of intestinal absorption
relationship: regulates GO:0001951 ! intestinal D-glucose absorption

[Term]
id: GO:1903988
name: iron ion export across plasma membrane
namespace: biological_process
alt_id: GO:1903414
def: "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000074, GOC:BHF, GOC:kom, GOC:rl, GOC:TermGenie, PMID:15514116]
comment: An example of this is mouse ferroportin (symbol Slc40a1, UniProtKB identifier: Q9JHI9).
synonym: "ferrous iron export" NARROW []
synonym: "ferrous iron export across plasma membrane" NARROW []
synonym: "iron cation export" RELATED []
synonym: "iron(2+) export" RELATED []
is_a: GO:0034755 ! iron ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:1903992
name: obsolete regulation of protein stabilization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880]
comment: This term was made obsolete because it was created in error.
synonym: "regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "regulation of protein stabilization" EXACT []
synonym: "regulation of protein stabilization activity" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0031647

[Term]
id: GO:1903993
name: obsolete negative regulation of protein stabilization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880]
comment: This term was made obsolete because it was created in error.
synonym: "down regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "down regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "down regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "down regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "down-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "downregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "downregulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "downregulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "downregulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "inhibition of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "inhibition of positive regulation of protein stability" NARROW [GOC:TermGenie]
synonym: "inhibition of protein sequestering" RELATED [GOC:TermGenie]
synonym: "inhibition of protein stabilization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "negative regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein stabilization" EXACT []
synonym: "negative regulation of protein stabilization activity" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0031648

[Term]
id: GO:1903994
name: obsolete positive regulation of protein stabilization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880]
comment: This term was made obsolete because it was created in error.
synonym: "activation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "activation of positive regulation of protein stability" NARROW [GOC:TermGenie]
synonym: "activation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "activation of protein stabilization" NARROW [GOC:TermGenie]
synonym: "activation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "positive regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein stabilization" EXACT []
synonym: "positive regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "up regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "up regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "up regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "up regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "up-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "upregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "upregulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "upregulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "upregulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein stabilization activity" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0050821

[Term]
id: GO:1903995
name: regulation of non-membrane spanning protein tyrosine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:protein-tyrosine O-phosphotransferase activity" BROAD [GOC:TermGenie]
synonym: "regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity

[Term]
id: GO:1903996
name: negative regulation of non-membrane spanning protein tyrosine kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity
is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity

[Term]
id: GO:1903997
name: positive regulation of non-membrane spanning protein tyrosine kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]
subset: gocheck_obsoletion_candidate
synonym: "activation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie]
synonym: "activation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "activation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "activation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "activation of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity
is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity

[Term]
id: GO:1903998
name: regulation of eating behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051]
synonym: "regulation of eating behaviour" EXACT [GOC:TermGenie]
is_a: GO:0060259 ! regulation of feeding behavior
relationship: regulates GO:0042755 ! eating behavior

[Term]
id: GO:1903999
name: negative regulation of eating behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051]
synonym: "down regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "down regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "down-regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "down-regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "downregulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "downregulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "inhibition of eating behavior" NARROW [GOC:TermGenie]
synonym: "inhibition of eating behaviour" NARROW [GOC:TermGenie]
synonym: "negative regulation of eating behaviour" EXACT [GOC:TermGenie]
is_a: GO:1903998 ! regulation of eating behavior
is_a: GO:2000252 ! negative regulation of feeding behavior
relationship: negatively_regulates GO:0042755 ! eating behavior

[Term]
id: GO:1904000
name: positive regulation of eating behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051]
synonym: "activation of eating behavior" NARROW [GOC:TermGenie]
synonym: "activation of eating behaviour" NARROW [GOC:TermGenie]
synonym: "positive regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "up regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "up regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "up-regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "up-regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "upregulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "upregulation of eating behaviour" EXACT [GOC:TermGenie]
is_a: GO:1903998 ! regulation of eating behavior
is_a: GO:2000253 ! positive regulation of feeding behavior
relationship: positively_regulates GO:0042755 ! eating behavior

[Term]
id: GO:1904001
name: obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [GO_REF:0000063, GOC:al, GOC:TermGenie, PMID:23695302]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "activation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up-regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "upregulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904002
name: regulation of sebum secreting cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]
synonym: "regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:1990654 ! sebum secreting cell proliferation

[Term]
id: GO:1904003
name: negative regulation of sebum secreting cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]
synonym: "down regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "down regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "down-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "downregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "inhibition of sebum secreting cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1904002 ! regulation of sebum secreting cell proliferation
relationship: negatively_regulates GO:1990654 ! sebum secreting cell proliferation

[Term]
id: GO:1904004
name: positive regulation of sebum secreting cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]
synonym: "activation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "activation of sebum secreting cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "up-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "upregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1904002 ! regulation of sebum secreting cell proliferation
relationship: positively_regulates GO:1990654 ! sebum secreting cell proliferation

[Term]
id: GO:1904005
name: regulation of phospholipase D activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872]
subset: gocheck_obsoletion_candidate
synonym: "regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0010517 ! regulation of phospholipase activity

[Term]
id: GO:1904006
name: obsolete negative regulation of phospholipase D activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "down regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "inhibition of choline phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lecithinase D activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lipophosphodiesterase II activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipase D activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904007
name: obsolete positive regulation of phospholipase D activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of choline phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of lecithinase D activity" NARROW [GOC:TermGenie]
synonym: "activation of lipophosphodiesterase II activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of phospholipase D activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "up regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "upregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipase D activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904008
name: obsolete response to monosodium glutamate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590]
comment: This term was obsoleted because GCI patterns make it equivalent to response to L-glutamate; GO:1902065.
is_obsolete: true
consider: GO:1902065

[Term]
id: GO:1904009
name: obsolete cellular response to monosodium glutamate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590]
comment: This term was obsoleted because GCI patterns make it equivalent to cellular response to L-glutamate; GO:1905232.
is_obsolete: true
consider: GO:1905232

[Term]
id: GO:1904010
name: response to Aroclor 1254
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1904011
name: cellular response to Aroclor 1254
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904010 ! response to Aroclor 1254

[Term]
id: GO:1904012
name: obsolete platinum binding
namespace: molecular_function
def: "OBSOLETE. Binding to platinum." [GO_REF:0000067, GOC:TermGenie, PMID:10089464]
comment: The reason for obsoletion is that binding to platinum does not have physiological relevance.
is_obsolete: true

[Term]
id: GO:1904013
name: obsolete xenon atom binding
namespace: molecular_function
def: "OBSOLETE. Binding to xenon atom." [GO_REF:0000067, GOC:TermGenie, PMID:10089464]
comment: The reason for obsoletion is that binding to xenon does not have physiological relevance.
is_obsolete: true

[Term]
id: GO:1904014
name: response to serotonin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904015
name: cellular response to serotonin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071868 ! cellular response to monoamine stimulus
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904014 ! response to serotonin

[Term]
id: GO:1904016
name: response to Thyroglobulin triiodothyronine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1904017
name: cellular response to Thyroglobulin triiodothyronine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904016 ! response to Thyroglobulin triiodothyronine

[Term]
id: GO:1904018
name: positive regulation of vasculature development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453]
synonym: "activation of vascular system development" RELATED [GOC:TermGenie]
synonym: "activation of vasculature development" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
relationship: positively_regulates GO:0001944 ! vasculature development

[Term]
id: GO:1904019
name: epithelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015]
synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:1904020
name: regulation of G protein-coupled receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013]
synonym: "regulation of G-protein-coupled receptor internalization" EXACT []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0002031 ! G protein-coupled receptor internalization

[Term]
id: GO:1904021
name: negative regulation of G protein-coupled receptor internalization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013]
synonym: "down regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein coupled receptor internalization" NARROW [GOC:TermGenie]
synonym: "negative regulation of G-protein coupled receptor internalization" EXACT []
is_a: GO:0002091 ! negative regulation of receptor internalization
is_a: GO:1904020 ! regulation of G protein-coupled receptor internalization
relationship: negatively_regulates GO:0002031 ! G protein-coupled receptor internalization

[Term]
id: GO:1904022
name: positive regulation of G protein-coupled receptor internalization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013]
synonym: "activation of G-protein coupled receptor internalization" NARROW [GOC:TermGenie]
synonym: "positive regulation of G-protein coupled receptor internalization" EXACT []
synonym: "up regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
is_a: GO:0002092 ! positive regulation of receptor internalization
is_a: GO:1904020 ! regulation of G protein-coupled receptor internalization
relationship: positively_regulates GO:0002031 ! G protein-coupled receptor internalization

[Term]
id: GO:1904023
name: regulation of glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]
synonym: "regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "regulation of homolactic fermentation" EXACT [GOC:TermGenie]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0043465 ! regulation of fermentation
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate

[Term]
id: GO:1904024
name: negative regulation of glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]
synonym: "down regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "down regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "down regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "down regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down-regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "downregulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "inhibition of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "inhibition of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "inhibition of homofermentation" NARROW [GOC:TermGenie]
synonym: "inhibition of homofermentative lactate fermentation" NARROW [GOC:TermGenie]
synonym: "inhibition of homofermentative pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of homolactate fermentation" NARROW [GOC:TermGenie]
synonym: "inhibition of homolactic fermentation" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "negative regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homolactic fermentation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901003 ! negative regulation of fermentation
is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate
relationship: negatively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate

[Term]
id: GO:1904025
name: positive regulation of glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]
synonym: "activation of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "activation of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "activation of homofermentation" NARROW [GOC:TermGenie]
synonym: "activation of homofermentative lactate fermentation" NARROW [GOC:TermGenie]
synonym: "activation of homofermentative pathway" NARROW [GOC:TermGenie]
synonym: "activation of homolactate fermentation" NARROW [GOC:TermGenie]
synonym: "activation of homolactic fermentation" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "positive regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up-regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "upregulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of homolactic fermentation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate
relationship: positively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate

[Term]
id: GO:1904026
name: regulation of collagen fibril organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "regulation of collagen fibrillogenesis" RELATED []
synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1902903 ! regulation of supramolecular fiber organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
relationship: regulates GO:0030199 ! collagen fibril organization

[Term]
id: GO:1904027
name: negative regulation of collagen fibril organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
relationship: negatively_regulates GO:0030199 ! collagen fibril organization

[Term]
id: GO:1904028
name: positive regulation of collagen fibril organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
relationship: positively_regulates GO:0030199 ! collagen fibril organization

[Term]
id: GO:1904029
name: regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]
subset: gocheck_obsoletion_candidate
is_a: GO:0045859 ! regulation of protein kinase activity
is_a: GO:0051726 ! regulation of cell cycle

[Term]
id: GO:1904030
name: negative regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:1904031
name: positive regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]
subset: gocheck_obsoletion_candidate
synonym: "activation of cyclin-dependent protein kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0045860 ! positive regulation of protein kinase activity
is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:1904032
name: regulation of t-SNARE clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485]
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:1990656 ! t-SNARE clustering

[Term]
id: GO:1904033
name: negative regulation of t-SNARE clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485]
synonym: "down regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of t-SNARE clustering" NARROW [GOC:TermGenie]
is_a: GO:1904032 ! regulation of t-SNARE clustering
is_a: GO:1905476 ! negative regulation of protein localization to membrane
relationship: negatively_regulates GO:1990656 ! t-SNARE clustering

[Term]
id: GO:1904034
name: positive regulation of t-SNARE clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485]
synonym: "activation of t-SNARE clustering" NARROW [GOC:TermGenie]
synonym: "up regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of t-SNARE clustering" EXACT [GOC:TermGenie]
is_a: GO:1904032 ! regulation of t-SNARE clustering
is_a: GO:1905477 ! positive regulation of protein localization to membrane
relationship: positively_regulates GO:1990656 ! t-SNARE clustering

[Term]
id: GO:1904035
name: regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1904036
name: negative regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: negatively_regulates GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1904037
name: positive regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: positively_regulates GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1904038
name: regulation of iron export across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "regulation of ferrous iron export" NARROW []
synonym: "regulation of iron(2+) export" NARROW []
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
relationship: regulates GO:1903988 ! iron ion export across plasma membrane

[Term]
id: GO:1904039
name: negative regulation of iron export across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "down regulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "down regulation of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "down-regulation of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "downregulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "downregulation of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "inhibition of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron(2+) export" NARROW []
is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport
is_a: GO:1904038 ! regulation of iron export across plasma membrane
relationship: negatively_regulates GO:1903988 ! iron ion export across plasma membrane

[Term]
id: GO:1904040
name: positive regulation of iron export across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "activation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "activation of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron(2+) export" NARROW []
synonym: "up regulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "up regulation of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "up-regulation of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "upregulation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "upregulation of iron(2+) export" NARROW [GOC:TermGenie]
is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport
is_a: GO:1904038 ! regulation of iron export across plasma membrane
relationship: positively_regulates GO:1903988 ! iron ion export across plasma membrane

[Term]
id: GO:1904041
name: regulation of cystathionine beta-synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]
subset: gocheck_obsoletion_candidate
synonym: "regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:1904042
name: negative regulation of cystathionine beta-synthase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "down regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "downregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-thionase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cystathionine beta-synthase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie]
synonym: "inhibition of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of methylcysteine synthase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine sulfhydrase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine sulfhydrylase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051350 ! negative regulation of lyase activity
is_a: GO:1904041 ! regulation of cystathionine beta-synthase activity

[Term]
id: GO:1904043
name: obsolete positive regulation of cystathionine beta-synthase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of beta-thionase activity" NARROW [GOC:TermGenie]
synonym: "activation of cystathionine beta-synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie]
synonym: "activation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie]
synonym: "activation of methylcysteine synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of serine sulfhydrase activity" NARROW [GOC:TermGenie]
synonym: "activation of serine sulfhydrylase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "up regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "upregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904044
name: response to aldosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563]
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1904045
name: cellular response to aldosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563]
is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:0110096 ! cellular response to aldehyde
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904044 ! response to aldosterone

[Term]
id: GO:1904046
name: negative regulation of vascular endothelial growth factor production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production." [GO_REF:0000058, GOC:TermGenie, PMID:19404486]
synonym: "down regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie]
synonym: "down regulation of VEGF production" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie]
synonym: "down-regulation of VEGF production" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie]
synonym: "downregulation of VEGF production" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular endothelial growth factor production" NARROW [GOC:TermGenie]
synonym: "inhibition of VEGF production" NARROW [GOC:TermGenie]
synonym: "negative regulation of VEGF production" EXACT [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0010574 ! regulation of vascular endothelial growth factor production
relationship: negatively_regulates GO:0010573 ! vascular endothelial growth factor production

[Term]
id: GO:1904047
name: S-adenosyl-L-methionine binding
namespace: molecular_function
alt_id: GO:0070283
def: "Binding to S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]
synonym: "radical SAM enzyme activity" NARROW []
xref: Reactome:R-HSA-947535 "Cyclisation of GTP to precursor Z"
is_a: GO:0043169 ! cation binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:1904048
name: regulation of spontaneous neurotransmitter secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]
comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
synonym: "regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0150003 ! regulation of spontaneous synaptic transmission
relationship: regulates GO:0061669 ! spontaneous neurotransmitter secretion

[Term]
id: GO:1904049
name: negative regulation of spontaneous neurotransmitter secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]
comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
synonym: "down regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion
relationship: negatively_regulates GO:0061669 ! spontaneous neurotransmitter secretion

[Term]
id: GO:1904050
name: positive regulation of spontaneous neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]
comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
synonym: "activation of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "activation of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion
relationship: positively_regulates GO:0061669 ! spontaneous neurotransmitter secretion

[Term]
id: GO:1904051
name: regulation of protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype).
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903533 ! regulation of protein targeting
relationship: regulates GO:0071211 ! protein targeting to vacuole involved in autophagy

[Term]
id: GO:1904052
name: negative regulation of protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype).
synonym: "down regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie]
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1903336 ! negative regulation of vacuolar transport
is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy
relationship: negatively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy

[Term]
id: GO:1904053
name: positive regulation of protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype).
synonym: "activation of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie]
synonym: "up regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903337 ! positive regulation of vacuolar transport
is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy
relationship: positively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy

[Term]
id: GO:1904054
name: regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:1990705 ! cholangiocyte proliferation

[Term]
id: GO:1904055
name: negative regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904054 ! regulation of cholangiocyte proliferation
relationship: negatively_regulates GO:1990705 ! cholangiocyte proliferation

[Term]
id: GO:1904056
name: positive regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904054 ! regulation of cholangiocyte proliferation
relationship: positively_regulates GO:1990705 ! cholangiocyte proliferation

[Term]
id: GO:1904057
name: negative regulation of sensory perception of pain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "down regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "down-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "downregulation of nociception" EXACT [GOC:TermGenie]
synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "inhibition of nociception" NARROW [GOC:TermGenie]
synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "negative regulation of nociception" EXACT [GOC:TermGenie]
synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0051930 ! regulation of sensory perception of pain
relationship: negatively_regulates GO:0019233 ! sensory perception of pain

[Term]
id: GO:1904058
name: positive regulation of sensory perception of pain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "activation of nociception" NARROW [GOC:TermGenie]
synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "positive regulation of nociception" EXACT [GOC:TermGenie]
synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "up-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "upregulation of nociception" EXACT [GOC:TermGenie]
synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0051930 ! regulation of sensory perception of pain
relationship: positively_regulates GO:0019233 ! sensory perception of pain

[Term]
id: GO:1904059
name: regulation of locomotor rhythm
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969]
synonym: "regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0045475 ! locomotor rhythm

[Term]
id: GO:1904060
name: negative regulation of locomotor rhythm
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969]
synonym: "down regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "down regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "down-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "down-regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "downregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "downregulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "inhibition of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "inhibition of locomotor rhythm" NARROW [GOC:TermGenie]
synonym: "negative regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
is_a: GO:0042754 ! negative regulation of circadian rhythm
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1904059 ! regulation of locomotor rhythm
relationship: negatively_regulates GO:0045475 ! locomotor rhythm

[Term]
id: GO:1904061
name: positive regulation of locomotor rhythm
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969]
synonym: "activation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "activation of locomotor rhythm" NARROW [GOC:TermGenie]
synonym: "positive regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "up regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "up regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "up-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "up-regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "upregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "upregulation of locomotor rhythm" EXACT [GOC:TermGenie]
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1904059 ! regulation of locomotor rhythm
relationship: positively_regulates GO:0045475 ! locomotor rhythm

[Term]
id: GO:1904062
name: regulation of monoatomic cation transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "regulation of cation transmembrane transport" BROAD []
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
relationship: regulates GO:0098655 ! monoatomic cation transmembrane transport

[Term]
id: GO:1904063
name: negative regulation of cation transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: negatively_regulates GO:0098655 ! monoatomic cation transmembrane transport

[Term]
id: GO:1904064
name: positive regulation of cation transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
relationship: positively_regulates GO:0098655 ! monoatomic cation transmembrane transport

[Term]
id: GO:1904065
name: G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT []
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway
relationship: part_of GO:0014057 ! positive regulation of acetylcholine secretion, neurotransmission

[Term]
id: GO:1904066
name: G protein-coupled receptor signaling pathway involved in dauer larval development
namespace: biological_process
def: "Any G protein-coupled receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:22665789]
synonym: "G protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:1904067
name: ascr#2 binding
namespace: molecular_function
def: "Binding to ascr#2." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:22665789]
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:1904068
name: G protein-coupled receptor signaling pathway involved in social behavior
namespace: biological_process
def: "Any G protein-coupled receptor signaling pathway that is involved in social behavior." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:22665789]
synonym: "G protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in social behavior" EXACT []
synonym: "G-protein coupled receptor signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
relationship: part_of GO:0035176 ! social behavior

[Term]
id: GO:1904069
name: ascaroside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, PMID:25775534]
synonym: "ascaroside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:1904070
name: ascaroside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, PMID:25775534]
synonym: "ascaroside anabolism" EXACT [GOC:TermGenie]
synonym: "ascaroside biosynthesis" EXACT [GOC:TermGenie]
synonym: "ascaroside formation" EXACT [GOC:TermGenie]
synonym: "ascaroside synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:1904069 ! ascaroside metabolic process

[Term]
id: GO:1904071
name: presynaptic active zone assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GO_REF:0000079, GOC:pr, GOC:TermGenie, PMID:10769383]
synonym: "pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "presynaptic active zone formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1990709 ! presynaptic active zone organization
relationship: part_of GO:0099054 ! presynapse assembly

[Term]
id: GO:1904072
name: presynaptic active zone disassembly
namespace: biological_process
def: "The disaggregation of a presynaptic active zone into its constituent components." [GO_REF:0000079, GOC:pr, GOC:TermGenie, ISBN:9780387325606]
synonym: "pre-synaptic active zone component disassembly" NARROW [GOC:TermGenie]
synonym: "pre-synaptic active zone disassembly" EXACT [GOC:TermGenie]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:1990709 ! presynaptic active zone organization

[Term]
id: GO:1904073
name: regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0001834 ! trophectodermal cell proliferation

[Term]
id: GO:1904074
name: negative regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
relationship: negatively_regulates GO:0001834 ! trophectodermal cell proliferation

[Term]
id: GO:1904075
name: positive regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
relationship: positively_regulates GO:0001834 ! trophectodermal cell proliferation

[Term]
id: GO:1904076
name: regulation of estrogen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842]
synonym: "regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0006703 ! estrogen biosynthetic process

[Term]
id: GO:1904077
name: negative regulation of estrogen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842]
synonym: "down regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of estrogen anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen formation" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of oestrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of oestrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:1904076 ! regulation of estrogen biosynthetic process
relationship: negatively_regulates GO:0006703 ! estrogen biosynthetic process

[Term]
id: GO:1904078
name: positive regulation of estrogen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842]
synonym: "activation of estrogen anabolism" NARROW [GOC:TermGenie]
synonym: "activation of estrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of estrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of estrogen formation" NARROW [GOC:TermGenie]
synonym: "activation of estrogen synthesis" NARROW [GOC:TermGenie]
synonym: "activation of oestrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of oestrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:1904076 ! regulation of estrogen biosynthetic process
relationship: positively_regulates GO:0006703 ! estrogen biosynthetic process

[Term]
id: GO:1904079
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process
namespace: biological_process
def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in negative regulation of neuron apoptotic process." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:20150917]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT []
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in neuron survival" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122
consider: GO:0043524

[Term]
id: GO:1904080
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in neuron fate specification
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron fate specification." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:11959845]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0045944
consider: GO:0048665

[Term]
id: GO:1904081
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:24353061]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0030182
consider: GO:0045944

[Term]
id: GO:1904082
name: pyrimidine nucleobase transmembrane transport
namespace: biological_process
def: "The process in which pyrimidine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie]
is_a: GO:0015855 ! pyrimidine nucleobase transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport

[Term]
id: GO:1904083
name: obsolete regulation of epiboly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of epiboly" EXACT []
is_obsolete: true

[Term]
id: GO:1904084
name: obsolete negative regulation of epiboly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "down-regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "downregulation of epiboly" EXACT [GOC:TermGenie]
synonym: "inhibition of epiboly" NARROW [GOC:TermGenie]
synonym: "negative regulation of epiboly" EXACT []
is_obsolete: true

[Term]
id: GO:1904085
name: obsolete positive regulation of epiboly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of epiboly" NARROW [GOC:TermGenie]
synonym: "positive regulation of epiboly" EXACT []
synonym: "up regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "up-regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "upregulation of epiboly" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904086
name: regulation of epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second

[Term]
id: GO:1904087
name: negative regulation of epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "down-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "downregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "inhibition of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie]
is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second

[Term]
id: GO:1904088
name: positive regulation of epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
synonym: "activation of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie]
synonym: "up regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "up-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "upregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second

[Term]
id: GO:1904089
name: obsolete negative regulation of neuron apoptotic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of neuron apoptotic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:20150917]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of neuron apoptosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of programmed cell death, neurons by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:1904090
name: peptidase inhibitor complex
namespace: cellular_component
def: "A protein complex which is capable of peptidase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624]
comment: An example of this is Cystatin-A in human (UniProt symbol P01040) in PMID:20860624 (inferred from physical interaction).
synonym: "Cathepsin-B - cystatin-A complex" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1904091
name: non-ribosomal peptide synthetase activity
namespace: molecular_function
def: "Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization." [PMID:10631508, PMID:17502372]
comment: Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.
synonym: "PCP" RELATED []
synonym: "peptidyl carrier protein" RELATED [GOC:pr]
synonym: "peptidyl carrier protein activity" RELATED []
synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis" EXACT []
synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:1904092
name: regulation of autophagic cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
synonym: "regulation of autophagic death" BROAD [GOC:TermGenie]
synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie]
synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0043067 ! regulation of programmed cell death
relationship: regulates GO:0048102 ! autophagic cell death

[Term]
id: GO:1904093
name: negative regulation of autophagic cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
synonym: "down regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "down regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "down-regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "downregulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "inhibition of autophagic cell death" NARROW [GOC:TermGenie]
synonym: "inhibition of programmed cell death by macroautophagy" NARROW [GOC:TermGenie]
synonym: "inhibition of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "negative regulation of type II programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:1904092 ! regulation of autophagic cell death
relationship: negatively_regulates GO:0048102 ! autophagic cell death

[Term]
id: GO:1904094
name: positive regulation of autophagic cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
synonym: "activation of autophagic cell death" NARROW [GOC:TermGenie]
synonym: "activation of programmed cell death by macroautophagy" NARROW [GOC:TermGenie]
synonym: "activation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "positive regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "up regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "up regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "up-regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "upregulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of type II programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:1904092 ! regulation of autophagic cell death
relationship: positively_regulates GO:0048102 ! autophagic cell death

[Term]
id: GO:1904095
name: negative regulation of endosperm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosperm development." [GO_REF:0000058, GOC:TermGenie, PMID:25194028]
synonym: "down regulation of endosperm development" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosperm development" EXACT [GOC:TermGenie]
synonym: "downregulation of endosperm development" EXACT [GOC:TermGenie]
synonym: "inhibition of endosperm development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000014 ! regulation of endosperm development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0009960 ! endosperm development

[Term]
id: GO:1904096
name: protein tyrosine phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of protein tyrosine phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22389722]
comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction).
is_a: GO:1903293 ! phosphatase complex

[Term]
id: GO:1904097
name: acid phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of acid phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:8132635]
comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction).
is_a: GO:1903293 ! phosphatase complex

[Term]
id: GO:1904098
name: regulation of protein O-linked glycosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
is_a: GO:0060049 ! regulation of protein glycosylation
relationship: regulates GO:0006493 ! protein O-linked glycosylation

[Term]
id: GO:1904099
name: negative regulation of protein O-linked glycosylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
is_a: GO:0060051 ! negative regulation of protein glycosylation
is_a: GO:1904098 ! regulation of protein O-linked glycosylation
relationship: negatively_regulates GO:0006493 ! protein O-linked glycosylation

[Term]
id: GO:1904100
name: positive regulation of protein O-linked glycosylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "activation of protein O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
is_a: GO:0060050 ! positive regulation of protein glycosylation
is_a: GO:1904098 ! regulation of protein O-linked glycosylation
relationship: positively_regulates GO:0006493 ! protein O-linked glycosylation

[Term]
id: GO:1904101
name: response to acadesine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904102
name: cellular response to acadesine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904101 ! response to acadesine

[Term]
id: GO:1904103
name: regulation of convergent extension involved in gastrulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:1904104
name: negative regulation of convergent extension involved in gastrulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in gastrulation" NARROW [GOC:TermGenie]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:1904105
name: positive regulation of convergent extension involved in gastrulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in gastrulation" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:1904106
name: protein localization to microvillus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie]
synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie]
synonym: "protein localization in microvillus" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1904107
name: protein localization to microvillus membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a microvillus membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in microvillus membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to microvillus membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in microvillus membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1904106 ! protein localization to microvillus
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1904108
name: protein localization to ciliary inversin compartment
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in ciliary inversin compartment" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary inversin compartment" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary inversin compartment" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium

[Term]
id: GO:1904109
name: positive regulation of cholesterol import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholesterol import." [GO_REF:0000058, GOC:TermGenie, PMID:16772292]
synonym: "activation of cholesterol import" NARROW [GOC:TermGenie]
synonym: "activation of cholesterol uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of cholesterol uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of cholesterol import" EXACT [GOC:TermGenie]
synonym: "up regulation of cholesterol uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholesterol import" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholesterol uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of cholesterol import" EXACT [GOC:TermGenie]
synonym: "upregulation of cholesterol uptake" EXACT [GOC:TermGenie]
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:0060620 ! regulation of cholesterol import
relationship: positively_regulates GO:0070508 ! cholesterol import

[Term]
id: GO:1904110
name: obsolete regulation of plus-end directed microfilament motor activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0140659

[Term]
id: GO:1904111
name: obsolete negative regulation of plus-end directed microfilament motor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "down regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "downregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "inhibition of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0140661

[Term]
id: GO:1904112
name: obsolete positive regulation of plus-end directed microfilament motor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "activation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "activation of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "activation of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "upregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0140659

[Term]
id: GO:1904113
name: negative regulation of muscle filament sliding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181]
synonym: "down regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "down-regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "downregulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "inhibition of muscle filament sliding" NARROW [GOC:TermGenie]
is_a: GO:0032971 ! regulation of muscle filament sliding
is_a: GO:0045932 ! negative regulation of muscle contraction
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0030049 ! muscle filament sliding

[Term]
id: GO:1904114
name: positive regulation of muscle filament sliding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181]
synonym: "activation of muscle filament sliding" NARROW [GOC:TermGenie]
synonym: "up regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "up-regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "upregulation of muscle filament sliding" EXACT [GOC:TermGenie]
is_a: GO:0032971 ! regulation of muscle filament sliding
is_a: GO:1903116 ! positive regulation of actin filament-based movement
relationship: positively_regulates GO:0030049 ! muscle filament sliding

[Term]
id: GO:1904115
name: axon cytoplasm
namespace: cellular_component
def: "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152]
synonym: "axoplasm" EXACT []
is_a: GO:0120111 ! neuron projection cytoplasm
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:1904116
name: response to vasopressin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:1904117
name: cellular response to vasopressin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1904116 ! response to vasopressin

[Term]
id: GO:1904118
name: regulation of otic vesicle morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106]
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0071600 ! otic vesicle morphogenesis

[Term]
id: GO:1904119
name: negative regulation of otic vesicle morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106]
synonym: "down regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of otic vesicle morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0110111 ! negative regulation of animal organ morphogenesis
is_a: GO:1904118 ! regulation of otic vesicle morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0071600 ! otic vesicle morphogenesis

[Term]
id: GO:1904120
name: positive regulation of otic vesicle morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106]
synonym: "activation of otic vesicle morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
is_a: GO:1904118 ! regulation of otic vesicle morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0071600 ! otic vesicle morphogenesis

[Term]
id: GO:1904121
name: phosphatidylethanolamine transfer activity
namespace: molecular_function
def: "Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GO_REF:0000066, GOC:TermGenie, PMID:8606365]
synonym: "intermembrane phosphatidylethanolamine transfer activity" NARROW []
synonym: "phosphatidylethanolamine carrier activity" EXACT []
synonym: "phosphatidylethanolamine transporter activity" BROAD []
is_a: GO:0120014 ! phospholipid transfer activity

[Term]
id: GO:1904122
name: positive regulation of fatty acid beta-oxidation by octopamine signaling pathway
namespace: biological_process
def: "An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942]
synonym: "activation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation
is_a: GO:0071927 ! octopamine signaling pathway

[Term]
id: GO:1904123
name: positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway
namespace: biological_process
def: "A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942]
synonym: "activation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0007210 ! serotonin receptor signaling pathway
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation

[Term]
id: GO:1904124
name: microglial cell migration
namespace: biological_process
def: "The orderly movement of a microglial cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0008347 ! glial cell migration
is_a: GO:1905517 ! macrophage migration

[Term]
id: GO:1904125
name: convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any convergent extension that is involved in rhombomere morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060029 ! convergent extension involved in organogenesis
relationship: part_of GO:0021593 ! rhombomere morphogenesis

[Term]
id: GO:1904126
name: convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any convergent extension that is involved in notochord morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060029 ! convergent extension involved in organogenesis
relationship: part_of GO:0048570 ! notochord morphogenesis

[Term]
id: GO:1904127
name: regulation of convergent extension involved in somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
relationship: regulates GO:0090246 ! convergent extension involved in somitogenesis

[Term]
id: GO:1904128
name: negative regulation of convergent extension involved in somitogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie]
is_a: GO:1901233 ! negative regulation of convergent extension involved in axis elongation
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis
relationship: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis

[Term]
id: GO:1904129
name: positive regulation of convergent extension involved in somitogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:1901234 ! positive regulation of convergent extension involved in axis elongation
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis
relationship: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis

[Term]
id: GO:1904130
name: regulation of convergent extension involved in neural plate elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
relationship: regulates GO:0022007 ! convergent extension involved in neural plate elongation

[Term]
id: GO:1904131
name: negative regulation of convergent extension involved in neural plate elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie]
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation
relationship: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation

[Term]
id: GO:1904132
name: positive regulation of convergent extension involved in neural plate elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation
relationship: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation

[Term]
id: GO:1904133
name: regulation of convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
relationship: regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis

[Term]
id: GO:1904134
name: negative regulation of convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis
relationship: negatively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis

[Term]
id: GO:1904135
name: positive regulation of convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis
relationship: positively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis

[Term]
id: GO:1904136
name: regulation of convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
relationship: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis

[Term]
id: GO:1904137
name: negative regulation of convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis
relationship: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis

[Term]
id: GO:1904138
name: positive regulation of convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis
relationship: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis

[Term]
id: GO:1904139
name: regulation of microglial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:1903975 ! regulation of glial cell migration
is_a: GO:1905521 ! regulation of macrophage migration
relationship: regulates GO:1904124 ! microglial cell migration

[Term]
id: GO:1904140
name: negative regulation of microglial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell migration" NARROW [GOC:TermGenie]
is_a: GO:1903976 ! negative regulation of glial cell migration
is_a: GO:1904139 ! regulation of microglial cell migration
is_a: GO:1905522 ! negative regulation of macrophage migration
relationship: negatively_regulates GO:1904124 ! microglial cell migration

[Term]
id: GO:1904141
name: positive regulation of microglial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell migration" EXACT [GOC:TermGenie]
is_a: GO:1903977 ! positive regulation of glial cell migration
is_a: GO:1904139 ! regulation of microglial cell migration
is_a: GO:1905523 ! positive regulation of macrophage migration
relationship: positively_regulates GO:1904124 ! microglial cell migration

[Term]
id: GO:1904142
name: negative regulation of carotenoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505]
synonym: "down regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of carotenoid anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid formation" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0016117 ! carotenoid biosynthetic process

[Term]
id: GO:1904143
name: positive regulation of carotenoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505]
synonym: "activation of carotenoid anabolism" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid formation" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
relationship: positively_regulates GO:0016117 ! carotenoid biosynthetic process

[Term]
id: GO:1904144
name: phosphatidylinositol phosphate phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12525165]
comment: An example of this is ACPP in human (P15309) in PMID:12525165 (inferred from physical interaction).
synonym: "prostatic acid phosphatase complex" NARROW []
is_a: GO:1903293 ! phosphatase complex

[Term]
id: GO:1904145
name: negative regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1900194 ! negative regulation of oocyte maturation
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
relationship: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation

[Term]
id: GO:1904146
name: positive regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
relationship: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation

[Term]
id: GO:1904147
name: response to nonylphenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1904148
name: cellular response to nonylphenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904147 ! response to nonylphenol

[Term]
id: GO:1904149
name: regulation of microglial cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: regulates GO:0090634 ! microglial cell mediated cytotoxicity

[Term]
id: GO:1904150
name: negative regulation of microglial cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie]
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity
relationship: negatively_regulates GO:0090634 ! microglial cell mediated cytotoxicity

[Term]
id: GO:1904151
name: positive regulation of microglial cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity
relationship: positively_regulates GO:0090634 ! microglial cell mediated cytotoxicity

[Term]
id: GO:1904152
name: regulation of retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]
synonym: "regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
relationship: regulates GO:0030970 ! retrograde protein transport, ER to cytosol

[Term]
id: GO:1904153
name: negative regulation of retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]
synonym: "down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0070862 ! negative regulation of protein exit from endoplasmic reticulum
is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol
relationship: negatively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol

[Term]
id: GO:1904154
name: positive regulation of retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]
synonym: "activation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "activation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "activation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "positive regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "up regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "up regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "up regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "up-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "upregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0070863 ! positive regulation of protein exit from endoplasmic reticulum
is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol
relationship: positively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol

[Term]
id: GO:1904155
name: DN2 thymocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]
is_a: GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:1904156
name: DN3 thymocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]
is_a: GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:1904157
name: DN4 thymocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN4 thymocyte. A DN4 thymocyte is a CD4-,CD8- thymocyte that is also CD44-,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]
is_a: GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:1904158
name: axonemal central apparatus assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136]
synonym: "axonemal central apparatus formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0035082 ! axoneme assembly

[Term]
id: GO:1904159
name: megasporocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a megasporocyte." [GO_REF:0000086, GOC:tair_curators, GOC:TermGenie]
comment: The process aimed at the progression of a megasporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A megasporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) megaspores; also called megaspore mother cell.
synonym: "megaspore mother cell differentiation" EXACT [GOC:tair_curators]
is_a: GO:0048533 ! sporocyte differentiation

[Term]
id: GO:1904160
name: protein localization to chloroplast starch grain
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a chloroplast starch grain." [GO_REF:0000087, GOC:TermGenie, PMID:25710501]
synonym: "protein localisation in chloroplast starch grain" EXACT [GOC:TermGenie]
synonym: "protein localisation to chloroplast starch grain" EXACT [GOC:TermGenie]
synonym: "protein localization in chloroplast starch grain" EXACT [GOC:TermGenie]
is_a: GO:0072598 ! protein localization to chloroplast

[Term]
id: GO:1904161
name: DNA synthesis involved in UV-damage excision repair
namespace: biological_process
def: "Any DNA synthesis that is involved in UV-damage excision repair." [GO_REF:0000060, GOC:TermGenie, PMID:10704216]
synonym: "DNA synthesis during UV-damage excision repair" RELATED [GOC:TermGenie]
synonym: "DNA synthesis during UV-damaged DNA endonuclease-dependent excision repair" RELATED [GOC:TermGenie]
synonym: "DNA synthesis during UVDE-dependent excision repair" RELATED [GOC:TermGenie]
synonym: "DNA synthesis during UVER" RELATED [GOC:TermGenie]
synonym: "DNA synthesis involved in AER" RELATED [GOC:mah, PMID:10704216]
synonym: "DNA synthesis involved in alternative excision repair" RELATED [GOC:mah, PMID:10704216]
synonym: "DNA synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in UVER" EXACT [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UV-damage excision repair" NARROW [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" NARROW [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UVDE-dependent excision repair" NARROW [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UVER" NARROW [GOC:TermGenie]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
relationship: part_of GO:0070914 ! UV-damage excision repair

[Term]
id: GO:1904162
name: obsolete 5'-3' exodeoxyribonuclease activity involved in UV-damage excision repair
namespace: molecular_function
def: "OBSOLETE. Any 5'-3' exodeoxyribonuclease activity that is involved in UV-damage excision repair." [GO_REF:0000061, GOC:TermGenie, PMID:10704216]
comment: The reason for obsoletion is that this term represents a biological process within a molecular function.
synonym: "5'-3' exodeoxyribonuclease activity involved in AER" RELATED [GOC:mah]
synonym: "5'-3' exodeoxyribonuclease activity involved in alternative excision repair" RELATED [GOC:mah]
synonym: "5'-3' exodeoxyribonuclease activity involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "5'-3' exodeoxyribonuclease activity involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "5'-3' exodeoxyribonuclease activity involved in UVER" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0070914

[Term]
id: GO:1904163
name: obsolete regulation of triglyceride homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904164
name: obsolete negative regulation of triglyceride homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "down regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of triacylglycerol homeostasis" NARROW [GOC:TermGenie]
synonym: "inhibition of triglyceride homeostasis" NARROW [GOC:TermGenie]
synonym: "negative regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904165
name: obsolete positive regulation of triglyceride homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of triacylglycerol homeostasis" NARROW [GOC:TermGenie]
synonym: "activation of triglyceride homeostasis" NARROW [GOC:TermGenie]
synonym: "positive regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "up regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "up regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904166
name: obsolete negative regulation of cholesterol homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of cholesterol homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholesterol homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of cholesterol homeostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of cholesterol homeostasis" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904170
name: regulation of bleb assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: regulates GO:0032060 ! bleb assembly

[Term]
id: GO:1904171
name: negative regulation of bleb assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1904170 ! regulation of bleb assembly
relationship: negatively_regulates GO:0032060 ! bleb assembly

[Term]
id: GO:1904172
name: positive regulation of bleb assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "activation of bleb assembly" NARROW [GOC:TermGenie]
synonym: "activation of cell blebbing" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1904170 ! regulation of bleb assembly
relationship: positively_regulates GO:0032060 ! bleb assembly

[Term]
id: GO:1904173
name: obsolete regulation of histone demethylase activity (H3-K4 specific)
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006338
consider: GO:0031507
consider: GO:0045815
consider: GO:0140673

[Term]
id: GO:1904174
name: obsolete negative regulation of histone demethylase activity (H3-K4 specific)
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "downregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "inhibition of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0031507

[Term]
id: GO:1904175
name: obsolete positive regulation of histone demethylase activity (H3-K4 specific)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie]
synonym: "up regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "upregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0006338
consider: GO:0045815
consider: GO:0140673

[Term]
id: GO:1904176
name: carbon phosphorus lyase complex
namespace: cellular_component
def: "A protein complex which is capable of carbon phosphorus lyase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17993513, PMID:21705661, PMID:22089136, PMID:23830682]
comment: An example of this is PhnJ in E. coli (P16688) in PMID:22089136 (inferred from direct assay).
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1904177
name: regulation of adipose tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0060612 ! adipose tissue development

[Term]
id: GO:1904178
name: negative regulation of adipose tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
relationship: negatively_regulates GO:0060612 ! adipose tissue development

[Term]
id: GO:1904179
name: positive regulation of adipose tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "activation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
relationship: positively_regulates GO:0060612 ! adipose tissue development

[Term]
id: GO:1904180
name: negative regulation of membrane depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "down regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane depolarization" NARROW [GOC:TermGenie]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0051899 ! membrane depolarization

[Term]
id: GO:1904181
name: positive regulation of membrane depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "activation of membrane depolarization" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization" EXACT [GOC:TermGenie]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0051899 ! membrane depolarization

[Term]
id: GO:1904182
name: regulation of pyruvate dehydrogenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]
subset: gocheck_obsoletion_candidate
synonym: "regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1904183
name: obsolete negative regulation of pyruvate dehydrogenase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904184
name: obsolete positive regulation of pyruvate dehydrogenase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904185
name: equatorial microtubule organizing center assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center." [GO_REF:0000079, GOC:TermGenie, PMID:15004232]
synonym: "EMTOC assembly" EXACT [GOC:TermGenie]
synonym: "EMTOC formation" EXACT [GOC:TermGenie]
synonym: "equatorial microtubule organising centre assembly" EXACT [GOC:TermGenie]
synonym: "equatorial microtubule organising centre formation" EXACT [GOC:TermGenie]
synonym: "equatorial microtubule organizing center formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:1904186
name: post-anaphase microtubule array organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly ofa post-anaphase microtubule array." [GOC:TermGenie, PMID:15004232]
synonym: "PAA organization" EXACT [GOC:TermGenie]
synonym: "post-anaphase array organization" EXACT [GOC:TermGenie]
synonym: "post-anaphase microtubule array organisation" EXACT []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:1904187
name: regulation of transformation of host cell by virus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142]
synonym: "regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
relationship: regulates GO:0019087 ! symbiont-mediated transformation of host cell

[Term]
id: GO:1904188
name: negative regulation of transformation of host cell by virus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142]
synonym: "down regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "down regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "down regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "downregulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "downregulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "inhibition of transformation of host cell by virus" NARROW [GOC:TermGenie]
synonym: "inhibition of viral transformation" NARROW [GOC:TermGenie]
synonym: "inhibition of viral transformation of host cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904187 ! regulation of transformation of host cell by virus
relationship: negatively_regulates GO:0019087 ! symbiont-mediated transformation of host cell

[Term]
id: GO:1904189
name: positive regulation of transformation of host cell by virus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142]
synonym: "activation of transformation of host cell by virus" NARROW [GOC:TermGenie]
synonym: "activation of viral transformation" NARROW [GOC:TermGenie]
synonym: "activation of viral transformation of host cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "up regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "up regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "upregulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "upregulation of viral transformation of host cell" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904187 ! regulation of transformation of host cell by virus
relationship: positively_regulates GO:0019087 ! symbiont-mediated transformation of host cell

[Term]
id: GO:1904191
name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division
namespace: biological_process
def: "OBSOLETE. Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division." [GO_REF:0000060, GOC:TermGenie, PMID:15791259]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie]
synonym: "positive regulation of CDK activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclin-dependent protein kinase activity involved in meiosis" BROAD [GOC:TermGenie]
synonym: "stimulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904192
name: regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: regulates GO:1902488 ! cholangiocyte apoptotic process

[Term]
id: GO:1904193
name: negative regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process
relationship: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process

[Term]
id: GO:1904194
name: positive regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process
relationship: positively_regulates GO:1902488 ! cholangiocyte apoptotic process

[Term]
id: GO:1904195
name: regulation of granulosa cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:1990739 ! granulosa cell proliferation

[Term]
id: GO:1904196
name: negative regulation of granulosa cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759]
synonym: "down regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of granulosa cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904195 ! regulation of granulosa cell proliferation
relationship: negatively_regulates GO:1990739 ! granulosa cell proliferation

[Term]
id: GO:1904197
name: positive regulation of granulosa cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759]
synonym: "activation of granulosa cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904195 ! regulation of granulosa cell proliferation
relationship: positively_regulates GO:1990739 ! granulosa cell proliferation

[Term]
id: GO:1904198
name: negative regulation of regulation of vascular associated smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "down regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT []
is_a: GO:1904180 ! negative regulation of membrane depolarization
relationship: negatively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization

[Term]
id: GO:1904199
name: positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "activation of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT []
synonym: "up regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
is_a: GO:1904181 ! positive regulation of membrane depolarization
relationship: positively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization

[Term]
id: GO:1904200
name: iodide transmembrane transport
namespace: biological_process
def: "The process in which iodide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20392814]
is_a: GO:0015705 ! iodide transport
is_a: GO:0098656 ! monoatomic anion transmembrane transport
is_a: GO:0098661 ! inorganic anion transmembrane transport

[Term]
id: GO:1904201
name: regulation of iodide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
is_a: GO:0044070 ! regulation of monoatomic anion transport
relationship: regulates GO:0015705 ! iodide transport

[Term]
id: GO:1904202
name: negative regulation of iodide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "down regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of iodide transport" NARROW [GOC:TermGenie]
is_a: GO:1903792 ! negative regulation of monoatomic anion transport
is_a: GO:1904201 ! regulation of iodide transport
relationship: negatively_regulates GO:0015705 ! iodide transport

[Term]
id: GO:1904203
name: positive regulation of iodide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "activation of iodide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of iodide transport" EXACT [GOC:TermGenie]
is_a: GO:1903793 ! positive regulation of monoatomic anion transport
is_a: GO:1904201 ! regulation of iodide transport
relationship: positively_regulates GO:0015705 ! iodide transport

[Term]
id: GO:1904204
name: regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
is_a: GO:0014733 ! regulation of skeletal muscle adaptation
is_a: GO:0014743 ! regulation of muscle hypertrophy
relationship: regulates GO:0014734 ! skeletal muscle hypertrophy

[Term]
id: GO:1904205
name: negative regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
relationship: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy

[Term]
id: GO:1904206
name: positive regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy

[Term]
id: GO:1904210
name: VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a VCP-NPL4-UFD1 AAA ATPase complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]
synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904211
name: membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22795130]
synonym: "intramembrane cleavage of ERAD substrate" BROAD [PMID:22795130]
synonym: "intramembrane proteolysis involved in ERAD" EXACT [PMID:22795130]
synonym: "membrane protein proteolysis involved in protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "membrane protein proteolysis involved in protein retrotranslocation, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "membrane protein proteolysis involved in retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0033619 ! membrane protein proteolysis
is_a: GO:0051603 ! proteolysis involved in protein catabolic process
relationship: part_of GO:0030970 ! retrograde protein transport, ER to cytosol

[Term]
id: GO:1904212
name: regulation of iodide transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:1903959 ! regulation of monoatomic anion transmembrane transport
is_a: GO:1904201 ! regulation of iodide transport
relationship: regulates GO:1904200 ! iodide transmembrane transport

[Term]
id: GO:1904213
name: negative regulation of iodide transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "down regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of iodide transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904202 ! negative regulation of iodide transport
is_a: GO:1904212 ! regulation of iodide transmembrane transport
relationship: negatively_regulates GO:1904200 ! iodide transmembrane transport

[Term]
id: GO:1904214
name: positive regulation of iodide transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "activation of iodide transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904203 ! positive regulation of iodide transport
is_a: GO:1904212 ! regulation of iodide transmembrane transport
relationship: positively_regulates GO:1904200 ! iodide transmembrane transport

[Term]
id: GO:1904215
name: regulation of protein import into chloroplast stroma
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327]
synonym: "regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0051223 ! regulation of protein transport
relationship: regulates GO:0045037 ! protein import into chloroplast stroma

[Term]
id: GO:1904216
name: positive regulation of protein import into chloroplast stroma
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327]
synonym: "activation of chloroplast stroma protein import" NARROW [GOC:TermGenie]
synonym: "activation of protein import into chloroplast stroma" NARROW [GOC:TermGenie]
synonym: "activation of protein transport into chloroplast stroma" NARROW [GOC:TermGenie]
synonym: "positive regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "up regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up-regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "upregulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "upregulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "upregulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1904215 ! regulation of protein import into chloroplast stroma
relationship: positively_regulates GO:0045037 ! protein import into chloroplast stroma

[Term]
id: GO:1904217
name: regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate
subset: gocheck_obsoletion_candidate
synonym: "regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine exchange enzyme" BROAD [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1904218
name: obsolete negative regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine synthase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PS synthase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PS synthase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904219
name: obsolete positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of PS synthase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PS synthase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904220
name: regulation of serine C-palmitoyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
subset: gocheck_obsoletion_candidate
synonym: "regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine palmitoyltransferase" BROAD [GOC:TermGenie]
synonym: "regulation of SPT" RELATED [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1904221
name: negative regulation of serine C-palmitoyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
subset: gocheck_obsoletion_candidate
synonym: "down regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "down regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of SPT" RELATED [GOC:TermGenie]
synonym: "down-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "down-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of SPT" RELATED [GOC:TermGenie]
synonym: "downregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "downregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of SPT" RELATED [GOC:TermGenie]
synonym: "inhibition of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "inhibition of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of SPT" RELATED [GOC:TermGenie]
synonym: "negative regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "negative regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of SPT" RELATED [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity

[Term]
id: GO:1904222
name: positive regulation of serine C-palmitoyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
subset: gocheck_obsoletion_candidate
synonym: "activation of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "activation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie]
synonym: "activation of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of SPT" RELATED [GOC:TermGenie]
synonym: "positive regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "positive regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of SPT" RELATED [GOC:TermGenie]
synonym: "up regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "up regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of SPT" RELATED [GOC:TermGenie]
synonym: "up-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "up-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of SPT" RELATED [GOC:TermGenie]
synonym: "upregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "upregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of SPT" RELATED [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity

[Term]
id: GO:1904223
name: regulation of glucuronosyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]
comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species
subset: gocheck_obsoletion_candidate
synonym: "regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1904224
name: obsolete negative regulation of glucuronosyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "down regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "down regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "down-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GT activity" EXACT [GOC:TermGenie]
synonym: "downregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "downregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "inhibition of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPGA transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "negative regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904225
name: obsolete positive regulation of glucuronosyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of GT activity" NARROW [GOC:TermGenie]
synonym: "activation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "activation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPGA transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "positive regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "up regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "up regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "up-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GT activity" EXACT [GOC:TermGenie]
synonym: "upregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "upregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904226
name: regulation of glycogen synthase activity, transferring glucose-1-phosphate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]
subset: gocheck_obsoletion_candidate
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1904227
name: negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "downregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "inhibition of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904226 ! regulation of glycogen synthase activity, transferring glucose-1-phosphate

[Term]
id: GO:1904228
name: obsolete positive regulation of glycogen synthase activity, transferring glucose-1-phosphate
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie]
synonym: "up regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "upregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904229
name: regulation of succinate dehydrogenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
subset: gocheck_obsoletion_candidate
synonym: "regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinic dehydrogenase activity" BROAD [GOC:TermGenie]
synonym: "regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1904230
name: obsolete negative regulation of succinate dehydrogenase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of fumarate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of fumarate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of fumaric hydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinodehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinyl dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904231
name: positive regulation of succinate dehydrogenase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
subset: gocheck_obsoletion_candidate
synonym: "activation of fumarate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of fumarate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of fumaric hydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinodehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinyl dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1904229 ! regulation of succinate dehydrogenase activity

[Term]
id: GO:1904232
name: regulation of aconitate hydratase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
subset: gocheck_obsoletion_candidate
synonym: "regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "regulation of citrate hydro-lyase activity" BROAD [GOC:TermGenie]
synonym: "regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:1904233
name: negative regulation of aconitate hydratase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of aconitase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of aconitate hydratase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cis-aconitase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
is_a: GO:0051350 ! negative regulation of lyase activity
is_a: GO:1904232 ! regulation of aconitate hydratase activity

[Term]
id: GO:1904234
name: positive regulation of aconitate hydratase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
subset: gocheck_obsoletion_candidate
synonym: "activation of aconitase activity" NARROW [GOC:TermGenie]
synonym: "activation of aconitate hydratase activity" NARROW [GOC:TermGenie]
synonym: "activation of cis-aconitase activity" NARROW [GOC:TermGenie]
synonym: "activation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie]
synonym: "activation of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
is_a: GO:0051349 ! positive regulation of lyase activity
is_a: GO:1904232 ! regulation of aconitate hydratase activity

[Term]
id: GO:1904235
name: regulation of substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989]
synonym: "regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate

[Term]
id: GO:1904236
name: negative regulation of substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989]
synonym: "down regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "down regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "downregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "downregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "inhibition of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "inhibition of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "negative regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate
relationship: negatively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate

[Term]
id: GO:1904237
name: positive regulation of substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989]
synonym: "activation of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "activation of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "positive regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "upregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "upregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate
relationship: positively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate

[Term]
id: GO:1904238
name: pericyte cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:1904239
name: regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly

[Term]
id: GO:1904240
name: negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]
synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
relationship: negatively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly

[Term]
id: GO:1904241
name: positive regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "activation of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
relationship: positively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly

[Term]
id: GO:1904242
name: regulation of pancreatic trypsinogen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515]
synonym: "regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:1990747 ! pancreatic trypsinogen secretion

[Term]
id: GO:1904243
name: negative regulation of pancreatic trypsinogen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515]
synonym: "down regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "down regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of pancreatic trypsinogen release" NARROW [GOC:TermGenie]
synonym: "inhibition of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion
relationship: negatively_regulates GO:1990747 ! pancreatic trypsinogen secretion

[Term]
id: GO:1904244
name: positive regulation of pancreatic trypsinogen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515]
synonym: "activation of pancreatic trypsinogen release" NARROW [GOC:TermGenie]
synonym: "activation of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion
relationship: positively_regulates GO:1990747 ! pancreatic trypsinogen secretion

[Term]
id: GO:1904245
name: regulation of polynucleotide adenylyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]
subset: gocheck_obsoletion_candidate
synonym: "regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1904246
name: negative regulation of polynucleotide adenylyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "down regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "down-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "downregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NTP polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly(A) hydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly(A) polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly(A) synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly-A polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylate polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylic polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA adenylating enzyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "inhibition of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "negative regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity

[Term]
id: GO:1904247
name: positive regulation of polynucleotide adenylyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]
subset: gocheck_obsoletion_candidate
synonym: "activation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of NTP polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly(A) hydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly(A) polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly(A) synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly-A polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylate polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylic polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of RNA adenylating enzyme activity" NARROW [GOC:TermGenie]
synonym: "activation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "activation of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "positive regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "up regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "up-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "upregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity

[Term]
id: GO:1904248
name: regulation of age-related resistance
namespace: biological_process
def: "Any process that modulates the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953]
synonym: "regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "regulation of ARR" EXACT [GOC:TermGenie]
synonym: "regulation of developmental resistance" BROAD [GOC:TermGenie]
synonym: "regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "regulation of ontogenic resistance" BROAD [GOC:TermGenie]
synonym: "regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0090644 ! age-related resistance

[Term]
id: GO:1904249
name: negative regulation of age-related resistance
namespace: biological_process
def: "Any process that stops, prevents or reduces the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953]
synonym: "down regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "down regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "down regulation of ARR" EXACT [GOC:TermGenie]
synonym: "down regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "down regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "down regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "down-regulation of ARR" EXACT [GOC:TermGenie]
synonym: "down-regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "downregulation of ARR" EXACT [GOC:TermGenie]
synonym: "downregulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of age-related resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of ARR" NARROW [GOC:TermGenie]
synonym: "inhibition of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of ARR" EXACT [GOC:TermGenie]
synonym: "negative regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904248 ! regulation of age-related resistance
relationship: negatively_regulates GO:0090644 ! age-related resistance

[Term]
id: GO:1904250
name: positive regulation of age-related resistance
namespace: biological_process
def: "Any process that activates or increases the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953]
synonym: "activation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "activation of age-related resistance" NARROW [GOC:TermGenie]
synonym: "activation of ARR" NARROW [GOC:TermGenie]
synonym: "activation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "activation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "activation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of ARR" EXACT [GOC:TermGenie]
synonym: "positive regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "up regulation of ARR" EXACT [GOC:TermGenie]
synonym: "up regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "up-regulation of ARR" EXACT [GOC:TermGenie]
synonym: "up-regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "upregulation of ARR" EXACT [GOC:TermGenie]
synonym: "upregulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of senescence-induced resistance" NARROW [GOC:TermGenie]
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904248 ! regulation of age-related resistance
relationship: positively_regulates GO:0090644 ! age-related resistance

[Term]
id: GO:1904251
name: regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "regulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0008206 ! bile acid metabolic process

[Term]
id: GO:1904252
name: negative regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "down regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of bile acid metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of bile acid metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
relationship: negatively_regulates GO:0008206 ! bile acid metabolic process

[Term]
id: GO:1904253
name: positive regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "activation of bile acid metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of bile acid metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
relationship: positively_regulates GO:0008206 ! bile acid metabolic process

[Term]
id: GO:1904254
name: regulation of iron ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
subset: gocheck_obsoletion_candidate
synonym: "regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of iron channel activity" EXACT []
synonym: "regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0034759 ! regulation of iron ion transmembrane transport

[Term]
id: GO:1904255
name: obsolete negative regulation of iron ion transmembrane transporter activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of iron cation channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iron channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iron-specific channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron channel activity" EXACT []
synonym: "negative regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904256
name: obsolete positive regulation of iron ion transmembrane transporter activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of iron cation channel activity" NARROW [GOC:TermGenie]
synonym: "activation of iron channel activity" NARROW [GOC:TermGenie]
synonym: "activation of iron-specific channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron channel activity" EXACT []
synonym: "positive regulation of iron transmembrane transporter activity" EXACT []
synonym: "positive regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-specific channel activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904257
name: zinc ion import into Golgi lumen
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]
synonym: "cytosol to Golgi apparatus zinc transport" EXACT []
synonym: "zinc II ion import across Golgi membrane" EXACT []
synonym: "zinc ion import across Golgi membrane" EXACT []
synonym: "zinc ion import into Golgi apparatus" EXACT []
synonym: "zinc ion import into Golgi membrane" RELATED []
synonym: "zinc(2+) import across Golgi membrane" EXACT []
is_a: GO:0062111 ! zinc ion import into organelle
is_a: GO:0140820 ! cytosol to Golgi apparatus transport

[Term]
id: GO:1904258
name: nuclear dicing body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear dicing body." [GO_REF:0000079, GOC:TermGenie, PMID:25902521]
synonym: "D body assembly" EXACT [GOC:TermGenie]
synonym: "D body formation" EXACT [GOC:TermGenie]
synonym: "nuclear dicing body formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:1904259
name: regulation of basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0110011 ! regulation of basement membrane organization
is_a: GO:1901201 ! regulation of extracellular matrix assembly
relationship: regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis

[Term]
id: GO:1904260
name: negative regulation of basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]
synonym: "down regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901202 ! negative regulation of extracellular matrix assembly
is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis
relationship: negatively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis

[Term]
id: GO:1904261
name: positive regulation of basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]
synonym: "activation of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901203 ! positive regulation of extracellular matrix assembly
is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis
relationship: positively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis

[Term]
id: GO:1904262
name: negative regulation of TORC1 signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
synonym: "down regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of TORC1 signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of TORC1 signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032007 ! negative regulation of TOR signaling
is_a: GO:1903432 ! regulation of TORC1 signaling
relationship: negatively_regulates GO:0038202 ! TORC1 signaling

[Term]
id: GO:1904263
name: positive regulation of TORC1 signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
synonym: "activation of TORC1 signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of TORC1 signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC1 signaling" EXACT [GOC:TermGenie]
is_a: GO:0032008 ! positive regulation of TOR signaling
is_a: GO:1903432 ! regulation of TORC1 signaling
relationship: positively_regulates GO:0038202 ! TORC1 signaling

[Term]
id: GO:1904266
name: regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1900147 ! regulation of Schwann cell migration
relationship: regulates GO:1990751 ! Schwann cell chemotaxis

[Term]
id: GO:1904267
name: negative regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
synonym: "down regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell chemotaxis" NARROW [GOC:TermGenie]
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1900148 ! negative regulation of Schwann cell migration
is_a: GO:1904266 ! regulation of Schwann cell chemotaxis
relationship: negatively_regulates GO:1990751 ! Schwann cell chemotaxis

[Term]
id: GO:1904268
name: positive regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
synonym: "activation of Schwann cell chemotaxis" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1900149 ! positive regulation of Schwann cell migration
is_a: GO:1904266 ! regulation of Schwann cell chemotaxis
relationship: positively_regulates GO:1990751 ! Schwann cell chemotaxis

[Term]
id: GO:1904269
name: cell leading edge cell cortex
namespace: cellular_component
def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030]
synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie]
synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie]
synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie]
synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie]
synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie]
synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie]
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:1904270
name: pyroptosome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex." [GO_REF:0000079, GOC:TermGenie, PMID:17964261]
synonym: "ASC pyroptosome assembly" EXACT [GOC:TermGenie]
synonym: "ASC pyroptosome formation" EXACT [GOC:TermGenie]
synonym: "pyroptosome complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904271
name: L-proline import across plasma membrane
namespace: biological_process
alt_id: GO:1903809
def: "The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]
synonym: "L-proline import into cell" EXACT []
is_a: GO:1904555 ! L-proline transmembrane transport
is_a: GO:1905647 ! proline import across plasma membrane

[Term]
id: GO:1904272
name: L-tryptophan import across plasma membrane
namespace: biological_process
def: "The directed movement of L-tryptophan from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1904556 ! L-tryptophan transmembrane transport

[Term]
id: GO:1904273
name: L-alanine import across plasma membrane
namespace: biological_process
def: "The directed import of L-alanine from the extracellular region across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1904557 ! L-alanine transmembrane transport

[Term]
id: GO:1904274
name: tricellular tight junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a tricellular tight junction." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962]
synonym: "tricellular tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:0120192 ! tight junction assembly

[Term]
id: GO:1904275
name: tricellular tight junction disassembly
namespace: biological_process
def: "The disaggregation of a tricellular tight junction into its constituent components." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962]
is_a: GO:1905071 ! tight junction disassembly

[Term]
id: GO:1904276
name: regulation of wax biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420]
synonym: "regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "regulation of wax synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0010025 ! wax biosynthetic process

[Term]
id: GO:1904277
name: negative regulation of wax biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420]
synonym: "down regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "down regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of wax formation" EXACT [GOC:TermGenie]
synonym: "downregulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of wax anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of wax biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of wax biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of wax formation" NARROW [GOC:TermGenie]
synonym: "inhibition of wax synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of wax synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1904276 ! regulation of wax biosynthetic process
relationship: negatively_regulates GO:0010025 ! wax biosynthetic process

[Term]
id: GO:1904278
name: positive regulation of wax biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420]
synonym: "activation of wax anabolism" NARROW [GOC:TermGenie]
synonym: "activation of wax biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of wax biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of wax formation" NARROW [GOC:TermGenie]
synonym: "activation of wax synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "up regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of wax formation" EXACT [GOC:TermGenie]
synonym: "upregulation of wax synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1904276 ! regulation of wax biosynthetic process
relationship: positively_regulates GO:0010025 ! wax biosynthetic process

[Term]
id: GO:1904279
name: regulation of transcription by RNA polymerase V
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328]
synonym: "regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase V promoter" EXACT []
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0001060 ! transcription by RNA polymerase V

[Term]
id: GO:1904280
name: negative regulation of transcription by RNA polymerase V
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328]
synonym: "down regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA pol V promoter" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase V promoter" EXACT []
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
is_a: GO:1904279 ! regulation of transcription by RNA polymerase V
relationship: negatively_regulates GO:0001060 ! transcription by RNA polymerase V

[Term]
id: GO:1904281
name: positive regulation of transcription by RNA polymerase V
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328]
synonym: "activation of transcription from RNA pol V promoter" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase V promoter" EXACT []
synonym: "up regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:1904279 ! regulation of transcription by RNA polymerase V
relationship: positively_regulates GO:0001060 ! transcription by RNA polymerase V

[Term]
id: GO:1904282
name: regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]
synonym: "regulation of antigen presentation, endogenous peptide antigen" BROAD [GOC:TermGenie]
synonym: "regulation of antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [GOC:TermGenie]
synonym: "regulation of antigen processing, endogenous antigen via MHC class I" BROAD [GOC:TermGenie]
synonym: "regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
relationship: regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:1904283
name: negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]
synonym: "down regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "down regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "down-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "down-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "downregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "downregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "inhibition of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie]
synonym: "inhibition of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie]
synonym: "negative regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
is_a: GO:0002590 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
relationship: negatively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:1904284
name: positive regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]
synonym: "activation of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie]
synonym: "activation of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie]
synonym: "positive regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "up regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "up regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "up-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "up-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "upregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "upregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
is_a: GO:0002591 ! positive regulation of antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
relationship: positively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:1904285
name: regulation of protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689]
subset: gocheck_obsoletion_candidate
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage

[Term]
id: GO:1904286
name: negative regulation of protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "inhibition of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage
relationship: negatively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage

[Term]
id: GO:1904287
name: positive regulation of protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie]
synonym: "stimulation of protein-pyridoxal-5-phosphate linkage" EXACT []
synonym: "up regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage
relationship: positively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage

[Term]
id: GO:1904288
name: BAT3 complex binding
namespace: molecular_function
def: "Binding to a BAT3 complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23246001]
synonym: "Bag6 complex binding" EXACT [GOC:TermGenie]
synonym: "BAG6-UBL4A-TRC35 complex binding" EXACT [GOC:TermGenie]
synonym: "BAT3-TRC35-UBL4A complex binding" RELATED [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1904289
name: regulation of mitotic DNA damage checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:2000001 ! regulation of DNA damage checkpoint
relationship: regulates GO:0044773 ! mitotic DNA damage checkpoint signaling

[Term]
id: GO:1904290
name: negative regulation of mitotic DNA damage checkpoint
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]
synonym: "down regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint
is_a: GO:2000002 ! negative regulation of DNA damage checkpoint
relationship: negatively_regulates GO:0044773 ! mitotic DNA damage checkpoint signaling

[Term]
id: GO:1904291
name: positive regulation of mitotic DNA damage checkpoint
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]
synonym: "activation of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint
is_a: GO:2000003 ! positive regulation of DNA damage checkpoint
relationship: positively_regulates GO:0044773 ! mitotic DNA damage checkpoint signaling

[Term]
id: GO:1904292
name: regulation of ERAD pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress
relationship: regulates GO:0036503 ! ERAD pathway

[Term]
id: GO:1904293
name: negative regulation of ERAD pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22590560]
synonym: "down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process
is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress
is_a: GO:1904292 ! regulation of ERAD pathway
relationship: negatively_regulates GO:0036503 ! ERAD pathway

[Term]
id: GO:1904294
name: positive regulation of ERAD pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of ERAD pathway" EXACT [GOC:TermGenie]
is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process
is_a: GO:1904292 ! regulation of ERAD pathway
is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress
relationship: positively_regulates GO:0036503 ! ERAD pathway

[Term]
id: GO:1904295
name: regulation of osmolarity-sensing cation channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313]
subset: gocheck_obsoletion_candidate
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1904296
name: obsolete negative regulation of osmolarity-sensing cation channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904297
name: obsolete positive regulation of osmolarity-sensing cation channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904298
name: regulation of transcytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0045056 ! transcytosis

[Term]
id: GO:1904299
name: negative regulation of transcytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076]
synonym: "down regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcytosis" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904298 ! regulation of transcytosis
relationship: negatively_regulates GO:0045056 ! transcytosis

[Term]
id: GO:1904300
name: positive regulation of transcytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076]
synonym: "activation of transcytosis" NARROW [GOC:TermGenie]
synonym: "up regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of transcytosis" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904298 ! regulation of transcytosis
relationship: positively_regulates GO:0045056 ! transcytosis

[Term]
id: GO:1904301
name: regulation of maternal process involved in parturition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0060137 ! maternal process involved in parturition

[Term]
id: GO:1904302
name: negative regulation of maternal process involved in parturition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751]
synonym: "down regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "down-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "downregulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "inhibition of maternal process involved in parturition" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904301 ! regulation of maternal process involved in parturition
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0060137 ! maternal process involved in parturition

[Term]
id: GO:1904303
name: positive regulation of maternal process involved in parturition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751]
synonym: "activation of maternal process involved in parturition" NARROW [GOC:TermGenie]
synonym: "up regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "up-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "upregulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904301 ! regulation of maternal process involved in parturition
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0060137 ! maternal process involved in parturition

[Term]
id: GO:1904304
name: regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
is_a: GO:0006940 ! regulation of smooth muscle contraction
relationship: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:1904305
name: negative regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
synonym: "down regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
relationship: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:1904306
name: positive regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
synonym: "activation of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
relationship: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:1904307
name: response to desipramine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904308
name: cellular response to desipramine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904307 ! response to desipramine

[Term]
id: GO:1904309
name: response to cordycepin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460]
synonym: "response to 3'-deoxyadenosine" EXACT [GOC:sl]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904310
name: cellular response to cordycepin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460]
synonym: "cellular response to 3'-deoxyadenosine" EXACT [GOC:sl]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904309 ! response to cordycepin

[Term]
id: GO:1904311
name: response to gold(3+)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1904312
name: cellular response to gold(3+)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904311 ! response to gold(3+)

[Term]
id: GO:1904313
name: response to methamphetamine hydrochloride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933]
synonym: "response to methamphetamine HCL" EXACT []
is_a: GO:0014075 ! response to amine

[Term]
id: GO:1904314
name: cellular response to methamphetamine hydrochloride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933]
synonym: "cellular response to methamphetamine HCL" EXACT []
is_a: GO:0071418 ! cellular response to amine stimulus
is_a: GO:1904313 ! response to methamphetamine hydrochloride

[Term]
id: GO:1904315
name: transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]
subset: goslim_synapse
synonym: "ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential" NARROW [GOC:TermGenie]
synonym: "ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" NARROW [GOC:TermGenie]
synonym: "transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" BROAD []
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

[Term]
id: GO:1904316
name: response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918]
synonym: "response to PAF" EXACT []
synonym: "response to platelet-activating factor" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:0045472 ! response to ether
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904317
name: cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918]
synonym: "cellular response to PAF" EXACT []
synonym: "cellular response to platelet-activating factor" EXACT []
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904316 ! response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine

[Term]
id: GO:1904318
name: regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044062 ! regulation of excretion
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:0060083 ! smooth muscle contraction involved in micturition

[Term]
id: GO:1904319
name: negative regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "down regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "down regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "down regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "down-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "down-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "downregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "downregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "inhibition of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie]
synonym: "inhibition of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "inhibition of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "negative regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "negative regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition
relationship: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition

[Term]
id: GO:1904320
name: positive regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "activation of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie]
synonym: "activation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "activation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "positive regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "positive regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "up regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "up regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "up regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "up-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "up-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "upregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "upregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition
relationship: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition

[Term]
id: GO:1904321
name: response to forskolin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1904322
name: cellular response to forskolin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904321 ! response to forskolin

[Term]
id: GO:1904323
name: regulation of inhibitory G protein-coupled receptor phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517]
subset: gocheck_obsoletion_candidate
synonym: "regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT []
is_a: GO:0001932 ! regulation of protein phosphorylation
relationship: regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation

[Term]
id: GO:1904324
name: negative regulation of inhibitory G protein-coupled receptor phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "inhibition of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT []
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:1904323 ! regulation of inhibitory G protein-coupled receptor phosphorylation
relationship: negatively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation

[Term]
id: GO:1904325
name: positive regulation of inhibitory G protein-coupled receptor phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517]
subset: gocheck_obsoletion_candidate
synonym: "activation of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT []
synonym: "up regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:1904323 ! regulation of inhibitory G protein-coupled receptor phosphorylation
relationship: positively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation

[Term]
id: GO:1904326
name: negative regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of circadian sleep/wake cycle, wakefulness." [GO_REF:0000058, GOC:TermGenie, PMID:10923657]
synonym: "down regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie]
synonym: "down-regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie]
synonym: "downregulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie]
synonym: "inhibition of circadian sleep/wake cycle, wakefulness" NARROW [GOC:TermGenie]
is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness
is_a: GO:0042754 ! negative regulation of circadian rhythm
is_a: GO:0048521 ! negative regulation of behavior
relationship: negatively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness

[Term]
id: GO:1904327
name: protein localization to cytosolic proteasome complex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]
synonym: "protein localisation in cytosolic proteasome complex" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytosolic proteasome complex" EXACT [GOC:TermGenie]
synonym: "protein localization in cytosolic proteasome complex" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1904328
name: regulation of myofibroblast contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477]
synonym: "regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "regulation of MFB contraction" EXACT [GOC:TermGenie]
is_a: GO:1903115 ! regulation of actin filament-based movement
relationship: regulates GO:1990764 ! myofibroblast contraction

[Term]
id: GO:1904329
name: negative regulation of myofibroblast contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477]
synonym: "down regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "down regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "down regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of MF contraction" NARROW [GOC:TermGenie]
synonym: "inhibition of MFB contraction" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast contraction" NARROW [GOC:TermGenie]
synonym: "negative regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "negative regulation of MFB contraction" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1904328 ! regulation of myofibroblast contraction
relationship: negatively_regulates GO:1990764 ! myofibroblast contraction

[Term]
id: GO:1904330
name: positive regulation of myofibroblast contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477]
synonym: "activation of MF contraction" NARROW [GOC:TermGenie]
synonym: "activation of MFB contraction" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast contraction" NARROW [GOC:TermGenie]
synonym: "positive regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "positive regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "up regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "up regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast contraction" EXACT [GOC:TermGenie]
is_a: GO:1903116 ! positive regulation of actin filament-based movement
is_a: GO:1904328 ! regulation of myofibroblast contraction
relationship: positively_regulates GO:1990764 ! myofibroblast contraction

[Term]
id: GO:1904331
name: regulation of error-prone translesion synthesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]
synonym: "regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "regulation of mutagenic PRR" EXACT [GOC:TermGenie]
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:2000278 ! regulation of DNA biosynthetic process
relationship: regulates GO:0042276 ! error-prone translesion synthesis

[Term]
id: GO:1904332
name: negative regulation of error-prone translesion synthesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]
synonym: "down regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "down-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down-regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "downregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "downregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "downregulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "inhibition of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "inhibition of error-prone translesion synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "inhibition of mutagenic PRR" NARROW [GOC:TermGenie]
synonym: "negative regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "negative regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "negative regulation of mutagenic PRR" EXACT [GOC:TermGenie]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:1904331 ! regulation of error-prone translesion synthesis
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
relationship: negatively_regulates GO:0042276 ! error-prone translesion synthesis

[Term]
id: GO:1904333
name: positive regulation of error-prone translesion synthesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]
synonym: "activation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "activation of error-prone translesion synthesis" NARROW [GOC:TermGenie]
synonym: "activation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "activation of mutagenic PRR" NARROW [GOC:TermGenie]
synonym: "positive regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "positive regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "positive regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "up regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "up-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up-regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "upregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "upregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "upregulation of mutagenic PRR" EXACT [GOC:TermGenie]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:1904331 ! regulation of error-prone translesion synthesis
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
relationship: positively_regulates GO:0042276 ! error-prone translesion synthesis

[Term]
id: GO:1904334
name: heme import across plasma membrane
namespace: biological_process
def: "The directed movement of heme from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:25733668]
synonym: "heme assimilation" BROAD []
is_a: GO:0035351 ! heme transmembrane transport
is_a: GO:0098711 ! iron ion import across plasma membrane
is_a: GO:0140420 ! heme import into cell

[Term]
id: GO:1904335
name: regulation of ductus arteriosus closure
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610]
is_a: GO:1905651 ! regulation of artery morphogenesis
relationship: regulates GO:0097070 ! ductus arteriosus closure

[Term]
id: GO:1904336
name: negative regulation of ductus arteriosus closure
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610]
synonym: "down regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "down-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "downregulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "inhibition of ductus arteriosus closure" NARROW [GOC:TermGenie]
is_a: GO:1904335 ! regulation of ductus arteriosus closure
is_a: GO:1905652 ! negative regulation of artery morphogenesis
relationship: negatively_regulates GO:0097070 ! ductus arteriosus closure

[Term]
id: GO:1904337
name: positive regulation of ductus arteriosus closure
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610]
synonym: "activation of ductus arteriosus closure" NARROW [GOC:TermGenie]
synonym: "up regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "up-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "upregulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
is_a: GO:1904335 ! regulation of ductus arteriosus closure
is_a: GO:1905653 ! positive regulation of artery morphogenesis
relationship: positively_regulates GO:0097070 ! ductus arteriosus closure

[Term]
id: GO:1904338
name: regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0071542 ! dopaminergic neuron differentiation

[Term]
id: GO:1904339
name: negative regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
synonym: "down regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
relationship: negatively_regulates GO:0071542 ! dopaminergic neuron differentiation

[Term]
id: GO:1904340
name: positive regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
synonym: "activation of dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
relationship: positively_regulates GO:0071542 ! dopaminergic neuron differentiation

[Term]
id: GO:1904341
name: regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
relationship: regulates GO:1990765 ! colon smooth muscle contraction

[Term]
id: GO:1904342
name: negative regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904341 ! regulation of colon smooth muscle contraction
relationship: negatively_regulates GO:1990765 ! colon smooth muscle contraction

[Term]
id: GO:1904343
name: positive regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904341 ! regulation of colon smooth muscle contraction
relationship: positively_regulates GO:1990765 ! colon smooth muscle contraction

[Term]
id: GO:1904344
name: regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903522 ! regulation of blood circulation
relationship: regulates GO:1990768 ! gastric mucosal blood circulation

[Term]
id: GO:1904345
name: negative regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "down regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "inhibition of gastric mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "inhibition of stomach mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "negative regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903523 ! negative regulation of blood circulation
is_a: GO:1904344 ! regulation of gastric mucosal blood circulation
relationship: negatively_regulates GO:1990768 ! gastric mucosal blood circulation

[Term]
id: GO:1904346
name: positive regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "activation of gastric mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "activation of stomach mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "positive regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903524 ! positive regulation of blood circulation
is_a: GO:1904344 ! regulation of gastric mucosal blood circulation
relationship: positively_regulates GO:1990768 ! gastric mucosal blood circulation

[Term]
id: GO:1904347
name: regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
relationship: regulates GO:1990770 ! small intestine smooth muscle contraction

[Term]
id: GO:1904348
name: negative regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction
relationship: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction

[Term]
id: GO:1904349
name: positive regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction
relationship: positively_regulates GO:1990770 ! small intestine smooth muscle contraction

[Term]
id: GO:1904350
name: regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0007039 ! protein catabolic process in the vacuole

[Term]
id: GO:1904351
name: negative regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
relationship: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole

[Term]
id: GO:1904352
name: positive regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
relationship: positively_regulates GO:0007039 ! protein catabolic process in the vacuole

[Term]
id: GO:1904353
name: regulation of telomere capping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "regulation of telomere end protection" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0016233 ! telomere capping

[Term]
id: GO:1904354
name: negative regulation of telomere capping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "down regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "inhibition of telomere capping" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere end protection" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomere end protection" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904353 ! regulation of telomere capping
relationship: negatively_regulates GO:0016233 ! telomere capping

[Term]
id: GO:1904355
name: positive regulation of telomere capping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "activation of telomere capping" NARROW [GOC:TermGenie]
synonym: "activation of telomere end protection" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere end protection" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904353 ! regulation of telomere capping
relationship: positively_regulates GO:0016233 ! telomere capping

[Term]
id: GO:1904356
name: regulation of telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0010833 ! telomere maintenance via telomere lengthening

[Term]
id: GO:1904357
name: negative regulation of telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "down regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "inhibition of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening
relationship: negatively_regulates GO:0010833 ! telomere maintenance via telomere lengthening

[Term]
id: GO:1904358
name: positive regulation of telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "activation of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie]
synonym: "up regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening
relationship: positively_regulates GO:0010833 ! telomere maintenance via telomere lengthening

[Term]
id: GO:1904359
name: regulation of spore germination
namespace: biological_process
alt_id: GO:0075006
def: "Any process that modulates the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]
synonym: "modulation of spore germination on or near host" NARROW []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0009847 ! spore germination

[Term]
id: GO:1904360
name: negative regulation of spore germination
namespace: biological_process
alt_id: GO:0075008
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]
synonym: "down regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "down-regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "downregulation of spore germination" EXACT [GOC:TermGenie]
synonym: "inhibition of spore germination" NARROW [GOC:TermGenie]
synonym: "negative regulation of spore germination on or near host" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904359 ! regulation of spore germination
relationship: negatively_regulates GO:0009847 ! spore germination

[Term]
id: GO:1904361
name: positive regulation of spore germination
namespace: biological_process
alt_id: GO:0075007
def: "Any process that activates or increases the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]
synonym: "activation of spore germination" NARROW [GOC:TermGenie]
synonym: "positive regulation of spore germination on or near host" NARROW []
synonym: "up regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "up-regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "upregulation of spore germination" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904359 ! regulation of spore germination
relationship: positively_regulates GO:0009847 ! spore germination

[Term]
id: GO:1904362
name: regulation of calcitonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0036161 ! calcitonin secretion

[Term]
id: GO:1904363
name: negative regulation of calcitonin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "down regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of calcitonin secretion" NARROW [GOC:TermGenie]
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
is_a: GO:1904362 ! regulation of calcitonin secretion
relationship: negatively_regulates GO:0036161 ! calcitonin secretion

[Term]
id: GO:1904364
name: positive regulation of calcitonin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "activation of calcitonin secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of calcitonin secretion" EXACT [GOC:TermGenie]
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
is_a: GO:1904362 ! regulation of calcitonin secretion
relationship: positively_regulates GO:0036161 ! calcitonin secretion

[Term]
id: GO:1904365
name: regulation of chemokinesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0042466 ! chemokinesis

[Term]
id: GO:1904366
name: negative regulation of chemokinesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "down regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chemokinesis" NARROW [GOC:TermGenie]
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:1904365 ! regulation of chemokinesis
relationship: negatively_regulates GO:0042466 ! chemokinesis

[Term]
id: GO:1904367
name: positive regulation of chemokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "activation of chemokinesis" NARROW [GOC:TermGenie]
synonym: "up regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chemokinesis" EXACT [GOC:TermGenie]
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:1904365 ! regulation of chemokinesis
relationship: positively_regulates GO:0042466 ! chemokinesis

[Term]
id: GO:1904368
name: regulation of sclerenchyma cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0014001 ! sclerenchyma cell differentiation

[Term]
id: GO:1904369
name: positive regulation of sclerenchyma cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534]
synonym: "up regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1904368 ! regulation of sclerenchyma cell differentiation
relationship: positively_regulates GO:0014001 ! sclerenchyma cell differentiation

[Term]
id: GO:1904370
name: regulation of protein localization to actin cortical patch
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
is_a: GO:1904776 ! regulation of protein localization to cell cortex
relationship: regulates GO:0044379 ! protein localization to actin cortical patch

[Term]
id: GO:1904371
name: negative regulation of protein localization to actin cortical patch
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "down regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
is_a: GO:1904370 ! regulation of protein localization to actin cortical patch
is_a: GO:1904777 ! negative regulation of protein localization to cell cortex
relationship: negatively_regulates GO:0044379 ! protein localization to actin cortical patch

[Term]
id: GO:1904372
name: positive regulation of protein localization to actin cortical patch
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "activation of protein localisation to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
is_a: GO:1904370 ! regulation of protein localization to actin cortical patch
is_a: GO:1904778 ! positive regulation of protein localization to cell cortex
relationship: positively_regulates GO:0044379 ! protein localization to actin cortical patch

[Term]
id: GO:1904373
name: response to kainic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904374
name: cellular response to kainic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904373 ! response to kainic acid

[Term]
id: GO:1904375
name: regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1904376
name: negative regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
relationship: negatively_regulates GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1904377
name: positive regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
relationship: positively_regulates GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1904378
name: maintenance of unfolded protein involved in ERAD pathway
namespace: biological_process
def: "Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303]
synonym: "chaperone holdase activity" RELATED [PMID:23417671]
synonym: "ERAD chaperone-like activity" RELATED [GOC:bf]
synonym: "holdase activity" RELATED [PMID:21636303]
synonym: "maintenance of unfolded protein during ERAD" RELATED [GOC:bf]
synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "maintenance of unfolded protein involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:0036506 ! maintenance of unfolded protein
relationship: part_of GO:0036503 ! ERAD pathway

[Term]
id: GO:1904379
name: obsolete protein localization to cytosolic proteasome complex involved in ERAD pathway
namespace: biological_process
def: "OBSOLETE. Any protein localization to cytosolic proteasome complex that is involved in ERAD pathway. Following their retrotranslocation out of the endoplasmic reticulum, protein substrates must be shuttled to the cytosolic proteasome for degradation." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303]
comment: This term was obsoleted because it has identical meaning to another term (positive regulation of ERAD pathway).
is_obsolete: true
replaced_by: GO:0036503

[Term]
id: GO:1904380
name: endoplasmic reticulum mannose trimming
namespace: biological_process
def: "Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC)." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]
synonym: "ER mannose trimming" EXACT [GOC:bf]
synonym: "ER protein alpha-1,2-demannosylation" EXACT [GOC:bf]
synonym: "glycoprotein mannose trimming in endoplasmic reticulum quality control compartment" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in ER quality control compartment" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in ER-derived quality control compartment" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in ERQC" RELATED [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in ER" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in ER quality control compartment" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in ER-derived quality control compartment" RELATED [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in ERQC" EXACT [GOC:TermGenie]
is_a: GO:0036508 ! protein alpha-1,2-demannosylation

[Term]
id: GO:1904381
name: Golgi apparatus mannose trimming
namespace: biological_process
def: "Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:10915796]
synonym: "glycoprotein mannose trimming in Golgi apparatus" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in Golgi complex" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in Golgi ribbon" RELATED [GOC:TermGenie]
synonym: "mannose trimming in cis-Golgi" NARROW [GOC:bf]
synonym: "mannose trimming in Golgi" BROAD [GOC:TermGenie]
synonym: "mannose trimming in Golgi apparatus" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in Golgi apparatus" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in Golgi complex" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in Golgi ribbon" NARROW [GOC:TermGenie]
is_a: GO:0006491 ! N-glycan processing
is_a: GO:0036508 ! protein alpha-1,2-demannosylation

[Term]
id: GO:1904382
name: mannose trimming involved in glycoprotein ERAD pathway
namespace: biological_process
def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]
subset: gocheck_obsoletion_candidate
synonym: "glycoprotein mannose trimming involved in ER-associated glycoprotein degradation" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD pathway" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming involved in gpERAD" RELATED [GOC:TermGenie]
synonym: "mannose trimming involved in misfolded or incompletely synthesized glycoprotein catabolic process" BROAD [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation involved in ER-associated glycoprotein degradation" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD pathway" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation involved in gpERAD" EXACT [GOC:TermGenie]
is_a: GO:0035977 ! protein deglycosylation involved in glycoprotein catabolic process
is_a: GO:0036508 ! protein alpha-1,2-demannosylation
relationship: part_of GO:0097466 ! ubiquitin-dependent glycoprotein ERAD pathway

[Term]
id: GO:1904383
name: response to sodium phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659]
is_a: GO:1902074 ! response to salt

[Term]
id: GO:1904384
name: cellular response to sodium phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659]
is_a: GO:1902075 ! cellular response to salt
is_a: GO:1904383 ! response to sodium phosphate

[Term]
id: GO:1904385
name: cellular response to angiotensin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [GO_REF:0000071, GOC:TermGenie, PMID:22982863]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990776 ! response to angiotensin

[Term]
id: GO:1904386
name: response to L-phenylalanine derivative
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904387
name: cellular response to L-phenylalanine derivative
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904386 ! response to L-phenylalanine derivative

[Term]
id: GO:1904388
name: obsolete negative regulation of ncRNA transcription associated with protein coding gene TSS/TES
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ncRNA transcription associated with protein coding gene TSS/TES." [GO_REF:0000058, GOC:TermGenie, PMID:20502517]
comment: The reason for obsoletion is that this term was added in error.
synonym: "downregulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904389
name: rod bipolar cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a rod bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:16914133]
is_a: GO:0060040 ! retinal bipolar neuron differentiation

[Term]
id: GO:1904390
name: cone retinal bipolar cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:24123365]
synonym: "cone bipolar cell differentiation" EXACT [PMID:14745032]
synonym: "retinal cone bipolar cell differentiation" EXACT []
is_a: GO:0060040 ! retinal bipolar neuron differentiation

[Term]
id: GO:1904391
name: response to ciliary neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904392
name: cellular response to ciliary neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904391 ! response to ciliary neurotrophic factor

[Term]
id: GO:1904393
name: regulation of skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1903909 ! regulation of receptor clustering
relationship: regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering

[Term]
id: GO:1904394
name: negative regulation of skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "down regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal muscle AChR clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie]
synonym: "negative regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "negative regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1903910 ! negative regulation of receptor clustering
is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering
relationship: negatively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering

[Term]
id: GO:1904395
name: positive regulation of skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "activation of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie]
synonym: "activation of skeletal muscle AChR clustering" NARROW [GOC:TermGenie]
synonym: "activation of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie]
synonym: "positive regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "positive regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1903911 ! positive regulation of receptor clustering
is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering
relationship: positively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering

[Term]
id: GO:1904396
name: regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0007528 ! neuromuscular junction development

[Term]
id: GO:1904397
name: negative regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:1904396 ! regulation of neuromuscular junction development
is_a: GO:1905809 ! negative regulation of synapse organization
relationship: negatively_regulates GO:0007528 ! neuromuscular junction development

[Term]
id: GO:1904398
name: positive regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "activation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1904396 ! regulation of neuromuscular junction development
relationship: positively_regulates GO:0007528 ! neuromuscular junction development

[Term]
id: GO:1904399
name: heparan sulfate binding
namespace: molecular_function
def: "Binding to heparan sulfate." [GO_REF:0000067, GOC:TermGenie, PMID:8567685]
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:1904400
name: response to Thyroid stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928]
is_a: GO:1904587 ! response to glycoprotein

[Term]
id: GO:1904401
name: cellular response to Thyroid stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928]
is_a: GO:1904400 ! response to Thyroid stimulating hormone
is_a: GO:1904588 ! cellular response to glycoprotein

[Term]
id: GO:1904402
name: response to nocodazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904403
name: cellular response to nocodazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904402 ! response to nocodazole

[Term]
id: GO:1904404
name: response to formaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904405
name: cellular response to formaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109]
is_a: GO:0110096 ! cellular response to aldehyde
is_a: GO:1904404 ! response to formaldehyde

[Term]
id: GO:1904406
name: negative regulation of nitric oxide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "down regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of nitric oxide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nitric oxide metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0080164 ! regulation of nitric oxide metabolic process
relationship: negatively_regulates GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:1904407
name: positive regulation of nitric oxide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "activation of nitric oxide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of nitric oxide metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0080164 ! regulation of nitric oxide metabolic process
relationship: positively_regulates GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:1904408
name: melatonin binding
namespace: molecular_function
def: "Binding to melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923]
is_a: GO:0033218 ! amide binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:1904409
name: regulation of secretory granule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0033363 ! secretory granule organization

[Term]
id: GO:1904410
name: negative regulation of secretory granule organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
relationship: negatively_regulates GO:0033363 ! secretory granule organization

[Term]
id: GO:1904411
name: positive regulation of secretory granule organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
relationship: positively_regulates GO:0033363 ! secretory granule organization

[Term]
id: GO:1904412
name: regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0003231 ! cardiac ventricle development

[Term]
id: GO:1904413
name: negative regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
relationship: negatively_regulates GO:0003231 ! cardiac ventricle development

[Term]
id: GO:1904414
name: positive regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
relationship: positively_regulates GO:0003231 ! cardiac ventricle development

[Term]
id: GO:1904415
name: regulation of xenophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]
comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype).
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0098792 ! xenophagy

[Term]
id: GO:1904416
name: negative regulation of xenophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]
comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype).
synonym: "down regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of xenophagy" NARROW [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:1904415 ! regulation of xenophagy
relationship: negatively_regulates GO:0098792 ! xenophagy

[Term]
id: GO:1904417
name: positive regulation of xenophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]
comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype).
synonym: "activation of xenophagy" NARROW [GOC:TermGenie]
synonym: "up regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of xenophagy" EXACT [GOC:TermGenie]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:1904415 ! regulation of xenophagy
relationship: positively_regulates GO:0098792 ! xenophagy

[Term]
id: GO:1904418
name: regulation of telomeric loop formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of t-loop formation" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0031627 ! telomeric loop formation

[Term]
id: GO:1904419
name: negative regulation of telomeric loop formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "downregulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "inhibition of t-loop biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of t-loop formation" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric loop formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of t-loop formation" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904418 ! regulation of telomeric loop formation
relationship: negatively_regulates GO:0031627 ! telomeric loop formation

[Term]
id: GO:1904420
name: positive regulation of telomeric loop formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of t-loop biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of t-loop formation" NARROW [GOC:TermGenie]
synonym: "activation of telomeric loop formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "up regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "upregulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric loop formation" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904418 ! regulation of telomeric loop formation
relationship: positively_regulates GO:0031627 ! telomeric loop formation

[Term]
id: GO:1904421
name: response to D-galactosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904422
name: cellular response to D-galactosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904421 ! response to D-galactosamine

[Term]
id: GO:1904423
name: dehydrodolichyl diphosphate synthase complex
namespace: cellular_component
def: "A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056]
is_a: GO:0032476 ! polyprenyl diphosphate synthase complex

[Term]
id: GO:1904424
name: regulation of GTP binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:1904425
name: negative regulation of GTP binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
subset: gocheck_do_not_annotate
synonym: "down regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "downregulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "inhibition of GTP binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1904424 ! regulation of GTP binding

[Term]
id: GO:1904426
name: positive regulation of GTP binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
subset: gocheck_do_not_annotate
synonym: "activation of GTP binding" NARROW [GOC:TermGenie]
synonym: "up regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "upregulation of GTP binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1904424 ! regulation of GTP binding

[Term]
id: GO:1904427
name: positive regulation of calcium ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:22910094]
synonym: "activation of calcium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of calcium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "activation of transmembrane calcium transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
relationship: positively_regulates GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:1904428
name: negative regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation." [GO_REF:0000058, GOC:TermGenie, PMID:23886946]
synonym: "down regulation of tubulin deacetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tubulin deacetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of tubulin deacetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of tubulin deacetylation" NARROW [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0090043 ! regulation of tubulin deacetylation
relationship: negatively_regulates GO:0090042 ! tubulin deacetylation

[Term]
id: GO:1904429
name: regulation of t-circle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of telomeric circle formation" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0090656 ! t-circle formation

[Term]
id: GO:1904430
name: negative regulation of t-circle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of t-circle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric circle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomeric circle formation" EXACT [GOC:TermGenie]
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1904429 ! regulation of t-circle formation
relationship: negatively_regulates GO:0090656 ! t-circle formation

[Term]
id: GO:1904431
name: positive regulation of t-circle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of t-circle formation" NARROW [GOC:TermGenie]
synonym: "activation of telomeric circle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric circle formation" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1904429 ! regulation of t-circle formation
relationship: positively_regulates GO:0090656 ! t-circle formation

[Term]
id: GO:1904432
name: regulation of ferrous iron binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:1904433
name: negative regulation of ferrous iron binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "down regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "inhibition of ferrous iron binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1904432 ! regulation of ferrous iron binding

[Term]
id: GO:1904434
name: positive regulation of ferrous iron binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "activation of ferrous iron binding" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrous iron binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1904432 ! regulation of ferrous iron binding

[Term]
id: GO:1904435
name: regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:1904436
name: negative regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "down regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of transferrin receptor binding" NARROW [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1904435 ! regulation of transferrin receptor binding

[Term]
id: GO:1904437
name: positive regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "activation of transferrin receptor binding" NARROW [GOC:TermGenie]
synonym: "up regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of transferrin receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1904435 ! regulation of transferrin receptor binding

[Term]
id: GO:1904438
name: regulation of iron ion import across plasma membrane
namespace: biological_process
alt_id: GO:1903989
def: "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "regulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "regulation of ferrous iron import across plasma membrane" RELATED []
synonym: "regulation of ferrous iron import into cell" RELATED []
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0098711 ! iron ion import across plasma membrane

[Term]
id: GO:1904439
name: negative regulation of iron ion import across plasma membrane
namespace: biological_process
alt_id: GO:1903990
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "down regulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "down regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie]
synonym: "down-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "down-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie]
synonym: "downregulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "downregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie]
synonym: "inhibition of ferrous ion import into cell" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "negative regulation of ferrous iron import across plasma membrane" RELATED []
synonym: "negative regulation of ferrous iron import into cell" RELATED []
is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport
is_a: GO:1904438 ! regulation of iron ion import across plasma membrane
relationship: negatively_regulates GO:0098711 ! iron ion import across plasma membrane

[Term]
id: GO:1904440
name: positive regulation of iron ion import across plasma membrane
namespace: biological_process
alt_id: GO:1903991
def: "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "activation of ferrous ion import into cell" NARROW [GOC:TermGenie]
synonym: "activation of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "positive regulation of ferrous iron import across plasma membrane" RELATED []
synonym: "positive regulation of ferrous iron import into cell" RELATED []
synonym: "up regulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "up regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie]
synonym: "up-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "up-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie]
synonym: "upregulation of ferrous ion import into cell" RELATED [GOC:TermGenie]
synonym: "upregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie]
is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport
is_a: GO:1904438 ! regulation of iron ion import across plasma membrane
relationship: positively_regulates GO:0098711 ! iron ion import across plasma membrane

[Term]
id: GO:1904441
name: regulation of thyroid gland epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383]
synonym: "regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:1990789 ! thyroid gland epithelial cell proliferation

[Term]
id: GO:1904442
name: negative regulation of thyroid gland epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383]
synonym: "down regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "down regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "down regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "down-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "down-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "downregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "downregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation
relationship: negatively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation

[Term]
id: GO:1904443
name: positive regulation of thyroid gland epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383]
synonym: "activation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "up-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "up-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "upregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "upregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation
relationship: positively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation

[Term]
id: GO:1904444
name: regulation of establishment of Sertoli cell barrier
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314]
synonym: "regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of SCB" EXACT [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0097368 ! establishment of Sertoli cell barrier

[Term]
id: GO:1904445
name: negative regulation of establishment of Sertoli cell barrier
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314]
synonym: "down regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of blood-testis barrier" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of BTB" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of SCB" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of SCB" EXACT [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0097368 ! establishment of Sertoli cell barrier

[Term]
id: GO:1904446
name: positive regulation of establishment of Sertoli cell barrier
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314]
synonym: "activation of establishment of blood-testis barrier" NARROW [GOC:TermGenie]
synonym: "activation of establishment of BTB" NARROW [GOC:TermGenie]
synonym: "activation of establishment of SCB" NARROW [GOC:TermGenie]
synonym: "activation of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0097368 ! establishment of Sertoli cell barrier

[Term]
id: GO:1904447
name: folate import across plasma membrane
namespace: biological_process
def: "The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:19762432]
synonym: "folate import into cell" EXACT [GOC:hal]
synonym: "folic acid import across plasma membrane" RELATED []
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:0098838 ! folate transmembrane transport

[Term]
id: GO:1904448
name: regulation of aspartate secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903530 ! regulation of secretion by cell
relationship: regulates GO:0061528 ! aspartate secretion

[Term]
id: GO:1904449
name: negative regulation of aspartate secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602]
synonym: "down regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of aspartate secretion" NARROW [GOC:TermGenie]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903531 ! negative regulation of secretion by cell
is_a: GO:1904448 ! regulation of aspartate secretion
relationship: negatively_regulates GO:0061528 ! aspartate secretion

[Term]
id: GO:1904450
name: positive regulation of aspartate secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602]
synonym: "activation of aspartate secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate secretion" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903532 ! positive regulation of secretion by cell
is_a: GO:1904448 ! regulation of aspartate secretion
relationship: positively_regulates GO:0061528 ! aspartate secretion

[Term]
id: GO:1904451
name: regulation of potassium:proton exchanging ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793]
subset: gocheck_obsoletion_candidate
synonym: "regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "regulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen:potassium-exchanging ATPase activity" EXACT []
synonym: "regulation of proton pump activity" BROAD [GOC:TermGenie]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0043462 ! regulation of ATP-dependent activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity

[Term]
id: GO:1904452
name: obsolete negative regulation of potassium:proton exchanging ATPase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down regulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "downregulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "inhibition of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of H+-K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H+/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H+/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H,K-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "negative regulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen:potassium-exchanging ATPase activity" EXACT []
is_obsolete: true

[Term]
id: GO:1904453
name: obsolete positive regulation of potassium:proton exchanging ATPase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "activation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "activation of H+-K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H+/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H+/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H,K-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "positive regulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen:potassium-exchanging ATPase activity" EXACT []
synonym: "up regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up regulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "upregulation of gastric H+/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H+/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H+/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904456
name: negative regulation of neuronal action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie]
synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0051970 ! negative regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
relationship: negatively_regulates GO:0019228 ! neuronal action potential

[Term]
id: GO:1904457
name: positive regulation of neuronal action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "activation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0051971 ! positive regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
relationship: positively_regulates GO:0019228 ! neuronal action potential

[Term]
id: GO:1904458
name: regulation of substance P secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:1990772 ! substance P secretion

[Term]
id: GO:1904459
name: negative regulation of substance P secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "down regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of substance P secretion" NARROW [GOC:TermGenie]
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
is_a: GO:1904458 ! regulation of substance P secretion
relationship: negatively_regulates GO:1990772 ! substance P secretion

[Term]
id: GO:1904460
name: positive regulation of substance P secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "activation of substance P secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P secretion" EXACT [GOC:TermGenie]
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
is_a: GO:1904458 ! regulation of substance P secretion
relationship: positively_regulates GO:1990772 ! substance P secretion

[Term]
id: GO:1904461
name: ergosteryl 3-beta-D-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408]
synonym: "ergosteryl 3-beta-D-glucoside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:1904462
name: ergosteryl 3-beta-D-glucoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408]
synonym: "ergosteryl 3-beta-D-glucoside breakdown" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside catabolism" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside degradation" EXACT [GOC:TermGenie]
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016136 ! saponin catabolic process
is_a: GO:1901805 ! beta-glucoside catabolic process
is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process

[Term]
id: GO:1904463
name: ergosteryl 3-beta-D-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408]
synonym: "ergosteryl 3-beta-D-glucoside anabolism" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside biosynthesis" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside formation" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016135 ! saponin biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process
is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process

[Term]
id: GO:1904464
name: regulation of matrix metallopeptidase secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "regulation of MMP secretion" EXACT [GOC:TermGenie]
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:1990773 ! matrix metallopeptidase secretion

[Term]
id: GO:1904465
name: negative regulation of matrix metallopeptidase secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "down regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of matrix metallopeptidase secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of MMP secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of MMP secretion" EXACT [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion
relationship: negatively_regulates GO:1990773 ! matrix metallopeptidase secretion

[Term]
id: GO:1904466
name: positive regulation of matrix metallopeptidase secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "activation of matrix metallopeptidase secretion" NARROW [GOC:TermGenie]
synonym: "activation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "activation of MMP secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of MMP secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion
relationship: positively_regulates GO:1990773 ! matrix metallopeptidase secretion

[Term]
id: GO:1904470
name: regulation of endothelin production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin secretion" NARROW []
synonym: "regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:1990775 ! endothelin production

[Term]
id: GO:1904471
name: negative regulation of endothelin production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "down regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin secretion" NARROW []
synonym: "negative regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1904470 ! regulation of endothelin production
relationship: negatively_regulates GO:1990775 ! endothelin production

[Term]
id: GO:1904472
name: positive regulation of endothelin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "activation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "activation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin secretion" NARROW []
synonym: "positive regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1904470 ! regulation of endothelin production
relationship: positively_regulates GO:1990775 ! endothelin production

[Term]
id: GO:1904473
name: response to L-dopa
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901700 ! response to oxygen-containing compound
is_a: GO:1904386 ! response to L-phenylalanine derivative

[Term]
id: GO:1904474
name: cellular response to L-dopa
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904387 ! cellular response to L-phenylalanine derivative
is_a: GO:1904473 ! response to L-dopa

[Term]
id: GO:1904475
name: regulation of small GTPase binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
subset: gocheck_do_not_annotate
synonym: "regulation of Ras GTPase binding" NARROW []
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:1904476
name: negative regulation of small GTPase binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
subset: gocheck_do_not_annotate
synonym: "down regulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "downregulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "inhibition of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ras GTPase binding" NARROW []
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904475 ! regulation of small GTPase binding

[Term]
id: GO:1904477
name: positive regulation of small GTPase binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
subset: gocheck_do_not_annotate
synonym: "activation of Ras GTPase binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of Ras GTPase binding" NARROW []
synonym: "up regulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "upregulation of small GTPase binding" EXACT [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904475 ! regulation of small GTPase binding

[Term]
id: GO:1904478
name: regulation of intestinal absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0050892 ! intestinal absorption

[Term]
id: GO:1904479
name: negative regulation of intestinal absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]
synonym: "down regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "down-regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "downregulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "inhibition of intestinal absorption" NARROW [GOC:TermGenie]
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:1904478 ! regulation of intestinal absorption
relationship: negatively_regulates GO:0050892 ! intestinal absorption

[Term]
id: GO:1904480
name: positive regulation of intestinal absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]
synonym: "activation of intestinal absorption" NARROW [GOC:TermGenie]
synonym: "up regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "up-regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "upregulation of intestinal absorption" EXACT [GOC:TermGenie]
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:1904478 ! regulation of intestinal absorption
relationship: positively_regulates GO:0050892 ! intestinal absorption

[Term]
id: GO:1904481
name: response to tetrahydrofolate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904482
name: cellular response to tetrahydrofolate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904481 ! response to tetrahydrofolate

[Term]
id: GO:1904483
name: synthetic cannabinoid binding
namespace: molecular_function
def: "Binding to synthetic cannabinoid." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10700562]
is_a: GO:0005488 ! binding

[Term]
id: GO:1904484
name: cloacal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421]
is_a: GO:0048732 ! gland development

[Term]
id: GO:1904486
name: obsolete response to 17alpha-ethynylestradiol
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421]
comment: The reason for obsoletion is that this term represent an assay and not a real GO process.
is_obsolete: true
replaced_by: GO:0043627

[Term]
id: GO:1904487
name: obsolete cellular response to 17alpha-ethynylestradiol
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421]
comment: The reason for obsoletion is that this term represent an assay and not a real GO process.
is_obsolete: true
replaced_by: GO:0071391

[Term]
id: GO:1904488
name: obsolete regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of reactive oxygen species metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:1904489
name: obsolete regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of reactive oxygen species metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:1904490
name: obsolete negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of mitochondrial unfolded protein response." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0000122

[Term]
id: GO:1904491
name: protein localization to ciliary transition zone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]
synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium

[Term]
id: GO:1904492
name: Ac-Asp-Glu binding
namespace: molecular_function
def: "Binding to Ac-Asp-Glu." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754]
is_a: GO:0043168 ! anion binding
is_a: GO:1900750 ! oligopeptide binding

[Term]
id: GO:1904493
name: tetrahydrofolyl-poly(glutamate) polymer binding
namespace: molecular_function
def: "Binding to tetrahydrofolyl-poly(glutamate) polymer." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754]
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:1904494
name: regulation of substance P secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051]
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:1904458 ! regulation of substance P secretion
relationship: regulates GO:1990793 ! substance P secretion, neurotransmission

[Term]
id: GO:1904495
name: negative regulation of substance P secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051]
synonym: "down regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of substance P secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:1904459 ! negative regulation of substance P secretion
is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission
relationship: negatively_regulates GO:1990793 ! substance P secretion, neurotransmission

[Term]
id: GO:1904496
name: positive regulation of substance P secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051]
synonym: "activation of substance P secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:1904460 ! positive regulation of substance P secretion
is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission
relationship: positively_regulates GO:1990793 ! substance P secretion, neurotransmission

[Term]
id: GO:1904498
name: protein localization to mitotic actomyosin contractile ring
namespace: biological_process
def: "Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25688133]
synonym: "protein localisation to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "protein localisation to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "protein localization to actomyosin contractile ring during mitotic cytokinesis" RELATED []
synonym: "protein localization to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT []
is_a: GO:1903047 ! mitotic cell cycle process
is_a: GO:1990179 ! protein localization to actomyosin contractile ring
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:1904499
name: obsolete regulation of chromatin-mediated maintenance of transcription
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
comment: This term was obsoleted because it represents a readout.
is_obsolete: true

[Term]
id: GO:1904500
name: obsolete negative regulation of chromatin-mediated maintenance of transcription
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
comment: This term was obsoleted because it represents a readout.
synonym: "down regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "inhibition of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904501
name: obsolete positive regulation of chromatin-mediated maintenance of transcription
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
comment: This term was obsoleted because it represents a readout.
synonym: "activation of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie]
synonym: "up regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904502
name: regulation of lipophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]
is_a: GO:0016241 ! regulation of macroautophagy
relationship: regulates GO:0061724 ! lipophagy

[Term]
id: GO:1904503
name: negative regulation of lipophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]
synonym: "down regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of lipophagy" NARROW [GOC:TermGenie]
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:1904502 ! regulation of lipophagy
relationship: negatively_regulates GO:0061724 ! lipophagy

[Term]
id: GO:1904504
name: positive regulation of lipophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]
synonym: "activation of lipophagy" NARROW [GOC:TermGenie]
synonym: "up regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of lipophagy" EXACT [GOC:TermGenie]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:1904502 ! regulation of lipophagy
relationship: positively_regulates GO:0061724 ! lipophagy

[Term]
id: GO:1904505
name: regulation of telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0043247 ! telomere maintenance in response to DNA damage

[Term]
id: GO:1904506
name: negative regulation of telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage
relationship: negatively_regulates GO:0043247 ! telomere maintenance in response to DNA damage

[Term]
id: GO:1904507
name: positive regulation of telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie]
synonym: "activation of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage
relationship: positively_regulates GO:0043247 ! telomere maintenance in response to DNA damage

[Term]
id: GO:1904508
name: regulation of protein localization to basolateral plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]
synonym: "regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: regulates GO:1903361 ! protein localization to basolateral plasma membrane

[Term]
id: GO:1904509
name: negative regulation of protein localization to basolateral plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]
synonym: "down regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane
is_a: GO:1905476 ! negative regulation of protein localization to membrane
relationship: negatively_regulates GO:1903361 ! protein localization to basolateral plasma membrane

[Term]
id: GO:1904510
name: positive regulation of protein localization to basolateral plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]
synonym: "activation of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane
is_a: GO:1905477 ! positive regulation of protein localization to membrane
relationship: positively_regulates GO:1903361 ! protein localization to basolateral plasma membrane

[Term]
id: GO:1904511
name: cytoplasmic microtubule plus-end
namespace: cellular_component
def: "Any microtubule plus-end that is part of a cytoplasmic microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:15772152]
synonym: "growing microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie]
synonym: "growing microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie]
synonym: "microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie]
synonym: "microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie]
synonym: "microtubule plus-end of cytoplasmic microtubule" EXACT [GOC:TermGenie]
synonym: "microtubule plus-end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie]
is_a: GO:0035371 ! microtubule plus-end
relationship: part_of GO:0005881 ! cytoplasmic microtubule

[Term]
id: GO:1904512
name: regulation of initiation of premeiotic DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897]
synonym: "regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
is_a: GO:0030174 ! regulation of DNA-templated DNA replication initiation
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
is_a: GO:0051445 ! regulation of meiotic cell cycle
relationship: regulates GO:1902974 ! meiotic DNA replication initiation

[Term]
id: GO:1904513
name: negative regulation of initiation of premeiotic DNA replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897]
synonym: "down regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "down regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "downregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "inhibition of premeiotic DNA replication initiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
is_a: GO:0032297 ! negative regulation of DNA-templated DNA replication initiation
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication
is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication
relationship: negatively_regulates GO:1902974 ! meiotic DNA replication initiation

[Term]
id: GO:1904514
name: positive regulation of initiation of premeiotic DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897]
synonym: "activation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "activation of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "activation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "activation of premeiotic DNA replication initiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "up regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "up regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "upregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication
is_a: GO:0032298 ! positive regulation of DNA-templated DNA replication initiation
is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:1902974 ! meiotic DNA replication initiation

[Term]
id: GO:1904515
name: positive regulation of TORC2 signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25590601]
synonym: "activation of TORC2 signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of TORC2 signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC2 signaling" EXACT [GOC:TermGenie]
is_a: GO:0032008 ! positive regulation of TOR signaling
is_a: GO:1903939 ! regulation of TORC2 signaling
relationship: positively_regulates GO:0038203 ! TORC2 signaling

[Term]
id: GO:1904516
name: myofibroblast cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a myofibroblast cell." [GO_REF:0000085, GOC:TermGenie, PMID:23026405]
synonym: "MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:1904517
name: obsolete MgATP(2-) binding
namespace: molecular_function
def: "OBSOLETE. Binding to MgATP(2-)." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:20086079]
comment: This term was obsolsted because it is equivalent to GO:0005524 ; ATP binding.
is_obsolete: true
replaced_by: GO:0005524

[Term]
id: GO:1904518
name: protein localization to cytoplasmic microtubule plus-end
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at a cytoplasmic microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:15772152]
synonym: "protein localisation in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie]
synonym: "protein localization in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie]
is_a: GO:1904825 ! protein localization to microtubule plus-end
is_a: GO:1905755 ! protein localization to cytoplasmic microtubule

[Term]
id: GO:1904519
name: protein localization to microtubule minus-end
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at a microtubule minus-end." [GO_REF:0000087, GOC:TermGenie, PMID:25987607]
synonym: "protein localisation in microtubule minus-end" EXACT [GOC:TermGenie]
synonym: "protein localisation to microtubule minus-end" EXACT [GOC:TermGenie]
synonym: "protein localization in microtubule minus-end" EXACT [GOC:TermGenie]
is_a: GO:1905725 ! protein localization to microtubule end

[Term]
id: GO:1904520
name: regulation of myofibroblast cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034]
synonym: "regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:1904516 ! myofibroblast cell apoptotic process

[Term]
id: GO:1904521
name: negative regulation of myofibroblast cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034]
synonym: "down regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of MFB apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process
relationship: negatively_regulates GO:1904516 ! myofibroblast cell apoptotic process

[Term]
id: GO:1904522
name: positive regulation of myofibroblast cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034]
synonym: "activation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of MFB apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process
relationship: positively_regulates GO:1904516 ! myofibroblast cell apoptotic process

[Term]
id: GO:1904523
name: regulation of DNA amplification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783]
is_a: GO:2000278 ! regulation of DNA biosynthetic process
relationship: regulates GO:0006277 ! DNA amplification

[Term]
id: GO:1904524
name: negative regulation of DNA amplification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783]
synonym: "down regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA amplification" NARROW [GOC:TermGenie]
is_a: GO:1904523 ! regulation of DNA amplification
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
relationship: negatively_regulates GO:0006277 ! DNA amplification

[Term]
id: GO:1904525
name: positive regulation of DNA amplification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783]
synonym: "activation of DNA amplification" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA amplification" EXACT [GOC:TermGenie]
is_a: GO:1904523 ! regulation of DNA amplification
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
relationship: positively_regulates GO:0006277 ! DNA amplification

[Term]
id: GO:1904526
name: regulation of microtubule binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:1904527
name: negative regulation of microtubule binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "down regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "down regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "down-regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "downregulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "downregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "inhibition of microtubule binding" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "inhibition of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "negative regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904526 ! regulation of microtubule binding

[Term]
id: GO:1904528
name: positive regulation of microtubule binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "activation of microtubule binding" NARROW [GOC:TermGenie]
synonym: "activation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "activation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "positive regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "up regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "up regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "up-regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "upregulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "upregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904526 ! regulation of microtubule binding

[Term]
id: GO:1904529
name: regulation of actin filament binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "regulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904616 ! regulation of actin binding

[Term]
id: GO:1904530
name: negative regulation of actin filament binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "down regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "down regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "down regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "downregulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "downregulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "inhibition of actin filament binding" NARROW [GOC:TermGenie]
synonym: "inhibition of F-actin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904529 ! regulation of actin filament binding
is_a: GO:1904617 ! negative regulation of actin binding

[Term]
id: GO:1904531
name: positive regulation of actin filament binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "activation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "activation of actin filament binding" NARROW [GOC:TermGenie]
synonym: "activation of F-actin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "up regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "up regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "up regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "upregulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "upregulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904529 ! regulation of actin filament binding
is_a: GO:1904618 ! positive regulation of actin binding

[Term]
id: GO:1904532
name: obsolete ATP-dependent microtubule motor activity, minus-end-directed involved in microtubule-based movement
namespace: molecular_function
def: "OBSOLETE. Any ATP-dependent microtubule motor activity, minus-end-directed that is involved in microtubule-based movement." [GO_REF:0000061, GOC:TermGenie, PMID:25987607]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1904533
name: regulation of telomeric loop disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of T loop disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0090657 ! telomeric loop disassembly

[Term]
id: GO:1904534
name: negative regulation of telomeric loop disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of T loop disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric loop disassembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of T loop disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904533 ! regulation of telomeric loop disassembly
relationship: negatively_regulates GO:0090657 ! telomeric loop disassembly

[Term]
id: GO:1904535
name: positive regulation of telomeric loop disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of T loop disassembly" NARROW [GOC:TermGenie]
synonym: "activation of telomeric loop disassembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904533 ! regulation of telomeric loop disassembly
relationship: positively_regulates GO:0090657 ! telomeric loop disassembly

[Term]
id: GO:1904536
name: regulation of mitotic telomere tethering at nuclear periphery
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery

[Term]
id: GO:1904537
name: negative regulation of mitotic telomere tethering at nuclear periphery
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349]
synonym: "down regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic telomere tethering at nuclear periphery" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904536 ! regulation of mitotic telomere tethering at nuclear periphery
relationship: negatively_regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery

[Term]
id: GO:1904538
name: regulation of glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]
synonym: "regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0006110 ! regulation of glycolytic process
relationship: regulates GO:0061615 ! glycolytic process through fructose-6-phosphate

[Term]
id: GO:1904539
name: negative regulation of glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]
synonym: "down regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "down regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "downregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "downregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "inhibition of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "inhibition of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0045820 ! negative regulation of glycolytic process
is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate
relationship: negatively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate

[Term]
id: GO:1904540
name: positive regulation of glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]
synonym: "activation of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "activation of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "upregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "upregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0045821 ! positive regulation of glycolytic process
is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate
relationship: positively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate

[Term]
id: GO:1904541
name: fungal-type cell wall disassembly involved in conjugation with cellular fusion
namespace: biological_process
def: "Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion." [GO_REF:0000060, GOC:TermGenie, PMID:25825517]
synonym: "fungal-type cell wall disassembly involved in cell fusion" RELATED [GOC:TermGenie]
synonym: "fungal-type cell wall disassembly involved in mating" RELATED [GOC:TermGenie]
is_a: GO:0070871 ! cell wall organization involved in conjugation with cellular fusion
is_a: GO:0071853 ! fungal-type cell wall disassembly

[Term]
id: GO:1904542
name: regulation of free ubiquitin chain polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]
comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype).
is_a: GO:0032271 ! regulation of protein polymerization
relationship: regulates GO:0010994 ! free ubiquitin chain polymerization

[Term]
id: GO:1904543
name: negative regulation of free ubiquitin chain polymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]
comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype).
synonym: "down regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "inhibition of free ubiquitin chain polymerization" NARROW [GOC:TermGenie]
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization
relationship: negatively_regulates GO:0010994 ! free ubiquitin chain polymerization

[Term]
id: GO:1904544
name: positive regulation of free ubiquitin chain polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]
comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype).
synonym: "activation of free ubiquitin chain polymerization" NARROW [GOC:TermGenie]
synonym: "up regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization
relationship: positively_regulates GO:0010994 ! free ubiquitin chain polymerization

[Term]
id: GO:1904546
name: obsolete negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway
namespace: biological_process
def: "OBSOLETE. Any negative regulation of cAMP-dependent protein kinase activity that is involved in negative regulation of glucose mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:21118717]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904547
name: regulation of cellular response to glucose starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to glucose starvation." [GO_REF:0000058, GOC:TermGenie, PMID:21118717]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0042149 ! cellular response to glucose starvation

[Term]
id: GO:1904550
name: response to arachidonate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163]
synonym: "response to arachidonic acid" EXACT []
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:1904551
name: cellular response to arachidonate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163]
synonym: "cellular response to arachidonic acid" EXACT []
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:1904550 ! response to arachidonate

[Term]
id: GO:1904552
name: regulation of chemotaxis to arachidonate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163]
synonym: "regulation of chemotaxis to arachidonic acid" EXACT []
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0034670 ! chemotaxis to arachidonate

[Term]
id: GO:1904553
name: negative regulation of chemotaxis to arachidonate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163]
synonym: "down regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie]
synonym: "negative regulation of chemotaxis to arachidonic acid" EXACT []
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1904552 ! regulation of chemotaxis to arachidonate
relationship: negatively_regulates GO:0034670 ! chemotaxis to arachidonate

[Term]
id: GO:1904554
name: positive regulation of chemotaxis to arachidonate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163]
synonym: "activation of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie]
synonym: "positive regulation of chemotaxis to arachidonic acid" EXACT []
synonym: "up regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1904552 ! regulation of chemotaxis to arachidonate
relationship: positively_regulates GO:0034670 ! chemotaxis to arachidonate

[Term]
id: GO:1904555
name: L-proline transmembrane transport
namespace: biological_process
def: "The directed movement of L-proline across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015824 ! proline transport
is_a: GO:0035524 ! proline transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1904556
name: L-tryptophan transmembrane transport
namespace: biological_process
def: "The directed movement of L-tryptophan across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
is_a: GO:0015827 ! tryptophan transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1904557
name: L-alanine transmembrane transport
namespace: biological_process
def: "The directed movement of L-alanine across a membrane by means of some agent such as a transporter or a pore." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
is_a: GO:0015808 ! L-alanine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1904558
name: response to dextromethorphan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0014072 ! response to isoquinoline alkaloid
is_a: GO:0045472 ! response to ether

[Term]
id: GO:1904559
name: cellular response to dextromethorphan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid
is_a: GO:0071362 ! cellular response to ether
is_a: GO:1904558 ! response to dextromethorphan

[Term]
id: GO:1904560
name: response to diphenidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904561
name: cellular response to diphenidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904560 ! response to diphenidol

[Term]
id: GO:1904562
name: phosphatidylinositol 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588]
synonym: "phosphatidylinositol 5-phosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:1904563
name: phosphatidylinositol 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588]
synonym: "phosphatidylinositol 5-phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "phosphatidylinositol 5-phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "phosphatidylinositol 5-phosphate formation" EXACT [GOC:TermGenie]
synonym: "phosphatidylinositol 5-phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process
is_a: GO:1904562 ! phosphatidylinositol 5-phosphate metabolic process

[Term]
id: GO:1904564
name: cytosolic [4Fe-4S] assembly scaffold complex
namespace: cellular_component
def: "A heterotetrameric complex with weak ATPase activity that is capable of scaffolding a 4Fe-4S (iron-sulfur) cluster. In yeast, the subunits are Nbp35 and Cfd1. In humans, the subunits are NUBP1 and NUBP2." [GO_REF:0000088, GOC:bhm, GOC:rb, PMID:26195633, PMID:34660592]
synonym: "CIA scaffold complex" EXACT [PMID:34660592]
synonym: "cytosolic scaffold protein complex" RELATED [PMID:34660592]
synonym: "Nbp35-Cfd1 ATPase complex" EXACT []
is_a: GO:1904949 ! ATPase complex
is_a: GO:1990229 ! iron-sulfur cluster assembly complex

[Term]
id: GO:1904565
name: response to 1-oleoyl-sn-glycerol 3-phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919]
synonym: "response to 1-oleoyl lysophosphatidic acid" EXACT []
synonym: "response to LPA" EXACT []
synonym: "response to lysophosphatidic acid" EXACT []
synonym: "response to oleoyl lysophosphatidic acid" EXACT []
synonym: "response to oleoyl-L-alpha-lysophosphatidic acid" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904566
name: cellular response to 1-oleoyl-sn-glycerol 3-phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919]
synonym: "cellular response to 1-oleoyl lysophosphatidic acid" EXACT []
synonym: "cellular response to LPA" EXACT []
synonym: "cellular response to lysophosphatidic acid" EXACT []
synonym: "cellular response to oleoyl lysophosphatidic acid" EXACT []
synonym: "cellular response to oleoyl-L-alpha-lysophosphatidic acid" EXACT []
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904565 ! response to 1-oleoyl-sn-glycerol 3-phosphate

[Term]
id: GO:1904567
name: response to wortmannin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186]
synonym: "response to wartmannin" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1904568
name: cellular response to wortmannin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186]
synonym: "cellular response to wartmannin" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904567 ! response to wortmannin

[Term]
id: GO:1904569
name: regulation of selenocysteine incorporation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449]
is_a: GO:0006448 ! regulation of translational elongation
relationship: regulates GO:0001514 ! selenocysteine incorporation

[Term]
id: GO:1904570
name: negative regulation of selenocysteine incorporation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449]
synonym: "down regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "downregulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "inhibition of selenocysteine incorporation" NARROW [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:1904569 ! regulation of selenocysteine incorporation
relationship: negatively_regulates GO:0001514 ! selenocysteine incorporation

[Term]
id: GO:1904571
name: positive regulation of selenocysteine incorporation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449]
synonym: "activation of selenocysteine incorporation" NARROW [GOC:TermGenie]
synonym: "up regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "upregulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:1904569 ! regulation of selenocysteine incorporation
relationship: positively_regulates GO:0001514 ! selenocysteine incorporation

[Term]
id: GO:1904572
name: negative regulation of mRNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "down regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA binding" NARROW [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
is_a: GO:1905215 ! negative regulation of RNA binding

[Term]
id: GO:1904573
name: regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "regulation of SECIS binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding

[Term]
id: GO:1904574
name: negative regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "down regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "down regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "downregulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "downregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "inhibition of SECIS binding" NARROW [GOC:TermGenie]
synonym: "inhibition of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SECIS binding" EXACT [GOC:TermGenie]
is_a: GO:1904572 ! negative regulation of mRNA binding
is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding

[Term]
id: GO:1904575
name: positive regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "activation of SECIS binding" NARROW [GOC:TermGenie]
synonym: "activation of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "upregulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "upregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding

[Term]
id: GO:1904576
name: obsolete response to tunicamycin
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1904577
name: obsolete cellular response to tunicamycin
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1904578
name: obsolete response to thapsigargin
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1904579
name: obsolete cellular response to thapsigargin
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1904580
name: regulation of intracellular mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000]
synonym: "regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0008298 ! intracellular mRNA localization

[Term]
id: GO:1904581
name: negative regulation of intracellular mRNA localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000]
synonym: "down regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "down regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "down-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "down-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "downregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "downregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular mRNA localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular mRNA localization" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA localization, intracellular" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1904580 ! regulation of intracellular mRNA localization
relationship: negatively_regulates GO:0008298 ! intracellular mRNA localization

[Term]
id: GO:1904582
name: positive regulation of intracellular mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000]
synonym: "activation of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie]
synonym: "activation of intracellular mRNA localisation" NARROW [GOC:TermGenie]
synonym: "activation of intracellular mRNA localization" NARROW [GOC:TermGenie]
synonym: "activation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "activation of mRNA localization, intracellular" NARROW [GOC:TermGenie]
synonym: "activation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "up regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "up-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "up-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "upregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "upregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1904580 ! regulation of intracellular mRNA localization
relationship: positively_regulates GO:0008298 ! intracellular mRNA localization

[Term]
id: GO:1904583
name: response to polyamine macromolecule
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "response to polyamine" EXACT []
synonym: "response to polyamines" EXACT []
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904584
name: cellular response to polyamine macromolecule
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "cellular response to polyamine" EXACT []
synonym: "cellular response to polyamines" EXACT []
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904583 ! response to polyamine macromolecule

[Term]
id: GO:1904585
name: response to putrescine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "response to 1,4-Butanediamine" EXACT []
synonym: "response to 1,4-Diaminobutane" EXACT []
synonym: "response to tetramethylenediamine" EXACT []
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1904586
name: cellular response to putrescine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "cellular response to 1,4-Butanediamine" EXACT []
synonym: "cellular response to 1,4-Diaminobutane" EXACT []
synonym: "cellular response to tetramethylenediamine" EXACT []
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904585 ! response to putrescine

[Term]
id: GO:1904587
name: response to glycoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422]
synonym: "response to glycoproteins" EXACT []
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904588
name: cellular response to glycoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422]
synonym: "cellular response to glycoproteins" EXACT []
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904587 ! response to glycoprotein

[Term]
id: GO:1904589
name: regulation of protein import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629]
synonym: "regulation of protein uptake" EXACT [GOC:TermGenie]
is_a: GO:0051223 ! regulation of protein transport
relationship: regulates GO:0017038 ! protein import

[Term]
id: GO:1904590
name: negative regulation of protein import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629]
synonym: "down regulation of protein import" EXACT [GOC:TermGenie]
synonym: "down regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein import" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "downregulation of protein import" EXACT [GOC:TermGenie]
synonym: "downregulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "inhibition of protein import" NARROW [GOC:TermGenie]
synonym: "inhibition of protein uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein uptake" EXACT [GOC:TermGenie]
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1904589 ! regulation of protein import
relationship: negatively_regulates GO:0017038 ! protein import

[Term]
id: GO:1904591
name: positive regulation of protein import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629]
synonym: "activation of protein import" NARROW [GOC:TermGenie]
synonym: "activation of protein uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of protein import" EXACT [GOC:TermGenie]
synonym: "up regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein import" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of protein import" EXACT [GOC:TermGenie]
synonym: "upregulation of protein uptake" EXACT [GOC:TermGenie]
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1904589 ! regulation of protein import
relationship: positively_regulates GO:0017038 ! protein import

[Term]
id: GO:1904592
name: positive regulation of protein refolding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein refolding." [GO_REF:0000058, GOC:TermGenie, PMID:11360998]
synonym: "activation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "activation of protein refolding" NARROW [GOC:TermGenie]
synonym: "positive regulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "up regulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "up regulation of protein refolding" EXACT [GOC:TermGenie]
synonym: "up-regulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein refolding" EXACT [GOC:TermGenie]
synonym: "upregulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "upregulation of protein refolding" EXACT [GOC:TermGenie]
is_a: GO:0061083 ! regulation of protein refolding
is_a: GO:1903334 ! positive regulation of protein folding
relationship: positively_regulates GO:0042026 ! protein refolding

[Term]
id: GO:1904593
name: prostaglandin binding
namespace: molecular_function
def: "Binding to prostaglandin." [GO_REF:0000067, GOC:TermGenie, PMID:21445266]
is_a: GO:1901567 ! fatty acid derivative binding

[Term]
id: GO:1904594
name: regulation of termination of RNA polymerase II transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108]
synonym: "regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0031554 ! regulation of termination of DNA-templated transcription
relationship: regulates GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:1904595
name: positive regulation of termination of RNA polymerase II transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108]
synonym: "activation of RNA 3'-end formation by RNA polymerase II" NARROW [GOC:TermGenie]
synonym: "activation of RNA polymerase II transcription termination" NARROW [GOC:TermGenie]
synonym: "activation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "activation of termination of RNA polymerase II transcription" NARROW [GOC:TermGenie]
synonym: "activation of transcription termination from Pol II promoter" NARROW [GOC:TermGenie]
synonym: "activation of transcription termination from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "upregulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0060566 ! positive regulation of termination of DNA-templated transcription
is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription
relationship: positively_regulates GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:1904596
name: regulation of connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of wound healing connective tissue replacement, which may be replaced with fibrotic material, that occurs as part of an inflammatory response." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]
synonym: "regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:1905203 ! regulation of connective tissue replacement
relationship: regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing

[Term]
id: GO:1904597
name: negative regulation of connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of wound healing connective tissue replacement, which may be replaced with fibrotic material, that occurs as part of an inflammatory response." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]
synonym: "down regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "down regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "down regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "down-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "down-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "downregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "downregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "downregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "inhibition of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "inhibition of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie]
synonym: "inhibition of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "negative regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "negative regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing
is_a: GO:1905204 ! negative regulation of connective tissue replacement
relationship: negatively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing

[Term]
id: GO:1904598
name: positive regulation of connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of wound healing connective tissue replacement, which may be replaced with fibrotic material, that occurs as part of an inflammatory response." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]
synonym: "activation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "activation of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie]
synonym: "activation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "positive regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "positive regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "up regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "up regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "up regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "up-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "up-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "upregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "upregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "upregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing
is_a: GO:1905205 ! positive regulation of connective tissue replacement
relationship: positively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing

[Term]
id: GO:1904599
name: advanced glycation end-product binding
namespace: molecular_function
def: "Binding to advanced glycation end-product." [GO_REF:0000067, GOC:krc, GOC:TermGenie, PMID:1650387]
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:1904600
name: mating projection actin fusion focus assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus." [GO_REF:0000079, GOC:TermGenie, PMID:25825517]
synonym: "actin fusion focus assembly" BROAD []
synonym: "actin fusion focus formation" EXACT [GOC:TermGenie]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0030036 ! actin cytoskeleton organization
relationship: part_of GO:0031382 ! mating projection formation

[Term]
id: GO:1904601
name: protein transport to mating projection actin fusion focus
namespace: biological_process
def: "A process in which a protein is transported to a location within an actin fusion focus." [GO_REF:0000087, GOC:TermGenie, PMID:25825517]
synonym: "protein localisation in actin fusion focus" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin fusion focus" EXACT [GOC:TermGenie]
synonym: "protein localization in actin fusion focus" EXACT [GOC:TermGenie]
is_a: GO:0015031 ! protein transport

[Term]
id: GO:1904602
name: serotonin-activated cation-selective channel complex
namespace: cellular_component
def: "A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]
comment: An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay).
synonym: "5-HT-3 receptor complex" EXACT []
synonym: "5-HT3 receptor complex" EXACT []
synonym: "5-hydroxytryptamine receptor 3 complex" EXACT []
synonym: "5HT3 receptor complex" EXACT []
synonym: "serotonin receptor complex" BROAD []
is_a: GO:0034703 ! cation channel complex
is_a: GO:0098665 ! serotonin receptor complex
is_a: GO:0098878 ! neurotransmitter receptor complex

[Term]
id: GO:1904603
name: regulation of advanced glycation end-product receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]
subset: gocheck_obsoletion_candidate
synonym: "regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of RAGE activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of signaling receptor activity

[Term]
id: GO:1904604
name: negative regulation of advanced glycation end-product receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "downregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "inhibition of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of AGE receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of RAGE activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RAGE activity" EXACT [GOC:TermGenie]
is_a: GO:1904603 ! regulation of advanced glycation end-product receptor activity
is_a: GO:2000272 ! negative regulation of signaling receptor activity

[Term]
id: GO:1904605
name: obsolete positive regulation of advanced glycation end-product receptor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of AGE receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of RAGE activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "up regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "upregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RAGE activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904606
name: fat cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416]
synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:1904608
name: obsolete response to monosodium L-glutamate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115]
comment: This term was obsoleted because GCI patterns make it equivalent to response to L-glutamate; GO:1902065.
is_obsolete: true
replaced_by: GO:1902065

[Term]
id: GO:1904609
name: obsolete cellular response to monosodium L-glutamate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115]
comment: This term was obsoleted because GCI patterns make it equivalent to cellular response to L-glutamate; GO:1905232.
is_obsolete: true
consider: GO:1905232

[Term]
id: GO:1904610
name: response to 3,3',4,4',5-pentachlorobiphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "response to PCB 126" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1904611
name: cellular response to 3,3',4,4',5-pentachlorobiphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "cellular response to PCB 126" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904610 ! response to 3,3',4,4',5-pentachlorobiphenyl

[Term]
id: GO:1904612
name: response to 2,3,7,8-tetrachlorodibenzodioxine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "response to dioxin" EXACT []
synonym: "response to TCDD" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1904613
name: cellular response to 2,3,7,8-tetrachlorodibenzodioxine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "cellular response to dioxin" EXACT []
synonym: "cellular response to TCDD" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904612 ! response to 2,3,7,8-tetrachlorodibenzodioxine

[Term]
id: GO:1904614
name: response to biphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:1904615
name: cellular response to biphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904614 ! response to biphenyl

[Term]
id: GO:1904616
name: regulation of actin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
subset: gocheck_do_not_annotate
synonym: "regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:1904617
name: negative regulation of actin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
subset: gocheck_do_not_annotate
synonym: "down regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "down-regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "downregulation of actin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "inhibition of actin binding" NARROW [GOC:TermGenie]
synonym: "inhibition of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904616 ! regulation of actin binding

[Term]
id: GO:1904618
name: positive regulation of actin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
subset: gocheck_do_not_annotate
synonym: "activation of actin binding" NARROW [GOC:TermGenie]
synonym: "activation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "up regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "up-regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "upregulation of actin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904616 ! regulation of actin binding

[Term]
id: GO:1904619
name: response to dimethyl sulfoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812]
synonym: "response to DMSO" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1904620
name: cellular response to dimethyl sulfoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812]
synonym: "cellular response to DMSO" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904619 ! response to dimethyl sulfoxide

[Term]
id: GO:1904624
name: regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
relationship: regulates GO:0061537 ! glycine secretion, neurotransmission

[Term]
id: GO:1904625
name: negative regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
synonym: "down regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of glycine secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
relationship: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission

[Term]
id: GO:1904626
name: positive regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
synonym: "activation of glycine secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
relationship: positively_regulates GO:0061537 ! glycine secretion, neurotransmission

[Term]
id: GO:1904627
name: response to phorbol 13-acetate 12-myristate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903]
synonym: "response to phorbol 12-tetradecanoate 13-acetate" EXACT []
synonym: "response to PMA" EXACT []
synonym: "response to tetradecanoylphorbol acetate" EXACT []
synonym: "response to TPA" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1904628
name: cellular response to phorbol 13-acetate 12-myristate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903]
synonym: "cellular response to phorbol 12-tetradecanoate 13-acetate" EXACT []
synonym: "cellular response to response to PMA" EXACT []
synonym: "cellular response to tetradecanoylphorbol acetate" EXACT []
synonym: "cellular response to TPA" EXACT []
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904627 ! response to phorbol 13-acetate 12-myristate

[Term]
id: GO:1904629
name: response to diterpene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580]
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:1904630
name: cellular response to diterpene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1904629 ! response to diterpene

[Term]
id: GO:1904631
name: response to glucoside
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873]
synonym: "response to glucosides" EXACT []
is_a: GO:1903416 ! response to glycoside

[Term]
id: GO:1904632
name: cellular response to glucoside
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873]
synonym: "cellular response to glucosides" EXACT []
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904631 ! response to glucoside

[Term]
id: GO:1904633
name: regulation of podocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924]
synonym: "regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of glomerular visceral epithelial cell apoptotic process" EXACT []
synonym: "regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: regulates GO:1903210 ! podocyte apoptotic process

[Term]
id: GO:1904634
name: negative regulation of podocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924]
synonym: "down regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of glomerular visceral epithelial cell apoptotic process" EXACT []
synonym: "negative regulation of podocyte apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:1904633 ! regulation of podocyte apoptotic process
relationship: negatively_regulates GO:1903210 ! podocyte apoptotic process

[Term]
id: GO:1904635
name: positive regulation of podocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924]
synonym: "activation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of glomerular visceral epithelial cell apoptotic process" EXACT []
synonym: "positive regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:1904633 ! regulation of podocyte apoptotic process
relationship: positively_regulates GO:1903210 ! podocyte apoptotic process

[Term]
id: GO:1904636
name: response to ionomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:1904637
name: cellular response to ionomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904636 ! response to ionomycin

[Term]
id: GO:1904638
name: response to resveratrol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
is_a: GO:0035634 ! response to stilbenoid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904639
name: cellular response to resveratrol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904638 ! response to resveratrol

[Term]
id: GO:1904640
name: response to methionine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17716000]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904641
name: response to dinitrophenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883]
synonym: "response to dinitrophenols" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904642
name: cellular response to dinitrophenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883]
synonym: "cellular response to dinitrophenols" RELATED []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904641 ! response to dinitrophenol

[Term]
id: GO:1904643
name: response to curcumin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1904644
name: cellular response to curcumin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904643 ! response to curcumin

[Term]
id: GO:1904645
name: response to amyloid-beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
synonym: "response to beta-amyloid" EXACT []
synonym: "response to beta-amyloids" RELATED []
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904646
name: cellular response to amyloid-beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
synonym: "cellular response to beta-amyloid" EXACT []
synonym: "cellular response to beta-amyloids" RELATED []
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904645 ! response to amyloid-beta

[Term]
id: GO:1904647
name: response to rotenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1904648
name: cellular response to rotenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904647 ! response to rotenone

[Term]
id: GO:1904649
name: regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:1904606 ! fat cell apoptotic process

[Term]
id: GO:1904650
name: negative regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
relationship: negatively_regulates GO:1904606 ! fat cell apoptotic process

[Term]
id: GO:1904651
name: positive regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
relationship: positively_regulates GO:1904606 ! fat cell apoptotic process

[Term]
id: GO:1904652
name: protein localization to cell division site involved in cell separation after cytokinesis
namespace: biological_process
def: "Any protein localization to cell division site that is involved in cell separation after cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25411334]
is_a: GO:0072741 ! protein localization to cell division site
relationship: part_of GO:0000920 ! septum digestion after cytokinesis

[Term]
id: GO:1904653
name: regulation of lung alveolus development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064]
synonym: "regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "regulation of alveologenesis" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048286 ! lung alveolus development

[Term]
id: GO:1904654
name: negative regulation of lung alveolus development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064]
synonym: "down regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "down regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "down-regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "downregulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "inhibition of alveolarization" NARROW [GOC:TermGenie]
synonym: "inhibition of alveologenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of lung alveolus development" NARROW [GOC:TermGenie]
synonym: "negative regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of alveologenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904653 ! regulation of lung alveolus development
relationship: negatively_regulates GO:0048286 ! lung alveolus development

[Term]
id: GO:1904655
name: positive regulation of lung alveolus development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064]
synonym: "activation of alveolarization" NARROW [GOC:TermGenie]
synonym: "activation of alveologenesis" NARROW [GOC:TermGenie]
synonym: "activation of lung alveolus development" NARROW [GOC:TermGenie]
synonym: "positive regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "up-regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "upregulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lung alveolus development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904653 ! regulation of lung alveolus development
relationship: positively_regulates GO:0048286 ! lung alveolus development

[Term]
id: GO:1904656
name: regulation of sensory perception of sweet taste
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "regulation of sweet taste perception" EXACT [GOC:TermGenie]
is_a: GO:0051931 ! regulation of sensory perception
relationship: regulates GO:0050916 ! sensory perception of sweet taste

[Term]
id: GO:1904657
name: negative regulation of sensory perception of sweet taste
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "down regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "down regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "down-regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "downregulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "inhibition of sensory perception of sweet taste" NARROW [GOC:TermGenie]
synonym: "inhibition of sweet taste perception" NARROW [GOC:TermGenie]
synonym: "negative regulation of sweet taste perception" EXACT [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:1904656 ! regulation of sensory perception of sweet taste
relationship: negatively_regulates GO:0050916 ! sensory perception of sweet taste

[Term]
id: GO:1904658
name: positive regulation of sensory perception of sweet taste
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "activation of sensory perception of sweet taste" NARROW [GOC:TermGenie]
synonym: "activation of sweet taste perception" NARROW [GOC:TermGenie]
synonym: "positive regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "up regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "up-regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "upregulation of sweet taste perception" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:1904656 ! regulation of sensory perception of sweet taste
relationship: positively_regulates GO:0050916 ! sensory perception of sweet taste

[Term]
id: GO:1904659
name: D-glucose transmembrane transport
namespace: biological_process
alt_id: GO:0015758
def: "The process in which D-glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050]
synonym: "glucose transmembrane transport" EXACT []
synonym: "glucose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport

[Term]
id: GO:1904660
name: regulation of sensory perception of bitter taste
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "regulation of bitter taste perception" EXACT [GOC:TermGenie]
is_a: GO:0051931 ! regulation of sensory perception
relationship: regulates GO:0050913 ! sensory perception of bitter taste

[Term]
id: GO:1904661
name: negative regulation of sensory perception of bitter taste
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "down regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "down regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "down-regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "downregulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "inhibition of bitter taste perception" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory perception of bitter taste" NARROW [GOC:TermGenie]
synonym: "negative regulation of bitter taste perception" EXACT [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:1904660 ! regulation of sensory perception of bitter taste
relationship: negatively_regulates GO:0050913 ! sensory perception of bitter taste

[Term]
id: GO:1904662
name: positive regulation of sensory perception of bitter taste
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "activation of bitter taste perception" NARROW [GOC:TermGenie]
synonym: "activation of sensory perception of bitter taste" NARROW [GOC:TermGenie]
synonym: "positive regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "up regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "up-regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "upregulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:1904660 ! regulation of sensory perception of bitter taste
relationship: positively_regulates GO:0050913 ! sensory perception of bitter taste

[Term]
id: GO:1904663
name: regulation of N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799]
subset: gocheck_obsoletion_candidate
is_a: GO:1901983 ! regulation of protein acetylation
is_a: GO:1903317 ! regulation of protein maturation
relationship: regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation

[Term]
id: GO:1904664
name: negative regulation of N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799]
subset: gocheck_obsoletion_candidate
is_a: GO:1901984 ! negative regulation of protein acetylation
is_a: GO:1903318 ! negative regulation of protein maturation
is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation
relationship: negatively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation

[Term]
id: GO:1904665
name: positive regulation of N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799]
subset: gocheck_obsoletion_candidate
is_a: GO:1901985 ! positive regulation of protein acetylation
is_a: GO:1903319 ! positive regulation of protein maturation
is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation
relationship: positively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation

[Term]
id: GO:1904666
name: regulation of ubiquitin protein ligase activity
namespace: biological_process
alt_id: GO:1903834
def: "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]
subset: gocheck_obsoletion_candidate
synonym: "regulation of APC-fizzy related complex activity" NARROW []
synonym: "regulation of E3" RELATED [GOC:TermGenie]
synonym: "regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity

[Term]
id: GO:1904667
name: negative regulation of ubiquitin protein ligase activity
namespace: biological_process
alt_id: GO:0060564
alt_id: GO:1904190
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of E3" RELATED [GOC:TermGenie]
synonym: "down regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of E3" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of E3" RELATED [GOC:TermGenie]
synonym: "downregulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of E3" RELATED [GOC:TermGenie]
synonym: "inhibition of protein ubiquitination activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquitin ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquitin protein ligase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of anaphase-promoting complex activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of APC activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of APC-Cdc20 complex activity" NARROW []
synonym: "negative regulation of APC-fizzy related complex activity" NARROW []
synonym: "negative regulation of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of E3" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitotic anaphase-promoting complex activity" RELATED [GOC:vw]
synonym: "negative regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity
is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity

[Term]
id: GO:1904668
name: positive regulation of ubiquitin protein ligase activity
namespace: biological_process
alt_id: GO:0007092
alt_id: GO:0051488
alt_id: GO:0090623
alt_id: GO:1903835
def: "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]
subset: gocheck_obsoletion_candidate
synonym: "activation of anaphase-promoting complex activity" NARROW []
synonym: "activation of APC-Cdc20 complex activity" NARROW []
synonym: "activation of APC-fizzy related complex activity" NARROW []
synonym: "activation of E3" RELATED [GOC:TermGenie]
synonym: "activation of protein ubiquitination activity" NARROW [GOC:TermGenie]
synonym: "activation of ubiquitin ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of ubiquitin protein ligase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of APC-fizzy related complex activity" NARROW []
synonym: "positive regulation of E3" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquitin ligase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie]
synonym: "up regulation of E3" RELATED [GOC:TermGenie]
synonym: "up regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of E3" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie]
synonym: "upregulation of E3" RELATED [GOC:TermGenie]
synonym: "upregulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity
is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity

[Term]
id: GO:1904669
name: ATP export
namespace: biological_process
def: "The directed movement of ATP out of a cell or organelle." [GO_REF:0000074, GOC:TermGenie, PMID:24286344]
synonym: "ATP efflux" RELATED []
is_a: GO:0015867 ! ATP transport

[Term]
id: GO:1904670
name: obsolete actin filament polymerization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any actin filament polymerization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:TermGenie, PMID:24127216]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1904671
name: negative regulation of cell differentiation involved in stem cell population maintenance
namespace: biological_process
def: "Any negative regulation of cell differentiation that is involved in stem cell population maintenance." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "downregulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "inhibition of cell differentiation involved in stem cell population maintenance" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0019827 ! stem cell population maintenance

[Term]
id: GO:1904672
name: regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
is_a: GO:2000036 ! regulation of stem cell population maintenance
relationship: regulates GO:0035019 ! somatic stem cell population maintenance

[Term]
id: GO:1904673
name: negative regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of somatic stem cell population maintenance" NARROW [GOC:TermGenie]
is_a: GO:1902455 ! negative regulation of stem cell population maintenance
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
relationship: negatively_regulates GO:0035019 ! somatic stem cell population maintenance

[Term]
id: GO:1904674
name: positive regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "activation of somatic stem cell population maintenance" NARROW [GOC:TermGenie]
synonym: "up regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
is_a: GO:1902459 ! positive regulation of stem cell population maintenance
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
relationship: positively_regulates GO:0035019 ! somatic stem cell population maintenance

[Term]
id: GO:1904675
name: regulation of somatic stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:2000035 ! regulation of stem cell division
relationship: regulates GO:0048103 ! somatic stem cell division

[Term]
id: GO:1904676
name: negative regulation of somatic stem cell division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051782 ! negative regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
relationship: negatively_regulates GO:0048103 ! somatic stem cell division

[Term]
id: GO:1904677
name: positive regulation of somatic stem cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
relationship: positively_regulates GO:0048103 ! somatic stem cell division

[Term]
id: GO:1904678
name: alpha-aminoacyl-tRNA binding
namespace: molecular_function
def: "Binding to an alpha-aminoacyl-tRNA." [GO_REF:0000067, GOC:TermGenie, ISBN:155581073X]
synonym: "aminoacyl-tRNA binding" RELATED []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:1904679
name: myo-inositol import across plasma membrane
namespace: biological_process
alt_id: GO:0097357
def: "The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:9560432]
synonym: "myo-inositol import into cell" EXACT []
is_a: GO:0015791 ! polyol transmembrane transport
is_a: GO:0015798 ! myo-inositol transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:1904680
name: peptide transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015197
alt_id: GO:0015637
def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw]
synonym: "peptide transporter activity" RELATED []
synonym: "peptide uptake permease activity" RELATED []
xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:1904681
name: response to 3-methylcholanthrene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]
is_a: GO:1903165 ! response to polycyclic arene

[Term]
id: GO:1904682
name: cellular response to 3-methylcholanthrene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]
is_a: GO:1903166 ! cellular response to polycyclic arene
is_a: GO:1904681 ! response to 3-methylcholanthrene

[Term]
id: GO:1904683
name: regulation of metalloendopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]
subset: gocheck_obsoletion_candidate
synonym: "regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0052548 ! regulation of endopeptidase activity
is_a: GO:1905048 ! regulation of metallopeptidase activity

[Term]
id: GO:1904684
name: negative regulation of metalloendopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:1904683 ! regulation of metalloendopeptidase activity
is_a: GO:1905049 ! negative regulation of metallopeptidase activity

[Term]
id: GO:1904685
name: positive regulation of metalloendopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]
subset: gocheck_obsoletion_candidate
synonym: "activation of metalloendopeptidase activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:1904683 ! regulation of metalloendopeptidase activity
is_a: GO:1905050 ! positive regulation of metallopeptidase activity

[Term]
id: GO:1904686
name: regulation of mitotic spindle disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819]
synonym: "regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0060236 ! regulation of mitotic spindle organization
relationship: regulates GO:0051228 ! mitotic spindle disassembly

[Term]
id: GO:1904687
name: positive regulation of mitotic spindle disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819]
synonym: "activation of mitotic spindle breakdown" NARROW [GOC:TermGenie]
synonym: "activation of mitotic spindle catabolism" NARROW [GOC:TermGenie]
synonym: "activation of mitotic spindle degradation" NARROW [GOC:TermGenie]
synonym: "activation of mitotic spindle disassembly" NARROW [GOC:TermGenie]
synonym: "activation of spindle breakdown during mitosis" NARROW [GOC:TermGenie]
synonym: "activation of spindle degradation during mitosis" NARROW [GOC:TermGenie]
synonym: "activation of spindle disassembly during mitosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0110028 ! positive regulation of mitotic spindle organization
is_a: GO:1904686 ! regulation of mitotic spindle disassembly
relationship: positively_regulates GO:0051228 ! mitotic spindle disassembly

[Term]
id: GO:1904688
name: regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:2000765 ! regulation of cytoplasmic translation
relationship: regulates GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:1904689
name: negative regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
relationship: negatively_regulates GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:1904690
name: positive regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
relationship: positively_regulates GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:1904691
name: negative regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447]
synonym: "down regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of pancreatic B cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of pancreatic beta cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of type B pancreatic cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation
relationship: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation

[Term]
id: GO:1904692
name: positive regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447]
synonym: "activation of pancreatic B cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of pancreatic beta cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of type B pancreatic cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation
relationship: positively_regulates GO:0044342 ! type B pancreatic cell proliferation

[Term]
id: GO:1904693
name: midbrain morphogenesis
namespace: biological_process
def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "MB morphogenesis" BROAD [GOC:TermGenie]
synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030901 ! midbrain development
relationship: part_of GO:0048854 ! brain morphogenesis

[Term]
id: GO:1904694
name: negative regulation of vascular associated smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]
synonym: "down regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle contraction" EXACT []
is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
is_a: GO:0045906 ! negative regulation of vasoconstriction
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
relationship: negatively_regulates GO:0014829 ! vascular associated smooth muscle contraction

[Term]
id: GO:1904695
name: positive regulation of vascular associated smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]
synonym: "activation of vascular smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle contraction" EXACT []
synonym: "up regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
is_a: GO:0045907 ! positive regulation of vasoconstriction
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
relationship: positively_regulates GO:0014829 ! vascular associated smooth muscle contraction

[Term]
id: GO:1904697
name: regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:1990863 ! acinar cell proliferation

[Term]
id: GO:1904698
name: negative regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
relationship: negatively_regulates GO:1990863 ! acinar cell proliferation

[Term]
id: GO:1904699
name: positive regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
relationship: positively_regulates GO:1990863 ! acinar cell proliferation

[Term]
id: GO:1904700
name: granulosa cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a granulosa cell." [GO_REF:0000085, GOC:TermGenie, PMID:19208546]
synonym: "granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1904701
name: Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt-Frizzled-LRP5/6 complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11448771]
synonym: "Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "Wnt receptor complex assembly" BROAD [GOC:bf]
synonym: "WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904702
name: regulation of protein localization to adherens junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237]
synonym: "regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
is_a: GO:0150106 ! regulation of protein localization to cell-cell junction
relationship: regulates GO:0071896 ! protein localization to adherens junction

[Term]
id: GO:1904703
name: negative regulation of protein localization to adherens junction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237]
synonym: "down regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
is_a: GO:0150119 ! negative regulation of protein localization to cell-cell junction
is_a: GO:1904702 ! regulation of protein localization to adherens junction
relationship: negatively_regulates GO:0071896 ! protein localization to adherens junction

[Term]
id: GO:1904704
name: positive regulation of protein localization to adherens junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237]
synonym: "activation of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
is_a: GO:0150107 ! positive regulation of protein localization to cell-cell junction
is_a: GO:1904702 ! regulation of protein localization to adherens junction
relationship: positively_regulates GO:0071896 ! protein localization to adherens junction

[Term]
id: GO:1904705
name: regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
relationship: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation

[Term]
id: GO:1904706
name: negative regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
relationship: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation

[Term]
id: GO:1904707
name: positive regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
relationship: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation

[Term]
id: GO:1904708
name: regulation of granulosa cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546]
synonym: "regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: regulates GO:1904700 ! granulosa cell apoptotic process

[Term]
id: GO:1904709
name: negative regulation of granulosa cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546]
synonym: "down regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of granulosa cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:1904708 ! regulation of granulosa cell apoptotic process
relationship: negatively_regulates GO:1904700 ! granulosa cell apoptotic process

[Term]
id: GO:1904710
name: positive regulation of granulosa cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546]
synonym: "activation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of granulosa cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:1904708 ! regulation of granulosa cell apoptotic process
relationship: positively_regulates GO:1904700 ! granulosa cell apoptotic process

[Term]
id: GO:1904711
name: regulation of Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt receptor complex assembly" BROAD [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly

[Term]
id: GO:1904712
name: positive regulation of Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "positive regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly
relationship: positively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly

[Term]
id: GO:1904713
name: beta-catenin destruction complex binding
namespace: molecular_function
def: "Binding to a beta-catenin destruction complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650]
synonym: "23S APC complex binding" NARROW [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex binding" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex binding" EXACT [GOC:TermGenie]
synonym: "BDC binding" EXACT [PMID:22899650]
synonym: "beta-catenin degradation complex binding" EXACT [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1904714
name: regulation of chaperone-mediated autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]
synonym: "regulation of CMA" RELATED [GOC:TermGenie]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0061684 ! chaperone-mediated autophagy

[Term]
id: GO:1904715
name: negative regulation of chaperone-mediated autophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]
synonym: "down regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "down regulation of CMA" RELATED [GOC:TermGenie]
synonym: "down-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of CMA" RELATED [GOC:TermGenie]
synonym: "downregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of CMA" RELATED [GOC:TermGenie]
synonym: "inhibition of chaperone-mediated autophagy" NARROW [GOC:TermGenie]
synonym: "inhibition of CMA" RELATED [GOC:TermGenie]
synonym: "negative regulation of CMA" RELATED [GOC:TermGenie]
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1904714 ! regulation of chaperone-mediated autophagy
relationship: negatively_regulates GO:0061684 ! chaperone-mediated autophagy

[Term]
id: GO:1904716
name: positive regulation of chaperone-mediated autophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]
synonym: "activation of chaperone-mediated autophagy" NARROW [GOC:TermGenie]
synonym: "activation of CMA" RELATED [GOC:TermGenie]
synonym: "positive regulation of CMA" RELATED [GOC:TermGenie]
synonym: "up regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "up regulation of CMA" RELATED [GOC:TermGenie]
synonym: "up-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of CMA" RELATED [GOC:TermGenie]
synonym: "upregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of CMA" RELATED [GOC:TermGenie]
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:1904714 ! regulation of chaperone-mediated autophagy
relationship: positively_regulates GO:0061684 ! chaperone-mediated autophagy

[Term]
id: GO:1904717
name: regulation of AMPA glutamate receptor clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]
synonym: "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:0106104 ! regulation of glutamate receptor clustering
relationship: regulates GO:0097113 ! AMPA glutamate receptor clustering

[Term]
id: GO:1904718
name: negative regulation of AMPA glutamate receptor clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]
synonym: "down regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of AMPA receptor clustering" NARROW [GOC:TermGenie]
synonym: "negative regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "negative regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1901627 ! negative regulation of postsynaptic membrane organization
is_a: GO:1903910 ! negative regulation of receptor clustering
is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering
relationship: negatively_regulates GO:0097113 ! AMPA glutamate receptor clustering

[Term]
id: GO:1904719
name: positive regulation of AMPA glutamate receptor clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]
synonym: "activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "activation of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "activation of AMPA receptor clustering" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "positive regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1901628 ! positive regulation of postsynaptic membrane organization
is_a: GO:1903911 ! positive regulation of receptor clustering
is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering
relationship: positively_regulates GO:0097113 ! AMPA glutamate receptor clustering

[Term]
id: GO:1904720
name: obsolete regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063, PMID:20625543]
comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted.
synonym: "regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:1903895

[Term]
id: GO:1904721
name: obsolete negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063]
comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted.
synonym: "down regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "down regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:1903895

[Term]
id: GO:1904722
name: obsolete positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20625543]
comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted.
synonym: "activation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "activation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "activation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "activation of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:1903896

[Term]
id: GO:1904723
name: negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11433302]
synonym: "down regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "negative regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly
relationship: negatively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly

[Term]
id: GO:1904724
name: tertiary granule lumen
namespace: cellular_component
def: "Any membrane-enclosed lumen that is part of a tertiary granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]
synonym: "gelatinase granule membrane-enclosed lumen" RELATED []
synonym: "membrane-enclosed lumen of gelatinase granule" EXACT [GOC:TermGenie]
synonym: "membrane-enclosed lumen of tertiary granule" EXACT [GOC:TermGenie]
synonym: "tertiary granule membrane-enclosed lumen" EXACT []
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0070820 ! tertiary granule

[Term]
id: GO:1904725
name: obsolete TFIIB-class transcription factor binding involved in negative regulation of transcription
namespace: molecular_function
def: "OBSOLETE. Any TFIIB-class transcription factor binding that is involved in negative regulation of DNA-templated transcription." [GO_REF:0000061, GOC:rb, GOC:TermGenie, PMID:12461786]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "TFIIB-class transcription factor binding involved in down regulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in down regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in down-regulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in down-regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in downregulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in downregulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in inhibition of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in inhibition of transcription, DNA-dependent" NARROW [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of cellular transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-templated" EXACT []
synonym: "TFIIB-class transcription factor binding involved in transcription repressor activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904726
name: regulation of replicative senescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0090399 ! replicative senescence

[Term]
id: GO:1904727
name: negative regulation of replicative senescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]
synonym: "down regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "down-regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "downregulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "inhibition of replicative senescence" NARROW [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1904726 ! regulation of replicative senescence
relationship: negatively_regulates GO:0090399 ! replicative senescence

[Term]
id: GO:1904728
name: positive regulation of replicative senescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]
synonym: "activation of replicative senescence" NARROW [GOC:TermGenie]
synonym: "up regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "up-regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "upregulation of replicative senescence" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1904726 ! regulation of replicative senescence
relationship: positively_regulates GO:0090399 ! replicative senescence

[Term]
id: GO:1904729
name: regulation of intestinal lipid absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481]
is_a: GO:1904478 ! regulation of intestinal absorption
relationship: regulates GO:0098856 ! intestinal lipid absorption

[Term]
id: GO:1904730
name: negative regulation of intestinal lipid absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481]
synonym: "down regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "down-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "downregulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "inhibition of intestinal lipid absorption" NARROW [GOC:TermGenie]
is_a: GO:1904479 ! negative regulation of intestinal absorption
is_a: GO:1904729 ! regulation of intestinal lipid absorption
relationship: negatively_regulates GO:0098856 ! intestinal lipid absorption

[Term]
id: GO:1904731
name: positive regulation of intestinal lipid absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481]
synonym: "activation of intestinal lipid absorption" NARROW [GOC:TermGenie]
synonym: "up regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "up-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "upregulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
is_a: GO:1904480 ! positive regulation of intestinal absorption
is_a: GO:1904729 ! regulation of intestinal lipid absorption
relationship: positively_regulates GO:0098856 ! intestinal lipid absorption

[Term]
id: GO:1904732
name: regulation of electron transfer activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "regulation of azurin" NARROW [GOC:TermGenie]
synonym: "regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:1904733
name: negative regulation of electron transfer activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "down regulation of azurin" NARROW [GOC:TermGenie]
synonym: "down regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "down regulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "down regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "down regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "down regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "down-regulation of azurin" NARROW [GOC:TermGenie]
synonym: "down-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "down-regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "downregulation of azurin" NARROW [GOC:TermGenie]
synonym: "downregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "downregulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "downregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "downregulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of amicyanin" NARROW [GOC:TermGenie]
synonym: "inhibition of azurin" NARROW [GOC:TermGenie]
synonym: "inhibition of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of electron carrier activity" NARROW [GOC:TermGenie]
synonym: "inhibition of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "inhibition of electron donor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transporter activity" NARROW [GOC:TermGenie]
synonym: "inhibition of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of rubredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "negative regulation of azurin" NARROW [GOC:TermGenie]
synonym: "negative regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "negative regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:1904732 ! regulation of electron transfer activity

[Term]
id: GO:1904734
name: positive regulation of electron transfer activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781]
subset: gocheck_obsoletion_candidate
synonym: "activation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "activation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "activation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of amicyanin" NARROW [GOC:TermGenie]
synonym: "activation of azurin" NARROW [GOC:TermGenie]
synonym: "activation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "activation of electron carrier activity" NARROW [GOC:TermGenie]
synonym: "activation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "activation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "activation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "activation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "activation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "activation of electron transporter activity" NARROW [GOC:TermGenie]
synonym: "activation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "activation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "activation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "activation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "positive regulation of azurin" NARROW [GOC:TermGenie]
synonym: "positive regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "positive regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transporter activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "up regulation of azurin" NARROW [GOC:TermGenie]
synonym: "up regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of electron carrier activity" RELATED [GOC:TermGenie]
synonym: "up regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "up regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transporter activity" RELATED [GOC:TermGenie]
synonym: "up regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "up-regulation of azurin" NARROW [GOC:TermGenie]
synonym: "up-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron carrier activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "up-regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transporter activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "upregulation of azurin" NARROW [GOC:TermGenie]
synonym: "upregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "upregulation of electron carrier activity" RELATED [GOC:TermGenie]
synonym: "upregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "upregulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transporter activity" RELATED [GOC:TermGenie]
synonym: "upregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:1904732 ! regulation of electron transfer activity

[Term]
id: GO:1904735
name: regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781]
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
relationship: regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase

[Term]
id: GO:1904736
name: negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781]
synonym: "down regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "down-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "downregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "inhibition of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie]
is_a: GO:0031999 ! negative regulation of fatty acid beta-oxidation
is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
relationship: negatively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase

[Term]
id: GO:1904737
name: positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781]
synonym: "activation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie]
synonym: "up regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "up-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "upregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation
is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
relationship: positively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase

[Term]
id: GO:1904738
name: vascular associated smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "vascular smooth muscle cell migration" EXACT []
is_a: GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:1904739
name: obsolete regulation of synapse organization by posttranscriptional regulation of gene expression
namespace: biological_process
def: "OBSOLETE. A posttranscriptional regulation of gene expression that results in regulation of synapse organization." [GO_REF:0000063, GOC:rb, GOC:TermGenie, PMID:20729808]
comment: This term was obsoleted because it represents a precomposed term and should be represented as a GO-CAM model.
synonym: "regulation of synapse development by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie]
synonym: "regulation of synapse morphogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie]
synonym: "regulation of synapse organisation by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie]
synonym: "regulation of synapse organization and biogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904740
name: obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by general transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by RNA polymerase II transcription factor activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from Pol II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904741
name: obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904742
name: regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
subset: gocheck_do_not_annotate
synonym: "regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:1904743
name: negative regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
subset: gocheck_do_not_annotate
synonym: "down regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "inhibition of telomere binding" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric repeat binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1904742 ! regulation of telomeric DNA binding

[Term]
id: GO:1904744
name: positive regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
subset: gocheck_do_not_annotate
synonym: "activation of telomere binding" NARROW [GOC:TermGenie]
synonym: "activation of telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of telomeric repeat binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1904742 ! regulation of telomeric DNA binding

[Term]
id: GO:1904745
name: Atg1/ULK1 kinase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988]
synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904746
name: negative regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
relationship: negatively_regulates GO:1902742 ! apoptotic process involved in development

[Term]
id: GO:1904747
name: positive regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
relationship: positively_regulates GO:1902742 ! apoptotic process involved in development

[Term]
id: GO:1904748
name: regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: Q10943 in PMID:22801495, inferred from mutant phenotype
synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:1902742 ! apoptotic process involved in development

[Term]
id: GO:1904749
name: regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
relationship: regulates GO:1902570 ! protein localization to nucleolus

[Term]
id: GO:1904750
name: negative regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
relationship: negatively_regulates GO:1902570 ! protein localization to nucleolus

[Term]
id: GO:1904751
name: positive regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
relationship: positively_regulates GO:1902570 ! protein localization to nucleolus

[Term]
id: GO:1904752
name: regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
relationship: regulates GO:1904738 ! vascular associated smooth muscle cell migration

[Term]
id: GO:1904753
name: negative regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
relationship: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration

[Term]
id: GO:1904754
name: positive regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
relationship: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration

[Term]
id: GO:1904755
name: regulation of gut granule assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251]
synonym: "regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:1902900 ! gut granule assembly

[Term]
id: GO:1904756
name: negative regulation of gut granule assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251]
synonym: "down regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "downregulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "inhibition of gut granule assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of gut granule biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of gut granule formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1904755 ! regulation of gut granule assembly
relationship: negatively_regulates GO:1902900 ! gut granule assembly

[Term]
id: GO:1904757
name: positive regulation of gut granule assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251]
synonym: "activation of gut granule assembly" NARROW [GOC:TermGenie]
synonym: "activation of gut granule biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of gut granule formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "up regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "upregulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1904755 ! regulation of gut granule assembly
relationship: positively_regulates GO:1902900 ! gut granule assembly

[Term]
id: GO:1904758
name: protein localization to new growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a new growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:19431238]
synonym: "protein localisation in new growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to new growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in new growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization to new cell tip after activation of bipolar cell growth" EXACT []
synonym: "protein localization to new growing cell end" EXACT []
synonym: "protein localization to post-NETO new cell end" EXACT []
synonym: "protein localization to post-NETO new cell tip" EXACT []
synonym: "protein localization to post-new end take-off new cell tip" EXACT []
is_a: GO:1902486 ! protein localization to growing cell tip

[Term]
id: GO:1904759
name: protein localization to equatorial microtubule organizing center
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an equatorial microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:16611237]
synonym: "protein localisation in equatorial microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localisation to equatorial microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localization in equatorial microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localization to eMTOC" EXACT []
is_a: GO:0072741 ! protein localization to cell division site
is_a: GO:1905508 ! protein localization to microtubule organizing center

[Term]
id: GO:1904760
name: regulation of myofibroblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]
synonym: "regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0036446 ! myofibroblast differentiation

[Term]
id: GO:1904761
name: negative regulation of myofibroblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]
synonym: "down regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of myofibroblast cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1904760 ! regulation of myofibroblast differentiation
relationship: negatively_regulates GO:0036446 ! myofibroblast differentiation

[Term]
id: GO:1904762
name: positive regulation of myofibroblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]
synonym: "activation of myofibroblast cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1904760 ! regulation of myofibroblast differentiation
relationship: positively_regulates GO:0036446 ! myofibroblast differentiation

[Term]
id: GO:1904763
name: chaperone-mediated autophagy translocation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a chaperone-mediated autophagy translocation complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871]
synonym: "chaperone-mediated autophagy receptor complex assembly" RELATED [GOC:TermGenie]
synonym: "chaperone-mediated autophagy receptor complex formation" RELATED [GOC:TermGenie]
synonym: "chaperone-mediated autophagy translocation complex formation" EXACT [GOC:TermGenie]
synonym: "CMA receptor complex assembly" RELATED [GOC:TermGenie]
synonym: "CMA receptor complex formation" RELATED [GOC:TermGenie]
synonym: "CMA translocation complex assembly" EXACT [GOC:TermGenie]
synonym: "CMA translocation complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly
relationship: part_of GO:0061684 ! chaperone-mediated autophagy

[Term]
id: GO:1904764
name: chaperone-mediated autophagy translocation complex disassembly
namespace: biological_process
def: "The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871]
synonym: "chaperone-mediated autophagy receptor complex disassembly" RELATED [GOC:TermGenie]
synonym: "CMA receptor complex disassembly" RELATED [GOC:TermGenie]
synonym: "CMA translocation complex disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:1904765
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to maltose
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus." [GO_REF:0000060, GOC:TermGenie, PMID:24224056]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0045944

[Term]
id: GO:1904766
name: obsolete negative regulation of macroautophagy by TORC1 signaling
namespace: biological_process
def: "OBSOLETE. A TORC1 signaling that results in negative regulation of macroautophagy." [GO_REF:0000063, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:23602450]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of macroautophagy by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-specific autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-specific autophagy by TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of starvation-induced autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of starvation-induced autophagy by TORC1 signaling" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904767
name: octanoic acid binding
namespace: molecular_function
def: "Binding to octanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]
synonym: "caprylic acid binding" EXACT [CHEBI:28837]
is_a: GO:0005504 ! fatty acid binding

[Term]
id: GO:1904768
name: all-trans-retinol binding
namespace: molecular_function
def: "Binding to all-trans-retinol." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]
is_a: GO:0019841 ! retinol binding

[Term]
id: GO:1904769
name: isopentadecanoic acid binding
namespace: molecular_function
def: "Binding to isopentadecanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]
synonym: "13-methylmyristic acid binding" EXACT [CHEBI:39250]
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:1904770
name: intramembranous bone morphogenesis
namespace: biological_process
def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686]
synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie]
synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0060349 ! bone morphogenesis

[Term]
id: GO:1904771
name: obsolete cellular response to doxorubicin
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19801496]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1904772
name: response to tetrachloromethane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267]
synonym: "response to carbon tetrachloride" EXACT []
synonym: "response to CCL4" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1904773
name: obsolete cellular response to tetrachloromethane
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "cellular response to carbon tetrachloride" EXACT []
synonym: "cellular response to CCL4" EXACT []
is_obsolete: true

[Term]
id: GO:1904774
name: negative regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303]
synonym: "down regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of coenzyme Q biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
relationship: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:1904775
name: positive regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303]
synonym: "activation of coenzyme Q biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone anabolism" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone formation" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
relationship: positively_regulates GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:1904776
name: regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
relationship: regulates GO:0072697 ! protein localization to cell cortex

[Term]
id: GO:1904777
name: negative regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
relationship: negatively_regulates GO:0072697 ! protein localization to cell cortex

[Term]
id: GO:1904778
name: positive regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
relationship: positively_regulates GO:0072697 ! protein localization to cell cortex

[Term]
id: GO:1904779
name: regulation of protein localization to centrosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype).
synonym: "regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0071539 ! protein localization to centrosome

[Term]
id: GO:1904780
name: negative regulation of protein localization to centrosome
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype).
synonym: "down regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to centrosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to centrosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1904779 ! regulation of protein localization to centrosome
relationship: negatively_regulates GO:0071539 ! protein localization to centrosome

[Term]
id: GO:1904781
name: positive regulation of protein localization to centrosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype).
synonym: "activation of protein localisation to centrosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to centrosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to centrosome" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1904779 ! regulation of protein localization to centrosome
relationship: positively_regulates GO:0071539 ! protein localization to centrosome

[Term]
id: GO:1904782
name: negative regulation of NMDA glutamate receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "down-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "downregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "inhibition of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NMDA glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NMDA receptor" NARROW [GOC:TermGenie]
synonym: "negative regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NMDA receptor" EXACT [GOC:TermGenie]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:2000272 ! negative regulation of signaling receptor activity
is_a: GO:2000310 ! regulation of NMDA receptor activity

[Term]
id: GO:1904783
name: positive regulation of NMDA glutamate receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857]
subset: gocheck_obsoletion_candidate
synonym: "activation of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of NMDA glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of NMDA receptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "up regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "up-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "upregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NMDA receptor" EXACT [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:2000273 ! positive regulation of signaling receptor activity
is_a: GO:2000310 ! regulation of NMDA receptor activity

[Term]
id: GO:1904784
name: NLRP1 inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex." [GO_REF:0000079, GOC:TermGenie, PMID:19124602]
comment: The aggregation, arrangement and bonding together of a set of components to form the NLRP1 inflammasome complex, occurring at the level of an individual cell.
synonym: "NALP1 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "NALP1 inflammasome complex formation" EXACT [GOC:TermGenie]
synonym: "NLRP1 inflammasome complex formation" EXACT [GOC:TermGenie]
is_a: GO:0140632 ! canonical inflammasome complex assembly

[Term]
id: GO:1904785
name: regulation of asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329]
comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP)
synonym: "regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:1905933 ! regulation of cell fate determination
relationship: regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination

[Term]
id: GO:1904786
name: negative regulation of asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329]
comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP)
synonym: "down regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "inhibition of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "negative regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination
relationship: negatively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination

[Term]
id: GO:1904787
name: positive regulation of asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329]
comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP)
synonym: "activation of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "activation of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "activation of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "activation of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "activation of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie]
synonym: "positive regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "positive regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination
relationship: positively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination

[Term]
id: GO:1904788
name: obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:22144909]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of induction of conjugation with cellular fusion by global transcription regulation from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904789
name: obsolete regulation of mitotic actomyosin contractile ring maintenance
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring maintenance." [GO_REF:0000058, GOC:TermGenie, PMID:24115772]
comment: The reason for obsoletion is that this represents a phenotype.
synonym: "regulation of contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904790
name: regulation of shelterin complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]
synonym: "regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of telosome assembly" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0071573 ! shelterin complex assembly

[Term]
id: GO:1904791
name: negative regulation of shelterin complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]
synonym: "down regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of Pot1 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of shelterin complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of telosome assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of telosome assembly" EXACT []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1904790 ! regulation of shelterin complex assembly
relationship: negatively_regulates GO:0071573 ! shelterin complex assembly

[Term]
id: GO:1904792
name: positive regulation of shelterin complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]
synonym: "activation of Pot1 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of shelterin complex formation" NARROW [GOC:TermGenie]
synonym: "activation of telosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of telosome assembly" EXACT []
synonym: "up regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of telosome assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1904790 ! regulation of shelterin complex assembly
relationship: positively_regulates GO:0071573 ! shelterin complex assembly

[Term]
id: GO:1904793
name: regulation of euchromatin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
is_a: GO:0035561 ! regulation of chromatin binding

[Term]
id: GO:1904794
name: negative regulation of euchromatin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "down regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of euchromatin binding" NARROW [GOC:TermGenie]
is_a: GO:0035562 ! negative regulation of chromatin binding
is_a: GO:1904793 ! regulation of euchromatin binding

[Term]
id: GO:1904795
name: positive regulation of euchromatin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "activation of euchromatin binding" NARROW [GOC:TermGenie]
synonym: "up regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of euchromatin binding" EXACT [GOC:TermGenie]
is_a: GO:0035563 ! positive regulation of chromatin binding
is_a: GO:1904793 ! regulation of euchromatin binding

[Term]
id: GO:1904796
name: regulation of core promoter binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding

[Term]
id: GO:1904797
name: negative regulation of core promoter binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "down regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "downregulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "inhibition of core promoter binding" NARROW [GOC:TermGenie]
is_a: GO:1904796 ! regulation of core promoter binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding

[Term]
id: GO:1904798
name: positive regulation of core promoter binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "activation of core promoter binding" NARROW [GOC:TermGenie]
synonym: "up regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "upregulation of core promoter binding" EXACT [GOC:TermGenie]
is_a: GO:1904796 ! regulation of core promoter binding
is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding

[Term]
id: GO:1904799
name: regulation of neuron remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829]
comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype)
synonym: "regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "regulation of neuron remodelling" EXACT []
synonym: "regulation of neuronal remodeling" EXACT [GOC:TermGenie]
is_a: GO:0014041 ! regulation of neuron maturation
relationship: regulates GO:0016322 ! neuron remodeling

[Term]
id: GO:1904800
name: negative regulation of neuron remodeling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829]
comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype)
synonym: "down regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "down regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "down-regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "down-regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "downregulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "downregulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "inhibition of axon pruning" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron remodeling" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal remodeling" NARROW [GOC:TermGenie]
synonym: "negative regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuron remodelling" EXACT []
synonym: "negative regulation of neuronal remodeling" EXACT [GOC:TermGenie]
is_a: GO:0014043 ! negative regulation of neuron maturation
is_a: GO:1904799 ! regulation of neuron remodeling
relationship: negatively_regulates GO:0016322 ! neuron remodeling

[Term]
id: GO:1904801
name: positive regulation of neuron remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829]
comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype)
synonym: "activation of axon pruning" NARROW [GOC:TermGenie]
synonym: "activation of neuron remodeling" NARROW [GOC:TermGenie]
synonym: "activation of neuronal remodeling" NARROW [GOC:TermGenie]
synonym: "positive regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuron remodelling" EXACT []
synonym: "positive regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "up regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "up regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "up regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "up-regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "up-regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "upregulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "upregulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal remodeling" EXACT [GOC:TermGenie]
is_a: GO:0014042 ! positive regulation of neuron maturation
is_a: GO:1904799 ! regulation of neuron remodeling
relationship: positively_regulates GO:0016322 ! neuron remodeling

[Term]
id: GO:1904802
name: RITS complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a RITS complex." [GO_REF:0000079, GOC:TermGenie, PMID:26443059]
synonym: "RITS complex formation" EXACT [GOC:TermGenie]
is_a: GO:0022618 ! protein-RNA complex assembly

[Term]
id: GO:1904803
name: regulation of translation involved in cellular response to UV
namespace: biological_process
def: "Any regulation of translation that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:17369398]
synonym: "regulation of protein anabolism involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of protein biosynthesis involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of protein formation involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of protein synthesis involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie]
is_a: GO:0006417 ! regulation of translation
relationship: part_of GO:0034644 ! cellular response to UV

[Term]
id: GO:1904806
name: regulation of protein oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0018158 ! protein oxidation

[Term]
id: GO:1904807
name: negative regulation of protein oxidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein amino acid oxidation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein oxidation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1904806 ! regulation of protein oxidation
relationship: negatively_regulates GO:0018158 ! protein oxidation

[Term]
id: GO:1904808
name: positive regulation of protein oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein amino acid oxidation" NARROW [GOC:TermGenie]
synonym: "activation of protein oxidation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein oxidation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1904806 ! regulation of protein oxidation
relationship: positively_regulates GO:0018158 ! protein oxidation

[Term]
id: GO:1904809
name: regulation of dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:1901950 ! dense core granule transport

[Term]
id: GO:1904810
name: negative regulation of dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie]
synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1904809 ! regulation of dense core granule transport
relationship: negatively_regulates GO:1901950 ! dense core granule transport

[Term]
id: GO:1904811
name: positive regulation of dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie]
synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1904809 ! regulation of dense core granule transport
relationship: positively_regulates GO:1901950 ! dense core granule transport

[Term]
id: GO:1904812
name: rRNA acetylation involved in maturation of SSU-rRNA
namespace: biological_process
def: "Any rRNA acetylation that is involved in maturation of SSU-rRNA." [GO_REF:0000060, GOC:TermGenie, PMID:25402480]
synonym: "rRNA acetylation involved in processing of 20S pre-rRNA" NARROW [GOC:TermGenie]
synonym: "rRNA acetylation involved in SSU-rRNA maturation" EXACT [GOC:TermGenie]
is_a: GO:1990882 ! rRNA acetylation
relationship: part_of GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:1904813
name: ficolin-1-rich granule lumen
namespace: cellular_component
def: "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]
synonym: "ficolin-1-rich granule membrane-enclosed lumen" EXACT []
synonym: "membrane-enclosed lumen of ficolin granule" RELATED [GOC:TermGenie]
synonym: "membrane-enclosed lumen of ficolin-1 rich granule" EXACT [GOC:TermGenie]
synonym: "membrane-enclosed lumen of ficolin-1-rich granule" EXACT [GOC:TermGenie]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0101002 ! ficolin-1-rich granule

[Term]
id: GO:1904814
name: regulation of protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]
synonym: "regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0070198 ! protein localization to chromosome, telomeric region

[Term]
id: GO:1904815
name: negative regulation of protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]
synonym: "down regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region
relationship: negatively_regulates GO:0070198 ! protein localization to chromosome, telomeric region

[Term]
id: GO:1904816
name: positive regulation of protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]
synonym: "activation of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region
relationship: positively_regulates GO:0070198 ! protein localization to chromosome, telomeric region

[Term]
id: GO:1904817
name: serous membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "serosa development" RELATED [GOC:TermGenie]
synonym: "tunica serosa development" EXACT [GOC:TermGenie]
synonym: "wall of serous sac development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1904818
name: visceral peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:1904820 ! peritoneum development

[Term]
id: GO:1904819
name: parietal peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:1904820 ! peritoneum development

[Term]
id: GO:1904820
name: peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritonaeum development" RELATED [GOC:TermGenie]
is_a: GO:1904817 ! serous membrane development

[Term]
id: GO:1904821
name: chloroplast disassembly
namespace: biological_process
def: "The disaggregation of a chloroplast into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:26494759]
comment: The disaggregation of a chloroplast into its constituent components.
synonym: "chloroplast degradation" RELATED [PMID:26494759]
is_a: GO:0009658 ! chloroplast organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:1904823
name: purine nucleobase transmembrane transport
namespace: biological_process
def: "The process in which a purine nucleobase is transported across a membrane." [GO_REF:0000069, GOC:TermGenie]
is_a: GO:0006863 ! purine nucleobase transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport

[Term]
id: GO:1904824
name: anaphase-promoting complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex." [GO_REF:0000079, GOC:TermGenie, PMID:16950791]
synonym: "anaphase promoting complex assembly" EXACT [GOC:TermGenie]
synonym: "anaphase promoting complex formation" EXACT [GOC:TermGenie]
synonym: "anaphase-promoting complex formation" EXACT [GOC:TermGenie]
synonym: "APC assembly" BROAD []
synonym: "cyclosome assembly" EXACT [GOC:TermGenie]
synonym: "cyclosome formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904825
name: protein localization to microtubule plus-end
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:24039245]
synonym: "protein localisation to microtubule plus-end" EXACT [GOC:TermGenie]
is_a: GO:1905725 ! protein localization to microtubule end

[Term]
id: GO:1904826
name: regulation of hydrogen sulfide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0070814 ! hydrogen sulfide biosynthetic process

[Term]
id: GO:1904827
name: negative regulation of hydrogen sulfide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "down regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide formation" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process
relationship: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process

[Term]
id: GO:1904828
name: positive regulation of hydrogen sulfide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "activation of hydrogen sulfide anabolism" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide formation" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide synthesis" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process
relationship: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process

[Term]
id: GO:1904829
name: regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
relationship: regulates GO:0035887 ! aortic smooth muscle cell differentiation

[Term]
id: GO:1904830
name: negative regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
relationship: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation

[Term]
id: GO:1904831
name: positive regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
relationship: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation

[Term]
id: GO:1904832
name: negative regulation of removal of superoxide radicals
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756]
synonym: "down regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "down regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "down regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "down regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "down-regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "down-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "down-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "downregulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "downregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "downregulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "inhibition of removal of O2-" NARROW [GOC:TermGenie]
synonym: "inhibition of removal of oxygen free radicals" NARROW [GOC:TermGenie]
synonym: "inhibition of removal of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "negative regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "negative regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
is_a: GO:1900408 ! negative regulation of cellular response to oxidative stress
is_a: GO:1901032 ! negative regulation of response to reactive oxygen species
is_a: GO:2000121 ! regulation of removal of superoxide radicals
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
relationship: negatively_regulates GO:0019430 ! removal of superoxide radicals

[Term]
id: GO:1904833
name: positive regulation of removal of superoxide radicals
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756]
synonym: "activation of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "activation of removal of O2-" NARROW [GOC:TermGenie]
synonym: "activation of removal of oxygen free radicals" NARROW [GOC:TermGenie]
synonym: "activation of removal of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "positive regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "positive regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "up regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "up regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "up regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "up-regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "up-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "up-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "upregulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "upregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "upregulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
is_a: GO:2000121 ! regulation of removal of superoxide radicals
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
relationship: positively_regulates GO:0019430 ! removal of superoxide radicals

[Term]
id: GO:1904835
name: dorsal root ganglion morphogenesis
namespace: biological_process
def: "The developmental process by which a dorsal root ganglion is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]
synonym: "dorsal root ganglia morphogenesis" RELATED [GOC:TermGenie]
synonym: "DRG morphogenesis" RELATED [GOC:TermGenie]
synonym: "ganglion of dorsal root morphogenesis" EXACT [GOC:TermGenie]
synonym: "ganglion sensorium nervi spinalis morphogenesis" RELATED [GOC:TermGenie]
synonym: "ganglion spinale morphogenesis" RELATED [GOC:TermGenie]
synonym: "ganglion spinalis morphogenesis" EXACT [GOC:TermGenie]
synonym: "posterior root ganglion morphogenesis" RELATED [GOC:TermGenie]
synonym: "spinal ganglion morphogenesis" EXACT [GOC:TermGenie]
synonym: "spinal ganglion part of peripheral nervous system morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0061552 ! ganglion morphogenesis
relationship: part_of GO:1990791 ! dorsal root ganglion development

[Term]
id: GO:1904836
name: facioacoustic ganglion morphogenesis
namespace: biological_process
def: "The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized." [GO_REF:0000083, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]
synonym: "acoustico-facial VII-VIII ganglion complex morphogenesis" EXACT [UBERON:0012175]
synonym: "acousticofacial ganglion morphogenesis" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion complex morphogenesis" RELATED [GOC:TermGenie]
synonym: "facio-acoustic ganglion complex VII-VIII morphogenesis" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion morphogenesis" EXACT [GOC:TermGenie]
synonym: "facio-acoustic VII-VIII ganglion complex morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0061559 ! cranial ganglion morphogenesis
relationship: part_of GO:1903375 ! facioacoustic ganglion development

[Term]
id: GO:1904837
name: beta-catenin-TCF complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]
synonym: "beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904838
name: regulation of male germ-line stem cell asymmetric division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709]
synonym: "regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000035 ! regulation of stem cell division
relationship: regulates GO:0048133 ! male germ-line stem cell asymmetric division

[Term]
id: GO:1904839
name: negative regulation of male germ-line stem cell asymmetric division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709]
synonym: "down regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "down regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "down-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "down-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "downregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "downregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "inhibition of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie]
synonym: "inhibition of male germ-line stem cell renewal" NARROW [GOC:TermGenie]
synonym: "negative regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045769 ! negative regulation of asymmetric cell division
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division
relationship: negatively_regulates GO:0048133 ! male germ-line stem cell asymmetric division

[Term]
id: GO:1904840
name: positive regulation of male germ-line stem cell asymmetric division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709]
synonym: "activation of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie]
synonym: "activation of male germ-line stem cell renewal" NARROW [GOC:TermGenie]
synonym: "positive regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "up regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "up-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "upregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "upregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0045770 ! positive regulation of asymmetric cell division
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division
relationship: positively_regulates GO:0048133 ! male germ-line stem cell asymmetric division

[Term]
id: GO:1904841
name: TORC2 complex binding
namespace: molecular_function
def: "Binding to a TORC2 complex." [GOC:TermGenie, PMID:20660630]
comment: Binding to a TORC2 complex, a protein complex that mediates the phosphorylation of protein kinase B
synonym: "mTORC2 binding" NARROW [GOC:TermGenie]
synonym: "rapamycin and nutrient-insensitive TOR complex binding" EXACT [GOC:TermGenie]
synonym: "TOR complex 2 binding" EXACT [GOC:TermGenie]
synonym: "TORC 2 complex binding" EXACT [GOC:TermGenie]
synonym: "TORC2 binding" EXACT [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1904842
name: response to nitroglycerin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975]
synonym: "response to nitroglycerine" EXACT []
synonym: "response to nitroglycerol" EXACT []
synonym: "response to trinitroglycerin" EXACT []
synonym: "response to trinitroglycerol" EXACT []
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904843
name: cellular response to nitroglycerin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975]
synonym: "cellular response to nitroglycerine" EXACT []
synonym: "cellular response to nitroglycerol" EXACT []
synonym: "cellular response to trinitroglycerin" EXACT []
synonym: "cellular response to trinitroglycerol" EXACT []
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904842 ! response to nitroglycerin

[Term]
id: GO:1904844
name: response to L-glutamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904845
name: cellular response to L-glutamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904844 ! response to L-glutamine

[Term]
id: GO:1904846
name: negative regulation of establishment of bipolar cell polarity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of bipolar cell polarity." [GO_REF:0000058, GOC:TermGenie, PMID:26525038]
synonym: "down regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of bipolar cell polarity" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity
relationship: negatively_regulates GO:0061171 ! establishment of bipolar cell polarity

[Term]
id: GO:1904847
name: regulation of cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor

[Term]
id: GO:1904848
name: negative regulation of cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]
synonym: "down regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "downregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "inhibition of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor
relationship: negatively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor

[Term]
id: GO:1904849
name: positive regulation of cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]
synonym: "activation of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie]
synonym: "up regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "upregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor
relationship: positively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor

[Term]
id: GO:1904850
name: negative regulation of establishment of protein localization to telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "down regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation to telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
is_a: GO:0070203 ! regulation of establishment of protein localization to telomere
is_a: GO:1904815 ! negative regulation of protein localization to chromosome, telomeric region
is_a: GO:1904950 ! negative regulation of establishment of protein localization
relationship: negatively_regulates GO:0070200 ! establishment of protein localization to telomere

[Term]
id: GO:1904851
name: positive regulation of establishment of protein localization to telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "activation of establishment of protein localisation to telomere" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:0070203 ! regulation of establishment of protein localization to telomere
is_a: GO:1904816 ! positive regulation of protein localization to chromosome, telomeric region
is_a: GO:1904951 ! positive regulation of establishment of protein localization
relationship: positively_regulates GO:0070200 ! establishment of protein localization to telomere

[Term]
id: GO:1904852
name: trimethylamine-N-oxide reductase (cytochrome c) complex
namespace: cellular_component
def: "A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11056172]
comment: An example of this is TorA in E. coli (UniProt ID P33225) in PMID:11056172 (inferred from direct assay).
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1904853
name: protein localization to ascospore wall
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an ascospore wall." [GO_REF:0000087, GOC:TermGenie, PMID:24623719]
synonym: "protein localisation in ascospore wall" EXACT [GOC:TermGenie]
synonym: "protein localisation to ascospore wall" EXACT [GOC:TermGenie]
synonym: "protein localization in ascospore wall" EXACT [GOC:TermGenie]
is_a: GO:0099614 ! protein localization to spore cell wall

[Term]
id: GO:1904854
name: proteasome core complex binding
namespace: molecular_function
def: "Binding to a proteasome core complex." [GOC:TermGenie, PMID:16096059]
synonym: "20S core complex binding" NARROW [GOC:TermGenie]
synonym: "20S proteasome binding" NARROW [GOC:TermGenie]
synonym: "macropain binding" EXACT [GOC:TermGenie]
synonym: "PA28gamma-20S proteasome binding" NARROW [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1904855
name: proteasome regulatory particle binding
namespace: molecular_function
def: "Binding to a proteasome regulatory particle." [GOC:TermGenie, PMID:16096059]
synonym: "19S regulatory particle binding" NARROW [GOC:TermGenie]
synonym: "modulator complex binding" RELATED [GOC:TermGenie]
synonym: "PA700 proteasome activator binding" NARROW [GOC:TermGenie]
synonym: "PA700-dependent proteasome activator binding" EXACT [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1904856
name: cytolytic granule lumen
namespace: cellular_component
def: "Any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule." [GO_REF:0000064, GOC:TermGenie, PMID:17272266, PMID:21247065]
synonym: "cytolytic granule cytoplasmic membrane-bounded vesicle lumen" EXACT []
synonym: "cytoplasmic membrane-bounded vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie]
synonym: "cytoplasmic membrane-enclosed vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie]
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0060205 ! cytoplasmic vesicle lumen
relationship: part_of GO:0044194 ! cytolytic granule

[Term]
id: GO:1904857
name: regulation of endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus
relationship: regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor

[Term]
id: GO:1904858
name: negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]
synonym: "down regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus
is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor
relationship: negatively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor

[Term]
id: GO:1904859
name: positive regulation of endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]
synonym: "activation of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor
relationship: positively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor

[Term]
id: GO:1904860
name: DNA synthesis involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA biosynthetic process that is involved in mitotic DNA replication." [GO_REF:0000060, GOC:TermGenie, PMID:16849602]
synonym: "DNA anabolism involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA anabolism involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in mitotic DNA replication" EXACT []
synonym: "DNA biosynthetic process involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA formation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA formation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA synthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA synthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0090592 ! DNA synthesis involved in DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1904861
name: excitatory synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302]
synonym: "excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0007416 ! synapse assembly

[Term]
id: GO:1904862
name: inhibitory synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "inhibitory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0007416 ! synapse assembly

[Term]
id: GO:1904863
name: regulation of beta-catenin-TCF complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1904837 ! beta-catenin-TCF complex assembly

[Term]
id: GO:1904864
name: negative regulation of beta-catenin-TCF complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]
synonym: "down regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "down regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly
relationship: negatively_regulates GO:1904837 ! beta-catenin-TCF complex assembly

[Term]
id: GO:1904865
name: positive regulation of beta-catenin-TCF complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "activation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly
relationship: positively_regulates GO:1904837 ! beta-catenin-TCF complex assembly

[Term]
id: GO:1904866
name: ventral tegmental area development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26548362]
synonym: "a10a development" EXACT [GOC:TermGenie]
synonym: "area tegmentalis ventralis (Tsai) development" RELATED [GOC:TermGenie]
synonym: "area tegmentalis ventralis development" RELATED [GOC:TermGenie]
synonym: "tegmentum ventrale development" RELATED [GOC:TermGenie]
synonym: "ventral brain stem development" RELATED [GOC:TermGenie]
synonym: "ventral tegmental area (Tsai) development" RELATED [GOC:TermGenie]
synonym: "ventral tegmental area of tsai development" EXACT [GOC:TermGenie]
synonym: "ventral tegmental nucleus (Rioch) development" RELATED [GOC:TermGenie]
synonym: "ventral tegmental nucleus (tsai) development" EXACT [GOC:TermGenie]
synonym: "ventral tegmental nucleus of tsai development" EXACT [GOC:TermGenie]
synonym: "ventral tegmentum development" EXACT [Wikipedia:Ventral_tegmental_area]
synonym: "ventromedial mesencephalic tegmentum development" RELATED [GOC:TermGenie]
synonym: "VTA development" BROAD [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:1904867
name: protein localization to Cajal body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "protein localization in Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1903405 ! protein localization to nuclear body

[Term]
id: GO:1904868
name: telomerase catalytic core complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex." [GO_REF:0000079, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:1905323 ! telomerase holoenzyme complex assembly

[Term]
id: GO:1904869
name: regulation of protein localization to Cajal body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
relationship: regulates GO:1904867 ! protein localization to Cajal body

[Term]
id: GO:1904870
name: negative regulation of protein localization to Cajal body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "down regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in Cajal body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to Cajal body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in Cajal body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to Cajal body" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
is_a: GO:1904869 ! regulation of protein localization to Cajal body
relationship: negatively_regulates GO:1904867 ! protein localization to Cajal body

[Term]
id: GO:1904871
name: positive regulation of protein localization to Cajal body
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "activation of protein localisation in Cajal body" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to Cajal body" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in Cajal body" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to Cajal body" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
is_a: GO:1904869 ! regulation of protein localization to Cajal body
relationship: positively_regulates GO:1904867 ! protein localization to Cajal body

[Term]
id: GO:1904872
name: regulation of telomerase RNA localization to Cajal body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0090671 ! telomerase RNA localization to Cajal body

[Term]
id: GO:1904873
name: negative regulation of telomerase RNA localization to Cajal body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "down regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "inhibition of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body
relationship: negatively_regulates GO:0090671 ! telomerase RNA localization to Cajal body

[Term]
id: GO:1904874
name: positive regulation of telomerase RNA localization to Cajal body
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "activation of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie]
synonym: "up regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body
relationship: positively_regulates GO:0090671 ! telomerase RNA localization to Cajal body

[Term]
id: GO:1904875
name: regulation of DNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]
subset: gocheck_obsoletion_candidate
is_a: GO:0051105 ! regulation of DNA ligation
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:1904876
name: obsolete negative regulation of DNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA ligase activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904877
name: positive regulation of DNA ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]
subset: gocheck_obsoletion_candidate
synonym: "activation of DNA ligase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051106 ! positive regulation of DNA ligation
is_a: GO:0051351 ! positive regulation of ligase activity
is_a: GO:1904875 ! regulation of DNA ligase activity

[Term]
id: GO:1904878
name: negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515]
synonym: "down regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of L-type calcium current" NARROW [GOC:TermGenie]
synonym: "negative regulation of generation of L-type calcium current" RELATED []
is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
relationship: negatively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel

[Term]
id: GO:1904879
name: positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515]
synonym: "activation of generation of L-type calcium current" NARROW [GOC:TermGenie]
synonym: "positive regulation of generation of L-type calcium current" RELATED []
synonym: "up regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
relationship: positively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel

[Term]
id: GO:1904880
name: response to hydrogen sulfide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591]
synonym: "response to dihydridosulfur" EXACT []
synonym: "response to sulfane" EXACT []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1904881
name: cellular response to hydrogen sulfide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591]
synonym: "cellular response to dihydridosulfur" EXACT []
synonym: "cellular response to sulfane" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904880 ! response to hydrogen sulfide

[Term]
id: GO:1904882
name: regulation of telomerase catalytic core complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1904868 ! telomerase catalytic core complex assembly

[Term]
id: GO:1904883
name: negative regulation of telomerase catalytic core complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "down regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of telomerase catalytic core complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly
relationship: negatively_regulates GO:1904868 ! telomerase catalytic core complex assembly

[Term]
id: GO:1904884
name: positive regulation of telomerase catalytic core complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "activation of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of telomerase catalytic core complex formation" NARROW [GOC:TermGenie]
synonym: "activation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly
relationship: positively_regulates GO:1904868 ! telomerase catalytic core complex assembly

[Term]
id: GO:1904885
name: beta-catenin destruction complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin destruction complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17143292, PMID:23169527]
synonym: "23S APC complex assembly" NARROW [GOC:TermGenie]
synonym: "23S APC complex formation" NARROW [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex assembly" EXACT [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex formation" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex assembly" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex formation" EXACT [GOC:TermGenie]
synonym: "BDC assembly" EXACT [GOC:TermGenie]
synonym: "BDC formation" EXACT [GOC:TermGenie]
synonym: "beta-catenin degradation complex assembly" EXACT [GOC:TermGenie]
synonym: "beta-catenin degradation complex formation" EXACT [GOC:TermGenie]
synonym: "beta-catenin destruction complex formation" EXACT [GOC:TermGenie]
synonym: "destruction complex formation" RELATED [PMID:23169527]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904886
name: beta-catenin destruction complex disassembly
namespace: biological_process
def: "The disaggregation of a beta-catenin destruction complex into its constituent components." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23169527]
synonym: "23S APC complex disassembly" NARROW [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex disassembly" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex disassembly" EXACT [GOC:TermGenie]
synonym: "BDC disassembly" EXACT [GOC:TermGenie]
synonym: "beta-catenin degradation complex disassembly" EXACT [GOC:TermGenie]
synonym: "dissociation of beta-catenin degradation complex" EXACT [GOC:bf, PMID:17318175]
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: part_of GO:0060070 ! canonical Wnt signaling pathway

[Term]
id: GO:1904887
name: Wnt signalosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt signalosome." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650]
synonym: "LRP5/6 signalosome assembly" EXACT [GOC:TermGenie]
synonym: "LRP5/6 signalosome formation" EXACT [GOC:TermGenie]
synonym: "LRP6 signalosome assembly" NARROW [GOC:TermGenie]
synonym: "LRP6 signalosome formation" NARROW [GOC:TermGenie]
synonym: "Wnt signalosome complex assembly" EXACT [GOC:TermGenie]
synonym: "Wnt signalosome complex formation" EXACT [GOC:TermGenie]
synonym: "Wnt signalosome formation" EXACT [GOC:TermGenie]
synonym: "Wnt-LRP5/6 signalosome assembly" EXACT [GOC:TermGenie]
synonym: "Wnt-LRP5/6 signalosome formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904888
name: cranial skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227]
synonym: "cranial skeleton development" NARROW [GOC:TermGenie]
synonym: "craniofacial development" NARROW [PMID:11262227]
synonym: "cranium development" RELATED [GOC:TermGenie]
synonym: "osteocranium development" NARROW [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1904889
name: regulation of excitatory synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
relationship: regulates GO:1904861 ! excitatory synapse assembly

[Term]
id: GO:1904890
name: negative regulation of excitatory synapse assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "downregulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "inhibition of excitatory synapse assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of excitatory synapse formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1904889 ! regulation of excitatory synapse assembly
relationship: negatively_regulates GO:1904861 ! excitatory synapse assembly

[Term]
id: GO:1904891
name: positive regulation of excitatory synapse assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302]
synonym: "activation of excitatory synapse assembly" NARROW [GOC:TermGenie]
synonym: "activation of excitatory synapse formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "up regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "upregulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051965 ! positive regulation of synapse assembly
is_a: GO:1904889 ! regulation of excitatory synapse assembly
relationship: positively_regulates GO:1904861 ! excitatory synapse assembly

[Term]
id: GO:1904892
name: regulation of receptor signaling pathway via STAT
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor signaling via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]
synonym: "regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0097696 ! cell surface receptor signaling pathway via STAT

[Term]
id: GO:1904893
name: negative regulation of receptor signaling pathway via STAT
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor signaling via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]
synonym: "down regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of kinase activated-STAT cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of kinase-STAT cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of STAT cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of STAT signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT
relationship: negatively_regulates GO:0097696 ! cell surface receptor signaling pathway via STAT

[Term]
id: GO:1904894
name: positive regulation of receptor signaling pathway via STAT
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]
synonym: "activation of kinase activated-STAT cascade" NARROW [GOC:TermGenie]
synonym: "activation of kinase-STAT cascade" NARROW [GOC:TermGenie]
synonym: "activation of STAT cascade" NARROW [GOC:TermGenie]
synonym: "activation of STAT signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of STAT signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT
relationship: positively_regulates GO:0097696 ! cell surface receptor signaling pathway via STAT

[Term]
id: GO:1904895
name: ESCRT complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109]
synonym: "endosomal sorting complex required for transport assembly" EXACT [GOC:TermGenie]
synonym: "endosomal sorting complex required for transport formation" EXACT [GOC:TermGenie]
synonym: "ESCRT complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1904896
name: ESCRT complex disassembly
namespace: biological_process
def: "The disaggregation of an ESCRT complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109]
synonym: "endosomal sorting complex required for transport disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:1904897
name: regulation of hepatic stellate cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192]
synonym: "regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048145 ! regulation of fibroblast proliferation
relationship: regulates GO:1990922 ! hepatic stellate cell proliferation

[Term]
id: GO:1904898
name: negative regulation of hepatic stellate cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192]
synonym: "down regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatic stellate cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of Ito cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048147 ! negative regulation of fibroblast proliferation
is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation
relationship: negatively_regulates GO:1990922 ! hepatic stellate cell proliferation

[Term]
id: GO:1904899
name: positive regulation of hepatic stellate cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192]
synonym: "activation of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hepatic stellate cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of Ito cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048146 ! positive regulation of fibroblast proliferation
is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation
relationship: positively_regulates GO:1990922 ! hepatic stellate cell proliferation

[Term]
id: GO:1904900
name: negative regulation of myosin II filament organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "down regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "down regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "down regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "down-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "downregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "downregulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "downregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "inhibition of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "inhibition of myosin II filament organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of myosin II filament organization" NARROW [GOC:TermGenie]
synonym: "inhibition of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "negative regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
is_a: GO:0043519 ! regulation of myosin II filament organization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
relationship: negatively_regulates GO:0031038 ! myosin II filament organization

[Term]
id: GO:1904901
name: positive regulation of myosin II filament organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "activation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "activation of myosin II filament organisation" NARROW [GOC:TermGenie]
synonym: "activation of myosin II filament organization" NARROW [GOC:TermGenie]
synonym: "activation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "positive regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "up regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "up regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "up regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "up-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "upregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "upregulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "upregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
is_a: GO:0043519 ! regulation of myosin II filament organization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
relationship: positively_regulates GO:0031038 ! myosin II filament organization

[Term]
id: GO:1904902
name: ESCRT III complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT III complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296]
synonym: "ESCRT III complex formation" EXACT [GOC:TermGenie]
is_a: GO:1904895 ! ESCRT complex assembly

[Term]
id: GO:1904903
name: ESCRT III complex disassembly
namespace: biological_process
def: "The disaggregation of an ESCRT III complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296]
is_a: GO:1904896 ! ESCRT complex disassembly

[Term]
id: GO:1904904
name: regulation of endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]
is_a: GO:0001952 ! regulation of cell-matrix adhesion
relationship: regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin

[Term]
id: GO:1904905
name: negative regulation of endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]
synonym: "down regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie]
is_a: GO:0001953 ! negative regulation of cell-matrix adhesion
is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin
relationship: negatively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin

[Term]
id: GO:1904906
name: positive regulation of endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]
synonym: "activation of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
is_a: GO:0001954 ! positive regulation of cell-matrix adhesion
is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin
relationship: positively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin

[Term]
id: GO:1904907
name: regulation of maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]
synonym: "regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
relationship: regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric

[Term]
id: GO:1904908
name: negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]
synonym: "down regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "inhibition of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie]
synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric
relationship: negatively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric

[Term]
id: GO:1904909
name: positive regulation of maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]
synonym: "activation of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie]
synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric
relationship: positively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric

[Term]
id: GO:1904910
name: regulation of establishment of RNA localization to telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0097694 ! establishment of RNA localization to telomere

[Term]
id: GO:1904911
name: negative regulation of establishment of RNA localization to telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "down regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of RNA localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere
relationship: negatively_regulates GO:0097694 ! establishment of RNA localization to telomere

[Term]
id: GO:1904912
name: positive regulation of establishment of RNA localization to telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "activation of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie]
synonym: "activation of establishment of RNA localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere
relationship: positively_regulates GO:0097694 ! establishment of RNA localization to telomere

[Term]
id: GO:1904913
name: regulation of establishment of protein-containing complex localization to telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of macromolecular complex localization to telomere" RELATED []
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0097695 ! establishment of protein-containing complex localization to telomere

[Term]
id: GO:1904914
name: negative regulation of establishment of protein-containing complex localization to telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "down regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of macromolecular complex localization to telomere" RELATED []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904913 ! regulation of establishment of protein-containing complex localization to telomere
relationship: negatively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere

[Term]
id: GO:1904915
name: positive regulation of establishment of protein-containing complex localization to telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "activation of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie]
synonym: "activation of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of macromolecular complex localization to telomere" RELATED []
synonym: "up regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904913 ! regulation of establishment of protein-containing complex localization to telomere
relationship: positively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere

[Term]
id: GO:1904916
name: transmembrane L-lysine transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-lysine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0089707 ! L-lysine transmembrane export from vacuole

[Term]
id: GO:1904917
name: L-arginine transmembrane transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-arginine across a membrane from lysosomal lumen to cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
synonym: "transmembrane L-arginine transport from lysosomal lumen to cytosol" EXACT []
is_a: GO:0007041 ! lysosomal transport
is_a: GO:1990818 ! L-arginine transmembrane export from vacuole

[Term]
id: GO:1904918
name: transmembrane L-histidine transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-histidine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:0089709 ! L-histidine transmembrane transport

[Term]
id: GO:1904919
name: transmembrane L-cystine transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-cystine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0015811 ! L-cystine transport
is_a: GO:0034489 ! neutral amino acid transmembrane export from vacuole
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1904920
name: obsolete regulation of MAPK cascade involved in axon regeneration
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904921
name: obsolete negative regulation of MAPK cascade involved in axon regeneration
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "downregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "downregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "downregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "downregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "inhibition of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "inhibition of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "negative regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "negative regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "negative regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "negative regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "negative regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904922
name: obsolete positive regulation of MAPK cascade involved in axon regeneration
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "activation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "activation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "positive regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "positive regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "positive regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "positive regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "positive regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "upregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "upregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "upregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "upregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904923
name: obsolete regulation of autophagy of mitochondrion in response to mitochondrial depolarization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of autophagy of mitochondrion in response to mitochondrial depolarization." [PMID:22020285]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
is_obsolete: true
replaced_by: GO:1905089

[Term]
id: GO:1904924
name: obsolete negative regulation of mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [PMID:22020285]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
is_obsolete: true
replaced_by: GO:1905090

[Term]
id: GO:1904925
name: obsolete positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of autophagy of the mitochondrion in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using\nGO:1905091 positive regulation of type 2 mitophagy
is_obsolete: true
replaced_by: GO:1905091

[Term]
id: GO:1904926
name: response to palmitoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:1904927
name: cellular response to palmitoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:1904926 ! response to palmitoleic acid

[Term]
id: GO:1904928
name: obsolete coreceptor activity involved in canonical Wnt signaling pathway
namespace: molecular_function
def: "OBSOLETE. Any coreceptor activity that is involved in a canonical Wnt signaling pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
comment: Precomposed term that should be captured as GO-CAMs or extension.
synonym: "coreceptor activity involved in canonical Wnt receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in canonical Wnt-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in frizzled-1 receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "Wnt co-receptor activity, canonical signaling" EXACT [GOC:bf]
synonym: "Wnt co-receptor, canonical pathway" EXACT [GOC:bf]
is_obsolete: true

[Term]
id: GO:1904929
name: obsolete coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
namespace: molecular_function
def: "OBSOLETE. Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
comment: Precomposed term that should be captured as GO-CAMs or extension.
synonym: "coreceptor activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor activity involved in PCP pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie]
synonym: "Wnt co-receptor activity, non-canonical signaling" BROAD [GOC:bf]
synonym: "Wnt co-receptor, non-canonical pathway" BROAD [GOC:bf]
synonym: "Wnt/PCP co-receptor activity" EXACT [PMID:24431302]
is_obsolete: true

[Term]
id: GO:1904930
name: amphisome membrane
namespace: cellular_component
def: "Any membrane that is part of an amphisome." [GO_REF:0000064, GOC:bhm, GOC:TermGenie, PMID:17984323]
is_a: GO:0000421 ! autophagosome membrane
relationship: part_of GO:0044753 ! amphisome

[Term]
id: GO:1904931
name: MCM complex binding
namespace: molecular_function
def: "Binding to an MCM complex." [GOC:TermGenie, PMID:12604790]
synonym: "mini-chromosome maintenance complex binding" EXACT [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1904932
name: negative regulation of cartilage condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cartilage condensation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17604018]
synonym: "down regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "inhibition of cartilage condensation" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1902026 ! regulation of cartilage condensation
relationship: negatively_regulates GO:0001502 ! cartilage condensation

[Term]
id: GO:1904933
name: regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
relationship: regulates GO:0033278 ! cell proliferation in midbrain

[Term]
id: GO:1904934
name: negative regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
relationship: negatively_regulates GO:0033278 ! cell proliferation in midbrain

[Term]
id: GO:1904935
name: positive regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
relationship: positively_regulates GO:0033278 ! cell proliferation in midbrain

[Term]
id: GO:1904936
name: interneuron migration
namespace: biological_process
def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
synonym: "inter neuron migration" EXACT [GOC:ah]
synonym: "inter-neuron migration" EXACT [GOC:ah]
is_a: GO:0001764 ! neuron migration

[Term]
id: GO:1904937
name: sensory neuron migration
namespace: biological_process
def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
is_a: GO:0001764 ! neuron migration

[Term]
id: GO:1904938
name: obsolete planar cell polarity pathway involved in axon guidance
namespace: biological_process
def: "OBSOLETE. Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21106844, PMID:23517308]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "non-canonical Wnt signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
synonym: "PCP pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "PCP pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "PCP pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:bf]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling involved in axon guidance" EXACT [GOC:bf]
synonym: "Wnt-PCP signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0007411
consider: GO:0060071

[Term]
id: GO:1904939
name: obsolete regulation of DNA nucleotidylexotransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of TdT" RELATED [GOC:TermGenie]
synonym: "regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of terminal transferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904940
name: obsolete negative regulation of DNA nucleotidylexotransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TdT" RELATED [GOC:TermGenie]
synonym: "down regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "down regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TdT" RELATED [GOC:TermGenie]
synonym: "down-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of addase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TdT" RELATED [GOC:TermGenie]
synonym: "downregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "downregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of addase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TdT" RELATED [GOC:TermGenie]
synonym: "inhibition of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "inhibition of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TdT" RELATED [GOC:TermGenie]
synonym: "negative regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal transferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904941
name: obsolete positive regulation of DNA nucleotidylexotransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of addase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of TdT" RELATED [GOC:TermGenie]
synonym: "activation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "activation of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of TdT" RELATED [GOC:TermGenie]
synonym: "positive regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of TdT" RELATED [GOC:TermGenie]
synonym: "up regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of TdT" RELATED [GOC:TermGenie]
synonym: "up-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of addase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of TdT" RELATED [GOC:TermGenie]
synonym: "upregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "upregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal transferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904942
name: regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
is_a: GO:1901210 ! regulation of cardiac chamber formation
relationship: regulates GO:0003211 ! cardiac ventricle formation

[Term]
id: GO:1904943
name: negative regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie]
is_a: GO:1901211 ! negative regulation of cardiac chamber formation
is_a: GO:1904413 ! negative regulation of cardiac ventricle development
is_a: GO:1904942 ! regulation of cardiac ventricle formation
relationship: negatively_regulates GO:0003211 ! cardiac ventricle formation

[Term]
id: GO:1904944
name: positive regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
is_a: GO:1901212 ! positive regulation of cardiac chamber formation
is_a: GO:1904942 ! regulation of cardiac ventricle formation
relationship: positively_regulates GO:0003211 ! cardiac ventricle formation

[Term]
id: GO:1904945
name: obsolete response to cobalt(II) acetate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1904946
name: obsolete cellular response to cobalt(II) acetate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1904947
name: folate import into mitochondrion
namespace: biological_process
def: "The process in which folic acid is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890]
synonym: "folic acid import into mitochondrion" RELATED []
is_a: GO:0098838 ! folate transmembrane transport
is_a: GO:0170036 ! import into the mitochondrion

[Term]
id: GO:1904948
name: midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron." [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665]
synonym: "DA neurogenesis from midbrain floor plate" EXACT [PMID:19122665]
synonym: "mDA neuron differentiation" EXACT [PMID:24287202]
synonym: "midbrain DA neurogenesis" EXACT [PMID:19122665]
synonym: "midbrain dopaminergic neuron production" EXACT [PMID:19122665]
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0071542 ! dopaminergic neuron differentiation
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:1904949
name: ATPase complex
namespace: cellular_component
def: "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181]
comment: An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay).
synonym: "VPS4 complex" NARROW []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1904950
name: negative regulation of establishment of protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
is_a: GO:1903828 ! negative regulation of protein localization
relationship: negatively_regulates GO:0045184 ! establishment of protein localization

[Term]
id: GO:1904951
name: positive regulation of establishment of protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "activation of protein positioning" NARROW [GOC:TermGenie]
synonym: "activation of protein recruitment" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
is_a: GO:1903829 ! positive regulation of protein localization
relationship: positively_regulates GO:0045184 ! establishment of protein localization

[Term]
id: GO:1904952
name: hydroxycinnamic acid transport
namespace: biological_process
def: "The directed movement of a hydroxycinnamic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26744218]
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:1904953
name: obsolete Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250, PMID:22988876, PMID:23517308]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "Wnt-mediated midbrain DA neuron differentiation" EXACT [PMID:23517308]
is_obsolete: true
consider: GO:0016055
consider: GO:1904948

[Term]
id: GO:1904954
name: obsolete canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:bf]
synonym: "frizzled-1 receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0060070
consider: GO:1904948

[Term]
id: GO:1904955
name: obsolete planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any Wnt signaling pathway, planar cell polarity pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in mDA neuron differentiation" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt-mediated midbrain DA neuron differentiation" BROAD [GOC:bf]
synonym: "PCP pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT []
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0060071
consider: GO:1904948

[Term]
id: GO:1904956
name: regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
relationship: regulates GO:1904948 ! midbrain dopaminergic neuron differentiation

[Term]
id: GO:1904957
name: negative regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "inhibition of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "negative regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904339 ! negative regulation of dopaminergic neuron differentiation
is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation
relationship: negatively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation

[Term]
id: GO:1904958
name: positive regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "activation of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "positive regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904340 ! positive regulation of dopaminergic neuron differentiation
is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation
relationship: positively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation

[Term]
id: GO:1904959
name: regulation of cytochrome-c oxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017]
subset: gocheck_obsoletion_candidate
synonym: "regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0051341 ! regulation of oxidoreductase activity
is_a: GO:1904732 ! regulation of electron transfer activity

[Term]
id: GO:1904960
name: positive regulation of cytochrome-c oxidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017]
subset: gocheck_obsoletion_candidate
synonym: "activation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "activation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "activation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "activation of cytochrome c oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "activation of cytochrome-c oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "activation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "activation of indophenolase" NARROW [GOC:TermGenie]
synonym: "activation of NADH cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "positive regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "positive regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "positive regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "up regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "up regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "up regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "up regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "up-regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "up-regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "up-regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "upregulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "upregulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "upregulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "upregulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "upregulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1904734 ! positive regulation of electron transfer activity
is_a: GO:1904959 ! regulation of cytochrome-c oxidase activity

[Term]
id: GO:1904961
name: quiescent center organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the quiescent center. This process pertains to the physical shaping of a rudimentary structure." [GO_REF:0000084, GOC:TermGenie, PMID:21233333]
synonym: "quiescent center structural organization" EXACT []
is_a: GO:0048532 ! anatomical structure arrangement

[Term]
id: GO:1904962
name: plastid to vacuole vesicle-mediated transport
namespace: biological_process
def: "The vesicle-mediated and directed movement of substances from plastid to vacuole." [GO_REF:0000076, GOC:TermGenie, PMID:25281689]
synonym: "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport" RELATED [GOC:TermGenie]
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport

[Term]
id: GO:1904963
name: regulation of phytol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650]
synonym: "regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "regulation of phytol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0033520 ! phytol biosynthetic process

[Term]
id: GO:1904964
name: positive regulation of phytol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650]
synonym: "activation of phytol anabolism" NARROW [GOC:TermGenie]
synonym: "activation of phytol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of phytol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of phytol formation" NARROW [GOC:TermGenie]
synonym: "activation of phytol synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of phytol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
is_a: GO:1904963 ! regulation of phytol biosynthetic process
relationship: positively_regulates GO:0033520 ! phytol biosynthetic process

[Term]
id: GO:1904965
name: regulation of vitamin E biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244]
synonym: "regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
relationship: regulates GO:0010189 ! vitamin E biosynthetic process

[Term]
id: GO:1904966
name: positive regulation of vitamin E biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244]
synonym: "activation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E anabolism" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E formation" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:1904965 ! regulation of vitamin E biosynthetic process
relationship: positively_regulates GO:0010189 ! vitamin E biosynthetic process

[Term]
id: GO:1904967
name: regulation of spindle attachment to meiosis I kinetochore
namespace: biological_process
alt_id: GO:0090699
def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:21920317, PMID:23770679]
synonym: "correction of merotelic kinetochore attachment, meiosis I" RELATED []
synonym: "regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT []
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
synonym: "repair of merotelic kinetochore attachment defect, meiosis I" RELATED []
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect
is_a: GO:1903046 ! meiotic cell cycle process
is_a: GO:2000241 ! regulation of reproductive process
relationship: part_of GO:0043060 ! meiotic metaphase I homologous chromosome alignment
relationship: regulates GO:0051455 ! spindle attachment to meiosis I kinetochore

[Term]
id: GO:1904968
name: positive regulation of spindle attachment to meiosis I kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679]
synonym: "activation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" NARROW [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in meiosis I" NARROW [GOC:TermGenie]
synonym: "activation of monopolar attachment" NARROW [GOC:TermGenie]
synonym: "activation of sister kinetochore mono-orientation" NARROW [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT []
synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "positive regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "positive regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "up regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "up regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "up-regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "up-regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "upregulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "upregulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore
is_a: GO:1904967 ! regulation of spindle attachment to meiosis I kinetochore
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0051455 ! spindle attachment to meiosis I kinetochore

[Term]
id: GO:1904969
name: slow muscle cell migration
namespace: biological_process
def: "The orderly movement of a slow muscle cell from one site to another." [GO_REF:0000091, GOC:TermGenie, GOC:ymb, PMID:14667409, PMID:15572133, PMID:25534553]
comment: The directional migration of a slow muscle cell from one site to another within the embryo.
synonym: "slow-twitch muscle cell migration" EXACT [PMID:14667409]
is_a: GO:0110122 ! myotube cell migration

[Term]
id: GO:1904970
name: brush border assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border." [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409]
synonym: "brush border formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:1904971
name: regulation of viral translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]
synonym: "regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein synthesis" EXACT [GOC:TermGenie]
is_a: GO:0050792 ! regulation of viral process
relationship: regulates GO:0019081 ! viral translation

[Term]
id: GO:1904972
name: negative regulation of viral translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]
synonym: "down regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of viral translation" EXACT [GOC:TermGenie]
synonym: "inhibition of viral protein anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein formation" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of viral translation" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein synthesis" EXACT [GOC:TermGenie]
is_a: GO:0048525 ! negative regulation of viral process
is_a: GO:1904971 ! regulation of viral translation
relationship: negatively_regulates GO:0019081 ! viral translation

[Term]
id: GO:1904973
name: positive regulation of viral translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]
synonym: "activation of viral protein anabolism" NARROW [GOC:TermGenie]
synonym: "activation of viral protein biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of viral protein biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of viral protein formation" NARROW [GOC:TermGenie]
synonym: "activation of viral protein synthesis" NARROW [GOC:TermGenie]
synonym: "activation of viral translation" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of viral translation" EXACT [GOC:TermGenie]
is_a: GO:0048524 ! positive regulation of viral process
is_a: GO:1904971 ! regulation of viral translation
relationship: positively_regulates GO:0019081 ! viral translation

[Term]
id: GO:1904974
name: heparanase complex
namespace: cellular_component
def: "A protein complex which is capable of heparanase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12927802]
comment: An example of this is HPSE in human (Q9Y251) in PMID:12927802 (inferred from direct assay).
synonym: "HEPS complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1904975
name: response to bleomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1904976
name: cellular response to bleomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904975 ! response to bleomycin

[Term]
id: GO:1904977
name: lymphatic endothelial cell migration
namespace: biological_process
def: "The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel." [GO_REF:0000091, GOC:TermGenie, PMID:25745057]
is_a: GO:0043542 ! endothelial cell migration
relationship: part_of GO:0036303 ! lymph vessel morphogenesis

[Term]
id: GO:1904978
name: regulation of endosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]
synonym: "regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007032 ! endosome organization

[Term]
id: GO:1904979
name: negative regulation of endosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]
synonym: "down regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "down regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "downregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of endosome organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of endosome organization" NARROW [GOC:TermGenie]
synonym: "inhibition of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1904978 ! regulation of endosome organization
relationship: negatively_regulates GO:0007032 ! endosome organization

[Term]
id: GO:1904980
name: positive regulation of endosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]
synonym: "activation of endosome organisation" NARROW [GOC:TermGenie]
synonym: "activation of endosome organization" NARROW [GOC:TermGenie]
synonym: "activation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "up regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "upregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1904978 ! regulation of endosome organization
relationship: positively_regulates GO:0007032 ! endosome organization

[Term]
id: GO:1904981
name: maltose transmembrane transport
namespace: biological_process
def: "The process in which maltose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464]
is_a: GO:0015768 ! maltose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:1904982
name: sucrose transmembrane transport
namespace: biological_process
def: "The process in which sucrose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464]
is_a: GO:0015770 ! sucrose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:1904983
name: glycine import into mitochondrion
namespace: biological_process
def: "The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]
synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT []
is_a: GO:0015816 ! glycine transport
is_a: GO:0170036 ! import into the mitochondrion
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1904984
name: regulation of quinolinate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0019805 ! quinolinate biosynthetic process

[Term]
id: GO:1904985
name: negative regulation of quinolinate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "down regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of quinolinate anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate formation" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1904984 ! regulation of quinolinate biosynthetic process
relationship: negatively_regulates GO:0019805 ! quinolinate biosynthetic process

[Term]
id: GO:1904986
name: positive regulation of quinolinate biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of quinolinate anabolism" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate formation" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1904984 ! regulation of quinolinate biosynthetic process
relationship: positively_regulates GO:0019805 ! quinolinate biosynthetic process

[Term]
id: GO:1904987
name: regulation of endothelial cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0042118 ! endothelial cell activation

[Term]
id: GO:1904988
name: negative regulation of endothelial cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie]
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
relationship: negatively_regulates GO:0042118 ! endothelial cell activation

[Term]
id: GO:1904989
name: positive regulation of endothelial cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie]
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
relationship: positively_regulates GO:0042118 ! endothelial cell activation

[Term]
id: GO:1904990
name: regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]
synonym: "regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
relationship: regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway

[Term]
id: GO:1904991
name: negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]
synonym: "down regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway
is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
relationship: negatively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway

[Term]
id: GO:1904992
name: positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]
synonym: "activation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "activation of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0060161 ! positive regulation of dopamine receptor signaling pathway
is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
relationship: positively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway

[Term]
id: GO:1904993
name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in positive regulation of G2/M transition of mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie, PMID:24728197]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie]
synonym: "positive regulation of CDK activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDK activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1904994
name: regulation of leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
relationship: regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell

[Term]
id: GO:1904995
name: negative regulation of leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]
synonym: "down regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie]
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
relationship: negatively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell

[Term]
id: GO:1904996
name: positive regulation of leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]
synonym: "activation of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
relationship: positively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell

[Term]
id: GO:1904997
name: regulation of leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
relationship: regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell

[Term]
id: GO:1904998
name: negative regulation of leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]
synonym: "down regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie]
is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell
is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell
relationship: negatively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell

[Term]
id: GO:1904999
name: positive regulation of leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]
synonym: "activation of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell
is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell
relationship: positively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell

[Term]
id: GO:1905000
name: regulation of membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]
synonym: "regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
is_a: GO:0060372 ! regulation of atrial cardiac muscle cell membrane repolarization
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
relationship: regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential

[Term]
id: GO:1905001
name: negative regulation of membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]
synonym: "down regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "down regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "down regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "down-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "down-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "downregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "downregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "inhibition of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "inhibition of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "negative regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential
is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential
relationship: negatively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential

[Term]
id: GO:1905002
name: positive regulation of membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]
synonym: "activation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "activation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "activation of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "positive regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "up regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "up regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "up regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "up-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "up-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "upregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "upregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential
is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential
relationship: positively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential

[Term]
id: GO:1905003
name: picolinic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]
synonym: "picolinate metabolism" EXACT [CHEBI:38184]
synonym: "picolinic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:1905004
name: picolinic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]
synonym: "picolinate biosynthesis" EXACT [CHEBI:38184]
synonym: "picolinate biosynthetic process" EXACT [CHEBI:38184]
synonym: "picolinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "picolinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "picolinic acid formation" EXACT [GOC:TermGenie]
synonym: "picolinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1905003 ! picolinic acid metabolic process

[Term]
id: GO:1905005
name: regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition
relationship: regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation

[Term]
id: GO:1905006
name: negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "down regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie]
is_a: GO:0062044 ! negative regulation of cardiac epithelial to mesenchymal transition
is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
relationship: negatively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation

[Term]
id: GO:1905007
name: positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "activation of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
is_a: GO:0062043 ! positive regulation of cardiac epithelial to mesenchymal transition
is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
relationship: positively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation

[Term]
id: GO:1905008
name: regulation of L-lysine import across plasma membrane
namespace: biological_process
alt_id: GO:0010805
def: "Any process that modulates the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219]
synonym: "regulation of L-lysine import into cell" EXACT []
synonym: "regulation of lysine import" BROAD []
synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:0097639 ! L-lysine import across plasma membrane

[Term]
id: GO:1905009
name: negative regulation of L-lysine import across plasma membrane
namespace: biological_process
alt_id: GO:0010806
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219]
synonym: "down regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of L-lysine import into cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-lysine import into cell" EXACT []
synonym: "negative regulation of lysine import" BROAD []
synonym: "negative regulation of lysine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane
relationship: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane

[Term]
id: GO:1905010
name: positive regulation of L-lysine import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219]
synonym: "activation of L-lysine import into cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-lysine import into cell" EXACT []
synonym: "up regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of L-lysine import into cell" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane
relationship: positively_regulates GO:0097639 ! L-lysine import across plasma membrane

[Term]
id: GO:1905011
name: transmembrane phosphate ion transport from cytosol to vacuole
namespace: biological_process
alt_id: GO:0007037
def: "The directed movement of phosphate ions from the cytosol across the vacuolar membrane and into the vacuolar lumen." [GO_REF:0000078, GOC:TermGenie, PMID:26554016]
synonym: "vacuolar phosphate transport" BROAD []
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0035435 ! phosphate ion transmembrane transport

[Term]
id: GO:1905012
name: regulation of 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0090357 ! regulation of tryptophan metabolic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
is_a: GO:1902688 ! regulation of NAD metabolic process
relationship: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan

[Term]
id: GO:1905013
name: negative regulation of 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "down regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "down-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "downregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "inhibition of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie]
synonym: "inhibition of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "negative regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process
is_a: GO:1902689 ! negative regulation of NAD metabolic process
is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan
relationship: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan

[Term]
id: GO:1905014
name: positive regulation of 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie]
synonym: "activation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "positive regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "up regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "up regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "up-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "up-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "upregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "upregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0090358 ! positive regulation of tryptophan metabolic process
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
is_a: GO:1902690 ! positive regulation of NAD metabolic process
is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan
relationship: positively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan

[Term]
id: GO:1905015
name: obsolete regulation of isoleucine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905016
name: obsolete negative regulation of isoleucine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "inhibition of isoleucine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "negative regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905017
name: obsolete positive regulation of isoleucine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of isoleucine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "positive regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905018
name: obsolete regulation of methionine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of MetRS activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905019
name: obsolete negative regulation of methionine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "inhibition of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of methionine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of MetRS activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of MetRS activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905020
name: obsolete positive regulation of methionine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "activation of methionine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of MetRS activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of MetRS activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905021
name: obsolete regulation of threonine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of TRS" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905022
name: obsolete negative regulation of threonine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TRS" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRS" RELATED [GOC:TermGenie]
synonym: "downregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TRS" RELATED [GOC:TermGenie]
synonym: "inhibition of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of threonine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TRS" RELATED [GOC:TermGenie]
synonym: "negative regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TRS" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905023
name: obsolete positive regulation of threonine-tRNA ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "activation of threonine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of TRS" RELATED [GOC:TermGenie]
synonym: "positive regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of TRS" RELATED [GOC:TermGenie]
synonym: "up regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of TRS" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRS" RELATED [GOC:TermGenie]
synonym: "upregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of TRS" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905024
name: regulation of membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]
synonym: "regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "regulation of ventricular repolarization" RELATED [GOC:TermGenie]
is_a: GO:0060307 ! regulation of ventricular cardiac muscle cell membrane repolarization
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
relationship: regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential

[Term]
id: GO:1905025
name: negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]
synonym: "down regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "down regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "down regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "down-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "down-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "down-regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "downregulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "downregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "downregulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "inhibition of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "inhibition of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "inhibition of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "negative regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "negative regulation of ventricular repolarization" RELATED [GOC:TermGenie]
is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential
is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential
relationship: negatively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential

[Term]
id: GO:1905026
name: positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]
synonym: "activation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "activation of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "activation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "positive regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "positive regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "up regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "up regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "up regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "up-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "up-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "up-regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "upregulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "upregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "upregulation of ventricular repolarization" RELATED [GOC:TermGenie]
is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential
is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential
relationship: positively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential

[Term]
id: GO:1905027
name: regulation of membrane depolarization during AV node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]
synonym: "regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0098904 ! regulation of AV node cell action potential
is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential
relationship: regulates GO:0086045 ! membrane depolarization during AV node cell action potential

[Term]
id: GO:1905028
name: negative regulation of membrane depolarization during AV node cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]
synonym: "down regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1900826 ! negative regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential
relationship: negatively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential

[Term]
id: GO:1905029
name: positive regulation of membrane depolarization during AV node cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]
synonym: "activation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1900827 ! positive regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential
relationship: positively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential

[Term]
id: GO:1905030
name: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005]
subset: goslim_synapse
synonym: "voltage gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage gated ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential" BROAD []
is_a: GO:0005244 ! voltage-gated monoatomic ion channel activity

[Term]
id: GO:1905031
name: regulation of membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]
is_a: GO:0098903 ! regulation of membrane repolarization during action potential
is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization
relationship: regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential

[Term]
id: GO:1905032
name: negative regulation of membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]
synonym: "down regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
relationship: negatively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential

[Term]
id: GO:1905033
name: positive regulation of membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]
synonym: "activation of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
relationship: positively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential

[Term]
id: GO:1905034
name: regulation of antifungal innate immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:1900150 ! regulation of defense response to fungus
relationship: regulates GO:0061760 ! antifungal innate immune response

[Term]
id: GO:1905035
name: negative regulation of antifungal innate immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]
synonym: "down regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "down-regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "downregulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "inhibition of antifungal innate immune response" NARROW [GOC:TermGenie]
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:1905034 ! regulation of antifungal innate immune response
relationship: negatively_regulates GO:0061760 ! antifungal innate immune response

[Term]
id: GO:1905036
name: positive regulation of antifungal innate immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]
synonym: "activation of antifungal innate immune response" NARROW [GOC:TermGenie]
synonym: "up regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "up-regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "upregulation of antifungal innate immune response" EXACT [GOC:TermGenie]
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:1905034 ! regulation of antifungal innate immune response
relationship: positively_regulates GO:0061760 ! antifungal innate immune response

[Term]
id: GO:1905037
name: autophagosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024]
synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie]
synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie]
is_a: GO:0007033 ! vacuole organization
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:1905038
name: regulation of membrane lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280]
synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0006643 ! membrane lipid metabolic process

[Term]
id: GO:1905039
name: carboxylic acid transmembrane transport
namespace: biological_process
def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:1903825 ! organic acid transmembrane transport

[Term]
id: GO:1905040
name: otic placode development
namespace: biological_process
def: "The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]
synonym: "auditory placode development" RELATED [GOC:TermGenie]
synonym: "ear placode development" RELATED [GOC:TermGenie]
synonym: "ear/otic placode development" RELATED [GOC:TermGenie]
synonym: "octaval placode development" RELATED [GOC:TermGenie]
synonym: "octaval VIII placode development" RELATED [GOC:TermGenie]
synonym: "placoda otica development" EXACT [GOC:TermGenie]
is_a: GO:0071696 ! ectodermal placode development

[Term]
id: GO:1905041
name: regulation of epithelium regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]
synonym: "regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:1990399 ! epithelium regeneration

[Term]
id: GO:1905042
name: negative regulation of epithelium regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]
synonym: "down regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelium regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of regeneration of epithelium" NARROW [GOC:TermGenie]
synonym: "negative regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1905041 ! regulation of epithelium regeneration
relationship: negatively_regulates GO:1990399 ! epithelium regeneration

[Term]
id: GO:1905043
name: positive regulation of epithelium regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]
synonym: "activation of epithelium regeneration" NARROW [GOC:TermGenie]
synonym: "activation of regeneration of epithelium" NARROW [GOC:TermGenie]
synonym: "positive regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of regeneration of epithelium" EXACT [GOC:TermGenie]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1905041 ! regulation of epithelium regeneration
relationship: positively_regulates GO:1990399 ! epithelium regeneration

[Term]
id: GO:1905044
name: regulation of Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
relationship: regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration

[Term]
id: GO:1905045
name: negative regulation of Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]
synonym: "down regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie]
is_a: GO:0010626 ! negative regulation of Schwann cell proliferation
is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration
relationship: negatively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration

[Term]
id: GO:1905046
name: positive regulation of Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]
synonym: "activation of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
is_a: GO:0010625 ! positive regulation of Schwann cell proliferation
is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration
relationship: positively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration

[Term]
id: GO:1905047
name: mitotic spindle pole body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitotic spindle pole body." [GOC:TermGenie, PMID:24963130]
is_a: GO:0051300 ! spindle pole body organization

[Term]
id: GO:1905048
name: regulation of metallopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732]
subset: gocheck_obsoletion_candidate
synonym: "regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:1905049
name: negative regulation of metallopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "down regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metallopeptidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:1905048 ! regulation of metallopeptidase activity

[Term]
id: GO:1905050
name: positive regulation of metallopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732]
subset: gocheck_obsoletion_candidate
synonym: "activation of metallopeptidase activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metalloproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:1905048 ! regulation of metallopeptidase activity

[Term]
id: GO:1905051
name: regulation of base-excision repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]
synonym: "regulation of BER" EXACT [GOC:TermGenie]
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0006284 ! base-excision repair

[Term]
id: GO:1905052
name: negative regulation of base-excision repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]
synonym: "down regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "down regulation of BER" EXACT [GOC:TermGenie]
synonym: "down-regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of BER" EXACT [GOC:TermGenie]
synonym: "downregulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "downregulation of BER" EXACT [GOC:TermGenie]
synonym: "inhibition of base-excision repair" NARROW [GOC:TermGenie]
synonym: "inhibition of BER" NARROW [GOC:TermGenie]
synonym: "negative regulation of BER" EXACT [GOC:TermGenie]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:1905051 ! regulation of base-excision repair
relationship: negatively_regulates GO:0006284 ! base-excision repair

[Term]
id: GO:1905053
name: positive regulation of base-excision repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]
synonym: "activation of base-excision repair" NARROW [GOC:TermGenie]
synonym: "activation of BER" NARROW [GOC:TermGenie]
synonym: "positive regulation of BER" EXACT [GOC:TermGenie]
synonym: "up regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "up regulation of BER" EXACT [GOC:TermGenie]
synonym: "up-regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of BER" EXACT [GOC:TermGenie]
synonym: "upregulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "upregulation of BER" EXACT [GOC:TermGenie]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:1905051 ! regulation of base-excision repair
relationship: positively_regulates GO:0006284 ! base-excision repair

[Term]
id: GO:1905054
name: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:15919193, PMID:23918386]
subset: goslim_synapse
synonym: "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0048763 ! calcium-induced calcium release activity

[Term]
id: GO:1905055
name: calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962, PMID:23255722]
subset: goslim_synapse
synonym: "calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration" BROAD []
is_a: GO:0015368 ! calcium:monoatomic cation antiporter activity

[Term]
id: GO:1905056
name: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962]
subset: goslim_synapse
synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT []
synonym: "plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
is_a: GO:0005388 ! P-type calcium transporter activity

[Term]
id: GO:1905057
name: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20734177]
subset: goslim_synapse
synonym: "depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

[Term]
id: GO:1905058
name: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:23639769]
subset: goslim_synapse
synonym: "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
is_a: GO:0048763 ! calcium-induced calcium release activity

[Term]
id: GO:1905059
name: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20678993]
subset: goslim_synapse
synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT []
synonym: "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label []
synonym: "plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
is_a: GO:0005388 ! P-type calcium transporter activity

[Term]
id: GO:1905060
name: calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:18024055]
subset: goslim_synapse
synonym: "calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration" BROAD []
synonym: "calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels" EXACT syngo_official_label []
is_a: GO:0015368 ! calcium:monoatomic cation antiporter activity

[Term]
id: GO:1905061
name: negative regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097]
synonym: "down regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardioblast proliferation" NARROW [GOC:TermGenie]
is_a: GO:0003264 ! regulation of cardioblast proliferation
is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis
relationship: negatively_regulates GO:0003263 ! cardioblast proliferation

[Term]
id: GO:1905062
name: positive regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097]
synonym: "activation of cardioblast proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardioblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0003264 ! regulation of cardioblast proliferation
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
relationship: positively_regulates GO:0003263 ! cardioblast proliferation

[Term]
id: GO:1905063
name: regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
relationship: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation

[Term]
id: GO:1905064
name: negative regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
relationship: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation

[Term]
id: GO:1905065
name: positive regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
relationship: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation

[Term]
id: GO:1905066
name: obsolete regulation of canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0007507
consider: GO:0060828

[Term]
id: GO:1905067
name: obsolete negative regulation of canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0007507
consider: GO:0090090

[Term]
id: GO:1905068
name: obsolete positive regulation of canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0007507
consider: GO:0090263

[Term]
id: GO:1905069
name: allantois development
namespace: biological_process
def: "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579]
synonym: "allantoic bud development" RELATED [GOC:TermGenie]
is_a: GO:1903867 ! extraembryonic membrane development

[Term]
id: GO:1905070
name: anterior visceral endoderm cell migration
namespace: biological_process
def: "The orderly movement of an anterior visceral endoderm cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:17078044]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:1905071
name: tight junction disassembly
namespace: biological_process
def: "The disaggregation of an tight junction into its constituent components." [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "occluding junction disassembly" EXACT []
is_a: GO:0120193 ! tight junction organization
is_a: GO:0150147 ! cell-cell junction disassembly

[Term]
id: GO:1905072
name: cardiac jelly development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure. The cardiac jelly is an acellular gelatinous matrix secreted by the myocardium and plays a central role in the septation of the heart." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10645959, PMID:16314491, PMID:19703439]
synonym: "heart cardiac jelly development" EXACT [GOC:TermGenie]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:1905073
name: regulation of tight junction disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:1905071 ! tight junction disassembly

[Term]
id: GO:1905074
name: negative regulation of tight junction disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "down regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "down regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of occluding cell junction disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of occluding junction disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of tight junction disassembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905073 ! regulation of tight junction disassembly
relationship: negatively_regulates GO:1905071 ! tight junction disassembly

[Term]
id: GO:1905075
name: positive regulation of tight junction disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "activation of occluding cell junction disassembly" NARROW [GOC:TermGenie]
synonym: "activation of occluding junction disassembly" NARROW [GOC:TermGenie]
synonym: "activation of tight junction disassembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905073 ! regulation of tight junction disassembly
relationship: positively_regulates GO:1905071 ! tight junction disassembly

[Term]
id: GO:1905079
name: regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0098749 ! cerebellar neuron development

[Term]
id: GO:1905080
name: negative regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
synonym: "down regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "downregulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "inhibition of cerebellar neuron development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1905079 ! regulation of cerebellar neuron development
relationship: negatively_regulates GO:0098749 ! cerebellar neuron development

[Term]
id: GO:1905081
name: positive regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
synonym: "activation of cerebellar neuron development" NARROW [GOC:TermGenie]
synonym: "up regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "upregulation of cerebellar neuron development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1905079 ! regulation of cerebellar neuron development
relationship: positively_regulates GO:0098749 ! cerebellar neuron development

[Term]
id: GO:1905082
name: regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
is_a: GO:0006448 ! regulation of translational elongation
relationship: regulates GO:0070125 ! mitochondrial translational elongation

[Term]
id: GO:1905083
name: negative regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "down regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial translation elongation" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial translational elongation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:0070130 ! negative regulation of mitochondrial translation
is_a: GO:1905082 ! regulation of mitochondrial translational elongation
relationship: negatively_regulates GO:0070125 ! mitochondrial translational elongation

[Term]
id: GO:1905084
name: positive regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "activation of mitochondrial translation elongation" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial translational elongation" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:1905082 ! regulation of mitochondrial translational elongation
relationship: positively_regulates GO:0070125 ! mitochondrial translational elongation

[Term]
id: GO:1905085
name: regulation of bioluminescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0008218 ! bioluminescence

[Term]
id: GO:1905086
name: negative regulation of bioluminescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]
synonym: "down regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "down-regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "downregulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "inhibition of bioluminescence" NARROW [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1905085 ! regulation of bioluminescence
relationship: negatively_regulates GO:0008218 ! bioluminescence

[Term]
id: GO:1905087
name: positive regulation of bioluminescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]
synonym: "activation of bioluminescence" NARROW [GOC:TermGenie]
synonym: "up regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "up-regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "upregulation of bioluminescence" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1905085 ! regulation of bioluminescence
relationship: positively_regulates GO:0008218 ! bioluminescence

[Term]
id: GO:1905088
name: positive regulation of synaptonemal complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24797370]
synonym: "activation of synaptonemal complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of synaptonemal complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptonemal complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0090173 ! regulation of synaptonemal complex assembly
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0007130 ! synaptonemal complex assembly

[Term]
id: GO:1905089
name: regulation of type 2 mitophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type 2 mitophagy." [PMID:26942284]
synonym: "regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
is_a: GO:1901524 ! regulation of mitophagy
relationship: regulates GO:0061734 ! type 2 mitophagy

[Term]
id: GO:1905090
name: negative regulation of type 2 mitophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type 2 mitophagy." [GOC:vw, PMID:25009776, PMID:26942284]
synonym: "negative regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "negative regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
is_a: GO:1901525 ! negative regulation of mitophagy
is_a: GO:1905089 ! regulation of type 2 mitophagy
relationship: negatively_regulates GO:0061734 ! type 2 mitophagy

[Term]
id: GO:1905091
name: positive regulation of type 2 mitophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type 2 mitophagy." [GOC:vw, PMID:25009776, PMID:26942284]
synonym: "activation of parkin-mediated mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
synonym: "positive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT []
is_a: GO:1901526 ! positive regulation of mitophagy
is_a: GO:1905089 ! regulation of type 2 mitophagy
relationship: positively_regulates GO:0061734 ! type 2 mitophagy

[Term]
id: GO:1905092
name: response to diosgenin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]
is_a: GO:0036314 ! response to sterol
is_a: GO:0097305 ! response to alcohol
is_a: GO:1905836 ! response to triterpenoid

[Term]
id: GO:1905093
name: cellular response to diosgenin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1905092 ! response to diosgenin
is_a: GO:1905837 ! cellular response to triterpenoid

[Term]
id: GO:1905094
name: regulation of apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]
synonym: "regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway

[Term]
id: GO:1905095
name: negative regulation of apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]
synonym: "down regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway
relationship: negatively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway

[Term]
id: GO:1905096
name: positive regulation of apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]
synonym: "activation of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway
relationship: positively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway

[Term]
id: GO:1905097
name: regulation of guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009]
subset: gocheck_obsoletion_candidate
synonym: "regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "regulation of GDS" EXACT [GOC:TermGenie]
synonym: "regulation of GEF" EXACT [GOC:TermGenie]
synonym: "regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:1904424 ! regulation of GTP binding

[Term]
id: GO:1905098
name: negative regulation of guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GDS" EXACT [GOC:TermGenie]
synonym: "down regulation of GEF" EXACT [GOC:TermGenie]
synonym: "down regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "down regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GDS" EXACT [GOC:TermGenie]
synonym: "down-regulation of GEF" EXACT [GOC:TermGenie]
synonym: "down-regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "down-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "downregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GDS" EXACT [GOC:TermGenie]
synonym: "downregulation of GEF" EXACT [GOC:TermGenie]
synonym: "downregulation of GNRP" NARROW [GOC:TermGenie]
synonym: "downregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "inhibition of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GDS" NARROW [GOC:TermGenie]
synonym: "inhibition of GEF" NARROW [GOC:TermGenie]
synonym: "inhibition of GNRP" NARROW [GOC:TermGenie]
synonym: "inhibition of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie]
synonym: "negative regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GDS" EXACT [GOC:TermGenie]
synonym: "negative regulation of GEF" EXACT [GOC:TermGenie]
synonym: "negative regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "negative regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity

[Term]
id: GO:1905099
name: positive regulation of guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009]
subset: gocheck_obsoletion_candidate
synonym: "activation of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie]
synonym: "activation of GDS" NARROW [GOC:TermGenie]
synonym: "activation of GEF" NARROW [GOC:TermGenie]
synonym: "activation of GNRP" NARROW [GOC:TermGenie]
synonym: "activation of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie]
synonym: "activation of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie]
synonym: "activation of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie]
synonym: "positive regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GDS" EXACT [GOC:TermGenie]
synonym: "positive regulation of GEF" EXACT [GOC:TermGenie]
synonym: "positive regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "positive regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "up regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GDS" EXACT [GOC:TermGenie]
synonym: "up regulation of GEF" EXACT [GOC:TermGenie]
synonym: "up regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "up regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GDS" EXACT [GOC:TermGenie]
synonym: "up-regulation of GEF" EXACT [GOC:TermGenie]
synonym: "up-regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "up-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "upregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GDS" EXACT [GOC:TermGenie]
synonym: "upregulation of GEF" EXACT [GOC:TermGenie]
synonym: "upregulation of GNRP" NARROW [GOC:TermGenie]
synonym: "upregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
is_a: GO:1904426 ! positive regulation of GTP binding
is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity

[Term]
id: GO:1905100
name: regulation of apoptosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]
synonym: "regulation of apoptosome formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0097314 ! apoptosome assembly

[Term]
id: GO:1905101
name: negative regulation of apoptosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]
synonym: "down regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosome assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosome formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosome formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1905100 ! regulation of apoptosome assembly
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
relationship: negatively_regulates GO:0097314 ! apoptosome assembly

[Term]
id: GO:1905102
name: positive regulation of apoptosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]
synonym: "activation of apoptosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of apoptosome formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosome formation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1905100 ! regulation of apoptosome assembly
relationship: positively_regulates GO:0097314 ! apoptosome assembly

[Term]
id: GO:1905103
name: obsolete integral component of lysosomal membrane
namespace: cellular_component
def: "OBSOLETE. The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GO_REF:0000064, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26134396]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral component of lysosome membrane" EXACT [GOC:bf]
synonym: "integral to lysosomal membrane" NARROW []
is_obsolete: true
replaced_by: GO:0005765

[Term]
id: GO:1905104
name: obsolete response to ouabain
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1905105
name: obsolete cellular response to ouabain
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1905106
name: obsolete response to Dizocilpine
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1905107
name: obsolete cellular response to Dizocilpine
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1905108
name: guanosine binding
namespace: molecular_function
def: "Binding to guanosine." [GO_REF:0000067, GOC:TermGenie, PMID:26007660]
is_a: GO:0032550 ! purine ribonucleoside binding

[Term]
id: GO:1905109
name: regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "regulation of pulmonary blood vessel remodelling" EXACT []
is_a: GO:0060312 ! regulation of blood vessel remodeling
relationship: regulates GO:0101010 ! pulmonary blood vessel remodeling

[Term]
id: GO:1905110
name: negative regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "down regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "down-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "downregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "inhibition of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie]
synonym: "negative regulation of pulmonary blood vessel remodelling" EXACT []
is_a: GO:0060313 ! negative regulation of blood vessel remodeling
is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling
relationship: negatively_regulates GO:0101010 ! pulmonary blood vessel remodeling

[Term]
id: GO:1905111
name: positive regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "activation of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie]
synonym: "positive regulation of pulmonary blood vessel remodelling" EXACT []
synonym: "up regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "up-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "upregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling
is_a: GO:2000504 ! positive regulation of blood vessel remodeling
relationship: positively_regulates GO:0101010 ! pulmonary blood vessel remodeling

[Term]
id: GO:1905112
name: obsolete regulation of centromere clustering at the mitotic nuclear envelope
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
comment: This term was obsoleted because it represented a phenotype.
synonym: "regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "regulation of rabl configuration" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905113
name: obsolete positive regulation of centromere clustering at the mitotic nuclear envelope
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
comment: This term was obsoleted because it represented a phenotype.
synonym: "activation of centromere clustering at the nuclear envelope" NARROW [GOC:TermGenie]
synonym: "activation of centromere clustering at the nuclear periphery" NARROW [GOC:TermGenie]
synonym: "activation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "activation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "positive regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "positive regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "positive regulation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "up regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie]
synonym: "up regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "up regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up regulation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "up-regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up-regulation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "upregulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie]
synonym: "upregulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "upregulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "upregulation of rabl configuration" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905114
name: obsolete cell surface receptor signaling pathway involved in cell-cell signaling
namespace: biological_process
def: "OBSOLETE. Any cell surface receptor signaling pathway that is involved in cell-cell signaling." [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0]
comment: This term was obsoleted because it represents an unnecessary grouping class.
synonym: "cell surface receptor linked signal transduction involved in cell-cell signaling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signal transduction involved in cell-cell signalling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signaling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signalling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signalling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0007166

[Term]
id: GO:1905115
name: regulation of lateral attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore
relationship: regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:1905116
name: positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
synonym: "activation of lateral attachment of mitotic spindle microtubules to kinetochore" NARROW [GOC:TermGenie]
synonym: "up regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie]
synonym: "up-regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie]
synonym: "upregulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie]
is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore
is_a: GO:1905115 ! regulation of lateral attachment of mitotic spindle microtubules to kinetochore
relationship: positively_regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:1905117
name: regulation of ribonucleoside-diphosphate reductase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]
comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype).
subset: gocheck_obsoletion_candidate
synonym: "regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of ribonucleotide diphosphate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleotide reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of RNR" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:1905118
name: positive regulation of ribonucleoside-diphosphate reductase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]
comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype).
subset: gocheck_obsoletion_candidate
synonym: "activation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of RNR" RELATED [GOC:TermGenie]
synonym: "positive regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "positive regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of RNR" RELATED [GOC:TermGenie]
synonym: "up regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of RNR" RELATED [GOC:TermGenie]
synonym: "up-regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of RNR" RELATED [GOC:TermGenie]
synonym: "upregulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of RNR" RELATED [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1905117 ! regulation of ribonucleoside-diphosphate reductase activity

[Term]
id: GO:1905119
name: response to haloperidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1905120
name: cellular response to haloperidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1905119 ! response to haloperidol

[Term]
id: GO:1905123
name: regulation of glucosylceramidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]
subset: gocheck_obsoletion_candidate
synonym: "regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of GCase activity" EXACT [PMID:24334770]
synonym: "regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:1905124
name: obsolete negative regulation of glucosylceramidase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acid beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ceramide glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylcerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of psychosine hydrolase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GCase activity" EXACT [PMID:24334770]
synonym: "negative regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905125
name: obsolete positive regulation of glucosylceramidase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of acid beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of ceramide glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylcerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of psychosine hydrolase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GCase activity" EXACT [PMID:24334770]
synonym: "positive regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905126
name: regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:1905127
name: negative regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
relationship: negatively_regulates GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:1905128
name: positive regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
relationship: positively_regulates GO:0099640 ! axo-dendritic protein transport

[Term]
id: GO:1905129
name: endocannabinoid signaling pathway involved in trans-synaptic signaling
namespace: biological_process
def: "Any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid." [GO_REF:0000060, GOC:TermGenie, PMID:23040807]
synonym: "endocannabinoid signalling pathway involved in trans-synaptic signaling by endocannabinoid" EXACT [GOC:TermGenie]
is_a: GO:0071926 ! endocannabinoid signaling pathway
relationship: part_of GO:0099542 ! trans-synaptic signaling by endocannabinoid

[Term]
id: GO:1905130
name: carcinine import across plasma membrane
namespace: biological_process
def: "The directed movement of carcinine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:1905131
name: carcinine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carcinine from one side of a membrane to the other." [GO_REF:0000070, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:1905132
name: regulation of meiotic chromosome separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]
synonym: "regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
is_a: GO:1905818 ! regulation of chromosome separation
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:1905133
name: negative regulation of meiotic chromosome separation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]
synonym: "down regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "down regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "down regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "inhibition of chromosome separation during meiosis" NARROW [GOC:TermGenie]
synonym: "inhibition of meiotic chromosome resolution" NARROW [GOC:TermGenie]
synonym: "inhibition of meiotic chromosome separation" NARROW [GOC:TermGenie]
synonym: "negative regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
is_a: GO:1905132 ! regulation of meiotic chromosome separation
is_a: GO:1905819 ! negative regulation of chromosome separation
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:1905134
name: positive regulation of meiotic chromosome separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]
synonym: "activation of chromosome separation during meiosis" NARROW [GOC:TermGenie]
synonym: "activation of meiotic chromosome resolution" NARROW [GOC:TermGenie]
synonym: "activation of meiotic chromosome separation" NARROW [GOC:TermGenie]
synonym: "positive regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "up regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "up regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "up regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
is_a: GO:1905132 ! regulation of meiotic chromosome separation
is_a: GO:1905820 ! positive regulation of chromosome separation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:1905135
name: biotin import across plasma membrane
namespace: biological_process
alt_id: GO:0044756
alt_id: GO:1901689
def: "The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275]
synonym: "biotin import" RELATED []
synonym: "biotin import into cell" EXACT []
is_a: GO:0015878 ! biotin transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1905136
name: dethiobiotin import across plasma membrane
namespace: biological_process
alt_id: GO:0044757
alt_id: GO:1901690
def: "The directed movement of dethiobiotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275]
synonym: "dethiobiotin import" RELATED []
synonym: "dethiobiotin import into cell" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1905137
name: regulation of viral DNA genome packaging via site-specific sequence recognition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378]
is_a: GO:1903900 ! regulation of viral life cycle
relationship: regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition

[Term]
id: GO:1905138
name: positive regulation of viral DNA genome packaging via site-specific sequence recognition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378]
synonym: "activation of viral DNA genome packaging via site-specific sequence recognition" NARROW [GOC:TermGenie]
synonym: "up regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie]
synonym: "upregulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie]
is_a: GO:1903902 ! positive regulation of viral life cycle
is_a: GO:1905137 ! regulation of viral DNA genome packaging via site-specific sequence recognition
relationship: positively_regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition

[Term]
id: GO:1905139
name: apical ectodermal ridge formation
namespace: biological_process
def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583]
synonym: "AER formation" RELATED [GOC:TermGenie]
synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035107 ! appendage morphogenesis

[Term]
id: GO:1905140
name: regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:1905139 ! apical ectodermal ridge formation

[Term]
id: GO:1905141
name: negative regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "down regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "downregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "inhibition of AER formation" RELATED [GOC:TermGenie]
synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
relationship: negatively_regulates GO:1905139 ! apical ectodermal ridge formation

[Term]
id: GO:1905142
name: positive regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "activation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "upregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
relationship: positively_regulates GO:1905139 ! apical ectodermal ridge formation

[Term]
id: GO:1905143
name: eukaryotic translation initiation factor 2 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex." [GO_REF:0000079, GOC:TermGenie, PMID:23775072]
synonym: "eIF-2 assembly" EXACT [GOC:TermGenie]
synonym: "eIF-2 formation" EXACT [GOC:TermGenie]
synonym: "eIF2 assembly" EXACT [GOC:TermGenie]
synonym: "eIF2 formation" EXACT [GOC:TermGenie]
synonym: "eukaryotic translation initiation factor 2 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905144
name: response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905145
name: cellular response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905144 ! response to acetylcholine

[Term]
id: GO:1905146
name: lysosomal protein catabolic process
namespace: biological_process
def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]
comment: Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants.
synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "cellular protein catabolic process in lysosome" EXACT []
synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "lysosomal protein catabolism" EXACT [GOC:bf]
synonym: "lysosomal protein degradation" EXACT [GOC:bf]
synonym: "lysosomal proteolysis" RELATED [PMID:24334770]
synonym: "proteolysis within lysosome" RELATED [GOC:bf]
is_a: GO:0007039 ! protein catabolic process in the vacuole

[Term]
id: GO:1905147
name: regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0014895 ! smooth muscle hypertrophy

[Term]
id: GO:1905148
name: negative regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
relationship: negatively_regulates GO:0014895 ! smooth muscle hypertrophy

[Term]
id: GO:1905149
name: positive regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
relationship: positively_regulates GO:0014895 ! smooth muscle hypertrophy

[Term]
id: GO:1905150
name: regulation of voltage-gated sodium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377]
subset: gocheck_obsoletion_candidate
synonym: "regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1905151
name: negative regulation of voltage-gated sodium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive sodium channel" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity
is_a: GO:2001258 ! negative regulation of cation channel activity

[Term]
id: GO:1905152
name: positive regulation of voltage-gated sodium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377]
subset: gocheck_obsoletion_candidate
synonym: "activation of voltage gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-sensitive sodium channel" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:1905153
name: regulation of membrane invagination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0010324 ! membrane invagination

[Term]
id: GO:1905154
name: negative regulation of membrane invagination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
relationship: negatively_regulates GO:0010324 ! membrane invagination

[Term]
id: GO:1905155
name: positive regulation of membrane invagination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of membrane invagination" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
relationship: positively_regulates GO:0010324 ! membrane invagination

[Term]
id: GO:1905156
name: negative regulation of photosynthesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491]
synonym: "down regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of photosynthesis" NARROW [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0010109 ! regulation of photosynthesis
relationship: negatively_regulates GO:0015979 ! photosynthesis

[Term]
id: GO:1905157
name: positive regulation of photosynthesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491]
synonym: "activation of photosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of photosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0010109 ! regulation of photosynthesis
relationship: positively_regulates GO:0015979 ! photosynthesis

[Term]
id: GO:1905158
name: obsolete regulation of Factor XII activation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517]
comment: This term was accidentally approved after TermGenie review. It should not have been approved.
synonym: "regulation of Hageman factor activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905159
name: obsolete negative regulation of Factor XII activation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517]
comment: This term was accidentally approved after TermGenie review. It should not have been approved.
synonym: "down regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "down regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "downregulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "downregulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "inhibition of Factor XII activation" NARROW [GOC:TermGenie]
synonym: "inhibition of Hageman factor activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Hageman factor activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905160
name: obsolete positive regulation of Factor XII activation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517]
comment: This term was accidentally approved after TermGenie review. It should not have been approved.
synonym: "activation of Factor XII activation" NARROW [GOC:TermGenie]
synonym: "activation of Hageman factor activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "up regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "up regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "upregulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "upregulation of Hageman factor activation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905161
name: protein localization to phagocytic vesicle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671]
synonym: "protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein localisation to phagosome" EXACT [PMID:23303671]
synonym: "protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein recruitment to phagosome" EXACT [PMID:23303671]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:1905162
name: regulation of phagosome maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16908865, PMID:23303671]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0090382 ! phagosome maturation

[Term]
id: GO:1905163
name: negative regulation of phagosome maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of phagosome maturation" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1905162 ! regulation of phagosome maturation
relationship: negatively_regulates GO:0090382 ! phagosome maturation

[Term]
id: GO:1905164
name: positive regulation of phagosome maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of phagosome maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of phagosome maturation" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1905162 ! regulation of phagosome maturation
relationship: positively_regulates GO:0090382 ! phagosome maturation

[Term]
id: GO:1905165
name: regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937]
synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
relationship: regulates GO:1905146 ! lysosomal protein catabolic process

[Term]
id: GO:1905166
name: negative regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole
is_a: GO:1905165 ! regulation of lysosomal protein catabolic process
relationship: negatively_regulates GO:1905146 ! lysosomal protein catabolic process

[Term]
id: GO:1905167
name: positive regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole
is_a: GO:1905165 ! regulation of lysosomal protein catabolic process
relationship: positively_regulates GO:1905146 ! lysosomal protein catabolic process

[Term]
id: GO:1905168
name: positive regulation of double-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]
synonym: "activation of double-strand break repair via homologous recombination" NARROW [GOC:TermGenie]
synonym: "activation of HDR" NARROW [GOC:TermGenie]
synonym: "activation of homologous recombinational repair" NARROW [GOC:TermGenie]
synonym: "activation of homology-directed repair" NARROW [GOC:TermGenie]
synonym: "activation of HRR" NARROW [GOC:TermGenie]
synonym: "activation of Rad51-dependent recombinational repair" NARROW [GOC:TermGenie]
synonym: "activation of Rhp51-dependent recombinational repair" NARROW [GOC:TermGenie]
synonym: "positive regulation of HDR" EXACT [GOC:TermGenie]
synonym: "positive regulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "positive regulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "positive regulation of HRR" EXACT [GOC:TermGenie]
synonym: "positive regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "positive regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "up regulation of HDR" EXACT [GOC:TermGenie]
synonym: "up regulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "up regulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "up regulation of HRR" EXACT [GOC:TermGenie]
synonym: "up regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "up-regulation of HDR" EXACT [GOC:TermGenie]
synonym: "up-regulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of HRR" EXACT [GOC:TermGenie]
synonym: "up-regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "upregulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "upregulation of HDR" EXACT [GOC:TermGenie]
synonym: "upregulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "upregulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "upregulation of HRR" EXACT [GOC:TermGenie]
synonym: "upregulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "upregulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:2000781 ! positive regulation of double-strand break repair
relationship: positively_regulates GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:1905169
name: regulation of protein localization to phagocytic vesicle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:1905161 ! protein localization to phagocytic vesicle

[Term]
id: GO:1905170
name: negative regulation of protein localization to phagocytic vesicle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to phagosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein recruitment to phagosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle
relationship: negatively_regulates GO:1905161 ! protein localization to phagocytic vesicle

[Term]
id: GO:1905171
name: positive regulation of protein localization to phagocytic vesicle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671]
synonym: "activation of protein localisation in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to phagosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein recruitment to phagosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein recruitment to phagosome" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle
relationship: positively_regulates GO:1905161 ! protein localization to phagocytic vesicle

[Term]
id: GO:1905172
name: RISC complex binding
namespace: molecular_function
def: "Binding to a RISC complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364]
synonym: "RNA-induced silencing complex binding" EXACT [GOC:TermGenie]
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:1905173
name: eukaryotic translation initiation factor 2B complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2B complex." [GO_REF:0000079, GOC:TermGenie, PMID:27023709]
synonym: "eIF-2B assembly" EXACT [GOC:TermGenie]
synonym: "eIF-2B formation" EXACT [GOC:TermGenie]
synonym: "eif2B assembly" EXACT [GOC:TermGenie]
synonym: "eif2B formation" EXACT [GOC:TermGenie]
synonym: "eukaryotic translation initiation factor 2B complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905174
name: regulation of vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "regulation of vascular smooth muscle cell dedifferentiation" EXACT []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation

[Term]
id: GO:1905175
name: negative regulation of vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "down regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell dedifferentiation" EXACT []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation
relationship: negatively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation

[Term]
id: GO:1905176
name: positive regulation of vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "activation of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell dedifferentiation" EXACT []
synonym: "up regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation
relationship: positively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation

[Term]
id: GO:1905177
name: tracheary element differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a tracheary element." [GO_REF:0000086, GOC:TermGenie, PMID:20659276]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:1905178
name: regulation of cardiac muscle tissue regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0061026 ! cardiac muscle tissue regeneration

[Term]
id: GO:1905179
name: negative regulation of cardiac muscle tissue regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]
synonym: "down regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration
relationship: negatively_regulates GO:0061026 ! cardiac muscle tissue regeneration

[Term]
id: GO:1905180
name: positive regulation of cardiac muscle tissue regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]
synonym: "activation of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration
relationship: positively_regulates GO:0061026 ! cardiac muscle tissue regeneration

[Term]
id: GO:1905181
name: regulation of urease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of urease activity." [GO_REF:0000059, GOC:TermGenie, PMID:16244137]
subset: gocheck_obsoletion_candidate
synonym: "regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:1905182
name: obsolete positive regulation of urease activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of urease activity." [GO_REF:0000059, GOC:TermGenie, PMID:16244137]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of urea amidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of urease activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of urease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of urease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of urea amidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of urease activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905183
name: obsolete negative regulation of protein serine/threonine phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein serine/threonine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:16950131]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "down regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of protein serine/threonine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine/threonine specific protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905184
name: obsolete positive regulation of protein serine/threonine phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:16950131]
comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
synonym: "activation of protein serine/threonine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of serine/threonine specific protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905186
name: regulation of metaphase/anaphase transition of meiosis I
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117]
synonym: "regulation of first meiotic metaphase/anaphase transition" RELATED [GOC:TermGenie]
synonym: "regulation of meiosis I metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle
relationship: regulates GO:1990949 ! metaphase/anaphase transition of meiosis I

[Term]
id: GO:1905187
name: negative regulation of metaphase/anaphase transition of meiosis I
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117]
is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905186 ! regulation of metaphase/anaphase transition of meiosis I
relationship: negatively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I

[Term]
id: GO:1905188
name: positive regulation of metaphase/anaphase transition of meiosis I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117]
synonym: "positive regulation of meiosis I metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1902104 ! positive regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905186 ! regulation of metaphase/anaphase transition of meiosis I
relationship: positively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I

[Term]
id: GO:1905189
name: regulation of metaphase/anaphase transition of meiosis II
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117]
synonym: "regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle
relationship: regulates GO:1990950 ! metaphase/anaphase transition of meiosis II

[Term]
id: GO:1905190
name: negative regulation of metaphase/anaphase transition of meiosis II
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117]
synonym: "negative regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905189 ! regulation of metaphase/anaphase transition of meiosis II
relationship: negatively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II

[Term]
id: GO:1905191
name: positive regulation of metaphase/anaphase transition of meiosis II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117]
synonym: "positive regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1902104 ! positive regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905189 ! regulation of metaphase/anaphase transition of meiosis II
relationship: positively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II

[Term]
id: GO:1905192
name: regulation of chloroplast fission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170]
comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments.
synonym: "regulation of chloroplast division" EXACT [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0010020 ! chloroplast fission

[Term]
id: GO:1905193
name: negative regulation of chloroplast fission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170]
comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments.
synonym: "down regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "down regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "down-regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "down-regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "downregulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "downregulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "inhibition of chloroplast division" NARROW [GOC:TermGenie]
synonym: "inhibition of chloroplast fission" NARROW [GOC:TermGenie]
synonym: "negative regulation of chloroplast division" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1905192 ! regulation of chloroplast fission
relationship: negatively_regulates GO:0010020 ! chloroplast fission

[Term]
id: GO:1905194
name: positive regulation of chloroplast fission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170]
comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments.
synonym: "activation of chloroplast division" NARROW [GOC:TermGenie]
synonym: "activation of chloroplast fission" NARROW [GOC:TermGenie]
synonym: "positive regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "up regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "up regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "up-regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "up-regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "upregulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "upregulation of chloroplast fission" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1905192 ! regulation of chloroplast fission
relationship: positively_regulates GO:0010020 ! chloroplast fission

[Term]
id: GO:1905195
name: obsolete regulation of ATPase activity, uncoupled
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATPase activity, uncoupled." [GO_REF:0000059, GOC:TermGenie, PMID:26545917]
comment: The reason for obsoletion is that the there is no convincing example of a protein with this function.
synonym: "regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905196
name: obsolete positive regulation of ATPase activity, uncoupled
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATPase activity, uncoupled." [GO_REF:0000059, GOC:TermGenie, PMID:26545917]
comment: The reason for obsoletion is that the there is no convincing example of a protein with this function.
synonym: "activation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie]
synonym: "activation of ATPase activity, uncoupled" NARROW [GOC:TermGenie]
synonym: "positive regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie]
synonym: "up-regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie]
synonym: "upregulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905197
name: endocannabinoid signaling pathway involved in retrograde trans-synaptic signaling
namespace: biological_process
def: "Any endocannabinoid signaling pathway that is involved in retrograde trans-synaptic signaling by endocannabinoid." [GO_REF:0000060, GOC:TermGenie, PMID:23040807]
synonym: "endocannabinoid signalling pathway involved in retrograde trans-synaptic signaling by endocannabinoid" EXACT [GOC:TermGenie]
is_a: GO:1905129 ! endocannabinoid signaling pathway involved in trans-synaptic signaling
relationship: part_of GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid

[Term]
id: GO:1905198
name: manchette assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a manchette." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866]
synonym: "manchette formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:1905199
name: manchette disassembly
namespace: biological_process
def: "The disaggregation of a manchette into its constituent components." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866]
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:1905200
name: gibberellic acid transmembrane transport
namespace: biological_process
def: "The directed movement of gibberellic acid across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:27139299]
is_a: GO:0046865 ! terpenoid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:1905201
name: gibberellin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of gibberellin from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, PMID:27139299]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0170055 ! lipid transmembrane transporter activity

[Term]
id: GO:1905202
name: methylcrotonoyl-CoA carboxylase complex
namespace: cellular_component
def: "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1905203
name: regulation of connective tissue replacement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0097709 ! connective tissue replacement

[Term]
id: GO:1905204
name: negative regulation of connective tissue replacement
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]
synonym: "down regulation of connective tissue replacement" EXACT [GOC:TermGenie]
synonym: "down-regulation of connective tissue replacement" EXACT [GOC:TermGenie]
synonym: "downregulation of connective tissue replacement" EXACT [GOC:TermGenie]
synonym: "inhibition of connective tissue replacement" NARROW [GOC:TermGenie]
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:1905203 ! regulation of connective tissue replacement
relationship: negatively_regulates GO:0097709 ! connective tissue replacement

[Term]
id: GO:1905205
name: positive regulation of connective tissue replacement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]
synonym: "activation of connective tissue replacement" NARROW [GOC:TermGenie]
synonym: "up regulation of connective tissue replacement" EXACT [GOC:TermGenie]
synonym: "up-regulation of connective tissue replacement" EXACT [GOC:TermGenie]
synonym: "upregulation of connective tissue replacement" EXACT [GOC:TermGenie]
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:1905203 ! regulation of connective tissue replacement
relationship: positively_regulates GO:0097709 ! connective tissue replacement

[Term]
id: GO:1905206
name: obsolete positive regulation of hydrogen peroxide-induced cell death
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:20550618]
comment: The reason for obsoletion is that this term represent an assay or a phenotype.
synonym: "activation of cell death in response to H2O2" NARROW [GOC:TermGenie]
synonym: "activation of cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell death in response to hydrogen peroxide" EXACT []
synonym: "positive regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "up regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "upregulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "upregulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905207
name: regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:1905208
name: negative regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905207 ! regulation of cardiocyte differentiation
relationship: negatively_regulates GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:1905209
name: positive regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie]
synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905207 ! regulation of cardiocyte differentiation
relationship: positively_regulates GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:1905210
name: regulation of fibroblast chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:1990956 ! fibroblast chemotaxis

[Term]
id: GO:1905211
name: negative regulation of fibroblast chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137]
synonym: "down regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie]
synonym: "downregulation of fibroblast chemotaxis" EXACT [GOC:TermGenie]
synonym: "inhibition of fibroblast chemotaxis" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1905210 ! regulation of fibroblast chemotaxis
relationship: negatively_regulates GO:1990956 ! fibroblast chemotaxis

[Term]
id: GO:1905212
name: positive regulation of fibroblast chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137]
synonym: "activation of fibroblast chemotaxis" NARROW [GOC:TermGenie]
synonym: "up regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie]
synonym: "upregulation of fibroblast chemotaxis" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1905210 ! regulation of fibroblast chemotaxis
relationship: positively_regulates GO:1990956 ! fibroblast chemotaxis

[Term]
id: GO:1905213
name: negative regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1902340 ! negative regulation of chromosome condensation
is_a: GO:1903379 ! regulation of mitotic chromosome condensation
relationship: negatively_regulates GO:0007076 ! mitotic chromosome condensation

[Term]
id: GO:1905214
name: regulation of RNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:1905215
name: negative regulation of RNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1905214 ! regulation of RNA binding

[Term]
id: GO:1905216
name: positive regulation of RNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]
subset: gocheck_do_not_annotate
synonym: "activation of RNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1905214 ! regulation of RNA binding

[Term]
id: GO:1905217
name: response to astaxanthin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505]
synonym: "response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT []
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:1905218
name: cellular response to astaxanthin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505]
synonym: "cellular response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT []
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1905217 ! response to astaxanthin

[Term]
id: GO:1905219
name: regulation of platelet formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160]
synonym: "regulation of platelet extrusion" EXACT [GOC:TermGenie]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: regulates GO:0030220 ! platelet formation

[Term]
id: GO:1905220
name: negative regulation of platelet formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160]
synonym: "down regulation of platelet extrusion" EXACT [GOC:TermGenie]
synonym: "down regulation of platelet formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of platelet extrusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of platelet formation" EXACT [GOC:TermGenie]
synonym: "downregulation of platelet extrusion" EXACT [GOC:TermGenie]
synonym: "downregulation of platelet formation" EXACT [GOC:TermGenie]
synonym: "inhibition of platelet extrusion" NARROW [GOC:TermGenie]
synonym: "inhibition of platelet formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of platelet extrusion" EXACT [GOC:TermGenie]
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:1905219 ! regulation of platelet formation
relationship: negatively_regulates GO:0030220 ! platelet formation

[Term]
id: GO:1905221
name: positive regulation of platelet formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160]
synonym: "activation of platelet extrusion" NARROW [GOC:TermGenie]
synonym: "activation of platelet formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of platelet extrusion" EXACT [GOC:TermGenie]
synonym: "up regulation of platelet extrusion" EXACT [GOC:TermGenie]
synonym: "up regulation of platelet formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of platelet extrusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of platelet formation" EXACT [GOC:TermGenie]
synonym: "upregulation of platelet extrusion" EXACT [GOC:TermGenie]
synonym: "upregulation of platelet formation" EXACT [GOC:TermGenie]
is_a: GO:0010770 ! positive regulation of cell morphogenesis
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:1905219 ! regulation of platelet formation
relationship: positively_regulates GO:0030220 ! platelet formation

[Term]
id: GO:1905222
name: atrioventricular canal morphogenesis
namespace: biological_process
def: "The developmental process by which an atrioventricular canal is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19703439]
synonym: "atrial canal morphogenesis" EXACT [GOC:TermGenie]
synonym: "atrio-ventricular canal morphogenesis" EXACT [GOC:TermGenie]
synonym: "AV canal morphogenesis" EXACT [GOC:TermGenie]
synonym: "AVC morphogenesis" EXACT [GOC:TermGenie]
synonym: "canalis atrioventricularis morphogenesis" RELATED [GOC:TermGenie]
synonym: "ependymal canal morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0036302 ! atrioventricular canal development

[Term]
id: GO:1905223
name: epicardium morphogenesis
namespace: biological_process
def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie]
synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie]
synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie]
synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:1905224
name: obsolete clathrin-coated pit assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a clathrin-coated pit." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
comment: The reason for obsoletion is this term is describing a process similar to that of clathrin coat assembly.
synonym: "clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "coated pit assembly" EXACT [GOC:TermGenie]
synonym: "coated pit formation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0048268

[Term]
id: GO:1905225
name: response to thyrotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:21382270]
synonym: "response to protirelin" EXACT []
synonym: "response to TRH" RELATED []
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:1905226
name: obsolete regulation of adhesion of symbiont to host epithelial cell
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068]
comment: The reason for obsoletion is that these terms are poorly defined and have been used inconsistently.
is_obsolete: true

[Term]
id: GO:1905227
name: obsolete negative regulation of adhesion of symbiont to host epithelial cell
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068]
comment: The reason for obsoletion is that these terms are poorly defined and have been used inconsistently.
synonym: "down regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie]
synonym: "downregulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie]
synonym: "inhibition of adhesion of symbiont to host epithelial cell" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905228
name: obsolete positive regulation of adhesion of symbiont to host epithelial cell
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068]
comment: The reason for obsoletion is that these terms are poorly defined and have been used inconsistently.
synonym: "activation of adhesion of symbiont to host epithelial cell" NARROW [GOC:TermGenie]
synonym: "up regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie]
synonym: "upregulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905229
name: cellular response to thyrotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [GO_REF:0000071, GOC:TermGenie, PMID:21382270]
synonym: "cellular response to protirelin" EXACT []
synonym: "cellular response to TRH" RELATED []
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1905225 ! response to thyrotropin-releasing hormone

[Term]
id: GO:1905230
name: response to borneol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26593909]
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:1905231
name: cellular response to borneol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26593909]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1905230 ! response to borneol

[Term]
id: GO:1905232
name: cellular response to L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137]
synonym: "cellular response to L-glutamate(1-)" RELATED []
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902065 ! response to L-glutamate

[Term]
id: GO:1905233
name: response to codeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
is_a: GO:0014072 ! response to isoquinoline alkaloid

[Term]
id: GO:1905234
name: cellular response to codeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid
is_a: GO:1905233 ! response to codeine

[Term]
id: GO:1905235
name: response to quercetin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
is_a: GO:1905395 ! response to flavonoid

[Term]
id: GO:1905236
name: cellular response to quercetin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
is_a: GO:1905235 ! response to quercetin
is_a: GO:1905396 ! cellular response to flavonoid

[Term]
id: GO:1905237
name: response to cyclosporin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
synonym: "response to cyclophilin" EXACT []
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905238
name: cellular response to cyclosporin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
synonym: "cellular response to cyclophilin" EXACT []
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905237 ! response to cyclosporin A

[Term]
id: GO:1905239
name: obsolete regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0001649
consider: GO:0060828

[Term]
id: GO:1905240
name: obsolete negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0001649
consider: GO:0090090

[Term]
id: GO:1905241
name: obsolete positive regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0001649
consider: GO:0090263

[Term]
id: GO:1905242
name: response to 3,3',5-triiodo-L-thyronine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21382270]
synonym: "response to Liothyronin" EXACT []
synonym: "response to Liothyronine" EXACT []
synonym: "response to Liothyroninum" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905243
name: cellular response to 3,3',5-triiodo-L-thyronine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21382270]
synonym: "cellular response to Liothyronin" EXACT []
synonym: "cellular response to Liothyronine" EXACT []
synonym: "cellular response to Liothyroninum" EXACT []
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905242 ! response to 3,3',5-triiodo-L-thyronine

[Term]
id: GO:1905244
name: regulation of modification of synaptic structure
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of modification of synaptic structure." [GO_REF:0000058, GOC:TermGenie, PMID:25164660]
subset: goslim_synapse
synonym: "regulation of synapse remodelling" EXACT [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0099563 ! modification of synaptic structure

[Term]
id: GO:1905245
name: regulation of aspartic-type peptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575]
subset: gocheck_obsoletion_candidate
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:1905246
name: negative regulation of aspartic-type peptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of aspartic-type peptidase activity" NARROW [GOC:TermGenie]
synonym: "pepsin inhibitor" RELATED []
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:1905245 ! regulation of aspartic-type peptidase activity

[Term]
id: GO:1905247
name: positive regulation of aspartic-type peptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575]
subset: gocheck_obsoletion_candidate
synonym: "activation of aspartic-type peptidase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:1905245 ! regulation of aspartic-type peptidase activity

[Term]
id: GO:1905248
name: obsolete regulation of memory
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "modulation of memory" NARROW []
is_obsolete: true

[Term]
id: GO:1905249
name: obsolete negative regulation of memory
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "inhibition of memory" NARROW [GOC:TermGenie]
synonym: "suppression of memory" EXACT []
is_obsolete: true

[Term]
id: GO:1905250
name: obsolete positive regulation of memory
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "enhancement of memory" NARROW []
is_obsolete: true

[Term]
id: GO:1905251
name: epidermal growth factor receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: part_of GO:0003015 ! heart process

[Term]
id: GO:1905252
name: obsolete regulation of epidermal growth factor receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905253
name: obsolete negative regulation of epidermal growth factor receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any negative regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905254
name: obsolete positive regulation of epidermal growth factor receptor signaling pathway involved in heart process
namespace: biological_process
def: "OBSOLETE. Any positive regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "stimulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "stimulation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905255
name: regulation of RNA binding transcription factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]
subset: gocheck_obsoletion_candidate
synonym: "regulation of transcription factor activity" BROAD [GOC:TermGenie]
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:1905256
name: obsolete negative regulation of RNA binding transcription factor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA binding transcription factor activity" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905257
name: obsolete positive regulation of RNA binding transcription factor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of RNA binding transcription factor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905258
name: regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf]
synonym: "regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress

[Term]
id: GO:1905259
name: negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie]
synonym: "down regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to nitrosative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of nitrosative stress-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf]
synonym: "negative regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1905258 ! regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress

[Term]
id: GO:1905260
name: positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to nitrosative stress" NARROW [GOC:TermGenie]
synonym: "activation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "activation of nitrosative stress-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf]
synonym: "positive regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie]
synonym: "up regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1905258 ! regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress

[Term]
id: GO:1905261
name: regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857]
is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation
relationship: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

[Term]
id: GO:1905262
name: negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857]
synonym: "down regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" NARROW [GOC:TermGenie]
is_a: GO:1903342 ! negative regulation of meiotic DNA double-strand break formation
is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
relationship: negatively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

[Term]
id: GO:1905263
name: positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857]
synonym: "activation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" NARROW [GOC:TermGenie]
synonym: "up regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie]
is_a: GO:1903343 ! positive regulation of meiotic DNA double-strand break formation
is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
relationship: positively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

[Term]
id: GO:1905264
name: blasticidin S metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S]
synonym: "blasticidin S metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process

[Term]
id: GO:1905265
name: blasticidin S catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S]
synonym: "blasticidin S breakdown" EXACT [GOC:TermGenie]
synonym: "blasticidin S catabolism" EXACT [GOC:TermGenie]
synonym: "blasticidin S degradation" EXACT [GOC:TermGenie]
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process
is_a: GO:1905264 ! blasticidin S metabolic process

[Term]
id: GO:1905266
name: blasticidin S biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S]
synonym: "blasticidin S anabolism" EXACT [GOC:TermGenie]
synonym: "blasticidin S biosynthesis" EXACT [GOC:TermGenie]
synonym: "blasticidin S formation" EXACT [GOC:TermGenie]
synonym: "blasticidin S synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process
is_a: GO:1905264 ! blasticidin S metabolic process

[Term]
id: GO:1905267
name: obsolete endonucleolytic cleavage involved in tRNA processing
namespace: biological_process
def: "OBSOLETE. Any endonucleolytic RNA phosphodiester bond hydrolysis that is involved in tRNA processing." [GO_REF:0000060, GOC:TermGenie, PMID:25401760]
comment: The reason for obsoletion is that the term represents a molecular function.
synonym: "RNA phosphodiester bond hydrolysis, endonucleolytic involved in tRNA maturation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0042780

[Term]
id: GO:1905268
name: negative regulation of chromatin organization
namespace: biological_process
alt_id: GO:0045798
alt_id: GO:1903309
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]
synonym: "down regulation of chromatin assembly or disassembly" RELATED []
synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin assembly or disassembly" RELATED []
synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin assembly or disassembly" RELATED []
synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "inhibition of chromatin assembly or disassembly" NARROW []
synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie]
synonym: "negative regulation of chromatin assembly or disassembly" RELATED []
synonym: "negative regulation of chromatin assembly/disassembly" EXACT []
synonym: "negative regulation of chromatin modification" RELATED []
synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1902275 ! regulation of chromatin organization
relationship: negatively_regulates GO:0006325 ! chromatin organization

[Term]
id: GO:1905269
name: positive regulation of chromatin organization
namespace: biological_process
alt_id: GO:0045799
alt_id: GO:1903310
def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]
synonym: "activation of chromatin assembly or disassembly" NARROW []
synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie]
synonym: "activation of chromatin organization" NARROW [GOC:TermGenie]
synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie]
synonym: "positive regulation of chromatin assembly or disassembly" RELATED []
synonym: "positive regulation of chromatin assembly/disassembly" RELATED []
synonym: "positive regulation of chromatin modification" RELATED []
synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "stimulation of chromatin assembly or disassembly" NARROW []
synonym: "up regulation of chromatin assembly or disassembly" RELATED []
synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin assembly or disassembly" RELATED []
synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin assembly or disassembly" EXACT []
synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:1902275 ! regulation of chromatin organization
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0006325 ! chromatin organization

[Term]
id: GO:1905270
name: Meynert cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a Meynert cell." [GO_REF:0000086, GOC:TermGenie, PMID:4142639]
is_a: GO:0021859 ! pyramidal neuron differentiation
is_a: GO:0021895 ! cerebral cortex neuron differentiation

[Term]
id: GO:1905271
name: regulation of proton-transporting ATP synthase activity, rotational mechanism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936]
subset: gocheck_obsoletion_candidate
synonym: "regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0051340 ! regulation of ligase activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:1905272
name: obsolete negative regulation of proton-transporting ATP synthase activity, rotational mechanism
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "downregulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "inhibition of H+-transporting ATP synthase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen ion translocating F-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen ion transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen ion transporting two-sector ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of proton-transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie]
synonym: "negative regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905273
name: positive regulation of proton-transporting ATP synthase activity, rotational mechanism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936]
subset: gocheck_obsoletion_candidate
synonym: "activation of H+-transporting ATP synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen ion translocating F-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen ion transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen ion transporting two-sector ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of proton-transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie]
synonym: "positive regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "upregulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
is_a: GO:0051351 ! positive regulation of ligase activity
is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism
is_a: GO:2001259 ! positive regulation of cation channel activity

[Term]
id: GO:1905274
name: regulation of modification of postsynaptic actin cytoskeleton
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton." [GO_REF:0000058, GOC:TermGenie, PMID:21068295]
subset: goslim_synapse
synonym: "regulation of postsynaptic actin cytoskeleton remodelling" EXACT [GOC:TermGenie]
is_a: GO:0099159 ! regulation of modification of postsynaptic structure
relationship: regulates GO:0098885 ! modification of postsynaptic actin cytoskeleton

[Term]
id: GO:1905275
name: Rohon-Beard neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a Rohon-Beard neuron." [GO_REF:0000086, GOC:TermGenie, ZFIN:ZDB-PUB-120807-45]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:1905276
name: regulation of epithelial tube formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0072175 ! epithelial tube formation

[Term]
id: GO:1905277
name: negative regulation of epithelial tube formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0072175 ! epithelial tube formation

[Term]
id: GO:1905278
name: positive regulation of epithelial tube formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0072175 ! epithelial tube formation

[Term]
id: GO:1905279
name: regulation of retrograde transport, endosome to Golgi
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23395371]
synonym: "regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0042147 ! retrograde transport, endosome to Golgi

[Term]
id: GO:1905280
name: negative regulation of retrograde transport, endosome to Golgi
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
synonym: "down regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie]
synonym: "inhibition of retrograde (endosome to Golgi) transport" NARROW [GOC:TermGenie]
synonym: "inhibition of retrograde transport, endosome to Golgi" NARROW [GOC:TermGenie]
synonym: "negative regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1905279 ! regulation of retrograde transport, endosome to Golgi
relationship: negatively_regulates GO:0042147 ! retrograde transport, endosome to Golgi

[Term]
id: GO:1905281
name: positive regulation of retrograde transport, endosome to Golgi
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of retrograde (endosome to Golgi) transport" NARROW [GOC:TermGenie]
synonym: "activation of retrograde transport, endosome to Golgi" NARROW [GOC:TermGenie]
synonym: "positive regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
synonym: "up regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
synonym: "up regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1905279 ! regulation of retrograde transport, endosome to Golgi
relationship: positively_regulates GO:0042147 ! retrograde transport, endosome to Golgi

[Term]
id: GO:1905282
name: regulation of epidermal growth factor receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
relationship: regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process

[Term]
id: GO:1905283
name: negative regulation of epidermal growth factor receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "down regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "inhibition of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of EGF receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of EGF receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of EGFR signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of epidermal growth factor receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of ERBB1 signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905282 ! regulation of epidermal growth factor receptor signaling pathway involved in heart process
relationship: negatively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process

[Term]
id: GO:1905284
name: positive regulation of epidermal growth factor receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "activation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of EGF receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of EGF receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of EGFR signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of epidermal growth factor receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of ERBB1 signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie]
synonym: "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie]
is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905282 ! regulation of epidermal growth factor receptor signaling pathway involved in heart process
relationship: positively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process

[Term]
id: GO:1905285
name: fibrous ring of heart morphogenesis
namespace: biological_process
def: "The developmental process by which a fibrous ring of heart is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16037571]
synonym: "annulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie]
synonym: "anulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie]
synonym: "anulus fibrosus of heart morphogenesis" EXACT [GOC:TermGenie]
synonym: "aortic annulus morphogenesis" RELATED [GOC:TermGenie]
synonym: "atrioventricular ring morphogenesis" RELATED [GOC:TermGenie]
synonym: "coronary tendon morphogenesis" RELATED [GOC:TermGenie]
synonym: "Lower's ring morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0048729 ! tissue morphogenesis

[Term]
id: GO:1905286
name: serine-type peptidase complex
namespace: cellular_component
def: "A protein complex which is capable of serine-type peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965]
comment: An example of this is F7 in human (P08709) in PMID:18640965 (inferred from direct assay).
synonym: "Factor VII - TF complex" NARROW []
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:1905287
name: positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation
namespace: biological_process
def: "Any positive regulation of G2/M transition of mitotic cell cycle that is involved in cellular response to nitrogen starvation." [GO_REF:0000060, GOC:TermGenie, PMID:26776736]
synonym: "positive regulation of mitotic entry involved in cellular response to nitrogen starvation" EXACT [GOC:TermGenie]
is_a: GO:0010971 ! positive regulation of G2/M transition of mitotic cell cycle
relationship: part_of GO:0006995 ! cellular response to nitrogen starvation

[Term]
id: GO:1905288
name: vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:1905289
name: regulation of CAMKK-AMPK signaling cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786]
synonym: "regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
is_a: GO:0050848 ! regulation of calcium-mediated signaling
relationship: regulates GO:0061762 ! CAMKK-AMPK signaling cascade

[Term]
id: GO:1905290
name: negative regulation of CAMKK-AMPK signaling cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786]
synonym: "down regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of CAMKK-AMPK signaling cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
is_a: GO:0050849 ! negative regulation of calcium-mediated signaling
is_a: GO:1905289 ! regulation of CAMKK-AMPK signaling cascade
relationship: negatively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade

[Term]
id: GO:1905291
name: positive regulation of CAMKK-AMPK signaling cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786]
synonym: "activation of CAMKK-AMPK signaling cascade" NARROW [GOC:TermGenie]
synonym: "activation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:1905289 ! regulation of CAMKK-AMPK signaling cascade
relationship: positively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade

[Term]
id: GO:1905292
name: regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
is_a: GO:2000736 ! regulation of stem cell differentiation
relationship: regulates GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:1905293
name: negative regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905292 ! regulation of neural crest cell differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
relationship: negatively_regulates GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:1905294
name: positive regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905292 ! regulation of neural crest cell differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
relationship: positively_regulates GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:1905295
name: regulation of neural crest cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0090299 ! regulation of neural crest formation
is_a: GO:1905292 ! regulation of neural crest cell differentiation
relationship: regulates GO:0014036 ! neural crest cell fate specification

[Term]
id: GO:1905296
name: negative regulation of neural crest cell fate specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "down regulation of neural crest cell fate specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of neural crest cell fate specification" EXACT [GOC:TermGenie]
synonym: "downregulation of neural crest cell fate specification" EXACT [GOC:TermGenie]
synonym: "inhibition of neural crest cell fate specification" NARROW [GOC:TermGenie]
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0090301 ! negative regulation of neural crest formation
is_a: GO:1905293 ! negative regulation of neural crest cell differentiation
is_a: GO:1905295 ! regulation of neural crest cell fate specification
relationship: negatively_regulates GO:0014036 ! neural crest cell fate specification

[Term]
id: GO:1905297
name: positive regulation of neural crest cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "activation of neural crest cell fate specification" NARROW [GOC:TermGenie]
synonym: "up regulation of neural crest cell fate specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of neural crest cell fate specification" EXACT [GOC:TermGenie]
synonym: "upregulation of neural crest cell fate specification" EXACT [GOC:TermGenie]
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:0090300 ! positive regulation of neural crest formation
is_a: GO:1905294 ! positive regulation of neural crest cell differentiation
is_a: GO:1905295 ! regulation of neural crest cell fate specification
relationship: positively_regulates GO:0014036 ! neural crest cell fate specification

[Term]
id: GO:1905298
name: regulation of intestinal epithelial cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0060576 ! intestinal epithelial cell development

[Term]
id: GO:1905299
name: negative regulation of intestinal epithelial cell development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]
synonym: "down regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "down-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "downregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "inhibition of intestinal epithelial cell development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905298 ! regulation of intestinal epithelial cell development
relationship: negatively_regulates GO:0060576 ! intestinal epithelial cell development

[Term]
id: GO:1905300
name: positive regulation of intestinal epithelial cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]
synonym: "activation of intestinal epithelial cell development" NARROW [GOC:TermGenie]
synonym: "up regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "up-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "upregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905298 ! regulation of intestinal epithelial cell development
relationship: positively_regulates GO:0060576 ! intestinal epithelial cell development

[Term]
id: GO:1905301
name: regulation of macropinocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641]
synonym: "regulation of clathrin-independent pinocytosis" BROAD [GOC:TermGenie]
is_a: GO:0048548 ! regulation of pinocytosis
relationship: regulates GO:0044351 ! macropinocytosis

[Term]
id: GO:1905302
name: negative regulation of macropinocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641]
synonym: "down regulation of macropinocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of macropinocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of macropinocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of macropinocytosis" NARROW [GOC:TermGenie]
is_a: GO:0048550 ! negative regulation of pinocytosis
is_a: GO:1905301 ! regulation of macropinocytosis
relationship: negatively_regulates GO:0044351 ! macropinocytosis

[Term]
id: GO:1905303
name: positive regulation of macropinocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641]
synonym: "activation of macropinocytosis" NARROW [GOC:TermGenie]
synonym: "up regulation of macropinocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of macropinocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of macropinocytosis" EXACT [GOC:TermGenie]
is_a: GO:0048549 ! positive regulation of pinocytosis
is_a: GO:1905301 ! regulation of macropinocytosis
relationship: positively_regulates GO:0044351 ! macropinocytosis

[Term]
id: GO:1905304
name: regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0110020 ! regulation of actomyosin structure organization
is_a: GO:1902115 ! regulation of organelle assembly
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: regulates GO:0055003 ! cardiac myofibril assembly

[Term]
id: GO:1905305
name: negative regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
is_a: GO:1905304 ! regulation of cardiac myofibril assembly
is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation
relationship: negatively_regulates GO:0055003 ! cardiac myofibril assembly

[Term]
id: GO:1905306
name: positive regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie]
synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie]
synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
is_a: GO:1905304 ! regulation of cardiac myofibril assembly
relationship: positively_regulates GO:0055003 ! cardiac myofibril assembly

[Term]
id: GO:1905307
name: response to miconazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1905308
name: cellular response to miconazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1905307 ! response to miconazole

[Term]
id: GO:1905309
name: obsolete positive regulation of cohesin loading
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
synonym: "positive regulation of cohesin association with chromatin" EXACT [GOC:TermGenie]
synonym: "positive regulation of cohesin localization to chromatin" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905310
name: regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis

[Term]
id: GO:1905311
name: negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
synonym: "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: negatively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis

[Term]
id: GO:1905312
name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
synonym: "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: positively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis

[Term]
id: GO:1905313
name: obsolete transforming growth factor beta receptor signaling pathway involved in heart development
namespace: biological_process
def: "OBSOLETE. Any transforming growth factor beta receptor signaling pathway that is involved in heart development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16140292]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "TGF-beta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "TGF-beta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "TGF-beta receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0007179

[Term]
id: GO:1905314
name: semi-lunar valve development
namespace: biological_process
def: "The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19409885]
synonym: "semilunar valve development" EXACT [GOC:TermGenie]
synonym: "semilunar valves development" EXACT [GOC:TermGenie]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:1905315
name: cell proliferation involved in endocardial cushion morphogenesis
namespace: biological_process
def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:1905316
name: superior endocardial cushion morphogenesis
namespace: biological_process
def: "The developmental process by which a superior endocardial cushion is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629]
synonym: "dorsal endocardial cushion morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:1905317
name: inferior endocardial cushion morphogenesis
namespace: biological_process
def: "The developmental process by which an inferior endocardial cushion is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629]
synonym: "ventral endocardial cushion morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:1905318
name: meiosis I spindle assembly checkpoint signaling
namespace: biological_process
def: "Any spindle assembly checkpoint that is involved in meiosis I." [GO_REF:0000060, GOC:TermGenie, PMID:26483559]
synonym: "meiosis I spindle assembly checkpoint" EXACT []
is_a: GO:0033316 ! meiotic spindle assembly checkpoint signaling
is_a: GO:0110029 ! negative regulation of meiosis I

[Term]
id: GO:1905319
name: mesenchymal stem cell migration
namespace: biological_process
def: "The orderly movement of a mesenchymal stem cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:1905320
name: regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:1905319 ! mesenchymal stem cell migration

[Term]
id: GO:1905321
name: negative regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
synonym: "down regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal stem cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1905320 ! regulation of mesenchymal stem cell migration
relationship: negatively_regulates GO:1905319 ! mesenchymal stem cell migration

[Term]
id: GO:1905322
name: positive regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
synonym: "activation of mesenchymal stem cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1905320 ! regulation of mesenchymal stem cell migration
relationship: positively_regulates GO:1905319 ! mesenchymal stem cell migration

[Term]
id: GO:1905323
name: telomerase holoenzyme complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex." [GO_REF:0000079, GOC:TermGenie, PMID:26305931]
synonym: "telomerase holoenzyme complex formation" EXACT [GOC:TermGenie]
is_a: GO:0022618 ! protein-RNA complex assembly

[Term]
id: GO:1905324
name: telomere-telomerase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a telomere-telomerase complex." [GO_REF:0000079, GOC:TermGenie, PMID:26305931]
synonym: "telomere-telomerase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0032200 ! telomere organization

[Term]
id: GO:1905325
name: regulation of meiosis I spindle assembly checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:26483559]
is_a: GO:0060631 ! regulation of meiosis I
is_a: GO:0090231 ! regulation of spindle checkpoint
is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle
relationship: regulates GO:1905318 ! meiosis I spindle assembly checkpoint signaling

[Term]
id: GO:1905326
name: positive regulation of meiosis I spindle assembly checkpoint
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the meiosis I spindle assembly checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:26483559]
synonym: "activation of meiosis I spindle assembly checkpoint" NARROW [GOC:TermGenie]
synonym: "up regulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0090232 ! positive regulation of spindle checkpoint
is_a: GO:1905325 ! regulation of meiosis I spindle assembly checkpoint
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:1905318 ! meiosis I spindle assembly checkpoint signaling

[Term]
id: GO:1905327
name: tracheoesophageal septum formation
namespace: biological_process
def: "The process that gives rise to the tracheoesophageal septum. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:9731532]
synonym: "esophagotracheal septum formation" EXACT [GOC:TermGenie]
synonym: "tracheoesophageal ridges formation" RELATED [GOC:TermGenie]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:1905328
name: plant septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a septum over time, from its formation to the mature structure." [GO_REF:0000080, GOC:tb, GOC:TermGenie, PMID:4562349]
synonym: "dissepiment development" BROAD [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1905329
name: sphingoid long-chain base transport
namespace: biological_process
def: "The directed movement of a sphingoid long-chain base, sometimes referred to as long-chain base, or sphingoid base, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sphingoid long-chain bases are long-chain aliphatic amines that are the fundamental building blocks of sphingolipids. The main mammalian sphingoid long-chain bases are dihydrosphingosine and sphingosine, while dihydrosphingosine and phytosphingosine are the main sphingoid long-chain bases in yeast." [GO_REF:0000065, GOC:rn, GOC:TermGenie, PMID:27136724]
synonym: "dihydrosphingosine transport" NARROW []
synonym: "long-chain base transport" RELATED []
synonym: "phytosphingosine transport" NARROW []
synonym: "sphingoid base(1+) transport" EXACT []
synonym: "sphingoid transport" RELATED []
synonym: "sphingosine transport" NARROW []
is_a: GO:0006869 ! lipid transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:1905330
name: regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:1905331
name: negative regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:1905332
name: positive regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:1905333
name: regulation of gastric motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastric motility." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:9924029]
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0035482 ! gastric motility

[Term]
id: GO:1905334
name: Swi5-Sfr1 complex binding
namespace: molecular_function
def: "Binding to a Swi5-Sfr1 complex." [GOC:TermGenie, PMID:16921379]
synonym: "Sae3-Mei5 complex binding" EXACT [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1905335
name: regulation of aggrephagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]
is_a: GO:0016241 ! regulation of macroautophagy
relationship: regulates GO:0035973 ! aggrephagy

[Term]
id: GO:1905336
name: negative regulation of aggrephagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]
synonym: "down regulation of aggrephagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of aggrephagy" EXACT [GOC:TermGenie]
synonym: "downregulation of aggrephagy" EXACT [GOC:TermGenie]
synonym: "inhibition of aggrephagy" NARROW [GOC:TermGenie]
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:1905335 ! regulation of aggrephagy
relationship: negatively_regulates GO:0035973 ! aggrephagy

[Term]
id: GO:1905337
name: positive regulation of aggrephagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]
synonym: "activation of aggrephagy" NARROW [GOC:TermGenie]
synonym: "up regulation of aggrephagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of aggrephagy" EXACT [GOC:TermGenie]
synonym: "upregulation of aggrephagy" EXACT [GOC:TermGenie]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:1905335 ! regulation of aggrephagy
relationship: positively_regulates GO:0035973 ! aggrephagy

[Term]
id: GO:1905338
name: obsolete negative regulation of cohesin unloading
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term is related to negative regulation of sister chromatid cohesion.
synonym: "down regulation of cohesin unloading" EXACT [GOC:TermGenie]
synonym: "down-regulation of cohesin unloading" EXACT [GOC:TermGenie]
synonym: "downregulation of cohesin unloading" EXACT [GOC:TermGenie]
synonym: "inhibition of cohesin unloading" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905339
name: obsolete positive regulation of cohesin unloading
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
synonym: "activation of cohesin unloading" NARROW [GOC:TermGenie]
synonym: "up regulation of cohesin unloading" EXACT [GOC:TermGenie]
synonym: "up-regulation of cohesin unloading" EXACT [GOC:TermGenie]
synonym: "upregulation of cohesin unloading" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905340
name: regulation of protein localization to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055]
comment: Q9H211 in Human in PMID:22581055
synonym: "regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0034501 ! protein localization to kinetochore

[Term]
id: GO:1905341
name: negative regulation of protein localization to kinetochore
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055]
comment: Q9H211 in Human in PMID:22581055
synonym: "down regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "down regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to kinetochore" EXACT [GOC:TermGenie]
synonym: "down-regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "down-regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to kinetochore" EXACT [GOC:TermGenie]
synonym: "downregulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "downregulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to kinetochore" EXACT [GOC:TermGenie]
synonym: "inhibition of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to kinetochore" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "negative regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905340 ! regulation of protein localization to kinetochore
relationship: negatively_regulates GO:0034501 ! protein localization to kinetochore

[Term]
id: GO:1905342
name: positive regulation of protein localization to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055]
comment: Q9H211 in Human in PMID:22581055
synonym: "activation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to kinetochore" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "positive regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
synonym: "up regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to kinetochore" EXACT [GOC:TermGenie]
synonym: "up-regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to kinetochore" EXACT [GOC:TermGenie]
synonym: "upregulation of condensin localization to kinetochore" NARROW [GOC:TermGenie]
synonym: "upregulation of protein localisation to kinetochore" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to kinetochore" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905340 ! regulation of protein localization to kinetochore
relationship: positively_regulates GO:0034501 ! protein localization to kinetochore

[Term]
id: GO:1905343
name: obsolete regulation of cohesin unloading
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:1905344
name: prostaglandin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prostaglandin." [GO_REF:0000068, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25290914]
synonym: "prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "prostaglandin degradation" EXACT [GOC:TermGenie]
is_a: GO:0062232 ! prostanoid catabolic process

[Term]
id: GO:1905345
name: protein localization to cleavage furrow
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow." [GO_REF:0000087, GOC:TermGenie, PMID:27082518]
synonym: "protein localisation in cleavage furrow" EXACT [GOC:TermGenie]
synonym: "protein localisation to cleavage furrow" EXACT [GOC:TermGenie]
synonym: "protein localization in cleavage furrow" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0072741 ! protein localization to cell division site
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:1905346
name: protein localization to cleavage furrow rim
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow rim." [GO_REF:0000087, GOC:TermGenie, PMID:27082518]
synonym: "protein localisation in cleavage furrow rim" EXACT [GOC:TermGenie]
synonym: "protein localisation to cleavage furrow rim" EXACT [GOC:TermGenie]
synonym: "protein localization in cleavage furrow rim" EXACT [GOC:TermGenie]
is_a: GO:1905345 ! protein localization to cleavage furrow

[Term]
id: GO:1905347
name: endodeoxyribonuclease complex
namespace: cellular_component
def: "A protein complex which is capable of endodeoxyribonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]
comment: An example of this is MUS81 in human (Q96NY9) in PMID:18413719 (inferred from direct assay).
synonym: "Mus81-Eme1 complex" NARROW []
synonym: "Mus81-Eme2 complex" NARROW []
is_a: GO:1905348 ! endonuclease complex

[Term]
id: GO:1905348
name: endonuclease complex
namespace: cellular_component
def: "A protein complex which is capable of endonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]
comment: An example of this is MUS81 in human (Q96NY9) in PMID:18413719 (inferred from direct assay).
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1905349
name: ciliary transition zone assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032]
synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie]
synonym: "cilial transition zone formation" EXACT [GOC:TermGenie]
synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie]
synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie]
synonym: "cilium transition zone formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0060271 ! cilium assembly

[Term]
id: GO:1905350
name: Y-shaped link assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Y-shaped link. Two distinct protein complexes are known to be involved in proper linker assembly: the MKS complex and the NPHP complex. Improper assembly of Y-shaped links may cause malfunctioning of the transition zone as a molecular gate." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:23728985, PMID:24664739, PMID:26595381, PMID:4554367]
synonym: "membrane-microtubule complex assembly" RELATED [GOC:TermGenie]
synonym: "membrane-microtubule complex formation" RELATED [GOC:TermGenie]
synonym: "Y-link assembly" RELATED [GOC:TermGenie]
synonym: "Y-link formation" RELATED [GOC:TermGenie]
synonym: "Y-link structure assembly" RELATED [GOC:TermGenie]
synonym: "Y-link structure formation" RELATED [GOC:TermGenie]
synonym: "Y-shaped assemblage assembly" RELATED [GOC:TermGenie]
synonym: "Y-shaped assemblage formation" RELATED [GOC:TermGenie]
synonym: "Y-shaped fiber assembly" RELATED [GOC:TermGenie]
synonym: "Y-shaped fiber formation" RELATED [GOC:TermGenie]
synonym: "Y-shaped fibre assembly" RELATED [GOC:TermGenie]
synonym: "Y-shaped fibre formation" RELATED [GOC:TermGenie]
synonym: "Y-shaped link formation" EXACT [GOC:TermGenie]
synonym: "Y-shaped linker assembly" RELATED [GOC:TermGenie]
synonym: "Y-shaped linker formation" RELATED [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905351
name: pericyte cell migration
namespace: biological_process
def: "The orderly movement of a pericyte cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26268439]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:1905352
name: ciliary necklace assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary necklace." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:20399632, PMID:6409906]
synonym: "cilial necklace assembly" EXACT [GOC:TermGenie]
synonym: "cilial necklace formation" EXACT [GOC:TermGenie]
synonym: "ciliary necklace formation" EXACT [GOC:TermGenie]
synonym: "cilium necklace assembly" EXACT [GOC:TermGenie]
synonym: "cilium necklace formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905353
name: ciliary transition fiber assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:24189274]
synonym: "centriolar distal appendage assembly" RELATED [GOC:TermGenie]
synonym: "centriolar distal appendage formation" RELATED [GOC:TermGenie]
synonym: "cilial transition fiber assembly" EXACT [GOC:TermGenie]
synonym: "cilial transition fiber formation" EXACT [GOC:TermGenie]
synonym: "cilial transition fibre assembly" EXACT [GOC:TermGenie]
synonym: "cilial transition fibre formation" EXACT [GOC:TermGenie]
synonym: "ciliary transition fiber formation" EXACT [GOC:TermGenie]
synonym: "ciliary transition fibre assembly" EXACT [GOC:TermGenie]
synonym: "ciliary transition fibre formation" EXACT [GOC:TermGenie]
synonym: "cilium transition fiber assembly" EXACT [GOC:TermGenie]
synonym: "cilium transition fiber formation" EXACT [GOC:TermGenie]
synonym: "cilium transition fibre assembly" EXACT [GOC:TermGenie]
synonym: "cilium transition fibre formation" EXACT [GOC:TermGenie]
synonym: "distal appendage of basal body assembly" RELATED [GOC:TermGenie]
synonym: "distal appendage of basal body formation" RELATED [GOC:TermGenie]
synonym: "distal appendage of centriole assembly" RELATED [GOC:TermGenie]
synonym: "distal appendage of centriole formation" RELATED [GOC:TermGenie]
synonym: "distal appendage of mother centriole assembly" RELATED [GOC:TermGenie]
synonym: "distal appendage of mother centriole formation" RELATED [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905354
name: exoribonuclease complex
namespace: cellular_component
def: "A protein complex which is capable of exoribonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17174896]
comment: An example of this is DIS3 in human (Q9Y2L1) in PMID:17174896 (inferred from direct assay).
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1905355
name: spine apparatus assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a spine apparatus." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12928494]
synonym: "dense material assembly" NARROW [GOC:TermGenie]
synonym: "dense material formation" NARROW [GOC:TermGenie]
synonym: "spine apparatus formation" EXACT [GOC:TermGenie]
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:1905356
name: regulation of snRNA pseudouridine synthesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497]
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0031120 ! snRNA pseudouridine synthesis

[Term]
id: GO:1905357
name: negative regulation of snRNA pseudouridine synthesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497]
synonym: "down regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of snRNA pseudouridine synthesis" NARROW [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1905356 ! regulation of snRNA pseudouridine synthesis
relationship: negatively_regulates GO:0031120 ! snRNA pseudouridine synthesis

[Term]
id: GO:1905358
name: positive regulation of snRNA pseudouridine synthesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497]
synonym: "activation of snRNA pseudouridine synthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1905356 ! regulation of snRNA pseudouridine synthesis
relationship: positively_regulates GO:0031120 ! snRNA pseudouridine synthesis

[Term]
id: GO:1905359
name: protein localization to meiotic spindle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle." [GO_REF:0000087, GOC:TermGenie, PMID:26696398]
synonym: "protein localisation to meiotic spindle" EXACT [GOC:TermGenie]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton

[Term]
id: GO:1905360
name: GTPase complex
namespace: cellular_component
def: "A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006]
comment: An example of this is HRAS in human (P01112) in PMID:9178006 (inferred from direct assay).
synonym: "HRAS-SOS1 complex" NARROW []
synonym: "RASH-SOS1 complex" NARROW []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1905362
name: negative regulation of endosomal vesicle fusion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "down regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie]
synonym: "down regulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of endosomal vesicle fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
synonym: "inhibition of endosomal vesicle fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of endosome vesicle fusion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:1905364 ! regulation of endosomal vesicle fusion
relationship: negatively_regulates GO:0034058 ! endosomal vesicle fusion

[Term]
id: GO:1905363
name: positive regulation of endosomal vesicle fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "activation of endosomal vesicle fusion" NARROW [GOC:TermGenie]
synonym: "activation of endosome vesicle fusion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of endosomal vesicle fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:1905364 ! regulation of endosomal vesicle fusion
relationship: positively_regulates GO:0034058 ! endosomal vesicle fusion

[Term]
id: GO:1905364
name: regulation of endosomal vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "regulation of endosome vesicle fusion" EXACT [GOC:TermGenie]
is_a: GO:0031338 ! regulation of vesicle fusion
relationship: regulates GO:0034058 ! endosomal vesicle fusion

[Term]
id: GO:1905365
name: regulation of intralumenal vesicle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "regulation of endosome membrane budding" EXACT [GOC:TermGenie]
is_a: GO:1904978 ! regulation of endosome organization
relationship: regulates GO:0070676 ! intralumenal vesicle formation

[Term]
id: GO:1905366
name: negative regulation of intralumenal vesicle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "down regulation of endosome membrane budding" EXACT [GOC:TermGenie]
synonym: "down regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosome membrane budding" EXACT [GOC:TermGenie]
synonym: "down-regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of endosome membrane budding" EXACT [GOC:TermGenie]
synonym: "downregulation of intralumenal vesicle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of endosome membrane budding" NARROW [GOC:TermGenie]
synonym: "inhibition of intralumenal vesicle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of endosome membrane budding" EXACT [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1904979 ! negative regulation of endosome organization
is_a: GO:1905365 ! regulation of intralumenal vesicle formation
relationship: negatively_regulates GO:0070676 ! intralumenal vesicle formation

[Term]
id: GO:1905367
name: positive regulation of intralumenal vesicle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "activation of endosome membrane budding" NARROW [GOC:TermGenie]
synonym: "activation of intralumenal vesicle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of endosome membrane budding" EXACT [GOC:TermGenie]
synonym: "up regulation of endosome membrane budding" EXACT [GOC:TermGenie]
synonym: "up regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosome membrane budding" EXACT [GOC:TermGenie]
synonym: "up-regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of endosome membrane budding" EXACT [GOC:TermGenie]
synonym: "upregulation of intralumenal vesicle formation" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1904980 ! positive regulation of endosome organization
is_a: GO:1905365 ! regulation of intralumenal vesicle formation
relationship: positively_regulates GO:0070676 ! intralumenal vesicle formation

[Term]
id: GO:1905368
name: peptidase complex
namespace: cellular_component
def: "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]
comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay).
synonym: "protease complex" EXACT []
synonym: "tryptase complex" NARROW []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1905369
name: endopeptidase complex
namespace: cellular_component
def: "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]
comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay).
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:1905370
name: serine-type endopeptidase complex
namespace: cellular_component
def: "A protein complex which is capable of serine-type endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]
comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay).
is_a: GO:1905286 ! serine-type peptidase complex
is_a: GO:1905369 ! endopeptidase complex

[Term]
id: GO:1905371
name: ceramide phosphoethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419]
synonym: "ceramide phosphoethanolamine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:1905372
name: ceramide phosphoethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419]
synonym: "ceramide phosphoethanolamine breakdown" EXACT [GOC:TermGenie]
synonym: "ceramide phosphoethanolamine catabolism" EXACT [GOC:TermGenie]
synonym: "ceramide phosphoethanolamine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process
is_a: GO:1905371 ! ceramide phosphoethanolamine metabolic process

[Term]
id: GO:1905373
name: ceramide phosphoethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419]
synonym: "ceramide phosphoethanolamine anabolism" EXACT [GOC:TermGenie]
synonym: "ceramide phosphoethanolamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "ceramide phosphoethanolamine formation" EXACT [GOC:TermGenie]
synonym: "ceramide phosphoethanolamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:1905371 ! ceramide phosphoethanolamine metabolic process

[Term]
id: GO:1905374
name: response to homocysteine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26722473]
synonym: "response to 2-amino-4-mercaptobutyric acid" EXACT []
synonym: "response to 2-amino-4-sulfanylbutanoic acid" EXACT []
synonym: "response to Hcy" EXACT []
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905375
name: cellular response to homocysteine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26722473]
synonym: "cellular response to 2-amino-4-mercaptobutyric acid" EXACT []
synonym: "cellular response to 2-amino-4-sulfanylbutanoic acid" EXACT []
synonym: "cellular response to Hcy" EXACT []
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905374 ! response to homocysteine

[Term]
id: GO:1905376
name: obsolete negative regulation of cytochrome-c oxidase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26722473]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "down regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "down regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "down regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "down regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "down regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down-regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down-regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down-regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down-regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "down-regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "down-regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "down-regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "down-regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "downregulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "downregulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "downregulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "downregulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "downregulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "downregulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "downregulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "downregulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "downregulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "downregulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "downregulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "inhibition of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "inhibition of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "inhibition of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "inhibition of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "inhibition of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "inhibition of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytochrome c oxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of cytochrome-c oxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "inhibition of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "inhibition of indophenolase" NARROW [GOC:TermGenie]
synonym: "inhibition of NADH cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "inhibition of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "negative regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "negative regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "negative regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "negative regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "negative regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "negative regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "negative regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "negative regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905377
name: response to D-galactose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26261574]
synonym: "response to D-Gal" EXACT []
synonym: "response to D-galacto-hexose" EXACT []
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:1905378
name: cellular response to D-galactose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26261574]
synonym: "cellular response to D-Gal" EXACT []
synonym: "cellular response to D-galacto-hexose" EXACT []
is_a: GO:0071331 ! cellular response to hexose stimulus
is_a: GO:1905377 ! response to D-galactose

[Term]
id: GO:1905379
name: beta-N-acetylhexosaminidase complex
namespace: cellular_component
def: "A protein complex which is capable of beta-N-acetylhexosaminidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:6458607]
comment: An example of this is HEXB in human (UniProt symbol P07686) in PMID:6458607 (inferred from direct assay).
synonym: "HEX A complex" NARROW []
synonym: "HEX B complex" NARROW []
synonym: "HEX S complex" NARROW []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1905380
name: regulation of snRNA transcription by RNA polymerase II
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]
synonym: "regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of snRNA transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II
relationship: regulates GO:0042795 ! snRNA transcription by RNA polymerase II

[Term]
id: GO:1905381
name: negative regulation of snRNA transcription by RNA polymerase II
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]
synonym: "down regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of snRNA transcription from Pol II promoter" NARROW [GOC:TermGenie]
synonym: "inhibition of snRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of snRNA transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II
is_a: GO:1905380 ! regulation of snRNA transcription by RNA polymerase II
relationship: negatively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II

[Term]
id: GO:1905382
name: positive regulation of snRNA transcription by RNA polymerase II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]
comment: An example of this is GTF2A1 in human (UniProt symbol P52655) in PMID:10022900 (inferred from direct assay).
synonym: "activation of snRNA transcription from Pol II promoter" NARROW [GOC:TermGenie]
synonym: "activation of snRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of snRNA transcription from RNA polymerase II promoter" EXACT []
synonym: "up regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II
is_a: GO:1905380 ! regulation of snRNA transcription by RNA polymerase II
relationship: positively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II

[Term]
id: GO:1905383
name: protein localization to presynapse
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494]
synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494]
is_a: GO:0035418 ! protein localization to synapse

[Term]
id: GO:1905384
name: regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1902473 ! regulation of protein localization to synapse
relationship: regulates GO:1905383 ! protein localization to presynapse

[Term]
id: GO:1905385
name: negative regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905384 ! regulation of protein localization to presynapse
relationship: negatively_regulates GO:1905383 ! protein localization to presynapse

[Term]
id: GO:1905386
name: positive regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie]
synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1902474 ! positive regulation of protein localization to synapse
is_a: GO:1905384 ! regulation of protein localization to presynapse
relationship: positively_regulates GO:1905383 ! protein localization to presynapse

[Term]
id: GO:1905387
name: response to beta-carotene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16771696]
synonym: "response to beta,beta-carotene" EXACT []
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:1905388
name: cellular response to beta-carotene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16771696]
synonym: "cellular response to beta,beta-carotene" EXACT []
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1905387 ! response to beta-carotene

[Term]
id: GO:1905389
name: response to leukotriene B4
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14656734]
synonym: "response to LTB4" EXACT []
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:1905390
name: cellular response to leukotriene B4
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14656734]
synonym: "cellular response to LTB4" EXACT []
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:1905389 ! response to leukotriene B4

[Term]
id: GO:1905391
name: regulation of protein localization to cell division site involved in cell separation after cytokinesis
namespace: biological_process
def: "Any regulation of protein localization to cell division site that is involved in cell separation after cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25411334]
synonym: "regulation of protein localisation to cell division site involved in cell separation after cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to cell division site involved in cell separation following cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to cell division site involved in cytokinetic cell separation" RELATED [GOC:TermGenie]
synonym: "regulation of protein localisation to cell division site involved in mitotic cytokinetic cell separation" EXACT [GOC:TermGenie]
is_a: GO:1901900 ! regulation of protein localization to cell division site
relationship: part_of GO:0000920 ! septum digestion after cytokinesis

[Term]
id: GO:1905392
name: plant organ morphogenesis
namespace: biological_process
def: "The developmental process by which a plant organ is generated and organized." [GO_REF:0000083, GOC:tb, GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0099402 ! plant organ development

[Term]
id: GO:1905393
name: plant organ formation
namespace: biological_process
def: "The process that gives rise to the plant organ. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:tb, GOC:TermGenie]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:1905394
name: retromer complex binding
namespace: molecular_function
def: "Binding to a retromer complex." [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27385586]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1905395
name: response to flavonoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905396
name: cellular response to flavonoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905395 ! response to flavonoid

[Term]
id: GO:1905397
name: activated CD8-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an activated CD8-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568]
synonym: "activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070231 ! T cell apoptotic process

[Term]
id: GO:1905398
name: activated CD4-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an activated CD4-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568]
synonym: "activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070231 ! T cell apoptotic process

[Term]
id: GO:1905399
name: regulation of activated CD4-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070232 ! regulation of T cell apoptotic process
relationship: regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process

[Term]
id: GO:1905400
name: negative regulation of activated CD4-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process
relationship: negatively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process

[Term]
id: GO:1905401
name: positive regulation of activated CD4-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "activation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process
relationship: positively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process

[Term]
id: GO:1905402
name: regulation of activated CD8-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070232 ! regulation of T cell apoptotic process
relationship: regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process

[Term]
id: GO:1905403
name: negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process
relationship: negatively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process

[Term]
id: GO:1905404
name: positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "activation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process
relationship: positively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process

[Term]
id: GO:1905405
name: obsolete regulation of mitotic cohesin loading
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:1905406
name: obsolete positive regulation of mitotic cohesin loading
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:1905407
name: regulation of creatine transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585]
subset: gocheck_obsoletion_candidate
is_a: GO:0022898 ! regulation of transmembrane transporter activity

[Term]
id: GO:1905408
name: negative regulation of creatine transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "inhibition of creatine transmembrane transporter activity" NARROW [GOC:TermGenie]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity

[Term]
id: GO:1905409
name: obsolete positive regulation of creatine transmembrane transporter activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of creatine transmembrane transporter activity" NARROW [GOC:TermGenie]
synonym: "up regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905410
name: obsolete regulation of mitotic cohesin unloading
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:1905411
name: obsolete positive regulation of mitotic cohesin unloading
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:1905412
name: obsolete negative regulation of mitotic cohesin loading
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354]
comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
is_obsolete: true

[Term]
id: GO:1905413
name: regulation of dense core granule exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511]
synonym: "regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
relationship: regulates GO:1990504 ! dense core granule exocytosis

[Term]
id: GO:1905414
name: negative regulation of dense core granule exocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of dense core granule exocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core granule exocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of dense core granule exocytosis" NARROW [GOC:TermGenie]
synonym: "inhibition of dense core vesicle exocytosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis
is_a: GO:1905413 ! regulation of dense core granule exocytosis
relationship: negatively_regulates GO:1990504 ! dense core granule exocytosis

[Term]
id: GO:1905415
name: positive regulation of dense core granule exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511]
synonym: "activation of dense core granule exocytosis" NARROW [GOC:TermGenie]
synonym: "activation of dense core vesicle exocytosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core granule exocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core granule exocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie]
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:1905413 ! regulation of dense core granule exocytosis
relationship: positively_regulates GO:1990504 ! dense core granule exocytosis

[Term]
id: GO:1905416
name: regulation of amoeboid sperm motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "regulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "regulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "regulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
is_a: GO:2000145 ! regulation of cell motility
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0097723 ! amoeboid sperm motility

[Term]
id: GO:1905417
name: negative regulation of amoeboid sperm motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "down regulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "down regulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "down regulation of amoeboid sperm motility" EXACT [GOC:TermGenie]
synonym: "down regulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
synonym: "down-regulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "down-regulation of amoeboid sperm motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
synonym: "downregulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "downregulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "downregulation of amoeboid sperm motility" EXACT [GOC:TermGenie]
synonym: "downregulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
synonym: "inhibition of ameboid sperm motility" NARROW [GOC:TermGenie]
synonym: "inhibition of ameboid sperm movement" NARROW [GOC:TermGenie]
synonym: "inhibition of amoeboid sperm motility" NARROW [GOC:TermGenie]
synonym: "inhibition of amoeboid sperm movement" NARROW [GOC:TermGenie]
synonym: "negative regulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "negative regulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "negative regulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
is_a: GO:1905416 ! regulation of amoeboid sperm motility
is_a: GO:2000146 ! negative regulation of cell motility
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0097723 ! amoeboid sperm motility

[Term]
id: GO:1905418
name: positive regulation of amoeboid sperm motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "activation of ameboid sperm motility" NARROW [GOC:TermGenie]
synonym: "activation of ameboid sperm movement" NARROW [GOC:TermGenie]
synonym: "activation of amoeboid sperm motility" NARROW [GOC:TermGenie]
synonym: "activation of amoeboid sperm movement" NARROW [GOC:TermGenie]
synonym: "positive regulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "positive regulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "positive regulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
synonym: "up regulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "up regulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "up regulation of amoeboid sperm motility" EXACT [GOC:TermGenie]
synonym: "up regulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
synonym: "up-regulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "up-regulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "up-regulation of amoeboid sperm motility" EXACT [GOC:TermGenie]
synonym: "up-regulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
synonym: "upregulation of ameboid sperm motility" EXACT [GOC:TermGenie]
synonym: "upregulation of ameboid sperm movement" EXACT [GOC:TermGenie]
synonym: "upregulation of amoeboid sperm motility" EXACT [GOC:TermGenie]
synonym: "upregulation of amoeboid sperm movement" EXACT [GOC:TermGenie]
is_a: GO:1905416 ! regulation of amoeboid sperm motility
is_a: GO:2000147 ! positive regulation of cell motility
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0097723 ! amoeboid sperm motility

[Term]
id: GO:1905420
name: vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any vascular smooth muscle cell differentiation that is involved in phenotypic switching." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT []
synonym: "VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation
is_a: GO:0090679 ! cell differentiation involved in phenotypic switching

[Term]
id: GO:1905421
name: regulation of plant organ morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:1905392 ! plant organ morphogenesis

[Term]
id: GO:1905422
name: negative regulation of plant organ morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie]
synonym: "down regulation of plant organ morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of plant organ morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of plant organ morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of plant organ morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905421 ! regulation of plant organ morphogenesis
relationship: negatively_regulates GO:1905392 ! plant organ morphogenesis

[Term]
id: GO:1905423
name: positive regulation of plant organ morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie]
synonym: "activation of plant organ morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of plant organ morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of plant organ morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of plant organ morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905421 ! regulation of plant organ morphogenesis
relationship: positively_regulates GO:1905392 ! plant organ morphogenesis

[Term]
id: GO:1905424
name: obsolete regulation of Wnt-mediated midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of midbrain dopaminergic neuron differentiation by regulation of Wnt signaling" RELATED [GOC:bf]
synonym: "regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf]
synonym: "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0030111
consider: GO:0071542

[Term]
id: GO:1905425
name: obsolete negative regulation of Wnt-mediated midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "down regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "down regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "down-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "down-regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "downregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "downregulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "inhibition of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "inhibition of Wnt-mediated midbrain DA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of midbrain dopaminergic neuron differentiation by negative regulation of Wnt signaling" RELATED [GOC:bf]
synonym: "negative regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf]
synonym: "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "negative regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "negative regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0030178
consider: GO:1904948

[Term]
id: GO:1905426
name: obsolete positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of Wg signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wg signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wg signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of Wg signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wg signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wg signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of Wnt signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "activation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "activation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "activation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "activation of Wnt-mediated midbrain DA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of midbrain dopaminergic neuron differentiation by positive regulation of Wnt signaling" RELATED [GOC:bf]
synonym: "positive regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf]
synonym: "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "positive regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "positive regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "up regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "up regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "up-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "up-regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "upregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "upregulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0030177
consider: GO:1904948

[Term]
id: GO:1905427
name: obsolete intracellular signal transduction involved in positive regulation of cell growth
namespace: biological_process
def: "OBSOLETE. Any intracellular signal transduction that is involved in positive regulation of cell growth." [GO_REF:0000060, GOC:al, GOC:TermGenie, GOC:vw, PMID:15917811]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "intracellular protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction involved in activation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction involved in stimulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction involved in up regulation of cell growth" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction involved in up-regulation of cell growth" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction involved in upregulation of cell growth" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in activation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in positive regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in stimulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in up regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in up-regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in upregulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling chain involved in activation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signaling chain involved in positive regulation of cell growth" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in stimulation of cell growth" NARROW [GOC:TermGenie]
synonym: "intracellular signaling chain involved in up regulation of cell growth" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in up-regulation of cell growth" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in upregulation of cell growth" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in activation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in positive regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in stimulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in up regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in up-regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in upregulation of cell growth" RELATED [GOC:TermGenie]
synonym: "protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie]
synonym: "protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie]
synonym: "protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in activation of cell growth" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905428
name: regulation of plant organ formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant organ formation." [GO_REF:0000058, GOC:tb, GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:1905393 ! plant organ formation

[Term]
id: GO:1905429
name: response to glycine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164]
synonym: "response to aminoacetic acid" EXACT []
synonym: "response to aminoethanoic acid" EXACT []
synonym: "response to Gly" EXACT []
synonym: "response to glycin" EXACT []
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905430
name: cellular response to glycine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164]
synonym: "cellular response to aminoacetic acid" EXACT []
synonym: "cellular response to aminoethanoic acid" EXACT []
synonym: "cellular response to Gly" EXACT []
synonym: "cellular response to glycin" EXACT []
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905429 ! response to glycine

[Term]
id: GO:1905431
name: microcystin transport
namespace: biological_process
def: "The directed movement of a microcystin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26055554]
is_a: GO:0042886 ! amide transport

[Term]
id: GO:1905432
name: regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0099177 ! regulation of trans-synaptic signaling
relationship: regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide

[Term]
id: GO:1905433
name: negative regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide
relationship: negatively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide

[Term]
id: GO:1905434
name: positive regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide
relationship: positively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide

[Term]
id: GO:1905435
name: obsolete regulation of histone H3-K4 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0042800

[Term]
id: GO:1905436
name: obsolete negative regulation of histone H3-K4 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K4 trimethylation" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905437
name: obsolete positive regulation of histone H3-K4 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3-K4 trimethylation" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905438
name: obsolete non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "OBSOLETE. Any non-canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183]
comment: This term was obsolsted because it represents a GO-CAM model.
synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt-activated signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0035567
consider: GO:0071542

[Term]
id: GO:1905439
name: response to chondroitin 6'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905440
name: cellular response to chondroitin 6'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905439 ! response to chondroitin 6'-sulfate

[Term]
id: GO:1905441
name: response to chondroitin 4'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905442
name: cellular response to chondroitin 4'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905441 ! response to chondroitin 4'-sulfate

[Term]
id: GO:1905443
name: regulation of clathrin coat assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940]
synonym: "regulation of clathrin cage assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0048268 ! clathrin coat assembly

[Term]
id: GO:1905444
name: negative regulation of clathrin coat assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of clathrin cage assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of clathrin coat assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin cage assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin coat assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin cage assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin coat assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin cage assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of clathrin coat assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of clathrin cage assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1905443 ! regulation of clathrin coat assembly
relationship: negatively_regulates GO:0048268 ! clathrin coat assembly

[Term]
id: GO:1905445
name: positive regulation of clathrin coat assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940]
synonym: "activation of clathrin cage assembly" NARROW [GOC:TermGenie]
synonym: "activation of clathrin coat assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of clathrin cage assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of clathrin cage assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of clathrin coat assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of clathrin cage assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of clathrin coat assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of clathrin cage assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of clathrin coat assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1905443 ! regulation of clathrin coat assembly
relationship: positively_regulates GO:0048268 ! clathrin coat assembly

[Term]
id: GO:1905446
name: regulation of mitochondrial ATP synthesis coupled electron transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074]
synonym: "regulation of mitochondrial electron transport" BROAD [GOC:TermGenie]
synonym: "regulation of organelle ATP synthesis coupled electron transport" BROAD [GOC:TermGenie]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:1905447
name: negative regulation of mitochondrial ATP synthesis coupled electron transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074]
synonym: "down regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial ATP synthesis coupled electron transport" NARROW [GOC:TermGenie]
is_a: GO:0090324 ! negative regulation of oxidative phosphorylation
is_a: GO:1905446 ! regulation of mitochondrial ATP synthesis coupled electron transport
relationship: negatively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:1905448
name: positive regulation of mitochondrial ATP synthesis coupled electron transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074]
synonym: "activation of mitochondrial ATP synthesis coupled electron transport" NARROW [GOC:TermGenie]
synonym: "up regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1905446 ! regulation of mitochondrial ATP synthesis coupled electron transport
relationship: positively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:1905449
name: regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707]
synonym: "regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway
relationship: regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis

[Term]
id: GO:1905450
name: negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707]
synonym: "down regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of Fc gamma receptor-dependent phagocytosis" NARROW [GOC:TermGenie]
synonym: "inhibition of Fc-gamma receptor signaling pathway involved in phagocytosis" NARROW [GOC:TermGenie]
synonym: "inhibition of Fc-gamma receptor signalling pathway involved in phagocytosis" NARROW [GOC:TermGenie]
synonym: "inhibition of Fcgamma receptor-mediated phagocytosis" NARROW [GOC:TermGenie]
synonym: "inhibition of IgG-mediated phagocytosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0050765 ! negative regulation of phagocytosis
is_a: GO:1905449 ! regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
relationship: negatively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis

[Term]
id: GO:1905451
name: positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707]
synonym: "activation of Fc gamma receptor-dependent phagocytosis" NARROW [GOC:TermGenie]
synonym: "activation of Fc-gamma receptor signaling pathway involved in phagocytosis" NARROW [GOC:TermGenie]
synonym: "activation of Fc-gamma receptor signalling pathway involved in phagocytosis" NARROW [GOC:TermGenie]
synonym: "activation of Fcgamma receptor-mediated phagocytosis" NARROW [GOC:TermGenie]
synonym: "activation of IgG-mediated phagocytosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:0060369 ! positive regulation of Fc receptor mediated stimulatory signaling pathway
is_a: GO:1905449 ! regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
relationship: positively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis

[Term]
id: GO:1905452
name: obsolete canonical Wnt signaling pathway involved in regulation of stem cell proliferation
namespace: biological_process
def: "OBSOLETE. Any canonical Wnt signaling pathway that is involved in regulation of stem cell proliferation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "canonical Wnt receptor signaling pathway involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in regulation of stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905453
name: regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
relationship: regulates GO:0002318 ! myeloid progenitor cell differentiation

[Term]
id: GO:1905454
name: negative regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation
relationship: negatively_regulates GO:0002318 ! myeloid progenitor cell differentiation

[Term]
id: GO:1905455
name: positive regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation
relationship: positively_regulates GO:0002318 ! myeloid progenitor cell differentiation

[Term]
id: GO:1905456
name: regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
relationship: regulates GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:1905457
name: negative regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "down regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
relationship: negatively_regulates GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:1905458
name: positive regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "activation of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
relationship: positively_regulates GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:1905459
name: regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
relationship: regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process

[Term]
id: GO:1905460
name: negative regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process
is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process
relationship: negatively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process

[Term]
id: GO:1905461
name: positive regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process
is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process
relationship: positively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process

[Term]
id: GO:1905462
name: regulation of DNA duplex unwinding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245]
synonym: "regulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "regulation of duplex DNA melting" EXACT [GOC:TermGenie]
is_a: GO:0033044 ! regulation of chromosome organization
relationship: regulates GO:0032508 ! DNA duplex unwinding

[Term]
id: GO:1905463
name: negative regulation of DNA duplex unwinding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245]
synonym: "down regulation of DNA duplex unwinding" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "down regulation of duplex DNA melting" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA duplex unwinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of duplex DNA melting" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA duplex unwinding" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "downregulation of duplex DNA melting" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA duplex unwinding" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA unwinding" NARROW [GOC:TermGenie]
synonym: "inhibition of duplex DNA melting" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "negative regulation of duplex DNA melting" EXACT [GOC:TermGenie]
is_a: GO:1905462 ! regulation of DNA duplex unwinding
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0032508 ! DNA duplex unwinding

[Term]
id: GO:1905464
name: positive regulation of DNA duplex unwinding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245]
synonym: "activation of DNA duplex unwinding" NARROW [GOC:TermGenie]
synonym: "activation of DNA unwinding" NARROW [GOC:TermGenie]
synonym: "activation of duplex DNA melting" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "positive regulation of duplex DNA melting" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA duplex unwinding" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "up regulation of duplex DNA melting" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA duplex unwinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of duplex DNA melting" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA duplex unwinding" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA unwinding" EXACT [GOC:TermGenie]
synonym: "upregulation of duplex DNA melting" EXACT [GOC:TermGenie]
is_a: GO:1905462 ! regulation of DNA duplex unwinding
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0032508 ! DNA duplex unwinding

[Term]
id: GO:1905465
name: regulation of G-quadruplex DNA unwinding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245]
is_a: GO:0033044 ! regulation of chromosome organization
relationship: regulates GO:0044806 ! G-quadruplex DNA unwinding

[Term]
id: GO:1905466
name: negative regulation of G-quadruplex DNA unwinding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245]
synonym: "down regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie]
synonym: "downregulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie]
synonym: "inhibition of G-quadruplex DNA unwinding" NARROW [GOC:TermGenie]
is_a: GO:1905465 ! regulation of G-quadruplex DNA unwinding
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0044806 ! G-quadruplex DNA unwinding

[Term]
id: GO:1905467
name: positive regulation of G-quadruplex DNA unwinding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245]
synonym: "activation of G-quadruplex DNA unwinding" NARROW [GOC:TermGenie]
synonym: "up regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie]
synonym: "upregulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie]
is_a: GO:1905465 ! regulation of G-quadruplex DNA unwinding
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0044806 ! G-quadruplex DNA unwinding

[Term]
id: GO:1905468
name: obsolete regulation of clathrin-coated pit assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: The reason for obsoletion is this term is describing a process similar to that of regulation of clathrin coat assembly.
synonym: "regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "regulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "regulation of coated pit formation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1905443

[Term]
id: GO:1905469
name: obsolete negative regulation of clathrin-coated pit assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
comment: The reason for obsoletion is this term is describing a process similar to that of negative regulation of clathrin coat assembly.
synonym: "down regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "down regulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of coated pit formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of coated pit formation" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "downregulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of coated pit formation" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin-coated pit assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of clathrin-coated pit formation" NARROW [GOC:TermGenie]
synonym: "inhibition of coated pit assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of coated pit formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of coated pit formation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1905444

[Term]
id: GO:1905470
name: obsolete positive regulation of clathrin-coated pit assembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
comment: The reason for obsoletion is this term is describing a process similar to that of positive regulation of clathrin coat assembly.
synonym: "activation of clathrin-coated pit assembly" NARROW [GOC:TermGenie]
synonym: "activation of clathrin-coated pit formation" NARROW [GOC:TermGenie]
synonym: "activation of coated pit assembly" NARROW [GOC:TermGenie]
synonym: "activation of coated pit formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of coated pit formation" EXACT [GOC:TermGenie]
synonym: "up regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "up regulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of coated pit formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of coated pit formation" EXACT [GOC:TermGenie]
synonym: "upregulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of clathrin-coated pit formation" EXACT [GOC:TermGenie]
synonym: "upregulation of coated pit assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of coated pit formation" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1905445

[Term]
id: GO:1905471
name: obsolete regulation of histone H3-K79 dimethylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139]
comment: This term was obsoleted because it represents regulation of a molecular function.
synonym: "regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905472
name: obsolete negative regulation of histone H3-K79 dimethylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139]
comment: This term was obsoleted because it represents regulation of a molecular function.
synonym: "down regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3 K79 dimethylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone H3-K79 dimethylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone lysine H3 K79 dimethylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905473
name: obsolete positive regulation of histone H3-K79 dimethylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of histone H3 K79 dimethylation" NARROW [GOC:TermGenie]
synonym: "activation of histone H3-K79 dimethylation" NARROW [GOC:TermGenie]
synonym: "activation of histone lysine H3 K79 dimethylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0140673

[Term]
id: GO:1905474
name: obsolete canonical Wnt signaling pathway involved in stem cell proliferation
namespace: biological_process
def: "OBSOLETE. Any canonical Wnt signaling pathway that is involved in stem cell proliferation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "canonical Wnt receptor signaling pathway involved in stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0060070
consider: GO:0072089

[Term]
id: GO:1905475
name: regulation of protein localization to membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0072657 ! protein localization to membrane

[Term]
id: GO:1905476
name: negative regulation of protein localization to membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: negatively_regulates GO:0072657 ! protein localization to membrane

[Term]
id: GO:1905477
name: positive regulation of protein localization to membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905475 ! regulation of protein localization to membrane
relationship: positively_regulates GO:0072657 ! protein localization to membrane

[Term]
id: GO:1905478
name: obsolete regulation of glutamate-ammonia ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905479
name: obsolete negative regulation of glutamate-ammonia ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate-ammonia ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glutamine synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glutamylhydroxamic synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamate:ammonia ligase (ADP-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamine synthetase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905480
name: obsolete positive regulation of glutamate-ammonia ligase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of glutamate-ammonia ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of glutamine synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of glutamylhydroxamic synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamate:ammonia ligase (ADP-forming)" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamine synthetase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamine synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905481
name: obsolete cytoplasmic sequestering of protein involved in mitotic DNA replication checkpoint
namespace: biological_process
def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic DNA replication checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1905482
name: obsolete cytoplasmic sequestering of protein involved in G2 DNA damage checkpoint
namespace: biological_process
def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in G2 DNA damage checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1905483
name: regulation of motor neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
is_a: GO:2001222 ! regulation of neuron migration
relationship: regulates GO:0097475 ! motor neuron migration

[Term]
id: GO:1905484
name: negative regulation of motor neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "down regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "downregulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "inhibition of motor neuron migration" NARROW [GOC:TermGenie]
is_a: GO:1905483 ! regulation of motor neuron migration
is_a: GO:2001223 ! negative regulation of neuron migration
relationship: negatively_regulates GO:0097475 ! motor neuron migration

[Term]
id: GO:1905485
name: positive regulation of motor neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of motor neuron migration" NARROW [GOC:TermGenie]
synonym: "up regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "upregulation of motor neuron migration" EXACT [GOC:TermGenie]
is_a: GO:1905483 ! regulation of motor neuron migration
is_a: GO:2001224 ! positive regulation of neuron migration
relationship: positively_regulates GO:0097475 ! motor neuron migration

[Term]
id: GO:1905486
name: regulation of anterior/posterior axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:1902667 ! regulation of axon guidance
relationship: regulates GO:0033564 ! anterior/posterior axon guidance

[Term]
id: GO:1905487
name: negative regulation of anterior/posterior axon guidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "down regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
synonym: "downregulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
synonym: "inhibition of anterior-posterior axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of anterior/posterior axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of anterior/posterior axon pathfinding" NARROW [GOC:TermGenie]
synonym: "negative regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "negative regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:1902668 ! negative regulation of axon guidance
is_a: GO:1905486 ! regulation of anterior/posterior axon guidance
relationship: negatively_regulates GO:0033564 ! anterior/posterior axon guidance

[Term]
id: GO:1905488
name: positive regulation of anterior/posterior axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of anterior-posterior axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of anterior/posterior axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of anterior/posterior axon pathfinding" NARROW [GOC:TermGenie]
synonym: "positive regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "positive regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
synonym: "upregulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:1902669 ! positive regulation of axon guidance
is_a: GO:1905486 ! regulation of anterior/posterior axon guidance
relationship: positively_regulates GO:0033564 ! anterior/posterior axon guidance

[Term]
id: GO:1905489
name: regulation of sensory neuron axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
is_a: GO:1902667 ! regulation of axon guidance
relationship: regulates GO:0097374 ! sensory neuron axon guidance

[Term]
id: GO:1905490
name: negative regulation of sensory neuron axon guidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "down regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "inhibition of sensory neuron axon guidance" NARROW [GOC:TermGenie]
is_a: GO:1902668 ! negative regulation of axon guidance
is_a: GO:1905489 ! regulation of sensory neuron axon guidance
relationship: negatively_regulates GO:0097374 ! sensory neuron axon guidance

[Term]
id: GO:1905491
name: positive regulation of sensory neuron axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of sensory neuron axon guidance" NARROW [GOC:TermGenie]
synonym: "up regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory neuron axon guidance" EXACT [GOC:TermGenie]
is_a: GO:1902669 ! positive regulation of axon guidance
is_a: GO:1905489 ! regulation of sensory neuron axon guidance
relationship: positively_regulates GO:0097374 ! sensory neuron axon guidance

[Term]
id: GO:1905492
name: positive regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie]
synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve
relationship: positively_regulates GO:0048755 ! branching morphogenesis of a nerve

[Term]
id: GO:1905493
name: regulation of G-quadruplex DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of G quartet binding" BROAD [GOC:TermGenie]
synonym: "regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of G-quartet binding" BROAD [GOC:TermGenie]
synonym: "regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:1905494
name: negative regulation of G-quadruplex DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "down regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of G quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G-DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G-quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G-quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of tetraplex DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1905493 ! regulation of G-quadruplex DNA binding

[Term]
id: GO:1905495
name: positive regulation of G-quadruplex DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "activation of G quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G-DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G-quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G-quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of tetraplex DNA binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1905493 ! regulation of G-quadruplex DNA binding

[Term]
id: GO:1905496
name: regulation of triplex DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:1905497
name: negative regulation of triplex DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "down regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of triplex DNA binding" NARROW [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1905496 ! regulation of triplex DNA binding

[Term]
id: GO:1905498
name: positive regulation of triplex DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "activation of triplex DNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of triplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1905496 ! regulation of triplex DNA binding

[Term]
id: GO:1905499
name: trichome papilla formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a trichome papilla." [GO_REF:0000079, GOC:tb, GOC:TermGenie, PMID:24014871]
synonym: "trichome papilla assembly" RELATED []
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0010090 ! trichome morphogenesis

[Term]
id: GO:1905500
name: obsolete heteroreceptor complex assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a heteroreceptor complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24157794]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "heteroreceptor complex formation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905501
name: obsolete heteroreceptor complex disassembly
namespace: biological_process
def: "OBSOLETE. The disaggregation of a heteroreceptor complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24157794]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1905502
name: acetyl-CoA binding
namespace: molecular_function
def: "Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component." [GO_REF:0000067, GOC:bc, GOC:krc, GOC:PARL, GOC:TermGenie, PMID:24927529]
synonym: "acetyl-coenzyme A binding" EXACT []
is_a: GO:0120227 ! acyl-CoA binding

[Term]
id: GO:1905503
name: regulation of motile cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "regulation of motile primary cilium assembly" RELATED []
synonym: "regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "regulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:1902017 ! regulation of cilium assembly
relationship: regulates GO:0044458 ! motile cilium assembly

[Term]
id: GO:1905504
name: negative regulation of motile cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "down regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "down regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "downregulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "inhibition of motile primary cilia assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilia formation" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilium formation" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilium assembly" RELATED []
synonym: "negative regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:1902018 ! negative regulation of cilium assembly
is_a: GO:1905503 ! regulation of motile cilium assembly
relationship: negatively_regulates GO:0044458 ! motile cilium assembly

[Term]
id: GO:1905505
name: positive regulation of motile cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "activation of motile primary cilia assembly" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilia formation" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilium formation" NARROW [GOC:TermGenie]
synonym: "activation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "activation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilium assembly" RELATED []
synonym: "positive regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "up regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "upregulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:0045724 ! positive regulation of cilium assembly
is_a: GO:1905503 ! regulation of motile cilium assembly
relationship: positively_regulates GO:0044458 ! motile cilium assembly

[Term]
id: GO:1905506
name: gerontoplast stroma
namespace: cellular_component
def: "Any plastid stroma that is part of a gerontoplast." [GO_REF:0000064, GOC:mag, GOC:TermGenie, PMID:11212360]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0034400 ! gerontoplast

[Term]
id: GO:1905507
name: obsolete cytoplasmic sequestering of protein involved in mitotic G2 DNA damage checkpoint
namespace: biological_process
def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic G2 DNA damage checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:1905508
name: protein localization to microtubule organizing center
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497]
synonym: "protein localisation in microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localisation to microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localization in microtubule organizing center" EXACT [GOC:TermGenie]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton

[Term]
id: GO:1905509
name: protein localization to interphase microtubule organizing center
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an interphase microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497]
synonym: "protein localisation in interphase microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localisation to interphase microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localization in interphase microtubule organizing center" EXACT [GOC:TermGenie]
is_a: GO:1905508 ! protein localization to microtubule organizing center

[Term]
id: GO:1905510
name: negative regulation of myosin II filament assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416]
comment: positive regulation / down regulation of the formation of a bipolar filament composed of myosin II molecules
synonym: "down regulation of myosin II filament assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "down-regulation of myosin II filament assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "downregulation of myosin II filament assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "inhibition of myosin II filament assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "negative regulation of myosin II polymerization" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0043520 ! regulation of myosin II filament assembly
is_a: GO:1904900 ! negative regulation of myosin II filament organization
relationship: negatively_regulates GO:0031036 ! myosin II filament assembly

[Term]
id: GO:1905511
name: positive regulation of myosin II filament assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myosin II filament assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416]
comment: positive regulation / down regulation of the formation of a bipolar filament composed of myosin II molecules
synonym: "activation of myosin II filament assembly" NARROW [GOC:TermGenie]
synonym: "activation of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "positive regulation of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "up regulation of myosin II filament assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "up-regulation of myosin II filament assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of myosin II polymerization" RELATED [GOC:TermGenie]
synonym: "upregulation of myosin II filament assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of myosin II polymerization" RELATED [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0043520 ! regulation of myosin II filament assembly
is_a: GO:1904901 ! positive regulation of myosin II filament organization
relationship: positively_regulates GO:0031036 ! myosin II filament assembly

[Term]
id: GO:1905512
name: regulation of short-term synaptic potentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145]
synonym: "regulation of synaptic facilitation" EXACT [GOC:TermGenie]
is_a: GO:0048167 ! regulation of synaptic plasticity
relationship: regulates GO:1990926 ! short-term synaptic potentiation

[Term]
id: GO:1905513
name: negative regulation of short-term synaptic potentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145]
synonym: "down regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic facilitation" EXACT [GOC:TermGenie]
synonym: "down-regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic facilitation" EXACT [GOC:TermGenie]
synonym: "downregulation of short-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic facilitation" EXACT [GOC:TermGenie]
synonym: "inhibition of short-term synaptic potentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic facilitation" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic facilitation" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1905512 ! regulation of short-term synaptic potentiation
relationship: negatively_regulates GO:1990926 ! short-term synaptic potentiation

[Term]
id: GO:1905514
name: positive regulation of short-term synaptic potentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145]
synonym: "activation of short-term synaptic potentiation" NARROW [GOC:TermGenie]
synonym: "activation of synaptic facilitation" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic facilitation" EXACT [GOC:TermGenie]
synonym: "up regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic facilitation" EXACT [GOC:TermGenie]
synonym: "up-regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic facilitation" EXACT [GOC:TermGenie]
synonym: "upregulation of short-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic facilitation" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1905512 ! regulation of short-term synaptic potentiation
relationship: positively_regulates GO:1990926 ! short-term synaptic potentiation

[Term]
id: GO:1905515
name: non-motile cilium assembly
namespace: biological_process
alt_id: GO:0035058
def: "The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]
synonym: "immotile primary cilium assembly" RELATED [GOC:bf]
synonym: "non-motile cilium formation" EXACT [GOC:TermGenie]
synonym: "nonmotile cilium assembly" EXACT [GOC:TermGenie]
synonym: "nonmotile cilium formation" EXACT [GOC:TermGenie]
synonym: "nonmotile primary cilia assembly" RELATED [GOC:bf]
synonym: "nonmotile primary cilium assembly" RELATED []
synonym: "sensory cilium assembly" RELATED [GOC:kmv]
synonym: "sensory cilium biogenesis" RELATED [GOC:mah]
is_a: GO:0060271 ! cilium assembly

[Term]
id: GO:1905516
name: positive regulation of fertilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576]
synonym: "activation of fertilization" NARROW [GOC:TermGenie]
synonym: "activation of syngamy" NARROW [GOC:TermGenie]
synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "up regulation of fertilization" EXACT [GOC:TermGenie]
synonym: "up regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "upregulation of fertilization" EXACT [GOC:TermGenie]
synonym: "upregulation of syngamy" EXACT [GOC:TermGenie]
is_a: GO:0080154 ! regulation of fertilization
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0009566 ! fertilization

[Term]
id: GO:1905517
name: macrophage migration
namespace: biological_process
def: "The orderly movement of a macrophage from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:25749876]
is_a: GO:0071674 ! mononuclear cell migration
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:1905518
name: regulation of presynaptic active zone assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875]
synonym: "regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "regulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:1904071 ! presynaptic active zone assembly

[Term]
id: GO:1905519
name: negative regulation of presynaptic active zone assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875]
synonym: "down regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "down regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "downregulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "downregulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "inhibition of pre-synaptic active zone assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "inhibition of pre-synaptic active zone formation" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic active zone assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic active zone formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
is_a: GO:1905518 ! regulation of presynaptic active zone assembly
is_a: GO:1905607 ! negative regulation of presynapse assembly
relationship: negatively_regulates GO:1904071 ! presynaptic active zone assembly

[Term]
id: GO:1905520
name: positive regulation of presynaptic active zone assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875]
synonym: "activation of pre-synaptic active zone assembly" NARROW [GOC:TermGenie]
synonym: "activation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "activation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "activation of pre-synaptic active zone formation" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic active zone assembly" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic active zone formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "up regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "up regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "upregulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "upregulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic active zone formation" EXACT [GOC:TermGenie]
is_a: GO:1905518 ! regulation of presynaptic active zone assembly
is_a: GO:1905608 ! positive regulation of presynapse assembly
relationship: positively_regulates GO:1904071 ! presynaptic active zone assembly

[Term]
id: GO:1905521
name: regulation of macrophage migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: regulates GO:1905517 ! macrophage migration

[Term]
id: GO:1905522
name: negative regulation of macrophage migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
synonym: "down regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "inhibition of macrophage migration" NARROW [GOC:TermGenie]
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:1905521 ! regulation of macrophage migration
relationship: negatively_regulates GO:1905517 ! macrophage migration

[Term]
id: GO:1905523
name: positive regulation of macrophage migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
synonym: "activation of macrophage migration" NARROW [GOC:TermGenie]
synonym: "up regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage migration" EXACT [GOC:TermGenie]
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:1905521 ! regulation of macrophage migration
relationship: positively_regulates GO:1905517 ! macrophage migration

[Term]
id: GO:1905524
name: negative regulation of protein autoubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:17237821]
synonym: "down regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein auto-ubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of protein auto-ubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein autoubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of protein autoubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein self-ubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of protein self-ubiquitinylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:1902498 ! regulation of protein autoubiquitination
relationship: negatively_regulates GO:0051865 ! protein autoubiquitination

[Term]
id: GO:1905525
name: obsolete regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter in response to iron that results in regulation of ferrichrome biosynthetic process." [GO_REF:0000063, GOC:TermGenie, PMID:20435771]
comment: This term was made obsolete because it was added in error.
synonym: "regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905526
name: regulation of Golgi lumen acidification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592]
is_a: GO:0032847 ! regulation of cellular pH reduction
relationship: regulates GO:0061795 ! Golgi lumen acidification

[Term]
id: GO:1905527
name: negative regulation of Golgi lumen acidification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592]
synonym: "down regulation of Golgi lumen acidification" EXACT [GOC:TermGenie]
synonym: "down-regulation of Golgi lumen acidification" EXACT [GOC:TermGenie]
synonym: "downregulation of Golgi lumen acidification" EXACT [GOC:TermGenie]
synonym: "inhibition of Golgi lumen acidification" NARROW [GOC:TermGenie]
is_a: GO:0032848 ! negative regulation of cellular pH reduction
is_a: GO:1905526 ! regulation of Golgi lumen acidification
relationship: negatively_regulates GO:0061795 ! Golgi lumen acidification

[Term]
id: GO:1905528
name: positive regulation of Golgi lumen acidification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592]
synonym: "activation of Golgi lumen acidification" NARROW [GOC:TermGenie]
synonym: "up regulation of Golgi lumen acidification" EXACT [GOC:TermGenie]
synonym: "up-regulation of Golgi lumen acidification" EXACT [GOC:TermGenie]
synonym: "upregulation of Golgi lumen acidification" EXACT [GOC:TermGenie]
is_a: GO:0032849 ! positive regulation of cellular pH reduction
is_a: GO:1905526 ! regulation of Golgi lumen acidification
relationship: positively_regulates GO:0061795 ! Golgi lumen acidification

[Term]
id: GO:1905529
name: regulation of uracil import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126]
is_a: GO:0034762 ! regulation of transmembrane transport
relationship: regulates GO:0098721 ! uracil import across plasma membrane

[Term]
id: GO:1905530
name: negative regulation of uracil import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1905529 ! regulation of uracil import across plasma membrane
relationship: negatively_regulates GO:0098721 ! uracil import across plasma membrane

[Term]
id: GO:1905531
name: positive regulation of uracil import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1905529 ! regulation of uracil import across plasma membrane
relationship: positively_regulates GO:0098721 ! uracil import across plasma membrane

[Term]
id: GO:1905532
name: regulation of L-leucine import across plasma membrane
namespace: biological_process
alt_id: GO:1903128
def: "Any process that modulates the frequency, rate or extent of L-leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003]
synonym: "regulation of L-leucine import into cell" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:1903801 ! L-leucine import across plasma membrane

[Term]
id: GO:1905533
name: negative regulation of L-leucine import across plasma membrane
namespace: biological_process
alt_id: GO:1903129
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003]
synonym: "down regulation of L-leucine import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-leucine import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of L-leucine import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of leucine import into cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-leucine import into cell" EXACT []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1905532 ! regulation of L-leucine import across plasma membrane
relationship: negatively_regulates GO:1903801 ! L-leucine import across plasma membrane

[Term]
id: GO:1905534
name: positive regulation of L-leucine import across plasma membrane
namespace: biological_process
alt_id: GO:1903130
def: "Any process that activates or increases the frequency, rate or extent of L-leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003]
synonym: "activation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "activation of leucine import into cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-leucine import into cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucine import across plasma membrane" BROAD []
synonym: "up regulation of L-leucine import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of L-leucine import into cell" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1905532 ! regulation of L-leucine import across plasma membrane
relationship: positively_regulates GO:1903801 ! L-leucine import across plasma membrane

[Term]
id: GO:1905535
name: regulation of eukaryotic translation initiation factor 4F complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
synonym: "regulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "regulation of eIF4F assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly

[Term]
id: GO:1905536
name: negative regulation of eukaryotic translation initiation factor 4F complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
synonym: "down regulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of eIF4F assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of eIF4F assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of eIF4F assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of eIF-4F assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of eIF4F assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of eukaryotic translation initiation factor 4F complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of eIF4F assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1905535 ! regulation of eukaryotic translation initiation factor 4F complex assembly
relationship: negatively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly

[Term]
id: GO:1905537
name: positive regulation of eukaryotic translation initiation factor 4F complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
synonym: "activation of eIF-4F assembly" NARROW [GOC:TermGenie]
synonym: "activation of eIF4F assembly" NARROW [GOC:TermGenie]
synonym: "activation of eukaryotic translation initiation factor 4F complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of eIF4F assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of eIF4F assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of eIF4F assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of eIF-4F assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of eIF4F assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1905535 ! regulation of eukaryotic translation initiation factor 4F complex assembly
relationship: positively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly

[Term]
id: GO:1905538
name: obsolete polysome binding
namespace: molecular_function
def: "OBSOLETE. Binding to a polysome." [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
comment: This term is outside the scope of GO.
synonym: "polyribosome binding" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0043022

[Term]
id: GO:1905539
name: regulation of postsynapse to nucleus signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway." [GO_REF:0000058, GOC:TermGenie, ISBN:9780071120005]
subset: goslim_synapse
synonym: "regulation of postsynaptic signaling to nucleus" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0099527 ! postsynapse to nucleus signaling pathway

[Term]
id: GO:1905540
name: interleukin-7 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-7 (IL-7) and that consists of, at a minimum, an interleukin, an alpha and a gamma chain as well as optional additional kinase subunits. The alpha chain binds IL-7 with high affinity and subsequently binds the cytokine receptor common gamma chain that forms part of multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:19141282]
comment: An example of this is IL7R in human (P16871) in PMID:19141282 (inferred from direct assay).
synonym: "IL-7 receptor complex" EXACT []
synonym: "IL-7-receptor complex" EXACT []
synonym: "IL7 receptor complex" EXACT []
synonym: "IL7-receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:1905541
name: regulation of L-arginine import across plasma membrane
namespace: biological_process
alt_id: GO:0010963
alt_id: GO:1902826
def: "Any process that modulates the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525]
synonym: "regulation of L-arginine import" BROAD []
synonym: "regulation of L-arginine import into cell" EXACT []
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:0097638 ! L-arginine import across plasma membrane

[Term]
id: GO:1905542
name: negative regulation of L-arginine import across plasma membrane
namespace: biological_process
alt_id: GO:1902827
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525]
synonym: "down regulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of L-arginine import into cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-arginine import into cell" EXACT []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane
relationship: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane

[Term]
id: GO:1905543
name: interleukin-15 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-15 (IL-15) and that consists of, at a minimum, an interleukin, an alpha, beta and gamma chain as well as optional additional kinase subunits. The alpha chain is unique to binds IL-15 while it shares the beta chain with the IL-2 receptor and the cytokine receptor common gamma chain with multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23104097]
comment: An example of this is IL15RA in human (Q13261) in PMID:23104097 (inferred from physical interaction).
synonym: "IL-15 receptor complex" EXACT []
synonym: "IL-15-receptor complex" EXACT []
synonym: "IL15 receptor complex" EXACT []
synonym: "IL15-receptor complex" EXACT []
synonym: "interleukin-15-receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:1905544
name: L-methionine import across plasma membrane
namespace: biological_process
alt_id: GO:1903813
def: "The directed movement of L-methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368]
synonym: "L-methionine import into cell" EXACT []
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903692 ! methionine import across plasma membrane

[Term]
id: GO:1905545
name: obsolete negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron." [GO_REF:0000058, GOC:TermGenie, PMID:20435771]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905546
name: cellular response to phenylpropanoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylpropanoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080184 ! response to phenylpropanoid

[Term]
id: GO:1905547
name: obsolete regulation of subtelomeric heterochromatin assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of subtelomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580]
comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
synonym: "regulation of telomeric heterochromatin assembly" RELATED []
synonym: "regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905548
name: obsolete negative regulation of subtelomeric heterochromatin assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of subtelomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580]
comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
synonym: "down regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
synonym: "downregulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
synonym: "inhibition of telomeric heterochromatin assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric heterochromatin formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomeric heterochromatin assembly" RELATED []
synonym: "negative regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905549
name: obsolete positive regulation of subtelomeric heterochromatin assembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of subtelomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580]
comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
synonym: "activation of telomeric heterochromatin assembly" NARROW [GOC:TermGenie]
synonym: "activation of telomeric heterochromatin formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomeric heterochromatin assembly" RELATED []
synonym: "positive regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
synonym: "up regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
synonym: "upregulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905550
name: regulation of protein localization to endoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340]
synonym: "regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in ER" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0070972 ! protein localization to endoplasmic reticulum

[Term]
id: GO:1905551
name: negative regulation of protein localization to endoplasmic reticulum
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340]
synonym: "down regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in ER" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in ER" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in ER" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in endoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in endoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in ER" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to endoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in ER" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905550 ! regulation of protein localization to endoplasmic reticulum
relationship: negatively_regulates GO:0070972 ! protein localization to endoplasmic reticulum

[Term]
id: GO:1905552
name: positive regulation of protein localization to endoplasmic reticulum
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340]
synonym: "activation of protein localisation in endoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in endoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in ER" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to endoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in ER" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in ER" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in ER" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in ER" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905550 ! regulation of protein localization to endoplasmic reticulum
relationship: positively_regulates GO:0070972 ! protein localization to endoplasmic reticulum

[Term]
id: GO:1905553
name: regulation of blood vessel branching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
relationship: regulates GO:0001569 ! branching involved in blood vessel morphogenesis

[Term]
id: GO:1905554
name: negative regulation of vessel branching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
is_a: GO:1905553 ! regulation of blood vessel branching
relationship: negatively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis

[Term]
id: GO:1905555
name: positive regulation of blood vessel branching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie]
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
is_a: GO:1905553 ! regulation of blood vessel branching
relationship: positively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis

[Term]
id: GO:1905556
name: ciliary vesicle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary vesicle. Multiple smaller vesicles dock to the transitional fibers on a mature basal body and then fuse together to form a larger single vesicle. This then fuses with the plasma membrane and forms the ciliary membrane." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:13978319, PMID:25313408, PMID:25805133, PMID:25812525]
synonym: "ciliary vesicle formation" EXACT [GOC:TermGenie]
synonym: "CV assembly" RELATED [GOC:TermGenie]
synonym: "CV formation" RELATED [GOC:TermGenie]
synonym: "primary ciliary vesicle assembly" EXACT [GOC:TermGenie]
synonym: "primary ciliary vesicle formation" EXACT [GOC:TermGenie]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:1905557
name: regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
is_a: GO:0010549 ! regulation of membrane disassembly
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0007077 ! mitotic nuclear membrane disassembly

[Term]
id: GO:1905558
name: negative regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly
relationship: negatively_regulates GO:0007077 ! mitotic nuclear membrane disassembly

[Term]
id: GO:1905559
name: positive regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly
relationship: positively_regulates GO:0007077 ! mitotic nuclear membrane disassembly

[Term]
id: GO:1905560
name: negative regulation of kinetochore assembly
namespace: biological_process
alt_id: GO:1901720
def: "Any process that stops, prevents or reduces the frequency, rate or extent of kinetochore assembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "down regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "down regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "down regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "down regulation of kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of kinetochore biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "down-regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "down-regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "down-regulation of kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "downregulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "downregulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "downregulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "downregulation of kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "inhibition of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "inhibition of kinetochore assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "negative regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "negative regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "negative regulation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of NMS complex assembly" NARROW []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0090234 ! regulation of kinetochore assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:2001251 ! negative regulation of chromosome organization
relationship: negatively_regulates GO:0051382 ! kinetochore assembly

[Term]
id: GO:1905561
name: positive regulation of kinetochore assembly
namespace: biological_process
alt_id: GO:1901721
def: "Any process that activates or increases the frequency, rate or extent of kinetochore assembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "activation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "activation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "activation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "activation of kinetochore assembly" NARROW [GOC:TermGenie]
synonym: "activation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "positive regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "positive regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "positive regulation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of NMS complex assembly" NARROW []
synonym: "up regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "up regulation of kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "up-regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "up-regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "up-regulation of kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of kinetochore formation" RELATED [GOC:TermGenie]
synonym: "upregulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "upregulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "upregulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "upregulation of kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of kinetochore formation" RELATED [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0090234 ! regulation of kinetochore assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0051382 ! kinetochore assembly

[Term]
id: GO:1905562
name: regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
is_a: GO:0001936 ! regulation of endothelial cell proliferation
relationship: regulates GO:0101023 ! vascular endothelial cell proliferation

[Term]
id: GO:1905563
name: negative regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0001937 ! negative regulation of endothelial cell proliferation
is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation
relationship: negatively_regulates GO:0101023 ! vascular endothelial cell proliferation

[Term]
id: GO:1905564
name: positive regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0001938 ! positive regulation of endothelial cell proliferation
is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation
relationship: positively_regulates GO:0101023 ! vascular endothelial cell proliferation

[Term]
id: GO:1905565
name: obsolete regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905566
name: obsolete negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905567
name: obsolete positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie]
synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905568
name: regulation of ferrichrome biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie]
synonym: "regulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "regulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "regulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
relationship: regulates GO:0031169 ! ferrichrome biosynthetic process

[Term]
id: GO:1905569
name: negative regulation of ferrichrome biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321]
synonym: "down regulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down regulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "downregulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "downregulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ferrichrome anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrichrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrichrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrichrome formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrichrome synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:1900705 ! negative regulation of siderophore biosynthetic process
is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process
relationship: negatively_regulates GO:0031169 ! ferrichrome biosynthetic process

[Term]
id: GO:1905570
name: positive regulation of ferrichrome biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321]
synonym: "activation of ferrichrome anabolism" NARROW [GOC:TermGenie]
synonym: "activation of ferrichrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of ferrichrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "activation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "activation of ferrichrome formation" NARROW [GOC:TermGenie]
synonym: "activation of ferrichrome synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrichrome anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "upregulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "upregulation of ferrichrome formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrichrome synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:1900706 ! positive regulation of siderophore biosynthetic process
is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process
relationship: positively_regulates GO:0031169 ! ferrichrome biosynthetic process

[Term]
id: GO:1905571
name: interleukin-10 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-10 (IL-10) and that consists of, at a minimum, a dimeric interleukin, an alpha and a beta chain as well as optional additional kinase subunits. The alpha chain binds IL-10 with high affinity and subsequently binds the common beta receptor chain that forms part of multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16982608]
comment: An example of this is IL10RA in human (UniProt symbol Q13651) in PMID:16982608 (inferred from physical interaction).
synonym: "IL-10 receptor complex" EXACT []
synonym: "IL-10-receptor complex" EXACT []
synonym: "IL10 receptor complex" EXACT []
synonym: "interleukin-10-receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:1905572
name: ganglioside GM1 transport to membrane
namespace: biological_process
def: "The directed movement of ganglioside GM1 to membrane." [GO_REF:0000078, GOC:TermGenie, PMID:1454804]
is_a: GO:0035627 ! ceramide transport
is_a: GO:0046836 ! glycolipid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:1905573
name: ganglioside GM1 binding
namespace: molecular_function
def: "Binding to ganglioside GM1." [GO_REF:0000067, GOC:TermGenie, PMID:1454804]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0035594 ! ganglioside binding

[Term]
id: GO:1905574
name: ganglioside GM2 binding
namespace: molecular_function
def: "Binding to ganglioside GM2." [GO_REF:0000067, GOC:TermGenie, PMID:1454804]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0035594 ! ganglioside binding

[Term]
id: GO:1905575
name: ganglioside GM3 binding
namespace: molecular_function
def: "Binding to ganglioside GM3." [GO_REF:0000067, GOC:TermGenie, PMID:1454804]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0035594 ! ganglioside binding

[Term]
id: GO:1905576
name: ganglioside GT1b binding
namespace: molecular_function
def: "Binding to ganglioside GT1b." [GO_REF:0000067, GOC:TermGenie, PMID:1454804]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0035594 ! ganglioside binding

[Term]
id: GO:1905577
name: ganglioside GP1c binding
namespace: molecular_function
def: "Binding to ganglioside GP1c." [GO_REF:0000067, GOC:TermGenie, PMID:1454804]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0035594 ! ganglioside binding

[Term]
id: GO:1905578
name: regulation of ERBB3 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365]
synonym: "regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1901184 ! regulation of ERBB signaling pathway
relationship: regulates GO:0038129 ! ERBB3 signaling pathway

[Term]
id: GO:1905579
name: negative regulation of ERBB3 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365]
synonym: "down regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of ERBB3 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of ERBB3 signalling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of HER3 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor tyrosine-protein kinase erbB-3 signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1901185 ! negative regulation of ERBB signaling pathway
is_a: GO:1905578 ! regulation of ERBB3 signaling pathway
relationship: negatively_regulates GO:0038129 ! ERBB3 signaling pathway

[Term]
id: GO:1905580
name: positive regulation of ERBB3 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365]
synonym: "activation of ERBB3 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of ERBB3 signalling pathway" NARROW [GOC:TermGenie]
synonym: "activation of HER3 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of receptor tyrosine-protein kinase erbB-3 signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of HER3 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1901186 ! positive regulation of ERBB signaling pathway
is_a: GO:1905578 ! regulation of ERBB3 signaling pathway
relationship: positively_regulates GO:0038129 ! ERBB3 signaling pathway

[Term]
id: GO:1905581
name: positive regulation of low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
synonym: "activation of LDL clearance" NARROW [GOC:TermGenie]
synonym: "activation of low-density lipoprotein particle clearance" NARROW [GOC:TermGenie]
synonym: "positive regulation of LDL clearance" EXACT [GOC:TermGenie]
synonym: "up regulation of LDL clearance" EXACT [GOC:TermGenie]
synonym: "up regulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie]
synonym: "up-regulation of LDL clearance" EXACT [GOC:TermGenie]
synonym: "up-regulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie]
synonym: "upregulation of LDL clearance" EXACT [GOC:TermGenie]
synonym: "upregulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie]
is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance
is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance
relationship: positively_regulates GO:0034383 ! low-density lipoprotein particle clearance

[Term]
id: GO:1905582
name: response to mannose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16699509]
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:1905583
name: cellular response to mannose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16699509]
is_a: GO:0071331 ! cellular response to hexose stimulus
is_a: GO:1905582 ! response to mannose

[Term]
id: GO:1905584
name: outer hair cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an outer hair cell." [GO_REF:0000085, GOC:TermGenie, PMID:12062759, PMID:24472721]
synonym: "cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "outer hair cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0051402 ! neuron apoptotic process

[Term]
id: GO:1905585
name: regulation of outer hair cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721]
synonym: "regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043523 ! regulation of neuron apoptotic process
relationship: regulates GO:1905584 ! outer hair cell apoptotic process

[Term]
id: GO:1905586
name: negative regulation of outer hair cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721]
synonym: "down regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of outer hair cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:1905585 ! regulation of outer hair cell apoptotic process
relationship: negatively_regulates GO:1905584 ! outer hair cell apoptotic process

[Term]
id: GO:1905587
name: positive regulation of outer hair cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721]
synonym: "activation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of outer hair cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:1905585 ! regulation of outer hair cell apoptotic process
relationship: positively_regulates GO:1905584 ! outer hair cell apoptotic process

[Term]
id: GO:1905588
name: plant-type cell wall modification involved in stomatal movement
namespace: biological_process
def: "Any plant-type cell wall modification that is involved in stomatal movement." [GO_REF:0000060, GOC:TermGenie, PMID:27720618]
synonym: "cellulose and pectin-containing cell wall modification involved in stomatal movement" EXACT [GOC:TermGenie]
is_a: GO:0009827 ! plant-type cell wall modification
relationship: part_of GO:0010118 ! stomatal movement

[Term]
id: GO:1905589
name: positive regulation of L-arginine import across plasma membrane
namespace: biological_process
alt_id: GO:1901042
alt_id: GO:1902828
def: "Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525]
synonym: "activation of L-arginine import" NARROW [GOC:TermGenie]
synonym: "activation of L-arginine import across plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of L-arginine import into cell" NARROW [GOC:TermGenie]
synonym: "activation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-arginine import" BROAD []
synonym: "positive regulation of L-arginine import into cell" EXACT []
synonym: "positive regulation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of L-arginine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-arginine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of L-arginine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of L-arginine uptake" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane
relationship: positively_regulates GO:0097638 ! L-arginine import across plasma membrane

[Term]
id: GO:1905590
name: fibronectin fibril organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril." [GOC:dph, GOC:TermGenie, PMID:20690820]
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:1905591
name: regulation of optical nerve axon regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509]
is_a: GO:0048679 ! regulation of axon regeneration
relationship: regulates GO:0101027 ! optical nerve axon regeneration

[Term]
id: GO:1905592
name: negative regulation of optical nerve axon regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509]
synonym: "down regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of optical nerve axon regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of optical nerve axon regeneration" NARROW [GOC:TermGenie]
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:1905591 ! regulation of optical nerve axon regeneration
relationship: negatively_regulates GO:0101027 ! optical nerve axon regeneration

[Term]
id: GO:1905593
name: positive regulation of optical nerve axon regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509]
synonym: "activation of optical nerve axon regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of optical nerve axon regeneration" EXACT [GOC:TermGenie]
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:1905591 ! regulation of optical nerve axon regeneration
relationship: positively_regulates GO:0101027 ! optical nerve axon regeneration

[Term]
id: GO:1905594
name: resveratrol binding
namespace: molecular_function
def: "Binding to resveratrol." [GO_REF:0000067, GOC:TermGenie, PMID:18254726]
comment: (5-(aziridin-1-yl)-2,4-dinitrobenzamide
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:1905595
name: regulation of low-density lipoprotein particle receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_do_not_annotate
synonym: "regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900120 ! regulation of receptor binding

[Term]
id: GO:1905596
name: negative regulation of low-density lipoprotein particle receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_do_not_annotate
synonym: "down regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of LDL receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding

[Term]
id: GO:1905597
name: positive regulation of low-density lipoprotein particle receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_do_not_annotate
synonym: "activation of LDL receptor binding" NARROW [GOC:TermGenie]
synonym: "activation of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie]
synonym: "activation of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding

[Term]
id: GO:1905598
name: negative regulation of low-density lipoprotein receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "down regulation of LDLR activity" EXACT [GOC:TermGenie]
synonym: "down regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "down-regulation of LDLR activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "downregulation of LDLR activity" EXACT [GOC:TermGenie]
synonym: "downregulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of LDL receptor" NARROW [GOC:TermGenie]
synonym: "inhibition of LDLR activity" NARROW [GOC:TermGenie]
synonym: "inhibition of low-density lipoprotein receptor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "negative regulation of LDLR activity" EXACT [GOC:TermGenie]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis

[Term]
id: GO:1905599
name: positive regulation of low-density lipoprotein receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_obsoletion_candidate
synonym: "activation of LDL receptor" NARROW [GOC:TermGenie]
synonym: "activation of LDLR activity" NARROW [GOC:TermGenie]
synonym: "activation of low-density lipoprotein receptor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "positive regulation of LDLR activity" EXACT [GOC:TermGenie]
synonym: "up regulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "up regulation of LDLR activity" EXACT [GOC:TermGenie]
synonym: "up regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "up-regulation of LDLR activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of LDL receptor" EXACT [GOC:TermGenie]
synonym: "upregulation of LDLR activity" EXACT [GOC:TermGenie]
synonym: "upregulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0044093 ! positive regulation of molecular function

[Term]
id: GO:1905600
name: regulation of receptor-mediated endocytosis involved in cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
synonym: "regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
relationship: regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport

[Term]
id: GO:1905601
name: negative regulation of receptor-mediated endocytosis involved in cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
synonym: "down regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "down regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis involved in cholesterol transport" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "negative regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "negative regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
is_a: GO:0032384 ! negative regulation of intracellular cholesterol transport
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
is_a: GO:1905600 ! regulation of receptor-mediated endocytosis involved in cholesterol transport
relationship: negatively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport

[Term]
id: GO:1905602
name: positive regulation of receptor-mediated endocytosis involved in cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
synonym: "activation of receptor-mediated endocytosis involved in cholesterol transport" NARROW [GOC:TermGenie]
synonym: "activation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "activation of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie]
synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "positive regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "positive regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie]
synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie]
is_a: GO:0032385 ! positive regulation of intracellular cholesterol transport
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
is_a: GO:1905600 ! regulation of receptor-mediated endocytosis involved in cholesterol transport
relationship: positively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport

[Term]
id: GO:1905603
name: regulation of blood-brain barrier permeability
namespace: biological_process
def: "Any process that modulates blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain." [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]
synonym: "regulation of BBB permeability" EXACT []
synonym: "regulation of blood/brain barrier permeability" EXACT []
is_a: GO:0043114 ! regulation of vascular permeability
relationship: part_of GO:0035633 ! maintenance of blood-brain barrier

[Term]
id: GO:1905604
name: negative regulation of blood-brain barrier permeability
namespace: biological_process
def: "Any process that decreases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain." [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]
synonym: "down-regulation of BBB permeability" EXACT []
synonym: "down-regulation of blood-brain barrier permeability" EXACT []
synonym: "down-regulation of blood/brain barrier permeability" EXACT []
synonym: "downregulation of BBB permeability" EXACT []
synonym: "downregulation of blood-brain barrier permeability" EXACT []
synonym: "downregulation of blood/brain barrier permeability" EXACT []
synonym: "inhibition of maintenance of permeability of BBB" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of permeability of blood-brain barrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of BBB permeability" EXACT []
synonym: "negative regulation of blood/brain barrier permeability" EXACT []
is_a: GO:0043116 ! negative regulation of vascular permeability
is_a: GO:1905603 ! regulation of blood-brain barrier permeability

[Term]
id: GO:1905605
name: positive regulation of blood-brain barrier permeability
namespace: biological_process
def: "Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain." [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]
synonym: "activation of maintenance of permeability of BBB" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of permeability of blood-brain barrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of BBB permeability" EXACT []
synonym: "positive regulation of blood/brain barrier permeability" EXACT []
synonym: "up-regulation of BBB permeability" EXACT []
synonym: "up-regulation of blood-brain barrier permeability" EXACT []
synonym: "up-regulation of blood/brain barrier permeability" EXACT []
synonym: "upregulation of BBB permeability" EXACT []
synonym: "upregulation of blood-brain barrier permeability" EXACT []
synonym: "upregulation of blood/brain barrier permeability" EXACT []
is_a: GO:0043117 ! positive regulation of vascular permeability
is_a: GO:1905603 ! regulation of blood-brain barrier permeability

[Term]
id: GO:1905606
name: regulation of presynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
subset: goslim_synapse
synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099174 ! regulation of presynapse organization
relationship: regulates GO:0099054 ! presynapse assembly

[Term]
id: GO:1905607
name: negative regulation of presynapse assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1905606 ! regulation of presynapse assembly
relationship: negatively_regulates GO:0099054 ! presynapse assembly

[Term]
id: GO:1905608
name: positive regulation of presynapse assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie]
synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905606 ! regulation of presynapse assembly
relationship: positively_regulates GO:0099054 ! presynapse assembly

[Term]
id: GO:1905609
name: positive regulation of smooth muscle cell-matrix adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GO_REF:0000058, GOC:TermGenie, PMID:14970114]
synonym: "activation of smooth muscle cell-matrix adhesion" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie]
is_a: GO:0001954 ! positive regulation of cell-matrix adhesion
is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion
relationship: positively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion

[Term]
id: GO:1905610
name: regulation of mRNA cap binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
subset: gocheck_do_not_annotate
is_a: GO:1902415 ! regulation of mRNA binding

[Term]
id: GO:1905611
name: negative regulation of mRNA cap binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
subset: gocheck_do_not_annotate
synonym: "down regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA cap binding" NARROW [GOC:TermGenie]
is_a: GO:1904572 ! negative regulation of mRNA binding
is_a: GO:1905610 ! regulation of mRNA cap binding

[Term]
id: GO:1905612
name: positive regulation of mRNA cap binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
subset: gocheck_do_not_annotate
synonym: "activation of mRNA cap binding" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA cap binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1905610 ! regulation of mRNA cap binding

[Term]
id: GO:1905613
name: regulation of developmental vegetative growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552]
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0080186 ! developmental vegetative growth

[Term]
id: GO:1905614
name: negative regulation of developmental vegetative growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552]
synonym: "down regulation of developmental vegetative growth" EXACT [GOC:TermGenie]
synonym: "down-regulation of developmental vegetative growth" EXACT [GOC:TermGenie]
synonym: "downregulation of developmental vegetative growth" EXACT [GOC:TermGenie]
synonym: "inhibition of developmental vegetative growth" NARROW [GOC:TermGenie]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1905613 ! regulation of developmental vegetative growth
relationship: negatively_regulates GO:0080186 ! developmental vegetative growth

[Term]
id: GO:1905615
name: positive regulation of developmental vegetative growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552]
synonym: "activation of developmental vegetative growth" NARROW [GOC:TermGenie]
synonym: "up regulation of developmental vegetative growth" EXACT [GOC:TermGenie]
synonym: "up-regulation of developmental vegetative growth" EXACT [GOC:TermGenie]
synonym: "upregulation of developmental vegetative growth" EXACT [GOC:TermGenie]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1905613 ! regulation of developmental vegetative growth
relationship: positively_regulates GO:0080186 ! developmental vegetative growth

[Term]
id: GO:1905616
name: obsolete regulation of miRNA-mediated gene silencing by inhibition of translation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
comment: This term was obsoleted because it represents regulation of a regulatory process and has been used incorrectly
synonym: "regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "regulation of miRNA mediated inhibition of translation" EXACT []
synonym: "regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0035278
consider: GO:0060964

[Term]
id: GO:1905617
name: obsolete negative regulation of miRNA-mediated gene silencing by inhibition of translation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
comment: This term was obsoleted because it represents regulation of a regulatory process and has been used incorrectly
synonym: "down regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "down regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "down regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie]
synonym: "down regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "down regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "down-regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie]
synonym: "down-regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "down-regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "downregulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie]
synonym: "downregulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "downregulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "inhibition of down regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "inhibition of down-regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "inhibition of downregulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "inhibition of gene silencing by miRNA, negative regulation of translation" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "inhibition of miRNA mediated inhibition of translation" NARROW [GOC:TermGenie]
synonym: "inhibition of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "inhibition of negative regulation of translation involved in gene silencing by microRNA" NARROW [GOC:TermGenie]
synonym: "negative regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "negative regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "negative regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "negative regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "negative regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "negative regulation of miRNA mediated inhibition of translation" EXACT []
synonym: "negative regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "negative regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0035278
consider: GO:0060965

[Term]
id: GO:1905618
name: obsolete positive regulation of miRNA-mediated gene silencing by inhibition of translation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
comment: This term was obsoleted because it represents regulation of a regulatory process and has been used incorrectly
synonym: "activation of down regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "activation of down-regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "activation of downregulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "activation of gene silencing by miRNA, negative regulation of translation" NARROW [GOC:TermGenie]
synonym: "activation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "activation of miRNA mediated inhibition of translation" NARROW [GOC:TermGenie]
synonym: "activation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "activation of negative regulation of translation involved in gene silencing by microRNA" NARROW [GOC:TermGenie]
synonym: "positive regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "positive regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "positive regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "positive regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "positive regulation of miRNA mediated inhibition of translation" EXACT []
synonym: "positive regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "positive regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "up regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie]
synonym: "up regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "up regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "up-regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie]
synonym: "up-regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "up-regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "upregulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie]
synonym: "upregulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie]
synonym: "upregulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0035278
consider: GO:2000637

[Term]
id: GO:1905619
name: regulation of alpha-(1->3)-fucosyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955]
subset: gocheck_obsoletion_candidate
synonym: "regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1905620
name: obsolete negative regulation of alpha-(1->3)-fucosyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of alpha(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of alpha-(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of alpha-(1->3)-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of alpha-1,3-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905621
name: obsolete positive regulation of alpha-(1->3)-fucosyltransferase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of alpha(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of alpha-(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of alpha-(1->3)-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of alpha-1,3-fucosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905622
name: negative regulation of leaf development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leaf development." [GO_REF:0000058, GOC:TermGenie, PMID:11606552]
synonym: "down regulation of leaf development" EXACT [GOC:TermGenie]
synonym: "down-regulation of leaf development" EXACT [GOC:TermGenie]
synonym: "downregulation of leaf development" EXACT [GOC:TermGenie]
synonym: "inhibition of leaf development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000024 ! regulation of leaf development
relationship: negatively_regulates GO:0048366 ! leaf development

[Term]
id: GO:1905623
name: positive regulation of leaf development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leaf development." [GO_REF:0000058, GOC:TermGenie, PMID:11606552]
synonym: "activation of leaf development" NARROW [GOC:TermGenie]
synonym: "up regulation of leaf development" EXACT [GOC:TermGenie]
synonym: "up-regulation of leaf development" EXACT [GOC:TermGenie]
synonym: "upregulation of leaf development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000024 ! regulation of leaf development
relationship: positively_regulates GO:0048366 ! leaf development

[Term]
id: GO:1905624
name: regulation of L-methionine import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:1905544 ! L-methionine import across plasma membrane

[Term]
id: GO:1905625
name: negative regulation of L-methionine import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane
relationship: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane

[Term]
id: GO:1905626
name: positive regulation of L-methionine import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane
relationship: positively_regulates GO:1905544 ! L-methionine import across plasma membrane

[Term]
id: GO:1905627
name: regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0042427 ! serotonin biosynthetic process

[Term]
id: GO:1905628
name: negative regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1905627 ! regulation of serotonin biosynthetic process
relationship: negatively_regulates GO:0042427 ! serotonin biosynthetic process

[Term]
id: GO:1905629
name: positive regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie]
synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of serotonin formation" NARROW [GOC:TermGenie]
synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1905627 ! regulation of serotonin biosynthetic process
relationship: positively_regulates GO:0042427 ! serotonin biosynthetic process

[Term]
id: GO:1905630
name: response to glyceraldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11377826]
is_a: GO:0034284 ! response to monosaccharide

[Term]
id: GO:1905631
name: cellular response to glyceraldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11377826]
is_a: GO:0071326 ! cellular response to monosaccharide stimulus
is_a: GO:1905630 ! response to glyceraldehyde

[Term]
id: GO:1905632
name: protein localization to euchromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714]
synonym: "protein localisation in euchromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to euchromatin" EXACT [GOC:TermGenie]
synonym: "protein localization in euchromatin" EXACT [GOC:TermGenie]
is_a: GO:0071168 ! protein localization to chromatin

[Term]
id: GO:1905633
name: establishment of protein localization to euchromatin
namespace: biological_process
def: "The directed movement of a protein to a specific location in an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714]
synonym: "establishment of protein localisation in euchromatin" EXACT [GOC:TermGenie]
synonym: "establishment of protein localisation to euchromatin" EXACT [GOC:TermGenie]
synonym: "establishment of protein localization in euchromatin" EXACT [GOC:TermGenie]
is_a: GO:0071169 ! establishment of protein localization to chromatin
is_a: GO:1905632 ! protein localization to euchromatin

[Term]
id: GO:1905634
name: regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714]
synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0071168 ! protein localization to chromatin

[Term]
id: GO:1905635
name: FACT complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a FACT complex." [GO_REF:0000079, GOC:TermGenie, PMID:20889714]
synonym: "Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "FACT complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905636
name: positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23675531]
subset: gocheck_do_not_annotate
synonym: "activation of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding

[Term]
id: GO:1905637
name: regulation of mitochondrial mRNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0061013 ! regulation of mRNA catabolic process
relationship: regulates GO:0000958 ! mitochondrial mRNA catabolic process

[Term]
id: GO:1905638
name: negative regulation of mitochondrial mRNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350]
synonym: "down regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial mRNA catabolic process" NARROW [GOC:TermGenie]
is_a: GO:0000961 ! negative regulation of mitochondrial RNA catabolic process
is_a: GO:1902373 ! negative regulation of mRNA catabolic process
is_a: GO:1905637 ! regulation of mitochondrial mRNA catabolic process
relationship: negatively_regulates GO:0000958 ! mitochondrial mRNA catabolic process

[Term]
id: GO:1905639
name: positive regulation of mitochondrial mRNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350]
synonym: "activation of mitochondrial mRNA catabolic process" NARROW [GOC:TermGenie]
synonym: "up regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie]
is_a: GO:0000962 ! positive regulation of mitochondrial RNA catabolic process
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:1905637 ! regulation of mitochondrial mRNA catabolic process
relationship: positively_regulates GO:0000958 ! mitochondrial mRNA catabolic process

[Term]
id: GO:1905640
name: response to acetaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:27687866]
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905641
name: cellular response to acetaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:27687866]
is_a: GO:0110096 ! cellular response to aldehyde
is_a: GO:1905640 ! response to acetaldehyde

[Term]
id: GO:1905642
name: obsolete negative regulation of DNA methylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847]
comment: This term was obsoleted because it represents regulation of a molecular function.
synonym: "down regulation of DNA methylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA methylation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA methylation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA methylation" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0004857
consider: GO:0040029

[Term]
id: GO:1905643
name: obsolete positive regulation of DNA methylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847]
comment: This term was obsoleted because it represents regulation of a molecular function.
synonym: "activation of DNA methylation" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA methylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA methylation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA methylation" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0008047
consider: GO:0040029

[Term]
id: GO:1905644
name: regulation of FACT complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714]
synonym: "regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of FACT complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1905635 ! FACT complex assembly

[Term]
id: GO:1905645
name: negative regulation of FACT complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714]
synonym: "down regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of FACT complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of FACT complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of FACT complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of FACT complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of FACT complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of FACT complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of Facilitates chromatin transcription complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Facilitates chromatin transcription complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of FACT complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of FACT complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of FACT complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1905644 ! regulation of FACT complex assembly
relationship: negatively_regulates GO:1905635 ! FACT complex assembly

[Term]
id: GO:1905646
name: positive regulation of FACT complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714]
synonym: "activation of Facilitates chromatin transcription complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Facilitates chromatin transcription complex formation" NARROW [GOC:TermGenie]
synonym: "activation of FACT complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of FACT complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of FACT complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of FACT complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of FACT complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of FACT complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of FACT complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of FACT complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of FACT complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1905644 ! regulation of FACT complex assembly
relationship: positively_regulates GO:1905635 ! FACT complex assembly

[Term]
id: GO:1905647
name: proline import across plasma membrane
namespace: biological_process
alt_id: GO:1902825
def: "The directed movement of proline from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:TermGenie, PMID:24344203]
synonym: "proline import into cell" EXACT []
is_a: GO:0035524 ! proline transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane

[Term]
id: GO:1905648
name: regulation of shell calcification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763]
is_a: GO:0070167 ! regulation of biomineral tissue development
relationship: regulates GO:0031215 ! shell calcification

[Term]
id: GO:1905649
name: negative regulation of shell calcification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763]
synonym: "down regulation of shell calcification" EXACT [GOC:TermGenie]
synonym: "down-regulation of shell calcification" EXACT [GOC:TermGenie]
synonym: "downregulation of shell calcification" EXACT [GOC:TermGenie]
synonym: "inhibition of shell calcification" NARROW [GOC:TermGenie]
is_a: GO:0070168 ! negative regulation of biomineral tissue development
is_a: GO:1905648 ! regulation of shell calcification
relationship: negatively_regulates GO:0031215 ! shell calcification

[Term]
id: GO:1905650
name: positive regulation of shell calcification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763]
synonym: "activation of shell calcification" NARROW [GOC:TermGenie]
synonym: "up regulation of shell calcification" EXACT [GOC:TermGenie]
synonym: "up-regulation of shell calcification" EXACT [GOC:TermGenie]
synonym: "upregulation of shell calcification" EXACT [GOC:TermGenie]
is_a: GO:0070169 ! positive regulation of biomineral tissue development
is_a: GO:1905648 ! regulation of shell calcification
relationship: positively_regulates GO:0031215 ! shell calcification

[Term]
id: GO:1905651
name: regulation of artery morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0048844 ! artery morphogenesis

[Term]
id: GO:1905652
name: negative regulation of artery morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie]
is_a: GO:1905651 ! regulation of artery morphogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
relationship: negatively_regulates GO:0048844 ! artery morphogenesis

[Term]
id: GO:1905653
name: positive regulation of artery morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie]
synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905651 ! regulation of artery morphogenesis
relationship: positively_regulates GO:0048844 ! artery morphogenesis

[Term]
id: GO:1905654
name: regulation of artery smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
relationship: regulates GO:0014824 ! artery smooth muscle contraction

[Term]
id: GO:1905655
name: negative regulation of artery smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "down regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of artery smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction
is_a: GO:1905654 ! regulation of artery smooth muscle contraction
relationship: negatively_regulates GO:0014824 ! artery smooth muscle contraction

[Term]
id: GO:1905656
name: positive regulation of artery smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "activation of artery smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction
is_a: GO:1905654 ! regulation of artery smooth muscle contraction
relationship: positively_regulates GO:0014824 ! artery smooth muscle contraction

[Term]
id: GO:1905660
name: mitotic checkpoint complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitotic checkpoint complex." [GO_REF:0000079, GOC:TermGenie, PMID:26882497]
synonym: "MCC assembly" EXACT [GOC:TermGenie]
synonym: "MCC formation" EXACT [GOC:TermGenie]
synonym: "mitotic checkpoint complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905661
name: obsolete regulation of telomerase RNA reverse transcriptase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954]
comment: This term was obsoleted because it represents the same activity as regulation of telomerase activity ; GO:0051972.
synonym: "regulation of telomerase, catalyst" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905662
name: obsolete negative regulation of telomerase RNA reverse transcriptase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954]
comment: This term was obsoleted because it represents the same activity as negative regulation of telomerase activity ; GO:0051974.
synonym: "down regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of telomerase, catalyst" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomerase, catalyst" EXACT [GOC:TermGenie]
synonym: "downregulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of telomerase, catalyst" EXACT [GOC:TermGenie]
synonym: "inhibition of telomerase RNA reverse transcriptase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of telomerase, catalyst" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomerase, catalyst" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905663
name: obsolete positive regulation of telomerase RNA reverse transcriptase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954]
comment: This term was obsoleted because it represents the same activity as positive regulation of telomerase activity ; GO:0051973
synonym: "activation of telomerase RNA reverse transcriptase activity" NARROW [GOC:TermGenie]
synonym: "activation of telomerase, catalyst" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomerase, catalyst" EXACT [GOC:TermGenie]
synonym: "up regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of telomerase, catalyst" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomerase, catalyst" EXACT [GOC:TermGenie]
synonym: "upregulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of telomerase, catalyst" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905664
name: regulation of calcium ion import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]
comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay).
is_a: GO:0090279 ! regulation of calcium ion import
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
relationship: regulates GO:0098703 ! calcium ion import across plasma membrane

[Term]
id: GO:1905665
name: positive regulation of calcium ion import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]
comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay).
synonym: "activation of calcium ion import across plasma membrane" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:0090280 ! positive regulation of calcium ion import
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane
relationship: positively_regulates GO:0098703 ! calcium ion import across plasma membrane

[Term]
id: GO:1905666
name: regulation of protein localization to endosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145]
synonym: "regulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in endosome" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0036010 ! protein localization to endosome

[Term]
id: GO:1905667
name: negative regulation of protein localization to endosome
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145]
synonym: "down regulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in endosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to endosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in endosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to endosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in endosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to endosome" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in endosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in endosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to endosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in endosome" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905666 ! regulation of protein localization to endosome
relationship: negatively_regulates GO:0036010 ! protein localization to endosome

[Term]
id: GO:1905668
name: positive regulation of protein localization to endosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145]
synonym: "activation of protein localisation in endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to endosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to endosome" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905666 ! regulation of protein localization to endosome
relationship: positively_regulates GO:0036010 ! protein localization to endosome

[Term]
id: GO:1905669
name: TORC1 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218]
synonym: "dTOR/dRaptor complex assembly" NARROW [GOC:TermGenie]
synonym: "dTOR/dRaptor complex formation" NARROW [GOC:TermGenie]
synonym: "dTORC1 assembly" NARROW [GOC:TermGenie]
synonym: "dTORC1 formation" NARROW [GOC:TermGenie]
synonym: "mTORC1 assembly" NARROW [GOC:TermGenie]
synonym: "mTORC1 formation" NARROW [GOC:TermGenie]
synonym: "nutrient sensitive complex assembly" EXACT [GOC:TermGenie]
synonym: "nutrient sensitive complex formation" EXACT [GOC:TermGenie]
synonym: "rapamycin and nutrient-sensitive TOR complex assembly" EXACT [GOC:TermGenie]
synonym: "rapamycin and nutrient-sensitive TOR complex formation" EXACT [GOC:TermGenie]
synonym: "TOR complex 1 assembly" EXACT [GOC:TermGenie]
synonym: "TOR complex 1 formation" EXACT [GOC:TermGenie]
synonym: "TORC 1 complex assembly" EXACT [GOC:TermGenie]
synonym: "TORC 1 complex formation" EXACT [GOC:TermGenie]
synonym: "TORC1 assembly" EXACT [GOC:TermGenie]
synonym: "TORC1 complex formation" EXACT [GOC:TermGenie]
synonym: "TORC1 formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1905670
name: TORC2 complex disassembly
namespace: biological_process
def: "The disaggregation of a TORC2 complex into its constituent components." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218]
synonym: "mTORC2 disassembly" NARROW [GOC:TermGenie]
synonym: "rapamycin and nutrient-insensitive TOR complex disassembly" EXACT [GOC:TermGenie]
synonym: "TOR complex 2 disassembly" EXACT [GOC:TermGenie]
synonym: "TORC 2 complex disassembly" EXACT [GOC:TermGenie]
synonym: "TORC2 disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:1905671
name: regulation of lysosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470]
synonym: "regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0044088 ! regulation of vacuole organization
relationship: regulates GO:0007040 ! lysosome organization

[Term]
id: GO:1905672
name: negative regulation of lysosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470]
synonym: "down regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of lysosome organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosome organization" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1905671 ! regulation of lysosome organization
relationship: negatively_regulates GO:0007040 ! lysosome organization

[Term]
id: GO:1905673
name: positive regulation of lysosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470]
synonym: "activation of lysosome organisation" NARROW [GOC:TermGenie]
synonym: "activation of lysosome organization" NARROW [GOC:TermGenie]
synonym: "activation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0044090 ! positive regulation of vacuole organization
is_a: GO:1905671 ! regulation of lysosome organization
relationship: positively_regulates GO:0007040 ! lysosome organization

[Term]
id: GO:1905674
name: regulation of adaptive immune memory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526]
is_a: GO:0002819 ! regulation of adaptive immune response
relationship: regulates GO:0090716 ! adaptive immune memory response

[Term]
id: GO:1905675
name: negative regulation of adaptive immune memory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526]
synonym: "down regulation of adaptive immune memory response" EXACT [GOC:TermGenie]
synonym: "down-regulation of adaptive immune memory response" EXACT [GOC:TermGenie]
synonym: "downregulation of adaptive immune memory response" EXACT [GOC:TermGenie]
synonym: "inhibition of adaptive immune memory response" NARROW [GOC:TermGenie]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:1905674 ! regulation of adaptive immune memory response
relationship: negatively_regulates GO:0090716 ! adaptive immune memory response

[Term]
id: GO:1905676
name: positive regulation of adaptive immune memory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526]
synonym: "activation of adaptive immune memory response" NARROW [GOC:TermGenie]
synonym: "up regulation of adaptive immune memory response" EXACT [GOC:TermGenie]
synonym: "up-regulation of adaptive immune memory response" EXACT [GOC:TermGenie]
synonym: "upregulation of adaptive immune memory response" EXACT [GOC:TermGenie]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:1905674 ! regulation of adaptive immune memory response
relationship: positively_regulates GO:0090716 ! adaptive immune memory response

[Term]
id: GO:1905677
name: regulation of adaptive immune effector response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833]
is_a: GO:0002819 ! regulation of adaptive immune response
relationship: regulates GO:0090718 ! adaptive immune effector response

[Term]
id: GO:1905678
name: negative regulation of adaptive immune effector response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833]
synonym: "down regulation of adaptive immune effector response" EXACT [GOC:TermGenie]
synonym: "down-regulation of adaptive immune effector response" EXACT [GOC:TermGenie]
synonym: "downregulation of adaptive immune effector response" EXACT [GOC:TermGenie]
synonym: "inhibition of adaptive immune effector response" NARROW [GOC:TermGenie]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:1905677 ! regulation of adaptive immune effector response
relationship: negatively_regulates GO:0090718 ! adaptive immune effector response

[Term]
id: GO:1905679
name: positive regulation of adaptive immune effector response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833]
synonym: "activation of adaptive immune effector response" NARROW [GOC:TermGenie]
synonym: "up regulation of adaptive immune effector response" EXACT [GOC:TermGenie]
synonym: "up-regulation of adaptive immune effector response" EXACT [GOC:TermGenie]
synonym: "upregulation of adaptive immune effector response" EXACT [GOC:TermGenie]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:1905677 ! regulation of adaptive immune effector response
relationship: positively_regulates GO:0090718 ! adaptive immune effector response

[Term]
id: GO:1905680
name: regulation of innate immunity memory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie]
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0090714 ! innate immunity memory response

[Term]
id: GO:1905681
name: negative regulation of innate immunity memory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie]
synonym: "down regulation of innate immunity memory response" EXACT [GOC:TermGenie]
synonym: "down-regulation of innate immunity memory response" EXACT [GOC:TermGenie]
synonym: "downregulation of innate immunity memory response" EXACT [GOC:TermGenie]
synonym: "inhibition of innate immunity memory response" NARROW [GOC:TermGenie]
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:1905680 ! regulation of innate immunity memory response
relationship: negatively_regulates GO:0090714 ! innate immunity memory response

[Term]
id: GO:1905682
name: positive regulation of innate immunity memory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie]
synonym: "activation of innate immunity memory response" NARROW [GOC:TermGenie]
synonym: "up regulation of innate immunity memory response" EXACT [GOC:TermGenie]
synonym: "up-regulation of innate immunity memory response" EXACT [GOC:TermGenie]
synonym: "upregulation of innate immunity memory response" EXACT [GOC:TermGenie]
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:1905680 ! regulation of innate immunity memory response
relationship: positively_regulates GO:0090714 ! innate immunity memory response

[Term]
id: GO:1905683
name: obsolete peroxisome disassembly
namespace: biological_process
def: "OBSOLETE. The disaggregation of a peroxisome into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]
comment: The reason for obsoletion is that this term was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0030242

[Term]
id: GO:1905684
name: regulation of plasma membrane repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]
is_a: GO:1903729 ! regulation of plasma membrane organization
relationship: regulates GO:0001778 ! plasma membrane repair

[Term]
id: GO:1905685
name: negative regulation of plasma membrane repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]
synonym: "down regulation of plasma membrane repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma membrane repair" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma membrane repair" EXACT [GOC:TermGenie]
synonym: "inhibition of plasma membrane repair" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1905684 ! regulation of plasma membrane repair
relationship: negatively_regulates GO:0001778 ! plasma membrane repair

[Term]
id: GO:1905686
name: positive regulation of plasma membrane repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]
synonym: "activation of plasma membrane repair" NARROW [GOC:TermGenie]
synonym: "up regulation of plasma membrane repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma membrane repair" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma membrane repair" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905684 ! regulation of plasma membrane repair
relationship: positively_regulates GO:0001778 ! plasma membrane repair

[Term]
id: GO:1905687
name: regulation of diacylglycerol kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0043550 ! regulation of lipid kinase activity

[Term]
id: GO:1905688
name: obsolete negative regulation of diacylglycerol kinase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 1,2-diacylglycerol kinase (phosphorylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of 1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of arachidonoyl-specific diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DG kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DGK activity" NARROW [GOC:TermGenie]
synonym: "inhibition of diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of diglyceride kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sn-1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905689
name: positive regulation of diacylglycerol kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060]
subset: gocheck_obsoletion_candidate
synonym: "activation of 1,2-diacylglycerol kinase (phosphorylating)" NARROW [GOC:TermGenie]
synonym: "activation of 1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of arachidonoyl-specific diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of DG kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of DGK activity" NARROW [GOC:TermGenie]
synonym: "activation of diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of diglyceride kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of sn-1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of DG kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DGK activity" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of diglyceride kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0090218 ! positive regulation of lipid kinase activity
is_a: GO:1905687 ! regulation of diacylglycerol kinase activity

[Term]
id: GO:1905690
name: nucleus disassembly
namespace: biological_process
def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]
synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie]
is_a: GO:0006997 ! nucleus organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:1905691
name: lipid droplet disassembly
namespace: biological_process
def: "The disaggregation of a lipid particle into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]
synonym: "adiposome disassembly" EXACT [GOC:TermGenie]
synonym: "lipid body disassembly" EXACT [GOC:TermGenie]
synonym: "lipid droplet reserve breakdown" EXACT [PMID:30003614]
synonym: "lipid particle disassembly" EXACT [GOC:TermGenie]
is_a: GO:0034389 ! lipid droplet organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:1905692
name: endoplasmic reticulum disassembly
namespace: biological_process
def: "The disaggregation of an endoplasmic reticulum into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]
synonym: "ER disassembly" EXACT [GOC:TermGenie]
is_a: GO:0007029 ! endoplasmic reticulum organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:1905693
name: regulation of phosphatidic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959]
synonym: "regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0006654 ! phosphatidic acid biosynthetic process

[Term]
id: GO:1905694
name: negative regulation of phosphatidic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959]
synonym: "down regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidic acid anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidic acid biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidic acid formation" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidic acid synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:1905693 ! regulation of phosphatidic acid biosynthetic process
relationship: negatively_regulates GO:0006654 ! phosphatidic acid biosynthetic process

[Term]
id: GO:1905695
name: positive regulation of phosphatidic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959]
synonym: "activation of phosphatidic acid anabolism" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidic acid biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidic acid formation" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidic acid synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidic acid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:1905693 ! regulation of phosphatidic acid biosynthetic process
relationship: positively_regulates GO:0006654 ! phosphatidic acid biosynthetic process

[Term]
id: GO:1905696
name: obsolete regulation of polysome binding
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
comment: This term is outside the scope of GO.
synonym: "regulation of polyribosome binding" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905697
name: obsolete negative regulation of polysome binding
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
comment: This term is outside the scope of GO.
synonym: "down regulation of polyribosome binding" EXACT [GOC:TermGenie]
synonym: "down regulation of polysome binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyribosome binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of polysome binding" EXACT [GOC:TermGenie]
synonym: "downregulation of polyribosome binding" EXACT [GOC:TermGenie]
synonym: "downregulation of polysome binding" EXACT [GOC:TermGenie]
synonym: "inhibition of polyribosome binding" NARROW [GOC:TermGenie]
synonym: "inhibition of polysome binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of polyribosome binding" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:0043022

[Term]
id: GO:1905698
name: obsolete positive regulation of polysome binding
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]
comment: This term is outside the scope of GO.
synonym: "activation of polyribosome binding" NARROW [GOC:TermGenie]
synonym: "activation of polysome binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of polyribosome binding" EXACT [GOC:TermGenie]
synonym: "up regulation of polyribosome binding" EXACT [GOC:TermGenie]
synonym: "up regulation of polysome binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyribosome binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of polysome binding" EXACT [GOC:TermGenie]
synonym: "upregulation of polyribosome binding" EXACT [GOC:TermGenie]
synonym: "upregulation of polysome binding" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905699
name: regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509]
synonym: "regulation of drug transmembrane export" NARROW []
synonym: "regulation of xenobiotic transmembrane export" NARROW []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:2001023 ! regulation of response to drug
relationship: regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane

[Term]
id: GO:1905700
name: negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509]
synonym: "down regulation of drug transmembrane export" NARROW [GOC:TermGenie]
synonym: "down-regulation of drug transmembrane export" NARROW [GOC:TermGenie]
synonym: "downregulation of drug transmembrane export" NARROW [GOC:TermGenie]
synonym: "inhibition of drug transmembrane export" NARROW [GOC:TermGenie]
synonym: "negative regulation of drug transmembrane export" NARROW []
synonym: "negative regulation of xenobiotic transmembrane export" NARROW []
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1905699 ! regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
is_a: GO:2001024 ! negative regulation of response to drug
relationship: negatively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane

[Term]
id: GO:1905701
name: positive regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509]
synonym: "activation of drug transmembrane export" NARROW [GOC:TermGenie]
synonym: "positive regulation of drug transmembrane export" NARROW []
synonym: "positive regulation of xenobiotic transmembrane export" NARROW []
synonym: "up regulation of drug transmembrane export" NARROW [GOC:TermGenie]
synonym: "up-regulation of drug transmembrane export" NARROW [GOC:TermGenie]
synonym: "upregulation of drug transmembrane export" NARROW [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1905699 ! regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
relationship: positively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane

[Term]
id: GO:1905702
name: regulation of inhibitory synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "regulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
relationship: regulates GO:1904862 ! inhibitory synapse assembly

[Term]
id: GO:1905703
name: negative regulation of inhibitory synapse assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibitory synapse assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
synonym: "inhibition of inhibitory synapse assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibitory synapse formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1905702 ! regulation of inhibitory synapse assembly
relationship: negatively_regulates GO:1904862 ! inhibitory synapse assembly

[Term]
id: GO:1905704
name: positive regulation of inhibitory synapse assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "activation of inhibitory synapse assembly" NARROW [GOC:TermGenie]
synonym: "activation of inhibitory synapse formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitory synapse assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051965 ! positive regulation of synapse assembly
is_a: GO:1905702 ! regulation of inhibitory synapse assembly
relationship: positively_regulates GO:1904862 ! inhibitory synapse assembly

[Term]
id: GO:1905705
name: obsolete cellular response to paclitaxel
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18472094]
comment: This term was obsoleted because it represents a response to xenobiotic stimulus, and GO terms are not created for every xenobiotic.
is_obsolete: true
replaced_by: GO:0009410

[Term]
id: GO:1905706
name: regulation of mitochondrial ATP synthesis coupled proton transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286]
is_a: GO:2001169 ! regulation of ATP biosynthetic process
relationship: regulates GO:0042776 ! proton motive force-driven mitochondrial ATP synthesis

[Term]
id: GO:1905707
name: negative regulation of mitochondrial ATP synthesis coupled proton transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286]
is_a: GO:1905706 ! regulation of mitochondrial ATP synthesis coupled proton transport
is_a: GO:2001170 ! negative regulation of ATP biosynthetic process
relationship: negatively_regulates GO:0042776 ! proton motive force-driven mitochondrial ATP synthesis

[Term]
id: GO:1905708
name: regulation of cell morphogenesis involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the location, frequency, rate or extent of cell morphogenesis involved in conjugation with cellular fusion." [GO_REF:0000058, GOC:TermGenie, PMID:23200991]
synonym: "regulation of shmoo orientation" NARROW [GOC:TermGenie]
synonym: "regulation of shmooing" NARROW [GOC:TermGenie]
is_a: GO:0022604 ! regulation of cell morphogenesis
relationship: regulates GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion

[Term]
id: GO:1905709
name: negative regulation of membrane permeability
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894]
is_a: GO:0090559 ! regulation of membrane permeability

[Term]
id: GO:1905710
name: positive regulation of membrane permeability
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894]
is_a: GO:0090559 ! regulation of membrane permeability

[Term]
id: GO:1905711
name: response to phosphatidylethanolamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1657995]
synonym: "response to PE" EXACT []
synonym: "response to phosphatidyl(amino)ethanols" EXACT []
synonym: "response to phosphatidylethanolamines" EXACT []
synonym: "response to PtdEtn" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905712
name: cellular response to phosphatidylethanolamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1657995]
synonym: "cellular response to PE" EXACT []
synonym: "cellular response to phosphatidyl(amino)ethanols" EXACT []
synonym: "cellular response to phosphatidylethanolamines" EXACT []
synonym: "cellular response to PtdEtn" EXACT []
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905711 ! response to phosphatidylethanolamine

[Term]
id: GO:1905713
name: obsolete mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "OBSOLETE. Any mitochondrial calcium uptake that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie]
synonym: "mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905714
name: obsolete mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "OBSOLETE. Any mitochondrial calcium release that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie]
synonym: "mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905715
name: regulation of cornification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679]
is_a: GO:0043067 ! regulation of programmed cell death
relationship: regulates GO:0070268 ! cornification

[Term]
id: GO:1905716
name: negative regulation of cornification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679]
synonym: "down regulation of cornification" EXACT [GOC:TermGenie]
synonym: "down-regulation of cornification" EXACT [GOC:TermGenie]
synonym: "downregulation of cornification" EXACT [GOC:TermGenie]
synonym: "inhibition of cornification" NARROW [GOC:TermGenie]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:1905715 ! regulation of cornification
relationship: negatively_regulates GO:0070268 ! cornification

[Term]
id: GO:1905717
name: positive regulation of cornification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679]
synonym: "activation of cornification" NARROW [GOC:TermGenie]
synonym: "up regulation of cornification" EXACT [GOC:TermGenie]
synonym: "up-regulation of cornification" EXACT [GOC:TermGenie]
synonym: "upregulation of cornification" EXACT [GOC:TermGenie]
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:1905715 ! regulation of cornification
relationship: positively_regulates GO:0070268 ! cornification

[Term]
id: GO:1905718
name: obsolete mitotic spindle astral microtubule end
namespace: cellular_component
def: "OBSOLETE. Any microtubule end that is part of a mitotic spindle astral microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "mitotic spindle astral microtubule tip" EXACT []
is_obsolete: true

[Term]
id: GO:1905719
name: protein localization to perinuclear region of cytoplasm
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm." [GO_REF:0000087, GOC:TermGenie, PMID:15177031]
synonym: "protein localisation in perinuclear region of cytoplasm" EXACT [GOC:TermGenie]
synonym: "protein localisation to perinuclear region of cytoplasm" EXACT [GOC:TermGenie]
synonym: "protein localization in perinuclear region of cytoplasm" EXACT [GOC:TermGenie]
synonym: "protein localization to perinuclear cytoplasm" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1905720
name: cytoplasmic microtubule bundle
namespace: cellular_component
def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291]
synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie]
synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie]
is_a: GO:0097427 ! microtubule bundle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:1905721
name: mitotic spindle astral microtubule end
namespace: cellular_component
def: "Any microtubule end that is part of a mitotic spindle astral microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487]
synonym: "mitotic spindle astral microtubule tip" EXACT []
is_a: GO:1990752 ! microtubule end
relationship: part_of GO:0061673 ! mitotic spindle astral microtubule

[Term]
id: GO:1905722
name: regulation of trypanothione biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025]
synonym: "regulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "regulation of trypanothione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0019342 ! trypanothione biosynthetic process

[Term]
id: GO:1905723
name: negative regulation of trypanothione biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025]
synonym: "down regulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "down regulation of trypanothione synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trypanothione synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "downregulation of trypanothione synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of trypanothione anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of trypanothione biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of trypanothione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of trypanothione formation" NARROW [GOC:TermGenie]
synonym: "inhibition of trypanothione synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of trypanothione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1905722 ! regulation of trypanothione biosynthetic process
relationship: negatively_regulates GO:0019342 ! trypanothione biosynthetic process

[Term]
id: GO:1905724
name: positive regulation of trypanothione biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025]
synonym: "activation of trypanothione anabolism" NARROW [GOC:TermGenie]
synonym: "activation of trypanothione biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of trypanothione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of trypanothione formation" NARROW [GOC:TermGenie]
synonym: "activation of trypanothione synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of trypanothione synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "up regulation of trypanothione synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trypanothione synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of trypanothione anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of trypanothione biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of trypanothione formation" EXACT [GOC:TermGenie]
synonym: "upregulation of trypanothione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1905722 ! regulation of trypanothione biosynthetic process
relationship: positively_regulates GO:0019342 ! trypanothione biosynthetic process

[Term]
id: GO:1905725
name: protein localization to microtubule end
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at a microtubule end." [GO_REF:0000087, GOC:TermGenie, PMID:12034771]
synonym: "protein localisation to microtubule end" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule

[Term]
id: GO:1905735
name: regulation of L-proline import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:0070881 ! regulation of proline transport
is_a: GO:1902834 ! regulation of proline import across plasma membrane
relationship: regulates GO:1904271 ! L-proline import across plasma membrane

[Term]
id: GO:1905736
name: negative regulation of L-proline import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:1902835 ! negative regulation of proline import across plasma membrane
is_a: GO:1905735 ! regulation of L-proline import across plasma membrane
relationship: negatively_regulates GO:1904271 ! L-proline import across plasma membrane

[Term]
id: GO:1905737
name: positive regulation of L-proline import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:1902836 ! positive regulation of proline import across plasma membrane
is_a: GO:1905735 ! regulation of L-proline import across plasma membrane
relationship: positively_regulates GO:1904271 ! L-proline import across plasma membrane

[Term]
id: GO:1905741
name: calcium export from the mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any mitochondrial calcium release that is involved in positive regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474]
synonym: "calcium ion transmembrane export from mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie]
synonym: "mitochondrial calcium release involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099093 ! calcium export from the mitochondrion
relationship: part_of GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration

[Term]
id: GO:1905742
name: Ras guanyl-nucleotide exchange factor complex
namespace: cellular_component
def: "A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity." [GO_REF:0000088, GOC:rjd, GOC:TermGenie, PMID:20493808]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1905743
name: calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474]
subset: goslim_synapse
synonym: "calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie]
synonym: "mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT []
is_a: GO:0036444 ! calcium import into the mitochondrion
is_a: GO:0051649 ! establishment of localization in cell
relationship: part_of GO:0099113 ! negative regulation of presynaptic cytosolic calcium concentration

[Term]
id: GO:1905744
name: regulation of mRNA cis splicing, via spliceosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558]
synonym: "regulation of nuclear mRNA cis splicing, via spliceosome" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear mRNA cis splicing, via U2-type spliceosome" NARROW [GOC:TermGenie]
synonym: "regulation of splicing" BROAD [GOC:TermGenie]
is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome
relationship: regulates GO:0045292 ! mRNA cis splicing, via spliceosome

[Term]
id: GO:1905745
name: negative regulation of mRNA cis splicing, via spliceosome
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558]
is_a: GO:0048025 ! negative regulation of mRNA splicing, via spliceosome
is_a: GO:1905744 ! regulation of mRNA cis splicing, via spliceosome
relationship: negatively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome

[Term]
id: GO:1905746
name: positive regulation of mRNA cis splicing, via spliceosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558]
is_a: GO:0048026 ! positive regulation of mRNA splicing, via spliceosome
is_a: GO:1905744 ! regulation of mRNA cis splicing, via spliceosome
relationship: positively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome

[Term]
id: GO:1905747
name: negative regulation of saliva secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion." [GO_REF:0000058, GOC:TermGenie, PMID:23419067]
synonym: "down regulation of saliva secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of salivation" EXACT [GOC:TermGenie]
synonym: "down-regulation of saliva secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of salivation" EXACT [GOC:TermGenie]
synonym: "downregulation of saliva secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of salivation" EXACT [GOC:TermGenie]
synonym: "inhibition of saliva secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of salivation" NARROW [GOC:TermGenie]
synonym: "negative regulation of salivation" EXACT [GOC:TermGenie]
is_a: GO:0046877 ! regulation of saliva secretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060457 ! negative regulation of digestive system process
relationship: negatively_regulates GO:0046541 ! saliva secretion

[Term]
id: GO:1905748
name: hard palate morphogenesis
namespace: biological_process
def: "The developmental process by which a hard palate is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:23419067]
synonym: "palatum durum morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:1905749
name: regulation of endosome to plasma membrane protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:2001135 ! regulation of endocytic recycling
relationship: regulates GO:0099638 ! endosome to plasma membrane protein transport

[Term]
id: GO:1905750
name: negative regulation of endosome to plasma membrane protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721]
synonym: "down regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie]
synonym: "downregulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie]
synonym: "inhibition of endosome to plasma membrane protein transport" NARROW [GOC:TermGenie]
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport
is_a: GO:2001136 ! negative regulation of endocytic recycling
relationship: negatively_regulates GO:0099638 ! endosome to plasma membrane protein transport

[Term]
id: GO:1905751
name: positive regulation of endosome to plasma membrane protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721]
synonym: "activation of endosome to plasma membrane protein transport" NARROW [GOC:TermGenie]
synonym: "up regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie]
synonym: "upregulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie]
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport
is_a: GO:2001137 ! positive regulation of endocytic recycling
relationship: positively_regulates GO:0099638 ! endosome to plasma membrane protein transport

[Term]
id: GO:1905752
name: obsolete regulation of argininosuccinate synthase activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of argininosuccinate synthase activity." [GO_REF:0000059, GOC:TermGenie, PMID:19491403]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905753
name: obsolete positive regulation of argininosuccinate synthase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of argininosuccinate synthase activity." [GO_REF:0000059, GOC:TermGenie, PMID:19491403]
comment: This term was obsoleted because it represents a molecular function.
synonym: "activation of arginine succinate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of argininosuccinate synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of argininosuccinate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of argininosuccinic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of arginosuccinate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of citrulline--aspartate ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-citrulline:L-aspartate ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "positive regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905754
name: ascospore-type prospore nucleus
namespace: cellular_component
def: "Any nucleus that is part of a ascospore-type prospore." [GO_REF:0000064, GOC:TermGenie, PMID:26942678]
synonym: "cell nucleus of ascospore-type prospore" EXACT [GOC:TermGenie]
synonym: "nucleus of ascospore-type prospore" EXACT [GOC:TermGenie]
is_a: GO:0005634 ! nucleus
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:1905755
name: protein localization to cytoplasmic microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031]
synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule

[Term]
id: GO:1905756
name: regulation of primary cell septum biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700]
is_a: GO:0140279 ! regulation of mitotic division septum assembly
relationship: regulates GO:0031671 ! primary cell septum biogenesis

[Term]
id: GO:1905757
name: negative regulation of primary cell septum biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700]
is_a: GO:0140280 ! negative regulation of mitotic division septum assembly
is_a: GO:1905756 ! regulation of primary cell septum biogenesis
relationship: negatively_regulates GO:0031671 ! primary cell septum biogenesis

[Term]
id: GO:1905758
name: positive regulation of primary cell septum biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:1905756 ! regulation of primary cell septum biogenesis
relationship: positively_regulates GO:0031671 ! primary cell septum biogenesis

[Term]
id: GO:1905759
name: post-anaphase array microtubule
namespace: cellular_component
def: "Any microtubule that is part of a post-anaphase microtubule array." [GO_REF:0000064, GOC:TermGenie, PMID:11007487]
synonym: "microtubule of PAA" EXACT [GOC:TermGenie]
synonym: "microtubule of post-anaphase array" EXACT [GOC:TermGenie]
synonym: "microtubule of post-anaphase microtubule array" EXACT [GOC:TermGenie]
synonym: "microtubuli of PAA" EXACT [GOC:TermGenie]
synonym: "microtubuli of post-anaphase array" EXACT [GOC:TermGenie]
synonym: "microtubuli of post-anaphase microtubule array" EXACT [GOC:TermGenie]
synonym: "microtubulus of PAA" EXACT [GOC:TermGenie]
synonym: "microtubulus of post-anaphase array" EXACT [GOC:TermGenie]
synonym: "microtubulus of post-anaphase microtubule array" EXACT [GOC:TermGenie]
synonym: "neurotubule of PAA" NARROW [GOC:TermGenie]
synonym: "neurotubule of post-anaphase array" NARROW [GOC:TermGenie]
synonym: "neurotubule of post-anaphase microtubule array" NARROW [GOC:TermGenie]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:1990295 ! post-anaphase microtubule array

[Term]
id: GO:1905760
name: post-anaphase array microtubule end
namespace: cellular_component
def: "Any microtubule end that is part of a post-anaphase array microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487]
synonym: "microtubule end of microtubule of PAA" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubule of post-anaphase array" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubule of post-anaphase microtubule array" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubuli of PAA" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubuli of post-anaphase array" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubuli of post-anaphase microtubule array" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubulus of PAA" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubulus of post-anaphase array" EXACT [GOC:TermGenie]
synonym: "microtubule end of microtubulus of post-anaphase microtubule array" EXACT [GOC:TermGenie]
synonym: "microtubule end of neurotubule of PAA" NARROW [GOC:TermGenie]
synonym: "microtubule end of neurotubule of post-anaphase array" NARROW [GOC:TermGenie]
synonym: "microtubule end of neurotubule of post-anaphase microtubule array" NARROW [GOC:TermGenie]
synonym: "microtubule end of post-anaphase array microtubule" EXACT [GOC:TermGenie]
is_a: GO:1990752 ! microtubule end
relationship: part_of GO:1905759 ! post-anaphase array microtubule

[Term]
id: GO:1905761
name: SCF ubiquitin ligase complex binding
namespace: molecular_function
def: "Binding to a SCF ubiquitin ligase complex." [GOC:dph, GOC:ha, GOC:TermGenie, PMID:19723762]
synonym: "CDL1 complex binding" EXACT [GOC:TermGenie]
synonym: "CRL1 complex binding" EXACT [GOC:TermGenie]
synonym: "Cul1-RING ubiquitin ligase complex binding" EXACT [GOC:TermGenie]
synonym: "cullin-RING ligase 1 binding" EXACT [GOC:TermGenie]
synonym: "SCF complex binding" EXACT [GOC:TermGenie]
synonym: "SCF complex substrate recognition subunit binding" NARROW [GOC:TermGenie]
synonym: "Skp1/Cul1/F-box protein complex binding" EXACT [GOC:TermGenie]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1905762
name: CCR4-NOT complex binding
namespace: molecular_function
def: "Binding to a CCR4-NOT complex." [GOC:TermGenie, PMID:26942678]
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1905763
name: MTREC complex binding
namespace: molecular_function
def: "Binding to a MTREC complex." [GOC:TermGenie, PMID:26942678]
synonym: "Mtl1-Red1 core complex binding" EXACT [GOC:TermGenie]
synonym: "NURS complex binding" EXACT []
synonym: "PAXT complex binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1905764
name: regulation of protection from non-homologous end joining at telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602]
synonym: "regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
is_a: GO:1904353 ! regulation of telomere capping
is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage
relationship: regulates GO:0031848 ! protection from non-homologous end joining at telomere

[Term]
id: GO:1905765
name: negative regulation of protection from non-homologous end joining at telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602]
synonym: "down regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
synonym: "down regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of protection from NHEJ-mediated telomere fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of protection from non-homologous end joining at telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
is_a: GO:1904354 ! negative regulation of telomere capping
is_a: GO:1904506 ! negative regulation of telomere maintenance in response to DNA damage
is_a: GO:1905764 ! regulation of protection from non-homologous end joining at telomere
relationship: negatively_regulates GO:0031848 ! protection from non-homologous end joining at telomere

[Term]
id: GO:1905766
name: positive regulation of protection from non-homologous end joining at telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602]
synonym: "activation of protection from NHEJ-mediated telomere fusion" NARROW [GOC:TermGenie]
synonym: "activation of protection from non-homologous end joining at telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie]
is_a: GO:1904507 ! positive regulation of telomere maintenance in response to DNA damage
is_a: GO:1905764 ! regulation of protection from non-homologous end joining at telomere
relationship: positively_regulates GO:0031848 ! protection from non-homologous end joining at telomere

[Term]
id: GO:1905767
name: regulation of double-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]
subset: gocheck_do_not_annotate
is_a: GO:1904742 ! regulation of telomeric DNA binding

[Term]
id: GO:1905768
name: negative regulation of double-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]
subset: gocheck_do_not_annotate
synonym: "down regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1904743 ! negative regulation of telomeric DNA binding
is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding

[Term]
id: GO:1905769
name: positive regulation of double-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]
subset: gocheck_do_not_annotate
synonym: "activation of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
is_a: GO:1904744 ! positive regulation of telomeric DNA binding
is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding

[Term]
id: GO:1905770
name: regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0048333 ! mesodermal cell differentiation

[Term]
id: GO:1905771
name: negative regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
relationship: negatively_regulates GO:0048333 ! mesodermal cell differentiation

[Term]
id: GO:1905772
name: positive regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
relationship: positively_regulates GO:0048333 ! mesodermal cell differentiation

[Term]
id: GO:1905773
name: 8-hydroxy-2'-deoxyguanosine DNA binding
namespace: molecular_function
def: "Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA." [GO_REF:0000067, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19734539]
is_a: GO:0032357 ! oxidized purine DNA binding

[Term]
id: GO:1905774
name: regulation of DNA helicase activity
namespace: biological_process
alt_id: GO:1902449
def: "Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]
subset: gocheck_obsoletion_candidate
synonym: "regulation of ATP-dependent DNA helicase activity" EXACT []
is_a: GO:0051095 ! regulation of helicase activity
is_a: GO:1905462 ! regulation of DNA duplex unwinding

[Term]
id: GO:1905775
name: obsolete negative regulation of DNA helicase activity
namespace: biological_process
alt_id: GO:1902450
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]
comment: This term was obsoleted because it represents a molecular function.
synonym: "down regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA helicase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP-dependent DNA helicase activity" EXACT []
is_obsolete: true

[Term]
id: GO:1905776
name: positive regulation of DNA helicase activity
namespace: biological_process
alt_id: GO:1902451
def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]
subset: gocheck_obsoletion_candidate
synonym: "activation of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie]
synonym: "activation of DNA helicase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP-dependent DNA helicase activity" EXACT []
synonym: "up regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA helicase activity" EXACT [GOC:TermGenie]
is_a: GO:0051096 ! positive regulation of helicase activity
is_a: GO:1905464 ! positive regulation of DNA duplex unwinding
is_a: GO:1905774 ! regulation of DNA helicase activity

[Term]
id: GO:1905777
name: regulation of exonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]
subset: gocheck_obsoletion_candidate
synonym: "regulation of exonuclease IX activity" NARROW [GOC:TermGenie]
is_a: GO:0032069 ! regulation of nuclease activity

[Term]
id: GO:1905778
name: negative regulation of exonuclease activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of exonuclease activity" EXACT [GOC:TermGenie]
synonym: "down regulation of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of exonuclease activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "downregulation of exonuclease activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "inhibition of exonuclease activity" NARROW [GOC:TermGenie]
synonym: "inhibition of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of exonuclease IX activity" NARROW [GOC:TermGenie]
is_a: GO:0032074 ! negative regulation of nuclease activity
is_a: GO:1905777 ! regulation of exonuclease activity

[Term]
id: GO:1905779
name: positive regulation of exonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]
subset: gocheck_obsoletion_candidate
synonym: "activation of exonuclease activity" NARROW [GOC:TermGenie]
synonym: "activation of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "up regulation of exonuclease activity" EXACT [GOC:TermGenie]
synonym: "up regulation of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of exonuclease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exonuclease IX activity" NARROW [GOC:TermGenie]
synonym: "upregulation of exonuclease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exonuclease IX activity" NARROW [GOC:TermGenie]
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:1905777 ! regulation of exonuclease activity

[Term]
id: GO:1905780
name: regulation of phosphatidylserine exposure on apoptotic cell surface
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362]
synonym: "regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
is_a: GO:0061091 ! regulation of phospholipid translocation
is_a: GO:1903729 ! regulation of plasma membrane organization
relationship: regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface

[Term]
id: GO:1905781
name: negative regulation of phosphatidylserine exposure on apoptotic cell surface
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362]
synonym: "down regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie]
synonym: "down-regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie]
synonym: "downregulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie]
synonym: "inhibition of externalization of phosphatidylserine" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine exposure on apoptotic cell surface" NARROW [GOC:TermGenie]
synonym: "negative regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
is_a: GO:0061093 ! negative regulation of phospholipid translocation
is_a: GO:1900118 ! negative regulation of execution phase of apoptosis
is_a: GO:1905780 ! regulation of phosphatidylserine exposure on apoptotic cell surface
relationship: negatively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface

[Term]
id: GO:1905782
name: positive regulation of phosphatidylserine exposure on apoptotic cell surface
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362]
synonym: "activation of externalization of phosphatidylserine" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine exposure on apoptotic cell surface" NARROW [GOC:TermGenie]
synonym: "positive regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
synonym: "up regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie]
synonym: "up-regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie]
synonym: "upregulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie]
is_a: GO:0061092 ! positive regulation of phospholipid translocation
is_a: GO:1905780 ! regulation of phosphatidylserine exposure on apoptotic cell surface
relationship: positively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface

[Term]
id: GO:1905783
name: obsolete CENP-A containing nucleosome disassembly
namespace: biological_process
def: "OBSOLETE. The disaggregation of a CENP-A containing nucleosome into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:27666591]
comment: This term was obsoleted because it did not describe a different process from that described by its parent.
synonym: "centromere specific nucleosome disassembly" RELATED [GOC:TermGenie]
synonym: "centromere-specific nucleosome disassembly" RELATED [GOC:TermGenie]
synonym: "centromeric nucleosome disassembly" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0006337

[Term]
id: GO:1905784
name: regulation of anaphase-promoting complex-dependent catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876]
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
relationship: regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process

[Term]
id: GO:1905785
name: negative regulation of anaphase-promoting complex-dependent catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876]
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1905784 ! regulation of anaphase-promoting complex-dependent catabolic process
relationship: negatively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process

[Term]
id: GO:1905786
name: positive regulation of anaphase-promoting complex-dependent catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1905784 ! regulation of anaphase-promoting complex-dependent catabolic process
relationship: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process

[Term]
id: GO:1905787
name: regulation of detection of mechanical stimulus involved in sensory perception of touch
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859]
synonym: "regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0051931 ! regulation of sensory perception
relationship: regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch

[Term]
id: GO:1905788
name: negative regulation of detection of mechanical stimulus involved in sensory perception of touch
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859]
synonym: "down regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie]
synonym: "down regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "down regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "down regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie]
synonym: "down-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "down-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie]
synonym: "downregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "downregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie]
synonym: "inhibition of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie]
synonym: "inhibition of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "negative regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "negative regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch
relationship: negatively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch

[Term]
id: GO:1905789
name: positive regulation of detection of mechanical stimulus involved in sensory perception of touch
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859]
synonym: "activation of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie]
synonym: "activation of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "activation of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "activation of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "activation of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie]
synonym: "activation of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie]
synonym: "activation of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "positive regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "positive regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie]
synonym: "up regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "up regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie]
synonym: "up-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "up-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie]
synonym: "upregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie]
synonym: "upregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch
relationship: positively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch

[Term]
id: GO:1905790
name: regulation of mechanosensory behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859]
synonym: "regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0007638 ! mechanosensory behavior

[Term]
id: GO:1905791
name: negative regulation of mechanosensory behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859]
synonym: "down regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of mechanosensory behavior" EXACT [GOC:TermGenie]
synonym: "down regulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
synonym: "down-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of mechanosensory behavior" EXACT [GOC:TermGenie]
synonym: "down-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
synonym: "downregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of mechanosensory behavior" EXACT [GOC:TermGenie]
synonym: "downregulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
synonym: "inhibition of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of mechanosensory behavior" NARROW [GOC:TermGenie]
synonym: "inhibition of mechanosensory behaviour" NARROW [GOC:TermGenie]
synonym: "negative regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1905790 ! regulation of mechanosensory behavior
relationship: negatively_regulates GO:0007638 ! mechanosensory behavior

[Term]
id: GO:1905792
name: positive regulation of mechanosensory behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859]
synonym: "activation of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "activation of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie]
synonym: "activation of mechanosensory behavior" NARROW [GOC:TermGenie]
synonym: "activation of mechanosensory behaviour" NARROW [GOC:TermGenie]
synonym: "positive regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
synonym: "up regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of mechanosensory behavior" EXACT [GOC:TermGenie]
synonym: "up regulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
synonym: "up-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of mechanosensory behavior" EXACT [GOC:TermGenie]
synonym: "up-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
synonym: "upregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of mechanosensory behavior" EXACT [GOC:TermGenie]
synonym: "upregulation of mechanosensory behaviour" EXACT [GOC:TermGenie]
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1905790 ! regulation of mechanosensory behavior
relationship: positively_regulates GO:0007638 ! mechanosensory behavior

[Term]
id: GO:1905793
name: protein localization to pericentriolar material
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a pericentriolar material." [GO_REF:0000087, GOC:TermGenie, PMID:21694707, PMID:24385583]
synonym: "protein localisation in pericentriolar material" EXACT [GOC:TermGenie]
synonym: "protein localisation to pericentriolar material" EXACT [GOC:TermGenie]
synonym: "protein localization in pericentriolar material" EXACT [GOC:TermGenie]
is_a: GO:0071539 ! protein localization to centrosome

[Term]
id: GO:1905794
name: response to puromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288]
synonym: "response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT []
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905795
name: cellular response to puromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288]
synonym: "cellular response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905794 ! response to puromycin

[Term]
id: GO:1905796
name: regulation of intraciliary anterograde transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654]
synonym: "regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0035720 ! intraciliary anterograde transport

[Term]
id: GO:1905797
name: negative regulation of intraciliary anterograde transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654]
synonym: "down regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie]
synonym: "down regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
synonym: "downregulation of intraciliary anterograde transport" EXACT [GOC:TermGenie]
synonym: "downregulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
synonym: "inhibition of intraciliary anterograde transport" NARROW [GOC:TermGenie]
synonym: "inhibition of intraflagellar anterograde transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1905796 ! regulation of intraciliary anterograde transport
relationship: negatively_regulates GO:0035720 ! intraciliary anterograde transport

[Term]
id: GO:1905798
name: positive regulation of intraciliary anterograde transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654]
synonym: "activation of intraciliary anterograde transport" NARROW [GOC:TermGenie]
synonym: "activation of intraflagellar anterograde transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
synonym: "up regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie]
synonym: "up regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
synonym: "upregulation of intraciliary anterograde transport" EXACT [GOC:TermGenie]
synonym: "upregulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1905796 ! regulation of intraciliary anterograde transport
relationship: positively_regulates GO:0035720 ! intraciliary anterograde transport

[Term]
id: GO:1905799
name: regulation of intraciliary retrograde transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654]
synonym: "regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0035721 ! intraciliary retrograde transport

[Term]
id: GO:1905800
name: negative regulation of intraciliary retrograde transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654]
synonym: "down regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie]
synonym: "down regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
synonym: "downregulation of intraciliary retrograde transport" EXACT [GOC:TermGenie]
synonym: "downregulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
synonym: "inhibition of intraciliary retrograde transport" NARROW [GOC:TermGenie]
synonym: "inhibition of intraflagellar retrograde transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1905799 ! regulation of intraciliary retrograde transport
relationship: negatively_regulates GO:0035721 ! intraciliary retrograde transport

[Term]
id: GO:1905801
name: positive regulation of intraciliary retrograde transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654]
synonym: "activation of intraciliary retrograde transport" NARROW [GOC:TermGenie]
synonym: "activation of intraflagellar retrograde transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
synonym: "up regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie]
synonym: "up regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
synonym: "upregulation of intraciliary retrograde transport" EXACT [GOC:TermGenie]
synonym: "upregulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1905799 ! regulation of intraciliary retrograde transport
relationship: positively_regulates GO:0035721 ! intraciliary retrograde transport

[Term]
id: GO:1905802
name: regulation of cellular response to manganese ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876]
synonym: "regulation of cellular response to manganese" EXACT [GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0071287 ! cellular response to manganese ion

[Term]
id: GO:1905803
name: negative regulation of cellular response to manganese ion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876]
synonym: "down regulation of cellular response to manganese" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to manganese ion" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to manganese" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to manganese ion" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to manganese" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to manganese ion" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to manganese" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to manganese ion" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to manganese" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1905802 ! regulation of cellular response to manganese ion
relationship: negatively_regulates GO:0071287 ! cellular response to manganese ion

[Term]
id: GO:1905804
name: positive regulation of cellular response to manganese ion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876]
synonym: "activation of cellular response to manganese" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to manganese ion" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular response to manganese" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to manganese" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to manganese ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to manganese" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to manganese ion" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to manganese" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to manganese ion" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1905802 ! regulation of cellular response to manganese ion
relationship: positively_regulates GO:0071287 ! cellular response to manganese ion

[Term]
id: GO:1905805
name: excitatory synapse pruning
namespace: biological_process
def: "The disaggregation of an excitatory synapse into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:27779093]
synonym: "synapse clearance" BROAD []
synonym: "synapse disassembly" BROAD []
synonym: "synapse elimination" BROAD []
synonym: "synapse removal" BROAD []
is_a: GO:0098883 ! synapse pruning

[Term]
id: GO:1905806
name: regulation of synapse pruning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
subset: goslim_synapse
synonym: "regulation of synapse clearance" EXACT []
synonym: "regulation of synapse disassembly" EXACT syngo_official_label []
synonym: "regulation of synapse elimination" EXACT []
synonym: "regulation of synapse removal" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
relationship: regulates GO:0098883 ! synapse pruning

[Term]
id: GO:1905807
name: negative regulation of synapse pruning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
is_a: GO:1905806 ! regulation of synapse pruning
is_a: GO:1905809 ! negative regulation of synapse organization
relationship: negatively_regulates GO:0098883 ! synapse pruning

[Term]
id: GO:1905808
name: positive regulation of synapse pruning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905806 ! regulation of synapse pruning
relationship: positively_regulates GO:0098883 ! synapse pruning

[Term]
id: GO:1905809
name: negative regulation of synapse organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of synapse development" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of synapse development" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0050808 ! synapse organization

[Term]
id: GO:1905810
name: regulation of excitatory synapse pruning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
is_a: GO:1905806 ! regulation of synapse pruning
relationship: regulates GO:1905805 ! excitatory synapse pruning

[Term]
id: GO:1905811
name: negative regulation of excitatory synapse pruning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of excitatory synapse disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of excitatory synapse disassembly" NARROW [GOC:TermGenie]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
is_a: GO:1905807 ! negative regulation of synapse pruning
is_a: GO:1905810 ! regulation of excitatory synapse pruning
relationship: negatively_regulates GO:1905805 ! excitatory synapse pruning

[Term]
id: GO:1905812
name: regulation of motor neuron axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533]
synonym: "regulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "regulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "regulation of motor axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:1902667 ! regulation of axon guidance
relationship: regulates GO:0008045 ! motor neuron axon guidance

[Term]
id: GO:1905813
name: negative regulation of motor neuron axon guidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533]
synonym: "down regulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of motor axon pathfinding" EXACT [GOC:TermGenie]
synonym: "down regulation of motor neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of motor axon pathfinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of motor neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of motor axon pathfinding" EXACT [GOC:TermGenie]
synonym: "downregulation of motor neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "inhibition of motoneuron axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of motor axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of motor axon pathfinding" NARROW [GOC:TermGenie]
synonym: "inhibition of motor neuron axon guidance" NARROW [GOC:TermGenie]
synonym: "negative regulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "negative regulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "negative regulation of motor axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:1902668 ! negative regulation of axon guidance
is_a: GO:1905812 ! regulation of motor neuron axon guidance
relationship: negatively_regulates GO:0008045 ! motor neuron axon guidance

[Term]
id: GO:1905814
name: positive regulation of motor neuron axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533]
synonym: "activation of motoneuron axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of motor axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of motor axon pathfinding" NARROW [GOC:TermGenie]
synonym: "activation of motor neuron axon guidance" NARROW [GOC:TermGenie]
synonym: "positive regulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "positive regulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "positive regulation of motor axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of motor axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of motor neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of motor axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of motor neuron axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of motoneuron axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of motor axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of motor axon pathfinding" EXACT [GOC:TermGenie]
synonym: "upregulation of motor neuron axon guidance" EXACT [GOC:TermGenie]
is_a: GO:1902669 ! positive regulation of axon guidance
is_a: GO:1905812 ! regulation of motor neuron axon guidance
relationship: positively_regulates GO:0008045 ! motor neuron axon guidance

[Term]
id: GO:1905815
name: regulation of dorsal/ventral axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533]
synonym: "regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
is_a: GO:1902667 ! regulation of axon guidance
relationship: regulates GO:0033563 ! dorsal/ventral axon guidance

[Term]
id: GO:1905816
name: negative regulation of dorsal/ventral axon guidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533]
synonym: "down regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "down regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "downregulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
synonym: "inhibition of dorsal-ventral axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of dorsal/ventral axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of dorsal/ventral axon pathfinding" NARROW [GOC:TermGenie]
synonym: "inhibition of dorsoventral axon guidance" NARROW [GOC:TermGenie]
synonym: "negative regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "negative regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "negative regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
is_a: GO:1902668 ! negative regulation of axon guidance
is_a: GO:1905815 ! regulation of dorsal/ventral axon guidance
relationship: negatively_regulates GO:0033563 ! dorsal/ventral axon guidance

[Term]
id: GO:1905817
name: positive regulation of dorsal/ventral axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533]
synonym: "activation of dorsal-ventral axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of dorsal/ventral axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of dorsal/ventral axon pathfinding" NARROW [GOC:TermGenie]
synonym: "activation of dorsoventral axon guidance" NARROW [GOC:TermGenie]
synonym: "positive regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "positive regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "positive regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie]
synonym: "upregulation of dorsoventral axon guidance" EXACT [GOC:TermGenie]
is_a: GO:1902669 ! positive regulation of axon guidance
is_a: GO:1905815 ! regulation of dorsal/ventral axon guidance
relationship: positively_regulates GO:0033563 ! dorsal/ventral axon guidance

[Term]
id: GO:1905818
name: regulation of chromosome separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]
synonym: "regulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "regulation of rDNA separation" NARROW [GOC:TermGenie]
is_a: GO:0051983 ! regulation of chromosome segregation
relationship: regulates GO:0051304 ! chromosome separation

[Term]
id: GO:1905819
name: negative regulation of chromosome separation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]
synonym: "down regulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "down regulation of chromosome separation" EXACT [GOC:TermGenie]
synonym: "down regulation of rDNA separation" NARROW [GOC:TermGenie]
synonym: "down-regulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "down-regulation of chromosome separation" EXACT [GOC:TermGenie]
synonym: "down-regulation of rDNA separation" NARROW [GOC:TermGenie]
synonym: "downregulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "downregulation of chromosome separation" EXACT [GOC:TermGenie]
synonym: "downregulation of rDNA separation" NARROW [GOC:TermGenie]
synonym: "inhibition of chromatid release" RELATED [GOC:TermGenie]
synonym: "inhibition of chromosome separation" NARROW [GOC:TermGenie]
synonym: "inhibition of rDNA separation" NARROW [GOC:TermGenie]
synonym: "negative regulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "negative regulation of rDNA separation" NARROW [GOC:TermGenie]
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:1905818 ! regulation of chromosome separation
relationship: negatively_regulates GO:0051304 ! chromosome separation

[Term]
id: GO:1905820
name: positive regulation of chromosome separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]
synonym: "activation of chromatid release" RELATED [GOC:TermGenie]
synonym: "activation of chromosome separation" NARROW [GOC:TermGenie]
synonym: "activation of rDNA separation" NARROW [GOC:TermGenie]
synonym: "positive regulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "positive regulation of rDNA separation" NARROW [GOC:TermGenie]
synonym: "up regulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "up regulation of chromosome separation" EXACT [GOC:TermGenie]
synonym: "up regulation of rDNA separation" NARROW [GOC:TermGenie]
synonym: "up-regulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "up-regulation of chromosome separation" EXACT [GOC:TermGenie]
synonym: "up-regulation of rDNA separation" NARROW [GOC:TermGenie]
synonym: "upregulation of chromatid release" RELATED [GOC:TermGenie]
synonym: "upregulation of chromosome separation" EXACT [GOC:TermGenie]
synonym: "upregulation of rDNA separation" NARROW [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1905818 ! regulation of chromosome separation
relationship: positively_regulates GO:0051304 ! chromosome separation

[Term]
id: GO:1905821
name: positive regulation of chromosome condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547]
synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie]
synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie]
synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0060623 ! regulation of chromosome condensation
is_a: GO:2001252 ! positive regulation of chromosome organization
relationship: positively_regulates GO:0030261 ! chromosome condensation

[Term]
id: GO:1905822
name: regulation of mitotic sister chromatid arm separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790]
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
relationship: regulates GO:1990891 ! mitotic sister chromatid arm separation

[Term]
id: GO:1905823
name: negative regulation of mitotic sister chromatid arm separation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790]
synonym: "down regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic sister chromatid arm separation" NARROW [GOC:TermGenie]
is_a: GO:1905822 ! regulation of mitotic sister chromatid arm separation
is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation
relationship: negatively_regulates GO:1990891 ! mitotic sister chromatid arm separation

[Term]
id: GO:1905824
name: positive regulation of mitotic sister chromatid arm separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790]
synonym: "activation of mitotic sister chromatid arm separation" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie]
is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation
is_a: GO:1905822 ! regulation of mitotic sister chromatid arm separation
relationship: positively_regulates GO:1990891 ! mitotic sister chromatid arm separation

[Term]
id: GO:1905825
name: regulation of selenocysteine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792]
synonym: "regulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0016259 ! selenocysteine metabolic process

[Term]
id: GO:1905826
name: negative regulation of selenocysteine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792]
synonym: "down regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of selenocysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of selenocysteine metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of selenocysteine metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1905825 ! regulation of selenocysteine metabolic process
relationship: negatively_regulates GO:0016259 ! selenocysteine metabolic process

[Term]
id: GO:1905827
name: positive regulation of selenocysteine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792]
synonym: "activation of selenocysteine metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of selenocysteine metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of selenocysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of selenocysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1905825 ! regulation of selenocysteine metabolic process
relationship: positively_regulates GO:0016259 ! selenocysteine metabolic process

[Term]
id: GO:1905828
name: regulation of prostaglandin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938]
synonym: "regulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of prostaglandin degradation" EXACT [GOC:TermGenie]
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:1905344 ! prostaglandin catabolic process

[Term]
id: GO:1905829
name: negative regulation of prostaglandin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938]
synonym: "down regulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of prostaglandin degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of prostaglandin degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of prostaglandin catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of prostaglandin degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of prostaglandin breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of prostaglandin catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of prostaglandin catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of prostaglandin degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of prostaglandin degradation" EXACT [GOC:TermGenie]
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:1905828 ! regulation of prostaglandin catabolic process
relationship: negatively_regulates GO:1905344 ! prostaglandin catabolic process

[Term]
id: GO:1905830
name: positive regulation of prostaglandin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938]
synonym: "activation of prostaglandin breakdown" NARROW [GOC:TermGenie]
synonym: "activation of prostaglandin catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of prostaglandin catabolism" NARROW [GOC:TermGenie]
synonym: "activation of prostaglandin degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of prostaglandin degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of prostaglandin degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of prostaglandin degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of prostaglandin breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of prostaglandin catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of prostaglandin catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of prostaglandin degradation" EXACT [GOC:TermGenie]
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:1905828 ! regulation of prostaglandin catabolic process
relationship: positively_regulates GO:1905344 ! prostaglandin catabolic process

[Term]
id: GO:1905831
name: negative regulation of spindle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799]
synonym: "down regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "down regulation of spindle assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of spindle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spindle assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of spindle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of spindle assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of spindle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of bipolar spindle biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of bipolar spindle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of spindle assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of spindle biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of spindle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of spindle formation" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0090169 ! regulation of spindle assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
relationship: negatively_regulates GO:0051225 ! spindle assembly

[Term]
id: GO:1905832
name: positive regulation of spindle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799]
synonym: "activation of bipolar spindle biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of bipolar spindle formation" NARROW [GOC:TermGenie]
synonym: "activation of spindle assembly" NARROW [GOC:TermGenie]
synonym: "activation of spindle biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of spindle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of bipolar spindle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle formation" EXACT [GOC:TermGenie]
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:0090169 ! regulation of spindle assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
relationship: positively_regulates GO:0051225 ! spindle assembly

[Term]
id: GO:1905833
name: negative regulation of microtubule nucleation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799]
synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031115 ! negative regulation of microtubule polymerization
relationship: negatively_regulates GO:0007020 ! microtubule nucleation

[Term]
id: GO:1905834
name: response to pyrimidine ribonucleotide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22065602]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1905835
name: cellular response to pyrimidine ribonucleotide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22065602]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905834 ! response to pyrimidine ribonucleotide

[Term]
id: GO:1905836
name: response to triterpenoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:28078994]
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:1905837
name: cellular response to triterpenoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:28078994]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1905836 ! response to triterpenoid

[Term]
id: GO:1905838
name: regulation of telomeric D-loop disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]
is_a: GO:1904533 ! regulation of telomeric loop disassembly
relationship: regulates GO:0061820 ! telomeric D-loop disassembly

[Term]
id: GO:1905839
name: negative regulation of telomeric D-loop disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]
synonym: "down regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of telomeric D-loop disassembly" NARROW [GOC:TermGenie]
is_a: GO:1904534 ! negative regulation of telomeric loop disassembly
is_a: GO:1905838 ! regulation of telomeric D-loop disassembly
relationship: negatively_regulates GO:0061820 ! telomeric D-loop disassembly

[Term]
id: GO:1905840
name: positive regulation of telomeric D-loop disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]
synonym: "activation of telomeric D-loop disassembly" NARROW [GOC:TermGenie]
synonym: "up regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie]
is_a: GO:1904535 ! positive regulation of telomeric loop disassembly
is_a: GO:1905838 ! regulation of telomeric D-loop disassembly
relationship: positively_regulates GO:0061820 ! telomeric D-loop disassembly

[Term]
id: GO:1905841
name: response to oxidopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876]
is_a: GO:0071869 ! response to catecholamine

[Term]
id: GO:1905842
name: cellular response to oxidopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:1905841 ! response to oxidopamine

[Term]
id: GO:1905843
name: regulation of cellular response to gamma radiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386]
synonym: "regulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:2001228 ! regulation of response to gamma radiation
relationship: regulates GO:0071480 ! cellular response to gamma radiation

[Term]
id: GO:1905844
name: negative regulation of cellular response to gamma radiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386]
synonym: "down regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular response to gamma radiation" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "negative regulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "negative regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1905843 ! regulation of cellular response to gamma radiation
is_a: GO:2001229 ! negative regulation of response to gamma radiation
relationship: negatively_regulates GO:0071480 ! cellular response to gamma radiation

[Term]
id: GO:1905845
name: positive regulation of cellular response to gamma radiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386]
synonym: "activation of cellular response to gamma radiation" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "activation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "positive regulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "positive regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to gamma ray" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1905843 ! regulation of cellular response to gamma radiation
is_a: GO:2001230 ! positive regulation of response to gamma radiation
relationship: positively_regulates GO:0071480 ! cellular response to gamma radiation

[Term]
id: GO:1905846
name: regulation of cellular response to oxidopamine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:1905842 ! cellular response to oxidopamine

[Term]
id: GO:1905847
name: negative regulation of cellular response to oxidopamine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876]
synonym: "down regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to oxidopamine" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to oxidopamine" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1905846 ! regulation of cellular response to oxidopamine
relationship: negatively_regulates GO:1905842 ! cellular response to oxidopamine

[Term]
id: GO:1905848
name: positive regulation of cellular response to oxidopamine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876]
synonym: "activation of cellular response to oxidopamine" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to oxidopamine" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1905846 ! regulation of cellular response to oxidopamine
relationship: positively_regulates GO:1905842 ! cellular response to oxidopamine

[Term]
id: GO:1905849
name: negative regulation of forward locomotion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of forward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360]
synonym: "down regulation of forward locomotion" EXACT [GOC:TermGenie]
synonym: "down-regulation of forward locomotion" EXACT [GOC:TermGenie]
synonym: "downregulation of forward locomotion" EXACT [GOC:TermGenie]
synonym: "inhibition of forward locomotion" NARROW [GOC:TermGenie]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0043059 ! regulation of forward locomotion
relationship: negatively_regulates GO:0043056 ! forward locomotion

[Term]
id: GO:1905850
name: positive regulation of forward locomotion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of forward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360]
synonym: "activation of forward locomotion" NARROW [GOC:TermGenie]
synonym: "up regulation of forward locomotion" EXACT [GOC:TermGenie]
synonym: "up-regulation of forward locomotion" EXACT [GOC:TermGenie]
synonym: "upregulation of forward locomotion" EXACT [GOC:TermGenie]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0043059 ! regulation of forward locomotion
relationship: positively_regulates GO:0043056 ! forward locomotion

[Term]
id: GO:1905851
name: negative regulation of backward locomotion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of backward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360]
synonym: "down regulation of backward locomotion" EXACT [GOC:TermGenie]
synonym: "down-regulation of backward locomotion" EXACT [GOC:TermGenie]
synonym: "downregulation of backward locomotion" EXACT [GOC:TermGenie]
synonym: "inhibition of backward locomotion" NARROW [GOC:TermGenie]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0043058 ! regulation of backward locomotion
relationship: negatively_regulates GO:0043057 ! backward locomotion

[Term]
id: GO:1905852
name: positive regulation of backward locomotion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of backward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360]
synonym: "activation of backward locomotion" NARROW [GOC:TermGenie]
synonym: "up regulation of backward locomotion" EXACT [GOC:TermGenie]
synonym: "up-regulation of backward locomotion" EXACT [GOC:TermGenie]
synonym: "upregulation of backward locomotion" EXACT [GOC:TermGenie]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0043058 ! regulation of backward locomotion
relationship: positively_regulates GO:0043057 ! backward locomotion

[Term]
id: GO:1905853
name: regulation of heparan sulfate binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:1905854
name: negative regulation of heparan sulfate binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "down regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "downregulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "inhibition of heparan sulfate binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1905853 ! regulation of heparan sulfate binding

[Term]
id: GO:1905855
name: positive regulation of heparan sulfate binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "activation of heparan sulfate binding" NARROW [GOC:TermGenie]
synonym: "up regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "upregulation of heparan sulfate binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1905853 ! regulation of heparan sulfate binding

[Term]
id: GO:1905856
name: negative regulation of pentose-phosphate shunt
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt." [GO_REF:0000058, GOC:TermGenie, PMID:19015259]
is_a: GO:0043456 ! regulation of pentose-phosphate shunt
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
relationship: negatively_regulates GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:1905857
name: positive regulation of pentose-phosphate shunt
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt." [GO_REF:0000058, GOC:TermGenie, PMID:19015259]
is_a: GO:0043456 ! regulation of pentose-phosphate shunt
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
relationship: positively_regulates GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:1905858
name: regulation of heparan sulfate proteoglycan binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:1905859
name: negative regulation of heparan sulfate proteoglycan binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "down regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "down regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "down-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "downregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "downregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "inhibition of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie]
synonym: "inhibition of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "negative regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding

[Term]
id: GO:1905860
name: positive regulation of heparan sulfate proteoglycan binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "activation of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie]
synonym: "activation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "positive regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "up regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "up regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "up-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "upregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "upregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding

[Term]
id: GO:1905861
name: intranuclear rod assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an intranuclear rod." [GO_REF:0000079, GOC:TermGenie, PMID:28074884]
synonym: "intranuclear actin rod assembly" EXACT [GOC:TermGenie]
synonym: "intranuclear actin rod formation" EXACT [GOC:TermGenie]
synonym: "intranuclear rod formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:1905862
name: ferroxidase complex
namespace: cellular_component
def: "A protein complex which is capable of ferroxidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16522632]
comment: An example of this is FET3 in Saccharomyces cerevisiae (P38993) in PMID:16522632 (inferred from direct assay).
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1905863
name: obsolete invadopodium organization
namespace: biological_process
def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an invadopodium." [GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
is_obsolete: true

[Term]
id: GO:1905864
name: regulation of Atg1/ULK1 kinase complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215]
synonym: "regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly

[Term]
id: GO:1905865
name: negative regulation of Atg1/ULK1 kinase complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215]
synonym: "down regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ATG1 kinase complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of ATG1 kinase complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of Atg1p signalling complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Atg1p signalling complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ULK1 signaling complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of ULK1 signaling complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly
relationship: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly

[Term]
id: GO:1905866
name: positive regulation of Atg1/ULK1 kinase complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215]
synonym: "activation of ATG1 kinase complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of ATG1 kinase complex formation" NARROW [GOC:TermGenie]
synonym: "activation of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie]
synonym: "activation of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie]
synonym: "activation of Atg1p signalling complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Atg1p signalling complex formation" NARROW [GOC:TermGenie]
synonym: "activation of ULK1 signaling complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of ULK1 signaling complex formation" NARROW [GOC:TermGenie]
synonym: "activation of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly
relationship: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly

[Term]
id: GO:1905867
name: epididymis development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12388089]
synonym: "epididymus development" EXACT [GOC:TermGenie]
is_a: GO:0035295 ! tube development

[Term]
id: GO:1905868
name: regulation of 3'-UTR-mediated mRNA stabilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525]
synonym: "regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
is_a: GO:0043488 ! regulation of mRNA stability
relationship: regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization

[Term]
id: GO:1905869
name: negative regulation of 3'-UTR-mediated mRNA stabilization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525]
synonym: "down regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "down regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "down-regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "down-regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "downregulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "downregulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "inhibition of 3'-untranslated region-mediated mRNA stabilization" NARROW [GOC:TermGenie]
synonym: "inhibition of 3'-UTR-mediated mRNA stabilization" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:1905868 ! regulation of 3'-UTR-mediated mRNA stabilization
relationship: negatively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization

[Term]
id: GO:1905870
name: positive regulation of 3'-UTR-mediated mRNA stabilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525]
synonym: "activation of 3'-untranslated region-mediated mRNA stabilization" NARROW [GOC:TermGenie]
synonym: "activation of 3'-UTR-mediated mRNA stabilization" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "up regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "up regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "upregulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie]
synonym: "upregulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:1905868 ! regulation of 3'-UTR-mediated mRNA stabilization
relationship: positively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization

[Term]
id: GO:1905871
name: regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:1902463 ! protein localization to cell leading edge

[Term]
id: GO:1905872
name: negative regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905871 ! regulation of protein localization to cell leading edge
relationship: negatively_regulates GO:1902463 ! protein localization to cell leading edge

[Term]
id: GO:1905873
name: positive regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905871 ! regulation of protein localization to cell leading edge
relationship: positively_regulates GO:1902463 ! protein localization to cell leading edge

[Term]
id: GO:1905874
name: regulation of postsynaptic density organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379]
synonym: "regulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "regulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "regulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "regulation of PSD organization" EXACT [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0099175 ! regulation of postsynapse organization
relationship: regulates GO:0097106 ! postsynaptic density organization

[Term]
id: GO:1905875
name: negative regulation of postsynaptic density organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379]
synonym: "down regulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "down regulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "down regulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of postsynaptic density organization" EXACT [GOC:TermGenie]
synonym: "down regulation of PSD organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic density organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of PSD organization" EXACT [GOC:TermGenie]
synonym: "downregulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "downregulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic density organization" EXACT [GOC:TermGenie]
synonym: "downregulation of PSD organization" EXACT [GOC:TermGenie]
synonym: "inhibition of post synaptic density organization" NARROW [GOC:TermGenie]
synonym: "inhibition of post-synaptic density organization" NARROW [GOC:TermGenie]
synonym: "inhibition of postsynaptic density organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of postsynaptic density organization" NARROW [GOC:TermGenie]
synonym: "inhibition of PSD organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of PSD organization" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1905874 ! regulation of postsynaptic density organization
relationship: negatively_regulates GO:0097106 ! postsynaptic density organization

[Term]
id: GO:1905876
name: positive regulation of postsynaptic density organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379]
synonym: "activation of post synaptic density organization" NARROW [GOC:TermGenie]
synonym: "activation of post-synaptic density organization" NARROW [GOC:TermGenie]
synonym: "activation of postsynaptic density organisation" NARROW [GOC:TermGenie]
synonym: "activation of postsynaptic density organization" NARROW [GOC:TermGenie]
synonym: "activation of PSD organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of PSD organization" EXACT [GOC:TermGenie]
synonym: "up regulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "up regulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic density organization" EXACT [GOC:TermGenie]
synonym: "up regulation of PSD organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic density organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of PSD organization" EXACT [GOC:TermGenie]
synonym: "upregulation of post synaptic density organization" EXACT [GOC:TermGenie]
synonym: "upregulation of post-synaptic density organization" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic density organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic density organization" EXACT [GOC:TermGenie]
synonym: "upregulation of PSD organization" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1905874 ! regulation of postsynaptic density organization
relationship: positively_regulates GO:0097106 ! postsynaptic density organization

[Term]
id: GO:1905877
name: obsolete invadopodium assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form an invadopodium." [GO_REF:0000079, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
synonym: "invadopodium formation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905878
name: obsolete invadopodium disassembly
namespace: biological_process
def: "OBSOLETE. The disaggregation of an invadopodium into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
is_obsolete: true

[Term]
id: GO:1905879
name: regulation of oogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "regulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0048477 ! oogenesis

[Term]
id: GO:1905880
name: negative regulation of oogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ovum development" EXACT [GOC:TermGenie]
synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ovum development" NARROW [GOC:TermGenie]
synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905879 ! regulation of oogenesis
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0048477 ! oogenesis

[Term]
id: GO:1905881
name: positive regulation of oogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "activation of oogenesis" NARROW [GOC:TermGenie]
synonym: "activation of ovum development" NARROW [GOC:TermGenie]
synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905879 ! regulation of oogenesis
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0048477 ! oogenesis

[Term]
id: GO:1905882
name: obsolete other organism cell wall
namespace: cellular_component
def: "OBSOLETE. Any cell wall that is part of a other organism." [GO_REF:0000064, GOC:TermGenie, PMID:12438152]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1905883
name: regulation of triglyceride transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533]
synonym: "regulation of triacylglycerol transport" EXACT [GOC:TermGenie]
is_a: GO:1901506 ! regulation of acylglycerol transport
relationship: regulates GO:0034197 ! triglyceride transport

[Term]
id: GO:1905884
name: negative regulation of triglyceride transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533]
synonym: "down regulation of triacylglycerol transport" EXACT [GOC:TermGenie]
synonym: "down regulation of triglyceride transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of triacylglycerol transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of triglyceride transport" EXACT [GOC:TermGenie]
synonym: "downregulation of triacylglycerol transport" EXACT [GOC:TermGenie]
synonym: "downregulation of triglyceride transport" EXACT [GOC:TermGenie]
synonym: "inhibition of triacylglycerol transport" NARROW [GOC:TermGenie]
synonym: "inhibition of triglyceride transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of triacylglycerol transport" EXACT [GOC:TermGenie]
is_a: GO:1901507 ! negative regulation of acylglycerol transport
is_a: GO:1905883 ! regulation of triglyceride transport
relationship: negatively_regulates GO:0034197 ! triglyceride transport

[Term]
id: GO:1905885
name: positive regulation of triglyceride transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533]
synonym: "activation of triacylglycerol transport" NARROW [GOC:TermGenie]
synonym: "activation of triglyceride transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of triacylglycerol transport" EXACT [GOC:TermGenie]
synonym: "up regulation of triacylglycerol transport" EXACT [GOC:TermGenie]
synonym: "up regulation of triglyceride transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of triacylglycerol transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of triglyceride transport" EXACT [GOC:TermGenie]
synonym: "upregulation of triacylglycerol transport" EXACT [GOC:TermGenie]
synonym: "upregulation of triglyceride transport" EXACT [GOC:TermGenie]
is_a: GO:1901508 ! positive regulation of acylglycerol transport
is_a: GO:1905883 ! regulation of triglyceride transport
relationship: positively_regulates GO:0034197 ! triglyceride transport

[Term]
id: GO:1905886
name: obsolete chromatin remodeling involved in meiosis I
namespace: biological_process
def: "OBSOLETE. Any chromatin remodeling that is involved in meiosis I." [GO_REF:0000060, GOC:TermGenie, PMID:19139281, PMID:25934010, PMID:9106659]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "chromatin modeling involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "chromatin modelling involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "chromatin remodelling involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "meiosis-specific chromatin remodeling" EXACT [PMID:19139281]
is_obsolete: true

[Term]
id: GO:1905887
name: autoinducer AI-2 transmembrane transport
namespace: biological_process
def: "The process in which (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol (autoinducer AI-2) is transported across a membrane. AI-2 is produced by prokaryotes and is believed to play a role in quorum sensing." [GO_REF:0000069, GOC:TermGenie, PMID:15601708]
synonym: "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol transmembrane transport" EXACT [PMID:15601708]
synonym: "AI-2 transmembrane transport" EXACT [PMID:15601708]
synonym: "autoinducer 2 transmembrane transport" EXACT [PMID:15601708]
is_a: GO:0015791 ! polyol transmembrane transport

[Term]
id: GO:1905888
name: negative regulation of cellular response to very-low-density lipoprotein particle stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957]
synonym: "down regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to very-low-density lipoprotein particle stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to VLDL particle stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1905890 ! regulation of cellular response to very-low-density lipoprotein particle stimulus
relationship: negatively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus

[Term]
id: GO:1905889
name: positive regulation of cellular response to very-low-density lipoprotein particle stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957]
synonym: "activation of cellular response to very-low-density lipoprotein particle stimulus" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to VLDL particle stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1905890 ! regulation of cellular response to very-low-density lipoprotein particle stimulus
relationship: positively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus

[Term]
id: GO:1905890
name: regulation of cellular response to very-low-density lipoprotein particle stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957]
synonym: "regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus

[Term]
id: GO:1905891
name: obsolete regulation of cellular response to thapsigargin
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1905892
name: obsolete negative regulation of cellular response to thapsigargin
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
synonym: "down regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to thapsigargin" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to thapsigargin" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1905893
name: obsolete positive regulation of cellular response to thapsigargin
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
synonym: "activation of cellular response to thapsigargin" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to thapsigargin" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1905894
name: obsolete regulation of cellular response to tunicamycin
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1905895
name: obsolete negative regulation of cellular response to tunicamycin
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
synonym: "down regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to tunicamycin" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to tunicamycin" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1905896
name: obsolete positive regulation of cellular response to tunicamycin
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
comment: This term was obsoleted because it represents an experimental condition to cause endoplasmic reticulum stress.
synonym: "activation of cellular response to tunicamycin" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to tunicamycin" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0034976

[Term]
id: GO:1905897
name: regulation of response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
synonym: "regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "regulation of response to ER stress" EXACT [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0034976 ! response to endoplasmic reticulum stress

[Term]
id: GO:1905898
name: positive regulation of response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]
synonym: "activation of cellular response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "activation of ER stress response" NARROW [GOC:TermGenie]
synonym: "activation of response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "activation of response to ER stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "up regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "upregulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ER stress" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress
relationship: positively_regulates GO:0034976 ! response to endoplasmic reticulum stress

[Term]
id: GO:1905899
name: regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
is_a: GO:1901861 ! regulation of muscle tissue development
relationship: regulates GO:0048745 ! smooth muscle tissue development

[Term]
id: GO:1905900
name: negative regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie]
is_a: GO:1901862 ! negative regulation of muscle tissue development
is_a: GO:1905899 ! regulation of smooth muscle tissue development
relationship: negatively_regulates GO:0048745 ! smooth muscle tissue development

[Term]
id: GO:1905901
name: positive regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
is_a: GO:1901863 ! positive regulation of muscle tissue development
is_a: GO:1905899 ! regulation of smooth muscle tissue development
relationship: positively_regulates GO:0048745 ! smooth muscle tissue development

[Term]
id: GO:1905902
name: regulation of mesoderm formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0001707 ! mesoderm formation

[Term]
id: GO:1905903
name: negative regulation of mesoderm formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie]
is_a: GO:1905902 ! regulation of mesoderm formation
is_a: GO:2000381 ! negative regulation of mesoderm development
relationship: negatively_regulates GO:0001707 ! mesoderm formation

[Term]
id: GO:1905904
name: positive regulation of mesoderm formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie]
synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie]
is_a: GO:1905902 ! regulation of mesoderm formation
is_a: GO:2000382 ! positive regulation of mesoderm development
relationship: positively_regulates GO:0001707 ! mesoderm formation

[Term]
id: GO:1905905
name: nematode pharyngeal gland morphogenesis
namespace: biological_process
def: "The developmental process by which a nematode pharyngeal gland is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:21868609]
synonym: "glandulae pharyngeae morphogenesis" RELATED [GOC:TermGenie]
synonym: "pharynx gland morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:1905906
name: regulation of amyloid fibril formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]
comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
synonym: "regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "regulation of amyloid structure formation" RELATED [GOC:TermGenie]
is_a: GO:0051246 ! regulation of protein metabolic process
is_a: GO:1902903 ! regulation of supramolecular fiber organization
relationship: regulates GO:1990000 ! amyloid fibril formation

[Term]
id: GO:1905907
name: negative regulation of amyloid fibril formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]
comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
synonym: "down regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "downregulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "inhibition of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of amyloid fibril formation" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of amyloid structure formation" RELATED [GOC:TermGenie]
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
is_a: GO:1905906 ! regulation of amyloid fibril formation
relationship: negatively_regulates GO:1990000 ! amyloid fibril formation

[Term]
id: GO:1905908
name: positive regulation of amyloid fibril formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]
comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
synonym: "activation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "activation of amyloid fibril formation" NARROW [GOC:TermGenie]
synonym: "activation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "activation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "up regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of amyloid structure formation" RELATED [GOC:TermGenie]
synonym: "upregulation of amyloid fibril assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of amyloid fibril formation" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid structure assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of amyloid structure formation" RELATED [GOC:TermGenie]
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
is_a: GO:1905906 ! regulation of amyloid fibril formation
relationship: positively_regulates GO:1990000 ! amyloid fibril formation

[Term]
id: GO:1905909
name: regulation of dauer entry
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333]
synonym: "regulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
is_a: GO:0061065 ! regulation of dauer larval development
relationship: regulates GO:0043053 ! dauer entry

[Term]
id: GO:1905910
name: negative regulation of dauer entry
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333]
synonym: "down regulation of dauer entry" EXACT [GOC:TermGenie]
synonym: "down regulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
synonym: "down-regulation of dauer entry" EXACT [GOC:TermGenie]
synonym: "down-regulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
synonym: "downregulation of dauer entry" EXACT [GOC:TermGenie]
synonym: "downregulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
synonym: "inhibition of dauer entry" NARROW [GOC:TermGenie]
synonym: "inhibition of nematode entry into dormancy" NARROW [GOC:TermGenie]
synonym: "negative regulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
is_a: GO:0061067 ! negative regulation of dauer larval development
is_a: GO:1905909 ! regulation of dauer entry
relationship: negatively_regulates GO:0043053 ! dauer entry

[Term]
id: GO:1905911
name: positive regulation of dauer entry
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333]
synonym: "activation of dauer entry" NARROW [GOC:TermGenie]
synonym: "activation of nematode entry into dormancy" NARROW [GOC:TermGenie]
synonym: "positive regulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
synonym: "up regulation of dauer entry" EXACT [GOC:TermGenie]
synonym: "up regulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
synonym: "up-regulation of dauer entry" EXACT [GOC:TermGenie]
synonym: "up-regulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
synonym: "upregulation of dauer entry" EXACT [GOC:TermGenie]
synonym: "upregulation of nematode entry into dormancy" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905909 ! regulation of dauer entry
relationship: positively_regulates GO:0043053 ! dauer entry

[Term]
id: GO:1905912
name: regulation of calcium ion export across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]
synonym: "regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "regulation of calcium ion export from cell" EXACT []
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
relationship: regulates GO:1990034 ! calcium ion export across plasma membrane

[Term]
id: GO:1905913
name: negative regulation of calcium ion export across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]
synonym: "down regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ion export from cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion export from cell" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion export from cell" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion efflux from cell" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium ion export from cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of calcium ion export from cell" EXACT []
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane
relationship: negatively_regulates GO:1990034 ! calcium ion export across plasma membrane

[Term]
id: GO:1905914
name: positive regulation of calcium ion export across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]
synonym: "activation of calcium ion efflux from cell" NARROW [GOC:TermGenie]
synonym: "activation of calcium ion export from cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium ion export from cell" EXACT []
synonym: "up regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion export from cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion export from cell" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion export from cell" EXACT [GOC:TermGenie]
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane
relationship: positively_regulates GO:1990034 ! calcium ion export across plasma membrane

[Term]
id: GO:1905915
name: regulation of cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0090679 ! cell differentiation involved in phenotypic switching

[Term]
id: GO:1905916
name: negative regulation of cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "down regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "downregulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "inhibition of cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1900240 ! negative regulation of phenotypic switching
is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching
relationship: negatively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching

[Term]
id: GO:1905917
name: positive regulation of cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "activation of cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "up regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "upregulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching
relationship: positively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching

[Term]
id: GO:1905918
name: regulation of CoA-transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
subset: gocheck_obsoletion_candidate
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:1905919
name: negative regulation of CoA-transferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of CoA-transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CoA-transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CoA-transferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of CoA-transferase activity" NARROW [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1905918 ! regulation of CoA-transferase activity

[Term]
id: GO:1905920
name: positive regulation of CoA-transferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
subset: gocheck_obsoletion_candidate
synonym: "activation of CoA-transferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of CoA-transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CoA-transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CoA-transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1905918 ! regulation of CoA-transferase activity

[Term]
id: GO:1905921
name: regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
relationship: regulates GO:0008292 ! acetylcholine biosynthetic process

[Term]
id: GO:1905922
name: negative regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
relationship: negatively_regulates GO:0008292 ! acetylcholine biosynthetic process

[Term]
id: GO:1905923
name: positive regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
relationship: positively_regulates GO:0008292 ! acetylcholine biosynthetic process

[Term]
id: GO:1905924
name: obsolete regulation of invadopodium assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
synonym: "regulation of invadopodium formation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905925
name: obsolete negative regulation of invadopodium assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
synonym: "down regulation of invadopodium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of invadopodium formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of invadopodium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of invadopodium formation" EXACT [GOC:TermGenie]
synonym: "downregulation of invadopodium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of invadopodium formation" EXACT [GOC:TermGenie]
synonym: "inhibition of invadopodium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of invadopodium formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of invadopodium formation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905926
name: obsolete positive regulation of invadopodium assembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
synonym: "activation of invadopodium assembly" NARROW [GOC:TermGenie]
synonym: "activation of invadopodium formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of invadopodium formation" EXACT [GOC:TermGenie]
synonym: "up regulation of invadopodium assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of invadopodium formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of invadopodium assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of invadopodium formation" EXACT [GOC:TermGenie]
synonym: "upregulation of invadopodium assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of invadopodium formation" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905927
name: obsolete regulation of invadopodium disassembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
is_obsolete: true

[Term]
id: GO:1905928
name: obsolete negative regulation of invadopodium disassembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
synonym: "down regulation of invadopodium disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of invadopodium disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of invadopodium disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of invadopodium disassembly" NARROW [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905929
name: obsolete positive regulation of invadopodium disassembly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033]
comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO.
synonym: "activation of invadopodium disassembly" NARROW [GOC:TermGenie]
synonym: "up regulation of invadopodium disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of invadopodium disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of invadopodium disassembly" EXACT [GOC:TermGenie]
is_obsolete: true

[Term]
id: GO:1905930
name: regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching
relationship: regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching

[Term]
id: GO:1905931
name: negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down-regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "downregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "inhibition of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT []
synonym: "negative regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "negative regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905916 ! negative regulation of cell differentiation involved in phenotypic switching
is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
relationship: negatively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching

[Term]
id: GO:1905932
name: positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "activation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "activation of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up-regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905917 ! positive regulation of cell differentiation involved in phenotypic switching
is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
relationship: positively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching

[Term]
id: GO:1905933
name: regulation of cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0001709 ! cell fate determination

[Term]
id: GO:1905934
name: negative regulation of cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578]
synonym: "down regulation of cell fate determination" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell fate determination" EXACT [GOC:TermGenie]
synonym: "downregulation of cell fate determination" EXACT [GOC:TermGenie]
synonym: "inhibition of cell fate determination" NARROW [GOC:TermGenie]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:1905933 ! regulation of cell fate determination
relationship: negatively_regulates GO:0001709 ! cell fate determination

[Term]
id: GO:1905935
name: positive regulation of cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578]
synonym: "activation of cell fate determination" NARROW [GOC:TermGenie]
synonym: "up regulation of cell fate determination" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell fate determination" EXACT [GOC:TermGenie]
synonym: "upregulation of cell fate determination" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905933 ! regulation of cell fate determination
relationship: positively_regulates GO:0001709 ! cell fate determination

[Term]
id: GO:1905936
name: regulation of germ cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0036093 ! germ cell proliferation

[Term]
id: GO:1905937
name: negative regulation of germ cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905936 ! regulation of germ cell proliferation
relationship: negatively_regulates GO:0036093 ! germ cell proliferation

[Term]
id: GO:1905938
name: positive regulation of germ cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905936 ! regulation of germ cell proliferation
relationship: positively_regulates GO:0036093 ! germ cell proliferation

[Term]
id: GO:1905939
name: regulation of gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0008406 ! gonad development

[Term]
id: GO:1905940
name: negative regulation of gonad development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "down regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gonad development" EXACT [GOC:TermGenie]
synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gonad development" NARROW [GOC:TermGenie]
synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0008406 ! gonad development

[Term]
id: GO:1905941
name: positive regulation of gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "activation of gonad development" NARROW [GOC:TermGenie]
synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gonad development" EXACT [GOC:TermGenie]
synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0008406 ! gonad development

[Term]
id: GO:1905942
name: regulation of formation of growth cone in injured axon
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525]
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: regulates GO:0048689 ! formation of growth cone in injured axon

[Term]
id: GO:1905943
name: negative regulation of formation of growth cone in injured axon
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525]
synonym: "down regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of growth cone in injured axon" NARROW [GOC:TermGenie]
is_a: GO:0048688 ! negative regulation of sprouting of injured axon
is_a: GO:1905942 ! regulation of formation of growth cone in injured axon
relationship: negatively_regulates GO:0048689 ! formation of growth cone in injured axon

[Term]
id: GO:1905944
name: positive regulation of formation of growth cone in injured axon
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525]
synonym: "activation of formation of growth cone in injured axon" NARROW [GOC:TermGenie]
synonym: "up regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie]
is_a: GO:0048687 ! positive regulation of sprouting of injured axon
is_a: GO:1905942 ! regulation of formation of growth cone in injured axon
relationship: positively_regulates GO:0048689 ! formation of growth cone in injured axon

[Term]
id: GO:1905945
name: regulation of response to calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397]
synonym: "regulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0051592 ! response to calcium ion

[Term]
id: GO:1905946
name: negative regulation of response to calcium ion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397]
synonym: "down regulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "down regulation of response to calcium ion" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to calcium ion" EXACT [GOC:TermGenie]
synonym: "downregulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "downregulation of response to calcium ion" EXACT [GOC:TermGenie]
synonym: "inhibition of response to Ca2+ ion" NARROW [GOC:TermGenie]
synonym: "inhibition of response to calcium ion" NARROW [GOC:TermGenie]
synonym: "negative regulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1905945 ! regulation of response to calcium ion
relationship: negatively_regulates GO:0051592 ! response to calcium ion

[Term]
id: GO:1905947
name: positive regulation of response to calcium ion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397]
synonym: "activation of response to Ca2+ ion" NARROW [GOC:TermGenie]
synonym: "activation of response to calcium ion" NARROW [GOC:TermGenie]
synonym: "positive regulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "up regulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "up regulation of response to calcium ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to calcium ion" EXACT [GOC:TermGenie]
synonym: "upregulation of response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "upregulation of response to calcium ion" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1905945 ! regulation of response to calcium ion
relationship: positively_regulates GO:0051592 ! response to calcium ion

[Term]
id: GO:1905948
name: ABC-type 3',5'-cyclic GMP transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out)." [GO_REF:0000070, GOC:TermGenie, PMID:18310115]
synonym: "3',5'-cyclic GMP transmembrane-transporting ATPase activity" EXACT []
synonym: "ATP-dependent 3',5'-cyclic GMP transmembrane transporter activity" EXACT []
synonym: "ATPase-coupled 3',5'-cyclic GMP transmembrane transporter activity" RELATED []
synonym: "ATPase-coupled cGMP transmembrane transporter activity" EXACT []
xref: RHEA:66188
is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0140359 ! ABC-type transporter activity

[Term]
id: GO:1905949
name: negative regulation of calcium ion import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]
comment: An example of this is PPP3CA in human (Q08209) in PMID:17640527 (inferred from direct assay).
synonym: "down regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion import across plasma membrane" NARROW [GOC:TermGenie]
is_a: GO:0090281 ! negative regulation of calcium ion import
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane
relationship: negatively_regulates GO:0098703 ! calcium ion import across plasma membrane

[Term]
id: GO:1905951
name: mitochondrion DNA recombination
namespace: biological_process
def: "Any DNA recombination that takes place in mitochondrion." [GO_REF:0000062, GOC:TermGenie, PMID:8087883]
synonym: "DNA recombination in mitochondria" EXACT [GOC:TermGenie]
is_a: GO:0006310 ! DNA recombination
is_a: GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:1905952
name: regulation of lipid localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0010876 ! lipid localization

[Term]
id: GO:1905953
name: negative regulation of lipid localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1905952 ! regulation of lipid localization
relationship: negatively_regulates GO:0010876 ! lipid localization

[Term]
id: GO:1905954
name: positive regulation of lipid localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "activation of lipid localisation" NARROW [GOC:TermGenie]
synonym: "activation of lipid localization" NARROW [GOC:TermGenie]
synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1905952 ! regulation of lipid localization
relationship: positively_regulates GO:0010876 ! lipid localization

[Term]
id: GO:1905955
name: negative regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]
synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901509 ! regulation of endothelial tube morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
relationship: negatively_regulates GO:0061154 ! endothelial tube morphogenesis

[Term]
id: GO:1905956
name: positive regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]
synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901509 ! regulation of endothelial tube morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
relationship: positively_regulates GO:0061154 ! endothelial tube morphogenesis

[Term]
id: GO:1905957
name: regulation of cellular response to alcohol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:1901419 ! regulation of response to alcohol
relationship: regulates GO:0097306 ! cellular response to alcohol

[Term]
id: GO:1905958
name: negative regulation of cellular response to alcohol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "down regulation of cellular response to alcohol" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to alcohol" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to alcohol" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to alcohol" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1901420 ! negative regulation of response to alcohol
is_a: GO:1905957 ! regulation of cellular response to alcohol
relationship: negatively_regulates GO:0097306 ! cellular response to alcohol

[Term]
id: GO:1905959
name: positive regulation of cellular response to alcohol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "activation of cellular response to alcohol" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to alcohol" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to alcohol" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to alcohol" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1901421 ! positive regulation of response to alcohol
is_a: GO:1905957 ! regulation of cellular response to alcohol
relationship: positively_regulates GO:0097306 ! cellular response to alcohol

[Term]
id: GO:1905960
name: response to differentiation-inducing factor 2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:19684855, PMID:3355503]
synonym: "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one" EXACT []
synonym: "response to DIF-2" RELATED []
synonym: "response to DIF2" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:1905961
name: protein-cysteine S-palmitoyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of protein-cysteine S-palmitoyltransferase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20851885]
comment: An example of this is ERF2 in Saccharomyces cerevisiae (Q06551) in PMID:20851885 (inferred from direct assay)
synonym: "Palmitoyltransferase ERF2-SHR5 complex" NARROW []
synonym: "Palmitoyltransferase ERF2/SHR5 complex" NARROW []
is_a: GO:0002178 ! palmitoyltransferase complex

[Term]
id: GO:1905962
name: glutamatergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron." [GO_REF:0000086, GOC:TermGenie, PMID:24030726]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:1990000
name: amyloid fibril formation
namespace: biological_process
def: "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins." [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159]
comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
synonym: "amyloid fibril assembly" RELATED []
synonym: "amyloid structure assembly" RELATED []
synonym: "amyloid structure formation" RELATED []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0097435 ! supramolecular fiber organization

[Term]
id: GO:1990001
name: obsolete inhibition of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "OBSOLETE. Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
is_obsolete: true
replaced_by: GO:2000117

[Term]
id: GO:1990002
name: methylglyoxal reductase (NADPH) (acetol producing) activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH." [PMID:16077126, RHEA:27986]
synonym: "methylglyoxal reductase (NADPH-dependent, acetol producing)" EXACT []
xref: MetaCyc:RXN0-4281
xref: RHEA:27986
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:1990003
name: IDP phosphatase activity
namespace: molecular_function
alt_id: GO:0090450
def: "Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate." [PMID:20385596, PMID:22849572, RHEA:35207]
synonym: "IDP diphosphatase activity" BROAD []
synonym: "IDPase activity" EXACT []
synonym: "inosine diphosphatase activity" EXACT []
synonym: "inosine-diphosphatase activity" EXACT []
xref: EC:3.6.1.64
xref: Reactome:R-HSA-2509816 "NUDT16 hydrolyses IDP to IMP"
xref: RHEA:35207
is_a: GO:0017110 ! nucleoside diphosphate phosphatase activity

[Term]
id: GO:1990004
name: obsolete XDP phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: XDP + H2O = XMP + phosphate." [PMID:20385596]
comment: This term was obsoleted because there is no evidence that this reaction exist in vivo.
is_obsolete: true

[Term]
id: GO:1990005
name: granular vesicle
namespace: cellular_component
def: "A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells." [NIF_Subcellular:sao478230652]
xref: NIF_Subcellular:sao478230652
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:1990006
name: amorphous vesicle
namespace: cellular_component
def: "A cytoplasmic membrane-bounded vesicle first described in dendrites, categorized by smooth membranes, electron-lucent interiors and irregular shapes. Sometimes occurs in clumps. Amorphous vesicles have been found to contain material taken up from the extracellular space, therefore suggesting that they may be part of the endosomal pathway." [NIF_Subcellular:sao1531915298, PMID:11896161]
xref: NIF_Subcellular:sao1531915298
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:1990007
name: membrane stack
namespace: cellular_component
def: "A configuration of endoplasmic reticulum (ER) found in Purkinje cells in the cerebellum and in axons in the lateral vestibular nucleus, consisting of parallel and interconnecting tubules whose outer surfaces are covered by particles or ringlike structures." [ISBN:9780195065718, NIF_Subcellular:sao2114874506]
xref: NIF_Subcellular:sao2114874506
is_a: GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:1990008
name: neurosecretory vesicle
namespace: cellular_component
def: "A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus." [ISBN:0195065719, NIF_Subcellular:sao2031592629]
xref: NIF_Subcellular:sao2031592629
is_a: GO:1990005 ! granular vesicle

[Term]
id: GO:1990009
name: retinal cell apoptotic process
namespace: biological_process
alt_id: GO:0046674
def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675]
synonym: "induction of retinal programmed cell death" RELATED []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:1990010
name: compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768]
is_a: GO:1990009 ! retinal cell apoptotic process

[Term]
id: GO:1990011
name: laminated body
namespace: cellular_component
def: "Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus." [ISBN:0195065719, NIF_Subcellular:sao506721981]
synonym: "laminated inclusion body" EXACT []
xref: NIF_Subcellular:sao506721981
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:1990012
name: complex laminated body
namespace: cellular_component
def: "A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint." [NIF_Subcellular:nlx_151681]
synonym: "CLB" RELATED []
xref: NIF_Subcellular:nlx_151681
is_a: GO:1990011 ! laminated body

[Term]
id: GO:1990013
name: presynaptic grid
namespace: cellular_component
def: "A hexagonal array of electron dense particles attached to the cytoplasmic face of the presynaptic membrane." [ISBN:0716723808, NIF_Subcellular:sao1730664005]
synonym: "pre-synaptic grid" EXACT []
xref: NIF_Subcellular:sao1730664005
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:1990014
name: orthogonal array
namespace: cellular_component
def: "Square array of closely spaced intramembrane particles, 4-6 nm in size, that form supramolecular aggregates found in the plasma membrane of astrocytes, skeletal muscle and epithelial cells. They have been shown to contain aquaporins (water channels)." [NIF_Subcellular:sao1747012216, PMID:22718347]
synonym: "OAP" RELATED []
synonym: "orthogonal array of particles" EXACT []
synonym: "square array" RELATED []
xref: NIF_Subcellular:sao1747012216
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:1990015
name: ensheathing process
namespace: cellular_component
def: "A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma." [NIF_Subcellular:sao1376748732]
synonym: "ensheathing process of Schwann cell" NARROW []
xref: NIF_Subcellular:sao1376748732
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:1990016
name: neck portion of tanycyte
namespace: cellular_component
def: "Elongated portion of a tanycyte that sticks into the periventricular layer of neuropil where it appears to contact a blood vessel; characterized by numerous cytoplasmic extensions. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:0195065719, NIF_Subcellular:sao901230115]
synonym: "neck portion" BROAD []
xref: NIF_Subcellular:sao901230115
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:1990017
name: somatic portion of tanycyte
namespace: cellular_component
def: "Portion of a tanycyte that lies within the ependyma and contains the nucleus. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:0195065719, NIF_Subcellular:sao401910342]
synonym: "somatic portion" BROAD []
xref: NIF_Subcellular:sao401910342
is_a: GO:0044297 ! cell body

[Term]
id: GO:1990018
name: tail portion of tanycyte
namespace: cellular_component
def: "Elongated process of a tanycyte, devoid of cytoplasmic extensions, that courses through the hypothalamic nuclei to form small endfoot processes that terminate either on blood vessels or at the pial surface of the brain. A tanycyte is a specialized elongated ventricular ependymal cell." [ISBN:0195065719, NIF_Subcellular:sao1749953771]
synonym: "tail portion" BROAD []
xref: NIF_Subcellular:sao1749953771
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:1990019
name: protein storage vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole." [GOC:tb, PMID:21670741]
is_a: GO:0007033 ! vacuole organization

[Term]
id: GO:1990020
name: recurrent axon collateral
namespace: cellular_component
def: "Axon collateral that ramifies in the area of the soma of the cell of origin." [NIF_Subcellular:sao1642494436]
synonym: "recurrent collateral" BROAD []
xref: NIF_Subcellular:sao1642494436
is_a: GO:0044303 ! axon collateral

[Term]
id: GO:1990021
name: Schaffer axon collateral
namespace: cellular_component
def: "Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1." [NIF_Subcellular:nlx_subcell_20090511]
synonym: "Schaffer collateral" BROAD [NIF_Subcellular:sao1950673097]
xref: NIF_Subcellular:nlx_subcell_20090511
is_a: GO:0044303 ! axon collateral

[Term]
id: GO:1990022
name: obsolete RNA polymerase III complex import into nucleus
namespace: biological_process
def: "OBSOLETE. The directed movement of an RNA polymerase III complex from the cytoplasm to the nucleus." [GOC:mcc, PMID:23267056]
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
synonym: "DNA-directed RNA polymerase III complex import into nucleus" EXACT []
synonym: "DNA-directed RNA polymerase III complex localization to nucleus" EXACT []
synonym: "RNA polymerase III complex import into nucleus" EXACT []
synonym: "RNA polymerase III complex localisation to nucleus" EXACT []
synonym: "RNA polymerase III complex localization to nucleus" RELATED []
is_obsolete: true
consider: GO:0006606

[Term]
id: GO:1990023
name: mitotic spindle midzone
namespace: cellular_component
def: "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]
is_a: GO:0051233 ! spindle midzone
relationship: part_of GO:0072686 ! mitotic spindle

[Term]
id: GO:1990024
name: C bouton
namespace: cellular_component
def: "Synaptic bouton found in spinal cord on the soma and proximal dendrites of motor neurons." [NIF_Subcellular:nlx_subcell_100208]
xref: NIF_Subcellular:nlx_subcell_100208
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:1990025
name: F bouton
namespace: cellular_component
def: "Synaptic bouton found in the ventral horn of the spinal cord. F boutons range in diameter from 0.5 to 7 um and contain flattened or pleomorphic synaptic vesicles." [NIF_Subcellular:nlx_subcell_100206]
xref: NIF_Subcellular:nlx_subcell_100206
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:1990026
name: hippocampal mossy fiber expansion
namespace: cellular_component
def: "Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites." [NIF_Subcellular:nlx_subcell_1005002]
synonym: "dentate gyrus granule cell axonal bouton" RELATED []
synonym: "dentate gyrus mossy fiber expansion" RELATED []
synonym: "mossy fiber expansion" BROAD []
xref: NIF_Subcellular:nlx_subcell_1005002
is_a: GO:0043195 ! terminal bouton
relationship: part_of GO:0097457 ! hippocampal mossy fiber

[Term]
id: GO:1990027
name: S bouton
namespace: cellular_component
def: "Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles." [NIF_Subcellular:nlx_subcell_100207]
xref: NIF_Subcellular:nlx_subcell_100207
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:1990028
name: intermediate voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded." [GOC:BHF, GOC:rl, PMID:16382099, Wikipedia:Calcium_channel]
synonym: "R-type calcium channel" RELATED []
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:1990029
name: vasomotion
namespace: biological_process
def: "The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm." [GOC:sl, PMID:14993429, PMID:15678091, PMID:1932763]
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:1990030
name: pericellular basket
namespace: cellular_component
def: "Ramification of basket cell axon surrounding cell bodies, forming the characteristic pericellular baskets from which the cell class derives its name." [NIF_Subcellular:sao413722576]
synonym: "peri cellular basket" EXACT []
synonym: "peri-cellular basket" EXACT []
xref: NIF_Subcellular:sao413722576
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:1990031
name: pinceau fiber
namespace: cellular_component
def: "Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment." [NIF_Subcellular:sao109906988]
xref: NIF_Subcellular:sao109906988
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:1990032
name: parallel fiber
namespace: cellular_component
def: "A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium." [ISBN:0195159551, NIF_Subcellular:nlx_330]
xref: NIF_Subcellular:nlx_330
is_a: GO:0030424 ! axon

[Term]
id: GO:1990033
name: dendritic branch point
namespace: cellular_component
def: "The part of a dendritic tree where it branches, giving rise to a dendritic branch." [GOC:aruk, GOC:bc, NIF_Subcellular:sao1348591767]
synonym: "branch point of dendrite" EXACT []
xref: NIF_Subcellular:sao1348591767
is_a: GO:0061845 ! neuron projection branch point
relationship: part_of GO:0097447 ! dendritic tree

[Term]
id: GO:1990034
name: calcium ion export across plasma membrane
namespace: biological_process
def: "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:2145281]
synonym: "calcium ion efflux from cell" EXACT [GOC:vw, PMID:2145281]
synonym: "calcium ion export from cell" EXACT []
is_a: GO:0070588 ! calcium ion transmembrane transport
is_a: GO:0140115 ! export across plasma membrane

[Term]
id: GO:1990036
name: calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "The directed movement of calcium ions into a sarcoplasmic reticulum." [GOC:BHF, PMID:17286271]
is_a: GO:0046907 ! intracellular transport
is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport

[Term]
id: GO:1990037
name: Lewy body core
namespace: cellular_component
def: "The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments." [NIF_Subcellular:sao6587439252]
xref: NIF_Subcellular:sao6587439252
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097413 ! Lewy body

[Term]
id: GO:1990038
name: Lewy body corona
namespace: cellular_component
def: "The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array." [NIF_Subcellular:sao5764355747]
synonym: "halo" BROAD []
xref: NIF_Subcellular:sao5764355747
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0097413 ! Lewy body

[Term]
id: GO:1990039
name: hypolemmal cisterna
namespace: cellular_component
def: "Specialized part of the smooth endoplasmic reticulum that closely underlies the plasma membrane, usually within 60 nm or closer." [ISBN:0195065719, NIF_Subcellular:sao1634374950]
synonym: "hypolemmal cisternae" EXACT []
xref: NIF_Subcellular:sao1634374950
is_a: GO:0120082 ! smooth endoplasmic reticulum cisterna

[Term]
id: GO:1990040
name: sub-surface cisterna
namespace: cellular_component
def: "Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane." [ISBN:0195065719, NIF_Subcellular:sao128470897]
synonym: "sub-surface cisternae" EXACT []
xref: NIF_Subcellular:sao128470897
is_a: GO:1990039 ! hypolemmal cisterna

[Term]
id: GO:1990042
name: glycerol dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced." [PMID:22979944]
synonym: "glycerol dehydrogenase activity, NAD or NADP as acceptor" EXACT []
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:1990043
name: 5' deoxyribonuclease (pyrimidine dimer) activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.-, GOC:al, PMID:9708997]
is_a: GO:0033892 ! deoxyribonuclease (pyrimidine dimer) activity

[Term]
id: GO:1990044
name: protein localization to lipid droplet
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet." [GOC:sart, PMID:22505614]
synonym: "protein localisation to adiposome" EXACT []
synonym: "protein localisation to lipid body" EXACT []
synonym: "protein localisation to lipid droplet" EXACT []
synonym: "protein localisation to lipid particle" EXACT []
synonym: "protein localization to adiposome" EXACT []
synonym: "protein localization to lipid body" EXACT []
synonym: "protein localization to lipid particle" EXACT []
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:1990045
name: sclerotium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sclerotium over time, from its formation to the mature structure. A sclerotium is a mycelial resting body, resistant to adverse environmental conditions." [GOC:di, PMID:21148914]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:1990046
name: stress-induced mitochondrial fusion
namespace: biological_process
def: "Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis." [GOC:lb, PMID:19360003]
synonym: "mitochondrial fusion in response to stress" RELATED []
synonym: "SIMH" NARROW []
synonym: "stress-induced mitochondrial hyperfusion" NARROW []
is_a: GO:0008053 ! mitochondrial fusion
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:1990047
name: spindle matrix
namespace: cellular_component
def: "A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis." [GOC:ans, PMID:19273613, PMID:22855526]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:1990048
name: anterograde neuronal dense core vesicle transport
namespace: biological_process
def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451]
subset: goslim_synapse
synonym: "anterograde dense core granule trafficking" EXACT []
synonym: "anterograde dense core granule transport" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099519 ! dense core granule cytoskeletal transport

[Term]
id: GO:1990049
name: retrograde neuronal dense core vesicle transport
namespace: biological_process
def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653]
subset: goslim_synapse
synonym: "retrograde dense core granule trafficking" EXACT []
synonym: "retrograde dense core granule transport" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099519 ! dense core granule cytoskeletal transport

[Term]
id: GO:1990050
name: phosphatidic acid transfer activity
namespace: molecular_function
def: "Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]
synonym: "intermembrane PA transfer activity" EXACT []
synonym: "intermembrane phosphatidic acid transfer activity" NARROW []
synonym: "phosphatidic acid carrier activity" EXACT []
synonym: "phosphatidic acid transporter activity" BROAD []
is_a: GO:0120014 ! phospholipid transfer activity

[Term]
id: GO:1990051
name: activation of protein kinase C activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase C." [PMID:3156004]
subset: gocheck_obsoletion_candidate
synonym: "PKC activation" EXACT []
synonym: "protein kinase C activation" EXACT []
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:1990052
name: ER to chloroplast lipid transport
namespace: biological_process
def: "The directed movement of a lipid from the endoplasmic reticulum (ER) to the chloroplast." [PMID:18689504]
synonym: "endoplasmic reticulum to chloroplast lipid transport" EXACT []
synonym: "ER to chloroplast lipid trafficking" EXACT []
is_a: GO:0032365 ! intracellular lipid transport
is_a: GO:1901965 ! endoplasmic reticulum to chloroplast transport

[Term]
id: GO:1990053
name: DNA-5-methylcytosine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site." [PMID:23316050]
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:1990054
name: response to temozolomide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:1990055
name: phenylacetaldehyde synthase activity
namespace: molecular_function
def: "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2." [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519]
synonym: "aromatic aldehyde synthase" BROAD []
xref: EC:4.1.1.109
xref: MetaCyc:RXN-8990
xref: RHEA:55532
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:1990056
name: obsolete protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of an amino acid residue in a substrate protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP, thereby targeting the substrate to the proteasomal ubiquitin mediated protein catabolic process." [PMID:21098119, PMID:21993622, PMID:23264631]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process" EXACT []
is_obsolete: true

[Term]
id: GO:1990057
name: obsolete cell cycle arrest in response to DNA damage stimulus
namespace: biological_process
def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of DNA damage from environmental insults or errors during metabolism." [GOC:rph, PMID:10630641]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "cell cycle arrest in response to DNA damage stimulus" EXACT []
is_obsolete: true

[Term]
id: GO:1990058
name: fruit replum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit replum over time, from its formation to the mature structure. The fruit replum is a portion of fruit placenta tissue that divides a fruit into two or more chambers and develops from a replum." [PMID:23133401, PO:0025267]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:1990059
name: fruit valve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces." [PMID:23133401, PO:0000033]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:1990060
name: maltose transport complex
namespace: cellular_component
def: "Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK." [PMID:18033289]
synonym: "maltose ABC transporter complex" EXACT []
synonym: "maltose ATP-binding cassette transporter complex" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:1990061
name: bacterial degradosome
namespace: cellular_component
def: "The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase." [GOC:bhm, PMID:21805185]
is_a: GO:0000177 ! cytoplasmic exosome (RNase complex)
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990062
name: RPAP3/R2TP/prefoldin-like complex
namespace: cellular_component
def: "A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity." [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]
synonym: "R2TP/prefoldin-like complex" RELATED []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990063
name: Bam protein complex
namespace: cellular_component
def: "Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex." [GOC:bhm, PMID:20378773]
synonym: "OMP complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane

[Term]
id: GO:1990064
name: ground tissue pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterning of the ground tissue." [PMID:23444357]
synonym: "ground tissue patterning" EXACT []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:1990065
name: Dxr protein complex
namespace: cellular_component
def: "A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)." [GOC:bhm, PMID:15339150]
synonym: "1-deoxy-D-xylulose 5-phosphate reductoisomerase complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990066
name: energy quenching
namespace: biological_process
def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence." [PMID:10938857]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:1990067
name: intrachromosomal DNA recombination
namespace: biological_process
def: "The process of DNA recombination occurring within a single chromosome." [PMID:7748165]
synonym: "intrastrand DNA recombination" EXACT []
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:1990068
name: seed dehydration
namespace: biological_process
def: "The seed development process whose outcome is the drying of a maturing seed." [PMID:20138563]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0010431 ! seed maturation

[Term]
id: GO:1990069
name: stomatal opening
namespace: biological_process
def: "The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [PMID:21749899]
is_a: GO:0010118 ! stomatal movement

[Term]
id: GO:1990070
name: TRAPPI protein complex
namespace: cellular_component
def: "A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast." [GOC:bhm, PMID:20375281, PMID:22669257]
synonym: "TRAPP core complex" EXACT []
is_a: GO:0030008 ! TRAPP complex
relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment

[Term]
id: GO:1990071
name: TRAPPII protein complex
namespace: cellular_component
def: "A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]
is_a: GO:0030008 ! TRAPP complex
relationship: part_of GO:0005768 ! endosome
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:1990072
name: TRAPPIII protein complex
namespace: cellular_component
def: "A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257]
is_a: GO:0030008 ! TRAPP complex
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:1990073
name: perforation plate
namespace: cellular_component
def: "A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations)." [GOC:PO_curators, ISBN:0471245194]
comment: Part of a vessel member (PO:0002003). May be simple, with one perforation, or multiperforate, with more than one perforation. Perforation plates are usually on the end walls of a cell, but may also be on the side walls.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005618 ! cell wall

[Term]
id: GO:1990074
name: polyuridylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588]
is_a: GO:0006402 ! mRNA catabolic process
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process
is_a: GO:0061157 ! mRNA destabilization

[Term]
id: GO:1990075
name: periciliary membrane compartment
namespace: cellular_component
def: "A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis." [GOC:cilia, GOC:dr, GOC:krc, PMID:22342749]
synonym: "PCMC" EXACT []
is_a: GO:0098590 ! plasma membrane region

[Term]
id: GO:1990076
name: cell wall polysaccharide catabolic process involved in abscission
namespace: biological_process
def: "Any cell wall polysaccharide catabolic process that is involved in abscission." [GOC:TermGenie, PMID:23479623]
is_a: GO:0044347 ! cell wall polysaccharide catabolic process
relationship: part_of GO:0009838 ! abscission

[Term]
id: GO:1990077
name: primosome complex
namespace: cellular_component
def: "Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207]
synonym: "primosome" EXACT []
is_a: GO:0032993 ! protein-DNA complex
relationship: part_of GO:0030894 ! replisome

[Term]
id: GO:1990078
name: replication inhibiting complex
namespace: cellular_component
def: "A protein complex that inhibits multiple events of replication initiation during one replication cycle." [GOC:bhm, PMID:21708944]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030894 ! replisome

[Term]
id: GO:1990079
name: cartilage homeostasis
namespace: biological_process
alt_id: GO:1902094
alt_id: GO:1902095
alt_id: GO:1902096
def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function." [GOC:hjd, PMID:21652695]
synonym: "negative regulation of cartilage homeostasis" RELATED []
synonym: "positive regulation of cartilage homeostasis" RELATED []
synonym: "regulation of cartilage homeostasis" RELATED []
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:1990080
name: 2-phenylethylamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity." [PMID:16878137]
synonym: "beta-phenylethylamine receptor activity" EXACT []
is_a: GO:0008227 ! G protein-coupled amine receptor activity

[Term]
id: GO:1990081
name: trimethylamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine trimethylamine to initiate a change in cell activity." [PMID:16878137]
is_a: GO:0001594 ! trace-amine receptor activity

[Term]
id: GO:1990082
name: DnaA-L2 complex
namespace: cellular_component
def: "A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2." [GOC:bhm, PMID:21288885]
is_a: GO:1990078 ! replication inhibiting complex

[Term]
id: GO:1990083
name: DnaA-Hda complex
namespace: cellular_component
def: "A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda." [GOC:bhm, PMID:21708944]
is_a: GO:1990078 ! replication inhibiting complex

[Term]
id: GO:1990084
name: DnaA-Dps complex
namespace: cellular_component
def: "A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps." [GOC:bhm, PMID:18284581]
is_a: GO:1990078 ! replication inhibiting complex

[Term]
id: GO:1990085
name: Hda-beta clamp complex
namespace: cellular_component
def: "A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda." [GOC:bhm, PMID:15150238]
synonym: "Hda-DnaN complex" EXACT []
synonym: "Hda-dpo3b complex" EXACT []
is_a: GO:1990078 ! replication inhibiting complex

[Term]
id: GO:1990086
name: lens fiber cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [CL:0011004, GOC:hjd, PMID:11095619]
is_a: GO:1904019 ! epithelial cell apoptotic process

[Term]
id: GO:1990088
name: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase
namespace: molecular_function
alt_id: GO:0043851
def: "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+." [GOC:hjd, PMID:10077852, RHEA:45208]
comment: This function is the second step in the pathway of methanogenesis from methanol.
synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT []
synonym: "methanol-specific methylcobalamin:coenzyme M methyltransferase activity" EXACT []
synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT []
synonym: "methylcobamide:coenzyme M methyltransferase activity" BROAD []
synonym: "methylcobamide:CoM methyltransferase activity" BROAD []
xref: EC:2.1.1.246
xref: MetaCyc:RXN-8096
xref: RHEA:45208
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:1990089
name: response to nerve growth factor
namespace: biological_process
def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805]
synonym: "response to nerve growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:1990090
name: cellular response to nerve growth factor stimulus
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805, Wikipedia:Nerve_growth_factor]
synonym: "cellular response to NGF" EXACT [GOC:bf, Wikipedia:Nerve_growth_factor]
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:1990089 ! response to nerve growth factor

[Term]
id: GO:1990091
name: sodium-dependent self proteolysis
namespace: biological_process
def: "The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380]
is_a: GO:0097264 ! self proteolysis

[Term]
id: GO:1990092
name: calcium-dependent self proteolysis
namespace: biological_process
def: "The calcium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380]
is_a: GO:0097264 ! self proteolysis

[Term]
id: GO:1990093
name: obsolete negative regulation of N-methyl-D-aspartate receptor clustering
namespace: biological_process
def: "OBSOLETE. The negative regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "negative regulation of N-methyl-D-aspartate receptor clustering" EXACT []
synonym: "negative regulation of NMDA receptor clustering" EXACT []
is_obsolete: true

[Term]
id: GO:1990094
name: obsolete positive regulation of N-methyl-D-aspartate receptor clustering
namespace: biological_process
def: "OBSOLETE. The positive regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "positive regulation of N-methyl-D-aspartate receptor clustering" EXACT []
synonym: "positive regulation of NMDA receptor clustering" EXACT []
is_obsolete: true

[Term]
id: GO:1990095
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:kmv, PMID:16166371]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0034599
consider: GO:0045944

[Term]
id: GO:1990096
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to superoxide
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:kmv, PMID:12869585, PMID:16166371]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0034599
consider: GO:0045944

[Term]
id: GO:1990097
name: SeqA-DNA complex
namespace: cellular_component
def: "A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle." [GOC:bhm, PMID:12379844, PMID:15933720, PMID:23149570]
synonym: "SeqA-dsDNA complex" NARROW []
synonym: "SeqA-hemimethylated DNA complex" NARROW []
synonym: "SeqA-hemimethylation dsDNA complex" NARROW []
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:1990098
name: core primosome complex
namespace: cellular_component
def: "A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication." [GOC:bhm, PMID:21856207]
comment: The core primosome refers to a helicase-primase complex, and should not be confused with the more general GO term 'primosome complex ; GO:1990077'.
synonym: "core primosome" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex

[Term]
id: GO:1990099
name: pre-primosome complex
namespace: cellular_component
def: "Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component." [GOC:bhm, PMID:18179598, PMID:20129058, PMID:8663105]
synonym: "pre-priming complex" EXACT [GOC:bhm]
synonym: "pre-primosome" EXACT [GOC:bhm, PMID:11994158]
synonym: "pre-replication complex" RELATED [GOC:bhm]
synonym: "preprimosome" EXACT [GOC:bhm, PMID:2824502]
synonym: "preprimosome complex" EXACT [GOC:bhm]
synonym: "prereplication complex" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex

[Term]
id: GO:1990100
name: DnaB-DnaC complex
namespace: cellular_component
def: "A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC)." [GOC:bhm, PMID:20129058]
comment: DnaB and DnaC may be present in different ratios in different forms of the DnaB-DnaC complex, including a DnaB6-DnaC3 complex active at the oriC, and a DnaB6-DnaC6 complex.
synonym: "DnaB6-DnaC3 complex" NARROW [PMID:20129058]
synonym: "DnaB6-DnaC6 complex" NARROW [PMID:20129058]
synonym: "helicase-loading complex" BROAD [GOC:bhm]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:1990077 ! primosome complex

[Term]
id: GO:1990101
name: DnaA-oriC complex
namespace: cellular_component
def: "A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle." [GOC:bhm, PMID:19833870]
synonym: "DnaA-DNA complex" BROAD [GOC:bhm]
is_a: GO:1990077 ! primosome complex

[Term]
id: GO:1990102
name: DnaA-DiaA complex
namespace: cellular_component
def: "A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA." [GOC:bhm, PMID:15326179, PMID:17699754]
synonym: "DnaA-DiaA-DNA complex" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex

[Term]
id: GO:1990103
name: DnaA-HU complex
namespace: cellular_component
def: "A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC." [GOC:bhm, PMID:18179598]
synonym: "DnaA-HU-DNA complex" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex

[Term]
id: GO:1990104
name: DNA bending complex
namespace: cellular_component
def: "A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction." [GOC:bhm, PMID:17097674]
synonym: "histone-like DNA binding complex" NARROW [GOC:bhm]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990105
name: obsolete regulation of voltage-gated potassium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity." [PMID:19219384]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of voltage-gated potassium channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990107
name: thiazole synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O." [PMID:22031445, RHEA:26297]
comment: Part of the pathway for thiamine biosynthesis.
synonym: "1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity" EXACT []
xref: EC:2.8.1.10
xref: RHEA:26297
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:1990108
name: protein linear deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein." [PMID:23708998]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:1990109
name: rejection of pollen from other species
namespace: biological_process
def: "The recognition and rejection of pollen of one species by cells in the stigma of another species." [PMID:21205670]
synonym: "unilateral interspecific incompatibility" EXACT []
is_a: GO:0048544 ! recognition of pollen
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:1990110
name: callus formation
namespace: biological_process
def: "The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate." [ISBN:0070187517]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:1990111
name: spermatoproteasome complex
namespace: cellular_component
def: "A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity." [GOC:sp, PMID:23706739]
is_a: GO:0000502 ! proteasome complex

[Term]
id: GO:1990112
name: RQC complex
namespace: cellular_component
def: "A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins." [GOC:rb, PMID:23178123, PMID:23232563]
synonym: "ribosome quality control complex" EXACT [PMID:23178123, PMID:23232563]
synonym: "ribosome-bound quality control complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990113
name: RNA polymerase I assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex." [GOC:rb, PMID:23459708]
synonym: "DNA-directed RNA polymerase I complex assembly" EXACT []
synonym: "RNA Polymerase I complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1990114
name: RNA polymerase II core complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex." [GOC:rb, PMID:23459708]
synonym: "DNA-directed RNA polymerase II, core complex assembly" EXACT []
synonym: "RNA Polymerase II assembly" BROAD []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1990115
name: RNA polymerase III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex." [GOC:rb, PMID:23459708]
synonym: "DNA-directed RNA polymerase III complex assembly" EXACT []
synonym: "RNA Polymerase III complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1990116
name: ribosome-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411]
synonym: "RAD" BROAD []
synonym: "ribosome-associated degradation" BROAD []
synonym: "ribosome-associated ubiquitin-dependent protein breakdown" EXACT []
synonym: "ribosome-associated ubiquitin-dependent protein catabolism" EXACT []
synonym: "ribosome-associated ubiquitin-dependent protein degradation" EXACT []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:1990117
name: B cell receptor apoptotic signaling pathway
namespace: biological_process
def: "An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:15214043]
synonym: "B cell receptor extrinsic apoptotic signaling pathway" EXACT []
synonym: "extrinsic apoptotic signaling pathway via B cell antigen receptor" RELATED []
synonym: "extrinsic apoptotic signaling pathway via BCR" RELATED []
is_a: GO:0050853 ! B cell receptor signaling pathway
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway
relationship: part_of GO:0001783 ! B cell apoptotic process

[Term]
id: GO:1990119
name: RNA helicase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of an RNA helicase." [GOC:rb, PMID:23721653]
synonym: "ATP-dependent RNA helicase inhibitor activity" EXACT []
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0042030 ! ATPase inhibitor activity

[Term]
id: GO:1990120
name: obsolete messenger ribonucleoprotein complex assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex." [GOC:rb, PMID:23721653]
comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
is_obsolete: true

[Term]
id: GO:1990121
name: H-NS complex
namespace: cellular_component
def: "A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA." [GOC:bhm, PMID:12592399]
synonym: "DNA-binding protein H-NS complex" EXACT []
synonym: "histone-like protein H-NS complex" EXACT []
is_a: GO:1990104 ! DNA bending complex
relationship: part_of GO:0005829 ! cytosol
relationship: part_of GO:0043590 ! bacterial nucleoid

[Term]
id: GO:1990124
name: obsolete messenger ribonucleoprotein complex
namespace: cellular_component
def: "OBSOLETE. A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules." [GOC:bf, PMID:15574591, PMID:21915786]
comment: This term was obsoleted becasue it does not represent a specific complex
synonym: "messenger ribonucleoprotein particle" RELATED [PMID:21915786]
synonym: "mRNA-protein complex" EXACT [PMID:21915786]
synonym: "mRNP" EXACT [PMID:21915786]
synonym: "mRNP complex" EXACT [PMID:15574591, PMID:21915786]
is_obsolete: true

[Term]
id: GO:1990125
name: DiaA complex
namespace: cellular_component
def: "A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation." [GOC:bhm, PMID:17699754]
synonym: "DiaA homotetramer" EXACT [GOC:bf, PMID:17699754]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990127
name: intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered." [GOC:krc, GOC:mtg_apoptosis, PMID:16571598]
is_a: GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator

[Term]
id: GO:1990128
name: obsolete pre-primosome complex involved in replication initiation
namespace: cellular_component
def: "OBSOLETE. A protein-DNA complex involved in replication initiation at the origin of replication." [GOC:bhm, PMID:21856207]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "pre-primosome complex involved in replication initiation" EXACT []
is_obsolete: true

[Term]
id: GO:1990129
name: obsolete pre-primosome complex involved in replication restart
namespace: cellular_component
def: "OBSOLETE. A protein-DNA complex involved in replication restart after a stalled replication fork has been repaired." [GOC:bhm, PMID:17139333]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "pre-primosome complex involved in replication restart" EXACT []
is_obsolete: true

[Term]
id: GO:1990130
name: GATOR1 complex
namespace: cellular_component
def: "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]
comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
synonym: "IML1 complex" EXACT []
synonym: "SEACIT complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0035859 ! Seh1-associated complex

[Term]
id: GO:1990131
name: Gtr1-Gtr2 GTPase complex
namespace: cellular_component
def: "A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins." [GOC:rb, PMID:10388807, PMID:16143306]
is_a: GO:1905360 ! GTPase complex

[Term]
id: GO:1990132
name: obsolete release of misfolded protein from chaperone
namespace: biological_process
def: "OBSOLETE. The release of misfolded proteins that are being held by the chaperone heat shock protein (Hsp) and targeting them for destruction by the Ub-proteasome machinery." [GOC:rb, PMID:23530227]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "release of misfolded protein from chaperone" EXACT []
is_obsolete: true

[Term]
id: GO:1990133
name: molybdopterin adenylyltransferase complex
namespace: cellular_component
def: "A heterotetrameric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; in human the subunits are MOCS3 and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, PMID:11713534, PMID:16669776, PMID:18491921]
synonym: "molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex" EXACT []
synonym: "MPT adenylyltransferase complex" EXACT []
is_a: GO:1902503 ! adenylyltransferase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990134
name: epithelial cell apoptotic process involved in palatal shelf morphogenesis
namespace: biological_process
def: "An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf." [GOC:dph, GOC:mtg_apoptosis, PMID:16607638]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
is_a: GO:1904019 ! epithelial cell apoptotic process
relationship: part_of GO:0062009 ! secondary palate development

[Term]
id: GO:1990135
name: flavonoid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative." [PMID:23611783]
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:1990136
name: linoleate 9S-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate." [GOC:rph, RHEA:30291]
synonym: "9-lipoxygenase activity" RELATED []
synonym: "9S-lipoxygenase activity" RELATED []
synonym: "linoleate 9-lipoxygenase activity" RELATED []
synonym: "linoleate:oxygen 9S-oxidoreductase activity" EXACT []
xref: EC:1.13.11.58
xref: RHEA:30291
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:1990137
name: plant seed peroxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: RH + ROOH = ROH + ROH." [EC:1.11.2.3, PMID:19467604]
synonym: "peroxygenase activity" BROAD [PMID:19467604]
synonym: "plant seed peroxidase activity" RELATED []
xref: EC:1.11.2.3
xref: MetaCyc:RXN-11819
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor

[Term]
id: GO:1990138
name: neuron projection extension
namespace: biological_process
def: "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "neurite extension" NARROW []
synonym: "neuron process extension" EXACT []
synonym: "neuron protrusion extension" EXACT []
synonym: "neuronal cell projection extension" EXACT []
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048812 ! neuron projection morphogenesis

[Term]
id: GO:1990139
name: protein localization to nuclear periphery
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the nuclear periphery." [GOC:mah, PMID:23703609]
is_a: GO:0034504 ! protein localization to nucleus

[Term]
id: GO:1990140
name: molybdopterin synthase complex
namespace: cellular_component
def: "A heterotetrameric protein complex that catalyses sulfur transfer from the sulfur carrier subunit of molybdopterin synthase to precursor Z to synthesize molybdopterin as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, PMID:11135669, PMID:16669776]
subset: goslim_metagenomics
synonym: "molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex" RELATED []
synonym: "molybdopterin converting factor complex" EXACT []
synonym: "MPT synthase complex" EXACT []
is_a: GO:1990228 ! sulfurtransferase complex

[Term]
id: GO:1990143
name: CoA-synthesizing protein complex
namespace: cellular_component
def: "A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway." [GOC:rb, PMID:23789928]
synonym: "CoA-SPC" EXACT []
synonym: "coenzyme A-synthesizing protein complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1990144
name: intrinsic apoptotic signaling pathway in response to hypoxia
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456]
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway
relationship: part_of GO:0071456 ! cellular response to hypoxia

[Term]
id: GO:1990145
name: maintenance of translational fidelity
namespace: biological_process
def: "Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template." [GOC:hjd, ISBN:9781936113460, PMID:21841312]
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:1990146
name: protein localization to rhabdomere
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a rhabdomere." [GOC:sart, PMID:8335687]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1990147
name: talin binding
namespace: molecular_function
def: "Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types." [GOC:hjd, PMID:23372168]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:1990148
name: glutamate dehydrogenase complex
namespace: cellular_component
def: "A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies." [GOC:bhm, PMID:22393408, PMID:23412807]
synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex" RELATED []
synonym: "glutamate dehydrogenase (NADP+) complex" RELATED []
synonym: "glutamic acid dehydrogenase complex" RELATED []
synonym: "glutamic dehydrogenase complex" RELATED []
synonym: "L-glutamate dehydrogenase complex" RELATED []
synonym: "L-glutamate:NADP+ oxidoreductase (deaminating) complex" RELATED []
synonym: "L-glutamic acid dehydrogenase complex" RELATED []
synonym: "NAD(P)-glutamate dehydrogenase complex" RELATED []
synonym: "NAD(P)H-dependent glutamate dehydrogenase complex" RELATED []
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:1990149
name: obsolete COPI vesicle coating
namespace: biological_process
def: "OBSOLETE. The addition of COPI proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:rb, PMID:11970962]
comment: This term was obsoleted at the TermGenie Gatekeeper stage because COPI vesicles are formed on Golgi membranes, and the existing term 'COPI coating of Golgi vesicle ; GO:0048205' describes this process.
synonym: "COPI vesicle coating" EXACT []
is_obsolete: true

[Term]
id: GO:1990150
name: VEGF-A complex
namespace: cellular_component
def: "A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase." [GOC:bf, GOC:bhm, PMID:12207021, PMID:19658168]
synonym: "vascular endothelial growth factor A complex" EXACT [GOC:bhm]
is_a: GO:0036454 ! growth factor complex

[Term]
id: GO:1990151
name: protein localization to cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at the cell tip." [PMID:22768263]
synonym: "protein localisation to cell tip" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1990153
name: maintenance of protein localization to heterochromatin
namespace: biological_process
def: "A process in which a protein is maintained in a location in telomeric heterochromatin." [PMID:21300781]
synonym: "maintenance of protein localisation to heterochromatin" EXACT [GOC:mah]
synonym: "maintenance of protein location in heterochromatin" RELATED [GOC:mah]
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0097355 ! protein localization to heterochromatin

[Term]
id: GO:1990154
name: enzyme IIA-maltose transporter complex
namespace: cellular_component
def: "A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter." [GOC:bf, GOC:bhm, PMID:23770568]
synonym: "EIIA(Glc)-MalFGK2 complex" EXACT [PMID:23770568]
synonym: "EIIA(Glc)-maltose transporter complex" EXACT [PMID:23770568]
synonym: "maltose transporter inhibitor complex" RELATED [GOC:bhm]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:1990155
name: Dsc E3 ubiquitin ligase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane." [GOC:mah, PMID:23760507]
synonym: "Dsc complex assembly" EXACT [PMID:23760507]
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:1990156
name: DnaB-DnaG complex
namespace: cellular_component
def: "A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes." [GOC:bhm, PMID:14557266]
synonym: "DnaB-DnaG primosome complex" RELATED [GOC:bhm]
is_a: GO:0033202 ! DNA helicase complex
relationship: part_of GO:1990098 ! core primosome complex

[Term]
id: GO:1990157
name: DnaA-DnaB-DnaC complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation." [GOC:bhm, PMID:20129058]
is_a: GO:1990099 ! pre-primosome complex

[Term]
id: GO:1990158
name: DnaB-DnaC-DnaT-PriA-PriB complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105]
synonym: "DnaB-DnaC-DnaT-PriA-PriB preprimosome" EXACT [PMID:8663105]
synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105]
is_a: GO:1990099 ! pre-primosome complex

[Term]
id: GO:1990159
name: DnaB-DnaC-DnaT-PriA-PriC complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105]
synonym: "DnaB-DnaC-DnaT-PriA-PriC preprimosome" EXACT [PMID:8663105]
synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105]
is_a: GO:1990099 ! pre-primosome complex

[Term]
id: GO:1990160
name: DnaB-DnaC-Rep-PriC complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:19941825, PMID:8663105]
synonym: "DnaB-DnaC-Rep-PriC preprimosome" EXACT [PMID:8663105]
synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105]
is_a: GO:1990099 ! pre-primosome complex

[Term]
id: GO:1990161
name: DnaB helicase complex
namespace: cellular_component
def: "A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair." [GOC:bhm, PMID:17947583]
synonym: "DnaB hexamer" EXACT [GOC:bhm]
is_a: GO:0033202 ! DNA helicase complex

[Term]
id: GO:1990162
name: histone H3K4 deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein." [GOC:al, PMID:23771057, PMID:28450737]
synonym: "histone deacetylase activity (H3-K4 specific)" BROAD []
synonym: "histone H3-K4 deacetylase activity" EXACT []
synonym: "histone H3K14 deacetylase activity" BROAD []
is_a: GO:0141050 ! histone H3K deacetylase activity
is_a: GO:0141221 ! histone deacetylase activity, hydrolytic mechanism

[Term]
id: GO:1990164
name: obsolete histone H2A phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of a phosphate group." [GOC:mah, PMID:23080121]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0035173

[Term]
id: GO:1990165
name: single-strand break-containing DNA binding
namespace: molecular_function
def: "Binding to damaged DNA containing single-strand breaks (SSBs)." [GOC:al, PMID:21984210]
synonym: "single-strand break-containing damaged DNA binding" EXACT []
synonym: "SSB-containing DNA binding" EXACT []
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:1990166
name: protein localization to site of double-strand break
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred." [GOC:mah, PMID:23080121]
synonym: "protein localisation to site of double-strand break" EXACT [GOC:mah]
synonym: "protein localization to double-strand break site" EXACT [GOC:mah]
synonym: "protein localization to site of DSB" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:1990167
name: protein K27-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein." [PMID:23827681]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:1990168
name: protein K33-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein." [PMID:23827681]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:1990169
name: stress response to copper ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus." [GOC:kmv, PMID:23437011]
synonym: "response to copper ion stress" EXACT []
synonym: "response to copper toxicity" RELATED []
synonym: "stress response to copper" BROAD []
is_a: GO:0046688 ! response to copper ion
is_a: GO:0097501 ! stress response to metal ion

[Term]
id: GO:1990170
name: stress response to cadmium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus." [GOC:kmv]
synonym: "response to cadmium ion stress" EXACT []
synonym: "response to cadmium toxicity" RELATED []
synonym: "stress response to cadmium" BROAD []
is_a: GO:0046686 ! response to cadmium ion
is_a: GO:0097501 ! stress response to metal ion

[Term]
id: GO:1990171
name: SCF complex disassembly in response to cadmium stress
namespace: biological_process
def: "The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress." [GOC:rb, PMID:23000173]
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: part_of GO:0071276 ! cellular response to cadmium ion

[Term]
id: GO:1990172
name: G protein-coupled receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor." [PMID:12142540, PMID:23954414]
synonym: "G-protein coupled receptor catabolic process" EXACT []
is_a: GO:0032801 ! receptor catabolic process
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway

[Term]
id: GO:1990173
name: protein localization to nucleoplasm
namespace: biological_process
alt_id: GO:0032066
def: "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952]
synonym: "nucleolus to nucleoplasm transport" RELATED []
synonym: "protein localisation to nucleoplasm" EXACT [GOC:mah]
is_a: GO:0034504 ! protein localization to nucleus

[Term]
id: GO:1990174
name: phosphodiesterase decapping endonuclease activity
namespace: molecular_function
def: "Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA." [GOC:dgf, PMID:20802481]
synonym: "G(5')pppN pyrophosphatase activity" RELATED []
is_a: GO:0016891 ! RNA endonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:1990175
name: EH domain binding
namespace: molecular_function
def: "Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R." [GOC:hjd, PMID:11911876, PMID:21115825]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990176
name: MalFGK2 complex
namespace: cellular_component
def: "Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG." [GOC:bhm, PMID:19250913]
comment: The MalFGK2 complex lacks the maltose-binding subunit present in GO:1990060.
synonym: "MalF-MalG-MalK(2) complex" EXACT [GOC:bf]
synonym: "MalF-MalG-MalK-MalK complex" EXACT [GOC:bf]
synonym: "MalFGK(2) complex" EXACT [PMID:19250913]
synonym: "maltose transport complex, core subunit" EXACT [GOC:bhm]
synonym: "maltose transport MalFGK2 complex" EXACT [GOC:bhm]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:1990060 ! maltose transport complex

[Term]
id: GO:1990177
name: IHF-DNA complex
namespace: cellular_component
def: "A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid." [GOC:bhm, PMID:17097674]
synonym: "IHF complex" EXACT [GOC:bhm]
synonym: "IHFa-IHFb-DNA complex" EXACT [GOC:bhm]
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:1990104 ! DNA bending complex
relationship: part_of GO:0043590 ! bacterial nucleoid

[Term]
id: GO:1990178
name: HU-DNA complex
namespace: cellular_component
def: "A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure." [GOC:bhm, PMID:17360520]
synonym: "HU complex" BROAD [GOC:bhm]
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:1990104 ! DNA bending complex
relationship: part_of GO:0043590 ! bacterial nucleoid

[Term]
id: GO:1990179
name: protein localization to actomyosin contractile ring
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the actomyosin contractile ring." [GOC:mah, PMID:23349808]
synonym: "protein localisation to actomyosin contractile ring" EXACT []
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:0072741 ! protein localization to cell division site
is_a: GO:1903119 ! protein localization to actin cytoskeleton

[Term]
id: GO:1990180
name: mitochondrial tRNA 3'-end processing
namespace: biological_process
def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:mah, GOC:TermGenie, PMID:23928301]
synonym: "tRNA 3' processing in mitochondria" EXACT [GOC:TermGenie]
synonym: "tRNA 3' processing in mitochondrion" EXACT [GOC:TermGenie]
synonym: "tRNA 3'-end processing in mitochondria" EXACT [GOC:TermGenie]
is_a: GO:0000965 ! mitochondrial RNA 3'-end processing
is_a: GO:0042780 ! tRNA 3'-end processing
is_a: GO:0090646 ! mitochondrial tRNA processing

[Term]
id: GO:1990181
name: acetyl-CoA biosynthetic process from pantothenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA." [GOC:mah, PMID:23091701]
synonym: "acetyl-CoA anabolism from pantothenate" EXACT []
synonym: "acetyl-CoA formation from pantothenate" RELATED []
synonym: "acetyl-CoA synthesis from pantothenate" RELATED []
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0015939 ! pantothenate metabolic process

[Term]
id: GO:1990182
name: exosomal secretion
namespace: biological_process
def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898]
synonym: "exosomal protein secretion" NARROW [PMID:18617898]
synonym: "exosomal secretory pathway" EXACT [PMID:18617898]
synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd]
synonym: "multi-vesicular body fusion with plasma membrane" EXACT []
synonym: "secretion of exosome" EXACT [PMID:18617898]
is_a: GO:0006887 ! exocytosis
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0097734 ! extracellular exosome biogenesis

[Term]
id: GO:1990183
name: lymphatic vascular process in circulatory system
namespace: biological_process
def: "A circulatory process that occurs at the level of the lymphatic vasculature." [PMID:21576390]
is_a: GO:0003018 ! vascular process in circulatory system

[Term]
id: GO:1990184
name: amino acid transport complex
namespace: cellular_component
def: "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane." [GOC:kmv, PMID:14668347]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:1990185
name: regulation of lymphatic vascular permeability
namespace: biological_process
def: "Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid." [PMID:23897233]
is_a: GO:0043114 ! regulation of vascular permeability
is_a: GO:1990183 ! lymphatic vascular process in circulatory system

[Term]
id: GO:1990186
name: regulation of lymphatic vessel size
namespace: biological_process
def: "Any process that modulates the size of lymphatic vessels." [PMID:23897233]
synonym: "regulation of collecting lymphatic vessel size" NARROW []
is_a: GO:0090066 ! regulation of anatomical structure size
is_a: GO:1990183 ! lymphatic vascular process in circulatory system

[Term]
id: GO:1990187
name: obsolete protein localization to mRNA
namespace: biological_process
def: "OBSOLETE. A process in which a protein is transported to, or maintained at mRNA." [GOC:rb, PMID:22890846]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "protein localization to mRNA" EXACT []
is_obsolete: true

[Term]
id: GO:1990188
name: euchromatin binding
namespace: molecular_function
def: "Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512]
is_a: GO:0003682 ! chromatin binding

[Term]
id: GO:1990189
name: peptide-serine-alpha-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]." [PMID:23912279, RHEA:50504]
xref: RHEA:50504
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity

[Term]
id: GO:1990190
name: peptide-glutamate-alpha-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide." [GOC:al, PMID:23912279]
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity

[Term]
id: GO:1990191
name: cobalamin transport complex
namespace: cellular_component
def: "Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD." [GOC:bhm, PMID:22569249]
synonym: "BtuCDF complex" EXACT []
synonym: "cobalamin-transporting BtuCDF complex" EXACT []
synonym: "vitamin B12 transport complex" EXACT []
synonym: "vitamin B12-transporting BtuCDF complex" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:1990192
name: collecting lymphatic vessel constriction
namespace: biological_process
def: "A decrease in the diameter of collecting lymphatic vessels." [PMID:23322290]
synonym: "lymphatic vessel myogenic constriction" EXACT []
is_a: GO:1990186 ! regulation of lymphatic vessel size

[Term]
id: GO:1990193
name: BtuCD complex
namespace: cellular_component
def: "Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer." [GOC:bhm, PMID:22569249]
synonym: "BtuC-BtuD complex" EXACT []
synonym: "cobalamin transport complex, core subunit" EXACT []
synonym: "vitamin B12 transport complex, core subunit" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:1990194
name: cytoplasmic U snRNP body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body." [PMID:19464282]
synonym: "U body assembly" RELATED []
is_a: GO:0022618 ! protein-RNA complex assembly

[Term]
id: GO:1990195
name: macrolide transmembrane transporter complex
namespace: cellular_component
def: "A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]
synonym: "AcrAB-TolC complex" NARROW []
synonym: "MacAB-TolC complex" NARROW []
synonym: "macrolide transporter" RELATED []
synonym: "macrolide transporter complex" BROAD []
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1990196
name: MacAB-TolC complex
namespace: cellular_component
def: "The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]
synonym: "macrolide transporter MacAB-TolC complex" EXACT []
is_a: GO:1990195 ! macrolide transmembrane transporter complex

[Term]
id: GO:1990197
name: methionine-importing ABC transporter complex
namespace: cellular_component
def: "An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner." [GOC:bhm, PMID:22095702]
synonym: "ATP-binding cassette (ABC) methionine importer complex" EXACT []
synonym: "ATP-dependent methionine importer complex" EXACT []
synonym: "ATP-dependent methionine importing complex" EXACT []
synonym: "ATP-dependent methionine-importing complex" EXACT []
synonym: "methionine transport complex" BROAD []
synonym: "methionine transporter" RELATED []
synonym: "methionine transporter complex" BROAD []
synonym: "methionine transporter complex, ATP-dependent" BROAD []
synonym: "MetNI complex" NARROW []
synonym: "MetNI transport complex" NARROW []
synonym: "MetNI transporter" RELATED []
synonym: "MetNI transporter complex" NARROW []
synonym: "MetNIQ complex" NARROW []
synonym: "MetNIQ transport complex" NARROW []
synonym: "MetNIQ transporter" RELATED []
synonym: "MetNIQ transporter complex" RELATED []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
is_a: GO:1902509 ! methionine-importing complex

[Term]
id: GO:1990198
name: ModE complex
namespace: cellular_component
def: "A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism." [GOC:bhm, PMID:12581638]
synonym: "ModE dimer" EXACT [GOC:bhm]
is_a: GO:0005667 ! transcription regulator complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990199
name: MsbA transporter complex
namespace: cellular_component
def: "An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD)." [GOC:bhm, PMID:18024585]
synonym: "MsbA complex" EXACT [GOC:bhm]
synonym: "MsbA dimer" EXACT [GOC:bhm]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:1990200
name: SsuD-SsuE complex
namespace: cellular_component
def: "A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation." [GOC:bhm, PMID:16997955]
synonym: "two-component alkanesulfonate monooxygenase system" RELATED [GOC:bhm]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990201
name: alkanesulfonate monooxygenase complex
namespace: cellular_component
def: "A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer." [GOC:bhm, PMID:10480865, PMID:16997955]
synonym: "SsuD complex" NARROW [GOC:bhm]
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990202
name: FMN reductase complex
namespace: cellular_component
def: "A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer." [GOC:bhm, PMID:10480865, PMID:16997955]
synonym: "flavin oxidoreductase complex, NAD(P)H-dependent" BROAD [GOC:bhm]
synonym: "FMN oxidoreductase complex, NAD(P)H-dependent" RELATED [GOC:bhm]
synonym: "FMN reductase complex, NAD(P)H-dependent" EXACT [GOC:bhm]
synonym: "SsuE complex" NARROW [GOC:bhm]
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990203
name: MdtBC Complex
namespace: cellular_component
def: "A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane." [GOC:bhm, PMID:20038594]
synonym: "multidrug efflux pump MdtBC" EXACT [GOC:bhm]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1990204
name: oxidoreductase complex
namespace: cellular_component
def: "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]
subset: goslim_metagenomics
synonym: "oxidation-reduction complex" EXACT []
synonym: "redox complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1990205
name: taurine dioxygenase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD." [GOC:bhm, PMID:12741810]
synonym: "2-aminoethanesulfonate dioxygenase complex" EXACT []
synonym: "alpha-ketoglutarate-dependent taurine dioxygenase complex" EXACT []
synonym: "TauD complex" NARROW []
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990206
name: jasmonyl-Ile conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine." [PMID:23943861]
synonym: "JA-Ile hydrolase" RELATED []
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:1990207
name: EmrE multidrug transporter complex
namespace: cellular_component
def: "A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer." [GOC:bhm, PMID:18024586]
synonym: "EmrE complex" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1990208
name: obsolete positive regulation by symbiont of RNA levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12182338, PMID:18703740]
comment: This term was obsoleted because it represents a readout.
is_obsolete: true
consider: GO:0052167

[Term]
id: GO:1990209
name: obsolete negative regulation by symbiont of RNA levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18703740]
comment: This term was obsoleted because it represents a readout.
is_obsolete: true
consider: GO:0052167

[Term]
id: GO:1990210
name: obsolete positive regulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "positive regulation by symbiont of auxin levels in host" EXACT []
synonym: "positive regulation by symbiont of IAA levels in host" EXACT []
is_obsolete: true

[Term]
id: GO:1990211
name: obsolete positive regulation by symbiont of jasmonic acid levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:14617079, PMID:16553894]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1990212
name: obsolete positive regulation by symbiont of ethylene levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:16167902]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1990213
name: obsolete negative regulation by symbiont of salicylic acid levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:17722699, PMID:20565685]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1990214
name: obsolete negative regulation by symbiont of host protein levels
namespace: biological_process
def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16840699, PMID:22233353]
comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
is_obsolete: true

[Term]
id: GO:1990215
name: symbiont-mediated perturbation of host vesicle-mediated transport
namespace: biological_process
def: "A process in which a symbiont alters or subverts vesicle-mediated transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22319451, PMID:24248335, PMID:30893609, PMID:31492901]
synonym: "negative regulation by symbiont of host intracellular transport" BROAD []
synonym: "symbiont-mediated perturbation of host endosomal trafficking" RELATED []
is_a: GO:0044068 ! symbiont-mediated perturbation of host cellular process

[Term]
id: GO:1990216
name: symbiont-mediated activation of host transcription
namespace: biological_process
def: "A process in which a symbiont initiates, promotes, or enhances transcription of genes into mRNA in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21994350]
synonym: "positive regulation by symbiont of host transcription" EXACT []
is_a: GO:0052026 ! symbiont-mediated perturbation of host transcription

[Term]
id: GO:1990217
name: symbiont-mediated suppression of host phytoalexin production
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts the production of phytoalexins in the host organism. Phytoalexins are produced by plants to fight against pathogens. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21402357]
synonym: "negative regulation by symbiont of host phytoalexin production" EXACT []
synonym: "suppression by symbiont of host phytoalexin production" EXACT []
is_a: GO:0052165 ! symbiont-mediated perturbation of host phytoalexin production

[Term]
id: GO:1990218
name: obsolete positive regulation by symbiont of abscisic acid levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17304219]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1990219
name: obsolete positive regulation by symbiont of host protein levels
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20615948]
comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
is_obsolete: true

[Term]
id: GO:1990220
name: GroEL-GroES complex
namespace: cellular_component
def: "Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins." [GOC:bhm, PMID:15313620]
synonym: "bacterial chaperonin ATPase complex" RELATED []
synonym: "bacterial chaperonin complex" RELATED []
is_a: GO:0016465 ! chaperonin ATPase complex

[Term]
id: GO:1990221
name: L-cysteine desulfurase complex
namespace: cellular_component
def: "A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes." [GOC:bhm, PMID:11827487]
synonym: "IscS" NARROW [GOC:bhm, GOC:dph]
synonym: "NifS" NARROW [GOC:bhm, GOC:dph]
synonym: "SufS complex" NARROW []
is_a: GO:1990228 ! sulfurtransferase complex

[Term]
id: GO:1990222
name: ProVWX complex
namespace: cellular_component
def: "The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions." [GOC:bhm, PMID:23249124]
synonym: "ATP-binding cassette (ABC) transporter complex ProVWX" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:1990223
name: obsolete positive regulation by symbiont of cytokinin levels in host
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24124900]
comment: This term was obsoleted because there is no evidence that this process exists.
is_obsolete: true

[Term]
id: GO:1990224
name: NMN phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate." [GOC:rb, PMID:21349851, RHEA:30815]
synonym: "beta-nicotinamide D-ribonucleotide phosphatase activity" EXACT []
synonym: "nicotinamide mononucleotide phosphatase activity" EXACT []
xref: RHEA:30815
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:1990225
name: rhoptry neck
namespace: cellular_component
def: "Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion." [GOC:giardia, GOC:pr, PMID:23499754, PMID:23937520, PMID:24002067, PMID:24070999]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0020008 ! rhoptry

[Term]
id: GO:1990226
name: histone methyltransferase binding
namespace: molecular_function
def: "Binding to a histone methyltransferase enzyme." [GOC:ame, GOC:BHF, PMID:19486527]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:1990227
name: paranodal junction maintenance
namespace: biological_process
def: "The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [GOC:pr, PMID:24011083]
synonym: "axoglial septate junction maintenance" EXACT []
synonym: "paranodal axoglial junction maintenance" EXACT []
synonym: "paranodal septate maintenance" EXACT []
is_a: GO:0045217 ! cell-cell junction maintenance

[Term]
id: GO:1990228
name: sulfurtransferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:17350958]
synonym: "SufE complex" NARROW [GOC:bhm]
synonym: "SufE dimer" NARROW [GOC:bhm]
synonym: "sulfur transfer complex" EXACT [GOC:bhm]
synonym: "ThiF-ThiS complex" RELATED [GOC:bhm]
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990229
name: iron-sulfur cluster assembly complex
namespace: cellular_component
def: "A protein complex capable of assembling an iron-sulfur (Fe-S) cluster." [GOC:bhm, PMID:17350958]
synonym: "Fe-S cluster assembly complex" NARROW [GOC:bhm]
synonym: "SufBCD complex" NARROW [GOC:bhm]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990230
name: iron-sulfur cluster transfer complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor), which may be a target protein or another Fe-S assembly complex. In humans, it consists of HSPA9, HSCB, GLRX5, ABCB7 and GFER." [GOC:bhm, PMID:19810706, PMID:34660592]
synonym: "Fe-S cluster transfer complex" EXACT [GOC:bhm]
synonym: "IscA complex" NARROW [GOC:bhm]
synonym: "SufA complex" NARROW [GOC:bhm]
synonym: "SufA dimer" NARROW [GOC:bhm]
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:1990231
name: STING complex
namespace: cellular_component
def: "A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response." [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378]
synonym: "stimulator of interferon genes complex" EXACT [GOC:bhm, PMID:22705373, PMID:23910378]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030659 ! cytoplasmic vesicle membrane

[Term]
id: GO:1990232
name: phosphomannomutase complex
namespace: cellular_component
def: "A protein complex capable of phosphomannomutase activity." [GOC:bhm, PMID:16540464]
synonym: "PMM-1 complex" NARROW [GOC:bhm]
synonym: "PMM-1 dimer" NARROW [GOC:bhm]
synonym: "PMM-2 complex" NARROW [GOC:bhm]
synonym: "PMM-2 dimer" NARROW [GOC:bhm]
is_a: GO:1990233 ! intramolecular phosphotransferase complex

[Term]
id: GO:1990233
name: intramolecular phosphotransferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule." [GOC:bhm, PMID:16540464]
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990234
name: transferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1990235
name: diamine N-acetyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of diamine N-acetyltransferase activity." [GOC:bhm, PMID:8077207]
synonym: "SAT complex" NARROW [GOC:bhm]
synonym: "SAT tetramer" NARROW [GOC:bhm]
synonym: "spermidine acetyltransferase complex" NARROW [GOC:bhm]
is_a: GO:1902493 ! acetyltransferase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990236
name: proteasome core complex import into nucleus
namespace: biological_process
def: "The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus." [GOC:dos, GOC:rb, PMID:23982732]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0051170 ! import into nucleus

[Term]
id: GO:1990238
name: double-stranded DNA endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks." [PMID:22885404]
synonym: "double-stranded DNA endodeoxyribonuclease activity" EXACT []
synonym: "dsDNA-specific endodeoxyribonuclease activity" RELATED []
is_a: GO:0004520 ! DNA endonuclease activity

[Term]
id: GO:1990239
name: steroid hormone binding
namespace: molecular_function
def: "Binding to a steroid hormone." [GOC:ln]
is_a: GO:0005496 ! steroid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:1990241
name: obsolete nucleotide binding complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that interacts selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. An example of this is STING in E. coli (Q86WV6)." [GOC:bhm, PMID:23910378]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "nucleotide binding complex" EXACT []
is_obsolete: true

[Term]
id: GO:1990242
name: obsolete innate immune response complex
namespace: cellular_component
def: "OBSOLETE. A protein complex involved in the innate immune response." [GOC:bhm, PMID:23910378]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "innate immune response complex" EXACT []
is_obsolete: true

[Term]
id: GO:1990243
name: atf1-pcr1 complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE)." [PMID:24224056]
is_a: GO:0035976 ! transcription factor AP-1 complex

[Term]
id: GO:1990244
name: histone H2AT120 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A." [PMID:24140421]
synonym: "histone H2A-T120 kinase activity" EXACT []
synonym: "histone kinase activity (H2A-T120 specific)" EXACT []
synonym: "histone threonine kinase activity (H2A-T120 specific)" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0140995 ! histone H2A kinase activity

[Term]
id: GO:1990245
name: obsolete histone H2A-T120 phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone." [PMID:24140421]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H2A phosphorylation at T120" EXACT []
synonym: "histone H2AT120 phosphorylation" EXACT []
is_obsolete: true
consider: GO:1990244

[Term]
id: GO:1990246
name: uniplex complex
namespace: cellular_component
def: "A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]
synonym: "mitochondrial uniporter complex" EXACT []
synonym: "mitochondrial uniporter holocomplex" EXACT []
is_a: GO:0034704 ! calcium channel complex
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:1990247
name: N6-methyladenosine-containing RNA reader activity
namespace: molecular_function
def: "A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]
synonym: "N6-methyladenosine-containing RNA binding" RELATED []
is_a: GO:0140517 ! protein-RNA adaptor activity

[Term]
id: GO:1990248
name: obsolete regulation of transcription from RNA polymerase II promoter in response to DNA damage
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0006974

[Term]
id: GO:1990249
name: nucleotide-excision repair, DNA damage recognition complex
namespace: cellular_component
def: "A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990250
name: transcription-coupled nucleotide-excision repair, DNA damage recognition complex
namespace: cellular_component
def: "A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906]
is_a: GO:1990249 ! nucleotide-excision repair, DNA damage recognition complex

[Term]
id: GO:1990251
name: nuclear exosome focus
namespace: cellular_component
def: "An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome." [GOC:al, GOC:vw, PMID:16823445, PMID:23980030, PMID:32012158]
synonym: "Mmi1 nuclear focus" EXACT []
synonym: "nuclear body" RELATED []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:1990252
name: Syp1 complex
namespace: cellular_component
def: "A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis." [GOC:bhm, PMID:19713939]
synonym: "Syp1 dimer" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle

[Term]
id: GO:1990253
name: cellular response to leucine starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine." [PMID:19033384]
is_a: GO:0034198 ! cellular response to amino acid starvation

[Term]
id: GO:1990254
name: keratin filament binding
namespace: molecular_function
def: "Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells." [GOC:krc, PMID:6170061]
is_a: GO:0019215 ! intermediate filament binding

[Term]
id: GO:1990255
name: subsynaptic reticulum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:21041451]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:1990256
name: signal clustering
namespace: biological_process
def: "Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response." [GOC:als, PMID:12011072, PMID:15603739]
synonym: "ligand clustering" BROAD [GOC:als]
is_a: GO:0009966 ! regulation of signal transduction

[Term]
id: GO:1990257
name: piccolo-bassoon transport vesicle
namespace: cellular_component
def: "A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270]
synonym: "PTV" RELATED []
is_a: GO:0030133 ! transport vesicle

[Term]
id: GO:1990258
name: obsolete histone glutamine methylation
namespace: biological_process
def: "OBSOLETE. The modification of a histone by addition of a methyl group to an glutamine residue." [PMID:24352239]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990259
name: histone H2AQ104 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to Q105 in yeast." [PMID:24352239]
synonym: "histone glutamine methylase activity" EXACT []
synonym: "histone glutamine methyltransferase activity" EXACT []
synonym: "histone glutamine N-methyltransferase activity" BROAD []
synonym: "histone-glutamine methyltransferase activity" EXACT []
synonym: "histone-glutamine N-methyltransferase activity" EXACT []
is_a: GO:0036009 ! protein-glutamine N-methyltransferase activity
is_a: GO:0140940 ! histone H2A methyltransferase activity

[Term]
id: GO:1990260
name: obsolete negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling." [PMID:24006488]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0000122
consider: GO:0006974

[Term]
id: GO:1990261
name: pre-mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA)." [GOC:rb, PMID:22844259]
synonym: "pre-mRNA decay" EXACT []
synonym: "unspliced RNA decay" EXACT []
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:1990262
name: anti-Mullerian hormone receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Upon ligand binding, the receptor  forms a complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators." [GOC:hjd, PMID:23624077]
comment: An example of this is Amhr2 in M. musculus (Q8K592) a receptor for anti-mullerian hormone, described in PMID:23624077.
synonym: "anti-Mullerian hormone signaling pathway" EXACT []
is_a: GO:0007178 ! cell surface receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:1990263
name: obsolete spore wall assembly MAPK cascade
namespace: biological_process
def: "OBSOLETE. A MAPK cascade that occurs as a result of deprivation of nourishment." [GOC:al, PMID:7501024]
comment: This term was obsoleted because this pathway is poorly defined.
synonym: "MAPK cascade in response to starvation" EXACT []
synonym: "MAPK cascade involved in nutrient response signaling" EXACT [GOC:al]
is_obsolete: true

[Term]
id: GO:1990264
name: peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
namespace: biological_process
def: "Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]
subset: gocheck_obsoletion_candidate
is_a: GO:0035335 ! peptidyl-tyrosine dephosphorylation
relationship: part_of GO:0006469 ! negative regulation of protein kinase activity

[Term]
id: GO:1990265
name: platelet-derived growth factor complex
namespace: cellular_component
def: "A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD)." [GOC:bhm, PMID:11331882]
comment: An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay).
synonym: "PDGF complex" RELATED []
synonym: "PDGF-AA dimer" NARROW []
synonym: "PDGF-AB dimer" NARROW []
synonym: "PDGF-BB dimer" NARROW []
synonym: "PDGF-CC dimer" NARROW []
synonym: "PDGF-DD dimer" NARROW []
is_a: GO:0036454 ! growth factor complex

[Term]
id: GO:1990266
name: neutrophil migration
namespace: biological_process
def: "The movement of a neutrophil within or between different tissues and organs of the body." [PMID:1826836]
is_a: GO:0097530 ! granulocyte migration

[Term]
id: GO:1990267
name: response to transition metal nanoparticle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle." [PMID:23150627]
synonym: "response to colloidal metal" RELATED []
synonym: "response to neutral metal atoms" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1990268
name: response to gold nanoparticle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus." [PMID:23150627]
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:1990269
name: RNA polymerase II C-terminal domain phosphoserine binding
namespace: molecular_function
def: "Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]
synonym: "RNA Pol II C-terminal domain phosphoserine binding" EXACT [GOC:di]
synonym: "RNAP II C-terminal domain phosphoserine binding" EXACT []
is_a: GO:0050815 ! phosphoserine residue binding
is_a: GO:0099122 ! RNA polymerase II C-terminal domain binding

[Term]
id: GO:1990270
name: platelet-derived growth factor receptor-ligand complex
namespace: cellular_component
def: "A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes." [GOC:bhm, PMID:11331882]
comment: An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).
synonym: "PDGF complex" BROAD []
synonym: "PDGF receptor-ligand complex" EXACT []
synonym: "PDGF-AA-receptor alpha complex" NARROW []
synonym: "PDGF-AB-receptor alpha complex" NARROW []
synonym: "PDGF-AB-receptor beta complex" NARROW []
synonym: "PDGF-BB-receptor alpha complex" NARROW []
synonym: "PDGF-BB-receptor alpha-beta complex" NARROW []
synonym: "PDGF-BB-receptor beta complex" NARROW []
synonym: "PDGF-CC-receptor alpha complex" NARROW []
synonym: "PDGF-CC-receptor alpha-beta complex" NARROW []
synonym: "PDGF-CC-receptor beta complex" NARROW []
synonym: "PDGF-DD-receptor alpha-beta complex" NARROW []
synonym: "PDGF-DD-receptor beta complex" NARROW []
synonym: "receptor-ligand complex" BROAD []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:1990271
name: obsolete anti-Mullerian hormone
namespace: molecular_function
def: "OBSOLETE. Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077]
comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077.
synonym: "anti-Mullerian hormone" EXACT []
is_obsolete: true

[Term]
id: GO:1990272
name: anti-Mullerian hormone receptor activity
namespace: molecular_function
def: "Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077]
comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077.
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:1990273
name: snRNA 2,2,7-trimethylguanosine (TMG) capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5' end of an snRNA. The snRNA capping process includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed U6 snRNA is also TMG capped." [GOC:vw, PMID:15590684]
synonym: "snRNA 2,2,7-trimethylguanosine (TMG) cap formation" EXACT []
synonym: "snRNA 5'-end processing" BROAD []
synonym: "snRNA capping" EXACT []
is_a: GO:0016180 ! snRNA processing
is_a: GO:0036260 ! RNA capping

[Term]
id: GO:1990274
name: obsolete mitotic actomyosin contractile ring disassembly
namespace: biological_process
def: "OBSOLETE. Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle." [PMID:14602073, PMID:22891673]
comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
is_obsolete: true
replaced_by: GO:1902404

[Term]
id: GO:1990275
name: preribosome binding
namespace: molecular_function
def: "Binding to a preribosome." [GOC:di, PMID:22735702]
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:1990276
name: RNA 5'-gamma-phosphate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule." [GOC:al, GOC:vw, PMID:22740346]
synonym: "RNA 5'-methyltransferase activity" RELATED []
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:1990277
name: parasexual reproduction with cellular fusion
namespace: biological_process
def: "A type of reproduction in which new individuals are produced from two individuals, with the fusion of two somatic cells." [GOC:di, PMID:26210747]
synonym: "mating" BROAD []
synonym: "parasexual conjugation with cellular fusion" EXACT []
xref: Wikipedia:Parasexual_cycle
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:1990278
name: obsolete positive regulation of MBF transcription factor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of the transcription factor MBF." [PMID:11795845]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "positive regulation of MBF transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990279
name: obsolete negative regulation of MBF transcription factor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor MBF." [PMID:24006488]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "negative regulation of MBF transcription factor activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990280
name: RNA localization to chromatin
namespace: biological_process
def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262]
synonym: "RNA localisation to chromatin" EXACT []
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:1990281
name: efflux pump complex
namespace: cellular_component
def: "A protein complex that is capable of efflux transmembrane transporter activity." [GOC:dos, PMID:21556065, PMID:9417051]
synonym: "efflux pump" EXACT []
synonym: "efflux transmembrane transporter complex" EXACT []
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1990294
name: obsolete peptidyl-threonine trans-autophosphorylation
namespace: biological_process
def: "OBSOLETE. The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [PMID:19357077]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990295
name: post-anaphase microtubule array
namespace: cellular_component
def: "A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center." [PMID:11792817, PMID:17072892, PMID:9601091]
comment: The best-characterized example is found in the fission yeast Schizosaccharomyces pombe. The eMTOC is cortical, but the post-anaphase array microtubules are not exclusively cortical.
synonym: "PAA" EXACT []
synonym: "post-anaphase array" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:1990297
name: renal amino acid absorption
namespace: biological_process
def: "A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:hjd, PMID:1526373]
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:1990298
name: bub1-bub3 complex
namespace: cellular_component
def: "Protein complex that associates with the kinetochores." [PMID:22521786]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990299
name: Bub1-Bub3 complex localization to kinetochore
namespace: biological_process
def: "A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore." [PMID:22521786]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0034501 ! protein localization to kinetochore

[Term]
id: GO:1990300
name: cellulosome binding
namespace: molecular_function
alt_id: GO:1990301
def: "Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides." [GOC:mengo_curators, PMID:11893054, PMID:15197390]
synonym: "scaffoldin complex binding" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:1990302
name: Bre1-Rad6 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis." [GOC:bhm, PMID:19531475]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
synonym: "Bre1-Rad6 complex" EXACT []
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:1990303
name: UBR1-RAD6 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes." [GOC:bhm, PMID:19531475]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
synonym: "UBR1-RAD6 complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:1990304
name: MUB1-RAD6-UBR2 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme." [GOC:bhm, PMID:18070918]
comment: This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:1990305
name: RAD6-UBR2 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation." [GOC:bhm, PMID:15504724]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:15504724
synonym: "RAD6-UBR2 complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:1990306
name: RSP5-BUL ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation." [GOC:bhm, PMID:9931424]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424
synonym: "RSP5-BUL1 complex" EXACT []
synonym: "RSP5-BUL2 complex" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:1990308
name: type-I dockerin domain binding
namespace: molecular_function
def: "Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990309
name: type-II dockerin domain binding
namespace: molecular_function
def: "Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990310
name: type-III dockerin domain binding
namespace: molecular_function
def: "Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990311
name: type-I cohesin domain binding
namespace: molecular_function
def: "Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990312
name: type-II cohesin domain binding
namespace: molecular_function
def: "Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990313
name: type-III cohesin domain binding
namespace: molecular_function
def: "Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990314
name: cellular response to insulin-like growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:20042609]
synonym: "cellular response to insulin-like growth factor" EXACT []
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:1990315
name: Mcs4 RR-MAPKKK complex
namespace: cellular_component
def: "A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress." [PMID:24255738]
comment: In S. pombe it consists of Mpr1, Tdh1, Mcs4, Win1, Wis4 and Wis1.
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990316
name: Atg1/ULK1 kinase complex
namespace: cellular_component
alt_id: GO:0034273
alt_id: GO:0070969
def: "A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]
synonym: "ATG1 kinase complex" EXACT []
synonym: "ATG1-ATG13 complex" EXACT []
synonym: "ATG1/ULK1 signaling complex" EXACT []
synonym: "Atg1p signalling complex" EXACT []
synonym: "autophagy-initiation complex" EXACT [GOC:autophagy, GOC:pad, GOC:PARL, PMID:26754330]
synonym: "ULK complex" EXACT [PMID:28816597]
synonym: "ULK1 complex" EXACT [PMID:26921696]
synonym: "ULK1 signaling complex" EXACT []
synonym: "ULK1-ATG13-FIP200 complex" EXACT []
synonym: "ULK1-ATG13-RB1CC1 complex" EXACT []
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:1990317
name: Gin4 complex
namespace: cellular_component
def: "A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved." [GOC:bhm, PMID:12058072]
synonym: "Gin4-septin complex" EXACT []
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0000144 ! cellular bud neck septin ring

[Term]
id: GO:1990318
name: collagen type XIX trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells." [GOC:bhm, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer
is_a: GO:0098651 ! basement membrane collagen trimer

[Term]
id: GO:1990319
name: collagen type XX trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XX) chains." [GOC:bhm, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer

[Term]
id: GO:1990320
name: collagen type XXI trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle." [GOC:bhm, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer

[Term]
id: GO:1990321
name: collagen type XXII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts." [GOC:bhm, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer

[Term]
id: GO:1990322
name: collagen type XXIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane." [GOC:bhm, PMID:17876790]
is_a: GO:0030936 ! transmembrane collagen trimer

[Term]
id: GO:1990323
name: collagen type XXIV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development." [GOC:bhm, PMID:17876790]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:1990324
name: collagen type XXVI trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXVI) chains." [GOC:bhm, PMID:17876790]
is_a: GO:0005581 ! collagen trimer
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:1990325
name: collagen type XXVII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone." [GOC:bhm, PMID:17876790, PMID:21421911]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:1990326
name: collagen type XXVIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXVIII) chains." [GOC:bhm, PMID:17876790]
is_a: GO:0005581 ! collagen trimer
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:1990327
name: collagen type XXV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane." [GOC:bhm, PMID:17876790]
is_a: GO:0030936 ! transmembrane collagen trimer

[Term]
id: GO:1990328
name: RPB4-RPB7 complex
namespace: cellular_component
def: "A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways." [GOC:bhm, PMID:15591044]
synonym: "RNA polymerase II, RPB4-RPB7 subcomplex" NARROW []
is_a: GO:0140535 ! intracellular protein-containing complex

[Term]
id: GO:1990329
name: IscS-TusA complex
namespace: cellular_component
def: "A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups." [GOC:bhm, PMID:20404999]
is_a: GO:1990221 ! L-cysteine desulfurase complex

[Term]
id: GO:1990330
name: IscS-IscU complex
namespace: cellular_component
def: "A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consists of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group." [GOC:bhm, PMID:20404999]
is_a: GO:1990221 ! L-cysteine desulfurase complex
is_a: GO:1990229 ! iron-sulfur cluster assembly complex

[Term]
id: GO:1990331
name: Hpa2 acetyltransferase complex
namespace: cellular_component
def: "A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules." [GOC:bhm, PMID:10600387]
is_a: GO:0070775 ! H3 histone acetyltransferase complex
is_a: GO:1902562 ! H4 histone acetyltransferase complex

[Term]
id: GO:1990332
name: Ire1 complex
namespace: cellular_component
def: "A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript." [GOC:bf, GOC:bhm, PMID:18191223, PMID:25437541]
comment: An example of this is Ire1 in S. cerevisiae (P32361) in PMID:18191223 (inferred from direct assay).
synonym: "ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1" EXACT [PMID:33140520]
synonym: "ERN1 complex" RELATED [HGNC:3449]
synonym: "Ire1 complex dimer" EXACT []
synonym: "Ire1 complex homodimer" EXACT []
synonym: "Ire1 complex homooligomer" EXACT []
synonym: "IRE1 dimer" EXACT [PMID:25437541]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
is_a: GO:1902554 ! serine/threonine protein kinase complex
is_a: GO:1902555 ! endoribonuclease complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:1990333
name: mitotic checkpoint complex, CDC20-MAD2 subcomplex
namespace: cellular_component
def: "A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20." [GOC:bhm, PMID:15879521]
comment: An example of this is cdc20 in Saccharomyces cerevisiae (P26309) in PMID:15879521 (inferred from direct assay).
synonym: "CDC20-MAD2 complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0033597 ! mitotic checkpoint complex

[Term]
id: GO:1990334
name: Bfa1-Bub2 complex
namespace: cellular_component
def: "A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation." [GOC:bhm, PMID:16449187]
is_a: GO:1902773 ! GTPase activator complex
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:1990338
name: laminin-14 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains." [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709]
synonym: "laminin-423" EXACT [GOC:dph, GOC:sl, PMID:15979864]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:1990339
name: laminin-522 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains." [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709]
synonym: "laminin-522" EXACT []
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:1990340
name: laminin-15 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains." [GOC:bhm, PMID:17453709]
synonym: "laminin-523" EXACT []
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:1990341
name: thrombospondin complex
namespace: cellular_component
def: "A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour." [GOC:bhm, PMID:18193164]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:1990342
name: heterochromatin island
namespace: cellular_component
def: "A region of facultative heterochromatin formed dynamically at specific loci in response to environmental signals, independently of RNAi." [PMID:22144463, PMID:24210919]
comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin islands are formed at meiotic genes during vegetative (mitotic) growth.
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:1990343
name: heterochromatin domain
namespace: cellular_component
def: "A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:23151475, PMID:24210919]
comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin domains preferentially assemble at sexual differentiation genes and retrotransposons.
synonym: "HOOD" EXACT [PMID:23151475]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:1990344
name: secondary cell septum biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division." [PMID:22891259]
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0140278 ! mitotic division septum assembly

[Term]
id: GO:1990346
name: BID-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, PMID:14634621]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990347
name: obsolete G*/A mismatch-specific adenine-DNA glycosylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite 8-oxoG in the template by adenine DNA glycosylase activity. The reaction leaves an apyrimidinic (AP) site." [PMID:24559510]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "G*/A mismatch-specific adenine-DNA glycosylase activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990348
name: obsolete G/A mismatch specific adenine DNA glycosylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite guanine in the template by adenine DNA glycosylase activity. The reaction leaves an apurinic AP site. I also requested same term but for Go/A mismatch. If you think it is better to make one term for mismatched adenine that is fine by me." [PMID:9737967]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "G/A mismatch specific adenine DNA glycosylase activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990349
name: gap junction-mediated intercellular transport
namespace: biological_process
def: "The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells." [GOC:hjd, PMID:14506308, PMID:23261543, Wikipedia:Gap_junction]
is_a: GO:0010496 ! intercellular transport

[Term]
id: GO:1990350
name: glucose transporter complex
namespace: cellular_component
def: "A protein complex facilitating glucose transport into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]
comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay).
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:1990351
name: transporter complex
namespace: cellular_component
def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]
comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay).
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990352
name: BRE1 E3 ubiquitin ligase complex
namespace: cellular_component
def: "A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes." [GOC:bhm, PMID:19531475]
comment: An example of this is BRE1 in Saccharomyces cerevisiae (UniProt symbol Q07457) in PMID:19531475 (inferred from direct assay).
synonym: "BRE1 E3 ubiquitin-protein ligase complex" EXACT []
synonym: "BRE1 oligomer" EXACT []
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:1990353
name: Fused-Smurf ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation." [GOC:bhm, PMID:21145463]
comment: An example of this is FUSED in Drosophila melanogaster (UniProt symbol P23647) in PMID:21145463 (inferred from direct assay).
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:1990354
name: activated SUMO-E1 ligase complex
namespace: cellular_component
def: "A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins." [GOC:bhm, PMID:15660128]
comment: An example of this is SAE1 in human (UniProt symbol Q9UBE0) in PMID:15660128 (inferred from direct assay).
synonym: "SUMO-SAE1/2 complex" NARROW []
is_a: GO:0106068 ! SUMO ligase complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:1990355
name: L-methionine salvage from methionine sulphoxide
namespace: biological_process
def: "The generation of L-methionine from methionine sulphoxide." [PMID:24118096]
synonym: "methionine salvage from methionine sulphoxide" BROAD []
is_a: GO:0071267 ! L-methionine salvage

[Term]
id: GO:1990356
name: obsolete sumoylated E2 ligase complex
namespace: cellular_component
def: "OBSOLETE. A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase." [GOC:bhm, PMID:18691969]
comment: This term was obsoleted because it is represents a complex with a modified (sumoylated) subunit; this is out of the scope of GO.
is_obsolete: true

[Term]
id: GO:1990357
name: terminal web
namespace: cellular_component
def: "An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells." [GOC:kmv, PMID:19437512, PMID:24677443, PMID:7511618, Wikipedia:Terminal_web]
is_a: GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:1990358
name: xylanosome
namespace: cellular_component
def: "A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose." [GOC:mengo_curators, PMID:16769147]
synonym: "xylanolytic complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1990359
name: stress response to zinc ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus." [GOC:kmv, PMID:17888400]
synonym: "response to zinc ion stress" EXACT []
synonym: "response to zinc toxicity" RELATED []
synonym: "stress response to zinc" BROAD []
is_a: GO:0010043 ! response to zinc ion
is_a: GO:0097501 ! stress response to metal ion

[Term]
id: GO:1990360
name: PKM2 protein kinase complex
namespace: cellular_component
def: "A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer." [GOC:bhm, PMID:24606918]
synonym: "PKM2-SAICAR complex" RELATED []
synonym: "PKM2-SAICAR protein kinase complex" RELATED []
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:1990361
name: PKM2 pyruvate kinase complex
namespace: cellular_component
def: "A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013)." [GOC:bhm, PMID:24606918]
comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay).
synonym: "PKM2 homotetramer" EXACT []
is_a: GO:1902912 ! pyruvate kinase complex

[Term]
id: GO:1990362
name: butanol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: butan-1-ol + NAD+ = butanal + H+ + NADH." [GOC:mengo_curators, PMID:1999395, RHEA:33199]
synonym: "butanol dehydrogenase activity" BROAD []
xref: RHEA:33199
is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity

[Term]
id: GO:1990363
name: obsolete response to hydrolysate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of hydrolysate (any product of hydrolysis)." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to hydrolysate" EXACT []
is_obsolete: true

[Term]
id: GO:1990364
name: obsolete response to aldehyde
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to aldehyde" EXACT []
is_obsolete: true

[Term]
id: GO:1990365
name: obsolete response to phenol
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phenols." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to phenol" EXACT []
is_obsolete: true

[Term]
id: GO:1990366
name: obsolete response to organic acid
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic acid." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to organic acid" EXACT []
is_obsolete: true

[Term]
id: GO:1990368
name: obsolete process resulting in tolerance to hydrolysate
namespace: biological_process
def: "OBSOLETE. A response that results in a state of tolerance to hydrolysate (product of hydrolysis)." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "process resulting in tolerance to hydrolysate" EXACT []
is_obsolete: true

[Term]
id: GO:1990370
name: obsolete process resulting in tolerance to aldehyde
namespace: biological_process
def: "OBSOLETE. A response that results in a state of tolerance to aldehyde." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted because it does not represent a clear process.
is_obsolete: true

[Term]
id: GO:1990371
name: obsolete process resulting in tolerance to phenol
namespace: biological_process
def: "OBSOLETE. A response that results in a state of tolerance to phenol." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted because it does not represent a clear process.
is_obsolete: true

[Term]
id: GO:1990372
name: obsolete process resulting in tolerance to organic acid
namespace: biological_process
def: "OBSOLETE. A response that results in a state of tolerance to organic acid." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted because it does not represent a clear process.
is_obsolete: true

[Term]
id: GO:1990374
name: Kir2 inward rectifier potassium channel complex
namespace: cellular_component
def: "A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells." [GOC:bhm, PMID:16834334]
comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay).
synonym: "Kir2.1 complex" NARROW []
is_a: GO:1902937 ! inward rectifier potassium channel complex

[Term]
id: GO:1990375
name: baculum development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure." [GOC:sl, PMID:21471296]
synonym: "os penis development" EXACT [GOC:sl]
synonym: "penile bone development" EXACT [GOC:sl]
synonym: "penis bone development" EXACT [GOC:sl]
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:1990376
name: obsolete negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation that results in negative regulation of mitotic G1/S transition." [PMID:9135083]
comment: This term was made obsolete because it would not be used for annotation.
is_obsolete: true

[Term]
id: GO:1990377
name: organomineral extracellular matrix
namespace: cellular_component
def: "An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight." [GOC:jh2, PMID:15994301]
comment: An example is found in shell calcitic prisms of the Mediterranean fan mussel Pinna nobilis (PMID:15994301), but the term may also be useful to annotate bone and eggshell proteins.
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:1990378
name: upstream stimulatory factor complex
namespace: cellular_component
def: "A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters." [GOC:bhm, PMID:8576131]
comment: An example of this is USF1 in human (UniProt symbol P22415) in PMID:8576131 (inferred from direct assay).
synonym: "USF complex" EXACT []
synonym: "USF1 homodimer" NARROW []
synonym: "USF1-USF2 heterodimer" NARROW []
synonym: "USF2 homodimer" NARROW []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990379
name: lipid transport across blood-brain barrier
namespace: biological_process
def: "The directed movement of lipid molecules passing through the blood-brain barrier." [GOC:sjp, PMID:24345162]
synonym: "lipid transport across blood brain barrier" EXACT []
is_a: GO:0006869 ! lipid transport
is_a: GO:0150104 ! transport across blood-brain barrier

[Term]
id: GO:1990380
name: K48-linked deubiquitinase activity
namespace: molecular_function
def: "Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]
synonym: "K48-specific deubiquitinase activity" EXACT []
synonym: "K48-specific deubiquitinating activity" EXACT [PMID:22970133]
synonym: "Lys48-specific deubiquitinase activity" EXACT [PMID:22970133]
xref: Reactome:R-HSA-5690870 "OTUD7B,TNFAIP3 deubiquitinate TRAF6"
xref: Reactome:R-HSA-9711058 "SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA"
is_a: GO:0101005 ! deubiquitinase activity

[Term]
id: GO:1990381
name: ubiquitin-specific protease binding
namespace: molecular_function
def: "Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]
synonym: "deubiquitinase binding" EXACT [GOC:bf]
synonym: "deubiquitinating enzyme binding" EXACT [PMID:24063750]
is_a: GO:0002020 ! protease binding

[Term]
id: GO:1990382
name: obsolete melanosome assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:bf, GOC:PARL, PMID:22511774]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "melanosome biogenesis" EXACT [PMID:22511774]
is_obsolete: true

[Term]
id: GO:1990383
name: cellular response to biotin starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin." [PMID:12557275]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:1990384
name: hyaloid vascular plexus regression
namespace: biological_process
def: "The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression." [GOC:hjd, PMID:18841878]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:1990385
name: meiotic spindle midzone
namespace: cellular_component
def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv, PMID:12707312]
is_a: GO:0051233 ! spindle midzone
relationship: part_of GO:0072687 ! meiotic spindle

[Term]
id: GO:1990386
name: mitotic cleavage furrow ingression
namespace: biological_process
def: "Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [GOC:kmv, PMID:12707312]
is_a: GO:0036090 ! cleavage furrow ingression
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:1990387
name: isogloboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides)." [GOC:hjd, PMID:22875802]
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:1990388
name: xylem-to-phloem iron transport
namespace: biological_process
def: "The directed movement of iron ions into the phloem from the xylem." [GOC:tb, PMID:24867923]
is_a: GO:0006826 ! iron ion transport
is_a: GO:0010233 ! phloem transport

[Term]
id: GO:1990389
name: CUE1-UBC7 ubiquitin-conjugating enzyme complex
namespace: cellular_component
def: "A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1." [GOC:bhm, PMID:23028185]
comment: An example of this is UBC7 in Saccharomyces cerevisiae (Q02159) in PMID:16179953 (inferred from direct assay).
synonym: "CUE1-UBC7 ubiquitin-conjugating enzyme (E2)" EXACT []
is_a: GO:0000835 ! ER ubiquitin ligase complex
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex

[Term]
id: GO:1990390
name: protein K33-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein." [PMID:24768539]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:1990391
name: DNA repair complex
namespace: cellular_component
def: "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]
synonym: "DNA damage repair complex" EXACT []
synonym: "WHY1 complex" NARROW []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:1990392
name: EFF-1 complex
namespace: cellular_component
def: "A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer." [GOC:bhm, PMID:24725407]
comment: An example of this is eff-1 in C. elegans (G5ECA1) in PMID:24725407 (inferred from direct assay).
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:1990393
name: 3M complex
namespace: cellular_component
def: "A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity." [PMID:24793695, PMID:24793696]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990394
name: cellular response to cell wall damage
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell." [PMID:17287531]
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:1990395
name: meiotic spindle pole body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body." [GOC:vw]
is_a: GO:0051300 ! spindle pole body organization
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0000212 ! meiotic spindle organization

[Term]
id: GO:1990396
name: single-strand break repair via homologous recombination
namespace: biological_process
def: "The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:bhm, PMID:24339919]
is_a: GO:0000012 ! single strand break repair
is_a: GO:0000725 ! recombinational repair
is_a: GO:0042275 ! error-free postreplication DNA repair

[Term]
id: GO:1990397
name: queuosine salvage
namespace: biological_process
def: "Any process which produces queuosine from derivatives of it, without de novo synthesis." [GOC:vw, PMID:24911101]
is_a: GO:0008616 ! queuosine biosynthetic process
is_a: GO:0043174 ! nucleoside salvage

[Term]
id: GO:1990398
name: Cus cation efflux complex
namespace: cellular_component
def: "Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth." [GOC:bhm, PMID:23122209]
comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209.
synonym: "copper efflux complex" NARROW []
synonym: "copper efflux system" NARROW []
synonym: "Cus cation efflux system" EXACT []
synonym: "silver efflux complex" NARROW []
synonym: "silver efflux system" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1903113 ! copper ion transmembrane transporter complex
is_a: GO:1903114 ! silver ion transmembrane transporter complex

[Term]
id: GO:1990399
name: epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed epithelium." [GOC:sl, PMID:19845688]
synonym: "regeneration of epithelium" EXACT []
is_a: GO:0042246 ! tissue regeneration
is_a: GO:0060429 ! epithelium development

[Term]
id: GO:1990400
name: mitochondrial ribosomal large subunit rRNA binding
namespace: molecular_function
def: "Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA)." [PMID:24206665]
comment: In S. cerevisiae, this is the mitochondrial 21S rRNA
synonym: "21S rRNA binding" NARROW []
synonym: "mitochondrial LSU rRNA binding" EXACT []
is_a: GO:0070180 ! large ribosomal subunit rRNA binding

[Term]
id: GO:1990401
name: embryonic lung development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure." [PMID:24785085]
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:1990402
name: embryonic liver development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure." [PMID:15918910]
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:1990403
name: embryonic brain development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure." [PMID:15918910]
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:1990404
name: NAD+-protein ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]
synonym: "NAD+ ADP-ribosyltransferase activity" BROAD []
synonym: "protein ADP-ribosylase activity" EXACT []
synonym: "protein ADP-ribosyltransferase activity" BROAD []
synonym: "ribosylase activity" BROAD []
xref: Wikipedia:ADP-ribosylation
is_a: GO:0016763 ! pentosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:1990405
name: protein antigen binding
namespace: molecular_function
def: "Binding to a protein antigen." [PMID:9360996]
is_a: GO:0003823 ! antigen binding
is_a: GO:0005515 ! protein binding

[Term]
id: GO:1990406
name: CGRP receptor complex
namespace: cellular_component
def: "A transmembrane, G protein-coupled signaling receptor complex recognized by calcitonin gene-related peptides (CGRP)." [GOC:bhm, PMID:20826335]
comment: An example of this is CALCRL in human (Q16602) in PMID:20826335 (inferred from direct assay).
synonym: "calcitonin gene-related polypeptide receptor complex" EXACT []
synonym: "Calcitonin-gene-related peptide receptor complex" EXACT []
synonym: "CGRP-R complex" EXACT []
is_a: GO:1903439 ! calcitonin family receptor complex

[Term]
id: GO:1990407
name: calcitonin gene-related peptide binding
namespace: molecular_function
def: "Binding to calcitonin gene-related peptide (CGRP)." [GOC:bhm, PMID:10882736]
comment: An example of this is CALCRL in human (Q16602) in PMID:10882736 (inferred from direct assay/mutant phenotype/etc.).
synonym: "calcitonin-gene-related peptide binding" EXACT []
synonym: "calcitonin-gene-related polypeptide binding" EXACT []
synonym: "CGRP polypeptide binding" EXACT []
is_a: GO:0097644 ! calcitonin family binding

[Term]
id: GO:1990408
name: calcitonin gene-related peptide receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers." [GOC:bhm, PMID:10882736]
comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736.
synonym: "calcitonin-gene-related peptide receptor signaling pathway" EXACT []
synonym: "calcitonin-gene-related polypeptide receptor signaling pathway" EXACT []
synonym: "CGRP receptor signaling pathway" EXACT []
is_a: GO:0097646 ! calcitonin family receptor signaling pathway

[Term]
id: GO:1990409
name: adrenomedullin binding
namespace: molecular_function
def: "Binding to adrenomedullin (AM)." [GOC:bhm, PMID:10882736]
comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736.
synonym: "AM binding" EXACT []
is_a: GO:0097644 ! calcitonin family binding

[Term]
id: GO:1990410
name: adrenomedullin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell." [GOC:bhm, PMID:10882736]
comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736.
synonym: "AM receptor signaling pathway" EXACT []
is_a: GO:0097646 ! calcitonin family receptor signaling pathway

[Term]
id: GO:1990411
name: hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
namespace: molecular_function
def: "Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium." [PMID:24828577]
xref: MetaCyc:RXN-14428
xref: RHEA:42688
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:1990412
name: obsolete hercynylselenocysteine lyase activity (selenoneine-forming)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium." [PMID:24828577]
comment: This term was obsoleted based on PMID:36071162 that has demonstrated that this reaction does not take place.
is_obsolete: true

[Term]
id: GO:1990413
name: eyespot apparatus
namespace: cellular_component
def: "A small pigmented organelle used in single-celled organisms to detect light." [Wikipedia:Eyespot_apparatus]
synonym: "eyespot" RELATED []
synonym: "stigma" RELATED []
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:1990414
name: replication-born double-strand break repair via sister chromatid exchange
namespace: biological_process
def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]
synonym: "replication-born DSB repair by SCE" EXACT []
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:1990416
name: cellular response to brain-derived neurotrophic factor stimulus
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus." [PMID:21958434]
synonym: "cellular response to BDNF stimulus" EXACT []
is_a: GO:1990090 ! cellular response to nerve growth factor stimulus

[Term]
id: GO:1990417
name: snoRNA release from pre-rRNA
namespace: biological_process
def: "The release of snoRNA from pre-rRNA." [GOC:rb, PMID:16908538]
comment: An example of this process is yeast HAS1 from PMID:16908538, inferred from mutant phenotype assay.
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:1990418
name: response to insulin-like growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:21932665]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:1990419
name: obsolete response to elemental metal
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an elemental metal stimulus." [PMID:22688007]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to elemental metal" EXACT []
is_obsolete: true

[Term]
id: GO:1990420
name: establishment of septation initiation network asymmetry
namespace: biological_process
def: "The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies." [PMID:22786806]
synonym: "establishment of SIN asymmetry" EXACT [PMID:22786806]
is_a: GO:0031028 ! septation initiation signaling

[Term]
id: GO:1990422
name: glyoxalase (glycolic acid-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor." [GOC:bf, GOC:PARL, PMID:22523093]
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:1990423
name: RZZ complex
namespace: cellular_component
def: "A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]
comment: Example annotations for this term would be D. melanogaster mit(1)15 (Q9W4X9), rod and zwilch (Q9VA00).
synonym: "Rod-Zwilch-Zw10 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:1990424
name: protein arginine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate." [GOC:imk, PMID:22517742]
comment: This reaction occurs in bacterial species e.g. Bacillus subtilis.
synonym: "protein-arginine kinase activity" EXACT []
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:1990425
name: ryanodine receptor complex
namespace: cellular_component
def: "A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom." [GOC:ame, PMID:22822064]
comment: An example of this is RyR1 in rabbit (P11716) in PMID:2550460 (inferred from electron microscopy).
synonym: "RyR" RELATED []
is_a: GO:0005891 ! voltage-gated calcium channel complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:1990426
name: mitotic recombination-dependent replication fork processing
namespace: biological_process
alt_id: GO:1903211
def: "Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:mah, PMID:23093942]
synonym: "homologous recombination dependent replication fork recovery" RELATED [PMID:23093942]
synonym: "homologous recombination-dependent replication fork processing" EXACT []
synonym: "mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie]
synonym: "mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie]
synonym: "mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie]
synonym: "mitotic recombination involved in replication fork processing" RELATED []
synonym: "mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie]
synonym: "mitotic recombination involved in replication restart" RELATED [GOC:TermGenie]
is_a: GO:0031297 ! replication fork processing
is_a: GO:1990505 ! mitotic DNA replication maintenance of fidelity

[Term]
id: GO:1990427
name: stereocilia tip-link density
namespace: cellular_component
def: "An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane." [PMID:19447093, PMID:21709241]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0002140 ! stereocilia tip link
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:1990428
name: miRNA transport
namespace: biological_process
def: "The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GO:jl, PMID:24356509]
synonym: "microRNA transport" EXACT []
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:1990429
name: peroxisomal importomer complex
namespace: cellular_component
alt_id: GO:1990415
def: "A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831]
synonym: "peroxisomal import pore" EXACT []
synonym: "peroxisomal protein import machinery" EXACT []
synonym: "Pex14 complex" NARROW []
synonym: "Pex17p-Pex14p docking complex" RELATED []
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:1990430
name: extracellular matrix protein binding
namespace: molecular_function
def: "Binding to a protein that is part of an extracellular matrix." [PMID:22355679]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:1990431
name: priRNA 3'-end processing
namespace: biological_process
def: "The process of forming the mature 3' end of a priRNA molecule." [PMID:24095277]
synonym: "primal small RNA 3'-end processing" EXACT []
synonym: "priRNA 3' end processing" EXACT []
is_a: GO:0043628 ! regulatory ncRNA 3'-end processing

[Term]
id: GO:1990432
name: siRNA 3'-end processing
namespace: biological_process
def: "The process of forming the mature 3' end of a siRNA molecule." [PMID:24095277]
synonym: "siRNA 3' end processing" EXACT []
synonym: "small interfering RNA 3'-end processing" EXACT []
is_a: GO:0043628 ! regulatory ncRNA 3'-end processing

[Term]
id: GO:1990433
name: CSL-Notch-Mastermind transcription factor complex
namespace: cellular_component
def: "A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes." [GOC:bhm, GOC:dos, PMID:16530045]
synonym: "CSL-NotchIC-MASTERMIND complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990434
name: lower tip-link density
namespace: cellular_component
def: "An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises." [PMID:19447093]
synonym: "LTLD" EXACT []
is_a: GO:1990427 ! stereocilia tip-link density

[Term]
id: GO:1990435
name: upper tip-link density
namespace: cellular_component
def: "An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends." [PMID:19447093]
synonym: "UTLD" EXACT []
is_a: GO:1990427 ! stereocilia tip-link density

[Term]
id: GO:1990436
name: obsolete MAPK cascade involved in oxidative stress signaling pathway
namespace: biological_process
def: "OBSOLETE. The series of molecular signals in which a MAP kinase cascade activated by oxidative stress relays one or more of the signals, MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Just FYI in pombe the osmotic stress and oxidative stress MAPK cascade involve many of the same proteins, but the pathways are slightly different, therefore Im req this term." [PMID:10398679]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "MAPK cascade involved in oxidative stress signaling pathway" EXACT []
is_obsolete: true

[Term]
id: GO:1990437
name: snRNA 2'-O-methylation
namespace: biological_process
def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule." [PMID:11842100, PMID:9844635]
is_a: GO:0106349 ! snRNA methylation

[Term]
id: GO:1990438
name: U6 2'-O-snRNA methylation
namespace: biological_process
def: "The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule." [PMID:11842100, PMID:9844635]
is_a: GO:1990437 ! snRNA 2'-O-methylation

[Term]
id: GO:1990439
name: MAP kinase serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate." [PMID:10398679]
is_a: GO:0004722 ! protein serine/threonine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity

[Term]
id: GO:1990440
name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf]
synonym: "ER stress-induced upregulation of transcription" BROAD [GOC:bf]
synonym: "stimulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf]
synonym: "up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "up-regulation of transcription induced by ER stress" BROAD [GOC:bf, PMID:21113145]
synonym: "upregulation of Pol II transcription induced by ER stress" EXACT [GOC:bf, PMID:21113145]
synonym: "upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
is_obsolete: true
consider: GO:0034976
consider: GO:0045944

[Term]
id: GO:1990441
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "down-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "ER stress-induced negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "inhibition of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "negative regulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf]
synonym: "reduction of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145]
synonym: "repression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145]
synonym: "suppression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145]
is_obsolete: true
consider: GO:0000122
consider: GO:0034976

[Term]
id: GO:1990442
name: intrinsic apoptotic signaling pathway in response to nitrosative stress
namespace: biological_process
def: "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:bf, GOC:PARL, PMID:23985028]
synonym: "nitrosative stress-induced apoptosis" RELATED [PMID:23985028]
synonym: "nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
is_a: GO:0071500 ! cellular response to nitrosative stress
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:1990443
name: peptidyl-threonine autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein." [PMID:7803855]
subset: gocheck_obsoletion_candidate
is_a: GO:0018107 ! peptidyl-threonine phosphorylation
is_a: GO:0046777 ! protein autophosphorylation

[Term]
id: GO:1990444
name: F-box domain binding
namespace: molecular_function
def: "Binding to an F-box domain of a protein." [GOC:bf, GOC:PARL, InterPro:IPR001810, PMID:12628165]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990445
name: obsolete Multiciliate cell differentiation
namespace: biological_process
def: "OBSOLETE. The process in which a relatively unspecialized cell acquires features of a multiciliated cell, a specialized epithelial cell type that extends anywhere from 150 to 200 motile cilia per cell in order to produce a vigorous fluid flow critical to human health in several organ systems." [PMID:22231168, PMID:24934224]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "Multiciliate cell differentiation" EXACT []
is_obsolete: true

[Term]
id: GO:1990446
name: U1 snRNP binding
namespace: molecular_function
def: "Binding to a U1 small nuclear ribonucleoprotein particle." [PMID:14713954]
is_a: GO:0070990 ! snRNP binding

[Term]
id: GO:1990447
name: U2 snRNP binding
namespace: molecular_function
def: "Binding to a U2 small nuclear ribonucleoprotein particle." [PMID:14713954]
is_a: GO:0070990 ! snRNP binding

[Term]
id: GO:1990448
name: exon-exon junction complex binding
namespace: molecular_function
def: "Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [GOC:sart, PMID:24967911]
synonym: "EJC binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1990449
name: obsolete amylin receptor
namespace: cellular_component
def: "OBSOLETE. A G protein-coupled signalling receptor complex consisting of the calcitonin receptor and a receptor activity-modifying protein (RAMP). Amylin is produced in beta-islet cells of the pancreas. It is implicated in selective inhibition of insulin-stimulated glucose utilization and glycogen deposition in muscle, gastric emptying, gastric acid secretion, postprandial glucagon secretion and food intake and aids weight loss." [GOC:bhm, PMID:10871269]
comment: An example of this is CALCR in human (P30988) in PMID:10871269.
synonym: "AMY1 receptor" NARROW []
synonym: "AMY2 receptor" NARROW []
synonym: "AMY3 receptor" NARROW []
synonym: "amylin receptor" EXACT []
synonym: "CALCR-RAMP1 receptor" NARROW []
synonym: "CALCR-RAMP2 receptor" NARROW []
synonym: "CALCR-RAMP3 receptor" NARROW []
is_obsolete: true

[Term]
id: GO:1990450
name: linear polyubiquitin binding
namespace: molecular_function
def: "Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next." [GOC:bf, GOC:PARL, PMID:23453807]
synonym: "M1-linked ubiquitin chain binding" EXACT [PMID:23453807]
is_a: GO:0043130 ! ubiquitin binding

[Term]
id: GO:1990451
name: cellular stress response to acidic pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution." [GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049]
comment: An example of this is NOX1 in human (Q9Y5S8) in PMID:10615049.
synonym: "cellular stress response to acidity" BROAD []
is_a: GO:0062197 ! cellular response to chemical stress
is_a: GO:0071468 ! cellular response to acidic pH

[Term]
id: GO:1990452
name: Parkin-FBXW7-Cul1 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165]
synonym: "Park2-FBXW7-Cul1 complex" EXACT [GOC:bf]
synonym: "Parkin-FBXW7-Cul1 protein complex" EXACT [GOC:bf]
synonym: "Parkin-HSel-10-Cullin-1 complex" NARROW [PMID:12628165]
synonym: "Parkin/Cul1/F-box protein complex" EXACT [GOC:bf]
synonym: "PRKN-FBXW7-Cul1 complex" EXACT []
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:1990453
name: nucleosome disassembly/reassembly complex
namespace: cellular_component
def: "A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex." [GOC:bhm, PMID:24843044]
comment: An example of this is EAF7 in Saccharomyces cerevisiae (P53911) in PMID:24843044 (inferred from direct assay).
synonym: "eaf5/7/3 complex" NARROW []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:1990454
name: L-type voltage-gated calcium channel complex
namespace: cellular_component
def: "A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation." [GOC:ame, PMID:12946355]
comment: Examples of this are CACNA1S, CACNA2D1, CACNB1, CACNG1 in rabbit (UniProt symbol P07293, P13806, P19517 and P19518) in PMID:12946355 (inferred from direct assay).
synonym: "cardiac muscle L-type voltage-gated calcium channel complex" NARROW []
synonym: "skeletal muscle L-type voltage-gated calcium channel complex" NARROW []
is_a: GO:0005891 ! voltage-gated calcium channel complex
relationship: part_of GO:0030315 ! T-tubule

[Term]
id: GO:1990455
name: PTEN phosphatase complex
namespace: cellular_component
def: "A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function." [GOC:bhm, PMID:24766807]
comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
synonym: "phosphatase and tensin homolog" EXACT []
synonym: "phosphatase and tensin homolog deleted on chromosome ten homodimer" EXACT []
synonym: "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer" EXACT []
is_a: GO:1904144 ! phosphatidylinositol phosphate phosphatase complex

[Term]
id: GO:1990456
name: mitochondrion-endoplasmic reticulum membrane tethering
namespace: biological_process
def: "The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:19556461, PMID:27875684]
synonym: "mitochondrion-endoplasmic reticulum attachment" EXACT []
synonym: "mitochondrion-endoplasmic reticulum tethering" EXACT []
synonym: "mitochondrion-ER attachment" EXACT []
synonym: "mitochondrion-ER membrane tethering" EXACT []
synonym: "mitochondrion-ER tethering" EXACT []
is_a: GO:0016043 ! cellular component organization
is_a: GO:0140056 ! organelle localization by membrane tethering

[Term]
id: GO:1990457
name: pexophagosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy." [PMID:22536249]
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:1990458
name: lipooligosaccharide binding
namespace: molecular_function
def: "Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria." [GOC:hjd, PMID:8894399]
comment: ChEBI distinguishes an oligosaccharide from a polysaccharide as the latter being anything of length 10 or greater.
synonym: "endotoxin binding" RELATED []
synonym: "LOS binding" RELATED []
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:1990459
name: transferrin receptor binding
namespace: molecular_function
def: "Binding to a transferrin receptor." [GOC:pm, PMID:9819414]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:1990460
name: leptin receptor binding
namespace: molecular_function
def: "Binding to a leptin receptor." [GOC:pm, PMID:22405007]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:1990461
name: detoxification of iron ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion." [GOC:sart, PMID:23064556]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0010039 ! response to iron ion

[Term]
id: GO:1990462
name: omegasome
namespace: cellular_component
def: "Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites." [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:1990463
name: lateral cortical node
namespace: cellular_component
def: "A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins." [GOC:mah, PMID:25009287]
synonym: "Skb1-containing cortical node" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0097575 ! lateral cell cortex

[Term]
id: GO:1990464
name: D-2-hydroxyacid dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol." [PMID:3013300, PMID:4582730, RHEA:11272]
comment: (R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors.
synonym: "(R)-2-hydroxy acid dehydrogenase activity" RELATED [EC:1.1.5.10]
synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.5.10]
synonym: "(R)-2-hydroxyacid:quinone oxidoreductase activity" RELATED [EC:1.1.5.10]
synonym: "D-lactate dehydrogenase (quinone) activity" RELATED [GOC:am]
synonym: "D-lactate dehydrogenase activity" RELATED [EC:1.1.5.10]
synonym: "D-lactate:quinone oxidoreductase activity" RELATED [GOC:am]
xref: EC:1.1.5.10
xref: MetaCyc:RXN-14931
xref: RHEA:11272
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:1990465
name: obsolete aldehyde oxygenase (deformylating) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction a long-chain aldehyde + O2 + 2 NADPH = an alkane + formate + H2O + 2 NADP+." [GOC:mengo_curators, PMID:22947199]
comment: This term was obsoleted because it represents the same reaction as aldehyde decarbonylase activity ; GO:0071771.
is_obsolete: true
replaced_by: GO:0071771

[Term]
id: GO:1990466
name: protein autosumoylation
namespace: biological_process
def: "The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [PMID:21518767, PMID:23443663]
subset: gocheck_do_not_annotate
synonym: "protein auto-sumoylation" EXACT []
synonym: "protein self-sumoylation" EXACT []
is_a: GO:0016925 ! protein sumoylation

[Term]
id: GO:1990467
name: NuA3a histone acetyltransferase complex
namespace: cellular_component
def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p." [GOC:rb, PMID:25104842]
is_a: GO:0033100 ! NuA3 histone acetyltransferase complex

[Term]
id: GO:1990468
name: NuA3b histone acetyltransferase complex
namespace: cellular_component
def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p." [GOC:rb, PMID:25104842]
is_a: GO:0033100 ! NuA3 histone acetyltransferase complex

[Term]
id: GO:1990469
name: Rhino-Deadlock-Cutoff Complex
namespace: cellular_component
def: "Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation." [GOC:bhm, PMID:24906153]
comment: An example of this is cuff in Drosophila melanogaster (Q9V629) in PMID:24906153.
synonym: "RDC complex" EXACT []
synonym: "rhi-del-cuff complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1990923 ! PET complex
relationship: part_of GO:0043073 ! germ cell nucleus

[Term]
id: GO:1990470
name: piRNA cluster binding
namespace: molecular_function
def: "Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)." [GOC:bhm, PMID:24906153]
comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay).
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:1990471
name: piRNA uni-strand cluster binding
namespace: molecular_function
def: "Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa." [GOC:bhm, PMID:24906153]
is_a: GO:1990470 ! piRNA cluster binding

[Term]
id: GO:1990472
name: piRNA dual-strand cluster binding
namespace: molecular_function
def: "Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription." [GOC:bhm, PMID:24906153]
comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay).
is_a: GO:1990470 ! piRNA cluster binding

[Term]
id: GO:1990473
name: ciliary targeting signal binding
namespace: molecular_function
def: "Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane." [GOC:krc, PMID:18256283, PMID:19575670, PMID:20603001, PMID:20697559]
synonym: "CTS binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:1990474
name: synaptic vesicle, readily releasable pool
namespace: cellular_component
def: "A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton." [GOC:pad, PMID:22745285]
synonym: "readily releasable pool of synaptic vesicles" EXACT []
synonym: "RRP" RELATED []
is_a: GO:0008021 ! synaptic vesicle
relationship: part_of GO:0043195 ! terminal bouton

[Term]
id: GO:1990475
name: synaptic vesicle, recycling pool
namespace: cellular_component
def: "A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state." [GOC:pad, PMID:22745285]
synonym: "recycling pool of synaptic vesicles" EXACT []
is_a: GO:0008021 ! synaptic vesicle
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:1990476
name: synaptic vesicle, resting pool
namespace: cellular_component
def: "A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation causes a saturating degree of vesicular turnover. 50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool." [GOC:pad, PMID:22745285]
synonym: "reserve pool of synaptic vesicles" EXACT [PMID:15611727]
synonym: "resting pool of synaptic vesicles" EXACT []
is_a: GO:0008021 ! synaptic vesicle
relationship: part_of GO:0043195 ! terminal bouton

[Term]
id: GO:1990477
name: MTREC complex
namespace: cellular_component
alt_id: GO:1990345
def: "Protein complex formed by an RNA binding protein Red1, an RNA helicase Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2. This complex is required for the recruitment of the nuclear exosome to Mmi1 nuclear focus. It is likely related to the human CBCN complex. This complex is also known as RNA silencing (NURS) complex." [PMID:24210919, PMID:24713849, PMID:32012158]
synonym: "Mtl1-Red1 core complex" EXACT [PMID:24210919]
synonym: "NURS complex" EXACT []
synonym: "PAXT complex" EXACT []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:1990478
name: response to ultrasound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus." [PMID:20950932]
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:1990479
name: obsolete response to lipoic acid
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [PMID:23232760]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to 5-(1,2-dithiolan-3-yl)pentanoic acid" EXACT []
is_obsolete: true

[Term]
id: GO:1990480
name: obsolete geranyl diphosphate synthase
namespace: molecular_function
def: "OBSOLETE. Catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene biosynthesis." [GOC:mengo_curators, PMID:10557273]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
replaced_by: GO:0004161

[Term]
id: GO:1990481
name: mRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]
synonym: "mRNA pseudouridylation" EXACT []
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0016556 ! mRNA modification

[Term]
id: GO:1990482
name: sphingolipid alpha-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC." [GOC:tb, PMID:25122154]
synonym: "inositol phosphorylceramide glucuronosyltransferase activity" RELATED []
is_a: GO:0008194 ! UDP-glycosyltransferase activity

[Term]
id: GO:1990483
name: obsolete Clr6 histone deacetylase complex I''
namespace: cellular_component
def: "OBSOLETE. A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3." [PMID:25002536]
comment: The reason for obsoletion is that there is no evidence that this function/process/component exists.
is_obsolete: true

[Term]
id: GO:1990484
name: aerobic lactate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen." [GOC:mengo_curators, PMID:8941775]
synonym: "aerobic lactic acid catabolic process" RELATED []
is_a: GO:1903457 ! lactate catabolic process

[Term]
id: GO:1990485
name: anaerobic lactate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen." [GOC:mengo_curators, PMID:11133436]
synonym: "anaerobic lactic acid catabolic process" RELATED []
is_a: GO:1903457 ! lactate catabolic process

[Term]
id: GO:1990486
name: anaerobic fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mengo_curators, PMID:17329794]
synonym: "anaerobic fatty acid degradation" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process

[Term]
id: GO:1990487
name: anaerobic lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units." [DOI:10.1039/C3EE40932E, GOC:mengo_curators]
synonym: "anaerobic lignin degradation" EXACT []
is_a: GO:0046274 ! lignin catabolic process

[Term]
id: GO:1990488
name: anaerobic cellulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen." [GOC:mengo_curators, PMID:8561466]
synonym: "anaerobic cellulose degradation" EXACT []
is_a: GO:0030245 ! cellulose catabolic process

[Term]
id: GO:1990489
name: anaerobic pectin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen." [GOC:mengo_curators, PMID:23079077]
synonym: "anaerobic pectin degradation" EXACT []
is_a: GO:0045490 ! pectin catabolic process

[Term]
id: GO:1990490
name: archaeal proton-transporting A-type ATPase complex
namespace: cellular_component
def: "A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea." [GOC:mengo_curators, PMID:15473999, PMID:24650628]
synonym: "A-type ATPase protein complex" BROAD []
synonym: "archaeal A-type ATPase protein complex" BROAD []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
is_a: GO:1904949 ! ATPase complex

[Term]
id: GO:1990491
name: methane biosynthetic process from methanol and hydrogen
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen." [GOC:mengo_curators, PMID:16347126]
synonym: "methane biosynthesis from methanol and hydrogen" EXACT []
synonym: "methanogenesis from methanol and hydrogen" EXACT []
is_a: GO:0019387 ! methanogenesis, from methanol
is_a: GO:1902421 ! hydrogen metabolic process

[Term]
id: GO:1990492
name: obsolete mitotic cell cycle checkpoint inhibiting CAR assembly
namespace: biological_process
def: "OBSOLETE. A Mad2-dependent mitotic cell cycle checkpoint which delays cytokinetic actinomycin ring assembly if there is a delay in early M-phase." [PMID:12186944]
comment: This term was obsoleted because it does not represent a specific process.
synonym: "Mad2-dependent mitotic cell cycle checkpoint" RELATED [GOC:dph, GOC:vw]
synonym: "mitotic cell cycle checkpoint inhibiting cytokinetic actomyosin ring assembly" EXACT []
is_obsolete: true

[Term]
id: GO:1990493
name: obsolete cyclin H-CDK7 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:9857180]
comment: This term was made obsolete because it was added in error.
synonym: "cyclin H-CDK7 complex" EXACT []
is_obsolete: true

[Term]
id: GO:1990494
name: obsolete regulation of mitotic cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cytokinesis, actomyosin contractile ring assembly." [PMID:18256290]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
is_obsolete: true

[Term]
id: GO:1990495
name: obsolete actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. An actin filament organization process that contributes to actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:8834798]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT []
is_obsolete: true

[Term]
id: GO:1990496
name: obsolete regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. An actin filament organization process that contributes to regulation of actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:24798735]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT []
is_obsolete: true

[Term]
id: GO:1990497
name: regulation of cytoplasmic translation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445]
is_a: GO:0043555 ! regulation of translation in response to stress
is_a: GO:2000765 ! regulation of cytoplasmic translation

[Term]
id: GO:1990498
name: mitotic spindle microtubule
namespace: cellular_component
def: "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw]
is_a: GO:0005876 ! spindle microtubule
relationship: part_of GO:0072686 ! mitotic spindle

[Term]
id: GO:1990499
name: raps-insc complex
namespace: cellular_component
def: "Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2)." [GOC:bhm, PMID:22171003]
comment: An example of this is Insc in drome (Q9W2R4) in PMID:22171003 (inferred from physical interaction).
synonym: "partner of inscuteable-inscuteable complex" EXACT []
synonym: "Rapsynoid-Inscuteable complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0045179 ! apical cortex

[Term]
id: GO:1990500
name: eif4e-cup complex
namespace: cellular_component
def: "A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo." [GOC:bhm, PMID:14723848]
comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction).
synonym: "eukaryotic translation initiation factor 4E-cup complex" EXACT []
is_a: GO:1903502 ! translation repressor complex
relationship: part_of GO:0000932 ! P-body

[Term]
id: GO:1990501
name: exon-exon junction subcomplex mago-y14
namespace: cellular_component
def: "Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA." [GOC:bhm, PMID:12730685]
comment: An example of this is Mago in drome (P49028) in PMID:12730685 (inferred from direct assay).
synonym: "exon junction subcomplex MAGOH-Y14" EXACT [GOC:bhm]
synonym: "mago-y14 complex" RELATED []
synonym: "MGN-RBM8A complex" EXACT []
is_a: GO:0035145 ! exon-exon junction complex
is_a: GO:1903503 ! ATPase inhibitor complex

[Term]
id: GO:1990502
name: dense core granule maturation
namespace: biological_process
def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674]
synonym: "dense core vesicle maturation" EXACT []
is_a: GO:0061792 ! secretory granule maturation

[Term]
id: GO:1990503
name: dendritic lamellar body
namespace: cellular_component
def: "A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions." [PMID:7869120]
synonym: "DLB" EXACT []
is_a: GO:0042599 ! lamellar body
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:1990504
name: dense core granule exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208]
synonym: "dense core vesicle exocytosis" EXACT []
is_a: GO:0017156 ! calcium-ion regulated exocytosis
is_a: GO:0032253 ! dense core granule localization
is_a: GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:1990505
name: mitotic DNA replication maintenance of fidelity
namespace: biological_process
alt_id: GO:1990510
def: "Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication." [PMID:19185548]
synonym: "maintenance of fidelity involved in mitotic cell cycle DNA replication" EXACT []
synonym: "maintenance of fidelity involved in mitotic DNA replication" EXACT []
is_a: GO:1902298 ! cell cycle DNA replication maintenance of fidelity
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1990506
name: mitotic DNA-templated DNA replication
namespace: biological_process
def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle." [PMID:16120966]
synonym: "mitotic DNA-dependent DNA replication" EXACT []
is_a: GO:1902969 ! mitotic DNA replication

[Term]
id: GO:1990507
name: obsolete ATP-independent chaperone mediated protein folding
namespace: biological_process
def: "OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis." [GOC:rb, PMID:25242142]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183

[Term]
id: GO:1990508
name: CKM complex
namespace: cellular_component
def: "Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8." [GOC:bhm, PMID:12200444]
comment: An example of this is SSN2 in Saccharomyces cerevisiae (P38931) in PMID:12200444 (inferred from physical interaction).
synonym: "CDK8 kinase module" EXACT []
synonym: "SRB8-SRB11 complex" EXACT []
synonym: "SRB8/9/10/11 complex" EXACT []
is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:1990509
name: PYM-mago-Y14 complex
namespace: cellular_component
def: "Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans." [GOC:bhm, PMID:14968132]
comment: An example of this is wibg in Drosophila melanogaster (P82804) in PMID:14968132 (inferred from physical interaction).
synonym: "PYM-mago-RNA-binding protein 8A complex" EXACT []
synonym: "wibg-mago-tsu complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990512
name: Cry-Per complex
namespace: cellular_component
def: "Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms." [GOC:bhm, PMID:24855952]
comment: An example of this is Cry1 in mouse (P97784) in PMID:24855952 (inferred from physical interaction).
is_a: GO:0017053 ! transcription repressor complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:1990513
name: CLOCK-BMAL transcription complex
namespace: cellular_component
def: "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms." [GOC:bhm, PMID:23229515]
comment: An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
synonym: "CLOCK/BMAL complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990514
name: 5' transitive RNA interference
namespace: biological_process
def: "An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430]
is_a: GO:0036453 ! transitive RNA interference

[Term]
id: GO:1990515
name: 3' transitive RNA interference
namespace: biological_process
def: "An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430]
is_a: GO:0036453 ! transitive RNA interference

[Term]
id: GO:1990516
name: ribonucleotide excision repair
namespace: biological_process
def: "The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase." [PMID:12475934, PMID:22864116]
is_a: GO:0070716 ! mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication

[Term]
id: GO:1990517
name: obsolete protein localization to photoreceptor outer segment
namespace: biological_process
def: "OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium." [GOC:krc, PMID:20212494]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990518
name: single-stranded 3'-5' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'." [PMID:25165823]
is_a: GO:0017116 ! single-stranded DNA helicase activity
is_a: GO:0043138 ! 3'-5' DNA helicase activity

[Term]
id: GO:1990519
name: pyrimidine nucleotide import into mitochondrion
namespace: biological_process
def: "The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix." [PMID:16194150]
synonym: "mitochondrial pyrimidine nucleotide import" EXACT []
is_a: GO:0006864 ! pyrimidine nucleotide transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
is_a: GO:0170036 ! import into the mitochondrion
is_a: GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:1990520
name: separase-securin complex
namespace: cellular_component
def: "A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC)." [GOC:dos, GOC:vw, PMID:8978688]
synonym: "Cut1-2 complex" EXACT [PMID:8978688]
is_a: GO:1905369 ! endopeptidase complex

[Term]
id: GO:1990521
name: obsolete m7G(5')pppN diphosphatase activator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and increases the activity of m7G(5')pppN diphosphatase." [PMID:22323607]
comment: This term was obsoleted because the obsoleted EC was obsoleted.
is_obsolete: true

[Term]
id: GO:1990522
name: tail spike morphogenesis
namespace: biological_process
def: "The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death." [GOC:kmv, PMID:17329362, PMID:6684600]
xref: WBbt:0006979
xref: WBbt:0008072
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:1990523
name: bone regeneration
namespace: biological_process
def: "The regrowth of bone following its loss or destruction." [PMID:25257467]
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:1990524
name: INA complex
namespace: cellular_component
def: "A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p." [GOC:rn, PMID:24942160]
synonym: "INAC" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:1990525
name: BIR domain binding
namespace: molecular_function
def: "Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain." [GOC:ha, InterPro:IPR001370]
comment: An example of this is the Drosophila reaper gene in PMID:21886178.
synonym: "Baculovirus Inhibitor of apoptosis protein Repeat domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990526
name: Ste12p-Dig1p-Dig2p complex
namespace: cellular_component
def: "A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae." [GOC:rb, PMID:16782869]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990527
name: Tec1p-Ste12p-Dig1p complex
namespace: cellular_component
def: "A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae." [GOC:rb, PMID:16782869]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990528
name: Rvs161p-Rvs167p complex
namespace: cellular_component
def: "A protein complex that is involved in endocytosis in the yeast S. cerevisiae." [GOC:rb, PMID:20610658]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990529
name: glycosylphosphatidylinositol-mannosyltransferase I complex
namespace: cellular_component
def: "A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M." [GOC:dph, GOC:rb, PMID:15635094]
synonym: "GPI-MT-I complex" RELATED []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex

[Term]
id: GO:1990530
name: Cdc50p-Drs2p complex
namespace: cellular_component
def: "A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome." [GOC:rb, PMID:15090616, PMID:22234261]
is_a: GO:1990531 ! phospholipid-translocating ATPase complex

[Term]
id: GO:1990531
name: phospholipid-translocating ATPase complex
namespace: cellular_component
def: "A protein complex that functions as a phospholipid-translocating P-Type ATPase." [GOC:dph, GOC:rb, PMID:15090616]
synonym: "aminophospholipid translocase complex" EXACT []
synonym: "APLT complex" EXACT []
synonym: "CDC50-DRS2 complex" NARROW []
synonym: "CRF1-DNF3 complex" NARROW []
synonym: "Dnf1-Lem3 complex" NARROW []
synonym: "Dnf2-Lem3 complex" NARROW []
synonym: "DNF3-CRF1 complex" NARROW []
synonym: "DRS2-CDC50 complex" NARROW []
synonym: "Lem3-Dnf1 complex" NARROW []
synonym: "Lem3p-Dnf1p complex" NARROW []
synonym: "P4-ATPase complex" EXACT []
synonym: "phospholipid flippase complex" EXACT []
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:1990532
name: stress response to nickel ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus." [GOC:kmv, PMID:25330323]
synonym: "response to nickel ion stress" EXACT []
synonym: "response to nickel toxicity" EXACT []
synonym: "stress response to nickel" EXACT []
is_a: GO:0097501 ! stress response to metal ion

[Term]
id: GO:1990533
name: Dom34-Hbs1 complex
namespace: cellular_component
def: "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay." [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425]
synonym: "Dom34:Hbs1 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990534
name: thermospermine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine." [PMID:24906355, RHEA:57836]
xref: RHEA:57836
is_a: GO:0046592 ! polyamine oxidase activity

[Term]
id: GO:1990535
name: neuron projection maintenance
namespace: biological_process
def: "The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:kmv, PMID:25359212]
synonym: "axon homeostasis" RELATED []
synonym: "axon maintenance" RELATED []
synonym: "neurite maintenance" NARROW []
synonym: "neuron process maintenance" EXACT []
synonym: "neuron protrusion maintenance" EXACT []
synonym: "neuronal cell projection maintenance" EXACT []
is_a: GO:0106027 ! neuron projection organization

[Term]
id: GO:1990536
name: phosphoenolpyruvate transmembrane import into Golgi lumen
namespace: biological_process
def: "The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane." [PMID:25195688]
is_a: GO:0089722 ! phosphoenolpyruvate transmembrane transport

[Term]
id: GO:1990537
name: mitotic spindle polar microtubule
namespace: cellular_component
def: "Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone." [PMID:16079915]
is_a: GO:0005827 ! polar microtubule
is_a: GO:1990498 ! mitotic spindle microtubule

[Term]
id: GO:1990538
name: xylan O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan." [PMID:25141999]
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:1990539
name: fructose import across plasma membrane
namespace: biological_process
alt_id: GO:0032445
def: "The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857]
synonym: "fructose import" RELATED []
synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015755 ! fructose transmembrane transport
is_a: GO:0140271 ! hexose import across plasma membrane

[Term]
id: GO:1990540
name: mitochondrial manganese ion transmembrane transport
namespace: biological_process
def: "The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:12890866]
is_a: GO:0071421 ! manganese ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990542
name: mitochondrial transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:1990543
name: mitochondrial S-adenosyl-L-methionine transmembrane transport
namespace: biological_process
def: "The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:14609944]
is_a: GO:1901962 ! S-adenosyl-L-methionine transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990544
name: mitochondrial ATP transmembrane transport
namespace: biological_process
def: "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069]
is_a: GO:0015867 ! ATP transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990545
name: mitochondrial thiamine pyrophosphate transmembrane transport
namespace: biological_process
def: "The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:12411483]
is_a: GO:0030974 ! thiamine pyrophosphate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990546
name: mitochondrial tricarboxylic acid transmembrane transport
namespace: biological_process
def: "The process in which a tricarboxylic acid is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw]
is_a: GO:0035674 ! tricarboxylic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990547
name: mitochondrial phosphate ion transmembrane transport
namespace: biological_process
def: "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701]
is_a: GO:0035435 ! phosphate ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990548
name: mitochondrial FAD transmembrane transport
namespace: biological_process
def: "The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:14555654]
is_a: GO:0035350 ! FAD transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990549
name: mitochondrial NAD transmembrane transport
namespace: biological_process
def: "The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:16291748]
is_a: GO:0035352 ! NAD transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990550
name: mitochondrial alpha-ketoglutarate transmembrane transport
namespace: biological_process
alt_id: GO:1990552
def: "The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11013234, PMID:20371607]
synonym: "mitochondrial 2-oxoglutarate transmembrane transport" EXACT []
is_a: GO:0015742 ! alpha-ketoglutarate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990551
name: mitochondrial 2-oxoadipate transmembrane transport
namespace: biological_process
def: "The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11013234]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990553
name: mitochondrial 5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:24296033]
is_a: GO:1902558 ! 5'-adenylyl sulfate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990554
name: mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:24296033]
is_a: GO:1902559 ! 3'-phospho-5'-adenylyl sulfate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990555
name: mitochondrial oxaloacetate transmembrane transport
namespace: biological_process
def: "The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783]
is_a: GO:1902356 ! oxaloacetate(2-) transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990556
name: mitochondrial isopropylmalate transmembrane transport
namespace: biological_process
def: "The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783]
is_a: GO:1902357 ! 2-isopropylmalate(2-) transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990557
name: mitochondrial sulfate transmembrane transport
namespace: biological_process
def: "The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783]
is_a: GO:1902358 ! sulfate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990558
name: mitochondrial malonate(1-) transmembrane transport
namespace: biological_process
def: "The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783]
is_a: GO:1901553 ! malonic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990559
name: mitochondrial coenzyme A transmembrane transport
namespace: biological_process
def: "The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11158296]
is_a: GO:0035349 ! coenzyme A transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990560
name: obsolete DNA methyltransferase binding
namespace: molecular_function
def: "OBSOLETE. Binding to a DNA methyltransferase." [PMID:22880885]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "DNA methyltransferase binding" EXACT []
is_obsolete: true

[Term]
id: GO:1990561
name: obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion starvation
namespace: biological_process
def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of copper ions." [GOC:al, PMID:10593913]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0006357
consider: GO:0035874

[Term]
id: GO:1990562
name: syndecan-syntenin-ALIX complex
namespace: cellular_component
def: "An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery." [GOC:bhm, PMID:22660413]
comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction).
synonym: "exosome complex" BROAD []
is_a: GO:1990563 ! extracellular exosome complex

[Term]
id: GO:1990563
name: extracellular exosome complex
namespace: cellular_component
def: "A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome." [GOC:bhm, PMID:22660413]
comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction).
synonym: "exosome complex" EXACT []
synonym: "extracellular vesicular exosome complex" EXACT [GOC:vesicles]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0070062 ! extracellular exosome

[Term]
id: GO:1990564
name: protein polyufmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain." [PMID:25219498]
is_a: GO:0071569 ! protein ufmylation

[Term]
id: GO:1990565
name: HSP90-CDC37 chaperone complex
namespace: cellular_component
def: "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624]
comment: An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).
is_a: GO:0101031 ! protein folding chaperone complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:1990566
name: I(KACh) inward rectifier potassium channel complex
namespace: cellular_component
def: "An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signaling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits." [GOC:ame, PMID:9765280]
comment: Examples of this are KCNJ3 and KCNJ5 in human (Uniprot symbols P48549 and P48544) in PMID:9765280 inferred from orthology sequence evidence.
synonym: "GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED []
synonym: "Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED []
synonym: "muscarinic potassium channel complex" RELATED []
is_a: GO:1902937 ! inward rectifier potassium channel complex

[Term]
id: GO:1990567
name: DPS complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22." [PMID:24945319]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex

[Term]
id: GO:1990568
name: obsolete MIS18 complex
namespace: cellular_component
def: "OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly." [GOC:bhm, PMID:25036634]
comment: An example of this is MIS18A in human (Q9NYP9) in PMID:25036634 (inferred from physical interaction).
synonym: "MIS18 complex" EXACT []
is_obsolete: true

[Term]
id: GO:1990569
name: UDP-N-acetylglucosamine transmembrane transport
namespace: biological_process
alt_id: GO:0015788
def: "The process in which UDP-N-acetylglucosamine is transported across a membrane." [PMID:10788474]
synonym: "UDP-N-acetylglucosamine transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport

[Term]
id: GO:1990570
name: GDP-mannose transmembrane transport
namespace: biological_process
alt_id: GO:0015784
def: "The process in which GDP-mannose is transported across a membrane." [PMID:9395539]
synonym: "GDP-mannose transport" RELATED []
is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport

[Term]
id: GO:1990571
name: meiotic centromere clustering
namespace: biological_process
def: "The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I." [PMID:10366596, PMID:9009280]
synonym: "centromere clustering during meiosis" EXACT []
synonym: "homologous chromosome movement towards spindle pole in meiosis I prometaphase" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:0098653 ! centromere clustering

[Term]
id: GO:1990572
name: TERT-RMRP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP)." [GOC:bf, GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19701182]
synonym: "telomerase reverse transcriptase:RMRP RNA complex" EXACT [PMID:19701182]
is_a: GO:0031379 ! RNA-directed RNA polymerase complex
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:1990573
name: potassium ion import across plasma membrane
namespace: biological_process
alt_id: GO:0010107
def: "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]
synonym: "potassium import" BROAD []
synonym: "potassium ion import" BROAD []
synonym: "potassium ion uptake" BROAD [GOC:dph, GOC:tb]
is_a: GO:0071805 ! potassium ion transmembrane transport
is_a: GO:0098659 ! inorganic cation import across plasma membrane

[Term]
id: GO:1990574
name: meiotic spindle astral microtubule
namespace: cellular_component
def: "Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [PMID:10366596]
is_a: GO:0000235 ! astral microtubule
relationship: part_of GO:0072687 ! meiotic spindle

[Term]
id: GO:1990575
name: mitochondrial L-ornithine transmembrane transport
namespace: biological_process
alt_id: GO:0000066
def: "The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9237680]
synonym: "mitochondrial ornithine transmembrane transport" BROAD []
synonym: "mitochondrial ornithine transport" RELATED []
is_a: GO:1903352 ! L-ornithine transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:1990576
name: G protein-coupled glucose receptor activity
namespace: molecular_function
def: "Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [PMID:15667320]
synonym: "G-protein coupled glucose receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:1990577
name: C-terminal protein demethylation
namespace: biological_process
def: "The removal of a methyl group from the C-terminal amino acid of a protein." [PMID:11060018]
subset: gocheck_obsoletion_candidate
is_a: GO:0006482 ! protein demethylation

[Term]
id: GO:1990578
name: perinuclear endoplasmic reticulum membrane
namespace: cellular_component
def: "The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus." [PMID:25454947]
synonym: "perinuclear ER membrane" EXACT []
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0097038 ! perinuclear endoplasmic reticulum

[Term]
id: GO:1990579
name: peptidyl-serine trans-autophosphorylation
namespace: biological_process
def: "The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:bf, GOC:PARL, PMID:21317875]
subset: gocheck_obsoletion_candidate
synonym: "serine autophosphorylation in trans" EXACT [PMID:21317875]
synonym: "serine transautophosphorylation" EXACT [PMID:21317875]
is_a: GO:0036289 ! peptidyl-serine autophosphorylation
is_a: GO:0036290 ! protein trans-autophosphorylation

[Term]
id: GO:1990580
name: regulation of cytoplasmic translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975]
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:2000765 ! regulation of cytoplasmic translation
relationship: regulates GO:0002184 ! cytoplasmic translational termination

[Term]
id: GO:1990581
name: obsolete lysosome lysis
namespace: biological_process
def: "OBSOLETE. The rupture of the lysosomal membrane and loss of contents as a result of osmotic change, G-protein-driven disintegration, or unspecified cause." [PMID:24472, PMID:9538255]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "lysosomal lysis" EXACT []
synonym: "lysosome lysis" EXACT []
is_obsolete: true

[Term]
id: GO:1990582
name: obsolete intracellular membrane-bounded organelle binding
namespace: molecular_function
def: "OBSOLETE. The temporary binding of a protein or protein complex to the membrane of an intracellular membrane-bounded organelle." [PMID:16100119, PMID:9538255]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "intracellular membrane-bounded organelle binding" EXACT []
synonym: "intracellular membrane-enclosed organelle binding" EXACT []
is_obsolete: true

[Term]
id: GO:1990583
name: phospholipase D activator activity
namespace: molecular_function
def: "Binds to and increases the activity of the enzyme phospholipase D." [PMID:7972129]
is_a: GO:0016004 ! phospholipase activator activity

[Term]
id: GO:1990584
name: cardiac Troponin complex
namespace: cellular_component
def: "A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction." [GOC:ame, PMID:12840750]
synonym: "cTnC:cTnI:cTnT" RELATED []
is_a: GO:0005861 ! troponin complex

[Term]
id: GO:1990585
name: hydroxyproline O-arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H+ + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP." [PMID:24036508, RHEA:49472]
synonym: "HPAT" EXACT []
xref: EC:2.4.2.58
xref: MetaCyc:RXN-15011
xref: RHEA:49472
is_a: GO:0016763 ! pentosyltransferase activity

[Term]
id: GO:1990586
name: divisome complex
namespace: cellular_component
def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells." [GOC:bhm, PMID:15165235, PMID:21784946]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030428 ! cell septum

[Term]
id: GO:1990587
name: FtsQBL complex
namespace: cellular_component
def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ." [GOC:bhm, PMID:15165235, PMID:21784946]
comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction).
synonym: "FtsB-FtsL-FtsQ complex" EXACT []
is_a: GO:1990586 ! divisome complex

[Term]
id: GO:1990588
name: FtsBL complex
namespace: cellular_component
def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL." [GOC:bhm, PMID:15165235, PMID:21784946]
comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction).
synonym: "FtsB-FtsL complex" EXACT []
is_a: GO:1990586 ! divisome complex
relationship: part_of GO:0005829 ! cytosol
relationship: part_of GO:1990587 ! FtsQBL complex

[Term]
id: GO:1990589
name: ATF4-CREB1 transcription factor complex
namespace: cellular_component
def: "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, PMID:12871976]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990590
name: ATF1-ATF4 transcription factor complex
namespace: cellular_component
def: "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway." [GOC:bhm, PMID:12871976]
comment: An example of this is ATF1in human (P18846) in PMID:12871976 (inferred from physical interaction).
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990591
name: asparagine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of asparagine into the vacuole across the vacuolar membrane." [PMID:20388511]
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:1903713 ! asparagine transmembrane transport

[Term]
id: GO:1990592
name: protein K69-linked ufmylation
namespace: biological_process
def: "A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]
is_a: GO:1990564 ! protein polyufmylation

[Term]
id: GO:1990593
name: nascent polypeptide-associated complex binding
namespace: molecular_function
def: "Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:25487825]
synonym: "NAC binding" EXACT []
synonym: "NACA binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding

[Term]
id: GO:1990594
name: L-altrarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [PMID:17649980]
synonym: "L-talarate dehydratase activity" EXACT []
xref: RHEA:44028
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:1990595
name: mast cell secretagogue receptor activity
namespace: molecular_function
def: "Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells." [GOC:sp, PMID:25517090]
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:1990596
name: obsolete histone H3-K4 deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone." [PMID:20299449]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:1990162

[Term]
id: GO:1990597
name: AIP1-IRE1 complex
namespace: cellular_component
def: "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein)." [GOC:bf, GOC:PARL, PMID:18281285]
synonym: "AIP1-ERN1 complex" RELATED [HGNC:3449]
synonym: "IRE1-DAB2IP complex" EXACT [GOC:bf]
synonym: "IRE1alpha-AIP1 complex" NARROW [GOC:bf]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990599
name: 3' overhang single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555]
is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity

[Term]
id: GO:1990600
name: single-stranded DNA endodeoxyribonuclease activator activity
namespace: molecular_function
def: "Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity." [PMID:25203555]
is_a: GO:0140656 ! endodeoxyribonuclease activator activity

[Term]
id: GO:1990601
name: 5' overhang single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555]
is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity

[Term]
id: GO:1990602
name: obsolete importin alpha-subunit nuclear import complex
namespace: cellular_component
def: "OBSOLETE. A trimeric protein complex which functions to transport the importin alpha-subunit into the nucleus through the nuclear pore to facilitate another round of mRNP incorporation and regulation. In Drosophila it consists of Cdm (Imp13), Mago and Tsu (Y14)." [GOC:bhm, PMID:20122403]
comment: The reason for obsoletion is that these terms include the substrate of the reaction.
synonym: "Cdm-Mago-Tsu complex" NARROW []
synonym: "Importin13-Mago-Tsu complex" NARROW []
is_obsolete: true

[Term]
id: GO:1990603
name: dark adaptation
namespace: biological_process
def: "The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light." [GOC:hjd, https://www.ncbi.nlm.nih.gov/books/NBK11525/, PMID:11420957, PMID:35268448]
comment: The proteins RGS9-1 and Gb5L localize to the rod inner segment during dark adaptation, but to the rod outer segment during light adaptation. PMID:23555598
is_a: GO:0071485 ! cellular response to absence of light

[Term]
id: GO:1990604
name: IRE1-TRAF2-ASK1 complex
namespace: cellular_component
def: "A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K)." [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344]
synonym: "ERN1-TRAF2-ASK1 complex" RELATED [HGNC:3449]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:1990605
name: GU repeat RNA binding
namespace: molecular_function
def: "Binding to an RNA molecule containing GU repeats." [PMID:20081200]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:1990606
name: membrane scission GTPase motor activity
namespace: molecular_function
def: "Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis." [PMID:11242086, PMID:23530241, PMID:24515348]
is_a: GO:0061791 ! GTPase motor activity

[Term]
id: GO:1990607
name: obsolete detection of stimulus involved in cytokinesis after mitosis checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether cytokinesis has correctly completed, is received and converted into a molecular signal, contributing to a cytokinesis after mitosis checkpoint." [GOC:mtg_cell_cycle, GOC:vw, PMID:1234]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990608
name: mitotic spindle pole body localization
namespace: biological_process
alt_id: GO:0070632
alt_id: GO:0071789
def: "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location." [PMID:24963130]
synonym: "establishment and maintenance of spindle pole body localization" EXACT []
synonym: "establishment of spindle pole body localisation" NARROW [GOC:mah]
synonym: "establishment of spindle pole body localization" NARROW []
synonym: "mitotic spindle pole body localization to nuclear envelope" NARROW []
synonym: "spindle pole body docking" NARROW [GOC:vw]
synonym: "spindle pole body localisation in nuclear envelope" NARROW [GOC:mah]
synonym: "spindle pole body localization in nuclear envelope" NARROW []
synonym: "spindle pole body localization to nuclear envelope" NARROW []
synonym: "spindle pole body positioning" NARROW [GOC:vw]
is_a: GO:0070631 ! spindle pole body localization
is_a: GO:1903047 ! mitotic cell cycle process

[Term]
id: GO:1990609
name: glutamate-cysteine ligase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of glutamate-cysteine ligase." [PMID:8103521]
is_a: GO:0055103 ! ligase regulator activity

[Term]
id: GO:1990610
name: acetolactate synthase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of acetolactate synthase." [PMID:8972574]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:1990611
name: regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445]
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
is_a: GO:1990497 ! regulation of cytoplasmic translation in response to stress

[Term]
id: GO:1990612
name: Sad1-Kms1 LINC complex
namespace: cellular_component
def: "A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair." [GOC:vw, PMID:24943839, PMID:24947240]
is_a: GO:0034993 ! meiotic nuclear membrane microtubule tethering complex

[Term]
id: GO:1990615
name: Kelch-containing formin regulatory complex
namespace: cellular_component
def: "A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p." [PMID:24828508]
synonym: "Bud14-Kel1-Kel2 complex" NARROW []
synonym: "KFRC complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990616
name: magnesium ion export from mitochondrion
namespace: biological_process
def: "The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore." [PMID:25585246]
synonym: "magnesium ion efflux from mitochondrion" EXACT []
is_a: GO:0045016 ! mitochondrial magnesium ion transmembrane transport
is_a: GO:0170037 ! export from the mitochondrion

[Term]
id: GO:1990617
name: CHOP-ATF4 complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits." [GOC:bf, GOC:PARL, PMID:18940792]
synonym: "ATF4-CHOP heterodimer" EXACT [PMID:18940792]
synonym: "CHOP-ATF4 heterodimer" EXACT [PMID:18940792]
synonym: "CHOP-CREB-2 complex" EXACT [PMID:11478948]
synonym: "CHOP/ATF4 complex" EXACT [PMID:18940792]
synonym: "GADD153-ATF4 complex" EXACT [GOC:bf]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990618
name: obsolete ANPR-A:ANP complex
namespace: cellular_component
def: "OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis." [GOC:ame, PMID:15117952]
comment: An example of this is [ANPR-A:ANP] in [rat] (P18910:P01161-PRO_0000391785) in PMID:15117952 (inferred from direct assay).
synonym: "ANPR-A:ANP complex" EXACT []
is_obsolete: true

[Term]
id: GO:1990619
name: obsolete histone H3-K9 deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone." [PMID:25002536]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990620
name: ANPR-A receptor complex
namespace: cellular_component
def: "A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure." [GOC:ame, PMID:15117952]
comment: An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
synonym: "NPR1 receptor complex" RELATED []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:1990621
name: ESCRT IV complex
namespace: cellular_component
def: "An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1." [GOC:bhm, GOC:ha, PMID:20653365, PMID:20696398, PMID:21925211, PMID:24456136, PMID:25164817, PMID:26775243]
synonym: "ESCRT-IV" EXACT []
synonym: "vacuolar protein sorting-associated complex" RELATED []
synonym: "Vps4 complex" RELATED []
synonym: "Vps4-Vta1 complex" NARROW []
synonym: "VPS4A-VPS4B" NARROW []
synonym: "VPS4A/B complex" NARROW []
synonym: "Vta1-Vps4 complex" RELATED []
is_a: GO:0036452 ! ESCRT complex
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1904949 ! ATPase complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:1990622
name: CHOP-ATF3 complex
namespace: cellular_component
def: "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits." [GOC:bf, GOC:PARL, PMID:8622660]
synonym: "ATF3-CHOP complex" EXACT [GOC:bf]
synonym: "CHOP-ATF3 heterodimer" EXACT [GOC:bf]
synonym: "CHOP-ATF3 heterodimeric complex" EXACT [GOC:bf]
synonym: "GADD153-ATF3 complex" EXACT [GOC:bf]
is_a: GO:0005667 ! transcription regulator complex
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:1990623
name: Herring body
namespace: cellular_component
def: "The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively." [ISBN:0199652473, Wikipedia:Herring_bodies]
synonym: "neurosecretory body" EXACT []
is_a: GO:0043679 ! axon terminus

[Term]
id: GO:1990624
name: guanyl nucleotide exchange factor inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor." [GOC:vw, PMID:25635048]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:1990625
name: negative regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation
is_a: GO:1990611 ! regulation of cytoplasmic translational initiation in response to stress

[Term]
id: GO:1990626
name: mitochondrial outer membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane." [GOC:vw, PMID:21385840]
synonym: "mitochondrion outer membrane fusion" EXACT []
is_a: GO:0007008 ! outer mitochondrial membrane organization
relationship: part_of GO:0008053 ! mitochondrial fusion

[Term]
id: GO:1990627
name: mitochondrial inner membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two mitochondrial inner membranes to form a single membrane." [GOC:vw, PMID:17055438]
synonym: "mitochondrion inner membrane fusion" EXACT []
is_a: GO:0007007 ! inner mitochondrial membrane organization
relationship: part_of GO:0008053 ! mitochondrial fusion

[Term]
id: GO:1990628
name: obsolete Sigma-E factor negative regulation complex
namespace: cellular_component
def: "OBSOLETE. A protein complex consisting of RseA, RseB and RpoE. It form the inactive form of the sigma-E transcription factor. In response to stress, outer membrane proteins accumulate in the periplasm and activate cleavage of RseA periplasmic domain by DegS, triggering a proteolytic cascade that frees sigma-E to activate gene expression. RseB binding to RseA prevents activated DegS from cleaving RseA. Sigma-E-mediated envelope stress response is the major pathway to ensure homeostasis in the envelope compartment of the cell." [GOC:bhm, PMID:20190044]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "RseA-RseB-RpoE complex" RELATED []
synonym: "Sigma-E factor negative regulation complex" EXACT []
is_obsolete: true

[Term]
id: GO:1990629
name: phospholamban complex
namespace: cellular_component
def: "A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels." [GOC:ame, PMID:16043693]
comment: An example of this is PLN in human (UniProt symbol P26678) in PMID:16043693 (inferred from direct assay).
synonym: "cardiac phospholamban complex" EXACT []
synonym: "cardiac PLB complex" RELATED []
synonym: "cardiac PLN complex" RELATED []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:1990630
name: IRE1-RACK1-PP2A complex
namespace: cellular_component
def: "A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A." [GOC:bf, GOC:PARL, PMID:20103773]
synonym: "ERN1-RACK1-PP2A complex" RELATED [HGNC:3449]
synonym: "IRE1alpha-RACK1-PP2A complex" NARROW [GOC:bf, PMID:20103773]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990631
name: ErbB-4 class receptor binding
namespace: molecular_function
def: "Binding to the protein-tyrosine kinase receptor ErbB-4/HER4." [GOC:sl, PMID:18523588]
synonym: "HER4 receptor binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:1990632
name: branching involved in submandibular gland morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the submandibular gland is generated and organized." [PMID:15063181, PMID:20890964]
synonym: "submandibular gland branching morphogenesis" EXACT [PMID:20890964]
synonym: "submandibular gland ductal branching" EXACT [PMID:20890964]
is_a: GO:0060445 ! branching involved in salivary gland morphogenesis

[Term]
id: GO:1990633
name: mutator focus
namespace: cellular_component
def: "A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules." [GOC:kmv, PMID:22713602, PMID:25635455]
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
relationship: part_of GO:0048471 ! perinuclear region of cytoplasm

[Term]
id: GO:1990634
name: protein phosphatase 5 binding
namespace: molecular_function
def: "Binding to protein phosphatase 5." [PMID:8943293]
synonym: "protein phosphatase T binding" EXACT []
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:1990635
name: proximal dendrite
namespace: cellular_component
def: "The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:16899232]
is_a: GO:0030425 ! dendrite

[Term]
id: GO:1990636
name: reproductive senescence
namespace: biological_process
def: "A life cycle stage during which the reproductive capacity and fitness of an organism declines." [PMID:24914937, PMID:25523082, PMID:27353257]
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
subset: gocheck_do_not_annotate
synonym: "ovarian senescence" NARROW []
is_a: GO:0044848 ! biological phase

[Term]
id: GO:1990637
name: response to prolactin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation." [PMID:7760850]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:1990638
name: response to granulocyte colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469]
synonym: "response to G-CSF" EXACT []
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:1990639
name: obsolete inositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4,5-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [PMID:11348594]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "inositol-3,4,5-trisphosphate 5-phosphatase activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990640
name: inositol-2,4,5-triphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate." [PMID:15316017]
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:1990641
name: response to iron ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion." [PMID:16208485]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:1990642
name: obsolete response to castration
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a castration stimulus, deprivation of gonads." [PMID:11255226]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to castration" EXACT []
is_obsolete: true

[Term]
id: GO:1990643
name: cellular response to granulocyte colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:1990638 ! response to granulocyte colony-stimulating factor

[Term]
id: GO:1990644
name: microtubule site clamp
namespace: molecular_function
def: "The binding activity of a molecule that attaches the spindle microtubules to the kinetochore." [PMID:20723757]
is_a: GO:0030674 ! protein-macromolecule adaptor activity

[Term]
id: GO:1990645
name: obsolete phosphorylase dephosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of phosphorylases by removal of phosphate groups." [PMID:8602837]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "phosphorylase dephosphorylation" EXACT []
is_obsolete: true

[Term]
id: GO:1990646
name: cellular response to prolactin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus." [PMID:7760850]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990637 ! response to prolactin

[Term]
id: GO:1990647
name: C/EBP complex
namespace: cellular_component
def: "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121]
comment: An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay).
synonym: "C/EBP homodimer complex" EXACT []
synonym: "C/EBP transcription factor complex" EXACT []
synonym: "C/EBPalpha complex" NARROW []
synonym: "C/EBPalpha homodimer complex" NARROW []
synonym: "C/EBPbeta complex" NARROW []
synonym: "C/EBPbeta homodimer complex" NARROW []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990648
name: inositol-4,5,6-triphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:1990649
name: inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:1990650
name: inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:1990651
name: inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity

[Term]
id: GO:1990652
name: obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [PMID:23695302]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT []
is_obsolete: true

[Term]
id: GO:1990653
name: obsolete monounsaturated fatty acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a monounsaturated fatty acid. A monounsaturated fatty acid has one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded, as opposed to polyunsaturated fatty acids." [GOC:hjd, PMID:16443825]
comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast.
is_obsolete: true

[Term]
id: GO:1990654
name: sebum secreting cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum." [GOC:hjd, PMID:16901790, PMID:18474083]
synonym: "sebocyte proliferation" RELATED [GOC:dph]
is_a: GO:0008283 ! cell population proliferation

[Term]
id: GO:1990655
name: 4 iron, 3 sulfur cluster binding
namespace: molecular_function
def: "Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria." [GOC:am, PMID:23267108]
synonym: "4Fe-3S cluster binding" RELATED []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:1990656
name: t-SNARE clustering
namespace: biological_process
def: "The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies." [PMID:22528485]
is_a: GO:0072657 ! protein localization to membrane

[Term]
id: GO:1990657
name: iNOS-S100A8/A9 complex
namespace: cellular_component
def: "A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine." [GOC:bhm, PMID:25417112]
comment: An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay).
is_a: GO:1903958 ! nitric-oxide synthase complex
is_a: GO:1990658 ! transnitrosylase complex

[Term]
id: GO:1990658
name: transnitrosylase complex
namespace: cellular_component
def: "A transferase complex which is capable of transferring nitrogenous groups from one component to another." [GOC:bhm, PMID:25417112]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
synonym: "transferase complex, transferring nitrogenous groups" EXACT []
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:1990659
name: obsolete sequestering of manganese ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining manganese ions such that they are separated from other components of a biological system." [GOC:bhm, PMID:25417112]
comment: The reason for obsoletion is that this represents a molecular function, not a biological process.
synonym: "manganese ion retention" EXACT []
synonym: "manganese ion sequestering" EXACT []
synonym: "manganese ion sequestration" EXACT []
synonym: "manganese ion storage" EXACT []
synonym: "retention of manganese ion" EXACT []
synonym: "sequestration of manganese ion" EXACT []
synonym: "storage of manganese ion" EXACT []
is_obsolete: true
consider: GO:0140487

[Term]
id: GO:1990660
name: calprotectin complex
namespace: cellular_component
def: "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
synonym: "calprotectin heterodimer" NARROW []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990661
name: S100A8 complex
namespace: cellular_component
def: "A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4)." [GOC:bhm, PMID:25417112]
comment: An example of this is S100A8 in human (UniProt symbol P27005) in PMID:25417112 (inferred from direct assay).
synonym: "S100A8 homodimer" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990662
name: S100A9 complex
namespace: cellular_component
def: "A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility." [GOC:bhm, PMID:15642721]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay).
synonym: "S100A9 homodimer" EXACT []
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:1990663
name: dihydroorotate dehydrogenase (fumarate) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [PMID:1409592, RHEA:30059]
xref: EC:1.3.98.1
xref: RHEA:30059
is_a: GO:0004152 ! dihydroorotate dehydrogenase activity

[Term]
id: GO:1990664
name: Nkx-2.5 complex
namespace: cellular_component
def: "A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes." [GOC:ame, PMID:22849347]
comment: An example of this is Nkx-2.5 in human (UniProt symbol P52952) in PMID:22849347 (inferred from direct assay).
synonym: "Nkx-2.5 homodimer complex" NARROW []
synonym: "NKX.2-5 homodimer complex" RELATED []
synonym: "NKX2.5 complex" RELATED []
synonym: "NKX2E homodimer complex" RELATED []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990665
name: AnxA2-p11 complex
namespace: cellular_component
def: "A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10)." [GOC:bf, GOC:BHF, GOC:nc, PMID:18799458, PMID:23483454]
synonym: "(A2.p11)2 complex" EXACT [PMID:23483454]
synonym: "(p11)2.(AnxA2)2 complex" EXACT [PMID:18799458]
synonym: "Annexin A2 tetramer" RELATED [PMID:23483454]
synonym: "Annexin A2-p11 complex" EXACT [GOC:bf]
synonym: "AnxA2.p11 complex" EXACT [PMID:18799458]
synonym: "AnxA2:S100A10 heterotetramer" EXACT [PMID:23483454]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990666
name: PCSK9-LDLR complex
namespace: cellular_component
def: "A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway." [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079]
synonym: "PCSK9.LDLR complex" EXACT [PMID:18799458]
synonym: "PCSK9/LDL-R complex" EXACT [PMID:24440079]
synonym: "PCSK9:EGF-A complex" RELATED [PMID:18250299]
synonym: "PCSK9:low-density lipoprotein receptor complex" EXACT [GOC:bf]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990667
name: PCSK9-AnxA2 complex
namespace: cellular_component
def: "A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2)." [GOC:BHF, GOC:nc, PMID:22848640]
synonym: "PCSK9-Annexin A2 complex" EXACT [GOC:bf]
synonym: "PCSK9.AnxA2 complex" EXACT [PMID:18799458]
synonym: "PCSK9:ANXA2 complex" EXACT [GOC:bf]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990668
name: vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
synonym: "vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane" EXACT []
synonym: "vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT []
synonym: "vesicle fusion with ERGIC membrane" EXACT []
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:1990669
name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane" EXACT []
synonym: "ER-Golgi intermediate compartment derived vesicle fusion with ER membrane" EXACT []
is_a: GO:0048279 ! vesicle fusion with endoplasmic reticulum
relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

[Term]
id: GO:1990670
name: vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:1990671
name: vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus

[Term]
id: GO:1990672
name: medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport

[Term]
id: GO:1990673
name: obsolete intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: cellular_component
def: "OBSOLETE. The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
is_obsolete: true
replaced_by: GO:0033116

[Term]
id: GO:1990674
name: Golgi cis cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "cis-Golgi cisterna membrane" EXACT []
synonym: "Golgi apparatus cis cisterna membrane" EXACT []
is_a: GO:0032580 ! Golgi cisterna membrane
relationship: part_of GO:0000137 ! Golgi cis cisterna

[Term]
id: GO:1990675
name: Golgi medial cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "Golgi apparatus medial cisterna membrane" EXACT []
synonym: "medial-Golgi cisterna membrane" EXACT []
is_a: GO:0032580 ! Golgi cisterna membrane
relationship: part_of GO:0005797 ! Golgi medial cisterna

[Term]
id: GO:1990676
name: Golgi trans cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "trans-Golgi cisterna membrane" EXACT []
is_a: GO:0032580 ! Golgi cisterna membrane
relationship: part_of GO:0000138 ! Golgi trans cisterna

[Term]
id: GO:1990677
name: mitochondrial inner membrane assembly complex
namespace: cellular_component
def: "A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion." [GOC:bhm, PMID:24942160]
comment: An example of this is INA22 in Saccharomyces cerevisiae (P40576) in PMID:24942160 (inferred from direct assay/mutant phenotype/etc.).
synonym: "INAC complex" EXACT []
synonym: "inner membrane assembly complex" BROAD []
synonym: "mitochondrion inner membrane assembly complex" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex

[Term]
id: GO:1990678
name: obsolete histone H4-K16 deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone." [PMID:17446861]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990679
name: obsolete histone H4-K12 deacetylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone." [PMID:17446861]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990680
name: response to melanocyte-stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates." [PMID:17036007]
synonym: "response to MSH" EXACT []
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:1990682
name: CSF1-CSF1R complex
namespace: cellular_component
def: "A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand." [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797]
synonym: "CSF1:C-FMS complex" EXACT [HGNC:2432, HGNC:2433]
synonym: "M-CSF:C-FMS complex" RELATED [GOC:nc]
synonym: "M-CSF:CSF1R complex" RELATED [HGNC:2432, HGNC:2433]
synonym: "M-CSF:FMS complex" EXACT [PMID:19017797]
synonym: "macrophage colony-stimulating factor:receptor complex" EXACT [GOC:bf]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990683
name: DNA double-strand break attachment to nuclear envelope
namespace: biological_process
def: "A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs." [PMID:24943839]
is_a: GO:0097240 ! chromosome attachment to the nuclear envelope

[Term]
id: GO:1990684
name: protein-lipid-RNA complex
namespace: cellular_component
def: "A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:22028337, PMID:23559634]
comment: Examples of protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle' or GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs.
synonym: "miRNA-lipoprotein complex" RELATED []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990685
name: HDL-containing protein-lipid-RNA complex
namespace: cellular_component
def: "A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:23559634]
comment: Examples of HDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoproteins (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle', which describes complexes of proteins and lipids only, without RNAs.
is_a: GO:1990684 ! protein-lipid-RNA complex

[Term]
id: GO:1990686
name: LDL-containing protein-lipid-RNA complex
namespace: cellular_component
def: "A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:23559634]
comment: Examples of LDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs.
is_a: GO:1990684 ! protein-lipid-RNA complex

[Term]
id: GO:1990687
name: endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT []
synonym: "ER-derived vesicle fusion with ERGIC membrane" EXACT []
is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport

[Term]
id: GO:1990688
name: Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "Golgi vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT []
synonym: "Golgi vesicle fusion with ERGIC membrane" EXACT []
is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

[Term]
id: GO:1990689
name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
synonym: "ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
synonym: "ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane" EXACT []
synonym: "ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
synonym: "ERGIC-derived vesicle fusion with Golgi cis cisterna membrane" EXACT []
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
is_a: GO:1990670 ! vesicle fusion with Golgi cis cisterna membrane
relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport

[Term]
id: GO:1990690
name: Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "Golgi apparatus medial cisterna-derived vesicle fusion with Golgi apparatus cis cisterna membrane" EXACT []
synonym: "medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi

[Term]
id: GO:1990691
name: cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT []
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport

[Term]
id: GO:1990692
name: trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT []
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi

[Term]
id: GO:1990693
name: obsolete intrinsic component of Golgi cis cisterna membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic component of cis-Golgi cisterna membrane" EXACT []
is_obsolete: true
replaced_by: GO:1990674

[Term]
id: GO:1990694
name: obsolete intrinsic component of Golgi medial cisterna membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic component of medial-Golgi cisterna membrane" EXACT []
is_obsolete: true
replaced_by: GO:1990675

[Term]
id: GO:1990695
name: obsolete intrinsic component of Golgi trans cisterna membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "intrinsic component of trans-Golgi cisterna membrane" EXACT []
is_obsolete: true
replaced_by: GO:1990676

[Term]
id: GO:1990696
name: USH2 complex
namespace: cellular_component
def: "A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7." [GOC:krc, PMID:25406310]
synonym: "USH2 quaternary protein complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990697
name: protein depalmitoleylation
namespace: biological_process
def: "The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein." [PMID:25731175]
subset: gocheck_obsoletion_candidate
is_a: GO:0035601 ! protein deacylation
is_a: GO:0042159 ! lipoprotein catabolic process

[Term]
id: GO:1990698
name: palmitoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175]
comment: Note that this term should not be confused with 'palmitoyltransferase activity ; GO:0016409'.
is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups

[Term]
id: GO:1990699
name: palmitoleyl hydrolase activity
namespace: molecular_function
def: "Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate." [PMID:25731175]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:1990700
name: nucleolar chromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178]
synonym: "establishment or maintenance of nucleolar chromatin architecture" EXACT []
synonym: "nucleolar chromatin organisation" EXACT []
is_a: GO:0006325 ! chromatin organization
relationship: part_of GO:0007000 ! nucleolus organization

[Term]
id: GO:1990701
name: obsolete integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: cellular_component
def: "OBSOLETE. The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
synonym: "integral component of ER-Golgi intermediate compartment membrane" EXACT []
synonym: "integral component of ERGIC membrane" EXACT []
is_obsolete: true
replaced_by: GO:0033116

[Term]
id: GO:1990702
name: obsolete integral component of Golgi cis cisterna membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral component of cis-Golgi cisterna membrane" EXACT []
is_obsolete: true
replaced_by: GO:1990674

[Term]
id: GO:1990703
name: obsolete integral component of Golgi medial cisterna membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral component of medial-Golgi cisterna membrane" EXACT []
is_obsolete: true
replaced_by: GO:1990675

[Term]
id: GO:1990704
name: obsolete integral component of Golgi trans cisterna membrane
namespace: cellular_component
def: "OBSOLETE. The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
synonym: "integral component of trans-Golgi cisterna membrane" EXACT []
is_obsolete: true
replaced_by: GO:1990676

[Term]
id: GO:1990705
name: cholangiocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010]
synonym: "hepatoblast proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:1990706
name: MAD1 complex
namespace: cellular_component
def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C)." [GOC:bhm, intAct:EBI-10691224, PMID:22493223, PMID:22898774]
synonym: "MAD1 homodimer" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990708
name: conditioned place preference
namespace: biological_process
def: "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug." [PMID:21549821]
is_a: GO:0008306 ! associative learning

[Term]
id: GO:1990709
name: presynaptic active zone organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone." [GOC:pr, PMID:16865347, PMID:17068967]
synonym: "presynaptic active zone organisation" EXACT []
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:1990710
name: MutS complex
namespace: cellular_component
def: "A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations." [GOC:bhm, PMID:21666597]
comment: An example of this is MutS in E. coli (UniProt symbol P23909) in PMID:21666597 (inferred from physical interaction).
synonym: "MutS mismatch repair complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:1990391 ! DNA repair complex

[Term]
id: GO:1990711
name: beta-catenin-ICAT complex
namespace: cellular_component
def: "Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex." [GOC:bhm, PMID:12408824]
comment: An example of this is Catenin beta-1 in human (UniProt symbol P35222) in PMID:12408824 (inferred from physical interaction).
synonym: "CTNNB1-CTNNBIP1 complex" EXACT []
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:1990712
name: HFE-transferrin receptor complex
namespace: cellular_component
def: "A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription." [GOC:BHF, GOC:kom, PMID:25147378]
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:1990713
name: survivin complex
namespace: cellular_component
def: "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC)." [GOC:bhm, PMID:10949038]
comment: An example of this is BIRC5 in human (UniProt symbol O15392) in PMID:10949038 (inferred from physical interaction).
synonym: "Baculoviral IAP repeat-containing protein 5 complex" EXACT []
synonym: "survivin homodimer complex" NARROW []
is_a: GO:0140513 ! nuclear protein-containing complex

[Term]
id: GO:1990714
name: hydroxyproline O-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone." [PMID:25600942]
synonym: "HPGT" EXACT []
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:1990715
name: mRNA CDS binding
namespace: molecular_function
def: "Binding to an mRNA molecule coding sequence (CDS)." [GOC:kmv, PMID:25805859, SO:0000316]
synonym: "mRNA coding region binding" EXACT []
synonym: "mRNA coding sequence binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:1990716
name: axonemal central apparatus
namespace: cellular_component
def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:1990717
name: axonemal central bridge
namespace: cellular_component
def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:1990716 ! axonemal central apparatus

[Term]
id: GO:1990718
name: axonemal central pair projection
namespace: cellular_component
def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:1990716 ! axonemal central apparatus

[Term]
id: GO:1990719
name: C1 axonemal microtubule
namespace: cellular_component
def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136]
synonym: "C1 tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097540 ! axonemal central pair

[Term]
id: GO:1990720
name: C2 axonemal microtubule
namespace: cellular_component
def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136]
synonym: "C2 tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097540 ! axonemal central pair

[Term]
id: GO:1990721
name: obsolete prostatic acid phosphatase complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP." [GOC:bhm, PMID:12525165]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "ACPP homodimer complex" NARROW []
synonym: "PAP complex" EXACT []
synonym: "prostatic acid phosphatase complex" EXACT []
is_obsolete: true

[Term]
id: GO:1990722
name: DAPK1-calmodulin complex
namespace: cellular_component
def: "A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding." [GOC:bhm, PMID:20103772]
synonym: "death-associated protein kinase 1 - calmodulin complex" EXACT []
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:1990723
name: cytoplasmic periphery of the nuclear pore complex
namespace: cellular_component
def: "Cytoplasm situated in close proximity to a nuclear pore complex." [PMID:9398662]
synonym: "associated with the nuclear pore" RELATED [GOC:mah]
is_a: GO:0048471 ! perinuclear region of cytoplasm

[Term]
id: GO:1990724
name: galectin complex
namespace: cellular_component
def: "A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes." [GOC:bhm, PMID:15476813, PMID:18777589, PMID:8262940]
comment: An example of this is Galectin-1 in human (P09382) in PMID:15476813 (inferred from physical interaction).
synonym: "galectin-1 complex" NARROW []
synonym: "galectin-2 complex" NARROW []
is_a: GO:0098635 ! protein complex involved in cell-cell adhesion

[Term]
id: GO:1990725
name: cord factor receptor activity
namespace: molecular_function
def: "Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, PMID:23602766]
synonym: "TMD receptor activity" EXACT []
synonym: "trehalose 6,6'-dimycolate receptor activity" EXACT []
xref: Wikipedia:Cord_factor
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:1990726
name: Lsm1-7-Pat1 complex
namespace: cellular_component
def: "A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]
is_a: GO:0120114 ! Sm-like protein family complex

[Term]
id: GO:1990727
name: tubulin folding cofactor complex
namespace: cellular_component
def: "A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur." [GOC:vw, PMID:12445400]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990728
name: mitotic spindle assembly checkpoint MAD1-MAD2 complex
namespace: cellular_component
def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex." [GOC:bhm, PMID:12006501, PMID:22898774]
comment: An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
synonym: "MAD1-MAD2 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:1990730
name: VCP-NSFL1C complex
namespace: cellular_component
def: "A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97." [GOC:bf, GOC:PARL, PMID:9214505]
synonym: "p97-p47 complex" EXACT [GOC:bf, PMID:12847084]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:1990731
name: obsolete UV-damage excision repair, DNA incision
namespace: biological_process
def: "OBSOLETE. A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [PMID:10704216]
comment: This term was obsoleted because it represents a molecular function.
synonym: "alternative excision repair, DNA incision" RELATED [PMID:10704216]
synonym: "DNA incision involved in AER" RELATED [PMID:10704216]
synonym: "DNA incision involved in alternative excision repair" RELATED [PMID:10704216]
synonym: "DNA incision involved in UV-damage excision repair" EXACT []
synonym: "DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT []
synonym: "DNA incision involved in UVDE-dependent excision repair" EXACT []
synonym: "DNA incision involved in UVER" EXACT []
synonym: "nucleic acid cleavage involved in UV-damage excision repair" EXACT []
synonym: "UV-damaged DNA endonuclease-dependent excision repair, DNA incision" EXACT []
synonym: "UVDE-dependent excision repair, DNA incision" EXACT []
is_obsolete: true
replaced_by: GO:0070914

[Term]
id: GO:1990732
name: pyrenoid
namespace: cellular_component
def: "A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation." [GOC:cjm, GOC:pr, PMID:23345319, Wikipedia:Pyrenoid]
xref: Wikipedia:Pyrenoid
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:1990733
name: titin-telethonin complex
namespace: cellular_component
def: "A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils." [GOC:ame, PMID:16407954]
comment: An example of this are TTN and TCAP in human (UniProt symbols Q8WZ42 and O15273 respectively) in PMID:16407954 (inferred from direct assay).
synonym: "Titin-Tcap complex" RELATED []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0030018 ! Z disc

[Term]
id: GO:1990734
name: astral microtubule anchoring at mitotic spindle pole body
namespace: biological_process
def: "Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:15004232]
is_a: GO:0034631 ! microtubule anchoring at spindle pole body

[Term]
id: GO:1990735
name: gamma-tubulin complex localization to mitotic spindle pole body
namespace: biological_process
def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body." [GOC:dos, GOC:mah, PMID:11080156]
synonym: "establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body" EXACT []
synonym: "gamma-tubulin complex localisation to mitotic spindle pole body" EXACT []
synonym: "gamma-tubulin complex localization to mitotic SPB" EXACT []
is_a: GO:0033566 ! gamma-tubulin complex localization

[Term]
id: GO:1990736
name: regulation of vascular associated smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell." [PMID:20826763]
synonym: "regulation of vascular smooth muscle cell membrane depolarization" EXACT []
is_a: GO:0051899 ! membrane depolarization

[Term]
id: GO:1990737
name: response to manganese-induced endoplasmic reticulum stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus." [GOC:bf, GOC:PARL, PMID:23934647]
synonym: "manganese-induced ER stress response" EXACT [GOC:bf]
synonym: "response to manganese-induced ER stress" EXACT [GOC:bf]
synonym: "response to Mn-induced ER stress" EXACT [PMID:23934647]
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0062197 ! cellular response to chemical stress
is_a: GO:0071287 ! cellular response to manganese ion

[Term]
id: GO:1990738
name: pseudouridine 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate." [EC:3.1.3.96, PMID:20722631]
xref: EC:3.1.3.96
xref: RHEA:10944
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:1990739
name: granulosa cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge." [PMID:22383759]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:1990740
name: obsolete non-selective anion channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the non-selective, energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions]
comment: This term was made obsolete because it was added in error.
synonym: "nonselective anion channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990741
name: obsolete non-selective cation channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the non-selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions]
comment: This term was made obsolete because it was added in error.
synonym: "nonselective cation channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:1990742
name: microvesicle
namespace: cellular_component
def: "An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm." [GOC:vesicles, PMID:22418571, PMID:24009894, Wikipedia:Microvesicles]
synonym: "ectosome" EXACT [PMID:25683921]
synonym: "extracellular microvesicle" EXACT []
synonym: "shedding vesicle" BROAD []
is_a: GO:1903561 ! extracellular vesicle

[Term]
id: GO:1990743
name: protein sialylation
namespace: biological_process
def: "A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein." [PMID:21930713]
subset: gocheck_obsoletion_candidate
is_a: GO:0036211 ! protein modification process
is_a: GO:0097503 ! sialylation

[Term]
id: GO:1990745
name: EARP complex
namespace: cellular_component
def: "A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0055037 ! recycling endosome

[Term]
id: GO:1990747
name: pancreatic trypsinogen secretion
namespace: biological_process
def: "The regulated release of trypsinogen from the cells of the exocrine pancreas." [PMID:12771515]
synonym: "pancreatic trypsinogen release" EXACT []
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:1990748
name: cellular detoxification
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]
is_a: GO:0009987 ! cellular process
is_a: GO:0098754 ! detoxification
relationship: part_of GO:0097237 ! cellular response to toxic substance

[Term]
id: GO:1990749
name: polynucleotide adenylyltransferase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme polynucleotide adenylyltransferase." [GOC:kmv, PMID:19460348]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:1990750
name: obsolete axon shaft
namespace: cellular_component
def: "OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites." [PMID:11264310, PMID:24312009]
comment: This term was made obsolete because it was added in error.
synonym: "axonal shaft" EXACT []
is_obsolete: true
consider: GO:0044304

[Term]
id: GO:1990751
name: Schwann cell chemotaxis
namespace: biological_process
def: "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995]
is_a: GO:0036135 ! Schwann cell migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:1990752
name: microtubule end
namespace: cellular_component
def: "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr]
comment: This term should be used when it is not possible to distinguish between the two microtubule ends, e.g. during image annotation. Whenever possible, please annotate to one of the more specific children GO:0035371 'microtubule plus-end' or GO:0036449 'microtubule minus-end'.
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005874 ! microtubule

[Term]
id: GO:1990753
name: equatorial cell cortex
namespace: cellular_component
def: "The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression." [GOC:kmv, PMID:16352658, PMID:22552143, PMID:23750214, PMID:25898168]
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:1990754
name: obsolete GABAergic neuronal action potential
namespace: biological_process
def: "OBSOLETE. An action potential that occurs in a GABAergic neuron." [PMID:16921370]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "GABAergic neuronal action potential" EXACT []
is_obsolete: true

[Term]
id: GO:1990755
name: mitotic spindle microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle." [PMID:25253718]
synonym: "mitotic spindle microtubule depolymerisation" EXACT []
is_a: GO:0007019 ! microtubule depolymerization

[Term]
id: GO:1990756
name: ubiquitin-like ligase-substrate adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]
synonym: "protein binding, bridging involved in substrate recognition for ubiquitination" EXACT []
synonym: "ubiquitin ligase substrate adaptor" EXACT []
synonym: "ubiquitin ligase-substrate adaptor activity" NARROW []
synonym: "UFM1 ligase-substrate adaptor activity" NARROW []
is_a: GO:0140767 ! enzyme-substrate adaptor activity

[Term]
id: GO:1990757
name: ubiquitin ligase activator activity
namespace: molecular_function
alt_id: GO:0061636
def: "Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242]
synonym: "mitotic anaphase-promoting complex activator activity" NARROW []
is_a: GO:0097027 ! ubiquitin-protein transferase activator activity

[Term]
id: GO:1990758
name: mitotic sister chromatid biorientation
namespace: biological_process
def: "The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression." [PMID:15309047, PMID:26258632, PMID:26705896]
is_a: GO:0031134 ! sister chromatid biorientation
is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:1990760
name: osmolarity-sensing monoatomic cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides." [PMID:18279313]
synonym: "osmolarity-sensing cation channel activity" BROAD []
is_a: GO:0005034 ! osmosensor activity
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0022836 ! gated channel activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:1990761
name: growth cone lamellipodium
namespace: cellular_component
def: "A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments." [GOC:dos, PMID:25598228]
is_a: GO:0030027 ! lamellipodium
is_a: GO:0043005 ! neuron projection
relationship: part_of GO:0030426 ! growth cone

[Term]
id: GO:1990762
name: cytoplasmic alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation." [GOC:vw]
is_a: GO:0006419 ! alanyl-tRNA aminoacylation
relationship: part_of GO:0002181 ! cytoplasmic translation

[Term]
id: GO:1990763
name: arrestin family protein binding
namespace: molecular_function
def: "Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors." [PMID:23911909]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:1990764
name: myofibroblast contraction
namespace: biological_process
def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast." [PMID:19239477]
synonym: "MF contraction" EXACT []
synonym: "MFB contraction" EXACT []
is_a: GO:0070252 ! actin-mediated cell contraction

[Term]
id: GO:1990765
name: colon smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253]
is_a: GO:0006939 ! smooth muscle contraction
relationship: part_of GO:0014827 ! intestine smooth muscle contraction

[Term]
id: GO:1990767
name: prostaglandin receptor internalization
namespace: biological_process
def: "The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle." [PMID:15937517]
is_a: GO:0002031 ! G protein-coupled receptor internalization

[Term]
id: GO:1990768
name: gastric mucosal blood circulation
namespace: biological_process
def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413]
synonym: "stomach mucosal blood circulation" EXACT []
is_a: GO:0008015 ! blood circulation

[Term]
id: GO:1990769
name: proximal neuron projection
namespace: cellular_component
def: "The portion of an axon or dendrite that is close to the neuronal cell body." [PMID:21104189]
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:1990770
name: small intestine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626]
is_a: GO:0006939 ! smooth muscle contraction
relationship: part_of GO:0014827 ! intestine smooth muscle contraction

[Term]
id: GO:1990771
name: clathrin-dependent extracellular exosome endocytosis
namespace: biological_process
def: "The clathrin-mediated endocytosis of an extracellular exosome." [PMID:24951588]
synonym: "clathrin-mediated extracellular exosome endocytosis" EXACT []
synonym: "exosome related" EXACT []
is_a: GO:0051650 ! establishment of vesicle localization
is_a: GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:1990772
name: substance P secretion
namespace: biological_process
def: "The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity." [PMID:11278900]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:1990773
name: matrix metallopeptidase secretion
namespace: biological_process
def: "The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins." [PMID:8679543]
synonym: "matrix metalloproteinase secretion" NARROW []
synonym: "MMP secretion" EXACT []
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:1990775
name: endothelin production
namespace: biological_process
def: "The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120]
subset: gocheck_do_not_annotate
synonym: "EDN1 production" NARROW []
synonym: "EDN2 production" NARROW []
synonym: "EDN3 production" NARROW []
synonym: "endothelin secretion" NARROW []
synonym: "endothelin-1 secretion" NARROW []
synonym: "endothelin-2 production" NARROW []
synonym: "endothelin-3 production" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:1990776
name: response to angiotensin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [PMID:22982863]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:1990777
name: lipoprotein particle
namespace: cellular_component
def: "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." [GOC:vesicles]
is_a: GO:0032994 ! protein-lipid complex

[Term]
id: GO:1990778
name: protein localization to cell periphery
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:1990779
name: glycoprotein Ib-IX-V complex
namespace: cellular_component
def: "A transmembrane signaling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation." [GOC:bhm, PMID:1730602, PMID:23336709, PMID:25297919]
comment: An example of this is GB1BA in human (P07359) in PMID:1730602 (inferred from direct assay).
synonym: "CD42" EXACT []
synonym: "GPIb-IX-V complex" EXACT []
synonym: "GPIb-V-IX complex" EXACT []
is_a: GO:0090665 ! glycoprotein complex
is_a: GO:0098802 ! plasma membrane signaling receptor complex

[Term]
id: GO:1990780
name: cytoplasmic side of dendritic spine plasma membrane
namespace: cellular_component
def: "The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine." [PMID:9275233]
is_a: GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0032591 ! dendritic spine membrane

[Term]
id: GO:1990781
name: response to immobilization stress combined with electrical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile." [PMID:17008368]
is_a: GO:0035902 ! response to immobilization stress
is_a: GO:0051602 ! response to electrical stimulus

[Term]
id: GO:1990782
name: protein tyrosine kinase binding
namespace: molecular_function
def: "Binding to protein tyrosine kinase." [PMID:25499537]
synonym: "tyrosine kinase binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:1990783
name: periphagosomal region of cytoplasm
namespace: cellular_component
def: "Cytoplasm situated near, or occurring around, a phagosome." [PMID:18250451]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:1990784
name: response to dsDNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633]
synonym: "response to double-stranded DNA" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:1990785
name: response to water-immersion restraint stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile." [PMID:10882227]
synonym: "response to immobilization stress combined with water immersion" EXACT []
is_a: GO:0035902 ! response to immobilization stress

[Term]
id: GO:1990786
name: cellular response to dsDNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1990784 ! response to dsDNA

[Term]
id: GO:1990787
name: negative regulation of hh target transcription factor activity
namespace: biological_process
def: "Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling." [GOC:bhm, PMID:24311597]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of hedgehog target transcription factor" EXACT []
is_a: GO:0045879 ! negative regulation of smoothened signaling pathway
is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity

[Term]
id: GO:1990788
name: GLI-SUFU complex
namespace: cellular_component
def: "A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins." [GOC:bhm, PMID:24311597]
comment: An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay).
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:1990789
name: thyroid gland epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population." [PMID:17646383]
synonym: "Hurthle cell proliferation" NARROW []
synonym: "thyroid follicular cell proliferation" NARROW []
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0030878 ! thyroid gland development

[Term]
id: GO:1990790
name: response to glial cell derived neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310]
synonym: "response to astrocyte-derived trophic factor" EXACT []
synonym: "response to ATF" EXACT []
synonym: "response to GDNF" EXACT []
is_a: GO:0070848 ! response to growth factor

[Term]
id: GO:1990791
name: dorsal root ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure." [PMID:18583150]
synonym: "DRG development" EXACT []
is_a: GO:0061548 ! ganglion development

[Term]
id: GO:1990792
name: cellular response to glial cell derived neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310]
synonym: "cellular response to astrocyte-derived trophic factor" EXACT []
synonym: "cellular response to ATF" EXACT []
synonym: "cellular response to GDNF" EXACT []
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:1990790 ! response to glial cell derived neurotrophic factor

[Term]
id: GO:1990793
name: substance P secretion, neurotransmission
namespace: biological_process
def: "The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter." [PMID:15292051]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:1990772 ! substance P secretion

[Term]
id: GO:1990794
name: basolateral part of cell
namespace: cellular_component
def: "The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells." [PMID:18495799]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0045178 ! basal part of cell
relationship: part_of GO:0097574 ! lateral part of cell

[Term]
id: GO:1990795
name: rod bipolar cell terminal bouton
namespace: cellular_component
def: "A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [PMID:19883736]
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:1990796
name: photoreceptor cell terminal bouton
namespace: cellular_component
def: "A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light." [PMID:19883736]
is_a: GO:0043195 ! terminal bouton

[Term]
id: GO:1990797
name: obsolete cholecystokinin secretion
namespace: biological_process
def: "OBSOLETE. The controlled release of cholecystokinin from a cell. Cholecystokinin is a peptide hormone that participates in pancreatic enzyme release in the gut and is also found in the brain." [PMID:2755938]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "CCK secretion" EXACT []
is_obsolete: true

[Term]
id: GO:1990798
name: pancreas regeneration
namespace: biological_process
def: "The regrowth of a destroyed pancreas." [PMID:1985964]
is_a: GO:0031100 ! animal organ regeneration

[Term]
id: GO:1990799
name: mitochondrial tRNA wobble position uridine thiolation
namespace: biological_process
def: "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:15509579]
is_a: GO:0002143 ! tRNA wobble position uridine thiolation
is_a: GO:0070899 ! mitochondrial tRNA wobble uridine modification
is_a: GO:0070903 ! mitochondrial tRNA thio-modification

[Term]
id: GO:1990800
name: obsolete meiotic APC-fizzy-related complex
namespace: cellular_component
def: "OBSOLETE. An anaphase promoting complex bound to a fizzy-related family APC activator that regulates meiotic exit by activating the APC/C to target meiotic cyclins for destruction during meiosis." [PMID:11493649]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990801
name: obsolete protein phosphorylation involved in mitotic spindle assembly
namespace: biological_process
def: "OBSOLETE. Any protein phosphorylation that is involved in mitotic spindle assembly." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21558801]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "protein amino acid phosphorylation involved in mitotic spindle assembly" EXACT []
synonym: "protein amino acid phosphorylation involved in spindle assembly involved in mitosis" EXACT []
synonym: "protein phosphorylation involved in spindle assembly involved in mitosis" EXACT []
is_obsolete: true

[Term]
id: GO:1990802
name: obsolete protein phosphorylation involved in DNA double-strand break processing
namespace: biological_process
def: "OBSOLETE. Any protein phosphorylation that is required for DNA double-strand break processing." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21841787]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "protein amino acid phosphorylation involved in DNA double-strand break processing" EXACT []
is_obsolete: true

[Term]
id: GO:1990803
name: obsolete protein phosphorylation involved in protein localization to spindle microtubule
namespace: biological_process
def: "OBSOLETE. Any protein phosphorylation process involved in localizing a protein to the spindle microtubule." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22521784]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "protein amino acid phosphorylation involved in protein localisation in spindle microtubule" EXACT []
synonym: "protein amino acid phosphorylation involved in protein localisation to spindle microtubule" EXACT []
synonym: "protein amino acid phosphorylation involved in protein localization in spindle microtubule" EXACT []
synonym: "protein amino acid phosphorylation involved in protein localization to spindle microtubule" EXACT []
synonym: "protein phosphorylation involved in protein localisation in spindle microtubule" EXACT []
synonym: "protein phosphorylation involved in protein localisation to spindle microtubule" EXACT []
synonym: "protein phosphorylation involved in protein localization in spindle microtubule" EXACT []
is_obsolete: true

[Term]
id: GO:1990804
name: obsolete protein phosphorylation involved in double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "OBSOLETE. Any protein phosphorylation process that is required for double-strand break repair via nonhomologous end joining." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22563681]
comment: This term has been obsoleted because it represents a GO-CAM model.
synonym: "protein amino acid phosphorylation involved in double-strand break repair via nonhomologous end joining" EXACT []
synonym: "protein amino acid phosphorylation involved in NHEJ" EXACT []
synonym: "protein phosphorylation involved in NHEJ" EXACT []
is_obsolete: true

[Term]
id: GO:1990805
name: central cylinder
namespace: cellular_component
def: "A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules." [GOC:kmv, PMID:2428682, PMID:26124290]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0035869 ! ciliary transition zone

[Term]
id: GO:1990806
name: ligand-gated ion channel signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25869137]
synonym: "ligand-gated ion channel signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:1990807
name: obsolete protein N-acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an acetyl group to a nitrogen atom on the amino acid of a protein." [GOC:dph]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990808
name: F-bar domain binding
namespace: molecular_function
def: "Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins." [PMID:20603077]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:1990809
name: endoplasmic reticulum tubular network membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane." [PMID:20434336]
is_a: GO:0071786 ! endoplasmic reticulum tubular network organization
is_a: GO:0090158 ! endoplasmic reticulum membrane organization

[Term]
id: GO:1990810
name: microtubule anchoring at mitotic spindle pole body
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:17486116]
is_a: GO:0034631 ! microtubule anchoring at spindle pole body
is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis
relationship: part_of GO:0090307 ! mitotic spindle assembly

[Term]
id: GO:1990811
name: MWP complex
namespace: cellular_component
def: "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin." [PMID:25987607, PMID:29021344]
synonym: "Msd1-Wdr8-Pkl1 complex" EXACT [GOC:vw]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990812
name: growth cone filopodium
namespace: cellular_component
def: "A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone." [PMID:25598228]
is_a: GO:0030175 ! filopodium
is_a: GO:0043005 ! neuron projection
relationship: part_of GO:0030426 ! growth cone

[Term]
id: GO:1990813
name: meiotic centromeric cohesion protection in anaphase I
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation at meiotic anaphase I after cohesin is cleaved by separase along the arm regions." [PMID:14730319, PMID:25533956]
synonym: "anaphase cohesion protection" EXACT []
synonym: "protection of centromeric cohesion during meiotic anaphase I" EXACT []
is_a: GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:1990814
name: DNA/DNA annealing activity
namespace: molecular_function
def: "An activity that facilitates the formation of a complementary double-stranded DNA molecule." [PMID:22888405, PMID:25520186]
synonym: "DNA reannealing activity" EXACT []
is_a: GO:0003697 ! single-stranded DNA binding
is_a: GO:0140666 ! annealing activity

[Term]
id: GO:1990815
name: obsolete regulation of protein localization to cell division site after cytokinesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990816
name: vacuole-mitochondrion membrane contact site
namespace: cellular_component
def: "A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles." [PMID:25026035, PMID:25026036]
synonym: "vacuole and mitochondria patch" EXACT []
synonym: "vCLAMP" EXACT []
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:1990817
name: poly(A) RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]
synonym: "NTP polymerase activity" BROAD [EC:2.7.7.19]
synonym: "poly(A) polymerase activity" RELATED [EC:2.7.7.19]
synonym: "polynucleotide adenylyltransferase activity" EXACT []
synonym: "RNA adenylating enzyme" EXACT [EC:2.7.7.19]
synonym: "RNA adenyltransferase activity" EXACT []
synonym: "RNA adenylyltransferase activity" EXACT []
xref: EC:2.7.7.19
xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN
xref: Reactome:R-HSA-72185 "mRNA polyadenylation"
xref: Reactome:R-HSA-9833031 "Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs"
xref: RHEA:11332
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:1990818
name: L-arginine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane." [PMID:26083598]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:1990819
name: mating projection actin fusion focus
namespace: cellular_component
def: "A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location." [PMID:25825517]
synonym: "actin fusion focus" BROAD []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0015629 ! actin cytoskeleton
relationship: part_of GO:0043332 ! mating projection tip

[Term]
id: GO:1990820
name: response to mitotic DNA integrity checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling." [PMID:7548844]
synonym: "response to signal involved in mitotic DNA integrity checkpoint" EXACT []
is_a: GO:0072402 ! response to DNA integrity checkpoint signaling
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling

[Term]
id: GO:1990822
name: basic amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of basic amino acids from one side of a membrane to the other." [GOC:dph, GOC:vw]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015802 ! basic amino acid transport

[Term]
id: GO:1990823
name: response to leukemia inhibitory factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913]
synonym: "response to CDF" EXACT []
synonym: "response to cholinergic differentiation factor" EXACT []
synonym: "response to LIF" EXACT []
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:1990824
name: obsolete magnesium-dependent protein complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that depends on magnesium in order for one or more of its components to remain a part of the complex." [PMID:10220587]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990825
name: sequence-specific mRNA binding
namespace: molecular_function
def: "Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:1990826
name: nucleoplasmic periphery of the nuclear pore complex
namespace: cellular_component
def: "Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex." [PMID:10633080]
synonym: "associated with the nuclear pore" RELATED [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:1990827
name: deaminase binding
namespace: molecular_function
def: "Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)." [PMID:9792439]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:1990828
name: hepatocyte dedifferentiation
namespace: biological_process
def: "The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [PMID:20102719]
is_a: GO:0043697 ! cell dedifferentiation

[Term]
id: GO:1990829
name: C-rich single-stranded DNA binding
namespace: molecular_function
def: "Binding to C-rich, single-stranded DNA." [PMID:8127654]
synonym: "C-rich ssDNA binding" EXACT []
is_a: GO:0003697 ! single-stranded DNA binding

[Term]
id: GO:1990830
name: cellular response to leukemia inhibitory factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913]
synonym: "cellular response to CDF" EXACT []
synonym: "cellular response to cholinergic differentiation factor" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:1990823 ! response to leukemia inhibitory factor

[Term]
id: GO:1990831
name: cellular response to carcinoembryonic antigen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins." [PMID:10202129, PMID:14597422]
synonym: "cellular response to pregnancy specific glycoprotein" EXACT []
is_a: GO:1904588 ! cellular response to glycoprotein

[Term]
id: GO:1990832
name: slow axonal transport
namespace: biological_process
def: "The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition." [PMID:6378920]
is_a: GO:0008088 ! axo-dendritic transport

[Term]
id: GO:1990833
name: clathrin-uncoating ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP." [PMID:6146630, PMID:8363588]
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:1990834
name: response to odorant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell." [PMID:11268007]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:1990835
name: obsolete insulin-like growth factor production
namespace: biological_process
def: "OBSOLETE. The appearance of an insulin-like growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [PMID:21993393]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "IGF production" RELATED []
is_obsolete: true

[Term]
id: GO:1990836
name: lysosomal matrix
namespace: cellular_component
def: "A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome." [PMID:9395337]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0043202 ! lysosomal lumen

[Term]
id: GO:1990837
name: sequence-specific double-stranded DNA binding
namespace: molecular_function
def: "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]
synonym: "sequence-specific dsDNA binding" EXACT []
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:1990838
name: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
namespace: molecular_function
def: "Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)." [PMID:23022480]
is_a: GO:0000175 ! 3'-5'-RNA exonuclease activity

[Term]
id: GO:1990839
name: response to endothelin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:1990840
name: response to lectin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444]
comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity.
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:1990841
name: promoter-specific chromatin binding
namespace: molecular_function
def: "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]
is_a: GO:0003682 ! chromatin binding

[Term]
id: GO:1990842
name: obsolete response to prenatal stress
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis in the embryo or fetus during pregnancy." [PMID:22738222]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to PNS" EXACT []
is_obsolete: true

[Term]
id: GO:1990843
name: obsolete subsarcolemmal mitochondrion
namespace: cellular_component
def: "OBSOLETE. A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174]
comment: This term was obsoleted because it corresponds to mitochondria of specific cell types and this information should be captured as an extension.
synonym: "SS mitochondrion" EXACT []
synonym: "SSM" EXACT []
is_obsolete: true
consider: GO:0005739

[Term]
id: GO:1990844
name: obsolete interfibrillar mitochondrion
namespace: cellular_component
def: "OBSOLETE. A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174]
comment: This term was obsoleted because it corresponds to mitochondria of specific cell types and this information should be captured as an extension.
synonym: "IFM" EXACT []
synonym: "IMF mitochondrion" EXACT []
synonym: "intermyofibrillar mitochondrion" EXACT []
is_obsolete: true

[Term]
id: GO:1990845
name: adaptive thermogenesis
namespace: biological_process
def: "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:1990846
name: ribonucleoside-diphosphate reductase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase." [PMID:16317005]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:1990847
name: obsolete peptide pheromone transmembrane export involved in positive regulation of conjugation with cellular fusion
namespace: biological_process
def: "OBSOLETE. The directed movement of a peptide pheromone across a membrane and out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [PMID:9236781]
comment: This term was obsoleted because it represents a BP in a BP and should be captured with a GO-CAM model
is_obsolete: true

[Term]
id: GO:1990848
name: obsolete Positive regulation of removal of reactive oxygen species
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of removal of reactive oxygen species in a cell." [PMID:24118096]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990849
name: vacuolar localization
namespace: biological_process
def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797]
synonym: "maintenance of vacuolar localization" EXACT []
synonym: "maintenance of vacuolar location" NARROW []
synonym: "maintenance of vacuole localization" EXACT []
synonym: "maintenance of vacuole location" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:1990850
name: H-gal-GP complex
namespace: cellular_component
def: "A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus." [PMID:11166393]
synonym: "galactose-containing glycoprotein complex" NARROW []
synonym: "Haemonchus galactose-containing glycoprotein complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:1990851
name: Wnt-Frizzled-LRP5/6 complex
namespace: cellular_component
def: "A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6." [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360]
comment: Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form.
synonym: "Frizzled-LRP5/6 complex" RELATED [GOC:bf]
synonym: "Fz/Wnt/LRP6 complex" NARROW [PMID:20093360]
synonym: "Wnt receptor complex" BROAD [GOC:bf]
synonym: "WNT-FZD-LRP5 complex" NARROW [PMID:23209147]
synonym: "Wnt-FZD-LRP5/6 trimeric complex" EXACT [PMID:23209147]
synonym: "WNT-FZD-LRP6 complex" NARROW [PMID:23209147]
synonym: "Wnt-induced Frizzled-LRP5/6 complex" RELATED [GOC:bf]
synonym: "Wnt.Fz.LRP ternary complex" EXACT [PMID:20093360]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:1990852
name: protein transport along microtubule to spindle pole body
namespace: biological_process
def: "The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins." [PMID:25987607]
is_a: GO:0071989 ! establishment of protein localization to spindle pole body
is_a: GO:0098840 ! protein transport along microtubule

[Term]
id: GO:1990853
name: obsolete histone H2A SQE motif phosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone." [DOI:10.1038/35052000, PMID:15226425]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990854
name: vacuole-ER tethering
namespace: biological_process
def: "The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles." [PMID:26283797]
synonym: "vacuole-endoplasmic reticulum attachment" EXACT []
synonym: "vacuole-endoplasmic reticulum tethering" EXACT []
synonym: "vacuole-ER attachment" EXACT []
is_a: GO:0016043 ! cellular component organization
is_a: GO:0051685 ! maintenance of ER location
is_a: GO:0140056 ! organelle localization by membrane tethering
is_a: GO:1990849 ! vacuolar localization

[Term]
id: GO:1990855
name: obsolete myo-inositol import across plasma membrane
namespace: biological_process
def: "OBSOLETE. The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell across the plasma membrane." [PMID:9560432]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990856
name: methionyl-initiator methionine tRNA binding
namespace: molecular_function
def: "Binding to methionine-initiator methionine tRNA." [GOC:hjd, ISBN:9781555810733]
comment: An example of this is eukaryotic initiation factor 2 complex, which binds the methionyl-initiator methionine tRNA during ternary complex formation. The non-acylated tRNA is not bound.
is_a: GO:0000049 ! tRNA binding

[Term]
id: GO:1990857
name: obsolete APC-Fzr1/Mfr1 complex
namespace: cellular_component
def: "OBSOLETE. An anaphase promoting complex bound to an activator in the Fzr1 (human)/Mfr1 (pombe) family." [PMID:11493649]
comment: This term was made obsolete because it is too fine-grained for GO.
is_obsolete: true
consider: GO:0005680

[Term]
id: GO:1990858
name: cellular response to lectin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444]
comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity.
is_a: GO:1990840 ! response to lectin

[Term]
id: GO:1990859
name: cellular response to endothelin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990839 ! response to endothelin

[Term]
id: GO:1990860
name: Pho85-Pho80 CDK-cyclin complex
namespace: cellular_component
def: "A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin." [GOC:rb, PMID:8108735]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:1990861
name: Ubp3-Bre5 deubiquitination complex
namespace: cellular_component
def: "A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p." [GOC:rb, PMID:12778054, PMID:18391941]
synonym: "Ubp3-Bre5 ubiquitin protease complex" EXACT []
is_a: GO:1905368 ! peptidase complex

[Term]
id: GO:1990862
name: nuclear membrane complex Bqt3-Bqt4
namespace: cellular_component
def: "A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4." [PMID:19948484]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0005637 ! nuclear inner membrane

[Term]
id: GO:1990863
name: acinar cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538]
synonym: "acinic cell proliferation" EXACT []
synonym: "acinous cell proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:1990864
name: response to growth hormone-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins." [PMID:7720628]
synonym: "response to GHRF" EXACT []
synonym: "response to GRF" EXACT []
synonym: "response to growth hormone-releasing factor" EXACT []
synonym: "response to sermorelin" RELATED []
synonym: "response to somatocrinin" EXACT []
synonym: "response to somatoliberin" EXACT []
synonym: "response to somatorelin" EXACT []
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:1990865
name: obsolete response to intermittent hypoxia
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension." [PMID:24055447]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990866
name: obsolete response to sustained hypoxia
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension." [PMID:24055447]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990867
name: response to gastrin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:1990868
name: response to chemokine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:1990869
name: cellular response to chemokine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:1990868 ! response to chemokine

[Term]
id: GO:1990870
name: obsolete protein fibril
namespace: cellular_component
def: "OBSOLETE. A polymer of proteins that form a fine fiber." [PMID:12764608]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990871
name: Vma12-Vma22 assembly complex
namespace: cellular_component
def: "A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p." [GOC:rb, PMID:9660861]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990872
name: obsolete negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of sterol import, by down regulation of transcription from an RNA polymerase II promoter." [GOC:rb, PMID:19793923]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:1990873
name: obsolete intrinsic component of plasma membrane of cell tip
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip." [PMID:20624220]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0031520

[Term]
id: GO:1990874
name: vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467]
synonym: "vascular smooth muscle cell proliferation" EXACT []
synonym: "VSMC proliferation" EXACT []
is_a: GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:1990875
name: nucleoplasmic side of nuclear pore
namespace: cellular_component
def: "The side of the nuclear pore complex (NPC) that faces the nucleoplasm." [PMID:8422679]
synonym: "nucleoplasmic side of NPC" EXACT []
synonym: "nucleoplasmic side of nuclear pore complex" EXACT []
synonym: "nucleoplasmic side of nucleopore" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:1990876
name: cytoplasmic side of nuclear pore
namespace: cellular_component
def: "The side of the nuclear pore complex (NPC) that faces the cytoplasm." [PMID:8422679]
synonym: "cytoplasmic side of NPC" EXACT []
synonym: "cytoplasmic side of nuclear pore complex" EXACT []
synonym: "cytoplasmic side of nucleopore" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:1990877
name: FNIP-folliculin RagC/D GAP
namespace: cellular_component
def: "A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2." [GOC:rn, PMID:24095279, PMID:26387955, PMID:34805795]
synonym: "BFC complex" EXACT [PMID:34805795]
synonym: "FLCN-FNIP1 complex" EXACT []
synonym: "FLCN-FNIP2 complex" EXACT []
synonym: "FNIP-Folliculin RagC/D GAP complex" EXACT []
synonym: "Lst4-Lst7 complex" EXACT []
is_a: GO:1902773 ! GTPase activator complex

[Term]
id: GO:1990878
name: cellular response to gastrin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990867 ! response to gastrin

[Term]
id: GO:1990879
name: CST complex
namespace: cellular_component
def: "A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19854130, PMID:22965356]
synonym: "Cdc13-Stn1-Ten1 complex" NARROW [GOC:nc]
synonym: "CTC1-OBFC1-TEN1 complex" NARROW [GOC:nc]
is_a: GO:0000783 ! nuclear telomere cap complex

[Term]
id: GO:1990880
name: cellular detoxification of copper ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [PMID:10369673]
is_a: GO:0010273 ! detoxification of copper ion
is_a: GO:0140961 ! cellular detoxification of metal ion
relationship: part_of GO:0071280 ! cellular response to copper ion

[Term]
id: GO:1990881
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to DNA damage
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:26150418]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0006974

[Term]
id: GO:1990882
name: rRNA acetylation
namespace: biological_process
def: "The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [PMID:25402480]
is_a: GO:0000154 ! rRNA modification
is_a: GO:1990884 ! RNA acetylation

[Term]
id: GO:1990883
name: rRNA cytidine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA." [PMID:25402480]
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:1990884
name: RNA acetylation
namespace: biological_process
def: "The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule." [PMID:25402480]
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:1990885
name: obsolete protein serine/threonine kinase binding
namespace: molecular_function
def: "OBSOLETE. Binding to a protein serine/threonine kinase." [PMID:16982699]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990887
name: obsolete 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+." [PMID:10419476]
comment: This term was obsoleted because it represents the same reaction as 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity ; GO:0010420.
is_obsolete: true
replaced_by: GO:0010420

[Term]
id: GO:1990888
name: 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+." [PMID:10419476]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:1990889
name: H4K20me3 histone reader activity
namespace: molecular_function
def: "A histone reader that recognizes a histone H4 trimethylated at lysine 20." [PMID:22150589]
synonym: "H4K20me3 modified histone binding" NARROW []
is_a: GO:0140566 ! histone reader activity

[Term]
id: GO:1990890
name: netrin receptor binding
namespace: molecular_function
def: "Binding to a netrin receptor." [GOC:kmv, PMID:8861902, PMID:9126742]
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:1990891
name: mitotic sister chromatid arm separation
namespace: biological_process
def: "The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis." [PMID:21633354]
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0051306 ! mitotic sister chromatid separation

[Term]
id: GO:1990892
name: mitotic chromosome arm condensation
namespace: biological_process
def: "The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [PMID:21633354]
is_a: GO:0007076 ! mitotic chromosome condensation

[Term]
id: GO:1990893
name: mitotic chromosome centromere condensation
namespace: biological_process
def: "The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis." [PMID:21633354]
synonym: "mitotic chromosome condensation at kinetochore" EXACT []
is_a: GO:0007076 ! mitotic chromosome condensation

[Term]
id: GO:1990894
name: obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [PMID:22144909]
comment: This term was obsoleted during the TG review process. It should have been created using a template.
is_obsolete: true

[Term]
id: GO:1990895
name: regulation of protein localization to cell cortex of cell tip
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [GOC:vw, PMID:26150232]
is_a: GO:1903066 ! regulation of protein localization to cell tip
is_a: GO:1904776 ! regulation of protein localization to cell cortex
relationship: regulates GO:1990896 ! protein localization to cell cortex of cell tip

[Term]
id: GO:1990896
name: protein localization to cell cortex of cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip." [PMID:26150232]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:1990151 ! protein localization to cell tip

[Term]
id: GO:1990897
name: obsolete CTDK-1 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that phosphorylates serine 2 residues in the CTD domain of productively elongating large subunits of DNA-directed RNA polymerase II, holoenzyme. In S. cerevisiae this complex consists of CTK1/CTK2/CTK3, in S. pombe Lsk1/Lsc1/Lsg1. Human CTK1 homologs include CDK12/13." [PMID:20952539, PMID:24879308]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990898
name: obsolete meiotic DNA double-strand break clipping
namespace: biological_process
def: "OBSOLETE. The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP)." [PMID:26130711]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990899
name: obsolete meiotic DNA double-strand break resectioning
namespace: biological_process
def: "OBSOLETE. The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends." [PMID:26130711]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:1990900
name: ciliary pocket collar
namespace: cellular_component
def: "A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma." [GOC:giardia, PMID:18462016, PMID:19806154]
comment: Note that a 'flagellar collar' is described in Choanoflagellates, but this is different from the ciliary pocket collar found e.g. in Giardia; in Choanoflagellates, a single apical flagellum is surrounded by a collar of 30-40 microvilli.
synonym: "cilium pocket collar" EXACT []
synonym: "flagellar collar" RELATED []
synonym: "flagellar pocket collar" EXACT []
synonym: "flagellar pore" RELATED []
synonym: "flagellum pocket collar" EXACT []
synonym: "FPC" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0020016 ! ciliary pocket

[Term]
id: GO:1990901
name: old cell pole
namespace: cellular_component
def: "The cell pole distal from the most recent cell division." [GOC:jh2, PMID:10231492, PMID:8226658]
is_a: GO:0060187 ! cell pole

[Term]
id: GO:1990902
name: new cell pole
namespace: cellular_component
def: "The cell pole proximal to the most recent cell division." [GOC:jh2, PMID:10231492, PMID:8226658]
is_a: GO:0060187 ! cell pole

[Term]
id: GO:1990904
name: ribonucleoprotein complex
namespace: cellular_component
alt_id: GO:0030529
alt_id: GO:1990903
def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]
subset: goslim_pir
synonym: "extracellular ribonucleoprotein complex" NARROW []
synonym: "intracellular ribonucleoprotein complex" NARROW []
synonym: "protein-RNA complex" EXACT []
synonym: "RNA-protein complex" EXACT []
synonym: "RNP" EXACT []
xref: Wikipedia:Ribonucleoprotein
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990905
name: dinoflagellate peduncle
namespace: cellular_component
def: "A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy)." [GOC:at, PMID:1480107, Wikipedia:Dinoflagellate]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:1990906
name: accessory outer segment
namespace: cellular_component
def: "A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors." [GOC:dph, PMID:25125189]
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:1990907
name: beta-catenin-TCF complex
namespace: cellular_component
def: "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors." [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]
synonym: "beta-catenin/LEF complex" NARROW [PMID:8757136]
synonym: "beta-catenin/lymphoid enhancer binding factor complex" RELATED [PMID:8757136]
synonym: "beta-catenin/T-cell factor complex" RELATED [GOC:bf]
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex

[Term]
id: GO:1990908
name: obsolete Lys63-specific zinc metallopeptidase deubiquitinase activity
namespace: molecular_function
def: "OBSOLETE. Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein by a mechanism where zinc acts as the nucleophile." [PMID:26368668]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990909
name: Wnt signalosome
namespace: cellular_component
def: "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]
comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
synonym: "LRP5/6 signalosome" EXACT [GOC:bf]
synonym: "LRP6 signalosome" NARROW [PMID:22899650, PMID:25074807]
synonym: "Wnt signalosome complex" EXACT [PMID:24412065]
synonym: "Wnt-LRP5/6 signalosome" EXACT [PMID:23892894]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990910
name: response to hypobaric hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level)." [PMID:24590457]
is_a: GO:0001666 ! response to hypoxia

[Term]
id: GO:1990911
name: response to psychosocial stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism." [PMID:22922217, PMID:26458179]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:1990912
name: obsolete response to microwave radiation
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microwave radiation stimulus." [PMID:21241601]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990913
name: sperm head plasma membrane
namespace: cellular_component
def: "The plasma membrane that is part of the head section of a sperm cell." [PMID:24478030]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0061827 ! sperm head
relationship: part_of GO:0097524 ! sperm plasma membrane

[Term]
id: GO:1990914
name: obsolete integral component of periplasmic side of plasma membrane
namespace: cellular_component
def: "OBSOLETE. The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane." [GOC:bhm, PMID:15919996]
comment: This term was obsoleted because it represents protein topology, not a cellular component.
is_obsolete: true
replaced_by: GO:0098567

[Term]
id: GO:1990915
name: structural constituent of ascospore wall
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an ascospore wall." [PMID:24623719]
is_a: GO:0005199 ! structural constituent of cell wall

[Term]
id: GO:1990916
name: Isp3 layer of spore wall
namespace: cellular_component
def: "The outermost layers of the spore wall, as described in Schizosaccharomyces pombe." [PMID:24623719]
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:1990917
name: ooplasm
namespace: cellular_component
def: "The cytoplasm of an ovum." [PMID:19022436]
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:1990918
name: double-strand break repair involved in meiotic recombination
namespace: biological_process
def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514]
is_a: GO:0006302 ! double-strand break repair
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:1990919
name: proteasome-nuclear membrane anchor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome." [PMID:16096059]
synonym: "nuclear membrane proteasome adaptor" RELATED []
synonym: "nuclear membrane proteasome anchor" EXACT []
synonym: "nuclear membrane proteasome tether" EXACT []
synonym: "nuclear membrane proteasome tether activity" EXACT []
synonym: "nuclear membrane-proteasome anchor activity" EXACT []
synonym: "nuclear membrane-proteasome tether activity" EXACT []
synonym: "tethering factor for nuclear proteasome" RELATED []
is_a: GO:0043495 ! protein-membrane adaptor activity

[Term]
id: GO:1990920
name: obsolete proteasome localization to nuclear periphery
namespace: biological_process
def: "OBSOLETE. Any process in which the proteasome is transported to, or maintained at the nuclear periphery." [PMID:11084332]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:1990919

[Term]
id: GO:1990921
name: obsolete proteasome localization to nuclear periphery
namespace: biological_process
def: "OBSOLETE. A process in which a proteasome is transported to, or maintained in, a location within the nuclear periphery." [PMID:16096059]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "proteasome localisation to nuclear periphery" EXACT []
is_obsolete: true

[Term]
id: GO:1990922
name: hepatic stellate cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:sl, PMID:15358192, PMID:18466260]
synonym: "hepatic perisinusoidal cell proliferation" EXACT []
synonym: "Ito cell proliferation" EXACT []
synonym: "perisinusoidal cell proliferation" EXACT []
is_a: GO:0048144 ! fibroblast proliferation

[Term]
id: GO:1990923
name: PET complex
namespace: cellular_component
def: "A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs." [PMID:26669262]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990924
name: obsolete amphisome membrane
namespace: cellular_component
def: "OBSOLETE. The lipid bilayer surrounding the amphisome and separating its contents from the cell cytoplasm." [GOC:bhm, PMID:17984323]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "amphisomal membrane" EXACT []
is_obsolete: true

[Term]
id: GO:1990926
name: short-term synaptic potentiation
namespace: biological_process
def: "The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds." [GOC:dos, GOC:sp, ISBN:9780071120005, PMID:11826273, PMID:26738595]
comment: The mechanism of short term potentiation is thought to be either increased influx of calcium into the presynapse (Zucker and Regeh, 2002 PMID:11826273) increased sensitivity to calcium (Jackman et al., 2016 PMID:26738595) or both.
synonym: "synaptic facilitation" EXACT [ISBN:9780071120005, PMID:11826273, PMID:26738595]
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:1990927
name: calcium ion regulated lysosome exocytosis
namespace: biological_process
def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [PMID:10725327, PMID:11511344]
is_a: GO:0017156 ! calcium-ion regulated exocytosis

[Term]
id: GO:1990928
name: response to amino acid starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [PMID:7765311]
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:1990929
name: sulfoquinovosidase activity
namespace: molecular_function
def: "Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose." [GOC:imk, PMID:26878550]
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:1990930
name: mRNA N1-methyladenosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde." [PMID:26863196, PMID:26863410]
synonym: "RNA N(1)-methyladenosine dioxygenase activity" RELATED []
synonym: "RNA N1-methyladenosine dioxygenase activity" RELATED []
xref: EC:1.14.11.54
xref: RHEA:49516
is_a: GO:0035515 ! oxidative RNA demethylase activity

[Term]
id: GO:1990931
name: mRNA N6-methyladenosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde." [PMID:22002720, PMID:26458103]
synonym: "mRNA N(6)-methyladenine demethylase" EXACT []
synonym: "mRNA N(6)-methyladenosine dioxygenase activity" EXACT []
synonym: "RNA N6-methyladenosine dioxygenase activity" RELATED []
xref: EC:1.14.11.53
xref: RHEA:49520
is_a: GO:0035515 ! oxidative RNA demethylase activity

[Term]
id: GO:1990932
name: 5.8S rRNA binding
namespace: molecular_function
def: "Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA." [PMID:11716358, PMID:15527424]
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:1990933
name: microtubule cytoskeleton attachment to nuclear envelope
namespace: biological_process
def: "A process in which the microtubule cytoskeleton is attached to the nuclear envelope." [PMID:14655046, PMID:20507227]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:1990934
name: nucleolus-like body
namespace: cellular_component
def: "A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles." [PMID:26226217, PMID:9021878]
synonym: "compact nucleolus" EXACT []
synonym: "NLB" EXACT []
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:1990935
name: splicing factor binding
namespace: molecular_function
def: "Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA." [PMID:11118435]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:1990936
name: vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079]
synonym: "vascular smooth muscle cell dedifferentiation" EXACT []
is_a: GO:0090678 ! cell dedifferentiation involved in phenotypic switching

[Term]
id: GO:1990937
name: xylan acetylation
namespace: biological_process
def: "The addition of one or more acetyl groups to a xylan molecule." [PMID:26745802]
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:1990938
name: peptidyl-aspartic acid autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein." [GOC:bf, GOC:PARL, PMID:26134396]
subset: gocheck_obsoletion_candidate
synonym: "aspartyl autophosphorylation" EXACT [PMID:26134396]
synonym: "peptidyl-aspartate autophosphorylation" EXACT [GOC:bf]
is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation
is_a: GO:0046777 ! protein autophosphorylation

[Term]
id: GO:1990940
name: obsolete microtubule sliding involved in mitotic spindle elongation
namespace: biological_process
def: "OBSOLETE. The movement of one microtubule along another microtubule involved in mitotic spindle elongation." [PMID:19686686]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990941
name: mitotic spindle kinetochore microtubule
namespace: cellular_component
def: "Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation." [PMID:18256284]
is_a: GO:0005828 ! kinetochore microtubule
is_a: GO:1990498 ! mitotic spindle microtubule

[Term]
id: GO:1990942
name: mitotic metaphase chromosome recapture
namespace: biological_process
alt_id: GO:1905185
def: "A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate." [PMID:18256284]
synonym: "kinetochore retrieval" EXACT []
synonym: "metaphase chromosome retrieval to the spindle pole body" EXACT []
synonym: "microtubule sliding involved in kinetochore retrieval" EXACT [GOC:TermGenie]
synonym: "microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body" EXACT [GOC:TermGenie]
synonym: "microtubule sliding involved in mitotic metaphase chromosome recapture" RELATED []
synonym: "microtubule sliding involved in sister kinetochore recapture" EXACT [GOC:TermGenie]
synonym: "sister kinetochore recapture" EXACT []
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0007080 ! mitotic metaphase chromosome alignment

[Term]
id: GO:1990943
name: mating type region replication fork barrier binding
namespace: molecular_function
def: "Binding to the replication fork barrier found in the mating type region of fission yeast." [PMID:18723894]
synonym: "RTS1 barrier binding" EXACT []
synonym: "RTS1 element binding" EXACT []
is_a: GO:0031634 ! replication fork barrier binding

[Term]
id: GO:1990946
name: meiosis I/meiosis II transition
namespace: biological_process
def: "The cell cycle process in which a cell progresses from meiosis I to meiosis II." [PMID:21389117]
is_a: GO:0044771 ! meiotic cell cycle phase transition

[Term]
id: GO:1990947
name: exit from meiosis
namespace: biological_process
def: "Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half." [PMID:21389117]
synonym: "meiotic exit" EXACT [GOC:dph]
is_a: GO:0044771 ! meiotic cell cycle phase transition

[Term]
id: GO:1990948
name: ubiquitin ligase inhibitor activity
namespace: molecular_function
alt_id: GO:0061637
alt_id: GO:0090645
def: "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117]
synonym: "APC-Cdc20 complex inhibitor activity" NARROW []
synonym: "mitotic anaphase-promoting complex inhibitor activity" NARROW []
is_a: GO:0055105 ! ubiquitin-protein transferase inhibitor activity

[Term]
id: GO:1990949
name: metaphase/anaphase transition of meiosis I
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I." [ISBN:0815316194]
synonym: "first meiotic metaphase/anaphase transition" RELATED []
synonym: "meiosis I metaphase/anaphase transition" EXACT []
is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
is_a: GO:0061982 ! meiosis I cell cycle process

[Term]
id: GO:1990950
name: metaphase/anaphase transition of meiosis II
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II." [ISBN:0815316194]
synonym: "meiosis II metaphase/anaphase transition" EXACT []
synonym: "second meiotic metaphase/anaphase transition" RELATED []
is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
is_a: GO:0061983 ! meiosis II cell cycle process

[Term]
id: GO:1990951
name: obsolete manchette assembly
namespace: biological_process
def: "OBSOLETE. The assembly and organization of the manchette, a tubular array of microtubules, possibly also containing actin filaments, that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990952
name: obsolete manchette disassembly
namespace: biological_process
def: "OBSOLETE. A cellular process that results in the breakdown of a manchette." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "manchette clearance" EXACT []
is_obsolete: true

[Term]
id: GO:1990953
name: intramanchette transport
namespace: biological_process
def: "The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866]
synonym: "IMT" RELATED []
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0098840 ! protein transport along microtubule
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:1990955
name: G-rich single-stranded DNA binding
namespace: molecular_function
def: "Binding to G-rich, single-stranded DNA." [GOC:hjd, PMID:8493094]
is_a: GO:0003697 ! single-stranded DNA binding

[Term]
id: GO:1990956
name: fibroblast chemotaxis
namespace: biological_process
def: "The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph, PMID:8760137]
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:1990957
name: NPHP complex
namespace: cellular_component
def: "A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways." [GOC:cilia, PMID:18337471, PMID:21422230, PMID:21498478, PMID:21555462, PMID:25150219]
comment: Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme.
synonym: "NPHP module" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0035869 ! ciliary transition zone

[Term]
id: GO:1990958
name: obsolete response to thyrotropin-releasing hormone
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [PMID:21382270]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "response to TRH" RELATED []
is_obsolete: true

[Term]
id: GO:1990959
name: eosinophil homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160]
synonym: "eosinocyte homeostasis" EXACT []
synonym: "eosinophilic granulocyte homeostasis" EXACT []
synonym: "eosinophilic leucocyte homeostasis" EXACT []
synonym: "eosinophilic leukocyte homeostasis" EXACT []
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:1990960
name: basophil homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160]
synonym: "basophilic leucocyte homeostasis" EXACT []
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:1990961
name: xenobiotic detoxification by transmembrane export across the plasma membrane
namespace: biological_process
def: "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell." [PMID:28355133]
synonym: "drug transmembrane export" NARROW []
is_a: GO:0046618 ! xenobiotic export from cell
is_a: GO:0140115 ! export across plasma membrane
relationship: part_of GO:0098754 ! detoxification

[Term]
id: GO:1990962
name: xenobiotic transport across blood-brain barrier
namespace: biological_process
def: "The directed movement of a xenobiotic through the blood-brain barrier." [PMID:25053619]
synonym: "drug transport across blood-brain barrier" RELATED []
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0150104 ! transport across blood-brain barrier

[Term]
id: GO:1990963
name: establishment of blood-retinal barrier
namespace: biological_process
def: "Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type." [PMID:25053619]
synonym: "establishment of blood-retina barrier" EXACT []
synonym: "establishment of BRB" RELATED []
is_a: GO:0048468 ! cell development

[Term]
id: GO:1990964
name: actin cytoskeleton-regulatory complex
namespace: cellular_component
def: "A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat." [GOC:bhm, PMID:10594004, PMID:11739778]
comment: An example of this is Pan1 in Saccharomyces cerevisiae (UniProt ID P32521) in PMID:10594004 (inferred from direct assay).
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:1990965
name: cytosylglucuronate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytosylglucuronic acid + H+ = cytosylarabinopyranose + CO2." [GOC:pr, GOC:tb, PMID:23874663]
comment: This enzymatic activity was shown to be involved in the bacterial blasticidin S biosynthetic pathway.
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:1990966
name: ATP generation from poly-ADP-D-ribose
namespace: biological_process
def: "The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257]
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0046034 ! ATP metabolic process

[Term]
id: GO:1990967
name: obsolete multi-organism toxin transport
namespace: biological_process
def: "OBSOLETE. The directed movement of a toxin into, out of or within a cell, or between cells where two or more organisms of the same or different species are involved." [GOC:bf, GOC:PARL, PMID:18191792, PMID:22042847]
comment: This term was obsoleted because there is no evidence that this process exists.
synonym: "typhoid toxin transport" NARROW [PMID:22042847]
is_obsolete: true

[Term]
id: GO:1990968
name: modulation by host of RNA binding by virus
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA." [GOC:bf, GOC:PARL, PMID:25116364]
comment: Note that the bound RNA may originate from the virus or another organism, including the host.
subset: gocheck_do_not_annotate
synonym: "modulation by host of viral protein:RNA interaction" RELATED [GOC:bf]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0044868 ! modulation by host of viral molecular function
is_a: GO:1905214 ! regulation of RNA binding

[Term]
id: GO:1990969
name: obsolete modulation by host of viral RNA-binding transcription factor activity
namespace: biological_process
def: "OBSOLETE. A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor." [GOC:bf, GOC:PARL, PMID:25116364]
comment: This term was obsoleted because it represents a molecular function.
synonym: "modulation by host of viral Tat activity" NARROW [PMID:25116364]
is_obsolete: true

[Term]
id: GO:1990970
name: trans-activation response element binding
namespace: molecular_function
def: "Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter." [GOC:bf, GOC:PARL, PMID:25116364, Wikipedia:Trans-activation_response_element_(TAR)]
synonym: "TAR binding" EXACT [PMID:25116364]
is_a: GO:0070883 ! pre-miRNA binding

[Term]
id: GO:1990971
name: EMILIN complex
namespace: cellular_component
def: "Glycoprotein complex of the C1q/TNF superfamily found in the extracellular matrix (ECM) where it is an important component of the elastic fiber system. A homotrimer that will combine to form supramolecular EMILIN structures." [GOC:bhm, PMID:10821830]
comment: An example of this is EMILIN-1 in human (Q9Y6C2) in PMID:10821830 (inferred from direct assay).
synonym: "Elastic microfibrillar interface 1 complex" NARROW []
synonym: "Elastic microfibrillar interface 2 complex" NARROW []
synonym: "EMILIN-1 complex" NARROW []
synonym: "EMILIN-2 complex" NARROW []
is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:1990972
name: multimerin complex
namespace: cellular_component
def: "Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures." [GOC:bhm, PMID:9454761]
comment: An example of this is Multimerin-1 in human (Q13201) in PMID:9454761.
synonym: "Elastic microfibrillar interface 3 complex" NARROW []
synonym: "Elastic microfibrillar interface 4 complex" NARROW []
synonym: "EMILIN-3 complex" NARROW []
synonym: "EMILIN-4 complex" NARROW []
synonym: "Multimerin-1 complex" NARROW []
synonym: "Multimerin-2 complex" NARROW []
synonym: "p155 complex" NARROW []
synonym: "Platelet glycoprotein Ia* complex" NARROW []
is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:1990973
name: transmembrane actin-associated (TAN) line
namespace: cellular_component
def: "A linear array of nuclear envelope membrane proteins composed of nesprin-2G and SUN2, which couple the nucleus to moving actin cables, resulting in rearward nuclear transport (away from the leading edge)." [GOC:hjd, PMID:21173262]
synonym: "TAN line" RELATED []
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:1990974
name: actin-dependent nuclear migration
namespace: biological_process
def: "The process whereby the centrosome is held at the cell center while the nucleus moves to the cell rear by actin retrograde flow resulting in the position of the centrosome between the nucleus and the leading edge of the cell." [GOC:hjd, PMID:21173262]
synonym: "actin-dependent nuclear movement" RELATED []
is_a: GO:0007097 ! nuclear migration

[Term]
id: GO:1990976
name: protein transport along microtubule to mitotic spindle pole body
namespace: biological_process
def: "The directed movement of a protein along a microtubule to the mitotic spindle pole body, mediated by motor proteins." [PMID:25987607]
is_a: GO:1902440 ! protein localization to mitotic spindle pole body
is_a: GO:1990852 ! protein transport along microtubule to spindle pole body

[Term]
id: GO:1990977
name: obsolete negative regulation of mitotic DNA replication initiation from late origin
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990978
name: obsolete response to viscosity
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [PMID:7061416]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990979
name: obsolete copper ion transport across blood-brain barrier
namespace: biological_process
def: "OBSOLETE. The directed movement of copper ions passing through the blood-brain barrier." [PMID:24614235]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "copper ion transport across BBB" RELATED []
is_obsolete: true

[Term]
id: GO:1990980
name: obsolete copper ion transport across blood-CSF barrier
namespace: biological_process
def: "OBSOLETE. The directed movement of copper ions passing through the blood-cerebrospinal fluid barrier." [PMID:24614235]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "copper ion transport across BCB" EXACT []
synonym: "copper ion transport across blood-cerebrospinal fluid barrier" EXACT []
is_obsolete: true

[Term]
id: GO:1990981
name: obsolete regulation of protein localization to cell division site involved in cell separation after cytokinesis
namespace: biological_process
def: "OBSOLETE. A regulation of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990982
name: obsolete Immune memory response
namespace: biological_process
def: "OBSOLETE. The immune response against a previously encountered antigen being quicker and quantitatively better compared with the primary response." [PMID:26831526]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990983
name: regulation of translational initiation by tRNA modification
namespace: biological_process
def: "A process in which translation initiation is regulated by post-translation modifications of a tRNA molecule." [PMID:27745969]
synonym: "tRNA demethylation" BROAD []
is_a: GO:0006400 ! tRNA modification
is_a: GO:0006446 ! regulation of translational initiation

[Term]
id: GO:1990984
name: tRNA demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule." [PMID:27745969]
is_a: GO:0035515 ! oxidative RNA demethylase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:1990985
name: obsolete apoptosis in response to oxidative stress
namespace: biological_process
def: "OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to oxidative stress." [GOC:pg, PMID:25950479]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true

[Term]
id: GO:1990986
name: DNA recombinase disassembly
namespace: biological_process
def: "The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases)." [GOC:pg, PMID:19540122]
synonym: "Rad51 nucleoprotein filament disassembly" RELATED []
is_a: GO:0032986 ! protein-DNA complex disassembly

[Term]
id: GO:2000001
name: regulation of DNA damage checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]
synonym: "regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1901976 ! regulation of cell cycle checkpoint
relationship: regulates GO:0000077 ! DNA damage checkpoint signaling

[Term]
id: GO:2000002
name: negative regulation of DNA damage checkpoint
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint." [GOC:BHF, GOC:obol]
synonym: "negative regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol]
is_a: GO:1901977 ! negative regulation of cell cycle checkpoint
is_a: GO:2000001 ! regulation of DNA damage checkpoint
relationship: negatively_regulates GO:0000077 ! DNA damage checkpoint signaling

[Term]
id: GO:2000003
name: positive regulation of DNA damage checkpoint
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]
synonym: "positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol]
is_a: GO:1901978 ! positive regulation of cell cycle checkpoint
is_a: GO:2000001 ! regulation of DNA damage checkpoint
relationship: positively_regulates GO:0000077 ! DNA damage checkpoint signaling

[Term]
id: GO:2000004
name: regulation of metanephric S-shaped body morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0072284 ! metanephric S-shaped body morphogenesis

[Term]
id: GO:2000005
name: negative regulation of metanephric S-shaped body morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000004 ! regulation of metanephric S-shaped body morphogenesis
relationship: negatively_regulates GO:0072284 ! metanephric S-shaped body morphogenesis

[Term]
id: GO:2000006
name: regulation of metanephric comma-shaped body morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0072278 ! metanephric comma-shaped body morphogenesis

[Term]
id: GO:2000007
name: negative regulation of metanephric comma-shaped body morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000006 ! regulation of metanephric comma-shaped body morphogenesis
relationship: negatively_regulates GO:0072278 ! metanephric comma-shaped body morphogenesis

[Term]
id: GO:2000008
name: regulation of protein localization to cell surface
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]
synonym: "regulation of protein localisation at cell surface" EXACT [GOC:mah]
synonym: "regulation of protein localization at cell surface" EXACT []
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0034394 ! protein localization to cell surface

[Term]
id: GO:2000009
name: negative regulation of protein localization to cell surface
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]
synonym: "negative regulation of protein localisation at cell surface" EXACT [GOC:mah]
synonym: "negative regulation of protein localization at cell surface" EXACT []
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:2000008 ! regulation of protein localization to cell surface
relationship: negatively_regulates GO:0034394 ! protein localization to cell surface

[Term]
id: GO:2000010
name: positive regulation of protein localization to cell surface
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]
synonym: "positive regulation of protein localisation at cell surface" EXACT [GOC:mah]
synonym: "positive regulation of protein localization at cell surface" EXACT []
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:2000008 ! regulation of protein localization to cell surface
relationship: positively_regulates GO:0034394 ! protein localization to cell surface

[Term]
id: GO:2000011
name: regulation of adaxial/abaxial pattern formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation." [GOC:obol]
synonym: "regulation of adaxial/abaxial pattern specification" RELATED [GOC:obol]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009955 ! adaxial/abaxial pattern specification

[Term]
id: GO:2000012
name: regulation of auxin polar transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of auxin polar transport." [GOC:obol]
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0009926 ! auxin polar transport

[Term]
id: GO:2000013
name: regulation of arginine biosynthetic process via ornithine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine." [GOC:obol]
synonym: "regulation of arginine anabolism via ornithine" EXACT [GOC:obol]
synonym: "regulation of arginine formation via ornithine" EXACT [GOC:obol]
synonym: "regulation of arginine synthesis via ornithine" EXACT [GOC:obol]
is_a: GO:0000821 ! regulation of arginine metabolic process
is_a: GO:0090368 ! regulation of ornithine metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0042450 ! arginine biosynthetic process via ornithine

[Term]
id: GO:2000014
name: regulation of endosperm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endosperm development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0009960 ! endosperm development

[Term]
id: GO:2000015
name: regulation of determination of dorsal identity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of determination of dorsal identity." [GOC:obol]
synonym: "regulation of determination of adaxial identity" RELATED [GOC:obol]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048263 ! determination of dorsal identity

[Term]
id: GO:2000016
name: negative regulation of determination of dorsal identity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity." [GOC:BHF, GOC:obol]
synonym: "negative regulation of determination of adaxial identity" RELATED [GOC:obol]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000015 ! regulation of determination of dorsal identity
relationship: negatively_regulates GO:0048263 ! determination of dorsal identity

[Term]
id: GO:2000017
name: positive regulation of determination of dorsal identity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of determination of dorsal identity." [GOC:obol]
synonym: "positive regulation of determination of adaxial identity" RELATED [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000015 ! regulation of determination of dorsal identity
relationship: positively_regulates GO:0048263 ! determination of dorsal identity

[Term]
id: GO:2000018
name: regulation of male gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]
synonym: "regulation of testicular development" EXACT [GOC:obol]
synonym: "regulation of testis development" EXACT [GOC:obol]
is_a: GO:1905939 ! regulation of gonad development
relationship: regulates GO:0008584 ! male gonad development

[Term]
id: GO:2000019
name: negative regulation of male gonad development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]
synonym: "negative regulation of testicular development" EXACT [GOC:obol]
synonym: "negative regulation of testis development" EXACT [GOC:obol]
is_a: GO:1905940 ! negative regulation of gonad development
is_a: GO:2000018 ! regulation of male gonad development
relationship: negatively_regulates GO:0008584 ! male gonad development

[Term]
id: GO:2000020
name: positive regulation of male gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol]
synonym: "positive regulation of testicular development" EXACT [GOC:obol]
synonym: "positive regulation of testis development" EXACT [GOC:obol]
is_a: GO:1905941 ! positive regulation of gonad development
is_a: GO:2000018 ! regulation of male gonad development
relationship: positively_regulates GO:0008584 ! male gonad development

[Term]
id: GO:2000022
name: regulation of jasmonic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway." [GOC:obol]
synonym: "regulation of jasmonic acid mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0009867 ! jasmonic acid mediated signaling pathway

[Term]
id: GO:2000023
name: regulation of lateral root development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral root development." [GOC:obol]
is_a: GO:2000069 ! regulation of post-embryonic root development
relationship: regulates GO:0048527 ! lateral root development

[Term]
id: GO:2000024
name: regulation of leaf development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048366 ! leaf development

[Term]
id: GO:2000025
name: regulation of leaf formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf formation." [GOC:obol]
is_a: GO:1905428 ! regulation of plant organ formation
relationship: regulates GO:0010338 ! leaf formation

[Term]
id: GO:2000026
name: regulation of multicellular organismal development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007275 ! multicellular organism development

[Term]
id: GO:2000027
name: regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol]
synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0009887 ! animal organ morphogenesis

[Term]
id: GO:2000028
name: regulation of photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photoperiodism, flowering." [GOC:obol]
synonym: "regulation of photoperiodic control of flowering time" EXACT [GOC:obol]
synonym: "regulation of photoperiodic control of inflorescence development" EXACT [GOC:obol]
synonym: "regulation of response to day length, flowering" EXACT [GOC:obol]
synonym: "regulation of response to night length, flowering" EXACT [GOC:obol]
synonym: "regulation of response to photoperiod, flowering" EXACT [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0048573 ! photoperiodism, flowering

[Term]
id: GO:2000029
name: regulation of proanthocyanidin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process." [GOC:obol]
synonym: "regulation of proanthocyanidin anabolism" EXACT [GOC:obol]
synonym: "regulation of proanthocyanidin biosynthesis" EXACT [GOC:obol]
synonym: "regulation of proanthocyanidin formation" EXACT [GOC:obol]
synonym: "regulation of proanthocyanidin synthesis" EXACT [GOC:obol]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
relationship: regulates GO:0010023 ! proanthocyanidin biosynthetic process

[Term]
id: GO:2000030
name: regulation of response to red or far red light
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to red or far red light." [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009639 ! response to red or far red light

[Term]
id: GO:2000031
name: regulation of salicylic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol]
synonym: "regulation of salicylic acid mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0009863 ! salicylic acid mediated signaling pathway

[Term]
id: GO:2000032
name: regulation of secondary shoot formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary shoot formation." [GOC:obol]
synonym: "regulation of auxiliary shoot formation" RELATED [GOC:obol]
synonym: "regulation of axillary shoot formation" RELATED [GOC:obol]
synonym: "regulation of axillary shoot system formation" EXACT []
synonym: "regulation of shoot branching" RELATED []
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905428 ! regulation of plant organ formation
relationship: regulates GO:0010223 ! secondary shoot formation

[Term]
id: GO:2000033
name: regulation of seed dormancy process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed dormancy process." [GOC:obol, GOC:pr, ISBN:9781405139830]
synonym: "regulation of seed dormancy" RELATED []
is_a: GO:2000034 ! regulation of seed maturation
relationship: regulates GO:0010162 ! seed dormancy process

[Term]
id: GO:2000034
name: regulation of seed maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed maturation." [GOC:obol]
is_a: GO:0080050 ! regulation of seed development
relationship: regulates GO:0010431 ! seed maturation

[Term]
id: GO:2000035
name: regulation of stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol]
synonym: "regulation of stem cell renewal" EXACT [GOC:obol]
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0017145 ! stem cell division

[Term]
id: GO:2000036
name: regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol]
synonym: "regulation of maintenance of pluripotency" RELATED [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0019827 ! stem cell population maintenance

[Term]
id: GO:2000037
name: regulation of stomatal complex patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal complex patterning." [GOC:obol]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0010375 ! stomatal complex patterning

[Term]
id: GO:2000038
name: regulation of stomatal complex development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal complex development." [GOC:obol]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0010374 ! stomatal complex development

[Term]
id: GO:2000039
name: regulation of trichome morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trichome morphogenesis." [GOC:obol]
synonym: "regulation of trichome cell morphogenesis during differentiation" EXACT [GOC:obol]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000024 ! regulation of leaf development
relationship: regulates GO:0010090 ! trichome morphogenesis

[Term]
id: GO:2000040
name: obsolete regulation of planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000041
name: obsolete negative regulation of planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000042
name: negative regulation of double-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw]
synonym: "negative regulation of HDR" EXACT [GOC:obol]
synonym: "negative regulation of homologous recombinational repair" EXACT [GOC:obol]
synonym: "negative regulation of homology-directed repair" EXACT [GOC:obol]
synonym: "negative regulation of HRR" EXACT [GOC:obol]
synonym: "negative regulation of Rad51-dependent recombinational repair" EXACT [GOC:obol]
synonym: "negative regulation of Rhp51-dependent recombinational repair" EXACT [GOC:obol]
is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:2000780 ! negative regulation of double-strand break repair
relationship: negatively_regulates GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:2000043
name: regulation of cardiac cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1905207 ! regulation of cardiocyte differentiation
relationship: regulates GO:0060912 ! cardiac cell fate specification

[Term]
id: GO:2000044
name: negative regulation of cardiac cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF]
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000043 ! regulation of cardiac cell fate specification
relationship: negatively_regulates GO:0060912 ! cardiac cell fate specification

[Term]
id: GO:2000045
name: regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this process is usually achieved by the regulation of the G1 cyclin-dependent protein kinase, consider annotating to the child term 'regulation of cyclin-dependent protein kinase activity involved in G1/S ; GO:0031657'.
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition
relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:2000046
name: obsolete regulation of G2 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:vw]
comment: This term was made obsolete because we felt that phases themselves are not being regulated, it's rather the transitions between phases. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transiition.
synonym: "regulation of G2 phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0010389

[Term]
id: GO:2000047
name: regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0044331 ! cell-cell adhesion mediated by cadherin

[Term]
id: GO:2000048
name: negative regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin
relationship: negatively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin

[Term]
id: GO:2000049
name: positive regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin
relationship: positively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin

[Term]
id: GO:2000050
name: regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf]
synonym: "regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol]
synonym: "regulation of non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
relationship: regulates GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:2000051
name: negative regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf]
synonym: "negative regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
relationship: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:2000052
name: positive regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway." [GOC:obol, GOC:yaf]
synonym: "positive regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
relationship: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:2000053
name: obsolete regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0009950
consider: GO:0030111

[Term]
id: GO:2000054
name: obsolete negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0009950
consider: GO:0030178

[Term]
id: GO:2000055
name: obsolete positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0009950
consider: GO:0030177

[Term]
id: GO:2000056
name: obsolete regulation of Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT []
synonym: "regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling]
is_obsolete: true
consider: GO:0030111
consider: GO:0048546

[Term]
id: GO:2000057
name: obsolete negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0030178
consider: GO:0048546

[Term]
id: GO:2000058
name: regulation of ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol]
synonym: "regulation of protein degradation tagging activity" RELATED [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW []
synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process
relationship: regulates GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:2000059
name: negative regulation of ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]
synonym: "negative regulation of protein degradation tagging activity" BROAD [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [GOC:obol]
synonym: "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW []
synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol]
synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol]
synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol]
synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:1903051 ! negative regulation of proteolysis involved in protein catabolic process
is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process
relationship: negatively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:2000060
name: positive regulation of ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]
synonym: "positive regulation of protein degradation tagging activity" RELATED [GOC:obol]
synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [GOC:obol]
synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [GOC:obol]
synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [GOC:obol]
synonym: "positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW []
synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol]
synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol]
synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol]
synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1903052 ! positive regulation of proteolysis involved in protein catabolic process
is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process
relationship: positively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:2000061
name: regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
relationship: regulates GO:0072193 ! ureter smooth muscle cell differentiation

[Term]
id: GO:2000062
name: negative regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation
relationship: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation

[Term]
id: GO:2000063
name: positive regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation
relationship: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation

[Term]
id: GO:2000064
name: regulation of cortisol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]
synonym: "regulation of cortisol anabolism" RELATED [GOC:obol]
synonym: "regulation of cortisol biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cortisol formation" EXACT [GOC:obol]
synonym: "regulation of cortisol synthesis" EXACT [GOC:obol]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
relationship: regulates GO:0034651 ! cortisol biosynthetic process

[Term]
id: GO:2000065
name: negative regulation of cortisol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]
synonym: "negative regulation of cortisol anabolism" RELATED [GOC:obol]
synonym: "negative regulation of cortisol biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cortisol formation" EXACT [GOC:obol]
synonym: "negative regulation of cortisol synthesis" EXACT [GOC:obol]
is_a: GO:0031947 ! negative regulation of glucocorticoid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
is_a: GO:2000064 ! regulation of cortisol biosynthetic process
relationship: negatively_regulates GO:0034651 ! cortisol biosynthetic process

[Term]
id: GO:2000066
name: positive regulation of cortisol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]
synonym: "positive regulation of cortisol anabolism" RELATED [GOC:obol]
synonym: "positive regulation of cortisol biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cortisol formation" EXACT [GOC:obol]
synonym: "positive regulation of cortisol synthesis" EXACT [GOC:obol]
is_a: GO:0031948 ! positive regulation of glucocorticoid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
is_a: GO:2000064 ! regulation of cortisol biosynthetic process
relationship: positively_regulates GO:0034651 ! cortisol biosynthetic process

[Term]
id: GO:2000067
name: regulation of root morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of root morphogenesis." [GOC:obol]
is_a: GO:1905421 ! regulation of plant organ morphogenesis
relationship: regulates GO:0010015 ! root morphogenesis

[Term]
id: GO:2000068
name: regulation of defense response to insect
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol]
synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0002213 ! defense response to insect

[Term]
id: GO:2000069
name: regulation of post-embryonic root development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-embryonic root development." [GOC:obol]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:2000280 ! regulation of root development
relationship: regulates GO:0048528 ! post-embryonic root development

[Term]
id: GO:2000070
name: regulation of response to water deprivation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol]
synonym: "regulation of drought tolerance" RELATED [GOC:obol]
synonym: "regulation of response to dehydration" EXACT [GOC:obol]
synonym: "regulation of response to drought" EXACT [GOC:obol]
synonym: "regulation of response to thirst" EXACT [GOC:obol]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0009414 ! response to water deprivation

[Term]
id: GO:2000071
name: regulation of defense response by callose deposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response by callose deposition." [GOC:obol]
synonym: "regulation of callose deposition during defense response" RELATED [GOC:obol]
synonym: "regulation of callose localization during defense response" RELATED [GOC:obol]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0052542 ! defense response by callose deposition

[Term]
id: GO:2000073
name: regulation of cytokinesis, site selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "regulation of site selection involved in cell cycle cytokinesis" EXACT []
is_a: GO:0032954 ! regulation of cytokinetic process
relationship: regulates GO:0007105 ! cytokinesis, division site positioning

[Term]
id: GO:2000074
name: regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0003323 ! type B pancreatic cell development

[Term]
id: GO:2000075
name: negative regulation of cytokinesis, site selection
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "negative regulation of site selection involved in cell cycle cytokinesis" EXACT []
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:2000073 ! regulation of cytokinesis, site selection
relationship: negatively_regulates GO:0007105 ! cytokinesis, division site positioning

[Term]
id: GO:2000076
name: positive regulation of cytokinesis, site selection
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "positive regulation of site selection involved in cell cycle cytokinesis" EXACT []
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:2000073 ! regulation of cytokinesis, site selection
relationship: positively_regulates GO:0007105 ! cytokinesis, division site positioning

[Term]
id: GO:2000077
name: negative regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000074 ! regulation of type B pancreatic cell development
relationship: negatively_regulates GO:0003323 ! type B pancreatic cell development

[Term]
id: GO:2000078
name: positive regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000074 ! regulation of type B pancreatic cell development
relationship: positively_regulates GO:0003323 ! type B pancreatic cell development

[Term]
id: GO:2000079
name: obsolete regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT []
synonym: "regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol]
synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0060828
consider: GO:0061469

[Term]
id: GO:2000080
name: obsolete negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT []
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol]
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0061469
consider: GO:0090090

[Term]
id: GO:2000081
name: obsolete positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT []
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol]
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_obsolete: true
consider: GO:0061469
consider: GO:0090263

[Term]
id: GO:2000082
name: regulation of L-ascorbic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407]
synonym: "regulation of ascorbate biosynthesis" EXACT [GOC:obol]
synonym: "regulation of ascorbate biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid anabolism" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid formation" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid synthesis" EXACT [GOC:obol]
synonym: "regulation of vitamin C biosynthesis" EXACT [GOC:obol]
synonym: "regulation of vitamin C biosynthetic process" EXACT [GOC:obol]
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0019853 ! L-ascorbic acid biosynthetic process

[Term]
id: GO:2000083
name: negative regulation of L-ascorbic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407]
synonym: "negative regulation of ascorbate biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of ascorbate biosynthetic process" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid anabolism" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid formation" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid synthesis" EXACT [GOC:obol]
synonym: "negative regulation of vitamin C biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of vitamin C biosynthetic process" EXACT [GOC:obol]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:2000082 ! regulation of L-ascorbic acid biosynthetic process
relationship: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process

[Term]
id: GO:2000084
name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
relationship: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis

[Term]
id: GO:2000085
name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
relationship: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis

[Term]
id: GO:2000086
name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
relationship: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis

[Term]
id: GO:2000087
name: regulation of mesonephric glomerulus development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090192 ! regulation of glomerulus development
relationship: regulates GO:0061224 ! mesonephric glomerulus development

[Term]
id: GO:2000088
name: negative regulation of mesonephric glomerulus development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]
is_a: GO:0090194 ! negative regulation of glomerulus development
is_a: GO:2000087 ! regulation of mesonephric glomerulus development
relationship: negatively_regulates GO:0061224 ! mesonephric glomerulus development

[Term]
id: GO:2000089
name: positive regulation of mesonephric glomerulus development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]
is_a: GO:0090193 ! positive regulation of glomerulus development
is_a: GO:2000087 ! regulation of mesonephric glomerulus development
relationship: positively_regulates GO:0061224 ! mesonephric glomerulus development

[Term]
id: GO:2000090
name: regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
relationship: regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development

[Term]
id: GO:2000091
name: negative regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation
is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation
is_a: GO:2000607 ! negative regulation of cell proliferation involved in mesonephros development
relationship: negatively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development

[Term]
id: GO:2000092
name: positive regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation
is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation
is_a: GO:2000608 ! positive regulation of cell proliferation involved in mesonephros development
relationship: positively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development

[Term]
id: GO:2000093
name: regulation of mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
relationship: regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation

[Term]
id: GO:2000094
name: negative regulation of mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation
is_a: GO:2000093 ! regulation of mesonephric nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation

[Term]
id: GO:2000095
name: regulation of Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF]
synonym: "regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol]
synonym: "regulation of PCP pathway" EXACT [GOC:obol]
synonym: "regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT []
synonym: "regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol]
synonym: "regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling]
synonym: "regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol]
synonym: "regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol]
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
relationship: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway

[Term]
id: GO:2000096
name: positive regulation of Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF]
synonym: "positive regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of PCP pathway" EXACT [GOC:obol]
synonym: "positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol]
synonym: "positive regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling]
synonym: "positive regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol]
is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway
is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway
relationship: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway

[Term]
id: GO:2000097
name: regulation of smooth muscle cell-matrix adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF]
is_a: GO:0001952 ! regulation of cell-matrix adhesion
relationship: regulates GO:0061302 ! smooth muscle cell-matrix adhesion

[Term]
id: GO:2000098
name: negative regulation of smooth muscle cell-matrix adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF]
is_a: GO:0001953 ! negative regulation of cell-matrix adhesion
is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion
relationship: negatively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion

[Term]
id: GO:2000099
name: regulation of establishment or maintenance of bipolar cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity." [GOC:obol]
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
relationship: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity

[Term]
id: GO:2000100
name: regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol]
is_a: GO:2000099 ! regulation of establishment or maintenance of bipolar cell polarity
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
relationship: regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:2000101
name: regulation of mammary stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0002174 ! mammary stem cell proliferation

[Term]
id: GO:2000102
name: negative regulation of mammary stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000101 ! regulation of mammary stem cell proliferation
relationship: negatively_regulates GO:0002174 ! mammary stem cell proliferation

[Term]
id: GO:2000103
name: positive regulation of mammary stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000101 ! regulation of mammary stem cell proliferation
relationship: positively_regulates GO:0002174 ! mammary stem cell proliferation

[Term]
id: GO:2000104
name: negative regulation of DNA-templated DNA replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah]
synonym: "negative regulation of DNA-dependent DNA replication" EXACT []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
relationship: negatively_regulates GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:2000105
name: positive regulation of DNA-templated DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah]
synonym: "positive regulation of DNA-dependent DNA replication" EXACT []
is_a: GO:0045740 ! positive regulation of DNA replication
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
relationship: positively_regulates GO:0006261 ! DNA-templated DNA replication

[Term]
id: GO:2000106
name: regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "regulation of leukocyte apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0071887 ! leukocyte apoptotic process

[Term]
id: GO:2000107
name: negative regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "negative regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
relationship: negatively_regulates GO:0071887 ! leukocyte apoptotic process

[Term]
id: GO:2000108
name: positive regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "positive regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
relationship: positively_regulates GO:0071887 ! leukocyte apoptotic process

[Term]
id: GO:2000109
name: regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "regulation of AICD" RELATED [GOC:yaf]
synonym: "regulation of macrophage apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
relationship: regulates GO:0071888 ! macrophage apoptotic process

[Term]
id: GO:2000110
name: negative regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "negative regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "negative regulation of AICD" RELATED [GOC:yaf]
synonym: "negative regulation of macrophage apoptosis" NARROW []
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
is_a: GO:2000109 ! regulation of macrophage apoptotic process
relationship: negatively_regulates GO:0071888 ! macrophage apoptotic process

[Term]
id: GO:2000111
name: positive regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "positive regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "positive regulation of AICD" RELATED [GOC:yaf]
synonym: "positive regulation of macrophage apoptosis" NARROW []
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
is_a: GO:2000109 ! regulation of macrophage apoptotic process
relationship: positively_regulates GO:0071888 ! macrophage apoptotic process

[Term]
id: GO:2000112
name: obsolete regulation of cellular macromolecule biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]
comment: This term was obsoleted because it is not different from its parent, regulation of macromolecule biosynthetic process ; GO:0010556.
synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol]
is_obsolete: true
replaced_by: GO:0010556

[Term]
id: GO:2000113
name: obsolete negative regulation of cellular macromolecule biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]
comment: This term was obsoleted because it is not different from its parent, negative regulation of macromolecule biosynthetic process ; GO:0010558.
synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol]
is_obsolete: true
replaced_by: GO:0010558

[Term]
id: GO:2000114
name: regulation of establishment of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph]
synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol]
synonym: "regulation of cell polarization" EXACT [GOC:obol]
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
relationship: regulates GO:0030010 ! establishment of cell polarity

[Term]
id: GO:2000115
name: regulation of maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape." [GOC:obol]
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:2000116
name: regulation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]
subset: gocheck_obsoletion_candidate
synonym: "regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol]
synonym: "regulation of thiol endopeptidase activity" EXACT [GOC:obol]
is_a: GO:0052548 ! regulation of endopeptidase activity

[Term]
id: GO:2000117
name: negative regulation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol]
synonym: "negative regulation of thiol endopeptidase activity" EXACT [GOC:obol]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity

[Term]
id: GO:2000118
name: regulation of sodium-dependent phosphate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]
is_a: GO:0010966 ! regulation of phosphate transport
relationship: regulates GO:0044341 ! sodium-dependent phosphate transport

[Term]
id: GO:2000119
name: negative regulation of sodium-dependent phosphate transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport
relationship: negatively_regulates GO:0044341 ! sodium-dependent phosphate transport

[Term]
id: GO:2000120
name: positive regulation of sodium-dependent phosphate transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport
relationship: positively_regulates GO:0044341 ! sodium-dependent phosphate transport

[Term]
id: GO:2000121
name: regulation of removal of superoxide radicals
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of removal of superoxide radicals." [GOC:obol]
synonym: "regulation of removal of O2-" EXACT [GOC:obol]
synonym: "regulation of removal of oxygen free radicals" EXACT [GOC:obol]
is_a: GO:0090322 ! regulation of superoxide metabolic process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1901031 ! regulation of response to reactive oxygen species
relationship: regulates GO:0019430 ! removal of superoxide radicals

[Term]
id: GO:2000122
name: negative regulation of stomatal complex development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development." [GOC:obol]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000038 ! regulation of stomatal complex development
relationship: negatively_regulates GO:0010374 ! stomatal complex development

[Term]
id: GO:2000123
name: positive regulation of stomatal complex development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stomatal complex development." [GOC:obol]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:2000038 ! regulation of stomatal complex development
relationship: positively_regulates GO:0010374 ! stomatal complex development

[Term]
id: GO:2000124
name: regulation of endocannabinoid signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway." [GOC:mah, PMID:15550444]
synonym: "regulation of endocannabinoid signalling pathway" EXACT [GOC:obol]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0071926 ! endocannabinoid signaling pathway

[Term]
id: GO:2000125
name: regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]
synonym: "regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol]
synonym: "regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0007211 ! octopamine or tyramine signaling pathway

[Term]
id: GO:2000126
name: negative regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]
synonym: "negative regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol]
synonym: "negative regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol]
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
relationship: negatively_regulates GO:0007211 ! octopamine or tyramine signaling pathway

[Term]
id: GO:2000127
name: positive regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]
synonym: "positive regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol]
synonym: "positive regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
relationship: positively_regulates GO:0007211 ! octopamine or tyramine signaling pathway

[Term]
id: GO:2000128
name: regulation of octopamine signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]
synonym: "regulation of octopamine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
relationship: regulates GO:0071927 ! octopamine signaling pathway

[Term]
id: GO:2000129
name: negative regulation of octopamine signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]
synonym: "negative regulation of octopamine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway
is_a: GO:2000128 ! regulation of octopamine signaling pathway
relationship: negatively_regulates GO:0071927 ! octopamine signaling pathway

[Term]
id: GO:2000130
name: positive regulation of octopamine signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]
synonym: "positive regulation of octopamine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway
is_a: GO:2000128 ! regulation of octopamine signaling pathway
relationship: positively_regulates GO:0071927 ! octopamine signaling pathway

[Term]
id: GO:2000131
name: regulation of tyramine signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]
synonym: "regulation of tyramine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
relationship: regulates GO:0071928 ! tyramine signaling pathway

[Term]
id: GO:2000132
name: negative regulation of tyramine signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]
synonym: "negative regulation of tyramine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway
is_a: GO:2000131 ! regulation of tyramine signaling pathway
relationship: negatively_regulates GO:0071928 ! tyramine signaling pathway

[Term]
id: GO:2000133
name: positive regulation of tyramine signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]
synonym: "positive regulation of tyramine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway
is_a: GO:2000131 ! regulation of tyramine signaling pathway
relationship: positively_regulates GO:0071928 ! tyramine signaling pathway

[Term]
id: GO:2000134
name: negative regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
is_a: GO:1902807 ! negative regulation of cell cycle G1/S phase transition
is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle
relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:2000135
name: obsolete positive regulation of regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of secondary heart field cardioblast proliferation." [GOC:dph]
comment: This term was made obsolete because it makes no sense and was added in error.
synonym: "positive regulation of regulation of second heart field cardioblast proliferation" EXACT [GOC:obol]
synonym: "positive regulation of regulation of secondary heart field cardioblast proliferation" EXACT []
is_obsolete: true

[Term]
id: GO:2000136
name: regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis

[Term]
id: GO:2000137
name: negative regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
relationship: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis

[Term]
id: GO:2000138
name: positive regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
relationship: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis

[Term]
id: GO:2000139
name: regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]
synonym: "regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:2000128 ! regulation of octopamine signaling pathway
relationship: regulates GO:0071935 ! octopamine signaling pathway involved in response to food

[Term]
id: GO:2000140
name: negative regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]
synonym: "negative regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:0032096 ! negative regulation of response to food
is_a: GO:2000129 ! negative regulation of octopamine signaling pathway
is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food
relationship: negatively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food

[Term]
id: GO:2000141
name: positive regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]
synonym: "positive regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:0032097 ! positive regulation of response to food
is_a: GO:2000130 ! positive regulation of octopamine signaling pathway
is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food
relationship: positively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food

[Term]
id: GO:2000142
name: regulation of DNA-templated transcription initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]
synonym: "regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "regulation of DNA-templated transcription, initiation" EXACT []
synonym: "regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0006355 ! regulation of DNA-templated transcription
relationship: regulates GO:0006352 ! DNA-templated transcription initiation

[Term]
id: GO:2000143
name: negative regulation of DNA-templated transcription initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]
synonym: "negative regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "negative regulation of DNA-templated transcription, initiation" EXACT []
synonym: "negative regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "negative regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0045892 ! negative regulation of DNA-templated transcription
is_a: GO:2000142 ! regulation of DNA-templated transcription initiation
relationship: negatively_regulates GO:0006352 ! DNA-templated transcription initiation

[Term]
id: GO:2000144
name: positive regulation of DNA-templated transcription initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]
synonym: "positive regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "positive regulation of DNA-templated transcription, initiation" EXACT []
synonym: "positive regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "positive regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2]
synonym: "transactivation" RELATED [PMID:11158542]
synonym: "transcriptional transactivation" RELATED [PMID:11580863]
is_a: GO:0045893 ! positive regulation of DNA-templated transcription
is_a: GO:2000142 ! regulation of DNA-templated transcription initiation
relationship: positively_regulates GO:0006352 ! DNA-templated transcription initiation

[Term]
id: GO:2000145
name: regulation of cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "regulation of cell locomotion" EXACT [GOC:obol]
synonym: "regulation of cell movement" RELATED [GOC:obol]
synonym: "regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0048870 ! cell motility

[Term]
id: GO:2000146
name: negative regulation of cell motility
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "negative regulation of cell locomotion" EXACT [GOC:obol]
synonym: "negative regulation of cell movement" RELATED [GOC:obol]
synonym: "negative regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000145 ! regulation of cell motility
relationship: negatively_regulates GO:0048870 ! cell motility

[Term]
id: GO:2000147
name: positive regulation of cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "positive regulation of cell locomotion" EXACT [GOC:obol]
synonym: "positive regulation of cell movement" RELATED [GOC:obol]
synonym: "positive regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000145 ! regulation of cell motility
relationship: positively_regulates GO:0048870 ! cell motility

[Term]
id: GO:2000148
name: obsolete regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0060412
consider: GO:2000095

[Term]
id: GO:2000149
name: obsolete negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000150
name: obsolete regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0055008
consider: GO:2000095

[Term]
id: GO:2000151
name: obsolete negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000152
name: regulation of ubiquitin-specific protease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "regulation of deubiquitinase activity" EXACT []
synonym: "regulation of UBP" RELATED [GOC:obol]
synonym: "regulation of UCH2" RELATED [GOC:obol]
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:2000153
name: obsolete regulation of flagellar cell motility
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of flagellar cell motility." [GOC:mah]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "regulation of flagellar cell motility" EXACT []
is_obsolete: true
consider: GO:1902019
consider: GO:1902021

[Term]
id: GO:2000154
name: obsolete negative regulation of flagellar cell motility
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of flagellar cell motility." [GOC:mah]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "negative regulation of flagellar cell motility" EXACT []
is_obsolete: true
consider: GO:1902020
consider: GO:1902201

[Term]
id: GO:2000155
name: positive regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl]
synonym: "positive regulation of ciliary cell motility" RELATED []
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000147 ! positive regulation of cell motility
relationship: positively_regulates GO:0060285 ! cilium-dependent cell motility

[Term]
id: GO:2000156
name: regulation of retrograde vesicle-mediated transport, Golgi to ER
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER." [GOC:mah]
synonym: "regulation of cis-Golgi to rough endoplasmic reticulum transport" EXACT [GOC:obol]
synonym: "regulation of cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [GOC:obol]
synonym: "regulation of cis-Golgi to rough ER transport" EXACT [GOC:obol]
synonym: "regulation of cis-Golgi to rough ER vesicle-mediated transport" EXACT [GOC:obol]
synonym: "regulation of retrograde (Golgi to ER) transport" EXACT [GOC:obol]
synonym: "regulation of retrograde transport, Golgi to endoplasmic reticulum" EXACT [GOC:obol]
synonym: "regulation of retrograde transport, Golgi to ER" EXACT [GOC:obol]
synonym: "regulation of retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [GOC:obol]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

[Term]
id: GO:2000157
name: negative regulation of ubiquitin-specific protease activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of deubiquitinase activity" EXACT []
synonym: "negative regulation of ubiquitin hydrolase activity" EXACT [GOC:obol]
synonym: "negative regulation of UBP" RELATED [GOC:obol]
synonym: "negative regulation of UCH2" RELATED [GOC:obol]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity

[Term]
id: GO:2000158
name: positive regulation of ubiquitin-specific protease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of deubiquitinase activity" EXACT []
synonym: "positive regulation of ubiquitin hydrolase activity" EXACT [GOC:obol]
synonym: "positive regulation of UBP" RELATED [GOC:obol]
synonym: "positive regulation of UCH2" RELATED [GOC:obol]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity

[Term]
id: GO:2000159
name: obsolete regulation of planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000160
name: obsolete negative regulation of planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000161
name: obsolete regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0003213
consider: GO:2000095

[Term]
id: GO:2000162
name: obsolete negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0003209
consider: GO:0141113

[Term]
id: GO:2000163
name: obsolete regulation of planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0003151
consider: GO:2000095

[Term]
id: GO:2000164
name: obsolete negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000165
name: obsolete regulation of planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true
consider: GO:0003344
consider: GO:2000095

[Term]
id: GO:2000166
name: obsolete negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000167
name: obsolete regulation of planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000168
name: obsolete negative regulation of planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph]
comment: The reason for obsoletion is that this term should be captured using GO-CAM or extensions.
is_obsolete: true

[Term]
id: GO:2000169
name: regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation

[Term]
id: GO:2000170
name: positive regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation
relationship: positively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation

[Term]
id: GO:2000171
name: negative regulation of dendrite development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0050773 ! regulation of dendrite development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0016358 ! dendrite development

[Term]
id: GO:2000172
name: regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
relationship: regulates GO:0048755 ! branching morphogenesis of a nerve

[Term]
id: GO:2000173
name: negative regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve
relationship: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve

[Term]
id: GO:2000174
name: regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
relationship: regulates GO:0002572 ! pro-T cell differentiation

[Term]
id: GO:2000175
name: negative regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
relationship: negatively_regulates GO:0002572 ! pro-T cell differentiation

[Term]
id: GO:2000176
name: positive regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
relationship: positively_regulates GO:0002572 ! pro-T cell differentiation

[Term]
id: GO:2000177
name: regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0061351 ! neural precursor cell proliferation

[Term]
id: GO:2000178
name: negative regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
relationship: negatively_regulates GO:0061351 ! neural precursor cell proliferation

[Term]
id: GO:2000179
name: positive regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
relationship: positively_regulates GO:0061351 ! neural precursor cell proliferation

[Term]
id: GO:2000180
name: negative regulation of androgen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process." [GOC:dph, GOC:yaf]
synonym: "negative regulation of androgen anabolism" EXACT [GOC:obol]
synonym: "negative regulation of androgen biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of androgen formation" EXACT [GOC:obol]
synonym: "negative regulation of androgen synthesis" EXACT [GOC:obol]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
relationship: negatively_regulates GO:0006702 ! androgen biosynthetic process

[Term]
id: GO:2000181
name: negative regulation of blood vessel morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901343 ! negative regulation of vasculature development
relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:2000182
name: regulation of progesterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]
synonym: "regulation of progesterone anabolism" EXACT [GOC:obol]
synonym: "regulation of progesterone biosynthesis" EXACT [GOC:obol]
synonym: "regulation of progesterone formation" EXACT [GOC:obol]
synonym: "regulation of progesterone synthesis" EXACT [GOC:obol]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0006701 ! progesterone biosynthetic process

[Term]
id: GO:2000183
name: negative regulation of progesterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]
synonym: "negative regulation of progesterone anabolism" EXACT [GOC:obol]
synonym: "negative regulation of progesterone biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of progesterone formation" EXACT [GOC:obol]
synonym: "negative regulation of progesterone synthesis" EXACT [GOC:obol]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000182 ! regulation of progesterone biosynthetic process
relationship: negatively_regulates GO:0006701 ! progesterone biosynthetic process

[Term]
id: GO:2000184
name: positive regulation of progesterone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]
synonym: "positive regulation of progesterone anabolism" EXACT [GOC:obol]
synonym: "positive regulation of progesterone biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of progesterone formation" EXACT [GOC:obol]
synonym: "positive regulation of progesterone synthesis" EXACT [GOC:obol]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2000182 ! regulation of progesterone biosynthetic process
relationship: positively_regulates GO:0006701 ! progesterone biosynthetic process

[Term]
id: GO:2000185
name: regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "regulation of phosphate membrane transport" EXACT []
is_a: GO:0010966 ! regulation of phosphate transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
relationship: regulates GO:0035435 ! phosphate ion transmembrane transport

[Term]
id: GO:2000186
name: negative regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "negative regulation of phosphate membrane transport" EXACT []
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:2000185 ! regulation of phosphate transmembrane transport
relationship: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport

[Term]
id: GO:2000187
name: positive regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "positive regulation of phosphate membrane transport" EXACT []
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
is_a: GO:2000185 ! regulation of phosphate transmembrane transport
relationship: positively_regulates GO:0035435 ! phosphate ion transmembrane transport

[Term]
id: GO:2000190
name: obsolete negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor." [GOC:BHF]
comment: This term was made obsolete because it makes no sense and was added in error.
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0003713
consider: GO:0004879
consider: GO:0030522

[Term]
id: GO:2000191
name: regulation of fatty acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid transport." [GOC:BHF]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:0015908 ! fatty acid transport

[Term]
id: GO:2000192
name: negative regulation of fatty acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport." [GOC:BHF]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:2000191 ! regulation of fatty acid transport
relationship: negatively_regulates GO:0015908 ! fatty acid transport

[Term]
id: GO:2000193
name: positive regulation of fatty acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid transport." [GOC:BHF]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:2000191 ! regulation of fatty acid transport
relationship: positively_regulates GO:0015908 ! fatty acid transport

[Term]
id: GO:2000194
name: regulation of female gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "regulation of ovarian development" EXACT [GOC:obol]
synonym: "regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: regulates GO:0008585 ! female gonad development

[Term]
id: GO:2000195
name: negative regulation of female gonad development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "negative regulation of ovarian development" EXACT [GOC:obol]
synonym: "negative regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905940 ! negative regulation of gonad development
is_a: GO:2000194 ! regulation of female gonad development
relationship: negatively_regulates GO:0008585 ! female gonad development

[Term]
id: GO:2000196
name: positive regulation of female gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "positive regulation of ovarian development" EXACT [GOC:obol]
synonym: "positive regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905941 ! positive regulation of gonad development
is_a: GO:2000194 ! regulation of female gonad development
relationship: positively_regulates GO:0008585 ! female gonad development

[Term]
id: GO:2000197
name: regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0071166 ! ribonucleoprotein complex localization

[Term]
id: GO:2000198
name: negative regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "negative regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "negative regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "negative regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "negative regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
relationship: negatively_regulates GO:0071166 ! ribonucleoprotein complex localization

[Term]
id: GO:2000199
name: positive regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "positive regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "positive regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "positive regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "positive regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
relationship: positively_regulates GO:0071166 ! ribonucleoprotein complex localization

[Term]
id: GO:2000200
name: regulation of ribosomal subunit export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]
synonym: "regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol]
synonym: "regulation of ribosome export from nucleus" RELATED [GOC:obol]
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
relationship: regulates GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:2000201
name: negative regulation of ribosomal subunit export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]
synonym: "negative regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol]
synonym: "negative regulation of ribosome export from nucleus" RELATED [GOC:obol]
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0090071 ! negative regulation of ribosome biogenesis
is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
relationship: negatively_regulates GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:2000202
name: positive regulation of ribosomal subunit export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]
synonym: "positive regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol]
synonym: "positive regulation of ribosome export from nucleus" RELATED [GOC:obol]
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
relationship: positively_regulates GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:2000203
name: regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]
synonym: "regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
relationship: regulates GO:0000055 ! ribosomal large subunit export from nucleus

[Term]
id: GO:2000204
name: negative regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]
synonym: "negative regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus
is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus
relationship: negatively_regulates GO:0000055 ! ribosomal large subunit export from nucleus

[Term]
id: GO:2000205
name: positive regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]
synonym: "positive regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus
is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus
relationship: positively_regulates GO:0000055 ! ribosomal large subunit export from nucleus

[Term]
id: GO:2000206
name: regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]
synonym: "regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
relationship: regulates GO:0000056 ! ribosomal small subunit export from nucleus

[Term]
id: GO:2000207
name: negative regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]
synonym: "negative regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus
is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus
relationship: negatively_regulates GO:0000056 ! ribosomal small subunit export from nucleus

[Term]
id: GO:2000208
name: positive regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]
synonym: "positive regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus
is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus
relationship: positively_regulates GO:0000056 ! ribosomal small subunit export from nucleus

[Term]
id: GO:2000209
name: regulation of anoikis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anoikis." [GOC:mah]
synonym: "regulation of detachment induced cell death" EXACT [GOC:obol]
synonym: "regulation of suspension induced apoptosis" EXACT [GOC:obol]
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0043276 ! anoikis

[Term]
id: GO:2000210
name: positive regulation of anoikis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anoikis." [GOC:mah]
synonym: "positive regulation of detachment induced cell death" EXACT [GOC:obol]
synonym: "positive regulation of suspension induced apoptosis" EXACT [GOC:obol]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000209 ! regulation of anoikis
relationship: positively_regulates GO:0043276 ! anoikis

[Term]
id: GO:2000211
name: regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
relationship: regulates GO:0006536 ! glutamate metabolic process

[Term]
id: GO:2000212
name: negative regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
relationship: negatively_regulates GO:0006536 ! glutamate metabolic process

[Term]
id: GO:2000213
name: positive regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "positive regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "positive regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "positive regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
relationship: positively_regulates GO:0006536 ! glutamate metabolic process

[Term]
id: GO:2000214
name: regulation of proline metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline metabolic process." [GOC:sl]
synonym: "regulation of proline metabolism" EXACT [GOC:obol]
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
relationship: regulates GO:0006560 ! proline metabolic process

[Term]
id: GO:2000215
name: negative regulation of proline metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." [GOC:sl]
synonym: "negative regulation of proline metabolism" EXACT [GOC:obol]
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000214 ! regulation of proline metabolic process
relationship: negatively_regulates GO:0006560 ! proline metabolic process

[Term]
id: GO:2000216
name: positive regulation of proline metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proline metabolic process." [GOC:sl]
synonym: "positive regulation of proline metabolism" EXACT [GOC:obol]
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2000214 ! regulation of proline metabolic process
relationship: positively_regulates GO:0006560 ! proline metabolic process

[Term]
id: GO:2000217
name: regulation of invasive growth in response to glucose limitation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]
synonym: "regulation of colony morphology" RELATED [GOC:obol]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
relationship: regulates GO:0001403 ! invasive growth in response to glucose limitation

[Term]
id: GO:2000218
name: negative regulation of invasive growth in response to glucose limitation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]
synonym: "negative regulation of colony morphology" RELATED [GOC:obol]
is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation
relationship: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation

[Term]
id: GO:2000219
name: positive regulation of invasive growth in response to glucose limitation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]
synonym: "positive regulation of colony morphology" RELATED [GOC:obol]
is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation
relationship: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation

[Term]
id: GO:2000220
name: regulation of pseudohyphal growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pseudohyphal growth." [GOC:mah]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
relationship: regulates GO:0007124 ! pseudohyphal growth

[Term]
id: GO:2000221
name: negative regulation of pseudohyphal growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth." [GOC:mah]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000220 ! regulation of pseudohyphal growth
relationship: negatively_regulates GO:0007124 ! pseudohyphal growth

[Term]
id: GO:2000222
name: positive regulation of pseudohyphal growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth." [GOC:mah]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000220 ! regulation of pseudohyphal growth
relationship: positively_regulates GO:0007124 ! pseudohyphal growth

[Term]
id: GO:2000223
name: obsolete regulation of BMP signaling pathway involved in heart jogging
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of BMP signalling pathway involved in heart jogging pathway involved in somitogenesis" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0003146
consider: GO:0030510

[Term]
id: GO:2000224
name: regulation of testosterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0061370 ! testosterone biosynthetic process

[Term]
id: GO:2000225
name: negative regulation of testosterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000224 ! regulation of testosterone biosynthetic process
relationship: negatively_regulates GO:0061370 ! testosterone biosynthetic process

[Term]
id: GO:2000226
name: regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0003310 ! pancreatic A cell differentiation

[Term]
id: GO:2000227
name: negative regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000226 ! regulation of pancreatic A cell differentiation
relationship: negatively_regulates GO:0003310 ! pancreatic A cell differentiation

[Term]
id: GO:2000228
name: positive regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000226 ! regulation of pancreatic A cell differentiation
relationship: positively_regulates GO:0003310 ! pancreatic A cell differentiation

[Term]
id: GO:2000229
name: regulation of pancreatic stellate cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]
is_a: GO:0048145 ! regulation of fibroblast proliferation
relationship: regulates GO:0072343 ! pancreatic stellate cell proliferation

[Term]
id: GO:2000230
name: negative regulation of pancreatic stellate cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]
is_a: GO:0048147 ! negative regulation of fibroblast proliferation
is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation
relationship: negatively_regulates GO:0072343 ! pancreatic stellate cell proliferation

[Term]
id: GO:2000231
name: positive regulation of pancreatic stellate cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]
is_a: GO:0048146 ! positive regulation of fibroblast proliferation
is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation
relationship: positively_regulates GO:0072343 ! pancreatic stellate cell proliferation

[Term]
id: GO:2000232
name: regulation of rRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rRNA processing." [GOC:mah]
synonym: "regulation of 35S primary transcript processing" RELATED [GOC:obol]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0006364 ! rRNA processing

[Term]
id: GO:2000233
name: negative regulation of rRNA processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing." [GOC:mah]
synonym: "negative regulation of 35S primary transcript processing" RELATED [GOC:obol]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:0090071 ! negative regulation of ribosome biogenesis
is_a: GO:2000232 ! regulation of rRNA processing
relationship: negatively_regulates GO:0006364 ! rRNA processing

[Term]
id: GO:2000234
name: positive regulation of rRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah]
synonym: "positive regulation of 35S primary transcript processing" RELATED [GOC:obol]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:2000232 ! regulation of rRNA processing
relationship: positively_regulates GO:0006364 ! rRNA processing

[Term]
id: GO:2000235
name: regulation of tRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA processing." [GOC:mah]
synonym: "regulation of tRNA maturation" EXACT [GOC:obol]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903326 ! regulation of tRNA metabolic process
relationship: regulates GO:0008033 ! tRNA processing

[Term]
id: GO:2000236
name: negative regulation of tRNA processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing." [GOC:mah]
synonym: "negative regulation of tRNA maturation" EXACT [GOC:obol]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:1903327 ! negative regulation of tRNA metabolic process
is_a: GO:2000235 ! regulation of tRNA processing
relationship: negatively_regulates GO:0008033 ! tRNA processing

[Term]
id: GO:2000237
name: positive regulation of tRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA processing." [GOC:mah]
synonym: "positive regulation of tRNA maturation" EXACT [GOC:obol]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:1903328 ! positive regulation of tRNA metabolic process
is_a: GO:2000235 ! regulation of tRNA processing
relationship: positively_regulates GO:0008033 ! tRNA processing

[Term]
id: GO:2000238
name: regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046831 ! regulation of RNA export from nucleus
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
relationship: regulates GO:0006409 ! tRNA export from nucleus

[Term]
id: GO:2000239
name: negative regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "negative regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046832 ! negative regulation of RNA export from nucleus
is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization
is_a: GO:2000238 ! regulation of tRNA export from nucleus
relationship: negatively_regulates GO:0006409 ! tRNA export from nucleus

[Term]
id: GO:2000240
name: positive regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "positive regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046833 ! positive regulation of RNA export from nucleus
is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization
is_a: GO:2000238 ! regulation of tRNA export from nucleus
relationship: positively_regulates GO:0006409 ! tRNA export from nucleus

[Term]
id: GO:2000241
name: regulation of reproductive process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0022414 ! reproductive process

[Term]
id: GO:2000242
name: negative regulation of reproductive process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
relationship: negatively_regulates GO:0022414 ! reproductive process

[Term]
id: GO:2000243
name: positive regulation of reproductive process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
relationship: positively_regulates GO:0022414 ! reproductive process

[Term]
id: GO:2000244
name: regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of FtsZ-dependent cytokinesis." [GOC:mah]
synonym: "regulation of prokaryote-type cytokinesis" RELATED [GOC:obol]
synonym: "regulation of prokaryotic fission" RELATED [GOC:obol]
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0043093 ! FtsZ-dependent cytokinesis

[Term]
id: GO:2000245
name: negative regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah]
synonym: "negative regulation of prokaryote-type cytokinesis" RELATED [GOC:obol]
synonym: "negative regulation of prokaryotic fission" RELATED [GOC:obol]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:2000242 ! negative regulation of reproductive process
is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis
relationship: negatively_regulates GO:0043093 ! FtsZ-dependent cytokinesis

[Term]
id: GO:2000246
name: positive regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah]
synonym: "positive regulation of prokaryote-type cytokinesis" RELATED [GOC:obol]
synonym: "positive regulation of prokaryotic fission" RELATED [GOC:obol]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis
relationship: positively_regulates GO:0043093 ! FtsZ-dependent cytokinesis

[Term]
id: GO:2000247
name: positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol]
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape
relationship: positively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:2000248
name: negative regulation of establishment or maintenance of neuroblast polarity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol]
synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
is_a: GO:0045769 ! negative regulation of asymmetric cell division
relationship: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity

[Term]
id: GO:2000249
name: obsolete regulation of actin cytoskeleton reorganization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]
comment: This term was obsoleted because it represents the same process as regulation of actin cytoskeleton organization ; GO:0032956.
synonym: "regulation of actin cytoskeleton remodeling" EXACT [GOC:obol]
synonym: "regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol]
is_obsolete: true
replaced_by: GO:0032956

[Term]
id: GO:2000250
name: obsolete negative regulation of actin cytoskeleton reorganization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]
comment: This term was obsoleted because it represents the same process as regulation of actin cytoskeleton organization ; GO:0032956.
synonym: "negative regulation of actin cytoskeleton remodeling" EXACT [GOC:obol]
synonym: "negative regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0032956

[Term]
id: GO:2000251
name: obsolete positive regulation of actin cytoskeleton reorganization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]
comment: This term was obsoleted because it represents the same process as regulation of actin cytoskeleton organization ; GO:0032956.
synonym: "positive regulation of actin cytoskeleton remodeling" EXACT [GOC:obol]
synonym: "positive regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0032956

[Term]
id: GO:2000252
name: negative regulation of feeding behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol]
synonym: "negative regulation of behavioral response to food" EXACT [GOC:obol]
synonym: "negative regulation of behavioural response to food" EXACT [GOC:obol]
synonym: "negative regulation of drinking" RELATED [GOC:obol]
synonym: "negative regulation of eating" RELATED [GOC:obol]
synonym: "negative regulation of feeding behaviour" EXACT [GOC:obol]
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0060259 ! regulation of feeding behavior
relationship: negatively_regulates GO:0007631 ! feeding behavior

[Term]
id: GO:2000253
name: positive regulation of feeding behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
synonym: "positive regulation of behavioral response to food" EXACT [GOC:obol]
synonym: "positive regulation of behavioural response to food" EXACT [GOC:obol]
synonym: "positive regulation of drinking" RELATED [GOC:obol]
synonym: "positive regulation of eating" RELATED [GOC:obol]
synonym: "positive regulation of feeding behaviour" EXACT [GOC:obol]
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0060259 ! regulation of feeding behavior
relationship: positively_regulates GO:0007631 ! feeding behavior

[Term]
id: GO:2000254
name: regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:1905936 ! regulation of germ cell proliferation
relationship: regulates GO:0002176 ! male germ cell proliferation

[Term]
id: GO:2000255
name: negative regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:1905937 ! negative regulation of germ cell proliferation
is_a: GO:2000242 ! negative regulation of reproductive process
is_a: GO:2000254 ! regulation of male germ cell proliferation
relationship: negatively_regulates GO:0002176 ! male germ cell proliferation

[Term]
id: GO:2000256
name: positive regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:1905938 ! positive regulation of germ cell proliferation
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2000254 ! regulation of male germ cell proliferation
relationship: positively_regulates GO:0002176 ! male germ cell proliferation

[Term]
id: GO:2000257
name: regulation of protein activation cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah]
synonym: "regulation of protein activation pathway" EXACT [GOC:obol]
synonym: "regulation of protein activitory cascade" EXACT [GOC:obol]
is_a: GO:1903317 ! regulation of protein maturation
relationship: regulates GO:0072376 ! protein activation cascade

[Term]
id: GO:2000258
name: negative regulation of protein activation cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." [GOC:mah]
synonym: "negative regulation of protein activation pathway" EXACT [GOC:obol]
synonym: "negative regulation of protein activitory cascade" EXACT [GOC:obol]
is_a: GO:1903318 ! negative regulation of protein maturation
is_a: GO:2000257 ! regulation of protein activation cascade
relationship: negatively_regulates GO:0072376 ! protein activation cascade

[Term]
id: GO:2000259
name: positive regulation of protein activation cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein activation cascade." [GOC:mah]
synonym: "positive regulation of protein activation pathway" EXACT [GOC:obol]
synonym: "positive regulation of protein activitory cascade" EXACT [GOC:obol]
is_a: GO:1903319 ! positive regulation of protein maturation
is_a: GO:2000257 ! regulation of protein activation cascade
relationship: positively_regulates GO:0072376 ! protein activation cascade

[Term]
id: GO:2000260
name: regulation of blood coagulation, common pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:2000257 ! regulation of protein activation cascade
relationship: regulates GO:0072377 ! blood coagulation, common pathway

[Term]
id: GO:2000261
name: negative regulation of blood coagulation, common pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:2000258 ! negative regulation of protein activation cascade
is_a: GO:2000260 ! regulation of blood coagulation, common pathway
relationship: negatively_regulates GO:0072377 ! blood coagulation, common pathway

[Term]
id: GO:2000262
name: positive regulation of blood coagulation, common pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:2000259 ! positive regulation of protein activation cascade
is_a: GO:2000260 ! regulation of blood coagulation, common pathway
relationship: positively_regulates GO:0072377 ! blood coagulation, common pathway

[Term]
id: GO:2000263
name: regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:2000257 ! regulation of protein activation cascade
relationship: regulates GO:0007598 ! blood coagulation, extrinsic pathway

[Term]
id: GO:2000264
name: negative regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:2000258 ! negative regulation of protein activation cascade
is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway
relationship: negatively_regulates GO:0007598 ! blood coagulation, extrinsic pathway

[Term]
id: GO:2000265
name: positive regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:2000259 ! positive regulation of protein activation cascade
is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway
relationship: positively_regulates GO:0007598 ! blood coagulation, extrinsic pathway

[Term]
id: GO:2000266
name: regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:2000257 ! regulation of protein activation cascade
relationship: regulates GO:0007597 ! blood coagulation, intrinsic pathway

[Term]
id: GO:2000267
name: negative regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:2000258 ! negative regulation of protein activation cascade
is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway
relationship: negatively_regulates GO:0007597 ! blood coagulation, intrinsic pathway

[Term]
id: GO:2000268
name: positive regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:2000259 ! positive regulation of protein activation cascade
is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway
relationship: positively_regulates GO:0007597 ! blood coagulation, intrinsic pathway

[Term]
id: GO:2000269
name: regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "regulation of fibroblast apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0044346 ! fibroblast apoptotic process

[Term]
id: GO:2000270
name: negative regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "negative regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
relationship: negatively_regulates GO:0044346 ! fibroblast apoptotic process

[Term]
id: GO:2000271
name: positive regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "positive regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
relationship: positively_regulates GO:0044346 ! fibroblast apoptotic process

[Term]
id: GO:2000272
name: negative regulation of signaling receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of receptor activity" BROAD []
synonym: "negative regulation of signalling receptor activity" EXACT []
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:0044092 ! negative regulation of molecular function

[Term]
id: GO:2000273
name: positive regulation of signaling receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling receptor activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of signalling receptor activity" EXACT []
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:0044093 ! positive regulation of molecular function

[Term]
id: GO:2000274
name: regulation of epithelial cell migration, open tracheal system
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]
synonym: "regulation of tracheal cell migration" RELATED [GOC:obol]
synonym: "regulation of tracheal epithelial cell migration" RELATED [GOC:obol]
is_a: GO:0010632 ! regulation of epithelial cell migration
relationship: regulates GO:0007427 ! epithelial cell migration, open tracheal system

[Term]
id: GO:2000275
name: regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol]
synonym: "regulation of uncoupling protein activity" RELATED [GOC:obol]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0022898 ! regulation of transmembrane transporter activity

[Term]
id: GO:2000276
name: negative regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol]
synonym: "negative regulation of uncoupling protein activity" RELATED [GOC:obol]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity

[Term]
id: GO:2000277
name: positive regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol]
synonym: "positive regulation of uncoupling protein activity" RELATED [GOC:obol]
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity

[Term]
id: GO:2000278
name: regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "regulation of DNA formation" EXACT [GOC:obol]
synonym: "regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:2000279
name: negative regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of DNA formation" EXACT [GOC:obol]
synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:2000280
name: regulation of root development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of root development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048364 ! root development

[Term]
id: GO:2000281
name: obsolete regulation of histone H3-T3 phosphorylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation." [GOC:obol]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0030291

[Term]
id: GO:2000282
name: regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0008652 ! amino acid biosynthetic process

[Term]
id: GO:2000283
name: negative regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process." [GOC:obol]
synonym: "negative regulation of amino acid anabolism" EXACT [GOC:obol]
synonym: "negative regulation of amino acid biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of amino acid formation" EXACT [GOC:obol]
synonym: "negative regulation of amino acid synthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: negatively_regulates GO:0008652 ! amino acid biosynthetic process

[Term]
id: GO:2000284
name: positive regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "positive regulation of amino acid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of amino acid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of amino acid formation" EXACT [GOC:obol]
synonym: "positive regulation of amino acid synthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: positively_regulates GO:0008652 ! amino acid biosynthetic process

[Term]
id: GO:2000285
name: obsolete negative regulation of regulation of excitatory postsynaptic membrane potential
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of excitatory postsynaptic membrane potential." [GOC:BHF]
comment: This term was made obsolete because it makes no sense and was added in error.
synonym: "negative regulation of EPSP" RELATED [GOC:obol]
synonym: "negative regulation of regulation of excitatory postsynaptic membrane potential" EXACT []
is_obsolete: true
replaced_by: GO:0090394

[Term]
id: GO:2000286
name: obsolete receptor internalization involved in canonical Wnt signaling pathway
namespace: biological_process
def: "OBSOLETE. A receptor internalization process that contributes to canonical Wnt signaling pathway." [GOC:BHF, GOC:mah, PMID:16890161]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "receptor internalization involved in canonical Wnt receptor signaling pathway" EXACT []
synonym: "receptor internalization involved in canonical Wnt receptor signalling pathway" EXACT [GOC:obol]
synonym: "receptor internalization involved in canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "receptor internalization involved in frizzled-1 receptor signaling pathway" RELATED [GOC:obol]
synonym: "receptor internalization involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:obol]
synonym: "receptor internalization involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:obol]
synonym: "receptor internalization involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:obol]
is_obsolete: true
replaced_by: GO:0060070

[Term]
id: GO:2000287
name: positive regulation of myotome development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000290 ! regulation of myotome development
relationship: positively_regulates GO:0061055 ! myotome development

[Term]
id: GO:2000288
name: positive regulation of myoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
relationship: positively_regulates GO:0051450 ! myoblast proliferation

[Term]
id: GO:2000289
name: regulation of photoreceptor cell axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah]
synonym: "regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol]
is_a: GO:1902667 ! regulation of axon guidance
relationship: regulates GO:0072499 ! photoreceptor cell axon guidance

[Term]
id: GO:2000290
name: regulation of myotome development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0061055 ! myotome development

[Term]
id: GO:2000291
name: regulation of myoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0051450 ! myoblast proliferation

[Term]
id: GO:2000292
name: regulation of defecation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0044062 ! regulation of excretion
relationship: regulates GO:0030421 ! defecation

[Term]
id: GO:2000293
name: negative regulation of defecation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:2000292 ! regulation of defecation
relationship: negatively_regulates GO:0030421 ! defecation

[Term]
id: GO:2000294
name: positive regulation of defecation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:2000292 ! regulation of defecation
relationship: positively_regulates GO:0030421 ! defecation

[Term]
id: GO:2000295
name: regulation of hydrogen peroxide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF]
synonym: "regulation of detoxification of H2O2" RELATED [GOC:obol]
synonym: "regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol]
synonym: "regulation of H2O2 catabolic process" EXACT [GOC:obol]
synonym: "regulation of H2O2 scavenging" RELATED [GOC:obol]
synonym: "regulation of hydrogen peroxide breakdown" EXACT [GOC:obol]
synonym: "regulation of hydrogen peroxide catabolism" EXACT [GOC:obol]
synonym: "regulation of hydrogen peroxide degradation" EXACT [GOC:obol]
synonym: "regulation of hydrogen peroxide removal" RELATED [GOC:obol]
synonym: "regulation of hydrogen peroxide scavenging" RELATED [GOC:obol]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
relationship: regulates GO:0042744 ! hydrogen peroxide catabolic process

[Term]
id: GO:2000296
name: negative regulation of hydrogen peroxide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF]
synonym: "negative regulation of detoxification of H2O2" RELATED [GOC:obol]
synonym: "negative regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol]
synonym: "negative regulation of H2O2 catabolic process" EXACT [GOC:obol]
synonym: "negative regulation of H2O2 scavenging" RELATED [GOC:obol]
synonym: "negative regulation of hydrogen peroxide breakdown" EXACT [GOC:obol]
synonym: "negative regulation of hydrogen peroxide catabolism" EXACT [GOC:obol]
synonym: "negative regulation of hydrogen peroxide degradation" EXACT [GOC:obol]
synonym: "negative regulation of hydrogen peroxide removal" RELATED [GOC:obol]
synonym: "negative regulation of hydrogen peroxide scavenging" RELATED [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process
is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process
relationship: negatively_regulates GO:0042744 ! hydrogen peroxide catabolic process

[Term]
id: GO:2000297
name: negative regulation of synapse maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation." [GOC:mah]
synonym: "negative regulation of synaptic maturation" EXACT [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0090128 ! regulation of synapse maturation
is_a: GO:1905809 ! negative regulation of synapse organization
relationship: negatively_regulates GO:0060074 ! synapse maturation

[Term]
id: GO:2000298
name: regulation of Rho-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of Rho-associated protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of ROCK kinase activity" EXACT [GOC:obol]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:2000299
name: negative regulation of Rho-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of Rho-associated protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of ROCK kinase activity" EXACT [GOC:obol]
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
is_a: GO:2000298 ! regulation of Rho-dependent protein serine/threonine kinase activity

[Term]
id: GO:2000300
name: regulation of synaptic vesicle exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]
subset: goslim_synapse
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:1903305 ! regulation of regulated secretory pathway
relationship: regulates GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:2000301
name: negative regulation of synaptic vesicle exocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]
is_a: GO:1903306 ! negative regulation of regulated secretory pathway
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
relationship: negatively_regulates GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:2000302
name: positive regulation of synaptic vesicle exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:1903307 ! positive regulation of regulated secretory pathway
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
relationship: positively_regulates GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:2000303
name: regulation of ceramide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph]
synonym: "regulation of ceramide anabolism" EXACT [GOC:obol]
synonym: "regulation of ceramide biosynthesis" EXACT [GOC:obol]
synonym: "regulation of ceramide formation" EXACT [GOC:obol]
synonym: "regulation of ceramide synthesis" EXACT [GOC:obol]
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
relationship: regulates GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:2000304
name: positive regulation of ceramide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph]
synonym: "positive regulation of ceramide anabolism" EXACT [GOC:obol]
synonym: "positive regulation of ceramide biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of ceramide formation" EXACT [GOC:obol]
synonym: "positive regulation of ceramide synthesis" EXACT [GOC:obol]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0090154 ! positive regulation of sphingolipid biosynthetic process
is_a: GO:2000303 ! regulation of ceramide biosynthetic process
relationship: positively_regulates GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:2000305
name: semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol]
synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol]
synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol]
synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol]
synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol]
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
relationship: part_of GO:2000289 ! regulation of photoreceptor cell axon guidance

[Term]
id: GO:2000306
name: positive regulation of photomorphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of photomorphogenesis." [GOC:obol]
synonym: "positive regulation of plant development in response to light" EXACT [GOC:obol]
is_a: GO:0010099 ! regulation of photomorphogenesis
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009640 ! photomorphogenesis

[Term]
id: GO:2000307
name: regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]
synonym: "regulation of RANKL production" EXACT [GOC:obol]
synonym: "regulation of TNFSF11 production" EXACT [GOC:obol]
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
relationship: regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production

[Term]
id: GO:2000308
name: negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]
synonym: "negative regulation of RANKL production" EXACT [GOC:obol]
synonym: "negative regulation of TNFSF11 production" EXACT [GOC:obol]
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production
relationship: negatively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production

[Term]
id: GO:2000309
name: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]
synonym: "positive regulation of RANKL production" EXACT [GOC:obol]
synonym: "positive regulation of TNFSF11 production" EXACT [GOC:obol]
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production
relationship: positively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production

[Term]
id: GO:2000310
name: regulation of NMDA receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT []
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity

[Term]
id: GO:2000311
name: regulation of AMPA receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT []
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity

[Term]
id: GO:2000312
name: regulation of kainate selective glutamate receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:2000313
name: regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]
synonym: "regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol]
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
relationship: regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

[Term]
id: GO:2000314
name: negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]
synonym: "negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol]
is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
relationship: negatively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

[Term]
id: GO:2000315
name: positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]
synonym: "positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol]
is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
relationship: positively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

[Term]
id: GO:2000316
name: regulation of T-helper 17 type immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]
synonym: "regulation of Th17 immune response" EXACT [GOC:obol]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0072538 ! T-helper 17 type immune response

[Term]
id: GO:2000317
name: negative regulation of T-helper 17 type immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]
synonym: "negative regulation of Th17 immune response" EXACT [GOC:obol]
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:2000316 ! regulation of T-helper 17 type immune response
relationship: negatively_regulates GO:0072538 ! T-helper 17 type immune response

[Term]
id: GO:2000318
name: positive regulation of T-helper 17 type immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]
synonym: "positive regulation of Th17 immune response" EXACT [GOC:obol]
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:2000316 ! regulation of T-helper 17 type immune response
relationship: positively_regulates GO:0072538 ! T-helper 17 type immune response

[Term]
id: GO:2000319
name: regulation of T-helper 17 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]
synonym: "regulation of T-helper 17 cell development" RELATED [GOC:obol]
is_a: GO:0045622 ! regulation of T-helper cell differentiation
is_a: GO:2000316 ! regulation of T-helper 17 type immune response
relationship: regulates GO:0072539 ! T-helper 17 cell differentiation

[Term]
id: GO:2000320
name: negative regulation of T-helper 17 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of T-helper 17 cell development" RELATED [GOC:obol]
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:2000317 ! negative regulation of T-helper 17 type immune response
is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation
relationship: negatively_regulates GO:0072539 ! T-helper 17 cell differentiation

[Term]
id: GO:2000321
name: positive regulation of T-helper 17 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of T-helper 17 cell development" RELATED [GOC:obol]
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:2000318 ! positive regulation of T-helper 17 type immune response
is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation
relationship: positively_regulates GO:0072539 ! T-helper 17 cell differentiation

[Term]
id: GO:2000322
name: regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]
synonym: "regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol]
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
relationship: regulates GO:0042921 ! nuclear receptor-mediated glucocorticoid signaling pathway

[Term]
id: GO:2000323
name: negative regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]
synonym: "negative regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol]
is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway
relationship: negatively_regulates GO:0042921 ! nuclear receptor-mediated glucocorticoid signaling pathway

[Term]
id: GO:2000324
name: positive regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]
synonym: "positive regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol]
is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway
relationship: positively_regulates GO:0042921 ! nuclear receptor-mediated glucocorticoid signaling pathway

[Term]
id: GO:2000325
name: obsolete regulation of nuclear receptor coactivator activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol]
synonym: "regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT []
synonym: "regulation of nuclear receptor transcription coactivator activity" EXACT []
is_obsolete: true

[Term]
id: GO:2000326
name: obsolete negative regulation of nuclear receptor transcription coactivator activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol]
synonym: "negative regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT []
is_obsolete: true
consider: GO:0003714

[Term]
id: GO:2000327
name: obsolete positive regulation of nuclear receptor transcription coactivator activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol]
synonym: "positive regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT []
is_obsolete: true
consider: GO:0003713

[Term]
id: GO:2000328
name: regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]
synonym: "regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol]
synonym: "regulation of Th17 cell lineage commitment" EXACT [GOC:obol]
synonym: "regulation of Th17 fate commitment" EXACT [GOC:obol]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation
relationship: regulates GO:0072540 ! T-helper 17 cell lineage commitment

[Term]
id: GO:2000329
name: negative regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]
synonym: "negative regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol]
synonym: "negative regulation of Th17 cell lineage commitment" EXACT [GOC:obol]
synonym: "negative regulation of Th17 fate commitment" EXACT [GOC:obol]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:2000320 ! negative regulation of T-helper 17 cell differentiation
is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment
relationship: negatively_regulates GO:0072540 ! T-helper 17 cell lineage commitment

[Term]
id: GO:2000330
name: positive regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]
synonym: "positive regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol]
synonym: "positive regulation of Th17 cell lineage commitment" EXACT [GOC:obol]
synonym: "positive regulation of Th17 fate commitment" EXACT [GOC:obol]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:2000321 ! positive regulation of T-helper 17 cell differentiation
is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment
relationship: positively_regulates GO:0072540 ! T-helper 17 cell lineage commitment

[Term]
id: GO:2000331
name: regulation of terminal button organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
synonym: "regulation of bouton organization" EXACT [GOC:obol]
synonym: "regulation of presynaptic bouton organization" EXACT [GOC:obol]
synonym: "regulation of synaptic bouton organization" EXACT [GOC:obol]
synonym: "regulation of terminal bouton organization" EXACT [GOC:obol]
synonym: "regulation of terminal button organisation" EXACT [GOC:obol]
is_a: GO:0099174 ! regulation of presynapse organization
relationship: regulates GO:0072553 ! terminal button organization

[Term]
id: GO:2000332
name: regulation of blood microparticle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]
synonym: "regulation of microparticle generation" EXACT [GOC:obol]
synonym: "regulation of microparticle release" EXACT [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0072564 ! blood microparticle formation

[Term]
id: GO:2000333
name: negative regulation of blood microparticle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of microparticle generation" EXACT [GOC:obol]
synonym: "negative regulation of microparticle release" EXACT [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:2000332 ! regulation of blood microparticle formation
relationship: negatively_regulates GO:0072564 ! blood microparticle formation

[Term]
id: GO:2000334
name: positive regulation of blood microparticle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of microparticle generation" EXACT [GOC:obol]
synonym: "positive regulation of microparticle release" EXACT [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:2000332 ! regulation of blood microparticle formation
relationship: positively_regulates GO:0072564 ! blood microparticle formation

[Term]
id: GO:2000335
name: regulation of endothelial microparticle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]
synonym: "regulation of endothelial microparticle generation" EXACT [GOC:obol]
synonym: "regulation of endothelial microparticle release" EXACT [GOC:obol]
is_a: GO:2000332 ! regulation of blood microparticle formation
relationship: regulates GO:0072565 ! endothelial microparticle formation

[Term]
id: GO:2000336
name: negative regulation of endothelial microparticle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of endothelial microparticle generation" EXACT [GOC:obol]
synonym: "negative regulation of endothelial microparticle release" EXACT [GOC:obol]
is_a: GO:2000333 ! negative regulation of blood microparticle formation
is_a: GO:2000335 ! regulation of endothelial microparticle formation
relationship: negatively_regulates GO:0072565 ! endothelial microparticle formation

[Term]
id: GO:2000337
name: positive regulation of endothelial microparticle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of endothelial microparticle generation" EXACT [GOC:obol]
synonym: "positive regulation of endothelial microparticle release" EXACT [GOC:obol]
is_a: GO:2000334 ! positive regulation of blood microparticle formation
is_a: GO:2000335 ! regulation of endothelial microparticle formation
relationship: positively_regulates GO:0072565 ! endothelial microparticle formation

[Term]
id: GO:2000338
name: regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]
synonym: "regulation of CXCL1 production" EXACT [GOC:obol]
synonym: "regulation of KC production" EXACT [GOC:obol]
synonym: "regulation of keratinocyte derived chemokine production" EXACT [GOC:obol]
synonym: "regulation of SCYB1 production" EXACT [GOC:obol]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production

[Term]
id: GO:2000339
name: negative regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]
synonym: "negative regulation of CXCL1 production" EXACT [GOC:obol]
synonym: "negative regulation of KC production" EXACT [GOC:obol]
synonym: "negative regulation of keratinocyte derived chemokine production" EXACT [GOC:obol]
synonym: "negative regulation of SCYB1 production" EXACT [GOC:obol]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production
relationship: negatively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production

[Term]
id: GO:2000340
name: positive regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]
synonym: "positive regulation of CXCL1 production" EXACT [GOC:obol]
synonym: "positive regulation of KC production" EXACT [GOC:obol]
synonym: "positive regulation of keratinocyte derived chemokine production" EXACT [GOC:obol]
synonym: "positive regulation of SCYB1 production" EXACT [GOC:obol]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production
relationship: positively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production

[Term]
id: GO:2000341
name: regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
alt_id: GO:0035926
alt_id: GO:1904207
def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
synonym: "chemokine (C-C motif) ligand 2 secretion" NARROW []
synonym: "regulation of CCL2 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of chemokine (C-C motif) ligand 2 secretion" NARROW []
synonym: "regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "regulation of MIP2 production" EXACT [GOC:obol]
synonym: "regulation of SCYB2 production" EXACT [GOC:obol]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production

[Term]
id: GO:2000342
name: negative regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
alt_id: GO:1904208
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of chemokine (C-C motif) ligand 2 secretion" NARROW []
synonym: "negative regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "negative regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "negative regulation of MIP2 production" EXACT [GOC:obol]
synonym: "negative regulation of SCYB2 production" EXACT [GOC:obol]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production
relationship: negatively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production

[Term]
id: GO:2000343
name: positive regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
alt_id: GO:1904209
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of chemokine (C-C motif) ligand 2 secretion" NARROW []
synonym: "positive regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "positive regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "positive regulation of MIP2 production" EXACT [GOC:obol]
synonym: "positive regulation of SCYB2 production" EXACT [GOC:obol]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production
relationship: positively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production

[Term]
id: GO:2000344
name: positive regulation of acrosome reaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the acrosome reaction." [GOC:obol]
is_a: GO:0060046 ! regulation of acrosome reaction
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0007340 ! acrosome reaction

[Term]
id: GO:2000345
name: regulation of hepatocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0072574 ! hepatocyte proliferation

[Term]
id: GO:2000346
name: negative regulation of hepatocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:2000345 ! regulation of hepatocyte proliferation
relationship: negatively_regulates GO:0072574 ! hepatocyte proliferation

[Term]
id: GO:2000347
name: positive regulation of hepatocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:2000345 ! regulation of hepatocyte proliferation
relationship: positively_regulates GO:0072574 ! hepatocyte proliferation

[Term]
id: GO:2000348
name: regulation of CD40 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:mah]
synonym: "regulation of CD40 signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0023035 ! CD40 signaling pathway

[Term]
id: GO:2000349
name: negative regulation of CD40 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah]
synonym: "negative regulation of CD40 signalling pathway" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2000348 ! regulation of CD40 signaling pathway
relationship: negatively_regulates GO:0023035 ! CD40 signaling pathway

[Term]
id: GO:2000350
name: positive regulation of CD40 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah]
synonym: "positive regulation of CD40 signalling pathway" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2000348 ! regulation of CD40 signaling pathway
relationship: positively_regulates GO:0023035 ! CD40 signaling pathway

[Term]
id: GO:2000351
name: regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of endothelial cell apoptosis" NARROW []
synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0072577 ! endothelial cell apoptotic process

[Term]
id: GO:2000352
name: negative regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of endothelial cell apoptosis" NARROW []
synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
relationship: negatively_regulates GO:0072577 ! endothelial cell apoptotic process

[Term]
id: GO:2000353
name: positive regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of endothelial cell apoptosis" NARROW []
synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
relationship: positively_regulates GO:0072577 ! endothelial cell apoptotic process

[Term]
id: GO:2000354
name: regulation of ovarian follicle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovarian follicle development." [GOC:obol]
synonym: "regulation of follicular phase" RELATED [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0001541 ! ovarian follicle development

[Term]
id: GO:2000355
name: negative regulation of ovarian follicle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development." [GOC:obol]
synonym: "negative regulation of follicular phase" RELATED [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000354 ! regulation of ovarian follicle development
relationship: negatively_regulates GO:0001541 ! ovarian follicle development

[Term]
id: GO:2000356
name: regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
relationship: regulates GO:0072195 ! kidney smooth muscle cell differentiation

[Term]
id: GO:2000357
name: negative regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation
relationship: negatively_regulates GO:0072195 ! kidney smooth muscle cell differentiation

[Term]
id: GO:2000358
name: positive regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation
relationship: positively_regulates GO:0072195 ! kidney smooth muscle cell differentiation

[Term]
id: GO:2000359
name: regulation of binding of sperm to zona pellucida
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol]
synonym: "regulation of ZPG binding" RELATED [GOC:obol]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007339 ! binding of sperm to zona pellucida

[Term]
id: GO:2000360
name: negative regulation of binding of sperm to zona pellucida
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol]
synonym: "negative regulation of ZPG binding" RELATED [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000242 ! negative regulation of reproductive process
is_a: GO:2000359 ! regulation of binding of sperm to zona pellucida
relationship: negatively_regulates GO:0007339 ! binding of sperm to zona pellucida

[Term]
id: GO:2000361
name: regulation of prostaglandin-E synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol]
synonym: "regulation of endoperoxide isomerase activity" EXACT [GOC:obol]
synonym: "regulation of PGE isomerase activity" EXACT [GOC:obol]
synonym: "regulation of PGE2 isomerase activity" EXACT [GOC:obol]
synonym: "regulation of PGH-PGE isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol]
synonym: "regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol]
is_a: GO:0010911 ! regulation of isomerase activity

[Term]
id: GO:2000362
name: obsolete negative regulation of prostaglandin-E synthase activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of endoperoxide isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of PGE isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of PGE2 isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of PGH-PGE isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000363
name: positive regulation of prostaglandin-E synthase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of endoperoxide isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of PGE isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of PGE2 isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of PGH-PGE isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol]
is_a: GO:0010912 ! positive regulation of isomerase activity
is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity

[Term]
id: GO:2000367
name: regulation of acrosomal vesicle exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol]
synonym: "regulation of acrosomal granule exocytosis" RELATED [GOC:obol]
synonym: "regulation of acrosome exocytosis" EXACT [GOC:obol]
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
relationship: regulates GO:0060478 ! acrosomal vesicle exocytosis

[Term]
id: GO:2000368
name: positive regulation of acrosomal vesicle exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol]
synonym: "positive regulation of acrosomal granule exocytosis" RELATED [GOC:obol]
synonym: "positive regulation of acrosome exocytosis" EXACT [GOC:obol]
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2000367 ! regulation of acrosomal vesicle exocytosis
relationship: positively_regulates GO:0060478 ! acrosomal vesicle exocytosis

[Term]
id: GO:2000369
name: regulation of clathrin-dependent endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah]
synonym: "regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol]
synonym: "regulation of clathrin-mediated endocytosis" EXACT []
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
relationship: regulates GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:2000370
name: positive regulation of clathrin-dependent endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:BHF, GOC:mah]
synonym: "positive regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol]
synonym: "positive regulation of clathrin-mediated endocytosis" EXACT []
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
is_a: GO:2000369 ! regulation of clathrin-dependent endocytosis
relationship: positively_regulates GO:0072583 ! clathrin-dependent endocytosis

[Term]
id: GO:2000371
name: regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol]
synonym: "regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol]
synonym: "regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol]
synonym: "regulation of DNA topoisomerase II" RELATED [GOC:obol]
synonym: "regulation of DNA topoisomerase IV activity" EXACT [GOC:obol]
synonym: "regulation of DNA topoisomerase type II activity" EXACT [GOC:obol]
synonym: "regulation of topoisomerase" RELATED [GOC:obol]
synonym: "regulation of topoisomerase II" EXACT [GOC:obol]
synonym: "regulation of type II DNA topoisomerase activity" EXACT [GOC:obol]
is_a: GO:0010911 ! regulation of isomerase activity
is_a: GO:0043462 ! regulation of ATP-dependent activity

[Term]
id: GO:2000372
name: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol]
synonym: "negative regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol]
synonym: "negative regulation of DNA topoisomerase II" RELATED [GOC:obol]
synonym: "negative regulation of DNA topoisomerase IV activity" EXACT [GOC:obol]
synonym: "negative regulation of DNA topoisomerase type II activity" EXACT [GOC:obol]
synonym: "negative regulation of topoisomerase" RELATED [GOC:obol]
synonym: "negative regulation of topoisomerase II" EXACT [GOC:obol]
synonym: "negative regulation of type II DNA topoisomerase activity" EXACT [GOC:obol]
is_a: GO:0032780 ! negative regulation of ATP-dependent activity
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity

[Term]
id: GO:2000373
name: positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol]
synonym: "positive regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol]
synonym: "positive regulation of DNA topoisomerase II" RELATED [GOC:obol]
synonym: "positive regulation of DNA topoisomerase IV activity" EXACT [GOC:obol]
synonym: "positive regulation of DNA topoisomerase type II activity" EXACT [GOC:obol]
synonym: "positive regulation of topoisomerase" RELATED [GOC:obol]
synonym: "positive regulation of topoisomerase II" EXACT [GOC:obol]
synonym: "positive regulation of type II DNA topoisomerase activity" EXACT [GOC:obol]
is_a: GO:0010912 ! positive regulation of isomerase activity
is_a: GO:0032781 ! positive regulation of ATP-dependent activity
is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity

[Term]
id: GO:2000374
name: regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0072592 ! oxygen metabolic process

[Term]
id: GO:2000375
name: negative regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:2000374 ! regulation of oxygen metabolic process
relationship: negatively_regulates GO:0072592 ! oxygen metabolic process

[Term]
id: GO:2000376
name: positive regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:2000374 ! regulation of oxygen metabolic process
relationship: positively_regulates GO:0072592 ! oxygen metabolic process

[Term]
id: GO:2000377
name: regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:2000378
name: negative regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
relationship: negatively_regulates GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:2000379
name: positive regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
relationship: positively_regulates GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:2000380
name: regulation of mesoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0007498 ! mesoderm development

[Term]
id: GO:2000381
name: negative regulation of mesoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
relationship: negatively_regulates GO:0007498 ! mesoderm development

[Term]
id: GO:2000382
name: positive regulation of mesoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
relationship: positively_regulates GO:0007498 ! mesoderm development

[Term]
id: GO:2000383
name: regulation of ectoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0007398 ! ectoderm development

[Term]
id: GO:2000384
name: negative regulation of ectoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
relationship: negatively_regulates GO:0007398 ! ectoderm development

[Term]
id: GO:2000385
name: positive regulation of ectoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
relationship: positively_regulates GO:0007398 ! ectoderm development

[Term]
id: GO:2000386
name: positive regulation of ovarian follicle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovarian follicle development." [GOC:obol]
synonym: "positive regulation of follicular phase" RELATED [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000354 ! regulation of ovarian follicle development
relationship: positively_regulates GO:0001541 ! ovarian follicle development

[Term]
id: GO:2000387
name: regulation of antral ovarian follicle growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0001547 ! antral ovarian follicle growth

[Term]
id: GO:2000388
name: positive regulation of antral ovarian follicle growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2000387 ! regulation of antral ovarian follicle growth
relationship: positively_regulates GO:0001547 ! antral ovarian follicle growth

[Term]
id: GO:2000389
name: regulation of neutrophil extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil extravasation." [GOC:mah]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:1902622 ! regulation of neutrophil migration
relationship: regulates GO:0072672 ! neutrophil extravasation

[Term]
id: GO:2000390
name: negative regulation of neutrophil extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:1902623 ! negative regulation of neutrophil migration
is_a: GO:2000389 ! regulation of neutrophil extravasation
relationship: negatively_regulates GO:0072672 ! neutrophil extravasation

[Term]
id: GO:2000391
name: positive regulation of neutrophil extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:1902624 ! positive regulation of neutrophil migration
is_a: GO:2000389 ! regulation of neutrophil extravasation
relationship: positively_regulates GO:0072672 ! neutrophil extravasation

[Term]
id: GO:2000392
name: regulation of lamellipodium morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis." [GOC:mah]
synonym: "regulation of lamellipodium organization" RELATED [GOC:obol]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:1902743 ! regulation of lamellipodium organization
relationship: regulates GO:0072673 ! lamellipodium morphogenesis

[Term]
id: GO:2000393
name: negative regulation of lamellipodium morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah]
synonym: "negative regulation of lamellipodium organization" RELATED [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902744 ! negative regulation of lamellipodium organization
is_a: GO:2000392 ! regulation of lamellipodium morphogenesis
relationship: negatively_regulates GO:0072673 ! lamellipodium morphogenesis

[Term]
id: GO:2000394
name: positive regulation of lamellipodium morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah]
synonym: "positive regulation of lamellipodium organization" RELATED [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902745 ! positive regulation of lamellipodium organization
is_a: GO:2000392 ! regulation of lamellipodium morphogenesis
relationship: positively_regulates GO:0072673 ! lamellipodium morphogenesis

[Term]
id: GO:2000395
name: regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]
synonym: "regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol]
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051223 ! regulation of protein transport
relationship: regulates GO:0070086 ! ubiquitin-dependent endocytosis

[Term]
id: GO:2000396
name: negative regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]
synonym: "negative regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol]
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis
relationship: negatively_regulates GO:0070086 ! ubiquitin-dependent endocytosis

[Term]
id: GO:2000397
name: positive regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]
synonym: "positive regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol]
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis
relationship: positively_regulates GO:0070086 ! ubiquitin-dependent endocytosis

[Term]
id: GO:2000398
name: regulation of thymocyte aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thymocyte aggregation." [GOC:mah]
synonym: "regulation of immature T cell aggregation" RELATED [GOC:obol]
synonym: "regulation of immature T-cell aggregation" RELATED [GOC:obol]
synonym: "regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol]
synonym: "regulation of T cell precursor aggregation" EXACT [GOC:obol]
synonym: "regulation of thymic lymphocyte aggregation" EXACT [GOC:obol]
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
relationship: regulates GO:0071594 ! thymocyte aggregation

[Term]
id: GO:2000399
name: negative regulation of thymocyte aggregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of immature T cell aggregation" RELATED [GOC:obol]
synonym: "negative regulation of immature T-cell aggregation" RELATED [GOC:obol]
synonym: "negative regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol]
synonym: "negative regulation of T cell precursor aggregation" EXACT [GOC:obol]
synonym: "negative regulation of thymic lymphocyte aggregation" EXACT [GOC:obol]
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
is_a: GO:2000398 ! regulation of thymocyte aggregation
relationship: negatively_regulates GO:0071594 ! thymocyte aggregation

[Term]
id: GO:2000400
name: positive regulation of thymocyte aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of immature T cell aggregation" RELATED [GOC:obol]
synonym: "positive regulation of immature T-cell aggregation" RELATED [GOC:obol]
synonym: "positive regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol]
synonym: "positive regulation of T cell precursor aggregation" EXACT [GOC:obol]
synonym: "positive regulation of thymic lymphocyte aggregation" EXACT [GOC:obol]
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
is_a: GO:2000398 ! regulation of thymocyte aggregation
relationship: positively_regulates GO:0071594 ! thymocyte aggregation

[Term]
id: GO:2000401
name: regulation of lymphocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: regulates GO:0072676 ! lymphocyte migration

[Term]
id: GO:2000402
name: negative regulation of lymphocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:2000401 ! regulation of lymphocyte migration
relationship: negatively_regulates GO:0072676 ! lymphocyte migration

[Term]
id: GO:2000403
name: positive regulation of lymphocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:2000401 ! regulation of lymphocyte migration
relationship: positively_regulates GO:0072676 ! lymphocyte migration

[Term]
id: GO:2000404
name: regulation of T cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "regulation of T-cell migration" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000401 ! regulation of lymphocyte migration
relationship: regulates GO:0072678 ! T cell migration

[Term]
id: GO:2000405
name: negative regulation of T cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "negative regulation of T-cell migration" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000402 ! negative regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
relationship: negatively_regulates GO:0072678 ! T cell migration

[Term]
id: GO:2000406
name: positive regulation of T cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "positive regulation of T-cell migration" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000403 ! positive regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
relationship: positively_regulates GO:0072678 ! T cell migration

[Term]
id: GO:2000407
name: regulation of T cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell extravasation." [GOC:mah]
synonym: "regulation of T lymphocyte extravasation" EXACT [GOC:obol]
synonym: "regulation of T-cell extravasation" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte extravasation" EXACT [GOC:obol]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:2000404 ! regulation of T cell migration
relationship: regulates GO:0072683 ! T cell extravasation

[Term]
id: GO:2000408
name: negative regulation of T cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of T lymphocyte extravasation" EXACT [GOC:obol]
synonym: "negative regulation of T-cell extravasation" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte extravasation" EXACT [GOC:obol]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:2000405 ! negative regulation of T cell migration
is_a: GO:2000407 ! regulation of T cell extravasation
relationship: negatively_regulates GO:0072683 ! T cell extravasation

[Term]
id: GO:2000409
name: positive regulation of T cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of T lymphocyte extravasation" EXACT [GOC:obol]
synonym: "positive regulation of T-cell extravasation" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte extravasation" EXACT [GOC:obol]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:2000406 ! positive regulation of T cell migration
is_a: GO:2000407 ! regulation of T cell extravasation
relationship: positively_regulates GO:0072683 ! T cell extravasation

[Term]
id: GO:2000410
name: regulation of thymocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thymocyte migration." [GOC:mah]
synonym: "regulation of immature T cell migration" RELATED [GOC:obol]
synonym: "regulation of immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of immature T-cell migration" RELATED [GOC:obol]
synonym: "regulation of immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000404 ! regulation of T cell migration
relationship: regulates GO:0072679 ! thymocyte migration

[Term]
id: GO:2000411
name: negative regulation of thymocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration." [GOC:mah]
synonym: "negative regulation of immature T cell migration" RELATED [GOC:obol]
synonym: "negative regulation of immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of immature T-cell migration" RELATED [GOC:obol]
synonym: "negative regulation of immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000405 ! negative regulation of T cell migration
is_a: GO:2000410 ! regulation of thymocyte migration
relationship: negatively_regulates GO:0072679 ! thymocyte migration

[Term]
id: GO:2000412
name: positive regulation of thymocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thymocyte migration." [GOC:mah]
synonym: "positive regulation of immature T cell migration" RELATED [GOC:obol]
synonym: "positive regulation of immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of immature T-cell migration" RELATED [GOC:obol]
synonym: "positive regulation of immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000406 ! positive regulation of T cell migration
is_a: GO:2000410 ! regulation of thymocyte migration
relationship: positively_regulates GO:0072679 ! thymocyte migration

[Term]
id: GO:2000413
name: regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:mah]
synonym: "regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000410 ! regulation of thymocyte migration
relationship: regulates GO:0072681 ! fibronectin-dependent thymocyte migration

[Term]
id: GO:2000414
name: negative regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah]
synonym: "negative regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000411 ! negative regulation of thymocyte migration
is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration
relationship: negatively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration

[Term]
id: GO:2000415
name: positive regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah]
synonym: "positive regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000412 ! positive regulation of thymocyte migration
is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration
relationship: positively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration

[Term]
id: GO:2000416
name: regulation of eosinophil migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil migration." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
relationship: regulates GO:0072677 ! eosinophil migration

[Term]
id: GO:2000417
name: negative regulation of eosinophil migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration." [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:2000416 ! regulation of eosinophil migration
relationship: negatively_regulates GO:0072677 ! eosinophil migration

[Term]
id: GO:2000418
name: positive regulation of eosinophil migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil migration." [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:2000416 ! regulation of eosinophil migration
relationship: positively_regulates GO:0072677 ! eosinophil migration

[Term]
id: GO:2000419
name: regulation of eosinophil extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil extravasation." [GOC:mah]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:2000416 ! regulation of eosinophil migration
relationship: regulates GO:0072682 ! eosinophil extravasation

[Term]
id: GO:2000420
name: negative regulation of eosinophil extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:2000417 ! negative regulation of eosinophil migration
is_a: GO:2000419 ! regulation of eosinophil extravasation
relationship: negatively_regulates GO:0072682 ! eosinophil extravasation

[Term]
id: GO:2000421
name: positive regulation of eosinophil extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:2000418 ! positive regulation of eosinophil migration
is_a: GO:2000419 ! regulation of eosinophil extravasation
relationship: positively_regulates GO:0072682 ! eosinophil extravasation

[Term]
id: GO:2000422
name: regulation of eosinophil chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:2000416 ! regulation of eosinophil migration
relationship: regulates GO:0048245 ! eosinophil chemotaxis

[Term]
id: GO:2000423
name: negative regulation of eosinophil chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]
is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis
is_a: GO:2000417 ! negative regulation of eosinophil migration
is_a: GO:2000422 ! regulation of eosinophil chemotaxis
relationship: negatively_regulates GO:0048245 ! eosinophil chemotaxis

[Term]
id: GO:2000424
name: positive regulation of eosinophil chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]
is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis
is_a: GO:2000418 ! positive regulation of eosinophil migration
is_a: GO:2000422 ! regulation of eosinophil chemotaxis
relationship: positively_regulates GO:0048245 ! eosinophil chemotaxis

[Term]
id: GO:2000425
name: regulation of apoptotic cell clearance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]
synonym: "regulation of apoptotic cell removal" EXACT [GOC:obol]
synonym: "regulation of efferocytosis" EXACT [GOC:obol]
synonym: "regulation of programmed cell clearance" EXACT [GOC:obol]
is_a: GO:0050764 ! regulation of phagocytosis
relationship: regulates GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:2000426
name: negative regulation of apoptotic cell clearance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]
synonym: "negative regulation of apoptotic cell removal" EXACT [GOC:obol]
synonym: "negative regulation of efferocytosis" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell clearance" EXACT [GOC:obol]
is_a: GO:0050765 ! negative regulation of phagocytosis
is_a: GO:2000425 ! regulation of apoptotic cell clearance
relationship: negatively_regulates GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:2000427
name: positive regulation of apoptotic cell clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]
synonym: "positive regulation of apoptotic cell removal" EXACT [GOC:obol]
synonym: "positive regulation of efferocytosis" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell clearance" EXACT [GOC:obol]
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:2000425 ! regulation of apoptotic cell clearance
relationship: positively_regulates GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:2000428
name: regulation of neutrophil aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]
synonym: "regulation of neutrocyte aggregation" EXACT [GOC:obol]
synonym: "regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol]
synonym: "regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol]
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
relationship: regulates GO:0070488 ! neutrophil aggregation

[Term]
id: GO:2000429
name: negative regulation of neutrophil aggregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]
synonym: "negative regulation of neutrocyte aggregation" EXACT [GOC:obol]
synonym: "negative regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol]
synonym: "negative regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol]
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
is_a: GO:2000428 ! regulation of neutrophil aggregation
relationship: negatively_regulates GO:0070488 ! neutrophil aggregation

[Term]
id: GO:2000430
name: positive regulation of neutrophil aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]
synonym: "positive regulation of neutrocyte aggregation" EXACT [GOC:obol]
synonym: "positive regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol]
synonym: "positive regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol]
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
is_a: GO:2000428 ! regulation of neutrophil aggregation
relationship: positively_regulates GO:0070488 ! neutrophil aggregation

[Term]
id: GO:2000431
name: regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]
synonym: "regulation of contractile ring assembly" EXACT [GOC:obol]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0110020 ! regulation of actomyosin structure organization
relationship: regulates GO:0000915 ! actomyosin contractile ring assembly

[Term]
id: GO:2000432
name: negative regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]
synonym: "negative regulation of contractile ring assembly" EXACT [GOC:obol]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly
relationship: negatively_regulates GO:0000915 ! actomyosin contractile ring assembly

[Term]
id: GO:2000433
name: positive regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]
synonym: "positive regulation of contractile ring assembly" EXACT [GOC:obol]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly
relationship: positively_regulates GO:0000915 ! actomyosin contractile ring assembly

[Term]
id: GO:2000434
name: regulation of protein neddylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein neddylation." [GOC:obol]
synonym: "regulation of RUB1-protein conjugation" EXACT [GOC:obol]
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
relationship: regulates GO:0045116 ! protein neddylation

[Term]
id: GO:2000435
name: negative regulation of protein neddylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol]
synonym: "negative regulation of RUB1-protein conjugation" EXACT [GOC:obol]
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
is_a: GO:2000434 ! regulation of protein neddylation
relationship: negatively_regulates GO:0045116 ! protein neddylation

[Term]
id: GO:2000436
name: positive regulation of protein neddylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein neddylation." [GOC:obol]
synonym: "positive regulation of RUB1-protein conjugation" EXACT [GOC:obol]
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
is_a: GO:2000434 ! regulation of protein neddylation
relationship: positively_regulates GO:0045116 ! protein neddylation

[Term]
id: GO:2000437
name: regulation of monocyte extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte extravasation." [GOC:obol]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: regulates GO:0035696 ! monocyte extravasation

[Term]
id: GO:2000438
name: negative regulation of monocyte extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation." [GOC:obol]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:2000437 ! regulation of monocyte extravasation
relationship: negatively_regulates GO:0035696 ! monocyte extravasation

[Term]
id: GO:2000439
name: positive regulation of monocyte extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte extravasation." [GOC:obol]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:2000437 ! regulation of monocyte extravasation
relationship: positively_regulates GO:0035696 ! monocyte extravasation

[Term]
id: GO:2000440
name: regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]
synonym: "regulation of TLR15 signaling pathway" EXACT [GOC:obol]
synonym: "regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway
relationship: regulates GO:0035681 ! toll-like receptor 15 signaling pathway

[Term]
id: GO:2000441
name: negative regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]
synonym: "negative regulation of TLR15 signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway
relationship: negatively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway

[Term]
id: GO:2000442
name: positive regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]
synonym: "positive regulation of TLR15 signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway
is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway
relationship: positively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway

[Term]
id: GO:2000443
name: regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]
synonym: "regulation of TLR21 signaling pathway" EXACT [GOC:obol]
synonym: "regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0035682 ! toll-like receptor 21 signaling pathway

[Term]
id: GO:2000444
name: negative regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]
synonym: "negative regulation of TLR21 signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway
relationship: negatively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway

[Term]
id: GO:2000445
name: positive regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]
synonym: "positive regulation of TLR21 signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway
relationship: positively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway

[Term]
id: GO:2000446
name: regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]
synonym: "regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of MIF signaling pathway" EXACT [GOC:obol]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway

[Term]
id: GO:2000447
name: negative regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]
synonym: "negative regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of MIF signaling pathway" EXACT [GOC:obol]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway
relationship: negatively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway

[Term]
id: GO:2000448
name: positive regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]
synonym: "positive regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of MIF signaling pathway" EXACT [GOC:obol]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway
relationship: positively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway

[Term]
id: GO:2000449
name: regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]
is_a: GO:2000407 ! regulation of T cell extravasation
relationship: regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation

[Term]
id: GO:2000450
name: negative regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]
is_a: GO:2000408 ! negative regulation of T cell extravasation
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
relationship: negatively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation

[Term]
id: GO:2000451
name: positive regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]
is_a: GO:2000409 ! positive regulation of T cell extravasation
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
relationship: positively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation

[Term]
id: GO:2000452
name: regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
relationship: regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation

[Term]
id: GO:2000453
name: negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]
is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
relationship: negatively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation

[Term]
id: GO:2000454
name: positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]
is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
relationship: positively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation

[Term]
id: GO:2000455
name: regulation of T-helper 17 cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
relationship: regulates GO:0035699 ! T-helper 17 cell extravasation

[Term]
id: GO:2000456
name: negative regulation of T-helper 17 cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]
is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation
relationship: negatively_regulates GO:0035699 ! T-helper 17 cell extravasation

[Term]
id: GO:2000457
name: positive regulation of T-helper 17 cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]
is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation
relationship: positively_regulates GO:0035699 ! T-helper 17 cell extravasation

[Term]
id: GO:2000458
name: regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1903975 ! regulation of glial cell migration
relationship: regulates GO:0035700 ! astrocyte chemotaxis

[Term]
id: GO:2000459
name: negative regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1903976 ! negative regulation of glial cell migration
is_a: GO:2000458 ! regulation of astrocyte chemotaxis
relationship: negatively_regulates GO:0035700 ! astrocyte chemotaxis

[Term]
id: GO:2000460
name: obsolete regulation of eukaryotic cell surface binding
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]
comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion.
synonym: "regulation of eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0031347
consider: GO:1900120

[Term]
id: GO:2000461
name: obsolete negative regulation of eukaryotic cell surface binding
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]
comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion.
synonym: "negative regulation of eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0031347
consider: GO:1900121

[Term]
id: GO:2000462
name: obsolete positive regulation of eukaryotic cell surface binding
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]
comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion.
synonym: "positive regulation of eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0031347
consider: GO:1900122

[Term]
id: GO:2000463
name: positive regulation of excitatory postsynaptic potential
namespace: biological_process
def: "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:bf, GOC:BHF]
synonym: "positive regulation of EPSP" RELATED [GOC:bf, GOC:obol]
synonym: "positive regulation of excitatory post-synaptic membrane potential" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
relationship: positively_regulates GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:2000464
name: positive regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1903977 ! positive regulation of glial cell migration
is_a: GO:2000458 ! regulation of astrocyte chemotaxis
relationship: positively_regulates GO:0035700 ! astrocyte chemotaxis

[Term]
id: GO:2000465
name: regulation of glycogen (starch) synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol]
synonym: "regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
synonym: "regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "regulation of UDP-glycogen synthase activity" EXACT [GOC:obol]
synonym: "regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol]
synonym: "regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol]
synonym: "regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:2000466
name: negative regulation of glycogen (starch) synthase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDP-glycogen synthase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "negative regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity

[Term]
id: GO:2000467
name: positive regulation of glycogen (starch) synthase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDP-glycogen synthase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "positive regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity

[Term]
id: GO:2000468
name: regulation of peroxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peroxidase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol]
synonym: "regulation of oxyperoxidase activity" EXACT [GOC:obol]
synonym: "regulation of peroxidase reaction" EXACT [GOC:obol]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:2000469
name: negative regulation of peroxidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol]
synonym: "negative regulation of oxyperoxidase activity" EXACT [GOC:obol]
synonym: "negative regulation of peroxidase reaction" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:2000468 ! regulation of peroxidase activity

[Term]
id: GO:2000470
name: positive regulation of peroxidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peroxidase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol]
synonym: "positive regulation of oxyperoxidase activity" EXACT [GOC:obol]
synonym: "positive regulation of peroxidase reaction" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:2000468 ! regulation of peroxidase activity

[Term]
id: GO:2000471
name: regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0035701 ! hematopoietic stem cell migration

[Term]
id: GO:2000472
name: negative regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
relationship: negatively_regulates GO:0035701 ! hematopoietic stem cell migration

[Term]
id: GO:2000473
name: positive regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
relationship: positively_regulates GO:0035701 ! hematopoietic stem cell migration

[Term]
id: GO:2000474
name: regulation of opioid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]
synonym: "regulation of opioid receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
relationship: regulates GO:0038003 ! G protein-coupled opioid receptor signaling pathway

[Term]
id: GO:2000475
name: negative regulation of opioid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]
synonym: "negative regulation of opioid receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
is_a: GO:2000474 ! regulation of opioid receptor signaling pathway
relationship: negatively_regulates GO:0038003 ! G protein-coupled opioid receptor signaling pathway

[Term]
id: GO:2000476
name: positive regulation of opioid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]
synonym: "positive regulation of opioid receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway
is_a: GO:2000474 ! regulation of opioid receptor signaling pathway
relationship: positively_regulates GO:0038003 ! G protein-coupled opioid receptor signaling pathway

[Term]
id: GO:2000477
name: regulation of metanephric podocyte development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol]
synonym: "regulation of metanephric glomerular visceral epithelial cell development" EXACT []
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0072249 ! metanephric podocyte development

[Term]
id: GO:2000478
name: positive regulation of metanephric podocyte development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol]
synonym: "positive regulation of metanephric glomerular visceral epithelial cell development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:2000477 ! regulation of metanephric podocyte development
relationship: positively_regulates GO:0072249 ! metanephric podocyte development

[Term]
id: GO:2000479
name: regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of AMPK" RELATED [GOC:obol]
synonym: "regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol]
synonym: "regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol]
synonym: "regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of PKA" RELATED [GOC:obol]
synonym: "regulation of PKA C" RELATED [GOC:obol]
synonym: "regulation of protein kinase A activity" RELATED [GOC:obol]
synonym: "regulation of STK22" RELATED [GOC:obol]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity

[Term]
id: GO:2000480
name: negative regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of AMPK" RELATED [GOC:obol]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of PKA" RELATED [GOC:obol]
synonym: "negative regulation of PKA C" RELATED [GOC:obol]
synonym: "negative regulation of protein kinase A activity" RELATED [GOC:obol]
synonym: "negative regulation of STK22" RELATED [GOC:obol]
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity

[Term]
id: GO:2000481
name: positive regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of AMPK" RELATED [GOC:obol]
synonym: "positive regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol]
synonym: "positive regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol]
synonym: "positive regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of PKA" RELATED [GOC:obol]
synonym: "positive regulation of PKA C" RELATED [GOC:obol]
synonym: "positive regulation of protein kinase A activity" RELATED [GOC:obol]
synonym: "positive regulation of STK22" RELATED [GOC:obol]
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity

[Term]
id: GO:2000485
name: regulation of glutamine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamine transport." [GOC:obol]
synonym: "regulation of L-glutamine transport" RELATED [GOC:obol]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0006868 ! glutamine transport

[Term]
id: GO:2000486
name: negative regulation of glutamine transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport." [GOC:obol]
synonym: "negative regulation of L-glutamine transport" RELATED [GOC:obol]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:2000485 ! regulation of glutamine transport
relationship: negatively_regulates GO:0006868 ! glutamine transport

[Term]
id: GO:2000487
name: positive regulation of glutamine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamine transport." [GOC:obol]
synonym: "positive regulation of L-glutamine transport" RELATED [GOC:obol]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:2000485 ! regulation of glutamine transport
relationship: positively_regulates GO:0006868 ! glutamine transport

[Term]
id: GO:2000488
name: positive regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process." [GOC:obol]
synonym: "positive regulation of brassinosteroid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of brassinosteroid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of brassinosteroid formation" EXACT [GOC:obol]
synonym: "positive regulation of brassinosteroid synthesis" EXACT [GOC:obol]
is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
relationship: positively_regulates GO:0016132 ! brassinosteroid biosynthetic process

[Term]
id: GO:2000489
name: regulation of hepatic stellate cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0035733 ! hepatic stellate cell activation

[Term]
id: GO:2000490
name: negative regulation of hepatic stellate cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:2000489 ! regulation of hepatic stellate cell activation
relationship: negatively_regulates GO:0035733 ! hepatic stellate cell activation

[Term]
id: GO:2000491
name: positive regulation of hepatic stellate cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:2000489 ! regulation of hepatic stellate cell activation
relationship: positively_regulates GO:0035733 ! hepatic stellate cell activation

[Term]
id: GO:2000492
name: regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]
synonym: "regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0035655 ! interleukin-18-mediated signaling pathway

[Term]
id: GO:2000493
name: negative regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]
synonym: "negative regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway
relationship: negatively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway

[Term]
id: GO:2000494
name: positive regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]
synonym: "positive regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway
relationship: positively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway

[Term]
id: GO:2000495
name: regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0042127 ! regulation of cell population proliferation
relationship: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis

[Term]
id: GO:2000496
name: negative regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
relationship: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis

[Term]
id: GO:2000497
name: positive regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
relationship: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis

[Term]
id: GO:2000498
name: obsolete regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]
comment: This term was made obsolete because it is ill-defined.
synonym: "regulation of induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000499
name: obsolete negative regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]
comment: This term was made obsolete because it is ill-defined.
synonym: "negative regulation of induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "negative regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000500
name: obsolete positive regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]
comment: This term was made obsolete because it is ill-defined.
synonym: "positive regulation of induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "positive regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000501
name: regulation of natural killer cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
relationship: regulates GO:0035747 ! natural killer cell chemotaxis

[Term]
id: GO:2000502
name: negative regulation of natural killer cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]
is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis
is_a: GO:2000501 ! regulation of natural killer cell chemotaxis
relationship: negatively_regulates GO:0035747 ! natural killer cell chemotaxis

[Term]
id: GO:2000503
name: positive regulation of natural killer cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]
is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis
is_a: GO:2000501 ! regulation of natural killer cell chemotaxis
relationship: positively_regulates GO:0035747 ! natural killer cell chemotaxis

[Term]
id: GO:2000504
name: positive regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol]
synonym: "positive regulation of blood vessel remodelling" EXACT []
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0060312 ! regulation of blood vessel remodeling
relationship: positively_regulates GO:0001974 ! blood vessel remodeling

[Term]
id: GO:2000508
name: regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: regulates GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:2000509
name: negative regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
relationship: negatively_regulates GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:2000510
name: positive regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
relationship: positively_regulates GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:2000511
name: regulation of granzyme A production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granzyme A production." [GOC:obol]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: regulates GO:0035746 ! granzyme A production

[Term]
id: GO:2000512
name: negative regulation of granzyme A production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production." [GOC:obol]
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:2000511 ! regulation of granzyme A production
relationship: negatively_regulates GO:0035746 ! granzyme A production

[Term]
id: GO:2000513
name: positive regulation of granzyme A production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granzyme A production." [GOC:obol]
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:2000511 ! regulation of granzyme A production
relationship: positively_regulates GO:0035746 ! granzyme A production

[Term]
id: GO:2000514
name: regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation

[Term]
id: GO:2000515
name: negative regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
relationship: negatively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation

[Term]
id: GO:2000516
name: positive regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
relationship: positively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation

[Term]
id: GO:2000517
name: regulation of T-helper 1 cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]
synonym: "regulation of Th1 cell activation" EXACT [GOC:obol]
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
relationship: regulates GO:0035711 ! T-helper 1 cell activation

[Term]
id: GO:2000518
name: negative regulation of T-helper 1 cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]
synonym: "negative regulation of Th1 cell activation" EXACT [GOC:obol]
is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000517 ! regulation of T-helper 1 cell activation
relationship: negatively_regulates GO:0035711 ! T-helper 1 cell activation

[Term]
id: GO:2000519
name: positive regulation of T-helper 1 cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]
synonym: "positive regulation of Th1 cell activation" EXACT [GOC:obol]
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000517 ! regulation of T-helper 1 cell activation
relationship: positively_regulates GO:0035711 ! T-helper 1 cell activation

[Term]
id: GO:2000520
name: regulation of immunological synapse formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immunological synapse formation." [GOC:obol]
synonym: "regulation of formation of immunological synapse" EXACT [GOC:obol]
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0001771 ! immunological synapse formation

[Term]
id: GO:2000521
name: negative regulation of immunological synapse formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation." [GOC:obol]
synonym: "negative regulation of formation of immunological synapse" EXACT [GOC:obol]
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:2000520 ! regulation of immunological synapse formation
relationship: negatively_regulates GO:0001771 ! immunological synapse formation

[Term]
id: GO:2000522
name: positive regulation of immunological synapse formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immunological synapse formation." [GOC:obol]
synonym: "positive regulation of formation of immunological synapse" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000520 ! regulation of immunological synapse formation
relationship: positively_regulates GO:0001771 ! immunological synapse formation

[Term]
id: GO:2000523
name: regulation of T cell costimulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell costimulation." [GOC:obol]
synonym: "regulation of T cell co-stimulation" EXACT [GOC:obol]
synonym: "regulation of T lymphocyte costimulation" EXACT [GOC:obol]
synonym: "regulation of T-cell co-stimulation" EXACT [GOC:obol]
synonym: "regulation of T-cell costimulation" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte costimulation" EXACT [GOC:obol]
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
relationship: regulates GO:0031295 ! T cell costimulation

[Term]
id: GO:2000524
name: negative regulation of T cell costimulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation." [GOC:obol]
synonym: "negative regulation of T cell co-stimulation" EXACT [GOC:obol]
synonym: "negative regulation of T lymphocyte costimulation" EXACT [GOC:obol]
synonym: "negative regulation of T-cell co-stimulation" EXACT [GOC:obol]
synonym: "negative regulation of T-cell costimulation" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte costimulation" EXACT [GOC:obol]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:2000523 ! regulation of T cell costimulation
relationship: negatively_regulates GO:0031295 ! T cell costimulation

[Term]
id: GO:2000525
name: positive regulation of T cell costimulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell costimulation." [GOC:obol]
synonym: "positive regulation of T cell co-stimulation" EXACT [GOC:obol]
synonym: "positive regulation of T lymphocyte costimulation" EXACT [GOC:obol]
synonym: "positive regulation of T-cell co-stimulation" EXACT [GOC:obol]
synonym: "positive regulation of T-cell costimulation" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte costimulation" EXACT [GOC:obol]
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:2000523 ! regulation of T cell costimulation
relationship: positively_regulates GO:0031295 ! T cell costimulation

[Term]
id: GO:2000526
name: positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
namespace: biological_process
def: "Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation." [GOC:obol]
synonym: "positive regulation of glycoprotein biosynthetic process of formation of immunological synapse" EXACT [GOC:obol]
synonym: "positive regulation of glycoprotein biosynthetic process of immunological synapse formation" EXACT [GOC:obol]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
relationship: part_of GO:0001771 ! immunological synapse formation

[Term]
id: GO:2000527
name: regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
relationship: regulates GO:0002408 ! myeloid dendritic cell chemotaxis

[Term]
id: GO:2000528
name: negative regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis
is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis
relationship: negatively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis

[Term]
id: GO:2000529
name: positive regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis
is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis
relationship: positively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis

[Term]
id: GO:2000530
name: obsolete positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of insulin secretion involved in cellular response to glucose stimulus." [GOC:obol]
synonym: "positive regulation of regulation of insulin secretion in response to glucose" EXACT [GOC:obol]
synonym: "positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus" EXACT []
is_obsolete: true

[Term]
id: GO:2000531
name: obsolete regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the biosynthesis of fatty acids, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:vw]
comment: This term was obsoleted because it represents a GO-CAM model.
is_obsolete: true

[Term]
id: GO:2000532
name: regulation of renal albumin absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:0097018 ! renal albumin absorption

[Term]
id: GO:2000533
name: negative regulation of renal albumin absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000532 ! regulation of renal albumin absorption
relationship: negatively_regulates GO:0097018 ! renal albumin absorption

[Term]
id: GO:2000534
name: positive regulation of renal albumin absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000532 ! regulation of renal albumin absorption
relationship: positively_regulates GO:0097018 ! renal albumin absorption

[Term]
id: GO:2000535
name: regulation of entry of bacterium into host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol]
synonym: "regulation of bacterial entry into host cell" EXACT [GOC:obol]
synonym: "regulation of invasion of bacteria into host cell" EXACT [GOC:obol]
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0035635 ! entry of bacterium into host cell

[Term]
id: GO:2000536
name: negative regulation of entry of bacterium into host cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol]
synonym: "negative regulation of bacterial entry into host cell" EXACT [GOC:obol]
synonym: "negative regulation of invasion of bacteria into host cell" EXACT [GOC:obol]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:2000535 ! regulation of entry of bacterium into host cell
relationship: negatively_regulates GO:0035635 ! entry of bacterium into host cell

[Term]
id: GO:2000537
name: regulation of B cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell chemotaxis." [GOC:obol]
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
relationship: regulates GO:0035754 ! B cell chemotaxis

[Term]
id: GO:2000538
name: positive regulation of B cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis." [GOC:obol]
is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis
is_a: GO:2000537 ! regulation of B cell chemotaxis
relationship: positively_regulates GO:0035754 ! B cell chemotaxis

[Term]
id: GO:2000539
name: regulation of protein geranylgeranylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol]
synonym: "regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0018344 ! protein geranylgeranylation

[Term]
id: GO:2000540
name: negative regulation of protein geranylgeranylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol]
synonym: "negative regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:2000539 ! regulation of protein geranylgeranylation
relationship: negatively_regulates GO:0018344 ! protein geranylgeranylation

[Term]
id: GO:2000541
name: positive regulation of protein geranylgeranylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol]
synonym: "positive regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:2000539 ! regulation of protein geranylgeranylation
relationship: positively_regulates GO:0018344 ! protein geranylgeranylation

[Term]
id: GO:2000542
name: negative regulation of gastrulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0045992 ! negative regulation of embryonic development
relationship: negatively_regulates GO:0007369 ! gastrulation

[Term]
id: GO:2000543
name: positive regulation of gastrulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0040019 ! positive regulation of embryonic development
relationship: positively_regulates GO:0007369 ! gastrulation

[Term]
id: GO:2000544
name: regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]
is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
relationship: regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor

[Term]
id: GO:2000545
name: negative regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]
is_a: GO:1904848 ! negative regulation of cell chemotaxis to fibroblast growth factor
is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor
is_a: GO:2001027 ! negative regulation of endothelial cell chemotaxis
relationship: negatively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor

[Term]
id: GO:2000546
name: positive regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]
is_a: GO:1904849 ! positive regulation of cell chemotaxis to fibroblast growth factor
is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor
is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis
relationship: positively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor

[Term]
id: GO:2000547
name: regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
relationship: regulates GO:0097026 ! dendritic cell dendrite assembly

[Term]
id: GO:2000548
name: negative regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "negative regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
relationship: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly

[Term]
id: GO:2000549
name: positive regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "positive regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
relationship: positively_regulates GO:0097026 ! dendritic cell dendrite assembly

[Term]
id: GO:2000550
name: negative regulation of B cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis." [GOC:obol]
is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis
is_a: GO:2000537 ! regulation of B cell chemotaxis
relationship: negatively_regulates GO:0035754 ! B cell chemotaxis

[Term]
id: GO:2000551
name: regulation of T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]
synonym: "regulation of Th2 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002724 ! regulation of T cell cytokine production
is_a: GO:0002828 ! regulation of type 2 immune response
relationship: regulates GO:0035745 ! T-helper 2 cell cytokine production

[Term]
id: GO:2000552
name: negative regulation of T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]
synonym: "negative regulation of Th2 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002725 ! negative regulation of T cell cytokine production
is_a: GO:0002829 ! negative regulation of type 2 immune response
is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production
relationship: negatively_regulates GO:0035745 ! T-helper 2 cell cytokine production

[Term]
id: GO:2000553
name: positive regulation of T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]
synonym: "positive regulation of Th2 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002726 ! positive regulation of T cell cytokine production
is_a: GO:0002830 ! positive regulation of type 2 immune response
is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production
relationship: positively_regulates GO:0035745 ! T-helper 2 cell cytokine production

[Term]
id: GO:2000554
name: regulation of T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]
synonym: "regulation of Th1 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002724 ! regulation of T cell cytokine production
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
relationship: regulates GO:0035744 ! T-helper 1 cell cytokine production

[Term]
id: GO:2000555
name: negative regulation of T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]
synonym: "negative regulation of Th1 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002725 ! negative regulation of T cell cytokine production
is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response
is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production
relationship: negatively_regulates GO:0035744 ! T-helper 1 cell cytokine production

[Term]
id: GO:2000556
name: positive regulation of T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]
synonym: "positive regulation of Th1 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002726 ! positive regulation of T cell cytokine production
is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response
is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production
relationship: positively_regulates GO:0035744 ! T-helper 1 cell cytokine production

[Term]
id: GO:2000557
name: regulation of immunoglobulin production in mucosal tissue
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol]
synonym: "regulation of antibody production in mucosal tissue" EXACT [GOC:obol]
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: regulates GO:0002426 ! immunoglobulin production in mucosal tissue

[Term]
id: GO:2000558
name: positive regulation of immunoglobulin production in mucosal tissue
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol]
synonym: "positive regulation of antibody production in mucosal tissue" EXACT [GOC:obol]
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:2000557 ! regulation of immunoglobulin production in mucosal tissue
relationship: positively_regulates GO:0002426 ! immunoglobulin production in mucosal tissue

[Term]
id: GO:2000559
name: regulation of CD24 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol]
synonym: "regulation of CD24 anabolism" EXACT [GOC:obol]
synonym: "regulation of CD24 biosynthesis" EXACT [GOC:obol]
synonym: "regulation of CD24 biosynthetic process" EXACT []
synonym: "regulation of CD24 formation" EXACT [GOC:obol]
synonym: "regulation of CD24 synthesis" EXACT [GOC:obol]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0035724 ! CD24 biosynthetic process

[Term]
id: GO:2000560
name: positive regulation of CD24 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol]
synonym: "positive regulation of CD24 anabolism" EXACT [GOC:obol]
synonym: "positive regulation of CD24 biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of CD24 biosynthetic process" EXACT []
synonym: "positive regulation of CD24 formation" EXACT [GOC:obol]
synonym: "positive regulation of CD24 synthesis" EXACT [GOC:obol]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:2000559 ! regulation of CD24 production
relationship: positively_regulates GO:0035724 ! CD24 biosynthetic process

[Term]
id: GO:2000561
name: regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
relationship: regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation

[Term]
id: GO:2000562
name: negative regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation
is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation
relationship: negatively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation

[Term]
id: GO:2000563
name: positive regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation
relationship: positively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation

[Term]
id: GO:2000564
name: regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
relationship: regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation

[Term]
id: GO:2000565
name: negative regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation
is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation
is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation
relationship: negatively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation

[Term]
id: GO:2000566
name: positive regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation
is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation
is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation
relationship: positively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation

[Term]
id: GO:2000567
name: regulation of memory T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of memory T cell activation." [GOC:obol]
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0035709 ! memory T cell activation

[Term]
id: GO:2000568
name: positive regulation of memory T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of memory T cell activation." [GOC:obol]
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:2000567 ! regulation of memory T cell activation
relationship: positively_regulates GO:0035709 ! memory T cell activation

[Term]
id: GO:2000569
name: regulation of T-helper 2 cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol]
synonym: "regulation of Th2 cell activation" EXACT [GOC:obol]
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
relationship: regulates GO:0035712 ! T-helper 2 cell activation

[Term]
id: GO:2000570
name: positive regulation of T-helper 2 cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol]
synonym: "positive regulation of Th2 cell activation" EXACT [GOC:obol]
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000569 ! regulation of T-helper 2 cell activation
relationship: positively_regulates GO:0035712 ! T-helper 2 cell activation

[Term]
id: GO:2000571
name: regulation of interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol]
synonym: "regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol]
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
relationship: regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes

[Term]
id: GO:2000572
name: positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol]
synonym: "positive regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol]
is_a: GO:0048295 ! positive regulation of isotype switching to IgE isotypes
is_a: GO:2000571 ! regulation of interleukin-4-dependent isotype switching to IgE isotypes
relationship: positively_regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes

[Term]
id: GO:2000573
name: positive regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of DNA formation" EXACT [GOC:obol]
synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
relationship: positively_regulates GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:2000574
name: obsolete regulation of microtubule motor activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of microtubule motor activity." [GOC:kmv]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of axonemal motor activity" RELATED [GOC:obol]
synonym: "regulation of dynein" RELATED [GOC:obol]
synonym: "regulation of dynein ATPase activity" RELATED [GOC:obol]
synonym: "regulation of kinesin" RELATED [GOC:obol]
synonym: "regulation of kinesin motor activity" RELATED [GOC:obol]
synonym: "regulation of kinetochore motor activity" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0140659

[Term]
id: GO:2000575
name: obsolete negative regulation of microtubule motor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of microtubule motor activity." [GOC:kmv]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of axonemal motor activity" RELATED [GOC:obol]
synonym: "negative regulation of dynein" RELATED [GOC:obol]
synonym: "negative regulation of dynein ATPase activity" RELATED [GOC:obol]
synonym: "negative regulation of kinesin" RELATED [GOC:obol]
synonym: "negative regulation of kinesin motor activity" RELATED [GOC:obol]
synonym: "negative regulation of kinetochore motor activity" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0140661

[Term]
id: GO:2000576
name: obsolete positive regulation of microtubule motor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of microtubule motor activity." [GOC:kmv]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of axonemal motor activity" RELATED [GOC:obol]
synonym: "positive regulation of dynein" RELATED [GOC:obol]
synonym: "positive regulation of dynein ATPase activity" RELATED [GOC:obol]
synonym: "positive regulation of kinesin" RELATED [GOC:obol]
synonym: "positive regulation of kinesin motor activity" RELATED [GOC:obol]
synonym: "positive regulation of kinetochore motor activity" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0140660

[Term]
id: GO:2000577
name: obsolete regulation of microtubule motor activity, minus-end-directed
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of ATP-dependent microtubule motor activity, minus-end-directed" EXACT []
synonym: "regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol]
synonym: "regulation of minus-end-directed kinesin ATPase activity" RELATED [GOC:obol]
synonym: "regulation of minus-end-directed microtubule motor activity" BROAD []
is_obsolete: true
consider: GO:0140659

[Term]
id: GO:2000578
name: obsolete negative regulation of microtubule motor activity, minus-end-directed
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of ATP-dependent microtubule motor activity, minus-end-directed" EXACT []
synonym: "negative regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol]
synonym: "negative regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "negative regulation of minus-end-directed microtubule motor activity" BROAD []
is_obsolete: true
consider: GO:0140661

[Term]
id: GO:2000579
name: obsolete positive regulation of microtubule motor activity, minus-end-directed
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of ATP-dependent microtubule motor activity, minus-end-directed" EXACT []
synonym: "positive regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol]
synonym: "positive regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "positive regulation of minus-end-directed microtubule motor activity" BROAD []
is_obsolete: true
consider: GO:0140660

[Term]
id: GO:2000580
name: obsolete regulation of microtubule motor activity, plus-end-directed
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of ATP-dependent microtubule motor activity, plus-end-directed" EXACT []
synonym: "regulation of kinesin activity" RELATED [GOC:obol]
synonym: "regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol]
synonym: "regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "regulation of plus-end-directed microtubule motor activity" BROAD []
is_obsolete: true
consider: GO:0140659

[Term]
id: GO:2000581
name: obsolete negative regulation of microtubule motor activity, plus-end-directed
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of ATP-dependent microtubule motor activity, plus-end-directed" EXACT []
synonym: "negative regulation of kinesin activity" RELATED [GOC:obol]
synonym: "negative regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol]
synonym: "negative regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "negative regulation of plus-end-directed microtubule motor activity" BROAD []
is_obsolete: true
consider: GO:0140661

[Term]
id: GO:2000582
name: obsolete positive regulation of microtubule motor activity, plus-end-directed
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" EXACT []
synonym: "positive regulation of kinesin activity" RELATED [GOC:obol]
synonym: "positive regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol]
synonym: "positive regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "positive regulation of plus-end-directed microtubule motor activity" BROAD []
is_obsolete: true
consider: GO:0140660

[Term]
id: GO:2000583
name: regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol]
synonym: "regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol]
synonym: "regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
relationship: regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway

[Term]
id: GO:2000584
name: negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol, GOC:yaf]
synonym: "negative regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway
relationship: negatively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway

[Term]
id: GO:2000585
name: positive regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol]
synonym: "positive regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway
relationship: positively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway

[Term]
id: GO:2000586
name: regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]
synonym: "regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol]
synonym: "regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
relationship: regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway

[Term]
id: GO:2000587
name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]
synonym: "negative regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway
relationship: negatively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway

[Term]
id: GO:2000588
name: positive regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]
synonym: "positive regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway
relationship: positively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway

[Term]
id: GO:2000589
name: regulation of metanephric mesenchymal cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol]
synonym: "regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0035789 ! metanephric mesenchymal cell migration

[Term]
id: GO:2000590
name: negative regulation of metanephric mesenchymal cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol]
synonym: "negative regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration
relationship: negatively_regulates GO:0035789 ! metanephric mesenchymal cell migration

[Term]
id: GO:2000591
name: positive regulation of metanephric mesenchymal cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "positive regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration
relationship: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration

[Term]
id: GO:2000592
name: regulation of metanephric DCT cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]
synonym: "regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0072240 ! metanephric DCT cell differentiation

[Term]
id: GO:2000593
name: negative regulation of metanephric DCT cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]
synonym: "negative regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation
relationship: negatively_regulates GO:0072240 ! metanephric DCT cell differentiation

[Term]
id: GO:2000594
name: positive regulation of metanephric DCT cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]
synonym: "positive regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation
relationship: positively_regulates GO:0072240 ! metanephric DCT cell differentiation

[Term]
id: GO:2000595
name: regulation of optic nerve formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of optic nerve formation." [GOC:obol]
synonym: "regulation of CN II biosynthesis" RELATED [GOC:obol]
synonym: "regulation of CN II formation" RELATED [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0021634 ! optic nerve formation

[Term]
id: GO:2000596
name: negative regulation of optic nerve formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation." [GOC:obol]
synonym: "negative regulation of CN II biosynthesis" RELATED [GOC:obol]
synonym: "negative regulation of CN II formation" RELATED [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000595 ! regulation of optic nerve formation
relationship: negatively_regulates GO:0021634 ! optic nerve formation

[Term]
id: GO:2000597
name: positive regulation of optic nerve formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of optic nerve formation." [GOC:obol]
synonym: "positive regulation of CN II biosynthesis" RELATED [GOC:obol]
synonym: "positive regulation of CN II formation" RELATED [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000595 ! regulation of optic nerve formation
relationship: positively_regulates GO:0021634 ! optic nerve formation

[Term]
id: GO:2000601
name: positive regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]
synonym: "positive regulation of actin filament branch nucleation" EXACT [GOC:obol]
synonym: "positive regulation of branched actin filament nucleation" EXACT [GOC:obol]
is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation
is_a: GO:0051127 ! positive regulation of actin nucleation
relationship: positively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation

[Term]
id: GO:2000602
name: obsolete regulation of interphase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of interphase of mitotic cell cycle." [GOC:obol]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of interphase of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:2000603
name: regulation of secondary growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary growth." [GOC:obol]
is_a: GO:0040008 ! regulation of growth
relationship: regulates GO:0080117 ! secondary growth

[Term]
id: GO:2000604
name: negative regulation of secondary growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth." [GOC:obol]
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:2000603 ! regulation of secondary growth
relationship: negatively_regulates GO:0080117 ! secondary growth

[Term]
id: GO:2000605
name: positive regulation of secondary growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary growth." [GOC:obol]
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:2000603 ! regulation of secondary growth
relationship: positively_regulates GO:0080117 ! secondary growth

[Term]
id: GO:2000606
name: regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
relationship: regulates GO:0061209 ! cell proliferation involved in mesonephros development

[Term]
id: GO:2000607
name: negative regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
relationship: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development

[Term]
id: GO:2000608
name: positive regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
relationship: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development

[Term]
id: GO:2000609
name: regulation of thyroid hormone generation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [GOC:obol]
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0006590 ! thyroid hormone generation

[Term]
id: GO:2000610
name: negative regulation of thyroid hormone generation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [GOC:obol]
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:2000609 ! regulation of thyroid hormone generation
relationship: negatively_regulates GO:0006590 ! thyroid hormone generation

[Term]
id: GO:2000611
name: positive regulation of thyroid hormone generation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [GOC:obol]
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:2000609 ! regulation of thyroid hormone generation
relationship: positively_regulates GO:0006590 ! thyroid hormone generation

[Term]
id: GO:2000612
name: regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]
synonym: "regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol]
synonym: "regulation of TSH secretion" EXACT [GOC:obol]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0070460 ! thyroid-stimulating hormone secretion

[Term]
id: GO:2000613
name: negative regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]
synonym: "negative regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol]
synonym: "negative regulation of TSH secretion" EXACT [GOC:obol]
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion
relationship: negatively_regulates GO:0070460 ! thyroid-stimulating hormone secretion

[Term]
id: GO:2000614
name: positive regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]
synonym: "positive regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol]
synonym: "positive regulation of TSH secretion" EXACT [GOC:obol]
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion
relationship: positively_regulates GO:0070460 ! thyroid-stimulating hormone secretion

[Term]
id: GO:2000615
name: obsolete regulation of histone H3-K9 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone H3 acetylation at K9" EXACT [GOC:obol]
synonym: "regulation of histone H3K9 acetylation" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000616
name: obsolete negative regulation of histone H3-K9 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of histone H3 acetylation at K9" EXACT [GOC:obol]
synonym: "negative regulation of histone H3K9 acetylation" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000617
name: obsolete positive regulation of histone H3-K9 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of histone H3 acetylation at K9" EXACT [GOC:obol]
synonym: "positive regulation of histone H3K9 acetylation" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000618
name: obsolete regulation of histone H4-K16 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone H4 acetylation at K16" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0031452

[Term]
id: GO:2000619
name: obsolete negative regulation of histone H4-K16 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of histone H4 acetylation at K16" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000620
name: obsolete positive regulation of histone H4-K16 acetylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of histone H4 acetylation at K16" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000621
name: regulation of DNA replication termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication termination." [GOC:obol]
is_a: GO:0090329 ! regulation of DNA-templated DNA replication
relationship: regulates GO:0006274 ! DNA replication termination

[Term]
id: GO:2000622
name: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]
synonym: "regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol]
synonym: "regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol]
synonym: "regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol]
synonym: "regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol]
is_a: GO:0061013 ! regulation of mRNA catabolic process
relationship: regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

[Term]
id: GO:2000623
name: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]
synonym: "negative regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "negative regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol]
synonym: "negative regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol]
synonym: "negative regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "negative regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol]
synonym: "negative regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol]
is_a: GO:1902373 ! negative regulation of mRNA catabolic process
is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
relationship: negatively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

[Term]
id: GO:2000624
name: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]
synonym: "positive regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "positive regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol]
synonym: "positive regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol]
synonym: "positive regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "positive regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol]
synonym: "positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol]
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
relationship: positively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

[Term]
id: GO:2000625
name: regulation of miRNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of miRNA catabolic process." [GOC:dph]
synonym: "regulation of microRNA catabolic process" EXACT [GOC:obol]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:2000628 ! regulation of miRNA metabolic process
relationship: regulates GO:0010587 ! miRNA catabolic process

[Term]
id: GO:2000626
name: negative regulation of miRNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process." [GOC:dph]
synonym: "negative regulation of microRNA catabolic process" EXACT [GOC:obol]
is_a: GO:1902369 ! negative regulation of RNA catabolic process
is_a: GO:2000625 ! regulation of miRNA catabolic process
is_a: GO:2000629 ! negative regulation of miRNA metabolic process
relationship: negatively_regulates GO:0010587 ! miRNA catabolic process

[Term]
id: GO:2000627
name: positive regulation of miRNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of miRNA catabolic process." [GOC:dph]
synonym: "positive regulation of microRNA catabolic process" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000625 ! regulation of miRNA catabolic process
is_a: GO:2000630 ! positive regulation of miRNA metabolic process
relationship: positively_regulates GO:0010587 ! miRNA catabolic process

[Term]
id: GO:2000628
name: regulation of miRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph]
synonym: "regulation of microRNA metabolic process" EXACT [GOC:obol]
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0010586 ! miRNA metabolic process

[Term]
id: GO:2000629
name: negative regulation of miRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process." [GOC:dph]
synonym: "negative regulation of microRNA metabolic process" EXACT [GOC:obol]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:2000628 ! regulation of miRNA metabolic process
relationship: negatively_regulates GO:0010586 ! miRNA metabolic process

[Term]
id: GO:2000630
name: positive regulation of miRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph]
synonym: "positive regulation of microRNA metabolic process" EXACT [GOC:obol]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:2000628 ! regulation of miRNA metabolic process
relationship: positively_regulates GO:0010586 ! miRNA metabolic process

[Term]
id: GO:2000631
name: regulation of pre-miRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]
synonym: "regulation of miRNA maturation" EXACT []
synonym: "regulation of pre-microRNA processing" EXACT []
is_a: GO:1903798 ! regulation of miRNA processing
relationship: regulates GO:0031054 ! pre-miRNA processing

[Term]
id: GO:2000632
name: negative regulation of pre-miRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]
synonym: "negative regulation of miRNA maturation" EXACT []
synonym: "negative regulation of pre-microRNA processing" EXACT [GOC:obol]
is_a: GO:1903799 ! negative regulation of miRNA processing
is_a: GO:2000631 ! regulation of pre-miRNA processing
relationship: negatively_regulates GO:0031054 ! pre-miRNA processing

[Term]
id: GO:2000633
name: positive regulation of pre-miRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]
synonym: "positive regulation of miRNA maturation" EXACT []
synonym: "positive regulation of pre-microRNA processing" EXACT [GOC:obol]
is_a: GO:1903800 ! positive regulation of miRNA processing
is_a: GO:2000631 ! regulation of pre-miRNA processing
relationship: positively_regulates GO:0031054 ! pre-miRNA processing

[Term]
id: GO:2000634
name: regulation of primary miRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]
synonym: "regulation of pri-miRNA processing" EXACT [GOC:obol]
synonym: "regulation of primary microRNA processing" EXACT [GOC:obol]
is_a: GO:1903798 ! regulation of miRNA processing
relationship: regulates GO:0031053 ! primary miRNA processing

[Term]
id: GO:2000635
name: negative regulation of primary miRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]
synonym: "negative regulation of pri-miRNA processing" EXACT [GOC:obol]
synonym: "negative regulation of primary microRNA processing" EXACT [GOC:obol]
is_a: GO:1903799 ! negative regulation of miRNA processing
is_a: GO:2000634 ! regulation of primary miRNA processing
relationship: negatively_regulates GO:0031053 ! primary miRNA processing

[Term]
id: GO:2000636
name: positive regulation of primary miRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]
synonym: "positive regulation of pri-miRNA processing" EXACT [GOC:obol]
synonym: "positive regulation of primary microRNA processing" EXACT [GOC:obol]
is_a: GO:1903800 ! positive regulation of miRNA processing
is_a: GO:2000634 ! regulation of primary miRNA processing
relationship: positively_regulates GO:0031053 ! primary miRNA processing

[Term]
id: GO:2000637
name: positive regulation of miRNA-mediated gene silencing
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA)." [GOC:dph]
synonym: "positive regulation of gene silencing by microRNA" RELATED [GOC:pr]
synonym: "positive regulation of gene silencing by miRNA" EXACT []
synonym: "positive regulation of microRNA-mediated gene silencing" EXACT [GOC:obol]
is_a: GO:0060964 ! regulation of miRNA-mediated gene silencing
is_a: GO:1900370 ! positive regulation of post-transcriptional gene silencing by RNA
relationship: positively_regulates GO:0035195 ! miRNA-mediated post-transcriptional gene silencing

[Term]
id: GO:2000638
name: regulation of SREBP signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]
synonym: "regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw]
synonym: "regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1902531 ! regulation of intracellular signal transduction
relationship: regulates GO:0032933 ! SREBP signaling pathway

[Term]
id: GO:2000639
name: negative regulation of SREBP signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]
synonym: "negative regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw]
synonym: "negative regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
is_a: GO:2000638 ! regulation of SREBP signaling pathway
relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway

[Term]
id: GO:2000640
name: positive regulation of SREBP signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]
synonym: "positive regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw]
synonym: "positive regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
is_a: GO:2000638 ! regulation of SREBP signaling pathway
relationship: positively_regulates GO:0032933 ! SREBP signaling pathway

[Term]
id: GO:2000641
name: regulation of early endosome to late endosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0045022 ! early endosome to late endosome transport

[Term]
id: GO:2000642
name: negative regulation of early endosome to late endosome transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:2000641 ! regulation of early endosome to late endosome transport
relationship: negatively_regulates GO:0045022 ! early endosome to late endosome transport

[Term]
id: GO:2000643
name: positive regulation of early endosome to late endosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:2000641 ! regulation of early endosome to late endosome transport
relationship: positively_regulates GO:0045022 ! early endosome to late endosome transport

[Term]
id: GO:2000644
name: regulation of receptor catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor catabolic process." [GOC:BHF]
synonym: "regulation of receptor breakdown" EXACT [GOC:obol]
synonym: "regulation of receptor catabolism" EXACT [GOC:obol]
synonym: "regulation of receptor degradation" EXACT [GOC:obol]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0032801 ! receptor catabolic process

[Term]
id: GO:2000645
name: negative regulation of receptor catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process." [GOC:BHF]
synonym: "negative regulation of receptor breakdown" EXACT [GOC:obol]
synonym: "negative regulation of receptor catabolism" EXACT [GOC:obol]
synonym: "negative regulation of receptor degradation" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:2000644 ! regulation of receptor catabolic process
relationship: negatively_regulates GO:0032801 ! receptor catabolic process

[Term]
id: GO:2000646
name: positive regulation of receptor catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor catabolic process." [GOC:BHF]
synonym: "positive regulation of receptor breakdown" EXACT [GOC:obol]
synonym: "positive regulation of receptor catabolism" EXACT [GOC:obol]
synonym: "positive regulation of receptor degradation" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:2000644 ! regulation of receptor catabolic process
relationship: positively_regulates GO:0032801 ! receptor catabolic process

[Term]
id: GO:2000647
name: negative regulation of stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
relationship: negatively_regulates GO:0072089 ! stem cell proliferation

[Term]
id: GO:2000648
name: positive regulation of stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
relationship: positively_regulates GO:0072089 ! stem cell proliferation

[Term]
id: GO:2000649
name: regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport

[Term]
id: GO:2000650
name: negative regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:2000651
name: positive regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity

[Term]
id: GO:2000652
name: regulation of secondary cell wall biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis." [GOC:obol]
synonym: "regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:obol]
synonym: "regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:obol]
synonym: "regulation of secondary cell wall anabolism" RELATED [GOC:obol]
synonym: "regulation of secondary cell wall biosynthetic process" RELATED [GOC:obol]
synonym: "regulation of secondary cell wall formation" RELATED [GOC:obol]
synonym: "regulation of secondary cell wall synthesis" RELATED [GOC:obol]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: regulates GO:0009834 ! plant-type secondary cell wall biogenesis

[Term]
id: GO:2000653
name: obsolete regulation of genetic imprinting
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic imprinting." [GOC:BHF]
comment: This term was obsoleted because its parent, genomic imprinting ; GO:0071514, is already a regulated process.
synonym: "regulation of DNA imprinting" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0071514

[Term]
id: GO:2000654
name: regulation of cellular response to testosterone stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0071394 ! cellular response to testosterone stimulus

[Term]
id: GO:2000655
name: negative regulation of cellular response to testosterone stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2000654 ! regulation of cellular response to testosterone stimulus
relationship: negatively_regulates GO:0071394 ! cellular response to testosterone stimulus

[Term]
id: GO:2000656
name: regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:2000657
name: negative regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:2000656 ! regulation of apolipoprotein binding

[Term]
id: GO:2000658
name: positive regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:2000656 ! regulation of apolipoprotein binding

[Term]
id: GO:2000659
name: regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]
synonym: "regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol]
synonym: "regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070498 ! interleukin-1-mediated signaling pathway

[Term]
id: GO:2000660
name: negative regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]
synonym: "negative regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway
relationship: negatively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway

[Term]
id: GO:2000661
name: positive regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]
synonym: "positive regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway
relationship: positively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway

[Term]
id: GO:2000668
name: regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
relationship: regulates GO:0097048 ! dendritic cell apoptotic process

[Term]
id: GO:2000669
name: negative regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
relationship: negatively_regulates GO:0097048 ! dendritic cell apoptotic process

[Term]
id: GO:2000670
name: positive regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
relationship: positively_regulates GO:0097048 ! dendritic cell apoptotic process

[Term]
id: GO:2000671
name: regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043523 ! regulation of neuron apoptotic process
relationship: regulates GO:0097049 ! motor neuron apoptotic process

[Term]
id: GO:2000672
name: negative regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
relationship: negatively_regulates GO:0097049 ! motor neuron apoptotic process

[Term]
id: GO:2000673
name: positive regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
relationship: positively_regulates GO:0097049 ! motor neuron apoptotic process

[Term]
id: GO:2000674
name: regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
relationship: regulates GO:0097050 ! type B pancreatic cell apoptotic process

[Term]
id: GO:2000675
name: negative regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process
relationship: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process

[Term]
id: GO:2000676
name: positive regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process
relationship: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process

[Term]
id: GO:2000677
name: regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:2000678
name: negative regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding

[Term]
id: GO:2000679
name: positive regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding

[Term]
id: GO:2000680
name: obsolete regulation of rubidium ion transport
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transport." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "regulation of Rb+ transport" EXACT [GOC:obol]
synonym: "regulation of rubidium cation transport" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000681
name: obsolete negative regulation of rubidium ion transport
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transport." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "negative regulation of Rb+ transport" EXACT [GOC:obol]
synonym: "negative regulation of rubidium cation transport" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000682
name: obsolete positive regulation of rubidium ion transport
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transport." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "positive regulation of Rb+ transport" EXACT [GOC:obol]
synonym: "positive regulation of rubidium cation transport" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000683
name: regulation of cellular response to X-ray
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to X-ray." [GOC:obol]
synonym: "regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0071481 ! cellular response to X-ray

[Term]
id: GO:2000684
name: negative regulation of cellular response to X-ray
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray." [GOC:obol]
synonym: "negative regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2000683 ! regulation of cellular response to X-ray
relationship: negatively_regulates GO:0071481 ! cellular response to X-ray

[Term]
id: GO:2000685
name: positive regulation of cellular response to X-ray
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol]
synonym: "positive regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2000683 ! regulation of cellular response to X-ray
relationship: positively_regulates GO:0071481 ! cellular response to X-ray

[Term]
id: GO:2000686
name: obsolete regulation of rubidium ion transmembrane transporter activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol]
synonym: "regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol]
synonym: "regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000687
name: obsolete negative regulation of rubidium ion transmembrane transporter activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "negative regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol]
synonym: "negative regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol]
synonym: "negative regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000688
name: obsolete positive regulation of rubidium ion transmembrane transporter activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf]
comment: This term has been obsoleted because it represents an assay, and not a physiological process.
synonym: "positive regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol]
synonym: "positive regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol]
synonym: "positive regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000689
name: actomyosin contractile ring assembly actin filament organization
namespace: biological_process
def: "An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah]
synonym: "actin filament organisation of constriction ring assembly" RELATED [GOC:obol]
synonym: "actin filament organisation of contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
synonym: "actin filament organization involved in cytokinetic actomyosin contractile ring assembly" EXACT []
synonym: "actin filament organization of constriction ring assembly" RELATED [GOC:obol]
synonym: "actin filament organization of contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of constriction ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of contractile ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
is_a: GO:0007015 ! actin filament organization
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000915 ! actomyosin contractile ring assembly

[Term]
id: GO:2000690
name: regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051890 ! regulation of cardioblast differentiation
relationship: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation

[Term]
id: GO:2000691
name: negative regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045662 ! negative regulation of myoblast differentiation
is_a: GO:0051892 ! negative regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
relationship: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation

[Term]
id: GO:2000692
name: negative regulation of seed maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation." [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000034 ! regulation of seed maturation
is_a: GO:2000242 ! negative regulation of reproductive process
relationship: negatively_regulates GO:0010431 ! seed maturation

[Term]
id: GO:2000693
name: positive regulation of seed maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of seed maturation." [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000034 ! regulation of seed maturation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0010431 ! seed maturation

[Term]
id: GO:2000694
name: regulation of phragmoplast microtubule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization." [GOC:obol]
synonym: "regulation of phragmoplast microtubule cytoskeleton organization" EXACT [GOC:obol]
synonym: "regulation of phragmoplast microtubule organisation" EXACT [GOC:mah]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0080175 ! phragmoplast microtubule organization

[Term]
id: GO:2000696
name: regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development

[Term]
id: GO:2000697
name: negative regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
relationship: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development

[Term]
id: GO:2000698
name: positive regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
relationship: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development

[Term]
id: GO:2000699
name: fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:yaf]
synonym: "FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0060676 ! ureteric bud formation

[Term]
id: GO:2000700
name: positive regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045663 ! positive regulation of myoblast differentiation
is_a: GO:0051891 ! positive regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
relationship: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation

[Term]
id: GO:2000701
name: glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway
relationship: part_of GO:0060676 ! ureteric bud formation

[Term]
id: GO:2000702
name: regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
relationship: regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

[Term]
id: GO:2000703
name: negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "negative regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
relationship: negatively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

[Term]
id: GO:2000704
name: positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "positive regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
relationship: positively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

[Term]
id: GO:2000705
name: regulation of dense core granule biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dense core granule biogenesis." [GOC:obol]
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0061110 ! dense core granule biogenesis

[Term]
id: GO:2000706
name: negative regulation of dense core granule biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis." [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000705 ! regulation of dense core granule biogenesis
relationship: negatively_regulates GO:0061110 ! dense core granule biogenesis

[Term]
id: GO:2000707
name: positive regulation of dense core granule biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis." [GOC:obol]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:2000705 ! regulation of dense core granule biogenesis
relationship: positively_regulates GO:0061110 ! dense core granule biogenesis

[Term]
id: GO:2000709
name: regulation of maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol]
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion
relationship: regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric

[Term]
id: GO:2000710
name: negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "negative regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol]
is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric
relationship: negatively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric

[Term]
id: GO:2000711
name: positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "positive regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol]
is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric
relationship: positively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric

[Term]
id: GO:2000712
name: obsolete regulation of maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000713
name: obsolete negative regulation of maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
comment: This term was added in error
synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000714
name: obsolete positive regulation of maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000715
name: regulation of maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol]
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
relationship: regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms

[Term]
id: GO:2000716
name: negative regulation of maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol]
is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms
relationship: negatively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms

[Term]
id: GO:2000717
name: positive regulation of maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol]
is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms
relationship: positively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms

[Term]
id: GO:2000718
name: regulation of maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol]
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion
relationship: regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric

[Term]
id: GO:2000719
name: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "negative regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol]
is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric
relationship: negatively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric

[Term]
id: GO:2000720
name: positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "positive regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol]
is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric
relationship: positively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric

[Term]
id: GO:2000721
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "activation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "activation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "activation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "activation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of global transcription from Pol II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of global transcription from Pol II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "up regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "up regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "upregulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "upregulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0045944
consider: GO:0051145

[Term]
id: GO:2000722
name: regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905207 ! regulation of cardiocyte differentiation
relationship: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:2000723
name: negative regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "negative regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation
relationship: negatively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:2000724
name: positive regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "positive regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation
relationship: positively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:2000725
name: regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
is_a: GO:1905207 ! regulation of cardiocyte differentiation
relationship: regulates GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:2000726
name: negative regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
relationship: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:2000727
name: positive regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
relationship: positively_regulates GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:2000728
name: regulation of mRNA export from nucleus in response to heat stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress." [PMID:15210706]
synonym: "regulation of mRNA export from cell nucleus during heat stress" EXACT [GOC:obol]
synonym: "regulation of mRNA export from nucleus during heat stress" RELATED [GOC:obol]
is_a: GO:0010793 ! regulation of mRNA export from nucleus
is_a: GO:1900034 ! regulation of cellular response to heat
relationship: regulates GO:0031990 ! mRNA export from nucleus in response to heat stress

[Term]
id: GO:2000729
name: positive regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development." [GOC:obol]
synonym: "positive regulation of ureter mesenchymal cell proliferation" RELATED [GOC:obol]
synonym: "positive regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:obol]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development
relationship: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development

[Term]
id: GO:2000730
name: regulation of termination of RNA polymerase I transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol]
synonym: "regulation of RNA polymerase I transcription termination" EXACT [GOC:obol]
synonym: "regulation of transcription termination from Pol I promoter" EXACT [GOC:obol]
synonym: "regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol]
is_a: GO:0006356 ! regulation of transcription by RNA polymerase I
is_a: GO:0031554 ! regulation of termination of DNA-templated transcription
relationship: regulates GO:0006363 ! termination of RNA polymerase I transcription

[Term]
id: GO:2000731
name: negative regulation of termination of RNA polymerase I transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol]
synonym: "negative regulation of RNA polymerase I transcription termination" EXACT [GOC:obol]
synonym: "negative regulation of transcription termination from Pol I promoter" EXACT [GOC:obol]
synonym: "negative regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol]
is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I
is_a: GO:0060567 ! negative regulation of termination of DNA-templated transcription
is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription
relationship: negatively_regulates GO:0006363 ! termination of RNA polymerase I transcription

[Term]
id: GO:2000732
name: positive regulation of termination of RNA polymerase I transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol]
synonym: "positive regulation of RNA polymerase I transcription termination" EXACT [GOC:obol]
synonym: "positive regulation of transcription termination from Pol I promoter" EXACT [GOC:obol]
synonym: "positive regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol]
is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I
is_a: GO:0060566 ! positive regulation of termination of DNA-templated transcription
is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription
relationship: positively_regulates GO:0006363 ! termination of RNA polymerase I transcription

[Term]
id: GO:2000733
name: regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol]
synonym: "regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

[Term]
id: GO:2000734
name: negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol]
synonym: "negative regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
relationship: negatively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

[Term]
id: GO:2000735
name: positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol]
synonym: "positive regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
relationship: positively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

[Term]
id: GO:2000736
name: regulation of stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0048863 ! stem cell differentiation

[Term]
id: GO:2000737
name: negative regulation of stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
relationship: negatively_regulates GO:0048863 ! stem cell differentiation

[Term]
id: GO:2000738
name: positive regulation of stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
relationship: positively_regulates GO:0048863 ! stem cell differentiation

[Term]
id: GO:2000739
name: regulation of mesenchymal stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol]
is_a: GO:2000736 ! regulation of stem cell differentiation
relationship: regulates GO:0072497 ! mesenchymal stem cell differentiation

[Term]
id: GO:2000740
name: negative regulation of mesenchymal stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol]
is_a: GO:2000737 ! negative regulation of stem cell differentiation
is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation
relationship: negatively_regulates GO:0072497 ! mesenchymal stem cell differentiation

[Term]
id: GO:2000741
name: positive regulation of mesenchymal stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol]
is_a: GO:2000738 ! positive regulation of stem cell differentiation
is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation
relationship: positively_regulates GO:0072497 ! mesenchymal stem cell differentiation

[Term]
id: GO:2000742
name: regulation of anterior head development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterior head development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0097065 ! anterior head development

[Term]
id: GO:2000743
name: negative regulation of anterior head development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterior head development." [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000742 ! regulation of anterior head development
relationship: negatively_regulates GO:0097065 ! anterior head development

[Term]
id: GO:2000744
name: positive regulation of anterior head development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterior head development." [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000742 ! regulation of anterior head development
relationship: positively_regulates GO:0097065 ! anterior head development

[Term]
id: GO:2000745
name: obsolete positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase III promoter that is involved in smooth muscle cell differentiation." [GOC:BHF]
comment: This term was made obsolete because it was added in error.
synonym: "activation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "activation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of transcription from Pol III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation" EXACT []
synonym: "positive regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "upregulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "upregulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0048665
consider: GO:0051145

[Term]
id: GO:2000746
name: regulation of defecation rhythm
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defecation rhythm." [GOC:kmv]
synonym: "regulation of defecation behavior" RELATED [GOC:obol]
synonym: "regulation of defecation cycle" EXACT [GOC:obol]
synonym: "regulation of defecation motor program" EXACT [GOC:obol]
synonym: "regulation of DMP" EXACT [GOC:obol]
is_a: GO:2000292 ! regulation of defecation
relationship: regulates GO:0035882 ! defecation rhythm

[Term]
id: GO:2000747
name: negative regulation of defecation rhythm
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm." [GOC:kmv]
synonym: "negative regulation of defecation behavior" RELATED [GOC:obol]
synonym: "negative regulation of defecation cycle" EXACT [GOC:obol]
synonym: "negative regulation of defecation motor program" EXACT [GOC:obol]
synonym: "negative regulation of DMP" EXACT [GOC:obol]
is_a: GO:2000293 ! negative regulation of defecation
is_a: GO:2000746 ! regulation of defecation rhythm
relationship: negatively_regulates GO:0035882 ! defecation rhythm

[Term]
id: GO:2000748
name: positive regulation of defecation rhythm
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defecation rhythm." [GOC:kmv]
synonym: "positive regulation of defecation behavior" RELATED [GOC:obol]
synonym: "positive regulation of defecation cycle" EXACT [GOC:obol]
synonym: "positive regulation of defecation motor program" EXACT [GOC:obol]
synonym: "positive regulation of DMP" EXACT [GOC:obol]
is_a: GO:2000294 ! positive regulation of defecation
is_a: GO:2000746 ! regulation of defecation rhythm
relationship: positively_regulates GO:0035882 ! defecation rhythm

[Term]
id: GO:2000749
name: positive regulation of rDNA heterochromatin formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of rDNA heterochromatin formation." [PMID:10899127]
synonym: "positive regulation of chromatin silencing at rDNA" BROAD []
synonym: "positive regulation of chromatin silencing at ribosomal DNA" BROAD [GOC:obol]
synonym: "positive regulation of heterochromatic silencing at rDNA" BROAD [GOC:obol]
synonym: "positive regulation of rDNA chromatin silencing" BROAD [GOC:obol]
synonym: "positive regulation of rDNA heterochromatin assembly" EXACT []
synonym: "positive regulation of ribosomal DNA heterochromatin assembly" EXACT []
is_a: GO:0031453 ! positive regulation of heterochromatin formation
is_a: GO:0061187 ! regulation of rDNA heterochromatin formation
relationship: positively_regulates GO:0000183 ! rDNA heterochromatin formation

[Term]
id: GO:2000750
name: negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:mah]
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape
relationship: negatively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape

[Term]
id: GO:2000751
name: obsolete histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
namespace: biological_process
def: "OBSOLETE. Any histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol]
comment: This term was obsoleted because it represents a molecular function.
synonym: "histone H3-T3 phosphorylation of chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol]
synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol]
synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localization to kinetochore" EXACT [GOC:obol]
synonym: "histone H3-T3 phosphorylation of CPC complex localization to kinetochore" EXACT [GOC:obol]
synonym: "histone H3-T3 phosphorylation of CPC localization to kinetochore" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0072354

[Term]
id: GO:2000752
name: regulation of glucosylceramide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF]
synonym: "regulation of glucosylceramide breakdown" EXACT [GOC:obol]
synonym: "regulation of glucosylceramide catabolism" EXACT [GOC:obol]
synonym: "regulation of glucosylceramide degradation" EXACT [GOC:obol]
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:1905038 ! regulation of membrane lipid metabolic process
relationship: regulates GO:0006680 ! glucosylceramide catabolic process

[Term]
id: GO:2000753
name: positive regulation of glucosylceramide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF]
synonym: "positive regulation of glucosylceramide breakdown" EXACT [GOC:obol]
synonym: "positive regulation of glucosylceramide catabolism" EXACT [GOC:obol]
synonym: "positive regulation of glucosylceramide degradation" EXACT [GOC:obol]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:2000752 ! regulation of glucosylceramide catabolic process
relationship: positively_regulates GO:0006680 ! glucosylceramide catabolic process

[Term]
id: GO:2000754
name: regulation of sphingomyelin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF]
synonym: "regulation of sphingomyelin breakdown" EXACT [GOC:obol]
synonym: "regulation of sphingomyelin catabolism" EXACT [GOC:obol]
synonym: "regulation of sphingomyelin degradation" EXACT [GOC:obol]
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0060696 ! regulation of phospholipid catabolic process
is_a: GO:1905038 ! regulation of membrane lipid metabolic process
relationship: regulates GO:0006685 ! sphingomyelin catabolic process

[Term]
id: GO:2000755
name: positive regulation of sphingomyelin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF]
synonym: "positive regulation of sphingomyelin breakdown" EXACT [GOC:obol]
synonym: "positive regulation of sphingomyelin catabolism" EXACT [GOC:obol]
synonym: "positive regulation of sphingomyelin degradation" EXACT [GOC:obol]
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0060697 ! positive regulation of phospholipid catabolic process
is_a: GO:2000754 ! regulation of sphingomyelin catabolic process
relationship: positively_regulates GO:0006685 ! sphingomyelin catabolic process

[Term]
id: GO:2000756
name: regulation of peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:1901983 ! regulation of protein acetylation
relationship: regulates GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:2000757
name: negative regulation of peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:1901984 ! negative regulation of protein acetylation
is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation
relationship: negatively_regulates GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:2000758
name: positive regulation of peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:1901985 ! positive regulation of protein acetylation
is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation
relationship: positively_regulates GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:2000759
name: regulation of N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:1903317 ! regulation of protein maturation
is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation
relationship: regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation

[Term]
id: GO:2000760
name: negative regulation of N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:1903318 ! negative regulation of protein maturation
is_a: GO:2000757 ! negative regulation of peptidyl-lysine acetylation
is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation
relationship: negatively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation

[Term]
id: GO:2000761
name: positive regulation of N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:1903319 ! positive regulation of protein maturation
is_a: GO:2000758 ! positive regulation of peptidyl-lysine acetylation
is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation
relationship: positively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation

[Term]
id: GO:2000762
name: regulation of phenylpropanoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phenylpropanoid metabolic process." [GOC:obol]
synonym: "regulation of phenylpropanoid metabolism" EXACT [GOC:obol]
is_a: GO:0043455 ! regulation of secondary metabolic process
relationship: regulates GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:2000763
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in norepinephrine biosynthetic process." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine anabolism" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine formation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine synthesis" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0042421
consider: GO:0045944

[Term]
id: GO:2000764
name: positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis." [GOC:BHF]
synonym: "positive regulation of semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:obol]
is_a: GO:2001262 ! positive regulation of semaphorin-plexin signaling pathway
relationship: positively_regulates GO:0071527 ! semaphorin-plexin signaling pathway involved in outflow tract morphogenesis

[Term]
id: GO:2000765
name: regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0006417 ! regulation of translation
relationship: regulates GO:0002181 ! cytoplasmic translation

[Term]
id: GO:2000766
name: negative regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:2000765 ! regulation of cytoplasmic translation
relationship: negatively_regulates GO:0002181 ! cytoplasmic translation

[Term]
id: GO:2000767
name: positive regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:2000765 ! regulation of cytoplasmic translation
relationship: positively_regulates GO:0002181 ! cytoplasmic translation

[Term]
id: GO:2000768
name: positive regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:obol]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
relationship: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation

[Term]
id: GO:2000769
name: regulation of establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah]
is_a: GO:0008360 ! regulation of cell shape
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
relationship: regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape

[Term]
id: GO:2000770
name: negative regulation of establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
relationship: negatively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape

[Term]
id: GO:2000771
name: positive regulation of establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
relationship: positively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape

[Term]
id: GO:2000772
name: regulation of cellular senescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular senescence." [GOC:BHF]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0090398 ! cellular senescence

[Term]
id: GO:2000773
name: negative regulation of cellular senescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence." [GOC:BHF]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:2000772 ! regulation of cellular senescence
relationship: negatively_regulates GO:0090398 ! cellular senescence

[Term]
id: GO:2000774
name: positive regulation of cellular senescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular senescence." [GOC:BHF]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:2000772 ! regulation of cellular senescence
relationship: positively_regulates GO:0090398 ! cellular senescence

[Term]
id: GO:2000775
name: obsolete histone H3-S10 phosphorylation involved in chromosome condensation
namespace: biological_process
def: "OBSOLETE. Any histone H3-S10 phosphorylation that is involved in chromosome condensation." [GOC:obol]
comment: This term was obsoleted because it is a molecular function represented as a biological process.
synonym: "histone H3 phosphorylation at S10 of chromosome condensation" EXACT [GOC:obol]
synonym: "histone H3-S10 phosphorylation of chromosome condensation" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000776
name: obsolete histone H4 acetylation involved in response to DNA damage stimulus
namespace: biological_process
def: "OBSOLETE. Any histone H4 acetylation that is involved in a response to DNA damage stimulus." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function and is a precomposed term.
synonym: "histone H4 acetylation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "histone H4 acetylation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "histone H4 acetylation of DNA damage response" EXACT [GOC:obol]
synonym: "histone H4 acetylation of response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "histone H4 acetylation of response to genotoxic stress" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0140861

[Term]
id: GO:2000777
name: obsolete positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
namespace: biological_process
def: "OBSOLETE. Any positive regulation of proteasomal ubiquitin-dependent protein catabolic process that is involved in a cellular response to hypoxia." [GOC:mah]
comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxic stress" EXACT [GOC:obol]
synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to lowered oxygen tension" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000779
name: regulation of double-strand break repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF]
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0006302 ! double-strand break repair

[Term]
id: GO:2000780
name: negative regulation of double-strand break repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:2000779 ! regulation of double-strand break repair
relationship: negatively_regulates GO:0006302 ! double-strand break repair

[Term]
id: GO:2000781
name: positive regulation of double-strand break repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:2000779 ! regulation of double-strand break repair
relationship: positively_regulates GO:0006302 ! double-strand break repair

[Term]
id: GO:2000782
name: regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah]
is_a: GO:2000114 ! regulation of establishment of cell polarity
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
relationship: regulates GO:0071964 ! establishment of cell polarity regulating cell shape

[Term]
id: GO:2000783
name: negative regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah]
is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape
is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape
relationship: negatively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape

[Term]
id: GO:2000784
name: positive regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah]
is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape
is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape
relationship: positively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape

[Term]
id: GO:2000785
name: regulation of autophagosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]
synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol]
synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol]
synonym: "regulation of autophagosome formation" EXACT [GOC:obol]
synonym: "regulation of PAS formation" RELATED [GOC:obol]
is_a: GO:0044088 ! regulation of vacuole organization
is_a: GO:1902115 ! regulation of organelle assembly
relationship: regulates GO:0000045 ! autophagosome assembly

[Term]
id: GO:2000786
name: positive regulation of autophagosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]
synonym: "positive regulation of autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "positive regulation of autophagic vacuole formation" RELATED [GOC:obol]
synonym: "positive regulation of autophagosome biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of autophagosome formation" EXACT [GOC:obol]
synonym: "positive regulation of PAS formation" RELATED [GOC:obol]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0044090 ! positive regulation of vacuole organization
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:2000785 ! regulation of autophagosome assembly
relationship: positively_regulates GO:0000045 ! autophagosome assembly

[Term]
id: GO:2000787
name: regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation
relationship: regulates GO:0060845 ! venous endothelial cell fate commitment

[Term]
id: GO:2000788
name: negative regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0110059 ! negative regulation of blood vessel endothelial cell differentiation
is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment
relationship: negatively_regulates GO:0060845 ! venous endothelial cell fate commitment

[Term]
id: GO:2000789
name: positive regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0110058 ! positive regulation of blood vessel endothelial cell differentiation
is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment
relationship: positively_regulates GO:0060845 ! venous endothelial cell fate commitment

[Term]
id: GO:2000790
name: regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development

[Term]
id: GO:2000791
name: negative regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
relationship: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development

[Term]
id: GO:2000792
name: positive regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
relationship: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development

[Term]
id: GO:2000793
name: cell proliferation involved in heart valve development
namespace: biological_process
def: "Any cell proliferation that is involved in heart valve development." [GOC:BHF]
synonym: "cell proliferation of cardiac valve development" EXACT [GOC:obol]
synonym: "cell proliferation of heart valve development" EXACT [GOC:obol]
is_a: GO:0008283 ! cell population proliferation
relationship: part_of GO:0003170 ! heart valve development

[Term]
id: GO:2000794
name: regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis

[Term]
id: GO:2000795
name: negative regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
relationship: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis

[Term]
id: GO:2000796
name: Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any Notch signaling pathway that is involved in negative regulation of venous endothelial cell fate commitment." [PMID:11585794]
synonym: "N signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch-receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch-receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:2000788 ! negative regulation of venous endothelial cell fate commitment

[Term]
id: GO:2000797
name: regulation of amniotic stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol]
is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation
relationship: regulates GO:0097086 ! amniotic stem cell differentiation

[Term]
id: GO:2000798
name: negative regulation of amniotic stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol]
is_a: GO:2000740 ! negative regulation of mesenchymal stem cell differentiation
is_a: GO:2000797 ! regulation of amniotic stem cell differentiation
relationship: negatively_regulates GO:0097086 ! amniotic stem cell differentiation

[Term]
id: GO:2000799
name: positive regulation of amniotic stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol]
is_a: GO:2000741 ! positive regulation of mesenchymal stem cell differentiation
is_a: GO:2000797 ! regulation of amniotic stem cell differentiation
relationship: positively_regulates GO:0097086 ! amniotic stem cell differentiation

[Term]
id: GO:2000800
name: regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF]
synonym: "regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol]
is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition
relationship: regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation

[Term]
id: GO:2000801
name: negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF]
synonym: "negative regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol]
is_a: GO:0140050 ! negative regulation of endocardial cushion to mesenchymal transition
is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
relationship: negatively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation

[Term]
id: GO:2000802
name: positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF]
synonym: "positive regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol]
is_a: GO:0140051 ! positive regulation of endocardial cushion to mesenchymal transition
is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
relationship: positively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation

[Term]
id: GO:2000803
name: obsolete endosomal signal transduction
namespace: biological_process
def: "OBSOLETE. The process in which a signal is passed on to downstream components located at the endosome. Endosomes can provide important intracellular signaling platforms and provide spatial and temporal control over signal transduction." [GOC:bf, GOC:signaling, PMID:15084302, PMID:17662591]
comment: This term does not seem to define a distinct pathway and possible annotations may be made instead to regulation of endocytosis.
synonym: "endosome-based signaling" EXACT [PMID:17662591]
synonym: "signaling cascade in endosome" RELATED [GOC:obol]
synonym: "signaling from endosome" EXACT [PMID:17662591]
synonym: "signaling pathway in endosome" RELATED [GOC:obol]
synonym: "signalling cascade in endosome" RELATED [GOC:obol]
synonym: "signalling pathway in endosome" RELATED [GOC:obol]
is_obsolete: true
replaced_by: GO:0030100

[Term]
id: GO:2000804
name: regulation of termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol]
synonym: "regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol]
synonym: "regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol]
is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription
relationship: regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled

[Term]
id: GO:2000805
name: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol]
synonym: "negative regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "negative regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol]
synonym: "negative regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol]
is_a: GO:0120191 ! negative regulation of termination of RNA polymerase II transcription
is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled
relationship: negatively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled

[Term]
id: GO:2000806
name: positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol]
synonym: "positive regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "positive regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol]
synonym: "positive regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol]
is_a: GO:1904595 ! positive regulation of termination of RNA polymerase II transcription
is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled
relationship: positively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled

[Term]
id: GO:2000807
name: regulation of synaptic vesicle clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0097091 ! synaptic vesicle clustering

[Term]
id: GO:2000808
name: negative regulation of synaptic vesicle clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:2000807 ! regulation of synaptic vesicle clustering
relationship: negatively_regulates GO:0097091 ! synaptic vesicle clustering

[Term]
id: GO:2000809
name: positive regulation of synaptic vesicle clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:2000807 ! regulation of synaptic vesicle clustering
relationship: positively_regulates GO:0097091 ! synaptic vesicle clustering

[Term]
id: GO:2000810
name: regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tight junction assembly." [GOC:BHF]
synonym: "regulation of tight junction formation" EXACT [GOC:obol]
is_a: GO:1901888 ! regulation of cell junction assembly
relationship: regulates GO:0070830 ! bicellular tight junction assembly

[Term]
id: GO:2000811
name: negative regulation of anoikis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anoikis." [GOC:obol]
synonym: "negative regulation of detachment induced cell death" EXACT [GOC:obol]
synonym: "negative regulation of suspension induced apoptosis" EXACT [GOC:obol]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000209 ! regulation of anoikis
relationship: negatively_regulates GO:0043276 ! anoikis

[Term]
id: GO:2000812
name: regulation of barbed-end actin filament capping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]
synonym: "regulation of barbed-end actin capping activity" EXACT [GOC:obol]
synonym: "regulation of barbed-end F-actin capping activity" EXACT [GOC:obol]
synonym: "regulation of plus-end actin filament capping activity" EXACT [GOC:obol]
synonym: "regulation of plus-end F-actin capping activity" EXACT [GOC:obol]
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0030834 ! regulation of actin filament depolymerization
relationship: regulates GO:0051016 ! barbed-end actin filament capping

[Term]
id: GO:2000813
name: negative regulation of barbed-end actin filament capping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]
synonym: "negative regulation of barbed-end actin capping activity" EXACT [GOC:obol]
synonym: "negative regulation of barbed-end F-actin capping activity" EXACT [GOC:obol]
synonym: "negative regulation of plus-end actin filament capping activity" EXACT [GOC:obol]
synonym: "negative regulation of plus-end F-actin capping activity" EXACT [GOC:obol]
is_a: GO:0030836 ! positive regulation of actin filament depolymerization
is_a: GO:0030838 ! positive regulation of actin filament polymerization
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:2000812 ! regulation of barbed-end actin filament capping
relationship: negatively_regulates GO:0051016 ! barbed-end actin filament capping

[Term]
id: GO:2000814
name: positive regulation of barbed-end actin filament capping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]
synonym: "positive regulation of barbed-end actin capping activity" EXACT [GOC:obol]
synonym: "positive regulation of barbed-end F-actin capping activity" EXACT [GOC:obol]
synonym: "positive regulation of plus-end actin filament capping activity" EXACT [GOC:obol]
synonym: "positive regulation of plus-end F-actin capping activity" EXACT [GOC:obol]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:2000812 ! regulation of barbed-end actin filament capping
relationship: positively_regulates GO:0051016 ! barbed-end actin filament capping

[Term]
id: GO:2000815
name: regulation of mRNA stability involved in response to oxidative stress
namespace: biological_process
def: "A process of regulation of mRNA stability that is involved in a response to oxidative stress." [GOC:obol]
is_a: GO:0010610 ! regulation of mRNA stability involved in response to stress
relationship: part_of GO:0006979 ! response to oxidative stress

[Term]
id: GO:2000816
name: negative regulation of mitotic sister chromatid separation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation." [GOC:obol]
synonym: "negative regulation of chromosome separation during mitosis" RELATED [GOC:obol]
synonym: "negative regulation of mitotic chromosome separation" RELATED [GOC:obol]
synonym: "negative regulation of mitotic sister chromatid resolution" EXACT [GOC:obol]
synonym: "negative regulation of sister chromatid separation during mitosis" EXACT [GOC:obol]
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation
is_a: GO:1905819 ! negative regulation of chromosome separation
relationship: negatively_regulates GO:0051306 ! mitotic sister chromatid separation

[Term]
id: GO:2000817
name: obsolete regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
namespace: biological_process
def: "OBSOLETE. Any regulation of histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of histone H3-T3 phosphorylation involved in chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol]
synonym: "regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol]
synonym: "regulation of histone H3-T3 phosphorylation involved in CPC complex localization to kinetochore" EXACT [GOC:obol]
synonym: "regulation of histone H3-T3 phosphorylation involved in CPC localization to kinetochore" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2000818
name: negative regulation of myoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
relationship: negatively_regulates GO:0051450 ! myoblast proliferation

[Term]
id: GO:2000819
name: regulation of nucleotide-excision repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nucleotide-excision repair." [GOC:jp, PMID:18836076]
synonym: "regulation of interstrand crosslink repair" RELATED [GOC:obol]
synonym: "regulation of intrastrand cross-link repair" RELATED [GOC:obol]
synonym: "regulation of NER" EXACT [GOC:obol]
synonym: "regulation of pyrimidine-dimer repair, DNA damage excision" EXACT [GOC:obol]
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:2000820
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
namespace: biological_process
def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of global transcription from Pol II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of global transcription from Pol II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of transcription from Pol II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of transcription from Pol II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in smooth muscle cell differentiation" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0000122
consider: GO:0051145

[Term]
id: GO:2000821
name: regulation of grooming behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of grooming behavior." [GOC:BHF]
synonym: "regulation of grooming behaviour" EXACT [GOC:obol]
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0007625 ! grooming behavior

[Term]
id: GO:2000822
name: regulation of behavioral fear response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of behavioral fear response." [GOC:BHF]
synonym: "regulation of behavioural fear response" EXACT [GOC:obol]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0050795 ! regulation of behavior
is_a: GO:1903365 ! regulation of fear response
relationship: regulates GO:0001662 ! behavioral fear response

[Term]
id: GO:2000825
name: positive regulation of androgen receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androgen receptor activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:0006357 ! regulation of transcription by RNA polymerase II
is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity
is_a: GO:2000273 ! positive regulation of signaling receptor activity

[Term]
id: GO:2000826
name: regulation of heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF]
synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
relationship: regulates GO:0003007 ! heart morphogenesis

[Term]
id: GO:2000827
name: mitochondrial RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion." [PMID:19864255]
synonym: "aberrant RNA catabolic process in mitochondria" EXACT [GOC:obol]
synonym: "aberrant RNA catabolic process in mitochondrion" EXACT [GOC:obol]
synonym: "RNA quality control in mitochondria" EXACT [GOC:obol]
synonym: "RNA quality control in mitochondrion" EXACT [GOC:obol]
synonym: "RNA surveillance in mitochondria" EXACT [GOC:obol]
is_a: GO:0000957 ! mitochondrial RNA catabolic process
is_a: GO:0071026 ! cytoplasmic RNA surveillance

[Term]
id: GO:2000828
name: regulation of parathyroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol]
synonym: "regulation of parathormone secretion" EXACT [GOC:obol]
synonym: "regulation of parathyrin secretion" EXACT [GOC:obol]
synonym: "regulation of PTH secretion" EXACT [GOC:obol]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0035898 ! parathyroid hormone secretion

[Term]
id: GO:2000829
name: negative regulation of parathyroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol]
synonym: "negative regulation of parathormone secretion" EXACT [GOC:obol]
synonym: "negative regulation of parathyrin secretion" EXACT [GOC:obol]
synonym: "negative regulation of PTH secretion" EXACT [GOC:obol]
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000828 ! regulation of parathyroid hormone secretion
relationship: negatively_regulates GO:0035898 ! parathyroid hormone secretion

[Term]
id: GO:2000830
name: positive regulation of parathyroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol]
synonym: "positive regulation of parathormone secretion" EXACT [GOC:obol]
synonym: "positive regulation of parathyrin secretion" EXACT [GOC:obol]
synonym: "positive regulation of PTH secretion" EXACT [GOC:obol]
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000828 ! regulation of parathyroid hormone secretion
relationship: positively_regulates GO:0035898 ! parathyroid hormone secretion

[Term]
id: GO:2000831
name: regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0035929 ! steroid hormone secretion

[Term]
id: GO:2000832
name: negative regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: negatively_regulates GO:0035929 ! steroid hormone secretion

[Term]
id: GO:2000833
name: positive regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: positively_regulates GO:0035929 ! steroid hormone secretion

[Term]
id: GO:2000834
name: regulation of androgen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: regulates GO:0035935 ! androgen secretion

[Term]
id: GO:2000835
name: negative regulation of androgen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
relationship: negatively_regulates GO:0035935 ! androgen secretion

[Term]
id: GO:2000836
name: positive regulation of androgen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
relationship: positively_regulates GO:0035935 ! androgen secretion

[Term]
id: GO:2000837
name: regulation of androstenedione secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androstenedione secretion." [GOC:sl]
synonym: "regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0035941 ! androstenedione secretion

[Term]
id: GO:2000838
name: negative regulation of androstenedione secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion." [GOC:sl]
synonym: "negative regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:2000837 ! regulation of androstenedione secretion
relationship: negatively_regulates GO:0035941 ! androstenedione secretion

[Term]
id: GO:2000839
name: positive regulation of androstenedione secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androstenedione secretion." [GOC:sl]
synonym: "positive regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:2000837 ! regulation of androstenedione secretion
relationship: positively_regulates GO:0035941 ! androstenedione secretion

[Term]
id: GO:2000840
name: regulation of dehydroepiandrosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl]
synonym: "regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol]
synonym: "regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol]
synonym: "regulation of DHEA secretion" EXACT [GOC:obol]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0035942 ! dehydroepiandrosterone secretion

[Term]
id: GO:2000841
name: negative regulation of dehydroepiandrosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl]
synonym: "negative regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol]
synonym: "negative regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol]
synonym: "negative regulation of DHEA secretion" EXACT [GOC:obol]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion
relationship: negatively_regulates GO:0035942 ! dehydroepiandrosterone secretion

[Term]
id: GO:2000842
name: positive regulation of dehydroepiandrosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl]
synonym: "positive regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol]
synonym: "positive regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol]
synonym: "positive regulation of DHEA secretion" EXACT [GOC:obol]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion
relationship: positively_regulates GO:0035942 ! dehydroepiandrosterone secretion

[Term]
id: GO:2000843
name: regulation of testosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of testosterone secretion." [GOC:sl]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0035936 ! testosterone secretion

[Term]
id: GO:2000844
name: negative regulation of testosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." [GOC:sl]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:2000843 ! regulation of testosterone secretion
relationship: negatively_regulates GO:0035936 ! testosterone secretion

[Term]
id: GO:2000845
name: positive regulation of testosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of testosterone secretion." [GOC:sl]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:2000843 ! regulation of testosterone secretion
relationship: positively_regulates GO:0035936 ! testosterone secretion

[Term]
id: GO:2000846
name: regulation of corticosteroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl]
synonym: "regulation of corticosteroid secretion" RELATED [GOC:obol]
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: regulates GO:0035930 ! corticosteroid hormone secretion

[Term]
id: GO:2000847
name: negative regulation of corticosteroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl]
synonym: "negative regulation of corticosteroid secretion" RELATED [GOC:obol]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
relationship: negatively_regulates GO:0035930 ! corticosteroid hormone secretion

[Term]
id: GO:2000848
name: positive regulation of corticosteroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl]
synonym: "positive regulation of corticosteroid secretion" RELATED [GOC:obol]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
relationship: positively_regulates GO:0035930 ! corticosteroid hormone secretion

[Term]
id: GO:2000849
name: regulation of glucocorticoid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucocorticoid secretion." [GOC:sl]
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
relationship: regulates GO:0035933 ! glucocorticoid secretion

[Term]
id: GO:2000850
name: negative regulation of glucocorticoid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion." [GOC:sl]
is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion
is_a: GO:2000849 ! regulation of glucocorticoid secretion
relationship: negatively_regulates GO:0035933 ! glucocorticoid secretion

[Term]
id: GO:2000851
name: positive regulation of glucocorticoid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion." [GOC:sl]
is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion
is_a: GO:2000849 ! regulation of glucocorticoid secretion
relationship: positively_regulates GO:0035933 ! glucocorticoid secretion

[Term]
id: GO:2000852
name: regulation of corticosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticosterone secretion." [GOC:sl]
is_a: GO:2000849 ! regulation of glucocorticoid secretion
relationship: regulates GO:0035934 ! corticosterone secretion

[Term]
id: GO:2000853
name: negative regulation of corticosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion." [GOC:sl]
is_a: GO:2000850 ! negative regulation of glucocorticoid secretion
is_a: GO:2000852 ! regulation of corticosterone secretion
relationship: negatively_regulates GO:0035934 ! corticosterone secretion

[Term]
id: GO:2000854
name: positive regulation of corticosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of corticosterone secretion." [GOC:sl]
is_a: GO:2000851 ! positive regulation of glucocorticoid secretion
is_a: GO:2000852 ! regulation of corticosterone secretion
relationship: positively_regulates GO:0035934 ! corticosterone secretion

[Term]
id: GO:2000855
name: regulation of mineralocorticoid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl]
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
relationship: regulates GO:0035931 ! mineralocorticoid secretion

[Term]
id: GO:2000856
name: negative regulation of mineralocorticoid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl]
is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion
is_a: GO:2000855 ! regulation of mineralocorticoid secretion
relationship: negatively_regulates GO:0035931 ! mineralocorticoid secretion

[Term]
id: GO:2000857
name: positive regulation of mineralocorticoid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl]
is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion
is_a: GO:2000855 ! regulation of mineralocorticoid secretion
relationship: positively_regulates GO:0035931 ! mineralocorticoid secretion

[Term]
id: GO:2000858
name: regulation of aldosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aldosterone secretion." [GOC:sl]
is_a: GO:2000855 ! regulation of mineralocorticoid secretion
relationship: regulates GO:0035932 ! aldosterone secretion

[Term]
id: GO:2000859
name: negative regulation of aldosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." [GOC:sl]
is_a: GO:2000856 ! negative regulation of mineralocorticoid secretion
is_a: GO:2000858 ! regulation of aldosterone secretion
relationship: negatively_regulates GO:0035932 ! aldosterone secretion

[Term]
id: GO:2000860
name: positive regulation of aldosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." [GOC:sl]
is_a: GO:2000857 ! positive regulation of mineralocorticoid secretion
is_a: GO:2000858 ! regulation of aldosterone secretion
relationship: positively_regulates GO:0035932 ! aldosterone secretion

[Term]
id: GO:2000861
name: regulation of estrogen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estrogen secretion." [GOC:sl]
synonym: "regulation of oestrogen secretion" RELATED [GOC:obol]
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: regulates GO:0035937 ! estrogen secretion

[Term]
id: GO:2000862
name: negative regulation of estrogen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion." [GOC:sl]
synonym: "negative regulation of oestrogen secretion" RELATED [GOC:obol]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000861 ! regulation of estrogen secretion
relationship: negatively_regulates GO:0035937 ! estrogen secretion

[Term]
id: GO:2000863
name: positive regulation of estrogen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estrogen secretion." [GOC:sl]
synonym: "positive regulation of oestrogen secretion" RELATED [GOC:obol]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000861 ! regulation of estrogen secretion
relationship: positively_regulates GO:0035937 ! estrogen secretion

[Term]
id: GO:2000864
name: regulation of estradiol secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estradiol secretion." [GOC:sl]
synonym: "regulation of oestradiol secretion" EXACT [GOC:obol]
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: regulates GO:0035938 ! estradiol secretion

[Term]
id: GO:2000865
name: negative regulation of estradiol secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion." [GOC:sl]
synonym: "negative regulation of oestradiol secretion" EXACT [GOC:obol]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000864 ! regulation of estradiol secretion
relationship: negatively_regulates GO:0035938 ! estradiol secretion

[Term]
id: GO:2000866
name: positive regulation of estradiol secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estradiol secretion." [GOC:sl]
synonym: "positive regulation of oestradiol secretion" EXACT [GOC:obol]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000864 ! regulation of estradiol secretion
relationship: positively_regulates GO:0035938 ! estradiol secretion

[Term]
id: GO:2000867
name: regulation of estrone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estrone secretion." [GOC:sl]
synonym: "regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol]
synonym: "regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: regulates GO:0035943 ! estrone secretion

[Term]
id: GO:2000868
name: negative regulation of estrone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion." [GOC:sl]
synonym: "negative regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol]
synonym: "negative regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000867 ! regulation of estrone secretion
relationship: negatively_regulates GO:0035943 ! estrone secretion

[Term]
id: GO:2000869
name: positive regulation of estrone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estrone secretion." [GOC:sl]
synonym: "positive regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol]
synonym: "positive regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000867 ! regulation of estrone secretion
relationship: positively_regulates GO:0035943 ! estrone secretion

[Term]
id: GO:2000870
name: regulation of progesterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [GOC:sl]
is_a: GO:2000194 ! regulation of female gonad development
is_a: GO:2000831 ! regulation of steroid hormone secretion
relationship: regulates GO:0042701 ! progesterone secretion

[Term]
id: GO:2000871
name: negative regulation of progesterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion." [GOC:sl]
is_a: GO:2000195 ! negative regulation of female gonad development
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000870 ! regulation of progesterone secretion
relationship: negatively_regulates GO:0042701 ! progesterone secretion

[Term]
id: GO:2000872
name: positive regulation of progesterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progesterone secretion." [GOC:sl]
is_a: GO:2000196 ! positive regulation of female gonad development
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000870 ! regulation of progesterone secretion
relationship: positively_regulates GO:0042701 ! progesterone secretion

[Term]
id: GO:2000873
name: obsolete regulation of histone H4 acetylation involved in response to DNA damage stimulus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H4 acetylation involved in response to DNA damage stimulus." [GOC:mah]
comment: This term was obsoleted because it represents a molecular function and is a precomposed term.
synonym: "regulation of histone H4 acetylation involved in cellular DNA damage response" EXACT [GOC:obol]
synonym: "regulation of histone H4 acetylation involved in cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "regulation of histone H4 acetylation involved in DNA damage response" EXACT [GOC:obol]
synonym: "regulation of histone H4 acetylation involved in response to DNA damage" EXACT [GOC:bf]
synonym: "regulation of histone H4 acetylation involved in response to genotoxic stress" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0140861

[Term]
id: GO:2000874
name: regulation of glyoxylate cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glyoxylate cycle." [GOC:dgf]
synonym: "regulation of glyoxylate bypass" EXACT [GOC:obol]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0006097 ! glyoxylate cycle

[Term]
id: GO:2000875
name: negative regulation of glyoxylate cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glyoxylate cycle." [GOC:dgf]
synonym: "negative regulation of glyoxylate bypass" EXACT [GOC:obol]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000874 ! regulation of glyoxylate cycle
relationship: negatively_regulates GO:0006097 ! glyoxylate cycle

[Term]
id: GO:2000876
name: positive regulation of glyoxylate cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glyoxylate cycle." [GOC:dgf]
synonym: "positive regulation of glyoxylate bypass" EXACT [GOC:obol]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2000874 ! regulation of glyoxylate cycle
relationship: positively_regulates GO:0006097 ! glyoxylate cycle

[Term]
id: GO:2000877
name: negative regulation of oligopeptide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport." [GOC:obol]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0090088 ! regulation of oligopeptide transport
relationship: negatively_regulates GO:0006857 ! oligopeptide transport

[Term]
id: GO:2000878
name: positive regulation of oligopeptide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligopeptide transport." [GOC:obol]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0090088 ! regulation of oligopeptide transport
relationship: positively_regulates GO:0006857 ! oligopeptide transport

[Term]
id: GO:2000879
name: negative regulation of dipeptide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport." [GOC:obol]
is_a: GO:0090089 ! regulation of dipeptide transport
is_a: GO:2000877 ! negative regulation of oligopeptide transport
relationship: negatively_regulates GO:0042938 ! dipeptide transport

[Term]
id: GO:2000880
name: positive regulation of dipeptide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dipeptide transport." [GOC:obol]
is_a: GO:0090089 ! regulation of dipeptide transport
is_a: GO:2000878 ! positive regulation of oligopeptide transport
relationship: positively_regulates GO:0042938 ! dipeptide transport

[Term]
id: GO:2000881
name: regulation of starch catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of starch catabolic process." [GOC:obol]
synonym: "regulation of starch breakdown" EXACT [GOC:obol]
synonym: "regulation of starch catabolism" EXACT [GOC:obol]
synonym: "regulation of starch degradation" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000904 ! regulation of starch metabolic process
relationship: regulates GO:0005983 ! starch catabolic process

[Term]
id: GO:2000882
name: negative regulation of starch catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process." [GOC:obol]
synonym: "negative regulation of starch breakdown" EXACT [GOC:obol]
synonym: "negative regulation of starch catabolism" EXACT [GOC:obol]
synonym: "negative regulation of starch degradation" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000881 ! regulation of starch catabolic process
is_a: GO:2000905 ! negative regulation of starch metabolic process
relationship: negatively_regulates GO:0005983 ! starch catabolic process

[Term]
id: GO:2000883
name: positive regulation of starch catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of starch catabolic process." [GOC:obol]
synonym: "positive regulation of starch breakdown" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolism" EXACT [GOC:obol]
synonym: "positive regulation of starch degradation" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000881 ! regulation of starch catabolic process
is_a: GO:2000906 ! positive regulation of starch metabolic process
relationship: positively_regulates GO:0005983 ! starch catabolic process

[Term]
id: GO:2000884
name: glucomannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glucomannan." [GOC:mengo_curators]
synonym: "glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010391 ! glucomannan metabolic process

[Term]
id: GO:2000885
name: galactoglucomannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a galactoglucomannan." [GOC:mengo_curators]
synonym: "galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010392 ! galactoglucomannan metabolic process

[Term]
id: GO:2000886
name: glucuronoxylan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoxylan." [GOC:mengo_curators]
synonym: "glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0045493 ! xylan catabolic process

[Term]
id: GO:2000887
name: glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoarabinoxylan." [GOC:mengo_curators]
synonym: "glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:0010414 ! glucuronoarabinoxylan metabolic process
is_a: GO:2000886 ! glucuronoxylan catabolic process
is_a: GO:2000888 ! arabinoxylan-containing compound catabolic process

[Term]
id: GO:2000888
name: arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an arabinoxylan." [GOC:mengo_curators]
synonym: "arabinoxylan catabolic process" RELATED []
synonym: "arabinoxylan catabolism" RELATED [GOC:obol]
is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process
is_a: GO:0045493 ! xylan catabolic process

[Term]
id: GO:2000889
name: cellodextrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellodextrin." [GOC:obol]
synonym: "cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:2000890
name: cellodextrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellodextrin." [GOC:mengo_curators]
synonym: "cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:1901027 ! dextrin catabolic process
is_a: GO:2000889 ! cellodextrin metabolic process

[Term]
id: GO:2000891
name: cellobiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellobiose." [GOC:mengo_curators]
synonym: "cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:2000892
name: cellobiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellobiose." [GOC:mengo_curators]
synonym: "cellobiose catabolism" EXACT [GOC:obol]
is_a: GO:0046352 ! disaccharide catabolic process
is_a: GO:2000891 ! cellobiose metabolic process

[Term]
id: GO:2000893
name: cellotriose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellotriose." [GOC:mengo_curators]
synonym: "cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:2000894
name: cellotriose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellotriose." [GOC:mengo_curators]
synonym: "cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2000893 ! cellotriose metabolic process

[Term]
id: GO:2000895
name: hemicellulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a hemicellulose." [GOC:mengo_curators]
synonym: "hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:0010410 ! hemicellulose metabolic process
is_a: GO:0044347 ! cell wall polysaccharide catabolic process

[Term]
id: GO:2000896
name: amylopectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amylopectin." [GOC:mengo_curators]
synonym: "Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:2000897
name: amylopectin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an amylopectin." [GOC:mengo_curators]
synonym: "Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:2000896 ! amylopectin metabolic process

[Term]
id: GO:2000898
name: regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "regulation of glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:2000884 ! glucomannan catabolic process

[Term]
id: GO:2000899
name: xyloglucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a xyloglucan." [GOC:mengo_curators]
synonym: "xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0010411 ! xyloglucan metabolic process
is_a: GO:2000895 ! hemicellulose catabolic process

[Term]
id: GO:2000900
name: cyclodextrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cyclodextrin." [GOC:mengo_curators]
synonym: "cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:2000901
name: cyclodextrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cyclodextrin." [GOC:mengo_curators]
synonym: "cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:1901027 ! dextrin catabolic process
is_a: GO:2000900 ! cyclodextrin metabolic process

[Term]
id: GO:2000902
name: cellooligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellooligosaccharide." [GOC:mengo_curators]
synonym: "cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:2000903
name: cellooligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellooligosaccharide." [GOC:mengo_curators]
synonym: "cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2000902 ! cellooligosaccharide metabolic process

[Term]
id: GO:2000904
name: regulation of starch metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of starch metabolic process." [GOC:obol]
synonym: "regulation of starch metabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0005982 ! starch metabolic process

[Term]
id: GO:2000905
name: negative regulation of starch metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch metabolic process." [GOC:obol]
synonym: "negative regulation of starch metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000904 ! regulation of starch metabolic process
relationship: negatively_regulates GO:0005982 ! starch metabolic process

[Term]
id: GO:2000906
name: positive regulation of starch metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of starch metabolic process." [GOC:obol]
synonym: "positive regulation of starch metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000904 ! regulation of starch metabolic process
relationship: positively_regulates GO:0005982 ! starch metabolic process

[Term]
id: GO:2000907
name: negative regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000898 ! regulation of glucomannan catabolic process
relationship: negatively_regulates GO:2000884 ! glucomannan catabolic process

[Term]
id: GO:2000908
name: positive regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:2000898 ! regulation of glucomannan catabolic process
is_a: GO:2000996 ! positive regulation of mannan catabolic process
relationship: positively_regulates GO:2000884 ! glucomannan catabolic process

[Term]
id: GO:2000909
name: regulation of sterol import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sterol import." [GOC:obol]
synonym: "regulation of sterol influx" EXACT [GOC:obol]
synonym: "regulation of sterol uptake" EXACT [GOC:obol]
is_a: GO:0032371 ! regulation of sterol transport
relationship: regulates GO:0035376 ! sterol import

[Term]
id: GO:2000910
name: negative regulation of sterol import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterol import." [GOC:obol]
synonym: "negative regulation of sterol influx" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake" EXACT [GOC:obol]
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:2000909 ! regulation of sterol import
relationship: negatively_regulates GO:0035376 ! sterol import

[Term]
id: GO:2000911
name: positive regulation of sterol import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sterol import." [GOC:obol]
synonym: "positive regulation of sterol influx" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake" EXACT [GOC:obol]
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:2000909 ! regulation of sterol import
relationship: positively_regulates GO:0035376 ! sterol import

[Term]
id: GO:2000912
name: regulation of galactoglucomannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators]
synonym: "regulation of galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:2000885 ! galactoglucomannan catabolic process

[Term]
id: GO:2000913
name: negative regulation of galactoglucomannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process
relationship: negatively_regulates GO:2000885 ! galactoglucomannan catabolic process

[Term]
id: GO:2000914
name: positive regulation of galactoglucomannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process
relationship: positively_regulates GO:2000885 ! galactoglucomannan catabolic process

[Term]
id: GO:2000915
name: regulation of glucuronoxylan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators]
synonym: "regulation of glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2001000 ! regulation of xylan catabolic process
relationship: regulates GO:2000886 ! glucuronoxylan catabolic process

[Term]
id: GO:2000916
name: negative regulation of glucuronoxylan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process
is_a: GO:2001001 ! negative regulation of xylan catabolic process
relationship: negatively_regulates GO:2000886 ! glucuronoxylan catabolic process

[Term]
id: GO:2000917
name: positive regulation of glucuronoxylan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process
is_a: GO:2001002 ! positive regulation of xylan catabolic process
relationship: positively_regulates GO:2000886 ! glucuronoxylan catabolic process

[Term]
id: GO:2000918
name: regulation of glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators]
synonym: "regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process
is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process
relationship: regulates GO:2000887 ! glucuronoarabinoxylan catabolic process

[Term]
id: GO:2000919
name: negative regulation of glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000916 ! negative regulation of glucuronoxylan catabolic process
is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process
is_a: GO:2000922 ! negative regulation of arabinoxylan-containing compound catabolic process
relationship: negatively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process

[Term]
id: GO:2000920
name: positive regulation of glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000917 ! positive regulation of glucuronoxylan catabolic process
is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process
is_a: GO:2000923 ! positive regulation of arabinoxylan-containing compound catabolic process
relationship: positively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process

[Term]
id: GO:2000921
name: regulation of arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators]
synonym: "regulation of arabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2001000 ! regulation of xylan catabolic process
relationship: regulates GO:2000888 ! arabinoxylan-containing compound catabolic process

[Term]
id: GO:2000922
name: negative regulation of arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of arabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process
is_a: GO:2001001 ! negative regulation of xylan catabolic process
relationship: negatively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process

[Term]
id: GO:2000923
name: positive regulation of arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of arabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process
is_a: GO:2001002 ! positive regulation of xylan catabolic process
relationship: positively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process

[Term]
id: GO:2000924
name: regulation of cellodextrin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:2000889 ! cellodextrin metabolic process

[Term]
id: GO:2000925
name: negative regulation of cellodextrin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
relationship: negatively_regulates GO:2000889 ! cellodextrin metabolic process

[Term]
id: GO:2000926
name: positive regulation of cellodextrin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
relationship: positively_regulates GO:2000889 ! cellodextrin metabolic process

[Term]
id: GO:2000927
name: regulation of cellodextrin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
relationship: regulates GO:2000890 ! cellodextrin catabolic process

[Term]
id: GO:2000928
name: negative regulation of cellodextrin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process
is_a: GO:2000927 ! regulation of cellodextrin catabolic process
relationship: negatively_regulates GO:2000890 ! cellodextrin catabolic process

[Term]
id: GO:2000929
name: positive regulation of cellodextrin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process
is_a: GO:2000927 ! regulation of cellodextrin catabolic process
relationship: positively_regulates GO:2000890 ! cellodextrin catabolic process

[Term]
id: GO:2000930
name: regulation of cellobiose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
relationship: regulates GO:2000891 ! cellobiose metabolic process

[Term]
id: GO:2000931
name: negative regulation of cellobiose metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000930 ! regulation of cellobiose metabolic process
relationship: negatively_regulates GO:2000891 ! cellobiose metabolic process

[Term]
id: GO:2000932
name: positive regulation of cellobiose metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000930 ! regulation of cellobiose metabolic process
relationship: positively_regulates GO:2000891 ! cellobiose metabolic process

[Term]
id: GO:2000933
name: regulation of cellotriose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:2000893 ! cellotriose metabolic process

[Term]
id: GO:2000934
name: negative regulation of cellotriose metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000933 ! regulation of cellotriose metabolic process
relationship: negatively_regulates GO:2000893 ! cellotriose metabolic process

[Term]
id: GO:2000935
name: positive regulation of cellotriose metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000933 ! regulation of cellotriose metabolic process
relationship: positively_regulates GO:2000893 ! cellotriose metabolic process

[Term]
id: GO:2000936
name: regulation of cellotriose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000933 ! regulation of cellotriose metabolic process
relationship: regulates GO:2000894 ! cellotriose catabolic process

[Term]
id: GO:2000937
name: negative regulation of cellotriose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000934 ! negative regulation of cellotriose metabolic process
is_a: GO:2000936 ! regulation of cellotriose catabolic process
relationship: negatively_regulates GO:2000894 ! cellotriose catabolic process

[Term]
id: GO:2000938
name: positive regulation of cellotriose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000935 ! positive regulation of cellotriose metabolic process
is_a: GO:2000936 ! regulation of cellotriose catabolic process
relationship: positively_regulates GO:2000894 ! cellotriose catabolic process

[Term]
id: GO:2000939
name: regulation of plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators]
synonym: "regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
relationship: regulates GO:0044348 ! plant-type cell wall cellulose catabolic process

[Term]
id: GO:2000940
name: negative regulation of plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process
is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process
relationship: negatively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process

[Term]
id: GO:2000941
name: positive regulation of plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process
is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process
relationship: positively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process

[Term]
id: GO:2000942
name: regulation of amylopectin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators]
synonym: "regulation of Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:2000896 ! amylopectin metabolic process

[Term]
id: GO:2000943
name: negative regulation of amylopectin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:2000942 ! regulation of amylopectin metabolic process
relationship: negatively_regulates GO:2000896 ! amylopectin metabolic process

[Term]
id: GO:2000944
name: positive regulation of amylopectin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:2000942 ! regulation of amylopectin metabolic process
relationship: positively_regulates GO:2000896 ! amylopectin metabolic process

[Term]
id: GO:2000945
name: regulation of amylopectin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators]
synonym: "regulation of Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:2000942 ! regulation of amylopectin metabolic process
relationship: regulates GO:2000897 ! amylopectin catabolic process

[Term]
id: GO:2000946
name: negative regulation of amylopectin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:2000882 ! negative regulation of starch catabolic process
is_a: GO:2000943 ! negative regulation of amylopectin metabolic process
is_a: GO:2000945 ! regulation of amylopectin catabolic process
relationship: negatively_regulates GO:2000897 ! amylopectin catabolic process

[Term]
id: GO:2000947
name: positive regulation of amylopectin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:2000883 ! positive regulation of starch catabolic process
is_a: GO:2000944 ! positive regulation of amylopectin metabolic process
is_a: GO:2000945 ! regulation of amylopectin catabolic process
relationship: positively_regulates GO:2000897 ! amylopectin catabolic process

[Term]
id: GO:2000948
name: regulation of xyloglucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators]
synonym: "regulation of xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0010411 ! xyloglucan metabolic process

[Term]
id: GO:2000949
name: negative regulation of xyloglucan metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000948 ! regulation of xyloglucan metabolic process
relationship: negatively_regulates GO:0010411 ! xyloglucan metabolic process

[Term]
id: GO:2000950
name: positive regulation of xyloglucan metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000948 ! regulation of xyloglucan metabolic process
relationship: positively_regulates GO:0010411 ! xyloglucan metabolic process

[Term]
id: GO:2000951
name: regulation of xyloglucan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators]
synonym: "regulation of xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:2000948 ! regulation of xyloglucan metabolic process
is_a: GO:2000988 ! regulation of hemicellulose catabolic process
relationship: regulates GO:2000899 ! xyloglucan catabolic process

[Term]
id: GO:2000952
name: negative regulation of xyloglucan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:2000949 ! negative regulation of xyloglucan metabolic process
is_a: GO:2000951 ! regulation of xyloglucan catabolic process
is_a: GO:2000989 ! negative regulation of hemicellulose catabolic process
relationship: negatively_regulates GO:2000899 ! xyloglucan catabolic process

[Term]
id: GO:2000953
name: positive regulation of xyloglucan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:2000950 ! positive regulation of xyloglucan metabolic process
is_a: GO:2000951 ! regulation of xyloglucan catabolic process
is_a: GO:2000990 ! positive regulation of hemicellulose catabolic process
relationship: positively_regulates GO:2000899 ! xyloglucan catabolic process

[Term]
id: GO:2000954
name: regulation of cyclodextrin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators]
synonym: "regulation of cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:2000900 ! cyclodextrin metabolic process

[Term]
id: GO:2000955
name: negative regulation of cyclodextrin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000954 ! regulation of cyclodextrin metabolic process
relationship: negatively_regulates GO:2000900 ! cyclodextrin metabolic process

[Term]
id: GO:2000956
name: positive regulation of cyclodextrin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000954 ! regulation of cyclodextrin metabolic process
relationship: positively_regulates GO:2000900 ! cyclodextrin metabolic process

[Term]
id: GO:2000957
name: regulation of cyclodextrin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators]
synonym: "regulation of cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000954 ! regulation of cyclodextrin metabolic process
relationship: regulates GO:2000901 ! cyclodextrin catabolic process

[Term]
id: GO:2000958
name: negative regulation of cyclodextrin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000955 ! negative regulation of cyclodextrin metabolic process
is_a: GO:2000957 ! regulation of cyclodextrin catabolic process
relationship: negatively_regulates GO:2000901 ! cyclodextrin catabolic process

[Term]
id: GO:2000959
name: positive regulation of cyclodextrin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000956 ! positive regulation of cyclodextrin metabolic process
is_a: GO:2000957 ! regulation of cyclodextrin catabolic process
relationship: positively_regulates GO:2000901 ! cyclodextrin catabolic process

[Term]
id: GO:2000960
name: regulation of cellooligosaccharide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
relationship: regulates GO:2000902 ! cellooligosaccharide metabolic process

[Term]
id: GO:2000961
name: negative regulation of cellooligosaccharide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process
relationship: negatively_regulates GO:2000902 ! cellooligosaccharide metabolic process

[Term]
id: GO:2000962
name: positive regulation of cellooligosaccharide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process
relationship: positively_regulates GO:2000902 ! cellooligosaccharide metabolic process

[Term]
id: GO:2000963
name: regulation of cellooligosaccharide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process
relationship: regulates GO:2000903 ! cellooligosaccharide catabolic process

[Term]
id: GO:2000964
name: negative regulation of cellooligosaccharide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000961 ! negative regulation of cellooligosaccharide metabolic process
is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process
relationship: negatively_regulates GO:2000903 ! cellooligosaccharide catabolic process

[Term]
id: GO:2000965
name: positive regulation of cellooligosaccharide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000962 ! positive regulation of cellooligosaccharide metabolic process
is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process
relationship: positively_regulates GO:2000903 ! cellooligosaccharide catabolic process

[Term]
id: GO:2000966
name: regulation of cell wall polysaccharide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators]
synonym: "regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0044347 ! cell wall polysaccharide catabolic process

[Term]
id: GO:2000967
name: negative regulation of cell wall polysaccharide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
relationship: negatively_regulates GO:0044347 ! cell wall polysaccharide catabolic process

[Term]
id: GO:2000968
name: positive regulation of cell wall polysaccharide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
relationship: positively_regulates GO:0044347 ! cell wall polysaccharide catabolic process

[Term]
id: GO:2000969
name: positive regulation of AMPA receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity." [PMID:21423165]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" BROAD []
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:2000273 ! positive regulation of signaling receptor activity
is_a: GO:2000311 ! regulation of AMPA receptor activity

[Term]
id: GO:2000970
name: regulation of detection of glucose
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of detection of glucose." [GOC:BHF]
synonym: "regulation of glucose detection" EXACT [GOC:obol]
synonym: "regulation of glucose perception" RELATED [GOC:obol]
synonym: "regulation of glucose sensing" RELATED [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0051594 ! detection of glucose

[Term]
id: GO:2000971
name: negative regulation of detection of glucose
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose." [GOC:BHF]
synonym: "negative regulation of glucose detection" EXACT [GOC:obol]
synonym: "negative regulation of glucose perception" RELATED [GOC:obol]
synonym: "negative regulation of glucose sensing" RELATED [GOC:obol]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2000970 ! regulation of detection of glucose
relationship: negatively_regulates GO:0051594 ! detection of glucose

[Term]
id: GO:2000972
name: positive regulation of detection of glucose
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of detection of glucose." [GOC:BHF]
synonym: "positive regulation of glucose detection" EXACT [GOC:obol]
synonym: "positive regulation of glucose perception" RELATED [GOC:obol]
synonym: "positive regulation of glucose sensing" RELATED [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2000970 ! regulation of detection of glucose
relationship: positively_regulates GO:0051594 ! detection of glucose

[Term]
id: GO:2000973
name: regulation of pro-B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pro-B cell differentiation." [GOC:obol]
synonym: "regulation of pro-B cell development" RELATED [GOC:obol]
synonym: "regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
relationship: regulates GO:0002328 ! pro-B cell differentiation

[Term]
id: GO:2000974
name: negative regulation of pro-B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation." [GOC:obol]
synonym: "negative regulation of pro-B cell development" RELATED [GOC:obol]
synonym: "negative regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation
is_a: GO:2000973 ! regulation of pro-B cell differentiation
relationship: negatively_regulates GO:0002328 ! pro-B cell differentiation

[Term]
id: GO:2000975
name: positive regulation of pro-B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation." [GOC:obol]
synonym: "positive regulation of pro-B cell development" RELATED [GOC:obol]
synonym: "positive regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation
is_a: GO:2000973 ! regulation of pro-B cell differentiation
relationship: positively_regulates GO:0002328 ! pro-B cell differentiation

[Term]
id: GO:2000976
name: obsolete regulation of transcription from RNA polymerase II promoter involved in detection of glucose
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in detection of glucose." [GOC:BHF]
comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "global transcription regulation from Pol II promoter involved in detection of glucose" RELATED [GOC:obol]
synonym: "global transcription regulation from Pol II promoter involved in glucose detection" RELATED [GOC:obol]
synonym: "global transcription regulation from Pol II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "global transcription regulation from Pol II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in detection of glucose" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose detection" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in detection of glucose" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in glucose detection" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in detection of glucose" EXACT [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in glucose detection" EXACT [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose detection" EXACT [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in detection of glucose" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose detection" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose sensing" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0006357
consider: GO:0051594

[Term]
id: GO:2000977
name: regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:2000978
name: negative regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:2000977 ! regulation of forebrain neuron differentiation
relationship: negatively_regulates GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:2000979
name: positive regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:2000977 ! regulation of forebrain neuron differentiation
relationship: positively_regulates GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:2000980
name: regulation of inner ear receptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol]
synonym: "regulation of inner ear hair cell differentiation" EXACT [GOC:obol]
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
relationship: regulates GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:2000981
name: negative regulation of inner ear receptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol]
synonym: "negative regulation of inner ear hair cell differentiation" EXACT [GOC:obol]
is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation
is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation
relationship: negatively_regulates GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:2000982
name: positive regulation of inner ear receptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol]
synonym: "positive regulation of inner ear hair cell differentiation" EXACT [GOC:obol]
is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation
is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation
relationship: positively_regulates GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:2000983
name: regulation of ATP citrate synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol]
synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol]
synonym: "regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol]
synonym: "regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP-citric lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol]
synonym: "regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol]
synonym: "regulation of citrate cleavage enzyme activity" RELATED [GOC:obol]
synonym: "regulation of citrate-ATP lyase activity" EXACT [GOC:obol]
synonym: "regulation of citric cleavage enzyme activity" RELATED [GOC:obol]
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:2000984
name: negative regulation of ATP citrate synthase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol]
synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol]
synonym: "negative regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol]
synonym: "negative regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP-citric lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol]
synonym: "negative regulation of citrate cleavage enzyme activity" RELATED [GOC:obol]
synonym: "negative regulation of citrate-ATP lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of citric cleavage enzyme activity" RELATED [GOC:obol]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:2000983 ! regulation of ATP citrate synthase activity

[Term]
id: GO:2000985
name: positive regulation of ATP citrate synthase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol]
synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol]
synonym: "positive regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol]
synonym: "positive regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP-citric lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol]
synonym: "positive regulation of citrate cleavage enzyme activity" RELATED [GOC:obol]
synonym: "positive regulation of citrate-ATP lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of citric cleavage enzyme activity" RELATED [GOC:obol]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:2000983 ! regulation of ATP citrate synthase activity

[Term]
id: GO:2000986
name: negative regulation of behavioral fear response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of behavioral fear response." [GOC:obol]
synonym: "negative regulation of behavioural fear response" EXACT [GOC:obol]
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1903366 ! negative regulation of fear response
is_a: GO:2000822 ! regulation of behavioral fear response
relationship: negatively_regulates GO:0001662 ! behavioral fear response

[Term]
id: GO:2000987
name: positive regulation of behavioral fear response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of behavioral fear response." [GOC:obol]
synonym: "positive regulation of behavioural fear response" EXACT [GOC:obol]
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1903367 ! positive regulation of fear response
is_a: GO:2000822 ! regulation of behavioral fear response
relationship: positively_regulates GO:0001662 ! behavioral fear response

[Term]
id: GO:2000988
name: regulation of hemicellulose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators]
synonym: "regulation of hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
relationship: regulates GO:2000895 ! hemicellulose catabolic process

[Term]
id: GO:2000989
name: negative regulation of hemicellulose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process
is_a: GO:2000988 ! regulation of hemicellulose catabolic process
relationship: negatively_regulates GO:2000895 ! hemicellulose catabolic process

[Term]
id: GO:2000990
name: positive regulation of hemicellulose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process
is_a: GO:2000988 ! regulation of hemicellulose catabolic process
relationship: positively_regulates GO:2000895 ! hemicellulose catabolic process

[Term]
id: GO:2000991
name: regulation of galactomannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0051682 ! galactomannan catabolic process

[Term]
id: GO:2000992
name: negative regulation of galactomannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000991 ! regulation of galactomannan catabolic process
relationship: negatively_regulates GO:0051682 ! galactomannan catabolic process

[Term]
id: GO:2000993
name: positive regulation of galactomannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000991 ! regulation of galactomannan catabolic process
relationship: positively_regulates GO:0051682 ! galactomannan catabolic process

[Term]
id: GO:2000994
name: regulation of mannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators]
synonym: "regulation of mannan breakdown" EXACT [GOC:obol]
synonym: "regulation of mannan catabolism" EXACT [GOC:obol]
synonym: "regulation of mannan degradation" EXACT [GOC:obol]
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
relationship: regulates GO:0046355 ! mannan catabolic process

[Term]
id: GO:2000995
name: negative regulation of mannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of mannan breakdown" EXACT [GOC:obol]
synonym: "negative regulation of mannan catabolism" EXACT [GOC:obol]
synonym: "negative regulation of mannan degradation" EXACT [GOC:obol]
is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process
is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process
is_a: GO:2000994 ! regulation of mannan catabolic process
relationship: negatively_regulates GO:0046355 ! mannan catabolic process

[Term]
id: GO:2000996
name: positive regulation of mannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of mannan breakdown" EXACT [GOC:obol]
synonym: "positive regulation of mannan catabolism" EXACT [GOC:obol]
synonym: "positive regulation of mannan degradation" EXACT [GOC:obol]
is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process
is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process
is_a: GO:2000994 ! regulation of mannan catabolic process
relationship: positively_regulates GO:0046355 ! mannan catabolic process

[Term]
id: GO:2000997
name: regulation of cellulose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellulose breakdown" EXACT [GOC:obol]
synonym: "regulation of cellulose catabolism" EXACT [GOC:obol]
synonym: "regulation of cellulose degradation" EXACT [GOC:obol]
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0030245 ! cellulose catabolic process

[Term]
id: GO:2000998
name: negative regulation of cellulose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellulose breakdown" EXACT [GOC:obol]
synonym: "negative regulation of cellulose catabolism" EXACT [GOC:obol]
synonym: "negative regulation of cellulose degradation" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000997 ! regulation of cellulose catabolic process
relationship: negatively_regulates GO:0030245 ! cellulose catabolic process

[Term]
id: GO:2000999
name: positive regulation of cellulose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellulose breakdown" EXACT [GOC:obol]
synonym: "positive regulation of cellulose catabolism" EXACT [GOC:obol]
synonym: "positive regulation of cellulose degradation" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000997 ! regulation of cellulose catabolic process
relationship: positively_regulates GO:0030245 ! cellulose catabolic process

[Term]
id: GO:2001000
name: regulation of xylan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators]
synonym: "regulation of xylan breakdown" EXACT [GOC:obol]
synonym: "regulation of xylan catabolism" EXACT [GOC:obol]
synonym: "regulation of xylan degradation" EXACT [GOC:obol]
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
is_a: GO:2000988 ! regulation of hemicellulose catabolic process
relationship: regulates GO:0045493 ! xylan catabolic process

[Term]
id: GO:2001001
name: negative regulation of xylan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of xylan breakdown" EXACT [GOC:obol]
synonym: "negative regulation of xylan catabolism" EXACT [GOC:obol]
synonym: "negative regulation of xylan degradation" EXACT [GOC:obol]
is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process
is_a: GO:2000989 ! negative regulation of hemicellulose catabolic process
is_a: GO:2001000 ! regulation of xylan catabolic process
relationship: negatively_regulates GO:0045493 ! xylan catabolic process

[Term]
id: GO:2001002
name: positive regulation of xylan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of xylan breakdown" EXACT [GOC:obol]
synonym: "positive regulation of xylan catabolism" EXACT [GOC:obol]
synonym: "positive regulation of xylan degradation" EXACT [GOC:obol]
is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process
is_a: GO:2000990 ! positive regulation of hemicellulose catabolic process
is_a: GO:2001000 ! regulation of xylan catabolic process
relationship: positively_regulates GO:0045493 ! xylan catabolic process

[Term]
id: GO:2001003
name: regulation of pectin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators]
synonym: "regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "regulation of pectin degradation" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0045490 ! pectin catabolic process

[Term]
id: GO:2001004
name: negative regulation of pectin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "negative regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "negative regulation of pectin degradation" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2001003 ! regulation of pectin catabolic process
relationship: negatively_regulates GO:0045490 ! pectin catabolic process

[Term]
id: GO:2001005
name: positive regulation of pectin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "positive regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "positive regulation of pectin degradation" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2001003 ! regulation of pectin catabolic process
relationship: positively_regulates GO:0045490 ! pectin catabolic process

[Term]
id: GO:2001006
name: regulation of cellulose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "regulation of cellulose anabolism" EXACT [GOC:obol]
synonym: "regulation of cellulose biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellulose formation" EXACT [GOC:obol]
synonym: "regulation of cellulose synthesis" EXACT [GOC:obol]
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
relationship: regulates GO:0030244 ! cellulose biosynthetic process

[Term]
id: GO:2001007
name: negative regulation of cellulose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "negative regulation of cellulose anabolism" EXACT [GOC:obol]
synonym: "negative regulation of cellulose biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellulose formation" EXACT [GOC:obol]
synonym: "negative regulation of cellulose synthesis" EXACT [GOC:obol]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2001006 ! regulation of cellulose biosynthetic process
relationship: negatively_regulates GO:0030244 ! cellulose biosynthetic process

[Term]
id: GO:2001008
name: positive regulation of cellulose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "positive regulation of cellulose anabolism" EXACT [GOC:obol]
synonym: "positive regulation of cellulose biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellulose formation" EXACT [GOC:obol]
synonym: "positive regulation of cellulose synthesis" EXACT [GOC:obol]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2001006 ! regulation of cellulose biosynthetic process
relationship: positively_regulates GO:0030244 ! cellulose biosynthetic process

[Term]
id: GO:2001009
name: regulation of plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:2001006 ! regulation of cellulose biosynthetic process
relationship: regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process

[Term]
id: GO:2001010
name: negative regulation of plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "negative regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol]
is_a: GO:2001007 ! negative regulation of cellulose biosynthetic process
is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process
relationship: negatively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process

[Term]
id: GO:2001011
name: positive regulation of plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "positive regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:2001008 ! positive regulation of cellulose biosynthetic process
is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process
relationship: positively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process

[Term]
id: GO:2001012
name: mesenchymal cell differentiation involved in renal system development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "mesenchymal cell differentiation involved in urinary system development" RELATED [GOC:obol]
synonym: "mesenchymal cell differentiation involved in urinary tract development" RELATED [GOC:obol]
is_a: GO:0048762 ! mesenchymal cell differentiation
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:2001013
name: epithelial cell proliferation involved in renal tubule morphogenesis
namespace: biological_process
def: "Any epithelial cell proliferation that is involved in renal tubule morphogenesis." [GOC:obol]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0061333 ! renal tubule morphogenesis

[Term]
id: GO:2001014
name: regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0035914 ! skeletal muscle cell differentiation

[Term]
id: GO:2001015
name: negative regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
relationship: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation

[Term]
id: GO:2001016
name: positive regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
relationship: positively_regulates GO:0035914 ! skeletal muscle cell differentiation

[Term]
id: GO:2001017
name: regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0008090 ! retrograde axonal transport

[Term]
id: GO:2001018
name: negative regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "negative regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
relationship: negatively_regulates GO:0008090 ! retrograde axonal transport

[Term]
id: GO:2001019
name: positive regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "positive regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
relationship: positively_regulates GO:0008090 ! retrograde axonal transport

[Term]
id: GO:2001020
name: obsolete regulation of response to DNA damage stimulus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
comment: The reason for obsoletion is that the meaning of the term is ambiguous; genes annotated to these terms all seem to be part of the response.
synonym: "regulation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "regulation of DNA damage response" EXACT [GOC:obol]
synonym: "regulation of response to genotoxic stress" EXACT [GOC:obol]
is_obsolete: true
replaced_by: GO:0006974

[Term]
id: GO:2001021
name: obsolete negative regulation of response to DNA damage stimulus
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
comment: The reason for obsoletion is that the meaning of the term is ambiguous; genes annotated to these terms all seem to be part of the response.
synonym: "negative regulation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "negative regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "negative regulation of DNA damage response" EXACT [GOC:obol]
synonym: "negative regulation of response to genotoxic stress" EXACT [GOC:obol]
is_obsolete: true
replaced_by: GO:0006974

[Term]
id: GO:2001022
name: obsolete positive regulation of response to DNA damage stimulus
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
comment: The reason for obsoletion is that the meaning of the term is ambiguous; genes annotated to these terms all seem to be part of the response.
synonym: "positive regulation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "positive regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "positive regulation of DNA damage response" EXACT [GOC:obol]
synonym: "positive regulation of response to genotoxic stress" EXACT [GOC:obol]
is_obsolete: true
replaced_by: GO:0006974

[Term]
id: GO:2001023
name: regulation of response to drug
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol]
synonym: "regulation of drug resistance" RELATED [GOC:obol]
synonym: "regulation of drug susceptibility/resistance" RELATED [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009410 ! response to xenobiotic stimulus

[Term]
id: GO:2001024
name: negative regulation of response to drug
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to drug." [GOC:obol]
synonym: "negative regulation of drug resistance" RELATED [GOC:obol]
synonym: "negative regulation of drug susceptibility/resistance" RELATED [GOC:obol]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2001023 ! regulation of response to drug
relationship: negatively_regulates GO:0009410 ! response to xenobiotic stimulus

[Term]
id: GO:2001025
name: positive regulation of response to drug
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to drug." [GOC:obol]
synonym: "positive regulation of drug resistance" RELATED [GOC:obol]
synonym: "positive regulation of drug susceptibility/resistance" RELATED [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2001023 ! regulation of response to drug
relationship: positively_regulates GO:0009410 ! response to xenobiotic stimulus

[Term]
id: GO:2001026
name: regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0035767 ! endothelial cell chemotaxis

[Term]
id: GO:2001027
name: negative regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
relationship: negatively_regulates GO:0035767 ! endothelial cell chemotaxis

[Term]
id: GO:2001028
name: positive regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
relationship: positively_regulates GO:0035767 ! endothelial cell chemotaxis

[Term]
id: GO:2001029
name: regulation of cellular glucuronidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular glucuronidation." [GOC:BHF]
synonym: "regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
relationship: regulates GO:0052695 ! cellular glucuronidation

[Term]
id: GO:2001030
name: negative regulation of cellular glucuronidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation." [GOC:BHF]
synonym: "negative regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol]
synonym: "negative regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2001029 ! regulation of cellular glucuronidation
relationship: negatively_regulates GO:0052695 ! cellular glucuronidation

[Term]
id: GO:2001031
name: positive regulation of cellular glucuronidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular glucuronidation." [GOC:BHF]
synonym: "positive regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2001029 ! regulation of cellular glucuronidation
relationship: positively_regulates GO:0052695 ! cellular glucuronidation

[Term]
id: GO:2001032
name: regulation of double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol]
synonym: "regulation of NHEJ" EXACT [GOC:obol]
is_a: GO:2000779 ! regulation of double-strand break repair
relationship: regulates GO:0006303 ! double-strand break repair via nonhomologous end joining

[Term]
id: GO:2001033
name: negative regulation of double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol]
synonym: "negative regulation of NHEJ" EXACT [GOC:obol]
is_a: GO:2000780 ! negative regulation of double-strand break repair
is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining
relationship: negatively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining

[Term]
id: GO:2001034
name: positive regulation of double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol]
synonym: "positive regulation of NHEJ" EXACT [GOC:obol]
is_a: GO:2000781 ! positive regulation of double-strand break repair
is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining
relationship: positively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining

[Term]
id: GO:2001035
name: regulation of tongue muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol]
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
relationship: regulates GO:0035981 ! tongue muscle cell differentiation

[Term]
id: GO:2001036
name: negative regulation of tongue muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol]
is_a: GO:1902810 ! negative regulation of skeletal muscle fiber differentiation
is_a: GO:2001035 ! regulation of tongue muscle cell differentiation
relationship: negatively_regulates GO:0035981 ! tongue muscle cell differentiation

[Term]
id: GO:2001037
name: positive regulation of tongue muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol]
is_a: GO:1902811 ! positive regulation of skeletal muscle fiber differentiation
is_a: GO:2001035 ! regulation of tongue muscle cell differentiation
relationship: positively_regulates GO:0035981 ! tongue muscle cell differentiation

[Term]
id: GO:2001038
name: regulation of cellular response to drug
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to drug." [GOC:obol]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:2001023 ! regulation of response to drug
relationship: regulates GO:0071466 ! cellular response to xenobiotic stimulus

[Term]
id: GO:2001039
name: negative regulation of cellular response to drug
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to drug." [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2001024 ! negative regulation of response to drug
is_a: GO:2001038 ! regulation of cellular response to drug
relationship: negatively_regulates GO:0071466 ! cellular response to xenobiotic stimulus

[Term]
id: GO:2001040
name: positive regulation of cellular response to drug
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to drug." [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2001025 ! positive regulation of response to drug
is_a: GO:2001038 ! regulation of cellular response to drug
relationship: positively_regulates GO:0071466 ! cellular response to xenobiotic stimulus

[Term]
id: GO:2001042
name: negative regulation of septum digestion after cytokinesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "negative regulation of cytokinetic cell separation" EXACT []
is_a: GO:0010590 ! regulation of septum digestion after cytokinesis
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0000920 ! septum digestion after cytokinesis

[Term]
id: GO:2001043
name: positive regulation of septum digestion after cytokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "positive regulation of cell separation after cytokinesis" RELATED []
synonym: "positive regulation of cytokinetic cell separation" RELATED []
is_a: GO:0010590 ! regulation of septum digestion after cytokinesis
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0000920 ! septum digestion after cytokinesis

[Term]
id: GO:2001044
name: regulation of integrin-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
synonym: "regulation of integrin-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007229 ! integrin-mediated signaling pathway

[Term]
id: GO:2001045
name: negative regulation of integrin-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
synonym: "negative regulation of integrin-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway
relationship: negatively_regulates GO:0007229 ! integrin-mediated signaling pathway

[Term]
id: GO:2001046
name: positive regulation of integrin-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
synonym: "positive regulation of integrin-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway
relationship: positively_regulates GO:0007229 ! integrin-mediated signaling pathway

[Term]
id: GO:2001049
name: regulation of tendon cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tendon cell differentiation." [GOC:obol]
synonym: "regulation of muscle attachment cell differentiation" EXACT [GOC:obol]
synonym: "regulation of tenocyte differentiation" RELATED [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0035990 ! tendon cell differentiation

[Term]
id: GO:2001050
name: negative regulation of tendon cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation." [GOC:obol]
synonym: "negative regulation of muscle attachment cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of tenocyte differentiation" RELATED [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2001049 ! regulation of tendon cell differentiation
relationship: negatively_regulates GO:0035990 ! tendon cell differentiation

[Term]
id: GO:2001051
name: positive regulation of tendon cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tendon cell differentiation." [GOC:obol]
synonym: "positive regulation of muscle attachment cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of tenocyte differentiation" RELATED [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2001049 ! regulation of tendon cell differentiation
relationship: positively_regulates GO:0035990 ! tendon cell differentiation

[Term]
id: GO:2001053
name: regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0097152 ! mesenchymal cell apoptotic process

[Term]
id: GO:2001054
name: negative regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
relationship: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process

[Term]
id: GO:2001055
name: positive regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
relationship: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process

[Term]
id: GO:2001056
name: positive regulation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol]
synonym: "positive regulation of thiol endopeptidase activity" EXACT [GOC:obol]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity

[Term]
id: GO:2001057
name: reactive nitrogen species metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a reactive nitrogen species." [GOC:obol]
synonym: "reactive nitrogen species metabolism" EXACT [GOC:obol]
synonym: "RNS metabolic process" EXACT [GOC:obol]
synonym: "RNS metabolism" EXACT [GOC:obol]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:2001058
name: D-tagatose 6-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a D-tagatose 6-phosphate." [GOC:obol]
synonym: "D-tagatose 6-phosphate metabolism" EXACT [GOC:obol]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:2001059
name: D-tagatose 6-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a D-tagatose 6-phosphate." [GOC:mengo_curators]
synonym: "D-tagatose 6-phosphate catabolism" EXACT [GOC:obol]
xref: UniPathway:UPA00704
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:2001058 ! D-tagatose 6-phosphate metabolic process

[Term]
id: GO:2001060
name: D-glycero-D-manno-heptose 7-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators]
synonym: "D-glycero-D-manno-heptose 7-phosphate metabolism" EXACT [GOC:obol]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:2001061
name: D-glycero-D-manno-heptose 7-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators]
synonym: "D-glycero-D-manno-heptose 7-phosphate biosynthesis" EXACT [GOC:obol]
xref: UniPathway:UPA00041
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:2001060 ! D-glycero-D-manno-heptose 7-phosphate metabolic process

[Term]
id: GO:2001062
name: xylan binding
namespace: molecular_function
def: "Binding to xylan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001063
name: glucomannan binding
namespace: molecular_function
def: "Binding to glucomannan." [GOC:mengo_curators]
is_a: GO:0010297 ! heteropolysaccharide binding

[Term]
id: GO:2001064
name: cellooligosaccharide binding
namespace: molecular_function
def: "Binding to cellooligosaccharide." [GOC:mengo_curators]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:2001065
name: mannan binding
namespace: molecular_function
def: "Binding to mannan." [GOC:mengo_curators]
synonym: "mannoglycan binding" RELATED [GOC:obol]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001066
name: amylopectin binding
namespace: molecular_function
def: "Binding to amylopectin." [GOC:mengo_curators]
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:2001067
name: pullulan binding
namespace: molecular_function
def: "Binding to pullulan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001068
name: arabinoxylan binding
namespace: molecular_function
def: "Binding to arabinoxylan." [GOC:mengo_curators]
is_a: GO:2001062 ! xylan binding

[Term]
id: GO:2001069
name: glycogen binding
namespace: molecular_function
def: "Binding to glycogen." [GOC:mengo_curators]
synonym: "animal starch binding" RELATED [GOC:obol]
synonym: "liver starch binding" RELATED [GOC:obol]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001070
name: starch binding
namespace: molecular_function
def: "Binding to starch." [GOC:mengo_curators]
synonym: "amidon binding" RELATED [GOC:obol]
synonym: "amylum binding" RELATED [GOC:obol]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001071
name: maltoheptaose binding
namespace: molecular_function
def: "Binding to maltoheptaose." [GOC:mengo_curators]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:2001072
name: galactomannan binding
namespace: molecular_function
def: "Binding to galactomannan." [GOC:mengo_curators]
is_a: GO:0010297 ! heteropolysaccharide binding

[Term]
id: GO:2001073
name: cyclodextrin binding
namespace: molecular_function
def: "Binding to cyclodextrin." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:2001074
name: regulation of metanephric ureteric bud development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol]
is_a: GO:0072215 ! regulation of metanephros development
relationship: regulates GO:0035502 ! metanephric part of ureteric bud development

[Term]
id: GO:2001075
name: negative regulation of metanephric ureteric bud development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2001074 ! regulation of metanephric ureteric bud development
relationship: negatively_regulates GO:0035502 ! metanephric part of ureteric bud development

[Term]
id: GO:2001076
name: positive regulation of metanephric ureteric bud development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2001074 ! regulation of metanephric ureteric bud development
relationship: positively_regulates GO:0035502 ! metanephric part of ureteric bud development

[Term]
id: GO:2001077
name: (1->3),(1->4)-beta-glucan binding
namespace: molecular_function
def: "Binding to (1->3),(1->4)-beta-glucan." [GOC:mengo_curators]
synonym: "(1,3),(1,4)-beta-glucan binding" EXACT []
synonym: "1->3,1->4-beta-glucan binding" EXACT []
synonym: "beta-(1,3),(1,4)-glucan binding" EXACT []
synonym: "beta-(1->3),(1->4)-glucan binding" EXACT []
synonym: "beta-1,3-1,4-glucan binding" EXACT []
synonym: "beta-1->3,1->4-glucan binding" EXACT []
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001078
name: (1->6)-beta-D-glucan binding
namespace: molecular_function
def: "Binding to (1->6)-beta-D-glucan." [GOC:mengo_curators]
synonym: "(1,6)-beta-D-glucan binding" EXACT []
synonym: "1,6-beta-D-glucan binding" EXACT []
synonym: "1->6-beta-D-glucan binding" EXACT []
synonym: "beta-(1,6)-D-glucan binding" EXACT []
synonym: "beta-(1->6)-D-glucan binding" EXACT []
synonym: "beta-1,6-D-glucan binding" EXACT []
synonym: "beta-1->6-D-glucan binding" EXACT []
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001079
name: beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding
namespace: molecular_function
def: "Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc." [GOC:mengo_curators]
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:2001080
name: chitosan binding
namespace: molecular_function
def: "Binding to chitosan." [GOC:mengo_curators]
is_a: GO:0043169 ! cation binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:2001081
name: (1->4)-beta-D-galactan binding
namespace: molecular_function
def: "Binding to (1->4)-beta-D-galactan." [GOC:mengo_curators]
synonym: "(1,4)-beta-D-galactan binding" EXACT []
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001082
name: inulin binding
namespace: molecular_function
def: "Binding to inulin." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001083
name: alpha-D-glucan binding
namespace: molecular_function
def: "Binding to alpha-D-glucan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001084
name: L-arabinofuranose binding
namespace: molecular_function
def: "Binding to L-arabinofuranose." [GOC:mengo_curators]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:2001085
name: arabinogalactan binding
namespace: molecular_function
def: "Binding to arabinogalactan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:2001086
name: obsolete laminarabiose transport
namespace: biological_process
def: "OBSOLETE. The directed movement of a laminarabioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
comment: This term has been obsoleted because it does not represent an evolved process.
is_obsolete: true

[Term]
id: GO:2001087
name: sophorose transport
namespace: biological_process
def: "The directed movement of a sophoroseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:2001088
name: trisaccharide transport
namespace: biological_process
def: "The directed movement of a trisaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:2001089
name: maltotriose transport
namespace: biological_process
def: "The directed movement of a maltotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001090
name: maltotriulose transport
namespace: biological_process
def: "The directed movement of a maltotriuloseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001091
name: nigerotriose transport
namespace: biological_process
def: "The directed movement of a nigerotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001092
name: arabinotriose transport
namespace: biological_process
def: "The directed movement of an arabinotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001093
name: galactotriose transport
namespace: biological_process
def: "The directed movement of a galactotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001094
name: xylotriose transport
namespace: biological_process
def: "The directed movement of a xylotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001095
name: mannotriose transport
namespace: biological_process
def: "The directed movement of a mannotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001096
name: cellotriose transport
namespace: biological_process
def: "The directed movement of a cellotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001097
name: laminaritriose transport
namespace: biological_process
def: "The directed movement of a laminaritrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:2001098
name: tetrasaccharide transport
namespace: biological_process
def: "The directed movement of a tetrasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:2001099
name: maltotetraose transport
namespace: biological_process
def: "The directed movement of a maltotetraoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001098 ! tetrasaccharide transport

[Term]
id: GO:2001100
name: pentasaccharide transport
namespace: biological_process
def: "The directed movement of a pentasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:2001101
name: maltopentaose transport
namespace: biological_process
def: "The directed movement of a maltopentaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001100 ! pentasaccharide transport

[Term]
id: GO:2001102
name: hexasaccharide transport
namespace: biological_process
def: "The directed movement of a hexasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:2001103
name: maltohexaose transport
namespace: biological_process
def: "The directed movement of a maltohexaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001102 ! hexasaccharide transport

[Term]
id: GO:2001104
name: heptasaccharide transport
namespace: biological_process
def: "The directed movement of a heptasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:2001105
name: maltoheptaose transport
namespace: biological_process
def: "The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001104 ! heptasaccharide transport

[Term]
id: GO:2001106
name: regulation of Rho guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol]
synonym: "regulation of RhoGEF" EXACT [GOC:obol]
is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity

[Term]
id: GO:2001107
name: negative regulation of Rho guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol]
synonym: "negative regulation of RhoGEF" EXACT [GOC:obol]
is_a: GO:1905098 ! negative regulation of guanyl-nucleotide exchange factor activity

[Term]
id: GO:2001108
name: positive regulation of Rho guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol]
synonym: "positive regulation of RhoGEF" EXACT [GOC:obol]
is_a: GO:1905099 ! positive regulation of guanyl-nucleotide exchange factor activity

[Term]
id: GO:2001109
name: regulation of lens epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0097166 ! lens epithelial cell proliferation

[Term]
id: GO:2001110
name: negative regulation of lens epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2001109 ! regulation of lens epithelial cell proliferation
relationship: negatively_regulates GO:0097166 ! lens epithelial cell proliferation

[Term]
id: GO:2001111
name: positive regulation of lens epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:2001109 ! regulation of lens epithelial cell proliferation
relationship: positively_regulates GO:0097166 ! lens epithelial cell proliferation

[Term]
id: GO:2001112
name: regulation of cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol]
synonym: "regulation of cellular response to HGF stimulus" EXACT [GOC:obol]
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus

[Term]
id: GO:2001113
name: negative regulation of cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol]
synonym: "negative regulation of cellular response to HGF stimulus" EXACT [GOC:obol]
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus
relationship: negatively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus

[Term]
id: GO:2001114
name: positive regulation of cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol]
synonym: "positive regulation of cellular response to HGF stimulus" EXACT [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus
relationship: positively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus

[Term]
id: GO:2001115
name: methanopterin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a methanopterin." [GOC:mengo_curators]
synonym: "methanopterin metabolism" EXACT [GOC:obol]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:2001116
name: methanopterin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methanopterin." [GOC:mengo_curators]
synonym: "methanopterin biosynthesis" EXACT [GOC:obol]
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:2001115 ! methanopterin-containing compound metabolic process

[Term]
id: GO:2001117
name: tetrahydromethanopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a tetrahydromethanopterin." [GOC:mengo_curators]
synonym: "tetrahydromethanopterin metabolism" EXACT [GOC:obol]
is_a: GO:2001115 ! methanopterin-containing compound metabolic process

[Term]
id: GO:2001118
name: tetrahydromethanopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin." [GOC:mengo_curators]
synonym: "tetrahydromethanopterin biosynthesis" EXACT [GOC:obol]
is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process
is_a: GO:2001117 ! tetrahydromethanopterin metabolic process

[Term]
id: GO:2001119
name: methanofuran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a methanofuran." [GOC:mengo_curators]
synonym: "methanofuran metabolism" EXACT [GOC:obol]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:2001120
name: methanofuran biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methanofuran." [GOC:mengo_curators]
synonym: "methanofuran biosynthesis" EXACT [GOC:obol]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:2001119 ! methanofuran metabolic process

[Term]
id: GO:2001121
name: coenzyme gamma-F420-2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2." [GOC:mengo_curators]
synonym: "coenzyme gamma-F420-2 biosynthesis" EXACT [GOC:obol]
is_a: GO:0052649 ! coenzyme gamma-F420-2 metabolic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:2001122
name: maltoheptaose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a maltoheptaose." [GOC:mengo_curators]
synonym: "maltoheptaose metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:2001123
name: maltoheptaose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a maltoheptaose." [GOC:mengo_curators]
synonym: "maltoheptaose catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2001122 ! maltoheptaose metabolic process

[Term]
id: GO:2001124
name: regulation of translational frameshifting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational frameshifting." [GOC:obol]
is_a: GO:0006448 ! regulation of translational elongation
relationship: regulates GO:0006452 ! translational frameshifting

[Term]
id: GO:2001125
name: negative regulation of translational frameshifting
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting." [GOC:obol]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:2001124 ! regulation of translational frameshifting
relationship: negatively_regulates GO:0006452 ! translational frameshifting

[Term]
id: GO:2001126
name: positive regulation of translational frameshifting
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational frameshifting." [GOC:obol]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:2001124 ! regulation of translational frameshifting
relationship: positively_regulates GO:0006452 ! translational frameshifting

[Term]
id: GO:2001127
name: methane biosynthetic process from formic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a formic acid." [GOC:mengo_curators]
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:2001128
name: methane biosynthetic process from methylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a methylamine." [GOC:mengo_curators]
is_a: GO:0015948 ! methanogenesis
is_a: GO:0030416 ! methylamine metabolic process

[Term]
id: GO:2001129
name: methane biosynthetic process from dimethylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethylamine." [GOC:mengo_curators]
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:2001130
name: methane biosynthetic process from trimethylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a trimethylamine." [GOC:mengo_curators]
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:2001131
name: methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethyl sulfide." [GOC:mengo_curators]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:2001132
name: methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid." [GOC:mengo_curators]
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:2001133
name: methane biosynthetic process from methanethiol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a methanethiol." [GOC:mengo_curators]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:2001134
name: methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide." [GOC:mengo_curators]
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:2001135
name: regulation of endocytic recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytic recycling." [GOC:obol]
synonym: "regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0032456 ! endocytic recycling

[Term]
id: GO:2001136
name: negative regulation of endocytic recycling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling." [GOC:obol]
synonym: "negative regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:2001135 ! regulation of endocytic recycling
relationship: negatively_regulates GO:0032456 ! endocytic recycling

[Term]
id: GO:2001137
name: positive regulation of endocytic recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocytic recycling." [GOC:obol]
synonym: "positive regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:2001135 ! regulation of endocytic recycling
relationship: positively_regulates GO:0032456 ! endocytic recycling

[Term]
id: GO:2001138
name: regulation of phospholipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid transport." [GOC:obol]
is_a: GO:0032368 ! regulation of lipid transport
relationship: regulates GO:0015914 ! phospholipid transport

[Term]
id: GO:2001139
name: negative regulation of phospholipid transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid transport." [GOC:obol]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:2001138 ! regulation of phospholipid transport
relationship: negatively_regulates GO:0015914 ! phospholipid transport

[Term]
id: GO:2001140
name: positive regulation of phospholipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid transport." [GOC:obol]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:2001138 ! regulation of phospholipid transport
relationship: positively_regulates GO:0015914 ! phospholipid transport

[Term]
id: GO:2001141
name: regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
synonym: "regulation of RNA anabolism" EXACT [GOC:obol]
synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol]
synonym: "regulation of RNA formation" EXACT [GOC:obol]
synonym: "regulation of RNA synthesis" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0032774 ! RNA biosynthetic process

[Term]
id: GO:2001142
name: nicotinate transport
namespace: biological_process
def: "The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:2001143
name: N-methylnicotinate transport
namespace: biological_process
def: "The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015697 ! quaternary ammonium group transport

[Term]
id: GO:2001144
name: regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:2001145
name: negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
is_a: GO:0010923 ! negative regulation of phosphatase activity
is_a: GO:2001144 ! regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

[Term]
id: GO:2001146
name: obsolete positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:2001147
name: camalexin binding
namespace: molecular_function
def: "Binding to camalexin." [GOC:obol]
synonym: "3-(1,3-thiazol-2-yl)-1H-indole binding" EXACT [GOC:obol]
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:2001148
name: regulation of dipeptide transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol]
synonym: "regulation of dipeptide membrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0090089 ! regulation of dipeptide transport
relationship: regulates GO:0035442 ! dipeptide transmembrane transport

[Term]
id: GO:2001149
name: negative regulation of dipeptide transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol]
synonym: "negative regulation of dipeptide membrane transport" EXACT []
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:2000879 ! negative regulation of dipeptide transport
is_a: GO:2001148 ! regulation of dipeptide transmembrane transport
relationship: negatively_regulates GO:0035442 ! dipeptide transmembrane transport

[Term]
id: GO:2001150
name: positive regulation of dipeptide transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol]
synonym: "positive regulation of dipeptide membrane transport" EXACT []
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:2000880 ! positive regulation of dipeptide transport
is_a: GO:2001148 ! regulation of dipeptide transmembrane transport
relationship: positively_regulates GO:0035442 ! dipeptide transmembrane transport

[Term]
id: GO:2001151
name: regulation of renal water transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal water transport." [GOC:obol]
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051049 ! regulation of transport
is_a: GO:0098801 ! regulation of renal system process
relationship: regulates GO:0003097 ! renal water transport

[Term]
id: GO:2001152
name: negative regulation of renal water transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." [GOC:obol]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2001151 ! regulation of renal water transport
relationship: negatively_regulates GO:0003097 ! renal water transport

[Term]
id: GO:2001153
name: positive regulation of renal water transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal water transport." [GOC:obol]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2001151 ! regulation of renal water transport
relationship: positively_regulates GO:0003097 ! renal water transport

[Term]
id: GO:2001154
name: regulation of glycolytic fermentation to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol]
synonym: "regulation of ethanol fermentation" EXACT [GOC:obol]
synonym: "regulation of glucose fermentation to ethanol" EXACT [GOC:obol]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0043465 ! regulation of fermentation
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0019655 ! glycolytic fermentation to ethanol

[Term]
id: GO:2001155
name: negative regulation of glycolytic fermentation to ethanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol]
synonym: "negative regulation of ethanol fermentation" EXACT [GOC:obol]
synonym: "negative regulation of glucose fermentation to ethanol" EXACT [GOC:obol]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901003 ! negative regulation of fermentation
is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol
relationship: negatively_regulates GO:0019655 ! glycolytic fermentation to ethanol

[Term]
id: GO:2001156
name: regulation of proline catabolic process to glutamate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol]
synonym: "regulation of proline breakdown to glutamate" EXACT [GOC:obol]
synonym: "regulation of proline degradation to glutamate" EXACT [GOC:obol]
synonym: "regulation of proline oxidation" RELATED [GOC:obol]
is_a: GO:0033241 ! regulation of amine catabolic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
is_a: GO:2000214 ! regulation of proline metabolic process
relationship: regulates GO:0010133 ! proline catabolic process to glutamate

[Term]
id: GO:2001157
name: negative regulation of proline catabolic process to glutamate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol]
synonym: "negative regulation of proline breakdown to glutamate" EXACT [GOC:obol]
synonym: "negative regulation of proline degradation to glutamate" EXACT [GOC:obol]
synonym: "negative regulation of proline oxidation" RELATED [GOC:obol]
is_a: GO:0033242 ! negative regulation of amine catabolic process
is_a: GO:2000212 ! negative regulation of glutamate metabolic process
is_a: GO:2000215 ! negative regulation of proline metabolic process
is_a: GO:2001156 ! regulation of proline catabolic process to glutamate
relationship: negatively_regulates GO:0010133 ! proline catabolic process to glutamate

[Term]
id: GO:2001158
name: positive regulation of proline catabolic process to glutamate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol]
synonym: "positive regulation of proline breakdown to glutamate" EXACT [GOC:obol]
synonym: "positive regulation of proline degradation to glutamate" EXACT [GOC:obol]
synonym: "positive regulation of proline oxidation" RELATED [GOC:obol]
is_a: GO:0033243 ! positive regulation of amine catabolic process
is_a: GO:2000213 ! positive regulation of glutamate metabolic process
is_a: GO:2000216 ! positive regulation of proline metabolic process
is_a: GO:2001156 ! regulation of proline catabolic process to glutamate
relationship: positively_regulates GO:0010133 ! proline catabolic process to glutamate

[Term]
id: GO:2001159
name: regulation of protein localization by the Cvt pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway." [GOC:obol]
synonym: "regulation of cytoplasm to vacuole targeting" EXACT [GOC:obol]
synonym: "regulation of cytoplasm-to-vacuole targeting" EXACT [GOC:obol]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903533 ! regulation of protein targeting
relationship: regulates GO:0032258 ! cytoplasm to vacuole targeting by the Cvt pathway

[Term]
id: GO:2001160
name: obsolete regulation of histone H3-K79 methylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of histone H3 K79 methylation" EXACT [GOC:obol]
synonym: "regulation of histone H3K79me" EXACT [GOC:obol]
synonym: "regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0140673
consider: GO:0140861

[Term]
id: GO:2001161
name: obsolete negative regulation of histone H3-K79 methylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of histone H3 K79 methylation" EXACT [GOC:obol]
synonym: "negative regulation of histone H3K79me" EXACT [GOC:obol]
synonym: "negative regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:2001162
name: obsolete positive regulation of histone H3-K79 methylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of histone H3 K79 methylation" EXACT [GOC:obol]
synonym: "positive regulation of histone H3K79me" EXACT [GOC:obol]
synonym: "positive regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol]
is_obsolete: true
consider: GO:0140673
consider: GO:0140861

[Term]
id: GO:2001163
name: obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:2001164
name: obsolete negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594]
comment: This term was obsoleted because it represents both a molecular function and a biological process.
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:2001165
name: obsolete positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594]
comment: This term has been obsoleted because it represents both a molecular function and a biological process.
is_obsolete: true
consider: GO:0006357

[Term]
id: GO:2001166
name: obsolete regulation of histone H2B ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:2001167
name: obsolete negative regulation of histone H2B ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:2001168
name: obsolete positive regulation of histone H2B ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true

[Term]
id: GO:2001169
name: regulation of ATP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]
synonym: "regulation of ATP anabolism" EXACT [GOC:obol]
synonym: "regulation of ATP biosynthesis" EXACT [GOC:obol]
synonym: "regulation of ATP formation" EXACT [GOC:obol]
synonym: "regulation of ATP regeneration" RELATED [GOC:obol]
synonym: "regulation of ATP synthesis" EXACT [GOC:obol]
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
is_a: GO:1903578 ! regulation of ATP metabolic process
relationship: regulates GO:0006754 ! ATP biosynthetic process

[Term]
id: GO:2001170
name: negative regulation of ATP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]
synonym: "negative regulation of ATP anabolism" EXACT [GOC:obol]
synonym: "negative regulation of ATP biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of ATP formation" EXACT [GOC:obol]
synonym: "negative regulation of ATP regeneration" RELATED [GOC:obol]
synonym: "negative regulation of ATP synthesis" EXACT [GOC:obol]
is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process
is_a: GO:1903579 ! negative regulation of ATP metabolic process
is_a: GO:2001169 ! regulation of ATP biosynthetic process
relationship: negatively_regulates GO:0006754 ! ATP biosynthetic process

[Term]
id: GO:2001171
name: positive regulation of ATP biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]
synonym: "positive regulation of ATP anabolism" EXACT [GOC:obol]
synonym: "positive regulation of ATP biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of ATP formation" EXACT [GOC:obol]
synonym: "positive regulation of ATP regeneration" RELATED [GOC:obol]
synonym: "positive regulation of ATP synthesis" EXACT [GOC:obol]
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
is_a: GO:1903580 ! positive regulation of ATP metabolic process
is_a: GO:2001169 ! regulation of ATP biosynthetic process
relationship: positively_regulates GO:0006754 ! ATP biosynthetic process

[Term]
id: GO:2001172
name: positive regulation of glycolytic fermentation to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol]
synonym: "positive regulation of ethanol fermentation" EXACT [GOC:obol]
synonym: "positive regulation of glucose fermentation to ethanol" EXACT [GOC:obol]
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol
relationship: positively_regulates GO:0019655 ! glycolytic fermentation to ethanol

[Term]
id: GO:2001173
name: obsolete regulation of histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814]
comment: This term was obsoleted because it represents a molecular function.
synonym: "regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol]
synonym: "regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol]
synonym: "regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:2001174
name: obsolete negative regulation of histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814]
comment: This term was obsoleted because it represents a molecular function.
synonym: "negative regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol]
synonym: "negative regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol]
synonym: "negative regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:2001175
name: obsolete positive regulation of histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814]
comment: This term was obsoleted because it represents a molecular function.
synonym: "positive regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol]
synonym: "positive regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol]
synonym: "positive regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol]
is_obsolete: true

[Term]
id: GO:2001176
name: regulation of mediator complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mediator complex assembly." [GOC:obol]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
relationship: regulates GO:0036034 ! mediator complex assembly

[Term]
id: GO:2001177
name: negative regulation of mediator complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mediator complex assembly." [GOC:obol]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:2001176 ! regulation of mediator complex assembly
relationship: negatively_regulates GO:0036034 ! mediator complex assembly

[Term]
id: GO:2001178
name: positive regulation of mediator complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mediator complex assembly." [GOC:obol]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:2001176 ! regulation of mediator complex assembly
relationship: positively_regulates GO:0036034 ! mediator complex assembly

[Term]
id: GO:2001185
name: regulation of CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation

[Term]
id: GO:2001186
name: negative regulation of CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
relationship: negatively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation

[Term]
id: GO:2001187
name: positive regulation of CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
relationship: positively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation

[Term]
id: GO:2001188
name: regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol]
synonym: "regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0050776 ! regulation of immune response
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

[Term]
id: GO:2001189
name: negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol]
synonym: "negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:0050868 ! negative regulation of T cell activation
is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
relationship: negatively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

[Term]
id: GO:2001190
name: positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol]
synonym: "positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
relationship: positively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

[Term]
id: GO:2001191
name: regulation of gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol]
synonym: "regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol]
synonym: "regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol]
synonym: "regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol]
synonym: "regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002290 ! gamma-delta T cell activation involved in immune response

[Term]
id: GO:2001192
name: negative regulation of gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol]
synonym: "negative regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol]
synonym: "negative regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol]
synonym: "negative regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol]
synonym: "negative regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response
relationship: negatively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response

[Term]
id: GO:2001193
name: positive regulation of gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol]
synonym: "positive regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol]
synonym: "positive regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol]
synonym: "positive regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol]
synonym: "positive regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response
relationship: positively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response

[Term]
id: GO:2001194
name: regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol]
synonym: "regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol]
synonym: "regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol]
is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid
relationship: regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine

[Term]
id: GO:2001195
name: negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol]
synonym: "negative regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol]
synonym: "negative regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol]
is_a: GO:1902987 ! negative regulation of lysine biosynthetic process via aminoadipic acid
is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
relationship: negatively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine

[Term]
id: GO:2001196
name: positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol]
synonym: "positive regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol]
synonym: "positive regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol]
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
relationship: positively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine

[Term]
id: GO:2001197
name: basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any basement membrane assembly that is involved in embryonic body morphogenesis." [GOC:obol]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0070831 ! basement membrane assembly
relationship: part_of GO:0010172 ! embryonic body morphogenesis

[Term]
id: GO:2001198
name: regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902105 ! regulation of leukocyte differentiation
relationship: regulates GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:2001199
name: negative regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
is_a: GO:2001198 ! regulation of dendritic cell differentiation
relationship: negatively_regulates GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:2001200
name: positive regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
is_a: GO:2001198 ! regulation of dendritic cell differentiation
relationship: positively_regulates GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:2001204
name: regulation of osteoclast development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol]
synonym: "regulation of osteoclast cell development" EXACT [GOC:obol]
is_a: GO:1903706 ! regulation of hemopoiesis
relationship: regulates GO:0036035 ! osteoclast development

[Term]
id: GO:2001205
name: negative regulation of osteoclast development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol]
synonym: "negative regulation of osteoclast cell development" EXACT [GOC:obol]
is_a: GO:0045671 ! negative regulation of osteoclast differentiation
is_a: GO:2001204 ! regulation of osteoclast development
relationship: negatively_regulates GO:0036035 ! osteoclast development

[Term]
id: GO:2001206
name: positive regulation of osteoclast development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol]
synonym: "positive regulation of osteoclast cell development" EXACT [GOC:obol]
is_a: GO:0045672 ! positive regulation of osteoclast differentiation
is_a: GO:2001204 ! regulation of osteoclast development
relationship: positively_regulates GO:0036035 ! osteoclast development

[Term]
id: GO:2001207
name: regulation of transcription elongation by RNA polymerase I
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458]
synonym: "regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol]
synonym: "regulation of transcription elongation from RNA polymerase I promoter" EXACT []
is_a: GO:0032784 ! regulation of DNA-templated transcription elongation
relationship: regulates GO:0006362 ! transcription elongation by RNA polymerase I

[Term]
id: GO:2001208
name: negative regulation of transcription elongation by RNA polymerase I
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I." [PMID:20299458]
synonym: "negative regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol]
synonym: "negative regulation of transcription elongation from RNA polymerase I promoter" EXACT []
is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I
is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation
is_a: GO:2001207 ! regulation of transcription elongation by RNA polymerase I
relationship: negatively_regulates GO:0006362 ! transcription elongation by RNA polymerase I

[Term]
id: GO:2001209
name: positive regulation of transcription elongation by RNA polymerase I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458]
synonym: "positive regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol]
synonym: "positive regulation of transcription elongation from RNA polymerase I promoter" EXACT []
is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation
is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I
is_a: GO:2001207 ! regulation of transcription elongation by RNA polymerase I
relationship: positively_regulates GO:0006362 ! transcription elongation by RNA polymerase I

[Term]
id: GO:2001210
name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al]
synonym: "regulation of Ac-MVA pathway" EXACT [GOC:obol]
synonym: "regulation of acetate-mevalonate pathway" EXACT [GOC:obol]
synonym: "regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol]
synonym: "regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol]
synonym: "regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol]
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway

[Term]
id: GO:2001211
name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al]
synonym: "negative regulation of Ac-MVA pathway" EXACT [GOC:obol]
synonym: "negative regulation of acetate-mevalonate pathway" EXACT [GOC:obol]
synonym: "negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol]
synonym: "negative regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol]
synonym: "negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol]
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
relationship: negatively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway

[Term]
id: GO:2001212
name: regulation of vasculogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0001570 ! vasculogenesis

[Term]
id: GO:2001213
name: negative regulation of vasculogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2001212 ! regulation of vasculogenesis
relationship: negatively_regulates GO:0001570 ! vasculogenesis

[Term]
id: GO:2001214
name: positive regulation of vasculogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2001212 ! regulation of vasculogenesis
relationship: positively_regulates GO:0001570 ! vasculogenesis

[Term]
id: GO:2001215
name: obsolete regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al]
comment: This term has been obsoleted because it represents a molecular function.
synonym: "regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol]
synonym: "regulation of HMG-CoA reductase activity" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0030234
consider: GO:0106107

[Term]
id: GO:2001216
name: obsolete negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al]
comment: This term has been obsoleted because it represents a molecular function.
synonym: "negative regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol]
synonym: "negative regulation of HMG-CoA reductase activity" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0004857
consider: GO:0106108

[Term]
id: GO:2001217
name: obsolete regulation of S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "regulation of S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0044770

[Term]
id: GO:2001218
name: obsolete negative regulation of S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "negative regulation of S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:2001219
name: obsolete positive regulation of S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "positive regulation of S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:2001220
name: obsolete negative regulation of G2 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "negative regulation of G2 phase of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:2001221
name: obsolete positive regulation of G2 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "positive regulation of G2 phase of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:2001222
name: regulation of neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "regulation of neuron guidance" RELATED [GOC:obol]
synonym: "regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0001764 ! neuron migration

[Term]
id: GO:2001223
name: negative regulation of neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "negative regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "negative regulation of neuron guidance" RELATED [GOC:obol]
synonym: "negative regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:2001222 ! regulation of neuron migration
relationship: negatively_regulates GO:0001764 ! neuron migration

[Term]
id: GO:2001224
name: positive regulation of neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "positive regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "positive regulation of neuron guidance" RELATED [GOC:obol]
synonym: "positive regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:2001222 ! regulation of neuron migration
relationship: positively_regulates GO:0001764 ! neuron migration

[Term]
id: GO:2001225
name: regulation of chloride transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chloride transport." [GOC:dph]
is_a: GO:0044070 ! regulation of monoatomic anion transport
relationship: regulates GO:0006821 ! chloride transport

[Term]
id: GO:2001226
name: negative regulation of chloride transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport." [GOC:dph]
is_a: GO:1903792 ! negative regulation of monoatomic anion transport
is_a: GO:2001225 ! regulation of chloride transport
relationship: negatively_regulates GO:0006821 ! chloride transport

[Term]
id: GO:2001227
name: quercitrin binding
namespace: molecular_function
def: "Binding to quercitrin." [GOC:obol]
is_a: GO:0043168 ! anion binding
is_a: GO:0097243 ! flavonoid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:2001228
name: regulation of response to gamma radiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to gamma radiation." [GOC:obol]
synonym: "regulation of response to gamma ray" RELATED [GOC:obol]
synonym: "regulation of response to gamma-ray photon" RELATED [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0010332 ! response to gamma radiation

[Term]
id: GO:2001229
name: negative regulation of response to gamma radiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol]
synonym: "negative regulation of response to gamma ray" RELATED [GOC:obol]
synonym: "negative regulation of response to gamma-ray photon" RELATED [GOC:obol]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2001228 ! regulation of response to gamma radiation
relationship: negatively_regulates GO:0010332 ! response to gamma radiation

[Term]
id: GO:2001230
name: positive regulation of response to gamma radiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to gamma radiation." [GOC:obol]
synonym: "positive regulation of response to gamma ray" RELATED [GOC:obol]
synonym: "positive regulation of response to gamma-ray photon" RELATED [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2001228 ! regulation of response to gamma radiation
relationship: positively_regulates GO:0010332 ! response to gamma radiation

[Term]
id: GO:2001231
name: regulation of protein localization to prospore membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to prospore membrane." [GOC:mah]
synonym: "regulation of protein localisation to prospore membrane" EXACT []
synonym: "regulation of protein targeting to ascospore-type prospore membrane" RELATED [GOC:obol]
synonym: "regulation of protein targeting to forespore membrane" RELATED [GOC:obol]
synonym: "regulation of protein targeting to FSM" RELATED [GOC:obol]
synonym: "regulation of protein targeting to prospore membrane" RELATED []
synonym: "regulation of protein-prospore membrane targeting" RELATED [GOC:obol]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
relationship: regulates GO:1902657 ! protein localization to prospore membrane

[Term]
id: GO:2001232
name: positive regulation of protein localization to prospore membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to prospore membrane." [GOC:mah]
synonym: "positive regulation of protein localisation to prospore membrane" EXACT []
synonym: "positive regulation of protein targeting to ascospore-type prospore membrane" RELATED [GOC:obol]
synonym: "positive regulation of protein targeting to forespore membrane" RELATED [GOC:obol]
synonym: "positive regulation of protein targeting to FSM" RELATED [GOC:obol]
synonym: "positive regulation of protein targeting to prospore membrane" RELATED []
synonym: "positive regulation of protein-prospore membrane targeting" RELATED [GOC:obol]
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
is_a: GO:2001231 ! regulation of protein localization to prospore membrane
relationship: positively_regulates GO:1902657 ! protein localization to prospore membrane

[Term]
id: GO:2001233
name: regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0042981 ! regulation of apoptotic process
relationship: regulates GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:2001234
name: negative regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
relationship: negatively_regulates GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:2001235
name: positive regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
relationship: positively_regulates GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:2001236
name: regulation of extrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of extrinsic apoptosis" NARROW []
synonym: "regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
relationship: regulates GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:2001237
name: negative regulation of extrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of extrinsic apoptosis" NARROW []
synonym: "negative regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:2001238
name: positive regulation of extrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of extrinsic apoptosis" NARROW []
synonym: "positive regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:2001239
name: regulation of extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]
synonym: "regulation of dependence receptor signaling pathway" RELATED [GOC:obol]
synonym: "regulation of extrinsic apoptosis in absence of ligand" NARROW []
synonym: "regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
relationship: regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand

[Term]
id: GO:2001240
name: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]
synonym: "negative regulation of dependence receptor signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of extrinsic apoptosis in absence of ligand" NARROW []
synonym: "negative regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:1901099 ! negative regulation of signal transduction in absence of ligand
is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand
relationship: negatively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand

[Term]
id: GO:2001241
name: positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]
synonym: "positive regulation of dependence receptor signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of extrinsic apoptosis in absence of ligand" NARROW []
synonym: "positive regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway
is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand
relationship: positively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand

[Term]
id: GO:2001242
name: regulation of intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of intrinsic apoptosis" NARROW []
synonym: "regulation of intrinsic apoptotic pathway" EXACT [GOC:obol]
synonym: "regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol]
is_a: GO:1902531 ! regulation of intracellular signal transduction
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
relationship: regulates GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:2001243
name: negative regulation of intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of intrinsic apoptosis" NARROW []
synonym: "negative regulation of intrinsic apoptotic pathway" EXACT [GOC:obol]
synonym: "negative regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol]
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:2001244
name: positive regulation of intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of intrinsic apoptosis" NARROW []
synonym: "positive regulation of intrinsic apoptotic pathway" EXACT [GOC:obol]
synonym: "positive regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol]
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:2001245
name: regulation of phosphatidylcholine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]
synonym: "regulation of phosphatidylcholine anabolism" EXACT [GOC:obol]
synonym: "regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol]
synonym: "regulation of phosphatidylcholine formation" EXACT [GOC:obol]
synonym: "regulation of phosphatidylcholine synthesis" EXACT [GOC:obol]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process
relationship: regulates GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:2001246
name: negative regulation of phosphatidylcholine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]
synonym: "negative regulation of phosphatidylcholine anabolism" EXACT [GOC:obol]
synonym: "negative regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of phosphatidylcholine formation" EXACT [GOC:obol]
synonym: "negative regulation of phosphatidylcholine synthesis" EXACT [GOC:obol]
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:0150174 ! negative regulation of phosphatidylcholine metabolic process
is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process
relationship: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:2001247
name: positive regulation of phosphatidylcholine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]
synonym: "positive regulation of phosphatidylcholine anabolism" EXACT [GOC:obol]
synonym: "positive regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of phosphatidylcholine formation" EXACT [GOC:obol]
synonym: "positive regulation of phosphatidylcholine synthesis" EXACT [GOC:obol]
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:0150173 ! positive regulation of phosphatidylcholine metabolic process
is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process
relationship: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:2001248
name: regulation of ammonia assimilation cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF]
synonym: "regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol]
synonym: "regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol]
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:2000211 ! regulation of glutamate metabolic process
relationship: regulates GO:0019676 ! ammonia assimilation cycle

[Term]
id: GO:2001249
name: negative regulation of ammonia assimilation cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF]
synonym: "negative regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol]
synonym: "negative regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol]
is_a: GO:0045847 ! negative regulation of nitrogen utilization
is_a: GO:2000212 ! negative regulation of glutamate metabolic process
is_a: GO:2001248 ! regulation of ammonia assimilation cycle
relationship: negatively_regulates GO:0019676 ! ammonia assimilation cycle

[Term]
id: GO:2001250
name: positive regulation of ammonia assimilation cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF]
synonym: "positive regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol]
synonym: "positive regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol]
is_a: GO:0045848 ! positive regulation of nitrogen utilization
is_a: GO:2000213 ! positive regulation of glutamate metabolic process
is_a: GO:2001248 ! regulation of ammonia assimilation cycle
relationship: positively_regulates GO:0019676 ! ammonia assimilation cycle

[Term]
id: GO:2001251
name: negative regulation of chromosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol]
synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol]
synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol]
synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol]
synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0033044 ! regulation of chromosome organization
relationship: negatively_regulates GO:0051276 ! chromosome organization

[Term]
id: GO:2001252
name: positive regulation of chromosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]
synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol]
synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol]
synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol]
synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0033044 ! regulation of chromosome organization
relationship: positively_regulates GO:0051276 ! chromosome organization

[Term]
id: GO:2001253
name: obsolete regulation of histone H3-K36 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0140673

[Term]
id: GO:2001254
name: obsolete negative regulation of histone H3-K36 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:2001255
name: obsolete positive regulation of histone H3-K36 trimethylation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059]
comment: This term was obsoleted because it represents a molecular function.
is_obsolete: true
consider: GO:0140673

[Term]
id: GO:2001256
name: regulation of store-operated calcium entry
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of store-operated calcium entry." [GOC:BHF]
synonym: "regulation of calcium ion import" RELATED [GOC:obol]
synonym: "regulation of capacitative calcium entry" EXACT [GOC:obol]
synonym: "regulation of SOCE" EXACT [GOC:obol]
synonym: "regulation of store-operated calcium import" EXACT [GOC:obol]
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: regulates GO:0002115 ! store-operated calcium entry

[Term]
id: GO:2001257
name: regulation of cation channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cation channel activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "regulation of cation diffusion facilitator activity" EXACT [GOC:obol]
synonym: "regulation of nonselective cation channel activity" EXACT [GOC:obol]
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport

[Term]
id: GO:2001258
name: negative regulation of cation channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of cation diffusion facilitator activity" EXACT [GOC:obol]
synonym: "negative regulation of nonselective cation channel activity" EXACT [GOC:obol]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:2001259
name: positive regulation of cation channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cation channel activity." [GOC:BHF]
subset: gocheck_obsoletion_candidate
synonym: "positive regulation of cation diffusion facilitator activity" EXACT [GOC:obol]
synonym: "positive regulation of nonselective cation channel activity" EXACT [GOC:obol]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:2001257 ! regulation of cation channel activity

[Term]
id: GO:2001260
name: regulation of semaphorin-plexin signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
synonym: "regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0071526 ! semaphorin-plexin signaling pathway

[Term]
id: GO:2001261
name: negative regulation of semaphorin-plexin signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
synonym: "negative regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway
relationship: negatively_regulates GO:0071526 ! semaphorin-plexin signaling pathway

[Term]
id: GO:2001262
name: positive regulation of semaphorin-plexin signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
synonym: "positive regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway
relationship: positively_regulates GO:0071526 ! semaphorin-plexin signaling pathway

[Term]
id: GO:2001263
name: regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:2001264
name: negative regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:2001263 ! regulation of C-C chemokine binding

[Term]
id: GO:2001265
name: positive regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:2001263 ! regulation of C-C chemokine binding

[Term]
id: GO:2001266
name: Roundabout signaling pathway involved in axon guidance
namespace: biological_process
def: "Any Roundabout signaling pathway that is involved in axon guidance." [GOC:bf, PMID:14527427, PMID:21820427]
synonym: "ROBO signaling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "ROBO signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "ROBO signaling pathway involved in axon guidance" EXACT [GOC:obol]
synonym: "ROBO signaling pathway involved in axon pathfinding" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon guidance" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon pathfinding" EXACT [GOC:obol]
synonym: "Roundabout signaling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "Roundabout signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "Roundabout signaling pathway involved in axon pathfinding" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon guidance" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon pathfinding" EXACT [GOC:obol]
is_a: GO:0035385 ! Roundabout signaling pathway
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:2001267
name: obsolete regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "regulation of initiator caspase activity" NARROW [GOC:obol]
is_obsolete: true
replaced_by: GO:2000116

[Term]
id: GO:2001268
name: obsolete negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of initiator caspase activity" NARROW [GOC:obol]
is_obsolete: true
replaced_by: GO:2000117

[Term]
id: GO:2001269
name: obsolete positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of initiator caspase activity" NARROW [GOC:obol]
is_obsolete: true
replaced_by: GO:2001056

[Term]
id: GO:2001270
name: obsolete regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "regulation of effector caspase activity" NARROW [GOC:obol]
is_obsolete: true
replaced_by: GO:2000116

[Term]
id: GO:2001271
name: obsolete negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "negative regulation of effector caspase activity" NARROW [GOC:obol]
is_obsolete: true
replaced_by: GO:2000117

[Term]
id: GO:2001272
name: obsolete positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]
comment: The reason for obsoletion is that this term represents a GO-CAM model.
synonym: "positive regulation of effector caspase activity" NARROW [GOC:obol]
is_obsolete: true
replaced_by: GO:2001056

[Term]
id: GO:2001273
name: obsolete regulation of glucose import in response to insulin stimulus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2001274
name: obsolete negative regulation of glucose import in response to insulin stimulus
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF]
synonym: "negative regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2001275
name: obsolete positive regulation of glucose import in response to insulin stimulus
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF]
comment: This term was obsoleted because it represents a GO-CAM model.
synonym: "positive regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol]
is_obsolete: true

[Term]
id: GO:2001276
name: regulation of L-leucine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-leucine biosynthetic process." [GOC:obol]
synonym: "regulation of L-leucine anabolism" EXACT [GOC:obol]
synonym: "regulation of L-leucine biosynthesis" EXACT [GOC:obol]
synonym: "regulation of L-leucine formation" EXACT [GOC:obol]
synonym: "regulation of L-leucine synthesis" EXACT [GOC:obol]
synonym: "regulation of leucine biosynthetic process" BROAD []
is_a: GO:0062012 ! regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
relationship: regulates GO:0009098 ! L-leucine biosynthetic process

[Term]
id: GO:2001277
name: negative regulation of L-leucine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-leucine biosynthetic process." [GOC:obol]
synonym: "negative regulation of L-leucine anabolism" EXACT [GOC:obol]
synonym: "negative regulation of L-leucine biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of L-leucine formation" EXACT [GOC:obol]
synonym: "negative regulation of L-leucine synthesis" EXACT [GOC:obol]
synonym: "negative regulation of leucine biosynthetic process" BROAD []
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process
is_a: GO:2001276 ! regulation of L-leucine biosynthetic process
relationship: negatively_regulates GO:0009098 ! L-leucine biosynthetic process

[Term]
id: GO:2001278
name: positive regulation of L-leucine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-leucine biosynthetic process." [GOC:obol]
synonym: "positive regulation of L-leucine anabolism" EXACT [GOC:obol]
synonym: "positive regulation of L-leucine biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of L-leucine formation" EXACT [GOC:obol]
synonym: "positive regulation of L-leucine synthesis" EXACT [GOC:obol]
synonym: "positive regulation of leucine biosynthetic process" BROAD []
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
is_a: GO:2001276 ! regulation of L-leucine biosynthetic process
relationship: positively_regulates GO:0009098 ! L-leucine biosynthetic process

[Term]
id: GO:2001279
name: regulation of unsaturated fatty acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636]
synonym: "regulation of fatty acid desaturation" RELATED [GOC:obol]
synonym: "regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol]
synonym: "regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol]
synonym: "regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of unsaturated fatty acid formation" EXACT [GOC:obol]
synonym: "regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
relationship: regulates GO:0006636 ! unsaturated fatty acid biosynthetic process

[Term]
id: GO:2001280
name: positive regulation of unsaturated fatty acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636]
synonym: "positive regulation of fatty acid desaturation" RELATED [GOC:obol]
synonym: "positive regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid formation" EXACT [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol]
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process
relationship: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process

[Term]
id: GO:2001281
name: regulation of muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle cell chemotaxis toward tendon cell." [GOC:sart]
synonym: "regulation of muscle cell attraction" RELATED [GOC:obol]
synonym: "regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell

[Term]
id: GO:2001282
name: negative regulation of muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells." [GOC:sart, PMID:19793885, PMID:20404543]
synonym: "arrest of muscle cell chemotaxis" NARROW [GOC:bf, GOC:sart, PMID:19793885]
synonym: "negative regulation of muscle cell attraction" RELATED [GOC:obol]
synonym: "negative regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:2001281 ! regulation of muscle cell chemotaxis toward tendon cell
relationship: negatively_regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell

[Term]
id: GO:2001283
name: Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus." [GOC:bf, GOC:obol, GOC:sart, PMID:19793885]
synonym: "ROBO signaling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "ROBO signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol]
synonym: "ROBO signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
synonym: "Roundabout signaling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "Roundabout signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
is_a: GO:0035385 ! Roundabout signaling pathway
relationship: part_of GO:0036061 ! muscle cell chemotaxis toward tendon cell

[Term]
id: GO:2001284
name: regulation of BMP secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of BMP secretion." [GOC:sart]
synonym: "regulation of BMP protein secretion" EXACT [GOC:obol]
synonym: "regulation of bone morphogenetic protein secretion" EXACT [GOC:obol]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0038055 ! BMP secretion

[Term]
id: GO:2001285
name: negative regulation of BMP secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion." [GOC:sart]
synonym: "negative regulation of BMP protein secretion" EXACT [GOC:obol]
synonym: "negative regulation of bone morphogenetic protein secretion" EXACT [GOC:obol]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:2001284 ! regulation of BMP secretion
relationship: negatively_regulates GO:0038055 ! BMP secretion

[Term]
id: GO:2001286
name: regulation of caveolin-mediated endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol]
synonym: "regulation of caveolae-dependent endocytosis" EXACT [GOC:obol]
synonym: "regulation of caveolae-mediated endocytosis" EXACT [GOC:obol]
synonym: "regulation of caveolin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0030100 ! regulation of endocytosis
relationship: regulates GO:0072584 ! caveolin-mediated endocytosis

[Term]
id: GO:2001287
name: negative regulation of caveolin-mediated endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol]
synonym: "negative regulation of caveolae-dependent endocytosis" EXACT [GOC:obol]
synonym: "negative regulation of caveolae-mediated endocytosis" EXACT [GOC:obol]
synonym: "negative regulation of caveolin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis
relationship: negatively_regulates GO:0072584 ! caveolin-mediated endocytosis

[Term]
id: GO:2001288
name: positive regulation of caveolin-mediated endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol]
synonym: "positive regulation of caveolae-dependent endocytosis" EXACT [GOC:obol]
synonym: "positive regulation of caveolae-mediated endocytosis" EXACT [GOC:obol]
synonym: "positive regulation of caveolin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis
relationship: positively_regulates GO:0072584 ! caveolin-mediated endocytosis

[Term]
id: GO:2001289
name: lipid X metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate." [GOC:obol]
synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol]
synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol]
synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol]
synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol]
synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolic process" EXACT [GOC:obol]
synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolism" EXACT [GOC:obol]
synonym: "lipid X metabolism" EXACT [GOC:obol]
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:2001290
name: hydroperoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a hydroperoxide." [GOC:rs, PMID:15917183, PMID:18084891]
synonym: "hydroperoxide metabolism" EXACT [GOC:obol]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:2001291
name: codeine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [GOC:yaf]
synonym: "codeine metabolism" EXACT [GOC:obol]
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:2001292
name: codeine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [GOC:yaf, PMID:8845855]
synonym: "codeine breakdown" EXACT [GOC:obol]
synonym: "codeine catabolism" EXACT [GOC:obol]
synonym: "codeine degradation" EXACT [GOC:obol]
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
is_a: GO:2001291 ! codeine metabolic process

[Term]
id: GO:2001293
name: malonyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A." [GOC:yaf, PMID:11902724, PMID:15726818, PMID:18981598]
synonym: "malonyl-CoA metabolism" EXACT [GOC:obol]
is_a: GO:0006637 ! acyl-CoA metabolic process

[Term]
id: GO:2001294
name: malonyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A." [GOC:yaf]
synonym: "malonyl-CoA breakdown" EXACT [GOC:obol]
synonym: "malonyl-CoA catabolism" EXACT [GOC:obol]
synonym: "malonyl-CoA degradation" EXACT [GOC:obol]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process
is_a: GO:2001293 ! malonyl-CoA metabolic process

[Term]
id: GO:2001295
name: malonyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A." [GOC:yaf, UniPathway:UPA00655]
synonym: "malonyl-CoA anabolism" EXACT [GOC:obol]
synonym: "malonyl-CoA biosynthesis" EXACT [GOC:obol]
synonym: "malonyl-CoA formation" EXACT [GOC:obol]
synonym: "malonyl-CoA synthesis" EXACT [GOC:obol]
is_a: GO:0071616 ! acyl-CoA biosynthetic process
is_a: GO:2001293 ! malonyl-CoA metabolic process

[Term]
id: GO:2001296
name: N(omega)-methyl-L-arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N(omega)-methyl-L-arginine." [GOC:rs, PMID:10510241]
synonym: "N(omega)-methyl-L-arginine metabolism" EXACT [GOC:obol]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:2001297
name: N(omega)-methyl-L-arginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine." [GOC:rs, PMID:10510241]
synonym: "N(omega)-methyl-L-arginine breakdown" EXACT [GOC:obol]
synonym: "N(omega)-methyl-L-arginine catabolism" EXACT [GOC:obol]
synonym: "N(omega)-methyl-L-arginine degradation" EXACT [GOC:obol]
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:2001296 ! N(omega)-methyl-L-arginine metabolic process

[Term]
id: GO:2001298
name: N(omega),N(omega)-dimethyl-L-arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [GOC:rs, PMID:10510241]
synonym: "N(omega),N(omega)-dimethyl-L-arginine metabolism" EXACT [GOC:obol]
is_a: GO:0006575 ! modified amino acid metabolic process
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process

[Term]
id: GO:2001299
name: N(omega),N(omega)-dimethyl-L-arginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [GOC:rs, PMID:10510241]
synonym: "N(omega),N(omega)-dimethyl-L-arginine breakdown" EXACT [GOC:obol]
synonym: "N(omega),N(omega)-dimethyl-L-arginine catabolism" EXACT [GOC:obol]
synonym: "N(omega),N(omega)-dimethyl-L-arginine degradation" EXACT [GOC:obol]
is_a: GO:0042219 ! modified amino acid catabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
is_a: GO:2001298 ! N(omega),N(omega)-dimethyl-L-arginine metabolic process

[Term]
id: GO:2001300
name: lipoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid." [GOC:mw]
synonym: "lipoxin metabolism" EXACT [GOC:obol]
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:2001301
name: lipoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid." [GOC:mw]
synonym: "lipoxin anabolism" EXACT [GOC:obol]
synonym: "lipoxin biosynthesis" EXACT [GOC:obol]
synonym: "lipoxin formation" EXACT [GOC:obol]
synonym: "lipoxin synthesis" EXACT [GOC:obol]
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
is_a: GO:2001300 ! lipoxin metabolic process

[Term]
id: GO:2001302
name: lipoxin A4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [GOC:mw]
synonym: "lipoxin A4 metabolism" EXACT [GOC:obol]
synonym: "LXA4 metabolic process" EXACT [GOC:obol]
synonym: "LXA4 metabolism" EXACT [GOC:obol]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
is_a: GO:2001300 ! lipoxin metabolic process

[Term]
id: GO:2001303
name: lipoxin A4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [GOC:mw]
synonym: "lipoxin A4 anabolism" EXACT [GOC:obol]
synonym: "lipoxin A4 biosynthesis" EXACT [GOC:obol]
synonym: "lipoxin A4 formation" EXACT [GOC:obol]
synonym: "lipoxin A4 synthesis" EXACT [GOC:obol]
synonym: "LXA4 anabolism" EXACT [GOC:obol]
synonym: "LXA4 biosynthesis" EXACT [GOC:obol]
synonym: "LXA4 biosynthetic process" EXACT [GOC:obol]
synonym: "LXA4 formation" EXACT [GOC:obol]
synonym: "LXA4 synthesis" EXACT [GOC:obol]
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:2001301 ! lipoxin biosynthetic process
is_a: GO:2001302 ! lipoxin A4 metabolic process

[Term]
id: GO:2001304
name: lipoxin B4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [GOC:mw]
synonym: "lipoxin B4 metabolism" EXACT [GOC:obol]
synonym: "LXB4 metabolic process" EXACT [GOC:obol]
synonym: "LXB4 metabolism" EXACT [GOC:obol]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
is_a: GO:2001300 ! lipoxin metabolic process

[Term]
id: GO:2001305
name: xanthone-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a xanthone-containing compound." [GOC:di]
synonym: "xanthone metabolism" NARROW [CHEBI:37647]
synonym: "xanthone-containing compound metabolism" EXACT [GOC:obol]
synonym: "xanthones metabolic process" EXACT [GOC:obol]
synonym: "xanthones metabolism" EXACT [GOC:obol]
is_a: GO:0042180 ! ketone metabolic process

[Term]
id: GO:2001306
name: lipoxin B4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [GOC:mw]
synonym: "lipoxin B4 anabolism" EXACT [GOC:obol]
synonym: "lipoxin B4 biosynthesis" EXACT [GOC:obol]
synonym: "lipoxin B4 formation" EXACT [GOC:obol]
synonym: "lipoxin B4 synthesis" EXACT [GOC:obol]
synonym: "LXB4 anabolism" EXACT [GOC:obol]
synonym: "LXB4 biosynthesis" EXACT [GOC:obol]
synonym: "LXB4 biosynthetic process" EXACT [GOC:obol]
synonym: "LXB4 formation" EXACT [GOC:obol]
synonym: "LXB4 synthesis" EXACT [GOC:obol]
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:2001301 ! lipoxin biosynthetic process
is_a: GO:2001304 ! lipoxin B4 metabolic process

[Term]
id: GO:2001307
name: xanthone-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a xanthone-containing compound." [GOC:di]
synonym: "xanthone biosynthesis" NARROW [CHEBI:37647]
synonym: "xanthone biosynthetic process" NARROW [CHEBI:37647]
synonym: "xanthone-containing compound anabolism" EXACT [GOC:obol]
synonym: "xanthone-containing compound biosynthesis" EXACT [GOC:obol]
synonym: "xanthone-containing compound formation" EXACT [GOC:obol]
synonym: "xanthone-containing compound synthesis" EXACT [GOC:obol]
synonym: "xanthones anabolism" EXACT [GOC:obol]
synonym: "xanthones biosynthesis" EXACT [GOC:obol]
synonym: "xanthones biosynthetic process" EXACT [GOC:obol]
synonym: "xanthones formation" EXACT [GOC:obol]
synonym: "xanthones synthesis" EXACT [GOC:obol]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:2001305 ! xanthone-containing compound metabolic process

[Term]
id: GO:2001308
name: gliotoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [PMID:16333108, PMID:17574915, PMID:18272357]
synonym: "gliotoxin metabolism" EXACT [GOC:obol]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:0043603 ! amide metabolic process

[Term]
id: GO:2001309
name: gliotoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357]
synonym: "gliotoxin breakdown" EXACT [GOC:obol]
synonym: "gliotoxin catabolism" EXACT [GOC:obol]
synonym: "gliotoxin degradation" EXACT [GOC:obol]
is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:2001308 ! gliotoxin metabolic process

[Term]
id: GO:2001310
name: gliotoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357, PMID:29966253]
synonym: "gliotoxin anabolism" EXACT [GOC:obol]
synonym: "gliotoxin biosynthesis" EXACT [GOC:obol]
synonym: "gliotoxin formation" EXACT [GOC:obol]
synonym: "gliotoxin synthesis" EXACT [GOC:obol]
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:2001308 ! gliotoxin metabolic process

[Term]
id: GO:2001311
name: lysobisphosphatidic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [GOC:mw]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolism" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate metabolic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate metabolism" EXACT [GOC:obol]
synonym: "LBPA metabolic process" EXACT [GOC:obol]
synonym: "LBPA metabolism" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid metabolism" EXACT [GOC:obol]
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0052646 ! alditol phosphate metabolic process

[Term]
id: GO:2001312
name: lysobisphosphatidic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [GOC:mw]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) anabolism" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthesis" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthetic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) formation" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) synthesis" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate anabolism" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthesis" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthetic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate formation" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate synthesis" EXACT [GOC:obol]
synonym: "LBPA anabolism" EXACT [GOC:obol]
synonym: "LBPA biosynthesis" EXACT [GOC:obol]
synonym: "LBPA biosynthetic process" EXACT [GOC:obol]
synonym: "LBPA formation" EXACT [GOC:obol]
synonym: "LBPA synthesis" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid anabolism" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid biosynthesis" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid formation" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid synthesis" EXACT [GOC:obol]
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:2001311 ! lysobisphosphatidic acid metabolic process

[Term]
id: GO:2001313
name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolism" EXACT [GOC:obol]
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:2001314
name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose breakdown" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolism" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose degradation" EXACT [GOC:obol]
is_a: GO:0009227 ! nucleotide-sugar catabolic process
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process

[Term]
id: GO:2001315
name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf, UniPathway:UPA00032]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose anabolism" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthesis" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose formation" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose synthesis" EXACT [GOC:obol]
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process

[Term]
id: GO:2001316
name: kojic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kojic acid." [GOC:di]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolic process" EXACT [GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolism" EXACT [GOC:obol]
synonym: "C6H6O4 metabolic process" RELATED [GOC:obol]
synonym: "C6H6O4 metabolism" RELATED [GOC:obol]
synonym: "kojic acid metabolism" EXACT [GOC:obol]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0120254 ! olefinic compound metabolic process

[Term]
id: GO:2001317
name: kojic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of kojic acid." [GOC:di]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:obol]
synonym: "C6H6O4 anabolism" RELATED [GOC:obol]
synonym: "C6H6O4 biosynthesis" RELATED [GOC:obol]
synonym: "C6H6O4 biosynthetic process" RELATED [GOC:obol]
synonym: "C6H6O4 formation" RELATED [GOC:obol]
synonym: "C6H6O4 synthesis" RELATED [GOC:obol]
synonym: "kojic acid anabolism" EXACT [GOC:obol]
synonym: "kojic acid biosynthesis" EXACT [GOC:obol]
synonym: "kojic acid formation" EXACT [GOC:obol]
synonym: "kojic acid synthesis" EXACT [GOC:obol]
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:2001316 ! kojic acid metabolic process

[Typedef]
id: has_ontology_root_term
name: has ontology root term
namespace: external
xref: IAO:0000700
is_metadata_tag: true
is_class_level: true

[Typedef]
id: negatively_regulates
name: negatively regulates
namespace: external
xref: RO:0002212
is_a: regulates ! regulates

[Typedef]
id: part_of
name: part of
namespace: external
xref: BFO:0000050
is_transitive: true

[Typedef]
id: positively_regulates
name: positively regulates
namespace: external
xref: RO:0002213
holds_over_chain: negatively_regulates negatively_regulates
is_a: regulates ! regulates

[Typedef]
id: regulates
name: regulates
namespace: external
xref: RO:0002211
is_transitive: true

[Typedef]
id: term_tracker_item
name: term tracker item
namespace: external
xref: IAO:0000233
is_metadata_tag: true
is_class_level: true